bluuebunny/crossref_metadata_2025_split huggingface dataset:
IDENTIFICATION OF PHYSIOLOGICAL AND PSYCHOLOGICAL CHANGES DURING MENOPAUSE IN BIREUEN DISTRICT, ACEH PROVINCE
Authors: Irma Fitria  , Dewi Maritalia  , Herrywati Tambunan  
Published: November 2023

Background: Menopause is a physiological condition in women where the end of the reproductive period due to the cessation of the menstrual cycle for 12 consecutive months naturally. During menopause, the production of the hormones oestrogen and progesterone by the ovaries decreases and stops, thus causing changes in the hormonal system in the body that can affect physiological changes in the body as well as psychological changes and will have an impact on the woman's next life. Method: This study aims to identify physiological and psychological changes experienced by women during menopause. The research method is descriptive survey research, the population is all menopausal women who live in Bireuen Regency. The sampling technique used random sampling which was taken based on the Slovin formula totalling 392 respondents. The research instrument was a questionnaire distributed to respondents from 11 August to 05 September 2023 during the Elderly Posyandu at the Puskesmas. Data processing and analysis were carried out univariately for each variable of physiological changes and psychological changes using descriptive static tests. Result: The results of the study for physiological changes showed that the majority of respondents experienced difficulty sleeping, visual disturbances, had heart disease, did not experience respiratory problems, experienced changes in appetite, did not experience urinary disorders, experienced skin changes, experienced joint pain, experienced heat on the face. In psychological changes, they experience mood swings, feel tired and lack of enthusiasm and experience memory impairment. Conclusion: It is suggested that it is necessary to provide special support and attention to women in menopause so that they can go through menopause comfortably and happily so that it will reduce the level of dependence on others.
Using the ISO 9705 Room Corner Test for Smoke Toxicity Quantification of Oriented Strand Board
Authors: Peck Gabrielle 
Published: November 2023

As smoke toxicity is unregulated outside of the mass transport industry, there is no set methodology for assessing smoke toxicity of construction products, like OSB, on a large-scale. This research aims to assess the novel design of a modified ISO 9705 room corner test designed for smoke toxicity quantification. Three tests conditions will be assessed to determine if restriction of ventilation is enough to force a fire to transition to under-ventilated flaming, or if the fuel loading is much more important in affecting the fire severity and fire condition.
The research found that fuel loading and test geometry has more significant impact on the fire condition than restricting the ventilation. While imposing restrictions on the test rooms ventilation did increase the equivalence ratio, it was not sufficient enough to force the transition into under-ventilated flaming. The addition of a door to the test room did not force the fire to transition to under-ventilated flaming. When doubling the fuel loading, there was sufficient fuel for the fire to transition to under-ventilated flaming. This research has provided the experimental methodologies to assess smoke toxicity at a range of ventilation conditions on a large-scale.
Mapeando as disparidades socioeconômicas de saúde urbana: um estudo comparativo entre seis capitais brasileiras
Authors: Passarelli-Araujo Hisrael 
Published: November 2023

A cidade é um modo de viver, pensar e sentir. O modo de vida urbano é capaz de produzir ideias, comportamentos, valores e conhecimentos, mas também pode acirrar disparidades socioeconômicas e de saúde da população que ali reside. Este artigo examina as disparidades em saúde urbana em seis capitais brasileiras: São Paulo, Rio de Janeiro, Salvador, Fortaleza, Belo Horizonte e Manaus. Para quantificar e mapear as disparidades intraurbanas nesses espaços, foram utilizados os dados do Censo Demográfico de 2010 para a aplicação do índice de saúde urbana (ISU), uma métrica que sintetiza oito diferentes variáveis socioeconômicas e de saneamento desagregadas por setores censitários. Os resultados são discutidos à luz de três vertentes teóricas: a diferenciação centro-periferia; abordagem econômica da saúde; e epidemiologia social. As descobertas desse estudo revelam que os setores censitários que abrangem populações com maior status socioeconômico e melhores condições de saneamento apresentaram índices de saúde urbana mais elevados do que os da periferia da cidade. Há indícios de melhores indicadores de saúde urbana para o Rio de Janeiro e São Paulo, em comparação com as demais capitais analisadas. No entanto, há importantes nuances em cada uma das seis cidades estudadas, especialmente quando se atribuem diferentes pesos às variáveis que compõem o ISU, apesar da marcada segregação espacial comum a todas elas. Considerar as distinções dentro do espaço urbano é uma estratégia fundamental para a compreensão desses aspectos sociais e econômicos e seus potenciais desdobramentos nas condições de saúde da população.
Multiphase Multicomponent Transport Modeling of Cyclic Solvent Injection in Shale Reservoirs
Authors: Ma Ming , Emami-Meybodi Hamid 
Published: November 2023

