bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-35: New Target for Immunotherapy Targeting the Tumor Microenvironment
Authors: Yi Pengcheng , Yu Wenjun , Xiong Yanhong , Dong Yao , Huang Qiang , Lin Yue , Du Yunfei , Hua Fuzhou 
Published: November 2023

Abstract
Interleukin 35(IL-35) is a newly discovered inhibitory cytokine of the IL12 family. More recently, IL-35 was found to be increased in the tumor microenvironment (TME) and peripheral blood of many patients with cancer, indicating that it plays an important role in the TME. Tumors secrete cytokines that recruit myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Treg) into the TME to promote malignant progression, which is a great challenge for cancer treatment. Radiotherapy causes serious adverse effects, and tumor resistance to immune checkpoint inhibitors is still an unsolved challenge. Thus, new cancer therapy approaches are urgently needed. Numerous studies have shown that IL-35 can recruit immunosuppressive cells to enable tumor immune escape by promoting the conversion of immune cells into a tumor growth–promoting phenotype as well as facilitating tumor angiogenesis. IL-35-neutralizing antibodies were found to boost the chemotherapeutic effect of gemcitabine and considerably reduce the microvascular density of pancreatic cancer in mice. Therefore, targeting IL-35 in the TME provides a promising cancer treatment target. In addition, IL-35 may be used as an independent prognostic factor for some tumors in the near future. This review intends to reveal the interplay of IL-35 with immune cells in the TME, which may provide new options for the treatment of cancer.
Is there a comic book industry?
Authors: Woo Benjamin 
Published: November 2023

The “American comic book industry” is not American, its true product is not comic books, and it may not even be an industry. This article uses a geospatial map of comic book and graphic novel publishers active in the US market as well as sales estimates derived from both the direct market of specialty comic book retailers and trade book stores to question inherited “mental maps” of comic book publishing, such as the divide between “mainstream” and “alternative”/“independent” publishing. Adopting a relational approach, it suggests that a sociology of comics publishing – and of the cultural industries more generally – must be cautious of taking on board un-sociological concepts like “industry.”
Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study
Authors: Tang Gilbert H.L. , Spencer Julianne , Rogers Toby , Grubb Kendra J. , Gleason Patrick , Gada Hemal , Mahoney Paul , Dauerman Harold L. , Forrest John K. , Reardon Michael J. , Blanke Philipp , Leipsic Jonathon A. , Abdel-Wahab Mohamed , Attizzani Guilherme F. , Puri Rishi , Caskey Michael , Chung Christine J. , Chen Ying-Hwa , Dudek Dariusz , Allen Keith B. , Chhatriwalla Adnan K. , Htun Wah Wah , Blackman Daniel J. , Tarantini Giuseppe , Zhingre Sanchez Jorge , Schwartz Greta , Popma Jeffrey J. , Sathananthan Janarthanan 
Published: November 2023

BACKGROUND:
Coronary accessibility following redo–transcatheter aortic valve replacement (redo-TAVR) is increasingly important, particularly in younger low-risk patients. This study aimed to predict coronary accessibility after simulated Sapien-3 balloon-expandable valve implantation within an Evolut supra-annular, self-expanding valve using pre-TAVR computed tomography (CT) imaging.

METHODS:
A total of 219 pre-TAVR CT scans from the Evolut Low-Risk CT substudy were analyzed. Virtual Evolut and Sapien-3 valves were sized using CT-based diameters. Two initial Evolut implant depths were analyzed, 3 and 5 mm. Coronary accessibility was evaluated for 2 Sapien-3 in Evolut implant positions: Sapien-3 outflow at Evolut node 4 and Evolut node 5.

RESULTS:

With a 3-mm initial Evolut implant depth, suitable coronary access was predicted in 84% of patients with the Sapien-3 outflow at Evolut node 4, and in 31% of cases with the Sapien-3 outflow at Evolut node 5 (
P
<0.001). Coronary accessibility improved with a 5-mm Evolut implant depth: 97% at node 4 and 65% at node 5 (
P
<0.001). When comparing 3- to 5-mm Evolut implant depth, sinus sequestration was the lowest with Sapien-3 outflow at Evolut node 4 (13% versus 2%;
P
<0.001), and the highest at Evolut node 5 (61% versus 32%;
P
<0.001).

