bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of the Impact of Resveratrol on Viral
Hepatitis and Chronic Viral Hepatitis-related Hepatocellular
Carcinoma
Authors: Darvishi Mohammad , Nouri Majid , Rahimi Rasoul , Heidari-Soureshjani Saeid , Hashemi Rafsanjani Seyed Mahmood Reza 
Published: February 2024

Background::
Resveratrol (RSV) is used for the treatment of various
diseases due to their anti-inflammatory and antioxidant activities. However, its
beneficial aspects on viral hepatitis have been less investigated.

Objective::
This report reviews the impact of resveratrol on viral hepatitis and chronic
viral hepatitis-related hepatocellular carcinoma (HCC).

Methods::
The systematic review was performed and reported according to the
PRISMA 2020 statement. Several core databases, such as Cochrane Library,
PubMed, Web of Science, EMBASE, and Scopus, were used for search on September
6, 2023. After extraction of the data, the desired information of the full text of the
studies was recorded in Excel, and the outcomes and mechanisms were reviewed.

Results::
RSV inhibits viral replication through anti-HCV NS3 helicase activity,
maintains redox homeostasis via glutathione (GSH) synthesis, improves T and B cell
activity, and suppresses miR-155 expression. It also enhances viral replication by
enhancing hepatitis C virus (HCV) RNA transcription, activating sirtuin-1 (SIRT1),
which can increase peroxisome proliferator-activated receptor (PPAR), and SIRT1
activates the HBV X protein (HBx). Moreover, RSV is responsible for hepatitis-related
HCC proliferation via suppression of mammalian target of rapamycin (mTOR), SIRT1
up-regulation, inhibiting expression of HBx, and reducing expression of cyclin D1.

Conclusion::
Despite the promising properties of RSV in inhibiting hepatitis-related
HCC cell proliferation, its antiviral effects in viral hepatitis are controversial. The antihepatitis
behaviors of RSV are mainly dose-dependent, and in some studies, activating
some hepatoprotective pathways increases the transcription and replication of chronic
HBV and HCV. Therefore, healthcare providers should be aware of viral hepatitis
before using RSV supplements.
Volatomics-Assisted Characterization of Flavor Contributors During
Ripening of Wallace Melon (Cucumis melo L.)
Authors: Yin Hao , Jiang Yongli , Zhong Yu , Wang Danfeng , Liu Cong , Wang Ji-Li-Te , Zhang Minyan , Zhang Chunrong , Deng Yun 
Published: February 2024

Background:
Wallace melon has a powerful, pleasant aroma when ripe. However, little
is understood about the aroma profile and the Volatile Organic Compounds (VOCs) biosynthesis
during ripening.

Objective:
The aim of this study is to investigate the metabolome and transcriptome of Wallace
melon to study the mechanism underlying its aroma formation systematically.

Methods:
HS-SPME/GC-MS and RNA-Seq were used to analyze the VOCs and associated genes
of Wallace melon from three developmental stages (i.e., green, transition, and yellow stages).

Results:
The aroma profiles included 47 VOCs, which were in connection with 35 genes. Yellow-stage fruits are more aromatic than the melons in the transition and green stages, producing
higher concentrations of total VOCs (2994.36 ng/g), with ethyl acetate (543.16 ng/g) being the
most abundant compound. Transcriptomic analysis revealed that the biosynthesis of VOCs was
mainly related to fatty acid and amino acid metabolisms. Moreover, the lipoxygenase-1
(MELO3C014482.2), alcohol dehydrogenase-2 (MELO3C017100.2), 3-ketoacyl-CoA synthase-3
(MELO3C010941.2), and hydroperoxide dehydratase (MELO3C018412.2) genes were closely related to alcohols/esters through correlation analysis.

Conclusion:
The information generated will deepen the understanding of Wallace melon storage
quality and guide melon product development.
Patient and Staff Experience of Remote Patient Monitoring—What to Measure and How: Systematic Review
Authors: Pannunzio Valeria , Morales Ornelas Hosana Cristina , Gurung Pema , van Kooten Robert , Snelders Dirk , van Os Hendrikus , Wouters Michel , Tollenaar Rob , Atsma Douwe , Kleinsmann Maaike 
Published: February 2024

Background
Patient and staff experience is a vital factor to consider in the evaluation of remote patient monitoring (RPM) interventions. However, no comprehensive overview of available RPM patient and staff experience–measuring methods and tools exists.

