bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Sympathetic Responses to Lower Body Negative Pressure
Authors: Jarrard Caitlin P. , Watso Joseph C. , Atkins Whitley C. , McKenna Zachary J. , Foster Josh , Huang Mu , Belval Luke N. , Crandall Craig G. 
Published: January 2024

ABSTRACT

Introduction
Trauma-induced hemorrhage is a leading cause of death in prehospital settings. Experimental data demonstrate that females have a lower tolerance to simulated hemorrhage (i.e., central hypovolemia). However, the mechanism(s) underpinning these responses are unknown. Therefore, this study aimed to compare autonomic cardiovascular responses during central hypovolemia between the sexes. We hypothesized that females would have a lower tolerance and smaller increase in muscle sympathetic nerve activity (MSNA) to simulated hemorrhage.

Methods
Data from 17 females and 19 males, aged 19-45, were retrospectively analyzed. Participants completed a progressive lower-body negative pressure (LBNP) protocol to presyncope to simulate hemorrhagic tolerance with continuous measures of MSNA and beat-to-beat hemodynamic variables. We compared responses at baseline, at two LBNP stages (40 mmHg and 50 mmHg), and at immediately before presyncope. In addition, we compared responses at relative percentages (33%, 66%, and 100%) of hemorrhagic tolerance, calculated via the cumulative stress index (i.e., the sum of the product of time and pressure at each LBNP stage).

Results
Females had lower tolerance to central hypovolemia (female: 561 ± 309 vs. male: 894 ± 304 min*mmHg [time*LBNP]; p = 0.003). At LBNP 40 mmHg and 50 mmHg, females had lower diastolic blood pressures (main effect of sex: p = 0.010). For the relative LBNP analysis, females exhibited lower MSNA burst frequency (main effect of sex: p = 0.016) accompanied by a lower total vascular conductance (sex: p = 0.028; main effect of sex).

Conclusions
Females have a lower tolerance to central hypovolemia, which was accompanied by lower diastolic blood pressure at 40 and 50 mmHg LBNP. Notably, females had attenuated MSNA responses when assessed as relative LBNP tolerance time.
Der Aufstieg der Landsmannschaft aus Elsass-Burgund im preußischen Zweig des Deutschen Ordens im späten 14. Jahrhundert
Authors: Gotowko Piotr 
Published: January 2024

The rise of the brethren from Alsace-Burgundy in the Prussian branch of the Teutonic Order in the late 14th century

In the late fourteenth century, brethren of the Teutonic Order from Alsace-Burgundy, who had not played any role in the Prussian branch of the Teutonic Orden so far, gained much importance. At the end of 1379, not a single brother from that region had an important administrative function. Eighteen years, however, later they controlled two of six seats of the highest dignitaries, and two offices in the Komtur’s rank and two in the Pfleger’s rank. Key to such a success was – beside personal and professional connections – cooperation with the two Frankish Grand Masters, with the brethren from Swabia and also with one brother from probably Lower Austria. From the very beginning, the most important figures from Alsace-Burgundy were Johann Marschalk von Frohburg, then especially Werner von Tettingen, Konrad von Kyburg and Rudolf von Kyburg.
Exposición a sílice de mineros en altitud. Dosis inhalada, método de evaluación en condición de hipobaria
Authors: Zamora Saá Margarita , Jara-Jegó Rodolfo 
Published: January 2024

