bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between Clinical Examination, Magnetic Resonance Imaging, and Arthroscopy in Meniscal Injuries of the Knee: A Prospective Cohort Study
Authors: Kotian Prem , Nayak. U Keerthan Ranga , Annappa Rajendra , Joe C. Varghese , Sujir Premjit Rabindra , Tripathi Anshul , Thaleppady Megha 
Published: January 2024

Abstract

Purpose:
In comparison to magnetic resonance imaging (MRI) imaging, this study compares the diagnostic efficacy of meniscal injury with clinical examination tests such the McMurray’s test, Thessaly test, and joint line tenderness.

Methodology:
Two hundred and fifteen patients having a history of knee injuries with symptoms such as pain, instability, and locking were studied from June 2020 to June 2022 at our institution, for a 2-year period.

Results:
The sensitivity and specificity of McMurray’s test for medial meniscus were 84% and 84.21%, respectively. The sensitivity and specificity for medial joint line tenderness were 88.15% and 55.55%, respectively. Thessaly’s test for the medial meniscus was 92.10% sensitive and 88.8% specific. The sensitivity and specificity of MRI for medial meniscal injury were 94.87% and 93.75%, respectively. McMurray’s test for lateral meniscus had a sensitivity of 84.44% and a specificity of 76.92%. Lateral joint line tenderness for lateral meniscus had a sensitivity of 86.95% and a specificity of 66.66%. The sensitivity and specificity of Thessaly’s test for lateral meniscus were 93.33% and 84.61%, respectively. MRI revealed a sensitivity of 93.75% and a specificity of 90% for lateral meniscus injuries.

Conclusion:
Even though MRI is a precise and noninvasive method for detecting meniscal injuries, a thorough clinical examination by a skilled physician has the same diagnostic power as MRI to rule out meniscal injuries. In contrast to previous tests, the Thessaly test can be used as a useful tool to detect meniscal injuries, as we discovered in our study.
Megaprosthesis Elbow Replacement in Chronic Nonunion of Distal Humeral Fracture
Authors: Chowdhury Plaban Nath , Vaish Abhishek , Vaishya Raju 
Published: January 2024

Abstract
Megaprosthesis replacement of the joints is mainly indicated to manage the bone defects caused by the excision of malignant tumors. Megaprosthesis replacement of the elbow is comparatively less done as compared to the knee joint. In posttraumatic sequelae of elbow injuries like chronic nonunion of distal humeral fracture with bone defects, the megaprosthesis replacement of the elbow can be a viable option to restore the function and stability of the elbow. We present here a case of chronic nonunion of the distal humerus managed successfully by megaprosthesis replacement of the elbow.
Cost-effective External Keel SACH Foot for Syme’s Prosthesis
Authors: Pataniak Rakesh , Kumari Rani 
Published: January 2024

Abstract

Background:
The prosthetic management of Syme’s amputation is a challenge when it comes to the attachment of SACH foot. SACH foot is made up of small narrow wooden keel which is covered by soft flexible sponge rubber therefore it is difficult to attach SACH foot directly to the Syme’s socket. Moreover, there is no rigid structure of the SACH foot available for bonding with the laminated socket considering the Syme’s amputee.

Aim:
This new design of prosthetic foot provide easy attachment to the Syme’s socket, thus helping in the prosthetic management of Syme’s amputation.

Methodology:
We have developed this Syme’s prosthetic foot with polyurethane rigid foam block, balata cloth, high-density Ethaflex, wooden block, and microcellular rubber. The design and dimensions of the prosthetic foot were decided such that it helps in easy attachment to the Syme’s prosthesis.

Results:
The attachment of this new Syme’s foot to the laminated socket has made the fabrication procedure of the Syme’s prosthesis more easy. The amputee also should improvement in cadence and more natural gait with this design.

Conclusion:
The Syme’s foot design provides natural gait in addition to the reduction of energy expenditure. This foot can also be used for transtibial prosthesis in addition to Syme’s prosthesis.
Investigation of Serum Trace Element Levels of Nigerian Women at a Late Stage of Pregnancy
Authors: Joseph Gregory Uchechukwu , Oyediran Oyewale Thomas , Oladiti Rashidat Abidemi , Iyanda Ayobola Abolape 
Published: January 2024

Abstract

Introduction:
Minerals such as selenium, zinc, copper, and manganese often referred to as antioxidant trace elements have been recognized as modulators of oxidative stress-induced conditions. Due to this very crucial function, their constant monitoring during gestation is not only encouraged but desirable.

