bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photophobia is associated with lower sleep quality in individuals with migraine: Results from the American Registry for Migraine Research (ARMR)
Authors: Sharp Nina , Burish Mark J , Digre Kathleen B , Ailani Jessica , Fani Mahya , Lamp Sophia , Schwedt Todd J. 
Published: January 2024

Abstract
Background. Patients with migraine often have poor sleep quality between and during migraine attacks. Furthermore, extensive research has identified photophobia as the most common and most bothersome symptom in individuals with migraine, second only to headache. Seeking the comfort of darkness is a common strategy for managing pain during an attack and preventing its recurrence between episodes. Given the well-established effects of daily light exposure on circadian activity rhythms and sleep quality, this study aims to investigate the relationship between photophobia symptoms and sleep quality in a cohort of patients with migraine.
Methods. A cross-sectional observational study was conducted using existing data extracted from the American Registry for Migraine Research (ARMR). Participants with a migraine diagnosis who had completed the baseline questionnaires (Photosensitivity Assessment Questionnaire (PAQ), Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-2 (PHQ-2)), and selected questions of the ARMR Sleep questionnaire were included. Models were created to describe the relationship of photophobia and photophilia with various sleep facets, including sleep quality (SQ), sleep disturbance (SDis), sleep onset latency (SOL), and sleep-related impairments (SRI). Each model was controlled for age, sex, anxiety, and depression.
Results. A total of 852 patients meeting the inclusion criteria were included in the analysis (mean age (SD) = 49.8 (13.9), 86.6% (n = 738) female). Those with photophobia exhibited significantly poorer sleep quality compared to patients without photophobia (p < 0.001). Photophobia scores were associated with SQ (p < 0.001), SDis (p < 0.001), SOL (p = 0.011), and SRI (p = 0.014), after controlling for age, sex, depression, and anxiety, signifying that higher levels of photophobia were associated with worse sleep-related outcomes. Conversely, photophilia scores were associated with better sleep-related outcomes for SQ (p < 0.001), SDis (p < 0.001), and SOL (p = 0.016).
Conclusion. Results suggest that photophobia is a risk factor for sleep disorders in those with migraine. These results underscore the necessity for comprehensive and systematic investigations into the intricate interplay between photophobia and sleep to enhance our understanding and develop tailored solutions for individuals with migraine.
Explainable Machine Learning to Uncover Distinct Phenotypic Signatures of Hypertrophic Cardiomyopathy and Fabry Disease
Authors: Ramchand Suraj , Ploszajski Matthew , Virdi Avraj , Cole Duncan , Xie Xianghua 
Published: January 2024

Abstract
Background: Fabry Disease (FD) is a rare metabolic condition, characterised by a wide range of symptoms and progressive deterioration of the heart, kidneys and nervous system. The condition often goes undiagnosed for between 3-10 years, with misdiagnoses during this period being common. A historically common misdiagnosis for FD is Hypertrophic Cardiomyopathy (HCM). This condition mimics the cardiac symptoms of FD, although it does not share the same genetic pathology. Machine learning (ML) is a subfield of artificial intelligence that has shown promise in identifying rare diseases, including FD. This study builds on previous research to identify FD in routine clinical test data and provide a robust explainability framework.
Methods: Cardiac test data (ECG, Holter and Echo) was extracted for 100 HCM and 49 FD patients. Stratified repeated K-fold cross-validation procedure was employed to select the optimum ML classifier. Following this, we explored a range of ML models and ensembling approaches. Each tuned classifier was trained on this data to identify differences between the experimental groups. Feature importance, SHAP values and partial dependence plots were generated to explain the model's decision-making process.
Results: Following cross-validation, the Extreme Gradient Boosting (XGB) classifier emerged as the most reliable classification algorithm (AUC and F1 score: 0.92). T-axis, gender and age were revealed as consistently being the primary features used by the model for classification predictions.
Conclusion: XGB proved to be a reliable classifier between FD and HCM for this dataset. The most important features largely aligned with established clinical approaches to differentiating phenotypes between HCM and FD. Future work should aim to compare the performance of this model against expert clinicians to compare these methods to the human state of the art.
Risk perception, well-being, depression and anxiety in children and adolescents with rheumatic diseases during the COVID-19 pandemic - results from the prospective multicenter KICK-COVID study in Germany
Authors: Sengler Claudia , Klotsche Jens , Pedersen Malthe Jessen , Niewerth Martina , Göldel Julia , Windschall Daniel , Haas Johannes-Peter , Dressler Frank , Trauzeddel Ralf , Hospach Anton , Weller-Heinemann Frank , Lanzinger Stefanie , Kamrath Clemens , Holl Reinhard W , Warschburger Petra , Minden Kirsten 
Published: January 2024

