bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing seasonally variable photosynthetic parameters based on joint carbon and water flux constraints
Authors: Leng Jiye , Chen Jing M. , Li Wenyu , Luo Xiangzhong , Rogers Cheryl , Croft Holly , Xie Xinyao , Staebler Ralf M. 
Published: January 2024

Abstract

Terrestrial biosphere models (TBMs) often adopt the Farquhar biochemical model coupled with the Ball-Berry stomatal conductance (\({g}_{s}\)) model to simulate ecosystem carbon and water fluxes. The parameters \(m\), representing the sensitivity of \({g}_{s}\) to the photosynthetic rate, and \({V}_{cmax}^{25}\), representing the leaf photosynthetic capacity, are two pivotal parameters but the two main sources of uncertainties in TBM simulations. The spatial and temporal variations of \(m\) in TBMs are still elusive, due to the lack of direct observations. It also remains unclear how accurate estimates of \(m\) and \({V}_{cmax}^{25}\) can improve the simulations of carbon and water fluxes. In this study, we used a Bayesian parameter optimization approach to infer seasonally varying \(m\) and \({V}_{cmax}^{25}\) from eddy covariance observations in a mixed forest stand at the Borden Forest Research Station located in southern Ontario, Canada, and used in-situ observations of \(m\) and \({V}_{cmax}^{25}\) for validation. Three strategies were tested for optimizing \(m\) and \({V}_{cmax}^{25}\), including the carbon, water, and carbon-water coupling scenarios. \(m\) and \({V}_{cmax}^{25}\) optimized from carbon-water coupling constraints shows best correlations with the measured \(m\) (R2 = 0.70) and \({V}_{cmax}^{25}\) (R2 = 0.70). By incorporating optimized \(m\) and \({V}_{cmax}^{25}\)with seasonal variations, we found considerable improvements in the estimated gross primary productivity (GPP) and evapotranspiration (ET) compared with constant \(m\) and \({V}_{cmax}^{25}\), with R2 increasing from 0.78 to 0.85 for GPP, from 0.65 to 0.71 for ET and RMSE reducing from 2.579 g C m− 2 d− 1 to 2.038 g C m− 2 d− 1 for GPP, from 1.151 mm d− 1 to 0.137 mm d− 1 for ET. This study proposes an effective approach to retrieve \(m\) and \({V}_{cmax}^{25}\) for TBMs and demonstrates the efficacy of incorporating seasonally variable \(m\) and \({V}_{cmax}^{25}\) for reducing the uncertainties in GPP and ET simulations, which supports accurate quantifications of land-atmosphere exchanges.
INOVAÇÕES TECNOLÓGICAS E OS SEUS IMPACTOS NA TRANSFORMAÇÃO DO GOVERNO DIGITAL
Authors: Oliveira Gomes Hermes , Camargo Maria Emília 
Published: January 2024

Muitas organizações públicas e privadas estão cada vez mais sendo desafiadas a implementar soluções tecnológicas em suas rotinas operacionais, muitas recentemente pela influência de fatores externos como foi a caso da covid-19, outras a fim de modernizar seus processos e serviços internos com soluções mais eficientes para o usuário. Neste sentido, em muitos países, governos têm implementado processos de transformações tecnológicas e digitais a fim de modernizar e dinamizar a prestação de serviços para com os cidadãos, buscando redução de custo e melhoria na eficiência dos serviços. Essa pesquisa visa identificar as ferramentas de transformação digital e seus impactos nas iniciativas de políticas públicas do governo digital. Para isso, usa-se uma técnica de mapeamento sistemático de revisão de literatura. Como resultado, constata-se que as pesquisas sobre governo digital vêm crescendo ao longo do tempo, sendo mais recorrente a publicação de artigo em revistas especializadas, como é o caso da Government Information Quarterly, IEEE Access, Digital Government: Research and Practice, entre outros. Entre as principais tecnologias usadas, destaca o Big Data, Inteligência Artificial, Internet das Coisas, assim por diante. Já relacionado às pessoas, o trabalho identificou que a falta de conhecimento das pessoas e a falta de recursos são uns dos principais entraves na implementação das políticas públicas do governo digital.
Potential Impact of Bioactive Compounds as NLRP3 Inflammasome
Inhibitors: An Update
Authors: Singh Sonia , Sharma Shiwangi , Sharma Himanshu 
Published: January 2024

