bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative somatosensory evaluation of recipient and donor sites of subepithelial connective tissue grafts
Authors: Nascimento Esther Belotti do , Jurkevicz Talyta Sasaki , Bonjardim Leonardo Rigoldi , Sant`Ana Adriana Campos Passanesi , Damante Carla Andreotti , Zangrando Mariana Schutzer Ragghianti 
Published: February 2024

Abstract

Objectives
The subepithelial connective tissue graft (SCTG) plus coronal advanced flap is commonly evaluated by clinical parameters, but potential sensory changes (patients’ perception of painful or painless sensations) need to be further explored. This study aimed to qualitatively evaluate the somatosensory profile of recipient and palatal donor sites of SCTG.
Materials and Methods
Sensory tests were applied at SCTG recipient and donor sites at baseline, after 3 and 6 months. A single calibrated examiner applied Douleur Neuropathique 4 questionnaire (DN4), qualitative sensory test (QualST), discriminating the areas as hypersensitive, hyposensitive or normosensitive, and two-point acuity test. Descriptive statistics, non-parametric Kruskal Wallis test for QualST evaluation and ANOVA for Two-point test (p < 0.05) were used.
Results
QualST revealed that recipient areas presented no significant differences in tactile, pressure and thermal tests. Brush test revealed hyposensitivity after 3 months (p = 0.03). In donor areas, only thermal evaluation showed a significant difference (p = 0.01), being hypersensitive after 3 months and hyposensitive after 6 months. At baseline, all evaluations in recipient and donor areas were normosensitive. According to DN4, no patient reported pain in recipient and donor sites. Non-painful sensory perception was reported as numbness in recipient (3.14% of patients) and donor (18.4%) areas. No significant differences were found for two-point acuity test values.
Conclusions
The extent to which these alterations in sensations affected oral functions showed no impairment. Clinical Relevance: Although some punctual somatosensory changes occurred, they did not disable important oral functions, thus reinforcing the positive results obtained with periodontal plastic surgeries.
A SuperLearner approach for predicting diabetic kidney disease upon the initial diagnosis of T2DM in hospital
Authors: Lin Xiaomeng , Liu Chao , Wang Huaiyu , Fan Xiaohui , Li Linfeng , Xu Jiming , Li Changlin , Wang Yao , Cai Xudong , Peng Xin 
Published: February 2024

Abstract

Background Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM), with patients typically remaining asymptomatic until reaching an advanced stage. We aimed to develop and validate a predictive model for DKD in patients with an initial diagnosis of type 2 diabetes mellitus (T2DM) using real-world data. Methods We retrospectively examined data from 3,291 patients (1740 men, 1551 women) newly diagnosed with T2DM at Ningbo Municipal Hospital of Traditional Chinese Medicine (2011–2023). The dataset was randomly divided into training and validation cohorts. Forty-six readily available medical characteristics at initial diagnosis of T2DM from the electronic medical record were used to develop prediction models based on linear, non-linear, and SuperLearner approaches. Model performance was evaluated using the area under the curve (AUC). SHapley Additive exPlanation (SHAP) was used to interpret the best-performing models. Results Among 3291 participants, 563 (17.1%) were diagnosed with DKD during median follow-up of 2.53 years. The SuperLearner model exhibited the highest AUC (0.7138, 95% confidence interval: [0.673, 0.7546]) for the holdout internal validation set in predicting any DKD stage. Top-ranked features were WBC_Cnt*, Neut_Cnt, Hct, and Hb. High WBC_Cnt, low Neut_Cnt, high Hct, and low Hb levels were associated with an increased risk of DKD. Conclusions We developed and validated a DKD risk prediction model for patients with newly diagnosed T2DM. Using routinely available clinical measurements, the SuperLearner model could predict DKD during hospital visits. Prediction accuracy and SHAP-based model interpretability may help improve early detection, targeted interventions, and prognosis of patients with DM.
Nurses’ practice towards Evidence Based Practice in nursing process and associated factors in South Wollo Zone Public Hospitals, Northeast Ethiopia: Mixed Method
Authors: Edmealem Afework , Fentaw Nurye , Bekele Abebe , Tegegne Belachew , Mohammed Jemal , Liknaw Tiliksew 
Published: February 2024

