bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can personal values moderate players’ affective states?
Authors: Castillo Isabel , Tomás Inés , Adell Francisco L. , Álvarez Octavio 
Published: January 2024

AbstractBased on self-determination theory and Schwartz’s refined theory of basic individual values, the aim of the study was to examine whether adolescents’ personal values might be moderating the relationship between coaches’ perceptions of interpersonal styles, and the affect they experience in relation to their basketball practice. A sample of 233 Spanish male basketball players between 13 and 14 years of age (M = 13.97, SD = 0.18) who were participating in a national competition were assessed. The Spanish versions of the Sport Climate Questionnaire (SCQ), the Controlling Coach Behaviors Scale (CCBS), the Portrait Values Questionnaire-Revised (PVQ-R) and the Positive and Negative Affect Scale (PANAS) were used to measure the variables of interest. Results reveal that for players who prioritize self-enhancement values, perceiving their coach as autonomy-supportive significantly reduces their negative affect. Moreover, prioritizing self-transcendence values neutralizes the positive effect of a controlling style on negative affect. This study highlights the relevance of identifying personal values in order to enhance positive affective states. Furthermore, it emphasizes the importance for coaches to work using more autonomy-supportive strategies and avoid working with the use of controlling behaviors to promote positive affect and to prevent negative affect in order to avoid possible dropout from the sport.
Ionic liquids meet lipid bilayers: a state-of-the-art review
Authors: Benedetto Antonio 
Published: January 2024

AbstractIn the past 25 years, a vast family of complex organic salts known as room-temperature ionic liquids (ILs) has received increasing attention due to their potential applications. ILs are composed by an organic cation and either an organic or inorganic anion, and possess several intriguing properties such as low vapor pressure and being liquid around room temperature. Several biological studies flagged their moderate-to-high (cyto)-toxicity. Toxicity is, however, also a synonym of affinity, and this boosted a series of biophysical and chemical-physical investigations aimed at exploiting ILs in bio-nanomedicine, drug-delivery, pharmacology, and bio-nanotechnology. Several of these investigations focused on the interaction between ILs and lipid membranes, aimed at determining the microscopic mechanisms behind their interaction. This is the focus of this review work. These studies have been carried out on a variety of different lipid bilayer systems ranging from 1-lipid to 5-lipids systems, and also on cell-extracted membranes. They have been carried out at different chemical-physical conditions and by the use of a number of different approaches, including atomic force microscopy, neutron and X-ray scattering, dynamic light scattering, differential scanning calorimetry, surface quartz microbalance, nuclear magnetic resonance, confocal fluorescence microscopy, and molecular dynamics simulations. The aim of this “2023 Michèle Auger Award” review work is to provide the reader with an up-to-date overview of this fascinating research field where “ILs meet lipid bilayers (aka biomembranes),” with the aim to boost it further and expand its cross-disciplinary edges towards novel high-impact ideas/applications in pharmacology, drug delivery, biomedicine, and bio-nanotechnology.
Persistence of Infectious Human Norovirus in Estuarine Water
Authors: Rexin Daniel , Rachmadi Andri T. , Hewitt Joanne 
Published: January 2024

AbstractNorovirus is the predominant cause of viral acute gastroenteritis globally. While person-to-person is the most reported transmission route, norovirus is also associated with waterborne and foodborne illness, including from the consumption of contaminated bivalve molluscan shellfish. The main cause of shellfish contamination is via the bioaccumulation of norovirus from growing waters impacted by human wastewater. However, data on the persistence of infectious norovirus in the environment are limited due to a lack of a human norovirus culture method in the past. In this study, we applied the recently established method of norovirus replication in human intestinal enteroids to determine the persistence of norovirus in artificial estuarine water at 25 ppt for up to 21 days at 4 °C and 16 °C in the dark. Infectious norovirus was detected for up to 21 days. The relative infectivity declined from 100 to 3% at day 21, with decay rate constants of 0.07 day−1 at 4 °C and 0.17 day−1 at 16 °C. There was no decrease in norovirus titres as measured by reverse transcription-droplet digital PCR (RT-ddPCR), confirming the lack of the relationship between norovirus infectivity and direct detection by PCR. The results confirm that norovirus can remain infectious for at least 3 weeks in an estuarine water environment, presenting associated health risks.
Zur Transformation des Bildungsverständnisses
Authors: May Michael 
Published: January 2024

