bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the bearing characteristics of overrun hydraulic support under impact loading
Authors: Cao Lianmin , Yan Ping , Xi Wenxian , Zhang Xiaowei , Jin Xin , Yang Hongjuan 
Published: December 2023

In order to study the effects of stress change and adaptability of the overrun hydraulic stent under impact load, the rigid–flexible coupling numerical model of the stent is established using multi-body dynamics simulation software ADAMS. In the model, the stent is flexibilized using the HyperMesh module, and the column and jack are equivalently replaced with a spring damping system. By applying impact loads to different positions above the front roof beam of the stent, the dynamic response characteristics of the column and the articulation point are obtained at different positions with different strengths. The results show that when the impact load is applied to different positions of the front roof beam, the steady-state response force of the column shows an overall “M" distribution, and along the length direction of the roof beam, the steady-state response force of the column shows an upward trend, and the maximum steady-state response force of the column is 547 kN at point (1, 6); when the impact load is applied to both sides of the front roof beam, the response at the articulation point is greater, resulting in a higher maximum simple harmonic response at that articulation point. When the impact load acts on both sides of the front roof beam, the response of the articulation point is greater, with a maximum simple harmonic response coefficient of 0.75 and a maximum excitation response coefficient of 0.28; when the impact loads of different strengths act on the whole front roof beam, the force acting on the column and pin shaft at the articulation point will produce a large impact, reducing its adaptability. To address this, we can consider changing the top plate stress conditions using methods like high-pressure injection of water and control the gradual and slow release of the top plate stresses. The results of the study provide a reference for the structural strength design and reliability analysis of the hydraulic support, which is of practical significance and value for improving the safe mining of the coal mining face.
The evolution of glacial lake and glaciers and their potential impact on glacial debris flow activity in the Palong Zangbu catchment in Southeastern Tibet
Authors: Yang Liu , Chuan Tang , Lingfeng Gong , Jiang Xiong 
Published: December 2023

Due to warm and humid air currents of the Indian Ocean and the southwest monsoon, the Palong Zangbo catchment in southeastern Tibet has developed oceanic glaciers in the valley, and the activity of glacial debris flows has been gradually intensified under neotectonic activity, frequent earthquakes, climate change, and extreme rainfall. In this paper, the topographic and morphological data of the debris flow basin, the dynamic evolution characteristics of glaciers and glacial lakes were analyzed by using multisource long-term series of remote sensing images. Simultaneously, the distribution of moraines and landslide sources were extracted based on satellite image. In addition, climate change in the study area was analysed using temperature and rainfall data from the last 40 years, revealing that the average temperature in the study area from May to October presented a fluctuating tendency as a whole, especially after 2013, when the temperature gradually increased. As these temperature changes led to continuous melting of the glaciers in the study area, the glacier area decreased from 8,300 km2 in 1988–4,584 km2 in 2019, which decreased nearly 45%. However, the number and area of glacial lakes in the study area gradually increased under a power-law trend, which further led to a significant increase on the possibility of glacial lake rupture in the study area. Due to the joint effects of earthquakes, glacier melting and glacial lake collapse, the debris flows in the study area were well developed, and a total of 122 debris flows were found with varying channel lengths, areas and material sources. Importantly, the characteristics of the glaciers, glacial lakes and climate change in the study area have indicated that the glaciers have retreated, the number of glacial lakes has increased, and the risk of debris flow in this basin will increase in the future. Therefore, it is necessary to strengthen monitoring and early warnings on floods due to glacial lake collapses and debris flows in the study area to improve the risk management of debris flows and floods and the prevention and mitigation of disasters.
A rapid dual-drive technology for extinguishing large high-gas coal mines fires
Authors: Mei Yong 
Published: December 2023