Abstract

Background: Evidence-based practice is clinical decision-making using the best evidence available in the context of individual patients' preferences and clinical expertise. It is serving as a crucial instrument for the health science disciplines to minimize the theory-practice gap. Despite clinical effectiveness and patient safety being among its successes, its practice in the nursing process was low.
Methods: An institution-based-based-sectional study with a mixed method was employed from April 1 to 30, 2023, among 419 nurses for the quantitative part and 15 others for the qualitative part. The data were collected using structured, pretested, self-administered questionnaires. Simple random sampling was used to select participants. The bivariable analysis was done primarily, and variables with a p-value < 0.25 were further examined using a multivariable logistic regression model to control con-founders. Then, variables having a p-value less than 0.05 with a 95% CI were used to declare significantly associated factors.
Result: A total of 434 nurses were involved in this study; 15 of them were for the qualitative part and 419 were for the quantitative part, with a response rate of 100%. Nurses who had poor implementation of evidence-based practice in the nursing process were 191 (45.6%). Participants who were working at general hospitals (AOR = 3.37, 95% CI 1.39–8.18) and comprehensive and specialized hospitals (AOR = 7.29, 95% CI 3.06–17.31), lack of training about evidence-based practice (AOR = 2.50, 95% CI 1.36-4.56), and lack of internet access (AOR = 2.46, 95% CI 1.43–4.23) were factors associated with poor levels of nurses’ practice towards evidence-based practice in the nursing process.
Conclusion: Nurses’ practice towards evidence-based practice in the nursing process was low. Age, working in general hospitals, working in comprehensive and specialized hospitals, lack of training, and lack of internet access were factors that had associations with a poor level of nurses’ practice towards evidence-based practice in the nursing process. Hence, hospital managers give attention to internet access and training about evidence-based practice.
Viral Induced Reactive Plasmacytosis
Authors: Bhatnagar Aishwarya , Joshi Anamika , Morya Kailash Chandra , Kewalia Kailash 
Published: February 2024

Abstract
Plasmacytosis is a condition of increased number of plasma cells in tissues, exudate or blood as a defence mechanism. Transient immune reactions in any infection or autoimmune disorder may present as reactive plasmacytosis that might rarely also manifest as plasma cell mucositis. Reactive plasmacytosis has been reported in several viral infections and has been found to completely disappear within 2 weeks. Complete clinical evaluation, individualised investigation and more specific tests are required to rule out these oral manifestations. Thus, we hereby present an extremely rare condition wherein Human Papilloma Virus (HPV) led to reactive plasmacytosis.
TUMDOT–MUC: Data Collection and Processing of Multimodal Trajectories Collected by Aerial Drones
Authors: Kutsch Alexander , Margreiter Martin , Bogenberger Klaus 
Published: February 2024

Abstract

Currently available trajectory data sets undoubtedly provide valuable insights into traffic events, the behaviour of road users and traffic flow theory, thus enabling a wide range of applications. However, there are still shortcomings that need to be addressed: (i) the continuous temporal recording (ii) of a coherent area covering several intersections (iii) with the detection of all road users, including pedestrians and cyclists. Therefore, this study focuses on the design of a large-scale aerial drone observation in the city of Munich, Germany, as well as the processing steps and the description of the resulting data set. Using twelve camera-equipped, unmanned aerial drones, the observation monitored an inner urban road section with a length of 700 meters continuously for several hours during the afternoon peak hours on two working days. The trajectories of all road users were then extracted from the videos and post-processed in order to obtain a coherent and accurate data set. The resulting trajectories contain the information on the category, dimensions, location, velocity, acceleration and orientation of each road user at each frame, merged continuously in time and space across several drone observation areas and subsequent time slots. The data therefore includes various interactions of different modes of motorized traffic and active mobility users like pedestrians and cyclists. The whole data set and supporting data is available open source for research purposes to ensure global accessibility.
Hepatitis C care among people with HIV in Puerto Rico: A mixed-methods study
Authors: Rodriguez-Diaz Carlos E. , Malave-Rivera Souhail M. , Vargas-Molina Ricardo L. , Soler Miriam , Otero-Cruz Ilia M. , Aponte Fernando , Agront Nancy 
Published: February 2024

