bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-system specialty pharmacy: Overview of a hybrid clinical model
Authors: Meadors Crystal , McPheeters Chelsey , Maier Chelsea , O’Reilly Emily 
Published: December 2023

Abstract

Purpose
The prevalence of specialty pharmacies has grown, especially within the hospital setting. These pharmacies have shown benefits in the areas of patient education and adherence, financial support, and patient and provider satisfaction. Currently, there are gaps in literature describing use of a hybrid clinical model in health-system specialty pharmacies.

Summary
The UofL Health – UofL Hospital Specialty Pharmacy (UofL Health SP) is attached to a retail pharmacy in a larger health system. Pharmacists in the UofL Health SP utilize a hybrid clinical model in which they split their time between working in a specialty clinic and staffing in the specialty pharmacy. The specialty pharmacy and its oncology satellite pharmacy each have a primary staffing pharmacist, and 5 other pharmacists participate in this hybrid clinical model. In addition to the specialty pharmacists, pharmacy technicians and patient care advocates support the operations of the specialty pharmacy and ensure financial access to medications for patients.

Conclusion
With the hybrid clinical model at UofL Health SP, there is increased workflow efficiency and better communication between specialty clinics and the specialty pharmacy, which results in a streamlined patient experience. Additionally, there has been an increase in specialty pharmacy prescriptions dispensed in the specialty pharmacy since the implementation of this hybrid clinical model.
Recent and anticipated novel drug approvals for 2023 and 2024
Authors: Rim Matthew H , Karas Brittany L , Barada Farah , Levitsky Andrew M 
Published: December 2023

Abstract

Purpose
Health-system pharmacists play a crucial role in monitoring the pharmaceutical pipeline to manage formularies, allocate resources, and optimize clinical programs for new therapies. This article aims to support pharmacists by providing updates on new and anticipated novel drug approvals.

Summary
Selected drug approvals anticipated in the 12-month period covering the fourth quarter of 2023 through the third quarter of 2024 are reviewed. The analysis emphasizes drugs selected from 58 novel drugs awaiting FDA approval that are expected to have significant clinical and financial impact in hospitals and clinics. The pipeline includes recently added drugs with various indications, including oncology, infectious diseases such as complicated urinary tract infection and pneumonia, and rare diseases.

Conclusion
Cellular and gene therapies continue to strengthen the pipeline as potential new treatment options for genetic disorders, rare diseases, and cancer. Additional diseases treated by new agents include pulmonary arterial hypertension, chronic obstructive pulmonary disease, diabetes, and obesity.
The Looming Future of Private Equity in Plastic Surgery
Authors: Shaffrey Ellen C , Attaluri Pradeep K , Wirth Peter J , Rao Venkat K 
Published: December 2023

Abstract
Private equity acquisition of independent private practices has grown dramatically in the last decade, with private equity firms increasingly investing in surgical specialties that practice in outpatient ambulatory centers. This trend has slowly started to creep into plastic surgery; therefore, understanding the concepts of private equity ownership in healthcare and its benefits and risks is critical. This article provides a fundamental economic background on private equity, describes its current state in healthcare, including trends in plastic surgery, and provides recommendations for plastic surgeons considering private equity acquisition.
In search of strategies for rural revitalization in China: Puhan’s approach to sustainable community development
Authors: Meng Qian , Gray Mel , Bradt Lieve , Roets Griet 
Published: December 2023

Abstract
Despite the central government’s rural reconstruction programme targeting rural villages, rural communities in contemporary China continue to face massive social, economic, and environmental challenges. This paper reports on a case study of a farmers’ cooperative in Puhan. Continual rural decline, alongside national economic reform and rural community development, provide the context for the case study. Well known to rural community development scholars in China, the Puhan cooperative represents an island of rural revitalization in a sea of rural decline. The paper begins with a discussion of the background to the study, the research design and objectives, and participatory observation method employed. Thereafter, it discusses sustainable community development and provides an analysis of the way in which the community development approach facilitates the attainment of sustainable development goals generally and in Puhan in particular. Focusing on the broader context of rural development in the context of national top-down policy-driven change, it examines the Puhan cooperative’s contribution to rural revitalization and the strengths and challenges encountered, given its adoption of bottom-up, grassroots community development. By outlining the lessons learnt from this case study research, the paper aims to enrich knowledge on the community development approach, sustainable community development, and rural revitalization in contemporary China.
Sucrose, NaCl, and citric acid suppress the metallic sensation of FeSO4
Authors: Tansaraviput Sasi , Nolden Alissa A 
Published: December 2023

