bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient health-related quality of life deteriorates significantly while waiting six to 12 months for total hip or knee arthroplasty
Authors: Scott Chloe E. H. , Yapp Liam Z. , MacDonald Deborah J. , Howie Colin R. , Clement Nick D. 
Published: February 2024

AimsThe primary aim was to assess change in health-related quality of life (HRQoL) of patients as they waited from six to 12 months for a total hip (THA) or total or partial knee arthroplasty (KA). Secondary aims were to assess change in joint-specific function, mental health, quality of sleep, number living in a state worse than death (WTD), wellbeing, and patient satisfaction with their healthcare.MethodsThis prospective study included 142 patients awaiting a THA (mean age 66.7 years (SD 11.4); 71 female) and 214 patients awaiting KA (mean age 69.7 years (SD 8.7); 117 female). Patients completed questionnaires (EuroQol five-dimension health questionnaire (EQ-5D), Oxford Hip and Knee Scores (OHS/OKS), Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Score (HADS), University of California, Los Angeles Activity Scale, wellbeing assessment, and satisfaction with their healthcare) at six and 12 months while awaiting surgery.ResultsThere was a clinical and statistically significant deterioration in the EQ-5D while awaiting THA (mean change 0.071 (95% confidence interval (CI) 0.018 to 0.124); p = 0.009) and KA (mean change 0.069 (95% CI 0.032 to 0.106); p < 0.001). For patients awaiting a THA, there were deteriorations in OHS (p = 0.003), PSQI (p = 0.008), both HADS depression (p = 0.001) and anxiety (p = 0.002), and an increased prevalence in those in a state WTD (p = 0.010). For those awaiting KA, there were significant deteriorations in OKS (p < 0.001), UCLA (p = 0.001), and HADS depression (p < 0.001) and anxiety (p < 0.001). There were significant decreases in wellbeing (satisfaction with life, feeling life to be worthwhile, and happiness) and increases in anxiety for those awaiting THA or KA (p < 0.001). Those awaiting THA (odds ratio (OR) 0.52 (95% CI 0.31 to 0.89); p = 0.016) and KA (OR 0.46 (95% CI 0.31 to 0.71); p < 0.001) had a significant decrease in satisfaction with their healthcare.ConclusionAs patients waited from six to 12 months for THA or KA, they experienced a clinically significant deterioration in HRQoL. There were also deteriorations in joint-specific function, mental health, wellbeing, and patient satisfaction with healthcare.Cite this article: Bone Joint J 2024;106-B(2):166–173.
Effect of antiplatelet therapy after COVID-19 diagnosis: A systematic review with meta-analysis and trial sequential analysis
Authors: Duo Hong , Jin Mengying , Yang Yanwei , Baheti Rewaan , Feng Yujia , Fu Zirui , Jiang Yuyue , Zheng Lanzhuoying , Wan Jing , Pan Huaqin 
Published: February 2024

Background
Coronavirus disease 2019 (COVID-19) may predispose patients to thrombotic disease in the venous and arterial circulations.

Methods
Based on the current debate on antiplatelet therapy in COVID-19 patients, we performed a systematic review and meta-analysis to investigate the effect of antiplatelet treatments. We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science on February 1, 2023, and only included Randomized clinical trials. The study followed PRISMA guidelines and used Random-effects models to estimate the pooled percentage and its 95% CI.

Results
Five unique eligible studies were included, covering 17,950 patients with COVID-19. The result showed no statistically significant difference in the relative risk of all-cause death in antiplatelet therapy versus non-antiplatelet therapy (RR 0.94, 95% CI, 0.83–1.05, P = 0.26, I2 = 32%). Compared to no antiplatelet therapy, patients who received antiplatelet therapy had a significantly increased relative risk of major bleeding (RR 1.81, 95%CI 1.09–3.00, P = 0.02, I2 = 16%). The sequential analysis suggests that more RCTs are needed to draw more accurate conclusions. This systematic review and meta-analysis revealed that the use of antiplatelet agents exhibited no significant benefit on all-cause death, and the upper bound of the confidence interval on all-cause death (RR 95% CI, 0.83–1.05) suggested that it was unlikely to be a substantiated harm risk associated with this treatment. However, evidence from all RCTs suggested a high risk of major bleeding in antiplatelet agent treatments.

