bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Hydrocolloid Dressing untuk Mengatasi Maserasi Luka
Authors: Hidayat Rizki , Naziyah Naziyah , Mufidah Zahrah 
Published: October 2023

ABSTRACT Any wound will have risks and side effects leading to maceration. Maceration is a break in the skin due to damage to the skin's protective function (acute wound). If maceration occurs, the surrounding wound will feel painful and uncomfortable. Indications for maceration in wounds that have minimal exudate, then using hydrocolloid dressing. This study aims to determine the effect of hydrocolloid dressing to treat wound maceration. The research design is quasi-experimental with a pretest - posttest design approach, namely this design is carried out initial measurement through pretest, then given action or intervention, after which it is continued by giving a posttest. The sample technique used was total sampling with a sample size of 20 respondents. The research instrument used was the BWAT sheet. The statistical test used was the paired sample t-test. The results of the study found an average BWAT score with a pretest of 33.15 ± 9.697 and a posttest of 21.85 ± 7.242. The results showed a difference between BWAT measurement scores before and after being given hydrocolloid dressing with a p-value of 0.000 (p <0.05). After being given hydrocolloid dressing for wound maceration, the p-value is 0.000 (p<0.05) so that hydrocolloid dressing has an influence in overcoming wound maceration. Keywords: BWAT, Hydrocolloid Dressing, Maceration, Wound ABSTRAK Setiap luka akan memungkinkan berdampak pada resiko dan efek samping yang menyebabkan maserasi (luka akut). Maserasi merupakan kerusakan pada fungsi perlindungan kulit pada sekitar luka akibat retensi cairan. Jika terjadi maserasi, maka sekitar luka akan terasa sakit dan tidak nyaman. Indikasi maserasi pada luka yang memiliki minim eksudat, maka dengan menggunakan hydrocolloid dressing. Penelitian ini bertujuan untuk mengetahui pengaruh hydrocolloid dressing untuk mengatasi maserasi luka. Desain penelitian berbentuk quasy eksperiment dengan pendekatan pretest – posttest design yaitu desain ini dilakukan pengukuran awal melalui pretest, kemudian diberikan tindakan atau intervensi, setelah itu dilanjutkan dengan memberikan posttest. Teknik sampel yang digunakan adalah total sampling dengan jumlah sampel 20 responden. Instrument penelitian yang digunakan yaitu lembar BWAT. Uji statistik yang digunakan yaitu uji paired sample t-test. Hasil penelitian didapatkan rata-rata skor BWAT dengan pretest sebesar 33,15 ± 9,69 dan posttest sebesar 21,85 ± 7,24. Hasil penelitian menunjukkan adanya perbedaan antara skor pengukuran BWAT sebelum dan sesudah diberikan hydrocolloid dressing dengan nilai p-value sebesar 0,000 (p<0,05). Setelah diberikan hydrocolloid dressing untuk maserasi luka, maka didapatkan nilai p-value sebesar 0,000 (p<0,05) sehingga hydrocolloid dressing memiliki pengaruh dalam mengatasi maserasi luka. Kata Kunci: BWAT, Hydrocolloid Dressing, Luka, Maserasi
Pelatihan Pembuatan Pupuk Kompos Dari Daun Kering
Authors: Argarini Dian Fitri , Rochsun Rochsun , Sunuyeko Nurcholis , Litik Bernadeti Sartika Yasni 
Published: October 2023

The Potential Based Community Service (PMBP) activity aims to provide education to the community in Ciwulan RW 12, Purwantoro Village, Kec. Blimbing Malang City regarding how to make compost from dry leaf waste. The benefit of making compost from dry leaves is to help local residents in making organic fertilizer from nature and optimizing the use of dry leaf waste so that the dry leaves can have high use value and are useful as compost. Processing dry leaf waste into organic fertilizer can increase public knowledge and insight about making compost and can reduce dependence on the use of inorganic fertilizers that contain many compounds that are less environmentally friendly. This training was attended by the Ciwulan 12 community. The method used is in the form of hands-on practice and simulation. The result of this training is that the people of Purwantoro Village can make compost using natural ingredients and increase the knowledge and insight of the community in Ciwulan RW 12 Kel. Purwantoro Kec. Blimbing City of Malang
Evaluation of biomechanical properties and biocompatibility: are partially absorbable cords eligible for anterior cruciate ligament reconstruction?
Authors: Xu Fei , Li Yanlin , Yu Yang , Wang Guoliang , Cai Guofeng 
Published: October 2023

