bluuebunny/crossref_metadata_2025_split huggingface dataset:
The De Bruijn Graph Sequence Mapping Problem with Changes in the Graph
Authors: Rocha Lucas B. , Adi Said Sadique , Araujo Eloi 
Published: February 2024

AbstractIn computational biology, mapping a sequencesonto a sequence graphGposes a significant challenge. One possible approach to tackling this problem is to find a walkpinGthat spells a sequence most similar tos. This challenge is formally known as the Graph Sequence Mapping Problem (GSMP). In this paper, we delve into an alternative problem formulation known as the De Bruijn Graph Sequence Mapping Problem (BSMP). Both problems have three variants: changes only in the sequence, changes in the graph, and changes in both the sequence and the graph. We concentrate on addressing the variant involving changes in the graph. In the literature, when this problem does not allow the De Bruijn graph to induce new arcs after changes, it becomes NP-complete, as proven by Gibneyet. al[4]. However, we reformulate the problem by considering the characteristics of the arcs induced in the De Bruijn graph. This reformulation alters the problem definition, thereby enabling the application of a polynomial-time algorithm for its resolution. Approaching the problem with this arc-inducing characteristic is new, and the algorithm proposed in this work is new in the literature.
Adeno-associated viruses for efficient gene expression in the axolotl nervous system
Authors: Lust Katharina , Tanaka Elly M. 
Published: February 2024

SummaryAxolotls are models for studying nervous system evolution, development, and regeneration. Tools to visualize and manipulate cells of the axolotl nervous system with high efficiency, spatial and temporal precision are therefore greatly required. Recombinant adeno-associated viruses (AAVs) are frequently used forin vivogene transfer of the nervous system but virus-mediated gene delivery to the axolotl nervous system has not yet been described. Here, we demonstrate the use of AAVs for efficient gene transfer within the axolotl brain and the retina. We show that serotypes AAV8, AAV9, AAVRG and AAVPHP.eB are suitable viral vectors to infect both excitatory and inhibitory neuronal populations of the axolotl brain. We further use AAV9 to trace retrograde and anterograde projections between the retina and the brain and identify a cell population projecting from the brain to the retina. Together, our work establishes AAVs as a powerful tool to interrogate neuronal organization in the axolotl.
Dispersal and gene flow in anadromous salmonids: a systematic review
Authors: Lamarins Amaïa , Carlson Stephanie M. , Buoro Mathieu 
Published: February 2024

AbstractDispersal is a ubiquitous ecological process that has been extensively studied in many plants and animals. Anadromous salmonids are an interesting system for examining dispersal, in part because of their well-known philopatric behavior, but also because of the conservation challenges related to the dispersal of hatchery-origin fish. Building on earlier work, we provide an updated systematic review of dispersal and gene flow in anadromous salmonids. In particular, we compared studies on dispersal of anadromous salmonids from wild and hatchery origins, including studies providing estimates of dispersal rates, observations of dispersal, and results from modelling studies. We reviewed 228 studies and found these were unevenly distributed among species, with Atlantic salmon, Chinook salmon, and sea trout being well-represented. Our results showcase considerable variability in estimated dispersal rates within and across studies, which is likely related to the different methodologies, dispersal propensities across species and populations, and spatial extents considered. Overall, our results confirmed a higher tendency of hatchery fish to disperse relative to wild fish, but we also found some variation across species that warrants further study. Moreover, we found that dispersal propensity tended to decline exponentially with distance, and that the drivers of dispersal varied considerably among studies. Additionally, we highlight various facets of dispersal captured across this suite of studies, including variation in terminology, methods and metrics for characterizing dispersal, and the spatio-temporal scales considered. Finally, our review revealed that few studies considered, and even fewer assessed, the implications of dispersal for the conservation and management of anadromous salmonids.
Supplier selection for carbon emission reduction collaboration in green supply chain using an improved multi-criteria decision-making method
Authors: Wang Qing , Zhang Xiaoli , Su Jiafu , Zhang Na 
Published: February 2024

