bluuebunny/crossref_metadata_2025_split huggingface dataset:
A compliance control strategy of lower‐limb exoskeletons for energy‐efficient stance‐squat transitions with a payload
Authors: Hsiao Tesheng , Yu Kai‐Jung 
Published: November 2023

AbstractThis paper proposes an admittance control algorithm for lower‐limb exoskeletons to assist able‐bodied wearers in performing energy‐efficient stance‐squat transitions while carrying a payload of up to 20 kg. A two‐degree‐of‐freedom (DOF) model dedicated to the stance‐squat transition is derived, which takes into account the wearer's torso inclination angle and the vertical displacement of the hip joint. The torso inclination angle is obtained from an inertial measurement unit (IMU) located at the backpack of the exoskeleton. In addition, the moment caused by the torso plus the payload with respect to the hip joint is estimated. Then a model‐based disturbance observer (DOB) is used to estimate the wearer's joint torque as an indication of the motion intention, and the exoskeleton complies with the intention by following the desired joint angular velocity generated from the estimated wearer's joint torque through an admittance function. Experiments with different admittance parameters are conducted, and the energy consumption of the wearer is evaluated in terms of the normalized energy consumption index (NECI) and the physiological cost index (PCI). Furthermore, experimental comparisons of energy consumption are made for a subject carrying a payload of up to 20 kg and performing repeated stance‐squat transitions with and without the exoskeleton. The results show that a 50% reduction of energy consumption (in terms of PCI) is achieved by the exoskeleton with the proposed admittance control strategy.
Impact of training on awareness and Knowledge of Birth Defects among Community Health Workers in tribal district of Maharashtra, India
Authors: Surve Suchitra , Kulkarni Ragini , Gawai Priyanka , Salvi Neha , Begum Shahina , Bodade Sanjay , Suryawanshi Dayanand , Chavan Milind , Pachalkar Ujwal , Pagi Pradeep , Chauhan Sanjay 
Published: November 2023

AbstractObjectiveEarly identification, referrals and timely treatment is crucial to improve the outcome of Birth Defects (BDs). The role of Community Health Workers (CHWs) in India is largely fulfilled by Accredited Social Health Activists (ASHAs) who can play an important role in community‐based reporting and referrals of BDs in newborn. In the study area, ASHAs have been previously trained for identification of BDs under Rashtriya Bal Swasthya Karyakram (RBSK); however, reporting through them was found to be sub‐optimal.MethodsTo strengthen the community based reporting of BDs through ASHAs, audio visual based training was provided to 1225 ASHAs in 6 tribal blocks of Palghar district in Maharashtra, India. The change in knowledge about BDs before and after training among 1023 participants was analyzed using paired sample t test & McNemar test.ResultsFindings reveal a significant increase in the knowledge of participants with regards to prevention, risk factors and identification of BDs after intervention as compared to before intervention.DiscussionThe study suggests that audio‐visual based refresher training increased knowledge of ASHAs with respect to identification, prevention and risk factors of BDs which may eventually improve reporting and referrals of BDs at community level.
Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting‐state fMRI study
Authors: Jiang Wen‐tao , Liu Xia , Xu Zi‐yun , Zhou Zhi‐feng , Tie Chang‐jun , Liu Xiao‐ying , Yang Ji‐hui , Li Hai , Lai Wen‐tao 
Published: November 2023

AbstractBackgroundGaming behavior can induce cerebral changes that may be related to the neurobiological features of gaming disorder (GD). Additionally, individuals with higher levels of depression or impulsivity are more likely to experience GD. Therefore, the present pilot study explored potential neurobiological correlates of GD in the context of depression and impulsivity, after accounting for video gaming behavior.MethodsUsing resting‐state functional magnetic resonance imaging (fMRI), a cross‐sectional study was conducted with 35 highly involved male adult gamers to examine potential associations between GD severity and regional homogeneity (ReHo) in the entire brain. A mediation model was used to test the role of ReHo in the possible links between depression/impulsivity and GD severity.ResultsIndividuals with greater GD severity showed increased ReHo in the right Heschl's gyrus and decreased ReHo in the right hippocampus (rHip). Furthermore, depression and impulsivity were negatively correlated with ReHo in the rHip, respectively. More importantly, ReHo in the rHip was found to mediate the associations between depression/impulsivity and GD.ConclusionsThese preliminary findings suggest that GD severity is related to ReHo in brain regions associated with learning/memory/mood and auditory function. Higher levels of depression or impulsivity may potentiate GD through the functional activity of the hippocampus. Our findings advance our understanding of the neurobiological differences behind GD symptoms in highly involved gamers.
From green hype to green habits: Understanding the factors that influence young consumers' green purchasing decisions
Authors: Lopes João M. , Pinho Micaela , Gomes Sofia 
Published: November 2023

