bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Uncommon Display of the Sickle Cell Trait Coupled with the Beta-Thalassemia Trait as Hypersplenism
Authors: Patel Divyesh , Desai Vedangi , Doshi Palak , Darda Shubham R. , Lakhani Jitendra D. 
Published: January 2024

Abstract
A structural flaw in the globin gene causes hemoglobinopathies, while a flaw in the globin chain’s synthesis causes thalassemia. One of the most prevalent hemoglobinopathies worldwide is sickle cell disease. Any region of the body can be affected, but the spleen is one of the most often afflicted and the first organs to suffer damage in sickle cell anemia (SCA). Splenomegaly, splenic infarction, hypersplenism, and acute splenic sequestration are the most common manifestations. Usually enlarged in the first 10 years of life, it gradually atrophies and eventually requires an autosplenectomy. It is well established that splenic complications from SCA are linked to higher rates of morbidity and in some cases, even death. This case report discusses a unique presentation of a patient who has hypersplenism together with beta-thalassemia and sickle cell trait. This is a case report of the adult patient admitted in Dhiraj General Hospital, SBKS MIRC, Sumandeep Vidyapeeth, Waghodia, Piparia, Vadodara-391760. The high-performance liquid chromatography (HPLC) technique was used to diagnose thalassemia trait and sickle cell trait. The clinical, ultrasonographic and computed tomography scan methods have been used to identify splenomegaly. The patient had clinical symptoms suggestive of beta-thalassemia and sickle cell trait with hypersplenism. This was supported by his peripheral smear, ultrasonography, contrast-enhanced abdomen–pelvis, HPLC, and bone marrow biopsy. It is imperative that clinicians remain cognizant of this infrequent consequence. Hence, early diagnosis and genetic counseling are of great importance for improving the prognosis of these patients.
Carnosol ameliorates sevoflurane induced cognitive impairment in aged rats by suppressing NLRP3 inflammasome via activation of autophagy
Authors: Zheng Simin , Li Siyuan , Liu Hongtao , Teng Yunpeng , Liu Ying , Xiong Hongfei 
Published: January 2024

Purpose: To investigate the effect of carnosol on the progression of postoperative cognitive dysfunction (POCD) and to elucidate its mechanism of action.
Methods: A cognitive impairment model rat induced by sevoflurane (SEV) was established. Dihydroethidium (DHE) assay was conducted to determine the effect of carnosol on reactive oxygen species (ROS) levels in sevoflurane-induced rats. Adenosine triphosphate (ATP) production and immunoblot assays were used to assess carnosol effect on mitochondrial damage, while water maze experiment was performed to evaluate cognitive dysfunction in the rats. The mechanism of action was investigated using immunoblot assay.
Results: Carnosol suppressed sevoflurane-induced ROS production in the rats, and alleviated sevoflurane-induced mitochondrial damage; it also activated autophagy. Furthermore, carnosol suppressed SEV-induced NLRP3 inflammasome activation by activating autophagy and suppressing SEV-induced cognitive dysfunction via the suppression of NLRP3 inflammasome activation.
Conclusion: Carnosol ameliorates SEV-stimulated cognitive impairment by suppressing NLRP3 inflammasome and thus, can potentially be developed serve as a therapeutic agent for the management of cognitive impairment.
Giải quyết tranh chấp thỏa thuận cổ đông bằng hòa giải thương mại
Authors: Lượng Lê Duy 
Published: January 2024

Hiện nay, nhiều doanh nghiệp còn chưa biết về những lợi ích to lớn khi giải quyết tranh chấp bằng Hòa Giải Thương Mại (HGTM) và pháp luật Việt Nam chưa có quy định về Thỏa Thuận Cổ Đông (TTCĐ). Chính vì vậy, việc phân tích, nghiên cứu để nêu bật các lợi ích khi giải quyết tranh chấp bằng HGTM, làm rõ tính pháp lý của TTCĐ và khi có tranh chấp TTCĐ thì có được đưa ra HGTM để giải quyết hay không là điều cần thiết.
Các kết quả nghiên cứu sẽ được chỉ ra qua phương pháp tra cứu, phân tích, diễn dịch, quy nạp. Kết quả nghiên cứu sẽ giúp giảm thiểu rủi ro cho các cổ đông, hoạt động quản trị của công ty.
When global logistics networks led us to reconsider the role of strategist state. Another look at “France Logistique 2025”
Authors: Camman Christelle , Livolsi Laurent 
Published: January 2024

