bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colchicine disrupts bile acid metabolic homeostasis by affecting the enterohepatic circulation in mice
Authors: Shi Yongpeng , Wei Li , Jin Fang , Wang Ji , Cao Hanwen , Yang Ying , Gao Lan 
Published: February 2024

AbstractAlthough the medicinal properties of colchicine (COL) have been widely known for centuries, its toxicity has been the subject of controversy. The narrow therapeutic window causes COL to induce gastrointestinal adverse effects even when taken at recommended doses, mainly manifested as nausea, vomiting, and diarrhea. However, the mechanism of COL‐induced gastrointestinal toxic reactions remains obscure. In the present study, the mice were dosed with COL (2.5 mg/kg b.w./day) for a week to explore the effect of COL on bile acid metabolism and the mechanism of COL‐induced diarrhea. The results showed that COL treatment affected liver biochemistry in mice, resulting in a significant down‐regulation of the mRNA expression levels of bile acid biosynthesis regulators Cyp7a1, Cyp8b1, Cyp7b1, and Cyp27a1 in liver tissues. The mRNA expression levels of bile acid transporters Ntcp, Oatp1, Mrp2, Ibabp, Mrp3, Osta, and Ostb in liver and ileum tissues were also significantly down‐regulated. In addition, COL treatment significantly inhibited the mRNA expression levels of Fxr and its downstream target genes Shp, Lrh1, and Fgf15 in liver and ileum tissues, affecting the feedback regulation of bile acid biosynthesis. More importantly, the inhibition of COL on bile acid transporters in ileal and hepatic tissues affected bile acid recycling in the ileum as well as their reuptake in the liver, leading to a significantly increased accumulation of bile acids in the colon, which may be an important cause of diarrhea. In conclusion, our study revealed that COL treatment affected bile acid biosynthesis and enterohepatic circulation, thereby disrupting bile acid metabolic homeostasis in mice.
Mass spectrometric study of low energy Cs+ ion‐induced sputtered fragmentation of PADC polymer
Authors: Abbas Muhammad Sabbtain , Jehanzaib Bilal , Hussain Shahzad , Mahmood Abid , Ahmad Riaz 
Published: February 2024

AbstractIn this study, low‐energy cesium (Cs+) ion‐induced sputtered fragmentation of poly allyl diglycol carbonate (PADC) was investigated using mass spectrometry. The collision‐induced dissociation mechanism revealed emission of various fragments, including monoatomic (H−, C1−, O1−), diatomic (C2−), and multiatomic (C3−, CO2−, C2O2−, C3O2−) species within the Cs+ ion energy range of 1–5 keV. The anion current of these fragments exhibited a linear increase with rising incident Cs+ ion energy, indicating a corresponding rise in fragment abundance. Analysis of normalized yield indicated that at 1 keV incident energy, the dominant fragment was monoatomic hydrogen (H−), followed by diatomic carbon (C2−), monoatomic carbon (C1−), and monoatomic oxygen (O1−). Although C2− remained dominant up to 5 keV, other fragments exhibited varying normalized yields at different ion energy steps. The sputter yield estimation revealed that monoatomic hydrogen (H−) and diatomic carbon (C2−) exhibited the highest yields, increasing exponentially beyond 3 keV, while multiatomic fragments like C3−, CO2−, C2O2−, and C3O2− displayed the lowest yields. The sputter dissociation mechanism pointed to dehydrogenation, chain scission, and bond breakage as the primary processes during low‐energy Cs+ ion impact. Postsputtering Scanning Electron Mircoscope (SEM) micrographs show craters, pits, and micropores on the PADC surface, indicating significant surface degradation. X‐ray Diffraction (XRD) spectra exhibited reduced diffraction intensity, while Fourier Transform Infrared Spectroscopy (FTIR) analysis indicated the absence of molecular bands in the IR spectrum, confirming extensive surface damage due to Cs+ ion‐induced sputtering.
What a difference a chlorine makes: The remarkable unimolecular ion chemistry of phenyl formate and phenyl chloroformate
Authors: Lowe Bethany , Cardona Alejandro L. , Salas Juana , Bodi Andras , Mayer Paul M. , Burgos Paci Maxi A. 
Published: February 2024

