bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of the neutrophil-to-lymphocyte ratio for treatment response in patients diagnosed with definite or probable autoimmune encephalitis/encephalopathy
Authors: Ogami Shuhei , Koh Jinsoo , Miyamoto Katsuichi , Mori Megumi , Takahashi Maiko , Nakayama Yoshiaki , Sakata Mayumi , Hiwatani Yasuhiro , Kajimoto Yoshinori , Ishiguchi Hiroshi , Ito Hidefumi 
Published: October 2023

IntroductionAutoimmune encephalitis/encephalopathy (AE) is a complex and heterogeneous disease, making it difficult to predict the prognosis. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential prognostic tool, but its usefulness remains a matter of debate. This study aimed to explore prognostic factors in cases of clinically definite or probable AE, including those with autoantibody-negative, or unknown status.MethodsData on patients diagnosed with definite or probable AE, including those with autoantibody-negative, or unknown status, were retrospectively collected from the admission records of our department between January 2013 and December 2022. These patients were then categorized into either a good- or poor-response group, based on their short-term treatment response. Clinical characteristics, auxiliary examinations, and treatments were compared between the two groups. A multivariable logistic regression model was constructed to identify independent predictors of poor short-term treatment response by Akaike information criterion backward stepwise method.ResultsA total of 31 patients were included in the final analysis, with 18 of them included in the poor-response group. In the univariable analysis, the poor-response group had a higher proportion of patients with a modified Rankin Scale (mRS) high score upon admission, female, epileptic seizures, or NLRs of 3.93 or higher than the good-response group (all p &lt; 0.10). Furthermore, the multivariable logistic regression analysis revealed that the mRS score upon admission [OR: 5.51, 95% confidence intervals (CI): 1.29–23.50, p = 0.02], epileptic seizures (OR: 10.01, 95% CI: 1.16–86.66, p = 0.04), and NLRs of 3.93 or higher (OR: 11.37, 95% CI: 1.12–114.68, p = 0.04) were significantly associated with poor short-term treatment response.ConclusionThe NLR may play a supplementary role in predicting the short-term treatment response in patients diagnosed with definite or probable AE, including those with autoantibody-negative, or unknown status.
A qualitative study of food sociality in three provinces of South China: social functions of food and dietary behavior
Authors: Yan Youxuan , Petersen Jindong Ding , Lin Liuting , Chen Juncai , Li Xiyi , Ji Guiyuan , Zhang Fan 
Published: October 2023

BackgroundFood sociality refers to the exploration of food production, exchange, distribution, and consumption and influences on cultural communication and social meaning. This study aimed to investigate food sociality in three provinces of South China to provide theoretical and practical evidence of food sociality in the region and to revise nutrition policies.Materials and methodsWe conducted a qualitative study comprising 25 experts in the fields of nutrition, sociology, food science, and agriculture from Hainan, Guangdong, and Guangxi Province by using a semi-structured in-depth interview, which included 28 pre-determined questions covering six topics. The interviews were conducted between November 2020 and March 2021. Verbatim transcripts were analyzed thematically using NVivo 11.0.ResultsOf the 25 experts, the mean age was 50.6 (SD = 8.4) years, 15 (60%) were male, and 22 (88%) held a master's degree or above. The analysis showed that food sociality in three provinces of South China mainly comprises social functions of food and dietary behavior. Regarding social functions of food, the experts expressed that food represents local culture (72%, 18 experts), presents social status and economic power (40%, 10 experts), and is central to special occasions, traditional customs, and etiquette activities (60%, 15 experts). In terms of social functions of dietary behaviors, the majority of experts indicated that food is a social communication tool (72% experts), has geographical characteristics (80% experts), and, to some extent, is used as a proxy for reward or punishment. Furthermore, festivals are one of the core elements of food sociality in the region, although food safety is a major concern. Some dietary behaviors, such as overindulgence in afternoon tea and encouraging drinking, may increase the risk of chronic diseases.ConclusionFood sociality in three provinces of South China is mainly related to the social function of food and dietary behavior. It is a combination of local culture, social status and economic power, traditional customs, rewards and punishments, geographical food preference, and social communication tools. The authors recommend increasing food safety at festivals and promoting healthy eating behaviors in order to improve the overall health of the population in this region.
Impact of integrated preventive and curative health package on nutritional status of children under 2 years of age in the health area of Tama, Tahoua region (Niger)
Authors: Pedrero-Tomé Roberto , Marrodán María Dolores , López-Ejeda Noemí , Escruela Montserrat , Rocaspana Merce , Vargas Antonio , Casademont Cristian , Gutiérrez Rui , Lanusse Candelaria 
Published: October 2023

