bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of multidrug-resistant Klebsiella pneumoniae infection in clinical setting in South-Eastern Asia: a systematic review and meta-analysis
Authors: Salawudeen Adamu , Raji Yakubu Egigogo , Jibo Garba Gidandawa , Desa Mohd Nasir Mohd , Neoh Hui-min , Masri Siti Norbaya , Di Gregorio Sabrina , Jamaluddin Tengku Zetty Maztura Tengku 
Published: December 2023

AbstractThe rising prevalence of multidrug-resistant (MDR) and extended-spectrum beta lactamase-resistant (ESBL) Klebsiella pneumoniae (K. pneumoniae) is an important global public health challenge. This threat is even more pertinent in clinical settings. Morbidity and mortality associated with this condition are alarming particularly in the developing regions of the world. A comprehensive evaluation of the epidemiology of this phenomenon will assist towards the global effort of reducing its burden. So, this systematic review and meta-analysis was conducted to evaluate the epidemiology of MDR K. pneumoniae in South-Eastern Asia (SEA). The study was done under the PRISMA guidelines and was preceded by the development of a priori protocol. The protocol was then registered in PROSPERO—the public registry for systematic reviews. Seven important outcomes which include the assessment of the overall MDR K. pneumoniae prevalence were designed to be evaluated. A literature search was carried out in five selected electronic databases and 4389 were screened. Of these articles, 21 studies that met the eligibility criteria were included in the review. Relevant data were extracted from the included studies. By conducting a quality effect meta-analysis, the pooled prevalence for MDR and ESBL K. pneumoniae in SEA was estimated at 55% (CI 9–96) and 27% (CI 32–100) respectively. The review also identified ESBL genes types of allodemic situations occurring mostly in respiratory tract infections. The high prevalence of MDR and ESBL K. pneumoniae in this subregion is highly significant and of both public health and clinical relevance. Overall, the findings of this review will assist in the effective prevention and control of this threat in SEA.
The coexistence of psychological drivers and deterrents of consumers’ willingness to try cultured meat hamburger patties: evidence from South Africa
Authors: Tsvakirai C. Z. , Nalley L. L. 
Published: December 2023

AbstractThe widespread consumption of alternative meat products, such as plant-based alternatives in the hamburger patty market, has provided insights into the potential of commercially produced cultured meat. Evidence from previous alternative meat studies shows mixed results on whether experience with commercially available alternative protein will help to overcome or compound consumers’ concerns about cultured meat. This study investigates the effect that South African consumers’ implicit perceptions developed by experience with and from attitudes about novel products and perceptions about the product could influence their acceptance of cultured meat. South African consumers’ perceptions were estimated using opinion statements, and the level of agreement was ranked on a Likert scale. Composite indices were extracted from these data, which were regressed against consumers’ willingness to try cultured meat burger patties. Results suggest that the implicit perceptions (worldviews) promoted both neophobic and neophilic attitudes, while explicit (product-specific) perceptions indicated that concerns of anticipated social, cultural and economic disruptions may drive non-adoption. The study’s results suggest targeted marketing approaches that can utilise implicit perceptions to promote consumer adoption. Other results indicated the areas of concern that should be addressed to facilitate acceptance and the population groups that could be targeted as early adopters. These results contribute to a better understanding of the potential market for cultured meat in the world's eighth-largest per capita beef consumer and provide insights into drivers and deterrents of cultured meat in an environment that struggles with food security.
AI and machine learning for soil analysis: an assessment of sustainable agricultural practices
Authors: Awais Muhammad , Naqvi Syed Muhammad Zaigham Abbas , Zhang Hao , Li Linze , Zhang Wei , Awwad Fuad A. , Ismail Emad A. A. , Khan M. Ijaz , Raghavan Vijaya , Hu Jiandong 
Published: December 2023

