bluuebunny/crossref_metadata_2025_split huggingface dataset:
Group-based exercise for Parkinson’s: a qualitative study of participants’ and partners’ experiences from a community-university collaboration
Authors: Ferrusola-Pastrana Anna , Fullerton Christopher L , Meadows Stephen N 
Published: January 2024

Abstract
Community-based exercise programmes (CBEPs) are a practical and viable approach for providing people with Parkinson’s disease (PwP) with the opportunity to exercise as an ancillary therapeutic benefit to pharmacological management. This study aimed to explore the views and experiences of exercising participants (PwP) and non-participating partners involved in an exercise class delivered through a community-university partnership. Two separate focus group discussions were conducted: one with class participants (PwP: n = 7, H&Y scale I to III), and the other with non-participating partners of PwP (n = 4). The data were then thematically analyzed. Results suggest that a range of physical, psychological, and social factors were perceived to influence engagement: 1) Actively taking control, 2) Exercise is medicine for the mind and body, and 3) Working together as a team. Participants and partners felt that the support from the group, including the instructors and student volunteers, empowered and supported PwP to proactively self-manage their health, enjoy exercise in an inclusive group setting, and develop strong social connections with others in the local Parkinson’s community. Support for exercise from healthcare professionals was identified as both an enabler and barrier to participation. Critical reflections concerning its sustainability are offered, including implications for how exercise is considered as medicine for PwP, as well as some practical recommendations to galvanize community participation and provide inclusive and viable exercise opportunities for PwP.
Repeated γ Irradiation and Thermal Annealing via Built-In Thermo-Electric Coolers of Si Avalanche Photodiodes
Authors: Wu Shuin Jian , Chowdhury Arya , Soe Moe Thar , Ling Alexander 
Published: January 2024

Abstract
When operating in space, on-board Silicon Geiger-Mode Avalanche Photodiodes (GM-APDs) are exposed to radiation damage that result in an increase in dark count rates. Thermal annealing has been found to mitigate the damage, although prior studies have largely focused on annealing following a single session of proton irradiation. This work reports that thermal annealing can be performed simply with the built-in thermo-electric coolers of the GM-APDs. Annealing was also done in 10 min intervals for a clearer view of the recovery curve. Mitigation of damage from repeated γ radiation was observed from the: (1) halving of the increase in dark count rates on average and (2) outperformance of room temperature annealing (25°C) by 33%. Additionally, we show that heavy doses of γ radiation (21 krad) have a probability of causing Random Telegraph Signals in GM-APDs that can be suppressed by lowering the operating temperature.
Prevalence and molecular characterization of Trichomonas gallinae from pigeons in Anhui, China
Authors: Zhang Yilei , Lu Zhenxiao , Liu Zhenzhen , Zhou Yuhan , Xiao Guodong , Opeyemi Ayanniyi Olalekan , Jin Sihua , Li Yongsheng , Liu Tao , Wu Qiong , Sun Xingdong , Xu Qianming , Zhang Qingxun , Yang Congshan 
Published: January 2024

Abstract
Trichomonas gallinae, a protozoan parasite causing avian trichomonosis, exhibits a widespread global prevalence. It primarily affects the upper digestive tract of birds and has resulted in significant ecological problems worldwide. This study aimed to investigate the prevalence and genotypes of T. gallinae in Anhui Province, China. A total of 1612 oropharyngeal swab samples were collected from pigeon farms in Anhui Province to determine the prevalence of T. gallinae infection. The results revealed 565 (35.1%) positive samples of T. gallinae. Significant differences in infection rates were observed among different regions and age groups. Furthermore, the ITS1/5.8S/ITS2 region was amplified, sequenced, and subjected to phylogenetic analysis. Genotypes A and B of T. gallinae were identified, and genotype B was the dominant genotype in Anhui Province. This is the first report on the prevalence and molecular characterization of T. gallinae in Anhui Province, China. Additionally, we integrated reports on the prevalence and genotype of T. gallinae in relevant provinces in China.
Investigation of the prevalence of Brucella antibodies and field strains in immunized dairy herds in Lingwu, Ningxia
Authors: Shi Yong , Cui Yimeng , Wudong Gaowa , Li Shengnan , Yuan Ye , Zhao Danyu , Yin Shurong , Diao Ziyang , Li Bin , Zhou Dong , Li Xuejun , Wang Zhanlin , Zhang Fengxia , Xie Min , Zhao Zehui , Wang Aihua , Jin yaping 
Published: January 2024