AbstractIt is believed that environmental causes will grow in fervor with members of Gen Z. This study explores the main factors of green marketing affecting young Portuguese green purchasing decisions and the relationship between them. An online questionnaire was used to collect data from 708 young Portuguese consumers of eco‐friendly products. The quantitative analysis was performed using the partial least square (PLS) method. We found that the marketing factors of green willingness to purchase, green awareness of price, green perceived benefits, and green perceived quality were positively associated with young peoples' environmental concerns, and they also proved to be positively related to their green purchasing decisions when mediated by the environmental concern variable. This study contributes to the literature on green marketing, having empirically evaluated, for the first time, the role of environmental concerns as mediators of consumers' perceptions of green products and their purchase intentions. Furthermore, it pioneeringly explores the determinants of Generation Z's environmental concerns and green purchasing decisions, making an essential contribution to the literature on consumer behavior and generational cohorts. The breadth of influence of each determinant is not balanced, and producers, marketers, and policymakers must consider these results in their strategy of attracting young consumers to purchase green products.
Real‐world effectiveness and safety of RC48‐ADC alone or in combination with PD‐1 inhibitors for patients with locally advanced or metastatic urothelial carcinoma: A multicenter, retrospective clinical study
Authors: Xu Jingwei , Zhang Hongqiao , Zhang Li , Chu Xiufeng , Li Yu , Li Guangyuan , Nie Caiyun , Wang Meng , Guo Yanwei 
Published: November 2023

AbstractIntroductionPrevious RC48 (Disitamab Vedotin) studies established that the safety and efficacy of RC48‐antibody–drug conjugate (ADC), either alone or combined with toripalimab, for metastatic urothelial carcinoma (mUC) patients exhibiting human epidermal growth factor receptor 2 (HER2)‐positive or even HER2‐negative status after standard chemotherapy failure.MethodsWith locally advanced or metastatic urothelial carcinoma (la/mUC), patients who received RC48‐ADC monotherapy or a combination with programmed cell death protein 1 (PD‐1) inhibitors between August 2021 and October 2022 were enrolled in this retrospective observational study to evaluate the real‐world antitumor effectiveness and safety.ResultsAmong the 38 enrolled patients (29 males; median age 67.5 years [38–93]), 8 received RC48‐ADC monotherapy, while 30 received combination therapy. Initially, 63.2% (24/38) of the patients had received ≥1 line of prior treatment, and 63.2% (24/38) had visceral metastasis. UC of the bladder represented the majority type in 68.4% (26/38) of cases. By the data cutoff in March 2023, the overall objective response rate (ORR) was 63.2% (95% CI, 47.1%–79.2%), with a disease control rate (DCR) of 89.5% (95% CI, 79.3%–99.7%). Median follow‐up time was 10.6 months. The median progression‐free survival (PFS) was 8.2 months (95% CI, 5.9–10.5), with a 6‐month PFS rate of 63.2% and a 12‐month PFS rate of 34.1%. Median overall survival (OS) was not reached, with a 12‐month OS rate of 76.7%. The median duration of response was 7.3 months (95% CI, 4.6–10.0) among 24 patients evaluated as partial response (PR). The most common treatment‐related adverse events (TRAEs) included anemia (71.1%), anorexia (57.9%), asthenia (52.6%), hypoesthesia (52.6%), bone marrow suppression (47.4%), alopecia (47.4%), nausea (44.7%), proteinuria (36.8%), vomiting (34.2%), and hypoalbuminemia (31.6%). No patient experienced TRAEs of Grade ≥3. One patient had an immune‐related adverse event (irAE) of rash related to toripalimab.ConclusionsBoth as monotherapy and in combination with PD‐1 inhibitors, RC48‐ADC exhibits promising effectiveness and manageable safety profile for mUC patients in real‐world settings.
Psychotherapy students' experiences of supervisee‐centred supervision based on deliberate practice, feedback‐informed treatment and self‐compassion
Authors: Axelsson Susanne , Kihlberg Sara , Davis Paul , Nyström Markus B. T. 
Published: November 2023

