bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile exfoliation of natural silk nanofibrils for homogeneous reinforced composites
Authors: He Li , Huang Renyan , Hua Jiahui , Wang Jiannan , You Renchuan , Yan Shuqin , Zhang Qiang 
Published: December 2023

AbstractRegenerated silk fibroin (SF) as a biomaterial has attracted increasing attention due to its outstanding biocompatibility and processibility. However, it faces great challenges in practical application because of the deterioration of the intrinsic mechanical properties of natural silk during the regeneration process. Natural silk nanofibrils (SNFs) has a typical hierarchical structure and maintains excellent mechanical properties of natural silk. Based on principle of homogeneous reinforced composites, herein, the SNFs were isolated as a reinforcing material and regenerated SF as matrix material to fabricate high‐performance SF nanocomposites. The SNFs with diameters ranging from 100 to 600 nm were prepared with yields of 87%. They not only maintained the crystallinity of natural silk, but also remained high stability in acid and alkaline solutions. Thanks to homogenous reinforcement of the SNFs, the tensile stress of the reinforced film was up to 2.2 MPa, the strain was 129%, and the water absorption was 50% in wet state. In vitro, the reinforced films supported adhesion and proliferation of human umbilical vein endothelial cells, which has potential in the application of biomedical dressings.Highlights
Natural silk nanofibrils (SNFs) were exfoliated using a facile approach.
The SNFs reinforced the silk nanocomposites significantly.
The silk nanocomposites showed remarkable cytocompatibility.
Homogeneous reinforcement is useful strategy to fabricate nanocomposites.
The need for open and FAIR data in top‐down proteomics
Authors: Lermyte Frederik 
Published: December 2023

AbstractIn recent years, there has been a tremendous evolution in the high‐throughput, tandem mass spectrometry‐based analysis of intact proteins, also known as top‐down proteomics (TDP). Both hardware and software have developed to the point that the technique has largely entered the mainstream, and large‐scale, ambitious, multi‐laboratory initiatives have started to make their appearance in the literature. For this, however, more convenient and robust data sharing and reuse will be required. Walzer et al. have created TopDownApp, a customisable, open platform for visualisation and analysis of TDP data, which they hope will be a step in this direction. As they point out, other benefits of such data sharing and interoperability would include reanalysis of published datasets, as well as the prospect of using large amounts of data to train machine learning algorithms. In time, this work could prove to be a valuable resource in the move towards a future of greater TDP data findability, accessibility, interoperability and reusability.
Sleep disturbances in patients with cirrhosis: Pursuing just right
Authors: Hui Yangyang , Chen Xin , Sun Chao 
Published: December 2023

AbstractLiver cirrhosis represents the end‐stage of chronic liver disease and is related to high morbidity and mortality. To date, there is no standard curative method for liver cirrhosis, but there is treatment for common complications. Therefore, improving the health‐related quality of life (HRQoL) of patients with cirrhosis has become a potential therapeutic intervention by limiting its symptoms and complications. Sleep is a complex and rhythmic physiological process and is crucial to human health. Sleep disturbances are commonly encountered in patients with cirrhosis and adversely affect their HRQoL. Recently, sleep disturbances in patients with cirrhosis have received growing attention owing to their reciprocal effects. To better understand the effect of sleep disturbances on patients with cirrhosis, this review provides a comprehensive summary of the epidemiology and underlying mechanisms of sleep disturbances in cirrhosis. We also elaborate on the mutual relationships between sleep disturbances and other complications, such as muscle cramps, malnutrition, frailty, sarcopenia, HRQoL, and hepatic encephalopathy, in the context of cirrhosis. Finally, we discuss the potential management to improve poor sleep quality in patients with cirrhosis.
Pediatric long‐term noninvasive respiratory support in children with central nervous system disorders
Authors: Carrara Marion , Aubertin Guillaume , Khirani Sonia , Massenavette Bruno , Bierme Priscille , Griffon Lucie , Ioan Iulia , Schweitzer Cyril , Binoche Alexandra , Lampin Marie‐Emilie , Mordacq Clémence , Rubinsztajn Robert , Debeilleix Stéphane , Galode François , Bui Stéphanie , Hullo Eglantine , Becourt Arnaud , Lubrano Marc , Moreau Johan , Renoux Marie‐Catherine , Matecki Stefan , Stremler Nathalie , Baravalle‐Einaudi Melisande , Mazenq Julie , Sigur Elodie , Labouret Géraldine , Genevois Anne‐Laure , Heyman Rachel , Pomedio Michael , Masson Alexandra , Hangard Pauline , Menetrey Céline , Le Clainche Laurence , Bokov Plamen , Dudoignon Benjamin , Fleurence Emmanuelle , Bergounioux Jean , Mbieleu Blaise , Breining Audrey , Giovannin‐Chami Lisa , Fina Agnes , Ollivier Morgane , Gachelin Elsa , Perisson Caroline , Pervillé Anne , Barzic Audrey , Cros Pierrick , Jokic Mickaël , Labbé Guillaume , Diaz Véronique , Coutier Laurianne , Fauroux Brigitte , Taytard Jessica 
Published: December 2023

