bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered Microglia‐Exosomes Coated Highly Twisting AIE Photothermal Agents to Efficiently Cross Blood‐Brain‐Barrier for Mild Photothermal‐Immune Checkpoint Blockade Therapy in Glioblastoma
Authors: Lin Xun , Sun Zhihong , Huang Shiyun , Liu Chuyao , Peng Jin , Li Yueying , Xiong Yue , Gao Hong , Chen Jianwei , Qi Junyang , Sun Chengming , Cai Lintao , Deng Guanjun , Deng Wenbin 
Published: December 2023

AbstractImmune checkpoint blockade (ICB) therapy has achieved remarkable therapeutic effects in cancer, but it is not effective in glioblastoma (GBM). The main reason is that it is difficult for drugs to penetrate blood‐brain‐barrier (BBB) to GBM and lacks enough pre‐existing cytotoxic CD8+ T cells in GBM microenvironment. Here, two AIE photothermal agents (Fs and Fo) are synthesized with NIR‐II fluorescence emission and increase molecular twisting of AIE photothermal agents by simply changing one O atom into S atom, improving Fs photothermal conversion efficiency to 48%. Subsequently, engineered microglia‐exosomes AIE nanoparticles (EE@Fs‐NPs) are prepared by encapsulating Fs with microglia‐exosomes which express immune checkpoint LAG3 inhibitory antibody (anti‐LAG3) via genetic engineering technology. Engineered microglia‐exosomes endow that EE@Fs‐NPs cross BBB and target GBM, which successfully deliver anti‐LAG3 to GBM. Anti‐LAG3 highly reverses T cells exhaustion and generates TNF‐α for inhibiting the expression of heat shock proteins to enhance tumor cells thermosensitivity. Moreover, AIE photothermal agents of EE@Fs‐NPs generate mild photothermal therapy to destroy tumor cells and improve the infiltration of cytotoxic CD8+ T cells in GBM, which increases the responsiveness of ICB therapy. EE@Fs‐NPs produce powerful mild photothermal‐immune synergistic therapeutic effect, which will provide a therapeutic platform for the efficient treatment of GBM.
Integrated Biotic–Abiotic Solar Driven NADPH Regeneration Platform in Escherichia coli for Chemical Biomanufacturing Applications
Authors: Bachar Oren , Meirovich Matan M. , Yehezkeli Omer 
Published: December 2023

AbstractThe development of a biohybrid bacterium capable of self‐synthesizing photocatalytically active quantum dots (QDs) is reported using the expression of a template protein that dictates the QDs size and properties. This biotic–abiotic light‐harvesting module is utilized for solar‐driven NADPH regeneration within the living bacteria, facilitated by controlled expression of ferredoxin NADP+ reductase. It is shown that the co‐expression of the latter is crucial for the selective production of biologically active 1,4‐NADPH. Upon irradiation, an 8.5‐fold increase in intracellular NADPH/NADP+ levels is shown, creating a pool of reducing equivalents available for reductive biocatalysis. This module is then utilized for the activation of a solar‐driven synthetic cascade by co‐expressing the NADPH‐dependent imine reductase responsible for the generation of precious chiral amines. It is shown that the addition of a diffusing redox mediator is essential for maximizing cell performance. These results present a promising route toward the development of semi‐artificial photosynthetic processes in living cells.
US agricultural exports and the 2022 Mississippi River drought
Authors: Steinbach Sandro , Zhuang Xiting 
Published: December 2023

AbstractThis paper investigates the impact of the 2022 Mississippi River drought on agricultural trade using counterfactual evaluation methods and detailed trade data at the US port level. The study examines how the drought disrupted agricultural shipments out of Louisiana ports and whether the disruption led to trade diversion to other ports. Our findings reveal that shipments out of Louisiana ports were 3.9% or $560 million below the counterfactual between July 2022 and January 2023. In addition, the dynamic treatment estimates provide evidence of immediate trade recovery after the drought receded in October 2022, indicating that the impact of the drought was short‐lived. Wheat exports were the most affected, experiencing a reduction in shipments from Louisiana ports of $150 million and being diverted to US ports on the West Coast. In contrast, corn and soybeans did not experience lasting trade destruction or diversion to other ports. Our analysis also reveals that export prices increased significantly above the counterfactual level at Louisiana ports, suggesting that the drought impacted the supply and export dynamics of agricultural commodities. In conclusion, this paper provides valuable insights into the short‐run implications of natural disasters on agricultural trade. [EconLit Citations: F14, Q17].
Unraveling Turkish agricultural market challenges: Consequences of COVID‐19, Russia–Ukraine conflict, and energy market dynamics
Authors: Urak Faruk 
Published: December 2023

