bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms
Authors: Zhang Xiao-Long , Jiang Yang-Yang , Chang Ying-Ying , Sun Yu-Li , Zhou Ying , Wang Yao-Hui , Dou Xiao-Tan , Guo Hui-Min , Ling Ting-Sheng 
Published: February 2025

BACKGROUND
Recently, several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms (R-NENs). However, none of these methods can achieve 100% complete resection (CR), particularly in the vertical direction. Endoscopic full-thickness resection (EFTR) has proven to be an effective method for the treatment of submucosal tumors but is seldom utilized in the eradication of R-NENs.
AIM
To review cases of R-NENs removed using EFTR and to evaluate the safety and efficacy of this technique.
METHODS
This retrospective cohort study enrolled 160 patients with pathologically confirmed R-NENs, including 132 who underwent endoscopic submucosal dissection (ESD) and 28 who underwent EFTR. Lesions were categorized as < 1 cm, 1-2 cm, and > 2 cm in size. CR rate, en bloc resection rate, operation time, and complications were evaluated. Subgroup analyses and follow-up were also performed.
RESULTS
EFTR achieved 100% CR rates for lesions < 1 cm and 1-2 cm, compared with 67.0% and 50.0%, respectively, in the ESD group. En bloc resection and successful removal of the R-NENs were achieved in all patients. Meanwhile, EFTR showed performance comparable to ESD in terms of operation time, hospitalization cost, and postoperative adverse events, except for a one-day longer hospital stay. We also analyzed the invasion depth of R-NENs based on full-thickness specimens. The data showed that 80% of lesions (< 1 cm) and 85.7% of lesions (1-2 cm) had invaded the SM3 level or deeper at the time of resection. For ESD specimens, 46.6% (< 1 cm) and 89.3% (1-2 cm) of lesions had infiltrated more than 2000 μm beneath the muscularis mucosae.
CONCLUSION
EFTR has shown superior performance in the resection of small R-NENs compared with that of ESD.
Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption
Authors: Liu Man , Ji Ying-Lan , Hu Yu-Jie , Su Ying-Xi , Yang Jie , Wang Xiao-Yi , Chu Hong-Yu , Zhang Xue , Dong Shi-Jing , Yang Hui , Liu Yu-Hang , Zhou Si-Min , Guo Li-Ping , Ran Ying , Li Yan-Ni , Zhao Jing-Wen , Zhang Zhi-Guang , Piao Mei-Yu , Zhou Lu 
Published: February 2025

BACKGROUND
Although an association between gut microbiota and cholestatic liver disease (CLD) has been reported, the precise functional roles of these microbes in CLD pathogenesis remain largely unknown.
AIM
To explore the function of gut microbes in CLD pathogenesis and the effects of gut microbiota on intestinal barrier and bile acid (BA) metabolism in CLD.
METHODS
Male C57BL/6J mice were fed a 0.05% 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet for 2 weeks to induce CLD. The sterile liver tissues of mice were then meticulously harvested, and bacteria in homogenates were identified through culture methods. Furthermore, 16S ribosomal DNA sequencing was employed to analyze sterile liver samples collected from eight patients with primary biliary cholangitis (PBC) and three control individuals with hepatic cysts. The functional roles of the identified bacteria in CLD pathogenesis were assessed through microbiota transfer experiments, involving the evaluation of changes in intestinal permeability and BA dynamics.
RESULTS
Ligilactobacillus murinus (L . murinus ) and Lactococcus garvieae (L. garvieae ) were isolated from the bacterial culture of livers from CLD mice. L . murinus was prevalently detected in PBC patients and controls, whereas L. garvieae was detected only in patients with PBC but not in controls. Mice inoculated with L. garvieae exhibited increased susceptibility to experimental CLD, with both in vitro and in vivo indicating that L. garvieae disrupted the intestinal barrier function by down-regulating the expression of occludin and zonula occludens-1. Moreover, L. garvieae administration significantly upregulated the expression of the apical sodium-dependent BA transporter in the terminal ileum and increased serum BA levels.
CONCLUSION
L. garvieae contributes to excessive BA-induced hepatobiliary injury and liver fibrosis by increasing intestinal permeability and enhancing BA reabsorption.
Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes
Authors: Lu Ming-Ying , Wei Yu-Ju , Wang Chih-Wen , Liang Po-Cheng , Yeh Ming-Lun , Tsai Yi-Shan , Tsai Pei-Chien , Ko Yu-Min , Lin Ching-Chih , Chen Kuan-Yu , Lin Yi-Hung , Jang Tyng-Yuan , Hsieh Ming-Yen , Lin Zu-Yau , Huang Chung-Feng , Huang Jee-Fu , Dai Chia-Yen , Chuang Wan-Long , Yu Ming-Lung 
Published: February 2025