Abstract:
The inflammasome NLRP3 comprises a caspase recruitment domain, a pyrin domain
containing receptor 3, an apoptosis-linked protein like a speck containing a procaspase-1, and an
attached nucleotide domain leucine abundant repeat. There are a wide variety of stimuli that can
activate the inflammasome NLRP3. When activated, the protein NLRP3 appoints the adapter
protein ASC. Adapter ASC protein then recruits the procaspase-1 protein, which causes the procaspase-
1 protein to be cleaved and activated, which induces cytokines. At the same time, abnormal
activation of inflammasome NLRP3 is associated with many diseases, such as diabetes,
atherosclerosis, metabolic syndrome, cardiovascular and neurodegenerative diseases. As a result,
a significant amount of effort has been put into comprehending the mechanisms behind its
activation and looking for their specific inhibitors. In this review, we primarily focused on phytochemicals
that inhibit the inflammasome NLRP3, as well as discuss the defects caused by
NLRP3 signaling. We conducted an in-depth research review by searching for relevant articles
in the Scopus, Google Scholar, and PubMed databases. By gathering information on phytochemical
inhibitors that block NLRP3 inflammasome activation, a complicated balance between inflammasome
activation or inhibition with NLRP3 as a key role was revealed in NLRP3-driven
clinical situations.
Therapeutic Potential of Capsaicin in Various Neurodegenerative Diseases
with Special Focus on Nrf2 Signaling
Authors: Varshney Vibhav , Kumar Abhishek , Parashar Vikas , Kumar Ankit , Goyal Ahsas , Garabadu Debapriya 
Published: January 2024

abstract:
Neurodegenerative disease is mainly characterized by the accumulation of misfolded
proteins, contributing to mitochondrial impairments, increased production of proinflammatory
cytokines and reactive oxygen species, and neuroinflammation resulting in synaptic loss and
neuronal loss. These pathophysiological factors are a serious concern in the treatment of neurodegenerative
diseases. Based on the symptoms of various neurodegenerative diseases, different
treatments are available, but they have serious side effects and fail in clinical trials, too. Therefore,
treatments for neurodegenerative diseases are still a challenge at present. Thus, it is important
to study an alternative option. Capsaicin is a naturally occurring alkaloid found in capsicum.
Besides the TRPV1 receptor activator in nociception, capsaicin showed a protective effect
in brain-related disorders. Capsaicin also reduces the aggregation of misfolded proteins, improves
mitochondrial function, and decreases ROS generation. Its antioxidant role is due to increased
expression of an nrf2-mediated signaling pathway. Nrf2 is a nuclear erythroid 2-related
factor, a transcription factor, which has a crucial role in maintaining the normal function of mitochondria
and the cellular defense system against oxidative stress. Intriguingly, Nrf2 mediated
pathway improved the upregulation of antioxidant genes and inhibition of microglial-induced
inflammation, improved mitochondrial resilience and functions, leading to decreased ROS in
neurodegenerative conditions, suggesting that Nrf2 activation could be a better therapeutic approach
to target pathophysiology of neurodegenerative disease. Therefore, the present review
has evaluated the potential role of capsaicin as a pharmacological agent for the treatment and
management of various neurodegenerative diseases via the Nrf2-mediated signaling pathway.
An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides
Authors: Sivaraman Sachithanantham Annapoorani , Sabareesh Varatharajan 
Published: January 2024

Abstract:
Diabetes is a chronic metabolic disorder. According to the International Diabetes Federation,
about 537 million people are living with diabetes. The two types of diabetes are type 1 diabetes
mellitus (T1DM) and type 2 diabetes mellitus (T2DM), among which the population affected by
T2DM is relatively higher. A major reason for T2DM is that insulin stimulation is hampered due to
the inactivation of incretin hormones. Dipeptidyl peptidase-IV (DPP-IV) is a serine protease that is
directly involved in the inactivation of incretin hormones, e.g., glucagon-like peptide-1 (GLP-1).
Therefore, the inhibition of DPP-IV can be a promising method for managing T2DM, in addition to
other enzyme inhibition strategies, such as inhibition of α-amylase and α-glucosidase. Currently,
about 12 different gliptin drugs are available in the market that inhibit DPP-IV in a dose-dependent
manner. Instead of gliptins, ‘peptides’ can also be employed as an alternative and promising way to
inhibit DPP-IV. Peptide inhibitors of DPP-IV have been identified from various plants and animals.
Chemically synthesized peptides have also been experimented for inhibiting DPP-IV. Most peptides
have been analysed by biochemical assays, whereas some in vitro assays have also been reported.
Molecular docking analysis has been applied to comprehend the mechanism of inhibition. In this
review, certain aspects of natural as well as synthetic peptides are described that have been proven
to inhibit DPP-IV.
Pulmonary Arterial Hypertension (PAH) Group 1 (Part A): Overview,
Classification, Clinical Subsets, and Workup
Authors: Yaqoob Maidah , DeCato Thomas W. , Oudiz Ronald 
Published: January 2024

