bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced biomaterial agent from chitosan/poloxamer 407-based thermosensitive hydrogen containing biosynthesized silver nanoparticles using Eucalyptus camaldulensis leaf extract
Authors: Wunnoo Suttiwan , Lorenzo-Leal Ana C. , Voravuthikunchai Supayang P. , Bach Horacio 
Published: October 2023

Context
The emergence of multidrug-resistant (MDR) pathogens poses a significant challenge for global public health systems, increasing hospital morbidity and mortality and prolonged hospitalization.

Objective
We evaluated the antimicrobial activity of a thermosensitive hydrogel containing bio-synthesized silver nanoparticles (bio-AgNPs) based on chitosan/poloxamer 407 using a leaf extract of Eucalyptus calmadulensis.

Results
The thermosensitive hydrogel was prepared by a cold method after mixing the ingredients and left at 4°C overnight to ensure the complete solubilization of poloxamer 407. The stability of the hydrogel formulation was evaluated at room temperature for 3 months, and the absorption peak (420 nm) of the NPs remained unchanged. The hydrogel formulation demonstrated rapid gelation under physiological conditions, excellent water retention (85%), and broad-spectrum antimicrobial activity against MDR clinical isolates and ATCC strains. In this regard, minimum inhibitory concentration and minimum microbial concentration values of the bio-AgNPs ranged from 2–8 μg/mL to 8−128 μg/mL, respectively. Formulation at concentrations <64 μg/mL showed no cytotoxic effect on human-derived macrophages (THP-1 cells) with no induction of inflammation.

Conclusions
The formulated hydrogel could be used in biomedical applications as it possesses a broad antimicrobial spectrum and anti-inflammatory properties without toxic effects on human cells.
Assessment of global histone acetylation in pediatric and adolescent obesity: Correlations with SIRT1 expression and metabolic-inflammatory profiles
Authors: Taghizadeh Nima , Mohammadi Soha , yousefi Zeynab , Golpour Pegah , Taheri Alemeh , Maleki Mohammad Hasan , Nourbakhsh Mitra , Nourbakhsh Mona , Azar Maryam Razzaghy 
Published: October 2023

Background
Epigenetic modifications, particularly histone acetylation-deacetylation and its related enzymes, such as sirtuin 1 (SIRT1) deacetylase, may have substantial roles in the pathogenesis of obesity and its associated health issues. This study aimed to evaluate global histone acetylation status and SIRT1 gene expression in children and adolescents with obesity and their association with metabolic and anthropometric parameters.

Methods
This study included 60 children and adolescents, 30 with obesity and 30 normal-weight. The evaluation consisted of the analysis of global histone acetylation levels and the expression of the SIRT1 gene in peripheral blood mononuclear cells, by specific antibody and real-time PCR, respectively. Additionally, insulin, fasting plasma glucose, lipid profile and tumor necrosis factor α (TNF-α) levels were measured. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Metabolic syndrome was determined based on the diagnostic criteria established by IDF.

Results
Individuals with obesity, particularly those with insulin resistance, had significantly higher histone acetylation levels compared to control group. Histone acetylation was positively correlated with obesity indices, TNF-α, insulin, and HOMA-IR. Additionally, a significant decrease in SIRT1 gene expression was found among obese individuals, which was negatively correlated with the histone acetylation level. Furthermore, SIRT1 expression levels showed a negative correlation with various anthropometric and metabolic parameters.

Conclusion
Histone acetylation was enhanced in children and adolescents with obesity, potentially resulting from down-regulation of SIRT1, and could play a role in the obesity-associated metabolic abnormalities and insulin resistance. Targeting global histone acetylation modulation might be considered as an epigenetic approach for early obesity management.
Beauvoir or Butler? Comparing ‘Becoming a Woman’ with ‘Performing Gender’ Through the Life Course
Authors: Pickard Susan 
Published: October 2023

AbstractJudith Butler claims to have based her theory of gender performance on Simone de Beauvoir’s path-breaking idea that one is not born, but rather becomes, a woman. However, Butler’s interpretation of Beauvoir’s work departs considerably from Beauvoir’s own expressed view which is that women are shaped by an interplay of femininity (construed by cultural and structural norms) and sexed bodies and that the concept of woman is a mutable one that can accommodate increasing degrees of freedom. In this paper I explore Beauvoir’s theories further, showing how they depart from Butler’s interpretations of them and in the process exploring the contribution that Beauvoir and Butler respectively make towards understanding ongoing gender inequality. Finally, I compare and contrast the role of temporality and the life course in ‘becoming a woman’ and in performing gender respectively, focusing on the figure of the post-menopausal woman in particular.
Solar driven desalination system for power and desalination water production by concentrated PVT and MED system
Authors: Zhang Xiaochuan 
Published: October 2023

