bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women’s perspectives on ultrasound as primary imaging modality for focal breast complaints: a qualitative study
Authors: Siebers Carmen C. N. , Appelman Linda , Palm Mette , Rainey Linda , Broeders Mireille J. M. , Mann Ritse M. 
Published: February 2025

Abstract

Objectives
The breast ultrasound trial (BUST) demonstrates a high negative predictive value of ultrasound for women presenting with focal breast complaints, suggesting a potential shift from mammography/digital breast tomosynthesis (DBT) to ultrasound as a primary imaging modality. This BUST side-study explored women’s perspectives on adopting ultrasound as the primary diagnostic tool.

Methods
Twenty-nine female BUST participants (mean age = 48.4, SD = 8.3) with benign findings after diagnostic evaluation participated in one of six focus group interviews 18–24 months post-imaging. Discussions were transcribed and analyzed thematically.

Results
Four overarching themes were identified; personal health situation, organization of breast care, effectiveness of imaging, and professionals’ attitudes and roles. Participants considered their own health history and complaint type (personal health situation) and discussed eligibility for national screening programs and the costs of both exams (organization of breast care). Opinions varied on the effectiveness of imaging, particularly regarding the importance of detecting additional non-symptomatic findings with mammography/DBT that may be missed by ultrasound. Concerns were also raised about implementing research findings without conclusive scientific evidence. Health professionals’ attitudes and roles encompassed the influence of GPs’ and radiologists’ attitudes and the process of image interpretation.

Conclusion
These findings reveal diverse attitudes of women towards ultrasound as a primary modality, warranting caution when transitioning to new clinical standards. Providing comprehensive information about the evidence on the benefits and risks of different imaging modalities is essential, and fostering shared decision-making could enhance acceptance. Offering women the choice of additional imaging, such as mammography/DBT after an initial ultrasound, may balance clinical performance with patient autonomy.

Critical relevance statement
Patients’ perspectives on medical procedures are increasingly significant in modern healthcare. Women’s perceived barriers and facilitators to diagnostic imaging, shaped by numerous factors, offer healthcare professionals insights beyond pure biomedical approaches, fostering shared decision-making within radiology and other clinical contexts.

Key Points

This study explores women’s perspectives on breast ultrasound as a primary imaging modality.

Attitudes towards an ultrasound-first approach are shaped by internal and external considerations.

Considerations are highly informed by emotional responses and lack of knowledge.

Insights into women’s perspectives inform healthcare professionals and foster shared decision-making within radiology.

Graphical Abstract
Infrared spectrum analysis of organic molecules with neural networks using standard reference data sets in combination with real-world data
Authors: Punjabi Dev , Huang Yu-Chieh , Holzhauer Laura , Tremouilhac Pierre , Friederich Pascal , Jung Nicole , Bräse Stefan 
Published: February 2025

Abstract
In this study, we propose a neural network- based approach to analyze IR spectra and detect the presence of functional groups. Our neural network architecture is based on the concept of learning split representations. We demonstrate that our method achieves favorable validation performance using the NIST dataset. Furthermore, by incorporating additional data from the open-access research data repository Chemotion, we show that our model improves the classification performance for nitriles and amides.

Scientific contribution: Our method exclusively uses IR data as input for a neural network, making its performance, unlike other well-performing models, independent of additional data types obtained from analytical measurements. Furthermore, our proposed method leverages a deep learning model that outperforms previous approaches, achieving F1 scores above 0.7 to identify 17 functional groups. By incorporating real-world data from various laboratories, we demonstrate how open-access, specialized research data repositories can serve as yet unexplored, valuable benchmark datasets for future machine learning research.
To accurately predict lymph node metastasis in patients with mass-forming intrahepatic cholangiocarcinoma by using CT radiomics features of tumor habitat subregions
Authors: Chen Pengyu , Yang Zhenwei , Ning Peigang , Yuan Hao , Qi Zuochao , Li Qingshan , Meng Bo , Zhang Xianzhou , Yu Haibo 
Published: February 2025

Abstract

Background
This study aims to introduce the concept of habitat subregions and construct an accurate prediction model by analyzing refined medical images, to predict lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (ICC) before surgery, and to provide personalized support for clinical decision-making.

