bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basic leucine zipper transcription factors C/EBP and MafL in the hydrozoan jellyfish Podocoryne carnea
Authors: Seipel Katja , Yanze Nathalie , Müller Peter , Streitwolf Ruth , Schmid Volker 
Published: May 2004

AbstractMembers of the CCAAT/enhancer binding protein (C/EBP) and the Maf protein subfamilies have been characterized in a variety of bilaterian organisms. This is the first report of C/EBP and MafL genes in a basal organism, the hydrozoan jellyfish Podocoryne carnea. Transcripts of both genes are present in all life cycle stages: egg, embryo, larva, polyp, and medusa. During early development, both factors appear to regulate metamorphosis of the larva to the primary polyp. Both genes are also expressed in the striated muscle of the developing and adult medusa. During in vitro transdifferentiation of striated muscle cells to smooth muscle and nerve cells, C/EBP is continuously expressed, whereas MafL expression is turned off during transdifferentiation and reactivated when nerve cells differentiate. Thus, both factors may be involved in muscle and nerve cell differentiation. In the mature medusa both genes are also implicated in gametogenesis. Developmental and evolutionary aspects of the gene structures and expression patterns are discussed. Developmental Dynamics 230:392–402, 2004. © 2004 Wiley‐Liss, Inc.
Functional link between retinoblastoma family of proteins and the Wnt signaling pathway in mouse epidermis
Authors: Ruiz Sergio , Segrelles Carmen , Santos Mirentxu , Lara M. Fernanda , Paramio Jesús M. 
Published: May 2004

AbstractThe retinoblastoma family of proteins (pRb, p107, and p130) modulates cell cycle progression and differentiation of several tissues. We have demonstrated recently that p107 and p130 regulate keratinocyte terminal differentiation and hair follicle morphogenesis and development in vivo. This last aspect appears to be mediated by defective signaling from the mesenchyme and is associated with altered bone morphogenetic protein‐4 (BMP4) ‐dependent signaling. However, many alterations were also found in the epithelial compartment. Given the importance of βcatenin in hair biology and in BMP signaling, we studied its expression in p107/p130‐deficient skin. Although normal expression of βcatenin was found in p107/p130‐deficient hair follicles, we found increased nuclear accumulation of βcatenin in the basal keratinocytes of the p107/p130‐deficient mice skin. Biochemical analysis revealed that such an increase in βcatenin was due to the disruption of Axin/GSK3β/βcatenin complexes promoted by the increased expression of Frat, the mouse homologue of GSK3βbinding protein (GBP), in epidermis, precluding the degradation of βcatenin. Collectively, these data represent the first evidence that retinoblastoma family and Wnt signaling pathways might be interconnected by functional links in skin. Developmental Dynamics 230:410–418, 2004. © 2004 Wiley‐Liss, Inc.
Genetic interactions underlying otic placode induction and formation
Authors: Solomon Keely S. , Kwak Su‐Jin , Fritz Andreas 
Published: May 2004

AbstractThe formation of the otic placode is a complex process requiring multiple inductive signals. In zebrafish, fgf3 and fgf8, dlx3b and dlx4b, and foxi1 have been identified as the earliest‐acting genes in this process. fgf3 and fgf8 are required as inductive signals, whereas dlx3b, dlx4b, and foxi1 appear to act directly within otic primordia. We have investigated potential interactions among these genes. Depletion of either dlx3b and dlx4b or foxi1 leads to a delay of pax2a expression in the otic primordia and reduction of the otic vesicle. Depletion of both foxi1 and dlx3b results in a complete ablation of otic placode formation. A strong synergistic interaction is also observed among foxi1, fgf3, and fgf8, and a weaker interaction among dlx3b, fgf3, and fgf8. Misexpression of foxi1 can induce expression of pax8, an early marker for the otic primordia, in embryos treated with an inhibitor of fibroblast growth factor (FGF) signaling. Conversely, morpholino knockdown of foxi1 blocks ectopic pax8 expression and otic vesicle formation induced by misexpression of fgf3 and/or fgf8. The observed genetic interactions suggest a model in which foxi1 and dlx3b/dlx4b act in independent pathways together with distinct phases of FGF signaling to promote otic placode induction and development. Developmental Dynamics 230:419–433, 2004. © 2004 Wiley‐Liss, Inc.
Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade
Authors: Kamimura Mika , Matsumoto Ken , Koshiba‐Takeuchi Kazuko , Ogura Toshihiko 
Published: May 2004

