bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR)
Authors: Mishra Nishant K , Kwan Patrick , Tanaka Tomotaka , Sunnerhagen Katharina S , Dawson Jesse , Zhao Yize , Misra Shubham , Wang Selena , Sharma Vijay K , Mazumder Rajarshi , Funaro Melissa C , Ihara Masafumi , Nicolo John-Paul , Liebeskind David S , Yasuda Clarissa L , Cendes Fernando , Quinn Terence J , Ge Zongyuan , Scalzo Fabien , Zelano Johan , Kasner Scott E 
Published: November 2023

IntroductionDespite significant advances in managing acute stroke and reducing stroke mortality, preventing complications like post-stroke epilepsy (PSE) has seen limited progress. PSE research has been scattered worldwide with varying methodologies and data reporting. To address this, we established the International Post-stroke Epilepsy Research Consortium (IPSERC) to integrate global PSE research efforts. This protocol outlines an individual patient data meta-analysis (IPD-MA) to determine outcomes in patients with post-stroke seizures (PSS) and develop/validate PSE prediction models, comparing them with existing models. This protocol informs about creating the International Post-stroke Epilepsy Research Repository (IPSERR) to support future collaborative research.Methods and analysisWe utilised a comprehensive search strategy and searched MEDLINE, Embase, PsycInfo, Cochrane, and Web of Science databases until 30 January 2023. We extracted observational studies of stroke patients aged ≥18 years, presenting early or late PSS with data on patient outcome measures, and conducted the risk of bias assessment. We did not apply any restriction based on the date or language of publication. We will invite these study authors and the IPSERC collaborators to contribute IPD to IPSERR. We will review the IPD lodged within IPSERR to identify patients who developed epileptic seizures and those who did not. We will merge the IPD files of individual data and standardise the variables where possible for consistency. We will conduct an IPD-MA to estimate the prognostic value of clinical characteristics in predicting PSE.Ethics and disseminationEthics approval is not required for this study. The results will be published in peer-reviewed journals. This study will contribute to IPSERR, which will be available to researchers for future PSE research projects. It will also serve as a platform to anchor future clinical trials.Trial registration numberNCT06108102
Changes in head staff members in male elite-level football teams are associated with increased hamstring injury burden for that season: the UEFA Elite Club Injury Study
Authors: Ekstrand Jan , Van Zoest Wart , Gauffin Håkan 
Published: November 2023

ObjectiveTo evaluate whether a change of head coach or other head staff before or during a season is correlated to hamstring injury (HI) burden in male elite-level football (soccer) in Europe.MethodsThe survey was conducted using a questionnaire reporting any staff change within the team. Data about the head staff changes and hamstring injury burdens were collected from 14 teams participating in the Elite Club Injury Study (ECIS) during the 2019/2020, 2020/2021 and 2021/2022 seasons.ResultsOn average, replacing the head coach before or during a season happens in every second season. All changes, except for the change of the head coach during a season, indicate an association with an increase in HI burden (ranging from 10% to 81%). However, only changes in the fitness coach and team doctor roles reached statistical significance. The HI burden seems to be influenced by adding new staff members, such as the head of fitness/performance coach in 36% of the teams and the team doctor in 17%. New head coaches starting the season with their own, for the team new, fitness/performance coach was highly associated with increased HI burden (p<0.001).ConclusionsBringing their own fitness/performance coaches is common for managers entering a new elite male football club. However, this paper has highlighted that this trend seems to lead to a three times increase in HI burden. Similarly, replacing the team doctor was also associated with increased HI burden. Instability among head staff members in male elite-level football teams seems associated with increased HI burden during the season.
Sport specialisation and performance-enhancing substance use by young athletes
Authors: McNaughton Michael , Hunt Danielle L , O'Brien Michael , Sugimoto Dai , Meehan William P , Miller Patricia , Stracciolini Andrea 
Published: November 2023

