bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks
Authors: Chen* Wenjing , Song* Young Shin , Lee Han Sai , Lin Chien-Wei , Lee Junguee , Kang Yea Eun , Kim Seon-Kyu , Kim Seon-Young , Park Young Joo , Park Jong-In 
Published: October 2023

Abstract

Mortalin (encoded by HSPA9) is a mitochondrial chaperone often overexpressed in cancer through as-yet-unknown mechanisms. By searching different RNA-sequencing datasets, we found that ESRRA is a transcription factor highly correlated with HSPA9 in thyroid cancer, especially in follicular, but not C cell-originated, tumors. Consistent with this correlation, ESRRA depletion decreased mortalin expression only in follicular thyroid tumor cells. Further, ESRRA expression and activity were relatively high in thyroid tumors with oncocytic characteristics, wherein ESRRA and mortalin exhibited relatively high functional overlap. Mechanistically, ESRRA directly regulated HSPA9 transcription through a novel ESRRA-responsive element located upstream of the HSPA9 promoter. Physiologically, ESRRA depletion suppressed thyroid tumor cell survival via caspase-dependent apoptosis, which ectopic mortalin expression substantially abrogated. ESRRA depletion also effectively suppressed tumor growth and mortalin expression in the xenografts of oncocytic or ESRRA-overexpressing human thyroid tumor cells in mice. Notably, our Bioinformatics analyses of patient data revealed two ESRRA target gene clusters that contrast oncocytic-like and anaplastic features of follicular thyroid tumors. These findings suggest that ESRRA is a tumor-specific regulator of mortalin expression, the ESRRA-mortalin axis has higher significance in tumors with oncocytic characteristics, and ESRRA target gene networks can refine molecular classification of thyroid cancer.

*The authors would like to note that Wenjing Chen and Young Shin Song contributed equally to this work.
An electric kickscooter multibody model: equations of motion and linear stability analysis
Authors: Blanco Alfonso García-Agúndez , Vallejo Daniel García , Freire Emilio 
Published: October 2023

Abstract
In this work, a detailed multibody model of an electric kickscooter is presented. The model includes toroidal wheels as well as rear and front suspensions. The equations of motion are derived and linearized along the steady forward motion of the vehicle. The use of an efficient linearization approach, suitable for complex multibody systems with holonomic and nonholonomic constraints, allows for obtaining the reduced linearized equations of motion as a function of the geometric, dynamic, wheels’ and suspensions’ parameters. The proposed electric kickscooter multibody model is validated with the stability results of a previously presented electric kickscooter benchmark. Since the resulting eigenvalues are parameterized in terms of the design parameters, a detailed linear stability analysis of the system is performed. In particular, the influence on stability of the toroidal geometry of the wheels, the elliptic cross section of the toroidal wheels, the rider model, the steering axis inclination angle, the inertia tensor of the front frame, and the rear and front suspensions is analyzed. The model presented, together with the linearized equations of motion obtained in this work, enables a systematic analysis of the stability of these vehicles, which helps at designing new electric kickscooters with improved vehicle safety conditions and oriented to a wider range of potential users.
Evaluation of ELF-MF Exposure Levels for Elementary School Students in Indoor and Outdoor Environments
Authors: S.D.N.A.M. Amila Madhushanka Weerasinghe , Hong Seung-Cheol 
Published: October 2023

Abstract
This research investigation is focused on evaluating the possible health concerns that may arise for elementary school students due to their proximity to transmission and underground lines near their school. The primary goal of this research is to measure extremely low-frequency magnetic field (ELF-MF) levels during school hours and various other times of the day to ensure that these levels are in accordance with established safety standards, thereby safeguarding the well-being of both students and the school community. A total of 32 personal exposure measurements were collected from elementary students in the Gyeonggi-do region. These measurements encompassed a continuous 24-hour period, covering time spent at school, at home, during extracurricular activities, and in daily life. Some students displayed noticeable spikes in ELF-MF values, particularly during non-school hours, with levels reaching as high as 13.96 µT. This study underscores the significance of acknowledging the possible health risks associated with ELF-MF exposure stemming from common household devices. It emphasizes the importance of consistently maintaining and responsibly using microwave ovens and other electronic appliances to mitigate such risks. Furthermore, the research underscores the necessity for proactive measures aimed at minimizing children's exposure to ELF-MF within the school environment.
Longitudinal Cardiac Evaluation of children with Multisystem Inflammatory Syndrome (MIS-C) Following COVID-19 by Conventional and Speckle-Tracking Echocardiography
Authors: Anagnostopoulou Andriana , Dourdouna Maria-Myrto , Loukopoulou Sofia , Mpourazani Evdoxia , Poulakis Marios , Karanasios Evangelos , Michos Athanasios 
Published: October 2023

