bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elements of E-Learning that Facilitate or Hinder Learning Motivation: A Review
Authors: Jrall Reecha , Kiran  
Published: December 2023

A new way of teaching has been spawned in the wake of the rapid growth of sophisticated technology. Digital technologies in some way enable the teachers to create teaching material that is more interesting because the learning is tailored to the needs of the students related to their upcoming professional workplaces. Moreover, students can easily and efficiently find learning materials by utilizing digital technology in the classrooms. Student participation in the classroom is increased, as is collaboration within the class. This can allow the student's proficiency to improve. Also, integrating digital technology in the classroom can create an enjoyable teaching-learning process, resulting in a positive attitude to learners, and they become motivated to participate in learning activities. Students can also become distracted or digress when using digital technology in English for Specific Purpose classrooms, for example, when using YouTube or smartphones in the learning process. As we know motivation is the key factor behind learning especially in educational institutions where teachers are the only source of motivation but through the interventions of digital technology learning become e-learning. In electronic teaching learning system presence of teacher is there but what are the other motivational factors in e – learning system that reinforces the learning of students. In the backdrop of this present paper explored the elements in e-content and e learning that act as a motivational element for students in virtual teaching learning process. in this paper researcher conducted a meta-analysis of the past researches conducted on e- learning and motivation. The results of the study points out that e-content and e-learning having interactive features like animation, better organization, collaborative features enhance the learning motivation of students.
Construction of Multi‐Module RNA Nanoparticles Harboring miRNA, AIE, and CH6 Aptamer for Bone Targeting and Bone Anabolic Therapy
Authors: Cai Bolei , Dong Jiachen , Su Bo , Yang Qiutong , Wang Chenrui , Yang Luying , Song Zhongchen , Liu Jiang , Jin Ronghua , Li Yan 
Published: December 2023

AbstractBone healing remains a major challenge in the treatment of osteoporosis. Effective strategies that simultaneously promote bone formation and inhibit bone resorption are crucial for the treatment of osteoporosis and associated bone defects. MicroRNA (miRNA)‐based approaches aim at simultaneously promoting bone formation and suppressing bone resorption and have therapeutic potential. However, the toxicity of cationic carriers and off‐target effects are two major challenges associated with miRNA delivery. This study establishes a bone‐targeting miRNA delivery system (CH6‐SNA‐26a) that integrates aggregation‐induced emission (AIE), a CH6 aptamer, and miRNAs into a single nanoplatform without any cationic carrier. In this system, an AIE molecule is coupled to miR‐26a to form a core–shell spherical nucleic acid (SNA‐26a). The CH6 aptamer is co‐assembled with the SNA to achieve specific miR‐26a delivery to the bone surface. This aptamer‐functionalized, non‐cationic miR‐26a delivery strategy (CH6‐SNA‐26a) enables both bone‐targeted delivery and high transfection efficiency, ultimately optimizing bone remodeling and calvarial bone healing in an osteoporosis mouse model while limiting adverse effects in non‐skeletal tissues. Mechanistically, the overexpression of CH6‐SNA‐26a in skeletal tissues promotes bone anabolic action by functionally targeting glycogen synthase kinase 3 beta in bone marrow mesenchymal stem cells and cellular communication network 2 in osteoclasts.
Great Challenges and New Paradigm of The In Situ Polymerization Technology Inside Lithium Batteries
Authors: Zhang Shenghang , Xie Bin , Zhuang Xiangchun , Wang Shitao , Qiao Lixin , Dong Shanmu , Ma Jun , Zhou Qian , Zhang Huanrui , Zhang Jianjun , Ju Jiangwei , Xu Gaojie , Cui Zili , Cui Guanglei 
Published: December 2023