AbstractIn vertebrates and invertebrates, BMP/Dpp (Bone Morphogenetic Protein/Decapentaplegic) signaling regulates the orchestrated processes of embryogenesis. Recent studies have revealed that BMP/Dpp signaling is controlled extracellularly as well as intracellularly. One extracellular regulatory molecule is the Chordin/Short gastrulation protein (Chordin/Sog), a secreted protein that acts as an antagonist to BMP/Dpp. Chordin/Sog contains four cysteine‐rich (CR) domains that bind to and inactivate BMP/Dpp. In contrast, a positive regulator has been identified in Drosophila. Named crossveinless 2 (cv‐2), this molecule contains five CR domains at the N‐terminal half and a von Willebrand factor D domain at the C‐terminal part. Genetic data suggest that Cv‐2 potentiates Dpp signaling. We isolated chick and mouse CV‐2 genes and found that CV‐2 is secreted and enhances BMP signaling. Expression patterns were closely related to those of BMPs, supporting the likelihood of a tight link. Our data show for the first time that CV‐2 is a conserved, positive regulator of BMP signaling and that CR domain proteins act as both positive and negative modulators of BMP signaling. Developmental Dynamics 230:434–445, 2004. © 2004 Wiley‐Liss, Inc.
Msx1 disruption leads to diencephalon defects and hydrocephalus
Authors: Ramos Casto , Fernández‐Llebrez Pedro , Bach Antoine , Robert Benoît , Soriano Eduardo 
Published: May 2004

AbstractWe have analyzed the expression of the Msx1 gene in the developing mouse brain and examined the brain phenotype in homozygotes. Msx1 is expressed in every cerebral vesicle throughout development, particularly in neuroepithelia, such as those of the fimbria and the medulla. Timing analysis suggests that Msx1nLacZ cells delaminate and migrate radially from these epithelia, mainly at embryonic days 14–16, while immunohistochemistry studies reveal that some of the β‐galactosidase migrating cells are oligodendrocytes or astrocytes. Our results suggest that the Msx1 neuroepithelia of fimbria and medulla may be a source of glial precursors. The Msx1 mutants display severe hydrocephalus at birth, while the subcommissural organ, the habenula, and the posterior commissure fail to develop correctly. No label was detected in the mutant subcommissural organ using a specific antibody against Reissner's fiber. Besides, the fasciculus retroflexus deviates close to the subcommissural organ, while the paraventricular thalamic nucleus shows histological disorganization. Our results implicate the Msx1 gene in the differentiation of the subcommissural organ cells and posterior commissure and that Msx1 protein may play a role in the pathfinding and bundling of the fasciculus retroflexus and in the structural arrangement of the paraventricular thalamic nucleus. Developmental Dynamics 230:446–460, 2004. © 2004 Wiley‐Liss, Inc.
Independent induction and formation of the dorsal and ventral fins in Xenopus laevis
Authors: Tucker A.S. , Slack J.M.W. 
Published: May 2004

AbstractIt has been known since the 1930s that the dorsal fin is induced by the underlying neural crest. The inducer of the ventral fin, however, has remained elusive. We have investigated the source of the inducer of the ventral fin in Xenopus and show that it is the ventral mesoderm and not the neural crest. This induction takes place during mid‐neurula stages and is completed by late neurulation. In terms of cell composition, the dorsal fin mesenchyme core arises from neural crest cells, while the mesenchyme of the ventral fin has a dual origin. The ventral fin contains neural crest cells that migrate in from the dorsal side of the embryo, but a contribution is also made by cells from the ventral mesoderm. Developmental Dynamics 230:461–467, 2004. © 2004 Wiley‐Liss, Inc.
Influence of endostatin on embryonic vasculo‐ and angiogenesis
Authors: Schmidt Annette , Wenzel Daniela , Ferring Isabell , Kazemi Shohreh , Sasaki Takako , Hescheler Jürgen , Timpl Rupert , Addicks Klaus , Fleischmann Bernd K. , Bloch Wilhelm 
Published: May 2004

