bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of the impact of procedure time and the ‘golden hour’ in subpopulations of stroke thrombectomy patients
Authors: Ash Makenna , Dimisko Laurie , Chalhoub Reda M , Howard Brian M , Cawley C Michael , Matouk Charles , Pabaney Aqueel , Spiotta Alejandro M , Jabbour Pascal , Maier Ilko , Wolfe Stacey Q , Rai Ansaar T , Kim Joon-tae , Psychogios Marios-Nikos , Mascitelli Justin R , Starke Robert M , Shaban Amir , Yoshimura Shinichi , De Leacy Reade , Kan Peter , Fragata Isabel , Polifka Adam J , Arthur Adam S , Park Min S , Crosa Roberto Javier , Williamson Richard , Dumont Travis M , Levitt Michael R , Al Kasab Sami , Tjoumakaris Stavropoula I , Liman Jan , Saad Hassan , Samaniego Edgar A , Fargen Kyle M , Grossberg Jonathan A , Alawieh Ali 
Published: October 2023

ObjectiveTo evaluate the effect of procedure time on thrombectomy outcomes in different subpopulations of patients undergoing endovascular thrombectomy (EVT), given the recently expanded indications for EVT.MethodsThis multicenter study included patients undergoing EVT for acute ischemic stroke at 35 centers globally. Procedure time was defined as time from groin puncture to successful recanalization (Thrombolysis in Cerebral Infarction score ≥2b) or abortion of procedure. Patients were stratified based on stroke location, use of IV tissue plasminogen activator (tPA), Alberta Stroke Program Early CT score, age group, and onset-to-groin time. Primary outcome was the 90-day modified Rankin Scale (mRS) score, with scores 0–2 designating good outcome. Secondary outcome was postprocedural symptomatic intracranial hemorrhage (sICH). Multivariate analyses were performed using generalized linear models to study the impact of procedure time on outcomes in each subpopulation.ResultsAmong 8961 patients included in the study, a longer procedure time was associated with higher odds of poor outcome (mRS score 3–6), with 10% increase in odds for each 10 min increment. When procedure time exceeded the ‘golden hour’, poor outcome was twice as likely. The golden hour effect was consistent in patients with anterior and posterior circulation strokes, proximal or distal occlusions, in patients with large core infarcts, with or without IV tPA treatment, and across age groups. Procedures exceeding 1 hour were associated with a 40% higher sICH rate. Posterior circulation strokes, delayed presentation, and old age were the variables most sensitive to procedure time.ConclusionsIn this work we demonstrate the universality of the golden hour effect, in which procedures lasting more than 1 hour are associated with worse clinical outcomes and higher rates of sICH across different subpopulations of patients undergoing EVT.
Coil embolization of distal vascular lesion using a 1.5 Fr Marathon microcatheter and ‘free-running’ technique
Authors: Ou Chang-Hsien , Cheng Chiu-Shih , Winardi William , Lin Pei-Ling , Lee Cheng-Lung , Lin Wan-Ching 
Published: October 2023

In distal vascular lesions, such as the distal anterior inferior cerebellar artery or posterior inferior cerebellar artery (PICA) dissecting aneurysm, and dural arteriovenous fistula (dAVF) and arteriovenous malformation (AVM), super-selective catheterization and embolization using liquid agents, such as NBCA or Onyx liquid embolic system, is the preferred treatment.1 2 We used a flow-directed 1.5 Fr Marathon microcatheter (Medtronic, Minneapolis, MN, USA) for embolization because commonly used detachable coil-compatible microcatheters can be too short or rigid for superselection.3–6 We designed an in vitro coil compatibility test for the Marathon microcatheter and developed a ‘free-running’ technique (video 1). Using this technique, we trapped the distal PICA dissecting aneurysm and embolized the fistula points of dAVF precisely and safely without affecting adjacent normal structures, which can occur when applying liquid embolizing agents.1–3 After reviewing the case, we determined that this technique can also potentially be applied for implementing the pressure cooker technique7 and combining the management of AVM.4Video 1Free-running technique via 1.5 Fr Marathon microcatheter
Superior hypophyseal arteries: angiographic re-discovery, comprehensive assessment, and embryologic implications
Authors: Shapiro Maksim , Sharashidze Vera , Nossek Erez , Sen Chandra , Rutledge Caleb , Chung Charlotte , Khawaja Ayaz , Kvint Svetlana , Riina Howard , Nelson Peter Kim , Raz Eytan 
Published: October 2023