Abstract

Background
A significant proportion of people with HIV are coinfected with Hepatitis C Virus (HCV). Many of these individuals who are chronically infected with HCV will develop complications. Effective treatments are available to cure HCV infection and reduce morbidity and mortality, but most people with HCV do not receive it. The present study aimed at describing a sample of people co-infected with HIV and HCV and exploring barriers and facilitators to HCV care in Puerto Rico.
Methods
Using a mixed-method design, a total of n = 113 randomly selected medical records of people with HIV and HCV coinfection were reviewed. Then, we conducted 12 qualitative interviews with HCV treatment stakeholders (e.g., physicians and pharmacists).
Results
Findings indicate that coinfected individuals have been living with HIV for an average of 16.6 ± 7.7 years. and the average time since the latest HCV treatment was 3.9 ± 4.5 years. The most common HCV genotype was 1a (26.5%; n = 30), 40.7% of the participants were treated with direct-acting antivirals, and 42 (91%) achieved a sustained virologic response. Interview findings suggest that access to HCV treatment is limited mainly due to costs and lack of insurance coverage and that those engaged in HCV care facilitate access to appropriate services.
Conclusions
Expanding coverage and increasing the number of physicians who could prescribe HCV treatment might reduce the gaps in HCV treatment accessibility and use among people coinfected with HIV and facilitate HCV elimination. Culturally appropriate interventions remain needed to address low HCV disease awareness and stigma.
Rhabdomyolysis induced by protective restraints in catatonic schizophrenic patient: a case report and literature review
Authors: Zhou Sumiao , She Shenglin , Wu Qiuxia , Zheng Yingjun , Kuang Qijie 
Published: February 2024

Abstract

Background Rhabdomyolysis is a syndrome characterized by muscle necrosis and the entry of myocyte contents into the circulation. Creatine kinase (CK) levels are usually significantly elevated in this syndrome. In psychiatry, it is common to find patients with creatine kinase (CK) levels significantly higher than normal values, sometimes exceeding 10 times the upper limit. This CK elevation may be due to the occurrence of rhabdomyolysis. Severe rhabdomyolysis can lead to acute kidney injury, which can be life-threatening. Case presentation: This report describes the case of a 54-year-old woman with catatonic schizophrenia with a stupor who was admitted to the hospital without CK elevation or muscle damage but developed rhabdomyolysis after protective restraint. The patient had no history of traumatic or exertional illness prior to admission and no family history of rhabdomyolysis. After fluid resuscitation, the patient's rhabdomyolysis resolved. In addition, in combination with modified electroconvulsive therapy (MECT), the patient’s stupor symptoms disappeared. Conclusions This case suggests that psychiatrists should be aware of rhabdomyolysis when treating patients with acute schizophrenia who may require additional restraints. Severe rhabdomyolysis can be life-threatening. Therefore, when protective restraints are needed, psychiatrists should strictly follow the guidelines for protective restraint use to avoid additional harm to patients owing to medical reasons.
Prolongation of jaundice in infants at the University Clinical Center of Kosovo during 2020
Authors: Shala Labeat , Duriqi Aida , Duriqi Adnan , Dukaj Genc , Kurmehaj Granit 
Published: February 2024

