bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m
Authors: Yang Ruoting , Gautam Aarti , Hammamieh Rasha , Roach Robert C. , Beidleman Beth A. 
Published: January 2025

IntroductionAcute mountain sickness (AMS) is a common altitude illness that occurs when individuals rapidly ascend to altitudes ≥2,500 m without proper acclimatization. Genetic and genomic factors can contribute to the development of AMS or predispose individuals to susceptibility. This study aimed to investigate differential gene regulation and biological pathways to diagnose AMS from high-altitude (HA; 4,300 m) blood samples and predict AMS-susceptible (AMS+) and AMS-resistant (AMS─) individuals from sea-level (SL; 50 m) blood samples.MethodsTwo independent cohorts were used to ensure the robustness of the findings. Blood samples were collected from participants at SL and HA. RNA sequencing was employed to profile gene expression. Differential expression analysis and pathway enrichment were performed to uncover transcriptomic signatures associated with AMS. Biomarker panels were developed for diagnostic and predictive purposes.ResultsAt HA, hemoglobin-related genes (HBA1, HBA2, and HBB) and phosphodiesterase 5A (PDE5A) emerged as key differentiators between AMS+ and AMS− individuals. The cAMP response element-binding protein (CREB) pathway exhibited contrasting regulatory patterns at SL and HA, reflecting potential adaptation mechanisms to hypoxic conditions. Diagnostic and predictive biomarker panels were proposed based on the identified transcriptomic signatures, demonstrating strong potential for distinguishing AMS+ from AMS− individuals.DiscussionThe findings highlight the importance of hemoglobin-related genes and the CREB pathway in AMS susceptibility and adaptation to hypoxia. The differential regulation of these pathways provides novel insights into the biological mechanisms underlying AMS. The proposed biomarker panels offer promising avenues for the early diagnosis and prediction of AMS risk, which could enhance preventive and therapeutic strategies.
Implicit learning of unfamiliar tone sandhi patterns in lexical recognition
Authors: Zou Ting , Luo Xinbing 
Published: January 2025

IntroductionThis study investigates whether unfamiliar tone sandhi patterns in Tianjin Mandarin can be implicitly learned through an artificial language learning experiment, and if the acquired knowledge is rule-based and generalizable.MethodsParticipants were trained to learn monosyllabic words and disyllabic phrases with their attention focused on a word-order rule, while unknowingly being exposed to unfamiliar tone sandhi patterns. A judgement test with trial-to-trial confidence ratings was conducted to assess the learning outcomes and participants’ awareness.ResultsResults revealed significantly above-chance performance on tone sandhi patterns for learned phrases. This learning effect was generalized to unseen phrases made up of familiar words, but not to phrases with new words, indicating a degree of abstraction across instances, though the learning is not fully rule-based. The confidence rating results suggest that participants were unaware of the structural sandhi knowledge, but the reaction time data of the judgement test indicate that the sandhi knowledge was learned with awareness at the level of noticing.DiscussionThe results have been discussed in light of theories of implicit learning and the findings of previous research on phonological learning.
Linking workplace digitalization to work engagement: evidence from China public sector organizations
Authors: Zhan Xiaohui , Xie Shenghua 
Published: January 2025

PurposeThe construction of “Digital Government” has greatly facilitated the workplace digitalization in the public sectors of China. Workplace digitalization has become a pervasive phenomenon in modern organizations, including the public sector. Existing research on the impact of workplace digitalization on individual behavior has yielded conflicting results, making the impact of workplace digitalization on employee work engagement remains a subject of debate and investigation. Based on the transactional theory of stress, this article aims to examine how workplace digitalization influences government employees’ work engagement through different appraisals (i.e., challenge and threat) and the moderating role of a personal trait (i.e., digital literacy).MethodsStructured questionnaires and a three-wave research design were used to collect data. A total of 290 employees from public organizations in Guangdong Province, in China, participated in the study. SPSS and MPLUS were used to analyze the data using the latest bootstrapping and process macro techniques.ResultsThe results show that workplace digitalization can produce both beneficial and detrimental impacts on work engagement of government employees via challenge and threat appraisals, respectively. The digital literacy of government employees was confirmed to moderate the impacts of perceived workplace digitalization on stress appraisals (i.e., challenge and threat).ConclusionOur study proposes a theoretical framework that explain the mixed impacts of workplace digitalization on government employees’ work engagement via challenge and threat appraisals. It also offers practical suggestions to public sector and managers on how to balance the challenge and threat aspects of digitalization in the workplace.
The effect of sleep quality on learning engagement of junior high school students: the moderating role of mental health
Authors: Xu Zhenguo , Niu Menghui , Du Wenxiu , Dang Tongtong 
Published: January 2025