Fires formed by the high gas protrusion in coal mines are difficult and risky to extinguish during the mine closure process due to the mine’s large closed range and underground gas stock. To achieve efficient and safe unsealing, reduce the risk of re-ignition and gas explosion, and accurately determine the fire extinguishing effect, a dual-drive rapid fire extinguishing technology is proposed. This technology involves ground precise positioning of drilling holes, rapid and large flow of liquid nitrogen injection, and curtain grouting to block fires in ultra-large high-gas mines. The practical results demonstrate that the implementation of surface injection of liquid nitrogen for fire extinguishing and cooling, and plugging effectively reduces the concentration of CO in the underground space from 230 PPm to 0 PPm, and decreases the CH4 concentration content from 90% to less than 0.75%. The fire extinguishing and cooling effect is fast and significant. A technical scheme for unsealing the fire area of the whole mine is formulated on a large scale based on the state of pumping and releasing pressure in the closed space of the mine. This scheme has important guiding significance for safety rescue and rescue operations after serious fire accidents occur in similar high-gas prominent mines.
Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model
Authors: Iorgulescu J. Bryan , Ruthen Neil , Ahn Ryuhjin , Panagioti Eleni , Gokhale Prafulla C. , Neagu Martha , Speranza Maria C. , Eschle Benjamin K. , Soroko Kara M. , Piranlioglu Raziye , Datta Meenal , Krishnan Shanmugarajan , Yates Kathleen B. , Baker Gregory J. , Jain Rakesh K. , Suvà Mario L. , Neuberg Donna , White Forest M. , Chiocca E. Antonio , Freeman Gordon J. , Sharpe Arlene H. , Wu Catherine J. , Reardon David A. 
Published: December 2023

BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intrinsic mechanisms that drive immunotherapy resistance in CT2A-luc and to define the aspects of human cancer biology that these lines can best model, we systematically compared their characteristics using whole exome and transcriptome sequencing, and protein analysis through immunohistochemistry, Western blot, flow cytometry, immunopeptidomics, and phosphopeptidomics.ResultsThe transcriptional profiles of GL261-luc2 and CT2A-luc tumors resembled those of some huGBMs, despite neither line sharing the essential genetic or histologic features of huGBM. Both models exhibited striking hypermutation, with clonal hotspot mutations in RAS genes (Kras p.G12C in GL261-luc2 and Nras p.Q61L in CT2A-luc). CT2A-luc distinctly displayed mesenchymal differentiation, upregulated angiogenesis, and multiple defects in antigen presentation machinery (e.g. Tap1 p.Y488C and Psmb8 p.A275P mutations) and interferon response pathways (e.g. copy number losses of loci including IFN genes and reduced phosphorylation of JAK/STAT pathway members). The defect in MHC class I expression could be overcome in CT2A-luc by interferon-γ treatment, which may underlie the modest efficacy of some immunotherapy combinations. Additionally, CT2A-luc demonstrated substantial baseline secretion of the CCL-2, CCL-5, and CCL-22 chemokines, which play important roles as myeloid chemoattractants.ConclusionAlthough the clinical contexts that can be modeled by GL261 and CT2A for huGBM are limited, CT2A may be an informative model of immunotherapy resistance due to its deficits in antigen presentation machinery and interferon response pathways.
The diagnostic accuracy of carbon monoxide pulse oximetry in adults with suspected acute carbon monoxide poisoning: a systematic review and meta-analysis
Authors: Ramponi Giacomo , Gianni Francesca , Karlafti Eleni , Piazza Isabelle , Albertoni Francesco , Colombo Giorgio , Casazza Giovanni , Garegnani Anna , Casella Rosa , Costantino Giorgio 
Published: December 2023

IntroductionAcute carbon monoxide poisoning (COP) is one of the leading causes of intoxication among patients presenting to the emergency department (ED). COP symptoms are not always specific and may vary from mild to critical. In the last few years, COHb pulse oximeters have been developed and applied to the setting of suspected COP. The aim of this systematic review is to assess the diagnostic accuracy of CO pulse oximetry (SpCO) with carboxyhemoglobin (COHb) levels measured by blood gas analysis, used as a reference standard, in patients with suspected COP.MethodsWe developed our search strategy according to the PICOS framework, population, index/intervention, comparison, outcome, and study, considering the diagnostic accuracy of SpCO compared to COHb levels measured by blood gas analysis, used as a reference standard, in patients with suspected COP enrolled in cross-sectional studies in English. The search was performed on MEDLINE/PubMed and EMBASE in February 2022. Quality assessment was performed using the QUADAS-2 methodology. A COHb cutoff of 10% was chosen to test the sensitivity and specificity of the index test. A bivariate model was used to perform the meta-analysis. The protocol was registered on PROSPERO (CRD42022359144).ResultsA total of six studies (1734 patients) were included. The pooled sensitivity of the test was 0.65 (95% CI 0.44–0.81), and the pooled specificity was 0.93 (95% CI 0.83–0.98). The pooled LR+ was 9.4 (95% CI 4.4 to 20.1), and the pooled LR- was 0.38 (95% CI 0.24 to 0.62).ConclusionOur results show that SpCO cannot be used as a screening tool for COP in the ED due to its low sensitivity. Because of its high LR+, it would be interesting to evaluate, if SpCO could have a role in the prehospital setting as a tool to quickly identify COP patients and prioritize their transport to specialized hospitals on larger samples with a prospective design.
Headache-related clinical features in teleworkers and their association with coping strategies during the COVID-19 pandemic
Authors: Houle Mariève , Ducas Julien , Lardon Arnaud , Descarreaux Martin , Marchand Andrée-Anne , Abboud Jacques 
Published: December 2023