Abstract
Metallic sensation is often described as unpleasant and can reduce acceptance of foods and beverages and compliance with medication. Masking and suppressing aversive sensations can help to improve acceptance of these products, with many successful strategies identified for bitterness. However, there are few studies investigating effective strategies for suppressing metallic sensation. This study aims to assess the effectiveness of mixture suppression to reduce the metallic sensation elicited from ferrous sulfate and examine whether individual differences in metallic sensation are associated with the effectiveness of suppression strategies. To achieve this, participants (n = 121) reported the intensity of suprathreshold concentrations of ferrous sulfate alone and in binary mixtures with three tastants, specifically, sucrose, citric acid, and sodium chloride. The results revealed that metallic sensation ratings were significantly lower for every binary mixture tested compared to ferrous sulfate presented in isolation. For 0.3 mM ferrous sulfate, sucrose was identified to be the most effective compound in suppressing metallic sensation, followed by citric acid and sodium chloride. For the 1.0 mM ferrous sulfate solutions, all tastants were equally effective at suppressing metallic sensation. In addition, there is a significant interaction between the perceived metallic intensity and the effectiveness of each strategy. These findings suggest that sucrose, citric acid, and sodium chloride have the potential to be effective in suppressing metallic sensation.
Hibernoma: a case report of a rare cardiac tumour
Authors: Cistulli David , Othman Farrah , Karim Rooshdiya , Puranik Rajesh 
Published: December 2023

Abstract

Background
A cardiac hibernoma is a rare phenomenon, with just a handful of reports in the literature. They are difficult to characterize with conventional imaging including echocardiography, computed tomography (CT), cardiac magnetic resonance (CMR), or positron emission tomography (PET). Their definitive diagnosis relies primarily on histopathology via either endovascular or surgical biopsy. Previous case reports have entailed surgical excision followed by histopathology; however, surgery may be unfavourable in some patients with increased perioperative risk.

Case summary
We present the case of a 57-year-old woman who was referred to our cardiology service with an interatrial lipomatous mass found incidentally on chest CT for assessment of rib fractures. She had 6 months of unexplained syncope, which was attributed to superior vena cava (SVC) compression demonstrated by chest CT. The mass had benign characteristics on echocardiography, CT, and CMR but was glucose-avid on PET, which indicated a possible malignancy such as liposarcoma. Her comorbid and very significant airways disease precluded her from surgical excision, so instead, endovascular biopsy was performed. Histopathology showed brown fat which was negative for mouse double minute 2 amplification on fluorescence in situ hybridisation testing; hence, a diagnosis was made of hibernoma, a rare benign tumour of brown fat. Given the benign diagnosis and her surgical risk with severe chronic obstructive pulmonary disease, a multidisciplinary recommendation was made favouring conservative management, with careful ongoing follow-up and the consideration of SVC stenting if symptoms progressed.

Discussion
The definitive diagnosis of a cardiac hibernoma is complex and relies heavily on histopathology due to the contradictory findings on chest imaging. Careful consideration of management within a multidisciplinary team setting is essential to achieve a successful outcome.
Aortic arch shape after arch repair predicts exercise capacity: a multicentre analysis
Authors: Mandell Jason G , Romanowicz Jennifer , Loke Yue-Hin , Ikeda Nobuyuki , Pena Emily , Siddiqi Umar , Hibino Narutoshi , Alexander Mark E , Powell Andrew J , Olivieri Laura J 
Published: December 2023

Abstract

Aims
Coarctation of the aorta is associated with long-term morbidity including decreased exercise capacity, despite successful repair. In the absence of discrete recoarctation, the haemodynamic mechanism remains unknown. This multicentre study evaluated the relationship between aorta shape, flow, and exercise capacity in patients after arch repair, specifically through the lens of aortic size mismatch and descending aortic (DAo) flow and their association with exercise.

