bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chern-Simons theory, Ehrhart polynomials, and representation theory
Authors: Ju Chao 
Published: January 2024

Abstract
The Hilbert space of level q Chern-Simons theory of gauge group G of the ADE type quantized on T2 can be represented by points that lie on the weight lattice of the Lie algebra g up to some discrete identifications. Of special significance are the points that also lie on the root lattice. The generating functions that count the number of such points are quasi-periodic Ehrhart polynomials which coincide with the generating functions of SU(q) representation of the ADE subgroups of SU(2) given by the McKay correspondence. This coincidence has roots in a string/M theory construction where D3(M5)-branes are put along an ADE singularity. Finally, a new perspective on the McKay correspondence that involves the inverse of the Cartan matrices is proposed.
Direct enhancement of viral neutralising antibody potency by the complement system: a largely forgotten phenomenon
Authors: Mellors Jack , Carroll Miles 
Published: January 2024

AbstractNeutralisation assays are commonly used to assess vaccine-induced and naturally acquired immune responses; identify correlates of protection; and inform important decisions on the screening, development, and use of therapeutic antibodies. Neutralisation assays are useful tools that provide the gold standard for measuring the potency of neutralising antibodies, but they are not without limitations. Common methods such as the heat-inactivation of plasma samples prior to neutralisation assays, or the use of anticoagulants such as EDTA for blood collection, can inactivate the complement system. Even in non-heat-inactivated samples, the levels of complement activity can vary between samples. This can significantly impact the conclusions regarding neutralising antibody potency. Restoration of the complement system in these samples can be achieved using an exogenous source of plasma with preserved complement activity or with purified complement proteins. This can significantly enhance the neutralisation titres for some antibodies depending on characteristics such as antibody isotype and the epitope they bind, enable neutralisation with otherwise non-neutralising antibodies, and demonstrate a better relationship between in vitro and in vivo findings. In this review, we discuss the evidence for complement-mediated enhancement of antibody neutralisation against a range of viruses, explore the potential mechanisms which underpin this enhancement, highlight current gaps in the literature, and provide a brief summary of considerations for adopting this approach in future research applications.
Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT
Authors: Varga Elisabeth , Prause Hélène-Christine , Riepl Matthias , Hochmayr Nadine , Berk Deniz , Attakpah Eva , Kiss Endre , Medić Nikola , Del Favero Giorgia , Larsen Thomas Ostenfeld , Hansen Per Juel , Marko Doris 
Published: January 2024

AbstractHarmful algal blooms kill fish populations worldwide, as exemplified by the haptophyte microalga Prymnesium parvum. The suspected causative agents are prymnesins, categorized as A-, B-, and C-types based on backbone carbon atoms. Impacts of P. parvum extracts and purified prymnesins were tested on the epithelial rainbow trout fish gill cell line RTgill-W1 and on the human colon epithelial cells HCEC-1CT. Cytotoxic potencies ranked A > C > B-type with concentrations spanning from low (A- and C-type) to middle (B-type) nM ranges. Although RTgill-W1 cells were about twofold more sensitive than HCEC-1CT, the cytotoxicity of prymnesins is not limited to fish gills. Both cell lines responded rapidly to prymnesins; with EC50 values for B-types in RTgill-W1 cells of 110 ± 11 nM and 41.5 ± 0.6 nM after incubations times of 3 and 24 h. Results of fluorescence imaging and measured lytic effects suggest plasma membrane interactions. Postulating an osmotic imbalance as mechanisms of toxicity, incubations with prymnesins in media lacking either Cl−, Na+, or Ca2+ were performed. Cl− removal reduced morphometric rearrangements observed in RTgill-W1 and cytotoxicity in HCEC-1CT cells. Ca2+-free medium in RTgill-W1 cells exacerbated effects on the cell nuclei. Prymnesin composition of different P. parvum strains showed that analog composition within one type scarcely influenced the cytotoxic potential, while analog type potentially dictate potency. Overall, A-type prymnesins were the most potent ones in both cell lines followed by the C-types, and lastly B-types. Disturbance of Ca2+ and Cl− ionoregulation may be integral to prymnesin toxicity.
Value of MR arthrography for evaluation of children and adolescents with clinically suspected intraarticular cause of hip pain
Authors: Schmitt Laura , Pfirrmann Christian W. A. , Buck Florian M. , Hany Thomas F. , Rosskopf Andrea B. 
Published: January 2024

Abstract
Purpose
To evaluate the distribution of intra- and extraarticular MRI findings in children and adolescents with clinically suspected intraarticular cause of hip pain in order to assess the need for additional intraarticular contrast administration.

