bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between early postoperative hypoalbuminaemia and outcome after orthotopic heart transplantation
Authors: M’Pembele René , Roth Sebastian , Jenkins Freya , Hettlich Vincent , Nucaro Anthony , Stroda Alexandra , Tenge Theresa , Polzin Amin , Ramadani Bedri , Lurati Buse Giovanna , Aubin Hug , Lichtenberg Artur , Huhn Ragnar , Boeken Udo 
Published: January 2024

Abstract

OBJECTIVES
In patients undergoing heart transplantation (HTX), preoperative liver impairment and consecutive hypoalbuminaemia are associated with increased mortality. The role of early postoperative hypoalbuminaemia after HTX is unclear. This study investigated the association between early postoperative hypoalbuminaemia and 1-year mortality as well as ‘days alive and out of hospital’ (DAOH) after HTX.

METHODS
This retrospective cohort study included patients who underwent HTX at the University Hospital Duesseldorf, Germany, between 2010 and 2022. The main exposure was serum albumin concentration at intensive care unit (ICU) arrival. The primary endpoints were mortality and DAOH within 1 year after surgery. Receiver operating characteristic (ROC) curve analysis was performed and logistic and quantile regression models with adjustment for 13 a priori defined clinical risk factors were conducted.

RESULTS
Out of 241 patients screened, 229 were included in the analysis (mean age 55 ± 11 years, 73% male). ROC analysis showed moderate discrimination for 1-year mortality by postoperative serum albumin after HTX [AUC = 0.74; 95% confidence interval (CI): 0.66–0.83]. The cutoff for serum albumin at ICU arrival was 3.0 g/dl. According to multivariate logistic and quantile regression, there were independent associations between hypoalbuminaemia and mortality/DAOH [odds ratio of 4.76 (95% CI: 1.94–11.67) and regression coefficient of −46.97 (95% CI: −83.81 to −10.13)].

CONCLUSIONS
Postoperative hypoalbuminaemia &lt;3.0 g/dl is associated with 1-year mortality and reduced DAOH after HTX and therefore might be used for early postoperative risk re-assessment in clinical practice.
On the pursuit to reconstitute the Escherichia coli ribosome from purified components
Authors: Taguchi Hideki 
Published: January 2024

Abstract
The ribosome, the protein synthesizing machinery composed of dozens of proteins and several ribosomal RNAs (rRNAs), is essential for life. In vitro reconstitution of the ribosome holds significance for understanding biosynthesis, applications in biotechnology and potential contributions to synthetic biology. There is a long history of in vitro reconstitution of bacterial ribosomes, originating in the 1970s when the 30S ribosome of Escherichia coli was reconstituted from the protein and rRNA components prepared from native ribosome. Since then, the reconstitution using in vitro transcribed rRNAs has been established, and more recently, the reconstitution using recombinant ribosomal proteins has also become possible. A recent report by Aoyama et al. (J. Biochem. 2022; 171:227–237), the reconstitution of the 50S ribosome using 33 recombinant ribosomal proteins, is a new leap toward complete reconstitution of the holo ribosome complex from recombinant proteins and in vitro transcribed rRNAs. This commentary also discusses future challenges.
Boosting aquila optimizer by marine predators algorithm for combinatorial optimization
Authors: Wang Shuang , Jia Heming , Hussien Abdelazim G , Abualigah Laith , Lin Guanjun , Wei Hongwei , Lin Zhenheng , Dhal Krishna Gopal 
Published: January 2024

