bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI PROGRAM INDONESIA PINTAR (STUDI KASUS DI SEKOLAH DASAR NEGERI 117 PEKANBARU)
Authors: Romanti Romanti , Aguswan Aguswan , Ferizko Adia 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis implementasi program indonesia pintar (studi kasus di sekolah dasar negeri 117 pekanbaru) dengan metode penelitian kualitatif. Menggunakan instrument penelitian observasi, wawancara dan dokumentasi. Teori yang digunakan adalah menurut Menurut Menurut Edward III dalam Dwiyanto, 2017: 31 dengan indikator sebagai berikut: Komunikasi, Sumber Daya, Disposisi dan Struktur Birokrasi.Hasil penelitian implementasi program indonesia pintar (Studi Kasus di Sekolah Dasar Negeri 117 Pekanbaru) sudah dilaksanakan oleh stakeholder terkait yakni Dinas Pendidikan dan Sekolah Dasar itu sendiri dengan melakukan koordinasi dan rapat kerja serta sosialisasi terkait dengan keberadaan program agar dapat diberikan kepada siswa sekolah dasar dengan mekanisme dan ketentuan yang berlaku namun masih ada kekurangan pada pada aspek sumber daya yakni anggaran yang belum memadai sehingga target penerimaan Bantuan Program Indonesia Pintar Sekolah Dasar (SD) setiap tahunnya mengalami kenaikan dan penurunan jumlah sehingga memungkinkan masyarakat untuk tidak mendapatkan bantuan lagi.
Engaging EFL Young Learners through Task-based Teaching with Character Education-enriched Materials
Authors: Inawati Iin , Suherdi Didi , Purnawarman Pupung 
Published: January 2024

This study aimed to investigate how the Task-Based Teaching Materials with Character Education Values (TBTMCEV) was implemented in teaching speaking in kindergarten context. The studentsâ€™ speaking performance was also explored in this study. An exploratory case study research design was used in this study while the participants were two teachers and 14 students whose ages range between 5 and 6 years old. The data were gleaned from classroom observations, observation rating scale, and documents.Â The data analysis results that teaching speaking to kindergarten students in which Task-Based Teaching Materials with Character Education Values was implemented covers three stages including preparation, core activity and follow up as proposed by Cameron. The other result from data analysis shows that the students can produce three kinds of speaking performance during the teaching learning process, these include: naming objects, producing simple sentences, and getting involved in a dialog. The results lead to the conclusion that all of the students had chance to be actively involved in a dialog. It indicates that TBMCEV apparently could overcome resistance to the target language and create a need for speaking.Â Penelitian ini bertujuan untuk menyelidiki bagaimana Bahan Ajar Berbasis Tugas dengan Nilai Pendidikan Karakter (Task-Based Teaching Materials with Character Education Values/TBTMCEV)) diimplementasikan dalam pengajaran berbicara dalam konteks taman kanak-kanak. Kemampuan berbicara siswa juga dieksplorasi dalam penelitian ini. Desain penelitian studi kasus eksplorasi digunakan dalam penelitian ini dengan partisipan dua guru dan 14 siswa yang berusia antara 5 dan 6 tahun. Data diperoleh dari observasi kelas, skala penilaian observasi, dan dokumen. Hasil analisis data menunjukkan bahwa pembelajaran berbicara pada siswa taman kanak-kanak yang mengimplementasikan Materi Ajar Berbasis Tugas dengan Nilai Pendidikan Karakter meliputi tiga tahap yaitu persiapan, kegiatan inti dan tindak lanjut seperti yang dikemukakan oleh Cameron. Hasil lain dari analisis data menunjukkan bahwa siswa dapat menghasilkan tiga jenis kemampuan berbicara selama proses belajar mengajar, yaitu: menamai objek, memproduksi kalimat sederhana, dan terlibat dalam dialog. Hasil dari penelitian ini mengarah pada kesimpulan bahwa semua siswa memiliki kesempatan untuk terlibat aktif dalam dialog. Hal ini menunjukkan bahwa bahan ajar ini ternyata dapat mengatasi penolakan terhadap bahasa target dan menciptakan kebutuhan untuk berbicara.
Fermentative processes for the upcycling of xylose to xylitol by immobilized cells of Pichia fermentans WC1507
Authors: Ranieri Raffaella , Candeliere Francesco , Moreno-García Jaime , Mauricio Juan Carlos , Rossi Maddalena , Raimondi Stefano , Amaretti Alberto 
Published: January 2024

