bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, influencing factors, and prediction model construction of anemia in ankylosing spondylitis based on real-world data: An exploratory study
Authors: Gong Yifan , Yang Kun , Geng Zhaoyang , Liu Hongxiao 
Published: February 2025

Objective
This study aimed to explore the prevalence and influencing factors of anemia in patients with ankylosing spondylitis (AS) using real-world data and to construct a predictive model for anemia in AS.

Methods
In November 2023, we accessed the database from China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN). Clinical data of AS collected from the CERTAIN between March 2022 and September 2023 were analyzed. Demographic information, clinical assessment scales, and laboratory test results of the patients were collected. According to the anemia diagnostic criteria established by the World Health Organization (WHO) in 2018, patients were divided into anemia group and non-anemia group. Statistical analyses were performed using SPSS 25.0 software, including χ2 tests, independent sample t-tests to compare differences between the two groups, and multivariate stepwise logistic regression analysis to explore the influencing factors of anemia in AS. The predictive efficacy of the model was evaluated by plotting receiver operating characteristic (ROC) curves. Calibration was assessed through the Hosmer-Lemeshow goodness-of-fit test, and a calibration curve was plotted to comprehensively evaluate the predictive capability of the model.

Results
A total of 251 patients were included in this study, among which 58 cases had anemia (23.1%). There were significant differences in gender, ossification, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) indicators, and clinical assessment scale results between the two groups (P < 0.05). The results of multivariate stepwise logistic regression analysis showed that female gender, underweight, ossification, abnormal CRP and ESR were independent risk factors for anemia in AS (P < 0.05). Based on the results of multivariate stepwise logistic regression analysis, a predictive model for anemia in AS was established as Logit(P) = −5.02 + 2.041 × gender −1.11 × BMI(body mass index) category + 1.103 × ossification category + 0.942 × CRP category + 1.476 × ESR category. The ROC curve analysis showed that the area under the curve of the model for predicting anemia in AS was 0.857 (95% CI: 0.808 ~ 0.906). The Omnibus test of model coefficients yielded χ2 = 85.265, P < 0.001. The Hosmer-Lemeshow test showed χ2 = 7.005, P = 0.536 (P > 0.05).

Conclusion
Analysis of real-world AS diagnosis and treatment data showed that the prevalence of anemia in Chinese AS was 23.1%. The occurrence of anemia was closely related to female gender, underweight, ossification, and abnormal CRP and ESR. The logistic model constructed based on these indicators for predicting the risk of anemia in AS demonstrated good efficacy.
Long-Term Health-Related Quality of Life in Kawasaki Disease–Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China
Authors: Zhou Yun , Chen Mei , Gao Wenting , Chen Yu , Meng Ying 
Published: February 2025

Abstract

Background:
The impact of coronary artery aneurysms (CAAs) caused by Kawasaki disease (KD) on long-term health-related quality of life (HRQOL) in children has not been well documented.

Methods:
This study investigated long-term HRQOL in a large sample of children diagnosed with KD-related CAAs. A case-control, retrospective study included 66 patients with KD-related CAAs. A total of 98 hospitalized patients were matched as controls based on age and sex: 49 patients were allocated to a group with pneumonia and 49 patients were allocated to a group with arterio-arterial fistula. Both child-reported and parent-proxy–reported Pediatric Quality of Life Inventory surveys were collected.

Results:
The median (IQR) follow-up period was 5.64 (3.81-7.47) years (range, 1.03-10.67 years). The mean (SD) age at diagnosis was 3.73 (1.93) years. At baseline, children and parents as their proxies reported similar HRQOL scores for KD-related CAAs and arterio-arterial fistula that were considerably lower than for pneumonia, respectively. At long-term follow-up, children in the small and medium-sized aneurysms group reported a mean (SD) score of 81.61 (19.50), which was comparable to the arterio-arterial fistula group (83.32 [18.24]), 9.51 points lower than that of the pneumonia group (P = .014), and 9.70 points higher than that of the giant aneurysms group (P = .012). Parents also reported a comparable mean (SD) score of 81.03 (12.57) vs 83.30 (15.17) in the small and medium-sized aneurysms group and arterio-arterial fistula group, both of which had statistically significantly lower scores than the pneumonia group (P = .010) and higher scores than the giant aneurysms group (P = .009).

