bluuebunny/crossref_metadata_2025_split huggingface dataset:
First results of long-term follow-up of children in Russia after gene therapy for hereditary retinal dystrophies associated with biallelic mutations in the RPE65 gene
Authors: Neroev V. V. , Katargina L. A. , Kharlampidi M. P. , Kogoleva L. V. , Zolnikova I. V. , Ilyukhin P. A. , Denisova E. V. , Milash S. V. , Osipova N. A. , Kutsev S. I. , Polyakov A. V. , Zinchenko R. A. , Kadyshev V. V. , Bobrovskaya Yu. A. 
Published: January 2024

Purpose: to evaluate the results of gene therapy by the recombinant adeno-associated viral vector voretigene neparvovec (VN) in children with follow-up periods of 1, 3, 6, and 12 months.Material and methods. The study included 6 children (12 eyes) aged 5 to 15 with a confirmed biallelic mutation in the RPE65 gene, treated with VN (Luxturna, USA). Treatment efficacy was assessed by surveying which included questions on spatial orientation under various types of illumination, Goldman perimetry, microperimetry, best corrected visual acuity (BCVA), electroretinogram (ERG), and visual evoked potentials (VEP). To assess the structure of the retina, the central retinal thickness (CRT) was evaluated by optical coherence tomography.Results. All children showed subjective changes in visual perception, including improved orientation in the dark and twilight, and improved contrast. In one case, the child with initially low visual acuity showed improved visual fixation. In 4 patients out of 6 (8 eyes), an expansion of the visual fields was noted, including 2 cases who displayed significant expansion thereof. In 2 patients (4 eyes), the visual fields were not narrowed and remained so throughout the entire observation period. Mean light sensitivity of the retina in 3 patients and fixation indices in 1 patient improved significantly as shown by microperimetry. BCVA remained stable throughout the study or changed insignificantly. Initially, ERG could not be detected in 8 eyes, but after an VN injection, 6 eyes demonstrated a partial recovery at different times — from 1 to 12 months. An increase in the amplitude of the P1 component to pattern VEP and P2 component to flash VEP was observed in all patients, which indicates an enhanced activity in the projection of the visual cortex after the restoration of the visual cycle. No significant changes were revealed in CRT (p = 0.9). Complications and adverse events were noted in 9 eyes (75 %): chorioretinal dystrophy at the injection site in 3 patients (5 eyes), multifocal nummular dystrophy in 2 patients (4 eyes), local episcleritis in 1 eye, transient increase in intraocular pressure in 2 patients (3 eyes).Conclusion. The results of a one-year post VN treatment follow-up of Russian patients with RPE65-associated inherited retinal disease demonstrate stabilization and improvement of visual functions, which is especially important for otherwise incurable patients with a progressive course of the disease.
A new method of surgical upper eyelid ptosis treatment
Authors: Filatova I. A. , Kondratyeva Yu. P. , Shemetov S. A. , Trefilova M. S. 
Published: January 2024

Purpose: to develop a new method of surgical treatment of moderate upper eyelid ptosis.Material and methods. 88 patients (106 eyes) aged 5–68 years (averagely 24.9 yrs), operated for moderate or severe upper eyelid ptosis, were divided into 3 groups depending on the degree of upper eyelid prolapse and levator function. Group I (43 patients, 47 eyes) had satisfactory mobility of the upper eyelid, its fold being smoothed or absent. Group II (15 patients, 15 eyes) had good mobility of the upper eyelid with a smoothed fold; this group was further divided into subgroups IIa and IIb depending on the technique of the operation. Group III (30 patients, 44 eyes) had low upper lid mobility (less than 4 mm) with no fold. Group I and subgroup IIa underwent a resection of the upper eyelid levator. In subgroup IIb, a new method was used: levatoroplasty with the formation of a levator duplicature. In group III, a suspension operation was performed to the frontalis muscle.Results. In 10 cases (11 %), the results obtained by the new method of ptosis corrections were significantly better as compared to conventional resection: small edemas were resolved within a week, and the mobility of the upper eyelid levator was restored sooner.Conclusion. The proposed technique showed good functional and cosmetic results, proved to be more sparing, retains all upper eyelid tissues and can be successfully used for moderate upper eyelid ptosis.
A scoping review of human pathogens detected in untreated human wastewater and sludge
Authors: Corrin Tricia , Rabeenthira Prakathesh , Young Kaitlin M. , Mathiyalagan Gajuna , Baumeister Austyn , Pussegoda Kusala , Waddell Lisa A. 
Published: January 2024