Abstract
In this study, an improved version of aquila optimizer (AO) known as EHAOMPA has been developed by using the marine predators algorithm (MPA). MPA is a recent and well-behaved optimizer with a unique memory saving and fish aggregating devices mechanism. At the same time, it suffers from various defects such as inadequate global search, sluggish convergence, and stagnation of local optima. However, AO has contented robust global exploration capability, fast convergence speed, and high search efficiency. Thus, the proposed EHAOMPA aims to complement the shortcomings of AO and MPA while bringing new features. Specifically, the representative-based hunting technique is incorporated into the exploration stage to enhance population diversity. At the same time, random opposition-based learning is introduced into the exploitation stage to prevent the optimizer from sticking to local optima. This study tests the performance of EHAOMPA’s on 23 standard mathematical benchmark functions, 29 complex test functions from the CEC2017 test suite, six constrained industrial engineering design problems, and a convolutional neural network hyperparameter (CNN-hyperparameter) optimization for Corona Virus Disease 19 (COVID-19) computed tomography-image detection problem. EHAOMPA is compared with four existing optimization algorithm types, achieving the best performance on both numerical and practical issues. Compared with other methods, the test function results demonstrate that EHAOMPA exhibits a more potent global search capability, a higher convergence rate, increased accuracy, and an improved ability to avoid local optima. The excellent experimental results in practical problems indicate that the developed EHAOMPA has great potential in solving real-world optimization problems. The combination of multiple strategies can effectively improve the performance of the algorithm. The source code of the EHAOMPA is publicly available at https://github.com/WangShuang92/EHAOMPA.
Trastuzumab deruxtecan in patients with human epidermal growth factor receptor 2–expressing salivary gland carcinoma: a pooled analysis of two phase I studies
Authors: Takahashi Shunji , Bando Hideaki , Kinoshita Ichiro , Modi Shanu , Tsurutani Junji , Bang Yung-Jue , Sato Yuta , Nakatani Shunsuke , Lee Caleb , Sugihara Masahiro , Okuda Yasuyuki , Iwata Hiroji 
Published: January 2024

Abstract

Background
HER2-expressing salivary gland carcinoma (SGC) is associated with poor prognosis. Trastuzumab deruxtecan (T-DXd, DS-8201) has shown evidence of antitumor activity for several HER2-expressing solid tumors in multiple studies. This study aimed to present the efficacy and safety of T-DXd in patients with HER2-expressing SGC from a pooled analysis.

Methods
Patients with HER2-expressing SGC were pooled from two phase I, open-label studies of T-DXd: a two-phase, multiple-dose, first-in-human study (NCT02564900) and a single-sequence crossover drug–drug interaction study (NCT03383692). Endpoints included efficacy (objective response rate [ORR], duration of response [DoR] and progression-free survival [PFS]) and safety.

Results
This pooled analysis included 17 patients with SGC (median age: 57 years; male: 88.2%); median (range) follow-up duration was 12.0 (2.3–‍34.8) months. Among these patients, 14 had received prior HER2-targeted agents and 13 had undergone prior radiotherapy. The investigator-assessed confirmed ORR was 58.8% (95% confidence interval [CI], 32.9–‍81.6). The median (95% CI) DoR and PFS were 17.6 months (4.0 to not evaluable [NE]) and 20.5 months (11.1–NE), respectively. All 17 patients reported treatment-emergent adverse events (TEAEs); 76.5% reported TEAEs of grade ≥3. The most common TEAEs were decreased appetite (94.1%), nausea (88.2%) and neutrophil count decreased (76.5%). Of the 17 patients, five (29.4%) reported adjudicated drug-related interstitial lung disease (grade 1, n = 3; grade 2, n =1; grade 3, n = 1).

Conclusion
The results of this pooled analysis provide evidence that clinical benefit is achievable with T-DXd in patients with HER2-expressing SGC.

Clinical trial information
FIH study, NCT02564900; DDI study, NCT03383692
Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations
Authors: Maillard Maud , Nishii Rina , Yang Wenjian , Hoshitsuki Keito , Chepyala Divyabharathi , Lee Shawn H R , Nguyen Jenny Q , Relling Mary V , Crews Kristine R , Leggas Mark , Singh Meenu , Suang Joshua L Y , Yeoh Allen E J , Jeha Sima , Inaba Hiroto , Pui Ching-Hon , Karol Seth E , Trehan Amita , Bhatia Prateek , Antillon Klussmann Federico G , Bhojwani Deepa , Haidar Cyrine E , Yang Jun J 
Published: January 2024

Abstract

Background
Thiopurines such as mercaptopurine (MP) are widely used to treat acute lymphoblastic leukemia (ALL). Thiopurine-S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) inactivate thiopurines, and no-function variants are associated with drug-induced myelosuppression. Dose adjustment of MP is strongly recommended in patients with intermediate or complete loss of activity of TPMT and NUDT15. However, the extent of dosage reduction recommended for patients with intermediate activity in both enzymes is currently not clear.