Conclusion:
Despite improvement in HRQOL scores, children with documented KD-related CAAs without complete recovery often encountered issues that disrupted their well-being during long-term follow-up. Routine outpatient HRQOL screening could be instituted to help eliminate the risk of long-term disability following initial clinical improvement.
To Commit or Not to Commit in Product-Innovation Timing Games
Authors: Sun Chia-Hung 
Published: February 2025

Abstract
This research analyzes a firm’s timing of bringing a new product to the market, based on a product-innovation timing game in which the quality of a new product increases over time. We explore the equilibrium outcomes when both firms can precommit to their timing of market entry (the so-called precommitment game), when they cannot credibly precommit to their timing of market entry (the so-called preemption game), and when only one firm can precommit to its timing of market entry (the so-called mixed precommitment game). Sequential entry is the unique equilibrium outcome in all three games. We finally discuss two extended timing games with endogenous commitment choices. The equilibrium involves a precommitment subgame in the endogenous precommitment game with observable delay, while mixed precommitment subgames appear to be the equilibria in undominated strategies in the endogenous precommitment game with action commitment.
Crystal structure of 5′-hydroxy-6′-methoxy-1′-methyl-2′,3′,8′,8a′-tetrahydro-1′H-spiro[cyclohexane-1,7′-cyclopenta[ij]isoquinoline]-2,5-dien-4-one, C18H19NO3
Authors: Yang Li-Qiong , Wu Jie , Qin Hai-Long , Cai Pan-Feng , Liu Ya-Hua , Li Ji-Xin 
Published: February 2025

Abstract
C18H19NO3, monoclinic, P21 (no. 4), a = 10.0669(6) Å, b = 6.9690(4) Å, c = 11.9051(7) Å, β = 113.011(2)°, V = 768.76(8) Å3, Z = 2, R

gt
(F) = 0.0344, wR

ref
(F
2) = 0.0849, T = 170 K.
A Hippocampal-parietal Network for Reference Frame Coordination
Authors: Zheng (征亦诚) Yicheng , Zhou (周信羽) Xinyu , Moseley Shawn C. , Ragsdale Sydney M. , Alday Leslie J. , Wu (吴畏) Wei , Wilber Aaron A. 
Published: February 2025

Navigating space and forming memories based on spatial experience are crucial for survival, including storing memories in an allocentric (map-like) framework and conversion into egocentric (body-centered) action. The hippocampus and parietal cortex (PC) comprise a network for coordinating these reference frames, though the mechanism remains unclear. We used a task requiring remembering previous spatial locations to make correct future action and observed that hippocampus can encode the allocentric place, while PC encodes upcoming actions and relays this to hippocampus. Transformation from location to action unfolds gradually, with ‘Came From’ signals diminishing and future action representations strengthening. PC sometimes encodes previous spatial locations in a route-based reference frame and conveys this to hippocampus. The signal for the future location appears first in PC, and then in hippocampus, in the form of an egocentric direction of future goal locations, suggesting egocentric encoding recently observed in hippocampus may originate in PC (or another “upstream” structure). Bidirectional signaling suggests a coordinated mechanism for integrating allocentric, route-centered, and egocentric spatial reference frames at the network level during navigation.Significance StatementOur study has broad implications for understanding how the brain coordinates and integrates different spatial reference frames. Our data suggests rats can alternate between multiple neural strategies within the same task. In addition, we find out that similar signals are present in both the hippocampus and the PC but at different times, providing novel insights into the mechanisms underlying spatial navigation and memory. It reveals an intricate system involving an extended brain network that includes the hippocampus, PC, and structures anatomically ‘in-between’. The bidirectional signaling suggests this brain network truly operates as a network and not a unidirectional circuit. These findings suggest a focus on brain networks (and not just single regions) is critical for understanding transformations. These processes are fundamental for spatial cognition and related disorders and even for solving problems that may use similar neural machinery, such as building abstract representations from egocentric views, as occurs with object invariance.
Survival analysis between different treatment strategies of mixed adenoneuroendocrine carcinoma (MANEC): a population-based study
Authors: Li Wenkai , Wang Jing , Lin Jie , Sun Lei , Ouyang Manzhao , Ding Jie , Han Cuifang , Li Binbin , Huang Guo-Liang 
Published: February 2025

Background
Mixed adenoneuroendocrine carcinoma (MANEC) is rare and heterogeneous. Currently, there is no concise treatment standard for MANEC. This study aimed to explore the prognostic impact of different treatment methods in MANEC.

