bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory study on the effect of stress cycling pattern and rate on seismicity evolution
Authors: Naderloo M. , Veltmeijer A. , Jansen J. D. , Barnhoorn A. 
Published: October 2023

AbstractRecent laboratory and field studies suggest that temporal variations in injection patterns (e.g., cyclic injection) might trigger less seismicity than constant monotonic injection. This study presents results from uniaxial compressive experiments performed on Red Felser sandstone samples providing new information on the effect of stress pattern and rate on seismicity evolution. Red Felser sandstone samples were subjected to three stress patterns: cyclic recursive, cyclic progressive (CP), and monotonic stress. Three different stress rates (displacement controlled) were also applied: low, medium, and high rates of 10−4 mm/s, 5 × 10−4 mm/s, and 5 × 10−3 mm/s, respectively. Acoustic emission (AE) waveforms were recorded throughout the experiments using 11 AE transducers placed around the sample. Microseismicity analysis shows that (i) Cyclic stress patterns and especially cyclic progressive ones are characterized by a high number of AE events and lower maximum AE amplitude, (ii) among the three different stress patterns, the largest b-value (slope of the log frequency-magnitude distribution) resulted from the cyclic progressive (CP) stress pattern, (iii) by reducing the stress rate, the maximum AE energy and final mechanical strength both decrease significantly. In addition, stress rate remarkably affects the detailed AE signature of the events classified by the distribution of events in the average frequency (AF)—rise angle (RA) space. High stress rates increase the number of events with low AF and high RA signatures. Considering all elements of the AE analysis, it can be concluded that applying cyclic stress patterns in combination with low-stress rates may potentially lead to a more favourable induced seismicity effect in subsurface-related injection operations.
Joint Representation Learning with Generative Adversarial Imputation Network for Improved Classification of Longitudinal Data
Authors: Pingi Sharon Torao , Zhang Duoyi , Bashar Md Abul , Nayak Richi 
Published: October 2023

AbstractGenerative adversarial networks (GANs) have demonstrated their effectiveness in generating temporal data to fill in missing values, enhancing the classification performance of time series data. Longitudinal datasets encompass multivariate time series data with additional static features that contribute to sample variability over time. These datasets often encounter missing values due to factors such as irregular sampling. However, existing GAN-based imputation methods that address this type of data missingness often overlook the impact of static features on temporal observations and classification outcomes. This paper presents a novel method, fusion-aided imputer-classifier GAN (FaIC-GAN), tailored for longitudinal data classification. FaIC-GAN simultaneously leverages partially observed temporal data and static features to enhance imputation and classification learning. We present four multimodal fusion strategies that effectively extract correlated information from both static and temporal modalities. Our extensive experiments reveal that FaIC-GAN successfully exploits partially observed temporal data and static features, resulting in improved classification accuracy compared to unimodal models. Our post-additive and attention-based multimodal fusion approaches within the FaIC-GAN model consistently rank among the top three methods for classification.
… das dien sin leben ein spiegel und ein bild si
Authors: Wetzel René 
Published: October 2023

ZusammenfassungWie wird ein Begriff konzeptualisiert, für welchen kein eindeutiger sprachlicher Ausdruck zur Verfügung steht? Eine entsprechende Semantik muss sich zwangsläufig sprachlicher Bilder bedienen, um den abstrakten Begriff oder Aspekte daraus sicht- und begreifbar zu machen und gleichzeitig an der Bedeutungsbildung mitzuwirken. Im Fall der Responsibilität wird der Diskurs u. a. durch die Spiegelmetapher mit ihrer Vielfalt an Bedeutungs- und Assoziationsmöglichkeiten geprägt. Der responsible Mensch orientiert sich an ihm vor Augen gestellten Spiegel- oder Vor-Bildern und trägt Verantwortung dafür, dass er für andere selbst ein solches vor Augen gestelltes Bild wird. Auch die innere moralische Instanz des Gewissens kann mit dem Sprachbild des Spiegels zum Abgleich mit herrschenden ethischen Normen anregen und als Ergebnis Responsibilität einfordern, welche individualethischer, sozialethischer oder kosmologischer Natur sein kann. Darin sind sich der monastische und der höfische Responsibilisierungsdiskurs (als Beispiel dienen die Engelberger Predigten sowie der Welsche Gast Thomasins von Zerclaere) in ihrer grundsätzlichen Ausrichtung durchaus ähnlich, auch wenn sich in den Narrativen der beiden Kulturbereiche spezifische Unterschiede bemerkbar machen. In beiden Diskursen erfolgt eine (nur graduell unterschiedliche) Übertragung von Verantwortung von unten nach oben in der sozialen Hierarchie. Dabei wird stets auch die Rolle des freien Willens bei der Zuschreibung und Übernahme von Verantwortung verhandelt.
Investigating Learning Trajectories on Digital Attention Training Tasks in Primary School Children
Authors: Richmond Sally , Kirk Hannah , Cornish Kim , Spencer-Smith Megan 
Published: October 2023

