bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed duopoly in two‐sided markets
Authors: Kim Jeong‐Yoo 
Published: January 2024

AbstractThis paper considers a mixed duopoly two‐sided market of platforms in which a private firm competes with a public firm in a linear city model with fixed demand of full coverage. We examine whether prices of platforms are lower in the mixed duopoly market than in the standard pure duopoly market in which two private firms compete. We show that introducing a public competitor may or may not induce lower prices of the private platform than introducing a private firm, depending on the quality of the public platform service. In particular, if the quality of the public platform is superior, the prices of the platforms are lower than when it competes with the private rival, whereas they are higher if the quality is lower. We also show that the private firm invests more than the public firm. This has the policy implication that maintaining lower platform prices by introducing a competing public platform will not be sustainable in the long run.
Ancient tree genomes for old questions
Authors: Hipp Andrew L. , Lazic Desanka 
Published: January 2024

Most foundational work on the evolution and migration of plant species relies on genomic data from contemporary samples. Ancient plant samples can give us access to allele sequences and distributions on the landscape dating back to the mid Holocene or earlier (Gugerli et al., 2005). Nuclear DNA from ancient wood, however, has been mostly inaccessible until now. In a From the Cover article in this issue of Molecular Ecology, Wagner et al. (2023) present the first resequenced nuclear genomes from ancient oak wood, including two samples dated to the 15th century and one that dates to more than 3500 years ago. These ancient tree genomes open the possibility for investigating species adaptation, migration, divergence, and hybridisation in the deep past. They pave the way for what we hope will be a new era in the use of paleogenomics to study Holocene tree histories.
Hindu‐Christian Comparative Theology in a Decolonial Key
Authors: Voss Michelle 
Published: January 2024

AbstractThis article imagines how the discipline of comparative theology might sound in a decolonial key. Focusing on implications for Hindu‐Christian comparative theology, this article puts the sacramental theological approach of Indian Christian artist and theologian Jyoti Sahi into conversation with Michi Saagiig (Mississauga) Nishnaabeg theorist Leanne Betasamosake Simpson's notion of land as pedagogy. In contrast to the narrow epistemology that dominates the academy, this study highlights features of a land‐based alternative in which place, positionality, and relation are central to knowing; in which a subject is not first a thinker but a person in relation to a particular locale; and in which ecological and theological thinking encompass not only the sustainability of natural “resources,” but also the histories and exercises of power within a place.
Occupational fatigue, compassion competence and caring behaviours of intensive care nurses: A structural equation modelling approach
Authors: Sert Havva , Gulbahar Eren Merve , Ucgul Kübra 
Published: January 2024

AbstractBackgroundNo previous study has examined the direct effect of occupational fatigue, inter‐shift recovery and compassion competence on caring behaviours, including assurance, knowledge‐skill, respect and commitment in intensive care nurses.AimWe studied the direct effect of participating nurses' occupational fatigue, inter‐shift recovery and compassion competence levels on their caring behaviours and the relationship among these variables.Study DesignThis was a descriptive correlational study. All nurses who were registered members of the Turkish Intensive Care Nurses Association were invited to participate in this online survey. This study was conducted with 315 intensive care nurses using convenience sampling between April and July 2022. The data were collected using the Occupational Fatigue Exhaustion/Recovery Scale, which consists of three subscales: acute fatigue, chronic fatigue and inter‐shift recovery; the Compassion Competence Scale, including communication, sensitivity and insight subscales; and the Caring Behaviours Inventory‐24. In addition, a structural equation model was established using variables correlating with caring behaviours. Independent variables were occupational fatigue, inter‐ship recovery and compassion competence; and the dependent variable was caring behaviours in this hypothesized model.ResultsThree hundred and fifteen nurses completed the survey (315/1000) with a response rate of 31.5%. The increase in the inter‐shift recovery levels of participants was statistically and positively associated with caring behaviours (95% confidence interval [CI]: 0.001–0.011, β = .154 [moderate effect size], p < .05). The sub‐dimensions of the Compassion Competence Scale, that is, communication (95% CI: 0.110–0.443, β = .251 [moderate effect size]) and sensitivity (95% CI: 0.084–0.427, β = .241 [moderate effect size]), were statistically and positively associated with the caring behaviours of participants (p < .05). In addition, independent variables accounted for 35% (large effect size) of the total change in caring behaviours (R2 = 0.350).ConclusionsThis study suggests that the high inter‐shift recovery and compassion competence levels of intensive care nurses are positively associated with their caring behaviours.Relevance to Clinical PracticeNursing managers should consider the direct effect of occupational fatigue, inter‐shift recovery and the compassion competence levels of intensive care nurses on their caring behaviours to provide high‐quality care.
Deep learning‐based prediction of coronary artery calcium scoring in hemodialysis patients using radial artery calcification
Authors: Xu Yuankai , Li Wen , Yang Yanli , Dong Shiyi , Meng Fulei , Zhang Kaidi , Wang Yuhuan , Ruan Lin , Zhang Lihong 
Published: January 2024

