bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombosis after septal closure device placement: A review of the current literature
Authors: Sherman Jonathan M. , Hagler Donald J. , Cetta Frank 
Published: November 2004

AbstractThrombus formation has been described for all types of commercially available transcatheter septal occlusion devices. Most reports have been single‐institution case studies. Screening for hypercoagulable conditions prior to device placement and anticoagulation after device deployment has been variable. The objective of this study was to synthesize the current experience with device thrombosis; the Medline database from 1980 until 2004 was searched. Seventeen articles identified 54 unique patients with device thrombosis. Thrombus developed on eight different types of transcatheter devices. All commercially available devices had at least one reported case of thrombosis. Patient mean age was 44.2 ± 9.8 years. Thrombosis was diagnosed at a mean of 5 months after device deployment. Prior to device placement, 12 patients had normal coagulation evaluations and 5 had coagulopathies. For 37 patients, no mention was made in the report of coagulation studies. Prior to device thrombosis, 26 patients received aspirin and clopidrogel, 15 patients received aspirin alone, 8 received warfarin, 2 heparin alone, 1 aspirin and warfarin. One patient with hemophilia A received no anticoagulation and in one case treatment prior to thrombosis was not reported. After device thrombosis, 35 patients were treated with warfarin with thrombus resolution, 2 had successful lytic therapy, 1 was treated with heparin alone. Sixteen patients had surgical explantation of the device. Septal occlusion device thrombosis is rare. All types of commercially available devices have been associated with thrombosis. All patients should have early (≤ 3 months) echocardiographic surveillance for device thrombosis. Thorough coagulation evaluation is imperative prior to transcatheter device placement. Catheter Cardiovasc Interv 2004;63:486–489. © 2004 Wiley‐Liss, Inc.
SCAI statement on ad hoc versus the separate performance of diagnostic cardiac catheterization and coronary intervention
Authors: Blankenship James C. , Klein Lloyd W. , Laskey Warren K. , Krone Ronald J. , Dehmer Gregory J. , Chambers Charles , Cowley Michael 
Published: November 2004

AbstractCoronary intervention may be combined with diagnostic cardiac catheterization or performed separately. In the early years of angioplasty, performing these procedures separately was standard practice. Gradually, ad hoc intervention (performing diagnostic angiography and coronary intervention within the same session) has become more common, largely because of its convenience for patients and efficiency for physicians. However, the safety and potential cost savings of this approach remain uncertain. Criteria for the appropriate use of ad hoc intervention have not been established. Ad hoc intervention is reasonable for many, but not appropriate for all patients and should not be considered standard therapy. This document updates an earlier review of this topic and provides suggestions for the use of ad hoc intervention as a routine strategy. Catherter Cardiovasc Interv 2004;63:444–451. © 2004 Wilney‐Liss, Inc.
Implications of mediastinal uptake of 131I with regard to surgery in patients with differentiated thyroid carcinoma
Authors: Haveman Jan Willem , Phan Ha T. T. , Links Thera P. , Jager Piet L. , Plukker John T. M. 
Published: November 2004

AbstractBACKGROUNDFindings of mediastinal uptake of 131I after surgical treatment for differentiated thyroid carcinoma (DTC) are common, especially in young patients. Given the frequency of false‐positive findings, a protocol for diagnostic and therapeutic strategies would be useful. With the goal of accurately selecting management strategies, the authors analyzed their data and data found elsewhere in the literature for correlations with the incidence of mediastinal 131I uptake and with treatment for patients exhibiting such 131I uptake.METHODSAll patients with DTC who were treated between 1978 and 2000 at Groningen University Hospital (Groningen, The Netherlands) and who received adjuvant 131I ablation therapy were included in the current analysis, which involved retrospective review of all relevant data.RESULTSFive hundred four patients with DTC initially underwent total thyroidectomy, with additional 131I ablation performed for 489 of these patients. In 48 of 489 patients (9.8%), 131I uptake was seen in the mediastinum on a posttreatment scan. Analysis of those 48 patients and of cases in the literature demonstrated that serum thyroglobulin levels, risk status, and the presence of thymus on radiologic images were important in the surgical decision‐making process.CONCLUSIONSMediastinal uptake of 131I on posttreatment scans was found in approximately 10% of patients after total thyroidectomy for DTC. Based on the current data and the data presented in the literature, the authors developed a flow chart for determining appropriate treatment strategies, which included mediastinal dissection for high‐risk patients and for patients with serum thyroglobulin levels > 10 ng/mL. Cancer 2005. © 2004 American Cancer Society.
Thalidomide for advanced hepatocellular carcinoma
Authors: Wadler Scott 
Published: November 2004

