bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laying the groundwork for corporate social responsibility: Behavioral ethics in high‐hazard organizations
Authors: Milosevic Ivana , Bass A. Erin 
Published: January 2024

SummaryUsing findings from an inductive study of two high‐hazard organizations and insights from behavioral ethics literature, we build a model illustrating the behavioral foundations of Corporate Social Responsibility (CSR). We show that employees in high‐hazard organizations scrutinize their work, actively deciding how to alter work tasks and boundaries and persevering through obstacles to lay the groundwork for CSR. Central to this process is employee moral awareness—the awareness of one's activities and the consequences those activities may have on others—through which they translate organizational hazards into their work decisions. Our findings further suggest that moral awareness is more dynamic than previously conceptualized, continually assembled, and reassembled through the active exchange and deployment of scientific and moral principles. In contrast to the extant literature that prioritizes the unitary nature of CSR and its top‐down effects, our findings uncover individual‐level ethical decisions as its foundation and identify moral awareness and work scrutinization as mechanisms through which individuals lay the groundwork for CSR.
Customers' value changes on robot‐serviced restaurants
Authors: Kim Choo Yeon , Cha Seong‐Soo 
Published: January 2024

AbstractThis study investigates the effect of robot‐serviced restaurant's emotional and functional attributes on the consumer value of robot‐serviced restaurant customers. Further, it analyses how the effects changed after the COVID‐19 pandemic began. The survey was conducted on customers who had used Google Drive and visited or indirectly experienced a robot service restaurant in Seoul, Korea through media outlets. The results illustrate that hedonic value influences the emotional attributes more than the functional attributes of robot‐serviced restaurants. In addition, utilitarian value influences functional attributes more than the emotional attributes of these restaurants. However, it is noticeable that the pandemic outbreak has altered these relationships. The study has revealed the influence of consumption values for robot services on the importance of attributes at restaurants and the effects after the pandemic, providing theoretical and practical implications.
Impact of long‐term nasal airflow deprivation on sinonasal structures and chronic rhinosinusitis in total laryngectomy patients
Authors: Park Marn Joon , Bae Mirye , Kim Ji Heui , Chung Yoo‐Sam , Jang Yong Ju , Yu Myeong Sang 
Published: January 2024

AbstractObjectiveTotal laryngectomy (TL) patients are good models in which to evaluate the effects of nasal airflow cessation on the sinonasal tract. Here, we evaluated changes in sinonasal structures and association with sinus opacification in the computed tomography (CT) images 3 years post‐TL.MethodsPatients who underwent TL from 2005 to 2017 in a teaching academic center were reviewed retrospectively. Patients with a final follow‐up CT taken less than 3 years after TL, tracheoesophageal puncture, inadequate CT image, or history of sinonasal surgery were excluded. The control group included patients who underwent a partial laryngectomy or hypopharyngectomy without requiring a tracheotomy for more than a month. Altogether, 45 TL patients and 38 controls were selected. The volume of all four paranasal sinuses, inferior turbinate soft tissue volume (ITSTV), maxillary sinus natural ostium (MSNO) mucosal width, and Lund–Mackay scores (LMS) were measured on preoperative and postoperative CT scans.ResultsThe mean duration between surgery and the final CT scan was 6.3 ± 2.4 and 5.5 ± 2.3 years for the TL and control groups, respectively. Neither group showed significant changes in the four paranasal sinuses' volume or MSNO mucosa width. The ITSTV decreased significantly, from 4.6 ± 1.3 to 2.8 ± 1.1 mL (p < .001), in the TL group, regardless of the presence of nasal septal deviation, showing ITSTV reduction on both concave and convex sides. By contrast, the control group showed no significant changes in ITSTV. Postoperative LMS changes in both groups were insignificant. The number of patients with LMS aggravation or alleviation was the same in both groups, regardless of preoperative sinus opacification.ConclusionsParanasal sinus structures and sinus opacification are not affected significantly by nasal airflow cessation; however, the inferior turbinate mucosa is affected by long‐term discontinuation of nasal airflow.Level of Evidence4 (case–control study).
Reasons for failure of noninvasive prenatal test for cell‐free fetal DNA in maternal peripheral blood
Authors: Kong Xiangsha , Zhang Lin , Yang Ruifeng , Zhang Haiying , Ren Meihong , Wang Xiang , Zhu Ling , Chen Hongsong , Rao Huiying 
Published: January 2024