AbstractObjectiveThis study used random forest model to explore the feasibility of radial artery calcification in prediction of coronary artery calcification in hemodialysis patients.Material and MethodsWe enrolled hemodialysis patients and performed ultrasound examinations on their radial arteries to evaluate the calcification status using a calcification index. All involved patients received coronary artery computed tomography scans to generate coronary artery calcification scores (CACS). Clinical variables were collected from all patients. We constructed both a random forest model and a logistic regression model to predict CACS. Logistic regression model was used to identify the risk factors of radial artery calcification.ResultsOne hundred eighteen patients were included in our analysis. In random forest model, the radial artery calcification index, age, serum C‐reactive protein, body mass index (BMI), diabetes, and hypertension history were related to CACS based on the average decrease of the Gini coefficient. The random forest model achieved a sensitivity of 76.9%, specificity of 75.0%, and area under receiver operating characteristic of 0.869, while the logistic regression model achieved a sensitivity of 75.2%, specificity of 68.7%, and area under receiver operating characteristic of 0.742 in prediction of CACS. Sex, BMI index, smoking history, hypertension history, diabetes history, and serum total calcium were all the risk factors related to radial artery calcification.ConclusionsA random forest model based on radial artery calcification could be used to predict CACS in hemodialysis patients, providing a potential method for rapid screening and prediction of coronary artery calcification.
Does digital government hollow out the essence of street‐level bureaucracy? A systematic literature review of how digital tools' foster curtailment, enablement and continuation of street‐level decision‐making
Authors: Marienfeldt Justine 
Published: January 2024

AbstractThe growing use of digital tools in policy implementation has altered the work of street‐level bureaucrats who are granted substantial discretionary power in decision‐making. Digital tools can constrain discretionary power, like the curtailment thesis proposed, or serve as action resources, like the enablement thesis suggested. This article assesses empirical evidence of the impact of digital tools on street‐level work and decision‐making in service‐oriented and regulation‐oriented organisations based on a systematic literature review and thematic qualitative content analysis of 36 empirical studies published until 2021. The findings demonstrate different effects with regard to the role of digital tools and the core tasks of the public administration, depending on political and managerial goals and consequent system design. Leading or decisive digital tools mostly curtail discretion, especially in service‐oriented organisations. In contrast, an enhanced information base or recommendations for actions enable decision‐making, in particular in regulation‐oriented organisations. By showing how street‐level bureaucrats actively try to resist the curtailing effects caused by rigid design to address individual circumstances, for instance by establishing ways of coping like rule bending or rule breaking, using personal resources or prioritising among clients, this study demonstrates the importance of the continuation thesis and the persistently crucial role of human judgement in policy implementation.
The heterogeneous impact of college education on happiness by gender
Authors: Jung Haeil , Gil Jung‐ah 
Published: January 2024

