bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric-type follicular lymphoma in a Crohn’s disease patient receiving anti-α4β7-integrin therapy: A case report
Authors: Yerigeri Keval , Buhtoiarov Ilia 
Published: November 2023

BACKGROUND
Patients with autoimmune conditions receiving immunosuppressants are at risk of non-Hodgkin lymphomas (NHL). Vedolizumab (anti-α4β7-integrin antibody), a treatment-of-choice for Crohn’s disease (CD), reduces inflammatory lymphocyte trafficking into the intestinal mucosa. This effect is believed to be confined to the colon.
CASE SUMMARY
We report the case of a CD patient on vedolizumab for five years who developed pediatric-type follicular lymphoma. Work-up prior to therapy revealed a reduction in circulating T-lymphocytes and their suppressed response to mitogens. Rituximab, cyclophosphamide, vincristine, and prednisone chemo-immunotherapy resulted in durable lymphoma remission, and vedolizumab treatment was continued. While the patient’s T-lymphocyte population and immunoglobulin production recovered, the T-lymphocyte mitogen response remained suppressed.
CONCLUSION
This patient’s NHL may be linked to receiving anti-α4β7 therapy. Further research could be beneficial to determine if proactive surveillance for NHL and other systemic diseases is indicated in patients on vedolizumab.
PUSAT SENI BUDAYA SIMEULUE DI KOTA SINABANG
Authors: Wahyuni Nur , Aidina Faiza 
Published: November 2023

Simeulue memiliki berbagai macam seni budaya yang khas, yaitu seni nandong dan debus yang sejak lama sudah ada dan selalu diajarkan dari generasi ke generasi dan seiring berjalannya waktu seni budaya semakin dikembangkan yaitu seperti tari silongor dan mangasila, yang mana dulu hanya merupakan sebuah lagu daerah Simeulue. Di Simeulue saat ini belum mempunyai sebuah wadah atau tempat yang memiliki fasilitas yang layak untuk menampung masyarakat, serta sanggar-sanggar seni untuk mempertunjukan maupun mengembangkan kemampuan seni budaya yang dimiliki. Selain itu adanya Pusat Seni Budaya juga akan menampung layanan informasi seputar pariwisata (Tourism Information Center), dan juga sekaligus sebagai promosi Simeulue ke luar daerah. Pusat Seni Budaya Simeulue yang akan direncanakan berada di ibu kota Kabupaten Simeulue, yaitu Sinabang.Pusat Seni Budaya Simeulue di Kota Sinabang yang akan direncanakan termasuk kedalam klasifikasi Kabupaten. Pendekatan tema Arsitektur Neo-Vernakular untuk menghadirkan keselarasan antara kebiasaan masyarakat dengan seni budaya Simeulue. Pengembangan adat istiadat yang dimiliki oleh Simeulue, seperti motif khas milik Simeulue yaitu mata-mata, batik khas Simeulue, dan rumah adat tradisional Simeulue.Dengan analisis angin, matahari, dan hujan yang disesuaikan dengan keadaan di Simeulue. Luas lahan untuk perencanaan Pusat Seni Budaya Simeulue di Kota Sinabang ini 27.000 m², Massa bangunan yang direncanakan menggunakan pola massa tunggal. Koefisien Dasar Bangunan (KDB) 40% yaitu 7,200 m² dan ketinggian bangunan yaitu 20.000 m. Dengan fasilitas-fasilitas utama seperti Auditorium dan Amphiteather dan fasilitas pendukung Tourism Information Center, perpustakaan seni, ATM Center, Studio Seni dan fasilitas lainnya yang menjadikan pusat seni budaya menjadi lebih lengkap dan memberi manfaat lebih kepada pengunjung Pusat Seni Budaya Simeulue di Kota Sinabang.
KARYA ARSITEKTUR EKSPRESIONISME DUNIA
Authors: Marlina Henny , Arianti Reza Fitri 
Published: November 2023

