bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular and molecular functions of SETD2 in the central nervous system
Authors: Mitchell Benjamin , Thor Stefan , Piper Michael 
Published: November 2023

ABSTRACT
The covalent modification of histones is critical for many biological functions in mammals, including gene regulation and chromatin structure. Posttranslational histone modifications are added and removed by specialised ‘writer’ and ‘eraser’ enzymes, respectively. One such writer protein implicated in a wide range of cellular processes is SET domain-containing 2 (SETD2), a histone methyltransferase that catalyses the trimethylation of lysine 36 on histone H3 (H3K36me3). Recently, SETD2 has also been found to modify proteins other than histones, including actin and tubulin. The emerging roles of SETD2 in the development and function of the mammalian central nervous system (CNS) are of particular interest as several SETD2 variants have been implicated in neurodevelopmental disorders, such as autism spectrum disorder and the overgrowth disorder Luscan–Lumish syndrome. Here, we summarise the numerous roles of SETD2 in mammalian cellular functions and development, with a focus on the CNS. We also provide an overview of the consequences of SETD2 variants in human disease and discuss future directions for understanding essential cellular functions of SETD2.
The allometry of mitochondrial efficiency is tissue dependent: a comparison between skeletal and cardiac muscles of birds
Authors: Barbe Jessica , Watson Julia , Roussel Damien , Voituron Yann 
Published: November 2023

ABSTRACT
Body mass is known to be a fundamental driver of many biological traits, including metabolism. However, the effect of body mass on mitochondrial energy transduction is still poorly understood and has mainly been described in mammals. Using 13 species of birds ranging from 15 g (finches) to 160 kg (ostrich), we report here that the mitochondrial production of ATP, and the corresponding oxygen consumption, are negatively dependent on body mass in skeletal muscles but not in the heart. Results also showed that mitochondrial efficiency was positively correlated with body mass at sub-maximal phosphorylating states in the skeletal muscle, but not in the heart. This difference between muscle tissues is potentially linked to the difference in energetic demand expandability and the heavy involvement of skeletal muscle in thermoregulation.
When the tap runs dry: the physiological effects of acute experimental dehydration in Peromyscus eremicus
Authors: Blumstein Danielle M. , MacManes Matthew D. 
Published: November 2023

ABSTRACT
Desert organisms have evolved physiological, biochemical and genomic mechanisms to survive the extreme aridity of desert environments. Studying desert-adapted species provides a unique opportunity to investigate the survival strategies employed by organisms in some of the harshest habitats on Earth. Two of the primary challenges faced in desert environments are maintaining water balance and thermoregulation. We collected data in a simulated desert environment and a captive colony of cactus mice (Peromyscus eremicus) and used lab-based experiments with real time physiological measurements; energy expenditure, water loss rate and respiratory exchange rate, to characterize the response to water deprivation. Mice without access to water had significantly lower energy expenditures and in turn, reduced water loss compared to mice with access to water after the first 24 h of the experiment. Additionally, we observed significant mass loss that is probably due to dehydration-associated anorexia a response to limit fluid loss by reducing waste and the solute load as well as allowing water reabsorption from the kidneys and gastrointestinal tract. Finally, we observed body temperature correlated with sex, with males without access to water maintaining body temperature when compared with hydrated males, whereas body temperature decreased for females without access to water, suggesting daily metabolic depression in females.
Long-term stress induced cortisol downregulation, growth reduction and cardiac remodeling in Atlantic salmon
Authors: Opinion April Grace R. , Vanhomwegen Marine , De Boeck Gudrun , Aerts Johan 
Published: November 2023

