bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategic Planning for Research Data Services
Authors: Briney Kristin 
Published: October 2023

EDITOR'S SUMMARYLibraries are increasingly being asked to provide data management support of various types. Without a single approach or standard, each institution must devise a strategic plan for data management support in terms of local requirements. A strategic plan helps to align available skills and services with the needs of users and to build critical support. Planning must start with research on user needs and any pertinent unique local information. Based on an explicit need, the plan should specify a vision for data services using identified resources for a specified time period. A strengths, weaknesses, opportunities and threats (SWOT) analysis can help to identify internal and external factors to be considered. Actionable and reasonable goals should be formulated and outlined. The strategic plan should encourage stakeholders to work in concert, include outcome metrics and be updated every few years.
Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma
Authors: Bisht Kamlesh , Fukao Taro , Chiron Marielle , Richardson Paul , Atanackovic Djordje , Chini Eduardo , Chng Wee Joo , Van De Velde Helgi , Malavasi Fabio 
Published: October 2023

AbstractBackgroundCD38 has been established as an important therapeutic target for multiple myeloma (MM), for which two CD38 antibodies are currently approved—daratumumab and isatuximab. CD38 is an ectoenzyme that degrades NAD and its precursors and is involved in the production of adenosine and other metabolites.AimAmong the various mechanisms by which CD38 antibodies can induce MM cell death is immunomodulation, including multiple pathways for CD38‐mediated T‐cell activation. Patients who respond to anti‐CD38 targeting treatment experience more marked changes in T‐cell expansion, activity, and clonality than nonresponders.ImplicationsResistance mechanisms that undermine the immunomodulatory effects of CD38‐targeting therapies can be tumor intrinsic, such as the downregulation of CD38 surface expression and expression of complement inhibitor proteins, and immune microenvironment‐related, such as changes to the natural killer (NK) cell numbers and function in the bone marrow niche. There are numerous strategies to overcome this resistance, which include identifying and targeting other therapeutic targets involved in, for example, adenosine production, the activation of NK cells or monocytes through immunomodulatory drugs and their combination with elotuzumab, or with bispecific T‐cell engagers.
Solvothermal Growth of Cu/Cu2O/NiFe Layered Double Hydroxide for Hydrogen Evolution from UV‐Visible‐Light‐Driven Water Splitting
Authors: Suppaso Chomponoot , Kanazawa Tomoki , Nozawa Shunsuke , Maeda Kazuhiko , Khaorapapong Nithima 
Published: October 2023

AbstractThe photocatalytic hydrogen production plays a key role as a potential process to generate an efficient energy. Because the demand of hydrogen energy is increasing in many chemical processes, the development of low cost photocatalyst has been gaining much attention in recent years. Layered double hydroxide is a two‐dimensional layered clay that has been widely used as a photocatalyst but suffers from low transportation of the charge carriers. To suppress the limitation, herein, the Cu/Cu2O/NiFe‐layered double hydroxide was synthesized by a facile solvothermal method. The aid of glycerol could be used to reduce Cu2+ and Fe3+ to Cu0/Cu+ and Fe2+, resulting in the increase of absorption in the visible‐light region. The glycerol concentration affected the formation of copper species. The Cu2CO3(OH)2/Cu2O was formed by using a 7.5 vol.% glycerol aqueous solution, then the Cu/Cu2O species formed when the glycerol concentration reached 30 vol.%. All copper species, i. e. CuO, Cu2CO3(OH)2, Cu and Cu2O could act as co‐catalysts and increased the photocatalytic activity of NiFe‐layered double hydroxide, where the most active species was Cu/Cu2O. The Cu/Cu2O/NiFe‐layered double hydroxide could generate hydrogen from water with the presence of methanol as a sacrificial reagent, with an apparent quantum yield of 0.53 % at 400 nm.
From One‐Dimensional Disordered Racemate to Ordered Racemic Conglomerates through Metal‐Coordination‐Driven Self‐Assembly at the Liquid‐Solid Interface
Authors: Hu Tianze , Minoia Andrea , Velpula Gangamallaiah , Ryskulova Kanykei , Van Hecke Kristof , Lazzaroni Roberto , Mali Kunal S. , Hoogenboom Richard , De Feyter Steven 
Published: October 2023

