bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enucleation and Dermato-fat Graft for Retinoblastoma Management : A Case Report
Authors: SIMANJUNTAK Dr. AGNES ANGELA MAHDALENA , Anne Umboh , Freili Akay 
Published: February 2024

Introduction : Retinoblastoma is the most common intraocular malignant tumor found in children before 3 years old can occur unilaterally, bilaterally, hereditary or sporadic. Incidence of about 1:14,000-20,000 individuals. This tumor originated from embryogenic retinal cells. Retinoblastoma gene (RB1) located in the 13q14 chromosome
Case Illustration : A 3-year-old girl presented with leukocoria. Her parents notice whitish in her right eye swollen, teary, painful since 2 months ago. No family history. Visual acuity (VA) on the oculus dextra ( OD) no light perception, oculus sinistra (OS) 6/6. Intraocular pressure on OD n-1/palpation, OS n/palpation. Examination under anasthesia for diagnostic found there weren’t palpebral edema, conjunctival injection, hazy cornea, pupil, lens couldn’t be evaluated on OD. Ultrasound showed sugest vitreous seeding and ptisis. CT scan showed solid mass with calcification and diagnosed retinoblastoma stage group E. Patient was treated with chemoreduction using Vincristine, Etoposide, Carboplatine combined enucleation with dermato-fat graft. We did nervus opticus dissection and histopathological examination which showed retinoblastoma.
Discussion : The common signs of retinoblastoma is leukocoria. The priority is saving life followed by globe preservation. Treatment based on the stage of the disease. We did chemotherapy in this patient, followed by enucleation and dermato-fat graft. Enucleation stills the main therapy for saving life with nervus opticus dissection as possible. Dermato-fat graft has been shown to grow along with the expanding orbit in children therefore shows cosmetics.
Conclusion : This report illustrates a case of Retinoblastoma. The chemotherapy and enucleation using safe dermato-fat graft procedure with implant followed by a well fitted prosthesis for better cosmetics
Spontaneous Globe Rupture due to Neglected Glaucoma: How can it be?
Authors: Firdausi Asri Ayu , Kunhermawan Cosmas Hascaryanto , Lestari Chindhia Rima Rochmatika Bunga 
Published: February 2024

Introduction: Globe rupture is usually associated with spontaneous traumatic processes with the worst prognosis. The occurrence without prior trauma is only reported in small numbers of cases. This paper will describe a globe rupture in glaucomatous eye and share our experience with its management.
Case Illustration: A 66-year-old male presented to the emergency department (ED) with reddish and progressive pain in the right eye (RE) followed by severe headaches for the last three days. On history taking, the patient complained of a progressive blurry vision to total blindness of his RE for 1 year. The patient admitted to having a history of glaucoma on previous primer examination but did not routinely control it. On initial examination, the patient was hypertensive , and suddenly began bleeding within 10 minutes upon arrival at ED. The diagnosis of globe rupture was made and he underwent emergency evisceration.
Discussiona: Spontaneous globe rupture is very rare, with an incidence of 3 per 100.000 in the United States, while no definite number is found in Indonesia due to the rarity. In glaucoma patients, spontaneous globe rupture is postulated to occur due to suprachoroidal hemorrhage. Our patients had multiple risk factors such as advanced age, systemic hypertension, and chronic untreated glaucoma. Evisceration went down to reduce pain, stop bleeding and prevent the spread of infection. Performing surgery within 10 days of the initial injury suggests a lower risk of post-operative endophthalmitis or sympathetic ophthalmia.
Conclusion: Spontaneous globe rupture in neglected chronic glaucoma has a very poor outcome but preventable.
Peripheral Ulcerative Keratitis: A Serious Corneal Inflammation
Authors: Fitrah  , Havizra Vitresia  , Getry Sukmawati  
Published: February 2024

