bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromatin-mediated silencing on the inactive X chromosome
Authors: Keniry Andrew , Blewitt Marnie E. 
Published: November 2023

ABSTRACT
In mammals, the second X chromosome in females is silenced to enable dosage compensation between XX females and XY males. This essential process involves the formation of a dense chromatin state on the inactive X (Xi) chromosome. There is a wealth of information about the hallmarks of Xi chromatin and the contribution each makes to silencing, leaving the tantalising possibility of learning from this knowledge to potentially remove silencing to treat X-linked diseases in females. Here, we discuss the role of each chromatin feature in the establishment and maintenance of the silent state, which is of crucial relevance for such a goal.
Diversity Subsampling: Custom Subsamples from Large Data Sets
Authors: Shang Boyang , Apley Daniel W. , Mehrotra Sanjay 
Published: November 2023

Subsampling from a large unlabeled (i.e., no response values are available yet) data set is useful in many supervised learning contexts to provide a global view of the data based on only a fraction of the observations. In this paper, we borrow concepts from the well-known sampling/importance resampling technique, which samples from a specified probability distribution, to develop a diversity subsampling approach that selects a subsample from the original data with no prior knowledge of its underlying probability distribution. The goal is to produce a subsample that is independently and uniformly distributed over the support of distribution from which the data are drawn, to the maximum extent possible. We give an asymptotic performance guarantee of the proposed method and provide experimental results to show that the proposed method performs well for typical finite-size data. We also compare the proposed method with competing diversity subsampling algorithms and demonstrate numerically that subsamples selected by the proposed method are closer to a uniform sample than subsamples selected by other methods. The proposed diversity subsampling (DS) algorithm is more efficient than known methods. It takes only a few minutes to select tens of thousands of subsample points from a data set of size one million. Our DS algorithm easily generalizes to select subsamples following distributions other than uniform. We provide a Python package (FADS) that implements the proposed method.History: Kwok-Leung Tsui served as the senior editor for this article.Funding: This work was supported by the National Science Foundation [Grant CMMI-1436574], Northwestern University, the Advanced Research Projects Agency-Energy, and the U.S. Department of Energy [Award DE-AR0001209].Data Ethics & Reproducibility Note: No data ethics considerations are foreseen related to this article. The code capsule is available on Code Ocean at https://doi.org/10.24433/CO.8309237.v3 and in the e-Companion to this article (available at https://doi.org/10.1287/ijds.2022.00017 ).
Multiproduct Dynamic Pricing with Limited Inventories Under a Cascade Click Model
Authors: Najafi Sajjad , Duenyas Izak , Jasin Stefanus , Uichanco Joline 
Published: November 2023

Problem definition: Designing effective operational strategies requires a good understanding of customer behavior. The classic economic theory of customer choice has long been the paradigm in the operations literature. However, the rise of online marketplaces such as e-commerce has triggered considerable efforts in academia and industry to develop alternative models that not only provide a good approximation of customer behavior but also are easily scalable for large-scale implementations. In this paper, we consider a multiproduct dynamic pricing problem with limited inventories under the so-called cascade click model, which is one of the most popular click models used in practice and has been intensively studied in the computer science literature. Methodology/results: We present some fundamental results. First, we derive a sufficiently general characterization of the optimal pricing policy and show that it has a different structure than the optimal policy under the standard pricing model. Second, we show that the optimal expected total revenue under the cascade click model can be upper bounded by the objective value of an approximate deterministic pricing problem. Third, we show that two policies that are known to have strong performance guarantees in the standard revenue management setting can be properly adapted (in a nontrivial way) to the setting with cascade click model while retaining their strong performance. Finally, we also briefly discuss the joint ranking and pricing problem and provide an iterative heuristic to calculate an approximate ranking. Managerial implications: Taking into account customers’ click-and-search behavior leads to different structures of the optimal pricing policy, and some common insights under the standard pricing models may no longer hold. Moreover, our simulation studies show that pricing under a (misspecified) classic choice model that is oblivious to customers click-and-search behavior can severely impact profitability. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2021.0504 .
YOUNG PEOPLE AND FAMILY RURAL PROPERTIES IN THE WEST REGION OF PARANÁ
Authors: Mario Bernardo Luciana Virginia , Rippel Ricardo , Ulisses Saraiva Farinha Maycon Jorge , Soares Filho Adelsom 
Published: November 2023