AbstractSustainable agricultural practices help to manage and use natural resources efficiently. Due to global climate and geospatial land design, soil texture, soil–water content (SWC), and other parameters vary greatly; thus, real time, robust, and accurate soil analytical measurements are difficult to be developed. Conventional statistical analysis tools take longer to analyze and interpret data, which may have delayed a crucial decision. Therefore, this review paper is presented to develop the researcher’s insight toward robust, accurate, and quick soil analysis using artificial intelligence (AI), deep learning (DL), and machine learning (ML) platforms to attain robustness in SWC and soil texture analysis. Machine learning algorithms, such as random forests, support vector machines, and neural networks, can be employed to develop predictive models based on available soil data and auxiliary environmental variables. Geostatistical techniques, including kriging and co-kriging, help interpolate and extrapolate soil property values to unsampled locations, improving the spatial representation of the data set. The false positivity in SWC results and bugs in advanced detection techniques are also evaluated, which may lead to wrong agricultural practices. Moreover, the advantages of AI data processing over general statistical analysis for robust and noise-free results have also been discussed in light of smart irrigation technologies. Conclusively, the conventional statistical tools for SWCs and soil texture analysis are not enough to practice and manage ergonomic land management. The broader geospatial non-numeric data are more suitable for AI processing that may soon help soil scientists develop a global SWC database.
Graphical Abstract
Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study
Authors: Kunimoto Yusuke , Matamura Ryosuke , Ikeda Hiroshi , Horiguchi Hiroto , Fujii Satoshi , Kobune Masayoshi , Fukudo Masahide , Toda Takaki 
Published: December 2023

Abstract
Background
Long-term care issues, specifically metabolic bone disorders, are a concern for people living with human immunodeficiency virus (PLWH) who undergo life-long antiretroviral therapy (ART). Previous clinical trials with denosumab, an anti-RANKL antibody inhibitor, have revealed its effectiveness in increasing bone mineral density (BMD) in patients with osteoporosis. However, there are limited data on adherence and effectiveness of denosumab treatment for osteoporosis in PLWH. Hence, this study aimed to investigate the adherence and effectiveness of denosumab treatment for osteoporosis in Japanese PLWH.

Methods
This study is a retrospective exploratory analysis of 29 Japanese PLWH who initiated denosumab treatment for osteoporosis, between 2013 and 2021. The study included patients who received at least one dose of denosumab every 6 months. Adherence and persistence were defined as receiving two consecutive injections of denosumab 6 months ± 4 weeks apart and 6 months + 8 weeks apart, respectively. The primary outcome measure of the study was the adherence of denosumab treatment for 24 months. The secondary outcome measures included treatment persistence and BMD. The period after January 2020 was defined as the coronavirus disease 2019 (COVID-19) pandemic period, and its impact on adherence was investigated.

Results
The treatment adherence rates at 12 and 24 months were 89.7% and 60.7%, respectively. By contrast, the treatment persistence at 12 and 24 months was 100% and 85.7%, respectively. More patients in the group who initiated denosumab treatment after the COVID-19 pandemic reached non-adherence than in the group who initiated denosumab treatment before the pandemic. BMD at the lumbar spine and femoral neck significantly increased compared to that at baseline, with median percentage changes of 8.7% (p < 0.001) and 3.5% (p = 0.001), respectively.

Conclusions
The results showed that patients in the study had a high rate of non-adherence but a lower rate of non-persistence. Additionally, PLWH on ongoing ART experienced increased BMD with denosumab treatment. This study provides an opportunity to improve future strategies for denosumab treatment in the Japanese PLWH.
Effect of 1,25-dihydroxyvitamin D3-glycosides on postpartum health, uterine involution and litter performance of sows in a free farrowing system
Authors: Jahn Laura , Grahofer Alexander 
Published: December 2023

Abstract
Background
Vitamin D is essential for the reproductive efficiency in animals. There are indications that 1,25-vitD influenced the farrowing process and thus can decrease postpartum health problems. Therefore, the aim of this study was to investigate the effect of 1,25-vitD on postpartum health of the sow and uterine involution as well as the litter performance.

Results
The rectal body temperature in the 1,25-vitD group was significantly (p < 0.05) lower during the first five days after farrowing compared to the negative control group (D1: 38.6 vs. 38.9 °C; D2: 38.5 vs. 38.7 °C; D3: 38.4 vs. 38.7 °C; D4: 38.4 vs. 38.6 °C; D5: 38.5 vs. 38.9 °C). Although there was no difference between the live born piglets after farrowing, a significant higher number of piglets at day 7 and at weaning (Dw) was detected in the 1,25-vitD group compared to the control group (D7: 14.1 ± 0.9 vs. 13.4 ± 1.0, p = 0.002; Dw: 14.0 ± 0.9 vs. 13.4 ± 1.0, p = 0.02). Furthermore, the litter weight gain was significantly higher in the 1,25-vitD group when compared to the control group (94.3 vs. 86.4 kg; p = 0.045), and the weight loss of the sows was significantly lower (52 vs. 59 kg; p = 0.03). No differences in other parameter were detected.

