bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paolo Marzolo and Cesare Lombroso: a semiotic-medical inheritance between word, sounds, and face
Authors: Orrù Alice 
Published: October 2023

Abstract
Within the interdisciplinary context of the nineteenth century, the paper scrutinizes the relation between Paolo Marzolo’s theory of signs and Cesare Lombroso’s anthropological-criminal approach. Best known for his unfinished work Monumenti storici (1847–1866), Marzolo (of whom Lombroso calls himself a disciple) investigates, in his last Saggio sui segni (1866), the origin and development of languages by combining the positivist approach with an eighteenth-century encyclopedic Enlightenment perspective, as well as the earlier anatomist tradition. In his view, the human production, learning, and use of signs, resting upon sensory experiences and mnemonic activity, involves the process of imitation with a pivotal role of the speakers’ phonic, gestural, and facial expressions (i.e., physiognomy), related to geographical, linguistic, and anthropological differences among human individuals, as well as the cultural element of civilization. Conceived as case(s) of semiotic ideology rooted between linguistics and medicine, the Marzolo–Lombroso filiation shows an increasing correlation between race, language, and climate in the wake of social Darwinism and akin to other coeval physiognomic theories. In Lombroso’s perspective, a radical translation from a linguistic and phonic-semiotic field to an anthropological and somatic-semiotic plane seems inevitable, emphasizing the (para) scientific flavor and widening the gap between anthropometric and ethnoanthropological approaches.
Some properties of thermal insulating cement mortar using Ponza aggregate
Authors: Fattah Rania Amer , Al-Shathr Basil S. , Abed Suhair K. 
Published: October 2023

Abstract
Lightweight aggregate (LWA) mortar is made using lightweight or low-density aggregate, which improves properties such as thermal insulation, durability for freezing and thawing, fire and temperature resistance, and sound insulation. This research aims to use lightweight fine aggregate obtained from crushing natural rocks that are locally called “Ponza” to produce LWA mortar with different mix proportions to study the possibility of using it to produce blocks that can be erected on the outer side of the walls of old buildings to provide good thermal insulation. It also presents a study about the internal curing property of the produced cement mortar, which comes from the absorbed water by the used surface-saturated dry Ponza aggregate. The process includes using three mix proportions (1:1, 1:0.7, and 1:0.5) by weight of cement: fine aggregate. The samples were cured by dividing them into five groups, including moist curing for 1, 3, 7, and 28 days and the fifth group was moist cured for 1 day and then covered by a thin layer of flan coat. Dry density, compressive strength, flexural strength, and thermal conductivity for ages (7, 28, and 56 days) have been tested. The findings indicate that it is possible to produce thermal insulating lightweight cement mortar with mixtures of 1:0.7 or 1:0.5 cement to LWA, using Ponza aggregate, since the results showed an acceptable range of compressive and flexural strengths reaching about 14.75 and 2.91 MPa, respectively, a bulk density of less than 1,600 kg/mm3, and a lower thermal conductivity than many building materials.
Biosynthesis of zinc oxide nanoparticles from molted feathers of Pavo cristatus and their antibiofilm and anticancer activities
Authors: Ishwarya Ramachandran , Tamilmani Govindan , Al-Ghanim Khalid A. , Govindarajan Marimuthu , Nicoletti Marcello , Vaseeharan Baskaralingam 
Published: October 2023

Abstract
The present study employed molted feather ash extract from Pavo cristatus to synthesize zinc oxide nanoparticles (Pcf-ZnONPs). The Pcf-ZnONPs were characterized through advanced spectroscopy techniques to study the chemical and physical properties of NPs. Pcf-ZnONPs specifically exhibit an absorption peak at 365 nm in the UV spectroscopy analysis. TEM and SEM confirmed the nanoscale presence of ZnO. The antibiofilm and antibacterial properties of Pcf-ZnONPs were assessed against Staphylococcus aureus and Pseudomonas aeruginosa. At a concentration of 25 µg·mL−1, Pcf-ZnONPs exhibited a significant reduction in the thickness of bacterial biofilms. Breast cancer cell lines (MDA-MB-231) and fish cell lines were used to investigate in vitro anticancer activity. The MTT experiment demonstrated that Pcf-ZnONPs have good anticancer efficacy against a breast cancer and a fish cell line. The nontoxicity and biocompatibility of Pcf-ZnONPs were also investigated, exhibiting excellent hemocompatibility with red blood cells and no appreciable toxicity in Brine shrimp. In conclusion, Pcf-ZnONPs may be deemed nano-biomedicine compatible with biological systems for the treatment of bacterial illnesses in higher species.
A systematic review of the use of virtual reality in teaching Chinese as a foreign language
Authors: Liu Weiming 
Published: October 2023