Abstract

Wastewater monitoring is an approach to identify the presence or abundance of pathogens within a population. The objective of this scoping review (ScR) was to identify and characterize research on human pathogens and antimicrobial resistance detected in untreated human wastewater and sludge. A search was conducted up to March 2023 and standard ScR methodology was followed. This ScR included 1,722 articles, of which 56.5% were published after the emergence of COVID-19. Viruses and bacteria were commonly investigated, while research on protozoa, helminths, and fungi was infrequent. Articles prior to 2019 were dominated by research on pathogens transmitted through fecal–oral or waterborne pathways, whereas more recent articles have explored the detection of pathogens transmitted through other pathways such as respiratory and vector-borne. There was variation in sampling, samples, and sample processing across studies. The current evidence suggests that wastewater monitoring could be applied to a range of pathogens as a public health tool to detect an emerging pathogen and understand the burden and spread of disease to inform decision-making. Further development and refinement of the methods to identify and interpret wastewater signals for different prioritized pathogens are needed to develop standards on when, why, and how to monitor effectively.
Predictive Factor of Tumor Aggressiveness in Patients with Extrahepatic
Cholangiocarcinoma Based on Diffusion-weighted MRI
Authors: Huang Xinqiao , Shu Jian , Wang Jianmei 
Published: January 2024

Background::
Extrahepatic cholangiocarcinoma (EHCC), an exceedingly malignant neoplasm, often eludes early detection, culminating in a dire prognosis.
Accurate cancer staging systems and pathological differentiation are designed to guide adjuvant interventions and predict postoperative prognoses

Objective::
This study sought to investigate the predictive capacity of DW-MRI in discerning T stages, lymph node metastasis, and pathological differentiation
grades in patients with EHCC.

Methods::
Eighty-five patients were pathologically diagnosed with EHCC who underwent abdominal MRI within two weeks before surgery at our hospital
from Aug 2011 to Aug 2021. Tumor axial maximum area (AMA) and apparent diffusion coefficient (ADC) values for diverse T stages, N stages,
and differentiation grades were retrospectively analyzed.

Results::
The Mann-Whitney U test displayed significantly higher lesion AMA values (P =0.006) and lower tumor ADC values (P = 0.001) in the nodepositive
group (median ADC and AMA value: 1.220×10-3 mm2/s, 82.231 mm2) than in the node-negative group (median ADC and AMA value:
1.316×10-3 mm2/s, 51.174 mm2). A tumor ADC value<1.249×10-3 mm2/s from the receiver operating characteristic curve (AUC=0.725, P=0.001)
exhibited the capability to predict node-positive EHCC with a sensitivity of 64.29%, and specificity of 73.68%. Furthermore, a progressive
decrease in the degree of EHCC differentiation was associated with a reduction in the tumor ADC value (P=0.000).

Conclusion::
The N stage and differentiation of EHCC can be evaluated non-invasively using diffusion-weighted MRI.
De Hohenzollern in de beklaagdenbank. De verloren zaak van de Pruisische dynastie na 1918
Authors: Lantink Frans Willem 
Published: January 2024

Review of: Stephan Malinowski, Die Hohenzollern und die Nazis. Geschichte einer Kollaboration (Berlin: Propyläen/Ullstein, 2021, 752 pp, ill., reg.); Stephan Malinowski, De adel en de nazi’s. De collaboratie van de Duitse keizerlijke familie, vert. Gerrit Bussink en Izaak Hilhorst, met een voorwoord door Beatrice de Graaf (Amsterdam: Nieuw Amsterdam, 2022, 624 pp., ill. reg.).
Home-Sharing in South Australia: Protecting the Rights of Hosts, Guests, and Neighbours
Authors: Lazar Alex 
Published: January 2024

Internet facilitated home-sharing services like Airbnb present new challenges for South Australian law because they appear to create seemingly novel legal relationships. This article considers whether South Australian law adequately protects the rights of hosts, guests and neighbours who are affected by home-sharing agreements. It argues, first, that home-sharing is currently a legal activity and land use in most of South Australia; secondly, that the relationships between host and guest are capable of being recognised under residential tenancy and property law; and thirdly, that while current legislation protects home-sharing neighbours living in strata housing, the law of private nuisance is not capable of protecting the rest. This article concludes that the rights of the host and guest are capable of being recognised and regulated by existing domestic law; however, it suggests that local councils should set up home-sharing complaints systems to protect neighbours.
THE NEED FOR AUSTRALIAN CRIMINAL LAW REFORM TO PROTECT ELDERLY AUSTRALIANS AGAINST ABUSE
Authors: Hutchens Vanessa 
Published: January 2024