Abstract
Background Brucella 19 strain vaccines are widely used to prevent brucellosis in cattle. The vaccine antibodies are generally acknowledged to persist for less than 12 months after immunization. The real rate of persistent antibodies may be a difference because of different feeding management and immunization schedules. The effect of vaccine immunization and the correlation between the persistence of antibodies induced by immunization and field strain infection remains unclear in the northwest of China.
Results We revealed that Brucella A19 vaccine antibodies persist in dairy herds for more than 12 months. We established a PCR method for identifying both Brucella A19 and non-A19 strains, resulting in the detection of 10 field strains of Brucella abortus from vaginal swab samples collected from 1,537 dairy cows. We analyzed the rates of seropositivity and herd seropositive rates in dairy cattle in Lingwu City from 2021 to 2023. By employing a mathematical expectation strategy, we completed testing of 1537 samples after conducting only 306 tests of pools of six samples, thereby reducing the workload by 80.1%.
Conclusion We propose that the detection of antibodies in cattle vaccinated with the A19 vaccine more than 12 months previously should not be solely relied upon as a diagnostic basis for brucellosis, and it is essential to combine this approach with PCR analysis to specifically identify field strains. Timely detection of Brucellain aborting livestock was identified as an efficient strategy for diagnosis. This research provides valuable data for the prevention and control of brucellosis in immunized cattle herds, as well as serving as a reference method for investigating and diagnosing brucellosis in livestock vaccinated in other regions.
Understanding the Public Stigma of Mental Illness: A Mixed-Methods, Multi-Level, Exploratory Triangulation Study.
Authors: Walsh Daniel Alexander Benjamin , Foster Juliet 
Published: January 2024

Abstract

Background: This study examines the role of themata in understanding mental health-related stigma. It is motivated by the need for alternative theoretical-methodological approaches beyond the dominant frameworks in education and contact-based anti-stigma public health efforts, which have shown mixed and unintended consequences. Specifically, it addresses the need for a more nuanced framework in stigma research, one that is sensitive to the dialogues through which people relate themselves to mental health and stigma in context.
Methods: The research employs an exploratory mixed-methods approach, including the analysis of 529 news reports, 20 focus group discussions, and 19 one-to-one interviews, all concerning representations of shared living arrangements with someone perceived to have experiences of mental illness. Thematic analysis and natural language processing are used within a convergent triangulation design to analyze the data.
Results: We found that mental health and illness were communicated through an overarching Self/Other thema and five subordinate themata: normal/abnormal, harm/non-harm, bounded/non-bounded, and moral/immoral. Despite familiarity with psychological distress and 'modern' explanations of mental illness, concerns about social identity motivated representations of mental illness as a predominantly permanent, negative form of personhood marked by abnormality, harm, distance, and immorality. Additionally, concerns about personal vulnerability, including historically rooted fears of contagion, motivated distancing representations of mental illness, rather than neutral portrayals.
Conclusions: Themata have under-developed theoretical and methodological potential for addressing mental health-related stigma, particularly in their ability to describe the dynamic ways in which culture motivates people to both resist and reproduce stigma, partly through ambivalences, absences, tensions, and ambiguities in representation. A critical discussion is provided on how themata may support ecological strategies in mental health campaigns over generic models, emphasizing the need to understand group knowledge and contact dynamics to mitigate adverse effects.
Investigation of dye removal from water solutions using raw clay and expanded clay ball: Kinetic, isotherm, and thermodynamic
Authors: Tulun Şevket 
Published: January 2024

