bluuebunny/crossref_metadata_2025_split huggingface dataset:
The underlying mechanisms of the association of bone health with depression – an experimental study
Authors: Houtenbos Sanne Paulien , He Yangyang , Cazzanelli Petra , Soultoukis George , Wuertz-Kozak Karin , Schulz Tim J. , Wippert Pia-Maria 
Published: January 2025

Abstract

Background
Depression constitutes a risk factor for osteoporosis, but underlying molecular and cellular mechanisms are not fully understood. MiRNAs influence gene expression and are carried by extracellular vesicles (EV), affecting cell-cell communication. Aims: (1) Identify the difference in miRNA expression between depressed patients and healthy controls; (2) Analyze associations of these miRNAs with bone turnover markers; (3) Analyze target genes of differentially regulated miRNAs and predict associated pathways regarding depression and bone metabolism.

Methods and results
Blood samples from depressed patients (n = 11) were obtained from a previous study and healthy controls (n = 9) were recruited. Sociodemographic, depression diagnosis and depressive symptom (BDI-II) data were collected through questionnaires. Blood plasma was collected from each participant and real-time-quantitative PCR was performed on isolated plasma EVs; differences in miRNA expression between groups were analyzed using qbase+. Regression models assessed the associations of differentially regulated miRNAs with bone turnover markers procollagen-1 N-terminal-peptide, osteocalcin, and crosslaps; enriched pathways and miRNA target gene networks were analyzed. 19 miRNAs were differentially expressed between groups (p
< 0.05). MiR-26b-5p and miR-106a-5p showed an association with procollagen-1 N-terminal-peptide; miR-330-5p and miR-377-3p were associated with osteocalcin, and miR-26b-5p, miR-34c-3p and miR-145 with crosslaps. Pathway analysis including the differentially expressed miRNAs predicted enriched pathways, including the FoxO signaling and p53 signaling pathway. Seven target genes were identified.

Conclusions
MiRNAs (e.g. miR-26b-5p, miR-377-3p), genes (TNRC6B, HSPA8), and pathways (FoxO- and Hippo-signaling pathway) are identified which could be mediators between the influence of depression on bone health and could possibly serve as biomarkers in the treatment of bone diseases among people with mental disorders.
How Important are Carer Tasks in Determining Carer Quality of Life? Evidence from a Shapley Decomposition Approach
Authors: Candon David , Hewitt Michael , Liu-Smith Yu-Ling , Murphy Peter 
Published: January 2025

Abstract
While there is a large literature that examines the determinants of carer quality of life, there is a dearth of research that focuses on the usual activities that carers perform and how they are related to carer-specific measures of quality of life. We use data from the Survey of Adult Carers in England to investigate the role that the tasks that carers perform play in determining carer quality of life. We model the relationship between the variables through a series of simple linear regressions, multiple linear regressions, and a Shapley decomposition. We find that all of the individual tasks that we have information on are statistically significant predictors of carer quality of life. In addition, the Shapley decomposition shows that, when taken together, carer tasks explain a higher proportion of variance in carer quality of life than any other group of determinants. These results are largely robust to different measures of carer tasks, different measures of carer quality of life, and different subgroups. We also find that there is evidence of a causal link between carer tasks and carer quality of life as carers report that their caring responsibilities have affected tangible health outcomes such as illnesses and GP visits. From a policy perspective, local government services that are used to support carers should know that policies designed to help carers with their tasks could have a large impact on carer quality of life.
AuPd/TiO2 Catalysts in the CO Oxidation: Insights into the Synthesis Procedure and In-situ Spectroscopy Studies
Authors: Araiza Daniel G. , Fernández Misael , Sánchez-Ugalde Mariana , Miranda Aida , Solís-Casados Dora A. , Maturano-Rojas Viridiana , Zanella Rodolfo 
Published: January 2025