AbstractIn recent years, there has been significant focus on investigating and controlling chiral self‐assembly, specifically in the context of enantiomeric separation. This study explores the self‐assembly behavior of 4‐dodecyl‐3,6‐di(2‐pyridyl)pyridazine (DPP−C12) at the interface between heptanoic acid (HA) and highly oriented pyrolytic graphite (HOPG) using a combination of scanning tunneling microscopy (STM) and multiscale molecular modeling. The self‐assembled monolayer structure formed by DPP−C12 is periodic in one direction, but aperiodic in the direction orthogonal to it. These structures resemble 1D disordered racemic compounds. Upon introducing palladium [Pd(II)] ions, complexing with DPP−C12, these 1D disordered racemic compounds spontaneously transform into 2D racemic conglomerates, which is rationalized with the assistance of force‐field simulations. Our findings provide insights into the regulation of two‐dimensional chirality.
A Discrete, Boron‐Containing Triangular Triradical
Authors: Sun Quanchun , Chen Haowen , Zhao Yu , Wang Tao , Pei Runbo , Zhao Yue , Ye Shengfa , Wang Xinping 
Published: October 2023

AbstractA neutral boron‐containing triangular triradical based on a triptycene derivative has been designed and synthesized. Its structure, bonding and physical property have been studied by EPR spectroscopy, SQUID magnetometry and single crystal X‐ray diffraction, as well as theoretical calculations. The triradical has a series of isosceles triangle conformations in the solution due to the Jahn‐Teller distortion, leading to the splitting of the two low‐lying doublet states. This factor together with negligible spin‐orbit coupling (SOC) of composing light atoms quenches the spin frustration. The work represents a rare example of a neutral through‐space triangular triradical.
Pillar[5]arene‐Based Fluorescent Supramolecular Polymers Without Conventional Chromophores
Authors: Shao Li , Hua Bin , Zhao Xueru , Lu Shuai , Li Guangfeng 
Published: October 2023

AbstractFluorescent supramolecular polymers have garnered significant attention due to their successful integration of supramolecular polymers and fluorescence, offering vast potential for applications in sensing, imaging, optoelectronics, and photonics. In this study, we present a novel supramolecular polymer based on P5‐OH, derived from mono‐substituted pillararene macrocycles. Notably, these formed supramolecular polymeric aggregates exhibit a prominent blue emission, representing a rare instance of fluorescent polymers devoid of conventional chromophores. Furthermore, through the modification of alkyl chain ending groups attached to pillar[5]arenes, slight shifts in the emission peak could be observed. This research expands the scope of functional supramolecular polymeric systems utilizing pillararenes, providing valuable insights for the design of innovative luminescent materials and optical devices.
An integrated petrographical and geochemical study of the Tredian Formation in the Salt and Trans‐Indus Surghar ranges, North‐West Pakistan: Implications for palaeoclimate
Authors: Qureshi Kamil Ahmed , Rizwan Muhammad , Janjuhah Hammad Tariq , Islam Ihtisham , Kontakiotis George , Bilal Ahmer , Arif Mohamad 
Published: October 2023

