bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pränatale Diagnose einer Trisomie 21: Einfluss der kinderärztlichen
Beratung Schwangerer und des Kontaktes zu Familien mit einem betroffenen
Kind
Authors: Kondakov Sandra , Faschingbauer Florian , Beckmann Matthias W. , Schneider Holm 
Published: January 2025

ZusammenfassungDer breite Einsatz nichtinvasiver Pränataltests
(NIPT) hat vorgeburtliche Diagnostik auf Chromosomenanomalien von der
Ausnahme zur Regel werden lassen. Ein häufiger Befund ist der Verdacht auf
eine Trisomie 21 des Fetus, der das Angebot fachübergreifender Beratung nach
sich ziehen sollte. Deren Bedeutung für die Entscheidungsfindung der
Schwangeren wurde bisher nicht untersucht.Vollständig anonymisierte Daten zur pädiatrischen
Beratung von 251 Schwangeren wegen unklarer NIPT-Befunde, Verdachts auf eine
fetale Trisomie 21 oder schon gesicherter Diagnose wurden retrospektiv
ausgewertet. Sämtliche Beratungen zum Thema Trisomie 21 in dieser Kohorte
waren durch denselben erfahrenen Kinderarzt erfolgt, der das Gespräch erst
beendete, wenn die Ratsuchenden keine Fragen mehr hatten, und stets anbot,
direkten Kontakt zu Familien zu vermitteln, in denen ein Kind mit Trisomie
21 lebt. Kontaktaufnahmen mit solchen Familien sowie der Ausgang der
Schwangerschaft wurden jeweils erfasst. Die Datenanalyse umfasste
deskriptive Statistik und geeignete statistische Tests. Relevant für die Entscheidung der Schwangeren
über die Fortsetzung oder den Abbruch der Schwangerschaft schienen
insbesondere der Zeitpunkt des pädiatrischen Beratungsgesprächs, dessen
Dauer sowie die Kontaktaufnahme zu Familien mit einem betroffenen Kind zu
sein.Bei Verdacht auf eine fetale Trisomie 21
ist zeitnahe und ausführliche pädiatrische Beratung sowie der Kontakt zu
Betroffenen von entscheidender Bedeutung.
Ergonomische Belastung des OP-Teams bei offenen, laparoskopischen sowie roboterassistierten Operationsverfahren
Authors: Koch Oliver Owen , Leberbauer Karoline , Hitzl Wolfgang , Wallner Eva , Emmanuel Klaus 
Published: January 2025

ZusammenfassungZiel dieser Arbeit ist es, die ergonomische Belastung des OP-Teams bei offenen, laparoskopischen sowie roboterassistierten Operationsverfahren (RC) zu untersuchen.Mitarbeiter der Salzburger Landeskliniken (SALK) wurden im Dezember 2023 zu einer standardisierten Onlinebefragung eingeladen. Die Ausprägung und die Unterschiede der psychophysischen Belastung für die einzelnen Berufsgruppen und Fachgebiete zwischen den unterschiedlichen Operationsverfahren wurde untersucht.Es nahmen 64/111 (57,7%) Mitarbeiter an der Studie teil, davon waren 30 (46,9%) männlich und 34 (53,1%) weiblich. Die Tätigkeit im OP ist für die Mehrheit der Befragten körperlich belastend, 60,9% der Befragten mussten bereits ärztliche Hilfe in Anspruch nehmen oder ein Schmerzmittel einnehmen. Die am häufigsten betroffen Körperregionen sind Rücken und Nacken, und 17,2% der Befragten halten es für wahrscheinlich, vorzeitig in den Ruhestand gehen zu müssen. Die Mehrheit empfindet Spaß an der Arbeit im OP. Für 61,9% wird die RC als am wenigsten körperlich belastend empfunden. Signifikante Unterschiede in psychophysischen Belastungen und bei Präferenzen für Operationsarten zeigten sich bei Geschlecht, Altersgruppen, Berufsgruppen, Fachgebieten, Arbeitsjahren im OP und biometrischen Daten.Diese Ergebnisse könnten dazu dienen, gezielt gesundheits- und mitarbeiterzufriedenheitsfördernde Maßnahmen einzuleiten und entsprechende Schulungen durchzuführen.
Managing Home Oxygen and Nasogastric Feeds Post-NICU Discharge: PCP Practices and Perspectives
Authors: Beard Lauren A. , Weikel Blair W. , Hannan Kathleen E. , Messinger Amanda I. , Bourque Stephanie L. 
Published: January 2025

