bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Retrospective Study of the Association between Respiratory Tract Viral PCR Panel Results and Clinical Outcomes in Children with Cancer and Febrile Neutropenia and Review of the Literature
Authors: Terzi Özlem , Karabulut Nuran , Uysalol Ezgi Paslı , Kaçar Ayşe Gonca , Solgun Hüseyin Avni , Ertürk Saide , Şimşek Halil İbrahim , Bayram Cengiz , Ayçiçek Ali 
Published: October 2023

Abstract
Objective The role of respiratory viral pathogens (RVPs) in children with cancer having febrile neutropenic (FEN) episodes has not been well studied. The objectives of this study were to investigate the prevalence and clinical outcomes of RVP in this group.
Methods Pediatric patients with cancer and an episode of FEN, presenting between March 2021 and March 2022 were included. All data were retrospectively retrieved from patient files. A throat swab sample was obtained for the detection of 17 RVPs and evaluated by a polymerase chain reaction (PCR) method.
Results A total of 110 (male n = 76; 69.1%) patients with a mean ± standard deviation age of 6.68 ± 4.92 years were included. Reproduction in PCR was seen in 76 (69.1%) children. Rhinovirus (31.6%) and respiratory syncytial virus (15.8%) were the most frequently detected viruses. Mixed respiratory viruses (coinfections of ≥2 viruses) were only seen in 13%. The median (range) duration of hospitalization was 11 (2–143) days, and 8.2% of the children were admitted to the pediatric intensive care unit (PICU). The median (range) length of stay (LOS) in the PICU was 8 (1–100) days. Overall mortality rate was 3.6%. There was no significant difference in LOS in the hospital, rate of admission to PICU, LOS in the PICU, and the mortality rate between children with and without growth in PCR (p > 0.05).
Conclusion There was high prevalence of RVP in children with cancer and FEN. However, given that having a positive RVP does not affect LOS in the hospital/PICU or disease severity, in this population, there was no association between positive PCR findings and clinical features investigated or outcome.
“Lid Switch Flap” for Subtotal Upper Eyelid Reconstruction: Where the Flap Pedicle and the Point of Rotation Should be Located
Authors: Karonidis Athanasios , Tsallas Stefanos , Louros Liberis 
Published: October 2023

AbstractWe report our experience using the “lid switch flap” for the reconstruction of large upper eyelid defects, emphasizing on the design, the point of flap rotation, and the detailed description of the surgical technique. From 2018 to 2021, three patients with squamous cell carcinoma (SCC) invading 50 to 70% of the upper eyelid underwent tumor excision. The defects were reconstructed using the two-stage “lid switch flap” method. At the first stage, the “switch flap” from the lower eyelid was designed medially based preferably, elevated and “switched” to the defect, whereas the pedicle was divided at the second stage in 2 to 3 weeks. The mean of defect widths after tumor excision (D) was 23.6 mm (range: 18–29 mm) and the mean of widths of lid switch flaps (F) was 15.3 mm (range: 10–20 mm), and thus, the mean of F/D ratio was 0.63 (range: 0.55–0.69). The histopathology report confirmed the complete excision of the SCCs. The patients were followed up for 2 years. The functional and aesthetic results were excellent.
Level of Evidence Level II, therapeutic study.
A New Method of Matrix-Based Triage for Nuclear Disasters
Authors: Kumar Pramod , Gupta Apoorva 
Published: October 2023

AbstractDuring nuclear disaster, infrastructure is severely damaged and injuries are often combined with trauma/burns and whole-body radiation. This makes triage difficult, especially when resources are severely deficient. To solve this problem, in this article, the authors have suggested a new less technology-dependent radiation dosimetry and quick triage using a specially designed triage matrix during nuclear disasters.
Prognostic Relevance of the Lung Ultrasound Score: A Multioutcome Study in Infants with Respiratory Distress Syndrome
Authors: Szymański Piotr , Puskarz-Gąsowska Joanna , Hożejowski Roman , Stefańska Małgorzata , Błaż Witold , Sadowska-Krawczenko Iwona , Majewska Urszula , Tomaszkiewicz Anna , Piotrowska Małgorzata , Kusibab-Mytych Marta , Słowik-Wasyluk Natalia , Kruczek Piotr , Bokiniec Renata 
Published: October 2023

