bluuebunny/crossref_metadata_2025_split huggingface dataset:
Putting Guidelines Into Practice: Is Frailty Measurement at the Time of Kidney Transplant Eligibility Assessment Valid, Feasible, and Acceptable to Patients?
Authors: Weerasekera Shavini , Reid Natasha , Young Adrienne , Homes Ryan , Sia Aaron , Giddens Fiona , Francis Ross S. , Hubbard Ruth E. , Gordon Emily H. 
Published: October 2023

Background.
Clinical Practice Guidelines suggest that frailty be measured during kidney transplant eligibility assessments. Yet it is not known how frailty is best assessed in this setting or whether its assessment is acceptable to patients. We aimed to examine the construct validity and feasibility of Frailty Index (FI) assessment among patients attending a kidney transplant assessment clinic and to explore patients’ perspectives on frailty and the acceptability of its routine assessment.

Methods.
A 58-item FI was calculated for 147 clinic patients. Semistructured interviews were conducted with a subgroup of 29 patients. The FI was validated against normative FI characteristics (mean, distribution, limit), age, and the Estimated Post-Transplant Survival Score. Feasibility was assessed using descriptive statistics. Qualitative data were analyzed using reflexive thematic analysis.

Results.
The mean FI was 0.23 (±0.10, normal distribution, limit 0.53). FI increased with age and Estimated Post-Transplant Survival score. The FI was completed for 62.8% of eligible patients (147/234). The median completion time was 10 min, and completion rate (with no missing data) was 100%. Four themes were identified: perceptions of frailty, acceptability, perceived benefits, and risks of frailty measurement. Patients linked frailty with age and adverse outcomes, and most did not consider themselves frail. Patients reported that the FI was quick, simple, and efficient. They felt that frailty assessment is relevant to transplant eligibility and should be used to address potentially reversible factors.

Conclusions.
The FI demonstrated construct validity and was feasible and acceptable in this clinic setting. The challenge is ensuring that routine assessments lead to better care.
Structured, nurse-led ward rounds to improve interprofessional communication and optimize care of vascular surgery patients: a best practice implementation project
Authors: Neo Nicholas Wee Siong , Li Yao , Salazar Ailene Bandoy , Gan Jessica Kai Lun , Ng Jun Jie , Tho Poh Chi 
Published: October 2023

ABSTRACT

Introduction:
Ward rounds are crucial inpatient activities during which patients’ conditions are discussed. Team-based models such as nurse-led ward rounds (NLWRs) have been conceptualized and trialled, with positive results.

Methods:
An evidence-based quality improvement pilot project to introduce NLWRs was implemented at a cardiovascular medical-surgical unit in a Singapore tertiary hospital. The JBI Evidence Implementation Framework was used to guide the project. The evidence-based NLWR format incorporated stakeholder feedback on NLWR frequency, preparation, coordination, and content. Baseline and 6-month post-implementation audits were carried out.

Results:
The 4 audit criteria improved from baseline, reaching 100% compliance for criteria 1, 2, and 3 associated with interprofessional communication and collaboration. An improvement from baseline (30% to 46.7%) was also observed for criterion 4 on patient involvement during medical ward rounds. Moreover, there were improvements in clinical outcome data such as patient hospitalization length, “best medical therapy” rates, and inpatient complications. A statistically significant improvement in nurses’ confidence to lead discussions during medical rounds was also observed (p = 0.026).