The positioning of States in global value chains has become a highly important competitive factor. Logistics and transportation constitute therefore an important lever for strategical action by states. In light of these issues, this article intends to report on the national logistics strategy, “France Logistique 2025”, whose roadmap was presented in March 2016. Beyond the deconstruction of its content and process, the objective here is to enrich the reflection about the strategist-state role and the missions in the definition and implementation of a policy, which cuts naturally across activity sectors and territories.
Le positionnement des États au sein des global value chains est devenu un enjeu majeur de compétitivité. La logistique et le transport constituent, dans ce cadre, de véritables leviers d’action stratégique des États. Au regard de ces enjeux, l’article propose de dresser un bilan de la stratégie logistique nationale, France Logistique 2025, dont la feuille de route a été présentée en mars 2016. Au-delà d’en déconstruire le contenu et le processus, l’objectif est ici d’enrichir aussi la réflexion sur le rôle et les missions de l’État-stratège dans la définition et le déploiement d’une politique par nature transversale aux secteurs d’activité et aux territoires.
Mission of Samara State Transport University
Authors: Garanin M. A. , Gnatyuk M. A. , Khorovinnikova E. G. 
Published: January 2024

Samara State Transport University (SamGUPS) is the largest transport university in the Volga Federal District, training specialists for the country’s railway transport and for many other areas of the national economy.The institution was founded in 1973 as the Kuibyshev Institute of Railway Transport Engineers, primarily to meet the need for highly qualified engineering staff of the Kuibyshev Railway, one of the largest railway enterprises of the USSR.In 1991, in connection with the renaming of the city of Kuibyshev and the return of its historical name Samara, the university was renamed Samara Institute of Railway Transport Engineers (SamIIT).Over the past period the higher education institution has consistently raised its academic status — first to the Academy, becoming Samara State Transport Academy, and in 2007 — winning the right to be called Samara State Transport University.The article presents the main goals and objectives of the university and the achieved results of the university development, tells about the interaction of Samara State University of Railway Transport with related branch and engineering universities in our country and abroad, tells about the interaction with transport, construction and infrastructure enterprises in the cities of the region.
Real-world retention rate, effectiveness, and safety of netakimab in the treatment of patients with ankylosing spondylitis: First year results of the LIBRA post-registration safety study
Authors: Erdes Sh. , Mazurov V. I. , Gaydukova I. Z. , Anoshenkova O. N. , Vinogradova I. B. , Grabovetskaya Yu. Yu. , Davidian S. Yu. , Epifanova O. E. , Kiryukhina N. A. , Masneva L. V. , Menshikova I. V. , Mironenko O. N. , Nikulenkova N. E. , Povarova T. V. , Polyatika A. N. , Samigullina R. R. , Sizikov A. E. , Totrov I. N. , Umnova I. F. , Usacheva J. V. , Chudinov A. L. 
Published: January 2024

Background. Netakimab has shown high efficacy in controlled clinical trials in the treatment of patients with ankylosing spondylitis (AS). This article presents results of an observational study of netakimab using in routine clinical practice.Methods. Patients were recruited for the study from August 2020 to December 2021 at 23 centers in the Russian Federation. The study included patients who were prescribed netakimab therapy before enrollment, so clinical and medical history data for the first visit were entered retrospectively, and following visits at weeks 12, 24 and 52 of therapy were collected within the study. Drug survival rate has been calculated according to Kaplan – Meier analysis.Results. The study included 137 patients (93 men and 14 women) with AS. The average age of patients was 42.3 (±11.9) years, 34.3% of patients had previously received therapy with genetically engineered biologic drugs, mainly tumor necrosis factor inhibitors. At the end of the analyzed period (52 weeks of therapy), 90.4% [95% CI: 85.4–95.7] of patients continued treatment with netakimab. The BASDAI and ASDAS-CRP showed statistically significant decreases in scores from baseline at all time points. Netakimab was well tolerated by patients; adverse effects (AEs), related to therapy according to the investigator’s opinion, were reported in 7 (5.1%) patients. 2 patients stopped taking netakimab due to AEs: terminal ileitis and chronic colitis.Conclusions. In real-world clinical practice, netakimab demonstrated high retention rates, a favorable safety profile, and sustained efficacy throughout the first year of therapy.
Preterm Retinopathy of Prematurity and risk factors from a tertiary health care unit: A descriptive study
Authors: Nagajyothi Vura U V , Gare Karunakar , Thummakomma Murali krishna , Amgothu Mohan , Latha Guguloth , Kalyani A , Chandra T Jaya , G Prathap 
Published: January 2024