CONCLUSIONS:
Coronary accessibility after Sapien-3 in Evolut redo-TAVR relates to the initial Evolut implant depth, the Sapien-3 outflow position within the Evolut, and the native annular anatomy. This CT-based quantitative analysis may provide useful information to inform and refine individualized preprocedural CT planning of the initial TAVR and guide lifetime management for future coronary access after redo-TAVR.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02701283.
Redo Transcatheter Aortic Valve Implantation in the Lotus Mechanically Expanded Transcatheter Heart Valve: Bench-Top Analysis, Clinical Experience, and Procedural Guidance
Authors: Alfadhel Mesfer , Frawley Chris , Sathananthan Janarthanan , de Backer Ole , Abdel-Wahab Mohamed , Abdelhafez Ahmed , Van Mieghem Nicolas M. , van den Dorpel Mark , Arunothayaraj Sandeep , Hildick-Smith David , Blackman Daniel J. 
Published: November 2023

BACKGROUND:
Redo transcatheter aortic valve implantation (TAVI) is increasing as patients outlive their transcatheter heart valves (THVs) and present with bioprosthetic valve failure. The Lotus mechanically expanded THV has unique design characteristics, which have specific implications for Redo TAVI.

METHODS:
The design features of the Lotus valve and their relevance to Redo TAVI were reviewed. Bench-top analysis of Redo TAVI was performed using different contemporary THVs. Procedural and outcome data were obtained from 10 patients who had undergone Redo TAVI for Lotus bioprosthetic valve failure in 5 centers. Recommendations for performing Redo TAVI in Lotus are made, based on these findings.

RESULTS:
The Lotus leaflets extend from the frame inflow, with a Neoskirt of only 13 mm, hence a low risk of coronary obstruction during Redo TAVI. The Lotus frame posts prevent full apposition of the Redo prosthesis in the upper part of the frame, while implantation of the Redo THV above the Lotus inflow leads to inadequate apposition of the Lotus leaflets. Inflow-to-inflow positioning is therefore recommended for effective sealing and leaflet pinning. The Lotus locking mechanism prevents overexpansion of the frame, limiting Redo THV oversizing. Redo TAVI was favorable with SAPIEN 3, Evolut, and Navitor THVs on bench-top analysis but not with ACURATE Neo 2 due to the upper crowns and short stent preventing inflow-to-inflow deployment. Case review demonstrated satisfactory outcomes in 10 patients treated with Evolut (n=6), SAPIEN 3 (n=3), and Portico (n=1) valves, with no mortality, major morbidity, or coronary obstruction. Three patients had residual mean gradient ≥20 mm Hg, including 2 of 3 SAPIEN cases. Guidance on procedural planning, valve choice, sizing, and positioning is provided.

CONCLUSIONS:
Redo TAVI in Lotus requires an understanding of unique design characteristics, and adherence to key procedural recommendations, but can be safely and effectively performed with most contemporary valve types.
The Missing Piece: A Population Health Perspective to Address the
U.S. Mental Health Crisis
Authors: Sampson Laura , Kubzansky Laura D. , Koenen Karestan C. 
Published: November 2023

Abstract
The COVID-19 pandemic has enhanced our focus on mental health. Concerns about the high levels of mental disorders in the United States are not new, with rising trends-particularly among youth-observed prior to the pandemic. However, the pandemic may have exacerbated and accelerated these trends. The silver lining is that we can leverage this moment to reevaluate and reimagine not only how we treat mental health problems, but also how we promote emotional well-being throughout the life course. We argue that scholars, policymakers, and practitioners should broaden their view of mental health, and consider it as a full spectrum ranging from serious mental illness to robust emotional well-being. This perspective recognizes the importance of treatment access and quality, but also elevates the value of prevention, particularly at the population level. Greater attention to preventing problems before they occur will not only reduce manifest disorders but also encourage higher rates of psychological resilience and, ultimately, better physical health.
The Protest Psychosis & the Future of Equity &
Diversity Efforts in American Psychiatry
Authors: Metzl Jonathan M. 
Published: November 2023