IntroductionA good quality of sleep is not only an important guarantee for students’ academic life, but also an important founding condition for their physical and mental health development. The study aims to explore the relationship between sleep quality and students’ learning engagement, and to deeply analyze the moderating role played by mental health.MethodsA questionnaire survey was conducted among some junior high school students in Rizhao City, Shandong Province for the research.ResultsThe results show that: (1) The main effect of sleep quality on learning engagement is significant (β = 0.476, t = 1.829, p &lt; 0.001), specifically, the better the sleep quality, the higher the students’ learning engagement. (2) The influence of sleep quality on learning engagement is moderated by mental health (β = –0.850, t = -2.652, p = 0.006), that is to say, the influence of sleep quality on learning engagement is more significant for students with poor mental health, and mentally healthy students can effectively alleviate the negative impact of sleep problems on their learning engagement.DiscussionResearch shows the significance of good sleep quality and mental health for students’ learning. The research results provide empirical evidence for schools, families, and policy makers to improve students’ academic achievement and mental health.
The role of prosocial tendencies in the relationships between gratitude, perceived social support, and psychological well-being among Chinese university students: a structural equation modeling approach
Authors: Man Xu , Jing Zhang 
Published: January 2025

IntroductionThis study explores the relationships among gratitude, perceived social support, prosocial tendencies, and psychological well-being (PWB) in Chinese university students. Despite growing interest in these constructs, the mechanisms through which gratitude and social support influence PWB remain underexplored, particularly in collectivist cultural contexts where social harmony and interdependence are prioritized.MethodsData were collected from 703 Chinese university students using validated instruments measuring gratitude, perceived social support, prosocial tendencies, and psychological well-being. Structural equation modeling (SEM) was employed to test the direct and indirect effects of gratitude and social support on PWB, with prosocial tendencies modeled as a mediating higher-order factor. Multi-group SEM analysis was conducted to examine gender invariance.ResultsGratitude and perceived social support significantly predicted PWB, both directly and indirectly through prosocial tendencies. Gratitude had a strong positive effect on prosocial tendencies (β = 0.412, p &lt; 0.001), which, in turn, significantly contributed to PWB (β = 0.465, p &lt; 0.001). Similarly, perceived social support positively influenced prosocial tendencies (β = 0.375, p &lt; 0.001) and PWB (β = 0.253, p &lt; 0.05). Mediation analysis confirmed that prosocial tendencies partially mediated these relationships. Multi-group SEM analysis revealed structural invariance across gender.DiscussionThe findings underscore the cultural relevance of gratitude and social support within Chinese society, emphasizing the role of collectivist values in fostering PWB. Practical implications include implementing gratitude-focused interventions and enhancing peer support systems within university mental health programs to promote resilience and well-being among students.
Sleep as a mediator between chronic diseases and depression: a NHANES study (2005–2018)
Authors: Tan Ming , Zhao Haihong , Nie Ruya , Deng Pingping , Wang Cuixiao 
Published: January 2025