PurposePlatform-based enterprises, as micro-entities in the platform economy, have the potential to effectively promote the low-carbon development of both supply and demand sides in the supply chain. Therefore, this paper aims to provide a multi-criteria decision-making method in a probabilistic hesitant fuzzy environment to assist platform-type companies in selecting cooperative suppliers for carbon reduction in green supply chains.Design/methodology/approachThis paper combines the advantages of probabilistic hesitant fuzzy sets (PHFS) to address uncertainty issues and proposes an improved multi-criteria decision-making method called PHFS-DNMEREC-MABAC for aiding platform-based enterprises in selecting carbon emission reduction collaboration suppliers in green supply chains. Within this decision-making method, we enhance the standardization process of both the DNMEREC and MABAC methods by directly standardizing probabilistic hesitant fuzzy elements. Additionally, a probability splitting algorithm is introduced to handle probabilistic hesitant fuzzy elements of varying lengths, mitigating information bias that traditional approaches tend to introduce when adding values based on risk preferences.FindingsIn this paper, we apply the proposed method to a case study involving the selection of carbon emission reduction collaboration suppliers for Tmall Mart and compare it with the latest existing decision-making methods. The results demonstrate the applicability of the proposed method and the effectiveness of the introduced probability splitting algorithm in avoiding information bias.Originality/valueFirstly, this paper proposes a new multi-criteria decision making method for aiding platform-based enterprises in selecting carbon emission reduction collaboration suppliers in green supply chains. Secondly, in this method, we provided a new standard method to process probability hesitant fuzzy decision making information. Finally, the probability splitting algorithm was introduced to avoid information bias in the process of dealing with inconsistent lengths of probabilistic hesitant fuzzy elements.
Homocysteine potentiates amyloid β‐induced death receptor 4‐ and 5‐mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment
Authors: Carey Ashley , Parodi‐Rullan Rebecca , Vazquez‐Torres Rafael , Canepa Elisa , Fossati Silvia 
Published: February 2024

AbstractCerebrovascular dysfunction has been implicated as a major contributor to Alzheimer's Disease (AD) pathology, with cerebral endothelial cell (cEC) stress promoting ischemia, cerebral‐blood flow impairments and blood–brain barrier (BBB) permeability. Recent evidence suggests that cardiovascular (CV)/cerebrovascular risk factors, including hyperhomocysteinemia (Hhcy), exacerbate AD pathology and risk. Yet, the underlying molecular mechanisms for this interaction remain unclear. Our lab has demonstrated that amyloid beta 40 (Aβ40) species, and particularly Aβ40‐E22Q (AβQ22; vasculotropic Dutch mutant), promote death receptor 4 and 5 (DR4/DR5)‐mediated apoptosis in human cECs, barrier permeability, and angiogenic impairment. Previous studies show that Hhcy also induces EC dysfunction, but it remains unknown whether Aβ and homocysteine function through common molecular mechanisms. We tested the hypotheses that Hhcy exacerbates Aβ‐induced cEC DR4/5‐mediated apoptosis, barrier dysfunction, and angiogenesis defects. This study was the first to demonstrate that Hhcy specifically potentiates AβQ22‐mediated activation of the DR4/5‐mediated extrinsic apoptotic pathway in cECs, including DR4/5 expression, caspase 8/9/3 activation, cytochrome‐c release and DNA fragmentation. Additionally, we revealed that Hhcy intensifies the deregulation of the same cEC junction proteins mediated by Aβ, precipitating BBB permeability. Furthermore, Hhcy and AβQ22, impairing VEGF‐A/VEGFR2 signaling and VEGFR2 endosomal trafficking, additively decrease cEC angiogenic capabilities. Overall, these results show that the presence of the CV risk factor Hhcy exacerbates Aβ‐induced cEC apoptosis, barrier dysfunction, and angiogenic impairment. This study reveals specific mechanisms through which amyloidosis and Hhcy jointly operate to produce brain EC dysfunction and death, highlighting new potential molecular targets against vascular pathology in comorbid AD/CAA and Hhcy conditions.
Effects of temperature on the survival of spotted lanternfly active life stages when held without food
Authors: Keena Melody A. 
Published: February 2024

