bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathogenic bacteria prevalence in cultured Nile tilapia in Southwest Mexico: A real‐time PCR analysis
Authors: Soto‐Rodriguez Sonia A. , Marrujo Lopez Francis I. , Aguilar‐Rendon Karla G. , Guzmán Rafael Hernández 
Published: January 2024

AbstractThe present study investigates molecular‐based PCR techniques to estimate the prevalence of fish pathogens in southwest Mexico where recurrent mortality in the tilapia cultures has been observed. Sample of internal organs and lesions of Nile tilapia were taken and analysed in 2018, 2019, 2020 and 2022 to detect bacterial pathogens using PCR. No samples were taken in 2021 due to the COVID‐19 pandemic. The real‐time PCR conditions were optimized to allow a qualitative reliable detection of the bacteria from fixed fish tissue. A total of 599 pond‐ and cage‐cultured tilapia from the southwestern Mexican Pacific (Guerrero, Oaxaca and Chiapas states) were analysed. In this tropical region, during 2018 and 2019 water temperatures of the tilapia cultures were generally with the optimal range to grow Nile tilapia, although extreme values were recorded on some farms. Most of the tilapia sampled were apparently healthy. No Francisella sp. was detected in any sample, and Staphylococcus sp. was the most prevalent (from 0% to 64%) bacteria from the three states over time. Low prevalence of Aeromonas sp. was found, from 0% to 4.3%, although the fish pathogen Aeromonas dhakensis was not detected. Sterptococcus iniae was only detected in Chiapas in 2019 at a low prevalence (1.4%), while the major tilapia pathogen S. agalactiae was detected at a high prevalence (from 0% to 59%) in the three Mexican states. This is the first detection of these pathogenic bacteria in rural farms using real‐time PCR and constitutes a great risk for tilapia aquaculture in Mexico, as well as a potential dispersion of these pathogens to other aquaculture areas.
Evidence‐based data for newly approved medications' use in older adults: An analysis from clinical trials to monographs
Authors: Gosselin Maude , Baroud Marie‐Laure , Denis Odélie‐Rose , Gagnon Marie‐Eve , Sirois Caroline 
Published: January 2024

AbstractBackgroundOlder adults have historically been excluded from clinical trials, limiting evidence‐based data. An updated picture of the situation with newly marketed medications is needed. We aimed to describe (1) the recommendations specific to older adults in monographs of newly marketed medications; (2) the representation of older adults in clinical trials of those medications.MethodsIn November 2020, we listed all medications that received a notice of compliance from Health Canada between January 2006 and September 2020, excluding those with indications irrelevant to community‐dwelling older adults and locally acting medications. We assessed the availability and clarity of recommendations in monographs regarding older adults. Using Clinicaltrials.gov, we identified randomized controlled double‐blind Phase III–IV trials led in Canada/United States of a sample of 30 commonly used medications among those previously listed. We extracted information on study design, participants, and efficacy/safety analysis specific to older patients. We used simple linear regression and Chi‐square/Fisher's exact tests to analyze time trends in the representation of older adults over different periods.ResultsA total of 195 monographs were included. Of the 130 monographs reporting a dosing recommendation in older adults, 53 (41%) also reported limited/insufficient data in this population or its subgroups. Of the 373 trials included, 217 (58%) did not integrate a maximum age as an inclusion criterion. However, only 113 (30%) reported including a proportion of older adults representative (or over‐representative) of the Canadian older population. Most trials (n = 289; 78%) did not provide efficacy or safety data specific to older adults. In our sample, the number/proportion of older adults in trials seemed to be increasingly reported over time, either explicitly or implicitly (e.g., inclusion criterion specifies <65 years old).ConclusionsNewly marketed medications still appear to under‐represent older adults. The resulting lack of clear recommendations in monographs compromises evidence‐based practice, thereby perpetuating the risk to older adults' health.
Being Aware of Death: How and when Mortality Cues Incite Leader Expediency Versus Servant Leadership Behaviour
Authors: Ogbonnaya Chidiebere , Babalola Mayowa T. , Ali Moazzam , Ren Shuang , Usman Muhammed , Wang Zhining 
Published: January 2024