AbstractObjectiveThere are few methods that focus on therapists' experiences of supervision. To facilitate the development of psychologist students, a supervisee‐centred supervision, based on deliberate practice, feedback informed treatment and self‐compassion, was introduced.MethodsThis study examines six supervisees’ experiences of a supervisee‐centred supervision. A semi‐ structured interview was used for the collection of the data, which identified two main themes: Learning and Development and five associated sub‐themes: structure and purposesfulness, prerequisites, experience‐based learning, therapeutic skills and personal development.ConclusionThe experience‐ and feedback‐based approach was perceived as efficient, structured and goal oriented. This created high‐focused activity and participation, a strong group dynamic and a good alliance with the supervisors, providing a good climate for learning and development. Focusing on performance and feedback was perceived as a potential obstacle that could create stress and anxiety.
Management of gingival hyperpigmentation induced by increased ferritin level in aHbS‐β+thalassemia patient using diode laser
Authors: Darkazali Raneem , Hamadah Omar 
Published: November 2023

Key Clinical MessageDiode lasers can be employed for the treatment of gingival hyperpigmentation in HbS‐β+thalassemia patients due to the advantages that lasers provide including good hemostatic effect and less postoperative complications.
Acute soft head syndrome in a teenager with sickle cell anemia: A case report
Authors: Magitta Ng'weina F. , Komanya Francisca B. , Alphonce Baraka O. , Bitesigilwe Mbelwa D. , Sindato Emmanuel M. , Meda John R. 
Published: November 2023

Key Clinical MessageSickle cell disease (SCD) rarely presents with acute soft head syndrome (ASHS) often posing a diagnostic dilemma. Recovery is typically spontaneous, however, in the context of lack of awareness and limited brain imaging it could potentially lead to poor outcome.AbstractASHS is a rare complication of SCD, invariably occurring near puberty with hitherto elusive pathogenic mechanisms. ASHS often resolves spontaneously on conservative management, however, lack of awareness in the context of limited access to brain imaging could pose diagnostic challenges resulting in inappropriate management and untoward outcome. We present a case of a teenager who presented with subtle symptoms for which the diagnosis of sickle cell anemia (SCA) was delayed until he developed ASHS. LTM was a 16 years old boy with a history of recurrent joints pain since the age of 6 years, with a family history of SCA, but had initial negative sickling test. He presented with episodes of multiple joints pain, unprovoked scalp and left orbital swelling, low‐grade fever and mild headache without any evidence for bleeding diathesis. The diagnosis of SCA was confirmed by hemoglobin electrophoresis. Computed tomography (CT) scan of the head revealed subgaleal heamatoma (SGH) and intraorbital haematoma without intracranial hemorrhage (ICH). He was managed conservatively with analgesics and hydration together with antibiotics for associated sepsis with complete resolution of clinical symptoms within 2 weeks. This case represents a rare scenario for a relatively mild SCA phenotype presenting with ASHS whose diagnosis poses an enigma in the resource‐limited contex. It is therefore, prudent to recognize ASHS to avoid judicious interventions which could potentially result in untoward clinical outcome.
H2[Pt(C2O4)2] as a Tailor‐made Halide‐free Precursor for the Preparation of Diesel Oxidation Catalysts: Nanoparticles Formation, Thermal Stability and Catalytic Performance
Authors: Spolaore F. , Hengst C. , Dornhaus F. , Votsmeier M. , Gross S. 
Published: November 2023

AbstractThe aim of this study was to investigate a tailor‐made metal precursor and its chemical properties to tune the properties of supported metal nanoparticles (NPs) and their catalytic performance when used as Diesel Oxidation Catalyst (DOC). The formation of extremely small Pt NPs from a new halide‐free Pt complex was investigated, namely bis(oxalato)platinate, H2[Pt(C2O4)2]. The size evolution of the supported NPs, from the formation upon the Pt precursor decomposition on γ‐alumina to the sintering of the NPs at high temperatures, was followed by thermogravimetric analysis coupled with mass spectrometry (TG‐MS) and differential scanning calorimetry (DSC), transmission electron microscopy (TEM) and diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. A correlation between the NPs’ size of the catalyst and the performance for the CO, C3H6, C3H8 and NO oxidation reactions pointed out a retained activity during test cycles, showing low sensitivity to the test conditions applied (i. e., temperature and gas composition). The overall catalytic performance was better in the fresh catalysts compared to the reference catalyst prepared from platinum nitrate, Pt(NO3)4. In particular, the different dispersion of the Pt NPs over the support obtained from the two precursors was identified as the reason for the different catalytic performance, retaining small NPs size after the tests cycles.
One‐Pot Synthesis of ZnO‐Activated Eggshell@kaolinite: Sorbents for Phosphate Capture in Water
Authors: Bayode Ajibola A. , Badamasi Hamza , Olusola Johnson Adedeji , Durodola Solomon S. , Akeremale Olaniran K. , Ore Odunayo T. , Helmreich Brigitte , Omorogie Martins O. 
Published: November 2023