Objective NICU graduates are frequently technology dependent including home oxygen, pulse oximetry, and/or nasogastric (NG) feedings. Primary care provider (PCP) perceptions, practices, and barriers to managing these infants are not well described, especially at altitude. We sought to 1) describe PCP comfort and 2) determine practices and barriers in managing this technology at higher altitudes.
Study Design This cross-sectional survey assessed Colorado and Wyoming PCP perceptions and practices surrounding technology in NICU graduates. We explored bivariate analysis between clinic altitude, location, and provider's experience with comfort caring for infants discharged with technology using chi-squared or Fisher's exact tests. Significant relationships were modeled using logistic regression for odds ratios and 95% confidence intervals.
Results Among 203 respondents, 82% were pediatricians, and 86% practiced in urban/suburban environments. Clinic altitude ranged 2,500–9,000 ft. PCPs endorsed comfort managing oxygen in term (92%) and moderately/late preterm infants (82%), versus 52% comfort in very/extremely preterm infants. 62% utilized an oxygen-weaning algorithm. Comfort managing oxygen was greater in suburban versus urban locations (odds ratio [OR] = 4.4, 95% confidence interval [CI]: 1.6–11.7) and providers practicing for >10 versus <5 years (OR = 3.5, 95% CI: 1.5, 8.4). 60% found pulse oximetry useful, though 70% perceived caregiver stress. 69% accepted infants on NG feeds, though 61% endorsed discomfort with management.
Conclusion PCPs are comfortable managing home oxygen in moderately preterm to term infants but find caring for most preterm infants challenging. Discomfort in managing NG feeds is prevalent. This highlights peridischarge barriers and improvement opportunities for high-risk, technology-dependent infants.
Key Points
Effects of additional scapular movements on the scapular muscle
activity during arm raising
Authors: Yu Ilyoung , Kang Minhyeok 
Published: January 2025

AbstractThe effects of the two popular strategies, scapular adduction and depression and
scapular posterior tilt, on the muscle activity of trapezius and serratus
anterior muscles have not been compared. This study demonstrates the effects of
additional scapular adduction and depression and scapular posterior tilt
movements on the activation of trapezius and serratus anterior muscles and
scapular kinematics during arm raising. Eighteen asymptomatic men performed arm
raising tasks with and without additional scapular movements, including scapular
adduction and depression and scapular posterior tilt. During all tasks, the
muscle activity of the upper/middle/lower trapezius and serratus anterior
muscles was measured using surface electromyography; scapular upward rotation
and posterior tilt angles were measured using a smartphone application. Lower
trapezius muscle activity significantly increased during arm raising with
scapular adduction and depression (p=0.001) or scapular posterior tilt
compared to preferred arm raising (p<0.001). However, arm raising with
the scapular posterior tilt showed significantly greater serratus anterior
muscle activity (p=0.002) and scapular posterior tilt angle
(p=0.001) together with lesser upper trapezius muscle activity
(p=0.027) compared with those of scapular adduction and depression.
Scapular posterior tilt may be effective for increasing the lower trapezius and
serratus anterior muscle activity while reducing the upper trapezius muscle
activity.
Percutaneous Biliary and Gallbladder Interventions: Where Should Interventional Radiology Be Headed?
Authors: Riaz Ahsun , Husnain Ali 
Published: January 2025

AbstractInterventional radiology (IR) has evolved significantly in the past three decades due to improvements in techniques and technologies. The role of IR in managing biliary and gallbladder disease is evolving. A factor that has influenced our ability to perform advanced procedures has been the progress in endoscopes and their availability to IR. In addition to urgent or emergent decompression for these tubular structures and hollow organs, IR can also perform definitive therapies such as stenting and lithotripsy. The main objective of our therapies should be to remove drains as quickly as possible to improve patients' quality of life. The evolution of IR's role in this space is ongoing and should focus beyond decompression on treating the disease and the patient.
Exploring the innovation potential of urban space at the micro scale: a case study of Suzhou’s main urban area
Authors: Wang Shumin , Liu Hao , Li Yingcheng , Hu Mingxing 
Published: January 2025

