bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energetics of a Solar Flare and a Coronal Mass Ejection Generated by a Hot Channel Eruption
Authors: Zhang Qingmin , Teng Weilin , Li Dong , Dai Jun , Zhang Yanjie 
Published: November 2023

Abstract
Hot channels (HCs) are prevalent in the solar corona and play a critical role in driving flares and coronal mass ejections (CMEs). In this paper, we estimate the energy content of an X1.4 eruptive flare with a fast CME generated by an HC eruption on 2011 September 22. Originating from NOAA Active Region 11302, the HC is the most dramatic feature in 131 and 94 Å images observed by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO). The flare is simultaneously observed by SDO/AIA, the Reuven Ramaty High-energy Solar Spectroscopic Imager, and the Extreme-ultraviolet Imager on board the “behind” Solar Terrestrial Relations Observatory (STEREO). The CME is simultaneously detected by the white-light coronagraphs of the Large Angle Spectroscopic Coronagraph on board the Solar and Heliospheric Observatory and the COR1 coronagraph on board the behind STEREO. Using multiwavelength and multiview observations of the eruption, various energy components of the HC, flare, and CME are calculated. The thermal and kinetic energies of the HC are (1.77 ± 0.61) × 1030 erg and (2.90 ± 0.79) × 1030 erg, respectively. The peak thermal energy of the flare and total radiative loss of the soft X-ray–emitting plasma are (1.63 ± 0.04) × 1031 erg and (1.03–1.31) × 1031 erg, respectively. The ratio between the thermal energies of the HC and flare is 0.11 ± 0.03, suggesting that the thermal energy of the HC is not negligible. The kinetic and potential energies of the CME are (3.43 ± 0.94) × 1031 erg and (2.66 ± 0.49) × 1030 erg, yielding a total energy of (3.69 ± 0.98) × 1031 erg for the CME. Continuous heating of the HC is required to balance the rapid cooling by heat conduction, which probably originates from intermittent magnetic reconnection at the flare current sheet. Our investigation may provide insight into the buildup, release, and conversion of energies in large-scale solar eruptions.
Simon, garçon mutique, conteur de son histoire. Récit croisé de soins institutionnels
Authors: Cruveiller Virginie , Chambon Louise , Valenzuela Valeria , Bastos Laurence , Rajak Jelena 
Published: November 2023

Les troubles de certains enfants autistes entravent l’accès aux mots et à la possibilité de mettre en récit leur vécu. Comment peuvent-ils se penser, se raconter, se construire comme sujet, et partager leur monde interne ? Le cas clinique exposé dans cet article est un récit polyphonique dans lequel des soignants (pédopsychiatres, psychologue et art-thérapeutes) témoignent de la façon dont Simon, jeune garçon autiste mutique, utilise les espaces de soins qui lui sont proposés afin de donner forme et partager son histoire traumatique sous des formes non verbales. En tissant les bribes narratives éparses, l’équipe effectue un travail de liaison et de mise en sens, et participe ainsi à la coconstruction du récit de Simon.
« 8 Murders Cache-cache ». Récit horrifique et adolescence
Authors: Garot Matthieu 
Published: November 2023

Cet article propose d’explorer l’importance des histoires et s’ouvre sur ce que le philosophe allemand Wilhelm Schapp a appelé notre « empêtrement dans les histoires » : cette nécessité humaine que de raconter et de se raconter ; de s’inventer. À partir de là, l’auteur décrit comment, avec une jeune adolescente placée en Maison d’enfants, la création d’une histoire, à deux mains, aura participé à une mise en récit de soi, au dessein d’un soi au cœur de la crise. La forme horrifique devient alors le support privilégié de cette histoire aux enjeux multiples : entre irruption des éprouvés pubertaires et « jeu de bébé » qui aurait dégénéré.
Didaskaleinophobia: Fear of Going to School
Authors: Raturi Manish , Raturi Shalini Lal 
Published: November 2023

Abstract
School phobias can be challenging for parents to deal with. Further, up to 5% of children experience fears about going to school. Herein, the Indian parents of a 5-year-old girl child get perturbed by her anxiety and persistent refusals about going to the newly joined school. Consequently, the parents have penned down their child’s psychology and varied emotions regarding the unfamiliar environments she faced in the configuration of a poem.
Cold Agglutinin Disease: Challenges in the Serological Workup and Management
Authors: Sharma Nimisha , Rajput Saroj , Agarwal Charu , Chatterjee Tathagata 
Published: November 2023