In this article, we investigated how young people in the municipality of Assis Chateaubriand perceive the rural space and family rural property succession. The municipality of analysis has traditionally used land for agricultural production, and as a result, its economic development is influenced by it. A questionnaire was used to collect data from 153 young people from the municipality ranging in age from 14 to 29. To obtain the results, several steps were taken, including descriptive statistics, factor analysis, and content analysis. We found that young people do not see themselves as essential elements for the continuity of the family's rural property. In this sense, it is necessary to develop activities that encourage dialogues on the succession process in rural properties in the region, on the initiative of public or private agents
A FILOSOFIA DA RELAÇÃO DE ÉDOUARD GLISSANT:
Authors: Ferreira dos Santos Luís Carlos 
Published: November 2023

O texto navega pela paisagem filosófica do filopoeta martinicano Édouard Glissant, no objetivo de apresentar uma breve introdução de seu pensamento. Para isso, parte da compreensão dos arquipélagos textuais do autor, buscando compreender como a filosofia da relação pode ser um campo de disputa e compreensão da cidadania e enfrentamento da violência racial e, por fim, examina o papel da literatura no seu projeto filosófico.
Palavras - Chave: Édouard Glissant. Filosofia da Relação. Arquipélago. Filosofia Afrodiaspórica
A subtil estratégia discursiva de Innocentia Victrix (1671)
Authors: Ascenso André Carlos 
Published: November 2023

A forte presença da Companhia de Jesus na China sofreu um rude golpe, entre 1664 e 1671, que culminou em longo processo judicial: perseguições, prisões, exílio e, mesmo, a morte de alguns dos padres. Do lado dos poderes e do lado dos acusados, houve requerimentos, libelos, editos, sentenças, de conteúdos por vezes estranhos e, sobretudo, contraditórios. Tais peças processuais foram reunidas em livro, sob o título Innocentia Victrix - “Inocência Triunfante” ou “Triunfo da Inocência” – atribuído a António de Gouveia, Vice-provincial da Companhia de Jesus, e publicado em Guangzhou, em 1671, em chinês e em latim. O livro, porém, é mais do que a simples junção de peças processuais: o responsável pela organização (e pelo sugestivo título, nada inocente) interfere muitas vezes no texto, mesmo no interior das peças judiciais, com pareceres, comentários, interpretações, juízos de valor.
O objetivo deste trabalho é fazer uma leitura em pormenor desse texto, nas suas linhas e nas suas entrelinhas, identificar a possível estratégia do seu responsável e integrá-la na estratégia da Companhia de Jesus.
Evaluasi Efektivitas Pengolahan Air Limbah pada Instalasi Pengolahan Air Limbah Klinik Kecantikan
Authors: Rahman Miftahhur , Akbar Aji Ali , Anwari Muhammad Sofwan 
Published: November 2023

