bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Effects of Lateral Confinement on Concrete Columns Reinforced With Tmt Bars
Authors: Khan Muhammad Saad , Rafi Muhammad Masood , Varum Humberto 
Published: October 2023

Abstract
The details of experimental testing of full-scale reinforced concrete (RC) columns are presented in this paper. These columns were reinforced with hot-rolled thermo-mechanically treated (TMT) bars with yield strength higher than recommended in the prevalent manufacturing standards. The parameters of the study were the concrete confinement and concrete core area which were investigated using three specimen columns having lap-spliced longitudinal bars at the base. Although the initial cracks in all the columns were similar, the severely damaged region shifted in the vicinity of the end of dowel bars in the column with lesser confinement due to rebar slip. This type of behaviour influenced flexural rigidity and curvature distribution for this specimen. The maximum lateral load capacity and ductility of the specimen with lesser confinement were also the lowest. On the contrary, the specimen with higher confinement and core concrete area exhibited the highest stiffness and load capacity.
Laparoscopic Cholecystectomy in a patient with Situs Inversus Totalis: Anesthetic Challenges and Considerations, A case report
Authors: Mishra Mridul , Yadav Prashant , Adhikari Pratik , Yadav Pramodman Singh , Chaudhary Pratik , Adhikari Bikash , Shrestha Prashit , Uprety Pratik 
Published: October 2023

Abstract
Situs inversus is a rare congenital condition in which the abdominal organs are reversed. During embryological development, a 270-degree clockwise rotation leads to a mirror image transposition of both abdominal and thoracic organs. The incidence of situs inversus in the general population ranges from approximately 1 in 5000 to 1 in 20000. Situs inversus totalis can be associated with various anomalies such as transposition of the great arteries, septal defects, Kartagener syndrome and spinal dysraphism. However, there is no evidence to suggest that situs inversus predisposes to cholelithiasis or that cholelithiasis occurs with greater frequency in this population. Diagnosis of this condition commonly involves radiography and ultrasonography or by using advanced imaging modalities like Computed tomography(CT) or Magnetic resonance imaging(MRI).Despite the unique anatomical arrangement, individuals usually remain asymptomatic and can expect a normal life expectancy. However, when these individuals require surgical interventions, anesthetic complications may arise due to the associated anomalies. In this case study, we present the challenges encountered by an anesthesiologist during a laparoscopic cholecystectomy on a 58-year-old male diagnosed with situs inversus and symptomatic cholelithiasis.
Effect of deposition time on the optical properties of vanadium pentoxide films grown on porous silicon nanostructure
Authors: Ktifa Skander , Rahmani Mahdi , Bouaicha Mongi 
Published: October 2023

Abstract
Vanadium pentoxide (V2O5) thin films were grown on porous silicon (PS) layer by electron beam evaporation technique under an oxygen partial pressure. The morphology of the porous surface before and after V2O5 deposition for different evaporation times was observed by the Scanning Electron Microscope (SEM). The predicts changes of the chemical composition and bonds at the porous surface have been studied by FTIR and Raman spectroscopies. Photoluminescence (PL) spectroscopy was carried out to study the effect of vanadium pentoxide thickness on the optical properties of V2O5/PS nanocomposites. The PL spectrum of PS show a red-shift of 90 nm following the deposition of vanadium pentoxide while a quenching of the PL intensity was observed. Referring to FTIR and Raman results, the origin of this shift can be attributed to the formation of oxidized vanadium elements at PS surface as well as the creation of localized states by V2O5 molecules inside the band gap of PS. The wavelength dependence of optical transmittance, reflectance and absorption coefficients were investigated. An increase in the optical band gap from 1.95 eV to 2.18 eV was obtained due to Moss-Burstein effect as well as the presence of vacancy defects in V2O5 film.
Study of the Preparation and Quality of Gastrodia elata with Different Drying Processes
Authors: Wang Nannan , Jin Xindi , Li Yongxiang , Zhao Tong , Lu Yangyang , Chang Jiale , Liu Bin , Gao Zhenpeng , Zhao Xubo 
Published: October 2023

