bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion basis spectrum imaging detects subclinical traumatic optic neuropathy in a closed-head impact mouse model of traumatic brain injury
Authors: Yang Hsin-Chieh , Lavadi Raj Swaroop , Sauerbeck Andrew D. , Wallendorf Michael , Kummer Terrance T. , Song Sheng-Kwei , Lin Tsen-Hsuan 
Published: December 2023

IntroductionTraumatic optic neuropathy (TON) is the optic nerve injury secondary to brain trauma leading to visual impairment and vision loss. Current clinical visual function assessments often fail to detect TON due to slow disease progression and clinically silent lesions resulting in potentially delayed or missed treatment in patients with traumatic brain injury (TBI).MethodsDiffusion basis spectrum imaging (DBSI) is a novel imaging modality that can potentially fill this diagnostic gap. Twenty-two, 16-week-old, male mice were equally divided into a sham or TBI (induced by moderate Closed-Head Impact Model of Engineered Rotational Acceleration device) group. Briefly, mice were anesthetized with isoflurane (5% for 2.5 min followed by 2.5% maintenance during injury induction), had a helmet placed over the head, and were placed in a holder prior to a 2.1-joule impact. Serial visual acuity (VA) assessments, using the Virtual Optometry System, and DBSI scans were performed in both groups of mice. Immunohistochemistry (IHC) and histological analysis of optic nerves was also performed after in vivo MRI.ResultsVA of the TBI mice showed unilateral or bilateral impairment. DBSI of the optic nerves exhibited bilateral involvement. IHC results of the optic nerves revealed axonal loss, myelin injury, axonal injury, and increased cellularity in the optic nerves of the TBI mice. Increased DBSI axon volume, decreased DBSI λ||, and elevated DBSI restricted fraction correlated with decreased SMI-312, decreased SMI-31, and increased DAPI density, respectively, suggesting that DBSI can detect coexisting pathologies in the optic nerves of TBI mice.ConclusionDBSI provides an imaging modality capable of detecting subclinical changes of indirect TON in TBI mice.
TICRR serves as a prognostic biomarker in lung adenocarcinoma with implications in RNA epigenetic modification, DDR pathway, and RNA metabolism
Authors: Zheng Xunbo , Han Li , Guan Jun , Chen Chenteng , Zhang Yue , Zhang Jiali , Zhang Yiran , Liu Siyao , Su Junyan , Liu Mengyuan , Huang Hanxing 
Published: December 2023

PurposeTOPBP1 interacting checkpoint and replication regulator (TICRR), a hub gene of the Cdk2-mediated initiation step of DNA replication, has been shown an essential role in tumorigenesis by accelerating the DNA replication of tumor cells.MethodsRT-qPCR was used to detect the mRNA expression of TICRR in LUAD tumors and adjacent normal tissues. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database of LUAD were acquired to analyze the critical role of TICRR expression in survival prognosis and clinicopathology characters in LUAD. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA) were performed using the R package. The correlation of TICRR expression with immune cell infiltration, RNA epigenetic modification, DNA damage repair (DDR) pathway, and cell metabolism of LUAD was further explored to verify significant conclusions.ResultsTICRR was significantly upregulated in most cancer types, including LUAD, lung squamous cell carcinoma (LUSC), and others. Cox regression analysis indicated the overexpression of TICRR was associated with poor survival in several cancers. In LUAD, TICRR expression was positively correlated with tumor stage and was increased in smoking, male, and high tumor mutational burden (TMB) patients. Enrichment analysis revealed that TICRR could influence tumor proliferation and prognosis via activating pathways involving cell cycle, DNA repair, DNA replication, cysteine metabolism, oxidative phosphorylation, and ubiquitin-mediated proteolysis pathways. Interestingly, high TICRR expression correlated with DDR pathway signature (34 genes), 37 m6A/m5C regulated genes, and some metabolism-regulated genes. Silencing the TICRR gene affects cysteine metabolism and modifies cancer-related pathways, with decreased cell cycle and increased B/T cell receptor signaling. Our TICRR risk model accurately predicts LUAD patient prognosis, validated across GEO datasets, and is integrated with clinical characteristics via a nomogram, facilitating personalized treatment strategies and enhancing patient management.ConclusionsTaken together, TICRR has emerged as a promising prognostic biomarker in lung adenocarcinoma (LUAD), with implications in immune activation, cell cycle regulation, RNA modification, and tumor energy metabolism. These findings suggest that TICRR could serve as a viable therapeutic target and a reliable prognostic indicator for LUAD.
Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications
Authors: Da Silva Livia E. , Araujo Anna Paula de L. , Almeida James Henrique , de Vasconcelos Ledja. B. O. D. , Silva Messias de O. , Lima Dimas. J. P. , Viana Rodrigo da S. , Ferro Jamylle N. de S. , Goulart Marília O. F. , Xavier Jadriane A. , Barbosa Cintya. D. A. E. S. 
Published: December 2023