Abstract
This essay chronicles the history of medical associations between schizophrenia and Blackness that emerged during the tumultuous decades of the 1960s and 1970s, when American psychiatrists overdiagnosed schizophrenia in Black men in ways that undermined brain science of the era. I provide data to show how racially disparate diagnostic outcomes resulted not solely from the attitudes or biases of clinicians, but from a series of larger political and social determinants, most notably changing frameworks surrounding mental illness and political protest. I conclude by highlighting how training clinicians to examine their own cultural biases also needs to include training in how structures and institutions produce symptoms and diseases, and how we can only build better structures to support health if we can individually and then communally imagine them.
Democracy Therapy: Lessons from ThriveNYC
Authors: Belkin Gary 
Published: November 2023

Abstract
Despite massive unmet needs, U.S. mental health care systems and policy continue to aim too low. Laments about brittle foundations-including inadequate funding, fragmentation, stigma, lack of parity, ineffectiveness, unavailability, overmedicalization, and coercion-all share the same source. The mental health system is not working because it has been chasing the wrong goal: to treat illness, rather than to enable people to do nurturing things together. A focus on community nurturing and caring changes everything. It yields better treatment approaches while also engaging with the mutually reinforcing and desperately needed work of social cohesion, emotional well-being, participatory action, and communal learning and connection. In fact, the nurtured emotional health of individuals is fundamental to humane and resilient societies and to democracy itself. And in the face of environmental collapse and the related unraveling of core institutions, the stakes have never been higher. This essay makes the case for a paradigm shift in care and explores a recent effort to implement it at scale: ThriveNYC. The successes and especially the failures of ThriveNYC point to the possibilities and challenges of this essential mission.
Indigenous Historical Trauma: Alter-Native Explanations for Mental
Health Inequities
Authors: Gone Joseph P. 
Published: November 2023

Abstract
The well-being of American Indian and other Indigenous communities has long been compromised by ruthless processes of European colonial dispossession and subjugation. As a result, contemporary Indigenous communities contend with sometimes overwhelming degrees of demoralization, distress, and disability. The concept of Indigenous historical trauma has arisen during the past thirty years as an alternative mental health discourse that critically contests prevailing categories of psychological disability, psychiatric distress, and mental disorders (including addiction, trauma, and suicide). Indigenous adoption and promotion of historical trauma affords an explanatory account for community mental health inequities that designates the historical legacies of colonization as central for understanding contemporary Indigenous suffering. In so doing, Indigenous advocates of historical trauma creatively recast these problems as postcolonial pathologies, and ardently call for overdue advances in reconciliation, redress, and repair with respect to Indigenous Peoples. Ideally, such advances will be evidenced by societal transformations, structural reforms, and social justice that can enhance and ensure Indigenous futurity and well-being.
The Biology of Mental Disorders: Progress at Last
Authors: Hyman Steven E. 
Published: November 2023

Abstract
Mental disorders are common, complex, highly morbid conditions for which basic underlying mechanisms are poorly understood. Despite the utility of many existing treatments, there remains vast unmet need for more effective and safer therapeutics. Most current medicines for mental disorders are based on chemical modifications of serendipitously discovered mid-twentieth-century prototypes, and widely used diagnostic manuals remain phenomenological and conceptually confused. After decades of stasis, research on mental disorders has reached an inflection point. Unbiased large-scale genetics provides information that, if interpreted circumspectly and integrated with neurobiology, provides “finding tools” for causal biological mechanisms that can advance discovery of biomarkers, preventive interventions, and better treatments. However, uncritically applied predictive genomic technologies can produce fatalism and exacerbate stigma. Moreover, polygenic risk scores for cognitive ability and risk of mental illness are already being offered commercially for embryo selection with in vitro fertilization, a worrisome resurgence of eugenics hiding in liberal (noncoercive) guise.
Can Mental Health Care Become More Human by Becoming More
Digital?
Authors: Galatzer-Levy Isaac R. , Aranovich Gabriel J. , Insel Thomas R. 
Published: November 2023

