bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homozygosity for the 168His variant of the minor histocompatibility antigen HA‐1 is associated with reduced risk of primary Sjögren's syndrome
Authors: Harangi Mariann , Kaminski Wolfgang E. , Fleck Martin , Orsó Evelyn , Zeher Margit , Kiss Emese , Szekanecz Zoltán , Zilahi Erika , Marienhagen Jörg , Aslanidis Charalampos , Paragh György , Bolstad Anne Isine , Jonsson Roland , Schmitz Gerd 
Published: December 2004

AbstractThe genes for the human ATP‐binding cassette (ABC) transporter ABCA7 and the minor histocompatibility antigen HA‐1 are juxtaposed in close proximity on chromosome 19p13.3. The multispan transmembrane protein ABCA7 contains an extracellular domain that is recognized by antisera from patients with Sjögren's syndrome (“Sjögren‐epitope”). Recent work from our laboratory demonstrating the involvement of ABCA7 in cellular ceramide and phosphatidylserine export suggests a role for this transporter in programmed cell death. In HA‐1, a protein of unknown function, a His/Arg polymorphism (His168Arg), which constitutes the immunologic target for HA‐1‐specific cytotoxic T cells, has been causatively linked to graft‐versus‐host disease after allogeneic stem cell transplantation. Because these findings suggest a potential implication of ABCA7 and HA‐1 in immune processes, we tested the hypothesis that allelic variants in both genes are associated with autoimmune disorders. We identified a total of 31 exonic single‐nucleotide polymorphisms (SNP) in the ABCA7/HA‐1 gene complex, nine of which represent non‐synonymous nucleotide alterations. Genotypes of ABCA7 and HA‐1 SNP were determined in three distinct Caucasian populations of patients with primary Sjögren's syndrome and ethnically matched controls. Comparison of allele frequencies between these groups revealed that the incidence of the HA‐1 168His allele is significantly lower in Sjögren's syndrome patients than in controls (p<0.003). In contrast, the frequencies of all ABCA7 allelic variants and additional HA‐1 polymorphisms were similar in patients and controls. In cohorts of patients with systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis, no significant differences in the frequencies of ABCA7 and HA‐1 allelic variants were observed relative to controls. Our results suggest that the HA‐1 168His variant is associated with reduced susceptibility to primary Sjögren's syndrome.
Hardware architecture for hierarchical segmentation in foveal images
Authors: Coslado F. J. , Camacho P. , González M. , Sandoval F. 
Published: December 2004

AbstractFoveal sensors can substantially increase the performance of active vision systems because of their ability to handle wide field of view and simultaneously reduce the data/bandwidth with space variant sensing. To process the multiresolution images and associated data structures, a new hierarchical processing has been applied to minimize data communications and retrieval. In this article, we present a hardware platform that implements a level sequential segmentation algorithm in one of these hierarchical structures based on a Cartesian lattice topology. The platform operates in real time, at speeds in the range of 25 to 85 frames/s, using a digital uniform‐resolution camera as the source to generate and process the multiresolution images. © 2004 Wiley Periodicals, Inc. Int J Imaging Syst Technol 14, 153–166, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ima.20019
Synthetic‐aperture technique for high‐resolution composite imaging of the inside walls of tubular specimens
Authors: Lee Hua 
Published: December 2004

AbstractHigh‐resolution survey of the inside walls of tubular specimens is a unique application of synthetic‐aperture composite imaging. This article describes the data acquisition process, 3D motion estimation and compensation, image registration, and superposition for the formation of high‐resolution composite images from conventional video sequences. Experiment results from the survey of an oil well are used to demonstrate the capability of the technique. © 2004 Wiley Periodicals, Inc. Int J Imaging Syst Technol 14, 167–169, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ima.20020
Charge donation to and dearomatization of benzene attending complexation: DFT estimates of binding energies of TpMXO(L) with benzene, for Tp = hydridotris(pyrazolyl) borate, MXO = MoNO, ReCO, and WNO, and L = ammonia, N‐methylimidazole, pyridine, phosphine, methyl isocyanide, and carbon monoxide
Authors: Harman W. Dean , Trindle Carl 
Published: December 2004

