bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter Identification of the Lagrangian-averaged Vorticity Deviation Vortex Detection Method Through the Investigation of Fluid Flow Around Solid Bodies
Authors: Kovács Kinga Andrea , Balla Esztella 
Published: October 2023

The main focus of the current paper is the detection of vortices in fluid flow around a circular cylinder and a square cylinder, with an emphasis on the identification of the parameters used for vortex detection. The authors aim to enhance the practicality of an existing vortex detection method (Lagrangian-averaged vorticity deviation) by providing recommendations for the settings of the vortex detection parameters. The simulations were carried out using ANSYS Workbench 2022 R2, encompassing Reynolds numbers between 12 and 140, and angles of incidence from 0° to 45°. The vortex detection was performed using MATLAB R2020b. The paper provides a comprehensive description of the parameters involved in the detection process and their significance, as well as the implementation of the parameter identification. The study results in the determination of the suggested parameter ranges, and a comparative analysis of different vortex detection methods is also presented for the case of the circular cylinder.
Afectación del derecho al descanso producto de la hiperconectividad laboral
Authors: Bravo Vintimilla Daniel Santiago , Pozo Cabrera Enrique Eugenio 
Published: October 2023

Introducción. El presente artículo abordó la problemática de la vulneración del derecho al descanso en Ecuador debido a una regulación insuficiente de la desconexión digital. A través de una metodología cualitativa y diversa, se examinan tanto los antecedentes históricos del tema como sus implicaciones actuales, basándose en distintos métodos como el histórico-lógico, deductivo-inductivo, analítico-sintético y dogmático. Mediante la revisión bibliográfica, se evidencia la necesidad urgente de una intervención legislativa que salvaguarde los derechos de los trabajadores en esta era digital. Vivimos en una era digital, donde la tecnología se ha integrado en casi todos los aspectos de nuestras vidas. Sin embargo, esto ha traído consigo nuevos desafíos, entre ellos, la inadecuada regulación de la desconexión digital en el Ecuador. Esta falta de regulación adecuada pone en riesgo el derecho fundamental al descanso de los trabajadores. Objetivo. Por lo tanto, el objetivo es analizar la vulneración del derecho al descanso en Ecuador debido a la inadecuada regulación de la desconexión digital. Metodología. Se adoptó un enfoque cualitativo, haciendo uso de diversos métodos: histórico-lógico para analizar los antecedentes y evolución del tema, deductivo-inductivo para transitar de conceptos generales a particularidades, analítico-sintético para abordar los efectos y problemas jurídicos derivados de la regulación actual y, finalmente, el método dogmático para sustentar teóricamente el tema. La técnica fue la revisión bibliográfica. Resultados. Se determinó que la regulación actual en Ecuador sobre la desconexión digital es insuficiente, lo que lleva a la vulneración de diversos derechos de los trabajadores. Conclusión. En este contexto, es imperativo que el legislador ecuatoriano intervenga para garantizar una regulación adecuada de la desconexión digital, protegiendo así el derecho al descanso de los trabajadores y adaptándose a las demandas de la era digital. Se sugiere considerar este tema como un nuevo derecho en proceso de construcción y desarrollo. Área de estudio general: Derecho. Área de estudio específica: Derecho constitucional.
Eficacia del uso de probióticos como profilaxis en pacientes con encefalopatía hepática de cambios mínimos
Authors: Toaza Gutama Diana Carolina , Orellana Bernal Paola Verónica 
Published: October 2023

