bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Assembled nanoparticles of natural bioactive molecules enhance the delivery and efficacy of paclitaxel in glioblastoma
Authors: Li Yong , Zhao Qingyu , Zhu Xinyi , Zhou Long , Song Ping , Liu Baohui , Tian Daofeng , Chen Qianxue , Zhou Jiangbing , Deng Gang 
Published: December 2023

AbstractBackgroundGlioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Paclitaxel (PTX) is a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, the application of PTX in GBM is hindered by several limitations, including poor water solubility, restricted entry across the blood–brain barrier (BBB), and enhanced excretion by efflux transporters. P‐glycoprotein (P‐gp) is a crucial efflux transporter that is abundantly present in cerebral vascular endothelial cells and GBM cells. It plays a significant role in the exocytosis of PTX within tumor tissues.MethodsRecently, we have developed a novel technique for creating self‐assembled nanoparticles utilizing a range of natural bioactive molecules. These nanoparticles can encapsulate insoluble drugs and effectively cross the BBB. In additional, we revealed that certain nanoparticles have the potential to act as P‐gp inhibitors, thereby reducing the excretion of PTX. In this study, we conducted a screening of bioactive molecular nanoparticles to identify those that effectively inhibit the function of P‐gp transporters.ResultsAmong the candidates, we identified ursolic acid nanoparticles (UA NPs) as the P‐gp inhibitors. Furthermore, we prepared co‐assembled UA NPs embedded with paclitaxel, referred to as UA‐PTX NPs. Our results demonstrate that UA‐PTX NPs can enhance the blood concentration of PTX, facilitate its entry into the BBB, and inhibit the function of P‐gp, resulting in a decrease in the excretion of PTX. This discovery effectively addressed the above three issues associated with the use of PTX in glioma treatment.ConclusionsUA‐PTX NPs demonstrate strong anti‐tumor effects and show great potential for treating GBM.
Characteristics of high‐ and low‐risk drinkers who use online alcohol home delivery in Western Australia
Authors: Coomber Kerri , Baldwin Ryan , Taylor Nicholas , Callinan Sarah , Wilkinson Claire , Toumbourou John W. , Chikritzhs Tanya , Miller Peter G. 
Published: December 2023

AbstractIntroductionVariation in alcohol availability is an important driver of levels of consumption and harm, with recent increases in online alcohol home delivery use expanding availability. There is limited research on the impacts of these changes and the characteristics of consumers who use alcohol home delivery.MethodsThis study presents findings from an online survey (n = 465) of Western Australian adults who had purchased alcohol for home delivery within the past 6 months. Analyses compared high‐risk and low‐risk drinkers on use of, and exposure to, alcohol home delivery.ResultsCompared to low‐risk drinkers, high‐risk drinkers were significantly more likely to make more frequent online purchases (odds ratio 5.42), utilise same day delivery (odds ratio 2.91) and purchase through specialised online‐only retailers (odds ratio 2.69). High‐risk drinkers also reported receiving deliveries while intoxicated more often (odds ratio 11.62), and ordering alcohol for delivery to continue a current drinking session (odds ratio 7.47). High‐risk drinkers also received advertising for alcohol home delivery more frequently (odds ratio 1.60) than low‐risk drinkers. High‐risk drinkers also ordered larger quantities of alcohol than low‐risk drinkers (M = 49 vs. 32 standard drinks).Discussion and ConclusionsFindings from this study indicate that these services are popular with high‐risk drinkers and potentially undermine other policy efforts to reduce drinking. Within Australia, stronger legislation (such as mandatory delay between order and delivery) and monitoring (e.g., test purchasing for compliance) are recommended.
Intimate partner violence screening for separating or divorcing parents: An introduction to the Mediator's Assessment of Safety Issues and Concerns‐Short (MASIC‐S)
Authors: Rossi Fernanda S. , Applegate Amy G. , Tomlinson Claire , Holtzworth‐Munroe Amy 
Published: December 2023

