bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility and greenness appraisal of nuclear magnetic resonance for sustainable simultaneous determination of three 1,4-benzodiazepines and their main impurity 2-amino-5-chlorobenzophenone
Authors: Qandeel Nermeen A. , El-Masry Amal A. , El-Shaheny Rania , Eid Manal , Moustafa Mohamed A. 
Published: November 2023

AbstractA robust, stability-indicating, and eco-friendly proton nuclear magnetic resonance (1H-qNMR) method was developed for the concurrent determination of three 1,4-benzodiazepines (BDZs), namely diazepam (DZP), alprazolam (ALP), and chlordiazepoxide (CDP) and their common impurity, synthesis precursor, and degradation product; 2-amino-5-chlorobenzophenone (ACB). In the present method, a novel approach was developed for composing a green and cost-efficient solvent system as an alternative to the common NMR organic solvents utilizing 0.3 M sodium dodecyl sulfate prepared in deuterated water. The conducted method is characterized by simplicity with no need for sample pretreatment or labeling. Phloroglucinol was used as an internal standard. The chosen signals for the determinations of ALP, CDP, DZP and ACB were at 2.35 ppm (singlet), 2.84 ppm (singlet), 3.11 ppm (singlet), and 6.90 ppm (doublet of doublet), respectively. The proposed method possessed linearity over the concentration range of 0.25–15.0 mg ml−1 for DZP, ALP, CDP and of 0.5–25.0 mg ml−1 for ACB with LOD values of 0.06, 0.03, 0.07 and 0.16 mg ml−1 respectively, and LOQ values of 0.18, 0.09, 0.21 and 0.49 mg ml−1, respectively. Accuracy of the method was evidenced by excellent recovery% (99.57–99.90%) and small standard deviation (≥ 1.10) for the three analyzed drugs. Intra- and inter-day precision were determined with coefficient of variation ranging from 0.12 to 1.14 and from 0.72 to 1.67, respectively. For the studied compounds, appraisal of the method greenness was achieved via four approaches: Analytical Eco-Scale, Green Analytical Procedure Index (GAPI), Analytical greenness metric (AGREE), and RGB Additive Color Model. The results proved that the proposed method has the privilege of being a green analytical method.
Historical shifting in grain mineral density of landmark rice and wheat cultivars released over the past 50 years in India
Authors: Debnath Sovan , Dey Ahana , Khanam Rubina , Saha Susmit , Sarkar Dibyendu , Saha Jayanta K. , Coumar Mounissamy V. , Patra Bhaskar C. , Biswas Tufleuddin , Ray Mrinmoy , Radhika Madhari S. , Mandal Biswapati 
Published: November 2023

AbstractThe ‘Green Revolution (GR)’ has been successful in meeting food sufficiency in India, but compromising its nutritional security. In a first, we report altered grain nutrients profile of modern-bred rice and wheat cultivars diminishing their mineral dietary significance to the Indian population. To substantiate, we evaluated grain nutrients profile of historical landmark high-yielding cultivars of rice and wheat released in succeeding decades since the GR and its impacts on mineral diet quality and human health, with a prediction for decades ahead. Analysis of grain nutrients profile shows a downward trend in concentrations of essential and beneficial elements, but an upward in toxic elements in past 50 y in both rice and wheat. For example, zinc (Zn) and iron (Fe) concentration in grains of rice decreased by ~ 33.0 (P < 0.001) and 27.0% (P < 0.0001); while for wheat it decreased by ~ 30.0 (P < 0.0001) and 19.0% (P < 0.0001) in past more than 50 y, respectively. A proposed mineral-diet quality index (M-DQI) significantly (P < 0.0001) decreased ~ 57.0 and 36.0% in the reported time span (1960–2010) in rice and wheat, respectively. The impoverished M-DQI could impose hostile effects on non-communicable diseases (NCDs) like iron-deficiency anemia, respiratory, cardiovascular, and musculoskeletal among the Indian population by 2040. Our research calls for an urgency of grain nutrients profiling before releasing a cultivar of staples like rice and wheat in the future.
Application of 20% silver nanoclusters in polymethacrylic acid on simulated dentin caries; its penetration depth and effect on surface hardness
Authors: Cabalén Maria Belén , Molina Gustavo Fabian , Piscitelli Vincent , Rossa Maximiliano , Aranguren Juan Pablo , Palma Santiago Daniel , Pino Gustavo Ariel , Picca Mariana , Burrow Michael Francis 
Published: November 2023