Gaya hidup saat ini mendorong masyarakat untuk memiliki kulit bersih dan terawat sehingga kebutuhan akan pelayanan klinik perawatan wajah semakin meningkat. Klinik kecantikan umumnya melayani perawatan wajah diantaranya pembersihan kulit, pemutihan kulit, dan perawatan wajah. Klinik kecantikan menghasilkan buangan yang sebagian besar berasal dari wastafel sebagai hasil aktivitas perawatan kulit dan umumnya mengandung kadar organik karena berasal dari sisa anggota tubuh. Limbah yang mengandung zat organik tinggi, akan mempengaruhi kualitas badan air jika tidak diolah sebelum dibuang ke badan air sekitar sehingga mengurangi nilai oksigen terlarut di badan air dan dapat menganggu aktivitas ekosistem perairan. Berdasarkan pemaparan tersebut maka perlu dibuat suatu penelitian untuk mengevaluasi pengolahan limbah pada IPAL klinik kecantikan. Penelitian ini bertujuan menganalisis parameter limbah dan efektifitas IPAL dalam mengolah limbah serta langkah yang diperlukan berdasarkan hasil analisa. Metode pengambilan sampel dipilih menggunakan metode komposit kemudian sampel di analisa di laboratorium yang terakreditasi. Hasil penelitian dengan tingkat kepercayaan 95% menggunakan software SPSS 25 membuktikan bahwa terdapat perbedaan nyata kualitas limbah sebelum dan sesudah diolah pada IPAL. Efisiensi tertinggi untuk parameter pH sebesar 1,53% di hari ketiga, efisiensi tertinggi untuk parameter BOD sebesar 95,38% di hari pertama, efisiensi tertinggi untuk parameter COD adalah sebesar 95,67% pada hari pertama, efisiensi tertinggi untuk parameter TSS adalah 91,10% pada hari pertama, efisiensi tertinggi untuk parameter minyak dan lemak adalah 80,37% pada hari ketiga, efisiensi Ammonia tertinggi adalah sebesar 32,56% pada hari kedua, dan efisiensi tertinggi untuk parameter total coliform adalah 67,44% pada hari ketiga. Strategi untuk menjaga efektifitas IPAL adalah dengan membersihkan bak dan saluran IPAL agar tidak sumbat, memastikan kondisi pH tetap terjaga di rentang 6-9, mengatur aerasi yang terus menerus, stabil dan tidak berkurang kuantitasnya, memastikan biofilm bakteri tidak menyebabkan clogging, tidak menghilangkan 100% lapisan biofilm, serta pemberian starter bakteri untuk mengurai zat pencemar didalam air limbah.
Strategi Pengembangan Taman Keanekaragaman Hayati (Taman Kehati) Lahan Eks TPA Menjadi Pariwisata Hijau Melalui Pendekatan Perencanaan Partisipatif
Authors: Nurhidayati Dwiana , Iqbal Achmad , Abrar Rahab 
Published: November 2023

Pariwisata digambarkan sebagai suatu sistem yang menghubungkan wisatawan (dari sisi permintaan) dan tujuan wisata (daya tarik dari sisi penawaran). Pariwisata juga dianggap sebagai aktivitas pelayanan, pendapatan dan dampak ekonomi bagi penyedia, masyarakat sasaran dan pemerintah Lokasi penelitian dilakukan di Taman Keanekaragaman Hayati lahan eks TPA Kemutug Lor RW 3 Desa Kemutug Lor Kecamatan Baturraden Kabupaten Banyumas. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan deskriptif. Penentuan sumber data pada informan yang diwawancarai dilakukan secara purposive. Diperoleh hasil 8 stategi guna mengembangkan Taman Kehati lahan eks TPA menjadi pariwisata hijau melalui pendekatan perencanaan partisipatif di desa Kemutug Lor yaitu : melakukan pengembangan wisata, melakukan kerjasama promosi wisata, melakukan penyediaan dan perbaikan sarana prasarana, membangun kemitraan yang harmonis, melakukan sosialisasi kepada masyarakat lokal, meningkatkan dan mempertahankan kearifan, melakukan penataan lingkungan dan pengelolaan kawasan dan memberikan pelatihan pemberdayaan masyarakat dan pengelola.
Pengaruh Emisi Kendaraan Terhadap Kandungan Logam Timbal (Pb) Tanah dan Bulir Padi pada Lahan Sawah di Kecamatan Tebas Kabupaten Sambas
Authors: Manurung Rinto , Oktoriana Shenny , Suharyani Anita 
Published: November 2023

