bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sorting lung tumor volumes from 4D‐MRI data using an automatic tumor‐based signal reduces stitching artifacts
Authors: Warren Mark , Barrett Alexander , Bhalla Neeraj , Brada Michael , Chuter Robert , Cobben David , Eccles Cynthia L. , Hart Clare , Ibrahim Ehab , McClelland Jamie , Rea Marc , Turtle Louise , Fenwick John D. 
Published: January 2024

AbstractPurposeTo investigate whether a novel signal derived from tumor motion allows more precise sorting of 4D‐magnetic resonance (4D‐MR) image data than do signals based on normal anatomy, reducing levels of stitching artifacts within sorted lung tumor volumes.Methods(4D‐MRI) scans were collected for 10 lung cancer patients using a 2D T2‐weighted single‐shot turbo spin echo sequence, obtaining 25 repeat frames per image slice. For each slice, a tumor‐motion signal was generated using the first principal component of movement in the tumor neighborhood (TumorPC1). Signals were also generated from displacements of the diaphragm (DIA) and upper and lower chest wall (UCW/LCW) and from slice body area changes (BA). Pearson r coefficients of correlations between observed tumor movement and respiratory signals were determined. TumorPC1, DIA, and UCW signals were used to compile image stacks showing each patient's tumor volume in a respiratory phase. Unsorted image stacks were also built for comparison.For each image stack, the presence of stitching artifacts was assessed by measuring the roughness of the compiled tumor surface according to a roughness metric (Rg). Statistical differences in weighted means of Rg between any two signals were determined using an exact permutation test.ResultsThe TumorPC1 signal was most strongly correlated with superior‐inferior tumor motion, and had significantly higher Pearson r values (median 0.86) than those determined for correlations of UCW, LCW, and BA with superior‐inferior tumor motion (p < 0.05).Weighted means of ratios of Rg values in TumorPC1 image stacks to those in unsorted, UCW, and DIA stacks were 0.67, 0.69, and 0.71, all significantly favoring TumorPC1 (p = 0.02–0.05). For other pairs of signals, weighted mean ratios did not differ significantly from one.ConclusionTumor volumes were smoother in 3D image stacks compiled using the first principal component of tumor motion than in stacks compiled with signals based on normal anatomy.
Peripheral nervous system manifestations of MOG antibody associated disease
Authors: Gupta Pranjal , Paul Pritikanta , Redenbaugh Vyanka , Guo Yong , Lucchinetti Claudia , Abdulrahman Yahya , Datta Abhigyan , Shah Shailee , Klein Christopher J. , Pittock Sean J. , Flanagan Eoin P. , Dubey Divyanshu 
Published: January 2024

AbstractRecent studies have reported the involvement of peripheral nervous system (PNS) in association with MOG‐IgG, including isolated neuropathies. In this retrospective study we characterized the PNS involvement in MOG antibody associated disease (MOGAD). Six out of 215 MOGAD patients had PNS involvement (all polyradiculopathy) that occurred concurrently with a CNS demyelinating episode. We also demonstrated MOG expression in healthy human controls' proximal nerve root. Nine patients with true‐positive MOG‐IgG1 had PNS involvement temporally unrelated to a CNS demyelinating event. All these patients had an alternate etiology of PNS involvement. Isolated peripheral neuropathy is not a feature of MOGAD, but inflammatory nerve root involvement can occur concurrently with CNS demyelinating events.
Restrained Li|Garnet Interface Contact Deterioration Manipulated by Lithium Modification for Solid‐State Batteries
Authors: Zhu Fangjun , Hu Xinyu , Xu Laiqiang , Zhang Baichao , Wang Haoji , Ni Lianshan , Deng Weina , Deng Wentao , Zou Guoqiang , Hou Hongshuai , Ji Xiaobo 
Published: January 2024

