bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levantine and Arabian Travels:European and American Experiences (Part 1)*
Authors: Obeidat Marwan , Mumayiz Ibrahim 
Published: January 2024

European and American travel experiences in the Levant and Arabia serve, in the last analysis, as a treatise on the psychology of human quest rather than mere records of individual itineraries. During the Crusades, this quest was prompted by the desire for religious fulfillment augmented by the innate European craving for the mysterious and the exotic. The Renaissance evinced a consuming curiosity about Islam's holy cities in Arabia; a curiosity that had been fuelled by the Crusader wars against the Muslim enemy. European travel to Arabia, across the centuries up to the nineteenth, was a hazardous adventure into a mysterious and forbidden land; an adventure which whetted European craving for travel. By the nineteenth century, Levantine and Arabian travel had developed into a science in which experts - Egyptologists, and other archaeologists, Arabists, sociologists, and Biblical scholars practiced their respective fields of specialization. The early twentieth century saw the rise of a new type of travel writer; that of the archaeologist/political officer, whose activities, for the first time since the Middle Ages, were part and parcel of British imperial interests. Arabian travel, in the traditional sense, came to an end in the 1950's, with the completion of the exploration of the Empty Quarter. European and American travel experiences in the Levant and Arabia, as surveyed in this article, being a prototype of a treatise on quest psychology, serve, hopefully, to invite yet further research on the psychology of quest..
Hubungan lama penggunaan gadget terhadap interaksi sosial pada anak pra sekolah di Tk. Tut wuri handayani kecamatan parangloe kabupaten gowa.
Authors: Hamdayani Hamdayani , Sainah Sainah 
Published: January 2024

Tujuan: Untuk menganalisis secara mendalam Hubungan Lama Penggunaan Gadget Terhadap Interaksi Sosial Pada Anak Pra Sekolah di Tk. Tut Wuri Handayani Kecamatan Parangloe Kabupaten Gowa 2019. Metode Penelitian: Jenis penelitian kuantitatif dengan adalah rancangan penelitian analitik deskriptif korelasi dengan pendekatan cross sectional yang merupakan penelitian yang menekankan pada waktu pengukuran observasi data variabel independen dan dependen di nilai hanya satu kali pada satu saat dan lembar Kuesioner.Hasil: Didapatkan hasil penelitian sebagai berikut: Adanya Hubungan lama penggunaan gadget terhadap interaksi sosial anak pra sekolah dengan nilai sig.(2-tailed) 0,000. setelah dilakukan perhitungan statistik dengan uji spearman’s rho, didapatkan hasil sebesar 0,000 lebih kecil 0,01.Implikasi penelitian bahwa masih ada beberapa responden yang kurang interaksi sosialnya karena penggunaan gadget. Rekomendasi: perlu adanya peran orang tua utuk selalu memperhatikan pola aktivitas anak dan juga dukungan keluarga untuk berperan aktif dalam mencapai interak sisosial yang baik pada anak. Kata kunci: : Anak Pra Sekolah, Gadget, Interaksi Sosial
ANALISIS ASUHAN KEPERAWATAN PADA IBU PREEKLAMPSIA DENGAN NYERI AKUT MENGGUNAKAN INTERVENSI TERAPI MUROTTAL SURAH MARYAM
Authors: Nurhidayah Nurhidayah , Arbianingsih Arbianingsih , Muthaharah Muthaharah , Wahab BR A.M Abd. 
Published: January 2024

Preeklampsia adalah salah satu komplikasi kehamilan yang terjadi karena tekanan darah terlalu tinggi semasa mengandung bayi. Nyeri berdasarkan International Association for the Study of Pain (IASP) adalah sensori tidak nyaman dan pengalaman emosional yang sangat berhubungan dengan potensial kerusakan jaringan atau terdapat kerusakan jaringan yang nyata.Tindakan nonfarmakologis yang dapat diberikan pada pasien yang mengalami nyeri akut salah satunya adalah dengan melakukan Terapi Murottal Surah Maryam. Tujuan: Untuk mengetahui analisis asuhan keperawatan pada ibu preeklampsia dengan nyeri akut menggunakan intervensi terapi murottal Surah Maryam di Puskesmas Bajeng Kabupaten Gowa. Metode Penelitian: Metode yang digunakan adalah studi kasus dengan teknik pengumpulan data melalui observasi, wawancara dan pemeriksaan fisik. Hasil: Setelah diberikan intervensi pemberian terapi murottal Surah Maryam selama 3 hari pada ibu yang mengalami preeklampsia dengan nyeri akut, didapatkan hasil bahwa terjadi penurunan tingkat nyeri secara perlahan. Sehingga dapat disimpulkan bahwa pemberian terapi murottal surah Maryam efektif menurunkan nyeri. Implikasi penelitian: Berdasarkan hasil evaluasi pada studi kasus yang dilakukan dapat memberikan respon berupa ketenangan emosional, dan relaksasi sehingga pasien mampu mengontrol nyeri. Rekomendasi: Referensi tambahan pemberian asuhan keperawatan dalam keperawatan maternitas dan meningkatkan pencegahan terjadinya Hipertensi dalam kehamilan maupun preeklampsia. Kata kunci: Nyeri; Preeklampsia; Terapi Murottal; Surah Maryam
ANALISIS PENGGUNAAN ALAT PELINDUNG DIRI MENGGUNAKAN HEALTH BELIEF MODEL PADA PETANI DI KECAMATAN PATALASSANG, KABUPATEN GOWA
Authors: Juliani Arni , Salcha1 Muhammad Akbar 
Published: January 2024

