bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of bilateral adrenal myelolipoma in congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: A rare and uncommon finding
Authors: Kumar Ega Lakshman , Kudugunti Neelaveni , Sudhakaran Lekshmi , Sahay Rakesh Kumar 
Published: December 2023

Abstract
Congenital adrenal hyperplasia (CAH) is a common endocrine disorder that can lead to poor quality of life and the development of adrenal and extra-adrenal mass lesions when poorly controlled. Adrenal myelolipomas are rare, benign neoplasms that have been observed in long-standing, uncontrolled CAH cases. In this report, we describe a 31-year-old patient with ambiguous genitalia, hypokalemia, and normotension. The hormonal profile showed elevated 11-deoxy cortisol and 17-hydroxy progesterone. The clinical and biochemical profile was suggestive of CAH due to 11-beta-hydroxylase deficiency. On evaluation for pain abdomen, bilateral large adrenal myelolipomas were found for which surgery was done. Presently the index case is on steroid replacement therapy. This case emphasizes the importance of timely diagnosis adherence to treatment and appropriate follow-up of CAH cases in order to prevent the development of adrenal myelolipomas.
MODY-5: A diagnosis more often missed than made
Authors: Prasad Trupti Nagendra , Bhadada Sanjay Kumar , Dutta Pinaki , Mukherjee Soham , Pal Rimesh , Konsam Biona Devi , Tiwari Vivek Premshankar , Baruah Mintu Mani 
Published: December 2023

Abstract
Maturity-onset diabetes of the young (MODY) is the most common cause of monogenic diabetes, having 14 subtypes. Amongst MODY, MODY-5 accounts for less than 5% of cases. Along with diabetes, it presents with a number of extra-pancreatic manifestations. We report a case of a 15-year-old boy with diabetes, renal dysfunction, and obstructive uropathy. This presentation along with lean phenotype, absence of ketosis, and features of insulin resistance with a relatively preserved beta cell function suggested a diagnosis of MODY. This was later confirmed by genetic analysis. The patient progressed to develop chronic kidney disease and was managed with insulin therapy with interventions for obstructive uropathy.
An Exploratory Study of Cervical Vestibular-Evoked Myogenic Potential in Users of Personal Listening Devices
Authors: Dessai Teja Deepak , Bhat Rashmi J. , Kumar Kaushlendra 
Published: December 2023

Context:
The use of personal listening devices (PLDs) is becoming increasingly popular, particularly among young people. Numerous studies have demonstrated that being exposed to PLDs can have adverse effects on the auditory system. Owing to the similarities between the auditory and vestibular systems, it is possible that the negative effects of PLD use may extend to the vestibular system, an area that has not been extensively studied.

Aim:
The study aimed to investigate the impact of exposure to PLDs on the vestibular system, specifically the sacculo-collic reflex assessed by the cervical vestibular-evoked myogenic potential.

Settings and Design:
The current study used a cross-sectional study design.

Materials and Methods:
A total of 80 participants were divided into four groups based on the history of PLD exposure. Each group consisted of 20 participants who underwent cervical vestibular-evoked myogenic potential (cVEMP) testing using alternating polarity 500 Hz tone bursts.

Statistical Analysis Used:
Analysis of variance (ANOVA) and Bonferroni post hoc test were used to obtain the statistically significant difference among the group.

Results:
The results showed that the amplitude of p1-n1 of cVEMP was significantly reduced in individuals with longer PLD exposure duration.

Conclusion:
The study suggests that listening to music through a PLD at high levels of volume controls could be deleterious to the vestibular well-being of an individual. The study highlights the importance of being aware of the adverse effects of using PLDs to prevent potential damage to the vestibular systems.
The Role of Noise Annoyance and Noise Sensitivity in the Effect of Aircraft Noise on Self-Reported Health
Authors: Kodji Minon′tsikpo Kossi , Lanoy Émilie , Giorgis-Allemand Lise , Laumon Bernard , Evrard Anne-Sophie 
Published: December 2023

Background:
Transportation noise seems to impair self-reported health status (SRHS). However, only a few studies have considered the role of noise annoyance and noise sensitivity in this deleterious effect. This study aims investigating mediator and moderator roles of noise annoyance and noise sensitivity.