According to recent reports, thalidomide is only marginally active in the treatment of hepatocellular carcinoma (HCC) and is relatively toxic for many debilitated patients. Thus, thalidomide's status as a viable alternative for the treatment of HCC is subject to debate.See also pages 85–91.
Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma
Authors: Lin Albert Y. , Brophy Nathalie , Fisher George A. , So Sam , Biggs Christopher , Yock Torunn I. , Levitt Lee 
Published: November 2004

AbstractBACKGROUNDThe hypervascular nature of hepatocellular carcinoma (HCC) is well characterized. Recent data have suggested that thalidomide possesses antiangiogenic and immunomodulatory activity. Therefore, the authors initiated a study to assess the efficacy and toxicity of thalidomide in patients with advanced HCC as primary and secondary endpoints, respectively.METHODSInclusion criteria were unresectable HCC with bidimentionally measurable disease, age ≥ 18 years, Eastern Cooperative Oncology Group performance status ≤ 2, and adequate organ function. Thalidomide was administered at a starting dose of 200 mg per day in a 100‐mg‐per‐week dose escalation regimen, up to the maximum tolerated dose or to 800 mg per day. Toxicity was monitored according to the National Cancer Institute Common Toxicity Criteria.RESULTSTwenty‐six of 27 patients were eligible and assessable for toxicity and response. A median daily dose of 300 mg was achieved. One patient experienced near‐complete recovery of α‐fetoprotein levels and a partial radiographic response on computed tomography. Two patients had stable disease during the 16‐week study period. The median duration of progression‐free survival was 42 days. The overall median survival was 123 days. Fatigue and somnolence were the most common side effects, occurring in 81% and 62% of patients, respectively. No Grade 4 hematologic toxicity was observed. Three patients experienced Grade 4 hepatic toxicity (namely, hyperbilirubinemia).CONCLUSIONSWith gradual dose escalation, thalidomide was tolerated in most patients with advanced HCC. However, treatment with thalidomide alone was associated with only a modest response in the treatment of HCC. Cancer 2005. © 2004 American Cancer Society.
A New Type of Supramolecular Assembly by Hydrogen Bond Templating: Identification of Rare Monodentate Acetate Coordination in [Fe3(µ3‐O)(µ2‐CH3COO)6(H2O)2(CH3COO)]·T·ClO4 (T = 2,6‐Diaminopyridinium Cation, C5H8N3 and 2‐Aminopyridinium Cation, C5H7N2)
Authors: Supriya Sabbani , Latha K. Swarna , Das Samar K. 
Published: November 2004

