bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of the neuroprotective efficacy of vitamin K in a streptozocin‐induced diabetes model in chick embryos
Authors: Vurmaz Ayhan , Atay Emre , Rakip Usame , Koca Tülay 
Published: December 2023

AbstractDiabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to insulin deficiency and/or resistance. Vitamin K (VK) is a group of fat‐soluble molecules, including naturally occurring vitamin K1 (phylloquinone). vitamin K2 (menaquinone), and synthetic vitamin K3 (menadione). Beyond coagulation, the health benefits of VK have been described to play different roles in both physiological and pathological processes such as inflammation, energy metabolism, neuroprotection, cellular growth, and survival. It was aimed to observe the antioxidant and/or neuroprotective activity of vitamin K1 in our model of chick embryo diabetic neuropathy (DN) induced by streptozotocin (STZ). Ninety White Leghorn, fertile and 0‐day‐old SPF (specific pathogen‐free) eggs (57 ± 4 gr) were used in the study. Chick embryo blood brain tissues were taken for biochemical evaluation. Plasma insulin and glucose levels were measured. In addition, brain tissue total antioxidant level (TAS), total oxidant level (TOS), malondialdehyde (MDA), and vascular endothelial growth factor (VEGF) levels were measured. Plasma glucose levels were higher in the STZ‐treated groups and lower in the treatment groups. Plasma insulin levels were observed to be higher in STZ groups in groups treated with high VK. Low TAS, high MDA, TOS, and VEGF levels were recorded in brain tissue STZ groups. Low VEGF, TOS, and MDA levels were recorded in the group treated with the highest VK, while high TAS levels were observed. In our STZ‐induced chick embryo diabetic neuropathy model, we observed that VK1 reduced oxidant damage by showing antioxidant properties or by modulating antioxidant enzymes.
SpyGlass DS system‐assisted retrieval of proximally migrated pancreatic duct stent in a patient with chronic pancreatitis
Authors: Thongpiya Jerapas , Lanke Gandhi , Yingchoncharoen Pitchaporn , Das Kanak 
Published: December 2023

AbstractPancreatic duct (PD) stent migration is among the recognized complications of endoscopic retrograde cholangiopancreatography (ERCP) with PD stent placement. Proximal stent migration poses a challenge for removal due to risks of PD damage, smaller caliber, and possible stricture. Here, we present a case of SpyGlass DS system‐assisted PD stent repositioning after failure with traditional tools.
Heroes in oriented complete multipartite graphs
Authors: Aboulker Pierre , Aubian Guillaume , Charbit Pierre 
Published: December 2023

AbstractThe dichromatic number of a digraph is the minimum size of a partition of its vertices into acyclic induced subgraphs. Given a class of digraphs , a digraph is a hero in if ‐free digraphs of have bounded dichromatic number. In a seminal paper, Berger et al. give a simple characterisation of all heroes in tournaments. In this paper, we give a simple proof that heroes in quasitransitive oriented graphs (that are digraphs with no induced directed path on three vertices) are the same as heroes in tournaments. We also prove that it is not the case in the class of oriented multipartite graphs, disproving a conjecture of Aboulker, Charbit and Naserasr, and give a characterisation of heroes in oriented complete multipartite graphs up to the status of a single tournament on six vertices.
Surgical Correction of Nasal Obstruction and Its Effect on Eustachian Tube Dysfunction Symptoms
Authors: Daum Rachel , Grimm David , Castro Silva Bruna R. , Huang Alice E. , Lee Jennifer Y. , Nayak Jayakar V. , Patel Zara M. , Hwang Peter H. , Chang Michael T. 
Published: December 2023

