bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peak study: A phase 3, randomized, open-label multicenter clinical study of bezuclastinib (CGT9486) and sunitinib in combination versus sunitinib in patients with gastrointestinal stromal tumors (GIST).
Authors: Heinrich Michael C. , Somaiah Neeta , Trent Jonathan C. , Wilky Breelyn A. , Burgess Melissa Amber , Singh Arun S. , Attia Steven , Agulnik Mark , Tap William D. , Bauer Sebastian , Jones Robin Lewis , Serrano Cesar , Zou Liangxing , Moynihan Kevin , Lawrence Julia , Wagner Andrew J. 
Published: January 2024

TPS766 Background: Imatinib is the worldwide standard for first-line therapy of advanced KIT-mutant GIST. However, secondary resistance mutations in the KIT ATP-binding domain (exons 13, 14), activation loop (exons 17, 18), or both develop and result in loss of imatinib-sensitivity. While no single tyrosine kinase inhibitor (TKI) inhibits all KIT mutations, the combination of bezuclastinib + sunitinib targets commonly occurring primary (exons 9, 11) and secondary (exons 13, 14, 17, and 18) KIT mutations. In a Phase 1/2 clinical study, pts with relapsed and/or refractory GIST and a median of 3 prior lines of therapy treated with bezuclastinib + sunitinib (n=15) experienced clinical benefit and an acceptable safety profile, warranting further evaluation in a randomized trial. Methods: Peak (NCT05208047) is a global, randomized, open-label, multi-part Phase 3 study evaluating the efficacy and safety of bezuclastinib + sunitinib versus sunitinib as second-line treatment in adult pts who were intolerant to imatinib or whose tumors had imatinib-resistance. The lead-in portion, to test a new formulation of bezuclastinib, (Part 1) has completed enrollment. Based upon PK and safety, a dose of bezuclastinib 600 mg QD + sunitinib 37.5 mg QD has been determined for Part 2 of the Peak study. Part 2 will enroll ~388 pts to be randomized (1:1) to bezuclastinib 600 mg QD + sunitinib 37.5 mg QD or sunitinib 37.5 mg QD alone. Key inclusion: >1 measurable lesion per modified Response Evaluation Criteria in Solid Tumors (mRECIST) v1.1, Eastern Cooperative Oncology Group Performance Status 0-2, adequate organ function, and prior imatinib therapy (no other prior therapy). Key exclusion: PDGFR mutations or succinate dehydrogenase deficiency, clinically significant cardiac disease, and use of strong CYP3A4 inhibitors or inducers. The primary endpoint is progression-free survival (PFS) confirmed by blinded independent central review per mRECIST v1.1. Additional efficacy (including overall survival and objective response rate) and safety endpoints will be evaluated. Clinical trial information: NCT05208047 .
Controlled expression of avian pre-migratory fattening influences indices of innate immunity
Authors: Tobolka Marcin , Zielińska Zuzanna , Fusani Leonida , Huber Nikolaus , Maggini Ivan , Pola Gianni , Marasco Valeria 
Published: January 2024

ABSTRACT
While immunity is frequently dampened when birds engage in strenuous migratory flights, whether and how immunity changes during the rapid accumulation of energy stores in preparation for migration remains largely unknown. Here we induced pre-migratory fattening through controlled changes of daylight in common quails (Coturnix coturnix) and regularly assessed changes in three markers of constitutive innate immunity (leukocyte coping capacity or LCC, hemagglutination and hemolysis titres) and measures of body composition (lean and fat mass). All the three markers showed similar changes over the pre-migratory fattening process. LCC responses, hemagglutination titres, and hemolysis titres, were on average higher in the mid-fattening phase compared to the peak-fattening phase, when values were similar to those observed prior the start of pre-migratory fattening. At mid-fattening, we found that the birds that showed a larger accumulation of fat mass (as % of body mass) had lower LCC peak responses and hemolysis titres. Reversibly, at mid-fattening, we also found that the birds that kept a higher proportion of lean mass (as % of body mass) had the highest LCC peaks. Our results indicate that migratory birds undergo changes in immune indices (over 8 weeks) as they accumulate energy stores for migration and propose that this could be due to competing or trade-off processes between metabolic remodelling and innate immune system function.
Survey of antibodies to Peste des petits ruminants virus in small ruminants in the Mediterranean Region of Turkey
Authors: Şevik M 
Published: January 2024