Summary
A thorough understanding of fluid transport in ultratight shale reservoirs is crucial for designing and optimizing cyclic solvent injection processes, known as huff ’n’ puff (HnP). We develop a two-phase multicomponent numerical model to investigate hydrocarbon and solvent transport and species mixing during HnP. Unlike the conventional modeling approaches that rely on bulk fluid (advective) transport frameworks, the proposed model considers species transport within nanopores. The chemical potential gradient is considered the driving force for the movement of nonideal fluid mixtures. A binary friction concept is adopted that considers friction between different fluid molecules and between fluid molecules and pore walls. After validating the developed model against analytical solutions and experimental data, the model examines solvent HnP enhanced oil recovery (EOR) mechanisms by considering four-component oil and Eagle Ford crude oil systems. The impacts of injection pressure, primary production duration, soaking time, and solvent type on the oil recovery are examined. The results reveal that the formation of a solvent-oil mixing zone during the huff period and oil swelling and vaporization of oil components during the puff period are key mechanisms for enhancing oil recovery. Furthermore, the incremental recovery factor (RF) increases with injection pressure, even when the injection pressure exceeds the minimum miscibility pressure (MMP), implying that MMP may not play a critical role in the design of HnP in ultratight reservoirs. The results suggest that injecting solvents after a sufficient primary production period is more effective, allowing reservoir pressure depletion. Injecting the solvent without enough primary production may result in significant production of the injected solvent. The results show that the solvent-oil mixing zone expands, and the solvent recycling ratio decreases as soaking time increases. However, short soaking periods with higher HnP cycles are recommended for improving oil recovery at a given time frame. Finally, CO2 HnP outperforms CH4 or N2 HnP due to the higher ability of CO2 to extract a larger amount of intermediate and heavy components into the vapor phase, which has higher transmissibilities as compared with the liquid phase.
Genetic associations of persistent opioid use after surgery: a hypothesis-driven analysis of high-value genetic variants in the Michigan Genomics Initiative dataset
Authors: Brummett Chad , Annis Aubrey , Gunaseelan Vidhya , Smith Albert , Abecasis Goncaol , Larach Daniel , Zawistowski Matthew , Frangakis Stephan 
Published: November 2023

Abstract
Persistent opioid use after surgery is a common morbidity outcome associated with subsequent opioid use disorder, overdose, and death. While phenotypic associations are known, genetic associations remain unidentified. Here, we conducted the largest genetic study of persistent opioid use after surgery: a candidate analysis among non-Hispanic, European-ancestry Michigan Genomics Initiative participants (3,198 cases and 36,321 surgically exposed controls; 794 cases and 32,656 controls in an “opioid-naive” subanalysis) of high-value genetic variants from 72 opioid-related studies. Associations (p < 0.05) occurred at 14 of 77 variants spanning 23 genes. Two highly referenced genes, OPRD1 and DRD2/ANKK1, had no signals. Eleven occurred in OPRM1 (most significant: rs79704991-T, OR = 1.17, p = 8.7×10− 5). Other associations were rs10886472-GRK5 (p = 0.028), rs4633-COMT (p = 0.017), and rs4680-COMT (p = 0.016). Associations at previously identified OPRM1 variants suggest common biology between persistent opioid use and opioid use disorder, establishing a genetically informed component for the recently described concept of preaddiction patients who receive opioid prescriptions. Lack of significant associations at other variants challenges previous studies’ reliability.
FluCare: results from a randomised feasibility study of a complex intervention to increase care home staff influenza vaccination rates
Authors: Wright David , Patel Amrish , Blacklock Jeanette , Bion Veronica , Birt Linda , Bryant Terry , Clark Allan , Cook Luke , Griffiths Alys , Guillard Cecile , Hammond Amber , Holland Richard , Jones Andy , Jones Liz , Katangwe-Chigamba Thando , Pitcher Jennifer , Ruby Po , Scott Sion , Sims Erika , Stirling Susan , Wagner Adam 
Published: November 2023