AbstractObjectivesTo investigate how eustachian tube dysfunction symptoms change following surgical treatment of nonsinusitis‐related nasal obstruction.Study DesignRetrospective chart review.SettingSingle academic center.MethodsWe assessed patients who underwent septoplasty, turbinate reduction, or both for nasal obstruction. Chronic sinusitis patients were excluded. Eustachian tube dysfunction (ETD) symptoms were studied using the Eustachian Tube Dysfunction Questionnaire (ETDQ‐7), collected preoperatively and postoperatively (1 week, 1 month, 3 months, 6 months postop). Patients with preoperative ETDQ‐7 > 14.5 were considered to have clinically significant symptoms. Sinonasal outcomes test scores were also assessed. Pre‐ and postoperative ETDQ‐7 scores were compared using t test. Multivariate linear regression analysis identified factors associated with ETDQ‐7 change.ResultsWe analyzed 259 patients. Preoperatively, 37.5% of patients with nasal obstruction had clinically significant ETD symptoms. These patients exhibited significant improvement in ETDQ‐7 at all postoperative timepoints from 23.3 ± 7.6 at baseline to 19.1 ± 9.1 at 1 week, 16.5 ± 8.0 at 1 month, 16.2 ± 7.8 at 3 months, and 16.7 ± 10.4 at 6 months (all P < .01). In patients without baseline ETD symptoms, (baseline ETDQ‐7: 9.1 ± 2.3) ETDQ‐7 scores did not change significantly at postoperative timepoints, except for an acute worsening at 1 week postoperatively (10.7 ± 5.1, P < .001). Regression analysis showed that higher preoperative ETDQ‐7 score (β = −0.84, 95% confidence interval [CI]: −1.10 to −0.59) and postoperative antihistamine spray usage (β = −8.70, 95% CI: −14.20 to −3.20) were associated with ETDQ‐7 improvement, while comorbid GERD (β = 7.50, 95% CI: 3.42‐11.58) and asthma (β = 5.62, 95% CI: 0.80‐10.45) were negatively associated with improvement.ConclusionSurgical correction of nasal obstruction may improve ETD symptoms.
Construction mechanism of gellan gum/chitosan/calcium ion multiple‐network hydrogel by self‐assembly strategy and its regulation
Authors: Liang Lili , Liang Xuan , Lin Xiaoyan , Zhang Hao , Pang Chunxia , Pan Xunhai , Hu Yang , Chen Yan , Luo Xuegang 
Published: December 2023

AbstractRecently, double‐network or multiple‐network hydrogel constructed by physical methods has been considered a green method to improve the comprehensive properties of biomass hydrogel. Herein, a novel physically cross‐linked hydrogel with multiple network of gellan gum/chitosan/calcium ion (GG–CS–Ca) was constructed by self‐assembly to accomplish the synergistic improvement of mechanical strength and uranium adsorption property compared to adsorbents GG–Ca and carboxymethyl konjac glucomannan/GG–Al originated from gellan gum previously prepared. Moreover, the driving mechanism of self‐assembly of GG–CS–Ca was deduced by 13C solid state nuclear magnetic resonance spectroscopy (13C‐SSNMR), rheological analysis, and phase transition analysis. The results indicated electrostatic interaction was dominant during the self‐assembly of GG–CS–Ca. The self‐assembly mechanism was also illustrated by investigating the x‐ray photoelectron spectrometer (XPS) combined with the analysis of the phase transition process. Comprehensively, the self‐assembly constructed GG–CS–Ca hydrogel network contained three kinds of network including the GG–CS network constructed by electrostatic action of protonated CS with negative charged GG, the GG–Ca network constructed by ionic cross‐linking of COO− in GG and Ca2+, and the GG network formed after the phase transformation of GG hot sol by cooling. It explored a new method for constructing biomass‐based physical hydrogels with both favorable mechanical strength and uranium adsorption capacity in uranium removal.Highlights
A novel physically cross‐linked hydrogel (GG–CS–Ca) with multiple network was constructed by self‐assembly.
The GG–CS–Ca hydrogel accomplished the synergistic improvement of mechanical strength and uranium adsorption properties.
The self‐assembly mechanism of constructing the GG–CS–Ca hydrogel network contained three aspects.
The electrostatic interaction was the dominant action during the self‐assembly of GG–CS–Ca.
Eco‐friendly production and performance evaluation of water‐resistant cellulose nanofiber bioaerogels
Authors: Mawardi Indra , Saharudin Nur Izzaati , Ahmad Azfaralariff , Khalil H. P. S. Abdul , Abdullah Che Ku , Yahya Esam Bashir 
Published: December 2023

