bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of neridronate on axial involvement in patients with spondyloarthritis when biologics are not possible. Results of a monocentric study
Authors: Crotti Chiara , Di Taranto Raffaele , Orsini Francesco , Ferrito Matteo , Varenna Massimo , Favalli Ennio Giulio , Caporali Roberto 
Published: November 2023

IntroductionThis study aims to examine the potential effectiveness of intravenous neridronate (IVNer) on axial involvement in patients with spondyloarthritis (SpA) refractory to non-steroidal anti-inflammatory drugs (NSAIDs) but not eligible for biological disease-modifying antirheumatic drugs (bDMARDs).MethodPatients with active SpA (BASDAI score ≥ 4) and active sacroiliitis (SI) on MRI (according to ASAS MRI definition), who were NSAID-insufficient responder/intolerant but not eligible for bDMARDs, were retrospectively recruited in a tertiary rheumatology centre between September 2015 and December 2021. IVNer (100 mg) was administered to the patients on days 1, 4, 7, and 10. Responses were evaluated 60 days after the last infusion as the median changes from the baseline of BASDAI and Visual Analogue Scale (VAS) pain and there are improvements on MRI signs.ResultsA total of 38 patients (26 axial SpA, 3 enteropathic arthritis, and 9 axial psoriatic arthritis) were included [66% women, mean age ± SD: 38.0 ± 14.1 years, mean disease duration: 30.5 ± 49.5 months (range 1.0–298), 47% HLAB27+]. The reason for bDMARD ineligibility was concurrent solid tumors (n = 6) or hematological (n = 1) malignancy, comorbidities (n = 11), or patient preference (n = 20). Both median BASDAI [5.83 (4.2–8.33) versus 3.66 (1.1–6.85), p &lt; 0.001] and VAS pain [7 (5.75–8.0) versus 3 (1.0–7.0), p &lt; 0.0001] significantly decreased after IVNer. Of 28 available MRI at follow-up, we observed a complete (36%) or partial (39%) resolution of sacroiliitis or a persistent activity (25%).DiscussionIVNer was effective in improving axial involvement in patients with SpA refractory to NSAIDs but not eligible for bDMARDs. IVNer can be considered as a potential alternative therapeutic option in selected settings.
Feasibility of fast, four-dimensional computed tomography-based O-ring LINAC plans for lung stereotactic body radiotherapy in patients with poor performance status
Authors: Heo Eun Jeong , Kim Minseok , Park Chun Gun , Chang Kyung Hwan , Kim Kwang Hyeon , Shim Jang Bo , Park Young Je , Kim Chul Yong , Lee Nam Kwon , Lee Suk 
Published: November 2023

PurposeWe aimed to retrospectively analyzed the feasibility of fast four-dimensional computed tomography (4DCT)-based O-ring LINAC treatment for patients with an average respiratory amplitude was&lt; 0.5 cm and who cannot endure long treatment times due to poor performance status in lung 4D-stereotactic body radiotherapy (SBRT).MethodsThis study included data of 38 patients who received lung 4D-SBRT and had average respiratory amplitude&lt; 0.5 cm in the full phase. C-arm LINAC plans were based on 4DCT data obtained at phase values ranging from 20–70% using a C-arm LINAC. O-ring LINAC plans were retrospectively established based on 4DCT data obtained at phase values of 0–90% using an O-ring LINAC. The conformity index (CI), homogeneity index (HI), and gradient measurement of the planning target volumes (PTV) were analyzed to compare dosimetric data between C-arm LINAC and O-ring LINAC plans. Organs at risk were analyzed in accordance with the Radiation Therapy Oncology Group 0915 protocol. Treatment delivery time and total monitor units were analyzed to compare the efficiency of treatment delivery. Statistical comparisons were performed using the Wilcoxon signed-rank test (P&lt; 0.05).ResultsFor the PTV, there was no significant difference in the CI or HI between C-arm LINAC and O-ring LINAC plans. For organs-at-risk, all plans met the criteria for dose constraint. There was a significant difference between C-arm LINAC and O-ring LINAC plans except in the spinal cord. Treatment delivery time was 92% longer for C-arm LINAC plans than for O-ring LINAC plans. The total MU value for C-arm LINAC plans was 9.6% higher than that for O-ring LINAC plans.ConclusionWe verified the feasibility of fast 4DCT-based O-ring LINAC treatment for patients with average respiratory amplitude&lt; 0.5 cm and who cannot endure long treatment times due to poor performance status in lung 4D-SBRT.
Recent antitumor therapy does not increase Omicron COVID-19 severity in cancer patients: a two-center retrospective study in China
Authors: Liu Ying , Zhu Wenyao , Wang Zhiwu , Yu Jiarui , Dong Liang , Li Chunyang , Wang Wei , Zhang Fuhui , Ding Shuanghui , Sun Lu , Yang Zhao , Zhang Chao , Qian Fang 
Published: November 2023

