bluuebunny/crossref_metadata_2025_split huggingface dataset:
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism
Authors: Mastraccio Kate E , Huaman Celeste , Coggins Si'Ana A , Clouse Caitlyn , Rader Madeline , Yan Lianying , Mandal Pratyusha , Hussain Imran , Ahmed Anwar E , Ho Trung , Feasley Austin , Vu Bang K , Smith Ina L , Markotter Wanda , Weir Dawn L , Laing Eric D , Broder Christopher C , Schaefer Brian C 
Published: September 2023

AbstractInfections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus accesses the central nervous system (CNS) and causes disease signs. Current immunotherapies are thus focused on the early, pre‐symptomatic stage of disease, with the goal of peripheral neutralization of virus to prevent CNS infection. Here, we evaluated the therapeutic efficacy of F11, an anti‐lyssavirus human monoclonal antibody (mAb), on established lyssavirus infections. We show that a single dose of F11 limits viral load in the brain and reverses disease signs following infection with a lethal dose of lyssavirus, even when administered after initiation of robust virus replication in the CNS. Importantly, we found that F11‐dependent neutralization is not sufficient to protect animals from mortality, and a CD4 T cell‐dependent adaptive immune response is required for successful control of infection. F11 significantly changes the spectrum of leukocyte populations in the brain, and the FcRγ‐binding function of F11 contributes to therapeutic efficacy. Thus, mAb therapy can drive potent neutralization‐independent T cell‐mediated effects, even against an established CNS infection by a lethal neurotropic virus.
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma
Authors: Ramesh Vignesh , Gollavilli Paradesi Naidu , Pinna Luisa , Siddiqui Mohammad Aarif , Turtos Adriana Martinez , Napoli Francesca , Antonelli Yasmin , Leal‐Egaña Aldo , Havelund Jesper Foged , Jakobsen Simon Toftholm , Boiteux Elisa Le , Volante Marco , Færgeman Nils Joakim , Jensen Ole N , Siersbæk Rasmus , Somyajit Kumar , Ceppi Paolo 
Published: September 2023

AbstractThe epithelial‐to‐mesenchymal transition (EMT) plays a central role in the development of cancer metastasis and resistance to chemotherapy. However, its pharmacological treatment remains challenging. Here, we used an EMT‐focused integrative functional genomic approach and identified an inverse association between short‐chain fatty acids (propionate and butanoate) and EMT in non‐small cell lung cancer (NSCLC) patients. Remarkably, treatment with propionate in vitro reinforced the epithelial transcriptional program promoting cell‐to‐cell contact and cell adhesion, while reducing the aggressive and chemo‐resistant EMT phenotype in lung cancer cell lines. Propionate treatment also decreased the metastatic potential and limited lymph node spread in both nude mice and a genetic NSCLC mouse model. Further analysis revealed that chromatin remodeling through H3K27 acetylation (mediated by p300) is the mechanism underlying the shift toward an epithelial state upon propionate treatment. The results suggest that propionate administration has therapeutic potential in reducing NSCLC aggressiveness and warrants further clinical testing.
Single cell RNA sequencing sheds light on infiltrating T cells in idiopathic inflammatory myopathies
Authors: Yazdani Momina , Mach Lukas , Noseda Michela 
Published: September 2023

Idiopathic inflammatory myopathies (IIM), also referred to as “myositis,” are a group of heterogeneous autoimmune disorders characterised by muscle weakness, atrophy and progressive reduced mobility (Lundberg et al, 2021). IIM represent a significant health burden in adult populations, affecting individuals at a mean age of 50 with an estimated prevalence of 2.9–34 per 100,000 (Dobloug et al, 2015; Svensson et al, 2017). IIM encompass several subtypes including dermatomyositis, immune‐mediated necrotising myopathy, inclusion‐body myositis, antisynthetase syndrome and polymyositis, which are characterised by specific clinical features, histopathological findings and autoantibody status (Pinal‐Fernandez et al, 2020).
Sertoliform endometrioid carcinoma of the right ovary
Authors: Alali Mohammad , Hajji Sulaiman , Aljenaee Khalid 
Published: September 2023

Summary
Endometrioid carcinomas of the ovary are a subtype of epithelial ovarian tumors, with sertoliform endometrioid carcinomas being a rare variant. We report a case of a previously healthy premenopausal woman presenting with androgenic symptoms in the form of hirsutism and male pattern alopecia. On further testing, she was found to have high levels of luteinizing hormone and total testosterone levels, and imaging revealed a large pelvic abdominal mass in the right ovary. She underwent total hysterectomy with bilateral salpingo-oophorectomy. Microscopy and histopathology confirmed the diagnosis of sertoliform endometrioid carcinoma. Her symptoms improved significantly on follow-up. Androgenic tumors might not be common in premenopausal women; however, it is important to maintain a high level of suspicion in patients presenting with virilizing symptoms especially of rapid progression.