Abstract
Background
To protect care home residents, annual staff influenza vaccination uptake is recommended to be greater than 75%. In the UK it is under 40%. With barriers and enablers to care home staff flu vaccine uptake identified, the purpose of this study was to feasibility test a theory informed intervention to improve vaccination rates.
Methods
This was a five-arm (one intervention, four different control) study designed to inform the development of a definitive trial protocol. The intervention comprised of videos/posters to change vaccination attitudes, on-site clinics to increase access, a financial incentive for homes to reach target, and monthly monitoring of vaccination uptake. Control arms consisted of a mix of monthly or end of the study monitoring and provision of informational materials to identify the most suitable control arm for a definitive trial.
Care homes were recruited via sector associations and purposively allocated. The feasibility outcomes were: ability to recruit enough homes; data quality (variables reported, variable completeness and consistency with a national reporting system); intervention implementation; control arm reactivity bias and signal of efficacy. Staff vaccination data was collated from homes and via a national healthcare tracking system. Process evaluation and economic data collation were undertaken to optimise intervention and research design.
Results
Ten homes were recruited as per target within 11 weeks. Recruitment delays meant intervention delivery began towards end of flu season. Only 2 clinics took place in each home. All homes in intervention and chosen control arm (monthly monitoring only) reported all variables with over 90% completeness. There was a 15% difference between control homes’ reported vaccination rates and that in the national healthcare tracker, home reported data was more reliable. Signal of efficacy: intervention arm had a vaccination rate 13.6% higher than control arm. Bias: control arm did not have a higher vaccination rate than usual care control.
Conclusions
Better recruitment processes, earlier start in flu season, and data collection direct from care homes are required for a definitive trial. A control arm of monthly monitoring only was identified as optimal for data collection purposes and minimising reactivity bias. The signal of efficacy was acceptable.
Trial registration ISRCTN 14727552 Registered on 27/08/2021. Secondary identifiers: IRAS 305371
Topic modeling discovers trending topics in global research on the ecosystem impacts of microplastics
Authors: Gong Kailin , Hu Shuangqing , Zhang Wei , Peng Cheng , Tan Jiaqi 
Published: November 2023

Abstract
The ecological threats of microplastics have sparked research worldwide. However, changes in the topics of microplastic research over time and space have not been evaluated quantitatively, making it difficult to identify the next frontiers. Here, we apply topic modeling to assess global spatiotemporal dynamics of microplastic research. We identified nine leading topics in current microplastic research. Over time, microplastic research topics have switched from aquatic to terrestrial ecosystems, from distribution to fate, from ingestion to toxicology, and from physiological toxicity to cytotoxicity and genotoxicity. In most of the nine leading topics, a disproportionate amount of independent and collaborative research activity was conducted in and between a few developed countries which is detrimental to understanding the environmental fates of microplastics in a global context. This review recognizes the urgent need for more attention to emerging topics in microplastic research, particularly in regions that are heavily impacted but currently overlooked.
Impact of Advanced Reproductive Age on Mitochondrial Metabolism of Bone Marrow Mesenchymal Stem Cells from Infertile Women: Implications for Mitochondrial Transplantation.
Authors: Wang Dandan , Chen Weixi , Chang Yajie , Yao Deyang , Liu Guihua , Huang Rui , Fang Cong , Zhou Chuanchuan , Jia Lei , Zhang Zhiqiang , Mai Huisi , Liang Xiao-yan 
Published: November 2023