Abstract
Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia associated with autoantibodies that react mainly in the cold. CAD can interfere with immunohematology tests. We report two cases of CAD presented initially as blood grouping discrepancy leading us to further workup. Case I was a 61-year-old female with symptoms of weakness, bone pain, and difficulty breathing with laboratory findings of high cold agglutinin titers of 1:1024. Bone marrow aspirate revealed a mixture of >30% plasma cell and plasma blast. Bone marrow biopsy revealed an interstitial, focal, and nodular pattern of involvement by plasma cells, leading to the diagnosis of plasma cell dyscrasias. Case II analyzed was benign CAD with cold agglutinin titers of 1:64, with no other abnormality. Both patients were managed successfully. We report serological and clinical findings of two CAD cases with similar serological findings but different clinical outcomes.
Prevalence of pulmonary tuberculosis in post-coronavirus disease patients
Authors: Nain Sandeep , Gupta Rajesh , Gupta Anupama , Verma Sheetal , Gupta Raghav , Parmar Aparna 
Published: November 2023

Abstract

Context
Post-coronavirus disease 2019 (COVID-19) disease patients are immunocompromised, especially those who have a history of hospitalization during the COVID time and steroid use during hospitalization. Such patients are very susceptible to opportunistic infections and must be assessed proactively.

Patients and methods
This was a cross-sectional study on 125 post-COVID-19-positive patients 28 days after being COVID negative confirmed by an RT-PCR test. Sputum/bronchoalveolar lavage samples were taken for analysis.

Statistical analysis used
SPSS, version 20.0 was used for the analysis. A P value less than 0.05 was considered statistically significant.

Results
Out of 119 sputum samples assessed, 15 were AFB positive, and Mycobacterium tuberculosis (MTB) was detected in 16 patients by the GeneXpert assay, out of which 15 were sensitive to rifampicin and one was resistant. Bronchoalveolar lavage was performed in nine patients where two were found AFB-positive, and MTB was detected in two patients by the GeneXpert, out of which one was rifampicin sensitive and one was rifampicin resistant.

Conclusions
A significant portion of the world population has latent tuberculosis (TB) infection, and the COVID-19 disease may have led to an increase in the incidence of active TB. A proactive approach is needed for the diagnosis of TB and to control the spread of TB.
Study of COVID-19 confirmed cases in isolation hospital in (Hurghada General Hospital)
Authors: Younis Samar B , Ahmed Mona M , Daif Marwa S 
Published: November 2023

Abstract

Background and purpose
The WHO declared the coronavirus disease 2019 (COVID-19) outbreak a global public health emergency on January 30, 2020, and the word ‘pandemic’ was first used to describe the disease’s global spread in March of that year. Chronic lung disease (19.2% was the most common co-occurring condition with COVID-19), at 20.8%, followed by chronic kidney disease (20.8%), and then cardiovascular disease (60.9%). This research aimed to assess the prognosis of COVID-19-confirmed cases receiving isolation care at Hurghada General Hospital.

Study design
An observational study that was retrospective and cross-sectional.

Setting
Isolation department in Hurghada General Hospital.

Patients
We included 122 patients with COVID-19 infection, and classified them into two independent groups: the improvement group (93 patients), and the morbidity (complication) and mortality group (29 patients).

Methods
Clinical data (COVID-19 symptoms and vital signs), laboratory data (complete blood count, C-reactive protein, ferritin level in the blood, hepatic and renal functions tests, coagulation profile, and level of D-dimer), radiological data (computed tomography of the chest), and drug and antibiotic data were collected from all patients. The following parameters were assessed in each patient: length of hospital stay, ICU admission, mechanical ventilation, morbidity (complication), mortality, improvement, and discharge.

Results
Patients’ average age in the sample was 55 ± 16.3 years. Regarding patients’ respective sexes, 55.7% of patients were females, while 44.3% were males. Regarding the final outcome data, the average length of hospital stay was 9.2 ± 6.2 days, with 33.6% of patients having ICU admission, 9% were ventilated, morbidity(16.4%) (complication) (4.9% psychological and neurological disorders, 3.3% post-COVID oxygen-dependent therapy, 8.2% renal impairment), and mortality (7.4%), while 76.2% had improved and discharged. Logistic regression results demonstrated that the increase in age, BMI, lactate dehydrogenase, D-dimer, computed tomography chest affection, and COVID-19 severity (according to clinical, laboratory and radiological data); added to the risk of needing to be admitted to a hospital’s ICU on its own (P<0.05, respectively). Decreases in oxygen saturation, urea, and prothrombin time were found to independently increase the likelihood of ICU admission in a logistic regression analysis (P<0.05).

