bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of molecular subtypes and diagnostic model in clear cell renal cell carcinoma based on collagen-related genes may predict the response of immunotherapy
Authors: Hong Yulong , Lv Zhengtong , Xing Zhuo , Xu Haozhe , Chand Harripersaud , Wang Jianxi , Li Yuan 
Published: February 2024

Background: Collagen represents a prominent constituent of the tumor’s extracellular matrix (ECM). Nonetheless, its correlation with the molecular subtype attributes of clear cell renal cell carcinoma (ccRCC) remains elusive. Our objective is to delineate collagen-associated molecular subtypes and further construct diagnostic model, offering insights conducive to the precise selection of ccRCC patients for immunotherapeutic interventions.Methods: We performed unsupervised non-negative matrix factorization (NMF) analysis on TCGA-KIRC samples, utilizing a set of 33 collagen-related differentially expressed genes (33CRDs) for clustering. Our analysis encompassed evaluations of subtype-associated differences in pathways, immune profiles, and somatic mutations. Through weighted gene co-expression network analysis (WGCNA) and four machine learning algorithms, two core genes were found and a diagnostic model was constructed. This was subsequently validated in a clinical immunotherapy cohort. Single cell sequencing analysis and experiments demonstrated the role of core genes in ccRCC. Finally, we also analyzed the roles of MMP9 and SCGN in pan-cancer.Results: We described two novel collagen related molecular subtypes in ccRCC, designated subtype 1 and subtype 2. Compared with subtype 1, subtype 2 showed more infiltration of immune components, but had a higher TIDE (tumor immunedysfunctionandexclusion) score and increased levels of immune checkpoint molecules. Furthermore, reduced prognosis for subtype 2 was a consistent finding in both high and low mutation load subgroups. MMP9 and SCGN were identified as key genes for distinguishing subtype 1 and subtype 2. The diagnostic model based on them could better distinguish the subtype of patients, and the differentiated patients had different progression free survival (PFS) in the clinical immunotherapy cohort. MMP9 was predominantly expressed in macrophages and has been extensively documented in the literature. Meanwhile, SCGN, which was overexpressed in tumor cells, underwent experimental validation, emphasizing its role in ccRCC. In various cancers, MMP9 and SCGN were associated with immune-related molecules and immune cells.Conclusion: Our study identifies two collagen-related molecular subtypes of ccRCC and constructs a diagnostic model to help select appropriate patients for immunotherapy.
Pest recognition in microstates state: an improvement of YOLOv7 based on Spatial and Channel Reconstruction Convolution for feature redundancy and vision transformer with Bi-Level Routing Attention
Authors: He Junjie , Zhang Shihao , Yang Chunhua , Wang Houqiao , Gao Jun , Huang Wei , Wang Qiaomei , Wang Xinghua , Yuan Wenxia , Wu Yamin , Li Lei , Xu Jiayi , Wang Zejun , Zhang Rukui , Wang Baijuan 
Published: February 2024

IntroductionIn order to solve the problem of precise identification and counting of tea pests, this study has proposed a novel tea pest identification method based on improved YOLOv7 network.MethodsThis method used MPDIoU to optimize the original loss function, which improved the convergence speed of the model and simplifies the calculation process. Replace part of the network structure of the original model using Spatial and Channel reconstruction Convolution to reduce redundant features, lower the complexity of the model, and reduce computational costs. The Vision Transformer with Bi-Level Routing Attention has been incorporated to enhance the flexibility of model calculation allocation and content perception.ResultsThe experimental results revealed that the enhanced YOLOv7 model significantly boosted Precision, Recall, F1, and mAP by 5.68%, 5.14%, 5.41%, and 2.58% respectively, compared to the original YOLOv7. Furthermore, when compared to deep learning networks such as SSD, Faster Region-based Convolutional Neural Network (RCNN), and the original YOLOv7, this method proves to be superior while being externally validated. It exhibited a noticeable improvement in the FPS rates, with increments of 5.75 HZ, 34.42 HZ, and 25.44 HZ respectively. Moreover, the mAP for actual detection experiences significant enhancements, with respective increases of 2.49%, 12.26%, and 7.26%. Additionally, the parameter size is reduced by 1.39 G relative to the original model.DiscussionThe improved model can not only identify and count tea pests efficiently and accurately, but also has the characteristics of high recognition rate, low parameters and high detection speed. It is of great significance to achieve realize the intelligent and precise prevention and control of tea pests.
A study on the applicability of the Strengths and Difficulties Questionnaire among low- and higher-educated adolescents
Authors: Theunissen Meinou H. C. , de Wolff Marianne S. , Eekhout Iris , van Vulpen Coryke , Reijneveld Sijmen A. 
Published: February 2024

