bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEKL-4 regulates microtubule stability and mitochondrial health inC. elegansciliated neurons
Authors: Power Kaiden M. , Nguyen Ken C. , Silva Andriele , Singh Shaneen , Hall David H. , Rongo Christopher , Barr Maureen M. 
Published: February 2024

AbstractCiliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-onset neurodegeneration. InC. elegans, ccpp-1loss causes age-related ciliary degradation that is suppressed by mutation in the conserved NEK10 homolognekl-4. NEKL-4 is absent from cilia, yet negatively regulates ciliary stability via an unknown, glutamylation-independent mechanism. We show that NEKL-4 was mitochondria-associated.nekl-4mutants had longer mitochondria, a higher baseline mitochondrial oxidation state, and suppressedccpp-1mutant lifespan extension in response to oxidative stress. A kinase-deadnekl-4(KD)mutant ectopically localized toccpp-1cilia and rescued degenerating microtubule doublet B-tubules. A nondegradablenekl-4(PESTΔ)mutant resembled theccpp-1mutant with dye filling defects and B-tubule breaks. Thenekl-4(PESTΔ)Dyf phenotype was suppressed by mutation in the depolymerizing kinesin-8 KLP-13/KIF19A. We conclude that NEKL-4 influences ciliary stability by activating ciliary kinesins and promoting mitochondrial homeostasis.SummaryNeurodegeneration and ciliary degeneration are caused by mutation of the deglutamylase CCP1/CCPP-1 in humans andC. elegans. The conserved NIMA-related kinase NEKL-4/NEK10 can suppress or promote degeneration in an activity-dependent manner that involves cilia-mitochondria communication and that is independent of glutamylation.
Using Cryogenic CMOS Control Electronics to Enable a Two-Qubit Cross-Resonance Gate
Authors: Underwood Devin , Glick Joseph A. , Inoue Ken , Frank David J. , Timmerwilke John , Pritchett Emily , Chakraborty Sudipto , Tien Kevin , Yeck Mark , Bulzacchelli John F. , Baks Chris , Robertazzi Raphael , Beck Matthew , Joshi Rajiv V. , Wisnieff Dorothy , Lekuch Scott , Gaucher Brian P. , Friedman Daniel J. , Rosno Pat , Ramirez Daniel , Ruedinger Jeff 
Published: February 2024

Qubit control electronics composed of CMOS circuits are of critical interest for next-generation quantum computing systems. A CMOS-based application-specific integrated circuit (ASIC) fabricated in 14-nm fin field-effect transistor (FinFET) technology was used to generate and sequence qubit control wave forms and demonstrate a two-qubit cross-resonance gate between fixed-frequency transmons. The controller was thermally anchored to the T=4 K stage of a dilution refrigerator and the measured power was 23 mW per qubit under active control. The chip generated single-side banded output frequencies between 4.5 and 5.5 GHz, with a maximum power output of −18 dBm. Randomized-benchmarking (RB) experiments revealed an average number of 1.71 instructions per Clifford (IPC) for single-qubit gates and 17.51 IPC for two-qubit gates. A single-qubit error per gate of ϵ1Q=8×10−4 and a two-qubit error per gate of ϵ2Q=1.4×10−2 were shown. A drive-induced Z rotation was observed by way of a rotary-echo experiment; this observation is consistent with the expected qubit behavior given the measured excess local-oscillator (LO) leakage from the CMOS chip. The effect of spurious drive-induced Z errors was numerically evaluated with a two-qubit model Hamiltonian and shown to be in good agreement with the measured RB data. The modeling results suggest that the Z error varies linearly with the pulse amplitude.

Published by the American Physical Society
2024
New developments in Macao's gaming public policy: implications and effectiveness
Authors: Wang Changbin 
Published: February 2024

PurposeThis paper examines the changes in Macao's gaming public policy following the 2022 revision of the gaming law. The revision introduces more regulations on the gaming industry and highlights the gaming industry's contribution to economic diversification, anti-money laundering and national security. The paper analyzes the economic, cultural and political factors that motivated these changes and evaluates the effectiveness of the new gaming public policy.Design/methodology/approachThis paper compares the different versions of Macao's gaming laws and the gaming laws of Nevada and New Jersey, using a qualitative approach to interpret the meanings behind the law text.FindingsThe paper reveals that Macao's gaming public policy has changed significantly. The revised policy focuses more on economic diversification than the growth of the gaming industry and imposes more responsibilities on the gaming operators. It predicts that Macao's gaming industry will face more difficulties in increasing its market share in the next decade.Practical implicationsThe findings of this paper can help the Macao government assess its gaming public policy and other governments learn from the complex situation when developing their public policies.Social implicationsThe findings of this paper can enhance the understanding of Macao's gaming laws and the reality of Macao's gaming industry.Originality/valueThis paper is the first in academia to address Macao's new public policy toward gaming.
The reaction of the Egyptian stock market to recurring devaluations: an event study approach
Authors: Elroukh Ahmed Wassal 
Published: February 2024

