bluuebunny/crossref_metadata_2025_split huggingface dataset:
MALDI-MS in first-line screening of newborns for sickle cell disease: results from a prospective study in comparison to HPLC
Authors: El Osta Marven , Benoist Jean-François , Naubourg Pierre , Bonacorsi Stéphane , Messine Reine , Ducoroy Patrick , Allaf Bichr 
Published: February 2024

Abstract

Objectives
Newborn screening (NBS) for sickle cell disease (SCD) requires a robust, high-throughput method to detect hemoglobin S (HbS). Screening for SCD is performed by qualitative methods, such as isoelectric focusing (IEF), and both qualitative and quantitative methods such as high performance liquid chromatography (HPLC), capillary electrophoresis (CE), and tandem mass spectrometry (MS/MS). All these methods detect HbS, as well as low-level or absent HbA, and also other variants of hemoglobin. HPLC is considered as a reference method for NBS, because of its high sensitivity and specificity in detecting HbS. NeoSickle®, a fully automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform, combined with automated sample processing, a laboratory information management system and NeoSickle® software for automatic data interpretation, has increased the throughput of SCD testing. The purpose of this study was to compare the performances of NeoSickle® and HPLC.

Methods
A prospective study was conducted including 9,571 samples from the NBS program to compare MALDI-MS using NeoSickle® with an HPLC method. Correlation between the two methods was studied. For the MALDI-MS method, sensitivity, specificity, NPV, and PPV were calculated.

Results
We found over 99.4 % correlation between the HPLC and MALDI-MS results. NeoSickle® showed 100 % of sensitivity and specificity in detecting SCD syndrome, leading to positive and negative predictive values of 100 %.

Conclusions
NeoSickle® is adapted to NBS for SCD, and can be used in first-line high-throughput screening to detect HbS, and beta-thalassemia major warning. When HbS is detected, second-line use of another specific method as HPLC is necessary.
Molecular-level investigation of the adsorption mechanisms of thiazolidinediones on Cu2O(111) surface: a first-principles DFT study
Authors: Lgaz Hassane , Lee Han-Seung 
Published: February 2024

Abstract
We have employed first principles DFT calculation with van der Waals (vdW) corrections to investigate the adsorption mechanism of thiazolidine-2,4-dione (TZD) substituted by 4-methylbenzylidene (MTZD) at 5-position and by an additional allyl group (ATZD) at 3-position on copper oxide surface (Cu2O(111)). Parallel configurations were found the most energetically stable geometries. The adsorption binding energy magnitudes predicted that ATZD outperformed MTZD by −0.11 eV. Our calculations indicated that O and S atoms of thiazolidine-2,4-dione nucleus significantly enhanced the chemical bonding of ATZD and MTZD with Cu2O(111) surface. Hydrogen bond interactions between Lewis base site at unsaturated O atom above the copper surface and TZD molecules are contributing to the stability of TZD molecules on Cu2O(111) surface. The adsorption induced-work function of different TZD adsorption configurations decreased from 4.563 eV (Cu2O(111)) to 4.114–4.373 eV due to electron transport between TZD molecules and Cu2O(111). The analysis of electronic properties of TZDs adsorption geometries revealed strong charge transfer and redistribution at the interface of TZDs-Cu2O(111), strengthening the stability of molecules on copper oxide surface. These theoretical insights would pave the way for further in-depth investigations into TZD-Copper interactions and provide valuable information for an optimized design of copper corrosion inhibitors.
On the generalized Mellin integral operators
Authors: Topuz Cem , Ozsarac Firat , Aral Ali 
Published: February 2024

Abstract
In this study, we give a modification of Mellin convolution-type operators. In this way, we obtain the rate of convergence with the modulus of the continuity of the

m

m

th-order Mellin derivative of function

f

f

, but without the derivative of the operator. Then, we express the Taylor formula including Mellin derivatives with integral remainder. Later, a Voronovskaya-type theorem is proved. In the last part, we state order of approximation of the modified operators, and the obtained results are restated for the Mellin-Gauss-Weierstrass operator.
On exact rate of convergence of row sequences of multipoint Hermite-Padé approximants
Authors: Bosuwan Nattapong 
Published: February 2024

