bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feeling better versus feeling good: interpreting pain relief using minimal clinically important differences and patient acceptable symptom states for patients who underwent lung cancer surgery
Authors: Kang Dan , Zhang Ruoyi , Xu Wei , Dai Wei , Su Xueyao , Huang Yanyan , Zhang Jingyu , Chen Jiaojiao , Xiang Rumei , Shi Qiuling 
Published: November 2023

Abstract

Purpose
Selection of thresholds for pain relief remains empirical and controversial. This study aimed to demonstrate the performance of two mostly used concepts, MCID and PASS, in interpreting perioperative recovery in patients undergoing VATS for lung cancer.
Methods
Patients undergoing VATS were asked to report their pain score daily on a 0–10 scale using PSA-Lung, a validated PRO tool for perioperative symptom measurement. If patients reported a pain score above 3 on the first day post-surgery, pain relief were defined either by MCID (feeling better) or PASS (feeling good) Factors associated with pain relief defined by those two thresholds were analyzed via cox regression models. Median days of pain relief were illustrated using K-M curves.
Results
Among 881 patients with POD1 pain ≥ 4, 805(91.37%) achieved ‘feeling better', and 775 (87.97%)achieved 'feeling good'(P < 0.05). Cox regression analysis showed that CCI scores ([HR]1.234,95%CI 1.022–1.490, P < 0.05) were associated with "feeling better" and single-port thoracoscopic surgery ([HR]1.192,95%CI1.017-1.397, P < 0.05) and no postoperative complications ([HR] 1.316, 95% CI 1.123–1.543) were associated with "feeling good". Using the log-rank test, we identified that patients with better CCI scores needed 4 days (95% CI = 4–5) to "feel better" whereas those with lower CCI scores needed 5 (95%CI = 3–7). Patients undergoing single-port thoracoscopic surgery required 6 days (95% CI = 5–6) to achieve a "feeling good" state compared to 7 days(95%CI = 6–8)for patients undergoing multi-port thoracoscopic surgery (all P < 0.05).
Conclusion
Responders, defined using the MCID and PASS, had similar rates of postoperative pain relief. However, the low agreement between responders and the unique predictors of responders suggests distinct underlying mechanisms and diverse potential applications of these two therapies.
Introducing Mplots: Scaling Time Series Recurrence Plots to Massive Datasets
Authors: Shahcheraghi Maryam , Mercer Ryan , Rodrigues João Manuel de Almeida , Der Audrey , Gamboa Hugo Filipe Silveira , Zimmerman Zachary , Mauck Kerry , Keogh Eamonn 
Published: November 2023

Abstract

Time series similarity matrices (informally, recurrence plots or dot-plots), are useful tools for time series data mining. They can be used to guide data exploration, and various useful features can be derived from them and then fed into downstream analytics. However, time series similarity matrices suffer from very poor scalability, taxing both time and memory requirements. In this work, we introduce novel ideas that allow us to scale the largest time series similarity matrices that can be examined by several orders of magnitude. The first idea is a novel algorithm to compute the matrices in a way that removes dependency on the subsequence length. This algorithm is so fast that it allows us to now address datasets where the memory limitations begin to dominate. Our second novel contribution is a multiscale algorithm that computes an approximation of the matrix appropriate for the limitations of the user’s memory/screen-resolution, then performs a local, just-in-time recomputation of any region that the user wishes to zoom-in on. Given that this largely removes time and space barriers, human visual attention then becomes the bottleneck. We further introduce algorithms that search massive matrices with quadrillions of cells and then prioritize regions for later examination by either humans or algorithms. We will demonstrate the utility of our ideas for data exploration, segmentation, and classification in domains as diverse as astronomy, bioinformatics, entomology, and wildlife monitoring.
A Landscape Governance Approach to Mining Landscape Restoration: Assessing the Evidence in Ghana
Authors: Kaye-Essien Charles Wharton , Yankson Eric 
Published: November 2023