Pendahuluan : Petani merupakan profesi dengan potensi bahaya yang tinggi, baik dari segi keselamatan dan kesehatan seperti keracunan pestisida, luka akibat terkena peralatan kerja dan potensi bahaya lainnya. Kurangnya penggunaan APD pada petani penyemprot akan meningkatkan risiko keracunan akut pada petani. Tujuan penelitian : untuk menganalisis dimensi utama dari health belief model yang paling berpengaruh dengan penggunaan APD pada petani. Metode Penelitian : Penelitian ini merupakan observasional analitik dengan pendekatan cross sectional study dan analisis multivariat digunakan untuk mengetahui dimensi utama yang paling berpengaruh dengan penggunaan APD pada petani dengan menggunakan analisis regresi logistik. Populasi dalam penelitian ini adalah seluruh petani di Dusun Saile, Kabupaten Gowa yang jumlahnya 76 orang. Tehnik penarikan sampel menggunakan exchaustive sampling yang mana keseluruhan populasi dijadikan sampel penelitian. Hasil penelitian : Penelitian ini menunjukkan bahwa variabel perceived severity (p = 0,001) merupakan dimensi yang paling berpengaruh terhadap penggunaan APD pada petani di Dusun Saile. Saran : Diharapkan kepada petani agar selalu menerapkan perilaku aman dalam hal ini penggunaan APD, terutama dalam proses penggunaan pestisida selama bekerja. Perlu perhatian khusus dari pemerintah setempat dalam hal sosialisasi tentang penggunaan APD kepada para petani agar dapat terbentuk persepsi yang baik sehingga perilaku aman dalam bekerja dapat terbentuk di petani
Treatment of severe pressure ulcers with protein-enriched filtered platelet-rich plasma (PEFPRP): a possible management
Authors: Mazzucco Laura , Balbo Valeria , Zingarelli Enrico Maria , Desilvestri Manuela , Marchioni Manuela , Perrero Luca , Pollis Francesca , Varvello Ilaria 
Published: January 2024

Background: Biological dressings with non-transfusion blood components are among the treatments available for pressure ulcers (PUs). Biological dressings contain active concentrated pro-regenerative molecules that can modify and switch off local inflammatory pathways. This re-establishes the physiological homing, which results in healing. In our study, we used a biological component obtained by ultrafiltration of plasma-platelet concentrate: protein-enriched filtered platelet-rich plasma (PEFPRP) with a higher platelet and higher plasma protein concentration. We tested whether treatment with PEFPRP could improve healing in advanced-stage pressure ulcers with a large surface area. All the patients in this study had a surgical indication but were not able to undergo surgery for various reasons.Materials and methods: Ten patients with severe neurological disability and advanced-stage sacral pressure ulcers were treated with allogenic PEFPRP. The mean lesion surface area at T0 was 13.4 cm2 ( ± 9.8 SD). PEFPRP was derived from allogenic plasma-platelet apheresis that had been pre-ultrafiltered with a ProSmart™ filter (Medica, Italy) to obtain a concentration after filtration of the plasma protein (12–16 g/dL) and platelet (1–1.2 x 106 microL).Results and Conclusion: All cases showed a reduction in the surface area of the pressure ulcer and in the Pressure Ulcer Scale for Healing (PUSH) score. The mean reduction values at week 6 were as follows: −52% for surface area and −21% for PUSH. Rapid wound healing is fundamental to avoid infections and improve patients’ quality of life. This blood component builds new tissue by creating a new extracellular matrix. This, in turn, promotes rapid restoration of the three-dimensional structure of the tissue necessary for healing deeper wounds. PEFPRP shrinks the PU and improves its morphological features (reducing undermining and boosting granulation tissue). PEFPRP also promotes tissue restoration, obtaining an optimal scar. It is a safe and feasible treatment, and these preliminary results support the use of PEFPRP in the treatment of pressure ulcers. PEFPRP dressings could be integrated in the standard treatment of advanced-stage PU.
Simulated research on distributed hydrological models–a case study of the Daxi Water Basin
Authors: Wang Dacheng , Zhou Yue , Zhang Xiaolei , Liu Yalan , Teng Qizhi , Ma Meihong 
Published: January 2024

