bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actualizacion Del Metodo Ablativo Con Aguja Percutanea De Etanol
Authors: Nuñez Silva David Sebastian 
Published: January 2024

La prevalencia de los nódulos de tiroides ha ido incrementando de forma significativa en los últimos años , lo mismo que ha generado gran preocupación e incertidumbre tanto en el paciente como en el personal médico, más del 50% de pacientes que se realizan una ecografía de cuello son portadores de nódulos de tejido tiroideo , por lo cual se ha buscado disminuir la taza de procedimientos invasivos y la necesidad de buscar nuevos métodos que permitan disminuir síntomas clínicos relacionados con nódulos de carácter benigno , pues la ablación con etanol en las últimas décadas ha demostrado ser un método con resultados significativamente exitosos y con un porcentaje mínimo de complicaciones , existen diversos estudios , acerca de los beneficios brindados por la inyección percutánea con etanol bajo guía ecográfica , en nódulos de tiroides funcionantes y no funcionantes , además de su gran éxito en aquellos nódulos de carácter quístico y mixtos . Objetivo: Analizar la literatura disponible acerca de la ablación con etanol, técnica, eficacia, e indicaciones. Método: Revisión Bibliográfica Sistematizada de literatura basada en la selección de artículos científicos de los últimos años. Resultado: Los nódulos de tiroides son lesiones circunscritas a nivel del tejido de la tiroides, en la mayoría de los casos suelen ser benignos, asintomáticos con un tamaño y volumen variable, se evidencia una alta tasa de éxito en pacientes sometidos ablación con etanol la misma que se encuentra proporcionalmente relacionada al volumen nodular, especialmente en nódulos puramente quísticos y mixtos. Conclusiones: La ablación percutánea con etanol es uno de los métodos con gran porcentaje de efectividad tras la reducción de volumen en nódulos de tiroides puramente quísticos y mixtos benignos, además ha demostrado efectividad con un porcentaje menor en nódulos con características sólidas, siendo uno de los métodos con menos tasa de complicaciones, se considera un método económicamente sustentable, que utiliza una técnica mínimamente invasiva.
Fortalecimiento de la Modalidad Técnica Agropecuaria a Través de la Gestión de Proyectos Pedagógicos Productivos Utilizando la Ruta Crítica CPM en la Institución Educativa Manuel Briceño.
Authors: Velásquez Triana John Dave 
Published: January 2024

La investigación presenta una propuesta educativa cuyo propósito es aportar al fortalecimiento de la modalidad técnica agropecuaria en la Institución Educativa Manuel Briceño del Municipio de Briceño, Departamento de Boyacá, mediante la implementación de los proyectos pedagógicos productivos. Esta idea se realizara a partir de un diagnóstico y caracterización, para poder evidenciar que la formación agropecuaria en los estudiantes del municipio tiene un impacto directo en el desarrollo económico de la región, en lo cultural y social. El desarrollo económico es agrícola y esto genera una identidad cultural campesina a lo que se puede sacar provecho como alternativas de desarrollo acordes a sus prácticas y modo de vida. (Villamil, 2018). La investigación se implementó desde un enfoque exploratorio. Para las fuentes de información se realizó una encuesta. Lo que se busca del análisis y resultados es que si bien, se aplica los reajustes al proyecto educativo y las estrategias de enseñanza en las áreas de la modalidad se obtendrán aprendizaje cognoscitivo, procedimental y actitudinal en las competencias que se requiere mejorar. De esta manera, este estudio es una herramienta pedagógica para aplicar en el campo productivo y emprendimiento que se necesita para desarrollar el impacto económico y social en la comunidad.
Escucha Activa como Estrategia Didáctica para el Desarrollo de Habilidades Sociales en Estudiantes del Bachillerato
Authors: Mejía Guachichullca Carlos Eduardo , Segovia Bermeo Andrea del Pilar , Encalada Chuncho Samantha Denisse , Figueroa Solano Sandra del Rocío 
Published: January 2024