AbstractIn situ polymerization technology is expected to empower the next generation high specific energy lithium batteries with high safety and excellent cycling performance. Nevertheless, the large‐scale commercial applications of most reported in situ polymer electrolytes are still full of challenges. Owing to the severe parasitic reactions caused by residual monomers, additional initiators and oligomers, lithium batteries using in situ polymer electrolytes often demonstrate limited specific capacity, poor cycling performance, and insufficient rate capability. However, this issue has not received adequate attention in previous reports. Furthermore, the design and evaluation of in situ polymer electrolytes still lack effective guidance and unified standards. Herein, the development history of in situ polymer electrolytes are systematically reviewed and critically disclose the great challenges. Then, from the aspects of monomers, initiators, separators, manufacturing technologies, safety and cycle life evaluation, unprecedentedly a new paradigm is provided for upgrading the in situ polymerization technology inside lithium batteries. It is hoped the novel paradigm will prompt much more insightful studies, expediting the commercialization of in situ polymerization technology in lithium batteries.
A Stretchable and Strain‐Limiting, Bio‐Inspired Nanofiber‐Reinforced Microfiber for Wearable Electronics
Authors: Hanif Adeela , Park Junho , Kim Dohui , Youn Jaeseung , Jeong Unyong , Kim Dong Sung 
Published: December 2023

AbstractWith existing fiber‐based approaches for wearable electronics, devices with limited stretchability are not fully protected against large stretching when the wearer is participating in vigorous activities. A network of elastin and collagen fibers makes biological tissues elastic at low strains and strain‐limiting at high strains, showing a J‐shaped stress‐strain behavior. Stretchable systems can replicate a “J‐shaped stress‐strain/strain‐limiting” mechanical behavior of biological tissues under deformations and provide mechanical compliance and comfort to wearers. For mimicking this mechanical behavior of biological tissues, he developed a combined microfiber and nanofiber (NF)‐based approach. The soft polyurethane (PU) microfiber mimicking elastin of biological tissue is wrapped with stiff poly(vinylidene fluoride)(PVDF) NFs, mimicking collagen in tissue, and dip coated in polydimethylsiloxane (PDMS). Confocal images during stretching confirmed that the PU microfiber maintained stretchability, while the stiff PVDF NFs played a role in the strain‐limiting characteristics. By tailoring a loading ratio of the PVDF NFs on the PU microfiber, the elastic modulus is matched well with those of biological tissues. The stretchable conducting coating and temperature sensor on the bio‐inspired microfiber showed a negligible difference in a current‐time (I‐T) response during static and dynamic stretching which indicated the efficient absorption of stress by the bio‐inspired microfiber.
Biomimetic Small Intestinal Peristalsis Simulator Using Circumferential Pneumatic Artificial Muscles (cirPAM)
Authors: Peerlinck Sam , Willemyns Frauke , Reynaerts Dominiek , Gorissen Benjamin 
Published: December 2023

AbstractSurgical simulators offer clinicians an environment to train techniques before transitioning to on‐patient procedures. The realism with which a certain procedure can be mimicked is limited by the used simulator model. While for certain procedures surgical simulators are well established, other procedures lack a sufficiently realistic hardware model. The field of soft robotics is especially suited to act as a platform for developing soft tissue surgical simulators, matching both stiffness and extent of deformation of biological soft tissue. Here, an integrated, pneumatically actuated intestinal peristalsis simulator is developed that mimics a section of the small intestines. This simulator is able the mimic both the peristalsis functionality and the intestinal morphology. The simulator incorporates novel circumferential pneumatic artificial muscles (cirPAM) that radially contract and expand when exposed to respectively negative and positive pressures while keeping their cross‐sectional thickness constant. By sequencing the inflation of these cirPAM actuators, a global peristaltic motion is created with a peristaltic wave propagating at 20 mm s −1, which is in accordance with human physiology. Finally, the simulator is shown to pump viscous liquids, confirming that besides the morphological semblance, it also functionally resembles human small intestine, and can offer a platform for medical device testing and surgical training.
Tolerant and Rapid Endochondral Bone Regeneration Using Framework‐Enhanced 3D Biomineralized Matrix Hydrogels
Authors: Bai Baoshuai , Liu Yanhan , Huang Jinyi , Wang Sinan , Chen Hongying , Huo Yingying , Zhou Hengxing , Liu Yu , Feng Shiqing , Zhou Guangdong , Hua Yujie 
Published: December 2023

