bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent results on proton charge radius and polarizabilities
Authors: Gao Haiyan , Zhou Jingyi 
Published: December 2023

Abstract
The proton charge radius and nucleon electromagnetic polarizabilities are fundamental properties probing the electromagnetic structure of the nucleons. Proton charge radius is directly related to the proton charge distribution and the nucleon electromagnetic polarizabilities characterize the response of the charge/magnetic constituents inside the nucleon to external electromagnetic fields. A precise understanding of these quantities is crucial not only for understanding how Quantum Chromodynamics (QCD) works in the non-perturbative QCD region but also for bound state Quantum Electrodynamics (QED) calculations of atomic energy levels. We discuss the experimental approaches employed in the recent decades to determine the proton charge radius and nucleon electromagnetic polarizabilities. We summarize the present status of the proton charge radius puzzle and polarizabilities measurements. Additionally, we provide prospects for various upcoming experiments.
Research on Mountain Highway Slope Stability in Wenzhou area
Authors: Liu Mingqing , Chen Fan , Chen Li , Fu Jianye 
Published: December 2023

Abstract
In order to study the stability of highway slopes in the mountainous areas of southern Zhejiang, this paper takes the highway slopes in Wenzhou area as a representative, and uses the research methods of investigation and statistics, indoor experiments and numerical simulation to study the stability laws of highway slopes in mountainous areas. Through investigation and statistics, the safety and stability of highway slopes are understood, and the geotechnical parameters and shear performance parameters of typical slope soil are obtained through indoor experiments. Using the obtained geotechnical parameters, the binary slope stability of upper soil and lower rock is numerically simulated by finite element software, and the relevant laws of slope stability in Wenzhou area are obtained. The research results of this paper can provide technical support for the stability protection and treatment of highway slopes and engineering disaster prevention in this region, and can also provide reference for similar projects in southern Zhejiang.
Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study
Authors: Kurosawa Shuhei , Shimomura Yoshimitsu , Ishiyama Ken , Fuse Kyoko , Shimazu Yutaka , Doki Noriko , Uchida Naoyuki , Tanaka Masatsugu , Takahashi Satoshi , Sakurai Masatoshi , Kobayashi Hikaru , Katayama Yuta , Takada Satoru , Ozeki Kazutaka , Nakamae Hirohisa , Ishimaru Fumihiko , Kanda Yoshinobu , Ichinohe Tatsuo , Atsuta Yoshiko , Itonaga Hidehiro 
Published: December 2023

Abstract
Chronic myelomonocytic leukaemia (CMML) is a haematological malignancy with a poor prognosis. Allogeneic haematopoietic stem cell transplantation remains the only curative approach. Without human leukocyte antigen-matched related sibling donors, the optimal alternative donor has yet to be established. Although unrelated bone marrow transplantation (UBMT) has been extensively studied, cord blood transplantation (CBT) for CMML remains largely unexplored. This nationwide retrospective study compared the outcomes of UBMT and single-unit umbilical CBT in patients with CMML. This study included 118 patients who underwent their first allo-HSCT during 2013–2021. Of these, 50 received BMT (UBMT group), while 68 underwent CBT (CBT group). The primary endpoint was the 3-year overall survival (OS). There were comparable 3-year OS rates between the UBMT (51.0%, 95% confidence interval [CI]: 34.1–65.5%) and CBT (46.2%, 95% CI: 33.2–58.1%; P = 0.60) groups. In the inverse probability of treatment weighting analysis, CBT did not show significantly improved outcomes compared with UBMT regarding the 3-year OS rate (hazard ratio 0.97 [95% CI: 0.57–1.66], P = 0.91). Thus, CBT may serve as a promising alternative to UBMT for patients with CMML. Further research is necessary to optimise transplantation strategies and enhance outcomes in patients with CMML undergoing CBT.
A comparative analysis of BI-RADS and the Japanese Recall Criteria and Categorization in breast ultrasound screening
Authors: Hayashida Tetsu , Nagayama Aiko , Seki Tomoko , Takahashi Maiko , Yokoe Takamichi , Maeda Naoko , Shikida Hidemi , Futatsugi Noriyuki , Matsumoto Akiko , Yamada Miki , Murata Takeshi , Watanuki Rurina , Nakashoji Ayako , Maeda Hinako , Onishi Tatsuya , Asaga Sota , Hojo Takashi , Jinno Hiromitsu , Sotome Keiichi , Matsui Akira , Suto Akihiko , Imoto Shigeru , Kitagawa Yuko 
Published: December 2023

