bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Related Macular Degeneration
Authors: Fleckenstein Monika , Schmitz-Valckenberg Steffen , Chakravarthy Usha 
Published: January 2024

ImportanceAge-related macular degeneration (AMD) affects approximately 20 million people in the US and 196 million people worldwide. AMD is a leading cause of severe vision impairment in older people and is expected to affect approximately 288 million people worldwide by 2040.ObservationsOlder age, genetic factors, and environmental factors, such as cigarette smoking, are associated with development of AMD. AMD occurs when extracellular deposits accumulate in the outer retina, ultimately leading to photoreceptor degeneration and loss of central vision. The late stages of AMD are characterized by outer retinal atrophy, termed geographic atrophy, or neovascularization associated with subretinal and/or intraretinal exudation, termed exudative neovascular AMD. The annual incidence of AMD ranges from 0.3 per 1000 in people who are aged 55 to 59 years to 36.7 per 1000 in people aged 90 years or older. The estimated heritability of late-stage AMD is approximately 71% (95% CI, 18%-88%). Long-term prospective cohort studies show a significantly higher AMD incidence in people who smoke more than 20 cigarettes per day compared with people who never smoked. AMD is diagnosed primarily with clinical examination that includes a special lens that focuses light of the slit lamp through the pupil. Exudative neovascular AMD is best identified using angiography and by optical coherence tomography. Individuals with AMD who take nutritional supplements consisting of high-dose vitamin C, vitamin E, carotenoids, and zinc have a 20% probability to progress to late-stage AMD at 5 years vs a 28% probability for those taking a placebo. In exudative neovascular AMD, 94.6% of patients receiving monthly intravitreal anti–vascular endothelial growth factor (anti-VEGF) injections experience less than a 15-letter visual acuity loss after 12 months compared with 62.2% receiving sham treatment.Conclusions and RelevanceThe prevalence of AMD is anticipated to increase worldwide to 288 million individuals by 2040. Intravitreally administered anti-VEGF treatment is first-line therapy for exudative neovascular AMD.
Versatile Agar‐Zwitterion Hybrid Hydrogels for Temperature Self‐Sensing and Electro‐Responsive Actuation
Authors: Yang Jueying , Huang Weiting , Peng Kelin , Cheng Zhekun , Lin Lizhi , Yuan Jingjing , Sun Yi , Cho Nam‐Joon , Chen Yu 
Published: January 2024

AbstractAlthough recent years have seen considerable interest in stimuli‐responsive hydrogels, their strict preparation conditions and narrow applicability limit their use as diverse sensors and soft robots. Herein, a versatile Agar‐Zwirrions hybrid hydrogel actuator (Agar/PSBMA) integrated with simultaneous temperature self‐sensing and wide‐range electrical response is developed. To prepare the Agar/PSBMA hydrogel, a simple and controllable preforming post‐enhancing and mechanical pressing method is used by introducing zwitterions materials into a temperature‐sensitive Agar matrix. Owing to the design, the compact multiplex complementary structure generated by this method and the materials can facilitate the improvement of flexibility, stretchability, and toughness while providing mechanical dissipation and adhesion properties. Importantly, the visible detected temperature self‐sensing ability during 10–40 °C, and quick and wide‐range bending responses of both high‐voltage and low‐voltage electric fields make it unique over other actuators. Furthermore, the electrical response behavior of the hydrogel is found to be impacted by mechanical characteristics and charge polarization based on the finite element Abaqus simulations analysis. The prepared versatile hydrogels show the potential for applications as soft robotics and controlled transportation of adhered substances while simultaneously monitoring their working temperature, which expands the response range of hydrogel actuators and broadens the scope of application.
Establishing Multiple‐Order Built‐In Electric Fields Within Heterojunctions to Achieve Photocarrier Spatial Separation
Authors: Xue Sikang , Tang Hao , Shen Min , Liang Xiaocong , Li Xiaoyan , Xing Wandong , Yang Can , Yu Zhiyang 
Published: January 2024