ObjectivesThe objectives were (1) to describe and compare headache-related clinical features between teleworkers with migraine and those with tension-type headache (TTH) and (2) to determine the association between coping strategies and headache frequency, and intensity in the context of the COVID-19 pandemic.MethodsThis cross-sectional online survey was conducted with 284 teleworkers (127 with migraine and 157 with TTH). Sociodemographic data, information related to work factors, headache clinical features, coping strategies used during the COVID-19 pandemic, and headache-related clinical features were compared between headache profiles. Bivariate logistic regression analyses were used to determine the association between coping strategies and headache frequency, and intensity.ResultsResults showed that teleworkers with migraine had longer and more painful headache episodes than teleworkers with TTH (ps &lt; 0.001). Higher migraine frequency was associated with the use of the denial coping strategy (p = 0.006) while lower migraine intensity was associated with planning (p = 0.046) and the use of positive reframing (p = 0.025). Higher TTH frequency was associated with the use of venting, self-blame, and behavioral disengagement (ps &lt; 0.007) while higher TTH intensity was associated with substance use and behavioral disengagement (ps &lt; 0.030). All associations remained significant after adjusting for BMI as a covariate.Discussion/conclusionTeleworkers with migraine had more intense and longer headache episodes than teleworkers with TTH. This could be explained by the fact that a greater proportion of individuals suffering from migraine experienced headaches prior to the beginning of the pandemic compared with teleworkers suffering from TTH. Regarding coping strategies, both primary headache profiles were associated with different types of coping strategies. Most of the coping strategies associated with headache frequency or intensity were maladaptive except for planning and positive reframing that were found to be inversely associated with migraine intensity.
Aplicación del NaHCO3 como estrategia fisicoquímica para mitigar el impacto ambiental de la vinaza producida en la destilación de alcohol artesanal
Authors: Morales Avendaño Ever Darío , Navarrete Álava Jhonny , Garzón Cedeño Francesco , Zambrano Lara Marvin 
Published: December 2023

La vinaza es un subproducto derivado de la destilación del fermentado del guarapo de caña de azúcar y caracterizado por elevados niveles de CE, DQO, DBO5 y acidez; lo cual ocasiona un impacto ambiental en los sectores de producción. El objetivo del presente estudio consistió en determinar el efecto del HNaCO3 como tratamiento fisicoquímico para mitigar la actividad herbicida de la vinaza colectada en una unidad productora artesanal de alcohol. Muestras de 10L a pH 4,0 fueron distribuidas en envases y ajustadas a pH de 5, 6 y 7 con HNaCO3; luego analizadas en cuanto a la CE, DQO, DBO5, salinidad y temperatura. El experimento se realizó con 10 especies de plantas silvestres, mantenidas en envases de 6,5 y 3,5L. Todas las unidades experimentales fueron dosificadas con vinaza a pH 4 (control), 5, 6 y 7, cada tres días, según su capacidad volumétrica (100 o 150ml); durante 8 semanas. Los resultados reflejaron un descenso de la CE hasta un 98%, y una tendencia a la reducción de DQO con el incremento del pH. En cambio, el NaHCO3 no influyo en la DBO5; sin embargo, el porcentaje de remoción de la CE y DQO, produjo una reducción del efecto herbicida; mientras que en solo tres especies se observó efecto a nivel foliar, entre 5 y 30%. Se considera que el NaHCO3 promueve la reducción de la DQO, CE y neutraliza la acidez; lo cual sugiere la factibilidad de aplicación en suelos, contribuyendo así con la mitigación del impacto ambiental.
Palabras clave: Bioherbicida, Biofertilizante, DBO5, DQO, Licor, pH.
The Rancang Bangun Prototipe Sistem Otomatis Bangunan Pintar Pada Rumah Kos Bertingkat
Authors: Darmawan Muhammad Diky 
Published: December 2023

