bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Masyarakat Dalam Pengembangan Pariwisata Berdasarkan Kearifan Lokal Di Desa Wisata Adat Pinge Tabanan Bali
Authors: Ni Putu Ayu Saskarawati  , I Kadek Artha Prismawan  , Dewa Kiskenda Erwanda  
Published: December 2023

Desa wisata dikembangkan dengan adanya potensi-potensi yang ada di sebuah desa tersebut. Potensi yang dimaksud mulai dari kearifan lokal alam dan budayanya. Dalam hal ini, masyarakat lokal dilibatkan untuk membantu pengembangan pariwisata di desa wisata. Begitu juga yang dirasakan oleh masyarakat yang ada di Desa Wisata Pinge. Banyak peran aktif yang dilakukan masyarakat untuk meningkatkan dan mengembangkan Desa Pinge untuk menjadi Desa Wisata yang semakin layak dikunjungi oleh wisatawan. Maka dari itu, penelitian ini memfokuskan pada kearifan lokal dan peranan masyarakat Desa Pinge. Metode yang digunakan adalah deskriptif kualitatif dengan observasi partisipatif. Adapun narasumber yang di wawancarai yaitu Ketua Pokdarwisa Desa Pinge. Hasilnya adalah kearifan lokal yang ada di Desa Pinge dan peran masyarakat lokal dalam pengembangannya.
INTERPRETASI HUKUM EKONOMI SYARIAH DALAM FIQH ANGGARAN BERDASARKAN AKUNTANSI SYARIAH
Authors: Dewi Dyah Syahira Tara , Izzati Aisya Rahma , Aqilah Kamilatul , Hendyawan Hendyawan , Aji Gunawan 
Published: December 2023

The current global economic impact has an important impact on the welfare of a country. It's the same with corruption. In modern times, the stage of development of corrupt practices has actually started since Indonesia's independence from colonialism and even now it is not difficult to find. By using a library data collection method whose main objective is the interpretation of Syaria Economic law in budgets based on sharia accounting, which of course involves many things such as the principle of monotheism, the principle of maslahah, the principle of justice and also the urgency of budget fiqh.The application of basic principles of Islamic law in budget preparation is very important in efforts to prevent budget leaks. In this context, the existence of a fiqh budget plays an important role, not only for the interests of individuals but also for society.
Management of OFF condition in Parkinson disease
Authors: Koch Jessa 
Published: December 2023

Abstract
Parkinson disease (PD) impacts nearly 1 million individuals in the United States. Nearly every patient with PD will require therapy with dopamine in the form of levodopa as the disease progresses. In more advanced stages of the disease, patients will experience motor fluctuations and require adjustment to their medication regimens to maintain good control of their symptoms. During the last 10 years, several new therapeutic treatment options have come to the market to treat motor fluctuations and improve patient quality of life. Some of these agents represent additional options to previously available drug classes, such as the catechol-O-methyl transferase (COMT) inhibitor, opicapone, and monoamine-oxidase B-inhibitor (MAO-B inhibitor), safinamide, as well as new dosage forms for available therapeutics. One new agent, istradefylline, has a novel mechanism in the treatment of PD. The place in therapy for these newer therapeutic options will be explored through a series of patient cases. This article focuses on evidence-based recommendations for the use of these newer options in the management of patients experiencing OFF episodes.
Synthesis and Characterization of TiO2-ZnO Nanocomposite Photocatalyst for the Removal of Basic Violet 14 as an Industrial Dye
Authors: Samad Md. Abdullah Bin , Quayum Emran , Hossain Md. Amjad , Islam Tajmeri S. A. , Khan Mohammad Mahmudur Rahman 
Published: December 2023

