bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in organ‐on‐a‐chip for the treatment of cardiovascular diseases
Authors: Liu Jing , Wang Ying 
Published: November 2023

AbstractCardiovascular disease (CVD) is currently a serious and growing public health problem. In tackling this challenge, organ‐on‐chip (OoC) technology, combined with cell culture and microfluidics, presents a powerful approach for constructing sophisticated tissue models in vitro that can simulate the physiological and pathological microenvironments of human organs. Nowadays, OoC technology has emerged as a pivotal tool in advancing our understanding of CVD pathogenesis, facilitating tissue regeneration studies, conducting efficient drug screening, and assessing therapeutic effects. Moreover, it offers a diverse array of study platforms for preclinical research, fostering innovative approaches towards combating CVD and improving patient outcomes. In this review, we first present the key advantages of OoC technology, including its highly relevant physiological microenvironment, incorporation of integrated functions, and the possibility of the construction of multiorgan‐on‐a‐chip through microfluidic linkage. Then, we summarized the role of OoC in the construction of disease pathological models, which provides a new channel for the exploration of disease pathological mechanisms. Moreover, we discuss the application of this technology in cardiac regeneration and drug screening. Finally, we discuss the challenges of tissue models constructed based on OoC technology and the prospects of this innovative approach.
Clinical report and genetic analysis of a Chinese patient with developmental and epileptic encephalopathy associated with novel biallelic variants in the ST3GAL3 gene
Authors: Hu Jihong , Liu Juan , Guo Chunguang , Duan Yaqin , Liu Chunlei , Tan Yaqiong , Pan Ying 
Published: November 2023

AbstractBackgroundDefects in the Golgi enzyme beta‐galactoside‐alpha‐2,3‐sialyltransferase‐III (ST3Gal‐III) caused by biallelic ST3GAL3 gene variants are associated with human neurodevelopmental disorders. Although ST3GAL3 gene variants have been linked to developmental and/or epileptic encephalopathy 15 (DEE15), their presence has only been reported in nine patients; however, the real frequency may be masked by insufficient screening.MethodsPhenotypic information was collected from a male patient with severe psychomotor developmental delay and epileptic seizures, and genetic testing was done using whole exome sequencing. A molecular dynamics simulation analysis was performed to assess the potential impacts of the identified ST3GAL3 variants on the ST3Gal‐III protein function, and a literature review was conducted to compare this case with previously described cases and assess disease manifestation and genetic characteristics.ResultsThe patient inherited compound heterozygous ST3GAL3 gene variants, NM_006279.5:c.809G>A (p.Arg270Gln) and c.921dupG (p.Thr308fs*8). Neither variant had been previously reported in the general population. The p.Arg270Gln variant disrupted a hydrogen bond in the simulated ST3Gal‐III protein structure. Among 25 patients with ST3GAL3 gene defects, eight ST3GAL3 gene variants were identified, and five variants had DEE signs.ConclusionPatients with DEE15 may have novel ST3GAL3 gene variants, and this study may be the first clinical report of their occurrence in a Chinese patient. These variants should be considered when evaluating patients presenting with unexplained early‐onset epileptic encephalopathy, severe developmental delay, and/or intellectual disability.
A chimeric medial femoral condyle chondro‐osseus flap with two thin periosteal flaps to reconstruct partial necrosis of talar body: A case report
Authors: Alice Letizia Andreoli , Sara Tamburello , Stefano Bianco , Mori Francesco , Giulio Menichini 
Published: November 2023

