bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Mexican Border rift structural inheritance on Laramide rivers of the Tornillo basin, west Texas (USA): Insights from detrital zircon provenance
Authors: Kortyna Cullen , Stockli Daniel F. , Lawton Timothy F. , Covault Jacob A. , Sharman Glenn R. 
Published: October 2023

AbstractLate Cretaceous to Eocene Laramide basement–involved shortening fragmented the Sevier and Mexican foreland basins. This resulted in a major drainage reorganization in response to the emerging topography of Laramide basement–cored uplifts and Mexican inverted Border rift basins. This study presents new depth-profile detrital zircon U-Pb data (3679 ages from 28 samples) from Upper Cretaceous–Eocene fluvial strata of the Tornillo basin in west Texas to determine sedimentary provenance and reconstruct sediment dispersal through the U.S.-Mexico border region. Detrital zircon U-Pb data are dominated by Hauterivian–Coniacian (130–87 Ma; ~20%) and Coniacian–Ypresian (87–52 Ma; ~30%) ages that represent Cordilleran and Laramide arc magmatism, respectively. Subordinate age groups are Paleoproterozoic–Mesoproterozoic (1900–1300 Ma; ~12%), Ectasian–Tonian (1300–900 Ma; ~8%), Tonian–Pennsylvanian (900–300 Ma, ~10%); Permian–Triassic (300–200 Ma; ~8%), and Jurassic–Early Cretaceous (200–130 Ma; ~11%). Detrital zircon maximum depositional ages provide new constraints on the chronostratigraphic framework of the Tornillo Group, the stratigraphic nature of the Cretaceous-Paleogene boundary, and the stratigraphic level of the Paleocene–Eocene thermal maximum. Depth-profile core-rim age pairs yielded Paleoproterozoic–Mesoproterozoic and Jurassic cores with Cretaceous–Paleogene rims, which represent zircons derived from Laramide magmatic rocks that intruded Yavapai-Mazatzal basement and Cordilleran-Nazas magmatic rocks. Zircon grains with Ectasian–Tonian cores and Paleozoic rims likely represent Appalachian-derived and/or Coahuila terrane zircons recycled from the inverted Mesozoic Bisbee basin and Chihuahua trough. These results demonstrate that fluvial strata in the Tornillo basin were sourced from Laramide and Cordilleran magmatic rocks, Yavapai-Mazatzal basement, and recycled Mexican Border rift sedimentary rocks in the southwest United States and northern Sonora, and these sediments were delivered via a large (&gt;103-km-long), axial-trunk river. Additional recycled detritus from Mexican Border rift sedimentary rocks in the Chihuahua fold belt was delivered via transverse tributaries. This drainage reconstruction indicates that the Tornillo river flowed along an inversion-flank drainage corridor adjacent to topography formed by the inverted Mexican Border rift. Therefore, inherited Mexican Border rift architecture represented a first-order control on sediment routing to the Tornillo basin.
The eight architectural zones of nonmarine basins
Authors: Loughney Katharine M. , Holland Steven M. 
Published: October 2023

AbstractOne of the goals of sequence stratigraphy is to model the conditions that generate stratigraphic architecture at outcrop to basin scales. Accommodation and sedimentation are the principal variables included in sequence-stratigraphic models that describe facies architecture in marine successions. Similar models exist to describe wholly nonmarine architecture. Distinct models are commonly applied to basins containing predominantly lacustrine or predominantly fluvial facies, which can make it difficult to apply models to the entire history of a basin that may include both lacustrine-dominated or fluvial-dominated phases, depending on climatic and tectonic conditions. To account for these changing conditions over the history of nonmarine basins, we present a conceptual three-dimensional model that describes the potential architectural patterns under specific combinations of accommodation, sediment flux, and water balance. Sectors of the model delineate where basins are underfilled or overfilled with respect to accommodation and limited with respect to sediment and water, creating eight zones with different implications for the development of facies architecture. Different types of basins (e.g., foreland, extensional, pull-apart, intracratonic) show broadly different trends in architecture through time. Subtle changes in accommodation, sedimentation, and water balance in the model correspond to shifts in facies architecture between lithostratigraphic units, but architectural transitions within individual basins are more important indicators of evolving basin conditions than comparisons among all basins. This model may serve as a guide for comparing the influence of distinct drivers of architecture among different types of basins as well as identifying important intervals of change during the history of basin filling. The availability of commensurate data on the history of accommodation, sedimentation, and water balance is, however, an ongoing challenge to reconstructing complete basin histories. Future analyses will test how well predicted facies stacking patterns compare to observed nonmarine stratigraphic successions resulting from the combination of accommodation, sediment flux, and water balance during the history of basin filling.
Association between the extension of smoke-free legislation and incident acute myocardial infarctions in Singapore from 2010 to 2019: an interrupted time-series analysis
Authors: Ho Jamie S Y , Ho Andrew F W , Jou Eric , Liu Nan , Zheng Huili , Aik Joel 
Published: October 2023