Methods:
In 2013, the DEBATS longitudinal study included 1244 participants aged over 18 years and living around three French airports. These participants were followed up in 2015 and 2017. They self-reported their perceived health status, aircraft noise annoyance, and their noise sensitivity via a questionnaire during the three visits. Noise maps were used to estimate aircraft noise levels at the facade of participants’ residence. Generalized linear mixed models with a random intercept at the participant level were used.

Results:
Aircraft noise levels were associated with severe annoyance. Severe annoyance tent to be associated with impaired SRHS. Aircraft noise levels were associated with impaired SRHS only in men (odds ratio [OR] = 1.47, 95% confidence interval [CI] = [1.02, 2.11], for a 10-dBA L
den increase in aircraft noise levels) with a weaker association adjusted for annoyance (OR = 1.36, 95% CI = [0.94, 1.98]). The association was stronger in men who reported high noise sensitivity (OR = 1.84, 95% CI = [0.92, 3.70], versus OR = 1.39, 95% CI = [0.90, 2.14], for men who were not highly sensitive to noise).

Conclusion:
From our results, the deleterious effect of aircraft noise on SRHS could be mediated by noise annoyance and moderated by noise sensitivity. Further studies using causal inference methods are needed for identifying causal effect of exposure, mediator, and moderator.
The Effect of Noise Exposure on Hearing Function and Vestibular Evoked Myogenic Potentials
Authors: Cetinbag-Kuzu Ozgenur , Bahadir Hande , Guneri Enis Alpin , Cimrin Arif Hikmet , Kirkim Gunay 
Published: December 2023

Purpose:
Exposure to noise can cause damage to both auditory and vestibular systems. The objective of this study is to evaluate how noise exposure affects the hearing and vestibular systems in individuals with noise-induced hearing loss (NIHL).

Methods:
This study included 80 subjects (40 subjects with NIHL, and 40 controls), between 26 and 59 years old. For hearing assessment, pure-tone audiometry, extended high-frequency audiometry, tympanometry, acoustic reflex threshold, and distortion product otoacoustic emission tests were used; for vestibular assessment, the cervical and ocular vestibular evoked myogenic potentials tests were used.

Results:
Statistically significant differences were found between the two groups in 3 to 6 kHz frequency thresholds; in extended high-frequency audiometry tests, there were also significant differences between groups at all frequencies from 9.5 to 16 kHz. The cervical and ocular vestibular evoked myogenic potentials thresholds were significantly higher and N1-P1 amplitudes were significantly lower in the NIHL group.

Conclusion:
Noise can lead to damage to both auditory and vestibular functions. Therefore, audiological assessments and vestibular evoked myogenic potentials could be clinically useful for examining patients with NIHL.
Automated ophthalmic imaging analysis in the era of Generative Pre-Trained Transformer-4
Authors: Waisberg Ethan , Ong Joshua , Masalkhi Mouayad , Kamran Sharif Amit , Zaman Nasif , Sarker Prithul , Lee Andrew G. , Tavakkoli Alireza 
Published: December 2023

Abstract
AI is just beginning to be integrated into clinical medicine, and will continue to be integrated into clinical care. ChatGPT has already been used in ophthalmology to triage symptoms, write operative notes, answer ophthalmic board-exam level questions and for medical education. GPT-4 builds upon the abilities of the prior GPT models by delivering more sophisticated natural language processing capacities, making it an AI technology with high potential application for medical imaging analysis. We wanted to examine GPT-4’s ability to interpret ophthalmic images. Although GPT-4 remains a promising start to the future of ophthalmic imaging analysis, further research and modifications will be necessary before the technology can be used for high stakes clinical encounters in human patients.
Good practices in simulation-based education in ophthalmology – A thematic series. An initiative of the Simulation Subcommittee of the Ophthalmology Foundation Part IV: Recommendations for incorporating simulation-based education in ophthalmology training programs
Authors: Filipe Helena Prior , Luciano Andreas Di , Clements John , Grau Arturo , Thomsen Ann Sofia Skou , Lansingh Van , Musa Pablo , Ng Danny Siu-Chun , Labuschagne Mathys 
Published: December 2023

