bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translanguaging: a paradigm shift for ELT theory and practice
Authors: Anderson Jason 
Published: December 2023

AbstractTranslanguaging theory and pedagogy have emerged as central to the recent multilingual turn in educational linguistics and language teaching, including ELT. This article will explore translanguaging from theoretical and practical perspectives, aiming to clarify what it is and is not claiming, and what types of pedagogic practice it advocates, both in its stronger and weaker forms. I argue that a paradigm shift is occurring in the field, parallel with the shift in understanding of the nature of language itself that underpins both translanguaging theory and integrationism in linguistics. Implications for practice in ELT are also explored, including a reorientation concerning the goals of language teaching, a recognition of English as a social construct with traditions of use rather than immutable rules, and a repositioning of the many translingual teachers around the world as the experts at the centre of the multilingual turn that is defining early twenty-first century language pedagogy.
Contrasting the form and strength of pre- and postcopulatory sexual selection in a flatworm
Authors: Marie-Orleach Lucas , Hall Matthew D , Schärer Lukas 
Published: December 2023

Abstract
Sexual traits may be selected during multiple consecutive episodes of selection, occurring before, during, or after copulation. The overall strength and form of selection acting on traits may thus be determined by how selection (co-)varies along different episodes. However, it is challenging to measure pre- and postcopulatory phenotypic traits alongside variation in fitness components at each different episode. Here, we used a transgenic line of the transparent flatworm Macrostomum lignano expressing green fluorescent protein (GFP) in all cell types, including sperm cells, enabling in vivo sperm tracking. We assessed the mating success, sperm-transfer efficiency, and sperm fertilizing efficiency of GFP(+) focal worms in which we measured 13 morphological traits. We found linear selection on sperm production rate arising from pre- and postcopulatory components and on copulatory organ shape arising from sperm fertilizing efficiency. We further found nonlinear (mostly concave) selection on combinations of copulatory organ and sperm morphology traits arising mostly from sperm-transfer efficiency and sperm fertilizing efficiency. Our study provides a fine-scale quantification of sexual selection, showing that both the form and strength of selection can change across fitness components. Quantifying how sexual selection builds up along episodes of selection allows us to better understand the evolution of sexually selected traits.
The evolution of ontogenetic “decision-making” in the wood of a clade of tropical plants
Authors: Petrone-Mendoza Emilio , Benítez Mariana , Lárraga María E , Olson Mark E 
Published: December 2023

Abstract
Greater diversity in functional morphology should be associated with the evolution of greater ontogenetic diversity, an expectation difficult to test in most long-lived wild organisms. In the cells derived from the wood meristem (vascular cambium), plants provide extraordinary systems for reconstructing ontogenies in often long-lived organisms. The vascular cambium produces files of cells from the stem center to the periphery, with each cambial derivative “deciding” which of four cell types it differentiates into. Wood cell files remain in place, allowing tracing of the ontogenetic “decisions” taken throughout the life of a stem. We compared cell files from the Pedilanthus clade (genus Euphorbia), which span a range of growth forms from small trees and shrubs of tropical habitats to desert succulents. Using language theory, we represented wood cell types as “letters” and combinations of cell types in cell files as “words,” allowing us to measure the diversity of decisions based on word frequency matrices. We also used information content metrics to compare levels of predictability in “decision-making.” Our analyses identified a wider array of developmental decisions in woody trees as compared to succulent shrubs, illustrating ways that woody plants provide unparalleled systems for studying the evolution of ontogeny in long-lived, non-model species.
Centromere-proximal suppression of meiotic crossovers in Drosophila is robust to changes in centromere number, repetitive DNA content, and centromere-clustering
Authors: Pazhayam Nila M , Frazier Leah K , Sekelsky Jeff 
Published: December 2023

