bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of emerging digital technologies and methodologies combined with incentives on HbA1c in patients with type 2 diabetes mellitus: study protocol for a parallel, open randomized controlled trial
Authors: Zhong Shao , Jiang Jingyi , Liu Hongying , Pan Ying 
Published: February 2024

Abstract
Background
Type 2 diabetes mellitus (T2DM) is a common metabolic disease that requires long-term management and treatment. Digital intervention, as an emerging medical model, has been widely used in the treatment of T2DM patients. Behavioral economics theory provides a favorable perspective for studying the effect of digital intervention because it can reveal the decision-making mechanisms behind human behavior and provide more effective interventions for digital intervention. The purpose of this trial is to evaluate the impact of behaviorally based digital intervention on T2DM patients’ HbA1c, self-monitoring of blood glucose (SMBG) testing rate, diabetes self-efficacy, and other indicators compared to conventional treatment.

Methods
This trial is a prospective randomized controlled trial conducted at the First People’s Hospital of Kunshan City from April 1, 2023, to December 31, 2024, with a follow-up period of 3 months. The specific randomization method was established and implemented through the EDC clinical trial center’s randomization system. We will measure and collect baseline data from three groups, including Group A: digital intervention + virtual incentives + conventional treatment, Group B: digital intervention + physical incentives + conventional treatment, and Group C: conventional treatment. HbA1c, weight, SMBG testing rate, diabetes self-efficacy, and diabetes-related medical expenses will be recorded at baseline, 1 month, 2 months, and 3 months for all three groups. The Shapiro-Wilk test will be used to test for normality, and Pearson correlation analysis will be used for correlation analysis. Dropouts will be analyzed separately. Analysis of variance or exact probability calculation will be used to compare demographic data and other baseline indicators.

Discussion
This study is a novel clinical trial that integrates multiple disciplines (economics and medicine) and uses digital technology to deliver the intervention. Most published studies were offline interventions based on behavioral economics theory, but very few were on online interventions for T2DM patients. This study has both novelty and social value.

Trial registration
Chinese Clinical Trial Registry ChiCTR2300070753. Registered on 2023/04/22.
First report on the molecular phylogenetics and population genetics of Aedes aegypti in Iran
Authors: Paksa Azim , Azizi Kourosh , Yousefi Saideh , Dabaghmanesh Sorna , Shahabi Saeed , Sanei-Dehkordi Alireza 
Published: February 2024

Abstract
Background
Aedes aegypti, the primary vector of various human arboviral diseases, is a significant public health threat. Aedes aegypti was detected in Iran in 2018, in Hormozgan province, but comprehensive information regarding its genetic diversity and origin within the country remains scarce. This study aimed to determine the origin and genetic diversity of Ae. aegypti in southern Iran.

Methods
Aedes aegypti mosquitoes were collected from Bandar Abbas City, Hormozgan Province, southern Iran, between May and July 2022. Specimens were morphologically identified. Origin and assess genetic diversity were assessed based on the mitochondrial DNA-encoded cytochrome c oxidase subunit I (mtDNA-COI) gene.

Results
BLAST (basic local alignment search tool) analysis confirmed the accuracy of the morphological identification of all specimens as Ae. aegypti, with 100% similarity to GenBank sequences. Calculated variance and haplotype diversity were 0.502 and 0.00157, respectively. Among the 604 examined nucleotide sequences, only a single site was non-synonymous. Total nucleotide diversity and average pairwise nucleotides were determined as 0.00083 and 0.502, respectively. Fu and Li's D test values were not statistically significant. Strobeck’s S statistic value was 0.487, and Tajima’s D value was 1.53395; both were not statistically significant (P > 0.10).

Conclusions
Phylogenetic analysis revealed two distinct clades with minimal nucleotide differences and low haplotype diversity, suggesting the recent establishment of Ae. Aegypti in the southern region of Iran. The phylogenetic analysis also indicated an association between Ae. aegypti populations and mosquitoes from Saudi Arabia and Pakistan.