AbstractA sustainable and environmentally conscious approach was employed to create a cellulose nanofiber (CNF) bioaerogel. This modified technique was used for its affordability and eco‐friendly nature, involved the use of reduced concentrations of NaOH solution (ranging from 0 to 0.5 M) to disperse the CNFs. The process included mixing, freezing, neutralizing, and freeze‐drying, ultimately resulting in well‐structured 3D bioaerogels. The concentration of NaOH had a significant impact on the properties of the bioaerogels. The density of the aerogels increases with higher concentration of NaOH. All treated aerogels exhibited impressive water resistance and maintained their structural integrity when exposed to water, indicating promising practical applications. This enhanced structural integrity is attributed to CNF chain rearrangement, facilitated by CNF swelling, dissolution in NaOH, and homogenization. FTIR and XRD analyses provided insight into the transition from cellulose I to cellulose‐II in the bioaerogel structure. These findings contribute to the development of eco‐friendly bioaerogels for environmentally conscious applications. Further research is needed to gain a deeper understanding of the process and to optimize conditions for specific bioaerogel properties.
The quantum revolution in vehicle sensor technology
Authors: Pang Hao 
Published: December 2023

AbstractWith technology like lidar heralding a revolution in vehicle automation, SWIR (short‐wave infrared) imaging and sensing will become increasingly vital to the automotive sector. Quantum dots, nanoscale semiconductors tunable to SWIR wavelengths, could provide the answer to empowering SWIR and bringing enhanced capability to the mass market.
Breastfeeding in infants who aspirate may increase risk of pulmonary inflammation
Authors: Duncan Daniel R. , Golden Clare , Larson Kara , Williams Nina , Simoneau Tregony , Rosen Rachel L. 
Published: December 2023

AbstractObjectiveTo evaluate management strategies and pulmonary outcomes for breastfed infants with oropharyngeal dysphagia.Study DesignWe performed a retrospective cohort study of breastfed infants diagnosed with oropharyngeal dysphagia with documented aspiration or laryngeal penetration on videofluoroscopic swallow study (VFSS). Medical records were reviewed for VFSS results and speech‐language pathologist recommendations following VFSS, results of chest x‐ray, results of bronchoalveolar lavage (BAL) within 1 year of VFSS, and aspiration‐related hospitalizations occurring before or within 1 year of VFSS. Subjects were categorized as cleared or not cleared to breastfeed based on the VFSS. Proportions were compared with Chi‐square and Fisher's exact tests and means with Student's t‐tests.ResultsSeventy‐six infants (4.7 ± 0.4 months old) were included; 50% (38) had aspiration and 50% (38) had laryngeal penetration. After VFSS, 70% (53) were cleared to breastfeed while 30% (23) were not cleared to breastfeed. Patients with aspiration were less likely to be cleared to breastfeed (p = .006); however, 55% (21/38) of those with aspiration were still cleared to breastfeed. Infants cleared to breastfeed had significantly more pulmonary hospitalizations (p = .04) and were also at increased risk of elevated neutrophil count (p = .02) and culture growth on BAL (p = .01). Significantly increased abnormal neutrophil count was also found in those cleared to breastfeed with laryngeal penetration (p = .01).ConclusionsInfants with oropharyngeal dysphagia counseled to continue breastfeeding had increased risk of BAL inflammation and more pulmonary hospitalizations compared to those that were told to stop breastfeeding.
Dual‐Energy CT in Breast Cancer: Current Applications and Future Outlooks
Authors: Guo Shaolan , Liu Tianye , Qu Guobin , Xu Jian , Liu Qingzeng , Zhao Qian , Bi Zhao , Li Wanhu , Zhu Jian 
Published: December 2023