ObjectivesTo investigate the association of reported legal performance enhancing substance (PES) use and consideration of banned PES use among sport-specialised and non-sport-specialised young athletes.Methods and designCross-sectional study of 1049 young athletes enrolled in an injury prevention programme from 2013 to 2020. We used logistic regression modelling to determine the independent association between sports specialisation. We reported (1) legal PES use and (2) consideration of banned PES use after adjusting for the effects of gender, age, having a relative as a coach, unrestricted internet access, use of a weight training regimen, and weeknight hours of sleep.ResultsThe final cohort consisted of 946 athletes with a mean age of 14. 56% were female, and 80% were sport-specialised athletes. 14% reported legal PES use, and 3% reported consideration of banned PES use. No difference was found between sport-specialised athletes who reported legal PES use (OR=1.4; 95% CI 0.81 to 2.43; p=0.23) or consideration of banned PES use (OR=3.2; 95% CI 0.78 to 14.92; p=0.1) compared with non-sport-specialised athletes. Reported legal PES use was more common among athletes who were male, older, used weight training, and slept less. Reported consideration of banned PES use was more common among male and older athletes.ConclusionsPES use is not independently associated with sport specialisation in young athletes. Athlete sex, age, training, and sleep patterns are important factors for young athletes to consider in PES use.
The international variability of surgery for rectal prolapse
Authors: Kelley Jesse K , Hagen Edward R , Gurland Brooke , Stevenson Andrew RL , Ogilvie James W 
Published: November 2023

ObjectiveThere is a lack of consensus regarding the optimal approach for patients with full-thickness rectal prolapse. The aim of this international survey was to assess the patterns in treatment of rectal prolapse.DesignA 23-question survey was distributed to the Pelvic Floor Consortium of the American Society of Colorectal Surgeons, the Colorectal Surgical Society of Australia and New Zealand, and the Pelvic Floor Society. Questions pertained to surgeon and practice demographics, preoperative evaluation, procedural preferences, and educational needs.SettingElectronic survey distributed to colorectal surgeons of diverse practice settingsParticipants249 colorectal surgeons responded to the survey, 65% of which were male. There was wide variability in age, years in practice, and practice setting.Main outcome measuresResponses to questions regarding preoperative workup preferences and clinical scenarios.ResultsIn preoperative evaluation, 19% would perform anorectal physiology testing and 70% would evaluate for concomitant pelvic organ prolapse. In a healthy patient, 90% would perform a minimally invasive abdominal approach, including ventral rectopexy (56%), suture rectopexy (31%), mesh rectopexy (6%) and resection rectopexy (5%). In terms of ventral rectopexy, surgeons in the Americas preferred a synthetic mesh (61.9% vs 38.1%, p=0.59) whereas surgeons from Australasia preferred biologic grafts (75% vs 25%, p<0.01). In an older patient with comorbidities 81% would perform a perineal approach. Procedure preference (Delormes vs Altmeier) varied according to location (Australasia, 85.9% vs 14.1%; Europe, 75.3% vs 24.7%; Americas, 14.1% vs 85.9%). Most participants were interested in education regarding surgical approaches, however there is wide variability in preferred methods.ConclusionThere is significant variability in the preoperative evaluation and surgery performed for rectal prolapse. Given the lack of consensus, it is not surprising that most surgeons desire further education on the topic.
Cardiac coronary tomography angiography (CCTA) use across geographical regions in the USA and the UK: a cross-sectional study
Authors: Banashefski Bryana , Ji Robin , Dhruva Sanket S. , Neuhaus John , Redberg Rita F 
Published: November 2023

