bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of extracellular vesicles as a cell-free therapy in colitis: a systematic review and meta-analysis of animal studies
Authors: Hou Jun-Jie , Li Wei-Wei , Wang Xiao-Li , Ma A-Huo , Qin Yue-Hua 
Published: October 2023

Background: Extracellular vesicles (EVs) mediate inflammation, immune responses, gut barrier integrity, and intestinal homeostasis. Recently, the application of EVs in the treatment of inflammatory bowel disease (IBD) has been under intensive focus. Some studies have been conducted in animal models of colitis, while systematic reviews and meta-analyses are lacking. The current study aimed to conduct a systematic review and meta-analysis of studies investigating the efficacy of EVs on IBD.Methods: A systematic retrieval of all studies in PubMed, EMBASE, MEDLINE, Web of Science, and Cochrane Library reported the effects of EVs in the colitis model up to 22 June 2023. The methodological quality was assessed based on SYRCLE’s risk of bias (RoB) tool. Disease activity index (DAI), myeloperoxidase activity (MPO), histopathological score (HS), and inflammatory cytokines (TNF-α, NF-κB, IL-1β, IL-6, and IL-10) were extracted as analysis indicators by Web Plot Digitizer 4.5. A meta-analysis was performed to calculate the standardized mean difference and 95% confidence interval using random-effect models by Review Manager 5.3 and STATA 14.0 software.Results: A total of 21 studies were included in this meta-analysis. Although the heterogeneity between studies and the potential publication bias limits confidence in the extent of the benefit, EV treatment was superior to the control in the colitis evaluation with reduced DAI, HS, MPO activity, and pro-inflammatory cytokines, including TNF-α, NF-κB, IL-1β, and IL-6, while increasing the content of anti-inflammatory cytokine IL-10 (all p &lt; 0.05).Conclusion: Our meta-analysis results supported the protective effect of EVs on colitis rodent models based on their potential role in IBD therapy and propelling the field toward clinical studies.
Twenty-four years lucerne (Medicago sativa L.) breeder seed production in India: a retrospective study
Authors: Chand Subhash , Roy Ajoy Kumar , Singh Tejveer , Agrawal Rajiv Kumar , Yadav Vijay Kumar , Kumar Sanjay , Malaviya Devendra Ram , Chandra Amaresh , Yadava Devendra Kumar 
Published: October 2023

Lucerne (Medicago sativa L.) is the second most significant winter leguminous fodder crop after berseem in India. Breeder seed (BS) is the first stage of the seed production chain, as it is the base material for producing foundation and certified seeds. In India, lucerne BS demand has been reduced by 85.58% during the last 24 years (1998–1999 to 2021–2022), declining from 2150 kg to 310 kg. Out of 14 varieties released and notified so far, only nine varieties entered the seed chain since 1998–1999. It shows narrow varietal diversification and, hence, needs robust breeding programs towards enriching genetic variability and varietal development. The present study also highlights the disparity in BS demand and production over the years and puts forth the possible reasons behind the reduction in BS demand and production in the country. Out of the nine varieties, the BS demand of Anand-2 (53.11%) was highest, followed by Type-9 (19.44%) and RL-88 (13.60%). Varietal replacement rate (VRR) was found to be moderate, i.e., 23.67% for the varieties having &lt;5 years old age in the last 3 years (2019–2020 to 2021–2022). It has also been estimated that BS produced (233 kg) during 2021–2022 can cover the approximate area of 6,300 ha at farmers’ fields in 2024–2025 if the seed chain functions 100%, effectively. The present study provides a holistic overview of lucerne BS demand and production, challenges in BS production, and the way forward to develop more varieties and surplus BS production in the country.
Children’s pre-academic school readiness and home learning activities: a moderated-mediation analysis of home visiting
Authors: Avelar Daniela , Hull Darrell , Middlemiss Wendy 
Published: October 2023