AbstractFor a significant global segment, the volatility in grain prices presents a substantial menace to food accessibility and security. In the global pandemic and the Russia–Ukraine conflict (RUW), numerous nations were caught off guard, exacerbating this predicament and leading to instances where citizens faced purchasing restrictions on sunflower oil. This study employs the VAR (1)‐Asymmetric BEKK‐Generalized Autoregressive Conditional Heteroscedasticity (GARCH) (1,1) model to assess the extent of risks stemming from the pandemic and RUW in critical Turkish agricultural commodity markets: namely, wheat, barley, corn, and sunflower oil. The analysis reveals that the conditional variances of their return series are positively influenced by short‐ and long‐term uncertainties. With the escalations in the global oil market, the enduring hazards within these selected markets in Türkiye have intensified concurrently. The COVID‐19 pandemic has induced a decrease in long‐term uncertainty within wheat and barley markets, wherein noteworthy spillover risks in the barley, corn, and sunflower oil markets have exacerbated risks in the corn market. Empirical findings imply that COVID‐19 and RUW disrupt the agricultural supply chain, leading to impediments in food provisioning and security. The outcomes provide valuable insights to fortify policies, guarantee consistent access to plant‐based protein, and address nutritional insecurity within the nation. These policy measures align with the initiatives undertaken by the United Nations and Türkiye, which actively engage in establishing a grain corridor to facilitate Ukraine's grain exports, thereby ensuring food security and safeguarding agricultural lands. [EconLit Citations: A1, E3, G1, Q0, Q1, Q2, Q4].
Boosting CO2 electroreduction to HCOOH at high current density through tuning the electronic metal‐support interaction
Authors: Ning Chenjun , Wu Zhaohui , Bai Sha , Ren Jing , Li Shaoquan , Xiong Wenbo , Zheng Lirong , Zheng Jianwei , Song Yu‐Fei , Zhao Yufei 
Published: December 2023

AbstractElectrocatalytic CO2 reduction (CO2ER) to valuable chemicals, for example, HCOOH have received widespread attention, which still suffers from moderate Faradaic efficiency with low current regarding the wide industrial application of HCOOH. Herein, we employed a strategy of modifying electronic metal‐support interaction (EMSI) by fabricating Bi nanoparticles supported Ni‐modified Bi2O2CO3 (Bi/Ni‐BOC) heterostructure. The obtained Bi/Ni‐BOC exhibited high formate Faradic efficiency (FEHCOOH) of 97% at −2.1 V (vs. Ag/AgCl) and above 90% within broad potential range (−1.7 to −2.2 V) in flow cell with superior stability at high current density of ~220 mA cm−2, and formate concentration can reach 2.4 mmol h−1 cm−2 at −2.3 V. In/ex situ x‐ray absorption fine structure (XAFS) and density functional theory (DFT) calculation indicated that Ni doping promoted the enhancement of EMSI, which improved the generation and stable existence of electron‐rich Bi to boost CO2 activation and *OHCO hydrogenation, thus facilitating highly‐efficient formate production with hydrogen evolution reaction (HER) inhibition.
Assessing the conservation status of mangroves in Rakhine, Myanmar
Authors: Lee Calvin K. F. , Nicholson Emily , Duncan Clare , Grantham Hedley S. , Keith David A. , Tizard Rob , Murray Nicholas J. 
Published: December 2023

