bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting the containerized freight index with AIS data: A novel information combination method based on gray incidence analysis
Authors: Chen Yanhui , Feng Ailing , Chen Shun , Mi Jackson Jinhong 
Published: January 2024

AbstractThis paper uses the container shipping capacities of 11 major trade lanes, obtained from automatic identification system (AIS), to construct a common factor based on gray incidence analysis (GIA) in the aim of improving the predictability of containerized freight index. Our results show that the common factor generated by GIA consistently exhibits better out‐of‐sample prediction performances than principal component analysis (PCA) and least absolute shrinkage and selection operator (LASSO), meaning that GIA can extract more useful information for forecasting freight index. Our main findings are first, GIA can evaluate the similarity between the predictors and the predicted value. Unlike popular information combination method PCA, which cannot extract the relevant information from the predictors, GIA can extract the most relevant information of the predictors to the predicted value. Second, different from LASSO, which drops some information, GIA maintains the most information, because the container shipping capacities of different lanes all impact the freight index. Third, AIS data do provide information increments for freight rate forecasting. This research explores a new field application of gray relational analysis in information combination and presents one application of GIA in big data processing. This research shows the usefulness of AIS information in predicting freight index. Additionally, this research enlightens the prediction of freight rate based on big data from AIS.
Agricultural market information: How much and who is willing to pay for it?
Authors: Zhllima Edvin , Xhoxhi Orjon , Skreli Engjell , Imami Drini 
Published: January 2024

AbstractAccess to an agricultural market information system (AMIS) is essential to reduce farmers' risk from market speculation related to information asymmetry. However, AMIS's sustainability depends on the users' needs and willingness to pay (WTP) for market information. This paper explores the WTP for market information among market‐oriented farmers, as well as its determinants. Data were collected through a structured survey with 479 farmers. A contingent dichotomous choice dual boundary estimation is used to measure WTP and a logistic regression is used to ascertain the main determinants of the stated WTP. Experienced losses, access to market information, use of non‐virtual means of information, and degree of farm specialization are the main determinants of the WTP. These findings are useful for establishing a feasible AMIS, and designing its services according to the characteristics, needs, capacities and preferences of the identified potential users.
Dimension‐based quantification of aging‐associated cerebral microvasculature determined by optical coherence tomography and two‐photon microscopy
Authors: Yan Feng , Alhajeri Zaid A. , Nyul‐Toth Adam , Wang Chen , Zhang Qinghao , Mercyshalinie Ebenezer Raj Selvaraj , Delfavero Jordan , Ahire Chetan , Mutembei Bornface M. , Tarantini Stefano , Csiszar Anna , Tang Qinggong 
Published: January 2024

AbstractCerebral microvascular health is a key biomarker for the study of natural aging and associated neurological diseases. Our aim is to quantify aging‐associated change of microvasculature at diverse dimensions in mice brain. We used optical coherence tomography (OCT) and two‐photon microscopy (TPM) to obtain nonaged and aged C57BL/6J mice cerebral microvascular images in vivo. Our results indicated that artery & vein, arteriole & venule, and capillary from nonaged and aged mice showed significant differences in density, diameter, complexity, perimeter, and tortuosity. OCT angiography and TPM provided the comprehensive quantification for arteriole and venule via compensating the limitation of each modality alone. We further demonstrated that arteriole and venule at specific dimensions exhibited negative correlations in most quantification analyses between nonaged and aged mice, which indicated that TPM and OCT were able to offer complementary vascular information to study the change of cerebral blood vessels in aging.
Rapid and robust bacterial species identification using hyperspectral microscopy and gram staining techniques
Authors: Zhou Yanzhong , Li Jieming , Li Zhen , Yin Hao , Zhu Siqi , Chen Zhenqiang 
Published: January 2024