PurposeThis paper examines the reaction of the Egyptian stock market to two substantial devaluations of the Egyptian pound (EGP) in 2022 and tests the informational efficiency of the Egyptian market.Design/methodology/approachThe paper uses the event study framework to analyze the significance and direction of abnormal returns of the leading index of the Egyptian stock market (EGX30) on and around the devaluation days. It employs both the constant mean model and the market model to estimate the normal returns of the EGX30. Additionally, the paper uses data on two equity indices, one global and one for emerging markets, as benchmarks for normal returns.FindingsThe paper finds that the Egyptian stock market experienced significant positive abnormal returns on the devaluation days of the EGP in March and October of 2022, indicating a positive market reaction to the devaluation. Furthermore, evidence suggests that the Egyptian market may not be informationally efficient as significant positive abnormal returns were observed two weeks before and two weeks after the devaluation day, suggesting news leaks and delayed reactions, respectively.Originality/valueThis study is the first to examine the impact of the recent two devaluations of the EGP in 2022 on the Egyptian stock market. It complements existing literature by analyzing the immediate market reaction to two consecutive devaluations in an African country. Furthermore, the paper evaluates the efficiency of the Egyptian market in processing information related to exchange rates.
Regional income inequality in Brazil: state-level Distributional National Accounts
Authors: Bhering Davi 
Published: February 2024

PurposeBrazil’s regional inequality is an important topic due to the large and persistent differences in development between states and the high levels of inequality in the country. These variations in development can potentially render survey data inaccurate since the significance of capital income varies across the states. Besides, previous studies incorporating tax and national accounts data globally have mainly focused on measuring the income distribution at the country-level. This approach can limit the understanding of inequality, especially when considering large countries such as Brazil.Design/methodology/approachThe methodology used to construct these estimates follows the guidelines of the Distributional National Accounts, whose core goal is to provide income distribution measures consistent with macroeconomic aggregates and harmonized across countries and time. The procedure has three main steps: first, it corrects the survey’s underrepresentation of top incomes using tax data. Then, it accounts for national income items not included in the survey or tax data, such as imputed rents and undistributed profits. Finally, it ensures that all components match the national income.FindingsCompared to survey-based estimations, the results reveal a new angle on the state-level inequality. This study indicates that Amazonas, Rio de Janeiro and São Paulo have a more concentrated income distribution. The top 1\% of earners in these states receives around 28\% of total pre-tax income, while the top 10\% receive nearly 60\%. On the other end, Amapá (AP), Acre (AC), Rondônia (RO) and Santa Catarina (SC) are the states where the income distribution is less concentrated. There were no significant changes in the income distribution across the states during the period analyzed.Originality/valueThis study combines survey, tax and national accounts data to construct new estimates of Brazil’s state-level income distribution from 2006 to 2019. Previous results only considered income captured in surveys, which usually misses a significant part of capital incomes. This limitation may bias comparisons as capital income has different importance across the states. The new estimates represent the income of top groups more accurately, account for the entire national income and enable to compare regional inequality levels consistently with other countries.
GCC workforce nationalization: what factors contribute to the comprehensive implementation of Qatarization practices?
Authors: Elbanna Said 
Published: February 2024

PurposeMost prior literature on the GCC workforce nationalization has focused on a limited set of themes (e.g. nationalization challenges), initiatives (e.g. quota system) and methodology (e.g. qualitative) and none has captured the full range of content associated with its implementation phenomenon resulting in our current incomplete knowledge on it. As one of the first studies on this phenomenon, our study explores the factors influencing comprehensive implementation of workforce nationalization in Qatar. We postulate a research model based on the strategic human resource and strategic management works of literature which contain five exogenous variables under three perspectives: Qatarization, organizational and environmental.Design/methodology/approachThe study model was tested by using structural equation modeling (SEM) to analyze data collected from 300 managers in Qatar.FindingsThe results show that four variables –formal Qatarization planning, top management commitment, Qatarization experience and stakeholder pressures – positively influence the comprehensive implementation of Qatarization efforts.Practical implicationsSuccessfully implementing Qatarization objectives requires a robust synergy between dedicated planning and unwavering commitment from top management. Further, to effectively navigate the challenges of nationalization, collaboration with key stakeholders becomes pivotal. Our findings offer actionable insights for public organizations aiming to optimize their Qatarization efforts, emphasizing the integral role of holistic strategies and committed leadership.Originality/valueWe introduce a novel research model rooted in both strategic human resource and strategic management theories. Diverging from traditional qualitative approaches, our quantitative methodology provides empirical depth to our findings.
Bridging the valley of death: examining university science parks' influence on revenue generation
Authors: Qi Xin-Zhou , Li Eric Ping Hung , Wei Zhuangyu , Ning Zhong 
Published: February 2024

