bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promotion of hydrogen evolution from seawater via poly(aniline-co-4-nitroaniline) combined with 3D nickel nanoparticles
Authors: Moradi-Alavian Saleh , Kazempour Amir , Mirzaei-Saatlo Meysam , Ashassi-Sorkhabi Habib , Mehrdad Abbas , Asghari Elnaz , Lamb Jacob J. , Pollet Bruno G. 
Published: December 2023

AbstractThis work reports the synthesis of poly (aniline-co-4-nitroaniline) deposited on a three-dimensional nanostructured nickel (3D-Ni) film, where both layers were fabricated via potentiostatic electrodeposition. The obtained electrocatalyst exhibited excellent electrochemical activity for the Hydrogen Evolution Reaction (HER) with small overpotentials of − 195 and − 325 mV at − 10 and − 100 mAcm−2, respectively, and a low Tafel slope of 53.3 mV dec−1 in seawater. Additionally, the electrocatalyst exhibited good stability after 72 h operation under a constant potential of − 1.9 V vs. RHE. The efficient HER performance of the as-prepared catalyst was found to originate from the synergy between the conducting polymer and three-dimensional nickel nanoparticles with a large electrochemical active surface area. Moreover, the results obtained from electrochemical impedance spectroscopy (EIS) measurements revealed that the presence of 3D-Ni layer improved the kinetics of HER by reducing the charge transfer resistance for the electrocatalyst.
Infusion of propofol with bispectral index monitoring does not reduce the amount of propofol used during transvaginal oocyte retrieval procedure
Authors: Bilgen Sevgi , Erdogan Dilek , Ökten Sabri Berkem 
Published: December 2023

AbstractIn our study we aimed to investigate whether the use of bispectral index (BIS) monitoring would decrease total propofol consumption during the transvaginal oocyte retrieval procedure. This was a prospective, randomized, controlled, parallel-group clinical trial. The study was conducted in the operating room, and postoperative recovery room. One hundred and thirty, American Society of Anesthesiologists (ASA) I–II patients, over age 18, undergoing transvaginal oocyte retrieval were included in this study. All patients were administered 2 μg/kg fentanyl, and 2 mg/kg propofol for the induction of anesthesia. The patients were divided into two groups. Patients in the group bolus were given 0.5 mg/kg of propofol when necessary, according to the observer's range of motion. Patients in the group BIS were given 10 mg/kg/h propofol infusion adjusted to keep the BIS value between 40 and 60. The primary outcome was the total dose of propofol administered per patient. The secondary outcomes were the time to reach the value of 5 on the Modified Observer's Assessment of Alertness Sedation Scale (MOASs), the time to reach Post Anesthetic Discharge Scoring System (PADSS) ≥ 9 of the patients, satisfaction of the patient, and the gynecologist. The amount of total propofol was higher in the group BIS than in the group bolus administered according to the patient's clinic. There was no difference in the time to reach the value of 5 on the MOASs between the groups. The time to reach PADSS ≥ 9 was longer in the group BIS than in the group bolus. There was no difference between the two groups in terms of the satisfaction of the patient and the gynecologist. Administration of propofol as an infusion with BIS monitoring did not reduce the amount of propofol administered to patients during transvaginal oocyte retrieval.Clinical trial registration number: NCT05631925—30/11/2022.
Enhancing cochlear duct length estimation by incorporating second-turn parameters
Authors: Alahmadi Asma , Abdelsamad Yassin , Dhanasingh Anandhan , Almuhawas Fida , Alsanosi Abdulrahman 
Published: December 2023