ABSTRACT
Stress and elevated plasma cortisol in salmonids have been linked with pathological remodeling of the heart and deterioration of fitness and welfare. However, these associations were based on biomarkers that fail to provide a retrospective view of stress. This study is the first whereby the association of long-term stress, using scale cortisol as a chronic stress biomarker, with cardiac morphology and growth performance of wild Atlantic salmon (Salmo salar) is made. Growth, heart morphology, plasma and scale cortisol levels, and expression of genes involved in cortisol regulation of the hypothalamic-pituitary–interrenal axis of undisturbed fish (control) were compared with those of fish exposed daily to stress for 8 weeks. Though scale cortisol levels showed a time-dependent accumulation in both groups, plasma and scale cortisol levels of stress group fish were 29.1% and 25.0% lower than those of control fish, respectively. These results correlated with the overall upregulation of stress-axis genes involved in the systemic negative feedback of cortisol, and local feedback via 11β-hydroxysteroid dehydrogenases, glucocorticoid and mineralocorticoid receptors in the stress treatment at the hypothalamus and pituitary level. These lower cortisol levels were, however, counterintuitive in terms of the growth performance as stress group fish grew 33.7% slower than control fish, which probably influenced the 8.4% increase in relative ventricle mass in the stress group. Though compact myocardium area between the treatments was comparable, these parameters showed significant linear correlations with scale cortisol levels, indicating the involvement of chronic stress in cardiac remodeling. These findings underscore the importance of scale cortisol as biomarker when associating chronic stress with long-term processes including cardiac remodeling.
Fair and Efficient Online Allocations
Authors: Benadè Gerdus , Kazachkov Aleksandr M. , Procaccia Ariel D. , Psomas Alexandros , Zeng David 
Published: November 2023

Trade-Offs in Dynamic Allocation Problems Food rescue organizations often receive donations to allocate to food pantries or families. Donations are unpredictable, and goods are often perishable; as a result, allocations have to be made within a short time frame after arrival without knowledge of future arrivals. It is important that donations go to organizations that are able to use them; at the same time, organizations that serve different communities should be treated equitably. In “Fair and Efficient Online Allocations,” Benadè, Kazachkov, Procaccia, Psomas, and Zeng study fairness-efficiency trade-offs in such online allocation problems. Against adversarial arrivals, no algorithm can provide nontrivial guarantees for both these objectives simultaneously. When item values are drawn from (potentially correlated) distributions, there is no trade-off, and a simultaneously fair and efficient algorithm is presented.
Fiber laser cascaded with an MZ interferometer for simultaneous measurement of temperature and refractive index
Authors: Li Jingwen , Hong Tianjia , Yu Desheng , Che Kaijun , Chen Lujian 
Published: November 2023

A fiber laser with strong spontaneous emission and high signal-to-noise ratio is proposed and experimentally demonstrated for simultaneous measurement of temperature and refractive index (RI). By cascading a single MZ interferometer, the power and the emission spectrum of the fiber laser are modulated by surrounding temperature and RI. The dual parameters are determined from the measured power change and interference dip shift. A temperature sensitivity of 0.146 dB/°C (−0.06nm/∘C) in the range from 20°C to 90°C at an RI of 1.3910 and an RI sensitivity of −156.07dB/RIU (153.70 nm/RIU) in the range from 1.3333 to 1.3910 at 20°C are achieved.
Hybrid multi-channel electrically tunable bandstop filter based on DAST electro-optical material
Authors: Qi Yunping , Zhang Shu , Shi Qiang , Su Mingrui , Zhao Shiyu , Zhou Zihao , Wang Xiangxian 
Published: November 2023

A voltage tunable hybrid multi-channel bandstop filter based on a metal–insulator–metal (MIM) waveguide is presented in this work, which can realize three narrowband and one broadband filtering functions simultaneously. The filter comprises two asymmetric composite cavities, which are filled with organic electro-optical material of 4-dimethylamino-N-methyl-4-toluenesulfonate (DAST). The composite cavity is composed of a rectangular cavity and an annular cavity, and the annular cavity is formed by two rectangular cavities connected with two semi-elliptical annular cavities. The transmission spectrum and magnetic field distribution of the filter are studied and analyzed by the finite element method (FEM), and the effects of the structure parameters on the transmission spectrum are discussed. Our analysis indicates that the bandstop filter has minimum transmittances of 0.02%, 0.29%, and 0.1%, minimum bandwidths of 5 nm, 9 nm, and 25 nm, and maximum quality factors (Q) of 123.7, 87.1, and 44.2, respectively, in three narrowband modes. The stopband bandwidth at the broadband mode is 70 nm, and the adjustable range is 1695–2065 nm. Additionally, the filter characteristics can be adjusted by imposing a control voltage, providing a high degree of tunability and maintaining stable filter performance. Finally, the basic structure is optimized yielding an increased bandwidth of 238 nm for the broadband mode, which does retain great electrical tuning characteristics. Consequently, the proposed structure can be applied with huge potential in high-density integrated circuits and nano-optics.
Circulating antibody-secreting cells are a biomarker for early diagnosis in patients with Lyme disease
Authors: Haddad Natalie S. , Nozick Sophia , Ohanian Shant , Smith Robert , Elias Susan , Auwaerter Paul G. , Lee F. Eun-Hyung , Daiss John L. 
Published: November 2023

