bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-0.3 volt amorphous metal WNx based NEMS switch with 8 trillion cycles
Authors: Mayet Abdulilah Mohammad , Muqeet Mohammed Abdul , Alhashim Hala H. , Kurdahi Fadi , Eftekhari-Zadeh Ehsan 
Published: January 2024

Introduction: The mechanical nature of nanoelectromechanical (NEM) switches makes them sluggish yet desirable for ultra-low-power, harsh environment applications. Two- and three-terminal NEM switches have been demonstrated using onedimensional, two-dimensional, and thin films, but sub-0.3 V operation with improved mechanical and electrical reliability is still elusive.Method: This study presents WNxnano-ribbon-based NEM sensor switches that operate at 0.6 V, 30 nanosecond switching time, 8 trillion cycles, and 0.5 mA ON current with less than 5 kΩ ON resistance, without stiction, mechanical welding, or short circuits. WNx’s high Young’s modulus gives it great elasticity and mechanical restoring force, which may overcome van der Waal and capillary forces.Results and Discussion: With its high Young’s modulus, the device’s nanoscale size facilitated low operating voltage. WNxnano-ribbon without grain boundaries is amorphous and more mechanically strong. Hammering and high current flow may destroy the nano-ribbon contact surface and interface, which is practically immaculate. Pull-out time (dominant delay factor) is 0 owing to high Young’s modulus, hence hysteresis loss and delay are absent. Elasticity and Young’s modulus increase speed.
Human resource implications of expanding latent tuberculosis patient care activities
Authors: Alsdurf Hannah , Benedetti Andrea , Buu Tran Ngoc , Adjobimey Menonli , Cook Victoria J. , Fisher Dina , Fox Gregory , Fregonese Federica , Hadisoemarto Panji , Johnston James , Long Richard , Obeng Joseph , Oxlade Olivia , Ruslami Rovina , Schwartzman Kevin , Strumpf Erin , Menzies Dick 
Published: January 2024

IntroductionThe World Health Organization (WHO) declared increasing services for latent tuberculosis infection (LTBI) a priority to eliminate tuberculosis (TB) by 2035. Yet, there is little information about thehuman resource needs required to implement LTBI treatment scale-up. Our study aimed to estimate the change in healthcare workers (HCW) time spent on different patient care activities, following an intervention to strengthen LTBI services.MethodsWe conducted a time and motion (TAM) study, observing HCW throughout a typical workday before and after the intervention (Evaluation and Strengthening phases, respectively) at 24 health facilities in five countries. The precise time spent on pre-specified categories of work activities was recorded. Time spent on direct patient care was subcategorized as relating to one of three conditions: LTBI, active or suspected TB, and non-TB (i.e., patients with any other medical condition). A linear mixed model (LMM) was fit to estimate the change in HCW time following the intervention.ResultsA total of 140 and 143 HCW participated in the TAMs during the Evaluation and Strengthening phases, respectively. Results from intervention facilities showed an increase of 9% (95% CI: 3%, 15%) in the proportion of HCW time spent on LTBI-related services, but with a corresponding change of -11% (95% CI: -21%, -1%) on active TB services. There was no change in the proportion of time spent on LTBI care in control facilities; this remained low in both phases of the study.DiscussionOur findings suggest that additional HCW personnel will be required for expansion of LTBI services to ensure that this expansion does not reduce the time available for care of active TB patients.
Validation of targeted next-generation sequencing panels in a cohort of Polish patients with epilepsy: assessing variable performance across clinical endophenotypes and uncovering novel genetic variants
Authors: Badura-Stronka Magdalena , Wołyńska Katarzyna , Winczewska-Wiktor Anna , Marcinkowska Justyna , Karolewska Dagmara , Tomkowiak-Kędzia Danuta , Piechota Michał , Przyborska Marta , Kochalska Natalia , Steinborn Barbara 
Published: January 2024