Conclusion
This study showed a positive effect of 1,25-vitD on the body temperature, the litter performance and the body condition of the sows during lactation in comparison with the negative control group. However, more studies are needed to describe the mechanism of 1,25-vitD in detail.
Protocol for a randomised controlled feasibility trial of parent-delivered early language intervention for children with Down syndrome (PACT-DS)
Authors: Burgoyne Kelly , Pagnamenta Emma , Hartwell Kirstie , Stojanovik Vesna 
Published: December 2023

Abstract
Background
Down syndrome is the most common genetic cause of intellectual disability, affecting 700–800 babies annually in the UK (Wu J, Morris J, Eur J Hum Genet 21:1016–9, 2013). Children with Down syndrome have difficulties developing language skills. These difficulties can have long-term negative consequences for all aspects of their lives including social development, education and employment opportunities, and emotional wellbeing and mental health (Irwin LG et. al 2007). These aspects all have the potential to be improved through targeted early language intervention. Parents and Children Together (PACT) is a parent-delivered early language teaching programme for typically developing pre-school children at risk of language delays. A previous project (Burgoyne K, J Child Psychol Psychiatry 59(5):545–55, 2018) showed that PACT leads to improvements in children’s language and early literacy skills. Our team has worked closely with six families to adapt PACT for children with Down syndrome. The aim of the current study is to conduct a feasibility randomised controlled trial (RCT) to evaluate the feasibility of a definitive RCT and explore initial evidence of the adapted programme’s potential to support children’s language and literacy development.

Method
This is a two-arm feasibility randomised controlled trial in which children will be randomly allocated to either a PACT-DS group or to a waiting control group (who will receive intervention at the end of the project). We aim to recruit 28–30 children with Down syndrome (aged 3–6 years) and their parents/caregivers to take part. The PACT-DS group will be trained to deliver PACT-DS every day (20 min a day; 5 days a week) to their child over 30 weeks. We will collect data using assessments of child language and early literacy, measures of parent wellbeing, qualitative surveys and interviews, and monitoring data to explore trial feasibility (including recruitment and retention of families and adherence and acceptability of intervention) and cost and benefits. Data will be collected before intervention, immediately after the 30-week intervention programme, and 6 months after intervention ends. Clear progression criteria will be used to assess suitability for a definitive trial.

Discussion
This study represents initial steps in developing a definitive trial of the PACT-DS programme and will add to the limited evidence base on early language intervention for children with Down syndrome. This programme of research has the potential to make significant advancements in early language intervention research and practice for this group.

Trial registration
The trial is registered with the ISRCTN registry: study ID ISRCTN63251282. Registered on 14 July 2023.
Lessons learnt in the first year of an Australian pediatric cardio oncology clinic
Authors: Toro Claudia , Felmingham Ben , Jhadav Mangesh , Celermajer David S. , La Gerche Andre , O’Sullivan John , Kumar Sanjeev , Mateos Marion K. , Fulbright Joy , Govender Dinisha , Collier Lane , Cheung Michael , Eisenstat David D. , Lange Peter W. , Ayer Julian , Elliott David A. , Conyers Rachel 
Published: December 2023

Abstract
Background
Modern oncological therapies together with chemotherapy and radiotherapy have broadened the agents that can cause cardiac sequelae, which can manifest for pediatric oncology patients while on active treatment. Recommendations for high-risk patients who should be monitored in a pediatric cardio-oncology clinic have previously been developed by expert Delphi consensus by our group. In 2022 we opened our first multidisciplinary pediatric cardio-oncology clinic adhering to these recommendations in surveillance and management.

Objectives
Our pediatric cardio-oncology clinic aimed to:
(i) Document cardiovascular toxicities observed within a pediatric cardio-oncology clinic and.
(ii) Evaluate the applicability of the Australian and New Zealand Pediatric Cardio-Oncology recommendations.

Methods
Monthly multidisciplinary cardio-oncology clinics were conducted in an Australian tertiary pediatric hospital. Structured standardised approaches to assessment were built into the electronic medical record (EMR). All patients underwent baseline echocardiogram and electrocardiogram assessment together with vital signs in conjunction with standard history and examination.