AbstractThe aims of this study were: To evaluate the surface hardness of simulated dentin caries lesions treated with either silver nanoclusters (AgNCls) synthesized in polymethacrylic acid (PMAA) or 38% silver diammine fluoride (SDF), as well as observe the penetration of the treatment solutions into the simulated caries lesions. Dentin blocks 4 mm thick obtained from caries-free third molars were sectioned and then simulated caries lesions on the occlusal dentin surfaces were created. Each specimen (n = 8) was divided into four sections: (A) treated with 20% AgNCls/PMAA; (B) treated with SDF 38% (FAgamin, Tedequim, Cordoba, Argentina); (C) sound tooth protected by nail-varnish during artificial caries generation (positive control); and (D) artificial caries lesion without surface treatment (negative control). AgNCls/PMAA or SDF were applied on the simulated lesions with a microbrush for 10 s, then excess removed. The surface hardness was measured by means of Vickers indentation test. To trace the depth of penetration, up to 400 μm, of silver ions, elemental composition of the samples was observed using EDX, coupled with SEM, and measured every 50 μm from the surface towards the pulp chamber. Laser Induced Breakdown Spectroscopy (LIBS) was also employed to trace silver ion penetration; the atomic silver line 328.06 nm was used with a 60 μm laser spot size to a depth of 240 μm. Student’s-t test identified significant differences between treatment groups for each depth and the Bonferroni test was used for statistical analysis of all groups (p < 0.05). Mean surface hardness values obtained were 111.2 MPa, 72.3 MPa, 103.3 MPa and 50.5 MPa for groups A, B, C and D respectively. There was a significant difference between groups A and C compared with groups B and D, the group treated with AgNCls/PMAA achieved the highest surface hardness, similar or higher than the sound dentin control. A constant presence of silver was observed throughout the depth of the sample for group A, while group B showed a peak concentration of silver at the surface with a significant drop beyond 50 μm. The 20% AgNCls/PMAA solution applied to simulated dentin caries lesions achieved the recovery of surface hardness equivalent to sound dentin with the penetration of silver ions throughout the depth of the lesion.
Integrated control of braking-yaw-roll stability under steering-braking conditions
Authors: Chen Jia , Liu Yihang , Liu Renping , Xiao Feng , Huang Jian 
Published: November 2023

AbstractSharp steering-braking at a high speed exposes sport utility vehicles with high gravity centers and narrow wheel tracks to the risks of tire locking, sideslip and rollover. To avoid these risks and ensure braking safety, yaw stability and roll stability upon steering-braking, a braking-yaw-roll stability integrated control strategy was proposed, which consists of a supervisor, an upper and a lower controller for the front and rear axle independent drive electric vehicle. In the supervisor, a nonlinear vehicle predictive model was constructed and four control modes were proposed according to the vehicle status and rollover indexes. The weight coefficients between braking force, yaw stability and roll stability are determined dynamically by the control mode and output to the upper controller. The upper controller used a nonlinear model predictive control to determine the longitudinal braking force distribution of the four wheels. And in the lower controller, the regenerative braking torque and friction braking torque of each wheel were distributed. Finally, simulation verifications were carried out on the high and low adhesion roads. The results show that the control strategy proposed in this study can effectively prevent the vehicle from rollover while ensuring braking safety and yaw stability.
Cryovacuum setup for optical studies of astrophysical ice
Authors: Golikov Oleg , Yerezhep Darkhan , Akylbayeva Aigerim , Sokolov Dmitriy Yurievich , Korshikov Eugeniy , Nurmukan Assel , Aldiyarov Abdurakhman 
Published: November 2023