AbstractImaging photoelectron photoion coincidence (iPEPICO) spectroscopy and tandem mass spectrometry were employed to explore the ionisation and dissociative ionisation of phenyl formate (PF) and phenyl chloroformate (PCF). The threshold photoelectron spectra of both compounds are featureless and lack a definitive origin transition, owing to the internal rotation of the formate functional group relative to the benzene ring, active upon ionisation. CBS‐QB3 calculations yield ionisation energies of 8.88 and 9.03 eV for PF and PCF, respectively. Ionised PF dissociates by the loss of CO via a transition state composed of a phenoxy cation and HCO moieties. The dissociation of PCF ions involves the competing losses of CO (m/z 128/130), Cl (m/z 121) and CO2 (m/z 112/114), with Cl loss also shown to occur from the second excited state in a non‐statistical process. The primary CO‐ and Cl‐loss fragment ions undergo sequential reactions leading to fragment ions at m/z 98 and 77. The mass‐analysed ion kinetic energy (MIKE) spectrum of PCF+ showed that the loss of CO2 occurs with a large reverse energy barrier, which is consistent with the computationally derived minimum energy reaction pathway.
Linking weather conditions and winter tick abundance in moose
Authors: Pouchet Catherine , Fernandez‐Prada Christopher , Dussault Christian , Leclerc Martin , Tremblay Jean‐Pierre , Côté Steeve D. 
Published: February 2024

AbstractClimate change may modify species distribution to higher latitudes, resulting in potential changes of parasite diversity and transmission dynamics in areas where animals might not be locally adapted to these new parasite species. In addition, climate change may increase the frequency and severity of infestations of parasites that are already present in a region, by promoting the development and survival of infectious stages. Over the last decades, the number of moose (Alces americanus) infested by winter ticks (Dermacentor albipictus) has increased in eastern Canada, possibly because milder climatic conditions are increasing winter tick survival. Our main objective was to determine which meteorological variables are more likely to influence winter tick load on moose. We compiled several weather variables that may limit winter tick survival and explored which weather variables, or their interactions, influenced the winter tick load of 4,100 hunted moose from 2013 to 2019 in Québec, Canada along a latitudinal gradient. Winter tick load in fall decreased with the maximum number of consecutive days in spring with average daily temperatures below −15°C and with the number of consecutive days in summer with a relative humidity <80% when snowmelt in spring was earlier. These results suggest that cold temperatures and prolonged periods of low humidity, amplified by early snowmelt, limit the survival of adult female ticks and eggs, thus limiting their subsequent load on moose during the following fall. With climate change, precipitation increases and warm temperatures occur earlier in spring and are more frequent in summer. Our results suggest that climate change may have a positive long‐term influence on winter tick abundance in the environment and thereby increase winter tick load on moose, which could lead to a significant decrease in moose body condition and survival.
Hepatocellular carcinoma: signaling pathways, targeted therapy, and immunotherapy
Authors: Luo Xiaoting , He Xin , Zhang Xingmei , Zhao Xiaohui , Zhang Yuzhe , Shi Yusheng , Hua Shengni 
Published: February 2024

AbstractHepatocellular carcinoma (HCC) is the most common primary liver cancer with a high mortality rate. It is regarded as a significant public health issue because of its complicated pathophysiology, high metastasis, and recurrence rates. There are no obvious symptoms in the early stage of HCC, which often leads to delays in diagnosis. Traditional treatment methods such as surgical resection, radiotherapy, chemotherapy, and interventional therapies have limited therapeutic effects for HCC patients with recurrence or metastasis. With the development of molecular biology and immunology, molecular signaling pathways and immune checkpoint were identified as the main mechanism of HCC progression. Targeting these molecules has become a new direction for the treatment of HCC. At present, the combination of targeted drugs and immune checkpoint inhibitors is the first choice for advanced HCC patients. In this review, we mainly focus on the cutting‐edge research of signaling pathways and corresponding targeted therapy and immunotherapy in HCC. It is of great significance to comprehensively understand the pathogenesis of HCC, search for potential therapeutic targets, and optimize the treatment strategies of HCC.
Hexahedral finite elements with enhanced fixed‐pole interpolation for linear static and vibration analysis of 3D micropolar continuum
Authors: Grbac Laura , Jelenic Gordan , Ribarić Dragan , Erdelj Sara Grbčić 
Published: February 2024

