bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gram negative periprosthetic hip infection: nearly 25% same pathogen infection persistence at a mean of 2 years
Authors: Karczewski Daniel , Scholz Johann , Hipfl Christian , Akgün Doruk , Gonzalez Marcos R. , Hardt Sebastian 
Published: November 2023

Abstract
Purpose
While gram negative (GN) periprosthetic joint infections (PJI) have previously been described as difficult to treat pathogens with high rates of reinfection, limited investigations have addressed midterm outcomes and risk of infection persistence by the same pathogen. This study analyzed (1) baseline demographics, treatment strategy, and midterm outcomes of GN PJIs, as well as (2) differences in reinfection and relapse rates compared to gram positive (GP) PJIs.

Methods
We identified 29 patients that were revised for 30 GN PJIs of total hip arthroplasties (THAs) between 2010 and 2020 using a university-based hip registry. Mean age was 77 years, 63% were females (19), and mean BMI was 27 kg/m2. Major causative pathogens included Escherichia coli (12), Klebsiella pneumoniae (5), Pseudomonas aeruginosa (5), and Enterobacter cloacae complex (5). Mean follow-up was 3.5 years. Study outcomes included (1) Kaplan–Meier survivorship analyses of all 30 GN PJIs, and (2) comparison of 18 two-stage exchanges for GN PJIs and 104 two-stage exchanges for GP PJIs, performed during the time from 2013 to 2017.

Results
(1) The 5-year survivorship free of recurrent PJI was 69%, and there were 7 recurrent PJIs at a mean of 2 years. There were 2 further suprafascial wound infections, resulting in a 61% survivorship free of any infection at 5-years. At a mean of 2 years, there were 7 patients with reinfection by the same GN pathogen (6 PJIs, one wound infection) as at index revision (23%). (2) Following two-stage exchange, the 5-year survivorship free of recurrent PJI (GN: 74%; GP: 91%; p = 0.072), any infection (GN: 61%; GP: 91%; p = 0.001), and reinfection by the same pathogen was significantly lower among GN PJIs (GN: 73%; GP: 98%; p < 0.001).

Conclusions
Patients revised for GN PJIs are at increased risk of reinfection as opposed to GP infections. Affected patients must be counseled on the exceptionally high risk of infection persistence with one in four developing relapses.

Level of evidence
Therapeutic Level III.
The influence of implant position and of prosthetic characteristics on the occurrence of peri-implantitis: a retrospective study on periapical radiographs
Authors: Corbella Stefano , Morandi Benedetta , Calciolari Elena , Alberti Alice , Francetti Luca , Donos Nikolaos 
Published: November 2023

Abstract
Objective
The present retrospective study aimed to investigate the influence of malposition on the occurrence of peri-implantitis.

Materials and methods
The study included clinical records of systemically healthy patients with single and partial implant-supported rehabilitations and at least 1-year post-loading follow-up. The parameters collected included implant-related factors, patient-related factors, site-related factors, and prosthesis-related factors. The radiographic measurements were taken by using a dedicated software and the diagnosis of peri-implantitis was made based on all the available clinical and radiographic data. Descriptive statistics were provided for all variables. Following an exploratory approach, an implant-level analysis of factors influencing the occurrence of peri-implantitis was done through a multilevel multivariate logistic regression (mixed).

Results
A total of 180 implants belonging to 90 subjects were randomly selected. Malposition showed no statistically significant association with the occurrence of peri-implantitis. According to the multi-level analysis, the parameters that were significantly associated with peri-implantitis included presence / history of periodontitis (OR = 5.945, 95% CI: 1.093 – 32.334, P = 0.039) and presence of an emergence profile angle ≥ 45° (OR = 9.094, 95% CI: 2.017 – 40.995, P = 0.005).

Conclusions
Implant malposition, as defined following Buser’s criteria (2004), did not influence the occurrence of peri-implantitis in the selected cohort. Conversely, history of periodontitis and presence of a prosthetic emergence profile with an angle ≥ 45° were correlated to an increased risk of peri-implantitis.
Tenapanor for peritoneal dialysis patients with hyperphosphatemia: a phase 3 trial
Authors: Nakayama Masaaki , Kobayashi Shuhei , Kusakabe Miho , Ohara Meiko , Nakanishi Kaoru , Akizawa Tadao , Fukagawa Masafumi 
Published: November 2023

Abstract
Background
Tenapanor is a novel selective inhibitor of intestinal sodium/hydrogen exchanger 3 transporter. This is the first trial to assess the efficacy and safety of tenapanor in Japanese patients with hyperphosphatemia who are undergoing peritoneal dialysis.