Abstract
Spotted lanternfly, Lycorma delicatula White (Hemiptera: Fulgoridae), is an invasive Southeast Asian planthopper that was recently introduced into the eastern United States and spreads along human transportation corridors by ‘hitch‐hiking’ on vehicles and cargo.
To better understand the risk of establishment when mobile life stages are moved, it is critical to know how long spotted lanternfly mobile life stages will survive without food and water under different temperatures.
This work reports on spotted lanternfly first, second, and third instar nymphal and adult survival without food over the 10–30°C temperature range. Survival time without food declined exponentially as temperature increased for all life stages of spotted lanternfly that were evaluated.
At temperatures <30°C, first instar nymphs survived longer than second or third instar individuals. Female adults survived about 1 day longer than male adults at all but 10 and 25°C.
Without food, 99% of all adults of both sexes are predicted to be dead in less than a week over the temperature range evaluated. First instars, which were the smallest, survived the longest and their survival exponentially decreased as temperature increased.
This suggests that more attention to first instar movement may be warranted. The data presented here will provide a basis for assessing the risk of survival of transported spotted lanternfly active life stages along various pathways.
Not all faultlines are created equal: The heterogeneous impact of TMT faultlines on a firm's ESG disclosure
Authors: Pan Chao , Su Xin , Zhong Xi 
Published: February 2024

AbstractDriven by the theory of sustainable development, Chinese firms have gradually realized the importance of ESG disclosure. Executives play a core role in ESG decision‐making, but whether and how top management team (TMT) faultlines affect ESG disclosure has yet to be systematically discussed. Based on the attention‐based view and faultline theory, we select 6456 observations of 910 Chinese A‐share listed firms from 2012 to 2021 as the research object to empirically test the above critical practical issues that have not been fully answered. We find that TMT information‐based faultlines improve firms' ESG disclosure, but TMT social category faultlines reduce firms' ESG disclosure. In addition, the internal mechanism test showed that the TMT's future‐oriented attention plays a mediating role in the above relationship. Finally, we also find that institutional shareholding enhances the positive impact of the TMT's future‐oriented attention on ESG disclosure. This study enriches the literature on TMT faultlines and ESG disclosure, demonstrating that the composition of the TMT and its attention allocation are important factors for promoting firms' ESG disclosure. The conclusions of this study can help firms strengthen their ESG disclosure by building efficient TMTs and provide important implications for firms to better fulfill their ESG responsibilities.
No‐reflow after stroke reperfusion therapy: An emerging phenomenon to be explored
Authors: Jia Milan , Jin Feiyang , Li Sijie , Ren Changhong , Ruchi Mangal , Ding Yuchuan , Zhao Wenbo , Ji Xunming 
Published: February 2024

AbstractIn the field of stroke thrombectomy, ineffective clinical and angiographic reperfusion after successful recanalization has drawn attention. Partial or complete microcirculatory reperfusion failure after the achievement of full patency of a former obstructed large vessel, known as the “no‐reflow phenomenon” or “microvascular obstruction,” was first reported in the 1960s and was later detected in both experimental models and patients with stroke. The no‐reflow phenomenon (NRP) was reported to result from intraluminal occlusions formed by blood components and extraluminal constriction exerted by the surrounding structures of the vessel wall. More recently, an emerging number of clinical studies have estimated the prevalence of the NRP in stroke patients following reperfusion therapy, ranging from 3.3% to 63% depending on its evaluation methods or study population. Studies also demonstrated its detrimental effects on infarction progress and neurological outcomes. In this review, we discuss the research advances, underlying pathogenesis, diagnostic techniques, and management approaches concerning the no‐reflow phenomenon in the stroke population to provide a comprehensive understanding of this phenomenon and offer references for future investigations.
Ostomy continence devices: a systematic review of the literature and meta‐analysis
Authors: Dourado Justin , Garoufalia Zoe , Emile Sameh Hany , Wignakumar Anjelli , Aeschbacher Pauline , Rogers Peter , Delgado Zachary , Greer Matthew , Wexner Steven D. 
Published: February 2024