Lead (Pb) is one of most toxic pollutants. The main sources of Pb comes from industrial and vehicle gases. Lead contained in gas from vehicle will be absorbed and accumulated in the soil. Leads in the soil, especially in paddy soil alongside highway with many vehicles have a potential to be absorbed and accumulated in the grain. Solubility of Pb in the soil affecting the absorption of paddy is controlled by soil properties such as texture, organic matter, pH and cation exchange capacity. The research aims to study the effect of vehicle emission on Pb content in the soil, soil properties that influences the presences of Pb in the soil and its accumulation in grain. The research was conducted in paddy soil located alongside the highway of Sambas Regency as a rice producing center in West Kalimantan. Distance of soil and grain samplaing from the road will be used as a treatment to observe the effect of vehicle emission on Pb content, ie 0 – 50 meters, 50 – 100 meters and more than 100 meters. Soil samples were taken at 0-20 cm and 20-50 cm depth. Soil samples and grains are destracted by using nitric acid, hydrogen peroxide and perchloric acid. Furthermore, Pb content was measured using Atomic Absorbtion Spectrophotometry (AAS). The results showed that there is no effect of land distance from the road to the soil content. The average Pb content at 0-50 m, 50-100 m and more than 100 m at a depth of 0-20 cm were 29,62 ppm, 31,57 ppm and 35,03 ppm, respectively. While the average Pb content at a depth of 20-50 cm, respectively, were 27,16 ppm, 32,53 ppm and 35,97 ppm. The presence of Pb in the soil is significantly correlated with sand and clay fraction. The content of Pb on grains is above the tolerance limit (0,5 ppm) of Pb content in food, fruits and vegetables. Pb content is from 2,07 ppm to 5,10 ppm.
Karakteristik Sampah Sungai dan Perilaku Masyarakat Pesisir Terhadap Sampah Plastik: Studi Kasus di Sungai Pengarengan, Kabupaten Cirebon
Authors: Astuti Ayu Dwi , Frimawaty Evi , Dwiyitno Dwiyitno 
Published: November 2023

Penggunaan plastik terus meningkat seiring dengan bertambahnya populasi. Sayangnya, konsumsi plastik yang tinggi tidak diikuti dengan pengelolaan yang tepat sehingga menyebabkan sampah plastik yang berasal dari darat masuk ke badan sungai kemudian berakhir di wilayah pesisir dan mencemari lingkungan. Penelitian ini dilakukan di Desa Pengarengan, Kabupaten Cirebon, Jawa Barat. Sungai Pengarengan merupakan jalur transportasi kapal nelayan menuju Laut Jawa, sehingga aktivitas masyarakatnya yang tinggi berpotensi menimbulkan pencemaran sampah ke lingkungan sekitarnya. Tujuan penelitian ini adalah menganalisis karakteristik sampah plastik serta mengevaluasi hubungan antara aspek pengetahuan dengan perilaku masyarakat terkait sampah plastik yang mencemari lingkungan. Metode yang digunakan adalah kelimpahan pelepasan sampah dan puing-puing sampah dikumpulkan di dua titik sampling dengan menggunakan jaring yang memiliki ukuran mata jaring 5cm, dipasang pada waktu pagi hari sesuai lebar sungai. Data perilaku masyarakat terhadap sampah plastik diperoleh dari 110 responden dengan menggunakan teknik accidental sampling. Hasil penelitian menunjukkan total kelimpahan puing sampah sungai adalah 13200 ± 1678 item dan 14976 ± 1772 item. Kelimpahan puing sampah sungai tertinggi adalah bungkus sampah plastik tipis sebanyak 47% dan 46%, diikuti kayu ranting (39% dan 33%), styrofoam (3,6% dan 5,5%), sedotan (1,8% dan 2,2%), gelas plastik (1,5% dan 2,6%), kotak makanan, peralatan plastik, dll (1,4% dan 1,6%), serta plastik lainnya (2,2% dan 2,3%). Analisis statistik Kruskal Wallis menunjukkan tidak terdapat perbedaan yang siginifikan terhadap kelimpahan total puing sampah plastik sungai di kedua titik sampling p= 0,875 (p> 0,05). Hasil evaluasi perilaku masyarakat menunjukkan bahwa aspek pengetahuan memiliki kategori penilaian sangat baik (4,08), aspek sikap dengan kategori kurang baik (2,89), dan aspek perilaku dengan kategori baik (3,88). Analisis korelasi Pearson menunjukan terdapat hubungan positif yang kuat (r= 0,664) dan signifikan (sig.= 0,000) antara aspek pengetahuan dengan perilaku. Aspek sikap dengan perilaku mempunyai hubungan positif yang lemah (r=0,183) dan signifikan (0,028).
Model Pengelolaan Sampah Organik dengan Biokonversi Larva Black Soldier Fly Berbasis Pemberdayaan Masyarakat.
Authors: Zahra Afifah , Herdiansyah Herdis , Utomo Suyud Warno 
Published: November 2023