El propósito central de este artículo consiste en examinar inferencia los niveles de aplicación de la escucha activa como estrategia didáctica para el desarrollo de habilidades sociales en estudiantes del bachillerato general unificado, Con el fin de lograr este propósito, se realizó una revisión documental siguiendo el modelo PRISMA, que inicialmente abarcó 363 documentos y que al final se redujo a 42 documentos para su análisis detallado. Los resultados revelan que los estudiantes que desarrollan adecuadas competencias de escucha activan en todas sus dimensiones, mejoran los niveles de habilidades sociales, características muy importantes para un crecimiento personal y profesional.
On the Nature of Disks at High Redshift Seen by JWST/CEERS with Contrastive Learning and Cosmological Simulations
Authors: Vega-Ferrero Jesús , Huertas-Company Marc , Costantin Luca , Pérez-González Pablo G. , Sarmiento Regina , Kartaltepe Jeyhan S. , Pillepich Annalisa , Bagley Micaela B. , Finkelstein Steven L. , McGrath Elizabeth J. , Knapen Johan H. , Haro Pablo Arrabal , Bell Eric F. , Buitrago Fernando , Calabrò Antonello , Dekel Avishai , Dickinson Mark , Domínguez Sánchez Helena , Elbaz David , Ferguson Henry C. , Giavalisco Mauro , Holwerda Benne W. , Kocesvski Dale D. , Koekemoer Anton M. , Pandya Viraj , Papovich Casey , Pirzkal Nor , Primack Joel , Yung L. Y. Aaron 
Published: January 2024

Abstract
Visual inspections of the first optical rest-frame images from JWST have indicated a surprisingly high fraction of disk galaxies at high redshifts. Here, we alternatively apply self-supervised machine learning to explore the morphological diversity at z ≥ 3. Our proposed data-driven representation scheme of galaxy morphologies, calibrated on mock images from the TNG50 simulation, is shown to be robust to noise and to correlate well with the physical properties of the simulated galaxies, including their 3D structure. We apply the method simultaneously to F200W and F356W galaxy images of a mass-complete sample (M
*/M
⊙ > 109) at 3 ≤ z ≤ 6 from the first JWST/NIRCam CEERS data release. We find that the simulated and observed galaxies do not exactly populate the same manifold in the representation space from contrastive learning. We also find that half the galaxies classified as disks—either convolutional neural network-based or visually—populate a similar region of the representation space as TNG50 galaxies with low stellar specific angular momentum and nonoblate structure. Although our data-driven study does not allow us to firmly conclude on the true nature of these galaxies, it suggests that the disk fraction at z ≥ 3 remains uncertain and possibly overestimated by traditional supervised classifications. Deeper imaging and spectroscopic follow-ups as well as comparisons with other simulations will help to unambiguously determine the true nature of these galaxies, and establish more robust constraints on the emergence of disks at very high redshift.
EMPRESS. XII. Statistics on the Dynamics and Gas Mass Fraction of Extremely Metal-poor Galaxies
Authors: Xu Yi , Ouchi Masami , Isobe Yuki , Nakajima Kimihiko , Ozaki Shinobu , Bouché Nicolas F. , Wise John H. , Emsellem Eric , Kusakabe Haruka , Hattori Takashi , Nagao Tohru , Chiaki Gen , Fukushima Hajime , Harikane Yuichi , Hayashi Kohei , Hirai Yutaka , Kim Ji Hoon , Maseda Michael V. , Nagamine Kentaro , Shibuya Takatoshi , Sugahara Yuma , Yajima Hidenobu , Aoyama Shohei , Fujimoto Seiji , Fukushima Keita , Hatano Shun , Inoue Akio K. , Ishigaki Tsuyoshi , Kawasaki Masahiro , Kojima Takashi , Komiyama Yutaka , Koyama Shuhei , Koyama Yusei , Lee Chien-Hsiu , Matsumoto Akinori , Mawatari Ken , Moriya Takashi J. , Motohara Kentaro , Murai Kai , Nishigaki Moka , Onodera Masato , Ono Yoshiaki , Rauch Michael , Saito Tomoki , Sasaki Rin , Suzuki Akihiro , Takeuchi Tsutomu T. , Umeda Hiroya , Umemura Masayuki , Watanabe Kuria , Yabe Kiyoto , Zhang Yechi 
Published: January 2024

Abstract
We present the demography of the dynamics and gas mass fraction of 33 extremely metal-poor galaxies (EMPGs) with metallicities of 0.015–0.195 Z
⊙ and low stellar masses of 104–108
M
⊙ in the local universe. We conduct deep optical integral field spectroscopy (IFS) for the low-mass EMPGs with the medium-high resolution (R = 7500) grism of the 8 m Subaru FOCAS IFU instrument by the EMPRESS 3D survey, and investigate the Hα emission of the EMPGs. Exploiting the resolution high enough for the low-mass galaxies, we derive gas dynamics with the Hα lines by the fitting of three-dimensional disk models. We obtain an average maximum rotation velocity (v
rot) of 15 ± 3 km s−1 and an average intrinsic velocity dispersion (σ
0) of 27 ± 10 km s−1 for 15 spatially resolved EMPGs out of 33 EMPGs, and find that all 15 EMPGs have v
rot/σ
0 < 1 suggesting dispersion-dominated systems. There is a clear decreasing trend of v
rot/σ
0 with the decreasing stellar mass and metallicity. We derive the gas mass fraction (f
gas) for all 33 EMPGs, and find no clear dependence on stellar mass and metallicity. These v
rot/σ
0 and f
gas trends should be compared with young high-z galaxies observed by the forthcoming JWST IFS programs to understand the physical origins of the EMPGs in the local universe.
Fine-structure Transitions of Ne+, Ar+, Ne2+, and Ar2+ Induced by Collisions with Atomic Hydrogen
Authors: Yan Pei-Gen , Babb James F. 
Published: January 2024