AbstractEstimating insertion depth, cochlear duct length (CDL), and other inner ear parameters is vital to optimizing cochlear implantation outcomes. Most current formulas use only the basal turn dimensions for CDL prediction. In this study, we investigated the importance of the second turn parameters in estimating CDL. Two experienced neuro-otologists blindly used segmentation software to measure (in mm) cochlear parameters, including basal turn diameter (A), basal turn width (B), second-turn diameter (A2), second-turn width (B2), CDL, first-turn length, and second-turn length (STL). These readings were taken from 33 computed tomography (CT) images of temporal bones from anatomically normal ears. We constructed regression models using A, B, A2, and B2 values fitted to CDL, two-turn length, and five-fold cross-validation to ensure model validity. CDL, A value, and STL were longer in males than in females. The mean B2/A2 ratio was 0.91 ± 0.06. Adding A2 and B2 values improved CDL prediction accuracy to 86.11%. Therefore, we propose a new formula for more accurate CDL estimation using A, B, A2, and B2 values. In conclusion, the findings of this study revealed a notable improvement in the prediction of two-turn length (2TL), and CDL by clinically appreciable margins upon adding A2 and B2 values to the prediction formulas.
In-silico study of drug delivery to atherosclerosis in the human carotid artery using metal–organic frameworks based on adhesion of nanocarriers
Authors: Shamloo Amir , Naseri Tahoora , Rahbary Ali , Bakhtiari Mohammad Ali , Ebrahimi Sina , Mirafzal Iman 
Published: December 2023

AbstractThis study investigates nanocarriers (NCs) for drug delivery targeting carotid artery atherosclerosis. This targeted drug delivery mechanism is based on ligand–receptor bindings facilitated by coating NCs with P-selectin aptamers, which exhibit high affinities for P-selectin plaque receptors. Recognizing the significant advantages of metal–organic frameworks (MOFs), such as their high drug-loading percentages, we chose them as nanocarriers for this research. Our evaluation considers critical factors: NC surface density (the number of attached nanocarriers per unit of plaque area), toxicity (percentage of NCs missing the target), and efficient drug transfer to plaque tissue. Employing molecular dynamics (MD) for drug loading calculations via van der Waals interactions and computational fluid dynamics (CFD) for toxicity, surface density, and drug transfer assessments, we achieve a comprehensive analysis. A cardiac cycle-based metric guides optimal MOF release conditions, establishing an ideal dosage of 600 NCs per cycle. MOF-801 exhibits outstanding drug delivery performance, particularly in plaque targeting. While a magnetic field enhances NC adhesion, its impact on drug transfer is limited, emphasizing the need for further optimization in magnetic targeting for NC-based therapies. This study provides crucial insights into NC drug delivery performance in carotid artery atherosclerosis, advancing the field of targeted drug delivery for atherosclerosis treatment.
Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation
Authors: Arnold Emily L. , Elarnaut Farid , Downes David , Evans J. Paul O. , Greenwood Charlene , Rogers Keith D. 
Published: December 2023

AbstractBone quality is commonly used to diagnose bone diseases such as osteoporosis, with many studies focusing on microarchitecture for fracture prediction. In this study a bovine distal femur was imaged using both micro-computed tomography (µCT) and tomosynthesis using focal construct geometry (FCG) for comparison of microarchitectural parameters. Six regions of interest (ROIs) were compared between the two imaging modalities, with both global and adaptive methods used to binarize the images. FCG images were downsampled to the same pixel size as the µCT images. Bone morphometrics were determined using BoneJ, for each imaging modality, binarization technique and ROI. Bone area/total area was found to have few significant differences between FCG and µCT (p < 0.05 for two of six ROIs). Fractal Dimension had only one significant difference (p < 0.05 for one of six ROIs) between µCT and downsampled FCG (where pixel size was equalized). Trabecular thickness and trabecular spacing were observed to follow trends as observed for the corresponding µCT images, although many absolute values were significantly different (p < 0.05 for between one and six ROIs depending on image types used). This study demonstrates the utility of tomosynthesis for measurement of microarchitectural morphometrics.
Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis
Authors: Alnasser Ammar , Alhumrran Hassan , Alfehaid Mustafa , Alhamoud Mustafa , Albunaian Nada , Ferwana Mazen 
Published: December 2023