Against the backdrop of global climate warming, the issue of flash flood disasters in small watersheds triggered by heavy rainfall is gradually becoming more prominent. Selecting an appropriate hydrological model is crucial for flash flood disaster defense. This article focuses on the Daxi Water Basin in Lianping County, Guangdong Province, as the research area. Firstly, organize the data and subject it to standardization processing. Subsequently, establish the topological relationships within the basin, construct a hydrological model for simulating flood processes in Chinese mountainous regions, and obtain a set of model parameters applicable to the specific basin. The results indicated that: ① the relative errors of flood runoff depth were all less than 7%, with an average of 4.5%; ② the relative errors of peak flow for all events were less than 6%, with an average of 4.2%; ③ peak time errors were all within ±2 h, either earlier or later than the actual peak by 1 h; ④ the Nash-Sutcliffe efficiency coefficient for floods were all greater than 0.8, with an average of 0.86. The research results above will serve as a reference and guidance for flood defense management in the Daxi Water Basin.
The non-linear link between non-high-density lipoprotein to high-density lipoprotein ratio and the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study
Authors: Wang Lanbo , Han Yong , Cao Changchun , Hu Haofei , Li Han 
Published: January 2024

ObjectiveThis study aims to assess the association between the non-HDL-c/HDL-c ratio and stroke risk among middle-aged and older adults participating in the China Health and Retirement Longitudinal Study (CHARLS).MethodsThis study conducted a prospective cohort analysis, enrolling a total of 10,183 participants who met the designated criteria from CHARLS between 2011 and 2012. We then used the Cox proportional-hazards regression model to explore the relationship between baseline non-HDL-c/HDL-c ratio and stroke risk. Using a Cox proportional hazards regression with cubic spline function, we were able to identify the non-linear relationship between the non-HDL-c/HDL-c ratio and stroke occurrence. A series of sensitivity analyses were also carried out.ResultsThe average age of the participants included in this study was 59.16 ± 9.35 years, and 4,735 individuals (46.68%) were male. Over a median follow-up period of 7.0 years, a total of 1,191 people (11.70%) experienced a stroke. Using a Cox proportional hazards regression model that was fully adjusted, we found no statistically significant correlation between the non-HDL-c/HDL-c ratio and the risk of stroke (HR=1.022; 95% CI 0.964, 1.083). Nevertheless, we did observe a non-linear relationship and saturation effect between the non-HDL-c/HDL-c ratio and stroke. Employing a two-piece Cox proportional hazards regression model and a recursive algorithm, we determined an inflection point of 2.685 for the non-HDL-c/HDL-c ratio. In instances where the non-HDL-c/HDL-c ratio fell below 2.685, for every 1-unit decrease in the non-HDL-c/HDL-c ratio, the likelihood of stroke decreased by 21.4% (HR=1.214, 95% CI: 1.039-1.418). In contrast, when the non-HDL-c/HDL-c ratio exceeded 2.685, there was no statistically significant change in the risk of stroke for each unit decrease in the non-HDL-c/HDL-c ratio (HR: 0.967, 95% CI: 0.897-1.042). The consistency of these findings across multiple sensitivity analyses suggests their robustness.ConclusionThis study unveils a non-linear relationship between the non-HDL-c/HDL-c ratio and stroke risk in middle-aged and older adults in China. Specifically, when the non-HDL-c/HDL-c ratio was below 2.685, a significant and clearly positive association with stroke risk was observed. Additionally, maintaining the non-HDL-c/HDL-c ratio below 2.685 could potentially lead to a substantial reduction in the risk of stroke.
Increasing fish biodiversity in high elevation Albertan lakes in response to global environmental change over the past 50 years
Authors: Wu Thomas , Nguyen Thi Nhi , Imrit Mohammad Arshad , Kong Jude , Sharma Sapna 
Published: January 2024

