bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paper promises: Peruvian frontline health workers’ perspectives on mental health policies during COVID-19
Authors: Mayo-Puchoc Nikol , Bejarano-Carranza Jenny , Paredes-Angeles Rubí , Vilela-Estrada Ana Lucía , García-Serna Jackeline , Cusihuaman-Lope Noelia , Villarreal-Zegarra David , Cavero Victoria , Ardila-Gómez Sara 
Published: November 2023

Abstract
Governments globally deployed various non-pharmacological public health measures to respond to the COVID-19 pandemic (i.e. lockdowns and suspension of transportation, amongst others); some of these measures had an influence on society’s mental health. Specific mental health policies were therefore implemented to mitigate the potential mental health impact of the pandemic. We aimed to explore the implementation of mental health regulations adopted by the Peruvian health system by focusing on the care services at Community Mental Health Centres (CMHCs), based on the experiences of health workers. We conducted a phenomenological qualitative study to understand the implementation of mental health policies launched in Peru during the COVID-19 pandemic. Data were obtained from a document review of 15 national policy measures implemented during the pandemic (March 2020 to September 2021), and 20 interviews with health workers from CMHCs (September 2021 to February 2022). The analysis was conducted using thematic content analysis. Most implemented policies adapted CMHC care services to a virtual modality during the COVID-19 pandemic; however, various challenges and barriers were evidenced in the process, which prevented effective adaptation of services. Workers perceived that ineffective telemedicine use was attributed to a gap in access to technology at the CMHCs and also by users, ranging from limited access to technological devices to a lack of technological skills. Further, although mental health promotion and prevention policies targeting the community were proposed, CMHC staff reported temporary interruption of these services during the first wave. The disparity between what is stated in the regulations and the experiences of health workers is evident. Policies that focus on mental health need to provide practical and flexible methods taking into consideration both the needs of CMHCs and socio-cultural characteristics that may affect their implementation.
Oriented Right-Angled Artin Pro-ℓ Groups and Maximal Pro-ℓ Galois Groups
Authors: Blumer Simone , Quadrelli Claudio , Weigel Thomas S 
Published: November 2023

Abstract
For a prime number $\ell $, we introduce and study oriented right-angled Artin pro-$\ell $ groups $G_{\Gamma ,\lambda }$(oriented pro-$\ell $ RAAGs for short) associated to a finite oriented graph $\Gamma $ and a continuous group homomorphism $\lambda \colon{\mathbb{Z}}_{\ell }\to{\mathbb{Z}}_{\ell }^{\times }$. We show that an oriented pro-$\ell $ RAAG $G_{\Gamma ,\lambda }$ is a Bloch–Kato pro-$\ell $ group if, and only if, $(G_{\Gamma ,\lambda },\theta _{\Gamma ,\lambda })$ is an oriented pro-$\ell $ group of elementary type, generalizing a recent result of I. Snopce and P. Zalesskiĭ—here $\theta _{\Gamma ,\lambda }\colon G_{\Gamma ,\lambda }\to{\mathbb{Z}}_{\ell}^{\times }$ denotes the canonical $\ell $-orientation on $G_{\Gamma ,\lambda }$. This yields a plethora of new examples of pro-$\ell $ groups that are not maximal pro-$\ell $ Galois groups. We invest some effort in order to show that oriented right-angled Artin pro-$\ell $ groups share many properties with right-angled Artin pro-$\ell $-groups or even discrete RAAG’s, for example, if $\Gamma $ is a specially oriented chordal graph, then $G_{\Gamma ,\lambda }$ is coherent generalizing a result of C. Droms. Moreover, in this case, $(G_{\Gamma ,\lambda },\theta _{\Gamma ,\lambda })$ has the Positselski–Bogomolov property generalizing a result of H. Servatius, C. Droms, and B. Servatius for discrete RAAG’s. If $\Gamma $ is a specially oriented chordal graph and $\operatorname{Im}(\lambda )\subseteq 1+4{\mathbb{Z}}_{2}$ in case that $\ell =2$, then $H^{\bullet }(G_{\Gamma ,\lambda },{\mathbb{F}}_{\ell }) \simeq \Lambda ^{\bullet }(\ddot{\Gamma }^{\textrm{op}})$ generalizing a well-known result of M. Salvetti (cf. [ 39]). Dedicated to the memory of Avinoam Mann.
Variola Virus and Clade I Mpox Virus Differentially Modulate Cellular Responses Longitudinally in Monocytes During Infection
Authors: Wahl Victoria , Olson Victoria A , Kondas Ashley V , Jahrling Peter B , Damon Inger K , Kindrachuk Jason 
Published: November 2023

