bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct administration of human leucocyte antigen (dHLA) molecules into tumour sites: proposal for a new immunotherapy for cancer
Authors: Georgopoulos Apostolos P. , James Lisa M. 
Published: October 2023

AbstractNatural elimination of cancer cells is mediated by human leucocyte antigen (HLA) Class I and II molecules [1] that bind to tumour protein fragments, move to the tumour cell surface and engage CD8+ lymphocytes for killing the tumour cell (HLA Class I) and CD4+ lymphocytes for antibody production against the tumour cell (HLA Class II). HLA Class I molecules are present in all nucleated cells, whereas Class II molecules are present only in antigen presenting cells, such as macrophages. These defence mechanisms are suppressed by tumour cells; this tumour-induced immunosuppression is partly reversed by immune checkpoint inhibitors (ICI), thus allowing the HLA-based tumour elimination to be active again; indeed, the success of ICI therapy partly depends on the HLA makeup of the recipient [2, 3]. Here, we propose a novel cancer immunotherapy consisting of administering the mRNA blueprints for the synthesis of specific HLA Class I molecules with high binding affinity and high immunogenicity to a tumour’s neoantigens. This should maximise the effectiveness of HLA-mediated tumour elimination.
Learning to Read Strengthens Functional Connectivity Between the Ventral Occipitotemporal Cortex and the Superior Temporal Gyrus During an Auditory Phonological Awareness Task
Authors: Wang Jin , Joanisse Marc F. , Booth James R. 
Published: October 2023

Purpose:It is often assumed that phonological awareness only reflects children's phonological skill. However, orthographic representations have been found to be automatically involved during phonological awareness tasks, which we refer to as automatic orthographic activation. Although previous longitudinal neural studies have addressed how phonological processing during phonological awareness tasks is bidirectionally related to reading skill in developing children, we do not know how automatic orthographic activation plays a role in reading skill.Method:To address this gap, we measured 40 children's reading skill and brain activity during an auditory phonological task at two time points using functional magnetic resonance imaging. Children were 5.5 to 6.5 years old at the first time point and were followed up approximately 1.5 years later when they were 7 to 8 years old.Results:We found that earlier reading skill predicted children's later functional connectivity during onset processing between the left superior temporal gyrus, a phonological region, and the left posterior ventral occipitotemporal cortex, an orthographic region representing letters.Conclusion:This finding, together with previous studies, suggests that learning to read influences phonological awareness not only by refining phonological representations but also via strengthening the automatic mapping between phonemes and letters during spoken language processing.
Chromosome analysis and the occurrence of B chromosomes in fish parasite Acanthocephalus anguillae (Palaeacanthocephala: Echinorhynchida)
Authors: Orosová Martina , Marková Anna , Zrzavá Magda , Marec František , Oros Mikuláš 
Published: October 2023

The cytogenetics of Acanthocephala is a neglected area in the study of this group of endoparasites. Chromosome number and/or karyotypes are known for only 12 of the 1,270 described species, and molecular cytogenetic data are limited to rDNA mapping in two species. The standard karyological technique and mapping of 18S rRNA and H3 histone genes on the chromosomes of Acanthocephalus anguillae individuals from three populations, one of which originated from the unfavorable environmental conditions of the Zemplínska Šírava reservoir in eastern Slovakia, were applied for the first time. All specimens had 2n = 7/8 (male/female); n = 1m + 1m-sm + 1a + 1a (X). Fluorescence in situ hybridization (FISH) revealed three loci of 18S rDNA on two autosomes and dispersion of H3 histone genes on all autosomes and the X chromosome. In addition to the standard A chromosome set, 34% of specimens from Zemplínska Šírava possessed a small acrocentric B chromosome, which was always found to be univalent, with no pairing observed between the B chromosome and the A complement. The B chromosome had a small amount of heterochromatin in the centromeric and telomeric regions of the chromosomal arms and showed two clusters of H3 genes. It is well known that an environment permanently polluted with chemicals leads to an increased incidence of chromosomal rearrangements. As a possible scenario for the B chromosome origin, we propose chromosomal breaks due to the mutagenic effect of pollutants in the aquatic environment. The results are discussed in comparison with previous chromosome data from Echinorhynchida species.
The Dilemmas of Universal Value and the Possible Solutions
Authors: Wan Jiayi 
Published: October 2023