AbstractGarnet solid state electrolytes (SSEs) have emerged as propitious candidates for solid‐state batteries (SSBs) with exceptional ionic conductivity and excellent (electro)chemical stability. However, the Li|garnet interface contact deterioration still remains a major challenge resulting in Li dendrite propagation. Herein, a method is proposed to strengthen the adhesion of garnet SSE and Li by incorporating Sr3N2 into the Li metal. Density functional theory (DFT) calculations reveal that the interfacial formation energy of Li|garnet is decreased by the obtained Li‐Sr‐N (LSN) composite, which can enable a shift from poor contact to intimate bonding at the Li|garnet interface and a homogenous Li+ flux as well as electric field distribution. Simultaneously, the produced Li3N and LiSrN, which are known for their strong Li adsorption affinity and rapid Li+ transfer kinetics, actively govern the Li plating process. Thereby this rational design brings a notable reduction in interfacial impedance (4.5 Ω cm2), along with the increased critical current density (1.3 mA cm−2) and enhanced cycle stability (1200 h at 0.3 mA cm−2). Furthermore, The LFP|garnet|LSN full cell has demonstrated remarkable cycling performance (95.9% capacity retention after 200 cycles at 1 C) and favorable rate capability (150.2 mAh g−1 at 0.1 C and 134.9 mAh g−1 at 1 C). The research provides a new sight into lithium modification that can restrain Li|garnet interface deterioration and lay the groundwork for future advancements in high‐performance garnet‐ based SSBs.
Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study
Authors: Soons Lion M. , Deckers Kay , Tange Huibert , van Boxtel Martin P. J. , Köhler Sebastian 
Published: January 2024

AbstractINTRODUCTIONHearing loss (HL) has been associated with cognitive decline and dementia. We examined the temporal association between prevalent and incident HL and cognitive change.METHODSA total of 1823 participants (24‐82 years) from the Maastricht Aging Study (MAAS) were assessed at baseline, 6 and 12 years, including pure‐tone audiometry. Linear‐mixed models were used to test the association between HL and cognition, adjusted for demographics and other dementia risk factors.RESULTSParticipants with prevalent and incident HL showed a faster decline in verbal memory, information processing speed, and executive function than participants without HL. Decline was steady from baseline to 6 and 12 years for prevalent HL, but time‐delayed from 6 to 12 years for incident HL. Having a hearing aid did not change associations.DISCUSSIONFindings support the notion that HL is a risk factor for cognitive decline independent of other dementia risk factors. Onset of HL preceded onset of cognitive decline.Highlights
We examined cognitive change in prevalent and incident hearing loss.
Prevalent and incident hearing loss were associated with faster cognitive decline.
For prevalent hearing loss, decline was steady from baseline to 6 and 12 years.
Onset of hearing loss preceded the onset of cognitive decline.
Having a hearing aid did not change the observed associations.
Cascade Electrocatalytic and Thermocatalytic Reduction of CO2 to Propionaldehyde
Authors: Zhang Jie , Kang Xingsi , Yan Yuchen , Ding Xue , He Lin , Li Yanguang 
Published: January 2024

AbstractElectrochemical CO2 reduction can convert CO2 to value‐added chemicals, but its selectivity toward C3+ products are very limited. One possible solution is to run the reactions in hybrid processes by coupling electrocatalysis with other catalytic routes. In this contribution, we report the cascade electrocatalytic and thermocatalytic reduction of CO2 to propionaldehyde. Using Cu(OH)2 nanowires as the precatalyst, CO2/H2O is reduced to concentrated C2H4, CO, and H2 gases in a zero‐gap membrane electrode assembly (MEA) reactor. The thermochemical hydroformylation reaction is separately investigated with a series of rhodium‐phosphine complexes. The best candidate is identified to be the one with the 1,4‐bis(diphenylphosphino)butane diphosphine ligand, which exhibits a propionaldehyde turnover number of 1148 under a mild temperature and close‐to‐atmospheric pressure. By coupling and optimizing the upstream CO2 electroreduction and downstream hydroformylation reaction, we achieve a propionaldehyde selectivity of ~38 % and a total C3 oxygenate selectivity of 44 % based on reduced CO2. These values represent a more than seven times improvement over the best prior electrochemical system alone or over two times improvement over other hybrid systems.
Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition
Authors: Möhler Jasper S. , Pickl Mathias , Reiter Tamara , Simić Stefan , Rackl Jonas W. , Kroutil Wolfgang , Wennemers Helma 
Published: January 2024

AbstractEnzymes and peptide catalysts consist of the same building blocks but require vastly different environments to operate best. Herein, we show that an enzyme and a peptide catalyst can work together in a single reaction vessel to catalyze a two‐step cascade reaction with high chemo‐ and stereoselectivity. Abundant linear alcohols, nitroolefins, an alcohol oxidase, and a tripeptide catalyst provided chiral γ‐nitroaldehydes in aqueous buffer. High yields (up to 92 %) and stereoselectivities (up to 98 % ee) were achieved for the cascade through the rational design of the peptide catalyst and the identification of common reaction conditions.
On‐Surface Isomerization of Indigo within 1D Coordination Polymers
Authors: Xu Hongxiang , Chakraborty Ritam , Adak Abhishek Kumar , Das Arpan , Yang Biao , Meier Dennis , Riss Alexander , Reichert Joachim , Narasimhan Shobhana , Barth Johannes V. , Papageorgiou Anthoula C. 
Published: January 2024