AbstractTissue‐engineered bone has emerged as a promising alternative for bone defect repair due to the advantages of regenerative bone healing and physiological functional reconstruction. However, there is very limited breakthrough in achieving favorable bone regeneration due to the harsh osteogenic microenvironment after bone injury, especially the avascular and hypoxic conditions. Inspired by the bone developmental mode of endochondral ossification, a novel strategy is proposed for tolerant and rapid endochondral bone regeneration using framework‐enhanced 3D biomineralized matrix hydrogels. First, it is meticulously designed 3D biomimetic hydrogels with both hypoxic and osteoinductive microenvironment, and then integrated 3D‐printed polycaprolactone framework to improve their mechanical strength and structural fidelity. The inherent hypoxic 3D matrix microenvironment effectively activates bone marrow mesenchymal stem cells self‐regulation for early‐stage chondrogenesis via TGFβ/Smad signaling pathway due to the obstacle of aerobic respiration. Meanwhile, the strong biomineralized microenvironment, created by a hybrid formulation of native‐constitute osteogenic inorganic salts, can synergistically regulate both bone mineralization and osteoclastic differentiation, and thus accelerate the late‐stage bone maturation. Furthermore, both in vivo ectopic osteogenesis and in situ skull defect repair successfully verified the high efficiency and mechanical maintenance of endochondral bone regeneration mode, which offers a promising treatment for craniofacial bone defect repair.
Crystallography of Active Particles Defining Battery Electrochemistry
Authors: Morley John Donald , George Chandramohan , Hadler Kathryn , Brito‐Parada Pablo R. 
Published: December 2023

AbstractCrystallographic features of battery active particles impose an inherent limitation on their electrochemical figures of merit namely capacity, roundtrip efficiency, longevity, safety, and recyclability. Therefore, crystallographic properties of these particles are increasingly measured not only to clarify the principal pathways by which they store and release charge but to realize the full potential of batteries. Here, state‐of‐the‐art advances in Li+, K+, and Na+ chemistries are reviewed to reiterate the links between crystallography variations and battery electrochemical trends. These manifest at different length scales and are accompanied by a multiplicity of processes such as doping, cation disorder, directional crystal growth and extra redox. In light of this, an emphasis is placed on the need for more accurate correlations between crystallographic structure and battery electrochemistry in order to harness crystallographic beneficiation into electrode material design and manufacture, translating into high‐performance and safe energy storage solutions.
Organocatalytic Chemoselective C4‐Benzylation of 5‐Aminopyrazoles
Authors: Natarajan Pradeep , Kanchithalaivan Selvaraj , Chatterjee Arpita , Peruncheralathan Saravanan 
Published: December 2023

AbstractThe first chemoselective C4‐benzylation of 5‐aminopyrazoles, utilizing a 3 mol% squaric acid catalyst, is disclosed. In this process, ortho‐quinone methides are efficiently generated from 2‐hydroxybenzyl alcohols in water under mild conditions. This method successfully delivers a wide range of C4‐benzylated 5‐aminopyrazoles, achieving moderate to excellent yields while demonstrating high chemoselectivity, which is further confirmed by mechanistic studies. Notably, the protocol uses water as an eco‐friendly solvent, requires a low organocatalyst loading, and eliminates the need for column chromatography.
Cell‐Penetrating Peptide‐Bismuth Bicycles**
Authors: Voss Saan , Adair Liam D. , Achazi Katharina , Kim Heeyoung , Bergemann Silke , Bartenschlager Ralf , New Elizabeth J. , Rademann Jörg , Nitsche Christoph 
Published: December 2023

AbstractCell‐penetrating peptides (CPPs) play a significant role in the delivery of cargos into human cells. We report the first CPPs based on peptide‐bismuth bicycles, which can be readily obtained from commercially available peptide precursors, making them accessible for a wide range of applications. These CPPs enter human cells as demonstrated by live‐cell confocal microscopy using fluorescently labelled peptides. We report efficient sequences that demonstrate increased cellular uptake compared to conventional CPPs like the TAT peptide (derived from the transactivating transcriptional activator of human immunodeficiency virus 1) or octaarginine (R8), despite requiring only three positive charges. Bicyclization triggered by the presence of bismuth(III) increases cellular uptake by more than one order of magnitude. Through the analysis of cell lysates using inductive coupled plasma mass spectrometry (ICP‐MS), we have introduced an alternative approach to examine the cellular uptake of CPPs. This has allowed us to confirm the presence of bismuth in cells after exposure to our CPPs. Mechanistic studies indicated an energy‐dependent endocytic cellular uptake sensitive to inhibition by rottlerin, most likely involving macropinocytosis.
The use of xylose from elephant grass liquor and coproduction of organic acids by wild‐type bacteria isolated from food waste
Authors: Menegussi Elisa Bellan , Montipó Sheila , Fontana Roselei Claudete , Paesi Suelen , Camassola Marli 
Published: December 2023