Binary nanocomposites are one of the promising photocatalysts for the photodegradation of toxic industrial organic dyes which are used as dying agents in different industries including garments and textiles, leather, paint and varnish industries. For this study, TiO2-ZnO nanocomposites were fabricated by the hydrothermal process; where ZnSO4.7H2O is used as a precursor and TiO2 is used as a supporting material. The prepared TiO2-ZnO nanocomposites were calcined at three distinct temperatures 300 °C, 400 °C, and 500 °C. These composite materials were characterized by Scanning Electron Microscope (SEM), X-Ray Diffraction (XRD), Energy Dispersive X-Ray (EDX), and Fourier Transform Infrared (FTIR) analyzes. Basic Violet 14 (BV14), an industrial dye, was modelled to examine the photocatalytic role of TiO2-ZnO under different experimental setups such as calcined temperatures, catalyst loading, concentrations of the BV14 dye, pH, and light sources. TiO2-ZnO prepared at 500 °C acted as the best photocatalyst among three nanocomposites and the prepared TiO2-ZnO worked better than solitary TiO2 and ZnO to decolorize the BV14 dye. In the presence of sunlight, UV light, and visible light the percentages of degradation of BV14 were found to be 81.78 %, 69.58 %, and 31.24 %, respectively. The maximum photodegradation corresponded to 0.175 g/100 mL of suspension of nanocomposite with an initial 3.0×10−5 M of BV14 having solution pH 6.88. The surface reaction constant and Langmuir-Hinshelwood adsorption constant were obtained to be 5.5×10−8 mol.L−1.min−1 and 1.7×108 L.mol−1, respectively. Copyright © 2023 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Outcomes of Veterans Treated in Veterans Affairs Hospitals vs Non–Veterans Affairs Hospitals
Authors: Yoon Jean , Phibbs Ciaran S. , Ong Michael K. , Vanneman Megan E. , Chow Adam , Redd Andrew , Kizer Kenneth W. , Dizon Matthew P. , Wong Emily , Zhang Yue 
Published: December 2023

ImportanceMany veterans enrolled in the Veterans Affairs (VA) health care system have access to non-VA care through insurance and VA-purchased community care. Prior comparisons of VA and non-VA hospital outcomes have been limited to subpopulations.ObjectiveTo compare outcomes for 6 acute conditions in VA and non-VA hospitals for younger and older veterans using VA and all-payer discharge data.Design, Setting, and ParticipantsThis cohort study used a repeated cross-sectional analysis of hospitalization records for acute myocardial infarction (AMI), coronary artery bypass graft (CABG), gastrointestinal (GI) hemorrhage, heart failure (HF), pneumonia, and stroke. Participants included VA enrollees from 11 states at VA and non-VA hospitals from 2012 to 2017. Analysis was conducted from July 1, 2022, to October 18, 2023.ExposuresTreatment in VA or non-VA hospital.Main Outcome and MeasuresThirty-day mortality, 30-day readmission, length of stay (LOS), and costs. Average treatment outcomes of VA hospitals were estimated using inverse probability weighted regression adjustment to account for selection into hospitals. Models were stratified by veterans’ age (aged less than 65 years and aged 65 years and older).ResultsThere was a total of 593 578 hospitalizations and 414 861 patients with mean (SD) age 75 (12) years, 405 602 males (98%), 442 297 hospitalizations of non-Hispanic White individuals (75%) and 73 155 hospitalizations of non-Hispanic Black individuals (12%) overall. VA hospitalizations had a lower probability of 30-day mortality for HF (age ≥65 years, −0.02 [95% CI, −0.03 to −0.01]) and stroke (age &amp;lt;65 years, −0.03 [95% CI, −0.05 to −0.02]; age ≥65 years, −0.05 [95% CI, −0.07 to −0.03]). VA hospitalizations had a lower probability of 30-day readmission for CABG (age &amp;lt;65 years, −0.04 [95% CI, −0.06 to −0.01]; age ≥65 years, −0.05 [95% CI, −0.07 to −0.02]), GI hemorrhage (age &amp;lt;65 years, −0.04 [95% CI, −0.06 to −0.03]), HF (age &amp;lt;65 years, −0.05 [95% CI, −0.07 to −0.03]), pneumonia (age &amp;lt;65 years, −0.04 [95% CI, −0.06 to −0.03]; age ≥65 years, −0.03 [95% CI, −0.04 to −0.02]), and stroke (age &amp;lt;65 years, −0.11 [95% CI, −0.13 to −0.09]; age ≥65 years, −0.13 [95% CI, −0.16 to −0.10]) but higher probability of readmission for AMI (age &amp;lt;65 years, 0.04 [95% CI, 0.01 to 0.06]). VA hospitalizations had a longer mean LOS and higher costs for all conditions, except AMI and stroke in younger patients.Conclusions and RelevanceIn this cohort study of veterans, VA hospitalizations had lower mortality for HF and stroke and lower readmissions, longer LOS, and higher costs for most conditions compared with non-VA hospitalizations with differences by condition and age group. There were tradeoffs between better outcomes and higher resource use in VA hospitals for some conditions.
Human Motor System‐Based Biohybrid Robot‐On‐a‐Chip for Drug Evaluation of Neurodegenerative Disease
Authors: Shin Minkyu , Ha Taehyeong , Lim Joungpyo , An Joohyun , Beak Geunyoung , Choi Jin‐Ha , Melvin Ambrose Ashwin , Yoon Jinho , Choi Jeong‐Woo 
Published: December 2023