Abstract
We calculate cross sections for fine-structure transitions of Ne+, Ar+, Ne2+, and Ar2+ in collisions with atomic hydrogen by using quantum-mechanical methods. Relaxation rate coefficients are calculated for temperatures up to 10,000 K. The temperature-dependent critical densities for the relaxation of Ne+, Ar+, Ne2+, and Ar2+ in collisions with H have been determined and compared to the critical densities for collisions with electrons. The present calculations will be useful for studies utilizing the infrared lines [Ne ii] 12.8, [Ne iii] 15.6, [Ne iii] 36.0, [Ar ii] 6.99, [Ar iii] 8.99, and [Ar iii] 21.8 μm as diagnostics of, for example, planetary nebulae and star formation.
A Possible Optical Quasiperiodic Oscillation of 134 days in the Radio-loud Narrow-line Seyfert 1 Galaxy TXS 1206+549 at z = 1.34
Authors: Ren Chongyang , Sun Sisi , Zhang Pengfei 
Published: January 2024

Abstract
Here we report an optical quasiperiodic oscillation (QPO) with a period of ∼134 days detected in g- and r-band light curves of the narrow-line Seyfert 1 galaxy TXS 1206+549 at a redshift of 1.34 with data from observations at the Zwicky Transient Facility (ZTF). After considering the trial factor, the significance levels in the two bands are 3.1σ and 2.6σ, respectively. The QPO signal presents about 10 cycles ranging from 2018 March to 2021 December, thus lasting ∼4 yr. A nearly sinusoidal profile also appears in the folded light curves by using a phase-resolved analysis. Interestingly, in the simultaneous light curve with the timescale of ZTF observations, a potential periodic signal with a similar period is detected in the o-band light curve from Asteroid Terrestrial-impact Last Alert System data; additionally, a weak peak is also detected at a similar period in the γ-ray light curve obtained from Fermi Gamma-ray Space Telescope data. Some potential origins of periodicities in active galactic nuclei are discussed for the QPO reported here.
Engagement explicite, engagement implicite. L’exemple du discours sur la chasse
Authors: Kerbrat-Orecchioni Catherine 
Published: January 2024

Par opposition à certains discours ouvertement « pro-chasse » ou « anti-chasse », le propos de Charles Stépanoff dans L’Animal et la mort se veut respectueux de la neutralité censée caractériser le discours scientifique. Pourtant, certains commentateurs n’ont pas manqué de voir dans cet essai une forme de réhabilitation de la chasse, ce qui pose le problème de savoir ce qui peut produire un tel effet de lecture, et sur quels indices peut reposer une telle interprétation. Il apparaît que dans ce texte, la valorisation de la chasse se fait d’une part à travers la représentation d’un chasseur paré de toutes les vertus, cette valorisation du praticien entraînant par ricochet métonymique celle de la pratique elle-même. D’autre part, cette pratique se trouve légitimée grâce à différents procédés, argumentatifs ou rhétoriques (comme le recours massif à l’euphémisme), qui convergent dans le texte de Stépanoff pour créer l’impression d’un engagement implicite en faveur de l’activité cynégétique, et corrélativement d’une critique du « pathocentrisme » contemporain, responsable de l’hostilité envers cette activité.
La griffe du greffier. Autobiographies félines chez Ernst Theodor Amadeus Hoffmann et Joann Sfar
Authors: Tellier Virginie 
Published: January 2024