AbstractTension-type headache (TTH) is the most common type of headache worldwide. It is defined and classified according to the International Classification of Headache Disorders. TTH is treated with over-the-counter medications, mostly paracetamol or ibuprofen. The purpose was to assess the effectiveness of paracetamol versus ibuprofen in treating episodic tension-type headache (ETTH) through direct and indirect comparisons of randomized controlled trials (RCTs). We included RCTs comparing paracetamol with a placebo, ibuprofen with a placebo, or paracetamol with ibuprofen for acute ETTH treatment that were published between 1988 and 2022. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and the Web of Science. The Cochrane Collaboration risk of bias tool was used to assess the risk of bias. We identified 14 studies including 6521 people with ETTH. None of the studies had a low risk of bias for all domains; this was most likely due to inadequate reporting and a small sample size. Ibuprofen (odds ratio (OR): 1.73, 95% confidence interval (CI): 1.17–2.56) showed better efficacy than paracetamol (OR: 1.62, 95% CI 1.24–2.13) for pain-free status at 2 h, while paracetamol (OR: 1.42, 95% CI 0.87–2.30) showed better efficacy than ibuprofen (OR: 1.20, 95% CI 0.58–2.48) for pain-free status at 1 h. Paracetamol was associated with the lowest likelihood of rescue medication use (OR: 0.49, 95% CI 0.37–0.65). Ibuprofen was associated with a lower likelihood of the occurrence of any events and gastrointestinal adverse events compared with placebo and paracetamol (OR: 0.95, 95% CI 0.64–1.41 and OR: 0.81, 95% CI 0.44–1.50, respectively). Paracetamol and ibuprofen showed better efficacy than placebo in treating ETTH; there was no statistically significant difference in efficacy between the two drugs. For individuals at a higher risk (like renal insufficiency or risk of GI bleeding), paracetamol may be considered as a preferred option instead of Ibuprofen. Further meta-analyses of head-to-head trials are needed for direct comparisons in the future.PROSPERO registration number: CRD42022340936.
A real-world study on the effectiveness of BBIBP-CorV and CoronaVac in Nanjing area
Authors: Huang Min , Jia Lu , Ye Sheng , Pang Rongrong , Ma Chengping , Zhang Jiajuan , Dai Shuming , Zhang Ke , Dai Yudong , Fu Qiang , Zhang Libo 
Published: December 2023

AbstractSince the advent of COVID-19 vaccine, the long-term monitoring and evaluation of vaccine effectiveness worldwide has never stopped. Real-world research of the mainstream vaccines in China (BBIBP-CorV and CoronaVac) is extremely valuable as a supplement to clinical research data. Venous blood of this study was collected from 111 blood donors and from 6 volunteers, who had received 2 doses of SAR-CoV-2 vaccine. Cross-sectional study and cohort study was adopted. Venous blood of 11 COVID-19 convalescent plasma donors was collected as a positive control. The seroconversion rate of neutralizing antibodies in 111 vaccine recipients was 90.99% (101/111); The level of SAR-CoV-2 antibodies peaked around 28 days after inoculation, then fast descended followed by gentle descended until it was still detectable around 280 days later. The changes in antibody levels were similar to those of the 6 participants and those of convalescent plasma donors after infection. 5 of the 6 participants still maintained a high level of neutralizing antibodies (> 60% of the peak value) around 28 days after receiving 2 doses of vaccine; one participant had an antibody reaction that was almost always negative for 4 weeks. BBIBP-CorV and CoronaVac can produce good immune effects in most vaccinators aged 20 to 59 years in Nanjing area. Nevertheless, significant individual discrepancies of the humoral immunity are still existed.
The Use of Electronic Health Records for Behavioral Phenotyping of School-Age Children With Unilateral Hearing Loss: A Methodological Approach
Authors: Davis Hilary , Tang Leigh Anne , M. Picou Erin , Bastarache Lisa , Tharpe Anne Marie 
Published: December 2023

Purpose:
This methodological study describes a technique for extracting information from de-identified electronic health records (EHRs) to identify occurrences of permanent unilateral hearing loss (UHL) and associated educational comorbidities.

Method:
This was an exploratory methodological study utilizing approximately 3.3 million de-identified medical records. Structured and unstructured data were extracted using both automated and manual methods. When both methods were available, positive and negative predictive values were calculated to evaluate the utility of using automated methods.