BackgroundThe impact of anticancer therapy and related clinical factors on the severity of COVID-19 in cancer patients during the Omicron pandemic has not been established. The recent outbreak in China caused predominantly by the BA.5.2 and BF.7 strains of Omicron provided us with the opportunity to observe objectively the impact of this strain in oncology patients. We initiated this two–center retrospective study in China to determine the impact of anti-cancer treatment, other clinical factors, and cancer characteristics on COVID-19 severity in cancer patients infected with coronavirus during the SARS-CoV-2 Omicron variant pandemic in China.MethodsWe retrospectively included 554 cancer patients infected with COVID-19 from two medical centers. Data on their anticancer treatment prior to COVID-19 infection and general clinical characteristics (sex, age, past medical history, etc.) were collected. Univariate statistical analysis was performed to identify the factors associated with the severity of COVID-19.ResultsAmong 554 cancer patients infected with COVID-19, there were 15 (2.7%) severe/critical cases, 86 (15.5%) cases with medium severity, and 453 (81.8%) cases with mild severity. Univariate analysis revealed that advanced age, male sex, worse ECOG score, unvaccinated status, and previous liver, kidney, and brain diseases were associated with more severe COVID-19. However, recent antitumor therapy, including cytotoxic chemotherapy within two weeks did not have a significant correlation with the severity of COVID-19 caused by the Omicron variant.ConclusionThe severity of COVID-19 caused by the Omicron variant is not exacerbated by recent anticancer therapy in cancer patients. Therefore, anticancer therapy should not be discontinued in such cases, especially those with mild severity.
The Hypotensive and Vasodilatory Effects Observed in Rats Exposed to Chiranthodendron pentadactylon Larreat Flowers Can Be Attributed to Cyanidin 3-O-Glucoside
Authors: Escobar-Ramírez Juan Luis , Santiago-Mejía Jacinto , Soto-Núñez Maribel , Barrera-Vázquez Oscar Salvador , Vargas-Querea Roberto , Magos-Guerrero Gil Alfonso 
Published: November 2023

Chiranthodendron pentadactylon Larreat is a tree native to southeastern Mexico and Guatemala. Its flower is used in Mexican folk medicine to treat a variety of diseases, including conditions of blood pressure. However, scientific information on its usefulness in this pathology is lacking. The present study evaluates the effect of a methanolic extract (ME) from the flower and its active constituents on heart rate (HR) and mean arterial pressure (MAP) in anesthetized rats (MAPHR). The study also analyzed the effects on rat-isolated aortic rings (RIAR) and the rat mesenteric arterial bed (MABR). Active fractions were chromatographed, which led to the isolation of cyanidin 3-O-glucoside (C3G) identified through HPLC. The Chiranthodendron pentadactylon flowers produced hypotensive and vasorelaxant effects associated with C3G. The vasorelaxant effect is a mechanism underlying the synthesis and release of nitric oxide (NO). Neither cholinergic receptors nor prostaglandins are involved. ME and C3G cause cardiovascular depression in anesthetized rats via cholinergic and prostanoid mechanisms. Our research expands the scientific understanding of the flowers on the rat cardiovascular system. This amplifies the appreciation of the flower’s ethnomedicine employed to control blood pressure. However, researchers need to conduct toxicity studies to determine the safety of this plant.
Estilos de aprendizaje y rendimiento académico en estudiantes de una universidad nacional peruana
Authors: Orosco Toribio Eduardo Gottardo , Orosco León Omar Eduardo , Salguero Alcala Ginger Kimberly , Vega Vilca Carlos Sixto 
Published: November 2023