AbstractThe COVID‐19 crisis has been associated with existential concerns regarding mortality. These concerns, described as ‘mortality cues’, can influence people's emotions, behaviours, and the quality of leadership in organizations. Using the contingency model of death awareness (CMDA; Grant and Wade‐Benzoni, 2009), we provide new evidence on how mortality cues can incite negative and positive leadership behaviours via two forms of death awareness: death anxiety and death reflection. Specifically, we theorize that mortality cues can increase leader death anxiety, giving rise to leader expediency (a leader's use of unethical practices to expedite work for self‐serving purposes); however, mortality cues can also facilitate leader death reflection and, consequently, servant leadership behaviour. We further suggest that leaders’ responses to mortality cues depend on their psychological capital (PsyCap), such that leaders with high (vs. low) PsyCap respond to mortality cues with less expediency (via death anxiety) and more servant leader behaviours (via death reflection). We support our hypotheses through three separate studies using an experiment, time‐lagged data from healthcare workers, and daily diary data from non‐healthcare professionals. We conclude that mortality cues have a double‐edged influence on leadership behaviour. We also discuss the theoretical and practical implications of the findings.
The evolutionary history and distribution of cactus germplasm resources, as well as potential domestication under a changing climate
Authors: Khan Darya , Harris AJ , Zaman Qamar U. , Wang Hong‐Xin , Wen Jun , Landis Jacob B. , Wang Hua‐Feng 
Published: January 2024

AbstractThe angiosperm family Cactaceae, a member of the Caryophyllales, is a large and diverse group of stem succulents comprising 1,438–1,870 species within approximately 130 genera predominantly distributed from northern Canada to Patagonia. Four centers of diversity from Central and North America (Chihuahua, Puebla‐Oaxaca, Sonora‐Sinaloan, and Jalisco) and three centers of diversity from South America (Southern Central Andes, Caatinga, and Mara Atlantica) have played a pivotal role in disbursing cacti around the globe. Mexico is considered the richest area in cacti species with close to 563 species grouped into 50 genera. Approximately 118 species have been domesticated by Mesoamerican people as food crops and for ornamental purposes. Cacti inhabit a wide range of ecosystems and climate regions, ranging from tropical to subtropical and from arid to semiarid regions. Species belonging to the genus Opuntia are the major food crop producers in the family. Cacti have derived characteristics from familial synapomorphies within the Caryophyllales. Reproduction occurs through pollination facilitated by birds, bats, bees, and other insects. Climate variability, whether natural or human‐induced threatens global crop production including high temperatures, salinity, drought, flood, changes in soil pH, and urbanization. Cacti have several adaptations that are important for coping with abiotic stresses, such as crassulacean acid metabolism (CAM photosynthesis), as well as modifications to root and stem physiological pathways. This review aims to provide a comprehensive view of the fruit crops in Cactaceae, including their evolution, worldwide distribution, and the environmental factors impacting cultivation.
Coincidence: A word with two meanings for explaining and predicting the future
Authors: Archer Margaret S. 
Published: January 2024

AbstractConnecting the critical realist morphogenetic model to insights made by Nicholas Rescher, this paper argues that our predictions are always subject to chance and contingency but nevertheless ineluctably useful for both practical and scientific inquiry. Contingency results from the causal openness of the world, including the causal openness of our own decision‐making. On the other hand, as Rescher notes, human interaction would fail without a degree of stability, which makes the predictions of morphostatic relations if not lawlike at least predictable in a practical sense. Nor is it just habit that makes for morphostasis. Human agents strive reflectively to produce in morphostatic ways the human goods they have created by their interaction. And beyond individual actors, there is, from the critical realist point of view, the combined effects of structure and culture inclining at least in the short‐term to reliably predictable if not lawlike outcomes. With that background, the paper reflects on the dual role of coincidence in social theory, on the one hand signalling contingency and the other on what, according to the active causal mechanisms, generally co‐occur.
Factors associated with progression or non‐progression to bariatric surgery in adults: A systematic review
Authors: Majstorovic Mia , Chur‐Hansen Anna , Andrews Jane M. , Burke Anne 
Published: January 2024

