bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poursuivre le plaisir de penser ensemble : logique gestionnaire et legs coloniaux au Brésil
Authors: Lafraia Luciana , Castanho Pablo 
Published: December 2023

Cet article témoigne du « plaisir de penser ensemble » à partir de la collaboration scientifique établie ces dernières années entre Jean-Pierre Pinel et l’Université de São Paulo, notamment au sein du groupe de recherche « Clinique de groupe et institutions : approche psychanalytique » ( cligiap ). Nous débuterons par une brève synthèse des activités développées à l’Université dans le cadre de cette collaboration, et par la référence aux travaux du groupe adossés de façon fondamentale à ces apports. Nous poursuivrons en relatant l’expérience du penser ensemble, en son absence. Les auteurs souligneront quelques contributions de Jean-Pierre Pinel autour des menaces qui pèsent sur les fonctions intermédiaires dans notre hypermodernité, et leurs incidences sur les équipes soignantes. Ceci interroge les spécificités de la réalité sociopolitique et institutionnelle brésilienne, notamment son héritage colonial toujours actif. Le plaisir de penser ensemble ainsi que la capacité de rêverie partagée des équipes constituent des sources de créativité et de résistance face aux mouvements de déliaison et de désubjectivation.
Les institutions d’accueil des mineurs isolés : un site pour ressaisir et élaborer les répercussions subjectives des effondrements et des ruptures des cadres culturels
Authors: Pinel Jean-Pierre 
Published: December 2023

Ce texte, inédit en français, est la transcription d’une communication prononcée par Jean-Pierre Pinel à Ischia, en 2018, lors des journée scientifiques de l’Association européenne pour l’analyse transculturelle de groupe. Adossé à une vignette clinique principale, l’auteur y déploie de manière originale le concept de répondant, tantôt indisponible, refusé, défaillant, et les effets psychiques mais aussi institutionnels, notamment de retournement, pour les adolescents comme pour les professionnels confrontés à une telle « déprivation du répondant ». À partir de ces conceptions, s’opère un renouvèlement des problématiques de la transmission entre générations au sein de cadres culturels complexes et invitent à comprendre les adolescents (et la clinique afférente) comme des « révélateurs et portes symptômes » susceptibles de nous permettre de nous « ressaisir des répercussions subjectives liées à l’empilement des catastrophes collectives qui ont jalonné le xx e et le xxi e siècle ».
Violence mortifère, destructrice, et violence créatrice, au service de la vie
Authors: Kaës René , Pinel Jean-Pierre 
Published: December 2023

Ce texte est la transcription d’un extrait des plus saillants d’un entretien de René Kaës mené par Jean-Pierre Pinel à l’occasion du colloque de la Fédération française des psychologues et de psychologie « Aux sources de la violence : de l’enfance à l’adolescence » qui s’est tenu à Paris en octobre 2009. À l’invitation de Jean-Pierre Pinel, René Kaës y développe quelques aspects d’une « théorie de la violence et de la négativité » et simultanément d’une « violence au service de la vie ». Soutenu par les apports de nombreux auteurs (Anzieu, Aulagnier, Bergeret, Zaltzman, Gibello, Puget…), René Kaës dresse progressivement les lignes de force d’un processus de symbolisation de la violence qui ne serait pas uniquement représentation de l’origine mais bien représentation de la violence des origines.
The Teleost CXCL13–CXCR5 Axis Induces Inflammatory Cytokine Expression through the Akt–NF-κB, p38–AP-1, and p38–NF-κB Pathways
Authors: Ding Chunhua , Xiao Tiaoyi , Deng Yadong , Yang Hong , Xu Baohong , Li Junhua , Lv Zhao 
Published: December 2023

