bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum 25(OH)D levels are associated with disease activity and renal involvement in initial-onset childhood systemic lupus erythematosus
Authors: Jiang Lijun , Zhi Shufeng , Wei Chenxi , Rong Zanhua , Zhang Huifeng 
Published: December 2023

BackgroundVitamin D deficiency is common in patients with systemic lupus erythematosus (SLE) and may affect their disease activity and severity.ObjectiveThis study aims to assess the vitamin D status in patients with initial-onset SLE during childhood and its association with the clinical and laboratory markers of disease activity.MethodThis is a retrospective study that includes 168 patients with initial-onset SLE during childhood and 109 healthy children as controls. Clinical and laboratory data were recorded. The area under the curve (AUC) method was used to evaluate the efficacy of double-stranded deoxyribonucleic acid (dsDNA), lower 25(OH)D and complement 3 (C3) alone and in combination to diagnose the presence of renal damage in children with SLE.ResultCompared with the controls (25.53 ± 7.02 ng/ml), patients with initial-onset SLE during childhood have lower serum 25(OH)D levels (18.63 ± 5.32 ng/ml) (P &lt; 0.05). Among patients with initial-onset SLE during childhood, SLEDAI-2K scores are significantly higher in the vitamin D insufficiency (median = 14.5) and vitamin D deficiency (median = 14.0) groups than in the vitamin D sufficiency group (median = 9.0) (P &lt; 0.05). Patients with initial-onset SLE during childhood with lower 25(OH)D levels are more likely to have lupus nephritis (LN) and a higher SDI score (P &lt; 0.05). Compared with patients with other types of LN (16.69 ± 3.90 ng/ml), patients with type V LN have lower levels of 25(OH)D (12.27 ± 3.53 ng/ml) (P &lt; 0.05). The AUC was 0.803 when dsDNA antibody, 25(OH)D level and C3 were used in combination to diagnose LN in patients with SLE.ConclusionVitamin D deficiency and insufficiency are closely related to an increase in SLEDAI and SDI scores. Significant decrease in vitamin D level is a risk factor for LN.
An exploratory study on counterfactual thinking in amyotrophic lateral sclerosis
Authors: Poletti Barbara , Aiello Edoardo Nicolò , Tagini Sofia , Solca Federica , Torre Silvia , Colombo Eleonora , Maranzano Alessio , Bonetti Ruggero , Schevegher Francesco , Morelli Claudia , Doretti Alberto , Verde Federico , Barbieri Sergio , Mameli Francesca , Priori Alberto , Ferrucci Roberta , Silani Vincenzo , Cherubini Paolo , Pravettoni Gabriella , Ticozzi Nicola 
Published: December 2023

ObjectivesThis study aimed at exploring (1) the motor and non-motor correlates of counterfactual thinking (CFT) abilities in non-demented amyotrophic lateral sclerosis (ALS) patients and (2) the ability of CFT measures to discriminate these patients from healthy controls (HCs) and patients with and without cognitive impairment.MethodsN = 110 ALS patients and N = 51 HCs were administered two CFT tasks, whose sum, resulting in a CFT Index (CFTI), was addressed as the outcome. Patients further underwent an in-depth cognitive, behavioral, and motor-functional evaluation. Correlational analyses were run to explore the correlates of the CFTI in patients. Logistic regressions were performed to test whether the CFTI could discriminate patients from HCs.ResultsThe CFTI was selectively associated (p ≤ 0.005) with fluency and memory subscales of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS), but not with other variables. CFTI scores discriminated patients from HCs (p &lt; 0.001) with high accuracy (82%), but not patients with a normal vs. defective performance on the ECAS-Total.ConclusionCFT measures in non-demented ALS patients were associated with verbal fluency and memory functions, and they were also able to discriminate them from HCs.
Positive psychosocial factors and the development of symptoms of depression and posttraumatic stress symptoms following acute myocardial infarction
Authors: Zuccarella-Hackl Claudia , Jimenez-Gonzalo Lucia , von Känel Roland , Princip Mary , Jellestad Lena , Langraf-Meister Rebecca E. , Znoj Hansjörg , Schmid Jean-Paul , Barth Jürgen , Schnyder Ulrich , Ledermann Katharina 
Published: December 2023

