bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared genetic architectures of educational attainment in East Asian and European populations
Authors: Chen Tzu-Ting , Kim Jaeyoung , Lam Max , Chuang Yi-Fang , Chiu Yen-Ling , Lin Shu-Chin , Jung Sang-Hyuk , Kim Beomsu , Kim Soyeon , Cho Chamlee , Shim Injeong , Park Sanghyeon , Ahn Yeeun , Okbay Aysu , Jang Hyemin , Kim Hee Jin , Seo Sang Won , Park Woong-Yang , Ge Tian , Huang Hailiang , Feng Yen-Chen Anne , Lin Yen-Feng , Myung Woojae , Chen Chia-Yen , Won Hong-Hee 
Published: January 2024

AbstractEducational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345). EduYears showed a high genetic correlation and power-adjusted transferability ratio between EAS and EUR. We also found similar functional enrichment, gene expression enrichment and cross-trait genetic correlations between two populations. Cross-ancestry fine-mapping identified refined credible sets with a higher posterior inclusion probability than single population fine-mapping. Polygenic prediction analysis in four independent EAS and EUR cohorts demonstrated transferability between populations. Our study supports the need for further research on diverse ancestries to increase our understanding of the genetic basis of educational attainment.
Bright and stable near-infrared lead-free perovskite light-emitting diodes
Authors: Yuan Fanglong , Folpini Giulia , Liu Tianjun , Singh Utkarsh , Treglia Antonella , Lim Jia Wei Melvin , Klarbring Johan , Simak Sergei I. , Abrikosov Igor A. , Sum Tze Chien , Petrozza Annamaria , Gao Feng 
Published: January 2024

AbstractLong-wavelength near-infrared light-emitting diodes (NIR LEDs) with peak emission wavelengths beyond 900 nm are of critical importance for various applications including night vision, biomedical imaging, sensing and optical communications. However, the low radiance and poor operational stability of state-of-the-art long-wavelength NIR LEDs based on soft materials remain the most critical factors limiting their practical applications. Here we develop NIR LEDs emitting beyond 900 nm with improved performance through the rational manipulation of p doping in all-inorganic tin perovskites (CsSnI3) by retarding and controlling the crystallization process of perovskite precursors in tin-rich conditions. The resulting NIR LEDs exhibit a peak emission wavelength at 948 nm, high radiance of 226 W sr−1 m−2 and long operational half-lifetime of 39.5 h at a high constant current density of 100 mA cm−2. Our demonstration of efficient and stable NIR LEDs operating at high current densities may also open up new opportunities towards electrically pumped lasers.
Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults
Authors: Ravichandran Sathyabaarathi , Erra-Diaz Fernando , Karakaslar Onur E. , Marches Radu , Kenyon-Pesce Lisa , Rossi Robert , Chaussabel Damien , Nehar-Belaid Djamel , LaFon David C. , Pascual Virginia , Palucka Karolina , Paust Silke , Nahm Moon H. , Kuchel George A. , Banchereau Jacques , Ucar Duygu 
Published: January 2024

AbstractPneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunological responses and baseline predictors remain unknown. We vaccinated 39 older adults (>60 years) with PPSV23 or PCV13 and observed comparable antibody responses (day 28) and plasmablast transcriptional responses (day 10); however, the baseline predictors were distinct. Analyses of baseline flow cytometry and bulk and single-cell RNA-sequencing data revealed a baseline phenotype specifically associated with weaker PCV13 responses, which was characterized by increased expression of cytotoxicity-associated genes, increased frequencies of CD16+ natural killer cells and interleukin-17-producing helper T cells and a decreased frequency of type 1 helper T cells. Men displayed this phenotype more robustly and mounted weaker PCV13 responses than women. Baseline expression levels of a distinct gene set predicted PPSV23 responses. This pneumococcal precision vaccinology study in older adults uncovered distinct baseline predictors that might transform vaccination strategies and initiate novel interventions.
Magnesium–ibogaine therapy in veterans with traumatic brain injuries
Authors: Cherian Kirsten N. , Keynan Jackob N. , Anker Lauren , Faerman Afik , Brown Randi E. , Shamma Ahmed , Keynan Or , Coetzee John P. , Batail Jean-Marie , Phillips Angela , Bassano Nicholas J. , Sahlem Gregory L. , Inzunza Jose , Millar Trevor , Dickinson Jonathan , Rolle C. E. , Keller Jennifer , Adamson Maheen , Kratter Ian H. , Williams Nolan R. 
Published: January 2024

AbstractTraumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional impairments and psychiatric syndromes such as post-traumatic stress disorder (PTSD), depression and anxiety. Special Operations Forces (SOF) veterans (SOVs) may be at an elevated risk for these complications, leading some to seek underexplored treatment alternatives such as the oneirogen ibogaine, a plant-derived compound known to interact with multiple neurotransmitter systems that has been studied primarily as a treatment for substance use disorders. Ibogaine has been associated with instances of fatal cardiac arrhythmia, but coadministration of magnesium may mitigate this concern. In the present study, we report a prospective observational study of the Magnesium–Ibogaine: the Stanford Traumatic Injury to the CNS protocol (MISTIC), provided together with complementary treatment modalities, in 30 male SOVs with predominantly mild TBI. We assessed changes in the World Health Organization Disability Assessment Schedule from baseline to immediately (primary outcome) and 1 month (secondary outcome) after treatment. Additional secondary outcomes included changes in PTSD (Clinician-Administered PTSD Scale for DSM-5), depression (Montgomery–Åsberg Depression Rating Scale) and anxiety (Hamilton Anxiety Rating Scale). MISTIC resulted in significant improvements in functioning both immediately (Pcorrected < 0.001, Cohen’sd = 0.74) and 1 month (Pcorrected < 0.001,d = 2.20) after treatment and in PTSD (Pcorrected < 0.001,d = 2.54), depression (Pcorrected < 0.001,d = 2.80) and anxiety (Pcorrected < 0.001,d = 2.13) at 1 month after treatment. There were no unexpected or serious adverse events. Controlled clinical trials to assess safety and efficacy are needed to validate these initial open-label findings. ClinicalTrials.gov registration:NCT04313712.
Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial
Authors: Heinrich Michael C. , Jones Robin L. , George Suzanne , Gelderblom Hans , Schöffski Patrick , von Mehren Margaret , Zalcberg John R. , Kang Yoon-Koo , Razak Albiruni Abdul , Trent Jonathan , Attia Steven , Le Cesne Axel , Siontis Brittany L. , Goldstein David , Boye Kjetil , Sanchez Cesar , Steeghs Neeltje , Rutkowski Piotr , Druta Mihaela , Serrano César , Somaiah Neeta , Chi Ping , Reichmann William , Sprott Kam , Achour Haroun , Sherman Matthew L. , Ruiz-Soto Rodrigo , Blay Jean-Yves , Bauer Sebastian 
Published: January 2024

AbstractINTRIGUE was an open-label, phase 3 study in adult patients with advanced gastrointestinal stromal tumor who had disease progression on or intolerance to imatinib and who were randomized to once-daily ripretinib 150 mg or sunitinib 50 mg. In the primary analysis, progression-free survival (PFS) with ripretinib was not superior to sunitinib. In clinical and nonclinical studies, ripretinib and sunitinib have demonstrated differential activity based on the exon location of KIT mutations. Therefore, we hypothesized that mutational analysis using circulating tumor DNA (ctDNA) might provide further insight. In this exploratory analysis (N = 362), baseline peripheral whole blood was analyzed by a 74-gene ctDNA next-generation sequencing–based assay. ctDNA was detected in 280/362 (77%) samples with KIT mutations in 213/362 patients (59%). Imatinib-resistant mutations were found in the KIT ATP-binding pocket (exons 13/14) and activation loop (exons 17/18). Mutational subgroup assessment showed 2 mutually exclusive populations with differential treatment effects. Patients with only KIT exon 11 + 13/14 mutations (ripretinib, n = 21; sunitinib, n = 20) had better PFS with sunitinib versus ripretinib (median, 15.0 versus 4.0 months). Patients with only KIT exon 11 + 17/18 mutations (ripretinib, n = 27; sunitinib, n = 25) had better PFS with ripretinib versus sunitinib (median, 14.2 versus 1.5 months). The results of this exploratory analysis suggest ctDNA sequencing may improve the prediction of the efficacy of single-drug therapies and support further evaluation of ripretinib in patients with KIT exon 11 + 17/18 mutations. ClinicalTrials.gov identifier: NCT03673501.
Women’s neuroplasticity during gestation, childbirth and postpartum
Authors: Paternina-Die María , Martínez-García Magdalena , Martín de Blas Daniel , Noguero Inés , Servin-Barthet Camila , Pretus Clara , Soler Anna , López-Montoya Gonzalo , Desco Manuel , Carmona Susana 
Published: January 2024