Abstract
In this article, we analyze a rate of attraction of poles of an approximated function to poles of incomplete multipoint Padé approximants and use it to derive a sharp bound on the geometric rate of convergence of multipoint Hermite-Padé approximants to a vector of approximated functions in the Montessus de Ballore theorem when a table of interpolation points is Newtonian.
Zinc oxide-manganese oxide/carboxymethyl cellulose-folic acid-sesamol hybrid nanomaterials: A molecularly targeted strategy for advanced triple-negative breast cancer therapy
Authors: Zhao Chunming , Pan Xueqiang , Li Xiao , Li Meixia , Jiang Rui , Li Yuyang 
Published: February 2024

Abstract
Multifunctional nanocomposites (NC) can greatly enhance therapy outcomes by reducing tumor proliferative potential. We created a novel class of Zn_Mn_CMC_FA_sesamol NC in the current work to combat breast cancer (MDA-MB-231) cells. To understand how zinc (Zn), manganese (Mn), carboxymethylcellulose, and folic acid (FA) interact with sesamol, UV-Visible spectrophotometer and Fourier Transform Infrared spectroscopy were used to analyze the absorption behavior of the synthesized NC. The particle size of NC was confirmed by X-ray diffraction and dynamic light scattering. Scanning electron microscopy was used to assess the morphological features of these NCs. photoluminescence spectrum was used to analyze the optical and electron transition molecules of the sample. In addition to MTT analysis, acridine orange/ethidium bromide (AO/EtBr) analysis of reactive oxygen species (ROS) and nuclear staining with 4′,6-diamidino-2-phenylindole as well as flow cytometry were used to confirm the apoptotic activity of Zn_Mn_CMC_FA_sesamol NC on MDA-MB-231 cells. The results showed significant cytotoxicity, apoptosis induction on AO/EtBr, and increased ROS production in treated cells compared to control cells. The cell cycle analysis revealed that NCs triggered apoptosis and arrested the cell cycle in G0/G1 phases. As a conclusion, the created NC serves as a versatile platform for the successful molecularly targeted chemotherapeutic treatment of cancer.
Inter- and intra-growth ring variations of wood carbon fractions in Pinus tabuliformis
Authors: Wei Yupei , Zheng Chang , Ma Lingyu , Jiang Xiaomei , Yin Yafang , Guo Juan 
Published: February 2024

Abstract
Carbon fraction (CF) of trees is essential for quantifying forest carbon (C) stocks. Considerable attention has been paid to CF variations at various levels with the exception of inter- and intra-growth rings. Herein, the inter- and intra-growth ring variation of CF in Pinus tabuliformis was investigated. Elemental analysis was performed to obtain CF values of the earlywood and latewood in each growth ring of the xylem. Patterns of CF variation at the growth ring level were evaluated using mixed-effect models. The results showed that latewood CF, 50.6 %, was significantly higher than earlywood CF, 49.9 % (p < 0.01). In particular, inter-growth ring variations of CF differed between heartwood and sapwood, as well as between juvenile wood and mature wood. CF values decreased nonlinearly with cambium age toward the heartwood or juvenile wood, with estimated least-squares means of 50.4 % and 51.8 %, respectively. While CF values were almost unaltered in sapwood, and slightly decreased in mature wood, with estimated least-squares means of 50.0 % and 50.2 %, respectively. It indicates that patterns of CF variation between juvenile wood and mature wood are important to estimate the C stock of P. tabuliformis. This research provides insights into C uptake dynamics to support forest management and wood utilization.
In-depth analysis of Gαs protein activity by probing different fluorescently labeled guanine nucleotides
Authors: Pepanian Anna , Sommerfeld Paul , Binbay Furkan Ayberk , Fischer Dietmar , Pietsch Markus , Imhof Diana 
Published: February 2024