L’article porte sur la comparaison du Chat Murr de Ernst Theodor Amadeus Hoffmann (1819-1822) et du Chat du rabbin. 1, la Bar-Mitsva de Joann Sfar (2002). Il s’interroge sur le rôle spécifique dévolu au personnage félin dans la mise en œuvre d’une défamiliarisation (ostranenie) propre au littéraire. Il s’attache d’abord à montrer comment les deux auteurs procèdent pour rendre compte d’un point de vue félin sur le monde, à partir de mécanismes langagiers et iconiques spécifiques. Il s’intéresse ensuite aux jeux d’autobiographie en miroir, et à la manière dont ce langage animal permet de repenser, pour les auteurs humains, le rapport à soi et au monde, afin de recréer une familiarité, par-delà la défamiliarisation. Il tente ensuite de définir une poétique du silence et du non-dit, la parole animale venant, chez E. T. A. Hoffmann comme chez J. Sfar, interroger la manière dont l’art répond au silence métaphysique auquel se confronte l’être humain.
À propos de la loi pour contrôler l'immigration, améliorer l'intégration, entretien avec Danièle Lochak, professeure émérite de l’Université Paris Nanterre (CTAD-Credof), membre et ancienne présidente du Gisti
Authors: Lochak Danièle 
Published: January 2024

Le présent entretien ouvre une série d’interviews réalisés avec plusieurs enseignants chercheurs spécialistes du droit des étrangers mais aussi de la chose politique. Face à la brutalité du projet de loi, tant dans ses aspects substantiels que procéduraux, et compte tenu des critiques importantes dont il fait l’objet, il est apparu nécessaire aux Lettres d’actualité de réagir en offrant à ces experts un espace pour livrer leur analyse sur les conséquences de cette réforme en termes de droits fondamentaux. Une publication sous forme d’entretien est apparue la plus opportune pour informer les lecteurs des multiples enjeux que le texte soulève sur ses différents aspects : en matière d’entrée et de séjour, de droit du travail et de protection sociale, de droit d’asile, mais encore sur le plan institutionnel et politique.
Development of a New Off-the-Shelf Plasmacytoid Dendritic Cell–Based Approach for the Expansion and Characterization of SARS-CoV-2–Specific T Cells
Authors: Maino Anthony , Amen Axelle , Plumas Joël , Bouquet Lucie , Deschamps Marina , Saas Philippe , Chaperot Laurence , Manches Olivier 
Published: January 2024

Abstract
Global vaccination against COVID-19 has been widely successful; however, there is a need for complementary immunotherapies in severe forms of the disease and in immunocompromised patients. Cytotoxic CD8+ T cells have a crucial role in disease control, but their function can be dysregulated in severe forms of the disease. We report here a cell-based approach using a plasmacytoid dendritic cell line (PDC*line) to expand in vitro specific CD8+ responses against COVID-19 Ags. We tested the immunogenicity of eight HLA-A*02:01 restricted peptides derived from diverse SARS-Cov-2 proteins, selected by bioinformatics analyses in unexposed and convalescent donors. Higher ex vivo frequencies of specific T cells against these peptides were found in convalescent donors compared with unexposed donors, suggesting in situ T cell expansion upon viral infection. The peptide-loaded PDC*line induced robust CD8+ responses with total amplification rates that led up to a 198-fold increase in peptide-specific CD8+ T cell frequencies for a single donor. Of note, six of eight selected peptides provided significant amplifications, all of which were conserved between SARS-CoV variants and derived from the membrane, the spike protein, the nucleoprotein, and the ORF1ab. Amplified and cloned antiviral CD8+ T cells secreted IFN-γ upon peptide-specific activation. Furthermore, specific TCR sequences were identified for two highly immunogenic Ags. Hence, PDC*line represents an efficient platform to identify immunogenic viral targets for future immunotherapies.
The effect of previous endoscopic retrograde cholangiopancreatography on subsequent laparoscopic cholecystectomy: The retrospective analysis of 1500 patients
Authors: Emre Balli , Mehlika Bilgi Kirmaci , Metehan Aydin , Taylan Ugurlu Esat , Sezgin Yilmaz 
Published: January 2024

Abstract

Introduction:
Laparoscopic cholecystectomy (LC) is the gold standard for patients with acute cholecystitis at early period. However, 15%–20% of patients with acute cholecystitis develop obstructive jaundice, cholangitis and bile duct stones ultimately requiring endoscopic retrograde cholangiopancreatography (ERCP). In such cases, a two-session approach is usually recommended, first ERCP followed by LC thereafter. However, the effect of prior ERCP on the difficulty of subsequent LC is unknown. Hence, the aim of the present study is to determine the effects of previous ERCP on the results of LC.

Patients and Methods:
In this study, the files of 1500 patients who underwent LC were reviewed retrospectively. The patients were divided into three groups (500 patients for each group). The patients undergoing LC for asymptomatic cholelithiasis were assigned to the L-e group. The patients who underwent LC for acute cholecystitis were assigned to the L-c group. The patients with acute cholecystitis who underwent ERCP first and then LC were assigned to the L-ercp group. The rates of conversion to open cholecystectomy, operation times, complication rates and hospital stays of the three groups were compared.