Conclusion
We conclude that age and comorbidities such as diabetes, hypertension, ischemic heart disease, and lung fibrosis are strongly related to adverse outcomes in COVID-19 patients admitted to the Hurghada Isolation Hospital. It was also more likely that those patients would develop acute respiratory distress syndrome or severe pneumonia.
Strict treatment protocol and isolation lead to better outcomes.
Role of right heart catheterization in diagnosis of pulmonary arterial hypertension
Authors: Elmonim Samar M A , Elsharawy Dalia E , Elsheikh Raghda G , Elkholy Mohamed G A 
Published: November 2023

Abstract

Background
Pulmonary hypertension (PH) presumably has an impact on 1% or less of the world’s population. Right Heart Catheterization (RHC) is essential for determining PH problems. RHC determines prognosis and offers helpful information on the degree of hemodynamic impairment. Therefore, this comparative study was carried out to determine the diagnostic role, pitfalls associated, and complications encountered during RHC in suspected cases of PAH and chronic thromboembolic pulmonary hypertension (CTEPH).

Methods
The observational cohort study was conducted on 75 patients with clinical suspicion of PH and CTEPH. All patients were subjected to full history taking, ECG, Echocardiography, and radiological investigations including Chest radiography (CXR), high-resolution computed tomography (HRCT), and computed tomography (CT) pulmonary angiography.

Results
The mean pulmonary artery mean pressure (PAMP) was 46.05 ± 9.631 mmHg, the mean Pulmonary artery dilatation (PAD) was 30.04 ± 1.082 mm the mean ejection fraction (EF%) was 63.87%, the mean right ventricular diameter was 45.83 ± 0.444 mm. The mean pulmonary artery wedge pressure (PAWP) was 10.91 ± 2.303 mmHg, and the mean cardiac output (CO) was 4.00 ± 0.773 L/min mean cardiac index (CI) was 1.94 ± 0.416 L/min/m2. Doppler echocardiographic estimated pulmonary artery systolic pressure (DE-ePASP) and estimated pulmonary, artery, end-diastolic pressure (ePADP) significantly positively correlated with RHC-PASP (P < 0.001) and mean DE-ePAP significantly positively Correlated with mean RHC-PAP (P < 0.001).

Conclusions
RHC is still the only method that can completely and accurately diagnose PAH. however, the combination between right cardiac catheterization and echocardiography provides a more accurate diagnosis of the diseases and their complications.
Intrapleural streptokinase with pigtail catheter drainage versus medical thoracoscopy in complicated parapneumonic effusion
Authors: Abou Ismail Mervat A , Gad Ahmed Y , Elmallawany Hatem A , Moussa Hany H 
Published: November 2023

Abstract

Context
Parapneumonic effusion and empyema are commonly encountered by the pulmonologist. The decision regarding management is still challenging.

Aim
To compare outcomes of intrapleural streptokinase with pigtail catheter drainage versus medical thoracoscopy in complicated parapneumonic effusion.

Methods and material
Forty patients with complicated parapneumonic effusion were randomly allocated to one of two groups. Twenty patients underwent streptokinase intrapleural instillation via pigtail catheter. The other twenty patients underwent medical thoracoscopy.

Results
Intrapleural streptokinase instillation procedure was significantly shorter duration (12.80 ± 3.05 min) than medical thoracoscopy procedure (25.26 ± 4.66 min). However medical thoracoscopy showed a significant less days required to remove the drainage system (5.80 ± 1.70 days) versus intrapleural streptokinase instillation procedure (9.40 ± 3.91 days). Both groups had no significant complications. Lung expansion was achieved in 90% of patients treated with intrapleural streptokinase instillation and in 95% of patients treated with a medical thoracoscopy technique, with no statistically significant difference between the two groups.