AbstractBy density functional methods we characterize the bonding and charge distribution in complexes of benzene with dearomatizing agents tpReCO(L), tpMoNO(L), and tpWNO(L), where tp = hydrido Tris (pyrazolyl)borate), for a range of ligands L. Our LSDA and B3LYP density functional calculations use the Spartan LACVP+ basis and pseudopotential on Re, Mo, and W and 6‐31G* on light atoms. The binding energy is strongly dependent on the nature of the ligand L, being greatest for L = ammonia and N‐methylimidazole and weakest for CH3NC and CO. We find a correlation between strength of binding and electron transfer from the dearomatizing agents toward benzene. For the most strongly bound systems we find substantial (up to 500 millielectrons) charge transfer towards benzene, while for the most weakly bound systems charge is withdrawn from benzene. Structural details illustrate the ability of Re, Mo, and W species to dearomatize complexed benzene, which is extensive for all but the most weakly bound species with L = MeNC and CO. Re and W dearomatizing agents, which are computed and observed to form stable complexes with benzene, may be economic alternatives to osmium dearomatizing agents. © 2004 Wiley Periodicals, Inc. J Comput Chem 26: 194–200, 2005
Theoretical study and rate constant calculation for the reactions of SH (SD) with Cl2, Br2, and BrCl
Authors: Wang Li , Liu Jing‐Yao , Li Ze‐Sheng , Sun Chia‐Chung 
Published: December 2004

AbstractThe mechanisms of the SH (SD) radicals with Cl2 (R1), Br2 (R2), and BrCl (R3) are investigated theoretically, and the rate constants are calculated using a dual‐level direct dynamics method. The optimized geometries and frequencies of the stationary points are calculated at the MP2/6‐311G(d,p) and MPW1K/6‐311G(d,p) levels. Higher‐level energies are obtained at the approximate QCISD(T)/6‐311++G(3df, 2pd) level using the MP2 geometries as well as by the multicoefficient correlation method based on QCISD (MC‐QCISD) using the MPW1K geometries. Complexes with energies less than those of the reactants or products are located at the entrance or the exit channels of these reactions, which indicate that the reactions may proceed via an indirect mechanism. The enthalpies of formation for the species XSH/XSD (X = Cl and Br) are evaluated using hydrogenation working reactions method. By canonical variational transition‐state theory (CVT), the rate constants of SH and SD radicals with Cl2, Br2, and BrCl are calculated over a wide temperature range of 200–2000 K at the a‐QCISD(T)/6‐311++G(3df, 2pd)//MP2/6‐311G(d, p) level. Good agreement between the calculated and experimental rate constants is obtained in the measured temperature range. Our calculations show that for SH (SD) + BrCl reaction bromine abstraction (R3a or R3a′) leading to the formation of BrSH (BrSD) + Cl in a barrierless process dominants the reaction with the branching ratios for channels 3a and 3a′ of 99% at 298 K, which is quite different from the experimental result of k3a′/k3′ = 54 ± 10%. Negative activation energies are found at the higher level for the SH + Br2 and SH + BrCl (Br‐abstraction) reactions; as a result, the rate constants show a slightly negative temperature dependence, which is consistent with the determination in the literature. The kinetic isotope effects for the three reactions are “inverse”. The values of kH/kD are 0.88, 0.91, and 0.69 at room temperature, respectively, and they increase as the temperature increases. © 2004 Wiley Periodicals, Inc. J Comput Chem 26: 184–193, 2005
Hydrogels of Thermoreversible Comb‐Polymers Exhibit Increased Resistance for Dissolution
Authors: Jalil A. , Uludag H. 
Published: December 2004