Introduction: Independent augmentation technology based on reinforcing devices has been reported to signifi-cantly reduce the elongation behavior of graft and improve knee stability after anterior cruciate ligament reconstruction (ACLR). Using biodegradable devices could reduce the risk of severe inflammatory reactions due to particle accumulation from foreign bodies. Given the limitations of the mechanical properties of biodegradable materials, partially biodegradable composite devices may offer a compromise strategy.Methods: Three types of partially absorbable core-sheath sutures, including low-absorbable cord (LA-C), medium-absorbable cord (MA-C) and high-absorbable cord (HA-C), were braided using unabsorbable ultra-high molecular weight polyethylene (UHMWPE) yarn and absorbable polydioxanone (PDO) monofil-ament bundle based on the desired configuration. The feasibility of these partially absorbable cords were verified by biomechanical testing, material degradation testing, and cell experiments, all performed in vitro.Results: Reinforcement of an 8 mm graft with the cords decreased dynamic elongation by 24%–76%, was positively related to dynamic stiffness, and increased the failure load by 44%–105%, during which LA-C showed maximum enhancement. Human ligament-derived fibroblasts showed good proliferation and vitality on each cord over 2 weeks and aligned themselves in the direction of the fibers, especially the UHMWPE portion.Discussion: This study supports the potential of partially degradable UHMWPE/PDO cords, particularly LA-C, for graft protection. Nervertheless, a higher proportion of biodegradable material results in lower stiffness, which may impair the protective and lead to mechanical instability during degradation.
Can the development of digital construction reduce enterprise carbon emission intensity? New evidence from Chinese construction enterprises
Authors: Yang Xiaozhuang , Lei Gaowei , Wang Xiaoyu 
Published: October 2023

IntroductionWith the rapid development of digital technology and its deep integration with the engineering and construction field, digital construction has become an effective way for low-carbon transformation in the construction industry. However, there is a gap of empirical research between digital construction and carbon emissions. MethodsThis paper empirically investigates the impact of digital construction level on carbon emission intensity and the mechanism of action by using the two-way fixed effects model and mechanism testing based on the panel data of 52 Shanghai and Shenzhen A-share listed companies in China’s construction industry from 2015 to 2021. ResultsThe findings indicate that the improvement of digital construction level can significantly decrease the carbon emission intensity of construction enterprises, and the conclusions still hold after robustness tests and discussions on endogeneity issues such as replacing core explanatory variables, replacing models, using instrumental variables method, system GMM model and difference in differences model. According to a mechanism analysis, digital construction can curb carbon emission intensity by enhancing the R&amp;D innovation capacity and total factor productivity of enterprises. Furthermore, the heterogeneity analysis shows that the improvement of digital construction level in state-owned enterprises as well as civil engineering construction enterprises can better contribute to reducing carbon emission intensity. DiscussionThis paper will provide a reference for the synergistic optimization of digital construction development and carbon emissions reduction in construction enterprises. The research conclusions are going to promote the digital transformation of the construction industry to accelerate the achievement of the carbon peaking and carbon neutrality goals.
Immune-related signature of periodontitis and Alzheimer’s disease linkage
Authors: Jin Jieqi , Guang Mengkai , Li Simin , Liu Yong , Zhang Liwei , Zhang Bo , Cheng Menglin , Schmalz Gerhard , Huang Xiaofeng 
Published: October 2023

Background: Periodontits (PD) and Alzheimer’s disease (AD) are both associated with ageing and clinical studies increasingly evidence their association. However, specific mechanisms underlying this association remain undeciphered, and immune-related processes are purported to play a signifcant role. The accrual of publicly available transcriptomic datasets permits secondary analysis and the application of data-mining and bioinformatic tools for biological discovery.Aim: The present study aimed to leverage publicly available transcriptomic datasets and databases, and apply a series of bioinformatic analysis to identify a robust signature of immune-related signature of PD and AD linkage.Methods: We downloaded gene-expresssion data pertaining PD and AD and identified crosstalk genes. We constructed a protein-protein network analysis, applied immune cell enrichment analysis, and predicted crosstalk immune-related genes and infiltrating immune cells. Next, we applied consisent cluster analysis and performed immune cell bias analysis, followed by LASSO regression to select biomarker immune-related genes.Results: The results showed a 3 gene set comprising of DUSP14, F13A1 and SELE as a robust immune-related signature. Macrophages M2 and NKT, B-cells, CD4+ memory T-cells and CD8+ naive T-cells emerged as key immune cells linking PD with AD.Conclusion: Candidate immune-related biomarker genes and immune cells central to the assocation of PD with AD were identified, and merit investigation in experimental and clinical research.
Characteristics and factors influencing the volume of breastmilk donated by women to the first human milk bank in Vietnam
Authors: Tran Hoang Thi , Nguyen Tuan Thanh , Nguyen Oanh Thi Xuan , Barnett Debbie , Weaver Gillian , Mathisen Roger 
Published: October 2023