IntroductionThe diversity of freshwater fishes is threatened by multiple environmental stressors, including climate change, alterations in land use, and introduction of non-native species. However, the quantification of temporal biodiversity in freshwater communities is limited. Here, we asked: i) how has alpha (species richness), beta (changes in freshwater species composition), and gamma diversity (total species diversity in a landscape) changed over time for lakes over a 50 year period?; and ii) What are the climatic, land use, and lake morphological drivers associated with higher diversity?MethodsWe assembled a database of fish species occurrence from 20 lakes across subalpine and alpine regions in Alberta from 1970-2019, in addition to lake morphological, climatic, and land use characteristics of the watersheds. ResultsWe observed an overall increase in alpha, beta, and gamma diversity from the 1970s to 2009s. However, all measures of diversity declined from 2010-2019. We found that more lakes and species assemblages were influenced by species gains, rather than species losses (with the exception of the last decade of sampling). DiscussionGenerally, we found that coolwater species were expanding and coldwater fishes were being lost throughout our study lakes. We highlight temporal heterogeneity in fish biodiversity responses to substantial environmental pressures in this region.
Case report: Immune pressure on hematopoietic stem cells can drastically expand glycosylphosphatidylinositol-deficient clones in paroxysmal nocturnal hemoglobinuria
Authors: Shingai Naoki , Mizumaki Hiroki , Najima Yuho , Yamada Yuta , Tran Dung Cao , Haraguchi Kyoko , Toya Takashi , Okuyama Yoshiki , Doki Noriko , Nannya Yasuhito , Ogawa Seishi , Nakao Shinji 
Published: January 2024

IntroductionParoxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disease characterized by intravascular hemolysis, thrombosis, and bone marrow (BM) failure. Although PNH is caused by excessive proliferation of hematopoietic stem cell (HSC) clones with loss of function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA) genes, what drives PNH clones to expand remains elusive.Case descriptionWe present a case of a 26-year-old female who presented with hemolytic anemia, thrombocytopenia, and leukopenia. Flow cytometry analysis of peripheral blood showed that 71.9% and 15.3% of the granulocytes and erythrocytes were glycosylphosphatidylinositol-anchored protein deficient (GPI[-]) cells. The patient was diagnosed with PNH with non-severe aplastic anemia. Deep-targeted sequencing covering 390 different genes of sorted GPI(-) granulocytes revealed three different PIGA mutations (p.I69fs, variant allele frequency (VAF) 24.2%; p.T192P, VAF 5.8%; p.V300fs, VAF 5.1%) and no other mutations. She received six cycles of eculizumab and oral cyclosporine. Although the patient’s serum lactate dehydrogenase level decreased, she remained dependent on red blood cell transfusion. Six months after diagnosis, she received a syngeneic bone marrow transplant (BMT) from a genetically identical healthy twin, following an immune ablative conditioning regimen consisting of cyclophosphamide 200 mg/kg and rabbit anti-thymocyte globulin 10 mg/kg. After four years, the patient’s blood count remained normal without any signs of hemolysis. However, the peripheral blood still contained 0.2% GPI (-) granulocytes, and the three PIGA mutations that had been detected before BMT persisted at similar proportions to those before transplantation (p.I69fs, VAF 36.1%; p.T192P, VAF 3.7%; p.V300fs, VAF 8.6%) in the small PNH clones that persisted after transplantation.ConclusionsThe PNH clones that had increased excessively before BMT decreased, but persisted at low percentages for more than four years after the immunoablative conditioning regimen followed by syngeneic BMT. These findings indicate that as opposed to conventional theory, immune pressure on HSCs, which caused BM failure before BMT, was sufficient for PIGA-mutated HSCs to clonally expand to develop PNH.
Moving beyond fish: working towards integrating human dimensions into sustainable seafood guides from South African perspectives
Authors: Ward Catherine Dale , Pillay Pavitray , Norton Marieke 
Published: January 2024

