bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Laser Power on Achieving Ultra Low Stiffness in Resistive Strain Gauges Through on Laser Bonding Transfer‐Patterning of Multiwall Carbon Nanotubes (MWCNTs) onto Polydimethylsiloxane (PDMS) Film
Authors: Theogene Barayavuga , Cui Jianlei , Ren Xiaoying , Wei Fengqi , Wang Zhijun , Mei Xuesong 
Published: January 2024

AbstractThis study describes a novel stretchable and very sensitive strain gauge enabled by laser‐joining carbon nanotubes, resulting in unique architectures forming macroscopic web networks. The stiffness of the resistive strain sensor created by laser material patterning is reduced significantly, from 1.5824 to 0.142 kN m−1, corresponding to a change in laser power from 0 to 0.436 W. Many benefits of laser‐based bonding include precise and flexible local pattern production with minimal energy impact on the flexible substrate. Furthermore, the maximum Gauge factor of the sensor exhibits diverse trends with different strains, generating values of GF = 12.8 for strains less than 2.5% and GF = 165 for strains greater than 2.5% during extension‐retraction cycles. These disparities are the result of a dynamic fight between network degradation and regeneration.
Dynamic Orientation Control of Gold Nanorods in Polymer Brushes by Their Thickness Changes for Plasmon Switching
Authors: Sekizawa Yu , Hasegawa Yuka , Mitomo Hideyuki , Toyokawa Chisato , Yonamine Yusuke , Ijiro Kuniharu 
Published: January 2024

AbstractGold nanorods (AuNRs) have unique optical properties such as transverse and longitudinal localized surface plasmon resonance (T‐ and L‐LSPR). As the L‐LSPR absorption depends on the angle of the AuNRs to incident light and polarization, orientational control of AuNRs is a crucial issue. In spite of various techniques to control AuNR orientation, dynamic orientation tuning on a solid substrate remains challenging. Herein, dynamic changes are demonstrated in AuNR orientation in the anionic polymer (DNA) brushes via control of their thickness by salt concentration. AuNRs vertically align toward the substrates when their thickness exceeds the AuNR length. Once their thickness becomes shorter than the AuNR length, the attached AuNRs begin to tilt. The tilt reaches a maximum level close to horizontal when the thickness decreases to half that of the AuNR length. The dynamic control between the vertical (uniform) and tilted (random) orientation of the AuNRs showed not only absorption intensity changes in L‐LSPR but also the switching of side‐by‐side plasmon coupling. The polymer brush‐based system affords a novel platform for the stimuli‐responsive control of AuNR orientation on the substrates via changes in the thickness of polymer brushes for actively tunable plasmonic substrates.
Ligand and Substrate Effects on Regio‐ and Stereoselective Ru(II)‐Catalyzed Hydroacyloxylations to Vinylic Esters
Authors: Beasley Paul A. , McDonald Frank E. 
Published: January 2024

AbstractTwo Ru(II)‐catalytic systems were developed for anti‐Markovnikov regioselective hydroacyloxylations of terminal alkynes to vinylic esters. [Ru(NCCH3)6][(BF4)2] favors (E)‐vinylic ester products with arylacetylenes and select carboxylic acids, whereas a Ru scorpionate complex with two electron‐withdrawing ligands favors (Z)‐vinylic ester isomers.
A Mechanistic Insight on CuI‐Catalyzed Synthesis of Oxazolidinones through a Four‐Component Reaction
Authors: Pich Rosa , Mallet‐Ladeira Sonia , Lavedan Pierre , Lahitte Jean‐François , Remigy Jean‐Christophe , Pla Daniel , Gómez Montserrat 
Published: January 2024

AbstractIn this contribution, we describe a straightforward and efficient synthesis of oxazolidin‐2‐ones through a Cu(I)‐catalyzed four‐component coupling of amines, aldehydes, terminal alkynes, and CO2 via carboxylative cyclization of propargylamine intermediates. This strategy enables the selective synthesis of a variety of (Z)‐5‐alkylidene‐oxazolidin‐2‐ones substituted in positions 3, 4 and 5 of the heterocyclic core with a variety of functional groups, well‐tolerated in terms of scope. A mechanistic study was carried out monitoring the process in solution by different techniques (operando FTIR, multi‐nuclear NMR), with the aim of identifying the intermediates, both organic compounds and Cu(I) coordination complexes, which showed the plausible multi‐metallic nature of the catalytic intermediates (identified by X‐ray diffraction analyses on monocrystal).
Intrinsic Visible Plasmonic Properties of Colloidal PtIn2 Intermetallic Nanoparticles
Authors: Takekuma Haruka , Sato Ryota , Iida Kenji , Kawawaki Tokuhisa , Haruta Mitsutaka , Kurata Hiroki , Nobusada Katsuyuki , Teranishi Toshiharu 
Published: January 2024