Abstract
The ancestors of chemokines originate in the most primitive of vertebrates, which has recently attracted great interest in the immune functions and the underlying mechanisms of fish chemokines. In the current study, we identified an evolutionarily conserved chemokine, CiCXCL13, from a teleost fish, grass carp. CiCXCL13 was characterized by a typical SCY (small cytokine CXC) domain and four cysteine residues (C34, C36, C61, C77), with the first two cysteines separated by a random amino acid residue, although it shared 24.2–54.8% identity with the counterparts from other vertebrates. CiCXCL13 was an inducible chemokine, whose expression was significantly upregulated in the immune tissues of grass carps after grass carp reovirus infection. CiCXCL13 could bind to the membrane of grass carp head kidney leukocytes and promote cell migration, NO release, and the expression of &gt;15 inflammatory cytokines, including IL-1β, TNF-α, IL-10 and TGF-β1, thus regulating the inflammatory response. Mechanistically, CiCXCL13 interacted with its evolutionarily conserved receptor CiCXCR5 and activated the Akt–NF-κB and p38–AP-1 pathways, as well as a previously unrevealed p38–NF-κB pathway, to efficiently induce inflammatory cytokine expression, which was distinct from that reported in mammals. Zebrafish CXCL13 induced inflammatory cytokine expression through Akt, p38, NF-κB, and AP-1 as CiCXCL13. Meanwhile, the CiCXCL13–CiCXCR5 axis–mediated inflammatory activity was negatively shaped by grass carp atypical chemokine receptor 2 (CiACKR2). The present study is, to our knowledge, the first to comprehensively define the immune function of CXCL13 in inflammatory regulation and the underlying mechanism in teleosts, and it provides a valuable perspective on the evolution and biology of fish chemokines.
Student Competition (Technology Innovation) ID 1970388
Authors: Dousty Mehdy , Fleet David J. , Zariffa José 
Published: December 2023

Background
The evaluation of hand function after spinal cord injury (SCI) is conducted in clinical settings, which may not accurately reflect hand function in the real world, thereby limiting the efficacy assessment of new treatments. Wearable cameras, also known as egocentric video, are a novel method to evaluate hand function in non-clinical environments. Nonetheless, manual processing of vast quantities of complex video data is difficult, highlighting the need for automated data analysis. The objective of this study was to automatically identify distinct hand postures in egocentric video using unsupervised machine learning.

Methods
Seventeen participants with cervical SCI recorded activities of daily living in a home simulation laboratory. A hand pose estimation algorithm was applied on detected hands to determine 2D joint locations, which were lifted to 3D coordinates. The resulting hand posture information was subjected to a number of clustering techniques. Hand grasps were manually labelled into four categories for evaluation purposes: power, precision, intermediate, and non-prehensile.

Results
K-Means clustering consistently exhibited the highest Silhouette score, which reflects the presence of discrete clusters in the data. When comparing with manual annotations, Spectral Clustering applied to a feature space consisting of 2D pose estimation with confidence scores yield the best performance as quantified by maximum match (0.48), Fowlkes-Mallows score (0.46), and normalized mutual information (0.22).

Conclusions
This is the first attempt to develop an unsupervised, data-driven hand taxonomy for individuals with SCI using wearable technology. The findings suggest that the method is capable of grouping similar hand grasps.
Student Competition (Knowledge Generation) ID 1975184
Authors: Kaiser Anita , Chan Katherine , Sessford James , McCullum Shane , Athanasopoulos Peter , Rice Chris , MacRitchie Iona , Zariffa José , Musselman Kristin E. 
Published: December 2023

Background/Objectives
Implementing activity-based therapy (ABT) across the continuum of care in Canada has proved challenging. The objective of this study was to understand and compare multi-group perspectives on the challenges that hinder implementation of ABT in Canada for people living with spinal cord injury or disease (SCI/D).

Methods
Individuals from six key interest groups (i.e., researchers; persons living with SCI/D; administrators; physical and occupational therapists; community-based exercise trainers; and funders, advocates, and policy experts) who had knowledge of and/or experience with ABT were recruited to participate in focus group interviews that were held over web conferencing. Participants were asked about the barriers and facilitators to practicing ABT. Interview transcripts were analyzed using conventional content analysis followed by a comparative analysis across groups.

Results
Forty-eight individuals participated in interviews lasting 30-80 minutes. Six themes were identified: 1) Challenge of defining ABT and addressing gaps in knowledge/training. 2) Challenge of standardizing ABT. 3) Challenge of determining the optimal timing of ABT. 4) Challenge of defining, characterizing and achieving high dosage and intensity. 5) Challenge of funding ABT. 6) Challenge of measuring participation and performance in ABT. While all groups acknowledged these six challenges, therapists and community trainers viewed knowledge/training gaps and achieving high dosage and intensity as key challenges. Researchers and advocates emphasized funding as a key challenge.