IntroductionTargeted Next-Generation Sequencing Panels (TNGSP) have become a standard in global clinical practice. Instead of questioning the necessity of next-generation sequencing in epilepsy patients, contemporary large-scale research focuses on factors such as the size of TNGSP, the comparative advantages of exome or genome-wide sequencing over TNGSP, and the impact of clinical, electrophysiological, and demographic variables on genetic test performance. This study aims to elucidate the demographic and clinical factors influencing the performance of TNGSP in 138 Polish patients with epilepsy, recognizing the pivotal role of genetic testing in guiding patient management and therapy.MethodsA retrospective analysis was conducted on patients from a genetic clinic in Poznań, Poland, who underwent commercial gene panel studies at Invitae Corporation (USA) between 2020 and 2022. Patient groups were defined based on the age of onset of the first epileptic seizures, seizure type, gender, fever dependence of seizures, presence of intellectual disability or developmental delay, abnormalities in MRI, and the presence of dysmorphic features or congenital malformations. Seizure classification followed the 2017 ILAE criteria.ResultsAmong the 138 patients, 30 (21.7%) exhibited a pathogenic or likely pathogenic variant, with a distribution of 20.7% in males and 22.5% in females. Diagnostic performance correlated with the patient’s age at the onset of the first seizure and the type of seizure. Predominant variants were identified in the SCN1A, PRRT2, CDKL5, DEPDC5, TSC2, and SLC2A1 genes. Additionally, 12 genes (CACNA1A, SCN2A, GRIN2A, KCNQ2, CHD2, DYNC1H1, NEXMIF, SCN1B, DDX3X, EEF1A2, NPRL3, UBE3A) exhibited single instances of damage. Notably, novel variants were discovered in DEPDC5, SCN1A, TSC2, CDKL5, NPRL3, DYNC1H1, CHD2, and DDX3X.DiscussionIdentified variants were present in genes previously recognized in both European and non-European populations. A thorough examination of Variants of Uncertain Significance (VUSs), specifically focusing on gene copy number changes, may unveil more extensive chromosomal aberrations. The relatively frequent occurrence of pathological variants in X chromosome-linked genes in girls warrants further investigation, challenging the prevailing notion of male predominance in X-linked epilepsy.
Enhancing nutritional value and health benefits of gluten-free confectionery products: innovative pastilles and marshmallows
Authors: Pronina Yuliya , Belozertseva Olga , Nabiyeva Zhanar , Pirozzi Annachiara , Carpentieri Serena , Ferrari Giovanna , Bazylkhanova Elmira , Burlyayeva Anastasiya 
Published: January 2024

IntroductionThe research focuses on enhancing the nutritional value and potential health benefits of gluten-free confectionery products, developing innovative pastilles and marshmallows enriched with medicinal herb extracts, probiotics, and bioactive compounds from natural sources.MethodsPhysicochemical properties, including water activity, texture, and color, are assessed to evaluate the quality of the final products. Moreover, in vitro digestibility of the confectionery products is also investigated, with a focus on the release of bioactive compounds such as total phenolic compounds (TPC) and total anthocyanin (TAC) during simulated gastrointestinal digestion.Results and discussionResults indicate that the addition of specific ingredients to pastille samples does not lead to variations in water activity (~0.44), preserving the original properties, quality, and stability of the food. In contrast, the incorporation of additives in marshmallow products significantly increases water activity (p ≤ 0.05), attributed to their moisture-retaining effect. In general, our findings reveal that texture properties and color parameters are significantly affected by different formulations (p ≤ 0.05) for both confectionery products. Notably, the use of fruit and berries puree, along with the incorporation of additives, improves the functionality of confectionary products in terms of consumer acceptance (harder pastilles and softer marshmallow) and product quality. Furthermore, the study reveals that bioactive compounds are released and become more bioaccessible during digestion, particularly in the intestinal phase, with a maximum release exceeding 97% of TPC and TAC for both pastille and marshmallow samples. These findings pave the way for the development of a new category of gluten-free confectionery products, enriched with functional ingredients that offer potential health benefits, aligning with consumer preferences for natural, functional, and health-conscious treats. This research contributes to the evolving the landscape of functional confectionery products and underscores their potential as immune-boosting and naturally based food options.
Primary mediastinal Ewing’s sarcoma presenting with sudden and severe chest pain: a case report
Authors: Su Chen , Zhu Xiaobo , Zhang Junjie 
Published: January 2024