AbstractHybridizing two heterocomponents to construct a built‐in electric field (BIEF) at the interface represents a significant strategy for facilitating charge separation in carbon dioxide (CO2)‐photoreduction. However, the unidirectional nature of BIEFs formed by various low‐dimensional materials poses challenges in adequately segregating the photogenerated carriers produced in bulk. In this study, leveraging zinc oxide (ZnO) nanodisks, a sulfurization reaction is employed to fabricate Z‐scheme ZnO/zinc sulfide (ZnS) heterojunctions featuring a multiple‐order BIEF. These heterojunctions reveal distinctive interfacial structures characterized by two semicoherent phase boundaries. The cathodoluminescence 2D maps and density functional theory calculation results demonstrate that the direction of the multiple‐order BIEF spans from ZnS to ZnO. This directional alignment significantly fosters the spatial separation of photogenerated electrons and holes within ZnS nanoparticles and enhances CO2‐to‐carbon monoxide photoreduction performance (3811.7 µmol h−1 g−1). The findings present a novel pathway for structurally designing BIEFs within heterojunctions, while providing fresh insights into the migratory behavior of photogenerated carriers across interfaces.
Combining 3D Printing and Cryostructuring to Tackle Infection and Spine Fusion
Authors: Fischetti Tiziana , Graziani Gabriela , Ghezzi Daniele , Kaiser Friederike , Hoelscher‐Doht Stefanie , Cappelletti Martina , Barbanti‐Bròdano Giovanni , Groll Jürgen , Baldini Nicola , Gbureck Uwe , Jungst Tomasz 
Published: January 2024

AbstractLow back pain is among the main issues in vertebral orthopaedics. Intervertebral disk degeneration can be severe, up to requiring the replacement of the damaged disk by substitutes to achieve spine fusion. Disk removal results in critical size defects, so fusion does not occur naturally, but synthetic bone grafts are needed. Since the surgical procedure is time‐consuming, high infection rates occur. Hence, in spine fusion, bone regeneration enhancement and infection prevention are needed. Here, a new dual‐component system is proposed, to tackle both issues at one time. To enable spine fusion, 3D extrusion‐based printing is employed to develop coherent custom magnesium phosphate (CaMgP)‐based cages. The 3D‐printed scaffolds are hardened, and the structural properties are evaluated to be within the ranges of physiological bone. To prevent infection, an in‐house ice‐templating device is employed in combination with a 3D‐printed ceramic scaffold, to develop tailored porous alginate structures loaded with vancomycin. Results show that CaMgP can be printed into complex geometries and that the geometry influences the pore orientation during ice‐templating. These structures loaded with vancomycin have antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) strains.
Salivary alpha‐amylase stress reactivity in advanced‐aged marmosets (Callithrix jacchus): Impacts of cognitive function and oral health status
Authors: Sarmet Max , Takehara Sachiko , de Campos Priscila S. , Kagiyama Kensuke , Borges Luana S. , Kumei Yasuhiro , Zeredo Jorge L. L. 
Published: January 2024

AbstractSalivary alpha‐amylase (sAA) is an enzyme found in saliva and is considered a noninvasive biomarker for sympathetic nervous system activity. While a wide range of sAA activity in response to stress has been reported in nonhuman primates, the effects of stress on sAA activity in common marmosets are still unknown. We tested the hypothesis that advanced age and cognitive function may have an impact on stress‐related sAA reactivity in marmosets. Thirteen marmosets (nine males and five females) had saliva samples collected during a stressful condition (manual restraint stress) at two different time points, with a 60‐min interval. On the next day, the animals underwent the object recognition test (ORT, a type of cognitive test), and then oral examinations. The animals were categorized into two age groups: old (10–13 years), and very old (15–22 years). Irrespective of age, sAA levels showed a significant difference between T1 (mean 2.07 ± 0.86 U/mL) and T2 samples (mean 1.03 ± 0.67 U/mL), with higher values observed at T1 (p < 0.001). The intra‐assay coefficients of variation (CV) for low and high sAA concentrations were 10.79% and 8.17%, respectively, while the interassay CVs for low and high sAA concentrations were 6.39% and 4.38%, respectively. Oral health issues were common but did not significantly impact sAA levels. The ORT indicated that the animals could recognize an object placed in the cage 6 h after familiarization. In conclusion, all marmosets showed a higher sAA concentration in the first saliva sample as compared to the second saliva sample collected 1 h later, indicating adaptation to stress. No significant differences in sAA levels were observed between sexes, ORT performance, or oral health. Our results indicate that autonomic responsivity and cognitive (memory) functions were preserved even in very old marmosets.
Ultrasensitive Plasmon‐Enhanced Infrared Spectroelectrochemistry
Authors: Li Jin , Wu Dan , Li Jian , Zhou Yue , Yan Zhendong , Liang Jing , Zhang Qing‐Ying , Xia Xing‐Hua 
Published: January 2024

