bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interprofessional collaboration between police and crisis response team in managing
suicide-related cases in Singapore
Authors: Chan V. , Ng K. , Shariffuddin U. K. , Tang X. 
Published: January 2024

Introduction
The Crisis Response Team (CRT) is an interprofessional collaboration between the
Singapore Police Force (SPF) and the Mental Health Helpline (MHH) of the Institute of Mental
Health (IMH). Supported by a multidisciplinary team comprising of the SPF, IMH psychiatrists,
community psychiatric nurses and crisis counsellors, and community partners, this
intervention aims to support suicidal individuals, depending on their risk severity, residing
in the community.

Objectives
To present the CRT work process and to explore the characteristics and outcomes of
suicide-related cases referred.

Methods
In this descriptive research study, a quantitative approach is adopted. An Excel file
shared across the helpline counsellors is used to collate information of the referred cases.
Data collected from October 2021 to August 2022 were evaluated using the IBM SPSS Statistics
for Windows v28.0. Descriptive statistics were used to summarise the characteristics and
outcomes of the cases.

Results
Figure 1 shows the CRT work process. To standardise the method of assessing both
suicide ideation and behaviour, the Columbia-Suicide Severity Rating Scale (C-SSRS) is
utilised. As compared to other suicide ideation and behaviour scales, the C-SSRS has
demonstrated good convergent and divergent validity, high sensitivity and specificity for
suicidal classifications, and moderate to strong internal consistency (Cronbach’s α: 0.73 -
0.95) (Posner et al. AJP 2011; 168(12) 1266-1277). A total of 3,386 suicide-related cases was
referred. The age range of the suicide-related cases range from 8 – 97 years old (M = 36, SD
= 17.33). Of these 3,386 cases, 627 cases were discharged back to their family
members/employer/friend/partner and with follow-up check-in calls by the MHH counsellors, 416
cases were sent to the restructured hospitals for organic workup, 2,268 cases were brought
back to IMH, 55 cases were discharged back to the SPF for further investigation, and 20 cases
warranted CRT home visit activations. Figure 2 shows the total number of referred cases and
outcome of these cases in each month.
Image:

Image 2:

Conclusions
The CRT intervention could mitigate suicide risk and pressure on the mental health
system (i.e., reduce unnecessary emergency room visits and hospital admissions), create
greater mental health awareness, and facilitate individuals’ connection to mental healthcare
services (i.e., in hospitals and/or in the community) as evidenced by the increasing number
of cases referred, and increased collaboration with the various stakeholders, ensuring timely
intervention and necessary follow-ups thereafter.

Disclosure of Interest
None Declared
Comparative Efficacy of First and Second Generation long-acting injectable antipsychotic
upon schizophrenic patients: a systematic review and network metaanalysis.
Authors: Medrano R. , Saucedo E. , Mancias C. , Saucedo C. 
Published: January 2024

Introduction
Long-acting injectable antipsychotics (LAIAs) are currently the most effective
alternative for patients with schizophrenia who exhibit poor adherence. LAIAs can lead the
course of treatment with the potential to increase adherence in schizophrenia
treatment.

Objectives
Present the results of a network metaanalysis on the comparative efficacy of LAIs in
schizophrenia.

Methods
Included trials of adults with schizophrenia compared the efficacy of LAI vs LAI or
placebo through the Positive and Negative Syndrome Scale (PANSS). Efficacy was evaluated
through the standarized mean differences (SMD) from baseline to endpoint in the PANSS total
scores.

Results
Results from 15 studies reported usable results for PANSS score (five antipsychotics
compared) are shown in Figure 1. In hierarchical order, haloperidol, aripiprazole,
risperidone, and paliperidone reduced the PANSS score significantly more than other
drugs.
Image:

Conclusions
Most LAIAs are equally efficient at reducing overall symptoms, and differences between
individual LAIAs are non-significant.

Disclosure of Interest
None Declared
Claudin-5, occludin, zonulin and tricellulin levels of children with attention
deficit/hyperactivity disorder
Authors: Ferahkaya H. , Akca O. F. , Kılınç I. , Baysal T. 
Published: January 2024

Introduction
Accumulating studies have pointed out that gut-blood and blood-brain barrier
dysfunctions due to the alterations in permeability may play a role in the pathophysiology of
neurodevelopmental disorders. Tight junctions are crucial components of these barriers and
some peptides including claudin-5, occludin, zonulin and tricellulin are important components
of these structures.