Xylitol is a pentose-polyol widely applied in the food and pharmaceutical industry. It can be produced from lignocellulosic biomass, valorizing second-generation feedstocks. Biotechnological production of xylitol requires scalable solutions suitable for industrial scale processes. Immobilized-cells systems offer numerous advantages. Although fungal pellet carriers have gained attention, their application in xylitol production remains unexplored. In this study, the yeast strain P. fermentans WC 1507 was employed for xylitol production. The optimal conditions were observed with free-cell cultures at pH above 3.5, low oxygenation, and medium containing (NH4)2SO4 and yeast extract as nitrogen sources (xylitol titer 79.4 g/L, YP/S 66.3%, and volumetric productivity 1.3 g/L/h). Yeast cells were immobilized using inactive Aspergillus oryzae pellet mycelial carrier (MC) and alginate beads (AB) and were tested in flasks over three consecutive production runs. Additionally, the effect of a 0.2% w/v alginate layer, coating the outer surface of the carriers (cMC and cAB, respectively), was examined. While YP/S values observed with both immobilized and free cells were similar, the immobilized cells exhibited lower final xylitol titer and volumetric productivity, likely due to mass transfer limitations. AB and cAB outperformed MC and cMC. The uncoated AB carriers were tested in a laboratory-scale airlift bioreactor, which demonstrated a progressive increase in xylitol production in a repeated batch process: in the third run, a xylitol titer of 63.0 g/L, YP/S of 61.5%, and volumetric productivity of 0.52 g/L/h were achieved. This study confirmed P. fermentans WC 1507 as a promising strain for xylitol production in both free- and entrapped-cells systems. Considering the performance of the wild strain, a metabolic engineering intervention aiming at further improving the efficiency of xylitol production could be justified. MC and AB proved to be viable supports for cell immobilization, but additional process development is necessary to identify the optimal bioreactor configuration and fermentation conditions.
Numerical simulation of ice plugging process using multi-jacket method in nuclear power pipes
Authors: Zhang Wei , Xu Ke , Hu Ming-Lei , Liang Hui-Jie , Chen Hao , Wang Li-Qun , Feng Yong-Qiang 
Published: January 2024

Introduction: Ice plugs acts as isolate maintenance sections during pipeline repairs in nuclear power plants can effectively reduce maintenance costs, which is formed by the cooling of liquid nitrogen. The single-jacket freezing method takes a long time for the formation of ice plugs with a certain load-bearing capacity, increasing the liquid nitrogen consumption.Methods: In this study, a multiple-jacket method for the formation of ice plugs was proposed, and the numerical simulation using CFD (Computational Fluid Dynamics) was conducted. The effects of total jacket length and jacket number on freezing time and the consumption of liquid nitrogen were analyzed.Results and Discussion: Research indicated that the multiple-jacket method obtained a 11%∼15% decrease in freezing time and a 18%∼26% decrease in liquid nitrogen consumption than the single-jacket method. For the multiple-jacket method, the gap between the jackets presented a certain influence on the freezing time and liquid nitrogen consumption. As the gap between the jackets increases, there exist a small increase in the freezing time, but the liquid nitrogen consumption will be reduced by 2% to 5%.
Exploration of the hypoglycemic mechanism of Fuzhuan brick tea based on integrating global metabolomics and network pharmacology analysis
Authors: Xiang Xingliang , You Shanqin , Zeng Zhaoxiang , Xu Jinlin , Lin Yuqi , Liu Yukun , Zhang Lijun , Huang Rongzeng , Song Chengwu , Jin Shuna 
Published: January 2024