Methods and results
Cardiac magnetic resonance, cardiopulmonary exercise test, and echocardiogram data within 1 year were analysed from 58 patients (age 28 ± 10 years, 48% male) across four centres with history of isolated arch repair. Aortic arch measurements were correlated with % predicted VO2max with subgroup analyses of those with residual arch obstruction, bicuspid aortic valve, and hypertension. Ascending aorta (AAo) to DAo diameter ratio (DAAo/DDAo) was negatively correlated with % predicted VO2max. %DAo flow positively correlated with VO2max. Sub-analyses demonstrated that the negative correlation of DAAo/DDAo with VO2max was maintained only in patients without arch obstruction and with a bicuspid aortic valve. Smaller aortic arch measurements were associated with both hypertension and exercise-induced hypertension.

Conclusion
Aorta size mismatch, due to AAo dilation or small DAo, and associated decreased %DAo flow, correlated significantly with decreased exercise capacity after aortic arch repair. These correlations were stronger in patients without arch obstruction and with a bicuspid aortic valve. Aorta size mismatch and %DAo flow capture multiple mechanisms of altered haemodynamics beyond blood pressure gradient or discrete obstruction and can inform the definition of a successful repair.
Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition
Authors: Urai Shin , Iguchi Genzo , Kanie Keitaro , Bando Hironori , Yamamoto Masaaki , Oi Yuka , Kashitani Yuya , Iida Keiji , Kanzawa Maki , Fukuoka Hidenori , Takahashi Michiko , Shintani Yasushi , Ogawa Wataru , Takahashi Yutaka 
Published: December 2023

Abstract
The pathogenesis of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis was gradually revealed as cases emerged. Our comprehensive analysis, including all reported cases, identified a new instance of anti-PIT-1 hypophysitis postimmune checkpoint inhibitor therapy. All 9 patients exhibited extremely low growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) levels; 2 had a slightly atrophic pituitary gland; 4 had thymoma, and 5 had malignant neoplasms of diffuse large B-cell lymphoma (DLBCL) and other origins. Patients with thymoma showed multiple autoimmune diseases. HLA-A*24:02 and/or A*02:06 were present in six and DR53 in 5 cases analyzed. High anti-PIT-1 antibody titers and ectopic PIT-1 expression in the cytosol and nucleus of the tumor tissues were observed in patients with thymoma or DLBCL, whereas it was exclusively observed in the nuclei of a bladder cancer patient. These findings provide new insights into the pathophysiology of paraneoplastic autoimmune hypophysitis.
Developmental process of the modern house shrew’s molars: implications for the evolution of the tribosphenic molar in Mesozoic mammals
Authors: Yamanaka Atsushi , Haider Yasin , Morita Wataru , Corfe Ian , Nakamura Norifumi , Goto Tetsuya 
Published: December 2023

Abstract
Phylogenetically, the tribosphenic molars—prototypes of multi-cusped cheek teeth in marsupial and placental mammals—are derived from the single-cusped conical teeth of reptiles through the addition of cusps. Ontogenetically, mammalian molars are formed through the interface between the dental epithelium and mesenchyme (future enamel–dentin junction), becoming geometrically complex by adding epithelial signaling centers, called enamel knots, which determine future cusp positions. To reevaluate cusp homologies in Mesozoic mammals from an ontogenetic perspective, this study tracked molar development in a living placental mammal species, the house shrew (Suncus murinus), whose molars are morphologically the least derived from tribosphenic prototypes. The development of shrew molars proceeded as if it replayed the evolutionary process of tribosphenic molars. The first formed enamel knots gave rise to the evolutionarily oldest cusps—upper paracone and lower protoconid. The order of formation of other enamel knots and their location in development seemed to trace the order of cusp appearance in evolution. The parallel relationship between ontogeny and phylogeny of mammalian molars, if any, suggests that a change in the timing between developmental events rather than a change in the morphogenetic mechanism itself, should have been a major causal factor for the evolutionary transformation of tooth morphology.
The fitness consequences of genetic divergence between polymorphic gene arrangements
Authors: Charlesworth Brian 
Published: December 2023

