bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relaksasi Otot Progresif Terhadap Penurunan Kecemasan Pada Keluarga Pasien ICU
Authors: Wirawati Maulidta Karunianingtyas , Aini Dwi Nur 
Published: February 2025

memberikan perawatan pasien dengan kondisi kritis dan potensial mengancam jiwa. Bagi keluarga pasien, ICU merupakan tempat paling tidak menyenangkan karena respon emosional keluarga dituntut lebih tinggi dibanding ruangan lainnya dan ketepatan dalam pengambilan keputusan bagi kelangsungan hidup anggota keluarganya. Respon emosional yag sering terjadi pada keluarga pasien yang di rawat di ruang ICU seperti ketegangan, ketakutan, kecemasan dan kewaspadaan. Kecemasan yang tinggi muncul akibat beban yang harus diambil dalam pengambilan keputusan dan pengobatan yang terbaik bagi pasien. Berbagai terapi komplementer telah dikembangkan sebagai penatalaksanaan kecemasan, stress fisik dan psikologis seperti relaksasi otot progresif (ROP). Metode Penelitian Telaah eksperimen memakai metode kuantitatif dengan desain Purposive Sampling melalui pendekatan onegroup pre-test dan post-test design bertujuan mengetahui adanya pengaruh pemberian relaksasi otot progresif terhadap kecemasan keluarga pasien ICU di RS Permata Medika Semarang. Jumlah populasi yang diambil dalam penelitian ini adalah sebanyak 30 orang. Teknik pengambilan sampel menggunakan Accidental Sampling.
Hasil penelitian relaksasi otot progresif menunjukkan adanya pengaruh yang berarti. terhadap penurunan kecemasan keluarga pasien diruang ICU dengan nilai p value 0,046
Kesimpulan Hasil penelitian relaksasi otot progresif menunjukkan adanya pengaruh terhadap penurunan kecemasan keluarga pasien diruang ICU. Hasil penelitian ini diharapkan menjadi evidence based practice bagi perawat ruang ICU dalam memberikan intervensi kepada keluarga pasien yang mengalami kecemasan yang berpengaruh terhadap fungsi keluarga dalam merawat pasien ruang ICU.
What matters for environmental concerns among university students in Bangladesh? An empirical study
Authors: Saha Bijoya , Ahmed Mufti Nadimul Quamar , Ahmed Khandaker Jafor , Atiqul Haq Shah Md 
Published: February 2025

IntroductionExperts have a well-established consensus regarding the detrimental effects of human activities on the environment, including extreme temperature events, rainfall variability, pollution, deforestation, biodiversity loss, and flood occurrences—all of which significantly stress Earth’s natural systems. This study investigates the level of environmental concern among university students in Bangladesh, considering their socio-demographic factors.MethodsA comprehensive survey was conducted using a self-administered questionnaire targeting 380 final-year bachelor and master’s students from various academic disciplines at Shahjalal University of Science and Technology (SUST) Sylhet, Bangladesh. The analysis involved variables such as gender, completion of university courses related to the environment or climate change, disciplinary background, and vulnerability to climate change or extreme weather events in their home locality. Relationships between these variables and the students’ environmental concerns were examined using cross-tabulation with the Chi-square test and mean difference with the ANOVA test.ResultsThe findings indicate a high level of knowledge and significant concern among students regarding environmental issues, with disciplinary background being the primary determinant of environmental concern level. Additionally, completing university courses on environmental or climate change topics and experiencing vulnerability to such events in one’s hometown are significant predictors of environmental concerns.DiscussionThis study highlights the growing environmental concerns among university students and underscores the need for further scientific research to comprehensively understand their impact on population dynamics.
A comparison of applicant and accepted student characteristics to research training programs with implications for recruitment and selection strategy
Authors: Cho Young-Hee , Chun Chi-Ah , Ramos Hector , Buonora Paul , Narayanaswami Vasanthy , Vu Kim-Phuong L. 
Published: February 2025