Abstract
Over the past two decades, advances in digital technologies have begun to transform three aspects of mental health care. The use of sensors and artificial intelligence (AI) have provided new, objective measures of how we think, feel, and behave. The ease of connecting and communicating remotely has transformed the brick-and-mortar practice of mental health care into a telehealth service, increasing access and convenience for both patients and providers. And the advent of digital therapeutics, from virtual reality for treating phobias to conversational agents for delivering structured therapies, promises to alter how treatments will be delivered in the future. These digital transformations can help to solve many of the key challenges facing mental health care, including access, quality, and accountability. But digital technology introduces a new set of challenges around trust, privacy, and equity. Despite high levels of investment and promotion, there remain profound questions about efficacy and safety of digital mental health technologies. We share our experiences from the front lines creating digital innovations for mental health, with a focus on what a digital transformation of care could deliver for millions with a serious mental illness.
Empowering the (Extra)Ordinary
Authors: Patel Vikram , Rahman Atif 
Published: November 2023

Abstract
Psychological treatments are among the most effective interventions for a wide range of mental health conditions but remain inaccessible to most people who could benefit from them, including in many high-income countries. We describe two case studies from South Asia that demonstrate innovatively designed psychological treatments addressing many of the barriers that limit their scalability. The treatments are brief, less complex, and delivered by frontline providers, such as peer counselors in community settings. These case studies, alongside a large and growing literature from around the world, provide the foundation for a paradigm shift in mental health care by rejecting the nihilistic notion that communities do not have enough resources to address mental health problems or that these problems are too complex to address. Central to this notion is the recognition that mental health problems can be addressed effectively with resources that every community possesses: people who care for others in their communities.
Morphological and genetic diversification of Old-World marbled newts, with the description of a new and ‘not-at-all-cryptic’ subspecies from the Iberian Peninsula (Triturus, Salamandridae)
Authors: Arntzen Jan W. 
Published: November 2023

Abstract
Morphological and genetic variation of organisms is generally lower in northern than in southern regions of the Palearctic. This ubiquitous geographical pattern has been associated with extinction and recolonization processes in the north versus persistence in the Mediterranean area, as governed by climate change in the Pleistocene. One area of differentiation and complexity is the Iberian Peninsula where two distinct sister-species of marbled newts possess adjoining and geographically sharply delimited ranges over the north (Triturus marmoratus) and the south of the peninsula (T. pygmaeus). Within the latter species two forms are here documented, with different colouration patterns and non-overlapping ranges. The southern form is striped, much as in T. marmoratus, and occurs to the south of the Guadalquivir River. The northern form, here described as a new subspecies, has a reticulated dorsal colouration. It occurs only north of the Guadalquivir and is thus sandwiched in between two striped marbled newt taxa. Both T. pygmaeus subspecies engage inside the Doñana National Park in a ca. 2,500 m narrow contact zone. Although an inferred substantial selection against hybrids goes a long way to support species status, a reanalysis of published genetic data is required to solve this issue, along with the wider investigation of the same type of (microsatelite) data for the southern, nominotypical subspecies.
The Jeffersonian Republicans and the Democratic Movement
Authors: Dingeldey Philip 
Published: November 2023

Abstract
Against those who argue that the term democracy only became a broadly positive term in the 19th century, this article shows that it already had become a positive political term in the 1790s in the USA. With the Jeffersonian revolution, groups that used democracy positively triumphed over the anti-democratic Federalists. By transforming the connotation of the word democracy, however, Democratic Republicans also transformed the concept/theory associated with it – from radical direct democracy to a representative system.
Coffee Leaf Traits, Bean Quality and Biochemistry across Elevation and Shade Gradients in Ethiopia
Authors: Getachew Merkebu 
Published: November 2023

