bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomic feature reliability of amide proton transfer‐weighted MR images acquired with compressed sensing at 3 T
Authors: Wu Jingpu , Huang Qianqi , Shen Yiqing , Guo Pengfei , Zhou Jinyuan , Jiang Shanshan 
Published: January 2024

AbstractCompressed sensing (CS) is a novel technique for MRI acceleration. The purpose of this paper was to assess the effects of CS on the radiomic features extracted from amide proton transfer‐weighted (APTw) images. Brain tumor MRI data of 40 scans were studied. Standard images using sensitivity encoding (SENSE) with an acceleration factor (AF) of 2 were used as the gold standard, and APTw images using SENSE with CS (CS‐SENSE) with an AF of 4 were assessed. Regions of interest (ROIs), including normal tissue, edema, liquefactive necrosis, and tumor, were manually drawn, and the effects of CS‐SENSE on radiomics were assessed for each ROI category. An intraclass correlation coefficient (ICC) was first calculated for each feature extracted from APTw images with SENSE and CS‐SENSE for all ROIs. Different filters were applied to the original images, and the effects of these filters on the ICCs were further compared between APTw images with SENSE and CS‐SENSE. Feature deviations were also provided for a more comprehensive evaluation of the effects of CS‐SENSE on radiomic features. The ROI‐based comparison showed that most radiomic features extracted from CS‐SENSE‐APTw images and SENSE‐APTw images had moderate or greater reliabilities (ICC ≥ 0.5) for all four ROIs and all eight image sets with different filters. Tumor showed significantly higher ICCs than normal tissue, edema, and liquefactive necrosis. Compared to the original images, filters (such as Exponential or Square) may improve the reliability of radiomic features extracted from CS‐SENSE‐APTw and SENSE‐APTw images.
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin‐induced liver injury
Authors: Tanaka Saori , Noda Takumi , Urashima Kazuya , Ijiri Yoshio , Kohda Yuka , Kato Ryuji 
Published: January 2024

AbstractTrovafloxacin is a quinolone antibiotic drug with broad‐spectrum activity, which was withdrawn from a global market relatively soon after approval because of serious liver injury. The characteristics of trovafloxacin‐induced liver injury are consistent with an idiosyncratic reaction; however, the details of the mechanism have not been elucidated. We examined whether trovafloxacin induces the release of damage‐associated molecular patterns (DAMPs) that activate inflammasomes. We also tested ciprofloxacin, levofloxacin, gatifloxacin, and grepafloxacin for their ability to activate inflammasomes. Drug bioactivation was performed with human hepatocarcinoma functional liver cell‐4 (FLC‐4) cells, and THP‐1 cells (human monocyte cell line) were used for the detection of inflammasome activation. The supernatant from the incubation of trovafloxacin with FLC‐4 cells for 7 days increased caspase‐1 activity and production of IL‐1ß by THP‐1 cells. In the supernatant of FLC‐4 cells that had been incubated with trovafloxacin, heat shock protein (HSP) 40 was significantly increased. Addition of a cytochrome P450 inhibitor to the FLC‐4 cells prevented the release of HSP40 from the FLC‐4 cells and inflammasome activation in THP‐1 cells by the FLC‐4 supernatant. These results suggest that reactive metabolites of trovafloxacin can cause the release of DAMPs from hepatocytes that can activate inflammasomes. Inflammasome activation may be an important step in the activation of the immune system by trovafloxacin, which, in some patients, can cause immune‐related liver injury.
Assessing various CO2 utilization technologies: a brief comparative review
Authors: Turakulov Zafar , Kamolov Azizbek , Norkobilov Adham , Variny Miroslav , Díaz‐Sainz Guillermo , Gómez‐Coma Lucia , Fallanza Marcos 
Published: January 2024