Abstract

Objective
To investigate the psychosocial burden in children and adolescents with juvenile rheumatic diseases during the COVID-19 pandemic.
Methods
As part of the multicentre observational KICK-COVID study linked to the National Pediatric Rheumatology Database, adolescents < 21 years and parents of children < 12 years with rheumatic diseases answered questions on perceptions of health risk (PHR) due to SARS-CoV2, stress, well-being (WHO-5) and symptoms of depression (PHQ-9) and anxiety (GAD-7). Data were collected at routine visits from June to December 2021 and assessed for association with demographic and clinical parameters, treatment and patient-reported outcomes.
Results
Data from 1356 individuals (69% female, 50% adolescents) were included. Median PHR on a numeric rating scale (NRS, 0–10) was 4 (IQR 2–6), median perceived stress was 3 (IQR 1–6). Adolescents reported a worse well-being with a significantly lower median WHO-5-score (60, IQR 40–76) than parents reported for their children < 12 years (80, IQR 68–84). Moderate to severe symptoms of depression and anxiety were reported by 14.3% and 12.3% of the adolescents, respectively. PHR was significantly higher in patients with systemic lupus erythematosus, methotrexate or biologic disease-modifying anti-rheumatic drug therapy than in patients without these characteristics, whereas lower WHO-5 or higher PHQ-9 or GAD-7 scores were only associated with poorer patient-reported health status and physical functioning.
Conclusion
The perception of health risk due to SARS-CoV2 infection was not paralleled by an impairment of mental health and well-being, which were, however, significantly correlated with self-rated health status and functional capacity, highlighting the importance of patient-reported outcome assessment.
Trial registration:
German Clinical Trials Register (DRKS), no. DRKS00027974. Registered on 27th of January 2022.
Divergent renal localization patterns of heterozygote-derived two distinct AA amyloids in a cat
Authors: Kobayashi Natsumi , Kaneda Masahiro , Iwaide Susumu , Itoh Yoshiyuki , Hisada Miki , Kato Yuka , Masoud Niki Sedghi , Tsuneyasu Machie , Akamine Tomoko , Murakami Tomoaki 
Published: January 2024

Abstract
Amyloid A (AA) amyloidosis poses a fatal threat to both humans and animals. While the kidneys represent the principal organ affected in AA amyloidosis, there exists variability in the localization of amyloid deposition, with distinct symptoms delineated by the specific deposition sites. Nevertheless, the factors contributing to the diversity of deposition remain unclear. In this study, we identified an association between serum amyloid A (SAA) polymorphisms and patterns of amyloid deposition. Histopathological analysis of the kidneys from a 5-year-old spayed female Japanese cat, which succumbed to systemic AA amyloidosis, revealed renal amyloid deposition in cortical glomeruli and medullary interstitium. Genetic analysis disclosed that the afflicted cat possessed a heterozygous SAA with three amino acid substitutions (K47I, Q63R, S93N), resulting in the SAAKQS and SAAIRN variants. Mass spectrometry and immunohistochemistry demonstrated that SAAKQS was deposited in the glomerulus and renal papilla, while SAAIRN was restricted to the extramedullary zone. This study established the differing renal distributions of two AA amyloid variants originating from heterozygotes within a single individual. The evidence supports the notion that the primary structure of precursor proteins defines the distribution of amyloid deposition.
Effects of NaClO 2 bleaching temperature on the properties of epoxy/lignin transparent wood composites for UV-shielding window applications
Authors: Van Hai Le , Cho Seung-Woo , Kwon Gu-Joong , Bandi Rajkumar , Kim Jeong-Ki , Han Song-Yi , Dadigala Ramakrishna , Lee Da-Young , Ma Seo-Young , Lee Seung-Hwan 
Published: January 2024