Sebagai bagian dari kebudayaan manusia, arsitektur berkaitan dengan segi kehidupan, yang dapat ditinjau dari empat sisi yaitu seni, teknik, ruang dan sejarah. Dari sisi seni, arsitektur mencakup seni bangunan yang diimplementasikan dalam bentuk dan dekorasi. Dari sisi teknik, arsitektur diartikan sebagai sistem yang digunakan untuk merancang kontruksi dan struktur serta nilai estetika suatu bangunan. Ditinjau dari sisi ruang, arsitektur mencakup upaya pemenuhan ruang. Sedangkan dalam tinjauan sejarah dan geografi, arsitektur mencakup peninggalan sejarah dalam suatu batasan waktu dan tempat. Perkembangan arsitektur tidak terlepas dari perkembangan budaya yang semakin lama semakin kompleks mengikuti perkembangan peradaban. Sebagai salah satu aliran yang berkembang di Eropa pada awal abad ke-20, langgam Arsitektur Ekspresionis diilhami dari novel-novel dan roman-roman yang terkadang menggunakan material yang tidak lazim digunakan pada saat itu seperti batu bata, baja dan kaca. Ekspresionisme dianalogikan sebagai bagian dari linguistik, di mana dalam hal ini bangunan dianggap sebagai suatu media yang dapat digunakan oleh arsitek untuk mengungkapkan kebebasan dalam sikap dan ekspresinya, sehingga walaupun suatu karya arsitektur ekspresionis memiliki ciri khas namun tetap terlihat sederhana.
PERPUSTAKAAN MODERN DI SABANG
Authors: Usman Nasruna , Aini Qurratul 
Published: November 2023

Pengunjung perpustakaan di Kota Sabang berdasarkan badan perpustakaan daerah sangat minim, yaitu mencapai 11% dari jumlah penduduk per tahunnya. Perpustakaan yang ada di Kota Sabang berupa perpustakaan keliling, perpustakaan sekolah dan perpustakaan desa yang pengelolaannya kurang maksimal. Kondisi ketidaknyaman untuk membaca pun tidak tercapai serta media pelayanan masih menggunakan sistem manual atau belum menggunakan sistem teknologi digital. Untuk itu diperlukan perencanaan perpustakaan yang dapat menumbuhkan kembali budaya membaca di perpustakaan dengan sarana dan prasarana yang memadai. Lokasi perencanaan Perpustakaan Modern terletak di Sabang hill, Sukakarya, Sabang, Aceh, Indonesia.Perpustakaan modern yang akan didirikan termasuk kedalam klasifikasi Perpustakaan Umum dan tergolong kedalam perpustakaan Terotomasi. pendekatan tema Arsitektur Postmodern yang bertujuan untuk mengangkat kembali nilai kontekstual dan lokalitas yang ada di lingkungan sekitar. Pada perencanaan ini disertai dengan Analisis-analisis yang di pakai berupa analisis fungsional, analisis tapak atau lingkungan dan analisis bangunan.Bangunan perpustakaan modern ini ditransformasikan dari bentuk buku serta adanya penambahan bentuk setengah dan seperempat lingkaran di sisi kiri dan kanannya. Luas lahan untuk perpustakaan modern di Sabang ini 29.100 m², Massa bangunan yang direncanakan menggunakan pola massa tunggal. Koefisien Dasar Bangunan (KDB) 80% yaitu 23,280 m² dan Koefisien Lantai Bangunan (KLB) 2,4 dikali dengan luas lahan tersedia yaitu 69,840 m². Dengan fasilitas-fasilitas seperti taman baca terbuka, ruang koleksi buku, ruang digital, pustaka langka, dll.
Myxosporeans of greening fish of the Far Eastern seas
Authors: Aseeva Nadezhda , Smirnov Andrey 
Published: November 2023

