bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initiation of oral hepatitis C virus treatment: Which barriers are pertinent for ambulatory individuals with a history of illicit substance use? A qualitative interview study
Authors: Barbati Selina , Strasser Johannes , Allemann Samuel S. , Arnet Isabelle 
Published: January 2024

AbstractBackground and AimsThe World Health Organization has set a goal to eradicate hepatitis C virus (HCV) by the year 2030. Nonadherence to HCV treatment has substantial economic implications due to high treatment costs, among others. Barriers to start HCV treatment may be critical. The aim of this study was to assess pertinent barriers to HCV treatment in ambulatory patients with a history of illicit substance use and to compare them to the literature.MethodsBarriers to HCV treatment mentioned by the key risk group (i.e., people who inject drugs) were retrieved from literature through a pragmatic literature search. From 34 published articles, we identified 80 modifiable barriers that were bundled in 23 items within the four topics “Personal difficulties and barriers to treatment,” “Personal motivation to be treated,” “Knowledge about the disease,” and “Received information about the medicine.” In‐depth semistructured interviews were performed face‐to‐face with ambulatory patients from the University Psychiatric Clinics in Basel, Switzerland. Transcripts were coded inductively.ResultsInterviews were performed with seven individuals (mean age: 48.3 years; range: 38–63 years; one woman) treated with oral direct‐acting antivirals between 2014 and 2022. Thirteen barriers to start HCV treatment were mentioned that corresponded to the five categories: information, attitudes, swallowing difficulties, social environment, and unfavorable lifestyle. The barrier “swallowing difficulties” emerged exclusively from the statements provided by the interviewees.ConclusionBarriers to the initiation of HCV treatment indicated by our interviewees clearly differed from the literature. Notably, the challenge of swallowing medicines may be particularly relevant for physicians prescribing and pharmacists dispensing HCV medication.
Modern medical services, a double‐edged sword manages symptoms, but accumulates genetic background of cardiovascular diseases: A cross populational analysis of 217 countries
Authors: You Wenpeng , Henneberg Maciej 
Published: January 2024

AbstractBackground and AimsThrough reduced natural selection, measured with Biological State Index (Ibs), modern medicine enables most people to survive well beyond the reproductive lifespan leading to deleterious gene accumulation in population. This study explored the role of reduced natural selection in increasing cardiovascular disease (CVD) incidence worldwide.MethodsCountry‐specific estimates of CVD incidence and the index of reduced natural selection were captured for analysis of their correlation. Aging, affluence, obesity prevalence, and urbanization were considered as the potential confounders in the analyses.ResultsWorldwide, Ibs was significantly correlated with CVD incidence in the bivariate correlation analyses. This relationship remains when the contributing effects from aging, affluence, obesity prevalence, and urbanization are removed in partial correlation model. Multiple linear regression (enter) shows that Ibs is a significant predictor of CVD incidence. Stepwise multiple linear regression selects Ibs as the variable having the second greatest influence on CVD incidence after ageing. Ibs showed a significantly greater correlation with CVD incidence in low‐ and middle‐income countries (LMICs) than in high‐income countries.ConclusionWorldwide, through reducing natural selection, the side effects of healthcare services may have been partially contributing to the increase of CVD incidence worldwide with special regard to LMICs.
m5C regulator‐mediated methylation modification patterns and tumor microenvironment infiltration characteristics in acute myeloid leukemia
Authors: Wen Qiang , Wang ShouJun , Hong Lili , Shen Siyu , He Yibo , Sheng Xianfu , Zhuang Xiaofen , Chen Shiliang , Wang Ying , Zhuang Haifeng 
Published: January 2024

AbstractBackgroundRecently, many studies have been conducted to examine immune response modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m5C) modification on tumor microenvironment (TME) of acute myeloid leukemia (AML) is still unknown at present.MethodsWe assessed the patterns of m5C modification among 417 AML cases by using nine m5C regulators. Thereafter, we associated those identified modification patterns with TME cell infiltration features. Additionally, stepwise regression and LASSO Cox regression analyses were conducted for quantifying patterns of m5C modification among AML cases to establish the m5C‐score. Meanwhile, we validated the expression of genes in the m5C‐score model by qRT‐PCR. Finally, the present work analyzed the association between m5C‐score and AML clinical characteristics and prognostic outcomes.ResultsIn total, three different patterns of m5C modification (m5C‐clusters) were identified, and highly differentiated TME cell infiltration features were also identified. On this basis, evaluating patterns of m5C modification in single cancer samples was important for evaluating the immune/stromal activities in TME and for predicting prognosis. In addition, the m5C‐score was established, which showed a close relation with the overall survival (OS) of test and training set samples. Moreover, multivariate Cox analysis suggested that our constructed m5C‐score served as the independent predicting factor for the prognosis of AML (hazard ratio = 1.57, 95% confidence interval = 1.38–1.79, p < 1e−5).ConclusionsThis study shows that m5C modification may be one of the key roles in the formation of diversity and complexity of TME. Meanwhile, assessing the patterns of m5C modification among individual cancer samples is of great importance, which provides insights into cell infiltration features within TME, thereby helping to develop relevant immunotherapy and predict patient prognostic outcomes.
An endoscopic approach providing near‐infrared laser‐induced coagulation with accurate depth limits
Authors: Turker‐Burhan Merve , Ellidokuz Ender Berat , Bagriyanik Husnu Alper , Tozburun Serhat 
Published: January 2024

