bluuebunny/crossref_metadata_2025_split huggingface dataset:
A numerical scheme based on the Taylor expansion and Lie product formula for the second‐order acoustic wave equation and its application in seismic migration
Authors: Araujo Edvaldo S. , Pestana Reynam C. 
Published: January 2024

AbstractWe have developed a numerical scheme for the second‐order acoustic wave equation based on the Lie product formula and Taylor‐series expansion. The scheme has been derived from the analytical solution of the wave equation and in the approximation of the time derivative for a wavefield. Through these two equations, we obtained the first‐order differential equation in time, where the time evolution operator of the analytic solution of this differential equation is written as a product of exponential matrices. The new numerical solution using a Lie product formula may be combined with Taylor‐series, Chebyshev, Hermite and Legendre polynomial expansion or any other expansion for the cosine function. We use the proposed scheme combined with the second‐ or fourth‐order Taylor approximations to propagate the wavefields in a recursive procedure, in a stable manner, accurately and efficiently with even larger time steps than the conventional finite‐difference method. Moreover, our numerical scheme has provided results with the same quality as the rapid expansion method but requiring fewer computations of the Laplacian operator per time step. The numerical results have shown that the proposed scheme is efficient and accurate in seismic modelling, reverse time migration and least‐squares reverse time migration.
‘Trying to stay afloat’: Education professionals' perspectives on the impact of the COVID‐19 pandemic on children with special educational needs and disabilities
Authors: Ashworth Emma , Bray Lucy , Alghrani Amel , Kirkby Joanna 
Published: January 2024

AbstractThis study aimed to investigate the experiences of education professionals in their efforts to provide education and support to children with special educational needs and disabilities (SEND) amid the COVID‐19 pandemic, and to gain insights into the perceived repercussions of pandemic‐related restrictions on the educational development and overall wellbeing of these children. Mixed‐methods surveys (N = 100) and semi‐structured qualitative interviews (N = 6) were utilised. Data were analysed using descriptive statistics and thematic analysis. Findings indicate substantial challenges faced by education professionals in delivering appropriate and effective education and well‐being support to children with SEND during periods of school ‘closures’, resulting in hindered academic progression and adverse impacts on the well‐being of children with SEND, their families and the education professionals themselves. It is vital that effective support strategies and appropriate training are implemented, in addition to further research to establish what would be most beneficial for all teachers, and particularly those supporting children with SEND.
Hospital outpatient department billing is a poor indicator of primary care practice integration with hospital systems
Authors: Chatrath Saumya , Rich Eugene C. , O'Malley Ann S. , Cohen Genna , Jones David J. 
Published: January 2024

AbstractObjectiveTo test the reliability of Medicare claims in measuring vertical integration. We assess the accuracy of a commonly used measure of integration, primary care physician (PCP) practices billing Medicare as a hospital outpatient department (HOPD) in claims.Data Sources and Study SettingMedicare fee‐for‐service claims, IQVIA, and CPC+ practice surveys for this study.Study DesignWe compare measures of integration from Medicare claims to self‐reported indicators of integration from IQVIA and a survey of CPC+ participating practice sites.Data Collection/Extraction MethodsWe measure integration by using site‐of‐service billing in the 100% sample of Medicare Carrier claims from 2017–2020. In the IQVIA SK&A (2017–2018), OneKey (2019–2020), and practice survey data (2017–2019), we use self‐reported responses to measure integration.Principal FindingsWe find that currently most PCP practices sites that report themselves as being integrated with a health system do not bill as an HOPD. In 2017, 11% of CPC+ practices were identified as being vertically integrated in claims, while the equivalent numbers in SK&A and surveys were 52% and 54% integration, respectively. A t‐test found that both datasets significantly differed from claims (Survey: 41.3%–45.1%; SK&A: 45.3%–51.1%); this gap persists in 2018–2019.ConclusionMeasuring physician‐hospital vertical integration accurately is integral to determining consolidation. The overwhelming majority of PCP practice sites not billing as an HOPD may reflect Medicare regulatory changes that have reduced the financial incentives for doing so. These findings have implications for researchers that study the growth in PCP‐hospital integration in health care markets.
Higher levels of state funding for Home‐ and Community‐Based Services linked to better state performances in Long‐Term Services and Supports
Authors: Cheng Zijing , Mutoniwase Espérance , Cai Xueya , Li Yue 
Published: January 2024