Sampah masih menjadi salah satu masalah di Indonesia. Sejak tahun 2017, volume sampah yang terangkut di Indonesia masih belum memenuhi target, termasuk di Desa Tubanan, Kecamatan Kembangan, Kabupaten Jepara, Jawa Tengah. 30-63% sampah yang dihasilkan adalah sampah organik. Pengelolaan sampah dengan biokonversi larva Black Soldier Fly dapat menjadi solusi untuk permasalahan sampah di Indonesia. Karena manfaatnya dapat mereduksi 80% sampah dan dapat membentuk ekonomi sirkular untuk masyarakat. Keuntungan ekonomi dapat didapatkan dari hasil penjualan produk ataupun pengurangan biaya pengelolaan sampah. Pengolahan sampah dengan biokonversi larva Black Soldier Fly tidak berdampak padak kesehatan masyarakat dan tidak menimbulkan bau. Sehingga, pengolahan sampah dengan biokonversi larva Black Soldier Fly dapat menjadi salah satu alternatif dalam menyelesaikan permasalahan sampah di Indonesia. Tujuan dari penelitian ini adalah memformulasikan model pengelolaan sampah organik dengan biokonversi larva Black Soldier Fly berbasis pemberdayaan masyarakat dalam aspek lingkungan, sosial, ekonomi, dengan perlakuan formula nutrisi pakan yang tepat. Penelitian ini dilakukan dengan menganalisis keuntungan yang didapatkan di antara 3 jenis sampah sebagai formula nutrisi pakan (sampah dari masyarakat, sampah sisa pemotongan ikan, dan sampah campuran dari keduanya). Analisis menggunakan sistem dinamik dan analisis statistik menggunakan SPSS. Berdasarkan simulasi model yang telah dilakukan, nilai ekonomi tertinggi dihasilkan oleh intervensi penggunaan sampah campuran antara sampah dari masyarakat yang dapat terolah 100% dan sisa pemotongan ikan. Selain itu sampah campuran juga dapat menghasilkan total biomassa product tertinggi dibandingkan jenis sampah lainnya. Maka, dapat disimpulkan bahwa model pengelolaan sampah organik dengan biokonversi larva Black Soldier Fly berbasis pemberdayaan masyarakat menggunakan sampah campuran (sampah dari masyarakat yang dapat terolah 100% dan sisa pemotongan ikan) dapat dipilih sebagai metode pengelolaan sampah yang tepat di Desa Tubanan, Kecamatan Kembangan, Kabupaten Jepara, Jawa Tengah.
Die Bibliothek des biologischen, technischen und kulturellen Wissens – Warum brauchen wir eine integrierte Sammlungsinfrastruktur?
Authors: Misof Bernhard , Tockner Klement , Trischler Helmuth 
Published: November 2023