Aim:
The study aims to evaluate serum levels of Zn, Cu, Mn, and Se during gestation.

Materials and Methods:
Forty third-trimester pregnant women (29 weeks to term) attending antenatal clinics at maternity centers within the Osogbo metropolis as well as 40 apparently healthy women, age matched, and nonpregnant that served as controls were participants for the study. Serum obtained from 5 mL of blood was used for the elemental study (inductive computerize plasma emission spectrometry). Data were analyzed using Student’s t-test and Pearson’s correlation coefficient. The level of statistical significance was P < 0.05.

Results:
Concentrations of serum trace elements (Zn, Mn, and Cu) levels were significantly lower, but selenium was significantly higher in pregnant women compared to the control group. Correlation results revealed a relationship only between copper and manganese.

Conclusion:
The results of this study showed that Nigerian pregnant women in the Osogbo metropolis are at risk of zinc, copper, and manganese depletions. This suggests that both the fetus and pregnant mother may be susceptible to oxidative stress-induced conditions.
Physiotherapeutic Approaches in Thumb Carpometacarpal Joint Arthritis for Pain, Function, and Grip Strength
Authors: Jeevrajani Jeel Mahendrabhai , Sheth Megha 
Published: January 2024

Abstract
Thumb carpometacarpal joint osteoarthritis (CMC OA) is a common condition characterized by chronic progressive degeneration of the joint cartilage. Patients present with complaints of pain at the base of the thumb, morning stiffness, and muscle weakness, all of which impair hand function and thus interfere with activities and social participation. Grip and lateral pinch movements are most affected and have a direct impact on independence, self-care, and leisure activities. This review’s objective is to find physical therapy techniques for patients with thumb CMC OA’ and their effect on pain, function, grip strength, and quality of life. Databases searched were Google Scholar, PubMed, and ScienceDirect with keywords CMC arthritis, OA, function, and physiotherapy. Articles published in the last 5 years, in the English language, randomized controlled trials, controlled trials, prospective studies, or systemic reviews were included. Duplicate and nonrelevant articles, case reports, and noncontrolled trials were excluded. Thirteen articles were found of which five articles were included. Prefabricated CMC-metacarpophalangeal immobilization splint, proprioceptive exercises, and ischemic compression over myofascial trigger points in the first dorsal interossei, first dorsal interossei strengthening, and a self-management program called OA thumb-based therapy trial has shown an effect on pain, pinch strength, grip strength, and quality of life. Additional treatments can be used along with conservative treatment for better results in reducing pain, improving grip strength, function, and quality of life in patients with CMC joint arthritis. Utilizing these methods can enhance clinical practice interventions in the management of thumb CMC joint arthritis.
The Effect of Filmed Modeling by Cartoon Character on Anxiety of Children during Pit and Fissure Sealant Application under Rubber Dam Isolation: A Randomized Controlled Trial
Authors: Dhillon Steffi , Deshpande Anshula Neeraj , Poonacha K. S. , Bargale Seema , Macwan Chirag , Jaiswal Vidhi 
Published: January 2024

Abstract

Aim:
The aim of this study was to assess the impact of filmed modeling by cartoon character on the anxiety of children during pit and fissure sealant application under rubber dam isolation.

Methodology:
The study consisted of a total of 36 children who were randomly allotted to interventional and control groups by flip-coin method. A prerecorded audio-visual film of a cartoon character getting the treatment done was shown to children included in the interventional group. The anxiety level was checked before and after the application of pit and fissure sealant using the Modified Child Dental Anxiety Scale.

Results:
Pearson’s Chi-square tests and Wilcoxon sign-ranked test were applied for statistical analysis (P < 0.5), wherein statistically significant changes in anxiety level were observed among children following the filmed modeling.