Abstract
Multisystem inflammatory syndrome in children (MIS-C), is a rare but severe, hyperinflammatory complication of COVID-19, in which cardiovascular abnormalities are frequently detected. In this prospective study, we describe the echocardiographic findings in patients with MIS-C, with the use of Two-Dimensional Echocardiography and Speckle-Tracking Echocardiography (STE) with Left Ventricle (LV) Global Longitudinal Strain (GLS) analysis, in the acute and follow-up phase. In total, 25 MIS-C patients [64% females, mean (± SD) age: 8.53 (± 3.66) years] were included. In the acute phase, median (IQR) Troponin and NT-proBNP and mean heart rate, were 8.07 (14.52) pg/dL, 2875.00 (7713.00) pg/mL, and 102.87 (± 22.96) bpm, respectively. Median LV Ejection Fraction (LVEF) was 66 (8)% and LVEF impairment was detected in 2/25 (8%) patients. On follow-up (interval 9.5 ± 4.6 months), heart rate was significantly lower, with a mean value of 90.00 (± 14.56) bpm (p-value = 0.017). Median LVEF was 66.00 (6.70)% (p-value = 0.345) and all 25 participants had normal LVEF. In 14/25 patients, additional LV-GLS analysis was performed. During the acute phase, mean LV-GLS was − 18.02 (± 4.40)%. LV-GLS was abnormal in 6/14 patients (42.9%) and among them, only one patient had reduced LVEF. On follow-up (range:5.3–18 months), mean LV-GLS was 20.31 (± 1.91)% (p-value = 0.07) and in 1/14 patient (7.1%), the LV-GLS impairment persisted. In conclusion, myocardial functional recovery was observed during the follow-up of most MIS-C patients. However, in the acute and follow-up phase, we detected abnormal LV-GLS values in some patients, in the presence of normal LVEF, indicating that STE-GLS is a valuable tool for identifying subclinical myocardial injury in MIS-C.
Assessment of risk perception by toxic metals in calcareous soil: evaluate environmental and health fate using multimodal statistical approach
Authors: Mondal Gourav , Ghosh Saibal , Banerjee Sonali , Bhattacharyya Pradip 
Published: October 2023

Abstract

Faulty irrigation practices and industrial activities lead to the pollution of heavy metals (HMs) in agricultural soil, resulting in adverse effects on human health. The present study was conducted for the assessment of source identification, probabilistic health hazard assessments, and analysis of dietary risks associated with HM pollution in the calcareous soil of India. The mean concentrations of total and bioavailable forms of heavy metals (Cr, Ni, Cd, Pb, Cu) surpassed the permissible limits in sample areas (zone1 and 2), with zone 1 showing higher contamination levels compared to zone 2. The free ion activity model (FIAM) was employed to detect HMs in contaminated soil and assess their potential transfer to rice grains. Hazard quotient values were notably higher than the safe threshold (FIAM-HQ < 0.5) for Cr (2.87E-01), Ni (1.08E-01), and Pb (1.88E-01), except for Cd (1.49E-02) and Cu (1.27E-03), which remained within safe limits. Risk thermometer indicates high and moderate human health risk for Cr (CrSAMOE= 0.006) and Ni (NiSAMOE= 0.03), respectively. Self-organizing map (SOM) and positive matrix factorization (PMF) identify pollution sources in the calcareous region. Monte Carlo simulation (MCS) unveiled that children were more vulnerable to total carcinogenic risk (TCR) compared to adults through the ingestion pathway. A geostatistical approach was employed to predict the spatial distribution patterns of various heavy metals across the area. This comprehensive evaluation, utilizing appropriate and reasonable methods, serves as a valuable resource for environmental scientists and policymakers aiming to manage and mitigate HM pollution in agricultural soils near residential areas.
Research on Routing Optimization Model of Demand Responsive Connector under Simultaneous Pickup and Delivery Mode
Authors: Li Jin , Zhang Hongping , Liu Huasheng 
Published: October 2023