AbstractThis article investigates an endoscopic approach that utilizes negative pressure to achieve laser‐induced thermal coagulation limited to the esophageal wall's mucosal and superficial submucosal layers. The study was built upon a series of studies combining numerical simulation based on the Monte‐Carlo technique and ex vivo porcine tissue experiments, including apparatus design and histology analysis. An endoscopy apparatus was developed using 3D printing to validate the tissue stretching‐based approach. A fiber‐pigtailed diode was used as the near‐infrared source, emitting 208.8 W/cm2 laser irradiance at 1.5 μm. Simulation results suggested that the approach successfully created a local heat well to prevent residual thermal effects (>65°C) from penetrating the deeper submucosal layer. Histology analysis of ex vivo tissues showed that at a fluence of 5.22 kJ/cm2, the depth of thermal coagulation was reduced by half compared to the control. With further preclinical studies, including endoscopy apparatus design, the approach can be applied to the larger esophageal surface.
Actin filament‐associated protein 1‐antisense RNA1 promotes the development and invasion of tongue squamous cell carcinoma via the AFAP1‐AS1/miR‐133a‐5p/ZIC2 axis
Authors: Tang Mingming , Wu Hao , Zhang Huaiqin , Xu Xinjiang , Jiang Bin , Chen Qingwen , Wei Yingze , Qian Hongyan , Han Liang 
Published: January 2024

AbstractBackgroundThe present study aimed to explore the biological role and underlying mechanism of the long non‐coding RNA actin filament‐associated protein 1‐antisense RNA1 (lncRNA AFAP1‐AS1) in the progression of tongue squamous cell carcinoma (TSCC).MethodsA quantitative reverse transcriptase‐PCR (RT‐qPCR) was conducted to assess relative levels of the miR‐133a‐5p, lncRNAs AFAP1‐AS1 and zinc finger family member 2 (ZIC2) in TSCC cell lines and specimens, whereas ZIC2 protein levels were measured using western blotting. After modifying the levels of expression of lncRNA AFP1‐AS1, miR‐133a‐5p and ZIC2 using lentivirus or plasmid transfection, we examined AKT/epithelial–mesenchymal transition signaling pathway alterations, in vivo carcinogenesis of TSCC in nude mice and in vitro malignant phenotypes. A dual‐luciferase reporter assay was conducted to confirm the targeting relationship between ZIC2 and miR‐133a‐5p, as well as between miR‐133a‐5p and lncRNA AFAP1‐AS1. Based on The Cancer Genome Atlas (TCGA) database, we additionally validated AFP1‐AS1. The potential biological pathway for AFP1‐AS1 was investigated using gene set enrichment analysis (GSEA). We also evaluated the clinical diagnostic capacities of AFP1‐AS1 and clustered the most potential biomarkers with the Mfuzz expression pattern. Finally, we also made relevant drug predictions for AFP1‐AS1.ResultsIn TSCC cell lines and specimens, lncRNA AFAP1‐AS1 was upregulated. ZIC2 was upregulated in TSCC cells as a result of lncRNA AFAP1‐AS1 overexpression, which also promoted TSCC cell migration, invasion, viability, and proliferation. Via the microRNA sponge effect, it was found that lncRNA AFAP1‐AS1 could upregulate ZIC2 by competitively inhibiting miR‐133a‐5p. Interestingly, knockdown of ZIC2 reversed the biological roles of lncRNA AFAP1‐AS1 with respect to inducing malignant phenotypes in TSCC cells. In addition, in vivo overexpression of lncRNA AFAP1‐AS1 triggered subcutaneous tumor growth in nude mice implanted with TSCC cells and upregulated ZIC2 in the tumors. The TCGA database findings revealed that AFAP1‐AS1 was significantly upregulated in TSCC specimens and had good clinical diagnostic value. The results of GSEA showed that peroxisome proliferator‐activated receptor signaling pathway was significantly correlated with low expression of AFP1‐AS1. Finally, the results of drug prediction indicated that the group with high AFAP1‐AS1 expression was more sensitive to docetaxel, AZD4547, AZD7762 and nilotinib.ConclusionsThe upregulation of lncRNA AFAP1‐AS1, which increases TSCC cell viability, migration, proliferation and invasion via the AFAP1‐AS1/miR‐133a‐5p/ZIC2 axis, aids in the progression of TSCC.
Rates of breast reconstruction uptake and attitudes toward breast cancer and survivorship among south asians: A literature review
Authors: Sarkar Prottusha , Huffman Kristin N. , Williams Tokoya , Deol Avneet , Zorra Isabella , Adam Tarifa , Donaldson Rachel , Qureshi Umer , Gowda Karan , Galiano Robert D. ,   other members of the Galiano Lab Collaborative Group
Published: January 2024