Conclusion
According to the results of our sequential analysis, there is not enough evidence available to support or negate the use of antiplatelet agents in COVID-19 cases. The results of ongoing and future well-designed, large, randomized clinical trials are needed.
Video-flujo-foto (resina)
Authors: Billelabeitia Bengoa Iñaki 
Published: February 2024

Entre el llamado 'cine de exposición' y el videoarte, término que se asocia a cierta condición pretérita, parecen hallar su lugar unas formas de videocreación que provisionalmente podemos designar como 'video de exposición'. En este sentido nos interesa atender al tratamiento de la temporalidad y a la ruptura del flujo normativo que el cine y el audiovisual contemporáneo contemplan a partir de una renovada tendencia a la estaticidad de la imagen. El recurso a la imagen deformada en el flujo temporal por ralentización, estasis o tomas largas contemplativas, establecen prácticas disruptivas que propician lo que Bellour calificó como 'efecto de pensatividad' -y que Barthes o Deleuze ya habían sugerido-. El texto aborda esta condición reflexiva considerando la dialéctica ocurrida a partir del giro del cine y el video hacia lo fotográfico y que ya fuera precedido de un proceso de audiovisualización de la propia imagen fotográfica. El encuentro entre el videoflujo y la fotografía-flujo configura así un área de tiempo y duración donde acontecen las formas postnarrativas contemporáneas propias del espacio expositivo. El encuentro entre vídeo-flujo y fotografía-flujo configura así un área de tiempo y duración donde acontecen las formas postnarrativas características del espacio expositivo contemporáneo.
Assessment of the Energy System of Ukraine: Ways of Recovery, Cases of Development
Authors: Osadcha Natalia , Zaverbnyj Andrij 
Published: February 2024

The economy of Ukraine is partially destroyed and poses an energy threat to European countries. The article analyzes trends in the development of consumption in Ukraine, and assesses the prospects for development. Energy Ukraine's system depends on fossil fuels. The government sought to diversify risks and ensure sustainable development. The energy consumption market is characterized by a decline and an increase in the use of gas.
The article develops cases for making decisions on the necessary investments in the energy system of Ukraine after the war. We analyze energy consumption trends and justify the need for investment in the nuclear industry, which occupies a large part of the country's energy consumption. A model for assessing and forecasting the energy consumption market has been developed. The model shows an upward trend in oil and gas consumption. Our approach allows us to quantify the net increase in energy consumption in the future.
Keywords: energy, energy supply, renewable energy, energy strategy, energy resources
Theories of Migration: Sociological and Conceptual Dilemmas
Authors: Al-Khudairy Saleh I.A. 
Published: February 2024

The aim of this study is to introduce to the researchers' migration theories in a brief and modern form. As rates of migration are increasing all over the world for different reasons it became necessary to review critically the theories that dealt with such important social phenomenon. The study is an analytical and critical study adopted the documentary research methodology and the office work and content analysis as a tool to obtain information. The study discussed many aspects of sociological theories such as definitions, typologies, areas of strength and weakness and historical development In this study theories of migration were classified into three main types: macro level theories, micro level theories, and the ones, which attempts to bridge the gap between these levels.
Keywords: Migration, Migration theories, Macro Theories, Micro Theories, Typology
Low-Dose Aspirin and Prevention of Colorectal Cancer: Evidence From a Nationwide Registry-Based Cohort in Norway
Authors: Nafisi Sara , Støer Nathalie C. , Veierød Marit B. , Randel Kristin R. , Hoff Geir , Löfling Lukas , Bosetti Cristina , Botteri Edoardo 
Published: February 2024

INTRODUCTION:
To examine the association between low-dose aspirin use and risk of colorectal cancer (CRC).

METHODS:
In this nationwide cohort study, we identified individuals aged 50 years or older residing for 6 months or more in Norway in 2004–2018 and obtained data from national registers on drug prescriptions, cancer occurrence, and sociodemographic factors. Multivariable Cox regression models were used to estimate the association between low-dose aspirin use and CRC risk. In addition, we calculated the number of CRC potentially averted by low-dose aspirin use.

