bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-cubic-kilometre neutrino telescope in the western Pacific Ocean
Authors: Ye Z. P. , Hu F. , Tian W. , Chang Q. C. , Chang Y. L. , Cheng Z. S. , Gao J. , Ge T. , Gong G. H. , Guo J. , Guo X. X. , He X. G. , Huang J. T. , Jiang K. , Jiang P. K. , Jing Y. P. , Li H. L. , Li J. L. , Li L. , Li W. L. , Li Z. , Liao N. Y. , Lin Q. , Lin J. , Liu F. , Liu J. L. , Liu X. H. , Miao P. , Mo C. , Morton-Blake I. , Peng T. , Sun Z. Y. , Tang J. N. , Tang Z. B. , Tao C. H. , Tian X. L. , Wang M. X. , Wang Y. , Wang Y. , Wei H. D. , Wei Z. Y. , Wu W. H. , Xian S. S. , Xiang D. , Xu D. L. , Xue Q. , Yang J. H. , Yang J. M. , Yu W. B. , Zeng C. , Zhang F. Y. D. , Zhang T. , Zhang X. T. , Zhang Y. Y. , Zhi W. , Zhong Y. S. , Zhou M. , Zhu X. H. , Zhuang G. J. 
Published: October 2023

AbstractNext-generation neutrino telescopes with substantially improved sensitivity are required to pinpoint the sources of the diffuse astrophysical neutrino flux detected by IceCube and uncover the century-old puzzle of cosmic-ray origins. A detector near the Equator will provide a unique viewpoint of the neutrino sky, complementing IceCube and other neutrino telescopes in the Northern Hemisphere. Here we present results from an expedition to the northeastern region of the South China Sea, in the western Pacific Ocean. A favourable neutrino telescope site was found on an abyssal plain at a depth of ~3.5 km. At depths below 3 km, the sea current speed, water absorption and scattering lengths for Cherenkov light were measured to be vc < 10 cm s−1, λabs ≈ 27 m and λsca ≈ 63 m, respectively. Accounting for these measurements, we present the design and expected performance of a next-generation neutrino telescope, Tropical Deep-sea Neutrino Telescope (TRIDENT). With its advanced photon-detection technology and large dimensions, TRIDENT expects to observe the IceCube steady source candidate NGC 1068 with 5σ significance within 1 year of operation. This level of sensitivity will open a new arena for diagnosing the origin of cosmic rays and probing fundamental physics over astronomical baselines.
A global dataset for the production and usage of cereal residues in the period 1997–2021
Authors: Smerald Andrew , Rahimi Jaber , Scheer Clemens 
Published: October 2023

AbstractCrop residue management plays an important role in determining agricultural greenhouse gas emissions and related changes in soil carbon stocks. However, no publicly-available global dataset currently exists for how crop residues are managed. Here we present such a dataset, covering the period 1997–2021, on a 0.5° resolution grid. For each grid cell we estimate the total production of residues from cereal crops, and determine the fraction of residues (i) used for livestock feed/bedding, (ii) burnt on the field, (iii) used for other off-field purposes (e.g. domestic fuel, construction or industry), and (iv) left on the field. This dataset is the first of its kind, and can be used for multiple purposes, such as global crop modelling, including the calculation of greenhouse gas inventories, estimating crop-residue availability for biofuel production or modelling livestock feed availability.
In-situ experiment reveals CO2 enriched fluid migration in faulted caprock
Authors: Weber Ulrich Wolfgang , Rinaldi Antonio Pio , Roques Clément , Wenning Quinn C. , Bernasconi Stefano M. , Brennwald Matthias S. , Jaggi Madalina , Nussbaum Christophe , Schefer Senecio , Mazzotti Marco , Wiemer Stefan , Giardini Domenico , Zappone Alba , Kipfer Rolf 
Published: October 2023

