bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvent Annealing Enabling Reconstruction of Cadmium Sulfide Film for Improved Heterojunction Quality and Photovoltaic Performance of Antimony Selenosulfide Solar Cells
Authors: Gu Yuehao , Liang Wenhao , Che Yixuan , Cai Zhiyuan , Xiao Peng , Yang Junjie , Zang Runxuan , Wang Hong , Wu Xiaojun , Chen Tao 
Published: December 2023

AbstractAntimony selenosulfide, Sb2(S,Se)3, has been considered as new‐generation light‐harvesting material for high‐efficiency photovoltaic applications due to its adjustable bandgap, high absorption coefficient, and excellent stability. In terms of device operation, the electron transfer from the electron transporting layer to Sb2(S,Se)3 layer plays a critical role in improving the photovoltaic energy conversion efficiency of solar devices. Intricately manipulating the surface and interface properties has been a great challenge in solar cell fabrications. Herein, an effective approach toward the reconstruction of the CdS interfacial layer, and the following Sb2(S,Se)3 absorber film by utilizing polar ethylenediamine (EDA) solvent annealing at room temperature is developed. It is found that the presence of nitrogen‐containing functional groups of EDA on the CdS surface not only promotes the grain growth and crystallization of CdS, but also induces optimized deposition of Sb2(S,Se)3 films in terms of interfacial contact and defect formation. Finally, the Sb2(S,Se)3 solar cell based on EDA–CdS achieves a top efficiency of 10.10%. This study provides an efficient method and a new understanding of chemically healing inorganic thin films.
Surface Passivation with Diaminopropane Dihydroiodide for p‐i‐n Perovskite Solar Cells with Over 25% Efficiency
Authors: Lan Zhong‐Rui , Wang Yu‐Duan , Shao Jiang‐Yang , Ma Dian‐Xue , Liu Zhenghao , Li Dongmei , Hou Yi , Yao Jiannian , Zhong Yu‐Wu 
Published: December 2023

AbstractAt present, one of the major factors limiting the further improvement of inverted (p‐i‐n) perovskite solar cells (PSCs) is trap‐assisted non‐radiative recombination at the perovskite/electron transporting layer (ETL) interface. Surface passivation with organic ammonium salt is a powerful strategy to improve the performance of PSCs. Herein, an effective method by using propylamine hydroiodide (PAI) and 1,3‐diaminopropane dihydroiodide (PDADI) is reported to modify the perovskite/ETL interface. These two ammonium salts do not form new perovskite but directly passivate the defects on the perovskite surface after annealing. The results show that the PDADI‐modified perovskite films possess a lower surface defect density and less non‐radiative recombination as well as improved charge carrier transport. Based on this strategy, the PDADI‐modified p‐i‐n PSCs deliver an impressive efficiency of 25.09% (certified 24.58%) with an open‐circuit voltage of 1.184 V. Furthermore, the unencapsulated PDADI‐modified PSCs also exhibit good storage stability, retaining 91% of initial PCE at 65 °C in a N2 glove box for 1300 h. This strategy provides an efficient route to fabricate highly efficient and stable inverted p‐i‐n structured PSCs.
Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory Environment via Hypoxia‐Responsive Nanogels
Authors: Luo Wenhe , Zeng Yanqiao , Song Qingle , Wang Yu , Yuan Feng , Li Qi , Liu Yingnan , Li Su , Jannatun Nahar , Zhang Guofang , Li Yang 
Published: December 2023