Abstract
In this paper, a thermodynamic study of the combination of Concentrated Photovoltaic Thermal (CPVT) and Multi Effect Desalination (MED) system was conducted. CPVT produces electricity, and the heat produced in CPVT is used for the MED system. Engineering Equation Software (EES) was utilized to simulate this system. The effect of CPVT parameters (area, concentration ratio, and average solar radiation) and MED parameters (effect number and temperature of heating steam) were investigated on the produced heat, produced power, exergy destruction, total mass flow rate (FR) of desalinated water, total FR of feed water, heating steam FR and total brine FR. The range of changes for CPVT surface, concentration ratio, and average solar radiation was considered from 2000 m2 to 20000 m2, from 5 to 15 and from 400 W/m2 to 1100 W/m2, respectively. Based on obtained results, as the surface area of the solar panel, the ratio of concentration, and average solar radiation increase, the heat produced increases. Transferring this heat to the MED unit increases the total FR of desalinated water. But it has no significant effect on the Gain ratio (GOR). As the surface area of the solar panel increases from 10000 m2 to 12000 m2, the average radiation intensity increases from 800 W/m2 to 1000 W/m2, and the concentration ratio increases from 10 to 12 in effect the number of 4 and steam temperature of 70 °C, the total mass FR of desalinated water increases by 29 %, 23 %, and 20 %, respectively.
Phytofabrication, characterization, and evaluation of novel bioinspired selenium–iron (Se–Fe) nanocomposites using Allium sativum extract for bio-potential applications
Authors: Sultana Tahira , Malik Khafsa , Raja Naveed Iqbal , Sohail  , Hameed Asma , Ali Amir , Mashwani Zia-ur-Rehman , Baloch Muhammad Yousuf Jat , Alrefaei Abdulwahed Fahad 
Published: October 2023

Abstract
Green nano-chemistry is an advanced research route covering eco-friendly fabrication approaches for synthesizing bimetallic nanocomposites (NCs) to enhance their therapeutic properties. The current study aims to phytofabrication, characterization, and bio-potential evaluation of novel selenium–iron (Se–Fe) NCs by utilizing garlic extract. The morphological and physicochemical features of Se–Fe NCs were evaluated by UV–visible spectroscopy, scanning electron microscopy, energy-dispersive X-ray, Fourier transform infrared, X-ray diffraction, and Zeta potential analysis. The findings showed that garlic cloves extract was a promising capping and reducing agent for the formulation of the NC. To explore the antioxidant potential of a bioinspired Se–Fe NC, 2,2-diphenyl-1-picrylhydrazyl and reducing power assays were performed. Furthermore, antioxidant efficacy was confirmed through antimicrobial activities against clinical pathogens. Phytosynthesized Se–Fe NCs (25, 50, 75, and 100 ppm) showed a dose-dependent response. Higher concentrations of Se–Fe NCs impose a more potent antioxidant and antimicrobial potential. The astonishing findings suggest that phytochemicals in Allium sativum extract are useful reducing agents in the formulation of well-defined Se–Fe NCs, and such NCs could act as competitive inhibitors against pathogens. To the extent of our understanding, Se–Fe NC is the first time synthesized and demonstrates the distinctiveness of green chemistry and will give multifunctional applications in nano-biotechnology.
Reconfigurable polarization processor based on coherent four-port micro-ring resonator
Authors: Yi Dan , Luan Jiapeng , Wang Yi , Tsang Hon Ki 
Published: October 2023