Abstract

The decline in oocyte quality due to mitochondrial dysfunction is a frequent cause of infertility in women of advanced reproductive age. Autologous bone marrow mesenchymal stem cells could serve as a source of transplanted mitochondria for infertility treatment. However, the status of transplanted mitochondria may affect therapeutic potential. Although the effects of donor age and long-term culture on BMSC quality have been previously documented, it remains unclear whether advanced reproductive age and in vitro culture affect the mitochondrial metabolism of BMSCs from infertile women.Methods: BMSCs from young (25-30 years) and older (38- 45 years) infertile women were cultured and collected at passage 4 (P4) to P7. We evaluated their surface markers, proliferation capacity, mitochondrial oxygen consumption rate (OCR), reactive oxygen species (ROS), membrane potential (activity), ultrastructure, and the transcriptomic analysis of 38 mitochondrial processes (mito-processes).Results: Both age groups of BMSCs exhibited the stable expression of surface markers, decreased proliferation capacity, and increased mitochondrial OCR and ROS production with increasing passage. There were no differences between the two age groups in terms of these indexes. For transcriptomic analysis, only two mito-processes changed for BMSCs from the older group at consecutive passages, showing upregulation of ROS defense (MPV17L) and mitochondrial carrier (UCP2). In contrast, in the young group, P5 BMSCs showed upregulation of nine mito-processes, including OXPHOS, apoptosis, translation, and P6-P7 showed consistent upregulation of calcium signaling and transport (EFHD1) and downregulation of four mito-processes in total. Compared with the older group, the young group showed differences in fifteen mito-processes, most of which negatively affected mitochondrial metabolism.Conclusions: Advanced reproductive age has little impact on the mitochondrial metabolism of BMSCs from infertile women. Early-passage BMSCs are recommended for further application under the premise of controlling individual differences. Our work provides valuable guidance for the clinical application of autologous mitochondria from BMSCs, particularly for older women seeking infertility treatment.
Bioactive compounds enrichment in rabbit doe’s diet pre-and during pregnancy improved productive and reproductive performance and cost-effectiveness under hot climates
Authors: El-Speiy Mohamed Elsayed , Zeitoun Moustafa Mohamed , El-Sawy Mohamed A. , Sadaka Tarek A. , Abou-Shehema Bahaa A. , Abdella Mohamed M. , Shahba Hossam A. , Habib Mahmoud R. 
Published: November 2023

Abstract

This study aimed to investigate the effect of diet supplementation with a symbiotic (SY), bee pollen (BP), honey bee (HB), date palm pollen (DPP) and their mixture (MIX) on female rabbit productive and reproductive performances under desert hot climates. Seventy-two Californian does of 5 months age and average body weight of 3250 ± 78.2g was randomly allotted into six groups. All does were orally received 3 ml distilled water for 10 days before mating and 28 days during pregnancy. Treatments were repeated for four consecutive parities. The first group was served as control (C) given distilled water only, however the second, third, fourth and fifth groups were supplemented with 3ml distilled water containing0.2 ml SY, 200 mg DPP,200 mg BP, 0.2 ml HB/doe per day, respectively. While, the sixth group does were given all previous ingredients (MIX). Sexual receptivity rate, fertility rate, kindling rate, and newborn traits were recorded. Also, maternal feed intake, feed conversion ratio, and digestibility coefficients were recorded. Treatment increased maternal body weight and daily gain with highest values (P < 0.05) in BP, SY, and MIX does. All treatments enhanced feed intake and feed conversion ratio (FCR) compared with control. Number services per conception decreased (P < 0.01), while litter size and weight and survival at birth and weaning increased (P < 0.01) in treated than control does. Treated does produced more milk than control. All digestibility coefficients were improved (P < 0.01) in treated does. In conclusion, supporting rabbit does pre- and during pregnancy with diets supplemented with a mixture of honey bee, date palm pollen, bee pollen, and synbiotic improved the productive and reproductive performances of rabbit does and their offspring.
Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin
Authors: Pusnik Jernej , Zorn Jasmin , Monzon-Posadas Werner , Peters Kathrin , Osypchuk Emmanuil , Blaschke Sabine , Streeck Hendrik 
Published: November 2023