AbstractDespite the success of immuno‐oncology in clinical settings, the therapeutic efficacy is lower than the expectation due to the immunosuppressive inflammatory tumor microenvironment (TME) and the lack of functional lymphocytes caused by exhaustion. To enhance the efficacy of immuno‐oncotherapy, a synergistic strategy should be used that can effectively improve the inflammatory TME and increase the tumor infiltration of cytotoxic T lymphocytes (CTLs). Herein, a TME hypoxia‐responsive nanogel (NG) is developed to enhance the delivery and penetration of diacerein and (‐)‐epigallocatechin gallate (EGCG) in tumors. After systemic administration, diacerein effectively improves the tumor immunosuppressive condition through a reduction of MDSCs and Tregs in TME, and induces tumor cell apoptosis via the inhibition of IL‐6/STAT3 signal pathway, realizing a strong antitumor effect. Additionally, EGCG can effectively inhibit the expression of PD‐L1, restoring the tumor‐killing function of CTLs. The infiltration of CTLs increases at the tumor site with activation of systemic immunity after the combination of TIM3 blockade therapy, ultimately resulting in a strong antitumor immune response. This study provides valuable insights for future research on eliciting effective antitumor immunity by suppressing adverse tumor inflammation. The feasible strategy proposed in this work may solve the urgent clinical concerns of the dissatisfactory checkpoint‐based immuno‐oncotherapy.
A Generic Strategy to Stabilize Wide Bandgap Perovskites for Efficient Tandem Solar Cells
Authors: Li Sheng , Zheng Zhuo , Ju Jiaqi , Cheng Siyang , Chen Feiyu , Xue Zexu , Ma Li , Wang Zhiping 
Published: December 2023

AbstractEfficient wide bandgap (WBG) perovskite solar cells (PSCs) are essential for fully maximizing the potential of tandem solar cells. However, these cells currently face challenges such as high photovoltage losses and the presence of phase segregation, which impede the attainment of their expected efficiency and stability. Herein, the root cause of halide segregation is investigated, uncovering a close association with the presence of locally aggregated lead iodide (PbI2), particularly at the perovskite/C60 interface. Kelvin‐probe atomic force microscopy results indicate that the remaining PbI2 at the interface leads to potential electrical differences between the domain surface and boundaries, which drives the formation of halide segregation. By reacting the surface PbI2 residue with ethanediamine dihydroiodide (EDAI2) at proper temperature, it is possible to effectively mitigate the phase segregation. By applying this surface reaction strategy in WBG inverted cells, a notable improvement of ≈100 mV is achieved in photovoltage over a wide range of WBG cells (1.67–1.78 eV), resulting in a champion efficiency of 23.1% (certified 22.95%) for 1.67 eV cells and 19.7% (certified 18.81%) for 1.75 eV cells. Furthermore, efficiency of 26.1% is demonstrated in a monolithic all‐perovskite tandem cell.
Maximizing Triboelectric Nanogenerators by Physics‐Informed AI Inverse Design
Authors: Jiao Pengcheng , Wang Zhong Lin , Alavi Amir H. 
Published: December 2023

AbstractTriboelectric nanogenerators offer an environmentally friendly approach to harvesting energy from mechanical excitations. This capability has made them widely sought‐after as an efficient, renewable, and sustainable energy source, with the potential to decrease reliance on traditional fossil fuels. However, developing triboelectric nanogenerators with specific output remains a challenge mainly due to the uncertainties associated with their complex designs for real‐life applications. Artificial intelligence‐enabled inverse design is a powerful tool to realize performance‐oriented triboelectric nanogenerators. This is an emerging scientific direction that can address the concerns about the design and optimization of triboelectric nanogenerators leading to a next generation nanogenerator systems. This perspective paper aims at reviewing the principal analysis of triboelectricity, summarizing the current challenges of designing and optimizing triboelectric nanogenerators, and highlighting the physics‐informed inverse design strategies to develop triboelectric nanogenerators. Strategic inverse design is particularly discussed in the contexts of expanding the four‐mode analytical models by physics‐informed artificial intelligence, discovering new conductive and dielectric materials, and optimizing contact interfaces. Various potential development levels of artificial intelligence‐enhanced triboelectric nanogenerators are delineated. Finally, the potential of physics‐informed artificial intelligence inverse design to propel triboelectric nanogenerators from prototypes to multifunctional intelligent systems for real‐life applications is discussed.
A “One Arrow Three Eagle” Strategy to Improve CM‐272 Primed Bladder Cancer Immunotherapy
Authors: Liu Ruiqi , Yang Jiani , Du Yaqian , Yu Xuefan , Liao Yuanyu , Wang Bojun , Yuan Kaikun , Wang Mingxu , Yao Yuanfei , Yang Piaoping 
Published: December 2023