Introduction: Fuzhuan brick tea (FBT) is a worldwide popular beverage which has the appreciable potential in regulating glycometabolism. However, the reports on the hypoglycemic mechanism of FBT remain limited.Methods: In this study, the hypoglycemic effect of FBT was evaluated in a pharmacological experiment based on Kunming mice. Global metabolomics and network pharmacology were combined to discover the potential target metabolites and genes. In addition, the real-time quantitative polymerase chain reaction (RT-qPCR) analysis was performed for verification.Results: Seven potential target metabolites and six potential target genes were screened using the integrated approach. After RT-qPCR analysis, it was found that the mRNA expression of VEGFA, KDR, MAPK14, and PPARA showed significant differences between normal and diabetes mellitus mice, with a retracement after FBT treatment.Conclusion: These results indicated that the hypoglycemic effect of FBT was associated with its anti-inflammatory activities and regulation of lipid metabolism disorders. The exploration of the hypoglycemic mechanism of FBT would be meaningful for its further application and development.
ER exit in physiology and disease
Authors: Robinson Claire M. , Duggan Aislinn , Forrester Alison 
Published: January 2024

The biosynthetic secretory pathway is comprised of multiple steps, modifications and interactions that form a highly precise pathway of protein trafficking and secretion, that is essential for eukaryotic life. The general outline of this pathway is understood, however the specific mechanisms are still unclear. In the last 15 years there have been vast advancements in technology that enable us to advance our understanding of this complex and subtle pathway. Therefore, based on the strong foundation of work performed over the last 40 years, we can now build another level of understanding, using the new technologies available. The biosynthetic secretory pathway is a high precision process, that involves a number of tightly regulated steps: Protein folding and quality control, cargo selection for Endoplasmic Reticulum (ER) exit, Golgi trafficking, sorting and secretion. When deregulated it causes severe diseases that here we categorise into three main groups of aberrant secretion: decreased, excess and altered secretion. Each of these categories disrupts organ homeostasis differently, effecting extracellular matrix composition, changing signalling events, or damaging the secretory cells due to aberrant intracellular accumulation of secretory proteins. Diseases of aberrant secretion are very common, but despite this, there are few effective therapies. Here we describe ER exit sites (ERES) as key hubs for regulation of the secretory pathway, protein quality control and an integratory hub for signalling within the cell. This review also describes the challenges that will be faced in developing effective therapies, due to the specificity required of potential drug candidates and the crucial need to respect the fine equilibrium of the pathway. The development of novel tools is moving forward, and we can also use these tools to build our understanding of the acute regulation of ERES and protein trafficking. Here we review ERES regulation in context as a therapeutic strategy.
Apathy in Lewy body disease and its effects on functional impairment over time
Authors: Zhu Carolyn W. , Grossman Hillel T. , Elder Gregory A. , Rosen Howie , Sano Mary 
Published: January 2024

Background and objectivesApathy strongly affects function in Alzheimer’s disease and frontotemporal dementia, however its effect on function in Lewy Body Disease (LBD) has not been well-described. This study aims to (1) examine the prevalence and persistence of apathy in a large, national cohort of well-characterized patients with LBD, and (2) estimate the effect of apathy on function over time.MethodsStudy included 676 participants with mild cognitive impairment (MCI) or dementia in the National Alzheimer’s Coordinating Center Uniform Data Set. Participants were followed for an average of 3.4 ± 1.7 years and consistently had a primary diagnosis of LBD. Apathy was defined by clinician judgment, categorized into four mutually exclusive profiles: (1) never apathetic across all visits, (2) at least one but &lt;50% of visits with apathy (intermittent apathy), (3) ≥50% but not all visits with apathy (persistent apathy), and (4) always apathy across all visits. Dementia severity was measured by baseline Clinical Dementia Rating score. Parkinsonism was defined by the presence of bradykinesia, resting tremor, rigidity, gait, and postural instability. Functional impairment was assessed using the Functional Assessment Questionnaire (FAQ).ResultsBaseline characteristics of the sample were: average age = 72.9 ± 6.9, years of education = 15.6 ± 3.4, Mini Mental State Exam (MMSE) = 24.4 ± 5.4, Geriatric Depression Scale (GDS) = 3.8 ± 3.2, FAQ = 12.0 ± 9.1. 78.8% were male and 89% were non-Hispanic white. Prevalence of apathy increased from 54.4% at baseline to 65.5% in year 4. 77% of participants had apathy at some point during follow-up. Independent of cognitive status and parkinsonian features, FAQ was significantly higher in participants with intermittent/persistent and always apathetic than never apathetic. Annual rate of decline in FAQ was faster in participants who were always apathetic than never apathy.DiscussionIn this large national longitudinal cohort of LBD patients with cognitive impairment, apathy was strongly associated with greater functional impairment at baseline and faster rate of decline over time. The magnitude of these effects were clinically important and were observed beyond the effects on function from participants’ cognitive status and parkinsonism, highlighting the importance of specifically assessing for apathy in LBD.
The impacts of Ramadan fasting for patients with non-alcoholic fatty liver disease (NAFLD): a systematic review
Authors: Lin Xiaoxiao , Wu Guomin , Huang Jinyu 
Published: January 2024