SummaryAccess to bariatric surgery is limited, and the factors related to undergoing or not undergoing the procedure are poorly understood.To this end, a systematic review of PubMed, Embase, PsycINFO, and CINAHL was conducted to deduce the factors associated with progression or non‐progression to bariatric surgery. Quantitative and qualitative English‐language articles ranging in date from database conception to September 2023 were included. Eligible studies employed adult participants (18 years of age or above) who had been referred for bariatric surgery.A total of 57 studies were identified. Fifteen key factors were found, alongside six less frequently studied factors: age, sex, BMI, race and ethnicity, distance to clinic, socio‐economic status, insurance coverage, physical health, psychological health, eating history and habits, substance use and smoking, social influence and relationships, pre‐surgery process and requirements, surgery‐related concerns, choice of surgery, and others (emergency room visitation, COVID‐19 virus, health literacy, appearance perceptions, time‐off work, and stigma related to surgery).No factors were found to be reliably associated with progression or non‐progression to bariatric surgery; however, the nature of these findings is tentative considering methodological flaws and limited research. Further studies are required to elucidate potential inequities in bariatric surgery access and educate policymakers and health professionals.
Dexmedetomidine and magnesium sulfate in preventing junctional ectopic tachycardia after pediatric cardiac surgery
Authors: Hassan Passaint Fahim , El Haddad Ahmed M. 
Published: January 2024

AbstractBackgroundJunctional ectopic tachycardia (JET) is a serious tachyarrhythmia following pediatric cardiac surgery. It isn't easy to treat and better to be prevented. This study aimed to examine the prophylactic effects of dexmedetomidine, MgSO4, or their combination in reducing JET following pediatric open cardiac surgery.MethodsHundred and twenty children under 5 years, weighing more than 5 kg, who were scheduled for corrective acyanotic cardiac surgeries were randomized into three groups. Group MD (Dexmedetomidine–MgSO4 group): received dexmedetomidine 0.5 μg/kg IV over 20 min after induction, then infusion 0.5 μg/kg/h for 72 h, and 50 mg/kg bolus of MgSO4 with aortic cross‐clamp release, then continued administration for 72 h postoperatively at a dose of 30 mg/kg/day. Group D (the dexmedetomidine group) received the same dexmedetomidine as the MD group in addition to normal saline instead of MgSO4. Group C (control group): received normal saline instead of dexmedetomidine and MgSO4. The primary outcome was the detection of JET incidence; the secondary outcomes were hemodynamic parameters, ionized Mg, vasoactive‐inotropic score, extubation time, PCCU and hospital stay, and perioperative complications.ResultsThe incidence of JET was significantly reduced in Group MD and Group D (p = .007) compared to Group C. Ionized Mg was significantly higher in Group MD than in Groups D and C during rewarming and in the ICU (p < .001). Better hemodynamic profile in Group MD compared to Group D and Group C throughout surgery and in the ICU, the predictive indexes were significantly better in Group MD than in Groups D and C (p < .001). Including the extubation time, PCCU, and hospital stay.ConclusionDexmedetomidine alone or combined with MgSO4 had a therapeutic role in the prevention of JET in children after congenital heart surgery.
Understanding hypergammaglobulinemia in experimental or natural visceral leishmaniasis
Authors: de Carvalho Camila Aparecida , Hiramoto Roberto Mitsuyoshi , Meireles Luciana Regina , de Andrade Heitor Franco 
Published: January 2024

AbstractNonspecific hypergammaglobulinemia (HGG) occurs in symptomatic human visceral leishmaniasis (VL) caused by L. L. infantum. This study assessed this finding in experimental infection in hamsters and natural infection in dogs. The serum concentration of proteins, albumin and globulins was determined through the biuret and bromocresol green reaction, where the HGG was better expressed through the albumin/globulin (A/G) ratio. HGG was associated with a higher concentration of specific anti‐glycan antibodies (BSA‐G)/promastigote soluble extract (PSE) and the presence of circulating immune complexes (IC) by dissociative enzyme‐linked immunoassay (ELISA). The study found monovalent IC in 37.9% (PSE) and 50% (BSA‐G) of sera from infected hamsters, with increased frequency as the disease progressed. HGG was found in >60% of the samples in dogs with VL, associated with higher levels of specific immunoglobulin (Ig)A and IgM, but not IgG, determined using the PSE and BSA‐G ELISA. HGG was associated with the presence of monovalent IC in 58.9% (PSE) and 63.4% (BSA‐G) positive dog samples. HGG may result not only from the nonspecific activation of B cells, with greater production of specific and nonspecific antibodies, but also due to lower IgG excretion due to the presence of soluble monovalent IC. HGG correlates to the progression of VL and may be a marker for manifested disease.
Age‐related changes in the fiber structure around adipocytes in the subcutaneous fat layer and their association with skin viscoelasticity
Authors: Mizukoshi Koji , Kurosumi Motonori , Hamanaka Yoshihiro 
Published: January 2024

