bluuebunny/crossref_metadata_2025_split huggingface dataset:
A robust multinutrient kinetic model for enhanced lutein and biomass yields in mixotrophic microalgae cultivation: A step towards successful large‐scale productions
Authors: Bentahar Jihed , Deschênes Jean‐Sébastien 
Published: February 2024

AbstractMixotrophic cultivation holds great promise to significantly enhance the productivities of biomass and valuable metabolites from microalgae. In this study, a new kinetic model is developed, explicitly describing the effect of the most influential environmental factors on both biomass growth and the production of the high‐value product lutein. This extensive study of multinutrient kinetics for Tetradesmus obliquus in a mixotrophic regime covers various nutritional conditions. Crucial nutrients governing the model include nitrate, phosphate, and glucose. Using seven state variables and 13 unknown parameters, the model's accuracy was ensured through a well‐designed two‐factor, four‐level experimental setup, providing ample data for reliable calibration and validation. Results accurately predict dynamic concentration profiles for all validation experiments, revealing broad applicability. Optimizing nitrogen availability led to significant increases in biomass (up to fourfold) and lutein production (up to 12‐fold), with observed maximum biomass concentration of 6.80 g L−1 and lutein reaching 25.58 mg L−1. Noticeably, the model exhibits a maximum specific growth rate of 4.03 day−1, surpassing reported values for photoautotrophic and heterotrophic conditions, suggesting synergistic effects. Valuable guidance is provided for applying the method to various microalgal species and results are large‐scale production‐ready. Future work will exploit these results to develop real‐time photobioreactor operation strategies.
Structurally Diverse Coumarins from Peucedanum praeruptorum and their Anti‐Inflammatory Activities via NF‐κB Signaling Pathway
Authors: Lin Kai‐Qin , Liu Han‐Fei , Chen Chao , Li Jin‐Yu , Pan Wei‐Dong , Sun Chao , Lou Hua‐Yong 
Published: February 2024

AbstractThe phytochemical study of Peucedanum praeruptorum led to the isolation of twenty‐five coumarins (1‐25). Of which, (±) praeruptol A (±1), one pair of previous undescribed seco‐coumarin enantiomers were obtained. Their structures were established according to HR‐ESI‐MS, NMR, X‐ray single crystal diffraction analysis, as well as ECD calculation. All compounds were tested for anti‐inflammatory activity in the RAW264.7 macrophage model, and eight compounds (7–10, and 13–16) exhibited significant inhibitory effects with IC50 values ranging from 9.48 to 34.66 μM. Among them, compound 7 showed the strongest inhibitory effect, which significantly suppressed the production of IL‐6, IL‐1β, and TNF‐α, as well as iNOS and COX‐2 in a concentration‐dependent manner. Further investigated results showed that compound 7 exerted an anti‐inflammatory effect via the NF‐κB signaling pathway.
Atraumatic intra‐articular, extra‐synovial ganglion cyst of the lateral knee deep to the iliotibial band: A case report and review of the literature
Authors: Guzman Alvarho , Williams Nicholas , Dela Rueda Therese , Xiao Edward , Caliman Arina , Chen James L. , McGahan Patrick J. 
Published: February 2024

Key Clinical MessageWe highlight the rare case of an atraumatic, intra‐articular ganglion cyst of the lateral knee deep to the iliotibial band that was successfully treated nonoperatively, a pathology yet to be reported in orthopedic literature.AbstractGanglion cysts are mucin‐filled synovial cysts commonly found on the dorsal surface of the hands and feet. Intra‐articular ganglion cysts of the knee are rare, and when they present clinically, are typically treated operatively through arthroscopic surgery. We present the first reported case of an atraumatic intraarticular, extra‐synovial ganglion cyst of the lateral knee located deep to the iliotibial band that was successfully treated without operative intervention through repeated intra‐articular aspirations of the knee.
A rare case of giant mediastinal thymolipoma in an 18‐year man
Authors: Soleimani Hourieh , Aminzadeh Behzad , Hassannejad Ehsan , Payandeh Asma , Oudi Batul , Karimabadi Neda 
Published: February 2024

Key Clinical MessageThymolipoma is a rare benign thymic lesion that can manifest as a sizable anterior mediastinal mass. Considering their rarity and challenging preoperative diagnosis, it is crucial to consider these tumors when dealing with anterior mediastinal masses.
Carbon Covering Method to Enhance the Storage Capacity of Materials Belonging to the Conversion and Alloy Storage Types
Authors: Mu Yuan , Li Jianke , Wang Kun , Xu Guiying , An Baigang , Zhou Weimin 
Published: February 2024