The concept “universal value”, as one of the most fundamental concepts in Western political discourses, occupies an important place in present international politics. These concepts originated from specific historical contexts and can only be applied to these specific historical contexts. These concepts also play a role in the formation of the modern nation state. However, it should be noted that the origins of these concepts are one-sided and derived from some territorial religious thoughts or the cultural movements of certain regions. With the evolution of the international situation, the core concepts are distorted and fixed, carrying intense political purposes. The transformation of ethnic spirits, the increasingly intense international relationships, and the exchanges of world cultures, all of these factors get in the way of the development of these concepts. Present universal values can not satisfy the needs of international society and even bring conflicts and wars to international society in some extreme cases. All of these phenomena raise considerable concerns about the degree of stability in the international relationship structure and the benign development of globalization. Developing universal values is a challenging task, but it is also likely to be the key to unlocking a whole new international situation.
This article will begin with the analysis of the origin of universal value, its development process, and its practical application, following with further research on the actual cases to investigate which dilemma the universal values are stuck in and the concrete reasons behind it. From there it is expected to find the solutions or paths to these problems. The definition of universal value needs to be further clarified, and the content of universal value needs to be carefully considered and set. It is also important to apply all of these discussions to political governance properly. At the same time, it should be mentioned that exploring the concept of universal value should not only pay attention to its own values, but also to the way it is manifested in global orders. Only in this way can the stability of the international relationships be strengthened through the “universal value”, which will eventually create good conditions for the realization of the overall development of humankind.
Evaluation of Verbal Working Memory and Phonemic Analysis Skills in Adolescents with Cochlear Implant*
Authors: Gökay Nuriye Yildirim , Atalik Güzide , Trank Şadiye Bacik , Tutar Hakan , Karamert Recep , Gündüz Bülent 
Published: October 2023

Abstract
Introduction Adolescents with cochlear implants may have difficulty developing language and memory abilities.
Objective The primary objectives of this study are (1) to evaluate the language skills and verbal working memory performance of early and late diagnosed-intervened cochlear implanted adolescents and (2) to investigate the relationship between the verbal working memory and phonemic analysis skills in adolescents with cochlear implant.
Methods This study included 72 participants with cochlear implant aged between 10 and 18 years. The participants were divided into two groups; those who had first hearing aid at the age of 6 months at the latest and had a first cochlear implant in at least one ear at the latest at 24 months were included in the early group, all the others were in the late group. The phonemic analysis test, a subtest of the test of language development: Primary, 4th edition (TOLD: P-4) – Turkish version, was used to assess language-based abilities, and the meaningless word repetition (MWR) test was utilized to assess verbal working memory.
Results The adolescents with cochlear implants who received early diagnosis and intervention performed statistically significantly better in phonemic analysis scores and verbal working memory tests (p < 0.001). A statistically significant relationship was found between phonemic analysis and verbal working memory skills (Pearson, r = 0.567 and r = 0.659, p < 0.001).
Conclusions Rehabilitation of phonological skills can contribute to the development of verbal working memory in adolescents with cochlear implants. There is a need for further studies on this issue with more detailed tests.
Outcomes of Endoscopic Biliary Drainage in Postsurgical Anatomy Using Endoscopic Ultrasound and Enteroscopy: A Comparative Study
Authors: Jamwal Kapil Dev , Sharma Atul , Padhan Rajesh Kumar , Sharma Manoj Kumar 
Published: October 2023