AbstractGram staining can classify bacterial species into two large groups based on cell wall differences. Our study revealed that within the same gram group (gram‐positive or gram‐negative), subtle cell wall variations can alter staining outcomes, with the peptidoglycan layer and lipid content significantly influencing this effect. Thus, bacteria within the same group can also be differentiated by their spectra. Using hyperspectral microscopy, we identified six species of intestinal bacteria with 98.1% accuracy. Our study also demonstrated that selecting the right spectral band and background calibration can enhance the model's robustness and facilitate precise identification of varying sample batches. This method is suitable for analyzing bacterial community pathologies.
A molar view of goal direction and habit
Authors: Baum William M. 
Published: January 2024

AbstractWhen we treat behavior within an evolutionary framework and as temporally extended flow, two fundamental questions arise: (a) What is an organism? and (b) What is behavior? An organism is a process that stays intact by constantly exchanging energy with the environment. It takes in resources and puts out waste. The behavior of an organism consists of those process parts of the organism process that make up the exchange. These activities serve the function of reproducing, which generally depends on surviving. Surviving and reproducing depend on responding to phylogenetically important events (PIEs). A PIE induces activities that enhance or mitigate the PIE. Organisms respond not only to a PIE but also to events that covary with the PIE. Both activities and environmental features may covary with a PIE. When either type of covariance is introduced to an organism, behavior adapts over time. The early stages of adaptation constitute what researchers call “goal direction,” and the later stages constitute what researchers call “habit.” Behavior and environment constitute a dynamic system, and manipulations of the covariances and environmental features of the system allow many experimental interventions. This molar approach allows experiments on goal direction and habit to be understood without appeal to everyday mentalistic terms.
Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise
Authors: Giloteaux Ludovic , Glass Katherine A. , Germain Arnaud , Franconi Carl J. , Zhang Sheng , Hanson Maureen R. 
Published: January 2024

AbstractIn healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue and reduces the risk of chronic diseases. Although exercise is suggested as a lifestyle intervention to manage various chronic illnesses, it negatively affects people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), who suffer from exercise intolerance. We hypothesized that altered extracellular vesicle (EV) signalling in ME/CFS patients after an exercise challenge may contribute to their prolonged and exacerbated negative response to exertion (post‐exertional malaise). EVs were isolated by size exclusion chromatography from the plasma of 18 female ME/CFS patients and 17 age‐ and BMI‐matched female sedentary controls at three time points: before, 15 min, and 24 h after a maximal cardiopulmonary exercise test. EVs were characterized using nanoparticle tracking analysis and their protein cargo was quantified using Tandem Mass Tag‐based (TMT) proteomics. The results show that exercise affects the EV proteome in ME/CFS patients differently than in healthy individuals and that changes in EV proteins after exercise are strongly correlated with symptom severity in ME/CFS. Differentially abundant proteins in ME/CFS patients versus controls were involved in many pathways and systems, including coagulation processes, muscle contraction (both smooth and skeletal muscle), cytoskeletal proteins, the immune system and brain signalling.
Sex differences in sleep architecture in a mouse model of Huntington's disease
Authors: Chiem Emily , Zhao Kevin , Stark Gemma , Ghiani Cristina A. , Colwell Christopher S. , Paul Ketema N. 
Published: January 2024

AbstractSleep and circadian rhythm disturbances are common features of Huntington's disease (HD). HD is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies as well as preclinical work indicate there may be sex differences in disease presentation and progression. Since sex differences in HD could provide important insights to understand cellular and molecular mechanism(s), we used the bacterial artificial chromosome transgenic mouse model of HD (BACHD) to examine whether sex differences in sleep/wake cycles are detectable in an animal model of the disease. Electroencephalography/electromyography (EEG/EMG) was used to measure sleep/wake states and polysomnographic patterns in young adult (12‐week‐old) male and female wild‐type and BACHD mice. Our findings show that male, but not female, BACHD mice exhibited increased variation in phases of the rhythms as compared to age‐ and sex‐matched wild‐types. For both rapid‐eye movement (REM) and non‐rapid eye movement (NREM) sleep, genotypic and sex differences were detected. In particular, the BACHD males spent less time in NREM sleep and exhibited a more fragmented sleep than the other groups. Finally, in response to 6 h of sleep deprivation, both genotypes and sexes displayed the predicted homeostatic responses to sleep loss. These findings suggest that females are relatively protected early in disease progression in this HD model.
Short‐term outcomes of laparoscopic and robotic distal gastrectomy for gastric cancer: Real‐world evidence from a large‐scale inpatient database in Japan
Authors: Hondo Nao , Yamamoto Yuta , Nakabe Takayo , Otsubo Tetsuya , Kitazawa Masato , Nakamura Satoshi , Koyama Makoto , Miyazaki Satoru , Kataoka Masahiro , Soejima Yuji 
Published: January 2024