Abstract
Ghana has been struggling to manage the human insecurities of mining resource extraction for several years. Many past approaches have been piecemeal and sector-based interventions, producing limited results. In recent times however, government with support from the World Bank, has shifted attention toward integrated landscape management programs. But to what extent do these programs address the principles and challenges of landscape governance? We answer this question using two landscape restoration programs― the Multi-Sectoral Mining Integrated Project (MMIP) and the Ghana Landscape Restoration and Small-Scale Mining Project (GLRSSMP)―as empirical lenses. Using document analyses as methodology and integrated landscape governance as analytical framework, our findings suggest that the two programs partially meet the desired criteria, and have shortcomings in terms of polycentric governance, multistakeholder engagement and capacity building. The study thus proposes a reconfiguration of the current district mining committees in multi-scalar and multi-actor mining governance regimes. It also articulates knowledge pluralism that is community driven.
Evaluation of two-dimensional total bone uptake (2D-TBU) and bone scan index (BSI) extracted from active bone metastatic burden on the bone scintigraphy in patients with radium-223 treatment
Authors: Fukai Shohei , Daisaki Hiromitsu , Umeda Takuro , Shimada Naoki , Terauchi Takashi , Koizumi Mitsuru 
Published: November 2023

Abstract
Objective: Radium-223 is a first-line alpha-emitting radionuclide treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) with bone metastases, and the completion and prognosis of this treatment are intensively studied. Although the spread-based bone scan index (BSI) and the novel index of intensity-based two-dimensional total bone uptake (2D-TBU) from anomalous hot spot counts of bone scintigraphy may provide useful input in radium-223 treatment, they have not been evaluated in detail yet. This study aimed to fill this gap by evaluating BSI and 2D-TBU in patients treated with radium-223.
Methods: Twenty-seven Japanese patients with mCRPC treated with radium-223 were retrospectively analyzed. The patients were evaluated via blood tests and bone scans at baseline and 3 cycles intervals of treatment. BSI and 2D-TBU were analyzed via VSBONE BSI in terms of correlations, response to radium-223 treatment, and association with treatment completion, and the Kaplan–Meier survival analysis was performed.
Results: Nineteen patients (70.4%) completed six cycles of radium-223 treatment, whereas eight patients (29.6%) did not complete the treatment regimen. A significant difference in baseline BSI and 2D-TBU was observed between these groups of patients. Both BSI and 2D-TBU were highly correlated with treatment response (r = 0.96, p < 0.001). Univariate analysis showed an association between radium-223 completion in median BSI and 2D-TBU values (p = 0.015) and completion percentage differences (91.7% vs. 45.5%; p = 0.027). The Kaplan–Meier product limit estimator showed that the median overall survival was 25.2 months (95% CI: 14.0–33.6 months) in the completion group and 7.5 months (95% CI: 3.3–14.2 months) in the without completion group (p < 0.001).
Conclusions: Both BSI and 2D-TBU showed high correlations and strong agreement with treatment response. In particular, BSI could contain information not only on the spread but also on the comprehensive active intensity of the bone metastatic burden. Furthermore, both indices were associated with treatment completion with superior prognosis in the completion group. This study supports the necessity of preliminary assessment using BSI and 2D-TBU extracted from VSBONE BSI for radium-223 treatment decisions and monitoring.
Parallel 8-directional Array P Systems: An
Application to a Robot Motion Planning Inside a
Rectangular Grid
Authors: Williams Sureshkumar , M Sudhakar , N Narayanan Prasanth 
Published: November 2023

Abstract

A new array P system variant, parallel 8-directional array P systems, is introduced in this paper. In addition, we have found an application for such a system when moving a robot in a rectangular grid from source to destination without colliding with obstacles. The following four cases of robot motion have been discussed. In the grid, we start with a fixed number of static obstacles, followed by a fixed number of dynamic obstacles moving with constant speed, a fixed number of dynamic obstacles moving with varying speeds, and finally, varying numbers of dynamic obstacles moving with constant speed. All these algorithms were solved in polynomial time.
Association between sleep traits and risk of colorectal cancer: A bidirectional Mendelian randomization study
Authors: He Fan , Yang Fuyu , Tang Chenglin , Chen Defei , Xiong Junjie , Zou Yu , Qian Kun 
Published: November 2023