BackgroundNiger, relevant in light of current political coup, is one of the countries with the worst human development indicators, characterized by high fertility rates and extremely high infant mortality rates. Food insecurity in the region is alarming, leading to high malnutrition rates in children. This study aimed to evaluate an integral preventive-curative health program targeting children aged under 2 years in the health area of Tama, district of Bouza, Tahoua.MethodologyAnthropometric follow-up data of 6,962 children aged under 2 years were included in this study. These children received complete vaccination and malaria chemoprevention, and those older than 6 months received nutritional supplementation with a small quantity of lipid-based nutrient supplements. Fundamental growth indicators (height-for-age, weight-for-height, weight-for-age, and middle-upper arm circumference) and the Composite Index of Anthropometric Failure were calculated at the beginning and end of the program (mean time spent in the program: 14.5 ± 6.6 months) The evolution of these indicators was compared with those of a sample from a vertical vaccination program conducted in the neighboring region of Madarounfa on similar dates.ResultsThe proportion of children without anthropometric failure decreased from 59.5 to 40.2% (p &lt; 0.001), with the categories that included stunting increasing the most. When analyzing the anthropometric indicators according to the months of compliance with the program, there was a slight improvement in the indicators of acute malnutrition, whereas those of chronic malnutrition worsened significantly. However, when compared with the Madarounfa sample, the children in the present study registered a significantly lower worsening in all three indicators: height-age (−0.46 vs. -2.44; p &lt; 0.001), weight-height (+0.31 vs. -0.55; p &lt; 0.001) and weight-age (−0.03 vs. -1.63; p &lt; 0.001) difference.ConclusionThe comprehensive preventive-curative health program slightly slows the worsening of cumulative malnutrition in the early years of life in complex contexts, such as southern Niger.
Characterization of the far-red fluorescent probe MitoView 633 for dynamic mitochondrial membrane potential measurement
Authors: Ernst Patrick , Kim Seulhee , Yang Zengqiao , Liu Xiaoguang Margaret , Zhou Lufang 
Published: October 2023

Introduction: MitoView 633, a far-red fluorescent dye, exhibits the ability to accumulate within mitochondria in a membrane potential-dependent manner, as described by the Nernst equation. This characteristic renders it a promising candidate for bioenergetics studies, particularly as a robust indicator of mitochondrial membrane potential (DYm). Despite its great potential, its utility in live cell imaging has not been well characterized.Methods: This study seeks to characterize the spectral properties of MitoView 633 in live cells and evaluate its mitochondrial staining, resistance to photobleaching, and dynamics during DYm depolarization. The co-staining and imaging of MitoView 633 with other fluorophores such as MitoSOX Red and Fluo-4 AM were also examined in cardiomyocytes using confocal microscopy.Results and Discussion: Spectrum analysis showed that MitoView 633 emission could be detected at 660 ± 50 nm, and exhibited superior thermal stability compared to tetramethylrhodamine methyl ester (TMRM), a commonly used DYm indicator, which emits at 605 ± 25 nm. Confocal imaging unequivocally illustrated MitoView 633’s specific localization within the mitochondrial matrix, corroborated by its colocalization with MitoTracker Green, a well-established mitochondrial marker. Furthermore, our investigation revealed that MitoView 633 exhibited minimal photobleaching at the recommended in vitro concentrations. Additionally, the dynamics of MitoView 633 fluoresce during carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP, a mitochondrial uncoupler)-induced DYm depolarization mirrored that of TMRM. Importantly, MitoView 633 demonstrated compatibility with co-staining alongside MitoSOX Red and Fluo-4 AM, enabling concurrent monitoring of DYm, mitochondrial ROS, and cytosolic Ca2+ in intact cells.Conclusion: These findings collectively underscore MitoView 633 as a superb molecular probe for the singular or combined assessment of DYm and other indicators in live cell imaging applications.
Dauciform roots affect the position of the neighboring plants on the economic spectrum in degraded alpine meadows
Authors: Fan Rong , Huang Yulin , Liu Wanting , Jiang Songlin , Ji Wenli 
Published: October 2023