PurposeThis study examines the impact of university science parks’ (USPs) capabilities on revenue generation and introduces regional innovation as a moderating variable. This study aims to provide insights into enhancing revenue generation and fully leveraging the role of USPs in promoting revenue generation.Design/methodology/approachThis study employs system generalized method of moments (GMM) estimation for 116 universities in China from 2008 to 2020, using hierarchical regression analysis to examine the relationships between variables.FindingsThe findings suggest that USPs play a beneficial role in fostering revenue generation. Specifically, the provision of incubation funding demonstrates a positive correlation, while USPs size exhibits an inverted U-shaped pattern, with a threshold at 3.037 and a mean value of 3.712, highlighting the prevalent issue of suboptimal personnel allocation in the majority of USPs. Moreover, the analysis underscores the critical moderating influence of regional innovation, affecting the intricate interplay between USPs size, incubation funding and revenue generation.Research limitations/implicationsThe single country (China) analysis relied solely on the use of secondary data. Future studies could expand the scope to include other countries and employ primary data collection. For instance, future research can further examine how regional development and USPs strategic plan impact revenue generation.Practical implicationsThe study recommends that USPs managers and policymakers recognize the importance of incubation funding and determine the optimal quantity of USPs size to effectively foster revenue generation in USPs. Policymakers can use regional innovation as a moderating variable to reinforce the relationship between USPs size and incubation funding on revenue generation.Social implicationsThe study’s findings can contribute to the strategic industry growth and economic development of nations by promoting revenue generation. Leveraging the role of USPs and implementing the study’s recommendations can strengthen innovation and technology capabilities, driving strategic industry growth and economic development. This can enhance global competitiveness and promote sustainable economic growth.Originality/valueThis study introduces regional innovation as a moderating variable and provides empirical evidence of its influence on the relationship between USPs size and incubation funding on revenue generation. This adds value to research to the existing literature on USPs and revenue generation by showcasing the importance of examining the regional impact in research and innovation.
The use of tracker technologies on branded prescription drug websites: privacy, data acquisition and programmatic advertising
Authors: Alperstein Neil 
Published: February 2024

Purpose
The purpose of this study was to examine consumer data acquired by branded prescription drug websites and the ethics of privacy related to the interconnected web of personal information accessed, packaged and resold by tracker technologies.

Design/methodology/approach
The research used the DMI Tracker Tool to collect data on the top 17 branded prescription drug websites, with a specific interest in the tracker technologies embedded in those websites. That data was analyzed using Gephi, an open-source data visualization tool, to map the network of trackers embedded in those branded prescription drug websites.

Findings
Findings visualize the interconnections between tracker technologies and prescription drug websites that undergird a system of personal data acquisition and programmatic advertising vehicles that serve the interests of prescription drug marketers and Big Tech. Based on the theory of platform ethics, the study demonstrated the presence of a technostructural ecosystem dominated by Big Tech, a system that goes unseen by consumers and serves the interests of advertisers and resellers of consumer data.

Research limitations/implications
The 17 websites used in this study were limited to the top-selling prescription drugs or those with the highest ad expenditures. As such this study is not based on a random sampling of branded prescription drug websites. The popularity of these prescription drugs or the expanse of advertising associated with the drugs makes them appropriate to study the presence of tracking devices that collect data from consumers and serve advertising to them. It is also noted that websites are dynamic spaces, and some trackers within their infrastructures are apt to change over time.

Practical implications
Branded prescription drug information has over the past three decades become part of consumers’ routine search for information regarding what ails them. As drug promotion moved from print to TV and the Web, searching for drug information has become a part of everyday life. The implications of embedded trackers on branded prescription drug websites are the subject of this research.

Social implications
This study has significant social implications as consumers who are searching for information regarding prescription medications may not want drug companies tracking them in a way that many perceive to be an invasion of privacy. Yet, as the Web is dominated by Big Tech, web developers have little choice but to remain a part of this technostructural ecosystem.