Abstract
Background
Sleep disorders are closely related to disease, especially the impact on cancer has received increasing attention. This study aimed to investigate whether sleep traits have a causal relationship with colorectal cancer (CRC) through a Two-sample Mendelian randomization study (MR).
Methods
In this study, we selected genetic instrumental variables (IVs) for seven sleep traits (sleep duration, get up in the morning, chronotype, nap during day, insomnia, snoring, and daytime dozing) from pooled data of published genome-wide association studies (GWAS). Two-sample MR and multivariate MR analysis study were first conducted to assess the causal association between sleep traits and CRC. The reverse MR analysis was evaluated to the causal relationship between CRC and sleep traits. Inverse variance weighting (IVW), MR Egger, and weighted median were applied to perform the primary MR Analysis.
Results
The multivariate MR analysis found that sleep duration (p = 0.038) and get up in the morning (p = 0.043) were protective effect on CRC, snoring (p = 0.031) were associated with the risk of CRC, get up in the morning (p = 0.003) would reduce the risk of colon cancer, chronotype (p = 0.035) were associated with the risk of colon cancer, and insomnia (p = 0.027) was the protective factor of rectal cancer. There is no evidence found that a causal association between other sleep traits and CRC, colon cancer and rectum cancer through the IVW.
Conclusion
This study indicated that sleep duration and get up in the morning might keep us away from CRC, especially colon cancer, and snoring is the adverse effect on CRC.
Relationship between adolescent Internet addiction and adolescent non-suicidal self-injury: A moderated mediation model
Authors: Liu Nan , Wang Lin , Yin Jiemei , Peng Aiqing 
Published: November 2023

Abstract
Background: Both internet addiction and non-suicidal self-injury are major public health concerns among adolescents, association between internet addiction and non-suicidal self-injury have been observed among adolescents. However, it is unclear how, and under what conditions, internet addiction relates to non-suicidal self-injury. Therefore, this study aimed to construct a moderated mediation model to examine the roles of loneliness and cognitive reappraisal in the relationship between internet addiction and non-suicidal self-injury among Chinese adolescents.
Method: A cross-sectional survey was conducted on 1046 Chinese adolescents. They were asked to complete self-report questionnaires. The questionnaires assessed IA, NSSI, loneliness and cognitive reappraisal.
Results: IA was positively associated with NSSI, and loneliness partially mediated the association between them. In addition, cognitive reappraisal moderated the first half path of the mediation model. Specifically, the higher the level of cognitive reappraisal, the weaker the positive effect of IA on NSSI through loneliness.
Conclusion: Interventions targeted to reduce loneliness and increase cognitive reappraisal strategies may reduce the risk of NSSI in adolescents with Internet addiction.
Evaluation of ALKBH2 gene expression in patients with adult T-cell leukemia
Authors: Wada Yuji , Naito Tadasuke , Ushirogawa Hiroshi , Hatamoto Ayaka , Mizoguchi Yuri , Fukushima Takuya , Saito Mineki 
Published: November 2023

Abstract
Background
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus that causes adult T-cell leukemia (ATL). Patients infected with HTLV-1 are considered HTLV-1 carriers, and a small proportion of patients progress to life-threatening ATL after a long asymptomatic phase. Although countermeasures have been developed to combat HTLV-1 infection and ATL, their pathogenesis remains unclear. Recently, members of the AlkB homolog (ALKBH) family have been shown to participate in oncogenesis in various cancer types, and ALKBH2 is intensively investigated as an interesting candidate in the research field of cancer. To investigate the potential role of ALKBH2 in the pathogenesis of ATL, we analyzed their gene expression dynamics in peripheral blood mononuclear cell-derived clinical specimens obtained from asymptomatic HTLV-1 carriers and patients with acute-type ATL.
Results
The mRNA expression level of ALKBH2 was significantly decreased in asymptomatic HTLV-1 carriers, but reverted in patients with acute-type ATL, correlating with HTLV-1 basic leucine zipper (HBZ) gene expression. Analysis of HBZ transgenic mice suggested inhibited trend of ALKBH2 pre-mRNA expression, and unbalanced mRNA and pre-mRNA expression of ALKBH2 in spleen cells. Then, the pre-mRNA expression of ALKBH2 was investigated in clinical specimens, and it was revealed that they were significantly suppressed in patients infected with HTLV-1, but not in healthy controls. It was also confirmed the unbalanced mRNA and pre-mRNA expression of ALKBH2 was prominent in patients with acute-type ATL.
Conclusions
We discovered dynamically regulated patterns of ALKBH2 gene expression in patients infected with HTLV-1. This study provides novel insights into the roles of ALKBH2 and HBZ in HTLV-1 infection, and contributes to understanding the pathogenesis of ATL.
Changes of White Matter Integrity and Structural Network Topology in Carotid Stenosis Patients with Vascular Cognitive Impairment
Authors: Zhu Huan , Yu Tao , Li Wenjie , Wang Peijiong , Zhang Qihang , Zhu Chenyu , Liu Tong , Zhang Qian , Zhao Jizong , Zhang Yan 
Published: November 2023