AbstractIntimate partner violence (IPV) is a leading cause of separation and/or divorce. IPV may not stop after separation, as parents who use IPV can continue intruding in the lives of parents who experience IPV due to unsafe parenting arrangements that allow continued frequent contact and thus risk further abuse. Therefore, it is critical that separating/divorcing parents be assessed for IPV and ongoing safety concerns. Parenting arrangements (e.g., physical and legal custody, parenting time) may not include the appropriate protections if IPV has not been uncovered and/or considered. Unfortunately, many existing IPV screens for family court processes have limitations. The Mediator's Assessment of Safety Issues and Concerns‐Short (MASIC‐S) was designed to address these limitations. Results from the MASIC‐S may be used to inform and create parenting arrangements in the best interest of the child. We provide recommendations on how MASIC‐S results can guide family court practitioners in parenting arrangement disputes. These recommendations are based on the existing literature and guidelines regarding the relationship between parenting arrangements and child‐wellbeing following separation/divorce in the context of IPV. We also discuss areas in which additional research is needed to help determine parenting arrangements most suitable for separating/divorcing parents with a history of IPV.
Trans‐aortic mitral isthmus ablation after surgical patch closure for an atrial septal defect
Authors: Arai Tomoyuki , Kujiraoka Hirofumi , Yamaoka Koichiro , Takahashi Masao , Hojo Rintaro , Fukamizu Seiji 
Published: December 2023

AbstractIntroductionIn patients with prior atrial septal defect (ASD) closure and atrial tachyarrhythmias, transseptal puncture can be challenging.Methods and ResultsThis case report discusses a 65‐year‐old man who had previously undergone pulmonary vein isolation (PVI) and cavo‐tricuspid isthmus ablation for atrial fibrillation before ASD closure, respectively. He developed atrial tachycardia (AT) and underwent catheter ablation. AT was diagnosed as peri‐mitral flutter and the mitral isthmus (MI) linear ablation via a trans‐aortic approach successfully terminated it.ConclusionThis case demonstrates the feasibility and safety of transaortic MI linear ablation in patients with ASD closure devices or anatomical challenges when transseptal puncture is difficult.
Decision curve analysis based on summary data
Authors: Hozo Iztok , Guyatt Gordon , Djulbegovic Benjamin 
Published: December 2023

AbstractBackgroundTo realize the potential of precision medicine, predictive models should be integrated within the framework of decision analysis, such as the decision curve analysis (DCA). To date, its application has required individual patient data (IPD) that are often unavailable. Performing DCA using aggregate data without requiring IPD may advance the goals of precision medicine.MethodsWe present a statistical framework demonstrating that DCA can be conducted by using only the mean and standard deviation (SD) from the raw probabilities of the predictive model. We tested our theoretical framework by performing extensive simulations and comparing the aggregate‐based DCA with IPD DCA. The latter was conducted using IPD from four predictive models that employed logistic regression, Cox or competing risk time‐to‐event modeling including (a) statins for primary prevention of cardiovascular disease (n = 4859), (b) hospice referral for terminally ill patients (n = 9104), (c) use of thromboprophylaxis for preventing venous thromboembolism in patients with cancer (n = 425) and (d) prevention of sinusoidal obstruction syndrome after hematopoietic cell transplantation (SCT) (n = 80).ResultsSimulations assuming perfect calibration showed that regardless of which probability distributions informed the predictive models, the differences in DCA were negligible. Similarly, for the adequately powered models, the results of DCA based on the summary data were similar to IPD‐derived DCA. The inherent instability of the predictive models, based on the smaller sample sizes, resulted in a somewhat larger discrepancy between aggregate and IPD‐based DCA.ConclusionsDCA informed by adequately powered and well‐calibrated models using only summary statistical estimates (mean and SD) approximates well models using IPD. Use of aggregate data will facilitate broader integration of predictive with decision modeling toward the goals of individualized decision‐making.
Foam‐mat‐dried açaí pulp (Euterpe oleracea Mart)
Authors: Ferreira Diene de Barros , Gandin Yuri Eduardo Mendes , de Morais Ana Flavia Carla , Pinto Vania Zanella , Quast Leda Battestin 
Published: December 2023