Methods
MP dosages during maintenance were collected from 1768 patients with ALL in Singapore, Guatemala, India, and North America. Patients were genotyped for TPMT and NUDT15, and actionable variants defined by the Clinical Pharmacogenetics Implementation Consortium were used to classify patients as TPMT and NUDT15 normal metabolizers (TPMT/NUDT15 NM), TPMT or NUDT15 intermediate metabolizers (TPMT IM or NUDT15 IM), or TPMT and NUDT15 compound intermediate metabolizers (TPMT/NUDT15 IM/IM). In parallel, we evaluated MP toxicity, metabolism, and dose adjustment using a Tpmt/Nudt15 combined heterozygous mouse model (Tpmt+/−/Nudt15+/−).

Results
Twenty-two patients (1.2%) were TPMT/NUDT15 IM/IM in the cohort, with the majority self-reported as Hispanics (68.2%, 15/22). TPMT/NUDT15 IM/IM patients tolerated a median daily MP dose of 25.7 mg/m2 (interquartile range = 19.0-31.1 mg/m2), significantly lower than TPMT IM and NUDT15 IM dosage (P &lt; .001). Similarly, Tpmt+/−/Nudt15+/− mice displayed excessive hematopoietic toxicity and accumulated more metabolite (DNA-TG) than wild-type or single heterozygous mice, which was effectively mitigated by a genotype-guided dose titration of MP.

Conclusion
We recommend more substantial dose reductions to individualize MP therapy and mitigate toxicity in TPMT/NUDT15 IM/IM patients.
Recreational substance use among international travellers
Authors: Charoensakulchai Sakarn , Onwan Manasvin , Kanchanasurakit Sukrit , Flaherty Gerard , Matsee Wasin 
Published: January 2024

Abstract

Background
Drug tourism reflects the expanding illicit drug market, posing health risks in unfamiliar travel settings. Existing knowledge specifically addressing substance use among international travellers is sparse and has not been reviewed to date. This review aimed to describe the recreational substance abuse in international travellers.

Methods
A literature search was conducted on PubMed, Google Scholar and Scopus using keywords related to recreational substances and international travellers. A total of 11 021 articles were reviewed, charted and summarized for the evidence on prevalence, patterns and characteristics of substance abuse and their health- and non-health-related problems on international travellers.

Results
A total of 58 articles were included. Most were cross-sectional studies and review articles. In total, 20 articles addressed the prevalence of substance abuse in travellers, 33 looked at characteristics and patterns of substance abuse in travellers and 39 investigated the health- and non-health-related problems from substance abuse. Estimated prevalence of recreational substances abuse varied from 0.7% to 55.0%. Rates of substances abuse were 9.45–34.5% for cannabis, 20.4–35.9% for alcohol intoxication, 2.82–40.5% for MDMA, 2–22.2% for cocaine, 2–15% for psychedelic agents and 2% for methamphetamine. The prevalence varied according to travellers’ characteristics and travel destinations. Direct health problems included neuropsychiatric problems. Indirect problems included accident and unintentional injuries, crime and violence, risky sexual behaviours and sexual violence and blood-borne infections. Non-health-related problems included air rage, deportation and violation of local laws.

Conclusion
Substance abuse among international travellers is an underestimated problem that requires intervention. These findings emphasize the importance of addressing this issue to mitigate both health and well-being problems among travellers whilst promoting safer and more responsible travel experiences. In the context of travel health practices, practitioners should counsel travellers whose itineraries may include substance abuse, informing them about associated risks and consequences.
Deep cutaneous mycoses in kidney transplant recipients: Diagnostic and therapeutic challenges
Authors: Bertin Chloé , Sitterlé Emilie , Scemla Anne , Fraitag Sylvie , Delliere Sarah , Guegan Sarah , Hermoso Dea Garcia , Leclerc-Mercier Stéphanie , Rouzaud Claire , Lanternier Fanny , Bougnoux Marie-Elisabeth 
Published: January 2024