IntroductionVery few studies have examined the relationship between student characteristics and their acceptance to research training programs that use holistic selection. The present study addressed this question using institutional and applicant data of three NIH undergraduate training programs at California State University, Long Beach. Its first aim was to examine whether the applicants to the training programs were representative of the broader campus population. Its second aim was to investigate whether applicants who were accepted to the programs using a holistic selection process differed in academic discipline, demographics, and psychosocial characteristics from applicants who were not accepted.MethodsInformation on students’ majors, race/ethnicity, and gender was obtained from the university records or applications submitted by students. Majors were categorized as either biomedical or behavioral disciplines, while URM status was defined as students who self-identified their race and ethnicity as African American/Black, Native American, Native Hawaiian/Pacific Islander, or Hispanic. Applicants’ psychosocial characteristics were obtained from a separate online survey. The acceptance status of applicants was obtained from the training programs’ records.ResultsThe applicant and non-applicant groups showed similar distribution of demographic characteristics regarding URM status and gender. Moreover, students’ academic discipline and other demographic variables were not associated with application status at either the lower division (LD) or upper division (UD) levels. Although psychosocial characteristics measured with the online survey were not considered in the selection process, post-hoc analyses showed that LD applicants with higher grit and UD applicants with higher science interests were more likely to be accepted to the programs.ConclusionThe equal representation of URM and female students in the applicant and non-applicant groups suggests that students from these traditionally underrepresented groups in STEM were just as likely to apply to our training programs. Furthermore, while the holistic selection process resulted in comparable acceptance rates across URM status and gender, it appeared to favor LD applicants with higher grit and UD students with higher science interests. These findings imply that research training programs can effectively recruit diverse students from underrepresented populations in STEM by using intentional outreach and recruitment efforts coupled with an objective and holistic selection process.
Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study
Authors: Maddalo Michele , Petraroli Maddalena , Ormitti Francesca , Fulgoni Alice , Gnocchi Margherita , Masetti Marco , Borgia Eugenia , Piccolo Benedetta , Turco Emanuela C. , Patianna Viviana D. , Sverzellati Nicola , Esposito Susanna , Ghetti Caterina , Street Maria E. 
Published: February 2025

BackgroundThe aim of the study was to explore a radiomic model that could assist physicians in the diagnosis of central precocious puberty (CPP). A predictive model based on radiomic features (RFs), extracted form magnetic resonance imaging (MRI) of the pituitary gland, was thus developed to distinguish between CPP and control subjects.Methods45 girls with confirmed diagnosis of CPP (CA:8.4 ± 0.9 yr) according to the current criteria and 47 age-matched pre-pubertal control subjects (CA:8.7 ± 1.2 yr) were retrospectively enrolled. Two readers (R1, R2) blindly segmented the pituitary gland on MRI studies for RFs and performed a manual estimation of the pituitary volume. Radiomics was compared against pituitary volume in terms of predictive performances (metrics: ROC-AUC, accuracy, sensitivity and specificity) and reliability (metric: intraclass correlation coefficient, ICC). Pearson correlation between RFs and auxological, biochemical, and ultrasound data was also computed.ResultsTwo different radiomic parameters, Shape Surface Volume Ratio and Glrlm Gray Level Non-Uniformity, predicted CPP with a high diagnostic accuracy (ROC-AUC 0.81 ± 0.08) through the application of our ML algorithm. Anthropometric variables were not confounding factors of these RFs suggesting that premature thelarche and/or pubarche would not be potentially misclassified. The selected RFs correlated with baseline and peak LH (p &lt; 0.05) after GnRH stimulation. The diagnostic sensitivity was improved compared to pituitary volume only (0.76 versus 0.68, p&lt;0.001) and demonstrated higher inter-reader reliability (ICC&gt;0.57 versus ICC=0.46).DiscussionRadiomics is a promising tool to diagnose CPP as it reflects also functional aspects. Further studies are warranted to validate these preliminary data.
Coordinated frequency modulation strategy considering source–load uncertainty
Authors: Dong Xiaohong , Wang Shuo , Ai Dengxin , Ma Yang , Yu Xiaodan 
Published: February 2025