IntroductionAcute myocardial infarction (MI) is a potentially fatal condition, leading to high psychological distress and possibly resulting in the development of depressive symptoms and posttraumatic stress symptoms (PTSS). The aim of this study was to investigate the association of clusters of positive psychosocial factors (resilience, task-oriented coping, positive affect and social support) with both MI-induced depressive symptoms and PTSS, independent of demographic factors.MethodsWe investigated 154 consecutive patients with MI, 3 and 12 months after hospital discharge. All patients completed the short version of the German Resilience Scale, the Coping Inventory for Stressful Situations (CISS), the Enriched Social Support Inventory (ESSI) and the Global Mood Scale (GMS). The level of interviewer-rated MI-induced posttraumatic stress disorder (PTSD) symptoms at 3- and 12-months follow-up was evaluated through the Clinician-Administered PTSD Scale (CAPS). Depressive symptoms were assessed at 3- and 12-month follow-up with the Beck Depression Inventory (BDI-II).ResultsThree different clusters were revealed: (1) lonely cluster: lowest social support, resilience and average task-oriented coping and positive affect; (2) low risk cluster: highest resilience, task-oriented coping, positive affect and social support; (3) avoidant cluster: lowest task-oriented coping, positive affect, average resilience and social support. The clusters differed in depressive symptoms at 3 months (F = 5.10; p &lt; 0.01) and 12 months follow-up (F = 7.56; p &lt; 0.01). Cluster differences in PTSS were significant at 3 months (F = 4.78, p &lt; 0.05) and 12 months (F = 5.57, p &lt; 0.01) follow-up. Differences in PTSS subscales were found for avoidance (F = 4.8, p &lt; 0.05) and hyperarousal (F = 5.63, p &lt; 0.05), but not re-experiencing, at 3 months follow-up. At 12 months follow-up, cluster differences were significant for re-experiencing (F = 6.44, p &lt; 0.01) and avoidance (F = 4.02, p &lt; 0.05) but not hyperarousal.DiscussionThe present study contributes to a better understanding of the relationships among different positive psychosocial factors, depressive symptoms and PTSS following acute MI. Future interventions may benefit from taking into account positive psychosocial factors to potentially reduce patients’ depressive symptoms and PTSS after MI.
Model-agnostic explainable artificial intelligence tools for severity prediction and symptom analysis on Indian COVID-19 data
Authors: Nambiar Athira , S Harikrishnaa , S Sharanprasath 
Published: December 2023

IntroductionThe COVID-19 pandemic had a global impact and created an unprecedented emergency in healthcare and other related frontline sectors. Various Artificial-Intelligence-based models were developed to effectively manage medical resources and identify patients at high risk. However, many of these AI models were limited in their practical high-risk applicability due to their “black-box” nature, i.e., lack of interpretability of the model. To tackle this problem, Explainable Artificial Intelligence (XAI) was introduced, aiming to explore the “black box” behavior of machine learning models and offer definitive and interpretable evidence. XAI provides interpretable analysis in a human-compliant way, thus boosting our confidence in the successful implementation of AI systems in the wild.MethodsIn this regard, this study explores the use of model-agnostic XAI models, such as SHapley Additive exPlanations values (SHAP) and Local Interpretable Model-Agnostic Explanations (LIME), for COVID-19 symptom analysis in Indian patients toward a COVID severity prediction task. Various machine learning models such as Decision Tree Classifier, XGBoost Classifier, and Neural Network Classifier are leveraged to develop Machine Learning models.Results and discussionThe proposed XAI tools are found to augment the high performance of AI systems with human interpretable evidence and reasoning, as shown through the interpretation of various explainability plots. Our comparative analysis illustrates the significance of XAI tools and their impact within a healthcare context. The study suggests that SHAP and LIME analysis are promising methods for incorporating explainability in model development and can lead to better and more trustworthy ML models in the future.
Sexual, reproductive and mental health among young men (10–24) in low-and-middle income countries: a scoping review
Authors: Mhlongo Siphiwe , Mason-Jones Amanda J. , Ford Keith 
Published: December 2023