AbstractBackground and ObjectivesRobotic distal gastrectomy (RDG) has been widely performed throughout Japan since it became insured in 2018. This study aimed to evaluate the short‐term outcomes of RDG and laparoscopic distal gastrectomy (LDG) for gastric cancer using real‐world data.MethodsA total of 4161 patients who underwent LDG (n = 3173) or RDG (n = 988) for gastric cancer between April 2018 and October 2022 were identified through the Japanese Diagnosis Procedure Combination Database, which covers 42 national university hospitals. The primary outcome was postoperative in‐hospital mortality rate. The secondary outcomes were postoperative complication rates, time to diet resumption, and postoperative length of stay (LOS).ResultsIn‐hospital mortality and postoperative complication rates in the RDG group were comparable with those in the LDG group (0.1% vs. 0.0%, p = 1.000, and 8.7% vs. 8.2%, p = 0.693, respectively). RDG was associated with a longer duration of anesthesia (325 vs. 262 min, p < 0.001), similar time to diet resumption (3 vs. 3 days, p < 0.001), and shorter postoperative LOS (10 vs. 11 days, p < 0.001) compared with LDG.ConclusionsRDG was performed safely and provided shorter postoperative LOS, since it became covered by insurance in Japan.
Decreased posterior tibial slope is a risk factor for primary posterior cruciate ligament rupture and posterior cruciate ligament reconstruction failure: A systematic review
Authors: Nedaie Soroush , Vivekanantha Prushoth , O'Hara Kaylin , Slawaska‐Eng David , Cohen Dan , Abouali Jihad , Hoshino Yuichi , Nagai Kanto , Johnson Jansen , de SA Darren 
Published: January 2024

AbstractPurposeTo determine bony knee morphological factors associated with primary posterior cruciate ligament (PCL) rupture or PCL graft failure after PCL reconstruction.MethodsThree databases, namely MEDLINE, PubMed and EMBASE, were searched on 30th May 2023. The authors adhered to the PRISMA and R‐AMSTAR guidelines as well as the Cochrane Handbook for Systematic Reviews of Interventions. Data such as receiver operating characteristic curve parameters, as well as p‐values for comparisons of values between patients with PCL pathology and control patients, were recorded.ResultsNine studies comprising 1054 patients were included. Four studies reported that patients with PCL injury had flatter medial posterior tibial slopes (MTS) than controls, with mean values of 4.3 (range: 3.0–7.0) and 6.5 (range: 5.0–9.2) degrees, respectively. Two studies reported an MTS cutoff value ranging below 3.90–3.93° being a significant risk factor for primary PCL rupture or PCL graft failure. Two studies reported that shallow medial tibial depths were associated with primary PCL rupture, with mean values of 2.1 (range: 2.0–2.2) and 2.6 (range: 2.4–2.7) mm in PCL injury and control groups, respectively. Stenotic intercondylar notches and femoral condylar width were not consistently associated with PCL injuries.ConclusionDecreased MTS is associated with primary PCL rupture and graft failure after PCL reconstruction with values below 3.93° being considered as a significant risk factor. Less common risk factors include shallow medial tibial depth, while femoral condylar width and parameters with regards to the intercondylar notch, such as notch width, notch width index and intercondylar notch volume, demonstrated conflicting associations with primary or secondary PCL injuries.Level of EvidenceLevel III.
Intercondylar notch width and osteophyte width impact meniscal healing and clinical outcomes following transtibial pullout repair of medial meniscus posterior root tears
Authors: Hiranaka Takaaki , Furumatsu Takayuki , Yokoyama Yusuke , Higashihara Naohiro , Tamura Masanori , Kawada Koki , Xue Haowei , Ozaki Toshifumi 
Published: January 2024