AbstractObjectiveThis study examines the heterogeneous impacts of college education on happiness by gender.MethodsTo yield unbiased impact estimates, we take advantage of a natural experiment known as the graduation quota program, which suddenly and massively expanded the opportunities to attend college in the early 1980s in South Korea. Using whether the birth cohorts were exposed to the graduation quota program as an instrumental variable (IV), this study estimates the longer‐term effects of college education on happiness by gender.ResultsThe estimated local average treatment effect by the IV analysis indicates that men who were induced to attend college by the graduation quota program became happier. However, there was no noticeable impact on women's happiness.ConclusionsConsidering that the subjective happiness in our study was measured in their late 30s and 40s, the impact of college on happiness seems to be long‐lasting for men but not for women.
Five‐year single‐center analysis of cytomegalovirus viremia in kidney transplant recipients and possible implication for novel prophylactic therapy approaches
Authors: Trappe Moritz , Affeldt Patrick , Grundmann Franziska , Kann Martin , Koehler Felix C. , Müller Roman‐Ulrich , Stippel Dirk , Kaiser Rolf , Knops Elena , Heger Eva , Steger Gertrud , Klein Florian , Kurschat Christine , Di Cristanziano Veronica 
Published: January 2024

AbstractBackgroundCytomegalovirus (CMV) infections are a common complication after kidney transplantation (KTx) and negatively affecting patient outcome. Valganciclovir (VGC) prophylaxis is often limited by drug‐induced side effects and dose reduction due to decline in kidney function.MethodIn the present study, episodes of CMV viremia in the first year after KTx in a cohort of 316 recipients were analyzed retrospectively to identify risk factors linked to persistent infections.ResultsIn the studied cohort, 18.7% of patients showed a high‐risk (HR) constellation (D+/R–) for CMV infections. CMV viremia affected 22% of our cohort, with HR patients being the most affected cohort (44.1%). Within this group, most viremic events (65.3%) occurred while patients were still on prophylactic therapy, showing significantly higher viral loads and a longer duration compared to seropositive recipients.ConclusionThe analysis at hand revealed that detection of viremia under ongoing antiviral prophylaxis bears an increased risk for sustained viral replication and antiviral drug resistance in HR patients. We identified low estimated glomerular filtration rate (eGFR) and lower dose VGC prophylaxis post‐KTx as a risk factor for breakthrough infections in HR patients in our single center cohort. These patients might benefit from a closer CMV monitoring or novel prophylactic agents as letermovir.
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Haplotype‐resolved genome assembly of Phanera championii reveals molecular mechanisms of flavonoid synthesis and adaptive evolution
Authors: Lu Yongbin , Chen Xiao , Yu Hang , Zhang Chao , Xue Yajie , Zhang Qiang , Wang Haifeng 
Published: January 2024

SUMMARYPhanera championii is a medicinal liana plant that has successfully adapted to hostile karst habitats. Despite extensive research on its medicinal components and pharmacological effects, the molecular mechanisms underlying the biosynthesis of critical flavonoids and its adaptation to karst habitats remain elusive. In this study, we performed high‐coverage PacBio and Hi‐C sequencing of P. championii, which revealed its high heterozygosity and phased the genome into two haplotypes: Hap1 (384.60 Mb) and Hap2 (383.70 Mb), encompassing a total of 58 612 annotated genes. Comparative genomes analysis revealed that P. championii experienced two whole‐genome duplications (WGDs), with approximately 59.59% of genes originating from WGD events, thereby providing a valuable genetic resource for P. championii. Moreover, we identified a total of 112 genes that were strongly positively selected. Additionally, about 81.60 Mb of structural variations between the two haplotypes. The allele‐specific expression patterns suggested that the dominant effect of P. championii was the elimination of deleterious mutations and the promotion of beneficial mutations to enhance fitness. Moreover, our transcriptome and metabolome analysis revealed alleles in different tissues or different haplotypes collectively regulate the synthesis of flavonoid metabolites. In summary, our comprehensive study highlights the significance of genomic and morphological adaptation in the successful adaptation of P. championii to karst habitats. The high‐quality phased genomes obtained in this study serve as invaluable genomic resources for various applications, including germplasm conservation, breeding, evolutionary studies, and elucidation of pathways governing key biological traits of P. championii.
Healthcare center‐based cell therapy laboratories supporting off‐site manufactured cell therapies: The experiences of a single academic cell therapy laboratory
Authors: Dinh Anh , Stroncek David F. 
Published: January 2024

