bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extending scene-to-patch models: Multi-resolution multiple instance learning for Earth observation
Authors: Early Joseph , Deweese Ying-Jung Chen , Evers Christine , Ramchurn Sarvapali 
Published: December 2023

Abstract
Land cover classification (LCC) and natural disaster response (NDR) are important issues in climate change mitigation and adaptation. Existing approaches that use machine learning with Earth observation (EO) imaging data for LCC and NDR often rely on fully annotated and segmented datasets. Creating these datasets requires a large amount of effort, and a lack of suitable datasets has become an obstacle in scaling the use of machine learning for EO. In this study, we extend our prior work on Scene-to-Patch models: an alternative machine learning approach for EO that utilizes Multiple Instance Learning (MIL). As our approach only requires high-level scene labels, it enables much faster development of new datasets while still providing segmentation through patch-level predictions, ultimately increasing the accessibility of using machine learning for EO. We propose new multi-resolution MIL architectures that outperform single-resolution MIL models and non-MIL baselines on the DeepGlobe LCC and FloodNet NDR datasets. In addition, we conduct a thorough analysis of model performance and interpretability.
Short-term forecasting of ozone air pollution across Europe with transformers
Authors: Hickman Sebastian H. M. , Griffiths Paul T. , Nowack Peer J. , Archibald Alexander T. 
Published: December 2023

Abstract
Surface ozone is an air pollutant that contributes to hundreds of thousands of premature deaths annually. Accurate short-term ozone forecasts may allow improved policy actions to reduce the risk to human health. However, forecasting surface ozone is a difficult problem as its concentrations are controlled by a number of physical and chemical processes that act on varying timescales. We implement a state-of-the-art transformer-based model, the temporal fusion transformer, trained on observational data from three European countries. In four-day forecasts of daily maximum 8-hour ozone (DMA8), our novel approach is highly skillful (MAE = 4.9 ppb, coefficient of determination

$ {\mathrm{R}}^2=0.81 $

) and generalizes well to data from 13 other European countries unseen during training (MAE = 5.0 ppb,

$ {\mathrm{R}}^2=0.78 $

). The model outperforms other machine learning models on our data (ridge regression, random forests, and long short-term memory networks) and compares favorably to the performance of other published deep learning architectures tested on different data. Furthermore, we illustrate that the model pays attention to physical variables known to control ozone concentrations and that the attention mechanism allows the model to use the most relevant days of past ozone concentrations to make accurate forecasts on test data. The skillful performance of the model, particularly in generalizing to unseen European countries, suggests that machine learning methods may provide a computationally cheap approach for accurate air quality forecasting across Europe.
Media, Cultural Techniques, and the Law: The Other Cornelia Vismann
Authors: Minkkinen Panu 
Published: December 2023

AbstractIn the Anglophone world of law, the German legal historian and legal theorist Cornelia Vismann (1961–2010) is best known as an acute interpreter of French high theory, especially of Jacques Derrida, Jacques Lacan, and Michel Foucault. This type of reception is, I argue, somewhat distorted. For her English-speaking colleagues, French “poststructuralism” provides the interface that enables Vismann to enter into shared discursive constellations with her Anglo-American critical legal colleagues. But at the same time, such a reception also downplays the very specifically German soil from which her unique scholarship arose. This Article discusses Vismann’s German background as media theory, the discipline that she was mostly associated with by her compatriots. The Article then assesses what Vismann’s media-theoretical contributions potentially offer to the contemporary study of law. For this “other Vismann,” the media-theoretical study of law was, I suggest, a practically oriented critical discipline that focused on law’s “cultural techniques” and how they operated. I also briefly touch upon what is generally known as “German media theory” through key figures such as Friedrich A. Kittler and Bernhard Siegert.
The relationship between the permeability and liquid water content of polycrystalline temperate ice
Authors: Fowler Jacob R. , Iverson Neal R. 
Published: December 2023