Abstract
Accurate segregation of homologous chromosomes during meiosis depends on both the presence and the regulated placement of crossovers (COs). The centromere effect, or CO exclusion in pericentromeric regions of the chromosome, is a meiotic CO patterning phenomenon that helps prevent nondisjunction, thereby protecting against chromosomal disorders and other meiotic defects. Despite being identified nearly a century ago, the mechanisms behind this fundamental cellular process remain unknown, with most studies of the Drosophila centromere effect focusing on local influences of the centromere and pericentric heterochromatin. In this study, we sought to investigate whether dosage changes in centromere number and repetitive DNA content affect the strength of the centromere effect, using phenotypic recombination mapping. Additionally, we studied the effects of repetitive DNA function on centromere effect strength using satellite DNA–binding protein mutants displaying defective centromere-clustering in meiotic nuclei. Despite what previous studies suggest, our results show that the Drosophila centromere effect is robust to changes in centromere number, repetitive DNA content, as well as repetitive DNA function. Our study suggests that the centromere effect is unlikely to be spatially controlled, providing novel insight into the mechanisms behind the Drosophila centromere effect.
Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging
Authors: Kramer Philip A , Coen Paul M , Cawthon Peggy M , Distefano Giovanna , Cummings Steven R , Goodpaster Bret H , Hepple Russell T , Kritchevsky Stephen B , Shankland Eric G , Marcinek David J , Toledo Frederico G S , Duchowny Kate A , Ramos Sofhia V , Harrison Stephanie , Newman Anne B , Molina Anthony J A 
Published: December 2023

Abstract
The age-related decline in muscle mitochondrial energetics contributes to the loss of mobility in older adults. Women experience a higher prevalence of mobility impairment compared to men, but it is unknown whether sex-specific differences in muscle energetics underlie this disparity. In the Study of Muscle, Mobility and Aging (SOMMA), muscle energetics were characterized using in vivo phosphorus-31 magnetic resonance spectroscopy and high-resolution respirometry of vastus lateralis biopsies in 773 participants (56.4% women, age 70–94 years). A Short Physical Performance Battery (SPPB) score ≤8 was used to define lower-extremity mobility impairment. Muscle mitochondrial energetics were lower in women compared to men (eg, Maximal Complex I&II OXPHOS: Women = 55.06 ± 15.95; Men = 65.80 ± 19.74; p &lt; .001) and in individuals with mobility impairment compared to those without (eg, Maximal Complex I&II OXPHOS in women: SPPB ≥ 9 = 56.59 ± 16.22; SPPB ≤ 8 = 47.37 ± 11.85; p &lt; .001). Muscle energetics were negatively associated with age only in men (eg, Maximal ETS capacity: R = −0.15, p = .02; age/sex interaction, p = .04), resulting in muscle energetics measures that were significantly lower in women than men in the 70–79 age group but not the 80+ age group. Similarly, the odds of mobility impairment were greater in women than men only in the 70–79 age group (70–79 age group, odds ratio [OR]age-adjusted = 1.78, 95% confidence interval [CI] = 1.03, 3.08, p = .038; 80+ age group, ORage-adjusted = 1.05, 95% CI = 0.52, 2.15, p = .89). Accounting for muscle energetics attenuated up to 75% of the greater odds of mobility impairment in women. Women had lower muscle mitochondrial energetics compared to men, which largely explain their greater odds of lower-extremity mobility impairment.
Systematic Literature Review: Ability of the IBDQ-32 to Detect Meaningful Change in Ulcerative Colitis Health Indicators
Authors: Dubinsky Marla , Rice Alexander , Yarlas Aaron , Hur Peter , Cappelleri Joseph C , Kulisek Nicole , Fahrny Audrey , Bushmakin Andrew , Biedermann Luc 
Published: December 2023

Abstract

Purpose
Previous reviews produced weak evidence regarding the responsiveness of the Inflammatory Bowel Disease Questionnaire (IBDQ-32) to changes in ulcerative colitis (UC) health indicators. This systematic review and meta-analysis provide an updated synthesis on IBDQ-32 responsiveness.

Methods
A systematic literature review identified 11 articles reporting IBDQ-32 responder analyses in randomized control trials, which were included in a random effects meta-analysis, and 15 articles linking IBDQ-32 change to change in UC health indicators, which were summarized narratively. Meta-analysis compared differences between IBDQ-32 responder proportions in efficacious and nonefficacious treatment arms relative to placebo. Linear meta-regression examined the association of treatment efficacy and proportions of IBDQ-32 responders in active treatment compared with placebo.