Abstract

Introduction: Retinopathy Of Prematurity (ROP), is the major preventable blindness in infants. A study was conducted to find the risk factors of ROP in premature infants with gestational age (GA) < 36 weeks.

Methods: It was a descriptive study conducted in Kakatiya Medical College, Hanumakonda. Babies with major congenital, chromosomal anomalies were excluded. One hour before screening, a drop of Tropicamide was instilled for every 10 – 15 minutes for 4 times followed by a drop of Phenylephrine just before examination. ROP screening was carried out by a senior ophthalmologist in NICU. First, the anterior segment was examined. This was followed by sequential examination of all clock hours of the peripheral retina and findings were recorded. Association between variables was analysed by using Chi-Square test. P < 0.05 was considered to be statistically significant.

Results: ROP was detected in 31.4%; statistically there was no significant difference between gender. Apnoea, hyperbilirubinemia, anaemia, respiratory distress were found to be the risk factors for ROP; statistically there was significant difference, respectively.

Conclusion: Preventing prematurity is the best way to reduce ROP. Proper coordination between obstetrician, neonatologist and ophthalmologist can help to reduce the incidence.
Use of the Weekly Calendar Planning Activity to Assess Executive Function in Adolescents With Autism Spectrum Disorder
Authors: Tamm Leanne , Hamik Elizabeth M. , Zoromski Allison K. , Duncan Amie 
Published: January 2024

Abstract
Importance: Youths with autism spectrum disorder (ASD) have challenges with executive function (EF). However, there are few measures to objectively assess EF, such as time management and prioritization. The Weekly Calendar Planning Activity (WCPA) is a promising performance-based EF measure that has rarely been used with youths with ASD.
Objective: To characterize the performance of youths with ASD on the WCPA and the association of WCPA performance with caregiver-rated EF.
Design: Observational and summary data obtained during a baseline evaluation for a research study.
Setting: Middle school.
Participants: Thirty-nine adolescents with ASD and without an intellectual disability.
Method: Youth were administered the WCPA; caregivers completed EF ratings. Descriptive statistics characterized WCPA performance. Correlations between WCPA scores and age, IQ, and EF ratings were computed.
Results: The majority of youth performed poorly on the WCPA and lacked insight into their poor performance. Many struggled to enter appointments. Appointment accuracy was &lt;30%. The most common errors were location errors. Appointment accuracy and planning time were moderately associated with IQ but not with caregiver-rated EF or age.
Conclusions and Relevance: Overall, the WCPA was cognitively demanding for youths with ASD without an intellectual disability. These results have implications for using evidence-based strategies to teach adolescents with ASD how to manage their time and plan and prioritize homework assignments, upcoming tests or quizzes, and extracurricular activities.
Plain-Language Summary: Youths with autism spectrum disorder have significant problems with executive function, particularly organization, prioritization, time management, and planning. There are few objective, performance-based measures of executive function, especially those that can be used with autistic youths. To our knowledge, this study is the first to use the Weekly Calendar Planning Activity (WCPA) with autistic adolescents who do not have an intellectual disability. The WCPA captured their deficits related to executive function and could be a useful tool for assessment and treatment planning.
Roko Molas Poco” Tradisi Membangun Suku Manggarai dalam Upaya Pelestarian Artefak Adat
Authors: Setiadi Ahsan Hidayat , Nahdatunnisa Nahdatunnisa , Syah Andi Al-Mustagfir 
Published: January 2024

