bluuebunny/crossref_metadata_2025_split huggingface dataset:
P16 Hypopigmented Mycosis Fungoides in a Caucasian child
Authors: Bhadresha Sheena , Moledina Zahra , Tewari Angela 
Published: January 2024

Abstract
We report a case of hypopigmented MF in an 8-year-old Caucasian boy whose skin had been managed as pityriasis alba for a number of years.
On initial presentation to the emergency department, multiple non-itchy scattered hypopigmented macules were incidentally noted on the lower abdomen, groin, lateral flanks and axillae. Physical examination revealed widespread hypopigmented patches. Differential diagnoses included pityriasis alba or post inflammatory hypopigmentation secondary to atopic dermatitis.
He was initially managed with mild to moderate corticosteroids and emollients, but continued to develop multiple atypical asymmetrical macules, particularly on the lower abdomen and groin. Although the skin was responsive to anti-inflammatory treatment, given the progression, a skin biopsy was requested.
A lesional punch biopsy from the abdomen revealed focal lymphocyte exocytosis and interface change at the epidermis. Given the subtle findings the case was discussed at our histopathology MDT meeting. Further specialist review of the histopathology showed clinicopathological correlation in keeping with CD8+ mycosis fungoides (hypopigmented variant). He is currently managed with regular potent topical steroids, 0.1% topical tacrolimus. TL01 phototherapy has been suggested.
Juvenile onset MF constitutes hypopigmented, poikilodermatosis, pityriasis lichenoides-like, folliculotropic, and pigmented purpura- like presentations1. Generally there is no disease progression beyond stage 1A or 1B disease2. Hypopigmented MF is well described in black and Asian skin types but it is also important to appreciate that multiple reoccurring atypical hypopigmented patches in Caucasian skin may also be a variant of hypopigmented MF.
P17 A Multisite Service Evaluation of Paediatric Teleconsultations
Authors: McCusker Sarah , Daly Aoife , King Natalie , Hunjan Manrup , Solman Lea , Burden-Teh Esther , George Susannah , Hale Gordon 
Published: January 2024

Abstract
Paediatric dermatology teleconsultations have become familiar territory since the Covid-19 pandemic. There is a continued drive to provide teleconsultations, with efficiency and cost-saving cited as benefits. Yet, this is not supported by a recent UK-wide survey of health professionals.1 We evaluated practice across two paediatric dermatology centres, to assess time required for teleconsultations.
Data were collected prospectively from paediatric dermatology outpatient consultations for patients &lt;16 years over 2 weeks in March and 4 weeks in September 2022. Consultation type (face-to-face/telephone/video), patient demographics, diagnosis and consultation length were reviewed. Caldicott approval was obtained.
A total of 173 consultations were included. There was a range of diagnoses including eczema (n=60), skin lesions (n=22), vascular lesions (n=28) and other inflammatory skin conditions (n=63). Most consultations were face-to-face (n=108, 62%), while 38% (n=65) were teleconsultations. Median consultation duration was 13 minutes, 45 seconds (range: 2.5min–1hour 5min 2s). Comparison of consultation duration across 3 modalities (face-to-face vs telephone vs video) demonstrated no statistical significance between groups. (H(2)=5.76, P=0.056).
There was a trend toward significance, likely due to 3 face-to-face consultations with duration of &gt;50 minutes. Limitations include relatively small sample size and consultations carried out by few clinicians. Consultation modality is often influenced by case complexity, i.e., more complex consultations are likely to be held face-to-face.
Future work includes a health-economic analysis of teleconsultations to determine if these are cost-effective.
P25 Two cases of multicentric dermatofibrosarcoma Protuberans (DFSP) and adenosine deaminase deficient-severe combined immunodeficiency (ADA-SCID) in a tertiary centre
Authors: Gardner Louis , Dubois Anna , Leech Suzy , Slatter Mary , Gennery Andy , Nademi Zohreh 
Published: January 2024

