bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value dissonance in research(er) assessment: individual and perceived institutional priorities in review, promotion, and tenure
Authors: Ross-Hellauer Tony , Klebel Thomas , Knoth Petr , Pontika Nancy 
Published: November 2023

Abstract
There are currently broad moves to reform research assessment, especially to better incentivize open and responsible research and avoid problematic use of inappropriate quantitative indicators. This study adds to the evidence base for such decision-making by investigating researcher perceptions of current processes of research assessment in institutional review, promotion, and tenure processes. Analysis of an international survey of 198 respondents reveals a disjunct between personal beliefs and perceived institutional priorities (‘value dissonance’), with practices of open and responsible research, as well as ‘research citizenship’ comparatively poorly valued by institutions at present. Our findings hence support current moves to reform research assessment. But we also add crucial nuance to the debate by discussing the relative weighting of open and responsible practices and suggesting that fostering research citizenship activities like collegiality and mentorship may be an important way to rebalance criteria towards environments, which better foster quality, openness, and responsibility.
Anthropause on tardigrade urban communities during COVID-19 pandemic restrictions in Salta, Argentina
Authors: González-Reyes Andrea , Grabosky Alfonsina , Rocha Mariana , Ballardini Florentina , Ostertag Belén , Rodríguez-Artigas Sandra , Fernández Daniel , Corronca José 
Published: November 2023

Abstract
The World Health Organization declared COVID-19 a pandemic on 11 March 2020. The ‘anthropause’ almost emptied our streets of vehicles. In urban areas, automobile traffic is a major environmental factor, and tardigrades can serve as bioindicators of environmental change. During the winter of 2019–2020, samples were taken both before and during the COVID-19 lockdown. In both cases, traffic variables (vehicles per minute), environmental variables, and microhabitats were evaluated. Both before and after the COVID-19 lockdown, the true species diversity and the β-diversity of each habitat and habitat pair were compared. The indicator value method identified species that served as indicators of habitat. Although species richness increased during the anthropause, abundance decreased, as evidenced by the discovery of previously unknown species of Paramacrobiotus and Milnesium in 2020 and by the first record of Mesobiotus in the same year. Different variables were affected in different ways by the decline in vehicular traffic that occurred during the anthropause. Compared to the other examined traffic conditions, the behaviour of the variables was distinct in medium traffic, resulting in more stable conditions. Patterns of nested urban diversity might produce reversible gradients over time. Between habitats with high vehicular traffic and those with medium vehicular traffic, the greatest loss of species occurs.
Diagnostic Yield of Exome Sequencing in Isolated Fetal Growth Restriction: Systematic Review and Meta-analysis
Authors: Pauta M. , Martinez-Portilla R. J. , Meler E. , Otaño J. , Borrell A. 
Published: November 2023

(Abstracted from Prenat Diagn 2023;43:596–604)
An estimate of fetal weight below a certain percentile is defined as fetal growth restriction (FGR); different medical organizations define the threshold for FGR differently. Regardless of the definition used, long-term adverse outcomes have been associated with FGR, such as an increased risk of neurodevelopmental delay, along with other, short-term adverse outcomes.
Association of Body Mass Index With Early Age at Diagnosis of Endometrial Intraepithelial Neoplasia
Authors: Nicholson Kaitlin , Macharia Annliz , Furuya Rachel , Manning Chelsea , Hacker Michele R. , Harris Devon A. , Esselen Katharine , Dottino Joseph 
Published: November 2023

(Abstracted from Gynecol Oncol 2023;175:15–19)
The development of endometrial intraepithelial neoplasia (EIN), a precursor lesion to endometrioid endometrial cancer, is related to prolonged and unopposed excess estrogen stimulation in the endometrium. The 2 conditions are frequently diagnosed concurrently.
Nonestrogen Therapies for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review
Authors: Casiano Evans Elizabeth A. , Hobson Deslyn T. G. , Aschkenazi Sarit O. , Alas Alexandriah N. , Balgobin Sunil , Balk Ethan M. , Dieter Alexis A. , Kanter Gregory , Orejuela Francisco J. , Sanses Tatiana V. D. , Rahn David D. 
Published: November 2023