Methods
Clinical, radiological, and pathological data from ICC patients were retrospectively collected. Using information from the arterial and venous phases of multisequence CT images, tumor habitat subregions were delineated through the K-means clustering algorithm. Radiomic features were extracted and screened, and prediction models based on different subregions were constructed and compared with traditional intratumoral models. Finally, a lymph node metastasis prediction model was established by integrating the features of several subregional models, and its performance was evaluated.

Results
A total of 164 ICC patients were included in this study, 103 of whom underwent lymph node dissection. The patients were divided into LNM- and LNM + groups on the basis of lymph node status, and significant differences in white blood cell indicators were found between the two groups. Survival analysis revealed that patients with positive lymph nodes had significantly worse prognoses. Through cluster analysis, the optimal number of habitat subregions was determined to be 5, and prediction models based on different subregions were constructed. A comparison of the performance of each model revealed that the Habitat1 and Habitat5 models had excellent performance. The optimal model obtained by fusing the features of the Habitat1 and Habitat5 models had AUC values of 0.923 and 0.913 in the training set and validation set, respectively, demonstrating good predictive ability. Calibration curves and decision curve analysis further validated the superiority and clinical application value of the model.

Conclusions
This study successfully constructed an accurate prediction model based on habitat subregions that can effectively predict the lymph node metastasis of ICC patients preoperatively. This model is expected to provide personalized decision support to clinicians and help to optimize treatment plans and improve patient outcomes.
Identification of a dual-function peptide for the detection and haematopoietic potency assessment of type I collagen hydrolysates
Authors: Deng Guiya , Wang Jiajun , Men Cuicui , Cao Keyi , Li Chengming , Zheng Liang , Liu Haibin , Guo Shangwei , Huang Yaqin 
Published: February 2025

Abstract
Type I collagen hydrolysate with haematopoietic activity has shown tremendous potential for application in the functional food fields. The identification of peptide with haematopoietic activity to ensure the efficiency of functional foods remains challenging because of the vast combinatorial potential of short peptides from collagen hydrolysates. In the present study, we identified a novel marker peptide (the I-1 peptide, GAAGLpGPK, p: hydroxyproline) for type I collagen with haematopoietic capabilities via theoretical sequence analysis and computational prediction of activity. The I-1 peptide was shown to increase the survival rate of haematopoietic stem cells following injury induced by 5-fluorouracil (5-FU), increasing the survival rate from 65.40 to 105.28%, thereby exhibiting significant haematopoietic activity. More importantly, the mechanism underlying the haematopoietic activity of the I-1 peptide was analogous to activate the JAK/STAT signalling pathway mediated by granulocyte‒macrophage colony‒stimulating factor. On this basis, a high-precision method for the detection of type I collagen hydrolysates was developed using the I-1 peptide (relative standard deviation = 1.57%). This study not only provides novel perspectives for the exploration of haematopoietic peptides but also offers a new methodology for controlling the bioactivity of collagen-based food products.

Graphical Abstract
Innovative Drug Development Approach to Address the Transition to Low Global Warming Potential Propellant Using Hydrofluoroalkane-152a, for Triple Combination Pressurized Metered-Dose Inhaler Products Targeting Small Airways
Authors: Matturro A. , Zambelli E. , Cuoghi E. , Copelli D. , Usberti F. , Fioni A. , Labadini L. 
Published: February 2025