Abstract
Dermatofibrosarcoma Protuberans (DFSP) are uncommon soft tissue sarcomas that are rarely metastatic though usually high-risk for local aggression and recurrence. DFSP is associated with t(17;22)(q22;q13) chromosomal translocation resulting in COL1A1-platelet-derived growth factorβ(PDGFB) fusion gene(Kesserwan et al. 2009). We present two patients referred to Dermatology at very different ages (patient A 12 years; patient B 6 months) with atrophic plaques and atypical nodules respectively, later demonstrated to be rare cases of multicentric DFSPs. Both were known adenosine deaminase deficient-severe combined immunodeficiency patients (ADA-SCID), associated with multiple additional pathologies(Ochs et al. 2007). Patient A had been treated aged 6 months by undergoing bone marrow transplant (BMT) from an unrelated donor, but did not present with skin lesions until ∼11 years later, whereas Patient B was referred to our centre from another country for BMT and had lesions incidentally detected whilst temporarily in the UK. Histology for both patients demonstrated a paucicellular highly infiltrative spindle cell proliferation in the deep dermis and subcutis and CD34 positivity, consistent with DFSP. Patient A’s tissue was sent to the Northern Genetics Service and the COL1A1-PDGFB fusion gene was detected. Both patients were referred to plastic surgery for multiple excisions (A-3; B-10 lesions). Patient A has since had two further plastic surgery procedures for further or wider excisions. An association between DFSP and ADA-SCID has become more widely reported, though as is highlighted by our two very different cases little is known about timing of presentations, optimal treatment and prognosis.
P26 A life threatening case of Von Zumbusch psoriasis
Authors: Moura Juliana Graciani 
Published: January 2024

Abstract
We report a case of a patient admitted to intensive care with a pustulating skin eruption and haemodynamic compromise with near immediate response to infliximab.
A 16-year-old male with a six-month history of mild plaque psoriasis presented to acute dermatology services with widespread annular pustular eruption, which developed days after a throat infection.
Histopathology was consistent with pustular psoriasis. After an initial partial response, the pustules spread and persisted despite 2-month treatment with topical steroids and ciclosporin (dosed to 4 mg/kg).
With raised inflammatory markers and repeated growth of Staphylococcus aureus, high dose intravenous flucloxacillin was administered. Four hours post infusion the patient became erythrodermic and haemodynamically unstable, requiring management in ICU. Repeat skin biopsy showed features of psoriasis without clear drug reaction features.
Switching classes of antimicrobials and administration of intravenous immunoglobulins led to infection resolution but no significant clinical status change. A multi-disciplinary decision was made to trial intravenous infliximab. This resulted in near-immediate 90% improvement of skin and haemodynamic status. His excellent clinical response has been maintained on adalimumab thus far. Genetic screening for possible mutations associated with pustular psoriasis, including IL36RN and CARD14, are in process.
P28 Congenital Cellular Plexiform Schwannoma Masquerading as Infantile Haemangioma – A Case Report
Authors: Oyedepo Jadesola , Slater Olga , Solman Lea 
Published: January 2024

Abstract

Introduction
Schwannomas are tumours of the peripheral nerve sheath that rarely metastasize but are prone to recurrence. They sometimes occur in the context of syndromes such as neurofibromatosis type 2, Carney complex, and schwannomatosis. Congenital schwannomas appear as an erythematous patch that increases in size in the first few weeks and can be easily mistaken for infantile haemangioma (IH).

Case
A 3-month-old boy was referred to us for suspected IH on the dorsum of his right hand. At birth, he had a slightly erythematous patch but was rapidly increasing in size. Initial ultrasound done locally suggested it may be an IH based on the demonstration of arterial and venous flows. He was otherwise well, and there were no concerns about his growth or development. On examination, he had a firm mass, measuring 3 cm in diameter, that was not clinically in keeping with a vascular anomaly. Our repeated ultrasound showed a solid tumour, possibly fibrosarcoma or myofibroma. Biopsy confirmed cellular plexiform schwannoma and he underwent excision. The results of whole genome sequencing are pending (SMARC-1 and NF), and he remains under the care of the oncology team.

Conclusion
Clinicians assessing infants with “haemangiomas” have a difficult task of differentiating them from other soft tissue tumours. The clinical appearance of vascularity, along with high vascular flow seen on the imaging, cannot always rule out soft tissue tumours. Assessment of firmness can be somewhat subjective, but any vascular lesion that is very firm should be investigated further.
P31 Association of atopic dermatitis with thyroid diseases: a systematic review and meta-analysis
Authors: Chi Ching-Chi , Wang Tzu-Yu 
Published: January 2024

Abstract

Background
Atopic dermatitis (AD) and thyroid diseases have shared immune abnormalities, but their association was largely unclear.

