bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acid‐suppressive medication and incidence of chronic childhood immune‐mediated diseases: A scoping review
Authors: Madej Joanna , Atanassova Tania , McGuire Sarah , Cohen Barrie , Weidner Melissa , Zhang Yingting , Horton Daniel B. 
Published: November 2023

AbstractBackgroundUse of acid‐suppressive medications (ASMs), for example, proton pump inhibitors (PPIs) and histamine‐2 receptor antagonists (H2RAs), has been rising along with the incidence of pediatric immune‐mediated diseases (IMDs). We conducted a scoping review to characterize the literature about prenatal or pediatric exposure to ASMs in relation to incident pediatric IMDs.MethodsElectronic searches were conducted to identify studies from 2001 to 2023 on (a) prenatal or pediatric exposure to PPIs and/or H2RAs and (b) the risk of developing chronic IMDs during childhood. Eligible studies after title/abstract and full‐text screening underwent data abstraction.ResultsOf 26 eligible studies, 11 focused on prenatal ASM exposure and 16 on pediatric exposure. Asthma was the most commonly investigated outcome (16 studies), followed by other allergic diseases (8), eosinophilic esophagitis (3), inflammatory bowel disease (2), and other autoimmune diseases (2). Positive associations between ASM exposure and pediatric IMD outcomes emerged in all but two recent studies, which reported null or negative associations with allergic diseases. The strength of associations was similar across exposure times (prenatal/pediatric), medications (PPIs/H2RAs), and outcomes. Dose–response relationships were often present (7/11 studies). Reported effects by trimester and age of exposure varied. Commonly reported limitations were residual confounding, exposure misclassification, and outcome misclassification.ConclusionIn summary, prenatal or pediatric exposure to PPIs and/or H2RAs has frequently, but not exclusively, been associated with the development of asthma, other allergic diseases, and chronic gastrointestinal IMDs. However, concerns remain about confounding and other sources of bias. Prescribers and families should be aware of these possible risks of ASMs.
Supplementation of media with gamma‐oryzanol as a novel antioxidant to overcome redox imbalance during bovine oocyte maturation in vitro
Authors: Davoodian Najmeh , Kadivar Ali , Mehrban Hossein 
Published: November 2023

AbstractThis study evaluated the effect of supplementing IVM media with γ‐oryzanol (ORY), a nutraceutical derived from rice bran oil, on the development of bovine oocytes and hindering the compromising effect of redox imbalance. An in vitro model of the bovine cumulus‐oocyte complex was used for the evaluation of nuclear maturation and development. Antioxidant activity was investigated by assessing the level of ROS (Reactive Oxygen Species) and GSH (glutathione) in oocytes and quantitative changes in gene expression in matured oocytes and their respective cumulus cells. ORY supplementation increased the proportion of MII oocytes, cleaved embryos, and total blastocysts (p < .05) and was linked to higher and lower levels of intracellular GSH and ROS, respectively (p < .05). The treated oocytes and their respective cumulus‐granulosa cells showed a modulation in the expression of genes related to apoptosis (downregulation of BAX and CHOP) and oxidative stress (upregulation of NRF2, CAT, and SOD). Also, relative upregulation of OCT‐4 and IGF2R in treated oocytes was concomitant with higher subsequent development in terms of cleavage and total blastocyst rates (p < .05). Based on our findings, it appears that ORY supplementation can improve the nuclear maturation and development of bovine oocytes into blastocysts and augment their enzymatic and non‐enzymatic antioxidant systems, maintaining the Redox balance and high enzymatic activity against ROS generation.
Transferring remittances through central banks: A tool applied to the Guatemalan exchange rate
Authors: López‐Marmolejo Arnoldo , Ventosa‐Santaulària Daniel 
Published: November 2023

AbstractCountries where the volume of remittances received represents a significant proportion of their gross domestic product usually face short‐term pressures on their exchange rates that are unrelated to their economic fundamentals. In this article, we analyze how a remittance payment system involving the central banks of the source and destination countries of such remittances could mitigate the pressures on the exchange rate in the receiving country. To quantify the possible effect of such a system, we make an estimate for the case of Guatemala. We also consider the other benefits this system might provide for recipient economies.
How to… support others in developing a career in clinical education research
Authors: Brown Megan E. L. , Samuriwo Ray , Asif Aqua , Da Silva Ana , Vance Gill , Conn Richard 
Published: November 2023

