bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of feeding and eating disorders in 191 children according to psychiatric or gastroenterological recruitment: The PEDIAFED cohort study
Authors: Bertrand Valérie , Tavolacci Marie‐Pierre , Bargiacchi Anne , Leblanc Véronique , Déchelotte Pierre , Stordeur Coline , Bellaïche Marc 
Published: February 2024

AbstractObjectiveThe DSM‐5 classification introduced new Feeding and Eating Disorders (FED) diagnostic categories, notably Avoidant and Restrictive Food Intake Disorder (ARFID), which, like other FED, can present psychiatric and gastrointestinal symptoms. However, paediatric clinical research that focuses on children below the age of 12 years remains scarce. The aim of this study was first to investigate the clinical features of FED in a cohort of children, second to compare them according to their recruitment (gastroenterology or psychiatry unit).MethodThis non‐interventional retrospective cohort study analysed 191 patients in a French paediatric tertiary care centre (gastroenterology n = 100, psychiatry n = 91). The main outcome variables were clinical data (type of FED, BMI, nutritional support, chronic diseases, psychiatric comorbidities, sensory, sleep, language disorders, gastrointestinal complaints, adverse life events, family history). The outcome was defined by a Clinical Global Impression of Change‐score.ResultsFED diagnoses were ARFID (n = 100), Unspecified FED (UFED, n = 57), anorexia nervosa (AN, n = 33) and one pica/rumination. Mean follow‐up was 3.28 years (SD 1.91). ARFID was associated with selective and sensory disorders (p < 0.001); they had more anxiety disorders than patients with UFED (p < 0.001). Patients with UFED had more chewing difficulties, language disorder (p < 0.001), and more FED related to chronic disease (p < 0.05) than patients with ARFID and AN. Patients with AN were female, underweight, referred exclusively to the psychiatrist, and had more depression than patients with ARFID and UFED (p < 0.001). The gastroenterology cohort included more UFED, while the psychiatry cohort included more psychiatric comorbidities (p < 0.001). A worse clinical outcome was associated with ARFID, a younger age at onset (p < 0.001), selective/sensory disorders and nutritional support (p < 0.05).ConclusionARFID and UFED children were diagnosed either by gastroenterologists or psychiatrists. Due to frequently associated somatic and psychiatric comorbidities, children with FED should benefit from a multidisciplinary assessment and care.
Lessons learned from the spatiotemporal analysis of long‐term and time‐variable young water fractions of large central European river basins
Authors: Stockinger Michael Paul , Stumpp Christine 
Published: February 2024

AbstractThe transit time of precipitation entering a catchment and leaving it as streamflow spatiotemporally varies according to the flow paths that precipitation takes. However, investigating influences of hydrometeorological variables and catchment characteristics on time‐variable transit times is challenging due to the complex water flow through heterogeneous landscapes. Recent studies investigated the fraction of streamflow younger than approximately 3 months (Fyw) using multi‐year data (long‐term Fyw) or one‐year calculation windows to investigate its time‐variability (time‐variable Fyw). Nonetheless, it is still unclear if the inter‐annual variability of one‐year Fyw is due to hydrological influences or its uncertainty, and no minimum time series length for the long‐term Fyw was defined yet. Here, we investigated the impact of catchment characteristics and hydrometeorological variables on the long‐term Fyw, the time‐variable Fyw, and the Fyw depending on discharge of nine river basins in Central Europe. All methods of estimating Fyw led to similar results, with Fyw depending on discharge deemed unreliable due to the monthly sampling interval of streamflow isotopes. Danube and Rhine had the lowest Fyw (0.06), medium Fyw (0.20) were found in eastern basins (e.g., Oder), and the western ones (e.g., Mosel) had the highest Fyw (0.33). Spatial analysis indicated a negative relationship between Fyw and altitude. Contradicting or lacking spatiotemporal relationships to other variables pointed to unknown influential factors controlling the runoff process. Using flow duration curves, it was found that basins with a low flow variability had low Fyw, indicating that the old water of their runoff stems from large subsurface storage. With increasing calculation window size, the within‐basin variability of time‐variable Fyw decreased. Long‐term Fyw depended on the method used to define ‘long‐term’ and the time series length and start and end date. We thus recommend future studies to calculate long‐term and time‐variable Fyw to facilitate comparability between different catchments, and to account for this source of uncertainty. Further, more studies are needed in diverse catchments to investigate the hydrometeorological impacts on Fyw and thus on runoff generation processes.
Thermal conductivity in a vadose zone: A novel spectral solution and application by the implication of significant coherence of thermal condition in the shallow soil water layer
Authors: Shih David Ching‐Fang 
Published: February 2024