Abstract
Background Japan widely utilizes breast ultrasound screening and the Japanese Recall Criteria and Categorization (JRCC) to identify breast cancer cases, while other countries commonly employ the Breast Imaging Reporting and Data System (BI-RADS). The differences between the two systems have not been thoroughly investigated.
Methods This study analyzed 3,113 lesions in 2,000 breast ultrasound images with confirmed diagnoses and compared the accuracy and disparities between JRCC and BI-RADS.
Results Among patients who were not recalled under BIRADs, 94 (16.2%) patients were assigned to recall under JRCC whereas among patients who were not recalled under JRCC, 332 (40.6%) patients were assigned to recall. Of the 423 BI-RADS 4a and 528 BI-RADS 4b cases, 264 (62.4%) and 68 (12.8%) would not have been recalled under JRCC, of which 9 (2.1%) and 22 (4.2%) were diagnosed as malignant, respectively. Of the 579 cases classified as BI-RADS 3 or lower, only two (0.35%) were diagnosed with breast cancer, while 33 of the 817 cases (4.04%) classified as JRCC 2 or lower were malignant. The sensitivity and the specificity of BI-RADS were 99.9% and 40.0% while those of JRCC were 98.0% and 54.3%, respectively. While JRCC exhibited higher specificity, it also showed lower sensitivity and false-negative rates. If the threshold for BI-RADS was changed from 4a or higher to 4b or higher, the sensitivity and specificity for diagnosing malignancy would be 99.0% and 68.3%, respectively, surpassing those for JRCC.
Conclusions It is important to understand the differences between JRCC and BI-RADS and translate screening results from other countries.
A comprehensive functional analysis indicates CNDP1 mitigates hepatocellular carcinoma and may be associated with immune cell infiltration and m6A-related genes
Authors: Wen Chong , Shi Ruolin , An Yulong , Zhang Shuting , Wang Tao , Luo Hao 
Published: December 2023

Abstract
Background
Carnosine dipeptidase 1 (CNDP1) is a member of the dipeptidase family that hydrolyzes the substrate L-sarcosine, and its relationship with hepatocellular carcinoma (HCC) has not been previously reported. We aim to explore the expression of CNDP1 in HCC and its relationship with prognosis.
Methods
Online analysis tools and the TCGA database were used to identify CNDP1 expression, correlation analysis, functional enrichment analysis, and patient prognosis analysis. Lentiviral transfection was used to construct two HCC cell lines (Sk-hep-1 and Huh-7) with high CNDP1 expression and knockdown. Transwell assay, wound healing assay, Cell proliferation assay, and subcutaneous xenograft assay were used to evaluate the invasion, migration, proliferation, and tumorigenesis of the experimental HCC cells, respectively.
Results
CNDP1 is down-regulated in HCC tissues, and low CNDP1 results in poor overall survival (OS) and disease-specific survival (DSS). The expression of CNDP1 was correlated with the infiltration level of various m6A-related genes and immune cells in HCC tissues. Cell and animal experiments confirmed that the expression of CNDP1 was decreased in Sk-hep-1 and Huh-7 HCC cell lines and the migration, proliferation, invasion, and tumor formation ability of HCC cell lines in the CNDP1-overexpression groups was weakened, while that in the knockdown groups was enhanced.
Conclusion
The decreased expression of CNDP1 in HCC suggests a worse prognosis and may be associated with immune cell infiltration and m6A-related genes. Our findings suggest that CNDP1 may be a new target for the diagnosis and treatment of HCC.
The Association between Blood Pressure Control and Multiple Self-Management Behaviors in Elderly Patients with Hypertension: A Study Based on Latent Class Analysis
Authors: Liu Mengya , Zhang Tianli , Guo Wenjing , Chang Yuqing , Zhao Siyi , Zhang Meng , Zhang Li 
Published: December 2023