Abstract
Recommendations could be useful to guide institutions planning to incorporate simulation-based education (SBE) into their training programs or institutions that have an established program but want to benchmark it against best practices. An effective, inclusive, and enjoyable simulation learning environment must be created to optimize learning and skills development. Areas to consider when proposing recommendations for creating an effective SBE environment include the following: the environment, group learning, facilitators, and educational requirements. The common pitfalls in simulation design when simulations are not effective include inadequate prebriefing, cognitive overload, poor alignment with the real-world context or task, inadequate debriefing, and insufficient time for debriefing. The ethical imperatives of SBE must inform the training programs. The role players in the shared ethical values when using SBE include the patients, students, simulationists, and the simulators and simulated patients. SBE programs must be embedded into a curriculum and should not be an optional add-on. To ensure high standards of training in simulation centers, these centers must adhere to specific accreditation standards. SBE aims to create a better training environment, improve patient safety, and address the challenges regarding the training platform and the burden of disease in eye care globally. Surgical simulation in ophthalmology provides an opportunity for partnership between institutions nationally and across borders because simulation centers cannot function in isolation. Recommendations for creating collaborations and partnerships for surgical simulation training will enhance the impact of any eye care program.
The Perioperative Profile of Community Outreach Camp Patients with Pseudoexfoliation Who Underwent Cataract Surgery in a Tertiary Care Centre
Authors: Kumarasamy Murugan , Palani Subashree , Subramaniam Gnaneswaran 
Published: December 2023

Purpose:To study the perioperative profile of pseudoexfoliation (PXF) among the camp patients who underwent cataract surgery.Methods:This retrospective study was conducted among camp patients with PXF, who underwent cataract surgery in a tertiary care centre. Anterior segment examination including distribution of PXF material over anterior segment structures, pupillary dilatation, gonioscopy, applanation tonometry, intraoperative and postoperative complications, and subsequent management were all documented from the records.Results:A total of 1985 patients underwent cataract surgery between November 2016 and October 2019 of which PXF was recorded in 140 (7%) patients. 49 patients had bilateral PXF, while 83 patients had unilateral PXF. 50% (91/181) of eyes had PXF on anterior lens capsule and pupillary border and 67% (113/167) of eyes had both cortical and nuclear cataracts simultaneously. Intraocular pressure (IOP) was significantly elevated in PXF eye of unilateral PXF patients. The prevalence of PXF glaucoma in our study population was 2.8%. 16.7% (22/132) of patients had intraoperative complications of which posterior capsule rent (PCR) occurred more in bilateral PXF patients and zonular dehiscence (ZD) was seen more in unilateral PXF patients. Postoperatively, surge in anterior segment inflammation was noted from 8% on the first day to 11% at the end of the first week.Conclusions:PXF eyes require meticulous preoperative examinations and intraoperative handling to prevent complications like ZD and PCR. Following cataract surgery, these patients require frequent follow-up visits in the initial two weeks of postoperative period to address the surge in anterior chamber reactions.
Clinical Outreach Training and Supportive Supervision Quality-of-Care Analysis: Impact of Readiness Factors on Health Worker Competencies in Malaria Case Management in Cameroon, Mali, and Niger
Authors: Bernard Yves-Marie , Ahmed Jehan , Mostel Jadmin , Ba Thierno , Ciceron Annie Coriolan , Busiga Moses , Koné Aissata , Kamaté Beh , Sidibé Fatoumata , Diallo Chebou , Makayi Alzouma , Koko Daniel Christian , Djibrilla Arouna , Ateba Joël , Tchinda Meli Eric , Tchadjeu Christophe , Griffith Kevin , Burns Jordan , Barat Lawrence M. 
Published: December 2023