Conclusions:
This project promoted greater compliance with NLWR criteria through audit and feedback cycles and the contextualization of implementation strategies. A well-supported program that prepares nurses for interprofessional communication also improves nurses’ confidence in team communication, bolstering their ability to provide high-quality patient care.
Downregulation ofLet-7miRNA promotes Tc17 differentiation and emphysema via de-repression of RORγt
Authors: Erice Phillip A. , Huang Xinyan , Seasock Matthew J. , Robertson Matthew J. , Tung Hui-Ying , Perez-Negron Melissa A. , Lotlikar Shivani L. , Corry David B , Kheradmand Farrah , Rodriguez Antony 
Published: October 2023

ABSTRACTEnvironmental air irritants including nanosized carbon black (nCB) can drive systemic inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema development. Thelet-7family of miRNAs is associated with IL-17-driven T cell inflammation, a canonical signature of lung inflammation. Recent evidence suggests thelet-7family is downregulated in patients with COPD, however, whether this repression conveys a functional consequence on emphysema pathology has not been elucidated. Here we show that overall expression of thelet-7miRNA clusters,let-7b/let-7c2andlet-7a1/let-7f1/let-7d, are reduced in the lungs and T cells of smokers with emphysema as well as in mice with cigarette smoke (CS)- or nCB-elicited emphysema. We demonstrate that loss of thelet-7b/let-7c2-cluster in T cells predisposed mice to exaggerated CS- or nCB-elicited emphysema. Furthermore, ablation of thelet-7b/let-7c2-cluster enhanced CD8+IL17a+T cells (Tc17) formation in emphysema development in mice. Additionally, transgenic mice overexpressinglet-7in T cells are resistant to Tc17 and CD4+IL17a+T cells (Th17) development when exposed to nCB. Mechanistically, our findings reveal the master regulator of Tc17/Th17 differentiation, RAR-related orphan receptor gamma t (RORγt), as a direct target oflet-7miRNA in T cells. Overall, our findings shed light on thelet-7/RORγt axis withlet-7acting as a molecular brake in the generation of Tc17 cells and suggests a novel therapeutic approach for tempering the augmented IL-17-mediated response in emphysema.
RhoGDI phosphorylation by PKC regulates its interaction with death receptor p75NTRto gate axon growth and neuron survival pathways
Authors: Ramanujan Ajeena , Li Zhen , Lin Zhi , Ibáñez Carlos F. 
Published: October 2023

AbstractAlthough transmembrane receptors engage multiple signaling pathways simultaneously, each pathway is typically investigated individually. How receptors juggle their interactions with different downstream effectors and the conditions under which distinct pathways are prioritized remains poorly understood. Here we show that the outcome of death receptor p75NTRsignaling is determined through competition of effectors for interaction with its intracellular domain, in turn dictated by the nature of the incoming ligand. While NGF induces release of RhoGDI through recruitment of RIP2, thus decreasing RhoA activity in favor of NFkB signaling, MAG induces PKC-mediated phosphorylation of the RhoGDI N-terminus, thus promoting its interaction with the juxtamembrane domain of p75NTR, disengaging RIP2, and enhancing RhoA activity in detriment of NF-kB. This results in growth cone collapse, stunted neurite outgrowth and apoptosis in cerebellar granule neurons. If presented simultaneously, MAG prevails over NGF. The NMR solution structure of the complex between the RhoGDI N-terminus and p75NTRjuxtamembrane domain reveals previously unknown structures of these proteins and clarifies the mechanism of p75NTRactivation. These results show how ligand-directed competition between RIP2 and RhoGDI for p75NTRengagement determine axon growth and neuron survival. Similar principles are likely at work in other receptors engaging multiple effectors and signaling pathways.
Technology as an enabler for securing tenure rights for the slum dwellers
Authors: Mukherjee Anindita , Gupta Ashish , Tiwari Piyush , Dhar Baisakhi Sarkar 
Published: October 2023

Purpose
Achieving tenure security is a global challenge impacting cities of the global south. The purpose of this paper is to evaluate the role of technology-enabled solutions as an enabler for the tenure rights of slum dwellers.

Design/methodology/approach
In this paper, we adopted a case study approach to analyze the use cases for technologies aiding India’s securitization of land tenure. The flagship state mission of Odisha, named the Jaga Mission, and that of Punjab, named BASERA – the Chief Minister’s Slum Development Program – were used as cases for this paper.

