bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEMÓRIAS DE PESSOAS IDOSAS ENCARCERADAS SOBRE O TRABALHO
Authors: Lima Pollyanna Viana , Valença Tatiane Dias Cassemiro , Oliveira Alessandra Souza de , Reis Luciana de Araújo 
Published: October 2023

O estudo tem por objetivo conhecer as memórias de pessoas idosas encarceradas sobre o trabalho. Estudo exploratório e descritivo, com abordagem qualitativa, triangulação de método, fundamentado na Teoria da Memória Coletiva/Social e das Representações Sociais. Realizado em três unidades penais da Bahia com 31 idosos, com 60 anos ou mais, que se encontravam em situação de cárcere. Foram utilizados quatro instrumentos: questionário para coleta de dados nos prontuários de saúde, de assistência social e psicologia; entrevista semiestruturada; grupo focal; e observação não participante com uso de diário de campo. Por meio das memórias, os idosos recordaram sobre o trabalho e declararam ser importante e significativo para suas vidas. Demonstraram ainda a insatisfação por não estarem trabalhando na prisão, sendo este um direito constitucional para todo cidadão recluso que, além de possibilitar a remição da pena e a reinserção na sociedade.
Methods, Detection Rates, and Survival Outcomes of Screening for Head and Neck Cancers
Authors: Sykes Edward A. , Weisbrod Natalie , Rival Ella , Haque Aminul , Fu Rui , Eskander Antoine 
Published: October 2023

ImportanceHead and neck cancers (HNCs) are often diagnosed at advanced clinical stages during their symptomatic phase, leading to a reduced treatment window and poor survival. Screening programs have been suggested as a mitigation strategy.ObjectiveTo examine the effectiveness of current HNC screening programs in improving diagnosis and survival in adults.Evidence ReviewThis Preferred Reporting Items for Systematic Reviews and Meta-analyses–guided systematic review involved use of peer-reviewed, English-language journal articles identified from MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials between January 1, 2001, and July 15, 2022. Snowballing was applied to retrieve more studies. Eligible articles were original clinical trials and observational studies presenting a universal or risk-targeted screening program of primary HNC in the adult population. Reporting quality was assessed using the JBI’s critical appraisal tools.FindingsDatabase searches yielded 3646 unique citations with an additional 8 studies found via snowballing. Five reviewers assessed the full text of 106 studies. Sixteen articles were ultimately included in the review, involving 4.7 million adults (34.1%-100% male; median age, 30-59 years). Fifteen studies were based in Asia and 1 in Europe (Portugal). Five reported data from randomized clinical trials. An oral inspection conducted once or once every 2 to 3 years was described in 11 studies for screening oral cancer, while multistep screening involving Epstein-Barr virus serologic testing for nasopharyngeal carcinoma delivered every 1 to 4 years was presented in 5. In 4 trials and 6 observational studies, screening significantly increased the detection of localized (stage I/II) tumor or was associated with an increased proportion of diagnoses, respectively, regardless of the population and cancer subsites. Universal screening of asymptomatic adults improved 3- to 5-year overall survival but did not increase cancer-specific survival in 4 trials. Targeted screening improved overall and cancer-specific survival or was associated with improved survival outcomes in 2 trials and 2 observational studies, respectively. Studies had low to medium risks of bias.Conclusions and RelevanceEvidence from the existing literature suggests that a risk-targeted screening program for oral and nasopharyngeal cancers could improve diagnosis and patient survival. Screening adherence, societal cost-effectiveness, and optimal risk stratification of such a program warrant future research, especially in low-incidence settings outside Asia.
Marriage of High‐Throughput Gradient Surface Generation With Statistical Learning for the Rational Design of Functionalized Biomaterials
Authors: Fang Zhou , Zhang Meng , Wang Huaiming , Chen Junjian , Yuan Haipeng , Wang Mengyao , Ye Silin , Jia Yong‐Guang , Sheong Fu Kit , Wang Yingjun , Wang Lin 
Published: October 2023