Abstract
Recent and emerging environmental policies have boosted the investigation of pressurized metered-dose inhalers (pMDI) that have a minimal impact on climate change. There is a current move away from existing hydrofluorocarbon (HFC)-based propellants, specifically the hydrofluoroalkane (HFA)-134a and HFA-227ea based pMDI products that are approved for the treatment of asthma and chronic obstructive pulmonary disease (COPD), towards those that use low global warming potential (LGWP) propellants. Changing the propellant to, for example, the less environmentally-damaging HFA-152a, is a focus for many manufacturers. In this paper, we report an innovative approach to developing new pMDI drug products with a LGWP propellant. Moreover, proof of the hypothesis that products containing the current propellant and those using a LGWP propellant can achieve equivalent performance is reported, by showing comparability of a triple combination pMDI (Trimbow®) formulated using the LGWP HFA-152a propellant compared with HFA-134a. This paper will present the use of in silico mathematical modelling, leveraging on Chiesi proprietary Modulite® principles to predict and validate in vitro performances of the drug product under development. Validation is carried out using realistic aerodynamic particle size distribution (rAPSD), a novel approach that offers a more accurate prediction of aerosol distribution by incorporating variations compared to the standard aerodynamic particle size distribution (APSD). Additional in vitro testing validates the prediction of in silico models and confirms good comparability in terms of aerodynamic performance between HFA-152a and HFA-134a, which translates in vivo as evidenced by the preliminary pharmacokinetics (PK) in animal models and the formal clinical PK bioequivalence (BE) studies. (Rony et al. in Pulm Pharmacol Ther 85, 2024).

Graphical Abstract
Pembuatan Katalog Desain Produk Lampu Estetik Sebagai Pemanfaatan Limbah Material Galvalum di PT Sumber Mas Gemilang
Authors: Krisbianto Ari Dwi , Zulaikha Ellya , Rezkita Katon Ageng , Putri Nurul Idzi Lutvi , Kurniawan Arie , Yulardi Audit , Purwanita Nadia Septarina 
Published: February 2025

Material galvalum termasuk dalam kategori material paling laris di pasar Indonesia karena karakteristiknya yang kuat dan ringan. Pada kesempatan kali ini, PT Sumber Mas Gemilang yang merupakan industri produksi galvalum dengan Cold Roll Forming, bersedia menjadi sasaran pengabdian masyarakat dalam menghasilkan guideline atau panduan berupa katalog hasil eksplorasi material limbah galvalum menjadi produk lampu estetik. Material limbah galvalum ini dipilih karena produk sisa produksi yang selanjutnya menjadi limbah industri menjadi suatu masalah serius bagi PT Sumber Mas Gemilang. Walaupun menjadi limbah industri, kondisi limbah galvalum masih layak guna karena bersifat kuat, tahan lama, mudah dibentuk, serta masih memungkinkannya eksplorasi menjadi produk tiga dimensi yang memiliki nilai fungsi dan estetika. Produk lampu estetika dipilih karena merupakan produk yang memiliki demand value tinggi pada masyarakat serta kesesuaiannya dengan karakteristik limbah galvalum dalam hal proses pembentukan dan produksi. Tujuan dibuatnya katalog yang merupakan panduan pembuatan produk dari material limbah industri galvalum bagi PT Sumber Mas Gemilang ini adalah agar ke depannya ITS bersama PT Sumber Mas Gemilang dapat terjun pada masyarakat serta melakukan pemberdayaan masyarakat berdasarkan hasil dari katalog panduan tersebut untuk ikut berperan pada lingkup sustainability dan ekonomi sirkular.
Temporary bilateral uterine artery occlusion in the control of hemorrhage: A case report and review of literature
Authors: Song Yu-Liang , Wang Chun-Feng 
Published: February 2025

BACKGROUND
Intramural pregnancy is rare, with an unclear etiology and pathophysiology. Surgical, medical, and expectant management options are available for this condition. However, most reported cases are managed surgically. Despite the risks of massive intraoperative bleeding and acute and long-term complications, uterine artery embolization is often selected. Temporary occlusion of the bilateral uterine arteries during surgery is associated with fewer complications.
CASE SUMMARY
We reported the case of a patient who was diagnosed with intramural pregnancy approximately one month after medical abortion. We performed laparoscopic resection with hysteroscopy. Since the lesion had abundant blood flow, we temporarily blocked the bilateral uterine arteries to prevent massive intraoperative bleeding. The surgical process went smoothly. The postoperative course was uneventful.
CONCLUSION
Temporary occlusion of the bilateral uterine arteries in the treatment of intramural pregnancy may prevent excessive uterine bleeding during surgery.
Primary mucosa associated lymphoid tissue lymphoma of the gallbladder: A case report and review of literature
Authors: Lee Mi-Rin , Jang Kyu-Yun , Yang Jae-Do 
Published: February 2025