ObjectiveIncreased use of CT imaging has been identified as a key component of unsustainable rising healthcare costs in the USA and globally. Understanding evidence and its relation to imaging coverage policies can help identify patterns of variation to better inform high value care initiatives. This cross-sectional study evaluates regional differences in US utilisation of cardiac coronary tomography angiography (CCTA) and compares use in the USA and England.DesignWe determined differences in CCTA order rates by US Medicare region and compared order rates in the US and England, compared CT scanner prevalence in the USA and UK, and reviewed the CCTA coverage policies for each region.SettingThe US and the UK.ParticipantsMedicare Coverage Database; Medicare 2018 Part B data; National Health Services 2018 data.InterventionsCCTA orders, CT scanner prevalence.Main outcome measuresCCTA orders per beneficiary, CT scanner prevalence, CCTA policy variation.ResultsWe found that CCTA coverage policies are more permissive in the UK compared with the USA. However, CT scanner prevalence per beneficiary is four times greater in the USA than the UK. There was significant variation in number of CCTA ordered per 100 000 beneficiaries between regions in England and the USA, ranging from 74 to 313 in the US and 57–317 in England.ConclusionsThere is significant geographical variation in use of CCTA in both the USA and England, although overall use does not differ significantly between both countries. Similarities in order rates, despite a much higher CT scanner density in the USA, may be related to more permissive guidelines around use of CCTA in the UK. Variation in both countries may also reflect the lack of high-quality clinical outcomes data for use of CCTA, underscoring opportunities for more evidence and evidence-based policy to promote appropriate use of CCTA imaging.
Health-related quality of life among adolescents with type 1 diabetes since the second wave of the COVID-19 pandemic in Germany
Authors: Framme Juliane Regina , Kim-Dorner Su-Jong , Heidtmann Bettina , Kapellen Thomas Michael , Lange Karin , Kordonouri Olga , Saßmann Heike 
Published: November 2023

ObjectiveThe COVID-19 pandemic had an impact on everyday life and in general, reduced the health-related quality of life (HRQoL) of adolescents. In this study, we assess the HRQoL of adolescents with type 1 diabetes (T1D) in Germany since the second wave of the COVID-19 pandemic by using self-report and parent-proxy reports, to identify risk factors, to compare to peers and to examine the agreement of HRQoL between parents and their children.MethodsA total of 445 adolescents (12–18 years) and 413 parents participated in an anonymous cross-sectional survey conducted at three German diabetes centres from January 2021 to June 2022. Inclusion criteria were diabetes duration ≥1 year and German-speaking. Teen HRQoL was assessed by using self-report and parent-proxy report versions of the KIDSCREEN-10 index.ResultsThe majority of adolescents reported average (75.5%) HRQoL. Approximately 11.3% of teens reported high and 13.2% low HRQoL. Teen’s female gender, older age, higher diabetes burden and parental depression symptoms contributed to lower self-reported HRQoL among teens. For parent-proxy reports, increasing diabetes burdens, parental depression symptoms, non-migrant status, high education and ketoacidosis contributed to lower scores on teen HRQoL. The mean scores of the KIDSCREEN-10 index for adolescents did not differ from the German norm. In comparison to healthy peers during the first wave of the pandemic, adolescents in the current study reported higher HRQoL. The overall teen-parent agreement was fair although parents reported significantly lower teen HRQoL than adolescents did.ConclusionsHRQoL of most adolescents with T1D during the COVID-19 pandemic was average with parents reporting significantly lower scores. Self-reported and parent-proxy-reported HRQoL and the level of agreement due to different perspectives can provide important information for clinical care and intervention planning.
Mechanical thrombectomy for the treatment of primary and secondary anterior cerebral artery occlusions: insights from STAR
Authors: Dabhi Nisha , Kumar Jeyan Sathia , Ironside Natasha , Kellogg Ryan T , Sowlat Mohammad-Mahdi , Uchida Kazutaka , Maier Ilko , Al Kasab Sami , Jabbour Pascal , Kim Joon-tae , Wolfe Stacey Q , Rai Ansaar , Starke Robert M , Psychogios Marios-Nikos , Samaniego Edgar A , Arthur Adam S , Yoshimura Shinichi , Cuellar Hugo , Howard Brian M , Alawieh Ali , Romano Daniele G , Tanweer Omar , Mascitelli Justin , Fragata Isabel , Polifka Adam J , Osbun Joshua W , Crosa Roberto Javier , Matouk Charles , Levitt Michael R , Brinjikji Waleed , Moss Mark , Dumont Travis M , Williamson Richard , Navia Pedro , Kan Peter , De Leacy Reade , Chowdhry Shakeel A , Ezzeldin Mohamad , Spiotta Alejandro M , Park Min S 
Published: November 2023

Background
The safety and efficacy of mechanical thrombectomy (MT) for the treatment of acute anterior cerebral artery (ACA) occlusions have not clearly been delineated. Outcomes may be impacted based on whether the occlusion is isolated to the ACA (primary ACA occlusion) or occurs in conjunction with other cerebral arteries (secondary).