Abstract

Ecosystem degradation is a key challenge that human society faces, as ecosystems provide services that are tied to human well‐being. Particularly, mangrove ecosystems provide important services to communities but are suffering heavy degradation, loss and potential collapse due to anthropogenic activities. The IUCN Red List of Ecosystems is a transparent and consistent framework for assessing ecosystems' risk of collapse and is increasingly used to inform legislation and ecosystem management globally.
Satellite data have become increasingly common in environmental monitoring due to their extensive spatial and temporal coverage. Here, recent advances in analyses using satellite‐derived data were implemented to reassess the conservation status of the ‘Rakhine mangrove forest on mud’, an important intertidal ecosystem in Myanmar, extending a previous national Red List assessment that assessed the ecosystem as Critically Endangered.
By incorporating additional data sources and analyses, the extended assessment produced more robust results and reduced the uncertainty in the previous assessment. Overall, the ecosystem was assessed as Critically Endangered (range: Vulnerable to Critically Endangered) as a result of historical mangrove extent loss. Recent losses and biotic disruptions were also observed, which would have led to the ecosystem being assessed as Vulnerable.
While the final outcome of the Red List assessment remained at Critically Endangered due to the historical state of the mangroves pre‐dating the temporal coverage from satellite data, the uncertainty of the ecosystem's status was reduced, and the reassessment highlighted the recent areal changes and mangrove degradation that has occurred.
The importance of conducting reassessments when new data become available is discussed, and a template for future mangrove Red List assessments that use satellite data as their primary source of information to improve the robustness of their results is presented.
Robust tracking control for nonlinear fractional order delayed systems: Modified repetitive control approach
Authors: Mahmoudabadi Parvin , Tavakoli‐Kakhki Mahsan 
Published: December 2023

AbstractThis study focuses on the problem of perturbation suppression and tracking control of nonlinear fractional order systems with time‐varying delay. To simplify the control process for such systems, the Takagi–Sugeno fuzzy model is used to describe the nonlinear fractional order delayed systems. Additionally, a modified repetitive controller is applied to develop an output feedback technique for the proposed systems. To ensure system stability, the study establishes new delay‐dependent stabilization conditions using a novel Lyapunov–Krasovskii functional (LKF). These stability conditions are expressed in formation of linear matrix inequalities (LMIs) by adopting a frequency‐distributed model transformation and some slack matrices. The proposed method demonstrates that the system output can track the desired input with ignorable error, while effectively rejecting disturbances. Finally, the efficacy of the proposed method is evaluated through simulations of the modified Chua circuit and the hydraulic turbine governing system (HTGS).
The Fluoride Method: Access to Silver(III) NHC Complexes
Authors: Pueyo Juan , Joven‐Sancho Daniel , Martín Antonio , Menjón Babil , Baya Miguel 
Published: December 2023

AbstractWe have synthesized the first silver(III) carbene complexes, (CF3)3Ag(NHC), by direct reaction of the silver(III) fluoride precursor complex [PPh4][(CF3)3AgF] with different imidazolium salts. This novel methodology circumvents the use of free NHC molecules. The silver(III) carbene complexes thus prepared are unprecedented and show remarkable thermal stabilities. They display square‐planar or square‐pyramidal geometry. Following our calculations, the electronic structure of a model representative complex exhibits Inverse Ligand Field (ILF). The compounds reported herein are synthetic analogues of the elusive difluorocarbene and carbonyl species proposed as intermediates in the acidic decomposition of [Ag(CF3)4]−. The synthetic procedure reported is envisaged to enable access to carbene complexes of other late transition‐metals in high oxidation states.
Perspectives and Potential of Liquid Organic Hydrogen Carriers in the German Energy Scenario
Authors: Herzinger Elisabeth , Wolf Moritz 
Published: December 2023

AbstractThe energy transition is a global process and requires new import routes for energy demanding countries like Germany. Countries with great potential for renewable energy production may become key players in the global energy transition. In this contribution, we assess the potential of the liquid organic hydrogen carrier (LOHC) technology. LOHCs enable an energy‐efficient storage and transportation using existing infrastructure for liquid hydrocarbons. Exemplary roles of LOHCs in the German energy landscape are illustrated. Lastly, LOHC demonstration projects in Germany are presented.
Enumeration potential of environmental DNA for Pacific salmon stock assessments
Authors: Su Geoffrey Y. , Allison Michael J. , Beblow Jordan , Koch Kevin , Anderson Jeffrey , M'Gonigle Leithen K. , Cleveland Mark , Helbing Caren C. , Marlatt Vicki L. 
Published: December 2023