AimThe Strengths and Difficulties Questionnaire self-report (SDQ-SR) is a valid instrument for detection of emotional and behavioral problems. The aim of this study was to compare the psychometric properties of the SDQ-SR for low and higher educated adolescents, and to explore its suitability.MethodsWe included 426 adolescents. We compared internal consistency for low-educated, i.e., at maximum pre-vocational secondary education, and higher educated adolescents and assessed whether the five-factor structure of the SDQ holds across educational levels. We also interviewed 24 low-educated adolescents, and 17 professionals.ResultsOn most SDQ subscales the low-educated adolescents had more problematic mean scores than the higher educated adolescents. Findings on the invariance factor analyses were inconsistent, with some measures showing a bad fit of the five factor model, and this occurring relatively more for the low-educated adolescents. Professionals and adolescents reported that the SDQ included difficult wordings.DiscussionOur findings imply that the scale structure of the SDQ-SR is slightly poorer for low educated adolescents. Given this caveat, psychometric properties of the SDQ-SR are generally sufficient for use, regardless of educational level.
Determinants of poor glycemic control among type 2 diabetes in Ethiopia: a systematic review and meta-analysis
Authors: Tegegne Kirubel Dagnaw , Gebeyehu Natnael Atnafu , Yirdaw Lehulu Tilahun , Yitayew Yibeltal Asmamaw , Kassaw Mesfin Wudu 
Published: February 2024

IntroductionPrior primary studies have examined the prevalence and factors associated with glycaemic control among patients with type 2 diabetes mellitus, but studies with evidence-based synthesis of the primary data remained unknown. Hence, we aimed to determine the prevalence of poor glycemic control and identify determinants of poor glycemic control in patients with type 2 diabetes in Ethiopia.MethodsWe performed searches in the online databases of PubMed, Google Scholar, Scopus, Science Direct, and the Cochrane Library. Microsoft Excel was used to extract data, and STATA statistical software (v. 16) was used for analysis. Publication bias was explored by forest plots, Begg’s rank test, and Egger’s regression test. To check for heterogeneity, I2 was computed. Subgroup analysis was conducted based on region and publication year. In addition, the pooled odds ratio for associated factors was calculated.ResultsOut of 1,045 studies assessed, 23 studies were included fulfilling our inclusion criteria. In all, 6,643 individuals were enrolled in the study. It was estimated that 61.11% of type 2 diabetes patients had poor glycemic control (95% CI, 57.14–65.19). The subgroup analysis by study region and publication year revealed that the highest prevalence was observed in the Addis Ababa region (68.57%) and studies published before 2019 (61.76%), respectively. Poor glycemic control was associated with older age &gt; 50 years (AOR = 2.12; 95% CI: 1.27–2.97), not attending formal education (AOR = 3.60; 95% CI: 2.75, 4.46), having diabetes for longer duration (10 years; AOR = 2.57; 95% CI: 1.65–3.49), having comorbidity (AOR = 2.43; 95% CI: 2.05–2.80), and low adherence to diabetes management (AOR = 3.67; 95% CI: 2.41–4.92).ConclusionOur findings indicate a high prevalence of poor glycemic control among people with type 2 diabetes in Ethiopia. Being older, not attending formal education, having a longer duration of diabetes, having comorbidity, and having low adherence to diabetes management were all associated. Therefore, we recommend health organizations implement measures to monitor and control patients’ blood glucose levels. Patient education and training of healthcare professionals could serve as a short-term strategy to achieve adequate glycemic control.Systematic review registrationPROSPERO, identifier CRD42022349792, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022349792.
Sigmoido-rectal intussusception anastomosis in the Altemeier procedure for complete rectal prolapse: preliminary results of a new technique
Authors: Wang Benjun , Han Weiwei , Zhai Yuze , Shi Renjie 
Published: February 2024