The superior hypophyseal arteries (SHAs) are well known in anatomical and surgical literature, with a well-established role in supply of the anterior hypophysis and superjacent optic apparatus. However, due to small size and overlap with other vessels, in vivo imaging by any modality has been essentially non-existent. Advances in high resolution cone beam CT angiography (CBCTA) now enables this deficiency to be addressed. This paper presents, to the best of our knowledge, the first comprehensive in vivo imaging evaluation of the SHAs.MethodsTwenty-five CBCTA studies of common or internal carotid arteries were obtained for a variety of clinical reasons. Dedicated secondary reconstructions of the siphon were performed, recording the presence, number, and supply territory of SHAs. A spectrum approach, emphasizing balance with adjacent territories (inferior hypophyseal, ophthalmic, posterior and communicating region arteries) was investigated.ResultsThe SHAs were present in all cases. Supply of the anterior pituitary was nearly universal (96%) and almost half (44%) originated from the ‘cave’ region, in excellent agreement with surgical literature. Optic apparatus supply was more difficult to adjudicate, but appeared present in most cases. The relationship with superior hypophyseal aneurysms was consistent. Patency following flow diverter placement was typical, despite a presumably rich collateral network. Embryologic implications with respect to the ophthalmic artery and infraoptic course of the anterior cerebral artery are intriguing.ConclusionsSHAs are consistently seen with CBCTA, allowing for correlation with existing anatomical and surgical literature, laying the groundwork for future in vivo investigation.
Immediate smoking cessation support during lung cancer screening: long-term outcomes from two randomised controlled trials
Authors: Williams Parris J , Philip Keir E J , Buttery Sara C , Perkins Alexis , Chan Ley , Bartlett Emily C , Devaraj Anand , Kemp Samuel V , Addis James , Derbyshire Jane , Chen Michelle , Polkey Michael I , Laverty Anthony A , Hopkinson Nicholas S 
Published: October 2023

BackgroundImmediate smoking cessation interventions delivered alongside targeted lung health checks (TLHCs) to screen for lung cancer increase self-reported abstinence at 3 months. The impact on longer term, objectively confirmed quit rates remains to be established.MethodsWe followed up participants from two clinical trials in people aged 55–75 years who smoked and took part in a TLHC. These randomised participants in the TLHC by day of attendance to either usual care (UC) (signposting to smoking cessation services) or an offer of immediate smoking cessation support including pharmacotherapy. In the QuLIT1 trial, this was delivered face to face and in QuLIT2, it was delivered remotely. Follow-up was conducted 12 months after the TLHC by telephone interview with subsequent biochemical verification of smoking cessation using exhaled CO.Results430 people were enrolled initially (115 in QuLIT1 and 315 in QuLIT2), with 4 deaths before 12 months leaving 426 (62.1±5.27 years old and 48% women) participants for analysis. At 12 months, those randomised to attend on smoking cessation support intervention days had higher quit rates compared with UC adjusted for age, gender, deprivation, and which trial they had been in; self-reported 7-day point prevalence (20.0% vs 12.8%; adjusted OR (AOR)=1.78; 95% CI 1.04 to 2.89) and CO-verified quits (12.1% vs 4.7%; AOR=2.97; 95% CI 1.38 to 6.90). Those in the intervention arm were also more likely to report having made a quit attempt (30.2% vs UC 18.5%; AOR 1.90; 95% CI 1.15 to 3.15).ConclusionProviding immediate smoking cessation support alongside TLHC increases long term, biochemically confirmed smoking abstinence.Trial registration numberISRCTN12455871.
Evaluation of carbon dioxide sequestration via interaction with peridotite and peridotite-hosted groundwaters: an experimental case study with Bay of Islands Ophiolite rocks, western Newfoundland, Canada
Authors: Gill M.J. , Poduska K.M. , Morrill P.L. 
Published: October 2023