Abstract
Polarization processors with versatile functionalities are needed in optical systems, which use or manipulate polarized light. In this paper, we propose and realize an integrated polarization processor based on a coherent 4-port micro-ring resonator. The arbitrary unknown polarization state is input to the polarization processor via a 2-dimensional grating coupler (2DGC), which serves as a polarization beam splitter. The coherent 4-port micro-ring resonator (MRR) operates as a unitary processor and is formed by one crossbar micro-ring resonator and two thermally tunable phase shifters, one of which tunes the micro-ring while the other tunes the coherent interference between the two inputs from the 2DGC. The 4-port system can be used to control the input polarization states that appear at the two output ports and, therefore, can be used to implement a multi-function polarization processor, including polarization descrambler, polarization switch, polarizers, and polarization analyzer (both division of space (DOS) and division of time (DOT)). In this paper, we experimentally demonstrate the use of coherent 4-port MRR for polarization mode switching and for polarization mode unscrambling. The polarization unscrambler was capable of separating two polarization-multiplexed 40 GHz data lanes from the input fiber with crosstalk levels below −21 dB and is suitable for use in the receiver for polarization-multiplexed direct-detection optical communications systems. The same photonic circuit may be used as a polarization analyzer, either as a DOS polarization analyzer or a DOT polarization analyzer. The DOS polarization analyzer measured the polarization with measured deviation of the orientation angle (2ψ) varying from −0.5° to 1.3°and deviation of ellipticity angle (2χ) varying from −0.98° to 7.27°. The DOT polarization analyzer measured the polarization with a deviation of the orientation angle (2ψ) that varied from −2.93° to 3.49° and deviation of ellipticity angle (2χ) that varied from −3.5° to 3.05°.
Synthesis and crystal structure of (3E,5S,10S,13S,14S,17Z)-17-ethylidene-10,13-dimethylhexadecahydro-3H-cyclopenta[α]phenanthren-3-one O-(methacryloyl) oxime, C50H74N2O4
Authors: Wei Peng , Zhao Jin-Feng , Zou Juan , Ye Jiang-Hai , He Kang , Xu Hong 
Published: October 2023

Abstract
C50H74N2O4, orthorhombic, P1 (no. 1), a = 7.3320(3) Å, b = 11.8132(4) Å, c = 13.1604(5) Å, α = 99.1910(10)°, β = 95.039(1)°, γ = 95.8560(10)°, V = 1113.06(7) Å3, Z = 1, Rgt
(F) = 0.0662, wRref
(F
2) = 0.1655, T = 273(2) K.
Trans-Sequentielle Analyse und Kommunikativ-Konstruktivistische Videographi
Authors: Tuma René 
Published: October 2023

ZusammenfassungIn diesem Beitrag wird diskutiert, inwieweit die Forschungsprogramme der Trans-Sequentiellen Analyse und der kommunikativkonstruktivistisch fundierten Videographie anschlussfähig sind und wo sie sich ergänzen. Am Beispiel zweier Studien des Autors zur vernakularen Videoanalyse und zu Straßengewalt werden Gemeinsamkeiten und Anknüpfungspunkte herausgearbeitet und die Produktivität der Konzepte der kommunikativen Formen und Gattungen, der interaktiven Trajektorien, des Arbeitsbogens und der Unterscheidung von Kontext und Kontextur aufgezeigt. Sowohl die Trans-Sequentielle Analyse als auch die Videographie stammen aus der interpretativen Sozialforschung und überschneiden sich in ihrem Bezug auf verwandte, aber nicht identische theoretische Grundlagen. Für die Trans-Sequentielle Analyse liegt der Bezug vor allem in der Ethnomethodologie und der Actor-Network Theory. Die im kommunikativen Konstruktivismus verortete Videographie greift hier ebenfalls Momente auf, betont aber stärker die analytische Einbeziehung von Subjekten, Wissen und Institutionen.
Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice
Authors: Andraini Trinovita , Moulédous Lionel , Petsophonsakul Petnoi , Florian Cédrick , Gauzin Sébastien , Botella-Daloyau Marlène , Arrázola Macarena , Nikolla Kamela , Philip Adam , Leydier Alice , Marque Manon , Arnauné-Pelloquin Laetitia , Belenguer Pascale , Rampon Claire , Miquel Marie-Christine 
Published: October 2023

