bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence and Machine Learning Applications in Sudden Cardiac Arrest Prediction and Management: A Comprehensive Review
Authors: Aqel Sarah , Syaj Sebawe , Al-Bzour Ayah , Abuzanouneh Faris , Al-Bzour Noor , Ahmad Jamil 
Published: October 2023

Abstract
Purpose of Review
This literature review aims to provide a comprehensive overview of the recent advances in prediction models and the deployment of AI and ML in the prediction of cardiopulmonary resuscitation (CPR) success. The objectives are to understand the role of AI and ML in healthcare, specifically in medical diagnosis, statistics, and precision medicine, and to explore their applications in predicting and managing sudden cardiac arrest outcomes, especially in the context of prehospital emergency care.

Recent Findings
The role of AI and ML in healthcare is expanding, with applications evident in medical diagnosis, statistics, and precision medicine. Deep learning is gaining prominence in radiomics and population health for disease risk prediction. There’s a significant focus on the integration of AI and ML in prehospital emergency care, particularly in using ML algorithms for predicting outcomes in COVID-19 patients and enhancing the recognition of out-of-hospital cardiac arrest (OHCA). Furthermore, the combination of AI with automated external defibrillators (AEDs) shows potential in better detecting shockable rhythms during cardiac arrest incidents.

Summary
AI and ML hold immense promise in revolutionizing the prediction and management of sudden cardiac arrest, hinting at improved survival rates and more efficient healthcare interventions in the future. Sudden cardiac arrest (SCA) continues to be a major global cause of death, with survival rates remaining low despite advanced first responder systems. The ongoing challenge is the prediction and prevention of SCA. However, with the rise in the adoption of AI and ML tools in clinical electrophysiology in recent times, there is optimism about addressing these challenges more effectively.
Bringing a Uniform Home: a Qualitative Study on Police Officer’s Work-Family Balance Perspective!
Authors: Sousa Bárbara , Mendes Gabriela , Gonçalves Tânia , Oliveira Carina , Figueiredo Maria João , Costa Patrício , Maia Ângela 
Published: October 2023

AbstractBeing a police officer is a very stressful job, characterized by occupational stressors that impact mental health and increasing work-family balance. Quantitative research is unable to clarify how police officers cope with the impact of work challenges on work-family balance. This study aims to understand how police officers narrate the impact of their work on their family experiences. Nineteen semi-structured interviews were conducted with Portuguese military police and civilian service forces working in the Northern region of Portugal. The interviews were transcribed and analyzed according to the principles of thematic analysis. The main themes indicate that participants are concerned about the work-family conflict. Both common and unique police officers’ perceptions of the impact of professional challenges on work-family balance emerged among both groups. Common work-family balance challenges for both civilian and military police officers included a negative impact on family dynamics and the sharing work experiences with family, but also recognized positive impacts of the profession on the family. For military police officers, making decisions regarding career advancement is a specific challenge. This study enables clinicians and other professional groups, such as commanders and politicians, to further develop a deeper understanding of these challenges and their different levels of impact. It also allows for the development of targeted strategies aligned with the unique needs of these professionals.
Methylamphetamine toxicity and its involvement in death: A retrospective observational study of deaths reported to the Victorian Coroner, Australia
Authors: Mantinieks Dylan , Archer Melanie , Schumann Jennifer , Drummer Olaf H. , Gerostamoulos Dimitri 
Published: October 2023