Learning points

Our 47-year-old patient presented with virilizing symptoms that were rapidly progressing, which raises the suspicion of an underlying androgen secreting neoplasm.

Sertoliform endometrioid carcinoma (SEC) is an extremely rare variant of endometrioid carcinomas and tend to present at an earlier stage as compared to most endometrioid carcinomas of the ovary.

Recognition of SEC in virilizing patients is important as it is a well-differentiated, low-grade malignancy with a good prognosis when confined to the ovary.
Usefulness of second 131I treatment in biochemical persistent differentiated thyroid cancer patients
Authors: Gambale Carla , Prete Alessandro , Contartese Lea , Torregrossa Liborio , Bianchi Francesca , Molinaro Eleonora , Materazzi Gabriele , Elisei Rossella , Matrone Antonio 
Published: September 2023

Background
Second 131I treatment is commonly performed in clinical practice in patients with differentiated thyroid cancer and biochemical incomplete or indeterminate response (BiR/InR) after initial treatment.

Objective
The objective of the is study is to evaluate the clinical impact of the second 131I treatment in BiR/InR patients and analyze the predictive factors for structural incomplete response (SiR).

Patients and methods
One hundred fifty-three BiR/InR patients after initial treatment who received a second 131I treatment were included in the study. The clinical response in a short- and medium- long-term follow-up was evaluated.

Results
After the second 131I treatment (median 8 months), 11.8% patients showed excellent response (ER), 17% SiR, while BiR/InR persisted in 71.2%. Less than half (38.5%) of SiR patients had radioiodine-avid metastases. Patients who, following the second 131I treatment, experienced SiR had larger tumor size and more frequently aggressive histology and vascular invasion than those experienced BiR/InR and ER. Also, the median values of thyroglobulin on levothyroxine therapy (LT4-Tg), Tg peak after recombinant human TSH stimulation (rhTSH-Tg) and thyroglobulin antibodies (TgAb) were significantly higher in patients who developed SiR. At last evaluation (median: 9.9 years), BiR/InR persisted in 57.5%, while 26.2% and 16.3% of the patients showed ER and SiR, respectively. About half of BiR/InR patients (71/153 (46.4%)) received further treatments after the second 131I treatment.

Conclusions
Radioiodine-avid metastatic disease detected by the second 131I is an infrequent finding in patients with BiR/InR after initial treatment. However, specific pathologic and biochemical features allow to better identify those cases with higher probability of developing SiR, thus improving the clinical effectiveness of performing a second 131I treatment.
External Validity and Consistency over Time of Patient Segmentation Based on Disease Acceptance and Perceived Control in Inflammatory Bowel Disease
Authors: Van Erp Liselot Willemijn , Thomas Pepijn W.A. , Groenen Marcel J.M. , Bloem Sjaak , Russel Maurice G.V.M. , Römkens Tessa E.H. , Wahab Peter J. 
Published: September 2023