AbstractThe proteolytic fragment of collagen XVIII, endostatin, acts as an inhibitor of angiogenesis. To date, only limited knowledge exists on the effects of endostatin on endothelial cells during embryonic development. Therefore, we analysed the role of endostatin on embryonic vasculo‐ and angiogenesis. Endostatin is accumulated in embryonic tissue of mouse embryos. Similarly, in vessels of embryoid bodies (EBs), endostatin and its binding sites are distributed in vessels and sprouting areas. In EBs, endostatin increases endothelial cells (control, 279.3 ± 76.5; 50 ng/ml, 566.3 ± 90.1; 200 ng/ml, 594.5 ± 166.3 tube‐like structures per EB) and endothelial tubes by proliferation (control, 21.4 ± 7.5; 50 ng/ml, 160.2 ± 9.9; 200 ng/ml, 184.2 ± 16.5 Ki67‐positive nuclei per 50 tube‐like structures); it also enhances migration (control, 380.5 ± 159.8 cells; 50 ng/ml, 718.3 ± 251 cells; 200 ng/ml, 706 ± 89.4 cells) and apoptosis (control, 16.8 ± 6.7; 50 ng/ml, 94.4 ± 23.6; 200 ng/ml, 106 ± 42 PARP‐positive nuclei per 50 tube‐like structures). Furthermore, endostatin modulates the morphology of the endothelial tubes by inducing contraction. Endostatin modulates the embryonic vascular development by enhancing proliferation, migration, and apoptosis as well as by regulating morphogenesis. Developmental Dynamics 230:468–480, 2004. © 2004 Wiley‐Liss, Inc.
Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish
Authors: Boehmler Wendy , Obrecht‐Pflumio Sophie , Canfield Victor , Thisse Christine , Thisse Bernard , Levenson Robert 
Published: May 2004

AbstractWe mined the zebrafish genomic sequence database and identified contigs containing segments of several dopamine receptor genes. By using a polymerase chain reaction amplification strategy, we generated full‐length cDNAs encoding a single dopamine D3 receptor and three distinct D2 receptor subtypes. Zebrafish dopamine receptor genes were mapped by using the T51 radiation hybrid panel. The D3 receptor gene (drd3) mapped to linkage group (LG) 24. The three D2 receptor genes were localized to LG 15 (drd2a), LG 16, (drd2b), and LG 5 (drd2c). With the exception of the drd2b gene, each of these map positions was syntenic with regions of human chromosomes containing orthologs of the zebrafish dopamine receptor genes. Whole‐mount in situ hybridization was used to investigate expression of the D2 and D3 receptor genes. Expression of the drd3 gene was first detected at mid‐somitogenesis and was particularly prominent in somites. Thereafter, the drd3 gene was expressed diffusely throughout the brain and spinal cord. The three D2 receptor genes were expressed throughout the central nervous system (CNS) in distinct but overlapping patterns. In early embryos, the drd2a gene was expressed exclusively in the epiphysis, whereas the drd2c gene was localized to the notochord. After 24 hpf, the drd2a, drd2b, and drd2c genes were differentially expressed throughout the CNS. The identification of dopamine receptor genes in zebrafish should allow us to use the power of zebrafish genetics to analyze the functional properties of this important class of neurotransmitter receptors. Developmental Dynamics 230:481–493, 2004. © 2004 Wiley‐Liss, Inc.
Interleukin‐5 participates in the pathogenesis of ileitis in SAMP1/Yit mice
Authors: Takedatsu Hidetoshi , Mitsuyama Keiichi , Matsumoto Satoshi , Handa Kazuyo , Suzuki Asuka , Takedatsu Hiroko , Funabashi Hideyuki , Okabe Yoshio , Hara Taeko , Toyonaga Atsushi , Sata Michio 
Published: May 2004