Material and methods
Database was searched over a period of 34 months retrospectively for consecutive hip MR arthrography in young patients (8–17 years) with suspected intraarticular cause of hip or groin pain. Exclusion criteria were prior hip surgery, follow-up examination due to known intraarticular pathology, incomplete examination, qualitatively non-diagnostic examinations, and missing informed consent. Reports of fellowship-trained MSK radiologists were searched for intraarticular versus extraarticular findings explaining hip or groin pain.

Results
Seventy patients (68% female; median age: 14.5 years; range:10.8–16.9 years) were analyzed. No reason for pain was found in 30 (42.9%) hips, extraarticular reasons in 20 (28.6%) cases, intraarticular in 14 (20.0%), and both (intra- and extraarticular) in 6 (8.6%) hips. Most common extraarticular reasons were apophysitis (14.3%), other bony stress reactions (12.9%), intramuscular edema (7%), tendinitis (5.7%), and trochanteric bursitis (4.3%). Labral pathology was the most common intraarticular finding (overall:34.3%; partial tear:15.7%, complete tear:15.7%), most frequent at the anterosuperior position (81.8%). Cartilage defects (1.4%), intraarticular neoplasia (1.4%), and tear of the femoral head ligament (2.8%) were rarely found. Synovitis and loose bodies were not observed. Cam-(37.1%) and pincer-configurations (47.1%) were common while hip dysplasia was rare (5.7%).

Conclusion
MRI in children and adolescents with hip pain should be done primarily without intraarticular contrast administration since most cases show an extraarticular pain reason or no diagnosis detectable with MRI.
LsMybW-encoding R2R3-MYB transcription factor is responsible for a shift from black to white in lettuce seed
Authors: Seki Kousuke , Komatsu Kenji , Yamaguchi Kanami , Murai Yoshinori , Nishida Keiji , Koyama Ryohei , Uno Yuichi 
Published: January 2024

Abstract
Key message
We identified LsMybW as the allele responsible for the shift in color from black to white seeds in wild ancestors of lettuce to modern cultivars.

Abstract
Successfully selected white seeds are a key agronomic trait for lettuce cultivation and breeding; however, the mechanism underlying the shift from black—in its wild ancestor—to white seeds remains uncertain. We aimed to identify the gene/s responsible for white seed trait in lettuce. White seeds accumulated less proanthocyanidins than black seeds, similar to the phenotype observed in Arabidopsis TT2 mutants. Genetic mapping of a candidate gene was performed with double-digest RAD sequencing using an F2 population derived from a cross between “ShinanoPower” (white) and “Escort” (black). The white seed trait was controlled by a single recessive locus (48.055–50.197 Mbp) in linkage group 7. Using five PCR-based markers and numerous cultivars, eight candidate genes were mapped in the locus. Only the LG7_v8_49.251Mbp_HinfI marker, employing a single-nucleotide mutation in the stop codon of Lsat_1_v5_gn_7_35020.1, was completely linked to seed color phenotype. In addition, the coding region sequences for other candidate genes were identical in the resequence analysis of “ShinanoPower” and “Escort.” Therefore, we proposed Lsat_1_v5_gn_7_35020.1 as the candidate gene and designated it as LsMybW (Lactuca sativaMyb White seeds), an ortholog encoding the R2R3-MYB transcription factor in Arabidopsis. When we validated the role of LsMybW through genome editing, LsMybW knockout mutants harboring an early termination codon showed a change in seed color from black to white. Therefore, LsMybW was the allele responsible for the shift in seed color. The development of a robust marker for marker-assisted selection and identification of the gene responsible for white seeds have implications for future breeding technology and physiological analysis.
Perceptions of radiologists on structured reporting for cancer imaging—a survey by the European Society of Oncologic Imaging (ESOI)
Authors: Leithner Doris , Sala Evis , Neri Emanuele , Schlemmer Heinz-Peter , D’Anastasi Melvin , Weber Michael , Avesani Giacomo , Caglic Iztok , Caruso Damiano , Gabelloni Michela , Goh Vicky , Granata Vincenza , Kunz Wolfgang G. , Nougaret Stephanie , Russo Luca , Woitek Ramona , Mayerhoefer Marius E. 
Published: January 2024