ObjectiveThis article investigates the relationship between common chronic diseases and depression among US adults and examines the mediating role of sleep in this relationship, using a cross-sectional study to offer recommendations for depression prevention.MethodsThis study analyzed data from 10,710 participants collected from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. Logistic regression, subgroup analysis, restricted cubic spline (RCS) analysis, and mediation analysis were employed to explore the relationship between common chronic diseases and depression, and the mediating role of sleep.ResultsThe adjusted model indicated that stroke (OR = 1.712, 95% CI: 1.399, 2.103), heart disease (OR = 1.419, 95% CI: 1.262, 1.598), diabetes (OR = 1.243, 95% CI: 1.116, 1.386), and hypertension (OR = 1.249, 95% CI: 1.160, 1.346) were associated with an increased probability of depression. Additionally, trouble sleeping (OR = 2.059, 95% CI: 1.790, 2.375) was associated with an increased probability of depression, while sleep hours (OR = 0.867, 95% CI: 0.846, 0.888) may decrease this probability. RCS analysis showed a non-linear relationship between sleep hours and the risk of depression. The final mediation analysis showed that trouble sleeping mediated 3.66% of the effect of stroke, 12.68% of heart disease, and 17.76% of diabetes on depression. Furthermore, trouble sleeping mediated 11.07% of the impact of hypertension on depression, while sleep hours mediated 5.36% of this impact.ConclusionChronic diseases and sleep problems may increase the likelihood of depression among U.S. adults, with sleep serving as a mediator between chronic diseases and depression.
The impact of social exclusion on experiential sports consumption: the chain mediating roles of loneliness and the need for social connection
Authors: Li Chenya , Qu Weihua 
Published: January 2025

IntroductionWith the advancement of the social economy, sports consumption has shifted from traditional material-based purchases to experiential sports consumption, emphasizing psychological engagement and emotional fulfillment. However, the psychological mechanisms behind experiential sports consumption remain underexplored, especially in the context of social exclusion.MethodsThis study is grounded in social exclusion theory, constructing a conceptual model where social exclusion is the independent variable, experiential sports consumption intention is the dependent variable, and loneliness and the need for social connection serve as mediators. A survey was conducted with 415 valid responses, and data were analyzed using structural equation modeling and the Bootstrap method to examine the relationships among the variables.ResultsThe findings indicate that social exclusion significantly and positively predicts the intention to engage in experiential sports consumption. It also has a significant positive effect on loneliness and the need for social connection. However, loneliness does not mediate the relationship between social exclusion and experiential sports consumption intention, while the need for social connection does. Furthermore, a chain mediation effect exists between loneliness and the need for social connection in the relationship between social exclusion and experiential sports consumption intention.DiscussionThese results suggest that sports organizations and enterprises should design socially engaging activities that strengthen social connections and alleviate feelings of exclusion. This study enriches the theoretical understanding of social exclusion and its impact on experiential sports consumption, providing practical insights for enhancing social inclusion through sports.
Immigration modulates audiovisual emotional processing in adults: is this really an influence of the host culture?
Authors: Nakamura Anna K. , Yamamoto Hisako W. , Takagi Sachiko , Matsuda Tetsuya , Okada Hiroyuki , Ishiguro Chiaki , Tanaka Akihiro 
Published: January 2025

IntroductionIndividuals from Western cultures rely on facial expressions during the audiovisual emotional processing of faces and voices. In contrast, those from East-Asian cultures rely more on voices. This study aimed to investigate whether immigrants adopt the tendency of the host culture or whether common features of migration produce a similar modification regardless of the destination.MethodsWe examined how immigrants from Western countries to Japan perceive emotional expressions from faces and voices using MRI scanning.ResultsImmigrants behaviorally exhibited a decrease in the influence of emotions in voices with a longer stay in Japan. Additionally, immigrants with a longer stay showed a higher response in the posterior superior temporal gyrus, a brain region associated with audiovisual emotional integration, when processing emotionally congruent faces and voices.DiscussionThese modifications imply that immigrants from Western cultures tend to rely even less on voices, in contrast to the tendency of voice-dominance observed in native Japanese people. This change may be explained by the decreased focus on prosodic aspects of voices during second language acquisition. The current and further exploration will aid in the better adaptation of immigrants to a new cultural society.
Maternal singing and speech have beneficial effects on preterm infant’s general movements at term equivalent age and at 3 months: an RCT
Authors: Filippa Manuela , Filippa Gianluca , Della Casa Elisa , Berardi Alberto , Picciolini Odoardo , Meloni Sara Chiara , Lunardi Clara , Cecchi Alessandra , Sansavini Alessandra , Corvaglia Luigi , Grandjean Didier ,   EVC Group, Ferrari Fabrizio 
Published: January 2025

