bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated semi‐quantum layered communication
Authors: Bala Rajni , Asthana Sooryansh , Ravishankar V. 
Published: November 2023

AbstractIn recent times, secure quantum communication in layered networks has emerged as an important area of study. The authors harness the potential offered by multidimensional states in secure quantum communication with only one quantum participant and all the other classical participants. Three protocols are proposed for—(i) entanglement‐based layered semi‐quantum key distribution, (ii) layered semi‐quantum secret sharing, and (iii) integrated layered semi‐quantum key distribution and secret sharing to share secret information in arbitrarily layered networks. These protocols integrate the features of semi‐quantum communication in layered networks. All three protocols allow for simultaneous distribution of secure information in all the layers of a network, thanks to the employment of multidimensional states. These protocols are presented for a small network of at most five participants and three layers and show the robustness of the same against various eavesdropping strategies. Finally, a detailed procedure is provided for generalisations of the proposed protocols to distribute keys/secrets in any arbitrarily structured quantum network.
The XXL Survey
Authors: Adam R. , Ricci M. , Eckert D. , Ade P. , Ajeddig H. , Altieri B. , André P. , Artis E. , Aussel H. , Beelen A. , Benoist C. , Benoît A. , Berta S. , Bing L. , Birkinshaw M. , Bourrion O. , Boutigny D. , Bremer M. , Calvo M. , Cappi A. , Catalano A. , De Petris M. , Désert F.-X. , Doyle S. , Driessen E. F. C. , Faccioli L. , Ferrari C. , Gastaldello F. , Giles P. , Gomez A. , Goupy J. , Hahn O. , Hanser C. , Horellou C. , Kéruzoré F. , Koulouridis E. , Kramer C. , Ladjelate B. , Lagache G. , Leclercq S. , Lestrade J.-F. , Macías-Pérez J. F. , Madden S. , Maughan B. , Maurogordato S. , Maury A. , Mauskopf P. , Monfardini A. , Muñoz-Echeverría M. , Pacaud F. , Perotto L. , Pierre M. , Pisano G. , Pompei E. , Ponthieu N. , Revéret V. , Rigby A. , Ritacco A. , Romero C. , Roussel H. , Ruppin F. , Sereno M. , Schuster K. , Sievers A. , Tintoré Vidal G. , Tucker C. , Zylka R. 
Published: November 2023

Context. The thermodynamical properties of the intracluster medium (ICM) are driven by scale-free gravitational collapse, but they also reflect the rich astrophysical processes at play in galaxy clusters. At low masses (∼1014 M⊙) and high redshift (z ≳ 1), these properties remain poorly constrained, observationally speaking, due to the difficulty in obtaining resolved and sensitive data.
Aims. We aim to investigate the inner structure of the ICM as seen through the Sunyaev–Zel’dovich (SZ) effect in this regime of mass and redshift. We focused on the thermal pressure profile and the scaling relation between SZ flux and mass, namely the YSZ − M scaling relation.
Methods. The three galaxy clusters XLSSC 072 (z = 1.002), XLSSC 100 (z = 0.915), and XLSSC 102 (z = 0.969), with M500 ∼ 2 × 1014 M⊙, were selected from the XXL X-ray survey and observed with the NIKA2 millimeter camera to image their SZ signal. XMM-Newton X-ray data were used as a complement to the NIKA2 data to derive masses based on the YX − M relation and the hydrostatic equilibrium.
Results. The SZ images of the three clusters, along with the X-ray and optical data, indicate dynamical activity related to merging events. The pressure profile is consistent with that expected for morphologically disturbed systems, with a relatively flat core and a shallow outer slope. Despite significant disturbances in the ICM, the three high-redshift low-mass clusters follow the YSZ − M relation expected from standard evolution remarkably well.
Conclusions. These results indicate that the dominant physics that drives cluster evolution is already in place by z ∼ 1, at least for systems with masses above M500 ∼ 1014 M⊙.
Chemotherapie nach Progress unter Immuncheckpoint-Inhibition beim metastasierten malignen Melanom: Fallbericht und Literaturübersicht
Authors: Weilandt Juliane , Lebahn Herbert , Ludwig-Peitsch Wiebke 
Published: November 2023

