bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation with osocimab in patients with kidney failure undergoing hemodialysis: a randomized phase 2 trial
Authors: Weitz Jeffrey I. , Tankó László B. , Floege Jürgen , Fox Keith A. A. , Bhatt Deepak L. , Thadhani Ravi , Hung James , Pap Ákos F. , Kubitza Dagmar , Winkelmayer Wolfgang C. ,   CONVERT Investigators
Published: February 2024

AbstractIndividuals with kidney failure undergoing hemodialysis are at elevated risk for thromboembolic events. Factor (F) XI, which is in the intrinsic pathway of coagulation, is emerging as an attractive target for new anticoagulants that may be safer than existing agents. Osocimab—an inhibitory FXIa antibody—is a potential treatment option for such patients. We conducted a phase 2b, double-blind, placebo-controlled trial, in which 704 participants (448 male, 256 female) with kidney failure undergoing hemodialysis were randomized to receive lower- or higher-dose osocimab or placebo. In total, 686 participants (436 male, 250 female) received treatment for ≤18 months (planned minimal treatment period of 6 months). The co-primary outcomes were clinically relevant bleeding (a composite of major and clinically relevant nonmajor bleeding) and a composite of the incidence of moderate, severe or serious adverse events. Clinically relevant bleeding occurred in 16/232 (6.9%) and 11/224 (4.9%) participants who received lower- and higher-dose osocimab, respectively, and in 18/230 participants (7.8%) who received a placebo. For the composite adverse event endpoint, incidences were 51%, 47% and 43% in the lower-dose osocimab, higher-dose osocimab and placebo groups, respectively. These results suggest that osocimab is associated with a low risk of bleeding and is generally well tolerated in this population; findings that require confirmation in larger trials. ClinicalTrials.gov identifier, NCT04523220.
Ripple-locked coactivity of stimulus-specific neurons and human associative memory
Authors: Kunz Lukas , Staresina Bernhard P. , Reinacher Peter C. , Brandt Armin , Guth Tim A. , Schulze-Bonhage Andreas , Jacobs Joshua 
Published: February 2024

AbstractAssociative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural basis, we investigated whether associative memory involves temporally correlated spiking of medial temporal lobe (MTL) neurons that exhibit stimulus-specific tuning. Using single-neuron recordings from patients with epilepsy performing an associative object–location memory task, we identified the object-specific and place-specific neurons that represented the separate elements of each memory. When patients encoded and retrieved particular memories, the relevant object-specific and place-specific neurons activated together during hippocampal ripples. This ripple-locked coactivity of stimulus-specific neurons emerged over time as the patients’ associative learning progressed. Between encoding and retrieval, the ripple-locked timing of coactivity shifted, suggesting flexibility in the interaction between MTL neurons and hippocampal ripples according to behavioral demands. Our results are consistent with a cellular account of associative memory, in which hippocampal ripples coordinate the activity of specialized cellular populations to facilitate links between stimuli.
China’s low-carbon policy intensity dataset from national- to prefecture-level over 2007–2022
Authors: Dong Xinyang , Wang Can , Zhang Fang , Zhang Haowen , Xia Chengqi 
Published: February 2024

AbstractLow-carbon policies are essential for facilitating manufacturing industries’ low-carbon transformation and achieving carbon neutrality in China. However, recent studies usually apply proxy variables to quantify policies, while composite indices of policy intensity measured by objectives and instruments focus more on the national level. It is deficient in direct and comprehensive quantification for low-carbon policies. Hence, having extended the meaning of policy intensity, this paper constructs a low-carbon policy intensity index quantified by policy level, objective and instrument via phrase-oriented NLP algorithm and text-based prompt learning. This process is based on the low-carbon policy inventory we built for China’s manufacturing industries containing 7282 national-, provincial- and prefecture-level policies over 2007–2022. Lastly, we organize the dataset in two formats (.dta and .xlsx) for multidiscipline researchers. Apart from the inventory and intensity for each policy, the policy intensity is also aggregated to national-, provincial- and prefecture-level with sub-intensity for four objectives and three instruments. This dataset has potential uses for future studies by merging with macro and micro data related to low-carbon performances.
Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain
Authors: Bedada Fikru B. , Thompson Brian R. , Mikkila Jennifer L. , Chan Sunny S.-K. , Choi Si Ho , Toso Erik A. , Kyba Michael , Metzger Joseph M. 
Published: February 2024