Background and aimsSpecial root structures that can dissolve insoluble phosphorus locked in soil are supposed to contribute not only to the growing status of themselves but also to the neighbouring plants. However, whether dauciform roots have any effect on the neighbouring plants and how does it respond to meadow degradation had not been studied.MethodsAlpine meadows with different degradation statuses were selected and the functional traits of Carex filispica and the co-occurring species Polygonum viviparum were measured to explore their response to degradation, as well as the response of Polygonum viviparum to the dauciform roots of Carex filispica.ResultsThe results showed that 1) the number of dauciform roots decreased with the intensifying degradation, positively related to available phosphorus in the soil and negatively related to the aboveground phosphorus of Carex filispica. 2) Carex filispica and Polygonum viviparum are similar in specific leaf area and specific root area, yet different in the phosphorus content. The available phosphorus in the soil was negatively related to the aboveground phosphorus of Carex filispica and positively related to that of Polygonum viviparum. 3) When lightly degraded, the proportion of dauciform roots had positive effects on the aboveground resource-acquiring traits of Polygonum viviparum, which were no longer significant at heavy degradation. 4) Polygonum viviparum and Carex filispica without dauciform roots have similar performance: a decrease of belowground carbon with the increasing degradation, and a trend toward resource conservation with the increasing proportion of dauciform roots, which did not exist in Carex filispica with dauciform roots.ConclusionOur study found that dauciform roots had a beneficial effect on the resource acquisition of their neighbouring plants. However, due to the uncontrollable nature of natural habitats, whether this effect is stable and strong enough to be performed in ecological restoration requires further lab-controlled studies.
Finding meaning: a realist-informed perspective on social risk screening and relationships as mechanisms of change
Authors: Bunce Arwen E. , Morrissey Suzanne , Kaufmann Jorge , Krancari Molly , Bowen Megan , Gold Rachel 
Published: October 2023

BackgroundSocial risk screening rates in many US primary care settings remain low. This realist-informed evaluation explored the mechanisms through which a tailored coaching and technical training intervention impacted social risk screening uptake in 26 community clinics across the United States.MethodsEvaluation data sources included the documented content of interactions between the clinics and implementation support team and electronic health record (EHR) data. Following the realist approach, analysis was composed of iterative cycles of developing, testing and refining program theories about how the intervention did—or didn't—work, for whom, under what circumstances. Normalization Process Theory was applied to the realist program theories to enhance the explanatory power and transferability of the results.ResultsAnalysis identified three overarching realist program theories. First, clinic staff perceptions about the role of standardized social risk screening in person-centered care—considered “good” care and highly valued—strongly impacted receptivity to the intervention. Second, the physicality of the intervention materials facilitated collaboration and impacted clinic leaders' perception of the legitimacy of the social risk screening implementation work. Third, positive relationships between the implementation support team members, between the support team and clinic champions, and between clinic champions and staff motivated and inspired clinic staff to engage with the intervention and to tailor workflows to their settings' needs. Study clinics did not always exhibit the social risk screening patterns anticipated by the program theories due to discrepant definitions of success between clinic staff (improved ability to provide contextualized, person-centered care) and the trial (increased rates of EHR-documented social risk screening). Aligning the realist program theories with Normalization Process Theory constructs clarified that the intervention as implemented emphasized preparation over operationalization and appraisal, providing insight into why the intervention did not successfully embed sustained systematic social risk screening in participating clinics.ConclusionThe realist program theories highlighted the effectiveness and importance of intervention components and implementation strategies that support trusting relationships as mechanisms of change. This may be particularly important in social determinants of health work, which requires commitment and humility from health care providers and vulnerability on the part of patients.
Aerobic exercise 3 times per week in adult rats did not influence the progression of periodontal disease
Authors: Souza Thalita Borges , Baptista Rafael Reimann 
Published: October 2023