AbstractThe sealing characteristics of the geological formation located above a CO2 storage reservoir, the so-called caprock, are essential to ensure efficient geological carbon storage. If CO2 were to leak through the caprock, temporal changes in fluid geochemistry can reveal fundamental information on migration mechanisms and induced fluid–rock interactions. Here, we present the results from a unique in-situ injection experiment, where CO2-enriched fluid was continuously injected in a faulted caprock analogue. Our results show that the CO2 migration follows complex pathways within the fault structure. The joint analysis of noble gases, ion concentrations and carbon isotopes allow us to quantify mixing between injected CO2-enriched fluid and resident formation water and to describe the temporal evolution of water–rock interaction processes. The results presented here are a crucial complement to the geophysical monitoring at the fracture scale highlighting a unique migration of CO2 in fault zones.
Small Island Developing States under threat by rising seas even in a 1.5 °C warming world
Authors: Vousdoukas Michalis I. , Athanasiou Panagiotis , Giardino Alessio , Mentaschi Lorenzo , Stocchino Alessandro , Kopp Robert E. , Menéndez Pelayo , Beck Michael W. , Ranasinghe Roshanka , Feyen Luc 
Published: October 2023

AbstractSmall Island Developing States (SIDS) have long been recognized as some of the planet’s most vulnerable areas to climate change, notably to rising sea levels and coastal extremes. They have been crucial in raising ambitions to keep global warming below 1.5 °C and in advancing the difficult debate on loss and damage. Still, quantitative estimates of loss and damage for SIDS under different mitigation targets are lacking. Here we carry out an assessment of future flood risk from slow-onset sea-level rise and episodic sea-level extremes along the coastlines of SIDS worldwide. We show that by the end of this century, without adaptation, climate change would amplify present direct economic damages from coastal flooding by more than 14 times under high-emissions scenarios. Keeping global warming below 1.5 °C could avoid almost half of unmitigated damage, depending on the region. Achieving this climate target, however, would still not prevent several SIDS from suffering economic losses that correspond to considerable shares of their GDP, probably leading to forced migration from low-lying coastal zones. Our results underline that investments in adaptation and sustainable development in SIDS are urgently needed, as well as dedicated support to assisting developing countries in responding to loss and damage due to climate change.
Utilization of lignocellulosic hydrolysates for photomixotrophic chemical production in Synechococcus elongatus PCC 7942
Authors: Gonzales Jake N. , Treece Tanner R. , Mayfield Stephen P. , Simkovsky Ryan , Atsumi Shota 
Published: October 2023

AbstractTo meet the need for environmentally friendly commodity chemicals, feedstocks for biological chemical production must be diversified. Lignocellulosic biomass are an carbon source with the potential for effective use in a large scale and cost-effective production systems. Although the use of lignocellulosic biomass lysates for heterotrophic chemical production has been advancing, there are challenges to overcome. Here we aim to investigate the obligate photoautotroph cyanobacterium Synechococcus elongatus PCC 7942 as a chassis organism for lignocellulosic chemical production. When modified to import monosaccharides, this cyanobacterium is an excellent candidate for lysates-based chemical production as it grows well at high lysate concentrations and can fix CO2 to enhance carbon efficiency. This study is an important step forward in enabling the simultaneous use of two sugars as well as lignocellulosic lysate. Incremental genetic modifications enable catabolism of both sugars concurrently without experiencing carbon catabolite repression. Production of 2,3-butanediol is demonstrated to characterize chemical production from the sugars in lignocellulosic hydrolysates. The engineered strain achieves a titer of 13.5 g L−1 of 2,3-butanediol over 12 days under shake-flask conditions. This study can be used as a foundation for industrial scale production of commodity chemicals from a combination of sunlight, CO2, and lignocellulosic sugars.
Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies
Authors: Lipov Alex , Jurgens Sean J. , Mazzarotto Francesco , Allouba Mona , Pirruccello James P. , Aguib Yasmine , Gennarelli Massimo , Yacoub Magdi H. , Ellinor Patrick T. , Bezzina Connie R. , Walsh Roddy 
Published: October 2023