Abstract
Deep cutaneous mycoses (DCMs) are rare infections that extend throughout the dermis and subcutis, often occurring after inoculation with pathogenic fungi. Trends toward a growing incidence have been observed that may be partially related to an increasing population of solid organ transplant patients. The aim of this study is to describe the diagnostics and the outcomes of DCM among kidney transplant recipients so as to optimize their management. We performed a retrospective review of cases of DCM occurring among kidney transplant recipients in our institution over 12 years. Twenty cases were included. Lesions were only located on the limbs and presented mainly as single (10/20, 50%) nodular lesions (15/20, 75%), with a mean size of 3 cm. Direct mycological examination was positive for 17 patients (17/20, 85%) and the cultures were consistently positive. Thirteen different fungal species were observed, including phaehyphomycetes (n = 8), hyalohyphomycetes (n = 3), dermatophytes (n = 1), and mucorale (n = 1). The (1-3) beta-D-glucan antigen (BDG) was also consistently detected in the serum (20/20, 100%). Systematic imaging did not reveal any distant infectious lesions, but locoregional extension was present in 11 patients (11/14, 79%). Nineteen patients received antifungal treatment (19/20, 95%) for a median duration of 3 months, with surgery for 10 (10/20, 50%). There is a great diversity of fungal species responsible for DCMs in kidney transplant recipients. The mycological documentation is necessary to adapt the antifungal treatment according to the sensitivity of the species. Serum BDG positivity is a potentially reliable and useful tool for diagnosis and follow-up.
Impact of PSF misestimation and galaxy population bias on precision shear measurement using a CNN
Authors: Voigt L M 
Published: January 2024

ABSTRACT
Weak gravitational lensing of distant galaxies provides a powerful probe of dark energy. The aim of this study is to investigate the application of convolutional neural networks (CNNs) to precision shear estimation. In particular, using a shallow CNN, we explore the impact of point spread function (PSF) misestimation and ‘galaxy population bias’ (including ‘distribution bias’ and ‘morphology bias’), focusing on the accuracy requirements of next generation surveys. We simulate a population of noisy disc and elliptical galaxies and adopt a PSF that is representative of a Euclid-like survey. We quantify the accuracy achieved by the CNN, assuming a linear relationship between the estimated and true shears and measure the multiplicative (m) and additive (c) biases. We make use of an unconventional loss function to mitigate the effects of noise bias and measure m and c when we use either: (i) an incorrect galaxy ellipticity distribution or size–magnitude relation, or the wrong ratio of morphological types, to describe the population of galaxies (distribution bias); (ii) an incorrect galaxy light profile (morphology bias); or (iii) a PSF with size or ellipticity offset from its true value (PSF misestimation). We compare our results to the Euclid requirements on the knowledge of the PSF model shape and size. Finally, we outline further work to build on the promising potential of CNNs in precision shear estimation.
Assessing mass-loss and stellar-to-halo mass ratio of satellite galaxies: a galaxy–galaxy lensing approach utilizing DECaLS DR8 data
Authors: Wang Chunxiang , Li Ran , Shan Huanyuan , Xu Weiwei , Yao Ji , Jing Yingjie , Gao Liang , Li Nan , Xie Yushan , Zhu Kai , Yang Hang , Chen Qingze 
Published: January 2024

ABSTRACT
The galaxy–galaxy lensing technique allows us to measure the subhalo mass of satellite galaxies, studying their mass-loss and evolution within galaxy clusters and providing direct observational validation for theories of galaxy formation. In this study, we use the weak gravitational lensing observations from Dark Energy Spectroscopic Instrument (DESI) Legacy Imaging Surveys DR8, in combination with the redMaPPer galaxy cluster catalogue from Sloan Digital Sky Survey (SDSS) DR8 to accurately measure the dark matter halo mass of satellite galaxies. We confirm a significant increase in the stellar-to-halo mass ratio of satellite galaxies with their halo-centric radius, indicating clear evidence of mass-loss due to tidal stripping. Additionally, we find that this mass-loss is strongly dependent on the mass of the satellite galaxies, with satellite galaxies above $10^{11}~{{\rm M}_{\odot }}\, h^{-1}$ experiencing more pronounced mass-loss compared to lower mass satellites, reaching 86 per cent at projected halo-centric radius 0.5R200c. The average mass-loss rate, when not considering halo-centric radius, displays a U-shaped variation with stellar mass, with galaxies of approximately $4\times 10^{10}~{{\rm M}_{\odot }}\, h^{-1}$ exhibiting the least mass-loss, around 60 per cent. We compare our results with state-of-the-art hydrodynamical numerical simulations and find that the satellite galaxy stellar-to-halo mass ratio in the outskirts of galaxy clusters is higher compared to the predictions of the Illustris-TNG project about factor 5. Furthermore, the Illustris-TNG project’s numerical simulations did not predict the observed dependence of satellite galaxy mass-loss rate on satellite galaxy mass.
The self-organized criticality behaviours of two new parameters in SGR J1935+2154
Authors: Xiao Shuo , Zhang Shuang-Nan , Xiong Shao-Lin , Wang Ping , Li Xiu-Juan , Dong Ai-Jun , Zhi Qi-Jun , Li Di 
Published: January 2024

