bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐PD‐1 immunotherapy with adjuvant ablative fractional laser displays increased tumour clearance of squamous cell carcinoma, a murine study
Authors: Christensen Rikke Louise , Wiinberg Martin , Lerche Catharina Margrethe , Demehri Shadmehr , Olesen Uffe Høgh , Haedersdal Merete 
Published: February 2024

AbstractPD‐1 checkpoint inhibitors are used as systemic immunotherapy for locally advanced and metastatic cutaneous squamous cell carcinoma (SCC); however, improved treatment efficacy is urgently needed. In this study, we aimed to investigate the effect of combining systemic anti‐PD‐1 treatment with adjuvant ablative fractional laser (AFL) in a spontaneous SCC mouse model. Tumours induced by ultraviolet radiation in the strain C3.Cg‐Hrhr/TifBomTac were divided into four groups: anti‐PD‐1‐antibody+AFL (n = 33), AFL alone (n = 22) anti‐PD‐1‐antibody alone (n = 31) and untreated controls (n = 46). AFL was given at Day 0 (100 mJ/mb, 5% density), while anti‐PD‐1‐antibody (ip, 200 μg) at Days 0, 2, 4, 6 and 8. Response to treatment was evaluated by tumour growth, survival time and by dividing response to treatment into complete responders (clinically cleared tumours), partial responders (reduced tumour growth rate compared to untreated controls) and non‐responders (no decrease in tumour growth rate compared to untreated controls). The strongest tumour response was observed following the combination of systemic anti‐PD‐1 treatment combined with laser exposure, resulting in the highest percentage of complete responders (24%) compared with untreated controls (0%, p < 0.01), AFL monotherapy (13%, p > 0.05) and anti‐PD‐1‐antibody monotherapy (3%, p > 0.05). Moreover, all three treatment interventions demonstrated significantly reduced tumour growth rates compared with untreated controls (p < 0.01), and the mice had significantly longer survival times (p < 0.01). In conclusion, the combination treatment revealed an improved treatment effect that significantly enhanced the complete tumour clearance not observed with the monotherapies, indicating a possible additive effect of anti‐PD‐1 with adjuvant AFL in treatment of SCC.
Increased neutrophil‐derived IL‐17A identified in generalized pustular psoriasis
Authors: Lan Yu , Wu Xiaoyan , Zhong Xinyu , Song Pengfei , Liu Leying , Liu Yuhua , Ai Xuechen , Han Changxu , Zhang Zhenying 
Published: February 2024

AbstractGeneralized pustular psoriasis (GPP) is considered to be a distinct clinical entity from psoriasis vulgaris (PV), with different clinical and histological manifestations. The pathogenesis of GPP has not been thoroughly elucidated, especially in those patients lacking interleukin (IL)36RN. In present study, we performed RNA sequence analysis on skin lesions from 10 GPP patients (4 with and 6 without IL36RN mutation) and 10 PV patients without IL36RN mutation. Compared with PV, significantly overexpressed genes in GPP patients were enriched in IL‐17 signalling pathway (MMP1, MMP3, DEFB4A and DEFB4B, etc.) and associated with neutrophil infiltration (MMP1, MMP3, ANXA and SERPINB, etc.). GPP with IL36RN mutations evidenced WNT11 upregulation and IL36RN downregulation in comparison to those GPP without IL36RN mutations. The expression of IL‐17A/IL‐36 in skin or serum and the origin of IL‐17A in skin were also investigated. IL‐17A expression in skin was significantly higher in GPP than PV patients, whereas, there were no differences in skin IL‐36α/IL‐36γ/IL‐36RA or serum IL‐17A/IL‐36α/IL‐36γ between GPP than PV. Besides, double immunofluorescence staining of MPO/IL‐17A or CD3/IL‐17A further confirmed that the majority of IL‐17A in GPP skin was derived from neutrophils, but not T cells. These data emphasized the role of neutrophil‐derived IL‐17A in the pathogenesis of GPP with or without IL36RN mutations. Targeting neutrophil‐derived IL‐17A might be a promising treatment for GPP.
Dyadic relationship of adult attachment patterns and interpersonal schemas in marital adjustment: Actor–partner effect model
Authors: Uluyol Fatma Mahperi , Özen‐Çıplak Ayça 
Published: February 2024