AbstractFunctional biomaterial is already an important aspect in modern therapeutics; yet, the design of novel multi‐functional biomaterial is still a challenging task nowadays. When several biofunctional components are present, the complexity that arises from their combinations and interactions will lead to tedious trial‐and‐error screening. In this work, a novel strategy of biomaterial rational design through the marriage of gradient surface generation with statistical learning is presented. Not only can parameter combinations be screened in a high‐throughput fashion, but also the optimal conditions beyond the experimentally tested range can be extrapolated from the models. The power of the strategy is demonstrated in rationally designing an unprecedented ternary functionalized surface for orthopedic implant, with optimal osteogenic, angiogenic, and neurogenic activities, and its optimality and the best osteointegration promotion are confirmed in vitro and in vivo, respectively. The presented strategy is expected to open up new possibilities in the rational design of biomaterials.
Palladium‐Catalyzed Hydrogenation of Black Barium Titanate for Multienzyme‐Piezoelectric Synergetic Tumor Therapy
Authors: Deng Ruxi , Zhou Hong , Qin Qiaoxi , Ding Li , Song Xinran , Chang Meiqi , Chen Yu , Zhou Yang 
Published: October 2023

AbstractPiezocatalytic tumor therapy is an emerging reactive oxygen species (ROS)‐generating therapeutic approach that relies on piezoelectric polarization under ultrasound (US) irradiation. Optimizing ROS production is a primary objective for enhancing treatment efficiency. In this study, oxygen‐vacancy‐rich Pd‐integrated black barium titanate (BTO) nanoparticles are rationally engineered to boost the ROS generation efficiency via the introduction of Pd. Pd‐catalyzed hydrogenation at low temperatures narrows the bandgap of BTO and reduces the recombination rate of electron‐hole pairs. Furthermore, Pd has dual‐enzyme‐mimicking characteristics, including peroxidase‐ and catalase‐mimicking activities, which further heighten the therapeutic efficacy by enhancing ROS production and reversing the hypoxic tumor microenvironment. Importantly, the dual enzymatic activity of Pd can be amplified by multiple redox processes sparked by the piezoelectric potential under US stimulation, resulting in bilaterally enhanced multienzyme‐piezoelectric synergetic therapy. In vitro and in vivo results confirm high tumor inhibition in murine breast cancer cells. This work stresses the critical effects of defect engineering‐optimized piezodynamic tumor therapy.
Research Progress of Bio‐Based Polybenzoxazine Materials
Authors: Zhou Xuan , Fu Fei , Shen Minggui , Li Qiaoguang , Liu He , Song Zhanqian 
Published: October 2023

AbstractAs a new type of thermosetting resin, polybenzoxazine resin (PBz) has the advantages of flexible molecular design, excellent thermal stability, and mechanical properties. It has application potential in many fields such as aerospace, hydrophobic flame retardant, anti‐corrosion, antibacterial, and electronic communication. Unlike traditional thermosetting resins, PBz can be made with natural renewable resources in addition to petrochemical raw materials. At present, PBz has synthesized monomers from renewable resources and made breakthroughs in raw material sources and performance improvement. In this work, the preparation methods and research progress of bio‐based benzoxazine (BOZ) with different phenol sources and amine sources in the past 10 years are reviewed. The existing shortcomings and improvement methods of PBz functional materials are analyzed, and the future research direction of bio‐based PBz is prospected.
Diagnostic yield of chromosomal microarray in the largest Latino clinical cohort
Authors: Carrillo Yina D. , Rueda‐Gaitán Paula , Gualdrón Orlando , Estrada‐Serrato Carlos , Castro‐Cuesta Taryn A. , Londoño Olga , Rodríguez‐Salazar Luna , Isaza‐Ruget Mario , Arcos‐Burgos Mauricio , López Rivera Juan Javier 
Published: October 2023

AbstractCopy number variants (CNVs) remain a major etiological cause of neurodevelopmental delay and congenital malformations. Chromosomal microarray analysis (CMA) represents the gold standard for CNVs molecular characterization. We applied CMA throughout the patient's clinical diagnostic workup, as the patient's medical provider requested. We collected CMA results of 3380 patients enrolled for 5 years (2016–2021). We found 830 CNVs in 719 patients with potential clinical significance, that is, (i) pathogenic, (ii) likely pathogenic, and (iii) variants of uncertain significance (VUS), from which 10.6% (predominantly involving chromosomes 15 and 22) were most likely the final cause underpinning the patients' clinical phenotype. For those associated with neurodevelopmental phenotypes, the rate of pathogenic or likely pathogenic findings among the patients with CNVs was 60.75%. When considering epileptic phenotypes, it was 59%. Interestingly, our protocol identified two gains harbored in 17q21.31 and 9q34.3, internationally classified initially as VUS. However, because of their high frequency, we propose that these two VUS be reclassified as likely benign in this widely heterogeneous phenotypic population. These results support the diagnostic yield efficiency of CMA in characterizing CNVs to define the final molecular cause of genetic diseases in this cohort of Colombian patients, the most significant sample of patients from a Latino population, and define new benign polymorphic CNVs.
Binding Thermodynamics of Ferrocenyl Ammoniums by Sulfonated Calix[4]arenes
Authors: Wang Qian , Guo Yu , Zhang Hong‐Qing , Wang Kui , Chen Yong , Liu Yu 
Published: October 2023

