bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogenic Synthesis and Characterization of Silver Nanoparticles With Cyanobacterium Oscillatoria salina Using Against MDR Pathogenic Bacteria and Their Antiproliferative and Toxicity Study
Authors: Bishoyi Ajit Kumar , Mandhata Chinmayee Priyadarsani , Sahoo Chita Ranjan , Samal Priyanka , Dubey Debasmita , Jali Bigyan Ranjan , Alamri Abdulaziz Mohammed , Khan Mohd Shahnawaz , Padhy Rabindra Nath 
Published: January 2025

ABSTRACTThe biosynthesis of silver nanoparticles (AgNPs) using cyanobacteria has gained significant attention due to its cost‐effective and eco‐friendly advantages in green synthesis. Additionally, biogenic AgNPs show great potential for biological applications, particularly in combating infections caused by drug‐resistant bacteria and fungi. This study synthesized using the cyanobacterium Oscillatoria salina (Os‐AgNPs). The Os‐AgNPs were characterized by a UV‐vis spectral absorption peak at 447 nm, and their functional groups were identified through X‐ray diffraction analysis, revealing a crystal structure with a 2θ value of 38°. Transmission electron microscopy (TEM) analysis showed an average nanoparticle size of 9.81 nm. The Os‐AgNPs demonstrated remarkable antioxidant, antibacterial, and antifungal properties. Their antibacterial activity was tested against multidrug‐resistant (MDR) Gram‐positive bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, as well as Gram‐negative bacteria such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa, all isolated from clinical samples. The inhibition zones for bacterial strains ranged from 15 to 20 mm, as measured by the agar‐well diffusion method. Similarly, the Os‐AgNPs exhibited antifungal activity, with 20–30 mm inhibition zones against pathogenic fungi Trichophyton rubrum and Candida tropicalis. Additionally, the antiproliferative effects of the Os‐AgNPs were evaluated on human cancer cell lines, including HeLa (cervical adenocarcinoma) and MD‐AMB‐231 (breast adenocarcinoma). In vivo toxicity studies were conducted using Swiss mouse models to assess the cytotoxic effects. Overall, the results suggest that Os‐AgNPs, biosynthesized using O. salina, hold promise as potential antimicrobial and anticancer agents for pharmaceutical applications.
Investors' Response to Market Volatility and Financial Sophistication
Authors: Pandey Ichchha , Guillemette Michael A. , Pandey Sabina 
Published: January 2025

ABSTRACTUsing data from the 2021 National Financial Capability Study (NFCS), this study examines how individual investors' financial sophistication influences their response to the stock market in two scenarios: when the market drops by 20% and when the market increases by 20% for a brief period. The findings indicate that, relative to holding stocks, individual investors with higher levels of financial sophistication are more likely to purchase additional stocks and less likely to sell stocks when they experience a market drop for a brief period. Similarly, the study investigated how individuals react when the stock market rises for a short period and discovered that they are less inclined to buy and sell stocks than to hold them. Additionally, the results of this study provide insight into the case of myopic loss aversion (MLA), a supplementary finding of this paper. In addition to finding investors' optimal choice of buying and selling when the market moves, the present study provides supporting findings regarding the number of information sources used and trading frequency, all of which make a strong case for the influence of financial sophistication on MLA. In light of the recent COVID‐19 and the ensuing volatility in the stock market, understanding how financial sophistication influences investors' reactions to the stock market is crucial for researchers, financial professionals, and policymakers.
Heterole‐Fused [20]‐ and [22]Smaragdyrins and Fused‐Heterole‐Bridged [20]‐ and [22]Smaragdyrin Dimers
Authors: Kang Cuiying , Rao Yutao , Xu Ling , Zhou Mingbo , Osuka Atsuhiro , Song Jianxin 
Published: January 2025

AbstractIn order to examine the effects of the fused heterole on the electronic properties of aromatic and antiaromatic smaragdyrins, 2,3‐thiophene‐ and 2,3‐indole‐fused [20]smaragdyrins were synthesized by Suzuki‐Miyaura coupling and subsequent oxidative fusion reaction, and were reduced with NaBH4 to the corresponding [22]smaragdyrins. Fused‐thiophene‐ and fused‐pyrrole‐bridged [20]‐ and [22]smaragdyrin dimers were also synthesized in the similar manner. The installed fused heteroles mitigate the paratropic ring current of the [20]smaragdyrin but exert only minor effects on the diatropic ring current of the [22]smaragdyrin. Similar features are also observed for the fused‐heterole‐bridged [20]‐ and [22]smaragdyrin dimers.
Controlling the J‐ and H‐Aggregates and Supramolecular Polymerization Pathways of Anthanthrene by Tuning the Hydrogen Bonding Sites
Authors: Miao Hongya , Yang Fang , Zhang Youzhi , Li Huijie , He Xiaoming 
Published: January 2025