AbstractBiohybrid robots have been developed for biomedical applications and industrial robotics. However, the biohybrid robots have limitations to be applied in neurodegenerative disease research due to the absence of a central nervous system. In addition, the organoids‐on‐a‐chip has not yet been able to replicate the physiological function of muscle movement in the human motor system, which is essential for evaluating the accuracy of the drugs used for treating neurodegenerative diseases. Here, a human motor system‐based biohybrid robot‐on‐a‐chip composed of a brain organoid, multi‐motor neuron spheroids, and muscle bundle on solid substrateis proposed to evaluate the drug effect on neurodegenerative diseases for the first time. The electrophysiological signals from the cerebral organoid induced the muscle bundle movement through motor neuron spheroids. To evaluate the drug effect on Parkinson's disease (PD), a patient‐derived midbrain organoid is generated and incorporated into a biohybrid robot‐on‐a‐chip. The drug effect on PD is successfully evaluated by measuring muscle bundle movement. The muscle bundle movement of PD patient‐derived midbrain organoid‐based biohybrid robot‐on‐a‐chip is increased from 4.5 ± 0.99 µm to 18.67 ± 2.25 µm in response to levodopa. The proposed human motor system‐based biohybrid robot‐on‐a‐chip can serve as a standard biohybrid robot model for drug evaluation.
Hofmeister Effect Promoted the Introduction of Tunable Large Mesopores in MOFs at Low Temperature for Femtomolar ALP Detection
Authors: Yang Jian , Gong Ming , Xia Fan , Tong Yao , Gu Jinlou 
Published: December 2023

AbstractIn addressing the demand for hierarchically mesoporous metal‐organic frameworks (HMMOFs) with adjustable large mesopores, a method based on the synergistic effects of low‐temperature microemulsions and Hofmeister ions is developed. Low temperature dramatically enhanced the solubility of hydrophobic solvent in the microemulsion core, enlarging the mesopores in HMMOFs replica. Meanwhile, Hofmeister salt‐in ions continuously controlled mesopore expansion by modulating the permeability of swelling agent into the microemulsion core. The large mesopores up to 33 nm provided sufficient space for the alkaline phosphatase (ALP) enrichment, and retained the remaining channel to facilitate the free mass diffusion. Leveraging these advantages, a colorimetric sensor is successfully developed using large‐mesopore HMMOFs for femtomolar ALP detection based on the enrichment and cycling amplification principles. The sensor exhibited a linear detection range of 100 to 7500 fm and a limit of detection of 42 fm, presenting over 4000 times higher sensitivity than classic para‐nitrophenyl phosphate colorimetric methods. Such high sensitivity highlights the importance of adjustable mesoporous structures of HMMOFs in advanced sensing applications, and prefigures their potential for detecting large biomolecules in diagnostics and biomedical research.
Cyclic Polyesters with Closed‐Loop Recyclability from A New Chemically Reversible Alternating Copolymerization
Authors: Lu Xiaoxian , Zhang Xun , Zhang Chengjian , Zhang Xinghong 
Published: December 2023

AbstractPolyesters with both cyclic topology and chemical recyclability are attractive. Here, the alternating copolymerization of cyclic anhydride and o‐phthalaldehyde to synthesize a series of cyclic and recyclable polyesters are reported for the first time. Besides readily available monomers, the copolymerization is carried out at 25 °C, uses common Lewis/Brønsted acids as catalysts, and achieves high yields within 1 h. The resulting polyesters possess well‐defined alternating sequences, high‐purity cyclic topology, and tunable structures using distinct two monomer sets. Of interest, the copolymerization manifests obvious chemical reversibility as revealed by kinetic and thermodynamic studies, making the unprecedented polyesters easy to recycle to their distinct two monomers in a closed loop at high temperatures. This work furnishes a facile and efficient method to synthesize cyclic polyesters with closed‐loop recyclability.
Efficient and Stable Tin–Lead Perovskite Photoconversion Devices Using Dual‐Functional Cathode Interlayer
Authors: Mubarok Muhibullah Al , Choi Yuri , Mehrotra Rashmi , Kim Yu Jin , Boddu Rama Krishna , Lee Inhui , Kim Jiyeong , Kwak Sang Kyu , Jang Ji‐Wook , Ryu Jungki , Jang Sung‐Yeon 
Published: December 2023