BACKGROUND
Insulin resistance, lipotoxicity, and mitochondrial dysfunction contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Mitochondrial dysfunction impairs oxidative phosphorylation and increases reactive oxygen species production, leading to steatohepatitis and hepatic fibrosis. Artificial intelligence (AI) is a potent tool for disease diagnosis and risk stratification.
AIM
To investigate mitochondrial DNA polymorphisms in susceptibility to MASLD and establish an AI model for MASLD screening.
METHODS
Multiplex polymerase chain reaction was performed to comprehensively genotype 82 mitochondrial DNA variants in the screening dataset (n = 264). The significant mitochondrial single nucleotide polymorphism was validated in an independent cohort (n = 1046) using the Taqman® allelic discrimination assay. Random forest, eXtreme gradient boosting, Naive Bayes, and logistic regression algorithms were employed to construct an AI model for MASLD.
RESULTS
In the screening dataset, only mt12361A>G was significantly associated with MASLD. mt12361A>G showed borderline significance in MASLD patients with 2-3 cardiometabolic traits compared with controls in the validation dataset (P = 0.055). Multivariate regression analysis confirmed that mt12361A>G was an independent risk factor of MASLD [odds ratio (OR) = 2.54, 95% confidence interval (CI): 1.19-5.43, P = 0.016]. The genetic effect of mt12361A>G was significant in the non-diabetic group but not in the diabetic group. mt12361G carriers had a 2.8-fold higher risk than A carriers in the non-diabetic group (OR = 2.80, 95%CI: 1.22-6.41, P = 0.015). By integrating clinical features and mt12361A>G, random forest outperformed other algorithms in detecting MASLD [training area under the receiver operating characteristic curve (AUROC) = 1.000, validation AUROC = 0.876].
CONCLUSION
The mt12361A>G variant increased the severity of MASLD in non-diabetic patients. AI supports the screening and management of MASLD in primary care settings.
A gaze into the void: Anticipatory saccades toward prevented events
Authors: Tonn Solveig , Teigeler Janna , Pfister Roland , Gamer Matthias 
Published: February 2025

Abstract
It is an open question how prevented events are represented in the human cognitive system—are they represented like produced events or are they represented in a different format? Here, we propose that seemingly contradictory observations on this question can be unified by assuming different time courses for production and prevention actions. Evidence from two experiments in the anticipatory saccades paradigm supported this model. Specifically, our results suggest that prevented events might be represented like produced events during action selection and execution, whereas their representation dissolves rapidly during action monitoring. In other words, the representation of prevented events reflects a two-step process: An initial affirmative representation is followed by later negation. Preregistrations, data, and analysis scripts for all experiments are available online (https://osf.io/m3veh/).
Pengaruh Pembelajaran Ilmu Tajwid Melalui Media Power Point Terhadap Kemampuan Membaca Al-Qur’an Siswa Pada Mata Pelajaran Al-Qur’an Hadits Di Kelas Viii Mts Hubbul Wathan Cilawu Garut
Authors: Fauziah Hapsah , Lia Lia 
Published: February 2025