Results:
We defined a cohort of 471 records that met our criteria of school-age children with permanent UHL and no additional significant disabilities/diagnoses. Fifty-one percent of the children reflected in this cohort had indicators of adverse educational progress, defined as documentation of receiving educational services, speech-language therapy, and/or parental/teacher concern, with 12% of records reflecting overlapping services/concerns. Negative predictive values were generally high and positive predictive values were generally low, suggesting automated searches are useful for excluding factors of interest, but not finding them.

Conclusions:
This study demonstrates the feasibility of using EHRs in examining UHL in school-age children. By restricting our cohort to individuals who were seen in audiology clinic, we were able to capture variables such as educational difficulty that are not routinely ascertained in medical contexts. The proportion of children in this cohort demonstrating a marker of adverse educational progress is consistent with numerous prior observational studies, thus providing validity to this ascertainment approach. We describe challenges encountered in creating this cohort and detail our hybrid approach to ascertaining key variables accurately.
Fault diagnosis for multiple current sensors in grid‐connected inverter based on average modulation voltage
Authors: Zhang Fan , Zhang Zhiwei , Jin Guangfeng , Wang Tianzhen , Han Jingang , Razik Hubert , Wang Yide 
Published: December 2023

AbstractGrid‐connected inverters are the core equipment in the renewable power system. There are multiple current sensors which may affect the driving module of the switch in inverter. In multiple current sensor fault diagnosis, the coupling between fault components makes fault diagnosis difficult. This paper presents an offset fault diagnosis method of multiple current sensors based on the average modulation voltage model. Based on the influence of current sensor offset fault in the system, the average modulation voltage model is established in three‐phase stationary coordinates. The difference between the measured value of the current and the actual value is estimated through the model when the offset fault occurs. And then the fault is located. Experimental results show that the fault can be located accurately and fault tolerant control can be performed by this method when there are offset faults in multiple sensors simultaneously.
Resilience enhancement of distribution networks based on demand response under extreme scenarios
Authors: Xu Gang , Guo Zixuan 
Published: December 2023

AbstractIn the context of rare but high‐impact extreme scenarios, such as natural disasters, it is crucial to utilize all available resources, including microgrids and distributed power sources, to restore critical loads in the distribution network as much as possible. This paper proposes a two‐stage resilience enhancement strategy for distribution networks considering post‐disaster topology reconstruction and demand response, aiming to facilitate the recovery of critical loads after disasters. In the first stage, a heuristic algorithm is introduced to determine the post‐disaster topology of the distribution network. In the second stage, by employing a step‐wise elastic load curve, user demand response is incorporated to maximize the socio‐economic value of the restoration, and resilience metrics are computed. Finally, the effectiveness of the proposed resilience restoration strategy is validated through simulations on Case33 and Case69 systems.
Waste valorization in winery and distillery industry by producing biofertilizers and organic amendments
Authors: Mendoza K. , Linares V. , Hatta B. , Tinoco Y. , Alvarado J. , Di Laura A. 
Published: December 2023