AbstractBreast cancer is the most prevalent cancerous tumor in women, characterized by different subtypes and varying responses to treatment. The continued evolution of breast cancer diagnosis and management has resulted in a transition from a one‐size‐fits‐all approach to a new era of personalized treatment plans. Therefore, it is essential to accurately identify the biological characteristics of breast tissue in order to minimize unnecessary biopsies of benign lesions and improve the overall clinical process, leading to reduced expenses and complications associated with invasive biopsy procedures. Challenges for future research include finding ways to predict the response of breast cancer patients to adjuvant systemic treatment.Dual‐energy CT (DECT) is a new imaging technology integrating functional imaging and molecular imaging. Over the past decade, DECT has gained relevancy, especially in oncological radiology. This article proposed a literature review of the application and research status of DECT in breast cancer treatment strategy determination and prognosis prediction.
Se as Eutectic Accelerator SPAN Cathode for K−S Batteries with Improved Specific Capacity and Reaction Kinetics
Authors: Yang Fang , Yun Zimeng , Gao Huihui , Gao Shuhan , Tian Zhihong , Huang Jiajia 
Published: December 2023

AbstractPotassium‐sulfur (K−S) batteries are regarded as the most promising energy storage applications due to its excellent specific capacity, widespread resources and low‐cost of potassium and sulfur. As a cathode material, the unique solid‐solid reaction mechanism of sulfurized poly(acrylonitrile) (SPAN) effectively restrains the shuttle effect and closes to 100 % for coulombic efficiency. However, the application of SPAN is still limited by its sluggish kinetics and inferior cycle performance. Herein, a SPAN with Se as eutectic accelerator (Se‐SPAN) was synthesized via vacuum melting and sulfurization treatments, Se not only enhances the reaction kinetics of S but also improves utilization rate of S. Compared to SPAN, the Se‐SPAN shows outstanding capacity of 1551 mAh g−1 at 0.1 C and 1311.3 mAh g−1 at 0.5 C. In addition, a superior cycle stability is acquired with a capacity retention of 87.4 % at 0.5 C for 100 cycles. Therefore, this work provides a strategy to design high performance electrode materials for K−S batteries.
Construction of Low Cost, and Platinum‐Free Counter Electrode for Dye‐Sensitized Solar Cells
Authors: Ahmad Khursheed , Niyitanga Theophile , Quasim Khan Mohd , Ahmad Khan Rais , Kim Haekyoung 
Published: December 2023

AbstractRecently, design and fabrication of platinum free counter electrodes have received enormous attention of the scientific community. In this work, we have fabricated manganese dioxide/reduced graphene oxide (MnO2@Gr) counter electrode based DSSCs. Hydrothermal method was utilized for the synthesis of MnO2@Gr. Further, X‐ray diffraction technique (XRD), scanning electron microscopy (SEM), and energy dispersive X‐ray spectroscopy (XPS) were employed as physiochemical characterization technique. Surface structural investigations showed that MnO2 has rods like surface morphology which are attached with Gr. The fabricated DSSCs demonstrated good open circuit voltage (Voc) and reasonable efficiency of 0.72 V and 5.87 %, respectively.
An ′On‐off‐on′ Fluorescence Sensor Based on CdSe Quantum Dots for the Selective Detection of Cd2+
Authors: Wu Huiyan , Liang Zhaowei , Zhang Zihan , Jiang Naijia , Luo Jianhua , Yang Liyun , Zhou Zhiqiang 
Published: December 2023