Abstract
The purpose of this review is to provide a thorough analysis of existing research on the implementation of virtual reality (VR) in teaching Chinese as a foreign language (TCFL). In recent years, there has been a growing interest in the potential benefits of VR for language learning, and multiple studies have explored its application in TCFL. However, to date, no systematic reviews on the specific uses of VR in TCFL have been conducted. This study aims to bridge this gap by conducting a comprehensive review of empirical articles on the topic, identified from the Scopus and Web of Science databases. The search terms include “VR”, “virtual reality”, and “Chinese language”. The findings of this review shed light on the current trends in VR-related publications in the field of TCFL, the research settings where VR is used to support learning, and the potential benefits and effectiveness of VR in enhancing Chinese language learning, such as linguistic growth, communication skills, motivation, and immersive and authentic learning contexts. The review also highlights the challenges and limitations of using this technology in TCFL. The significance of this review lies in its potential to inform educators, researchers, and practitioners interested in using VR in TCFL about the current state of research and its implications for language learning. It can also contribute to the development of best practices for the effective use of VR in TCFL, ultimately leading to improved language learning outcomes for students.
CFD modeling of natural convection in pebble bed geometry with finite volume method
Authors: Said Çatalbas Salih , Tiftikci Ali 
Published: October 2023

Abstract
In this study, we used the finite volume method to computationally model natural convective flow in packed bed geometry. Using the OpenFOAM® v2112 code, we performed the computational analysis. We successfully meshed the intricate packed bed flow geometry, which consists of several spheres positioned at random. The spheres have sizes of 0.006 and 0.01 m, and the associated Rayleigh numbers are 1.83 × 107 and 8.48 × 107 respectively. We used the packed bed heights of H/d = 5, 10, and 20 in the simulations. By comparing the results of the OpenFOAM® v2112 simulations of the natural convection flow for all self-heating sphere in a packed bed, we demonstrated that the velocity distributions and Nusselt values are in good agreement with the experimental data. Additionally, it was evident from the velocity and temperature distributions in a packed bed core that there was a major temperature rise at nearby low velocity fields and a minor velocity rise in the intermediate and upper elevations. We showed that increasing the height of the pebble-bed core and correspondingly increasing the quantity of spheres inside it makes the flow more difficult and also generates local hot spots. This study is notable for using the finite volume method to evaluate natural convection flow in all self-heating packed beds and for simulating packed bed flow using a significant number of spheres. These two factors contribute to the originality of this work.
Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
Authors: You Yanjing , Wang Huijuan , Wang Qing , Yu Zongyang , Zhao Zhongquan , Zhuang Liying , Zeng Shengyuan , Zheng Jinyang , Wen Wen 
Published: October 2023

Abstract
Chronic obstructive pulmonary disease (COPD) is commonly caused by smoking. FUN14 domain-containing protein 1 (FUNDC1) plays a fundamental role in mitochondrial autophagy and apoptosis in cigarette smoke extract (CSE)-treated BEAS-2B cells. The present study investigated the mechanism of action of FUNDC1 in mitochondrial dysfunction and apoptosis in CSE-treated BEAS-2B cells. The interaction between ubiquitin-specific peptidase 19 (USP19) and FUNDC1 was analyzed using co-immunoprecipitation. Effects of USP19 knockdown and/or FUNDC1 overexpression on the survival, apoptosis, mitochondrial membrane potential, and oxygen consumption rate (OCR) of BEAS-2B cells treated with 15% CSE were determined. In BEAS-2B cells, CSE inhibited cell survival, promoted apoptosis, increased the expression of USP19 and FUNDC1, increased the ratio of LC3 II to LC3 I (LC3 II/I), and decreased mitochondrial membrane potential and TOM20 levels. In CSE-treated BEAS-2B cells, USP19 knockdown reduced FUNDC1 and LC3 II/I, increased the levels of TOM20, improved cell survival, mitochondrial membrane potential, and OCR, and inhibited apoptosis. USP19 deubiquitinates FUNDC1. FUNDC1 overexpression inhibited the effect of USP19 knockdown in CSE-treated BEAS-2B cells. Overall, decreasing USP19 expression alleviates CSE-induced mitochondrial dysfunction in BEAS-2B cells by downregulating FUNDC1, providing novel insights into the molecular mechanism of FUNDC1 regulation in COPD.
Das Überflüssige und die Überflüssigen
Authors: Dederich Markus , Zirfas Jörg 
Published: October 2023