AbstractCarbon dioxide (CO2) utilization technologies have emerged as a promising approach to address the direct and indirect consequences of climate change and the need for sustainable resource management. Those innovative technologies aim to capture and utilize CO2 by converting it into valuable products or directly using it as a chemical feedstock in various industries, thus, avoiding their release into the atmosphere. In this study, different CO2 utilization pathways including CO2 to chemicals and fuels, CO2 to building materials, CO2 to enhanced oil recovery (EOR), and CO2 to bio‐products are discussed in terms of their status – economic, environmental and technology readiness level performances. Moreover, various CO2 utilization pathways are comparatively analyzed considering their advantages and drawbacks, CO2 uptake potentials, and overall climate benefits. According to the comparison results, photocatalytic and electrochemical reduction of CO2 along with the bio‐fixation of CO2 are gaining more attention in the recent research and investigations, from the energy intensity and environmental point of view, whereas EOR remains dominant in terms of the scalability, maturity and economic benefits. However, limitations of EOR related to the capacity, life cycle and different geolocations, as well as the complexities of other mature approaches make room for emerging technologies to be more energy‐effective and environmentally friendly. Overall, most of the promising CO2 utilization techniques are either technologically immature or limited in scale to deploy globally. One of the main barriers to reusing CO2 is associated with the high cost of CO2‐based production and the low value of the CO2 market. © 2024 Society of Chemical Industry (SCI).
Adsorption and partition of the antibiotic ciprofloxacin in poultry litter
Authors: Effting Leticia Maria , Giona Renata Mello , Junior Ismael Laurindo Costa 
Published: January 2024

AbstractBACKGROUNDThe use of antibiotics on a large scale is a common practice in poultry farming. This research investigated the adsorption of the antibiotic ciprofloxacin (CIP) in poultry litter samples to assess the potential risk to ecosystems as a result of the compound mobility. This residue is used directly dispersed in agricultural soils as a biofertilizer.RESULTSExperimental data were evaluated in terms of fits of isotherm models. The mobility of CIP was assessed by the distribution coefficient and the partition coefficient related to organic matter. The studied poultry litter presented a pH of 8.5 ± 0.1, moisture content of 20.3 ± 1.3% and total solids content of 79.8 ± 1.2%, with a high amount of both inorganic matter (57.1 ± 1.7%) and organic matter (42.9 ± 1.7%) content in its composition. The Redlich–Petersen isotherm model satisfactorily described the experimental data, with higher maximum adsorption capacities at more alkaline pHs (pH 8.0 = 3015.0 ± 118.0 μg g−1, pH 7 = 2916.6 ± 1152.9 μg g−1 and pH 6 = 410.0 ± 18.1 μg g−1). The log Kd (pH 6 = 0.9, pH 7 = 1.2, and pH 8 = 1.4) and log Koc (pH 6 = 1.3, pH 7 = 1.7 and pH 8 = 1.8) values obtained for the sorption of ciprofloxacin at different pHs in poultry litter were considered low (log Koc < 3.5).CONCLUSIONSThe analyte does not tend to adsorb in the poultry litter and might leach to other environmental compartments. The information obtained in this study reinforces the ecotoxicological concern about antibiotic residues in the environment. © 2024 Society of Chemical Industry (SCI).
cGAS–STING‐mediated novel nonclassic antiviral activities
Authors: Hu Ying , Ye Runxin , Su Jiaming , Rui Yajuan , Yu Xiao‐Fang 
Published: January 2024

AbstractStimulatorof interferon genes (STING) is an intracellular sensor of cyclic dinucleotides involved in the innate immune response against pathogen‐ or self‐derived DNA. For years, interferon (IFN) induction of cyclic GMP–AMP synthase (cGAS)–STING has been considered as a canonical pattern defending the host from viral invasion. The mechanism of the cGAS–STING–IFN pathway has been well‐illustrated. However, other signalling cascades driven by cGAS–STING have emerged in recent years and some of them have been found to possess antiviral ability independent of IFN. Here, we summarize the current progress on cGAS–STING‐mediated nonclassic antiviral activities with an emphasis on the nuclear factor‐κB and autophagy pathways, which are the most‐studied pathways. In addition, we briefly present the primordial function of the cGAS–STING pathway in primitive species to show the importance of IFN‐unrelated antiviral activity from an evolutionary angle. Finally, we discuss open questions that need to be solved for further exploitation of this field.
Simulating the impact of optimized prevention and control measures on the transmission of monkeypox in the United States: A model‐based study
Authors: Cao Yawen , Fang Wenbin , Chen Yingying , Zhang Hengchuan , Ni Ruyu , Pan Guixia 
Published: January 2024