AbstractMitochondria are integrative hubs central to cellular adaptive pathways. Such pathways are critical in highly differentiated postmitotic neurons, the plasticity of which sustains brain function. Consequently, defects in mitochondria and in their dynamics appear instrumental in neurodegenerative diseases and may also participate in cognitive impairments. To directly test this hypothesis, we analyzed cognitive performances in a mouse mitochondria-based disease model, because of haploinsufficiency in the mitochondrial optic atrophy type 1 (OPA1) protein involved in mitochondrial dynamics. In males, we evaluated adult hippocampal neurogenesis parameters using immunohistochemistry. We performed a battery of tests to assess basal behavioral characteristics and cognitive performances, and tested putative treatments. While in dominant optic atrophy (DOA) mouse models, the known main symptoms are late onset visual deficits, we discovered early impairments in hippocampus-dependent spatial memory attributable to defects in adult neurogenesis. Moreover, less connected adult-born hippocampal neurons showed a decrease in mitochondrial content. Remarkably, voluntary exercise or pharmacological treatment targeting mitochondrial dynamics restored spatial memory in DOA mice. Altogether, our study identifies a crucial role for OPA1-dependent mitochondrial functions in adult neurogenesis, and thus in hippocampal-dependent cognitive functions. More generally, our findings show that adult neurogenesis is highly sensitive to mild mitochondrial defects, generating impairments in spatial memory that can be detected at an early stage and counterbalanced by physical exercise and pharmacological targeting of mitochondrial dynamics. Thus, amplification of mitochondrial function at an early stage appears beneficial for late-onset neurodegenerative diseases.
Distributed Coding of Evidence Accumulation across the Mouse Brain Using Microcircuits with a Diversity of Timescales
Authors: Imani Elaheh , Radkani Setayesh , Hashemi Alireza , Harati Ahad , Pourreza Hamidreza , Moazami Goudarzi Morteza 
Published: October 2023

AbstractThe gradual accumulation of noisy evidence for or against options is the main step in the perceptual decision-making process. Using brain-wide electrophysiological recording in mice (Steinmetz et al., 2019), we examined neural correlates of evidence accumulation across brain areas. We demonstrated that the neurons with drift-diffusion model (DDM)-like firing rate activity (i.e., evidence-sensitive ramping firing rate) were distributed across the brain. Exploring the underlying neural mechanism of evidence accumulation for the DDM-like neurons revealed different accumulation mechanisms (i.e., single and race) both within and across the brain areas. Our findings support the hypothesis that evidence accumulation is happening through multiple integration mechanisms in the brain. We further explored the timescale of the integration process in the single and race accumulator models. The results demonstrated that the accumulator microcircuits within each brain area had distinct properties in terms of their integration timescale, which were organized hierarchically across the brain. These findings support the existence of evidence accumulation over multiple timescales. Besides the variability of integration timescale across the brain, a heterogeneity of timescales was observed within each brain area as well. We demonstrated that this variability reflected the diversity of microcircuit parameters, such that accumulators with longer integration timescales had higher recurrent excitation strength.
ENERGY EFFICIENCY RESEARCH OF LPWAN TECHNOLOGIES
Authors: Lykov Y. V. , Gorelov D. Y. , Lykova A. A. , Savenko S. O. 
Published: October 2023

Context. The emergence of the Internet of Things (IoT) has led to the development of various low-power wide area network (LPWAN) technologies that are designed to provide transmission of small data packets over long distances with minimal energy consumption. The two most well-known LPWAN technologies are LoRaWAN and Sigfox. This study aims to compare the energy efficiency of these two technologies to determine their suitability for use in autonomous solutions.
Objective. The objective of this study is to compare the energy efficiency of LoRaWAN and Sigfox technologies for IoT devices. The comparison will help determine which technology is better for autonomous solutions when devices need to operate for extended periods of time without frequent battery replacements.
Method. In this work, taking into account the specifications of the investigated radio technologies, mathematical modeling of the time of data transmission or reception is used depending on the payload, and information on the power supply current is taken from official datasheets for the components of the investigated devices.
Results. The results of the study show that both LoRaWAN and Sigfox are energy-saving technologies, but LoRaWAN is generally more energy-efficient than Sigfox. In addition, LoRaWAN has adaptive modes and significantly more manual settings, which in some cases further reduces the energy per bit of data compared to Sigfox.
Conclusions. LoRaWAN is the best choice for autonomous solutions where energy efficiency is crucial. This study provides valuable information for designers and developers of IoT devices, allowing them to make informed decisions when choosing LPWAN technologies for their autonomous solutions.
Incidence and clinical decision making for the Wada test over one decade: 1997‐2007
Authors: Das Rohit R. , Alexopoulos Andreas V. , Loddenkemper Tobias 
Published: October 2023