Abstract
Objective
The aim of this paper is to gain updated knowledge about jaundice in latents and the paper will mainly focus on: frequency, etiology, predisposing factors, pathophysiology, genetics, signs and symptoms, systemic manifestations, forms of jaundice, diagnosis, treatment and extension of jaundice in latents. The objective of this paper is to investigate the cases of jaundice in neonates, in the Department of Neonatology, near the University Clinical Center of Kosovo.
Methods
The research is retrospective and was carried out in the Department of Neonatology, near the University Clinical Center of Kosovo. The subjects of the study were newborns with jaundice. The literature search was carried out through the PubMed and Google Scholar platforms.
Results
The study was conducted at the Clinic of Neonatology, near the University Clinical Center of Kosovo. In this study, data were obtained for patients hospitalized during 2020 with prolonged jaundice. A total of 842 newborns were hospitalized, of which 123 had jaundice. According to the 12-month study during 2020, it is found that 120 have fully recovered, while 3 of them have died. The gender structure shows that men participate in 72 cases (58.53%), while women in 51 cases (41.46%).
Conclusion
Timely diagnosis and adequate treatment of complications has made this important health problem in our country well treated and our results are similar to those of other centers cited in contemporary literature on this topic.
Production and identification of melon double haploid induced by wide hybridization between melon and cucumber
Authors: Bi Yansheng , Zheng Lina , An Luxi , Wang Yuhui , Zhang Yongping , Qian Chuntao 
Published: February 2024

Abstract

Parthenogenesis is an important way for melon (Cucumis melo L.) haploid production, but difficulties remain in low induction rate, embryo rescue, and chromosome doubling. Wide hybridization of Gramineae crops can directly obtain maternal haploids without embryo rescue and then form double haploids by chromosome doubling. However, this method has not been applied to the melon. To broaden the double haploid creation pathway in melon, seven cross combinations of the genus Cucumis were used for wide hybridization. After pollination, the ovary was treated with forchlorfenuron and thidiazuron to promote embryonic development and chromosome doubling. Results demonstrated that the fruit setting rate was 67.67–84.00%. However, most of the fruits were parthenocarpic (empty seeds), and only one fruit from the combination of BPC-4 (C. melo ‘baipicui’) × YPJ-6 (C. sativus L.) obtained 3 mature seeds. After the 3 seeds germinate, only one seed develops into a plant. Then, the plant (F1) was selfed and obtained F2 and F3. Chromosome counts showed that F2 was diploid (2n = 2x = 24). Compared to BPC-4, the visible variation of compact on botanical traits appeared in F2 and F3 and was uniform in population among F2 and F3. 27 SSR polymorphism markers demonstrated that the maternal origin of gene locus and homozygosity of the F2 hybrid plants. Genome resequencing analysis showed that the F2 genomes were further purified by 0.24% compared to BPC-4. Therefore, the hybrid offsprings were double haploid. In conclusion, we are the first to induce a melon double haploid by wide hybridization.
On the importance of a clear definition of time horizon for time-to-event dynamic predictions: a systematic review and a concrete illustration in kidney transplantation
Authors: Chabeau Lucas , Bonnemains Vincent , Rinder Pierre , Giral Magali , Desmée Solène , Dantan Etienne 
Published: February 2024

Abstract

Background.
Time-to-event dynamic predictions are defined as the probability to survive until a defined time horizon given being event-free at landmark times and given available predictive variables at such prediction times. From two different mathematical formulations, dynamic predictions can either predict the survival probability until a final time horizon or until the end of a sliding horizon window. We aim to illustrate the need to clearly define the time horizon to correctly interpret the prognostic performances.
Methods.
First, following the PRISMA, CHARMS and TRIPOD recommendations, we conducted a systematic review of articles concerning dynamic predictions to assess how the time horizon was reported in the literature. Second, using a sample of 2,523 kidney recipients, we assessed the prognostic capacities of the Dynamic predictions of Patient and kidney Graft survival (DynPG) using either a final time horizon or a sliding horizon window.
Results.
Of 172 references retrieved about dynamic predictions, 102 articles were included in the systematic review. We notably observed that 71 (69.6%) used a sliding horizon window to assess the prognostic performance while 18 (17.7%) used a final time horizon. We also identified 13 articles (12.7%) where the time horizon was not defined clearly (or at all). Our concrete application in kidney transplantation shows that discrimination and calibration are not the same when comparing the two time horizon definitions. On one hand, for a 5-year sliding horizon window, the discrimination slightly increased as the landmark times increased, and we also observed that DynPG is reasonably well calibrated, particularly for the earliest landmark times. On the other hand, for an 11-year final time horizon, the discrimination was high for the earliest landmark times and increased over time, while the calibration plot revealed predictions were underestimated for the earliest landmark times and overestimated for later ones.
Conclusions.
Our systematic review identified a clear heterogeneity in the time horizon definition used, and an absence of a clear time horizon definition in a part of published articles. Our study advocates for improving the reporting when studying dynamic prediction scoring systems since the prognostic performances and interpretation differ according to the time horizon definition.
Serum Osteocalcin as a Risk Factor for osteosarcopenia in elderly patients with T2DM
Authors: Li Junyan , Si Qinqin , yuan chuyue , Li Na , Yuan Niuniu , Shen Huimin 
Published: February 2024