Objective
To systematically examine the association of AD with thyroid diseases.

Methods
A systematic review was performed and the PubMed and Embase databases were searched on 26th August 2023. The risk of bias was assessed by using the Newcastle-Ottawa Scale. A random-effects model meta-analysis was performed and a subgroup analysis based on age groups was executed.

Results
The database searches yielded 205 records after removing duplicates. Nine case-controll studies with 5,367,891 subjects were included. The risk of bias of included was generally low to unclear. AD was significantly associated with thyroid diseases (pooled odds ratio (OR) 1.50, 95% confidence interval (CI) 1.23−1.85; studies = 6; I2 = 85%), which was present in both adults and children (pooled OR being 1.46 (95% CI 1.20−1.78; studies = 2; I2 = 63%) and 3.46 (95% CI 1.15−10.45; studies = 3; I2 = 63%). AD was also associated with Hashimoto disease (pooled OR 2.00, 95% CI 0.91−4.40, I2 = 95%; studies = 2) and Graves disease (pooled OR 2.21, 95% CI 0.59−8.31 I2 = 93%; studies = 2).

Conclusions
AD is associated with an increase of thyroid diseases. AD may be associated with Hashimoto and Graves diseases, but did not reach significance due to high statistical heterogeneity and paucity of evidence. Endocrinological consultation may be considered when AD patients present with thyroid symptoms.
P33 A lichenoid eruption and severe eczema in association with IMAGe syndrome
Authors: O’Connell Garret , Bennett Mary 
Published: January 2024

Abstract
IMAGe syndrome is a rare genetic disorder. IMAGe is an acronym for; (1)Intrauterine restricted growthMetaphyseal dysplasiaCongenital adrenal hypoplasiaGenitourinary abnormalities in males (cryptorchidism, micropenis, and hypospadias)
Diagnosis is established by molecular genetic testing with heterozygous CDKN1C pathogenic mutation or a proband with suggestive findings in the PCNA (proliferating cell nuclear antigen)- binding domain of the maternally expressed allele.
Additional features include characteristic facies (frontal bossing), developmental delay, immunodeficiency, osteoporosis and scoliosis.
Severe, early onset eczema has been described in association with this syndrome. (2)
We present the case of a 15-year-old boy with proven IMAGe syndrome, longstanding history of atopic dermatitis, and new onset lichenoid eruption on the forearms.
What's Hot This Year in Infectious Diseases Clinical Science
Authors: Freiberg Jeffrey A , Wright Patty W 
Published: January 2024

Abstract
The field of infectious diseases saw numerous exciting advances in 2023. Trials of new antibiotics and treatment regimens sought to address rising rates of antimicrobial resistance. Other studies focused on the most appropriate use of currently available treatments, balancing the dual goals of providing effective treatment and impactful antimicrobial stewardship. Improvements in disease prevention were made through trials of both new vaccines and new chemoprophylaxis approaches. Concerning trends this year included increasing rates of invasive group A streptococcal infections, medical tourism-associated cases of fungal meningitis, and the return of locally acquired malaria to the United States. This review covers some of these notable trials and clinical developments in infectious diseases in the past year.
SARS-CoV-2 Antiviral Prescribing Gaps Among Nonhospitalized High-Risk Adults
Authors: Levy Matthew E , Burrows Evanette , Chilunda Vanessa , Pawloski Pamala A , Heaton Phillip R , Grzymski Joseph , Goldman Jason D , McEwen Lisa M , Wyman Dana , Dei Rossi Andrew , Dai Hang , Isaksson Magnus , Washington Nicole L , Basler Tracy , Tsan Kevin , Nguyen Jason , Ramirez Jimmy , Sandoval Efren , Lee William , Lu James , Luo Shishi 
Published: January 2024

Abstract
Within a multistate clinical cohort, SARS-CoV-2 antiviral prescribing patterns were evaluated from April 2022–June 2023 among nonhospitalized patients with SARS-CoV-2 with risk factors for severe COVID-19. Among 3247 adults, only 31.9% were prescribed an antiviral agent (87.6% nirmatrelvir/ritonavir, 11.9% molnupiravir, 0.5% remdesivir), highlighting the need to identify and address treatment barriers.
Omega-3 fatty acids for cardiovascular event lowering
Authors: Kaur Gurleen , Mason R Preston , Steg Ph Gabriel , Bhatt Deepak L 
Published: January 2024