Findings
It was found that technologies like drone imagery and digital surveys fast-tracked the data collection and helped in mapping the slums with accuracy, mitigating human errors arising during measurement – a necessary condition for ensuring de jure tenure security. The adoption of a technology-based solution, along with a suitable policy and legal framework, has helped in the distribution of secure land titles to the slum dwellers in these states.

Originality/value
Odisha’s and Punjab’s journey in using technology to enable tenure security for its urban poor residents can serve as a model for the cities of the global south, dealing with the challenges of providing secure tenure and property rights.
How does management respond to stock price crashes?
Authors: Roy Suvra , Marshall Ben R. , Nguyen Hung T. , Visaltanachoti Nuttawat 
Published: October 2023

PurposeThe purpose of this study is to investigate (1) how managers respond to stock price crashes, (2) why they respond and (3) how their responses affect shareholders.Design/methodology/approachThis study employs a panel regression with various firm-level controls and firm- and year-fixed effects. The sample is comprised of 101,532 firm-year observations with 11,727 unique firms from 1950 to 2019. Using mutual fund flow redemption pressure as an exogenous variable to stock price crashes, the paper provides further evidence of the causality of documented findings.FindingsManagement becomes more focused on improving transparency, raising investment efficiency, reducing agency conflicts and regaining the trust of shareholders by investing in social capital and employee welfare. These actions increase firm value. This study also suggests that management undertakes these actions out of concern for their tenure of employment.Originality/valueThe catalysts of stock price crashes are well documented, but much less is known about what happens following stock price crashes. This study provides more insights into the understanding of corporate crisis management practices following adverse events.
Dialectic critical realism in business marketing: dialectic customer portfolio management
Authors: Vanharanta Markus , Wong Phoebe 
Published: October 2023

Purpose
This study aims to contribute to the field of customer portfolio management by proposing a novel approach rooted in dialectic critical realism (DCR). DCR, as an ontological theory, enables a fundamental reimagining of customer portfolio management as a dialectic process. The conceptualized dialectic portfolio management is motivated by the concept of “absence”, akin to Hegelian “antithesis”, which highlights limitations, problems and tensions in portfolio management. In essence, “absence” serves as a diagnostic tool that directs portfolio actions towards resolving problems by pursuing a more comprehensive “totality”, similar to the Hegelian notion of “synthesis”.

Design/methodology/approach
This conceptual paper theorizes DCR in business marketing and customer portfolio management.

Findings
DCR conceptualizes customer portfolios as relational structures characterized by omissions and tensions. These issues are addressed through a dialectic synthesis aimed at achieving a more comprehensive “totality”. Consequently, DCR guides portfolio management to continually re-think the connections and distinctions that define a portfolio within its network context. This dialectic process is facilitated by a novel vocabulary that enhances the understanding of network and portfolio relations, incorporating concepts such as “intrapermeations”, “existential constitutions”, “intra-connections” and “intensive” and “extensive” portfolio practices.

Originality/value
This study aims to foster a fresh and process-oriented perspective on portfolio management, drawing inspiration from the growing demand for enriched dialectic theorizing within the realm of business marketing. The adoption of a dialectic process orientation based on DCR revolutionizes the comprehension of portfolio management by fundamentally reimagining the underlying ontological assumptions that underpin the existing body of literature on customer portfolios. Moreover, DCR asserts that ethical considerations are inextricably linked to human experiences and associated practices, emphasizing ethics as an integral component of customer portfolio management.
Internal auditor's interpersonal trust building: the Israeli public sector
Authors: Eshet Yovav 
Published: October 2023

