bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is rheumatoid arthritis a neglected comorbidity in neurofibromatosis type 1?
Authors: ERTURK Adem , SARI Alper , AKÇİN Ali İzzet , UYSAL Ali Sadri , ELMAS Muhsin , TURAN Çağrı 
Published: October 2023

Aims: Neurofibromatosis type 1 (NF-1) is a relatively rare disorder with autosomal dominant inheritance. Despite current reports highlighting the association between NF-1 and some rheumatic diseases (e.g., systemic lupus erythematosus, juvenile idiopathic arthritis, ankylosing spondylitis, and antiphospholipid antibody syndrome), the literature seems to have missed focusing on its relationship with rheumatological disorders. Hence, the present study attempted to explore definite NF-1 molecular genetic mutation in association with accompanying rheumatic diseases, particularly rheumatoid arthritis.
Methods: The patients (n=23) aged 18 years who were diagnosed with NF-1 genetic mutation between 2010-2022 in the medical genetics department of our university were recruited for medical examination regarding rheumatic disorders in our rheumatology outpatient clinic.
Results: There were a total of 23 patients in this study, 14 (60.9%) males and 9 (39.1%) females, with a mean age of 27.4±9.2 years (18-51 years). As a result, 4 (17.3%) patients were diagnosed with rheumatoid arthritis (RA), 3 with seropositive RA, and one with seronegative RA. Of the diagnoses, two were established RA, and two were early RA. All patients with RA had a positive metacarpophalangeal joint (MCP) squeeze test and experienced pain in bilateral hands and wrists and morning stiffness for more than 45 min.
Conclusion: While the community prevalence of RA is about 1%, it is noteworthy that we detected RA in 17.3% of our patients. In the follow-up of patients with NF-1, routine examinations for pain in bilateral hands and wrists, morning stiffness over 45 minutes, and positivity of the MCP squeeze test are thought to allow early diagnosis of RA and, thus, relevant therapies.
Miliary cerebral metastases: prevalence and radiological findings
Authors: YALTIRIK BİLGİN Ezel , ÜNAL Özkan 
Published: October 2023

Aims: Miliary cerebral metastases, also known as carcinomatosis encephalitis, represent an unusual form of metastatic disease in the brain. Due to their rarity, limited literature is available, restricting our understanding of this condition. This study aimed to evaluate the prevalence and imaging characteristics of miliary cerebral metastases in a cohort of metastatic patients.
Methods: A retrospective review was conducted on approximately 618 contrast-enhanced MRI scans from patients with metastatic disease who had not undergone surgical intervention or received radiotherapy. Cases of miliary cerebral metastases were identified and analyzed. Demographic data, primary cancer types, non-contrast CT and MRI findings of miliary metastasis cases were evaluated.
Results: Miliary cerebral metastases were identified in 6 out of the 618 metastatic patients included in the study. The radiological features included small, disseminated hyperintense lesions visible on post-contrast T1-weighted images. These lesions were diffusely scattered throughout the brain, predominantly at the grey-white matter junction.
Conclusion: Our findings highlight the rarity of miliary cerebral metastases, supporting the limited cases reported in the literature. These findings underscore the need for increased clinical awareness and further research into this condition. High-resolution, contrast-enhanced MRI plays a vital role in detecting and characterizing miliary cerebral metastases, aiding in their management.
A detailed analysis of thyroid disorders in autoimmune liver diseases
Authors: KESKİN Çağlar , GÖKÇAY CANPOLAT Asena , CANLAR Şule , CİNEL Murat , DEMİR Özgür , ŞAHİN Mustafa , EMRAL Rıfat , KESKİN Onur , ÇORAPÇIOĞLU Demet 
Published: October 2023

Aims: Extrahepatic autoimmune diseases are frequently encountered in patients with autoimmune liver diseases (AILD). There is a very limited data in the literature on the incidence of autoimmune thyroid diseases in AILD and the characterization of thyroid diseases in these patients. This study evaluated frequency and clinical features of thyroid disorders in AILD.
Methods: We compared clinical and laboratory data and thyroid ultrasonography findings of 100 patients with AILD and 48 healthy controls.
Results: The frequency of autoimmune thyroid disease and nodularity was higher in the AILD group compared to the control group (34 % vs 12.1 %; p
Assessing the effects of asthma attack simulation on cognitive, psychomotor, and affective learning in nursing students: a randomized controlled study
Authors: ÜNAL Eda 
Published: October 2023