AbstractThis study aimed to develop a modified susceptible‐exposed–infected–recovered (SEIR) model to evaluate monkeypox epidemics in the United States and explore more optimized prevention and control measures. To further assess the impact of public health measures on the transmission of monkeypox, different intervention scenarios were developed based on the classic SEIR model, considering reducing contact, enhancing vaccination, diagnosis delay, and environmental transmission risk, respectively. We evaluated the impact of different measures by simulating their spread in different scenarios. During the simulation period, 8709 people were infected with monkeypox. The simulation analysis showed that: (1) the most effective measures to control monkeypox transmission during the early stage of the epidemic were reducing contact and enhancing vaccination, with cumulative infections at 51.20% and 41.90% of baseline levels, respectively; (2) shortening diagnosis time would delay the peak time of the epidemic by 96 days; and (3) the risk of environmental transmission of monkeypox virus was relatively low. This study indirectly proved the effectiveness of the prevention and control measures, such as reducing contact, enhancing vaccination, shortening diagnosis time, and low risk of environmental transmission, which also provided an important reference and containment experience for nonepidemic countries.
Strengthening Creative Problem‐Solving within Upper‐Elementary Science Education
Authors: Willemsen Robin H. , de Vink Isabelle C. , Kroesbergen Evelyn H. , Lazonder Ard W. 
Published: January 2024

ABSTRACTThis intervention study examined the effectiveness of instructional support tailored toward two techniques (i.e., random associations and constraint identification) to strengthen children's creative problem‐solving skills within upper‐elementary science education. Five inquiry‐based science lessons with ample opportunity for creative problem‐solving (i.e., divergent and convergent thinking) were provided. Children were assigned to a condition with instructional support (n = 107) or without (n = 134). Domain‐general and specific measures of divergent and convergent thinking were included, and reading comprehension as well as mathematical ability were taken into account. Repeated measures multivariate analyses of covariance revealed how all children improved in terms of domain‐general convergent thinking, with a larger increase for children who performed better in mathematics. This shows a promising premise for future research focusing on the domain generality of convergent thinking and for the potential of transfer across domains. No additional improvement based on instructional support was found and children did not improve in terms of divergent thinking. The constraint identification and random associations technique might not be suitable for elementary school children, yet future research is necessary to validate such claims. Meanwhile, teachers could possibly support convergent thinking by simply providing exercises for divergent and convergent thinking.
Synthesis, characterization, and corrosion protection potential of a highly effective and water‐miscible surfactant for mild steel in sulfuric acid solution
Authors: Yaagoob Ibrahim Y. , Goni Lipiar K. M. O. , Mazumder Mohammad A. J. , Verma Chandrabhan , Ali Shaikh A. , Alfantazi Akram 
Published: January 2024

AbstractIn the current study, a tetracationic quaternary ammonium salt (TCQAC) was synthesized and characterized and its ability to suppress corrosion on mild steel (MS) in a 0.5 M H2SO4 solution was examined. Various chemical, electrochemical, and surface characterization techniques were utilized to study the inhibition efficiency of TCQAC. The TCQAC manifests 99.83% efficiency at 20 ppm concentration. Out of all the examined isotherm models, the Langmuir isotherm offered the best fit for the TCQAC adsorption on the MS surface. A very high negative value of ΔGads (−45.18 kJ mol−1) suggests that the adsorption of TCQAC followed the chemisorption mechanism. Electrochemical studies indicate that TCQAC increases the linear and charge transfer resistances (LPR and Rct, respectively). TCQAC slows down the anodic and cathodic Tafel reactions; however, it acts as an anodic‐type inhibitor at 5, 10, and 20 ppm. The appearance of extra Cl and N signals in the energy dispersive x‐ray (EDX) spectrum and an improvement in surface smoothness in the scanning electron microscope (SEM) image of the inhibited sample corroborated the adsorption method of corrosion inhibition. X‐ray photoelectron spectroscopy (XPS) study indicates that TCQAC creates corrosion preventive layers by chemical adsorption. In Frontier molecular orbitals (FMOs), highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) were delocalized around the central part that comprises two benzyls, four allyls, and one hydrocarbon ((CH2)6) moieties and two quaternary nitrogen atoms. The outcomes of XPS and density functional theory (DFT) analyses indicate that the chemisorption of TCQAC occurs by dπ–pπ bonding with the surface iron atoms. The π‐electrons of aryl and allyl moieties extensively participate in the bonding.
The inhibitory action of lactocin 63 on deterioration of seabass (Lateolabrax japonicus) during chilled storage
Authors: Wu Peifen , Yang Jie , Meng Xiaojie , Weng Yanlin , Lin Yayi , Li Ruili , Lv Xucong , Ni Li , Han Jin‐Zhi , Fu Caili 
Published: January 2024