Objectives
This study aimed to investigate the relationship between these molecules and attention
deficit hyperactivity disorder (ADHD) in children and adolescents.

Methods
A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were
included in the study. The severity of ADHD symptoms was assessed through a parent-rated
questionnaire and Conner’s Continuous Performance Test. Serum levels of biochemical variables
were measured using enzyme-linked immunosorbent assay kits.

Results
Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group
compared to the control group. The difference between the groups in terms of serum claudin-5
and tricellulin levels remained significant after controlling for confounding factors such as
age, gender and autistic characteristics. There was no significant difference between the
groups in terms of serum zonulin and occludin levels. (Table 1)
Table 2.

Serum claudin-5, occludin, zonulin and tricellulin levels of ADHD and
controls

ADHD(n=57)
Controls(n=60)
Statistical
Analysis

ANCOVAc

Mean ± SD
Mean ± SD
z/t
p
F
p
ηp2

Claudin-5
*(ng/mL)
2,14 ± 0,71
2,47 ± 0,71
-3,702
P<
0,001a
10,196
0,002
0,083

Occludin*(ng/mL)
3,75 ± 7,17
2,99 ± 2,75
-0,136
p=
0,892a
0,264
0,608
0,002

Zonulin*(ng/mL)
4,82 ± 5,89
5,06 ± 5,53
-0,076
p=
0,939a
0,008
0,930
< 0,001

Tricellülin(ng/mL)
3,04 ± 0,56
3,34 ± 0,71
-2,552
p=
0.012b
6,650
0,011
0,56

Conclusions
These results suggest that claudin-5 and tricellulin may be involved in the
etiopathogenesis of ADHD. Alterations in these peptides may affect the brain by leading a
dysregulation in intestinal or blood-brain barrier permeability that eventually affects the
gut-brain axis. The causal relationship between these peptides and ADHD requires further
investigation.

Disclosure of Interest
None Declared
Transdiagnostic and Disorder-Specific Resting-State Functional Network Alterations in
Alcohol Use Disorder, Schizophrenia, Bipolar Affective Disorder and Obsessive-Compulsive
Disorder
Authors: Khadse P. A. , Holla B. , G V. , John J. P. , Benegal V. 
Published: January 2024

Introduction
The ICD and DSM diagnostic categories do not represent entirely distinct entities
because several cognitive impairments are shared across psychiatric disorders. Such shared
cognitive impairments are hypothesized to be caused by common neurobiological substrates, one
of which is transdiagnostic alterations in functional network connectivity (FNC).

Objectives
To investigate and compare the within-network functional connectivity (WNFC) and
between-network functional connectivity (BNFC) in alcohol use disorder (AUD), schizophrenia
(SCZ), bipolar affective disorder (BPAD), obsessive-compulsive disorder (OCD) and healthy
controls (HC) using resting-state fMRI employing a data-driven exploratory approach.

Methods
The current study was a secondary analysis of data from the ADBS project in India.
After pre-processing of fMRI data, a spatially and temporally constrained group-independent
component analysis in the GIFT toolbox was performed using the NeuroMark templates to
generate 53 independent components (ICs). These components were divided into seven functional
domains including subcortical (SC), auditory (AU), sensorimotor (SM), visual (VI),
cognitive-control (CC), default-mode (DM), and cerebellar (CB). To investigate the FNC
correlations associated with group status (patients or HC) univariate models were applied
which were subjected to corrections for multiple comparisons at an alpha=0.05 significance
level using the FDR.

Results
The overall sample size was 249 [AUD=35, SCZ=44, BPAD=48, OCD=53, and HC=69].
Transdiagnostic WNFC alterations largely involved dysconnectivity in the CC, DM, and SC
domains, resulting in ICs with both increased and decreased WNFC. Transdiagnostic BNFC
alterations were primarily in the form of increased connectivity of the SC domain with
various cortical domains whereas reduced connectivity was noted between AU, VI, SM, and CB
domains. There was AUD-specific hyperconnectivity in the CC domain and SCZ-specific
hyperconnectivity in the DM domain, and dysconnectivity in the SC domain. BPAD-specific
hyperconnectivity was identified in DM and SC domains in addition to increased connectivity
between CB and SM domains and decreased connectivity between CB and SC domains. All results
were significant at p ≤ 0.05; [FDR] q= 0.05.