AbstractTin–lead halide perovskites (TLHPs) are promising photoactive materials for photovoltaics (PVs) due to reduced toxicity and broad light absorption. However, their inherent ionic vacancies facilitate inward metal diffusion, accelerating device degradation. Here, efficient, stable TLHP‐based PV and photoelectrochemical (PEC) devices are reported containing a chemically protective cathode interlayer—amine‐functionalized perylene diimide (PDINN). Solution‐processed PDINN effectively extract electrons and suppress inward‐metal diffusion by forming tridentate metal complexes with its nucleophilic sites. The PV device achieved an efficiency of 23.21% (>81% retention after 750 h at 60 °C and >90% retention after 3100 h at 23 ± 4 °C), and the first demonstration of TLHP‐based PEC devices exhibit a record‐high bias‐free solar hydrogen production rate (33.0 mA cm−2; ≈3.42 × 10−6 kg s−1 m−2) when coupled with biomass oxidation, which is ≈1.7‐fold higher than the ultimate target set by the U.S. Department of Energy for one‐sun hydrogen production. These findings demonstrate the potential of TLHPs for efficient, stable photoconversion by the molecular design of the cathode interlayer.
Inhibiting Dendrite Formation and Electrode Corrosion via a Scalable Self‐Assembled Mercaptan Layer for Stable Aqueous Zinc Batteries
Authors: Ren Baohui , Hu Sanlue , Chen Ao , Zhang Xiangyong , Wei Hua , Jiang Jingjing , Chen Guangming , Zhi Chunyi , Li Hongfei , Liu Zhuoxin 
Published: December 2023

AbstractThe practical use of Zn metal anodes in aqueous zinc batteries is impeded by the growth of dendrites, anode corrosion, and hydrogen evolution reaction in aqueous electrolytes. In this study, a simple, energy‐efficient, and scalable approach is reported to mitigate these detrimental issues effectively. Using 1‐hexanethiol (HT), a hydrophobic self‐assembled mercaptan layer (SAML) with a highly ordered structure is in situ created on the surface of the Zn anode. This ultrathin interfacial structure guides uniform Zn deposition and shields the Zn anode from water and oxygen‐induced corrosion, thus effectively inhibiting dendrite formation and side reactions. Consequently, the HT‐Zn electrode showcases impressive electrochemical stability and reversibility, and the as‐assembled HT‐Zn||I2 full cell delivers increased specific capacity (from 112 to 155 mAh g−1 at 1 A g−1) and ultra‐stable cyclability (zero capacity decay during the extended 1500 cycles at 4 A g−1). To validate the effectiveness of this simple and scalable method, a large‐sized pouch cell is prepared, which can be stably operated for 1000 cycles with a capacity decay of merely 0.0098% per cycle and Coulombic efficiency exceeding 99.1%. The presented SAML strategy highlights the potential of molecular engineering in improving the performance of aqueous zinc batteries.
Scene construction and autobiographical memory retrieval in autism spectrum disorder
Authors: Agron Anna M. , Martin Alex , Gilmore Adrian W. 
Published: December 2023

AbstractIndividuals with autism spectrum disorder (ASD) frequently exhibit difficulties in retrieving autobiographical memories (AMs) of specific events from their life. Such memory deficits are frequently attributed to underlying disruptions in self‐referential or social cognition processes. This makes intuitive sense as these are hallmarks of ASD. However, an emerging literature suggests that parallel deficits also exist in ASD individuals' ability to reconstruct the rich spatial contexts in which events occur. This is a capacity known as scene construction, and in typically developing individuals is considered a core process in retrieving AMs. In this review, we discuss evidence of difficulties with scene construction in ASD, drawing upon experiments that involve AM retrieval, other forms of mental time travel, and spatial navigation. We also highlight aspects of extant data that cannot be accounted for using purely social explanations of memory deficits in ASD. We conclude by identifying key questions raised by our framework and suggest how they might be addressed in future research.
Human mesenchymal stem cells increase LLC metastasis and stimulate or decelerate tumor development depending on injection method and cell amount
Authors: Stepanov Yurii V. , Golovynska Iuliia , Ostrovska Galyna , Pylyp Larysa , Dovbynchuk Taisa , Stepanova Liudmyla I. , Gorbach Oleksandr , Shablii Volodymyr , Xu Hao , Garmanchuk Liudmyla V. , Ohulchanskyy Tymish Y. , Qu Junle , Solyanik Galina I. 
Published: December 2023

