bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is ongoing testosterone required after pubertal induction in Duchenne muscular dystrophy?
Authors: Wood Claire L , Hollingsworth Kieren G , Bokaie Edrina , Hughes Eric , Muni-Lofra Robert , Mayhew Anna , Mitchell Rod T , Guglieri Michela , McElvaney Joseph , Cheetham Timothy D , Straub Volker 
Published: September 2023

Glucocorticoids (GCs) reduce inflammation and preserve muscle function in boys with Duchenne muscular dystrophy (DMD) but cause pubertal delay. Pubertal induction with testosterone is recommended but longer-term outcome is unknown.

Objective
To assess hypothalamic–pituitary–gonadal axis, muscle volume and function 5 years after pubertal induction.

Methods
A prospective observational follow-up of a clinical study was conducted. 15 GC-treated males with DMD were treated with incremental testosterone for 2 years (end of regimen +2 years) then evaluated at +2.5 years and +5 years (final follow-up ~3 years after last injection). Data collected included testicular volume (TV), gonadotrophin, testosterone, inhibin B, muscle function, and limb muscle MRI.

Results
Participants were 18.7 years (s.d. 1.6) at the final follow-up and had been on GC for 11.2 years (s.d. 2.2). Testosterone levels were similar at +2.5 years (8.6 nmol/L (s.d. 3.4) and 5 years (11.0 nmol/L (s.d. 6.1). TV increased from 2.8 mL (s.d. 0.9) at +2 years to 7.1 mL (s.d. 1.8) then 10.6 mL (s.d. 3.5) at +2.5 years and +5.0 years (P < 0.001). Inhibin B levels increased from 55.6 pg/mL (s.d. 47.0) at baseline to 158.2 pg/mL (s.d.87.6), P =0.004 at 5 years but remained lower than reference values (mean 305 pg/mL). Muscle contractile bulk decreased.

Interpretation
Pubertal induction with testosterone in DMD is associated with HPG axis activation and ongoing increases in inhibin B, TV, and testosterone concentrations. Some patients have normal levels which is promising regarding future fertility. Given the beneficial impact of testosterone on bone health, muscle, and well-being, monitoring testosterone levels in this population and supplementation of sub-optimal levels is important.
Invasive Bacterial Infections in Children With Sickle Cell Disease: 2014–2019
Authors: Gaschignard Jean , Koehl Bérengère , Rees David C. , Rincón-López Elena , Vanderfaeillie Anna , Pascault Alice , Allali Slimane , Cela Elena , Odièvre Marie-Hélène , Hau Isabelle , Oliveira Marisa , Guillaumat Cécile , Brousse Valentine , de Montalembert Mariane , Navarro Gómez Maria Luisa , Beldjoudi Naima , Bardon-Cancho Eduardo Jesus , Epalza Cristina ,   BACT-SPRING study group, Benkerrou Malika , Gaschignard Jean , Koehl Berengère , Pascault Alice , Brousse Valentine , Allali Slimane , de Montalembert Marianne , Odièvre Marie-Hélène , Hau Isabelle , Guillaumat Cécile , Blais Sophie , Runel-Belliard Camille , Pellegrino Béatrice , Malric Aurore , Guitton Corinne , Gouraud François , Petras Marie , Bensaid Philippe , Basmaci Romain , Eyssette-Guereau Stéphanie , Pham Luu-Ly , Bardon-Cancho Eduardo J. , Cela Elena , Gómez Maria Luisa Navarro , Rincon-Lopez Elena , Ruiz-Llobet Anna , Adan Rosa , Puyo Pablo Velasco , Recasens Valle , Epalza Cristina , Perez-Alonso Vanesa , Torrent Montserrat , Gomez Amanda Bermejo , Vázquez Angeles , Rodríguez Raquel Portugal , Alfaridi Huda , Almaghrabi Rana , Hoyoux Marie , Vanderfaeillie Anna , Oliveira Marisa , Ferreira Teresa , Rees David 
Published: September 2023

BACKGROUND
Children with sickle cell disease (SCD) are at a high risk of invasive bacterial infections (IBI). Universal penicillin prophylaxis and vaccination, especially against Streptococcus pneumoniae, have deeply changed its epidemiology. Analysis of IBI in children with SCD in a post-13-valent pneumococcal vaccine era is limited.