BackgroundNumerous studies have explored the impacts of Ramadan fasting on Non-alcoholic fatty liver disease (NAFLD). Therefore, the objective of this systematic review was to analyze and summarize all clinical studies regarding the impacts of Ramadan fasting for patients with NAFLD.MethodsWe performed a comprehensive search of the Embase, Cochrane, and PubMed databases from inception to September 1, 2023. All clinical studies concerning the impacts of Ramadan fasting on patients with NAFLD were included.ResultsIn total, six studies with 397 NAFLD patients comprising five prospective studies and one retrospective study were included in the systematic review. All six studies were assessed as high-quality. Ramadan fasting may offer potential benefits for patients with NAFLD, including improvements in body weight, body composition, cardiometabolic risk factors, glucose profiles, liver parameters, and inflammation markers.ConclusionRamadan fasting might be an effective dietary intervention for NAFLD. However, the number of studies examining the impacts of Ramadan fasting for patients with NAFLD is relatively limited. Therefore, more high-quality research is needed to further our understanding of the benefits of Ramadan fasting for NAFLD.Systematic review registrationhttps://inplasy.com, identifier 202390102.
Comparison of the transcriptome and metabolome of wheat (Triticum aestivum L.) proteins content during grain formation provides insight
Authors: Shi Jia , Wang Lihong , Wang Zhong , Li Jianfeng , Zhang Hongzhi , Gao Xin , Wang Chunsheng , Xia Jianqiang , Zhao Zhun , Wang Zhenlong , Yang Zhenyu , Xu Zihan , Zhang Yueqiang , Fan Zheru 
Published: January 2024

IntroductionWheat is a food crop with a large global cultivation area, and the content and quality of wheat glutenin accumulation are important indicators of the quality of wheat flour.MethodsTo elucidate the gene expression regulation and metabolic characteristics related to the gluten content during wheat grain formation, transcriptomic and metabolomic analyses were performed for the high gluten content of the Xinchun 26 cultivar and the low proteins content of the Xinchun 34 cultivar at three periods (7 d, 14 d and 21 d) after flowering.ResultsTranscriptomic analysis revealed that 5573 unique differentially expressed genes (DEGs) were divided into two categories according to their expression patterns during the three periods. The metabolites detected were mainly divided into 12 classes. Lipid and lipid-like molecule levels and phenylpropanoid and polyketide levels were the highest, and the difference analysis revealed a total of 10 differentially regulated metabolites (DRMs) over the three periods. Joint analysis revealed that the DEGs and DRMs were significantly enriched in starch and sucrose metabolism; the citrate cycle; carbon fixation in photosynthetic organisms; and alanine, aspartate and glutamate metabolism pathways. The genes and contents of the sucrose and gluten synthesis pathways were analysed, and the correlation between gluten content and its related genes was calculated. Based on weighted correlation network analysis (WGCNA), by constructing a coexpression network, a total of 5 specific modules and 8 candidate genes that were strongly correlated with the three developmental stages of wheat grain were identified.DiscussionThis study provides new insights into the role of glutenin content in wheat grain formation and reveals potential regulatory pathways and candidate genes involved in this developmental process.
Recurrent cannabis-induced catatonia: a case report and comprehensive systematic literature review
Authors: Moshfeghinia Reza , Hosseinzadeh Mehrnaz , Mostafavi Sara , Jabbarinejad Roxana , Malekpour Mahdi , Chohedri Elnaz , Ahmadi Jamshid 
Published: January 2024