Methods

We performed a retrospective review of the multicenter Stroke Thrombectomy and Aneurysm (STAR) database. All patients with MT-treated primary or secondary ACA occlusions were included. Baseline characteristics, procedural outcomes, complications, and clinical outcomes were collected. Primary and secondary ACA occlusions were compared using the Mann–Whitney U test and Kruskal–Willis test for continuous variables and the χ
2
test for categorical variables.

Results
The study cohort comprised 238 patients with ACA occlusions (49.2% female, median (SD) age 65.6 (16.7) years). The overall rate of successful recanalization was 75%, 90-day good functional outcome was 23%, and 90-day mortality was 35%. There were 44 patients with a primary ACA occlusion and 194 patients with a secondary ACA occlusion. When adjusted for baseline variables, the rates of successful recanalization (68% vs 76%, P=0.27), 90-day good functional outcome (41% vs 19%, P=0.38), and mortality at 90 days (25% vs 38%, P=0.12) did not differ between primary and secondary ACA occlusion groups.

Conclusion
Clinical and procedural outcomes are similar between MT-treated primary and secondary ACA occlusions for select patients. Our findings demonstrate the need for established criteria to determine ideal patient and ACA stroke characteristics amenable to MT treatment.
A new science of emotion: implications for functional neurological disorder
Authors: Jungilligens Johannes 
Published: November 2023

Johannes Jungilligens, PhD is a clinical neuropsychologist and affective neuroscience researcher focusing on neuropsychological and affective aspects of functional neurological disorder. Johannes is a post-doc at the Department of Neurology at the University Hospital Knappschaftskrankenhaus Bochum in Germany. After earning his PhD at Ruhr University Bochum, he was a visiting post-doc in the lab of Prof David Perez at Massachusetts General Hospital, Harvard Medical School. In his work as a clinician-researcher, he investigates the role of emotions, interoception, and metacognition in patients with functional neurological disorder using behavioral and neurobiological assessments.AbstractAcross ancient and modern times, functional neurological disorder has had a long and tumultuous history, with an evolving debate and understanding of how biopsychosocial factors (in early discussions also spiritual or supernatural elements) contribute to the manifestation of the disorder. A central issue in contemporary discussions has revolved around questioning the extent to which emotions play a mechanistic and aetiological role in functional neurological disorder. Critical in this context, however, is that this ongoing debate has largely omitted the question of what emotions are in the first place.This talk first brings together advances in the understanding of working principles of the brain fundamental to introducing a new understanding of what emotions are. Building on a recent theoretical framework (the theory of constructed emotion; Lisa Feldman Barrett), the idea of how the predictive process of emotion construction can be an integral component of the pathophysiology of functional neurological disorder is discussed. This incorporates several themes including: (i) how chronic energy dysregulation can contribute to the emergence of neuropsychiatric illness, (ii) how functional neurological symptoms can occur in the process of aberrant emotion category construction, (iii) how the roles of alexithymia and ‘panic attack without panic’ can be re-conceptualized in this framework, and (iv) how life experiences influence emotion construction.
The psychological scars of Intensive Care
Authors: Wade Dorothy 
Published: November 2023

Dr Dorothy Wade is Consultant health psychologist at Royal Free London NHS Foundation Trust. She has a PhD in health psychology and healthcare evaluation from University College London, where she is an honorary associate professor. Her clinical and research area of expertise is in psychological risk factors, outcomes and interventions in Critical Care.AbstractWhile more people survive critical illness now than ever before, their physical and psychological recovery is often poor. There is strong evidence that people suffer adverse psychological outcomes including anxiety, depression, posttraumatic stress disorder and cognitive impairment after an Intensive Care admission.Risk factors for adverse psychological outcomes include acute stress, delirium and delusional memories of the Intensive Care Unit (ICU). About half of patients suffer acute stress in the ICU. They may be in pain and undergo repeated invasive clinical interventions. The environment can be harsh, clinical and badly-lit. ICUs are frequently noisy and overcrowded, with patients and upset, grieving families in close proximity to each other. In addition, most patients become delirious, acutely confused and experience terrifying, long-lasting hallucinations and delusions.In the past decade clinical health psychologists have become increasingly involved in supporting patients clinically in the ICU, and in research to develop and evaluate psychological interventions. Clinically they have a role in psychological assessment and care of patients along the pathway from ICU admission to follow-up reviews around 3 months post ICU-discharge. Current research includes a self-management intervention to reduce anxiety, and psychology-led support to reduce delirium-related distress in the ICU.
04 Should neuropsychiatry flow both ways? Neurology inreach into psychiatric hospital
Authors: Cope Thomas E 
Published: November 2023