AbstractExploration of new π‐conjugated building blocks for construction of supramolecular polymers is at the forefront of self‐assembly. Herein, we incorporate a highly planar anthanthrene skeleton into the design of two supramolecular monomers 1 and 2. Their supramolecular polymerization have been comprehensively investigated by spectroscopic studies. Our results reveal that the number and/or position of the amide groups exert pronounced effect on the molecular aggregations and the mechanisms of the supramolecular polymerization. Monomer 1 self‐assembles in a cooperative manner to form 1D nanofibers though face‐to‐face H‐type aggregation. In contrast, 2 adopts J‐aggregation to form supramolecular polymer via isodesmic mechanism.
Recent Progress in Halogen‐Doped Single‐Atom Catalysts for Electrochemical Reactions
Authors: Cai Shichang , Wang Qing , Zhang Naying , Chen Chaoqun , Zhang Hanlu , Feng Yagang , Duan Lei , Cheng Yapeng , Meng Zihan , Li Huaiguang , Wu Jiabin 
Published: January 2025

ABSTRACTSince the concept of single‐atom catalysts (SACs) was first proposed in 2011, related research has grown exponentially, establishing SACs as a highly active research field. Compared to conventional supported nanoparticle catalysts, SACs have attracted significant attention due to their theoretically highest atomic utilization efficiency and tunable active sites. Halogen atoms, with their high electronegativity, possess strong electron‐withdrawing ability, enabling them a powerful regulatory effect on the active sites. Although there are numerous comprehensive and high‐quality reviews on SACs, specialized research on halogen‐doped SACs is relatively scarce. Therefore, this article reviewed recent progress in halogen‐doped SACs, categorizing them by the four halogen atoms: fluorine (F), chlorine (Cl), bromine (Br), and iodine (I). We also discussed the application of halogen‐doped SACs in several key electrochemical reactions commonly relevant to clean energy storage and conversion, including hydrogen evolution reaction (HER), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), and CO2 reduction reaction (CO2RR), and elaborated on the corresponding reaction mechanisms. Finally, this paper presented prospects to promote the development of SACs with tunable catalytic activity.
MicroRNA as a Potential Diagnostic and Prognostic Biomarker in Diffuse Large B‐Cell Lymphoma: A Systematic Review and Meta‐Analysis
Authors: Khanmohammadi Shaghayegh , Masrour Mahdi , Fallahtafti Parisa , Hasani Fatemeh 
Published: January 2025

ABSTRACTBackgroundRecently, microRNAs (miRNAs) have been applied as biomarkers for diffuse large B‐cell lymphoma (DLBCL) patients. Early diagnosis and management of DLBCL can improve patient survival and prognosis.AimsThis systematic review and meta‐analysis aimed to evaluate the diagnostic and prognostic accuracy of miRNA biomarkers in DLBCL patients.MethodsWe used the keywords “diffuse large B‐cell lymphoma” and “microRNA” to search databases for original publications until June 14, 2023. Specificity, sensitivity, and AUC were used to assess diagnostic accuracy, and the prognostic value was assessed using the overall survival (OS) and progression‐free survival (PFS) hazard ratio (HR). A subgroup analysis was performed based on the sample type acquired to investigate the heterogeneity.ResultsThirteen diagnostic and 33 prognostic studies were included from 839 articles. The Reitsma bivariate model estimated a sensitivity of 0.788 (95% CI: 0.733–0.834, p < 0.001), a specificity of 0.727 (95% CI: 0.654–0.790, p < 0.001), and an AUC of 0.824 in. The pooled AUC was 0.7385 (95% CI: 0.6847–0.7923, p < 0.0001). The pooled OS and PFS HRs (> 1) were 2.2847 (95% CI: 1.7248–3.0263, p < 0.0001) and 2.4883 (95% CI: 1.7367–3.5650, p < 0.0001). The pooled OS and PFS HRs (< 1) were 0.4965 (95% CI: 0.3576–0.6894, p < 0.0001) and 2.4883 (95% CI: 1.7367–3.5650, p < 0.0001). MiR‐155 diagnostic values had a sensitivity of 0.710 (p > 0.1) and a specificity of 0.725 (p < 0.05), with an AUC of 0.776. miR‐21 diagnostic values had an AUC of 0.8468 (p < 0.0001) and OS HR of 2.8938.ConclusionMicroRNAs could serve as a powerful diagnostic and prognostic tool in DLBCL.
Social Support and Depression Mediate the Relationship Between Childhood Trauma and Nonsuicidal Self‐Injury
Authors: Yao Jiazheng , Zou Yurong , Luo Qianyi , Luo Yuhan , Chunghon Tse , Shang Herui 
Published: January 2025