Zusammenfassung
Hintergrund Immuncheckpoint-Inhibitoren (ICI), BRAF- und MEK-Inhibitoren haben die Prognose von Patienten mit metastasiertem malignem Melanom entscheidend verbessert. Nichtsdestotrotz spricht ein erheblicher Prozentsatz nicht oder nur vorübergehend auf diese modernen Therapien an. Insbesondere bei Patienten mit BRAF-Wildtyp-Melanom sind die Therapieoptionen nach Versagen von ICI limitiert.
Kasuistik Eine 24-jährige Patientin stellte sich im Dezember 2015 mit einem akrolentiginösen malignen Melanom am linken Fußballen im Tumorstadium IIB (pT4a, pN0, cM0, Infiltrationstiefe 7,95 mm, BRAF-V600-Wildtyp) vor, das leitliniengerecht operativ versorgt und für 18 Monate adjuvant mit Interferon-alpha behandelt wurde. Nach Diagnose von zwei Lymphknotenmetastasen links inguinal und radikaler Lymphknotendissektion erhielt die Patientin für 12 Monate eine adjuvante Therapie mit Nivolumab. Nach einem 10-monatigen tumorfreien Intervall ohne Therapie erbrachte das Staging eine paraaortale Lymphknotenmetastase. Gemäß Tumorkonferenz-Beschluss wurde bei nunmehr vorliegendem Stadium IV eine Immunkombinationstherapie mit Nivolumab und Ipilimumab begonnen, die nach 2 Gaben aufgrund einer Autoimmunkolitis und -hepatitis Grad 3 beendet und auf eine Nivolumab-Monotherapie umgestellt wurde. Bei erneutem Tumorprogress auch nach Metastasenresektion und fehlender Möglichkeit einer Studienteilnahme wurde eine palliative Chemotherapie mit Dacarbazin 850 mg/m2 alle 3 Wochen eingeleitet. Hiermit ließ sich nach 4 Zyklen eine partielle Remission und nach 10 Zyklen eine Komplettremission erzielen, die nunmehr seit 10 Monaten ohne Therapie anhält.
Diskussion Es gibt Hinweise darauf, dass die Effektivität einer Chemotherapie nach vorangegangener Immuncheckpoint-Inhibition höher ist als ohne diese Vortherapie, möglicherweise durch einen immunmodulatorischen Effekt der Chemotherapie, der synergistisch mit einer Immunaktivierung durch ICI wirkt. Bisher liegen nur wenige Studien zu dieser Therapiesequenz beim Melanom vor, bei denen es sich ausschließlich um retrospektive Analysen handelt. Diese weisen auf einen klinischen Nutzen der Therapiesequenz hin, wenngleich die Evidenz hierfür sehr gering ist. Die meisten Patienten, die nach einer Vortherapie mit ICI auf Dacarbazin oder andere Chemotherapien ansprechen, erreichen eine partielle Remission. Anhaltende Komplettremissionen wie bei unserer Patientin sind eine Rarität.
Clinical Applications of Radiomics in Nuclear Medicine
Authors: Lohmann Philipp , Bundschuh Ralph Alexander , Miederer Isabelle , Mottaghy Felix M. , Langen Karl Josef , Galldiks Norbert 
Published: November 2023

AbstractRadiomics is an emerging field of artificial intelligence that focuses on the extraction and analysis of quantitative features such as intensity, shape, texture and spatial relationships from medical images. These features, often imperceptible to the human eye, can reveal complex patterns and biological insights. They can also be combined with clinical data to create predictive models using machine learning to improve disease characterization in nuclear medicine. This review article examines the current state of radiomics in nuclear medicine and shows its potential to improve patient care. Selected clinical applications for diseases such as cancer, neurodegenerative diseases, cardiovascular problems and thyroid diseases are examined. The article concludes with a brief classification in terms of future perspectives and strategies for linking research findings to clinical practice.
Aesthetic Evaluation and Validation: Umbilicus Reconstruction after DIEP Flap
Authors: Haddock Nicholas T. , Steppe Cyrus , Teotia Sumeet S. 
Published: November 2023