AbstractThe complexes [Fe3(µ3‐O)(µ2‐CH3COO)6(H2O)2(CH3COO)]· C5H8N3·ClO4 (C5H8N3 = 2,6‐diaminopyridinium cation) (1) and [Fe3(µ3‐O)(µ2‐CH3COO)6(H2O)2(CH3COO)]·C5H7N2· ClO4 (C5H7N2 = 2‐aminopyridinium cation) (2) show novel self‐assembled supramolecular structures in their crystals as elucidated by X‐ray analysis. The structures contain [Fe3(µ3‐O)(µ2‐CH3COO)6(H2O)2(CH3COO)] units as the building blocks. A detailed examination of the structures revealed that monodentate acetate, which is stabilised by a hydrogen‐bond template T (2,6‐diaminopyridinium cation in 1 and the 2‐aminopyridinium cation in 2), plays a directing role in forming these new types of hydrogen‐bonded assemblies in 1 and 2. Crystal data for 1 and 2 were determined by X‐ray structure analysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Oxidative Addition of Phenylselenyl Halides to Platinum(0) Complexes: Characterisation and Reactivity of the Products [PtX(SePh) (N,N‐chelate)(olefin)] (X = Cl, Br, I)
Authors: Albano Vincenzo G. , De Felice Vincenzo , Monari Magda , Roviello Giuseppina , Ruffo Francesco 
Published: November 2004

AbstractThe oxidative addition of PhSeX (X = Cl, Br, I) to Pt0 complexes of formula [Pt(N,N‐chelate)(olefin)] is described. The reaction quantitatively affords the trigonal‐bipyramidal products [PtX(SePh)(N,N‐chelate)(olefin)] with the X and SePh fragments in the axial positions. NMR spectroscopic data have allowed us to gain insights into the geometrical isomerism of some of these complexes. The reactivity of the axial ligands towards electrophilic reagents is also investigated, and the molecular structures of [PtX(SePh)(dmphen)(dimethyl fumarate)] (X = Br, I) are compared. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Hybrid Magnetic Materials Based on Nitroxide Free Radicals and Extended Oxalato‐Bridged Bimetallic Networks
Authors: Alberola Antonio , Coronado Eugenio , Giménez‐Saiz Carlos , Gómez‐García Carlos J. , Romero Francisco M. , Tarazón Ana 
Published: November 2004

AbstractA series of hybrid organic‐inorganic magnets of formula p‐rad[MIICr(ox)3] [M = Mn (1), Co (2), Ni (3), Zn (4)] and m‐rad[MIICr(ox)3] [M = Mn (5), Co (6)], in which N‐methylpyridinium cations bearing a nitronyl nitroxide moiety in positions 3 (m‐rad) or 4 (p‐rad) of the pyridine ring coexist with the 2D honeycomb‐like oxalato‐bridged bimetallic lattice, has been prepared and studied by AC and DC magnetic susceptibility measurements and EPR spectroscopy. In general, the physical properties of these magnets are not altered significantly by the insertion of the nitronyl nitroxide radicals although these paramagnetic molecules seem to interact weakly with the inorganic network as demonstrated by EPR spectroscopy. Some differences can also be observed between the p‐rad and m‐rad series, i.e. m‐rad derivatives have smaller values for the critical temperatures and coercive fields. We also report on the X‐ray crystal structures and magnetic properties of p‐rad[Mn(H2O)Cr(ox)3]·2H2O (7) and m‐rad[Mn(H2O)2Cr(ox)3]·2H2O (8), two extended oxalato‐bridged compounds with new topologies. Compound 7 is antiferromagnetic and its structure is a 3D achiral lattice in which zigzag ferromagnetic MnCr chains (J/k = +0.8 K) are interconnected to form hellicoidal hexagonal channels with the cationic free radicals residing in the free space. Compound 8, however, exhibits a ladder‐like structural pattern with competing magnetic interactions and paramagnetic behaviour down to low temperatures. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Electrophilic Bromination of N‐Acylated Cyclohex‐3‐en‐1‐amines: Synthesis of 7‐Azanorbornanes
Authors: Kapferer Peter , Vasella Andrea 
Published: November 2004