AbstractPregnancy is a unique neuroplastic period in adult life. This longitudinal study tracked brain cortical changes during the peripartum period and explored how the type of childbirth affects these changes. We collected neuroanatomic, obstetric and neuropsychological data from 110 first-time mothers during late pregnancy and early postpartum, as well as from 34 nulliparous women evaluated at similar time points. During late pregnancy, mothers showed lower cortical volume than controls across all functional networks. These cortical differences attenuated in the early postpartum session. Default mode and frontoparietal networks showed below-expected volume increases during peripartum, suggesting that their reductions may persist longer. Results also pointed to different cortical trajectories in mothers who delivered by scheduled C-section. The main findings were replicated in an independent sample of 29 mothers and 24 nulliparous women. These data suggest a dynamic trajectory of cortical decreases during pregnancy that attenuates in the postpartum period, at a different rate depending on the brain network and childbirth type.
Online monitoring of phytate content in plant residuals during wet-treatment
Authors: Widderich Niklas , Bubenheim Paul , Liese Andreas 
Published: January 2024

AbstractThe occurrence of organically bound phosphorus (P) as phytate in plant-based feeding material is a challenge for livestock farming due to limited utilization during the digestion by the animal. Its excretion into the environment through the manure pathway, poses a challenge, due to increased eutrophication and restrictions for P. Hence, while the routine supplementation of phytase enzymes in monogastric diets is common practice, metabolically triggering endogenous plant enzymes by wet-treatment prior to feeding can also lead to a better utilization of phytate bound P and increased digestibility by the animal. Nonetheless, traditional quantification of residual phytate content in plant material is both labor- and chemical-intense. The aim of this study is, therefore, to predict the remaining phytate content during wet-treatment through a straightforward and flexible methodological approach based on real-time analysis. For this, rye bran is used as a model substrate. A partial least squares regression algorithm relates the infrared spectra to the concentrations and predict the amount of P species that are transferred from the bran matrix to the liquid phase. By applying a mass balance for P and considering the effect of water compression, the amount of residual phytate content in rye bran at different time points of wet-treatment is determined. Results are compared to wet chemical methods, resulting in a RMSEP of 0.28 gphytate∙100 gbran−1. In addition, the study demonstrates the feasibility of this approach and provides insights into phytate degradation in plant residuals. The method holds the potential for further applications for the screening and investigation of feed material conditioning and also offers the possibility to employ various real-time analytical techniques for assessing phytate remnants in biological samples during wet-treatment.
Effect of heating insufflation tube of AirSeal system on laparoscopic surgery
Authors: Yoshimatsu Gumpei , Sahara Kurumi , Ohno Ryo , Kajitani Ryuji , Munechika Taro , Matsumoto Yoshiko , Nagano Hideki , Watanabe Toshifumi , Aisu Naoya , Yoshida Yoichiro , Hasegawa Suguru 
Published: January 2024