Abstract
As urban areas serve as spatial carriers for innovation activities, exploring the interaction between innovation and urban spaces has become a research hotspot. Previous studies have primarily focused on urban innovation capacity assessment and measurement, with less attention given to the urban innovation potential and issues such as insufficient granularity of research and weak stability in factor weighting. In this study, an urban spatial innovation potential measurement system was proposed from a demand-side perspective, the structural equation model (SEM) was employed to investigate the direct and indirect influences of factors, and micro-scale empirical analysis was conducted in the main urban area of Suzhou, China. Coupling and coordination with innovation outputs were analyzed. The results revealed that (1) the innovation potential exhibits significant spatial clustering characteristics; (2) there is clear core-periphery spatial differentiation in the innovation potential, demonstrating decreasing spatial diffusion effects with distance from the center; and (3) only 8.18% of the plots in the study area occur at the harmonized innovation coupling stage, indicating that the overall innovation conversion efficiency should be improved. This study aimed to provide a sound basis and practical references for optimizing the layout and improving the quality of urban innovation spaces from a detailed scale perspective, thereby enhancing urban competitiveness.
Introduction
Authors: Shelleg Assaf 
Published: January 2025

Abstract
Ruby Namdar’s 2013 novel The Ruined House is introduced as a literary equivalent to contemporary music in and about Israel. Much in the way the novel expropriates the many registers of the Hebrew language and relocates them outside the national soil, so do the composers featured in this book who employ similar registers and diasporic imports, but never as sites for the reproduction of ideology and territorialism. The introduction explores the Israeli and Jewish ecosystems that animate this book (in addition to the Actor-Network Theory at their base) while connecting them to the histories of modern music written by and about Jews. By reverting to diasporism, composers in Israel have come full circle with the manner by which modern Jewish composers had been unconditioned by territorialism. With indifference to and disinterestedness in the constituent tropes that have shaped Hebrew culture, both immigrant composers in Israel and their native born students defied the paradigmatic definition of Israeli art as a national territorial project—a project that exempted itself from the option of Jewish art existing outside Zionist temporality. And this is where the state of afterness emerges: it is the state of being unconditioned by territorialism while opting for previously unavailable spatial and temporal affordances that have been previously denied a modernist function in this cultural ecosystem.
Pnima
Authors: Shelleg Assaf 
Published: January 2025

Abstract
Chapter 2 is titled after Chaya Czernowin’s first opera Pnima . . . ins Innere (1998–1999), which draws its plot from David Grossman’s novel See Under: Love (1986). With Grossman’s dense literary text emptied out, Czernowin disnarrates the plot through sonic textures she transcribes from sounds previously translated into words by Grossman—all while effacing signifiers whose crippled imagery denationalize Holocaust memorialization. Chapter 2 features similar musical and literary examples that wrestle with the politicization of the Holocaust in Israel by Arik Shapira and Yishai Sarid. Shapira’s works feature blunt, machine-like vocal deliveries and other readymades that render grotesque the national pedagogy of the Holocaust in early statehood years, while Sarid’s novel (The Memory Monster) stages the emotional overload of such political distortions in the present. Still, while Czernowin writes under the purview of the contemporary global, Shapira is caught in the echo chamber of a national culture, squarely inverting symbolisms that betray the confines of his resistance. The second part of Chapter 2 unfolds the collapse of Jewish ethnography and art in works by Betty Olivero and Joseph Bardanashvili: Olivero undoes exoticisms by multiplying variants, temporalities, and harmonic additives that together deem the movement from one variant to another more meaningful than any potential (and in fact nonexistent) ethnographic “source.” Bardanashvili, comparatively, employs mutable Hebrew psalmodic formulae and polystylistic solvents whose most constituent feature is porousness. Two novels by A. B. Yehoshua steer this chapter—the 1999 Journey to the End of the Millennium (the title of Bardanashvili’s 2005 opera), and The Tunnel (2018), which recounts the atrophy of memory in contemporary Israel. Atrophy in turn is examined in the late works of Olivero and Czernowin.
Allodynia (skin tenderness) associated with semaglutide: A case series
Authors: Stark Jennifer , Klass Marian J , Owen Lauren 
Published: January 2025

Abstract

Purpose
The glucagon-like peptide-1 receptor agonist (GLP-1RA) class of medications are widely prescribed for management of diabetes mellitus as well as obesity or weight management. Although there have been rare reports of skin hypersensitivity associated with GLP-1RA medications, no published reports have documented allodynia or skin pain to the touch.