This study measured the CO2 gas flux into various aqueous media (i.e., simulated ultra-basic and basic groundwater, and deionized water) containing ultramafic rock. Basic and ultra-basic waters simulated the aqueous chemistry and ion concentrations of distinct groundwaters found within terrestrial ultramafic bodies. Experiments were performed in a closed chamber in-line with a CO2 analyzer, which measured the gaseous CO2 concentration in the chamber every second. Total inorganic carbon, as well as aqueous species Ca, Mg, and Si were monitored in the reaction fluids. All three fluid types sequestered CO2. The addition of crushed peridotite to deionized water reduced the CO2 concentration in the headspace by 70 ppm (±9 ppm, 1σ, n = 3) and had a calculated CO2 flux of −2.5 × 104 mol/m2min (±9 × 105 mol/m2min, 1σ, n = 3), while the greatest CO2 flux was observed in ultra-basic Ca-rich waters of −1.40 × 103 mol/m2min (±3 × 105 mol/m2min, 1σ, n = 3), which reduced the headspace CO2 concentration by 323 ppm (±4 ppm, 1σ, n = 3). The presence of calcite was detected using FTIR in ultra-basic waters in the presence and absence of ultramafic rock. A carbon mass balance model indicated that solid carbonates were precipitated in the ultra-basic water experiments, converting up to 59% of the CO2 removed from the chamber headspace in 4 h. Extrapolating the data collected in these experiments, it was estimated that at surface conditions, with an adequate residence time, the mass of ultramafic rock in the Bay of Islands Complex in Newfoundland could sequester up to 4 million tonnes of atmospheric CO2.
Effects of exact kinematics and the Sudakov form factor on the dipole amplitude
Authors: Goda T. , Kutak K. , Sapeta S. 
Published: October 2023

AbstractWe investigate the effects of exact gluon kinematics on the parameters of the Golec-Biernat–Wüsthoff, and Bartels–Golec-Biernat–Kowalski saturation models. The resulting fits show some differences, particularly, in the normalization of the dipole cross section $$\sigma _0$$

σ
0

. The refitted models are used for the dijet production process in DIS to describe HERA data and investigate the effects of the Sudakov form factor at the future Electron Ion Collider.
Cell State of Origin Impacts Development of Distinct Endometriosis-Related Ovarian Carcinoma Histotypes
Authors: Beddows Ian , Fan Huihui , Heinze Karolin , Johnson Benjamin K. , Leonova Anna , Senz Janine , Djirackor Svetlana , Cho Kathleen R. , Pearce Celeste Leigh , Huntsman David G. , Anglesio Michael S. , Shen Hui 
Published: October 2023

Abstract

Clear cell ovarian carcinoma (CCOC) and endometrioid ovarian carcinoma (ENOC) are ovarian carcinoma histotypes, which are both thought to arise from ectopic endometrial (or endometrial-like) cells through an endometriosis intermediate. How the same cell type of origin gives rise to two morphologically and biologically different histotypes has been perplexing, particularly given that recurrent genetic mutations are common to both and present in nonmalignant precursors. We used RNA transcription analysis to show that the expression profiles of CCOC and ENOC resemble those of normal endometrium at secretory and proliferative phases of the menstrual cycle, respectively. DNA methylation at the promoter of the estrogen receptor (ER) gene (ESR1) was enriched in CCOC, which could potentially lock the cells in the secretory state. Compared with normal secretory-type endometrium, CCOC was further defined by increased expression of cysteine and glutathione synthesis pathway genes and downregulation of the iron antiporter, suggesting iron addiction and highlighting ferroptosis as a potential therapeutic target. Overall, these findings suggest that while CCOC and ENOC arise from the same cell type, these histotypes likely originate from different cell states. This “cell state of origin” model may help to explain the presence of histologic and molecular cancer subtypes arising in other organs.

Significance:
Two cancer histotypes diverge from a common cell of origin epigenetically locked in different cell states, highlighting the importance of considering cell state to better understand the cell of origin of cancer.
SKP2 Knockout in Rb1/p53–Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis
Authors: Ferrena Alexander , Wang Jichuan , Zhang Ranxin , Karadal-Ferrena Burcu , Al-Hardan Waleed , Singh Swapnil , Borjihan Hasibagan , Schwartz Edward L. , Zhao Hongling , Oktay Maja H. , Yang Rui , Geller David S. , Hoang Bang H. , Zheng Deyou 
Published: October 2023

AbstractOsteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma is SKP2, encoding a substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that Skp2 knockout in murine osteosarcoma improved survival and delayed tumorigenesis. Here, we performed RNA sequencing (RNA-seq) on tumors from a transgenic osteosarcoma mouse model with conditional Trp53 and Rb1 knockouts in the osteoblast lineage (“DKO”: Osx1-Cre;Rb1lox/lox;p53lox/lox) and a triple-knockout model with additional Skp2 germline knockout (“TKO”: Osx1-Cre;Rb1lox/lox;p53lox/lox;Skp2−/−), followed by qPCR and immunohistochemistry validation. To investigate the clinical implications of our results, we analyzed a human osteosarcoma patient cohort (“NCI-TARGET OS”) with RNA-seq and clinical data. We found large differences in gene expression after SKP2 knockout. Surprisingly, we observed increased expression of genes related to immune microenvironment infiltration in TKO tumors, especially the signature genes for macrophages and to a lesser extent, T cells, B cells, and vascular cells. We also uncovered a set of relevant transcription factors that may mediate these changes. In osteosarcoma patient cohorts, high expression of genes upregulated in TKO was correlated with favorable overall survival, which was largely explained by the macrophage gene signatures. This relationship was further supported by our finding that SKP2 expression was negatively correlated with macrophage infiltration in the NCI-TARGET osteosarcoma and the TCGA Sarcoma cohorts. Overall, our findings indicate that SKP2 may mediate immune exclusion from the osteosarcoma tumor microenvironment, suggesting that SKP2 modulation in osteosarcoma may induce antitumor immune activation.
A Theoretically Grounded Question Answering Data Set for Evaluating
Machine Common Sense
Authors: Santos Henrique , Shen Ke , Mulvehill Alice M. , Kejriwal Mayank , McGuinness Deborah L. 
Published: October 2023

ABSTRACT
Achieving machine common sense has been a longstanding problem within Artificial Intelligence. Thus far, benchmark data sets that are grounded in a theory of common sense and can be used to conduct rigorous, semantic evaluations of common sense reasoning (CSR) systems have been lacking. One expectation of the AI community is that neuro-symbolic reasoners can help bridge this gap towards more dependable systems with common sense. We propose a novel benchmark, called Theoretically Grounded common sense Reasoning (TG-CSR), modeled as a set of question answering instances, with each instance grounded in a semantic category of common sense, such as space, time, and emotions. The benchmark is few-shot i.e., only a few training and validation examples are provided in the public release to avoid the possibility of overfitting. Results from recent evaluations suggest that TG-CSR is challenging even for state-of-the-art statistical models. Due to its semantic rigor, this benchmark can be used to evaluate the common sense reasoning capabilities of neuro-symbolic systems.
Beckett’s Prose Fiction and Waiting for Godot
Authors: Engelberts Matthijs 
Published: October 2023

Abstract
Waiting for Godot is not often presented as homologous with Beckett’s narrative fiction. However, a close consideration of the status of the boy(s) in the play shows that the drama text undermines the dichotomy between inner and outer world, which Beckett was addressing in comparable ways in his novels and art criticism.
Mapping Postcolonial Marginalisation and Reactive/Adaptive Models of Masculinity
Authors: Mutekwa Anias 
Published: October 2023

Abstract
This article examines the representation of postcolonial marginalisation and adaptive/reactive models of masculinity in NoViolet Bulawayo’s novel, We Need New Names. It focuses on the representations of masculinities in the text and their ramifications and entanglements at the global, regional and local levels. The analysis is mediated via a triangulation of the concepts of hegemonic masculinity, masculine (over)compensation and masculine hybridisation. It establishes that a culture of both hegemony and domination mediates and permeates masculine relations resulting in the enactment of reactive and adaptive responses in the form of both masculine (over)compensation and masculine hybridisation. These responses are mainly enacted by those subaltern masculinities who are at the receiving end of domination and hegemony. Additionally, these responses favour the enhancement of male domination and/or patriarchy as opposed to gender equality. They also do not favour the promotion of a culture of tolerance, democracy and/or human rights discourses that are central to the realities of much of the contemporary world.
Retracted article: Barbarism – The Active Dystopia
Authors: Palmer Jack 
Published: October 2023