AbstractDriven by the development of energy storage systems (EESs), finding alternative anode materials forlithium‐ion batteries to replace the general carbon materials is becoming a hot research topic in the world. Using the metal oxides, metal sulfides, metal phosphides, metal selenides belonging to the conversion type and Sn, Sb, Bi, Ge, P and Si belonging to the alloy storage type seems to be a preferred option. Nevertheless, the demerits such as volume expansion and bad conductivity of alternative materials restrict their practical application. Carbon covering is an efficacious strategy to deal with the aforementioned issues because it can restrict the volume expansion and improve the conductivity of the composite materials effectively. This present review paper comprehensively describes the suitable carbon resources and preparation methods for expanding the practical applications of materials belonging to the conversion type and ally type in fabrications of negative electrodes.
Enhanced Photoelectrochemical Activity Realized from WS2 Thin Films Prepared by RF‐Magnetron Sputtering for Water Splitting
Authors: Ladhane Somnath , Shah Shruti , Shinde Pratibha , Punde Ashvini , Waghmare Ashish , Hase Yogesh , Bade Bharat R. , Doiphode Vidya , Rahane Swati N. , Kale Dhanashri , Rondiya Sachin R. , Prasad Mohit , Patole Shashikant P. , Jadkar Sandesh R. 
Published: February 2024

AbstractWe report the synthesis of tungsten sulfide (WS2) films using RF‐magnetron sputtering at different RF powers. X‐ray diffraction (XRD) data confirm the hexagonal crystal structure of WS2 with an average crystallite size of ∼44.54 Å. With increased RF power, the preferred orientation of WS2 crystallites shifts from (002) to (100). Linear sweep voltammetry (LSV) was used to assess the Photoelectrochemical (PEC) activity of WS2 films. The film deposited at 150 W demonstrated the highest photocurrent density of 5.44 mA/cm2. The 150 W film also showed a lower Tafel slope of ∼0.374 V/decade, indicating superior PEC activity. Mott Schottky's (MS) analysis revealed a notable shift in the flat band potential towards the negative side, suggesting a shifting of the Fermi level towards the conduction band. WS2 film grown at 150 W demonstrated a majority charge carrier density of 6.2×1021 cm−3 and a depletion layer width of 1.54 nm. The observed low charge transfer resistance of 155 Ω contributed to the enhanced PEC activity with a relaxation time constant of 37 ms. These properties suggest that WS2 can be suitable for PEC water splitting.
Regulation of Electronic Structures of the Urchin‐Like NiCoP/CoP Nanocatalysts for Fast Hydrogen Evolution
Authors: Chen Xiaodong , Luo Xiaoling , Zhang Xuefeng , Wang Huize , Li Yongcheng , Ye Lifang , Zheng Jiahua , Li Hao 
Published: February 2024

AbstractThe exploration of stable, efficient, and low‐cost catalysts toward ammonia borane hydrolysis is of vital significance for the practical implementation of this hydrogen production technology. Integrating interface engineering and nano‐architecture engineering is a favorable strategy to elevate catalytic performance, as it can modify the electronic structure and provide sufficient active sites simultaneously. In this work, urchin‐like NiCoP/CoP heterostructures are prepared via a three‐step hydrothermal‐oxidation‐phosphorization synthesis route. It is demonstrated that the original Ni/Co molar ratio and the amount of phosphorus are crucial for adjusting the morphology, enhancing the exposed surface area, facilitating charge transfer, and modulating the adsorption and activation of H2O molecules. Consequently, the optimal Ni1Co2P heterostructure displays remarkable catalytic properties in the hydrolysis of ammonia borane with a turnover frequency (TOF) value of 30.3 molH2 ⋅ min−1 ⋅ molmetal−1, a low apparent activation energy of 25.89 kJ ⋅ mol−1, and good stability. Furthermore, by combining infrared spectroscopy and isotope kinetics experiments, a possible mechanism for the hydrolysis of ammonia borane was proposed.
Fenton‐Like Reaction: Recent Advances and New Trends
Authors: Xiao Jiaying , Guo Sufang , Wang Dong , An Qi 
Published: February 2024