Methods
The surveillance, epidemiology and end results database was utilized to evaluate the outcomes of MANEC using propensity score matching (PSM) , stratified and site-specific survival analysis.

Results
A total of 935 patients diagnosed with MANEC were enrolled in this study. Across most analyses, surgery performance (compared with no surgery) was associated with improved survival outcomes for MANEC patients, except for the site-specific analysis of small intestine, in which no significant association between surgery and patients’ survival was found. Radiotherapy exhibited no significant association with patients’ survival in most cases, and associated with poor prognosis of MANEC in certain specific analyses. Inconsistent effects of chemotherapy on MANEC were observed. Positive impact of chemotherapy on MANEC was indicated in PSM for chemotherapy or radiotherapy. Contradictory effects of chemotherapy were suggested based on the stage of MANEC, with unfavorable outcomes in early-stage and favorable outcomes in advanced-stage. The impact of chemotherapy on survival was influenced by the administration of surgery or radiotherapy. Site-specific analyses indicated that chemotherapy was beneficial to MANEC of the hepatic–biliary–pancreatic system.

Conclusions
The results of this study demonstrate the variable impact of different treatment strategies for MANEC. Surgery was generally associated with improved survival outcomes, while radiotherapy did not show a beneficial effect on MANEC. The effects of chemotherapy on MANEC were inconsistent in specific analyses.
Association of ethylene oxide exposure with sex hormones in the general US population: a cross-sectional study
Authors: Wang Shuai , Zhang Zhiyuan , Sun Jiahao , Chen Haijun , Gu Jiaojiao , Zhang Sihan , Zhao Shuhang , Liu Jinting , Jia Linjiao , Li Wentao 
Published: February 2025

Background
Ethylene oxide (EO) is an environmental chemical widely used in industry and has been related to various conditions such as dyslipidemia and metabolic syndrome. However, it is not clear what effect EO has on sex hormones. This paper aims to investigate the connection between EO exposure and sex hormones.

Methods
EO exposure was assessed by measuring blood levels of hemoglobin adducts of EO (HbEO). Based on the National Health and Nutrition Examination Survey (NHANES) 2013–2016 dataset, we assessed linear and nonlinear associations between HbEO and sex hormone levels using weighted multivariate linear regression analyses and weighted generalized additive modeling approaches. We further calculated the threshold effect using a two-piecewise linear regression model. In addition, we performed subgroup analyses.

Results
In men, HbEO levels showed a U-shaped relationship with total testosterone (TT) and sex hormone binding globulin (SHBG), with inflection points ln(HbEO) (natural logarithmic transformed value of HbEO) of 4.12 and 3.78 pmol/g Hb, respectively. HbEO levels in women showed an inverted U-shaped relationship with TT, with an inflection point ln(HbEO) of 4.54 pmol/g Hb. However, to the right of the inflection point, the relationship between HbEO and TT was not statistically significant (β = −0.09, 95%CI −0.21, 0.03). Female HbEO levels were negatively correlated with estradiol (β = −0.11, 95%CI −0.19, −0.03). In addition, we found a positive correlation between HbEO and SHBG in women with a body mass index (BMI) <25 (β = 0.12, 95%CI 0.04, 0.20, P for interaction = 0.007).