Aims: Asthma is a global health problem. Nursing students, who play a key role in managing asthma attack, should be capable of recognising and responding to asthma symptoms. This research aimed to assess the repercussions of asthma attack simulation training on nursing students cognitive, psychomotor, and affective learning domains.
Methods: A randomised controlled trial was used in this study. Fourth-year nursing students with no prior simulation training experience were recruited. This research randomly divided participants into two distinct groups: a simulation group, consisting of 53 members, and a control group, with 62 members. Each group received 100 hours of standard training, and only the simulation group received 210 hours of asthma attack simulation training instruction based on Bloom's taxonomy the following day. A knowledge questionnaire was used to evaluate nursing students' cognitive learning on asthma attacks right after theoretical training and three months afterwards. The Objective Structured Clinical Examination was used as a standardised evaluation instrument to evaluate students' psychomotor learning, and the emotional learning, empathy, motivation, self-efficacy, and anxiety levels of nursing students were assessed using a Likert scale ranging from 1 to 10 three months after their theoretical training.
Results: Asthma attack cognitive, psychomotor, and emotional learning of nursing students in the Simulation group improved after the intervention compared to the control group (p
Extra corporeal membrane oxygenation therapy in acute respiratory distress syndrome due to Coronavirus-2019 (COVID-19): a retrospective study
Authors: ERDOĞAN Cem , AYAR Işılay 
Published: October 2023

Aims: Extra corporeal membrane oxygenation (ECMO) has been used as a supportive treatment in ARDS due to COVID-19. Although different results have been reported in the literature regarding its efficacy, ECMO is recommended as a salvage therapy for severe forms of the disease after standard therapy fails. In our study,we aimed to evaluate the survival outcomes of patients supported with ECMO for COVID-19.
Methods: Our study was conducted by scanning the data of consecutive adult patients hospitalized in our intensive care unit due to COVID-19. The ECMO process was planned according to the Extracorporeal Life Support Organization (ELSO) and Berlin criteria.
Results: 51 patients hospitalized for acute respiratory failure due to COVID-19 were taken to ECMO. Demographic data of patients; 39 (76.5%) men and 12 (23.5%) women. 46 (90.2%) of the patients died. The mean intubation time before ECMO is 3.9 days, and the mean time for non-invasive mechanical ventilation is 5.8 days. The mean PaO2 value before ECMO was79.09 mmHg, the mean PCO2 value was 63.62 mmHg and the mean PaO2/FiO2 ratio was 82.80.
Conclusion: The use of ECMO by considering prognostic factors and guidelines is seen as factors that increase the chance of success.Despite the fact that the patients were admitted to ECMO in accordance with the guidelines in our study, the high mortality rate suggests that there is a need for investigation of other supportive treatments and studies to reduce ECMO complications.
Histopathological evaluation of the effects of sildenafil on organ damage in a diabetic rat model
Authors: KARA Mehmet , BAYKAN Halit , ÖNAL Esra , YILDIRIM Ayşegül Burçin , KARABULUT Derya 
Published: October 2023

Aims: In this study, it was aimed to show the effects of sildenafil on heart, liver and kidney tissues histopathologically by creating an experimental diabetes model with streptozocin.
Methods: Male adult Sprague dawley rat (48) was used in the study. The rats were first divided into three groups as control group, the diabetes group and the diabetes+sildenafil group. Each group was divided into two groups within itself. Streptozotocin 40 mg/kg was administered intraperitoneally to the rats in the groups that would develop diabetes and diabetes+sildenafil diabetes. Rats with blood glucose levels of 250 mg/dl and above after 48 hours were considered diabetic. Sildenafil citrate 10mg/kg/day was given by gavage to the diabetes+sildenafil group. At the end of the experiment heart, liver and kidney tissues were placed in formaldehyde solution. Hematoxylin-Eosin staining was applied to the sections taken. Histological changes in the stained sections were evaluated by a histologist. Histological evaluation was performed semi-quantitatively in heart, liver and kidney tissue. In the assessment, the findings of the tissues were scored and statistical analysis was performed.
Results: Histological findings of heart, liver and kidney tissues were examined. It was determined that less organ damage was seen in the diabetes+sildenafil group compared to the Diabetes group.
Conclusion: In our study, it has been demonstrated histologically that sildenafil can be a drug that has an antioxidant effect in tissue by helping to protect cell structure and architecture against heart, liver and kidney tissue damage caused by diabetes. It should not be overlooked that it is important to determine the appropriate dose and frequency of use of sildenafil in revealing these effects.
Individualized fluoroscopic lateral femoral neck view for fixation of hip fractures in the lateral decubitus position
Authors: UĞUR Fatih 
Published: October 2023