AbstractNatural products are attractive components to tailor environmentally friendly advanced new materials. We present surface‐confined metallosupramolecular engineering of coordination polymers using natural dyes as molecular building blocks: indigo and the related Tyrian purple. Both building blocks yield identical, well‐defined coordination polymers composed of (1 dehydroindigo : 1 Fe) repeat units on two different silver single crystal surfaces. These polymers are characterized atomically by submolecular resolution scanning tunnelling microscopy, bond‐resolving atomic force microscopy and X‐ray photoelectron spectroscopy. On Ag(100) and on Ag(111), the trans configuration of dehydroindigo results in N,O‐chelation in the polymer chains. On the more inert Ag(111) surface, the molecules additionally undergo thermally induced isomerization from the trans to the cis configuration and afford N,N‐ plus O,O‐chelation. Density functional theory calculations confirm that the coordination polymers of the cis‐isomers on Ag(111) and of the trans‐isomers on Ag(100) are energetically favoured. Our results demonstrate post‐synthetic linker isomerization in interfacial metal‐organic nanosystems.
Clinicopathological comparison between PTCL‐TBX21 and PTCL‐GATA3 in Japanese patients
Authors: Shimasaki Yasumasa , Miyoshi Hiroaki , Kawamoto Keisuke , Yoshida Noriaki , Mishina Tatsuzo , Nakashima Kazutaka , Imamoto Teppei , Sugio Takeshi , Yanagida Eriko , Kato Takeharu , Yamada Kyohei , Takeuchi Mai , Suzuki Takaharu , Moritsubo Mayuko , Furuta Takuya , Imaizumi Yoshitaka , Takizawa Jun , Kato Koji , Suzumiya Junji , Suzuki Ritsuro , Ohshima Koichi 
Published: January 2024

AbstractAimPeripheral T‐cell lymphoma not otherwise specified (PTCL‐NOS) is a heterogeneous disease that can be classified into the PTCL‐TBX21 and PTCL‐GATA3 subtypes.MethodsIn this study, we compared the clinicopathological features of PTCL‐NOS in a Japanese cohort, classified using an IHC algorithm.ResultsOne hundred patients with PTCL‐NOS were categorized as having PTCL‐TBX21 (n = 55), PTCL‐GATA3 (n = 24), or PTCL‐unclassified (n = 21). When comparing PTCL‐TBX21 and PTCL‐GATA3, PTCL‐TBX21 showed significantly lower CD4 positivity (p = 0.047), lower counts of high endothelial venules (p = 0.032), and a tendency for a better response to initial treatment (p = 0.088). Gene expression analysis using the nCounter system showed higher expression of tumor immunity‐related genes, such as PD‐L1, LAG3, and IDO1, in PTCL‐TBX21 than in PTCL‐GATA3. PTCL‐GATA3 had significantly worse overall survival (OS) than those with PTCL‐TBX21 (p = 0.047), although a similar tendency was observed for progression‐free survival (PFS) (p = 0.064). PTCL‐GATA3 was a prognostic factor for OS in univariate analysis (HR 2.02; 95% CI, 1.09–3.77; p = 0.027), although multivariate analysis did not show significance (HR 2.07; 95% CI, 0.93–4.61; p = 0.074). In the PFS analysis, PTCL‐GATA3 was an independent prognostic factor by univariate analysis (HR 1.96; 95% CI, 1.08–3.56; p = 0.027) and multivariate analysis (HR 2.34; 95% CI, 1.07–5.11; p = 0.032).ConclusionThe classification of PTCL‐NOS into PTCL‐TBX21 and PTCL‐GATA3 is useful for predicting the prognosis of Japanese patients and stratifying the administration of tumor immune checkpoint inhibitors in clinical practice.
Machine learning‐based model constructed from ultrasound radiomics and clinical features for predicting HER2 status in breast cancer patients with indeterminate (2+) immunohistochemical results
Authors: Yan Meiying , Yao Jincao , Zhang Xiao , Xu Dong , Yang Chen 
Published: January 2024