AbstractIn the context of the heterogeneity in the unsaturated or vadose zone, accurately representing the analytical mechanisms and in‐situ water content within the soil layer poses a significant challenge. Particularly in shallow layers, thermal conditions exhibit rapid changes in response to evolving surface temperatures. This study proposes a hypothesis suggesting that the in situ heat mechanism may notably impact the soil water layer. The research introduces an innovative approach to theoretically uncover thermal conditions, including soil temperature, soil temperature gradients, and heat flux, within the shallow Quaternary gravel layer at various depths through spectral analysis of temporal observations. The study presents a stochastic inverse solution to estimate thermal conductivity by leveraging spectral analysis of soil heat flux and temperature gradients. The findings reveal that thermal conditions exhibit the most prominent periodic fluctuations during the diurnal process over a 24‐hour cycle. The soil temperature gradients and heat flux measurements at depths of 0.1, 0.3, 0.6, and 1.2 m demonstrate their ability to capture changes in soil temperature and air temperature to a certain extent within the frequency domain. Furthermore, the analysis highlights the intrinsic uncertainty and sensitivity of estimating thermal conductivity in heterogeneous soil environments. The wide variability observed in thermal conductivity values, coupled with their dependence on soil type and environmental conditions, underscores the need for careful consideration of these factors in future studies and modeling efforts. Applying the derived inverse spectral solution allows for determining thermal conductivity throughout the soil‐water system across depths ranging from 0.1 to 1.2 m. As a result, this research demonstrates the feasibility and practicality of assessing the thermal conductivity of the soil layer in conjunction with heat flux and temperature gradients through spectral analysis.
Evidence for variations in cryogenic extraction deuterium biases of plant xylem water across foundational northeastern US trees
Authors: Sobota Matthew , Li Kevin , Hren Michael , Knighton James 
Published: February 2024

AbstractMeasurements of oxygen and hydrogen isotopes in plant xylem water (2H, 18O) have helped to redefine conceptual and numerical models of the hydrological cycle and understand how plants compete for subsurface water. Recent experiments have shown that Cryogenic Vacuum Extraction (CVE) of plant xylem water can result in a δ2H bias. We tested if CVE δ2H‐biases varied significantly across seven foundational northeastern US forest trees with a series of tree core rehydration experiments. Our analysis demonstrated that CVE δ2H‐biases were well predicted by sample gravimetric water content and varied significantly with tree species identity. We show that species‐level δ2H‐bias corrections can result in substantially different understandings of plant water uptake and transpiration versus uncorrected data or generic bias corrections. This research demonstrates an urgent need for the critical evaluation of CVE for plant water extraction. In the absence of a stronger understanding of CVE δ2H‐biases, we recommend that xylem water δ2H observations should not be used in plant water uptake studies.
The implications of non‐synchronous trading in G‐7 financial markets
Authors: Dimitriou Dimitrios , Kenourgios Dimitris , Simos Theodore , Tsioutsios Alexandros 
Published: February 2024

AbstractWe investigate the effects of non‐synchronous trading on volatility spillover for the G‐7 equity markets during the Eurozone sovereign debt crisis (ESDC) and the Covid‐19 pandemic crisis. For data synchronisation we utilise ΜΑ(1) adjusted return series to estimate the Baba‐Engle‐Kraft‐Kroner (BEKK) and the dynamic conditional correlation (DCC) models. We also consider the use of realised kernels as explanatory variables in the variance equation. In this set up, the contagion effects during crises periods are more perceptible, as the spikes are easier to interpret. We also check the robustness of our main results by applying, wavelet coherence analysis to G‐7 major equity indices with realised kernels, as well as local Gaussian correlations (LGC). Our findings suggest the empirical significance of the synchronisation effects for the US and the other G‐7 equity markets. We also conclude that realised kernels is an effective tool for mitigating non‐synchronous effects. These results underline the significance of quantifying the synchronisation effects in equity markets as well as international portfolio diversification strategies.
Palmitoylation is required for Sept8‐204 and Sept5 to form vesicle‐like structure and colocalize with synaptophysin
Authors: Liu Huicong , Tan Rong , Tong Jia , Wen Shuo , Wu Can , Rao Muding , Zhu Jiangli , Qi Shiqian , Kong Eryan 
Published: February 2024