AbstractBackgroundTo explore reasons for the failure of noninvasive prenatal test (NIPT) for cell‐free fetal DNA (cffDNA) in maternal peripheral blood, and discuss appropriate treatment schemes after the failure of the test.MethodsAltogether 41,136 pregnant women participated in NIPT. Blood samples were taken again from pregnant women who failed the first blood collection upon their informed consent. Prenatal genetic counseling or prenatal diagnosis was recommended for pregnant women with final NIPT failure.ResultsThe first failure rate of NIPT was 0.737% (303/41136), and the reason for the failure was the low ratio of cffDNA in 135 (44.6%) of the 303 pregnant women. After the second or third blood sampling, the final failure rate was 0.182% (75/41136). The low ratio of cffDNA was the main reason for test failure in 42 (56.0%) of the 75 pregnant women who finally failed NIPT, among whom 44 (58.7%) had underlying diseases, including 21 (47.7%) with more than two coexisting underlying diseases. Only 27 (36.0%) of the 75 pregnant women with NIPT failure underwent interventional prenatal diagnosis.ConclusionsThe main reason for NIPT failure was the low ratio of cffDNA. Postponing the gestational weeks of blood collection may improve the success rate. Resampling and retesting upon informed consent in pregnant women who failed the first test could improve the success rate. For pregnant women who finally failed NIPT, it is suggested strengthening the genetic counseling, prenatal examination, and ultrasound evaluation, and carry out interventional prenatal diagnosis if necessary.
Ultra‐wideband imaging with an improved backward projection algorithm for far‐field applications
Authors: Xu Huaqiang , Fan Yucheng , Li Xiaoshuang , Liu Jianwei , Wang Yumeng , Yu Xinchang , Zhao Yuefeng , Wang Jingjing 
Published: January 2024

AbstractUltra‐wideband (UWB) radar imaging is widely used in penetration detection, target location and detection, and vital monitoring because of its high interference immunity and excellent target recognition with high resolution. In this paper, we report the design of a UWB stepper radar imaging system by using a vector network analyzer and a specially designed novel Vivaldi antenna for far‐field imaging applications. An anti‐attenuation backward projection (AA‐BP) algorithm is proposed to alleviate the attenuation impact of electromagnetic wave propagation. The AA‐BP algorithm and the specially designed Vivaldi antenna are jointly applied in our experiments on multiple targets through wall imaging in both free space and multiple‐path propagation environments. The experimental results show that our reported imaging system achieves desirable performances of far‐field imaging.
Preimplantation genetic testing: A remarkable history of pioneering, technical challenges, innovations, and ethical considerations
Authors: Latham Keith E. 
Published: January 2024

AbstractPreimplantation genetic testing (PGT) has emerged as a powerful companion to assisted reproduction technologies. The origins and history of PGT are reviewed here, along with descriptions of advances in molecular assays and sampling methods, their capabilities, and their applications in preventing genetic diseases and enhancing pregnancy outcomes. Additionally, the potential for increasing accuracy and genome coverage is considered, as well as some of the emerging ethical and legislative considerations related to the expanding capabilities of PGT.
A phase 1 study of mebendazole with bevacizumab and irinotecan in high‐grade gliomas
Authors: Krystal Julie , Hanson Derek , Donnelly Danielle , Atlas Mark 
Published: January 2024

AbstractBackgroundHigh‐grade gliomas (HGG) have a dismal prognosis despite multimodal therapy. Mebendazole is an anti‐helminthic benzimidazole that has demonstrated efficacy in numerous in vitro cancer models, and is able to cross the blood–brain barrier. We conducted a phase 1 trial (NCT01837862) to evaluate the safety of mebendazole in combination with bevacizumab and irinotecan in children and young adults with HGG.ObjectiveTo determine the maximally tolerated dose of mebendazole when given in combination with bevacizumab and irinotecan in children with HGG; to describe the progression‐free survival (PFS) and overall survival (OS) for this group.Design/methodPatients between 1 and 21 years of age with HGG were enrolled in a 3 + 3 design to escalating doses of mebendazole in combination with bevacizumab (10 mg/kg/dose) and irinotecan (150 mg/m2/dose). Subjects were eligible upfront after completion of radiation or at the time of progression. Mebendazole was taken orally twice per day continuously, and bevacizumab and irinotecan were given intravenously on Days 1 and 15 of 28‐day cycles.ResultsBetween 2015 and 2020, 10 subjects were enrolled at mebendazole doses of 50 mg/kg/day (n = 3), 100 mg/kg/day (n = 4), and 200 mg/kg/day (n = 3). One subject assigned to 100 mg/kg/day was not evaluable. Seven subjects had a diagnosis of diffuse midline glioma, one subject had anaplastic astrocytoma, and one subject had a spinal HGG. All subjects received radiation. There were no dose‐limiting toxicities. The most frequent G3/4 adverse events were neutropenia (n = 3) and lymphopenia (n = 4). The overall response rate was 33%, with two subjects achieving a partial response and one subject achieving a complete response sustained for 10 months. The mean PFS and OS from the start of study treatment were 4.7 and 11.4 months, respectively.ConclusionMebendazole was safe and well tolerated when administered with bevacizumab and irinotecan at doses up to 200 mg/kg/day. Further studies are needed to determine the efficacy of this treatment.
The behavioral mechanism of Chinese college teachers' teaching engagement: A qualitative study based on the grounded theory
Authors: Zou Yi , Xue Xinyu , Jin Lizhen , Ding Fujun 
Published: January 2024