Abstract
Diese Einleitung skizziert neben einigen begrifflichen Vorbemerkungen zwei Themenfelder, nämlich den Müll und eine Gruppe von Menschen, die in der Soziologie „die Überflüssigen“ genannt werden. Einerseits wird deutlich, dass der Müll die Rückseite der materiellen Kultur in ihrer Vielfältigkeit darstellt und dass die Geschichte der materiellen Kultur immer auch eine Geschichte dessen ist, was Menschen hinter sich lassen, wessen sie sich entledigen und was sie entsorgen. Andererseits macht die soziologische Ungleichheitsforschung deutlich, dass die „Überflüssigkeit“ von Menschen in einen Zusammenhang mit dem Problem der sozialen Exklusion und damit mit gezielter Ausgrenzung und funktionaler Ausschließung gebracht werden kann.
Überfluss und Überdruss in der Musik
Authors: Roch Eckhard 
Published: October 2023

Abstract
Musik ist eine Kunst des Maßes. Tonhöhe, Tondauer, Takt und Metrum, ferner Tempo und Lautstärke sind die messbaren musikalischen Parameter, die über- oder unterschritten werden können. Die Kategorie des Überflusses generiert in der Musik daher eine Reihe von Oppositionen wie: zu hoch/zu tief (Tonhöhe), zu laut/zu leise (Dynamik) usw. Ein dynamisches Ungleichgewicht entsteht, das zu Zwecken des musikalischen Ausdrucks nutzbar gemacht werden kann. Das Streben nach dynamischer Steigerung durch Überfluss ist ein typisches Merkmal romantischer Musik. Systemtheoretisch betrachtet bilden Produktion und Rezeption von Musik homöostatische Systeme aus, die durch Überfluss und/oder Mangel (Beschränkung) geregelt werden.
„Zu viel! Zu viel! O, daß ich nun erwachte!“
Richard Wagner, Tannhäuser, 1. Akt, 2. Szene.
Der Ausruf des Minnesängers Tannhäuser aus Richard Wagners gleichnamiger Oper könnte als ein Motto für Überfluss und Überdruss in der Musik des 19. und 20. Jahrhunderts bis hin zu unserer Gegenwart gelten. Zwar ist Überfluss keine musikalische Kategorie, aber die Phänomene des „Zu viel!“ oder des „Zu wenig!“ lassen sich bei ihr sehr wohl beobachten.
Salivary androgens in adolescence and their value as a marker of puberty: results from the SCAMP cohort
Authors: Patjamontri Supitcha , Spiers Alexander , Smith Rachel B , Shen Chen , Adaway Jo , Keevil Brian G , Toledano Mireille B , Faisal Ahmed S 
Published: October 2023

Context
Salivary androgens represent non-invasive biomarkers of puberty that may have utility in clinical and population studies.

Objective
To understand normal age-related variation in salivary sex steroids and demonstrate their correlation to pubertal development in young adolescents.

Design, setting and participants
School-based cohort study of 1495 adolescents at two time points for collecting saliva samples approximately 2 years apart.

Outcome measures
The saliva samples were analyzed for five androgens (testosterone, androstenedione (A4), 17-hydroxyprogesterone, 11-ketotestosterone and 11β-hydroxyandrostenedione) using liquid chromatography-mass spectrometry; in addition, salivary dehydroepiandrosterone (DHEA) and oestradiol (OE2) were analysed by ELISA. The pubertal staging was self-reported using the Pubertal Development Scale (PDS).

Results
In 1236 saliva samples from 903 boys aged between 11 and 16 years, salivary androgens except DHEA exhibited an increasing trend with an advancing age (ANOVA, P < 0.001), with salivary testosterone and A4 concentration showing the strongest correlation (r = 0.55, P < 0.001 and r = 0.48, P < 0.001, respectively). In a subgroup analysis of 155 and 63 saliva samples in boys and girls, respectively, morning salivary testosterone concentrations showed the highest correlation with composite PDS scores and voice-breaking category from PDS self-report in boys (r = 0.75, r = 0.67, respectively). In girls, salivary DHEA and OE2 had negligible correlations with age or composite PDS scores.