Summary
We report 4 cases of allodynia associated with dose escalation of the GLP-1RA medication semaglutide. Each patient was prescribed semaglutide for management of obesity and developed symptoms of allodynia with the 2.4-mg subcutaneous once-weekly dose. Therapy was stopped in 2 patients, both of whom had resolution of symptoms. Two patients opted to continue semaglutide despite the adverse effect, with one experiencing resolution after 4 months. No pharmacological mechanism was identified for this unique adverse drug reaction. There was a clear temporal and dose-response relationship in each of the 4 cases.

Conclusion
The 4 cases presented had scores of 5 or 6 (probable) on the Naranjo scale. It is not known whether this is a class effect of the GLP-1RA medications or if the adverse effect will consistently resolve or improve with continuation.
A preliminary study of microwave ablation for Bethesda IV follicular neoplasms (≤3 cm)
Authors: Yu Xin-Yu , Zhou Xin-yi , Wei Ying , Zhao Zhen-Long , Peng Li-Li , Li Yan , Wu Jie , Cao Shi-Liang , Yu Ming-an 
Published: January 2025

Abstract

Objectives
To evaluate the feasibility, safety, and efficacy of microwave ablation (MWA) for the treatment of patients with Bethesda IV follicular neoplasms (FNs) (≤3 cm).

Methods
In the retrospective study, patients who underwent MWA for Bethesda IV FNs (≤3 cm) were included. Technical success, volume reduction, disease progression, and adverse event (AE) rates were analysed postablation.

Results
The study cohort consisted of 44 patients with a mean age of 48.2 ± 15.7 years. The median follow-up period was 16 months (interquartile range [IQR]: 9-24 months). The technical success rate was 100%. The median volume reduction ratio (VRR) reached 100% (IQR: 98.8%-100.0%) after the 18th month of follow-up. The disease progression rate was 4.5% (2/44), and both of those patients experienced local recurrence. The overall AE rate was 9.1% (4/44), and AEs included 3 cases of voice hoarseness and 1 case of cough.

Conclusion
This study presents promising clinical outcomes regarding the feasibility, efficacy, and safety of MWA for the treatment of patients with Bethesda IV FNs ≤ 3 cm.

Advances in knowledge
The study highlights the high technical success rate, low disease progression rate and AE rate of MWA for FNs, which underscores its potential for broader application. Future research should aim to validate these results in larger populations to increase the scope of therapy for FNs.
Learning to optimize based on rate decay
Authors: Ma Wenmin 
Published: January 2025

Abstract
Learning to optimize (L2O) is a technique that uses neural networks to learn optimization algorithms automatically. While it holds promise for diverse optimization problems, achieving consistently ideal results remains a challenge. Typically, L2O through a parameterized optimization method (i.e. “ optimizer”) learns from training samples and generalizes to test tasks with the same distribution. However, the new test tasks usually have some deviation from the training set distribution. In this case, the generic L2O methods may not produce good optimization results. Thus, we introduce a step-size control mechanism based on the generic L2O to solve the common problem of insufficient control of the iteration amplitude in L2O and adopt different update strategies for various optimization problems to adapt to complex optimization scenarios. Additionally, we also innovatively use the gated recurrent unit network as the core model of the optimizer to achieve better optimization results. Finally, the experimental outcomes from numerical simulations and real-world datasets show that our proposed methods are significantly better than other optimization algorithms.
Understanding the Lived Experience After Colectomy and Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: A Qualitative Study
Authors: Barnes Edward L , Boynton Marcella H , DeWalt Darren A , Brenner Erica , Herfarth Hans H , Kappelman Michael D 
Published: January 2025

Abstract

Background
The patient experience after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) remains poorly defined, resulting in heterogeneity in clinical assessments and research. We performed a qualitative study to better understand the experience of patients after IPAA for UC, with a focus on the symptoms experienced by patients and the resultant effects on quality of life (QoL).