Conclusion:
Film modeling is an efficient technique to manage 7–9-year-old children’s anxiety as well as to instill positive behavior during dental treatment.
Tensile strength and elastic modulus of gutta-percha cones disinfected with sodium hypochlorite at different immersion times: An in vitro comparative study
Authors: Bellido-Guzmán Rolando , Ladera-Castañeda Marysela , Castro-Pérez Vargas Antonieta M , López-Gurreonero Carlos , Cornejo-Pinto Alberto , Aliaga-Mariñas Ana , Cervantes-Ganoza Luis A , Cayo-Rojas César F 
Published: January 2024

Abstract

Aim:
The tensile strength and modulus of elasticity of gutta-percha cones can be chemically altered due to disinfectant solutions. Therefore, the aim of the present study was to compare tensile strength and elastic modulus of gutta-percha cones subjected to sodium hypochlorite (NaOCl) disinfection at different times.

Materials and Methods:
This in vitro and longitudinal experimental study consisted of 45 gutta-percha cones, divided equally into three groups: Group 1 (disinfection with 2.5% NaOCl), Group 2 (disinfection with 5.25% NaOCl), and control group. All groups were subdivided according to immersion times for 1, 5, and 10 minutes. Tensile strength and elastic modulus were measured with a universal testing machine. For comparing more than two independent groups, parametric analysis of variance test with Sheffe’s post hoc was used and for multivariate analysis, and multivariate analysis of variance test based on Pillai’s Trace was used. In all statistical analysis, a significance level P ≤ 0.05 was considered.

Results:
When comparing the tensile strength of gutta-percha cones, no significant differences were observed after being immersed at 1, 5, and 10 minutes in NaOCl 2.5% (P = 0.715) and 5.25% (P = 0.585). Regarding the elastic modulus, a significant decrease (P < 0.05) was observed in those that were immersed in NaOCl 2.5% and 5.25% for 1, 5, and 10 minutes. Furthermore, increased NaOCl concentration significantly reduced the elastic modulus (P < 0.001). However, there were no significant differences in tensile strength (P > 0.05) and elastic modulus (P > 0.05), when evaluating the interaction between NaOCl concentration and time.

Conclusion:
Increasing NaOCl concentration significantly reduced the modulus of elasticity without affecting the tensile strength of gutta-percha cones, regardless of immersion time. Furthermore, the interaction of time and NaOCl concentration did not significantly affect the tensile strength and elastic modulus.
A bibliometric analysis of most cited papers on vesiculobullous oral lesions
Authors: Gopinathan Pillai Arun , Aboalela Ali , Haq Ikram U , Iyer Kiran , Siddeeqh Salman , Khan Sulthan R , Abbiramy Gopala Krishnan 
Published: January 2024

Abstract

Introduction:
A well-known method for quantitatively evaluating scholarly work is bibliometric analysis. Best-cited papers raise awareness of the influential publications and patterns in the literature on a specific subject. The objective was to conduct bibliometric analysis to determine most cited articles on vesiculobullous oral lesions. This is the first study on citation analysis with respect to vesiculobullous oral lesions.

Materials and Methods:
A retrospective data search was explored on December 2022 using the Scopus database. The articles were evaluated, and fundamental data for bibliometric analysis was reviewed. Standard details about the author, linked organizations, publishing year, and place of origin were noted. Statistical analysis was performed using Chi-square analysis. VOSviewer software was used to determine the bibliometric network analysis for co-occurrence among coauthors and commonly used keywords.

Results:
A total of 344 articles published from 1971 to 2022 were included in the study. A total of 6680 citations and 19.41 citations per article were observed. The journal Archives of Dermatology received the most citation. There was a significant association between the number of citations and the journal type (open access vs. non-open access) (P < 0.05). Four to five highly related clusters with the help of VOSviewer software were found during co-occurrence network analysis.

Conclusion:
The top 10 articles on vesiculobullous oral lesions that received the most citations were listed in detail in the present study. This will be a valuable resource for academics, clinicians, and researchers in the fields of dermatology, general pathology, oral pathology, and oral medicine.
Intermediate-term outcome of Aurolab aqueous drainage implant in refractory glaucoma
Authors: Mittal Shanu , Pegu Julie , Daga Darshana , Dubey Suneeta 
Published: January 2024

Abstract

PURPOSE:
The purpose of the study was to evaluate the intermediate-term outcomes of Aurolab aqueous drainage implant (AADI) in terms of intraocular pressure (IOP) lowering from baseline levels, the number antiglaucoma medications (AGMs) in the postoperative phase, and the rate of complications.