Abstract
Low-density lipoprotein cholesterol (LDL-C) is the main target for therapeutics aimed at reducing the risk of atherosclerotic cardiovascular disease (ASCVD) and downstream cardiovascular (CV) events. However, multiple studies have demonstrated that high-risk patient populations harbour residual risk despite effective LDL-C lowering. While data support the causal relationship between triglycerides and ASCVD risk, triglyceride-lowering therapies such as omega-3 fatty acids have shown mixed results in CV outcomes trials. Notably, icosapent ethyl, a purified formulation of eicosapentaenoic acid (EPA), has garnered compelling evidence in lowering residual CV risk in patients with hypertriglyceridaemia and treated with statins. In this review, we summarize studies that have investigated omega-3-fatty acids for CV event lowering and discuss the clinical implementation of these agents based on trial data and guidelines.
Dissecting the complex genetic basis of pre- and post-harvest traits in Vitis vinifera L. using genome-wide association studies
Authors: García-Abadillo Julian , Barba Paola , Carvalho Tiago , Sosa-Zuñiga Viviana , Lozano Roberto , Carvalho Humberto Fanelli , Garcia-Rojas Miguel , Salazar Erika , y Sánchez Julio Isidro 
Published: January 2024

Abstract
Addressing the pressing challenges in agriculture necessitates swift advancements in breeding programs, particularly for perennial crops like grapevines. Moving beyond the traditional biparental quantitative trait loci (QTL) mapping, we conducted a genome-wide association study (GWAS) encompassing 588 Vitis vinifera L. cultivars from a Chilean breeding program, spanning three seasons and testing 13 key yield-related traits. A strong candidate gene, Vitvi11g000454, located on chromosome 11 and related to plant response to biotic and abiotic stresses through jasmonic acid signaling, was associated with berry width and holds potential for enhancing berry size in grape breeding. We also mapped novel QTL associated with post-harvest traits across chromosomes 2, 4, 9, 11, 15, 18, and 19, broadening our grasp on the genetic intricacies dictating fruit post-harvest behavior, including decay, shriveling, and weight loss. Leveraging gene ontology annotations, we drew parallels between traits and scrutinized candidate genes, laying a robust groundwork for future trait-feature identification endeavors in plant breeding. We also highlighted the importance of carefully considering the choice of the response variable in GWAS analyses, as the use of best linear unbiased estimators (BLUEs) corrections in our study may have led to the suppression of some common QTL in grapevine traits. Our results underscore the imperative of pioneering non-destructive evaluation techniques for long-term conservation traits, offering grape breeders and cultivators insights to improve post-harvest table grape quality and minimize waste.
Divergent Acute and Enduring Changes in 50-kHz Ultrasonic Vocalizations in Rats Repeatedly Treated With Amphetamine and Dopaminergic Antagonists: New Insights on the Role of Dopamine in Calling Behavior
Authors: Serra Marcello , Costa Giulia , Onaivi Emmanuel , Simola Nicola 
Published: January 2024

Abstract

Background
Rats emit 50-kHz ultrasonic vocalizations (USVs) in response to nonpharmacological and pharmacological stimuli, with addictive psychostimulants being the most effective drugs that elicit calling behavior in rats. Earlier investigations found that dopamine D1-like and D2-like receptors modulate the emission of 50-kHz USVs stimulated in rats by the acute administration of addictive psychostimulants. Conversely, information is lacking on how dopamine D1-like and D2-like receptors modulate calling behavior in rats that are repeatedly treated with addictive psychostimulants.

Methods
We evaluated the emission of 50-kHz USVs in rats repeatedly treated (×5 on alternate days) with amphetamine (1 mg/kg, i.p.) either alone or together with (1) SCH 23390 (0.1–1 mg/kg, s.c.), a dopamine D1 receptor antagonist; (2) raclopride (0.3–1 mg/kg, s.c.), a selective dopamine D2 receptor antagonist; or (3) a combination of SCH 23390 and raclopride (0.1 + 0.3 mg/kg, s.c.). Calling behavior of rats was recorded following pharmacological treatment, as well as in response to the presentation of amphetamine-paired cues and to amphetamine challenge (both performed 7 days after treatment discontinuation).

