bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Early Qing Compilation of the Ming History in Manchu: The Contexts, Contents, and Significance of the Ming gurun i suduri
Authors: Yin Shoufu 
Published: December 2023

Abstract
The Qing court produced an extensive history of the Ming empire in the Manchu language, which has survived in manuscript form in the Palace Museum under the title Ming gurun i suduri (History of the Ming State). Based on a close reading of this manuscript and scrutiny of related archival documents, this article elaborates on three observations. First, the Ming gurun i suduri resulted from the earliest stage (1645–1669) of the Qing compilation of the Ming history. With a primary focus on producing a chronicle in Manchu, it exemplifies the mid-seventeenth-century development of Inner Asian historiography. Second, it recounts Ming history by juxtaposing and connecting translated extracts from the Ming shilu 明實錄 (Ming Veritable Records) whenever it exists. This approach that combines compiling and translating, in effect, offers a reassessment of key political events and figures. Third, in light of the Ming gurun i suduri thus contextualized, the 1739 Ming shi 明史 (Ming History) is best seen as a product of a century-long history of negotiation (1645–1739) during which the ideological agenda and intellectual achievements of the early Qing court gradually sank into oblivion.
Learning and Teaching with Outdoor STEAM Education
Authors: Haas Ben , Kreis Yves , Jablonski Simone , Cahyono Adi Nur 
Published: December 2023

Abstract
In this special issue, the topic of Outdoor Education related to an integrated STEM approach is taken into consideration. Three articles focus on theoretical background and practical investigations of education outside the classroom. The issue aims at contributing to further research on the topic and providing an overview of activities that strengthen the link between the STEM disciplines and the students’ environment.
Out of Doors and Outdoors
Authors: Békési Brigitta , Houghton Tony , Ulbrich Eva , Lavicza Zsolt 
Published: December 2023

Abstract
This study examines STEAM learning outside the classroom: necessary preparations, how students cope with ‘mobile learning’, and how motivation changes while working on problem-based STEAM tasks. Further, the authors provide examples of tasks without and with technology support, and compare two mobile applications, Actionbound and MathCityMap, supporting outdoor math trails. The study started in 2017 by collecting data based on observations about students’ motivation and views on outdoor mathematics and has been carried on ever since by collecting data mainly from lower secondary school classes involving 90 students. As the authors also gave workshops on STEAM to pre-service teachers, they questioned the participants (a group of 13) about their experiences with STEAM, technology, and outdoor mathematics. The authors found that ‘mobile learning’ and STEAM tasks enhance students’ motivations, however, pre-service teachers have little experience and may need more support during their studies to implement STEAM and technology, hence the authors aim to design such courses.
Multi-scale analysis of styrene butadiene latex modified PVA fiber concrete
Authors: Feng Yong , Feng Jingjie , Chen Wang , Zhao Chen , Li Zehua 
Published: December 2023

Polyvinyl alcohol (PVA) concrete is a new green building material. In order to make it more widely used, this study used butylbenzene emulsion (SBL) to modify PVA fiber concrete. The enhancement mechanism of SBL on the PVA/cement interface was systematically investigated at multiple scales, including macroscopic mechanical properties, microstructural characteristics, nano-interface interactions. On a macro scale, the addition of SBL and PVA fibers can significantly improve the shear strength and flexural strength of composite concrete at 7 and 28 days, and SBL can make up for the decrease in compressive strength caused by PVA. On a micro scale, the corresponding polymer cement concrete was tested by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). It was observed that some gels and polymers filled the interfacial gap and effectively repaired the interfacial defects. The SBL brought the two interfaces closer together and described its bonding effect at the micro-interface. On the nano scale, SBL/PVA/C-S-H is modeled by molecular dynamics method. Binding energy, Relative concentrations, Radial distribution function, Mean-square displacement and Time correlation function were analyzed and calculated. The results show that SBL reduces the interfacial effect, enhances the interfacial hydrogen bond, van der Waals interaction, Ca-H coordination bond and stability, improves the interfacial adhesion, and further enhances the weak interfacial bond between organic polymer (PVA) and inorganic silicate (C-S-H).
Analysis of China’s Environmental Regulations and Corresponding Differences for Green Steel Industry Development
Authors: Islam Md. Ziaul 
Published: December 2023