Results:
The results of LC performed after ERCP are similar to the results of LC for cholecystitis without ERCP in terms of operation time, hospital stay, conversion and complications.

Conclusions:
Previous ERCP does not affect the safety and effectiveness of early LC in patients with acute cholecystitis.
Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway
Authors: Xu Wei-Long , Zhou Pei-Pei , Yu Xu , Tian Ting , Bao Jin-Jing , Ni Chang-Rong , Zha Min , Wu Xiao , Yu Jiang-Yi 
Published: January 2024

BACKGROUND
Development of end-stage renal disease is predominantly attributed to diabetic nephropathy (DN). Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal tissue. Nevertheless, the precise molecular mechanism through which myricetin influences the progression of DN remains uncertain.
AIM
To investigate the effects of myricetin on DN and explore its potential therapeutic mechanism.
METHODS
Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 wk. Subsequently, blood and urine indexes were assessed, along with examination of renal tissue pathology. Kidney morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin, periodic acid–Schiff, Masson’s trichrome, and Sirius-red. Additionally, high-glucose culturing was conducted on the RAW 264.7 cell line, treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 h. In both in vivo and in vitro settings, quantification of inflammation factor levels was conducted using western blotting, real-time qPCR and ELISA.
RESULTS
In db/db mice, administration of myricetin led to a mitigating effect on DN-induced renal dysfunction and fibrosis. Notably, we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin, along with a decrease in expressions of inflammatory cytokine-related factors. Furthermore, myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha, interleukin-6, and interluekin-1β induced by high glucose in RAW 264.7 cells. Additionally, myricetin modulated the M1-type polarization of the RAW 264.7 cells. Molecular docking and bioinformatic analyses revealed Akt as the target of myricetin. The protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inhibition of PI3K/Akt activation using LY294002.
CONCLUSION
This study demonstrated that myricetin effectively mitigates kidney injury in DN mice through the regulation of macrophage polarization via the PI3K/Akt signaling pathway.
Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients
Authors: Desai Rupak , Katukuri Nishanth , Goguri Sumaja Reddy , Kothawala Azra , Alle Naga Ruthvika , Bellamkonda Meena Kumari , Dey Debankur , Ganesan Sharmila , Biswas Minakshi , Sarkar Kuheli , Prattipati Pramoda , Chauhan Shaylika 
Published: January 2024

BACKGROUND
Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events (MACCE). However, the relationship between prediabetes and MACCE in atrial fibrillation (AF) patients has not been extensively studied. Therefore, this study aimed to establish a link between prediabetes and MACCE in AF patients.
AIM
To investigate a link between prediabetes and MACCE in AF patients.
METHODS
We used the National Inpatient Sample (2019) and relevant ICD-10 CM codes to identify hospitalizations with AF and categorized them into groups with and without prediabetes, excluding diabetics. The primary outcome was MACCE (all-cause inpatient mortality, cardiac arrest including ventricular fibrillation, and stroke) in AF-related hospitalizations.
RESULTS
Of the 2965875 AF-related hospitalizations for MACCE, 47505 (1.6%) were among patients with prediabetes. The prediabetes cohort was relatively younger (median 75 vs 78 years), and often consisted of males (56.3% vs 51.4%), blacks (9.8% vs 7.9%), Hispanics (7.3% vs 4.3%), and Asians (4.7% vs 1.6%) than the non-prediabetic cohort (P < 0.001). The prediabetes group had significantly higher rates of hypertension, hyperlipidemia, smoking, obesity, drug abuse, prior myocardial infarction, peripheral vascular disease, and hyperthyroidism (all P < 0.05). The prediabetes cohort was often discharged routinely (51.1% vs 41.1%), but more frequently required home health care (23.6% vs 21.0%) and had higher costs. After adjusting for baseline characteristics or comorbidities, the prediabetes cohort with AF admissions showed a higher rate and significantly higher odds of MACCE compared to the non-prediabetic cohort [18.6% vs 14.7%, odds ratio (OR) 1.34, 95% confidence interval 1.26-1.42, P < 0.001]. On subgroup analyses, males had a stronger association (aOR 1.43) compared to females (aOR 1.22), whereas on the race-wise comparison, Hispanics (aOR 1.43) and Asians (aOR 1.36) had a stronger association with MACCE with prediabetes vs whites (aOR 1.33) and blacks (aOR 1.21).
CONCLUSION
This population-based study found a significant association between prediabetes and MACCE in AF patients. Therefore, there is a need for further research to actively screen and manage prediabetes in AF to prevent MACCE.