Ewing’s sarcoma, characterized by small round cell morphology, is a rare malignancy, with mediastinal Ewing’s sarcoma being even less common. This case describes a distinctive presentation of primary mediastinal Ewing’s sarcoma in a 32-year-old male presenting with sudden and severe chest pain. Initial evaluation excluded cardiac and pulmonary emergencies, revealing a posterior mediastinal mass through advanced imaging. The patient’s clinical symptoms significantly improved following the complete resection of the tumor via thoracoscopy. Subsequent analysis incorporating imaging, histological, immunohistochemical and genetic findings led to the conclusive diagnosis of primary mediastinal Ewing’s sarcoma.
Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone
Authors: Balsera-Manzanero María , Ghirga Francesca , Ruiz-Molina Ana , Mori Mattia , Pachón Jerónimo , Botta Bruno , Cordero Elisa , Quaglio Deborah , Sánchez-Céspedes Javier 
Published: January 2024

Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity in immunosuppressed patients, a specific treatment is still not yet available. In this study, we screened the CM1407 COST Action’s chemical library, comprising 1,233 natural products to identify compounds that restrict HAdV infection. Among them, we identified rotenolone, a compound that significantly inhibited HAdV infection. Next, we selected four isoflavonoid-type compounds (e.g., rotenone, deguelin, millettone, and tephrosin), namely rotenoids, structurally related to rotenolone in order to evaluate and characterized in vitro their antiviral activities against HAdV and human cytomegalovirus (HCMV). Their IC50 values for HAdV ranged from 0.0039 µM for rotenone to 0.07 µM for tephrosin, with selective indices ranging from 164.1 for rotenone to 2,429.3 for deguelin. In addition, the inhibition of HCMV replication ranged from 50% to 92.1% at twice the IC50 concentrations obtained in the plaque assay for each compound against HAdV. Our results indicated that the mechanisms of action of rotenolone, deguelin, and tephrosin involve the late stages of the HAdV replication cycle. However, the antiviral mechanism of action of rotenone appears to involve the alteration of the microtubular polymerization, which prevents HAdV particles from reaching the nuclear membrane of the cell. These isoflavonoid-type compounds exert high antiviral activity against HAdV at nanomolar concentrations, and can be considered strong hit candidates for the development of a new class of broad-spectrum antiviral drugs.
Sex differences in the determination of prescribed load in ballistic bench press
Authors: Izadi Mohammad , Pillitteri Guglielmo , Thomas Ewan , Battaglia Giuseppe , Bianco Antonino , Bellafiore Marianna 
Published: January 2024

Introduction: The objectives of the present study were twofold: first, to identify the specific relative load at which the concentric motion transforms into a purely propulsive action among women, and second, to compare the load-velocity relationships between men and women during the bench press throw.Methods: Fourteen men and fourteen women participated in a test where they progressively increased the load until reaching their one-repetition maximum (1RM) in the bench press exercise. Linear regression models were employed to elucidate the relationships between load and velocity, as well as load and the propulsive phase (% of total concentric time). Additionally, ANCOVA was utilized to compare the linear regression models between men and women.Results: The results revealed strong and linear associations between load and mean propulsive velocity (MPV) for both men and women, as well as between load and the propulsive phase. Notably, there were significant differences in MPV and the propulsive phase concerning load between men and women. Women transitioned into a fully propulsive concentric phase at approximately 80% of their 1RM, while men achieved this entirely propulsive phase at around 85% of their 1RM. Furthermore, women exhibited reduced velocities when handling lighter relative loads compared to men. Conversely, women demonstrated higher velocities when dealing with loads exceeding 85% of their 1RM in contrast to their male counterparts.Discussion: These findings hold notable implications for prescribing bench press throw loads for women, which should differ from those recommended for men. Further studies are necessary to validate the efficacy of the proposed load recommendations.
Correlates of felt age in caregivers of people with dementia: findings from the IDEAL study
Authors: Sabatini Serena , Turner Shelbie G. , Morris Robin G. , Opdebeeck Carol , Thom Jeanette M. , Hunt Anna , Allan Louise , Pentecost Claire , Clare Linda 
Published: January 2024