AbstractImmunotherapy using an immune‐checkpoint blockade has significantly improved its therapeutic effects. CM‐272, which is a novel epigenetic inhibitor of G9a, induces immunogenic cell death (ICD) for recovering the sensitivity to anti‐PD‐1 antibodies; however, the efficacy of CM‐272 is greatly limited by promoting the transcription activity of HIF‐1α to form a hypoxic environment. Here, a Fe3+‐based nanoscale metal–organic framework (MIL‐53) is used to load CM‐272 (ultra‐high loading rate of 56.4%) for realizing an MIL‐53@CM‐272 nanoplatform. After entering bladder cancer cells, Fe3+ not only promotes the decomposition of H2O2 into O2 for O2‐compensated sonodynamic therapy but reduces the high level of glutathione in the tumor microenvironment (TME) for enhancing reactive oxygen species, including ferroptosis and apoptosis. MIL‐53 carriers can be degraded in response to the TME, accelerating the release of CM‐272, which helps achieve the maximum effectiveness in an O2‐sufficient TME by attenuating drug resistance. Furthermore, MIL‐53@CM‐272 enhances dendritic cell maturation and synergistically combines it with an anti‐programmed cell death protein 1 antibody during the study of immune‐related pathways in the transcriptomes of bladder cancer cells using RNA‐seq. This study presents the first instance of amalgamating nanomedicine with CM‐272, inducing apoptosis, ferroptosis, and ICD to achieve the “one arrow three eagle” effect.
Specific Propyne Trapping Sites within a Robust MOF for Efficient Propyne/Propadiene Separation with Record Propadiene Productivity
Authors: Jiang Yunjia , Wang Lingyao , Hu Jianbo , Krishna Rajamani , Chen Banglin , Zhang Yuanbin 
Published: December 2023

AbstractSeparating propyne/propadiene to produce pure propadiene is extremely challenging in industry due to their similar properties. Herein, a novel ZrF62− anion pillared cage‐like metal‐organic framework (termed as CuZrF6‐TPA) for highly efficient propyne/propadiene separation is reported. It exhibits high propyne capacity (177.4/188.6 cm3/cm3 at 0.5/1.0 bar and 298 K), benchmark separation selectivity (6.0), and remarkable separation potential (5.7 mol L−1) simultaneously. Record propadiene productivity (≈4.7 mol L−1) is achieved through a single adsorption process in breakthrough experiments with excellent recycle stability even under humid conditions. Based on the structure of propyne‐loaded single crystals, two binding sites are identified, including a major propyne trapping site at the windows and a minor binding site located in the large cages. Modelling studies further confirm that the contracted cage windows surrounded with rotating Lewis basic F atoms and aromatic rings are the optimal bonding sites to capture propyne with multiple hydrogen bonding and π···π interactions.
Tough Conductive Organohydrogel for Wearable Sensing in Extreme Environmental Conditions
Authors: Hong Seokkyoon , Park Taewoong , Lee Junsang , Ji Yuhyun , Dai Yumin , Yi Jonghun , Kim Joshua Jeremiah , Kim Dong Rip , Lee Chi Hwan 
Published: December 2023