Abstract
The effect of NaClO2 bleaching temperature on the properties of epoxy-resin (ER) transparent wood (TW) and ER/lignin-TW for ultraviolet-shielding (UV-shielding) window applications is investigated. Higher bleaching temperatures result in greater lignin removal and TW transmittance, with a reduced TW UV-shielding functionality. To enhance the UV shielding in TW while maintaining transmittance, bleached wood is impregnated with an ER/lignin combination to produce UV-shielding TW, which was compared with three glass-window types to demonstrate UV-shielding efficiency. The results show that a 12 mm thick glass door, double-layered glass windows, and 2 mm glass windows transmit significant UV radiation (220–250 µW/cm2, 260–270 µW/cm2, and 810–820 µW/cm2, respectively). In contrast, ER-TW and ER/lignin-TW provide 80–99% and 100% UV-shielding, respectively, across all UV-radiation regions. A 2-mm-thick ER-TW and ER/lignin–TW demonstrated excellent potential for UV-shielding window applications compared to regular glass windows.
Size and build strategy effects for the L-PBF process applied to Inconel 625 vertical struts: a combined numerical and experimental approach
Authors: Peyre Patrice , Silva Julien Rodrigues Da , Hamouche Zehoua , Helbert Anne-Laure , Daligault Julien , Dal Morgan , Coste Frédéric , Baudin Thierry 
Published: January 2024

Abstract

A combined numerical and experimental analysis of melt-pool dimensions and resulting solidification conditions was carried out on small laser powder bed fusion (L-PBF) struts (0.2 mm to 2 mm diameters), considered as single constitutive parts of the structure lattice. In the beginning, the high-speed imaging monitoring of melt pools was performed on a dedicated instrumented L-PBF set-up for various scan strategies. In the subsequent stage, a numerical thermal model was employed on COMSOL Multiphysics® to determine the alteration of the melt pool by the struts' diameter and scanning strategy for constant (power, scan speed) conditions. A good agreement was obtained between experimental and numerical melt-pool areas. This allowed validation of calculated local cooling rates and thermal gradients near the solidification front. A clear difference was shown between outside-in or inside-out strategies, and contour-hatching in terms of local solidification conditions. Higher cooling rates were obtained for outside-in conditions, especially near the external part of struts whereas inside-out conditions promoted more uniform cooling rates and thermal gradients. Moreover, a reduction of strut diameter induced the formation of a single melt-pool on the full strut’s surface, which promoted lower and more uniform cooling rates and a highly textured built material. A fairly good agreement was found between simulated thermal data and local microstructure development at the scale of solidification cells. Finally, the current work provides a deeper understanding on size and L-PBF strategy versus microstructure formation, and allows adapting build conditions on strut diameters.
Hybrid Fuzzy testing method based on decision Tree
Authors: jingus Jaydar , Shu Fei , Zhu Yayun , Li Zhongwei 
Published: January 2024

Abstract
The traditional fuzzy testing has insufficient code coverage for the target program testing, low directivity to the key code and low mining efficiency. In order to solve the above problems, a method of selecting symbol execution and Fuzzing testing based on decision tree is proposed in this paper. By collecting the indexes reflecting fuzzy test and symbol execution in a fixed time window, as the input of generating decision tree, and using the classification results of decision tree, automatic scheduling of fuzzy test and symbol test in vulnerability mining is realized. That is, the path set suitable for the fuzzy test (or symbol execution) is determined before the vulnerability detection begins, so as to guide the fuzzy test (or symbol execution) to the area suitable for them. At the same time, a path simplification and deduplication algorithm is proposed to improve the efficiency of vulnerability mining. The experimental results show that the proposed method significantly improves the coverage, efficiency and vulnerability mining ability of fuzzy testing compared with single symbol execution or fuzzy testing.
Bifurcation and stability analysis of a railway wheelset with active yaw control
Authors: Guo Peng , Shi Huailong , Huang Caihong , Cao Hongjun , Zeng Jing 
Published: January 2024

