bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methylation of RARß is a New Clinical Biomarker for Treatment in Higher-grade Gliomas
Authors: Toprak Cigdem , Atli Emine Ikbal , Kalkan Rasime 
Published: September 2023

ABSTRACT

Background:
The dysregulation of various pathways and cellular processes contributes to the carcinogenic transition from low-grade gliomas to high-grade gliomas. The altered tumor microenvironment, altered epigenetic state, and high mutation heterogeneity are critical factors in glial tumors. The morphogen retinoic acid (RA) controls the homeostasis, regeneration, and development of the brain. RA receptor (RAR) gene methylation has been shown in different types of glial tumors.

Aims and Objectives:
This study assessed the RARß gene as a potential therapeutic target in gliomas.

Materials and Methods:
Using in silico methods, potential drugs targeting the RARß gene were compared based on temozolomide’s effectiveness in treating gliomas.

Results and Conclusion:
Computational techniques can be used to identify drug-mediated pathways. This in silico study holds promise for RARB and RARB-targeted treatment strategies in gliomas.
Can Electrodiagnostic Tests be Omitted from Surgical Decision-making for Typical Carpal Tunnel Syndrome? – A Randomized Controlled Trial
Authors: Sucu Hasan Kamil , Gökmen Aytül , Eşmeli Figen , Özdemirkiran Tolga 
Published: September 2023

ABSTRACT

Background:
Although carpal tunnel syndrome (CTS) is common and frequently seen in daily practice, diagnostic criteria remain the subject of debate. Some authors consider electrodiagnostic tests as essential, whereas others view them as an unnecessary luxury.

Objective:
The objective is to investigate whether electrodiagnostic tests are necessary for surgical decision-making for typical CTS.

Materials and Methods:
The study was planned as a randomized controlled trial. After determining normative values for the population of the geographic region, 101 consecutive cases of typical CTS of the hand (suffering palmar dysesthesia that waking from sleep at night) were enrolled in the study. Hands were randomized into two groups using simple randomization. The first group comprised patients whose surgical candidacy was evaluated without electrodiagnostic tests, and the second group comprised patients whose surgery decisions were based on the results of electrodiagnostic testing. The patients were evaluated at 1, 3, and 12 months postoperatively.

Results:
Sixty-one hands were randomized to the first group and 40 hands were randomized to the second group. Four cases in the second group received medical treatment because their electrodiagnostic test results were within the normal limits, despite the presence of typical CTS symptoms. There were no differences in favor of the second group regarding any evaluation criteria during the entire follow-up period; however, the first group reported significantly more positive outcomes regarding awakening at the 3-month follow-up and regarding satisfaction at the 1-month follow-up.

Conclusion:
Additional electrodiagnostic tests may not be mandatory to clinically identify classical CTS or make surgical decisions in these cases. However, many cases may be caused by entrapment of the median nerve in the carpal tunnel, but they may lack typical CTS symptoms, such as waking from night-time sleep. In such cases, properly applied electrodiagnostic tests may be of immense help.
The Degree of Commitment of School Principals to Professional Ethics from the Point of View of Secondary School Teachers and Students in the Directorate of Education of Bani Obaid District in Irbid Governorate
Authors: Al-Smadi Lina Abdul Karim , Al-Hiyari Hassan Ahmed 
Published: September 2023

The study aimed to identify the degree of commitment of school principals to the ethics of the profession from the point of view of secondary school teachers and students in the Directorate of Education of the Bani Obaid District in Irbid Governorate. The study was based on the descriptive survey methodology. Two questionnaires were built to measure the degree of commitment of secondary school principals to professional ethics. The studsample consisted of (49) teachers and (379) female students. The results showed that the degree of commitment of school principals to the ethics of the profession from the teachers point of view was high. The degree of commitment of school principals to the ethics of the profession from the students ’point of view was high. The results revealed that there were statistically significant differences in the degree of commitment of school principals to the ethics of the profession from the point of view of (female and male students), in favor of female teachers.
Rapid ascent: to the 75th anniversary of the artist Zinaida Kurchatova (1948–1983)
Authors: Габышева А.Л. 
Published: September 2023