AbstractObjectiveAge‐related changes in the fiber structure around adipocytes were investigated via scanning electron microscopy (SEM) of excised skin tissues. In addition, the viscoelasticity of the subcutaneous fat layer was evaluated via elastography, and the association between the fiber structure and the viscoelastic properties was assessed.MethodsSkin tissues excised from the facial cheek area were used. Then, SEM images of these tissues were obtained. The thickness and quantity of the fibers around adipocytes were assessed using a 5‐point scale. The score was used to grade 18 tissue samples. Moreover, the viscoelasticity of the subcutaneous fat layer in the same samples was evaluated via ultrasound elastography.ResultsBased on the SEM image score, an association was observed between the fiber status score and age, thereby indicating a tendency toward age‐related fibrosis. Fiber structures with high scores, which indicate fibrosis, had a significantly lower viscoelasticity based on ultrasound elastography.ConclusionThe thickness and quantity of fibrous structures around adipocytes in the subcutaneous fat layer increase with age, and these changes can be associated with decreased viscoelasticity in the subcutaneous fat layer.
Queen of the Skies
Authors: Langston Lee S. 
Published: January 2024

Abstract
The event of the last 747 off the production line was marked by many retrospectives in the media. Virtually every one of them described an uneventful engineering success story. In actuality, the jetliner was cutting-edge technology when it was first developed and in need of some solid, thinking-on-your-feet engineering to make it fly.
Predicting Knee Joint Contact Forces During Normal Walking Using Kinematic Inputs With a Long-Short Term Neural Network
Authors: Bennett Hunter J. , Estler Kaileigh , Valenzuela Kevin , Weinhandl Joshua T. 
Published: January 2024

Abstract
Knee joint contact forces are commonly estimated via surrogate measures (i.e., external knee adduction moments or musculoskeletal modeling). Despite its capabilities, modeling is not optimal for clinicians or persons with limited experience. The purpose of this study was to design a novel prediction method for knee joint contact forces that is simplistic in terms of required inputs. This study included marker trajectories and instrumented knee forces during normal walking from the “Grand Challenge” (n = 6) and “CAMS” (n = 2) datasets. Inverse kinematics were used to derive stance phase hip (sagittal, frontal, transverse), knee (sagittal, frontal), ankle (sagittal), and trunk (frontal) kinematics. A long-short term memory network (LSTM) was created using matlab to predict medial and lateral knee force waveforms using combinations of the kinematics. The Grand Challenge and CAMS datasets trained and tested the network, respectively. Musculoskeletal modeling forces were derived using static optimization and joint reaction tools in OpenSim. Waveform accuracy was determined as the proportion of variance and root-mean-square error between network predictions and in vivo data. The LSTM network was highly accurate for medial forces (R2 = 0.77, RMSE = 0.27 BW) and required only frontal hip and knee and sagittal hip and ankle kinematics. Modeled medial force predictions were excellent (R2 = 0.77, RMSE = 0.33 BW). Lateral force predictions were poor for both methods (LSTM R2 = 0.18, RMSE = 0.08 BW; modeling R2 = 0.21, RMSE = 0.54 BW). The designed LSTM network outperformed most reports of musculoskeletal modeling, including those reached in this study, revealing knee joint forces can accurately be predicted by using only kinematic input variables.
A Study on the Oil Film Thickness Between the Lower Rail of Oil Control Ring and Lower Flank of Oil Control Ring Groove of an Engine
Authors: Miura Ken , Ito Akemi , Nakamura Yuta , Yamada Rina , Nishibe Koichi , Usui Miyuki , Iijima Naoki 
Published: January 2024