AbstractIn this work, an “on‐off‐on” nanoprobe for specific detection of Cd2+ was constructed using N‐acetyl‐l‐cysteine (NAC)‐modified CdSe quantum dots (QDs). The prepared CdSe QDs exhibit characteristic green fluorescence. The adsorbed S2− on the surface of CdSe QDs leads to dangling bonds and causes the fluorescence quenching of QDs, where the fluorescence of the system turns “off“. When Cd2+ exists, it can react with the adsorbed S2− to form CdS shell, resulting in the fluorescence enhancement of CdSe QDs, where the fluorescence of the system turns “on”. Due to the similar lattice structure between CdSe and CdS, CdSe/CdS can be produced by shell deposition, while self‐nucleation of metal sulfide is observed in the presence of other metal ions. Thus, the developed nanoprobe shows high selectivity for Cd2+. Under the optimum sensing conditions, the fluorescence sensing signal of CdSe QDs depends linearly on the Cd2+ in the range of 0.2–9 μM. The limit of detection (LOD) and limit of quantification (LOQ) of this nanoprobe is 27 nM and 90 nM, respectively. Furthermore, the proposed nanoprobe can monitor Cd2+ in drinking water with a recovery rate between 95.82 % and 102.00 %, indicating its good practicability and applicability for real sample analysis.
Synthesis, Docking and In Vitro Evaluation of Spiroindoline‐3,2’‐Quinazoline Derivatives
Authors: Addu Narender , Miriyala Hinuja , Kapavarapu Ravikumar , Kolli Sunder Kumar , Pal Manojit 
Published: December 2023

AbstractThe Wang‐OSO3H catalyzed synthesis of a series of spiroindoline‐3,2’‐quinazoline derivatives and their in silico and in vitro evaluation against MtbCM (Mycobacterium tuberculosis Chorismate Mutase) are disclosed. Initially, a library of small molecules based on spiroindoline‐3,2’‐quinazoline framework was constructed. The reaction of 2‐aminobenzamide with appropriate isatin derivatives in the presence of Wang‐OSO3H under ultrasound irradiation was used for this purpose. The reaction proceeded under mild conditions to afford the desired products in good yields within a short duration. With the use of heterogeneous catalyst, inexpensive solvent as reaction media, and ultrasound as the source of green energy the methodology appeared to be a useful alternative to the previously reported methods. The in silico docking of all the synthesized compounds into the MtbCM (PDB: 2FP2) revealed that the binding of these compounds took place on the external surface pockets of the MtbCM active site cavity mainly in two different clusters. Three compounds that interacted well with MtbCM also showed good (57–64 %) inhibition of MtbCM in vitro when tested at 10 μM. Based on in silico and in vitro studies along with the ADME predictions these three spiroindoline‐3,2’‐quinazoline derivatives were identified as pre‐hits.
Synthesis, Characterization, and Biological Activity of Di‐2‐pyridyl Ketone Aryl Hydrazone and Its Copper(II) Complex and the Interaction of Di‐2‐pyridyl Ketone Aryl Hydrazone with DNA Bases
Authors: Çınarlı Murat , Kıray Esin , Ataol Çiğdem Yüksektepe 
Published: December 2023

AbstractThe development of antibiotic resistance has also increased the interest in hydrazones. In this paper, we describe the new aroyl hydrazone and its Cu(II) complex, which we synthesized. Aroyl hydrazone (HL) was prepared by the condensation reaction of 3‐hydroxy‐2‐naphthoic hydrazide with di‐2‐pyridyl ketone. Ligand (HL) and its transition metal complexes [CuL2] (1), have been characterized by elemental analysis, FT‐IR, UV‐Vis., 1H‐NMR, and LC–MS techniques. The molecular structure of HL, whose crystal structure could not be obtained, was elucidated by the DFT/B3LYP/6‐311+G(d, p) method. The optimized molecular structure, total energy, molecular orbital energy values, molecular electrostatic potential map, reactivity parameters, and interaction with DNA bases were investigated. Theoretical UV‐vis spectra of HL were obtained with TD‐DFT in different solvent environments. In addition, the ligand and its complex were examined for their antimicrobial activity against pathogenic microorganisms by using a minimal inhibitory concentration method (MIC). It was determined that the [CuL2] (1) complex was generally moderately active. It was also observed that the [CuL2] (1) complex was more active than the HL.
Design, Synthesis, and Bioactivity Assessment of Novel 2‐Phenyl Indole Derivatives Incorporating 4‐Thiazolidinone‐5‐carboxylic Acid as Promising Anti‐cancer Agents
Authors: Tongkhan Sukanya , Radchatawedchakoon Widchaya , Kruanetr Senee , Sakee Uthai 
Published: December 2023