Abstract
Variola virus (VARV), the etiological agent of smallpox, had enormous impacts on global health prior to its eradication. In the absence of global vaccination programs, mpox virus (MPXV) has become a growing public health threat that includes endemic and nonendemic regions across the globe. While human mpox resembles smallpox in clinical presentation, there are considerable knowledge gaps regarding conserved molecular pathogenesis between these 2 orthopoxviruses. Thus, we sought to compare MPXV and VARV infections in human monocytes through kinome analysis. We performed a longitudinal analysis of host cellular responses to VARV infection in human monocytes as well as a comparative analysis to clade I MPXV-mediated responses. While both viruses elicited strong activation of cell responses early during infection as compared to later time points, several key differences in cell signaling events were identified and validated. These observations will help in the design and development of panorthopoxvirus therapeutics.
Surveillance of Complicated Mpox Cases Unresponsive to Oral Tecovirimat in Los Angeles County, 2022
Authors: Karan Abraar , Shah Naman , Garrigues Jacob M , Alarcόn Jemma , Hemarajata Peera , Finn Lauren E , Poortinga Kathleen , Danza Phoebe , Kulkarni Sonali , Kim Moon , Terashita Dawn , Green Nicole M , Balter Sharon 
Published: November 2023

Abstract
The Los Angeles County Department of Public Health established a surveillance system to identify complicated (advanced human immunodeficiency virus [HIV] or hospitalized) mpox cases. From 1 August to 30 November 2022, we identified 1581 mpox cases, of which 134 (8.5%) were complicated. A subset of 8 cases did not recover after either initiating or completing a course of oral tecovirimat. All 8 patients were HIV positive and had advanced HIV (CD4 count &lt;200 cells/μL). We identified 8 distinct mutations previously associated with tecovirimat resistance in specimens collected from 6 patients. Ongoing surveillance of viral evolution requires close coordination between health departments and frontline providers.
The Experience of Neurodiverse and Disabled People in IT
Authors: Runciman Brian 
Published: November 2023

Abstract
In 2022 BCS focused on the experience of black women in IT as a leader into our regular diversity analysis. For 2023 we are focusing on the experience of disabled and neurodivergent people who work in IT. Brian Runciman MBCS gives a taster of the forthcoming report.
Signal Processing and Machine Learning Algorithm to Classify Anaesthesia Depth
Authors: Powell Grant 
Published: November 2023

Abstract
Volume 30, Issue 1 of the BMJ Health and Care Informatics Journal features a new piece of original research. Oscar Mosquera Dussan, Eduardo Tuta-Quintero and Dr Daniel A. Botero-Rosas present the findings of a study into how information can impact on the monitoring of anaesthetic depth (AD) during surgical procedures.
SARS-CoV-2 genomics and impact on clinical care for COVID-19
Authors: Lorenzo-Redondo Ramon , de Sant’Anna Carvalho Alexandre Machado , Hultquist Judd F , Ozer Egon A 
Published: November 2023

Abstract
The emergence and worldwide spread of SARS-CoV-2 during the COVID-19 pandemic necessitated the adaptation and rapid deployment of viral WGS and analysis techniques that had been previously applied on a more limited basis to other viral pathogens, such as HIV and influenza viruses. The need for WGS was driven in part by the low mutation rate of SARS-CoV-2, which necessitated measuring variation along the entire genome sequence to effectively differentiate lineages and characterize viral evolution. Several WGS approaches designed to maximize throughput and accuracy were quickly adopted by surveillance labs around the world. These broad-based SARS-CoV-2 genomic sequencing efforts revealed ongoing evolution of the virus, highlighted by the successive emergence of new viral variants throughout the course of the pandemic. These genomic insights were instrumental in characterizing the effects of viral mutations on transmissibility, immune escape and viral tropism, which in turn helped guide public health policy, the use of monoclonal antibody therapeutics and vaccine development strategies. As the use of direct-acting antivirals for the treatment of COVID-19 became more widespread, the potential for emergence of antiviral resistance has driven ongoing efforts to delineate resistance mutations and to monitor global sequence databases for their emergence. Given the critical role of viral genomics in the international effort to combat the COVID-19 pandemic, coordinated efforts should be made to expand global genomic surveillance capacity and infrastructure towards the anticipation and prevention of future pandemics.
Lessons identified for a future pandemic
Authors: Cunningham Neil , Hopkins Susan 
Published: November 2023