AbstractSept8 is a vesicle associated protein and there are two typical transcriptional variants (Sept8‐204 and Sept8‐201) expressed in mice brain. Interestingly, the coexpression of Sept8‐204/Sept5 induces the formation of small sized vesicle‐like structure, while that of the Sept8‐201/Sept5 produces large puncta. Sept8 is previously shown to be palmitoylated. Here it was further revealed that protein palmitoylation is required for Sept8‐204/Sept5 to maintain small sized vesicle‐like structure and colocalize with synaptophysin, since either the expression of nonpalmitoylated Sept8‐204 mutant (Sept8‐204‐3CA) or inhibiting Sept8‐204 palmitoylation by 2‐BP with Sept5 produces large puncta, which barely colocalizes with synaptophysin (SYP). Moreover, it was shown that the dynamic palmitoylation of Sept8‐204 is controlled by ZDHHC17 and PPT1, loss of ZDHHC17 decreases Sept8‐204 palmitoylation and induces large puncta, while loss of PPT1 increases Sept8‐204 palmitoylation and induces small sized vesicle‐like structure. Together, these findings suggest that palmitoylation is essential for the maintenance of the small sized vesicle‐like structure for Sept8‐204/Sept5, and may hint their important roles in synaptic functions.
Characterization of a biosurfactant produced by Peruvian strain Pseudomonas aeruginosa 6K‐11
Authors: Obregon‐Maldonado Pepe Martin , Merino‐Rafael Fernando Abilio , Gutiérrez‐Moreno Susana Mónica 
Published: February 2024

AbstractBACKGROUNDThe oil industry has a big impact on the environment by itself and by using chemically synthesized surfactants. Biosurfactants are an ecofriendly alternative, especially rhamnolipids produced by Pseudomonas aeruginosa. Rhamnolipids in a determined concentration decrease the liquid surface tension, and this allows access oil hydrocarbon to be degraded. The objective of this research is to characterize the biosurfactant produced by the native strain P. aeruginosa 6K‐11 by determining its critical micelle concentration (CMC), Krafft point, and emulsifying activity.RESULTSExperiments were initially performed with rhamnolipid produced by P. aeruginosa 6K‐11 growing on Siegmund‐Wagner medium with 1% of waste oil as carbon source and at 31.26 °C, 186 rpm after 42 h of incubation. After that, the biosurfactant was purified according to acid precipitation methodology. The first conductivity measurement, 34 μS/cm, was obtained with 12.5 g/L of rhamnolipid by using an APERA conductivity meter. The rhamnolipid CMC was 5.86 g/L due to the conductivity measurements graph and 0.49 was the dissociation degree. The equations of both lines were found by the method of least squares. The rhamnolipid has produced 1.97 Units of Emulsifying Activity (UEA) and 50% stability was observed based on the E24 Index. The highest conductivity achieved under 39 °C, as calculated from a conductivity against temperature graph, was the Krafft point.CONCLUSIONThese findings give important parameters to characterize the P. aeruginosa 6K‐11 biosurfactant activity that can be used to accelerate oil biodegradation in bioremediation processes. © 2024 Society of Chemical Industry (SCI).
Anterior Cruciate Ligament‐Return to Sport after Injury (ACL‐RSI) subcategories are affected by subjective running ability and medial single‐leg hop distance in postreconstruction patients at 6 months
Authors: Aizawa Jun‐ya , Hirohata Kenji , Ohji Shunsuke , Mitomo Sho , Ohmi Takehiro , Koga Hideyuki , Yagishita Kazuyoshi 
Published: February 2024