AbstractA retrospective observational study of Victorian deaths involving MA between 2010 and 2019 was conducted to determine the prevalence and contribution of methylamphetamine (MA) toxicity to death in the absence of other factors. Demographics, autopsy findings, toxicology, and the cause of death were reviewed. Coronial cases were categorized into five groups: deaths due to MA toxicity in the absence of other factors (Group A1); deaths due to MA toxicity in the setting of other potentially contributing factors (Group A2); deaths due to MA toxicity in the setting of significant natural disease (Group B); deaths primarily due to multiple-drug toxicity (Group C); and deaths primarily due to natural causes (Group D). There were 506 deaths involving MA categorized into Group A1 (n = 1, 0.6%), Group A2 (n = 8, 1.6%), Group B (n = 28, 5.5%), Group C (n = 229, 45%), and Group D (n = 240, 47%). Significant natural disease was prevalent among deaths involving MA and mainly concerned forms of cardiovascular disease (n = 277, 55%). The MA concentration in the one death included in Group A1 was 2.1 mg/L. The median MA concentrations of Group A2 (1.6 mg/L) and Group B (0.5 mg/L) were significantly higher than Group C (0.2 mg/L) and Group D (0.2 mg/L). Additionally, many other toxicologically significant drugs were detected and mostly comprised of central nervous system depressants. Deaths due to MA toxicity in the absence of other factors were rare despite the greater availability of crystal MA in the Australian community. The study highlights the interpretative challenges of MA blood concentrations and the continuing harms of this drug in Australia.
Identification of Regulatory Elements in Primary Sensory Neurons Involved in Trauma-Induced Neuropathic Pain
Authors: Stephens Kimberly E. , Moore Cedric , Vinson David A. , White Bryan E. , Renfro Zachary , Zhou Weiqiang , Ji Zhicheng , Ji Hongkai , Zhu Heng , Guan Yun , Taverna Sean D. 
Published: October 2023

AbstractChronic pain is a significant public health issue that is often refractory to existing therapies. Here we use a multiomic approach to identify cis-regulatory elements that show differential chromatin accessibility and reveal transcription factor (TF) binding motifs with functional regulation in the rat dorsal root ganglion (DRG), which contain cell bodies of primary sensory neurons, after nerve injury. We integrated RNA-seq to understand how differential chromatin accessibility after nerve injury may influence gene expression. Using TF protein arrays and chromatin immunoprecipitation-qPCR, we confirmed C/EBPγ binding to a differentially accessible sequence and used RNA-seq to identify processes in which C/EBPγ plays an important role. Our findings offer insights into TF motifs that are associated with chronic pain. These data show how interactions between chromatin landscapes and TF expression patterns may work together to determine gene expression programs in rat DRG neurons after nerve injury.
Three-month life expectancy as inclusion criterion for clinical trials in advanced pancreatic cancer: is it really a valid tool for patient selection?
Authors: Weiss Lena , Heinemann Volker , Fischer Laura E. , Gieseler Frank , Hoehler Thomas , Mayerle Julia , Quietzsch Detlef , Reinacher-Schick Anke , Schenk Michael , Seipelt Gernot , Siveke Jens T. , Stahl Michael , Vehling-Kaiser Ursula , Waldschmidt Dirk T. , Dorman Klara , Zhang Danmei , Westphalen C. Benedikt , von Bergwelt-Baildon Michael , Boeck Stefan , Haas Michael 
Published: October 2023

Abstract
Purpose
To analyze the 3-month life expectancy rate in pancreatic cancer (PC) patients treated within prospective trials from the German AIO study group.

Patients and methods
A pooled analysis was conducted for patients with advanced PC that were treated within five phase II/III studies conducted between 1997 and 2017 (Gem/Cis, Ro96, RC57, ACCEPT, RASH). The primary goal for the current report was to identify the actual 3-month survival rate, a standard inclusion criterion in oncology trials.

Results
Overall, 912 patients were included, 83% had metastatic and 17% locally advanced PC; the estimated median overall survival (OS) was 7.1 months. Twenty-one percent of the participants survived < 3 months, with a range from 26% in RC57 to 15% in RASH. Significant predictors for not reaching 3-month OS were > 1 previous treatment line (p < 0.001) and performance status (p < 0.001).

Conclusions
Despite the definition of a life expectancy of > 3 months as a standard inclusion criterion in clinical trials for advanced PC, a significant proportion of study patients does not survive > 3 months.