Abstract
Background
Hypertension in elderly people has become one of the major challenges in China due to the acceleration of population aging. There are few studies on the self-management behavior of elderly people with hypertension. Elderly people with hypertension are a unique group, and self-management behavior is heterogeneous among different groups of individuals. The present study explored the latent class of self-management behaviors in elderly patients with hypertension and its association with blood pressure control.
Methods
Elderly individuals with hypertension who participated in a community health examination in the lakeside community of Bengbu City were selected as research subjects, and a physical examination and questionnaire survey were carried out. Latent class analysis was used to explore the self-management class of elderly patients with hypertension; the characteristics of self-management class were analyzed by a logistic regression model; and the relationship between self-management class and blood pressure control level was analyzed by multiple linear regression.
Results
A total of 3211 elderly patients with hypertension in the community were enrolled, and their self-management behaviors could be divided into four classes: comprehensive positive management (23.70%), positive exercise management (16.29%), comprehensive negative management (25.20%) and negative exercise management (34.81%). Logistic regression results showed that older age, male sex, widowhood, lower education levels, rural residence, and ADL limitations had greater associations with comprehensive negative management (P < 0.05). The results of multiple linear regression analysis showed that compared with comprehensive negative management, patients with positive exercise management and comprehensive positive management had better blood pressure control (positive exercise management: β = 0.059, t = 2.345, P = 0. 019; comprehensive positive management: β = 0.073, t = 2.603, P = 0. 009), suggesting that exercise plays an important role in blood pressure control in elderly hypertensive patients.
Conclusion
There is significant heterogeneity in the self-management behavior of elderly patients with hypertension, and community workers should respond as follows: identify the self-management characteristics and risk factors for various classes of patients as early as possible; formulate different treatment plans for different classes of elderly patients with hypertension; and provide corresponding intervention strategies to help them improve their awareness of self-management behavior, change their bad habits, and improve their quality of life.
Flexibility of gestural production in captive groups of chimpanzees (Pan troglodytes), Sumatran orangutans (Pongo abelii) and siamangs (Symphalangus syndactylus)
Authors: Amici Federica , Liebal Katja 
Published: December 2023

Abstract
Flexibility is an important hallmark of complex communication systems, yet few studies have systematically assessed it in non-human species. In this study, we investigated different aspects of flexibility in the gestural communication systems of 7 groups of captive apes (N = 53), including 19 chimpanzees (Pan troglodytes), 16 Sumatran orangutans (Pongo abelii) and 18 siamangs (Symphalangus syndactylus). We operationalized flexibility in four different ways: (i) the use of one gesture type across several contexts (i.e. contextual flexibility), (ii) the use of many gesture types in the same context, (iii) morphological variation with which individual gesture types can be produced (i.e. morphological flexibility), and (iv) the ability to combine signals into different sequences. Comparisons across individuals and species revealed variation in contextual and morphological flexibility. In particular, contextual flexibility increased through age, and it was overall higher in chimpanzees than in siamangs. However, morphological flexibility was highest in siamangs and lowest in orangutans. Overall, variation could be largely explained in terms of changes in social experience and differences in the socio-ecological characteristics of the species. Our findings suggest that contextual and morphological flexibility might be good candidates to study inter-individual and inter-specific variation in primate gestural production.
Do You Know Your Daily Antibiotic Intake through Residues in Your Diet?
Authors: Seo Jegak , Kloprogge Frank , Smith Andrew M. , Karu Kersti , Ciric Lena 
Published: December 2023

