bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between meeting the 24‐h movement guidelines and psychosocial health in children: A cross‐sectional study
Authors: Bao Ran , Yang Zhen , Memon Aamir Raoof , Chen Sitong , Wang Lei , Cai Yujun 
Published: October 2023

AbstractObjectiveEmerging evidence suggests that meeting the 24‐h movement guidelines is associated with optimal mental health. However, there remains some uncertainty regarding this association in children. Therefore, this study aimed to examine the association between meeting the 24‐h movement guidelines and psychosocial health in children.MethodsA cross‐sectional study design was employed to investigate 2005 children aged 9–12 years from four districts of Shanghai, China. The 24‐h movement behaviours were assessed using selected items from the Health Behaviour in School‐aged Children (HBSC) survey questionnaire. Children's self‐rated psychosocial health was evaluated using the Strengths or Difficulties Questionnaire (SDQ). Generalised Linear Models with the ordinal logistic module were employed to analyse the association between meeting the 24‐h movement guidelines and psychosocial health.ResultsThe overall prevalence of meeting all three 24‐h movement recommendations was 10.2%. Among children, 7.9% of them exhibited abnormal total difficulties, with a notable difference between sex (boys: 11.2%, girls: 7.0%, p = 0.001). Meeting all three 24‐h movement behaviour recommendations was associated with reduced total difficulties, emotional symptoms, conduct problems, hyperactivity and peer problems. Furthermore, a dose–response association was observed, indicating that meeting a greater number of 24‐h movement behaviour recommendations was associated with enhanced psychosocial health, particularly in boys.ConclusionThe findings of this study highlight the positive association between meeting the 24‐h movement guidelines and psychosocial health in children. Notably, meeting more of these recommendations was associated with a lower likelihood of experiencing psychosocial problems, with greater benefits observed in boys compared with girls.
The politics of care and confinement: Disabled people's affective lives during COVID‐19
Authors: Loughnane Cliona , Edwards Claire 
Published: October 2023

AbstractThis paper explores the affective and material impacts of the reconfiguration of caring on disabled people's lives during the pandemic. We draw on a series of focus groups and interviews with a group of nine disabled people with mobility or sensory impairments, many of whom were politically active in the arena of disability rights and independent living. This work forms part of a wider project re‐imagining care practices and policies. We reveal the interplay of emotion, affect and socio‐material conditions in disabled people's pandemic lives and reflect on how pre‐existing diminished care landscapes compounded COVID‐19's impacts. With support services shuttered and people confined at home, many disabled people experienced a renewed dependence on family care or found their care needs reduced to functional tasks undertaken by rota‐filling workers. We document participants' emotional experiences of loss, fear and anger deriving from changes in their one‐to‐one care interactions and arrangements but also wider societal narratives positioning disabled people as both vulnerable to, and carriers of, disease. Drawing together the crisis' affective and material effects, we demonstrate how disabled people politicized their affective experiences of anger and hope through online organizing to challenge the diminution of supports and demand affective justice from the care system.
Expression and metabolism profiles of CVT associated with inflammatory responses and oxygen carrier ability in the brain
Authors: Kui Ling , Jiao Yinming , Jiang Huimin , Wang Guoyun , Li Zongyu , Ji Xunming , Zhou Chen 
Published: October 2023

AbstractAimAs the main type of stroke, the incidence of cerebral venous thrombosis (CVT) has been rising. However, the comprehensive mechanisms behind it remain unclear. Thus, the multi‐omics study is required to investigate the mechanism after CVT and elucidate the characteristic pathology of venous stroke and arterial stroke.MethodsAdult rats were subjected to CVT and MCAO models. Whole‐transcriptome sequencing (RNA‐seq) and untargeted metabolomics analysis were performed to construct the transcriptome and metabolism profiles of rat brains after CVT and also MCAO. The difference analysis, functional annotation, and enrichment analysis were also performed.ResultsThrough RNA‐seq analysis, differentially expressed genes (DEGs) were screened. 174 CVT specific genes including Il1a, Ccl9, Cxxl6, Tnfrsf14, etc., were detected. The hemoglobin genes, including both Hba and Hbb, were significantly downregulated after CVT, compared both to the MCAO and Sham groups. Metabolism analysis showed that CVT had higher heterogeneity of metabolism compared to MCAO. Metabolites including N‐stearoyltyrosine, 5‐methoxy‐3‐indoleaceate, Afegostat, pipecolic acid, etc. were specially regulated in CVT. Through the immune infiltration analysis, it was found that CVT had a higher immune response, with the abundance of certain types of immune cells increased, especially T helper cells. It was important to find the prevalence of the activation of inflammatory chemokine, cytokine, NOD‐like pathway, and neutrophil extracellular trap.ConclusionWe explored and analyzed the gene expression and metabolomic characteristics of CVT, revealed the specific inflammatory reaction mechanism of CVT and found the markers in transcriptome and metabolism levels. It points out the direction for CVT early diagnosis and treatment.
Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis
Authors: Li Jun , Wang Liya , Yin Suqing , Yu Shuangshuang , Zhou Yanyu , Lin Xiaoqi , Jiao Yingfu , Yu Weifeng , Xia Xiaoqiong , Yang Liqun , Gao Po 
Published: October 2023