Objective
This review aimed at obtaining a comprehensive set of experience constructs and corresponding measuring instruments used in contemporary RPM research and at proposing an initial set of guidelines for improving methodological standardization in this domain.

Methods
Full-text papers reporting on instances of patient or staff experience measuring in RPM interventions, written in English, and published after January 1, 2011, were considered for eligibility. By “RPM interventions,” we referred to interventions including sensor-based patient monitoring used for clinical decision-making; papers reporting on other kinds of interventions were therefore excluded. Papers describing primary care interventions, involving participants under 18 years of age, or focusing on attitudes or technologies rather than specific interventions were also excluded. We searched 2 electronic databases, Medline (PubMed) and EMBASE, on February 12, 2021.We explored and structured the obtained corpus of data through correspondence analysis, a multivariate statistical technique.

Results
In total, 158 papers were included, covering RPM interventions in a variety of domains. From these studies, we reported 546 experience-measuring instances in RPM, covering the use of 160 unique experience-measuring instruments to measure 120 unique experience constructs. We found that the research landscape has seen a sizeable growth in the past decade, that it is affected by a relative lack of focus on the experience of staff, and that the overall corpus of collected experience measures can be organized in 4 main categories (service system related, care related, usage and adherence related, and health outcome related). In the light of the collected findings, we provided a set of 6 actionable recommendations to RPM patient and staff experience evaluators, in terms of both what to measure and how to measure it. Overall, we suggested that RPM researchers and practitioners include experience measuring as part of integrated, interdisciplinary data strategies for continuous RPM evaluation.

Conclusions
At present, there is a lack of consensus and standardization in the methods used to measure patient and staff experience in RPM, leading to a critical knowledge gap in our understanding of the impact of RPM interventions. This review offers targeted support for RPM experience evaluators by providing a structured, comprehensive overview of contemporary patient and staff experience measures and a set of practical guidelines for improving research quality and standardization in this domain.
Perbandingan Uji Tekan pada Beton Dengan Menggunakan Sulfur Capping ( Belerang ) dan Alat Ribber Capping ( Plat Karet)
Authors: Susilo Hendro , Prasetyo Yudha , Suryani Made Yuri 
Published: February 2024

Beton merupakan material campuran yang terdiri dari agregat kasar, pasir dan semen serta air. Kuat tekan beton sangat dipengaruhi oleh unsur material penyusunnya diantaranya agregat kasar, agregat halus, semen dan air. Namun kuat uji tekan beton juga dipengaruhi oleh permukaan beton itu sendiri. Metode yang digunakan di dalam penelitian ini adalah capping beton menggunakan sulfur dan capping dengan metode rubber. Tujuan dari penelitian ini untuk menganalisis perbandingan uji kuat tekan beton terhadap pengujian kuat tekan beton dilaboratorium. Metode yang digunakan di dalam penelitian ini adalah dengan capping belerang dan alat rubber capping sehingga data pengujian yang dihasilkan dapat memenuhi standar beton normal f’c 25. Nilai kuat beton dilakukan dengan menggunakan mesin UTM Controls di Laboratorium Terpadu ITK. Pengujian kuat tekan mutu beton nantinya akan dilakukan masing-masing terdiri dari 2 sampel yang telah di capping belerang dan penggunaan alat rubber caping dengan usia beton 7 hari, 14 hari dan 28 hari. Sedangkan rancangan untuk campuran beton (Mix Design) mengunakan metode SNI. zzzxxcvc capping sulfur dan metode Rubber Plat didapatkan hasil persentase 59,94% pada mutu kuat tekan F’c 25 MPa. Hal ini menunjukan bahwa Caping Rubber mengalami peningkatan yang baik apabila dibandingkan dengan beton tanpa caping dan beton dengan caping sulfur.
Integrasi Termometer dalam Otomatisasi Hand Sanitizer Berbasis Arduino Uno
Authors: Priyo istiyono Yogi , Murdiono Murdiono 
Published: February 2024