AbstractThe N‐isopropylacrylamide (NiPAM) polymers exhibit thermoreversible properties in aqueous solutions. The resiliency of NiPAM hydrogels is believed to influence the outcome when the polymers are utilized in biomedical applications. To determine the influence of polymer architecture on hydrogel resiliency, polymers of NiPAM, methyl methacrylate (MMA) and acrylic acid were synthesized as random polymers and as comb polymers, where MMA was incorporated as side‐chains. Random polymers exhibited a Lower Critical Solution Temperature (LCST) that decreased in proportion to MMA content in polymers. The LCST of comb polymers was not dependent on MMA content or the length of MMA side‐chain (between 3.0 and 10.1 kD). Whereas low molecular weight (∼100 kD) random polymers did not form intact gels, comb‐polymers of equivalent molecular weight were capable of forming intact gels. Gel resiliency, as determined by propensity of hydrogels to dissolve upon cooling, was improved when the molecular weight of comb‐polymers was increased but the length of the MMA side‐branch did not influence the gel resiliency. We conclude that hydrogel dissolution was dependent on polymer architecture as well as the polymer molecular weight.
The Effect of the Stiffness of the stem of the Modular Revision Prosthesis MRP Titan Depending on Stem Diameter
Authors: Schuh A. , Holzwarth U. , Zeiler G. 
Published: December 2004

AbstractThe MRP‐Titan revision stem has proved to be a very successful implant system in revision arthroplasty of the hip joint. With this revision system good and very good clinical and excellent radiographic results with spontaneous filling out of femur defects were published in studies. The observation, that an atrophy of the proximal femur could be recorded with stem diameters above 17 mm, lead us to carry out stiffness measurements on different diameters of the MRP‐Titan revision stem.To determine the static bending characteristics, the bent 200 mm MRP‐Titan revision stem was tested under axial stress in accordance with Euler´s buckling cases. Various diameters from 13 to 22 mm were tested with a calibrated hydraulic MTS 810 axial piston testing machine (MTS Systems, Minneapolis, Minnesota, USA). Each test was carried out five times, the mean average value of the respective deflexion for each stem diameter was listed in a diagram. It turned out that deflexion decreased disproportionately from a stem diameter of > 18 mm. This correlated directly with an increased stiffness of the stem.With the MRP‐Titan revision stem a reliable implant in revision arthroplasty has been made available. The clinical observation of a proximal femur atrophy with stem diameters > 17 mm could be correlated in the series of experiments with a corresponding exponential increase in stiffness. The aim of continuing development will be to reduce the stiffness of the individual implant, especially in larger stem diameters, through constructive and/or material science measures.
Loss of Cx43 augments ATP‐mediated calcium signals of osteoblast‐like cells
Authors: Wiemann M. , Gramsch B. , Schirrmacher K. 
Published: December 2004

AbstractIntercellular communication of osteoblast‐like cells (OBL) is discussed to be a prerequisite for osseointegration of implants. This signaling involves changes of the intracellular calcium concentration ([Ca2+]i ) which can be elicited by mechanical stimuli and are propagated from cell to cell. These [Ca2+]i signals have originally been assumed to pass exclusively through gap junctions. However, substances such as purine nucleotides (ATP, UTP) are also released by osteoblasts upon mechanical stimulation and evoke [Ca2+]i signals in neighboring cells after binding to purine receptors. In this investigation we studied the impact of the major gap junction protein connexin 43 (Cx43) on ATP‐mediated calcium signaling of OBL in vitro. We compared OBL derived from calvaria of Cx43 deficient (Cx43‐/‐, Cx43+/–) and wild type animals (Cx43+/+). While application of ATP to Cx43+/+ or Cx43+/– OBL evoked a single transient increase of [Ca2+]i, the response of most Cx43‐/‐ OBL was pronounced in that the initial [Ca2+]i peak was larger and followed by 3‐10 repetitive calcium waves. With respect to shape and number of peaks different types of responses co‐existed in neighboring OBL, possibly pointing to differences in purinoceptor subtypes and/or filling states of intracellular calcium stores. Data show that ATP signaling of osteoblasts is changed in Cx43 deficient OBL, suggesting a compensatory role of purinoceptor mediated [Ca2+]i signaling secondary to an impaired gap junction communication in Cx43‐/‐ OBL.
Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease
Authors: Tsai Chon‐Haw , Chang Fang‐Chia , Lu Chin‐Song , Lee Shih‐Tseng , Huang Yu‐Ting , Lu Ming‐Kuei , Chen Rou‐Shayn , Wu Tony , Lee Jiann‐Der , Weng Yi‐Hsin , Chang Hsiu‐Chen 
Published: December 2004

AbstractSurgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico‐cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak‐to‐peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1‐msec to the 4‐msec delay points and the maximal inhibition was at the 3‐msec delay point (33.69% ± 6.50% of the control response). Mild facilitation was noticed since the 5‐msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3‐msec delay point (64.66 ± 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 ± 23.68% of the control at the 3‐msec delay point. The suppression was gone at and after the 7‐msec delay point. Results of repeated‐measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3‐msec delay point (P = 0.004). However, no correlation was observed between the 3‐msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD. © 2004 Movement Disorder Society
Risks and consequences of gene flow from herbicide‐resistant crops: canola (Brassica napus L) as a case study
Authors: Légère Anne 
Published: December 2004

AbstractData from the literature and recent experiments with herbicide‐resistant (HR) canola (Brassica napus L) repeatedly confirm that genes and transgenes will flow and hybrids will form if certain conditions are met. These include sympatry with a compatible relative (weedy, wild or crop), synchrony of flowering, successful fertilization and viable offspring. The chance of these events occurring is real; however, it is generally low and varies with species and circumstances. Plants of the same species (non‐transgenic or with a different HR transgene) in neighbouring fields may inherit the new HR gene, potentially generating plants with single and multiple HR. For canola, seed losses at harvest and secondary dormancy ensures the persistence over time of the HR trait(s) in the seed bank, and the potential presence of crop volunteers in subsequent crops. Although canola has many wild/weedy relatives, the risk of gene flow is quite low for most of these species, except with Brassica rapa L. Introgression of genes and transgenes in B rapa populations occurs with apparently little or no fitness costs. Consequences of HR canola gene flow for the agro‐ecosystem include contamination of seed lots, potentially more complex and costly control strategy, and limitations in cropping system design. Consequences for non‐agricultural habitats may be minor but appear largely undocumented. For the Department of Agriculture and Agri‐Food, Government of Canada, © Minister of Public Works and Government Services Canada 2005. Published for SCI by John Wiley & Sons, Ltd.
Many‐body energy decomposition analysis of cooperativity in hydrogen fluoride clusters
Authors: Rincón Luis , Almeida Rafael , García Aldea David 
Published: December 2004

AbstractThis article studies the cooperativity present in hydrogen fluoride clusters, (FH)n, by means of a many‐body decomposition of the binding energy. With the aim of quantifying how the results depend on the calculation level, the partition was performed from dimer to hexamer at the RHF, MP2, and density functional (B3LYP) levels, and for the heptamer and octamer at the RHF and B3LYP levels, using a 6‐31++G(d, p) basis set in all cases. We obtain that, for a proper representation of the cooperative effects in hydrogen fluoride, at least the inclusion of the three‐body terms is fundamental. The contributions are found to be underestimated at the RHF level and overestimated at the B3LYP level, with respect to the MP2 results. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2005
Study of metal ions (Na+, K+) interaction with different conformations of glycine molecule
Authors: Selvarengan P. , Kolandaivel P. 
Published: December 2004

AbstractInteraction of metal ions (Na+, K+) with different binding sites, such as amino nitrogen, hydroxyl oxygen, and carbonyl oxygen for all gaseous conformers of glycine molecule were investigated using Density Functional Theory (B3LYP/6‐311++G**, B3PW91/6‐311++G**) methods. It was found that the order of stability of the conformers was changed due to the binding of the metal ion. The relative energy values show that the 7p conformer is more stable than the 1p conformer when a metal ion binds with the carbonyl oxygen. The intensity of interaction on hydroxyl oxygen is very low due to the low basicity of hydroxyl oxygen. The binding affinities of the complexes were calculated using the thermochemical properties. The relative energy and chemical hardness values predicted the most stable complex. The calculated condensed Fukui functions predict the favorable reactive site among the three binding sites. It is concluded that the reactivity of each binding site varies for each conformation due to the presence of intramolecular hydrogen bonding. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2005
Density functional study of HO(H2O)n (n = 1–3) clusters
Authors: Dong Xiu‐Li , Zhou Zheng‐Yu , Tian Lai‐Jin , Zhao Gang 
Published: December 2004