The wound healing process is accompanied by changes in pH values. Monitoring this physicochemical parameter can indicate the effectiveness of the applied treatment and act as early identification of wound infection. This study focuses on the development of a fluorescent film-based polyvinyl alcohol (PVA) and carbon dots (CDs) derived from lemon bagasse (CD-L) and ortho-phenylenediamine (CD-oPD) named to act as antioxidants and potential ratiometric fluorescent pH sensors, in wound applications. The I460/I550 intensity ratio, as a function of pH value for the dual-system CDs prepared from the mixture of CD-L and CD-oPD, named CD-L/oPD, was investigated. The fit corresponded to a sigmoidal function in the pH range of 5–10, with a relationship having a r2 = 0.992. The variation in the values of the I460/I550 ratio allows for the visualization of the color change from yellowish-green to green with increasing pH. Through a simulated ex vivo pig skin model, it was possible to note that the films prepared from mixed of the CD-L and CD-oPD carbon dots incorporated in a matrix PVA named CD-L/oPD-F was more efficient at visually discriminating color in relation to changes in pH than the films prepared from both individual CD-L (CD-L-F) and CD-oPD (CD-oPD-F) carbon dots. CD-L and CD-oPD demonstrated antioxidant capacity against reactive oxygen species (ROS). The IC50 values for CD-L and CD-oPD were 56.7 and 39.5 μg mL−1 in the DPPH● inhibition assay, and 25.1 and 63.4 μg mL−1 in the HOCl scavenging one, respectively. MTT viability assays using human non-tumoral skin fibroblast (HFF-1) cell showed a cell survival rate of over 80% for both CDs up to a concentration of 1,000 μg mL−1. Finally, the developed films can act in a bifunctional way, by monitoring healing through pH changes and by acting as an antioxidant agent in the treatment of wounds.
Lavandula pedunculata Polyphenol-Rich Extracts Obtained by Conventional, MAE and UAE Methods: Exploring the Bioactive Potential and Safety for Use a Medicine Plant as Food and Nutraceutical Ingredient
Authors: Vilas-Boas Ana A. , Goméz-García Ricardo , Machado Manuela , Nunes Catarina , Ribeiro Sónia , Nunes João , Oliveira Ana L. S. , Pintado Manuela 
Published: December 2023

Nowadays, plant-based bioactive compounds (BCs) are a key focus of research, supporting sustainable food production and favored by consumers for their perceived safety and health advantages over synthetic options. Lavandula pedunculata (LP) is a Portuguese, native species relevant to the bioeconomy that can be useful as a source of natural BCs, mainly phenolic compounds. This study compared LP polyphenol-rich extracts from conventional maceration extraction (CE), microwave and ultrasound-assisted extraction (MAE and UAE). As a result, rosmarinic acid (58.68–48.27 mg/g DE) and salvianolic acid B (43.19–40.09 mg/g DE) were the most representative phenolic compounds in the LP extracts. The three methods exhibited high antioxidant activity, highlighting the ORAC (1306.0 to 1765.5 mg Trolox equivalents (TE)/g DE) results. In addition, the extracts obtained with MAE and CE showed outstanding growth inhibition for B. cereus, S. aureus, E. coli, S. enterica and P. aeruginosa (>50%, at 10 mg/mL). The MAE extract showed the lowest IC50 (0.98 mg DE/mL) for angiotensin-converting enzyme inhibition and the best results for α-glucosidase and tyrosinase inhibition (at 5 mg/mL, the inhibition was 87 and 73%, respectively). The LP polyphenol-rich extracts were also safe on caco-2 intestinal cells, and no mutagenicity was detected. The UAE had lower efficiency in obtaining LP polyphenol-rich extracts. MAE equaled CE’s efficiency, saving time and energy. LP shows potential as a sustainable raw material, allowing diverse extraction methods to safely develop health-promoting food and nutraceutical ingredients.
Exploring whether primary care networks can contribute to the national goal of reducing health inequalities: a mixed-methods study
Authors: Warwick-Giles Lynsey , Hutchinson Joseph , Checkland Kath , Hammond Jonathan , Bramwell Donna , Bailey Simon , Sutton Matt 
Published: December 2023