AbstractDrying, as alternative process, enhances stability, eases transport, and prolongs storage for fruits and fruit pulps. This study focused on producing açaí foam with 2% emulsifier and comparing it to a control (0% emulsifier), following by drying (60 °C) in a forced air circulation oven. Açaí powder with 2% emulsifier exhibited a higher effective diffusion coefficient (5.35  ×  10−4 cm2 s−1) than the without emulsifier counter part (1.41  ×  10−4 cm2 s−1). The pores formed after pulp aeration with the emulsifying agent led to a higher diffusion coefficient and a shorter drying time. Sorption isotherms at 25 °C and 35 °C displayed favorable fits for both powders (R2>0.9). Açaí powder with emulsifier demonstrated superior solubility (47.93%) and faster rehydration (168 s) compared to the control (19.72%; 324 s). The use of a 2% emulsifying agent resulted in a porous, dried açaí powder with improved flowability and solubility, indicating higher quality.Practical applicationsTraditionally, açai pulp is commercialized as a frozen product, which entails high energy costs and logistical constraints. Foam‐mat drying allows the dehydration of viscous, heat‐sensitive, and high‐sugar foods that cannot be effectively dried through spray drying. It offers a practical application in the food industry, particularly as an ingredient. Powdered fruit pulps, including açai pulp, are widely utilized in ice creams, yogurts, and instant juices. To meet industrial requirements, these powders need to exhibit good solubility, quick rehydration, and stability at room temperature. Through foam‐mat drying, high‐quality powdered açai pulp can be produced with a short drying time. This technology enables the production of stable powders that can be easily rehydrated, opening opportunities for new ingredient development and diverse applications.
Stability of antimicrobial, antioxidant, and functional properties of pectin‐based film incorporated with Thymus capitatus and Cinnamomum verum essential oils
Authors: Khachani Raoya , El Galiou Ouiam , Aitboulahsen Mohammed , Bakrim Hanane , Arakrak Abdelhay , Laglaoui Amin , Hassani Zerrouk Mounir 
Published: December 2023

AbstractBiopolymer‐based films present numerous environmental advantages. The current study aims to investigate the impact of storage time on the antimicrobial, antioxidant, and functional properties of pectin‐based films containing Thymus capitatus (TEO) and Cinnamomum verum (CEO) essential oils (EOs). Films were prepared using the solution casting method; their different properties were evaluated over 1 month at room temperature. Both types of films displayed strong antimicrobial activity against Staphylococcus aureus (S. aureus), Listeria monocytogenes (L. monocytogenes), Escherichia coli (E. coli), and Salmonella typhimurium (S. typhimurium). Pectin‐based film incorporated with CEO displayed greater antioxidant activity than film incorporated with TEO. The two EOS increased the films' elongation at break and tensile strength. However, their moisture content and thickness decreased. The antibacterial and antioxidant activities of the CEO‐ and TEO‐based films decreased after 4 weeks of storage, while moisture content increased. However, the films' mechanical parameters remained stable during the entire storage period.
Unlocking the potential of the bioeconomy for climate change reduction: The optimal use of lignocellulosic biomass in Germany
Authors: Lubjuhn Sebastian , Venghaus Sandra 
Published: December 2023

AbstractThe concept of a circular bioeconomy has become a new economic leitmotif for reducing greenhouse gas (GHG) emissions. Its central narrative rests on the idea of replacing fossil resources with biobased ones for a broad spectrum of products including, for example, heat, electricity, fuels, plastics, or chemicals. Yet, the amount of available bio‐resources is limited, rendering some technologies successful while leaving behind others. Lignocellulosic biomass (LBM) is a key resource already used on a large scale for heating purposes or electricity production and increasingly for the production of chemicals and biofuels. Because market mechanisms do not necessarily drive a cost‐optimal use with respect to their GHG‐reduction potential, a new bi‐objective linear optimization model under long‐term scenarios was developed for Germany accounting for competition with non‐biobased technologies. In the biofuels and biochemicals sectors, multi‐output processes that address industrial symbiosis and fossil references are used to compute profits and GHG emission savings of biobased products. However, in the absence of a reference for heat, a detailed representation of the heat sector is used in which heat demand for 19 subsectors is met, thus deriving costs and emission savings endogenously. When explicitly accounting for GHG emission reduction targets, biomass is optimally used in high‐temperature industries whereas heat pumps dominate in building heat. Because of the optimal use of biomass in industrial usage, subsidies for biomass heating are found to be inefficient in the building sector. Catalytic hydropyrolysis to produce biogasoline and biodiesel using LBM dominates the production of biofuels while biochemicals—strongly depending on oil price developments—will become competitive on a large scale after 2030.
Factors associated with the oral health status of patients with schizophrenia: A cross‐sectional study
Authors: Matsubara Chiaki , Yamaguchi Kohei , Imada Ryoko , Yoshizawa Akira , Bando Yasuko , Kusaka Teruo , Furuya Junichi , Tohara Haruka 
Published: December 2023