BackgroundThe relationship between SRH and mental health among men is not well documented, especially in the 10–24 age group. This scoping review aimed to investigate what is known about the association between SRH and mental health among young men (10–24) in LMICs.MethodsEmbase, APA PsycInfo, MEDLINE(R) ALL, ASSIA and the Cochrane Library of Database of Systematic Reviews were searched from the year of establishment up to August 2022. The review was reported using the PRISMA-ScR checklist.ResultsA total of (n = 2636) studies were identified from the five databases. After the completion of screening, only ten studies (n = 8 cross-sectional, n = 1 mixed methods and n = 1 qualitative) met the eligibility criteria and were included in the review. The findings suggest that there is a reciprocal relationship between mental health and SRH. Sperm concentration and total sperm count were found to be lower in depressed men. Poor mental health was associated with early sexual debut, higher rates of sexual activity and an increased number of sexual partners. Poor mental health was also found among men who had sex with men (MSM). In addition, we found a relationship between sexual abuse, sexual coercion and poor mental health.ConclusionThe findings of this unique study indicate that poor mental health is associated with poor SRH outcomes and vice versa among young men (10–24) living in LMICs. However, further research will be needed to establish the temporal relationship between SRH and mental health outcomes.
Research on water extraction from high resolution remote sensing images based on deep learning
Authors: Wu Peng , Fu Junjie , Yi Xiaomei , Wang Guoying , Mo Lufeng , Maponde Brian Tapiwanashe , Liang Hao , Tao Chunling , Ge WenYing , Jiang TengTeng , Ren Zhen 
Published: December 2023

Introduction: Monitoring surface water through the extraction of water bodies from high-resolution remote sensing images is of significant importance. With the advancements in deep learning, deep neural networks have been increasingly applied to high-resolution remote sensing image segmentation. However, conventional convolutional models face challenges in water body extraction, including issues like unclear water boundaries and a high number of training parameters.Methods: In this study, we employed the DeeplabV3+ network for water body extraction in high-resolution remote sensing images. However, the traditional DeeplabV3+ network exhibited limitations in segmentation accuracy for high-resolution remote sensing images and incurred high training costs due to a large number of parameters. To address these issues, we made several improvements to the traditional DeeplabV3+ network: Replaced the backbone network with MobileNetV2. Added a Channel Attention (CA) module to the MobileNetV2 feature extraction network. Introduced an Atrous Spatial Pyramid Pooling (ASPP) module. Implemented Focal loss for balanced loss computation.Results: Our proposed method yielded significant enhancements. It not only improved the segmentation accuracy of water bodies in high-resolution remote sensing images but also effectively reduced the number of network parameters and training time. Experimental results on the Water dataset demonstrated superior performance compared to other networks: Outperformed the U-Net network by 3.06% in terms of mean Intersection over Union (mIoU). Outperformed the MACU-Net network by 1.03%. Outperformed the traditional DeeplabV3+ network by 2.05%. The proposed method surpassed not only the traditional DeeplabV3+ but also U-Net, PSP-Net, and MACU-Net networks.Discussion: These results highlight the effectiveness of our modified DeeplabV3+ network with MobileNetV2 backbone, CA module, ASPP module, and Focal loss for water body extraction in high-resolution remote sensing images. The reduction in training time and parameters makes our approach a promising solution for accurate and efficient water body segmentation in remote sensing applications.
Forecasting individual exercise sweat losses from forecast air temperature and energy expenditure
Authors: Cheuvront Samuel N. , Sollanek Kurt J. , Kenefick Robert W. 
Published: December 2023

IntroductionRecent success in predicting individual sweat losses from air temperature and energy expenditure measurements suggests a potential for forecasting individual sweat losses for future combinations of environment and exercise. The purpose of this study is to determine the plausibility of accurately forecasting exercise sweat losses from meteorological air temperature forecasts and individual running energy expenditure forecasts. The potential impact on plasma sodium is also estimated when setting drinking rates equal to forecast sweat losses.Materials and methodsIndividual exercise sweat losses (equated to water needs) and energy expended while running were measured in 33 participants along with air temperature and compared with forecasts of the same. Forecast inputs were used in a web app to forecast exercise sweat losses for comparison with observed values. The bias between forecast and observed exercise sweat losses was used to calculate the potential drinking impact on plasma sodium.ResultsThe concordance correlation coefficient between forecast and observed values was 0.95, 0.96, and 0.91 for air temperature, energy expenditure, and exercise sweat losses, respectively, indicating excellent agreement and no significant differences observed via t-test. Perfect matching of water intake to sweat losses would lower plasma sodium concentrations from 140 to 138 mmol/L; calculations using the 95% limits of agreement for bias showed that drinking according to forecast exercise sweat losses would alter plasma sodium concentrations from 140 to between 136 and 141 mmol/L.ConclusionsThe outcomes support the strong potential for accurately forecasting exercise sweat losses from commonly available meteorological air temperature forecasts and energy expenditure from forecast running distance.
Tendencia genética en bovinos de aptitud cárnica en la hacienda La Victoria, provincia del Guayas
Authors: Larrea-Izurieta Carlos Octavio 
Published: December 2023