The Australian Bureau of Statistics have reported that Australia’s population is ageing at
an incremental rate, and a recent National Prevalence Study into elder abuse found that a
significant proportion of those older Australians are experiencing abuse. While it is
important to recognise that older people are not inherently vulnerable, it is equally
important to acknowledge the fact that many instances of abuse are falling through the
cracks. Older people with distinct vulnerabilities, are at particular risk, and it is the right
of every older Australian to age with dignity, respect, and to be afforded adequate protection
from abuse. Despite the existence of criminal laws applicable to abuses including physical,
social, psychological, and financial, very few matters relating to abuse of older people are
prosecuted.
This paper provides an overview of the legal framework in which abuse of older adults
currently operates in Australia. It proposes that discrete criminal offences should be
introduced to protect older adults who are reliant on others for their care, and who have a
distinct vulnerability.
A Toolkit for Evaluating the Effectiveness of Parliamentary Public Engagement
Authors: Moulds Sarah 
Published: January 2024

There is a growing acceptance among Australian parliaments that enhancing the quality and diversity of engagement between the public and Australian parliaments is essential to preserving trust in democratic institutions and managing community expectations of transparency and accountability for parliamentary lawmaking and government decision-making. In the wake of the COVID-19 pandemic, digital engagement techniques became increasingly attractive to parliaments with the potential to improve both the quality and efficiency of public engagement in lawmaking, savings, and possible improvements in democratic participation. To capitalise on these potential benefits, and to avoid any unjustifiable risks, parliaments must understand the importance of connecting the people to their parliaments and which practices and technologies could be used to improve the quality and diversity of public engagement with parliaments in Australia. Drawing upon insights shared during a series of international workshops on public engagement by the International Parliamentary Engagement Network (‘IPEN’), this article aims to describe the key ingredients for effective evaluation of public engagement by parliaments and share the toolkit developed by the IPEN workshops.
Effect of Variation in Pineapple Leaf Fiber Composition with Polyurethane Matrix in Composite Panels on Acoustic Properties and Porosity
Authors: Adil Putra , Darvina Yenni , Ramli - , Anshari Rio 
Published: January 2024

Noise can cause medical, psychological, and environmental disturbances. One of the efforts to reduce noise is by using acoustic materials. Acoustic materials can be made using natural fiber composites. This study uses pineapple leaf fiber as fiber and polyurethane as a matrix that will be formed into a sound-absorbing composite panel. This study aims are to determine the effect of variations in the composition of pineapple fiber-reinforced composites with polyurethane matrix on acoustic properties and porosity, determine the effect of frequency on acoustic properties, and determine the relationship between porosity and acoustic properties. The method used in this research uses a characterization tool in the form of a one-microphone impedance tube and porosity test equipment. Composite panels are made by varying the composition of pineapple leaf fibers with polyurethane matrix with the ratio of pineapple leaf fiber composition to polyurethane matrix, namely 50%: 50%, 60%: 40%, 70%: 30%, 80%: 20% and 90%: 10%. Based on the research, it was found that the more the amount of pineapple leaf fiber composition is used, the absorption coefficient, sound transmission loss, and prostitution will increase while the reflection coefficient decreases. The higher the frequency used, the absorption coefficient and sound transmission loss will increase while the reflection coefficient decreases for all frequencies. The relationship between porosity and acoustic properties is that the higher the porosity, the absorption coefficient and sound transmission loss will increase while the reflection coefficient decreases
Efektivitas Media Puzzle Terhadap Penguasaan Hiragana Siswa SMA
Authors: Zhelita Bunga Putri , Arni Rita 
Published: January 2024