BackgroundSignificant health inequalities exist in England. Primary care networks (PCNs), comprised of GP practices, were introduced in England in 2019 with funding linked to membership. PCNs have been tasked with tackling health inequalities.AimTo consider how the design and introduction of PCNs might influence their ability to tackle health inequalities.Design and settingA sequential mixed-methods study of PCNs in England.MethodLinear regression of annual PCN-allocated funding per workload-weighted patient on income deprivation score from 2019–2023 was used. Qualitative interviews and observations of PCNs and PCN staff were undertaken across seven PCN sites in England (July 2020–March 2022).ResultsAcross 1243 networks in 2019–2020, a 10% higher level of income deprivation resulted in £0.31 (95% confidence interval [CI] = £0.25 to £0.37), 4.50%, less funding per weighted patient. In 2022–2023, the same difference in deprivation resulted in £0.16 (95% CI = £0.11 to £0.21), 0.60%, more funding. Qualitative interviews highlighted that, although there were requirements for PCNs to tackle health inequalities, the policy design, and PCN internal relationships and maturity, shaped and sometimes restricted how PCNs approached this task locally.ConclusionAllocated PCN funding has become more pro-poor over time, suggesting that the need to account for deprivation within funding models is understood by policymakers. The following additional approaches have been highlighted that could support PCNs to tackle inequalities: better management support; encouragement and support to redistribute funding internally to support practices serving more deprived populations; and greater specificity in service requirements.
Comparison of Tourism and Hospitality Industry Financial Performance Before and After COVID-19
Authors: Nurwitasari Ayu , Waspada Ikaputera , Sari Maya 
Published: December 2023

Purpose of the study: The COVID-19 pandemic has made the tourism sector unstable, where during the COVID-19 pandemic, the tourism industry faced several risks such as decreased revenue and operating profits, this decline certainly affected the company's financial performance. This study aims to explore and describe the trends and evolution of the latest academic literature on the financial performance of the tourism industry before and after the COVID-19 pandemic which were published as relevant articles.
Design/methodology: This study uses the concept of literature review using the Systematic Literature Review (SLR) technique. The Systematic Literature Review technique is an important feature of academic research. By summarizing, analyzing, and synthesizing a group of related literature, can test certain hypotheses and/or develop new theories.
Findings: The results of the study show that the financial performance of the tourism industry before and after COVID-19 is dominant using profitability ratio measurements.
Research limitations/Implications: One limitation of this study is the reliance on secondary data sources for the literature review. As the study uses the Systematic Literature Review (SLR) technique, it may be limited by the availability and quality of existing literature on the financial performance of the tourism industry before and after the COVID-19 pandemic.
Novelty/Originality of the study: This research can be used as material for consideration for conducting further research on the financial performance using activity ratios and market ratios.
Consumer Spending in the Mirror of Aggregate Transfer Accounts: National and Regional Aspects
Authors: Nazarova A. G. 
Published: December 2023