Originality/value
This study sheds light on branded prescription drug websites, exploring the imbalance between the websites under study, Big Tech and consumers who lack awareness of the system that operates backstage.
Mitigating postreplanting risks of oil palm plantations: seed institutional perspective
Authors: Ardana I Ketut , Wulandari Suci , Hartati Rr Sri , Hasibuan Abdul Muis 
Published: February 2024

PurposeThis study assesses postreplanting oil palm farming risks, analyzes seed procurement parameters, investigates seed institutions' performance factors and develops a framework for improved sustainability.Design/methodology/approachIncorporating data from 219 smallholder farmers in designated replanting areas, our study comprehensively evaluates seed supply performance, examining the roles of stakeholders and identifying potential risks in seed management. We assess these risks using the Risk Priority Number (RPN) methodology and Multidimensional Scaling (MDS) techniques.FindingsThe results show that the timing and quantity of oil palm seed supply have a relatively small impact on postreplanting failure risk. To mitigate this risk, focus on monitoring seed purity using high-quality Tenera oil palm-type seeds and early detection technology. Encourage seed-producing cooperatives to become legal seed producers for an inclusive system and consider smallholders' variety preferences.Originality/valueThis study’s significance lies in its comprehensive assessment of the risks associated with oil palm replanting on smallholder plantations, detailed analysis of critical parameters in seed procurement, investigation into the performance of palm oil seed institutions across various dimensions and development of a strategic framework to strengthen inclusive seed institutions for sustainable oil palm farming. This strategy holds valuable potential for the development of oil palm in Indonesia, particularly in expediting the smallholders' replanting program.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-10-2023-0811
Fuzzy logic system-based force tracking control of robot in highly dynamic environments
Authors: Liu Chengguo , Li Junyang , Li Zeyu , Chen Xiutao 
Published: February 2024

Purpose
The study aims to equip robots with the ability to precisely maintain interaction forces, which is crucial for tasks such as polishing in highly dynamic environments with unknown and varying stiffness and geometry, including those found in airplane wings or thin, soft materials. The purpose of this study is to develop a novel adaptive force-tracking admittance control scheme aimed at achieving a faster response rate with higher tracking accuracy for robot force control.

Design/methodology/approach
In the proposed method, the traditional admittance model is improved by introducing a pre-proportional-derivative controller to accelerate parameter convergence. Subsequently, the authors design an adaptive law based on fuzzy logic systems (FLS) to compensate for uncertainties in the unknown environment. Stability conditions are established for the proposed method through Lyapunov analysis, which ensures the force tracking accuracy and the stability of the coupled system consisting of the robot and the interaction environment. Furthermore, the effectiveness and robustness of the proposed control algorithm are demonstrated by simulation and experiment.

Findings
A variety of unstructured simulations and experimental scenarios are designed to validate the effectiveness of the proposed algorithm in force control. The outcomes demonstrate that this control strategy excels in providing fast response, precise tracking accuracy and robust performance.

Practical implications
In real-world applications spanning industrial, service and medical fields where accurate force control by robots is essential, the proposed method stands out as both practical and straightforward, delivering consistently satisfactory performance across various scenarios.

Originality/value
This research introduces a novel adaptive force-tracking admittance controller based on FLS and validated through both simulations and experiments. The proposed controller demonstrates exceptional performance in force control within environments characterized by unknown and varying.
Children and adolescents as perpetrators of stalking: an overview
Authors: Barr Ethan , Newman Andrew 
Published: February 2024

Purpose
Stalking is considered a public health priority with a range of adverse outcomes. This paper aims to explore existing literature on children and adolescents as perpetrators of stalking, with a focus on rates of stalking and victim and perpetrator characteristics associated with stalking.

Design/methodology/approach
A review of research where stalking was engaged in by those 18 years old and younger was conducted, where 17 manuscripts met criteria for review.

Findings
This review found a prevalence of young people engaging in stalking of between 5.3% and 36%. Considerations including demographics, typologies, prior relationship characteristics, stalking and pursuit tactics, cyberstalking and a brief consideration of the impact are given.

Practical implications
Literature considering perpetration remains thin, and future research should seek to move towards a widely acceptable definition of stalking, as well as considering effective interventions for early intervention, and to consider the role of mental health services in supporting perpetrators and victims, who may not always be mutually exclusive groups.

Originality/value
This paper extends previous literature reviews; the authors understand this to be original work that contributes to a gap in the literature.