AbstractObjectiveThis study examined the associations between romantic attachment and relationship satisfaction as mediated by interp ersonal schemas (friendly × hostile) with Turkish couples.BackgroundPrevious studies showed that adult romantic attachment is strongly associated with couple relationship functioning, and many efforts have been made to identify the mechanisms underlying this link. However, no study has considered interpersonal schemas when investigating the connection between romantic attachment and marital adjustment in couples.MethodIn total, 230 Turkish married couples completed measures of interpersonal schemas, adult attachment, and marital adjustment.ResultsAttachment anxiety is indirectly related to marital adjustment in couples via interpersonal schemas. However, attachment avoidance is both directly and indirectly related to marital adjustment via interpersonal schemas. Whereas friendly schemas are related to attachment anxiety negatively, hostile schemas are related to both attachment anxiety and avoidance positively.ConclusionThe current study extended previous research by providing evidence concerning the influence of each partner's attachment dimension on the interpersonal schemas and marital adjustment of both spouses.ImplicationsIn romantic relationships being aware of the impact of interpersonal cycles on dyadic adjustment in clinical settings can help therapists shape their strategies in therapy sessions.
Paleogenomic insights into cooperation in the ancient Andes from positive selection on oxytocin pathway genes
Authors: Joseph Sophie K. , Wagman Elizabeth , Diab Nabeel , Ryu Nicholas , Lee Minwoo , Haas Randall , Rilling James K. , Aldenderfer Mark S. , Lindo John 
Published: February 2024

AbstractHuman societies are characterized by norms that restrict selfish behavior and promote cooperation. The oxytocin system is an important modulator of social behavior that may be involved in the evolution of cooperation. Oxytocin acts in both the nucleus accumbens and the anterior cingulate cortex to promote social bonding and social cohesion. Expression of the CD38 and OXTR genes is known to affect oxytocin secretion and binding, respectively, in these brain areas. The Andean highlands provide an excellent opportunity to evaluate the role of oxytocin in the evolution of cooperation. The rich archeological record spans 13,000 years of population growth and cooperative challenges through periods of highland exploration, hunting economies, agro‐pastoralism, and urbanization. Through allele trajectory modeling using both ancient and contemporary whole genomes, we find evidence for strong positive selection on the OXTR and CD38 alleles linked with increased oxytocin signaling. These selection events commenced around 2.5 and 1.25 thousand years ago, placing them in the region's Upper Formative and Tiwanaku periods—a time of population growth, urbanization, and relatively low rates of violence. Along with remarkable and enduring cultural developments, increased oxytocin secretion and receptor binding in these brain areas may have facilitated large‐scale cooperation that promoted early urbanization in the Titicaca Basin of the Andean highlands.
Prognostic value of the geriatric nutritional risk index and other hematological markers on long‐term survival in the geriatric population
Authors: da Costa Pereira Jarson Pedro , da Silva Diniz Alcides , de Lemos Maria Conceição Chaves , Ramiro Cláudia Porto Sabino Pinho , Cabral Poliana Coelho 
Published: February 2024

ObjectivesThe prognostic value of hematological markers has not been extensively explored in the geriatric population, particularly in the presence of the frailty phenotype among hospitalized individuals. Therefore, our study aimed to assess the influence of the frailty phenotype in hospitalized geriatric individuals on hematological markers and their impact on short‐ and long‐term outcomes.MethodsThis is a secondary analysis of a prospective cohort study. This study involved hospitalized individuals who were followed during their hospitalization and for nearly 2 years after discharge. At baseline, Fried's frailty phenotype was assessed, as well as hematological markers, including neutrophil–lymphocyte ratio, monocyte–lymphocyte ratio, neutrophil–monocyte ratio, platelet–lymphocyte ratio, systemic inflammation index, prognostic nutritional index, geriatric nutritional risk index (GNRI), and C‐reactive protein–albumin ratio. The phase angle derived from bioelectrical impedance analysis was likewise considered a prognostic biomarker. Our main outcomes were hospital length of stay and mortality during follow‐up.ResultsFrailty occurred in 43.2% of the population. Individuals with the frailty phenotype exhibited worse hematological markers and lower phase angle values. Low GNRI and elevated C‐reactive protein–albumin ratio values were independently associated with mortality (hazard ratio = 6.88, 95% confidence interval 2.0–23.6; hazard ratio = 2.2, 95% confidence interval 1.1–4.4). Only higher values of the systemic inflammation index were independently associated with prolonged hospital stays.ConclusionHematological markers may serve as a feasible tool for prognostic assessment. Individuals with the frailty phenotype and low GNRI represented a worst‐case scenario. Geriatr Gerontol Int 2024; 24: 312–318.
Queer processes of Hong Kong as a global formation post‐2019: LGBTIQ+ Hong Kong migrants and their experiences in Taiwan
Authors: Yu Ting‐Fai 
Published: February 2024