AbstractDiscrete categorization of Mendelian disease genes into dominant and recessive models often oversimplifies their underlying genetic architecture. Cardiomyopathies (CMs) are genetic diseases with complex etiologies for which an increasing number of recessive associations have recently been proposed. Here, we comprehensively analyze all published evidence pertaining to biallelic variation associated with CM phenotypes to identify high-confidence recessive genes and explore the spectrum of monoallelic and biallelic variant effects in established recessive and dominant disease genes. We classify 18 genes with robust recessive association with CMs, largely characterized by dilated phenotypes, early disease onset and severe outcomes. Several of these genes have monoallelic association with disease outcomes and cardiac traits in the UK Biobank, including LMOD2 and ALPK3 with dilated and hypertrophic CM, respectively. Our data provide insights into the complex spectrum of dominance and recessiveness in genetic heart disease and demonstrate how such approaches enable the discovery of unexplored genetic associations.
Crop switching for water sustainability in India’s food bowl yields co-benefits for food security and farmers’ profits
Authors: Chakraborti Ruparati , Davis Kyle Frankel , DeFries Ruth , Rao Narasimha D. , Joseph Jisha , Ghosh Subimal 
Published: October 2023

AbstractGroundwater depletion due to agricultural intensification is a major threat to water and food security in the Indo-Gangetic Plain (IGP), a critical food bowl, home to 400 million people and currently producing 135 million metric tonnes of cereals. Among the solutions proposed to address this unsustainable water consumption, crop switching has received growing attention, yet its potential to produce co-benefits or trade-offs for other dimensions of sustainability (for example, food supply and farmers’ profits) remains largely unquantified. In this study, we developed and applied a crop switching optimization model for cereals in the IGP to maximize calorie production and farmers’ profits and minimize water consumption. We found that switching from rice to millets (pearl millet) and sorghum in the Kharif (monsoon) season and from wheat to sorghum in the Rabi (winter) season could potentially reduce water consumption by 32%, improve calorie production by 39% and increase farmers’ profits by 140%. We also found that switching crops offers a larger reduction in groundwater depletion and energy savings than improving irrigation efficiency (that is, from flood to drip irrigation). Our findings demonstrate the potential for crop switching to address the multidimensional sustainability challenges of the IGP, with possible application to other regions facing similar issues.
Surface Electromyography Biofeedback as an Adjuvant to Dysphagia Management: What It Is, What It Is Not, Why You Need It, and How to Get It
Authors: Constantinescu Gabriela , Garcia Renzo 
Published: October 2023

Purpose:
Surface electromyography (sEMG) has been used by speech-language pathologists (SLPs) as a biofeedback tool to enhance the benefits of dysphagia rehabilitation since as early as 1976. Despite being noninvasive and user-friendly, sEMG biofeedback is not widely adopted by clinicians, potentially due to challenges such as insufficient knowledge about its appropriate clinical applications and the burden of acquiring this technology for a busy clinician. This article aims to support SLPs in utilizing sEMG as a simple biofeedback tool for dysphagia management by providing an overview of the physiological and technological underpinnings of sEMG as well as practical guidance on interpreting sEMG signal, optimizing signal quality, and documenting findings at the end of a session. Moreover, the article emphasizes the vital role clinicians have in promoting ongoing innovation in their field by advocating for modern solutions. It provides a framework and examples of how to request technologies in the clinic to foster an environment of continuous improvement in the service provided to patients.

Conclusion:
This article aims to equip clinicians with the knowledge and skills necessary to utilize sEMG technology effectively and help their patients achieve optimal outcomes in dysphagia management.
Intoxication du chien par le raisin : diagnostic et prise en charge
Authors: Yaich Héla , Malek Atef 
Published: October 2023