AbstractDuring the normal production of ethanol from pretreated lignocellulosic biomass, only the solid fraction containing C6 sugars is generally used by unmodified yeasts in the fermentation process – the remaining liquid fraction, rich in xylose, is used almost exclusively by genetically modified organisms (GMOs) or for other purposes. As the liquor can be used in the manufacture of a series of chemical inputs, microorganisms that metabolize C5 sugars from different sources were initially isolated with the aim of converting these sugars into acetic acid (AA) and lactic acid (LA). Experiments were carried out with pretreated elephant grass liquor, evaluating the effect of adding commonly referenced nutrients through experimental design. Thus, the present work involves the isolation, screening, and molecular characterization of bacteria, easily found in nature, with the potential to metabolize xylose and produce AA and LA, with yields similar or superior to those shown in studies employing GMOs. Using wild‐type strains, high yields were obtained with Acetobacter cerevisiae (0.96 g LA and 0.71 g AA per g total sugars) and Levilactobacillus brevis (0.77 g LA and 0.61 g AA per g total sugars) in relation to the organic acids of interest, highlighting the total conversion of the sugar blend (xylose, glucose, and arabinose) in 24 h. Ammonium citrate also significantly influenced the final yields, being responsible for the increase in production. The results are useful for biorefinery platforms and may contribute to the full use of sugars released in the lignocellulosic pretreatment of raw materials.
Complicated atopic dermatitis in a healthy infant: Homemade walnut cream
Authors: Abtahi‐Naeini Bahareh , Emadoleslami Monir Sadat , Pourmahdi‐Boroujeni Mahsa , Bahrami‐Samani Farnaz 
Published: December 2023

Key Clinical MessageHealthcare providers should educate patients on the appropriate use of topical agents and the potential risks associated with non‐standardized formulations, especially for infants and young children.AbstractComplementary and alternative medicine (CAM) is an unconventional treatment method used alongside or in addition to conventional medical treatment methods to improve the healing process. Inappropriate administration of CAM can worsen the condition of diseases and have potential hazards for patients. Herbal therapy is one of the most famous and widely used CAMs in treating various skin disorders. In this case, we report a 4‐month‐old girl with atopic dermatitis who demonstrates ulceronecrotic lesions on her face and extremities besides sepsis 3 days after a walnut's homemade cream consumption. She was treated with intravenous clindamycin and wet‐to‐dry dressing to remove the scabs. This case report shows the potentially hazardous effects of misused traditional and homemade herbal therapy. It highlighted the need to pay particular attention when CAMs are used, especially for infants and young children.
To cool or not to cool: Targeted temperature management to prevent ventricular tachycardia associated with Brugada syndrome
Authors: Kiefer Nicholas J. , Ahuja Tania , Caballero Alexandra , Pashun Raymond Anthony 
Published: December 2023

Key Clinical MessageA robust inflammatory and febrile response from acute viral illness such as with SARS‐CoV‐2 in patients with Brugada syndrome may lead to triggering of ventricular arrhythmias. The use of targeted temperature management (TTM) using cooling devices may mitigate the febrile triggering of ventricular arrhythmias in patients with Brugada syndrome.AbstractBrugada syndrome (BrS) is an autosomonal dominant genetic disorder, with a risk of ventricular tachycardia (VT). Triggers of VT in BrS include fevers. Here, we report a case of BrS secondary to SARSs‐CoV‐2 infection and the use of targeted temperature management (TTM) to decrease fever and prevent VT triggering.
Suspected case of benign familial fleck retina with functional loss
Authors: Constable Paul A. , Loh Lynne , Grigg John R. 
Published: December 2023