Conclusions
Our transdiagnostic WNFC alterations corresponded to the central executive network,
default mode network, salience network, and CSTC loop, which provided transdiagnostic
evidence for the triple network model of psychopathology and underlined the relevance of
subcortical dysconnectivity in this model. Furthermore, our BNFC changes showed subcortical
hyperconnectivity with many cortical networks, underscoring its relevance as a potential
target for transdiagnostic therapeutic interventions.

Disclosure of Interest
None Declared
Acute mutism in a young female. A case report of a 20-year-old female who presents a
3-month mutism
Authors: Gonzalez-Mota A. , Gonzalez-Gil A. , Martin-Gomez C. , Benito-Sanchez J. A. , Peso-Navarro I. M. , Fernandez-Alonso L. 
Published: January 2024

Introduction
A 20-year-old female presents with a progressive 3-month mutism, hyporexia (20kg
weight loss), abulia, anhedonia, apathy, social isolation,seeking company of her parents even
at night, bradypsychia, sialorrhea, psychomotor slowdown and hypomimia. She is hospitalized
in the Psychiatric Brief Hospitalization Unit (PBHU).Her parents relate the beginning of this
symptomatology to a breakup and gender violence,which the patient confirms during the
interview by eye/cephalic movements and single words jotted down.

Objectives
The objective of this study is to describe the evolution of the patient during her
hospitalization in the PBHU of Salamanca and to look into the available bibliography about
mutism related to stress and sialorrhea.

Methods
We carried out a follow-up of the hospitalization of the patient and a structured
search in PubMed with the keywords “mutism”,“sialorrhea” and “stress” in the last 10 years in
English,Spanish and French.

Results
Few or no articles where found.Therefore, the articles about mutism and stress were
analyzed, which focused mostly in selective mutism. Regarding fear,the response to cope with
the threat(fight, flight, freeze) is mediated by the autonomic system. The “Polyvagal Theory”
speaks about the vagus nerve participating in emotion regulation (social communication and
mobilization). Dissociation, in this context,has adaptive and defensive purposes and its
threshold can be reduced by repeated stress situations.Long-term alteration of the autonomic
nervous system has been described in selective mutism.This malfunction can be related to an
elevated production of saliva due to the activation of the parasympathetic in the salivary
glands, causing sialorrhea in our patient.
The patient began treatment with sertraline 100mg and risperidone 2mg with the aim of
its antidepressive and major tranquilizer effects, she also began individual and family
psychotherapy, we assured her sleep and intakes and she began to progressively recover her
speech and mobility,identifying a possible trigger for the symptomatology: a physical beating
of gender violence after her breakup.

Conclusions
Dissociation and “freeze” response can be a maladaptative mechanism to fear.The
malfunction of the autonomic nervous system can explain the disconnection,poor gaze,low
facial and body expression and inability to speak.

Disclosure of Interest
None Declared
Integrating Social Needs Screening and Resource Referral Into Standard Ambulatory Oncology Care: A Quality Improvement Project
Authors: Wethington Stephanie L. , Rositch Anne F. , Yu Ruoxi , Bielman Marie , Topel Kristin , Stone Rebecca L. , Ferriss James Stuart , Fader Amanda N. , Beavis Anna L. 
Published: January 2024

PURPOSE We previously implemented paper-based screening for health-related social resource needs (HRSN) in our gynecologic oncology clinic and found that 36% of patients who completed the screening reported HRSN. We identified two primary deficiencies with our process. First, only 52% of patients completed the screening. Second, 37% of patients with needs failed to indicate if they desired resource referral or not. Therefore, we conducted a quality improvement project to integrate screening and referral processes into the electronic medical record (EMR) and routine clinic workflow to achieve at least 90% screening compliance and 90% elicited referral preference. METHODS A multidisciplinary team consisting of physicians, a health outcomes researcher, a computer programmer, project assistants, and the staff of a partner community organization designed and implemented an intervention that screened for HRSN online via the EMR patient platform or in person during visits. The primary outcome was the percentage of eligible patients who completed the HRSN screening (ie, reach). Outcomes were reviewed weekly, and feedback was provided to stakeholders monthly. Iterative changes were incorporated into five successive Plan-Do-Study-Act (PDSA) cycles completed from January 2021 to March 2023. RESULTS Screening compliance increased from the baseline of 52% (paper-based) to 97% in PDSA 4. Completion via the online patient portal increased from 17% in prelaunch to 49% in PDSA 4. Of patients who reported needs, 100% had a documented referral preference. CONCLUSION Compared with paper-based screening, an EMR-integrated HRSN screening and referral system significantly improved reach to patients at a gynecologic oncology clinic. Implementation efforts to expand to other ambulatory clinic settings are in process.
The formation of large aggregates by Brownian growth and the onset of a runaway process
Authors: Schubert B. , Blum J. , Isensee M. , Molinski N. S. , Pöppelwerth A. , von Borstel I. , Schräpler R. , Balapanov D. , Vedernikov A. 
Published: January 2024