IntroductionWind turbine generators (WTGs) and electric vehicles (EVs) are used as source-side and load-side resources, respectively. And the uncertainties of WTGs output and EVs charging load seriously affect the frequency stability of the power system. For the wind speed prediction error and the uncertainty of EV off-grid time, a cooperative frequency modulation (FM) strategy is proposed.MethodsFirstly, the wind speed interval is divided based on the operating characteristics of WTGs and the load reduction rate. On the basis, a load reduction operation strategy based on rotor speed control and pitch Angle control is proposed to enable WTGs to have bidirectional FM capability. The adjustable capacity of WTGs is determined based on the wind speed prediction error and the operation strategy of load reduction; Secondly, based on the controllable domain model of an EV considering the off-grid time uncertainty, the adjustable capacity of EV clusters is determined by state grouping of the state of charge (SOC) according to its charging urgency. By defining EV FM capability parameters and charging urgency parameters, the EV priority list for FM is determined and the power allocation strategy is proposed; Then, based on the urgency of EV charging and the economy of WTGs load reduction operation, a cooperative FM task assignment strategy is proposed.ResultsSimulations demonstrate the strategy enhances FM capability and improves FM effect by 6.05% compared to fixed-proportion task allocation. It strengthens frequency stability by leveraging complementary strengths.DiscussionConsideration of wind speed prediction errors can improve WTG adjustable capacity estimation, boosting FM accuracy; Coordinated task allocation minimizes WTGs intermittent FM output impacts, ensuring stable grid frequency. This dual-source-load approach offers a robust solution for modern power systems with high renewable penetration.
Association of combined pulmonary fibrosis and emphysema in rheumatoid arthritis with high titer of rheumatoid factor and autoimmunity to the lung
Authors: Ma Aiping , Huang Renliang , Guo Jiaxi , Wang Guangdong , Huang Heqing , Li Xinze , Zhong Shan , Huang Yan , Lin Shaowei , Lin Yikai , Zhou Qiaomiao , Krauss-Etschmann Susanne , Petersen Frank , Wang Zhanxiang , Yu Xinhua 
Published: February 2025

BackgroundCombined pulmonary fibrosis and emphysema (CPFE) commonly coexists with connective tissue diseases (CTD), such as rheumatoid arthritis (RA). However, the risk factors contributing to the development of CTD-CPFE remain largely unidentified. This study aimed to characterize CPFE using a large cohort of consecutive RA patients and to elucidate potential risk factors associated with RA- CPFE development.MethodsA total of 976 RA patients were enrolled in this cross-sectional study to characterize RA-CPFE. Multiple logistic analyses were conducted to identify potential risk factors for RA-CPFE development. Patient IgG and IgM autoantibodies to primary human bronchial epithelial cells (HBEC) from healthy donors were assessed using flow cytometry.FindingsAmong the 976 RA patients, 414 (42.4%) developed interstitial lung disease (ILD), with 74 (7.6%) experiencing CPFE. In comparison to RA-CPFE patients with centrilobular or paraseptal emphysema, those with panacinar emphysema had higher emphysema scores and decreased pulmonary function parameters. Multiple logistic regression analysis revealed that male gender, cigarette smoking, occupational exposure to dust, high ILD score, high rheumatoid factor (RF) titers, and the presence of anti-SSA were associated with an increased risk for RA-CPFE. Additionally, levels of IgG and IgM autoantibodies to HBEC were elevated in RA-CPFE patients compared to healthy controls and positively correlated with RF levels.InterpretationThis study is the first to demonstrate the association of RA-CPFE with high titer of RF and the presence of autoantibodies against HBEC, suggesting a link between autoimmunity to the lung and RA-CPFE.
Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration
Authors: Stürzbecher Lucas , Bartolomaeus Hendrik , Bartolomaeus Theda U. P. , Bolz Sylvia , Sekulic Andjela , Ueffing Marius , Clark Simon J. , Reichhart Nadine , Crespo-Garcia Sergio , Wilck Nicola , Strauß Olaf 
Published: February 2025