AbstractMaterials that intrinsically exhibit localized surface plasmon resonance (LSPR) in the visible region have been predominantly researched on nanoparticles (NPs) composed of coinage metals, namely Au, Ag, and Cu. Here, as a coinage metal‐free intermetallic NPs, colloidal PtIn2 NPs with a C1 (CaF2‐type) crystal structure are synthesized by the liquid phase method, which evidently exhibit LSPR at wavelengths similar to face‐centered cubic (fcc)‐Au NPs. Computational simulations pointed out differences in the electronic structure and photo‐excited electron dynamics between C1‐PtIn2 and fcc‐Au NPs; reduces interband transition and stronger screening with smaller number of bound d‐electrons compare with fcc‐Au are unique origins of the visible plasmonic nature of C1‐PtIn2 NPs. These results strongly indicate that the intermetallic NPs are expected to address the development of alternative plasmonic materials by tuning their crystal structure and composition.
Traditional Electrochemical Zn2+ Intercalation/Extraction Mechanism Revisited: Unveiling Ion‐Exchange Mediated Irreversible Zn2+ Intercalation for the δ‐MnO2 Cathode in Aqueous Zn Ion Batteries
Authors: Cui Shuangshuang , Zhang Dan , Gan Yang 
Published: January 2024

AbstractRechargeable aqueous Zn/δ‐MnO2 batteries are extensively investigated owing to the low cost, safety and eco‐friendliness. However, the charge storage mechanism of δ‐MnO2 electrode is still in debate. In this paper, it is revealed that the Zn2+ intercalation in δ‐MnO2 electrode is an ion exchange process rather than the commonly‐conceived electrochemical process for the first time. Before the discharge/charge process, Zn2+ irreversibly intercalates into the structure of δ‐MnO2. The ion‐exchange mediated irreversible Zn2+ intercalation in δ‐MnO2 has no contribution to the capacity of δ‐MnO2 electrode during cycles. This study further reveals that the electrochemical H+ intercalation/extraction, the electrodissolution of δ‐MnO2 and the electrodissolution‐electrodeposition of vernadite dominate the charge storage process of δ‐MnO2 electrode. These findings shed new light on the fundamental understanding for the reaction mechanism of δ‐MnO2 electrode in aqueous batteries.
Harmonized Physical and Electrochemical Process Design for Densely Dispersed Cu Catalysts on Cu2O Absorbers for Efficient Photoelectrochemical CO2 Reduction Reaction
Authors: Kim Dong Su , Oh Shin Young , Lee Hak Hyeon , Cho Hyung Koun 
Published: January 2024

AbstractThe photoelectrochemical CO2 reduction reaction (photo‐CO2RR) is a promising technology to convert CO2 into high‐value‐added carbon‐based chemicals using a relatively low voltage, which can economically solve the problem of CO2 emissions. Nevertheless, unlike the conventional electrochemical CO2RR approach, photo‐CO2RR technology is in its initial development stage. Particularly, when sunlight is applied to photoelectrodes for photo‐CO2RR, severe photocorrosion is unavoidable, resulting in the deterioration of fundamental functions including device long‐term stability and conversion performance. This study proposes an innovative two‐step catalyst formation strategy to enable the efficient photo‐CO2RR with Cu catalysts prepared using intrinsic photocorrosion of the Cu2O absorption layer. This approach is based on the harmonized process design of the i) growth of physically generated Cu nanoparticles and ii) construction of improved photoelectrochemical Cu cluster catalysts. The vacuum‐evaporated Cu seeds are designed to induce an evenly dispersed electrical path on Cu2O, and the selectively concentrated electrical field from the Cu seeds provides preferential sites for metallic Cu catalysts in subsequent photoelectrochemical reduction. This harmonized combination process of Cu catalysts on Cu2O demonstrates a synergistic performance of −1.2 mA cm−2 at 0 VRHE with suppression of photocorrosion and produces ≈95% CO product gas (0.4 VRHE).
Recurrent missense variant identified in two unrelated families with MPZL2‐related hearing loss, expanding the variant spectrum associated with DFNB111
Authors: Lo Emma , Blair Justin , Yamamoto Nobuko , Diaz‐Miranda Maria Alejandra , Bedoukian Emma , Gray Christopher , Lawrence Audrey , Dedhia Kavita , Elden Lisa M. , Germiller John A. , Kazahaya Ken , Sobol Steven E. , Luo Minjie , Krantz Ian D. , Hartman Tiffiney R. 
Published: January 2024