Trial registration numbers
NCT00440167 (AIO-PK0104), NCT01729481 (RASH), NCT01728818 (ACCEPT).
Organized crime involvement in antiquities looting in Italy
Authors: Balcells Marc 
Published: October 2023

AbstractTombaroli (the Italian name for looters of archaeological heritage) have criminally preyed on Italy’s ancient tombs for centuries. Criminological research on archaeological looting in Italy, however, is scarce. This research focused on the nature of the relationship between tombaroli and organized crime groups in Italy: a misrepresented relationship, as some media outlets depict looters as involved with organized crime. This research project drew on a multidisciplinary body of literature on Italian archaeological looting and interviews with looters, law enforcement officials, archeologists, prosecutors, and journalists, among others. It demonstrated that Italian archaeological looting is not a problem of organized crime. The study concluded that, presently, the relationship between looters and traditional Italian criminal organizations is anecdotal at best, nor currently looters could be considered organized criminals but rather criminals that need a certain level of organization to operate.
Belowground growth strategies of native and invasive rhizomatous perennial grasses in response to precipitation variability, clipping, and competition
Authors: Bam Surendra , Ott Jacqueline P. , Butler Jack L. , Xu Lan 
Published: October 2023

AbstractInvasive clonal species may exhibit different growth strategies than their native clonal competitors. In this study, we examined the spatial distribution of tiller outgrowth and the bud bank by comparing the investment in phalanx versus guerilla growth of a native and invasive perennial grass in North America. We also examined the effect of altered precipitation frequency, clipping, and competition on their clonal growth strategies. Investment in phalanx and guerilla growth was assessed by examining live propagule and tiller production from the plant crown versus its rhizomes. Although invasive Bromus inermis and native Pascopyrum smithii exhibited similar clonal growth strategies as young seedlings, their clonal growth strategies significantly differed by the end of their first growing season. Pascopyrum smithii invested in dual phalanx and guerilla tiller outgrowth and bud placement, and B. inermis primarily invested in phalanx tiller outgrowth and bud placement. Competition rather than intra-annual precipitation variability and clipping altered the clonal growth strategy of these species. Intra- and inter- specific competition did not alter tiller outgrowth for either species. However, inter-specific competition caused both species to alter their bud placement. Bromus inermis shifted more buds from phalanx to guerilla positions while P. smithii shifted in the opposite direction. This may enable invasive B. inermis to expand while confining native P. smithii to more localized areas in the future. Clonal growth strategies appear to be species specific and responsive to inter-specific competition. Investigating the belowground bud aspect of clonal growth can reveal the mechanism driving the future aboveground clonal growth strategy of native and invasive rhizomatous grasses and help inform the patterns of invasion within a plant community.
Histological spatial analysis on the induction of PD-L1+ macrophages by CD8+ T cells at the marginal microenvironment of triple-negative breast cancer
Authors: Suzuki Kazushi , Ohe Rintaro , Kabasawa Takanobu , Kitaoka Takumi , Kawai Masaaki , Motoi Fuyuhiko , Futakuchi Mitsuru 
Published: October 2023

Abstract
Background
Programmed death-ligand 1 (PD-L1) plays important roles in the evasion of antitumor immunity. Because we observed the localization of PD-L1-positive (PD-L1+) cells in the marginal region of triple-negative breast cancer (TNBC) specimens, we hypothesized that the marginal microenvironment of TNBC would involve the induction of PD-L1+ cells.

Methods
One hundred and one TNBC surgical specimens were examined. We performed immunohistochemical (IHC) studies of PD-L1, CD68, CD8, and pan-cytokeratin in these specimens. We analyzed the localization of IHC-positive cells and the distance between these cells by histological spatial analysis.

Results
In 30.7% of TNBC specimens, PD-L1+ cells were located in the marginal region. Approximately three PD-L1+ cells accumulated around a single TNBC cell. Most PD-L1+ cells were located within 50 μm of TNBC cells. PD-L1+ cells were indicated to interact with TNBC cells in the marginal region. PD-L1+CD68+ cells were located in the marginal region, while CD68+ macrophages (MΦs) were observed either in the marginal region or the core region. PD-L1 expression in MΦs was induced in the marginal region. The colocalization of CD8+ T cells in the marginal region indicates that PD-L1 expression in MΦs would be induced by interaction with CD8+ T cells. Because CD8+ T cells are positive for CCL2, CCL2 may induce PD-L1 expression in MΦs.