AbstractThe Middle Triassic Tredian Formation is well exposed in the western region of the Salt Range. It is mostly composed of sandstone with minor alternations of shales and dolomite. This is the first integrated attempt using petrographical and geochemical features to reveal palaeoclimate during deposition of the Tredian Formation. This work sheds light on the petrographical and geochemical properties of the Tredian sandstone in order to date various layers and evaluate the palaeoclimate. The formation was sampled at two distinct stratigraphic layers for petrographic and geochemical analysis of major and trace elements. The sandstone of the Tredian Formation is sub‐feldspathic to feldspathic arenite with sub‐angular to rounded grains that are moderately to extensively sorted. The relative proportions of the quartz, feldspars and lithoclasts in the examined sandstone samples shows that the Tredian sediments originated from the interior of the craton during a transitional continental regime. Chemical index of alteration values of 59, chemical index of weathering values of 67, and plagioclase index of alteration values of 74.5 indicate a low to moderate degree of weathering in the Tredian sediment source region. Based on the silica content, SiO2/Al2O3 ratios (2.7–6.1; mean 4.1), and chemical maturity index, it is deduced that the Tredian Formation was deposited in chemically immature to sub‐mature and dry to semi‐arid conditions. Geochemical proxies indicate the acidic source of sediment and deposition on the passive margin of the Indian Plate. The trace element characteristics of the sediments, especially the Rb/Sr, Cu/Zn, Ni/Co, V/Cr and Sr/Ba ratios, indicate that the sediments originated from the first weathering cycle and support the notion that they were deposited in an oxidising continental environment. A semi‐arid to arid palaeoclimate predominated through the Middle Triassic at the north‐western passive continental margin of the Indian Plate in the south‐eastern Neo‐Tethys.
International Physical Activity Questionnaire Short Form and accelerometer‐assessed physical activity: concurrent validity using six cut‐points in HF patients
Authors: Blasco‐Peris Carles , Climent‐Paya Vicente , Vetrovsky Tomas , García‐Álvarez María I. , Manresa‐Rocamora Agustín , Beltrán‐Carrillo Vicente J. , Sarabia José Manuel 
Published: October 2023

AbstractAimsPhysical activity (PA) is an important target for improving clinical outcomes in heart failure (HF) patients. Nonetheless, assessing the daily PA profile in this population is a challenging task, traditionally performed using self‐report questionnaires such as the International PA Questionnaire Short Form (IPAQ‐SF). This study aimed to evaluate the concurrent validity of the IPAQ‐SF and accelerometer‐assessed PA using six published cut‐points in patients with HF and reduced or mildly reduced ejection fraction.Methods and resultsThe concordance between the IPAQ‐SF and a hip‐worn accelerometer regarding daily time spent performing moderate to vigorous PA in bouts of at least 10 min was assessed in 53 participants for seven consecutive days using six different cut‐points (Barnett, Dibben, Mark, Sanders, Troiano, and Vaha‐Ypya). Spearman's correlation and Bland–Altman plots were used to evaluate concurrent validity between methods. Regressions were used to study the association between patient variables, wear protocol (waking hour or 24 h), and absolute bias. The kappa index was used to evaluate the concordance between IPAQ‐SF and accelerometry for classifying patients as active or non‐active. All analyses were re‐run using non‐bouted metrics to investigate the effect of bouted versus non‐bouted analysis. The IPAQ‐SF and accelerometry showed low to negligible correlation (ρ = 0.12 to 0.37), depending on the cut‐point used. The regression analysis showed that the absolute bias was higher in participants following the waking‐hour protocol at all cut‐points except Dibben's (P ≤ 0.007). The concordance between the two methods to classify patients as active and non‐active was low when using Mark (κ = 0.23) and Barnett (κ = 0.34) cut‐points and poor for the remaining cut‐points (κ = 0.03 to 0.18). The results of the sensitivity analysis showed negligible to low correlation using non‐bouted metrics (ρ = 0.27 to 0.33).ConclusionsModerate to vigorous PA measures using IPAQ‐SF and accelerometers are not equivalent, and we do not encourage researchers to use IPAQ‐SF alone when assessing PA in HF patients. Moreover, applying personalized collection and processing criteria is important when assessing PA in HF patients. We recommend following the 24 h protocol and selecting cut‐points calibrated in patients with cardiovascular diseases. Finally, it is necessary to develop a new tailored questionnaire that considers walking intensity and is adjusted to the current World Health Organisation recommendations, which use non‐bouted metrics.
Exploring the impact of patient‐specific clinical features on osimertinib effectiveness in a real‐world cohort of patients with EGFR mutated non‐small cell lung cancer
Authors: van Veelen Ard , Veerman G. D. Marijn , Verschueren Marjon V. , Gulikers Judith L. , Steendam Christi M. J. , Brouns Anita J. W. M. , Dursun Safiye , Paats Marthe S. , Tjan‐Heijnen Vivianne C. G. , van der Leest Cor , Dingemans Anne‐Marie C. , Mathijssen Ron H. J. , van de Garde Ewoudt M. W. , Souverein Patrick , Driessen Johanna H. M. , Hendriks Lizza E. L. , van Geel Robin M. J. M. , Croes Sander 
Published: October 2023