Abstract:
Pulmonary hypertension is a rare, progressive disease characterized by increased pulmonary
arterial pressure and right ventricular failure due to pulmonary vascular remodeling. The
disease definition and management have evolved over time. The 6th WSPH now defines it as a
mean pulmonary arterial pressure >20mmHg, while recent ESC/ERS guidelines recommend lowering
the threshold for pulmonary vascular resistance to 2WU.

:
Understanding of the disease has improved through registries, classifying it into five distinct
groups with similar histology, pathophysiology, and therapeutic approaches. These groups include
PAH, with heritable and idiopathic causes, as well as various clinical subsets involving connective
tissue disease, HIV, portopulmonary hypertension, congenital heart disease, and schistosomiasis.
Long-term responders to calcium channel blockers, PAH with venous/capillaries involvement,
and persistent PH of newborns are categorized under Group 1, now re-classified as IPAH.

:
A comprehensive workup for suspected patients includes various tests like electrocardiogram, pulmonary
function testing, autoimmune workup, HIV testing, echocardiogram, right heart catheterization,
and cardiopulmonary exercise testing.

:
This review emphasizes the disease's definition and epidemiology, delving into each subset and
providing updated workup guidelines. The subsequent article will focus on risk stratification and
treatment strategies.
Exploring the Therapeutic Marvels: A Comprehensive Review on the
Biological Potential of Quinoline-5,8-Dione
Authors: Agrawal Neetu , Bansal Dimple , Pathak Shilpi 
Published: January 2024

Abstract:
Quinoline-5,8-diones, also referred to as 5,8-quinolinediones or quinolinequinones, have
been researched extensively for their antiproliferative effects, where they displayed great results.
Other than anticancer, they exhibit multiple activities such as antimalarial, antiviral, antibacterial,
and antifungal activities. Natural quinolinequinones have also been known for their significant
activities. The review highlights the diverse biological activities exhibited by synthetic quinoline-
5,8-diones over the past two decades. Continued research in this field is warranted to fully exploit
the therapeutic potential of these intriguing compounds and their derivatives for future drug development.
By comprehensively evaluating the therapeutic applications and biological activities of
quinoline-5,8-dione derivatives, this review endeavors to provide researchers and practitioners with
a valuable resource that will foster informed decision-making and inspire further investigations into
harnessing the immense potential of this intriguing scaffold for the benefit of human health.
A Novel Polytope Algorithm based On Nelder-mead Method for
Localization in Wireless Sensor Network
Authors: Gumaida Bassam , Ibrahim Adamu Abubakar 
Published: January 2024

Background and Objective:
Magnificent localization precision and low operating expenses
are the main keys and essential issues to managing and operating outdoor wireless sensor
networks. This work proposes a novel and rigorous efficiency localization algorithm utilizing a simplex
optimization approach for node localization. This novel optimization method is a direct search
approach, and is usually directed to solve nonlinear optimization problems that may not have wellknown
derivatives, and it is called the Nelder-mead Method (NMM).

Methods:
It is suggested that the objective function that will be optimized using NMM is the mean
squared error of the range of all neighboring anchor nodes installed in the studied WSNs. This paper
emphasizes employing a ranging technique called Received Signal Strength Indicator (shortly RSSI)
to calculate the length of distances among all the nodes of WSNs.

Results:
Simulation results perfectly showed that the suggested localization algorithm based on
NMM can carry out a better performance than that of other localization algorithms utilizing other optimization
approaches, including a particle swarm optimization, ant colony (ACO) and bat algorithm
(BA). This obviously appeared in several metrics of performance evaluation, such as accuracy of localization,
node localization rate, and implementation time.