Objetivo: Evaluar la exposición a sílice de mineros chilenos en altitud usando diferentes metodologías, con el propósito de determinar el método más seguro para controlar la exposición.
Métodos: Los 46 mineros que conforman la muestra trabajan a 3000 metros sobre el nivel del mar con sistema de turnos no convencionales, en jornadas de 12 horas diarias por 4 días consecutivos, después de los cuales se descansa por otros 4 días. Se tomaron muestras de sílice en cada uno de los puestos de trabajo de estos 46 mineros en altitud. Los resultados de las concentraciones se presentan en (mg/m3). La exposición se evaluó usando el Threshold Limit Value y otras dos metodologías que incorporan parámetros respiratorios. Se determinó el grupo de mineros en riesgo con cada uno de estos métodos y se comparó la proporción de mineros expuestos en cada caso.
Resultados: evaluando con el Threshold Limit Value (método 1) se obtuvo un 43,48% de mineros en riesgo. Con los métodos que incluyen parámetros respiratorios se obtuvo una proporción de mineros sobre-expuestos del 82,61% con el método 2, y 73,91% con el método 3.
Conclusiones: de los tres métodos analizados, el que considera el parámetro respiratorio volumen minuto, a través de la estimación de la dosis inhalada, es el más seguro para definir el grupo de mineros en riesgo por exposición a sílice a gran altura.
The Dental Implications of Gastro-oesophageal Reflux Disease in Children
Authors: Gilani Maleeha , Anthonappa Robert 
Published: January 2024

Gastro-oesophageal reflux disease (GORD) is common in children and has numerous extra-oesophageal manifestations which dental practitioners should be aware of. This article illustrates the role of the dentist in recognizing the signs and symptoms of GORD in children. A risk-based management system is illustrated to guide clinicians in managing children exhibiting erosive tooth wear. CPD/Clinical Relevance: Dental implications of GORD in children and its management provide useful clinical information for dental practitioners.
Management of Severe Mental Illness in the Dental Setting: A Grey Matter?
Authors: Dusara Karishma , Cousins Hannah 
Published: January 2024

Dental professionals treat patients with a range of mental illnesses. This article focuses on severe mental illness (SMI) and highlights the challenges that people with a severe mental illness may experience when accessing dental care. Additionally, it looks at the oral implications of SMI and the management strategies that dental professionals can employ to support patients in the dental setting. This article will not cover all mental illnesses and readers can also consult the recent series on mental health covered by Dental Update. CPD/Clinical Relevance: Severe mental illness is a condition that may frequently present in patients treated in primary dental care. Therefore, it is essential dental professionals have an understanding of how this can affect dental care.
Penetrating Mid-facial Injury from a Wooden Branch
Authors: Williams Christina , Allison Nicola , Mustafa Shakir F 
Published: January 2024

This case report discusses the management of a patient with severe penetrating wooden branch wounds to the left mid-face following a fall in the garden. Penetrating trauma is classified as an injury that is caused by a foreign object piercing the skin, causing damage to the underlying tissues resulting in an open wound. Penetrating injuries to the head and neck often require attendance to an emergency care unit and subsequent treatment. There are numerous vital structures that can be affected and an understanding of the complex anatomy is vital to the safe management of these patients. CPD/Clinical Relevance: Treatment of facial trauma demands comprehensive understanding of the vital structures of the head/neck along with efficacious treatment delivery.
Dental Grillz
Authors: Shegar Sugan , Wilson Nairn HF 
Published: January 2024

Dental grillz, which come in many forms, have gained global popularity. This article explores their origins, online purchasing process and potential risks. A case study highlights limitations in remote provision and ill-fitting grillz. Risks include periodontal disease, caries and occlusal derangement. Dentists can play a role in minimizing these risks. The article emphasizes the need for increased awareness among dental professionals and parents regarding the potential drawbacks of grillz, particularly among teenagers. CPD/Clinical Relevance: The popularity of dental grillz is rising, hence clinicians need guidance and an awareness of the associated risks
Safety of perioperative treatment with biologics in patients with inflammatory bowel disease undergoing bowel surgery: Experience from a large urban center
Authors: Schnitzler Fabian , Tillack-Schreiber Cornelia , Szokodi Daniel , Braun Isabel , Tomelden June , Sohn Maximilian , Bader Franz , Waggershauser Constanze , Ochsenkühn Thomas 
Published: January 2024

Background and aims
Risks of peri- and postoperative complications after bowel surgery in patients with inflammatory bowel disease (IBD) receiving biologics are still discussed controversially. We therefore addressed the safety of different biologics that were applied in our IBD center before surgery.