Abstract
This study investigated the removal of methylene blue (MB) dye from aqueous solutions using raw clay (RC) and expanded clay ball (ECB) with different particle sizes ( = < 200 mesh, and > 200 mesh). A series of studies such as operating time (1 to 90 min), RC and ECB dose (0.1 to 4g/L), pH (2 to 10), mixing speed (60 to 180 rpm) and temperature (20 to 45°C) were additionally conducted through the use of a batch system in order to optimize the process. Additionally, this study investigated the concepts of adsorption kinetics, isotherms, and thermodynamics of MB. RC and ECB were characterized through distinct physical – chemical methods including scanning electron microscopy (SEM), energy dispersive x ray spectrometer (EDAX), Fourier transform infrared spectroscopy (FTIR). The structural changes in the surface morphology of ECB caused it to exhibit lower adsorption capacity than RC. The removal occurred rapidly in the first few minutes. RC (20 min.) reached equilibrium faster than ECB (30 min.). Under optimal conditions, removal efficiencies of > 200 mesh RC, =<200 mesh RC, > 200 mesh ECB, =<200 mesh ECB were obtained as 97.5%, 95.76%, 39.26%, 91.81%, respectively. The results show that the pseudo-second order (PSO), with R2 ranging from 0.69 to 1, and the Langmuir isotherm model, with a good fit for the MB removal for all combinations, are in agreement with the experimental data According to the study results, the process was carried out endothermic and physical.
Grayscale mapping of infrared images based on end-to-end deep neural networks
Authors: Cheng Lin , Hong Wenqing , Wang Xiaodong , Zhang Chen 
Published: January 2024

Abstract
The grayscale mapping of infrared images is an important research direction in the field of infrared imaging. A fast and scene-adaptive grayscale mapping method is crucial for visualizing high dynamic range original infrared images in various standard dynamic range output devices, such as printers and standard monitors. At present, mainstream grayscale mapping methods can only handle high dynamic range images in limited scenes and require extensive parameter adjustments to generate high-quality mapping results. In this paper, we propose a fast, parameter-free, and scene-adaptive grayscale mapping method to address this issue, which can achieve high subjective quality mapping results. Our model not only adapts to various categories of scenes, but also resolves the issues of insufficient contrast and significant loss of details in the grayscale mapping of high dynamic range infrared images. We explored the different impacts of the loss functions and normalization layers in the model on the mapping effect, and ultimately adopted L1 loss, perceptual loss, and batch normalization to accomplish our task. To ensure the production of high-quality mapping results, we used the objective metric of high dynamic range image quality assessment, specifically the tone mapping image quality index, to identify target images for training our model. We evaluated our results from both quantitative and qualitative perspectives, showcasing the high-quality output images generated by our model in a wide range of real-world scenarios. This substantiates the superiority of our approach.
Effect of Humic Acid Applied With Farmyard Manure on Nutrients Use Efficiency and Wheat Yield
Authors: Bibi Sobia , Mussarat Maria , Muhammad Dost , - Shafi Ullah , Murad Zaryab 
Published: January 2024

Abstract
The use of chemical fertilizers for getting higher yield of crop imposes negative effects on soil properties. The application of organic amendments in combination with synthetic fertilizer to improve the growth of crop hence reduce its effect on soil has become imperative. A field experiment was carried out at research farm of The University of Agriculture Peshawar, to study the effect of Humic acid (HA) and farmyard manure (FYM) along with chemical fertilizers on N, P, and K use efficiency and yield of wheat crop during rabi 2020-21. Humic acid and FYM was applied at the rate of 10 kg ha-1 and 10 tons ha-1 respectively while the source of nitrogen was applied at the rate of 90 kg ha-1 and 120 kg ha-1, the source of phosphorous was applied at the rate of 60 kg ha-1 and 90 kg ha-1 and the source of potassium was applied at the rate of 45 kg ha-1 and 60 kg ha-1. Treatments were arranged in randomized complete block design with three replications. Application of HA and FYM along with different levels of synthetic fertilizers significantly improved plant height, biological yield and 1000-grain weight as compared to control. The results indicated that the application of synthetic fertilizers alone significantly increased grain yield from 2535 kg ha-1 in control to 3495 kg ha-1 that was further improved to 3717 kg ha-1 when combined with HA and to 3949 kg ha-1 when applied with FYM. The combined application of FYM and HA with 75% NPK resulted in higher yield than 100% NPK suggesting fertilizers reduction with improvement in yield. Furthermore, the study assessed the total nutrient uptake and use efficiency, indicating that FYM and HA application with NPK fertilizer enhanced the uptake of N, P, and K by wheat plants. Notably, the highest nutrient use efficiency was recorded in plots treated with FYM and HA along with 75% NPK fertilizer. These findings suggest the potential of integrated nutrient management practices to enhance wheat productivity and soil fertility.
Familial exudative vitreoretinopathy caused by CTNNB1 gene mutation in a Chinese family: A case report
Authors: Wang Yanan , Chang Yujie , Chai Yuqiong , Lei Hongtao , Yan Weiyan , Zang Weiwei 
Published: January 2024