IntroductionThe current study explores the relation between parent involvement and children’s school readiness for 568 families enrolled in the Home Instruction of Preschool Youngsters (HIPPY) program in Texas. Parent involvement in children’s learning is a focus of the HIPPY curriculum.MethodsIn this analysis, conditional process models were run to examine the relations between children’s school readiness and engagement in home learning activities, parents’ education level, program language (English or Spanish), both before and after completing a year of the program.ResultsAt pretest but not posttest, program language moderated the direct relation between parents’ education level and children’s school readiness and parents with high levels of education were more likely to engage their children in educational activities. Engagement in home learning activities was associated with school readiness regardless of parents’ education level and language.DiscussionThese findings provide a better understanding of the variables associated with school readiness for HIPPY families, indicating the importance of home learning activities—a variable that may be more amenable to change within intervention programs. Thus, focusing on home learning activities may contribute to decreasing discrepancies in children’s preparedness for school entry that are generally identified across language and parent education. Findings may have practical implications for other home visitor programs working with similar populations.
Top management team career experience heterogeneity, digital transformation, and the corporate green innovation: a moderated mediation analysis
Authors: Gao Daquan , Li Songsong , Guo Chang 
Published: October 2023

IntroductionDrawing upon upper echelon theory and the resource-based view, this study employs a moderated mediation model to investigate the moderating role and underlying mechanisms of digital transformation in the influence of top management teams (TMT) on corporate green innovation.MethodsOur analysis of panel data from 19,155 Chinese A-share listed companies (2011–2020) demonstrates that TMT career experience heterogeneity has a positive effect on green innovation, a relationship that is further strengthened by digital transformation.ResultsThis study shows the role of digital transformation in amplifying the effects of TMT diversity on green innovation and the crucial role of industry-academia-research collaboration as a mediator. Heterogeneity analysis highlights that non-state-owned enterprises (non-SOEs) show more agility than state-owned enterprises (SOEs) in leveraging heterogeneous TMT to drive green innovation. Conversely, green innovation in SOEs benefits more from digital transformation, which includes both its direct and indirect effects of digital transformation. Enterprises located in non-Yangtze River Economic Belt regions benefit more from digital transformation, demonstrating the importance of a balanced distribution of digital resources.DiscussionThis study provides novel insights into leveraging inclusive leadership and digital capabilities to enhance ecological sustainability. This study underscores the potential of diversified TMTs and digitalization technology integration to catalyze green innovation, which is critical for environmentally responsible transformation.
Trends in prescription therapy for adolescents with depression in nine major areas of China during 2017–2021
Authors: Wang Li , Zhou Linpo , Zhu Yao , Yan Jingjing , Bu Na , Fei Weidong , Wu Fan 
Published: October 2023

ObjectiveTo date, no national-scale drug usage survey for adolescents with depression has been conducted in China, and the purpose of this study was to examine the national trends in prescriptions in Chinese adolescent depression patients from 2017 to 2021.MethodsPrescribing data were extracted from the Hospital Prescription Analysis Cooperative Project. The average number of patients per year, the cost of treatment, and the prescription patterns (monotherapy vs. combination therapy) were analyzed, and subgroup analyses were conducted depending on age, sex, and drug class.ResultsThe study included 674,099 patients from 136 hospitals located in nine major areas of China. Of all patients, the proportion of adolescents increased from 1.63% in 2017 to 6.75% in 2021. Visits by adolescent depression patients increased from 1,973 in 2017 to 9,751 in 2021, and the corresponding cost increased from 607,598 Chinese Yuan in 2017 to 2,228,884 Chinese Yuan in 2021. The incidence of adolescent depression among female individuals was far beyond that among male individuals. Combination therapy was more frequent than monotherapy, and the most commonly prescribed drugs were antidepressants, antipsychotics, antiepileptics, and antianxietics. Despite the use of sertraline decreasing from 47.90 to 43.39%, it was the most frequently used drug.ConclusionIn summary, the prescriptions and cost of treatment for adolescent depression patients both increased rapidly. The widespread use of those drugs with weak clinical evidence reflects the current state of China, which should arouse our attention. The study can provide references for clinical treatment decisions and a basis for more efficient allocation of healthcare resources by the government.
Understanding cross-data dynamics of individual and social/environmental factors through a public health lens: explainable machine learning approaches
Authors: Jeong Siwoo , Yun Sung Bum , Park Soon Yong , Mun Sungchul 
Published: October 2023