Background and Aims: The patient segmentation model based on disease acceptance and perceived control may guide personalized care in inflammatory bowel disease (IBD). We aimed to investigate the external validity of the segmentation model and its consistency over time.
Methods: This is a multicenter longitudinal cohort study of adult IBD patients with questionnaires on disease acceptance and perceived control (6-items, 7-point Likert scale) and health-related quality of life (HRQoL) (Short IBD questionnaire, range 10-70). Segments were created based on mean scores (cut-off>5): (I) high acceptance, high control; (II) high acceptance, low control; (III) low acceptance, high control and; (IV) low acceptance, low control.
Results: The external validation cohort included 921 IBD patients. The acceptance and control scale were unidimensional and internally consistent. Segments differed significantly in gender, disease duration, IBD medication and clinical disease activity. High acceptance and/or high control were significantly associated with a higher HRQoL compared with low acceptance and low control (i.e., segment IV) (Beta (95%CI) segment I=11.7 (10.4-13.1), segment II=9.3 (7.7-10.9) and segment III=3.8 (1.6-6.0), p≤0.001). The follow-up cohort included 783 patients: 58% remained in the same segment while 42% differed in segment over time. Changes in segment were positively correlated with changes in HRQoL over time (Spearman rho 0.38, p<0.001).
Conclusions: The patient segmentation model based on disease acceptance and perceived control was externally valid and showed consistency over time. The different segments were independently associated with HRQoL. Future interventions should aim to personalize care based on segments and improve disease acceptance and perceived control of IBD patients.
Assessment of mechanical and durability performance of silica fume and metakaolin as cementitious materials in high-performance concrete
Authors: Sankar B. , Ramadoss P. 
Published: September 2023

AbstractThe present study aims to determine the effects of blending cementitious materials on the mechanical and durability properties of high-performance concrete (HPC). Densified silica fume and fine-grounded metakaolin are used as supplementary cementitious materials (SCMs). A total of 16 mixes containing both binary and ternary blending of SCMs were chosen for w/b ratios of 0.4 and 0.3 respectively. The hardened properties tested for the HPC mixes were compressive strength at 7, 28, and 90 days, flexural strength at 28 days, and modulus of elasticity at 28 days. Maximum strength gains up to 15%, 38%, and 23% for compression, flexure, and elastic modulus were observed in ternary mixes compared to binary mixes. Stress-strain behaviour of ternary mixes indicates increased tolerance of stress for the least amount of strain in the specimens. Based on the experimental results, empirical relations were developed and checked with the existing codes and by earlier researchers. The durability properties tested for HPC were water absorption at 28 days, acid attack, and sulphate attack at 28, 56, and 90 days. Ternary mixes improved the pore structure of HPC, resulting in a 56% reduction in water absorption and a 34% reduction in compressive strength loss due to immersion in 5% H2SO4 at 90 days. The findings of the study endorse that ternary blending of SF and MK can improve the engineering properties of HPC, and a mix containing SF 10% and MK 10% is recommended for the best results.
Attention, response inhibition, and hoarding: A neuropsychological examination
Authors: Norberg Melissa M. , Meares Susanne , Stevenson Richard J. , Tame Jack , Wong Gary , Aldrich Paul , Olivier Jake 
Published: September 2023

AbstractBackground and aimsThe prominent cognitive-behavioral model of hoarding posits that information processing deficits contribute to hoarding disorder. Although individuals with hoarding symptoms consistently self-report attentional and impulsivity difficulties, neuropsychological tests have inconsistently identified impairments. These mixed findings may be the result of using different neuropsychological tests, tests with poor psychometric properties, and/or testing individuals in a context that drastically differs from their own homes.MethodsOne hundred twenty-three participants (hoarding = 63; control = 60) completed neuropsychological tests of sustained attention, focused attention, and response inhibition in cluttered and tidy environments in a counterbalanced order.ResultsHoarding participants demonstrated poorer sustained attention and response inhibition than the control group (CPT-3 Omission and VST scores) and poorer response inhibition in the cluttered environment than when in the tidy environment (VST scores). CPT-3 Detectability and Commission scores also indicated that hoarding participants had greater difficulty sustaining attention and inhibiting responses than the control group; however, these effect sizes were just below the lowest practically meaningful magnitude. Posthoc exploratory analyses demonstrated that fewer than one-third of hoarding participants demonstrated sustained attention and response inhibition difficulties and that these participants reported greater hoarding severity and greater distress in the cluttered room.Discussion and conclusionsGiven these findings and other studies showing that attentional difficulties may be a transdiagnostic factor for psychopathology, future studies will want to explore whether greater sustained attention and response inhibition difficulties in real life contexts contribute to comorbidity and functional impairment in hoarding disorder.
Legal Support of Private Interest
Authors: Imekova M. P. 
Published: September 2023