El rendimiento académico es una preocupación constante, tanto de los maestros como de los estudiantes, debido a que es el resultado de las enseñanzas que se dan en clase; es por ello, que últimamente se ha considerado de suma importancia los diferentes estilos de aprendizaje que desarrollan los estudiantes. El objetivo fue establecer la relación entre los estilos de aprendizaje y el desempeño académico en discentes de enfermería. La metodología fue por medio de la investigación descriptiva, correlacional y no experimental. El instrumento fue un cuestionario de estilos de aprendizaje de Alonso et al. (CHAEA) y las actas promocionales para el rendimiento académico. Como resultados se mostró una correlación positiva fuerte con un p=0.856 entre el logro académico y los estilos de aprendizaje. Concluyéndose que el desempeño académico tiene relación directa con el estilo reflexivo y teórico; y, presenta una relación directa moderada con el estilo activo y estilo pragmático.
Plataformas educativas virtuales en el desempeño profesional de docentes de educación básica regular
Authors: Raggio Ramírez Giuliana Del Socorro , Grados Zavala Elizabeth , Tang Almeida Ana Esther , Carpio Valencia Fortunato Edmundo 
Published: November 2023

La pandemia por la COVID-19, generó que las instituciones educativas tuviesen que adaptar sus métodos de enseñanzas tradicionales a sesiones online, los cual representó reto a los profesionales de la docencia. Por ello, el propósito de este estudio analizar la incidencia de la gestión de plataformas educativas virtuales en el desempeño profesional en docentes de educación básica regular. Se utilizó un enfoque cuantitativo con diseño no experimental de corte transversal-correlacional causal. Se aplicaron dos cuestionarios con escala tipo Likert a una muestra de 50 docentes. Los resultados indican que la gestión de plataformas educativas virtuales influye significativamente en el desempeño profesional de los docentes, lo que tiene implicaciones importantes para mejorar el aprendizaje de los estudiantes. Se obtuvo un valor de Wald de 19,005 y p: ,016 < ,050, lo que indica que la influencia de las plataformas educativas virtuales es estadísticamente significativa. En conclusión, el uso de plataformas educativas virtuales es un factor clave en el desempeño profesional docente en educación básica regular.
Reservatório para armazenamento e reaproveitamento de águas pluviais: uma possibilidade para redução do consumo de água no município de Jutaí-AM
Authors: De Oliveira Júnior Mário Jorge Ramos , Pinheiro Érika Cristina Nogueira Marques , Coelho Ilsa Maria Honório de Valois 
Published: November 2023

Este artigo tem como objetivo mostrar a necessidade de se maximizar a eficiência do uso dos recursos naturais e o reaproveitamento das águas pluviais no município de Jutaí-Amazonas. Neste sentido, a proposta de instalar um sistema para captação de águas pluviais numa escola pública do município suscitará reflexões na comunidade sobre a redução do desperdício de água, promovendo a conscientização sobre o uso sustentável desse recurso natural. Trata-se de uma pesquisa bibliográfica, qualitativa e exploratória, que investe no conhecimento técnico sobre os Sistemas de Armazenamento de Águas Pluviais (SAAP) e na disseminação da ideia de viabilidade desses sistemas no município de Jutaí. Foi considerada a falta de infraestrutura adequada nas escolas da rede de ensino público o que torna inviável, no momento, o aproveitamento das águas pluviais no município. No entanto a proposta se justifica principalmente porque a precipitação de chuvas é acentuada naquele município e o abastecimento é feito via poço artesiano, para cujo funcionamento necessita de energia elétrica. Como resultado adicional espera-se um crescimento da consciência sobre a importância do uso sustentável dos recursos disponíveis com base no tripé sociedade, ambiente e economia, possibilitando uma nova relação mais equilibrada entre o homem e o meio.
ANÁLISE COMPARATIVA DO TESTE RÁPIDO IMUNOCROMATOGRÁFICO - TR-DPP® E IMUNOENZIMÁTICO - ELISA NO DIAGNÓSTICO DA LEISHMANIOSE VISCERAL CANINA
Authors: Paulino da Cruz Vieira Vanessa , Eustáquio Mendes Silva Selvino , Rodrigues Gomes Neto Geraldo 
Published: November 2023