AbstractThe intramolecular bromo‐amidation and the dibromination‐cyclisation of the N‐acylcyclohex‐3‐en‐1‐amines 4, 8, 9, 11, 13, 14, and 16 was studied in view of the synthesis of bicyclic amines that are of interest as building blocks and potential glycosidase inhibitors. The trifluoroacetamides 4, 9, and 14 reacted with N‐bromosuccinimide (NBS) in AcOH to give dihydro‐1,3‐oxazines in good yields. The stereoselectivity of the dibromination of the alkenes 8 and 9 depends on the nature of the protecting group, the reagent, and the reaction conditions. Br2 in CH2Cl2 transformed the alkenes 8 and 9 predominantly into diaxial trans,trans‐dibromides. Bromination of 9 with PhMe3NBr3 or with Br2 in the presence of Et4NBr gave predominantly the diequatorial trans,cis‐27 besides some trans,trans‐28. A similar bromination of the C(5)‐substituted N‐acyl‐4‐aminocyclohexenes 11, 13, 14, and 16 with PhMe3NBr3 was accompanied by intramolecular side reactions that were suppressed by the addition of excess Et4NBr. Under these conditions, 11 gave diastereoselectively trans‐dibromides, while its reaction with Br2 gave trans‐dibromides along with the dihydrooxazinone 31. Also the carbamate 13 reacted with PhMe3NBr3/Et4NBr selectively to the trans‐dibromide 32 and with Br2 to the trans‐dibromides 32 and 33, the dihydrooxazinone 34, and the bicyclic ether 35. Similarly, the trifluoroacetamide 14 provided the dibromide 36 (89%), while its reaction with Br2 led to the dihydrooxazine 22, and the dibromides 36 and 37. The N‐benzyl‐N‐Boc derivative 16 did not yield any dibromide; it reacted with PhMe3NBr3/Et4NBr to the dihydrooxazinone 38, and with Br2 to the oxazinone 38 and the bicyclic ether 39. The high stereoselectivity of the bromination with PhMe3NBr3/Et4NBr suggests an anchimeric assistance of the NHR substituent. Deprotection, cyclisation, and carbamoylation transformed the dibromides 27, 29, and 32 into the 7‐azanorbornanes 42, 49, and 53. The diols 45 and 57 were obtained from 42 and 53 via HBr elimination and stereoselective dihydroxylation; they proved weak inhibitors of several glycosidases. In no case could the formation of a bicyclic azetidine (6‐azabicyclo[3.1.1]heptane) from the dibromides 26 and 30 be observed.
Nonnucleosidic Base Surrogates: The Effect of 1,2‐Disubstituted Phenanthrenes on DNA Duplex Stability
Authors: Ackermann Damian , Häner Robert 
Published: November 2004

AbstractPhenanthrene‐1,2‐dimethanol was incorporated into oligodeoxynucleotides via formation of phosphodiester bonds (cf. Scheme 1). If placed at internal positions in a DNA duplex, a strong reduction of duplex stability is observed (Table 1). Terminal attachment of stretches of phenanthrene residues, however, leads to a substantial increase in stability. The stabilization is attributed to a cooperative interaction of the phenanthrene residues of the two strands rather than to dangling end effects. Chimeric oligomers containing a stretch of six phenanthrene residues show two separate transitions (Table 2): one arising from the denaturation of the DNA stem (observable by a hyperchromic effect at 260 nm) and a second one from the denaturation of the phenanthrene part (observable by temperature‐dependant gel mobility assays). Based on these findings, a model of the chimeric hybrids is proposed, in which the phenanthrene residues stack in a zipper‐like manner on top of the DNA base pairs without disrupting the B‐form of the DNA stem (see Fig. 7).
Efficient Solid Phase Synthesis of Cleavable Oligodeoxynucleotides Based on a Novel Strategy for the Synthesis of 5′‐S‐(4,4′‐Dimethoxytrityl)‐2′‐deoxy‐5′‐thionucleoside Phosphoramidites
Authors: Jahn‐Hofmann Kerstin , Engels Joachim W. 
Published: November 2004