Building upon a series of the author’s prior publications in the journal Voprosy Statistiki (in 2019–2022), this new article further deve- lops the idea of applying National Transfer Accounts (NTAs) as a toolkit for economic and demographic analysis of a wide range of macro patterns in the economy, both nationally and on the regional level. The author highlights the NTAs' practical utility, allowing for a more detailed, compared to the System of National Accounts (SNA), analysis of the reallocation of financial resources, including through the prism of dependents and those who finance them. It includes a concise description of the current research concept and the methodology approach chosen for the analysis.Based on the author's calculations of the analyzed indicators at the national and regional levels, the body of the article confirms that the influence of the age structure of society on consumer spending of the population manifests itself in the priorities of consumer demand. On the macro level, the comparative example of Russia, Sweden and Mexico shows commonalities and specificities in the financing of con- sumer demand by resources of the private and public sectors and the corresponding timespans of running deficit-free economic lifecycle in these countries. As a comparative framework for the Russian economy, the countries with the most (Sweden) and least (Mexico) generous state subsidies for the consumption of the population in the form of current transfer support were selected. In the regional aspect of the analysis, the structural characteristics of the age profile of the regions (from 2011 to 2020) were compared with the accumulated (per capita) dynamics of regional consumer spending with a pronounced age bias (on education and healthcare). The regional results were analyzed in the context of the overall economic situation. The article illustrates the qualitatively different consumer demand priorities of the «young» and «advanced- in-years» regions by the comparative infographics case studying the Republic of Ingushetia and Tver Region (regions with diametrically opposite features of the demographic structure). The author has dealt with consumer behavior models across various ages in the context of the Strauss-Howe generational theory, devised by William Strauss and Neil Howe.The author demonstrates how the COVID-19 pandemic impacted the sources of financing household spending on the level of the economy as a whole.The concluding section draws methodological parallels between national transfer accounts and such summary indicators as human de- velopment indices and the UN Sustainable Development Goals to be considered in macroeconomic and regional analysis
Persepsi Masyarakat Kota Manado Terhadap Vaksin Booster Covid-19 sebagai Syarat Berwisata
Authors: Mandak Kevin A. G. , Pangemanan Damajanty H. C. , Doda Diana V. D. 
Published: December 2023

Abstract: Coronavirus disease 2019 (Covid 19) is an infectious disease that is currently a global pandemic. This situation greatly impacts the tourism sector in Indonesia. Vaccination is expected to be one of the preventive measures used to control the transmission of Covid-19. This study aimed to determine the perception of the people in Manado City towards the Covid-19 booster vaccine as a prerequisite for traveling. This was a qualitative study using interview method. The interview was conducted using in-depth interview technique and guidelines. The results obtained 15 people of Kelurahan Paniki Bawah, Kecamatan Mapanget, Kota Manado as respondents. Most respondents had positive perception towards the Covid-19 booster vaccine as a prerequisite of traveling. Most respondents had good general understanding of the benefits of the Covid-19 vaccine and they agreed with the Covid-19 booster vaccine as a prerequisite of traveling. In conclusion, most people in Manado City have a good and positive perception of the Covid-19 booster vaccine as a prerequisite of traveling.
Keywords: Covid-19; booster vaccine; travelling prerequisite

Abstrak: Penyakit infeksi coronavirus 2019 (Covid 19) telah menjadi pandemi global. Situasi tersebut sangat berdampak pada sektor pariwisata di Indonesia. Pemberian vaksin diharapkan dapat menjadi salah satu pencegahan yang digunakan untuk mengendalikan penularan Covid-19. Penelitian ini bertujuan untuk mengetahui persepsi masyarakat Kota Manado terhadap vaksin booster Covid-19 sebagai syarat berwisata. Penelitian ini merupakan penelitian kualitatif dengan metode wawancara secara terstruktur dan menggunakan pedoman wawancara. Hasil penelitian mendapatkan 15 masyarakat Kelurahan Paniki Bawah, Kecamatan Mapanget, Kota Manado sebagai responden penelitian. Persepsi responden terhadap vaksin booster Covid-19 sebagai syarat berwisata menunjukkan bahwa sebagian besar memiliki persepsi positif terhadap vaksin booster Covid-19 sebagai syarat berwisata. Responden memiliki pemahaman umum yang baik mengenai manfaat vaksin covid dan mereka setuju dengan himbauan vaksin bo booster oster Covid-19 sebagai syarat berwisata. Simpulan penelitian ini ialah masyarakat Kota Manado umumnya memiliki persepsi yang baik terhadap vaksin booster Covid-19 sebagai syarat berwisata.
Kata kunci: Covid-19; vaksin booster; syarat berwisata
Material database for the mechanical design of components made of powder metallurgy material
Authors: Miao Jiacheng , Zhang Luhe , Li Zeying , Chen Bingkui 
Published: December 2023