Abstract
With the continuous progress of urbanization, the phenomenon of urban suburbanization and the separation of work and housing is becoming increasingly obvious. Due to the low passenger flow density in the suburbs and the poor operation effect of conventional public transportation, there is an urgent need to find a rail transit bus operation mode that is suitable for low passenger density areas such as urban suburbs. Demand Responsive Connector (DRC) is a transportation mode that adopts "online booking and offline travel" to meet the needs of passengers. This paper will focus on the DRC route optimization problem under the simultaneous pick-up mode. This paper analyses the DRC path optimization problem under the single transfer point simultaneous pick-up mode, defines the research situation, proposes the modelling idea, considers the balance of the interests of both passengers and enterprises, and establishes the DRC path optimization model under the single transfer point simultaneous pick-up mode with the goal of maximum passenger satisfaction and minimum enterprise operating cost. According to the characteristics of the model, a multichain chromosome genetic algorithm is designed to solve the model.
Rhizobium hidalgonense and Rhizobium redzepovicii as novel faba bean (Vicia faba) microsymbionts in Mexican soils
Authors: Rivera Flor N. , Guevara-Luna Joseph , Yan Jun , Arroyo-Herrera Ivan , Li Yan , Vásquez-Murrieta Maria Soledad , Arellano Danae Rojas , Wang En Tao 
Published: October 2023

Abstract
As a legume crop widely cultured in the world, faba bean (Vicia faba L.) plants form root nodules with diverse Rhizobium species in different regions. But the symbionts associated with this plant in Mexico has not been studied although it has been cultured for more than 500 years in the country. To investigate the diversity and species-symbiovar affiliations of rhizobia associated with faba bean in Mexico, we isolated the rhizobia of this plant grown in Mexico. Based upon the analysis of recA gene phylogeny, two genotypes were distinguished among a total of 35 isolates, and they were identified as Rhizobium hidalgonense and Rhizobium redzepovicii, respectively, by the whole genomic sequence analysis. Both the species harbored identical nod gene cluster and the same phylogenetic positions of nodC and nifH. So, all of them were identified into the symbiovar viciae. R. hidalgonense was only isolated from slightly acid soil and R. redzepvicii was found in acid and neutral soils in this study. The community composition of rhizobia associated with faba bean in Mexico was unique since these two Rhizobium species previously reported as symbionts of common bean. As conclusion, faba bean rhizobia in Mexico formed novel symbiovar, sv. viciae, in species R. hidalgonense and R. redzepovicii. These results added novel evidence about the co-evolution, diversification and biogeographic patterns of rhizobia in association with their host legumes in distinct geographic regions.
Heterogenous Patterns of Brain Atrophy in Schizophrenia Localize to A Common Brain Network
Authors: Makhlouf Ahmed T. , Drew William , Stubbs Jacob L. , Taylor Joseph J. , Liloia Donato , Grafman Jordan , Silbersweig David , Fox Michael D. , Siddiqi Shan H. 
Published: October 2023

Abstract
Understanding the neuroanatomy of schizophrenia remains elusive due to heterogenous findings across neuroimaging studies. Here, we investigated whether patterns of brain atrophy associated with schizophrenia would localize to a common brain network. Using the human connectome as a wiring diagram, we identified a connectivity pattern, a schizophrenia network, uniting heterogenous results from 90 published studies of atrophy in schizophrenia (total n>8,000). This network was specific to schizophrenia, differentiating it from atrophy in high-risk individuals (n=3038), normal aging (n=4,195), neurodegenerative disorders (n=3,707), and other psychiatric conditions (n=3,432). The network was also stable with disease progression and across different clusters of schizophrenia symptoms. Patterns of brain atrophy in schizophrenia were negatively correlated with lesions linked to psychosis-related thought processes in an independent cohort (n=181). Our results propose a unique, stable, and unified schizophrenia network, addressing a significant portion of the heterogeneity observed in prior atrophy studies.
Uric acid as a predictor of the development of non-alcoholic fatty liver disease in patients with arterial hypertension
Authors: Statsenko M. Е. , Streltsova A. M. 
Published: October 2023