AbstractAlthough Hong Kong has always been transnational and its overseas communities longstanding, the queer experiences of diasporic Hongkongers have rarely been explored. Through interview‐based research, this article examines the experiences of LGBTIQ+ Hongkongers who migrated to Taiwan after the 2019–2020 Hong Kong protests, with the intention to accomplish three broader theoretical objectives. First, it introduces an intersectional approach to understanding the current Hong Kong diaspora by exploring how queerness came to shape and politicize a changing Hong Kong identity. Second, it considers Taiwan's role in global queer migration by investigating how it became a place of exception for LGBTIQ+ Hongkongers and, by extension, other ethnically Chinese queers. Lastly, it highlights how Hong Kong and Taiwan are linked by a structure of queer Sinophone consciousness, demonstrating how queerness and Chineseness are mutually productive and most amplified in transnational settings.
Preschool English language planning in China: Tensions between policy and practice
Authors: Li Xuan , Li Jialing 
Published: February 2024

AbstractThe earlier starting age for learning English is apparent in the non‐Anglophone world. However, in China, kindergartens are banned from delivering subjects that are designated for primary school level, including English language lessons, as part of reforms to eliminate “schoolification” of preschool education. This qualitative study takes a multi‐level approach to language‐in‐education planning to explore how local education authorities and different types of kindergartens in the city of Hefei, China, interpret and respond to this macro‐level policy. The findings reveal a disparity between officials and school participants in their attitudes toward preschool English language education, as well as divergence between public and private kindergartens in their current English provision. The study probes these disparities and their links to the interplay between the meso‐level local education authority and the different types of kindergartens, as well as the relationship between the government and the market.
Accuracy of automated analyzers for the estimation of CSF cell counts: A systematic review and meta‐analysis
Authors: Waldrop Greer E. , Cocuzzo Kaitlyn , Schneider Colleen L. , Kim Carla Y. , Goetz Teddy G. , Chomba Mashina S. , Delaurentis Clare E. , Smithgall Marie C. , Francis Richard O. , Thakur Kiran T. 
Published: February 2024

AbstractThis systematic review evaluates the evidence for accuracy of automated analyzers that estimate cerebrospinal fluid (CSF) white blood cell counts (WBC) compared to manual microscopy. Inclusion criteria of original research articles included human subjects, English language, and manual microscopy comparator. PUBMED, EMBASE and Cochrane Review databases were searched through 2019 and QUADAS‐2 Tool was used for assessment of bias. Data were pooled and analyzed by comparison method, using random effects estimation. Among 652 titles, 554 abstracts screened, 104 full‐text review, 111 comparisons from 41 studies were included. Pooled estimates of sensitivity and specificity (n = 7) were 95% (95%‐CI 93%–97%) and 84% (95%‐CI: 64%–96%), respectively. Pooled R2 estimates (n = 29) were 0.95 (95%‐CI: 0.95–0.96); Pooled spearman rho correlation (n = 27) estimates were 0.95 (95% CI 0.95–0.96). Among those comparisons using Bland–Altman analysis (n = 11) pooled mean difference was estimated at 0.98 (95% CI‐0.54–2.5). Among comparisons using Passing‐Bablok regressions (n = 14) the pooled slope was estimated to be 1.05 (95% CI 1.03–1.07). Q tests of homogeneity were all significant with the exception of the Bland–Altman comparisons (I2 10%, p value 0.35). There is good overall accuracy for CSF WBC by automated hematologic analyzers. These findings are limited by the small sample sizes and inconsistent validation methodology in the reviewed studies.
Teaching pulpectomy in paediatric dentistry: A national cross‐sectional survey of dental schools in Brazil
Authors: Campos Priscilla Sena Souza Luz , Gois Carla Marinho Barreto , Serafim Verônica , Puppin‐Rontani Regina Maria , Pascon Fernanda Miori 
Published: February 2024

