bluuebunny/crossref_metadata_2025_split huggingface dataset:
ГІДРОТЕРАПІЯ ПРИ М’ЯЗОВО-СКЕЛЕТНІЙ РЕАБІЛІТАЦІЇ В УМОВАХ ВІЙСЬКОВИХ ДІЙ НА ТЕРИТОРІЇ УКРАЇНИ
Authors: Салайда І. М. , Коваль В. Б. , Попович Д. В. 
Published: October 2023

РЕЗЮМЕ. Мета – провести аналітичний огляд сучасної медичної вітчизняної та зарубіжної літератури щодо можливостей застосування води як засобу фізичної реабілітації для осіб, що її потребують.
Матеріал і методи. При проведенні дослідження використано дані українських і зарубіжних джерел літератури щодо використання властивостей води та її застосування для реабілітації різнопрофільних пацієнтів.
Результати. Водне середовище має широкий реабілітаційний потенціал, починаючи від лікування гострих травм, поранень та підтримки здоров’я при перебігу хронічних захворювань, проте цей метод лікування залишається недооціненим у сучасних клінічних умовах. Існує велика дослідницька база даних щодо застосування водної терапії як в науковій теоретичній, так і в клінічній літературі. Ми описали різноманітність фізіологічних змін, які відбуваються під час водного занурення пацієнта. Завдяки широкій межі терапевтичної безпеки та клінічної адаптації гідротерапія є дуже корисним інструментом у реабілітаційній практиці. Краще розуміння практичними лікарями застосування цього методу відновлення дає можливість організувати відповідні терапевтичні програми лікування для різнопрофільних пацієнтів, в тому числі потерпілих (військовиків та цивільних) в результаті бойових дій в Україні.
Висновки. Гідротерапія є корисною для лікування пацієнтів з проблемами опорно-рухового апарату (бойові ураження кулями, фрагментами мін, гранат, металевих конструкцій, при ампутаціях кінцівок), неврологічними проблемами (посттравматичний синдром), патологією серцево-легеневої системи та іншими станами. Крім того, межа терапевтичної безпеки при використанні цього методу значно ширша, ніж практично будь-якого іншого, що застосовується в клініці. Знання біологічних ефектів застосування води може допомогти кваліфікованому реабілітаційному клініцисту створити оптимальний план комплексного лікування, шляхом відповідної модифікації гідро-статичного тиску води, її температурного режиму, меж занурення тіла та тривалості лікувального процесу в кожному конкретному випадку.
ПОКАЗНИКИ БІЛКОВОГО І ВУГЛЕВОДНОГО ОБМІНІВ У БІЛИХ ЩУРІВ ПРИ ВЖИВАННІ ПИТНОЇ ВОДИ З РІЗНИМ ВМІСТОМ ІОНІВ НАТРІЮ І КАЛІЮ
Authors: Мисула І. Р. , Лотоцький В. В. 
Published: October 2023

Резюме. З питною водою в організм споживачів можуть надходити різні макро- і мікроелементи. Їх нестача або понаднормова кількість може викликати серйозні проблеми зі здоров'ям. До таких елементів належать іони натрію і калію, які дуже поширені у довкіллі та є одними з головних іонів питної води.
Мета – оцінити вплив питної води з різним вмістом іонів натрію і калію на білковий та вуглеводний обмін в організмі білих щурів.
Матеріал і методи. Дослідження проведено на 72 білих щурах, поділених на 6 груп по 12 особин у кожній, які відрізнялися між собою за якістю питної води. 1-а група була контрольна. Тварини 2-ї групи споживали воду з вмістом іонів Na+ в концентрації 100,0 мг/л, 3-ї групи – з іонами К+ у концентрації 10,0 мг/л, 4-ї групи – з добавкою Na+ в концентрації 100,0 мг/л і К+ 10,0 мг/л, 5-ї − відповідно Na+ 50,0 мг/л і К+ 5,0 мг/л, 6-ї – Na+ 25,0 і К+ 2,5 мг/л. На 15 та 30 добу від початку досліду за допомогою напівавтоматичного біохімічного аналізатора “Humalyzer 2000” у сироватці крові визначали рівень загального білка, сечовини, креатиніну, глюкози і піровиноградної кислоти.
Результати. Вживання питної води з іонами калію у концентрації 10,0 мг/л та іонами натрію у концентрації 100,0 мг/л, як ізольовано, так і в комбінації, викликає достовірні зміни вмісту загального білка, креатиніну, сечовини та глюкози в сироватці крові щурів як на 15-у, так і на 30-у добу експерименту. Максимально виражена гіперглікемія виникає при вживанні водно-сольового розчину з концентрацією іонів натрію 100,0 мг/л. Зменшення концентрацій обох іонів до 25,0 мг/л (натрій) і 2,5 мг/л (калій) у питній воді не викликало змін показників білкового і вуглеводного обмінів в організмі тварин.
Висновки. Питна вода з різним вмістом іонів натрію і калію негативно впливає на організм щурів, викликаючи зміни в білковому та вуглеводному обмінах. Інтенсивність змін залежала від концентрації іонів у питній воді та тривалості її вживання.
Lipoprotein Characteristics and Incident Coronary Heart Disease: Prospective Cohort of Nearly 90 000 Individuals in UK Biobank
Authors: Jin Danyao , Trichia Eirini , Islam Nazrul , Bešević Jelena , Lewington Sarah , Lacey Ben 
Published: October 2023