AbstractHuman induced pluripotent stem cells and their differentiation into cardiac myocytes (hiPSC-CMs) provides a unique and valuable platform for studies of cardiac muscle structure–function. This includes studies centered on disease etiology, drug development, and for potential clinical applications in heart regeneration/repair. Ultimately, for these applications to achieve success, a thorough assessment and physiological advancement of the structure and function of hiPSC-CMs is required. HiPSC-CMs are well noted for their immature and sub-physiological cardiac muscle state, and this represents a major hurdle for the field. To address this roadblock, we have developed a hiPSC-CMs (β-MHC dominant) experimental platform focused on directed physiological enhancement of the sarcomere, the functional unit of cardiac muscle. We focus here on the myosin heavy chain (MyHC) protein isoform profile, the molecular motor of the heart, which is essential to cardiac physiological performance. We hypothesized that inducing increased expression of α-MyHC in β-MyHC dominant hiPSC-CMs would enhance contractile performance of hiPSC-CMs. To test this hypothesis, we used gene editing with an inducible α-MyHC expression cassette into isogeneic hiPSC-CMs, and separately by gene transfer, and then investigated the direct effects of increased α-MyHC expression on hiPSC-CMs contractility and relaxation function. Data show improved cardiac functional parameters in hiPSC-CMs induced with α-MyHC. Positive inotropy and relaxation was evident in comparison to β-MyHC dominant isogenic controls both at baseline and during pacing induced stress. This approach should facilitate studies of hiPSC-CMs disease modeling and drug screening, as well as advancing fundamental aspects of cardiac function parameters for the optimization of future cardiac regeneration, repair and re-muscularization applications.
Integration of basement membrane-related genes in a risk signature for prognosis in clear cell renal cell carcinoma
Authors: Xia Bowen , Wang Jingwei , Zhang Dongxu , Hu Xiaopeng 
Published: February 2024

AbstractClear cell renal cell carcinoma (ccRCC) is characterized by high heterogeneity and recurrence rates, posing significant challenges for stratification and treatment. Basement membrane-related genes (BMGs) play a crucial role in tumor initiation and progression. Clinical and transcriptomic data of ccRCC patients were extracted from TCGA and GEO databases. We employed univariate regression and LASSO-Cox stepwise regression analysis to construct a BMscore model based on BMGs expression level. A nomogram combining clinical features and BMscore was constructed to predict individual survival probabilities. Further enrichment analysis and immune-related analysis were conducted to explore the enriched pathways and immune features associated with BMGs. High-risk individuals predicted by BMscore exhibited poorer overall survival, which was consistent with the validation dataset. BMscore was identified as an independent risk factor for ccRCC. Functional analysis revealed that BMGs were related to cell–matrix and tumor-associated signaling pathways. Immune profiling suggests that BMGs play a key role in immune interactions and the tumor microenvironment. BMGs serve as a novel prognostic predictor for ccRCC and play a role in the immune microenvironment and treatment response. Targeting the BM may represent an alternative therapeutic approach for ccRCC.
Stripe noise removal in conductive atomic force microscopy
Authors: Li Mian , Rieck Jan , Noheda Beatriz , Roerdink Jos B. T. M. , Wilkinson Michael H. F. 
Published: February 2024