AbstractBackgroundPulpectomy is used to treat primary teeth with irreversibly inflamed or necrotic pulp tissue. There is, however, a lack of consensus on clinical protocols for teaching pulpectomy at dental schools.AimTo determine what faculty members at Brazilian dental schools are teaching about pulpectomy in primary teeth.DesignA cross‐sectional, observational study was conducted using a 39‐question survey available via the Google Forms® platform. A snowball sampling strategy was used for recruitment. Invitations to participate were sent via e‐mail, WhatsApp® and Instagram®. The data were analysed descriptively.ResultsA total of 177 (58.4%) responses were obtained. Most faculty members recommended the use of Kerr hand files (66.1%), and 1% sodium hypochlorite was the most common choice for the irrigating solution (35.3%). Iodoform pastes were the first choice of faculty members (41.6%), and 60.5% of the faculty members recommended composite resin as the definitive restoration.ConclusionSimilarities were found in the teaching of pulpectomy for primary teeth among faculty members at dental schools in Brazil.
Comparative analysis of hip arthroscopy and open surgical dislocation for treating femoroacetabular impingement
Authors: Xiong Xinhai , Chen Wenjie , Chen Cheng , Li Chuan , Tan Haitao , Wu Anping 
Published: February 2024

AbstractThe purpose of this study was to compare the impact of hip arthroscopy group and open surgical dislocation group as treatments for femoroacetabular impingement (FAI) in young athletes, specifically in relation to early hip osteoarthritis. A systematic search was conducted across four databases to identify controlled trials comparing hip arthroscopy and open surgical dislocation for FAI treatment. The selected studies (9 in total) underwent rigorous literature assessment and data analysis using Review Manager (RevMan) 5.3 software. The meta‐ analysis revealed that there was no statistically significant difference between hip arthroscopy group (the test group) and the open surgical dislocation group (the control group) concerning the improvement of the alpha angle (Standardized Mean Difference [SMD]: ‐5.54; 95% Confidence Interval [CI]: ‐ 12.45,1.38; p = 0.117), the Modified Harris Hip Score (mHHS) after a 12‐ month follow‐ up (SMD:0.94; 95% CI:‐ 2.87,4.75; p = 0.629) and the complication rate (OR: 0.66; 95% CI: 0.26,1.65; p = 0.372). However, the meta‐ analysis revealed that the Nonarthritic Hip Score (NAHS) after a 12‐ month follow‐ up of the test group was significantly higher than that of the control group (SMD: 6.31; 95% CI: 0.53, 12.09; p = 0.032). In terms of the reoperation rate, it demonstrated a significantly lower rate in the test group compared to the control group (OR: 0.48; 95% CI: 0.29, 0.82; p < 0.01). These findings suggest that hip arthroscopy may have better outcomes for patients with FAI, as it is associated with improvements in hip function and a lower reoperation rate. However, these conclusions should be validated by further high‐ quality studies.
RETRACTED: Effect of intra‐wound vancomycin on the surgical site wound infection after spinal surgery: A meta‐analysis
Authors: Yang Chengcheng , Wang Qing , Zhao Wanqi 
Published: February 2024

AbstractThe topical application of the vancomycin in spine surgery is an effective method of reducing the incidence of postsurgical infections. However, there are differences in the prophylactic strategies used for various spinal surgeries. Therefore, the primary aim of this meta‐analysis was to evaluate the effectiveness of the application of the intra‐wound vancomycin during spine surgery. For this purpose, 100 studies were identified through different databases and search engines with various search terms such as ‘intrawound vancomycin in surgery’, ‘intrawound applications of vancomycin’, ‘vancomycin in surgery’, ‘intraoperative vancomycin’, ‘vancomycin spinal surgeries’, ‘treating surgical site infections in spinal surgeries using vancomycin’, ‘spinal surgery’, ‘vancomycin in spinal surgery’, ‘spine surgery’, ‘topical vancomycin’ and ‘local vancomycin’. Furthermore, the identified studies were reviewed thoroughly and finally, 19 studies were selected for meta‐analysis. The selected studies were included based on the inclusion criteria and data was extracted from the selected studies. The pool of the statistically significant studies was further analysed using the ‘meta’ package of R version 4.3.2. The analysed data resulted in statistically significant results with a p‐value <0.001 and the heterogeneity at 50% suggesting that the meta‐analysis results may be significant in supporting the application of vancomycin at surgical sites to reduce the surgical site infections and eventually improve the postoperative conditions by reducing the long hospital stays.
Interactive effects on ACC deaminase activity in salt‐tolerant plant growth‐promoting rhizobacteria and impacts on rice crop improvement
Authors: Reshma T. S. , Dileep C. 
Published: February 2024