Abstract
In an experiment onboard a microgravity sounding rocket, we observed the growth of agglomerates consisting of

silica spheres under well-defined conditions. After an initial short charge-induced growth phase, the charge-neutralized agglomerates grew due to Brownian-motion–induced collisions, first in an orderly fashion and thereafter, due to the temporal increase in particle concentration, in a runaway process. The latter is characterized by the detachment of large oligarch agglomerates. We modeled the growth using a mean-field approximation as well as a Monte Carlo technique.
S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+ entry
Authors: Mohammed Tareg Omer , Lin You-Rong , Akter Lucky , Weissenbruch Kai , Ngo Kien Xuan , Zhang Yanjun , Kodera Noriyuki , Bastmeyer Martin , Miyanari Yusuke , Taoka Azuma , Franz Clemens M. 
Published: January 2024

ABSTRACT
S100A11 is a small Ca2+-activatable protein known to localize along stress fibers (SFs). Analyzing S100A11 localization in HeLa and U2OS cells further revealed S100A11 enrichment at focal adhesions (FAs). Strikingly, S100A11 levels at FAs increased sharply, yet transiently, just before FA disassembly. Elevating intracellular Ca2+ levels with ionomycin stimulated both S100A11 recruitment and subsequent FA disassembly. However, pre-incubation with the non-muscle myosin II (NMII) inhibitor blebbistatin or with an inhibitor of the stretch-activatable Ca2+ channel Piezo1 suppressed S100A11 recruitment, implicating S100A11 in an actomyosin-driven FA recruitment mechanism involving Piezo1-dependent Ca2+ influx. Applying external forces on peripheral FAs likewise recruited S100A11 to FAs even if NMII activity was inhibited, corroborating the mechanosensitive recruitment mechanism of S100A11. However, extracellular Ca2+ and Piezo1 function were indispensable, indicating that NMII contraction forces act upstream of Piezo1-mediated Ca2+ influx, in turn leading to S100A11 activation and FA recruitment. S100A11-knockout cells display enlarged FAs and had delayed FA disassembly during cell membrane retraction, consistent with impaired FA turnover in these cells. Our results thus demonstrate a novel function for S100A11 in promoting actomyosin contractility-driven FA disassembly.
The knowledge of movement experts about stretching effects: Does the science reach practice?
Authors: Warneke Konstantin , Konrad Andreas , Wilke Jan 
Published: January 2024

Objective
Stretching is performed with numerous purposes in multiple settings such as prevention, rehabilitation, fitness training and sports. Its patterns of use substantially depend on the education and beliefs of health care and exercise professionals as they represent the multiplicators recommending and prescribing interventions to clients, patients and athletes. This study investigated movement experts’ knowledge about the scientific evidence on stretching effects.

Design
Survey study.

Participants
A total of 117 exercise and health professionals (physiotherapists, sports scientists, coaches) attending a training convention in Austria (male: n = 44, female: n = 73, 36±11 years) completed a digital survey. With its 22 items, the questionnaire addressed the movement experts’ awareness of the evidence on stretching effects regarding a variety of related topics selected based on the findings of topical systematic reviews.

Results
The majority of the individuals (57–88%) assumed positive effects of stretching on recovery, prevention of muscle injury, range of motion, muscular imbalance and artery elasticity. No or adverse effects were mostly claimed on bone injury prevention, maximal/explosive strength, and delayed-onset muscle soreness. In only 10 of 22 items, participants’ classifications were in accord with the scientific evidence.