IntroductionThe rising prevalence of obesity has become a public health concern, requiring efficient and comprehensive prevention strategies.MethodsThis study innovatively investigated the combined influence of individual and social/environmental factors on obesity within the urban landscape of Seoul, by employing advanced machine learning approaches. We collected ‘Community Health Surveys’ and credit card usage data to represent individual factors. In parallel, we utilized ‘Seoul Open Data’ to encapsulate social/environmental factors contributing to obesity. A Random Forest model was used to predict obesity based on individual factors. The model was further subjected to Shapley Additive Explanations (SHAP) algorithms to determine each factor’s relative importance in obesity prediction. For social/environmental factors, we used the Geographically Weighted Least Absolute Shrinkage and Selection Operator (GWLASSO) to calculate the regression coefficients.ResultsThe Random Forest model predicted obesity with an accuracy of &gt;90%. The SHAP revealed diverse influential individual obesity-related factors in each Gu district, although ‘self-awareness of obesity’, ‘weight control experience’, and ‘high blood pressure experience’ were among the top five influential factors across all Gu districts. The GWLASSO indicated variations in regression coefficients between social/environmental factors across different districts.ConclusionOur findings provide valuable insights for designing targeted obesity prevention programs that integrate different individual and social/environmental factors within the context of urban design, even within the same city. This study enhances the efficient development and application of explainable machine learning in devising urban health strategies. We recommend that each autonomous district consider these differential influential factors in designing their budget plans to tackle obesity effectively.
The First Genome Survey of the Snail Provanna glabra Inhabiting Deep-Sea Hydrothermal Vents
Authors: Hui Min , Zhang Yu , Wang Aiyang , Sha Zhongli 
Published: October 2023

The snail P. glabra is an endemic species in deep-sea chemosynthetic ecosystems of the Northwest Pacific Ocean. To obtain more genetic information on this species and provide the basis for subsequent whole-genome map construction, a genome survey was performed on this snail from the hydrothermal vent of Okinawa Trough. The genomic size of P. glabra was estimated to be 1.44 Gb, with a heterozygosity of 1.91% and a repeated sequence content of 69.80%. Based on the sequencing data, a draft genome of 1.32 Gb was assembled. Transposal elements (TEs) accounted for 40.17% of the entire genome, with DNA transposons taking the highest proportion. It was found that most TEs were inserted in the genome recently. In the simple sequence repeats, the dinucleotide motif was the most enriched microsatellite type, accounting for 53% of microsatellites. A complete mitochondrial genome of P. glabra with a total length of 16,268 bp was assembled from the sequencing data. After comparison with the published mitochondrial genome of Provanna sp. from a methane seep, 331 potential single nucleotide polymorphism (SNP) sites were identified in protein-coding genes (PCGs). Except for the cox1 gene, nad2, nad4, nad5, and cob genes are expected to be candidate markers for population genetic and phylogenetic studies of P. glabra and other deep-sea snails. Compared with shallow-water species, three mitochondrial genes of deep-sea gastropods exhibited a higher evolutionary rate, indicating strong selection operating on mitochondria of deep-sea species. This study provides insights into the genome characteristics of P. glabra and supplies genomic resources for further studies on the adaptive evolution of the snail in extreme deep-sea chemosynthetic environments.
Exosome Liberation by Human Neutrophils under L-Amino Acid Oxidase of Calloselasma rhodostoma Venom Action
Authors: Serrath Suzanne N. , Pontes Adriana S. , Paloschi Mauro V. , Silva Milena D. S. , Lopes Jéssica A. , Boeno Charles N. , Silva Carolina P. , Santana Hallison M. , Cardozo Daniel G. , Ugarte Andrey V. E. , Magalhães João G. S. , Cruz Larissa F. , Setubal Sulamita S. , Soares Andreimar M. , Cavecci-Mendonça Bruna , Santos Lucilene D. , Zuliani Juliana P. 
Published: October 2023

