bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ectopic upper third molar embedded in a dentigerous cyst of the maxillary sinus: a case report and literature review
Authors: Al-Ani Raid M. , Aldelaimi Tahrir N. , Khalil Afrah A. , Abdulkareem Suzan M. 
Published: January 2024

Abstract
Background
Dentigerous cysts are the second most common form of a developmental cyst. These cysts might be the cause of ectopic teeth. Dentigerous cysts associated with ectopic teeth in the maxillary sinus are seldom seen in clinical practice.

Case presentation
We reported a 23-year-old woman who presented with nasal obstruction and facial pain on the left side 4 months ago. Three courses of antibiotics and analgesia were prescribed for her without improving the presenting features. Furthermore, extraction of the left upper second premolar and second molar, but the condition persisted. An orthopantogram and computerized tomography scan revealed the ectopic position of the left third upper molar tooth, which was embedded in a cystic lesion occupying the whole maxillary sinus. Removal of the cystic lesion with the ectopic tooth was performed with a Caldwell-Luc procedure. The histopathological evaluation confirmed the diagnosis of a dentigerous cyst. The presenting symptoms were resolved following surgery with no intra- or postoperative complications.

Conclusion
We are reporting another case of a dentigerous cyst occupying the whole left maxillary sinus with an ectopic left third upper molar tooth. Reporting such a case will enrich the literature regarding this rare clinical entity.
Evaluation of location of cosmetic customization in public buildings in South-West Nigeria
Authors: Adedayo Olatunde Folaranmi , Ale Ayomide Taiwo , Yahaya-Loko Nasir Muhammad , Adekunle Victor Samuel 
Published: January 2024

AbstractThe categorization of public buildings is such that it covers all buildings that are accessible to the public; however, many public buildings that are either fully or partially privately owned usually undergo some form of cosmetic customization in an attempt to communicate the aspirations of the owners or occupants of the building or the space within the building to the users. This paper aims to examine the location and aspects of the buildings that are affected by cosmetic customization as they relate to the occupants and owners of the buildings. The study adopted mixed methods of qualitative and quantitative research approach, it used both a questionnaire and observation checklist to obtain data from the selected buildings and the respondents. Eleven public categories of public buildings were selected and 30 copies of the questionnaire were administered to each category. The data was analyzed using descriptive statistics from SPSS software and the results are presented in tables and charts. It was observed that a high percentage of the customization was undertaken within the building and the ceiling aspect of the interior was the most modified part of the building. The study concluded that cosmetic customization was undertaken in all of the public buildings examined, and this action helped project the image the owners wanted to put forward as their form of brand identity using the building.
Communication Strategies of Transplant Hematologists in High-Risk Decision-Making Conversations
Authors: Rodenbach Rachel A. , Thordardottir Thorunn , Brauer Markus , Hall Aric C. , Ward Earlise , Smith Cardinale B. , Campbell Toby C. 
Published: January 2024

PURPOSE Shared decision making (SDM) is essential to empower patients with blood cancers to make goal-concordant decisions about allogeneic hematopoietic cell transplantation. This study characterizes communication strategies used by hematologists to discuss treatment options and facilitate SDM with patients in this high-risk, high-reward setting. METHODS AND MATERIALS We recruited US hematologists who routinely perform allogeneic hematopoietic cell transplant through email. Participants conducted up to an hour-long video-recorded encounter with an actor portraying a 67-year-old man with recently diagnosed high-risk myelodysplastic syndrome. We transcribed and qualitatively analyzed video-recorded data. RESULTS The mean age of participants (N = 37) was 44 years, 65% male, and 68% White. Many hematologists included similar key points in this initial consultation, although varied in how much detail they provided. Their discussion of treatment options included transplant and chemotherapy and less commonly supportive care or clinical trials. They often emphasized transplant's potential for cure, discussed transplant chronologically from pretransplant considerations through the post-transplant course, and outlined risks, complications, and major outcomes. Hematologists referred to several elements that formed the basis of treatment decision making. The strength of their treatment recommendations ranged from strong recommendations for transplant or chemotherapy to deferrals pending more information. Hematologists also varied in the extent to which they indicated the decision was physician-driven, patient-led, or shared. CONCLUSION The transplant decision-making discussion is complex. Identification of similar content areas used by hematologists can be used as the basis for a communication tool to help hematologists discuss allogeneic hematopoietic cell transplant with patients.
Negative-temperature pressure in black holes
Authors: Norte Richard A. 
Published: January 2024