AbstractThe AirSeal system (CONMED, NY, USA) can outstandingly keep pneumoperitoneum stable. However, water droplets form on the access port, impairing the performance of comfortable surgical procedures because of the resultant wet surgical field. This study was performed to clarify the mechanism of water droplet formation and to prevent it. Condensation was observed on the AirSeal system. A heater was wrapped around the tri-lumen tube, and the heating effect was assessed. The simulator experiments revealed that condensation formed in the tri-lumen tube and on the wall of the access port. The accumulated weight of the condensation on the wall of the access port was 41.6 g in the Heated group, 138.2 g in the Control group, and 479.4 g in the Cooled group. In the clinical assessment, the accumulated volume of the condensation attached to the inside wall was significantly smaller in the Heated group than in the Unheated group (111.7 g vs. 332.9 g, respectively). We clarified that the volume of condensation attached to the wall of the access port depended on the temperature of the tri-lumen tube. The clinical study revealed that the condensation on the access port was reduced by heating the tri-lumen tube. The development of a novel heating device for the insufflation tube would be effective and useful.
Polymeric coating doped with nanomaterials for functional impact on different substrates
Authors: Shahzadi Phool , Majeed Muhammad Amjad , Ibrahim Saba , Asif Sabahat , Kalsoom Razia , Hussain Irshad 
Published: January 2024

AbstractMicroorganism contamination on substrate surfaces is arousing increasingly concern as a serious health issue. In this research work, antimicrobial water-based acrylic paint containing silver nanoparticles (Ag NPs) was prepared using the facile Ag+ in situ reduction process, in which AgNO3 and reducing agent sodium acrylate were refluxed with acrylic polymeric solution to obtain an antimicrobial and antifungal polymeric material for substrate coating. The Synthesized antimicrobial and antifungal water-based acrylic paint were characterized by different spectroscopic techniques. The FTIR and UV–Visible spectroscopic analyses were investigated to study the water-based acrylic paint structure as well as the significant impact of Ag NPs on the paint matrix. The UV–Visible and FTIR Spectra peak shows successful integration of Ag NPs within the polymer matrix without altering the core functional groups of the paint. The water based acrylic paint exhibited a strong antimicrobial activity, revealed substantial inhibition zones against all four strains of Gram negative represented by Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae and Gram-positive represented by Bacillus cereus. The coated film on substrate also shows great inhibition zone which exhibit a strong antimicrobial activity. Moreover, water based acrylic paint also exhibited a great antifungal activity, revealed substantial zone of inhibition against the Aspergillus niger, Aspergillus terreus and Rhizopus arrhizus fungal strains. Also, the coated film showed the best adhesion at 50% and 80% solution of polymeric coating sample as compared to pure or very dilute sample coating. This innovative approach has the potential to revolutionize varies industries from healthcare to construction.
Giving people the words to say no leads them to feel freer to say yes
Authors: Schlund Rachel , Sommers Roseanna , Bohns Vanessa K. 
Published: January 2024

AbstractWe examine how to structure requests to help people feel they can say no (or yes) more voluntarily. Specifically, we examine the effect of having the requester provide the request-target with an explicit phrase they can use to decline requests. Part of the difficulty of saying no is finding the words to do so when put on the spot. Providing individuals with an explicit script they can use to decline a request may help override implicit scripts and norms of politeness that generally dictate compliance. This should make individuals feel more comfortable refusing requests and make agreement feel more voluntary. Hence, we hypothesized that telling people how to say no (by providing them with an explicit script) would make compliance decisions feel more voluntary above and beyond merely telling them they can say no. Across two experimental lab studies (N = 535), we find support for this prediction.
A comparative study of fracture conductivity prediction using ensemble methods in the acid fracturing treatment in oil wells
Authors: Kharazi Esfahani Parsa , Akbari Mohammadreza , Khalili Yasin 
Published: January 2024