Mempelajari hiragana bukanlah suatu hal yang mudah, karena dari segi huruf, hiragana mempunyai bentuk huruf yang berbeda-beda dan jumlahnya banyak, sehingga hal itulah yang membuat pembelajar bahasa Jepang merasa kesulitan. membantu mereka merasakan misalnya kesulitan dalam membedakan atau mengingat huruf. Berdasarkan observasi peneliti pada saat melakukan Praktek Kerja Lapangan (PLK) periode Juli-Desember 2022 di SMAN 13 Padang dan wawancara yang dilakukan kepada guru dan siswa di sekolah tersebut, diketahui bahwa siswa mengalami kesulitan dalam mempelajari hiragana karena mempunyai ruang yang besar. banyaknya huruf dan kesamaan bentuk huruf sehingga menyebabkan menurunnya penguasaan dan minat belajar hiragana. Oleh karena itu, untuk mengatasi permasalahan tersebut diperlukan suatu media pembelajaran yang lebih menarik dan efektif untuk membantu atau memudahkan siswa dalam meningkatkan penguasaannya ketika mempelajari hiragana. Penggunaan media puzzle dapat membantu atau mengatasi permasalahan tersebut. Penelitian ini bertujuan untuk mengetahui pengaruh media puzzle terhadap penguasaan hiragana siswa kelas XII IPS SMAN 13 Padang. Metode penelitian yang digunakan adalah eksperimen kuantitatif dengan desain one-group pretest-posttest. Data diperoleh dengan menggunakan teknik purposive sampling yaitu kelas XII IPS 3 yang berjumlah 32 orang. Hasil uji-t diterima pada taraf signifikansi 0,05, karena nilai sig < 0,05 (0,000 < 0,05) yang berarti penguasaan hiragana pada posttest jauh berbeda dengan pretest. Dengan kata lain penggunaan media puzzle yang efektif dalam pembelajaran hiragana.
ANALISIS KEMAMPUAN PENGGUNAAN JOUKEN HYOUGEN MAHASISWA PRODI PENDIDIKAN BAHASA JEPANG ANGKATAN 2020 UNIVERSITAS NEGERI PADANG
Authors: Sania Sania , Putri Meira Anggia 
Published: January 2024

The study is in the background of Jouken Hyougen, which has the same meaning, so students have difficulty distinguishing the use of a form of reinforcement in a sentence. This study aims to describe the ability to use jouken hyougen (to, ba, tara, and nara) by Japanese language students in the class of 2020 at the Japanese Language Education study program at Padang State University. The kind of research used in this study is a descriptive method whose data is in the form of scores. The population in this study is the 2020s Japanese language students of the 2020 class of Padang State University of 51. The sample in this study uses the full sampling population, in which the entire population is sampled by 2020 Japanese education students of Padang State University, conducted by 35 people. The data in this study is the value of the results of the test capability to use jouken hyougen at a 2020 Japanese language education Padang State University. Based on the results of the study conducted, the overall ability of the 2020 Japanese language education department at Padang State University is 'less' qualified, with an average value of 47.43. Keywords: Ability, Jouken Hyogen, Japanese language
Menumbuhkan Kreatifitas Digital di Kampung Caping Pontianak
Authors: Hanum Atiqa Nur Latifa , Sahidi Sahidi , Madeten Sisily Saman , Amir Amriani , Rahman Mifta 
Published: January 2024

Keberadaan Kampung Caping mulai ramai diperbincangkan karena keunikan dan pengembangan lingkungan kampung sebagai destinasi wisata berbasis kearifan lokal. Kampung Caping menyuguhkan beberapa edukasi menarik bagi para wisatawan yang berkenan mengunjungi. Perpustakaan Bahagia Mendawai merupakan salah satu unit yang berada di kawasan Kampung Caping yang berperan mengedukasi warga sekitar. Guna mendukung kemajuan kawasan tersebut, tim pengabdian bermitra dengan perpustakaan Bahagia Mendawai agar para pengelola perpustakaan maupun warga mendapat keterampilan untuk meningkatkan kemampuan literasi, menjadikan warga lebih mandiri dan maju. Tim pengabdian masyarakat Prodi D-3 Perpustakaan berupaya berkontribusi memberikan keterampilan melalui program pelatihan keterampilan kreativitas digital di Kampung Caping. Dalam pelaksanaannya, tim berkolaborasi dengan mahasiswa dan mitra. Metode yang dipilih berupa workshop dalam bentuk tutorial dan project-based, dilanjutkan dengan diskusi mengenai pembuatan infografis dan e-book sebagai media publikasi produk dan kegiatan Kampung Caping. Masyarakat sasarannya terdiri dari pengelola perpustakaan Bahagia Mendawai, ibu rumah tangga, dan siswa sekolah di sekitar Kampung Caping dengan total peserta 31 orang. Hasilnya para pengelola Perpustakaan Bahagia Mendawai memperoleh pengetahuan pembuatan infografis dan memanfaatkannya untuk mendokumentasikan kegiatan perpustakaan, mendampingi warga untuk publikasi karya, dan meningkatkan minat berkarya sehingga kemampuan literasi meningkat. Ibu-ibu mendapat keterampilan memanfaatkan platform book creator untuk mendokumentasikan karya anak mereka menjadi buku digital. Siswa sekolah juga bisa memanfaatkan kedua platform tersebut untuk membantu mempermudah merangkum poin-poin inti pelajaran menggunakan infografis dan berkarya menulis cerita sederhana secara digital menggunakan book creator. Kata kunci: Literasi Digital, Infografis; Buku Digital
Family Resilience Councelling Model in Reducing The Divorce at Religious Courts Class I-A Pontianak
Authors: Nurrahmi Hesty , Fauziah Fauziah , Kinanti Kinanti 
Published: January 2024