BACKGROUND
The primary lymphomas of mucosa associated lymphoid tissue (MALT) of the gallbladder (GB) is an extremely rare of non-Hodgkin lymphoma. Many patients exhibit symptoms like gallstone disease, and in some cases, the lymphoma may be detected through imaging even without apparent symptoms. Only 19 cases of primary MALT lymphoma in the GB have been previously reported. Differential diagnosis from typical GB carcinoma based solely on imaging findings can be challenging, and definitive diagnosis often requires surgical intervention.
CASE SUMMARY
We present a patient in an 82-year-old man who was initially diagnosed with prostate cancer but incidentally detected GB wall thickening from magnetic resonance imaging conducted for prostatic surgery and subsequent radical cholecystectomy revealed primary MALT lymphoma of the GB. The patient was followed up by a medical oncologist, and after discussion, the decision was made to continue observation with close monitoring without systemic chemotherapy given the asymptomatic presentation
The patient has been free of recurrence for 16 months after the surgery. Although precise diagnosis before the surgery was difficult in this case, preoperative examinations revealed a submucosal tumor-like lesion.
CONCLUSION
MALT lymphoma of GB remains little known in many previous studies. It is really difficult to preoperatively diagnose. The combination of clinical presentation, postoperative histology and immunohistochemistry contribute to diagnosis and carry out appropriate management.
Wood Technological Properties of the Tree of Heaven (Ailanthus altissima (Mill.) Swingle) and Studies on Possible Applications
Authors: Huber Christian , Teischinger Alfred , Stingl Robert , Pramreiter Maximilian , Stadlmann Alexander , Brandner Reinhard , Müller Ulrich 
Published: February 2025

Abstract
The tree of heaven (Ailanthus altissima (Mill.) Swingle) is a neophyte that is classified as highly invasive. This study shows that in contrast to the challenges the forestry industry faces with this species, the wood of the tree of heaven has considerable promising technological and pulp and paper properties. The attractive wood is hardly distinguishable from European ash (Fraxinus excelsior L.) both visually and in its mechanical properties. Consequently, the wood of the tree of heaven also has a high potential for load-bearing and solid-wood applications. A final technological evaluation of the wood is challenging because the tree of heaven is currently being massively combated, which negatively affects the quality of the roundwood material. Therefore, noncontrolled free-standing trees were examined in this study.
Educar l'inconscient infantil: una proposta per l'Escola Primària
Authors: Valls Morató Joaquim 
Published: February 2025

Educar l’inconscient infantil és possible i recomanable per tal de millorar el caràcter i la intel·ligència vital dels nens d’entre 6 i 12 anys. Es proposa una metodologia que empra tres eines, que no suposen en cap cas un increment del pressupost econòmic de les escoles, ni tampoc una inversió extra de temps per part dels mestres, atès que d’habitud ja s’empren a l’ensenyament primari: l’aprenentatge de la cal·ligrafia, els contes infantils i les cançons ad hoc. Es pretén adaptar per a l’Escola Primària la Programació Neuro-Cal·ligràfica (PNC), per a la reeducació de l’inconscient cognitiu i emocional de persones adultes, amb resultats estadísticament significatius en el Test VIA de les 24 Fortaleses de Caràcter, que dos dels representants més emblemàtics de la psicologia positiva, Martin Seligman i Cris Petersen, van crear l’any 2004 (1). L’enfocament es basa en el supòsit que el cervell i la intel·ligència dirigeixen el capteniment per resoldre problemes que afecten la supervivència i el benestar. En aquest article s’adopta la noció de personalitat a tres nivells (2): temperament (heretat genèticament), caràcter (après mitjançant l'experiència i l’educació) i personalitat escollida (entrenada per viure intel·ligentment). A banda de centrar-se en l'educació del caràcter conscient, que només representa el 5% de la nostra capacitat de pensament, el mètode «3C» pretén, de més a més i, sobre tot, educar l'inconscient neurològic dels nens, mitjançant l'automatització d'hàbits positius. Els ganglis basals, que faciliten la motricitat fina i la integració de pensaments i emocions, són crucials en aquest procés. També es tenen en compte l'hipocamp i el tàlem per tal de, respectivament, reescriure els guions de la biografia en aquells aspectes que impliquen creences limitadores, i redirigir l’atenció executiva en aquells casos que estigui esbiaixada envers una visió negativa disfuncional.
Exposure to arsenic and cognitive impairment in children: A systematic review
Authors: Tian Yumei , Hou Qi , Zhang Mingyue , Gao Er , Wu Yue 
Published: February 2025