IntroductionPhysical exercise has proven efficacy in the prevention and treatment of chronic diseases, and its anti-inflammatory effect has been evaluated as a potential preventive factor in the progression of periodontal disease, in addition to improving physiological parameters.MethodsTo test this hypothesis regarding its preventive factor, we evaluated the effects of aerobic training on the progression of periodontal disease in 8-month-old Wistar rats (n = 44). The animals underwent a swimming protocol lasting six weeks, with periodontal disease induced by ligature in the fifth week, totaling fourteen days of ligature placement. Anthropometric parameters were measured for subsequent calculations of BMI and Lee's Index. Interleukin-1β testing was performed to measure serum inflammatory parameters, and alveolar bone loss was measured using images to calculate the area of loss.ResultsThe trained animals showed no significant differences compared to the non-trained animals in terms of anthropometric measures. Regarding the area of bone loss, although there were significant differences between the groups with and without periodontal disease, exercise did not demonstrate an impact on rats with the disease. IL-1β analysis did not detect any measurable values in the samples in either group.DiscussionThese findings indicate that the applied exercise protocol was not sufficient to attenuate the progression of periodontal disease. This study did not find an effective impact of physical exercise on the analyzed parameters; however, the results are important in highlighting that the experimental animal model for inducing periodontal disease is efficient, which may encourage further investigations to determine factors that can attenuate its progression. Similarly, the application or development of new exercise protocols that can benefit and enrich the discussion on its positive effects in this disease is important, as there is already evidence suggesting an effective relationship between exercise and disease progression.
Species Diversity of Lycoperdaceae (Agaricales) in Israel, with Some Insights into the Phylogenetic Structure of the Family
Authors: Krakhmalnyi Maxim , Isikhuemhen Omoanghe S. , Jeppson Mikael , Wasser Solomon P. , Nevo Eviatar 
Published: October 2023

The diversity of Lycoperdaceae in Israel was studied. Molecular phylogenetic relationships within the family, and genus Lycoperdon in particular, were inferred using original ITS rDNA sequences of 58 samples belonging to 25 species from Israel and six other countries, together with 66 sequences stored in the GenBank database. The current molecular phylogenetic study recovered the family Lycoperdaceae as a monophyletic group, which was supported in both maximum likelihood and Bayesian analyses. The clades corresponding to the genera Apioperdon, Bovista, Calvatia, Disciseda, and Lycoperdon were revealed. The taxonomic structure of the named genera was partially resolved. Within the genus Lycoperdon, some species received significant statistical support; however, their relationships, as well as the problem of the genus monophyly, mostly remained questionable. As a result of a thorough literature survey, extensive sample collection, and studies of the material stored in the Herbarium of the Institute of Evolution, University of Haifa (HAI, Israel), fifteen species representing five genera were found in the territory of Israel. Six species, namely Apioperdon pyriforme, Bovista aestivalis, Calvatia candida, Lycoperdon decipiens, L. niveum, and L. perlatum, are new additions to the diversity of Lycoperdaceae in Israel. Detailed macro- and micromorphological descriptions, ecology, geography, and critical notes, together with light microscopy photos and SEM micrographs, are provided. In-depth discussion on some taxonomically challenging species is presented.
HUBUNGAN LIFE STYLE DENGAN KEJADIAN HIPERTENSI PADA DEWASA DI DESA JAGARA KECAMATAN DARMA KABUPATEN KUNINGAN TAHUN 2023
Authors: Moonti Mutia Agustiani , Sutandi Andi , Fitriani Nindia Destiana 
Published: October 2023

