bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of stress field induced by natural fracture and its influence on hydraulic fracture propagation
Authors: Shi Shanzhi , Wang Mingxing , Tang Wei , Pan Yuting , Jin Haozeng , He Jiale , Hou Lei , Xie Bobo , Chen Xi , Lv Zhao 
Published: February 2024

AbstractThe change of fracture propagation direction caused by stress interference between fractures is one of the main reasons that affect shale gas productivity. Natural fractures will be damaged by the induced stress, and the induced stress field produced by natural fracture damage will in turn affect the propagation of hydraulic fractures. Previous studies usually ignored the impact of stress field variation caused by natural fracture damage, leading to inaccurate fracture propagation simulation results. A new model for simulating hydraulic fracturing-induced stress field is established with consideration of the influence of natural fracture damage. Then, the natural fracture-induced stress is analyzed in open and closed fracture states. Through superposition of stress fields of natural fractures and hydraulic fractures, the interaction among open and closed natural fractures, reservoir and hydraulic fracture, and the corresponding fracture property evolution are studied. The results demonstrate that induced stress is not affected by elastic modulus and Poisson's ratio of the rock. The induced stress difference at the fracture tip is proportional to the net pressure and the length of hydraulic fractures. The results provide guidance for the optimal design of fracturing. When the deflection angle of hydraulic fracture is less than 90°, the maximum induced stress difference at the fracture tip decreases with the reduction in the deflection angle. When the deflection angle of hydraulic fracture is smaller than 90° or the deflection angle of natural fracture is smaller than 45°, the steering of hydraulic fracture is less hindered, which is beneficial to the formation of complex fracture network.
Verifying antibacterial properties of nanopillars on cicada wings
Authors: van Nieuwenhoven Richard W. , Bürger Alexander M. , Mears Laura L. E. , Kienzl Philip , Reithofer Manuel , Elbe-Bürger Adelheid , Gebeshuber Ille C. 
Published: February 2024

AbstractThe antibacterial properties of cicada wings originate from hexagonally arranged pillar-like multi-functional nanostructures with species-dependent heights, which are super-hydrophobic and self-cleaning. In the present study, two cicada species with promising nanopillars were investigated in more detail. Selected methods were used to analyze the wing surfaces, including Atomic Force Microscopy, Scanning Electron Microscopy, and bacterial tests with live/dead staining. Verifying the antibacterial properties posed challenges, such as the bacteria concentration needed to confirm the antibacterial properties. These challenges will also impact the practical implementation of antibacterial nanostructures and support the findings of recent critical publications.
On the concentration-compactness principle for anisotropic variable exponent Sobolev spaces and its applications
Authors: Chems Eddine Nabil , Ragusa Maria Alessandra , Repovš Dušan D. 
Published: February 2024

AbstractWe obtain critical embeddings and the concentration-compactness principle for the anisotropic variable exponent Sobolev spaces. As an application of these results,we confirm the existence of and find infinitely many nontrivial solutions for a class of nonlinear critical anisotropic elliptic equations involving variable exponents and two real parameters. With the groundwork laid in this work, there is potential for future extensions, particularly in extending the concentration-compactness principle to anisotropic fractional order Sobolev spaces with variable exponents in bounded domains. This extension could find applications in solving the generalized fractional Brezis–Nirenberg problem.
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Authors: Ribeiro Joana , Araújo-Silva Henrique , Fernandes Mário , da Silva Joilna Alves , Pinto Francisco das Chagas L. , Pessoa Otília Deusdenia L. , Santos Hélcio Silva , de Menezes Jane Eire Silva Alencar , Gomes Andreia C. 
Published: February 2024

