bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Education and Training (Diklat), Competency on Position Promotion and Employee Performance of Eco Beach Villa and Apartment Canggu
Authors: Wibisono Gunawan , Nugraha Surya 
Published: January 2024

This research aims to analyze the influence of education and training (Diklat), competency on position promotion and employee performance at Eco Beach Villa and Canggu Apartments in companies in the tourism industry sector in Badung district. In this study, the population studied was 216 permanent employees at Eco Beach Villa and Apartment Canggu. This research sample used the Solvin formula to obtain 68 people. The analysis technique used is "path analysis". The analysis results show that: 1). Education and training have a positive and significant effect on the work performance of Eco Beach Villa and Apartment Canggu employees; 2). Competence has a positive and significant effect on the performance of Eco Beach Villa and Apartment Canggu employees; 3). Education and training have a direct influence on the promotion of Eco Beach Villa and Apartment Canggu employees; 4). Competency has a direct influence on the promotion of Eco Beach Villa and Apartment Canggu employees; 5). Job promotions have a direct effect on the performance of Eco Beach Villa and Apartment Canggu employees; 6). Education and training have a significant indirect effect on the performance of Eco Beach Villa and Apartment Canggu employees through job promotions; 7). Competency has a significant indirect effect on the performance of Eco Beach Villa and Apartment Canggu employees through job promotions.
Keywords: Education and Training, Competency, Position Promotion, Employee Performance.
An Analysis of Room Reservation Practice Learning Obstacle for Students in The Second Diploma of Accommodation at The Community Academy of MAPINDO
Authors: Agustina Riski Gusti Ayu 
Published: January 2024

Room Reservation practice is one of the courses that aims to prepare students so that they have the competenceto handle room requests, process bookings, and archive the history of room bookings. Learning in the practiceof booking rooms uses the role play method, where students act as reservation agents and others as guestswith the material being Room Reservation procedures via telephone operator. However, in the learningprocess, there are several obstacles in learning that hinder the achievement of the objectives of the learningoutcomes. The purpose of this research is to analyze the types of difficulties experienced by students along withthe factors that cause them as well as the efforts made by students to overcome these obstacles so that learningabout the practice of booking rooms can run in accordance with the stated objectives. The research methodused is a qualitative method, collecting data through observation, distributing questionnaires, interviews anddocumentation. Respondents in this study were 29 students, selected purposively (purposive sampling),namely students who had experiences in practical learning process for booking rooms. Analysis techniques usequalitative data. The research results show that students have difficulty recording guest payment methods,allocating rooms, providing room rates, and filling in reservation charts. The causal factors are divided intointernal factor (such us: lack pf confidence, and language barriers) and external factor (lak of facilities and timeallocating). The efforts made by students are to study again and practice a lot of role plays, as well as lookingfor references from other sources.Keywords: Barriers, Learning, Front Office Practice, Front Office Practice
Identify Industrial Work Practices in the Food and Beverage Product Department of Kayumas Seminyak Resort
Authors: Antara I Made Kusuma , Anggayana I Wayan Agus , Dwiyanti Ni Made Christine , Sengkey Fenny 
Published: January 2024

This research Identify Industrial Work Practices in the Food and Beverage Product Department of Kayumas Seminyak Resort. It can be used as a guide to improve the quality of work and creativity in entering the tourism industry. Increasing student knowledge in the Food and Beverage products field and implementing training will be helpful later when facing the industrial world. This research is descriptive qualitative research. The document used in this research is taken from Industrial Work Practices in the Food and Beverage Product Department of Kayumas Seminyak Resort Students' report. After carrying out industrial work practices, the researcher gained a lot of useful work experience in the form of theories and practical knowledge regarding the Food and Beverage Product field and the ability to work together. In addition, the author has carried out one of the requirements for completing the Food and Beverage Product Study program by carrying out industrial work practices.
Keywords: Industrial Work Practices, Food and Beverage Product Department, Quality of work, Tourism Industry, Kayumas Seminyak Resort.
Identify Industrial Work Practices in the Food and Beverage Product Department of Quest Hotel Kuta
Authors: Ditya Adi Putra I Made Marianto , Anggayana I Wayan Agus 
Published: January 2024