Objective There is growing evidence for the usefulness of the lung ultrasound score (LUS) in neonatal intensive care. We evaluated whether the LUS is predictive of outcomes in infants with respiratory distress syndrome (RDS).
Study Design Neonates less than 34 weeks of gestational age were eligible for this prospective, multicenter cohort study. The outcomes of interest were the need for mechanical ventilation (MV) at <72 hours of life, the need for surfactant (SF), successful weaning from continuous positive airway pressure (CPAP), extubation readiness, and bronchopulmonary dysplasia. Lung scans were taken at 0 to 6 hours of life (Day 1), on Days 2, 3, and 7, and before CPAP withdrawal or extubation. Sonograms were scored (range 0–16) by a blinded expert sonographer. The area under the receiver operating characteristic curve (AUC) was used to estimate the prediction accuracy of the LUS.
Results A total of 647 scans were obtained from 155 newborns with a median gestational age of 32 weeks. On Day 1, a cutoff LUS of 6 had a sensitivity (Se) of 88% and a specificity (Sp) of 79% to predict the need for SF (AUC = 0.86), while a cutoff LUS of 7 predicted the need for MV at <72 hours of life (Se = 89%, Sp = 65%, AUC = 0.80). LUS acquired prior to weaning off CPAP was an excellent predictor of successful CPAP withdrawal, with a cutoff level of 1 (Se = 67%, Sp = 100%, AUC = 0.86).
Conclusion The LUS has significant predictive ability for important outcomes in neonatal RDS.
Key Points
Prevalence and Risk Factors for Tube-Feeding at Discharge in Infants following Early Congenital Heart Disease Surgery: A Single-Center Cohort Study
Authors: Viswanathan Sreekanth , F. Ong Kaitlyn Jade , Kakavand Bahram 
Published: October 2023

Objective Oral feeding difficulty is common in infants after congenital heart disease (CHD) surgical repair and is associated with prolonged hospital stay and increased risk for tube-feeding at discharge (TF). The current understanding of the enteropathogenesis of oral feeding difficulty in infants requiring CHD surgery is limited. To determine the prevalence and risk factors for TF following CHD surgery in early infancy.
Study Design This was a 6-year single-center retrospective cohort study (2016–2021) of infants under 6 months who had CHD surgery. Infants required TF were compared with infants who reached independent oral feeding (IOF).
Results Of the final sample of 128 infants, 24 (18.8%) infants required TF at discharge. The risk factors for TF in univariate analysis include low birth weight, low 5-minute Apgar score, admitted at birth, risk adjustment in congenital heart surgery categories IV to VI, presence of genetic diagnosis, use of Prostin, higher pre- and postsurgery respiratory support, lower weight at surgery, lower presurgery oral feeding, higher presurgery milk calory, delayed postsurgery enteral and oral feeding, higher pre- and postsurgery gastroesophageal reflux disease (GERD), need for swallow study, abnormal brain magnetic resonance imaging (p < 0.05). In the multivariate analysis, only admitted at birth, higher presurgery milk calories, and GERD were significant risk factors for TF. TF had significantly longer hospital stay (72 vs. 17 days) and lower weight gain at discharge (z-score: −3.59 vs. −1.94) compared with IOF (p < 0.05).
Conclusion The prevalence of TF at discharge in our study is comparable to previous studies. Infants with CHD admitted at birth, received higher presurgery milk calories, and clinical GERD are significant risk factors for TF. Mitigating the effects of identified risk factors for TF will have significant impact on the quality of life for these infants and their families and may reduce health care cost.
Key Points
Drug-Induced Hypoglycemia in Neonates Born to Nondiabetic Women Treated with Medications during the Pregnancy or the Labor: A Systematic Review of the Literature
Authors: Maines Evelina , Cardellini Maria Chiara , Stringari Giovanna , Leonardi Letizia , Piccoli Giovanni , Urru Silvana Anna Maria , Maiorana Arianna , Soffiati Massimo , Franceschi Roberto 
Published: October 2023