BackgroundCatatonia presents itself as a complex neuropsychiatric syndrome, giving rise to various motor, speech, and behavioral challenges. It is noteworthy that approximately 10% of psychiatric hospital admissions can be attributed to this condition. It is imperative to note that cannabis-induced catatonia, while infrequent, has been linked to the use of marijuana. This connection has the potential to disrupt neurotransmitter systems, necessitating further research for a comprehensive understanding and effective treatment, particularly given the evolving trends in cannabis use. In this context, we shall delve into a unique case of recurrent cannabis-induced catatonia.Case presentationA 23-year-old gentleman, who has previously struggled with substance use disorder, experienced the emergence of mutism, social isolation, and a fixed gaze subsequent to his use of cannabis. Remarkably, despite the absence of hallucinations, he exhibited recurrent episodes of catatonia. These episodes were effectively addressed through a combination of electroconvulsive therapy (ECT) and lorazepam administration. Notably, when the lorazepam dosage was gradually reduced to below 2 mg per day, the catatonic symptoms resurfaced; however, they promptly abated upon reinstating the medication. The diagnosis of cannabis-induced catatonia was established, and its management primarily involved a therapeutic approach encompassing ECT and lorazepam. It is pertinent to underscore that this catatonic condition can be directly linked to the individual’s cannabis usage.ConclusionThe connection between cannabis and catatonia is intricate and not entirely comprehended. Although cannabis possesses therapeutic advantages, it can paradoxically trigger catatonia in certain individuals. Multiple factors, such as genetics, cannabinoids, and neurotransmitter systems, contribute to this intricacy, underscoring the necessity for additional research.
The positivity rates and drug resistance patterns of Mycobacterium tuberculosis using nucleotide MALDI-TOF MS assay among suspected tuberculosis patients in Shandong, China: a multi-center prospective study
Authors: Gao Xusheng , Li Tongxia , Han Wenge , Xiong Yu , Xu Shiyang , Ma Hongbao , Wang Qing , Zhang Qiuxia , Yang Guofeng , Xie Dan , Jiang Peipei , Wu Hailiang , Lin Mei , Liu Min , Ni Mingde , Wang Decui , Li Ying , Jiao Lunxian , Ding Caihong , Zhang Zhongfa 
Published: January 2024

ObjectiveTo investigate the positivity rates and drug resistance characteristics of Mycobacterium tuberculosis (MTB) among suspected tuberculosis (TB) patients in Shandong Province, the second-largest population province in China.MethodsA prospective, multi-center study was conducted from April 2022 to June 2023. Pathogen and drug resistance were identified using nucleotide matrix-assisted laser desorption ionization time-of-flight mass spectrometry (nucleotide MALDI-TOF MS).ResultsOf 940 suspected TB patients included in this study, 552 cases were found to be infected with MTB giving an overall positivity rate of 58.72%. Total of 346 cases were resistant to arbitrary anti-TB drug (62.68%), with Zibo (76.47%), Liaocheng and Weihai (both 69.23%) ranking top three and TB treatment history might be a related factor. Monoresistance was the most common pattern (33.53%), with isoniazid the highest at 12.43%, followed by rifampicin at 9.54%. Further analysis of gene mutations conferring resistance revealed diverse types with high heteroresistance rate found in multiple anti-TB drugs.ConclusionA relatively high rate of MTB positivity and drug resistance was found in Shandong Province during and after the COVID-19 pandemic, indicating the need for strengthening rapid identification of species and drug resistance among suspected TB patients to guide better medication and minimize the occurrence of drug resistance.