AbstractObjectiveTo examine the relationship between the level of state funding for Home‐ and Community‐Based Services (HCBS) and state overall and dimension‐specific performances in Long‐Term Services and Supports (LTSS).Data Sources and Study SettingWe employed state‐level secondary data from the Medicaid LTSS Annual Expenditures Reports, the American Association of Retired Persons (AARP) State Scorecards, the U.S. Census, and Federal Reserve Economic data, spanning the timeframe of 2010–2020.Study DesignOverall state LTSS rankings, along with dimension‐specific rankings, were modeled separately against state Medicaid spending on HCBS relative to total Medicaid spending on LTSS. All models were adjusted for state covariates, secular trend, and state fixed effects.Data Collection/Extraction MethodsThe study sample included all 50 states and the District of Columbia. However, California, Delaware, Illinois, and Virginia were excluded from FY2019 due to missing data on Medicaid HCBS expenditures.Principal FindingsEvery 10 percentage‐point increase in the proportion of Medicaid LTSS spending to HCBS demonstrated 2.05 points improvement (95% confidence interval [CI]: −3.88 to 0.22, p = 0.03) in rankings for state overall LTSS system performance, 2.92 points improvement (95% CI: −4.87 to 0.98, p < 0.01) in rankings for the Choice of Setting and Provider dimension, as well as 1.73 points (95% CI: −3.14 to 0.32, p = 0.02) ranking improvement in the dimension of Effective Transitions.ConclusionsOur study suggested promising effects of increased state funding for HCBS on LTSS performance.
Combining phylogeography and ecological niche modeling to infer the evolutionary history of the Cordoba vesper mouse (Calomys venustus)
Authors: PINOTTI Juan Diego , MARTIN María Laura , CHIAPPERO Marina Beatriz , ANDREO Verónica , GONZÁLEZ‐ITTIG Raúl Enrique 
Published: January 2024

AbstractThe evolutionary dynamics of the ecoregions of southern South America and the species that inhabit them have been poorly studied, and few biogeographic hypotheses have been proposed and tested. Quaternary climatic oscillations are among the most important processes that have led to the current distribution of genetic variation in different regions of the world. In this work, we studied the evolutionary history and distribution of the Córdoba vesper mouse (Calomys venustus), a characteristic rodent of the region of which little is known about its natural history. Since the population dynamics of this species are influenced by climatic factors, this rodent is a suitable model to study the effects of Quaternary climatic oscillations in central Argentina. The mitochondrial cytochrome b gene was sequenced to analyze the phylogeography of C. venustus, and ecological niche modeling tools were used to map its potential distributions. The results of these approaches were combined to provide additional spatially explicit information about this species' past. Our results suggest that the Espinal was the area of origin of this species, which expanded demographically and spatially during the last glacial period. A close relationship was found between the Espinal and the Mountain Chaco. These results are consistent with previous studies and emphasize the role of the Espinal in the biogeographic history of southern South America as an area of origin of several species.
Does Green Bond Issuance Enhance Market Return of Equity Shares in the Indian Stock Market?*
Authors: Kodiyatt Snehith Jacob , Nair Biju A V , Jacob Manna Sarah , Reddy Krishna 
Published: January 2024

AbstractThis study examines the announcement effect of a green bond on the issuer's stock returns in the Indian Stock Market. The event study methodology for data analysis and abnormal returns were calculated using the market model for the 16‐day event window that includes the 5 days prior and 10 days after the issuance of the green bonds. The findings of this study show that green bond announcements do not create any significant abnormal returns, thus suggesting investors' irrationality toward environmental factors. This study informs policymakers that investor education relating to the environment is needed in India.
A Legal Geography of Prison and Other Carceral Spaces
Authors: Bloch Stefano 
Published: January 2024