Al-Qur’an merupakan sumber utama bagi umat Islam yang berfungsi sebagai petunjuk bagi kehidupan di dunia untuk meraih kehidupan di akhirat.Karena fungsinya tersebut, maka usaha untuk mengkaji dan memahami Al-Qu’ran menjadi persoalan yang sangat penting sehingga pesan-pesan yang terkandung di dalamnya dapat diterima sekaligus dapat dilaksanakan. Selain itu, sudah merupakan suatu keyakinan yang melekat di kalangan umat Islam bahwa Al- Qur’an adalah mukjizat Nabi Muhammad Saw yang kekal dan ajarannya bersifat universal. Penelitian ini bertujuan untuk mendeskripsikan Pengaruh Pembelajaran Ilmu Tajwid Melalui Media Power Point Terhadap Kemampuan Membaca Al-Qur’an Siswa Pada Mata Pelajaran Al-Qur’an Hadits. Metode kuantitatif digunakan dalam penelitian ini karena hasil penelitian disajikan dalam bentuk angka statistik. Jenis penelitian yang dipilih adalah deskriptif korelatif, yaitu penelitian yang bertujuan untuk mengetahui pengaruh atau hubungan antara dua variabel atau lebih. Digunakan untuk mempelajari populasi atau sampel tertentu. Pengumpulan data menggunakan alat penelitian, analisis data statistik yang tujuannya untuk menguji hipotesis yang diberikan. Berdasarkan hasil uji hipotesis didapatkan hasil bahwa terdapat pengaruh Pengaruh Pembelajaran Ilmu Tajwid Melalui Media Power Point Terhadap Kemampuan Membaca Al-Qur’an Siswa Pada Mata Pelajaran Al-Qur’an Hadist menunjukkan pengaruh yang signifikan, hal tersebut dibuktikan dengan hasil analisis korelasi sebesar 46,77% yaitu terletak pada rentang 0,40-0,50 dan termasuk pada kategori tinggi dengan taraf kepercayaan 5%. Dengan demikian Ha diterima dan H0 ditolak
Kata Kunci : Ilmu Tajwid, Kemampuan Membaca Al-Qur’an
Recovering Injected Astrophysics from the LISA Double White Dwarf Binaries
Authors: Delfavero Vera , Breivik Katelyn , Thiele Sarah , O’Shaughnessy Richard , Baker John G. 
Published: February 2025

Abstract
We present the successful recovery of common-envelope ejection efficiency assumed in a simulated population of double white dwarf (DWD) binaries like those which may be observed by the future Laser Interferometer Space Antenna (LISA) mission. We simulate the formation of DWD binaries by using the COSMIC population synthesis code to sample binary formation conditions such as initial mass function, metallicity of star formation, initial orbital period, and initial eccentricity. These binaries are placed in the m12i synthetic Milky Way–like galaxy, and their signal-to-noise ratio (SNR) for the LISA instrument is estimated, considering a Galactic gravitational-wave foreground informed by the population. Through the use of Fisher estimates, we construct a likelihood function for the measurement error of the LISA-bright DWD binaries (≥20 SNR, f
GW ≥ 5 mHz), in their gravitational-wave frequency (f
GW) and chirp mass. By repeating this process for different assumptions of the common-envelope ejection efficiency, we apply Bayesian hierarchical inference to find the best match to an injected astrophysical assumption for a fiducial population model. We conclude that the impact of common-envelope ejection efficiency on the mass-transfer processes involved in DWD formation may be statistically relevant in the future observed LISA population, and that constraints on binary formation may be found by comparing simulated populations to a future observed population.
The Structure of the Molecular Envelope of the Ring Nebula (NGC 6720)
Authors: Kastner Joel H. , Wilner David J. , Ryder Diana , Moraga Baez Paula , De Marco Orsola , Sahai Raghvendra , Wootten Alwyn , Zijlstra Albert 
Published: February 2025

Abstract
We present the first interferometric imaging of molecular line emission from the Ring Nebula, NGC 6720, in the form of Submillimeter Array (SMA) observations of CO J = 2 → 1 emission. The SMA 12CO(2–1) mapping data, with ∼3″ spatial resolution and 2 km s−1 velocity resolution, provide an unprecedentedly detailed, 3D view of the Ring’s clumpy molecular envelope. The emission morphology displayed in the velocity-integrated SMA 12CO(2–1) image closely resembles the morphologies of near-IR H2 and polycyclic aromatic hydrocarbon emission as revealed in recent JWST/NIRCam imaging of NGC 6720. The SMA 12CO(2–1) data demonstrate that the molecular gas is found within a geometrically thin layer that immediately surrounds the ionized gas imaged by Hubble Space Telescope and JWST. A simple, geometric model of the 12CO(2–1) emission data shows that the intrinsic structure of NGC 6720’s molecular envelope closely resembles a truncated, triaxial ellipsoid that is viewed close to pole-on, and that the dynamical age of the molecular envelope is ∼6000 yr. The SMA 12CO(2–1) mapping data furthermore reveal that some of the faint, filamentary features seen projected in the Ring’s interior in JWST imaging are in fact fast-moving polar knots or bullets with radial velocities of ±45–50 km s−1 relative to the systemic velocity, and that the hot progenitor star remnant is positioned at the precise geometric center of the clumpy, ellipsoidal molecular shell. We assert that the Ring’s molecular envelope represents the “fossil” remnant of a relatively sudden mass ejection ∼6000 yr ago that terminated the progenitor star’s asymptotic giant branch (AGB) evolution, and that this ellipsoidal envelope of AGB ejecta was then punctured by fast, collimated polar outflows or jets resulting from interactions between the progenitor and one or more companion stars. Such an evolutionary scenario may describe most if not all molecule-rich, “Ring-like” planetary nebulae.
Rotational Spectrum and Search for Lactonitrile toward Sgr B2(N)
Authors: Insausti A. , Alonso E. R. , Kolesniková L. , Belloche A. , León I. , Mato S. 
Published: February 2025