AbstractBackgroundWe aimed to predict human epidermal growth factor receptor 2 (HER2) 2+ status in patients with breast cancer by constructing and validating machine learning models utilizing ultrasound (US) radiomics and clinical features.MethodsWe analyzed 203 breast cancer cases immunohistochemically determined as HER2 2+ and used fluorescence in situ hybridization (FISH) as the confirmation method. From each case, the study analyzed 840 extracted radiomics features and 11 clinicopathologic features. Cases were randomly split into training (n = 141) and validation sets (n = 62) at a 7:3 ratio. Univariate logistic regression analysis was first performed on the 11 clinicopathologic characteristics. The least absolute shrinkage and selection operator (LASSO) and decision tree (DT) techniques were employed for post‐feature selection. Finally, 19 radiomics features were utilized in logistic regression (LR) and Naive Bayesian (NB) classifiers. Model performance was gauged using the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity.ResultsOur models exhibited notable diagnostic efficacy in differentiating HER2‐positive from negative breast cancer cases. In the validation sets, the LR model outperformed the NB model with an AUC of 0.860 and accuracy of 83.8% compared to NB's AUC of 0.684 and accuracy of 79.0%. The LR model demonstrated higher sensitivity (92.3% vs. 46.2%) while the NB model had a better specificity (91.8% vs. 63.3%) in the validation set.ConclusionsMachine learning models grounded on radiomics efficiently predicted IHC HER2 2+ status in breast cancer patients, suggesting potential enhancements in clinical decision‐making for treatment and management.
Eosin‐G and ethyl eosin dye sensitized CdS nanowires towards dye sensitized solar cells applications
Authors: Khodiyar Bhoomi , Mendhe Avinash C. , Deshmukh Tushar B. , Sankapal Babasaheb R. 
Published: January 2024

AbstractOne dimensional (1‐D) CdS nanowires have been grown through a low temperature chemical route and have been sensitized with eosin‐G and ethyl eosin dyes to broaden the absorption spectrum of CdS and to enhance the photoelectrochemical (PEC) performance under illumination. The used method is advantageous due to its simplicity, low cost, scalability, and controllability. Interestingly, eosin‐G and ethyl eosin dyes yield nearly four‐ and six‐fold increase in device efficiency compared to bare CdS when tested in dye‐sensitized solar cell assembly. Structural, surface morphological, optical, and surface wettability studies have been formulated for CdS, whereas identification of materials along with PEC investigations were conducted through current density–voltage (J‐V), external quantum efficiency (EQE), characteristics under the illumination of 94.6 mW/cm2 (AM 1.5G), and electrochemical impedance spectroscopy (EIS).
Facile Synthesis of Novel Ti2C Nano Bipyramids for Photothermal and Photodynamic Therapy of Breast Cancer
Authors: Ali Israt , Chang Li‐Mei , Farheen Jabeen , Huang Jiandong , Gu Zhi‐Gang 
Published: January 2024

AbstractPhoto‐responsive synergetic therapeutics achieved significant attraction in cancer theranostic due to the versatile characteristics of nanomaterials. There have been substantial efforts in developing the simplest nano‐design with exceptional synergistic properties and multifunctionalities. In this work, biocompatible Ti2C MXene nano bipyramids (MNBPs) were synthesized by hydrothermal method with dual functionalities of photothermal and photodynamic therapies. The MNBPs shape was obtained from two‐dimensional (2D) Ti2C nanosheets by controlling the temperature of the reaction mixture. The structure of these Ti2C MNBPs was characterized by a high‐resolution transmission electron microscope, scanning electron microscope, atomic force microscope, X‐ray photoelectron spectroscopy, and X‐ray diffraction. The Ti2C NBPs have shown exceptional photothermal properties with increased temperature to 72.3 °C under 808 nm laser irradiation. The designed nano bipyramids demonstrated excellent cellular uptake and biocompatibility. The Ti2C NBP has established a remarkable photothermal therapy (PTT) effect against 4T1 breast cancer cells. Moreover, Ti2C NBPs showed a profound response to UV light (6 mW/cm2) and produced reactive oxygen species, making them useful for photodynamic therapy (PDT). These in‐vitro studies pave a new path to tune the properties of photo‐responsive MXene nanosheets, indicating a potential use in biomedical applications.
Between commitment and reality: A critical examination of Jordan's adherence to the New York Convention 1958
Authors: Tarawneh Mosleh A. , Alhasan Tariq K. 
Published: January 2024