Abstract
The objective of this study was to evaluate the effects of different drying methods on the quality of fresh Gastrodia elata after drying and processing. Four drying methods, including natural air drying, hot air drying, vacuum freeze drying, and vacuum microwave drying, and two pre-treatment methods (unprocessed and steam processed) were used. Scanning electron microscopy was used to observe the microstructure of dried Gastrodia elata, and high-performance liquid chromatography was used to measure the content of eight functional components such as gastrodin, p-hydroxybenzyl alcohol etc. The in vitro antioxidant and hypotensive experiments were also conducted. The results showed that pre-treatment methods and different drying methods had a significant effect on the morphology and functional component content of Gastrodia elata. The steam processed-vacuum freeze drying (PGB-CFD) treatment group had the highest functional component content, with a total content of 42.71 mg/g. The unprocessed-vacuum freeze drying (NGB-CFD) treatment group had the highest antioxidant capacity, while the steam processed-vacuum freeze drying (PGB-CFD) treatment group had the highest ACE enzyme inhibition rate. This study provides reference methods and basic data for the further processing of fresh Gastrodia elata.
WITHDRAWN: Land cover changes based on open spatial data - a case study
Authors: Głogowska Magdalena 
Published: October 2023

Abstract

Context Cities have been facing the problem of disappearance of open green areas in favor of built-up areas. There is a fragmentation of these areas and eventually their loss. In areas where the land surface is successively built upon, the risk of flooding and water scarcity increases, and in many places the phenomenon of urban heat island occurs.Objectives The aim of the work is to identify and determine the extent and rate of disappearance of green areas and to understand the nature of these changes. Another objective of the work was to test the usefulness open spatial resources for analyzing land cover change at a smaller scale.Methods These analyzes were performed using open spatial data from the Copernicus Land Monitoring Service. The data includes land use and land cover (LULC) derived from satellite imagery for functional urban areas (FUA). Three cities were selected from Katowice FUA (includes 58 municipalities) and the analyzes of GIS were conducted at this scale.Results Changes in land use in cities: Gliwice, Chorzów and Sosnowiec over a period of 6 and 12 years were analyzed. In addition, the suitability of the Copernicus resource for this scale of analysis was examined.Conclusions The study confirms the general trend of the disappearance of green spaces in favor of built-up areas. In addition, assessing the quality of open spatial data is crucial to ensure reliable analysis of land cover changes in order to properly manage these resources and improve the standard of living of residents.
The role of microRNAs in understanding sex-based differences in Alzheimer's disease
Authors: Llera-Oyola Jaime , Carceller Héctor , Andreu Zoraida , Hidalgo Marta R. , Soler-Sáez Irene , Gordillo Fernando , Gómez-Cabañes Borja , Roson Beatriz , Iglesia-Vayá Maria de la , Mancuso Roberta , Guerini Franca R. , Mizokami Akiko , Garcia Francisco Garcia 
Published: October 2023

Abstract

Background:The incidence of Alzheimer's disease (AD) - the most frequent cause of dementia - is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles of regulatory factors such as microRNAs (miRNAs) could contribute to more accurate disease diagnosis and treatment.Methods:A systematic review identified five studies of microRNA expression in AD patients that incorporated information regarding the biological sex of samples in the Gene Expression Omnibus repository. A differential microRNA expression analysis was performed, considering disease status and patient sex. Subsequently, results were integrated within a meta-analysis methodology, with a functional enrichment of meta-analysis results establishing an association between altered miRNA expression and relevant Gene Ontology terms.Results:Meta-analyses of miRNA expression profiles in blood samples revealed the alteration of sixteen miRNAs in female and twenty-two miRNAs in male AD patients. We discovered nine miRNAs commonly overexpressed in both sexes, suggesting a shared miRNA dysregulation profile. Functional enrichment results based on miRNA profiles revealed sex-based differences in biological processes; most affected processes related to ubiquitination, regulation of different kinase activities, and apoptotic processes in males, but RNA splicing and translation in females. Meta-analyses of miRNA expression profiles in brain samples revealed the alteration of six miRNAs in female and four miRNAs in male AD patients. We observed a single underexpressed miRNA in female and male AD patients (hsa-miR-767-5p); however, the functional enrichment analysis for brain samples did not reveal any specifically affected biological process.Conclusions:Sex-specific meta-analyses supported the detection of differentially expressed miRNAs in female and male AD patients, highlighting the relevance of sex-based information in biomedical data. Further studies on miRNA regulation in AD patients should meet the criteria for comparability and standardization of information.
Towards reliable national social footprints: refining work-related injury and fatality metrics
Authors: Berthet Etienne , Anquetil-Deck Candy , Stadler Konstantin , Laurent Alexis 
Published: October 2023