Abstrak - Kenyamanan dalam suatu ruangan mampu memberikan relaksasi bagi tubuh yang penat dari kegiatan sehari hari oleh dari itu menggunakan teknologi Smart Building Automatis Sistem yang juga bisa disebut sebuah bangunan cerdas adalah sebuah desain dari kontruksi dan proteksi teknologi yang cocok digunakan untuk mengeluarkan semuah fungsionalitas dan kenyamanan bagi penghuni dengan tujuan juga untuk mengurangi biaya operasional, dan memperpanjang umur bentuk dari fisik. Untuk komponen yang akan diapakai ada keterkaitan hubungan melalui jaringan lokal yang sudah disediakan, sehingga bisa difungsikan untuk berbagai macam hal, salah satunya digunakan untuk memantau dan memonitoring pengendalian pencahayaan pada sebuah bangunan komersial. Pada penelitian ini akan membangun sebuah sistem menggunakan Esp-32 yang digunakan sebagai mikrokontroler, lalu untuk memantau suhu dan kelembapan akan memakai sensor Dht-11 yang digunakan mengendalikan sistem Blower otomatis, dan juga menggunakan modul sensor LDR yang kegunaannya sebagai pengontrol lampu secara otomatis serta manual, dan semua hasil ini akan ditampilkan di dashboard Node Red yang menjadi pusat monitoring. Karena bisa dibilang pencahayaan ialah sebuah sumber energi terbesar yang dipakai oleh manusia, dengan demikian berakibat pada melunjaknya biaya operasional yang harus dikeluarkan, terlebih jika penggunaan energi tersebut tidak terkontrol dengan baik.

Kata kunci : Smart Building Automatis Sistem, Esp 32, Node Red, Dht 11, Modul Sensor LDR
Investimentos públicos em educação superior na Bahia: o orçamento das Universidades Estaduais Baianas / Public investments in higher education in Bahia: the budget of Baian State Universities
Authors: Silva Marta Rosa Farias de Almeida Miranda 
Published: December 2023

O artigo objetiva apresentar estudo sobre o financiamento da educação superiorpública na Bahia evidenciando a Educação no contexto dos Orçamentos do Estadono período de 2014 a2017. Sob esta perspectiva, o tema insere-se na Temática Políticas Públicas para a Educação Superior. Evidencia dados acerca da alocação dos recursos públicos diretos destinados aos orçamentos das Universidades Estaduais Baianas (UEBAs). Para esse fim, fizemosuma revisão dos aspectos relativos aos orçamentos públicos em educação, levantamos e analisamos os dados sobre a evolução dos créditos consignados à Função Educação e às UEBAs, apresentando resultados preliminares de estudos exploratórios, bibliográficos e documentais.Os dados demonstram um cenário de grandes desafios para as Instituições Estaduais Públicas de Educação Superior da Bahia, não apenas no que se refere ao repensar ou redefinir o modelo de financiamento, a ampliação do percentual da receita, os critérios que determinam a participação proporcional do orçamento entre as UEBAs ou ainda,a subsidiar a política pública em Educação Superior na Bahia, mas,principalmente, de evidenciar qual o efetivo grau de prioridade do governo para a Educação Superior ofertada pelas Universidades Publicas Estaduais.
Peranan Pemimpin Gereja Bagi Jemaat Dalam Menjaga Keutuhan NKRI Dari Ancaman Radikalisme
Authors: Harita Novi Saria , Setiawan David Eko 
Published: December 2023