Abstract
A series of bimetallic AuPd/TiO2 catalysts (Au/Pd = 1) were prepared through either the impregnation or the deposition-precipitation in urea (DPU) approach and tested in the CO oxidation reaction. Among these, the sample synthesized through a sequential impregnation (Pd) followed by DPU (Au), with an intermediate thermal treatment in air, presented a remarkable CO conversion at sub-ambient temperatures and an enhanced catalytic stability, compared to the monometallic samples. The ex-situ characterization revealed that the synthesis procedure led to the formation of well-dispersed bimetallic AuPd nanoparticles over the TiO2 support. The in-situ characterization helped to propose that bimetallic NPs were composed of an intermetallic Au-Pd phase with both atoms available in the surface. Both in-situ FTIR and UV-vis spectroscopies helped to recognize the active sites during the reaction: Au in close interaction with the TiO2 at low temperatures, and step/edges Pd sites at high temperatures. Finally, the pivotal role of the TiO2 reducibility in the CO oxidation reaction, promoted by the bimetallic AuPd NPs, was determined through in-situ Raman spectroscopy.
Differential Myf5 and Myf6 expression and muscle fiber traits in Angora, Hair, Honamlı, and Kilis goats
Authors: Bayrak Büşra , Şen Uğur , Gökçek Dilek , Şirin Emre 
Published: January 2025

Abstract
The present study was conducted on specific skeletal muscles of six weaned male kids from each of the Angora, Hair, Honamlı, and Kilis goat breeds. The relationships between the expression of myogenic factor 5 (Myf5) and myogenic factor 6 (Myf6) genes and muscle fibre characteristics were analysed. Muscle samples from the longissimus dorsi (LD) and semitendinosus (ST) were collected from six 90-day-old weaned male kids of each breed. Muscle fiber characteristics were assessed through histochemical staining, while expression levels of Myf5 and Myf6 genes were quantified using real-time PCR. Total RNA content in the LD and ST muscles was significantly higher (p < 0.05) in Honamlı kids compared to those of the other breeds. Similarly, the expression of Myf5 gene in Honamlı kids was significantly higher (p < 0.05) than that observed in kids from the other breeds in LD muscle. Conversely, in the ST muscle, Hair kids exhibited a significantly lower expression of Myf5 (p < 0.05) when compared to both Honamlı and Kilis kids Additionally, Kilis kids demonstrated a significant reduced expression of Myf6 gene (p < 0.05) relative to the other breeds. The highest expression levels of the Myf6 gene (p < 0.05) were detected in the ST muscle of Honamlı and Angora kids, significantly surpassing those observed in Hair and Kilis kids. Moreover, significant correlations (p < 0.05) were observed among Myf5 and Myf6 gene expression levels and various muscle fiber characteristics differing across breeds. The results of this study underscore the pivotal role of these myogenic regulatory factors in muscle development, offering insights into the molecular mechanism driving breed-specific muscle growth. This association between gene expression and muscle phenotype could have profound implications for targeted breeding programs aimed at optimizing muscle traits in livestock species.
Efficacy and safety of teriparatide in kidney transplant recipients with osteoporosis and low bone turnover: a real-world experience
Authors: Vetrano Daniele , Aguanno Francesco , Passaseo Alessia , Barbuto Simona , Tondolo Francesco , Catalano Veronica , Zavatta Guido , Pagotto Uberto , La Manna Gaetano , Cianciolo Giuseppe 
Published: January 2025

Abstract

Introduction
Kidney transplantation is the preferred treatment for end-stage kidney disease (ESKD), enhancing survival and quality of life. However, kidney transplant recipients (KTRs) are at high risk for bone disorders, particularly low bone turnover disease, which increases fracture risk. Teriparatide, an anabolic agent, may provide a beneficial treatment option for these patients.

Materials and methods
This single-center, retrospective observational study involved 18 KTRs with osteoporosis, low bone turnover, and a history of vertebral or non-vertebral fractures. Patients received teriparatide (20 μg/day) for up to 2 years. Areal bone mineral density (aBMD) at the lumbar spine (LS), total hip (TH), femoral neck (FN), and trabecular bone score (TBS) were measured at baseline, 1 year, and 2 years. In addition, bone turnover markers (BTMs), serum calcium, phosphorus, parathyroid hormone (PTH), and kidney function were monitored.

Results
Significant increases in LS aBMD were observed after 1 year (0.941 ± 0.152 vs 1.043 ± 0.165, p = 0.04) and maintained after 2 years compared to baseline (0.941 ± 0.152 vs 1.074 ± 0.154, p = 0.03). TH aBMD significantly increased after 2 years (0.753 ± 0.145 vs 0.864 ± 0.141, p = 0.04), while FN and TBS showed non-significant improvement. Teriparatide was well-tolerated, with mild and transient hypercalcemia and hypophosphatemia.