Abstract
Objectives:
The objective of this data note is to provide a reliable, comprehensive dataset focusing on work-related injuries and fatalities, broken down by year, country, gender, and economic sector. We aim to fill a significant gap in sustainability models, specifically in metrics concerning occupational health. Although the data is compatible with any Multi-Regional Input-Output (MRIO) model, it is primarily designed for integration with the EXIOBASE model. The dataset seeks to broaden MRIO models' capabilities in social impact assessments and national social footprint evaluations. Ultimately, this resource aims to offer a holistic tool for researchers and policymakers, enabling more thorough assessments of international trade flows, global value chains (GVC), and national policies across both environmental and social dimensions.
Data Description:
Our dataset enriches the EXIOBASE model with updated fatality statistics from World Health Organization (WHO) and Eurostat databases, covering the years 2008 to 2019. It provides detailed data on work-related fatal injuries by country, gender, and economic sector. With its broad applicability, this dataset stands to influence research and policy across multiple disciplines. It offers valuable insights for studies on global social impacts, policy economics, and the real effects of global value chains, among other research areas.
Pharmacodynamics and biodistribution of radiolabeled Platinum-195m (Cisspect) in head and neck squamous cell carcinoma
Authors: de Roest Reinout H. , Walsum Marijke Stigter – van , Schilden Karlijn van der , Brakenhoff Ruud H. 
Published: October 2023

Abstract
Background
Cisplatin- based chemoradiotherapy is a crucial pillar in the treatment of HNSCC. The use of cisplatin comes with a high burden as 35% of patients cannot sustain the planned dose. Unfortunately, there are no clinically applicable biomarkers to predict response. Based on the association of response with the number of DNA adducts and the involved molecular pathway to resolve cisplatin-induced DNA crosslinks in HNSCC, [195mPt]Cisplatin (CISSPECT®) promises to be a potential biomarker of response using imaging and biodistribution. The aim of this study is to investigate the biodistribution of [195mPt]Cisplatin between known cisplatin-sensitive (VU-SCC-1131) and –resistant (VU-SCC-OE) HNSCC cell lines in vitro and xenografts in mice in vivo.
Results
Being more sensitive to cisplatin than VU-SCC-OE, cell cycle experiments showed a severely hampered G1 and S-phase in VU-SCC-1131 after low dose treatment with cisplatin compared to VU-SCC-OE. Remarkably, VU-SCC-OE was able to accumulate more [195mPt]Cisplatin in the DNA, and showed an increased capability to repair Pt-195m cisplatin crosslinks as compared to VU-SCC-1131. Notably, uptake increased even when cisplatin was removed from the medium, likely by intracellular sources. In vivo, [195mPt]Cisplatin was rapidly distributed to large organs and similar between intravenous and intraperitoneal administration. Most of circulating [195mPt]Cisplatin was cleared by renal filtration, and accumulation in kidney and liver remained high. Uptake in xenografts was rapid (blood:tumor ratio; 1:1) and highest after 1 hr, while decreasing after 6 hrs in accordance with the circulating concentration. Remarkably, there was no significant difference in uptake and retention between xenografts of the sensitive and resistant cell line.
Conclusion
VU-SCC-1131 with an FA deficiency and VU-SCC-OE displayed a significant difference in sensitivity to and recovery from cisplatin, due to a S-phase problems in VU-SCC-1131 at low dose in line with the genetic defect. Using Pt-195m radioactivity analysis, we demonstrated the limited capability of cisplatin crosslink repair in VU-SCC-1131. We were not able to translate these findings to a mouse model for sensitivity prediction based on the biodistribution in the tumor. The organ-specific distribution data of [195mPt]Cisplatin could possibly be used to predict the toxic side-effects of cisplatin and facilitate optimizing therapeutic dosing schemes.
Clinical evaluation of the Vaginal Panel Realtime PCR Kit (Vircell, SL) for the diagnosis of vaginitis
Authors: Amor Isabel , Alberola Ana , de Salazar Adolfo , Viñuela Laura , Úbeda-Portugués Sara , Galán María Isabel , Mendoza Pablo , García Federico 
Published: October 2023