PurposeOur research introduces an innovative surgical approach, combining the Altemeier Procedure with Sigmoido-rectal Intussusception Anastomosis, effectively reducing recurrence, minimizing complications, and improving postoperative anal function in rectal prolapse patients.Materials and methodsThis retrospective study, conducted at tertiary referral hospitals including Shandong University of Traditional Chinese Medicine's Affiliated Hospital, Linyi People's Hospital, and Pingyi People's Hospital, examined data from patients undergoing conventional Altemeier surgery or Altemeier combined with Sigmoido-rectal Intussusception Anastomosis. Analyzing hospitalization and follow-up data from January 2009 to December 2022, the study focused on prolapse recurrence, complications, and anal function as primary outcome indicators across these three study centers.ResultsIn the study, both groups had an average follow-up of (12.5 ± 2.41) months, and only two traditional group patients experienced mortality. Recurrence rates significantly differed, with 26.47% in the traditional group and 1.54% in the modified group (P &lt; 0.001). The modified group showed no perioperative anastomotic dehiscence, contrasting with a 13.24% occurrence in the conventional group (P = 0.003). Primary complications in the modified group included anastomotic hemorrhage, with rates of 17.65% and 6.15% in the traditional and modified groups, respectively (P = 0.077). At 12 months postoperatively, both groups improved in anal manometry parameters and the Wexner anal incontinence score. Resting pressure was significantly lower in the traditional group (32.50 ± 1.76 mmHg) than the modified group (33.24 ± 2.06 mmHg) (P = 0.027), while the extrusion pressure was higher in the modified group (64.78 ± 1.55 mmHg) than the traditional group (62.85 ± 2.30 mmHg) (P &lt; 0.001). The Wexner anal incontinence score was significantly lower in the modified group (2.69 ± 1.65) than the traditional group (3.69 ± 1.58, P = 0.001).ConclusionThis retrospective study affirms that adding Sigmoido-rectal Intussusception Anastomosis to the Altemeier procedure reduces recurrence and complications. While both approaches enhance postoperative anal function in complete rectal prolapse patients, the combined method, particularly with Sigmoido-rectal Intussusception Anastomosis, proves more effective.
Gap-Free Tuning of Second and Third Harmonic Generation in Mechanochemically Synthesized Nanocrystalline LiNb1−xTaxO3 (0 ≤ x ≤ 1) Studied with Nonlinear Diffuse Femtosecond-Pulse Reflectometry
Authors: Klenen Jan , Sauerwein Felix , Vittadello Laura , Kömpe Karsten , Hreb Vasyl , Sydorchuk Volodymyr , Yakhnevych Uliana , Sugak Dmytro , Vasylechko Leonid , Imlau Mirco 
Published: February 2024

The tuning of second (SHG) and third (THG) harmonic emission is studied in the model system LiNb 1−xTa xO 3 (0≤x≤1, LNT) between the established edge compositions lithium niobate (LiNbO 3, x=0, LN) and lithium tantalate (LiTaO 3, x=1, LT). Thus, the existence of optical nonlinearities of the second and third order is demonstrated in the ferroelectric solid solution system, and the question about the suitability of LNT in the field of nonlinear and quantum optics, in particular as a promising nonlinear optical material for frequency conversion with tunable composition, is addressed. For this purpose, harmonic generation is studied in nanosized crystallites of mechanochemically synthesized LNT using nonlinear diffuse reflectometry with wavelength-tunable fundamental femtosecond laser pulses from 1200 nm to 2000 nm. As a result, a gap-free harmonic emission is validated that accords with the theoretically expected energy relations, dependencies on intensity and wavelength, as well as spectral bandwidths for harmonic generation. The SHG/THG harmonic ratio ≫1 is characteristic of the ferroelectric bulk nature of the LNT nanocrystallites. We can conclude that LNT is particularly attractive for applications in nonlinear optics that benefit from the possibility of the composition-dependent control of mechanical, electrical, and/or optical properties.
Digitalization of public administration and its pecularities and prospects in Ukraine
Authors: Yevtushenko Oleksandr 
Published: February 2024