Abstract
Objectives
To assess radiologists’ current use of, and opinions on, structured reporting (SR) in oncologic imaging, and to provide recommendations for a structured report template.

Materials and methods
An online survey with 28 questions was sent to European Society of Oncologic Imaging (ESOI) members. The questionnaire had four main parts: (1) participant information, e.g., country, workplace, experience, and current SR use; (2) SR design, e.g., numbers of sections and fields, and template use; (3) clinical impact of SR, e.g., on report quality and length, workload, and communication with clinicians; and (4) preferences for an oncology-focused structured CT report. Data analysis comprised descriptive statistics, chi-square tests, and Spearman correlation coefficients.

Results
A total of 200 radiologists from 51 countries completed the survey: 57.0% currently utilized SR (57%), with a lower proportion within than outside of Europe (51.0 vs. 72.7%; p = 0.006). Among SR users, the majority observed markedly increased report quality (62.3%) and easier comparison to previous exams (53.5%), a slightly lower error rate (50.9%), and fewer calls/emails by clinicians (78.9%) due to SR. The perceived impact of SR on communication with clinicians (i.e., frequency of calls/emails) differed with radiologists’ experience (p < 0.001), and experience also showed low but significant correlations with communication with clinicians (r = − 0.27, p = 0.003), report quality (r = 0.19, p = 0.043), and error rate (r = − 0.22, p = 0.016). Template use also affected the perceived impact of SR on report quality (p = 0.036).

Conclusion
Radiologists regard SR in oncologic imaging favorably, with perceived positive effects on report quality, error rate, comparison of serial exams, and communication with clinicians.

Clinical relevance statement
Radiologists believe that structured reporting in oncologic imaging improves report quality, decreases the error rate, and enables better communication with clinicians. Implementation of structured reporting in Europe is currently below the international level and needs society endorsement.

Key Points
• The majority of oncologic imaging specialists (57% overall; 51% in Europe) use structured reporting in clinical practice.
• The vast majority of oncologic imaging specialists use templates (92.1%), which are typically cancer-specific (76.2%).
• Structured reporting is perceived to markedly improve report quality, communication with clinicians, and comparison to prior scans.
How does warmer sea water change the sensitivity of a Mediterranean thermophilic coral after immune-stimulation?
Authors: Bisanti L. , La Corte C. , Dara M. , Bertini F. , Parrinello D. , Chemello R. , Cammarata M. , Parisi M. G. 
Published: January 2024

AbstractAnthropogenic climate change is warming sea water worldwide, pushing the limits of tolerance for marine organisms and driving a decline in biodiversity. The risk of thermal anomalies has increased particularly in the Mediterranean region over the last 30 yrs, where intense warming has been identified as one of the main stressors in coastal regions. To determine the influence of warmer conditions on the immunity of an endemic Mediterranean coral species, different immune activity parameters were compared in response to elevated temperature (~ 28 °C) and the presence of a pathogen-associated molecular pattern—Escherichia coli lipopolysaccharide (LPS)—as an elicitor of the innate immune response of Astroides calycularis. Immune parameters, which included phenoloxidase-like, glutathione peroxidase, lysozyme-like, alkaline phosphatase, and esterase enzyme activity, were measured over time after LPS balneation (0-, 12-, 48-, and 120 h time point). All five enzymes demonstrated constant values under environmental conditions (~ 23 °C), indicating a constituent activity. LPS at environmental temperature induced significant upregulation immediately after exposure (0 h-time point), demonstrating an immune response to the pathogen elicitor. Under warmer conditions (~ 28 °C), constituent values increased over time, indicating a shift in the immune strategy to maintain homeostasis. However, warmer sea water, within the summer range experienced by this coral species, impaired the immune response to LPS, delaying it over time. These changes in immune strategy indicate that temperature affects coral immunity and, in thermophilic A. calycularis, results in an energy trade-off that could maintain its health-state through suboptimal conditions during multiple perturbations, such as summertime diseases.
Health-related quality of life across disease stages in patients with amyotrophic lateral sclerosis: results from a real-world survey
Authors: Stenson Katie , Fecteau T. E. , O’Callaghan L. , Bryden P. , Mellor J. , Wright J. , Earl L. , Thomas O. , Iqbal H. , Barlow S. , Parvanta S. 
Published: January 2024