ABSTRACT.
Improving the quality of malaria clinical case management in health facilities is key to improving health outcomes in patients. The U.S. President’s Malaria Initiative Impact Malaria Project has supported implementation of the Outreach Training and Supportive Supervision (OTSS) approach in 11 African countries to improve the quality of malaria care in health facilities through the collection and analysis of observation-based data on health facility readiness and health provider competency in malaria case management. We conducted a secondary analysis of longitudinal data collected during routine supervision in Cameroon (April 2021–March 2022), Mali (October 2020–December 2021), and Niger (November 2020–September 2021) using digitized checklists to assess how service readiness affects health worker competencies in managing patients with fever correctly and providing those with confirmed uncomplicated malaria cases with appropriate treatment and referral. Linear or logistic regression analyses were conducted to assess the effect of facility readiness and its components on observed health worker competencies. All countries demonstrated significant associations between health facility readiness and malaria case management competencies. Data from three rounds of OTSS visits in Cameroon, Mali, and Niger showed a statistically significant positive association between greater facility readiness scores (including the availability of commodities, materials, and trained staff) and health worker competency in case management. These findings provide evidence that health worker performance is likely affected by the tools and training available to them. These results reinforce the need for necessary tools and properly trained staff if high-quality malaria case management services are to be delivered at health facilities.
The art of Dagdangijn Amgalan: features of stylistic development and artistic content
Authors: Уранчимэг Д. , Яйленко Е.В. 
Published: December 2023

В статье рассматривается творчество выдающегося монгольского художника XXвека Дагдангийна Амгалана. До сих пор оно еще мало изучено и к тому же недостаточно известно в России, хотя роль Амгалана в развитии изобразительного искусства Монголии представляется исключительно важной. Основная задача данной статьи состоит в создании научно-методологической основы для систематизации обширного фактического и историко-художественного материала, впервые в таком объеме публикуемого в отечественной научной периодике. Впервые прослеживается творческая эволюция монгольского художника, обозначаются и характеризуются ее отдельные этапы, раскрывается стилистическое и идейно-содержательное своеобразие каждого из них. Отдельно рассматриваются вопросы о том, какую роль сыграло творчество Амгалана в распространении в монгольском искусстве «сурового стиля» и как изменились на местной почве его заимствованные формальные и тематические принципы. Также показано, что Амгалан стоял у истоков возрождения национальной традиции в художественной школе Монгольской Народной Республики, причем в качестве основного достижения в данной области рассматривается оформление Дворца бракосочетания в Улан-Баторе, выполненное по его проектам. Однако, в то же самое время, будучи необычайно разносторонним художником, во второй половине 1970-х годов Амгалан выполнил ряд картин, в которых получили отражение идеи модернизма.
This article investigates artistic legacy of Dagdangijn Amgalan, an outstanding Mongolian artist of the 20th century. Although he played a significant part in the development of Mongolian art, his oeuvre hasn’t been studied yet in a satisfactory way and hasn’t still been well-known for Russian readers. The main goal of this article consists in providing the solid scientific base for the systematization of a great number of facts and artworks connected to Amgalan. This new material has never been introduced to the scientific research in the Russian Federation. The article provides an overview of the whole development of Amgalan as a painter and designates individual stages in this process as well as their peculiar features in what concerns style and subject-matter. It also examines how Amgalan contributed to the dissemination of the principles of the “austere style” in Mongolian art as well as further development of its stylistic principles and content. It has also been demonstrated that Amgalan was an initiator of the revival of the vernacular artistic tradition in the art of the Mongolian People’s Republic. His main achievement in this sphere constitutes the inner decoration of the Matrimonial Palace in Ulaanbaatar. Nevertheless, at the same time, in the late 1970s Amgalan produced some paintings related to the concept of Modernism.
So sánh kết quả chuyển phôi nang nguyên bội giữa nhóm bệnh nhân có tuổi mẹ thấp và tuổi mẹ cao tại hệ thống IVF Mỹ Đức
Authors: Trương Văn Hải , Nguyễn Thị Thủy Tiên , Nguyễn Quỳnh Như , Đỗ Thị Linh , Nguyễn Cao Trí 
Published: December 2023