AbstractObjectives Biliary obstruction is a common problem encountered in postsurgical anatomy, which may lead to serious complications if not treated promptly. Endoscopic drainage is a minimally invasive and effective treatment option for such patients. However, the optimal route of endoscopic drainage, either SBE-ERCP (single-balloon enteroscopy with endoscopic retrograde cholangiopancreatography) or EUS-BD (endoscopic ultrasound-guided bile duct drainage), remains controversial. In this study, we aim to evaluate the feasibility and outcomes of endoscopic drainage using these two techniques in postsurgical biliary obstruction over a period of 7 years.Materials and Methods We conducted a retrospective study of patients who underwent endoscopic drainage for postsurgical biliary obstruction using SBE-ERCP or EUS-BD techniques between 2015 and 2022. The demographic details, clinical presentation, procedure duration, number of sessions required, technical success, complications, and change of procedure from SBE-ERCP to EUS-BD or vice versa were recorded.Results Seventy-five patients, predominantly females with a mean age of 48 years, underwent endoscopic drainage. Forty-eight patients underwent SBE drainage and 27 patients underwent EUS-HG (EUS-guided hepaticogastrostomy). The mean duration of procedure (44 vs. 77 minutes), number of complications (4 vs. 5), technical success rate (93.5 vs. 85%), change of procedure (0 vs. 3), and number of sessions (1.1 vs. 1.8) were significantly less in the EUS-HG as compared to SBE-ERCP.Conclusions Endoscopic biliary drainage is feasible, safe, and effective in postsurgical biliary anatomy but requires high technical expertise. The study proposes an algorithm that can be applied in such group of patients to determine the route for choosing the drainage procedure. This requires further validation with a large prospective cohort.
Beyond cannibalism
Authors: Borowski Gabriel 
Published: October 2023

Abstract
Commonly associated with the concept of cultural cannibalism, the artistic and critical legacy of Haroldo de
Campos (1929–2003) has constituted a significant metaphor in translation studies. Despite growing interest that this concept has
received in the European and North American discourse of the discipline, the idea of anthropophagy spreads unchecked, circulating
freely and contributing to a vast array of analytical approaches. Given a noticeable lack of in-depth insights into the nature of
de Campos’ theory, this process has resulted in a gradual loss of its original specificity. This article aims to provide an
analysis of instances of the use of the cannibalistic metaphor in the English discourse of translation studies, to help understand
the refractions detectable in the reception of de Campos’ concepts.
Enhancement of properties of a cell-laden GelMA hydrogel-based bioink via calcium phosphate phase transition
Authors: Kim Jueun , Raja Naren , Choi Yeong-Jin , Gal Chang-Woo , Sung Aram , Park Honghyun , Yun Hui-suk 
Published: October 2023

Abstract
To improve the properties of the hydrogel-based bioinks, a calcium phosphate phase transition was applied, and the products were examined. We successfully enhanced the mechanical properties of the hydrogels by adding small amounts (< 0.5 wt%) of alpha-tricalcium phosphate (α-TCP) to photo-crosslinkable gelatin methacrylate (GelMA). As a result of the hydrolyzing calcium phosphate phase transition involving α-TCP, which proceeded for 36 h in the cell culture medium, calcium-deficient hydroxyapatite was produced. Approximately 18 times the compressive modulus was achieved for GelMA with 0.5 wt% α-TCP (20.96 kPa) compared with pure GelMA (1.18 kPa). Although cell proliferation decreased during the early stages of cultivation, both osteogenic differentiation and mineralization activities increased dramatically when the calcium phosphate phase transition was performed with 0.25 wt% α-TCP. The addition of α-TCP improved the printability and fidelity of GelMA, as well as the structural stability and compressive modulus (approximately six times higher) after three weeks of culturing. Therefore, we anticipate that the application of calcium phosphate phase transition to hydrogels may have the potential for hard tissue regeneration.
Printable, adhesive, and self-healing dry epidermal electrodes based on PEDOT:PSS and polyurethane diol
Authors: Kateb Pierre , Fan Jiaxin , Kim Jinsil , Zhou Xin , Lodygensky Gregory A , Cicoira Fabio 
Published: October 2023