The powder metallurgy database is a data system for effective management
of powder metallurgy information. With the development of information
technology, its construction scale and quality will directly affect the
convenient inquiry of powder metallurgy information, the selection of
gear materials, the research and development and engineering application
of micro-drive systems, and have engineering significance and market
value. However, the groundwork in this field still lags behind other
materials fields and needs to be developed systematically.
Consider the small modulus powder metallurgy gear’s elastic modulus,
Poisson’s ratio, fatigue life, metallographic structure and processing
parameters as research objectives, the functional requirements of the
database, system functions and data relationships are analyzed. The
function module, database model, user authority and system architecture
are designed in detail. Based on the Flask framework and MySQL, the
database system on the basic properties of powder metallurgy materials
is designed and developed, which realizes the systematic and
standardization of mechanical property data of powder metallurgy. Users
are provided with upload, query and retrieval services of chemical
composition, heat treatment and molding properties, fracture mechanics,
material suppliers and other information.
In this paper, the necessity and urgency of building a powder metallurgy
database to increase the efficiency of transmission system development
and its application are demonstrated. The deficiencies of the existing
powder metallurgy database are analyzed, and suggestions are provided
for the selection, design, data coverage, and construction of big data
applications for smart materials. The technical challenges of small
modulus powder metallurgy gear selection and plan formulation are then
ameliorated.
Github repository:
PMdatabase2 (github.com)
FLOODED JET OF SELF-FOAMING GAS-AEROSOL FOAM WHEN EXTINGUISHING PETROLEUM PRODUCT FIRES IN TANKS BY SUB-LAYER METHOD
Authors: Копылов Н.П. , Федоткин Д.В. , Сушкина Е.Ю. , Москвилин Е.А. 
Published: December 2023

Тушение пожаров нефтепродуктов в резервуарах с использованием технологии получения самовспенивающейся газоаэрозоленаполненной пены и подачей ее в слой горючего является наиболее перспективным направлением. В статье проанализированы методы расчета осевой скорости турбулентной затопленной струи в жидкости. Эти методы базируются на решении уравнений Навье-Стокса с привлечением экспериментальных данных. Выполнен расчет осевой скорости струи по разным формулам и для различных уровней взлива нефтепродуктов. Получена хорошая сходимость результатов расчетов и экспериментальных данных.
Under-layer extinguishing of petroleum product fires in tanks is widely used in practice, but has a number of significant drawbacks – dissolution of foam in alcohol-containing fuels, failure to penetrate the water cushion and strongly heated layer of fuel. A new extinguishing technology using the technology of self-foaming gas-aerosol foam (SGF) allows to overcome the noted disadvantages of the classical method of under-layer extinguishing. According to this technology, the foam is supplied in the form of a flooded turbulent jet, flowing from a pipe in the base of the tank. The maximum height of the tank, according to modern standards, is 18 meters. The question arises as to what parameters a turbulent flood jet will penetrate the oil product layer and spread over the surface of the tank mirror. The motion of a flooded turbulent jet in a liquid is described by a system of Navier-Stokes equations. This system can be solved analytically with some assumptions or numerically. When solving this problem, some coefficients appear, which, as a rule, are determined experimentally. In this article, various approaches to solving the Navier-Stokes equations for determining the axial velocity of a turbulent flooded jet are considered in the axisymmetric formulation. Calculation formulas and values of empirical constants are determined. The calculation of velocity values on the axis of turbulent flooded jet has been carried out for values of its initial velocity U0 = 35 m ∙ s–1 and pipe diameter D0 = 0,159 m, through which the stream flows out. The values of these parameters are realized in practice in the installation “Uragan”, which implements the technology of obtaining SGF. The calculation results were compared with the data obtained in natural experiments, their good agreement was obtained. As a result, it has been experimentally and computationally proved that the new technology of sub-layer fire extinguishing of SGF is effective.