Peste des petits ruminants (PPR) is a viral disease affecting sheep and goats caused by peste des petits ruminants virus (PPRV) has a serious economic impact due to the restrictions on animal trade and animal movements and high mortality rates in small ruminant populations. The common clinical sings of the PPR are fever, muco-purulent nasal discharge, diarrhoea and abortion. Seroepidemiological studies of PPRV infection in sheep and goats in Turkey are scant. Therefore, this study was aimed to evaluate the seroprevalence of PPR in small ruminants in Turkey. Ovine blood samples were collected by random sampling method from sheep (n = 77) and goats (n = 61) from unvaccinated flocks (n = 40) in the Antalya Province in the Mediterranean region of Turkey. A competitive enzyme-linked immunosorbent assay (c-ELISA) kit was used to detect antibodies against PPRV in sera samples. Out of 138 sera samples analysed, eighteen sera samples (13%, 95% CI: 7.4 - 18.7) were PPRV seropositive, of which 18.2% (95% CI: 9.6 - 26.8; 14/77) were from sheep, whereas 6.6% (95% CI: 0.3 - 12.8; 4/61) were from goats. Although PPRV seropositivity rate was higher in sheep than goats, it was not statistically significant (P = 0.07). PPRV seropositivity was higher in small ruminants older than 24 months (19.4%) compared with less than or equal to 24 months (7%) (P = 0.04). Although, there was no statistically significant difference between sexes, PPRV seropositivity rate was higher (14.5%) in females than males (10.9%) (P = 0.61). The flock-level seroprevalence was 30% (12/40). The result of the present study showed that seroprevalence of PPRV infection is high in sheep and goats in the Antalya Province. However, results of the study are not enough to determine the regional and country-based profile of the PPRV infection in Turkey. Further epidemiological studies are required to get more epidemiology data on PPR in Turkey.
Presence of genes encoding aminoglycoside-modifying enzyme (AME) and virulence factors in high-level aminoglycoside-resistant (HLAR) Enterococcus strains isolated from retail chicken meat in Turkey
Authors: Yalçın M , Özden Tuncer B , Akpınar Kankaya D , Tuncer Y 
Published: January 2024

In this study, the presence of aminoglycoside-modifying enzyme (AME) and virulence factor genes were investigated in previously isolated 32 high-level aminoglycoside-resistant (HLAR) Enterococcus strains isolated from retail chicken meat in Turkey. At least one AME-encoding gene was detected in HLAR enterococci by polymerase chain reaction (PCR). The ant(6ʹ)-Ia was identified as the most prevalent (87.5%, 28/32) AME gene. The aph(3ʹ)-IIIa (78.13%, 25/32), ant(4ʹ)-Ia (68.75%, 22/32), aph(2ʹʹ)-Ib (62.5%, 20/32), aac(6ʹ)-Ie-aph(2ʹʹ)-Ia (21.88%, 7/32) and aph(2ʹʹ)-Ic (9.38%, 3/32) are the other detected AME-encoding genes in strains. The aph(2ʹʹ)-Id was found in none of the HLAR strains. The aph(2ʹʹ)-Ib and ant(6ʹ)-Ia were identified as the most frequently AME-encoding genes in high-level gentamicin-resistant (HLGR) and high-level streptomycin-resistant (HLSR) strains, respectively. Among the 32 HLAR strains, only E. faecalis MSE61.1 and E. avium MSE63.1 were found capable of hydrolyzing gelatine. All HLAR strains showed α-hemolytic activity except E. durans MG13.4 and E. casseliflavus MGM111.1, which were exhibited β- and γ-hemolytic activity, respectively. It was determined that all HLAR strains, except E. durans MGE13.1 and MGE63.1, contain at least one virulence factor gene. The efaAfm (87.5%, 28/32), acm (65.63%, 21/32) and gelE (37.5%, 12/32) were found to be the most prevalent virulence factor genes. HLAR enterococci strains that have the virulence factor genes may pose a risk to consumer health.
Effects of Suaeda rigida extract on the growth performance, antioxidant capacity and immune function of Karakul sheep
Authors: Sha A , Liu Y , Hao H 
Published: January 2024