AbstractThe field of environmental DNA (eDNA) has advanced over the past decade, with multiple approaches available for a variety of sampling media and species. While using eDNA for the purpose of simply detecting species is becoming a routine process, the utility of eDNA to estimate species abundance is not well understood. Here, we quantify salmon environmental DNA upstream of a fish counting fence along with river velocity, and together, use these values to determine the correlation between the number of salmon passing by the fish fence daily with daily eDNA rates in water before, during, and after the salmon spawning season for four Pacific salmonids (Oncorhynchus gorbuscha, O. kisutch, O. tshawytscha, and O. nerka; pink, coho, chinook, and sockeye, respectively). Throughout the spawning season, approximately 182,000 salmon were counted passing through the fence, of which >98% were pink salmon. Pink salmon exhibited strong correlation between human counts (effect size = 0.65, SE = 0.040) to eDNA rates in the present study and exhibited day‐to‐day variation and a unimodal profile rising and falling with human fish counts. However, the salmon species observed in much lower numbers exhibited a much weaker correlation with eDNA levels higher during the pre‐migratory period than during the migratory period for sockeye, coho, and chinook. Thus, for salmon spawning runs with less than ~1000 adults and daily counts of less than ~100, the juvenile and/or prior seasons eDNA signal appears to be indistinguishable from the adult spawning eDNA signal in our river system. However, for the large pink salmon run, eDNA rates appeared to reflect a local signal of salmon in space and time, essentially tracking these fish within days of passing through the eDNA sampling site.
Elemental composition and evaluation of noncarcinogenic risks of bee pollen from different Turkish areas
Authors: Temizer İlginç Kızılpınar 
Published: December 2023

Abstract
Bee pollen is a complex compound formed by the honey bee through a mixture pollen, nectar, and bee saliva. It contains many elements that have importance for the human biochemical process. However, when the content of minerals in the pollen exceeds the biological limit, it can be toxic to health. This study aimed to assess and identify the presence of 16 essential (potassium [K], phosphorus [P], calcium [Ca], magnesium [Mg], sodium [Na], iron [Fe], silicon [Si], manganese [Mn], zinc [Zn], boron [B], copper [Cu], molybdenum [Mo], nickel [Ni], chromium [Cr], selenium [Se], and cobalt [Co]) and 16 nonessential elements (aluminum [Al], beryllium [Be], barium [Ba], arsenic [As], cadmium [Cd], mercury [Hg], thallium [Tl], lithium [Li], antimony [Sb], vanadium [V], lead [Pb], rubidium [Rb], strontium [Sr], cesium [Cs], titanium [Ti], and uranium [U]) in bee pollen samples from different floral sources in Turkey, while also evaluating the noncarcinogenic risks associated with bee pollen. A melissopalynological investigation was conducted to identify the plant origins of the bee pollen samples. Thereafter, the levels of 32 elements in bee pollen samples were quantified using inductively coupled plasma-mass spectrometry (ICP-MS). Finally, calculations were performed to determine the recommended dietary allowance percentage (RDA%), estimated daily intake (EDI), target hazard quotient (THQ), and hazard index (HI). The bee pollen samples had varying levels of macro, trace, and ultratrace elements, with K, P, Ca, Mg, and Na being the most abundant macro elements and Ti, Ba, Ni, Cr, and V being the least abundant ultratrace elements. The RDA% values for essential elements in bee pollen were found to vary, with Cu, Zn, Fe, and Cr having the highest levels. The results of the THQ and HI calculations demonstrated that consuming bee pollen at recommended rates did not pose a risk to the health of adults or children. Integr Environ Assess Manag 2024;20:1575–1585. © 2023 SETAC
Key Points
Bee pollen contains varying levels of macro, trace, and ultratrace elements. Bee pollen offers a natural source of essential nutrients for human health, including potassium (K), phosphorus (P), magnesium (Mg), calcium (Ca), copper (Cu), iron (Fe), zinc (Zn), chromium (Cr), manganese (Mn), nickel (Ni), selenium (Se), and molybdenum (Mo). Comparing estimated daily intake values for bee pollen elements with the reference dose (RfD) values suggested no health risk for both adults and children. A health risk assessment (target hazard quotient and hazard index) indicates bee pollen consumption is safe.
The landscape of alterations affecting epigenetic regulators in T‐cell acute lymphoblastic leukemia: Roles in leukemogenesis and therapeutic opportunities
Authors: Walia Yashna , de Bock Charles E. , Huang Yizhou 
Published: December 2023