Results
Meta-analysis showed larger differences in IBDQ-32 response proportions between active treatment and placebo for efficacious treatments (pooled OR, 2.19; 95% CI, 1.83-2.63) than nonefficacious treatments (pooled OR, 1.21; 95% CI, 0.84-1.74; Cochran’s Q[df = 1] = 8.26, P = .004). Meta-regression showed that the magnitude of treatment efficacy positively predicted IBDQ-32 response in active treatments relative to placebo (β = 0.21, P &lt; .001). Moderate to strong correlations were found between change in IBDQ-32 and change in health indicators (eg, patient-reported measures, disease activity, endoscopic indices; correlations, 0.37-0.64 in absolute values). Patients achieving clinical response or remission showed greater change in IBDQ-32 total scores (range, 22.3-50.1 points) and more frequently met clinically meaningful thresholds on the IBDQ-32 than those not achieving clinical response or remission (all P &lt; .05).

Conclusions
The IBDQ-32 is responsive to changes in UC health indicators and disease activity, including in response to efficacious treatment (relative to placebo).
Oral vs Intravenous Discharge Antibiotic Regimens in the Management of Intra-abdominal Abscesses in Penetrating Crohn’s Disease
Authors: Fansiwala Kush , Rusher Alison , Shore Brandon , Herfarth Hans H , Barnes Edward , Kochar Bharati , Chang Shannon 
Published: December 2023

Abstract

Background
Antibiotics are a cornerstone in management of intra-abdominal abscesses in Crohn’s disease (CD). Yet, the optimal route of antibiotic administration is poorly studied. We aimed to compare surgical and nonsurgical readmission outcomes for patients hospitalized for intra-abdominal abscesses from CD discharged on oral (PO) or intravenous (IV) antibiotics.

Methods
Data for patients with CD hospitalized for an intra-abdominal abscess were obtained from 3 institutions from January 2010 to December 2020. Baseline patient characteristics were obtained. Primary outcomes of interest included need for surgery and hospital readmission within 1 year from hospital discharge. We used multivariable logistic regression models and Cox regression analysis to adjust for abscess size, history of prior surgery, history of penetrating disease, and age.

Results
We identified 99 patients discharged on antibiotics (PO = 74, IV = 25). Readmissions related to CD at 12 months were less likely in the IV group (40% vs 77% PO, P = .01), with the IV group demonstrating a decreased risk for nonsurgical readmissions over time (hazard ratio, 0.376; 95% confidence interval, 0.176-0.802). Requirement for surgery was similar between the groups. There were no differences in time to surgery between groups.

Conclusions
In this retrospective, multicenter cohort of CD patients with intra-abdominal abscess, surgical outcomes were similar between patients receiving PO vs IV antibiotics at discharge. Patients treated with IV antibiotics demonstrated a decreased risk for nonsurgical readmission. Further prospective trials are needed to better delineate optimal route of antibiotic administration in patients with penetrating CD.
Factors influencing pharmacists’ roles in preventing prescription and over-the-counter opioid misuse: a systematic review and narrative synthesis
Authors: Offu Ogochukwu Fidelia , Visram Shelina , Rathbone Adam Pattison , Lindsey Laura 
Published: December 2023

Abstract

Background
The prescribing rate of opioids is increasing and is a main contributor to opioid misuse. Community pharmacists can help reduce opioid misuse rates by carrying out prescription and over-the-counter (OTC) opioid misuse prevention services. Understanding the barriers and facilitators to community pharmacists’ involvement has the potential to improve these services.

Objective
To review the literature on the barriers and facilitators of community pharmacists’ involvement in prescription and OTC opioid misuse prevention.

Methods
A systematic review of primary research was carried out in MEDLINE, Embase, Scopus, Web of Science, CINAHL, and APA PsycINFO from January 2022 to March 2022. Narrative synthesis underpinned by the COM-B model was used to analyse findings from the included articles. Studies were included if they used qualitative or mixed methods; published in English and focussed on OTC or prescription opioids.