Abstract
Pandemics are complex events requiring a coordinated, global response. The response to the pandemic exposed vulnerabilities in system preparedness.
Lessons arising from the COVID-19 pandemic are characterized by four broad themes: (i) investment in public health and health infrastructure, (ii) countermeasures (medical and non-medical), (iii) risk communication and public health measures and (iv) investment in people and partnerships.
Learning from the COVID-19 pandemic identifies an approach that focusses on capacities and capabilities that are pathogen agnostic, ensuring that we can respond to diverse emerging infectious disease threats will be essential. The lessons learned from previous and ongoing infectious disease outbreaks should be kept under constant review, in line with technological and scientific advances, to improve our ability to detect, mitigate and respond to new and emerging threats.
An overview of COVID-19 global epidemiology and discussion of potential drivers of variable global pandemic impacts
Authors: Ashmore Polly , Sherwood Emma 
Published: November 2023

Abstract
With a WHO-estimated excess mortality burden of 14.9 million over the course of 2020 and 2021, the COVID-19 pandemic has had a major human impact so far. It has also affected a range of disciplines, systems and practices from mathematical modelling to behavioural sciences, pharmaceutical development to health system management. This article explores these developments and, to set the scene, this paper summarizes the global epidemiology of COVID-19 from January 2020 to June 2021 and considers some potential drivers of variation.
Multi-dimensional condensation of intracellular biomolecules
Authors: Yanagawa Masataka , Shimobayashi Shunsuke F 
Published: November 2023

Abstract
Liquid–liquid phase separation has been recognized as universal mechanisms in living cells for the formation of RNA-protein condensates and ordered lipid domains. These biomolecular condensates or domains nucleate, diffuse and interact with each other across physical dimensions to perform their biological functions. Here we summarize key features of biophysical principles underlying the multi-dimensional condensation of RNA-protein condensates and ordered lipid domains, which are related to nuclear transcription, and signaling on cell membranes. Uncovering physicochemical factors that govern the spatiotemporal coupling of those condensates presents a new avenue in their functions and associated human diseases.
Extension of theglmm.hppackage to zero-inflated generalized linear mixed models and multiple regression
Authors: Lai Jiangshan , Zhu Weijie , Cui Dongfang , Mao Lingfeng 
Published: November 2023

Abstractglmm.hp is an R package designed to evaluate the relative importance of collinear predictors within generalized linear mixed models (GLMMs). Since its initial release in January 2022, it has been rapidly gained recognition and popularity among ecologists. However, the previous glmm.hp package was limited to work GLMMs derived exclusively from the lme4 and nlme packages. The latest glmm.hp package has extended its functions. It has integrated results obtained from the glmmTMB package, thus enabling it to handle zero-inflated generalized linear mixed models (ZIGLMMs) effectively. Furthermore, it has introduced the new functionalities of commonality analysis and hierarchical partitioning for multiple linear regression models by considering both unadjusted R2 and adjusted R2. This paper will serve as a demonstration for the applications of these new functionalities, making them more accessible to users.
Hypoxia-induced one-carbon metabolic reprogramming in glioma stem-like cells
Authors: He Xuan-Cheng , Wang Jian , Shi Min-Yang , Liu Chang-Mei , Teng Zhao-Qian 
Published: November 2023

Abstract
Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression, and recurrence in glioblastoma (GBM). Metabolic pathways are altered in GSCs under hypoxia, but the mechanism underlying the altered one-carbon metabolism in GSCs by hypoxia is largely unknown. Here, we report that hypoxia induces down-regulation of DHFR as well as up-regulation of MAT2A in GBM tumorsphere cells, and confers them the ability of cell proliferation that is independent of exogenous folate. Importantly, short-term inhibition of the methionine cycle or exposure to the MAT2A inhibitor is sufficient to cripple the tumor-initiating capability of GBM tumorsphere cells. Therefore, we present a novel perspective on how hypoxia alters the pattern of one-carbon metabolism in GBM tumorsphere cells and provide evidence that restriction of methionine intake or targeting MAT2A inhibits the tumorigenicity of GBM tumorsphere cells.
Memory and the Human Anterior Thalamus
Authors: Sweeney-Reed Catherine M. , Knight Robert T. 
Published: November 2023