AbstractMPZL2‐related hearing loss is a rare form of autosomal recessive hearing loss characterized by progressive, mild sloping to severe sensorineural hearing loss. Thirty‐five previously reported patients had biallelic truncating variants in MPZL2, with the exception of one patient with a missense variant of uncertain significance and a truncating variant. Here, we describe the clinical characteristics and genotypes of five patients from four families with confirmed MPZL2‐related hearing loss. A rare missense likely pathogenic variant [NM_005797.4(MPZL2):c.280C>T,p.(Arg94Trp)] located in exon 3 was confirmed to be in trans with a recurrent pathogenic truncating variant that segregated with hearing loss in three of the patients from two unrelated families. This is the first recurrent likely pathogenic missense variant identified in MPZL2. Apparently milder or later‐onset hearing loss associated with rare missense variants in MPZL2 indicates that some missense variants in this gene may cause a milder phenotype than that resulting from homozygous or compound heterozygous truncating variants. This study, along with the identification of truncating loss of function and missense MPZL2 variants in several diverse populations, suggests that MPZL2‐related hearing loss may be more common than previously appreciated and demonstrates the need for MPZL2 inclusion in hearing loss testing panels.
Omalizumab improves sleep and health status for patients with chronic rhinosinusitis with nasal polyps: An analysis of randomized clinical trials
Authors: Meltzer Eli O. , Mullol Joaquim , Ko Jinnie , Saenz Rebecca , Steinke John W. , Millette Lauren A. , Gevaert Philippe 
Published: January 2024

AbstractBackgroundPatients with chronic rhinosinusitis with nasal polyps (CRSwNP) have high incidence of sleep impairment. We evaluated the impact of omalizumab treatment on sleep characteristics and associated health status in patients with CRSwNP.MethodsPrespecified exploratory analysis assessed outcomes from patients included in the POLYP 1 and POLYP 2 phase 3 clinical trials and the open‐label extension. Sleep was assessed by the sleep domain of the Sino‐Nasal Outcome Test‐22 (SNOT‐22; MCID > 4 in patients with CRS) and the Medical Outcomes Study Sleep Scale (MOS‐Sleep). Health status was assessed by Healthy Days Core Module (HDCM) and sinonasal‐specific Patient Global Impression of Change (PGIC).ResultsOmalizumab improved sleep as assessed by the SNOT‐22 sleep domain. At week 24, adjusted mean (95%CI) SNOT‐22 sleep scores had reduced from baseline by −8.5 (–9.9 to –7.1) with omalizumab versus –2.7 (–4.1 to –1.3) with placebo. At week 52 (all patents on OMA), adjusted mean (95%CI) SNOT‐22 sleep scores had reduced from baseline by −10.1 (–11.4 to –8.7) with omalizumab. Improvements were observed in all eight items of the SNOT‐22 sleep domain: difficulty falling asleep, fatigue, frustration/restlessness/irritability, lack good night's sleep, reduced concentration, reduced productivity, wake up tired, and wake up at night. In addition, omalizumab improved six of eight sleep outcomes on the MOS‐Sleep scale. There were concurrent improvements in HDCM and PGIC.ConclusionOmalizumab improved sleep and self‐reported health status in patients with CRSwNP. This contributes to evidence that omalizumab provides value for patients beyond the reduction of sinonasal symptoms.
Surface‐Initiated Living Self‐Assembly of Polythiophene‐Based Conjugated Block Copolymer into Erect Micellar Brushes
Authors: Zhang Yuheng , Yang Lei , Sun Yan , Lin Geyu , Manners Ian , Qiu Huibin 
Published: January 2024