AbstractTo better constrain meltwater transport and ice viscosity in temperate glaciers, particularly in ice stream shear margins, we use a custom permeameter to study the untested model relationship between the permeability of temperate ice and its liquid water content. The permeability of lab-made ice of two mean grain diameters (1.8 and 4.2 mm) is measured, and water content is controlled with the ice salinity and measured calorimetrically. Fluorescein dye is added to through-flowing, chilled water to highlight flow pathways through the ice after experiments. As predicted by a simple model, permeability increases with approximately the square of the water content and by about three orders of magnitude across water contents of 0.1–4.4%. However, permeability values are less than those of the model by average factors of 2.6 and 4.1 for the finer and coarser ice, respectively. This discrepancy is likely due to tortuous, truncated or air-clogged veins. The order-of-magnitude agreement between measured and modeled values may indicate that reduced permeability from these factors is nearly compensated by preferential flow in oversized veins that are isolated or arborescent. Both kinds of preferred flow pathways are observed but the latter only in fine-grained ice at water contents > 2%.
Functional and phylogenetic metrics to evaluate the potential of flagship species: the case of the salamander Ambystoma ordinarium
Authors: Suazo-Ortuño Ireri , Benítez-Malvido Julieta , Oropeza-Sánchez Marco Tulio 
Published: December 2023

Abstract
Flagship species are those chosen to raise support for broader conservation marketing campaigns and can be used as symbols of the ecosystem services and evolutionary history of particular areas. Thus, flagship species can be employed for the protection of endangered species and threatened ecosystems. Northeastern Michoacán, Mexico, is an important region for amphibian diversity but approximately 40% of its mature forest has been removed. Among northeastern Michoacán amphibians, the use of Ambystoma ordinarium as a flagship species is supported by its co-occurrence with other threatened amphibians along riparian zones. To support this proposal, however, it is important to assess the functional traits and evolutionary history of amphibian species sharing their habitat with A. ordinarium. To evaluate the potential of A. ordinarium as a flagship species, we estimated the functional and phylogenetic diversity of amphibian assemblages in 60 riparian zones. The results showed that amphibian assemblages sharing habitat with A. ordinarium presented higher functional and phylogenetic diversity than those in which this species was absent. These results highlight the potential of A. ordinarium as a flagship species for the protection of associated amphibian species, their functions, and evolutionary history.
The Effectiveness of Prehospital Subcutaneous Continuous Lactate Monitoring in Adult Trauma: A Systematic Review
Authors: Scriven Jamie W. , Battaloglu Emir 
Published: December 2023

AbstractIntroduction:Existing diagnostics for polytrauma patients continue to rely on non-invasive monitoring techniques with limited sensitivity and specificity for critically unwell patients. Lactate is a known diagnostic and prognostic marker used in infection and trauma and has been associated with mortality, need for surgery, and organ dysfunction. Point-of-care (POC) testing allows for the periodic assessment of lactate levels; however, there is an associated expense and equipment burden associated with repeated sampling, with limited feasibility in prehospital care. Subcutaneous lactate monitoring has the potential to provide a dynamic assessment of physiological lactate levels and utilize these trends to guide management and response to given treatments.Study Objective:The aim of this study was to appraise the current literature on dynamic subcutaneous continuous lactate monitoring (SCLM) in adult trauma patients and its use in lactate-guided therapy in the prehospital environment.Methods:The systematic review was conducted in accordance with the PRISMA guidelines and registered with PROSPERO. Searched databases included PubMed, EMBASE via Ovid SP, Cochrane Library, and Web of Science. Databases were searched from inception to March 29, 2022. Relevant manuscripts were further scrutinized for reference citations to interrogate the fullness of the adjacent literature.Results:Searches returned 600 studies, including 551 unique manuscripts. Following title and abstract screening, 14 manuscripts met the threshold for full-text sourcing. Subsequent to the scrutiny of all 14 manuscripts, none fully met the specified eligibility criteria. Following careful examination, no article was found to cover the exact area of scientific inquiry due to disparity in technological or environmental characteristics.Conclusion:Little is known about the utility of dynamic subcutaneous lactate monitoring, and this review highlights a clear gap in current literature. Novel subcutaneous lactate monitors are in development, and the literature describing the prototype experimentation has been summarized. These studies demonstrate device accuracy, which shows a close correlation with venous lactate while providing dynamic readings without significant lag times. Their availability and cost remain barriers to implementation at present. This represents a clear target for future feasibility studies to be conducted into the clinical use of dynamic subcutaneous lactate monitoring in trauma and resuscitation.
Was global deforestation under lockdown?
Authors: Saavedra Santiago 
Published: December 2023

