bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOSIALISASI PROGRAM PERENCANAAN PERSALINAN DAN PENCEGAHAN KOMPLIKASI (P4K) UNTUK MENINGKATKAN KEPEDULIAN TETANGGA DAN MASYARAKAT SEKITAR DALAM RANGKA MENDUKUNG GERAKAN SAYANG IBU
Authors: Limbong Theresia , Puspita Erika Wanda , Agustina Ayu , Malik Melyana 
Published: October 2023

Abstrak: Program P4K dengan pemasangan stiker, pendataan dan pemantauan ibu hamil dapat dilakuakn secara intensif oleh bidan bersama dengan suami, keluarga, kader, masyarakat, forum peduli KIA, serta pendeteksian dini kejadian komplikasi sehingga melalui pr0gram tersebut diharapkan dapat membantu dalam mempercepat penurunan angka kematian ibu melalui peningkatan peran aktif keluarga dan masyarakat dalam merencanakan persalinan yang aman dan persiapan menghadapi komplikasi dan tanda bahaya kebidanan bagi ibu sehingga melahirkan bayi yang sehat. Berdasarkan data SUPAS 2015, Angka Kematian Ibu telah menurun menjadi 305 / 100.000 kelahiran kesehatan 2015-2019. hidup (MCR, 2018). Sedangkan Angka Kematian Bayi terus mengalami penurunan merupakan 32/1000 kelahiran hidup pada tahun 2012 menjadi 22/1000 kelahiran hidup pada tahun 2015, sehingga hal ini perlu mendapatkan perhatian penuh dan kerja keras. Pengabdian kepada masyarakat ini bertujuan dengan melalui P4K masyarakat dapat mengembangkan norma sosial bahwa cara yang aman untuk menyelamatkan ibu hamil-bersalin-nifas dan bayi baru lahir ialah ke bidan memeriksakan kehamilan, bersalin, perawatan nifas, dan perawatan bayi baru lahir,atau ke tenaga kesehatan terampil di bidang kebidanan, sehingga kelak dapat mencapai dan mewujudkan visi Departemen Kesehatan merupakan “Masyarakat Mandiri untuk Hidup Sehat”. Pengabdian kepada masyarakat ini dilakukan dengan melakukan sosialisasi kepada masyarakat khususnya kader kesehatan. Luaran yang diharapkan dari pengabdian kepada masyarakat ini ialah diharapkan Masyarakat lebih cermat dalam memperhatikan pengembangan norma sosial cara yang aman untuk menyelamatkan ibu hamil-bersalin-nifas dan bayi baru lahir ialah ke bidan memeriksakan kehamilan, bersalin, perawatan nifas, dan perawatan bayi baru lahir.
MODEL EDUKASI MELALUI PANDUAN CHILD SAFETY PADA KELUARGA DI KOTA MAKASSAR
Authors: Muhasida Muhasida , Angriani Sri , Nur Muhammad , Nasrullah Nasrullah 
Published: October 2023