AbstractConductive hydrogels, despite their significant potential, have faced historical limitations including vulnerability to dehydration, degradation of performance at extreme temperatures, and susceptibility to freezing in subzero conditions. Furthermore, the development of hydrogels that are both tough and stretchable, capable of maintaining performance under extreme environmental conditions, has remained a challenging task. Herein, an innovative conductive organohydrogel, distinguished by its superior toughness, stretchability, stability in regular ambient conditions, vacuum adaptability, and resistance to extreme temperatures is presented. By implementing a unique dry annealing process during synthesis, the mechanical strength of the organohydrogel has been substantially enhanced, dehydration concerns have been alleviated, and the structural integrity has been reinforced. In addition, the composition of the organohydrogel is specifically engineered to achieve both lasting endurance and sustainable longevity. This study signifies a crucial leap forward in creating high‐performing organohydrogels capable of functioning in a wide range of environments and conditions, thereby unlocking an array of adaptable applications.
Triplet Exciton Harvesting in Water by a Structurally Simple Organic Phosphor with Sustained Afterglow and Lifetime Tunability
Authors: Pattanayak Pradip , Nandi Arnab , Patra Ramen , Purkayastha Pradipta 
Published: December 2023

AbstractUltra‐long room temperature phosphorescence (URTP) materials are extremely promising for applications in organic electronics. Creating materials with controlled photophysics to achieve this, however, is difficult due to the challenges in filling up and stabilizing the sensitive triplet excited states at ambient temperature. Herein, triplet excitons are harvested by an intuitively designed structurally simple organic phosphor in water under ambient conditions by using supramolecular host–guest chemistry with cucurbituril‐7 (CB7) and sodium dodecyl sulphate (SDS), a negatively charged surfactant, with high photoluminescence (PL) quantum yields (PLQYs) (69% and 73% for CB7 and SDS, respectively) and phosphorescence lifetimes (12.52 and 12.42 ms for CB7 and SDS, respectively). A protective polyvinyl alcohol (PVA) film successfully controls the afterglow emission, excited state lifetime as well as PLQY in a single organic phosphor (CzPy24+). While a 1% concentration of CzPy24+ in the PVA film shows blue phosphorescence with 78.82% PLQY having a lifetime of 1.9 s, a 5% of CzPy24+ addition shows a green afterglow with 67.52% PLQY and a lifetime of 1.3 s. Similarly, yellow afterglow is achieved on adding 20% CzPy24+ to the PVA film with a PLQY of 40.88%. The findings are promising and helpful in constructing tunable phosphors for suitable applications.
Achieving Broadband NIR Emission in Fe3+‐Activated ALaBB′O6 (A = Ba, Sr, Ca; B–B′ = Li–Te, Mg–Sb) Phosphors via Multi‐Site Ionic Co‐Substitutions
Authors: Su Shikun , Hu Chen , Ding Shaolei , Sun Yutong , Sun Lijie , Zou Yanfei , Liu Ronghui , Lei Zonghao , Teng Bing , Zhong Degao 
Published: December 2023

Phosphor‐converted near‐infrared (NIR) LEDs are becoming increasingly demanded as miniature, portability, and broad emission spectrum. In this work, a class of Fe3+‐activated double perovskite structured is reported ALaBB′O6 (A = Ba, Sr, Ca; B–B′ = Li–Te, Mg–Sb) phosphors. Through the co‐substitution strategy at the A‐site and B‐B' sites, the emission spectral intensity and position of Fe3+ ions can be tuned. Finally, by utilizing Ca2+ at the A‐site and Mg–Sb co‐substitution for Li–Te, long‐wave NIR emission centered at 995 nm in CaLaMgSbO6: 0.6%Fe3+ with a full width at half maximum of 147 nm and internal quantum efficiency of 54.05% is achieved. The effects of the double perovskite crystal structure on Fe3+ photoluminescence properties are comprehensively analyzed. NIR LEDs are fabricated by encapsulating UV chips with the synthetic CaLaMgSbO6: 0.6%Fe3+ phosphors, and their application value in night vision, nondestructive biological monitoring, and NIR detection is evaluated.
Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease
Authors: Serrano Jean C. , Gillrie Mark R. , Li Ran , Ishamuddin Sarah H. , Moeendarbary Emad , Kamm Roger D. 
Published: December 2023