AbstractThe COVID-19 pandemic and government responses led to a halt in economic activity. While this reduced pollution in urban areas, its effect on deforestation in areas outside of cities is unclear. Deforestation may have decreased due to the restrictions on economic activity, but, it may have increased due to the drying up of alternative income sources. We analyzed bi-weekly data on tropical forests worldwide in relation to the dates when different countries implemented lockdown restrictions. Our analysis found that while lockdowns did reduce mobility in forest municipalities, the average effect on deforestation was not significant. However, we did observe variations in the impact of lockdowns on deforestation based on the share of lockdown-vulnerable GDP and the level of government effectiveness. These results stand across tropical countries and within Colombia. These findings highlight the importance of alternative income sources and strong state capacity for effective policies aimed at reducing deforestation.
Globalisation and mental health: is globalisation good or bad for mental health? Testing for quadratic effects
Authors: Amin Saqib 
Published: December 2023

AbstractThis paper explores the relationship between globalisation and mental health by using the global dataset of high-, middle-, and low-income countries for the period 1970–2020. Although the consequences of globalisation on general health have been extensively studied, limited attention has been paid to investigating the implications on mental health. To show robustness, globalisation has been divided into three main dimensions such as economic globalisation, political globalisation, and social globalisation while, mental health has been classified through various indicators, i.e., mental disorder, anxiety disorder, and depressive disorder. The study used panel fixed effect techniques to demonstrate the quadratic effects of globalisation on mental health. A U-shaped curve relationship between globalisation (including economic, political, and political globalisation) and mental disorders, anxiety disorders, and depressive disorders was identified. However, findings also indicate an inverted U-shaped curve relationship between globalisation and mental health for high-income countries and a U-shaped curve relationship for middle- and low-income countries. Prioritizing mental health is crucial for overall well-being and productivity. Furthermore, a comprehensive policy implementation is strongly recommended to protect societies from mental distress when a country plans to expand globalisation worldwide.
Source of Radio Emissions Induced by the Galilean Moons Io, Europa and Ganymede: In Situ Measurements by Juno
Authors: Louis C. K. , Louarn P. , Collet B. , Clément N. , Al Saati S. , Szalay J. R. , Hue V. , Lamy L. , Kotsiaros S. , Kurth W. S. , Jackman C. M. , Wang Y. , Blanc M. , Allegrini F. , Connerney J. E. P. , Gershman D. 
Published: December 2023