Abstract
Introduction : Peripheral ulcerative keratitis (PUK) is a rare, but severe sight-threatening inflammatory condition that affects the cornea. PUK is characterized by peripheral corneal ulceration, stromal thinning, and neovascularization that can lead to corneal perforation and vision loss. Although PUK can occur in individuals without underlying systemic disease, it is most commonly associated with autoimmune disorders.
Case Illustration : A 53-year-old woman presented to the ophthalmology clinic with complaints of redness, foreign body sensation, and blurred vision in her both eye for the past three days. On examination, slit-lamp biomicroscopy revealed a peripheral corneal ulcer. She had a history of rheumatoid arthritis for the past 2 months and was being treated with methotrexate and metylprednisolone. Laboratory investigations revealed elevated Anti-CCP IgG, which confirmed the presence of rheumatoid arthritis.
Discussion : PUK is most commonly associated with autoimmune disorders, particularly rheumatoid arthritis, but may also occur in individuals with infectious, degenerative or traumatic corneal injuries. Immune- mediated inflammation, complement activation, and tissue destruction are thought to be involved in the pathogenesis of PUK. The diagnosis of PUK requires a thorough ophthalmic examination, including slit-lamp biomicroscopy, and laboratory investigations for underlying autoimmune disorders.
Conclusion : PUK is a rare but serious ocular disease that requires prompt diagnosis and management to prevent severe complications such as corneal perforation and vision loss. Although PUK can occur in individuals without underlying systemic disease, it is most commonly associated with autoimmune disorders, particularly rheumatoid arthritis.
Validity and Reliability of Farra Eye Model as a Surgical Simulator for Capsulorhexis Training
Authors: HANIFAH RAHMANI NURSANTI  , Julie Dewi Barliana  , Syska Widyawati  , Faraby Martha  , Levina Chandra Khoe  
Published: February 2024

Abstract
Introduction & Objectives : Various simulation models are available for cataract surgery training. Farra Eye Model, a new cataract surgery simulator, was developed to provide the resident with more affordable options. This study aims to determine the validity and reliability of the Farra Eye Model as a surgical simulator for capsulorhexis training.
Methods : A cross-sectional pilot study was performed among ophthalmology residents and consultants to assess face, content, and construct validity of a new surgical simulator. Subjects were divided into novice, intermediate, and expert groups according to their level of expertise. Face and content validity was assessed using a validated questionnaire with a 5-point Likert scale response. Construct validity was done by comparing capsulorhexis performance between the three groups. Two raters assessed performance using capsulorhexis indices in ICO-OSCAR: Phaco assessment tool, number of forceps grabs, and duration of capsulorhexis.
Results : A total of 33 subjects were recruited and divided equally into three groups. The overall face validity score was favorable (3.67 ± 0.67). However, the capsule elasticity was rated poor (2.73 ± 1.1) among the intermediate group. The content validity was favorable regarding the overall score (4.15± 0.58) and each assessment component. In the construct validity test, intermediate and expert groups showed better capsulorhexis performance than the novice group on all parameters (p<0.001), with good inter-rater reliability (ICC>0.7).
Conclusion : Farra Eye Model has a good face and content validity for capsulorhexis training and is able to differentiate the novice group from intermediate and expert groups. However, it remains a challenge to replicate human lens capsule elasticity.
Sudden Ocular Complication after Snake Bite
Authors: Hadrani Farah Hayati , Oktaputri Anita , Widodo Galih , Susetio Yoseph 
Published: February 2024

Introduction : A snakebite constitutes a common acute medical emergency and has several systemic and even ocular consequences. Snake venom neurotoxins act mainly on the peripheral nervous system at the neuromuscular junction and can affect the cranial nerves. Neurological symptoms that relate to cephalic muscle paralysis include exotropia, ptosis, diplopia and ophthalmoplegia.
Case Illustration : A 17 years old man came to emergency department with painful swelling on his left hand and sudden blurred vision right after his left hand were bitten by venomous snake in the rice field. Diplopia and ptosis were developed several hours after admission. On eye examination, visual acuity was 0,05 on right eye and 0,8 on left eye, abnormal pupillary reflects on both eyes were present, pupil dilatation, limited eye movement and ptosis were present, Intraocular pressure were 23,7 mmHg on right eye and 24,5 mmHg on left eye. Antivenom was administered immediately. He received cycloplegic, timolol eyedrop, and prednisolone eyedrop for ocular treatment
Discussion : Ocular complications are rare and uncommon but they may lead to sight-threatening conditions. Snake venom neurotoxins act mainly on the peripheral nervous system at the neuromuscular junction and can affect the cranial nerves. Mild neurological symptoms that relate to cephalic muscle paralysis include exotropia, ptosis, diplopia and ophthalmoplegia.
Conclusion : This study presented a rare case of systemic ocular complication as a result of a snake bite. Ophthalmoplegia induced ocular discomfort for an extended period is a rare symptom of snake-bites. Combined treatment of steroid with antivenom may improve the recovery from sudden ocular manifestation in snake bite.
Predicting Cardiovascular Risk in People With Diabetic Retinopathy : Study Using Framingham Risk Score
Authors: Harahap Vicia Belladona Carolina , Metita Mirza , Dewi Nadia Artha 
Published: February 2024