BackgroundGeneral Movements (GMs) are part of the spontaneous movement repertoire and assessing them helps to determine the integrity of the central nervous system in newborns. The aim of this study was to investigate the effects of maternal singing and speaking in the Neonatal Intensive Care Unit (NICU) on preterm infants’ GMs at term equivalent age and at 3 months.MethodsIn this multi-center randomized clinical trial, 56 stable preterm infants (25–32 weeks) were randomized to either an intervention group – in which mothers were asked to speak and sing to their infants for 20 min, 3 times per week, for 2 weeks – or to a control group. GMs were recorded both before and after the intervention – which took place at term equivalent age – and again at 3 months corrected age. The GMs were blindly coded based on the muted video tracks to produce both a general score and a detailed score.ResultsBefore the intervention, there were no significant differences between the two groups. The intervention wielded a significant effect on the GMs general score (p &lt; 0.05). The effect was also marginally significant for the GMs detailed score (p = 0.06). To avoid influencing outcomes, future research should control for differences in maternal engagement outside of the intervention.ConclusionLive maternal singing and speaking are fundamental human practices that, in this study, enhanced preterm infants’ general movements and potentially supported their neurobehavioral development. Integrating and supporting early vocal interaction into routine NICU care is crucial for at-risk populations.
The relationship between physical activity and career decision-making self-efficacy in Chinese college students: the mediating roles of self-control and social anxiety
Authors: Fang Yuan , Xu Tingting , Ye Maosheng , Li Changquan 
Published: January 2025

ObjectivesEnhancing career decision-making self-efficacy is an effective approach to improving university graduates' employment quality and speed. This study aims to explore the relationships among physical activity, career decision-making self-efficacy, self-control, and social anxiety to provide new perspectives and directions for enhancing university students' career decision-making self-efficacy.MethodsWithin the framework of this research endeavor, a cohort of 1,955 university students (N = 1,955) from 14 universities distributed throughout China was surveyed. The initial data was entered and stored by means of Microsoft Excel. Subsequently, SPSS version 26.0 was employed to execute a comprehensive set of statistical analyses on the data, including descriptive statistics, a normality test, a reliability test, an exploratory factor analysis (aimed at addressing common method bias), a correlation test, and a regression analysis. In the present study, a structural equation model was formulated via the utilization of AMOS 24.0 software, and the Bootstrap approach was implemented. A total of 5,000 samples were randomly drawn for the purpose of validating the research hypotheses, with the determination being based on whether the 95% confidence interval encompassed the value of 0.Results(1) Physical activity was found to positively predict career decision-making self-efficacy, as evidenced by (Estimate = 0.590, p &lt; 0.001). (2) Self-control was demonstrated to play a mediating role in the connection between physical activity and career decision-making self-efficacy, with the effect indicated by (Estimate = 0.075, 95%CI(0.042, 0.113)]. (3) Social anxiety was likewise shown to assume a mediating role within the relationship between physical activity and career decision-making self-efficacy, as manifested by [Estimate = 0.009, 95%CI(0.002, 0.020)]. (4) A chain mediating effect was observed between physical activity and career decision-making self-efficacy for the combination of self-control and social anxiety, with [Estimate = 0.032, 95%CI(0.008, 0.057)].ConclusionThese findings provided significant theoretical support for physical activity as an effective means to enhance university students' career decision-making self-efficacy and offered references for designing sports activity programs. Furthermore, this study offered new perspectives and directions for understanding and enhancing university students' career decision-making self-efficacy.
Assessment of clinical prognosis in autoimmune encephalitis: Girona score
Authors: Álvarez Bravo Gary , Guglielmini Giuseppe , Quiroga Varela Ana , Boix Lago Almudena , Gifreu Fraixinó Ariadna , Urso Daniele , Logroscino Giancarlo , Ramió-Torrentà Lluís 
Published: January 2025