AbstractIR spectroelectrochemistry (EC‐IR) is a cutting‐edge operando method for exploring electrochemical reaction mechanisms. However, detection of interfacial molecules is challenged by the limited sensitivity of existing EC‐IR platforms due to the lack of high‐enhancement substrates. Here, we propose an innovative plasmon‐enhanced infrared spectroelectrochemistry (EC‐PEIRS) platform to overcome this sensitivity limitation. Plasmonic antennae with ultrahigh IR signal enhancement are electrically connected via monolayer graphene while preserving optical path integrity, serving as both the electrode and IR substrate. The [Fe(CN)6]3−/[Fe(CN)6]4− redox reaction and electrochemical CO2 reduction reaction (CO2RR) are investigated on the EC‐PEIRS platform with a remarkable signal enhancement. Notably, the enhanced IR signals enable a reconstruction of the electrochemical curve of the redox reactions and unveil the CO2RR mechanism. This study presents a promising technique for boosting the in‐depth understanding of interfacial events across diverse applications.
Tailoring interfacial adhesion and mechanical performance of biocomposites based on poly(lactic acid)/rice straw by using maleic anhydride through reactive extrusion process
Authors: Asheghi‐Oskooee Reza , Morsali Parisa , Mohammadi‐Roshandeh Jamshid , Hemmati Farkhondeh 
Published: January 2024

AbstractIn this study, all‐green biocomposites based on poly(lactic acid) (PLA)/rice straw (RS) as an agricultural waste were prepared, and the physical, structural, and mechanical properties of these biocomposites were enhanced by alkali‐pulping of RS and chemical grafting of PLA onto the lignocellulosic fiber. The reactive compatibilizers of maleic anhydride grafted PLA (PLA‐g‐MA) were obtained through a reactive extrusion process at different processing conditions. The probable chemical reactions between the functional groups of PLA‐g‐MA with hydroxyl groups of RS pulp as well as the end groups of PLA chains can effectively improve the interfacial adhesion between the filler and matrix. However, the findings confirm the great importance of PLA‐g‐MA chemical structure in controlling the biocomposite performance. By choosing proper processing conditions for preparing PLA‐g‐MA and incorporating this compatibilizer into the PLA/treated RS biocomposite, Young modulus, tensile strength, impact strength, and tensile toughness of the PLA/RS biocomposite increased by 101%, 156%, 96%, and 327%, respectively.
The merged and superposed sub‐tropical jet and polar‐front jet in the southwest Pacific: A case study
Authors: Yang Y. , Carey‐Smith T. , Turner R. 
Published: January 2024

AbstractIn the southwest Pacific, a meandering jet‐stream in the upper troposphere is sometimes found at ~30° S during austral winters and is usually treated as a sub‐tropical jet (STJ) due to its low latitude. For two contrasting cases, we have conducted analyses from two perspectives to identify the STJ and PFJ: first, using previously published qualitative criteria to identify jet‐cores and second, investigating the jet‐stream axes of STJ and PFJ identified using 2‐PVU curves. The results showed that the chosen meandering jet‐stream case at ~30° S was a merged, and for a time, a superposed STJ and PFJ. Downstream of the jet‐streak, the PFJ split to the south and the STJ to the east. This is in significant contrast to the horizontally well‐separated jet‐stream case chosen in this study. Some processes likely contributing to the superposition of the STJ and PFJ were analyzed and discussed. The movement of PFJ that was closely associated with the movement of the low over the Tasman Sea and the convection in and near the tropical region may have played dominant roles.
Clinical factor‐based risk stratification for precision therapy in locally advanced squamous cell carcinoma of the uterine cervix
Authors: Liu Feng‐Yuan , Chen Wei‐Chun , Pan Yu‐Bin , Wang Chun‐Chieh , Tang Yun‐Hsin , Chou Hung‐Hsueh , Chao Angel , Yang Lan‐Yan , Lai Chyong‐Huey 
Published: January 2024