Methods
Data of IBD patients who underwent bowel resections between 2012 and 2022 at our hospital were analyzed retrospectively. Exposure to biologics was defined by receiving biologics within 12 weeks before resective abdominal surgery. Safety considerations included minor complications, such as infections and wound healing disorders and major complications, e.g., anastomotic insufficiency or abscess formation.

Results
A total of 447 IBD patients (334 with Crohn’s disease, 113 with ulcerative colitis), 51.9% female, were included and followed for a median follow-up of 45 months [range 0–113]. A total of 73.9% (326/447) were undergoing medical treatment at date of surgery, 61.5% (275/447) were treated with biologics within 3 months and 42.3% (189/447) within 4 weeks before surgery. Most surgeries (97.1%) were planned electively and 67.8% were performed laparoscopically. Major and minor complications occurred in 20.8% (93/447) of patients. Serious complications were rare: Six patients had acute postoperative bleeding, one CD patient developed peritonitis and two CD patients died postoperatively. After adjusting for age, disease duration, disease activity, Montreal classification, and medical treatment at date of surgery, no significant differences were observed regarding complications and exposure to biologics.

Conclusions
This retrospective single center study of 447 IBD patients goes to demonstrate that perioperative use of biologics is not associated with a higher risk of complications.
Delayed Ustekinumab and Adalimumab Responders Have Similar Outcomes as Early Responders in Biologic-Naïve Crohn's Disease
Authors: Narula Neeraj , Wong Emily C.L. , Dulai Parambir S. , Marshall John K. , Jairath Vipul , Reinisch Walter 
Published: January 2024

INTRODUCTION:
Differences in 1-year outcomes among early and delayed responders have been demonstrated with some therapies in ulcerative colitis. However, it is unclear whether similar differences exist in patients with Crohn's disease (CD) treated with biologic therapies.

METHODS:
This was a post hoc analysis of patient-level data from the SEAVUE clinical trial program. Ustekinumab-treated and adalimumab-treated patients with clinical response at week 8, defined as a reduction in Crohn's Disease Activity Index (CDAI) score of at least 100 points from baseline or CDAI score <150, were deemed early responders and their outcomes were compared with delayed responders (week 8 nonresponders who subsequently responded at week 16) and nonresponders (no response at week 8 or 16). The primary outcome assessed was clinical remission at week 56, defined as CDAI <150.

RESULTS:
A total of 373 participants (187 treated with ustekinumab and 186 treated with adalimumab) were included in this analysis. The overall rate of delayed clinical response was low in the SEAVUE clinical trial program (13.1%). No differences were observed for week 56 clinical remission among early vs delayed responders to ustekinumab or adalimumab nor were there significant differences for secondary outcomes assessed. Delayed responders to ustekinumab and adalimumab had a significant decline in C-reactive protein by week 8 when compared with nonresponders.

DISCUSSION:
Among patients with moderate-to-severe CD, early and delayed responders to adalimumab and ustekinumab have similar 1-year clinical outcomes. Biomarker decline can be observed through the initial 8 weeks of therapy in patients who will eventually be delayed responders, which may help differentiate from nonresponders.
Solution Focused Brief Therapy Training
Authors: ARSLAN Ümüt , ULUS İhsan Çağatay 
Published: January 2024

