bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age has a U-shaped relationship with breast cancer outcomes in women: a cohort study
Authors: Xie Yujie , Deng Yongqing , Wei Suosu , Huang Zhen , Li Lihui , Huang Kai , Wei Chunyu , Xu Jinan , Dong Lingguang , Zhang Qiuhuan , Zhao Jiehua , Zou Quanqing , Yang Jianrong 
Published: October 2023

Background and ObjectivesAge is a significant determinant of susceptibility to breast cancer. Currently, the available evidence regarding the non-linear correlation between the age of diagnosis and the prognosis of breast cancer patients is contradictory. Insufficient data currently exist regarding the influence of age at diagnosis on the prognosis of breast cancer. The objective of our investigation was to examine the relationship between age at diagnosis and overall survival (OS), breast cancer-specific survival (BCSS), and disease-free survival (DFS).MethodsThis retrospective cohort study included 1054 patients diagnosed with breast cancer between March 7, 2013 and December 31, 2019. The hazard ratios (HRs) and 95% confidence interval (CI) for OS, BCSS, DFS were assessed using Cox proportional hazard ratio models and restricted cubic splines (RCS).ResultsThe study included 1054 breast cancer patients who met the criteria. With a median follow-up of 4.86 years, 71 patients (6.74%) died and 144 patients (13.66%) relapsed. After multivariable adjustment, age showed a U-shaped association with OS, BCSS, and DFS, with significantly higher risk at two ends, with age inflection points of 44, 44, and 41 years for OS, BCSS, and DFS, respectively. For OS, Quartile 1 (HR, 2.09; 95% CI: 0.90-4.84), Quartile 3 (HR, 2.44; 95% CI: 1.05-5.65) and Quartile 4 (HR, 3.38; 95% CI: 1.51-7.54) had poorer OS compared with Quartile 2. Similar results were found for BCSS and DFS.ConclusionsThis study confirmed a U-shaped association between age at diagnosis and breast cancer outcome.
Emotional behavioral outcomes of children with unilateral and mild hearing loss
Authors: Ong Jun Jean , Smith Libby , Shepherd Daisy A. , Xu Jessica , Roberts Gehan , Sung Valerie 
Published: October 2023

BackgroundDeaf and hard-of hearing (DHH) children often experience emotional/behavioral difficulties. The impact of unilateral/mild hearing loss (HL) on children's emotion and behavior are unclear. We aimed to describe emotional/behavioral, health related quality-of-life (HRQoL) and parent psychological distress outcomes of school-age children with unilateral/mild HL, compared to children with moderate to profound HL, and in relation to population norms; and identify predictive factors of emotional/behavioral difficulties.MethodsData of 339 DHH children, 5–12 years, enrolled in the Victorian Childhood Hearing Longitudinal Databank (VicCHILD), which include demographics, early development, medical/audiological characteristics and parent rated questionnaires of emotion/behavior, HRQoL and parental psychological distress collected at various stages of child's life were analyzed. We used Cohen's d to investigate the outcomes by measuring the mean score differences of both groups with published norms and logistic regression to analyze the factors predictive of emotional/behavioral difficulties.ResultsThe proportion of children with unilateral/mild HL and moderate to profound HL who experienced emotional/behavioral difficulties was similar (18.3% vs. 20.6%), with hyperactivity and poor prosocial behavior reported as the predominant symptoms in both groups. Mean emotional/behavioral scores of both groups were comparable and substantially higher than normative population scores. This was also the case for HRQoL and levels of parent distress. Among children with unilateral/mild HL, additional health needs were the strongest predictive factor, demonstrating an approximately 1.7-fold increase in odds of emotional/behavioral difficulties (OR = 1.67; 95% CI 1.29–2.17,p &lt; 0.001) with every additional health need. Early developmental concerns, other than communication milestone and attending mainstream schoolshowed weaker evidence of association.ConclusionChildren with unilateral/mild HL were just as likely as those with moderate to profound HL to experience more emotional/behavioral difficulties, poorer HRQoL and higher parental distress scores compared to population norms. Our findings justify the provision of early intervention, support and medical services for all DHH children to identify those at risk of poorer outcomes.
The effect of tacrolimus conversion from immediate- to extended-release formulation on renal function in renal transplant patients: a meta-analysis
Authors: Chao Sheng , Jia Lei , Zhu Kejing , Chen Luobei , Niu Yulin 
Published: October 2023