AbstractNanostructured conjugated polymers are of widespread interest due to their broad applications in organic optoelectronic devices, biomedical sensors and other fields. However, the alignment of conjugated nanostructures perpendicular to a surface remains a critical challenge. Herein, we report a facile method to directly self‐assemble a poly(3‐(2‐ethylhexyl)thiophene), P3EHT‐based block copolymer into densely aligned micellar brushes through surface‐initiated living crystallization‐driven self‐assembly. The presence of an ethyl pendant on the side group intrinsically moderates the crystallization rate of the polythiophene main chains, and hence favors the controlled living growth of long conjugated fibers and the subsequent fabrication of conjugated micellar brushes. The corona of the micellar brush can be further decorated with platinum nanoparticles, which enables the formation of erect nanoarrays with heights up to 2700 nm in the dried state. This also renders the micellar brush catalytically active toward hydrogen evolution reaction, which shows a low overpotential of 27 mV at 10 mA cm−2. Notably, the P3EHT‐based micellar brush can simultaneously grow with polyferrocenyldimethylsilane, PFS‐based micellar brush on the same surface without any significant interference between the two systems. Thus, these two micellar brushes can be patterned through site‐selective immobilization of two types of seeds followed by independent living self‐assembly.
An ER‐targeted, Viscosity‐sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway
Authors: Zeng Shuang , Wang Yang , Chen Chen , Kim Heejeong , Liu Xiaosheng , Jiang Maojun , Yu Yichu , Kafuti Yves S. , Chen Qixian , Wang Jingyun , Peng Xiaojun , Li Haidong , Yoon Juyoung 
Published: January 2024

AbstractThe concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend of modern medical advancement. Herein, we rationally designed the smart molecule ER‐ZS for endoplasmic reticulum (ER)‐targeted diagnosis and treatment in cell and animal models by combining hemicyanine dyes with ER‐targeted functional groups (p‐toluenesulfonamide). Owing to its ability to target the ER with a highly specific response to viscosity, ER‐ZS demonstrated substantial fluorescence turn‐on only after binding to the ER, independent of other physiological environments. In addition, ER‐ZS, being a small molecule, allows for the diagnosis of nonalcoholic fatty liver disease (NAFLD) via liver imaging based on high ER stress. Importantly, ER‐ZS is a type I photosensitizer, producing O2⋅− and ⋅OH under light irradiation. Thus, after irradiating for a certain period, the photodynamic therapy inflicted severe oxidative damage to the ER of tumor cells in hypoxic (2 % O2) conditions and activated the unique pyroptosis pathway, demonstrating excellent antitumor capacity in xenograft tumor models. Hence, the proposed strategy will likely shed new light on integrating molecular optics for NAFLD diagnosis and cancer therapy.
Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound
Authors: Hahmann Johannes , Ishaqat Aman , Lammers Twan , Herrmann Andreas 
Published: January 2024

AbstractUltrasound technology, synergistically harnessed with genetic engineering and chemistry concepts, has started to open the gateway to the remarkable realm of sonogenetics—a pioneering paradigm for remotely orchestrating cellular functions at the molecular level. This fusion not only enables precisely targeted imaging and therapeutic interventions, but also advances our comprehension of mechanobiology to unparalleled depths. Sonogenetic tools harness mechanical force within small tissue volumes while preserving the integrity of the surrounding physiological environment, reaching depths of up to tens of centimeters with high spatiotemporal precision. These capabilities circumvent the inherent physical limitations of alternative in vivo control methods such as optogenetics and magnetogenetics. In this review, we first discuss mechanosensitive ion channels, the most commonly utilized sonogenetic mediators, in both mammalian and non‐mammalian systems. Subsequently, we provide a comprehensive overview of state‐of‐the‐art sonogenetic approaches that leverage thermal or mechanical features of ultrasonic waves. Additionally, we explore strategies centered around the design of mechanochemically reactive macromolecular systems. Furthermore, we delve into the realm of ultrasound imaging of biomolecular function, encompassing the utilization of gas vesicles and acoustic reporter genes. Finally, we shed light on limitations and challenges of sonogenetics and present a perspective on the future of this promising technology.
Structural Distortion in the Wadsley‐Roth Niobium Molybdenum Oxide Phase Triggering Extraordinarily Stable Battery Performance
Authors: Wu Zhibin , Liang Gemeng , Kong Pang Wei , Zou Jinshuo , Zhang Wenchao , Chen Libao , Ji Xiaobo , Didier Christophe , Peterson Vanessa K. , Segre Carlo U. , Johannessen Bernt , Guo Zaiping 
Published: January 2024

AbstractWadsley‐Roth niobium oxide phases have attracted extensive research interest recently as promising battery anodes. We have synthesized the niobium‐molybdenum oxide shear phase (Nb, Mo)13O33 with superior electrochemical Li‐ion storage performance, including an ultralong cycling lifespan of at least 15000 cycles. During electrochemical cycling, a reversible single‐phase solid‐solution reaction with lithiated intermediate solid solutions is demonstrated using in situ X‐ray diffraction, with the valence and short‐range structural changes of the electrode probed by in situ Nb and Mo K‐edge X‐ray absorption spectroscopy. This work reveals that the superior stability of niobium molybdenum oxides is underpinned by changes in octahedral distortion during electrochemical reactions, and we report an in‐depth understanding of how this stabilizes the oxide structure during cycling with implications for future long‐life battery material design.
Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy
Authors: Liu Jianping , Zhang Ye , Yang Bowei , Jia Yingbo , Liu Rui‐Tian , Ding Lingwen , Shen Zheyu , Chen Xiaoyuan 
Published: January 2024