Results
Ten studies were included in the review. Barriers and facilitators were grouped into individual, environmental, and system-level factors. Based on the COM-B model, these factors were classified as capabilities (knowledge and skill), opportunities (e.g. relationship with prescribers, time), and motivation (pharmacists’ attitude).

Conclusion
Improving pharmacists’ capabilities and opportunities might improve pharmacists’ motivation to offer opioid misuse services. This could improve pharmacists’ behaviour, that is, their role in preventing prescription and OTC opioid misuse. The findings of this review were based on information obtained from primary evidence from qualitative studies; However. further empirical work is needed to identify how pharmacists can be supported.
Debt Crises, Fast and Slow
Authors: Corsetti Giancarlo , Maeng Fred Seunghyun 
Published: December 2023

Abstract
We build a dynamic model where the economy is vulnerable to belief-driven slow-moving debt crises at intermediate debt levels, and rollover crises at both low and high debt levels. Vis-à-vis the threat of slow-moving crises, countercyclical deficits generally welfare-dominate debt reduction policies. In a recession, optimizing governments only deleverage if debt is close to the threshold below which belief-driven slow-moving crises can no longer occur. The welfare benefits from deleveraging instead dominate if governments are concerned with losing market access even at low debt levels. Long bond maturities may fully eliminate belief-driven rollover crises but not slow-moving ones.
Are local retail services an amenity or a nuisance?
Authors: Ghorbani Pooya , Meltzer Rachel 
Published: December 2023

Abstract
We test whether local retail services are considered a nuisance or an amenity and how this distinction is capitalized into residential property values. Using a rich, micro-spatial dataset on property sales transactions and business activity in New York City, we estimate the impact of access to neighborhood retail services on residential sales prices. We construct two instruments to channel supply-side drivers of retail change and to address concerns of endogeneity between changes in retail activity and property values. Results show that retail services that are more frequently consumed and experiential, and are located in relatively more mixed-use neighborhoods are positively capitalized into property values. Residents also pay more to be closer to more diverse retail clusters, and relatively less to be closer to chains. This is true across smaller 1-to-4 family homes as well as larger condos/coops and multi-family rental buildings. The price effects from certain classifications of retail, like restaurants and personal services, are mixed depending on the kind of residential property and the local concentration of the retail. Therefore, the relative strength of the amenity or nuisance effect is very much conditioned on the type of service and the localized neighborhood context.
Stress interactions in cracked media during the closure of prestressed cracks
Authors: Hu Jun-Hua , Li Song-Hui , Cao Cheng-Hao , Cui Rui 
Published: December 2023

Abstract
With the increasing pressure, a crack in a medium will be gradually closed, which is affected by stress interactions. The closing process of parallel cracks under vertical stress is simulated here. The coplanar and stacked cracked models are constructed to analyze the influence of two types of stress interaction on the closing process. The spatial distribution of cracks, demonstrated by numerical experiments, has a significant impact on stress interactions and thus the process of crack closure. The mechanisms underlying the delay of crack closure caused by stress interactions are different for the two models. Furthermore, according to the stress dependence of crack microscopic parameters (crack porosity, aperture, and length of major axis), the process of crack closure can be divided into three stages: the linear deformation stage, the contact stage, and the closure stage. In the first stage, no contact is permitted inside the crack. The shielding effect directly leads to a closure lag, and thus a linear stress dependence of the microscopic crack parameter. In the second stage, the shielding effect determines the increasing rate for the stress dependence of microscopic crack parameters in regularly distributed cracked models. However, for the randomly distributed cracked model, local stress interactions result in the eccentric closure of cracks, and thus the crack closure lag. In the last stage, the crack is closed and stress interactions disappear both in the regularly and randomly distributed models.
The stunted development of unfair competition law in the United States and Canada
Authors: Farley Christine Haight 
Published: December 2023