Hasil penelitian St. Aminah dkk (2014), menemukan bahwa dari 30 ibu hampir seimbang antara pengetahuan baik (48 %) dan pengetahuan kurang (52%) pada ibu, mengetahui tentang keselamatan pada anaknya khususnya usia 5 tahun kebawah, di RW 03 Kelurahan Karunrung Kec. Rappocini kota Makassar. dengan paparan tersebut maka peneliti tertarik untuk melakukan penelitian tentang “Model Edukasi Melalaui Panduan Child Safety pada Keluarga di Kota Makassar” tujuan penelitian ini 1)Tercipta panduan yang efektif dan praktis untuk digunakan keluarga dalam menjaga keselamatan anak di dalam dan di sekitar rumah, 2)Meningkatkan pengetahuan keluarga dalam menjaga keselamatan anak di dalam dan di sekitar rumah, 3)Keluarga dapat menerapkan keselamatan anak di dalam dan di sekitarnya mengevaluasi pengaruh panduan terhadap anak secara fisik setelah penerapan panduan child safety dilaksanakan oleh keluarga “Penelitian Pengembangan” (Research and Development). Menurut Borg and Gall. Rumusan desain yang digunakan untuk menguji keefektifan model adalah dengan mengunakan desain penelitian. "Intact Group Comparison". Metode ini adalah Quasi eksperimen.hasil penelitian menunjukkan 1) Tercipta buku panduan keluarga yang efektif dan praktis, sebagai buku panduan keluarga dalam mencegah dan menangani kecelakaan pada anak, 2)Terjadi peningkatan pengetahuan keluarga tentang pencegahan dan penanganan kecelakaan pada anak, melalui pelatihan dengan buku panduan keluarga “child safety”, 3) Terjadi perubahan sikap keluarga menjadi positif tentang pencegahan dan penanganan kecelakaan pada anak, setelah memahami materi pada buku panduan keluarga “child safety” 4)Ada perbedaan yang signifikan antara pengetahuan dan sikap keluarga sebelum dilakukan pelatihan dan pemberian materi buku panduan keluarga “ child safety” dengan sesudah pelatihan atau pemberian materi melalui buku dan penjelasan secara langsung. Kata kunci : Panduan, child safety, keluarga
EDUKASI KADER KESEHATAN UNTUK PENJARINGAN IMUNISASI TETANUS TOXOID PADA IBU HAMIL DAN WANITA USIA SUBUR DI WILAYAH KERJA PUSKESMAS MANGASA KOTA MAKASSAR
Authors: Dalle Ambo , Jaya Ningsih , Yakub Alfi Syahar , Saini Sukma , Bahtiar Bahtiar 
Published: October 2023

Latar Belakang : Calon pengantin dan ibu hamil sebagai sasaran MNTE ternyata dalam pencapaian targetnya dirasakan agak lambat, sehingga diperlukan akselerasi berupa pemberian Tetanus Toksoid (TT) pada wanita usia subur (usia 15 – 39 tahun) termasuk ibu hamil. Kematian ibu dan kematian bayi, dapat disebabkan oleh infeksi bakteri Clostridium tetani yang mengakibatkan tetanus. Asumsi tim pengabmas bahwa salah satu kunci keberhasilan imunisasi TT ditentukan oleh kader kesehatan meskipun beberapa faktor lainnya diduga turut berkontribusi dalam pelaksanaan imunisasi TT. Tujuan pelaksanaan adalah untuk meningkatkan pengetahuan kader tentang imunisasi TT ibu hamil dan wanita usia subur dan meningkatkan kemampuan kader mensosialisasikan imunisasi TT. Metode : Metode yang digunakan melalui pendidikan kesehatan dan demosntrasi. Kegiatan dibagi 2 tahap dengan melibatkan 20 orang kader kesehatan. Kegiatan pengabdian pada masyarakat dilakukan di Puskesmas Mangasa Kota Makassar pada tanggal 7 April dan 8 Juni 2021. Hasil kegiatan menunjukkan bahwa hasil pre test terdapat 5 (25%) orang kader yang memiliki nilai ≤60% dari jumlah jawaban yang benar, sisanya 15 (75%) memiliki nilai >60% dari jumlah jawaban yang benar. Selain itu, kegiatan post test terdapat 20 (100%) orang kader yang memperoleh nilai > 60%. Kesimpulan kegiatan yaitu terjadi peningkatan pengetahuan dan ketrampilan kader tentang imunisasi Tetanus Toxoid pada wanita usia subur dan ibu hamil. Rata-rata hasil pre test dari kader kesehatan adalah 73,67% yang mengalami peningkatan menjadi 86,7% pada saat post test. Artinya terdapat sekitar rata-rata 13% peningkatan nilai pre test - Post Test kader kesehatan. Kata Kunci : Edukasi, Kader, Imunisasi Tetanus Toxoid, Ibu Hamil, Wanita Usia Subur
UJI EFEKTIVITAS SARI DAUN PERIA (Momordica Charantia) TERHADAP MORTALITAS JENTIK AEDES AEGYPTI
Authors: Rostina Rostina , Kasim Khiki Purnawati , Awaliyah Azmi 
Published: October 2023