Introduction. Currently, increased uric acid (UA) levels are considered an independent risk factor for the development of non-alcoholic fatty liver disease. Oxidative stress, chronic systemic inflammation, and insulin resistance characteristic of non-alcoholic fatty liver disease (NAFLD) may represent possible mechanisms for the association between the development of hyperuricemia and NAFLD.Aim. To clarify the meaning and nature of the relationship between an increase in the level of UA concentration and the development of NAFLD, as well as to evaluate the relationship between uric acid and the risk of cardiovascular complications in patients with hypertension and NAFLD.Materials and methods. A cross-sectional comparative study was conducted, which involved 120 patients aged from 45 to 65 with hypertension of 1–2 degrees, 1–2 stages (with and without NAFLD (FLI > 60). During the examination, a clinical examination was carried out: analysis of anamnesis data, anthropometry. Lipids and uric acid in blood plasma were also analyzed.Results. In the group of comorbid patients, there were significantly more patients with excess of the reference values of UA levels in the blood plasma (OR = 2.25: 95% CI 1.08–4.71). ROC analysis showed that with an uric acid level of 369.5 µmol/l, a high risk of developing NAFLD is predicted. The UA/Cr index in patients with hypertension and NAFLD was statistically significantly higher than in patients in the control group. Increase in the MK/Kr index by 1 USD increases the chances of developing NAFLD by 1.54 times (95% CI: 1.11–2.13). Also, an increase in the concentration of sUA level by 1 µmol/l increases the chances of an increase in the 10-year risk of cardiovascular events to 5.0% or more by 0.6%.Conclusions. With an uric acid level of 369.5 µmol/l, a high risk of developing NAFLD in the study group is predicted. Increase in UA/creatinine index by 1 USD increases the chances of developing NAFLD by 1.54 times. In addition, an increase in the concentration of sUA in the blood plasma by 1 µmol/l increases the chances of an increase in the 10-year risk of cardiovascular events to 5.0% or more by 0.6% in patients with hypertension and NAFLD.
Pharmacokinetics of first semaglutid drug in Russian Federation: results of open-label randomized clinical trial
Authors: Arefeva A. N. , Banko V. V. , Sadovskikh M. O. , Noskov S. M. 
Published: October 2023

Introduction. Diabetes mellitus is a chronic disease that can impact all aspects of metabolism. Incretin mimetics, such as semaglutide, are a promising group of drugs to treat type 2 diabetes mellitus both through the improvement of glycemic control and additional effects on the cardiovascular system and body weight. The development of a generic semaglutide-containing drug is a burning issue which settlement will increase the availability of semaglutide in the Russian FederationAim. To study the comparative pharmacokinetics, bioequivalence, safety and tolerability of a semaglutide containing GP40221 and Ozempic® in healthy volunteers.Materials and methods. This open-label, randomized, single-dose, parallel group study assessed the bioequivalence of a single dose of 0.5 mg of the study drugs in healthy male subjects under fasting conditions. The conclusion about the bioequivalence of the brand name drug versus the generic drug was made using the classical approach based on the assessment of 90% confidence intervals of the ratios of geometric means of the primary pharmacokinetic parameters (AUC0-t, Сmax) for the active substance of the study drugs.Results. The results of the study showed that the 90% CI values of the ratios of geometric means of the primary PK parameters of semaglutide were 85.96–109.01% and 89.14–111.40% for AUC0-t и Cmax, respectively, and are well within acceptable limits 80.00–125.00%. The comparable safety of the study drugs containing semaglutide has been proven.Conclusion. Thus, GP40221 (GEROPHARM LLC, Russia) and Ozempic® (Novo Nordisk A/S, Denmark) can be considered bioequivalent and equally safe based on the results of this clinical study. The results of this study allow us to recommend a drug developer to submit specific data on their study drug GP40221 to the Ministry of Health of the Russian Federation to obtain marketing authorization.
De clínica a museu: tecendo as trajetórias memoriais de um castelo no centro da cidade de Estrela (RS)
Authors: Sehn Paulo Gustavo , Mangan Patrícia Kayser Vargas 
Published: October 2023