AbstractRationaleThe use of long‐term noninvasive respiratory support is increasing in children along with an extension of indications, in particular in children with central nervous system (CNS) disorders.ObjectiveThe aim of this study was to describe the characteristics of children with CNS disorders treated with long‐term noninvasive respiratory support in France.MethodsData were collected from 27 French pediatric university centers through an anonymous questionnaire filled for every child treated with noninvasive ventilatory support ≥3 months on 1st June 2019.Main ResultsThe data of 182 patients (55% boys, median age: 10.2 [5.4;14.8] years old [range: 0.3–25]) were collected: 35 (19%) patients had nontumoral spinal cord injury, 22 (12%) CNS tumors, 63 (35%) multiple disabilities, 26 (14%) central alveolar hypoventilation and 36 (20%) other CNS disorders. Seventy five percent of the patients were treated with noninvasive ventilation (NIV) and 25% with continuous positive airway pressure (CPAP). The main investigations performed before CPAP/NIV initiation were nocturnal gas exchange recordings, alone or coupled with poly(somno)graphy (in 29% and 34% of the patients, respectively). CPAP/NIV was started in an acute setting in 10% of the patients. Median adherence was 8 [6;10] hours/night, with 12% of patients using treatment <4 h/day. Nasal mask was the most common interface (70%). Airway clearance techniques were used by 31% of patients.ConclusionCPAP/NIV may be a therapeutic option in children with CNS disorders. Future studies should assess treatment efficacy and patient reported outcome measures.
Management of endocrinological problems in children on home invasive mechanical ventilation
Authors: Şiklar Zeynep 
Published: December 2023

AbstractObjectiveChildren with home invasive mechanical ventilation (HIMV) face numerous difficulties, including endocrine problems that can arise as a consequence of their condition. Endocrine problems seen in children treated with HIMV may develop due to the underlying disease, drugs used, or prolonged mechanical ventilation.MethodThis manuscript will review the most common endocrine problems encountered in children with HIMV, including problems in glucose metabolism, thyroid dysfunction, bone metabolism, adrenal dysfunctions, growth, and puberty.ConclusionClose monitoring, multidisciplinary care, and regular assessments are essential to optimize the endocrine system functions of children requiring home mechanical ventilation. By understanding these complications, it can develop effective management strategies to optimize the health and well‐being of these vulnerable individuals.
UXO and environmental risk factors impacting EOD operations in German waters**
Authors: Frey Torsten 
Published: December 2023

AbstractThis article presents risk factors that are associated with the handling of unexploded ordnance (UXO) during explosive ordnance disposal (EOD) operations in German waters. The construction of offshore wind parks and the German immediate action program are expected to increase the number of EOD operations. Existing literature and guidelines do not offer a structured and reproducible framework for assessing EOD risk. To fill this gap, a network of EOD risk factors was developed by means of a literature review and validation via expert consultation. The study was scoped to “personnel and equipment at the EOD location” as the risk receptor and “undesired detonation” as the undesired event under investigation. Factors are subdivided into UXO factors that depend on the object that should be handled and factors that describe the object's surrounding environment. While the former can be researched by an EOD expert, the latter must be measured on site or acquired from a model. Each of these factors contributes to risk, some directly and others indirectly via other factors. The complexity of the resulting network, with its 33 factors, demonstrates the need for a reliable and reproducible model to quantify EOD risk. Its purpose is not to replace EOD experts but to aid them in their decision‐making process. Such a tool can provide valuable support for the high‐cost and high‐risk EOD operations.
Identification of aggregation pheromones released by the stick tea thrips (Dendrothrips minowai) larvae and their application for controlling thrips in tea plantations
Authors: Xiu Chunli , Pan Hongsheng , Zhang Fengge , Luo Zongxiu , Bian Lei , Li Zhaoqun , Fu Nanxia , Zhou Li , Magsi Fida Hussain , Cai Xiaoming , Chen Zongmao 
Published: December 2023