AbstractOsimertinib is prescribed to patients with metastatic non‐small cell lung cancer (NSCLC) and a sensitizing EGFR mutation. Limited data exists on the impact of patient characteristics or osimertinib exposure on effectiveness outcomes. This was a Dutch, multicenter cohort study. Eligible patients were ≥18 years, with metastatic EGFRm+ NSCLC, receiving osimertinib. Primary endpoint was progression‐free survival (PFS). Secondary endpoints included overall survival (OS) and safety. Kaplan‐Meier analyses and multivariate Cox proportional hazard models were performed. In total, 294 patients were included. Primary EGFR‐mutations were mainly exon 19 deletions (54%) and p.L858R point mutations (30%). Osimertinib was given in first‐line (40%), second‐line (46%) or beyond (14%), with median PFS 14.4 (95% CI: 9.4‐19.3), 13.9 (95% CI: 11.3‐16.1) and 8.7 months (95% CI: 4.6‐12.7), respectively. Patients with low BMI (<20.0 kg/m2) had significantly shorter PFS/OS compared to all other subgroups. Patients with a high plasma trough concentration in steady state (Cmin,SS; >271 ng/mL) had shorter PFS compared to a low Cmin,SS (<163 ng/mL; aHR 2.29; 95% CI: 1.13‐4.63). A significant longer PFS was seen in females (aHR = 0.61, 95% CI: 0.45‐0.82) and patients with the exon 19 deletion (aHR = 0.58, 95% CI: 0.36‐0.92). A trend towards longer PFS was seen for TP53 wild‐type patients, while age did not impact PFS. Patients with a primary EGFR exon 19 deletion had longer PFS, while a low BMI, male sex and a high Cmin,SS were indicative for shorter PFS and/or OS. Age was not associated with effectiveness outcomes of osimertinib.
Association of aflatoxin with gallbladder cancer in a case‐control study nested within a Chinese cohort
Authors: Koshiol Jill , Zhu Bin , Wang Renwei , Hildesheim Allan , Gao Yu‐Tang , Egner Patricia A. , Yuan Jian‐Min , Groopman John D. 
Published: October 2023

AbstractWe evaluated whether aflatoxin B1 (AFB1) exposure was associated with later risk of developing gallbladder cancer (GBC). We measured AFB1‐lysine albumin adducts in baseline samples from the Shanghai Cohort Study of 18 244 men aged 45 to 64 years (recruited 1986‐1989). We included 84 GBC cases with sufficient serum and 168 controls matched on age at sample collection, date of blood draw and residence. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for detectable vs non‐detectable AFB1‐lysine albumin adducts and gallbladder cancer. AFB1‐lysine albumin adducts were detected in 50.0% of GBC cases, and risk of GBC was twice as high in those with detectable vs undetectable levels (OR = 2.0, 95% CI = 1.0‐3.9). ORs ranged from 1.8 (95% CI = 0.75‐4.3) for 0.5 to <1.75 pg/mg vs undetectable adduct levels to 2.2 (95% CI = 0.91‐5.6) for >3.36 pg/mg vs undetectable, suggesting a dose‐response (Ptrend = .05). When restricted to cases diagnosed before the median time to diagnosis after blood draw (18.4 years), results were similar (OR = 2.2, 95% CI = 0.80‐5.8) to those for the entire follow‐up duration. The OR was 9.4 (95% CI = 1.7‐51.1) for individuals with detectable AFB1‐lysine albumin adducts and self‐reported gallstones compared to individuals with neither. Participants with detectable AFB1‐lysine albumin adducts at baseline had increased risk of developing GBC, replicating the previously observed association between AFB1 exposure and providing the first evidence of temporality.
Assessment of the Effects of Ciprofloxacin and Nalidixic Acid on Cerebral Blood Flow and Metabolism in Healthy Subjects by Positron Emission Tomography
Authors: Bednarczyk Edward M. , Adler Lee E , Remler Bernd , Goyer Peter , Wiznitzer Max , Leisure Gregory P. , Little Dana , Miraldi Floro 
Published: October 2023