The infection of three species of greenlings of the genus Hexagrammos, and two species of single-finned greenlings of the genus Pleurogrammus, was examined by myxosporeans.
In the myxosporeans fauna of greening fish, 6 species of myxosporeans were found: Sphaeromyxa hexagrammi, Zschokkella russelli, Ceratomyxa azonusi, Alataspora bialata, Kudoa azoni, Kudoa sp.
At the same, three species (S. hexagrammi, C. azonusi, K. azoni) are specific only to greenling fish. Two species (Z. russelli, A. bialata) are broadly specific, Kudoa sp. not determined to species
It was established that in the common greenlings the infection with myxosporeans was low, and the composition of the fauna was poor. The one-finned greenlings, in contrast to the common-finned greenlings, were more infected and had more myxosporeans species in their fauna. But both greenlings are dominated by the gallbladder species Sphaeromyxa hexagrammi, and muscle parasites of the genus Kudoa (K. azoni, K sp.), but the nature of infestation and distribution across the study areas are very different. First of all, with the biology of these greenlings. A smaller degree of differences in the common greenlings in the expansion of invasion by various species of myxosporeans less ecological plasticity of these species, compared to the single-finned greenlings.
El rol del Liderazgo Sistémico en Instituciones de Educación Superior en México
Authors: Vázquez Mendoza José Hugo , Vázquez Martínez Nallely , Vázquez Martínez Rosa Alejandra 
Published: November 2023

Este artículo pretende respaldar una perspectiva más extensa sobre el rol del liderazgo en instituciones de educación superior mexicanas y su entorno. El artículo investiga el concepto su relevancia y antecedentes, el fin es contribuir teóricamente en el conocimiento del liderazgo sistémico que suele utilizarse con gran continuidad en las instituciones de educación superior en México, de esta manera da pie a trabajar sistemática y sinérgicamente entre los miembros, hasta transformarse en un equipo de trabajo que marcha hacia lo sostenible, por lo tanto profundizan continuamente desde sus propias fortalezas y potencialidades para crear práctica gerenciales con base en un liderazgo integrador con el fin de alcanzar la mayor efectividad posible en el cumplimiento de las metas planteadas. Es el propósito de este artículo ampliar los conocimientos y hallazgos sobre el rol del liderazgo sistémico en instituciones de educación superior en México.
STUDI DESKRIPTIF: EVALUASI PEMBELAJARAN IPS SEKOLAH DASAR MELALUI APLIKASI QUIZIZZ
Authors: Andy Dimontiq Salsabilla Putri , Setiawan Fajar , Naila Ishmatun 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui evaluasi pembelajaran IPS melalui aplikasi quizizz di SD Hidayatul Ummah Surabaya. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan deskriptif. Subyek penelitian ini adalah peserta didik kelas 5 SD Hidayatul Ummah Surabaya yang berjumlah 26 siswa. Proses pengumpulan data dilakukan melalui metode wawancara, dokumentasi dan Kuisioner. Hasil penelitian menunjukkan bahwa evaluasi pembelajaran IPS Sekolah Dasar melalui aplikasi quizizz memudahkan guru serta siswa dalam evaluasi pembelajaran IPS kelas 5 Sekolah Dasar.
PENGEMBANGAN SOAL IPAS SEKOLAH DASAR BERBASIS HIGHER ORDER THINKING SKILLS
Authors: Moinewa Yohana Anjelina , Laksana Dek Ngurah Laba , Dolo Fransiskus Xaverius , Kua Maria Yuliana 
Published: November 2023

