bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Immunohistochemistry Based on Ultrasonic Thermal Steam Heating for Improvement of Intraoperative Diagnosis
Authors: Yu Guangyin , Tao Lili , Liao Mengying , Huang ChuQiang , Chen Cuimin , Yin Xiaomin 
Published: December 2023

Objectives:
To evaluate the role of rapid immunohistochemistry (RIHC) based on ultrasonic thermal steam heating in improving diagnostic accuracy of intraoperative frozen section diagnosis and to recommend RIHC antibody panels for pathologic differential diagnosis.

Materials and Methods:
RIHC based on ultrasonic thermal steam heating was tested for intraoperative frozen diagnosis with difficulty in diagnosis, and all slides were reviewed and compared with the final diagnosis. Ninety-three cases of surgical specimens involving RIHC examination were studied. Discordance rates with paraffin immunohistochemistry were calculated.

Results:
In 93 cases where RIHC was performed, 85 cases (91%) were proven to be helpful for the diagnosis. A total of 58 antibodies were used for RIHC 276 times, of which 19 antibodies were not effective 25 times. Fifteen RIHC antibody panels are recommended based on staining stability and utilization frequency.

Conclusion:
After improving the staining method, ultrasonic thermal steam heating RIHC is practical, convenient, and cost-effective, making it suitable for use in any pathology department with routine immunohistochemistry reagents. It plays an important auxiliary role in improving the accuracy of intraoperative rapid pathologic diagnosis.
Clinical Efficacy, Safety, and Complications of the Arthroscopic Cartilage Shaving Procedure for Secondary Osmidrosis Treatment
Authors: Chang Juo-Mei , Hsiao Yen-Chang 
Published: December 2023

Background
Axillary osmidrosis is a common disease with negative psychosocial impact on patients. Further, many treatment modalities are not sufficient and result in recurrence.

Objective
We aimed to evaluate the effectiveness and safety of using a cartilage shaver in patients with recurrent osmidrosis to remove tightly attached apocrine glands and subdermal scars.

Methods
We retrospectively evaluated 24 patients with secondary axillary osmidrosis who underwent cartilage shaving surgery between January 2013 and May 2022. We analyzed the incidence of complications, including seroma, infection, pigmentation, wound dehiscence, skin necrosis, scarring, shoulder movement limitation, comedones/sebaceous cysts, and nerve injury. Clinical effectiveness was also evaluated.

Results
Excellent or good efficacy with improved malodor was achieved in 24 patients (47 axillae [100%]). Complications were observed in 16 (36.17%) axillae, including hematomas (n = 2), pigmentation (n = 7), skin necrosis (n = 3), and comedones/sebaceous cysts (n = 4); one patient (2.13%) required local debridement. Mean Vancouver Scar Scale scores were markedly low (5.41 to 4.67). Scar tissue did not interfere with the shaving surgery, allowing for successful removal of the apocrine glands.

Conclusions
Secondary osmidrosis treatment using a cartilage shaver system yielded satisfactory and better scar results than the patients' previous treatments.
Genetic ancestry-specific Molecular and Survival Differences in Admixed Breast Cancer Patients
Authors: Telonis Aristeidis G. , Rodriguez Daniel A. , Spanheimer Philip M. , Figueroa Maria E. , Goel Neha 
Published: December 2023

Objective:
We aim to determine whether incremental changes in genetic ancestry percentages influence molecular and clinical outcome characteristics of breast cancer in an admixed population.

Summary Background Data:
Breast cancer patients are predominantly characterized as “Black” or “White” based on self-identified race/ethnicity or arbitrary genetic ancestry cutoffs. This limits scientific discovery in populations that are admixed or of mixed race/ethnicity as they cannot be classified based on historical race/ethnicity boxes or genetic ancestry cutoffs.

Methods:
We used the TCGA cohort and focused on genetically admixed patients that had less than 90% European, African, Asian, or Native American ancestry.

