bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE USE OF TRANEXAMIC ACID MOUTHWASH IN THE GINGIVAL BLEEDING MANAGEMENT IN APLASTIC ANEMIA PATIENT
Authors: BAKTI FITRAH UTARI , FITRIASARI NURI , WAHYUNI INDAH SUASANI 
Published: December 2023

Objective: The aim of this study was to describe the role of tranexamic acid mouthwash in the management of gingival bleeding in aplastic anemia patients.
Methods: Complete subjective, objective, and supporting examinations were carried out to confirm the diagnosis. Treatments were given in collaboration between the departments of internal and oral medicine. Anamnesis and history taking were done, and it was revealed that a 21-year-old male patient came with the chief complaint of active anterior mandible gum bleeding, starting two weeks ago and accompanied by fever. Extra-oral examination revealed a hematoma on the lip. Intra-oral examination found spontaneous bleeding from the anterior mandible gingiva and hematomas on the labial mucosa and lateral of the tongue. Laboratory examination results showed hemoglobin, hematocrit, erythrocytes, leukocytes, and platelets below the normal range, and the bone marrow morphology examination confirmed the diagnosis of aplastic anemia.
Results: Treatment included a blood transfusion of 39 flasks for 14 d for the systemic condition. Tranexamic acid and chlorine dioxide mouthwash were given for intra-oral problems, and petroleum jelly to treat lip lesions. Gingival bleeding and hematomas resolved within 8 d.
Conclusion: Tranexamic acid mouthwash, along with manual scaling of calculus, which is a predisposing factor for gingival bleeding, as well as blood transfusion, have an important role in the successful comprehensive management of gingival bleeding due to pancytopenia in patients with aplastic anemia.
PROTEIN-PROTEIN INTERACTION ANALYSIS TO IDENTIFY NUCLEAR FACTOR-ERYTHROID-2 FACTOR 2 (NRF2) INHIBITION BY EXTRACELLULAR ENZYMES FROM WATER KEFIR ORGANISMS
Authors: ALIGITA WIDHYA , SINGGIH MARLIA , SUTRISNO ENTRIS , ADNYANA I. KETUT 
Published: December 2023

Objective: The study aimed to investigate the interactions between twelve extracellular enzymes and nuclear factor erythroid 2–related factor 2 (Nrf2) in the active site.
Methods: The Zdock web server was accessed to perform molecular docking simulations for predicting interactions between the extracellular enzymes and the active site of Nrf2. The Z score analysis revealed enzymes with high scores, indicating strong and statistically significant interactions with Nrf2.
Results: DNase 1, a-amylase, and lecithinase C exhibited notably high Z scores, suggesting potential key players in modulating Nrf2-mediated signaling pathways. The examination of salt bridges showed enzymes with more ionic interactions, suggesting enhanced stability and potential for strong binding within the active site of Nrf2. This characteristic might be crucial for enzymatic inhibition of Nrf2’s activity.
Conclusion: In conclusion, the findings highlight enzymes, including DNase 1, a-amylase, and lecithinase C, as promising candidates for further exploration as potential inhibitors of NRF2-mediated cellular responses.
META-TYROSINE CONJUGATES LABELED 64CU AND 68GA AS A CANCER RADIODIAGNOSIS AGENT USING MOLECULAR DOCKING SIMULATION ON LAT-1
Authors: HOLIK HOLIS ABDUL , ELAINE ANGELA ELYSIA , SITINJAK BERNAP DWI PUTRA , IBRAHIM FAISAL MAULANA , ACHMAD ARIFUDIN , SUDARMANTO B. S. ARI , HARYONO  , KARTAMIHARDJA ACHMAD HUSSEIN SUNDAWA 
Published: December 2023