AbstractAt Jupiter, part of the auroral radio emissions are induced by the Galilean moons Io, Europa and Ganymede. Until now, except for Ganymede, they have been only remotely detected, using ground–based radio–telescopes or electric antennas aboard spacecraft. The polar trajectory of the Juno orbiter allows the spacecraft to cross the range of magnetic flux tubes which sustain the various Jupiter–satellite interactions, and in turn to sample in situ the associated radio emission regions. In this study, we focus on the detection and the characterization of radio sources associated with Io, Europa and Ganymede. Using electric wave measurements or radio observations (Juno/Waves), in situ electron measurements (Juno/JADE–E), and magnetic field measurements (Juno/MAG) we demonstrate that the Cyclotron Maser Instability (CMI) driven by a loss–cone electron distribution function is responsible for the encountered radio sources. We confirmed that radio emissions are associated with Main (MAW) or Reflected Alfvén Wing (RAW), but also show that for Europa and Ganymede, induced radio emissions are associated with Transhemispheric Electron Beam (TEB). For each traversed radio source, we determine the latitudinal extension, the CMI–resonant electron energy, and the bandwidth of the emission. We show that the presence of Alfvén perturbations and downward field–aligned currents are necessary for the radio emissions to be amplified.
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression
Authors: Leeman-Neill Rebecca J. , Song Dong , Bizarro Jonathan , Wacheul Ludivine , Rothschild Gerson , Singh Sameer , Yang Yang , Sarode Aditya Y. , Gollapalli Kishore , Wu Lijing , Zhang Wanwei , Chen Yiyun , Lauring Max C. , Whisenant D. Eric , Bhavsar Shweta , Lim Junghyun , Swerdlow Steven H. , Bhagat Govind , Zhao Qian , Berchowitz Luke E. , Lafontaine Denis L. J. , Wang Jiguang , Basu Uttiya 
Published: December 2023

AbstractWhole-genome sequencing of longitudinal tumor pairs representing transformation of follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements (double-hit lymphoma) identified coding and noncoding genomic alterations acquired during lymphoma progression. Many of these transformation-associated alterations recurrently and focally occur at topologically associating domain resident regulatory DNA elements, including H3K4me3 promoter marks located within H3K27ac super-enhancer clusters in B cell non-Hodgkin lymphoma. One region found to undergo recurrent alteration upon transformation overlaps a super-enhancer affecting the expression of the PAX5/ZCCHC7 gene pair. ZCCHC7 encodes a subunit of the Trf4/5-Air1/2-Mtr4 polyadenylation-like complex and demonstrated copy number gain, chromosomal translocation and enhancer retargeting-mediated transcriptional upregulation upon lymphoma transformation. Consequently, lymphoma cells demonstrate nucleolar dysregulation via altered noncoding 5.8S ribosomal RNA processing. We find that a noncoding mutation acquired during lymphoma progression affects noncoding rRNA processing, thereby rewiring protein synthesis leading to oncogenic changes in the lymphoma proteome.
Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases
Authors: Homilius Max , Zhu Wandi , Eddy Samuel S. , Thompson Patrick C. , Zheng Huahua , Warren Caleb N. , Evans Chiara G. , Kim David D. , Xuan Lucius L. , Nsubuga Cissy , Strecker Zachary , Pettit Christopher J. , Cho Jungwoo , Howie Mikayla N. , Thaler Alexandra S. , Wilson Evan , Wollison Bruce , Smith Courtney , Nascimben Julia B. , Nascimben Diana N. , Lunati Gabriella M. , Folks Hassan C. , Cupelo Matthew , Sridaran Suriya , Rheinstein Carolyn , McClennen Taylor , Goto Shinichi , Truslow James G. , Vandenwijngaert Sara , MacRae Calum A. , Deo Rahul C. 
Published: December 2023

AbstractAlthough genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular biological mechanisms remains challenging due to the complex nature of common diseases. We established a framework using human peripheral blood cells, physical, chemical and pharmacological perturbations, and flow cytometry-based functional readouts to reveal latent cellular processes and performed GWAS based on these evoked traits in up to 2,600 individuals. We identified 119 genomic loci implicating 96 genes associated with these cellular responses and discovered associations between evoked blood phenotypes and subsets of common diseases. We found a population of pro-inflammatory anti-apoptotic neutrophils prevalent in individuals with specific subsets of cardiometabolic disease. Multigenic models based on this trait predicted the risk of developing chronic kidney disease in type 2 diabetes patients. By expanding the phenotypic space for human genetic studies, we could identify variants associated with large effect response differences, stratify patients and efficiently characterize the underlying biology.
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes
Authors: Brahma Sandipan , Henikoff Steven 
Published: December 2023