Através de um estudo transversal, descritivo e quantitativo, objetivou-se realizar realizar uma comparação entre os resultados obtidos no teste rápido imunocromatográfico (TR-DPP® LVC Bio-Manguinhos) e no ensaio imunoenzimático (ELISA), no diagnóstico da leishmaniose visceral canina (LVC) em Salinas, Norte de Minas Gerais. Participaram do estudo cães errantes apreendidos pela Vigilância em Saúde, submetidos ao TR-DPP® para triagem e ELISA para confirmação dos animais “suspeitos” de LVC. Realizou-se o TR-DPP® em 223 cães de ambos os sexos, raças e idades variadas. Os resultados revelaram 54 animais reagentes no TR-DPP®, sendo classificados como “suspeitos”, e desses, 22 foram confirmados pelo ELISA. O cálculo do Valor Preditivo Positivo (VPP) do TR-DPP® foi de 40,7%, utilizando o ELISA como padrão-ouro. O resultado do VPP demonstra que o TR-DPP® pode e deve ser usado como uma ferramenta auxiliar de diagnóstico e controle da LVC em Salinas, Norte de Minas Gerais, tendo sua importância balizada na detecção precoce de uma possível disseminação da LVC, evitando a possibilidade de surtos. No entanto, enfatiza-se a necessidade de confirmação por métodos diagnósticos mais sensíveis e específicos, para a correta tomada de decisões acerca das ações em programas de saúde pública, no combate à LVC.
Integrating exosuit capabilities into clothing to make back relief accessible to workers unserved by existing exoskeletons: design and preliminary evaluation
Authors: Wolf Derek , Fine Shimra , Ice Chad , Slaughter Paul , Rodzak Katherine , Zelik Karl 
Published: November 2023

<p>Background: Occupational exos (rigid exoskeletons and soft exosuits) are emerging technologies designed to reduce the risk of work-related musculoskeletal disorders. Existing occupational exos are standalone accessories worn on top of a user’s clothing. </p>
<p>Purpose: Our objective was to test and verify that back-assist exosuit capabilities could be integrated into regular clothing in an effective and usable manner, which could make musculoskeletal relief accessible to more workers.</p>
<p>Methods: We redesigned a previously validated accessory exosuit so it could integrate into a standard-issue U.S. Army uniform. The uniform-integrated exosuit prototype was low-profile (protruding <30 mm from the body), lightweight (adding 800 grams to the uniform), and could be donned/doffed like normal clothing. We verified the effectiveness and usability of the prototype in lab testing (<em>N</em>=5) and in a case study (<em>N=</em>1) with a U.S. Army Soldier.</p>
<p>Results: In lab testing (<em>N</em>=5), this exosuit provided 18-27 Nm of torque about the low back during lifting. Assistance could be engaged or disengaged one-handed in about half a second, and the exosuit did not restrict a user’s natural range of motion or cause discomfort. A case study (<em>N</em>=1) with a Soldier performing operationally relevant tasks demonstrated that this type of uniform-integrated exosuit may be well-suited for workers with duties that involve driving in vehicles and intermittent lifting. </p>
<p>Conclusions: This work verified that integrating back-assist exosuit capabilities into standard workwear can be effective and usable. The integration resulted in little change to the form factor, weight, range of motion, or comfort of the standard daily uniform while adding lifting assistance. This new sub-class of exosuit could be beneficial to workers who alternate between bending, lifting, and sitting tasks, or to those in customer- or patient-facing jobs where it is important for wearable technology to be discreet.</p>
Rotational Balancing for Parallel Connection of Batteries and Reducing the Number of Components in Multi-level Inverters
Authors: Hamid Muhammad , Xie Jian 
Published: November 2023