Aims: The aim of this study is to evaluate whether displaced hip fractures can be reduced and nailed properly in the lateral decubitus position without using a traction table with Proximal Femoral Nail Antirotation as a fixation device with inlet flouroscopic view.
Methods: In this retrospective study, 58 patients with hip fractures who were treated with Proximal Femoral Nail Antirotation in a single center were evaluated to determine the efficacy of the inlet fluoroscopic image. The postoperative X-rays of the patients underwent a comprehensive evaluation including the tip-apex distance, the quality of fracture reduction, and the positioning of the screw. The length of hospital stay, postoperative, and total hospital stays were evaluated. We propose personalized fluoroscopy positioning method for the reduction and internal fixation of hip fractures, eliminating the need for a traction table.
Results: The mean age of the patients was 78.43±11.67 years. By inlet viewing of the hip the most common placement of the integrated compression screws on postoperative radiographs was found to be 63.8% in Cleveland zone 5 and an increase in the femoral neck angle mean was 133,6° resulted in a significant decrease in the postoperative hospital stay of which mean was 3.95 days . The tip-apex distance was 19 mm as a mean.
Conclusion: The nailing of proximal femoral fractures using a lateral decubitus position and neutral fluoroscopy view may not achieve optimal quadrant placement of the nail. However, by repositioning the C-arm fluoroscopy with a 45-degree inlet angulation from the initial reference point, aligned with the femur and considering individual adduction, an enhanced lateral visualization of the femoral neck can be achieved, which will also help reduce potential complications during surgery.
Full-Range Yaw Prediction: A Multi-View Approach for 3D Head Model Pose Estimation Using Convolutional Neural Networks
Authors: Heredia-Lidón Álvaro , Martínez-Abadías Neus , Sevillano Xavier 
Published: October 2023

Head pose estimation, a crucial task in computer vision, involves determining the orientation of a person’s head in 3D space through yaw, pitch, and roll angles. While recent techniques present excellent results in estimating head pose from a single 2D RGB image when the head faces the camera directly, few methods exist for pose estimation from arbitrary viewpoints. This problem is emphasised when the input data is in 3D, such as heads reconstructed models from magnetic resonances, where an accurate estimation of the pose is necessary for diagnostic purposes. To overcome these limitations, we make a first step by proposing a method for fine-grained head pose estimation across the full-range of yaw angles using 3D head synthetic models. Our approach involves transforming the 3D pose estimation problem into a multi-class 2D image classification problem by representing 3D head models as multi-view projection images. Leveraging a fine-tuned ResNet50 convolutional neural network, we tackle the task of head pose estimation with fine granularity of 5°, effectively discretizing the 360° yaw orientations. For the evaluation of our proposal, we train and test our models with the publicly available FaceScape and 3D BIWI datasets obtaining promising results.
Transformasi Peran Masjid Pada Zaman Modern: Studi Kasus Pada Masjid Agung dan Masjid Al-Azhom Kota Tangerang
Authors: Rusmiati Elis Teti 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui dan memahami transformasi peranan masjid di era modern, faktor-faktor yang memengaruhinya serta dampak dari transformasi peran tersebut bagi masyarakat sekitar. Lokus penelitian ialah Masjid Agung dan Masjid Al-Azhom yang terletak di Kota Tangerang Provinsi banten. Penelitian ini menggunakan pendekatan kualitatif yaitu penelitian yang menggunakan pendekatan naturalistik untuk menemukan pemahaman mengenai fenomena dalam suatu latar yang berkonteks khusus. Kesimpulan penelitian ini menunjukkan bahwa transformasi peran masjid pada zaman modern memiliki dampak yang signifikan dalam memenuhi kebutuhan spiritual, sosial, dan keagamaan masyarakat di sekitarnya. Faktor-faktor yang turut berpengaruh ialah: perubahan sosial dan budaya, kepemimpinan masjid, partisipasi jamaah, hubungan dengan lembaga dan komunitas lain, serta pemahaman terhadap kebutuhan dan aspirasi masyarakat sekitar. Adapun dampak transformasi peran tersebut terlihat dalam penguatan identitas keagamaan, pendidikan dan pembinaan keagamaan, pemberdayaan sosial, pembinaan karakter dan etika, serta mendorong kehidupan komunitas yang solid. Masjid Agung dan Masjid Al-Azhom di Kota Tangerang telah berhasil beradaptasi dengan perubahan zaman dan mengambil peran yang lebih luas dalam meningkatkan kualitas hidup dan memperkuat ikatan sosial dalam komunitas.
Peculiarities of the morphological composition, protein profile, and activity of aminotransferases in the blood of turkeys in the presence of keel “namins”
Authors: Fedyniak R. I. , Peleno R. A. 
Published: October 2023