ObjectiveFamily relationships influence how people appraise their own aging and how their appraisals impact their health. We analyzed felt age (FA) among family caregivers of people with dementia.Methods and measuresWe used a stratified sample of 1,020 spousal and 202 adult-child caregivers from the IDEAL study. We estimated cross-sectional associations and bidirectional influences between caregivers' FA and their health and wellbeing (depression, number of health conditions, stress, positive aspects of caregiving) over 2 years.ResultsAmong spousal caregivers, 25% had a younger FA and 36% had an older FA. Among adult-child caregivers, 21.8% had a younger FA and 36.1% had an older FA. In spousal and adult-child caregivers an older FA was cross-sectionally associated with higher depression, number of health conditions, and stress, and fewer positive aspects of caregiving. In spousal caregivers, hours of care per day moderated the association between FA and depression, and FA was associated with stress 1 year later.ConclusionCaregiving may impact FA and its relationship with health. We urge continued research on the connections between caregiving and FA, and how interventions might support caregivers' positive views on their own aging, which will translate views on aging scholarship to meaningfully improve caregivers' lives.
Dark triad personality traits are associated with decreased grey matter volumes in ‘social brain’ structures
Authors: Myznikov Artem , Korotkov Alexander , Zheltyakova Maya , Kiselev Vladimir , Masharipov Ruslan , Bursov Kirill , Yagmurov Orazmurad , Votinov Mikhail , Cherednichenko Denis , Didur Michael , Kireev Maxim 
Published: January 2024

IntroductionPersonality traits and the degree of their prominence determine various aspects of social interactions. Some of the most socially relevant traits constitute the Dark Triad – narcissism, psychopathy, and Machiavellianism – associated with antisocial behaviour, disregard for moral norms, and a tendency to manipulation. Sufficient data point at the existence of Dark Triad ‘profiles’ distinguished by trait prominence. Currently, neuroimaging studies have mainly concentrated on the neuroanatomy of individual dark traits, while the Dark Triad profile structure has been mostly overlooked.MethodsWe performed a clustering analysis of the Dirty Dozen Dark Triad questionnaire scores of 129 healthy subjects using the k-means method. The variance ratio criterion (VRC) was used to determine the optimal number of clusters for the current data. The two-sample t-test within the framework of voxel-based morphometry (VBM) was performed to test the hypothesised differences in grey matter volume (GMV) for the obtained groups.ResultsClustering analysis revealed 2 groups of subjects, both with low-to-mid and mid-to-high levels of Dark Triad traits prominence. A further VBM analysis of these groups showed that a higher level of Dark Triad traits may manifest itself in decreased grey matter volumes in the areas related to emotional regulation (the dorsolateral prefrontal cortex, the cingulate cortex), as well as those included in the reward system (the ventral striatum, the orbitofrontal cortex).DiscussionThe obtained results shed light on the neurobiological basis underlying social interactions associated with the Dark Triad and its profiles.
Testing a chain mediation model of effort-reward imbalance, Confucian values, job satisfaction, and intention to quit among Chinese vocational education teachers
Authors: Wang Guantao , Shi Jinyu 
Published: January 2024