ABSTRACTPurposeThe objective of this study was to review the percentage of Wada tests performed on patients with intractable temporal lobe epilepsy undergoing surgery at a single epilepsy centre over the last decade, and to identify clinical features which are more likely associated with decision making in favour of Wada testing.MethodsWe retrospectively reviewed all temporal lobe resections performed between 1997 and 2007 at the Cleveland Clinic Epilepsy Center.ResultsA total of 410 Wada tests were conducted on 777 patients undergoing temporal lobectomy (TL). Left temporal resection was performed in 55% of cases. The most frequent pathological diagnoses were hippocampal sclerosis (42%) and non‐specific gliosis (26%). Overall, Wada test frequency in patients undergoing presurgical evaluation decreased over time. In 1997, 47 of 58 (81%) TL patients underwent Wada testing compared to 11 of 76 (14.4%) in 2007. Patients with left temporal lobe epilepsy, and/or those referred for subdural electrode placement, were significantly more likely to undergo Wada testing. The most common types of surgery were anteromedial temporal resection with removal of mesial structures (59%) and temporal resection without mesial structure removal (32%). Patients with left temporal epilepsy and Wada testing were significantly more likely to undergo resection of mesial cortex.DiscussionWada testing has declined over the last decade in this single centre study. Patients with left, likely dominant, temporal lobe epilepsy and those with subdural evaluations were more likely to undergo Wada testing. We speculate that the emergence of alternative noninvasive language lateralization techniques, along with concerns about the reliability of results and awareness of complication risks, are major reasons for the decline.
Statistical analysis of transcallosal propagation of spikes arising from the mesial frontal area
Authors: Umeoka Shuichi C. , Lüders Hans O. , Sangani Masoud Abed , Turnbull John P. 
Published: October 2023

ABSTRACTObjectiveTo study the connections between bilateral mesial frontal (MF) regions.MethodsWe evaluated synchrony of spikes, recorded by subdural electrodes, arising from bilateral MF regions using cross correlation in MF epilepsy. A seven‐year‐old boy with intractable daily bilateral asymmetric tonic seizures and a normal MRI was investigated. To confirm the lateralization of epileptogenicity, subdural electrodes were implanted bilaterally. Only spikes of an amplitude of 400 μV or more were analyzed.ResultsOf 92.4% (194/210) of the left MF spikes recorded for 30 minutes, an approximately synchronous spike was also detected in the right MF region. Cross correlation analysis demonstrated that for 88.7% of the bilateral MF spikes (172/194, 88.7%) the left MF spike led the contralateral spikes with relative fixed peak‐to‐peak intervals (18.9 ± 11.1 ms) and high cross correlation values (0.81 ± 0.10). An estimated conduction velocity of 7.2 ± 9.8 m/sec was calculated (assuming no synaptic delay). After a second period of more extended invasive EEG monitoring, a left partial frontal lobectomy was performed and the patient immediately had a few brief seizures before remaining seizure‐free for a follow‐up period of 14 months.ConclusionWe conclude that the propagation of spikes between bilateral MF regions most likely occurs mainly through myelinated callosal fibres. In addition, this cross correlation method showed that the left MF spikes, most of the time, preceded the right MF spikes suggesting that the epileptogenic zone was localized in the left MF region.
Correlation between child and parental perceptions of health‐related quality of life in epilepsy using the PedsQL.v4.0 measurement model
Authors: Haneef Zulfi , Grant Mitzie L. , Valencia Ignacio , Hobdell Elizabeth F. , Kothare Sanjeev V. , Legido Agustin , Khurana Divya 
Published: October 2023

ABSTRACTHealth‐related quality‐of‐life measures in childhood epilepsy are typically limited to a particular functional domain, specific age group, parent proxy‐report, or child self‐report. Generic health‐related quality‐of‐life instruments in paediatric epilepsy comparing child self‐reports with simultaneous parent proxy‐reports have not been previously investigated. A previously validated generic questionnaire, the Pediatric Quality of Life version 4 (PedsQL.v4.0), was used to prospectively assess parental and child perceptions of health‐related quality of life in 100 children with epilepsy. The correlation between child and parental health‐related quality‐of‐life perceptions across all domains was excellent (p < 0.001) and both were significantly lower than those for healthy controls (p < 0.001). Parents' perceptions of their children's health‐related quality of life were lower than those for other chronic illnesses (p < 0.001), especially for refractory epilepsy. The presence of neurological or psychiatric comorbidities also had an adverse impact on health‐related quality of life. The PedsQL.v4.0 measures health‐related quality of life from both the parent's and child's perspective. Ease of use makes this instrument attractive for routine clinical use.