AbstractThe knowledge of the blood microvasculature and its functional role in health and disease has grown significantly attributable to decades of research and numerous advances in cell biology and tissue engineering; however, the lymphatics (the secondary vascular system) has not garnered similar attention, in part due to a lack of relevant in vitro models that mimic its pathophysiological functions. Here, a microfluidic‐based approach is adopted to achieve precise control over the biological transport of growth factors and interstitial flow that drive the in vivo growth of lymphatic capillaries (lymphangiogenesis). The engineered on‐chip lymphatics with in vivo‐like morphology exhibit tissue‐scale functionality with drainage rates of interstitial proteins and molecules comparable to in vivo standards. Computational and scaling analyses of the underlying transport phenomena elucidate the critical role of the three‐dimensional geometry and lymphatic endothelium in recapitulating physiological drainage. Finally, the engineered on‐chip lymphatics enabled studies of lymphatic‐immune interactions that revealed inflammation‐driven responses by the lymphatics to recruit immune cells via chemotactic signals similar to in vivo, pathological events. This on‐chip lymphatics platform permits the interrogation of various lymphatic biological functions, as well as screening of lymphatic‐based therapies such as interstitial absorption of protein therapeutics and lymphatic immunomodulation for cancer therapy.
Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre‐mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis
Authors: Nie Dan , Tang Xin , Deng Haijun , Yang Xiaojun , Tao Junji , Xu Fengli , Liu Yi , Wu Kang , Wang Kai , Mei Zhechuan , Huang Ailong , Tang Ni 
Published: December 2023

AbstractSolute carrier family 27 member 5, a key enzyme in fatty acid transport and bile acid metabolism in the liver, is frequently expressed in low quantities in patients with hepatocellular carcinoma, resulting in poor prognosis. However, it is unclear whether SLC27A5 plays non‐canonical functions and regulates HCC progression. Here, an unexpected non‐canonical role of SLC27A5 is reported: regulating the alternative splicing of mRNA to inhibit the metastasis of HCC independently of its metabolic enzyme activity. Mechanistically, SLC27A5 interacts with IGF2BP3 to prevent its translocation into the nucleus, thereby inhibiting its binding to target mRNA and modulating PIP4K2A pre‐mRNA splicing. Loss of SLC27A5 results in elevated levels of the PIP4K2A‐S isoform, thus positively regulating phosphoinositide 3‐kinase signaling via enhanced p85 stability in HCC. SLC27A5 restoration by AAV‐Slc27a5 or IGF2BP3 RNA decoy oligonucleotides exerts an inhibitory effect on HCC metastasis with reduced expression of the PIP4K2A‐S isoform. Therefore, PIP4K2A‐S may be a novel target for treating HCC with SLC27A5 deficiency.
Spontaneous Transition of Spherical Coacervate to Vesicle‐Like Compartment
Authors: Choi Hyunsuk , Hong Yuri , Najafi Saeed , Kim Sun Young , Shea Joan‐Emma , Hwang Dong Soo , Choi Yoo Seong 
Published: December 2023