BackgroundWe examined the association between smoke-free laws implemented in the outdoors and the common areas of residential apartment blocks and reported acute myocardial infarctions (AMI) in Singapore.MethodsWe used an interrupted time-series design and seasonal autoregressive integrated moving average models to examine the effect of the smoke-free law extensions in 2013 (common areas of residential blocks, covered pedestrian linkways, overhead bridges and within 5 m of bus stops), 2016 (parks) and 2017 (educational institutions, buses and taxis) on the monthly incidence rate of AMIs per 1 000 000 population.ResultsWe included 133 868 AMI reports from January 2010 to December 2019. Post-2013, there was a decrease in the AMI incidence trend (β=−0.6 per month, 95%CI −1.0 to –0.29) and 2097 (95% CI 2094 to 2100) more AMIs may have occurred without the extension. There was a significant step-decline in male AMIs and a non-significant step-increase in female AMIs post-2013. Those 65 years and older experienced a greater decline to the postlegislation 2013 trend (β=−5.9, 95% CI −8.7 to –3.1) compared with those younger (β=−0.4, 95% CI −0.6 to –0.2), while an estimated 19 591 (15 711 to 23472) additional AMI cases in those 65 years and above may have occurred without the extension. We found a step-increase in monthly AMI incidence post-2016 (β=14.2, 95%CI 3.3 to 25.0).ConclusionThe 2013 smoke-free law extension to residential estates and other outdoor areas were associated with a decline in AMIs and those above the age of 65 years and men appeared to be major beneficiaries. Additional epidemiological evidence is required to support the expanded smoke-free legislation to parks, educational institutions, buses and taxis.
Performance of predictive algorithms in estimating the risk of being a zero-dose child in India, Mali and Nigeria
Authors: Biswas Arpita , Tucker John , Bauhoff Sebastian 
Published: October 2023

IntroductionMany children in low-income and middle-income countries fail to receive any routine vaccinations. There is little evidence on how to effectively and efficiently identify and target such ‘zero-dose’ (ZD) children.MethodsWe examined how well predictive algorithms can characterise a child’s risk of being ZD based on predictor variables that are available in routine administrative data. We applied supervised learning algorithms with three increasingly rich sets of predictors and multiple years of data from India, Mali and Nigeria. We assessed performance based on specificity, sensitivity and the F1 Score and investigated feature importance. We also examined how performance decays when the model is trained on older data. For data from India in 2015, we further compared the inclusion and exclusion errors of the algorithmic approach with a simple geographical targeting approach based on district full-immunisation coverage.ResultsCost-sensitive Ridge classification correctly classifies most ZD children as being at high risk in most country-years (high specificity). Performance did not meaningfully increase when predictors were added beyond an initial sparse set of seven variables. Region and measures of contact with the health system (antenatal care and birth in a facility) had the highest feature importance. Model performance decreased in the time between the data on which the model was trained and the data to which it was applied (test data). The exclusion error of the algorithmic approach was about 9.1% lower than the exclusion error of the geographical approach. Furthermore, the algorithmic approach was able to detect ZD children across 176 more areas as compared with the geographical rule, for the same number of children targeted.InterpretationPredictive algorithms applied to existing data can effectively identify ZD children and could be deployed at low cost to target interventions to reduce ZD prevalence and inequities in vaccination coverage.
Sustaining a culture of safety and optimising patient outcomes while implementing zero harm programme: a 2-year project of the nursing services – SBAHC
Authors: Obaid Lina Mohammed , Ali Ibrahim , Al Baker Ahmad , Al Shiekh Abdallah Wisal Othman , Plando Rhez Legaspi , Khawaldeh Mohammed Elian , Panaligan Ria Kharen Joy 
Published: October 2023