Methods
We conducted semi-structured focus groups among patients who had undergone IPAA for UC. We invited patients with a variety of pouch-related conditions, including patients reporting normal pouch function and those with diagnosed inflammatory conditions of the pouch. We included questions on patients’ experiences and symptoms after IPAA based on 4 thematic areas identified by a previously performed systematic review: bowel symptoms, activities, general issues and quality of life, and psychosocial.

Results
We interviewed 15 individuals over the course of 4 focus groups. Participants described the significant impact that bowel symptoms after IPAA had on other activities including work and daily life, and their subsequent relation to QoL themes. Participants noted symptoms of frequency, urgency, and incontinence after IPAA, and many shared how these symptoms required them to change their lifestyle, particularly by altering their daily schedule or changing their diet. Nevertheless, most participants reported QoL improvement after IPAA.

Conclusions
In this qualitative study evaluating the experience of patients after IPAA, multiple bowel-related symptoms impact other areas of life and overall QoL. Patients undergoing IPAA for UC represent a unique patient population, and thus patient-centered outcome measures should be designed to standardize their assessment.
Lipid-Lowering and Antihypertensive Drugs on Aortic Disease Risk: Insights from Mendelian Randomization Analysis and Real-World Pharmacovigilance Data
Authors: Han Nie , Zhao Wenpeng , Wang Qingqing , Zhou Weimin 
Published: January 2025

Abstract

Objective
To assess the impact of lipid-lowering drugs (LLDs) and antihypertensive drugs on the risk of aortic diseases.

Methods
Mendelian randomization was utilized to analyze data from 500,000 participants in the UK Biobank to evaluate the effects of statins, PCSK9 inhibitors (PCSK9i), beta-blockers, and calcium channel blockers on the risks of thoracic aortic aneurysm (TAA), abdominal aortic aneurysm (AAA), and aortic dissection (AD) using genetic variants as proxies. Real-world pharmacovigilance data from the FAERS database was used.

Results
PCSK9i and statins significantly reduced the risks of aortic aneurysms and AD, respectively. Furthermore, the two LLDs reduced the risk of aortic diseases through certain metabolites. Meanwhile, real-world pharmacovigilance reports also indicated a low incidence of aortic diseases with PCSK9i and statin treatment.

Conclusion
LLDs, particularly statins and PCSK9i, significantly protect against aortic diseases, providing a scientific basis for preventing and treating aortic diseases.
The optimal annual case volume for acute type A aortic dissection surgery in relation to long-term outcomes
Authors: Kawczynski Michal J , van Kuijk Sander M J , Olsthoorn Jules R , Maessen Jos G , Kats Suzanne , Bidar Elham , Heuts Samuel 
Published: January 2025

Abstract

OBJECTIVES
Previous analyses of the volume–outcome relationship have focused on short-term outcomes such as early mortality. The current study aims to update a novel statistical methodology, facilitating the evaluation of the relation between procedural volume and time-to-event outcomes such as long-term survival, using surgery for acute type A aortic dissection as an illustrative example.

METHODS
This study employed an existing dataset of type A dissection outcomes, retrieved from literature. Studies were included when reporting on annual case load and long-term survival, which served as the primary outcome of interest. Individual patient data were reconstructed from the included studies, and a hazard ratio was determined per study in relation to overall survival, after which the calculated hazard ratios were incorporated in a restricted cubic-spline model, facilitating the application of the elbow method.

RESULTS
Fifty-two studies were included (n = 14 878 patients), with a median follow-up of 5 years. One-, 3-, 5- and 10-year survival of the overall cohort were 82% [95% confidence interval (CI) 82–83%], 79% (95% CI 78–80%), 74% (95% CI 74–75%) and 60% (95% CI 59–62%), respectively. A significant non-linear volume–outcome relation for long-term survival was observed in both the unadjusted and adjusted analyses (P = 0.030 and P = 0.002), with an optimal annual case load of 32 cases/year (95% CI 31–33).

CONCLUSIONS
Based on the available data, these findings imply that the annual case volume to achieve optimal long-term survival is located near a procedural volume of 32 cases/year. After accrual of more annual procedures, long-term survival may no longer significantly improve any further.