PurposeThis paper investigate the antecedents of the public sector's senior management in interpersonal trust relationships involving sceptical internal audits in public services administrations. This is fundamental for a positive audit, as it affects the auditing relationship and assures a sound public administration.Design/methodology/approachThe author surveyed 261 senior management from 24 Israel's local authorities (about 30%), representing large, medium and small administrations in Israel's North District.FindingsThe results indicate that senior management's antecedents to trust sceptically minded internal audits are positive for audit knowledge sharing. Findings also reveal that the internal auditor's ability, integrity and benevolence significantly impact senior management's trust. Whereas open communication does not significantly affect the senior management's propensity to trust, its satisfaction with its internal auditor fosters positive trust and support.Practical implicationsUnderstanding the antecedents of the senior public manager on internal audit benefits the audit outcomes. Albeit audit professional scepticism's interpersonal trust relationship with senior public manager influences the audit. Audits efficiently related to organisational culture and outcomes.Originality/valueA new practical model of senior management trust antecedents is presented for a more effective auditing system and public administration. The model is original, as no other empirical studies have yet dealt with senior management's trust in internal audits in the public sector.
Productive or non-productive? Negative performance feedback and firms' cost behaviors
Authors: Tian Meng , Hu Chuan 
Published: October 2023

PurposeThe purpose of this paper is to examine the influences of negative performance feedback on firms' cost behaviors including productive behaviors (i.e. R&D behaviors) and non-productive behaviors (i.e. selling behaviors and business entertainment behaviors), as well as to investigate the roles of ownership types and marketization.Design/methodology/approachA sample of Chinese manufacturing firms from 2007 to 2018 is analyzed employing multiple regression models.FindingsThe results show that negative performance feedback has a positive but not significant effect on R&D behaviors, while its effect on selling behaviors is significantly positive. Meanwhile, there is an inverted U-shaped relationship between negative performance feedback and business entertainment behaviors. Furthermore, when facing a performance dilemma, state-owned enterprises tend to adjust selling behaviors, while nonstate-owned enterprises pay more attention to business entertainment behaviors. In terms of marketization, the firms in high-marketization regions are more likely to adjust their R&D, selling and business entertainment behaviors, while the firms in low-marketization regions are difficult to adjust these cost behaviors.Practical implicationsThis study explores the role of negative performance feedback in firms' cost behaviors and provides empirical evidence about the differentiated influences regarding ownership types and marketization.Originality/valueIntegrating insights from existing studies and introducing the behavioral theory of the firm and prospect theory, this study proposes a more inclusive framework that addresses the impacts of negative performance feedback on firms' cost behaviors. This paper deepens the understanding of firms' decision behaviors in the dilemma of performance shortfall.
Complex infrastructure systems analysis and management: the theory of faults
Authors: Yonat Niv , Isaac Shabtai , Shohet Igal M. 
Published: October 2023

PurposeThe purpose of this research is to provide a theoretical and practical theory and application that provides understanding and means to manage complex infrastructures.Design/methodology/approachIn this research, complexity, nonlinear, noncontinuous effects and aleatoric and data unknowns are bypassed by directly addressing systems' responses. Graph theory, statistics and digital signal processing (DSP) tools are applied within a theoretical framework of the theory of faults (ToF). Motivational complex infrastructure systems (CISs) are difficult to model. Data are often missing or erroneous, changes are not well documented and processes are not well understood. On top of it, under complexity, stalwart analytical tools have limited predictive power. The aleatoric risk, such as rain and risk cascading from interconnected infrastructures, is unpredictable. Mitigation, response and recovery efforts are adversely affected.FindingsThe theory and application are presented and demonstrated by a step-by-step development of an application to a municipal drainage system. A database of faults is analyzed to produce system statistics, spatio-temporal morphology, behavior and traits. The gained understanding is compared to the physical system's design and to its modus operandi. Implications for design and maintenance are inferred; DSP tools to manage the system in real time are developed.Research limitations/implicationsSociological systems are interest driven. Some events are intentionally created and directed to the benefit and detriment of the opposing parties in a project. Those events may be explained and possibly predicted by understanding power plays, not power functions. For those events, sociological game theories provide better explanatory value than mathematical gain theories.Practical implicationsThe theory provides a thematic network for modeling and resolving aleatoric uncertainty in engineering and sociological systems. The framework may be elaborated to fields such as energy, healthcare and critical infrastructure.Social implicationsToF provides a framework for the modeling and prediction of faults generated by inherent aleatoric uncertainties in social and technological systems. Therefore, the framework and theory lay the basis for automated monitoring and control of aleatoric uncertainties such as mechanical failures and human errors and the development of mitigation systems.Originality/valueThe contribution of this research is in the provision of an explicatory theory and a management paradigm for complex systems. This theory is applicable to a wide variety of fields from facilities and construction project management to maintenance and from academic studies to commercial use.
Return Fantasies: Martial Masculinity, Misogyny and Homosocial Bonding in the Aftermath of Second World War
Authors: Garton Stephen 
Published: October 2023