<p>The paper aims to try to push the current conecpt about reduced switch count Multi-level inverter (RSC-MLI) for battery sotage systems. They can be used to reduce the count of Mosefts used in Home storage systems(HSS); However, it would require precise Voltage measuring instruments and a complexer code to control the switching of Mosfets. To smooth the on /off step function, one can also use an inductor.</p>
<p>The research sparked interest during Covid phase when the prices of certain Mosfets increased 20 folds. </p>
DINAMIKA KELOMPOK PENGOLAH HASIL PERIKANAN (POKLAHSAR) “KAMILAH’’ DI KELURAHAN PEJALA KECAMATAN PENAJAM KABUPATEN PENAJAM PASER UTARA
Authors: Gunawan Bambang Indratno , Sugiharto Eko , Suhri Muhammad 
Published: November 2023

Penelitian ini bertujuan untuk: 1) Mengetahui tingkat dinamika kelompok pengolah hasil perikanan KAMILAH Di Kelurahan Pejala Kecamatan Penajam Kabupaten Penajam Paser Utara; 2) Mengetahui profil kelompok poklahsar kamilah. Metode pengambilan sampel yang digunakan adalah metode sensus dengan jumlah responden yang diambil sebanyak 10 oramg anggota kelompok poklahsar KAMILAH. Metode analisis yang digunakan adalah skala Likert untuk menganalisis tingkat dinamika kelompok . Hasil penelitian ini menunjukkan bahwa tingkat dinamika kelompok poklahsar KAMILAH pada setiap indikator tujuan kelompok, struktur kelompok, pembinaan dan pengembangan kelompok, kekompakan kelompok, suasana kelompok, tekanan kelompok, keefektifan kelompok, maksud terselubung berada pada kategori dinamis sedangkan indikator fungsi dan tugas pada kategori sedang. Secara akumulasi keseluruhan tingkat dinamika kelompok poklahsar KAMILAH pada kategori tinggi dengan nilai skor 74,4 . Hal ini dapat disimpulkan bahwa kelompok poklahsar KAMILAH tidak slalu dalam kondisi statis, tetapi berada pada kondisi dinamis yang berubah dalam kehidupan kelompok.
EFEITO DAS SOLUÇÕES IRRIGADORAS USADAS EM ENDODONTIA REGENERATIVA SOBRE AS CÉLULAS-TRONCO DE ORIGEM DENTAL
Authors: Ferreira Antônio Fabricio Alves , Brito Sávio José da Silva , Guimarães Samara de Freitas , Andrade Renato Leonardo Santos de , Lima Mabel Martins , Lima Emanuela Carolaine Teixeira , Santana Késia Zamerim , Lau Pedro Lucas de Carvalho , Pereira Katia Caetana , Monteiro Vinicius Ribeiro 
Published: November 2023

As células-tronco derivadas dos dentes atuam na manutenção da homeostase pulpar, além de possuir alta plasticidade e pluripotência, vale ressaltar que a região da papila apical está repleta de células-tronco mesenquimais (SCAPs), que podem sobreviver à infecção endodôntica, e conjuntamente com a bainha epitelial da raiz de Hertwig, eles direcionam o desenvolvimento da raiz. Portanto, regenerativo terapias endodônticas são necessárias para dentes imaturos manterem a viabilidade dessas estruturas e garantir o processo completo de maturação radicular. A endodontia regenerativa a terapia ainda está evoluindo, faltando evidências da pesquisa translacional e clínica apoiar a escolha informada do médico sobre o melhor protocolo de irrigação terapêutica para promover a liberação de fatores de crescimento dentinário e reparo tecidual. Além disso, estudos clínicos heterogeneidade e complexidade inerentes prejudicaram a avaliação dos dados sobre a liberação de fatores de crescimento durante terapias endodônticas regenerativas.
Perancangan Video Motion Graphic Labuan Bajo Sebagai Media Promosi Destinasi Wisata
Authors: Cilla Nola Ardelia Vorna , Rachman Anung , Kurniawan Rendya Adi 
Published: November 2023