AbstractThis paper presents a cryovacuum setup for the study of substances under near-space conditions. The setup makes it possible to study the infrared spectra, refractive index, and density of substances that are condensed from the vapor phase onto a cooled substrate in the temperature range from 11 to 300 K. At the same time, it is possible to obtain the ultimate pressure of 1 × 10–10 Torr in the vacuum chamber. The presented setup is based on FTIR spectroscopy (the spectral measurement range is 400–7800 cm–1) and laser interference, through which the important physical and optical parameters are determined. A number of experiments allow us to point out that the data obtained using this setup correlate well with the experiments of other authors. Due to the non-directional deposition of substances from the vapor phase, the ice formed resembles the one formed under cosmic conditions as closely as possible, which makes the presented setup particularly valuable. The presented cryovacuum setup can be used for the interpretation of data obtained during astrophysical observations, providing a means to determine the properties of cosmic objects.
Advancing breast cancer diagnosis with a near-infrared fluorescence imaging smart sensor for estrogen/progesterone receptor detection
Authors: Zhang Gong , Dong Min , Yao Xiulei , Xia Yuke , Yu Han , zhou Yu , Lian Chao , Zhang Yunlei , Cui Yiyao 
Published: November 2023

AbstractMolecular-genetic imaging has greatly advanced clinical diagnosis and prognosis monitoring. However, the specific visualization of intracellular proteins such as estrogen receptor (ER) and progesterone receptor (PR) remains an elusive goal. Here, we highlight a novel method for selectively detecting ER/PR positive tumors using genetically engineered responsive elements. Our study demonstrates that the double responsive elements of ER/PR exhibit the most sensitivity to the steroid receptors in breast cancers. By utilizing a cationic polymer vector, we constructed a responsive element-fluorescence protein system that can selectively image ER/PR positive breast cancers in murine models under a near-infrared laser. This non-invasive imaging achieved high-resolution detection without death or serious anaphylactic activity in the animals. Our findings suggest that the reporter system consisting of steroid receptor response elements and near-infrared proteins provides a practical system for identifying biomarkers and advancing cancer diagnosis and therapy.
Effect of temperature on fast transmission of COVID-19 in low per capita GDP Asian countries
Authors: Haq Faraz ul , Abduljaleel Yasir , Ahmad Ijaz 
Published: November 2023

AbstractAn abrupt outbreak of COVID-19 caused enormous global concerns. Although all countries around the world are severely affected, developing Asian countries faced more difficulties due to their low per capita GDP. The temperature was considered a leading variable in spreading viral diseases, including COVID-19. The present study aimed to assess the relationship between temperature and the spread of COVID-19, with a focus on developing Asian countries. In a few Asian countries, COVID-19 spread rapidly in the summer, while in some countries, there is an increase in winter. A linear correlation was developed between COVID-19 cases/deaths and temperature for the selected countries, which were very weak. A coefficient of determination of 0.334 and 0.365 was observed between cases and average monthly max/min temperatures. A correlation of R2 = 0.307 and 0.382 was found between deaths and average max/min monthly temperatures, respectively. There is no scientific reason to assume that COVID-19 is more dominant at low than high temperatures. Therefore, it is believed that the results may be helpful for the health department and decision-makers to understand the fast spread of COVID-19.
Entwicklung einer nationalen Strategie für gen- und
zellbasierte Therapien
Authors: Klump Hannes , Schäfer Richard 
Published: November 2023

ZusammenfassungDie Erfolge der gen- und zellbasierten Therapien (GCT), insbesondere mittels
CAR-T-Zellen, haben in den letzten Jahren deren Kommerzialisierung
vorangetrieben. Deutschland fällt jedoch im internationalen Vergleich
bei der klinischen Umsetzung der Forschungsergebnisse und wirtschaftlichen
Verwertung der GCT immer weiter zurück. Um konkrete Maßnahmen
dagegen auszuarbeiten, wurde die „Nationale Strategie für gen-
und zellbasierte Therapien“ ins Leben gerufen, die vom Berlin Institute
of Health (BIH) koordiniert und umgesetzt werden wird. Dieser Artikel fasst den
Status quo der Initiative zusammen, mit einem besonderen Blick auf die Rolle der
Transfusionsmedizin.
ChatGPT and Rhinoplasty Recovery: An Exploration of AI's Role in Postoperative Guidance
Authors: Capelleras Marta , Soto-Galindo Germán A. , Cruellas Marc , Apaydin Fazil 
Published: November 2023