Abstract

Background
Patients with carotid artery stenosis (CAS) may have varying degrees of cognitive decline. Some patients have severe cognitive impairment fulfilling the diagnostic criteria for vascular cognitive impairment (VCI), and the underlying mechanisms of this phenomenon remain uncertain. We aim to investigate the reasons in terms of microstructural changes of white matter and alterations in structural network topology in CAS patients with VCI.
Methods
We included 38 unilateral CAS patients, 28 of whom were diagnosed with VCI. Each patient underwent magnetic resonance imaging scans and cognitive assessment. The microstructural integrity of white matter assessed by diffusion tensor imaging and structural network topology was jointly investigated. Correlation analyses were also performed between the structural metrics and general cognitive function.
Results
Decreased fractional anisotropy of white matter fibers including bilateral anterior thalamic radiations, bilateral inferior fronto-occipital fasciculi, forceps major and forceps minor (P < 0.05, Bonferroni corrected) were observed in patients with VCI. Both groups showed small-world topology. The global efficiency and local efficiency of VCI group were decreased, while the small worldness and the characteristic path length increased compared with that of the non-VCI group (P < 0.05). The integrity of forceps minor, left anterior thalamic radiations and bilateral inferior fronto-occipital fasciculi were associated with general cognition (P < 0.05).
Conclusions
Damage to white matter fibers in the frontal lobe and changes in the topological properties of structural networks were the underlying mechanisms of cognitive function deterioration in patients with CAS. The integrity of Fmin, left ATR, and bilateral IFOF may serve as early markers of VCI for CAS patients.
Multiplexed analysis of macrophage polarisation in pulmonary metastases of microsatellite stable colorectal cancer
Authors: Karjula Topias , Elomaa Hanna , Väyrynen Sara A. , Kuopio Teijo , Ahtiainen Maarit , Mustonen Olli , Puro Iiris , Niskakangas Anne , Mecklin Jukka-Pekka , Böhm Jan , Wirta Erkki-Ville , Seppälä Toni T. , Sihvo Eero , Yannopoulos Fredrik , Helminen Olli , Väyrynen Juha 
Published: November 2023

Abstract
Tumour-associated macrophages (TAMs) express a continuum of phenotypes ranging from an anti-tumoural M1-like phenotype to a pro-tumoural M2-like phenotype. During cancer progression, TAMs may shift to a more M2-like polarisation state, but the role of TAMs in CRC metastases is unclear. We conducted a comprehensive spatial and prognostic analysis of TAMs in CRC pulmonary metastases and corresponding primary tumours using multiplexed immunohistochemistry and machine learning-based image analysis. We obtained data from 106 resected pulmonary metastases and 74 corresponding primary tumours. TAMs in the resected pulmonary metastases were located closer to the cancer cells and presented a more M2-like polarised state in comparison to the primary tumours. Higher stromal M2-like macrophage densities in the invasive margin of pulmonary metastases were associated with worse 5-year overall survival (HR 3.19, 95% CI 1.35–7.55, p = 0.008). The results of this study highlight the value of multiplexed analysis of macrophage polarisation in cancer metastases and might have clinical implications in future cancer therapy.
Antibiotic discovery with artificial intelligence for the treatment of Acinetobacter baumannii infections
Authors: Smani Younes , Boulaamane Yassir , Panadero Irene Molina , Hmadcha Abdelkrim , Rey Celia Atalaya , Baammi Soukayna , Allali Achraf El , Maurady Amal 
Published: November 2023