Results:
Genetically admixed breast cancer patients exhibited improved 10-year overall survival relative to those with>90% European ancestry. Within the luminal A subtype, patients with lower African ancestry had longer 10-year overall survival compared to those with higher African ancestry. Correlation of genetic ancestry with gene expression and DNA methylation in the admixed cohort revealed novel ancestry-specific intrinsic PAM50 subtype patterns. In luminal A tumors, genetic ancestry was correlated with both the expression and methylation of signaling genes, while in basal-like tumors, genetic ancestry was correlated with stemness genes. In addition, we took a machine-learning approach to estimate genetic ancestry from gene expression or DNA methylation, and were able to accurately calculate ancestry values from a reduced set of 10 genes or 50 methylation sites that were specific for each molecular subtype.

Conclusions:
Our results suggest that incremental changes in genetic ancestry percentages result in ancestry-specific molecular differences even between well-established PAM50 subtypes which may influence disparities in breast cancer survival outcomes. Accounting for incremental changes in ancestry will be important in future research, prognostication, and risk-stratification, particularly in ancestrally diverse populations.
Surveillance Endoscopy in Pediatric Esophageal Atresia: Toward an Evidence-Based Algorithm
Authors: Yasuda Jessica L , Kamran Ali , Servin Rojas Maximiliano , Hayes Cameron , Staffa Steven J , Ngo Peter D , Chang Denis , Hamilton Thomas E , Demehri Farokh , Mohammed Somala , Zendejas Benjamin , Manfredi Michael A 
Published: December 2023

BACKGROUND:
Individuals with esophageal atresia (EA) have lifelong increased risk for mucosal and structural pathology of the esophagus. The use of surveillance endoscopy to detect clinically meaningful pathology has been underexplored in pediatric EA. We hypothesized that surveillance endoscopy in pediatric EA has high clinical yield, even in the absence of symptoms.

STUDY DESIGN:
The medical records of all patients with EA who underwent at least 1 surveillance endoscopy between March 2004 and March 2023 at an international EA referral center were retrospectively reviewed. The primary outcomes were endoscopic identification of pathology leading to an escalation in medical, endoscopic, or surgical management. Logistic regression analysis examined predictors of actionable findings. Nelson-Aalen analysis estimated optimal endoscopic surveillance intervals.

RESULTS:
Five hundred forty-six children with EA underwent 1,473 surveillance endoscopies spanning 3,687 person-years of follow-up time. A total of 770 endoscopies (52.2%) in 394 unique patients (72.2%) had actionable pathology. Esophagitis leading to escalation of therapy was the most frequently encountered finding (484 endoscopies, 32.9%), with most esophagitis attributed to acid reflux. Barrett’s esophagus (intestinal metaplasia) was identified in 7 unique patients (1.3%) at a median age of 11.3 years. No dysplastic lesions were identified. Actionable findings leading to surgical intervention were found in 55 children (30 refractory reflux and 25 tracheoesophageal fistulas). Significant predictors of actionable pathology included increasing age, long gap atresia, and hiatal hernia. Symptoms were not predictive of actionable findings, except dysphagia, which was associated with stricture. Nelson-Aalen analysis predicted occurrence of an actionable finding every 5 years.

CONCLUSIONS:
Surveillance endoscopy uncovers high rates of actionable pathology even in asymptomatic children with EA. Based on the findings of the current study, a pediatric EA surveillance endoscopy algorithm is proposed.
Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants
Authors: Lopez Paola A. , Nziza Nadège , Chen Tina , Shook Lydia L. , Burns Madeleine D. , Demidkin Stepan , Jasset Olyvia , Akinwunmi Babatunde , Yonker Lael M. , Gray Kathryn J. , Elovitz Michal A. , Lauffenburger Douglas A. , Julg Boris D. , Edlow Andrea G. 
Published: December 2023