Study Objectives. The mechanism by which the fluorinated quinolones produce central nervous system effects is unknown. Using positron emission tomography (PET), we evaluated the effects of two quinolones on brain blood flow as well as on oxygen and glucose metabolism. These determinations were done in conjunction with ophthalmologic and neuro‐ophthalmologic testing.Design. Randomized, double‐blind, placebo‐controlled, 7‐day course of ciprofloxacin 750 mg (C750) or 500 mg (C500) every 12 hours, or nalidixic acid (NA) 1 g every 6 hours.Population. Twenty‐four healthy male volunteers, six in each treatment arm.Results.Conclusions. Compared with baseline values, NA significantly reduced brain glucose uptake, whereas C500, C750, and placebo produced no detectable effect. No compound significantly altered brain blood flow or oxygen metabolism compared with baseline or other treatments. No significant effect on electroretinographic, electro‐oculographic, or other neuro‐ophthalmologic tests was observed.
Albuterol Delivery by Metered‐Dose Inhaler With a Pediatric Mechanical Ventilatory Circuit Model
Authors: Garner Sandra S. , Wiest Donald B. , Bradley J. Warren 
Published: October 2023

Study Objective. To determine albuterol delivery by metered‐dose inhaler (MDI) in an in vitro pediatric mechanical ventilatory circuit model. The influence of a spacing device, endotracheal tube (ETT) diameter and length, and air humidity was also investigated.Design. An albuterol MDI canister was connected to an AeroVent spacer or Airlife MDI adapter and ETT 4.0, 5.0, or 6.0 mm at commercially available and equal lengths. The ETT tip was attached to an in‐line filter holder with a 1‐μm type A/E glass fiber filter. Ventilator settings were fractional concentration of inspired oxygen 50%, tidal volume 250 ml, inspiratory:expiratory (I:E) ratio 1:3, rate 25 breaths/minute, temperature 35°C, and a decelerating flow pattern. Ten albuterol canisters were activated two times each (total 2000 μg) into dry (4.0‐, 5.0‐, and 6.0‐mm ETT) and humidified air (4.0‐ and 6.0‐mm ETT) and repeated in triplicate. Percentage MDI output was determined by weighing the filter before and after drug administration (balance sensitivity 10 μg). Significant differences (p≤0.05) among the groups with and without a spacer and in dry and humidified air were determined by ANOVA with Scheffe's multiple comparison test. Multiple regression was used to determine significant associations between ETT diameter and length and delivery.Main Results. With the AeroVent spacer in humidified air, delivery with the 4.0‐ and 6.0‐mm ETT was approximately 2.3% and 5%, respectively. The spacer and dry air significantly improved delivery.Conclusions. In humidified air, the dose of albuterol by MDI with an AeroVent spacer should be doubled for children intubated with 6.0‐mm ETT, and four puffs administered for every one puff desired for 4.0‐mm ETT. The results of this investigation should prove useful in initial clinical trials of albuterol MDI in ventilator‐dependent infants and children.
Pharmacokinetics and Pharmacodynamics of Glipizide After Once‐Daily and Divided Doses
Authors: Kradjan Wayne A. , Takeuchi Kathy Y. , Opheim Kent E. , Wood Francis C. 
Published: October 2023