Abstract
While the use of a wide range of antibiotics has been reported as extensive in the rearing of agricultural animals, extremely limited information is available on the antibiotic residues in animal products and the adverse impact consistent low-level exposure to antibiotics might have on the human body as well as its microbiome. The aim of this study was to estimate the possible antibiotic concentrations humans are exposed to via their diet using the concentration of antibiotics in animal food products and water, and an online survey on dietary habits. A total of 131 participants completed the dietary habits survey, the majority belonging to the omnivorous diet habit. Distinct dietary trends were observed into omnivorous and unknown groups eating food-producing animal products, with specific food types dominating each meal: pork (e.g. ham) and dairy products (e.g. milk, yoghurt) during breakfast, beef (e.g. burger) and chicken (e.g. chicken breast) products during lunch, and fish (e.g. salmon fillet) during dinner. 34 different animal-based food and drink products were tested for the presence of ten different antibiotics. Of all products tested, over 35% exceeded the acceptable daily intake antibiotic concentration for amoxicillin, ampicillin, and enrofloxacin.
Mapping of soil erosion susceptibility using advanced machine learning models at Nghe An, Vietnam
Authors: Quyet Nguyen Chien , Thi Tran Tuyen , Thanh Thi Nguyen Trang , Ha Thi Nguyen Thuy , Astarkhanova T. S. , Van Vu Luong , Tai Dau Khac , Nguyen Hieu Ngoc , Pham Giang Hương , Nguyen Duc Dam , Prakash Indra , Pham Binh 
Published: December 2023

Abstract
Soil Erosion Susceptibility Mapping (SESM) is one of the practical approaches for managing and mitigating soil erosion. This study applied four Machine Learning (ML) models, namely the Multilayer Perceptron (MLP) classifier, AdaBoost, Ridge classifier, and Gradient Boosting classifier to perform SESM in a region of Nghe An province, Vietnam. The development of these models incorporated seven factors influencing soil erosion: slope degree, slope aspect, curvature, elevation, Normalized Difference Vegetation Index (NDVI), rainfall, and soil type. These factors were determined based on 685 identified soil erosion locations. According to SHapley Additive exPlanations (SHAP) analysis, soil type emerged as the most significant factor influencing soil erosion. Among all the developed models, the Gradient Boosting classifier demonstrated the highest prediction power, followed by the MLP classifier, Ridge classifier, and AdaBoost, respectively. Therefore, the Gradient Boosting classifier is recommended for accurate SESM in other regions too, taking into account the local geo-environmental factors.
Influence of Dispersion Interactions in the Diels-Alder Reaction of Cyclopentadiene,
Anthracene and Tetracene with C60: A DFT Examination
Authors: Masliy Alexey N. , Kuznetsov Andrey M. 
Published: December 2023

Asbtract:
The activation and thermodynamic parameters of the Diels-Alder reaction of
cyclopentadiene, anthracene and tetracene with C60 fullerene are estimated at the DFT level
using PBE0, B3LYP and CAM-B3LYP functionals and the effect of accounting for dispersion
interactions in various semi-empirical Grimme models on these parameters. Structural
characteristics of the reagents, products, pre-reaction van der Waals complex, and transition
state are obtained. Taking into account dispersion corrections have practically no effect on
the geometric characteristics of structures with the covalent type of the bond, as well as on
the structure of the transition state. Still, it has a noticeable effect only on the structure of
the pre-reaction complex, in which the interparticle interaction has a van der Waals character.
At the same time, taking into account dispersion corrections plays a significant role in
assessing the thermodynamic and activation parameters of the reaction. An analysis of the performed calculations
showed that the combination of PBE0/def2-TZVP with the D4 model for dispersion interactions could be
recommended for the Diels-Alder reaction considered above.
Correlation between Carotid Blood Flow Velocity and Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease in Patients
with Recent Small Subcortical Infarcts
Authors: Lv Yi-Jun , Zhang Qing-Xiu , LI Jing-Wei , Yun Wen-Wei , Zhang Min 
Published: December 2023

Background:
The common and internal carotid arteries are the upstream vessels of
the small cerebral vessels. The relationship between hemodynamic changes in the significant
cervical vessels and cerebral small vessel disease (CSVD) remains uncertain. This research
sought to analyze the correlation between carotid blood flow velocity and the total magnetic resonance
imaging (MRI) burden of CSVD in patients with recent small subcortical infarcts
(RSSIs).

Methods:
Data were gathered from individuals diagnosed with RSSIs admitted to Changzhou
Second People's Hospital between January 2022 and June 2023. Brain MRI was performed on
every patient to determine the overall MRI burden of CSVD, along with carotid duplex ultrasound
to evaluate carotid blood flow velocity and pulsatility index (PI) of the common carotid
(CCA) and internal carotid (ICA) arteries. The association between carotid blood flow velocity
and the total MRI load of CSVD was examined using univariate and multivariate analyses.