Abstract
Inversions restrict recombination when heterozygous with standard arrangements, but often have few noticeable phenotypic effects. Nevertheless, there are several examples of inversions that can be maintained polymorphic by strong selection under laboratory conditions. A long-standing model for the source of such selection is divergence between arrangements with respect to recessive or partially recessive deleterious mutations, resulting in a selective advantage to heterokaryotypic individuals over homokaryotypes. This paper uses a combination of analytical and numerical methods to investigate this model, for the simple case of an autosomal inversion with multiple independent nucleotide sites subject to mildly deleterious mutations. A complete lack of recombination in heterokaryotypes is assumed, as well as constancy of the frequency of the inversion over space and time. It is shown that a significantly higher mutational load will develop for the less frequent arrangement. A selective advantage to heterokaryotypes is only expected when the two alternative arrangements are nearly equal in frequency, so that their mutational loads are very similar in size. The effects of some Drosophila pseudoobscura polymorphic inversions on fitness traits seem to be too large to be explained by this process, although it may contribute to some of the observed effects. Several population genomic statistics can provide evidence for signatures of a reduced efficacy of selection associated with the rarer of two arrangements, but there is currently little published data that are relevant to the theoretical predictions.
The gender wage gap among health care workers across educational and occupational groups
Authors: Dill Janette S , Frogner Bianca K 
Published: December 2023

Abstract
Women perform 77% of health care jobs in the United States, but gender inequity within the health care sector harms women's compensation and advancement in health care jobs. Using data from 2003 to 2021 of the Annual Social and Economic Supplement of the Current Population Survey (CPS), we measured women's representation and the gender wage gap in health care jobs by educational level and occupational category. We found, descriptively, that women's representation in health care occupations has increased over time in occupations that require a master's or doctoral/professional degree (eg, physicians, therapists), while men's representation has increased slightly in nursing occupations (eg, registered nurses, LPNs/LVNs, aides, and assistants). The adjusted wage gap between women and men is the largest among workers in high-education health care (eg, physicians, advanced practitioners) but has decreased substantially over the last 20 years, while, descriptively, the gender wage gap has stagnated or grown larger in some lower education occupations. Our policy recommendations include gender equity reviews within health care organizations, prioritizing women managers, and realigning Medicare and Medicaid reimbursement policies to promote greater gender equity within and across health care occupations.
Feasibility of implementing patient-reported outcome measures into routine breast cancer care delivery using a novel collection and reporting platform
Authors: Tsangaris Elena , Hyland Colby , Liang George , O’Gorman Joanna , Huerta Dany Thorpe , Kim Ellen , Edelen Maria , Pusic Andrea 
Published: December 2023

Abstract

Objectives
imPROVE is a new Health Information Technology platform that enables systematic patient-reported outcome measure (PROM) collection through a mobile phone application. The purpose of this study is to describe our initial experience and approach to implementing imPROVE among breast cancer patients treated in breast and plastic surgery clinics.

Materials and Methods
We describe our initial implementation in 4 phases between June 2021 and February 2022: preimplementation, followed by 3 consecutive implementation periods (P1, P2, P3). The Standards for Reporting Implementation Studies statement guided this study. Iterative Plan-Do-Study-Act (PDSA) cycles supported implementation, and success was evaluated using the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework.