AbstractBackgroundThe bacteriocins, particularly derived from lactic acid bacteria, currently exhibit potential as a promising food preservative owing to their low toxicity and potent antimicrobial activity. This study aimed to evaluate the efficacy of lactocin 63, produced by Lactobacillus coryniformis, in inhibiting the deterioration of Lateolabrax japonicas during chilled storage, while also investigating its underlying inhibitory mechanism. The measurement of total viable count, biogenic amines, and volatile organic compounds were conducted, along with high‐throughput sequencing and sensory evaluation.ResultsThe findings demonstrated that treatment with lactocin 63 resulted in a notable retardation of bacterial growth in L. japonicas fish fillet during refrigerated storage compared with the water‐treated and nisin‐treated groups. Moreover, lactocin 63 effectively maintained the microbial flora balance in the fish fillet and inhibited the proliferation and metabolic activity of specific spoilage microorganisms, particularly Shewanella, Pseudomonas, and Acinetobacter. Furthermore, the production of unacceptable volatile organic compounds (e.g. 1‐octen‐3‐ol, hexanal, nonanal), as well as the biogenic amines derived from the bacterial metabolism, could be hindered, thus preventing the degradation in the quality of fish fillets and sustaining relatively high sensory quality.ConclusionThe results of this study provide valuable theoretical support for the development and application of lactocin 63, or other bacteriocins derived from lactic acid bacteria, as potential bio‐preservatives in aquatic food. © 2024 Society of Chemical Industry.
Linguistic and affective characteristics of script‐driven imagery for adults with posttraumatic stress order: Associations with clinical outcomes during deep transcranial magnetic stimulation
Authors: Guzick Andrew G. , Tendler Aron , Brown Lily A. , Onyeka Ogechi C. , Storch Eric A. 
Published: January 2024

AbstractBrief exposure to traumatic memories using script‐driven imagery (SDI) has been proposed as a promising treatment for posttraumatic stress disorder (PTSD). This study investigated the effect of SDI plus active versus sham deep transcranial magnetic stimulation (TMS) in a secondary analysis of a randomized controlled trial for adults with PTSD (N = 134). Linguistic features of scripts and self‐reported distress during a 12‐session deep TMS treatment protocol were examined as they related to (a) baseline PTSD symptom severity, (b) trauma characteristics, and (c) treatment outcomes. Linguistic Inquiry and Word Count (LIWC) software was used to analyze the following linguistic features of SDIs: negative emotion, authenticity, and cognitive processing. More use of negative emotion words was associated with less severe self‐reported and clinician‐rated baseline PTSD symptom severity, r = ‐.18, p = .038. LIWC features did not differ based on index trauma type, range: F(3, 125) = 0.29–0.49, ps = .688–.831. Between‐session reductions in self‐reported distress across SDI trials predicted PTSD symptom improvement across both conditions at 5‐week, B = ‐15.68, p = .010, and 9‐week endpoints, B = ‐16.38, p = .011. Initial self‐reported distress and linguistic features were not associated with treatment outcomes. The findings suggest that individuals with PTSD who experience between‐session habituation to SDI‐related distress are likely to experience a corresponding improvement in PTSD symptoms.
Environmental heterogeneity and habitat use of the red viscacha rat in drylands of west‐central Argentina
Authors: Tarquino‐Carbonell Andrea P. , Ojeda Ricardo A. , Sobrero Raúl , Ojeda Agustina A. 
Published: January 2024