Zusammenfassung
Die bundesweiten Forschungssammlungen umfassen mehr als 150 Millionen natur-, technik- und kulturhistorische Objekte. Hinzu kommen vielfältige Sammlungen von Lebendkulturen in Bioressourcenzentren. Das Konsortium OSIRIS (Offene Sammlungs-, Informations- und Rechercheinfrastruktur) fokussiert sich darauf, das immense Potenzial dieser Sammlungen für Forschungsfragen und konkrete Anwendungen gemeinsam zu erschließen, um gesellschaftliche Veränderungsprozesse zu verstehen, mitzugestalten und eine neue Wissensökonomie zu schaffen. Der Beitrag diskutiert die Frage, was eine integrative Bibliothek des biologischen, technischen und kulturellen Sammlungswissens leisten kann.
Treatment of gastric cancer by green mediated silver nanoparticles using Pistacia atlantica bark aqueous extract
Authors: Dang Ling , Yang Jian , Negm Sally , El-kott Attalla F. , Shati Ali A. , Ghamry Heba I. , Karmakar Bikash 
Published: November 2023

Abstract
We herein demonstrate a novel green mediated silver nanoparticles (AgNPs) using Pistacia atlantica bark aqueous extract for the treatment of gastric cancer under in vitro conditions. Physicochemical and structural features of the nanocomposite biomaterial were assessed by several techniques like UV-Vis spectrum, transmission electron spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and inductively coupled plasma-optical emission spectroscopy. The Ag NPs showed high antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH). The IC50 of Ag NPs and Butylated hydroxytoluene against DPPH were 132 and 77 µg/mL, respectively. In the oncological part of this research, the status of normal and gastric cancer AGS and KATO III cell lines was determined. The IC50 of AgNPs was 193 and 250 µg/mL against AGS and KATO III. It seems that the prepared NP have stopped the growth of gastric cancer cells and the recent cancer cells have been removed with high concentration of NPs.
Deformations of astheno-Kähler metrics
Authors: Sferruzza Tommaso 
Published: November 2023

AbstractThe property of admitting an astheno-Kähler metric is not stable under the action of small deformations of the complex structure of a compact complex manifold. In this study, we prove necessary cohomological conditions for the existence of curves of astheno-Kähler metrics along curves of deformations starting from an initial compact complex manifold endowed with an astheno-Kähler metric. Furthermore, we apply our results providing obstructions to the existence of curves of astheno-Kähler metrics on two different families of real eight-dimensional nilmanifolds endowed with invariant nilpotent complex structures.
Biotechnological methods of growing sunflower in different fertilizer systems
Authors: Sokolovska Iryna , Maschenko Yuriy 
Published: November 2023

Abstract
The presented results of the study on the effect of biopreparations and different fertilizer systems on the formation of sunflower yield and productivity, determination of economic efficiency of sunflower cultivation under sharp fluctuations in climatic conditions through the use of biotechnology elements and fertilization. Growing sunflower without seed treatment with biopreparations under mineral fertilizer system provided an average yield of 2.93 t/ha, with an additional 0.31 t/ha of sunflower seeds. The organo-mineral fertilizer system resulted in the highest increase in additional production – 0.50 t/ha, and the increase in sunflower yield through fertilization system was the most significant, with a minimum important difference (MID05) of 0.11 t/ha. Seed treatment with biopreparation contributed to an increase in sunflower yield in all fertilizer systems: without fertilizer application, only due to the action of biopreparation, the yield increased to 2.82 t/ha; application of mineral fertilizer ensured a harvest of 3.09 t/ha of sunflower seeds; the organo-mineral fertilizer system had the highest yield indicator – 3.23 t/ha. The highest output of dry matter from the production was obtained through seed treatment with biopreparation and the use of organo-mineral fertilizer system, which provided a yield per hectare of: grain units – 6.47 t, fodder units – 3.56 t, digestible protein – 1.23 t. However, the most significant increase in sunflower productivity was observed in the organo-mineral fertilizer system without seed treatment with biopreparation. The highest indicators of economic efficiency of sunflower cultivation were observed under the conditions of seed treatment with biopreparation without fertilizer application, which amounted to 18,322 UAH/ha – net profit at a profitability of 91.5 %.