Статья посвящена творчеству якутского живописца Зинаиды Курчатовой. Цель работы — изучение творчества, выявление особенностей пластического и образного языка художника, работавшего в таких жанрах, как портрет, пейзаж, тематическая картина. С помощью искусствоведческого анализа были установлены композиционные и колористические приемы, трактовка образов автором. Особое внимание уделено пейзажу: колоритный, лаконичный, наполненный эмоциональной глубиной, лирико-эпичным содержанием, он повествует о красоте северной земли и открывает мировидение автора. Обзор выполнен на основе монографической коллекции З.К. Курчатовой, хранящейся в собрании Национального художественного музея Республики Саха (Якутия). Данная статья приоткрывает практически забытую страницу о творчестве члена Регионального отделения Союза художников Якутии, Союза художников России Зинаиды Курчатовой. Работа впервые публикует и вводит ее наследие в научный оборот. Материал актуален для осмысления творчества живописца и для представления более полной панорамы якутского изобразительного искусства второй половины ХХ века.
The article discusses the work of Yakut painter Zinaida Kurchatova. There was no specific focus on studying her legacy in art criticism. The goal of this article is to study the painter's works, to identify the features of her plastic and figurative language considering all the different genres she worked in, such as portrait, landscape, and themed based painting. The study was carried out in accordance with art review principles, which helped to identify compositional and coloristic techniques of the author, as well as her interpretation of images. Particular attention was paid to landscapes. Colorful, concise, full of emotional depth and lyrical-epic content, they recount the beauty of the Northern Land and open up the author's worldview. The study was based on the monographic collection of Zinaida Kurchatova, stored in the collections of the National Arts Museum of the Sakha Republic (Yakutia). This article reveals an almost forgotten page in the creative work member of the Artists Union of Yakutia, Regional Branch of the Union of Artists of Russia, of Zinaida Kurchatova. This is the first work to publish and introduce her legacy into scholarly discourse. The article is relevant for understanding the painter's work and presenting a more complete picture of Yakut fine arts of the second half of the 20th century.
13th Regional art exhibition “Far East”: numbers, facts, conclusions
Authors: Левданская Н.А. 
Published: September 2023

Снижение качества региональных выставок последних лет не раз отмечалось исследователями, занимающимися современным отечественным искусством, и самими художниками. С помощью эмпирического количественного метода автором проведен анализ ротации художников Дальнего Востока, принимавших участие в XII и XIII Региональных выставках «Дальний Восток», выявлены видовые предпочтения в искусстве мастеров разных территорий региона. Методы наблюдения, сравнения, анализа экспозиции, каталогов зональных/региональных экспозиций разных лет позволили сделать выводы о некоторых причинах организационного порядка, ведущих в конечном счете к снижению качества проведения выставок, являющихся на протяжении около шестидесяти лет основным критерием состояния изобразительного искусства в регионах страны.
Researchers involved in contemporary Russian art and artists themselves have repeatedly noted the decline in the quality of interregional exhibitions in recent years. The author of the article, using an empirical quantitative method, analysed the rotation of artists of the Far East who took part in the 12th and 13th Regional exhibitions “Far East”, and identified the specific preferences in the art of masters from different territories. Methods of observation, comparison, analysis of exhibitions, catalogs of zonal/regional exhibitions of different years allowed the author to draw conclusions about some of the reasons for the organizational order, ultimately leading to a decrease in the quality of exhibitions, which for about sixty years have been the main criterion for the state of fine art in the regions of the country.
Strategi Komunikasi Pemasaran Membangun Minat Pengunjung Synchronize Fest 2023
Authors: Sinaga Stevent Yulius , Nindi Iren Ayu 
Published: September 2023