Abstract
Vaginitis is a common clinical disorder for which women seek medical care. A clinical evaluation of the Vaginal Panel Realtime PCR kit (qPCR test) compared with reference methods was performed. A total of 1011 vaginal swab specimens were analyzed. The reference methods were Gram strain-based Nugent score combined with Gardnerella culture for bacterial vaginosis (BV) diagnosis and culture for Candida species and Trichomonas vaginalis detection. Candida species identification was performed using matrix-assisted laser desorption ionization-time of flight mass spectrometry. The agreement between both methods for BV was 93.11% with a Kappa value of 0.82 (95% confidence interval 0.781–0.860). The sensitivity, specificity, positive predictive value and negative predictive value of the qPCR test compared to the reference method for Candida species were 96% (95% confidence interval 92.8%-98.1%), 98.4% (95% confidence interval 97.2%-99.2%), 95.3% (95% confidence interval 92.0%-97.3%) and 98.7% (95% confidence interval 97.6%-99.3%), respectively. The qPCR test yielded a positive result for T. vaginalis in twelve of the specimens however the parasite was not microscopically observed in any cultured specimens. The Vaginal Panel Realtime PCR kit showed an optimal agreement compared to reference methods for vaginitis diagnosis, even improving the detection of T. vaginalis.
Facile Synthesis of MgO-Carbon nanocomposites for Advanced Capacitive Electrode Materials
Authors: mondal aniruddha , Afzal Mohd , Mondal Sudip 
Published: October 2023

Abstract
The current study aims to develop a unique approach for constructing an asymmetric supercapacitor utilising a nanocomposite of MgO-Carbon as electrode material. The geometrical surface area of the MgO-Carbon has shown to be highly porous with different porosities, and the value is 210 m2g− 1. This supercapacitor operates with an aqueous electrolyte consisting of 1M KOH. The findings indicate that the test cell exhibited exceptional electrochemical output within the voltage range of 0 to 1 V. The capacitance of the MgO-Carbon cell is measured to be 225 F g− 1 at a current density of 2 A g− 1. According to research on cycling, the aforementioned cell has demonstrated the ability to maintain 97% of its original capacitance following 20,000 cycles. The findings of this study suggest that the MgO-Carbon holds promise as an electrode material for the development of environmentally friendly and cost-effective energy storage devices. This composite exhibit excellent energy and power densities, along with a prolonged cycle life.
MALDI-TOF Nucleic Acid Mass Spectrometry for Simultaneously Detection of Fourteen Porcine Viruses and its Application
Authors: Shuai Jiangbing , Song Shiqi , Wang Zhongcai , Zeng Ruoxue , Zhang Xiaofeng 
Published: October 2023

Abstract

Background: Porcine respiratory and digestive diseases pose significant challenges in modern pig farming, often arising from mixed infections involving various pathogens. Current methods for detecting viral porcine pathogens have notable limitations in simultaneously identifying multiple pathogens. To address this issue, our study introduces a novel methodology that combines single-base extension PCR with matrix-assisted laser desorption/ionization time-of-flight nucleic acid mass spectrometry (MALDI-TOF NAMS).
Results: Our approach accurately simultaneously identified 14 critical porcine viruses, including porcine circovirus types 1 to 3, porcine bocaviruses groups 1 to 3, African swine fever virus, pseudorabies virus, porcine parvovirus, torque teno sus virus, swine influenza virus, porcine reproductive and respiratory syndrome virus, classical swine fever virus, and foot-and-mouth disease virus. The low limit of detection for multiplex identification ranges from 13.54 to 1.59 copies/μL. Inter- and intra-assay stability was found to be ≥98.3%. In a comprehensive analysis of 108 samples, the assay exhibited an overall compliance with qPCR results of 97.88%.
Conclusions: The developed MALDI-TOF NAMS assay exhibits high sensitivity, specificity, and reliability in detecting and distinguishing a wide spectrum of porcine viruses in complex matrix samples. This underscores its potential as an efficient diagnostic tool for disease surveillance and control in the pig industry.
Fecal microbiota transplantation in treating methylmercury-poisoned rats: Reconstruction of gut microbiome and modulation of gut-brain axis related metabolites
Authors: Zhang Yanfei , Xie Hongxin , Lin Xiaoying , Tian Xue , Ao Piaoxue , Cui Liwei , Xin Yan , Yin Ming , Shi Nianqiu , Li Bai , Gao Yuxi , Shang Lihai , Li Yu-Feng 
Published: October 2023