Conclusion
At the marginal microenvironment of TNBC, PD-L1 expression would be induced in MΦs by interaction with CD8+ T cells through CCL2. The interaction between PD-L1+ MΦs and TNBC cells would facilitate the growth of TNBC under antitumor immunity. These interactions would be potential targets for restoring antitumor immunity and suppressing TNBC progression.
Measuring the Relationship Between the 2019 Title X Final Rule and Patients’ Sexual and Reproductive Health Care Access and Behavior in Iowa Using a Difference-in-Difference Approach
Authors: Kavanaugh Megan L. , Leong Ellie , Haas Madeleine 
Published: October 2023

Abstract
Introduction
Previous research has documented how the implementation of the 2019 Title X Final Rule reduced the Title X network capacity and led to decreases in patient numbers. Our objective was to examine the relationship between the Rule and patients’ reproductive health care access and outcomes.

Methods
Our analysis draws on panel data from patients recruited when seeking publicly funded family planning care in Iowa between May 2018 and February 2019 who completed a baseline survey and agreed to be contacted for follow-up surveys at 6-, 12-, 18-, and/or 24-month intervals. We employ a difference-in-difference (DiD) approach, comparing reproductive health outcomes (access to care and contraceptive use) of respondents who had recently received care at sites that eventually left the Title X system following the Rule, the exposed group, to outcomes among those who had recently received care at sites that did not shift from being in the Title X system to exiting it, the control group, both before and after its implementation.

Results
After adjusting for respondents’ demographic characteristics in the DiD models, we found that those in the exposure group were 11% less likely to have received recent contraceptive care compared to respondents in the control group after the implementation of the Title X Final Rule when examining the full study period (p < .01). When examining only the pre-COVID 19 time period, we found that respondents in the exposure group were 13% less likely to have been using a provider-involved method (p < 0.01), 11% less likely to have been using a method that carries a cost (p < 0.05), and 18% less likely to report being satisfied with their method (p < 0.001) compared to respondents in the control group.

Conclusions
Using Iowa as a case study to understand how the 2019 Title X Final Rule may have changed family planning patients’ sexual and reproductive health outcomes, we found evidence of a negative association of the Rule with patients’ access to, and use of, contraception.

Policy Implications
These findings expand the evidence base of the influence of the 2019 Title X Final Rule on the Title X health care system and its capacity to provide SRH care by highlighting the trickle-down effects of the Rule on patients themselves. Policies that restrict access to any aspect of sexual and reproductive health care, including contraception and abortion, are in direct conflict with people’s realization of reproductive autonomy.
Maximal Number of Repetitions at Percentages of the One Repetition Maximum: A Meta-Regression and Moderator Analysis of Sex, Age, Training Status, and Exercise
Authors: Nuzzo James L. , Pinto Matheus D. , Nosaka Kazunori , Steele James 
Published: October 2023

AbstractThe maximal number of repetitions that can be completed at various percentages of the one repetition maximum (1RM) [REPS ~ %1RM relationship] is foundational knowledge in resistance exercise programming. The current REPS ~ %1RM relationship is based on few studies and has not incorporated uncertainty into estimations or accounted for between-individuals variation. Therefore, we conducted a meta-regression to estimate the mean and between-individuals standard deviation of the number of repetitions that can be completed at various percentages of 1RM. We also explored if the REPS ~ %1RM relationship is moderated by sex, age, training status, and/or exercise. A total of 952 repetitions-to-failure tests, completed by 7289 individuals in 452 groups from 269 studies, were identified. Study groups were predominantly male (66%), healthy (97%), < 59 years of age (92%), and resistance trained (60%). The bench press (42%) and leg press (14%) were the most commonly studied exercises. The REPS ~ %1RM relationship for mean repetitions and standard deviation of repetitions were best described using natural cubic splines and a linear model, respectively, with mean and standard deviation for repetitions decreasing with increasing %1RM. More repetitions were evident in the leg press than bench press across the loading spectrum, thus separate REPS ~ %1RM tables were developed for these two exercises. Analysis of moderators suggested little influences of sex, age, or training status on the REPS ~ %1RM relationship, thus the general main model REPS ~ %1RM table can be applied to all individuals and to all exercises other than the bench press and leg press. More data are needed to develop REPS ~ %1RM tables for other exercises.
Islandness and the European Court of Human Rights: Marooning Rights on Islands?
Authors: Tsampi Aikaterini 
Published: October 2023