Introducción. la encefalopatía hepática de cambios mínimos es la presentación más leve que se caracteriza por alteraciones subclínicas inespecíficas que no son evidentes mediante la exploración física, la cual se debe a la incapacidad del hígado de eliminar las toxinas originadas en el intestino siendo el amoniaco la principal toxina , en la actualidad se considera que los probióticos representan un gran avance en esta patología, la misma que va actuar disminuyendo la cantidad de microorganismos patógenos facilitando el exceso de amoniaco a nivel cerebral. Objetivo. describir la eficacia de los probióticos como profilaxis secundaria en pacientes con encefalopatía hepática de cambios mínimos. Metodología. es un estudio de revisión bibliográfica tipo narrativa, una revisión amplia de la literatura, sobre la eficacia del uso de probióticos como profilaxis en pacientes con encefalopatía hepática de cambios minimos en bases de datos científicas, como Pub Med, Scielo, Biblioteca Cochrane, y Science Direct, mediante parte de la estrategia PRISMA. Resultados. se revisaron 51 estudios, que recopilaron las principales recomendaciones sobre la importancia del diagnóstico del streptococo b hemolitico en el embarazo en bases de datos científicas, como Pub Med, Scielo, Biblioteca Cochrane, y Science Direct, mediante parte de la estrategia PRISMA. Conclusión. el empleo de probióticos ha demostrado tener efectos positivos en el manejo y prevencion de la encefalopatia hepatica de cambios minimos, principalmente cuando se emplean en diferentes combinaciones de varias cepas bacterianas y otros farmacos coadyucantes. Ademas se debe destacar que son economicos y de facil acceso, los estudios planteadoos exponen su eficiacia en el tratamiento de diferentes hepatopatías, así como en la prevención de las complicaciones de la cirrosis, debido a su capacidad para modular la flora intestinal, la permeabilidad intestinal y la respuesta inmune. Área de estudio general: medicina. Área de estudio específica: medicina general.
Factores sociales que provocan la mendicidad en niños, niñas y adolescentes en la ciudad de Cuenca – Ecuador
Authors: Paladines Coello Giovanna Jamileth , Quichimbo Sapatanga Martha Isabel , Tapia Segarra Jenny Irlanda 
Published: October 2023

Introducción. La mendicidad es un problema de carácter social que está vinculado directamente con la desigualdad y la pobreza. Se convierte en un factor de desigualdad social al considerarse que surge en base a la carencia de recursos socioeconómicos dentro de una familia. La situación de mendicidad en los niños, niñas y adolescentes se fundamenta en problemas como: Movilidad humana y la escasa oportunidad laboral. Objetivo. La presente investigación tiene por objetivo identificar los factores sociales que provocan la mendicidad en niños, niñas y adolescentes, en la Fundación Ciudadanos en Acción en la ciudad de Cuenca. Metodología. Para dar respuesta al objetivo se utilizó una metodología cuantitativa de tipo descriptiva siendo su diseño no experimental. Resultados. Los resultados obtenidos determinan que los factores sociales, especialmente, la escasa oportunidad laboral, repercuten de forma significativa en la estructura familiar generando de esa manera actividades de mendicidad. Conclusión. Las conclusiones indican que tanto la movilidad humana como las oportunidades de empleo constituyen causas de mendicidad infantil, puesto que los niños, niñas y adolescentes sienten la necesidad de apoyar a sus familias utilizando este medio para obtener dinero y alimentos. Por todo esto se recomienda el desarrollo de estrategias integras que promuevan el empleo digno, el acceso a la educación y la protección social, brindando a los NN/A y a sus progenitores una oportunidad para un futuro más seguro y próspero. Área de la ciencia: Trabajo Social
Acarine species associated with subterranean termites (Blattodea, Termitidae)
Authors: Bhadran Anjitha K , Ramani N. 
Published: October 2023

Ten species of mites were found associated with three species of termites, viz, Odontotermes obesus Rambur, 1842, O. feae Wasmann, 1896 and Nasutitermes gardneri Snyder, 1933. The collected mite species conformed to nine genera, four families and two orders. Among the ten species collected, nine of them were from the order Sarcoptiformes and cohort Astigmatina, while only one belonged to the order Trombidiformes. Seven species collected conformed to the family Acaridae. All mite species exhibited a phoretic relationship with their respective host insects. One adult mite, Premicrodispus paramaevi Hosseininaveh and Hajiqanbar, 2015 and nine deutonymphs were collected and described.
Study of the antimicrobial activity of cationic carbosilane dendrimers against clinical strains of multidrug-resistant bacteria and their biofilms
Authors: Hernando-Gozalo Marcos , Aguilera-Correa John Jairo , Rescalvo-Casas Carlos , Seijas-Pereda Laura , García-Bertolín Carlos , de la Mata Francisco Javier , Sánchez-Nieves Javier , Cuadros Juan , Pérez-Tanoira Ramón 
Published: October 2023