(Abstracted from Obstet Gynecol 2023;1(00):00)
Genitourinary symptoms of menopause (GSMs) are common and include vaginal dryness, discomfort and dyspareunia, and urinary urgency and frequency. Women often do not seek treatment, although commercially available local estrogen products have been shown to be effective.
Programmed Intermittent Bolus for Erector Spinae Plane Block versus Intercostal Nerve Block with Patient-controlled Intravenous Analgesia in Video-assisted Thoracoscopic Surgery
Authors: Wang Tian , Wang Xuedong , Yu Zhuoying , Li Min 
Published: November 2023

Objective:
Postoperative analgesia is crucial after video-assisted thoracoscopic surgery (VATS). This study was designed to investigate whether the analgesic effect of programmed intermittent bolus erector spinae plane block (ESPB) is non-inferior to that of intercostal nerve block with patient-controlled intravenous analgesia (ICNB-PCIA) for VATS.

Methods:
The study was designed as a single-center, open labelled, randomized non-inferiority trial. A total of 80 patients (ASA I–III) undergoing elective video-assisted thoracoscopic lobectomy or bulla resection were randomly allocated to the ICNB-PCIA (n=40) or the ESPB (n=40) group using a programmed intermittent bolus (PIB) injection. The primary outcome was pain intensity at movement at 4 h postoperatively using the Numeric Rating Scale (NRS). Secondary outcomes included pain scores at rest and movement in the recovery room, at 8, 24, and 48 h postoperatively, perioperative analgesics, adverse effects, hospital stay and patient satisfaction.

Results:
The mean difference in NRS scores at movement at 4 h postoperatively between the ESPB (n=39) and the ICNB-PCIA (n=37) groups was under the non-inferiority margin. NRS scores were significantly higher in the ICNB-PCIA group than the ESPB group at movement postoperatively. At rest, NRS scores were significantly elevated in the ICNB-PCIA at 4 h, 8 h and at 24 h. The postoperative opioids consumption was decreased in the ESPB group. No difference was found in rescue analgesics, hospital stay and patient satisfaction.

Discussion:
ESPB using a PIB injection offers non-inferior analgesia to ICNB with PCIA after VATS.
Multidetector computed tomography evaluation of obstructive jaundice: a cross-sectional study from a tertiary hospital of Nepal
Authors: Khadka Sujan , Mahat Asim , Yadav Gopal K. , Thapa Priya , Mishra Upama , Bhattarai Manoj , Awale Laligen , Pradhan Anju , Gupta Mukesh K. 
Published: November 2023

Background:
The utilization of advanced multidetector computed tomography (MDCT) technology along with postprocessing reconstruction techniques has significantly enhanced the clarity of visualization of the hepato-biliary tree. Therefore, this study was conducted to evaluate the diagnostic statistics of MDCT and its associated features in the evaluation of obstructive jaundice, with respect to surgical or histopathological diagnoses.

Methods and methodology:
The authors conducted a cross-sectional study among 30 participants with obstructive jaundice using purposive sampling. The authors calculated the diagnostic statistics of non-neoplastic and neoplastic types, along with specific etiologies of obstructive jaundice identified through MDCT using a statistical package for social sciences (SPSS) v21 and MedCalc v12.3.0. The ethical clearance was obtained from the institutional review committee of BPKIHS, Nepal (Ref no: Acd/291/075/076-IRC).

Results:
The sensitivity and the negative predictive value of MDCT for non-neoplastic cause to detect obstructive jaundice were 100% (95% CI: 79.41–100.00) and 100% (95% CI: 75.29–100.00), while the specificity and the positive predictive value for neoplastic cause to detect obstructive jaundice were 100% (95% CI: 79.41–100.00) and 100% (95% CI: 75.29–100.00), respectively. Similarly, the accuracy for either non-neoplastic or neoplastic cause was 96.67% (95% CI: 82.78–99.92). The most common cause of obstructive jaundice was choledocholithiasis (33.34%) followed by cholangiocarcinoma (20%), ampullary carcinoma (13.33%), and choledochal cyst (13.33%). The diagnostic accuracy of the individual etiology of common causes of obstructive jaundice ranged from 82.78 to 100%. Biliary obstruction was most frequently observed in the periampullary region (83.33%), followed by the proximal common bile duct (6.67%), hilar region (6.67%), and intrahepatic region (3.33%).