Every day-to-day activity the hands are often contaminated with viruses, so the hands intermediary the entry of viruses into the body that cause a disease. One of the efforts to prevent or reduce the spread of the Covid-19 Virus is to wash their hands more diligently, but it is not uncommon for someone to ignore it by washing their hands. So an automatic Hand Sanitizer tool was designed which is equipped with an automatic body temperature check, using the LM35 temperature sensor as a body temperature detector, a DC Servo Motor drive as a pressure giver to the Hand Sanitizer, as well as using a Solenoid door lock to lock the door and Arduino UNO as the microcontroller for its control with the display on this LCD aims to reduce the spread of the Covid-19 Virus by checking human body temperature and washing hands with Hand Sanitizer automatically and creating an integrated system of automatic doors, washing hands, and automatic doors to prevent the spread of the corona virus by checking body temperature using an LM35 sensor. If a person's body temperature is below 37 oC then the Hand Sanitizer will automatically release liquid, then the door lock solenoid door lock will activate and the door lock will open.
Pengaruh Latihan Small Side Game terhadap Keterampilan Dribbling Pemain SSB PSG Situjuah Gadang
Authors: Ilham Ilham , Yulifri Yulifri , Rasyid Willadi , Saputra Mardepi 
Published: February 2024

Masalah penelitian adalah kurangnya keterampilan dribbling Pemain SSB PSG Situjuah Gadang Kecamatan Situjuah Limo Nagari. Penelitian ini bertujuan untuk mengetahui pengaruh latihan small side game terhadap keterampilan dribbling Pemain SSB PSG Situjuah Gadang Kecamatan Situjuah Limo Nagari. Jenis penelitian ini adalah penelitian eksperimen semu. Populasi dalam penelitian ini adalah pemain SSB PSG Situjuah Gadang Kecamatan Situjuah Limo Nagari Kabupaten Lima Puluh Kota yang mengikuti latihan berjumlah 59 orang. Teknik pengambilan sampel adalah dengan teknik purposive sampling, maka sampel penelitian ini berjumlah 20 orang. Instrumen dalam penelitian ini menggunakan dribbling test untuk mengukur keterampilan dribbling. Analisa data dan pengujian hipotesis menggunakan teknik analisis komparasi dengan menggunakan rumus uji beda mean (uji t) dengan taraf signifikan α = 0,05. Dari analisis data yang dilakukan diperoleh hasil : “Terdapat pengaruh latihan small side game terhadap peningkatan keterampilan dribbling pemain SSB PSG Situjuah Gadang Kecamatan Situjuah Limo Nagari, dengan perolehan koefisien uji “t” yaitu thitung = 10,60 > ttabel = 1,729.”
Pengaruh Latihan Plyometrics terhadap Peningkatan Daya Ledak Otot Tungkai Pemain Futsal SMA Negeri 9 Bengkulu Utara
Authors: Saputra Illyas Arib , Syampurma Hilmainur , Deswandi Deswandi , Arsil Arsil 
Published: February 2024

Penelitian ini bertujuan melihat pengaruh latihan plyometrics terhadap peningkatan daya ledak otot tungkai pemain futsal SMA Negeri 9 Bengkulu Utara. Jenis penelitian ini adalah eksperimen semu. Populasi dalam penelitian ini adalah seluruh pemain futsal SMA N 9 Bengkulu Utara yang berjumlah 16 orang. Teknik penarikan sampel yaitu purposive sampling. Sampel pada penelitian ini adalah 16 orang. Instrument penelitian menggunakan tes standing board jump. Teknik analisis data statistik menggunakan uji normalitas liliefors dan uji-t dengan taraf signifikan ɑ=0,05. Hasil penelitian ini adalah Terdapat pengaruh latihan plyometrics terhadap peningkatan daya ledak otot tungkai pemain futsal SMA N 9 Bengkulu Utara dengan skor rata-rata 1,74 m pada pre test, dan skor rata-rata 2,40 m pada post test. Hal ini terbukti secara signifikan, dimana setelah dilakukan uji “t” diperoleh hasil thitung = 11,66 > ttabel = 1,753 dengan persentase peningkatan 37,54%. Jadi, Ho di tolak sedangkan Ha diterima. Kesimpulan, terdapat pengaruh yang signifikan dari latihan plyometrics terhadap peningkatan daya ledak otot tungkai.
Tinjauan Teknik Dasar Dalam Permainan Bolabasket Ekstrkurikuler Putra SMA N 1 Sungai Rumbai di Kabupaten Dharmasraya
Authors: Pernando Yandhi , Neldi Hendri 
Published: February 2024