IntroductionAge-related macular degeneration (AMD) is a leading cause of blindness with limited treatment options. Dysfunction of the retinal pigment epithelium (RPE) is a unifying salient feature of the pathology and a primary end-point damage leading to complications such as geographic atrophy (GA), which represents the most common end-stage of AMD.MethodsHuman and murine ocular tissues were used for histological examinations. Furthermore, flow cytometry and gene expression analysis were used on ocular and splenic tissues of Cx3cr1GFP/GFP and C57BL/6J mice at 8 and 12 months of age to characterize the dynamics of local and systemic T cell populations.ResultsWe show the presence of memory T cells such as CD45RO+ cells in the choroid and retina of patients with AMD with a peak of abundance in early stages of AMD. As further evidence for the contribution of the adaptive immune system to GA we identified an increased frequency of CD44+ CD69+ KLRG1+ T cells and para-inflammation of the retina in a mouse model that mimics features of GA. Importantly, the activation of T cells found at early AMD-like stages prior to degeneration possessed long-lasting cytotoxic properties and adopted typical features of senescent immune cells. T cells were intimately associated with the RPE, suggesting transmigration and participating in local micro-inflammation.DiscussionOur data support that activation and accumulation of memory T cells can be considered as a hallmark of early AMD, and that adaptive immunosenescence likely to contribute to the chronic inflammation associated with RPE damage and the progression to large lesions as seen in GA.
Polymorphisms in immunosuppression-related genes are associated with AML
Authors: Li Mingying , Ye Jingjing , Chang Mengyuan , Feng Lei , Liu Tingting , Zhang Di , Wu Yuyan , Ma Yuechan , Meng Guangqiang , Ji Chunyan , Sun Tao 
Published: February 2025

BackgroundAcute myeloid leukemia (AML) is a hematologic malignancy with poor overall survival (OS). The immunosuppressive microenvironment significantly impacts AML development and chemoresistance. Despite new immunotherapeutic strategies entering standard clinical care for various tumors, progress in AML remains poor. Multi-omics analyses, such as single-cell transcriptomics, have revealed many potential new targets to improve AML prognosis from an immunological perspective.MethodsDNA from 307 AML patients and 316 healthy individuals were extracted. We detected nine single nucleotide polymorphisms (SNPs) in five immunosuppression-related genes (CIITA, CD200, CD163, MRC1 and LILRB4) in these samples. SNP genotyping was performed on the MassARRAY platform. We then analyzed the relationship between these SNPs and AML susceptibility, treatment response, and prognosis.ResultsOur findings indicated that rs4883263 in the CD163 gene is a protective factor for AML susceptibility and chromosomal karyotype abnormalities. Additionally, rs4883263 in CD163 was related to low PLT count at diagnosis, while rs2272022 in CD200 was protective against low PLT count. rs4780335 in CIITA was associated with high WBC count at diagnosis and worse OS. Furthermore, rs1048801 in LILRB4 was linked to worse AML treatment response, lower OS, and may be an independent prognostic risk factor for AML. Lastly, expressions of CD163, CIITA, LILRB4, and CD200 were higher in AML patients than that in normal controls.ConclusionsOur findings on SNP associations in AML immunosuppression-related genes provide important reference points for predicting treatment outcomes in AML patients.
Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis
Authors: Wu Rong-Rong , Nie Duo-Rui , He Fang-Hui , Li Zhi-Hang , Xu Fei 
Published: February 2025