ABSTRACTNonsuicidal self‐injury (NSSI), which involves the deliberate destruction of body tissue without suicidal intent, is strongly associated with an increased risk of later suicidal behaviour. Disclosing the risk factors for NSSI is therefore vital to prevent the progression to suicide. While documented evidence links NSSI to childhood trauma, depression, social support, a comprehensive perspective that integrates these factors together is lacking. To bridge this gap, we leveraged a chain‐mediating model in this study, to examine the mediating effect of social support and depression on the relationship between childhood trauma and NSSI. As expected, NSSI behaviours were positively correlated with depression scores (r = 0.492, padj < 0.001), childhood trauma scores (r = 0.306, padj < 0.001), and negatively correlated with the social support scores (r = −0.168, padj = 0.020). Importantly, in the chain‐mediating model, increased childhood trauma was associated with decreased social support (β = −0.532, t = −9.086, p < 0.001), which in turn was linked with increased depressive symptoms (β = −0.193, t = −2.957, p < 0.01), ultimately contributing to greater odds of NSSI behaviours. Our findings elucidated the complex psychological mechanisms underlying the interplay between childhood trauma, social support and depression severity, suggesting that improving social support and intervening early in depression may be potential ways to reduce the risk of NSSI.
A Novel Codebook Based CSI Reconstruction Algorithm in FDD Massive MIMO Systems
Authors: Song Xinyang , Li Gang , Qi Jinping 
Published: January 2025

ABSTRACTChannel state information (CSI) plays a critical role for beamforming technology in frequency division duplex (FDD) massive multiple‐input and multiple‐output (MIMO) systems. In order to improve the beamforming accuracy, we present a novel codebook based CSI reconstruction algorithm to enhance CSI feedback performance, thereby improving communication quality. Based on the existing codebook feedback mechanism, initially, we leverage channel temporal correlation to smooth the precoding matrix using a sliding window approach, where both Type I and Type II codebooks are considered. Subsequently, a minimum mean square error (MMSE) based modification technique is introduced to modify the reconstruction result. The proposed CSI reconstruction method incorporates an adjustable weighting parameter within the sliding window, rendering it adaptable to channels with different user speeds, such as high‐speed train communication channel. Moreover, our algorithm entirely operates at the base station (BS). Therefore, there is no additional feedback overhead compared with traditional codebook based CSI feedback methods. Numerical results present the proposed algorithm outperforms baselines for beamforming.
Seasonal lake‐to‐air temperature transfer functions derived from an analysis of 1395 modern lakes: A tool for reconstructing air temperature from proxy‐derived lake water temperature
Authors: Terrazas Alexa , Hwangbo Nathan , Arnold Alexandrea J. , Ulrich Robert N. , Tripati Aradhna 
Published: January 2025