SUMMARYCompletion of a COVID-19 vaccination series during pregnancy effectively reduces COVID-19 hospitalization among infants less than 6 months of age. Elucidating the dynamics of transplacental transfer of maternal vaccine-induced antibodies, and their persistence in infants at 2, 6, 9 and 12 months, has implications for new vaccine development and timing of vaccine administration in pregnancy to optimize protection of the mother-infant dyad. We evaluated anti-COVID antibody IgG subclass, Fc-receptor binding profile, and activity against wild-type Spike and RBD, and five variants of concern (VOCs) in 153 serum samples from 100 unique infants. Maternal IgG1 and IgG3 responses persisted in 2- and 6-month infants to a greater extent than the other IgG subclasses, with highest persistence of antibodies that bind placental neonatal Fc-receptor as well as FcψR3A. Timing of maternal vaccination and fetal sex were drivers of antibody persistence in infants. Lowest persistence at 2 and 6 months was observed against the Omicron RBD-specific region. Maternal vaccine timing, placental Fc-receptor binding capabilities, antibody subclass, fetal sex, and VOC all impact the persistence of maternal vaccine-induced antibodies in infants up to 12 months.
Autonomous and policy-induced behavior change during the COVID-19 pandemic: Towards understanding and modeling the interplay of behavioral adaptation
Authors: Zozmann Heinrich , Schüler Lennart , Fu Xiaoming , Gawel Erik 
Published: December 2023

AbstractChanges in human behaviors, such as reductions of physical contacts and the adoption of preventive measures, impact the transmission of infectious diseases considerably. Behavioral adaptations may be the result of individuals aiming to protect themselves or mere responses to public containment measures, or a combination of both. What drives autonomous and policy-induced adaptation, how they are related and change over time is insufficiently understood. Here, we develop a framework for more precise analysis of behavioral adaptation, focusing on confluence, interactions and time variance of autonomous and policy-induced adaptation. We carry out an empirical analysis of Germany during the fall of 2020 and beyond. Subsequently, we discuss how behavioral adaptation processes can be better represented in behavioral-epidemiological models. We find that our framework is useful to understand the interplay of autonomous and policy-induced adaptation as a “moving target”. Our empirical analysis suggests that mobility patterns in Germany changed significantly due to both autonomous and policy-induced adaption, with potentially weaker effects over time due to decreasing risk signals, diminishing risk perceptions and an erosion of trust in the government. We find that while a number of simulation and prediction models have made great efforts to represent behavioral adaptation, the interplay of autonomous and policy-induced adaption needs to be better understood to construct convincing counterfactual scenarios for policy analysis. The insights presented here are of interest to modelers and policy makers aiming to understand and account for behaviors during a pandemic response more accurately.
Seasonal fluctuations in the bone microstructure ofSciurus vulgaris fuscoaterhumeri: a case study using phenomics on µCT-scans
Authors: van Heteren AH , Luft AS , Toth M , Dewanckele J , Marsh M , De Beenhouwer J 
Published: December 2023

AbstractSciurus vulgarisLinnaeus, 1758, the red squirrel, is a small, mostly arboreally living rodent, spread across the Palearctic. It is mostly vegetarian, feeding on plants, fungi and seeds, and is less active in the winter months, but does not hibernate. In this lateral study, the humeri of the subspeciesSciurus vulgaris fuscoater, the Central European red squirrel, were analysed to uncover potential intraspecific variation between individuals found in different seasons.The µCT-scans were obtained with a resolution of 26 microns. Five bone parameters were calculated and statistically evaluated with regards to seasonal variations: total volume, bone volume, endocortical surface, cortical thickness, and average trabecular thickness.Bone volume, trabecular thickness and endocortical thickness correlate with bone size, whereas cortical thickness does not. Seasonal differences were observed between the warmer summer and autumn months versus the colder winter and spring months for all parameters. We, speculatively, relate the observed seasonal variation to nutrient intake, notably calcium. These results offer a deeper understanding of intraindividual variation in red squirrels, that may be useful in further ecological, taxonomic, and paleontological research.
Bioaugmentation strategies based on bacterial and methanogenic cultures to relieve stress in anaerobic digestion of protein-rich substrates
Authors: Agostini Sara , Bucci Luca , Doni Davide , Costantini Paola , Gupte Ameya , Müller Bettina , Sibilla Fabrizio , Basaglia Marina , Casella Sergio , Kougias Panagiotis G. , Campanaro Stefano , Favaro Lorenzo , Treu Laura 
Published: December 2023