The article analyzes the digitalization of public administration and its peculiarities as an instrument of socio-economic changes in Ukraine in the context of European integration, because digital technologies allow us to change the way territorial communities and regions function, increase the level of labor productivity and well-being of the population, and overcome challenges in the field of public administration.
It is discovered that digitalization creates a positive effect not only in public administration, but also in the field of economy, education, and culture, providing the saving in human, financial, and material resources, and promoting the solution of socially significant problems.
It is noted that digitalization, as a process of society's transition to digital technologies in all spheres of public life, forms a more inclusive society and better governance mechanisms and is a tool for achieving Ukraine's strategic goal of increasing GDP by 8 times, up to1 trillion USD in 2030.
It is determined that effective communication between society and public administration is possible only in the context of e-democracy, which involves the use of information technology by citizens, government, political parties at the local and regional levels, and improvement of procedures for providing and receiving public services. An example of e-democracy is the online platform «VzaiemoDiia»(Interaction), which expands the opportunities for citizens to participate in public administration processes, including vulnerable categories of the population, who currently have less opportunity to influence public decisions. Moreover, users will be able to receive high-quality feedback, since the Ministry of Digital Transformation not only collects all communication channels in a single «window» but also analyzes the imperfections to make each communication channel even more effective.
It is substantiated that the digitalization of public administration allows us to increase the amount of open data and strengthen the guarantees of access to publicly available information contained in state and municipal information systems. In fact it changes and transforms social relations, changes the process of performing functions by public authorities, expands their capabilities in making management decisions based on data obtained with the help of the information technology, and in particular in the processes of administration, provision of state and municipal services by citizens in electronic form, the establishment of digital communication channels, artificial intelligence, robotics, the Internet of things, big data analytics, and cloud technologies.
In further research, it is proposed to pay attention to the study of digitalization and digitalization processes in the executive and administrative activities of public administration entities.
The system of forming the protection of national values in the member states of the European Union
Authors: Larin Stanislav 
Published: February 2024

The relevance of the topic of the article is due to the fact that today in Ukraine the state mechanisms for the protection of national values, which are actively developing in the member states of the European Union, in particular in the field of international law, are not functioning effectively enough. Our European partners implement the protection of national values through their organizational and institutional state mechanisms, counting on the entire range of assistance within the EU.
The purpose of this article is to study the system of formation of the protection of national values in the member states of the European Union, which ensures the development of a democratic legal state and its public administration.
As a result, the dualism of the system of protection of national values in the member states of the European Union was investigated, which does not mean the mutual absorption of organizational or institutional state mechanisms or the primacy of one over the other. The system of protection of national values should be perceived as an expanded range of capabilities of the EU member states, which are united by a single civilizational dimension and have a completely material basis for building basic interaction among themselves. After all, the majority of EU member states are mononational, although in the context of the global migration trend, large ethnic groups from African and Asian countries are constantly entering the territory of the EU, which brings relevant features to the process of formation and implementation of internal state policy.
The utilitarian nature of the EU and the system of international legal norms that the Union implements through its organizational and institutional mechanisms is that member states can always count on the entire range of assistance, including in the context of ensuring sustainable development and protecting the system of national values. After all, for the EU and its members, the category of "national values" is taken absolutely literally, that is, in relation to each individual member state, such a system has its own expression and uniqueness.
Thus, it should be stated that the EU has its own system of basic values, which have been expressed both in separate legal acts and in the general idea of the European community. The latter is enshrined in the preamble of the Treaty on the European Union, where even the unity of the cultural, religious space and common historical past is reflected.
Factores de riesgo predominantes para el desarrollo de preeclampsia en embarazadas
Authors: Nuela-Masaquiza Catalina Fernanda , Romero-Fernández Ariel José , Gómez-Martínez Nairovys , Núñez-Zuñiga Ana Lorena 
Published: February 2024

Objetivo: identificar los factores de riesgo predominantes para el desarrollo de preeclampsia en embarazadas. Método: Descriptiva documental. Resultados y conclusión: Existen variedad de factores de riesgo predisponentes para la aparición de preeclampsia que no pueden ser unificados a pesar de ser un problema de salud mundial, dado a que varían de acuerdo condiciones demográficas, socioculturales y económicas de cada región por tanto es necesario que cada país establezca sus factores de riesgo enfocados a su grupo poblacional mediante el análisis de sus casos en particular para poder establecer criterios que permitan la identificación oportuna de factores de riesgo y una atención adecuada a la gestante a fin de minimizar las consecuencias a través de la aplicación de medidas actualizadas basadas en la evidencia.
موقف الحسن الثاني من عدم تنفيذ اتفاقية تسوية الحدود المغربية الجزائرية ( اتفاقية 9 شتنبر 1961)
Authors: التهامي فضيل 
Published: February 2024