Se determinó las tendencias genéticas para peso al nacimiento (PN) y peso al destete ajustado a 205 días (PD) en hembras mestizas con base Brahman nacidas entre 2005 y 2021 en la hacienda “La Victoria”, cantón Bucay, provincia del Guayas. Se analizaron 946 animales con 351 registros para PN y 314 para PD generados entre 2011 y 2021. El modelo estadístico y animal incluyó efecto aleatorio de los padres y como efectos fijos: año de nacimiento y composición racial. Se aplicó el procedimiento del modelo lineal general (GLM) del paquete estadístico SAS para análisis de varianza. Los componentes de la varianza para calcular parámetros genéticos de PN y PD se utilizó el software VCE v.6 y para valores de cría se utilizó el software MTDFRELM, a través del sistema de evaluación del Mejor Predictor Lineal Insesgado. Se encontró promedio para PN de 37,64 ± 2,35 Kg y para PD de 195,09 ± 30,12 Kg. Se halló diferencia altamente significativa (p≤0,01) para los efectos aleatorios y fijos, la heredabilidad para PN fue de 0,137 ± 0,209 y para PD de 0,454 ± 0,177 y correlación genética de -0,181. La tendencia genética anual fue de 0,3055 Kg (R2 = 0,0633) para PN y 0,5879 Kg (R2 = 0,0491) para PD. Se concluye que la baja heredabilidad de PN se encuentra influenciada por factores no genéticos y alta heredabilidad encontrada para PD tiene mayor influencia genética aditiva; aun así, las tendencias genéticas para ambos caracteres fueron cercanas a cero y no muestran progreso genético.
À propos de la contribution des enlumineurs dans la Bible de Petr Zmrzlík de Svojšín
Authors: Brodsky Pavel , Šumová Martina 
Published: December 2023

Several masters of different levels participated in the decoration of the three volumes of the Bible of the Mint Master Petr Zmrzlík of Svojšín (1411-1414), the oldest
preserved copy of the full text of the first edition of the Bible translated into Czech -after the disappearance of the Dresden Bible. Previous studies did not sufficiently
consider the different levels of decoration that are similar to the “ Beau Style” (Schöner Stil) and it is to the contribution of Markéta Pražáková that we owe a change of perspective on the quality of the illuminations. If we can agree that the painter, who until now was called Zmrzlík’s Master of the Bible, was the main illuminator (the Master of the Book of Psalms), we can identify several hands under the term workshop of the Master of the Book of Psalms. The article refines certain propositions made by Markéta Pražáková and proposes other identifications-for example, for the miniatures attributed to the Master of the Prophecy of Joel : the Master of the Mandeville Travels can be considered as the
author of three of them, the others were executed by the Master of the Antwerp Bible. Finally, we must rethink the identification of the illuminator called the Master of the Book of Esther. In fact, his style shows that this is, once more, the work of the Master of the Antwerp Bible.
ONTOLOGY OF QUALITY ENGINEERING FOR THE DEVELOPMENT OF DOCUMENT EXCHANGE FUNCTIONAL SERVICE PROGRAMS
Authors: Соболь В.М. , Коротаев В.Б. 
Published: December 2023