AbstractAnaerobic co-digestion of protein-rich substrates is a prominent strategy for converting valuable feedstocks into methane, but it releases ammonia, which can inhibit methanogenesis. This study developed a cutting-edge combined culturomic and metagenomic approach to investigate the microbial composition of an ammonia-tolerant biogas plant. Newly-isolated microorganisms were used for bioaugmentation of stressed batch reactors fed with casein, maize silage and their combination. A co-culture enriched with proteolytic bacteria was isolated, selected and compared with the proteolytic collection strainPseudomonas lundensisDSM6252. The co-culture andP. lundensiswere combined with the ammonia-resistant archaeonMethanoculleus bourgensisMS2 to boost process stability. A microbial population pre-adapted to casein was also tested for evaluating the digestion of protein-rich feedstock. The promising results suggest combining proteolytic bacteria andM. bourgensiscould exploit microbial co-cultures to improve anaerobic digestion stability and ensure stable productivity even under the harshest of ammonia conditions.Graphical abstractHighlights-High ammonia release from protein-rich substrates inhibits anaerobic digestion-Newly isolated bacterial strains from anaerobic digester were obtained-Proper bioaugmentation alleviates stress in casein and maize silage co-digestion-Bioaugmentation with a hydrolytic/hydrogenotrophic co-culture enhances CH4yields
An improved dynamic model identification method for small unmanned helicopter
Authors: Zhou Jian , Liu Shuyu , Lu Jian , Liu Xinyu 
Published: December 2023

Purpose
The purpose of this paper is to introduce an improved system identification method for small unmanned helicopters combining adaptive ant colony optimization algorithm and Levy’s method and to solve the problem of low model prediction accuracy caused by low-frequency domain curve fitting in the small unmanned helicopter frequency domain parameter identification method.

Design/methodology/approach
This method uses the Levy method to obtain the initial parameters of the fitting model, uses the global optimization characteristics of the adaptive ant colony algorithm and the advantages of avoiding the “premature” phenomenon to optimize the initial parameters and finally obtains a small unmanned helicopter through computational optimization Kinetic models under lateral channel and longitudinal channel.

Findings
The algorithm is verified by flight test data. The verification results show that the established dynamic model has high identification accuracy and can accurately reflect the dynamic characteristics of small unmanned helicopter flight.

Originality/value
This paper presents a novel and improved frequency domain identification method for small unmanned helicopters. Compared with the conventional method, this method improves the identification accuracy and reduces the identification error.
Wastewater treatment plant site selection using GIS and multicriteria decision analysis
Authors: Awawdeh Muheeb , Al-Rousan Zaid , Alkaraki Khaled 
Published: December 2023

PurposeCesspits are the means for each house to dispose of wastewater in the Bani Kinanah District (BKD) of Jordan, which creates severe environmental complications. This research aimed to find a suitable site for a wastewater treatment plant (WWTP) in BKD.Design/methodology/approachGeographic Information System (GIS)-based multicriteria decision analysis (MCDA) was used for an optimal site selection for a sewage treatment plant. Several datasets were obtained to prepare the maps of the criteria influencing the choice of the most suitable site for the WWTP. The analytic hierarchy process was used to apply the weights for each factor.FindingsFive classes of suitability were generated: 0.23% very high suitability, 8.49% high suitability, 47.12% moderate suitability, 37.67% low suitability and 6.49% very low suitability. According to Analytical Hierarchy Process (AHP) results, the elevations, slope and groundwater depth have high importance; where their weights 21%, 19% and 17%, respectively. The most suitable site for establishing a WWTP was found in the northern part of the study area, where it is characterized by relatively low elevations (−90 to −93 m), low slope (0–2.5 %), distance from groundwater level (47–82 m) and the space is sufficient for building the plant (25328 m2, 8861 m2 and 8586 m2).Research limitations/implicationsThis research is limited by the availability of data.Practical implicationsThe research is invaluable for decision makers involved in urban planning.Social implicationsWastewater treatment plants are essential for communities with limited resources such as Jordan. It has also profound impacts on the surrounding environment.Originality/valueFrom the present study, it can be concluded that GIS is essential in urban utility establishment, like urban domestic wastewater treatment site selection. Although the study area has adequate potential areas for establishing WWTP, further assessment of flood vulnerability, wastewater amount quantification, population growth and urban expansion must be seriously considered before implementation.
The political economy explanation of the logic of China’s “two miracles”
Authors: Ren Baoping 
Published: December 2023