AbstractTotal talar extrusion is a rare complication of high‐energy traumas. A consequence of this injury can be avascular necrosis (AVN) of the talus. Patients are confronted with pain, limited range of motion and post‐traumatic arthritis. As AVN progresses the talus is gradually destroyed. This report presents the use of a chimeric medial femoral condyle chondro‐osseus flap with two thin periosteal flaps to increase vascular supply to the traumatized area, accelerate bone formation, flap integration, and restore articular surfaces in a patient with partial necrosis of talar body. The patient was a 26‐year‐old female with open left lateral talar extrusion after a motor‐vehicle accident that developed a partial avascular necrosis, at the level of the subtalar and ankle joint with altered talar dome surface with partial depression of 2 cm. The patient was in pain and not able to walk. The medial femoral condyle chondro‐osseus portion was placed in the talar dome depression to restore the subtalar joint, the periosteal flaps were placed on top to reconstruct the ankle joint restoring the articular surfaces and the correct weight‐bearing distribution. No complications or morbidity of donor site were observed. One year after the operation, the patient walks free, without pain. Post‐operatory x‐ray performed, evidenced progressive bone healing and reduction of the AVN. In the intent of performing a joint‐saving procedure, the presented chimeric flap might be effective in the short‐term with excellent clinical and radiographic outcomes.
Which parameters, related to the female urethra and pelvic floor, determine therapy selection for recurrent female stress urinary incontinence: ICI‐RS 2023?
Authors: Ockrim Jeremy , Kearney Rohna , Carolina Ochoa D. , Hashim Hashim , Van Koeveringe Gommert , Chermansky Christopher , Cardozo Linda , Wein Alan , Abrams Paul 
Published: November 2023

AbstractIntroductionThe evidence basis for therapy selection in women who have failed primary stress urinary incontinence (SUI) surgery is limited. The ICI‐RS group discussed the available data at its meeting in June 2023, particularly the anatomical characteristics as assessed using magnetic resonance imaging (MRI) and ultrasound (US) modalities, functional characteristics associated with storage and voiding urodynamic assessment, as well as the patient characteristics that might influence outcomes. This paper summarizes the evidence base that supported these discussions and offers the basis for research proposals for future groups.MethodsA literature search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed, and the data is presented. Research questions are based on the knowledge gaps highlighted.ResultsPossible MRI parameters that may influence outcomes were striated urethral sphincter volume, bladder and proximal urethral funneling, pubo‐urethral ligament integrity, distance of the bladder neck below the pubococcygeal line, posterior urethra‐vesical angle, and bladder neck to levator ani distance. US parameters included sling distance to the urethral lumen and pubis, sling position, bladder neck mobility, and lateral arm asymmetry, twisting, or curling. Urodynamic parameters included detrusor overactivity, Valsalva leak point pressure, maximum urethral closure pressure, and bladder outlet obstruction. Important patient parameters included body mass index, age, and previous interventions.ConclusionsIdentifying and quantifying causative factors in patients with recurrent SUI, that allow clinicians to modify subsequent treatment choices and techniques may help reduce treatment failure and complications. Formulating algorithms is the next step in optimizing patient counseling, surgical selection, and healthcare allocation.
High Prevalence of Obstructive Sleep‐Disordered Breathing in Pediatric Patients With Turner Syndrome
Authors: Pham Tiffany T. , Davis Shanlee M. , Tong Suhong , Campa Khaled A. , Friedman Norman R. , Gitomer Sarah A. 
Published: November 2023

AbstractObjectiveGirls with Turner syndrome (TS) often have features that have been associated with obstructive sleep‐disordered breathing (oSDB). However, little is known about oSDB in TS. Herein, we aimed to characterize oSDB in young patients with TS and identify associated risk factors.Study DesignRetrospective cross‐sectional study.SettingTertiary care pediatric hospital.MethodsWe reviewed medical records for patients diagnosed with TS seen at our institution between October 1, 2007 and December 31, 2019 with the first outpatient visit before age 6 years. The prevalence of oSDB was compared to the general pediatric population with 1‐sample binomial proportion tests. Clinical characteristics were compared between those diagnosed with oSDB and those without oSDB, and risk factors for oSDB were identified.ResultsOf 151 patients with TS, 73 (48%) were diagnosed with oSDB which is 4‐fold higher than the general pediatric population (12%, P < 0.0001). In the multivariable model, adenoid, tonsillar, and inferior turbinate hypertrophy, birthweight, failure to thrive, and older age at the last clinic visit were all associated with increased odds for oSDB.ConclusionYoung children with TS have a high prevalence of oSDB and thus should be screened for oSDB. Polysomnography should be performed in those with associated risk factors and symptoms oSDB. Treatment of oSDB is imperative as individuals with TS are already at increased risk of behavioral problems, neurocognitive deficits, and growth impairment that may be worsened with oSDB.
Personalizing homelessness prevention: Evidence from a randomized controlled trial
Authors: Phillips David C. , Sullivan James X. 
Published: November 2023