Conclusion:
The MDCT could serve as the initial and time-efficient excellent imaging modality for diagnosing various causes of obstructive jaundice with greater accuracy. It can differentiate non-neoplastic from neoplastic causes of obstructive jaundice.
Electrochemotherapy in plastic surgery: New perspectives from the pandemic experience in the treatment of advanced skin cancers in elderly and frail patients
Authors: Bonadies Antonio , Marcasciano Marco , Nanni Jacopo , Tedesco Marinella , Pallara Tiziano , Govoni Flavio Andrea , Grippaudo Francesca Romana , Greco Manfredi , Migliano Emilia 
Published: November 2023

Background:
During the COVID-19 pandemic, most of the surgical units involved in the treatment of skin cancers could continue their activities, but the reevaluation of cases and the adaptation of the surgical approach, to limit access and hospital stays, proved to be mandatory. The study aims to demonstrate how the electrochemotherapy (ECT) approach guarantees a chance to keep on delivering comprehensive oncologic surgical treatment in a difficult and high-risk cohort of patients.

Methods:
We collected 35 elderly and frail patients affected by advanced and metastatic skin cancer who were unsuitable for a standard surgical approach. They were submitted to an ECT protocol, while evaluating the impact of ECT on health-related quality of life, using the EuroQol–five dimensions–three levels (EQ-5D-3L) instrument at baseline and after treatment.

Results:
A general improvement in health status was reported from the preoperative (mean 56.9) to the postoperative period (mean 63.7), according to the EuroQol–visual analog scale measure. The EuroQol–five dimensions descriptive system showed a reduction of the “patients reporting problems” from the baseline, in the domains for self-care (−27%), usual activities (−24%), pain/discomfort (−43%), and anxiety/depression (−11%).

Conclusions:
Rapid intervention, minimum hospitalization, palliation in selected cases, and postoperative management with telemedicine may represent the only option in the hands of a surgeon to treat advanced oncologic lesions in fragile patients, especially in a pandemic scenario. ECT can be considered a safe and effective procedure, well tolerated by most elderly and “high-risk” patients.
Comparison of Efficacy of Micropulse and Continuous Wave Cyclophotocoagulation in Patients With Pediatric Glaucoma
Authors: Vega-Garces Maria , Uppuluri Siri , Oydanich Marko , Khouri Albert S. 
Published: November 2023

Précis:
Both micropulse (MP-CPC) and continuous wave (CW-CPC) cyclophotocoagulation exhibited short-term effectiveness in lowering IOP, followed by reversion to near baseline levels 12 months after laser treatment.

Objective:
To determine and compare the effectiveness and safety of MP-CPC and CW-CPC in patients diagnosed with pediatric glaucoma.

Methods:
A retrospective cohort study was conducted on a total of 28 patients (81 eyes) diagnosed with pediatric glaucoma either undergoing MP-CPC or CW-CPC. Intraocular pressure (IOP) measurements, number of glaucoma medications, and the onset of complications were collected at baseline, 1-month, 3-month, 6-month, and 12-month intervals. Success rate (SR) was defined as eyes achieving IOP ≤21 mm Hg and ≥5 mm Hg and a 20% reduction in IOP at the last follow-up visit.

Results:
All patients either undergoing MP-CPC or CW-CPC were matched for age (mean ± SD; 1.76 ± 1.69 vs 1.56 ± 2.49 y). Patients undergoing MP-CPC had significant decreases in IOP from baseline IOP at 1, 3, and 6 months with a 22% SR at 12 months. CW-CPC had a significant decrease in IOP from baseline IOP at all follow-ups, with a 27% SR at 12 months. At the 12-month follow-up, the CW-CPC cohort exhibited a significantly larger overall drop in IOP when compared with the MP-CPC cohort, (7.99 ± 7.95 vs 1.78 ± 6.89, P < 0.05); however, the difference in SR between treatment groups (27% vs 22%) at 12 months was not significant (P > 0.05). Complications were minimal for both groups.

Conclusion:
Both MP-CPC and CW-CPC exhibited short-term effectiveness in lowering IOP, followed by reversion to near baseline levels 12 months after laser treatment. Both MP-CPC and CW-CPC exhibited similar SR at 12 months, 22% and 27% respectively.
Nerve–myeloid cell interactions in persistent human pain: a reappraisal using updated cell subset classifications
Authors: O'Brien Jayden A. , Karrasch Jackson F. , Huang Yun , Vine Erica E. , Cunningham Anthony L. , Harman Andrew N. , Austin Paul J. 
Published: November 2023