AbstractAimColostomy complication rates range widely from 10% to 70%. The psychological burden on patients, leading to lifestyle changes and decreased quality of life (QoL), is one of the largest factors. The aim of this work was to assess the history and efficacy of ostomy continence devices in improving continence and QoL.MethodIn this PRISMA‐compliant systematic review and meta‐analysis, we searched PubMed, Scopus, Google Scholar and clinicaltrials.gov for studies on continence devices for all ostomies up to April 2023. Primary outcomes were continence and improvement in QoL. Secondary outcomes were leakage, patient's device preference and complications. Risk of Bias 2 and the revised tool to assess risk of bias in non‐randomized studies of interventions (ROBINS‐1) were used to assess risk of bias. Certainty of evidence was graded using GRADE.ResultsTwenty‐two studies assessed devices from 1978 to 2022. The two main types identified were ball‐valve devices and plug systems. Conseal and Vitala were the two main devices with significant evidence allowing for pooled analyses. Conseal, the only currently marketed device, had a pooled rate of continence of 67.4%, QoL improvement was 74.9%, patient preference over a traditional appliance was 69.1%, leakage was 10.1% and complications was 13.7%. Since 2011, five studies have investigated experimental devices on both human and animal models.ConclusionOstomy continence has been a long‐standing goal without a consistently reliable solution. We propose that selective and short‐term usage of continence devices may lead to improved continence and QoL in ostomy patients. Further research is needed to develop a reliable daily device for ostomy continence. Future investigation should include the needs of ileostomates.
Immediate and long‐term management practices of acute symptomatic seizures and epileptiform abnormalities: A cross‐sectional international survey
Authors: Punia Vineet , Daruvala Sanaya , Dhakar Monica B. , Zafar Sahar F. , Rubinos Clio , Ayub Neishay , Hirsch Lawrence J. , Sivaraju Adithya ,   for Post‐Acute Symptomatic Seizure Investigation and Outcomes Network (PASSION) investigators
Published: February 2024

AbstractObjectivesAcute symptomatic seizures (ASyS) and epileptiform abnormalities (EAs) on electroencephalography (EEG) are commonly encountered following acute brain injury. Their immediate and long‐term management remains poorly investigated. We conducted an international survey to understand their current management.MethodsThe cross‐sectional web‐based survey of 21 fixed‐response questions was based on a common clinical encounter: convulsive or suspected ASyS following an acute brain injury. Respondents selected the option that best matched their real‐world practice. Respondents completing the survey were compared with those who accessed but did not complete it.ResultsA total of 783 individuals (44 countries) accessed the survey; 502 completed it. Almost everyone used anti‐seizure medications (ASMs) for secondary prophylaxis after convulsive or electrographic ASyS (95.4% and 97.2%, respectively). ASM dose escalation after convulsive ASyS depends on continuous EEG (cEEG) findings: most often increased after electrographic seizures (78% of respondents), followed by lateralized periodic discharges (LPDs; 41%) and sporadic epileptiform discharges (sEDs; 17.5%). If cEEG is unrevealing, one in five respondents discontinue ASMs after a week. In the absence of convulsive and electrographic ASyS, a large proportion of respondents start ASMs due to LPD (66.7%) and sED (44%) on cEEG. At hospital discharge, most respondents (85%) continue ASM without dose change. The recommended duration of outpatient ASM use is as follows: 1–3 months (36%), 3–6 months (30%), 6–12 months (13%), >12 months (11%). Nearly one‐third of respondents utilized ancillary testing before outpatient ASM taper, most commonly (79%) a <2 h EEG. Approximately half of respondents had driving restrictions recommended for 6 months after discharge.SignificanceASM use for secondary prophylaxis after convulsive and electrographic ASyS is a universal practice and is continued upon discharge. Outpatient care, particularly the ASM duration, varies significantly. Wide practice heterogeneity in managing acute EAs reflects uncertainty about their significance and management. These results highlight the need for a structured outpatient follow‐up and optimized care pathway for patients with ASyS.
Herbage accumulation, nutritive value, and fatty acid profile of bermudagrass cultivars grown in different latitudes
Authors: Bretas Igor L. , Naumann Harley D. , Dubeux Jose C. B. , Vendramini Joao M. B. , Silva Hiran M. S. , Rios Esteban , Queiroz Luana M. D. , Mawhinney Thomas P. 
Published: February 2024