Abstract
Laboratory experiments on interstellar ice analogs have demonstrated that ice mixtures containing acetaldehyde (CH3CHO) and hydrogen cyanide (HCN) in the presence of ammonia (NH3), water (H2O), or an NH3/H2O mixture allow the formation of the chiral molecule lactonitrile (2-hydroxypropionitrile; CH3CH(OH)CN). These findings place lactonitrile among possible interstellar molecules, especially when its methyl-shortened derivative glycolonitrile and the precursors are known interstellar species. To support the search for lactonitrile in interstellar space, we present measurements under supersonic expansion conditions in the 6–16 GHz frequency range, along with a detailed analysis of its room-temperature rotational spectrum from 75 to 325 GHz. Improved and extended sets of molecular parameters, determined from the newly measured data and selected literature measurements, are obtained for two conformers of lactonitrile, with accuracies conducive to reliable interstellar searches. We report the nondetection of lactonitrile toward the main hot core Sgr B2(N1S), with a column density upper limit 1 order of magnitude higher than the upper limit derived for the related molecule glycolonitrile.
Bilateral Constraints on Proton Lorentz Violation Effects
Authors: He Ping , Ma Bo-Qiang 
Published: February 2025

Abstract
Since the early reports of events beyond the Greisen–Zatsepin–Kuzmin (GZK) cutoff, the investigation of ultrahigh-energy cosmic rays has emerged as a fundamental method for testing Lorentz invariance violation (LV) effects. Recent advances in observational capabilities have resulted in more stringent constraints on LV parameters. This study delves into the potentially anomalous phenomena arising from subluminal and superluminal LV effects, encompassing aspects such as proton decay and atypical threshold behavior of photo-pion production from protons within the GZK region. High-energy proton observations via cosmic rays have imposed stringent constraints on superluminal proton LV effects, while the confirmation of the GZK cutoff has established a robust boundary for the anomalous phenomena associated with subluminal proton LV effects. The research provides rigorously bilateral constraints on proton LV effects from both subluminal and superluminal standpoints.
Quantifying Advantages of a Moving Mesh in Nuclear Hydrodynamics
Authors: Hasenour Dillon L. , Duffell Paul C. 
Published: February 2025

Abstract
Many astrophysical explosions, such as type Ia supernovae, classical novae, and X-ray bursts, are dominated by thermonuclear runaway. To model these processes accurately, one must evolve nuclear reactions concurrently with hydrodynamics. We present an application of the moving mesh technique to this field of computation with the aim of explicitly testing the advantages of the method against the fixed mesh case. By way of traditional Strang splitting, our work couples a 13 isotope nuclear reaction network to a 1D moving mesh, Cartesian geometry hydrodynamics code. We explore three reacting problems: an acoustic pulse, a burning shock, and an advecting deflagration. Additionally, using the shock jump conditions, we semianalytically solve the burning shock problem under the assumption of quick, complete burning with the hope of establishing a useful and easy-to-set-up test problem. Strong moving mesh advantages are found in advecting, deflagrating flame fronts, where the technique dramatically reduces numerical diffusion that would otherwise lead to very fast artificial deflagration.
The Polarization Signatures of the Inverse Cascade in Magnetic Turbulence
Authors: Zhu X. W. , Xie Y. , Lei Z. , Yuan W. Q. , Jin X. X. , Zhao Z. H. , Qiao B. 
Published: February 2025