Masalah dalam penelitian ini adalah belum diketahuinya tingkat kemampuan teknik dasar shooting, dribbling, passing bolabasket putra SMA N 1 Sungai Rumbai Kabupaten Dharmasraya. Tujuan penelitian ini adalah untuk mengetahui tingkat kemampuan teknik dasar shooting, dribbling, passing bolabasket putra SMA N 1 Sungai Rumbai Kabupaten Dharmasraya. Jenis penelitian ini adalah penelitian deskriptif. Populasi dalam penelitian ini adalah seluruh pemain bolabasket SMA N 1 Sungai Rumbai Kabupaten Dharmasraya yang berjumlah 20 orang. Teknik pengambilan sampel menggunakan teknik total sampling, maka jumlah sampel dalam penelitian ini adalah sebanyak 20 orang. Instrument yang digunakan dalam penelitian ini dengan menggunakan tes kemampuan shooting, passing dan dribbling. Teknik analisis data menggunakan analisis deskriptif persentatif. Hasil penelitian ini adalah 1) Kemampuan teknik dasar passing pada bolabasket putra SMA N 1 Sungai Rumbai Kabupaten Dharmasraya memiliki rata-rata passing dengan kategori sedang. 2) Kemampuan teknik dasar dribbling pada bolabasket putra SMA N 1 Sungai Rumbai Kabupaten Dharmasraya memiliki rata-rata passing dengan kategori sedang. 3) Kemampuan teknik dasar shooting pada bolabasket putra SMA N 1 Sungai Rumbai Kabupaten Dharmasraya memiliki rata-rata passing dengan kategori sedang. 4) Secara keseluruhan kemampuan teknik dasar bolabasket putra SMA N 1 sungai rumbai kabupaten dharmasraya memiliki rata-rata berada pada kategori sedang.
Pengaruh Latihan Plyometrics Terhadap Daya Ledak Otot Tungkai Pada Atlet Putra Club Bolavoli Povkar Di Lengayang Kabupaten Pesisir Selatan
Authors: Fadhil Muhammad , Sepriadi Sepriadi 
Published: February 2024

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengaruh latihan plyometric terhadap daya ledak otot tungkai pada atlet putra club bolavoli Povkar di Lengayang Kabupaten Pesisir Selatan. Jenis penelitian ini adalah eksperimen semu dengan menggunakan one grup pretest-posttest design. Populasi dalam penelitian ini adalah semua atlet putra club bolavoli Povkar di Lengayang Kabupaten Pesisir Selatan Padang yaitu berjumlah 14 orang. Sampel dalam penelitian ini berjumlah 14 orang dengan menggunakan teknik sensus sampling. Data daya ledak otot tungkai dilakukan dengan test vertical jump. Teknik analisis data menggunakan teknik analisis uji-t dengan taraf singnifikansi α = 0,05.Hasil penelitian menunjukan terdapat peningkatan singnifikan rata rata daya ledak otot tungkai atlet yaitu pre- test (90,07) menjadi (95,62) pada post-test dan dimana thitung t hitung (3,121) > t tabel (1,782). Maka terdapat pengaruh metode latihan plyometric terhadap daya ledak otot tungkai pada atlet putra club bolavoli Povkar di Lengayang Kabupaten Pesisir Selatan.
Efektivitas Dosis dan Waktu Aplikasi Pupuk Kompos Trico-Glio untuk Pengendalian Penyakit Layu Fusarium (Fusarium sp.) pada Tanaman Cabai Merah (Capsicum annum L.)
Authors: Susanna Susanna , Alfizar Alfizar , Fitriadi Eka 
Published: February 2024