Abstract
The past 20 years have seen a dramatic shift in our understanding of the role of the immune system in initiating and maintaining pain. Myeloid cells, including macrophages, dendritic cells, Langerhans cells, and mast cells, are increasingly implicated in bidirectional interactions with nerve fibres in rodent pain models. However, our understanding of the human setting is still poor. High-dimensional functional analyses have substantially changed myeloid cell classifications, with recently described subsets such as epidermal dendritic cells and DC3s unveiling new insight into how myeloid cells interact with nerve fibres. However, it is unclear whether this new understanding has informed the study of human chronic pain. In this article, we perform a scoping review investigating neuroimmune interactions between myeloid cells and peripheral nerve fibres in human chronic pain conditions. We found 37 papers from multiple pain states addressing this aim in skin, cornea, peripheral nerve, endometrium, and tumour, with macrophages, Langerhans cells, and mast cells the most investigated. The directionality of results between studies was inconsistent, although the clearest pattern was an increase in macrophage frequency across conditions, phases, and tissues. Myeloid cell definitions were often outdated and lacked correspondence with the stated cell types of interest; overreliance on morphology and traditional structural markers gave limited insight into the functional characteristics of investigated cells. We therefore critically reappraise the existing literature considering contemporary myeloid cell biology and advocate for the application of established and emerging high-dimensional proteomic and transcriptomic single-cell technologies to clarify the role of specific neuroimmune interactions in chronic pain.
The effects of empathic communication skills training on nurse practitioner students
Authors: Beckstrom Kimberly M. , Farrow Stacy L. 
Published: November 2023

ABSTRACT
Evidence regarding the impact of empathic communication training on nurse practitioner (NP) students is lacking. Despite increasing emphasis within practice settings in the United States, formal communication training for NP students has been modestly integrated into curriculum, based on limited data supporting its efficacy. As such, we sought to evaluate the impact of empathic communication training on NP students' self-efficacy with empathic communication. This is a quasi-experimental study of a single group of NP students (n = 49) who participated in empathic communication training with pretraining/posttraining measurements using the Self-Efficacy-12 instrument. There were statistically significant improvements in students' comfort and confidence with nine of the 17 items surveyed. Several other domains also showed improvement approaching statistical significance. Based on our results, empathic communication training increases NP students' self-efficacy with empathic communication.
Defining Optimal Settings for Lung Cryobiopsy in End-Stage Pulmonary Disease. A Human, Ex Vivo, Diseased Lung Clinical Trial
Authors: Menezes Vanessa , Pollock Clare , Ferraro Pasquale , Nasir Basil , Leduc Charles , Morisset Julie , Liberman Moishe 
Published: November 2023

Background:
To evaluate optimal settings of probe size, freezing time, and distance to the pleura that influence the size and quality of biopsy specimens during transbronchial lung cryobiopsies in ESPD.

Methods:
We prospectively recruited 17 patients undergoing lung transplantation. We created a nonperfused ex vivo bronchoscopy setting to perform multiple cryobiopsies with different probe sizes (1.7, 1.9, and 2.4 mm), freezing times (3, 5, 7, 10, 20, 30 seconds), and probe distance from pleura (5, 10, and 20 mm). Alveolated pulmonary parenchyma area≥50% in histology was considered a good quality biopsy, with a minimum procedural artifact. We used logistic regression to identify independent parameters as risk factors for histologic adequacy.

Results:
A total of 545 cryobiopsies were obtained from 34 explanted lungs after pneumonectomy for lung transplantation. The mean maximum diameter of the specimen achieved with the 1.7 probe was larger (13.5 mm) than those obtained with 1.9 and 2.4 mm probes (11.3 and 10.7 mm, P=0.07). More pleural macroscopic damage and pleural tissue in histology occurred with the 2.4 mm probe (P<0.001). There was no difference in the quality of specimens between the different freezing times and the distance from the pleura.

Conclusions:
Freezing time and distance from the pleura did not affect the histologic quality for diagnosing ESPD in severely damaged lungs. Smaller cryoprobe size did not negatively affect sample adequacy.
School-based health: an area of opportunity to address challenges in management of pediatric obesity and type 2 diabetes
Authors: Wood Aurelia C.H. , Pratt Keeley 
Published: November 2023

Purpose of review
Obesity and type 2 diabetes (T2D) are increasingly common, chronic, and complex and disproportionally affect systemically under-resourced communities negatively impacted by social determinants of health. The primary goals of management for both conditions are improvement of medical and psychosocial well being and prevention of secondary complications. The advent of pediatric specific multidisciplinary weight management programs, bariatric surgery, and recent FDA approved medications have provided clinicians with tools to improve patient outcomes. However, implementation remains a challenge.