IntroductionAntimicrobial Resistance is a serious public health problem, which is aggravated by the ability of the microorganisms to form biofilms. Therefore, new therapeutic strategies need to be found, one of them being the use of cationic dendritic systems (dendrimers and dendrons).MethodsThe aim of this study is to analyze the in vitro antimicrobial efficacy of six cationic carbosilane (CBS) dendrimers and one dendron with peripheral ammonium groups against multidrug-resistant bacteria, some of them isolated hospital strains, and their biofilms. For this purpose, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC) and minimum eradication biofilm concentration (MBEC) studies were carried out. In addition, the cytotoxicity on Hela cells of those compounds that proved to be the most effective was analyzed.ResultsAll the tested compounds showed in vitro activity against the planktonic forms of methicillin-resistant Staphylococcus aureus and only the dendrimers BDSQ017, BDAC-001 and BDLS-001 and the dendron BDEF-130 against their biofilms. On the other hand, only the dendrimers BDAC 001, BDLS-001 and BDJS-049 and the dendron BDEF-130 were antibacterial in vitro against the planktonic forms of multidrug-resistant Pseudomonas aeruginosa, but they lacked activity against their preformed biofilms. In addition, the dendrimers BDAC-001, BDLS-001 and BDSQ-017 and the dendron BDEF-130 exhibited a good profile of cytotoxicity in vitro.DiscussionOur study demonstrates the possibility of using the four compounds mentioned above as possible topical antimicrobials against the clinical and reference strains of multidrug-resistant bacteria.
Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study
Authors: Tan Li , Zhong Meng-Mei , Zhao Ya-Qiong , Zhao Jie , Dusenge Marie Aimee , Feng Yao , Ye Qin , Hu Jing , Ou-Yang Ze-Yue , Chen Ning-Xin , Su Xiao-Lin , Zhang Qian , Liu Qiong , Yuan Hui , Wang Min-Yuan , Feng Yun-Zhi , Guo Yue 
Published: October 2023

Background: Regarding past epidemiological studies, there has been disagreement over whether type 1 diabetes (T1DM) is one of the risk factors for dental caries. The purpose of this study was to determine the causative links between genetic susceptibility to T1DM, glycemic traits, and the risk of dental caries using Mendelian randomization (MR) approaches.Methods: Summary-level data were collected on genome-wide association studies (GWAS) of T1DM, fasting glucose (FG), glycated hemoglobin (HbA1c), fasting insulin (FI), and dental caries. MR was performed using the inverse-variance weighting (IVW) method, and sensitivity analyses were conducted using the MR-Egger method, weighted median, weighted mode, replication cohort, and multivariable MR conditioning on potential mediators.Results: The risk of dental caries increased as a result of genetic susceptibility to T1DM [odds ratio (OR) = 1.044; 95% confidence interval (CI) = 1.015–1.074; p = 0.003], with consistent findings in the replication cohort. The relationship between T1DM and dental caries was stable when adjusted for BMI, smoking, alcohol intake, and type 2 diabetes (T2DM) in multivariable MR. However, no significant correlations between the risk of dental caries and FG, HbA1c, or FI were found.Conclusion: These results indicate that T1DM has causal involvement in the genesis of dental caries. Therefore, periodic reinforcement of oral hygiene instructions must be added to the management and early multidisciplinary intervention of T1DM patients, especially among adolescents and teenagers, who are more susceptible to T1DM.
Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity
Authors: Berentschot Julia C. , Drexhage Hemmo A. , Aynekulu Mersha Daniel G. , Wijkhuijs Annemarie J. M. , GeurtsvanKessel Corine H. , Koopmans Marion P. G. , Voermans Jolanda J. C. , Hendriks Rudi W. , Nagtzaam Nicole M. A. , de Bie Maaike , Heijenbrok-Kal Majanka H. , Bek L. Martine , Ribbers Gerard M. , van den Berg-Emons Rita J. G. , Aerts Joachim G. J. V. , Dik Willem A. , Hellemons Merel E. 
Published: October 2023