AbstractEnvironmental heterogeneity shapes the traits of natural populations, including space use and burrowing behavior. We studied the red viscacha rat (Tympanoctomys barrerae), a semifossorial rodent with patchy distribution in drylands of west‐central Argentina, to provide ecological data on habitat and burrow features of this specialist species. We collected data on 165 burrows and 55 individuals from 2017–2018 and observed correlations between different vegetation types, vegetation diversity, and physical attributes (e.g., soil hardness). A high number of individual red viscacha rats was negatively associated with herbs. The number of burrow entrances was positively associated with harder soils and negatively associated with vegetation cover. Our results suggest that the species' patchy distribution is strongly associated with environmental heterogeneity of these arid environments, and consequently provide an essential step towards conserving their populations across their geographic range.
Measurement of TT‐TG can change with sequential MRIs due to variations in tibiofemoral rotation in patellofemoral instability patients
Authors: Pascual‐Leone Nicolas , Chipman Danielle E. , Davie Ryann , Bram Joshua T. , Mintz Douglas N. , Fabricant Peter D. , Green Daniel W. 
Published: January 2024

AbstractPurposeThere are various anatomic risk factors for patellofemoral instability (PFI) that help guide surgical treatment, including the tibial tubercle to trochlear groove (TT‐TG) distance. However, no study has analysed the temporal changes in TT‐TG prior to surgical intervention. This study sought to understand the variations in TT‐TG over time for pediatric patients suffering from PFI prior to surgical intervention. The authors hypothesised that the TT‐TG would substantially change between time points.MethodsPatients undergoing medial patellofemoral ligament (MPFL) reconstruction between 2014 and 2019 by one of two fellowship‐trained orthopaedic surgeons were identified. Patients were included if they had two preoperative magnetic resonance imaging (MRI) performed on the same knee within 7.5 months of each other prior to any surgical intervention and had an initial TT‐TG greater than 10 mm.ResultsAfter considering 251 patients for inclusion, 21 patients met the final inclusion criteria. The mean age was 14.5 ± 2.5 years and 61.9% were female. TT‐TG was initially noted to be 15.1 ± 1.8 mm. At mean time after sequential MRIs of 5.0 ± 1.9 months, TT‐TG was noted to be 16.7 ± 3.2 mm. The differences between initial and subsequent TT‐TG ranged from a 21.2% decrease to a 61.1% increase, with a mean difference of an 11.3% increase. Comparison between initial and subsequent TT‐TG values demonstrated a significant difference (p = 0.017). Change in tibiofemoral rotation ranged from −9.2° to 7.5°. When comparing the change in TT‐TG to change in tibiofemoral rotation, a significant correlation was found (p = 0.019).ConclusionDespite only a mean time between MRIs of 5 months, variations in TT‐TG ranged from a decrease of 21.2% to an increase of 61.1%. The significant relationship between the changes in TT‐TG and changes in tibiofemoral rotation between MRIs suggest that TT‐TG measurements may vary due to variations in tibiofemoral rotation at the time of individual MRIs.Level of Evidence: Level IV.
Management after acute injury of the anterior cruciate ligament (ACL). Part 3: Recommendation on surgical treatment
Authors: Häner Martin , Stoffels Thomas , Guenther Daniel , Pfeiffer Thomas , Imhoff Andreas , Herbort Mirco , Stein Thomas , Schoepp Christian , Akoto Ralph , Höher Jürgen , Scheffler Sven , Stöhr Amelie , Mehl Julian , Niederer Daniel , Jung Tobias , Kittl Christoph , Eberle Christian , Vernacchia Cara , Ellermann Andree , Braun Philipp‐Johannes , Krause Matthias , Mengis Natalie , Müller Peter E. , Best Raymond , Achtnich Andrea , Petersen Wolf 
Published: January 2024

AbstractPurposeThe aim of this consensus project was to give recommendations regarding surgical treatment of the anterior cruciate ligament (ACL) injured patient.MethodsFor this consensus process, an expert, steering and rating group was formed. In an initial online meeting, the steering group, together with the expert group, formed various key topic complexes for which multiple questions were formulated. For each key topic, a structured literature search was performed by the steering group. The results of the literature review were sent to the rating group with the option to give anonymous comments until a final consensus voting was performed. Sufficient consensus was defined as 80% agreement.ResultsDuring this consensus process, 30 topics regarding the surgical management and technique of ACL reconstruction were identified. The literature search for each key question resulted in 30 final statements. Of these 30 final statements, all achieved consensus.ConclusionsThis consensus process has shown that surgical treatment of ACL injury is a complex process. Various surgical factors influence patient outcomes. The proposed treatment algorithm can be used as a decision aid for the surgeon.Level of EvidenceLevel V.