BackgroundDonor human milk (DHM) is essential to the operation of human milk banks (HMB). This study examined characteristics and factors associated with higher volumes of DHM donation at the first HMB in Vietnam.MethodData from an online HMB monitoring system collected between February 2017 and July 2022 included demographic characteristics, child information, the timing of donation, and the volume of DHM. Higher volume is defined as equal to or greater than the median DHM volume per donor of 14.4 liters (L). Potential contributors to higher DHM volume were examined using the chi-square test in univariate and multivariable logistic regression analysis.ResultsDuring the 5.5-year operation, this HMB recruited 517 donors with an average age of 28.6 years. Approximately 60.9% of donors had a college or higher degree and 97.3% gave birth in Da Nang city. Of these donors, the prevalence of cesarean birth was 48.2%, preterm births was 40.2%, and 27.9% had babies with a birth weight of less than 1,500 g. There was a similar proportion of donors between the hospital (48.2%) and community (51.8%). On average, hospital donors started their donations 15 days after birth when their newborns were 33.9 weeks corrected age compared to 63 days and 47.7 weeks among community-based donors. The overall median volume of DHM per donor was 14.4 L over a period of 46 days. The amount and duration were higher in community-based donors (17.5 L in 72 days, 300 ml/day) than those in the hospital (8.4 L in 30 days, 258 ml/day). More than 37% of donors contacted the HMB themselves; the remainder were introduced by health professionals. Factors associated with higher volumes of DHM included higher education (OR: 1.77; 95% CI: 1.09, 2.87), having a full-term newborn (OR: 2.46; 95% CI: 1.46, 4.13), and community-based donors (OR: 2.15; 95% CI: 1.22, 3.78).ConclusionsMothers with higher education and from the community donate more breastmilk over a longer duration than those with lower education and from the hospital. Breastfeeding protection, promotion, and support should be offered to all mothers with specialized breastfeeding support for mothers of preterm and sick infants. This will ensure mothers have sufficient breastmilk for their newborns and potentially surplus breastmilk for donation.
Early life stress induces irritable bowel syndrome from childhood to adulthood in mice
Authors: Tao Enfu , Wu Yuhao , Hu Chenmin , Zhu Zhenya , Ye Diya , Long Gao , Chen Bo , Guo Rui , Shu Xiaoli , Zheng Wei , Zhang Ting , Jia Xinyi , Du Xiao , Fang Marong , Jiang Mizu 
Published: October 2023

BackgroundIrritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorder. Traditionally, early life stress (ELS) is predisposed to IBS in adult. However, whether ELS induces IBS in early life remains unclear.MethodsSeparated cohort studies were conducted in neonatal male pups of C57BL/6 mice by maternal separation (MS) model. MS and non-separation mice were scheduled to be evaluated for prime IBS-phenotypes, including visceral hypersensitivity, intestinal motility, intestinal permeability, and anxiety-like behavior. Ileal contents and fecal samples were collected and analyzed by 16S rRNA gene sequencing and bacterial community analyses. Subcellular structures of intestinal epithelial, such as epithelial tight junctions and mitochondria, were observed under transmission electron microscopy.ResultsMS induced visceral hypersensitivity and decreased total intestinal transit time from childhood to adulthood. In addition, MS induced intestinal hyperpermeability and anxiety-like behavior from adolescence to adulthood. Besides, MS affected intestinal microbial composition from childhood to adulthood. Moreover, MS disrupted intestinal mitochondrial structure from childhood to adulthood.ConclusionThe study showed for the first time that MS induced IBS from early life to adulthood in mice. The disrupted intestinal mitochondrial structure and the significant dysbiosis of intestinal microbiota in early life may contribute to the initiation and progress of IBS from early life to adulthood.
Association of aquaporin-4 antibody-seropositive optic neuritis with vision-related quality of life and depression
Authors: Song Ruitong , Huang Wenqiao , Yang Jun , Tang Xueshan , Huang Yihua , Chen Yingying , Zhao Mukun , Hu Qiuming , Du Yi 
Published: October 2023