AbstractBackgroundConcurrent chemoradiotherapy (CCRT) is the standard of care for locally advanced cervical cancer. In this study, we analyzed the pretreatment clinical and 18F‐fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) characteristics of patients with locally advanced cervical squamous cell carcinoma (SCC) to develop a scoring prototype for risk stratification.MethodsTwo cohorts were constructed in this study. Cohort 1 comprised patients with cervical SCC with 2009 FIGO stage III‐IVA or stage I–II with positive pelvic or para‐aortic lymph node (PALN) on PET/CT from AGOG09‐001 trial. Cohort 2 comprised patients with similar characteristics who had received adequate therapy in our hospital between 2016 and 2021. Pretreatment patient characteristics and PET/CT parameters including maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) of primary tumor and nodal SUVmax were assessed for cancer‐specific survival (CSS) using multivariate Cox regression.ResultsAnalysis of combined data from cohorts 1 (n = 55) and 2 (n = 128) indicated age ≥ 66 years, primary tumor MTV ≥87 mL, and positive PALN on PET/CT to be independently significant adverse predictors for CSS (p < 0.001, p = 0.014, and p = 0.026, respectively) with a median follow‐up duration of 51 months. Assigning a score of 1 to each adverse predictor, patients with cumulative risk scores of 0, 1, 2, and 3 were discovered to have a 5‐year CSS of 86.9%, 71.0%, 32.2%, and 0%, respectively (p < 0.001).ConclusionAge, primary tumor MTV, and positive PALN on PET/CT may serve as independent predictors of poor survival in patients with locally advanced cervical SCC. Our findings indicate that patients without any adverse factors can receive standard CCRT, whereas those with at least one adverse factor can consider novel combination therapies or clinical trials.
Fear of cancer recurrence in breast cancer survivors carrying a BRCA1/2 mutation: A qualitative study
Authors: Savard Josée , Filion Catherine , Brearty Claudia Mc , Caplette‐Gingras Aude , Chiquette Jocelyne , Dorval Michel 
Published: January 2024

AbstractBackgroundThere is preliminary evidence suggesting that FCR is a major problem for breast cancer survivors carrying a BRCA1/2 mutation. The goal of this qualitative study, conducted among women who were treated for breast cancer, was to provide a deeper understanding of how FCR is experienced in the context of a genetic predisposition to breast cancer.MethodThree focus groups (90–110 min) were conducted with 19 breast cancer survivors carrying a BRCA1/2 mutation. The semistructured interview probed FCR level and impact, the role FCR played in the decision to have a prophylactic bilateral mastectomy and/or salpingo‐oophorectomy, the effect that surgery had on FCR, and the relevance of offering a psychological intervention targeting FCR to this population.ResultsFindings indicated that FCR was a significant issue in these women, even though a majority had undergone a prophylactic surgery. Patients strongly affirmed the need to develop and provide access to FCR interventions that are specifically adapted to the needs of this group.DiscussionThese results suggest that, although being the most effective medical option to reduce the actual risk of local recurrence (or second breast cancer), prophylactic surgery only partially reduces FCR. A psychological intervention targeting specifically FCR would be an appropriate complement to preventive surgery.
LC‐HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies
Authors: El‐Hawary Seham S. , Hassan Marwa H. A. , Hudhud Ahmed O. , Al‐Karmalawy Ahmed A. , Mustafa Muhamad , Hamed Elsayed A. E. , Abdelmohsen. Usama Ramadan , Mohammed Rabab 
Published: January 2024

AbstractIn the current study, the actinomycetes associated with the red sea‐derived soft coral Sarcophyton glaucum were investigated in terms of biological and chemical diversity. Four different media, M1, ISP2, Marine Agar (MA), and Actinomycete isolation agar (AIA) were used for the isolation of three strains of actinomycetes that were identified as Streptomyces sp. UR 25, Micromonospora sp. UR32 and Saccharomonospora sp. UR 19. LC‐HRMS analysis was used to investigate the chemical diversity of the isolated actinobacteria. The LC‐HRMS data were statistically processed using MetaboAnalyst 5.0 viz to differentiate the extract groups and determine the optimal growth culturing conditions. Multivariate data statistical analysis revealed that the Micromonospora sp. extract cultured on (MA) medium is the most distinctive extract in terms of chemical composition. While, the Streptomyces sp. UR 25 extracts are differ significantly from Micromonospora sp. UR32 and Saccharomonospora sp. UR 19. Biological investigation using in vitro cytotoxic assay for actinobacteria extracts revealed the prominent potentiality of the Streptomyces sp. UR 25 cultured on oligotrophic medium against human hepatoma (HepG2), human breast adenocarcinoma (MCF‐7) and human colon adenocarcinoma (CACO2) cell lines (IC50=3.3, 4.2 and 6.8 μg/mL, respectively). SwissTarget Prediction speculated that among the identified compounds, 16‐deethyl, indanomycin (8) could have reasonable affinity on HDM2 active site. In this respect, molecular docking study was performed for compound (8) to reveal a substantial affinity on HDM2 active site. In addition, molecular dynamics simulations were carried out at 200 ns for the most active compound (8) compared to the co‐crystallized inhibitor DIZ giving deeper information regarding their thermodynamic and dynamic properties as well.
Sustainable Point of View: Life Cycle Analysis for Green Extraction Technologies
Authors: Aslanbay Guler Bahar , Tepe Ugur , Imamoglu Esra 
Published: January 2024