There is no single point of view in legal science regarding the criteria for distinguishing public and private law. Moreover, there is no theory that would be recognized by most researchers. The reason lies in the fact that scientists in their works analyze public and private law in various aspects, in this regard, they identify such criteria of differentiation that cannot be universal.The paper considers public and private law from the standpoint of instrumental theory and define it as a system of legal means designed to satisfy public or private interests, respectively. The undoubted advantage of this theory is that it is not focused on the search for universal criteria for distinguishing public law from private law, but suggests focusing on legal means aimed at creating the conditions necessary to meet the diverse legal interests of legal subjects. It is proved that public and private law are an integral part of legal support. Legal support, depending on the purpose (the type of interest being satisfied — public or private), is proposed to be divided into two types: public law and private law. It is established that support of interests in private law differs from that one in public law in the following. It allows for the possibility of choosing or changing behaviors provided for by regulatory legal means through the manifestation of legal initiative on the part of legal entities, and the form of implementation of such an initiative is self-regulation. Legal relations on the implementation of legal means arising within the framework of private law enforcement of interests arise between legally equal subjects. Private law support of interests is designed to mediate such a type of activity as legal (legal realization) activity. Private law support of interests is characterized by such a type of legal regulation as permissive.
Democracia y socialismo en la era de la revolución
Authors: Granell Oteiza Xavier 
Published: September 2023

Reseña de Pablo Scotto, Los orígenes del derecho al trabajo en Francia (1789-1848), Centro de Estudios Políticos y Constitucionales, Madrid, 2021, 486 págs.
Enviado el (Submission Date): 27/12/2022Aceptado el (Acceptance Date): 17/01/2023
Our experience of cut throat injury at a tertiary care center during COVID-19 pandemic
Authors: Gupta Deepak K. , Yadav Ramraj , Yadav Shishupal , Chaudhary Ashvanee K. , Goyal Arpit , Singh Vishwambhar , Kumar Rajesh , Singh Garima , Sinha Ankita 
Published: September 2023

Background: Cut throat injury is a least commonly attempted method of suicide or homicide. Neck injury may be suicidal, homicidal or accidental depending upon the etiology. Hesitation mark around the wound is favor of suicidal attempt and without hesitation mark is a rare possibility of suicidal attempt.
Methods: This is a retrospective study carried out over period of one year, between April 2020 to March 2021, in a tertiary care center of north central India, during Covid-19 pandemic before the second wave.
Results: Total 37 cases were attended; incidence was more common in male than female (34:3). Most commonly involved age group was 21 to 30 years, most of the patients belonged to rural background and manual workers. Homicide was the most common cause of injury and mostly under the influence of alcohol.
Conclusions: Young males belonging to lower socioeconomic status and rural background were most common victims of cut throat injury in our study, homicide being the most common causative factor. Life of the patients can be saved with less morbidity and mortality by the means of good triage management and early intervention.
Consenso Latinoamericano de manejo de Sepsis en niños: Task Force de la Sociedad Latinoamericana de Cuidados Intensivos Pediátricos (SLACIP)
Authors: Fernández Sarmiento Jaime 
Published: September 2023