This research identifies industrial Work Practices in the Food and Beverage Product Department of Quest Hotel Kuta. It can be used as a guide to improve the quality of work and creativity in entering the tourism industry. Increasing student knowledge in the Food and Beverage products field and implementing training will be helpful later when facing the industrial world. This research is descriptive qualitative research. The document used in this research is taken from Industrial Work Practices in the Food and Beverage Product Department of Quest Hotel Kuta Students' report. After carrying out industrial work practices, the researcher gained a lot of useful work experience in the form of theories and practical knowledge regarding the Food and Beverage Product field and the ability to work together. In addition, the author has carried out one of the requirements for completing the Food and Beverage Product Study program by carrying out industrial work practices.
Keywords: Industrial Work Practices, Food and Beverage Products, Tourism Industry, Quest Hotel Kuta.
A new study on diffusion tensor imaging of the whole visual pathway fiber bundle and clinical application
Authors: TAO Xiao-feng , WANG Zhong-qiu , GONG Wan-qing , JIANG Qing-jun , SHI Zeng-ru 
Published: January 2024

Background
With conventional imaging methods only the morphous of the visual nerve fiber bundles can be demonstrated, while the earlier period functional changes can not be demonstrated. We hypothesized that diffusion tensor imaging (DTI) would demonstrated the whole optic never fiber bundle and visual pathway and the earlier period functional changes. The purpose of the present study was to evaluate the application of DTI technique in the demonstration of the whole optic never fiber bundle and visual pathway, and the influence of orbital tumors on them.

Methods
GE 1.5T signa HD MR System, and the software package DTV2 were adopted. The total 45 subjects were enrolled, including 15 volunteers and 30 patients. All patients had ocular proptosis from minor to major. Seven patients had visual acuity decrescence.

Results
The nerve fiber bundles, e.g. optic chiasma, optic tract and optic radiation in posterior visual pathway were well demonstrated in all cases. Wherein, the intact whole visual pathway fiber bundles were clearly revealed in 10 volunteers and 17 patients, and optic nerve was not wholly revealed in the rest of the subjects. Shift of optic nerve caused by compression and partial deformation were seen in 7 patients with orbital tumor. In 6 of 7 patients, DTI displayed significant abscise and deformation of visual nerve. Chi-square test indicated significant correlation between visual acuity decrescence and DTI visual nerve non-display.

Conclusions
Visual nerve fiber bundles and the whole visual pathway were visualized in most of patients with DTI. It might be an effective method of providing imaging evidence for visual nerve fiber earlier period functional changes, and laid a foundation for the study in other cranial nerves.
Blood purification therapy in treatment of acute renal failure in infants with melamine-induced stones
Authors: SHEN Ying , LIU Xiao-rong , ZHANG Gui-ju , ZHOU Nan 
Published: January 2024

Background
In 2008, infants in some areas of China suffered from stones of the urinary system which were caused by melamine-contaminated milk formula. Most of the infants were asymptomatic, and a few suffered from acute renal failure induced by urinary obstruction by stones. This study aimed to assess the significance of blood purification therapy in treatment of infants with acute obstructive oligo-anuric renal failure. Corrective perception, timely diagnosis, and active treatment of this complex disease are critical factors that guarantee a quick recovery of renal function of infants and help them to prevent multiple organ system failure.

Methods
Thirteen infants with acute renal failure induced by urinary multiple obstruction caused by melamine-containing stones who had been admitted to Beijing Children's Hospital Affiliated to Capital Medical University in 2008 were investigated for the epidemiological characteristics, image features and indications of dialysis. All these infants were treated with dialysis. The efficacy of dialysis was compared with that of two control groups treated with cystoscopic retrograde catheterization into the ureter and medical treatment for the recovery of renal function.

Results
The 13 infants with life-threatening complications treated with dialysis showed a blood urea nitrogen (BUN) level of (30.9±7.9) mmol/L and a creatinine (Cr) level of (572±173) μmol/L. Of these infants, 8 were treated with peritoneal dialysis (PD), and 5 with hemodialysis (HD). Ten infants recovered to urinate 24–72 hours after dialysis and 3 infants with persistent ureteral obstruction were further treated with cystoscopic retrograde catheterization into the ureter for drainage, and urination resumed soon after the operation. The average time of PD and HD were (2.1±0.8) days and (1.2±0.4) days, respectively. The total average time of PD and HD dialysis was (1.77±0.83) days. The recovery time of renal function of infants after dialysis was (3.08±1.20) days, comparable to that of the two control groups treated with catheterization with a cystoscope or by medication. There was no significant difference in the recovery time of renal function among the three groups (P>0.05).