AbstractThe present study focuses on the 1‐aminocyclopropane‐1‐carboxylic acid (ACC) deaminase assay and the rhizospheric interactions affecting enzyme activity. We investigate the efficacy of ACC deaminase‐producing rhizobacterial activity in alleviating salt stress in rice. Among the five selected isolates, only two strains, KFSC2 and PK7, possessed the enzyme activity. The amplification of the acdS gene resulted in gene identification in all five isolates. The newly designed primer in this study was suitable for both Pseudomonas and Enterobacter species. The gene products of KFSC1 and KFSC2 were amplified, sequenced and subsequently submitted to GenBank with accession numbers OQ703930 and OQ798805, respectively. This marks the first‐ever submission of the acdS gene sequence from Pseudomonas aeruginosa to GenBank. The interactive effect of root exudates on ACC deaminase activity was assessed using amino acids, organic acids and sugars. The highest enzyme activity was obtained with aspartic acid and fructose, while organic acids and varying pH levels had negative influences on enzyme activity. Additionally, salt and proline had positive effects. These results indicate that there is a positive interaction occurring among these compounds from plants and root‐colonizing bacteria. The selected strain PK7 had a significant impact on growth parameters. Moreover, yield resulted in 252 kg/hec over the control suggests its future possibility of promising bioformulations.
Investigate the relationship between densification and grain size of IGZO target by phase‐field simulation
Authors: Liu Xiaokai , Sun Benshuang , Zhang Wenyu , Zhang Huiyu , Zhao Hetao , Zhao Yongge , Shu Yongchun , Liu Yang , He Jilin 
Published: February 2024

AbstractThe phase‐field method was employed to simulate the effects of pores on grain growth in the indium gallium zinc oxide (IGZO) targets during conventional and two‐stage sintering (TSS). The findings indicated that the TSS method effectively suppressed the rapid growth of grains. With an increase in porosity and a more prominent pore size, the rate of grain growth accelerated, resulting in the formation of coarser grains. Subsequently, IGZO targets were fabricated using the molding‐cold isostatic pressing (CIP) and TSS methods. The densification activation energies of IGZO green compacts were calculated to be 510 and 370 kJ/mol for CIP at 180 and 250 MPa, respectively, utilizing the main sintering curve (MSC). Additionally, by optimizing the TSS process, a highly dense IGZO target with a relative density of 99.53%, a resistivity of 4.3 mΩ/cm, and an average grain size of 8.59 µm was successfully achieved.
The role of leadership in nurses' wellbeing and performance: A cross‐sectional survey using a dual motivational pathway model
Authors: Holtan Kristin Hjelmtvedt , Halvari Anne Elisabeth Münster , Olafsen Anja Hagen , Øvergård Kjell Ivar , Halvari Hallgeir 
Published: February 2024

AbstractAimTo examine the positive motivational paths from perceived autonomy‐supportive leadership, and the negative motivational paths from perceived controlling leadership to satisfaction and frustration of basic psychological needs, work motivation, work performance, work engagement and somatic symptom burden among nurses using Self‐Determination Theory.DesignThe study used a cross‐sectional design mapping nurses' perceptions of the various study variables through a survey.MethodsNurses working in the municipal healthcare in Norway were recruited through an electronic questionnaire sent out via a link to their emails between 29th of August and 29th of September 2020. Of them, 219 nurses completed the questionnaire. Study hypotheses were tested using structural equation modelling.ResultsHigher levels of perceived autonomy‐supportive leadership were associated with reduced levels of somatic symptom burden and increased levels of work performance and work engagement through the satisfaction of basic psychological needs and autonomous motivation, specifically identified regulation and intrinsic motivation. Perceptions of controlling leadership were associated with heightened levels of somatic symptom burden through basic psychological need frustration, amotivation and introjected motivation, along with lower levels of work engagement through need frustration and amotivation.ConclusionThis study underscores the positive motivational paths of perceived autonomy‐supportive leadership on nurses' work performance and wellbeing through the facilitation of basic psychological need satisfaction and autonomous motivation. Conversely, the study highlights negative motivational paths of perceived controlling leadership on reduced work engagement and heightened ill‐being through the basic psychological need frustration, controlled motivation and amotivation.ImpactThis study provides insights and actionable recommendations for nurses and their leaders, emphasizing the significance of understanding the adverse impact associated with perceived controlling leadership. The findings underscore the importance of addressing these issues to mitigate detrimental effects on motivation and overall work functioning.Patient or Public ContributionNo patient or public contribution.