AbstractAs scholars apply the concept of “the carceral” to more and increasingly diffuse spaces of containment, displacement, and cordoning across free society, I call for a means by which “carcerality” is measured and understood as a productive force in the denial of constitutional rights and protections. I therefore provide a legal reading of carcerality, which establishes prisons as the sine qua non of the carceral landscape, preceded by an analysis of how the reliance on civil law, nuisance ordinances, and other methods of constitutional circumvention in the absence of criminal procedure works within the public sphere to punish residents residing within what Foucault called the carceral archipelago. Along the way I provide vignettes about my own experience with the legal and insidious forms of criminalisation and non‐criminal punishment that comprise the carceral continuum.
Knowledge of community pharmacists on infantile haemangioma: Gaps and lack confidence to deliver propranolol still need to be filled
Authors: Pottier Charline , Guichard Elie , Thomann Claire , Denevault‐Sabourin Caroline , Maruani Annabel , Leducq Sophie 
Published: January 2024

AbstractAimTo evaluate the knowledge, practices and self‐confidence of community pharmacists, pharmacy technicians and pharmacy students about infantile haemangioma (IH) and propranolol treatment.MethodsA national survey was conducted in France from May 2022 to October 2022. A 42‐item online questionnaire was used to assess pharmacists' knowledge of the epidemiology, clinical features and management of IH and propranolol treatment.ResultsThe survey included 255 participants. The mean age was 34.9 years (±9.0); 225 (88%) were women. In all, 193 (76%) practised in urban pharmacies. Altogether, 83 participants (33%) had delivered oral propranolol solution for IH in the last 6 months. Participants' median score for self‐confidence regarding propranolol dispensing was five (interquartile range, 2.5–6) on a scale of 1 to 10. Overall, 96 (38%) had more than 50% correct answers on the questionnaire. Multinomial regression models showed high scores on the questionnaire associated with high self‐confidence when delivering oral propranolol solution, low number of years since graduation and having already delivered propranolol treatment.ConclusionThis study highlights a lack of knowledge of IH and modalities of propranolol treatment by community pharmacists and slight self‐confidence when delivering propranolol. Greater cooperation between healthcare professionals could improve the proper use of medicine.
ECB monetary policy communication events: Do they move euro area yields?
Authors: Jurkšas Linas , Kaminskas Rokas , Vasiliauskaitė Deimantė 
Published: January 2024

AbstractThis study aims to determine and compare the impact of four different types of European Central Bank (ECB) monetary policy communication events on euro area sovereign yields on an intraday basis since 2014. Our paper distinguishes it from similar studies in that we analyze a broad range of ECB communication types. The results reveal that ECB decisions and press conferences have the most substantial intraday impact on normalized sovereign yields while the impact of speeches and accounts appears to be much weaker. Countries with the highest debt levels (such as Italy, Spain, and France) experienced the most robust changes in fiscal costs, while the period encompassing the economic shock induced by the Covid‐19 pandemic shows weaker effects.
Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells
Authors: Fukuoka Makoto , Kodama Takahiro , Murai Kazuhiro , Hikita Hayato , Sometani Emi , Sung Jihyun , Shimoda Akiyoshi , Shigeno Satoshi , Motooka Daisuke , Nishio Akira , Furuta Kunimaro , Tatsumi Tomohide , Yusa Kosuke , Takehara Tetsuo 
Published: January 2024