Recent findings
The Chronic Care Model proposes utilization of community-based interventions to support children and families in managing chronic disease The CDC's Whole School, Whole Community, Whole Child Model provides a framework for schools to engage in this role. School-Based Health Centers (SBHCs) utilize a child-focused, multidisciplinary approach to support the medical home and overcome barriers to routine primary care, medical screenings and successful care plans for management of chronic disease. SBHCs and school-based programs have proven sustainable and effective in addressing obesity and T2D in youth, however recent studies are limited and more research evaluating impact are needed.

Summary
School-based health offers an evidence-based solution to ensuring equitable and comprehensive care for obesity and T2D, particularly among at-risk communities.
Incidence of incisional hernias and cosmetic outcome after laparoscopic single-incision cholecystectomy: a long-term follow-up cohort study of 125 patients
Authors: Krollmann Niklas , Hunger Richard , Paasch Christoph , Mantke René 
Published: November 2023

Background:
Studies have evaluated long-term occurrence of incisional hernia, cosmesis, and postoperative pain after single-incision laparoscopic cholecystectomy (SILC). However, the follow-up periods were rarely defined longer than 12 months. The authors performed a cohort study to evaluate hernia rate and cosmesis in a prolonged follow-up period.

Methods:
All patients that underwent SILC at the University Hospital Brandenburg an der Havel Hospital between December 2008 and November 2014 were evaluated in terms of postoperative complications, and a follow-up telephone interview including the existence of hernias and chronic pain was performed. Cosmesis and the overall satisfaction of the scar was measured by POSAS (Patient and Observer Scar Assessment Scale).

Results:
In total 125 patients underwent SILC. The single-incision approach was completed in 94.4%, an additional trocar was necessary in 3.2% (n=4) and a conversion to 4 trocar cholecystectomy was required in 2.4% (n=3). Intraoperative complications occurred in 0.8% and postoperative complication in 12.8% of all patients. Follow-up telephone interview was performed in 49.6% of 125 patients. The mean follow-up period was 138.9 months (11.6 years). Overall, in 3.6%, an incisional hernia was diagnosed. A total of 3.6% reported pain in the region of the umbilicus with a mean VAS (visual analog scale) of 2/10. The mean POSAS score was 7.8. Overall, 82.3% of this cohort rate their satisfaction of the scar with a 1/7, resembling the best possible result of the scar.

Conclusion:
The present study demonstrates that SILC is a safe alternative in terms of incisional hernia rate and complications with a high satisfaction of the scar even after one decade after surgery. In comparison to shorter follow-up period and multiport laparoscopic cholecystectomy, our result is comparable.
Factors influencing bacterial colonization of double J ureteral stents: a prospective study
Authors: Bouassida Khaireddine , Marzouk Manel , Ben Saad Hamda , Khalfaoui Najd , Jaidane Mehdi , Boukadida Jalel , Zairi Amira 
Published: November 2023

Background:
To investigate the microorganisms responsible for double J stent (DJS) colonization, bacteriuria, and the drug susceptibility of the isolates. We also tried to determine factors associated with stent colonization, such as indwelling time, sex, age, and comorbidities.

Materials and methods:
This study is a prospective analysis of patients following DJS ablation. A total of 155 patients from our institution were enrolled in this study between January 2023 and May 2023. Bladder urine was collected in a sterile container prior to stent removal for bacteriological exam. The removed stents were divided into three parts: top (Renal), middle (Ureteral), and bottom (Bladder); 3 cm pieces from each part were taken and placed in a sterile test tube for bacteriological investigation.

Results:
The mean age of patients with positive stent culture was 61.17±12.82 versus 55.94±10.32 when stent culture is negative, which is statistically significant P=0.016. Diabetes and bacteriuria are both correlated with DJS contamination with P<0.001 in the two cases. The mean duration of the use of DJS in patients with colonized stent culture is 6.45±2.98 months versus 4.06±2.20 months for the other patients; the difference is statistically significant P<0.001. The most commonly isolated pathogens on stents were Gram-negative bacilli (53.2%), dominated by Enterobacteriaceae in 19 cases (55.2%).

Conclusion:
Indwelling time is the only unanimous factor of stent colonization in literature, so we recommend using DJS only if necessary and to remove it as soon as possible.