METHODS
Twenty-eight pediatric hospitals from 5 European countries retrospectively collected IBI episodes in SCD children aged 1 month to 18 years between 2014 and 2019. IBI was defined as a positive bacterial culture or polymerase chain reaction from a normally sterile fluid: blood, cerebrospinal, joint, or pleural fluid and deep surgical specimen.

RESULTS
We recorded 169 IBI episodes. Salmonella spp. was the main isolated bacteria (n = 44, 26%), followed by Streptococcus pneumonia (Sp; n = 31, 18%) and Staphylococcus aureus (n = 20, 12%). Salmonella prevailed in osteoarticular infections and in primary bacteremia (45% and 23% of episodes, respectively) and Sp in meningitis and acute chest syndrome (88% and 50%, respectively). All Sp IBI occurred in children ≤10 years old, including 35% in children 5 to 10 years old. Twenty-seven (17%) children had complications of infection and 3 died: 2 because of Sp, and 1 because of Salmonella. The main risk factors for a severe IBI were a previous IBI and pneumococcal infection (17 Sp/51 cases).

CONCLUSIONS
In a post-13-valent pneumococcal vaccine era, Salmonella was the leading cause of bacteremia in IBI in children with SCD in Europe. Sp came second, was isolated in children ≤10 years old, and was more likely to cause severe and fatal cases.
Rheology and sensory properties of microencapsulated propolis-enriched stirred-type yogurt
Authors: Taşdemir Yasemin , Gölge Evren 
Published: September 2023

In this study, the rheological, sensory and syneristic properties of yogurt enriched with 0.5%, 1% and 2% microencapsulated propolis (MP) was investigated. The viscosity measurements of stir-type yoghurt were performed with Brookfield DV-II viscometer. Shear rate varying between 0.02 s-1 and 100 s-1 flow models was obtained for rising and descending curves with the Rheocalc v3.3 software. Three flow models—Power Law, Herschel–Bulkley, and Casson models—were evaluated. All samples used in this analysis showed non-Newtonian and pseudoplastic properties. During the 21-day storage period, the Power Law flow model was optimal.
Understanding Antecedent Components of Social Entrepreneurship in Relation to Entrepreneurship and Family Business
Authors: Vargas Zeledon Aaron A. 
Published: September 2023

Background: This conceptual paper advance the understanding between the fields of entrepreneurship and family business to social entrepreneurship derived from studies which expose the existence of meaningful antecedent components moving closer to each other in the direction of social entrepreneurship.
Research design and methods: This paper presents a theoretical framework of five antecedent components that emerge as an active ground of practice and research based in a systematic literature review using different works published in scientific journal.
Results: Social entrepreneurship within the last three decades, in spite of its rising acceptance, scholars are far from touching a defined consensus concerning their valuable impact. This paper sheds light on the understanding and offer a novel establishment of knowledge, which enlarges the social entrepreneurship domain.
Conclusions: Yet little research elucidates the mechanisms addressing the antecedent components. In this aspect, examining the link that exist between entrepreneurship and family business will augment the social entrepreneurship domain enabling future research to consolidate the impact of the discipline.
Joaquín Varela Suanzes y la construcción de la Historia Constitucional como disciplina
Authors: Fernández Sarasola Ignacio 
Published: September 2023

Joaquín Varela no sólo fue autor de una extensa producción científica, sino que realizó una contribución decisiva al intento de convertir a la historia constitucional en una disciplina autónoma. A su parecer, la historia constitucional era un campo científico en el que confluían la historia contemporánea, el derecho constitucional, la historia del pensamiento político y la filosofía del derecho. Sus aportaciones metodológicas, así como la creación de revistas, editoriales y centros de investigación dedicados a la historia constitucional persiguieron ese objetivo de crear una nueva disciplina científica.
Enviado el (Submission Date): 12/03/2023
Aceptado el (Acceptance Date): 25/04/2023
Joaquín Varela y la historia del constitucionalismo: Mucho más que una cuestión de nombres y método
Authors: Álvarez Alonso Clara 
Published: September 2023