Methods
This phase 3, open-label, multicenter, single-arm clinical trial targeted patients whose serum phosphorus was within 3.5–7.0 mg/dL with phosphate binders at screening. After phosphate binder washout, tenapanor was orally administered twice-daily, stepwise from 5 to 30 mg/dose for 16 weeks. The primary endpoint, mean change in serum phosphorus level, was evaluated at week 8. The 16-week treatment period was completed with tenapanor alone, and only one phosphate binder type was allowed for combined use after the primary endpoint.

Results
Of the 54 patients enrolled, 34 completed the study. At week 8, the primary endpoint, mean change in serum phosphorus level (last observation carried forward), was − 1.18 mg/dL (95% confidence interval: − 1.54, − 0.81 mg/dL) with tenapanor. From a baseline value of 7.65 mg/dL, serum phosphorus decreased to 6.14 and 5.44 mg/dL at weeks 8 and 16, respectively, and 46.3% and 76.5% of patients achieved serum phosphorus within 3.5–6.0 mg/dL at week 8 and week 16, respectively. The most common adverse event, diarrhea, occurred in 74.1% of patients; the severity of diarrhea was mild or moderate. Thus, the discontinuation percentage due to diarrhea was low at 5.6%.

Conclusions
Administration of tenapanor resulted in a sufficient reduction in serum phosphorus level at week 8 and was considered safe and tolerable.

Trial registration
NCT04766385.
Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions
Authors: Ishikawa Takuya , Yamao Kentaro , Mizutani Yasuyuki , Iida Tadashi , Kawashima Hiroki 
Published: November 2023

AbstractThis article provides an extensive review of the advancements and future perspectives related to endoscopic ultrasound-guided tissue acquisition (EUS-TA) for the diagnosis of solid pancreatic lesions (SPLs). EUS-TA, including fine-needle aspiration (EUS-FNA) and fine-needle biopsy (EUS-FNB), has revolutionized the collection of specimens from intra-abdominal organs, including the pancreas. Improvements in the design of needles, collection methods, and specimen processing techniques have improved the diagnostic performance. This review highlights the latest findings regarding needle evolution, actuation number, sampling methods, specimen evaluation techniques, application of artificial intelligence (AI) for diagnostic purposes, and use of comprehensive genomic profiling (CGP). It acknowledges the rising use of Franseen and fork-tip needles for EUS-FNB and emphasizes that the optimal number of actuations requires further study. Methods such as the door-knocking and fanning techniques have shown promise for increasing diagnostic performance. Macroscopic on-site evaluation (MOSE) is presented as a practical rapid specimen evaluation method, and the integration of AI is identified as a potentially impactful development. The study also underscores the importance of optimal sampling for CGP, which can enhance the precision of cancer treatment. Ongoing research and technological innovations will further improve the accuracy and efficacy of EUS-TA.
Joint Developmental Trajectories of Conduct Problems and Hyperactivity/Inattention: Antecedent Risk Markers for Group Membership
Authors: Ross Hannah Mercedes Araminta , Girard Lisa-Christine 
Published: November 2023