AbstractBackgroundOral function deterioration attributed to ageing and medications is one of the main contributory factors of dysphagia. Therefore, oral health management is essential in older patients with schizophrenia. However, no previous studies have evaluated the oral function in patients with schizophrenia.ObjectiveWe surveyed patients with schizophrenia to identify factors associated with ageing‐related variations in oral function.MethodsThis cross‐sectional study included 34 male patients diagnosed with schizophrenia who were hospitalised at a psychiatric hospital between July and September 2021 and underwent a screening examination during dental care. The survey items included basic information, oral hygiene information, oral (oral diadochokinesis [ODK] and tongue pressure), physical function, and nutritional status. Thirty‐six male community‐dwelling older individuals were included as controls, and their outcomes were compared with those of patients with schizophrenia.ResultsCompared with healthy older adults, patients with schizophrenia demonstrated significantly lower teeth numbers, ODK, and calf circumference (CC) (p < .05). Multiple regression analysis revealed that ODK was associated with age and schizophrenia (p < .05). Conversely, tongue pressure was associated with CC (p < .05), suggesting different factors' association with the parameters indicating decreased oral function.ConclusionsOur study findings suggest that older patients with schizophrenia have decreased tongue pressure and generalised muscle mass, highlighting the need to manage oral function. Interventions for tongue pressure were more strongly associated with muscle mass and could be easier to manage than those with disease‐dependent changes in ODK.Trial RegistrationRetrospectively registered.
A spatiotemporal control method at isolated intersections under mixed‐autonomy traffic conditions
Authors: Dai Rongjian , Ding Chuan , Yu Bin , Hu Jia 
Published: December 2023

AbstractWith the introduction of connected and automated vehicles (CAVs), the integrated control of traffic signals, lane assignments, and vehicle trajectories becomes feasible, offering notable benefits for enhancing intersection operations. However, during the prolonged transition to an entirely CAV environment, how to fully leverage the advantage of CAVs while considering the characteristics of human‐driven vehicles remains a huge challenge. To address this challenge, this paper proposes a joint optimization method for spatiotemporal resources at isolated intersections under mixed‐autonomy traffic conditions. Initially, the lane assignment optimization problem is modeled as a mixed integer linear program model to maximize the reserve capacity. Subsequently, the signal‐vehicle coupled control is formulated as a dynamic programming model with the objective of reducing vehicle travel time. Additionally, criteria are established to assess the need for re‐optimizing lane assignments. Simulations validate the superiority of the proposed control method over adaptive control in terms of traffic efficiency and intersection capacity amid substantial traffic demand fluctuations. Sensitivity analyses reveal that the proposed control method can yield higher benefits under medium traffic demand levels. Furthermore, the proposed algorithm exhibits no significant sensitivity to the CAV market adoption rate, suggesting its applicability throughout the CAV adoption process.
Ferroptosis induced by plasma‐activated Ringer's lactate solution prevents oral cancer progression
Authors: Sato Kotaro , Yang Ming , Nakamura Kae , Tanaka Hiromasa , Hori Masaru , Nishio Miki , Suzuki Akira , Hibi Hideharu , Toyokuni Shinya 
Published: December 2023

AbstractObjectiveThis study aimed to investigate the effect of plasma‐activated Ringer's lactate solution (PAL) on oral squamous cell carcinoma (OSCC) cells and carcinogenic processes with a particular focus on iron and collagenous matrix formation.Materials and MethodsWe used three OSCC cell lines, one keratinocyte cell line, and two fibroblast lines, and cell viability assays, immunoblotting, flow cytometry, and transmission electron microscopy were performed to evaluate the effect and type of cell death. The effect of PAL treatment on lysyl oxidase (LOX) expression was investigated in vitro and in vivo. Tamoxifen‐inducible Mob1a/b double‐knockout mice were used for the in vivo experiment.ResultsPAL killed OSCC cells more effectively than the control nontumorous cells and suppressed cell migration and invasion. Ferroptosis occurred and the protein level of LOX was downregulated in cancer cells in vitro and in vivo. Additionally, PAL improved the survival rate of mice and suppressed collagenous matrix formation.ConclusionsWe demonstrated that PAL specifically kills OSCC cells and that ferroptosis occurs in vitro and in vivo. Furthermore, PAL can prevent carcinogenesis and improve the survival rate of oral cancer, especially tongue cancer, by changing collagenous matrix formation via LOX suppression.
Ozonized gels vs chlorhexidine in non‐surgical periodontal treatment: A randomized clinical trial
Authors: Scribante Andrea , Gallo Simone , Pascadopoli Maurizio , Frani Monica , Butera Andrea 
Published: December 2023