Results:
For our investigation, 272 individuals with RSSIs were screened. 82 individuals had a
moderate to severe load of CSVD, while 190 participants showed a mild burden. Patients with
moderate to severe burden of CSVD had lower end-diastolic velocity (EDV) and higher PI in
CCA and ICA than those with mild load (P < 0.001). After adjusting for variables like age, hypertension,
systolic blood pressure, and blood homocysteine levels, multivariate logistic regression
analysis showed that EDV in CCA (OR, 0.894; P = 0.011), PI in CCA (OR, 5.869; P =
0.017), EDV in ICA (OR, 0.909; P = 0.008), and PI in ICA (OR, 5.324; P = 0.041) were independently
related to moderate to severe CSVD burden. Spearman correlation analysis showed
that EDV in CCA and ICA was negatively related to the total MRI load of CSVD in patients
with RSSIs (P < 0.001). PI in CCA and ICA was positively associated with the whole MRI load
of CSVD (P < 0.001).

Conclusion:
Low carotid blood flow velocity and high carotid pulsatility index are independently
associated with moderate to severe burden of CSVD.
Improved Detection of Veterinary Drug Residues: Advancing Analytical Techniques to Ensure Food Safety
Authors: Fu Li , Zhu Jiangwei , Zhou Qingwei 
Published: December 2023

Abstract:
Veterinary drug residues in foods pose risks to consumers and promote antimicrobial resistance. Effective detection methods are needed to monitor and control residues. Recent advancements in analytical techniques for veterinary drug residue detection were reviewed. Key sample preparation methods, including QuEChERS, SPE, ASE, and LLE, were summarized. Instrumental analysis techniques including LC-MS/MS, GC-MS, immunoassays, CE and biosensors were examined. Recent trends and future directions were identified.

:
LC-MS/MS and GC-MS provide the highest sensitivity and specificity for veterinary drug residue analysis. However, selectivity remains a challenge, particularly for complex matrices like meat and liver. Multi-residue methods now cover over 100 analytes, but analyzing new and legacy drugs lacking established methods is difficult. Increased sensitivity has been achieved through UHPLC and high resolution MS, but detection limits below 1 μg/kg often remain elusive. sSimplified onsite tests are gaining interest.

:
More selective extraction strategies, data-driven multi-residue methods, microflow LC, and integrated analytical platforms may help address current challenges. Continued advances in sample preparation, instrumentation, data processing, and validation will be needed to fully realize the potential of veterinary drug residue detection and ensure food safety.
Role of Omega-3PUFA: A Nutraceutical for Brain Functioning and Treatment
of Mental Disorders
Authors: Garg Ishu , Kumari Raj , Sharma Meenakshi 
Published: December 2023

Abstract:
Concerning the past few years in terms of health and nature, the globe has witnessed an upsurge in the use of nutraceuticals and nutritional and
natural products in therapeutics. The major reason for this step is the conventional pharmacological treatment using synthetic drugs that do not
meet the status of health and therapeutic requirements for various pathological conditions. Nutraceuticals promise prominent health and therapeutic
benefits with no adverse or side effects, providing extra health benefits besides their action in any defined pathological condition. Nutraceuticals
are extensive biological therapies that include herbs, vitamins, fatty acids, prebiotics, and probiotics used to promote and maintain health to prevent
and cure pathological conditions, malignant processes, syndromes, and symptoms. Nutraceuticals have multidirectional therapeutic benefits and are
claimed to be effective products in aiding human health. The addition of omega-3 for the treatment of mental and mood disorders was found to
have safer, more valuable, and better therapeutic results in comparison to the use of synthetic drugs. Omega-3 is available in the regular diet
through soybeans, walnuts, codfish, and salmon fish, and its constituents have been found to play a promising role in brain development, including
brain aging and neurodegenerative disorders, in the pathology of mental and mood disorders, and treatment of the same. Supplementation with
Omega-3 PUFA provides a promising effect in better brain development, treatment, prevention and cure of mental and mood disorders. This
review endeavours to display and assert the clinical relevance of omega-3 PUFA in brain development, pathology, and treatment of mental and
mood disorders.