Background
Diagnostic immunoassays for Lyme disease have several limitations including: 1) not all patients seroconvert; 2) seroconversion occurs later than symptom onset; and 3) serum antibody levels remain elevated long after resolution of the infection.

Introduction
MENSA (Medium Enriched for Newly Synthesized Antibodies) is a novel diagnostic fluid that contains antibodies produced in vitro by circulating antibody-secreting cells (ASC). It enables measurement of the active humoral immune response.

Methods
In this observational, case-control study, we developed the MicroB-plex Anti-C6/Anti-pepC10 Immunoassay to measure antibodies specific for the Borrelia burgdorferi peptide antigens C6 and pepC10 and validated it using a CDC serum sample collection. Then we examined serum and MENSA samples from 36 uninfected Control subjects and 12 Newly Diagnosed Lyme Disease Patients.

Results
Among the CDC samples, antibodies against C6 and/or pepC10 were detected in all seropositive Lyme patients (8/8), but not in sera from seronegative patients or healthy controls (0/24). Serum antibodies against C6 and pepC10 were detected in one of 36 uninfected control subjects (1/36); none were detected in the corresponding MENSA samples (0/36). In samples from newly diagnosed patients, serum antibodies identified 8/12 patients; MENSA antibodies also detected 8/12 patients. The two measures agreed on six positive individuals and differed on four others. In combination, the serum and MENSA tests identified 10/12 early Lyme patients. Typically, serum antibodies persisted 80 days or longer while MENSA antibodies declined to baseline within 40 days of successful treatment.

Discussion
MENSA-based immunoassays present a promising complement to serum immunoassays for diagnosis and tracking therapeutic success in Lyme infections.
Marginal Artery of Drummond Masquerading as a Fistulous Tract Resulting in Recurrent Lower Gastrointestinal Bleeding
Authors: Bejcek Alexis , Ancha Anupama , Amundsen Tyson , Rodich Sean , Smith Steven , Johnson Christopher 
Published: November 2023

ABSTRACT
Lower gastrointestinal bleeding (LGIB) can be caused by a variety of causes. Pseudoaneurysms have been described as a rare etiology of LGIB and are associated with pancreatic pseudocysts that involve adjacent vasculature. Our study describes a 38-year-old man with recent severe coronavirus disease 2019 and necrotizing pancreatitis presenting with hematochezia and blood clots by gastrostomy-jejunostomy. Initial flexible sigmoidoscopy did not elicit an etiology for the LGIB. Recurrent hematochezia prompted colonoscopy and angiography, which demonstrated a pseudoaneurysm in the marginal artery of Drummond as the source. Our case highlights the importance of repeat evaluation of gastrointestinal bleeding of unknown etiology.
Social logistics: Rethinking public transport as a regional distributor of goods in rural areas. Chances for the long-term establishment of a sustainable regional logistics approach
Authors: Greischel Eva , Nagy Emilia , Conrad Alexander , Schäfer Martina 
Published: November 2023