AbstractAttention training programs have demonstrated potential for improving select cognitive skills and behaviors in children, but reported benefits are inconsistent. It is unclear whether variability in training benefits can be attributed to differences in children’s learning trajectories on training tasks over the intervention period. This study examined the functional form of learning trajectories on adaptive attention training tasks in primary school children, and potential associations between these learning trajectories and (a) pre-training child characteristics (general cognitive ability, hyperactivity, inattention, age) and (b) outcomes on untrained tasks from pre- to post-training (attention, hyperactivity, inattention). A total of 38 children (5–9 years) completed a 5-week attention training program in class. The training sessions involved four tasks targeting selective attention, sustained attention, inhibition, or interference control. Assessments were conducted pre- and immediately post-training. Based on non-linear mixed-effects models, the learning trajectories were best described by asymptotic regression, where the largest rate of improvement occurred initially, followed by gradual flattening out as task difficulty approached the asymptote. For the sustained attention training task, lower asymptotes predicted larger reductions in hyperactive behaviour from pre- to post-training. For the sustained and selective attention training tasks, age was associated with the asymptotes of the learning trajectories. Collectively, these findings suggest that learning trajectories on certain attention training tasks are associated with select child characteristics and training outcomes. It is of interest for future cognitive training studies to examine the learning trajectories of tasks targeting different skills to contribute understanding of the processes associated with cognitive training outcomes.
Designing Formative Assessment That Improves Teaching and Learning: What Can Be Learned from the Design Stories of Experienced Teachers?
Authors: van der Steen Janneke , van Schilt-Mol Tamara , van der Vleuten Cees , Joosten-ten Brinke Desirée 
Published: October 2023

AbstractThis article reports on findings of a qualitative study that investigated the difficulties teachers encounter while designing formative assessment plans and the strategies experienced teachers use to avoid those pitfalls. The pitfalls were identified through an analysis of formative assessment plans that searched for potential threats to alignment, decision-driven data collection, and room for adjustment and improvement. The main pitfalls in the design process occurred when teachers did not explicitly and coherently link all elements of their formative assessment plan or when they did not plan to effectively use information about student learning to improve teaching and learning. Through interviews with experienced teachers, we identified seven design strategies they used to design formative assessment plans that were aligned, consisted of decision-driven data collection, and left room for adjustment and improvement. However, these experienced teachers still encountered difficulties in determining how to formulate the right decisions for decision-driven data collection and how to provide students with enough room for improvement. Lessons learned from the design strategies of these experienced teachers are incorporated in design steps for formative assessment plans all teachers can use.
The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats
Authors: Haduch Anna , Bromek Ewa , Kuban Wojciech , Basińska-Ziobroń Agnieszka , Danek Przemysław J. , Alenina Natalia , Bader Michael , Daniel Władysława A. 
Published: October 2023

Abstract
Background
Liver cytochrome P450 (CYP) greatly contributes to the metabolism of endogenous substances and drugs. Recent studies have demonstrated that CYP expression in the liver is controlled by the central nervous system via hormonal pathways. In particular, the expression of hepatic CYPs is negatively regulated by the brain serotoninergic system. The present study aimed to investigate changes in the function of the main liver drug-metabolizing CYP enzymes as a result of serotonin depletion in the brain of aging rats, caused by knockout of brain tryptophan hydroxylase gene (TPH2-KO).