AbstractMesenchymal stem cells (MSCs) being injected into the body can stimulate or decelerate carcinogenesis. Here, the direction of influence of human placenta‐derived MSCs (P‐MSCs) on the Lewis lung carcinoma (LLC) tumor development and metastatic potential is investigated in C57BL/6 mice depending on the injection method. After intramuscular co‐inoculation of LLC and P‐MSCs (LLC + P‐MSCs), the growth of primary tumor and angiogenesis are slowed down compared to the control LLC on the 15th day. This is explained by the fact of a decrease in the secretion of proangiogenic factors during in vitro co‐cultivation of an equal amount of LLC and P‐MSCs. When P‐MSCs are intravenously (i.v.) injected in the mice with developing LLC (LLC + P‐MSCs(i.v.)), the tumor growth and angiogenesis are stimulated on the 15th day. A highly activated secretion of proangiogenic factors by P‐MSCs in a similar in vitro model can explain this. In both the models compared to the control on the 23rd day, there is no significant difference in the tumor growth, while angiogenesis remains correspondingly decelerated or stimulated. However, in both the models, the total volume and number of lung metastases constantly increase compared to the control: it is mainly due to small‐size metastases for LLC + P‐MSCs(i.v.) and larger ones for LLC + P‐MSCs. The increase in the rate of LLC cell dissemination after the injection of P‐MSCs is explained by the disordered polyploidy and chromosomal instability, leading to an increase in migration and invasion of cancer cells. After LLC + P‐MSCs co‐inoculation, the tumor cell karyotype has the most complex and heterogeneous chromosomal structure. These findings indicate a bidirectional effect of P‐MSCs on the growth of LLC in the early periods after injection, depending on the injection method, and, correspondingly, the number of contacting cells. However, regardless of the injection method, P‐MSCs are shown to increase LLC aggressiveness related to cancer‐associated angiogenesis and metastasis activation in the long term.
Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors—A review
Authors: Rauf Abdur , Khalil Anees Ahmed , Awadallah Samir , Khan Shahid Ali , Abu‐Izneid Tareq , Kamran Muhammad , Hemeg Hassan A. , Mubarak Mohammad S. , Khalid Ahood , Wilairatana Polrat 
Published: December 2023

AbstractReactive oxygen species (ROS) are produced under normal physiological conditions and may have beneficial and harmful effects on biological systems. ROS are involved in many physiological processes such as differentiation, proliferation, necrosis, autophagy, and apoptosis by acting as signaling molecules or regulators of transcription factors. In this case, maintaining proper cellular ROS levels is known as redox homeostasis. Oxidative stress occurs because of the imbalance between the production of ROS and antioxidant defenses. Sources of ROS include the mitochondria, auto‐oxidation of glucose, and enzymatic pathways such as nicotinamide adenine dinucleotide phosphate reduced (NAD[P]H) oxidase. The possible ROS pathways are NF‐κB, MAPKs, PI3K‐Akt, and the Keap1‐Nrf2‐ARE signaling pathway. This review covers the literature pertaining to the possible ROS pathways and strategies to inhibit them. Additionally, this review summarizes the literature related to finding ROS inhibitors.
Is illiquidity priced in an international factor pricing model? A dynamic panel data application with robust IV
Authors: Racicot François‐Eric , Rentz William F. , Théoret Raymond 
Published: December 2023

AbstractIn the setting of a dynamic panel data framework, we investigate the international five‐factor Fama–French (2017) model augmented with traditional illiquidity factors (Amihud, Journal of Financial Markets, 2002, 5, 31–56; Amihud, Critical Finance Review, 2019, 8, 203–221; Pástor and Stambaugh, Journal of Political Economy, 2003, 111, 642–685; Pástor and Stambaugh, Critical Finance Review, 2019, 8, 277–299) to determine if any of these factors are priced. Since illiquidity measures are endogenous, we propose an algorithm that generates robust instruments which are combined with a GMM estimator to cope with both the endogeneity issues surrounding illiquidity and other eventual specification errors. In this dynamic framework, we generally find that the most significant factors correspond to market and size but illiquidity may matter depending on the level of the beta. We find that illiquidity has more impact on returns in expansion than in recession. However, the bid‐ask spread seems to behave differently from the other illiquidity measures.