AbstractSAMP1/Yit mice spontaneously develop ileitis resembling Crohn's disease (CD) without chemical or genetic manipulations. Since the focus of studies were Th1 cytokines, only Th1‐type T cells were thought to be responsible for intestinal inflammation in these mice. To further characterize the pathogenesis of this ileitis, we investigated the implication of Th2 cytokines in ileitis of SAMP1/Yit mice. The expression of chemokine receptors (CCR) associated with both Th1 and Th2 lymphocytes, such as CCR2, CCR3, CCR4, CCR5, and CCR8, was increased. Among cytokines, IL‐5 was remarkablyincreased in Peyer's patches, mesenteric lymph nodes, and mucosa involved in ileitis. Furthermore, infiltration of numerous eosinophils in ileitis was histologically evident. Severe combined immunodeficiency mice injected intraperitoneally with CD4+ cells from SAMP1/Yit mice developed colitis and ileitis, with the infiltration of eosinophils. Administration of anti‐IL‐5 antibodies significantly attenuated ileitis in these mice. We suggest that IL‐5 participates in the pathogenesis of ileitis and that anti‐IL‐5 antibodies are potentially useful for immunotherapy in CD patients. This is the first demonstration that IL‐5 is crucial for the development of ileitis in this mouse model of CD.
The First Cyclometallated (1‐Ferrocenylethanone thiosemicarbazone)palladium(II) Compounds − Crystal and Molecular Structure of [Pd{(η5‐C5H5)Fe(η5‐C5H3)C(Me)=NN=C(S)NHMe}(PPh3)]
Authors: Vila José M. , Gayoso Eduardo , Pereira M. Teresa , Ortigueira Juan M. , Alberdi Gemma , Mariño Marta , Alvarez Reyes , Fernández Alberto 
Published: May 2004

AbstractTreatment of the 1‐ferrocenylethanone thiosemicarbazone ligands (η5‐C5H5)Fe(η5‐C5H4)C(Me)=NN(H)C(=S)NHR [R = H (a), Me (b)] with K2[PdCl4] gave the novel heterometallic octanuclear palladium(II) compounds [Pd{(η5‐C5H5)Fe(η5‐C5H3)C(Me)=NN=C(S)NHR}]4 [R = H (1a), Me (1b)] as tetramers, after deprotonation of the NH group, with the ligands acting as terdentate donors through the [C,N,S] atoms. Treatment with nucleophiles cleaves the tetrameric clusters giving compounds in which splitting only of the Pd−Sbridging bonds has occurred. The strength of the Pd−Schelating bond hinders its cleavage. Thus, treatment of 1a or 1b with Ph2P(CH2)nPPh2 [n = 2 (dppe), 3 (dppp), 4 (dppb)] in a 1:2 molar ratio gave the tetranuclear species 2a−4a and 2b−4b, respectively, and treatment with PPh2R gave the dinuclear compounds 5a−7a and 5b−6b [R = Ph (5a, 5b), Et (6a, 6b), Me (7a)]. The complexes described are the first fully characterized cyclometallated palladium(II) complexes with 1‐ferrocenylethanone thiosemicarbazone ligands. The crystal and molecular structure of compound 5b have been determined by X‐ray crystallography. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
An Energy Dispersive X‐ray Diffraction Study of Dioxouranium(VI) in 1 M Lithium Citrate
Authors: Vasca Ermanno , Palladino Giuseppe , Manfredi Carla , Fontanella Cecilia , Sadun Claudia , Caminiti Ruggero 
Published: May 2004

AbstractAn Energy Dispersive X‐ray Diffraction (EDXD) study of 0.3 M dioxouranium(VI) in 1 M lithium citrate at pH = 5 is reported. The data are in accordance with the existence of a predominately polynuclear complex containing four U atoms, concluded from potentiometric measurements. The uranium atoms lie at the corners of two triangles sharing one edge. Five O atoms surround each uranyl group, the uranium coordination polyhedron being a pentagonal bipyramid; four U atoms are linked through double or single O bridges. The U−U distances are 3.95 Å and 4.65 Å. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
One‐Dimensional CdIICoordination Polymers: Solid Solutions with NiII, Thermal Stabilities and Structures
Authors: Vujovic Dejana , Raubenheimer Helgard G. , Nassimbeni Luigi R. 
Published: May 2004