AbstractPurposeThis retrospective study aimed to investigate the relationship between intercondylar notch width (ICNW), osteophyte width (OW), and the healing of medial meniscus posterior root tears (MMPRTs) following arthroscopic pullout repair.MethodsThe study included 155 patients diagnosed with MMPRTs who underwent transtibial pullout repair. Meniscal healing status was evaluated on second‐look arthroscopy using a previously reported meniscus healing score. Patients were divided into two groups based on this score: the high healing score (group HH, healing score ≥ 8 points) and suboptimal healing score (group SO, healing score ≤ 6 points) groups. Computed tomography scans were performed on patients 1 week postsurgery. ICNW and OW widths were measured and relatively evaluated based on their ratio to the intercondylar distance (ICD), represented as the ICNW/ICD ratio (%) and OW/ICD ratio (%), respectively. Patient‐reported outcomes were assessed preoperatively and on second‐look arthroscopy using the Knee injury and Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS).ResultsThere were no significant demographic differences between the SO and HH group (n = 35 and 120 patients, respectively). Regarding radiographic measurements, significant differences were observed in the ICNW/ICD ratio (group SO, 24.2%; group HH, 25.2%; p = 0.024), OW (group SO, 2.6 mm; group HH, 2.0 mm; p < 0.001), and OW/ICD ratio (group SO, 3.5%; group HH, 2.7%; p < 0.001). Both groups had similar preoperative clinical scores, but postoperative clinical scores, including KOOS‐activities of daily living (group SO, 83.4; group HH, 88.7; p = 0.035) and VAS (group SO, 19.1; group HH, 11.3; p = 0.005), were significantly better in group HH.ConclusionThe study suggests that ICNW and OW may play a crucial role in MMPRT healing following arthroscopic pullout repair, as evidenced by the worse clinical outcomes associated with a narrower ICNW and wider OW. These findings highlight the potential significance of ICNW and OW assessments when evaluating meniscal repair indications.Level of EvidenceLevel III.
Insights into the Excited State Dynamics of Donor–Acceptor Organic Photosensitizer for Precise Deep‐Brain Two‐Photon Photodynamic Therapy
Authors: Zhao Hui , He Mubin , He Tingchao , Wu Zizi , Pan Yonghui , Gao Jia , Miao Xiaofei , Li Junzi , Ma Huili , Huang Wei , Hu Wenbo , Fan Quli 
Published: January 2024

AbstractOrganic photosensitizer with both large two‐photon absorption (σ) and efficient intersystem crossing (ISC) offers incomparable advantages in precise two‐photon photodynamic therapy. However, the current design strategy cannot achieve efficient ISC without compromising σ. Here, very efficient ISC and ultrahigh σ in organic photosensitizer (PFBT) for precise cerebrovascular two‐photon photodynamic therapy is simultaneously achieved. A hybridized local and charge‐transfer (1HLCT) excited state in PFBT, formed by incorporating benzothiadiazole into a typical polyfluorene (PF), is the key to initiating efficient ISC while bringing substantial σ enhancement (25 000 GM vs 10 000 GM) compared to PF. Mechanism studies identify that 1HLCT produces large spin‐orbit coupling and tiny singlet‐triplet energy gaps, together generating efficient ISC. These properties afford PFBT nanophotosensitizer a ≈2000‐fold increase in two‐photon photodynamic therapy efficiency than clinically‐used Photofrin, enabling in vivo deep‐brain cerebrovascular imaging and closure with unprecedented precision.
ITGA7 loss drives the differentiation of adipose‐derived mesenchymal stem cells to cancer‐associated fibroblasts
Authors: Liu Xiaoli , Gao Rui , Wu Qiulei , Li Guoqing , Xu Xiaohan , Li Wenhan , Liu Pan , Wang Xiaoman , Cai Jing , Li Min , Wang Zehua 
Published: January 2024