Introduction: People with type 2 diabetes have an increase risk of cardiovascular disease (CVD). Framingham risk score is used to determine 10 years the risk of CVD in asymptomatic patients for primary prevention. Up to now, there have been no similar studies regarding the risk of CVD in diabetic retinopathy (DR) patients in Indonesia. Therefore, we would like to investigate the corelation between DR and CVD risk through the population using Framingham risk score.
Methods: This research is a Population-Based Cross-sectional Study. The data was taken from the villages in Malang Regency. Participant with diabetes aged > 40 was recruited. The available data was then processed according to the variables and assessed using Framingham Risk Score. The scores were classified as high, intermediate, and low risk.
Results: From 953 samples there were 155 respondents with Diabetes Mellitus (DM), 23 of them experience DR. There were more female participants than men in DM group without DR (73.9%) and DR group (73.9%). A significant correlation between diabetic retinopathy and CVD risk was found (r=0.407, p=0.001). The risk of CVD in 10 years is low in diabetic patients without retinopathy ( p=0.001), but in patients with diabetic retinopathy, the risk of CVD in 10 years is intermediate-high (p=0.001).
Conclusion: There is corelation between Diabetic Retinopathy and risk for cardiovascular disease in intermediate-high category using Framingham risk score.
Navigating Through The Diagnostic and Management Maze of Atypical Optic Neuritis Due To Autoimmune
Authors: Andi Marsa Nadhira  , Syntia Nusanti  , Salmarezka Dewiputri  , Sita Paramita  , Muhammad Sidik  
Published: February 2024

Abstract
Introduction : Typical and atypical optic neuritis (ON) have many overlapping characteristics; however, atypical ON have different features, with more lasting visual impairment and devastating prognosis. This paper describes a challenging case of recurrent, atypical ON due to autoimmune.
Case Illustration : 42-year-old female complained of recurrent attacks of bilateral blurry vision, eye pain, and headachefor the past two years. Patient had been on multiple rounds of high-dose oral methylprednisolone, but symptoms reappeared every time it was tapered down. Visual acuity of both eyes was 3/60 and 6/45 (without and with correction, respectively), with normal intraocular pressure, anterior and posterior segment, and cranial nerves. No relative afferent pupillary defect was present. Brain magnetic resonance imaging (MRI) revealed intracerebral chronic small vessels; with no lesion in both optic nerves nor signs of neuromyelitis optica. Blood work-up showed elevated C-reactive protein, platelet aggregation, fibrinogen, D-dimer; positive rheumatoid factor, antinuclear antibody, and lupus anticoagulant; and negative Aquaporin-4 IgG. Diagnosis of atypical ON was established. Internal medicine and neurology departments diagnosed her with non-radiographic axial spondyloarthritis and migraine due to attributed autoimmune, respectively. After administration of intravenous pulse dose of methylprednisolone, her vision recovered to 6/7,5 of both eyes and symptoms alleviated.
Discussion : Atypical features usually give hints for atypical ON, while laboratory examination and imaging modalities may aid in etiology identification. Early immunosuppressant therapy is commonly required.
Conclusion : Recognizing symptoms of ON and necessitating further evaluation through ancillary tests, and collaborations with other specialties can minimize long-lived ailment and improve patients’ quality of life.
Surgical Strategies for Divergence Excess: A Comparison of True Divergence Excess and Pseudo-Divergence Excess Cases
Authors: Anshari Harsya Luthfi , Julita  
Published: February 2024