Abstract

This paper investigates the bifurcation characteristics of a railway wheelset under active yaw control to evaluate the control laws for hunting motion. The creep forces between wheels and rail expressed as nonlinear functions of creepages are further modified. The piecewise exponent model handled by regularization method can accurately simulate the flange force. The control force provided by actuators is represented as a nonlinear function of state variables, including primary terms, quadratic terms and cubic terms. At first, the increase of linear control gains can observably increase the speeds of Hopf bifurcation and limit point of cycle bifurcation and reduce the limit cycle amplitude. The subcritical Hopf bifurcation can be transformed into supercritical by the linear control gains. The effect of displacement and velocity control gains on hunting frequency is opposite. Secondly, the limit point of cycle bifurcation speed can be remarkably affected by the quadratic nonlinear control gains. The quadratic terms can maintain the Hopf bifurcation speed constant. Only one term can achieve the transition of Hopf bifurcation form. In particular, the quadratic term disrupts the symmetry of limit cycles and induces complex nonlinear behaviors such as period-doubling bifurcation. Thirdly, increasing the cubic nonlinear control gains can slightly increase the limit point of cycle bifurcation speed and change the Hopf bifurcation type. The Hopf bifurcation speed is not affected by the cubic terms. Notably, there is a significant discrepancy in the order of magnitude required for control gains to reduce the control force and limit cycle amplitude. Finally, the combination control of linear and cubic nonlinear gains can noticeably increase the Hopf bifurcation speed while reducing the limit cycle amplitude. Hence, the reasonable combination control of linear and cubic nonlinear gains is extremely helpful to maintain the hunting stability.
Return to work and psychosocial trajectories after breast cancer: a longitudinal and sequential approach
Authors: Rubion Elise , Bourdon Marianne , Sébille Véronique , Blanchin Myriam , Bertin Mélanie 
Published: January 2024

Abstract

Purpose
We aimed to describe the psychosocial adjustments according to return-to-work (RTW) trajectories in breast cancer survivors (BCS) using a sequential and temporal approach.
Methods
We used BCS data included from February 2015 to April 2016 in the Longitudinal Study on Behavioural, Economic and Sociological Changes after Cancer (ELCCA) cohort. RTW trajectories were identified using the sequence analysis method followed by a clustering. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale and the EORTC quality of life questionnaire was used at inclusion and all follow-up visits to assess Health-Related Quality of Life (HRQoL).
Results
Fifty-two BCS were included in the study among whom four clusters of RTW trajectories were identified and labelled: slow RTW (N = 10), quick RTW (N = 27), partial RTW (N = 8) and part-time work (N = 7). Quick and slow RTW clusters showed slightly lower baseline mean levels of anxiety and higher levels of HRQoL. In the 4 years following diagnosis, BCS in the quick RTW cluster tended to report higher HRQoL in terms of functioning and less symptoms of pain and fatigue while those in the partial RTW cluster showed a lower HRQoL on almost all dimensions. All clusters showed an increase in pain and fatigue symptoms until 6 months followed by a tendency to recover baseline levels.
Conclusions
The results of this study suggest that BCS who return to full-time work (slow and quick RTW patterns) recover better than patients who return to part-time work (partial and part-time RTW patterns).
Transcriptome analysis reveals multiple targets of erythritol-related transcription factor EUF1 in unconventional yeast Yarrowia lipolytica
Authors: Rzechonek Dorota Alicja , Szczepańczyk Mateusz , Borodina Irina , Neuvéglise Cecile , Mirończuk Aleksandra Maria 
Published: January 2024

Abstract
Background
Erythritol is a four-carbon polyol with an unclear role in metabolism of some unconventional yeasts. Its production has been linked to the osmotic stress response, but the mechanism of stress protection remains unclear. Additionally, erythritol can be used as a carbon source. In the yeast Yarrowia lipolytica, its assimilation is activated by the transcription factor Euf1. The study investigates whether this factor can link erythritol to other processes in the cell.
Results
The research was performed on two closely related strains of Y. lipolytica: MK1 and K1, where strain K1 has no functional Euf1. Cultures were carried out in erythrol-containing and erythrol-free media. Transcriptome analysis revealed the effect of Euf1 on the regulation of more than 150 genes. Some of these could be easily connected with different aspects of erythritol assimilation, such as: utilization pathway, a new potential isoform of transketolase, or polyol transporters. However, many of the upregulated genes have never been linked to metabolism of erythritol. The most prominent examples are the degradation pathway of branched-chain amino acids and the glyoxylate cycle. The high transcription of genes affected by Euf1 is still dependent on the erythritol concentration in the medium. Moreover, almost all up-regulated genes have an ATGCA motif in the promoter sequence.
Conclusions
These findings are particularly relevant given the increasing use of erythritol-induced promoters in genetic engineering of Y. lipolytica. Moreover, use of this yeast in biotechnological processes often takes place under osmotic stress conditions. Erythritol might be produce as a by-product, thus better understanding of its influence on cell metabolism could facilitate processes optimization.
Research status and development trends of post-myocardial infarction heart failure: a bibliometric analysis from 2012 to 2022
Authors: Hou Chengzhi , Wang Jie , He Haoqiang , Liu Chao , Chen Cong , Huang Xuanchun , Jiang Zhilin , Cheng Jiawen 
Published: January 2024