Abstract
The cerebral cortex and hippocampus are well-established as key brain structures in memory processing. The role of the cerebral cortex in human memory has been extensively investigated due to the wide availability of electroencephalography (EEG), which enables non-invasive electrophysiological recordings of cortical activity during memory formation, storage, and retrieval, and because the spatial resolution of functional neuroimaging allows identification of modulation of brain activity in functionally specialized cortical regions during memory processing. Animal and human lesion, as well as neuroimaging studies, also indicate engagement of the anterior nuclei of the thalamus (ANT) in memory processing, and the extensive cortical and hippocampal anatomical connectivity of the ANT has led to the proposal that they are key a part of an extended memory system. The recent introduction of deep brain stimulation of the ANT to treat refractory epilepsy has opened new avenues for examining the role of these structures in human memory, both through evaluation of the effects of perturbing ANT electrical activity on memory performance during stimulation, and recordings of electrophysiological signals directly from the ANT during memory processing. Simultaneous EEG recording of cortical activity has also enabled insights into how the cerebral cortex and ANT interact during memory processing, with the findings providing evidence that the ANT, and their interactions with cerebral cortex, play a critical role in memory formation.
Bronchial aspirate obtained during bronchoscopy yields increased fungal load compared to bronchoalveolar lavage fluid in patients at risk of invasive aspergillosis and Pneumocystis pneumonia
Authors: Dellière Sarah , Amar Yaël , Hamane Samia , Aissaoui Nesrine , Denis Blandine , Bergeron Anne , Tazi Abdellatif , Alanio Alexandre 
Published: November 2023

Abstract
Bronchoalveolar lavage fluid (BALF) is a standard respiratory sample for diagnosing invasive fungal diseases like Pneumocystis pneumonia (PCP) and invasive pulmonary aspergillosis (IPA). However, procedural variations exist across medical centers and wards. This study aimed to compare the diagnostic potential of BALF and bronchial aspirate (BA) obtained during bronchoscopy in 173 patients suspected of fungal infections. A prospective observational study was conducted from April 2020 to November 2021. BALF and BA were collected during bronchoscopy and subjected to direct examination, fungal culture, Aspergillus fumigatus qPCR (AfqPCR), and Pneumocystis jirovecii qPCR (PjqPCR). Galactomannan detection was performed on BALF. Patients were classified based on established European Organization for Research and Treatment of Cancer (EORTC) criteria. Out of 173 patients, 75 tested positive for at least one test in BA or BALF. For Aspergillus, proportion of positive AfqPCR (14.5% vs. 9.2%; P &lt; 0.0001) and fungal loads (Cq of 31.3 vs. 32.8; P = 0.0018) were significantly higher in BA compared to BALF. For Pneumocystis, fungal loads by PjqPCR was also higher in BA compared to BALF (Cq of 34.2 vs. 35.7; P = 0.003). BA only detected A. fumigatus and P. jirovecii in 12 (42.9%) and 8 (19.5%) patients, respectively. BA obtained during a BAL procedure can be a suitable sample type for increased detection of P. jirovecii and A. fumigatus by qPCR. The use of BA in diagnostic algorithms requires further investigation in prospective studies.
G213.0−0.6, a true supernova remnant or just an H  ii region?
Authors: Gao X Y , Wu C J , Sun X H , Reich W , Han J L 
Published: November 2023

ABSTRACT
G213.0−0.6 is a faint extended source situated in the anticentre region of the Galactic plane. It has been classified as a shell-type supernova remnant (SNR) based on its shell-like morphology, steep radio continuum spectrum, and high ratio of [S ii]/Hα. With new optical emission line data of Hα, [S ii], and [N ii] recently observed by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope, the ratios of [S ii]/Hα and [N ii]/Hα are re-assessed. The lower values than those previously reported put G213.0−0.6 around the borderline of SNR-H ii region classification. We decompose the steep-spectrum synchrotron and the flat-spectrum thermal free-free emission in the area of G213.0−0.6 with multi-frequency radio continuum data. G213.0−0.6 is found to show a flat spectrum, in conflict with the properties of a shell-type SNR. Such a result is further confirmed by TT-plots made between the 863-MHz, 1.4-GHz, and 4.8-GHz data. Combining the evidence extracted in both optical and radio continuum, we argue that G213.0−0.6 is possibly not an SNR, but an H ii region instead. The VLSR pertaining to the Hα filaments places G213.0−0.6 approximately 1.9 kpc away in the Perseus Arm.
On the stability and pulsation in models of B[e] star MWC 137
Authors: Parida Sugyan , Yadav Abhay Pratap , Kraus Michaela , Glatzel Wolfgang , Joshi Yogesh Chandra , Joshi Santosh 
Published: November 2023