Resumen
La industria vitivinícola y de destilación de bebidas espirituosas generan una notable cantidad de subproductos y residuos, cuya gestión inadecuada puede generar problemas socioeconómicos y riesgos ambientales debido a algunas características de disponibilidad estacional y elementos contaminantes. Tradicionalmente, las estrategias de valorización se han enfocado en el compostaje, para uso directo como mejorador de suelos en el viñedo. Sin embargo, este proceso requiere un tiempo prolongado y gran disposición de espacio libre (aeróbico), pudiendo causar fitotoxicidad y un efecto antimicrobiano. Una estrategia alternativa de tratamiento de estos residuos orgánicos es la digestión anaeróbica, después de la cual, en un periodo menor a 25 días y en una reducida área de trabajo, se obtienen dos digestatos: un líquido y un sólido, aptos para el uso agrícola en el viñedo. El objetivo del presente estudio fue evaluar la factibilidad de aprovechar las lías de vinificación y las vinazas de destilación para la elaboración de biofertilizantes y enmiendas orgánicas mediante digestión anaeróbica usando consorcios microbianos y estimar su valorización económica a mediana escala para una bodega vitivinícola del valle de Cañete (Perú). Se monitoreó la evolución del proceso de digestión (pH, Conductividad Eléctrica y Temperatura) para finalmente realizar una caracterización fisicoquímica y microbiológica de los digestatos obtenidos. Los resultados muestran que los productos elaborados presentan una significativa concentración de materia orgánica y fitonutrientes (Nitrógeno, Fosforo, Potasio, etc.) en un medio ligeramente ácido (pH entre 3.8 y 5.8), debido a la presencia de algunas especies de bacterias acido-lácticas y Bacillus, lo que podría conferirles propiedades como bioestimulantes y agentes de biocontrol. La estabilidad de los productos (pH, color y olor) fue evaluada durante 30 días más, mostrando excelentes condiciones higiénicas, debido a la ausencia de microorganismos patógenos, posibilitando su incorporación junto a otras enmiendas durante la mitad de la temporada vitícola. Por lo tanto, la valorización de estos subproductos y residuos vitivinícolas en la producción de biofertilizantes y enmiendas orgánicas para uso agrícola, podría suplir en gran parte el uso de fertilización sintética y recuperar la fertilidad del suelo. Los beneficios socio-económicos y ambientales serían múltiples, dentro de un enfoque de transición agroecológica y de economía circular.
Contraste entre despampanado y aclareo de racimos, aplicados antes del envero, en la respuesta vegetativa, productiva y cualitativa del cv. Verdejo
Authors: Yuste Jesús , Martínez-Porro Daniel 
Published: December 2023

Resumen
El efecto sumidero de la uva frente a la superficie foliar, como fuente de fotosintatos, es un aspecto muy debatido en cuanto a la repercusión que puede tener en el desarrollo del viñedo y en la calidad de la uva. En ciertas zonas, la limitación del nivel productivo es argumentado como factor principal para alcanzar niveles de alta calidad en el vino, pero se conoce poco sobre los efectos que las distintas operaciones reguladoras pueden tener en variedades blancas de vid. Así, el trabajo persigue contrastar la respuesta de la cepa a la aplicación de dos alternativas de regulación de cosecha: aclareo de racimos y despampanado, aplicadas en la fase inmediatamente anterior al envero, en el cv. Verdejo, en España.
Durante el periodo 2017-2019, la respuesta productiva y cualitativa del cv. Verdejo, sobre 110-R, fue estudiada tras aplicar, en fase de pre-envero, los tratamientos experimentales: AR, aclareo de racimos (respetando 1 racimo en cada pámpano); DP, despampanado (eliminando un pámpano en cada pulgar y respetando íntegramente el otro pámpano). El diseño experimental es en 4 bloques al azar, con parcela elemental de 12 cepas de control, en un viñedo conducido en espaldera, plantado en 2012, a 2,8 x 1,4 m, y podado en cordón Royat bilateral con 8 pulgares de 2 yemas por cepa.
El desarrollo vegetativo se vio significativamente afectado por el despampanado con respecto al aclareo de racimos, reduciendo el peso de madera de poda casi un 40%, a pesar del aumento medio del 16% del peso del sarmiento. La producción de uva se vio reducida por el despampanado una media del 11%, como consecuencia, sobre todo, de la reducción del número de racimos por cepa, así como de la ligera disminución del peso del racimo. La concentración de azúcares, el pH, el ácido málico y el contenido de potasio se vieron ligeramente reducidos por el despampanado con respecto al aclareo, mientras que la acidez titulable y el ácido tartárico resultaron algo mayores. En definitiva, la eliminación de la mitad de los pámpanos, que conlleva la reducción de la relación fuente-sumidero con respecto al aclareo de racimos, ha limitado ligeramente el desarrollo de diversos componentes del rendimiento, así como la concentración de azúcares, de ácido málico y de potasio, a la vez que el pH, favoreciendo la acidez total en la uva. La elección de la técnica de regulación productiva dependerá de los aspectos cualitativos que se quieran potenciar y de la disponibilidad hídrica para el viñedo, pues el despampanado descarga más la expresión vegetativa, aliviando el posible estrés hídrico, que el aclareo directo de racimos.