Studi "Strategi Komunikasi Pemasaran Membangun Minat Pengunjung Synchronize Fest 2023" diteliti. Dalam kasus ini, peneliti menemukan masalah di mana penyelenggara mengubah cara mereka berinteraksi dengan audiens karena festival besar dalam industri hiburan sangat bersaing dan berdampak pada pandemi global. Penyelenggaraan festival menghadapi sejumlah masalah. Ini termasuk kekhawatiran tentang kesehatan pengunjung, persaingan dengan festival lain, dan perubahan kebiasaan konsumsi hiburan. Oleh karena itu, rencana harus mencakup komunikasi kesehatan yang ketat, penekanan pada aspek festival unik , penggunaan media sosial dan teknologi, dan kolaborasi dengan influencer untuk menarik pengunjung. Metode ini dapat membuat Synchronize Fest 2023 menjadi pengalaman yang tidak dapat terlupakan bagi semua oranghadir. Metode penelitian ini mengadopsi pendekatan deskriptif kualitatif dengan menggunakan model AISAS. Tujuan penelitian ini yaitu dapat mengetahui strategi komunikasi yang digunakan pada pemasaran untuk membangun minat pengunjung synchronize fest 2023 Hasil dari penelitiannya adalah Strategi komunikasi pemasaran digital yang diterapkan oleh @synchronizefest menggunakan teori AISAS (Attention, Interest, Search, Action, Share) telah terbukti sangat efektif dalam mempromosikan Synchronize Fest 2023 di platform Instagram.
Prognosis Uji Jalan 6 Menit Terhadap Kejadian Kardiovaskular atau Mortalitas Pasien Kardiovaskular
Authors: Angela Devina , Tedjasukmana Deddy 
Published: September 2023

Pendahuluan
Dalam melakukan aktivitas, induvidu membutuhkan metabolisme aerobik submaksimal yang merupakan upaya terpadu dari sistem respirasi, kardiovaskular dan sistem otot rangka yang akan menentukan kapasitas fungsional.1,2 Gangguan pada jantung dan sistem vaskular yang mensuplai oksigen dapat menyebabkan gangguan terhadap kapasitas fungsional. Kapasitas fungsional yang rendah dikaitkan dengan peningkatan risiko kematian khususnya penyakit kardiovaskular.3 Di Indonesia, penyakit kardiovaskular penyebab kedua morbiditas dan mortalitas, bertanggung jawab atas sepertiga dari semua kematian di Indonesia.4 Penilaian kapasitas fungsional dapat memberikan informasi diagnostik, perbandingan pretreatment dan posttreatment, dan prediktor morbiditas dan mortalitas pada pasien dengan penyakit kardiovaskular dan berbagai klinis.2,5
THE INFLUENCE OF MAQASID SHARIAH PRACTICES ON SATISFACTION OF SHARIAH COOPERATIVE MEMBERS
Authors: Nopitasari Sinta , Bhinekawati Risa , Najib Muhammad 
Published: September 2023

This study aims at investigating the influence of five variables of Maqashid al Shariah on satisfaction of syariah cooperative members. The study gathered 200 respondents from nine sharia cooperatives in six provinces of Indonesia. Using multiple regression models, the collected data was tested and further analyzed using SPSS 24.0 Software. This research found that maintaining religion, human life, lineage, and wealth have positive and significant influence the satisfaction of shariah cooperative members, with level of confidence 95%. Meanwhile, maintaining intellect has no influence on the satisfaction of shariah cooperative members with level of confidence 95%. However, simultaneously, the five components of Maqashid al Shariah positively and significantly influence the satisfaction of shariah cooperative members with level of confidence 95%. This study contributes to the theory by giving empirical evidence that the concept of Maqashid al Shariah can be operationalized to measure satisfaction of shariah cooperative members, which has not been studied before. In practice, the management of shariah cooperatives can adopt the model developed by this study to improve the performance of their cooperatives
Unidade de Internamento Psiquiátrico para Jovens dos 15 aos 25 Anos: Um Estudo de Follow-up
Authors: Vaz Pinto Sofia , Oliveira Inês , Barroca Inês , Leal Beatriz , Mata Mónica , Garcia Ribeiro Catarina , Afonso Quintão Ana , Amaro Rita , Do Amaral Sarah , Cifuentes Rebeca , Caldeira da Silva Pedro , Salgado José 
Published: September 2023