Methods
The hepatic CYP mRNA (qRT-PCR), protein level (Western blotting) and activity (HPLC), and serum hormone levels (ELISA) were measured in Dark Agouti wild-type (WT) male rats (mature 3.5-month-old and senescent 21-month-old) and in TPH2-KO senescent animals.

Results
The expression/activity of the studied CYPs decreased with age in the liver of wild-type rats. The deprivation of serotonin in the brain of aging males decreased the mRNA level of most of the studied CYPs (CYP1A/2A/2B/3A), and lowered the protein level of CYP2C11 and CYP3A. In contrast, the activities of CYP2C11, CYP3A and CYP2C6 were increased. The expression of cytochrome b5 decreased in aging rats, but increased in TPH2-deficient senescent animals. The serum concentration of growth hormone declined in the aged and further dropped down in TPH2-deficient senescent rats.

Conclusions
Rat liver cytochrome P450 functions deteriorate with age, which may impair drug metabolism. The TPH2 knockout, which deprives brain serotonin, affects cytochrome P450 expression and activity differently in mature and senescent male rats.
Ultraviolet sun exposure and sun protection behaviors in outdoor rock climbers
Authors: Gutiérrez-Manzanedo José V. , González-Montesinos José Luis , Aguilera-Arjona José , Rodríguez-Martínez Alba , Vaz-Pardal Carmen , España-Romero Vanesa , Rivas-Ruiz Francisco , Blázquez-Sánchez Nuria , De Gálvez-Aranda María Victoria , De Troya-Martín Magdalena 
Published: October 2023

Abstract
Background
Overexposure to sunlight and sunburn are the main preventable causes of skin cancer. Outdoor sports are associated with significant levels of sunlight exposure.

Aims
We sought to quantify the sun radiation exposure received by outdoor rock climbers and assess their sun exposure habits, sun protection behaviors, attitudes, and knowledge regarding skin cancer.

Methods
From April to June 2021, outdoor rock climbers contacted via email completed an online validated self-reported questionnaire on sun related habits, behaviors, attitudes and knowledge. As a pilot trial, ten participants wore a personal dosimeter during two outdoor climbing weekends in May and November 2021. Ambient ultraviolet radiation (UVR) was also recorded.

Results
A total of 217 outdoor rock climbers (103 women), mean age 36.8 ± 8.8 years (range 20–70 years) and median climbing practice per week of 8 h (IQR 7.5) were studied. Two in three (65.9%) participants reported at least one sunburn event during the previous rock climbing season. Of the survey respondents, 49.3% reported using sunscreen with SPF ≥ 15, 47% wore sunglasses, and 14.3% indicated they reapplied sunscreen every two hours. The median personal UVR dose measured during the two outdoor climbing weekends analyzed was 5.2 (IQR 1.8) and 8.8 (IQR 1.1) standard erythemal doses, respectively.

Conclusions
The high rates of sunburn, the elevated personal UVR measured and the clearly insufficient sun protection practices followed during rock climbing together with unsatisfactory attitudes towards tanning reveal the need to develop explicit sun protection campaigns and educational strategies to reduce the risk of skin cancer among the athletes studied.

Graphical abstract
Immunochemotherapy combined with novel agents for Richter syndrome: report of 3 cases
Authors: Xing Lijie , Wang Hui , Liu Dan , He Qiang , Li Zengjun 
Published: October 2023

Abstract
Objective
Richter syndrome (RS) occurs in approximately 2–10% of chronic lymphocytic leukemia (CLL) patients, more often during the disease course than at diagnosis, with a diffuse large B-cell Lymphoma (DLBCL) histology in 95% of cases. Despite great advances in the treatment of CLL in recent years, RS also develops in patients treated with novel agents, as summarized in our case report and review.

Methods
We summarized 3 patients with RS treated with immunochemotherapy combined with BTK inhibitor (BTKi) or BCL2 inhibitor (BCL2i) and reviewed the literature.