The prompt identification of at-risk newborns for drug-induced hypoglycemia can minimize the risk for adverse side effects, inappropriate investigations, and considerable unnecessary costs. Existing literature discusses drug-induced hypoglycemia, but a systematic description of neonatal hypoglycemia induced or exacerbated by maternal medications is missing. We reviewed the association between neonatal hypoglycemia and maternal medications. We systematically searched the literature according to the PICOS model on drug-induced hypoglycemia in neonates born to nondiabetic women treated with medications during the pregnancy or the labor. The main outcomes of the review were: (1) prevalence of hypoglycemia, (2) risk factors and potential confounders, (3) time at onset and severity of hypoglycemia, (4) dose–response gradient, (5) metabolic features of hypoglycemia, (6) modalities to treat hypoglycemia, and (7) quality of the studies. We included 69 studies in this review and we identified 11 groups of maternal drugs related to neonatal hypoglycemia. Results were classified for each outcome. Our review aims at supporting clinicians in the identification of the newborn at risk for hypoglycemia and in the differential diagnosis of neonatal hypoglycemia. Further studies are necessary to assess the risk of neonatal hypoglycemia associated with common maternal medications.
Key Points
Difficulties in Pregnancy Adjustment as Predictors of Perinatal Depression: Indirect Effects through the Role of Brooding Rumination and Maternal–Fetal Bonding
Authors: Vega-Sanz Maria , Rey-Sáez Ricardo , Berástegui Ana , Sánchez-López Álvaro 
Published: October 2023

Abstract
Objective The aim of this research was to study the ways in which problems of adaptation to pregnancy influence the development of symptoms of perinatal depression via the presence of brooding and low maternal-fetal bonding, in addition to other risk factors previously established in the literature.
Study Design Representative sample of pregnant women in the third trimester of gestation (N = 594) completed an online survey that included sociodemographic data and measures of perinatal depression, adjustment to pregnancy, bonding, and brooding. Other risk factors were also assessed as covariates, such as previous history of depression, generalized anxiety, perceived social support, and experience of stressful life events. Descriptive and correlational analyses were performed on the scores obtained by the subjects with the different instruments. A path model was formulated to establish the pathways through which adjustment influences perinatal depression symptomatology. On the one hand, the presence of brooding (worst adjustment to pregnancy → high brooding → perinatal depression symptomatology), and on the other hand, the quality of maternal-fetal bonding (worst adjustment to pregnancy → poor quality fetal-maternal bonding → perinatal depression symptomatology) would act as a mediator.
Results The factors proposed by the literature were predictive of perinatal depressive symptomatology and the quality of adjustment to pregnancy. Problems adjusting to changes during pregnancy and experiencing it unsatisfactorily may predict individual differences in perinatal depressive symptoms. Significantly, this relationship was mediated by two key factors, the presence of brooding and low quality of the maternal-fetal bond.
Conclusion Our results provide evidence in favor of the existence of multiple paths through which difficulties in adapting to pregnancy can favor the occurrence of higher levels of perinatal depressive symptoms and identify new avenues for developing research in this area and preventive interventions empirically informed.
Platelet Function and Maturity and Related microRNA Expression in Whole Blood in Patients with ST-Segment Elevation Myocardial Infarction
Authors: Pedersen Oliver Buchhave , Hvas Anne-Mette , Pasalic Leonardo , Kristensen Steen Dalby , Grove Erik Lerkevang , Nissen Peter H. 
Published: October 2023

Background Reduced effect of antiplatelet therapy has been reported in patients with ST-segment elevation myocardial infarction (STEMI). MicroRNAs (miRs) may influence platelet function and maturity, and subsequently the effect of antiplatelet therapy.
Objectives We aimed to explore the association between miR expression and platelet function and maturity in patients with acute STEMI and healthy individuals.
Methods We performed an observational study of STEMI patients admitted directly to primary percutaneous coronary intervention. Patients were treated with antiplatelet therapy according to guidelines. Within 24 hours after admission, blood samples were obtained to measure: the expression of 10 candidate miRs, platelet function markers using advanced flow cytometry, platelet aggregation, serum thromboxane B2, and platelet maturity markers. Furthermore, blood samples from healthy individuals were obtained to determine the normal variation.
Results In total, 61 STEMI patients and 50 healthy individuals were included. STEMI patients had higher expression of miR-21–5p, miR-26b-5p, and miR-223–3p and lower expression of miR-150–5p, miR423–5p, and miR-1180–3p than healthy individuals. In STEMI patients, the expression of miR-26b-5p showed the most consistent association with platelet function (all p-values <0.05, Spearman's rho ranging from 0.27 to 0.41), while the expression of miR-150–5p and miR-223–3p showed negative associations with platelet function. No association between miR expression and platelet maturity markers was observed.
Conclusion In patients with STEMI, the expression of six miRs was significantly different from healthy individuals. The expression of miR-26b-5p may affect platelet function in acute STEMI patients and potentially influence the effect of antiplatelet therapy.
Thickness effect of thin-film barrier layers for enhanced long-term operation of solid oxide fuel cells
Authors: Bernadet L. , Buzi F. , Baiutti F. , Segura-Ruiz J. , Dolado J. , Montinaro D. , Torrell M. , Morata A. , Tarancón A. 
Published: October 2023