ABSTRACT
The minimum variation time-scale (MVT) and spectral lag of hundreds of X-ray bursts (XRBs) from soft gamma-ray repeater (SGR) J1935+2154 were analysed in detail for the first time in our recent work, which are important probes for studying the physical mechanism and radiation region. In this work, we investigate their differential and cumulative distributions carefully and find that they follow power-law models. Besides, the distributions of fluctuations in both parameters follow the Tsallis q-Gaussian distributions and the q values are consistent for different scale intervals. Therefore, these results indicate that both parameters are scale-invariant, which provides new parameters for the study of self-organized criticality systems. Interestingly, we find that the q values for MVT and spectral lag are similar with duration and fluence, respectively.
Angular complexity in strong lens substructure detection
Authors: O’Riordan Conor M , Vegetti Simona 
Published: January 2024

ABSTRACT
Strong gravitational lensing can be used to find otherwise invisible dark matter subhaloes. In such an analysis, the lens galaxy mass model is a significant source of systematic uncertainty. In this paper, we analyse the effect of angular complexity in the lens model. We use multipole perturbations that introduce low-order deviations from pure ellipticity in the isodensity contours, keeping the radial density profile fixed. We find that, in Hubble Space Telescope-like data, multipole perturbations consistent with those seen in galaxy isophotes are very effective at causing false positive substructure detections. We show that the effectiveness of this degeneracy depends on the deviation from a pure ellipse and the lensing configuration. We find that, when multipoles of 1 per cent are allowed in the lens model, the area in the observation where a subhalo could be detected drops by a factor of 3. Sensitivity away from the lensed images is mostly lost. However, the mass limit of detectable objects on or close to the lensed images does not change. We do not expect the addition of multipole perturbations to lens models to have a significant effect on the ability of strong lensing to constrain the underlying dark matter model. However, given the high rate of false positive detections, angular complexity beyond the elliptical power law should be included for such studies to be reliable. We discuss implications for previous detections and future work.
Spectroscopic diagnostic of the footpoints of the cool loops
Authors: Babu B Suresh , Kayshap Pradeep , Tripathi Sharad C , Jelínek P , Dwivedi B N 
Published: January 2024

ABSTRACT
Statistically, the cool loop’s footpoints are diagnosed using Si iv resonance lines observations provided by Interface Region Imaging Spectrograph (IRIS). The intensity and full width at half-maximum (FWHM) of the loop’s footpoints in β–γ active regions (ARs) are higher than the corresponding parameters of footpoints in β ARs. However, the Doppler velocity of footpoints in both ARs are almost similar to each other. The intensities of footpoints from β–γ AR is found to be around nine times that of β AR when both ARs are observed nearly at the same time. The same intensity difference reduces nearly to half (four times) when considering all ARs observed over 9 yr. Hence, the instrument degradation affects comparative intensity analysis. We find that Doppler velocity and FWHM are well correlated while peak intensity is neither correlated with Doppler velocity nor FWHM. The loop’s footpoints in β–γ ARs have around four times more complex Si iv spectral profiles than that of β ARs. The intensity ratios (Si iv 1393.78 Å/1402.77 Å) of the significant locations of footpoints differ, marginally, (i.e. either less than 1.9 or greater than 2.10) from the theoretical ratio of 2, i.e. 52 per cent (55 per cent) locations in β (β–γ) ARs significantly deviate from 2. Hence, we say that more than half of the footpoint locations are either affected by the opacity or resonance scattering. We conclude that the nature and attributes of the footpoints of the cool loops in β–γ ARs are significantly different from those in β ARs.