Abstract
Background Methylmercury (MeHg) can bring devastating neurotoxicity to animals and human beings. Gut microbiota has been found to demethylate MeHg while MeHg exposure was found to destroy the diversity and abundance of gut microbiota. Besides, some neurotransmitters such as GABA, glutamate and other metabolites were altered due to MeHg exposure. Fecal microbiota transplantation (FMT) has been successfully applied to treat a series of diseases like Tourette syndrome, irritable bowel syndrome, necrotizing enterocolitis and to treat ulcerative coliti. The objective of this study was to investigate the effects of FMT in treating MeHg-poisoned rats.
Results: It was found that FMT for 14 days promoted body weight gain, enhanced demethylation of MeHg and increased fecal excretion of Hg in MeHg-poisoned rats. Furthermore, the gut microbial bacteria associated with demethylation, such as sulfate-reducing bacteria were restored and some metabolites related to neuroactivity through gut-brain axis were increased after FMT, there is also repair of brain derived neurotrophic factor(BDNF)-related factor levels in the intestine, brain and serum.
Conclusions: In all, it was showed that FMT can be a effective way in treating MeHg-poisoned rats through the reconstruction of gut microbiota, especially the bacteria that are associated with the demethylation of MeHg. Furthermore, the modulation of metabolites that are related to gut-brain axis after FMT also contributed to the treating of MeHg-poisoning. This study provides a novel way to treat MeHg-poisoning, which may contribute to the health promotion of mercury exposed population and shed lights on the treatment of other neurological diseases like Parkinson’s disease.
Comparison of Predictability in Vault using NK Formula and KS Formula for the Implantable Collamer Lens Surgery
Authors: Zhong Xin , Li Yan , Li Yuancun , Wang Geng , Du Yali , Zhang Mingzhi 
Published: October 2023

Abstract

Background The purpose of this study is to investigate the agreement of NK and KS formulas in predicting the vault after implantation of EVO-implantable collamer lens (ICL).Methods In this retrospective study, a total of 106 eyes of 59 patients who underwent ICL-V4c implantation were included. The predicted vault using the NK formula and the KS formula was provided by anterior segment optical coherence tomography (AS-OCT) automatically. The achieved vault was measured by AS-OCT at 1 month after surgery. Multivariate linear regression analyses were performed for evaluating correlations between postoperative vault and other biological parameters.Results The achieved vault was 604.34 ± 214.66 µm, which was significantly smaller than the predicted vaults of 713.50 ± 195.32 and 679.27 ± 211.00 µm, using the NK and KS formulas, respectively (P < 0.05). The 95% limits of agreement of the achieved vault and the predicted vault using the KS formula were narrower than those of the achieved vault and the predicted vault using the NK formula in both ICL size groups. Anterior chamber depth (ACD) and sulcus-to-sulcus diameter (STS) were independent factors associated with achieved vault (P < 0.05). It’s no significant difference in absolute prediction error (APE) between the two formulas.Conclusion There is no significant difference between the NK and KS formulas in terms of absolute predicted error vault. It should be noted that AS-OCT tended to overestimate the predicted ICL vault, particularly when selecting larger ICL sizes. ACD and STS were identified as potential crucial factors influencing the achieved vault.
Diagnostic value of combined-diagnostic methods of brain tuberculoma tissue specimens: a case series
Authors: Liang Bo , Yang Siyuan , Zhou Xingang , Ding Xinghuan , Wang Jianbo , Li Jingjing , Gao Haili , Zhao Hongxin , Liang Tingyu , Feng Enshan 
Published: October 2023

Abstract

Background: The diagnosis of brain tuberculoma (BT) is sometimes challenging. Herein, we presented a case series to evaluate the combined-diagnostic methods, including acid-fast bacilli (AFB) stain, polymerase chain reaction (PCR), Gene Xpert and histopathology, of tuberculoma tissue specimens (TTSs).
Methods: A total of 16 patients (11 HIV-positive, 5 HIV-negative) with BT confirmed by combined-diagnostic methods of TTS were included in this study. Clinical data, including clinical symptoms, laboratory tests, neuroimaging features, histopathology, treatment, and prognosis, were assessed in all patients.
Results: There were 10 male and 6 female patients (range: 18-73 y). AFB stain and PCR of TTSs were positive in 11 and 10 patients, respectively. The sensitivity of Gene Xpert of TTSs was (80.0%, 8/10). 9 (56.3%, 9/16) patients were diagnosed with BT by histopathology.After receiving anti-tuberculosis treatment, 12 (75.0%, 12/16) patients improved clinically to a considerable extent.
Conclusions: The combined-diagnostic methods of TTS may significantly improve the diagnostic efficiency of BT.