In the last 20 years, China’s steel production has proliferated, leading to increased environmental damage by releasing 574,000 tons of sulfur dioxide (SO2), 1,114,000 tons of nitrogen oxide (NOx), and 897,000 tons of particulate matter (PM) in 2020; therefore, the country is now struggling to reduce carbon emissions and tackle climate change because of the conflicting demands of economic growth and environmental protection. Given the global emphasis on decarbonization and sustainable production, China has prioritized achieving peak carbon emissions of 30% by 2030 and carbon neutrality by 2060. Likewise, China’s steel industry is progressing toward attaining the maximum carbon dioxide (CO2) emissions by 2025. This study reveals that despite a 321 Mt increase in global energy-related CO2 emissions in 2022, CO2 emissions in China experienced a decline of 230 Mt during the same period. Notwithstanding enacting several pertinent statutes and directives, China’s iron and steel sector has not advanced substantially.
Investigation on the time/frequency domain prediction model of radiation noise based on the source map
Authors: Tan Xiao-ming , Yang Zhi-gang 
Published: December 2023

The main exterior noise sources of the high-speed train CRH380AM, such as pantograph and bogie, are studied by using the field test sound imaging data, and the equivalent point source spectrums are obtained here. Then, the prediction model of the exterior train noise is presented by using the moving point sound source radiation model in the time/frequency domain. The correctness and effectiveness of the model are verified by the field test data. The radiation contribution of local noise sources is analyzed by using this model, and the following conclusions are obtained: The largest noise sources are in the bogie areas, which provide the radiation contribution rate of about 80% when the train speed is above 300 km/h. The variation of the maximum radiation noise level can be ignored when the train formation or the pantograph lifting position is changed. The model can evaluate the radiated noise of similar vehicles quickly and accurately, which provides technical reference for acoustic optimization design of high-speed train.
“Play How We Practice”: A Residency Program's Snapshot of Pediatric Resident Perspectives on Education During the COVID-19 Pandemic
Authors: Williams Amanda , Schlueter Derika , Aprile Justen , Patterson Kelly , Miller Jennifer , Shedlock Aaron R. 
Published: December 2023

OBJECTIVES Our objective was to understand the perspectives of current and recently graduated pediatric residents concerning the impact of the COVID-19 pandemic, and subsequent curriculum changes, to their education. INTRODUCTION Residency programs have experienced unprecedented alterations to education in the form of changing expectations, schedules, and opportunities during the COVID-19 pandemic. Little is known regarding resident perceptions of how these changes impact their education and ultimate career preparation. METHODS An anonymous and voluntary electronic IRB exempt survey was sent to pediatric residents at a mid-sized residency program in the mid-Atlantic in August of 2020. This cross-sectional study survey consisted of a series of multiple choice questions with optional short answer responses. RESULTS Twenty-two pediatric residents across all training years completed the survey for a response rate of 36%. The majority of residents, 59.1%, were interested in directly caring for COVID + patients; however, the minority (36%) felt prepared to care for COVID + patients. Most residents (63%) responded that graduate medical education programs should not have authority to exclude residents from taking care of patients with certain diagnoses and 95% of respondents indicated that they would prefer an opt out system instead. CONCLUSION The majority of resident respondents had a strong interest in caring for COVID + patients and report that they value frequent updates from program leadership to guide their patient care. Residents also overwhelmingly support an opt out system when caring for future patients with particular infectious diagnoses rather than a mandated exclusion approach.
Cardiac Evaluation and its Correlation with Volume Status in Maintenance Hemodialysis Patients
Authors: Bhattacharyya Sutanay , Mahapatra Himanshu Sekhar , Pursnani Lalit , Kumar Muthu , Gupta Vipul , Tarachandani Rajesh , Chaudhary Preeti 
Published: December 2023