Results
Qualitative interviews conducted during the preimplementation phase elicited 4 perceived implementation barriers. Further feedback collected during each phase of implementation resulted in the development of brochures, posters in clinic spaces, and scripts for clinic staff to streamline discussions with patients, and the resolution of technical issues concerning patient login capabilities, such as compatibility with cell phone software and barriers to downloading imPROVE. Feedback also generated ideas for facilitating provider interpretation of PROM results. By the end of P3, 2961 patients were eligible, 1375 (46.4%) downloaded imPROVE, and 1070 (36.1% of those eligible, 78% of those who downloaded) completed at least 1 PROM.

Discussion and Conclusion
Implementation efforts across 2 surgical departments at 2 academic teaching hospitals enabled collaboration across clinical specialties and longitudinal PROM reporting for patients receiving breast cancer care; the implementation effort also highlighted patient difficulties with mobile app-based PROM collection, particularly around initial engagement.
Arthropod and mollusk pests of hemp, Cannabis sativa (Rosales: Cannabaceae), and their indoor management plan in Florida
Authors: Ahmed Muhammad Z , McKenzie Cindy L , Osborne Lance S 
Published: December 2023

Abstract
The first step in developing a pest management strategy is to know which pests can be found on the crop. Recently, the legal cultivation of hemp, Cannabis sativa (Rosales: Cannabaceae), has begun in Florida, and although hemp harbors one of the most diverse pest complexes globally, growers often do not consider the importance of pest identification until it is too late. This study aims to list arthropod and mollusk species reported on hemp in Florida to date. A total of 105 arthropod and mollusk species are reported on hemp in Florida from 8 insect orders and 2 non-insect orders. We found 78 species in Florida already reported in published literature, and 27 species are reported here on hemp for the first time. Even though 105 species in Florida are reported from hemp, not all can reproduce, complete their life cycle, and cause damage to hemp. Therefore, we divided them into 3 categories based on their pest potential: major (26), minor (72), and minor-to-major (7) pests. In addition, we provide representative images, a field guide, and easy-to-follow keys for hemp pest diagnostics. Our study provides the first comprehensive list of hemp pests known to occur in Florida. This will help extension agents, growers, regulators, and researchers scout and inspect hemp regardless of their background and let them know which hemp pest species are commonly found in Florida. We propose and discuss a management plan for pest species on hemp in indoor cultivation with a controlled environment. The pest list and the management plan proposed herein will help aid in the management of hemp pests and the detection of newly introduced hemp pests in Florida.
Impact of the COVID-19 Pandemic on Pediatric Preventive Health Care Among North Carolina Children Enrolled in Medicaid
Authors: Thakkar Pavan V , Scott Zeni , Hoffman Molly , Delarosa Jesse , Hickerson Jesse , Boutzoukas Angelique E , Benjamin Daniel K , Brookhart M Alan , Zimmerman Kanecia O , Moorthy Ganga S 
Published: December 2023

Abstract

Background
Children enrolled in private insurance had reduced preventive health care during the coronavirus disease 2019 (COVID-19) pandemic. However, the impact of the pandemic on children enrolled in Medicaid has been minimally described.

Methods
We used an administrative claims database from North Carolina Medicaid to evaluate the rates of well-child visits and immunization administration for children ≤14 months of age, and used a quasi-Poisson regression model to estimate the rate ratio (RR) of each outcome during the pandemic period (3/15/2020 through 3/15/2021) compared with the pre-pandemic period (3/15/2019 through 3/14/2020).

Results
We included 83 442 children during the pre-pandemic period and 96 634 children during the pandemic period. During the pre-pandemic period, 405 295 well-child visits and 715 100 immunization administrations were billed; during the pandemic period, 287 285 well-child visits and 457 144 immunization administrations were billed. The rates of well-child visits (RR 0.64; 95% CI, 0.64–0.64) and vaccine administration (RR 0.55; 95% CI, 0.55–0.55) were lower during the pandemic compared with the pre-pandemic period.

Conclusions
The rates of well-child visits and immunization administrations among North Carolina children enrolled in public insurance substantially decreased during the first year of the COVID-19 pandemic.