The objectives of this study were to investigate the effects of dietary supplementation of Suaeda rigida extract on the growth performance, antioxidant capacity and immune function of Karakul sheep. Blood samples were collected from the jugular veins before morning feeding on the 10th, 20th and 30th days of the trial period, respectively, and the serum antioxidant and immune indexes of Karakul sheep in the control and experimental groups were determined. The results showed that the growth performance of Karakul sheep was dramatically improved by dietary supplementation of Suaeda rigida, the contents of NO, cGMP, MDA, H2O2, •OH and the activities of XOD, GGT, NOS in the serums of Karakul sheep were inhibited to varying degrees, the GSH content and the activities of GSH-Px, GST, CAT and SOD were substantially increased (P<0.05 at 10d, P<0.01 both 20d and 30d). At 30 days, the contents of total protein, globulin, calcium and three immunoglobulins including IgG, IgA, IgM in the sera of experimental Karakul sheep were significantly higher than those in the control group (P<0.05). All the results suggested that the growth performance, antioxidant, anti-aging capacity, immune function, and life extension of Karakul sheep were significantly improved by dietary supplementation with Suaeda rigida.
Some Meat Quality Traits and Fatty Acid Composition of Saanen, Turkish Hair × Saanen (F1 ) and Honamlı × Saanen (F1 ) Crossbreed Kids
Authors: Akbaş AA , Kuleaşan Ş , Üstüner H , Elmaz Ö , Sarı M , Saatcı M 
Published: January 2024

The study was aimed to investigate the possibilities of obtaining slaughtered kids using indigenous breeds in Saanen flocks, which does not require breeding. The cross-sectional surface of the Musculus longissimus dorsi (MLD) muscle was used to evaluate the some meat quality parameters. Evaluations were made after slaughtering and at 24th hour and on 7th day after the slaughtering. The average values of pH, pH 24, cooking loss, water holding capacity and shear force values obtained in research groups were 6.46, 5.02, 24.58%, 3.25% and 3.67 kg / cm2 in Honamlı x Saanen; In the same order, 6.46, 5.69, 25.66%, 5.59% and 4.52 kg / cm2 in Saanen and 6.62, 5.27, 22.69%, 2.55% and 4.25 kg / cm2, in the Turkish Hair x Saanen (F1) respectively. It was found in the study that L0 (brightness), a0 (redness) and b0 (yellowness) values were 47.50, 7.51 and 12.67 for Honamlı x Saanen crossbred kids, respectively. The same values were 48.34, 7.74, and 12.62 for Saanen kids and 47.73, 8.01, and 13.20 for Turkish Hair x Saanen crossbred kids, respectively. In the study, the amount of muscle fat in Turkish Hair x Saanen (F1) crossbred kids was found 2.85%. While there was no difference in oleic acid content among genotypes, the ω-6 fatty acids linoleic and arachidonic were detected in the Saanen kids with a maximum of 10.67% and 4.98%, respectively (P< 0.05). According to findings, It was found that Honamlı x Saanen (F1) cross kids have shown beter performance for many traits than others. Therefore, Saanen farms which has no need young breeding animal can use Honamlı bucks as patternal line for the butchered kid production. This application can be introduced to the sector.
Effects of Somatotropic Axis Gene Polymorphisms on Milk Yields in Simmental Cattle
Authors: Sonmez Z , Kopuzlu S , Özdemir M 
Published: January 2024