Highly efficient solid oxide cells are one of the most promising technologies for a sustainable future based on renewable hydrogen. The diffusion barrier layer employed between zirconia-based electrolytes and state-of-the-art oxygen electrodes aims to limit the formation of electrically insulating secondary phases that dramatically reduce the cells’ performance. Conventional barrier layers manufactured by screen-printing technology lead to porous microstructures that enable the formation of insulating SrZrO3, partially blocking the active area of the cells. Opposite, homogeneous and dense barrier layers have proven to be the ultimate solution to limit interdiffusion, substantially improving the cells’ performance. Despite the relevance of this solution, the impact of the barrier layer thickness on the final performance of the cells is still unknown. In this work, gadolinia-doped ceria barrier layers with thicknesses between 200 and 800 nm made by pulsed laser deposition were studied in button cells. Excellent electrochemical performance was obtained for all the cells, improving 45% of the power output of the reference counterparts. Moreover, durability tests performed on the cell with the thinnest layer (200 nm) did not show any measurable degradation for 3500 h of continuous operation under high current densities of 0.77 A cm−2 (∼0.87 V) at 750 °C. Post-mortem characterization by synchrotron nano-x-ray fluorescence of a pristine cell and the aged cell allowed us to observe that some spots of SrZrO3 were present at the cathode/electrolyte interface since the cell manufacturing step without increasing during long-term operation. Indeed, the discontinuity of this insulating phase seems not to be critical for cell operation.
Optical characterization of high performance mirrors based on cavity ringdown time measurements with 6 degrees of freedom mirror positioning
Authors: Gutierrez N. , Degallaix J. , Hofman D. , Michel C. , Pinard L. , Morville J. , Battesti R. , Cagnoli G. 
Published: October 2023

An instrument capable of measuring optical losses, transmission, and the radius of curvature of high reflectivity mirrors is presented. The measurement setup consists of two remote controlled hexapod systems with 6 degrees of freedom placed inside a vacuum enclosure. Mirror loss measurements are performed via the cavity ring-down time method using a linear resonant two-mirror Fabry–Perot cavity configuration. The use of high-precision positioning systems enables cavity loss mapping by transversely scanning the position of the cavity end mirror. Mirror surfaces of up to 30 mm in diameter can be scanned, and the cavity length can be tuned by 120 mm.
Spin state and magnetic coupling in polynuclear Ni(II) complexes from density functional theory: is there an optimal amount of Fock exchange?
Authors: Manukovsky Nurit , Kamieniarz Grzegorz , Kronik Leeor 
Published: October 2023

Reliable prediction of the ground-state spin and magnetic coupling constants in transition-metal complexes is a well-known challenge for density functional theory (DFT). One popular strategy for addressing this long-standing issue involves the modification of the fraction of Fock exchange in a hybrid functional. Here we explore the viability of this approach using three polynuclear metal-organic complexes based on a Ni4O4 cubane motif, having different ground state spin values (S = 0, 2, 4) owing to the use of different ligands. We systematically search for an optimum fraction of Fock exchange, across various global, range-separated, and double hybrid functionals. We find that for all functionals tested, at best there only exists a very narrow range of Fock exchange fractions which results in a correct prediction of the ground-state spin for all three complexes. The useful range is functional dependent, but general trends can be identified. Typically, at least two similar systems must be used in order to determine both an upper and lower limit of the optimal range. This is likely owing to conflicting demands of minimizing delocalization errors, which typically requires a higher percentage of Fock exchange, and addressing static correlation, which typically requires a lower one. Furthermore, we find that within the optimal range of Fock exchange, the sign and relative magnitude of Ni–Ni magnetic coupling constants are reasonably well reproduced, but there is still room for quantitative improvement in the prediction. Thus, the prediction of spin state and magnetic coupling in polynuclear complexes remains an ongoing challenge for DFT.
A nonlinear dynamic hysteresis model with magnetic-thermal-stress-fluid coupling effect for hydraulically amplified magnetostrictive actuator
Authors: Li Yuesong 
Published: October 2023