AbstractCancer‐associated fibroblasts (CAFs) represent a major cellular component of the tumor (pre‐)metastatic niche and play an essential role in omental dissemination of ovarian cancer. The omentum is rich in adipose, and adipose‐derived mesenchymal stem cells (ADSCs) have been identified as a source of CAFs. However, the molecular events driving the phenotype shift of ADSCs remain largely unexplored. In this research, we focus on integrins, transmembrane receptors that have been widely involved in cellular plasticity. We found that integrin α7 (ITGA7) was the only member of the integrin family that positively correlated with both overall survival and progression‐free survival in ovarian cancer through GEPIA2. The immunohistochemistry signal of ITGA7 was apparent in the tumor stroma, and a lower omental ITGA7 level was associated with metastasis. Primary ADSCs were isolated from the omentum of patients with ovarian cancer and identified by cellular morphology, biomarkers, and multilineage differentiation. The conditional medium of ovarian cancer cells induced ITGA7 expression decrease and phenotypic changes in ADSCs. Downregulation of ITGA7 in primary omental ADSCs led to decrease in stemness properties and emerge of characteristic morphology and biomarkers of CAFs. Moreover, the conditioned medium of ADSCs with ITGA7 depletion exhibited enhanced abilities to improve the migration and invasion of ovarian cancer cells in vitro. Overall, these findings indicate that loss of ITGA7 may induce the differentiation of ADSCs to CAFs that contribute to a tumor‐supportive niche.
Digital technology adoption strategies for a contract farming supply chain under CVaR criterion
Authors: Liao Changhua , Lu Qihui 
Published: January 2024

AbstractThis study considers a contract farming supply chain consisting of a platform and a risk‐averse farmer with yield uncertainty. It establishes game theory models with and without digital technology under CVaR criterion and analyzes three digital cooperation mechanisms. We find that when the wholesale price is moderate, both parties will choose a cost‐sharing contract; when the wholesale price is high, both parties will choose to let the farmer bear the cost of digital investment; when the farmer uses digital technology to grow agricultural products, the platform should not provide the farmer with a low wholesale price, especially for the farmer with low risk aversion.
Subjective Cognitive Complaints in Parkinson's Disease: A Systematic Review and Meta‐Analysis
Authors: Siciliano Mattia , Tessitore Alessandro , Morgante Francesca , Goldman Jennifer G. , Ricciardi Lucia 
Published: January 2024

AbstractBackgroundSubjective cognitive complaints (SCCs) in Parkinson's disease (PD) are reported frequently, but their prevalence and association with changes on objective testing are not fully known.ObjectiveWe aimed to determine the prevalence, clinical correlates, and predictive value of SCCs in PD.MethodsWe conducted a systematic review and meta‐analysis. From 204 abstracts, we selected 31 studies (n = 3441 patients), and from these, identified the prevalence, clinical features, associations with neuropsychiatric symptoms, and predictive values of SCCs in PD.ResultsThe meta‐analysis showed an SCC prevalence of 36%. This prevalence, however, was significantly moderated by study heterogeneity regarding female sex, disease severity, levodopa equivalent daily dosage, exclusion from the overall sample of patients with objective cognitive impairment, and measurement instrument. SCC prevalence did not differ between de novo and treated PD patients. SCCs were weakly and negligibly associated with cognitive changes on objective testing in cross‐sectional studies. However, in cognitively healthy patients, SCCs had a risk ratio of 2.71 for later cognitive decline over a mean follow‐up of 3.16 years. Moreover, SCCs were moderately related to co‐occurring symptoms of depression, anxiety, or apathy and were more strongly related to these neuropsychiatric symptoms than objective cognitive functioning.ConclusionOur analyses suggest that SCCs in patients with and without objective cognitive impairment are frequent, occurring in more than one third of PD patients. Establishing uniform measurement instruments for identifying PD‐related SCCs is critical to understand their implications. Even in cases lacking evidence of objective cognitive impairment and where SCCs might reflect underlying neuropsychiatric symptoms, the possibility of later cognitive deterioration should not be excluded. Therefore, SCCs in PD patients warrant close monitoring for opportunities for targeted and effective interventions. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.