Abstract
According to model projections, coffee cultivation areas will need to move to higher elevations as suitability moves upslope to compensate for increased temperatures. However, shifting coffee-growing areas upslope may bring conflicts with land use and crops other than coffee and induce adverse socio-economic and environmental impacts associated with deforestation for new coffee cultivation. Moreover, model projections are largely limited to ex-situ experiments based on downscaled global climate models, and thus empirical data are still needed to assess climate change impacts on coffee production in Ethiopia in the future. Furthermore, conditions such as shade tree canopy closure, soil fertility and elevation may either ameliorate or exacerbate climate change impacts. In the absence of significant interventions, this could result in considerable land use change, increased vulnerability of coffee-dependent livelihoods and a potential shortage of coffee supply. Hence, to generate trustworthy and accurate information for climate-resilient Ethiopian coffee production, more field-based experiments are needed. In this PhD thesis, I used coffee plants growing at contrasting elevations using a space-for-time substitution approach for warming in south-west Ethiopia. The coffee plants were superimposed under various shade tree species with multi-strata canopy architecture. The potential of increasing canopy closure in modulating responses to increasing temperature, and the associated effect on coffee plant traits, green bean quality and biochemistry, were thoroughly explored. Based on my findings, I was able to identify potential limiting factors, to close the coffee quality gap by providing improved management recommendations tailored to the local ecological conditions while acknowledging the dynamic drivers (mainly resource availability and climatic variability) for the long-term sustainability of the coffee industry.
The New Life of the Yurt
Authors: Lamazhaa Chimiza K. 
Published: November 2023

Abstract
The yurt has always been a crucial element of Tuvan culture and the economy of cattle herding, especially for those who keep up the herding tradition. However, their number is small, with most Tuvans living in villages or towns and working in other industries. But the yurt has never been forgotten even by settled Tuvans. The article examines the presence of the yurt (Tuvan ög), the traditional dwelling of nomadic cattle herders in the various spheres of the socio-cultural life in the Republic of Tuva. It is an anthropological study of nostalgic nomadism, a contemporary aspect of nomadism when descendants of original nomads remember the past of their ancestor, feel nostalgic about and accept its elements as their own contemporary cultural values. The study is based on observations made in Tuva from 2014 to 2021 and interviews with Tuvans of different generations in 2021–22.
Data Collaboration: the Aftermath of Operation Sirli
Authors: Hanon Jean Paul , Bigo Didier 
Published: November 2023

Abstract
This article analyses the collaboration between the French external services and the Egyptian government of President Sissi. In a first part, it recounts the revelations of the Disclose journalists in 2021 and their interview with an anonymous source, as well as the follow-up investigation in 2023 by the European Consortium of Independent Journalists. In the second part, the two authors comment on the relationship between data cooperation and counter-terrorism activities, the way in which the sale of arms and spying tools undermines the legitimacy of cooperation, and the way in which the French government has used the argument of defence of secrecy to prevent investigative journalists from investigating the issue.
Climate Change Litigation before International Human Rights Bodies: Insights from Daniel Billy et al. v. Australia (Torres Strait Islanders Case)
Authors: Luporini Riccardo 
Published: November 2023

Abstract
The article examines Daniel Billy et al. v. Australia, also known as the Torres Strait Islanders case, decided by the United Nations Human Rights Committee. The case stands out as the first instance in which an international (quasi-) judicial body has found human rights violations in the context of an individual complaint concerning climate change. The article sets out three main considerations arising from the case. First, it delves into the specificities of the case in relation to some of the common constraints to climate complaints before international human rights bodies. Second, it outlines the distinctive aspects of human rights arguments when applied to climate change adaptation, as opposed to mitigation. Third, it underscores the need to further investigate the multidimensional impact of climate change litigation before international human rights bodies.