ObjectiveAquaporin-4 (AQP4) antibody-seropositive optic neuritis (AQP4-ON) is one of the most common types of optic neuritis in China. However, the association between AQP4-ON and vision-related quality of life (QoL) and depression remains poorly understood.MethodsIn this cross-sectional study, 57 patients with optic neuritis were evaluated for their vision-related QoL using a Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and assessed for depressive symptoms using a Chinese version of the Beck Depression Inventory-II (BDI-II). Data regarding participants’ age, sex, visual acuity, and the number of recurrence events were gathered. Linear regression analysis was employed to investigate the relationships between AQP4-ON and vision-related QoL, as well as depression.ResultsOf the 57 included patients, 28 were AQP4-ON, and 29 were idiopathic optic neuritis (ION). AQP4-ON demonstrated a significant correlation with a decreased VFQ-25 composite score (Mean difference, −11.65 [95% CI, −21.61 to −1.69]; p = 0.023) and an increased BDI-II score (Mean difference, 6.48 [95% CI, 0.25 to 12.71]; p = 0.042) when compared to ION. The BDI-II score was correlated with the VFQ-25 composite score (Spearman ρ = −0.469; p &lt; 0.001) but not with the visual acuity in the worse-seeing eye (Spearman ρ = 0.024; p = 0.860) or in the better-seeing eye (Spearman ρ = −0.039; p = 0.775), bilateral severe visual impairment (Spearman ρ = 0.039; p = 0.772) or the number of recurrence events (Spearman ρ = 0.184; p = 0.171).ConclusionAQP4-positive optic neuritis is associated with a decline in vision-related quality of life as well as an increased likelihood of experiencing depression. It is crucial for clinicians to assess both vision-related QoL and depression in patients with AQP4-positive optic neuritis to provide patient-centered care.
Generation of synthetic EEG data for training algorithms supporting the diagnosis of major depressive disorder
Authors: Carrle Friedrich Philipp , Hollenbenders Yasmin , Reichenbach Alexandra 
Published: October 2023

IntroductionMajor depressive disorder (MDD) is the most common mental disorder worldwide, leading to impairment in quality and independence of life. Electroencephalography (EEG) biomarkers processed with machine learning (ML) algorithms have been explored for objective diagnoses with promising results. However, the generalizability of those models, a prerequisite for clinical application, is restricted by small datasets. One approach to train ML models with good generalizability is complementing the original with synthetic data produced by generative algorithms. Another advantage of synthetic data is the possibility of publishing the data for other researchers without risking patient data privacy. Synthetic EEG time-series have not yet been generated for two clinical populations like MDD patients and healthy controls.MethodsWe first reviewed 27 studies presenting EEG data augmentation with generative algorithms for classification tasks, like diagnosis, for the possibilities and shortcomings of recent methods. The subsequent empirical study generated EEG time-series based on two public datasets with 30/28 and 24/29 subjects (MDD/controls). To obtain baseline diagnostic accuracies, convolutional neural networks (CNN) were trained with time-series from each dataset. The data were synthesized with generative adversarial networks (GAN) consisting of CNNs. We evaluated the synthetic data qualitatively and quantitatively and finally used it for re-training the diagnostic model.ResultsThe reviewed studies improved their classification accuracies by between 1 and 40% with the synthetic data. Our own diagnostic accuracy improved up to 10% for one dataset but not significantly for the other. We found a rich repertoire of generative models in the reviewed literature, solving various technical issues. A major shortcoming in the field is the lack of meaningful evaluation metrics for synthetic data. The few studies analyzing the data in the frequency domain, including our own, show that only some features can be produced truthfully.DiscussionThe systematic review combined with our own investigation provides an overview of the available methods for generating EEG data for a classification task, their possibilities, and shortcomings. The approach is promising and the technical basis is set. For a broad application of these techniques in neuroscience research or clinical application, the methods need fine-tuning facilitated by domain expertise in (clinical) EEG research.
Targeting M-MDSCs enhances the therapeutic effect of BNCT in the 4-NQO-induced murine head and neck squamous cell carcinoma model
Authors: Chang Chun-Hsiang , Chen Chi-Jui , Yu Ching-Fang , Tsai Hui-Yu , Chen Fang-Hsin , Chiang Chi-Shiun 
Published: October 2023