Introduction: Fluid overload (FO) in hemodialysis (HD) patients can result in increase in left atrial volume (LAV) and left ventricular mass (LVM). Here, we correlated volume status with cardiac outcome in these patients over a period of 6 months. Methodology: Consecutive clinically euvolumic end stage renal disease (ESRD) patients on thrice weekly maintenance hemodialysis (MHD) for at least 6 months were included. Inferior vena cava (IVC) Collapsibility Index of ≤40% by IVC or B-Line score of ≥15 by lung ultrasound (LUS) or over hydration/extracellular water (OH/ECW) by bioimpedence spectroscopy (BIS) ≥15% were defined as FO. A cut-off of left ventricular mass index (LVMI) ≥115 gm/m2 and LAV index (LAVI) ≥34 mL/m2 on echocardiography were used for defining left ventricular hypertrophy (LVH) and left atrial dilatation (LAD), respectively. The diagnostic value of LUS for OH, considering BIS as the gold standard and correlation between LVMI and LAVI with OH/ECW and LUS score was studied. Results: Among 100 MHD patients, 29% had OH at baseline. Baseline FO was significantly associated with LAD but not LVH. The specificity of LUS in diagnosing FO at 3rd and 6th months was 98% and 95.1%, respectively. OH/ECW on BIS showed a correlation with both LAVI at baseline ( p-value of .03, R2 0.71). B line score determined by LUS did not show a correlation with LAVI at baseline ( p-value of .07, R2 0.49). Conclusion: Routine ultrasound use in HD unit for determining OH and echocardiography screening for LAD would assess and reduce early cardiovascular events.
Utility or futility? A contemporary approach to allogeneic hematopoietic cell transplantation for TP53-mutated MDS/AML
Authors: Nawas Mariam T. , Kosuri Satyajit 
Published: December 2023

Abstract
TP 53-mutated myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are among the most lethal malignancies, characterized by dismal outcomes with currently available therapies. Allogeneic hematopoietic cell transplantation (allo-HCT) is widely thought to be the only treatment option to offer durable disease control. However, outcomes with allo-HCT in this context are quite poor, calling into question the utility of transplantation. In this review, we summarize the latest data on allo-HCT outcomes in this subgroup, evaluating the limitations of available evidence; we review the molecular heterogeneity of this disease, delineating outcomes based on distinct biological features to aid in patient selection; and we critically examine whether allo-HCT should be routinely applied in this disease on the basis of currently available data. We propose that the exceptionally poor outcomes of patients with TP53-mutated MDS/AML with biallelic loss and/or adverse-risk cytogenetics should motivate randomized-controlled trials of HCT vs non-HCT to determine whether transplantation can prolong survival and/or positively impact other clinically relevant outcomes such as patient-reported outcomes or healthcare resource utilization in this disease subset. Without dedicated prospective randomized trials, selecting who may actually derive benefit from allo-HCT for TP53-mutated MDS/AML can be described as ambiguous guesswork and must be carefully contemplated.
Genetically corrected RAG2-SCID human hematopoietic stem cells restore V(D)J-recombinase and rescue lymphoid deficiency
Authors: Pavel-Dinu Mara , Gardner Cameron L. , Nakauchi Yusuke , Kawai Tomoki , Delmonte Ottavia M. , Palterer Boaz , Bosticardo Marita , Pala Francesca , Viel Sebastien , Malech Harry L. , Ghanim Hana Y. , Bode Nicole M. , Kurgan Gavin L. , Detweiler Angela M. , Vakulskas Christopher A. , Neff Norma F. , Sheikali Adam , Menezes Sherah T. , Chrobok Jade , Hernández González Elaine M. , Majeti Ravindra , Notarangelo Luigi D. , Porteus Matthew H. 
Published: December 2023