AbstractThe incorporation of a specific cleavage site into an oligodeoxynucleotide can be achieved by utilizing the four 5′‐S‐(4,4′‐dimethoxytrityl)‐2′‐deoxy‐5′‐thionucleoside 3′‐(2‐cyanoethyl diisopropylphosphoramidites) 5 and 15a–c (Fig. 1). Based on the silver ion assisted cleavage of PS and CS bonds, we synthesized oligodeoxynucleotides with an achiral 5′‐phosphorothioate linkage 3′–O–P–S–5′ by the solid‐phase phosphoramidite procedure. The efficient cleavage of these modified oligodeoxynucleotides can be detected by HPLC, PAGE, and surface plasmon resonance (SPR) spectrometry. The liberated 5′‐thiol moiety can be used directly for post‐reaction labeling with appropriately functionalized reporter groups.
Novel Bleomycin Analogues: Synthesis, Antitumor Activity, and Interaction with DNA
Authors: Xu Zhi‐Dong , Wang Min , Xiao Su‐Long , Zhang Yan‐Juan , Yang Ming 
Published: November 2004

AbstractThe novel analogues 11–16 of bleomycin A6 (3) were obtained by selective protection of the primary‐amine function of the β‐aminoalaninamide moiety of 3 by means of coordination with CuII ions, condensation with an aliphatic or aromatic acid R′COOH in the presence of dicyclohexylcarbodiimide, and demetalization (Scheme). The antitumor activity against HeLa and BGC‐823 in vitro, binding property with CT‐DNA, and cleavage potency towards pBR322 DNA were also studied (Tables 1–3). All the compounds 11–16 displayed significant antitumor activity, which was enhanced as the hydrophobicity of the C‐terminus substituent R′ increased, but decreased as the DNA‐binding affinity increased. There was a negative relationship between DNA‐cleavage potency and binding affinity to DNA in this series of compounds.
Rubriflorin A and B, Two Novel Partially Saturated Dibenzocyclooctene Lignans from Schisandra rubriflora
Authors: Li Liang , Ren Hai‐Ying , Yang Xiao‐Dong , Zhao Jing‐Feng , Li Gan‐Peng , Zhang Hong‐Bin 
Published: November 2004

AbstractFrom the stems of Schisandra rubriflora, two novel partially saturated dibenzocyclooctene lignans, named rubriflorin A (1) and B (6), as well as the seven known partially saturated dibenzocyclooctene lignans kadsumarin A (2), kadsurin (3), heteroclitin B (4), heteroclitin C (5), heteroclitin D (7), interiorin (8), and interiorin B (9) were isolated. The structures of the new compounds 1 and 6 were established on the basis of spectral analysis as (5R,6S,7R,8R,13aS)‐8‐(acetyloxy)‐5,6,7,8‐tetrahydro‐1,2,3,13‐tetramethoxy‐6,7‐dimethylbenz([3,4]cycloocta[1,2‐f][1,3]benzodioxol‐5‐yl (2Z)‐2‐methylbut‐2‐enoate and (6R,7R,12aS)‐7,8‐dihydro‐12‐hydroxy‐1,2,3,10,11‐pentamethoxy‐6,7‐dimethyl‐6H‐dibenzo[a,c]cycloocten‐5‐one, respectively.
Medical errors: The perspective of the insurer
Authors: James Thomas 
Published: November 2004

AbstractErrors in medicine have a significant impact upon the cost of health insurance in the United States. These errors may reflect a range of errors ranging from ineffective or futile care to inappropriate medical judgments to coding errors. These may be unintentional, but underlying all of these error‐types is a failure of process stemming back to physician training. The commercial industries that pay for health insurance may be demanding a process approach and accountability structures in return for continued funding of health care services. J. Surg. Oncol. 2004;88:195–199. © 2004 Wiley‐Liss, Inc.
Is the chronologic age a contra‐indication for surgical palliation of unresectable periampullary neoplasms?
Authors: Nuzzo G. , Clemente G. , Greco F. , Ionta R. , Cadeddu F. 
Published: November 2004