ABSTRACT
B[e] type stars are characterized by strong emission lines, photometric, and spectroscopic variabilities and unsteady mass-loss rates. MWC 137 is a galactic B[e] type star situated in the constellation Orion. Recent photometric observation of MWC 137 by TESS has revealed variabilities with a dominant period of 1.9 d. The origin of this variability is not known but suspected to be from stellar pulsation. To understand the nature and origin of this variability, we have constructed three different set of models of MWC 137 and performed non-adiabatic linear stability analysis. Several low order modes are found to be unstable in which models having mass in the range of 31–34 M⊙ and 43–46 M⊙ have period close to 1.9 d. The evolution of instabilities in the non-linear regime for model having solar chemical composition and mass of 45 M⊙ leads to finite amplitude pulsation with a period of 1.9 d. Therefore, in the present study we confirm that this variability in MWC 137 is due to pulsation. Evolutionary tracks passing through the location of MWC 137 in the Hertzsprung–Russell diagram indicate that the star is either in post main sequence evolutionary phase or about to enter in this evolutionary phase.
Inference of Admixture Origins in Indigenous African Cattle
Authors: Kim Kwondo , Kim Donghee , Hanotte Olivier , Lee Charles , Kim Heebal , Jeong Choongwon 
Published: November 2023

Abstract
Present-day African cattle retain a unique genetic profile composed of a mixture of the Bos taurus and Bos indicus populations introduced into the continent at different time periods. However, details of the admixture history and the exact origins of the source populations remain obscure. Here, we infer the source of admixture in the earliest domestic cattle in Africa, African taurine. We detect a significant contribution (up to ∼20%) from a basal taurine lineage, which might represent the now-extinct African aurochs. In addition, we show that the indicine ancestry of African cattle, although most closely related to so-far sampled North Indian indicine breeds, has a small amount of additional genetic affinity to Southeast Asian indicine breeds. Our findings support the hypothesis of aurochs introgression into African taurine and generate a novel hypothesis that the origin of indicine ancestry in Africa might be different indicine populations than the ones found in North India today.
EMDB—the Electron Microscopy Data Bank
Authors:   The wwPDB Consortium, Turner Jack , Abbott Sanja , Fonseca Neli , Pye Ryan , Carrijo Lucas , Duraisamy Amudha Kumari , Salih Osman , Wang Zhe , Kleywegt Gerard J , Morris Kyle L , Patwardhan Ardan , Burley Stephen K , Crichlow Gregg , Feng Zukang , Flatt Justin W , Ghosh Sutapa , Hudson Brian P , Lawson Catherine L , Liang Yuhe , Peisach Ezra , Persikova Irina , Sekharan Monica , Shao Chenghua , Young Jasmine , Velankar Sameer , Armstrong David , Bage Marcus , Bueno Wesley Morellato , Evans Genevieve , Gaborova Romana , Ganguly Sudakshina , Gupta Deepti , Harrus Deborah , Tanweer Ahsan , Bansal Manju , Rangannan Vetriselvi , Kurisu Genji , Cho Hasumi , Ikegawa Yasuyo , Kengaku Yumiko , Kim Ju Yaen , Niwa Satomi , Sato Junko , Takuwa Ayako , Yu Jian , Hoch Jeffrey C , Baskaran Kumaran , Xu Wenqing , Zhang Weizhe , Ma Xiaodan 
Published: November 2023

Abstract
The Electron Microscopy Data Bank (EMDB) is the global public archive of three-dimensional electron microscopy (3DEM) maps of biological specimens derived from transmission electron microscopy experiments. As of 2021, EMDB is managed by the Worldwide Protein Data Bank consortium (wwPDB; wwpdb.org) as a wwPDB Core Archive, and the EMDB team is a core member of the consortium. Today, EMDB houses over 30 000 entries with maps containing macromolecules, complexes, viruses, organelles and cells. Herein, we provide an overview of the rapidly growing EMDB archive, including its current holdings, recent updates, and future plans.