Conclusions:
The proposed algorithm that utilized NMM is more functional to enhance the precision
of localization because of particular characteristics that are the flexible implementation of NMM and
the free cost of using the RSSI technique.
The Psychological Health and Professional Well-being of Operators
Working with Forced Migrants in Italy: A Cross-sectional
Epidemiological Study
Authors: Tessitore Francesca , Caffieri Alessia , Giordano Claudia , Celia Giovanna , Margherita Giorgia 
Published: January 2024

Abstract:
Although the related dimensions of professional quality of life, secondary traumatic
stress, and emotion regulation have been widely investigated in the field of helping
and healthcare professionals, these dimensions combined have scarcely been explored in
the field of workers with forced migrants. The aims of the present study are twofold. First,
it aims to investigate the prevalence of secondary traumatic stress levels, emotion regulation,
burnout, and compassion satisfaction in professionals working with forced migrants
in Italy. Second, it aims to explore the associations between some socio-demographic and
work-related characteristics and the psychological health and professional well-being status
of professionals. An online survey was administered via Google Modules to the Italian
associations and Third Sector entities working in the field of forced migration from May
2021 to March 2022. A total of 264 professionals (mean age: 39.9; 76.1% females) responded
to the survey. On the background of good levels of psychological health and professional
well-being, significant differences emerged in mental health status and professional
quality of life related to professional roles, age, gender, and geographic provenience.
Understanding the psychological health and professional well-being of those working with
asylum seekers and refugees is crucial in providing appropriate supportive healthcare interventions
which might be able to take care of professionals’ well-being as well as of their
beneficiaries themselves.
Safety profile between fluoxetine and sertraline as antidepressants for pregnant women with depression disorder
Authors: Dewa Ayu Sri Handani  , Mustikawati Maria Sri Ayu , Parwatininghati Ni Putu , Zulkarnaen  , Akuba Jusnita 
Published: January 2024

Depression disorders are common in women of productive age, especially during pregnancy and peripartum period. Making a decision on the choosing of antidepressants is associated to the biggest concern about the risk of birth defects and major anomalies of their exposure. Decisions of antidepressant use not only involve considering the risks of medications exposure, but also the risks of untreated depression during pregnancy. Evaluation of the safety profile of selective reuptake inhibitors (SSRIs) which are commonly prescribed during pregnancy therefore urgently needed. This review aimed to compare two widely used SSRIs i.e. fluoxentine and sertraline as antidepressants for pregnant women with depression disorder. It is found that sertraline has more positive effects and more safe. Sertraline is well tolerated in pregnant women and breastfeeding mothers with depression disorder.
Safety monitoring of chloroquine and hydroxychloroquine in COVID-19 patients in Indonesia on QT prolongation: hospital based monitoring study
Authors: Jarir At Thobari  , Togi Junice Hutadjulu  , Tri Asti Isnariani  , Umi Sa'adatun Nikmah  , Lukman Ade Chandra  , Pompini Agustina Sitompul  , Anggoro Budi Hartopo  , Rizki Amalia Gumilang  , Luhur Pribadi  , Deva Bachtiar  , Anwar Santoso  
Published: January 2024