AbstractAccording to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer’s Disease (AD). A crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (AChE) activity. Marine organisms synthesize several classes of compounds, some of which exhibit significant AChE inhibition, such as petrosamine, a coloured pyridoacridine alkaloid. The aim of this work was to characterize the activity of petrosamine isolated for the first time from a Brazilian marine sponge, using two neurotoxicity models with aluminium chloride, as exposure to aluminium is associated with the development of neurodegenerative diseases. The in vitro model was based in a neuroblastoma cell line and the in vivo model exploited the potential of zebrafish (Danio rerio) embryos in mimicking hallmarks of AD. To our knowledge, this is the first report on petrosamine’s activity over these parameters, either in vitro or in vivo, in order to characterize its full potential for tackling neurotoxicity.
Graphical Abstract
Non-surgical Treatment of Adenomyosis
Authors: Dedes Ioannis , Kolovos Georgios N. , Mueller Michael D. 
Published: February 2024

Abstract
Purpose of Review
Uterine-sparing excisional surgical techniques for adenomyosis are complex, carry significant risks, and after all have substantial recurrence rates. Consequently, there has been a trend towards adopting non-surgical treatments. This narrative review outlines the latest in non-surgical treatments for adenomyosis, highlighting their significance in managing this condition and stresses the importance of further research, especially concerning long-term outcomes and fertility implications.

Recent Findings
Emerging evidence suggests that non-surgical techniques for the treatment of adenomyosis offer promising alternatives to traditional uterus-conserving surgery.

Summary
LNG-IUS is recommended as the primary management strategy for adenomyosis. In our clinical evaluation, a pretreatment with GnRH-analogs, HIFU, or UAE prior to LNG-IUS insertion in enlarged uteri may mitigate treatment failure risks, notably device expulsion. Concurrently, post-intervention LNG-IUS application post non-surgical modalities can diminish recurrence probability. In large uteri with presence of multiple uterine fibroids, UAE may be preferable compared to thermal ablation procedures especially if there is no wish for pregnancy or comorbidities not allowing for a hysterectomy. For focal adenomyosis, especially when prioritizing fertility preservation, RFA may be considered due to its precise targeting, available data on pregnancy outcomes, and ease of incorporation into gynecological practice. In cases of localized disease of the anterior wall of the uterus without prior surgeries and no suspicion of concurrent endometriosis, HIFU can be favored.
Ending the HIV Epidemic in Black America: Qualitative Insights Following COVID-19
Authors: Lewis Tenesha J. , Herring R. Patti , Chinnock Richard E. , Nelson Anna 
Published: February 2024

Abstract
Background
The disproportionate effects of the human immunodeficiency virus (HIV) and the Coronavirus 2019 (COVID-19) on Black American communities highlight structural systems rooted in racism and must be addressed with national strategies that improve both biomedicine and social determinants of health.

Purpose
The purpose of this study was to qualitatively examine the experiences and interpretations of experts in the HIV workforce (local, state, and national HIV-related organizations) regarding the state of HIV and COVID-19 among Black Americans.

Methods
Within key informant interviews and a focus group recorded and transcribed verbatim, fifteen members of the HIV workforce and Black community described their experiences and provided insights to inform ending the negative outcomes resulting from HIV and COVID-19.

Results
Data were analyzed using NVivo software, and eight themes emerged to address disease disproportionality through a Black lens. Themes reflected (1) accessing information and care; (2) key potential partners/stakeholders; (3) investing in Black communities; (4) governmental support; (5) increasing engagement and advocacy; (6) HIV-related community conversations; (7) developments since COVID-19; and (8) the Ending the HIV Epidemic (EHE) trajectory.