A timely blood test is essential to detect possible abnormalities in the body. Blood somewhat objectively reflects the state of the internal environment in which all metabolic processes take place. The blood test is one of the most informative laboratory diagnostic tools, which provides essential information about the functional state of various organs and systems of the body. The work aimed to investigate the changes in morphological parameters, protein profile, and activity of aminotransaminases in the blood of turkeys in the presence of keel “namins”. The research was carried out at “Indykat” Ltd. in the village Kadubivtsi of the Lviv region on turkeys of the Big-6 breed on two groups of turkeys, 10 birds each. The turkeys of the control group were clinically healthy, and those of the experimental group had visible clinical signs of “namin” on the keel. The results of the research showed that the number of erythrocytes in the blood of clinically healthy birds was 2.5 ± 0.19 T/l, leukocytes – 21.8 ± 1.36 G/l, hemoglobin content – 90.5 ± 2.54 g/l, and the hematocrit was equal to 29.4 ± 1.44 %. In the presence of “namins” in the blood of turkeys, the number of leukocytes and hematocrit, compared to the control, was higher by 15.2 and 3.8 %, respectively, and the number of erythrocytes and hemoglobin content was lower by 16.1 and 11.3 %. Analyzing the leukogram of the blood of the turkeys of the research group, the appearance of basophilic leukocytes and young neutrophils was established, the number of which was 1.1 ± 0.08 and 0.2 ± 0.01 %, respectively. Compared to the control, the number of rod-shaped and segmented neutrophils was higher by 1.3 and 6.3 %, monocytes by 16.3 %, and eosinophils and lymphocytes were lower by 1.3 and 16.8 % and amounted to 6, 3 ± 0.27 and 41.1 ± 2.41 %. The level of total protein in the blood of birds in the pectoral muscles that developed and formed “namins” was 26.4 ± 1.35 g/l and was 6.7 % lower than that of the experimental group. In the presence of “namins” on the keels of turkeys, a 4.4 % higher level of globulins, which perform a protective function, and a 17.1 % lower amount of albumins were found. The pathological process that developed in the pectoral muscles of turkeys led to an increase in the activities of alanine aminotransferase and aspartate aminotransferase in the blood of turkeys to 32.4 ± 1.23 and 314.2 ± 14.2 units/l, which was more significant than indicators of the control group by 8.6 and 8.3 %, respectively.
Helminthiasis of wild ungulates: helminth fauna. Spread and features of prevention
Authors: Hunchak Yu. R. , Gutyj B. V. , Hunchak A. V. , Soltys M. P. 
Published: October 2023