AbstractThe spotlight of this research is on the application of the fixed‐pole interpolation, sometimes used in the analysis of three‐dimensional (3D) geometrically non‐linear beams, but for which no attempts have been made to apply it to linear analysis so far. Particular attention is given to the correlation between the linearised forms of the fixed‐pole and helicoidal interpolation with the linked interpolation. Knowledge of this interdependence is crucial for identifying paths for possible enhancement and extension from the Timoshenko beam of arbitrary order to the new hexahedral finite element of arbitrary order for linear analysis of 3D micropolar continuum. After ensuring the convergence of the newly developed micropolar element through a set of patch tests, three numerical examples of a 3D micropolar continuum in static equilibrium and free vibration of 3D micropolar plates with different geometric properties and boundary conditions have been analysed. Based on these results, the newly proposed finite elements have been critically assessed against the conventional elements.
Biotechnological interventions for monitoring and mitigating microplastic pollution and development of alternatives to single‐use plastics
Authors: Shanmugam Mahadevan Indumathi , Harsha Vardhan Madurai Kathiravan , Rejith Kumar Rajkumar Sheeja , Rohinth Mourougavel , Tawfeeq Ahmed Zakir Hussain , Prakash Pandurangan , Kumar Jagadeesan Aravind 
Published: February 2024

AbstractThe dawn of mass plastic production in the early 20th century has accelerated the penetration of microplastics into the environment, making them known to be an insidious threat to diverse ecosystems. The current scenario for microplastics is dire, as they pervade living organisms and disrupt vital functions while also affecting the environment by altering soil quality. They pose an inherent risk to human health, making their elimination a multifaceted challenge. Due to factors such as small size, low biodegradability, and ubiquity, microplastics are particularly challenging to detect, and methods for their elimination from terrestrial and marine environments are an ever‐evolving field of research. The detection of such microplastics has necessitated the use of various biotechnological techniques to monitor microplastic pollution. The control of microplastic pollution in natural ecosystems can be met by replacing mass‐produced single‐use plastics with viable bio‐based alternatives. The main objectives of this review are to discuss how microplastic pollution is currently monitored, assessed, and controlled using satellite‐generated imagery complemented with a range of biotechnological and bioremedial techniques. This review also traces the development of a range of bio‐based plastic alternatives that are observed to potentially replace single‐use plastics. Further discussion on the various challenges and prospects for the mitigation of microplastics will also be conducted, stressing the importance of future research.
Techno-economics Analysis on Sodium-Ion Batteries: Overview and Prospective
Authors: Ferraro Marco , Tumminia Giovanni 
Published: February 2024

AbstractSodium-ion batteries are considered compelling electrochemical energy storage systems considering its abundant resources, high cost-effectiveness, and high safety. Therefore, sodium-ion batteries might become an economically promising alternative to lithium-ion batteries (LIBs). However, while there are several works available in the literature on the costs of lithium-ion battery materials, cells, and modules, there is relatively little available analysis of these for sodium ion. Moreover, most of the works on sodium ion focus on costs of material preparation and the electrodes/electrolytes taken in isolation, without considering the costs of the whole cell or battery system. Therefore, the lack of a cost analysis makes it hard to evaluate the long-term feasibility of this storage technology. In this context, this focus chapter presents a preliminary techno-economics analysis on sodium-ion batteries, based on the review of the recent literature. The main materials/components contributing to the price of the sodium-ion batteries are investigated, along with core challenges presently limiting their development and benefits of their practical deployment. The results are also compared with those of competing lithium-ion technology.
Social Implications
Authors: Pechancová Viera , Sáha Petr , Pavelková Drahomíra 
Published: February 2024