AbstractChromatin accessibility is a hallmark of active transcription and entails ATP-dependent nucleosome remodeling, which is carried out by complexes such as Brahma-associated factor (BAF). However, the mechanistic links between transcription, nucleosome remodeling and chromatin accessibility are unclear. Here, we used a chemical–genetic approach coupled with time-resolved chromatin profiling to dissect the interplay between RNA Polymerase II (RNAPII), BAF and DNA-sequence-specific transcription factors in mouse embryonic stem cells. We show that BAF dynamically unwraps and evicts nucleosomes at accessible chromatin regions, while RNAPII promoter-proximal pausing stabilizes BAF chromatin occupancy and enhances ATP-dependent nucleosome eviction by BAF. We find that although RNAPII and BAF dynamically probe both transcriptionally active and Polycomb-repressed genomic regions, pluripotency transcription factor chromatin binding confers locus specificity for productive chromatin remodeling and nucleosome eviction by BAF. Our study suggests a paradigm for how functional synergy between dynamically acting chromatin factors regulates locus-specific nucleosome organization and chromatin accessibility.
Comparative and phylogenetic analyses of nine complete chloroplast genomes of Orchidaceae
Authors: Liu Likuan , Du Jingxuan , Liu Zhihua , Zuo Wenming , Wang Zhenglei , Li Jinping , Zeng Yang 
Published: December 2023

AbstractThe orchid family has 200,000 species and 700 genera, and it is found worldwide in the tropics and subtropics. In China, there are 1247 species and subspecies of orchids belonging to the Orchidaceae family. Orchidaceae is one of the most diverse plant families in the world, known for their lush look, remarkable ecological tolerance, and capability for reproduction. It has significant decorative and therapeutic value. In terms of evolution, the orchid family is one of the more complicated groups, but up until now, little has been known about its affinities. This study examined the properties of 19 chloroplast (cp) genomes, of which 11 had previously been published and nine had only recently been revealed. Following that, topics such as analysis of selection pressure, codon usage, amino acid frequencies, repeated sequences, and reverse repeat contraction and expansion are covered. The Orchidaceae share similar cp chromosomal characteristics, and we have conducted a preliminary analysis of their evolutionary connections. The cp genome of this family has a typical tepartite structure and a high degree of consistency across species. Platanthera urceolata with more tandem repeats of the cp genome. Similar cp chromosomal traits can be seen in the orchidaceae. Galearis roborowskyi, Neottianthe cucullata, Neottianthe monophylla, Platanthera urceolata and Ponerorchis compacta are the closest cousins, according to phylogenetic study.
Contact with nature for emotion regulation: the roles of nature connectedness and beauty engagement in urban young adults
Authors: Gu Xuan , Zheng Hailin , Tse Chi-Shing 
Published: December 2023

AbstractContact with nature has emotional benefits, but the psychological mechanism and potential moderator underlying the association between nature contact and emotion regulation remain unclear. The present study investigated how self-reported frequency of nature contact is associated with the use of emotion regulation strategies and explored the mediating role of nature connectedness (i.e., psychological connection to nature) and the moderating role of engagement with natural beauty. Employing mediation and moderated mediation analyses, in a cross-sectional sample of 2097 young adults aged 18–35 years old (M = 24.01, SD = 4.80) residing in urban China, we obtained three major findings. First, nature connectedness mediated the associations between direct/indirect nature contact and cognitive reappraisal as well as expressive suppression. Second, engagement with natural beauty moderated the path from direct/indirect nature contact to cognitive reappraisal in the mediation models. Third, engagement with natural beauty moderated the path from indirect nature contact to nature connectedness in the mediation models. Our study is the first to reveal mediating and moderating factors in the relationships among direct/indirect contact with nature, nature connectedness, engagement with natural beauty, and emotion regulation strategies. These findings provide support for the emotional health of nature contact and have implications for nature-based education and urban planning.