Background
Associations of coronary heart disease (CHD) with plasma lipids are well described, but the associations with characteristics of lipoproteins (which transport lipids) remain unclear.

Methods and Results

UK Biobank is a prospective study of 0.5 million adults. Analyses were restricted to 89 422 participants with plasma lipoprotein and apolipoprotein measures from Nightingale nuclear magnetic resonance spectroscopy and without CHD at baseline. CHD risk was positively associated with concentrations of very‐low‐density lipoproteins, intermediate‐density lipoproteins, and low‐density lipoproteins (LDL), and inversely associated with high‐density lipoproteins. Hazard ratios (99% CIs) per SD were 1.22 (1.17–1.28), 1.16 (1.11–1.21), 1.20 (1.15–1.25), and 0.90 (0.86–0.95), respectively. Larger subclasses of very‐low‐density lipoproteins were less strongly associated with CHD risk, but associations did not materially vary by size of LDL or high‐density lipoprotein. Given lipoprotein particle concentrations, lipid composition (including cholesterol) was not strongly related to CHD risk, except for triglyceride in LDL particles. Apolipoprotein B was highly correlated with LDL concentration (
r
=0.99), but after adjustment for apolipoprotein B, concentrations of very‐low‐density lipoprotein and high‐density lipoprotein particles remained strongly related to CHD risk.

Conclusions
This large‐scale study reliably quantifies the associations of nuclear magnetic resonance–defined lipoprotein characteristics with CHD risk. CHD risk was most strongly related to particle concentrations, and separate measurements of lipoprotein concentrations may be of greater value than the measurement by apolipoprotein B, which was largely determined by LDL concentration alone. Furthermore, there was strong evidence of positive association with mean triglyceride molecules per LDL particle but little evidence of associations with total triglycerides or other lipid and lipoprotein fractions after accounting for lipoprotein concentrations.
Iodine‐Induced Hypothyroidism and Long‐Term Risks of Incident Heart Failure
Authors: Inoue Kosuke , Guo Rong , Lee Martin L. , Neverova Natalia V. , Ebrahimi Ramin , Currier Jesse W. , Bashir Muhammad T. , Leung Angela M. 
Published: October 2023

Background
Although most individuals can adapt to a large iodine load and remain euthyroid, hypothyroidism can develop after iodine exposure. Hypothyroidism is associated with adverse cardiovascular consequences, including heart failure. This study was performed to investigate the relationships between iodine‐induced hypothyroidism and incident heart failure.

Methods and Results

This cohort study of the US Veterans Health Administration (1998–2021) included adults aged ≥18 years with a serum thyroid‐stimulating hormone (thyrotropin) <60 days of iodine contrast administration, and <1 year of a baseline normal serum thyroid‐stimulating hormone. Cox proportional hazards regression ascertained risk of incident heart failure following iodine‐induced hypothyroidism, adjusting for age, sex, race and ethnicity, body mass index, and history of coronary heart disease, dyslipidemia, diabetes, and hypertension. Of 45 470 veterans (mean±SD age, 61.1±14.1 years; 88% men), 3361 (7.4%) developed iodine‐induced hypothyroidism. Heart failure developed in 5685 (12.5%) individuals over a median follow‐up of 3.6 years (interquartile range, 1.9–7.2 years). Adjusted for risk factors, iodine‐induced hypothyroidism was associated with increased risk of heart failure, compared with those who remained euthyroid after iodine exposure (adjusted hazard ratio [HR], 1.11 [95% CI, 1.01–1.22]). Women were at greater risk than men (adjusted HR: women, 1.65 [95% CI, 1.13–2.40]; men, 1.08 [95% CI, 0.98–1.19];
P
for interaction, 0.02).