Introdução: A adolescência e início da idade adulta, são fases do ciclo de vida marcadas por grandes transformações físicas, psicológicas e sociais. A faixa etária de transição, entre os15 e 25 anos, é considerada uma idade de risco para o desenvolvimento de psicopatologia, representando um período crítico de oportunidades e desafios para a intervenção em saúde mental. O nosso objetivo foi realizar um estudo de follow-up a 4 anos dos jovens internados durante o ano de 2018 na unidade de internamento agudo psiquiátrico Unidade Partilhada, destinado a jovens dos 15 aos 25anos de idade; pretendeu‐se avaliar as características sociodemográficas e clínicas da amostra, as características do internamento, a taxa de reinternamento, o estado psicopatológico, qualidade de vida, grau de satisfação com os cuidados prestados e manutenção do seguimento em consulta; estabelecendo relações entre as variáveis mencionadasMétodos: Entrevista telefónica padronizada, com aplicação da versão reduzida do Mental Health Inventory (MHI) e o Instrumento Abreviado de Avaliação da Qualidade de Vida da Organização Mundial de Saúde; consulta de processo clínico.Resultados: Há uma maior percentagem de doentes do sexo feminino (52,1%). O diagnóstico de alta de perturbaçãodo humor (54,3%) foi significativamente superior no sexo feminino e o de perturbação psicótica (23,4%) foi significativamente superior no sexo masculino (Fisher= 40; p<0,001). A duração do internamento (média=16,1 dias; DP=13,6 dias) foi significativamente superior para as perturbações psicóticas em comparação com as perturbações do humor (p=0,009). Dos jovens, 41,5% foram readmitidos, 6,3% num período inferior a 30 dias e 35,2% num período inferior a 365 dias. À data da entrevista de follow-up, 80,9% consideram estar “melhor”; e 62,7% estar “satisfeitos”ou “muito satisfeitos” com a sua vida. Mantêm acompanhamento em consulta 74,5%, sendo a pontuação do MHI significativamente inferior nos jovens sem seguimento atual. Referem estar “muito satisfeitos” ou “mais que muito” com o atendimento prestado, 37,2%.Conclusão: O conhecimento e obtenção de dados que permitam a caracterização do internamento psiquiátrico em idade de transição é fundamental para a planificação, organização e otimização dos cuidados prestados a esta população. A valorização da opinião do doente e a aproximação entre profissionais de saúde e doentes jovens, favorece a adesão ao tratamento.
TECNOLOGIA E EDUCAÇÃO: DESAFIOS E CONTRIBUIÇÕES NO PROCESSO DE ENSINO E APRENDIZAGEM
Authors: Santana Marleide Quaresma da Silva , Vieira Umberlândia Fernandes , Santos Maria Pricila Miranda dos 
Published: September 2023

As tecnologias tornam-se cada vez mais um fator de grande relevância na transformação em todas as áreas, facilitando a vidas das pessoas nos mais diversos setores. A educação por sua vez através das tecnologias apresenta mudanças no que se refere ao uso das tecnologias para fins pedagógicos, especialmente a partir do período da pandemia da Covid-19. Inserir as tecnologias de forma positiva na educação não é tarefa fácil, pois, exige esforço e preparo de todos que fazem parte da escola, constituindo assim um grande desafio pra professores e alunos, porém mesmo em meio a inúmeras demandas é possível perceber também suas grandes contribuições no processo de ensino e aprendizagem se utilizada com direcionamento.
PENGARUH KONSENTRASI DAN LAMA PERENDAMAN ZPT AUKSIN DALAM MEMPERCEPAT PERTUMBUHAN TUNAS BULBIL PORANG (Amorphophallus muelleri Blume)
Authors: Hasanah Qurrota Ayun Fahra , Sugiono Darso , Rahayu Yayu Sri 
Published: September 2023