AbstractReactions of Cd(NCS)2with 2‐, 3‐ and 4‐aminobenzonitrile ligands (2ABN, 3ABN and 4ABN respectively) have produced one‐dimensional chain polymers of the general formula [M(NCS)2(ABN)2]nwith the metal centres linked by double NCS−bridges. The three cadmium polymers [Cd(NCS)2(3ABN)2]n(1), [Cd(NCS)2(2ABN)2]n(2) and [Cd(NCS)2(4ABN)2]n(3) all differ in their hydrogen‐bonding patterns. In terms of ABN coordination, both1and2exhibit terminal amine coordination while in3the ABNs are coordinated through the cyano groups. Crystalline solid solutions of1of general formula [Cd1−xNix(NCS)2(3ABN)2]n, containing nickel and cadmium in varying proportions, have also been prepared in order to establish the influence of the metal ratio on the thermal stability and bonding parameters of the polymers. The coordination polymers are not good candidates for forming clathrates while their thermal stability (ranging between 147 and 244 °C) depends on the position of functional groups on the ABN ligands and on the Cd:Ni ratio in the solid solutions. The new polymers have been characterised by single crystal X‐ray diffraction, X‐ray powder diffraction, electron microscopy, infrared spectroscopy, thermogravimetry and differential scanning calorimetry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Synthesis and Structural Characterization of Monomeric Manganese(II) N‐Heterocyclic Carbene Complexes [MnX2(C{N(iPr)C(Me)}2)2] (X = Cl, I, and MeCOO)
Authors: Chai Jianfang , Zhu Hongping , Peng Ying , Roesky Herbert W. , Singh Sanjay , Schmidt Hans‐Georg , Noltemeyer Mathias 
Published: May 2004

AbstractReaction of MnCl2(THF)1.5, MnI2, or Mn(MeCOO)2 with two equivalents of N‐heterocyclic carbene [C(Me)N(iPr)]2C (1) in THF at room temperature readily afforded the corresponding carbene adducts [MnX2(C{N(iPr)C(Me)}2)2] [X = Cl (2); X = I (3); X = MeCOO (4)] in good yield. Solid‐state structural analysis of complexes 2−4 reveals that all complexes are monomeric. In complexes 2 and 3 the central manganese atoms are four coordinate and have a distorted tetrahedral geometry. The manganese atom in compound 4 has a coordination number of six and resides in a highly distorted octahedral geometry. The N‐heterocyclic carbene ligands in these complexes are coordinated differently to the central metal atoms. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Metal‐Directed Self‐Assembly: Two New Metal‐Binicotinate Grid Polymeric Networks and Their Fluorescence Emission Tuned by Ligand Configuration
Authors: Wu Benlai , Yuan Daqiang , Jiang Feilong , Wang Ruihu , Han Lei , Zhou Youfu , Hong Maochun 
Published: May 2004

AbstractTwo new 2‐D metal‐binicotinate coordination polymers, namely, [CdII(bpdc)]n (1) and {[ZnII8(bpdc)8(H2O)8](H2O)8}n (2) (H2bpdc = binicotinic acid) have been synthesized using hydrothermal and three‐layer diffusion methods, respectively. Single‐crystal X‐ray analyses revealed that both are extended grid networks of the (4,4) topology. Their structures alter with the configuration and function of bpdc. The achiral, free H2bpdc has axial chirality induced by metal coordination in 1, and bpdc connects to four metal centers forming a 2‐D (4,4) net with three kinds of apertures generated through self‐assembly. In 2, however, bpdc connects to three metal centers, fabricating a microporous framework containing hydrophilic channels. Studies on the solid emission spectra of the free ligand, 1, and 2 confirmed, that the configuration of bpdc resulting from metal‐directed coordination has a profound effect on the fluorescence emissions of 1 and 2. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Covalent Bonding of Phosphonates of L‐Proline and L‐Cysteine to γ‐Zirconium Phosphate
Authors: Huang Kunlin , Yu Jihong , Wang Guangmei , Li Yi , Xu Ruren 
Published: May 2004