Por méritos propios Joaquín Varela Suanzes-Carpegna es reconocido como uno de los fundadores de la Historia del constitucionalismo en España. Sus contribuciones al respecto han adquirido una proyección internacional y han sido elogiadas por los más conspicuos especialistas europeos e iberoamericanos. En este trabajo se quiere subrayar la validez y originalidad de una producción construida sobre los presupuestos de la comparación y la contextualización, la apertura y colaboración con otras disciplinas jurídicas y extrajurídicas, la superación de los límites dogmáticos y temporales y los confesados fines de la materia. En especial en lo que referente a la construcción de una historia constitucional europea que supere los rígidos esquemas de los nacionalismos, pero sin olvidar las características y peculiaridades de las historias constitucionales propias.
Enviado el (Submission Date): 28/03/2023
Aceptado el (Acceptance Date): 27/04/2023
Joaquín Varela y la conversión de su vida en una pasión por la historia constitucional
Authors: Álvarez Álvarez Leonardo 
Published: September 2023

El trabajo analiza algunos aspectos de la carrera profesional de Joaquín Varela, profesor de derecho constitucional de la Universidad de Oviedo. Su labor en las aulas de la Facultad de Derecho, su trayectoria en el Departamento de Derecho Público, y el periodo investigador en el final de su vida.

Enviado el (Submission Date): 28/03/2023
Aceptado el (Acceptance Date): 27/04/2023
A case study of bowel prolapses after induced abortion
Authors: Agrawal Neha , Malik Neeru , Dabas Richa 
Published: September 2023

Induced abortion, the intentional termination of pregnancy, is among the most common of gynaecological procedures. Depending on country-specific abortion laws, where abortion laws are highly restrictive, abortion is unsafe leading to maternal morbidity and mortality. This is a case study of unsafe abortion. In this case a 25-year-old G3P2L2 with previous 2 normal vaginal delivery had uterine perforation with bowel prolapse through the vagina following an dilatation and curettage of a missed abortion of 7 week and 6 days in a private hospital. Following the procedure patient had severe abdominal pain and bleeding from vagina, magnetic resonance imaging (MRI) was done. Patient came to our hospital with MRI. Patient was taken for exploratory laparotomy with uterine repair, bowel resection and anastomosis. Even though MTP Amendment act 2021 in India is liberal and government provides free contraception and abortion services by trained personnel, due to ignorance and misinformation, female often undergoes unsafe abortion. Unsafe abortion causes mild discomfort to grave injury like bowel prolapse leading to maternal death. Best preventive measure is awareness and easy accessibility.
Uso de substâncias psicoativas entre adolescentes escolares de Distritos Municipais
Authors: Dantas de Sousa Larissa Maria , Aragão Joyce Mazza Nunes , Azevedo de Sousa Francisco Matheus , Nazaré Oliveira Eliany , De Almeida Paulo César , Mazza Nunes Bezerra Soleane 
Published: September 2023

Objetivo: analisar o uso de substâncias psicoativas entre adolescentes escolares. Método: estudo transversal, de abordagem quantitativa, realizado em 2021, com 199 alunos de quatro escolas estaduais de Ensino Médio localizadas nos Distritos de um Município do interior do Ceará. Utilizou-se um questionário autoaplicável, DUSI (Drug Use Screening Inventory). Resultados: 92 (46,2%) alunos cursavam o 1° ano do ensino médio, eram do sexo feminino 114 (57,3%), com idade predominante de 15 a 16 anos (N 31 65,9%). Os adolescentes relataram o uso de todas substancias pesquisadas, mesmo que fosse somente de uma a duas vezes no último mês. Foram prevalentes: analgésicos (15,6%), álcool (14,5%), tranquilizantes (4,5%) e maconha (2,5%). Quase totalidade dos participantes negou o uso de tabaco nos últimos 30 dias. A maioria dos participantes negou ter problemas associados ao uso dessas substâncias psicoativas Conclusão: o estudo auxiliou na compreensão das substâncias psicoativas mais consumidas entre os alunos do Ensino Médio de Distritos Municipais, permitindo ampliar os conhecimentos sobre o uso de drogas no ambiente escolar. Esse achado demonstra a presença dessas substâncias e o uso entre os adolescentes mesmos nos locais mais distantes dos grandes centros urbanos.
A inter-relação entre os espaços livres e os recursos hídricos urbanos: uma revisão sistemática da literatura
Authors: Torres Thaís Ferreira , Oliveira Daniela Bogado Bastos , Oliveira Vicente Paulo Santos 
Published: September 2023