Porang (Amorphophallus muelleri Blume) merupakan komoditi tanaman yang termasuk ke dalam famili Araceae dan merupakan tumbuhan semak (herba) dengan umbi tunggal di dalam tanah. Penggunaan zat pengatur tumbuh sebelum melakukan penanaman porang merupakan salah satu cara untuk mempercepat pertumbuhan tunas bulbil porang. Adapun tujuan dari penelitian ini adalah untuk mendapatkan konsentrasi dan lama perendaman yang memberikan pengaruh dalam mempercepat pertumbuhan tunas bulbil porang (Amorphophallus muelleri Blume). Percobaan ini dilaksanakan di Green House Telaga Desa, Kawasan Industri KIIC, Jl. Permata Raya, Puseurjaya, Telukjambe Timur, Karawang, Jawa Barat 41361. Pecobaan ini dilaksanakan pada bulan Maret sampai dengan Mei 2023. Metode penelitian yang digunakan adalah metode eksperimen menggunakan Rancangan Acak Kelompok (RAK) faktorial, yang terdiri dari 16 perlakuan diulang sebanyak 2 kali. Faktor pertama adalah Konsentrasi terdiri dari 4 taraf yaitu k0 (kontrol), k1 (200mg/l), k2 (300mg/l), dan k3 (300mg/l). Faktor kedua adalah Lama perendaman terdiri dari 4 taraf yaitu l1 (60 menit), l2 (120 menit), l3 (180 menit), dan l4 (240 menit). Terdapat interaksi antara konsentrasi dan lama perendaman terhadap waktu bertunas, indeks vigor, dan diameter tunas bulbil porang pada umur 42 hst dan 56 hst. Konsentrasi 200mg/l (k1) pada lama perendaman 180 menit (l3) memberikan hasil waktu bertunas tercepat yaitu 15,2 hari. Konsentrasi 200mg/l (k1) pada lama perendaman 240 menit (l3) memberikan nilai indeks vigor tertinggi yaitu 100%. Lama perendaman l4 (240 menit) pada konsentrasi ZPT k1 (200mg/l) memberikan diameter tunas bulbil porang terbaik yaitu 2,96 mm.
Kata Kunci : konsentrasi ZPT auksin, lama perendaman, porang
EVALUASI KEBERADAAN DAN STATUS AMBANG EKONOMI Lepidiota stigma F. PADA BEBERAPA LAHAN KOMODITI PERKEBUNAN
Authors: Assaad Andi Ridwan , Nurmiaty Nurmiaty , D Rahmad , Kumalawati Zahraeni 
Published: September 2023

Lepidiota stigma is known as a major pest and very destructive in sugarcane plants and some plantation commodities such as cocoa, coffee, and oil palm plants. The research aimed to determine of the presence and status of L. stigma as an initial anticipatory step in control activities. This research was designed as quantitative descriptive research on four fields, namely cocoa plantations, coffee plantations, oil palm fields, and empty land (thatch). The sample structure and observations were made following a diagonal line, which the observations of L. stigma were carried out when digging holes at a depth of 5 cm, 10 cm, and 15 cm in the sample area at a size of 1 x1 m., and five samples were taken from each field. The average observation results were analyzed descriptively with reference to the economic threshold value. The research results showed that L. stigma was found on all types of lands with a status below the economic threshold.

ABSTRAK
Hama Lepidiota stigma dikenal sebagai hama utama dan sangat merusak pada tanaman tebu dan beberapa komoditi perkebunan seperti kakao, kopi dan tanaman kelapa sawit. Penelitian bertujuan untuk melihat keberadaan dan status hama tersebut sebagai langkah antisipasi awal pada kegiatan pengendaliannya. Penelitian ini dirancang sebagai penelitian kuantitatif deskriptif yang menggunakan empat lahan, yaitu lahan tanaman kakao, lahan tanaman kopi, lahan sawit dan lahan kosong (ilalang). Struktur dan pengambilan sampel mengikuti garis diagonal pada lahan, dimana . pengamatan L. stigma dilakukan saat menggali lubang pada kedalaman 5 cm, 10 cm, dan 15 cm di dalam kuadran sampel pada ukuran 1 x 1 meter dan pada setiap lahan diambil sebanyak lima sampel.. Rerata hasil pengamatan dianalisis secara deskriptif dengan mengacu pada nilai ambang ekonominya. Hasil penelitian menunjukkan bahwa L.stigma ditemukan pada semua jenis lahan dengan status dibawah ambang ekonomi
PENGARUH TERAPI MUROTTAL AL-QUR’AN SURAH AL ISRA’ TERHADAP TINGKAT DISMENOREA PADA REMAJA PUTRI DI MADRASAH ALIYAH NEGERI 1 KARANGANYAR
Authors: Fatmawati Dita Kusuma 
Published: September 2023