Results
Amphetamine-treated rats displayed a sensitized 50-kHz USV emission during repeated treatment, as well as marked calling behavior in response to amphetamine-paired cues and to amphetamine challenge. Antagonism of D1 or D2 receptors either significantly suppressed or attenuated the emission of 50-kHz USVs in amphetamine-treated rats, with a maximal effect after synergistic antagonism of both receptors.

Conclusions
These results shed further light on how dopamine transmission modulates the emission of 50-kHz USVs in rats treated with psychoactive drugs.
Mapping as a Critical Making Practice in International Relations
Authors: Ragazzi Francesco 
Published: January 2024

Abstract
How “critical” is mapping as a method in international relations (IR)? Critical approaches have fundamentally changed the practices of mapmaking in IR. They have replaced geopolitical representations of a world divided into territorial states with notions of fields, networks, flows, rhizomes, and assemblages. This shift is both conceptual and methodological: It has led to the introduction of new methods of representation, such as multiple correspondence analysis and network analysis. These new methods have, however, been subjected to a strong critique. They are accused of reproducing the very logics of power that they aim to question, and flatten the knowledge they aim to represent. There would be, as the argument goes, an inescapable theoretical and political bias embedded in these methods. This article engages with this debate, which is ultimately about the ontological and epistemological status of mathematical methods of visual representation and, more broadly, about the role of “making” in IR. It argues that practices of mapmaking can still be designed to function as critical tools. To illustrate this argument, this article draws on ongoing research on biometric mass surveillance as part of the Security Vision project.
O03 Phenotypic antimicrobial resistance to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients
Authors: Verkaik Nelianne J , Wielders Cornelia C H , den Boer Hans , Langerak Diana , Vogel Marius , Witteveen Sandra , de Haan Angela , Bos Jeroen , van Westreenen Mireille , Notermans Daan W , Hendrickx Antoni P A 
Published: January 2024

Abstract

Background
Since March 2022, there has been an emergence of MDR microorganisms (MDRO) in Europe because of an increasing number of Ukrainian patients with MDRO. The goal was to collect large-scale phenotypic susceptibility data to assess implications for clinical practice.

Methods
For 122 MDRO (carbapenemase-producing Enterobacterales (CPE, n=96), Pseudomonas aeruginosa CPPA (n=20), carbapenem-resistant Acinetobacter baumannii-calcoaceticus (CRAB, n=6), collected from March to December 2022, broth microdilution (BMD), fosfomycin agar dilution, gradient strip ampicillin/sulbactam, sulbactam/durlobactam, ceftazidime-avibactam-aztreonam and disc diffusion (DD) cefiderocol was performed. Epidemiological data was obtained as part of mandatory reporting by Municipal Health Services (CPE), and surveillance questionnaires (CPPA/CRAB).

Results
Admission at a Ukrainian hospital in the last year was a risk factor for acquiring MDRO. Of all isolates, 65% (79/122) were blaNDM-positive. For meropenem, aminoglycosides, ceftazidime-avibactam, ceftolozane-tazobactam and imipenem-relebactam susceptibility rates were low (0-30%). For cefiderocol, results depended on reading with or without microcolonies, applying EUCAST or CLSI breakpoints, and whether DD or BMD was used: e.g. for Klebsiella pneumoniae, 30%–97% were susceptible, depending on these variables. For colistin, 103/111 (93%) non-intrinsically resistant CPE/CPPA/CRAB isolates were susceptible. For the majority of CPE, a low MIC of &lt;0.5 mg/L was measured for tigecycline and ceftazidime-avibactam-aztreonam. For CPPA, cefiderocol tested susceptible in 65%–100% of isolates. For CRAB, ampicillin/sulbactam MICs were ≥128 mg/L, for sulbactam/durlobactam 1–2 mg/L.

Conclusions
There is extensive phenotypic resistance to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients. For cefiderocol, interpretation of susceptibility results depends on a number of variables. In case of infection, treatment options are colistin, cefiderocol (CPE/CPPA/CRAB), tigecycline (CPE/CRAB), ceftazidime-avibactam-aztreonam (CPE), sulbactam/durlobactam (CRAB).