AbstractBackgroundHealthcare center‐based cell therapy laboratories (HC CTLs) evolved from solely processing hematopoietic stem cells for transplantation to manufacturing various advanced cellular therapies. With increasing interest in cellular therapy applications, off‐site manufactured products are becoming more common. HC CTLs play a critical role in supporting these products by shipping out cellular starting material (CSM) for further manufacturing and/or receiving, storing, and distributing final products. The experiences and challenges encountered by a single academic HC CTL in supporting these products are presented.MethodsAll off‐site manufacturing protocols supported before 2023 were reviewed. Collected data included protocol characteristics (treatment indication, product type), process logistics (shipping, receiving, storage, thawing, distribution, documentation), and product handling volumes (CSM shipping and final product infusions).ResultsBetween 2012 and 2022, 15 off‐site manufactured cellular therapy early‐phase, single‐ and multicenter clinical trials were supported. Trials were sponsored by academic/research and commercial entities. The number of protocols supported annually increased each year, with few ending. Products included cancer immunotherapies and gene therapies. Autologous CSM was collected and shipped, while autologous and allogeneic final products were received, stored, thawed, and distributed. Process differences among protocols included CSM shipping conditions, laboratory analyses, final product thaw conditions and procedures, number of treatments, and documentation.DiscussionHC CTLs must contend with several challenges in supporting off‐site manufacturing protocols. As demand for cellular therapies increases, stakeholders should collaborate from the early phases of clinical trials to streamline processes and standardize procedures to increase value, improve safety, and reduce the burden on HC CTLs.
Sustained delirium reduction in an inpatient neuroscience unit
Authors: Kozub Elizabeth , Hedquist Katie , Tu Lisa , Bryant Ruth 
Published: January 2024

AbstractBackgroundDelirium is described as acute brain dysfunction that often fluctuates throughout the day and is highly prevalent in hospitalized adults. Delirium negatively affects patient outcomes with consequences including decreased cognitive functioning and increased mortality and healthcare costs. Furthermore, neurological patients are at increased risk for developing delirium due to their underlying diagnoses.PurposeThe purpose of this evidence‐based practice project was to evaluate the long‐term impact of nursing education and use of trained volunteers to prevent the development of delirium in an inpatient neuroscience unit.Implementation PlanThis was a pre–post designed evidence‐based practice project to educate and prioritize nursing care interventions for delirium prevention compared to a delirium management framework. The interventions included delirium education for nurses and nursing assistants along with the development of a specialized volunteer program to implement non‐pharmacological, multi‐component delirium prevention interventions. Long‐term sustainment and enculturation occurred over the subsequent year.OutcomesThe baseline data collection period included 2520 patients. The intervention period included 4515 patients, with both groups being similar in age, race, gender, and length of stay. The total number of patients with a discharge diagnosis of delirium decreased from 29.2% to 19.8% (p < .001). Fewer patients in the intervention group were discharged to a skilled nursing facility (p < .001) and other post‐acute facility (p = .008), along with more patients being discharged to home care (p < .001).Linking Evidence to ActionThis evidence‐based practice project demonstrates long‐term sustained reduction of delirium in the neuroscience population. Despite the challenges during the COVID‐19 pandemic, delirium prevention strategies were found to be effective in decreasing the rate at which patients develop delirium.
Derived equivalences of self‐injective 2‐Calabi–Yau tilted algebras
Authors: Kortegaard Anders S. 
Published: January 2024