Objective: Tacrolimus formulation affects the outcomes of a renal transplant, while the effect of its immediate- to extended-release conversion remains controversial. This meta-analysis aimed to compare the renal function before and after tacrolimus immediate- to extended-release conversion in renal transplant patients.Methods: PubMed, Cochrane, Embase, CNKI, CQVIP, and Wanfang databases were searched for articles regarding the effect of tacrolimus conversion from immediate- to extended-release formulation on renal function in renal transplant patients. The data on serum creatinine (Scr) or the estimated glomerular filtration rate (eGFR) before and after conversion were extracted and analyzed.Results: Ten studies with 743 renal transplant patients were included. Scr was reduced after conversion versus before conversion [mean difference (MD) (95% confidence interval (CI)): -8.00 (−14.33; −1.66) μmol/L, p = 0.01]. However, eGFR only showed an increased trend after conversion versus before conversion (MD (95% CI): 2.21 (−1.62, 6.03) mL/min/1.73 m2, p = 0.26) but without statistical significance. Furthermore, in patients with a follow-up duration ≥48 weeks, Scr was decreased after conversion versus before conversion (p = 0.005), but eGFR remained unchanged (p = 0.68). However, in patients with a follow-up duration &lt;48 weeks, both Scr (p = 0.36) and eGFR (p = 0.24) were not different before conversion versus after conversion. Moreover, publication bias risk was low, and robustness assessed by sensitivity analysis was generally good.Conclusion: This meta-analysis favors studies indicating that the conversion of tacrolimus from an immediate-release to an extended-release formulation could improve the kidney function to some extent in renal transplant patients, and this advancement may be related to the administration period.
Key elements in the quality assessment of a type 3 medication review
Authors: Robberechts Anneleen , Michielsen Melissa , Steurbaut Stephane , De Meyer Guido R. Y. , De Loof Hans 
Published: October 2023

Background: Medication reviews are a structured evaluation of a patient’s pharmacotherapy with the aim of optimizing medicines use and improving health outcomes. This entails detecting drug related problems and recommending interventions. A high level of quality is essential for the successful implementation of this service in community pharmacies but currently there is no instrument or tool to assess that overall quality.Aim: This study investigated the development of quality criteria of type 3 medication reviews (MR3s).Methods: After surveying the literature, an electronic questionnaire was developed to gather information about quality criteria for MR3. This survey, in Dutch, was distributed electronically. Four groups were queried: 1) pharmacists, mainly working in the Netherlands, involved in practice research and contacted through the PRISMA (Practice Research In Collaboration With Pharmacists) foundation, 2) Belgian pharmacy academics and pharmacists active in professional associations (APA), 3) Belgian pharmacists trained in medication review (MR) by the Royal Pharmacists Association of Antwerp (KAVA) and 4) Belgian pharmacy students. The survey included 57 criteria, divided into eight domains, which were ranked according to their importance by the participants. The results were analyzed statistically using the nonparametric Kruskal–Wallis test.Results: The survey was completed by 95 participants, including 42 PRISMA pharmacists, 19 APA pharmacists, 18 KAVA pharmacists and 16 pharmacy students. Opinions from participants from the different groups overlapped significantly. The use of simple and understandable language in the conversation with the patient was considered essential by the majority. Discussing the usefulness and purpose of a MR3 with the patient was also rated highly by all groups. Differences of opinion were present in aspects about laboratory values, the use of specific tools, and reporting to and consultation with the treating physician. The participants themselves formulated a limited number of additional assessment criteria.Conclusion: There was widespread agreement on the hierarchy of the quality assessment criteria for MR3s. Minor differences were related to the experience of the participants. With these results and a small number of suggested extra criteria, a quality assessment instrument for MR3 can be created.
Understanding how high stocking densities and concurrent limited oxygen availability drive social cohesion and adaptive features in regulatory growth, antioxidant defense and lipid metabolism in farmed gilthead sea bream (Sparus aurata)
Authors: Holhorea Paul G. , Naya-Català Fernando , Belenguer Álvaro , Calduch-Giner Josep A. , Pérez-Sánchez Jaume 
Published: October 2023