Le chien est un animal particulièrement friand de raisins, ce qui le prédispose à une intoxication, qu’elle soit spontanée ou accidentelle.
Le raisin est riche en composés phénoliques auxquels le chien s’avère sensible, en développant notamment une néphrotoxicité. L’intoxication se manifeste par des signes digestifs, des signes d’insuffisance rénale aiguë et des dérèglements biologiques.
La prise en charge du chien intoxiqué est éliminatoire et symptomatique.
Le pronostic est fonction de la quantité ingérée et de l’état des principales fonctions de l’animal. ­Toutefois, il est réservé dès l’installation de la forme rénale, en raison des risques accrus d’éventuelles complications.
Prävention von nicht suizidalem selbstverletzendem Verhalten und Suizidalität an Schulen
Authors: Ullrich Janice , Walter Teresa , Fegert Jörg M. , Rassenhofer Miriam 
Published: October 2023

ZUSAMMENFASSUNG
Gegenstand und Ziel Der Artikel beinhaltet die Darstellung der Inhalte und erste Evaluationsergebnisse eines Online-Kurses zu den Themenbereichen nicht suizidales selbstverletzendes Verhalten (NSSV) und Suizidalität, welcher für Schulpersonal entwickelt wurde.
Material und Methoden Analyse der Evaluation eines Online-Kurses (N = 1177) zur Zufriedenheit mit dem Kurs und zur Umsetzbarkeit der erlernten Inhalte im Berufsalltag. Darüber hinaus erfolgte die Evaluation der ersten in Präsenz angebotenen ergänzenden Vertiefungsschulung (N = 19). Die Auswertung erfolgte mithilfe der Statistik-Software IBM SPSS.
Ergebnisse Bei den Teilnehmenden zeigt sich nach Bearbeitung der Basismodule ein überaus positiver Gesamteindruck des absolvierten Online-Kurses (M = 4,51; SD = 0,56) sowie eine daraus resultierende große Bereitschaft, den Kurs weiterzuempfehlen (M = 4,67; SD = 0,53). Darüber hinaus werden die vermittelten Inhalte als hilfreich und nützlich empfunden (M = 4,43; SD = 0,54). Auch die Evaluation der Vertiefungsveranstaltung ergab einen überaus positiven Gesamteindruck (M = 4,79; SD = 0,42). Beinahe alle Teilnehmenden würden den Workshop an ihre Kollegen weiterempfehlen (M = 4,89; SD = 0,32).
Schlussfolgerungen Auf Basis der Evaluation erweisen sich der entwickelte Online-Kurs und die ergänzend angebotene Vertiefungsschulung in Präsenz als zufriedenstellend und zielführend und somit als wichtige sowie erfolgreiche Instrumente für die Prävention von NSSV und Suizidalität bei Schülern.
Klinische Relevanz Je früher NSSV und suizidales Verhalten erkannt werden, desto erfolgsversprechender wirken sich Maßnahmen zur Verhaltensänderung aus. Die Sensibilisierung und Schulung von Schulpersonal hinsichtlich der Thematik NSSV und Suizidalität sind somit unerlässlich, um eine Früherkennung der Phänomene zu gewährleisten und Hilfsangebote zu installieren. Grundlegendes Wissen über die Themenbereiche kann darüber hinaus eine Reduktion von Stigmatisierung und eine Steigerung von Offenheit bei Schulpersonal erzielen, wodurch betroffenen Schülern eine haltgebende und richtungweisende Unterstützung geboten werden kann.
„Fall Risk Scoring“ in der ambulanten Ganganalyse: Validierung eines neuen Sturzrisikoassessments bei Heimbewohnern
Authors: Unger Eduard Witiko , Pohlemann Tim , Orth Marcel , Rollmann Mika F. R. , Menger Maximilian M. , Herath Steven C. , Histing Tina , Braun Benedikt J. 
Published: October 2023