Objective: This in silico study aims to determine the most potential compound of meta-tyrosine (JX-075, JX-078, and JX-119) 64Cu and 68Ga conjugated with various bifunctional chelating agents, NOTA, DOTA, and NODAGA, against the antiporter site of the LAT1 as conduct to develop a cancer diagnostic compound.
Methods: Molecular docking simulation was performed to investigate the interactions between meta-tyrosine compounds and LAT-1. Ligand compounds were drawn in 2D structures using ChemDraw Professional 16.0 and then labeled with 64Cu and 68Ga to build a radiopharmaceutical scaffold. The docking process was validated, characterized, and evaluated the interaction using several docking protocols in MOE 2020, a license owned by Gadjah Mada University. A visualization of the protein with the ligand was carried out on the BIOVIA Discovery Studio 2020.
Results: Docking simulation results show that JX119 has greater potential due to lower bond energy, JX119_NODAGA_68Ga of-9.22 kcal/mol and JX119_NODAGA_64Cu of-9.09 kcal/mol. This compound showed interactions with transporter amino acid sites Tyr259 and Phe252, both JX-119_NODAGA 68Ga and JX119_NODAGA_64Cu.
Conclusion: The compounds [64Cu]Cu-NODAGA-JX119 and [68Ga]Ga-NODAGA-JX119 are the most potential compounds with the lowest (most negative) Gibbs energy as conduct to develop a diagnostic compound.
Focus Group Discussion; Peluang, Tantangan dan Strategi Upaya Penyelamatan Pengungsi Luar Negeri di Laut
Authors: Faisal Faisal , Mukhlis Mukhlis , Muammar Muammar , Zulfadli Zulfadli , Putri Raihan , Putra Andhika Jaya 
Published: December 2023

Background: Indonesia merupakan salah satu negara yang dituju menjadi tempat pendaratan para pengungsi dari luar negeri, meskipun Indonesia belum melakukan ratifikasi pengungsi Tahun 1951 dan protokol Tahun 1967. Semakin banyaknya para pengungsi yang datang ke Indonesia khususnya Tanah Aceh akan mengakibatkan pemerintah daerah kewalahan dalam pemenuhan hak-hak pengungsi, misalnya hak untuk hidup, hak menempati sementara, hak sosial dan hak lain-lainnya. Tujuan kegiatan ini yaitu upaya untuk melindungi kawasan laut, lingkungan pantai, sanitasi di wilayah Aceh sebagai daerah yang sering terjadi pendaratan pengungsi luar negeri, serta strategi dalam menangangi pengungsi dari luar negeri sesuai standar internasional. Metode: Focus group discussion dengan cara diskusi tanya jawab, pemaparan materi sekaligus sosialisasi. Subyek dalam pengabdian ini meliputi panglima laot dan nelayan. Hasil: Hasil diskusi yaitu membuat rencana kontinjensi pada perlindungan kawasan laut dan menyelenggarakan tugas dan wewenang terkait penanganan pengungsi berdasarkan SOP internasional. Kesimpulan: Hambatan penanggulannya adalah ketidaksanggupan menampung jumlah pengungsi, kelayakan sarana dan prasarana sehingga dibutuhkan standar internasional. Diperlukan pengaturan khusus yang dibuat oleh pemerintah setempat untuk mengakomodir pengungsi luar negeri.
Screening of Rice Genotypes for Resistance Against Bacterial Blight Disease
Authors: Jirankali Jyoti P. , Deepak C. A. , Chethana B. S. , Sandesh G. M. , Nikhil G. , Rajanna M. P. 
Published: December 2023

A study was undertaken at V. C. Farm, Mandya, Karnataka, India during 2020 to screen the genotypes against BLB under natural field conditions. Host Plant resistance is an important component of an integrated management program for this disease. Among the 102 rice genotypes screened under natural epiphytotic condition at Zonal Agricultural Station, V. C. Farm, Mandya, none of them were found immune against bacterial leaf blight. So, in the study, plants were assessed by measuring disease severity (% of leaf diseased) and area under the disease progress curve (AUDPC). The pathogenicity of Xoo was tested on IRRI rice cultivars, inoculation was conducted at the maximum tillering stage, and the lesion length was measured after 14 days of inoculation. An attempt was made to phenotypically characterize a set of 102 Genotypes from IRRI for BLB resistance by artificially inoculaton using clipping method. Out of the 102 genotypes and two checks tested, it was observed that five entries viz., IRGC 125853, IRGC 126264, IRGC 132357, IRGC 122088 IRGC 125658 and Improved Samba Mahsuri were highly resistant with score of 1. Only one entry (IRGC 125754) was resistant with score of 3, 33 lines being moderately resistant with score of 5 and 43 lines were susceptible with score of 7. 20 lines and also the susceptible check Jyothi-PTB 39, had the highest susceptibility with a phenotypic score of 9.
Teoria do Flogisto: uma abordagem didática para o ensino de reações químicas no 9º ano do Ensino Fundamental
Authors: Luca Anelise Grünfeld de , Walz Gabriel Cristiano 
Published: December 2023