Purpose During the Communist Party of China's endeavors over the past century, China has created “two miracles,” namely, large-scale and rapid economic development and long-term social stability.Design/methodology/approach The causes for China's achieving the “two miracles” lie in the adherence to the Party's leadership as the political guarantee, the scientific theoretical guidance as the ideological guarantee, the socialist system as well as the national governance system as the institutional guarantee and giving full play of people's creativity under the Party's leadership as the driving force guarantee.FindingsFrom a political economy point of view, the theoretical logic behind the creation of the “two miracles” is that the combination of the state capacity and the scaling up of markets under the Party's leadership contributes to the rapid economic development and further the long-term social stability based on the financial foundation laid by rapid economic development. The historical experience of the “Two Miracles” can be summed up as the cultivation of state capacity under the leadership of the Party, the synergy and complementarity between the central government and local governments, the combination of development planning and market mechanisms, and the coordination of selective, functional and inclusive industrial policies.Originality/valueIt is necessary to judge future development trends from a medium and long-term development perspective, further promote the co-evolution of the state and the market, reshape the growth regime for high-quality development, fully tap the potential of domestic demand and create a “people-centered” economic development model so as to continue the “two miracles” and achieve a miracle of high-quality development in the second century.
Does empowering leadership enhance employee agility? A serial mediation model
Authors: Naim Mohammad Faraz , Sahai Shikha , Elembilassery Varun 
Published: December 2023

PurposeOrganizational success in a dynamic environment demands leadership and agility. The extant literature on employee agility needs more empirical evidence and appropriate theoretical explanations. This study aims to contribute to the literature by bringing empirical evidence to understand the intervening mechanisms through which empowering leadership influences employee agility and to suggest alternate theoretical explanations.Design/methodology/approachThe mediating role of knowledge-sharing behavior and psychological safety is examined using quantitative data from a sample of 924 employees working in India's information technology industry.FindingsFindings reveal that empowering leadership contributes to psychological safety at the workplace, promoting employees' knowledge-sharing behavior and leading to employee agility. The findings are globally relevant and theoretically consistent.Research limitations/implicationsThe phenomenon is explained in two ways. Firstly, by combining the structural empowerment and motivation perspectives, and secondly, by combining the conservation of resources and social exchange perspectives.Practical implicationsThe findings imply that psychological safety and knowledge-sharing behavior can be used as leading indicators to prepare the organization for success in a dynamic and volatile environment.Originality/valueThis study is one of the earliest attempts to explain the mediating mechanism between empowering leadership and employee agility using serial multiple mediations. Further, this study combines different theoretical perspectives to present the findings more logically.
Green manufacturing practices and SMEs’ sustainable performance: a moderated mediation mechanisms of green innovation and managerial discretion
Authors: Omar Adel , Al-shari Alaa , Shah Syed Haider Ali , Erkol Bayram Gül , Zameer Rahman Eman , Valeri Marco 
Published: December 2023

Purpose
Drawing on the resource-based view, ecological modernization theory and upper-echelon theory, this study aims to explore how green manufacturing practices (GMGP) affect the sustainable performance of small and medium enterprises (SMEs).

Design/methodology/approach
It also examines the mediating role of green innovation (GIN) and the moderating role of managerial discretion (MD). To test the hypothesized model, the data was collected from 394 manufacturing SMEs though survey and analyzed using SPSS and AMOS (SEM).

Findings
The results provide evidence for the positive relationship between GMGP and corporate sustainable performance (CSPR), mediated by GIN. Furthermore, the presence of MD enhances the positive effect of GMGP on CSPR through GIN. Thus, this study enhances the understanding of the relationship between GMGP and CSPR, including its underlying mechanism and conditional effects.

Research limitations/implications
This study collected sample from SMEs located in Punjab province of Pakistan which represents majority of the SMEs; however, future research can take data from other province and with large sample size.

Practical implications
The findings highlight the significance of GMGP and GIN in the manufacturing sector for attaining CSPR goals. GMGP guides business leaders to be more inclined toward the energy and resource consumption as well as waste generation within their organizations which lead to improved CSPR outcomes.

Originality/value
The findings of this study make significant contributions to the existing literature, shedding light on the dynamics between GMGP and CSPR. Moreover, the study offers managerial implications for organizations aiming to enhance their sustainable performance by implementing effective GMGP.