Conclusions
Treatment of complicated parapneumonic effusions is undeniably interdisciplinary. Both intrapleural streptokinase with pigtail catheter drainage and medical thoracoscopy are safe and improve outcomes in complicated parapneumonic effusion. Medical thoracoscopy has an advantage of fewer days required for tube withdrawal. Pigtail insertion has an advantage of shorter procedure time compared to medical thoracoscopy
Anesthetic management of a case of pulmonary alveolar proteinosis for whole lung lavage
Authors: Seth Manik , Kachru Nishtha , Kohli Santvana , Balakrishnan Ira , Chauhan Richa , Kumar Virendra 
Published: November 2023

Abstract
Pulmonary Alveolar Proteinosis (PAP) is a rare disease of the lungs characterized by deposition of lipo-proteinaceous material in the alveoli. This leads to reduced lung compliance and V/Q mismatch, causing respiratory failure. Patients with PAP may be posted for Whole Lung Lavage (WLL) under anesthesia, which is a challenging case for anesthetists. Preexisting respiratory failure is complicated by requirement of single lung ventilation with the help of double lumen tube during the procedure. Intraoperative ventilation is difficult and is managed with blood gas and airway pressure monitoring. Some degree of hypoxemia and hypercapnia may have to be tolerated. Large volumes of fluid are instilled into the lung which may cause hypothermia, hypervolemia, and electrolyte disturbances. These patients frequently require elective ventilation and intensive care admission in the postoperative period.
We report the case of a young woman with PAP, posted for unilateral WLL under anesthesia. We wish to highlight the possible challenges posed by this case and how to conduct a safe anesthesia for this patient.
Head-to-Head Comparison of Tapentadol Nasal Spray and Intravenous Tramadol for Managing Postoperative Moderate-to-Severe Pain: An Observational Study
Authors: Shetty Sunil , Kale Sachin , Singh Shikhar , Mandal Shobhan , Sharma Vidur , Shah Varmit , Sabbani Komal , Patil Aloukika Paresh 
Published: November 2023

Background:
Tapentadol is known for its opioid-sparing effect, reducing adverse effects associated with opioids, particularly gastrointestinal issues. However, limitations in the oral formulation warrant exploration of alternatives like tapentadol nasal spray for enhanced efficacy and patient experience.

Aims and Objectives:
This investigator-initiated trial aimed to assess the safety of tapentadol nasal spray (45mg/dose, administered four times daily) compared to intravenous tramadol (50mg twice daily) in patients with post-operative moderate to severe pain over a 3-day period.

Materials and Methods:
A randomized, open-label real-world trial enrolled 600 patients. Pain management efficacy, sleep scores, and patient comfort and convenience were evaluated.

Results:
Tapentadol nasal spray demonstrated superior pain reduction compared to intravenous tramadol. Sleep scores were significantly better with tapentadol nasal spray. The nasal route provided enhanced comfort, convenience, safety, and efficacy, offering rapid pain relief.

Conclusion:
Tapentadol nasal spray presents a favorable option for post-operative pain management, offering improved pain reduction, better sleep outcomes, and enhanced patient comfort. The nasal delivery method proves efficient and patient-friendly, marking a significant advancement in achieving early and sustained pain relief.
Changing Trends in the Clinical Suspicion of Scrub Typhus in Acute Febrile Illness Patients
Authors: Shukla Rajat , Kumar Ajay , Katya Col Amit , Kompella K. K. , Pattanayak Somali , Menon Anand , Sasikanth M. 
Published: November 2023

Abstract

Introduction:
Scrub typhus is an important and widespread cause of acute febrile illness (AFI), which can be diagnosed easily by serological assay.

Methods:
All cases of AFI were sent for Scrub Typhus serology by rapid Enzyme Linked Immuno-Sorbent Assay (ELISA) method. Anyone found positive was admitted for further evaluation.

Results:
In this series 80 % had liver abnormality, 80 % had ARDS, 40 % had renal failure, 40 % had eschar and 80 % of them had MODS. Only 20 % had clinical features of encephalitis with MRI brain haemorrhagic transformation of infarct. All patients responded well to treatment with Doxycycline with hospitalization of around 7-10 days.

Conclusion:
This case series highlights the importance of keeping a high index of clinical suspicion to exclude scrub typhus in all AFI patients.
T-regulatory Cells in Acute Leukemia and their Relation with Induction Outcome
Authors: Gupta Arunima , Somasundaram Venkatesan , Tripathi Preeti , Kular Janmeet , Singh Kanwal Jeet , Bhatia Jasvinder Kaur 
Published: November 2023

Abstract

Background:
The leukemic microenvironment has become an area of interest for researchers in recent times. Nonmalignant T and B lymphocytes form a significant part of leukemic microenvironment and are postulated to have an effect on its progression and behavior. These lymphocytes are constantly interacting with blasts and are actively involved in innate and acquired immune responses against these blasts. We decided to look at the role of T-regulatory lymphocytes in tumor surveillance and treatment outcome.