Demam Berdarah Dengue (DBD) masih merupakan salah satu masalah kesehatan masyarakat yang utama di Indonesia. Jumlah penderita dan luas daerah penyebarannya semakin bertambah seiring dengan meningkatnya mobilitas dan kepadatan penduduk, maka dari itu perlu dilakukan pengendalian dan pembasmian terhadap vektor melalui pembrantasan jentik Aedes aegypti dengan menggunakan larvasida alami. Daun peria memiliki zat aktif yang terkandung didalamnya yaitu flavonoid, saponin dan alkaloid memiliki sifat antimikroba dan insektisida dalam mekanisme larvasida. Tujuan penelitian untuk mengetahui efektivitas sari daun peria terhadap mortalitas jentik Aedes aegypti, dengan menggunakan indikator penilaian sesuai panduan Permenkes No. 50 Tahun 2017 untuk penelitian ini menggunakan 320 ekor jentik dengan 3 kali pengulangan dengan menggunakan konsentrasi 10%, 20%, 30%, dan Kontrol (0%). Hasil penelitian menunjukkan rata rata kematian jentik konsentrasi 10% ialah 9 ekor jentik atau 45%, konsentrasi 20% ialah 19 ekor jentik atau 95%, konsentrasi 30% ialah 20 ekor jentik atau 100%. Sebelum dan setelah penelitian dilakukan pengukuran suhu dan kelembaban dan didapatkan hasil rata rata suhu ialah 28,5 °C dan rata rata kelembaban ialah 83%. Kesimpulan penelitian menggunakan sari daun peria dengan konsetrasi 20% dan 30% efektif terhadap mortalitas jentik Aedes aegypti dan konsentrasi 10% tidak efektif, disarankan masyrakat menggunakan konsentrasi 20% karena efektif terhadap mortalitas jentik Aedes agypti dan memanfaatkan daun peria (Momordica Chrantia) sebagai insektisida alami karena mudah didapatkan dan sangat sederhana cara pembuatannya serta ramah lingkungan.Kata kunci: Efektivitas, Jentik Aedes aegypti, Sari Daun Peria
Low sludge yield biofilm activated sludge (BAS) upgrade – Quesnel River Pulp
Authors: RANKIN ANNA , VAN AERT MICHAEL , WELANDER THOMAS , MALMQVIST ASA 
Published: October 2023

Quesnel River Pulp (QRP) began operating a low sludge yield biofilm activated sludge (BAS) treatment system at its bleached chemithermomechanical (BCTMP) pulp mill at Quesnel, British Columbia, in March 2005. AnoxKaldnes provided the technology. QRP upgraded the anaerobic/activat-ed sludge treatment (AST) system to allow for both increased production rates, as well as production of higher load grades of pulp. The system increased treatment capacity from 110 tons soluble chemical oxygen demand (SCOD)/day to 140 tons SCOD/day with expansion capacity to 170 tons SCOD/day. In addition, the anaerobic system capable of removing 20 tons SCOD/day could be decommissioned since it had a low tolerance for peroxide and sulfur, and high maintenance and operating costs. Results of the upgrade included:
1)	meeting all permit limits and effluent is nontoxic to trout under standard test conditions,
2)	80%–85% SCOD removal,
3)	stable and reliable operation,
4)	sludge yields between 0.12–0.17 net kg total suspended solids (TSS)/kg SCOD removed (compared to previous yields of 0.23 net kg TSS/kg SCOD removed), and
5) ~25% decrease in total effluent treatment costs per ton of pulp, despite a 30% increase in power requirements.
A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator
Authors: Izquierdo-Vega Jeannett Alejandra , Castillo-Juarez Rubi Joseline , Sánchez-Gutiérrez Manuel , Ares Miguel A. , De La Cruz Miguel A. 
Published: October 2023