A cidade de Estrela, no Rio Grande do Sul, é atualmente a terceira mais populosa do vale do Taquari, com aproximadamente 33 mil habitantes. Estrela tem 147 anos e foi colonizada inicialmente por imigrantes germânicos. Possui 13 bairros e 4 distritos. Neste artigo, contextualizamos o surgimento da cidade de Estrela, desde a chegada dos primeiros imigrantes até os primeiros indícios do nome “Estrela”. Após situarmos geograficamente a cidade, apresentamos o imóvel referência deste trabalho: um castelo no centro da cidade, construído em 1905 pelo médico austríaco, Dr. Gabriel Schlatter e, através de uma linha do tempo, discutimos as suas transformações e as memórias que envolvem o imóvel, bem como sua importância no contexto da cidade, as relações que ele possui com as pessoas não só de Estrela, mas da região e do estado, o impacto da sua presença na paisagem cultural e geográfica da cidade, sua simbologia na formação identitária das pessoas, bem como sua importância sob o viés de patrimônio.
Not all Erosions are Inflammatory: A Rare Case of Erosive Arthritis with
Fibromatosis
Authors: Almeqbaali Aysha Mohammed , Almehaideb Abdullatif Reyadh , Papineni Vijay Ram , Diab Sehriban , Aneja Ritu 
Published: October 2023

Background::
Polyfibromatosis is a rare syndrome characterized by benign fibrous proliferation in different locations. It can be divided into two major categories:
superficial and deep. Palmar fibromatosis (Dupuytren's contracture) in variable combinations with plantar fibromatosis (Ledderhose's disease),
penile fibromatosis (Peyronie's disease), knuckle pads, and keloids are part of the spectrum seen in polyfibromatosis. There is a rare association of
polyfibromatosis with keloids and erosive arthritis. Only four reported cases of polyfibromatosis with erosive arthritis and/or osteolysis have been
described in the literature. In this report, we present one such case and review the existing literature on this rare syndrome. We also highlight the
possibility of underlying genetic disorders in our patient, such as mucopolysaccharidosis with musculoskeletal manifestation, due to certain
dysmorphic features and optic atrophy.

Case Presentation::
The patient was a 23-year-old female with palmar and plantar fibromatosis accompanied by erosive arthritis. In addition, the patient had facial
dysmorphic features, optic atrophy, and nystagmus. Extensive investigations were conducted, and no evidence of inflammatory rheumatic disease
was found. The Patient exhibited features consistent with polyfibromatosis.

Discussion::
A rare association between polyfibromatosis and erosive arthropathy with osteolysis has been demonstrated in literature through four case reports
spanning from 1979 to 2018. The presence of dysmorphic facial features and ocular complications suggests a possible genetic or metabolic
etiology, such as mucopolysaccharidosis.

Conclusion::
This patient presents a diagnostic and therapeutic challenge. It is important to recognise the non-inflammatory etiology in order to avoid
unnecessary treatment with anti-rheumatic drugs.
New Horizons in Diabetic Neuropathies: An Updated Review on their Pathology, Diagnosis, Mechanism, Screening Techniques, Pharmacological, and Future Approaches
Authors: Aziz Namra , Dash Biswajit , Wal Pranay , Kumari Prachi , Joshi Poonam , wal Ankita 
Published: October 2023

Background:One of the largest problems for global public health is diabetes mellitus (DM) and its micro and macrovascular consequences. Although prevention, diagnosis, and treatment have generally improved, its incidence is predicted to keep rising over the coming years. Due to the intricacy of the molecular mechanisms, which include inflammation, oxidative stress, and angiogenesis, among others, discovering treatments to stop or slow the course of diabetic complications is still a current unmet need.Methods:The pathogenesis and development of diabetic neuropathies may be explained by a wide variety of molecular pathways, hexosamine pathways, such as MAPK pathway, PARP pathway, oxidative stress pathway polyol (sorbitol) pathway, cyclooxygenase pathway, and lipoxygenase pathway. Although diabetic neuropathies can be treated symptomatically, there are limited options for treating the underlying cause.Result:Various pathways and screening models involved in diabetic neuropathies are discussed, along with their possible outcomes. Moreover, both medicinal and non-medical approaches to therapy are also explored.Conclusion:This study highlights the probable involvement of several processes and pathways in the establishment of diabetic neuropathies and presents in-depth knowledge of new therapeutic approaches intended to stop, delay, or reverse different types of diabetic complications.