AbstractThere are approximately 250 million people chronically infected with hepatitis B virus (HBV) worldwide. Although HBV is often integrated into the host genome and promotes hepatocarcinogenesis, vulnerability of HBV integration in liver cancer cells has not been clarified. The aim of our study is to identify vulnerability factors for HBV‐associated hepatocarcinoma. Loss‐of‐function screening was undertaken in HepG2 and HBV‐integrated HepG2.2.15 cells expressing SpCas9 using a pooled genome‐wide clustered regularly interspaced short palindromic repeats (CRISPR) library. Genes whose guide RNA (gRNA) abundance significantly decreased in HepG2.2.15 cells but not in HepG2 cells were extracted using the MAGeCK algorithm. We identified four genes (BCL2L1, VPS37A, INSIG2, and CFLAR) that showed significant reductions of gRNA abundance and thus potentially involved in the vulnerability of HBV‐integrated cancer cells. Among them, siRNA‐mediated mRNA inhibition or CRISPR‐mediated genetic deletion of INSIG2 significantly impaired cell proliferation in HepG2.2.15 cells but not in HepG2 cells. Its inhibitory effect was alleviated by cotransfection of siRNAs targeting HBV. INSIG2 inhibition suppressed the pathways related to cell cycle and DNA replication, downregulated cyclin‐dependent kinase 2 (CDK2) levels, and delayed the G1‐to‐S transition in HepG2.2.15 cells. CDK2 inhibitor suppressed cell cycle progression in HepG2.2.15 cells and INSIG2 inhibition did not suppress cell proliferation in the presence of CDK2 inhibitor. In conclusion, INSIG2 inhibition induced cell cycle arrest in HBV‐integrated hepatoma cells in a CDK2‐dependent manner, and thus INSIG2 might be a vulnerability factor for HBV‐associated liver cancer.
Regulator of G protein signaling 1 is a potential target in gastric cancer and impacts tumor‐associated macrophages
Authors: Wu Mengting , Xu Xuefei , Yang Chuqi , An Qingwen , Zhang Jingcheng , Zhao Zhengqi , Feng Yewen , Liang Weiyu , Fu Yufei , Zhang Guangji , Jiang Tao 
Published: January 2024

AbstractRegulator of G protein signaling 1 (RGS1) is closely associated with the tumor immune microenvironment and is highly expressed in various tumors and immune cells. The specific effects of RGS1 in the dynamic progression from chronic gastritis to gastric cancer have not been reported, and the role of tumor‐associated macrophages (TAMs) is also unclear. In the present study, RGS1 was identified as an upregulated gene in different pathological stages ranging from chronic gastritis to gastric cancer by using Gene Expression Omnibus (GEO) screening together with pancancer analysis of The Cancer Genome Atlas and clinical prognostic analysis. The results indicated that RGS1 is highly expressed in gastric cancer and has potential prognostic value. We confirmed through in vivo experiments that RGS1 inhibited the proliferation of gastric cancer cells and promoted apoptosis, which was further corroborated by in vitro experiments. Additionally, RGS1 influenced cell migration and invasion. In our subsequent investigation of RGS1, we discovered its role in the immune response. Through analyses of single‐cell and GEO database data, we confirmed its involvement in immune cell regulation, specifically TAM activation. Subsequently, we conducted in vivo and in vitro experiments to confirm the involvement of RGS1 in polarizing M1 macrophages while indirectly regulating M2 macrophages through tumor cells. In conclusion, RGS1 could be a potential target for the transformation of chronic gastritis into gastric cancer and has a measurable impact on TAMs, which warrants further in‐depth research.
Durvalumab after chemoradiotherapy in non‐small cell lung cancer with EGFR mutation: A real‐world study (HOT2101)
Authors: Tsuji Kosuke , Mizugaki Hidenori , Yokoo Keiki , Kobayashi Maki , Kawashima Yosuke , Kimura Nozomu , Yokouchi Hiroshi , Kikuchi Hajime , Sumi Toshiyuki , Kawai Yasutaka , Kobashi Kenta , Morita Ryo , Ito Kenichiro , Kitamura Yasuo , Minemura Hiroyuki , Nakamura Keiichi , Aso Mari , Honjo Osamu , Tanaka Hisashi , Takashina Taichi , Tsurumi Kyoji , Sugisaka Jun , Tsukita Yoko , Konno Satoshi , Oizumi Satoshi 
Published: January 2024