AbstractThe Fenton reaction refers to the reaction in which ferrous ions (Fe2+) produce hydroxyl radicals and other reactive oxidizing substances by decomposing hydrogen peroxide (H2O2). This paper reviews the mechanism, application system, and materials employed in the Fenton reaction including conventional homogeneous and non‐homogeneous Fenton reactions as well as photo‐, electrically‐, ultrasonically‐, and piezoelectrically‐triggered Fenton reactions, and summarizes the applications in the degradation of soil oil pollutions, landfill leachate, textile wastewater, and antibiotics from a practical point of view. The mineralization paths of typical pollutant are elucidated with relevant case studies. The paper concludes with a summary and outlook of the further development of Fenton‐like reactions.
Carboranylphosphines: B9‐Substituted Derivatives with Enhanced Reactivity for Anchoring to Dendrimers
Authors: Milewski Max , Caminade Anne‐Marie , Mallet‐Ladeira Sonia , Lledós Agustí , Lönnecke Peter , Hey‐Hawkins Evamarie 
Published: February 2024

AbstractInvited for the cover of this issue are the groups and colleagues of Anne‐Marie Caminade at the CNRS and University of Toulouse, Evamarie Hey‐Hawkins at Leipzig University, and Agustí Lledós from the Autonomous University of Barcelona. The image depicts birds crowned by a carborane competing for access to food, to illustrate the steric hindrance encountered when grafting carboranes to dendrimers (artwork by Dr. Christoph Selg). Read the full text of the article at 10.1002/chem.202303867.
Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS)
Authors: Pal Sandeep , Nare Zandile , Rao Vincenzo A. , Smith Brian O. , Morrison Ian , Fitzgerald Edward A. , Scott Andrew , Bingham Matilda J. , Pesnot Thomas 
Published: February 2024

AbstractWe report the development of BioPhysical and Active Learning Screening (BioPALS); a rapid and versatile hit identification protocol combining AI‐powered virtual screening with a GCI‐driven biophysical confirmation workflow. Its application to the BRPF1b bromodomain afforded a range of novel micromolar binders with favorable ADMET properties. In addition to the excellent in silico/in vitro confirmation rate demonstrated with BRPF1b, binding kinetics were determined, and binding topologies predicted for all hits. BioPALS is a lean, data‐rich, and standardized approach to hit identification applicable to a wide range of biological targets.
Investigating the Combined Toxicity of Cu(II) and Carbon Monoxide (CO); Cellular CO Delivery Using a Cu(II) Flavonolato Complex
Authors: Anderson Stephen N. , Dederich C. Taylor , Elsberg Josiah G. D. , Benninghoff Abby D. , Berreau Lisa M. 
Published: February 2024

AbstractCarbon monoxide (CO) delivery molecules are of significant current interest as potential therapeutics, including for anticancer applications. A recent approach toward generating new types of materials‐based anticancer agents involves combining the Fenton reactivity of a redox active metal ion with CO delivery. However, small molecule examples of these types of entities have not been systematically studied to evaluate the combined effect on cellular toxicity. Herein we describe a Cu(II) flavonolato complex which produces anticancer effects through a combination of copper‐mediated reactive oxygen species (ROS) generation and light‐induced flavonol CO release. Confocal microscopy studies provide evidence of enhanced flavonol uptake in the copper flavonolato system relative to the free flavonol, which leads to an increased amount of CO delivery within cells. Importantly, this work demonstrates that a metal flavonolato species can be used to produce enhanced toxicity effects resulting from both metal ion‐induced Fenton reactivity and increased cellular uptake of a flavonol CO donor.
Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study
Authors: van der Plas Ellen , Darji Himani , Srivastava Deo K. , Schapiro Melissa , Jeffe Donna , Perkins Stephanie , Howell Rebecca , Leisenring Wendy , Armstrong Gregory T. , Oeffinger Kevin , Krull Kevin , Edelstein Kim , Hayashi Robert J. 
Published: February 2024

AbstractBackgroundPrevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well‐established.MethodsParticipants in this cross‐sectional, case‐control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.5 [6.6] years; n = 706 siblings, 57.2% female; mean age, 32.8,[7.9] years) completed measures of neurocognition, emotional distress, and health‐related quality of life (HRQOL). Multivariable logistic regression models identified treatments, health behaviors, and chronic conditions associated with impairment.ResultsRelative to siblings, more survivors reported neurocognitive impairment (task efficiency: 21.1% vs. 13.7%, emotional regulation: 16.7% vs. 11.0%, memory: 19.3% vs. 15.1%), elevated emotional distress (somatic distress: 12.9% vs. 4.7%, anxiety: 11.7% vs. 5.9%, depression: 22.8% vs. 16.9%) and poorer HRQOL (physical functioning: 11.1% vs. 2.8%, role functioning due to physical problems: 16.8% vs. 8.2%, pain: 17.5% vs. 10.0%, vitality: 22.3% vs. 13.8%, social functioning: 14.4% vs. 6.8%, emotional functioning: 17.1% vs. 10.6%). Cranial radiation increased risk for impaired task efficiency (odds ratio [OR], 2.30; 95% confidence interval [CI], 1.14–4.63), whereas chest and pelvic radiation predicted increased risk of physical functioning (OR, 2.68; 95% CI, 1.16–6.21 and OR, 3.44; 95% CI, 1.70–6.95, respectively). Smoking was associated with impaired task efficiency (OR, 2.06; 95% CI, 1.14–3.70), memory (OR, 2.23; 95% CI, 1.26–3.95), anxiety (OR, 2.71; 95% CI, 1.36–5.41) and depression (OR, 1.77; 95% CI, 1.01–3.11). Neurologic conditions increased risk of anxiety (OR, 2.30; 95% CI, 1.04–5.10), and hearing conditions increased risk of depression (OR, 1.79; 95% CI, 1.05–3.03). Neurologic and hearing conditions, respectively, were associated with impaired memory (OR, 2.44; 95% CI, 1.20–4.95 and OR, 1.87; 95% CI, 1.05–3.35) and poor health perception (OR, 2.62; 95% CI, 1.62–1.28 and OR, 2.33; 95% CI, 1.34–4.06).ConclusionsRMS survivors are at significant risk for poor psychological outcomes. Advancing therapies for local control, smoking cessation, and managing chronic medical conditions may mitigate poor outcomes following RMS.
Myelofibrosis: Current unmet needs, emerging treatments, and future perspectives
Authors: Harrison Claire N. , Kiladjian Jean‐Jacques , Koschmieder Steffen , Passamonti Francesco 
Published: February 2024

AbstractThe current standard‐of‐care for treatment of myelofibrosis (MF) comprises inhibitors of the Janus kinase (JAK)/signal transducers and activators (STAT) pathway; however, despite their ability to alleviate symptoms, they do not appear to modify underlying disease and have not demonstrated substantial survival benefit. Allogeneic‐hematopoietic stem cell transplantation remains the only curative option for patients with MF but is limited to a subset of high‐risk and fit patients. Early disease modification could positively affect disease trajectory for lower risk patients with MF as well as those with conditions that can precede MF, such as polycythemia vera and essential thrombocythemia. Here, the authors discuss critical unmet needs in the MF treatment paradigm, including: the need for safe, impactful therapies for lower risk patients, thus allowing intervention when success is most likely; better development of first‐line therapies (likely highly novel or combination strategies) for intermediate‐risk/higher risk patients; and approved drugs to manage cytopenia. Finally, a consensus definition of disease modification is needed that informs trial design, allowing the development of clinical end points that enable understanding of therapies and responses and that facilitate the development of therapies that work according to this definition. Through close collaboration between clinicians, patients, and the pharmaceutical industry, better efforts to define benefit and identify patients most likely to benefit from a particular combination or treatment strategy should enable the development of more effective and safe treatments to extend and improve quality of life for patients with MF.
Marigold Like Structure from Methionine Mediated Growth of Positively Charged Gold Nanorod
Authors: Sahu Jitendra K. , Sadhu Kalyan K. 
Published: February 2024

AbstractDuring morphological evolution of gold nanoparticles, amino acids play a vital role in tuning shape, introducing chirality and inducing facet selective reactivity. Herein, we report the synthesis of unique marigold like structure (MGS) via growth reaction of methionine (Met) incubated positively charged anisotropic gold nanorod (GNR). Varying three important parameters such as growth time, concentration of Met and Au3+ reveals the combination of freshly generated small nucleated particles (fNPs) and GNR towards fabricating the unique MGS containing disk and ray floret parts. Strong interaction between Met and (111) plane of Au0 controls the orientation of (111) plane parallel to the direction of growth. This preferential interaction directs the assembly of gold nanostructures through Au (200) plane and results in merging of fNPs with concave GNR (cGNR) to fabricate the external arrangement of ray floret structure. The structural selectivity is attributed to the electron donating capacity of thioether functional group of Met(S) to Au+, generated prior to secondary nucleation. As confirmed by XPS and ζ‐potential analysis, the above interaction controls the Met concentration dependent inhibition of further Au+→Au0 reduction. The growth strategy of GNR has been further validated with a Met enriched peptide to produce disk and ray florets.
Hexagonal Boron Nitride Spacers for Fluorescence Imaging of Biomolecules
Authors: Yang Xiliang , Shin Dong Hoon , Yu Ze , Watanabe Kenji , Taniguchi Takashi , Babenko Vitaliy , Hofmann Stephan , Caneva Sabina 
Published: February 2024