Graphical Abstract
Historic methicillin-resistant Staphylococcus aureus: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection
Authors: Benvenga Vanni , Cuénod Aline , Purushothaman Srinithi , Dasen Gottfried , Weisser Maja , Bassetti Stefano , Roloff Tim , Siegemund Martin , Heininger Ulrich , Bielicki Julia , Wehrli Marianne , Friderich Paul , Frei Reno , Widmer Andreas , Herzog Kathrin , Fankhauser Hans , Nolte Oliver , Bodmer Thomas , Risch Martin , Dubuis Olivier , Pranghofer Sigrid , Calligaris-Maibach Romana , Graf Susanne , Perreten Vincent , Seth-Smith Helena M. B , Egli Adrian 
Published: February 2024

AbstractBackgroundFew methicillin-resistantStaphylococcus aureus(MRSA) from the early years of its global emergence have been sequenced. Knowledge about evolutionary factors promoting the success of specific MRSA multi-locus sequence types (MLSTs) remains scarce. We aimed to characterize a legacy MRSA collection isolated from 1965 to 1987 and compare it against publicly available international and local genomes.MethodsWe accessed 451 historic (1965–1987) MRSA isolates stored in the Culture Collection of Switzerland, mostly collected from the Zurich region. We determined phenotypic antimicrobial resistance (AMR) and performed whole genome sequencing (WGS) using Illumina short-read sequencing on all isolates and long-read sequencing on a selection with Oxford Nanopore Technology. For context, we included 103 publicly available international assemblies from 1960 to 1992 and sequenced 1207 modern Swiss MRSA isolates from 2007 to 2022. We analyzed the core genome (cg)MLST and predicted SCCmeccassette types, AMR, and virulence genes.ResultsAmong the 451 historic Swiss MRSA isolates, we found 17 sequence types (STs) of which 11 have been previously described. Two STs were novel combinations of known loci and six isolates carried previously unsubmitted MLST alleles, representing five new STs (ST7843, ST7844, ST7837, ST7839, and ST7842). Most isolates (83% 376/451) represented ST247-MRSA-I isolated in the 1960s, followed by ST7844 (6% 25/451), a novel single locus variant (SLV) of ST239. Analysis by cgMLST indicated that isolates belonging to ST7844-MRSA-III cluster within the diversity of ST239-MRSA-III. Early MRSA were predominantly from clonal complex (CC)8. From 1980 to the end of the twentieth century, we observed that CC22 and CC5 as well as CC8 were present, both locally and internationally.ConclusionsThe combined analysis of 1761 historic and contemporary MRSA isolates across more than 50 years uncovered novel STs and allowed us a glimpse into the lineage flux between Swiss-German and international MRSA across time.
Post-treatment surveillance imaging in head and neck cancer: a systematic review
Authors: Van Hoe Stefaan , Hermans Robert 
Published: February 2024

Abstract
Background
In patients treated for head and neck cancer, imaging studies are usually obtained within 3–6 months after treatment for assessment of treatment response. After 6 months, most guidelines advocate clinical follow-up, with imaging reserved for patients with clinically suspect or equivocal findings. However, some guidelines do recommend systematic imaging surveillance, and many clinicians tend to include some type of imaging in their follow-up schemes.

Objectives
This systematic review focuses on the usefulness of routine (systematic) post-treatment imaging surveillance of head and neck cancer beyond the first 3–6-month baseline imaging study.

Methods
A systematic literature search was conducted using PubMed and Google Scholar. Additional studies were identified by reviewing reference lists. Only original studies and review papers were considered. Results obtained with systematic post-treatment surveillance imaging were compared to symptom-directed imaging and/or clinical finding-directed imaging.

Results
Five hundred twenty-one records were identified through the database search, and 44 additional records were identified through other sources. Forty-eight articles were selected for the final review.
Analysis of these records showed that almost half of cases of locoregional recurrences and/or metastases were only detected by imaging (40.9%), and the mean time of detection of recurrent or metastatic disease (11.5 months) was well beyond the period of the first post-treatment scan. Most authors reported superior results with PET-CT when compared to other imaging techniques.

Conclusion
Strong arguments were found in favor of systematic imaging surveillance in locoregional advanced head and neck cancer during at least one and preferably 2 years after treatment.