BackgroundMany patients with SARS-CoV-2 infection develop long COVID with fatigue as one of the most disabling symptoms. We performed clinical and immune profiling of fatigued and non-fatigued long COVID patients and age- and sex-matched healthy controls (HCs).MethodsLong COVID symptoms were assessed using patient-reported outcome measures, including the fatigue assessment scale (FAS, scores ≥22 denote fatigue), and followed up to one year after hospital discharge. We assessed inflammation-related genes in circulating monocytes, serum levels of inflammation-regulating cytokines, and leukocyte and lymphocyte subsets, including major monocyte subsets and senescent T-lymphocytes, at 3-6 months post-discharge.ResultsWe included 37 fatigued and 36 non-fatigued long COVID patients and 42 HCs. Fatigued long COVID patients represented a more severe clinical profile than non-fatigued patients, with many concurrent symptoms (median 9 [IQR 5.0-10.0] vs 3 [1.0-5.0] symptoms, p&lt;0.001), and signs of cognitive failure (41%) and depression (&gt;24%). Immune abnormalities that were found in the entire group of long COVID patients were low grade inflammation (increased inflammatory gene expression in monocytes, increased serum pro-inflammatory cytokines) and signs of T-lymphocyte senescence (increased exhausted CD8+ TEMRA-lymphocytes). Immune profiles did not significantly differ between fatigued and non-fatigued long COVID groups. However, the severity of fatigue (total FAS score) significantly correlated with increases of intermediate and non-classical monocytes, upregulated gene levels of CCL2, CCL7, and SERPINB2 in monocytes, increases in serum Galectin-9, and higher CD8+ T-lymphocyte counts.ConclusionLong COVID with fatigue is associated with many concurrent and persistent symptoms lasting up to one year after hospitalization. Increased fatigue severity associated with stronger signs of monocyte activation in long COVID patients and potentially point in the direction of monocyte-endothelial interaction. These abnormalities were present against a background of immune abnormalities common to the entire group of long COVID patients.
Concurrent coronary artery disease and immune thrombocytopenia: a systematic review
Authors: Rahhal Alaa , Provan Drew , Shunnar Khaled , Najim Mostafa , Ahmed Ashraf Omer , Rozi Waail , Al-Khabori Murtadha , Marashi Mahmoud , AlRasheed Mona , Osman Hani , Yassin Mohamed 
Published: October 2023

IntroductionCoronary artery disease (CAD) management in the setting of immune thrombocytopenia (ITP) remains very challenging to clinicians as a reasonable balance between bleeding and thrombosis risks needs to be achieved, and the evidence guiding such management is scarce.MethodsWe conducted a systematic review following the PRISMA guidelines to summarize the available literature on the management and outcomes of CAD coexisting with ITP. We searched PubMed and Embase for studies published in English exploring CAD and ITP management until 05 October 2022. Two independent reviewers screened and assessed the articles for inclusion. Patients' characteristics, CAD treatment modalities, ITP treatment, and complications were reported.ResultsWe identified 32 CAD cases, among which 18 cases were revascularized with percutaneous coronary intervention (PCI), 12 cases underwent coronary artery bypass graft surgery (CABG), and two cases were managed conservatively. More than 50% were men, with a mean age of 61 ± 13 years and a mean baseline platelet count of 52 ± 59 × 109/L. Irrespective of the revascularization modality, most patients were treated with either corticosteroids alone, intravenous immunoglobulins (IVIG) alone, or in combination. Among those who underwent PCI, two patients had bleeding events, and one patient died. Similarly, among those with CABG, one patient developed bleeding, and one patient died.ConclusionWe found that revascularization with either PCI or CABG with the concurrent use of corticosteroids and/or IVIG for ITP was feasible, with an existing non-negligible risk of bleeding and mortality.
Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature
Authors: Sadlon Angélique , Ott Martin , Kressig Reto W. 
Published: October 2023