AbstractConsider a ‐linear Frobenius category such that the corresponding stable category is 2‐Calabi–Yau, Hom‐finite with split idempotents. Let be maximal rigid objects with self‐injective endomorphism algebras. We will show that their endomorphism algebras and are derived equivalent. Furthermore, we will give a description of the two‐sided tilting complex that induces this derived equivalence.
Alterations in neuromuscular junction morphology with ageing and endurance training modulate neuromuscular transmission and myofibre composition
Authors: Yamaguchi Tatsuhiro , Kouzaki Karina , Sasaki Kazushige , Nakazato Koichi 
Published: January 2024

AbstractBoth ageing and exercise training affect the neuromuscular junction (NMJ) structure. Morphological alterations in the NMJ have been considered to influence neuromuscular transmission and myofibre properties, but the direct link between the morphology and function has yet to be established. We measured the neuromuscular transmission, myofibre composition and NMJ structure of 5‐month‐old (young) and 24‐month‐old untrained (aged control) and trained (aged trained) mice. Aged trained mice were subjected to 2 months of endurance training before the measurement. Neuromuscular transmission was evaluated in vivo as the ratio of ankle plantar flexion torque evoked by the sciatic nerve stimulation to that by direct muscle stimulation. The torque ratio was significantly lower in aged mice than in young and aged trained mice at high‐frequency stimulations, showing a significant positive correlation with voluntary grip strength. The degree of pre‐ to post‐synaptic overlap of the NMJ was also significantly lower in aged mice and positively correlated with the torque ratio. We also found that the proportion of fast‐twitch fibres in the soleus muscle decreased with age, and that age‐related denervation occurred preferentially in fast‐twitch fibres. Age‐related denervation and a shift in myofibre composition were partially prevented by endurance training. These results suggest that age‐related deterioration of the NMJ structure impairs neuromuscular transmission and alters myofibre composition, but these alterations can be prevented by structural amelioration of NMJ with endurance training. Our findings highlight the importance of the NMJ as a major determinant of age‐related deterioration of skeletal muscles and the clinical significance of endurance training as a countermeasure.
imageKey points
The neuromuscular junction (NMJ) plays an essential role in neuromuscular transmission and the maintenance of myofibre properties.
We show that neuromuscular transmission is impaired with ageing but recovered by endurance training, which contributes to alterations in voluntary strength.
Neuromuscular transmission is associated with the degree of pre‐ to post‐synaptic overlap of the NMJ.
Age‐related denervation of fast‐twitch fibres and a shift in myofibre composition toward a slower phenotype are partially prevented by endurance training.
Our study provides substantial evidence that age‐related and exercise‐induced alterations in neuromuscular transmission and myofibre properties are associated with morphological changes in the NMJ.
Numerical Study on the Effects of Re on the Unsteady Behaviors in a Transonic Axial-Fan Under Inlet Distortion
Authors: Li Zhiping , Zhu Xingyu , Yan Zhaoqi , Pan Tianyu 
Published: January 2024

Abstract
The dynamic response of a compression system is the complex dynamic behaviors reacted by the compressor subject to non-uniform inflow excitation. However, in a real operating condition, the compressor would work at a wide range of altitudes within the flight envelope, which forces us to consider how Re additionally affects the compressor performance loss and dynamic response characteristic due to inlet distortion. To explore this issue, a full-annulus unsteady 3D simulation has been used to calculate the performance of a transonic axial fan with a 180-deg distortion at different Re. The results show that Re has additional detrimental effects on the fan aerodynamic performance with non-uniform inflow. To further explore the mechanisms of Re effects on fan–distortion interaction, the spatial and temporal distribution of the rotor blade response is discussed. The temporal distribution of the fan–distortion interaction is not changed with Re by analyzing the dynamic response orbit of the fan rotor. However, the spatial distribution of Re effects is highly related to the blade profile loaded mode at different spanwise locations. The results indicate that the time constant of fan dynamic response decreases by 17% at the mid-loaded region in the middle of the blade and increases by 40% at the aft-loaded region near the blade tip. Further analysis reveals that due to the low Re and flow separation of the suction surface, the thickness variation of blade boundary layer is the main cause for varying the blade time constant.