Abstract
Printable, self-healing, stretchable, and conductive materials have tremendous potential for the fabrication of advanced electronic devices. Poly(3,4-ethylenedioxithiopene) doped with polystyrene sulfonate (PEDOT:PSS) has been the focus of extensive research due to its tunable electrical and mechanical properties. Owing to its solution-processability and self-healing ability, PEDOT:PSS is an excellent candidate for developing printable inks. In this study, we developed printable, stretchable, dry, lightly adhesive, and self-healing materials for biomedical applications. Polyurethane diol (PUD), polyethylene glycol, and sorbitol were investigated as additives for PEDOT:PSS. In this study, we identified an optimal printable mixture obtained by adding PUD to PEDOT:PSS, which improved both the mechanical and electrical properties. PUD/PEDOT:PSS free-standing films with optimized composition showed a conductivity of approximately 30 S cm−1, stretchability of 30%, and Young’s modulus of 15 MPa. A low resistance change (<20%) was achieved when the strain was increased to 30%. Excellent electrical stability under cyclic mechanical strain, biocompatibility, and 100% electrical self-healing were also observed. The potential biomedical applications of this mixture were demonstrated by fabricating a printed epidermal electrode on a stretchable silicone substrate. The PUD/PEDOT:PSS electrodes displayed a skin-electrode impedance similar to commercially available ones, and successfully captured physiological signals. This study contributes to the development of improved customization and enhanced mechanical durability of soft electronic materials.
Performance analysis of aluminium wound double fed induction generator for cost-efficient wind energy conversion systems
Authors: Tezcan Mehmet Murat , Ayaz Murat 
Published: October 2023

Abstract
Currently, both limited fossil fuel resources and environmental factors have increased the use of renewable energy sources. Renewable energy resources, such as wind energy systems, are gaining popularity, resulting in increased competition among manufacturers. This study aims to achieve a cost-efficient wind energy conversion system by designing and analysing the performance of a 250 kVA aluminium wound double-fed induction generator (DFIG). The advantages and disadvantages of aluminium windings are compared with those of copper windings, and three DFIG models are created: Model-1 with a copper winding set, Model-2 with the same geometry as Model-1 but designed with an aluminium winding set, and Model-3 with an aluminium winding set and slightly different stator and rotor diameters. The three DFIG models were analysed using finite element analysis (FEA) in ANSYS Maxwell, and the simulation results were obtained. According to the FEA results, Model-1 with copper windings had a higher efficiency than Model-2 with aluminium windings, but Model-2 had better cost and weight performance than Model-1. Model-3 and Model-1 had similar efficiencies, but Model-3 had a slightly greater torque ripple compared to Model-1 because of a slightly different stator and rotor diameter. Although the total machine weight of the aluminium-wound DFIGs was slightly increased, the total manufacturing costs were less than those of the copper-wound DFIGs at the same efficiency levels.
fastlin: an ultra-fast program for Mycobacterium tuberculosis complex lineage typing
Authors: Derelle Romain , Lees John , Phelan Jody , Lalvani Ajit , Arinaminpathy Nimalan , Chindelevitch Leonid 
Published: October 2023

Abstract

Summary
Fastlin is a bioinformatics tool designed for rapid Mycobacterium tuberculosis complex (MTBC) lineage typing. It utilizes an ultra-fast alignment-free approach to detect previously identified barcode single nucleotide polymorphisms associated with specific MTBC lineages. In a comprehensive benchmarking against existing tools, fastlin demonstrated high accuracy and significantly faster running times.

Availability and implementation
fastlin is freely available at https://github.com/rderelle/fastlin and can easily be installed using Conda.
French Spectral Music and Improvisation
Authors: Lehman Stephen 
Published: October 2023

Abstract
This chapter provides an account of the overlapping histories of French spectral music and Afrological forms of improvisation. A brief overview of the major concerns and preoccupations of both musics is presented, with particular attention paid to the concept of liminality. The author also presents a brief overview of the ways in which his own involvement with French spectral music, jazz, and other forms of Afrological improvisation has informed his current work as a composer. In the process of working towards a more comprehensive understanding of these musical practices the author has been able to begin constructing a rich conceptual framework for his work as a composer/performer. In particular, by focusing on perceptual thresholds as they relate to the harmonic, rhythmic, formal, and improvisational aspects of the author’s music, the author has sought to reinforce some of the important correspondences between the distinct musical traditions informing his work.
Electroacoustics, Optics, and Microtonal Aesthetics in the Music of Georg Friedrich Haas
Authors: Bauer Amy , Morrison Landon 
Published: October 2023