Conclusion
Teriparatide significantly improved BMD at the LS and TH in KTRs with osteoporosis and low bone turnover, showing a favorable safety profile.
Modelling Water Management using SWAT+ : Application of Reservoirs Release Tables and the New Water Allocation Module in a Highly Managed River Basin
Authors: Sánchez-Gómez Alejandro , Arnold Jeffrey G. , Bieger Katrin , Čerkasova Natalja , Sammons Nancy B. , Martínez-Pérez Silvia , Molina-Navarro Eugenio 
Published: January 2025

Abstract
Incorporating the simulation of water management actions in hydrological models is paramount to enhance their reliability and usefulness. SWAT + (Soil and Water Assessment Tool) includes novelties in this aspect compared to its previous versions: the decision tables and the water allocation module provide enhanced capabilities for configuring management actions. Despite their potential, these features have not yet been applied due to their novelty. This study pioneers the use of SWAT + ’s new features applied in the Upper Tagus River Basin, a densely populated and highly regulated catchment. Irrigation, reservoir management, and various kinds of water transfers were incorporated in a SWAT + model of this basin. The implementation of management actions and their impact on the model performance were evaluated. The model accurately reproduced water demand for irrigation and water transfers, capturing both the demand volume and timing. The water sources were configured to meet most of the demand, with 73% of irrigation and 90% of water transfer requirements being satisfied. Release decision tables were configured for 31 reservoirs, resulting in an accurate simulation of outflow and storage in many of them. Incorporating management actions improved the streamflow simulation at the basin outlet, both considering the hydrograph and performance metrics (e.g., PBIAS was reduced by more than 50%). Some potential improvements in the model configuration and in the code were identified and will be addressed in future studies. This work provides a comprehensive guide to SWAT + ’s new features and the methodology employed, making it valuable for anyone working with the model.
Aging-Induced Microstructural and Property Changes in Direct Laser Energy Deposited NiCrFeSiBC Hardfacing Alloy Bushes
Authors: Haribabu S. , Sudha C. , Paul C. P. , Srihari V. 
Published: January 2025

Abstract
Wear resistant NiCrFeSiBC hardfacing alloy bushes for fast breeder reactor applications are fabricated through direct laser energy deposition (DLED) using CO2 laser with optimized parameters for laser power (2.5 kW), scan speed (4.2 mm/s), powder feed rate (4 g/min) and 60% of track to track overlap. DLED bushes have significantly different microstructure than weld deposited ones. As-deposited bushes have predominantly uniform fine dendritic solidification structure of γ-Ni + Ni3B, γ-Ni + Ni3B + Cr3C2 and Ni-B-Si eutectics with low volume fractions of Cr-rich borides and carbides. Microstructural heterogeneity is observed only in layer overlap regions characterized by coarsening of carbides that resulted in lower hardness (625 ± 11 HV0.1) compared to layer interiors (740 ± 19 HV0.1). Effect of aging at 550 °C on the microstructure and properties of the bushes is investigated using experimental and thermo-kinetic simulation techniques. Microstructure of the bushes remains stable without significant coarsening of the γ-Ni + Ni3B eutectic structures even after heat treatment for 4000 h. However, precipitation and coarsening behavior of Cr7C3 and Cr23C6 carbides are affected by aging which is reflected in the variation in hardness. Hardness of the bushes increases up to 100 h of aging due to the precipitation of fine Cr-rich carbides, and with increase in the duration of aging, carbides coarsen thereby reducing the hardness. Based on the study, it is concluded that direct laser energy deposited bushes may have better stability with respect to microstructure and properties at service temperatures.
The mediating role of mental health in the relationship between childhood experiences and social media use disorder among university students: a mixed-methods study
Authors: Bakır Vedat , Dilmaç Bülent 
Published: January 2025