Objetivo. Realizar recomendaciones de consenso para el diagnóstico y el tratamiento de la sepsis en niños, en países de bajos y medianos ingresos con especial énfasis en América Latina.Métodos. Se conformó un panel de 27 expertos clínicos en el tratamiento de la sepsis pediátrica y dos metodólogos (que trabajan en países de América Latina y España) para estructurar 10 grupos nominales, cada uno de ellos coordinado por un miembro. Desde cada grupo se preparó un borrador de recomendaciones, basado en preguntas de trabajo previamente desarrolladas por coordinadores temáticos y metodológicos, las cuales posteriormente fueron votadas por el método Delphi, a través de una discusión virtual.Para la construcción del borrador de las recomendaciones se combinaron las opiniones de los expertos de los grupos con una rigurosa interpretación de la evidencia científica disponible, recolectada previamente por un bibliotecario especializado que incluyó algoritmos específicos para el Registro Especializado Cochrane, PubMed, Lilacs y Scopus, así como para las bases de datos OpenGrey para literatura gris. Se hizo especial énfasis en la búsqueda de investigaciones originales desarrolladas en países de bajos y medianos ingresos. Se incluyeron publicaciones en inglés, español y portugués. Posteriormente se generaron diez preguntas y utilizando el formato PICO se describió la Población (P), la Intervención (I), el Control (C) y los Resultados (O). Mediante reuniones virtuales realizadas entre febrero de 2020 y febrero de 2021, se revisaron las recomendaciones y sugerencias. Para que la recomendación fuera aceptada debía existir un consenso >75% en la votación. Si era <75% demostraba que no había consenso. Si la votación final estaba entre 75-79%, se hacía una sugerencia (discrecional o débil) a favor o en contra de la intervención. Si la votación era del 80% o más, se hacía una recomendación (fuertemente a favor o en contra de la intervención).Resultados. Al finalizar el Consenso se establecieron 62 recomendaciones para el diagnóstico y el tratamiento de la sepsis pediátrica en países de bajos y medianos ingresos, cubriendo tópicos que van desde la definición, el diagnóstico y los paquetes de medidas, hasta la discusión detallada de tratamientos específicos como los líquidos, los vasoactivos y las terapias adyuvantes. En general, 60 de ellas fueron recomendaciones sólidas; aunque 56 tuvieron un nivel bajo de evidencia.Conclusiones. Luego de realizar este ejercicio de consenso en nuestra región, donde la carga de la sepsis pediátrica es mayor que en los países de ingresos altos, es claro que aún se tiene poca evidencia proveniente de nuestras realidades. Consideramos importante desarrollar investigaciones que permitan conocer más a fondo las perspectivas en el diagnóstico y tratamiento de la sepsis pediátrica en América Latina. A pesar de sus limitaciones, este consenso es un importante paso para mejorar el enfoque de la sepsis pediátrica en nuestra región.
EGFR ve ALK mutasyonu taşiyan akciğer adenokarsinomlarinda platin bazli tedavi yanitlari ve hedefe yönelik tedavi ihtiyacinin arka plani
Authors: ERÇALIŞKAN Abdülkadir , TURNA Zeynep 
Published: September 2023

Amaç: EGFR ve EML-4/ALK mutasyonlu akciğer adenokarsinomu hastalarındaki deneyimlerimizi sunmak.
Gereç ve Yöntemler: 2580 hasta retrospektif olarak değerlendirildi. Çalışmaya yalnızca evre 4 akciğer adenokarsinomu olup ilk sıra en az 2 siklus platin bazlı rejimlerle tedavi edilen hastalar dahil edilmiştir.
Bulgular: Çalışmaya uygun 105 vakanın 14’ü EGFR, 4’ü EML-4/ALK mutant iken 75 vaka her iki mutasyonu da taşımıyordu. Medyan yaş ve tanı yaşı sırasıyla 61 ve 58.5 idi. %81'i erkekti ve %78'i sigara içiyordu. EGFR ve EML-4/ALK-mutant hastalar ağırlıklı olarak kadındı ve sigara içmiyordu (sırasıyla EGFR; p=0.025 ve 0.002, EML-4/ALK; p=0.003 ve 0.012). EML-4/ALK- mutant hastalar, bu mutasyonu taşımayanlara göre daha gençti (p=0,02) (Tablo 1). EGFR ekson-19, 20 ve 21 mutasyonları sırasıyla karaciğer, kemik ve plevral metastazlarla ilişkiliydi (sırasıyla p=0.046,
0.05 ve 0.035). Birinci basamak platin bazlı kemoterapiden sonra tam remisyon ve kısmi yanıt oranları sırasıyla %4,7 ve %24,6 idi. Eşzamanlı radyoterapi ve tanı sırasında kemik metastazlarının olmaması birinci basamak platin bazlı tedavi yanıtlarını etkileyen faktörlerdi (sırasıyla p=0.004 ve p=0.046). EGFR veya EML-4/ALK mutasyon durumu platin bazlı tedavi yanıtı açısından anlamlı fark göstermemiştir (sırasıyla p=0,933 ve 0,184). Medyan progresyonsuz sağkalım 10 ay iken eşzamanlı radyoterapi ve kemik metastazının tedavi yanıtı üzerinde gözlenen etkisi PFS sonuçlarına yansımamıştır (sırasıyla p=0,079 ve 0,285).
Sonuçlar: EGFR ve ALK mutasyonlarının varlığı, platin bazlı rejimlerin tedavi yanıtını etkilememektedir. EGFR ekson alt gruplarının metastaz noktaları ile ilişkisi araştırılması gereken bir nokta olarak saptanmıştır.