AbstractPurposeThis study aimed to investigate the intricate relationship between physical function factors and each subcategory score of the Anterior Cruciate Ligament‐Return to Sport after Injury (ACL‐RSI) scale among patients following ACL reconstruction.MethodsParticipants comprised 59 patients who had undergone primary ACL reconstruction using hamstring tendon. The ACL‐RSI was completed 6 months after reconstruction and five physical functions were measured in patients on the same day. Simple linear regression was performed multiple times to investigate the relationship between ACL‐RSI subcategory scores as a dependent variable and each independent variable (knee strength, leg anterior reach distance, single‐leg hop [SLH] distances, side bridge endurance, and subjective running ability). Multiple regression analysis was performed using a stepwise method, with factors showing a risk rate <0.05 in simple linear regression analyses as independent variables and the ACL‐RSI in each subcategory score as the dependent variable.ResultsMultiple regression analysis showed that subjective running ability affected all subcategories (p ≤ 0.001), and that the limb symmetry index of medial SLH distance affected both the Emotions (p = 0.047) and Confidence (p = 0.009) subcategories. Higher subjective running ability and greater limb symmetry in the medial SLH were thus positively associated with each dimension of psychological readiness.ConclusionsThis study highlights the differential impact of physical function factors on specific subcategories of the ACL‐RSI scale, providing clinicians with insights for designing targeted rehabilitation strategies. This original paper suggests the importance of analysing factors related to subcategory scores in addition to total ACL‐RSI score, and could contribute to the understanding of determinants for a successful return to sport following ACL reconstruction.Level of EvidenceLevel IV.
Measuring the therapeutic bond in genetic counseling: Testing measurement error in the bond subscale of the Working Alliance Inventory
Authors: Broadbridge Elizabeth , Roter Debra L. , Persky Susan , Erby Lori H. 
Published: February 2024

AbstractThe therapeutic relationship is a key component of successful genetic counseling. In psychotherapy, a strong therapeutic relationship can improve patient health outcomes and a poor relationship can worsen psychological functioning. Investigation of the therapeutic relationship in genetic counseling has shown evidence for a similar pattern. Reliable measurement of the therapeutic relationship is necessary for consistency across studies in the genetic counseling context. One measure that has been adapted for use in genetic counseling is the Working Alliance Inventory (WAI). However, there have been no studies of the factor structure or item‐level method bias analyses for the genetic counseling‐adapted version of the WAI. The goal of this study was to test the factor structure of the WAI observer version (WAI‐O) bond subscale and assess method bias in a genetic counseling context. We hypothesized that differences in factor structures would exist for items that were positively (n = 9) versus negatively (n = 3) worded (reverse coded). Secondary data analysis was performed on two data sets that utilized the WAI‐O in genetic counseling contexts. Data set 1 used simulated genetic counseling sessions that were judged by analog clients recruited through crowdsourcing platforms (N = 861). Data set 2 was conducted with genetic counseling clients, and sessions were evaluated by a research team (N = 120). Principal axis factor analysis with oblique oblimin rotation supported a two‐factor solution for the WAI‐O bond subscale across data sets. Items factored based on wording, with the positively worded items loading together and the negatively worded items loading on the second factor. Confirmatory factor analyses supported the removal of all negatively worded items from the instrument across data sets. Results suggest that the negatively worded items on the WAI‐O may be capturing a construct inconsistent with the positively worded items and support rewording and/or excluding them from use for a more reliable measure of the therapeutic bond.
Emerging strategies and therapeutic innovations for combating drug resistance in Staphylococcus aureus strains: A comprehensive review
Authors: Gopikrishnan Mohanraj , Haryini Sree , C George Priya Doss 
Published: February 2024