ResumoO presente artigo é resultado de uma intervenção pedagógica desenvolvida em 2018 em uma escola pública do município de Joinville – SC. O objetivo foi desenvolver uma sequência didática para o estudo das reações químicas por meio da abordagem da Teoria do Flogisto como propulsora de discussões sobre a construção do conhecimento científico e a experimentação investigativa como forma de possibilitar metodologias ativas aos estudantes. A questão problema investigada foi: em que medida a Teoria do Flogisto viabilizou a aprendizagem das reações químicas para os estudantes do 9º ano do Ensino Fundamental? A Teoria do Flogisto sinalizou a importância de apresentar e discutir de que maneira os conhecimentos científicos foram construídos por meio de continuidades e descontinuidades. Mediante a experimentação e as discussões sobre a reação de combustão, foi possível compreender os entendimentos dos estudantes para além de um ensino conteudista, principalmente a interação dos estudantes com aquilo que ocorre ao seu redor.Palavras-chave: Teoria do Flogisto, reação química, 9º ano, Ensino Fundamental AbstractThis article is the result of a pedagogical intervention developed in 2018 in a public school in the city of Joinville - SC. The aim was to develop a didactic sequence for the study of chemical reactions through the approach of the Phlogiston Theory as a propeller of discussions about the construction of scientific knowledge and investigative experimentation as a way to enable active methodologies to the students. The problem question investigated was: to what extent did the Theory of Phlogiston enable the learning of chemical reactions for students in the 9th grade of elementary school? The Phlogiston Theory showed the importance of presenting and discussing how scientific knowledge was built through continuities and discontinuities. Through experimentation and discussions about the combustion reaction, it was possible to understand the students 'understandings beyond a content teaching, especially the students' interaction with what happens around them.Keywords: Phlogiston Theory, Cemical reaction, 9th grad, elementary school
EDUCAÇÃO LINGUÍSTICA NA FORMAÇÃO DO PROFESSOR DE LÍNGUA PORTUGUESA: REFLEXÕES PARA A PEDAGOGIA LÉXICO-GRAMATICAL
Authors: Butti Cassiano 
Published: December 2023

Este trabalho se insere na área da Educação Linguística e tematiza a importância dos conhecimentos léxico-gramaticais na formação do professor de língua portuguesa. Tem por objetivo contribuir para as discussões voltadas para a teorização de uma pedagogia léxico-gramatical. Problematiza-se o desconhecimento, por parte do professorado em formação ou já formado, de estratégias para a realização de análises linguísticas a partir de seu principal objeto de trabalho: os textos. Justifica-se o estudo pelo número incipiente de estudos que demonstrem como abordar os conhecimentos léxico-gramaticais numa transversalidade com as atividades de produção e recepção de textos escritos e orais. Fundamenta-se o artigo nas investigações em Educação Linguística (BECHARA, 1986; FIGUEIREDO, 2004, LOMAS 2003; 2014; PALMA; TURAZZA, 2014; GALLINA 2019).
¿El movimiento feminista crea espacio urbano y nuevas maneras de (re)generar la ciudad? Un acercamiento al caso de Montevideo, Uruguay
Authors: Cardozo Delgado Sofía , Torre Nicolini Valentina 
Published: December 2023