AbstractT‐cell acute lymphoblastic leukemia (T‐ALL) is an aggressive malignancy accounting for 10%–15% of pediatric and 20%–25% of adult ALL cases. Epigenetic irregularities in T‐ALL include alterations in both DNA methylation and the post‐translational modifications on histones which together play a critical role in the initiation and development of T‐ALL. Characterizing the oncogenic mutations that result in these epigenetic changes combined with the reversibility of epigenetic modifications represents an opportunity for the development of epigenetic therapies. Oncogenic mutations and deregulated expression of DNA methyltransferases (DNMTs), Ten‐Eleven Translocation dioxygenases (TETs), Histone acetyltransferases (HATs) and members of Polycomb Repressor Complex 2 (PRC2) have all been identified in T‐ALL. This review focuses on the current understanding of how these mutations lead to epigenetic changes in T‐ALL, their association with disease pathogenesis and the current efforts to exploit these clinically through the development of epigenetic therapies in T‐ALL treatment.
mRNA‐based chimeric antigen receptor T cell therapy: Basic principles, recent advances and future directions
Authors: Xiao Kaiting , Lai Yanming , Yuan Wenxu , Li Shengjie , Liu Xingxing , Xiao Zebin , Xiao Heng 
Published: December 2023

AbstractNon‐viral vector chimeric antigen receptor (CAR)‐T cells have garnered increasing attention due to their ability to efficiently eradicate cancer cells while mitigating undesirable side effects. However, the current methods for engineering chimeric antigen receptor T (CAR‐T) cells employ viral vectors that result in permanent CAR expression and potentially severe negative impacts. As a solution to these challenges, triggering transitory expression of CARs in T cells via messenger RNA (mRNA) has emerged as a promising strategy. Currently, electroporation is a common method used to introduce the mRNA encoding the CAR into the T cells. Moreover, there has been increasing attention on the exploration of innovative mRNA delivery systems, including lipid, polymer‐based nanoparticle, exosomes and peptide transduction domains. Additionally, we also explored the functions of different types of mRNA in mRNA‐based CAR‐T cell therapy. The auxiliary mRNA, exemplified by systems such as megaTAL and nuclease transposon systems, demonstrates its capacity to extend CAR‐T cell viability and survival. This perspective offers the current state of mRNA‐based CAR‐T cell therapy and provides valuable insights into future research avenues.
Two‐ and one‐photon absorption spectra of aqueous thiocyanate anion highlight the role of symmetry in the condensed phase
Authors: Sarangi Ronit , Nanda Kaushik D. , Krylov Anna I. 
Published: December 2023

AbstractWe present the two‐photon absorption (2PA) spectrum of aqueous thiocyanate calculated using high‐level quantum‐chemistry methods. The 2PA spectrum is compared to the one‐photon absorption (1PA) spectrum computed using the same computational protocol. Although the two spectra probe the same set of electronic states, the intensity patterns are different, leading to an apparent red‐shift of the 2PA spectrum relative to the 1PA spectrum. The presented analysis explains the intensity patterns and attributes the differences between the 1PA and 2PA spectra to the native symmetry of isolated SCN, which influences the spectra in the low‐symmetry solvated environment. The native symmetry also manifests itself in variations of the polarization ratio (e.g., parallel vs. perpendicular cross sections) across the spectrum. The presented results highlight the potential of 2PA spectroscopy and high‐level quantum‐chemistry methods in studies of condensed‐phase phenomena.
What explains collective action: The impact of social capital, incentive structures and economic benefits
Authors: Skreli Engjell , Xhoxhi Orjon , Imami Drini , Rama Klodjan 
Published: December 2023

AbstractThis study focuses in testing the power of reciprocity and leadership as collective action incentive structures and cooperation economic benefits in explaining collective action initiation in the context of a post‐communist transition economy. The paper is based on a structured survey targeting Albanian export‐oriented farmers. Different from most previous studies, this paper uses both regression analysis and machine learning procedure which is better suited for analysing non‐linear relationships. The empirical findings are at odds with common sense that non‐cooperation is the dominant strategy, because the presence of tolerant reciprocators and leadership resources provide promising incentive structures for collective action development.