ZusammenfassungStürze von älteren Heimbewohnern sind häufig. Individuelle Prävention kann die Wahrscheinlichkeit zu stürzen senken. Um den Präventionsbedarf zu erkennen, bedarf es einer systematischen
Erfassung des individuellen Sturzrisikos. In dieser Studie soll daher untersucht werden, inwiefern ein Sturzrisikoscore, gebildet aus mit einer erhöhten Sturzneigung assoziierten Gangparametern,
zwischen einer hoch sturzgefährdeten Gruppe und einer jungen gesunden Kontrollgruppe unterscheiden kann. Ein bereits publizierter Sturzrisikoscore wurde bei über 75-jährigen, sturzgefährdeten
Heimbewohnern sowie bei einer jungen, gesunden unter 40-jährigen Kontrollgruppe angewendet und ein individueller Score gebildet. Zusätzlich wurden die Sturzereignisse über einen Zeitraum von 12
Monaten erfasst. Nach Prüfung auf Normalverteilung wurde mittels Mittelwertvergleich und ROC-Analyse die Möglichkeit, Teilnehmer mithilfe des Scores zwischen älteren sturzgefährdeten Teilnehmern
und jungen, gesunden Personen zu differenzieren, getestet. Es wurden 18 Heimbewohner und 9 junge, gesunde Teilnehmer in die Analyse einbezogen. Unter den Älteren stürzten 15 mindestens einmal,
wobei insgesamt 37 Stürze innerhalb der 12 Monate erfasst wurden (2,06 ± 2,16; Range: 0–8). Unter den Jüngeren stürzte niemand. Dabei unterschied sich der Sturzrisikoscore der Heimbewohner von
dem der Jüngeren signifikant (9,2 ± 3,2 vs. 5,7 ± 2,2). Ebenso unterschied sich der Score zwischen Gestürzten und nicht Gestürzten signifikant (10,3 ± 1,8 vs. 5,2 ± 2,5). Die Gestürzten und
nicht Gestürzten konnte der Score mit einem Cut-off > 7,5 (AUC: 0,95) und einer Sensitivität von 86,7% differenzieren (Spezifität: 83,3%). Der gebildete Score erlaubt grundsätzlich die
Differenzierung zwischen älterem und jüngerem Studienkollektiv, wie auch zwischen Gestürzten und nicht Gestürzten. Der gebildete Score basiert auf Bewegungsdaten, die außerhalb spezieller
Ganglabore erhoben wurden, kann die Detektion von sturzrisikogefährdeten Heimbewohnern erleichtern und nun in prospektiven Studien weiter etabliert werden.
Arterial and Venous Thromboembolic Complications in 832 Patients with BCR-ABL-Negative Myeloproliferative Neoplasms
Authors: Wille Kai , Deventer Eva , Sadjadian Parvis , Becker Tatjana , Kolatzki Vera , Hünerbein Karlo , Meixner Raphael , Jiménez-Muñoz Marina , Fuchs Christiane , Griesshammer Martin 
Published: October 2023

AbstractArterial (ATE) and venous (VTE) thromboembolic complications are common causes of morbidity and mortality in BCR-ABL-negative myeloproliferative neoplasms (MPNs). However, there are few studies that include all MPN subtypes and focus on both MPN-associated ATE and VTE. In our single-center retrospective study of 832 MPN patients, a total of 180 first thromboembolic events occurred during a median follow-up of 6.6 years (range: 0–37.6 years), of which 105 were VTE and 75 were ATE. The probability of a vascular event at the end of the follow-up period was 36.2%, and the incidence rate for all first ATE/VTE was 2.43% patient/year. The most frequent VTE localizations were deep vein thrombosis with or without pulmonary embolism (incidence rate: 0.59% patient/year), while strokes were the most frequent ATE with an incidence rate of 0.32% patient/year. When comparing the group of patients with ATE/VTE (n = 180) and the group without such an event (n = 652) using multivariate Cox regression analyses, patients with polycythemia vera (hazard ratio [HR]: 1.660; [95% confidence interval [CI] 1.206, 2.286]) had a significantly higher risk of a thromboembolic event than the other MPN subtypes. In contrast, patients with a CALR mutation had a significantly lower risk of thromboembolism compared with JAK2-mutated MPN patients (HR: 0.346; [95% CI: 0.172, 0.699]). In summary, a high incidence of MPN-associated VTE and ATE was observed in our retrospective study. While PV patients or generally JAK2-mutated MPN patients had a significantly increased risk of such vascular events, this risk was reduced in CALR-mutated MPN patients.
Demenzdiagnosen in deutschen Hausarztpraxen – Ein Vergleich
mit der Prävalenzschätzung für das Jahr
2021
Authors: Bohlken Jens , Riedel-Heller Steffi G. , Kostev Karel , Michalowsky Bernhard 
Published: October 2023