Abstract
Enteroaggregative Escherichia coli (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly resistant to antibiotics. As part of the pathophysiology of EAEC, the characteristic pattern of adherence looks like stacked bricks on the intestinal epithelium. This phenotype depends on an aggregative adhesion plasmid (pAA), which codes for a regulatory protein named AggR. The AggR protein is a master regulator that transcriptionally actives the main virulence genes in this E. coli pathotype, such as those that encode the aggregative adhesion fimbriae, dispersin and its secretion apparatus, Aar regulatory protein, and type VI secretion system. Several reports have shown that AggR positively affects most EAEC virulence genes, functioning as a classic transcriptional activator in the promoter region of these genes, interacting with the RNA polymerase. This minireview article integrates the information about virulence determinants of EAEC controlled by the AggR regulator.
Global Approach on the Shear and Cross Tension Strength of Resistance Spot Welded Thin Steel Sheets
Authors: Májlinger Kornél , Katula Levente T. , Varbai Balázs 
Published: October 2023

Several correlations from the professional literature describing the shear and cross tension strength (STS and CTS) of resistance spot welded (RSWed) thin steel sheets were investigated. Some of them need chemical composition or weld nuggets strength hardness as input parameters, making them hardly applicable in the planning stage of the joints. Using STS and CTS data collected from over 250 papers, selected correlations were tested, whether they are applicable to predict the STS and CTS of the RSWed joints at the planning stage to help designers plan their static-loaded welds strength. Most correlations had limitations in the applicable base materials' tensile strength range. Therefore, new equations for STS and CTS are proposed, which can be used to plan in the 300–18900 MPa base metals tensile strength range for similar and dissimilar RSWed joints of thin steel sheets.
Exploring the disruption of SARS-CoV-2 RBD binding to hACE2
Authors: Carter Camryn , Airas Justin , Gladden Haley , Miller Bill R. , Parish Carol A. 
Published: October 2023

The COVID-19 pandemic was declared due to the spread of the novel coronavirus, SARS-CoV-2. Viral infection is caused by the interaction between the SARS-CoV-2 receptor binding domain (RBD) and the human ACE2 receptor (hACE2). Previous computational studies have identified repurposed small molecules that target the RBD, but very few have screened drugs in the RBD–hACE2 interface. When studies focus solely on the binding affinity between the drug and the RBD, they ignore the effect of hACE2, resulting in an incomplete analysis. We screened ACE inhibitors and previously identified SARS-CoV-2 inhibitors for binding to the RBD—hACE2 interface, and then conducted 500 ns of unrestrained molecular dynamics (MD) simulations of fosinopril, fosinoprilat, lisinopril, emodin, diquafosol, and physcion bound to the interface to assess the binding characteristics of these ligands. Based on MM-GBSA analysis, all six ligands bind favorably in the interface and inhibit the RBD–hACE2 interaction. However, when we repeat our simulation by first binding the drug to the RBD before interacting with hACE2, we find that fosinopril, fosinoprilat, and lisinopril result in a strongly interacting trimeric complex (RBD-drug-hACE2). Hydrogen bonding and pairwise decomposition analyses further suggest that fosinopril is the best RBD inhibitor. However, when lisinopril is bound, it stabilizes the trimeric complex and, therefore, is not an ideal potential drug candidate. Overall, these results reveal important atomistic interactions critical to the binding of the RBD to hACE2 and highlight the significance of including all protein partners in the evaluation of a potential drug candidate.
Monthly versus daily administration of vitamin D3 in children: a retrospective propensity score-matched study
Authors: Choi Jinjoo , Choe Yunsoo , Yang Seung 
Published: October 2023