Conclusions
In the largest US study of this topic, hypothyroidism following iodine exposure was associated with an increased risk of incident heart failure, particularly in women. These findings support the need for further research to address the clinical significance of this issue, including the possible sex‐specific risks of incident heart failure in more diverse data sets and study populations.
Conceptualising “Relocation” Across Displacement Contexts
Authors: Cantor David James 
Published: October 2023

Abstract
Planned relocations often take place in displacement contexts. They ensue not only in settings of disasters and climate change, but also during armed conflicts and in development projects. But what is ‘relocation’? Is its meaning identical across these diverse contexts? And what is its relationship to displacement? Conceptual clarity on these points is needed if humanitarians are to engage with the critical question of how international law regulates such relocation processes. This article reviews scholarly, policy and legal sources on relocations across these varied contexts in order to (i) propose a universal concept of relocation and (ii) reflect on its relationship to concepts of displacement. Then, by considering the issue in relation to internal displacement frameworks, the article explains how international law governs relocations, regardless of the specific setting in which they occur. This has important implications in a world of diverse, and often entwined, displacement contexts.
The effect of nebulized heparin on clinical outcomes in mechanically ventilated patients: a meta-analysis and review of the literature
Authors: Zhang Yi , Li Qiankun , Sun Changan , Gu Yue , Qi Zhijiang , Li Jun 
Published: October 2023

Objective To determine the relationship between use of nebulized heparin and clinical outcomes in mechanically ventilated patients. Methods The Medline, Embase, Web of Science, Cochrane Library, and PubMed databases were searched for relevant randomized controlled trials (RCTs), published between database inception and May 2022. Primary outcomes were intensive care unit (ICU) length of stay and in-hospital mortality; secondary outcomes included duration of mechanical ventilation, ventilator-free days (VFDs) in 28 days, and length of hospitalization. The study protocol was registered on PROSPERO (registration No: CRD42022345533). Results A total of eight RCTs (651 patients) were included. Nebulized heparin was associated with reduced ICU length of stay (six studies; mean difference [MD] –1.10, 95% confidence interval [CI] –1.87, –0.33, I2 = 76%), reduced duration of mechanical ventilation (two studies; MD –2.63, 95% CI –3.68, –1.58, I2 = 92%) and increased VFDs in 28 days (two studies; MD 4.22, 95% CI 1.10, 7.35, I2 = 18%), without increased incidence of adverse events, such as bleeding; but was not associated with a reduction in length of hospitalization (three studies; MD –1.00, 95% CI –2.90, –0.90, I2 = 0%) or in-hospital mortality (five studies; odds ratio 1.10, 95% CI 0.69, 1.77, I2 = 0%). Conclusion Nebulized heparin reduces ICU length of stay and duration of mechanical ventilation in mechanically ventilated patients, but has no effect on length of hospitalization or mortality.
A modified method for measuring the length of peripherally inserted central catheters to reduce the risk of malposition during catheter insertion
Authors: Yeh Tung-Chi , Chen Chia-Min , Cheng Chih-Hung , Sheu Chau-Chyun , Tsai Ming-Ju , Chang Wei-An 
Published: October 2023