Abstract
Background The most common method for autologous breast reconstruction is the deep inferior epigastric perforator (DIEP) flap. The umbilicus can be managed in various ways, including re-inset, neoumbilicus, and umbilectomy without reconstruction. This study evaluated the aesthetic differences in umbilicus reconstruction choice and variation in patients' postoperative satisfaction with their abdomen.
Methods A retrospective review of 1,019 patients treated with DIEP flap breast reconstruction between August 2009 and January 2022 was conducted. Patients were stratified by management of the umbilicus: preservation and re-inset of the native umbilicus, umbilectomy with delayed reconstruction, and umbilectomy with no reconstruction. A crowdsourced survey was created to assess the aesthetic preference of each photograph using a Likert scale.
Results There were 1,063 responses to the umbilicus preference crowd source survey. Patients who had delayed umbilicus reconstruction after umbilectomy were rated to be significantly more attractive (4.397 ± 1.697) than both preservation of the native umbilicus (4.176 ± 1.669) and lack of the umbilicus (3.994 ± 1.733; p < 0.001 and <0.001, respectively). In an analysis of the BREAST-Q scores, delayed reconstruction patients had a similar change across measures when compared to the re-inset group. The delayed group had a significantly higher change in overall satisfaction and well-being with abdomen when compared with the no reconstruction group (p = 0.006 and 0.027, respectively).
Conclusion This study demonstrates that umbilectomy with delayed reconstruction yields a significantly higher aesthetic rating and comparable patient satisfaction when compared to re-inset of the umbilicus.
Propofol versus Desflurane in Moyamoya Disease Patients—A Pilot Study
Authors: Ankolekar Ronak R. , Kaur Kirandeep , Jangra Kiran , Aggarwal Ashish , Panda Nidhi B. , Bhagat Hemant , Barik Amiya K. 
Published: November 2023

Abstract
Objectives The choice of inhalational or intravenous anesthetic agents is debatable in neurosurgical patients. Desflurane, a cerebral vasodilator, may be advantageous in ischemic cerebral pathologies. Hence, we planned to compare desflurane and propofol in patients with moyamoya disease (MMD) with the objective of comparing neurological outcomes.
Materials and Methods This prospective pilot trial was initiated after institutional ethics committee approval. Patients with MMD undergoing revascularization surgery were randomized into two groups receiving either desflurane or propofol intraoperatively. Neurological outcomes were assessed using a modified Rankin score (mRS) at discharge and an extended Glasgow outcome score (GOS-E) at 1 month. Intraoperative parameters, including hemodynamic parameters, end-tidal carbon dioxide, entropy, intraoperative brain relaxation scores (BRS), and rescue measures for brain relaxation, were compared.
Statistical Analysis The normality of quantitative data was checked using Kolmogorov–Smirnov tests of normality. Normally distributed data were compared using unpaired t-tests, skewed data using Mann–Whitney U tests, and categorical variables using chi-squared tests.
Results A total of 17 patients were randomized, 10 in the desflurane and 7 in the propofol group. mRS (1.3 ± 0.6 and 1.14 ± 0.4, p = 0.450) and GOS-E (6.7 ± 0.6 and 6.85 ± 0.5, p = 0.45) were comparable between desflurane and propofol groups, respectively. BRS was significantly higher in the desflurane group (3.6 ± 0.5) compared to the propofol group (2.1 ± 0.3, p = 0.001), with a significant number of patients requiring rescue measures in the desflurane group (70%, p < 0.001). Other outcome parameters were comparable (p > 0.05).
Conclusion We conclude that postoperative neurological outcomes were comparable with using either an anesthetic agent, desflurane, or propofol in MMD patients undergoing revascularization surgery. Maintenance of anesthesia with propofol had significantly superior surgical field conditions.
Artificial intelligence-driven scalability and its impact on the sustainability and valuation of traditional firms
Authors: Moro-Visconti Roberto , Cruz Rambaud Salvador , López Pascual Joaquín 
Published: November 2023

AbstractThe objective of this study is to determine the impact of artificial intelligence (AI) on the earnings before interest, taxes, depreciation, and amortization (EBITDA) of firms as a proxy of their financial and economic margins by improving revenues and minimizing expenses. This impact is positive on the market value and scalability by improving the economic and financial sustainability of companies. The methodology is based on a business plan that considers the savings obtained by a traditional firm implementing AI. Specifically, a sensitivity analysis will demonstrate that AI savings impact key parameters, leading to economic and financial sustainability. Additionally, a mathematical interpretation, based on network theory, will be produced to provide and compare the added value of two ecosystems (without and with AI that adds up new nodes and strengthens the existing ones). The main contribution of this paper is the combination of two unrelated approaches, showing the potential of AI in scalable ecosystems. In future research, this innovative methodology could be extended to other technological applications.
Multimode optomechanics with a two-dimensional optomechanical crystal
Authors: Madiot Guilhem , Albrechtsen Marcus , Stobbe Søren , Sotomayor-Torres Clivia M. , Arregui Guillermo 
Published: November 2023