Conclusions
The awareness of research findings on stretching effects among exercise and health professionals is alarmingly low. Future studies may hence be geared to improve implementation and science communication.
Substandard and falsified antimicrobials in selected east African countries: A systematic review
Authors: Tegegne Addisu Afrassa , Feissa Anbessa Bekele , Godena Gemmechu Hasen , Tefera Yesuneh , Hassen Hassen Kebede , Ozalp Yildiz , Suleman Sultan 
Published: January 2024

Background
Globally, millions of people have been affected by fraudulent pharmaceutical products, particularly those in developing countries. Although the problem of falsified and substandard drugs is acknowledged, the extent of the issue is ever-changing, has a dynamic nature, and should be quantified and captured in a recent snapshot.

Objective
This systematic review seeks to examine the data that can quantify and provide a current snapshot of the prevalence of SF antimicrobials in selected east Africa countries.

Methods
Scientific studies on antimicrobial quality were searched in PubMed, Embase, Scopus, and Google Scholar from 2017 to February 2023. The search strategy focused on scientific articles published in peer-reviewed scientific journals written in English and the studies exclusively done in any of the selected countries of east Africa. The articles were carefully reviewed by two individuals for inclusion independently, first by title followed by abstract and the full-text retrieval. To minimize bias associated with the methodology used for data collection, the quality of the studies was assessed for quality according to the Medicine Quality Assessment Reporting Guidelines (MEDQUARG). The reporting of this systematic review was done following Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA).

Results
Fifteen studies that estimated the prevalence of poor-quality antimicrobial medicines in selected four east African countries were included. The overall percentage of samples of antimicrobials that failed at least one quality test was 22.6% (151/669) with each class’s prevalence of 17% in antibiotics (73/432), 24% in antimalarial (41/171), and 56% in anthelmintics (37/66). Quality control parameters of API content were the most commonly examined in the included studies, accounting for 14/15 (93%) studies. Fifty (33.1%) of the failing samples failed assay API- content determination, while 26.5% (n = 40) failed the visual inspection and packaging analysis; 19.2% (29) failed dissolution; 14% (n = 21) flawed hardness or friability; 4%(n = 6) failed uniformity, as well as 3.2% (n = 5) failed disintegration test of the quality control parameter.

Conclusion
It was found that this review was general in these selected east African countries and was a catalyst for combating the menace of poor-quality medications that affect millions of lives.
Endoscopic Surveillance of Intestinal Metaplasia of the Esophagogastric Junction: A Decision Modeling Analysis
Authors: Yoon Ji Yoon , Lim Francesca , Shah Shailja C. , Rubenstein Joel H. , Abrams Julian A. , Katzka David , Inadomi John , Kim Michelle Kang , Hur Chin 
Published: January 2024

INTRODUCTION:
The incidence of esophagogastric junction adenocarcinoma (EGJAC) has been rising. Intestinal metaplasia of the esophagogastric junction (EGJIM) is a common finding in gastroesophageal reflux (irregular Z-line) and may represent an early step in the development of EGJAC in the West. Worldwide, EGJIM may represent progression along the Correa cascade triggered by Helicobacter pylori. We sought to evaluate the cost-effectiveness of endoscopic surveillance of EGJIM.

METHODS:
We developed a decision analytic model to compare endoscopic surveillance strategies for 50-year-old patients after diagnosis of non-dysplastic EGJIM: (i) no surveillance (standard of care), (ii) endoscopy every 3 years, (iii) endoscopy every 5 years, or (iv) 1-time endoscopy at 3 years. We modeled 4 progression scenarios to reflect uncertainty: A (0.01% annual cancer incidence), B (0.05%), C (0.12%), and D (0.22%).

RESULTS:
Cost-effectiveness of endoscopic surveillance depended on the progression rate of EGJIM to cancer. At the lowest progression rate (scenario A, 0.01%), no surveillance strategies were cost-effective. In moderate progression scenarios, 1-time surveillance at 3 years was cost-effective, at $30,989 and $16,526 per quality-adjusted life year for scenarios B (0.05%) and C (0.12%), respectively. For scenario D (0.22%), surveillance every 5 years was cost-effective at $77,695 per quality-adjusted life year.

DISCUSSION:
Endoscopic surveillance is costly and can cause harm; however, low-intensity longitudinal surveillance (every 5 years) is cost-effective in populations with higher EGJAC incidence. No surveillance or 1-time endoscopic surveillance of patients with EGJIM was cost-effective in low-incidence populations. Future studies to better understand the natural history of EGJIM, identify risk factors of progression, and inform appropriate surveillance strategies are required.