Results
Nineteen (54%) individuals had a documented cardiovascular toxicity or pre-existing risk factor prior to referral. The two most common cardiovascular toxicities documented during clinic review included Left Ventricular Dysfunction (LVD) and hypertension. Of note 3 (8.1%) patients had CTCAE grade III LVD. An additional 10 (27%) patients reviewed in clinic had CTCAE grade I hypertension. None of these patients had hypertension noted within their referral. Cascade testing for cardiac history was warranted in 2 (5.4%) of patients.

Conclusions
Pediatric cardio-oncology clinics are likely beneficial to documenting previously unrecognised cardiotoxicity and relevant cardiac family histories, whilst providing an opportunity to address lifestyle risk factors.
Hyposidra talaca NPV (HytaNPV): a potential baculovirus for efficient control of the black inch worm, Hyposidra talaca Walker (Lepidoptera: Geometridae), a major pest of tea Camellia sinensis (Ericales: Theaceae (L.) O. Kuntze)
Authors: Deka Bhabesh , Babu Azariah , Sarkar Suman , Kuriakose Boney , Thomas George 
Published: December 2023

AbstractBackgroundThe black inch worm (BIW),Hyposidra talacaWalker (Lepidoptera: Geometridae), is a pest that defoliates tea leaves in India, posing a significant threat to the tea industry. Nucleopolyhedrovirus (NPV) is capable of infecting larvae of this species, which has raised the possibility of its use as a biocontrol agent.ResultsRearing larvae in a semi-synthetic artificial diet produced healthy adults, which is sufficient for mass culture ofH. talacato support one of the IPM components using baculovirus. In artificial diets, the NPV was evaluated for its insecticidal activity againstH. talaca. The bioassay findings of inoculatedH. talacanucleopolyhedrovirus virus (HytaNPV) at various concentrations showed that it was effective in killing the BIW. Purifiedpolyhedral inclusion bodies(PIBs) were estimated to a concentration of 1 × 1010PIBs per ml by mixing with water, and various concentrations of 0.25, 0.5, 1, 2, 5, 7.5, 10 ml/l were evaluated against BIW. Both laboratory and field studies revealed that HytaNPV is an eco-friendly and ecologically safe agent for controlling BIW. Besides no residue was estimated in made tea after the seventh day of exposure, and it is nontoxic to non-target species.ConclusionIt was found that NPV is environmentally beneficial for the control of pests on tea plants and in production of pesticide-free tea. Tea ecosystems can reduce their reliance on conventional insecticides by using HytaNPV as an alternative bio-insecticide.
Rendezvous intervention using combined surgical carotid endarterectomy followed by endovascular thrombectomy in patients with acute tandem occlusions: a proof-of-concept experience at a tertiary care center
Authors: Diel Norma J. , Gerner Stefan T. , Alhaj Omar Omar , Kalder Johannes , Manz Enikö , Keschenau Paula R. , Struffert Tobias , Brueckner Thomas , Huttner Hagen B. , Doeppner Thorsten R. 
Published: December 2023

Abstract
Background
Endovascular thrombectomy (EVT) is highly effective in acute stroke patients with intracranial large vessel occlusion (LVO), however, presence of concomitant cervical occlusion of the internal carotid artery (ICA) may limit the endovascular access. This study describes feasibility and efficacy of a surgical carotid access (cutdown) to perform interdisciplinary recanalization therapy including carotid endarterectomy (CEA) followed by EVT for recanalization of intracranial LVO in stroke patients with tandem occlusions.

Methods
We identified stroke patients with tandem occlusions who underwent a combined surgical-endovascular approach over a 5-year period. Surgical cutdown was provided by a cardiovascular surgery team at the angio-suite followed by EVT performed by the neuroradiological team. Demographics, stroke characteristics, treatments including antithrombotic management, procedure times, and clinical follow-up were assessed.

Results
Four patients with acute stroke because of tandem occlusions received CEA followed by EVT (two patients after frustrating femoral catheterization, two as first-line approach). Successful recanalization (TICI ≥ 2b) via endovascular thrombectomy was achieved in all patients at a median of 28 min after successful surgical CEA. Intraprocedural complication was observed in one case (25%; i.e. ICA dissection).