Abstract
Several studies have suggested the imprinting of SARS-CoV-2 immunity by original immune challenge without addressing the formation of the de novo response to successive antigen exposures. As this is crucial for the development of the original antigenic sin, we assessed the immune response against the mutated epitopes of omicron SARS-CoV-2 after vaccine breakthrough. Our data demonstrated a robust humoral response in thrice-vaccinated individuals following omicron breakthrough which was a recall of vaccine-induced memory. The humoral and memory B cell responses against the altered regions of the omicron surface proteins were impaired. The T cell responses to mutated epitopes of the omicron spike protein were present due to the high cross-reactivity of vaccine-induced T cells rather than the formation of a de novo response. Our findings, therefore, underpin the speculation that the imprinting of SARS-CoV-2 immunity by vaccination may lead to the development of original antigenic sin if future variants overcome the vaccine-induced immunity.
SpatialPrompt: spatially aware scalable and accurate tool for spot deconvolution and domain identification in spatial transcriptomics
Authors: Yadav Pankaj , Swain Asish , Pandit Vrushali , Sharma Jyoti 
Published: November 2023

Abstract

Efficiently mapping of cell types in situ remains a major challenge in spatial transcriptomics. Most spot deconvolution tools ignore spatial coordinate information and perform extremely slow on large datasets. We introduce SpatialPrompt, a spatially aware and scalable tool for spot deconvolution and domain identification. SpatialPrompt integrates gene expression, spatial location, and single-cell RNA sequencing (scRNA-seq) dataset as reference to accurately infer cell-type proportions of spatial spots. At the core, SpatialPrompt uses non-negative ridge regression and graph neural network to efficiently capture local microenvironment information. Our extensive benchmarking analysis using human prefrontal cortex dataset demonstrated superior performance of SpatialPrompt over 11 existing tools. On mouse hippocampus dataset, SpatialPrompt achieves spot deconvolution and domain identification within 2 minutes for 50,000 spots. Overall, domain identification using SpatialPrompt was 44 to 150 times faster than existing methods. We build a database housing 40 plus curated scRNA-seq datasets for seamless integration with SpatialPrompt for spot deconvolution.
Evaluation of The Effect of Thermocycling on The Trueness And The Precision of Digital Fabricated Complete Denture Bases
Authors: Helal Mohamed , Zeidan Ahmed 
Published: November 2023

Abstract

Background
Many denture base materials are available nowadays in the market, with little data available regarding its dimensional stability after exposure to the oral environment.
Purpose
was to evaluate the effect of thermocycling on the trueness and precision of digital fabricated complete denture bases (CDBs) (milled and 3-dimensional (3-D) printed CDBs) and conventional CDB.
Materials and methods
Maxillary completely edentulous stone model was used and scanned for production a standard tessellation language (STL) file that was imported to a metal milling machine software to produce the metal model that was used to fabricate 30 CDBs, according to the construction technique the CDBs were divided into three groups (n = 10 each) as follows: Group 1, CAD-CAM milled CDBs; Group 2, 3-D printed CDBs; and Group 3, conventional compression molded CDBs. The CDBs of all groups were scanned after fabrication, and the different CDBs were scanned and evaluated CDBs before and after thermocycling using the superimposition technique. Data were analyzed using one-way-ANOVA, Tukey’s post hoc, and paired t tests.
Results
Before and after thermocycling there were a significant difference in the trueness between the CAD-CAM milled, 3-D printed, and conventional compression molded CDBs (P < 0.05). There was a significant difference in the precision within each type of different CDBs before and after thermocycling (P < 0.05). Conclusion: the trueness of the CAD-CAM milling system in CD fabrication is superior to that of the 3-D printing and conventional compression molding systems either before or after thermocycling. The thermocycling had significant effect on the precision of milled CAD-CAM, 3-D printed and conventional compression molded CDBs. Conventional compression molding system in complete denture construction is the most negatively affected fabrication method by thermocycling in the aspect of trueness and precision.