ZusammenfassungAus einer Kritik der sich gegenwärtig überschneidenden Diskurse um transformatorische Bildung und Habitus sowie das Theorem der „kulturellen Passung“ bzw. Nicht-Passung werden Grundzüge eines übergreifenden Bildungsverständnisses zur Diskussion gestellt, das in der Erweiterung vorliegender Perspektiven um die Theorie der Reproduktionskodes eine aneignungstheoretische Perspektive auf Bildung eröffnet, welche die Fokussierung von (Nicht‑)Passungsverhältnissen zwischen dem Modus, wie sich Menschen bilden, und der Logik von Bildungsangeboten ermöglicht.
Associations between HIFs and tumor immune checkpoints: mechanism and therapy
Authors: Liu Jiayu , Jiang Ying , Chen Lingyan , Qian Zhiwen , Zhang Yan 
Published: January 2024

AbstractHypoxia, which activates a variety of signaling pathways to enhance tumor cell growth and metabolism, is among the primary features of tumor cells. Hypoxia-inducible factors (HIFs) have a substantial impact on a variety of facets of tumor biology, such as epithelial-mesenchymal transition, metabolic reprogramming, angiogenesis, and improved radiation resistance. HIFs induce hypoxia-adaptive responses in tumor cells. Many academics have presented preclinical and clinical research targeting HIFs in tumor therapy, highlighting the potential applicability of targeted HIFs. In recent years, the discovery of numerous pharmacological drugs targeting the regulatory mechanisms of HIFs has garnered substantial attention. Additionally, HIF inhibitors have attained positive results when used in conjunction with traditional oncology radiation and/or chemotherapy, as well as with the very promising addition of tumor immunotherapy. Immune checkpoint inhibitors (CPIs), which are employed in a range of cancer treatments over the past decades, are essential in tumor immunotherapy. Nevertheless, the use of immunotherapy has been severely hampered by tumor resistance and treatment-related toxicity. According to research, HIF inhibitors paired with CPIs may be game changers for multiple malignancies, decreasing malignant cell plasticity and cancer therapy resistance, among other things, and opening up substantial new pathways for immunotherapy drug development. The structure, activation mechanisms, and pharmacological sites of action of the HIF family are briefly reviewed in this work. This review further explores the interactions between HIF inhibitors and other tumor immunotherapy components and covers the potential clinical use of HIF inhibitors in combination with CPIs.
Exploring the relationship between immune heterogeneity characteristic genes of rheumatoid arthritis and acute myeloid leukemia
Authors: Jiang Chengzhi , Jiang Wenjuan , Liu Pengtao , Sun Wenxue , Teng Wenjie 
Published: January 2024

Abstract
Background
People with autoimmune diseases are prone to cancer, and there is a close relationship between rheumatoid arthritis (RA) and acute myeloid leukemia (AML). The bone marrow (BM) is affected throughout the course of RA, with a variety of hematologic involvement. Hopes are pinned on rheumatoid arthritis research to obtain BM biomarkers for AML.

Methods
Synovial transcriptome sequencing data for RA and osteoarthritis (OA), and single-cell sequencing data for RA and controls were obtained from the GEO database.Bone marrow sequencing data for AML patients and normal subjects were obtained from the UCSC Xena database. The final immune heterogeneity characteristics of RA were determined through ssGSEA analysis, gene differential expression analysis, fuzzy c-means clustering algorithm, and XGboost algorithm. Random Ferns classifiers (RFs) are used to identify new bone marrow markers for AML.

Results
SELL, PTPRC, IL7R, CCR7, and KLRB1 were able to distinguish leukemia cells from normal cells well, with AUC values higher than 0.970.