AbstractSome 80 million people live on European islands. It thus comes as no surprise that a number of cases brought before the European Court of Human Rights developed on and/or pertain to islands. What is surprising, though, is that this jurisprudential corpus has not been explored with a view to assessing whether islandness has or should have a role in the implementation of the European Convention on Human Rights on islands. The present paper contemplates the strengths of an islandness-based approach in the implementation of human rights through the mapping of the weaknesses, the potentials and the lost opportunities in the case law of the Court with respect to such an approach. In this context, findings from the field of Island Studies are also considered. By focusing on the ECHR habitat, the present paper exemplifies, in particular, the untapped potential of an islandness-based approach in the development of international human rights law in general.
Emotions Online: Exploring Knowledge Workers’ Emotional Labour in a Digital Context in an Agile IT Company
Authors: Pultz Sabina , Dupret Katia 
Published: October 2023

AbstractDigital technologies and new ways of organising transform the way we experience work. This paper seeks to contribute to our understanding of the role of digital emotional labour (EL) among knowledge workers. We investigate the EL involved in digital communication practices among co-located knowledge workers employed in an agile IT-consultancy firm with a relatively flat hierarchy. Based on rich qualitative data, we analyse how the specific socio-material infrastructures of a democratic communication technology called ‘Flowdock’ give rise to EL (Hochschild inAmerican Journal of Sociology, 85(3), 551–575, 1979, University of California Press, 1983). The study contributes theoretically by developing work on EL in a digital context by engaging with Oudshoorn’s (Sociology of Health & Illness, 31(3), 390–405, 2009) term ‘digital proximity’. This implies opening up EL to a more dynamic and situated approach and contributing to the organisational research scrutinising the EL of backstage professionals. The paper concludes that online communication creates new demands of managing emotions in relation to 4 themes key to agile organising: (1) working as whole persons, (2) creating partnerships, (3) unclear decision-making and lastly (4) informal power dynamics. We discuss implications of the overall finding that knowledge workers face increased demands mixing social and technical skills.
A Metastasis of Ovarian Cancer in the Bartholin Gland: A Case Report with Systematic Literature Review
Authors: Olmes Gregor Leonhard , Breitbach Georg Peter , Tepikin Anton , Nistor Adriana , Solomayer Erich Franz , Hamoud Bashar Haj 
Published: October 2023

AbstractThe metastasis of a gynecological malignancy to the Bartholin gland is rare. We report the case of a 62-year-old patient who had undergone extensive treatment of metastatic ovarian cancer that involved the liver, spleen, and peritoneum. She presented with painful swelling of the left vulva. Clinical and sonographic examinations showed a solid tumor in loco typico of the Bartholin gland. Surgical excision was performed. The patient died 3 months after the diagnosis of this metastasis. We performed a systematic search of PubMed, which yielded 453 entries. We selected those with at least an abstract available in English that described metastatic lesions on the Bartholin gland (n = 5). The review showed that a variety of primary cancers (colorectal, medullary thyroid, breast cancer, and endometrial cancers) metastasize to this location. Some patients showed signs of visceral metastasis. Bartholin gland metastases appeared as initial and metachronous manifestations. Most patients were symptomatic, with painful swelling or abscess. Genetic alterations were mentioned in some cases. The main pathways of metastasis discussed were lymphatic, but the mechanism of such metastasis remains unclear. Surgical resection was the preferred treatment option. The literature review indicated that Bartholin gland metastasis of ovarian cancer is rare and associated with poor prognosis. Oncological reasons for vulvar pathologies should be taken into consideration in patients with metastases.