Due to the increasing world population, scientists aim to obtain high-yield products using new techniques and methods to meet needs in the fields of food, agriculture, and livestock. It is very important to selected the candidate genes and markers correctly, especially in the QTL and MAS techniques in livestock. Somatotropic axis genes affect yield traits, growth, reproduction, and milk production in cattle. In the study, we determined GH/AluI and IGFI/SnaBI gene polymorphisms using the PCR-RFLP technique in DNA samples obtained from 70 Simmental cattle. The allele frequencies of the genes were in the same proportion as 0.62 and 0.38, L and V for the GH gene and T and C for the IGFI gene. There was no significant relationship between the polymorphic genotypes of the genes we examined and lactation milk yields, 305-day milk yields, daily milk yields, and lactation periods of Simmental cattle. The probability of using bGH/AluI and IGFI/SnaBI genetic variations as markers in association studies with milk yield in cattle is extremely low.
Keywords: Axis genes; RFLP; MAS; Simmental; milk yield
The role of female leadership in times of financial crisis – an analysis during the COVID-19 pandemic
Authors: Sinha Tanja 
Published: January 2024

In 2020 the new COVID-19-virus brought an external shock to the stock markets. In this situation effective leadership was essential to bring companies through the crisis.
Political observation showed that countries led by women managed the pandemic situation more effectively than those led by men. Therefore, the research objective of this article is to examine whether female leaders were also more successful to guide companies through the pandemic. Success in this study is defined as financial performance based on stock prices.
To find out whether female managers showed a better financial performance during this crisis, this study examined all companies listed on the German Stock Exchange, which have at least 50 % women in the board. To compare this female managed companies to firms managed mainly by male managers, a market value weighted index for the female managed companies was conducted and compared to the German Stock Index DAX by looking at several financial key figures.
The analysis of these key figures shows that female managed companies outperformed male managed companies in terms of return as well as risk in the year of the COVID-pandemic but were not able to keep their overperformance in the subsequent years. This may be an indicator that women are superior in leading a company through a crisis but suffer in terms of performance when times have calmed down.
How, and why, science and health researchers read scientific (IMRAD) papers
Authors: Shiely Frances , Gallagher Kerrie , Millar Seán R. 
Published: January 2024

Objectives
The purpose of our study was to determine the order in which science and health researchers read scientific papers, their reasons for doing so and the perceived difficulty and perceived importance of each section.

Study design and setting
An online survey open to science and health academics and researchers distributed via existing research networks, X (formerly Twitter), and LinkedIn.

Results
Almost 90% of respondents self-declared to be experienced in reading research papers. 98.6% of the sample read the abstract first because it provides an overview of the paper and facilitates a decision on continuing to read on or not. Seventy-five percent perceived it to be the easiest to read and 62.4% perceived it to be very important (highest rank on a 5-point Likert scale). The majority of respondents did not read a paper in the IMRAD (Introduction, Methods, Results And Discussion) format. Perceived difficulty and perceived importance influenced reading order.

Conclusion
Science and health researchers do not typically read scientific and health research papers in IMRAD format. The more important a respondent perceives a section to be, the more likely they are to read it. The easier a section is perceived, the more likely it will be read. We present recommendations to those teaching the skill of writing scientific papers and reports.
Study on the positivity rate and influencing factors of anxiety in pregnant women during the first fetal magnetic resonance examination: A cross-sectional study
Authors: Zheng Yuping , Wang Yun , Liu Xue , Zhang Li , Zhang Hui , Liu Juan , Liu Yang , Li Xuesheng , Ning Gang 
Published: January 2024

Objective
This study investigated the positive rate and related influencing factors of anxiety screening in pregnant women during the first fetal magnetic resonance examination.

Methods
A total of 303 pregnant women who met the criteria for magnetic resonance pregnancy examination in a Grade III maternity hospital from December 2021 to December 2022 were included by the convenience sampling method. A cross-sectional survey was conducted before the examination using the General Situation Questionnaire and Self-rating Anxiety Scale (SAS).