Fusarium sp. merupakan salah satu patogen tular tanah penyebab penyakit pada tanaman cabai merah yang dapat menimbulkan kerugian hingga 80%. Salah satu alternatif pengendalian yang dapat dilakukan yaitu menggunakan pupuk kompos yang mengandung agens antagonis Trichoderma sp. dan Gliocladium sp. Penelitian ini bertujuan untuk menentukan dosis dan waktu aplikasi pupuk kompos Trico-Glio (formulasi dengan bahan aktif Trichoderma sp. dan Gliocladium sp.) dalam mengendalikan penyakit layu fusarium (Fusarium sp.) pada tanaman cabai merah. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial. Faktor pertama yaitu dosis kompos Trico-Glio yang terdiri dari 5 taraf yaitu 0, 25, 50, 75, dan 100 g/tanaman dan faktor kedua waktu aplikasi terdiri dari 2 taraf yaitu 7 dan 14 hari sebelum tanam, sehingga terdapat 10 kombinasi perlakuan dan diulang 4 kali. Setiap unit perlakuan terdiri dari 4 tanaman sampel, maka diperoleh 160 unit percobaan. Peubah yang diamati meliputi masa inkubasi, insidensi penyakit, dan kepadatan populasi awal dan akhir mikroba (cendawan patogen dan agens antagonis). Hasil analisis ragam menunjukkan bahwa tidak terdapat pengaruh interaksi antara dosis dan waktu aplikasi pupuk kompos Trico-Glio terhadap masa inkubasi, insidensi penyakit, panjang diskolorasi xylem dan kepadatan populasi awal dan akhir mikroba. Namun secara mandiri dosis pupuk kompos Trico-Glio berpengaruh nyata terhadap semua peubah, sedangkan waktu aplikasi tidak berpengaruh nyata. Perlakuan 100 g/tanaman dari pupuk kompos Trico-Glio memperlihatkan hasil yang paling baik dalam mengendalikan penyakit layu fusarium pada tanaman cabai merah.
Uji Peningkatan Perkecambahan dan Vigor Benih Padi Varietas Junjuang dengan Isolat Trichoderma spp. Indigenous
Authors: Elita Nelson , Susila Eka , Sari Deliana Andam , Illahi Ayu Kurnia 
Published: February 2024

Budidaya padi dengan metode System of Rice Intensification (SRI) menggunakan bibit muda berumur 8-12 hari saat penanaman di lapangan. Bibit padi muda bermasalah ketika ditransplantasikan ke lapangan karena rentan kerusakan, penyakit dan stres lingkungan. Peningkatan kekuatan dan kesehatan kecambah padi dilakukan dengan memanfaatkan mikroba Plant Growth Promoting Fungi (PGPF) yaitu jamur Trichoderma spp. Tujuan penelitian ini adalah memperoleh isolat Trichoderma spp. indigenous yang memiliki kemampuan meningkatkan kualitas perkecambahan dan vigor benih padi verietas Junjuang. Metode penelitian menggunakan Rancangan Acak Lengkap dengan tujuh perlakuan Trichoderma spp. yaitu T0 = kontrol, T1 = Trichoderma sp. asal rumpun varietas Ketan Merah, T2 = Trichoderma sp. asal varietas Pandan Wangi, T3 = Trichoderma sp. asal varietas Junjuang, T4 = Trichoderma sp. asal varietas Cisokan, T5 = Trichoderma sp. asal varietas Kuning Kuriak, dan T6 = Trichoderma sp. asal varietas Siliah Baganti. Hasil penelitian menunjukkan bahwa panjang tunas, berat tunas, panjang akar, berat varietas Junjuang lebih sesuai dengan benih varietas Junjuang. Aplikasi isolat Trichoderma spp. pada perkecambahan benih dapat meningkatkan daya kecambah benih dibandingkan dengan kontrol.
What do veterinary professionals and clients want? Using discrete choice methods in veterinary research to determine preferences
Authors: Groves Catherine N. H. , Coe Jason B. , Grant Lauren E. 
Published: February 2024