RESULTS:
We included 2,186,390 individuals. During the median follow-up of 10.9 years, 579,196 (26.5%) used low-dose aspirin, and 38,577 (1.8%) were diagnosed with CRC. Current use of aspirin vs never use was associated with lower CRC risk (hazard ratio [HR] 0.87, 95% confidence interval [CI] 0.84–0.90). The association was more pronounced for metastatic CRC (HR 0.79; 95% CI 0.74–0.84) than regionally advanced (HR 0.89; 95% CI 0.85–0.92) and localized CRC (HR 0.93; 95% CI 0.87–1.00; P heterogeneity = 0.001). A significant trend was found between duration of current use and CRC risk: HR 0.91 (95% CI 0.86–0.95) for <3 years, HR 0.85 (0.80–0.91) for ≥3 and <5 years, and HR 0.84 (0.80–0.88) for ≥5 years of use vs never use (P trend < 0.001). For past use, HR were 0.89 (95% CI 0.84–0.94) for <3 years, 0.90 (0.83–0.99) for ≥3 and <5 years, and 0.98 (0.91–1.06) for ≥5 years since last use vs never use (P-trend < 0.001). We estimated that aspirin use averted 1,073 cases of CRC (95% CI 818–1,338) in the study period.

DISCUSSION:
In this nationwide cohort, use of low-dose aspirin was associated with a lower risk of CRC.
Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training
Authors: Koltun Kristen J. , Sterczala Adam J. , Sekel Nicole M. , Krajewski Kellen T. , Martin Brian J. , Lovalekar Mita , Connaboy Christopher , Flanagan Shawn D. , Wardle Sophie L. , O'Leary Thomas J. , Greeves Julie P. , Nindl Bradley C. 
Published: February 2024

AbstractWeight‐bearing physical activity can stimulate bone adaptation. This investigation explored the effect of an acute bout of resistance exercise before and after resistance+interval training on circulating biomarkers of bone metabolism and muscle‐bone crosstalk. Healthy young male and female participants (n = 21 male, 28 ± 4 years; n = 17 female, 27 ± 5 years) performed a 6 × 10 squat test (75% 1RM) before and after a 12‐week resistance+interval training program. Before and after completion of the training program, blood samples were collected at rest, immediately postexercise, and 2 h postexercise. Blood samples were analyzed for βCTX, P1NP, sclerostin, osteocalcin, IGF‐1, and irisin. Significant effects of acute exercise (main effect of time) were observed as increases in concentrations of IGF‐1, irisin, osteocalcin, and P1NP from rest to postexercise. A sex*time interaction indicated a greater decline in βCTX concentration from rest to 2 h postexercise and a greater increase in sclerostin concentration from rest to immediately postexercise in male compared with female participants. Sex differences (main effect of sex) were also observed for irisin and P1NP concentrations. In summary, changes in concentrations of biochemical markers of bone metabolism and muscle‐bone crosstalk were observed in males and females after an acute bout of resistance exercise and following 12 weeks of resistance+interval training.
Evaluation of ventricular–vascular coupling with critical care metrics: An in silico approach
Authors: Mulligan Lawrence J. , Ungerleider Justin , Friedman Adam , Sanders Benjamin , Thrash Julian , Ewert Daniel , Mitrev Ludmil , Hill Jeffrey C. 
Published: February 2024

AbstractMean arterial pressure and cardiac output provide insufficient guidance for the management of intraoperative hypotension (IOH). In silico models offer additional insights into acute changes in hemodynamic parameters that may be encountered during IOH. A computational model (CM) generated parameters quantifying ventricular–vascular coupling, and pressure–volume construct across levels of aortic compliance (CA). We studied how a loss from normal‐to‐stiff CA impacts critical care metrics of hemodynamics during vascular occlusion. Pulse pressure (PP), end‐systolic pressure (Pes), arterial compliance (Art‐ca), arterial elastance (Art‐ea), and dynamic arterial elastance (Eadyn), along mechanical efficiency (ME) were measured at five levels of CA. A loss in CA impacted all variables. During steady‐state conditions, PP, Pes, and stroke work increased significantly as CA decreased. Art‐ca decreased and Art‐ea increased similarly; Eadyn increased and ME decreased. During a decrease in preload across all CA levels, arterial dynamics measures remained linear. The CM demonstrated that a loss in CA impacts measures of arterial dynamics during steady‐state and transient conditions and the model demonstrates that critical care metrics are sensitive to changes in CA. While Art‐ca and Art‐ea were sensitive to changes in preload, Eadyn did not change.
Static magnetic field stimulation enhances shunting inhibition via a SLC26 family Cl−channel, inducing intrinsic plasticity
Authors: Sinha Adya saran , Shibata Sumiya , Takamatsu Yasuyuki , Akita Tenpei , Fukuda Atsuo , Mima Tatsuya 
Published: February 2024