AbstractThe binding constants (Ka), standard molar enthalpy changes (ΔH°), and entropy changes (TΔS°) between two sulfonated calix[4]arene hosts including rigid p‐sulfonatocalix[4]arene (SC4A) and flexible p‐sulfonatothiacalix[4]arene (STC4A), and three ferrocenyl ammonium guests modified by different aliphatic chains were determined in aqueous solution (pH 7.0 and pH 2.0) by isothermal titration microcalorimetry (ITC). The gained data indicated that for the flexible host STC4A, the host‐guest binding affinities increased with the increase of length of the aliphatic chain of guests whereas the rigid host SC4A behaved almost oppositely. Compared with those at pH 2.0, the binding affinities between the hosts and the guests were much stronger at pH 7.0. This should be attributed to the higher π‐electron density and the extra negative charge of calixarene cavities owing to one of the phenolic hydroxyl groups is deprotonated at pH 7.0, thus affording stronger π⋯π, C−H⋯π and electrostatic interactions. Job plot and ITC confirmed that the molecular binding were stoichiometric 1 : 1 between hosts and guests. NMR experiments showed that the signals of the guest protons with addition of hosts underwent pronounced upfield shifts suggesting the effective binding between hosts and guests. In addition, the molecular selective binding behavior was discussed from the perspective of thermodynamics.
Relationship between the 2D:4D and prenatal testosterone, adult level testosterone, and testosterone change: Meta‐analysis of 54 studies
Authors: Sorokowski Piotr , Kowal Marta 
Published: October 2023

AbstractThe ratio between the hands' second to the fourth finger (2D:4D) is commonly hypothesized to result from prenatal testosterone. The 2D:4D has also been hypothesized to relate to adult‐level testosterone and, more recently, to the testosterone response to a challenging situation. In the present work, we tested these core assumptions. Drawing from, in total, 54 studies and 8077 participants, we investigated whether the 2D:4D is related to adult level testosterone (44 studies), testosterone change (6 studies), and prenatal testosterone (10 studies). We found no evidence of the relationship between the above testosterone types and digit ratios. Furthermore, there was no relationship between testosterone and the right and left 2D:4D, male and female 2D:4D, and the 2D:4D and testosterone measurement (i.e., measured in blood or saliva). However, we found some evidence that prenatal testosterone measured in amniotic fluid (but not cord blood) might be related to the digit ratios—further studies are necessary to validate this observation. In summary, considering the current state of knowledge, any conclusions drawn from the assumption of the digit ratios as the proxy for testosterone (prenatal, adult level, or testosterone change under a challenging situation) warrant great caution.
The endothelial glycocalyx—All the same? No, it is not
Authors: Suzuki Kodai , Miura Tomotaka , Okada Hideshi 
Published: October 2023

AbstractThe endothelial glycocalyx covers the lumen of blood vessels throughout the body and plays an important role in endothelial homeostasis. Advances in electron microscopy techniques have provided clues to better understand the structure and composition of identical vascular endothelial glycocalyx. The morphology and thickness of the endothelial glycocalyx differ from organ to organ. The content of the endothelial glycocalyx covering the vascular lumen differs even in the brain, heart, and lungs, which have the same continuous capillaries. Various types of inflammation are known to attenuate the endothelial glycocalyx; however, we found that the morphology of the glycocalyx damaged by acute inflammation differed from that damaged by chronic inflammation. Acute inflammation breaks the endothelial glycocalyx unevenly, whereas chronic inflammation leads to the overall shortening of the endothelial glycocalyx. The same drug has different effects on the endothelial glycocalyx, depending on the location of the target blood vessels. This difference in response may reflect not only the size and shape of the endothelial glycocalyx but also the different constituents. In the cardiac tissue, the expression of glypican‐1, a core protein of the endothelial glycocalyx, was enhanced. By contrast, in the pulmonary tissue, the expression of heparan sulfate 6‐O‐sulfotransferase 1 and endothelial cell‐specific molecule‐1 significantly increased in the treatment group compared with that in the no‐treatment group. In this review, we present the latest findings on the evolution of the vascular endothelial glycocalyx and consider the microstructural differences.
Synergistic effect of metals and cross linkers on surface modification of iron aluminum oxyhydroxide‐PVA polymer films for enhanced catalytic activity in transesterification reaction
Authors: Binish C. J. , Kopparapu Imam , Vijayasankar A. V. , John Athira Maria , Chundattu Sony J. 
Published: October 2023