AbstractWe conducted a study to create new chemical compounds using indole derivatives, specifically incorporating thiosemicarbazone (8 a–e) and 4‐thiozolidinone‐5‐carboxylic acid (9 a–e) structures. We then tested these compounds against various bacteria and cancer cells. In our antibacterial tests, the compounds showed moderate inhibitory effects on bacterial growth. However, when we examined their effects on cancer cells, we observed specific patterns of activity. Notably, compounds 9 c and 9 d were highly toxic to NCI‐H187 cancer cells, while compounds 8 c, 9 b, 9 c, 9 d, and 9 e exhibited moderate inhibitory activity against KB cancer cells. Compound 8 e displayed strong toxicity against MCF‐7 cancer cells. When we assessed the toxicity of these compounds on normal Vero cells, we found that compounds 8 e, 9 b, 9 c, 9 d, and 9 e were less toxic compared to ellipticine, a known anticancer drug. These results suggest that these newly synthesized compounds may have potential applications in cancer treatment, and further research is necessary to explore their therapeutic possibilities.
From Propylene to 4‐Methyl‐1‐pentene over K‐Cu Supported Catalytically Active Liquid Metal Solutions
Authors: Chen Ping , Ling Yu , Tong Hongkai , Dong Ke , Liu Xu , Chen Xiao , Liang Changhai 
Published: December 2023

AbstractThe urgent need for branched‐chain α‐olefin (4‐methyl‐1‐pentene) with excellent characteristics promotes the development of efficient catalysts for the selective dimerization of propylene to it. Based on the concept of supported catalytically active liquid metal solutions (SCALMS), the highly efficient K−M/K2CO3 (M=Fe, Co, Ni, Cu, and Zn) catalysts are prepared by the melting method for the dimerization of propylene. The K−Cu SCALMS catalyst presents highly efficient and excellent selective C−C linkage, as well as limits the isomerization of C6 products. The highest conversion of propylene (64.3 %) with 80.6 % selectivity to 4‐methyl‐1‐pentene with thermodynamic instability is reached at 160 °C, 6 MPa and 20 h. Furthermore, the post‐reaction K−Cu SCALMS catalyst can be successfully reactivated in the H2 atmosphere. Therefore, it is proposed that it may be achieved the continuous selective dimerization of propylene to 4‐methyl‐1‐pentene over K−Cu SCALMS catalyst by the application of fluidized bed technology.
Silver Catalyzed Cascade Strategy for the Synthesis of Diversely Substituted Polycyclic Fused 1,7‐Naphthyridine Scaffolds
Authors: Chahal Kapil , Vani Damera , Pranay Kothuri , Madhu Inapanuri , Sridhar Balasubramanian , Reddy Kallu Rajender 
Published: December 2023

AbstractA one‐pot synthesis of diversely substituted polycyclic fused 1,7‐naphthyridines has been achieved via a silver‐catalyzed domino reaction. In this protocol, ortho‐alkynyl quinolines/pyridines were reacted smoothly with substituted anthranilic acid/ anthranilamide and provided fused 1,7‐naphthyridines scaffolds in excellent yields and good functional group tolerance under mild conditions. This protocol is further applicable for gram scale synthesis. In this methodology, we proposed the mechanism with the help of control experiments.