AbstractLacustrine palaeotemperature reconstructions are important for characterising past temperature and hydroclimate change, validating multi‐proxy reconstructions and evaluating global climate models. In particular, lake water temperature is often derived from geochemical proxies—including clumped isotopes (Δ47), oxygen isotopes (δ18O), alkenone lipids (Uk’37) and GDGT compounds (TEX86). However, global climate models, constrained by resolution, computational demand and cost, are designed to simulate large‐scale processes, often at the expense of resolving lakes and simulating lake temperature. Consequently, this limitation complicates the comparison of climate model‐simulated variables such as air temperature, with lake water temperature or with other proxy variables (e.g. pollen‐derived air temperature), and requires the use of a transfer function to relate lake temperature to air temperature. Previous work developed transfer functions to translate proxy‐derived seasonal lake water temperature to mean annual air temperature using ground‐based measurements from 88 lakes. This study reports new lake‐to‐air temperature transfer functions (for annual, spring through summer, spring, summer and warmest month) that incorporate lake surface water temperature, and new variables including latitude and elevation, by analysing climate reanalysis data and long‐term satellite observations of surface temperatures for 1395 modern lakes via regression‐based inverse modelling. With the use of multiple regression models and a dataset roughly 10 times larger, the error in predictions of mean annual air temperature is reduced by up to 48% compared to previous work. To demonstrate the potential of the new transfer functions for integrating and comparing proxy data with model output, Pliocene and Pleistocene mean annual air temperature was reconstructed from Δ47‐derived lake temperatures and compared with model simulations for the Last Glacial Maximum and mid‐Piacenzian warm period. The new transfer functions, with reduced error, should enable more accurate palaeotemperature reconstructions from proxy‐derived lake water temperature and allow for more comprehensive assessments of climate model skill.
Comprehensive Characterization of Overt Myelofibrosis in an Asian Cohort: Phenotype, Mutation Landscape and Discordance Among Scoring Systems
Authors: Chang Yu‐Sung , Wang Yu‐Hung , Wei Chao‐Hung , Chen Yu‐Wen , Lin Hsing‐Yu , Lin Chien‐Chin , Tsai Xavier Cheng‐Hong , Yuan Chang‐Tsu , Tien Feng‐Ming , Lin Yun‐Chu , Lee Sze‐Hwei , Kuo Yuan‐Yeh , Chuang Ming‐Kai , Ko Bor‐Sheng , Yao Ming , Tien Hwei‐Fang , Chou Wen‐Chien , Hou Hsin‐An 
Published: January 2025

ABSTRACTVarious prognostic scoring systems in myelofibrosis (MF) have been developed to guide clinical decision‐making in MF. However, discrepancies between different scoring systems for individual patients remain poorly understood, which can result in conflicting treatment recommendations. Moreover, data regarding there applicability in Asian populations remain scarce. We conducted a retrospective analysis of patients with overt MF at National Taiwan University Hospital from November 1, 2006, to November 30, 2023. This study evaluates the distribution, concordance, and prognostic value of various scoring systems (IPSS, DIPSS, DIPSS+, MYSEC‐PM, MIPSS70, MIPSS70+v2, GIPSS), focusing on the mutational landscape, particularly TP53 mutations, and cytopenic phenotypes in an Asian MF cohort. All prognostic systems effectively stratified patients by risk (p < 0.005); however, concordance between systems was low (Cohen's κ < 0.4, except for IPSS vs. DIPSS+). GIPSS demonstrated superior performance with a comparable C‐index but lower Akaike and Bayesian information criterion values. Besides high‐molecular risk mutations, TP53 mutations (5.2%) were associated with worse overall survival (OS) (5‐year: 30% vs. 68%, p < 0.001) and a trend toward higher leukemic transformation (5‐year: 22% vs. 10%, p = 0.055). Cytopenic phenotype (59%) was associated with a higher incidence of ASXL1 mutations (44% vs. 28%, p = 0.04). In multivariable analysis, elderly patients, higher‐risk GIPSS, TP53 mutation and cytopenic phenotype were associated with a poorer OS. This study validated multiple prognostic scoring systems in an Asian MF cohort, with GIPSS showing superior risk stratification. Further, cytopenic phenotype and TP53 mutations were identified as independent factors linked to poorer survival.
Remote Food Security Research Project: Applying an Indigenist Research Lens
Authors: Chan Ellie , Deen Caroline , Thompson Kani , Stubbs Emma , Webb Amanda , Baghbanian Abdolvahab , Cadet‐James Yvonne 
Published: January 2025

ABSTRACTThis paper aimed to reflect on how Rigney's model of Indigenist research informed the research design of a project which explored community‐led solutions to improve food security in remote Aboriginal and Torres Strait Islander communities. The project was conducted in partnership with two Aboriginal Community Controlled Health Organisations (ACCHOs); Apunipima Cape York Health Council (Apunipima) and Central Australian Aboriginal Congress (Congress), communities in Central Australia and Cape York, Queensland and researchers from the University of Queensland, Monash University, Dalhousie University and Menzies School of Health Research. On reflection the principles of Indigenist research were evident providing a means of resistance to oppression through Indigenous stakeholders being in control of research to address social determinants, in this case food security. Aboriginal and Torres Strait Islander world views, lived experiences and knowledges were embedded in the research and informed governance, implementation and knowledge translation. ACCHOs and communities gained a political voice through advocacy and actions at the local, state and national levels. The development of a Community Framework led by ACCHOs and community stakeholders to address food security serves to talk to the three principles of ‘Resistance, Political Integrity and Privileging Indigenous Voices’.
Deep Learning for Bond Yield Forecasting: The LSTM‐LagLasso
Authors: Nunes Manuel , Gerding Enrico , McGroarty Frank , Niranjan Mahesan , Sermpinis Georgios 
Published: January 2025