AbstractIron‐incorporated aluminum oxyhydroxide polyvinyl alcohol films (Fe‐Al‐PVA) were synthesized using the sol–gel method. The influence of cross‐linking agents on the aluminum oxyhydroxide films was investigated by incorporating glutaraldehyde into the synthesized films. Various characterization techniques were employed to understand the physico‐chemical properties that affect the catalytic and adsorptive behavior of the self‐supported films. The liquid phase transesterification of terpenes was used to test the catalytic activity of the films for the synthesis of industrially important terpene esters. The products were analyzed using GC, GC–MS, and NMR techniques, and optimization studies were carried out under different experimental conditions. The reaction scope was expanded to a wider range of organic compounds, and a possible reaction mechanism was proposed. This study demonstrates the design and modification of efficient bimetallic polymer film catalyst for organic transformations.
Modulare Fußgängerbrücken aus seriell hergestellten Betonfertigteilen
Authors: Rettinger Martin , Prziwarzinski André , Meyer Maximilian , Kolbeck Lothar , Tošić Zlata , Hückler Alex , Lordick Daniel , Borrmann André , Haist Michael , Lohaus Ludger , Schlaich Mike 
Published: October 2023

AbstractModulare Baukonstruktionen ermöglichen die serielle und automatisierte Herstellung von Fertigteilen, welche kontrolliert in einem Fertigteilwerk produziert und anschließend auf der Baustelle in kurzer Zeit montiert werden können. Hierdurch können Herstellungsprozesse weitreichend optimiert und neue Technologien der automatisierten und robotergestützten Fertigung eingesetzt werden. Die Fertigung im Werk verringert Lärm, Staub und Stau auf den Baustellen und durch die Rationalisierung von Prozessen im Fertigteilwerk können Verschnitt‐ und Abfallmengen minimiert und somit Ressourcen eingespart werden. In der vor Witterung geschützten Umgebung können zudem Hochleistungswerkstoffe mit hoher Präzision verarbeitet werden, sodass deren Eigenschaften optimal ausgenutzt werden und eine hohe gleichbleibende Qualität erzielt wird. Von dem planenden Ingenieur verlangt modulares Bauen ein umfassendes Verständnis und die Berücksichtigung der Herstellungsprozesse sowie eine sorgfältige Planung aller Fügestellen des Tragwerks. Das Planungsteam steht vor der Herausforderung, trotz aller Anforderungen durch die Modularisierung, Rationalisierung und Fertigung ein funktionales, dauerhaftes und ästhetisch hochwertiges Bauwerk zu entwerfen. In den in diesem Beitrag vorgestellten Entwurfsstudien stellen sich die Autoren dieser Aufgabe, indem sie Technologien aus aktuellen Forschungsprojekten des modularen Betonbaus in einem einheitlichen Entwurfsszenario einer Fußgängerbrücke anwenden.
Interactions studies of CYP2D6 with quercetin and hyperoside by spectral analysis and molecular dynamics simulations
Authors: Wang Meizi , Wang Suqing , Cui Jingjing , Lian Di , Li Yuan , Du Yutong , Li Li 
Published: October 2023

AbstractSome ingredients from herbal medicine can significantly affect the activity of CYP2D6, thus leading to serious interactions between herbs and drugs. Quercetin and hyperoside are active ingredients widely found in vegetables, fruits, and herbal medicines. Quercetin and hyperoside have many biological activities. In this work, the characteristic bindings of CYP2D6 with quercetin/hyperoside are revealed by multi‐spectroscopy analysis, molecular docking, and molecular dynamics simulations. The fluorescence of CYP2D6 is statically quenched by quercetin and hyperoside. The binding constant (Ka) values of CYP2D6–quercetin/hyperoside range from 104 L mol−1, which indicates that these two flavonoids bind moderately to CYP2D6. Meanwhile, quercetin has a stronger quenching ability to CYP2D6 than that of hyperoside. The secondary structure of CYP2D6 is obviously changed by binding with quercetin/hyperoside. The docking results reveal that the quercetin/hyperoside enters the active site of CYP2D6 near heme and binds to CYP2D6 by hydrogen bonds and van der Waals forces. The molecular dynamics simulation results indicate that the binding of quercetin/hyperoside can stabilize the two complexes, enhance the flexibility of CYP2D6 backbone atoms, and make a more unfolded and looser structure of CYP2D6.
Acute toxic effects of areca nut on central nervous system and liver: A case report
Authors: Mahdavi Mortazavi Seyede Maryam , Ataollahi Maryam , Mashhadiagha Amirali , Moosavi Seyed Ali , Moshfeghinia Reze , Soheili Marzieh 
Published: October 2023