Pengembangan soal tes berbasis HOTS dirasa sangat penting dikembangkan di Sekolah Dasar untuk mengembangkan keterampilan berpikir tingat tinggi siswa. Berdasarkan hasil studi pendahuluan di Sekolah Dasar ditemukan kurangnya pengembangan soal tes yang mengembangkan keterampilan berpikir tingkat tinggi siswa. Penelitian ini bertujuan untuk mengembangkan soal tes berbasis HOTS yang dikemukakan oleh Bloom revisi C4 (menganalisis), C5 (mengevaluasi), C6 (mencipta). Penelitian dilakukan menggunakan metode DBR (Desigen-Based-Research) yang dikemukaakan oleh Reeves tahun 2007. Tahap pertama pada studi pendahuluan diperoleh data dari hasil wawancara dan studi dokumentasi. Tahap kedua dilakukan pengembangan soal HOTS sesuai dengan indikator pembelajaran pada tema zat dan perubahannya yang dilakukan menggunakan model latihan penelitian. Tahap tiga, dilakukan validasi ahli dan mengalami revisi I dan dilakukan uji coba I. Pada hasil uji coba I dilihat dari validitas, reliabilitas, terdapat 5 soal yang harus diperbaiki. Dilakuan revisi II dan dilakukan uji coba II dengan hasil semua soal valid dan reliabel. Hasil akhir pada tahap empat menunjukan bahwa produk soal berupa 10 butir soal pilihah ganda dan 5 soal essay yang dikembangkan valid, praktis, dan layak untuk digunakan.
Kata kunci : Soal tes, HOTS, model pembelajaran latihan penelitian, zat dan perubahannya.
Spectral Templates Optimal for Selecting Galaxies at z > 8 with the JWST
Authors: Larson Rebecca L. , Hutchison Taylor A. , Bagley Micaela , Finkelstein Steven L. , Yung L. Y. Aaron , Somerville Rachel S. , Hirschmann Michaela , Brammer Gabriel , Holwerda Benne W. , Papovich Casey , Morales Alexa M. , Wilkins Stephen M. 
Published: November 2023

Abstract
The selection of high-redshift galaxies often involves spectral energy distribution (SED) fitting to photometric data, an expectation for contamination levels, and measurement of sample completeness—all vetted through comparison to spectroscopic redshift measurements of a sub-sample. The first JWST data are now being taken over several extragalactic fields to different depths and across various areas, which will be ideal for the discovery and classification of galaxies out to distances previously uncharted. As spectroscopic redshift measurements for sources in this epoch will not be initially available to compare with the first photometric measurements of z > 8 galaxies, robust photometric redshifts are of the utmost importance. Galaxies at z > 8 are expected to have bluer rest-frame ultraviolet (UV) colors than typically used model SED templates, which could lead to catastrophic photometric redshift failures. We use a combination of BPASS and Cloudy models to create a supporting set of templates that match the predicted rest-UV colors of z > 8 simulated galaxies. We test these new templates by fitting simulated galaxies in a mock catalog, Yung et al., which mimic expected field depths and areas of the JWST Cosmic Evolution Early Release Science Survey (m
5σ
∼ 28.6 over ∼100 arcmin2). We use EAZY to highlight the improvements in redshift recovery with the inclusion of our new template set and suggest criteria for selecting galaxies at 8 < z < 10 with the JWST, providing an important test case for observers venturing into this new era of astronomy.
Anisotropic Star Clusters around Recoiling Supermassive Black Holes
Authors: Akiba Tatsuya , Madigan Ann-Marie 
Published: November 2023

Abstract
Gravitational-wave recoil kicks from merging supermassive black hole binaries can have a profound effect on the surrounding stellar population. In this work, we study the dynamic and kinematic properties of nuclear star clusters following a recoil kick. We show that these postkick structures present unique signatures that can provide key insight to observational searches for recoiling supermassive black holes. In our previous paper, we showed that an in-plane recoil kick turns a circular disk into a lopsided, eccentric disk such as the one we observe in the Andromeda nucleus. Building on this work, here we explore many recoil kick angles as well as initial stellar configurations. For a circular disk of stars, an in-plane kick causes strong apsidal alignment with a significant fraction of the disk becoming retrograde at large radii. If the initial orbits are highly eccentric, an in-plane kick forms a bar-like structure made up of two antialigned lopsided disks. An out-of-plane kick causes clustering in the argument of periapsis, ω, regardless of the initial eccentricity distribution. Initially, isotropic configurations form anisotropies in the form of a torus of eccentric orbits oriented perpendicular to the recoil kick. Postkick surface density and velocity maps are presented in each case to highlight the distinct, observable structures of these systems.
Neutron Star Kicks and Implications for Their Rotation at Birth
Authors: Fragione Giacomo , Loeb Abraham 
Published: November 2023