Abstract

Background
Familial exudative vitreoretinopathy (FEVR) is an inherited disorder of retinal vascularization insufficiency caused primarily by genetic mutations. So far, FEVR has been less reported in the Chinese population. This study will provide a case of FEVR due to CTNNB1 splice mutation in a Chinese family, which will be helpful for genetic counseling and clinical diagnosis.
Case presentation:
We analyzed a case of familial exudative vitreoretinopathy of Chinese Han origin using whole-exome sequencing. The results showed that the patient presents with neurodevelopmental disorders accompanied by spastic diplegia and visual impairment, as well as FEVR. Whole exome sequencing revealed a splicing mutation of c.1060 + 1G > A in the CTNNB1 gene of the patient. This may be the reason for the pathogenicity of FEVR observed in this patient. Our analysis indicates that this variant produces a truncated protein that contributes to the development of the disease. Genetic testing confirmed the FEVR diagnosis of patients from the study pedigree.
Conclusions
The c.1060 + 1G > A heterozygous mutation in the CTNNB1 gene can lead to FEVR disease, which expands the spectrum of CTNNB1 gene functional loss mutations in the Chinese population.
Behavioral and electrophysiological study in Colossoma macropomum treated with different concentrations of Nepeta cataria oil in an immersion bath revealed a therapeutic window for anesthesia
Authors: Santos Murilo Farias dos , Nascimento Lorena Meirelis do , Paz Clarissa Araújo da , Câmara Tays Mata , Motomya Yan Kenzo Monteiro , Ferreira Rayllan Cunha , Deiga Yris Silva , Santos Erika Monteiro , Cantanhêde Sildiane Martins , Amado Lílian Lund , Hamoy Moisés 
Published: January 2024

Abstract

The purpose of this study was to characterize the activity of essential oils from Nepeta Cataria (EON) at concentrations of 125 µí µí°¿.L-1 , 150 µí µí°¿.L-1 , 175 µí µí°¿.L-1 and 200 µí µí°¿.L-1 on the behavior of loss of the posture reflex and recovery of the posture reflex and electrocardiographic activity and recording of the opercular beat of Colossoma macropomum during immersion bathing for a period of 5 minutes, in order to obtain a window for safe use during anesthesia. The fish (23.38 ± 3.5g) were assigned to the following experiments: Experiment 1 (latency to loss and recovery of the posture reflex): a) 125 µí µí°¿.L-1 b)150 µí µí°¿.L-1 , c) 175 µí µí°¿.L-1 and d) 200 µí µí°¿.L-1 (n=9) per group. Experiment 2 (electrocardiographic and heartbeat recordings): a) Control group; b) Vehicle control group (2 ml of alcohol per liter of water), c) 125 µí µí°¿.L-1 d) 150 µí µí°¿.L-1 , e) 175 µí µí°¿.L-1 and f) 200 µí µí°¿ .L-1 (n=9), per group. All the concentrations used showed efficacy in inducing loss of the posture reflex and reversibility with recovery of the posture reflex, but the electrocardiographic recordings indicated morphographic changes such as bradycardia during induction and p-wave apiculation during recovery at the highest concentrations tested. In this way, we suggest a safe use window for short-term anesthesia with EON in the concentration range of 125 µí µí°¿.L-1 to 150 µí µí°¿.L-1 for juvenile Colossoma macropomum.
Management of Pancreatic and Duodenal Trauma in Childhood: A University Hospital Experience Over a Ten-Year Period
Authors: Mansiroglu M.D. , Cesur M.D. , Firinci a/Prof. , Caglar a/Prof. , Yigiter Prof. , Salman Prof. 
Published: January 2024