Aim and Objectives:
The aims and objectives of the study are to evaluate the role of T-regulatory lymphocytes in acute leukemia cases and its correlation with treatment outcome.

Materials and Methods:
We evaluated consecutive 55 acute leukemia cases to investigate the prognostic effect of T-regulatory cells (T-regs) in acute leukemia. The study period was between January 2021 and December 2021. All patients whose complete records were available till the completion of induction were included in the study. The immunophenotype used to characterize and evaluate T-regs was CD4+CD25+ T lymphocytes. For comparison, a total of 10 healthy controls were included in the study. Clinicohematological parameters including fever, lymphadenopathy, hepatosplenomegaly, extramedullary involvement, day 1 total leukocyte count, and blast percentage in peripheral blood and bone marrow were studied and documented to establish any possible correlation with T-regs percentage and treatment outcome. The treatment outcome evaluated in the study was complete remission postfirst induction.

Results:
As compared to those of healthy participants, the frequencies of CD4+CD25+ T-regs in the peripheral blood of acute leukemia patients were significantly increased (1.5% [range: 0.50%–4.3%] vs. 0.58% [range: 0.40%–1.05%], P = 0.0001). Furthermore, the frequencies of CD4+CD25+ T-regs in the peripheral blood of acute leukemia patients who did not achieve remission were significantly increased as compared to those who achieved remission (2.9% [range: 0.20%–4.3%] vs. 1.3% [range: 0.30%–2.9%], P = 0.002). No significant correlation was noted in the T-reg cells and parameters such as fever, lymphadenopathy, hepatosplenomegaly, extramedullary involvement, day 1 total leukocyte count, and blast percentage.

Conclusion:
This study suggests the possibility of using T-regs percentages as a prognostic indicator of acute leukemia and possible role of anti-T-regulatory immunomodulators in improving the outcome of disease.
Educational Game Design for Girls and Boys
Authors: Mozelius Peter , Humble Niklas 
Published: November 2023

INTRODUCTION: Programming is an important skill in the 21st century and it is important to reach and motivate the younger audience. Educational games have proved to motivate students, but research reports about girls not feeling welcome in game environments.
OBJECTIVE: The overall objective of this study is to gather information for the development of a preliminary conceptual model for girl inclusive educational game design.
METHODS: This study was conducted as a requirement-focused Design science study. The focus was set on gathering requirements for a future design and development of educational games on fundamental programming.
RESULTS: A thematic analysis resulted in the main themes of Exploration Without Violence, Collaborative Interaction, Character Diversity, Customisation, Graphics, Game Mechanics, Game Content, and Learning and Motivation
CONCLUSION: The accumulation of results from the literature study and the survey have been merged into a preliminary conceptual model. The conclusion is that a thoughtful consideration of the found factors can support the idea of a Girl Inclusive Educational Game Design.
Tangle equations, the Jones conjecture, slopes of surfaces in tangle complements, andq-deformed rationals
Authors: Sikora Adam S. 
Published: November 2023

AbstractWe study systems of two-tangle equations$$ \begin{align*}\begin{cases} N(X+T_1)=L_1,\\ N(X+T_2)=L_2, \end{cases}\end{align*} $$which play an important role in the analysis of enzyme actions on DNA strands.We show that every system of framed tangle equations has at most one-framed rational solution. Furthermore, we show that the Jones unknot conjecture implies that if a system of tangle equations has a rational solution, then that solution is unique among all two-tangles. This result potentially opens a door to a purely topological disproof of the Jones unknot conjecture.We introduce the notion of the Kauffman bracket ratio$\{T\}_q\in \mathbb Q(q)$of any two-tangleTand we conjecture that for$q=1$it is the slope of meridionally incompressible surfaces in$D^3-T$. We prove that conjecture for algebraicT. We also prove that for rationalT, the brackets$\{T\}_q$coincide with theq-rationals of Morier-Genoud and Ovsienko.Additionally, we relate systems of tangle equations to the cosmetic surgery conjecture and the nugatory crossing conjecture.