AbstractAimsItch, a common uncomfortable sensory experience, occurs frequently in inflammatory or allergic disorders. In recent years, with the discovery of itch‐specific pathways in the peripheral and central nervous system, the association between immunology and neural pathways has gradually emerged as the main mechanism of itch. Although many studies have been conducted on itch, no bibliometric analysis study focusing on this topic has been conducted. This study aimed to explore the research hotspots and trends in the itch field from a bibliometric perspective.MethodsPublications relevant to itch, published from 2003 to 2022, were retrieved from the Science Citation Index‐Expanded of Web of Science Core Collection. Publications were critically reviewed and analyzed with CiteSpace software, Vosviewer, and the bibliometric online analysis platform. Visual maps were conducted in terms of annual production, collaborating countries or institutions, productive authors, core journals, co‐cited references, and keyword bursts.Results2395 articles on itch that met our criteria were identified and the quantity of publications has been increasing rapidly since 2012. The USA was the most influential country. University Hospital Münster was the institution with the most publications. Gil Yosipovitch was the most prolific author. Atopic dermatitis (AD), intradermal serotonin, chronic pruritus, mechanical itch, gastrin‐releasing peptide, substance p, interleukin‐31 receptor, histamine‐induced itch, bile acid, scratching behavior, and h‐4 receptor were the top 11 clusters in co‐citation cluster analysis. Keyword burst analysis suggested that treatment, inflammation, and AD are current research hotspots.ConclusionGlobal publications on itch research have increased steadily and rapidly over the past 20 years. Inflammation and AD are current research hotspots. The neuroimmunological and neuroinflammatory mechanisms of itch, as well as clinical assessment methods and therapeutic targets, will be novel research directions in the future. This study provides guidance for further itch research.
Enhanced interleukin‐6 in human adipose tissue vein after sprint exercise: Results from a pilot study
Authors: Esbjörnsson Mona , Norman Barbara , Persson Moa , Saini Amarjit , Bülow Jens , Jansson Eva 
Published: October 2023

AbstractBackgroundLow‐volume sprint exercise is likely to reduce body fat. Interleukin (IL‐6) may mediate this by increasing adipose tissue (AT) lipolysis. Therefore, the exchange of AT IL‐6 and glycerol, a marker of lipolysis, was examined in 10 healthy subjects performing three 30‐s all‐out sprints.MethodsBlood samples were obtained from brachial artery (a) and a superficial subcutaneous vein (v) on the anterior abdominal wall up to 9 min after the last sprint and analysed for IL‐6 and glycerol.ResultsArterial IL‐6 increased 2‐fold from rest to last sprint. AT venous IL‐6 increased 15‐fold from 0.4 ± 0.4 at rest to 7.0 ± 4 pg × mL−1 (p < 0.0001) and AT v–a difference increased 45‐fold from 0.12 ± 0.3 to 6.0 ± 5 pg x mL−1 (p < 0.0001) 9 min after last sprint. Arterial glycerol increased 2.5‐fold from rest to 9 min postsprint 1 (p < 0.0001) and was maintained during the exercise period. AT venous and v–a difference of glycerol increased 2‐fold from rest to 9 min postsprint 1 (p < 0.0001 and p = 0.01, respectively), decreased until 18 min postsprint 2 (p < 0.001 and p < 0.0001), and then increased again until 9 min after last sprint (both p < 0.01).ConclusionsThe concurrent increase in venous IL‐6 and glycerol in AT after last sprint is consistent with an IL‐6 induced lipolysis in AT. Glycerol data also indicated an initial increase in lipolysis after sprint 1 that was unrelated to IL‐6. Increased IL‐6 in adipose tissue may, therefore, complement other sprint exercise‐induced lipolytic agents.
The U.S. needs a National Biodiversity Strategy
Authors: Gerber Leah R. , Schwartz Mark W. , Dreiss Lindsay M. 
Published: October 2023