Conclusions
Melamine-contaminated milk formula may cause urinary stones and obstructive acute renal failure in infants. Dialysis is suggested to treat life-threatening complications such as hyperkalemia, oliguria or anuria if surgical intervention fails. If possible, hemodialysis or peritoneal dialysis can be performed early. Blood purification is feasible to help the infants overcome the critical stage of acute renal failure. Surgical measures can be taken to remove the obstruction if necessary.
Mutation of plakophilin-2 gene in arrhythmogenic right ventricular cardiomyopathy
Authors: WU Shu-lin , WANG Pei-ning , HOU Yue-shuang , ZHANG Xu-chao , SHAN Zhi-xin , YU Xi-yong , DENG Mei 
Published: January 2024

Background
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is one of the leading causes of sudden cardiac death. Recent studies have shown that ARVC, which is an inheritable genetic change, results from mutations in genes encoding desmosomal proteins. Plakophilin-2 is an important component of the desmosome. Because the full range of genetic variations related to ARVC is unknown and no related studies of the Chinese population have been reported, we aimed to investigate the genetic variation of plakophilin-2 in ARVC patients from the Southern Region of China.

Methods
Genomic DNA was isolated from peripheral blood samples of all 34 ARVC patients, who were screened through a clinical evaluation. They were used to detect variations in the sequences of the plakophilin-2 genes by polymerase chain reaction amplification in combination with direct sequencing.

Results
In exon-1 of the plakophilin-2 gene, a deletion mutation (c.145_148 del GACA) was found in one family pedigree. The mutation was also found in exon-2, 4, and 11 of the plakophilin-2 gene. The QT interval dispersion of the ECG was considerably longer in the mutation group than in the non-mutation group of ARVC patients, and this result was statistically significant (P <0.05).

Conclusion
We discovered a plakophilin-2 mutation that prolongs the QT interval dispersion in the southern Chinese ARVC population.
Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas
Authors: LIU Qun , LI Ji-guang , ZHENG Xin-yu , JIN Feng , DONG Hui-ting 
Published: January 2024

Background
Biomarkers in breast neoplasms provide invaluable information regarding prognosis and help determining the optimal treatment. We have examined the possible correlation between cancer stem cell (CSC)-like markers (CD133, paired box gene 2 protein (PAX2), epithelial specific antigen (ESA)), and a new membrane estrogen receptor (G-protein coupled receptor 30 (GPR30)) in invasive ductal breast carcinomas with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers.

Methods
In 74 invasive ductal breast carcinomas, we investigated the protein expression of these molecular markers by immunohistochemistry, and their associations with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers. We studied the interrelationship between the expressions of these proteins.

Results
CD133, a putative CSC marker, was positively related to tumor size, tumor stage, and lymph node metastasis.
PAX2 was negatively correlated with tumor recurrence. ESA, one of the breast CSC markers, was an indicator of tumor recurrence. GPR30 was associated with hormone receptors. Despite the correlation between GPR30 and the nuclear estrogen receptor, the expression was dependent. Positive staining of GPR30 in tumors displayed a significant association with high C-erbB2 expression and a tendency for tumor recurrence. A positive relationship between GPR30 and CD133 existed.

Conclusion
Detecting the expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas may be of help in more accurately predicting the aggressive properties of breast cancer and determining the optimal treatment.
Development of a novel two color tracer perfusion technique for the hydrodynamic study of aqueous outflow in bovine eyes
Authors: ZHU Jing-yin , YE Wen , GONG Hai-yan 
Published: January 2024

Background
Elevation of intraocular pressure is usually associated with primary open angle glaucoma and caused by increased outflow resistance. A two-color fluorescent tracer technique was developed to investigate the hydrodynamics of aqueous humor outflow with changing intraocular pressure within the same eye, to better understand the relationship between outflow facility and effective filtration area.

Methods
Eighteen enucleated bovine eyes were first perfused at 30 mmHg with Dulbecco's phosphate-buffered saline containing 5.5 mmol/L D-glucose. After a stable baseline facility, red fluorescent microspheres (0.5 μm, 0.002% v/v) were exchanged and perfused. Eyes in the one-color control group (n=6) were immediately perfused with fixative. In the experimental group (n=6), eyes were perfused with green tracer after intraocular pressure reduced to 7 mmHg, while in the two-color control group (n=6), eyes were perfused with green tracer with intraocular pressure remaining at 30 mmHg. All 12 eyes were then perfusion-fixed. Outflow facility was continuously recorded in all eyes. Confocal images were taken along the inner wall of the aqueous plexus and the percent of the effective filtration length (PEFL; length of inner wall exhibiting tracer labeling/total length of inner wall) was measured. The relationships between outflow facility and PEFL were analyzed statistically.