AbstractThe Incubator for Clinical Education Research (ClinEdR) is a UK‐wide network, established with support from the National Institute for Health Research, to lead initiatives to build capacity in the field. A key barrier identified by this group is that many experienced educators, clinicians, and researchers, who may be committed to supporting others, have little guidance on how best to do this. In this “How to …” paper, we draw on relevant literature and our individual and collective experiences as members of the National Institute for Health Research ClinEdR incubator to offer suggestions on how educators can support others to develop successful careers involving ClinEdR. This article offers guidance and inspiration for all professionals whose role involves research and scholarship and who encounter aspiring or developing clinical education researchers in the course of their work. It will also be of interest to researchers who are starting out and progressing in the field.
“They paged me what?”: A transplant infectious disease guide to donor calls
Authors: Gorsline Chelsea A. , Tyler Robert Sean , Sigler Rachel K. , Wolfe Cameron R. , Harris Courtney E. , Kumar Rebecca N. 
Published: November 2023

AbstractDonor‐derived infections in solid organ transplantation can be prevented by risk stratification of donors based on available information, and inquiries surrounding possible or diagnosed infection are common questions posed to transplant infectious disease subspecialists. This article outlines the five key steps in addressing a donor call from a transplant team in a systematic approach, focusing on donor and recipient‐specific factors, transmissibility and treatment of possible infections, and the likelihood of a patient's future organ offers and mortality remaining on the waitlist. These principles are then applied to five donor call cases, in which we review the key takeaway points and supporting literature. These cases can be used as a resource for teaching with trainees.
image
Invasive pulmonary aspergillosis following human metapneumovirus infection in solid‐organ transplant recipients: Another virus to add to the list
Authors: Ramírez‐Sánchez Isabel Cristina , Diaz‐Sanabria Ricardo Augusto , Alza‐Arcila Jhongert 
Published: November 2023

AbstractThere is increasing recognition that respiratory viral infections such as influenza, respiratory syncytial virus, parainfluenza virus, adenovirus, and SARS‐CoV‐2 can promote the development of invasive fungal pulmonary coinfections, particularly invasive aspergillosis, both in immunocompetent and immunocompromised patients. To date, there are no case reports exploring the role of human metapneumovirus as a risk factor for fungal coinfection. Below, we describe the case of a 63‐year‐old woman who received a kidney transplant and developed invasive pulmonary aspergillosis after a human metapneumovirus infection and discuss the possible phenomena that could favor this association
An experimental study of consecutive administration of ropinirole and apomorphine for emesis induction in dogs
Authors: Saloranta Lasse I. , Levijoki Jouko M. , Vuorela Arja M. 
Published: November 2023

AbstractObjectiveTo study the safety and effectiveness of consecutively administered ropinirole and apomorphine (both dopamine 2‐like receptor agonists) for emesis induction in dogs.DesignProspective, crossover study design.SettingInstitutional animal research facility.AnimalsSix healthy male purpose‐bred Beagle dogs.InterventionsEach dog received 4 treatments: (1) apomorphine infusion (21 μg/kg) over 30 minutes + ropinirole eye drops (3.75 mg/m2); (2) ropinirole infusion (108 μg/m2) over 30 minutes + apomorphine SC (100 μg/kg); (3) apomorphine SC (100 μg/kg) + ropinirole eye drops (7.5 mg/m2) after 30 minutes; and (4) ropinirole eye drops (7.5 mg/m2) + apomorphine SC (100 μg/kg) after 30 minutes. Infusions were administered via a catheter instrumented in the cephalic vein. Eye drops and SC injections were administered as described in the product inserts. Blood samples were taken for ropinirole and apomorphine concentration analysis before dosing and periodically following administrations. The washout period between the treatments was 5–7 days.Measurements and Main ResultsNumber of vomits and clinical signs were recorded. Alertness and heart rate were monitored in conjunction with blood sampling. The average number of vomits varied between 4.3 and 8.8 (range 1–16) following treatments. Signs of nausea, vomiting, and lethargy were seen in all individuals without significant differences between treatments. Moderate to marked, transient increase in heart rates was detected in all treatments. Infrequent noted side effects included ocular hyperemia, blepharospasms, and muscle tremors. Prior treatment with apomorphine significantly decreased the absorption of ropinirole eye drops.ConclusionsThe safety and efficacy profiles of this experimental study support that ropinirole and apomorphine could be administered consecutively in cases where the treatment using 1 substance has resulted in an incomplete evacuation of the stomach contents, and the attending veterinarian considers the use of a different agent to have benefits that outweigh the risks.
Assessment of novel hybrid treatment wetlands as nature‐based solutions for pharmaceutical industry wastewater treatment
Authors: Al‐Mashaqbeh Othman , Alsalhi Layal , Salaymeh Lana , Lyu Tao 
Published: November 2023