Abstract
G proteins are interacting partners of G protein-coupled receptors (GPCRs) in eukaryotic cells. Upon G protein activation, the ability of the Gα subunit to exchange GDP for GTP determines the intracellular signal transduction. Although various studies have successfully shown that both Gαs and Gαi have an opposite effect on the intracellular cAMP production, with the latter being commonly described as “more active”, the functional analysis of Gαs is a comparably more complicated matter. Additionally, the thorough investigation of the ubiquitously expressed variants of Gαs, Gαs(short) and Gαs(long), is still pending. Since the previous experimental evaluation of the activity and function of the Gαs isoforms is not consistent, the focus was laid on structural investigations to understand the GTPase activity. Herein, we examined recombinant human Gαs by applying an established methodological setup developed for Gαi characterization. The ability for GTP binding was evaluated with fluorescence and fluorescence anisotropy assays, whereas the intrinsic hydrolytic activity of the isoforms was determined by a GTPase assay. Among different nucleotide probes, BODIPY FL GTPγS exhibited the highest binding affinity towards the Gαs subunit. This work provides a deeper understanding of the Gαs subunit and provides novel information concerning the differences between the two protein variants.
Knowledge and beliefs of Greek parents towards HPV infection and vaccination – are they willing to vaccinate their sons?
Authors: Toska Aikaterini , Latsou Dimitra , Paraskeuopoulou Chrysoula , Fradelos Evangelos , Albani Eleni , Millionis Charalambos , Geitona Mary , Papagiannis Dimitrios , Saridi Maria 
Published: February 2024

Abstract

Objectives
Human papillomavirus (HPV) stands as one of the prevalent sexually transmitted infections (STIs) and serves as the primary factor behind nearly all instances of cervical cancer, along with various other non-cancerous conditions like genital warts. Our objective was to explore the knowledge and beliefs of Greek parents regarding HPV infection and the vaccination of boys against HPV.

Methods
A cross-sectional study took place at a university hospital located in the Peloponnese region of Greece, from January to June 2021. The study employed convenience sampling as its methodology, and data gathering involved the distribution of self-administered questionnaires to parents who had at least one son between the ages of 9 and 18 years.

Results
The final sample consisted of 120 individuals. 65.8 % of parents have been informed about HPV vaccination, knew that the HPV vaccine provides immunity against genital warts (50 %), and that minimum of two doses is necessary (46.7 %). 30.8 % intended to vaccinate their boys against HPV if the vaccine were available for males. The most important reasons for vaccination were the perception that both genders share equal responsibility in the prevention of sexually transmitted infections (91.7 %) and the protection against cancer (87.6 %), whereas the fear of adverse reactions and the adequate knowledge about HPV-related diseases were most reported as reasons of the intentions to not vaccinate their sons with 31.7 % and 25.8 % respectively.

Conclusions
Although parents participating in the study know about HPV, however, there are significant lack of knowledge regarding HPV infection and the vaccine effects, which can significantly affect the acceptance of vaccination for boys.
Power coordination control method for AC/DC hybrid microgrid considering demand response
Authors: Li Hongyu , Guo Xingyuan , Li Junwei 
Published: February 2024

Abstract
AC–DC hybrid microgrid consists of a variety of energy resources, different types of loads and storage devices, and involves the interconnection between AC and DC power grids. This leads to increased complexity in system design and coordination control, which needs to take into account the interactions and coordination between individual components. Considering the demand response, the power coordination control method of AC/DC hybrid microgrid is studied, which can effectively adjust the power of microgrid in different operation modes and ensure its smooth operation. Combined with the topology of AC/DC hybrid microgrid and its bidirectional converter, the constraints such as AC-side load demand response and AC/DC-side power balance are set on the premise of considering demand response. Under such constraints, the microgrid is divided into two modes: sub-network independent operation and inter-network power exchange. Corresponding control sections are designed for the two modes. On the premise of the set constraints, the microgrid power in each mode is coordinated by coordinating the control methods of the converters. The results show that this method can respond to several mode switches of AC/DC hybrid microgrid in time and effectively coordinate and control the power during the switching process under the constraint conditions such as load demand response. In addition, in the single mode of inter-network power exchange, this method can also quickly respond to the load demand, effectively adjust the exchange power between AC and DC subnets of microgrid, realize the reasonable distribution of power, and make the hybrid microgrid run stably in different modes. During the 8 s to 10 s phase of the experiment, the load power of the DC subnetwork of the experimental microgrid did not change, while the load power of the AC subnetwork increased to 36 kW, the reference power and converter power remained unchanged, and the microgrid voltage remained stable.
An idiodynamic study of the interconnectedness between cognitive and affective components underlying L2 willingness to communicate
Authors: Wang Yupei , Xu Quan 
Published: February 2024