Solution
Focused Brief Therapy (SFBT) is a therapy model that has been practiced since
the 1980s. Unlike traditional therapy models, it focuses on solutions instead
of problems. The basis of the application of SFBT is the solution-focused
questions that have been developed for many years by the method of tacit
presence. With the growing interest in SFBT in recent years, specific trainings
in this area have begun to be provided. Though there are SFBT Association
standards regarding the content of SFBT training, it usually takes two days
training in Turkey. In this study, it is
aimed to evaluate the SFBT training by investing view of counselors and
counselor candidates, who participated in a SFBT training. To do this, 76
participants were asked about the educational evaluation of the Northwest Brief
Therapy Training Center via the Google
form, and 50 people completed to answer these questions. This study is
researched by the qualitative research design, and it is preferred to collect
data by open-ended questionnaire using case study method. Results are displayed
on Google form and coded in response
to given responses. In conclusion, for most participants, practicing in
counseling under supervision is the reason to attend the training, counseling
practice activities that they are most satisfied with, and they thought more
counseling practice activities could be in training. It has been observed that
the SFBT training has had a positive impact on some of the participants'
professional and personal opinions about themselves and encourages participants
to improve themselves in their fields. Lastly, participants stated that they
would like to have a longer duration of SFBT training.
Content Analysis of Research on Processes of Constructing Knowledge in Mathematics Education in Turkey
Authors: TOPUZ Faden , CANTÜRK GÜNHAN Berna 
Published: January 2024

APOS, RBC, procept and abstraction theory with the students' knowledge creation processes on researches, are examined in order to scan in National Thesis Center, ULAKBİM, Google Scholar and papers in the symposium. A total of 27 postgraduate thesis, 15 articles and 8 papers were included in the study. By using descriptive content analysis method; the research was conducted by taking into consideration the year-type-publication language, sample-number and sampling type, the preferred topic and information creation theory in the research, the model-pattern and validityreliability used, data collection tools and data analysis methods. It was determined that the most studies were conducted in 2018, and in the field of algebra learning with numbers. Most of the studies were conducted at middle school level. Studies were conducted with a small number of students in terms of sample numbers. In most of the researches, qualitative models were preferred and mostly open-ended questions, achievement tests, video and audio recordings as well as data diversity were used for data collection. There were some deficiencies in the researches about the validation and reliability of the studies with sampling methods. In order to overcome these deficiencies, research methods courses given to the researches can be made more effective.
Keeping Online Diaries as an Integrated Activity for Writing Skill in EFL Classes: The Case of Penzu
Authors: YÜCE Erkan 
Published: January 2024

Web 2.0 tools can provide digital tools for teaching and learning for professionals who follow and apply the internet-based developments in their education contexts to enrich their conventional way of teaching. The present study focused on one of the Web 2.0 tools, Penzu. Penzu is a kind of online diary through which users can easily take notes and keep them on the Web. The study discussed the applicability of Penzu in foreign language classes as an integrated tool to develop language learners’ writing skills. In this respect, a sample Penzu page was prepared and introduced to foreign language teaching instructors at a state university in Turkey. The study followed a qualitative inquiry. Face-to-face interviews were conducted with the participants, and the data were collected through semi-structured interview questions. After analyzing the data, the results were reported descriptively. The results primarily indicated that the EFL instructors were in favor of implementing Penzu as an integrated tool in foreign language teaching classes to enhance students’ writing skills. The study also reported several strengths and weaknesses which may promote or hinder the implementation of Penzu language education contexts. All in all, this study attempted to alternate traditional foreign language teaching classes by implementation of Penzu as an integrated tool for writing skill, and to pave ways for further studies that foster application of Web 2.0 tools in language education contexts.
Dry Heat Treatment and Galangal Rhizome Extract on Soybean Seeds Infected with Xanthomonas axonopodis
Authors: Fauziyah Qonitah , Ramdan Evan Purnama , Risnawati Risnawati , Yulianti Fitri 
Published: January 2024