Abstract
The concept of negative temperature

is unique to quantum physics and describes systems that are hotter than any positive-temperature system. For decades, negative temperatures have been shown in a number of spin systems, but experiments only recently demonstrated atomic ensembles with negative temperatures in their motional degrees of freedom. An observed behavior of such negative-temperature ensembles is that despite highly attractive forces between an arbitrary number of particles, there is a self-stabilization against collapse. Negative temperatures are only possible in quantum systems because there exists upper bounds on the energy of particles —a property not found in classical physics. Here we consider whether event horizons set up similar upper limits within black holes, giving rise to negative-temperature systems just within event horizons. Combining black-hole thermodynamics with experimentally observed negative-temperature effects could imply a quantum-based outward pressure in black holes.
Microglia Promote Inhibitory Synapse Phagocytosis in the Spinal Cord Dorsal Horn and Modulate Pain-Like Behaviors in a Murine Cancer-Induced Bone Pain Model
Authors: Zhang Zuoxia , Mao Yanting , Huang Simin , Xu Rui , Huang Yulin , Li Shuming , Sun Yu’e , Gu Xiaoping , Ma Zhengliang 
Published: January 2024

BACKGROUND:
The microglial activation has been implicated in cancer-induced bone pain. Recent studies have revealed that microglia mediate synaptic pruning in the central nervous system, where the cluster of differentiation 47-signal regulatory protein α (CD47-SIRPα) axis creates a “don’t eat me” signal and elicits an antiphagocytic effect to protect synapses against elimination. To date, the synaptic phagocytosis in microglia has never been investigated in the murine cancer-induced bone pain model. The present experiments sought to explore whether microglia phagocytize synapses in mice with bone cancer pain as well as the possible mechanisms.

METHODS:
Male C3H/HeN mice were used to induce bone cancer pain. Minocycline and S-ketamine were injected into D14. The number of spontaneous flinches (NSF) and paw withdrawal mechanical thresholds (PWMT) were measured on D0, D4, D7, D10, D14, D21, and D28. Hematoxylin and eosin staining presented bone lesions. Western blotting examined the Gephyrin, CD47, and SIRPα expression. Flow cytometry evaluated the proportion of SIRPα+ cells in the spine. Immunofluorescence and 3-dimensional reconstruction showed the Gephyrin puncta inside microglial lysosomes.

RESULTS:
Mice embedded with tumor cells induced persistent spontaneous pain and mechanical hyperalgesia. Hematoxylin and eosin staining revealed bone destruction and tumor infiltration in marrow cavities. Microglia underwent a responsive and proliferative burst (t = −16.831, P < .001). Western blotting manifested lowered Gephyrin expression in the tumor group (D4, D7, D10, D14, D21, and D28: P < .001). Immunofluorescence and 3-dimensional reconstruction showed larger volumes of Gephyrin puncta inside microglial lysosomes (t = −23.273, P < .001; t = −27.997, P < .001). Treatment with minocycline or S-ketamine exhibited pain relief and antiphagocytic effects (t = −6.191, P < .001, t = −7.083, P < .001; t = −20.767, P < .001, t = −17.080, P < .001; t = 11.789, P < .001, t = 16.777, P < .001; t = 8.868, P < .001, t = 21.319, P < .001). Last but not least, the levels of CD47 and SIRPα proteins were downregulated (D10: P = .004, D14, D21, and D28: P < .001; D10, D14, D21, and D28: P < .001). Flow cytometry and immunofluorescence substantiated reduced microglial SIRPα (t = 11.311, P < .001; t = 12.189, P < .001).