AbstractThe geographical distribution of bermudagrass cultivars is limited by freezing events (<0°C), commonly associated with higher latitudes in the northern hemisphere. The lipid composition in the plant cell membranes is critical to promote persistence under freezing conditions. This study evaluated herbage accumulation (HA), nutritive value, and lipid biosynthesis of different bermudagrass cultivars in Ona, FL (27°26' N 82°55' W) and Marianna, FL (30o52' N 85o11' W), in 2 years. Treatments were five bermudagrass cultivars (Coastal, Tifton 44, Tifton 85, Jiggs, and Mislevy) distributed in a randomized complete block design with four replicates. HA was greater in Marianna than in Ona for all cultivars (p < 0.05). Mislevy and Jiggs had greater HA in Marianna than the others (p < 0.05), while all cultivars were similar in Ona (p > 0.05). There was no difference between locations or among the cultivars for crude protein and neutral detergent fibre, but bermudagrass cultivars had greater in vitro digestibility of organic matter (IVDOM) in Marianna than in Ona (p < 0.05). The concentration of unsaturated fatty acids increased in the northern latitude (Marianna; p < 0.05). Coastal had greater unsaturated fatty acid concentration than other cultivars (p < 0.05). Geographical location affects HA, IVDOM, and unsaturated fatty acid concentration of bermudagrass cultivars. The unsaturated fatty acid concentration plays a key role in acclimating bermudagrass to different thermal environments. Coastal showed great potential to tolerate chilling stress in Florida. Further studies may be developed to identify promising molecular markers for cold tolerance in bermudagrass.
Bark‐beetle disturbance severity only moderately alters forest affinity of arthropod communities
Authors: Kortmann Mareike , Buse Jörn , Hilszczański Jacek , Jaworski Tomasz , Müller Jörg , Thorn Simon , Roth Nicolas 
Published: February 2024

Abstract
Forest ecosystems are facing increasing challenges like natural disturbances. Despite positive disturbance impacts on the diversity of several taxonomic groups, there are still concerns, whether the drastic canopy opening can lead to a turnover from forest to open habitat species.
We sampled arthropods along a disturbance gradient in Norway spruce (Picea abies)‐dominated protected areas across Central Europe using Malaise traps and metabarcoding.
To analyse changes in arthropod communities in terms of forest affinities along the disturbance gradient, we explored the potential of a list of forest affinities (LFA) that provides information about species affinities from closed forest to open habitats.
Our results show that the mean forest affinity decreased with increasing disturbance severity. This trend was accompanied by a decrease in forest‐associated species as well as community shifts for open and mixed habitat species. Responses varied between taxa and were most apparent in Coleoptera.
Overall, the changes did not come with a complete replacement of forest specialists by species with higher affinities for mixed and open landscapes nor a drastic loss of forest species. Furthermore, we observed severely disturbed plots with a high mean forest affinity and vice versa, which calls for further studies using these kinds of species classifications.
The LFA can provide additional information how species associated with forests habitats can react to environmental changes beyond increasing amounts of deadwood resources. Using additional trapping methods and determination techniques might increase the explanatory power of such analyses along ecological gradients.
What can we learn about skin of color in dermatopathology?
Authors: Wondimu Bitania , Sokumbi Olayemi 
Published: February 2024

AbstractAs the US population becomes increasingly diverse, more patients of color seek dermatologic care and often have concerns that are unique to their skin color. Therefore, it is critically important that the knowledge gap in skin of color dermatology be urgently addressed. In addition to addressing the clinical gap in recognizing dermatologic disease in patients of color, the role of dermatopathology in bridging this gap remains unaddressed. Given the impact that skin color can have on the presentation and subsequent management of dermatologic diseases, understanding the current knowledge of the unique structural and histologic characteristics in skin of color may help give us insight on the role skin color should play in histopathologic diagnosis. In this paper, we bring insights into the role dermatopathology plays in addressing our knowledge of cutaneous disease in patients with skin of color. After we highlight issues to consider, we can begin to identify gaps in knowledge that still exist within dermatopathology that need to be addressed to ensure patients of all backgrounds receive equitable dermatologic care.