AbstractObjectiveTo evaluate the efficacy of newly introduced ozonated gels compared with conventional chlorhexidine gel in the home management of periodontal patients.Materials and Methods30 patients with bilateral periodontal disease (severity I, complexity II) were enrolled (split‐mouth study design). After nonsurgical mechanical periodontal debridement, the teeth were randomly divided into two groups: teeth in the Control group were treated with a chlorhexidine‐based gel to aid oral hygiene maneuvers for 2 weeks after the first visit, while teeth in the Test group were treated in the same way with ozone‐based gels. After the baseline assessment, the follow‐up included assessments at 1, 2, and 6 months. The variables evaluated were clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BoP), plaque control record (PCR), recession (R), and tooth mobility (TM).ResultsFor CAL, PPD, BoP, and PCR, significant intragroup differences were found for both groups (p < 0.05), in contrast to intergroup differences (p > 0.05). No significant differences were found for R and TM.ConclusionNonsurgical mechanical periodontal debridement with adjunctive use of ozone and chlorhexidine was found to be effective in periodontal treatment. Ozone could be suggested as an alternative to chlorhexidine.
Development and Validation of a Risk‐Prediction Nomogram for Preoperative Blood Type and Antibody Testing in Spinal Fusion Surgery
Authors: Wu Linghong , Peng Xiaozhong , Zhuo Xianglong , Zhu Guangwei , Xie Xiangtao 
Published: December 2023

ObjectiveWith advancements in minimally invasive techniques, the use of spinal fusion surgery is rapidly increasing and transfusion rates are decreasing. Routine preoperative ABO/Rh blood type and antibody screening (T&S) laboratory tests may not be appropriate for all spinal fusion patients. Herein, we constructed a nomogram to assess patient transfusion risk based on various risk factors in patients undergoing spinal fusion surgery, so that preoperative T&S testing can be selectively scheduled in appropriate patients to reduce healthcare and patient costs.MethodsPatients who underwent spinal fusion surgery between 01/2020 and 03/2023 were retrospectively examined and classified into the training (n = 3533, 70%) and validation (n = 1515, 30%) datasets. LASSO and multivariable logistic regression were used to analyze risk factors for blood transfusion. Nomogram predictive model was built according to the independent predictors and mode predictive power was validated using consistency index (C‐index), Hosmer–Lemeshow (HL) test, calibration curve analysis and area under the curve (AUC) for receiver operating characteristic (ROC) curve. Bootstrap resampling was used for internal validation. Decision curve analysis (DCA) was applied to evaluate the model's performance in the clinic.ResultsBeing female, age, BMI, admission route, critical patient, operative time, heart failure, end‐stage renal disease or chronic kidney disease (ESRD or CKD), anemia, and coagulation defect were predictors of blood transfusion for spinal fusion. A prediction nomogram was developed according to a multivariate model with good discriminatory power (C‐index = 0.887); Bootstrap resampling internal validation C‐index was 0.883. Calibration curves showed strong matching between the predicted and actual probabilities of the training and validation sets. HL tests for the training and validation sets had p‐values of 0.327 and 0.179, respectively, indicating good calibration. When applied to the training set, the following parameters were found: AUC: 0.895, 95% CI: 0.871–0.919, sensitivity 78.2%, specificity 86.7%, positive predictive value 29.4% and negative predictive value 98.2%. If the model were applied in the training set, 2911 T&S tests (82.4%) would be eliminated, equaling a RMB349,320 cost reduction. The AUC in the internal validation was: 0.879, 95% CI: 0.839–0.927, sensitivity 75.2%, specificity 88.8%, positive predictive value 34.3%, negative predictive value 97.9%, would eliminate 1276 T&S tests (84.2%), saving RMB 153,120. The DCA curve indicated good clinical application value.ConclusionThe nomogram based on 10 independent factors can help healthcare professionals predict the risk of transfusion for patients undergoing spinal fusion surgery to target preoperative T&S testing to appropriate patients and reduce healthcare costs.