With the rapid urban growth, the expansion of cities has significantly impacted the environmental dimension. Within cities, open spaces play an important multifunctional role, being areas not occupied by buildings and with social, political and cultural relevance. The Open Space System (OSS) involves elements and relationships that structure this set of open spaces, including its water network, and its understanding is essential for the development and quality of life in urban areas. This bibliographic research used the Systematic Literature Review to understand the state of the art of scientific productions that interrelate public open spaces with water resources. Articles, dissertations and theses were selected. Bibliometric analysis revealed that the topic is widely discussed in specialized journals and has been researched in several countries. This systematic review contributed to outline the relationship between open spaces and water resources, highlighting the importance of integrated urban planning that promotes the conservation of natural resources and the creation of a sustainable urban environment.
Next-generation sequencing-based newborn screening initiatives in Europe: an overview
Authors: Bros-Facer Virginie , Taylor Stacie , Patch Christine 
Published: September 2023

Aim: This article describes results from a survey targeting healthcare professionals (HCPs) leading newborn screening (NBS) initiatives in Europe. The survey was developed within the framework of a dedicated working group set up by the International Rare Diseases Research Consortium (IRDiRC) to gather collective efforts relating to NBS. The objectives of the survey were to gain a better understanding of approaches being tested for the expansion of NBS and to raise awareness of the significant momentum across Europe to evaluate novel technologies for use in future NBS programs.
Methods: A web-based survey including 57 questions was developed to gather information about genomic newborn screening initiatives in Europe that are using next-generation sequencing (NGS) as a first-tier test. Responses were analyzed qualitatively, and aggregated results are presented herein. The identity of some initiatives is not presented to preserve confidentiality.
Results: The findings of the survey indicated that most initiatives are in the planning stage and have not yet started. Although all 14 studies are heterogeneous in design, there is broad consensus that NGS approaches to NBS will, in the short term, be implemented in parallel with current screening programs. The results of this survey can be used to inform the design of studies still in the early planning stages.
Conclusion: Here, we provide an overview of NGS-based initiatives in Europe. Importantly, the initiatives described herein will generate evidence to evaluate the utility and feasibility of NGS approaches to NBS, thereby shortening the pathway to responsible implementation of NGS in NBS and informing future research efforts.
Pengaruh Model Pembelajaran Search, Solve, Create, and Share (SSCS) terhadap Kemampuan Pemahaman Konsep Matematis Peserta Didik SMP Negeri 15 Kota Tangerang Selatan
Authors: Hapsari Nimas Ayu , Salsabila Ellis , Meidianingsih Qorry 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh model pembelajaran Search, Solve, Create, and Share (SSCS) terhadap kemampuan pemahaman konsep matematis peserta didik SMP Negeri 15 Kota Tangerang Selatan. Metode penelitian yang digunakan adalah metode eksperimen semu (quasi experiment). Instrumen penelitian yang digunakan adalah instrumen tes kemampuan pemahaman konsep matematis berupa enam soal uraian yang telah dinyatakan valid dan reliabel. Populasi target penelitian ini adalah peserta didik SMP Negeri 15 Kota Tangerang Selatan. Teknik pengambilan sampel menggunakan Purposive Sampling dan Cluster Random Sampling. Berdasarkan hasil pengujian prasyarat analisis data setelah perlakuan, hasil tes kemampuan pemahaman konsep matematis peserta didik kelas eksperimen dan kelas kontrol berdistribusi normal dan bersifat homogen. Pengujian hipotesis statistik menggunakan Uji-t dengan taraf signifikansi , diperoleh dan . Nilai sehingga ditolak dan diperoleh kesimpulan bahwa rata-rata tes kemampuan pemahaman konsep matematis peserta didik kelas eksperimen lebih tinggi dari kelas kontrol. Besar pengaruh model pembelajaran Search, Solve, Create, and Share (SSCS) terhadap kemampuan pemahaman konsep matematis peserta didik SMP Negeri 15 Kota Tangerang Selatan adalah dengan persentase dan berada pada kategori tinggi. Hal ini menunjukkan bahwa terdapat pengaruh model pembelajaran Search, Solve, Create, and Share (SSCS) terhadap kemampuan pemahaman konsep matematis peserta didik SMP Negeri 15 Kota Tangerang Selatan.