The study combined the use of biometric, behavioral, physiological and external tissue damage scoring systems to better understand how high stocking densities drive schooling behavior and other adaptive features during the finishing growing phase of farmed gilthead sea bream in the Western Mediterranean. Fish were grown at three different final stocking densities (LD, 8.5 kg/m3; MD, 17 kg/m3; HD, 25 kg/m3). Water oxygen concentration varied between 5 and 6 ppm in LD fish to 3–4 ppm in HD fish with the summer rise of water temperature from 19°C to 26°C (May–July). HD fish showed a reduction of feed intake and growth rates, but they also showed a reinforced social cohesion with a well-defined endogenous swimming activity rhythm with feeding time as a main synchronization factor. The monitored decrease of the breathing/swimming activity ratio by means of the AEFishBIT data-logger also indicated a decreased energy partitioning for growth in the HD environment with a limited oxygen availability. Plasma glucose and cortisol levels increased with the rise of stocking density, and the close association of glycaemia with the expression level of antioxidant enzymes (mn-sod, gpx4, prdx5) in liver and molecular chaperones (grp170, grp75) in skeletal muscle highlighted the involvement of glucose in redox processes via rerouting in the pentose-phosphate-pathway. Other adaptive features included the depletion of oxidative metabolism that favored lipid storage rather than fatty acid oxidation to decrease the oxygen demand as last electron acceptor in the mitochondrial respiratory chain. This was coincident with the metabolic readjustment of the Gh/Igf endocrine-growth cascade that promoted the regulation of muscle growth at the local level rather than a systemic action via the liver Gh/Igf axis. Moreover, correlation analyses within HD fish displayed negative correlations of hepatic transcripts of igf1 and igf2 with the data-logger measurements of activity and respiration, whereas the opposite was found for muscle igf2, ghr1 and ghr2. This was indicative of a growth-regulatory transition that supported a proactive instead of a reactive behavior in HD fish, which was considered adaptive to preserve an active and synchronized feeding behavior with a minimized risk of oxidative stress and epidermal skin damage.
A fast Fourier convolutional deep neural network for accurate and explainable discrimination of wheat yellow rust and nitrogen deficiency from Sentinel-2 time series data
Authors: Shi Yue , Han Liangxiu , González-Moreno Pablo , Dancey Darren , Huang Wenjiang , Zhang Zhiqiang , Liu Yuanyuan , Huang Mengning , Miao Hong , Dai Min 
Published: October 2023

IntroductionAccurate and timely detection of plant stress is essential for yield protection, allowing better-targeted intervention strategies. Recent advances in remote sensing and deep learning have shown great potential for rapid non-invasive detection of plant stress in a fully automated and reproducible manner. However, the existing models always face several challenges: 1) computational inefficiency and the misclassifications between the different stresses with similar symptoms; and 2) the poor interpretability of the host-stress interaction.MethodsIn this work, we propose a novel fast Fourier Convolutional Neural Network (FFDNN) for accurate and explainable detection of two plant stresses with similar symptoms (i.e. Wheat Yellow Rust And Nitrogen Deficiency). Specifically, unlike the existing CNN models, the main components of the proposed model include: 1) a fast Fourier convolutional block, a newly fast Fourier transformation kernel as the basic perception unit, to substitute the traditional convolutional kernel to capture both local and global responses to plant stress in various time-scale and improve computing efficiency with reduced learning parameters in Fourier domain; 2) Capsule Feature Encoder to encapsulate the extracted features into a series of vector features to represent part-to-whole relationship with the hierarchical structure of the host-stress interactions of the specific stress. In addition, in order to alleviate over-fitting, a photochemical vegetation indices-based filter is placed as pre-processing operator to remove the non-photochemical noises from the input Sentinel-2 time series.Results and discussionThe proposed model has been evaluated with ground truth data under both controlled and natural conditions. The results demonstrate that the high-level vector features interpret the influence of the host-stress interaction/response and the proposed model achieves competitive advantages in the detection and discrimination of yellow rust and nitrogen deficiency on Sentinel-2 time series in terms of classification accuracy, robustness, and generalization.
Buy solar, get cashback: do consumer subsidies described as promotions influence electricity choices?
Authors: Kühne Swen J. , Reijnen Ester 
Published: October 2023