Seiring berkembangnya zaman, sektor pariwisata Indonesia mulai meningkatkan potensi tempat wisata lebih inovasi tetapi tetap mempertahankan budaya asli. Tujuan dari perancangan video motion graphic ini untuk meningkatkan wisatawan datang ke tempat wisata Labuan Bajo. Perancangan video ini menggunakan metode pengembangan proyek multimedia “Multimedia Development Life Cycle (MDLC) yang menghasilkan total durasi 58 detik. Video motion graphic ini diunggah di media sosial TikTok yang telah melalui uji persepsi menggunakan google form. Berdasarkan hasil kuisioner terdapat 50 responden mengatakan video ini mempunyai respon yang baik dan efektif sehingga dapat digunakan sebagai iklan media promosi pariwisata. Iklan motion graphic dapat menambah daya tarik untuk mengundang datang ke Labuan Bajo.
Efektivitas Event Marketing Loop Musik Terhadap Peningkatan Citra Merek di Kalangan Siswa-Siswi SMK Telkom Medan
Authors: Ardelisma Ayeisha 
Published: November 2023

Penelitian ini meneliti bagaimana event marketing Loop Musik meningkatkan brand image di kalangan siswa SMK Telkom Medan. Teori Pemasaran, Bauran Pemasaran, PR, Event Marketing, Merek, dan Citra digunakan. Metode deskriptif, korelasional, dan pengujian hipotesis dengan menggunakan T-Test dan t (tabel) digunakan dalam penelitian kuantitatif ini. Metode pengumpulan data menggunakan kuesioner dan penelitian kepustakaan. Total sampel sebanyak 21 siswa SMK Telkom Medan yang menghadiri Loop Musik digunakan dalam penelitian ini. Metode pengambilan sampel dilakukan secara purposive. Analisis data meliputi deskriptif, korelasi, dan pengujian hipotesis menggunakan model T-Test IBM SPSS atau "Paired Sample T-Test". Berdasarkan hasil program Windows 22.0, promosi event Loop Musik berpengaruh signifikan terhadap citra merek kartu Loop (t = t (hitung) < t (tabel). Event Marketing Loop Musik meningkatkan brand awareness kartu Loop di kalangan siswa SMK Telkom Medan.
Reproducibility of instantaneous wave-free ratio and angiography coregistration in patients with coronary heart disease and diffuse and multilevel coronary artery lesion
Authors: Bubnov D. S. , Atanesyan R. V. , Kardanakhishvili Z. B. , Ageev F. T. , Matchin Yu. G. 
Published: November 2023

Aim. To determine the reproducibility of the results of instantaneous wavefree ratio (iFR) and angiography coregistration in patients with coronary heart disease (CAD) with multilevel and diffuse lesions of the coronary arteries.Materials and methods. The study included 34 patients with chronic ischemic heart disease (CAD) with diffuse and/or multilevel coronary stenoses >50%. In 41 coronary arteries, two consecutive iFR pullback of the conductor were performed and paired iFR angio-coregistrations were formed, reflecting changes in iFR gradients (Δ iFR) along the entire length of the studied artery. To compare the results of paired studies, the following values were used: 1) indices of distal iFR; 2) maximum Δ iFR; 3) Δ iFR of all stenoses ˃50%.Results. Comparable values of distal iFR were obtained 0,84 [0,78; 0,89] vs. 0,85 [0,77; 0,88]) with an average difference of the first and second measurements of 0,001, maximum ΔiFR (0,08 [0,05; 0,14] vs. 0,08 [0,05; 0,13]) with a mean difference of -0,004 and ΔiFR of all stenoses >50% (0,05 [0,02; 0,11] vs. 0,05 [ 0,02; 0,10]) with an average difference of -0.001. Lin’s concordance correlation coefficient and Intraclass Correlation Coefficients calculated for the three parameters studied showed a good level of agreement (0,97; 0,98; 0,98) with excellent reliability (0,97; 0,98; 0,97).Conclusion. In patients with multilevel and diffuse lesions of the coronary artery, iFR angio-coregistration has a fairly high reproducibility.