Magnetic fields are being used for detailed anatomical and functional examination of the human brain. In addition, evidences for their efficacy in treatment of brain dysfunctions is accumulating. Transcranial static magnetic field stimulation (tSMS) is a recently developed technique for non-invasively modifying brain functions. In tSMS, a strong and small magnet when placed over the skull can temporarily suppress brain functions. Its modulatory effects persist beyond the time of stimulation. However, the neurophysiological mechanisms underlying tSMS-induced plasticity remain unclear. Here, using acute motor cortical slice preparation obtained from male C57BL/6N mice, we show that tSMS alters the intrinsic electrical properties of neurons by altering the activity of chloride (Cl−) channels in neurons. Exposure of mouse pyramidal neurons to a static magnetic field (SMF) at a strength similar to human tSMS, temporarily decreased their excitability and induced transient neuronal swelling. The effects of SMF were blocked by DIDS and GlyH-101, but not by NPPB, consistent with the pharmacological profile of SLC26A11, a transporter protein with Cl−channel activity. Whole-cell voltage-clamp recordings of the GlyH-101-sensitive Cl−current component showed significant enhancement of the component at both subthreshold and depolarized membrane potentials after SMF application, resulting in shunting inhibition and reduced repetitive action potential (AP) firing at the respective potentials. Thus, this study provides the first neurophysiological evidence for the inhibitory effect of tSMS on neuronal activity and advances our mechanistic understanding of non-invasive human neuromodulation.Significance StatementTranscranial static magnetic field stimulation (tSMS) is a recently developed non-invasive brain stimulation technique. In tSMS, a strong, small magnet placed over the skull temporarily suppresses brain functions, and its modulatory effects persist beyond the stimulation time. To elucidate the neurophysiological mechanisms of tSMS, we evaluated the excitability of mouse pyramidal neurons exposed to a static magnetic field at a strength similar to that of human tSMS using whole-cell patch-clamp experiments. We demonstrated that the static magnetic field temporarily decreased neuronal excitability by increasing the activity of a specific type of Cl−channel in the plasma membrane, and it also induced transient neuronal swelling. This study reveals for the first time the neurophysiological mechanism of tSMS-induced suppression of brain functions.
NATURE OF ECONOMIC SANCTIONS AND REASONS FOR THEIR APPLICATION
Authors: ZVERIEV Oleh 
Published: February 2024

Economic sanctions are an important tool of international policy aimed at influencing countries that violate international standards or pursue aggressive policy. The essence of economic sanctions is to restrict trade, financial transactions, and investments to stimulate changes in political or economic behavior of the target country. Grounds for the application of economic sanctions may include human rights violations, annexation of territories, military aggression or other actions that contradict international norms. The international community bodies, such as the UN or the European Union, make decisions on the application of sanctions based on a joint assessment of the situation and the desire to preserve world peace and stability. The effectiveness of economic sanctions is a matter of debate, sometimes they can lead to changes in the country's policy, and sometimes they cause suffering to the population. Within the community of nations, it is important to balance the strategies of sanctions and diplomacy to achieve the desired results while maximizing the positive impact on the geopolitical situation.
At the stage of searching for widely acceptable agreements in global trade and economic relations, mutual consideration of interests becomes especially important. In modern conditions, these spheres have become the object of unprecedented politicization. Considerable attention is paid to the values of free trade, which nowadays often become hostages of trade conflicts and unfair competition. Recently, sanctions have gained an important role in international economic relations. Motives for applying sanctions, including economic ones, can be diverse and depend on various factors, the main of which are political considerations. In most cases, economic sanctions are determined by political goals that are accomplished through economic pressure.
The very term "sanctions" and their mechanism in the international sphere combine regulatory, political, and economic aspects, forming the interdisciplinary nature of this phenomenon in theoretical terms.
ВИКОРИСТАННЯ ШТУЧНОГО ІНТЕЛЕКТУ В ПРОЦЕСАХ СТРАТЕГІЧНОГО УПРАВЛІННЯ ПІДПРИЄМСТВАМИ
Authors: ТАРАНИЧ Андрій , ПЕЛЕХАЦЬКИЙ Дмитро 
Published: February 2024