Abstract
Lubricating oil consumption (LOC) of engines causes particulate matter in exhaust gas and abnormal combustion like pre-ignition which becomes a serious problem in hydrogen engines. Lubricating oil transports upward into the combustion chamber of an engine via the sliding surface, the gap, and the side and back of a piston ring. The target of this study was to clarify the mechanism of oil flowing between an oil control ring lower flank and the groove which was the first entrance of lubricating oil supplied from the crankshaft. Oil film thickness at the lower flank of the oil control ring was measured by laser-induced fluorescence method using optical fibers embedded in the lower flank of the ring groove. The measured oil film thickness was compared with forces acting on the lower rail of three-piece type oil control ring. The oil film thickness change was well explained using those forces and it was found that friction force at the sliding surface and pressure in the ring groove were dominant on the oil film thickness under all operating conditions tested in this study.
Differences in Glenohumeral Joint Contact Forces Between Recovery Hand Patterns During Wheelchair Propulsion With and Without Shoulder Muscle Weakness: A Simulation Study
Authors: Walford Shelby L. , Rankin Jeffery W. , Mulroy Sara J. , Neptune Richard R. 
Published: January 2024

Abstract
The majority of manual wheelchair users (MWCU) develop shoulder pain or injuries, which is often caused by impingement. Because propulsion mechanics are influenced by the recovery hand pattern used, the pattern may affect shoulder loading and susceptibility to injury. Shoulder muscle weakness is also correlated with shoulder pain, but how shoulder loading changes with specific muscle group weakness is unknown. Musculoskeletal modeling and simulation were used to compare glenohumeral joint contact forces (GJCFs) across hand patterns and determine how GJCFs vary when primary shoulder muscle groups are weakened. Experimental data were analyzed to classify individuals into four hand pattern groups. A representative musculoskeletal model was then developed for each group and simulations generated to portray baseline strength and six muscle weakness conditions. Three-dimensional GJCF peaks and impulses were compared across hand patterns and muscle weakness conditions. The semicircular pattern consistently had lower shear (anterior-posterior and superior-inferior) GJCFs compared to other patterns. The double-loop pattern had the highest superior GJCFs, while the single-loop pattern had the highest anterior and posterior GJCFs. These results suggest that using the semicircular pattern may be less susceptible to shoulder injuries such as subacromial impingement. Weakening the internal rotators and external rotators resulted in the greatest increases in shear GJCFs and decreases in compressive GJCF, likely due to decreased force from rotator cuff muscles. These findings suggest that strengthening specific muscle groups, especially the rotator cuff, is critical for decreasing the risk of shoulder overuse injuries.
Variations in neonatal mortality of preterm infants with intraparenchymal haemorrhage in Europe: the EPICE cohort
Authors: Loth Charline , Treluyer Ludovic , Pierrat Véronique , EGO Anne , Aubert Adrien M , Debillon Thierry , Zeitlin Jennifer , Torchin Heloise , Chevallier Marie 
Published: January 2024

ObjectiveThe aim of this study was to investigate variations in mortality before neonatal intensive care unit (NICU) discharge of infants born preterm with intraparenchymal haemorrhage (IPH) in Europe with a special interest for withdrawing life-sustaining therapy (WLST).DesignSecondary analysis of the Effective Perinatal Intensive Care in Europe (EPICE) cohort, 2011–2012.SettingNineteen regions in 11 European countries.PatientsAll infants born between 24+0and 31+6weeks’ gestational age (GA) with a diagnosis of IPH.Main outcome measuresMortality rate with multivariable analysis after adjustment for GA, antenatal steroids and gender. WLST policies were described among NICUs and within countries.ResultsAmong 6828 infants born alive between 24+0and 31+6weeks’ GA and without congenital anomalies admitted to NICUs, IPH was diagnosed in 234 infants (3.4%, 95% CI 3.3% to 3.9%) and 138 of them (59%) died. The median age at death was 6 days (3–13). Mortality rates varied significantly between countries (extremes: 30%–81%; p<0.004) and most infants (69%) died after WLST. After adjustment and with reference to the UK, mortality rates were significantly higher for France, Denmark and the Netherlands, with ORs of 8.8 (95% CI 3.3 to 23.6), 5.9 (95% CI 1.6 to 21.4) and 4.8 (95% CI 1.1 to 8.9). There were variations in WLST between European regions and countries.ConclusionIn infants with IPH, rates of death before discharge and death after WLST varied between European countries. These variations in mortality impede studying reliable outcomes in infants with IPH across European countries and encourage reflection of clinical practices of WLST across European units.