Conclusion
In boys aged 11–16 years, an increase in salivary testosterone and A4 is associated with self-reported pubertal progress and represents valid non-invasive biomarkers of puberty in boys.
In-silico study of the Effectiveness of Allium sativum L. extract as an Angiotensin-Converting Enzyme (ACE) Inhibitor in Hypertension
Authors: Limanto Agus , Husain Elma Eka Fitra , Dewajanti Anna Maria 
Published: October 2023

Over the last decade, the global prevalence of hypertension rate has increased by 5.2% and, in Indonesia, the prevalence rate has increased significantly from 25.8% in 2013 to 34.1% in 2018. Hypertension treatments using blood pressure-lowering drugs, such as angiotensin-converting enzyme (ACE) inhibitors, often cause unpleasant side effects. These side effects increase the interest in using potentially effective natural remedies, such as garlic. This study aimed to determine which organosulfur compounds in garlic can act as an ACE inhibitor to reduce blood pressure in hypertension using a cheminformatics approach. Eighteen organosulfur compounds of Allium sativum L. were screened based on Lipinski’s rules and ADMET evaluation. Seven compounds passed the screening and were subjected to QSAR analysis, molecular docking analysis, and molecular dynamics simulations to assess the stability of the protein. The seven compounds then underwent molecular docking and QSAR analysis. Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) and S-allylmercaptocysteine (SAMC) were two compounds with better docking values compared to the positive control compound. The QSAR analysis also showed that SAMC had an activity as an ACE inhibitor. The ADMET evaluation showed that Ajoene and SAMC had good absorption and could not penetrate the blood-brain barrier. Molecular dynamics simulation of ACE complexes Ajoene, SAMC, and Captopril ranged from 0.05 to 5.61 Å but exhibited a pattern of synonymous fluctuations for most residues. Based on the simulation data, the organosulfur compounds from garlic, Ajoene, and SAMC are proven to have a mechanism of action as ACE inhibitors to reduce blood pressure in hypertension.
Deus da “transcendência desviada"
Authors: Conde da Silva Alessandra F. , Machado dos Santos Thiago Gabriel 
Published: October 2023

Desde a sua publicação, em 1959, a Crônica da casa assassinada (2008), de Lúcio Cardoso, configura-se como a obra mais estudada do romancista. Muitos foram os críticos literários que demarcaram a importância desse romance na obra de Cardoso, tais como Álvaro Lins (1963), Alfredo Bosi (2015), Temístocles Linhares (1971), Massaud Moisés (2019) e Manuel Bandeira (1960). Além deles, Wilson Martins (1959) e André Seffrin (2008), em críticas realizadas sobre o romance, expõem o recuo dramático a que são sujeitas as personagens femininas centrais, Ana e Nina, no último capítulo da obra. No “Pós-escrito numa carta de Padre Justino”, o capítulo que arremata os acontecimentos na chácara dos Meneses, Ana confessa que André, reconhecido inicialmente como filho de Nina, é, na verdade, seu filho. Os críticos em questão compreendem o recurso dramático de Lúcio Cardoso, no capítulo final do romance, como um pedido de desculpas por abordar tema tão espinhoso quanto o incesto. Martins (1959) e Seffrin (2008) atribuem, também, lugar ao catolicismo do autor e ao moralismo e convencionalismo a que ele cedeu. Este artigo tem por objetivo, então, observar de que maneira o “Pós-escrito numa carta de Padre Justino”, diferentemente do que apontam os dois críticos, confere unidade à Crônica da casa assassinad quando lido a partir das orientações feitas em Mentira romântica e verdade romanesca (2009), de René Girard. Para tanto, analisa, de modo detido, a trajetória de Ana e Nina ao longo da narrativa e busca compreender, no pós-escrito, como as explicações obsequiadas na voz de Padre Justino gestam uma atmosfera menos conflitiva e maniqueísta no entendimento mimético dessas duas personagens.
Előzetes jelentés a röjtökmuzsaji nyakperec depóról
Authors: Mrenka Attila 
Published: October 2023

AbsztraktA tanulmány egy Röjtökmuzsajról előkerült, Magyarországon eddig egyedülálló leletegyüttest mutat be. Az Aunjetitz-kultúrára, ill. a körülötte lévő területekre jellemző nyakperec alakú fémöntvényeket tartalmazó kincsleletek szerepe ma még a közép- és nyugat-európai őskorkutatásban is viták tárgyát képezi, de jelenlétük fontos adatokkal szolgál a bronzkori fémművesség specializációjával és ezzel összefüggésben a központosított társadalom kérdéskörével kapcsolatban. A Röjtökmuzsaj-Tölgyerdőben napvilágot látott nyakperec öntvényeket tartalmazó raktárlelet (Ringbarrenhort) új megvilágításba helyezi az Északnyugat-Dunántúl kora és középső bronzkori történelmét a Kr. e. 2200–1500/1450 közötti időszakban.
Újabb preszkíta tőr a Dél-Dunántúlról
Authors: Szabó Géza , Gáti Csilla 
Published: October 2023