METHODS:
It was a retrospective interventional case series. All patients who underwent AADI surgeries with sulcus fixation from March 2018 to September 2018 at a tertiary eye care hospital in North India with a minimum follow-up of 1 year were recruited for the study. A standard AADI technique was employed. The primary outcome measures were the postoperative IOP, the requirement of AGMs, and early and late postoperative complications.

RESULTS:
A total of 20 patients were recruited in the study. The mean follow-up period was 25.25 ± 3.76 months. The mean IOP reduced from 33.20 ± 7.95 mmHg to 19.45 ± 9.19 mmHg at day 1, 13.62 ± 3.92 mmHg at 6 months, 12.78 ± 3.36 mmHg at 1 year, and 13.0 ± 2.53 mmHg at 2 years postoperatively (P < 0.001). The mean number of AGMs also reduced from 3.7 ± 0.97 to 0.35 ± 0.81 at 6 months, 0.42 ± 0.83 at 1 year, and 0.26 ± 0.73 at 2 years postoperatively (P < 0.001). Early postoperative complications, such as hypotony and hyphema, were seen in 5 (25%) patients, although none of them was sight-threatening. Late postoperative complications, such as hypertensive phase and persistent fibrinous membrane, were also seen in five eyes.

CONCLUSION:
The study assessed the clinical outcomes, safety profile, and long-term AGM requirement with AADI and found it to be a good viable surgical option in refractory glaucoma.
Full-field electroretinography – when do we need it?
Authors: Khan Arif O. 
Published: January 2024

Abstract
Multimodal imaging and genetic testing allow sophisticated assessment of suspected inherited retinal disease. Given the availability of such technology, some question whether the full-field electrogram (ffERG) is needed anymore. In fact, a ffERG remains essential for certain clinical scenarios. The goal of this case-based review is to provide a clear understanding of what clinical situations warrant a ffERG. All practicing ophthalmologists should be familiar with this information.
Unique phenotypic–genotypic correlation in Saudi patients with ALMS1 mutations
Authors: Almoallem Basamat M. 
Published: January 2024

Abstract
Mutations in the ALMS1 gene have been linked to isolated inherited retinal dystrophy or Alström syndrome. This report illustrates the unique pattern of ALMS1-associated diseases in a set of three simplex Saudi patients originating from unrelated consanguineous families. A detailed ophthalmological assessment was performed at the Department of Ophthalmology at King Saud University, Riyadh, Saudi Arabia. Next-generation sequencing vision panel revealed recessive ALMS1 mutations (reference sequence NM_015120). As a result, three distinct pathogenic ALMS1 mutations were identified; the first one is a nonsense mutation (c.8158C>T: p.R2720X) which has recently been identified in a Chinese patient, while the other two are known to have a founder effect in the Saudi population (the frameshift: C.848dupA: p.E283fs and the splicing: C.11870-2A>T: p.?). Clinically, a prominent nerve fiber layer was observed in the three studied patients with variable expectations of vessel attenuation. In addition, two of our patients observed unusual presentation of specific retinal pigment epithelium pigmentations in semi/halo-arrangement around the macula. Thus far, our report expands the phenotypic–genotypic spectrum of ALMS1-associated diseases and supports the principles of applying precision medicine in Saudi Arabia by utilizing the fact that common founder mutations were identified and unique phenotype was observed.
Spherical equivalent pre- and post-implantable collamer lens implantation in patients with myopia, hyperopia, and stable keratoconus
Authors: Alabbasi Omar M. , Vargas Jose , Al Mutlak Mohammed , Fairaq Rafah , Al Saleh Ahmed 
Published: January 2024

Abstract

PURPOSE:
Refractive errors are common in Saudi Arabia and keratorefractive surgeries are usually done to correct them. However, not all patients are fit and complications postoperatively are a concern. Implantable collamer lens (ICL) implantation can be used for patients who are not fit for keratorefractive surgeries. ICL can also be used for keratoconus. We elected to evaluate the outcomes of patients who had ICL implantation for refractive errors or keratoconus.

METHODS:
We retrospectively reviewed patients aged between 21 and 45 years old, who attended the anterior segment clinic at King Khaled Eye Specialist Hospital and who had spherical equivalent (SE) ranging between (+16 to −23 diopters), and had ICL implantation between February 2015 and September 2017. The SE was documented before and after the surgery. Depending on the SE, patients were divided into two groups (myopia and hyperopia). Statistical analysis was done to evaluate the change in mean SE before and after surgery for patients.