Conclusion
Participants highlighted the challenges that limit adoption of ABT into practice within hospital and community settings. Future research should explore avenues to address these challenges to support successful implementation of ABT in Canada.
Poster (Health Services, Economics and Policy Change) ID 1977284
Authors: Chan Brian , Lam Natascha , Rafael Verena , Pakosh Maureen , Musselman Kristin 
Published: December 2023

Background/Objective
Activity-based therapies (ABT) are task specific, repetitive and intensive active movement interventions that may improve function and independence for individuals with spinal cord injury. The cost of implementing ABT is an important consideration for rehabilitation facilities interested in providing this intervention. Thus, a scoping review was conducted to evaluate the economic evidence for ABT for the rehabilitation of upper or lower limb impairment.

Design/Methods
A search of various scientific literature databases (including EMBASE, MEDLINE and CINAHL) was conducted using search terms developed in collaboration with a Medical Librarian. Studies were included if they were economic analyses of an ABT conducted for individuals with upper or lower limb mobility impairment. Titles and abstracts were initially screened by two of the authors followed by a full-text review of remaining articles. Articles included in the review were evaluated for methodological quality and presented descriptively because of the heterogeneity in study design, populations and outcomes.

Results
Of the 6,031 unique citations originally identified, 14 articles were included after full-text screening. Two-third of the studies were for stroke and half of the studies originated from the US. Robot-assisted therapies represented half of the studies and about a quarter were locomotor training programs. In the stroke and spinal cord injured population, robot-assisted therapies and body supported treadmill therapy appear to be cost-effective respectively.

Conclusions
There is some evidence to support the cost-effectiveness of robot-assisted therapies and body supported treadmill therapy. However, the evidence is very limited and additional research is needed.
Poster (Clinical/Best Practice Implementation) ID 1981325
Authors: Oldford Laura M. , Casey Lauren E. , Campbell Samuel , McCullum Shane A. , de Passillé Erica J. , O’Connell Colleen M. 
Published: December 2023

Background
Many barriers prevent those with spinal cord injury or disease (SCI/D) from adhering to recommended exercise guidelines, thus increasing risks of secondary health conditions. Mainstream technology options, such as virtual reality (VR), have the potential to facilitate needed exercise participation. However, further research on VR exercise modalities is needed to determine feasibility, effectiveness and to ultimately guide practice recommendations.

Objectives
The goal of this pilot feasibility study was to determine whether VR exergaming is non-inferior to the current standard of care (SoC) upper extremity aerobic exercise for individuals with SCI/D.

Methods/Overview
25 participants with SCI/D completed 10-minute exercise sessions with either VR or the SoC, and after a rest break, then completed 10 minutes of exercise with the other modality. Primary outcomes of heart rate (HR) and rate of perceived exertion (RPE) were collected at baseline, 5 minutes into exercise, and at 10 min (end of the exercise session) for each modality. Secondary exploratory measures included a Numeric Pain Rating Scale measured pre- and post- each exercise session, and a post-study likeability survey.

Results
There were no significant differences in HR or RPE between virtual reality exergaming and the standard of care, and 100% of participants preferred the VR over SoC for the exercise.

Conclusions
VR exergaming was non-inferior to the SoC for short duration upper extremity exercise in those with SCI/D. Implementing VR for patients with SCI/D should be studied further to observe the longer term effect on cardiovascular health and to determine feasibility and compliance for home use.
Student Competition (Knowledge Generation) ID 1985151
Authors: Cadel Lauren , Cimino Stephanie R , Bradley-Ridout Glyneva , Hitzig Sander L , Packer Tanya L , McCarthy Lisa M , Patel Tejal , Lofters Aisha K , Hahn-Goldberg Shoshana , Ho Chester H , Guilcher Sara JT 
Published: December 2023

Background
Persons with traumatic spinal cord injury (SCI) are often experience polypharmacy, the use of multiple medications, to manage secondary complications and concurrent conditions. Despite the prevalence of polypharmacy and challenges associated with managing medications, there are few tools to support persons with SCI with medication self-management.