Conclusion
Genes characterizing the immune heterogeneity of RA are associated with AML, and KLRBA may be a potential target for AML treatment.
Diversity of forest structures important for biodiversity is determined by the combined effects of productivity, stand age, and management
Authors: Hämäläinen Aino , Runnel Kadri , Ranius Thomas , Strengbom Joachim 
Published: January 2024

AbstractIn forests, the amount and diversity of structural features with high value for biodiversity, such as large trees and dead wood, are affected by productivity, stand age, and forest management. For efficient conservation of forest biodiversity, it is essential to understand the combined effects of these drivers. We used data from the Swedish National Forest Inventory to study the combined effects of productivity, stand age, and management for wood production on structures with high value for biodiversity: tree species richness, large living trees, dead wood volume, and specific dead wood types. Forest management changed the relationship between productivity and amount or diversity of some of the structures. Most structures increased with productivity and stand age, but decreased due to management. The negative effect of management was greatest for structures occurring mainly in high-productivity forests, such as deciduous dead wood. Thus, biodiversity conservation should target high-productivity forests to preserve these structures.
Algebraic overshear density property
Authors: Andrist Rafael B. , Kutzschebauch Frank 
Published: January 2024

AbstractWe introduce the notion of the algebraic overshear density property which implies both the algebraic notion of flexibility and the holomorphic notion of the density property. We investigate basic consequences of this stronger property, and propose further research directions in this borderland between affine algebraic geometry and elliptic holomorphic geometry. As an application, we show that any smoothly bordered Riemann surface with finitely many boundary components that is embedded in a complex affine surface with the algebraic overshear density property admits a proper holomorphic embedding.
Experience with dalbavancin use in various gram-positive infections within Aberdeen Royal Infirmary OPAT service
Authors: McSorley James C , Reyes Darshini , Tonna Ivan , Bateman Vhairi 
Published: January 2024

Abstract
Purpose
Dalbavancin, approved in 2014 for Gram-positive acute bacterial skin and skin structure infections (ABSSSI), has pharmacokinetics enabling treatment with one or two doses. Dalbavancin might be useful in outpatient parenteral antibiotic therapy (OPAT) of deep-seated infections, otherwise requiring inpatient admission. We documented our experience with pragmatic dalbavancin use to assess its effectiveness for varied indications, on- and off-label, as primary or sequential consolidation therapy.

Methods
Patients prescribed dalbavancin between 1 December 2021 and 1 October 2022 were screened for demographics of age, sex, Charlson comorbidity index (CCI), allergies, pathogens, doses of dalbavancin, other antibiotics administered and surgery. Where available, infection markers were recorded. The primary outcome was a cure at the end of treatment. Secondary outcomes included any adverse events and for those with treatment failures, response to salvage antibiotics.

Results
Sixty-seven per cent of patients were cured. Cure rates by indication were 93% for ABSSSI, 100% for bacteraemia, 90% for acute osteomyelitis, 0% for chronic osteomyelitis, 75% for native joint septic arthritis and 33% for prosthetic joint infection. Most bone and joint infections that were not cured did not have source control, and the goal of treatment was suppressive. Successful suppression rates were greater at 48% for chronic osteomyelitis and 66% for prosthetic joint infections. Adverse events occurred in 14 of 102 patients.

Conclusion
This report adds to clinical experience with dalbavancin for off-label indications whilst further validating its role in ABSSSI. Dalbavancin as primary therapy in deep-seated infections merits investigation in formal clinical trials.
Facial Expression Recognition for Examining Emotional Regulation in Synchronous Online Collaborative Learning
Authors: Ngo Duong , Nguyen Andy , Dang Belle , Ngo Ha 
Published: January 2024

AbstractArtificial intelligence (AI) has been recognised as a promising technology for methodological progress and theoretical advancement in learning sciences. However, there remains few empirical investigations into how AI could be applied in learning sciences research. This study aims to utilize AI facial recognition to inform the learning regulation behaviors in synchronous online collaborative learning environments. By studying groups of university students (N = 36) who participated in their online classes under the COVID-19 social distancing mandates, we strive to understand the interrelation between individual affective states and their collaborative group members. Theoretically underpinned by the socially shared regulation of learning framework, our research features a cutting-edge insight into how learners socially shared regulation in group-based tasks. Findings accentuate fundamental added values of AI application in education, whilst indicating further interesting patterns about student self-regulation in the collaborative learning environment. Implications drawn from the study hold strong potential to provide theoretical and practical contributions to the exploration of AI supportive roles in designing and personalizing learning needs, as well as fathom the motion and multiplicity of collaborative learning modes in higher education.
Integrating prior knowledge to build transformer models
Authors: Jiang Pei , Obi Takashi , Nakajima Yoshikazu 
Published: January 2024