AbstractOur aim in this review was to ascertain rates of breast reconstruction among South Asian patients and identify attitudes towards breast cancer, survivorship, and breast reconstruction. Mastectomy rates for South Asian patients ranged from 52% to 77% and reconstruction following mastectomy varied from 0% to 14%. A negative perception of cancer, fears of social isolation, and taboos around breasts can prevent South Asian women from receiving surgical care after a breast cancer diagnosis.
Lessons from two series by physicians and caregivers' self‐reported data in DDX3X‐related disorders
Authors: Ruault Valentin , Burger Pauline , Gradels‐Hauguel Johanna , Ruiz Nathalie ,   Xtraordinaire, Jamra Rami Abou , Afenjar Alexandra , Alembik Yves , Alessandri Jean‐Luc , Arpin Stéphanie , Barcia Giulia , Bendová Šárka , Bruel Ange‐Line , Charles Perrine , Chatron Nicolas , Chopra Maya , Conrad Solène , Daire Valérie Cormier , Cospain Auriane , Coubes Christine , Coursimault Juliette , Delahaye‐Duriez Andrée , Doco Martine , Dufour William , Durand Benjamin , Engel Camille , Faivre Laurence , Ferroul Fanny , Fradin Mélanie , Frenkiel Hélène , Fusco Carlo , Garavelli Livia , Garde Aurore , Gerard Bénédicte , Germanaud David , Goujon Louise , Gouronc Aurélie , Ginglinger Emmanuelle , Goldenberg Alice , Hancarova Miroslava , Havlovicová Markéta , Heron Delphine , Isidor Bertrand , Marçais Nolwenn Jean , Keren Boris , Koch‐Hogrebe Margarete , Kuentz Paul , Lamure Victoria , Lebre Anne‐Sophie , Lecoquierre François , Lehman Natacha , Lesca Gaetan , Lyonnet Stanislas , Martin Delphine , Mignot Cyril , Neuhann Teresa M. , Nicolas Gaël , Nizon Mathilde , Petit Florence , Philippe Christophe , Piton Amélie , Pollazzon Marzia , Prchalová Darina , Putoux Audrey , Rio Marlène , Rondeau Sophie , Rossi Massimiliano , Sabbagh Quentin , Saugier‐Veber Pascale , Schmetz Ariane , Steffann Julie , Thauvin‐Robinet Christel , Toutain Annick , Them Frederic Tran Mau , Trimarchi Gabriele , Vincent Marie , Vlčková Markéta , Wieczorek Dagmar , Willems Marjolaine , Yauy Kevin , Zelinová Michaela , Ziegler Alban ,   GENIDA Project, Chaumette Boris , Sadikovic Bekim , Mandel Jean‐Louis , Geneviève David 
Published: January 2024