IntroductionPatients who should benefit from anti-amyloid therapies (AAT) are found across all geriatric settings. Yet, it remains unclear how the use of AAT in patients with geriatric syndromes, such as frailty and polypharmacy, has so far been discussed in the literature.MethodsArticles on aducanumab, gantenerumab, lecanemab, donanemab, crenezumab, solanezumab were retrieved in MEDLINE from inception to July 2023. For each article, identified geriatric relevant terms were assigned to five discussion contexts (eligibility of AAT study population, safety, prescription, patient clinical profile, alternative outcomes measurement). Article type and the involvement of geriatric healthcare professionals as an author were further extracted.ResultsOut of 538 articles, 23 (4.27%) were published in journals from the geriatric category, 44 (8.18%) included an author affiliated with a geriatric institution. One hundred and sixteen (21.56%) articles included at least one geriatric relevant term, which were mostly discussed in the context of safety and eligibility. Articles mentioning geriatric syndromes were more frequently authored by a geriatric healthcare professional (p = 0.044).DiscussionThe use of AAT in patients with geriatric syndromes has so far received poor attention in the literature raising concerns on their use in this patient group. The involvement of geriatric healthcare professionals in future studies may increase the relevance of AAT research in patients with geriatric syndromes.
Middle meningeal artery embolization for chronic subdural hematoma: a systematic review
Authors: Omura Yoshihiro , Ishiguro Taichi 
Published: October 2023

BackgroundChronic subdural hematoma (cSDH) is one of the most common diseases in neurosurgery. Middle meningeal artery embolization (MMAE) is reportedly an option to prevent recurrence or avoid surgery in patients with cSDH. This study was performed to review the evidence on MMAE for cSDH and evaluate its safety, efficacy, indications, and feasibility.MethodsWe systematically reviewed the literature according to the PRISMA guidelines using an electronic database. The search yielded 43 articles involving 2,783 patients who underwent MMAE.ResultsThe hematoma resolution, recurrence, and retreatment rates in the MMAE-alone treatment group (n = 815) were 86.7%, 6.3%, and 9.6%, respectively, whereas those in the prophylactic MMAE with combined surgery group (n = 370) were 95.6%, 4.4%, and 3.4%, respectively. The overall MMAE-related complication rate was 2.3%.ConclusionThis study shows that MMAE alone is, although not immediate, as effective as evacuation surgery alone in reducing hematoma. The study also shows that combined treatment has a lower recurrence rate than evacuation surgery alone. Because MMAE is a safe procedure, it should be considered for patients with cSDH, especially those with a high risk of recurrence.
The impact of patient-reported visual disturbance on dynamic visual acuity in myopic patients after corneal refractive surgery
Authors: Wang Yuexin , Zhang Yu , Wu Tingyi , Ren Xiaotong , Yuan Yifei , Li Xuemin , Chen Yueguo 
Published: October 2023

PurposeTo investigate the impact of patient-reported visual disturbance on dynamic visual acuity in myopic patients after corneal refractive surgery.MethodsThis is a prospective nonrandomized study. Adult myopic patients receiving bilateral photorefractive keratectomy (PRK), femtosecond laser-assisted in situ keratomileusis (FS-LASIK), or small incision lenticule extraction (SMILE) with Plano target were included. Eight types of patient-reported visual disturbance were evaluated regarding frequency, severity and bothersome and dynamic visual acuity (DVA) of 40 and 80 degrees per second (dps) was measured postoperatively at 3 months.ResultsThe study enrolled 95 patients with an average age of 27.6 ± 6.4 years. The most frequently reported visual disturbance was the fluctuation in vision (70.5%), followed by glare (66.3%) and halo (57.4%). Postoperative DVA at 80 dps was significantly associated with the total score of haloes (p = 0.038) and difficulty in judging distance (p = 0.046). Significant worse postoperative DVA at 40 dps was observed in patients with haloes than those without (p = 0.024). The DVA at 80 dps for patients without haloes or difficulty in judging distance was significantly better than that with the symptoms (haloes, p = 0.047; difficulty in judging distance, p = 0.029). Subgroup analysis by surgical procedures demonstrated that the significant difference in DVA between patients with and without visual disturbance was only observed in patients receiving FS-LASIK.ConclusionPostoperatively, myopic patients undergoing corneal refractive surgery with haloes or difficulty in judging distance have significantly worse low and high-speed DVA than those without the symptoms. The present study provided the basis for postoperative guidance in daily tasks involving dynamic vision when patients have visual disturbances.