L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of Calloselasma rhodostoma snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exosome formation, and content. Neutrophils isolated from healthy donors were stimulated with Cr-LAAO (100 μg/mL) for 3 h, followed by exosome isolation and analysis. Results show that Cr-LAAO induces the release of exosomes with distinct protein content compared to the negative control. Proteomic analysis reveals proteins related to the regulation of immune responses and blood coagulation. This study uncovers Cr-LAAO’s ability to activate human neutrophils, leading to exosome release and facilitating intercellular communication, offering insights into potential therapeutic approaches for inflammatory and immunological disorders.
Evolution of Preservation Donor Blood and its Erythrocyte Components Under Positive Temperature Conditions (to the 90th Anniversary of the Method Application in the Blood Service in Belarus)
Authors: Гольдинберг Б.М. , Климович О.В. 
Published: October 2023

Цель. Обобщить предшествующий исторический опыт применения в Беларуси методов консервирования крови и ее компонентов. Материалы и методы. Материалом исследования стали как литературные источники о разработках и применении стабилизаторов крови в мировом масштабе, так и статистические данные в Беларуси. Проведен сравнительный анализ применения прописей консервирующих средств и методов с оценкой их клинической эффективности при оказании трансфузиологической помощи. Результаты. Проведен исторический обзор применения методов консервирования донорской крови, ее эритроцитных компонентов при положительном температурном режиме на протяжении 1932–2022 годов в Беларуси. Обсуждены достоинства заготовки посмертной крови, которая практиковалась с 1935 по 1972 г. в Беларуси (Жлобин, Минск, Гомель), и возможные перспективы возврата к нему при ортотопической трансплантации печени. Описан опыт применения отечественного препарата M-1-фосфат целлюлозы для заготовки сорбентной донорской крови. Выводы. Наряду с общими тенденциями применения рецептуры консервирующих растворов донорской крови, ее эритроцитных компонентов, применявшихся в СССР и в постсоветское время, в национальной службе крови имелись собственные разработки методов заготовки крови, в том числе посмертной и донорской.
Purpose. To summarize the previous historical experience of using methods of preserving blood and its components in Belarus. Materials and methods. The material of the study became literary sources on the development and use of blood stabilizers both on a global scale and statistical data in Belarus. A comparative analysis of the use of prescriptions of preservatives and methods with an assessment of their clinical effectiveness in the provision of transfusiological care have been carried out. Results. A historical review of the applying methods of preservation donor blood and its erythrocyte components under positive temperature conditions during 1932–2022 in Belarus has been carried out. The advantages of postmortem blood banking practiced from 1935 to 1972 in Belarus (Zhlobin, Minsk, Gomel) and possible prospects for returning to it during orthotopic liver transplantation have been discussed. The experience of using the domestic drug M-1-cellulose phosphate for sorbent donor blood banking has been described. Conclusions. Along with the general trends in the use of formulations of preservative solutions of donor blood and its erythrocyte components used in the fomer USSR and in the post-Soviet period, the national blood Service had its own development of methods of blood banking, including postmortem and donor ones.
ALMANYA’DAKİ TÜRK İŞÇİLERİN ANAVATANA BAĞIŞLARININ TÜRKİYE’NİN SOSYOEKONOMİK KALKINMASINDAKİ ROLÜ (1961-1980)
Authors: YILMAZ Duygu 
Published: October 2023