AbstractIn recent years, antibiotic therapy has encountered significant challenges due to the rapid emergence of multidrug resistance among bacteria responsible for life‐threatening illnesses, creating uncertainty about the future management of infectious diseases. The escalation of antimicrobial resistance in the post‐COVID era compared to the pre‐COVID era has raised global concern. The prevalence of nosocomial‐related infections, especially outbreaks of drug‐resistant strains of Staphylococcus aureus, have been reported worldwide, with India being a notable hotspot for such occurrences. Various virulence factors and mutations characterize nosocomial infections involving S. aureus. The lack of proper alternative treatments leading to increased drug resistance emphasizes the need to investigate and examine recent research to combat future pandemics. In the current genomics era, the application of advanced technologies such as next‐generation sequencing (NGS), machine learning (ML), and quantum computing (QC) for genomic analysis and resistance prediction has significantly increased the pace of diagnosing drug‐resistant pathogens and insights into genetic intricacies. Despite prompt diagnosis, the elimination of drug‐resistant infections remains unattainable in the absence of effective alternative therapies. Researchers are exploring various alternative therapeutic approaches, including phage therapy, antimicrobial peptides, photodynamic therapy, vaccines, host‐directed therapies, and more. The proposed review mainly focuses on the resistance journey of S. aureus over the past decade, detailing its resistance mechanisms, prevalence in the subcontinent, innovations in rapid diagnosis of the drug‐resistant strains, including the applicants of NGS and ML application along with QC, it helps to design alternative novel therapeutics approaches against S. aureus infection.
Could the aroma of spices produce a cross‐modal enhancement of food saltiness and contribute to reducing salt intake?
Authors: Segura‐Borrego M. Pilar , Ubeda Cristina , Pastor Olga , Callejón Raquel M. , Morales M. Lourdes 
Published: February 2024

AbstractBACKGROUNDAs a result of its correlation with cardiovascular diseases, salt intake must be reduced. According to multi‐sensory integration, aroma plays an important role in saltiness enhancement; this could enable a food's salt content to be reduced without losing acceptance. We therefore studied the effect of three spices, Curcuma longa, Laurus nobilis L. and Petroselinum crispum L., on saltiness enhancement through sensory tests on consumers. This was followed by olfactometric analysis with the aim of relating the effect to the spices’ aromatic composition.RESULTSAccording to the odour‐induced salty taste enhancement (OISE) mean values, bay leaf and turmeric had the highest effect on saltiness enhancement, at a similar level to dry‐cured ham aroma, wherwas parsley had a significantly lower OISE value. Only one odour‐active compound (OAC), eugenol, showed a direct correlation with the spices' OISE values. Turmeric primarily had OACs with sweet aroma, whereas bay leaf had more OACs belonging to the spicy‐aroma category.CONCLUSIONThe three spices, turmeric, bay leaf and parsley, investigated in the present study appear to enhance the salty taste of mashed potato with a low salt content. The results suggest that an interaction effect among OACs with different aromatic ranges may exist. Therefore, when the global OAC modified frequency value, grouped according to aroma range, was considered, the sweet range appears to counteract the effect of the spicy aroma on saltiness. © 2024 Society of Chemical Industry.
Integrative metabolome and transcriptome profiling provide insights into elucidation of the synthetic mechanisms of phenolic compounds in Yunnan hulled wheat (Triticum aestivum ssp. yunnanense King)
Authors: Zhang Chuanli , Sha Yun , Wang Qianchao , Liu Junna , Zhang Ping , Cheng Shunhe , Qin Peng 
Published: February 2024

AbstractBACKGROUNDYunnan hulled wheat grains (YHWs) have abundant phenolic compounds (PCs). However, a systematic elucidation of the phenolic characteristics and molecular basis in YHWs is currently lacking. The aim of the study, for the first time, was to conduct metabolomic and transcriptomic analyses of YHWs at different developmental stages.RESULTSA total of five phenolic metabolite classes (phenolic acids, flavonoids, quinones, lignans and coumarins, and tannins) and 361 PCs were identified, with flavonoids and phenolic acids being the most abundant components. The relative abundance of the identified PCs showed a dynamic decreasing pattern with grain development, and the most significant differences in accumulation were between the enlargement and mature stage, which is consistent with the gene regulation patterns of the corresponding phenolic biosynthesis pathway. Through co‐expression and co‐network analysis, PAL, HCT, CCR, F3H, CHS, CHI and bZIP were identified and predicted as candidate key enzymes and transcription factors.CONCLUSIONThe results broaden our understanding of PC accumulation in wheat whole grains, especially the differential transfer between immature and mature grains. The identified PCs and potential regulatory factors provide important information for future in‐depth research on the biosynthesis of PCs and the improvement of wheat nutritional quality. © 2024 Society of Chemical Industry.