Abstract
The music of Austrian composer Georg Friedrich Haas (b. 1953) is often aligned with the spectralist school of composition, although the composer resists descriptions of his approach that characterize it in terms of any one technical attribute, choosing instead to construct a heterogeneous microtonal aesthetic that cuts across conventional boundaries of genre and style.
Haas’s prodigious and varied output since the eighties treats instrumental sound-color and texture as central elements of musical discourse. The expressive force of pitch and timbral effects in his music has long been bound to a theatrical play with light and shadow, extended in more recent works through a use of electroacoustic technologies to implement tape-delay and additive synthesis models during live performance. The authors attend here to both of these neglected aspects of Haas’s oeuvre through a detailed analysis of excerpts from three mixed works—String Quartet no. 4 (2003), Ein Schattenspiel (2004) for solo piano, and the large ensemble piece …und… (2008–9), and through an analytical treatment of light as a metaphoric and literal aspect of composition in the large-scale orchestral pieces in vain (2000) and Hyperion (2006). These analyses are set against historical and theoretical background (with focus on the theoretical work of Wyschnegradsky) for the composer’s eclectic microtonal aesthetics, a consideration of the enjoinment of pansonic and panoptical spaces, and a reflection on the “microtonal ethics” of Haas’s approach and his recent venture into cultural politics in the work I can’t breathe for solo trumpet in memoriam Eric Garner (2015).
Spectralisms in the Music of Rozalie Hirs and Their Points of Departure in Research and Innovation
Authors: Hirs Rozalie 
Published: October 2023

Abstract
The term spectral music is often understood to refer strictly to use of spectral analysis as the basis for additive instrumental synthesis. This definition is limiting, however, and overlooks the aesthetic impulse at the heart of this practice, namely the quest for new musical materials grounded in empirical research into acoustic and psychoacoustic phenomena. This chapter attempts to expand the definition of spectral compositional practice by proposing a variety of compositional techniques that share the same aesthetic impulse, with applied examples drawn from the authors’ own catalogue: Sacro monte (1997), Book of mirrors (2001), In LA (2003), article 4 (2004), Pulsars (2007), Roseherte (2008), and Venus (2010), among others.
Music History and Historiography in the Chinese Context
Authors: Yang Hon-Lun Helan 
Published: October 2023

Abstract
Chinese music has a long history, and the sonic features of current musical practices are continuously changing as they are passed from person to person through oral transmission; this is music that represents living traditions. In China—just as elsewhere, undoubtedly—ideologies, histories, and music have been intertwined, and geopolitics have shaped and will continue to shape historical narratives. This chapter advocates the safeguarding of different forms of memory-keeping in music and challenges biases produced in written histories, as they tend to reflect the narratives of the victor, the powerful, and the dogmatic—those who have access to the privilege of discourse.
The Amateur and the Professional in Wuhan’s Park Pop
Authors: Horlor Samuel 
Published: October 2023

Abstract
Singers who present versions of Chinese pop classics at daily shows in the parks of Wuhan make good livings from cash tips offered by supporters in the audience. While this may be reason to think of them as “professional” musicians, they also derive various benefits in their relationships with patrons from insisting on “amateur” status. This chapter considers complexities behind the ideals of the amateur and the professional, revealed not only in the individual economic and ideological circumstances of musicians but also in the constitution of these park performances as wider musical occasions. The shows see a melding of amateur and professional qualities in their organizational ethos and underlying modes of communication and creativity, their spatial and orientational setups, and their integration into a system of overlapping publics. Highlighting this melding serves to challenge certain scholarship on Chinese music inclined to idealize one or other notion.