AbstractFluorescence imaging is an invaluable tool to investigate biomolecular dynamics, mechanics, and interactions in aqueous environments. Two‐dimensional materials offer large‐area, atomically smooth surfaces for wide‐field biomolecule imaging. Despite the success of graphene for on‐chip biosensing and biomolecule manipulation, its strong fluorescence‐quenching properties pose a challenge for biomolecular investigations that are based on direct optical readouts. Here, we employ few‐layer hexagonal boron nitride (hBN) as a precisely tailorable fluorescence spacer between labelled lipid membranes and graphene substrates. By stacking high‐quality hBN crystals in the 10–20 nm thickness range on monolayer graphene, we observe distance‐dependent fluorescence intensity variations. Remarkably, with hBN spacers as thin as 20 nm, the fluorescence intensity is comparable to bare SiO2/Si substrates, while the intensity was reduced to 60 % and 80 % with ~10 nm and ~16 nm hBN thicknesses respectively. We confirm that pre‐determined hBN thicknesses can be employed to control the non‐radiative energy transfer properties of graphene, with fluorescence quenching following a d−4 distance‐dependent behaviour. This seamless integration of electronically active and dielectric van der Waals materials into vertical heterostructures enables multifunctional platforms addressing the manipulation, localization, and visualization of biomolecules for fundamental biophysics and biosensing applications.
Cyanide Bridged Framework Nanoplates Catalytic Interlayer for High Performance Zinc‐Iodine Battery
Authors: Zhao Hongyang , Yin Dandan , Zhao Lanya , Ding Shujiang 
Published: February 2024

AbstractIodine is a promising candidate among the cathode materials in zinc‐ion battery. However, iodine cathode suffers from serious shuttle effect by spontaneous generated polyiodide species. In this work, we developed a CoNi(CN)4/CNT interlayer to prevent shuttle effect by adsorption‐catalysis process. The adsorption of the iodine species on CoNi(CN)4/CNT interlayer is justified by UV‐vis spectroscopy and X‐ray photoelectron spectroscopy, where the concentration of polyiodides is significantly reduced, and the binding energy of cobalt, nickel, and nitrogen is remarkably reduced by binding with polyiodides. The zinc‐iodine dual‐plating battery shows significantly higher areal capacity and cycle stability with CoNi(CN)4/CNT. Moreover, battery with impressive areal capacity of 3.6 mAh cm−2 and negligible fading over 100 cycles is also achieved, which outperforms state‐of the art literatures on zinc‐iodine batteries.
Control of Liquid–Liquid Phase Separation, Nucleation, and Growth of L‐Menthol Single Crystals from Water–Ethanol Solvent Mixtures
Authors: Murugan Kowsalya , Karuppannan Srinivasan 
Published: February 2024

AbstractL‐Menthol is a commonly used material in food production for flavor enhancement and fragrances, as well as in pharmaceuticals. However, during the solution crystallization process of L‐menthol, there is a major issue of oiling out or liquid–liquid phase separation (LLPS) in most organic solvents and their mixtures. The objective of the current work is to prevent the LLPS phenomenon and grow high‐quality single crystals of L‐menthol. A water–ethanol mixed solvent with nine different mixing ratios is used, ranging from 0.99W:0.01E to 0.91W:0.09E, through the conventional slow evaporation process. The findings indicate that the mixing composition of the solvent plays a significant role in the variation of solubility, refractive index, LLPS, nucleation, and crystallization. This is clearly demonstrated in the phase diagram. The occurrence of LLPS phenomenon, nucleation, growth behavior, and morphology of L‐menthol single crystals through optical microscopy is identified. Additionally, the internal structure and thermal stability of the grown polymorphs using PXRD, SCXRD, and DSC analyses are confirmed.
Development of a Thermodynamically Favorable Multi‐enzyme Cascade Reaction for Efficient Sustainable Production of ω‐Amino Fatty Acids and α,ω‐Diamines
Authors: Li Ju‐Mou , Shi Kun , Li Ai‐Tao , Zhang Zhi‐Jun , Yu Hui‐Lei , Xu Jian‐He 
Published: February 2024

AbstractInvited for this issue's cover is the group of Huilei Yu at the East China University of Science and Technology. The image shows a sustainable biosynthesis route to nylon monomers from bio‐based substrate α, ω‐dicarboxylic acids. The Research Article itself is available at 10.1002/cssc.202301477.