AbstractDurvalumab has been administered to patients with unresectable stage III non‐small cell lung cancer (NSCLC). However, it remains unclear whether durvalumab benefits these patients with epidermal growth factor receptor (EGFR) mutation. We conducted a retrospective, multicenter study of patients with EGFR mutation who received chemoradiotherapy (CRT) between June 2018 and March 2021. We assessed patient characteristics, efficacy of durvalumab, and durvalumab safety before and after targeted therapy. We collected data on a total of 673 patients, of whom 401 (59.6%) underwent EGFR mutation testing. Fifty‐one patients were EGFR positive and 311 were EGFR negative. In the EGFR‐positive group, there were higher proportions of females, never‐smokers, and patients with adenocarcinoma histology. Of the 51 patients in the positive group and 311 in the negative group who received CRT, 45 (88.2%) and 247 (79.4%) received durvalumab, with median progression‐free survival of 23.0 and 24.2 months in the positive and negative groups, respectively (hazard ratio 1.03; 95% confidence interval: 0.64–1.67). The main adverse event was pneumonitis (positive group: 62.2%; 4.4% grade 3; negative group: 62.3%; 6.9% grade 3). No treatment‐related deaths were observed. Of the 45 patients in the positive group who received durvalumab, 14 (31.1%) received targeted therapy after durvalumab at the data cutoff. One patient discontinued targeted therapy after developing pneumonitis. In patients with unresectable stage III NSCLC with EGFR mutation, durvalumab after CRT is potentially safe and effective. This may be a suitable treatment sequence for these patients.
An engineered Accum‐E7 protein‐based vaccine with dual anti‐cervical cancer activity
Authors: Bikorimana Jean‐Pierre , Abusarah Jamilah , Gonçalves Marina , Farah Roudy , Saad Wael , Talbot Sebastien , Stanga Daniela , Beaudoin Simon , Plouffe Sebastien , Rafei Moutih 
Published: January 2024

AbstractWorldwide prevalence of cervical cancer decreased significantly with the use of human papilloma virus (HPV)‐targeted prophylactic vaccines. However, these multivalent antiviral vaccines are inert against established tumors, which leave patients with surgical ablative options possibly resulting in long‐term reproductive complications and morbidity. In an attempt to bypass this unmet medical need, we designed a new E7 protein‐based vaccine formulation using Accum™, a technology platform designed to promote endosome‐to‐cytosol escape as a means to enhance protein accumulation in target cells. Prophylactic vaccination of immunocompetent mice using the Accum‐E7 vaccine (aE7) leads to complete protection from cervical cancer despite multiple challenges conducted with ascending C3.43 cellular doses (0.5‐, 1.0‐, and 2.0 × 106 cells). Moreover, the humoral response induced by aE7 was higher in magnitude compared with naked E7 protein vaccination and displayed potent inhibitory effects on C3.43 proliferation in vitro. When administered therapeutically to animals with pre‐established C3.43 or Tal3 tumors, the vaccine‐induced response synergized with multiple immune checkpoint blockers (anti‐PD‐1, anti‐CTLA4, and anti‐CD47) to effectively control tumor growth. Mechanistically, the observed therapeutic effect requires cross‐presenting dendritic cells as well as CD8 T cells predominantly, with a non‐negligible role played by both CD4+ and CD19+ lymphocytes. good laboratory practice (GLP) studies revealed that aE7 is immunogenic and well tolerated by immunocompetent mice with no observed adverse effects despite the use of a fourfold exceeding dose. In a nutshell, aE7 represents an ideal vaccine candidate for further clinical development as it uses a single engineered protein capable of exhibiting both prophylactic and therapeutic activity.
Synthesis, molecular docking, QSTR and in‐silico ADME studies of novel 1,3‐thiazolidine‐amide derivatives as hybrid bioactive heterocycles
Authors: Pund Amit A. , Pansare Dattatraya N. , Sarkate Aniket P. , Deshpande Prathmesh P. , Magare Baban K. 
Published: January 2024

AbstractIn this article, we described synthesis of 1,3‐thiazolidine ‐ amide hybrid derivatives by two different methods from (S)‐2‐amino‐3‐(4‐(benzyloxy)phenyl)‐1‐(thiazolidin‐3‐yl)propan‐1‐one (4). In first method, catalytic amidation was carried out under microwave irradiation using Ceric Ammonium Nitrate (CAN) as a green catalyst where as in second conventional method; CDI was used as a significant coupling reagent to optimize reaction condition and yield of product. All new compounds were well characterized by 1H NMR, 13C NMR, IR and ESMS spectral techniques and evaluated in vitro antibacterial and antifungal activity. The molecular docking study revealed that the designed compounds snuggly fit in the active site of 4WMZ protein. In addition, the QSTR study of new compounds were carried out with the help of Toxicity Estimation Software Tool (T.E.S.T). The results showed slight toxic nature of new compounds. In‐silico ADME studies significant values of pharmacokinetic parameters and demonstrated good drug like characteristics based on Lipinski's rule of five.