This is a retracted article, whose corrected version, bearing the same title, is avalaible under the DOI: https://doi.org/10.11649/slh.3125. The article was corrected on request of the author, who noted that some of his corrections had not been introduced in the text. The publisher sincerely apologises for the oversight. In this article, I argue that dystopia also has an ambivalently “active” function in Bauman’s sociology. Across his work, as a counter-image to the “active utopia” of socialism, the traces of the “active dystopia” can be tracked, defined as a pointed elucidation of the possibilities for barbarism latent within the present, the clearest expression of which is presented in Modernity and the Holocaust (1989). The article proceeds roughly in three steps. Firstly, I revisit the arguments in Bauman’s foundational cultural and critical sociology that developed alongside his revisionist reading of Marxism in the 1960s and 1970s, on epistemologies of the future, common sense and the limitations of the predictive ambitions of social science. Then, I develop a particular focus on an unpublished, though essential, typescript entitled “Is the Science of the Possible Possible?”, suggesting that it is usefully read in terms of the emphasis on possibility and potentiality in Modernity and the Holocaust. Throughout these sections, I intersperse a reading of Modernity and the Holocaust in the light of this foundational work, presenting it as an exemplary form of critical sociology as active dystopia, which elucidates the possibility for barbarism residing within modern societies. Finally, I consider how his thinking situates him in a lineage of critical thought animated by the “active dystopia”, arguing that what is often mistaken for gloominess and pessimism is, in fact, a crucial resource for sociology in its speculative imagination of possible futures.
Endovascular Recanalization of Aortic Isthmus Atresia with an “Electrified Wire Technique”
Authors: Arulrajah Kugarajah , Spanos Konstantinos , Panuccio Giuseppe , Gandet Thomas , Rickers Carsten , Kölbel Tilo 
Published: October 2023

Purpose: For aortic coarctation in adults endovascular repair is the treatment of choice with an acceptable safety profile. Aortic isthmus atresia is a related condition with a complete occlusion of the aorta not allowing catheterization across the isthmus. This technical note describes a recanalization of an aortic isthmus atresia using radiofrequency with an “electrified wire technique.” Technique: A guidewire was selectively denuded of PTFE (polytetrafluoroethylene) at the distal end and was placed through a catheter distal to the aortic isthmus atresia. The denuded end of the wire was clamped to an electrosurgery pencil. By pushing the wire toward a tulip-snare, which was placed as a target proximal of the occlusion via left trans-brachial access, and shortly activating of the electrosurgery pencil the electrified wire recanalized the occlusion and was snared and used to guide implantation of a balloon-expandable covered stent. Conclusion: The electrified wire puncture technique can be used to recanalize adult aortic isthmus atresia after failed conventional attempts. Clinical Impact The electrified wire technique offers an off-the shelf option to modify standard guidewires for the use with radiofrequency to cross a complete aortic isthmus occlusion after failed conventional attempts. This new technique may be applied also in other situations like dissection flap fenestration, transcaval access and similar.
Tumor response assessment by measuring the single largest lesion per organ in advanced non-small cell lung cancer patients treated with PD-1/PD-L1 inhibitor
Authors: He Li-Na , Chen Tao , Fu Sha , Jiang Yongluo , Zhang Xuanye , Chen Chen , Du Wei , Luo Linfeng , Li Anlin , Wang Yixing , Yu Hui , Zhou Yixin , Wang Yuhong , Yang Yunpeng , Huang Yan , Zhao Hongyun , Fang Wenfeng , Zhang Li , Hong Shaodong 
Published: October 2023

Background: For Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST1.1), measuring up to two target lesions per organ is an arbitrary criterion. Objectives: We sought to compare response assessment using RECIST1.1 and modified RECIST1.1 (mRECIST1.1, measuring the single largest lesion per organ) in advanced non-small cell lung cancer (aNSCLC) patients undergoing anti-PD-1/PD-L1 monotherapy. Methods: Concordance of radiologic response categorization between RECIST1.1 and mRECIST1.1 was compared using the Kappa statistics. C-index was calculated to evaluate prognostic accuracy of radiologic response by the two criteria. The Kaplan–Meier method and Cox regression analysis were conducted for progression-free survival (PFS) and overall survival (OS). Results: Eighty-seven patients who had at least two target lesions in any organ per the RECIST1.1 were eligible for comparison analysis. Tumor response showed excellent concordance when measured using the RECIST1.1 and mRECIST1.1 (Kappa = 0.961). C-index by these two criteria was similar for PFS (0.784 versus 0.785) and OS (0.649 versus 0.652). Responders had significantly longer PFS and OS versus non-responders ( p < 0.05), whichever criterion adopted. Radiologic response remained a significant predictor of PFS and OS in multivariate analysis ( p < 0.05). Conclusion: The mRECIST1.1 was comparable to RECIST1.1 in response assessment among aNSCLC patients who received single-agent PD-1/PD-L1 inhibitor. The mRECIST1.1, with reduced number of lesions to be measured, may be sufficient and more convenient to assess antitumor activity in clinical practice.