Study Objective. To determine the pharmacokinetics and pharmacodynamics of glipizide given as a single, oral, 20‐mg dose, versus three different divided‐dose regimens totaling 20 mg each.Design. Randomized (in order of dosing regimens), open‐label, crossover study.Setting. University medical center clinical research center.Patients. Six subjects with noninsulin‐dependent diabetes mellitus.Interventions. Patients were studied on four separate occasions separated by at least 3 days. The divided‐dose regimens were designed to simulate delayed absorption of the drug over 2, 4, and 8 hours. Blood samples for measuring glipizide, glucose, and C‐peptide were obtained over 24 hours.Measurements and Main Results. Glipizide peak concentrations and time to peak differed significantly with the dosage schedule; when smaller doses were administered more often, peak concentrations were lower and more delayed. The mean values for area under the curve from time zero to infinity (range 7240.7–10,001.8 μg·L‐1·hr−1; 16,226‐22,414 nmol·L−1·hr−1), clearance (0.44‐0.64 ml·min−1·kg−1; 0.07‐0.11 ml·sec−1·kg−1), post‐distribution phase volume (0.17‐0.25 L·kg−1), and half‐life (4.2–5.4 hrs) were not significantly different among regimens. Neither morning fasting glucose nor maximum and minimum times and concentrations of glucose and C‐peptide over 24 hours were statistically different among regimens. Similarly, no significant differences were found in area under the concentration‐time curve for glucose and C‐peptide measured over 2.5 hours after each meal and from time zero to 24 hours.Conclusions. The timing of a glipizide dose in relation to a meal and simulated delayed or prolonged absorption appear to have little influence on the drug's pharmacodynamic effects.
Piperacillin‐Tazobactam Pharmacokinetics in Patients With Intraabdominal Infections
Authors: Jhee Stanford S. , Kern Jack W. , Burm Jin‐Pil , Yellin Albert E. , Gill Mark A. 
Published: October 2023

Study Objective. To determine the appropriate compartmental and noncompartmental pharmacokinetic parameters for intravenous piperacillin and tazobactam.Design. Sequential selection of patients entered into a randomized, open‐label clinical efficacy trial.Setting. Los Angeles County‐University of Southern California Medical Center.Participants. Sequential sample of 18 patients admitted for intraabdominal infections and consented into a comparative antibiotic trial.Interventions. Patients received piperacillin 4 g plus tazobactam 500 mg by intravenous intermittent infusion every 8 hours.Measurements and Main Results. The estimated noncompartmental pharmacokinetic parameters (mean ± SD) for piperacillin and tazobactam, respectively, were as follows: maximum concentration in plasma 218.7 ± 48.9 μg/ml and 27.8 ± 9.1 μg/ml; half‐life 1.07 ± 0.22 hours and 1.00 ± 0.27 hours; elimination rate constant 0.67 ± 0.13 hr−1 and 0.73 ± 0.18 hr−1; area under the concentration‐time curve from zero hour to infinity 288.5 ± 71.25 mg·hr/L and 36.3 ± 9.55 mg·hr/L; total plasma clearance 14.75 ± 3.93 L/hour and 14.78 ± 4.39 L/hour; renal clearance 5.69 ± 1.94 L/hour and 7.85 ± 3.37 L/hour; volume of distribution at steady state 21.00 ± 4.18 L and 22.47 ± 8.27 L; and mean residence time 1.72 ± 0.29 hours and 1.79 ± 0.35 hours.Conclusion. Our findings were similar to those in other surgical patient models. The two‐compartmental model best described piperacillin and tazobactam disposition in our patients. Bayesian analyses of the two‐compartment models of piperacillin and tazobactam were able to predict trough, peak, and 2‐hour postadministration levels without bias.