AbstractThis study investigated joint trajectories of conduct problems and hyperactivity/inattention from age three to nine in a cohort of 7,507 children in Ireland (50.3% males; 84.9% Irish). The parent-reported Strengths and Difficulties Questionnaire was used to collect information on conduct problems (CP) and hyperactivity/inattention (HI). Information regarding risk markers was collected when participants were nine-months-old via parent report and standardised assessments. Using a person-centred approach (i.e., group-based multi trajectory modelling), six trajectories were identified: no CP/low HI, low-stable CP/HI, low-declining CP/stable HI, desisting co-occurring CP/HI, pure-increasing HI, and high chronic co-occurring CP/HI. Specific risk markers for group membership included: male sex; birth complications; perceived difficult temperament; lower primary caregiver age and education level, and higher stress level; prenatal exposure to smoking, and indicators of lower socioeconomic status. Primary caregiver-child bonding and having siblings were protective markers against membership in elevated groups. Results suggest support for both ‘pure’ HI and co-occurring trajectories of CP and HI emerging in toddlerhood. However, no support was found for a ‘pure’ CP trajectory, which may support the suggestion that children on a persistent CP trajectory will have coexisting HI. Intervention efforts may benefit from starting early in life and targeting multiple risk markers in families with fewer resources.
Cold atmospheric plasma: a sustainable approach to inactivating viruses, bacteria, and protozoa with remediation of organic pollutants in river water and wastewater
Authors: Hamza Ibrahim Ahmed , El-Kalliny Amer S. , Abd‑Elmaksoud Sherif , Marouf Mohamed A. , Abdel‑Wahed Mahmoud S. , El-Liethy Mohamed Azab , Hefny Mohamed Mokhtar 
Published: November 2023

AbstractInnovative technologies are needed to enhance access to clean water and avoid waterborne diseases. We investigated the performance of cold atmospheric plasma (CAP), a clean and sustainable approach for microbial inactivation and total organic carbon (TOC) degradation in environmental water. Water matrices played a crucial role in the performance of CAP efficacy; for example, complete removal of ɸX174 from dH2O required 1 min of treatment, while ɸX174 reductions of ~ 2log10 and 4log10 were obtained after 10 min of CAP exposure in river water and wastewater samples, respectively. Similarly, after 10 min of CAP treatment, bacterial concentrations decreased by 3 log10 and 4 log10, in river and wastewater samples, respectively. In contrast, after 30 s of contact time, a 4 log10 reduction of bacteria was accomplished in dH2O. Complete removal of Acanthamoeba from dH2O was found after 30 min of CAP treatment, whereas it was not removed from surface water or wastewater at the same exposure time. Additionally, the approach successfully reduced TOC, and the degradation kinetics of TOC were represented by pseudo-first-order. CAP showed higher rates of TOC degradation in the final effluent of the wastewater treatment plant compared to surface water. The difference in CAP performance between river water and wastewater could be attributed to the bulk structure of humic acids in river water compared to small organic byproducts in the final effluent of WWTP. Overall, the findings reported here support the idea that CAP holds promise as a sustainable solution for controlling pathogens, removing organic water pollution, and integrating with traditional purification processes. Low-cost systems may advance CAP technology and increase its widespread use.
Gadolinium accumulation and its biochemical effects in Mytilus galloprovincialis under a scenario of global warming
Authors: Andrade Madalena , Soares Amadeu M. V. M. , Solé Montserrat , Pereira Eduarda , Freitas Rosa 
Published: November 2023

AbstractElectrical and electronic equipment reaching the end of its useful life is currently being disposed of at such an alarmingly high pace that raises environmental concerns. Together with other potentially dangerous compounds, electronic waste contains the rare-earth element gadolinium (Gd), which has already been reported in aquatic systems. Additionally, the vulnerability of aquatic species to this element may also be modified when climate change related factors, like increase in temperature, are taken into consideration. Thus, the present study aimed to evaluate the toxicity of Gd under a scenario of increased temperature in Mytilus galloprovincialis mussels. A multi-biomarker approach and Gd bioaccumulation were assessed in mussels exposed for 28 days to 0 and 10 μg/L of Gd at two temperatures (control – 17 °C; increased – 22 °C). Results confirmed that temperature had a strong influence on the bioaccumulation of Gd. Moreover, mussels exposed to Gd alone reduced their metabolism, possibly to prevent further accumulation, and despite catalase and glutathione S-transferases were activated, cellular damage seen as increased lipid peroxidation was not avoided. Under enhanced temperature, cellular damage in Gd-exposed mussels was even greater, as defense mechanisms were not activated, possibly due to heat stress. In fact, with increased temperature alone, organisms experienced a general metabolic depression, particularly evidenced in defense enzymes, similar to the results obtained under Gd-exposure. Overall, this study underlines the importance of conducting environmental risk assessment taking into consideration anticipated climate change scenarios and exposures to emerging contaminants at relevant environmental concentrations.
Tricky Truths: How Should Alethic Pluralism Accommodate Racial Truths?
Authors: van der Merwe Ragnar , Msimang Phila 
Published: November 2023