Introduction : True divergence excess (True DE) intermitent exotropia (IXT) is characterized by a greater deviation at distance than near ?10 prism diopters, while pseudo-divergence excess (Pseudo-DE) has greater deviation at distance than near but the difference becomes minimal after patching. Bilateral Lateral Recess (BLR) and Monocular Recess Resect (MRR) are commonly chosen for surgical planning.
Case Illustration : Case 1, a 4-year-old female presented with squint since 1 year old. Hirschberg test showed XT 15° in near (N) and 30° in distance (D). Prism alternate cover test (PACT) result was 30 ?D (N) and 60 ?D (D). Case 2, a 4-year-old female presented with squint since 6 months old. Hirschberg test showed XT 30° (N) and 45° (D) and dominant right eye. PACT result was 70 ?D (N) and 80 ?D (D). Poor fusion was found in both cases. Both patients underwent monocular patching for 30 minutes. We diagnosed patient 1 with True DE and BLR was done, while patient 2 with IXT dominant right eye Pseudo-DE and MRR was done on the left eye.
Discussion : First case was a patient with True DE who underwent 8-mm BLR, while second case was Pseudo-DE with dominant right eye who underwent monocular recess 11 mm and resection 8 mm on the left eye. Orthophoria was found after surgical correction in both cases.
Conclusion : Surgery management in True DE and Pseudo-DE are challenging, especially in determining the amount of surgery dosage and it depends on surgeon's experience. Both cases achieved successful outcomes with surgical correction resulted in orthophoria.
A Multiply-And-Max/min Neuron Paradigm for Aggressively Prunable Deep Neural Networks
Authors: Prono Luciano , Bich Philippe , Boretti Chiara , Mangia Mauro , Pareschi Fabio , Rovatti Riccardo , Setti Gianluca 
Published: February 2024

The growing interest in Internet of Things and mobile Artificial
Intelligence applications is pushing the investigation on Deep Neural
Networks (DNNs) that can operate at the edge using low-resources/energy
devices.
To obtain such a goal, several pruning techniques have been proposed in
the literature. They aim to reduce the number of interconnections - and
consequently the size, and the corresponding computing and storage
requirements - of DNNs that traditionally rely on classic
Multiply-and-ACcumulate (MAC) neurons.
In this work, we propose a novel neuron structure based on a
Multiply-And-Max/min (MAM) map-reduce paradigm, and we show that by
exploiting this new paradigm it is possible to build naturally and
aggressively prunable DNN layers, with a negligible loss in performance.
This novel structure allows a greater interconnection sparsity when
compared to classic MAC-based DNN layers. Moreover, most of the already
existing state-of-the-art pruning techniques can be used with MAM layers
with little to no changes.
To test the pruning performance of MAM, we employ different models -
AlexNet, VGG-16 and the more recent ViT-B/16 - and different computer
vision datasets - CIFAR-10, CIFAR-100 and ImageNet-1K. Multiple pruning
approaches are applied, ranging from single-shot methods to
training-dependent and iterative techniques.
As a notable example, we test MAM on the ViT-B/16 model fine-tuned on
the ImageNet-1K task and apply one-shot gradient-based pruning. We
remove interconnections until the model experiences a 3% decrease in
accuracy. While MAC-based layers need at least 56.16% remaining
interconnections, MAM-based layers achieve the same accuracy with only
0.04%.
Condition Survey Of Badminton Enthusiasts In Sragen Regency In 2023
Authors: Sunjoyo  , Sholeh Muchhamad , Sakti Rumpoko Satrio , Septi Sistiasih Vera , Kuntum Mandalawati Titin , Rasyid Anwar 
Published: February 2024

Physical fitness is one of the important physical components and must be owned by athletes to support in the game of badminton. This study aims to determine Physical Conditions which include Arm Muscle Strength, Flexibility, Leg Muscle Power, and Speed of Sragen Regency Badminton Athletes in 2023. The research method used is the Survey method. The study population numbered 60 people. Sampling using purposive sampling technique. Data collection techniques using Tests and Measurements. Data analysis techniques use descriptive statistical techniques. The results of the study were obtained that: Physical Condition Survey of Badminton Athletes in Sragen Regency in 2023 in the "Less Once" category of 3.33% (1 athlete), "Less" category of 30.00% (9 athletes), "Enough" category of 40.00% (12 athletes), "Good" category of 20.00% (6 athletes), and "Very Good" category of 6.67% (2 athletes) Based on physical condition data, Sragen Regency Badminton Athletes are included in the "sufficient" category.
Dynamics of Social Interaction in Virtual English Classes: A Virtual Ethnographic Approach
Authors: Hardianti Hardianti , Irmansyah Benny 
Published: February 2024