This paper presents initial findings on the establishment of a social logistics project in a peripheral rural region in Germany. As part of a real-life laboratory, two services were developed and tested with the aim of improving rural supply: the delivery of regional goods and the return of online orders in cooperation with a regional public transport provider, regional retailers and parcel services. An evaluation team provided support to the project in identifying, monitoring, and documenting the societal impact of the services and promoted impact-oriented project management. The concept of providing services of general interest through social logistics and testing them in a real-world laboratory was based on preliminary work in the region. The results indicate that this approach can promote this type of social logistics in the long term. A social logistics approach does not focus solely on economic aspects but emphasises social and environmental benefits for the region. A real-world laboratory approach enables an environment that promotes open exchange, involvement of different stakeholders and joint problem solving in a reflective, iterative process. This methodological approach enabled the continuation and out-scaling of the service’s core offerings immediately after ending the test phase and is seen as an important prerequisite for establishing a long-term perspective.
An Interactive Biography of the Survivor or a Survivor’s Hologram? Novel Methods of Collecting Holocaust Oral Testimony and Their Determinants
Authors: Papier Sylwia 
Published: November 2023

Abstract
This article aims to discuss the Dimensions in Testimony project, designed and launched by the USC Shoah Foundation to establish a novel approach to collecting oral testimony. The Foundation’s project was initially presented to a wide audience, especially by the U.S. press and researchers, as involving the creation of witness holograms. Unfortunately, this is not the case. Misdescribed by media outlets as based around holograms, this USC Shoah Foundation initiative looks, at least for the moment, to create two-dimensional images based on a long recording process and hours of in-depth interviews. Nevertheless, the project is bound to shape the future of Holocaust testimony and oral history itself. The key challenge for its authors remains to explain what the project actually is and to develop the concept of interactive biography, a name proposed by Stephen Smith, but not fleshed out enough in any academic articles in the author’s opinion. Consequently, this paper aims to discuss the USC Shoah Dimensions in Testimony project as a collection of interactive biographies, with particular emphasis on what an interactive biography is, as well as formulate a definition and propose alternative terms. For this purpose, the author proposes an interdisciplinary approach. To define interactive biography, this article will necessarily describe the mechanisms governing the project, the technique for displaying two-dimensional recordings of survivors, and how this aforementioned interactivity operates in the encounter of two-dimensional images of survivors and the recipients of their testimony. Finally, this paper will also look to answer attendant questions, including whether the project works as a post-memory tool for sharing survivor stories, and how are the survivors expressed in a digital tool.
Endogenous money, soft budget constraint and the banking regulation
Authors: Ábel István , Mérő Katalin 
Published: November 2023

AbstractA key observation of the endogenous money theory is that banks create deposits (money) by lending. This means that banks apparently face soft budget constraint in responding to demand for credit. However, there are several limiting factors, which can make the banks' money creation somewhat constrained, and can thus harden their budget constraint. Such factors include the need to preserve banks' profitability and the bank regulations (the capital and liquidity requirements). Previous literature on soft budget constraint (SBC) in banking mentioned government bailouts, central banks lender-of-last-resort policies, or the poorly informed depositors who over-finance banks, as reasons for the SBC for banks. Taking the endogenous money theory as a starting point, we use a different approach. We analyze whether the tools that aimed to keep the bank's budget constrain hard are appropriate for this purpose. Our analysis, as well as lessons from several recent bank crisis episodes suggest, that under current banking regulation SBC is an inherent feature of banking.
Emotional processing deficits in individuals with problematic pornography use: Unpleasant bias and pleasant blunting
Authors: Wang Jianfeng , Li Hong 
Published: November 2023