This research is motivated by the high divorce rate and the implementation of the mediation process in Religious Court Class I-A Pontianak in 2020-2021. The objectives of this research are to find out the factors causing the high divorce rate and how the mediation process is implemented. This research applied qualitative research methods. The research techniques used were documentation and interviews. This research reveals that: 1. The factors causing the high divorce rate in the Religious Court Class I-A Pontianak in 2020-2021 are: disputes and quarrels; economic problems; leaving their spouses; gambling; and domestic violence (KDRT), and 2. The mediation process carried out by the mediator is based on the Regulation of the Supreme Court of the Republic of Indonesia Number 1 Year of 2016, namely (a) submit a resume of the case to the mediator, the mediation process is not more than 30 days from the determination; (b) the material will be completed based on the problems experienced; (c) the mediator can invite the experts or community figures who can help resolve the problem with an agreement between the two parties and the mediator, and (d) if the mediation process is successful, the mediator is obliged to issue a peace treaty or agreement. This research provides recommendations: (a) academically, the opportunity to become a non-judge mediator can be fulfilled by alumni of the Islamic Guidance and Counselling Study Program who have taken mediator training; and (b) the mediator's ability and skills in the mediation process and the intense desire of the married couple to unite can reduce the rate of divorce.
Localisation of the Unerupted Maxillary Canine Additional Observations
Authors: Jacobs Stanley G. 
Published: January 2024

Abstract
Occlusal radiographs are recommended for the tube shift method used to localise the unerupted maxillary canine. Several case histories are presented to explore how diagnostic occlusal films may be obtained. The initial maxillary incisor inclination determines the vertical angulation of the tube, while the mesio-distal position of the canine crown determines the horizontal angulation of the tube to the mid-sagittal piane. Increased distances aid localisation: both the distance between the impacted tooth and its reference tooth, and the distance between the positions of the tube at exposure are significant. If an orthopantomogram and an occlnsal film are to be taken as initial radiographs, the orthopantomogram should be read first to determine the position of the tube for the occlusal film. Radiographs taken prcviously niay provide iuformation on centring the tube for the occlusal film. The horizontal tube shift between Lwo occlnsal fihns is a more sensitive means of localising canines than is the vertical tnbe shift available bctween an orthopantonmogram and an occlusal film.
Tooth Movement Following Third Molar Removal
Authors: Thurnwald G.A. , Monsour F.N. , L’Estrange P.R. 
Published: January 2024

Abstract
The mandibular dental arches of 45 young adults (mean age = 24.3 years) were analyzed by measuring study casts taken immediately before and twelve weeks after the removal of impacted third molar teeth. Arch length and width were measured at predetermined points on the study casts. The results showed significant buccal movement of mandibular second molar teeth following surgery (p < 0.01). Bilateral mesioangular impactions were associated with larger increases in mandibular arch width following surgery than unilateral mesioangular hnpactions or other classes of impaction (p < 0.05). The greatest amount of tooth movement was observed in cases where mandibular second molars had a pre-operative lingual inclination. It is hypothesised that mesioangularly impacted mandibular tlrird molars can produce sufficient force to displace the adjacent second molar teeth in a lingual direction and when the adjacent tlrird molar is removed this movement is reversed by functional forces.