AbstractBackgroundAmyotrophic lateral sclerosis (ALS) is characterized by a rapid disease course, with disease severity being associated with declining health-related quality of life (HRQoL) in persons living with ALS (pALS). The main objective of this study was to assess the impact of disease progression on HRQoL across King’s, Milano-Torino Staging (MiToS), and physician-judgement clinical staging. Additionally, we evaluated the impact of the disease on the HRQoL of care partners (cALS).MethodsData were sourced from the Adelphi ALS Disease Specific Programme (DSP)™, a cross-sectional survey of neurologists, pALS and cALS presenting in a real-world clinical setting between July 2020 and March 2021 in Europe and the United States.ResultsNeurologists (n = 142) provided data for 880 pALS. There were significant negative correlations between all three clinical staging systems and EuroQol (European Quality of Life) Five Dimension Five Level Scale (EQ-5D-5L) utility scores and visual analogue scale (VAS) ratings. Although not all differences were significant, 5-item Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-5) scores showed a stepwise increase in HRQoL impairment at each stage of the disease regardless of the staging system. At later stages, high levels of fatigue and substantial activity impairment were reported. As pALS disease states progressed, cALS also experienced a decline in HRQoL and increased burden.ConclusionsAcross outcomes, pALS and cALS generally reported worse outcomes at later stages of the disease, highlighting an unmet need in this population for strategies to maximise QoL despite disease progression. Recognition and treatment of symptoms such as pain and fatigue may lead to improved outcomes for pALS and cALS.
When time does not matter: cultures differ in their use of temporal cues to infer agency over action effects
Authors: Bart Victoria K. E. , Sharavdorj Erdenechimeg , Boldbaatar Enerel , Bazarvaani Khishignyam , Rieger Martina 
Published: January 2024

AbstractSense of agency (SoA) is the sense of having control over one’s own actions and through them events in the outside world. Sometimes temporal cues, that is temporal contiguity between action and effect, or temporal expectation regarding the occurrence of the effect are used to infer whether one has agency over an effect. This has mainly been investigated in Western cultures. However, Western and Eastern cultures differ in their time concepts and thus their usage of temporal cues may also differ. We investigated whether Western and Eastern cultures (Austrian vs. Mongolian students) use temporal cues differently. Participants performed adaption blocks in which actions were followed by immediate (immediate effect group) or by delayed (delayed effect group) effects. In subsequent test blocks the action–effect delay was varied and participants’ SoA over the effect was assessed. In Austrian students, the immediate effect group experienced more SoA for short action–effect delays, whereas the reverse was true for the delayed effect group. Thus, temporal expectation rather than temporal contiguity is used as predominant agency cue. In Mongolian students, SoA did not significantly differ between different action–effect delays in both groups, indicating that Mongolian students hardly rely on temporal cues. In conclusion, due to linear time concepts in Western cultures, the timing of an effect may be an important agency cue in Austrian students. However, due to cyclical time concepts in some Eastern cultures, it may be a less important agency cue in Mongolian students. Thus, the use of temporal agency cues is culture-dependent.
Incidence and risk factors for febrile neutropenia of patients with diffuse large B-cell lymphoma receiving R-CHOP-21 in China
Authors: Zheng Wenshuai , Chen Zhaoguang , Zhu Shibin , Cheng Longcan , Hu Yalei , Yang Yuhui , Tan Min , Ning Hongmei , Guan Lixun 
Published: January 2024

Abstract
Objective
Febrile neutropenia (FN) is a serious complication of patients with diffuse large B-cell lymphoma (DLBCL) receiving R-CHOP-21. The prophylactic use of granulocyte colony–stimulating factors (G-CSFs) can significantly reduce the risk of FN. International guidelines recommend G-CSFs for patients receiving chemotherapy with FN risk of 20% or 10 to 20% with defined risk factors. However, there are few studies on the incidence and risk factors of FN in patients with DLBCL receiving R-CHOP-21, especially in patients without primary G-CSF prophylaxis.