AbstractSome alethic pluralists maintain that there are two kinds of truths operant in our alethic discourse: a realist kind and an anti-realist kind. In this paper, we argue that such a binary conception cannot accommodate certain social truths, specifically truths about race. Most alethic pluralists surprisingly overlook the status of racial truths. Douglas Edwards is, however, an exception. In his version of alethic pluralism—Determination Pluralism—racial truths are superassertible (anti-realist) true rather than correspondence (realist) true. We argue that racial truths exhibit features of both superassertibility (anti-realism) and correspondence (realism). This suggests a fuzzy boundary between realist and anti-realist kinds of truth. There may be a continuum rather than a dichotomy of truths. We conclude by sketching one way for alethic pluralists to accommodate such a notion.
Exploring the emotional and thematic matrix of dreams during war: the role of anxiety and depression
Authors: Kaźmierczak Izabela , Zajenkowska Anna , Bodecka-Zych Marta , Jasielska Dorota , Olechowska Anna , Molińska Weronika , Moniuszko Karolina 
Published: November 2023

AbstractDreams serve as a psychological space where the human mind grapples with burdensome issues, and war undoubtedly falls into that category. Inspired by Charlotte Beradt’s work on analyzing dreams during the Third Reich, we collected dreams from a sample of Polish individuals (N = 90) during the outbreak of war in March 2022. Our objective was to identify the most intense emotions conveyed through these dreams and investigate differences in both emotional intensity and dream content between individuals with high levels of anxiety and closely related depression, and those with lower levels of anxiety. We employed a mixed-method study design. The prevailing emotions observed in the dreams were surprise, fear, and sadness. Interestingly, the dreams of participants with higher levels of anxiety exhibited less surprise compared to the comparison group. Additionally, we found that dreams reported by individuals with higher levels of depression conveyed a greater sense of sadness than those in the comparison group. Content analysis revealed that anxious individuals’ dreams prominently featured horror, which evoked feelings of powerlessness rather than surprise. In contrast, the dreams of non-anxious individuals exhibited a dynamic narrative with numerous twists and turns, creating a simultaneous presence and absence of threats. Consequently, the resulting vagueness and uncertainty likely contributed to the element of surprise.
Stability of the Quermassintegral Inequalities in Hyperbolic Space
Authors: Sahjwani Prachi , Scheuer Julian 
Published: November 2023

AbstractFor the quermassintegral inequalities of horospherically convex hypersurfaces in the$$(n+1)$$(n+1)-dimensional hyperbolic space, where$$n\ge 2$$n≥2, we prove a stability estimate relating the Hausdorff distance to a geodesic sphere by the deficit in the quermassintegral inequality. The exponent of the deficit is explicitly given and does not depend on the dimension. The estimate is valid in the class of domains with upper and lower bound on the inradius and an upper bound on a curvature quotient. This is achieved by some new initial value-independent curvature estimates for locally constrained flows of inverse type.
An efficient 3D cell-based discrete fracture-matrix flow model for digitally captured fracture networks
Authors: Sun Lei , Li Mei , Abdelaziz Aly , Tang Xuhai , Liu Quansheng , Grasselli Giovanni 
Published: November 2023

AbstractComplex hydraulic fracture networks are critical for enhancing permeability in unconventional reservoirs and mining industries. However, accurately simulating the fluid flow in realistic fracture networks (compared to the statistical fracture networks) is still challenging due to the fracture complexity and computational burden. This work proposes a simple yet efficient numerical framework for the flow simulation in fractured porous media obtained by 3D high-resolution images, aiming at both computational accuracy and efficiency. The fractured rock with complex fracture geometries is numerically constructed with a cell-based discrete fracture-matrix model (DFM) having implicit fracture apertures. The flow in the complex fractured porous media (including matrix flow, fracture flow, as well as exchange flow) is simulated with a pipe-based cell-centered finite volume method. The performance of this model is validated against analytical/numerical solutions. Then a lab-scale true triaxial hydraulically fractured shale sample is reconstructed, and the fluid flow in this realistic fracture network is simulated. Results suggest that the proposed method achieves a good balance between computational efficiency and accuracy. The complex fracture networks control the fluid flow process, and the opened natural fractures behave as primary fluid pathways. Heterogeneous and anisotropic features of fluid flow are well captured with the present model.
Molecular characterization of Newcastle disease virus obtained from Mawenzi live bird market in Morogoro, Tanzania in 2020–2021
Authors: Tsaxra John B. , Abolnik Celia , Kelly Terra R. , Chengula Augustino A. , Mushi James R. , Msoffe Peter L. M. , Muhairwa Amandus P. , Phiri Thandeka , Jude Rachel , Chouicha Nadira , Mollel Esther L. , Zhou Huaijun , Gallardo Rodrigo A. 
Published: November 2023