AbstractConsidering the vital role of college teachers' teaching engagement in guaranteeing the quality of higher education, this study aimed to reveal the behavioral mechanism of Chinese college teachers' teaching engagement through qualitative study based on the grounded theory. It is found that the behavior of Chinese college teachers' teaching engagement is the result of the corresponding intention, which is affected by the three factors of the teaching engagement values, the perceived expectations from the significant others, and the professional knowledge and ability to teach through different ways of interaction. According to the findings, the teaching engagement of college teachers needs to be promoted from three paths: improve teachers' satisfaction of values demands in teaching engagement, reform policy regimes to create a cultural atmosphere that emphasizes teaching engagement, and enhance teachers' professional knowledge and ability of teaching.
Effect of Surface Modification on the Luminescence of Individual Upconversion Nanoparticles
Authors: Ling Huan , Guan Daoming , Wen Rongrong , Hu Jialing , Zhang Yanxin , Zhao Fei , Zhang Yunxiang , Liu Qian 
Published: January 2024

AbstractLanthanide‐doped upconversion nanoparticles (UCNPs) hold promise for single‐molecule imaging owing to their excellent photostability and minimal autofluorescence. However, their limited water dispersibility, often from the hydrophobic oleic acid ligand during synthesis, is a challenge. To address this, various surface modification strategies' impact on single‐particle upconversion luminescence are studied. UCNPs are made hydrophilic through methods like ligand exchange with dye IR806, HCl or NOBF4 treatment, silica coating (SiO2 or mesoporous mSiO2), and self‐assembly with polymer of DSPE‐PEG or F127. The studies revealed that UCNPs modified with NOBF4 and DSPE‐PEG exhibited notably higher single‐particle brightness with minimal quenching (3% and 8%, respectively), followed by SiO2, F127, IR806, mSiO2, and HCl (84% quenching). HCl disrupted UCNPs's crystal lattice, weakening luminescence, while mSiO2 absorbed solvent molecules, causing luminescence quenching. Energy transfer to IR806 also reduced the brightness. Additionally, a prevalence of upconversion red emission over green is observed, with the red‐to‐green ratio increasing with irradiance. UCNPs coated with DSPE‐PEG exhibited the brightest single‐particle luminescence in water, retaining 48% of its original emission due to a lower critical micelle concentration and superior water protection. In summary, the investigation provides valuable insights into the role of surface chemistry on UCNPs at the single‐particle level.
Deep Cracking of Bulky Hydrocarbons into Light Products via Tandem Catalysis over Uniform Interconnected ZSM‐5@AlSBA‐15 Composites
Authors: Zhang Yali , Wang Jiaren , Xie Xianglin , Wang Xiaoning , Wu Winston Duo , Chen Xiao Dong , Wu Zhangxiong 
Published: January 2024