El presente artículo explora cómo los movimientos feministas en Montevideo han construido ciudad a través de la apropiación de espacios urbanos que promueven formas de habitar diversas. Se realiza un abordaje desde el concepto de derecho a la ciudad y la perspectiva del urbanismo feminista, que busca considerar las necesidades de grupos históricamente excluidos. Para ello, resulta fundamental reconocer que las ciudades han sido diseñadas desde una perspectiva masculina y analizar cómo los conflictos urbanos tienen su raíz en las violencias que experimentan las mujeres en su vida diaria y en la necesidad de resignificar y reclamar esos espacios. Se plantea un abordaje situado, atendiendo a las características de las nuevas formas de estar en el espacio público por parte de los feminismos latinoamericanos. A partir de la realización de un amplio análisis documental, entrevistas y observaciones sistemáticas, se profundiza en cómo el feminismo construye ciudad de diversas formas, tanto a nivel institucional como en la vida cotidiana. Resulta fundamental comprender los efectos que los movimientos feministas tienen en el ámbito urbano y la necesidad de identificar y abordar las conquistas, negociaciones, disputas y dificultades entre los diferentes actores involucrados. Así, e incorporando los aportes del urbanismo feminista, se aborda la capacidad de producción de estos conflictos, siguiendo la propuesta de Melé (2016), y se las categoriza en productividades de tipo políticas, jurídicas y territoriales. Se concluye que los efectos del movimiento feminista generan nuevas posibilidades para la construcción de una ciudad más justa.
Effect of Substituting White Cement with Ceramic Waste Powders (CWP) on the Performance of a Mortar Based on Crushed Sand
Authors: Mezidi Amar , Merabti Salem , Benyamina Smain , Sadouki Mustapha 
Published: December 2023

Abstract
The enormous quantities of ceramic waste lead us to its use in the construction field to solve both an environmental and an economic problem. The present study aims to recycle ceramic waste powders (CWP) to produce mortars. To this end, five crushed sand (CS) based mortar mixes with prismatic dimensions of 4x4x16 cm³ were prepared by partially replacing 0, 5, 10, 15, and 20% white cement with CWP. Tests were carried out to assess bulk density, compressive strength, and ultrasonic pulse velocity (UPV). The results obtained showed that increasing the proportion of ceramic waste powder (CWP) in mortar mixes led to a decrease in bulk density, compressive strength, and UPV in the different mortars. In addition, linear correlations were observed between the different variables studied.
The use of rural cultural tourism product development strategy based on artificial intelligence technology
Authors: Zhou Shuyun 
Published: December 2023

Abstract
Based on artificial intelligence technology, this paper emphasizes user-centered tourism product development, focusing on the importance of meeting tourists’ core needs. The AI product development process is explained in detail, including the essential steps of intelligent image analysis and personalized recommendation. Tourist attractions are presented using image preprocessing algorithms, and intelligent image analysis is employed to analyze tourists’ interest preferences and create personalized image recommendations. Next, edge-aware intelligent visual guidance is employed to highlight cultural elements and target product development. Finally, the feasibility of the strategy for developing rural tourism products is confirmed. From January to December, the sales of tourism product development based on AI technology increased from 15,000 yuan to 38,200 yuan, which provides strong guidance for tourism operators.
Design and Development of Traditional Elements in Visual Communication Design under the Integration of Virtual Reality Technology
Authors: Shen Jiumei , Zhang Xiang , Zhang Lei , Hu Lingling 
Published: December 2023

Abstract
This paper proposes a method based on visual communication to generate two-dimensional motion graphics that can enhance the perception of depth and three-dimensional structure in stereoscopic vision. Through eye tracking and calibration, gaze points in 3D space are calculated and applied to Chinese traditional elements in visual communication design. Feature vectors and improved plain Bayesian classifier methods are used to achieve user gesture recognition in virtual design and construct interaction design scenarios based on virtual reality technology. Lastly, the performance impact of augmented reality technology on traditional element design is investigated through a questionnaire survey. Based on the eight samples of conventional elements, the evaluation factors with the highest scores were found to be 10. In the subjective assessment of visual communication design, traditional components fall between mediocre and good, according to the ratings of all 18 assessment factors, which range from 0.2 to 1. The study presented in this paper effectively integrates virtual reality technology into the graphical design of traditional elements, significantly enhancing their visual expression.
Research on the Path of Enhancing Physical Education Teaching in Colleges and Universities Based on the Background of Deep Learning
Authors: Liang Rongfa 
Published: December 2023