AbstractNewcastle disease (ND) is among the most important poultry diseases worldwide. It is the major threat to poultry production in Africa and causes major economic losses for both local and commercial chickens. To date, half of ND class II genotypes have been reported in Africa (I, IV, V, VI, VII, XI, XIII, XIV, XVII, XVIII, and XXI). The information on the circulating NDV genotypes is still scarce despite the endemic nature of ND in most countries on the African continent.A total of 659 oro-cloacal swabs were collected from local chickens in Mawenzi live bird market located in Morogoro, Tanzania, between June 2020 and May 2021. Newcastle disease virus was detected by using reverse transcription real-time polymerase chain reaction (RT-qPCR) and conventional PCR followed by sequencing of PCR products. The prevalence of NDV in the surveilled live bird markets was 23.5%. Sequencing and phylogenetic analysis revealed the presence of sub-genotype VII.2. The detected sub-genotype VII.2 has phylogenetic links to Zambian NDV strains implying a Southeast dissemination of the virus, considering that it was first detected in Mozambique. This study underscores the need of active NDV surveillance to determine the distribution of this NDV genotype in the country and monitor its spread and contribution to the emergence of new ND viruses.
Using Bayesian Dynamic Borrowing to Maximize the Use of Existing Data: A Case-Study
Authors: Edwards Dawn , Best N. , Crawford J. , Zi L. , Shelton C. , Fowler A. 
Published: November 2023

AbstractBayesian Dynamic Borrowing (BDB) designs are being increasingly used in clinical drug development. These methods offer a mathematically rigorous and robust approach to increase efficiency and strengthen evidence by integrating existing trial data into a new clinical trial. The regulatory acceptability of BDB is evolving and varies between and within regulatory agencies. This paper describes how BDB can be used to design a new randomised clinical trial including external data to supplement the planned sample size and discusses key considerations related to data re-use and BDB in drug development programs. A case-study illustrating the planning and evaluation of a BDB approach to support registration of a new medicine with the Center for Drug Evaluation in China will be presented. Key steps and considerations for the use of BDB will be discussed and evaluated, including how to decide whether it is appropriate to borrow external data, which external data can be re-used, the weight to put on the external data and how to decide if the new study has successfully demonstrated treatment benefit.
Seismic Imaging of the Westward Transition From Yakutat to Pacific Subduction in Southern Alaska
Authors: Millet Florian , Rondenay Stéphane , Bodin Thomas , Tape Carl 
Published: November 2023

AbstractAlaska is located at the northernmost point of the interface between the Pacific plate and the North American continent. The subduction of the Pacific plate generates arc volcanoes along the Aleutian trench, which stops to the east at the Denali Volcanic Gap. This volcanic gap has been linked to the underthrusting of the Yakutat terrane, which might alter the thermal state of the mantle wedge and prevent melt formation. This implies that the limits of the volcanic activity should mirror the extent of the Yakutat subduction. However, the transition from the Pacific slab to the Yakutat terrane at depth is not fully understood. To investigate this issue, we processed a new composite seismic data set from six arrays deployed in the region from 2000 to 2018. We apply a multi‐mode 3D Kirchhoff migration to obtain high‐resolution 3D scattering images of the region. Our results highlight a sharp lateral boundary in the slab structure, with a 10 km Moho step, just offshore Anchorage, and a more gradual slab transition beneath the southern part of the Kenai peninsula. Our images from the Yakutat slab plunge down to 150 km depth are consistent with previous estimates of the Yakutat slab extent below the Alaska Range. Although the steeply dipping boundaries of the subducting Pacific lithospheres are not fully recovered, deep coherent signals from the Pacific slab are observed down to 150 km depth. These observations suggest that the crust is still partially uneclogitized at these depths in both slabs.