AbstractBACKGROUNDThe stick tea thrips, Dendrothrips minowai Priesner, is one of the most important sucking pests that seriously infest tea plants (Camellia sinensis) in China. Given that D. minowai exhibit aggregation behaviors in tea plantations, this study evaluated the potential of aggregation pheromones for their control.RESULTSH‐tube olfactometer assays showed that D. minowai larvae, adult females and adult males were significantly attracted to larvae rather than adult females and males under laboratory conditions. Subsequent gas chromatography–mass spectrometry analysis of volatiles from larvae, identified two larva‐specific components: dodecyl acetate and tetradecyl acetate. Electrophysiological and behavioral experiments confirmed the positive response of females and males to dodecyl acetate, tetradecyl acetate, and their blend (1:1.5). Deployment of these aggregation pheromones on sticky traps resulted in a 1.2‐ to 3.0‐fold increase in the capture of D. minowai adults compared with control traps. In addition, deployment of sticky traps baited with these aggregation pheromones within tea plantations resulted in a noteworthy reduction in the population of adult thrips per 100 leaves, 10 days following trap deployment. The reduction ranged from 29% to 59%, in comparison with the control.CONCLUSIOND. minowai larvae produce aggregation pheromones, dodecyl acetate and tetradecyl acetate, that can be useful for controlling tea thrips. © 2023 Society of Chemical Industry.
Tumor growth inhibition modeling in patients with second line biliary tract cancer and first line non‐small cell lung cancer based on bintrafusp alfa trials
Authors: Milenković‐Grišić Ana‐Marija , Terranova Nadia , Mould Diane R. , Vugmeyster Yulia , Mrowiec Thomas , Machl Andreas , Girard Pascal , Venkatakrishnan Karthik , Khandelwal Akash 
Published: December 2023

AbstractThis analysis aimed to quantify tumor dynamics in patients receiving either bintrafusp alfa (BA) or pembrolizumab, by population pharmacokinetic (PK)‐pharmacodynamic modeling, and investigate clinical and molecular covariates describing the variability in tumor dynamics by pharmacometric and machine‐learning (ML) approaches. Data originated from two clinical trials in patients with biliary tract cancer (BTC; NCT03833661) receiving BA and non‐small cell lung cancer (NSCLC; NCT03631706) receiving BA or pembrolizumab. Individual drug exposure was estimated from previously developed population PK models. Population tumor dynamics models were developed for each drug‐indication combination, and covariate evaluations performed using nonlinear mixed‐effects modeling (NLME) and ML (elastic net and random forest models) approaches. The three tumor dynamics’ model structures all included linear tumor growth components and exponential tumor shrinkage. The final BTC model included the effect of drug exposure (area under the curve) and several covariates (demographics, disease‐related, and genetic mutations). Drug exposure was not significant in either of the NSCLC models, which included two, disease‐related, covariates in the BA arm, and none in the pembrolizumab arm. The covariates identified by univariable NLME and ML highly overlapped in BTC but showed less agreement in NSCLC analyses. Hyperprogression could be identified by higher tumor growth and lower tumor kill rates and could not be related to BA exposure. Tumor size over time was quantitatively characterized in two tumor types and under two treatments. Factors potentially related to tumor dynamics were assessed using NLME and ML approaches; however, their net impact on tumor size was considered as not clinically relevant.
High Rate, Dendrite Free Lithium Metal Batteries of Extended Cyclability via a Scalable Separator Modification Approach
Authors: Yadav Preeti , Thakur Pallavi , Maity Dipak , Narayanan Tharangattu N. 
Published: December 2023