ABSTRACTWe present long short‐term memory (LSTM)‐LagLasso, a novel explainable deep learning approach applied to bond yield forecasting. Our method involves feature selection from a large universe of potential features and forecasts bond yields using dynamic LSTM networks. It examines the internal gating signals of a trained LSTM and explains their dynamics through exogenous variables that may influence bond price formation. By considering these variables at various lags and using the Lasso technique for feature selection, we demonstrate how different hidden units within the LSTM dynamically adjust to make predictions across different temporal regimes and how their evolution is shaped by various external factors. In an empirical study on government bond yield forecasting, we demonstrate the statistical accuracy of LSTM‐LagLasso compared to a multilayer perceptron (MLP) and highlight its explainability.
Mcl‐1 is a Gatekeeper Molecule to Regulate the Crosstalk Between Ferroptotic Agent‐Induced ER Stress and TRAIL‐Induced Apoptosis
Authors: Lee Young‐Sun , Vafaeinik Farzaneh , Mouakkad Lila , Kim Dong‐Hyun , Song Xinxin , Zhang Lin , Lee Yong J. 
Published: January 2025

ABSTRACTWe previously reported that ferroptosis interplays with apoptosis through the integration of two independent pathways: the endoplasmic reticulum (ER) stress signaling pathway and the mitochondria‐dependent apoptotic signaling pathway. In this study, we investigated a potential gatekeeper molecule, Mcl‐1, between the two signal transduction pathways. Morphology studies and cell death analyses confirmed that a combination treatment of ferroptotic agent erastin (ERA) and apoptotic agent TRAIL (tumor necrosis factor‐related apoptosis‐inducing ligand) synergistically enhances TRAIL‐induced apoptosis in human pancreatic adenocarcinoma BxPC3 and human colorectal carcinoma HCT116 cells. We further observed that ERA upregulated the proapoptotic proteins PUMA (p53 upregulated modulator of apoptosis) and NOXA, as well as the anti‐apoptotic protein Mcl‐1 (myeloid cell leukemia sequence 1). These results suggest that ERA upregulates these molecules which results in maintenance of the balance between them. Interestingly, this balance was offset when BxPC3 cells and HCT116 cells were treated with ERA in combination with TRAIL. Our studies suggest that the imbalance between PUMA and NOXA and Mcl‐1 during the combined treatment is responsible for ERA‐enhanced TRAIL‐induced apoptosis. This hypothesis was tested by employing a HCT116 Mcl‐1 knock‐in of phosphorylation site mutant (S121A/E125A/S159A/T163A) and investigated the synergistic interaction between the ERA and TRAIL. Along with morphology and cell death studies, immunoblotting analyses revealed that HCT116 Mcl‐1 knock‐in mutant cells effectively inhibited reduction of Mcl‐1 and apoptosis promoted by the combination treatment. Moreover, ERA enhanced Mcl‐1 inhibitor‐induced apoptosis. Collectively, our studies suggest that Mcl‐1 is a gatekeeper molecule between the ER stress pathway and the mitochondria‐dependent apoptotic pathway.
Breast MRI to Screen Women With Extremely Dense Breasts
Authors: Sitges Carla , Mann Ritse M. 
Published: January 2025

Women with extremely dense breasts are at a higher risk of breast cancer, and the sensitivity of mammography in this group is reduced due to the masking effect of overlapping tissue. This review examines supplemental screening methods to improve detection in this population, with a focus on MRI. Morphologic techniques offer limited benefits, digital breast tomosynthesis (DBT) shows inconsistent results, and ultrasound (US), while improving cancer detection rates (CDR), results in a higher rate of false positives. Functional imaging techniques show better performance, molecular breast imaging increases CDR but is limited in availability, and contrast‐enhanced mammography is promising, with good results and as an accessible technique, but requires further validation. MRI, with sensitivity ranging from 81% to 100%, is the most supported modality. Despite strong evidence for MRI in this population, high costs, use of contrast, and longer scan times hinder widespread use. Abbreviated MRI protocols aim to overcome these barriers by reducing costs and scan duration. As personalized screening becomes a future focus, MRI remains the most effective option for women with extremely dense breasts.Level of Evidence1Technical EfficacyStage 5