Chloroquine (CQ) and Hydroxychloroquine (HCQ) are the challenging drugs used for COVID-19. Several studies show its beneficial, however, both medications can prolong the QTc interval and increase the risk of patients for torsades de pointes and death. The Tisdale score is identified to have successfully predicted the at-risk population of side effects of these drugs. This study aim to evaluate the QT prolongation caused by the administration of chloroquine and hydroxychloroquine in COVID-19 patients and the association with the treatment outcomes based on their Tisdale score. We conducted an observational study on 213 hospitalized patients with confirmed or suspect COVID-19 in 6 referral hospitals in Indonesia. All baseline demographic such as age and gender, RT-PCR test result, severity of disease, history of cardiovascular disease (myocardial infarction, heart failure, hypertension), serum kalium level at baseline, and the use of medication associated with risk QTc interval prolongation were collected. The Tisdale risk score was used for predicting high-risk patients for QT corrected (QTc) interval prolongation. Out of 213 patients who were treated with CQ/HCQ, there were 60 (28.2%) patients had QTc interval prolongation, included 43 patients (20.2%) who had normal QTc interval at baseline and at the end of treatment had prolong interval; or 17 patients (8.0%) who had QTc interval more than 470 msec at baseline and QTc interval prolongation was worsen at the end of treatment. Several factors, including age more than 50 years, COVID-19 confirm PCR, and had comorbidity heart failure, were statistically significant associated with QTc interval prolongation. The high-risk score of Tisdale score have increased risk significantly on QTc interval prolongation (RR: 2.15, 95%CI 1.07-4.32) and associated with risk of death (RR: 3.50, 95%CI 1.34-9.13) compared to low-risk score. Our findings showed that the treatment of CQ/HCQ in COVID-19 patients is associated with QTc prolongation. The Tisdale score can be used as a valuable tool to predict the COVID-19 patients’ outcome after treatment of these QTc-prolonging drugs.
Physical properties and stability of grapeseed oil (Vitis vinifera L.) skincare formula with gelling agent combination of Na-CMC-carbopol and HPMC-carbopol
Authors: Abdul Karim Zulkarnain  , Chairunnisa Nurul Ichsani  , Candriya Lael Judiantoro  
Published: January 2024

Skincare products made from natural ingredients have become the choice of many people. Grapeseed oil contains ingredients that act as a moisturizer. Na-CMC-carbopol and HPMC-carbopol are gelling agents that are widely used in preparations due to their compatibility with various materials. All three are combined to cover their respective deficiencies. This study aimed to evaluate the effect of the combination of Na-CMC-carbopol and HPMC-carbopol on the physical properties and stability of grapeseed oil gel and to determine the optimum formula. The research method was carried out by optimizing the levels of Na-CMC (2-2.5%), HPMC (2-20%), and carbopol (0.5-1%) with the Simplex Lattice Design method. Eight runs of the resulting formula were gelled and tested for their physical properties to determine the optimum formula. The optimum formula obtained was verified with statistical analysis and tested for physical stability. The stability data were analyzed statistically, 95% confidence level. The optimum formula for NaCMC-carbopol was at a concentration of 2.220% Na-CMC and 0.780% carbopol, pH 6.246 ± 0.057, spreadability 12.96 ± 0.48 cm2, adhesion 6.33 ± 0.48 sec, viscosity 166.00 ± 4.88 dPas. HPMC-carbopol at both concentrations of 1% had a pH of 4.973 ± 0.172, a viscosity of 175.20 ± 5.44 dPas, a spreadability of 18.12 ± 1.61 cm2, and an adhesion of 6.94 ± 1.68 sec. All preparations were not significantly different between predictions and experiments. The optimum gel formula had good physical properties and was stable during 3 cycles of cycling stability test.
The role of angiotensin I - converting enzyme (ACE) insertion/deletion gene polymorphism in hypertension and ACE inhibitor therapy: a narrative review
Authors: Handani Dewa Ayu Sri , Zullies Ikawati  , Hermawan Adam 
Published: January 2024

Primary hypertension is the most prevalent type of hypertension, which is primarily attributed to genetic factors. The angiotensin-converting enzyme (ACE) gene has emerged as a prominent candidate among the genetic factors influencing blood pressure regulation. The ACE gene encodes the ACE, which plays a crucial role in the renin-angiotensin system. The ACE gene insertion/deletion (I/D) polymorphism is a variation of the ACE gene that affects blood pressure regulation. Individuals with II, ID, and DD genotypes may exhibit distinct ACE plasma concentrations, potentially contributing to variations in blood pressure levels and response to ACE inhibitor therapy. This article aimed to provide a comprehensive overview of the relationship between the ACE I/D gene with hypertension and angiotensin-converting enzym inhibitor (ACEI) effectiveness. This article presents a narrative review encompassing relevant studies published between 2013 and 2023. A systematic search was conducted using reputable databases such as PubMed, Science Direct, and Scopus. Inclusion criteria were applied, resulting in the selection of 25 articles that met the predefined criteria. The analysis included 25 studies, comprising 5 articles that investigated the impact of ACEI therapy and 20 articles that examined the ACE I/D gene polymorphism in hypertensive populations without ACEI therapy. It can be concluded that compared to the I allele, the D allele of the ACE I/D gene is associated with a higher level of essential hypertension and a reduced ACEI response.