Roko Molas Poco merupakan suatu tradisi ritual dalam membangun rumah adat Mbaru Gadang bagi masyarakat manggarai di Nusa Tenggara Timur yang melibatkan kegiatan partisipasi masyarakat secara transformasional sehingga di dalamnya terkandung makna serta nilai yang dapat menjadi asset pengetahuan yang absolut sebagai salah satu asset budaya bangsa serta menjadi bukti kekakayan budaya yang dimiliki oleh negara indonesia. Rumah adat Mbaru Gadang menjadi suatu refleksi dari keniscayaan adat budaya yang diwujudkan dalam bentuk artefak rumah adat bagi masayarakat manggarai. Peneletian ini dilakukan dengan metode deskriptif kualitatif dengan tema naratif berdasarkan studi yang dilakukan berdasarkan kumpulan studi liratur jurnal terkait Mbaru gadang atau rumah adat masyarakat manggarai. Penilitian ini tentunya diharapkan mampu untuk dapat mengungkap eksistensi dari nilai-nilai tradisi masayarakat manggarai dalam proses membangun rumah adat Mbaru gadang serta dapat memberikan tambahan kontribusi pada keilmuan terkait filsafat arsitektur tradisional yang terkandung didalamnya. Kaidah-kidah ataupun cara masyarakat membangun tentunya dapat menjadi refersensi arsitektur budaya dan rujukan pagi praktisi arsitektur dalam pelestarian artefak nasional.
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GloLakes: water storage dynamics for 27 000 lakes globally from 1984 to present derived from satellite altimetry and optical imaging
Authors: Hou Jiawei , Van Dijk Albert I. J. M. , Renzullo Luigi J. , Larraondo Pablo R. 
Published: January 2024

Abstract. Measuring the spatiotemporal dynamics of lake and reservoir water storage is fundamental for assessing the influence of climate variability and anthropogenic activities on water quantity and quality. Previous studies estimated relative water volume changes for lakes where both satellite-derived extent and radar altimetry data are available. This approach is limited to only a few hundred lakes worldwide and cannot estimate absolute (i.e. total volume) water storage. We increased the number of measured lakes by a factor of 300 by using high-resolution Landsat and Sentinel-2 optical remote sensing and ICESat-2 laser altimetry, in addition to radar altimetry from the Topex/Poseidon; Jason-1, Jason-2 and Jason-3; and Sentinel-3 and Sentinel-6 instruments. Historical time series (1984–2020) of water storage could be derived for more than 170 000 lakes globally with a surface area of at least 1 km2, representing 99 % of the total volume of all water stored in lakes and reservoirs globally. Specifically, absolute lake volumes are estimated based on topographic characteristics and lake properties that can be observed by remote sensing. In addition to that, we also generated relative lake volume changes solely based on satellite-derived heights and extents if both were available. Within this dataset, we investigated how many lakes can be measured in near real time (2020–current) in basins worldwide. We developed an automated workflow for near-real-time global lake monitoring of more than 27 000 lakes. The GloLakes historical and near-real-time lake storage dynamics data from 1984 to current are publicly available through https://doi.org/10.25914/K8ZF-6G46 (Hou et al., 2022c) and a web-based data explorer (http://www.globalwater.online, last access: 12 December 2023).
A high-resolution synthesis dataset for multistressor analyses along the US West Coast
Authors: Kennedy Esther G. , Zulian Meghan , Hamilton Sara L. , Hill Tessa M. , Delgado Manuel , Fish Carina R. , Gaylord Brian , Kroeker Kristy J. , Palmer Hannah M. , Ricart Aurora M. , Sanford Eric , Spalding Ana K. , Ward Melissa , Carrasco Guadalupe , Elliott Meredith , Grisby Genece V. , Harris Evan , Jahncke Jaime , Rocheleau Catherine N. , Westerink Sebastian , Wilmot Maddie I. 
Published: January 2024