Досліджено тенденції розвитку і можливості використання штучного інтелекту в процесі стратегічного управління компанією в кризових умовах для стабілізації і збереження конкурентоспроможності бізнесу. Проаналізовано сфери застосування і місце штучного інтелекту в управлінні бізнес-процесами, вплив інновацій, що використовують машинне навчання, на стратегічній аспект діяльності компанії для формування рекомендацій щодо забезпечення конкурентних переваг і оптимізації використання обмежених ресурсів.
На основі проведеного аналізу доведено позитивний вплив упровадження інновацій на рентабельність бізнесу. Визначено основні переваги технологій на основі штучного інтелекту і драйвери їх розвитку. Розглянуто використання штучного інтелекту для предикативного аналізу з метою подальшого використання результатів у стратегічному управлінні й реалізації діяльності компанії. Проаналізовано можливості штучного інтелекту щодо оптимізації діяльності фахівців сфери маркетингу й управління. Визначено можливості дослідження конкурентних ринків і поведінкових аспектів клієнтів компанії за допомогою штучного інтелекту на основі Big Data, описано синергію технології з сучасними CRM-системами. Окреслено переваги використання штучного інтелекту при розширенні діяльності компанії завдяки можливостям технологій на основі штучного інтелекту і машинного навчання забезпечувати високо персоналізований позитивний клієнтський досвід взаємодії з компанією, навіть у мінливих умовах.
Особливу увагу приділено основним способам використання штучного інтелекту при реалізації бізнес-моделі підприємства в кризових умовах. Проаналізовано процеси і принципи інтеграції штучного інтелекту в діяльність підприємства, визначено показники якості даних для мінімізації ризиків упровадження інновацій і умови ефективного використання даних технологій з метою формування конкурентних переваг, які дозволять швидко адаптуватися при негативному впливі зовнішнього середовища на сформовані бізнес-процеси.
Las Oportunidades del Cannabis Medicinal Colombiano en el Mercado Asiático y Europeo
Authors: Laura Marcela Maldonado Agudelo  , María Alejandra Ospino Tirado  , María Paula Alzate Jiménez  
Published: February 2024

El objetivo es conocer los beneficios del Cannabis medicinal colombiano y las oportunidades de mercado a través de la exportación a Europa y Asia; Colombia puede crear un mercado representativo con el cannabis medicinal ya que este es un producto con valor agregado que ayudaría a diversificar la oferta exportable del país y a darle mayor dinamismo a la economía.
La metodología utilizada fue descriptiva de corte cualitativo, se utilizaron fuentes secundarias para la recolección de la información que posteriormente fue analizada y procesada para establecer comparativos y llegar a las conclusiones.
En los resultados se encontró que con el Decreto 811 de 2021 el marco legal colombiano abre las puertas para la comercialización del Cannabis Medicinal a nivel internacional; igualmente, se evidenciaron que paises como Holanda, Uruguay y Malta, se proyectan como mercados atractivos para las empresas colombianas de esta industria debido a su marco legal aceptable para el Cannabis medicinal y recreativo. Los paises asiáticos dada su poca apertura legal, no se muestran como atractivos para la internacionalización del Cannabis medicinal.
“Migrants are citizens too!”: Everyday acts of citizenship and the lived experiences of Venezuelans across the Andes
Authors: Palma-Gutiérrez Mauricio 
Published: February 2024

Abstract
Amid one of the largest ongoing cross-border migration processes in the world, Venezuelans living across the Andes are often categorized as non-citizens by the governments of the countries they reside in. Full access to their rights is limited by dominant legal technologies of population governance, centered on positioning individuals as subjects in/of nation-states, under different political /juridical statuses instrumental to consolidate objectives of ‘migration management’. Yet, by embracing diverse, and meaningful acts of citizenship, many have found creative ways to perform citizenship in countries such as Colombia, Ecuador, Peru, and Chile; allowing them access to some rights that otherwise could not be effectively claimed. In this article, I use 23 interviews with migration activists in these four countries to explore the formation of a specific form of political subjectivity in the case of Venezuelans, through the dual lens of acts of citizenship and of performative citizenship. I argue that in absence of an equivalent legal status, quotidian actions derived from different productive and creative acts are essential in enabling a disruptive form of lived citizenship across an alternative, evolving space for politics in the Andean region.