This quality improvement report details how Sultan Bin Abdulaziz Humanitarian City (The City), the largest rehabilitation facility within Middle East with a capacity of 511 beds and more than 20 nursing in-patient units improved the quality and patient safety culture in nursing services after successfully adopting and implementing the zero harm programme.In healthcare settings, the idea of zero harm including zero incidents, zero injuries and injury-free are commonly used to highlight the importance of patient safety. Patient injuries and deaths resulting from hospital-acquired illnesses such as medication administration errors, falls, central line-associated bloodstream infections, hospital-acquired pressure injuries and catheter-associated urinary tract infection are largely preventable and grossly unacceptable occurrences. Achieving zero incidents of such critical measures can significantly impact treatment plan and enhance patient experience.The projects’ purpose was to build a new culture of safety by implementing innovative strategy designed to protect patients from preventable harm while maintaining an extraordinary high standard of quality patient care. Additionally, the programme was established with the aim of instilling a sense of commitment to every nurse working in this organisation to anticipate potential harms and to be vigilant to prevent it before it reaches the patient.This document also describes a set of initiatives aimed at mitigating preventable incidents and ultimately achieving zero harm on our organisation. The result showed a significant increase by 95% between the percentage of nursing units that had 365 days of zero harm in 2020 and 2021. This improvement indicates that the concept of zero harm had been successfully inculcated among nursing units and had motivated nursing staff to uphold a higher culture of patient safety. Furthermore, by incorporating the Just Culture model into the electronic reporting system, the reporting rate of occurrences in the zero-harm programme was supported and sustained.
Evaluation of procedural pain for neonates in a neonatal intensive care unit: a single-centre study
Authors: Luo Feixiang , Zhu Huaiyu , Mei Lingli , Shu Qi , Cheng Xiaoying , Chen Xiaofei , Zhao Yisheng , Chen Shuohui , Pan Yun 
Published: October 2023

BackgroundTo evaluate the procedural pain experienced by neonates in a neonatal intensive care unit (NICU) setting and determine the corresponding pain grades.MethodsTwo experienced nurses independently used the Neonatal Infant Pain Scale (NIPS) to evaluate the neonatal pain during procedures taking place in the tertiary NICU and two level-two neonatal care units in the Children’s Hospital of Zhejiang University School of Medicine. The mean and distribution of NIPS pain scores and the corresponding pain grades of participants when experiencing clinical painful procedures were analysed.ResultsA total of 957 neonates exposed to 15 common clinical painful procedures were included in the study. The clinical painful procedures experienced by 957 participants could be divided into three groups: severe pain (NIPS score 5–7: peripheral intravenous cannulation, arterial catheterisation, arterial blood sampling, peripherally inserted central catheter placement and nasopharyngeal suctioning), mild to moderate pain (NIPS score 3–4: finger prick, intramuscular injection, adhesive removal, endotracheal intubation suctioning, heel prick, lumbar puncture and subcutaneous injection) and no pain to mild pain (NIPS score 0–2: gastric tube insertion, enema and intravenous injection).ConclusionsThe neonatal pain response to clinical procedures in NICU had certain pattern and preintervention drug analgesia could be taken for painful procedures with clustered high NIPS pain scores. Meanwhile, full coverage non-drug pain relief measures could be taken for procedures that are with scattered pain scores, and real-time pain evaluation should be provided to determine whether further drug analgesia is required.
Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease: a phase I/II clinical trial
Authors: Xie Xinyi , Song Qingxiang , Dai Chengxiang , Cui Shishuang , Tang Ran , Li Suke , Chang Jing , Li Ping , Wang Jintao , Li Jianping , Gao Chao , Chen Hongzhuan , Chen Shengdi , Ren Rujing , Gao Xiaoling , Wang Gang 
Published: October 2023