Mục tiêu: So sánh kết quả chuyển đơn phôi nang nguyên bội giữa nhóm bệnh nhân có tuổi mẹ thấp (< 35 tuổi) và tuổi mẹ cao (≥ 35 tuổi) tại hệ thống IVF Mỹ Đức.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu thực hiện trên 208 bệnh nhân thỏa mãn điều kiện: có chỉ định thực hiện PGT-A, chuyển đơn phôi nang nguyên bội, và nội mạc tử cung > 7 mm vào ngày chuyển phôi, chia làm 2 nhóm: (i) nhóm tuổi mẹ < 35 tuổi (N =128) và nhóm tuổi mẹ ≥ 35 tuổi (N = 80). Nghiên cứu đánh giá tỷ lệ thụ tinh, phát triển phôi và kết quả chuyển phôi nang nguyên bội giữa 2 nhóm tuổi.
Kết quả: Số lượng noãn thu nhận sau chọc hút, số hợp tử thụ tinh, hiệu quả phát triển phôi nang và số lượng phôi nang tốt ở nhóm bệnh nhân < 35 tuổi cao hơn so với nhóm ≥ 35 tuổi. Kết quả lâm sàng sau khi chuyển phôi giữa 2 nhóm bệnh nhân có tuổi mẹ < 35 tuổi và ≥ 35 tuổi không có sự khác biệt mang ý nghĩa thống kê. So sánh lần lượt ở nhóm tuổi mẹ < 35 và nhóm ≥ 35: tỷ lệ beta hCG dương là 77,6% so với 78,4% (p = 0,95); tỷ lệ thai lâm sàng 67,8% so với 72,7% (p = 0,509); tỷ lệ trẻ sinh sống 42,8% so với 43,2% (p = 0,624); tỷ lệ sảy thai là 8% so với 7,95% (p = 0,95).
Kết luận: Kết quả chuyển đơn phôi nguyên bội thông qua tỷ lệ Beta HCG dương, thai lâm sàng và thai diễn tiến không có khác biệt mang ý nghĩa thống kê giữa hai nhóm, với độ tin cậy 95%.
ANALISIS PENINGKATAN KUALITAS PELAYANAN MENGGUNAKAN METODE SERVICE QUALITY ( SERVQUAL ) (Study Kasus Wisata Pulau Dodola Kabupaten Pulau Mototai)
Authors: Umar Almukmin , Sibua Amrin , Saleh Hasrul , Budi Prasetyo Nurtjahyo , Zulfikram Zulfikram , Jurtulis Niga 
Published: December 2023

Dodola Island Tourism is one of the tourist destinations located on Dodola Island, Morotai Island Kabupatean applies two Big Dodola Islands and Little Dodola. This study aims to determine the level of service quality and satisfaction of visitors or tourists in. Then find out how much influence the quality of service consisting of five dimensions, namely Physical Evidence, Reliability, Responsiveness, Assurance, Attention, on tourist satisfaction in Dodola Island Tourism with using Simple service quality (servqual) methods with SPSS tools. Data collection was carried out through literature study, field observation and questionnaire distribution to 25 respondents. The results of this study show that the level of service quality in Dodola Island Tourism is sufficient, while the level of tourist satisfaction is not good, because one dimension, namely Physical Evidence, is included in the category of not good. Therefore, Dodola Island Tourism needs to improve physical evidence is a dimension that has a limited presentation, which is 0.9698. This means that it is in the category of not good and is in the interval range of 0.9671, that is, it is in perception and expectation. Significantly to the satisfaction of tourists on Dodola Island Tourism.
Non-valvular infective endocarditis associated with central venous catheter bloodstream infection: a case report
Authors: Velarde-Acosta Kevin , Medina-Maguiña José M. , Anicama Lima William Efraín , Baltodano-Arellano Roberto 
Published: December 2023

Non-valvular Infective endocarditis (IE) is exceedingly rare; however, its incidence has risen in tandem with the increased usage of intracardiac devices and the growing prevalence of risk factors associated with IE. We present a clinical case involving an 18-year-old patient with IE occurring at an atypical location, concomitant with central venous catheter bloodstream infection. The patient underwent targeted antibiotic therapy but ultimately required surgical resection of the vegetation due to multiple risk factors associated with a poor prognosis. This case underscores the importance of maintaining a low threshold of suspicion for IE and emphasizes the need for heightened vigilance regarding non-valvular tissues hosting foreign bodies. These less common locations pose a risk for vegetation development. Additionally, we underscore the pivotal role of 3D echocardiography tools in anatomically characterizing the vegetation, including dimensions, implantation area, and related anatomy. These tools provide realistic images that facilitate informed decision-making. Furthermore, the timely selection of surgical intervention in patients at elevated risk of therapeutic failure is a cornerstone in effective management.