Chip-scale multimode optomechanical systems have unique benefits for sensing, metrology, and quantum technologies relative to their single-mode counterparts. Slot-mode optomechanical crystals enable sideband resolution and large optomechanical couplings of a single optical cavity to two microwave-frequency mechanical modes. Still, previous implementations have been limited to nanobeam geometries, whose effective quantum cooperativity at ultralow temperatures is limited by their low thermal conductance. In this work, we design and experimentally demonstrate a two-dimensional mechanical–optical–mechanical (MOM) platform that dispersively couples a slow-light slot-guided photonic-crystal waveguide mode and two slow-sound ∼ 7 GHz phononic wire modes localized in physically distinct regions. We first demonstrate optomechanical interactions in long waveguide sections, unveiling acoustic group velocities below 800 m/s, and then move on to mode-gap adiabatic heterostructure cavities with a tailored mechanical frequency difference. Through optomechanical spectroscopy, we demonstrate optical quality factors Q ∼ 105, vacuum optomechanical coupling rates, go/2π, of 1.5 MHz, and dynamical back-action effects beyond the single-mode picture. At a larger power and adequate laser-cavity detuning, we demonstrate regenerative optomechanical oscillations involving a single mechanical mode, extending to both mechanical modes through modulation of the input laser drive at their frequency difference. This work constitutes an important advance toward engineering MOM systems with nearly degenerate mechanical modes as part of hybrid multipartite quantum systems.
Electromagnetically induced transparency in a strongly coupled orthogonal polarization-insensitive planar terahertz metamaterial
Authors: Vaswani Lavi Kumar , Chouhan Bhagwat Singh , Panwar Anuraj , Kumar Gagan 
Published: November 2023

Abstract
We demonstrate experimentally and numerically the electromagnetically induced transparency (EIT) effect in a strongly coupled planar terahertz (THz) metamaterial. The circular-shaped four-arc geometry combined with cross resonators ensures the polarization-insensitive response of the EIT for the orthogonal polarization incident THz. The EIT response can be varied by changing the gap between the arc and cross-shaped resonators. The field profiles indicate a strong coupling between the resonators leading to the EIT effect. In order to understand the underlying physical mechanism, we employed a coupled harmonic oscillator model, which suggests an increase in coupling when the distance between resonators is reduced. THz time-domain spectroscopy of the fabricated samples with the same shape and size of the simulated structures was used to verify the numerical findings. Our study uses a symmetric and easy-to-fabricate planar metasurface that can pave the way for the design and construction of THz photonic components, such as optical switches and slow light devices.
The third post-Newtonian equatorial motion in Kerr spacetime
Authors: Yang Bo , Lin Wenbin 
Published: November 2023

Abstract
We calculate the third post-Newtonian (PN) order solution for the equatorial motion of a test particle in Kerr spacetime. In particular, we obtain the effects of the spin-induced quadrupole on the periastron advance and the orbital period at the 3PN order.
Mimetic inflation and self-reproduction
Authors: Chamseddine A.H. , Khaldieh M. , Mukhanov V. 
Published: November 2023

Abstract
It is shown how self-reproduction can be easily avoided in the inflationary universe, even
when inflation starts at Planck scales. This is achieved by a simple coupling of the inflaton
potential with a mimetic field. In this case, the problem of fine-tuning of the initial conditions
does not arise, while eternal inflation and the multiverse with all their widely discussed
problems are avoided.
Cold New Early Dark Energy pulls the trigger on the H
0 and S
8 tensions: a simultaneous solution to both tensions without new ingredients
Authors: Cruz Juan S. , Niedermann Florian , Sloth Martin S. 
Published: November 2023