Methods
We conducted a retrospective analysis for the clinical data of 103 patients with DLBCL who underwent first R-CHOP-21 without primary G-CSF prophylaxis. The objective of the assessment was the incidence and risk factors of FN after the first chemotherapy cycle.

Results
After the first chemotherapy cycle, the incidence of FN was 20.4%. Multivariate analysis showed that age ≥ 65 years, bone marrow involvement, albumin < 35 g/L, and average relative dose intensity ≥ 80% were independent risk factors for FN. According to risk factors, we created a risk score system. The incidence of FN in the low-, intermediate- and high-risk groups was 5.6%, 17.2%, and 61.9%, respectively.

Conclusion
Our data indicated that R-CHOP-21 itself is associated with a high-risk regiment for FN. We recommend that intermediate/high-risk patients should actively consider primary G-CSF prophylaxis to reduce the incidence of FN after chemotherapy.
Effect of the pipeline embolization device placement on branching vessels in anterior circulation: a systematic review and meta-analysis
Authors: He Yiming , Sun Tao , Han Mengtao , Wang Donghai 
Published: January 2024

Abstract

Background and purpose
Pipeline embolization device (PED) is widely used in intracranial aneurysms, and the scope of applications for the PED, which is frequently used to treat cerebral aneurysms, is also growing. It has some effect on branching vessels as a result of its inherent properties. The effects of PED on the complications rate and branching vessels blockage have not yet been thoroughly investigated.

Objective
We conducted a systematic review searching reports from multiple databases on PED use for intracranial aneurysms, and analyzed the influence of PED on the occlusion rate of different branching vessels, and the influence of the amount of PED on the occlusion rate of branching vessels by meta-analysis.

Methods
We searched the literature using PUBMED, Web of Science, and OVID databases until August 2023. Inclusion criteria were that the study used only PED, included at least 10 patients, and recorded branching vessels occlusion rates, mortality, and neurological complications.

Results
Nine studies were analyzed consisting of 706 patients with 986 side branches. The results of the meta-analysis showed that application of more than one PED did not significantly elevate the rate of branching vessels occlusion compared to application of one PED (OR = 0.70; 95% CI: 0.34 to 1.43; P = 0.33). In the comparison of branching vessels occlusion rates in the anterior circulation, the anterior cerebral artery (ACA) had a significantly higher occlusion rate compared to the ophthalmic artery (OphA) (OR = 6.54; 95% CI: 3.05 to 14.01; P < 0.01), ACA also had a higher occlusion rate compared to the anterior choroidal artery (AchA) (OR = 15.44; 95% CI: 4.11 to 57.94 P < 0.01), ACA versus posterior communicating artery (PcomA) occlusion rate difference was not statistically significant (OR = 2.58; 95% CI: 0.63 to 12.82; P = 0.17), OphA versus AchA occlusion rate difference was not statistically significant (OR = 2.56; 95% CI: 0.89 to 7.38; P = 0.08), and the occlusion rate was significantly higher for PcomA compared to AchA (OR = 7.22; 95% CI: 2.49 to 20.95; P < 0.01) and lower for OphA compared to PcomA (OR = 0.33; 95% CI: 0.19 to 0.55; P < 0.01).

Conclusion
The meta-analysis shows that use of multiple PEDs did not significantly increase the occlusion rate of branching vessels, and the larger the diameter of branching vessels covered by PED, the higher the occlusion rate of branching vessels. However, the incidence of complications is low after branching vessels occlusion in anterior circulation, which is related to the collateral circulation compensation of the branching vessels.