AbstractThe study of acid fracture conductivity stands as a pivotal aspect of petroleum engineering, offering a well-established technique to amplify production rates in carbonate reservoirs. This research delves into the intricate dynamics influencing the conductivity of acid fractures, particularly under varying closure stresses and in diverse rock formations. The conductivity of acid fractures is intricately interconnected with the dissolution of rock, etching patterns on fracture surfaces, rock strength, and closure stress. To accurately predict fracture conductivity under different closure stresses, a robust model is necessary. This model involves assessing both the baseline fracture conductivity under zero closure stress and the rate of conductivity variation as closure stress fluctuates. Key among the influential factors affecting fracture conductivity is the type of rock within the reservoir. Understanding and predicting the behavior of different formations under disparate closure stresses poses a significant challenge, as does deciphering the diverse effects of treatment parameters such as acid injection rate and strength on fracture conductivity. In this study, the predictive power of XGBoost, a machine learning algorithm, was explored in assessing acid fracture conductivity in dolomite and limestone formations. The findings revealed XGBoost's ability to outperform previous studies in predicting fracture conductivity in both types of formations. Notably, it exhibited superior accuracy in forecasting fracture conductivity under varying treatment conditions, underscoring its robustness and versatility. The research underscores the pivotal role of closure stress, dissolution rate of rock (DREC), and rock strength in influencing fracture conductivity. By integrating these parameters into the design of acid fracturing operations, accurate predictions can be achieved, allowing for the optimization of treatment designs. This study illuminates the potential of XGBoost in optimizing acid fracturing treatments, ultimately bolstering well productivity in carbonate reservoirs. Furthermore, it advocates for the essential nature of separate modeling and analysis based on rock types to comprehend and optimize fracturing processes. The comparison between dolomite and limestone formations unveiled distinct conductivity behaviors, underlining the significance of tailored analyses based on rock type for precise operational optimization.
Climatic comparison of surface urban heat island using satellite remote sensing in Tehran and suburbs
Authors: Zargari Motahhareh , Mofidi Abbas , Entezari Alireza , Baaghideh Mohammad 
Published: January 2024

AbstractIn this study, we aim to compare the climatic conditions of Surface Urban Heat Island (SUHI) in Tehran and its suburbs using day/night time data from three satellites. A high-resolution Land Surface Temperature (LST) data from MODIS Aqua, Sentinel-3, and Landsat 8 were selected to facilitate this study. The highest values of LST/UHI are observed in downtown Tehran and suburban areas at night. The temperature difference also shows an increase at night in Tehran and the western suburbs, while it decreases during the day. When comparing LST/UHI with altitude in different directions, it is found that urban areas and the south, southeast, southwest, and west suburban areas experience higher temperatures at night. MODIS LST products are more appropriate for checking nighttime SUHI in Tehran's Great area in comparison to other products. Moran's I indicates that the highest positive values occur during seasonal and annual periods at night. The Getis index demonstrates a consistent pattern across all seasons, and this trend persists throughout the year. The seasonal and annual UHI difference between Tehran and its suburbs is 5 °C. The LST diagram reveals that higher temperatures occur during warm months. The temporal NDVI distribution indicates lower NDVI values from June to February and summer to winter. The spatial distribution shows that due to the lack of NDVI index in urban areas, LST/UHI values are higher at night in Tehran compared to the suburbs. UHI is not limited to urban areas but has also spread beyond the city borders. As a result, the highest UHI values are found in downtown Tehran and its southeast, south, southwest, and west suburbs.
Blood and MRI biomarkers of mild traumatic brain injury in non-concussed collegiate football players
Authors: Cho Eunhan , Granger Joshua , Theall Bailey , Lemoine Nathan , Calvert Derek , Marucci Jack , Mullenix Shelly , O’Neal Hollis , Jacome Tomas , Irving Brian A. , Johannsen Neil M. , Carmichael Owen , Spielmann Guillaume 
Published: January 2024

AbstractFootball has one of the highest incidence rates of mild traumatic brain injury (mTBI) among contact sports; however, the effects of repeated sub-concussive head impacts on brain structure and function remain under-studied. We assessed the association between biomarkers of mTBI and structural and functional MRI scans over an entire season among non-concussed NCAA Division I linemen and non-linemen. Concentrations of S100B, GFAP, BDNF, NFL, and NSE were assessed in 48 collegiate football players (32 linemen; 16 non-linemen) before the start of pre-season training (pre-camp), at the end of pre-season training (pre-season), and at the end of the competitive season (post-season). Changes in brain structure and function were assessed in a sub-sample of 11 linemen and 6 non-linemen using structural and functional MRI during the execution of Stroop and attention network tasks. S100B, GFAP and BDNF concentrations were increased at post-season compared to pre-camp in linemen. White matter hyperintensities increased in linemen during pre-season camp training compared to pre-camp. This study showed that the effects of repeated head impacts are detectable in the blood of elite level non-concussed collegiate football players exposed to low-moderate impacts to the heads, which correlated with some neurological outcomes without translating to clinically-relevant changes in brain anatomy or function.