AbstractThe U.S. needs a National Biodiversity Strategy (hereafter Strategy). As a nation that places a high value on domestic biodiversity and on being a global leader in biodiversity conservation, the U.S. is failing to live up to its expectations regarding a national Strategy. A Strategy should suggest both legislation and policies and guide our country toward achieving stated objectives. We first propose a process to create a Strategy that involves establishing a government task force and supporting expert advisory panel. We then identify five key elements of a Strategy. First, a Strategy should identify priorities among legislation that impacts biodiversity. At present, conflicting rules lead to administrative uncertainty and inconsistent decisions. Second, a Strategy should create a comprehensive vision for societal participation in biodiversity protection. Current practices comprise a mixture of different levels of commitment to stakeholder participation and social justice. Third, a Strategy should mandate periodic review to better provide the American public a synopsis of how we are faring with our treasured biodiversity. Fourth, a Strategy should be as comprehensive and broad as biodiversity itself, spanning organizational ranges from genes to ecosystems. Finally, a Strategy should provide a structure for achievement that incentivizes public and business and that stimulates innovation, particularly in nature‐based solutions to complex environmental challenges.
Pilot study on anti‐reflux mucoplasty: Advancing endoscopic anti‐reflux therapy for gastroesophageal reflux disease
Authors: Inoue Haruhiro , Yamamoto Kazuki , Shimamura Yuto , Azuma Daisuke , Ushikubo Kei , Okada Hiroki , Kimoto Yoshiaki , Nishikawa Yohei , Tanaka Ippei , Tanabe Mayo , Onimaru Manabu , Navarro Marc Julius 
Published: October 2023

ObjectivesAnti‐reflux mucosectomy (ARMS) and anti‐reflux mucosal ablation (ARMA) were developed as interventions for proton pump inhibitor (PPI)‐refractory/‐dependent gastroesophageal reflux disease (GERD). Although ARMS and ARMA are established treatments for PPI‐refractory GERD, reliance on natural healing for ulcer scar formation introduces uncertainty and bleeding risk. To address these issues, we introduced a novel approach called anti‐reflux mucoplasty (ARM‐P), which involves immediate closure of mucosal defects following mucosectomy. This pilot study aims to evaluate the safety, feasibility, and efficacy of ARM‐P.MethodsA retrospective single‐center study was conducted using prospectively collected data from October 2022 to July 2023. Patients with PPI‐refractory/‐dependent GERD who underwent ARM‐P were included. The study evaluated technical success of ARM‐P, before and after ARM‐P GERD‐Health Related Quality of Life Questionnaire, GerdQ, and Frequency Scale for the Symptoms of GERD scores, along with PPI discontinuation and endoscopic esophagogastric junction morphology.ResultsA total of 20 patients with a median age of 61.5 years underwent the ARM‐P procedure. The procedure achieved 100% technical success without adverse events. After ARM‐P, 55.0% discontinued PPI usage and 15.0% reduced PPI dose by half. Median GERD‐Health Related Quality of Life Questionnaire score improved from 21 to 6 (P = 0.0026), median GerdQ score improved from 9 to 7 (P = 0.0022), and median Frequency Scale for the Symptoms of GERD score decreased from 16 to 7 (P = 0.0003). Median Hill's Classification significantly improved from grade III to grade I (P = 0.0001).ConclusionsThis study presents the first pilot report of ARM‐P, demonstrating its procedural safety, technical feasibility, and short‐term efficacy.
Recent advances in delivery of transdermal nutrients: A review
Authors: Fan Ling , Huang Jihong , Ma Sen 
Published: October 2023