Latar Belakang : Prevelensi hipertensi berdasarkan hasil pengukuran pada penduduk umur ≥18 tahun di Indonesia sebesar 34,1% ini mengalami peningkatan dibandingkan dengan prevelensi hipertensi pada tahun 2013 sebesar 25,8%. Diperkirakan 1,28 miliar orang dewasa berusia 30- 79 tahun di seluruh dunia menderita hipertensi. Life style merupakan faktor risiko timbulnya hipertensi pada usia dewasa.Tujuan penelitian ini untuk mengetahui hubungan life style dengan kejadian hipertensi pada Dewasa di Desa Jagara Kecamatan Darma Kabupaten Kuningan. Metode : Penelitian ini menggunakan pendekatan cross sectional dengan populasi seluruh penduduk yang menderita hipertensi di Desa Jagara dengan jumlah 792 orang, dan tehnik sampling menggunakan tehnik purposive sampling berjumlah 266 orang diperoleh melalui perhitungan Slovin. Tehnik pengumpulan data menggunakaan kuesioner dan pemeriksaan tekanan darah. Hasil : Diketahui dari 266 responden yang memiliki Life Style kurang baik 165 orang (62,0%), lebih banyak dengan responden yang memiliki life style baik yaitu 101 orang (38,0%). Hasil uji Bivariat menggunakan uji Chi-Square didapatkan nilai P-Value = 0,000 (< dari α 0,05) artinya memiliki Hubungan Life Style Dengan Kejadian Hipertensi Pada Dewasa di Desa Jagara Kecamatan Darma Kabupaten Kuningan Tahun 2023. Simpulan : Ha diterima berarti ada hubungan antara life style dengan kejadian hipertensi pada dewasa di Desa Jagara. Diharapkan tetap menjaga life style yang baik dengan rutin mengontrol kesehatan seperti rutin cek tekanan darah di pelayanan kesehatan terdekat guna mencegah terjadinya hipertensi dan komplikasi.
GAMBARAN PERILAKU CUCI TANGAN PAKAI SABUN (CTPS) SELAMA MASA COVID-19 DI DESA CILEULEUY KECAMATAN CIGUGUR KABUPATEN KUNINGAN
Authors: Firmansyah Rony Suhada , Krisnawati Euis 
Published: October 2023

Latar belakang : COVID-19 sudah dideklarasikan sebagai Darurat Kesehatan Masyarakat secara Global (Global Public Health Emergency) oleh Organisasi Kesehatan Dunia (WHO) pada 30 Januari 2020. Data terbaru yang diumumkan Gugus Tugas Percepatan Penanganan Covid-19 pada tanggal 30 Juni menunjukkan total kasus positif corona di Indonesia kini mencapai 25.216 pasien dan angka ini terus bertambah setiap harinya. Salah satu cara yang mudah untuk mencegah tertularnya Covid-19 ini adalah dengan mencuci tangan menggunakan sabun. Tujuan dari penelitian ini adalah untuk melihat gambaran perilaku cuci tangan pakai sabun pada masyarakat di desa Cileuleuy.
Metode : Jenis penelitian ini adalah desain deskriptif analitik sederhana dengan populasi masyarakat desa Cileuleuy dan sampel yang berjumlah 100 orang. Teknik sampling yang digunakan adalah Simple Random Sampling, teknik pengumpulan data dengan menggunakan kuesioner. Analisis statistik dengan menggunakan univariat. Hasil : Analisis univariat menunjukkan dari 100 responden yang mencuci tangan setiap waktu hanya 43 orang (43%), 63 responden (63%) mencuci tangan menggunakan sabun dan 37 responden (37%) mencuci tangan menggunakan sabun dan hand sanitizer, dan hanya 39 responden (39%) melakukan cuci tangan dengan sempurna.
Simpulan : Perilaku cuci tangan pakai sabun pada masyarakat masih rendah, masyarakat masih belum terbiasa mencuci seperti sebelum menyentuh hidung, mulut dan mata, setelah menerima paket atau makanan online, setelah bersin atau batuk. Peneliti menyarankan agar masyarakat mematuhi dan melaksanakan anjuran pemerintah untuk menerapkan protokol kesehatan selama masa Covid-19 ini.