RESULTS:
We identified 169 eyes and 155 (92%) were myopic before the surgery. Before surgery, the mean SE was −8.6 and the standard deviation (SD) was 4.4. Only 14 eyes (8%) were hyperopic before the surgery with a mean SE of +5.5 and SD of 4.8. The difference in the mean of SE between after and before the surgery for myopic eyes was statistically significant (mean difference: 7.8, SD: 5, P < 0.0001). The difference in the mean of SE between post- and pre-operatively was also significant for hyperopic eyes (mean difference: −6.1, SD: 5.2, P = 0.0007). In 32 eyes with keratoconus, the mean SE before surgery was −7.9 with an SD of 4.1. For the keratoconus eyes, the mean difference of SE between after and before surgery was statistically significant as the mean difference in SE was 7.2 with an SD of 4.6 (P < 0.0001).

CONCLUSION:
The effect of ICL implantation was significant in improving the SE for myopic, hyperopic, and keratoconus eyes.
Presumed uremic optic neuropathy in a patient with Senior–Loken syndrome
Authors: Khan Arif O. 
Published: January 2024

Abstract
A patient who had been diagnosed with infantile retinal dystrophy developed renal failure in his twenties, at which time the diagnosis was revised to Senior–Loken syndrome. He was poorly compliant. At 36 years old, he experienced a sudden drop in visual acuity in the setting of cramping and fatigue and was found to be in uremic crisis. Six months after the event and its treatment, his vision failed to improved. Optic nerve pallor was out of proportion to the retinal dystrophy, and the presumed reason for his new visual loss was uremic optic neuropathy. The patient’s younger sister also had been diagnosed with infantile retinal dystrophy, and metabolic screening confirmed subclinical renal dysfunction that was to be carefully followed going forward. Infantile retinal dystrophy can be associated with later systemic disease. Early detection of such disease can potentially decrease morbidity. Patients with retinal dystrophy can develop new visual loss from causes other than the retinopathy itself.
Retinitis pigmentosa GTPase regulator-related retinopathy and gene therapy
Authors: Wongchaisuwat Nida , Amato Alessia , Lamborn Andrew E. , Yang Paul , Everett Lesley , Pennesi Mark E. 
Published: January 2024

Abstract
Retinitis pigmentosa GTPase regulator (RPGR)-related retinopathy is a retinal dystrophy inherited in a X-linked recessive manner that typically causes progressive visual loss starting in childhood with severe visual impairment by the fourth decade of life. It manifests as an early onset and severe form of retinitis pigmentosa. There are currently no effective treatments for RPGR-related retinopathy; however, there are multiple clinical trials in progress exploring gene augmentation therapy aimed at slowing down or halting the progression of disease and possibly restoring visual function. This review focuses on the molecular biology, clinical manifestations, and the recent progress of gene therapy clinical trials.
Gene therapy in bestrophinopathies: Insights from preclinical studies in preparation for clinical trials
Authors: Amato Alessia , Wongchaisuwat Nida , Lamborn Andrew , Schmidt Ryan , Everett Lesley , Yang Paul , Pennesi Mark E. 
Published: January 2024

Abstract
The BEST1 gene encodes bestrophin-1, a homopentameric ion channel expressed in the retinal pigment epithelium (RPE), where it localizes to the basolateral plasma membrane. Pathogenic variants in this gene can cause different autosomal dominant and recessive inherited retinal diseases (IRDs), collectively named “bestrophinopathies.” These disorders share a number of clinical and molecular features that make them an appealing target for gene therapy. Clinically, bestrophinopathies are often slowly progressive with a wide window of opportunity, and the presence of subretinal material (vitelliform deposits and/or fluid) as a hallmark of these conditions provides an easily quantifiable endpoint in view of future clinical trials. From a molecular standpoint, most BEST1 pathogenic variants have been shown to cause either loss of function (LOF) of the protein or a dominant-negative (DN) effect, with a smaller subset causing a toxic gain of function (GOF). Both LOF and DN mutations may be amenable to gene augmentation alone. On the other hand, individuals harboring GOF variants would require a combination of gene silencing and gene augmentation, which has been shown to be effective in RPE cells derived from patients with Best disease. In this article, we review the current knowledge of BEST1-related IRDs and we discuss how their molecular and clinical features are being used to design novel and promising therapeutic strategies.