AbstractDeep cracking of bulky hydrocarbons on zeolite‐containing catalysts into light products with high activity, desired selectivity, and long‐term stability is demanded but challenging. Herein, the efficient deep cracking of 1,3,5‐triisopropylbenzene (TIPB) on intimate ZSM‐5@AlSBA‐15 composites via tandem catalysis is demonstrated. The rapid aerosol‐confined assembly enables the synthesis of the composites composed of a continuous AlSBA‐15 matrix decorated with isolated ZSM‐5 nanoparticles. The two components at various ZSM‐5/AlSBA‐15 mass ratios are uniformly mixed with chemically bonded pore walls, interconnected pores, and eliminated external surfaces of nanosized ZSM‐5. The typical composite with a ZSM‐5/AlSBA‐15 mass ratio of 0.25 shows superior performance in TIPB cracking with outstanding activity (≈100% conversion) and deep cracking selectivity (mass of propylene + benzene > 60%) maintained for a long time (> 6 h) under a high TIPB flux (2 mL h−1), far better (several to tens of times higher) than the single‐component and physically mixed catalysts and superior to literature results. The high performance is attributed to the cooperative tandem catalytic process, that is, selective and timely pre‐cracking of TIPB to isopropylbenzene (IPB) in AlSBA‐15 and subsequently timely diffusion and deep cracking of IPB in nanosized ZSM‐5.
Global Existence and Weak-Strong Uniqueness for Chemotaxis Compressible Navier–Stokes Equations Modeling Vascular Network Formation
Authors: Huo Xiaokai , Jüngel Ansgar 
Published: January 2024

AbstractA model of vascular network formation is analyzed in a bounded domain, consisting of the compressible Navier–Stokes equations for the density of the endothelial cells and their velocity, coupled to a reaction-diffusion equation for the concentration of the chemoattractant, which triggers the migration of the endothelial cells and the blood vessel formation. The coupling of the equations is realized by the chemotaxis force in the momentum balance equation. The global existence of finite energy weak solutions is shown for adiabatic pressure coefficients $$\gamma >8/5$$

γ
>
8
/
5

. The solutions satisfy a relative energy inequality, which allows for the proof of the weak–strong uniqueness property.
Value creation in the wine industry—a bibliometric analysis
Authors: Sánchez-García Eduardo , Martínez-Falcó Javier , Marco-Lajara Bartolomé , Georgantzis Nikolaos 
Published: January 2024

AbstractThe main aim of this study is to analyze the literature pertaining to value creation in the wine industry developed in the last two decades, identifying the main contributors such as leading institutions, authors, and countries, and uncovering the main subfields developed by researchers in this area. Bibliometric methods have been used to carry out this research, particularly the R package Bibliometrix®. The results unveil, besides the most relevant contributors, the main subtopics developed in the field of study. It is concluded that value creation is a key factor of success in the wine industry, playing academic research a leading role in revealing consumer trends, health benefits of wine, grape biodiversity, technological developments applicable to production processes, quality improvements of grapes and wines, sustainable practices, brand positioning and other sources of competitive advantage. This research can be of great significance to researchers, policymakers, and managers in the wine industry.
Immune profiling of patients with extranodal natural killer/T cell lymphoma treated with daratumumab
Authors: Qing Min , Zhou Tianyuan , Perova Tatiana , Abraham Yann , Sweeney Cheryl , Krevvata Maria , Zhang Xiaokang , Qi Ming , Gao Grace , Kim Tae Min , Yao Ming , Cho Seok-Goo , Eom Hyeon Seok , Lim Soon Thye , Yeh Su-peng , Kwong Yok Lam , Yoon Dok Hyun , Kim Jin Seok , Kim Won Seog , Zhou Longen , Attar Ricardo , Verona Raluca I. 
Published: January 2024

AbstractNatural killer/T cell lymphoma (NKTCL) is a highly aggressive, heterogeneous non-Hodgkin lymphoma resulting from malignant proliferation of cytotoxic natural killer (NK) or T cells. Previous studies demonstrated variable expression of CD38 on NKTCL tumors. Daratumumab, a human IgGκ monoclonal antibody targeting CD38 with a direct on-tumor and immunomodulatory mechanism of action, was hypothesized to be a novel therapeutic option for patients with relapsed or refractory (R/R) NKTCL. In the phase 2 NKT2001 study (ClinicalTrials.gov Identifier: NCT02927925) assessing the safety and efficacy of daratumumab, a suboptimal overall response rate was seen in R/R NKTCL patients. One patient, whose tumors did not express CD38, responded to treatment, suggesting that the immunomodulatory activities of daratumumab may be sufficient to confer clinical benefit. To understand the suboptimal response rate and short duration of response, we investigated the immune profile of NKTCL patients from NKT2001 in the context of daratumumab anti-tumor activity. Tumor tissue and whole blood were, respectively, analyzed for CD38 expression and patient immune landscapes, which were assessed via cytometry by time-of-flight (CyTOF), multiparameter flow cytometry (MPFC), clonal sequencing, and plasma Epstein-Barr virus (EBV)-DNA level measurements. Changes observed in the immune profiles of NKTCL patients from NKT2001, including differences in B and T cell populations between responders and nonresponders, suggest that modulation of the immune environment is crucial for daratumumab anti-tumor activities in NKTCL. In conclusion, these findings highlight that the clinical benefit of daratumumab in NKTCL may be enriched by B/T cell–related biomarkers.
Prediction of severe infections in chronic lymphocytic leukemia: a simple risk score to stratify patients at diagnosis
Authors: Murru Roberta , Galitzia Andrea , Barabino Luca , Presicci Roberta , La Nasa Giorgio , Caocci Giovanni 
Published: January 2024