Conclusions
Themes directly speak to recommendations to adjust education and policy strategies for HIV and COVID-19 prevention and intervention. Such recommendations, (1) amplifying Black voices, (2) investing sustainable dollars into Black communities, and (3) leaning into advocacy, can bolster the foundation for the HIV workforce and Black community to break ineffective response patterns and lead the fight against these systemic issues of inequity.
Measurement of antioxidant synergy between phenolic bioactives in traditional food combinations (legume/non-legume/fruit) of (semi) arid regions: insights into the development of sustainable functional foods
Authors: Joshi Tripti , Agrawal Kartik , Mangal Manan , Deepa P. R. , Sharma Pankaj Kumar 
Published: February 2024

AbstractNumerous under-researched edible plants are present in the desert regions of the world. These plants could be potential candidates to ensure food security and provide valuable bioactive compounds through diet. In general, the bioactives present in food manifest synergistic, additive, or antagonistic interactions. The current study investigates such interactions between food combinations traditionally consumed in (semi) arid regions. Five edible plants (representing three food categories) were selected: Prosopis cineraria and Acacia senegal (legume), Capparis decidua and Cordia dichotoma (non-legume), and Mangifera indica (fruit), in which the first four are largely underutilized. The antioxidant capacities of individual plant extracts and their binary mixtures were analyzed by DPPH free radical scavenging and FRAP assays. The total phenolic content (TPC) and total flavonoid content (TFC) were also determined. The highest antioxidant activity was obtained for Prosopis cineraria extract (EC50—1.24 ± 0.02 mg/ml, FRAP value—380.58 ± 11.17 μM/g), while Mangifera indica exhibited the lowest antioxidant activity (EC50—2.54 ± 0.05 mg/ml, FRAP value—48.91 ± 4.34 μM/g). Binary mixture of Prosopis cineraria (legume) and Mangifera indica (fruit) manifested maximum synergy (experimental EC50—0.89 ± 0.01 mg/ml, theoretical EC50—3.79 ± 0.05 mg/ml). Correlation studies [Pearson’s correlation coefficient (r) and Principal component analysis (PCA)] showed a high correlation of TFC with DPPH and TPC with FRAP values. LC–MS analysis of methanolic plant extracts detected 43 phenolic compounds (including phenolic acids, flavonoids, and isoflavonoids), possibly responsible for the observed food synergy. For edible plants of the (semi) arid zones, this study is a first-of-its-kind and provides scientific validation to the traditional wisdom of consuming these foods together. Such indigenous food combinations derived from desert flora could offer valuable insights into development of sustainable functional foods and nutraceuticals.
Graphical Abstract
Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults
Authors: Debras Charlotte , Cordova Reynalda , Mayén Ana-Lucia , Maasen Kim , Knaze Viktoria , Eussen Simone J. P. M. , Schalkwijk Casper G. , Huybrechts Inge , Tjønneland Anne , Halkjær Jytte , Katzke Verena , Bajracharya Rashmita , Schulze Matthias B. , Masala Giovanna , Pala Valeria , Pasanisi Fabrizio , Macciotta Alessandra , Petrova Dafina , Castañeda Jazmin , Santiuste Carmen , Amiano Pilar , Moreno-Iribas Conchi , Borné Yan , Sonestedt Emily , Johansson Ingegerd , Esberg Anders , Aglago Elom Kouassivi , Jenab Mazda , Freisling Heinz 
Published: February 2024

AbstractDicarbonyl compounds are highly reactive precursors of advanced glycation end products (AGE), produced endogenously, present in certain foods and formed during food processing. AGE contribute to the development of adverse metabolic outcomes, but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO) and 3-deoxyglucosone (3-DG), and body weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263 095 European Prospective Investigation into Cancer and Nutrition–Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home in Relation to Anthropometry participants with two body weight assessments (median follow-up time = 5·4 years). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0·089 kg (per 1-sd increase, 95 % CI 0·072, 0·107). 3-DG was inversely associated with body-weight change (–0·076 kg, −0·094, −0·058). No significant association was observed for GO (0·018 kg, −0·002, 0·037). In stratified analyses, GO was associated with body-weight gain among women and older participants (above median of 52·4 years). MGO was associated with higher body-weight gain among older participants. 3-DG was inversely associated with body-weight gain among younger and normal-weight participants. MGO was associated with a higher risk of becoming overweight/obese, while inverse associations were observed for 3-DG. No associations were observed for GO with overweight/obesity. Dietary dicarbonyls are inconsistently associated with body weight change among European adults. Further research is needed to clarify the role of these food components in overweight and obesity, their underlying mechanisms and potential public health implications.
How does trade policy uncertainty affect firms’ pollution emissions? Theory and evidence from China
Authors: Lin Xi , Huang Geng , He Ling-Yun 
Published: February 2024