AbstractMethodsEarly and late results of surgical palliation for unresectable periampullary neoplasms were evaluated in 24 patients older than 70 years and compared with the same results obtained from 33 younger patients. The two groups of patients were comparable, except for age. Biliary bypass associated to gastric bypass was the most common performed procedure.ResultsNo significant differences in the results (morbidity, mortality, and outcome) were found in the two groups of patients. In addition, the results of palliative surgery in the elderly were compared with those obtained from a comparable group of 35 patients palliated with endoscopic stent insertion: surgical palliation resulted in better long‐term results.ConclusionsThis study provides evidence that the chronologic age is not a contra‐indication for surgical palliation of periampullary neoplasms and that surgery provides a better quality of residual life. J. Surg. Oncol. 2004;88:206–209. © 2004 Wiley‐Liss, Inc.
Neuropeptide Y alters stress‐induced changes in trace element concentrations of brain in chronically immobilized rats
Authors: Karakoc Yunus , Turhan Sibel , Yildirim Ejder Akgun , Mengi Murat , Yurdakos Ertan , Barutcu U. Bora 
Published: November 2004

AbstractCentral administration of neuropeptide Y (NPY) produces anxiolytic‐like behavioral responses in the conflict test, elevated plus maze, fear‐potentiated startle paradigm, and in the chronic immobilization stress. Exogenously administrated NPY also protects against the anxiogenic effects of corticotropin‐releasing factor. In the present study, we aimed to determine the effects of centrally administered NPY on the trace element disturbances in brain tissues (frontal and temporal lobes and brain stem) and the other major organs including liver, spleen (zinc [Zn]‐, copper [Cu]‐, and iron‐rich tissues), kidney, and stomach in chronically immobilized rats. The immobilization stress was performed in special cages in which the animals were not able to move. The rats in chronic stress and chronic stress + NPY groups were kept in the cages daily for 7 min for 15 consecutive days. Intracerebroventricular (ICV) cannulas were placed to the right lateral ventricles of the rats by using stereotaxic method. In the control and chronic stress groups, 5 μL of saline (NaCl 0.9%), and in the chronic stress + NPY group, 8 μg NPY/5 μL saline solutions, were administered into the brain via ICV cannula, respectively. Controls and immobilized rats were decapitated 30 min after the injections were over and samples of tissue were taken. Zn, Cu, and iron levels of the frontal lobe, temporal lobe, brain stem, liver, spleen, kidney, and stomach were determined by flame atomic absorption spectrophotometer. Zn and Cu levels were significantly increased in the frontal lobe, temporal lobe, and brain stem in response to chronic immobilization stress daily for 7 min for 15 consecutive days. The administration of NPY inhibited the elevation of Zn in these three parts of brain but did not affect the elevation of Cu in the frontal lobe and brain stem. Increases in Zn and Cu levels of frontal, temporal lobes, and brain stem may be related to induction of MT‐I mRNA expression by chronic immobilization stress, and NPY may affect this induction of MT‐I, altering corticotropin‐releasing factor release in the stress conditions. J. Trace Elem. Exp. Med. 17:283–290, 2004. © 2004 Wiley‐Liss, Inc.
Parameter Estimation of the Disk in a Floating Caliper Disk Brake Model with respect to Squeal
Authors: Jearsiripongkul Thira , Hagedorn Peter 
Published: November 2004

AbstractNoise from a vehicle is always a concern for any automotive industry looking for passenger comfort. This also holds for the different types of brake noise, in particular for squeal, which is a source of discomfort both to passengers and passers‐by. Intensive research on low frequency squeal (noise between 1‐5 kHz) has been carried out. A model of the floating caliper disk brake has been recently proposed by the authors with the aim to predict the onset of squeal. A flutter type instability resulting from nonconservative restoring forces is assumed to be the reason behind squeal in this model. The problem of validating the model against experimental observation lies in the fact that all the system parameters included in the model, especially the disk, are to be carefully chosen. In this work some parameters of the disk are estimated and a method is suggested to estimate these parameters in a systematic way. For that purpose, the values are to be accurately selected by experiments and modal updating technique. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)