AbstractChronic Lymphocytic Leukemia (CLL) is well-known for increasing susceptibility to infections. Factors such as immune dysregulation, IGHV status, hypogammaglobulinemia, and patient comorbidity and treatment, contribute to higher infection rates and mortality. However, the impact of hypogammaglobulinemia on infection rates is controversial. We aimed to identify clinical and biological parameters linked to the risk of severe infectious events. Additionally, we set up a straightforward risk infection score to stratify CLL patients at diagnosis, thereby enabling the development of suitable infection prevention strategies. We retrospectively evaluated 210 unselected CLL patients diagnosed between 1988 and 2018. This evaluation encompassed demographics, Binet stage, immunoglobulin (Ig) levels, treatment history, comorbidities, and IGHV mutational status at diagnosis. The frequency and severity of infectious events were recorded. Analysis revealed that age, IGHV mutational status, Binet stage, and hypogammaglobulinemia were statistically associated with the Time to First Infection (TTFI) in univariate and multivariate analyses. Using hazard ratios from the multivariate analysis, we finally devised a risk scoring system that integrated age, IGHV mutational status, immunoglobulin levels, and Binet stage to stratify patients at diagnosis based on their specific infection risk. In our cohort, disease progression and infections were the leading cause of death. These findings pointed out the clinical need for a screening process strategic for defining infectious risk at the time of CLL diagnosis, with a significant enhancement in the clinical management of these patients.
A verification phase adds little value to the determination of maximum oxygen uptake in well-trained adults
Authors: Bruggisser Fabienne , Wagner Jonathan , Niemeyer Max , Schoch Raphael , Schwendinger Fabian , Schmidt-Trucksäss Arno , Knaier Raphael 
Published: January 2024

Abstract
Purpose
The objective was to investigate if performing a sub-peak or supra-peak verification phase following a ramp test provides additional value for determining 'true' maximum oxygen uptake ($$ {{\dot{\text{V}}}} $$

V
˙

O2).

Methods
17 and 14 well-trained males and females, respectively, performed two ramp tests each followed by a verification phase. While the ramp tests were identical, the verification phase differed in power output, wherein the power output was either 95% or 105% of the peak power output from the ramp test. The recovery phase before the verification phase lasted until capillary blood lactate concentration was ≤ 4 mmol·L−1. If a $$ {{\dot{\text{V}}}} $$

V
˙

O2 plateau occurred during ramp test, the following verification phase was considered to provide no added value. If no $$ {{\dot{\text{V}}}} $$

V
˙

O2 plateau occurred and the highest $$ {{\dot{\text{V}}}} $$

V
˙

O2 ($$ {{\dot{\text{V}}}} $$

V
˙

O2peak) during verification phase was < 97%, between 97 and 103%, or > 103% of $$ {{\dot{\text{V}}}} $$

V
˙

O2peak achieved during the ramp test, no value, potential value, and certain value were attributed to the verification phase, respectively.

Results
Mean (standard deviation) $$ {{\dot{\text{V}}}} $$

V
˙

O2peak during both ramp tests was 64.5 (6.0) mL·kg−1·min−1 for males and 54.8 (6.2) mL·kg−1·min−1 for females. For the 95% verification phase, 20 tests showed either a $$ {{\dot{\text{V}}}} $$

V
˙

O2 plateau during ramp test or a verification $$ {{\dot{\text{V}}}} $$

V
˙

O2peak < 97%, indicating no value, 11 showed potential value, and 0 certain value. For the 105% verification phase, the values were 26, 5, and 0 tests, respectively.

Conclusion
In well-trained adults, a sub-peak verification phase might add little value in determining 'true' maximum $$ {{\dot{\text{V}}}} $$

V
˙

O2, while a supra-peak verification phase adds no value.