Critical relevance statement
Analysis of the selected records showed that almost half of cases of locoregional recurrences and/or metastases were only detected by imaging. This systematic review suggests that imaging may currently be underused in the post-treatment surveillance of patients with head and neck cancer.

Key points
• This systematic review focuses on the usefulness of long-term systematic imaging surveillance in patients treated for head and neck cancer.
• Analysis of 521 articles revealed that systematic imaging allowed the initial detection of locoregional recurrences and/or metastases in more than 40% of patients.
• Imaging may currently be underused in the post-treatment surveillance of patients with advanced head and neck cancer.

Graphical Abstract
Mesenchymal stem cell-derived exosomes: a promising alternative in the therapy of preeclampsia
Authors: Shi Haoran , Yang Zejun , Cui Jianjian , Tao Hui , Ma Ruilin , Zhao Yin 
Published: February 2024

AbstractPreeclampsia (PE) is a common morbid complication during pregnancy, affecting 2%-8% of pregnancies globally and posing serous risks to the health of both mother and fetus. Currently, the only effective treatment for PE is timely termination of pregnancy, which comes with increased perinatal risks. However, there is no effective way to delay pathological progress and improve maternal and fetal outcomes. In light of this, it is of great significance to seek effective therapeutic strategies for PE. Exosomes which are nanoparticles carrying bioactive substances such as proteins, lipids, and nucleic acids, have emerged as a novel vehicle for intercellular communication. Mesenchymal stem cell-derived exosomes (MSC-Exos) participate in various important physiological processes, including immune regulation, cell proliferation and migration, and angiogenesis, and have shown promising potential in tissue repair and disease treatment. Recently, MSC-Exos therapy has gained popularity in the treatment of ischaemic diseases, immune dysfunction, inflammatory diseases, and other fields due to their minimal immunogenicity, characteristics similar to donor cells, ease of storage, and low risk of tumor formation. This review elaborates on the potential therapeutic mechanism of MSC-Exos in treating preeclampsia, considering the main pathogenic factors of the condition, including placental vascular dysplasia, immunological disorders, and oxidative stress, based on the biological function of MSC-Exos. Additionally, we discuss in depth the advantages and challenges of MSC-Exos as a novel acellular therapeutic agent in preeclampsia treatment.
Complex dental wear analysis reveals dietary shift in Triassic placodonts (Sauropsida, Sauropterygia)
Authors: Gere Kinga , Nagy András Lajos , Scheyer Torsten M. , Werneburg Ingmar , Ősi Attila 
Published: February 2024

AbstractPlacodonts were durophagous reptiles of the Triassic seas with robust skulls, jaws, and enlarged, flat, pebble-like teeth. During their evolution, they underwent gradual craniodental changes from the Early Anisian to the Rhaetian, such as a reduction in the number of teeth, an increase in the size of the posterior palatal teeth, an elongation of the premaxilla/rostrum, and a widening of the temporal region. These changes are presumably related to changes in dietary habits, which, we hypothesise, are due to changes in the type and quality of food they consumed. In the present study, the dental wear pattern of a total of nine European Middle to Late Triassic placodont species were investigated using 2D and 3D microwear analyses to demonstrate whether there could have been a dietary shift or grouping among the different species and, whether the possible changes could be correlated with environmental changes affecting their habitats. The 3D analysis shows overlap between species with high variance between values and there is no distinct separation. The 2D analysis has distinguished two main groups. The first is characterised by low number of wear features and high percentage of large pits. The other group have a high feature number, but low percentage of small pits. The 2D analysis showed a correlation between the wear data and the size of the enlarged posterior crushing teeth. Teeth with larger sizes showed less wear feature (with higher pit ratio) but larger individual features. In contrast, the dental wear facet of smaller crushing teeth shows more but smaller wear features (with higher scratch number). This observation may be related to the size of the food consumed, i.e., the wider the crown, the larger food it could crush, producing larger features. Comparison with marine mammals suggests that the dietary preference of Placochelys, Psephoderma and Paraplacodus was not exclusively hard, thick-shelled food. They may have had a more mixed diet, similar to that of modern sea otters. The diet of Henodus may have included plant food, similar to the modern herbivore marine mammals and lizards.
DenMerD: a feature enhanced approach to radar beam blockage correction with edge-cloud computing
Authors: Liu Qi , Sun Jiawei , Zhang Yonghong , Liu Xiaodong 
Published: February 2024