IntroductionMost countries want to make the transition to increased or even exclusive use of renewable energy. To achieve this goal, how can individuals be persuaded to use more renewable electricity? For example, does the way energy companies communicate so-called consumer subsidies matter in this regard, and if so, which communication strategy is best? For example, is a monetary promotion (e.g., cashback) better than a non-monetary one (e.g., gift)?MethodsIn a total of four studies (with a total of more than 1700 participants), we investigated what type of promotion most influenced the choice of a renewable energy product, varying, for example, the environmental friendliness of the renewable energy product.ResultsThe monetary promotion (e.g., get $35 back through subsidies) appeared to be the most successful; it significantly increased the choice of the renewable electricity product (i.e., between 12–22%). However, this result was only evident when the subsidized renewable product was not the product already preferred by most individuals. Other measures, such as the willingness to pay (WTP), showed no differential effects.DiscussionOverall, the observed pattern suggests that promoting renewable energy choices, is similar to promoting donations to a charity. Accordingly, the description of the consumer subsidy as a monetary promotion (i.e., cashback or negative labeling) is most effective in terms of promotion. However, the effect of monetary promotions seems to diminish if the subsidized product is already the product preferred by most consumers. Nevertheless, the use of monetary promotions can encourage the transition to renewable energy.
Optimizing intervention components for sleep promotion in children in the context of obesity prevention: the SLEEPY 2.0 study protocol
Authors: Fair Maddy , Decker Jessica , Fiks Alexander G. , Mayne Stephanie , Morales Knashawn H. , Williamson Ariel A. , Mitchell Jonathan A. 
Published: October 2023

BackgroundInsufficient sleep duration is highly prevalent in childhood and is associated with obesity, especially among middle school-aged children. The primary care setting has enormous potential to promote sleep, but limited time and sleep resources at in person appointments are key barriers. Digital health innovations offer solutions to these barriers. Mobile health platforms can be developed to deliver behavioral sleep promotion remotely in the home setting, with tailoring to individual and contextual factors to help ensure equitable effectiveness across sociodemographic groups. This paper presents the protocol for a randomized optimization trial using the Multiphase Optimization Strategy (MOST) to develop a mobile health platform for the pediatric care setting to promote longer sleep duration for childhood obesity prevention.MethodsThis is a single-site study being conducted at the Children's Hospital of Philadelphia. We will randomize 325 children, aged 8–12 y, with a body mass index (BMI) between the 50th−95th percentile, and who sleep &lt;8.5 h per night. The Way to Health mobile platform will facilitate remote communication and data collection. A sleep tracker will estimate sleep patterns for 12-months (2-week run-in; 6-month intervention; ≈5.5-month follow-up). A randomized 24 factorial design will assess four components: sleep goal (≥9 h or ≥30 min above baseline sleep duration), digital guidance (active or active with virtual study visits), caregiver incentive (inactive or active), and performance feedback (inactive or active). Fat mass will be measured at baseline, 6-, and 12-months using dual energy X-ray absorptiometry. Total energy intake and the timing and composition of meals will be measured using 24-h dietary recalls at baseline, 6-, and 12-months. Sociodemographic data (e.g., sex, race, ethnicity) will be measured using self-report and home addresses will be geocoded for geospatial analyses.DiscussionWe anticipate that this innovative optimization trial will identify optimal component settings for sleep promotion in children, with clinically meaningful improvements in fat mass trajectories. Importantly, the platform will have broad impact by promoting sleep health equity across sociodemographic groups. With the optimal settings identified, we will be able to determine the effectiveness of the final intervention package under the evaluation phase of the MOST framework in a future randomized controlled trial. Our proposed research will greatly advance the field of behavioral sleep medicine and reimagine how insufficient sleep duration and obesity are prevented in pediatric healthcare.Trial registrationClinicalTrials.gov NCT05703347 registered on 30 January 2023.
Present results and future effects of internationalization in the agro-food sector of countries with a planned economy
Authors: Mihăilescu Ioan , Wirsig Hermann 
Published: October 2023