AbstractIntroduction and MethodsWe report two series of individuals with DDX3X variations, one (48 individuals) from physicians and one (44 individuals) from caregivers.ResultsThese two series include several symptoms in common, with fairly similar distribution, which suggests that caregivers' data are close to physicians' data. For example, both series identified early childhood symptoms that were not previously described: feeding difficulties, mean walking age, and age at first words.DiscussionEach of the two datasets provides complementary knowledge. We confirmed that symptoms are similar to those in the literature and provides more details on feeding difficulties. Caregivers considered that the symptom attention‐deficit/hyperactivity disorder were most worrisome. Both series also reported sleep disturbance. Recently, anxiety has been reported in individuals with DDX3X variants. We strongly suggest that attention‐deficit/hyperactivity disorder, anxiety, and sleep disorders need to be treated.
Ecological momentary assessment of pelvic pain and urinary urgency variability in urologic chronic pelvic pain syndrome and their association with illness impact and quality of life: Findings from the multidisciplinary approach to the study of chronic pelvic pain symptom patterns study
Authors: Erickson Bradley A. , Griffith James W. , Wensheng Guo , Mengying You , Herman Ted , Bradley Catherine S. , Quentin Clemens J. , Farrar John T. , Gupta Priyanka , Kreder Karl J. , Henry Lai H. , Naliboff Bruce D. , Newman Diane K. , Rodriguez Larissa V. , Spitznagle Theresa , Sutcliffe Siobhan , Sutherland Suzette E. , Taple Bayley J. , Richard Landis J. 
Published: January 2024

AbstractPurposeThis study tested the hypothesis that ecological momentary assessment (EMA) of pelvic pain (PP) and urinary urgency (UU) would reveal unique Urologic Chronic Pelvic Pain Syndrome (UCPPS) phenotypes that would be associated with disease specific quality of life (QOL) and illness impact metrics (IIM).Materials and MethodsA previously validated smart phone app (M‐app) was provided to willing Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) participants. M‐app notifications were sent 4‐times daily for 14 days inquiring about PP and UU severity. A clustering algorithm that accounted for variance placed participants into PP and UU variability? clusters. Associations between clusters and QOL and IIM were then determined.ResultsA total of 204 participants enrolled in the M‐app study (64% female). M‐app compliance was high (median 63% of surveys). Cluster analysis revealed k = 3 (high, low, none) PP clusters and k = 2 (high, low) UU clusters. When adjusting for baseline pain severity, high PP variability, but not UU variability, was strongly associated with QOL and IIM; specifically worse mood, worse sleep and higher anxiety. UU and PP clusters were associated with each other (p < 0.0001), but a large percentage (33%) of patients with high PP variability had low UU variability.ConclusionsPP variability is an independent predictor of worse QOL and more severe IIM in UCPPS participants after controlling for baseline pain severity and UU. These findings suggest alternative pain indices, such as pain variability and unpredictability, may be useful adjuncts to traditional measures of worst and average pain when assessing UCPPS treatment responses.
Incidence and influencing factors of urinary incontinence in stroke patients: A meta‐analysis
Authors: Wang Shuyao , Kang Hua , Wang Qingyuan , Wang Dan , Hu Lizi , Kou Jiaojiao , Yang Zijiang 
Published: January 2024

AbstractBackgroundThe incidence of stroke in China ranks first in the world and is the leading cause of death and disability in adults. Urinary incontinence is an independent risk factor leading to poor prognosis of stroke. However, studies on the incidence of urinary incontinence in stroke patients and its influencing factors are different, fluctuate greatly, and there is no unified basis.ObjectiveTo quantitatively analyze the incidence of urinary incontinence in stroke patients and its related influencing factors, and further make public health strategic decisions to reduce the occurrence of adverse outcomes.MethodsComputer searches were conducted in PubMed, Medline, Web of Science, Cochrane Library, Embase, CLNAHL Complete, China National Knowledge Infrastructure (CNKI), Chinese Biomedical database(CBM), Wan Fang Database, VIP Database, observational studies such as cohort studies, case‐control studies or cross‐sectional studies on the incidence or influencing factors of urinary incontinence in stroke patients from the establishment of the database to the publication in August 2023. Studies selection, quality evaluation and data extraction were conducted independently by two researchers according to the established search strategy. Stata 14.0 statistical software was used for meta‐analysis.ResultsA total of 21 manuscripts were included, with a cumulative sample size of 7327 cases, including 2887 patients with urinary incontinence. Meta‐analysis results showed that the incidence of urinary incontinence in stroke patients was 38% [95% confidence interval (34%, 41%)], including married patients and lacunar infarction were the protective factors for urinary incontinence in stroke patients, while age, chaperone, low educational level, chronic cough, lesion sites (parietal lobe, frontal lobe, and temporal lobe), stroke type (cerebral hemorrhage, subarachnoid hemorrhage and cerebral hemorrhage complicated with subarachnoid hemorrhage), dysfunction (aphasia dyslexia, dysphagia, eye movement abnormalities, leg muscle disorders), post‐stroke depression, the higher the NIHSS score, the lower the Bachmann index (BI) score, OCSP classification (total anterior circulation infarction) and other 11 items were risk factors for urinary incontinence in stroke patients.ConclusionThe incidence of urinary incontinence in stroke patients is 38%. Marriage and lacunar infarction are the protective factors of urinary incontinence. Age, carer, low educational level, chronic cough, lesion site (parietal, frontal and temporal lobes), stroke type (cerebral hemorrhage, subarachnoid hemorrhage, cerebral hemorrhage combined with subarachnoid hemorrhage), dysfunction (aphasia and dysarthria syndrome, dysphagia, eye movement abnormalities, leg muscle disorders), post‐stroke depression, and higher NIHSS score, Lower BI score and OCSP classification (total anterior circulation infarction) were risk factors for urinary incontinence in stroke patients.
New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2022
Authors: Wu Franklin M. , Gorelik Daniel , Brenner Michael J. , Takashima Masayoshi , Goyal Amit , Kita Ashley E. , Rose Austin S. , Hong Robert S. , Abuzeid Waleed M. , Santa Maria Peter , Al‐Sayed Ahmed A. , Dunham Michael E. , Kadkade Prajoy , Schaffer Scott R. , Johnson Alan W. , Eshraghi Adrien A. , Samargandy Shireen , Morrison Robert J. , Weissbrod Philip A. , Mitchell Margaret B. , Rabbani Cyrus C. , Futran Neil , Ahmed Omar G. 
Published: January 2024