Objective
The purpose of this scoping review was to identify and summarize what is reported in the literature on medication self-management interventions for adults with traumatic SCI.

Methods
Articles were searched on electronic databases and grey literature. For inclusion, articles were required to include an adult population with a traumatic SCI and an intervention targeting medication management. They had to incorporate a component of self-management. Articles were independently screened and data were extracted and synthesized using descriptive approaches.

Findings
Three studies were included in this scoping review. Interventions included a mobile app and two education-based interventions to address self-management of SCI, medication management, and pain management. None of the identified interventions addressed medication self-management comprehensively. Learning outcomes (perceived knowledge and confidence), behavioural outcomes (management strategies, data entry), and clinical outcomes (number of medications, pain scores, functional outcomes) were evaluated. Results of the interventions varied, but some positive outcomes were noted, with improvements in perceived knowledge and confidence and a reduction in the use of multiple pain medications.

Conclusion
Overall, there are limited interventions targeting medication self-management for persons with SCI. There is an opportunity better support this population through the co-design and implementation of an intervention that comprehensively addresses self-management.
Student Competition (Knowledge Generation) ID 1985158
Authors: O’Sullivan Carly L. , Tyreman Neil , Shanti Rofyontsa F. , O’Steen Wilbur A. , Mirkiani Soroush , Boakye Maxwell , Howland Dena R. , Mushahwar Vivian K. 
Published: December 2023

Background
Spinal cord injury (SCI) affects locomotion and quality of life. Two spinal cord stimulation approaches are currently under investigation for restoring standing and walking following SCI: epidural spinal cord stimulation (ESCS) and intraspinal microstimulation (ISMS). In ESCS, electrodes are placed on the dura mater and in ISMS, ultrafine wires are inserted into the cord. These modalities likely activate the locomotor regions in the ventral horn through different pathways.

Objective
The goal of this study is to examine the difference in the distribution of neuronal activation and the type of neurons activated by ESCS and ISMS.

Methods
The first step was to establish the needed immunohistochemical (IHC) staining protocols. Domestic pigs were divided into naïve (n=2) and positive control (n=1) groups. The naïve control animals were anesthetized for 5 hrs. The positive control animal was anesthetized for 2 hrs and injected with hypertonic saline in hindlimb muscles. The animals were then euthanized, and the spinal cord removed for IHC analysis. Antibodies against cFos, a maker of neuronal activation, and NeuN, a neuronal marker were used.

Results
Preliminary results indicate that ESCS activates neurons in the dorsal horn with scattered activation in the intermediate and ventral regions. ISMS primarily activates neurons in the intermediate and ventral regions where locomotor-related networks reside.

Significance
To the best of our knowledge, this is the first time the type and sites of activation of ESCS and ISMS are investigated. This will provide a foundational understanding of the mechanism of action of these stimulation modalities.
Poster (Knowledge Generation) ID 1985172
Authors: Seliman Merna , Hong Julianne , Marrocco Stephanie , Lo Erica , Walden Kristen , Chase Andrea , Lemay Jean François , Donkers Sarah , Wolfe Dalton L. 
Published: December 2023

Background
Rehabilitation approaches after Spinal Cord Injury (SCI) differ across rehabilitation centres and between therapists. Differences may be influenced by factors such as therapeutic approaches, equipment availability, training provided for therapists, or demographics of admitted patients. A measure of physical function that is widely used within Canadian rehabilitation centres is the Standing and Walking Assessment Tool (SWAT). It is not clear what factors or therapeutic approaches lead to optimal standing and walking outcomes in the SCI population.

Objectives
To explore the perspectives of physio-therapists on factors that affect standing and walking outcomes in inpatient SCI rehabilitation.

Methods
Three focus groups were conducted with nine physiotherapists representing seven inpatient rehabilitation centres across Canada to provide their perspectives on current practices and to gain in-depth insights into centre-specific factors that may influence standing and walking outcomes. Thematic analysis was used to analyze the focus group data.