AbstractNutrients provide vital functions in the body for sustained health, which have been shown to be related to the incidence, prevention and treatment of disease. However, limited bioavailability, loss of targeting specificity and the increased hepatic metabolism limit the utilization of nutrients. In this review, we highlight transdermal absorption of nutrients, which represents an opportunity to allow great use of many nutrients with promising human health benefits. Moreover, we describe how the various types of permeation enhancers are increasingly exploited for transdermal nutrient delivery. Chemical penetration enhancers, carrier systems and physical techniques for transdermal nutrient delivery are described, with a focus on combinatorial approaches. Although there are many carrier systems and physical techniques currently in development, with some tools currently in advanced clinical trials, relatively few products have achieved full translation to clinical practice. Challenges and further developments of these tools are discussed here in this review. This review will be useful to researchers interested in transdermal applications of permeation enhancers for the efficient delivery of nutrients, providing a reference for supporting the need to take more account of specific nutritional needs in specific states.
Factors influencing risk perception of inshore and offshore artisanal fishers in a marine protected area in Brazil
Authors: dos Santos Aline Olimpo , Oliveira Cicero Diogo L. , de Oliveira Junior José Gilmar C. , da Silva Batista Vandick 
Published: October 2023

AbstractArtisanal small‐scale fisheries are crucial for subsistence and food security, especially in developing countries. However, artisanal fishers face stressors, such as economic and social marginalization, conflicts, and overfishing. Socio‐economic attributes potentially influence their risk perception. We investigated risk perception among artisanal fishers in a Marine Protected Area through interviews and semi‐structured questionnaires. Risk perception was positively influenced by fishing environment and negatively influenced by a lack of religious beliefs. Offshore fishers faced more operating conditions and time at sea, with higher risk of losses, and perceived more health and conflict risks. Inshore fishers have higher perception of environmental degradation. Prioritizing different risk perceptions is essential for effective fisheries management. Separate management plans for offshore and inshore fisheries are recommended due to varying catch, environmental perception, socio‐environmental risks, and exploited resource characteristics among artisanal fisher groups.
A global comparative field study to evaluate the factor VIII activity of efanesoctocog alfa by one‐stage clotting and chromogenic substrate assays at clinical haemostasis laboratories
Authors: Pipe Steven , Sadeghi‐Khomami Ali , Konkle Barbara A. , Kitchen Steve , Negrier Claude , Liu Mingjie , Santagostino Elena , Willemze Annemieke , Abad‐Franch Lydia , Knobe Karin , Seth Chhabra Ekta 
Published: October 2023

AbstractIntroductionStructural and chemical modifications of factor VIII (FVIII) products may influence their behaviour in FVIII activity assays. Hence, it is important to assess the performance of FVIII products in these assays. Efanesoctocog alfa is a new class of FVIII replacement therapy designed to provide both high sustained factor activity levels and prolonged plasma half‐life.AimEvaluate the accuracy of measuring efanesoctocog alfa FVIII activity in one‐stage clotting assays (OSAs) and chromogenic substrate assays (CSAs).MethodsHuman plasma with no detectable FVIII activity was spiked with efanesoctocog alfa or a full‐length recombinant FVIII product comparator, octocog alfa, at nominal concentrations of 0.80 IU/mL, 0.20 IU/mL, or 0.05 IU/mL, based on labelled potency. Clinical haemostasis laboratories (N = 35) tested blinded samples using in‐house assays. Data from 51 OSAs (14 activated partial thromboplastin time [aPTT] reagents) and 42 CSAs (eight kits) were analyzed.ResultsEfanesoctocog alfa activity was reliably (±25% of nominal activity) measured across all concentrations using OSAs with Actin FSL and multiple other aPTT reagents. Under‐ and overestimation of FVIII activity occurred with some reagents. No specific trend was observed for any class of aPTT activators. A two‐ to three‐fold overestimation was consistently observed using CSAs and the OSA with Actin FS as the aPTT reagent across evaluated concentrations.ConclusionUnder‐ or overestimation occurred with some specific OSAs and most CSAs, which has been previously observed with other modified FVIII replacement products. Efanesoctocog alfa FVIII activity was measured with acceptable accuracy and reliability using several OSA methods and commercial plasma standards.
Speech acts and interaction in L2 pragmatics: Insights from Chinese as the target language
Authors: Ren Wei 
Published: October 2023