Zusammenfassung
Hintergrund Nach einer aktuellen Prävalenzschätzung aus
2021 leben 1,8 Mio. Menschen mit Demenz (MmD) in Deutschland. Diese
Schätzungen basieren auf Feldstudien und bilden nicht das
Diagnosegeschehen der ärztlichen Versorgung ab. Analyseziel war daher
die Prävalenz sowie die Altersverteilung der MmD in Hausarztpraxen (HA)
mit der Prävalenzschätzung zu vergleichen.
Methode Vergleich der 2021 diagnostizierten MmD in 946 HA-Praxen mit
über 2,8 Mio. Patienten mit der aktuellen
Prävalenzschätzung der Deutschen Alzheimer Gesellschaft
für 83 Mio. Einwohner in Deutschland.
Ergebnisse In HA-Praxen werden im Vergleich zur
Prävalenzschätzung seltener Demenzen dokumentiert (1,88%
vs. 2,16%), insbesondere in den Altersgruppe 80 Jahre und älter
betragen die prozentualen Prävalenzunterschiede mehr als 4%.
Diskussion Es bestehen weiterhin Verbesserungspotentiale bei der
Demenzdiagnostik, insbesondere bei den über 80-jährigen MmD.
Molybdenum-Catalyzed Directed Activation of Aryl Chlorides and Fluorides
Authors: Asako Sobi , Ilies Laurean , Banerjee Somsuvra , Matsushita Naoki , Nakamura Eiichi , Patil Nitin T. 
Published: October 2023

AbstractA low-valent molybdenum species generated by the reduction of a molybdenum precursor with phenylmagnesium bromide catalytically cleaves a C–Cl or C–F bond in an aromatic ketone under mild conditions, followed by cyclization to produce a hydroxyphthalan (1,3-dihydro-2-benzofuran-1-ol) derivative.
What a Neurosurgeon Should Know about the Endolymphatic Sac: Part 1–Anatomy and Physiology
Authors: Vaz Marco Antônio Schlindwein , Monteiro Jander , Braga Francisco Luiz Souza , Lavinsky Joel , Santis Giuseppe Casella , Becker Lia Grub , Rocha Filho Marcelo Assis Moro da , Ribas Carmen Austrália Paredes Marcondes , Araújo Ricardo Marques Lopes de , Figueiredo Eberval Gadelha , Isolan Gustavo Rassier 
Published: October 2023

Abstract
Objective To describe the microsurgical anatomy and the physiology of the endolymphatic sac (ES) that a neurosurgeon should know.
Methods Review of previous studies from 1927 to 2021, from basic and translational research using human and animal ES tissue or cells, as well as previous reviews about the subject. The present article is divided into three parts. In this first part, we review the microsurgical anatomy and physiology of the ES.
Results The ES is a structure situated in the inner ear, together with the cochlea, the vestibular system, and other structures. Differently from its adjacent structures, the ES does not have a specialized epithelium; instead, it has mitochondria-rich cells and ribosomal-rich cells, which are responsible for ionic transportation and secretory activity. Apart from these functions, the ES is also responsible for homeostasis regulation of the inner ear, endolymphatic fluid volume control, immune response, elimination of inner ear cellular debris and floating otoconia, regulation of membranous labyrinth pressure, acid/basic transport, and secretion of substances. Its anatomy is not very variable, since in most studies no more than 20mm separates the location of the ES in the samples, in any direction.
Conclusion The human ES has vital functions in the inner ear, and its anatomy is rarely variable. Knowing that, and the importance of this area for neurosurgery, the present study elucidates the exact location of the ES and the lost functions that a lesion in this structure must cause.