Results
Three RS patients were summarized. Patient 1 was transformed into DLBCL during dose reductions in ibrutinib and achieved bone marrow (BM) minimal residual disease (MRD)-negative complete response (CR) after rituximab etoposide, dexamethasone, doxorubicin, cyclophosphamide, and vincristine (R-EDOCH) combined with BTKi treatment and sustained progression-free survival (PFS) for more than 2 years. Patient 2, who transformed at the time of diagnosis, progressed after being treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), followed by PD1 antibody combined with cytosine, arabinoside, cisplatin and dexamethasone (DHAP) treatment and PD1 antibody combined with ifosfamide, carboplatin, and etoposide (ICE) treatment. Patient 2 achieved CR after treatment with rituximab, gemcitabine, and oxaliplatin (R-GemOx) combined with BTKi. Patient 3, who transformed at the time of diagnosis with CARD11, TP53, and ATM mutations, progressed after being treated with R-EDOCH combined with BTKi and achieved MRD-negative CR after treatment with R-GemOx and venetoclax, which has continued for 3 months.
We summarized new protocols utilizing targeted therapy, such as BTKi acalabrutinib, and checkpoint inhibition, and the potential role of precision medicine in future trials of RS treatment. The efficacy of these protocols as single agents or in combination with immunochemotherapy is currently being evaluated.

Conclusion
In our study, immunochemotherapy combined with BTKi or BCL2i achieved favorable efficacy in the treatment of RS. The treatments should be optimized by the combination of both chemotherapies and targeted therapy to develop a specific individual approach for each patient, according to previous treatment and biological characteristics.
Modification of 316L steel powders with bronze using high energy ball milling for use as a binder component in PBF-LB/M printing of diamond-metal matrix composites
Authors: Tillmann Wolfgang , Pinho Ferreira Manuel 
Published: October 2023

AbstractFor the processing of diamond-metal matrix composites, the powder bed fusion using a laser for metals (PBF-LB/M), represents a new promising method for the additive manufacturing of diamond tools for concrete and rock machining, even with more complicated geometries. Previous research activities show a strong tendency for cracking and delamination during the construction process of the samples. This behavior is caused by thermal residual stresses associated with the embedded diamonds. To control these negative effects on the process side, the volume energy density is reduced accordingly, which, however, led to increased pore formation. This publication deals with an approach on the material side to modify a 316L stainless steel base powder with an addition of 20 wt% bronze via a high energy ball milling (HEBM) process in such a way that a homogeneous solid solution phase is created. A significantly increasing of the melting interval and a decreasing of both solidus and liquidus temperature was observed, which can reduce pore formation in the PBF-LB/M-process. In addition, XRD-diffractometry and SEM/EDS-analysis showed that the homogeneous solid solution phase of this alloyed powder segregates again into Fe- and Cu-rich phases when heated up to the melting point.
The relationship between atmospheric temperature inversion and urban air pollution characteristics: a case study of Tehran, Iran
Authors: Nejad Meysam Toulabi , Ghalehteimouri Kamran Jafarpour , Talkhabi Hamidreza , Dolatshahi Zeynab 
Published: October 2023

AbstractThis study conducts a comprehensive evaluation of air pollution in Tehran, focusing on its origins and potential remedial measures. Data from the Mehrabad station in Tehran were meticulously analyzed to scrutinize the spatiotemporal dynamics over a three-year period. Leveraging the Universal Radio Sound Observation (RAOB) program, we probed atmospheric attributes up to 750 m on specific critical dates: January 22, 2014; January 25, 2015; and November 27, 2016, which represent peak pollution events. Employing mathematical models, we scrutinized air temperature inversion profiles and applied the Heffter method to gauge the impact of atmospheric inversions on Tehran's air quality. Our investigation unequivocally identified January 25, 2015, as the most polluted date, unveiling precise atmospheric conditions during a radiation inversion, encompassing altitudes, temperatures, humidity, wind speed, and inversion depth. This research significantly advances our comprehension of the intricate interplay between atmospheric inversions and air pollution. It provides critical insights that can inform the development of targeted strategies to mitigate air quality issues not only in Tehran but also in analogous urban settings worldwide.
Analysis of a 131-year longitudinal dataset of the Eurasian otter Lutra lutra in Hong Kong: implications for conservation
Authors: Hui Michael Ka Yiu , Chan Bosco Pui Lok 
Published: October 2023