AbstractThe literature investigates trade-environment relationship at the firm level, but does not focus on the environmental effect of trade policy uncertainty. In the context of de-globalization and Sino-US trade friction, trade policy uncertainty significantly increases. How does trade policy uncertainty affect firms’ pollution emissions? In this study, we incorporate energy, pollution, and trade policy uncertainty into Melitz’s (2003) framework and construct a theoretical model to reveal the relationship between trade policy uncertainty and pollution emissions. Then, we employ the event that the USA granted permanent normal trade relationship to China as a quasi natural experiment. We use difference-in-difference-in-difference model and the data of Chinese manufacturing firms for empirical analysis. Our results indicate that the decrease in trade policy uncertainty reduces emission intensity of exporting firms, but has no significant impact on emission levels. Given that these firms do not aggravate emission levels under the condition of expanding output scale, we conclude that the decrease in trade policy uncertainty can improve environmental performance. Mechanism analysis shows an interesting finding that the decrease in trade policy uncertainty reduces emission intensity mainly by improving energy efficiency rather than improving abatement technology and optimizing energy structure. In addition, pollution reductions mainly occur in pollution-intensive and capital-intensive industries as well as coastal regions. Altogether, this study contributes to the literature on trade-environment relationship and trade policy uncertainty.
Multidecadal Variations in the Tropical Western Pacific Driven by Externally‐Forced AMV‐Like Changes
Authors: Qin Minhua , Zhang Renhe , Dai Aiguo , Hua Wenjian 
Published: February 2024

AbstractMultidecadal sea surface temperature (SST) variations in the tropical western Pacific (TWP) have been attributed to nonlinear external forcing and remote influences from the Atlantic Multidecadal Variability (AMV). However, the AMV resulted from both internal variability (IV) and external forcing. Thus, the origins of the TWP SST variations are not well understood. By analyzing observations and model simulations, we show that more than half of the decadal to multidecadal SST variations in TWP during 1920–2020 resulted from external forcing with the forced component correlated with AMV, while the internal component is unrelated to AMV. Furthermore, about 43%–49% of the forced AMV‐like SST variations in TWP result from remote influences of the forced AMV in the Atlantic via atmospheric teleconnection over the North Pacific, with the rest from other remote or local processes.
Marine Heatwaves in the East Asian Marginal Seas Facilitated by Boreal Summer Intraseasonal Oscillations
Authors: Dasgupta Panini , Nam SungHyun , Saranya J. S. , Roxy M. K. 
Published: February 2024

AbstractDuring the summer of 2016, the northern East China Sea and the southern Yellow Sea (NECS‐SYS) experienced one of the most severe and devastating marine heatwaves (MHWs) on record, with a temperature anomaly exceeding 4°C. This shallow semi‐enclosed continental shelf region is widely recognized as a significant hotspot for MHWs with associated incidences of harmful algae blooms. Previous studies have highlighted the importance of mixed layer shoaling as a crucial factor in the genesis of MHWs in the global ocean. The current study employed the Hybrid Coordinate Ocean Model reanalysis data set during 1994–2015 to delve into the mechanisms driving mixed layer shoaling during NECS‐SYS MHW genesis. Our findings reveal the significant role of the northward propagating boreal summer intraseasonal oscillation in promoting MHW genesis and intensification. Specifically, boreal summer intraseasonal oscillation phases 5, 6, and 7 contribute to the favorable conditions that facilitate MHW formation by inducing mixed layer shoaling and increasing solar influx, with mixed layer shoaling playing a more dominant role. The current study provides insights into the relative influences of wind, salinity, and temperature on mixed layer shoaling. We observe that wind plays the most significant role in mixed layer shoaling, followed by temperature and salinity. The boreal summer intraseasonal oscillation induced wind relaxation, increased shortwave radiation, and freshwater influx lead sea surface temperature by 7, 5, and 4 days, respectively. Importantly, mixed layer shoaling leads SST anomalies by 1–2 days. Therefore, the current study also suggests an intraseasonal predictability source for NECS‐SYS MHWs.
Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered
Authors: Ratajczak Mariusz Z. , Ratajczak Janina 
Published: February 2024