Рассматриваются основные аспекты методологии создания, контроля и модернизации телекоммуникационных устройств электросвязи специализированной системы обмена документальной информацией. Изложены элементы информационного обеспечения (инфосферы) ряда нормативных материалов – фрагменты технического задания и тактикотактических характеристик, внутрисистемные протоколы, формализмы спецификации программ, описан инструментарий отладки и сопровождения, регламентирующие функциональную полноту проекта интегрированной гетерогенной системы документального обмена.
The main aspects of the methodology for creating, monitoring and upgrading telecommunication devices of a specialized system for the exchange of documentary information are considered. The elements of information support (infosphere) of a number of normative materials are set out - fragments of technical specifications and tactical characteristics, intra-system protocols, formalisms of program specifications, debugging and maintenance tools are described, regulating the functional completeness of the project of an integrated heterogeneous system of documentary exchange.
Botulinotherapy of Neurological Disorders in Children with Klippel-Feil Syndrome: A Case Report
Authors: Яковлев А.Н. , Шалькевич Л.В. , Чернуха Т.Н. , Сташков А.К. , Мелюкова А.А. , Гаманицкая М.В. , Гирис К.О. 
Published: December 2023

Синдром Клиппеля – Фейля (СКФ) представляет собой врожденный порок развития позвоночника (преимущественно шейных и верхнегрудных позвонков) в виде их аномального сращения, нарушения деления или физиологической сегментации. Развитие синдрома Клиппеля – Фейля преимущественно ассоциировано с генетическими мутациями в следующих генах: GDF6, GDF3, MEOX1, MYO18B, RIPPLY2, BAZ1B, FREM2, SUFU, VANGL1, KMT2D. Клинически синдром проявляется мультисистемной патологией, среди которой ведущие симптомы представлены неврологическими нарушениями. В статье приводится опыт off-lable-терапии ботулиническим токсином типа А рефлекторно-тонического и болевого синдромов у ребенка вследствие СКФ. Проведенная ботулинотерапия в раннем постинъекционном периоде привела к оптимизации мышечного тонуса мышц-мишеней – musculus trapezius и musculus levator scapulae с обеих сторон, увеличению активных и пассивных движений головы, снижению выраженности болевого синдрома. Таким образом, ботулинотерапия при СКФ может использоваться для повышения качества жизни пациентов, профилактики соединительнотканного перерождения вовлеченных в патологический процесс мышц, может позволить отсрочить оперативное вмешательство или избежать его использования.
Klippel-Feil syndrome is a congenital malformation of the spine (mainly the cervical and upper thoracic vertebrae), in the form of their abnormal fusion, division disorders or physiological segmentation. Emergence of KFS is mostly associated with genetic mutations in following genes: GDF6, GDF3, MEOX1, MYO18B, RIPPLY2, BAZ1B, FREM2, SUFU, VANGL1, KMT2D. Clinically, the syndrome is manifested by multisystem pathology in which the leading symptoms belong to neurological disorders. The article presents the experience of off-lable therapy with botulinum toxin type A (BTA) reflex-tonic and pain syndrome in a child due to KFS. The botulinum toxin therapy performed in the early post-injection period led to the optimization of the muscle tone of the target muscles: musculus trapezius and musculus levator scapulae on both sides, an increase in active and passive head movements, and a decrease in the severity of pain syndrome. Therefore, botulinum toxin therapy in the case of KFS can be used for increasing patient life quality, prevention of connective tissue muscles degeneration and can allow to delay or avoid surgery.
Le corps des bio-artistes : de la fiction à la réalité
Authors: Voison Catherine 
Published: December 2023

Aujourd’hui, de nouvelles pratiques artistiques intègrent des techniques scientifiques liées à la recherche médicale modifiant in vivo les performances biologiques du corps, le transformant en un singulier objet de laboratoire. Ainsi, certains artistes font œuvre de leurs corps en le soumettant à diverses procédures biotechnologiques le plus souvent invasives. Augmenté, le corps biologique de ces artistes-performeurs devient un lieu d’expérimentation. Adeptes du DIY (Do It Yourself) ou accompagnés de biologistes et de médecins, ces « bio-artistes » sont-ils les témoins des changements d’une nouvelle mécanisation du corps humain dont nous commençons à peine à prendre connaissance et dont nous n’avons pas encore mesuré toute la complexité ? Pourrait-il exister, au nom de l’art, des raisons qui justifient la mise en œuvre de corps utopiques, non eschatologiques, et susceptibles de nous faire croire au pire ou au meilleur des mondes ? En prenant appui sur les performances de Stelarc, de Yann Marussich, de Marion Laval-Jeantet et du duo Quimera Rosa, notre propos vise à analyser les enjeux de cette nouvelle fabrique du corps hors de ses limites biologiques.