AbstractThe book chapter addresses the vulnerabilities and sustainability challenges in the battery industry, emphasising the importance of social acceptance in the context of a variety of applications. The battery industry’s environmental impacts, supply chain issues and geopolitical concerns are discussed, along with the need for just energy transitions and human rights safeguards. The role of batteries in energy storage, e-mobility and grid storage is explored, including the phenomenon of range anxiety in electric vehicles. The chapter underscores the significance of combining technical advancements with social factors for successful energy technology transitions and achieving sustainable battery value chain. Social innovation and acceptance issues related to battery technologies are highlighted, considering factors like socio-political, market and community acceptance. Overall, the text advocates for a balanced approach between societal needs, environmental conservation and technological advancements in the battery industry.
Principles of a Circular Economy for Batteries
Authors: Helbig Christoph , Hillenbrand Martin 
Published: February 2024

AbstractThe global market for batteries is rapidly growing, leading to significant material requirements to build up an in-use stock of batteries for mobility and stationary applications. One strategy to secure the material supply for batteries and simultaneously reduce the life cycle environmental impacts of batteries is the implementation of a circular economy for batteries, chiefly lithium-ion battery materials. In a circular economy, material cycles are narrowed, slowed, and closed to form cyclical or cascading material flows instead of linear take-make-waste schemes. The most common measures to implement a circular economy are so-called R-imperatives: refuse, rethink, reduce, reuse, repair, remanufacture, refurbish, repurpose, recycle, and recover. By implementing these R-imperatives, batteries can be designed to provide the highest functional value with the lowest material requirements. Their life is prolonged by repair and remanufacturing activities, and the valuable materials can be recycled through various processes. Legislative initiatives like the EU Battery Regulation and technological development foster the implementation of such a circular economy for batteries.
Overview of Energy Storage Technologies Besides Batteries
Authors: Schischke Eva , Grevé Anna , Ehrenstein Ulrike , Doetsch Christian 
Published: February 2024

AbstractThis chapter provides an overview of energy storage technologies besides what is commonly referred to as batteries, namely, pumped hydro storage, compressed air energy storage, flywheel storage, flow batteries, and power-to-X technologies. The operating principle of each technology is described briefly along with typical applications of the technology. Additionally, insights into the ecological footprint of the different energy storage systems are presented.
Theoretisches Fazit und Konkretisierung der Forschungsfragen
Authors: Tokarski Bianca Maria 
Published: February 2024

ZusammenfassungFür die Erforschung von Handlungskoordination in der Weiterbildungsplanung und -entwicklung werden aus methodologischer Sicht Zugangswege benötigt, die auf der Individualebene eine strukturierte Erfassung von handlungsleitenden Absichten, Interaktion und Handlungskoordination zwischen Akteur:innen ermöglichen. Wie theoretisch nachvollzogen werden konnte, bietet die Konventionenökonomie hierzu einen potenziell geeigneten Zugang.
Bodmers Miltonübersetzungen*
Authors: Guthrie John 
Published: February 2024

ZusammenfassungBodmer’s translation of Milton’s Paradise Lost was a milestone in translations of English works of literature into German in the eighteenth century. Its importance is often not recognised and it fared badly at the hands of critics. Its qualities were sidelined by discussion of aesthetic and literary issues arising in the dispute between Zurich and Leipzig. This essay asks what attracted Bodmer to Milton, why he undertook the prose translation of Paradise Lost and what the result was. In answer it highlights the power of Milton’s depiction of nature, the connection between nature and the sublime, and Bodmer’s identification with Milton and the characters in Paradise Lost. It analyses reasons for the choice of prose, arguing in contrast to earlier research that the similarities between the different versions of the translation are more significant than the differences. In assessing the pitfalls and the advantages of Bodmer’s translation this essay draws on approaches in translation studies.
Zwischen Historia und Fabula. Maria Stuart als gespenstische Schwellenfigur in Andreas Gryphius’ Carolus Stuardus
Authors: Fischer Conrad 
Published: February 2024