ABSTRAK
Latar Belakang: Menurut WHO (Word Health Organitation) angka kejadian dismenore di Indonesia sebanyak 55%. Menurut Dinas Kesehatan Provinsi Jawa Tengah prevelensi kejadian dismenorea mencapai 56%. Studi pendahuluan di Madrasah Aliyah Negeri 1 Karanganyar menunjukan mayoritas mengeluhkan mengenai dismenorea dimana siswi mengalami kesulitan belajar dan beraktifitas dimana siswi ijin ke UKS dan pulang ke rumah. Salah satu penanganan dismenorea yaitu dengan terapi murottal al-qur’an. Tujuan : Mengetahui pengaruh terapi murottal Al-Qur’an Surah Al Isra’ terhadap tingkat dismenorea pada remaja putri di Madrasah Aliyah Negeri 1 Karanganyar. Metode: Penelitian kuantitatif dengan desain Quasi Eksperiment Design dengan rancangan One Group Pre-test dan Post-test menggunakan Teknik probability sampling dengan metode stratified random sampling, dengan sampel 15 responden. Pengumpulan data menggunakan instrument Numeric Rating Scale (NRS). Hasil: Setelah dilakukan analisa data menggunakan uji Wilcoxon didapatkan nilai median sebelum diberikan intervensi sebesar 3,00 dan setelah diberikan intervensi sebesar 2,00 dan Asymp.Sig.(2-tailed) (0,000)<0,05. Kesimpulan: Ada pengaruh terapi murottal Al-Qur’an Surah Al Isra’ terhadap tingkat dismenorea pada remaja putri di Madrasah Aliyah Negeri 1 Karanganyar.

Kata Kunci : Dismenorea, Terapi Murottal Al-Qur’an, Remaja Putri
Gambaran Status Kesehatan Reproduksi Pada Remaja Putri di SMPN 1 Mantingan
Authors: Ningrum Ucik Celsia , Sari Dewi Kartika 
Published: September 2023

ABSTRAK
Pendahuluan: Masa remaja merupakan masa peralihan antara masa anak-anak menuju masa dewasa yang diawali dengan terjadi kematangan seksual. Remaja di Indonesia saat ini sedang mengalami peningkatan kerentanan terhadap berbagai ancaman risiko kesehatan terutama yang berkaitan dengan kesehatan seksual dan reproduksi. Jumlah remaja pada tahun 2022 menurut data BPS (Badan Pusat Statistik) dari umur 15-19 tahun adalah 22.176.543 jiwa atau 8,05% dari total jumlah penduduk Indonesia. WHO menekankan pentingnya pendidikan kesehatan reproduksi kepada kelompok remaja awal usia 10-14 tahun. Metode: Jenis penelitian yang digunakan dalam penelitian ini menggunakan penelitian kuantitatif dengan pendekatan deskriptif dengan sampel 60 responden. Menggunakan kuesioner petunjuk teknik penjaringan kesehatan dan pemeriksaan berkala anak usia sekolah dan remaja. Hasil: Gambaran status kesehatan reproduksi mayoritas memiliki kategori kesehatan reproduksi yang kurang baik, dengan banyak remaja putri mengalami masalah keputihan dan gatal di area genitalia. Kondisi ini memerlukan perhatian dan upaya sosialisasi yang lebih intensif untuk meningkatkan pengetahuan dan kesehatan reproduksi remaja di sekolah tersebut. Simpulan: Gambaran status kesehatan reproduksi pada remaja putri di SMPN 1 Mantingan didominasi oleh kategori kurang, dengan 37 responden atau sebesar 61,7% mengalami kondisi kurang pada kesehatan reproduksi.

Kata Kunci: Kesehatan Reproduksi, Pelajar, Remaja Putri