AbstractThe articles in this special issue contribute to second language (L2) pragmatics by investigating different speech acts and interactions in Chinese as the target language. The studies all examined learners’ pragmatic performance in different contexts and compared their performance with that of native Chinese speakers. The findings of the articles showed what the learners could achieve and what they still had problems in. In this commentary, I first analyze and discuss the aspects in these articles that impress me the most, including research design and focus on L2 pragmatics, theoretical contributions, and methodological considerations. Then, I will address some important implications that the articles provide for future research in L2 pragmatics.
Representation of the “business‐self”: Professionals’ construction of multifaceted identities in written business communication
Authors: Lee William Wai Lam 
Published: October 2023

AbstractThis study explores professionals’ construction of their multifaceted identities as representatives of their corporations in business writing. The self‐mention framework is applied to explore the representation of the “business‐self” which I propose encompasses the projection of individual, collective, and corporate identities. A corpus of 100 CEO's letter to shareholders was examined for the use of personal pronouns and company referential terms and collocation analysis performed to understand the surrounding discourse contexts. The findings reveal a distinct hierarchy of identities; US business professionals communicate with stakeholders by immersing themselves in the identity of the collective and make a concerted effort to project the corporate identity, whereas representation of the individual self is minimal. The study provides important insights into the identity construction work undertaken by professionals in authentic business texts and the findings can help inform English for Specific Purposes (ESP) practitioners of business communication courses in higher education.
Localized Pretibial Pemphigoid Associated with Trichilemmal Carcinoma
Authors: Nakatani Chie , Muramatsu Tsutomu , Shirai Toshihiko 
Published: October 2023

AbstractWe report a case of localized pretibial pemphigoid with concurrent trichilemmal carcinoma of the face in a 93‐year‐old woman. Immunoblot analysis showed circulating autoantibodies against the 230 kDa antigen. After removal of the skin tumor, the bullous skin lesions were reduced and healed with only the topical application of corticosteroid.
Purification and characterization of the constitutive form of laccase from the basidiomycete Coriolus hirsutus and effect of inducers on laccase synthesis
Authors: Koroljova‐Skorobogat'ko Olga V. , Stepanova Elena V. , Gavrilova Valeria P. , Morozova Olga V. , Lubimova Natalia V. , Dzchafarova Aida N. , Jaropolov Alexander I. , Makower Alexander 
Published: October 2023

An isolate of Coriolus hirsutus constitutively expresses substantial amounts of extracellular laccase on a defined growth medium. The most efficient inducer of extracellular laccase synthesis was syringaldazine, which increased the enzyme yield by 1000% at a concentration of 0·11 μM. The constitutive form of the enzyme was purified 312‐fold. Laccase from C. hirsutus, with an estimated molecular mass of 55 kDa and pI of 4·0, is a monomeric glycoprotein containing 12% carbohydrate consisting of mannose and N‐acetylglucosamine. The laccase was found to contain 3·9–4·1 copper atoms per molecule. The absorption spectrum shows a maximum at 610 nm and a shoulder at 330 nm, which is typical of laccase possessing type 1 and type 3 copper atoms. The parameters of the first type of copper were determined by EPR as g⊥=2·046 and g ∥=2·200, A∥ =8·103×10−3 cm−1. Laccase was found to be a pH‐stable and thermostable enzyme. With organic substrates it exhibits a pH optimum of 4·5, but with the inorganic substrate K4[Fe(CN)6] this decreased to 3·5. The highest efficiency of catalysis was observed with sinapinic acid as the substrate. The kinetic constants kcat and Km of this reaction were 578 s −1 and 24 μM respectively. It was established that the kinetics of the assayed reaction shows a Ping Pong mechanism.
RISK‐TAKING BEHAVIOR AND MANAGEMENT OWNERSHIP IN DEPOSITORY INSTITUTIONS
Authors: Chen Carl R. , Steiner Thomas L. , Whyte Ann Marie 
Published: October 2023

AbstractWe examine the relation between risk and ownership structure among depository institutions. The empirical results provide evidence that the relation between managerial ownership and depository institution risk is negative and significant, suggesting that as managerial ownership increases the level of risk‐taking decreases. This finding, which supports a risk aversion hypothesis, is consistent across several market‐based risk measures. Furthermore, we document greater risk and greater risk aversion for savings institutions relative to commercial banks.