AbstractBackground and aimsA growing body of evidence indicates a connection between emotional processes and the emergence and progression of addiction. However, scant research has examined the involvement of emotional processing within the framework of problematic pornography use (PPU). This study aimed to examine the electrophysiological and subjective differences in emotional processing between male individuals with PPU and healthy controls (HCs) following exposure to everyday affective images.MethodsEvent-related potentials (ERPs) were recorded from 42 PPU participants (mean age = 20.14 years, SD = 1.35) and 45 HCs (mean age = 20.04 years, SD = 1.45) during an oddball task, in which unpleasant, pleasant, and neutral images were presented as deviant stimuli, while a neutral kettle image served as the standard stimulus. The Self-Assessment Manikin (SAM) was employed to assess participants' subjective experience on the dimensions of valence and arousal.ResultsRegarding subjective measures of emotion, individuals with PPU reported lower valence ratings for unpleasant images compared to HCs. In terms of electrophysiological measures of emotion, PPU participants reported larger P2 amplitudes for unpleasant pictures compared to both pleasant and neutral pictures. Moreover, HCs showed enhanced P3 amplitudes in response to pleasant images compared to neutral images, whereas this effect was not observed in PPU participants.Discussion and ConclusionThese findings indicate that individuals with PPU may display deficits in emotional processing characterized by enhanced responsiveness to negative stimuli and attenuated responsiveness to positive stimuli. The heightened sensitivity to negative stimuli may contribute to the inclination of individuals with PPU to engage in pornography as a coping mechanism for stress regulation. Conversely, their diminished sensitivity to positive stimuli presents a challenge in seeking alternative natural rewards to counter potentially addictive behaviors.
Escucha la voz de Dios
Authors: . Anónimo 
Published: November 2023

Quiero que descubras tus ganas inmensas de volver a VIVIR, dejar el pasado atrás, hacer de lado los problemas, inconvenientes, discusiones, en ocasiones sin fundamento alguno; reproches, peleas con tu pareja, con tus hijos, con tus padres… que finalmente no te llevan a ningún lado, los problemas no son eternos, siempre tienen solución, aunque en ocasiones no la veas pues es más fuerte tu miedo que tu Fe… mira hacia adelante y ve lo BENDECIDO y AMADO que eres por DIOS …
La Ecopsicosofía en el cuidado de sí y los ejercicios espirituales
Authors: Acosta Díaz Emilio 
Published: November 2023

El llamado a la comprensión de la realidad es un reto irrenunciable para el hombre, en todas las circunstancias y desde diversos ámbitos del conocimiento y actuar humanos en búsqueda de la verdad, en un nuevo despertar de la consciencia con la responsabilidad política global que requiere el momento histórico. En este ejercicio del pensamiento se propone la Ecopsicosofía, para abordar la realidad desde una visión integradora de las acciones del hombre y las relaciones que establece con el mundo, la casa común.
El artículo esboza el sentido y significado filosófico de la Ecopsicosofía y el ejercicio investigativo doctoral filosófico en el que se sustenta, con miras a brindar la oportunidad de aproximarse a la construcción de nuevos horizontes y estrategias en la dinámica de la comprensión y la construcción de un pensamiento coherente, global e integral que responda a los requerimientos e inquietudes más urgentes del hombre contemporáneo, desde dos ejes primordiales: el cuidado de sí y los ejercicios espirituales filosóficos.
Las aguas del Galeras
Authors: Enríquez Pantoja María Viviana , Ortega Yanguatin Luis Danilo 
Published: November 2023

La escasez de recursos hídricos es una problemática que tiende a aumentar constantemente, es por esto que diversas poblaciones a nivel mundial tratan de disminuir su impacto; tal es el caso del cabildo indígena del corregimiento de Genoy, en el municipio de Pasto, que de manera autónoma protege los cinco riachuelos o quebradas existentes en su territorio, de los cuales el 60% es de agua no potable (azufrada) y el otro 40% corresponde a los caudales utilizados para el consumo humano; en este sentido, se pretende analizar las prácticas de la comunidad del cabildo indígena del corregimiento de Genoy en función de la conservación de recursos hídricos naturales, mediante una investigación de corte cualitativo, hermenéutico, que evidencie la conservación de los recursos hídricos como una práctica con la que se siente comprometido el conjunto de la población del corregimiento de Genoy
Base de datos en Colombia
Authors: Gavilanes Acosta Luis Camilo 
Published: November 2023

Las bases de datos son una herramienta de innovación que continúa en desarrollo para las empresas que aspiran desarrollar estrategias competitivas con base en la información que brinda el mercado actualmente, es por lo que se tratará de explicar dicha herramienta, aparte de las ventajas y desventajas que puede traer consigo para las organizaciones que deseen implementarla en Colombia, debido a que hoy en día los datos ya son una ventaja competitiva en otros países, que permiten a cualquier tipo de organización segmentar, analizar y procesar por medio de diversos mecanismos.