Results
Thematic analysis revealed that high treatment intensity and frequency are needed for optimal standing and walking outcomes. Physiotherapists emphasized that appropriate length of stay was essential to deliver an effective treatment plan. They noted, however, that there is pressure to discharge patients quickly leading to shorter length of stays and a perceived compromise in outcomes. Physiotherapists emphasized the importance of building rapport with patients, creating an exciting therapeutic environment, and the availability of enough staff for optimal recovery.

Conclusions
The findings of this qualitative study will inform the implementation and development of opportunities to optimize standing and walking outcomes across rehabilitation centres in Canada.
Post-Doc Competition (Knowledge Generation) ID 1985177
Authors: Tsang Philemon , Souza Wagner H , Walden Thomas , Miyatani Masae , Craven Cathy 
Published: December 2023

Background
Heart Disease is the leading cause of death after spinal cord injury (SCI). Individuals with paraplegia develop hypertension and elevated arterial stiffness prior to their age matched peers. Overground exoskeleton training is becoming an increasingly prevalent form of exercise. In the general population, exercise training has been shown to reduce arterial stiffness. Recent RCT failed to show changes in arterial stiffness with arm ergometry or body weight supported treadmill training.

Objectives
The aim of this project is to determine the effect of Exoskeleton Exercise on changing arterial stiffness.

Study Design
The study setting will take place at a rehabilitation facility. The study will involve 34 sessions over the span of approximately 18-20 weeks. The key intervention utilized in the investigation will be an Overground EksoNR gait and balance training program. The primary outcome measure will be carotid-femoral pulse wave velocity (cfPWV) and secondary measures will include heart rate (HR), blood pressure (BP), waist circumference (WC), and oxygen saturation (SpO2). Statistical Analysis will involve mean changes at baseline, midway, and end of study.

Methods
The 34-session (2x/week for ∼18 weeks) rehabilitation protocol will focus on using the EksoNR for overground gait and balance activities. For measurement of cfPWV, two transcutaneous Doppler flowmeters will be used at the common carotid and femoral artery. To calculate cfPWV, the distance travelled by the pulse is divided by the average pulse transit time (PTT).

Hypothesis
The 18-week Exoskeleton Program would improve arterial stiffness (cfPWV) in individuals with chronic incomplete SCI/D.
Student Competition (Knowledge Generation) ID 1985185
Authors: Hemakumara Sisuri G. , Karamzadeh Zahra , Mann Darren J. , Barss Trevor S. , Mushahwar Vivian K. 
Published: December 2023

Background/Objective
Transcutaneous spinal cord stimulation (tSCS) facilitates spinal networks involving motor function. The purpose of this study is to compare the effect of stimulators used and amplitude of tSCS, applied at the cervical region of the spinal cord, on propriospinal modulation of lower limbs. Corticospinal and spinal reflex excitability were assessed with lower limb motor evoked potentials (MEPs), and Hoffman (H-) reflexes, respectively.

Methods
Neurologically intact participants (n=6) were recruited. Two stimulators (NeoStim-5 and DS8R) were used, and different tSCS amplitudes at threshold (thresh) and maximum tolerance (max) were applied. The effect of tSCS on the amplitude of the H-reflex evoked in the soleus muscle was assessed, as well as the effect of cervical tSCS on MEPs evoked in the tibialis anterior muscle. Participants completed five conditions including: 1) Control (no stimulation) 2) DS8R Thresh 3) DS8R Max 4) NeoStim-5 Thresh 5) NeoStim-5 Max.

Results
At the same tSCS amplitude, the participants subjectively tolerated the NeoStim-5 better than the DS8R. The maximum tolerated amplitude for NeoStim-5 was higher than that of the DS8R, for all participants. Preliminary analysis suggests changes in tSCS amplitude delivered, do not appear to have an effect on the H-reflex and MEP in this small sample of participants.

Conclusions
Preliminary findings indicate that different stimulators produce different sensations at the same tSCS amplitudes. Changes in stimulator amplitudes do not appear to have an effect on the electrophysiological outcome on propriospinal modulation. This study sets the basis for understanding mechanisms of tSCS, including cutaneous activation.