ObjectivesTo explore the mechanism underlying the effect of Fructus Akebiae (FAE) against hepatic fibrosis in mice through combined network pharmacology, liver metabolomics, and 16S rDNA analyses of the gut microbiota.MethodsIn this study, we randomly divided mice into the control, model, FAE high-dose, FAE medium-dose, and FAE low-dose groups to analyze the pathological changes in the hepatic fibrosis and levels of the α-SMA, collagen 1, Nuclear Factor Kappa B (NF-κ B), Toll Like Receptor 4 (TLR4). The gut microbiota was analyzed through 16S rDNA sequencing analysis of liver metabolites using liquid chromatography-mass spectrometry. Furthermore, network pharmacology was used to determine the specific molecular regulation mechanism of FAE in hepatic fibrosis treatment.ResultsFAE treatment markedly improved the pathological changes in the hepatic fibrosis. Analysis revealed that FAE administration reversed the carbon tetrachloride (CCl4)-induced dysbiosis by increasing the abundance of Akkermansia and reducing that of Cyanobacteria. Additionally, metabolomic analysis showed that FAE treatment reversed the CCl4-induced metabolic disorders by regulating amino and nucleotide sugar metabolism. Furthermore, correlation analysis showed that Akkermansia and Verrucomicobiota were closely related to D-tolasaccharide and maltotetraose saccharide. Moreover, network pharmacology indicated that FAE might regulate the signaling pathway through the JUN/CASP3/NOS3/PTGS2/HSP90AA1 during treatment.ConclusionFAE may be a promising treatment for hepatic fibrosis, and its protective effects are associated with improvements in the microbiome and metabolic disorders.
Heart disease in pregnancy and adverse outcomes: an umbrella review
Authors: Zhang Jiani , Ren Yuxin , Li Bingjie , Cao Qi , Wang Xiaodong , Yu Haiyan 
Published: February 2025

BackgroundHeart disease in pregnancy encompasses both congenital heart disease and maternal-acquired heart disease, both of which are associated with an increased risk of various adverse outcomes for mothers and their offspring.ObjectiveThe objective of the study was to review and summarize the evidence regarding the association between heart disease in pregnancy and adverse outcomes in mothers and their offspring.Data sourcesA comprehensive search was conducted in Embase, PubMed, Web of Science, and the Cochrane Database of Systematic Reviews from inception to March 2024. The protocol for this review was registered in PROSPERO (CRD42024519144).Study eligibility criteriaThis review included systematic reviews and meta-analyses that examined the association between heart disease in pregnancy and adverse outcomes for mothers and their offspring.Study appraisal and synthesis methodsData were independently extracted by two reviewers. The quality of the systematic reviews and meta-analyses was assessed using the A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR2), while Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to evaluate the strength of the evidence for each outcome.ResultsA total of 12 meta-analyses and systematic reviews were included, which documented 156 adverse outcomes for mothers and 65 adverse outcomes for offspring. Evidence was found for both primary and secondary adverse outcomes. Adverse outcomes for mothers were death, cardiac events (cardiac arrest, heart failure, surgery, arrhythmia, anesthesia or sedation, endocarditis, mitral regurgitation, myocardial infarction, NYHA III–IV, restenosis, syncope, and others), pulmonary events (respiratory failure, pulmonary edema, and respiratory support), embolism, cerebrovascular events, postpartum hemorrhage, arterial events, delivery mode, and hospital stay. Adverse outcomes for offspring were death, pregnancy loss, growth restriction, low birth weight, preterm birth, recurrence, and uncertainty. No publication bias was detected using Egger’s test. The overall AMSTAR 2 confidence rating for the included meta-analyses and systematic reviews was moderate. The majority (55.3%) of the evidence evaluated by GRADE was of low quality, while the remaining outcomes were categorized as having “very low”-quality evidence.ConclusionCurrent evidence links heart disease during pregnancy to adverse maternal outcomes, including death and cardiac, pulmonary, and cerebrovascular events, as well as increased mortality risk for offspring. Many meta-analyses in this field have limitations that raise concerns about their validity, highlighting the need for high-quality prospective studies.