Abstract
The global challenges presented by multidrug-resistant Acinetobacter baumannii infections have stimulated the development of new treatment strategies. We reported that OmpW is a potential therapeutic target in Acinetobacter baumannii. Here, a library of 11,648 natural compounds was subjected to a primary screening using QSAR models generated from a ChEMBL dataset with >7,000 compounds with their reported MIC values against A. baumannii followed by a structure-based virtual screening against OmpW. In silico ADME evaluation was conducted to assess the drug-likeness of these compounds. The ten highest-ranking compounds were found to bind with an energy score ranging from -7.8 to -7.0 kcal/mol where most of them belonged to curcuminoids. To validate these findings, one lead compound exhibiting promising binding stability as well as favourable pharmacokinetics properties, namely demethoxycurcumin was tested against a panel of A. baumannii strains to determine its antibacterial activity using microdilution and time-kill curve assays. To validate whether the compound binds to the selected target, an OmpW-deficient mutant was also studied and compared to the wild-type. Our results demonstrate that demethoxycurcumin in monotherapy and in combination with colistin is active against all A. baumannii strains. Moreover, an increased bacterial growth was observed in the OmpW-deficient mutant suggesting the importance of OmpW for the compound to exhibit its antibacterial activity. Finally, the compound was found to significantly reduce the interaction of A. baumannii with host cells suggesting its anti-virulence properties. Collectively, this study demonstrates artificial intelligence as a promising strategy for the discovery of curcuminoids as antimicrobial agents for combating A. baumannii infections.
Protocol for the Development and Evaluation of Elderly Active &amp; Connected: An Integral Neighbourhood-oriented Approach to Support Healthy Ageing in Low Socioeconomic Older Adults
Authors: Duijsens Lieke J.E. , Lechner Lilian , Peels Denise A. , Bolman Catherine A.W. 
Published: November 2023

Abstract

Background
The rapid ageing of our society poses significant challenges, including an increase in chronic diseases and loneliness among older adults, leading to higher demands for care and support. An integral approach can potentially address the complex support needs of older adults, particularly those in a low socioeconomic position (SEP). For this purpose, we developed Elderly Active & Connected (EAC), a neighbourhood-oriented integral approach focused on supporting healthy ageing in low-SEP older adults. This article outlines EAC’s development process, involving co-creation and a protocol to assess its efficacy.
Methods
The current study employed the Intervention Mapping (IM) protocol, a systematic six-step framework, to develop EAC. The development prioritised co-creation to understand better and align with the needs of low-SEP older adults. This collaboration involved municipalities, local stakeholders, and low-SEP older adults, informing various stages of EAC’s development.
To address the multidimensional nature of healthy ageing, EAC focuses on increasing physical activity, strengthening social connectedness, and improving digital literacy. Building on the proven-effective Active Plus physical activity intervention, EAC extends its scope by incorporating additional holistic and neighbourhood-oriented strategies for support.
EAC’s performance and change objectives were established, integrating existing Active Plus elements and new objectives derived from literature and a needs assessment. Theoretical methods and practical applications were identified, supplemented by strategies informed by co-creation. Intervention materials were adjusted and improved to align with EAC’s methodologies, incorporating linguistic revisions and the involvement of neighbourhood ambassadors.
As a final step, a randomised controlled trial will evaluate EAC’s impact on physical activity, loneliness, social cohesion, health-related quality of life, and digital literacy. This trial will focus on community-dwelling older adults living in both rural and (heavily) urbanised neighbourhoods. This comprehensive evaluation employs various assessments, such as questionnaires and discussions, to provide a nuanced understanding of the intervention’s effectiveness.
Discussion
The EAC intervention, building on Active Plus, shows promise in addressing ageing-related risk factors. Pending a large-scale randomised controlled trial, EAC’s effectiveness may guide future strategies for the integral promotion of public health in vulnerable populations.
Trial registry
This study was prospectively registered at the ISRCTN registry (ISRCTN17170098; November 10, 2022).