AbstractThis study investigated the use of nature‐based solutions for treating real pharmaceutical industry wastewater in Jordan. A pilot‐scale hybrid treatment wetland (TW) equipped with local zeolite was employed, comprising a tidal flow TW and a horizontal subsurface flow TW. This system was efficient in treating pharmaceutical wastewater with removal efficiencies of 61.4%, 52.6%, 60.1%, and 61.9% for chemical oxygen demand, total phosphorus, total nitrogen, and NH4+‐N, respectively. The final effluent met Jordanian standards for the reuse of treated wastewater in irrigation (Class B). Five pharmaceuticals, namely, enrofloxacin, ciprofloxacin, ofloxacin, lincomycin, and trimethoprim, demonstrated nearly completed removal (93.6–99.9%). Moderated removal performances (59.2–68.2%) were observed for two compounds, flumequine and sulfaquinoxaline. However, three pharmaceuticals, namely, carbamazepine, diclofenac, and sulfadimidine, showed limited removal performances (1.1–20.5%). This study supported the feasibility of using nature‐based solutions for treating pharmaceutical wastewater and highlighted that future studies are required to optimize this strategy for removing a broader range of pharmaceuticals.
Nurses’ experiences and perceptions of unfinished nursing care: a qualitative systematic review protocol
Authors: Yang Li , Zhou Wen , Gao Yan , Wu Taiqin , Zhang Huan , Gan Xiuni 
Published: November 2023

Objective:
The aim of this review is to synthesize the findings of qualitative studies about the experiences and perceptions of nurses regarding unfinished nursing care.

Introduction:
The issue of unfinished nursing care is a widespread challenge globally, causing detrimental effects to both patients and health care practitioners. Despite its prevalence, there is a dearth of qualitative evidence synthesis summarizing the reasons for unfinished nursing care, as well as the experiences of nurses.

Inclusion criteria:
This review will include studies exploring registered nurses’ and nurse managers’ experiences and perceptions of unfinished nursing care, utilizing qualitative methods. Our approach to qualitative methodology will be unrestricted, allowing for various designs, such as phenomenology, ethnography, grounded theory, action research, and feminist research. Only articles published in English or Chinese from 2001 onward will be included.

Methods:
Our search will encompass the following electronic databases for published and unpublished literature: MEDLINE (PubMed), PsycINFO (APA PsycNET), CINAHL (EBSCOhost), Web of Science, Embase, ScienceDirect, ProQuest Dissertations and Theses, GreyNet International, Google Scholar, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Chinese Biomedicine Literature Database (CBM). To ensure thoroughness, manual searches of reference lists and citations of included studies will also be conducted. Two reviewers will extract relevant information, and quality validation will be conducted using the JBI critical appraisal checklist for qualitative research. Similar findings will be categorized through meta-aggregation to establish synthesized findings. Finally, each synthesized finding will be graded according to the JBI ConQual approach.

Review registration:
PROSPERO CRD42022368041
Mitochondrial phosphagen kinases support the volatile power demands of motor nerve terminals
Authors: Justs Karlis A. , Sempertegui Sergio , Riboul Danielle V. , Oliva Carlos D. , Durbin Ryan J. , Crill Sarah , Stawarski Michal , Su Chenchen , Renden Robert B. , Fily Yaouen , Macleod Gregory T. 
Published: November 2023