Ensuring the veterinary and sanitary welfare of animals is essential. Parasitic diseases are especially dangerous for deer. Helminths cause considerable material damage to deer farms, mainly decreasing the productive, trophy, and marketable qualities of animals. This article studies the distribution and features of preventing helminthiasis of wild ungulates. In ungulate populations settled in new ecological conditions, helminth fauna formation depends on many factors. In particular, this process is influenced by the correct selection of the settlement area, the physiological state of animals, the organization of animal feeding, medical and preventive measures, etc. Among the main measures for preventing helminthiasis in deer in the conditions of their semi-free keeping (farms, aviaries), those that reduce the possibility of infection of animals with parasites common to domestic animals are also vital. Wild animals are much more often infected with helminths of domestic animals, and the most dangerous parasitosis for them are fasciolosis, parafasciolopsosis, cysticercosis, trichostrongylidosis of ruminants. Infection with nematodes Capillaria spp. is characteristic exclusively for red deer, and the intensity of infestation is higher for this species of ruminant ungulates in free-range conditions. According to some researchers, mecystocirosis and strongyloidosis are among the most common helminthiasis in deer, the infection with pathogens of which is 74.5 and 73.3 %, respectively. Parafasciolopsoses (IE – 5.9 %), nematodirus (IE – 5.9 %), and paramphistomatids (IE – 2.8 %) are found somewhat less often. Thus, the study of helminth fauna, the development and implementation of adequate means, and methods of prevention of parasites in wild animals acquire considerable relevance. There are several ways to prevent helminthiasis in hunting and aviary deer farms; when examining the land and choosing an area for aviaries for deer, a helminthological assessment should be taken into account; it is mandatory to examine animals for helminthiasis (parasitocenoses) and carry out deworming of all imported animals; carry out annual disinfestation of feeders, watering holes, places for feeding, protective structures for animals; it is crucial to rationally place biotechnical facilities in areas safe from parasitosis; infected animals with characteristic clinical signs of the disease must be culled. There is quite a lot of information in the available literature regarding the group method of using anthelmintics for deer.
Hypertonic treatment of acute respiratory distress syndrome
Authors: Li Weiyu , Martini Judith , Intaglietta Marcos , Tartakovsky Daniel M. 
Published: October 2023

Many viral infections, including the COVID-19 infection, are associated with the hindrance of blood oxygenation due to the accumulation of fluid, inflammatory cells, and cell debris in the lung alveoli. This condition is similar to Acute Respiratory Distress Syndrome (ARDS). Mechanical positive-pressure ventilation is often used to treat this condition, even though it might collapse pulmonary capillaries, trapping red blood cells and lowering the lung’s functional capillary density. We posit that the hyperosmotic-hyperoncotic infusion should be explored as a supportive treatment for ARDS. As a first step in verifying the feasibility of this ARDS treatment, we model the dynamics of alveolar fluid extraction by osmotic effects. These are induced by increasing blood plasma osmotic pressure in response to the increase of blood NaCl concentration. Our analysis of fluid drainage from a plasma-filled pulmonary alveolus, in response to the intravenous infusion of 100 ml of 1.28 molar NaCl solution, shows that alveoli empty of fluid in approximately 15 min. These modeling results are in accordance with available experimental and clinical data; no new data were collected. They are used to calculate the temporal change of blood oxygenation, as oxygen diffusion hindrance decreases upon absorption of the alveolar fluid into the pulmonary circulation. Our study suggests the extraordinary speed with which beneficial effects of the proposed ARDS treatment are obtained and highlight its practicality, cost-efficiency, and avoidance of side effects of mechanical origin.
Analysis of factors influencing crash injury severities at highway–rail grade crossings accommodating for unobserved heterogeneity
Authors: Se Chamroeun , Champahom Thanapong , Laphrom Wimon , Jomnonkwao Sajjakaj , Ratanavaraha Vatanavongs 
Published: October 2023

Introduction: This research aims to identify and understand the risk factors associated with injury severities in accidents occurring at highway–rail grade crossings in the context of the developing country, Thailand.Method: The mixed logit model was employed by analyzing crash data over 10 years, from 2012 to 2022.Results: The analysis revealed a number of significant factors associated with severe or fatal crashes. These included accidents that occurred between midnight and 6 a.m., collisions involving pickup cars or heavy trucks, roads with a “no overtaking zone” sign, intersections classified as Type B1 (defined by the presence of only warning posts and horizontal crossing barriers), and intersections without adequate traffic control devices. In contrast, hazard markers on pavements and traverse rumble strips were positively correlated with property damage only crashes, where no injuries were reported.Discussion: This study provides insights into contributory factors to accidents at highway–rail grade crossing. Based on these key findings, the study recommends increasing nighttime visibility at railway grade crossings, developing targeted education and training programs for pickup car and truck drivers, installing hazard markers and traverse rumble strips, and considering physical barriers, such as bollards or delineators, to discourage overtaking maneuvers near the railway crossing.