AbstractHong Kong is one of the busiest metropolises, and the Eurasian otter Lutra lutra is one of its most threatened species. We collected published data for 1890–2020 to document changes in local otter abundance and distribution over time. The 108 records revealed new distribution data and showed that decline began as early as the 1930s. The local Eurasian otter is strongly associated with coastal and alluvial wetlands, and its last refugium, the Yuen Long floodplain draining the Mai Po Inner Deep Bay Ramsar Site, has always been a critical habitat. Our analysis suggests that hunting is unlikely to be a major cause of the otter's decline. Rather, dependence on lowland wetlands makes it particularly susceptible to habitat loss caused by increasing urbanization. Auxiliary infrastructures and water pollution have also exacerbated wetland degradation to the detriment of otters and their prey. There is a need for greater cooperation amongst government agencies and landowners to guarantee otter survival: priority steps include the establishment of additional and interconnected wetland reserves, better stakeholder engagement and enforcement efficiency to tackle entrenched pollution problems, and flood prevention schemes that preserve or restore functional riverine ecosystems within critical otter habitats. The current otter distribution range has been earmarked for development in a government-led mega urbanization plan; the plight of the local Eurasian otter needs to be widely publicized to garner stakeholders' support and galvanize immediate conservation actions across society.
Bicategorical type theory: semantics and syntax
Authors: Ahrens Benedikt , North Paige Randall , van der Weide Niels 
Published: October 2023

AbstractWe develop semantics and syntax for bicategorical type theory. Bicategorical type theory features contexts, types, terms, and directed reductions between terms. This type theory is naturally interpreted in a class of structured bicategories. We start by developing the semantics, in the form of comprehension bicategories. Examples of comprehension bicategories are plentiful; we study both specific examples as well as classes of examples constructed from other data. From the notion of comprehension bicategory, we extract the syntax of bicategorical type theory, that is, judgment forms and structural inference rules. We prove soundness of the rules by giving an interpretation in any comprehension bicategory. The semantic aspects of our work are fully checked in the Coq proof assistant, based on the UniMath library.
Boundary Conditions for the Parametric Kalman Filter Forecast
Authors: Sabathier M. , Pannekoucke O. , Maget V. , Dahmen N. 
Published: October 2023

AbstractThis paper is a contribution to the exploration of the parametric Kalman filter (PKF), which is an approximation of the Kalman filter, where the error covariances are approximated by a covariance model. Here we focus on the covariance model parameterized from the variance and the anisotropy of the local correlations, and whose parameters dynamics provides a proxy for the full error‐covariance dynamics. For this covariance model, we aim to provide the boundary condition to specify in the prediction of PKF for bounded domains, focusing on Dirichlet and Neumann conditions when they are prescribed for the physical dynamics. An ensemble validation is proposed for the transport equation and for the heterogeneous diffusion equation over a bounded 1D domain. This ensemble validation requires to specify the auto‐correlation time‐scale needed to populate boundary perturbation that leads to prescribed uncertainty characteristics. The numerical simulations show that the PKF is able to reproduce the uncertainty diagnosed from the ensemble of forecast appropriately perturbed on the boundaries, which show the ability of the PKF to handle boundaries in the prediction of the uncertainties. It results that Dirichlet condition on the physical dynamics implies Dirichlet condition on the variance and on the anisotropy.
Global Estimation of the Eddy Kinetic Energy Dissipation From a Diagnostic Energy Balance
Authors: Torres Romain , Waldman Robin , Mak Julian , Séférian Roland 
Published: October 2023

AbstractMesoscale eddies dominate the ocean kinetic energy reservoir. However, how and where this energy flows out from the mesoscale remains uncertain. Here, a simplified mesoscale energy budget is used where sources due to baroclinic instability are balanced by all the dissipative processes approximated as a linear damping rate. In this simple model, the eddy kinetic energy (EKE) dissipation is computed from a climatological mean field of density and satellite altimeter data, and is proportional to an eddy efficiency parameter α. Assuming an eddy efficiency of α = 0.1, we find a global EKE dissipation rate of 0.66 ± 0.19 TW. The results show an intense dissipation near western boundary currents and in the Antarctic Circumpolar Current, where both large levels of energy and baroclinic conversion occur. The resulting geographical distribution of the dissipation rate brings new insights for closing the ocean kinetic energy budget, as well as constraining future mesoscale parameterizations and associated mixing processes.