Kata kunci: Pembelajaran matematika, kemampuan pemahaman konsep matematis, model pembelajaran Search, Solve, Create, and Share (SSCS).
Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma according to 107 articles: A systematic review with five analyses
Authors: Sadafi Sepehr , Choubsaz Parsia , Kazemeini Seyed Mohammad Mohyeddin , Imani Mohammad Moslem , Sadeghi Masoud 
Published: September 2023

Abstract

GSTT1 enzyme plays a key role in the neutralization of electrophilic compounds such as carcinogens. Herein, we aimed to evaluate GSTT1 deletion polymorphism and susceptibility to head and neck carcinoma (HNC) according to 107 articles in a systematic review with five analyses. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library until June 21, 2023, with no restrictions to identify pertinent articles. The quality scoring was done using the Newcastle-Ottawa Scale (NOS) tool. The Review Manager 5.3 software was used to calculate the effect sizes, which were displayed as the odds ratio (OR) along with a 95% confidence interval (CI). Both the publication bias and sensitivity analyses were performed using the Comprehensive Meta-Analysis version 3.0 software. To mitigate the risk of false-positive or negative conclusions from meta-analyses, a trial sequential analysis (TSA) was conducted using TSA software.: Of 1966 records retrieved from four databases, 107 full-text articles were included in the analysis. The combined analysis revealed that the pooled OR was 1.28 (95% CI: 1.14 to 1.44; p-value < 0.0001). In terms of ethnicity, the pooled OR was highest in mixed ethnicities. For cancer type, nasopharyngeal cancer had the highest OR. When considering sample size, studies with less than 200 samples had a higher OR compared to those with 200 or more samples. The control source did not significantly affect the OR. The studies with a quality score of 7 or more had a higher OR compared to those with a score less than 7. When both age and sex are considered, while the OR of 1.42 is significant, the high heterogeneity suggests caution in interpreting these results. Finally, in the group where neither age nor sex was considered, no significant association was found. The p-values for both Egger’s test (0.904) and Begg’s test (0.237) are greater than 0.10. TSA reported that the study does not have sufficient statistical power. This comprehensive meta-analysis revealed a significant association between the GSTT1 null genotype and an increased risk of HNC, with variations based on factors such as ethnicity, cancer type, sample size, control source, and quality score.
Utility of screening esophagogastroduodenoscopy performed sequentially with endoscopic ultrasonography
Authors: Kaneko Junichi , Yamada Takanori , Sasada Yuzo , Watahiki Moeka , Kosugi Toshikatsu , Kusama Daisuke , Tamakoshi Hiroki , Niwa Tomoyuki , Takinami Masaki , Tsuji Atsushi , Nishino Masafumi , Takahashi Yurimi , Kawata Kazuhito , Sugimoto Ken 
Published: September 2023

Abstract

Background:Gastric cancer screening using esophagogastroduodenoscopy is crucial in areas in which gastric cancer has a high incidence. To provide more opportunities for gastric cancer screening, we have a protocol of sequential esophagogastroduodenoscopy and endoscopic ultrasonography using each dedicated scope for patients with pancreaticobiliary disease; however, the usefulness of this protocol is not elucidated. This study aimed to investigate the utility of screening esophagogastroduodenoscopy in this protocol for the detection of gastric epithelial neoplasms.Methods:We investigated the utility of screening esophagogastroduodenoscopy performed sequentially with endoscopic ultrasonography for patients with pancreaticobiliary disease at our hospital between April 2020 and September 2022 and compared its detection rate for gastric epithelial neoplasms with that of gastric cancer screening at our medical checkup center. Additionally, a logistic regression model was used to identify factors affecting the detection of gastric epithelial neoplasms.Results:A total of 615 screening esophagogastroduodenoscopies were performed sequentially with endoscopic ultrasonography, and 10 (1.6%) gastric epithelial neoplasms were detected: early gastric cancer in 7 and gastric adenoma in 3. The detection rate of gastric epithelial neoplasms in the protocol was higher than that in the medical checkup center (1.6% vs. 0.2% [14/7,763],p<0.01). Additionally, using a magnification endoscope was the only independent factor affecting the detection of gastric epithelial neoplasms in the protocol (odds ratio, 9.53; 95% confidence interval, 1.98–45.90;p<0.01).Conclusions:A protocol of sequential esophagogastroduodenoscopy and endoscopic ultrasonography is recommended to detect gastric epithelial neoplasms. Additionally, magnification endoscopy may facilitate detection in this protocol.