AbstractThe hydrogen bonding complexes HO(H2O)n (n = 1–3) were completely investigated in the present study using DFT and MP2 methods at varied basis set levels from 6‐31++G(d,p) to 6‐311++G(2d,2p). For n = 1 two, for n = 2 two, and for n = 3 five reasonable geometries are considered. The optimized geometric parameters and interaction energies for various complexes at different levels are estimated. The infrared spectrum frequencies and IR intensities of the most stable structures are reported. Finally, thermochemistry studies are also carried out. The results indicate that the formation and the number of hydrogen bonding have played an important role in the structures and relative stabilities of different complexes. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2005
Conversion of unresectable to resectable hepatoblastoma and long‐term follow‐up study
Authors: Reynolds Marleta 
Published: December 2004

AbstractIn children with hepatoblastoma, cure or a prolonged diseasefree interval can only be accomplished with surgical resection of the primary tumor. Less than 50% of children with hepatoblastoma are felt to have resectable tumors at the time of diagnosis. Clinical studies have recently focused on the hypothesis that adjuvant chemotherapy can convert the unresectable tumor to a tumor that can be resected. Shortterm outcomes for patients treated with adjuvant chemotherapy and subsequent resection are nearly equal to those patients treated with initial resection followed by chemotherapy. This study is a review of the current literature on the chemotherapeutic conversion of unresectable hepatoblastoma and an update on the long‐term follow‐up of some of these patients.
Treatment of unresectable lung cancer with brachytherapy
Authors: Aygun Cengiz , Blum Julia E. 
Published: December 2004

AbstractEndobronchial brachytherapy is an evolving treatment modality. Although standard clinical indications and dosage schedules have not yet been established, the wide range of individual experience overwhelmingly demonstrates its efficacy in palliating lung cancer patients who generally have limited treatment options. Although the exact complication rate is not known, it appears to be low and the potential benefits far outweigh the risks. The role of endobronchial brachytherapy for cure is less clear. For most instances “prolonged palliation” would be a more suitable term than “cure.” Further data is needed to clarify the proper place of endobronchial brachytherapy as a boost to external beam radiation therapy. The dose, fractionation scheme and timing relative to external beam radiation therapy are based on institutional preference at this time. The historical evolution, treatment technique, results, and complications of endobronchial brachytherapy are reviewed here.
Comparison of different treatments for unresectable esophageal cancer
Authors: Reed Carolyn E. 
Published: December 2004

AbstractMany patients with esophageal cancer have advanced disease that is not amenable to curative treatment. For these individuals the relief of dysphagia is of utmost importance to the quality of their remaining survival time. This article reviews and compares the methods of palliation with focus on indications and contraindications, advantages as well as disadvantages of each technique, success rates, and complications. Tumor characteristics, the physician's experience, the institution's capabilities, cost, and patient preference will influence choice of palliation. Methods are often complementary rather than competitive.
Enhancement of biliary carcinogenesis in hamsters by cholecystokinin
Authors: Ikematsu Yoshito , Tomioka Tsutomu , Tajima Yoshitsugu , Tsunoda Tsukasa , Kanematsu Takashi 
Published: December 2004

AbstractWe recently developed a new model for rapid and reproducible induction of biliary carcinoma in hamsters. In the present study, we evaluated the effects of cholecystokinin (CCK), which has a trophic action on the gastrointestinal tract and on the pancreaticobiliary system, on biliary carcinogenesis in this hamster model. Hamsters treated with N‐nitrosobis (2‐oxopropyl) amine (BOP) were divided into four groups: In Group I, hydrolyzed gelatin, a solvent of CCK, was injected subcutaneously. In Groups II and III, CCK 2.5 and 25 μg/kg were administered, respectively. In Groups IV loxiglumide, a CCK receptor antagonist, was administered. CCK significantly promoted the carcinogenetic effect of GOP in the intra‐ and extrahepatic bile ducts but not in the gallbladder or pancreas. Loxiglumide exerted an inhibitory effect on carcinogenesis in the intrahepatic bile duct.