AbstractConductive atomic force microscopy (c-AFM) can provide simultaneous maps of the topography and electrical current flow through materials with high spatial resolution and it is playing an increasingly important role in the characterization of novel materials that are being investigated for novel memory devices. However, noise in the form of stripe features often appear in c-AFM images, challenging the quantitative analysis of conduction or topographical information. To remove stripe noise without losing interesting information, as many as sixteen destriping methods are investigated in this paper, including three additional models that we propose based on the stripes characteristics, and thirteen state-of-the-art destriping methods. We have also designed a gradient stripe noise model and obtained a ground truth dataset consisting of 800 images, generated by rotating and cropping a clean image, and created a noisy image dataset by adding random intensities of simulated noise to the ground truth dataset. In addition to comparing the results of the stripe noise removal visually, we performed a quantitative image quality comparison using simulated datasets and 100 images with very different strengths of simulated noise. All results show that the Low-Rank Recovery method has the best performance and robustness for removing gradient stripe noise without losing useful information. Furthermore, a detailed performance comparison of Polynomial fitting and Low-Rank Recovery at different levels of real noise is presented.
Creating an atlas of normal tissue for pruning WSI patching through anomaly detection
Authors: Nejat Peyman , Alsaafin Areej , Alabtah Ghazal , Comfere Nneka I. , Mangold Aaron R. , Murphree Dennis H. , Zot Patricija , Yasir Saba , Garcia Joaquin J. , Tizhoosh H. R. 
Published: February 2024

AbstractPatching whole slide images (WSIs) is an important task in computational pathology. While most of them are designed to classify or detect the presence of pathological lesions in a WSI, the confounding role and redundant nature of normal histology are generally overlooked. In this paper, we propose and validate the concept of an “atlas of normal tissue” solely using samples of WSIs obtained from normal biopsies. Such atlases can be employed to eliminate normal fragments of tissue samples and hence increase the representativeness of the remaining patches. We tested our proposed method by establishing a normal atlas using 107 normal skin WSIs and demonstrated how established search engines like Yottixel can be improved. We used 553 WSIs of cutaneous squamous cell carcinoma to demonstrate the advantage. We also validated our method applied to an external dataset of 451 breast WSIs. The number of selected WSI patches was reduced by 30% to 50% after utilizing the proposed normal atlas while maintaining the same indexing and search performance in leave-one-patient-out validation for both datasets. We show that the proposed concept of establishing and using a normal atlas shows promise for unsupervised selection of the most representative patches of the abnormal WSI patches.
Broken edge spin symmetry induces a spin-polarized current in graphene nanoribbon
Authors: Ali Shahjad , Ali Md Ehesan 
Published: February 2024

Abstract
Zigzag graphene nanoribbons (ZGNRs) are known to possess spin moments at the hydrogen-terminated edge carbon atoms; thus, spin-polarized electron transmission is expected, while the current is longitudinally passed through the ZGNRs. However, in pristine ZGNRs, spin-polarized transmission is not observed due to symmetric anti-parallel distributions of the spin densities between the edges. Here, the hypothesis is that any physical or chemical process that breaks such anti-parallel spin symmetry can induce spin-polarized transmission in ZGNRs. In this work, we have established this proof-of-concept by depositing the trimethylenemethane (TMM) radical on 6ZGNRH and investigating the quantum transport properties by employing density functional theory in conjunction with the nonequilibrium Green’s function method. Although TMM has a high magnetic moment (

2

μ

B

), it does not induce magnetization in 6ZGNRH when TMM is physisorbed. However, during the chemisorption of TMM, it forms the

π
−
π

bond with the 6ZGNRH in a particular geometric configuration, where the p

z
orbitals of carbon atoms of TMM have maximum overlap with the p

z
orbitals of carbon atoms of 6ZGNRH. The chemisorption of TMM transfers the spin moment to 6ZGNRH, which breaks the edge spin symmetry of pristine 6ZGNRH. The adsorption of the TMM radical results in transmission dips in the transmission spectra due to interference between localized states of TMM and 6ZGNRH states. This induces spin-polarized transmission with 60% spin-filtering efficiency at zero bias, which can further be enhanced up to 92% by applying a bias voltage of 1.0 V.
Tailoring optoelectronic performance through compositional engineering to optimize trap densities in Cs
x
MA(1−
x)
PbI3 perovskite nanowires
Authors: Han Bin , Hu Yu , Liu Bo , Wang Guanghui , Qiu Qi , Tang Yanren , Ma Shufang , Xu Bingshe , Qiu Bocang , Hsu Hsien-Yi 
Published: February 2024