AbstractThe big Artificial General Intelligence models inspire hot topics currently. The black box problems of Artificial Intelligence (AI) models still exist and need to be solved urgently, especially in the medical area. Therefore, transparent and reliable AI models with small data are also urgently necessary. To build a trustable AI model with small data, we proposed a prior knowledge-integrated transformer model. We first acquired prior knowledge using Shapley Additive exPlanations from various pre-trained machine learning models. Then, we used the prior knowledge to construct the transformer models and compared our proposed models with the Feature Tokenization Transformer model and other classification models. We tested our proposed model on three open datasets and one non-open public dataset in Japan to confirm the feasibility of our proposed methodology. Our results certified that knowledge-integrated transformer models perform better (1%) than general transformer models. Meanwhile, our proposed methodology identified that the self-attention of factors in our proposed transformer models is nearly the same, which needs to be explored in future work. Moreover, our research inspires future endeavors in exploring transparent small AI models.
Enhancing Soil Organic Carbon Content and Water Retention Using Polyvinyl Alcohol Cross-linked with Chitosan and Pectin
Authors: Soliman Enas , Mansour Mostafa M. 
Published: January 2024

AbstractSoil organic carbon is considered a candidate without a substitute to be an important indicator of soil degradation by monitoring its amount and changes over time. Organic compounds such as chitosan (CS) and pectin (PC) can increase organic matter content in soils and provide a carbon source for microbes. Organic nanoparticles (NPs) were prepared by polymerization of CS and PC with polyvinyl alcohol (PVA), loaded with NPK nutrients, and evaluated by transmission electron microscope as well as zeta-potential (ZP). This study aims to test the effect of organic NPs on soil organic carbon (SOC) content, available water capacity (AWC), and growth of wheat plant. Thus, a pot experiment was conducted using clay soil. The treatments were NPK at two levels, viz., 50 and 85% of the recommended doses in combination with CS/PVA and PC/PVA as nano-carrier materials, as well as control treatment (85% NPK). Results showed that the loading of organic NPs with NPK nutrients obviously increases the solution stability and the positive as well as negative charges for CS/PVA (50.30 mV) and PC/PVA (− 17.80 mV), respectively. Furthermore, the using of NPK nano-fertilizers was significant for all the studied properties. Likewise, the addition of CS/PVA loaded with NPK decreased soil ZP at a range of − 13.00 to − 16.90 mV. Besides, it shows better carbon-cycling activity by increasing SOC at a range of 9.71 to 11.68 g kg−1. The PC/PVA loaded with 50%NPK not only increases AWC with a rate of 18.23% but also sustains water-release synchronization to meet wheat plant demands.
Impact of waste foundry sand on drainage behavior of sandy soil: an experimental and machine learning study
Authors: Kumar Ankit , Parihar Aditya 
Published: January 2024

AbstractThe study of drainage behavior is essential for using waste material in geotechnical applications. In this study, sandy soil was replaced with waste foundry sand (WFS) at an incremental interval of 20% by weight. Permeability (k) for each mix was acquired at three relative densities (RD), i.e., 65%, 75% and 85%, by using the constant head method. Then the results were further processed with machine learning (ML) models to validate the experimental data. The experimental study demonstrated that k would decrease with the increase in relative density and WFS content. A rise in RD from 65% to 85% resulted in a substantial reduction of up to 140% in the value of k. Moreover, the complete replacement of sand with WFS reduced the value of k by 36%, 51% and 57% for RD of 65%, 75% and 85%, respectively. The total dataset of 90 observations was divided at a ratio of 63/13/15 into training/validation/testing datasets for ML-AI modeling. Input variables include percentage of sand (BS), replacement with WFS, total head (H), time interval (t) and outflow (Q); and k is the output variable. The methods of artificial neural network (ANN), random forest (RF), decision tree (DT) and multi-linear regression (MLR) are used for k prediction. It is found that the random forest approach performed outstandingly in these methods, with an R2 value of 0.9955. The performance of all the proposed methods was compared and verified with Taylor's diagram. Sensitivity analysis showed that Q and RD were the most influential parameters for predicting k values.
Alternatives to antibiotics in pig production: looking through the lens of immunophysiology
Authors: Liu Hao-Yu , Zhu Chuyang , Zhu Miaonan , Yuan Long , Li Shicheng , Gu Fang , Hu Ping , Chen Shihao , Cai Demin 
Published: January 2024