AbstractThe potential applications of artificial intelligence (AI) in health care have garnered significant interest in recent years. This study presents the first published exploration of ChatGPT, an AI language model, as a tool for providing postoperative guidance during rhinoplasty recovery. The primary objective was to shed light on the role of ChatGPT in augmenting patient care during the critical postoperative phase. Using the Rhinobase database, standardized questions were formulated to evaluate AI-generated responses addressing pain management, swelling, bruising, and potential asymmetries. Results demonstrated that ChatGPT has the potential to enhance patient education and alleviate emotional distress by providing general information and reassurance during the recovery process. However, the study emphasized that AI should not replace personalized advice from qualified health care professionals. This pioneering investigation offers valuable insights into the integration of AI and human expertise, paving the way for optimized postrhinoplasty recovery care.
Inflammatory Modifications in Paranasal Sinuses and Ostiomeatal Complex Anatomical Variations in Jet Aircraft Pilots: A Computed Tomography Study
Authors: da Silva Yeda , Munhoz Luciana , Parga Filho José Rodrigues , Damasceno Andreza Gomes , Rosa Cesar Felipe França da , Zukovski Eduardo Bilaqui , Teng Erik Zhu , Arita Emiko Saito , Castro Cláudio Campi de 
Published: November 2023

Abstract
Introduction Jet aircraft pilots are exposed to huge pressure variation during flight, which affect physiological functions as systems, such as the respiratory system.
Objectives The objective of the present investigation was to evaluate inflammatory changes of paranasal sinuses of jet aircraft pilots before and after a jet aircraft training program, using multislice computed tomography (CT), in comparison with a group of nonairborne individuals with the same age, sex, and physical health conditions. A second objective of the present study was to assess the association between the ostiomeatal complex obstruction and its anatomical variations.
Methods The study group consisted of 15 jet aircraft pilots participating in the training program. The control group consisted of 41 nonairborne young adults. The 15 fighter pilots were evaluated before initiating the training program and after their final approval for the presence of inflammatory paranasal sinus disease. The ostiomeatal complex anatomical variations and obstructions were analyzed in pilots after the training program.
Results Jet aircraft pilots presented higher incidence of mucosal thickening in maxillary sinus and anterior ethmoid cells than controls. Prominent ethmoidal bulla showed significant association with obstruction of the osteomeatal complex.
Conclusions Jet aircraft pilots present increased inflammatory disease when compared with nonairborne individuals. The presence of a prominent ethmoidal bulla is associated with ostiomeatal complex obstruction.
To stay, remain or leave: how verbal concepts as response options in political referendums such as the Brexit polls might bias voting outcomes
Authors: Ströbel Liane , Koch Iring , Salge Torsten-Oliver , Antons David 
Published: November 2023

AbstractReferendums allow people to participate in political decision-making. However, they also come with the challenge of presenting complex issues to the electorate in a concise and comprehensible way. In order to simplify the decision-making process, referendum questions are often tailored toyes/noresponse options. In comparison, the UK European Union membership referendum of 2016, in contrast to the 1975 referendum on the same issue, discarded this option, and a verbal and conceptually more complex alternative response option was brought into play (remainvs.leave). This potentially relevant change in the voting tradition justifies a linguistic consideration of the suitability of the choice of verbs. Verbal response options such asstay, remainandleavemight activate different framing effects due to their underlying etymology. Our goal was therefore to examine whether the choice of verbs can have a biasing effect, which might be the case due to their frame-inherent structure. This investigation attempts, through both a linguistic analysis and an experimental analysis using a version of the Implicit Association Test (IAT), to bridge the research gap between the awareness that there are linguistic factors that can influence decision-making processes and the lack of inclusion of framing effects. Overall, the data of two IAT studies (n = 185andn = 355) suggest that the exact wording of dichotomic response options has the potential to influence response choice based on evaluative associations of the verbs. Specifically, when compared toleave, we found relatively more positive evaluation forstaythan forremain. Furthermore - independent of the Brexit referendum - our study raises the question whether verbs are at all suitable to replaceyes/noresponse options due to inherent framing effects. This linguistic aspect requires more attention in the design of response options in future referendums.
Reverse time migration surface offset gathers by attribute migration and constrained least-squares inversion
Authors: Zheng Yingdong , Liu Guofeng 
Published: November 2023