Results
The positive rate of anxiety was 31.02% (94/303), and the average score of anxiety was 45.71±9.84. Univariate analysis results showed that age, educational level, occupation, place of residence, per capita monthly income, and number of pregnancies were related to the anxiety status of pregnant women in the fetal magnetic resonance examination (P<0.05). The results of logistic regression analysis showed that the factor of college degree [OR: 2.168, 95% CI: (1.119, 4.273)] in the classification of cultural level and country factor [OR: 2.162, 95% CI: (1.066, 4.385)] in the classification of place of residence had an impact on the anxiety score of pregnant women in the fetal magnetic resonance examination (P<0.05).

Conclusions
The positive rate of anxiety screening of pregnant women before the first prenatal magnetic resonance examination is high. A low education level and living in the countryside will increase the probability of anxiety in pregnant women during magnetic resonance examination. Based on the above research results, it is suggested that medical institutions pay attention to the mental health of pregnant women, improve mental health care services, and reduce the adverse psychological problems caused by prenatal examination.
Belle Park Pluriverses
Authors: Murray Laura J. 
Published: January 2024

Belle Park was established in 1973 in Kingston, Ontario, on a former landfill built on a wetland. Over the past three years, the SSHRC-funded Belle Park Project has been employing Research-Creation and community and interdisciplinary collaboration to engage with this small but highly complex space, whose most prominent feature is a totem pole carved by incarcerated Indigenous men in a local prison. The land is contaminated, but despite this the park is a rich natural habitat, and it is also the location of an encampment of unhoused people. Many existing models of harm and resistance do not capture the frictions and possibilities we experience in this site. “Belle Park Pluriverses” offers poetry and found poetry, along with photographs, to reveal and trouble binaries such as wild v. domestic, dry v. wet, beautiful v. ugly, care v. neglect, garbage v. means of life.
Photos by Dorit Naaman and Laura J. Murray.
กลยุทธ์การปรับตัววิถีใหม่เพื่อความอยู่รอดในการดำเนินงานของผู้ประกอบการธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน
Authors:   นักศึกษามหาบัณฑิต สาขาวิชาคหกรรมศาสตร์ คณะเทคโนโลยีคหกรรมศาสตร์ มหาวิทยาลัยเทคโนโลยีราชมงคลพระนคร, ขุทะกะพันธุ์ พัชรินทร์ , กี่อาริโย ชญาภัทร์ ,   ผู้ช่วยศาสตราจารย์ ดร.ประจำหลักสูตร สาขาวิชาคหกรรมศาสตร์ คณะเทคโนโลยีคหกรรมศาสตร์ มหาวิทยาลัยเทคโนโลยีราชมงคลพระนคร
Published: January 2024