Abstract
Discrete choice methods (DCMs) are a suite of research techniques for identifying individual preferences using choice information. Widely utilized by other fields yet rarely employed in veterinary research, DCMs have tremendous potential to improve veterinary healthcare by understanding and incorporating owner and veterinary professionals' (encompassing veterinarians, veterinary clinicians, technicians, receptionists, attendants, etc) preferences to optimize the care continuum. DCMs have several advantages over other stated preference methods, such as ranking and ratings, including improved data quality and actionability. However, they are not a panacea, and limitations that may affect DCMs' application to the veterinary field are outlined alongside realistic mitigation strategies. The information provided aims to increase awareness of DCMs and their utility in veterinary research and encourage greater uptake as a more robust method for measuring preferences.
Distribution and Genotyping of Infectious Hematopoietic Necrosis Virus in Farmed Rainbow Trout and Autochthonous Salmonids in North Macedonia
Authors: Traјchovski Aleksandar , Djadjovski Igor , Krstevski Kiril , Hristovska Zagorka Popova , Nikolovski Martin , Rashikj Ljubica , Bozinovski Dimitar , Grujovska Angela , Vendramin Niccolò , Cuenca Argelia , Cvetkovikj Aleksandar 
Published: February 2024

Abstract
Infectious hematopoietic necrosis (IHN) is a common disease in the intensive production of salmonids. The IHN virus (IHNV) was isolated for the first time in North Macedonia in 2018. This study aimed to investigate the distribution and genotype of IHN in farmed rainbow trout and autochthonous salmonid fish in North Macedonia following the first detection. The samples were collected from 47 trout farms. Trout fry with or without clinical signs of IHN were selected as individual samples. Kidney, spleen, and heart were taken from each fish during the dissection. Three pooled samples were collected from each farm. A total of 141 pooled samples were collected: Rainbow trout (Oncorhynchus mykiss) n=127, Macedonian trout (Salmo macedonicus) n=11, and Ohrid trout (Salmo letnica) n=3. The virus was detected in 43 samples (30.50%): rainbow trout (n=40), Macedonian trout (n=2), and Ohrid trout (n=1). There were 18 (38.30%) positive fish farms. The MAKIHNV1 isolate from 2018 (MN641902) and the newly isolated virus shared a similarity of >99 and were placed in clade E-1 of European genogroup E. The IHN has spread throughout the country and is also present in the autochthonous salmonids.
Role of endoscopic ultrasound-guided fine needle aspiration biopsies in diagnosing pancreatic neoplasms in the paediatric population: experience from a tertiary center and review of the literature
Authors: Radulovic Maja Kebe , Brecelj Jernej , Gruden Andrej , Flezar Margareta Strojan 
Published: February 2024

Abstract

Background
Endoscopic ultrasound-guided fine needle aspiration biopsy (EUS FNAB) is a well established diagnostic method in adult patients, but is rarely used in the paediatric population. The Clinical Department of Gastroenterology at the University Clinical Centre Ljubljana and the Department of Cytopathology at the Institute of Pathology, Faculty of Medicine, University of Ljubljana, Slovenia, have been closely collaborating on EUS FNAB since the introduction in 2010. The aim of the study was to review the cases of EUS FNAB of pancreatic neoplasms in children.

Patients and methods
In the digital archive of the Institute of Pathology (IP), Faculty of Medicine (FM), University of Ljubljana (UL), we found 6 cases of EUS FNAB in children, 3 had EUS FNAB of the pancreas, 2 of whom had a cytopathologic diagnosis of a tumour. In the first case, the lesion was ultrasonographically solid, and the cell sample contained branching papillary structures surrounded by aggregates of small cells with nuclear grooves. In the second case, the lesion was ultrasonographically cystic, and predominantly necrosis was seen, with only single preserved cells. Positive nuclear reaction for β-catenin was found in both cases by immunohistochemical staining.

Results
In both cases, the cytopathological diagnosis of solid pseudopapillary neoplasm of the pancreas was made, the cases represent the totality of paediatric cases of pancreatic neoplasms from the Children’s Hospital Ljubljana since 2010. There were no adverse events during and after EUS FNAB. A histopathological examination of the tumour resection specimens confirmed the cytopathological diagnosis.

Conclusions
Our experience indicates that EUS FNAB is a safe and effective method for diagnosing pancreatic neoplasms in the pediatric population, as supported by the findings in the literature.