Abstract
Recombination-activating genes (RAG1 and RAG2) are critical for lymphoid cell development and function by initiating the variable (V), diversity (D), and joining (J) (V(D)J)-recombination process to generate polyclonal lymphocytes with broad antigen specificity. The clinical manifestations of defective RAG1/2 genes range from immune dysregulation to severe combined immunodeficiencies (SCIDs), causing life-threatening infections and death early in life without hematopoietic cell transplantation (HCT). Despite improvements, haploidentical HCT without myeloablative conditioning carries a high risk of graft failure and incomplete immune reconstitution. The RAG complex is only expressed during the G0-G1 phase of the cell cycle in the early stages of T- and B-cell development, underscoring that a direct gene correction might capture the precise temporal expression of the endogenous gene. Here, we report a feasibility study using the CRISPR/Cas9-based “universal gene-correction” approach for the RAG2 locus in human hematopoietic stem/progenitor cells (HSPCs) from healthy donors and RAG2-SCID patient. V(D)J-recombinase activity was restored after gene correction of RAG2-SCID-derived HSPCs, resulting in the development of T-cell receptor (TCR) αβ and γδ CD3+ cells and single-positive CD4+ and CD8+ lymphocytes. TCR repertoire analysis indicated a normal distribution of CDR3 length and preserved usage of the distal TRAV genes. We confirmed the in vivo rescue of B-cell development with normal immunoglobulin M surface expression and a significant decrease in CD56bright natural killer cells. Together, we provide specificity, toxicity, and efficacy data supporting the development of a gene-correction therapy to benefit RAG2-deficient patients.
Bacterial colonisation of the airway in neonates and risk of asthma and allergy until age 18 years
Authors: Sunde Rikke Bjersand , Thorsen Jonathan , Kim Min , Schoos Ann-Marie Malby , Stokholm Jakob , Bønnelykke Klaus , Bisgaard Hans , Chawes Bo 
Published: December 2023

BackgroundWe previously showed an association between neonatal bacterial airway colonisation and increased risk of persistent wheeze/asthma until age 5 years. Here, we study the association with persistent wheeze/asthma and allergy-related traits until age 18 years.MethodsWe investigated the association between airway colonisation withStreptococcus pneumoniae,Moraxella catarrhalisand/orHaemophilus influenzaein 1-month-old neonates from the COPSAC2000mother–child cohort and the development of persistent wheeze/asthma and allergy-related traits longitudinally until age 18 years using generalised estimating equations. Replication was sought in the similarly designed COPSAC2010cohort of 700 children.ResultsNeonatal airway colonisation was present in 66 (21%) out of 319 children and was associated with a 4-fold increased risk of persistent wheeze/asthma (adjusted OR 4.01 (95% CI 1.76–9.12); p<0.001) until age 7 years, but not from age 7 to 18 years. Replication in the COPSAC2010cohort showed similar results using 16S data. Colonisation was associated with an increased number of exacerbations (adjusted incidence rate ratio 3.20 (95% CI 1.38–7.44); p<0.01) until age 7 years, but not from age 7 to 18 years. Colonisation was associated with increased levels of blood eosinophils (adjusted geometric mean ratio 1.24 (95% CI 1.06–1.44); p<0.01) and tumour necrosis factor (TNF)-α (adjusted geometric mean ratio 1.09 (95% CI 1.02–1.16); p=0.01) until age 12 years. There were no associations with lung function, bronchial reactivity, fractional exhaled nitric oxide, allergic sensitisation, total IgE or atopic dermatitis up to age 18 years.ConclusionsNeonatal airway colonisation was associated with early-onset persistent wheeze/asthma, exacerbations, elevated blood eosinophils and elevated TNF-α in blood, most prominent in early childhood, thereafter diminishing and no longer evident by age 18 years.
Twnbiome: a public database of the healthy Taiwanese gut microbiome
Authors: Chattopadhyay Amrita , Lee Chien-Yueh , Lee Ya-Chin , Liu Chiang-Lin , Chen Hsin-Kuang , Li Yung-Hua , Lai Liang-Chuan , Tsai Mong-Hsun , Ni Yen-Hsuan , Chiu Han-Mo , Lu Tzu-Pin , Chuang Eric Y. 
Published: December 2023