AbstractOwing to their great promise of high energy density, the development of safer lithium metal batteries (LMBs) has become the necessity of the hour. Herein, a scalable method based on conventional Celgard membrane (CM) separator modification is adopted to develop high‐rate (10 mA cm‒2) dendrite‐free LMBs of extended cyclability (>1000 hours, >1500 cycles with 3 mA cm‒2, the bare fails within 50 cycles) with low over potential losses. The CM modification method entails the deposition of thin coatings of (≈6.6 µm) graphitic fluorocarbon (FG) via a large area electrophoretic deposition, where it helps for the formation of a stable LiF and carbon rich solid electrolyte interface (SEI) aiding a uniform lithium deposition even in higher fluxes. The FG@CM delivers a high transport number for Li ion (0.74) in comparison to the bare CM (0.31), indicating a facile Li ion transport through the membrane. A mechanistic insight into the role of artificial SEI formation with such membrane modification is provided here with a series of electrochemical as well as spectroscopic in situ/ex situ and postmortem analyses. The simplicity and scalability of the technique make this approach unique among other reported ones towards the advancement of safer LMBs of high energy and power density.
TheGeneral Crack Component Modelfor reversed cyclic shear
Authors: Ruggiero David M. , Bentz Evan C. , Calvi Gian Michele , Collins Michael P. 
Published: December 2023

AbstractA growing body of research has shown that reversed cyclic shear loading of reinforced concrete (RC) causes effects that are not accounted for in monotonic behavioral models. Notable among these effects are a reduction in shear strength and significant plastic offsets. This paper presents the General Crack Component Model, a rational, mechanics‐based model that explicitly considers the constitutive behavior of cracks in RC. Cracked RC is treated as a series–parallel system of bonded and unbonded regions, where the crack interfaces have both crack closing hysteresis and a kinematic contact constraint. Validation was performed using data from monotonic and reversed cyclic experiments on panel elements, and has shown that this analytical model is able to accurately capture the salient features of reversed cyclic shear behavior.
Experimental and numerical study on eccentric compression performance of partially encased composite columns with corrugated web
Authors: Wang Wei , Cai Hengli , Bai Congyou , Bao Haiyang , Gao Boyuan , Yuan Zhiwei , Niu Jianhui 
Published: December 2023

SummaryPartially encased composite (PEC) members are becoming increasingly popular because of their high strength and suitability for prefabrication and assembly. Corrugated steel plate has higher out‐of‐plane stiffness than flat steel plate. When it is combined with concrete, the bonding between corrugated steel plate and concrete is more obvious than that between flat steel plate and concrete. For this reason, a new type of corrugated web PEC column (CPEC column) was proposed in this paper, and its eccentric compression performance was studied by experiment and numerical method. Nine specimens were tested, of which two were subjected to axial compression and seven were subjected to eccentric compression. The key factors considered in the experiment were the loading direction, load eccentricity, link spacing, and width‐to‐thickness ratio of flange. A three‐dimensional finite element model of the CPEC columns was established and verified, and the influence of the wave angle of corrugated web on the behavior of CPEC columns under eccentric compression was investigated using a parametric study. Finally, the current design codes for estimating the interaction curve and bearing capacity of CPEC columns were assessed.
Climate catastrophe: The value of envisioning the worst‐case scenarios of climate change
Authors: Davidson Joe P. L. , Kemp Luke 
Published: December 2023

AbstractMany now argue that we should think about the previously unthinkable risks of climate change, including societal collapses and human extinction. Calamitous images of the future are not pathological or counterproductive: it is both necessary and valuable to imagine the worst‐case scenarios of climate change. Critics of climate catastrophe often group together all visions of disastrous futures under labels like doomism or pessimism. This is unhelpful and greater nuance is required. We need to distinguish between climate doomists (who see catastrophe as imminent and unavoidable) and climate risk realists (who see catastrophe as one potential future that should be avoided). We also need to split apart the different ways of envisioning climate catastrophe to understand their distinct strengths and weaknesses. We outline and compare three alternative modes of viewing the worst‐case scenarios of climate change: foresight, agitation, and fiction. The first centers on modeling catastrophic climate scenarios, the second on the use of images of climate catastrophe for political action, and the third on fictional visions of future climate disasters. These different approaches are complementary and should be better integrated to create more comprehensive models of the future. All of them would benefit from viewing the future as uncertain, reflecting on the social position of the author, and guarding against the authoritarian “stomp reflex” that can be induced by discussions of crisis and emergency.This article is categorized under:Assessing Impacts of Climate Change > Evaluating Future Impacts of Climate ChangePerceptions, Behavior, and Communication of Climate Change > Perceptions of Climate ChangeClimate, History, Society, Culture > Ideas and Knowledge
Augmented Nature-Based Solutions: A Possible Taxonomy of Technologies “in” and “for” Urban Greening Strategies
Authors: Mahmoud Israa , Morello Eugenio , Bisello Adriano , Kolokotsa Dionysia 
Published: December 2023