Abstract
This paper firstly summarizes the factors affecting the ability of physical education teaching from the four points of society, family, school and teachers, and puts forward the path of physical education teaching enhancement in colleges and universities in view of the current dilemma of physical education teaching. Secondly, in the context of deep learning, the use of deep learning for the calculation of the human center of gravity information can improve the efficiency of human center of gravity vector angle feature extraction while using the vector pinch angle cosine body force to obtain the human limb pinch angle features, followed by posture estimation method to obtain the body upper and lower body orientation features, and then through the improved Open Pose network model will be converted from video stream data to the human body key point coordinates data, and then the ALSTM-LSTM model will be applied to the video stream data. Then, the ALSTM-LSTM model was applied to the sports teaching movement analysis and empirically analyzed for sports teaching in colleges and universities. According to the findings, the ALSTM-LSTM model has the best performance in all indexes, while the SVM has the worst performance. In physical education, through quality practice in the classroom, the reinforcement of the sports club and the maintenance of the extracurricular group “Gudong” running, the students’ physical indicators have been improved. This study is conducive to improving the current decline in college students’ physical health and is also of great practical significance in effectively improving the overall level of college students’ physical fitness.
Optimization of urban intelligent transportation travel service system based on feature extraction and traffic prediction
Authors: He Chunhong 
Published: December 2023

Abstract
The urban intelligent transportation travel service system can effectively improve the quality of transportation travel, but the current system has certain deficiencies. This paper from two aspects to improve and analyze. On the one hand, the point-level artificial features are modeled through relevant mathematical models, and the citizens’ travel feature extraction model is designed based on a stack self-encoder after smoothing the artificial features. On the other hand, a traffic flow prediction model was designed through the temporal and spatial features of urban traffic, respectively, and combined with the spatio-temporal correlation feature design to predict the urban traffic flow. In addition, the effects of travel mode extraction and traffic flow prediction are analyzed to explore the optimization effect of the travel system. The results show that when the time value is taken as the 90s, the corresponding coding sparsity and weight are obtained as 50 and 0.05, respectively, and the average accuracy and average recall of the traffic modes reach 0.9. When the number of neurons is set to 30, the gap of the traffic flow in the peak is about 80, the gap of the traffic flow in the rest of the time period is about 10, and the relative error value is within 0.1. This study is able to optimize the intelligent traffic travel service system.
Experimental and Numerical Assessment of Bonding Between Geopolymer Concrete and CFRP Sheet Using NSM Techniques
Authors: Al-Abdwais Ahmed H. 
Published: December 2023

Abstract
Geopolymer concrete is a new concrete technology that emerged as an alternative to conventional concrete by replacing traditional Portland cement with geopolymer binders. Strengthening of concrete structures using CFRP composites has become an essential technique last decades. Most of the studies were conducted on conventional concrete of Portland cement. In this research, an experimental and finite element analysis has been conducted to assess the bonding properties between geopolymer concrete substrate and CFRP composites using near-surface mounted strengthening system. The program consisted of concrete prisms bonded with NSM CFRP laminate and tested using single-lap shear test set-up with different bond lengths. Bond-slip behaviour has also been evaluated. The experimental results exhibited significant bonding properties, achieving an average bonding stress between 8.97 and 15.58 relative to the bonding length. The numerical analysis showed comparable results and a good correlation with that of experimental work.
Effects of Intravenous Glucose on Blood Potassium in Cattle
Authors: Mudroň Pavol , Helin Emma 
Published: December 2023

Abstract
The aim of this study was to confirm whether a rapid intravenous glucose administration can lead to a significant drop in blood potassium levels in cattle. For this study, seven cattle were used according to internationally recognized guidelines for animal welfare. Glucose at a dose of 1 g.kg−1 body weight was administrated intravenously and then blood samples were taken before and 0.5, 1, 2, 4, and 6 hours after administration of glucose for measurement of potassium and glucose blood concentrations. For statistical analysis of glucose effects on both glucose and potassium levels one-way analysis of variance (ANOVA) for repeated measures was used. ANOVA showed a strong significant effect of the glucose administration on plasma glucose levels (P < 0.001). The glucose administration resulted in a mean plasma increase from 4.2 mmol.l−1 to 21.2 mmol.l−1 within the first minutes after the administration followed by a steady decrease back to the initial values. In contrast, ANOVA showed no significant effect of the glucose administration on plasma potassium levels. In conclusion, the glucose does not have a potassium-lowering effect when administered in a single large intravenous dose.