Abstract
The inverse cascade of magnetic energy from smaller to larger scales is a key physical process for the formation of coherent magnetic fields in many astronomical turbulent systems. Synchrotron radiation polarization, an observable measurement closely related to the magnetic field topology and particle distribution function, is an important and promising tool for diagnosing this highly dynamic process. Here, for the first time, we use the first-principle particle-in-cell simulations to systematically investigate the polarization signatures during the inverse cascade of the magnetic field. We find that the polarization degree (PD) increases rapidly with the increase in the coherent scale of the magnetic field during the inverse transfer and its growth rate is positively correlated with the rate of inverse transfer and could be described by a logarithmic growth formula, and we also identify that the scale with the largest PD variation is coincident with this coherent scale by applying the spatial filter method. In addition, we show that the polarization signature is significantly dependent on the radiated photon energy and the line of sight, with high-energy radiation more sensitive to the increase in the coherent scale of the turbulent magnetic field than low-energy radiation, and the polarization characteristics present significant pitch-angle anisotropy due to the acceleration of particles in the presence of a strong background magnetic field. Our results provide a promising method to explore the astrophysical inverse cascade process and infer the coherent scale of turbulence, which could be validated by astronomical observations in the future.
New Perspective on the Multiple-population Phenomenon in Galactic Globular Clusters from a Wide-field Photometric Survey
Authors: Jang S. , Milone A. P. , Marino A. F. , Tailo M. , Dondoglio E. , Legnardi M. V. , Cordoni G. , Ziliotto T. , Lagioia E. P. , Carlos M. , Mohandasan A. , Bortolan E. , Lee Y.-W. 
Published: February 2025

Abstract
Wide-field photometry of Galactic globular clusters (GCs) has been investigated to overcome limitations from the small field of view of the Hubble Space Telescope in the study of multiple populations. In particular, “chromosome maps” (ChMs) built with ground-based photometry were constructed to identify the first- and second-generation (1G and 2G) stars over the wide field of view. The ChMs allow us to derive the fraction of distinct populations in an analyzed field of view. We present here the radial distribution of the 2G fraction in 29 GCs. The distributions show that all the GCs have either a flat distribution or more centrally concentrated 2G stars. Notably, we find that the fraction of 1G stars outside the half-light radius is clearly bifurcated across all mass range. It implies that a group of GCs with lower 1G fractions (hereafter Group II) have efficiently lost their 1G stars in the outermost cluster regions. In fact, in connection with the trends of the radial distribution, most GCs of Group II have spatially mixed populations, while only less massive GCs in Group I (a group with higher 1G fraction) show that feature. Lastly, we investigate links between these two groups and host cluster parameters. We find that most GCs of Group II are distributed along a broader range of galactocentric distances with smaller perigalactic distances < 3.5 kpc. Besides, by using the Gaia data, it is observed that Group II GCs have higher energy on the integrals of motion diagrams than Group I GCs.
The White Dwarf Pareto: Tracing Mass Loss in Binary Systems
Authors: Shahaf Sahar 
Published: February 2025

Abstract
The white dwarf mass distribution has been studied primarily at two extremes: objects that presumably evolved as single stars, and members of close binaries that likely underwent substantial interaction. This work considers the intermediate separation regime of ∼1 au and demonstrates how binary interaction affects white dwarf masses. The binary mass ratio distribution is utilized for this purpose. Modeled as a truncated Pareto profile, this distribution provides insights into the populations’ properties and evolutionary history. When applied to homogeneous samples of binaries with giant primaries of similar age, the distribution’s shape constrains the fraction of white dwarf companions, the white dwarf mass distribution, and the properties of their progenitors. As a test case, this method is applied to a small spectroscopic sample of binaries in open clusters with red giant primaries and orbital periods between 0.5 and 20 yr. The analysis reveals that white dwarfs in these systems are ∼20% less massive than their isolated counterparts, with a typical mass of ∼0.55 M
⊙. Their progenitors likely lost 80%−85% of their mass, with binary interactions enhancing mass loss by an additional ∼0.2 M
⊙. These findings highlight the utility of this approach for studying binary evolution and improving population models, particularly with future data sets from Gaia and other large-scale surveys.