ZusammenfassungThis article seeks to contextualize a comment by the author Gryphius on the appearance of Mary Stuart in his tragedyCarolus Stuardus(1657/1663). To explain her entry, Gryphius lectures on the historical sources from Buchanan to Camden for the portrayal of Mary Stuart as the sufferer of a trial of injustice. In contrast, there is the literary history of reception, which Gryphius doesn’t mention. Here, after her death, for example in Joost van den Vondel's dramaMaria Stuart(1646), Mary Stuart is staged primarily as a Christian Catholic martyr. Gryphius, in turn, according to the central thesis of this article, transforms her Christian martyrdom into a political one by staging Mary as a spirit of the dead. As a dramatic example, Mary thus lends her (ghostly) voice to the historical injustice of the English regicide.
Der Kurtze Wegweiser zur Erlernung der Englischen Sprache und die Gestaltung seiner Musterdialoge
Authors: Doms Misia Sophia 
Published: February 2024

ZusammenfassungFirst published in Hamburg in 1699, the Short guide to learn the Englisch [sic!] Tongue by F. K. forms a prototypical example for the textbooks used by early modern learners of English and other modern languages. At the heart of the textbook we can find a collection of 16 situational dialogues offering communication models for their well-to-do bourgeois readers. Some passages of these dialogues seem to consist of a mere series of incoherent ready-made phrases for everyday conversation with Englishmen during travels abroad or business negotiations, while other more coherent parts have a more immersive and entertaining design. In some cases, their elements seem to have been adopted from comedy. In the Short guide’s fourth edition from 1713 the dialogues clearly refer to the social environment of the knight academies and thus to the galant context of nobility which, at the turn of the 18th century, was especially attractive to the ambitious young members of bourgeoisie supposed to use the textbook.
John Bunyans Pilgrim’s Progress in Wales: Taith neu Siwrnai y Pererin (1688) und Taith y Pererin (1699)
Authors: Poppe Erich 
Published: February 2024

ZusammenfassungMy contribution discusses two translations of John Bunyan’sPilgrim’s Progressinto Welsh,Taith neu Siwrnai y Pererin‘The pilgrim’s progress or journey’ (London, 1688) andTaith y Pererin‘The pilgrim’s progress’ (Shrewsbury, 1699). It begins with a presentation of the translators, their background and interests, and the books themselves. It then concentrates on the earlier text, especially on the introductory letter of the main translator and driving spirit behind the project, Stephen Hughes (1622–1688), in which he remarks on the strategies for translating, on the changes implemented in the Welsh text, and on the marginal paratexts, complemented by some comparisons with the later version. The metrical forms of the Welsh adaptations of the English verses and the Welsh translations of English descriptive names and special terms are considered next. The contribution closes with remarks on the reception of the translation, which shows that it has become part of the Welsh literary canon of the eighteenth and nineteenth centuries. One result of the analysis, instructive for literary and translation studies, is the insight that due to the translators’ interventions the relation between the source and the target texts becomes opaque: readers can never be quite certain whether they read Bunyan or his translators.
A glimpse into novel acylations and their emerging role in regulating cancer metastasis
Authors: Shi Huifang , Cui Weigang , Qin Yan , Chen Lei , Yu Tao , Lv Jie 
Published: February 2024

AbstractMetastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be further elucidated. A large amount of preliminary investigations focus on the role of epigenetic mechanisms in cancer metastasis. Notably, the posttranslational modifications were found to be critically involved in malignancy, thus attracting considerable attention. Beyond acetylation, novel forms of acylation have been recently identified following advances in mass spectrometry, proteomics technologies, and bioinformatics, such as propionylation, butyrylation, malonylation, succinylation, crotonylation, 2-hydroxyisobutyrylation, lactylation, among others. These novel acylations play pivotal roles in regulating different aspects of energy mechanism and mediating signal transduction by covalently modifying histone or nonhistone proteins. Furthermore, these acylations and their modifying enzymes show promise regarding the diagnosis and treatment of tumors, especially tumor metastasis. Here, we comprehensively review the identification and characterization of 11 novel acylations, and the corresponding modifying enzymes, highlighting their significance for tumor metastasis. We also focus on their potential application as clinical therapeutic targets and diagnostic predictors, discussing the current obstacles and future research prospects.