Abstract
Organic-inorganic methylammonium lead iodide perovskite (MAPbI3) nanowires (NWs) have attracted significant attention in the realm of optoelectronic devices due to their outstanding optoelectronic properties. However, the persistent challenge of high trap densities has been a limiting factor in realizing their full potential in device performance. To address this challenge, we incorporated cesium (Cs) and systematically investigated the impact of Cs concentration on the trap densities and the optoelectronic characteristics of Cs
x
MA(1−x)PbI3 NWs. Our findings unveiled an initial reduction in trap densities as Cs+ content increased, with the lowest point occurring at x = 0.2. However, beyond this threshold, trap densities began to rise, eventually surpassing those observed in pure MAPbI3 at x = 0.4. Furthermore, we fabricated single NW photodetectors to assess how Cs+ content influenced optoelectronic properties. The results indicated that Cs+ incorporation led to enhancements in photocurrent and response speed, withthe optimal performance observed at x = 0.2. Our study provides valuable insights into the role of Cs+ incorporation in tailoring the optoelectronic properties of perovskite NWs.
Tracking electron motion within and outside of Floquet bands from attosecond pulse trains in time-resolved ARPES
Authors: Neufeld Ofer , Hübener Hannes , Giovannini Umberto De , Rubio Angel 
Published: February 2024

Abstract
Floquet engineering has recently emerged as a technique for controlling material properties with light. Floquet phases can be probed with time- and angle-resolved photoelectron spectroscopy (Tr-ARPES), providing direct access to the laser-dressed electronic bands. Applications of Tr-ARPES to date focused on observing the Floquet-Bloch bands themselves, and their build-up and dephasing on sub-laser-cycle timescales. However, momentum and energy resolved sub-laser-cycle dynamics between Floquet bands have not been analyzed. Given that Floquet theory strictly applies in time-periodic conditions, the notion of resolving sub-laser-cycle dynamics between Floquet states seems contradictory—it requires probe pulse durations below a laser cycle that inherently cannot discern the time-periodic nature of the light-matter system. Here we propose to employ attosecond pulse train probes with the same temporal periodicity as the Floquet-dressing pump pulse, allowing both attosecond sub-laser-cycle resolution and a proper projection of Tr-ARPES spectra on the Floquet–Bloch bands. We formulate and employ this approach in ab-initio calculations in light-driven graphene. Our calculations predict significant sub-laser-cycle dynamics occurring within the Floquet phase with the majority of electrons moving within and in-between Floquet bands, and a small portion residing and moving outside of them in what we denote as ‘non-Floquet’ bands. We establish that non-Floquet bands arise from the pump laser envelope that induces non-adiabatic electronic excitations during the pulse turn-on and turn-off. By performing calculations in systems with poly-chromatic pumps we also show that Floquet states are not formed on a sub-laser-cycle level. This work indicates that the Floquet-Bloch states are generally not a complete basis set for sub-laser-cycle dynamics in steady-state phases of matter.
A method of measuring equivalent parameters of quartz crystal resonators
Authors: Wan Yang , Yang Zhuoping , Luan Xinghe , Wu Fengshun 
Published: February 2024

Abstract
Quartz crystal resonators (QCRs) can be described by four parameters in the BVD-equivalent circuit: static capacitance (C
0), motional capacitance (C
1), motional inductance (L
1), and motional resistance (R
1). In this study, we propose a set of formulae through theoretical deduction to evaluate these four parameters using the impedances of QCRs at different frequencies. Using this method, engineers can evaluate the four parameters without theoretical errors in only one frequency sweep. The method has been verified by LTspice simulation. In the simulation, the average error was 0.35%, which demonstrated its correctness. Meanwhile, in practical measurements, compared to the parameters reported by 250B, the parameters calculated using this method demonstrated better fitting ability. Moreover, the calculation process was simple. Therefore, the measuring procedures and apparatus can be simplified using this method.
Spatial coherence research and passive speckle suppression for edge-emitting broad-area semiconductor lasers
Authors: Chen Ao , Zhang WeiQiao , Zhou XuYan , Liu Jing , Zheng WanHua 
Published: February 2024