AbstractIn the livestock production system, the evolution of porcine gut microecology is consistent with the idea of “The Hygiene Hypothesis” in humans. I.e., improved hygiene conditions, reduced exposure to environmental microorganisms in early life, and frequent use of antimicrobial drugs drive immune dysregulation. Meanwhile, the overuse of antibiotics as feed additives for infectious disease prevention and animal growth induces antimicrobial resistance genes in pathogens and spreads related environmental pollutants. It justifies our attempt to review alternatives to antibiotics that can support optimal growth and improve the immunophysiological state of pigs. In the current review, we first described porcine mucosal immunity, followed by discussions of gut microbiota dynamics during the critical weaning period and the impacts brought by antibiotics usage. Evidence of in-feed additives with immuno-modulatory properties highlighting probiotics, prebiotics, and phytobiotics and their cellular and molecular networking are summarized and reviewed. It may provide insights into the immune regulatory mechanisms of antibiotic alternatives and open new avenues for health management in pig production.
46,XX males with SRY gene translocation: cytogenetics and molecular characterization
Authors: Rawal Leena , Prabhash Sindhu , Kumar Ravinder , Sharma Gaurav , Shariq Mohd , Jangra Sumit , Nakra Reena , Lal Vandana , Thamtam Vamshi Krishna 
Published: January 2024

Abstract
Purpose
XX male syndrome also known as De la Chapelle syndrome/Testicular Disorder of Sex Development (DSD) is a rare genetic abnormality, identified by a partial or complete mismatch between phenotypic and genotypic gender of an individual. The present study describes the pertinent clinical, biochemical, cytogenetics, and molecular findings in four phenotypically normal males, presented with gonadal dysgenesis and hypergonadotrophic hypogonadism.

Method
Clinical characteristics and biochemical parameters in four patients were assessed. Further, chromosomal analysis has been performed using conventional karyotyping. FISH and Y chromosome microdeletion assays were carried out to confirm the presence of male-specific genes followed by microarray analysis.

Result
Chromosomal analysis revealed a 46,XX karyotype, FISH showed the presence of 2 normal X chromosomes along with translocation of the SRY gene on the short (p) arm of one of the X chromosome. Molecular analysis for Y chromosome microdeletion revealed the presence of the SRY gene with a complete absence of azoospermic factor regions (AZFa, AZFb, and AZFc) on the long (q) arm of the Y chromosome. Chromosomal microarray revealed no significant copy number variation.

Conclusions
The peculiar translocation of the SRY gene in 46,XX males strongly supports the inclusion of cytogenetic testing for establishing diagnosis and genetic counseling for infertility and/or hormonal imbalances in individuals. The present study provides insight into the cascade of events triggered by the SRY gene in the XX genome, which reinforces the differentiation towards the formation of testes while actively inhibiting ovarian development.
A review on thermochemical seasonal solar energy storage materials and modeling methods
Authors: Abdullah  , Koushaeian M. , Shah N. A. , Chung J. D. 
Published: January 2024

AbstractIn the current era, national and international energy strategies are increasingly focused on promoting the adoption of clean and sustainable energy sources. In this perspective, thermal energy storage (TES) is essential in developing sustainable energy systems. Researchers examined thermochemical heat storage because of its benefits over sensible and latent heat storage systems, such as higher energy density and decreased heat loss. Solar energy is a promising alternative among the numerous renewable energy sources. As a result, this study provides an overview of thermochemical heat storage materials, focusing on materials utilized by solar energy systems in buildings. The research examines the storage materials used in relevant studies and the models used to predict and enhance system performance.