Kedelai (Glycine max) adalah salah satu sumber protein nabati yang kebutuhannya terus meningkat. Salah satu kendala utama pada budi daya kedelai ialah penyakit tular benih membisul oleh bakteri Xanthomonas axonopodis pv. glycine. Penelitian ini bertujuan mengevaluasi perlakuan panas kering dan ekstrak rimpang lengkuas terhadap penekanan populasi X. axonopodis pv. glycine dan vigor benih kedelai yang terinfeksi bakteri. Penelitian disusun dalam rancangan acak lengkap. Percobaan pertama ialah perlakuan panas kering pada suhu 45 ℃ dengan waktu pemanasan 6, 12, dan 24 jam, serta kontrol tanpa pemanasan. Percobaan kedua ialah perendaman biji selama satu jam di dalam ekstrak rimpang lengkuas dengan konsentrasi 25%, 20%, dan 15%, serta kontrol (air). Peubah yang diamati ialah jumlah populasi bakteri, daya kecambah, vigor, dan viabilitas benih. Hasil penelitian menunjukkan bahwa perlakuan panas dan ekstrak rimpang lengkuas berpengaruh nyata terhadap penurunan populasi X. axonopodis terbawa benih kedelai. Perlakuan benih kedelai dengan panas kering selama 24 jam menyebabkan benih bebas dari X. axonopodis, tetapi perkecambahan dan vigor benih mengalami penurunan. Sementara perlakuan benih dengan ekstrak rimpang lengkuas 25% menyebabkan populasi X. axonopodis menurun hingga 7.0 × 102 cfu mL-1, dengan tidak memengaruhi vigor dan viabilitas kedelai. Hasil penelitian mengindikasikan bahwa perlakuan panas kering memiliki potensi lebih baik dibandingkan dengan ekstrak rimpang lengkuas dalam mengeleminasi X. axonopodis dalam benih kedelai. Namun, karena perlakuan panas memiliki dampak negatif terhadap perkecambahan benih maka perlu dicari suhu dan waktu pemanasan yang optimal untuk menekan populasi X. axonopodis tanpa mengurangi viabilitas benih.
It is like a friend to me: Critical usage of automated feedback systems by self-regulating English learners in higher education
Authors: Li Long , Kim Mira 
Published: January 2024

This paper explores international students’ engagement with educational technology for self-regulated English learning at an Australian university. Despite the increased use of automated feedback systems (AFSs) for language assessment, students’ critical engagement with them for independent learning remains under-researched. The study primarily employed a qualitative approach to understand the students’ preferred AFS tools and critical engagement throughout their personalised learning journeys but it also included a small-scale quantitative component. Data were gathered from seven students’ e-portfolios, focus group interviews as well as a survey among 32 participants. Results highlight positive perceptions and successful use of AFSs, with students leveraging these tools to identify improvement areas, track progress and gain confidence. The study emphasises the importance of course structure, teacher guidance and a combination of human and automated feedback, in fostering learner autonomy and emotional self-regulation. The paper underscores the potential for sustained use of AFSs beyond the cours, and the significance of guiding learners to critically use these tools for ongoing learning and growth rather than dependence. These findings have significant implications, as readily available artificial intelligence tools such as ChatGPT hold great pedagogical potential for self-regulated learning within and beyond the language learning field.

Implications for practice or policy

Instructors can use AFSs as effective tools to help English learners in higher education when scaffolding critical engagement with automated feedback and emotional self-regulation and providing adaptability, as such scaffolding and flexibility are essential for mitigating the limitations of AFSs.
Course leaders and universities should consider investing in AFSs as they can elevate the availability and sustainability of feedback for language enhancement and potentially any other type of learning.
Development of a superstructure optimization framework with heat integration for the production of biodiesel
Authors: Huynh Thien An , Franke Meik B. , Zondervan Edwin 
Published: January 2024

Abstract
This work presents a superstructure for maximizing the annual profit of biodiesel production with Advanced Interactive Multidimensional Modeling System (AIMMS). The novelty features are the combination of pinch-based heat integration with a wide range of biodiesel feedstocks and the application of superstructure to evaluate the effect of uncertainties on the optimized design. The case study is a pilot refinery with the infeed capacity of 8000 tonnes feedstock per year. The biodiesel production route from tallow with reactive distillation technology and a heterogeneous acid catalyst has the highest total annual profit of 3.5 million USDs. The heating and cooling utilities can be reduced by 30 % with the heat integration. The result from the sensitivity analysis shows that the biodiesel and feedstock prices, and the production capacity have the most pronounced effects. From technical assessment, the reactive distillation process is the best choice for biodiesel production from different feedstocks.