Conclusions
EO exposure leads to altered sex hormone levels in the general US population, and further research is required in the future to validate our findings.
Rett syndrome complicated by diabetes mellitus type 1
Authors: Kuniyoshi Yasutaka , Takahashi Satoru 
Published: February 2025

Summary
Rett syndrome (RS) is an X-linked neurodevelopmental disorder primarily affecting females. RS and diabetes mellitus (DM) type 1 are rare disorders with distinct etiologies. Although some cases of RS complicated by DM type 1 have been reported, the association between these distinct conditions is poorly understood and warrants further studies to elucidate the underlying mechanisms and inform clinical management. We report the case of a 10-year-old girl diagnosed with RS and DM type 1. The patient initially presented at 3 years of age with polydipsia, polyuria and decreased appetite over several weeks. Physical examination showed signs of dehydration, and laboratory evaluation revealed hyperglycemia, elevated HbA1c, glycosuria, ketonuria and low C-peptide levels. Anti-glutamic acid decarboxylase antibodies were positive, confirming autoimmune DM type 1. Fluid resuscitation and insulin therapy were initiated with good glycemic control on continuous subcutaneous insulin infusion. A review of her history revealed normal early developmental milestones, including the onset of stereotypical hand movements at 3 years, communication impairment and seizures at 4 years and a diagnosis of autism spectrum disorder. At 10 years of age, genetic testing revealed a pathogenic MECP2 mutation. Clinical features, including breathing abnormalities, bruxism, abnormal tone and inappropriate laughing, met the diagnostic criteria for RS. This is the reported first case of RS with a confirmed MECP2 mutation complicated by DM type 1. Our case report contributes to the increasing evidence supporting the potential association between RS and DM type 1.

Learning points

There is a possible link between RS and DM type 1.

This is the first case report of RS with a confirmed MECP2 mutation complicated by DM type 1.

In cases where patients with RS develop diabetic ketoacidosis, it may manifest as mild acidosis or normal pH despite the presence of high blood sugar levels and dehydration.
Árabes en Paraguay: génesis, evolución y desafíos actuales en Ciudad del Este
Authors: Martínez Lillo Rosa Isabel 
Published: February 2025

El artículo trata el tema de la migración árabe en Paraguay y se articula a partir de tres puntos principales: génesis, evolución y desafíos actuales. El objetivo principal es dar a conocer esta migración que, desde finales del siglo XIX/principios de XX, viaja desde el medio oriente árabe, Bilad Al-Sham, y se instala en el país iberoamericano, a partir de sus coordenadas temporales (evolución), espaciales (ciudades), hasta desembocar en la situación actual de Ciudad del Este que, vinculada a la brasileña Foz de Iguazú, plantea unos retos específicos. Las hipótesis principales son dos: en primer lugar, señalar que el caso paraguayo, aun compartiendo un origen similar al del resto de los migrantes árabes (o “turcos” en su nomenclatura originaria) en América, su desarrollo es genuino en el ámbito iberoamericano debido preferentemente a la idiosincrasia de Paraguay; en segundo lugar, que el caso concreto de su considerada segunda capital, Ciudad del Este, ha de enfrentarse a unos desafíos particulares a causa de su ubicación fronteriza con la brasileña Foz de Iguazú. En cuanto a la metodología, se trata de una investigación bibliográfica-documental de nivel descriptivo, que sigue las pautas del proyecto ideado por Casa Árabe, denominado La Arabia Americana[1], desde una perspectiva multi e interdisciplinaridad. En este artículo que ahora se presenta se aporta documentación actualizada —con el material teórico bibliográfico consultado (en español, portugués y árabe)— así como resultados derivados del trabajo de campo realizado en el propio país entre 2020/2022 gracias a un proyecto del Plan Propio UMA[2]; dicho trabajo de campo se fundamentó en “Historias de vida”, de carácter cualitativo, donde relato e imagen caminan al unísono

[1] Proyecto comenzado en 2008 bajo la dirección de la Dra. Gema Martín Muñoz, que, desde una mirada multidisciplinar y una labor interdisciplinar, se dedicó a analizar la contribución árabe a las identidades latinoamericanas y a poner de relieve los nexos entre ambas realidades. A este proyecto se vinculó Casa América de Madrid y a partir de entonces se llevaron a cabo actividades conjuntas, encuadradas en una investigación más ambiciosa denominada Amrika, que contó con la participación de académicos, expertos y literatos de reconocido nombre, tanto en la realidad hispana como árabe.
[2] Entre los Miembros Investigadores del Proyecto de Investigación, a partir del que se ejecutó el trabajo de campo —realizado con de encuentros, entrevistas e “historias de vida”—, se contaba con expertos del ámbito del Arabismo (Rosa-Isabel Martínez), Economía (Pedro Staevie), Filología (Indiana Jorrat) y Periodismo (Arturo Javier Encinas); además se basó en los estudios geográficos de Gamal Hamdan, sociológicos de Silvia Montenegro, y antropológicos de Alejandro Grimson. También se disfrutó de una beca de la Fundación Carolina (UNILA 2020) y una Estancia de Investigación en la Universidad de Asunción (diciembre 2021), cedida por la Universidad de Málaga.
ПРИРОДА ГИГРОСКОПИЧНОСТИ ЧАСТИЦ АЭРОЗОЛЬНОЙ ДЫМКИ НАД ПЕКИНОМ
Authors: ПРОНЧЕВ Г.Б. , ЕРМАКОВ А.Н. 
Published: February 2025