Objective
Arsenic exposure is a significant public health concern, particularly for its impact on children’s cognitive development. Arsenic, a prevalent environmental toxin, is known to disrupt various biological pathways, leading to cognitive deficits and neurodevelopmental issues. Understanding the long-term effects and mechanisms underlying arsenic-induced cognitive impairments is crucial for devising effective interventions.

Methods
This systematic review included observational and experimental studies focusing on children under 18 years exposed to arsenic through drinking water, food, or other environmental sources. Studies were selected through comprehensive database searches, encompassing articles that measured cognitive outcomes via standardized tests. The synthesis was primarily narrative, given the heterogeneity in study designs, exposure levels, and outcomes.

Results
The review analysed findings from 24 studies, showing a consistent inverse relationship between arsenic exposure and cognitive performance in children. Higher arsenic levels were associated with lower IQ scores, slower processing speeds, and impaired memory and language skills. These cognitive deficits were evident across diverse geographical regions and persisted even after adjusting for sociodemographic factors. The studies highlighted the potential for both immediate and long-term cognitive effects, underscoring the importance of early-life exposure.

Conclusions
Arsenic exposure has the potential to impair cognitive development in children. Nonetheless, quantitative meta-analysis is necessary to deduce any conclusions related to its impact. Public health efforts must prioritize reducing arsenic exposure through improved water quality and community-awareness programs. Future research should focus on longitudinal studies to better understand the dose-response relationship and the effectiveness of intervention strategies.

Systematic review registration
Prospero, CRD42024544442.
Material Texts: Religion, Mobility, and Responsibility
Authors: Cecil Elizabeth A. , Hazard Sonia 
Published: February 2025

This special issue of Textual Cultures features the work of seven scholars of religion working on material texts across regions, periods, and religious traditions. Mostly focusing on contexts in the global South, the authors challenge Eurocentric narratives about the production, circulation, and reception of texts. Centered on the keywords mobility and responsibility, they suggest the ongoing relevance of paradigms that emphasize textual mobilities and contribute to conversations about scholarly responsibilities to our objects of study.
Pūrṇavarman’s Prints
Authors: Cecil Elizabeth A. 
Published: February 2025

In early West Java (ca. fifth–sixth century CE), the ruler Pūrṇavarman sponsored the creation of a group of inscriptions to praise his virtues and achievements. Engraved on prominent natural rock surfaces at river confluences and high places throughout the polity called Tārumānagara, these innovative works juxtapose poetic texts in Sanskrit with calligraphic designs and carved images of human and animal footprints. The rock inscriptions served a specific set of functions related to Pūrṇavarman’s kingship and his identity as an īśvara — a divine lord able to control and shape the natural environment through acts of thaumaturgy. Pūrṇavarman’s records also bear witness to formative political and religious events in the premodern archipelago. As the earliest surviving examples of writing in the region, they are critical evidence of the harnessing of a new power technology in the service of political spectacle. Previous studies have presented the poetic elements not only in isolation from the accompanying images and signatures, but also from their environmental settings. Through a new contextual analysis, this article examines the design and siting of these multimedia works within the Indigenous environments that made them efficacious.