AbsztraktA jól ismert Pécs-Jakab-hegyi lelőhelytől mindössze 30 km-re, Dencsháza határában került elő egy újabb, Kabardino–Pjatigorszk-típusú, bimetál tőr. A sztyeppei kapcsolatokat mutató tőr a kaukázusi konfliktusövezetből, a Kr. e. 8. század végén menekülni kényszerülő lakossággal kerülhetett a Kárpát-medencébe.
How expected and experienced reward and relief contribute to gaming-related mental imagery and gaming frequency in daily life: Testing a dual pathway hypothesis
Authors: Brandtner Annika , Müller Silke M. , Brand Matthias 
Published: October 2023

AbstractBackground and aimsResearch on the development of gaming disorder assumes that the quality of reinforcement learning as well as the content of use expectancies are initially rewarding in the early stages of the addictive behavior and becomes steadily more compensatory in the later stages. This assumed transition could be reflected in gaming-related mental imagery as well as the decision to play videogames in daily life.MethodsWe recruited 127 individuals who play videogames. Following a strict diagnostic procedure, individuals were either classified as showing casual or at-risk gaming patterns. The experience and expectancy of reward and relief were assessed in the laboratory, followed by a 14-day ambulatory assessment asking for gaming-related mental imagery intensity and playing frequency. Besides group differences, we tested a gratification and a compensation pathway in a structural equation model among groups separately.ResultsResults indicate that mental imagery and playing frequency as well as reinforcement processes and use expectancies are heightened among individuals showing at-risk gaming patterns as compared to casual gaming patterns. Gaming-related mental imagery was only predicted by compensation among individuals showing casual gaming patterns, and we found no significant predictions for daily gaming frequency in any of the models.Discussion and conclusionsThe results implicate that individuals with at-risk gaming patterns might hold stronger learned reinforcement contingencies. Daily usage seems unaffected by these contingencies, possibly indicative of habitualized behaviors. Additionally, the results provide some support for the consideration of imaginal desire thoughts as a specific coping mechanism in the context of gaming behaviors.
Revocation of The Attachment III of The Presidential Regulation Number 10 of 2021 in The Perspective of Human Rights and Maqasid Al-Shari‘ah
Authors: Sanuri Sanuri 
Published: October 2023

This research is based on a decision of the President of the Republic of Indonesia, Joko Widodo, by revoking the Attachment III of the Presidential Regulation Number 10 of 2021 concerning the business sector of investment in the liquor and alcoholic drink industry. This presidential decree attracts a wide attention from all levels of Indonesian society. Most of them welcome the decision, and a few are more optimistic about the implementation of the presidential regulation because it has actually offered a clear and proportional regulation. To get a sharp analysis result, the researcher looks at this constitutional fact through the theory of human rights and maqasid al-shari’ah. Based on the research results, it is stated that the decision of the President of the Republic of Indonesia by abolishing the presidential regulation is in line with the basic values ​​and principles contained in human rights and maqasid al-shari’ah. Even so, there are some basic rights points that need serious attention from the government, particularly how to revive the people’s economy which is teetering due to the Covid-19 pandemic. At least, this is the reason for arguing for groups who are oppossing to the presidential decision.

Abstrak: Penelitian ini bertumpu pada sebuah keputusan Presiden Republik Indonesia, Joko Widodo, dengan mencabut Lampiran III Peraturan Presiden Nomor 10 Tahun 2021 tentang bidang usaha penanaman modal dan investasi industri minuman keras dan minuman beralkohol. Keputusan presiden ini cukup mengundang perhatian dari seluruh lapisan masyarakat Indonesia. Sebagian besar dari mereka menyambut gembira keputusan itu, dan sebagian kecil lebih optimis dengan pemberlakuan peraturan presiden itu karena sebenarnya telah menawarkan suatu regulasi yang jelas dan proporsional. Untuk mendapatkan hasil analisis yang tajam, peneliti melihat fakta konstitusi ini melalui teori Hak Asasi Manusia dan maqasid al-shari’ah. Berdasarkan hasil penelitian menyatakan bahwa keputusan yang diambil Presiden Republik Indonesia dengan menghapus peraturan presiden itu sejalan dengan nilai-nilai dan prinsip-prinsip dasar yang tertuang dalam hak asasi manusia dan maqasid al-shari’ah. Meskipun demikian, ada beberapa poin hak-hak dasar yang perlu mendapatkan perhatian serius dari pemerintah terutama bagaimana membangkitkan perekonomian rakyat yang tertatih-tatih akibat pandemic Covid-19. Setidaknya, inilah yang menjadi alasan mendasar kelompok yang berseberangan dengan keputusan presiden tersebut.