AbstractThrough a randomized controlled trial, we test whether providing personalized case management alongside emergency financial assistance more effectively prevents homelessness than financial assistance alone. For a sample of young adults and families with children who are at risk of homelessness, our results indicate that participants assigned to case management and financial assistance are more likely to access other homeless programs and no less likely to be evicted. Downstream outcomes are mostly unchanged, though arrests increase. Using non‐experimental variation across staff, we find that case management is associated with better outcomes when it is more intensive and pays financial assistance quickly.
Synthesis and characterization of polyfuran/polythiophene oligomers: Oligomer–protein interaction studies
Authors: Farooq Aaliyah , Nabi Nuzhat , Alam Javed , Riaz Ufana 
Published: November 2023

AbstractWater‐soluble polyfuran (PF), polythiophene (PTh), and their co‐oligomers were synthesized and the formation of the oligomers was confirmed by FTIR, UV–visible, and SEM techniques. Bovine serum albumin (BSA) and human serum albumin (HSA) were used to study the biophysical interaction of these oligomers with proteins. Molecular docking studies confirmed that the interaction with HSA was higher than that for BSA and was found be via hydrogen bonding and π‐alkyl interaction. The co‐oligomers showed high binding affinity toward HSA as compared to BSA which could be utilized for developing protein sensors.
Balancing anticoagulation and hemostasis in an infant with severe hemophilia A during cardiac transplantation: Review of the literature and development of a surgical protocol
Authors: Regling Katherine , Sehgal Swati , Hollon Wendy , Rayner Patricia , Stricker Lori , Sarnaik Ajit , Sassalos Peter , Al‐Ahmadi Mamdouh , Rajpurkar Madhvi , Chitlur Meera B. 
Published: November 2023

AbstractHemophilia A is a disorder resulting in a deficiency of clotting factor VIII that can lead to life‐threatening bleeding. Evidence‐based guidelines for surgical interventions like cardiac surgery are limited. Anticoagulation is necessary for cardiac bypass, thus risk of bleeding in a patient with hemophilia is increased and requires careful attention to maintain hemostasis. We report the first infant with severe hemophilia A and dilated cardiomyopathy who underwent successful cardiac transplantation, and review the literature on previous cardiac transplant cases in congenital hemophilia. To ensure safe and effective management, a multidisciplinary approach was used to develop the surgical protocol for transplant.
Plastic composite of bamboo charcoal stabilized polyethylene glycol with thermal energy storage and temperature regulation for building energy efficiency
Authors: Ji Xianjun , Liu Pengwei , Qiu Chendong , Weng Lu , Hu Jiajun , Wei Renzhong , Zhang Yi , Sun Weisheng , Guo Xi 
Published: November 2023

AbstractPhase change materials (PCMs) are often used as building materials to reduce the energy consumption. However, conventional PCMs are susceptible to leakage and have a short service life. To solve this problem, thermal energy storage (TES) composites were fabricated by using bamboo charcoal (BC) encapsulating polyethylene glycol (PEG) as the PCM and low density polyethylene (LDPE) as the matrix. The shape and structure of BC and BC‐plastic composites were examined using scanning electron microscopy, X‐ray diffractometry, and mercury intrusion porosimetry. Differential scanning calorimetry, thermogravimetry (TG), and infrared thermography were used to characterize the manufactured TES composites. Physical and mechanical strength assessments were also conducted. The results demonstrated that: (1) BC possessed a rich void structure with a porosity of 61.4%, which could be used to adsorb PEG and the composites was a combination of PEG, BC, and LDPE with no chemical reaction; (2) thermal tests demonstrated that the composites exhibited favorable temperature regulation properties, featuring a maximum latent heat capacity of 29.1 J/g along with suitable phase change temperatures, yet thermal durability needs to be improved much further, addition of PEG reduced thermal conductivity of the composite from 0.38 to 0.34 W/mK; (3) the addition of PEG was beneficial for the impact strength but had a negative impact on the flexural and tensile properties; and (4) due to their satisfactory thermal performance and acceptable mechanical properties, these TES composites can be effectively utilized as building materials for temperature control purposes.Highlights
Bamboo charcoal (BC) had a large number of pores that can encapsulate polyethylene glycol (PEG).
PEG/BC performed satisfactory latent heat.
Low density polyethylene was used as the matrix to realize the second encapsulation of phase change material.
Thermal energy storage composites had excellent stability and good heat storage capacity.
PEG incorporation negatively affected flexural and tensile properties.
Impact of silanization on the characterization of Corchorus olitorius particle‐based composites for sustainable applications
Authors: Mahakur Vijay Kumar , Bhowmik Sumit , Patowari Promod Kumar 
Published: November 2023