Abstract
Background
Osteosarcopenia(OS) has become a global public health problem, which highly influence the life quality for the elderly patients with type 2 diabetes mellitus (T2DM). However, the diagnostic processes is complex and difficult due to lack of the exact diagnostic biomarker. Thus, it is necessary to screen the sensitive biomarker of musculoskeletal metabolism in older patient with T2DM. Previous studies have suggested that osteocalcin mainly involved into the development of musculoskeletal metabolism. This study aimed to investigate the relationship between osteocalcin and osteosarcopenia in elderly patients with T2DM.
Methods
Here we designed a cross-sectional study that included 224 elderly patients with T2DM. We collected the general data and experimental indexes of those patients including bone mineral density (BMD), skeletal muscle index (SMI), grip strength, and gait speed were measured. All subjects were divided into 5 groups based on the above indicators: Controls (CO), Pre-osteosarcopenia(P-OS),Sarcopenia (SP), Osteoporosis(OP), Osteosarcopenia (OS).Meanwhile we examined several bone metabolism-related indexes such as osteocalcin (OC), β-collagen special sequence (β-CTX), and type I procollagen N-terminal propeptide (PINP). Logistic regression analysis was used to analyze the relationship between osteoscarsopenia and osteocalcin.
Results
The results showed the levels of OC, β-CTX, and PINP increased in the osteosarcopenia group. BMD, SMI, handgrip strength and calf circumference decreased with the increasing osteocalcin concentrations (p < 0.05). A higher serum osteocalcin level was associated with higher risk of OS (OR = 10.84, 95% CI (1.24-95.00)) in the logistic regression model.
Conclusion
Osteocalcin might be used as the important biomarker to predict the risk of OS in elderly type 2 diabetes.
Analyzing and enhancing the porthole die design for extruding a complicated AA7005 profile
Authors: Nguyen Thanh-Cong , Truong Tat-Tai , Wang Jun-Wei , Sheu Jinn-Jong , Hsu Chih-Lin , Hsu Quang-Cherng 
Published: February 2024

Abstract

Porthole extrusion enables the production of aluminum profiles with intricate cross-sections. It can efficiently shape complex profiles; however, few studies have investigated complex hot extrusions using porthole dies, particularly with 7000-series aluminum alloys. Although 7000-series aluminum alloys are renowned for their superior strength, they have poor extrudability, especially for complex extrusion profiles. Implementing an effective die design is essential for avoiding extrusion defects and maximizing extrusion performance. In this study, a porthole extrusion method for a complex profile was developed for AA7005, a medium-high-strength aluminum alloy. Computer-aided engineering simulations were employed to analyze die strength and forecast the flow of the material. After the first trial with the initial design, the lower die was slightly modified. However, following this minor modification, there were occurrences of material blockages. A major revision of die design was then performed, in which bearing length, die runout, and pocket shape were all adjusted. For validation, extrusion testing was conducted, and the effectiveness of the modifications was determined. Finally, the extrusion processes of the modified and initial die designs were compared, including their metal flow behavior, maximum extrusion forces, and product dimensions. The study highlights a well-rounded methodology that incorporates simulation and empirical results to comprehensively understand the challenges of complicated profile extrusion processes with medium-high-strength aluminum alloy.