Abstract. Global trends of ocean warming, deoxygenation, and acidification are not easily extrapolated to coastal environments. Local factors, including intricate hydrodynamics, high primary productivity, freshwater inputs, and pollution, can exacerbate or attenuate global trends and produce complex mosaics of physiologically stressful or favorable conditions for organisms. In the California Current System (CCS), coastal oceanographic monitoring programs document some of this complexity; however, data fragmentation and limited data availability constrain our understanding of when and where intersecting stressful temperatures, carbonate system conditions, and reduced oxygen availability manifest. Here, we undertake a large data synthesis to compile, format, and quality-control publicly available oceanographic data from the US West Coast to create an accessible database for coastal CCS climate risk mapping, available from the National Centers for Environmental Information (accession 0277984) at https://doi.org/10.25921/2vve-fh39 (Kennedy et al., 2023). With this synthesis, we combine publicly available observations and data contributed by the author team from synoptic oceanographic cruises, autonomous sensors, and shore samples with relevance to coastal ocean acidification and hypoxia (OAH) risk. This large-scale compilation includes 13.7 million observations from 66 sources and spans 1949 to 2020. Here, we discuss the quality and composition of the synthesized dataset, the spatial and temporal distribution of available data, and examples of potential analyses. This dataset will provide a valuable tool for scientists supporting policy- and management-relevant investigations including assessing regional and local climate risk, evaluating the efficacy and completeness of CCS monitoring efforts, and elucidating spatiotemporal scales of coastal oceanographic variability.
Searches as data: archiving and sharing search strategies using an institutional data repository
Authors: Rod Alisa , Boruff Jill 
Published: January 2024

Background: By defining search strategies and related database exports as code/scripts and data, librarians and information professionals can expand the mandate of research data management (RDM) infrastructure to include this work. This new initiative aimed to create a space in McGill University’s institutional data repository for our librarians to deposit and share their search strategies for knowledge syntheses (KS).
Case Presentation: The authors, a health sciences librarian and an RDM specialist, created a repository collection of librarian-authored knowledge synthesis (KS) searches in McGill University’s Borealis Dataverse collection. We developed and hosted a half-day “Dataverse-a-thon” where we worked with a team of health sciences librarians to develop a standardized KS data management plan (DMP), search reporting documentation, Dataverse software training, and how-to guidance for the repository.
Conclusion: In addition to better documentation and tracking of KS searches at our institution, the KS Dataverse collection enables sharing of searches among colleagues with discoverable metadata fields for searching within deposited searches. While the initial creation of the DMP and documentation took about six hours, the subsequent deposit of search strategies into the institutional data repository requires minimal effort (e.g., 5-10 minutes on average per deposit). The Dataverse collection also empowers librarians to retain intellectual ownership over search strategies as valuable stand-alone research outputs and raise the visibility of their labor. Overall, institutional data repositories provide specific benefits in facilitating compliance both with PRISMA-S guidance and with RDM best practices.
Penetapan Kadar Boraks Pada Makanan Yang Beredar Di Pasar Semarang Timur Menggunakan Metode Spektrofotometri UV-Vis
Authors: Christina Odilia Dea , Mahesa Sandi , Wirawati Ninik 
Published: January 2024

Boraks (Natrium tetraborate) merupakan zat pengawet berbahaya yang tidak diizinkan digunakan sebagai campuran bahan makanan. Boraks sering disalahgunakan untuk mengawetkan berbagai makanan seperti bakso, mie basah, pisang molen, siomay, lontong, ketupat, pangsit. Dalam jumlah banyak boraks menyebabkan demam, anuria, koma, kerusakan sistem saraf pusat, sianosis, kerusakan ginjal, anemia, muntah, diare. Tujuan penelitian ini ialah untuk mengetahui kadar boraks pada makanan yang sering dikonsumsi yang beredar di pasar Semarang Timur. Sampel makanan yang diteliti adalah bakso, mie basah dan kerupuk yang dijual di Pasar Semarang Timur. Pengujian sampel secara kualitatif ialah uji organoleptis dan KLT. Pada pengujian kuantitatif dengan penetapan kadar menggunakan spektrofotometri UV-Vis dengan menggunakan pelarut ethanol. Sejumlah 3 sampel bakso, 1 sampel mie mengandung Boraks. Kadar boraks pada sampel bakso adalah sebesar B1 0,0052%, B2 0,0045%, B3 0,0046%. Dan kadar boraks pada sampel mie basah adalah sebesar M3 0,0045%.