Abstract: Radicalism is an understanding or practice of a doctrine that is considered true and is also an extreme idea. This kind of understanding can be a threat to the sustainability of the nation, religion, ethnicity and race in Indonesia. This understanding arises because the values ​​of Pancasila are no longer implemented in the life of the nation and state. So what is the role of church leaders in maintaining the integrity of the Republic of Indonesia from the threat of radicalism in the lives of their congregations? To answer these questions, in this study the author uses a descriptive qualitative approach with the library method. The purpose of this study is to explain the role of a church leader in maintaining the integrity of the Unitary State of the Republic of Indonesia from the threat of radicalism to the congregation he leads. The results of this study are church leaders must provide guidance to local church members, encourage congregations to care for each other through deacon services and encourage congregations to be involved in the nationalism movement.
Abstrak: Radikalisme adalah paham atau pengamalan suatu doktrin yang dianggap benar dan juga merupakan gagasan yang ekstrim. Pemahaman seperti ini dapat menjadi ancaman bagi keberlangsungan bangsa, agama, suku dan ras di Indonesia. Pemahaman ini muncul karena nilai-nilai Pancasila tidak lagi diimplementasikan dalam kehidupan berbangsa dan bernegara. Lantas bagaimana peran pimpinan gereja dalam menjaga keutuhan NKRI dari ancaman radikalisme dalam kehidupan jemaatnya? Untuk menjawab pertanyaan tersebut, dalam penelitian ini penulis menggunakan metode kepustakaan. Tujuan dari penelitian ini adalah untuk menjelaskan peran seorang pemimpin gereja dalam menjaga keutuhan Negara Kesatuan Republik Indonesia dari ancaman radikalisme kepada jemaat yang dipimpinnya. Hasil dari penelitian ini adalah pemimpin gereja harus melakukan pembinaan terhadap warga gereja lokal, mendorong jemaat untuk saling peduli melalui pelayanan diakonia dan mendorong jemaat untuk terlibat dalam pergerakan nasionalisme.
ІСТОРИЧНИЙ НАРИС СТАНОВЛЕННЯ ВЗАЄМОДІЇ ОРГАНІВ ПУБЛІЧНОЇ ВЛАДИ В СИСТЕМІ НАЦІОНАЛЬНОЇ БЕЗПЕКИ НА ТЕРИТОРІЇ СУЧАСНОЇ УКРАЇНИ
Authors: Ісайко Денис 
Published: December 2023

У статті проаналізовано історичні особливості становлення взаємодії органів публічної влади в системі національної безпеки на території сучасної України. Сформоване авторське розуміння етапності цього процесу та визначено його п’ять послідовних та взаємопов’язаних складових: середньовічний етап (з початку української державності до кінця ХVIII ст.), імперський етап (з кінця ХVIII ст. до початку ХХ ст.), етап української революції (1917-1921 роки), радянський етап (1921-1991 роки) та етап незалежності (з 1991 року по сьогодення).
Аргументовано, що на середньовічному етапі не виникло певних умов, які б сприяли концептуальному вираженню та оформленню національної безпеки як сфери публічного управління. Разом з тим, окрема діяльність органів публічної влади та погляди тогочасних управлінців на проблематику у досліджуваній сфері, стали основною для становлення взаємодії на подальших етапах. З’ясовано, що під час імперського етапу вперше сформувались та почали активно діяти органи публічної влади, до повноважень яких відносилось вчинення дій, спрямованих на захист державного ладу, суверенітету та територіальної цілісності. При цьому, останні, попри відсутність прямих управлінських та нормативних засад, взаємодіяли між собою шляхом обміну інформацією, значимою для національної безпеки. Визначено, що етап української революції ознаменувався формуванням думки про необхідність забезпечення національної безпеки самостійної Української Держави для захисту національних інтересів українського суспільства. Крім того, сформовано низку профільних органів публічної влади, які стали прототипом для сучасних спецслужб, насамперед української армії, безпекових та розвідувальних органів, які взаємодіяли між собою для відбиття зовнішньої загрози. Також, закцентовано увагу на тому, що під час радянського етапу сформовано цілісну систему органів публічної влади у сфері забезпечення національної безпеки, які взаємодіяли між собою у різних формах під впливом реформ та глобальних подій світової політичної обстановки, а також створено нормативні умови для здійснення спільної діяльності.
Наголошено, що існуючий історичний досвід став основою для побудови системи забезпечення національної безпеки під час етап незалежності та вказав на необхідність взаємодії профільних органів публічної влади, особливо в період війни з Російською Федерацією.