AbstractResearchers are actively working on developing a long‐term substitute for harmful manmade fibres. Because of their unique qualities that fit diverse applications, natural fibres/fillers are proposed as sustainable reinforcements. Integrating natural fibres, such as Corchorus olitorius particles, into composites provides an environmentally conscious choice for a variety of purposes. This research aims to investigate the influence of silanization, a surface modification technique, on the various characterizations and characteristics of Corchorus olitorius particle‐based composites. The characterizations included morphological, mechanical and thermal investigations to assess the influence of silanization on the characteristics of the composite. The contact layup process is applied to create composite samples by reinforcing multiple weight proportions of treated particles (2.5%, 5%, 7.5%, 10% and 12.5%) in epoxy resins. The findings demonstrate that silanization elevates the interfacial connectivity between Corchorus olitorius particles and the resins, which produces upgraded mechanical and thermal attributes. The composite containing 5 wt% particles generated the most significant tensile and flexural strength, with gains of about 45% and 31%, respectively, compared to the epoxy composite. Because of the higher interfacial connections of the molecules, the viscoelastic features of the composites indicated that the 7.5 wt% particle‐based composite possesses the greatest storage modulus (2.96 GPa), loss modulus (0.4 GPa) and glass transition temperature (90 °C). This study emphasizes the significance of surface alteration procedures such as silanization for boosting the efficiency and long‐term viability of composites containing Corchorus olitorius particles. © 2023 Society of Industrial Chemistry.
Formation control scheme with reinforcement learning strategy for a group of multiple surface vehicles
Authors: Nguyen Khai , Dang Van Trong , Pham Dinh Duong , Dao Phuong Nam 
Published: November 2023

AbstractThis article presents a comprehensive approach to integrate formation tracking control and optimal control for a fleet of multiple surface vehicles (SVs), accounting for both kinematic and dynamic models of each SV agent. The proposed control framework comprises two core components: a high‐level displacement‐based formation controller and a low‐level reinforcement learning (RL)‐based optimal control strategy for individual SV agents. The high‐level formation control law, employing a modified gradient method, is introduced to guide the SVs in achieving desired formations. Meanwhile, the low‐level control structure, featuring time‐varying references, incorporates the RL algorithm by transforming the time‐varying closed agent system into an equivalent autonomous system. The application of Lyapunov's direct approach, along with the existence of the Bellman function, guarantees the stability and optimality of the proposed design. Through extensive numerical simulations, encompassing various comparisons and scenarios, this study demonstrates the efficacy of the novel formation control strategy for multiple SV agent systems, showcasing its potential for real‐world applications.
Counting orientations of random graphs with no directed k‐cycles
Authors: Campos Marcelo , Collares Maurício , Mota Guilherme Oliveira 
Published: November 2023

AbstractFor every , we determine the order of growth, up to polylogarithmic factors, of the number of orientations of the binomial random graph containing no directed cycle of length . This solves a conjecture of Kohayakawa, Morris and the last two authors.
From traditional innovation to green innovation: How an occurrence of natural disasters influences sustainable development?
Authors: Ma Yan , Feng Gen‐Fu , Chang Chun‐Ping 
Published: November 2023

AbstractWith the high incidence of extreme events, it is important to examine how the occurrence of natural disasters influences long‐term sustainable development. We give evidence from the changing process of innovation. Using data from OECD countries from 1985 to 2018, we conclude that environmental threats from the occurrence of natural disasters drive countries to pay more attention to sustainable development and promote the change of innovation type from traditional to green innovation. Moreover, for different types of natural disasters, volcanic activities, landslides, and floods show a positive influence, while epidemics dampen it. Based on the sub‐sample analysis, this impact is more pronounced in countries with high levels of economic development, oil exports and right‐wing parties in power. Furthermore, renewable energy consumption acts as a positive moderator, while the moderating effects of government efficiency, corruption and globalization are inhibiting. Our paper provides new insights into natural disaster economics and sustainable development.
Photocatalytic Performance and Degradation Pathways of Z‐Scheme BiO2−X−Ag3PO4 Photocatalysts with Oxygen‐Deficient Structures
Authors: Han Hui , Jiang Sisi , Zhao Qian , Jiang Tingshun 
Published: November 2023