Key Clinical MessageAreca nut (AN) is an addictive substance widely used in different world regions. There are several side effects associated with the use of AN, which have already been reported. However, the reports on hepatotoxicity of AN are sporadic and non‐conclusive. In the present case report, we investigated the hepatotoxicity of AN in a four‐year‐old Iranian girl who was transferred to our medical center with abdominal pain, vomiting, diarrhea, fever, and other symptoms such as hematuria, decreased mental status, multiple seizure episodes. After a comprehensive evaluation, it was concluded that these signs and symptoms were all attributed to AN consumption, which was given by her mother to control diarrhea. Eventually, the patient medical conditions were managed successfully, and she survived by intense medical care. In conclusion, we suggest AN should be considered a potential hepatotoxic agent.
Adsorption of Glucose Molecules on Stainless Steel Enables Ni‐Rich Passivation Film
Authors: Choi Hyebin , An Jaun , Lee Keunyoung , Park Jeongmin , Soo Kim Chung , Lee Seonhong , Kwon Ki‐Young 
Published: October 2023

AbstractStainless steel (SS) is well known for its remarkable versatility. Besides the importance of passivation film for durability and stability of SS, the composition and morphology of passive surface layer have to be precisely modified to create an alloy that is optimal for specific purposes. Herein, we report on the electrochemical preparation of nickel‐enriched passive film which is accomplished by the preferential adsorption of glucose on nickel species among constituents of SS. The presence of nickel‐rich surface and the exposure of nickel on the outmost surface layer participating in surface reactions are verified by monitoring redox couple of Ni2+/Ni3+ as well as elemental analyses (TEM‐Energy‐dispersive X‐ray spectroscopy, X‐ray photoelectron spectroscopy). Reversible interchange of nickel‐rich into iron‐rich surface and vice versa is possible by adding or removing glucose. We find that molecules having more than tri‐dentate of hydroxy groups (e. g. glycerol) is required for the formation of Ni‐rich surface (chelate effect).
Multiplicity‐1 minmax minimal hypersurfaces in manifolds with positive Ricci curvature
Authors: Bellettini Costante 
Published: October 2023

AbstractWe address the one‐parameter minmax construction for the Allen–Cahn energy that has recently lead to a new proof of the existence of a closed minimal hypersurface in an arbitrary compact Riemannian manifold with (Guaraco's work, relying on works by Hutchinson, Tonegawa, and Wickramasekera when sending the Allen–Cahn parameter to 0). We obtain the following result: if the Ricci curvature of N is positive then the minmax Allen–Cahn solutions concentrate around a multiplicity‐1 minimal hypersurface (possibly having a singular set of dimension ). This multiplicity result is new for (for it is also implied by the recent work by Chodosh–Mantoulidis). We exploit directly the minmax characterization of the solutions and the analytic simplicity of semilinear (elliptic and parabolic) theory in . While geometric in flavour, our argument takes advantage of the flexibility afforded by the analytic Allen–Cahn framework, where hypersurfaces are replaced by diffused interfaces; more precisely, they are replaced by sufficiently regular functions (from N to ), whose weighted level sets give rise to diffused interfaces. We capitalise on the fact that (unlike a hypersurface) a function can be deformed both in the domain N (deforming the level sets) and in the target (varying the values). We induce different geometric effects on the diffused interface by using these two types of deformations; this enables us to implement in a continuous way certain operations, whose analogues on a hypersurface would be discontinuous. An immediate corollary of the multiplicity‐1 conclusion is that every compact Riemannian manifold with and positive Ricci curvature admits a two‐sided closed minimal hypersurface, possibly with a singular set of dimension at most . (This geometric corollary also follows from results obtained by different ideas in an Almgren–Pitts minmax framework.)