Background: Malposition may occur during peripherally inserted central catheter insertion. Accurately measuring the length of a peripherally inserted central catheter is crucial to preventing malposition, including “long peripherally inserted central catheter placement,” in which the tip of a peripherally inserted central catheter is deeper than the target position. The traditional method of measuring peripherally inserted central catheter length involves measuring from the insertion site to the parasternal notch and down to the third or fourth intercostal space, which may result in overestimation because of the thickness of the pectoralis major and anterior chest wall. To avoid this overestimation, the authors developed and tested a modified method for reducing long peripherally inserted central catheter placement. Methods: This study employed a retrospective design. Chest X-rays were used to examine the peripherally inserted central catheter tip positions in 48 patients in the medical intensive care unit who had undergone peripherally inserted central catheter insertion. The traditional and modified measurement methods were used to measure the peripherally inserted central catheter length in 17 and 31 patients, respectively. Fisher’s exact test was used to examine between-group differences in the incidence of different types of peripherally inserted central catheter malposition. Results: The peripherally inserted central catheter tip position was near the target position in five patients (29.41%) in the traditional measurement group and 17 patients (54.84%) in the modified measurement group ( p = 0.132), whereas long peripherally inserted central catheter placement occurred in six patients (35.29%) in the traditional measurement group and one patient (3.23%) in the modified measurement group ( p = 0.006). However, the incidence of other types of peripherally inserted central catheter malposition did not differ significantly between the groups. Conclusions: The results of this study that the proposed modified measurement method may be able to reduce the incidence of long peripherally inserted central catheter placement among medical intensive care unit patients. The method must be further evaluated in prospective studies and studies with larger sample sizes in the future.
Effects of isoflurane and urethane anesthetics on glutamate neurotransmission in rat brain using in vivo amperometry
Authors: Beitchman Joshua A. , Krishna Gokul , Bromberg Caitlin E. , Thomas Theresa Currier 
Published: October 2023

Abstract
Background
Aspects of glutamate neurotransmission implicated in normal and pathological conditions are predominantly evaluated using in vivo recording paradigms in rats anesthetized with isoflurane or urethane. Urethane and isoflurane anesthesia influence glutamate neurotransmission through different mechanisms; however, real-time outcome measures of potassium chloride (KCl)-evoked glutamate overflow and glutamate clearance kinetics have not been compared within and between regions of the brain. In order to maintain rigor and reproducibility within the literature between the two most common methods of anesthetized in vivo recording of glutamate, we compared glutamate signaling as a function of anesthesia and brain region in the rat strain most used in neuroscience.

Methods
In the following experiments, in vivo amperometric recordings of KCl-evoked glutamate overflow and glutamate clearance kinetics (uptake rate and T80) in the cortex, hippocampus, and thalamus were performed using glutamate-selective microelectrode arrays (MEAs) in young adult male, Sprague-Dawley rats anesthetized with either isoflurane or urethane.

Results
Potassium chloride (KCl)-evoked glutamate overflow was similar under urethane and isoflurane anesthesia in all brain regions studied. Analysis of glutamate clearance determined that the uptake rate was significantly faster (53.2%, p < 0.05) within the thalamus under urethane compared to isoflurane, but no differences were measured in the cortex or hippocampus. Under urethane, glutamate clearance parameters were region-dependent, with significantly faster glutamate clearance in the thalamus compared to the cortex but not the hippocampus (p < 0.05). No region-dependent differences were measured for glutamate overflow using isoflurane.

Conclusions
These data support that amperometric recordings of KCl-evoked glutamate under isoflurane and urethane anesthesia result in similar and comparable data. However, certain parameters of glutamate clearance can vary based on choice of anesthesia and brain region. In these circumstances, special considerations are needed when comparing previous literature and planning future experiments.
Association of glycemic control with hypertension in patients with diabetes: a population-based longitudinal study
Authors: Chen Shengliang , Zhu Yi , Jin Sihui , Zhao Dongbao , Guo Jianwei , Chen Lijin , Huang Yixiang 
Published: October 2023

Abstract
Background
Diabetes increases the risk of hypertension morbidity, but whether this association is varied with glycemic control remains unknown. We aimed to examine the association of glycemic control with hypertension among individuals with diabetes.

Methods
Data was from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2018. Participants were categorized as having adequate glycemic control (HbA1c < 7%) and inadequate glycemic uncontrol (HbA1c ≥ 7%) by combining blood glucose tests and physician’s diagnoses in 2011. Incident hypertension was ascertained through self-reported physician diagnoses from 2011 to 2018. Cox proportional hazards regression models were used to examine the effect of glycemic control on hypertension.

Results
Among 436 participants with diabetes in this study, 102 met the glycemic control standard, and 334 were insufficient glycemic control. During 7 years of follow-up, 141 individuals developed hypertension. Compared with adequate glycemic control, the hazard ratio of inadequate glycemic control on hypertension was 1.54 (95% CI, 1.07–2.21) in the multivariate model. Additionally, the influence of glycemic control on hypertension varied based on educational attainment and the presence of depressive symptoms (P for interaction < 0.05).