Results
No significant differences were found in baseline facilities (μl·min-1·mmHg-1) among the three groups (the experimental group: 0.93±0.12; the two-color control group: 0.90±0.19; the one-color control group: 0.98±0.13). In the experimental group, the outflow facility was significantly higher at 7 mmHg (4.29±1.01) than that at 30 mmHg (1.90±0.67, P <0.001), which corresponded to a significant increase in the PEFL at 7 mmHg (54.70±8.42) from that at 30 mmHg ((11.76±4.56)%, P <0.001). The PEFL labeled by red fluorescent microspheres in the experimental group ((11.76±4.56)%) showed no significant difference from that of the one-color control group ((13.39±2.19)%, P=0.473) or the two-color control group ((11.49±4.95)%, P=0.930). The PEFL labeled by green fluorescent microspheres in the experimental group ((54.70±8.42)%) was significantly higher than that of the two color control group ((37.34±8.17)%, P=0.010). A positive correlation was found between outflow facility and PEFL(t=0.897, R
2=0.804) in the experimental group.

Conclusions
Changes in aqueous humor outflow patterns before and after a change in intraocular pressure can be successfully distinguished within the same eye using our newly developed two-color tracer perfusion technique. The PEFL showed positive correlation with the outflow facility.
Influence of insulin resistance on long-term outcomes in patients with coronary artery disease after sirolimus-eluting stent implantation
Authors: ZHAO Liang-ping , LÜ An-kang , SHEN Wei-feng , LIU Hai-feng , MA Xiao-ye , FAN Xiao-ming , ZHANG Qi 
Published: January 2024

Background
Insulin resistance (IR) is significantly associated with coronary artery disease and cardiovascular events in patients with or without type 2 diabetes mellitus. This study aimed to evaluate the influence of IR on long-term outcomes of patients undergoing percutaneous coronary intervention (PCI) with sirolimus-eluting stent (SES) implantation.

Methods
A total of 467 consecutive patients undergoing SES-based PCI were divided into IR group (n=104) and non-IR group (n=363). The patients were followed up for one year. The rate of major adverse cardiac events (MACEs) including death, non-fatal myocardial infarction and recurrent angina pectoris was compared by the log-rank test, and the independent risk factors were identified by the Cox regression analysis.

Results
MACEs occurred more frequently, and cumulative survival rate was lower in the IR group than in the non-IR group during the follow-up (all P <0.05). IR was an independent risk factor for the occurrence of cardiac death and non-fatal myocardial infarction (OR=2.76, 95% CI=1.35-5.47, P=0.034). Old age, diabetes, and multi-vessel disease were determinants for recurrent angina pectoris after PCI (P <0.05). Subgroup analysis revealed that IR (OR=3.35, 95% CI=1.07-13.59, P=0.013) and multi-vessel disease (OR=2.19, 95% CI=1.01-5.14, P=0.044) were independent risk predictors for recurrent angina pectoris in patients with diabetes after PCI.

Conclusions
IR is associated with reduced MACE-free survival and remains an independent predictor for recurrent angina pectoris after PCI with SES implantation.
Pre-hospital care-seeking in patients with acute myocardial infarction and subsequent quality of care in Beijing
Authors: SONG Li , YAN Hong-bing , HU Da-yi , YANG Jin-gang , SUN Yi-hong 
Published: January 2024

Background
Cumulative evidence demonstrates that primary percutaneous coronary intervention (PCI) is a reperfusion strategy for ST-elevation myocardial infarction (STEMI). This study was undertaken to evaluate the pre-hospital care-seeking pathway and subsequent care quality in patients with STEMI in the Beijing health care system, which offers patients a choice between seeking care in a small community hospital (SH group) or a large hospital (LH group).

Methods
Between January 1 and December 31, 2006, a cross-sectional and multicenter survey was conducted in 11 hospitals qualified as tertiary centers in Beijing and included consecutive patients with STEMI admitted within 24 hours after onset of symptoms.

Results
Among the 566 patients interviewed, 28.3% first arrived at a small community hospital and were transferred to large hospitals with the ability to perform primary PCI. The median total pre-hospital delay in the SH group (n=160) was significantly longer than in the LH group (n=406) (225 vs. 120 minutes, P <0.001). Multivariate analysis showed that interpreting symptoms to non-cardiac origin (OR, 1.996; 95% CI: 1.264-3.155), absence of history of myocardial infarction (OR, 1.595; 95% CI: 1.086-3.347), non-health insurance coverage (OR, 1.931; 95% CI: 1.079-3.012) and absence of sense of impending doom (OR, 4.367; 95% CI: 1.279-14.925) were independent predictors for choosing small hospitals. After adjusting for demographics and medical history, patients in the SH group were 1.698 times (95% CI: 1.182-3.661) less likely to receive primary PCI compared with those in the LH group.

Conclusions
Above one fourth of the STEMI patients in Beijing experienced inter-hospital transfer. Factors including symptoms interpretation, symptoms, history of myocardial infarction, and insurance coverage were associated with the patients’ pre-hospital care-seeking pathway. The patients who were transferred had longer pre-hospital delays and were less likely to receive primary PCI.