BackgroundThere have been no effective treatments for slowing or reversing Alzheimer’s disease (AD) until now. Growing preclinical evidence, including this study, suggests that mesenchymal stem cells-secreted exosomes (MSCs-Exos) have the potential to cure AD.AimsThe first three-arm, drug-intervention, phase I/II clinical trial was conducted to explore the safety and efficacy of allogenic human adipose MSCs-Exos (ahaMSCs-Exos) in patients with mild to moderate AD.MethodsThe eligible subjects were assigned to one of three dosage groups, intranasally administrated with ahaMSCs-Exos two times per week for 12 weeks, and underwent follow-up visits at weeks 16, 24, 36 and 48.ResultsNo adverse events were reported. In the medium-dose arm, Alzheimer’s Disease Assessment Scale–Cognitive section (ADAS-cog) scores decreased by 2.33 (1.19) and the basic version of Montreal Cognitive Assessment scores increased by 2.38 (0.58) at week 12 compared with baseline levels, indicating improved cognitive function. Moreover, the ADAS-cog scores in the medium-dose arm decreased continuously by 3.98 points until week 36. There were no significant differences in altered amyloid or tau deposition among the three arms, but hippocampal volume shrank less in the medium-dose arm to some extent.ConclusionsIntranasal administration of ahaMSCs-Exos was safe and well tolerated, and a dose of at least 4×108particles could be selected for further clinical trials.Trial registration numberNCT04388982.
Investigating the influence of selected leadership styles on patient safety and quality of care: a systematic review and meta-analysis
Authors: Singh Ankit , Yeravdekar Rajiv , Jadhav Sammita 
Published: October 2023

BackgroundThere is a popular belief that transformational leadership (TL) and servant leadership (SL) styles are influential in establishing a patient safety (PS) culture and improving the quality of care (QC). However, there are very few review articles investigating this phenomenon.PurposeThis study performs a systematic review and meta-analysis to ascertain the influences of TL and SL on PS and QC.MethodsPublished research work indexed in the two popular databases, that is, Scopus and PubMed, was selected based on the inclusion criteria. The systematic review was performed as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data such as country of publication, year, data type, research design, target population, sample size and conclusion were selected from the studies.ResultsThere are pieces of evidence suggesting a medium to strong effect of TL on PS. At the same time, the effect of TL on QC is not direct but indirect and is mediated through variables such as fostering positive organisational culture and enhancing organisational outcomes such as job satisfaction, leader effectiveness and willingness of nurses to spend some extra effort. A total of 27 studies were selected for final evaluation and 11 reported a relationship between TL and PS. The ‘Fisher r-to-z transformed correlation coefficients’ ranged from 0.3769 to 0.8673. Similarly, a total of four studies reported the relationship between TL and QC, ‘Fisher r-to-z transformed correlation coefficients’ ranged from 0.0802 to 0.5101, with most estimates being positive (80%).ConclusionTL has a strong and positive effect on PS but a positive and weak effect on the QC. There is not much evidence to establish SL’s influence on PS and QC.
FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
Authors: Pifer Phillip M. , Yang Liangpeng , Kumar Manish , Xie Tongxin , Frederick Mitchell , Hefner Andrew , Beadle Beth , Molkentine David , Molkentine Jessica , Dhawan Annika , Abdelhakiem Mohamed , Osman Abdullah A. , Leibowitz Brian J. , Myers Jeffrey N. , Pickering Curtis R. , Sandulache Vlad C. , Heymach John , Skinner Heath D. 
Published: October 2023

Abstract

Purpose:
Radiation and platinum-based chemotherapy form the backbone of therapy in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). We have correlated focal adhesion kinase (FAK/PTK2) expression with radioresistance and worse outcomes in these patients. However, the importance of FAK in driving radioresistance and its effects on chemoresistance in these patients remains unclear.

Experimental Design:
We performed an in vivo shRNA screen using targetable libraries to identify novel therapeutic sensitizers for radiation and chemotherapy.

Results:
We identified FAK as an excellent target for both radio- and chemosensitization. Because TP53 is mutated in over 80% of HPV-negative HNSCC, we hypothesized that mutant TP53 may facilitate FAK-mediated therapy resistance. FAK inhibitor increased sensitivity to radiation, increased DNA damage, and repressed homologous recombination and nonhomologous end joining repair in mutant, but not wild-type, TP53 HPV-negative HNSCC cell lines. The mutant TP53 cisplatin-resistant cell line had increased FAK phosphorylation compared with wild-type, and FAK inhibition partially reversed cisplatin resistance. To validate these findings, we utilized an HNSCC cohort to show that FAK copy number and gene expression were associated with worse disease-free survival in mutant TP53, but not wild-type TP53, HPV-negative HNSCC tumors.