Abstract
This mixed-methods study examines the impact of childhood trauma and family dynamics on mental health and the development of social media use disorder (SMUD) among university students. Through a combination of quantitative and qualitative methods, this research offers a comprehensive investigation into how early life experiences influence social media addiction and the mediating role of mental health. The independent variable is childhood experiences, the dependent variable is social media use disorder, and mental health serves as the mediating variable. The study, conducted in 2024 with a sample of 330 university students, employs correlation analysis and mediation testing, with bootstrapping used to evaluate the significance of indirect effects. The results demonstrate that mental health issues, such as depression, anxiety, and stress, mediate the relationship between childhood experiences and social media use disorder. Structural Equation Modeling (SEM) further reveals that adverse childhood experiences contribute to mental health challenges in adulthood, which in turn exacerbate social media addiction. Qualitative findings offer rich insights into how social media affects daily routines, family interactions, and psychological well-being, revealing its central role in the participants’ lives. Moreover, this study highlights how childhood experiences shape social media use patterns. These findings significantly advance the understanding of the complex interplay between early life trauma, mental health, and social media use, addressing critical gaps in the literature on digital addiction.
Production of sorbet with persimmon using green pea aquafaba: physicochemical characterization and bioaccessibility of bioactive compounds
Authors: Kilicli Mahmut , Erol Kübra Feyza , Akdeniz Esra , Toker Ömer Said , Törnük Fatih , Bayram Mustafa 
Published: January 2025

Abstract
The purpose of this study was to valorize green pea cooking water (aquafaba) as a foaming agent in sorbet samples using with persimmon. Significant amount (22.34% ±1.22) of protein was determined in GPA (green pea aquafaba) at 10 Brix as a dry basis. GPA was added to the homogeneous puree mixture in varying concentrations (2.5, – 5, – 7.5, – 10 and 15%) and sorbet was produced in ice cream machine. The results showed that protein and dietary fiber content increased with the increasing of GPA. While the L value increased with increasing of GPA, the overrun improved from 8 to 51%. According to the experimental data, the Herschel–Bulkley model was fitted to samples, and the flow behavior index values varied between 0.29 and 0.37 (R
2 > 0.97). Total phenolic content (TPC) and antioxidant activity (CUPRAC and DPPH) of the resulting sorbet samples were also determined. Moreover, bioaccessibility of phenolics and antioxidant activities were also determined using in vitro digestion. All of the bioactive parameters are positively affected at sorbet samples. Using GPA as a foaming agent improved the overrun as well as bioactive characteristics of the sorbets. It can be said that 10% GPA gives better results, especially when considering overrun and sensory evaluation.
Phytochemical, antioxidant, and antimicrobial properties of Bellardia trixago methanol and ethanol extracts: insights from ADMET and molecular docking approaches
Authors: Aytar Erdi Can , Aydın Betül , Durmaz Alper , Torunoğlu Emine Incilay 
Published: January 2025

Abstract
This study investigates the antioxidant, antimicrobial, and phytochemical properties of ethanol and methanol extracts derived from Bellardia trixago flowers alongside molecular docking and pharmacokinetic assessments of stigmasterol, a key bioactive compound. The antioxidant activities of the ethanol and methanol extracts were determined, with the methanol extract demonstrating higher activity, 0.370 ± 0.002 mg/mL, compared to the ethanol extract, 0.95 ± 0.09 mg/mL. The total phenolic content of the ethanol extract was 79.14 ± 2.30 mg GAE/g extract DW, and its flavonoid content was 244.31 ± 12.51 mg QE/g extract DW. The methanol extract contained a lower phenolic content of 51.50 ± 1.43 mg GAE/g extract DW but a higher flavonoid content of 251.67 ± 6.68 mg QE/g extract DW. The ethanol extract exhibited a superior iron chelation capacity of 8.21 ± 0.09 mg/mL relative to the methanol extract of 6.68 ± 0.28 mg/mL. Antimicrobial assays demonstrated that both extracts exhibited strong bactericidal and bacteriostatic effects, with MIC values ranging from < 0.39 mg/mL to > 125 mg/mL. The highest antimicrobial activity was observed against Bacillus cereus NRRL B-3711. Phytochemical analysis identified 25 compounds in the methanol extract and 20 in the ethanol extract. Stigmasterol was the major constituent in both extracts, accounting for 26.51% in ethanol and 12.65% in methanol. Molecular docking studies of stigmasterol revealed strong binding affinities with several protein targets, including Candida albicans Complex III2 (-8.7 kcal/mol), Escherichia coli HipBST (-7.2 kcal/mol), and the ribosomal subunit of Staphylococcus aureus (-7.0 kcal/mol). These interactions highlight stigmasterol’s potential role in modulating bacterial and fungal protein functions, emphasising the potential therapeutic applications of B. trixago, particularly in antimicrobial and antioxidant contexts.
Hydrogeochemical characterization of groundwater using water quality index and multivariate statistical analysis in Binji town and environs, Sokoto basin, Northwestern Nigeria
Authors: Abdullahi Ibrahim Mohammed , Abubakar Lawali , Saidu Garba , Yusuf Hassan 
Published: January 2025