AbstractWith new advances in next generation sequencing (NGS) technology at reduced costs, research on bacterial genomes in the environment has become affordable. Compared to traditional methods, NGS provides high-throughput sequencing reads and the ability to identify many species in the microbiome that were previously unknown. Numerous bioinformatics tools and algorithms have been developed to conduct such analyses. However, in order to obtain biologically meaningful results, the researcher must select the proper tools and combine them to construct an efficient pipeline. This complex procedure may include tens of tools, each of which require correct parameter settings. Furthermore, an NGS data analysis involves multiple series of command-line tools and requires extensive computational resources, which imposes a high barrier for biologists and clinicians to conduct NGS analysis and even interpret their own data. Therefore, we established a public gut microbiome database, which we call Twnbiome, created using healthy subjects from Taiwan, with the goal of enabling microbiota research for the Taiwanese population. Twnbiome provides users with a baseline gut microbiome panel from a healthy Taiwanese cohort, which can be utilized as a reference for conducting case-control studies for a variety of diseases. It is an interactive, informative, and user-friendly database. Twnbiome additionally offers an analysis pipeline, where users can upload their data and download analyzed results. Twnbiome offers an online database which non-bioinformatics users such as clinicians and doctors can not only utilize to access a control set of data, but also analyze raw data with a few easy clicks. All results are customizable with ready-made plots and easily downloadable tables. Database URL: http://twnbiome.cgm.ntu.edu.tw/.
Left atrial Thrombus formation after discontinuation of anticoagulation in patient with severe bioprosthetic mitral stenosis
Authors: King Ryan C. , Mathew Tobin , Whang Stella , Premyodhin Ned , Patel Pranav 
Published: December 2023

Abstract
Background
Mitral valve stenosis can be a highly symptomatic condition with significant complications if left untreated. In such cases, mitral valve replacement with a bioprosthetic or mechanical valve may be a viable solution to prevent progressive disease. Current guidelines do not recommend continued anticoagulation beyond 6 months for patients who have undergone bioprosthetic valve replacement without a separate indication for anticoagulation. With this case discussion we aim to 1) Review the current indications for anticoagulation for bioprosthetic mitral valves in patients without atrial fibrillation and 2) Discuss the constellation of comorbidities that may affect the decision to begin anticoagulation therapy.

Case presentation
We present a case describing a 55-year-old male with end-stage renal disease, coronary artery disease with coronary artery bypass graft surgery, and bioprosthetic mitral valve replacement 2 years prior with rapid degeneration of the replaced valve and on warfarin without a clear indication for anticoagulation. The patient was admitted for symptomatic, severe mitral stenosis and consideration of transcatheter mitral valve-in-valve replacement. During hospital admission, warfarin was discontinued and replaced with prophylactic anticoagulation. However, 8 days after warfarin cessation an intraoperative transesophageal echocardiography revealed a newly developed large left atrial thrombus leading to cancellation of the planned operation.

Conclusions
This patient developed a left atrial thrombus after discontinuing warfarin in the setting of rapidly deteriorating bioprosthetic valve stenosis and vascular comorbidities. The decision to discontinue warfarin was made in concordance with current guidelines, which do not indicate systemic anticoagulation post 3–6 months after bioprosthetic valve replacement without separate indication for anticoagulation. This case identifies the need to investigate rebound hypercoagulability and further risk stratify comorbidities which may independently increase the risk of clot formation in the setting of severe mitral valve stenosis.
Digital solutions for decision support in general practice – a rapid review focused on systems developed for the universal healthcare setting in Denmark
Authors: Clausen Anne , Christensen Emilie Rosenfeldt , Jakobsen Pernille Ravn , Søndergaard Jens , Abrahamsen Bo , Rubin Katrine Hass 
Published: December 2023

Abstract
Background
Digital health solutions hold the potential for supporting general practitioners in decision-making, and include telemedicine systems, decision support systems, patient apps, wearables, fitness trackers, etc.

Aim
This review aimed to identify digital solutions developed for, tested, or implemented in general practice to support the decisions of GPs in disease detection and management, using Denmark as an example country of a universal healthcare setting.

Methods
This study was conducted as a rapid review. The primary search included a database search conducted in Embase and MEDLINE. The supplementary search was conducted in Infomedia and additionally included a snowball search in reference lists and citations of key articles identified in the database search. Titles were screened by two reviewers.

Results
The review included 15 studies as key articles describing a total of 13 digital solutions for decision support in general practice in Denmark. 1.123 titles were identified through the database search and 240 titles were identified through the supplementary and snowball search.

Conclusions
The review identified 13 digital solutions for decision support in general practice in a Danish healthcare setting aimed at detection and/or management of cancer, COPD, type 2 diabetes, depression, liver disease or multiple lifestyle-related diseases. Implementation aspects should be reported more transparently in future publications to enable applicability of digital solutions as decision support to aid general practitioners in disease detection and management.