การศึกษาวิจัยมีวัตถุประสงค์เพื่อ 1) ศึกษาสภาพการดำเนินงานของผู้ประกอบการธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน 2) ปัจจัยภายในและภายนอกที่เกี่ยวข้องกับการดำเนินงานของผู้ประกอบการธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน 3) ศึกษากลยุทธ์การปรับตัววิถีใหม่เพื่อความอยู่รอดในการดำเนินงานของผู้ประกอบการธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน 4) เปรียบเทียบกลยุทธ์การปรับตัววิถีใหม่เพื่อความอยู่รอดในการดำเนินงานของผู้ประกอบการธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน จำแนกตามสภาพการดำเนินงาน และ 5) หาความสัมพันธ์ระหว่างกลยุทธ์การปรับตัววิถีใหม่เพื่อความอยู่รอดในการดำเนินงานของผู้ประกอบการธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน กับปัจจัยภายในและปัจจัยภายนอกที่เกี่ยวข้องกับการดำเนินธุรกิจ ประชากรคือ เจ้าของธุรกิจ ผู้บริหาร ผู้จัดการ หัวหน้างาน พนักงานของร้านอาหาร จำนวน 50 ราย และผู้บริโภคที่เลือกใช้บริการของร้านอาหารไทยสตีฟ คาเฟ่ แอนด์ ครุยซีน จำนวน 3 สาขา ในเขตกรุงเทพมหานคร ได้แก่ สาขาเทเวศร์ สาขาพระราม 6 และสาขาผ่านฟ้า จำนวน 350 คน เครื่องมือที่ใช้ในการวิจัย คือ แบบสอบถาม สถิติที่ใช้ในการวิเคราะห์ข้อมูล ได้แก่ ค่าความถี่ ค่าร้อยละ ค่าเฉลี่ย ค่าส่วนเบี่ยงเบนมาตรฐาน ทดสอบค่าที วิเคราะห์ความแปรปรวนแบบทางเดียว และค่าสถิติสัมประสิทธิ์สหสัมพันธ์	ผลการวิจัยพบว่า 1) ธุรกิจร้านอาหารของผู้ตอบแบบสอบถามส่วนใหญ่ตั้งอยู่ที่เทเวศร์ ดำเนินธุรกิจมาแล้วเป็นระยะเวลา 5-10 ปี โดยเป็นธุรกิจขนาดใหญ่ (มากกว่า 20 โต๊ะ) ที่มีพนักงานจำนวนมากกว่า 15 คน ในขณะที่มียอดขายเดือนละ 300,000 บาทขึ้นไป ทั้งนี้อาหารประเภทแกงเป็นอาหารที่ขายดีที่สุดของร้าน และมีกลุ่มลูกค้าหลักของร้านเป็นทั้งคนไทยและคนต่างชาติ 2) ธุรกิจร้านอาหารให้ความสำคัญต่อปัจจัยที่เกี่ยวข้องต่อการดำเนินธุรกิจ ดังนี้ 2.1) ธุรกิจร้านอาหารให้ความสำคัญต่อปัจจัยภายใน โดยรวม อยู่ในระดับมาก เมื่อพิจารณาเป็นรายด้านเรียงจากมากไปหาน้อย พบว่า ด้านที่มีค่าเฉลี่ยสูงสุดคือ ด้านการตลาด รองลงมาคือ ด้านทำเลที่ตั้ง และน้อยที่สุดคือ ด้านบุคลากร 2.2) ธุรกิจร้านอาหารให้ความสำคัญต่อปัจจัยภายนอกที่เกี่ยวข้องต่อการดำเนินธุรกิจโดยรวม อยู่ในระดับมาก เมื่อพิจารณาเป็นรายด้านเรียงจากมากไปหาน้อย พบว่า ด้านที่มีค่าเฉลี่ยสูงสุดคือ ด้านปัจจัยด้านกฎหมาย รองลงมาคือ ด้านลูกค้า และน้อยที่สุดคือ ด้านคู่แข่ง 3) ธุรกิจร้านอาหารให้ความสำคัญของกลยุทธ์การปรับตัววิถีใหม่เพื่อความอยู่รอดในการดำเนินงาน โดยรวม อยู่ในระดับมาก เมื่อพิจารณาเป็นรายด้านเรียงจากมากไปหาน้อย พบว่า ด้านที่มีค่าเฉลี่ยสูงสุดคือ ด้านผลิตภัณฑ์ รองลงมาคือ ด้านราคา และน้อยที่สุดคือ ด้านกระบวนการ 4) ธุรกิจร้านอาหารที่มีสภาพการดำเนินงานแตกต่างกัน ให้ความสำคัญต่อกลยุทธ์การปรับตัววิถีใหม่เพื่อความอยู่รอดในการดำเนินงานของธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน แตกต่างกันในทุกด้าน และ 5) ปัจจัยภายในและภายนอกของธุรกิจโดยรวม มีความสัมพันธ์กับกลยุทธ์การปรับตัววิถีใหม่เพื่อความอยู่รอดในการดำเนินงานของธุรกิจร้านอาหารไทยในเครือสตีฟ คาเฟ่ แอนด์ ครุยซีน อย่างมีนัยสำคัญทางสถิติที่ระดับ .05