AbstractObjectiveTo review new drugs and devices relevant to otolaryngology approved by the Food and Drug Administration (FDA) in 2022.Data SourcesPublicly available FDA data on drugs and devices approved in 2022.Review MethodsA preliminary screen was conducted to identify drugs and devices relevant to otolaryngology. A secondary screen by members of the American Academy of Otolaryngology–Head and Neck Surgery's (AAO‐HNS) Medical Devices and Drugs Committee differentiated between minor updates and new approvals. The final list of drugs and devices was sent to members of each subspecialty for review and analysis.ConclusionA total of 1251 devices and 37 drugs were identified on preliminary screening. Of these, 329 devices and 5 drugs were sent to subspecialists for further review, from which 37 devices and 2 novel drugs were selected for further analysis. The newly approved devices spanned all subspecialties within otolaryngology. Many of the newly approved devices aimed to enhance patient experience, including over‐the‐counter hearing aids, sleep monitoring devices, and refined CPAP devices. Other advances aimed to improve surgical access, convenience, or comfort in the operating room and clinic.Implications for PracticeMany new devices and drugs are approved each year to improve patient care and care delivery. By staying up to date with these advances, otolaryngologists can leverage new innovations to improve the safety and quality of care. Given the recent approval of these devices, further studies are needed to assess long‐term impact within the field of otolaryngology.
Poly (vinyl alcohol) based carbon nanofibers as freestanding anodes for lithium‐ion batteries
Authors: Pampal Esra Serife , Stojanovska Elena , Kilic Ali , Demir Ali 
Published: January 2024

AbstractIn this study, we investigated the iodination process for the preparation of water‐soluble polyvinyl alcohol (PVA)‐based carbon nanofibers (CNFs) and their electrochemical properties. Iodinated nanofibers were carbonized at different temperatures (600°C, 800°C) under an argon (Ar) atmosphere. Morphology and physical properties of fiber mats were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and thermogravimetric analysis (TGA), while electrical conductivity measurements were done using four probes. As a freestanding anode in half‐cell lithium batteries, the CNFs were prepared by electrospinning of PVA and PVA–CNT blend, which was exposed to iodine vapor at various temperatures (60, 80, and 100°C). Iodine vapor treatment at 80°C and subsequent carbonization at 800°C provided a 29% carbon yield. The resulting CNT‐containing optimized CNFs exhibited superior flexibility, electrical conductivity (2.16 S/cm), and handleability, making them a promising, binder‐free environmentally friendly carbon source for lithium‐ion batteries with high capacity (672 mAh/g at 50 mA/g). The study clearly showed that PVA might be an alternative precursor for the production of carbon micro‐ and nanofibers.Highlights
Anodic performance of PVA‐based carbon nanofibers was analyzed.
PVA precursor offers economic and environmental option for binder‐free electrodes.
PVA–CNT composite nanofibers with optimized iodination and carbonization time identified as a promising high carbon yield carbon source for lithium‐ion batteries.
CNT‐containing optimized carbon nanofibers exhibited superior flexibility and electrical conductivity (2.16 S/cm).
Freestanding fiber anodes exhibited a higher capacity of 672 mAh/g, at 50 mA/g compared to conventional graphite anode (372 mAh/g).