AbstractThis paper describes the synthesis and characterization of γ‐zirconium phosphate‐phosphonates based on chiral N‐phosphonomethyl‐L‐proline [(−)‐HO3PCH2NHC4H7CO2H; H3PMP] from L‐proline, and N‐phosphonomethyl‐1,3‐thiazolidine‐4‐carboxylic acid [(−)‐HO3PCH2NHCH2SC2H3CO2H; H3PMTA] from L‐cysteine. Two compounds formulated as [Zr(PO4)(H2PO4)0.53(H2PMP)0.47·2.0H2O] [γ‐ZrPMP (1)] and [Zr(PO4)(H2PO4)0.50(H2PMT)0.50·1.6H2O] [γ‐ZrPMT (2)] were obtained by topotactic reaction of H3PMP and H3PMTA, respectively, with γ‐ZrP in the presence of water/acetone. They possess intercalation capabilities and optical activities. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Synthesis and Characterization of Ti Complexes Using 4‐tert‐Butyl‐2,6‐bis(hydroxymethyl)phenol: X‐ray Structures of a Confacial Bioctahedron with Terminal Nucleophilic Phenylmethoxide Ligands, and a Ti4O16 Core Protected by Two Hydrophobic Binding Pockets
Authors: Glaser Thorsten , Liratzis Ioannis , Lügger Thomas , Fröhlich Roland 
Published: May 2004

AbstractTreatment of 4‐tert‐butyl‐2,6‐bis(hydroxymethyl)phenol (H3L) with [TiO(acac)2] in protic solvents at elevated temperatures leads to the formation of the dinuclear complex (Et4N)[L3Ti2] 1, whereas carrying out the reaction at room temperature or in aprotic solvents leads to the formation of the tetranuclear complex (Et4N)2[L2(HL)4Ti4O2] 2. Heating 2 in protic solvents leads to the formation of 1, but 2 is stable in non‐protic solvents such as THF even upon heating. Dissolving 1 in an aprotic solvent leads to the formation of 2. The anion of 1 consists of a confacial bioctahedron with a [(BzO)3TiIV(μ2‐OPh)3TiIV(OBz)3]− core. The phenylmethoxide ligands (BzO−), and the phenolato ligands are bound to the strong Lewis acid TiIV. The bond lengths are for Ti−OBz ca. 1.83 Å and for Ti−μ2‐OPh ca. 2.11 Å. Despite the highly covalent Ti−OBz bond, the phenylmethoxide ligands exhibit nucleophilic character, and a tendency to bridge two TiIV ions as demonstrated by the synthesis of the tetranuclear complex 2. The dianion in 2 consists of a Ti4O16 core with two hydrophobic half‐bowl shaped pockets built from three tert‐butylbenzene units each. The hydrophobic pockets allow access to the Lewis basic μ3‐O2− ligands of the Ti4O16 core. In the crystal structure of 2·2CH3CN, two Et4N+ cations occupy these two binding pockets. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Novel Bonding Modes between Tetrathiafulvalenes (TTFs) and Transition Metal Centers: π‐Bonding and Covalent TTFSiMe2−MLn Coordination to Platinum
Authors: Jayaswal Mathuresh N. , Peindy Harmel N. , Guyon Fabrice , Knorr Michael , Avarvari Narcis , Fourmigué Marc 
Published: May 2004

AbstractTwo novel strategies for coordinating TTF to transition metal centers have been developed. The reaction of tetrathiafulvalene (TTF) or 3,4‐dimethyltetrathiafulvalene (o‐Me2TTF) with [Pt(η2‐C2H4)(PPh3)2] leads to the π complexes [Pt(η2‐TTF)(PPh3)2] (1) and [Pt(η2‐o‐Me2TTF)(PPh3)2] (2), respectively. An X‐ray crystallographic study performed on 2 confirmed, that TTFs act as a π acidic ligand. NMR studies revealed the existence, in solution, of an equilibrium between free and complexed TTF. Dilithiation of o‐Me2TTF and subsequent silylation with ClSiMe2H afforded 3,4‐dimethyl‐3′,4′‐(dimethylsilyl)tetrathiafulvalene (3), which has been structurally characterized. 3 reacts by oxidative addition across [Pt(η2‐C2H4)(PPh3)2] to give [Pt{η2‐o‐(SiMe2)2TTFMe2}(PPh3)2] (4), in which the TTF ligand is covalently ligated to platinum via SiMe2 bridges. The redox properties of 3 and 4 have been investigated by cyclic voltammetry. Strong cathodic shifts of the two redox processes were observed for 4, implying the TTF core. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)