AbstractIt is a practical way to raise the efficiency of photocatalysis by using oxygen vacancy defect modified materials. In this experiment, a Z‐scheme BOA composite photocatalyst with defect structure was prepared by hydrothermal in situ precipitation method. The optimal ratio of 1.5 BOA showed excellent photocatalytic degradation performance for MO, TC and CIP under visible light irradiation, and maintained good structural stability and circulation rate after five cycles. The increased photocatalytic activity of the composite can be explained to the heterojunction interface‘s synergistic effects and the quicker electron hole transit rate caused by the surface oxygen vacancy defect. XPS and EPR confirmed the existence of anoxic structure in the composite, PL and photocurrent confirmed the high electron hole transfer rate. The active species that contributed to the degradation process were validated by the active species capture experiment and ESR. LC–MS speculated the possible degradation path of CIP. Finally speculated the reaction mechanism of Z‐scheme BOA composite photocatalyst. Using the anoxic structure of BiO2−X to form a Z‐scheme heterostructure with Ag3PO4, the oxygen vacancy as the electron capture center and active site is conducive to improving the photogenerated electron transfer rate, thereby improving the structural stability and photocatalytic performance of the complex.
Utilization of Interfacial Films of Organo‐Modified Carbon Nanotubes as Adsorption Templates for a Number of Biomolecules while Maintaining their Activity
Authors: Yamada Yuna , Xu Kai , Fujimori Atsuhiro 
Published: November 2023

AbstractWe investigated the versatility of a monolayer of organo‐modified single‐walled carbon nanotubes (SWCNTs) on a water surface as a template to maintain activity by adsorbing various biomolecules from the subphase. Organo‐modified SWCNTs with amphiphilic properties formed a Langmuir film on the subphase containing biomolecules, and adsorbed and immobilized biomolecules via electrostatic interactions. In this study, the interactions of trypsin, lysozyme, cytochrome C protein, glucose oxidase sugar chain polymer, deoxyribonucleic acid, and chitosan with SWCNTs at the air/water interface were investigated. The uniqueness of this study is that it shows the possibility of wide‐ranging applications by utilizing an organo‐modified SWCNT interfacial film as an adsorption template for various biomolecules. The expansion behavior of the surface pressure‐area isotherms indicated the existence of interactions between the organo‐modified SWCNTs monolayer on the water surface and the biomolecules. The morphology and spectroscopic properties of the films transferred onto solid substrates clearly indicate the adsorption and immobilization of biomolecular groups. DNA and chitosan were not immobilized on the organo‐modified SWCNTs film template; however, the other four enzyme/protein molecules were adsorbed onto the solid substrate and maintained their fine second‐order structures, even under harsh conditions.
Investigation of Antimicrobial, Cytotoxic, and Larvicidal Activities of Favipiravir
Authors: Aydın Hasan , Uslu Uğur , Akocak Süleyman , Lolak Nebih , Sait Ahmet , Korkmaz Serol , Parmaksız Ayşe , Ceylan Onur , Aksakal Abdulbaki 
Published: November 2023

AbstractGrowing number of deaths due to decreased effects of antibiotics has increased the need for new antimicrobial drugs. Studies on the pharmacological effect and toxicity of favipiravir, a new antiviral drug that was informally recommended by World Health Organization (WHO) for the treatment of Coronavirus Disease 2019 (COVID‐19) for a while, are limited and still ongoing. We first aimed to evaluate the antibacterial efficacy of favipiravir in silico. A second aim of the manuscript is to examine its antibacterial, antifungal, cytotoxic, antiviral and larvicidal effects in vitro. In this study, it was determined that favipiravir was effective in terms of in silico antibacterial, in vitro antibacterial, antifungal, cytotoxicity, antiviral and larvicidal activities. As a result, potential areas of use can be found in terms of activities under investigation.