AbstractMotor neurons are the longest neurons in the body, with axon terminals separated from the soma by as much as a meter. These terminals are largely autonomous with regard to their bioenergetic metabolism and must burn energy at a high rate to sustain muscle contraction. Here, through computer simulation and drawing on previously published empirical data, we determined that motor neuron terminals in Drosophila larvae experience highly volatile power demands. It might not be surprising then, that we discovered the mitochondria in the motor neuron terminals of both Drosophila and mice to be heavily decorated with phosphagen kinases ‐ a key element in an energy storage and buffering system well‐characterized in fast‐twitch muscle fibres. Knockdown of arginine kinase 1 (ArgK1) in Drosophila larval motor neurons led to several bioenergetic deficits, including mitochondrial matrix acidification and a faster decline in the cytosol ATP to ADP ratio during axon burst firing.
imageKey points
Neurons commonly fire in bursts imposing highly volatile demands on the bioenergetic machinery that generates ATP.
Using a computational approach, we built profiles of presynaptic power demand at the level of single action potentials, as well as the transition from rest to sustained activity.
Phosphagen systems are known to buffer ATP levels in muscles and we demonstrate that phosphagen kinases, which support such phosphagen systems, also localize to mitochondria in motor nerve terminals of fruit flies and mice.
By knocking down phosphagen kinases in fruit fly motor nerve terminals, and using fluorescent reporters of the ATP:ADP ratio, lactate, pH and Ca2+, we demonstrate a role for phosphagen kinases in stabilizing presynaptic ATP levels.
These data indicate that the maintenance of phosphagen systems in motor neurons, and not just muscle, could be a beneficial initiative in sustaining musculoskeletal health and performance.
A Review of Prospects and Opportunities in Disassembly With Human–Robot Collaboration
Authors: Lee Meng-Lun , Liang Xiao , Hu Boyi , Onel Gulcan , Behdad Sara , Zheng Minghui 
Published: November 2023

Abstract
Product disassembly plays a crucial role in the recycling, remanufacturing, and reuse of end-of-use (EoU) products. However, the current manual disassembly process is inefficient due to the complexity and variation of EoU products. While fully automating disassembly is not economically viable given the intricate nature of the task, there is potential in using human–robot collaboration (HRC) to enhance disassembly operations. HRC combines the flexibility and problem-solving abilities of humans with the precise repetition and handling of unsafe tasks by robots. Nevertheless, numerous challenges persist in technology, human workers, and remanufacturing work, which require comprehensive multidisciplinary research to address critical gaps. These challenges have motivated the authors to provide a detailed discussion on the opportunities and obstacles associated with introducing HRC to disassembly. In this regard, the authors have conducted a review of the recent progress in HRC disassembly and present the insights gained from this analysis from three distinct perspectives: technology, workers, and work.
Data-Driven Discovery of Lithium-Ion Battery State of Charge Dynamics
Authors: Rodriguez Renato , Ahmadzadeh Omidreza , Wang Yan , Soudbakhsh Damoon 
Published: November 2023

Abstract
We present a physics-inspired input/output predictor of lithium-ion batteries (LiBs) for online state-of-charge (SOC) prediction. The complex electrochemical behavior of batteries results in nonlinear and high-dimensional dynamics. Accurate SOC prediction is paramount for increased performance, improved operational safety, and extended longevity of LiBs. The battery's internal parameters are cell-dependent and change with operating conditions and battery health variations. We present a data-driven solution to discover governing equations pertaining to SOC dynamics from battery operando measurements. Our approach relaxes the need for detailed knowledge of the battery's composition while maintaining prediction fidelity. The predictor consists of a library of candidate terms and a set of coefficients found via a sparsity-promoting algorithm. The library was enhanced with explicit physics-inspired terms to improve the predictor's interpretability and generalizability. Further, we developed a Monte Carlo search of additional nonlinear terms to efficiently explore the high-dimensional search space and improve the characterization of highly nonlinear behaviors. Also, we developed a hyperparameter autotuning approach for identifying optimal coefficients that balance accuracy and complexity. The resulting SOC predictor achieved high predictive performance scores (RMSE) of 2.2×10−6 and 4.8×10−4, respectively, for training and validation on experimental results corresponding to a stochastic drive cycle. Furthermore, the predictor achieved an RMSE of 8.5×10−4 on unseen battery measurements corresponding to the standard US06 drive cycle, further showcasing the adaptability of the predictor and the enhanced modeling approach to new conditions.
A Digital Twin–Based Environment-Adaptive Assignment Method for Human–Robot Collaboration
Authors: Ma Xin , Qi Qinglin , Tao Fei 
Published: November 2023