During the COVID-19 pandemic, virtual learning has been applied in the field of education until now. Virtual learning is a new method of learning that certainly provides significant impacts and challenges in English language learning. The impact of virtual learning certainly facilitates the interaction between teachers and students in English classes. As online learning environments become increasingly prevalent, understanding the nuanced social interactions in these settings is crucial. However, virtual learning also provides obstacles in the teaching and learning process. This research employed a virtual ethnographic approach to investigate the dynamics of social interaction within virtual English classes at Esa Unggul University. Through an ethnographic lens, this study delves into the multifaceted nature of interactions among students and lecturers in virtual English classes. Utilizing qualitative data collection methods such as classroom observation, questionnaires, interviews, and analysis of digital communication, shaping social dynamics in the virtual classroom. The findings illuminate the complexities of social interaction, highlighting the role of technology, communication styles, and cultural influences in shaping virtual learning environments. This study's insights contribute to a deeper comprehension of social dynamics in online educational settings and offer valuable implications for optimizing engagement and fostering meaningful interactions in virtual English classes.
Thematische Schwerpunkte und Denkfiguren des legendarischen Erzählens
Authors: Sliepen Volker 
Published: February 2024

ZusammenfassungDie Analyse der frühchristlichen und mittelalterlichen legendarischen Texte hatte das Ziel, zu geistig-kulturellen Kategorien und Fragestellungen durchzudringen, die an der Schnittstelle von Philologie, Anthropologie, Theologie und Philosophie angesiedelt sind und „das Verhältnis zwischen Gott und der Welt sowie die Rolle des Menschen in der Welt im Kern [berühren].“
A negative emotional state impairs individuals’ ability to filter distractors from working memory: an ERP study
Authors: Ye Chaoxiong , Liu Ruyi , Guo Lijing , Zhao Guoying , Liu Qiang 
Published: February 2024

AbstractCapacity-limited visual working memory (VWM) requires that individuals have sufficient memory space and the ability to filter distractors. Negative emotional states are known to impact VWM storage, yet their influence on distractor filtering within VWM remains underexplored. We conducted direct neural measurement of participants (n = 56) who conducted a lateralized change detection task with distractors, while manipulating the emotional state by presenting neutral or negative images before each trial. We found a detrimental effect of distractors on memory accuracy under both neutral and negative emotional states. Using the event-related potential (ERP) component, contralateral delay activity (CDA; sensitive to VWM load), to observe the VWM load in each condition, we found that in the neutral state, the participants showed significantly higher late CDA amplitudes when remembering 4 targets compared with 2 targets and 2 targets with 2 distractors but no significant difference when remembering 2 targets compared with 2 targets with 2 distractors. In the negative state, no significant CDA amplitude differences were evident when remembering 4 targets and 2 targets, but CDA was significantly higher when remembering 2 targets with 2 distractors compared with 2 targets. These results suggest that the maximum number of items participants could store in VWM was lower under negative emotional states than under neutral emotional states. Importantly, the participants could filter out distractors when in a neutral emotional state but not in a negative emotional state, indicating that negative emotional states impair their ability to filter out distractors in VWM.
TOI-4201: An Early M Dwarf Hosting a Massive Transiting Jupiter Stretching Theories of Core Accretion*
Authors: Delamer Megan , Kanodia Shubham , Cañas Caleb I. , Müller Simon , Helled Ravit , Lin Andrea S. J. , Libby-Roberts Jessica E. , Gupta Arvind F. , Mahadevan Suvrath , Teske Johanna , Butler R. Paul , Yee Samuel W. , Crane Jeffrey D. , Shectman Stephen , Osip David , Beletsky Yuri , Monson Andrew , Hebb Leslie , Powers Luke C. , Wisniewski John P. , Alvarado-Montes Jaime A. , Bender Chad F. , Dong Jiayin , Han Te , Ninan Joe P. , Robertson Paul , Roy Arpita , Schwab Christian , Stefánsson Guđmundur , Wright Jason T. 
Published: February 2024

Abstract
We confirm TOI-4201 b as a transiting Jovian-mass planet orbiting an early M dwarf discovered by the Transiting Exoplanet Survey Satellite. Using ground-based photometry and precise radial velocities from NEID and the Planet Finder Spectrograph, we measure a planet mass of

2.59

−
0.06

+
0.07

M
J, making this one of the most massive planets transiting an M dwarf. The planet is ∼0.4% of the mass of its 0.63 M
⊙ host and may have a heavy-element mass comparable to the total dust mass contained in a typical class II disk. TOI-4201 b stretches our understanding of core accretion during the protoplanetary phase and the disk mass budget, necessitating giant planet formation to take place either much earlier in the disk lifetime or perhaps through alternative mechanisms like gravitational instability.