AbstractMicroalgae have emerged as a promising source of renewable energy and natural bioproducts since they show high biomass productivity, offer carbon dioxide fixation, and exhibit a rich content of compounds. Recent efforts have focused on green extraction technologies that utilize green solvents to further promote sustainability and minimize the environmental impact of the microalgal process. At this point, life cycle analysis (LCA) provides valuable insights into the environmental impacts of specific products and techniques. A comprehensive overview of the life cycle environmental and energy assessments conducted for the extraction of metabolites from microalgae is presented. Special attention is given to using green extraction technologies, i.e., supercritical fluid extraction, pressurized liquid extraction, microwave‐assisted extraction, ultrasound‐assisted extraction, and pulsed‐electric field extraction, and solvents to ensure sustainability. Additionally, the main principles, historical development, tools, and challenges of LCA are discussed. By addressing these aspects, the paper attracts attention to the environmental impacts associated with green extraction techniques for obtaining microalgal metabolites.
Effectiveness and safety of ivabradine in Chinese patients with chronic heart failure: an observational study
Authors: Zhou Jingmin , Xu Yamei , Zheng Zhaofen , Zhang Shuyang , Yang Jiefu , Zhang Yuhui , Tang Baopeng , Han Huiyuan , Zhang Qing , Liu Fan , Ding Wenhui , Qian Caizhen , Su Guohai , Liu Xiaohui , Shen Yuansheng , Shi Bei , Kong Xiangqing , Ge Zhiming , Zhang Ping , Guo Xiaomei , Zhang Hong , Sun Yuemin , Dong Yugang , Fu Guosheng , Feng Lei , Ge Junbo ,   the POSITIVE investigators
Published: January 2024

AbstractAimsA therapeutic strategy for chronic heart failure (HF) is to lower resting heart rate (HR). Ivabradine is a well‐known HR‐lowering agent, but limited prospective data exist regarding its use in Chinese patients. This study aimed to evaluate the effectiveness and safety of ivabradine in Chinese patients with chronic HF.Methods and resultsThis multicentre, single‐arm, prospective, observational study enrolled Chinese patients with chronic HF. The primary outcome was change from baseline in HR at 1 and 6 months, measured by pulse counting. Effectiveness was also evaluated using laboratory tests, the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score (CSS) and overall summary score (OSS), and New York Heart Association (NYHA) class. Treatment‐emergent adverse events (TEAEs) were assessed. A post hoc analysis examined the effectiveness and safety of ivabradine combined with an angiotensin receptor–neprilysin inhibitor (ARNI) or beta‐blocker. A total of 1003 patients were enrolled [mean age 54.4 ± 15.0 years, 773 male (77.1%), mean baseline HR 88.5 ± 11.3 b.p.m., mean blood pressure 115.7/74.4 ± 17.2/12.3 mmHg, mean left ventricular ejection fraction 30.9 ± 7.6%, NYHA Classes III and IV in 48.8% and 22.0% of patients, respectively]. HR decreased by a mean of 12.9 and 16.1 b.p.m. after 1 and 6 months, respectively (both P < 0.001). At Month 6, improvements in the KCCQ CSS and OSS of ≥5 points were observed in 72.1% and 74.1% of patients, respectively (both P < 0.001). Left ventricular ejection fraction increased by 12.1 ± 11.6 (P < 0.001), and 66.7% of patients showed improvement in NYHA class (P < 0.001). At Month 6, the overall proportion of patients in NYHA Classes III and IV was reduced to 13.5% and 2.1%, respectively. Serum brain natriuretic peptide (BNP) and N‐terminal pro‐BNP changed by −331.9 ng/L (−1238.6, −134.0) and −1113.8 ng/L (−2202.0, −297.2), respectively (P < 0.001). HR reductions and improvements in NYHA and KCCQ scores with ivabradine were similar with and without use of ARNIs or beta‐blockers. Of 498 TEAEs in 296 patients (29.5%), 73 TEAEs in 55 patients (5.5%) were considered related to ivabradine [most frequent sinus bradycardia (n = 7) and photopsia (n = 7)]. TEAEs were reported in a similar number of patients in ARNI and beta‐blocker subgroups (21.9–35.6%).ConclusionsIvabradine treatment reduced HR and improved cardiac function and health‐related quality of life in Chinese patients with chronic HF. Benefits were seen irrespective of whether or not patients were also taking ARNIs or beta‐blockers. Treatment was well tolerated with a similar profile to previous ivabradine studies.