Abstract
Purpose
Duodenal/pancreatic injuries occur in less than 10% of intra-abdominal injuries in pediatric blunt trauma. Isolated duodenal/pancreatic injuries occur in two-thirds of cases, while combined injuries occur in the remaining. This study aimed to investigate pediatric patients with pancreatic and duodenal trauma.
Methods
Data from 31 patients admitted to Atatürk University, Medical Faculty, Department of Pediatric Surgery for pancreatic/duodenal trauma between 2010–2019 were retrospectively analyzed. Age/gender, province of origin, duration before hospital admission, trauma type, injured organs, injury severity, diagnostic & therapeutic modalities, complications, hospitalization duration, blood transfusion requirement, and mortality rate were recorded.
Results
24 patients were male, and 7 were female. The mean age was 9 years. The leading cause was bicycle accidents, with 12 cases, followed by traffic accidents/bumps, with 7 cases each. Comorbid organ injuries accompanied 18 cases. Duodenal trauma was most commonly accompanied by liver injuries (4/8), whereas pancreatic injury by pulmonary injuries (7/23). Serum amylase at initial hospital presentation was elevated in 83.9% of the patients. 30 patients underwent abdominal CT, and FAST was performed in 20. While 54.8% of the patients were conservatively managed, 45.2% underwent surgery.
Conclusion
Because of the anatomical proximity of the pancreas and the duodenum, both organs should be considered being co-affected by a localized trauma. Radiologic confirmation of perforation in duodenal trauma, and an intra-abdominal pancreatic pseudocyst in pancreatic trauma, are the most critical surgical indications of pancreaticoduodenal trauma. Conservative management’s success is increased in the absence of duodenal perforation and cases of non-symptomatic pancreatic pseudocyst.
Cohesin loss and MLL-AF9 are not synthetic lethal in murine hematopoietic stem and progenitor cells
Authors: Meyer Alison , Stelloh Cary , Zhu Nan , Rao Sridhar 
Published: January 2024

Abstract
Objective
As cohesin mutations are rarely found in MLL-rearranged acute myeloid leukemias, we investigated the potential synthetic lethality between cohesin mutations and MLL-AF9 using murine hematopoietic stem and progenitor cells.
Results
Contrary to our hypothesis, a complete loss of Stag2 or haploinsufficiency of Smc3 were well tolerated in MLL-AF9-expressing hematopoietic stem and progenitor cells. Minimal effect of cohesin subunit loss on the in vitro self-renewal of MLL-AF9-expressing cells was observed. Despite the differing mutational landscapes of cohesin-mutated and MLL fusion AMLs, previous studies showed that cohesin and MLL fusion mutations similarly drive abnormal self-renewal through HOXA gene upregulation. The utilization of a similar mechanism suggests that little selective pressure exists for the acquisition of cohesin mutations in AMLs expressing MLL fusions, explaining their lack of co-occurrence. Our results emphasize the importance of using genetic models to test suspected synthetic lethality and suggest that a lack of co-occurrence may instead point to a common mechanism of action between two mutations.
3d Models as a Source for Neuroanatomy Education: a Stepwise White Matter Dissection Using 3d Images and Photogrammetry Scans
Authors: Oliveira André de Sá Braga , Fernandes João Vítor Andrade , Figueiredo Vera Louise Freire de Albuquerque , Leonel Luciano César Pereira Campos , Bauman Megan M. J. , Link Michael J. , Peris-Celda Maria 
Published: January 2024

Abstract
White matter dissection (WMD) involves isolating bundles of myelinated axons in the brain and serves to gain insights into brain function and neural mechanisms underlying neurological disorders. While effective, cadaveric brain dissections pose certain challenges mainly due to availability of resources. Technological advancements, such as photogrammetry, have the potential to overcome these limitations by creating detailed three-dimensional (3D) models for immersive learning experiences in neuroanatomy. Objective: This study aimed to provide a detailed step-by-step WMD captured using two-dimensional (2D) images and 3D models (via photogrammetry) to serve as a comprehensive guide for studying white matter tracts of the brain. One formalin-fixed brain specimen was utilized to perform the WMD. The brain was divided in a sagittal plane and both cerebral hemispheres were stored in a freezer at -20°C for 10 days, then thawed under running water at room temperature. Micro-instruments under an operating microscope were used to perform a systematic lateral-to-medial and medial-to-lateral dissection, while 2D images were captured and 3D models were created through photogrammetry during each stage of the dissection. Dissection was performed with comprehensive examination of the location, main landmarks, connections, and functions of the white matter tracts of the brain. Furthermore, high-quality 3D models of the dissections were created and housed on SketchFab®, allowing for accessible and free of charge viewing for educational and research purposes. Our comprehensive dissection and 3D models have the potential to increase understanding of the intricate white matter anatomy and could provide an accessible platform for the teaching of neuroanatomy.