AbstractThe availability of colossal amounts of phosphate in water bodies has led to serious environmental challenges all over the world. In this study, a new adsorbent was synthesized using treated kaolinite clay, pulverized eggshells, and ZnCl2. Surface characterizationof these adsorbents showed the availability of functional moieties, morphological variations, pore sizes, particle sizes, etc. Adsorption of phosphate occurs via multiple mechanisms, comprising ligand exchange, complexation, hydrogen bonding, and electrostatic interaction, among others. The effect of pH, showed that maximum adsorption of 93.3 % was achieved at pH 3.0. It was also shown that these cost‐effective adsorbents could be regenerated in six cycles, hence increasing their applicability.
Unraveling the Fundamental Concepts of Superaerophobic/Superhydrophilic Electrocatalysts for Highly Efficient Water Electrolysis: Implications for Future Research
Authors: Shen Jingjun , Zheng Yihao , Lei Wen , Shao Huaiyu 
Published: November 2023

AbstractElectrochemical water splitting is a highly effective method for carbon‐free hydrogen production. While significant efforts have been made to develop efficient and cost‐effective electrocatalysts for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), the optimization of electrode surface properties has been largely overlooked. Inadequate mass diffusion, especially at high bath voltage, hampers the energy transfer efficiency of water electrolysis. To overcome these challenges, precise design of superaerophobic/superhydrophilic electrodes can effectively separate gas bubbles from the catalyst surface and enhance mass transfer, improving overpotential and Faraday efficiency. This article underscores the importance of designing electrocatalysts with well‐designed surface properties to address these challenges. It also discusses characterization techniques for evaluating surface properties and provides examples of applications for superaerophobic/superhydrophilic electrodes in energy storage and conversion systems, electrochemical biosensors, and industrial processes, etc. Overall, optimizing the surface properties of electrocatalysts holds promise for enhancing the efficiency of gas‐involving reactions and energy conversion systems.
Direct Spectroscopic Identification of BN‐Arynes and Subtle Steric Effects on Nitrogen Fixation**
Authors: Gupta Divanshu , Keck Constanze , Tönshoff Christina , Bhagat Virinder , Strobel Raphael , Eder Manuel , Baylère Patrick , Labat Stéphane , Chrostowska Anna , Bettinger Holger F. 
Published: November 2023

Abstract1,2‐Azaborinines are the BN analogues of arynes through exchange of the formal CC triple bond by an isoelectronic BN bond. The BN‐arynes are an underexplored class of reactive intermediates. Dibenzo[c,e][1,2]azaborinine (10,9‐BN‐phenanthryne) 1 was inferred as reactive intermediate by trapping reactions. Here it is shown that 1 can be generated in the gas phase by thermolysis from the pyridine adduct of 9‐azido‐9‐borafluorene by cleavage of the dative bond with pyridine and dinitrogen extrusion. The ionization potential of 1 is 8.2 eV with ionization resulting from the π HOMO. Under cryogenic matrix isolation conditions, 9‐azido‐9‐borafluorene photolysis results in isomerization to the dinitrogen adduct of 1 without involvement of a triplet borylnitrene intermediate. Photochemical nitrogen extrusion from 1 ⋅ N2 is not possible and nitrogen fixation is irreversible under cryogenic conditions. In contrast, 2,4,7,9‐tetra‐tert‐butyldibenzo[c,e][1,2]azaborinine can be photogenerated from the corresponding azidoborole precursor under cryogenic matrix isolation conditions, and nitrogen fixation is precluded due to steric hindrance. The BN stretching vibration at about 1750 cm−1 is much weaker than in typical linear diaryl iminoboranes.
Preparation of a Compound with a SiII−SiIV−SiII Bonding Arrangement
Authors: Kushvaha Saroj Kumar , Kallenbach Paula , Gorantla Sai Manoj N. V. T. , Herbst‐Irmer Regine , Stalke Dietmar , Roesky Herbert W. 
Published: November 2023