AbstractThis study critically evaluates Jordan's bifurcated approach to the enforcement of arbitral awards, with an emphasis on its domestic laws and international obligations under the New York Convention. Utilizing a rigorous methodology that melds doctrinal scrutiny with comparative legal analysis, the research delves into Jordan's Arbitration Law 31 of 2001, its subsequent amendments, and the Enforcement of Foreign Judgments Law 8 of 1952. The analysis reveals a marked incongruence between Jordan's national legal frameworks for recognizing and enforcing foreign arbitral awards and its commitments under Article 3 of the New York Convention. The study further quantifies the financial and procedural barriers erected by Jordan's stratified judicial system, contrasting them with universally accepted benchmarks. Informed by international jurisprudence, the research proffers targeted policy recommendations designed to harmonize Jordan's arbitration regulations with prevailing pro‐enforcement international standards. This investigation fills a scholarly void and offers pragmatic, timely solutions, thereby contributing to the global dialogue on compliance with international arbitration norms, particularly from a Jordanian vantage point.
Copeptin and the syndrome of inappropriate antidiuresis (SIAD) after pituitary transsphenoidal surgery
Authors: Efthymiadis Agathoklis , Pofi Riccardo , Rostom Hussam , James Tim , Shine Brian , Guha Nish , Cudlip Simon , Christ‐Crain Mirjam , Pal Aparna 
Published: January 2024

AbstractObjectiveThis study evaluates the predictive value of copeptin for syndrome of inappropriate antidiuresis (SIAD) postpituitary transsphenoidal surgery (TSS).DesignData from 133 consecutive patients undergoing TSS (November 2017–October 2022) at Oxford University Hospitals NHS trust are presented in this retrospective study.MethodsLogistic regression (LR) and receiver operating characteristic (ROC) curves were performed to evaluate the diagnostic utility of copeptin. The Mann–Whitney U test was used to compare copeptin levels between the SIAD and no SIAD groups.ResultsFourteen patients (10.8%) developed SIAD. Copeptin was available in 121, 53 and 87 patients for Days 1, 241 and 8 post‐TSS, respectively. LR for Day 1 copeptin to predict SIAD gave an odds ratio (OR) of 1.0 (95%CI 42 0.84–1.20, p = .99), area under‐ROC curve (AUC) was 0.49; Day 2 copeptin OR was 0.65 (95%CI 0.39–1.19, 43 p = .77), AUC was 0.57 LR for Day 1 sodium to predict SIAD gave an odds ratio (OR) of 1.0 (95%CI 0.85–1.21, p = .99), AUC was 0.50.ConclusionsIn conclusion, our data provide no evidence for copeptin as a predictive marker for post‐TSS SIAD.
Hyphal‐associated protein expression is crucial for Candida albicans‐induced eicosanoid biosynthesis in immune cells
Authors: Schimanski Jana , Gresnigt Mark S. , Brunner Elena , Werz Oliver , Hube Bernhard , Garscha Ulrike 
Published: January 2024

AbstractCandida albicans causes opportunistic infections ranging from mucosal mycoses to life‐threatening systemic infections in immunocompromised patients. During C. albicans infection, leukotrienes and prostaglandins are formed from arachidonic acid by 5‐lipoxygenase (5‐LOX) and cyclooxygenases, respectively to amplify inflammatory conditions, but also to initiate macrophage infiltration to achieve tissue homeostasis. Since less is known about the cellular mechanisms triggering such lipid mediator biosynthesis, we investigated the eicosanoid formation in monocyte‐derived M1 and M2 macrophages, neutrophils and HEK293 cells transfected with 5‐LOX and 5‐LOX‐activating protein (FLAP) in response to C. albicans yeast or hyphae. Leukotriene biosynthesis was exclusively induced by hyphae in neutrophils and macrophages, whereas prostaglandin E2 was also formed in response to yeast cells by M1 macrophages. Eicosanoid biosynthesis was significantly higher in M1 compared to M2 macrophages. In HEK_5‐LOX/FLAP cells only hyphae activated the essential 5‐LOX translocation to the nuclear membrane. Using yeast‐locked C. albicans mutants, we demonstrated that hyphal‐associated protein expression is critical in eicosanoid formation. For neutrophils and HEK_5‐LOX/FLAP cells, hyphal wall protein 1 was identified as the essential surface protein that stimulates leukotriene biosynthesis. In summary, our data suggest that hyphal‐associated proteins of C. albicans are central triggers of eicosanoid biosynthesis in human phagocytes.
Stimuli‐responsive linkers and their application in molecular imaging
Authors: Wang Jing , Liu Meng , Zhang Xinyue , Wang Xinning , Xiong Menghua , Luo Dong 
Published: January 2024

AbstractMolecular imaging is a non‐invasive imaging method that is widely used for visualization and detection of biological events at cellular or molecular levels. Stimuli‐responsive linkers that can be selectively cleaved by specific biomarkers at desired sites to release or activate imaging agents are appealing tools to improve the specificity, sensitivity, and efficacy of molecular imaging. This review summarizes the recent advances of stimuli‐responsive linkers and their application in molecular imaging, highlighting the potential of these linkers in the design of activatable molecular imaging probes. It is hoped that this review could inspire more research interests in the development of responsive linkers and associated imaging applications.