Göç, insanların yaşadığı coğrafyadan ayrılarak barış, güvenlik, çalışma gibi imkanlara kavuşacağı coğrafyaya taşındığı bir nüfus hareketliliğidir. II. Dünya Savaşı’nın ardından Avrupa’da oluşan işgücü açığı 1960’lı yılların başına kadar giderek artmış, bu gelişme Türkiye’yi yakından ilgilendirmiştir. Türkiye, Batı Avrupa ülkeleri başta olmak üzere yurtdışına işçi göndermiştir. Ekonomik kalkınma sürecini düşük ücretle çalışacak işçi göçüyle hızlandırmak isteyen Almanya’nın Türkiye’yle bağlantısı, 1961’de kurulmuştur. Karşılıklı beklentilerle şekillenen bu hareketlilikte Türkiye, işsizlik sorununa çare arayışı içerisindedir. Türk vatandaşların daha iyi yaşam koşulları için Almanya’ya göç etmesi, Türkiye ekonomisi için yeni bir kaynak yaratmıştır: Bağışlar. Almanya’da yaşayan Türk işçiler, Türkiye’nin çeşitli bölgelerine gönderdikleri bağışlarla yerelde sosyal ve ekonomik kalkınmaya katkı sağlamışlardır. Bu bağış, ya ücra bir köyde okul açılmasına hizmet etmiş ya bir sağlık merkezinin ihtiyacını gidermiş veyahut yoksullara yardım amacıyla kurulan derneklere kaynak olmuştur. Bunlarla birlikte Almanya’daki Türk işçilerin gönderdikleri bağışlarla bir köy camisinin ihtiyaçları karşılanmıştır. Bu etkileşim, göçmen işçinin anayurduyla bağını korumuştur. Bu çalışmada; 1961’de Almanya ile Türkiye arasında imzalanan işgücü antlaşması ile başlayan Almanya’ya işçi göçünün sosyoekonomik anlamda Türkiye üzerindeki etkileri konu edilmiştir.
Almanya’daki işçilerin bağışlar yoluyla Türkiye’nin kalkınmasında oynadığı rolün değerlendirildiği çalışmada, tarihsel yöntem kullanılmıştır. Tarihsel yöntem çerçevesinde veriler, doküman incelemesine tabi tutulmuştur. Araştırma verilerinin toplanması ve analizi olarak tanımlanan doküman incelemesinde, 1961’den 1980’lere uzanan süreçte, Almanya’daki Türk işçilerin Türkiye’ye gönderdiği bağışlar, örnekler dikkate alınarak değerlendirilmiştir. Çalışmanın içeriği, Devlet Arşivleri Başkanlığı Cumhuriyet Arşivi’nden elde edilen belgeler ve konu hakkında yazılmış birinci el kaynaklarla desteklenerek oluşturulmuştur. Ayrıca gazeteler de kaynak açısından çalışmayı desteklemiştir.
An Overview Of Cases Of Violence Against Women And Children In Tasikmalaya City
Authors: Sholihat Neni , Miftahul Falah  , Rossy Rosnawanti  , Heri Budiawan  
Published: October 2023

Since 1984, the Government of Indonesia has shown its concern for issues of women's empowerment and child protection. There are no fewer than a dozen policies issued by the government to manage and prevent incidents of violence against women and children. The city of Tasikmalaya is one of the cities that already has a mayoral regulation to manage this issue, by issuing mayoral regulation no. 102 of 2016 concerning woman empowerment and child protection. But, from year to year, the number of cases of violence against women and children is increasing, both quantitatively and qualitatively, with increasingly diverse types of violence. The purpose of this study was to see an overview of cases of violence against women and children in Tasikmalaya city. The Descriptive method with cross sectional approach was used in this study. The results showed that the most common type of violence was sexual harassment, with the most victims of violence being women, with the highest level of education of victim being elementary and junior high school, and the relationship between the perpetrator and the victim was mostly family, with the scene of the incident in the neighbourhood or a place known to the victim. In conclusion, female gender, elementary and junior high school education, and family are a real picture related to cases of violence against women and children in Tasikmalaya. It is recommended that socialization regarding the prevention of violence against women and children be carried out continuously. Improve the competence of officers who provide women and child protection services and periodic monitoring of service activities by including physical evidence of reporting as well.
Intervention and Responding to Internet Addiction of Minors Under the Perspective of Community Policing
Authors: Wu Jieli , Miao Ying 
Published: October 2023

With the increasing popularity of Internet use among minors in China, more and more minors appear to use the Internet excessively and even become addicted to it. Community policing, as an important force of community collaborative governance, plays an irreplaceable role in intervening and responding to juvenile Internet addiction behaviors. In the practice of community policing, it is found that the prevention and suppression of minors’ Internet addiction behavior also needs the information-sharing, coordination and cogovernance of multiple social actors.
This paper collects the work of the community police in preventing and curbing the excessive use of the Internet by minors, focusing on profile of Internet-addicted minors, definition, causes and harmful consequences of such deviant behavior. At the same time, based on the deviant behavior theory and the practical experience of community policing, this paper, from two aspects of prevention and suppression, aims to further improve the on-going collaborative intervention mechanism of «police-home-school-community» through sharing, coordination and co-governance directed against minors’ Internet addiction.