Abstract
Surface offset gathers (SOGs) are crucial for velocity updating in seismic data migration and muting the stretched waveform in shallow parts of migrated seismic data. Kirchhoff-based migration methods can output SOGs because they take every seismic trace as the input. As a result, the imaging results can be rearranged according to the offset value of the input data to obtain SOGs. However, regarding more accurate wave equation methods (such as reverse time migration, RTM), the SOGs cannot be obtained directly with a single migration calculation. Attribute migration is an easy-to-implement method to output SOGs of wave equation migration methods. It calculates the offset value of each imaging point by dividing the migration result modulated by the offset attribute with the conventional migration result. However, the division error may cause the calculation result outside the given offset value. This paper proposes a constrained least-squares inversion method for stable calculation of the RTM offset range. The method ensures that the calculated results are within the given offset range. We tested the method against the direct division and least-squares methods without constraints using the Marmousi model and a real 3D dataset. We show that the SOGs obtained by the constrained least-squares inversion attribute migration method had the same characteristics as those derived using the division-based attribute migration method, but they also had higher vertical resolution, better energy distribution, and improved lateral continuity. In a further study, we expect to develop a stable and direct method to efficiently calculate SOGs for RTM and an iterative closed loop for RTM velocity updating.
Pulsar scintillation through thick and thin: bow shocks, bubbles, and the broader interstellar medium
Authors: Ocker Stella Koch , Cordes James M , Chatterjee Shami , Stinebring Daniel R , Dolch Timothy , Giannakopoulos Christos , Pelgrims Vincent , McKee James W , Reardon Daniel J 
Published: November 2023

ABSTRACT
Observations of pulsar scintillation are among the few astrophysical probes of very small-scale (≲ au) phenomena in the interstellar medium (ISM). In particular, characterization of scintillation arcs, including their curvature and intensity distributions, can be related to interstellar turbulence and potentially overpressurized plasma in local ISM inhomogeneities, such as supernova remnants, H ii regions, and bow shocks. Here we present a survey of eight pulsars conducted at the Five-hundred-metre Aperture Spherical Telescope (FAST), revealing a diverse range of scintillation arc characteristics at high sensitivity. These observations reveal more arcs than measured previously for our sample. At least nine arcs are observed toward B1929+10 at screen distances spanning $\sim 90~{{\ \rm per\ cent}}$ of the pulsar’s 361 pc path length to the observer. Four arcs are observed toward B0355+54, with one arc yielding a screen distance as close as ∼105 au (&lt;1 pc) from either the pulsar or the observer. Several pulsars show highly truncated, low-curvature arcs that may be attributable to scattering near the pulsar. The scattering screen constraints are synthesized with continuum maps of the local ISM and other well-characterized pulsar scintillation arcs, yielding a three-dimensional view of the scattering media in context.
Genetic Modification of a Hox Locus Drives Mimetic Color Pattern Variation in a Highly Polymorphic Bumble Bee
Authors: Yang Wanhu , Cui Jixiang , Chen Yuxin , Wang Chao , Yin Yuanzhi , Zhang Wei , Liu Shanlin , Sun Cheng , Li Hu , Duan Yuange , Song Fan , Cai Wanzhi , Hines Heather M , Tian Li 
Published: November 2023

Abstract
Müllerian mimicry provides natural replicates ideal for exploring mechanisms underlying adaptive phenotypic divergence and convergence, yet the genetic mechanisms underlying mimetic variation remain largely unknown. The current study investigates the genetic basis of mimetic color pattern variation in a highly polymorphic bumble bee, Bombus breviceps (Hymenoptera, Apidae). In South Asia, this species and multiple comimetic species converge onto local Müllerian mimicry patterns by shifting the abdominal setal color from orange to black. Genetic crossing between the orange and black phenotypes suggested the color dimorphism being controlled by a single Mendelian locus, with the orange allele being dominant over black. Genome-wide association suggests that a locus at the intergenic region between 2 abdominal fate-determining Hox genes, abd-A and Abd-B, is associated with the color change. This locus is therefore in the same intergenic region but not the same exact locus as found to drive red black midabdominal variation in a distantly related bumble bee species, Bombus melanopygus. Gene expression analysis and RNA interferences suggest that differential expression of an intergenic long noncoding RNA between abd-A and Abd-B at the onset setal color differentiation may drive the orange black color variation by causing a homeotic shift late in development. Analysis of this same color locus in comimetic species reveals no sequence association with the same color shift, suggesting that mimetic convergence is achieved through distinct genetic routes. Our study establishes Hox regions as genomic hotspots for color pattern evolution in bumble bees and demonstrates how pleiotropic developmental loci can drive adaptive radiations in nature.