Abstract
Objective: Post-myocardial infarction heart failure (post-MI HF) is a prevalent cardiovascular disease. The study aims to preliminarily explore the current research status and development trends in the field of post-MI HF, providing reference ideas and methods for clinical and scientific research.
Methods: Publications related to post-MI HF from 2012-2022 in the Web of Science Core Collection's SCI-expanded dataset were extracted. Bibliometric analysis was executed using VOSviewer and R-bibliometrix, encompassing the number of publications, countries, institutions, authors, journals, cited references, and keywords.
Results: Within the last decade, 10,929 publications in the domain were published, involving 58,357 authors from 10,437 research institutions across 120 different countries and regions. These findings appeared in 1,446 distinct journals. The United States led in the number of publications, with Harvard Medical School being the most active institution and Kober, Lars from the University of Copenhagen, Denmark, as the leading author. Plos One was the most prolific journal, while Circulationhad the highest citation count. Over the past decade, research hotspots mainly centered on mortality, cardiac remodeling, and prognosis. In the recent two years, emphasis shifted to topics such as mendelian randomization, dapagliflozin, sacubitril/valsartan, COVID-19, and machine learning.
Conclusion: The study reveals the overall performance of publications in the post-MI HF research field. The clinical prognosis of patients and cardiac remodeling have been research hotspots over the past decade, yet mortality and readmission remain urgent clinical challenges. Future research trends in this field may revolve around the mechanisms of cardiac remodeling, apoptosis, and inflammation, as well as clinical prognosis studies on patient mortality rates. Additionally, echocardiography and cardiac magnetic resonance technology are gradually becoming important methods for evaluating drug efficacy and elucidating related mechanisms.
Ångstrom-scale gold particles loaded with alendronate via alpha- lipoic acid alleviate bone loss in osteoporotic mice
Authors: Gao Weihang , Li Jiao Jiao , Shi Jingyu , Lan Hongbing , Guo Yuanyuan , Fu Dehao 
Published: January 2024

Abstract

Osteoporosis is a highly prevalent metabolic disease characterized by low systemic bone mass and deterioration of bone microarchitecture, resulting in reduced bone strength and increased fracture risk. Current treatment options for osteoporosis are limited by factors such as efficacy, cost, availability, side effects, and acceptability to patients. Gold nanoparticles show promise as an emerging osteoporosis therapy due to their osteogenic effects and ability to allow therapeutic delivery but have inherent constraints, such as low specificity and the potential for heavy metal accumulation in the body. This study reports the synthesis of ultrasmall gold particles almost reaching the Ångstrom (Ång) dimension. The antioxidant alpha-lipoic acid (LA) is used as a dispersant and stabilizer to coat Ångstrom-scale gold particles (AuÅPs). Alendronate (AL), an amino-bisphosphonate commonly used in drug therapy for osteoporosis, is conjugated through LA to the surface of AuÅPs, allowing targeted delivery to bone and enhancing antiresorptive therapeutic effects. In this study, alendronate-loaded Ångstrom-scale gold particles (AuÅPs-AL) were used for the first time to promote osteogenesis and alleviate bone loss through regulation of the WNT signaling pathway, as shown through in vitro tests. The in vivo therapeutic effects of AuÅPs-AL were demonstrated in an established osteoporosis mouse model. Microcomputed tomography, histology, and tartrate-resistant acid phosphatase staining indicated that AuÅPs-AL significantly improved bone density and prevented bone loss, with no evidence of nanoparticle-associated toxicity. These findings suggest the possible future application of AuÅPs-AL in osteoporosis therapy and point to the potential of developing new approaches for treating metabolic bone diseases using Ångstrom-scale gold particles.