Abstract
Neutron stars are born out of core-collapse supernovae, and they are imparted natal kicks at birth as a consequence of asymmetric ejection of matter and possibly neutrinos. Unless the force resulting from the kicks is exerted exactly at their center, it will also cause the neutron star to rotate. In this paper, we discuss the possibility that neutron stars may receive off-center natal kicks at birth, which imprint a natal rotation. In this scenario, the observed pulsar spin and transverse velocity in the Galaxy are expected to correlate. We develop a model of the natal rotation imparted to neutron stars and constrain it by the observed population of pulsars in our Galaxy. When considering a single-kick position parameter, we find that the location of the off-center kick is

R

kick

=

2.03

−
1.69

+
3.74

km at 90% confidence, and is robust when considering pulsars with different observed periods, transverse velocities, and ages. Nonetheless, the model encounters challenges in effectively fitting the data, particularly at small transverse velocities, prompting the exploration of alternative models that include more complex physics. Our framework could be used as a guide for core-collapse simulations of massive stars.
The Discovery of 63 Giant Radio Galaxies in the FIRST Survey
Authors: Ramdhanie Soren , Gordon Yjan A. , Andernach Heinz , Hooper Eric J. , Sampson Brianna 
Published: November 2023

Abstract
Giant Radio Galaxies (GRGs) are Active Galactic Nuclei with radio emission that extends over projected sizes >0.7  Mpc. The large angular sizes associated with GRGs complicate their identification in radio survey images using traditional source finders. In this Note, we use DRAGNhunter, an algorithm designed to find double-lobed radio galaxies, to search for GRGs in the Faint Images of the Radio Sky at Twenty cm survey. Radio and optical images of identified candidates are visually inspected to confirm their authenticity, resulting in the discovery of 63 previously unreported GRGs.
Biothérapies : opportunités et accessibilité
Authors: Fischer Alain 
Published: November 2023

Les progrès de la recherche biomédicale conduisent à l’émergence de nombre de médicaments innovants issus des biothérapies : protéines recombinantes, anticorps monoclonaux, thérapie génique et thérapie fondée sur les ARN. Ces biothérapies sont utilisées comme traitement de cancers, de maladies inflammatoires, de maladies génétiques et en vaccination. Les perspectives sont encore plus prometteuses. Toutefois, ces médicaments innovants sont commercialisés à des prix très élevés qui mettent en péril leur accessibilité future pour l’ensemble de la population. De nouvelles règles d’établissement des prix doivent être élaborées à l’échelle internationale pour préserver l’équilibre entre intérêt privé et bien public. L’hypothèse de la production de centaines de ces médicaments par des entités sans but lucratif doit être également envisagée.
Andrographis paniculata extract versus placebo in the treatment of COVID-19: a double-blinded randomized control trial
Authors: Kanokkangsadal Puritat , Mingmalairak Chatchai , Mukkasombat Nichamon , Kuropakornpong Pranporn , Worawattananutai Patsorn , Khawcharoenporn Thana , Sakpakdeejaroen Intouch , Davies Neal M. , Itharat Arunporn 
Published: November 2023

Background and purpose:

Andrographis paniculata (Burm.f.) Nees has been recommended to relieve symptoms and decrease the severity of COVID-19. The clinical study aimed to investigate the efficacy and safety of A. paniculata ethanolic extract (APE).

Experimental approach:
The efficacy and safety of APE in asymptomatic or mildly symptomatic COVID-19 patients compared with placebo were investigated through a prospective, double-blind randomized control trial. Patients received APE containing 60 mg of andrographolide, three times a day for five days. WHO progression scale, COVID-19 symptoms, and global assessment evaluated the efficacy and adverse events, liver and renal functions were monitored for safety.

Findings/Results:
165 patients completed the study (83 patients in the APE group and 82 patients in the placebo group). The highest WHO progression scale was 4 and COVID-19 symptoms were significantly relieved on the last day of intervention in both groups, with no significant difference between groups. APE significantly relieved headache symptoms on day 1 and olfactory loss symptoms on day 2 compared to placebo. The global assessment showed that 80.7% of patients had total recovery after 5-day treatment with APE. Mild diarrhea was the most common side effect with a high dose that resolved within a few days. No hepatic or renal toxicity was associated with treatment.