The internationalization process produces its effects on the different branches of the agro-food sector ;
• In upstream and downstream industries, concentration of production units, modernization of technologies, specialization and standardization of products.
• In the relationships between agriculture and industry, development of vertical integration, substitution of food product markets for agricultural product markets.
• In agriculture itself, restructuring of production, specialization concentration of production units, industrialization, increasing complexity of the agricultural organization, standardization of the production conditions.
Moreover, the internationalization of production and exchange conditions in the agro-food sector changes the relationships between the national economies as a whole .
Evolution des prix alimentaires et structures de marché
Authors: Allaya Mahmoud , Ghersi Gérard , Padilla Martine 
Published: October 2023

Cet article analyse l'évolution des structures du marché des produits alimentaires en France d'après le pouvoir quantitatif des firmes concernées pour la période 1970-1979.
Cette évolution a été caractérisée principalement par une diminution du pouvoir de la structure concurrentielle, particulièrement pour la confiserie, l'industrie du lait, les liqueurs et bières.
Cette analyse se poursuit par l'examen de l'évolution des prix de détail pour mesurer ensuite les conséquences de la transformation des structures de marché sur les changements de prix.
Méso-analyse et économie agroalimentaire
Authors: Lauret Frédéric , Pérez Roland 
Published: October 2023

Le présent essai vise à apporter une contribution à une approche méso-analytique de l'agroalimentaire.
Après avoir rappelé les fondements et les exigences de la méso-analyse, les auteurs montrent que l'économie agroalimentaire constitue, à travers ses différentes composantes, un terrain privilégié pour cette approche : évolution des filières, émergence des groupes et des structures oligopolistiques, mise en question du rapport à l'espace.
Ils plaident ensuite pour une méso-économie agroalimentaire, dont ils montrent la nécessité et l actualité, et pour laquelle ils proposent quelques éléments d’un programme de recherches.
Sistemas de información con metodología SCRUM para la gestión de proyectos de investigación en ingeniería de sistemas por ciclos propedeúticos
Authors: Cardoso Luis Antonio Herrán , Arana Jorge Leonardo Castro , Ramirez Mauren Andres Guayara 
Published: October 2023

En el Instituto Tolimense de Formación Técnica Profesional ITFIP ubicada en el Espinal Tolima Colombia, se cuenta con el programa de Ingeniería de Sistemas por Ciclos Propedéuticos. La presente investigación muestra los avances en la investigación acerca del Desarrollo de un Sistema de gestion de la información en proyectos de semilleros de investigación, donde se evidencia la estructura lógica de programación en PHP y de diseño de base de datos con MYSQL, así como la aplicación de la metodología SCRUM lo que evidencia sus ventajas para el trabajo en equipo y el diseño modular del software. De esta manera, se logra optimizar el control de la información presentada por los estudiantes creando un repositorio de proyectos de impacto en la región del centro de Colombia, bajo la línea de investigación de Desarrollo de software en los tres niveles de formación, Técnico Profesional, Tecnología y profesional en Ingeniería de Sistema.