Abstract
Both the United States and Canada present unfair competition law in a way that is complex and indicative of their kindred beginnings. Sharing a closely paralleled history in the development of unfair competition law, these countries exhibit unique similarities in both substance and approach, likely not found in any other jurisdiction. Born out of English common law, the early trajectory of unfair competition was inextricably linked to trade mark law. Both countries’ legislatures passed ambitious trade mark statutes that created federal regulation of certain areas of unfair competition, while also reserving large areas for the state or provincial legislatures to regulate. Claimants therefore navigate substantial variety in unfair competition protections depending on the cause of action. Even so, obligations under international agreements such as the Paris Convention and interaction with other bodies of law further extend the unfair competition legal landscape. Despite its complexity, the United States and Canada share remarkably similar paths to unfair competition protection. Understanding their history, limited national legislative powers, policy rationales, obligations under international agreements and the interplay between federal and state or provincial law create a rich and multifaceted unfair competition landscape.
Intangible cultural heritage in industrial design
Authors: Shen Yu , Cai Yang-chao , Wang Xin-yue 
Published: December 2023

Abstract
The research aims to develop an original product design using elements of intangible cultural heritage (ICH). It attempts to evaluate the attractiveness of design with elements of ICH in individual countries and on the world stage. A Master of Art History from Korea National University of Arts participated in the analysis and research of ICH objects. Based on the Gmarket online store, the authors conducted fake door testing to determine the attractiveness of this design for consumers. The method of paired comparisons allowed the authors to assess the attractiveness of a design with the ICH elements on the world stage. Following the project’s objectives, the study demonstrated 211 thousand views of the product page with the developed design and 767 thousand views of pages with similar products during one calendar month.
Subcutaneous Anti-inflammatory Therapies to Prevent Burn Progression in a Swine Model of Contact Burn Injury
Authors: Thompson Marc A , Shaffer Lucy , Larson David A , Stavena-Holik Michelle , Nail Carole , Leatherman Logan , Tomblyn Seth , Burnett Luke , Rizzo Julie , Christy Robert J , Kowalczewski Christine J 
Published: December 2023

ABSTRACT

Introduction
If left untreated, burn injuries can deepen or progress in depth within the first 72 hours after injury as a result of increased wound inflammation, subsequently worsening healing outcomes. This can be especially detrimental to warfighters who are constrained to resource-limited environments with delayed evacuation times to higher roles of care and more effective treatment. Preventing this burn progression at the point of injury has the potential to improve healing outcomes but requires a field-deployable therapy and delivery system. Subcutaneous therapies known to treat inflammation delivered local to the wound site may prove to be one such avenue for success.

Materials and Methods
Seven Yorkshire-cross swine received partial-thickness burn injuries using a previously established contact burn model. Each animal received one of the seven therapies: (1) saline, (2) heparin, (3) ibuprofen, (4) erythropoietin, (5) resolvin, (6) rapamycin, and (7) placental extract, all of which are either currently employed or are experimental in field use and indicated to treat inflammation. Treatments were delivered subcutaneously on the day of injury and 24 hours post-injury to simulate a prolonged field care scenario, before potential evacuation. Animals and wound development were observed for 28 days before euthanasia. Throughout the course of the study, wounds were observed macroscopically via non-invasive imaging. Histological analyses provided the critical metric of burn progression. Treatment success criteria were designated as the ability to prevent burn progression past 80% of the dermal depth in two of the three treated wounds, a clinically relevant metric of burn progression.

Results
It was determined that the applied model successfully created reproducible partial-thickness burn injuries in this porcine study. No significant differences with regard to lateral wound size or the rate of lateral wound closure were observed in any treatments. Several treatments including resolvin, rapamycin, ibuprofen, and erythropoietin successfully reduced burn progression to less than 80% of the dermal depth in two of the three wounds, 24 hours after injury.

Conclusions
This report employs an established model of porcine contact burn injury in order to test the ability of local subcutaneous delivery of therapeutics to prevent burn progression at the point of injury, via what is believed to be the inhibition of inflammation. Several treatments successfully prevented burn progression to a full-thickness injury, potentially improving wound healing outcomes in a simulated battlefield scenario. Subcutaneously administered therapies combating burn-induced inflammation at the point of injury may serve as a field-deployable treatment modality to improve warfighter recovery and return to duty.