Conclusion and implications:
APE at 180 mg/day for 5 days did not reduce COVID-19 progression in asymptomatic or mildly afflicted COVID-19 patients, however, it shortened the symptoms of olfactory loss with no adverse effects over 5 days of use.
The reinstatement of the expression phase of morphine-induced conditioned place preference in male Wistar rats under ventral tegmental area stimulation and brief inactivation
Authors: Pour Mozhgan Ghobadi , Alaei Hojjatollah 
Published: November 2023

Background and purpose:
Previous research has found that the electrical stimulation of the ventral tegmental area (VTA) is involved in drug-dependent behaviors and plays a role in reward-seeking. However, the mechanisms remain unknown, especially the effect of electrical stimulation on this area. Therefore, this study aimed to investigate how the electrical stimulation and the temporary inactivation of VTA affect the morphine- dependent behavior in male rats.

Experimental approach:
The adult Wistar male rats were anesthetized with ketamine and xylazine. The stimulation electrode (unilaterally) and the microinjection cannula (bilaterally) were implanted into the VTA, stereotaxically. Then, the rats underwent three-day of repeated conditioning with subcutaneous morphine (0.5 or 5 mg/kg) injections, in the conditioned place preference apparatus, followed by four-day forced abstinence, which altered their conditioning response to a morphine (0.5 mg/kg) priming dose on the ninth day. On that day, rats were given high- or low-intensity electrical stimulation or reversible inactivation with lidocaine (0.5 pL/site) in the VTA.

Findings/Results:
Results showed that the electrical stimulation of the VTA with the high intensity (150 μA/rat), had a minimal effect on the expression of morphine-induced place conditioning in rats treated with a high dose (5 mg/kg) of morphine. However, the reversible inactivation of the VTA with lidocaine greatly increased place preference in rats treated with a low dose (0.5 mg/kg) of morphine. Additionally, the reinstatement of 0.5 mg/kg morphine-treated rats was observed after lidocaine infusion into the VTA.

Conclusion and implications:
These results suggest that VTA electrical stimulation suppresses neuronal activation, but the priming dose causes reinstatement. The VTA may be a potential target for deep brain stimulation-based treatment of intractable disorders induced by substance abuse.
Perception of the Health-care Providers toward Telemedicine Practice: A Cross-sectional Study from Karnataka, India
Authors: Davalagi Shubha Bakkappa , Kasturi Eshwar S. , Nayak P Vaman , Ghose Anisha 
Published: November 2023

Introduction:
The major advantages of telemedicine can be saving time, cost, and effort, especially for rural patients, during challenging times such as COVID for obtaining consultation and treatment. Telemedicine, if properly implemented, can reduce gaps and strengthen the health-care delivery system in India.

Objective:
The objective of the study was to assess the perception and practice of health-care providers toward telemedicine.

Methodology:
We conducted a cross-sectional study among 141 health-care providers who ever practiced telemedicine consultation. Utilizing online Google Forms, we used snowball sampling. Four sections made up the pretested study questionnaire: demographic information, perceptions, and practices. Statistical Package for the Social Sciences (SPSS) version 21 was used for data analysis.

Results:
Among them, majority were aged between 35 and 44 years (49.6%), males (56%), had M.D./M.S. degree (57.4%), postgraduates (33.3%), worked in private sector (56.7%), and were from clinical specialty (80.8%) We had majority health-care workers who used telemedicine application for the first time after COVID (80.1%), used only mobile (82.2%), used only one application (83.6%), and gave 5–10 consultations per day (57.4%). Most of our study participants feel teleconsultation takes less time (61.7%), reduces waiting list at medical center (92.9%), has better communication (83.6%), gives better aid during emergency (53.9%), and saves money on transportation (97.1%).

Conclusion:
In this study, we could conclude that most participants started practicing telemedicine post-COVID. Health-care professionals still feel challenging to provide effective patient counseling through telemedicine; moreover, they are benefitted from telemedicine practice.