AbstractIn single-cell organisms, extracellular microvesicles (ExMVs) were one of the first cell-cell communication platforms that emerged very early during evolution. Multicellular organisms subsequently adapted this mechanism. Evidence indicates that all types of cells secrete these small circular structures surrounded by a lipid membrane that may be encrusted by ligands and receptors interacting with target cells and harboring inside a cargo comprising RNA species, proteins, bioactive lipids, signaling nucleotides, and even entire organelles “hijacked” from the cells of origin. ExMVs are secreted by normal cells and at higher levels by malignant cells, and there are some differences in their cargo. On the one hand, ExMVs secreted from malignant cells interact with cells in the microenvironment, and in return, they are exposed by a “two-way mechanism” to ExMVs secreted by non-leukemic cells. Therefore, leukemogenesis occurs and progresses in ExMVs enriched microenvironments, and this biological fact has pathologic, diagnostic, and therapeutic implications. We are still trying to decipher this intriguing cell-cell communication language better. We will present a current point of view on this topic and review some selected most recent discoveries and papers.
A scoping review on tools and methods for trait prioritization in crop breeding programmes
Authors: Occelli M. , Mukerjee R. , Miller C. , Porciello J. , Puerto S. , Garner E. , Guerra M. , Gomez M. I. , Tufan H. A. 
Published: February 2024

AbstractTrait prioritization studies have guided research, development and investment decisions for public-sector crop breeding programmes since the 1970s, but the research design, methods and tools underpinning these studies are not well understood. We used PRISMA-ScR (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) to evaluate research on trait ranking for major crops over the past 40 years (1980–2023). Data extraction and descriptive analysis on 657 papers show uneven attention to crops, lack of systematic sex disaggregation and regional bias. The lack of standardized trait data taxonomy across studies, and inconsistent research design and data collection practices make cross-comparison of findings impossible. In addition, network mapping of authors and donors shows patterns of concentration and the presence of silos within research areas. This study contributes to the next generation of innovation in trait preference studies to produce more inclusive, demand-driven varietal design that moves beyond trait prioritization focused on productivity and yield.
Sea water temperature and light intensity at high-Arctic subtidal shallows – 16 years perspective
Authors: Moreno Bernabé , Sowa Anna , Reginia Kamil , Balazy Piotr , Chelchowski Maciej , Ronowicz Marta , Kuklinski Piotr 
Published: February 2024

AbstractManifestations of climate change in the Arctic include an increase in water temperatures and massive loss of sea ice enabling more light penetration. Yet to understand tempo and scale of these parameters change over time, constant monitoring is needed. We present 16-yr long-term datasets of sea water temperature and relative light intensity at two depth strata (8 and 14 ± 1 m) of two hard-bottom sites in southern Isfjorden proper (Spitsbergen, 78°N). The high temporal resolution of the datasets (every 30 min, between 2006–2022) makes them suitable for studying changes at a local scale, correlating environmental variability with observed processes in benthic assemblages, and serving as ground-truth for comparison with, for example, remotely sensed or mooring data. These datasets serve as baseline for long-term investigations in the shallows of a high-Arctic fjord undergoing severe environmental changes.