PurposeMalignant head and neck squamous cell carcinoma (HNSCC) is characterized by a poor prognosis and resistance to conventional radiotherapy. Infiltrating myeloid-derived suppressive cells (MDSCs) is prominent in HNSCC and is linked to immune suppression and tumor aggressiveness. This study aimed to investigate the impact of boron neutron capture therapy (BNCT) on the MDSCs in the tumor microenvironment and peripheral blood and to explore the potential for MDSCs depletion combined with BNCT to reactivate antitumor immunity.Methods and materialsCarcinogen, 4-NQO, -induced oral tumors were irradiated with a total physical dose of 2 Gy BNCT in Tsing Hua Open Reactor (THOR). Flow cytometry and immunohistochemistry accessed the dynamics of peripheral MDSCs and infiltrated MDSCs within the tumor microenvironment. Mice were injected with an inhibitor of CSF-1 receptor (CSF-1R), PLX3397, to determine whether modulating M-MDSCs could affect mice survival after BNCT.ResultsPeripheral CD11b+Ly6ChighLy6G- monocytic-MDSCs (M-MDSCs), but not CD11b+Ly6CloLy6Ghigh polymorphonuclear-MDSCs (PMN-MDSCs), increased as tumor progression. After BNCT treatment, there were temporarily decreased and persistent increases of M-MDSCs thereafter, either in peripheral blood or in tumors. The administration of PLX-3397 hindered BNCT-caused M-MDSCs infiltration, prolonged mice survival, and activated tumor immunity by decreasing tumor-associated macrophages (TAMs) and increasing CD8+ T cells.ConclusionM-MDSCs were recruited into 4-NQO-induced tumors after BNCT, and their number was also increased in peripheral blood. Assessment of M-MDSCs levels in peripheral blood could be an index to determine the optimal intervention window. Their temporal alteration suggests an association with tumor recurrence after BNCT, making M-MDSCs a potential intervention target. Our preliminary results showed that PLX-3397 had strong M-MDSCs, TAMs, and TIL (tumor-infiltrating lymphocyte) modulating effects that could synergize tumor control when combined with BNCT.
Rhabdomyolysis associated with newer-generation anti-seizure medications (ASMs): a real-world retrospective and pharmacovigilance study
Authors: Deng Zhenzhen , Wang Shengfeng , Wu Cuifang 
Published: October 2023

Objective: Rhabdomyolysis is a potentially fatal adverse reaction mostly triggered by certain medications. Few real-world studies have shown a clear association between newer-generation anti-seizure medications (ASMs) and rhabdomyolysis. We sought to quantify the risk and evaluate the clinical features and management of rhabdomyolysis associated with newer-generation ASMs.Methods: Data were retrieved from the US FDA Adverse Event Reporting System database (FAERS) from 2018 to 2022 on newer-generation ASMs to identify rhabdomyolysis events, and disproportionality analyses were conducted by estimating the reporting odds ratios (RORs) and corresponding 95% confidence intervals (CIs). Furthermore, case reports from 2012 to 31 December 2022 on newer-generation ASMs-induced rhabdomyolysis were retrieved for retrospective analysis.Results: A total of 1,130 rhabdomyolysis reports from the FAERS database were considered. Levetiracetam had the greatest proportion and the highest positive signal values of rhabdomyolysis. The RORs (95% CIs) for newer-generation ASMs were, in descending order, levetiracetam 8.01 (7.26–8.84), lamotrigine 3.78 (3.25–4.40), oxcarbazepine 3.47 (2.53–4.75), pregabalin 2.75 (2.43–3.12), lacosamide 1.85 (1.29–2.65), topiramate 1.64 (1.25–2.15), and gabapentin 1.32 (1.13–1.55). Twenty-six case reports showed evidence of rhabdomyolysis, and levetiracetam (65.4%) was the most frequently reported agent. The median age was 32 years; typical initial symptoms included muscle weakness (34.8%), myalgia (34.8%), backache (17.4%), fatigue (13.0%) and leg pain (8.7%). The median time to onset of rhabdomyolysis was 2 days. All cases had elevated creatine phosphokinase (CPK), and some cases were accompanied by elevated creatinine (57.1%) and myoglobinuria (53.8%). Cessation of ASMs could lead to complete clinical remission. The median time for creatine phosphokinase (CPK) normalization was 8 days.Conclusion: This study identified 7 newer-generation ASMs with significant rhabdomyolysis reporting associations. Prescribers should be more aware of this risk and teach patients to recognize rhabdomyolysis signs/symptoms early.