Атмосферный аэрозоль оказывает значительное влияние на качество воздуха, климат, а также здоровье людей. Проведенное в работе сравнение данных мониторинга газовых примесей и ионного состава аэрозоля в приземной атмосфере над Антверпеном и Пекином показало, что уровень гигроскопичности частиц плотной дымки над Пекином в зимнее время определяет глубина гетерогенных реакций образования сульфатов и нитратов. Обсуждаются динамика и механизмы этих нефотохимических процессов, а также особенности сопряжения нефотохимических процессов в загрязненной дымкой атмосфере. Их быстрое протекание в частицах в сочетании с поглощением из воздуха водяного пара служит причиной аномально высоких массовых концентраций аэрозоля и их изменчивости в период дымки над Пекином. Полученные в работе данные необходимы в прогнозах возникновения плотных дымок, а также при построении моделей переноса газовых и аэрозольных микропримесей в атмосфере.
Atmospheric aerosols have a significant impact on air quality, climate, and human health. The comparison of gaseous impurity and ionic composition monitoring data in the surface atmosphere over Antwerp and Beijing showed that the hygroscopicity level of dense haze particles over Beijing in winter is determined by the depth of heterogeneous reactions of sulfate and nitrate formation. The paper discusses the dynamics and mechanisms of these non-photochemical processes, as well as the features of their coupling in a haze-polluted atmosphere. Their rapid occurrence in particles in combination with the absorption of water vapor from the air causes abnormally high mass concentrations of aerosol and their variability during the haze period over Beijing. The results are necessary for forecasting the occurrence of dense hazes, as well as for constructing models of transfer of gas and aerosol microimpurities in the atmosphere.
Possible Threats of IgA Vasculitis in Children: One Center Experience
Authors: Lanzbergaitė-Manuilova Eglė , Rusonienė Skirmantė , Jankauskienė Augustina 
Published: February 2025

Introduction: Immunoglobulin A vasculitis (IgAV) is the most common vasculitis in children. Although typically self-limiting, IgAV may result in serious complications. Our objective was to evaluate the incidence, clinical features, laboratory predictors and outcomes of IgA vasculitis with gastrointestinal (GI) and kidney involvement.Methods: Medical records of patients <18 years of age with newly diagnosed IgAV between 2013 and 2021 in a single center were analyzed. Demographic, clinical, laboratory data, and incidence of GI and kidney involvement data were analyzed. As laboratory predictors, neutrophil, lymphocyte, platelets count, mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) were calculated.Results: 240 patients with IgAV were included. GI involvement was in 104 patients (43.3%), whereas kidney involvment in 21 patients (8.8%). Age was the only variable associated with increased odds of kidney involvement (OR 3.5, 95% confidence interval 1.39–8.56, p=0.009). None of the laboratory predictors or other tested variables was associated with kidney involvement in univariable logistic regression. The neutrophil and lymphocyte count, NLR and PLR levels were found to be significantly higher in children with GI involvement. There were no bad outcomes: lethal outcome or chronic kidney disease for the patients with GI and kidney involvement in recent study. During two years of surveillance after IgAV diagnosis, 11 cases (4.6%) had indications for kidney biopsy and were diagnosed with IgAV nephritis.Conclusions: Older children were more likely to have kidney disease. Easy obtained laboratory parameters such as NLP, PLR could help to predict GI involvement in early disease stage, but had no value for predicting kidney involvement.