Abstract
Employing the Complex Dynamic Systems Theory (CDST) as a theoretical framework, this study explores the interconnectedness of cognitive and affective components within the Willingness to Communicate (WTC) among eight undergraduate students in a university classroom in China. The eight students were divided into four pairs, engaging in a communication task in English, followed by self-ratings of WTC using software and stimulated recall interviews. Interconnectedness was examined on a per-second basis. Analysis of these interconnected interactions revealed five patterns across three states of WTC. Among the rising, stable, and declining states of WTC, cognitive issues (e.g., discrepancy in viewpoints, vocabulary retrieval, self-monitoring) dynamically interacted with affective instances (e.g., anger, excitement, and emotional dependence on the partner), influencing the pattern of interconnectedness. The findings suggest that interconnectedness in WTC exhibits reciprocal interaction and nonlinearity. Speculation within these intricate cognitive-affective interactions suggests that affective components may have a greater influence on determining the level of L2 WTC. These insights highlight the dynamic interplay between WTC components and the system as a whole, revealing their uneven influence on the WTC system.
Revivalism in the New Life Movement and Cultural Conservatism in Early Chinese Films, 1934–1937
Authors: Li Jiuru 
Published: February 2024

Abstract
During the period of 1934–1937, the cultural atmosphere of revivalism was magnified by the New Life Movement (新生活运动, Xinshenghuo yundong). Within this period, certain films of cultural conservatism (文化保守主义, Wenhua baoshou zhuyi) were produced. These films, whose modern significance has been overlooked until recently, tended to be treated simply in the traditional narrative of film history.
mRLWE-CP-ABE: A revocable CP-ABE for post-quantum cryptography
Authors: Cianfriglia Marco , Onofri Elia , Pedicini Marco 
Published: February 2024

Abstract
We address the problem of user fast revocation in the lattice-based Ciphertext Policy Attribute-Based Encryption (CP-ABE) by extending the scheme originally introduced by Zhang and Zhang [Zhang J, Zhang Z. A ciphertext policy attribute-based encryption scheme without pairings. In: International Conference on Information Security and Cryptology. Springer; 2011. p. 324–40. doi: https://doi.org/10.1007/978-3-642-34704-7_23.]. While a lot of work exists on the construction of revocable schemes for CP-ABE based on pairings, works based on lattices are not so common, and – to the best of our knowledge – we introduce the first server-aided revocation scheme in a lattice-based CP-ABE scheme, hence being embedded in a post-quantum secure environment. In particular, we rely on semi-trusted “mediators” to provide a multi-step decryption capable of handling mediation without re-encryption. We comment on the scheme and its application, and we provide performance experiments on a prototype implementation in the Attribute-Based Encryption spin-off library of Palisade to evaluate the overhead compared with the original scheme.
Two Turkish patients with Primary Coenzyme Q10 Deficiency-7: case report and literature review
Authors: Sonuç Kartal Gülreyhan , Koç Yekedüz Merve , Köse Engin , Eminoğlu Fatma Tuba 
Published: February 2024

Abstract

Objectives
Primary Coenzyme Q10 Deficiency-7 (OMIM 616276) results from bi-allelic pathogenic variants in the COQ4 gene. Common clinical findings include hypotonia, seizures, respiratory distress, and cardiomyopathy. In this report, we present two patients diagnosed with Primary Coenzyme Q10 Deficiency-7 along with a review of previously published cases, with the aim being to provide a better understanding of the clinical and laboratory manifestations of the disease.