AbstractDendritic cell (DC) maturation and antigen presentation are key factors for successful vaccine‐based cancer immunotherapy. This study developed manganese‐based layered double hydroxide (Mn‐LDH) nanoparticles as a self‐adjuvanted vaccine carrier that not only promoted DC maturation through synergistically depleting endogenous glutathione (GSH) and activating STING signaling pathway, but also facilitated the delivery of model antigen ovalbumin (OVA) into lymph nodes and subsequent antigen presentation in DCs. Significant therapeutic‐prophylactic efficacy of the OVA‐loaded Mn‐LDH (OVA/Mn‐LDH) nanovaccine was determined by the tumor growth inhibition in the mice bearing B16‐OVA tumor. Our results showed that the OVA/Mn‐LDH nanoparticles could be a potent delivery system for cancer vaccine development without the need of adjuvant. Therefore, the combination of GSH exhaustion and STING pathway activation might be an advisable approach for promoting DC maturation and antigen presentation, finally improving cancer vaccine efficacy.
Disclosing Support‐Size‐Dependent Effect on Ambient Light‐Driven Photothermal CO2 Hydrogenation over Nickel/Titanium Dioxide
Authors: Li Qiang , Wang Chunqi , Wang Huiling , Chen Jin , Chen Jing , Jia Hongpeng 
Published: January 2024

AbstractThe size of support in heterogeneous catalysts can strongly affect the catalytic property but is rarely explored in light‐driven catalysis. Herein, we demonstrate the size of TiO2 support governs the selectivity in photothermal CO2 hydrogenation by tuning the metal‐support interactions (MSI). Small‐size TiO2 loading nickel (Ni/TiO2‐25) with enhanced MSI promotes photo‐induced electrons of TiO2 migrating to Ni nanoparticles, thus favoring the H2 cleavage and accelerating the CH4 formation (227.7 mmol g−1 h−1) under xenon light‐induced temperature of 360 °C. Conversely, Ni/TiO2‐100 with large TiO2 prefers yielding CO (94.2 mmol g−1 h−1) due to weak MSI, inefficient charge separation, and inadequate supply of activated hydrogen. Under ambient solar irradiation, Ni/TiO2‐25 achieves the optimized CH4 rate (63.0 mmol g−1 h−1) with selectivity of 99.8 %, while Ni/TiO2‐100 exhibits the CO selectivity of 90.0 % with rate of 30.0 mmol g−1 h−1. This work offers a novel approach to tailoring light‐driven catalytic properties by support size effect.
Therapeutic crisis intervention for families: an investigation of caregiver perceptions and experiences
Authors: George Sarah E. , Catchpole Chelsey , Skinner Rosemary , Barbaro Parma , Adey Nathan G. , Davies Simon 
Published: January 2024

AbstractThe Therapeutic Crisis Intervention for Families (TCI‐F) program aims to equip caregivers with the knowledge, skills, and confidence to deal with crisis situations involving their children. Despite the program's global dissemination, its influence on predictors of intervention uptake and caregiver experience is not understood. We therefore sought to investigate the changes in determinants of implementation behaviour from pre‐ to post‐TCI‐F. These include knowledge, confidence, and intention to implement new strategies, beliefs about consequences that implementation would be beneficial, beliefs that change was part of one's social role, and a sense of having sufficient resources and support. In addition, we sought to understand the experiences of program participation. Caregivers who participated in TCI‐F were invited to complete questionnaires about determinants of implementation behaviour before and after the program. They were also invited to complete a questionnaire about their experiences attending TCI‐F. One hundred fifty‐five participants completed questionnaires. Significant improvements were found in all determinants of implementation behaviour. Caregivers reported improved knowledge about program strategies, a belief that this was part of their role, confidence and capability in managing crises, beliefs that implementation will be beneficial, intentions to implement learned strategies, and a sense of being provided with sufficient resources and support. Additionally, participants reported high levels of satisfaction, hope for the future, improved coping, and overall well‐being following the program. Qualitative responses supported these findings and revealed that many participants expressed a wish that the program was available sooner and that additional maintenance support was available. Findings support the use of TCI‐F and indicate that this is a promising intervention for caregivers who are struggling to cope with the crisis behaviours of their children. As this is the first published empirical investigation of TCI‐F, avenues for further research are identified.