Traditionally, seafood assessments and subsequent ratings have guided choice and responsible sourcing of sustainable seafood based primarily on environmental concerns, with limited to no consideration to multi-faceted human dimensions that form an integral part of these complex social-ecological systems. For wild-capture marine fisheries around the world, and particularly in developing countries, human dimensions remain underrepresented in sustainability ratings, where the focus has traditionally been on larger, data-rich commercial fishery components that report predominantly on ecological and management considerations. Yet, addressing the diverse and complex nature of marine social-ecological systems remains critical to achieve global sustainable seafood systems that balance ecological and societal needs to benefit both nature and people. This paper champions the integration of human elements into seafood sustainability guides, building on work reviewing how best to integrate human dimensions into traditional seafood assessments under the World Wide Fund for Nature (WWF) – drawing on examples from South Africa. While the paper does not prescribe a blueprint for implementation, this review highlights challenges and opportunities to include human rights violations and small-scale fisheries in existing sustainable seafood guides from a South African perspective. There is a need for sustainability considerations to move beyond fish to better represent how these social-ecological systems feed into oceanic cultural norms and nutrition. This translates to shifting from an ecological focus to include human dimensions to better represent complex marine social-ecological systems and drive equitable change within local and global seafood industries.
The current situation of hereditary angioedema patients in Germany: results of an online survey
Authors: Magerl Markus , Martinez-Saguer Inmaculada , Schauf Lucia , Pohl Sven , Brendel Klaus 
Published: January 2024

IntroductionHereditary angioedema (HAE) is a rare hereditary disease with an estimated prevalence of approximately 1 in 50,000.MethodsAn online survey was performed between January and June 2021 on a total of 99 HAE patients (with 92 of them aged 15 years and older and 7 of them being parents of patients under the age of 15 years). They were asked about their current situation, with a focus on the disease.ResultsThe survey results show that HAE has a strong influence on the patients’ quality of life. In particular, the anxiety and uncertainty of not knowing when a swelling attack will occur is considered burdensome by the patients. In addition, there can be physical problems during an attack (depending on its severity) that severely burden and limit patients in their everyday lives. Only one-third of the patients surveyed stated that no or only very minor physical limitations occurred during their most recent swelling attack. Almost three-quarters of all patients receive regular treatment at an HAE center. The patients are mostly satisfied with the therapy and particularly with long-term prophylactics (LTPs). When an LTP was used, the frequency and severity of the swelling attacks, and their duration, were significantly lower and/or shorter than when no LTP was used.DiscussionDespite the high level of satisfaction with their current medication, 62% of patients expressed a strong/very strong interest in an oral LTP. In the group of patients already using an LTP, 74% reported a strong/very strong interest in an oral medication for long-term prophylaxis. The simplicity and minimal time involved in LTP use are considered beneficial to patients’ quality of life.
Unraveling the genetic evolution of SARS-CoV-2 Recombinants using mutational dynamics across the different lineages
Authors: Ravi Varsha , Shamim Uzma , Khan Md Abuzar , Swaminathan Aparna , Mishra Pallavi , Singh Rajender , Bharali Pankaj , Chauhan Nar Singh , Pandey Rajesh 
Published: January 2024

IntroductionRecombination serves as a common strategy employed by RNA viruses for their genetic evolution. Extensive genomic surveillance during the COVID-19 pandemic has reported SARS-CoV-2 Recombinant strains indicating recombination events during the viral evolution. This study introspects the phenomenon of genome recombination by tracing the footprint of prominent lineages of SARS-CoV-2 at different time points in the context of on-going evolution and emergence of Recombinants.MethodWhole genome sequencing was carried out for 2,516 SARS-CoV-2 (discovery cohort) and 1,126 (validation cohort) using nasopharyngeal samples collected between the time period of March 2020 to August 2022, as part of the genomic surveillance program. The sequences were classified according to the different lineages of SARS-CoV-2 prevailing in India at respective time points.ResultsMutational diversity and abundance evaluation across the 12 lineages identified 58 Recombinant sequences as harboring the least number of mutations (n = 111), with 14 low-frequency unique mutations with major chunk of mutations coming from the BA.2. The spontaneously/dynamically increasing and decreasing trends of mutations highlight the loss of mutations in the Recombinants that were associated with the SARS-CoV-2 replication efficiency, infectivity, and disease severity, rendering them functionally with low infectivity and pathogenicity. Linkage disequilibrium (LD) analysis revealed that mutations comprising the LD blocks of BA.1, BA.2, and Recombinants were found as minor alleles or as low-frequency alleles in the LD blocks from the previous SARS-CoV-2 variant samples, especially Pre-VOC. Moreover, a dissipation in the size of LD blocks as well as LD decay along with a high negative regression coefficient (R squared) value was demonstrated in the Omicron and BA.1 and BA.2 lineages, which corroborated with the breakpoint analysis.ConclusionTogether, the findings help to understand the evolution and emergence of Recombinants after the Omicron lineages, for sustenance and adaptability, to maintain the epidemic spread of SARS-CoV-2 in the host population already high in immunity levels.