Conclusions
This small study provides evidence that a combined interdisciplinary approach of CEA followed by EVT in the angio-suite in acute stroke patients with tandem occlusions is a feasible procedure in patients otherwise not accessible to endovascular recanalizing therapy and, therefore, high likelihood of developing large hemispheric infarction. Prospective data are warranted to identify patients who benefit from this combined approach as first-line therapy.
Distribution of high- and low-risk human papillomavirus genotypes and their prophylactic vaccination coverage among West African women: systematic review
Authors: Ouedraogo Rogomenoma Alice , Kande Ali , Nadembega Wendyam Marie Christelle , Ouermi Djeneba , Zohoncon Théodora Mahoukèdè , Djigma Florencia Wendkuuni , Ouedraogo Charlemagne Marie Ragnag-Newende , Lompo Olga Mélanie , Simpore Jacques 
Published: December 2023

Abstract
Introduction
The second most deadly gynecological cancer worldwide, cervical cancer is steadily on the rise in sub-Saharan Africa, while vaccination programs are struggling to get off the ground. This systematic review’s aim was to assess the prevalence and distribution of high- and low-risk HPV genotypes in West African women.

Methods
Original studies were retrieved from PubMed/Medline, Embase, Scopus, Google Scholar, and Science Direct. In these studies, Human papillomavirus (HPV) DNA was assessed in cervical samples by polymerase chain reaction (PCR), Hybrid capture, and sequencing. The quality of the articles was assessed and the results were extracted and reviewed.

Results
Thirty-nine studies from 10 West African countries were included for the systematic review including 30 for the pooled analysis. From an overall of 17358 participants, 5126 of whom were infected with at least one HPV genotype, the systematic review showed a prevalence varying from 8.9% to 81.8% in the general population. In contrast, the pooled prevalence of infection was 28.6% (n = 3890; 95% CI 27.85–29.38), and HPV-52 (13.3%), HPV-56 (9.3%), and HPV-35 (8.2) were the most frequent. Quadrivalent and nonavalent vaccines covered 18.2% and 55.8% of identified genotypes respectively.

Conclusion
Faced with this growing public health challenge in West Africa, it would be necessary for all its countries to have reliable data on HPV infection and to introduce the nonavalent vaccine. A study of the genotypic distribution of HPV in high-grade precancerous lesions and cervical cancer would be very useful in West Africa.
Sarcopenia in Egypt: epidemiology of sarcopenia risk among older adults presenting with fragility fractures—an initiative by the Egyptian Academy of Bone Health
Authors: El Miedany Yasser , El Gaafary Maha , Gadallah Naglaa , Elwakil Walaa , Hassan Waleed , Fathi Nihal , Abu-Zaid Mohammed Hassan , Tabra Samar abd Alhamed , Shalaby Radwa H. , Mahran Safaa 
Published: December 2023

Abstract
Purpose
(1) This was a multi-center, cross-sectional, observational study. Both old men and postmenopausal women over 50 years old who were admitted with an osteoporotic fracture (whether hip fracture or major osteoporosis) were consecutively recruited for this work and managed under the Fracture Liaison Service. All the patients were assessed for their sarcopenia risk (SARC-F), fracture risk (FRAX), and fall risk (FRAS) as well as functional disability (HAQ). The aim was to assess the prevalence of sarcopenia risk among older adult Egyptians presenting with fragility fractures. (2) To identify the relation between sarcopenia risk with the risk of falling as well as sustaining a fragility fracture.

Results
Two hundred and thirty-six patients (69 males, 167 females) were included in this work. The mean age was 70.1 (SD = 9.2) years. The prevalence of sarcopenia was 69.7%. The sarcopenia risk score was positively correlated with the FRAX score (p = 0.01). The prevalence of high sarcopenia risk was 78% of the patients presenting with a high 10-year probability of major osteoporosis fracture as well as a 10-year probability of hip fracture. The sarcopenia risk score was positively correlated with the increased fall risk (p = 0.01) as scored by the FRAS scale. There was a significant relation (p < 0.05) between the functional disability score and the SARC-F score. This was persistent when assessed in relation to fall risk.

Conclusion
This study highlighted the high sarcopenia risk in the patients presenting with fragility fractures. Identification of patients at increased risk of sarcopenia should be a component of the standard practice.