Conclusions
Insufficient glycemic control was associated with a higher risk of hypertension among individuals with diabetes. Notably, the effect of glycemic control on hypertension was more pronounced among those with lower educational attainment and those exhibiting depressive symptoms. These findings underscore the significance of vigilant glycemic monitoring, educational background considerations, and mental health assessments in managing diabetic individuals.
Relationship between quantitative epicardial adipose tissue based on coronary computed tomography angiography and coronary slow flow
Authors: Tong Jing , Bei Gui-Guang , Zhang Li-Bo , Sun Yu , Qi Miao , Yang Ben-Qiang 
Published: October 2023

AbstractBackgroundThe purpose of this study was to explore the relationship between quantitative epicardial adipose tissue (EAT) based on coronary computed tomography angiography (CCTA) and coronary slow flow (CSF).MethodsA total of 85 patients with < 40% coronary stenosis on diagnostic coronary angiography were included in this retrospective study between January 2020 and December 2021. A semi-automatic method was developed for EAT quantification on CCTA images. According to the thrombolysis in myocardial infarction flow grade, the patients were divided into CSF group (n = 39) and normal coronary flow group (n = 46). Multivariate logistic regression was used to explore the relationship between EAT and CSF. Receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic value of EAT in CSF.ResultsEAT volume in the CSF group was significantly higher than that of the normal coronary flow group (128.83± 21.59 mL vs. 101.87± 18.56 mL, P < 0.001). There was no significant difference in epicardial fat attenuation index between the two groups (P > 0.05). Multivariate logistic regression analysis showed that EAT volume was independently related to CSF [odds ratio (OR) = 4.82, 95% confidence interval (CI): 3.06–7.27, P < 0.001]. The area under ROC curve for EAT volume in identifying CSF was 0.86 (95% CI: 0.77–0.95). The optimal cutoff value of 118.46 mL yielded a sensitivity of 0.80 and a specificity of 0.94.ConclusionsIncreased EAT volume based on CCTA is strongly associated with CSF. This preliminary finding paves the way for future and larger studies aimed to definitively recognize the diagnostic value of EAT in CSF.
Adjusting for Berkson error in exposure in ordinary and conditional logistic regression and in Poisson regression
Authors: Oraby Tamer , Chakraborty Santanu , Sivaganesan Siva , Kincl Laurel , Richardson Lesley , McBride Mary , Siemiatycki Jack , Cardis Elisabeth , Krewski Daniel 
Published: October 2023

Abstract
Background
INTEROCC is a seven-country cohort study of occupational exposures and brain cancer risk, including occupational exposure to electromagnetic fields (EMF). In the absence of data on individual exposures, a Job Exposure Matrix (JEM) may be used to construct likely exposure scenarios in occupational settings. This tool was constructed using statistical summaries of exposure to EMF for various occupational categories for a comparable group of workers.

Methods
In this study, we use the Canadian data from INTEROCC to determine the best EMF exposure surrogate/estimate from three appropriately chosen surrogates from the JEM, along with a fourth surrogate based on Berkson error adjustments obtained via numerical approximation of the likelihood function. In this article, we examine the case in which exposures are gamma-distributed for each occupation in the JEM, as an alternative to the log-normal exposure distribution considered in a previous study conducted by our research team. We also study using those surrogates and the Berkson error adjustment in Poisson regression and conditional logistic regression.

Results
Simulations show that the introduced methods of Berkson error adjustment for non-stratified analyses provide accurate estimates of the risk of developing tumors in case of gamma exposure model. Alternatively, and under some technical assumptions, the arithmetic mean is the best surrogate when a gamma-distribution is used as an exposure model. Simulations also show that none of the present methods could provide an accurate estimate of the risk in case of stratified analyses.

Conclusion
While our previous study found the geometric mean to be the best exposure surrogate, the present study suggests that the best surrogate is dependent on the exposure model; the arithmetic means in case of gamma-exposure model and the geometric means in case of log-normal exposure model. However, we could present a better method of Berkson error adjustment for each of the two exposure models. Our results provide useful guidance on the application of JEMs for occupational exposure assessments, with adjustment for Berkson error.