The hydraulic amplified magnetostrictive actuator (HAMA) has the advantages of large output displacement and fast response speed, but it is affected by coupling effects of electromagnetism, temperature, prestress, fluid, and other factors. In order to accurately analyze its performance, it is necessary to establish a nonlinear dynamic model including the coupling effect of eddy current loss, hysteresis, prestress, temperature, and fluid. First, a nonlinear magnetostrictive model including the magnetic-thermal-stress coupling effect is developed from the perspective of free energy. Based on the conservation of magnetization energy, the influence term of the eddy current is added to the anhysteretic magnetization and a nonlinear dynamic magnetization model including the effect of eddy current is developed. Based on the fluid transmission theory and HAMA’s equivalent dynamic model, a dynamic model of HAMA was established. Finally, a nonlinear dynamic hysteresis model with the magneto-thermal-stress-fluid coupling effect of HAMA is developed, and the performance of HAMA was studied by simulation and experiments. The results show that the output displacement is from −58.2 to 58.2 µm when the control current changes from −2 to 2 A, and the simulation results have a better agreement with the experiment result when the frequency is less than 200 Hz.
Does your regional variety help you acquire an additional language?
Authors: Perpiñán Sílvia , Montrul Silvina 
Published: October 2023

Abstract
This study investigates Differential Object Marking (DOM) in Italian speakers from two dialectal areas–North and
South Italy–learning Spanish. Southern Italo-Romance varieties exhibit a DOM system through a-marking, like
Spanish, whereas the Northern varieties, like Standard Italian, only allow DOM with pronouns. Given the structural differences and
similarities among these typologically close languages, we ask whether a stigmatized oral regional variety has the potential to
transfer in the acquisition of additional languages. Participants (n = 103) completed an acceptability judgment
task (AJT) and an oral production task testing DOM in [±animate, ±definite] DP contexts. The results revealed differences
modulated by proficiency in the written AJT that moderately favored the Northern learners and in the oral production task that
favored the Southern learners. These findings suggest that low-prestige varieties may not have the full potential to transfer at
early stages of acquisition due to their inhibition in formal contexts, but that they can emerge in less formal tasks. We argue
that current theoretical models that prioritize linguistic proximity as the primary source of transfer at initial stages of L3 acquisition are
unable to capture revealing patterns from understudied sociolinguistic contexts that bring new light to the study of
multilingualism.
Galaxy rotation curve in hyperconical universes: a natural relativistic MOND
Authors: Monjo Robert 
Published: October 2023

Abstract
Modified Newtonian dynamics (MOND) and similar proposals can (at least partially) explain the excess rotation of galaxies or the equivalent mass-discrepancy acceleration, without (or by reducing) the requirement of dark matter halos. This paper develops a modified gravity model to obtain local limit to the general relativity (GR) compatible with a cosmological metric different to the standard Friedmann–Lemaître–Robertson–Walker metric. Specifically, the paper uses a distorted stereographic projection of hyperconical universes, which are 4D hypersurfaces embedded into 5D Minkowski spacetime. This embedding is a key in the MOND effects found in galactic scales. To adequately describe the mass-discrepancy acceleration relation, centrifugal force would present a small time-like contribution at large-scale dynamics due to curvature of the Universe. Therefore, the Lagrangian density is very similar to the GR but with subtracting the background curvature (or vacuum energy density) of the perturbed hyperconical metric. Results showed that the proposed model adjusts well to 123 galaxy rotation curves obtained from the Spitzer Photometry and Accurate Rotation Curves database, using only a free parameter.