Abstract
The spatial coherence of filaments in edge-emitting broad-area semiconductor lasers (BALs) is studied based on speckle theory, and a passive speckle suppression method for BALs is demonstrated. A fly-eye lens is used to integrate the filaments and homogenize the laser beam. The speckle contrast is consistent with theoretical calculation, which proves the spatial incoherence of filaments. A light pipe is used to introduce an optical path difference between light with different incident angles, enabling more incoherent beamlets. These beamlets are then combined at different illuminating angles by a double-sided fly-eye lens and focusing lens. As a result, the subjective speckle contrast is reduced from 95.94% to 19.13% at 1.2 A while maintaining a high luminous efficiency of 77.8%. This work provides important design principles for laser display systems.
Quantifying water-use efficiency in plant canopies with varying leaf angle and density distribution
Authors: Ponce de León María A , Bailey Brian N 
Published: February 2024

Abstract

Background and Aims
Variation in architectural traits related to the spatial and angular distribution of leaf area can have considerable impacts on canopy-scale fluxes contributing to water-use efficiency (WUE). These architectural traits are frequent targets for crop improvement and for improving the understanding and predictions of net ecosystem carbon and water fluxes.

Methods
A three-dimensional, leaf-resolving model along with a range of virtually generated hypothetical canopies were used to quantify interactions between canopy structure and WUE by examining its response to variation of leaf inclination independent of leaf azimuth, canopy heterogeneity, vegetation density and physiological parameters.

Key Results
Overall, increasing leaf area index (LAI), increasing the daily-averaged fraction of leaf area projected in the sun direction (Gavg) via the leaf inclination or azimuth distribution and increasing homogeneity had a similar effect on canopy-scale daily fluxes contributing to WUE. Increasing any of these parameters tended to increase daily light interception, increase daily net photosynthesis at low LAI and decrease it at high LAI, increase daily transpiration and decrease WUE. Isolated spherical crowns could decrease photosynthesis by ~60 % but increase daily WUE ≤130 % relative to a homogeneous canopy with equivalent leaf area density. There was no observed optimum in daily canopy WUE as LAI, leaf angle distribution or heterogeneity was varied. However, when the canopy was dense, a more vertical leaf angle distribution could increase both photosynthesis and WUE simultaneously.

Conclusions
Variation in leaf angle and density distributions can have a substantial impact on canopy-level carbon and water fluxes, with potential trade-offs between the two. These traits might therefore be viable target traits for increasing or maintaining crop productivity while using less water, and for improvement of simplified models. Increasing canopy density or decreasing canopy heterogeneity increases the impact of leaf angle on WUE and its dependent processes.
Management of ventricular tachycardias: insights on centre settings, procedural workflow, endpoints, and implementation of guidelines—results from an EHRA survey
Authors: Sultan Arian , Futyma Piotr , Metzner Andreas , Anic Ante , Richter Sergio , Roten Laurent , Badertscher Patrick , Conte Giulio , Chun Julian K R 
Published: February 2024

Abstract
Ventricular tachycardia (VT), and its occurrence, is still one of the main reasons for sudden cardiac death and, therefore, for increased mortality and morbidity foremost in patients with structural heart [Kahle A-K, Jungen C, Alken F-A, Scherschel K, Willems S, Pürerfellner H et al. Management of ventricular tachycardia in patients with ischaemic cardiomyopathy: contemporary armamentarium. Europace 2022;24:538–51]. Catheter ablation has become a safe and effective treatment option in patients with recurrent VT [Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Heart Rhythm 2020;17:e2–154]. Previous and current guidelines provide guidance on indication for VT ablation and risk assessment and evaluation of underlying disease. However, no uniform recommendation is provided regarding procedural strategies, timing of ablation, and centre setting. Therefore, these specifics seem to differ largely, and recent data are sparse. This physician-based European Heart Rhythm Association survey aims to deliver insights on not only infrastructural settings but also procedural specifics, applied technologies, ablation strategies, and procedural endpoints. Therefore, these findings might deliver a real-world scenario of VT management and potentially are of guidance for other centres.