ObjectivesWe aimed to evaluate the efficacy and safety of monthly vitamin D3 administration compared to a daily dosing regimen in healthy children with vitamin D deficiency.MethodsThis retrospective study included vitamin D deficient (serum 25-hydroxyvitamin D [25(OH)D] &lt; 20 ng/mL) children with precocious puberty who received gonadotropin-releasing hormone agonist every 4 weeks between December 2019 and November 2022. We used propensity scores to 1:1 match daily (1,000 IU daily) and monthly (25,000 IU per 4 weeks) administration of vitamin D3 based on age, sex, body mass index Z-scores, season of blood collection, and baseline serum 25(OH)D concentrations.ResultsOf 299 children, 192 were matched based on propensity scores (126 girls and 66 boys, 10.5 ± 1.4years). After a mean follow-up of 5.9 months (standard deviation [SD] 2.5 months), the monthly group showed a statistically significant increase in serum 25(OH)D concentrations (10.9 ± 5.3 vs. 8.2 ± 7.2 ng/mL; p = 0.018), higher corrected dose-response (12.3 ± 5.9 vs. 8.2 ± 7.2 ng/mL increase per 1,000 IU daily; p = 0.002), and a higher proportion of patients attaining 25(OH)D &gt; 20 ng/mL (78.1% vs. 58.3%,; p=0.005) compared with the daily group. No cases of hypercalcemia were observed in either group.ConclusionsMonthly administration of vitamin D3 may be an effective and safe alternative to correct hypovitaminosis D in pediatric population, possibly attributed to enhanced compliance.
Frictional performance of chemically modified cottonseed-based fossil-free biolubricant oil in a sliding tribopair
Authors: Ghumman I. S. S. , Afaq S. K. , Usman Ali 
Published: October 2023

In this study, the tribological properties of a green lubricant synthesized from cottonseed oil through a two-step transesterification process are investigated, with a specific focus on the maximum throughput of the second step that involves the reaction of cottonseed methyl ester with 2-ethyl-1-hexanol alcohol and a titanium isopropoxide (TIS) catalyst. The research centers on evaluating the physiochemical characteristics of this biolubricant and comparing them with those of commercial oil (5W30) and the ISO VG40 standard. Furthermore, the influence of crucial process variables, such as temperature, pressure, reaction time, and TIS catalyst concentration, is examined by analyzing variance in experimental data. Fourier transform infrared (FTIR) analysis is employed to identify functional groups, particularly emphasizing the impact of temperature and reaction time. By optimizing the second transesterification process under specific conditions (pressure = 19.42 mmHg, temperature = 175°C, catalyst concentration = 0.63%, and reaction time = 4.0 h), a cottonseed oil-based biolubricant is successfully produced, exhibiting properties comparable to those of commercial mineral lubricants. Notably, the findings reveal significant enhancements in the coefficient of friction (CoF) with a 49% reduction and wear resistance with a maximum 19% reduction. This study contributes valuable insights into optimizing biolubricant production derived from cottonseed oil through two-step transesterification, emphasizing its novel potential in improving frictional and wear characteristics.
Medical students’ perceptions of LGBTQ+ healthcare in Singapore and the United Kingdom
Authors: Fu Michael X. , Zou Tangming , Aiyappan Raksha , Ye Xinyu , Onanuga Simisola , Tan Angela , Smith Susan , Baptista Ana 
Published: October 2023

IntroductionLesbian, gay, bisexual, transgender, queer, and other sexual and gender minority (LGBTQ+) individuals have an increased scope of healthcare needs and face many barriers to accessing healthcare. However, LGBTQ+ healthcare education remains scarce, and students’ understanding of LGBTQ+ healthcare remains largely uncharacterised. This study investigated the knowledge of and attitudes toward LGBTQ+ healthcare among medical students in Singapore and the United Kingdom (UK), two culturally different countries.MethodsMedical students in two medical schools, one in Singapore and the other in the UK, completed self-administered cross-sectional surveys using multiple-choice, Likert scale, and free-text questions to explore their ideas, concerns, and expectations about LGBTQ+ healthcare education within their medical curricula.ResultsFrom 330 responses, students’ knowledge levels were moderate overall, with pronounced gaps in certain areas, including terminology, sexual health, and conversion therapy. Deficiencies in knowledge were significantly greater among students in Singapore compared to the UK (p &lt; 0.001), whilst LGBTQ+ students and non-religious students had more positive knowledge and attitudes than students not identifying. At least 78% of students had positive attitudes towards LGBTQ+ individuals, but 84% had not received LGBTQ+-specific medical education. Although junior UK students were more satisfied with the adequacy of teaching by their medical school’s incorporation of LGBTQ+ inclusive teaching in a newer curriculum, qualitative analyses suggested that students in both countries wanted to receive more training. Students further suggested improvements to the medical curriculum to meet their needs.ConclusionStudents in both schools lacked understanding of commonly-used terminology and topics such as sexual healthcare despite affirming attitudes towards LGBTQ+ healthcare. Although sociolegal contexts may affect students’ perspectives, differences were less than thought, and students were equally keen to provide affirmative care to their patients. They emphasised a need for more formal teaching of LGBTQ+ healthcare professions to overcome healthcare disparities in these communities.
Coffee consumption and all-cause and cardiovascular mortality in older adults: should we consider cognitive function?
Authors: Lin Fabin , Shi Yisen , Zou Xinyang , Wang Huaicheng , Fu Shibo , Wang Xuefei , Yang Zeqiang , Cai Guofa , Cai Guoen , Wu Xilin 
Published: October 2023