Objectives/AimsTo assess the utility of neurology inreach into acute psychiatric hospital wards, through the quantitative evaluation of the case series, and presentation of qualitative experiences of service users and care providers.MethodsAll consecutive referrals to a new service delivering neurology inreach to Fulbourn hospital in Cambridge were assessed over the first six months. Patients were categorised according to their primary presentation. Outcomes included whether diagnosis was clarified, whether medication was changed, and whether interventions were made that would otherwise not have occurred. Illustrative case examples are presented.ResultsThirty-five unique patients were assessed over fourteen visits (some on multiple occasions). In 94% of cases a diagnostic opinion and management plan was reached. In 63% of cases medication was changed.23% of patients presented with a combination of Parkinson’s disease and psychosis. 20% were diagnosed with a non-parkinsonian movement disorder. 14% were diagnosed with a dementia, 14% had epilepsy, and 17% had no neurological abnormality. Importantly, three patients (9%) had an autoimmune encephalitis with a demonstrable antibody.Cases are presented where neurology inreach facilitated access to treatments that would otherwise have been unavailable, such as rapid plasma exchange and a duodopa infusion pump. Psychiatric interventions such as ECT and clozapine also occurred more rapidly, because of increased diagnostic certainty.ConclusionsOverall, the service has demonstrably delivered patient and healthcare system benefits. It has also been enjoyable for the neurologist to deliver, and well received by the psychiatric inpatient teams. There have been some barriers to delivery, which are discussed, and are mainly to do with commissioning a new service and referral boundaries. Nonetheless, this has been a relatively small input a consultant time (0.5PA) to produce meaningful improvements in patient care, and reductions in length of stay. We advocate that a similar model should be rolled out by cooperation across all acute trusts delivering psychiatric and neurological care, to break down barriers between neurology and psychiatry.
09 Religiosity and risk of Parkinson’s disease in England and the USA
Authors: Otaiku Abidemi I 
Published: November 2023

Objectives/AimsParkinson’s disease (PD) is associated with low religiosity cross-sectionally. Whether low religiosity might be associated with an increased risk for developing PD is unknown.This study investigated whether low religiosity in adulthood is associated with increased risk for developing PD.MethodsA population-based prospective cohort study was conducted. Participants from the English Longitudinal Study of Aging (ELSA) and the Midlife in the United States (MIDUS) study who were free from PD at baseline (2004–2011) and completed questionnaires on self-reported religiosity, were included in a pooled analysis. Incident PD was based on self-report. Multivariable logistic regression was used to estimate odds ratios (OR) for developing PD according to baseline religiosity, with adjustment for sociodemographic characteristics, health and lifestyle factors and engagement in religious practices.ResultsAmong 9,796 participants in the pooled dataset, 74 (0.8%) cases of incident PD were identified during a median follow-up of 8.1 years. In the fully adjusted model, compared with participants who considered religion very important in their lives at baseline, participants who considered religion not at all important in their lives had a 10-fold risk of developing PD during follow-up (OR, 9.99; 95% CI, 3.28–30.36). Moreover, there was a dose-response relationship between decreasing religiosity and increasing PD risk (P<0.001 for trend). These associations were similar when adjusting for religious upbringing and when cases occurring within the first two years of follow-up were excluded from the analysis. The association was somewhat attenuated when religious practices were removed from the model as covariates, though it remained statistically significant (OR for ‘not at all important’ vs ‘very important’, 2.26; 95% CI, 1.03- 4.95) (P<0.029 for trend).ConclusionsThis longitudinal study provides evidence for the first time that low religiosity in adulthood may be a strong risk factor for developing PD.