AbstractNumerous biological systems contain vesicle‐like biomolecular compartments without membranes, which contribute to diverse functions including gene regulation, stress response, signaling, and skin barrier formation. Coacervation, as a form of liquid–liquid phase separation (LLPS), is recognized as a representative precursor to the formation and assembly of membrane‐less vesicle‐like structures, although their formation mechanism remains unclear. In this study, a coacervation‐driven membrane‐less vesicle‐like structure is constructed using two proteins, GG1234 (an anionic intrinsically disordered protein) and bhBMP‐2 (a bioengineered human bone morphogenetic protein 2). GG1234 formed both simple coacervates by itself and complex coacervates with the relatively cationic bhBMP‐2 under acidic conditions. Upon addition of dissolved bhBMP‐2 to the simple coacervates of GG1234, a phase transition from spherical simple coacervates to vesicular condensates occurred via the interactions between GG1234 and bhBMP‐2 on the surface of the highly viscoelastic GG1234 simple coacervates. Furthermore, the shell structure in the outer region of the GG1234/bhBMP‐2 vesicular condensates exhibited gel‐like properties, leading to the formation of multiphasic vesicle‐like compartments. A potential mechanism is proposed for the formation of the membrane‐less GG1234/bhBMP‐2 vesicle‐like compartments. This study provides a dynamic process underlying the formation of biomolecular multiphasic condensates, thereby enhancing the understanding of these biomolecular structures.
Endothelium‐Derived Engineered Extracellular Vesicles Protect the Pulmonary Endothelial Barrier in Acute Lung Injury
Authors: Gu Zhengyan , Sun Mingxue , Liu Jihao , Huang Qi , Wang Yunqin , Liao Jun , Shu Tingbin , Tao Min , Mao Guanchao , Pei Zhipeng , Meng Wenqi , Zhang Xinkang , Wei Youheng , Zhang Shanshan , Li Songling , Xiao Kai , Lu Ying , Xu Qingqiang 
Published: December 2023

AbstractAcute lung injury (ALI) is a severe respiratory disease with a high mortality rate. The integrity of the pulmonary endothelial barrier influences the development and prognosis of ALI. Therefore, it has become an important target for ALI treatment. Extracellular vesicles (EVs) are promising nanotherapeutic agents against ALI. Herein, endothelium‐derived engineered extracellular vesicles (eEVs) that deliver microRNA‐125b‐5p (miRNA‐125b) to lung tissues exerting a protective effect on endothelial barrier integrity are reported. eEVs that are modified with lung microvascular endothelial cell‐targeting peptides (LET) exhibit a prolonged retention time in lung tissues and targeted lung microvascular endothelial cells in vivo and in vitro. To improve the efficacy of the EVs, miRNA‐125b is loaded into EVs. Finally, LET‐EVs‐miRNA‐125b is constructed. The results show that compared to the EVs, miRNA‐125b, and EVs‐miRNA‐125b, LET‐EVs‐miRNA‐125b exhibit the most significant treatment efficacy in ALI. Moreover, LET‐EVs‐miRNA‐125b is found to have an important protective effect on endothelial barrier integrity by inhibiting cell apoptosis, promoting angiogenesis, and protecting intercellular junctions. Sequencing analysis reveals that LET‐EVs‐miRNA‐125b downregulates early growth response‐1 (EGR1) levels, which may be a potential mechanism of action. Taken together, these findings suggest that LET‐EVs‐miRNA‐125b can treat ALI by protecting the endothelial barrier integrity.
Simultaneously Intelligent Sensing and Beamforming Based on an Adaptive Information Metasurface
Authors: Jiang Rui Zhe , Ma Qian , Gu Ze , Liang Jing Cheng , Xiao Qiang , Cheng Qiang , Cui Tie Jun 
Published: December 2023

AbstractDue to its ability to adapt to a variety of electromagnetic (EM) environments, the sensing‐enabled metasurface has garnered significant attention. However, large‐scale EM‐field sensing to obtain more information is still very challenging. Here, an adaptive information metasurface is proposed to enable intelligent sensing and wave manipulating simultaneously or more specifically, to realize intelligent target localization and beam tracking adaptively. The metasurface is composed of an array of meta‐atoms, and each is loaded with two PIN diodes and a sensing‐channel structure, for polarization‐insensitive and programmable beamforming and sensing. By controlling the state of the PIN diode, the proposed meta‐atom has 1‐bit phase response in the designed frequency band, while the sensing loss keeps higher than ‐10 dB for both “ON” and “OFF” states. Hence there is nearly no interaction between the beamforming and sensing modes. Experiments are conducted to show multiple functions of the metasurface, including intelligent target sensing and self‐adaptive beamforming, and the measured results are in good agreement with the numerical simulations and theoretical calculations.