BackgroundThe association between coffee and mortality risk has been found in most previous studies, and recent studies have found an association between coffee consumption and cognition. However, there is still a lack of research exploring whether the association between coffee and mortality is influenced by cognitive function.ObjectiveThe purpose of this study was to explore the association of coffee, caffeine intake in coffee and decaffeinated coffee with all-cause mortality and cardiovascular disease (CVD) mortality in older adults with different cognitive performances.MethodsThe study was based on data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Coffee and caffeine consumption data were obtained from two 24-h dietary recalls. Individual cognitive functions were assessed by CERAD-word learning test (CERAD-WLT), animal fluency test (AFT), and digit symbol substitution test (DSST). In addition, principal component analysis (PCA) was performed with the above test scores to create global cognitive score. The lowest quartile of scores was used to classify cognitive performance. Cox regression and restricted cubic spline (RCS) were applied to assess the relationship between coffee and caffeine consumption and mortality.ResultsIn the joint effects analysis, we found that those with cognitive impairment and who reported without drinking coffee had the highest risk of all-cause and cardiovascular mortality compared with others. In the analysis of population with cognitive impairment, for all-cause mortality, those who showed cognitive impairment in the AFT displayed a significant negative association between their total coffee consumption and mortality {T3 (HR [95% CI]), 0.495 [0.291–0.840], p = 0.021 (trend analysis)}. For DSST and global cognition, similar results were observed. Whereas for CERAD-WLT, restricted cubic spline (RCS) showed a “U-shaped” association between coffee consumption and mortality. For CVD mortality, a significant negative trend in coffee consumption and death was observed only in people with cognitive impairment in AFT or DSST. In addition, we observed that decaffeinated coffee was associated with reduced mortality in people with cognitive impairment.ConclusionOur study suggested that the association between coffee consumption and mortality is influenced by cognition and varies with cognitive impairment in different cognitive domains.
Collagen-I influences the post-translational regulation, binding partners and role of Annexin A2 in breast cancer progression
Authors: Mahdi Amira F. , Nolan Joanne , O’Connor Ruth Í. , Lowery Aoife J. , Allardyce Joanna M. , Kiely Patrick A. , McGourty Kieran 
Published: October 2023

IntroductionThe extracellular matrix (ECM) has been heavily implicated in the development and progression of cancer. We have previously shown that Annexin A2 is integral in the migration and invasion of breast cancer cells and in the clinical progression of ER-negative breast cancer, processes which are highly influenced by the surrounding tumor microenvironment and ECM.MethodsWe investigated how modulations of the ECM may affect the role of Annexin A2 in MDA-MB-231 breast cancer cells using western blotting, immunofluorescent confocal microscopy and immuno-precipitation mass spectrometry techniques.ResultsWe have shown that the presence of collagen-I, the main constituent of the ECM, increases the post-translational phosphorylation of Annexin A2 and subsequently causes the translocation of Annexin A2 to the extracellular surface. In the presence of collagen-I, we identified fibronectin as a novel interactor of Annexin A2, using mass spectrometry analysis. We then demonstrated that reducing Annexin A2 expression decreases the degradation of fibronectin by cancer cells and this effect on fibronectin turnover is increased according to collagen-I abundance.DiscussionOur results suggest that Annexin A2's role in promoting cancer progression is mediated by collagen-I and Annexin A2 maybe a therapeutic target in the bi-directional cross-talk between cancer cells and ECM remodeling that supports metastatic cancer progression.