AbstractThis article explores male popular culture in Australia in the mid‐1940s, particularly men's magazines of the period, to illuminate aspects of the psycho‐sexual dimensions of Australian veterans returning to civil society. The sexual landscape of Australian society had undergone considerable transformation, especially through an increasing sexualisation of popular culture in the 1920s and 1930s. This provided a context for considerable sexual anxiety and tension, especially in the context of numerous stories of Australian women consorting with American servicemen during the war. Men's popular culture, especially short fiction, where more lurid fantasies could play out, often depicted women as sexually voracious and duplicitous. Many of the short stories involved love triangles where the men were betrayed by women. But the resolution of these rivalries often pathologised women while preserving the male bonds of war. Homosocial bonds were a bulwark in the troubled transition from war to peace.
‘BEST FOR FOODIES’: Food, Digital Media and Planetary Gentrification
Authors: Joassart‐Marcelli Pascale , Bosco Fernando J. 
Published: October 2023

AbstractLeisure activities, including place‐based food experiences, have become central to defining urban identities and branding places. Mobile and affluent urbanites’ search for authentic and cosmopolitan experiences is increasingly guided by corporate digital media such as apps and websites that direct them to previously ignored working‐class, ethnic and immigrant neighborhoods, which are being discursively and materially reconfigured to meet their needs, in turn causing the displacement of long‐time residents. We examine the relationship between food and gentrification through the lens of digital media, suggesting that they play an important role in shaping urban experiences and cities. Specifically, we investigate narratives produced by popular digital food media, not least websites and apps providing restaurant ratings and reviews, and their relationship to ongoing patterns of gentrification in Buenos Aires, Los Angeles and Paris. Using mixed methods that combine census data with ‘hybrid fieldwork’ in online and offline foodscapes, we identify some spatial patterns and key characteristics of food‐driven gentrification, highlighting the aestheticization of everyday life and its significance in encouraging and legitimizing planetary gentrification.
Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin‐like peptide
Authors: Wei Yi , Zhou Xiao‐Lin , Chen Peng , Liu Tai‐Hang , Lu Cheng , Pan Min‐Hui 
Published: October 2023

AbstractThe ovary generally undergoes tissue remodeling during larval to pupal transition, which includes membrane degeneration and ovariole growth. At the same time, the hormones produced by insects significantly change during metamorphosis. However, the regulatory mechanism for ovarian development and hormones is not fully understood in insects. Herein, we found that matrix metalloproteinase 2 (MMP2) was highly expressed in the ovarian capsules and ovarioles, and the development was abnormal after knocking out MMP2 in Bombyx mori. The process of abnormal degradation of collagen I due to MMP2 deletion, which resulted in abnormal development of ovarioles and eggs, was analyzed in detail. The proteomics of ovaries in the MMP2‐knock out and wild type strains showed a critically significant difference in the expression of a protein, insulin‐like peptide (ILP). Additional analysis revealed significant alteration of ILP during ovarian development, and abnormal expression of ILP significantly affected ovarian development in vivo and MMP2 expression in vitro and in vivo. These results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP expression. Our study provides new insights into the regulatory mechanism of MMP2 and ovarian development in B. mori.