AbstractIn the field of meteorology, the global radar network is indispensable for detecting weather phenomena and offering early warning services. Nevertheless, radar data frequently exhibit anomalies, including gaps and clutter, arising from atmospheric refraction, equipment malfunctions, and other factors, resulting in diminished data quality. Traditional radar blockage correction methods, such as employing approximate radial information interpolation and supplementing missing data, often fail to effectively exploit potential patterns in massive radar data, for the large volume of data precludes a thorough analysis and understanding of the inherent complex patterns and dependencies through simple interpolation or supplementation techniques. Fortunately, edge computing possesses certain data processing capabilities and cloud center boasts substantial computational power, which together can collaboratively offer timely computation and storage for the correction of radar beam blockage. To this end, an edge-cloud collaborative driven deep learning model named DenMerD is proposed in this paper, which includes dense connection module and merge distribution (MD) unit. Compared to existing models such as RC-FCN, DenseNet, and VGG, this model greatly improves key performance metrics, with 30.7$$\%$$
%
improvement in Critical Success Index (CSI), 30.1$$\%$$
%
improvement in Probability of Detection (POD), and 3.1$$\%$$
%
improvement in False Alarm Rate (FAR). It also performs well in the Structure Similarity Index Measure (SSIM) metrics compared to its counterparts. These findings underscore the efficacy of the design in improving feature propagation and beam blockage accuracy, and also highlights the potential and value of mobile edge computing in processing large-scale meteorological data.
Effect of betamethasone injection into the pterygomandibular space on the neurosensory disturbance after bilateral sagittal split ramus osteotomy: a pilot study
Authors: Hamad Shehab Ahmed , Khrwatany Khurshid A. Kheder , Mohammed Mustafa Rasul , Tutmayi Saeed Hameed 
Published: February 2024

Abstract
Aim
The aim of this study was to evaluate the effect of local betamethasone injection into the pterygomandibular space on postoperative neurosensory deficits.

Materials and methods
A prospective controlled clinical study was conducted on 16 patients (6 male, 10 female; mean age, 24.95 ± 9.22 years) who underwent bilateral sagittal ramus osteotomy for mandibular discrepancies. One side of each patient’s mandible was randomly selected as the control side, and the opposite side as the experimental side. On the experimental side, a solution of betamethasone (6 mg/1 ml) was injected into the pterygomandibular space after the completion of wound closure. Neurosensory tests, including light touch, two-point discrimination, direction of movement, thermal sensitivity, and pin-prick discrimination, were performed. The follow-up period ranged between 6 and 12 months, according to the particular sensory test. The Fisher exact test was used to analyse the data.

Results
The light touch sensation was abnormal in 75% of the control side and 31% of the study side, with the difference being significant (p = 0.03). However, at 6 months, all the study cases regained touch sensation, compared to 69% of the control side. No significant difference in direction movement discrimination was seen; however, at 3 months, the study side showed significantly less direction sensation (19%) compared to the control side (56%) (p = 0.02). There was no significant difference in the two-point discrimination; however, at 3 months, the study side had a significantly less abnormal two-point sensation (13%) than the control side (56%) (p = 0.02). In addition, no significant difference was noted in thermal sensitivity or pin-prick sensation.