Key Clinical MessageInherited retinal dystrophies typically affect vision in early childhood; however, this case highlights a late onset retinal dystrophy presenting in midlife and the need for extended visual electrophysiology testing to determine the etiology.AbstractA 53‐year‐old female was referred for visual electrophysiology following a routine optometric eye examination in which yellow flecks were noted in both fundi and the patient had reported a recent near accident whilst driving at night. There was no reported family history of eye disease. Retinal examination identified bilateral yellow punctate and irregularly shaped lesions throughout the posterior poles sparing the macula region. Fundus autofluorescence showed coinciding hyperfluorescence with the lesions and bilateral hypofluorescent crescents superior to the macular with corresponding retinal thinning. Visual fields and color vision were normal. ISCEV standard 20 min and extended 60‐min dark adapted electroretinograms were recorded. Recovery to normal b‐wave amplitudes was noted in the DA0.01 flash but reduced a‐wave amplitudes were noted in the DA3 and DA10 flash following both dark adapted periods. Cone function was reduced but within normal limits. Genetic screening revealed a previously unreported variant of unknown significance in the gene PLA2G5:c.40 + 5del (rs1364254561) which is a member of the phospholipase A2 family and is associated with familial benign flecked retina.
Nontuberculous mycobacterial abscess of lacrimal sac and eyelid debridement: Case report
Authors: Matsuo Toshihiko , Tanaka Takehiro , Yamada Kiyoshi , Nose Motoko , Tanimoto Yasushi 
Published: December 2023

Key Clinical MessageIt is important to stain acid‐fact bacilli on the smear of abscess puncture in addition to Gram stain to detect nontuberculous and tuberculous mycobacteria in the early phase since both can cause rare and challenging extrapulmonary manifestations.AbstractA 56‐year‐old otherwise healthy woman developed abscess from dacryocystitis in the right lower eyelid. The smear of puncture fluid showed acid‐fast bacilli and Mycobacterium abscessus was identified after a month. The early start of clarithromycin/ethambutol was switched to clarithromycin/levofloxacin. Debridement specimen after 7‐month treatment showed granulomatous tissue with no bacilli.
A rare case of tumefactive demyelination of brain: A case report and literature review
Authors: Inban Pugazhendi , Akuma Ogbonnaya , Elavia Zenia , Akuma Chinaza Mercy , Singh Mansi , Kachhadia Meet Popatbhai , Musiime Agaba Barnett James 
Published: December 2023

AbstractThis case report highlights the diagnostic challenges encountered in a 30‐year‐old female presenting with fever followed by Wernicke's aphasia without right‐sided weakness, ultimately diagnosed as tumefactive demyelination (TD). TD is a rare neurological condition often misidentified as brain tumors or inflammatory disorders. The case emphasizes the importance of precise differentiation through advanced magnetic resonance imaging, showing restricted diffusion at lesion edges and the absence of gadolinium enhancement. Accurate diagnosis is crucial for tailored treatment and prognostic assessment. This case contributes to our understanding of TD and underscores the need for continued research and collaboration in the field of rare neurological disorders.
Computational Assistance in the Design of Efficient Oxygen Reduction Reaction Electrocatalysts
Authors: Qi Chunhong , Qiu Pengpeng , Luo Wei 
Published: December 2023

AbstractRecently, theoretical calculations have played an irreplaceable role in the discovery of electrocatalysts as a relatively time‐efficient, cost‐effective, and predictable method. More importantly, theoretical calculations can help screen out the best active reaction sites and modulate them accordingly, which is beneficial for the development of efficient catalysts. In this concept, we focus on the important role of theoretical calculations in determining catalytic active sites and understanding reaction mechanisms, emphasizing its importance in assisting the design and synthesis of efficient oxygen reduction reaction catalysts. Finally, we provide an outlook on the challenges and future development trend in this field.
The Effect of Size and Morphology on the Antibacterial Activity of Zn‐loaded LTL Nanozeolite
Authors: Salek Gilani Neda , Tilami Salma Ehsani , Ahghari Mohammad Reza , Azizi Seyed Naser , Hosseinkhani Saman 
Published: December 2023

AbstractA simple and cost‐effective approach was used to synthesize different morphologies of Linde Type L (LTL) nanozeolite. The resulting products were characterized by techniques such as X‐ray diffraction, Fourier transform infrared spectroscopy, scanning electronic microscopy, and Brunauer‐Emmett‐Teller measurements. The results showed that LTL nanozeolite was successfully synthesized, and different morphologies, including spherical‐like and disk‐shaped nanoparticles, were obtained. Then, the effect of size and morphology on the antibacterial activity of the obtained products was studied. Spherical‐like LTL nanoparticles showed higher antibacterial activity due to their larger pore volume and surface area and higher loading of biocidal zinc cations.