AbstractHerein, we report the synthesis of a rare bis‐silylene, 1, in which two SiIIatoms are bridged by a SiIV atom. Compound 1 contains an unusual SiII−SiIV−SiII bonding arrangement with SiII−SiIV bond distances of 2.4212(8) and 2.4157(7) Å. Treatment of 1 with Fe(CO)5 afforded a dinuclear Fe0 complex 2 with two unusually long Si−Si bonds (2.4515(8) and 2.4488(10) Å). We have also carried out a detailed computational study to understand the nature of the Si−Si bonds in these compounds. Natural bond orbital (NBO) and energy decomposition analysis–natural orbital for chemical valence (EDA‐NOCV) analyses reveal that the Si−Si bonds in 1 and 2 are of an electron‐sharing nature.
Isolation of (Aryl)‐(Imino) Phosphide and (Aryl)‐(Phosphaalkene) Amide Complexes of Alkali Metals from Carbene‐Phosphinidenes under Reductive‐Thermal Rearrangements
Authors: Nag Ekta , Francis Maria , Putta Divya , Roy Sudipta 
Published: November 2023

AbstractInvited for the cover of this issue are Sudipta Roy and co‐workers at the Indian Institute of Science Education and Research (IISER) Tirupati. The image depicts the rearrangement of cyclic alkyl(amino) carbene (cAAC)‐supported chloro‐phosphinidenes affording two ligands, of which one was used for the solid‐state isolation of three cyclic alkyl(amino‐boryl) phosphaalkenes and two coinage metal clusters. Read the full text of the article at 10.1002/chem.202302120.
Moral, Verantwortung, Nachhaltigkeit
Authors: Wöhrle D. 
Published: November 2023

ZusammenfassungIm Anthropozän kam es aufgrund der Folgen der Industrialisierung zu immer dramatischeren Veränderungen des Zustands des Planeten Erde. Die globale Wirtschaft und das Verhalten der Menschen führten im begrenzten Erdsystem zu Umweltbelastungen und ‐schäden. Ein Umdenken in vielen Bereichen muss stattfinden, um weitere Folgen zu vermeiden. Wegen der Bedeutung der Chemie auch für die Zukunft ist Ethik als moralisches Wertesystem zu verankern. Hier sind die Wissenschaftler durch ihre Verantwortung bei der Anwendung von Ergebnissen der Wissenschaft gefragt. Weiter ist die Nachhaltigkeit für die Bewahrung der Regenerationsfähigkeit von Ökosystemen und dem schonenden Umgang mit Ressourcen wichtig. Notwendig ist, dass in Schulen und Hochschulen die Ethik in der Chemie im Zusammenhang mit Moral, Verantwortung und Nachhaltigkeit behandelt wird.
Polyhydroxyurethanes from Biobased Monomers and CO2: A Bridge between Sustainable Chemistry and CO2 Utilization†
Authors: Theerathanagorn Tharinee , Kessaratikoon Tanika , Rehman Hafeez Ur , D'Elia Valerio , Crespy Daniel 
Published: November 2023

Comprehensive SummaryPolyhydroxyurethanes (PHUs) have received considerable attention in the last decade as potential alternatives to traditional phosgene‐based polyurethanes (PUs). The development of suitable 5CC (five membered‐ring cyclic carbonate) precursors bearing multiple carbonate moieties (multi‐5CCs) is a key requisite for preparing PHUs by polyaddition reaction with bis‐ or polyamines. Producing sustainable PHUs from CO2‐based five‐membered cyclic carbonates (5CCs) obtained from biobased epoxides is a valuable strategy to bridge CO2 utilization and the upcycling of renewable substrates. In this context, while many multi‐5CC monomers reported in the literature are oil‐based, recent efforts have led to the development of a large variety of multifunctional 5CCs that are produced by the combination of CO2 and renewable resources such as fatty acids and vegetable oils, lignin, terpenes, and sugars. In this work, recent crucial advances (2019—2023) on PHUs prepared from bis‐ and multi‐5CCs produced from CO2 and (partially/potentially) biobased substrates are reviewed with respect to their synthesis, thermal and mechanical properties, and their recent, emerging applications.
Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation
Authors: Feng Yang , Chen Sheng‐Jun , Yuan Bi‐Feng 
Published: November 2023

Comprehensive Summary5‐Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher eukaryotes. It has been well‐established that the demethylation of 5mC occurs through the ten‐eleven translocation (TET)‐mediated oxidation of 5mC followed by thymine DNA glycosylase (TDG)‐initiated base excision repair (BER). Recent findings also have identified an alternative pathway of DNA demethylation. In this pathway, TET enzymes directly oxidize 5mC to form 5‐formylcytosine (5fC) or 5‐carboxylcytosine (5caC). These modified bases can undergo direct deformylation or decarboxylation, respectively. Additionally, DNA demethylation can also occur through the deamination of 5mC and 5hmC, resulting in the production of thymine and 5‐hydroxymethyluracil (5hmU), respectively. Various DNA demethylation pathways possess critical functional implications and roles in biological processes. This Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation, shedding light on the reversible nature of the epigenetic modification of 5mC.