Conclusion
Betamethasone injection into the pterygomandibular space reduces neurosensory disturbances after bilateral sagittal split ramus osteotomies nd leads to faster recovery of sensations.
The origin of lead artifacts from Novae: applications of Pb isotopes in identifying the provenance of Roman artifacts from N. Bulgaria
Authors: Recław Janusz , Sierpień Paula , Karasiński Jakub , Kamenov George , Powell Wayne , Marciniak-Maliszewska Beata , Kałaska Maciej 
Published: February 2024

Abstract
This study identifies the lead ores used to produce lead artifacts used by the Romans between the first and eighth centuries AD during the construction of the fort and then the town of Novae (N. Bulgaria). For this purpose, lead samples were taken from pipes, joints of columns and pedestals, and from a lead ingot. The samples were analyzed for lead isotopes and the results were compared to literature data for Roman mines from what is now Bulgaria, Greece, North Macedonia, Montenegro, Bosnia and Herzegovina, Italy, Germany, and Romania. Pb isotope results indicate that during the earlier stages of Novae's establishment, lead was most likely supplied from several different mines located in the Balkan area. Several samples also show Pb isotopes indicating mixing of lead from mines in the Balkan area. Then in the fourth—fifth century AD lead began to be supplied mainly from mines located in NW Bulgaria, with one sample possibly from deposits in German. This is evidenced by the matching of the results obtained for the ores to the data for deposits from these regions. Two possibly recycled samples were also identified. Deposits from other European regions did not match samples from Novae, indicating that majority of the lead was sourced from mines in the Balkan region.
Design and research of digital twin platform for handicraft intangible cultural heritage -Yangxin Cloth Paste
Authors: Li Min , Xu Shengtao , Tang Jie , Chen Wenfeng 
Published: February 2024

Abstract
In the context of the 5G era, the rapid development of digital technology and its integration with intangible cultural heritage (ICH) can facilitate the dynamic transmission of ICH.The research purposes to construct a virtual experience platform for handmade ICH using the handmade ICH of East Hubei Province in China—Yangxin Cloth Paste as a case study through Digital Twin technology. It explores the application of digital twin technology in the field of handmade ICH transmission and aids the dynamic transmission of handmade ICH. Firstly, the research collected tangible and procedural data of the Yangxin Cloth Paste. By using photogrammetric techniques, a model of the handicraft was built and an effective digital twin conversion procedure was designed. Next, the research set up a framework for a digital twin platform for handmade ICH, designing systems for the production, display, and transaction of ICH handicrafts. Lastly, its effectiveness was validated by user satisfaction evaluation guiding subsequent optimization direction. The platform innovatively uses digital twin technology to help users visualize handicraft ICH. Through the combination of digital twin technology and virtual reality technology, it creates a realistic virtual reality experience of ICH of handicraft, stimulates users' interest in exploring ICH of handicraft, and contributes to the process protection, dissemination and development of handicraft ICH.
Clinical performance of additively manufactured subperiosteal implants: a systematic review
Authors: Anitua Eduardo , Eguia Asier , Staudigl Christoph , Alkhraisat Mohammad Hamdan 
Published: February 2024

Abstract
Purpose
The aim of this study was to assess implant survival and complications rate of modern subperiosteal implants (CAD designed and additively manufactured).

Methods
A systematic review was conducted using three electronic databases; Medline (Pubmed), Cochrane library, and SCOPUS, following the PRISMA statement recommendations to answer the PICO question: “In patients with bone atrophy (P), do additively manufactured subperiosteal implants (I), compared to subperiosteal implants manufactured following traditional approaches (c), present satisfactory implant survival and complication rates (O)? The study was pre-registered in PROSPERO (CRD42023424211). Included articles quality was assessed using the “NIH quality assessment tools”.

Results
Thirteen articles were finally selected (5 cohort studies and 8 case series), including 227 patients (121 female / 106 male; weighted mean age 62.4 years) and 227 implants. After a weighted mean follow-up time of 21.4 months, 97.8% of implants were in function (5 failures reported), 58 implants (25.6%) presented partial exposure, 12 patients (5.3%) suffered soft tissue or persistent infection. Fracture of the interim prosthesis was reported in 8 of the155 patients (5.2%) in which the use of a provisional prosthesis was reported. A great heterogeneity was found in terms of study design and methodological aspects. For this reason, a quantitative analysis followed by meta-analysis was not possible.

Conclusions
Within the limitations of this study, modern additively manufactured subperiosteal implants presented a good survival in the short-time, but a noticeable number of soft-tissue related complications were reported. Further studies are needed to assess the clinical behavior in the medium- and long-term.

Graphical Abstract