Abstract
Human–robot collaboration, which strives to combine the best skills of humans and robots, has shown board application prospects in meeting safe–effective–flexible requirements in various fields. The ideation of much closer interaction between humans and robots has greatly developed the exploration of digital twin to enhance collaboration. By offering high-fidelity models and real-time physical–virtual interaction, the digital twin enables to achieve an accurate reflection of the physical scenario, including not only human–robot conditions but also environmental changes. However, the appearance of unpredictable events may cause an inconsistency between the established schedule and actual execution. To cope with this issue, an environment-adaptive assignment method based on digital twin for human–robot collaboration is formed in this study. The proposed approach consists of a factor–event–act mechanism that analyzes the dynamic events and their impacts from both internal and external perspectives of digital twin and a genetic algorithm–based assignment algorithm to respond to them. Experiments are carried out in the last part, aiming to show the feasibility of the proposed method.
Calcineurin is required for
Candida glabrata
Pdr1 transcriptional activation
Authors: Vu Bao Gia , Simonicova Lucia , Moye-Rowley W. Scott 
Published: November 2023

ABSTRACT

Fluconazole is one of the most commonly used antifungals today. A result of this has been the inevitable selection of fluconazole-resistant organisms. This is an especially acute problem in the pathogenic yeast
Candida glabrata
. Elevated minimal inhibitory concentrations for fluconazole in
C. glabrata
are frequently associated with substitution mutations within the Zn2Cys6 zinc cluster-containing transcription factor-encoding gene
PDR1
. These mutant Pdr1 regulators drive constitutively high expression of target genes like
CDR1
that encodes an ATP-binding cassette transporter thought to act as a drug efflux pump. Exposure of
C. glabrata
to fluconazole induced expression of both Pdr1 and
CDR1
, although little is known of the molecular basis underlying the upstream signals that trigger Pdr1 activation. Here, we show that the protein phosphatase calcineurin is required for fluconazole-dependent induction of Pdr1 transcriptional regulation. Calcineurin catalytic activity is required for normal Pdr1 regulation, and a hyperactive form of this phosphatase can decrease susceptibility to the echinocandin caspofungin but does not show a similar change for fluconazole susceptibility. Loss of calcineurin from strains expressing two different gain-of-function forms of Pdr1 also caused a decrease in
CDR1
expression and increased fluconazole susceptibility, demonstrating that even these hyperactive Pdr1 regulatory mutants cannot bypass the requirement for calcineurin. Our data implicate calcineurin activity as a link tying azole and echinocandin susceptibility together via the control of transcription factor activity.

IMPORTANCE

Drug-resistant microorganisms are a problem in the treatment of all infectious diseases; this is an especially acute problem with fungi due to the existence of only three major classes of antifungal drugs, including the azole drug fluconazole. In the pathogenic yeast
Candida glabrata
, mutant forms of a transcription factor called Pdr1 are commonly associated with decreased fluconazole susceptibility and poor clinical outcomes. Here, we identify a protein phosphatase called calcineurin that is required for fluconazole-dependent induction of Pdr1 transcriptional activation and associated drug susceptibility. Gain-of-function mutant forms of Pdr1 still required the presence of calcineurin to confer normally decreased fluconazole susceptibility. Previous studies showed that calcineurin controls susceptibility to the echinocandin class of antifungal drugs, and our data demonstrate that this protein phosphatase is also required for normal azole drug susceptibility. Calcineurin plays a central role in susceptibility to two of the three major classes of antifungal drugs in
C. glabrata
.
Identification of virulence factors and antibiotic resistance in
Salmonella enterica
subsp. enterica serovar Javiana (FARPER-220) isolated from broiler chickens
Authors: Tataje-Lavanda Luis , Villanueva-Pérez Doris , Montalván-Avalos Angela , Vallejos-Sánchez Katherine , Zimic-Peralta Mirko , Fernández-Sánchez Manolo , Fernández-Díaz Manolo 
Published: November 2023

ABSTRACT

Genome sequencing of highly virulent
Salmonella enterica
subsp. enterica serovar Javiana strain FARPER-220 (ST-1674) isolated from broiler chickens in Peru revealed multiple virulence factors, antibiotic resistance genes, and invasion-related subcategories. The results provide insights into the potential importance of this strain in causing infections in various animals.