Case presentation
A 3-month-and-22-day-old male was admitted to our outpatient clinic due to poor feeding and restlessness. He was born following an uneventful pregnancy to a nonconsanguineous marriage. A physical examination revealed hypotonia, a dolichocephaly, periorbital edema, and long eyelashes. Blood tests revealed metabolic acidosis and elevated serum lactate levels, while the genetic analysis revealed a variant previously reported as pathogenic, c.437T>G (p.Phe146Cys), in the COQ4 gene. Genetic tests were also conducted on both mother and father, and it revealed heterozygous variant, 0.437T>G (p.Phe146Cys), in the COQ4 gene. As a result of these findings, the patient was diagnosed with neonatal encephalomyopathy–cardiomyopathy–respiratory distress syndrome (Primary Coenzyme Q10 Deficiency-7). A 1-year-old male was admitted to our clinic with complaints of hypotonia, seizures, and feeding difficulties. He was born following an uneventful pregnancy to a nonconsanguineous marriage. On his first day of life, he was admitted to the neonatal intensive care unit due to poor feeding and hypotonia. A physical examination revealed microcephaly, a high palate, poor feeding, weak crying, hypotonia, bilateral horizontal nystagmus, and inability to maintain eye contact. Laboratory findings were within normal limits, while a whole exome sequencing analysis revealed a homozygous variant previously reported as pathogenic, c.458C>T (p.A153V), in the COQ4 gene. The patient was diagnosed with Primary Coenzyme Q10 Deficiency-7.

Conclusions
Primary Coenzyme Q10 Deficiency-7 should be considered in the differential diagnosis of infants presenting with neurological and dysmorphic manifestations.
Religious diversity and culturally responsive learning and teaching for teacher candidates
Authors: Hwang Yooyeun , Wolthuis Ronald M. , Kasap Süleyman , Peterson Richard M. 
Published: February 2024

Abstract
Eleven teacher candidates who attended a Christian liberal arts college in the U.S. met a group of Turkish college students who were Muslim weekly via Zoom at least six times. These Turkish students were future English teachers, and the American students served as English conversation partners. The present study investigated the effectiveness of a program that could facilitate positive interactions between different religious groups and an in-depth understanding of culturally responsive teaching. Student reviews, two surveys before and after the program, and in-depth interviews revealed that the American students benefited from the experiences. They learned about distinct cultural traditions and the religion of Islam, discovered the similarities shared by the U.S, and Turkish cultures, appreciated both aspects, and became friends. In addition, they showed an authentic understanding of culturally responsive learning and teaching. The study suggests that the program enhanced cultural sensitivity, including to religious diversity, and the appreciation of culturally responsive learning and teaching among teacher candidates.
The crystal structure of (E)-1,2-bis(benzo[e][1,2]azaborinin-2(1H)-yl)ethene, C18H16B2N2
Authors: Zhou Jing 
Published: February 2024

Abstract
C18H16B2N2, monoclinic, C2/c (no. 15), a = 34.048(12) Å, b = 5.720(2) Å, c = 7.666(3) Å, β = 96.803°, V = 1482.5(9) Å3, Z = 4, R

gt
(F) = 0.0412, wR

ref
(F
2) = 0.1152, T = 150 K.
Dual numerical solutions of Casson SA–hybrid nanofluid toward a stagnation point flow over stretching/shrinking cylinder
Authors: Fadhel Mustafa Abbas , Asghar Adnan , Lund Liaquat Ali , Shah Zahir , Vrinceanu Narcisa , Tirth Vineet 
Published: February 2024

Abstract
A computational study of Casson sodium alginate–hybrid nanofluid of stagnation point flow through a shrinking/stretching cylinder with radius effect was carried out. Since the hybrid nanofluid is considered more contemporary type of nanofluid, it is currently being employed to enhance the efficiency of heat transmission rates. The aim of this study is to scrutinize the effect of particular parameters, such as the shrinking parameter, the Reynold number, the Casson fluid parameter, the solid copper volume fraction, and the Prandtl number, on the temperature and velocity profiles. Furthermore, the research looked into the variation of skin friction coefficient as well as the Nusselt number according to the Casson fluid parameters, and the copper solid volume fraction against shrinking parameter was investigated as part of this study. By including the appropriate similarity variables in the alteration, the nonlinear partial differential equation has been transformed into a set of ordinary differential equations (ODEs). In the end, the MATLAB bvp4c solver program is used to rectify ODEs. The findings revealed the existence of two solutions for shrinking surface with varying copper volume fractions and Casson fluid parameter values. Furthermore, the temperature profile rate was reduced in both solutions as the strength of the Reynold number, Casson fluid parameter, and copper volume fraction increased. Finally, non-unique solutions were obtained in the range of

λ
≥

λ

ci

\lambda \ge {\lambda }_{{\rm{ci}}}

.