Abstract
In this work, we show that the Cold New Early Dark Energy (Cold NEDE) model in its
original form can solve both the Hubble tension and the S
8 tension without adding any new
ingredients at the fundamental level. So far, it was assumed that the trigger field in the Cold
NEDE model is completely subdominant. However, relaxing this assumption and letting the trigger
field contribute a mere 0.5% of the total energy density leads to a resolution of the S
8
tension while simultaneously improving it as a solution to the H
0 tension. Fitting this model
to baryonic acoustic oscillations, large-scale-structure, supernovae (including a SH0ES prior),
and cosmic microwave background data, we report a preferred NEDE fraction of f
NEDE =
0.134+0.032
-0.025 (68% C.L.), lifting its Gaussian evidence for the first time above
5σ (up from 4σ when the trigger contribution to dark matter is negligible). At the
same time, we find the new concordance values H
0 = 71.71 ± 0.88 km sec-1 Mpc-1 and S
8 = 0.793 ± 0.018. Excluding large-scale
structure data and the SH0ES prior, both Gaussian tensions are reduced below the 2σ
level.
Influence of local structure on relic neutrino abundances and anisotropies
Authors: Zimmer Fabian , Correa Camila A. , Ando Shin'ichiro 
Published: November 2023

AbstractGravitational potentials of the Milky Way and extragalactic structures can influence the propagation of the cosmic neutrino background (CNB). Of particular interest to future CNB observatories, such as PTOLEMY, is the CNB number density on Earth. In this study, we have developed a simulation framework that maps the trajectories of relic neutrinos as they move through the local gravitational environment. The potentials are based on the dark matter halos found in state-of-the-art cosmological N-body simulations, resulting in a more nuanced and realistic input than the previously employed analytical models. We find that the complex dark matter distributions, along with their dynamic evolution, influence the abundance and anisotropies of the CNB in ways unaccounted for by earlier analytical methods. Importantly, these cosmological simulations contain multiple instances of Milky Way-like halos that we employ to model a variety of gravitational landscapes. Consequently, we notice a variation in the CNB number densities that can be primarily attributed to the differences in the masses of these individual halos. For neutrino masses between 0.01 and 0.3 eV, we note clustering factors within the range of 1 + 𝒪(10-3) to 1 + 𝒪(1). Furthermore, the asymmetric nature of the underlying dark matter distributions within the halos results in not only overdense, but intriguingly, underdense regions within the full-sky anisotropy maps. Gravitational clustering appears to have a significant impact on the angular power spectra of these maps, leading to orders of magnitude more power on smaller scales beyond multipoles of ℓ = 3 when juxtaposed against predictions by primordial fluctuations. We discuss how our results reshape our understanding of relic neutrino clustering and how this might affect observability of future CNB observatories such as PTOLEMY.GitHub: our simulation code will be made visiblehere.
Outcomes and use of healthcare resources after an intervention for chronic limb-threatening ischaemia
Authors: Saratzis Athanasios , Musto Liam , Kumar Santosh , Wang Jingyi , Bojko Louis , Lillington Joseph , Anyadi Patrick , Zayed Hany 
Published: November 2023

Abstract

Background
The fate of patients with chronic limb-threatening ischaemia undergoing revascularization or a primary amputation is unclear. The aim of this study was to assess the postoperative outcomes and post-procedural healthcare resource use/costs over 1 year after revascularization or a primary amputation for chronic limb-threatening ischaemia.

Methods
The UK Kent Integrated Dataset, which links primary, community, and secondary care for 1.6 million people, was interrogated. All patients with a new diagnosis of chronic limb-threatening ischaemia undergoing revascularization or a major amputation between January 2016 and January 2019 (3 years) were identified. Postoperative events across all healthcare settings and post-procedure healthcare resource use were analysed over 1 year (until the end of 2019).

Results
Overall, 4252 patients with a new diagnosis of chronic limb-threatening ischaemia were identified (65 per cent were male and the mean age was 73 years) between January 2016 and January 2019, of whom 579 (14 per cent) underwent an intervention (studied population); 296 (7 per cent) had an angioplasty, 75 (2 per cent) had bypass surgery, 141 (3 per cent) had a primary major lower limb amputation, 11 had a thrombo-embolectomy (0.3 per cent), and 56 had an endarterectomy (1.3 per cent). Readmissions (median of 2) were similar amongst different procedures within 1 year; bypass surgery was associated with more hospital appointments (median of 4 versus 2; P = 0.002). Patients undergoing a primary amputation had the highest number of cardiovascular events and 1-year mortality. In a linear regression model, index procedure type and Charlson co-morbidity index score were not predictors of appointments in primary/secondary care, community care visits, or readmissions after discharge. There were no statistically significant differences regarding post-procedural healthcare costs between procedures over 1 year.

Conclusion
Revascularization is not associated with more hospital, primary/community care appointments or increased post-procedural healthcare costs over 1 year when compared with primary amputation, in people with chronic limb-threatening ischaemia.