AbstractThe conceptualization and application of nature-based solutions (NBS) in the practice of planning and projects on urban and architectural scales have reached a level of maturity in the last 10 years, thanks to a strong push from European policies and funding for European projects and evidence from scientific literature. However, a systemic insight into the role of technology in supporting the spread of NBS has not yet been developed. The role of technology is understood here as fundamental to the very core concept of NBS, i.e., engineering solutions that integrate technological aspects to effectively increase nature’s potential. The authors, therefore, propose an investigation into the various opportunities offered by technology integrated “into” greenery and used “for” promoting greenery, based on the experience of two European Horizon 2020 projects, CLEVER Cities and VARCITIES, and from the application cases presented during the dedicated track at the SSPCR 2022 conference.
A Holistic Sustainability Evaluation of Positive Energy Districts—Planetary Boundaries Framing the Transformation of Districts
Authors: Haase Matthias , Baer Daniela 
Published: December 2023

AbstractThe development of districts requires a distinct understanding of the current situation as well as a vision of future districts to be able to develop suitable pathways for a sustainable transition. The concept of Positive Energy Districts (PEDs) is one of the main initiatives in Europe for the clean energy transition in the built environment. While PEDs are mainly heading for the energy transition, little is known how they relate to the holistic concept of planetary boundaries (PB). To be able to build representative methodology for sustainability assessment of PEDs as well as define comparable, measurable, and reliable indicators specifically targeted for the district scale, we take a closer look at the concept of PB in order to analyze how this concept can help to establish a holistic sustainability evaluation of PEDs. Below we present an analysis of two PED concepts to discuss their interrelation with the PB concept. Our research is based on literature and document analysis. We identify the need for a comprehensive understanding of the different aspects impacting the sustainability assessment of PEDs. In this sense, although highly advisable, an integrated and systemic approach to the sustainability assessment of PEDs has still not been consolidated and the main environmental, economic, and social pillars are usually treated as separate spheres with limited interlinked issues.
Regional Metabolism: A Material and Product Flow Accounting Model for Trentino, Italy
Authors: Bastos Joana , Rosado Leonardo 
Published: December 2023

AbstractMaterial flow accounting (MFA) can be applied to systematically quantify material inputs, outputs and throughputs to and from a geographical area, providing particularly relevant insights into managing resource flows and stocks, and identifying opportunities to close material cycles, moving from a linear to a circular economy. Remarkable advances in recent years have been made on the application of MFA to regions and cities, in particular going beyond material to product flows and providing increased details on life-cycle stages of products across these flows, which are crucial to estimate, understand and manage their associated environmental impacts. This chapter presents an MFA model of the Autonomous Province of Trento (Trentino) in northern Italy, and of the province’s capital city Trento. The main purpose is to establish a model to estimate direct material inputs (DMI) and domestic material consumption (DMC) in thousand tonnes per year (reference year 2019), relying on publicly available online data on domestic resource extraction, industrial production, trade, freight transportation and waste generation. The DMC was 12.8 and 13.5 tonnes per capita in the province and in Trento, respectively; the result is below the EU mean of 14.2, but significantly higher than the reported DMC for Italy in the same year of 8.3 tonnes per capita. Accounting and characterizing resource flows associated with urban areas and regions is crucial to increase resource efficiency and mitigate environmental impacts at local, regional and global levels. Advanced detailed MFA models at city and regional levels can inform and support environmentally sustainable planning and policymaking.