ContextThis research delves into the significant impact of Confucian Values on the societal fabric of China, particularly in the realm of vocational education. In this setting, these principles are instrumental in guiding both educators and students. The study employs the Culture-Value Structure (CVS) model to dissect the intricate dynamics between Confucian Values, the Effort-Reward Imbalance (ERI), educators’ job satisfaction, and their inclination toward leaving the profession. Teachers in vocational education, who are often regarded as moral guides, play a pivotal role in the ethical and social upbringing of students. Adopting Confucian values not only promotes academic success but also nurtures all-round development, equipping students for conscientious societal roles. In the backdrop of Confucian influence, these educators face substantial stressors in the workplace due to varied demands. The ERI model, proposed by Siegrist, serves as a tool to comprehend the stress experienced when there is a disproportion between efforts and rewards. This study delves into how ERI correlates with job satisfaction among vocational education teachers, with a focus on the modifying effect of Confucian values. Additionally, it examines the potential role of job satisfaction in mediating the relationship between ERI and the tendency to consider leaving the job. The research illuminates the complex interrelation of cultural values, occupational stress, job contentment, and career decision-making in the context of vocational education in China.MethodologyThe research involved a group of 332 Vocational education teachers from diverse Chinese institutions. Through thorough statistical analysis, the study validated the model’s effectiveness, notably indicating a substantial direct impact of ERI on the Intention to Quit.FindingsThe investigation pinpointed Factors I (Integrity), II (Confucian Ethos), and IV (Moderation) as key determinants of job satisfaction. Notably, an increase in job satisfaction was found to inversely relate to the likelihood of leaving the profession, implying it could lessen the propensity to resign. The research applied a Chain Mediation Model to elucidate the influence of ERI on the decision to quit, mediated by various factors. The findings highlight the complex interaction of elements influencing teachers’ decisions to leave, showcasing the utility of sophisticated statistical methodologies in decoding complex social dynamics.
Challenges and coping experiences faced by nursing staff in long-term care facilities in China: a qualitative meta-analysis
Authors: Zhang Shibo , Xiao Xixi , Ai Yating , Zhang Ailin , Zhou Chunyi , Hu Hui , Wang Yuncui 
Published: January 2024

ObjectiveThe aim of this study is to discern the challenges and coping experiences encountered by nursing staff in long-term care facilities in China. This will be achieved through the identification, evaluation, and qualitative synthesis of comprehensive data.DesignThis is a qualitative meta-analysis.MethodsThe research systematically examined relevant literature sourced from six databases, concluding the search in August 2023. The inclusion criteria encompassed qualitative and mixed-methods studies in both Chinese and English, focusing on challenges faced by nursing staff in long-term care facilities and their corresponding coping strategies. The application of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework facilitated the qualitative meta-integration process. Three independent researchers meticulously screened and assessed the quality of the chosen studies. The synthesis process sought to amalgamate and structure analogous findings into novel categories through multiple readings of the original literature. These categories were subsequently distilled into comprehensive themes.ResultsAnalyzed 15 articles revealed 14 sub-themes and 4 overarching analytical themes. These encompassed Sources of Challenges such as multitasking, clinical emergencies, workplace conflict, demand exceeding resources, and occupational discrimination. Psychological impacts included suppressed emotion, compassion fatigue, and self-doubt. Practical consequences involved damaged health, imbalanced life, and occupational disappointment. Coping strategies identified were self-adjusting, feeling validation and belonging, and finding support.ConclusionOur research identified the challenges faced by nursing staff in Chinese long-term care facilities and their coping experiences. We found that most challenges could be mitigated through appropriate adjustments in managerial strategies, such as reasonable human resources planning, and providing resource support, including material, emotional, and informational support. Similarly, institutions should have offered necessary emotional and psychological support to nursing staff to overcome the negative impacts of challenges and encourage them to adopt positive coping strategies.
Indoor Air Quality and COVID-19: A Scoping Review
Authors: Braggion Axelle , Dugerdil Adeline , Wilson Olwen , Hovagemyan Francesca , Flahault Antoine 
Published: January 2024

Objectives: The COVID-19 pandemic has been a major public health concern for the past 3 years. Scientific evidence on the relationship between SARS-CoV-2 infection and indoor air quality still needs to be demonstrated. This scoping review aims to study the association between air quality indoors and COVID-19.Methods: A scoping review analyzing the association between indoor air quality and epidemiological outcomes was conducted. Papers published between 1 January 2020 and 31 October 2022 were included. Hospital settings were excluded from the study.Results: Eight relevant articles met the inclusion criteria. Indoor settings included workplaces, schools, restaurants, and public transport. Types of ventilation used to improve indoor air quality were dilution methods (opening windows) and mechanical systems with or without filtration or purifier. CO2 sensors were employed in one study. All the studies showed a positive association between indoor air quality and its improvement and epidemiological indicators.Conclusion: The findings of this scoping review indicate that indoor air quality, which can be improved with ventilation methods, may reduce the risk of developing COVID-19. Ventilation could thus be viewed as a possible effective mitigating method.