Conclusions:
FAK may represent a targetable therapeutic sensitizer linked to a known genomic marker of resistance.
CD38 x ICAM-1 Bispecific Antibody Is a Novel Approach for Treating Multiple Myeloma and Lymphoma
Authors: Chen Xiaocheng , Wong Oi Kwan , Reiman Lauren , Sherbenou Daniel W. , Post Leonard 
Published: October 2023

Abstract
The cluster of differentiation 38 (CD38) is a well-validated target for treating multiple myeloma. Although anti-CD38 mAbs have demonstrated outstanding initial responses in patients with multiple myeloma, nearly all patients eventually develop resistance and relapse. In addition, currently approved CD38 targeting therapies have failed to show monotherapy efficacy in lymphomas, where CD38 expression is present but at lower levels. To effectively target CD38 on tumor cells, we generated an antibody-dependent cellular cytotoxicity (ADCC) enhanced bispecific CD38 x intercellular cell adhesion molecule 1 (ICAM-1) antibody, VP301. This bispecific antibody targets unique epitopes on CD38 and ICAM-1 on tumor cells with reduced red blood cell binding compared with the benchmark CD38 antibody daratumumab. VP301 demonstrated potent ADCC and antibody-dependent cellular phagocytosis activities on a selected set of myeloma and lymphoma cell lines even those with low CD38 expression. In an ex vivo drug sensitivity assay, we observed responses to VP301 in multiple myeloma primary samples from relapsed/refractory patients. Moreover, VP301 demonstrated potent tumor inhibition activities in in vivo myeloma and lymphoma models. Interestingly, combination of VP301 with the immunomodulatory drug, lenalidomide, led to synergistic antitumor growth activity in an in vivo efficacy study. In conclusion, the CD38 x ICAM-1 bispecific antibody VP301 demonstrated promising efficacy and specificity toward CD38+ and ICAM-1+ tumor cells and represents a novel approach for treating multiple myeloma and lymphoma.
Demand Shocks, Procurement Policies, and the Nature of Medical Innovation: Evidence from Wartime Prosthetic Device Patents
Authors: Clemens Jeffrey , Rogers Parker 
Published: October 2023

Abstract
We show that the demand shocks associated with the U.S. Civil War and World War I led to substantial increases in prosthetic device patenting (relative to patenting in other medical and mechanical technology classes). Through analyses of patent texts, we find that the Civil War led inventors to focus on production process improvements, while World War I did not. Further, we find that inventors emphasized dimensions of product quality that aligned with differences in buyers' preferences across wars. Alongside evidence from the historical record, these findings imply that procurement environments can significantly shape the scientific problems with which inventors engage.
What Triggers Mortgage Default? New Evidence from Linked Administrative and Survey Data
Authors: Low David 
Published: October 2023

Abstract
Why do homeowners default on mortgages? This paper studies the question using a survey specifically designed for the purpose, with a sample drawn from (and matched to) very rich administrative data. I find that a wide variety of typically-unobserved liquidity shocks together trigger nearly all defaults, so “strategic” default with no liquidity trigger is much less common than it usually appears. Conversely, even in this uniquely rich data I find that many foreclosures are not triggered by negative home equity, contrary to the predictions of almost every model in the literature.
The Challenge of Christian Deliberation in a Libertarian Context
Authors: Glenna Leland L. , Stofferahn Curtis W. 
Published: October 2023

Abstract
In 2005, the Evangelical Lutheran Church in America’s (ELCA) Churchwide Assembly authorized the formation of a task force to prepare a social statement on genetics and faith. Although the Churchwide Assembly voted to adopt the social statement in August of 2011 by a wide margin, there had been an earlier controversy. In June 2010, an article in the Dakota Farmer questioned whether the ELCA was accusing farmers of “sin” for planting genetically engineered crop seeds. At least two churches in rural North Dakota cited this factor as a reason for leaving the ELCA. Seven synods with strong farmer constituencies proposed resolutions challenging the social statement. This paper explores how the opposition used agrarianism and libertarianism to attack the ELCA’s use of the Christian concept of the common good in the social statement. This case reveals the challenges that the Church faces when contributing to ethical deliberations on controversial issues.