منذ احتلال منطقة المغرب الكبير، عمدت الدول الاستعمارية إلى خلق مشاكل حدودية بين هذه الدول، ولم يسلم المغرب والجزائر من هذه المشاكل، بحيث أن فرنسا وبعد دخولها للمغرب والجزائر عمدت إلى تقسيم أراضي التابعة للتراب المغربي وإلحاقها بالجزائر. وفي هذا السياق قامت الحكومة المغربية (الحسن II) والحكومة الجزائرية المؤقتة (فرحات عباس) إلى عقد اتفاقية لتسوية الحدود المغربية الجزائرية (9 شتنبر 1961). فقد نصت هذه الاتفاقية على أن المغرب سيساند الشعب الجزائري في معركته ضد الاستعمار، والدفاع على وحدته الوطنية، وسيعارض أي تقسيم للتراب الجزائري، وبالمقابل تعترف الحكومة الجزائرية بأن مشكلة الأراضي التي أقرت فرنسا حدودها بصفة جائرة سيوجد لها حلا بواسطة المفاوضات بين الطرفين لكن بعد استقلال الجزائر ظهرت مجموعة من التطورات على أرض الواقع، بحيث قامت الحكومة المغربية بمطالبتها بتنفيذ الاتفاقية المبرمة بين الجانبين، لكن تعذر عليها ذلك، بسبب تغير المواقف الجزائرية التي أصبحت ترى أن الاتفاقية المبرمة لم تعد صالحة، وبالتالي أقرت الجزائر بأن المغرب تجاهل مجموعة من الحقائق باعتبار أن الحقوق التاريخية لمغربية الأراضي قد تجاوزها الزمن، إضافة إلى أن منظمة الوحدة الإفريقية اعتمدت مبدأ احترام الحدود الموروثة عن الاستعمار.
الكلمات المفتاحية:المغرب،حدود،الجزائر،إتفاقية،حقوق تاريخية.
NURTURING INTER-ORGANIZATIONAL RELATIONSHIPS TO INCREASE ECONOMIC AND SOCIAL PERFORMANCE
Authors: Bernardino Susana , Freitas Santos J. , Mendonça da Silva Pedro 
Published: February 2024

The study adopts a network perspective to develop a conceptual model that proposes several hypotheses to examine the role of inter-organizational relationships with different stakeholders (funders/donors, other social organizations, government institutions) in the process of resources’ mobilization for social organizations and the impacts on the social and economic performance.
The research uses primary data collected from the managers of social organisations and applies structural equation modelling, to test the hypotheses of the base model. The results indicate that the governance of inter-organizational relationships determines the process of resources’ mobilization and, consequently, enhances the social and economic performance of the social organizations.
The findings suggest that our understanding of the process of resources acquisition by social organizations could be enriched by integrating the network perspective into the specific context of social management.
Efektivitas Penerapan Pengendalian Intern Dalam Menurunkan Kredit Usaha Rakyat (Kur) Macet Bagi Nasabah Bank Rakyat Indonesia (Bri) Unit Aloei Saboe Kota
Authors: Daipaha Risnawati , Mattoasi Mattoasi , Usman Usman 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui efektivitas penerapan sistem pengendalian intern Bank Rakyat Indonesia (BRI) Unit Aoei Saboe Kota Gorontalo dalam menurunkan KUR macet. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif dengan menggunakan sumber data primer yang diperoleh secara langsung dari observasi dan wawancara serta data hasil dokumentasi. Hasil penelitian yang menunjukkan bahwa penerapan pengendalian intern Bank Rakyat Indonesia (BRI) Unit Aloei Saboe Kota Gorontalo sudah cukup efektif dalam menurunkan nilai kredit macet. Bentuk upaya pengendalian yang dilakukan oleh bank BRI cabang Gorontalo unit Aloei Saboe jika terjadi kredit macet dilakukasn restrukturisasi, perpanjangan waktu dan perubahan tingkat suku bunga, namun terjadinya kredit macet karena nasabah tidak memiliki itikad baik sehingga gagal bayar.