BackgroundThe assessment of clinical prognosis in autoimmune encephalitis: Girona (ACPE-Gi) score is a scale for evaluating the severity in the acute phase of autoimmune encephalitis (AE) and predicting the risk of disability at 3 months, measured by modified Rankin scale (mRS).MethodsPatients were strictly diagnosed with AE according to the current criteria between 1 January 2009 to 31 March 2023 at the University Hospital Dr. Josep Trueta of Girona, Catalonia, Spain. ACPE-Gi score included 14 items, and every item was scored from 0 to 3, depending on their severity with a sum ranging from 0 to 41.ResultsACPE-Gi score measured the severity in the acute phase and grouped the patients into three groups: mild (&lt;8; 32%), moderate (8 to 15; 60%), and severe (&gt;15; 8%). We found that the third group had a higher risk of disability compared with the first group (p = 0.035). We identified that the mean initial score was significantly higher in the group of patients who had higher mRS at 3 months compared to that in the group of patients who had a mild to moderate disability level (mRS ≤ 2) at 3 months (p = 0.023). In addition, autonomic symptoms and mental status impairment demonstrated to be independent risk factors to predict disability (p &lt; 0.05).ConclusionsThe ACPE-Gi score seems to be a reliable scale for comprehensively evaluating the severity of AE in the acute phase and predicting the risk of disability at 3 months. Dysautonomia and altered mental status predict a poorer prognosis in patients with AE.
Adult HIV/AIDS patients are more likely to experience anxiety symptoms
Authors: Abdu Zakir , Belayneh Wondwossen , Dule Aman , Alemu Solomon Seyife , Wedajo Lema Fikadu , Hajure Mohammedamin , Tesfaye Gebremeskel Mulatu , Workneh Yadeta Alemayehu , Gezimu Wubishet , Adem Hussen Mustefa , Tefera Bilisumamulifna , Habib Sadik 
Published: January 2025

BackgroundAmong various mental disorders, anxiety disorder is commonly reported in HIV-positive individuals. Compared to the general population, people living with HIV/AIDS exhibit a higher prevalence of anxiety, with an estimated figure of 68.2% versus 29% in the general population. However, there is a scarcity of studies on the prevalence and associated factors of anxiety among people living with HIV/AIDS in Ethiopia.MethodAn institution-based cross-sectional study was conducted among 320 participants at Gambella General Hospital. The Beck Anxiety Inventory (BAI) scale, Fagerström Test for Nicotine Dependence (FTND), Severity of Dependence Scale (SDS), and the Alcohol Use Disorder Identification Test (AUDIT) were used to collect the data. Data analysis was performed using SPSS version 25. Bivariate and multivariable logistic regressions were employed to identify independently associated variables, and statistical significance was determined at a p-value &lt;0.05.ResultsOut of a total of 323 samples, 320 respondents completed all items, resulting in a response rate of 99.07%. The results showed that 28.4% (95% CI = 23.2–33.9) of participants had anxiety. Factors such as being aged 25 to 40 years, having seen a counselor, HIV disclosure, alcohol use disorders, and perceived high stigma were significantly associated with anxiety in people living with HIV (PLWH).ConclusionIn the study area, about two out of every seven people living with HIV/AIDS experienced anxiety symptoms. Factors such as being aged 25 to 40 years, having seen a counselor, HIV disclosure, alcohol use disorders, and perceived high stigma were significantly associated with anxiety in this population. Based on these findings, timely intervention is recommended to enhance the overall well-being and quality of life for people living with HIV (PLWH), leading to better health outcomes, reducing the burden of mental health issues, and supporting more holistic, patient-centered care.