Abstract
The hydrogeochemistry of groundwater from Binji community and surroundings was assessed. The main aim of the study was to characterize the groundwater in the study area through the application of indexing and statistical methods. Measured PH revealed 12 samples to be acidic and 15 samples to be alkaline with majority of the samples from dug wells having PH that indicates alkalinity. The concentration of analyzed chemical parameters in sampled water revealed the dominance of Ca over other metals detected in the groundwater, with the dominance given in the order Ca˃ Mg ˃ Na ˃ K. The anions were dominated by HCO3 in the order HCO3 ˃ Cl ˃ SO4 ˃ CO3. Ca ion exceeded the Nigerian standard for drinking water quality (NSDWQ) and the World Health Organization (WHO) set limits in one sample, Mg in 14 samples while K exceeded in four samples. HCO3 exceeded both standards in 21 samples; Total dissolved solids and electrical conductivity were above the maximum permissible limits in four samples. Five different water types were identified in the area with Ca + Mg- HCO3 dominating other types. Computed water quality index (WQI) for drinking water gave values that are within the range of 18–77.5 indicating the groundwater to be within the excellent and good classes of suitable drinking water quality. Irrigation water quality index revealed the groundwater to be suitable except for the magnesium hazard. Correlation analysis gave a moderate positive correlation that ranges from 0.632 to 0.659 between total hardness, Mg and HCO3, and that between Mg and HCO3 indicates the contribution of these elements to the hardness of water. Principal component analysis gave six components with a total variance of 76.19% with eigenvalues above 1 with the range of 1.52 – 4.26. Cluster analysis performed on the hydrogeochemical parameters demarcated four clusters based on the sources, hydrogeochemical environment, and reactions between chemical variables. Correlation between many chemical species revealed formation under a common hydrogeochemical environment. Gibb’s plot showed the sources of chemical constituents of groundwater to be dominated by precipitation source. The groundwater of the area is hard water that is fresh and safe for drinking and other domestic uses.
Amplification of Secondary Flow at the Initiation Site of Intracranial Sidewall Aneurysms
Authors: Csippa Benjamin , Friedrich Péter , Szikora István , Paál György 
Published: January 2025

Abstract

Purpose
The initiation of intracranial aneurysms has long been studied, mainly by the evaluation of the wall shear stress field. However, the debate about the emergence of hemodynamic stimuli still persists. This paper builds on our previous hypothesis that secondary flows play an important role in the formation cascade by examining the relationship between flow physics and vessel geometry.

Methods
A composite evaluation framework was developed to analyze the simulated flow field in perpendicular cross-sections along the arterial centerline. The velocity field was decomposed into secondary flow components around the centerline in these cross-sections, allowing the direct comparison of the flow features with the geometrical parameters of the centerline. Qualitative and statistical analysis was performed to identify links between morphology, flow, and the formation site of the aneurysms.

Results
The normalized mean curvature and curvature peak were significantly higher in the aneurysmal bends than in other arterial bends. Similarly, a significant difference was found for the normalized mean velocity (

$$p=0.0274$$

p
=
0.0274

), the circumferential (

$$p=0.0029$$

p
=
0.0029

), and radial (

$$p=0.0057$$

p
=
0.0057

) velocity components between the arterial bends harboring the aneurysm than in other arterial bends. In contrast, the difference of means for the normalized axial velocity is insignificant (

$$p=0.1471$$

p
=
0.1471

).

Conclusion
Thirty cases with aneurysms located on the ICA were analyzed in the virtually reconstructed pre-aneurysmal state by an in-silico study. We found that sidewall aneurysm formation on the ICA is more probable in these arterial bends with the highest case-specific curvature, which are accompanied by the highest case-specific secondary flows (circumferential and radial velocity components) than in other bends.