CONCLUSIONS:
Microglia-mediated GABAergic synapse pruning in the spinal cord dorsal horn in bone cancer pain mice, which might be associated with the declined CD47-SIRPα signal. Our research uncovered an innovative mechanism that highlighted microglia-mediated synaptic phagocytosis in a murine cancer-induced bone pain model.
The Extinction Image
Authors: Norton Bryan 
Published: January 2024

AbstractThis essay explores the artist Gregory Chatonsky's development of a new type of image—the extinction image. Emerging as a by-product of new technologies such as deep learning and neural nets, this nonoperative image is typified by a painstaking attempt to come to grips with the current threat of human extinction. It arises as a symptom of numerous crises endemic to the Anthropocene, providing a speculative tool for planetary thinking to develop alternatives in and through what has been called postcinema by scholars such as Steve Shaviro and Shane Denson. For Chatonsky, the Earth itself must now be imagined as a disarticulate user of postcinematic media, producing images that display a stunning indifference to the presence or absence of the human species. Close examination of Chatonsky's work will reveal a radical ecopolitics defined by a concern for what Alexander Galloway has called whatever being. Urging us to think carefully about the planetary emergency presented by climate change and geopolitical unrest, the extinction image serves as a reminder that the future of life on Earth is not a foregone conclusion.
Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures
Authors: Girolamo Daniela Di , Benavente-Diaz Maria , Murolo Melania , Grimaldi Alexandre , Lopes Priscilla Thomas , Evano Brendan , Kuriki Mao , Gioftsidi Stamatia , Laville Vincent , Tinevez Jean-Yves , Letort Gaëlle , Mella Sebastian , Tajbakhsh Shahragim , Comai Glenda 
Published: January 2024

ABSTRACT
Skeletal muscle stem cells (MuSCs) are recognised as functionally heterogeneous. Cranial MuSCs are reported to have greater proliferative and regenerative capacity when compared with those in the limb. A comprehensive understanding of the mechanisms underlying this functional heterogeneity is lacking. Here, we have used clonal analysis, live imaging and single cell transcriptomic analysis to identify crucial features that distinguish extraocular muscle (EOM) from limb muscle stem cell populations. A MyogeninntdTom reporter showed that the increased proliferation capacity of EOM MuSCs correlates with deferred differentiation and lower expression of the myogenic commitment gene Myod. Unexpectedly, EOM MuSCs activated in vitro expressed a large array of extracellular matrix components typical of mesenchymal non-muscle cells. Computational analysis underscored a distinct co-regulatory module, which is absent in limb MuSCs, as driver of these features. The EOM transcription factor network, with Foxc1 as key player, appears to be hardwired to EOM identity as it persists during growth, disease and in vitro after several passages. Our findings shed light on how high-performing MuSCs regulate myogenic commitment by remodelling their local environment and adopting properties not generally associated with myogenic cells.
Achilles Tendon Loading during Running Estimated Via Shear Wave Tensiometry: A Step Toward Wearable Kinetic Analysis
Authors: REITER ALEX J. , MARTIN JACK A. , KNURR KEITH A. , ADAMCZYK PETER G. , THELEN DARRYL G. 
Published: January 2024

ABSTRACT

Purpose
Understanding muscle–tendon forces (e.g., triceps surae and Achilles tendon) during locomotion may aid in the assessment of human performance, injury risk, and rehabilitation progress. Shear wave tensiometry is a noninvasive technique for assessing in vivo tendon forces that has been recently adapted to a wearable technology. However, previous laboratory-based and outdoor tensiometry studies have not evaluated running. This study was undertaken to assess the capacity for shear wave tensiometry to produce valid measures of Achilles tendon loading during running at a range of speeds.

Methods
Participants walked (1.34 m·s−1) and ran (2.68, 3.35, and 4.47 m·s−1) on an instrumented treadmill while shear wave tensiometers recorded Achilles tendon wave speeds simultaneously with whole-body kinematic and ground reaction force data. A simple isometric task allowed for the participant-specific conversion of Achilles tendon wave speeds to forces. Achilles tendon forces were compared with ankle torque measures obtained independently via inverse dynamics analyses. Differences in Achilles tendon wave speed, Achilles tendon force, and ankle torque across walking and running speeds were analyzed with linear mixed-effects models.

Results
Achilles tendon wave speed, Achilles tendon force, and ankle torque exhibited similar temporal patterns across the stance phase of walking and running. Significant monotonic increases in peak Achilles tendon wave speed (56.0–83.8 m·s−1), Achilles tendon force (44.0–98.7 N·kg−1), and ankle torque (1.72–3.68 N·m·(kg−1)) were observed with increasing locomotion speed (1.34–4.47 m·s−1). Tensiometry estimates of peak Achilles tendon force during running (8.2–10.1 body weights) were within the range of those estimated previously via indirect methods.

Conclusions
These results set the stage for using tensiometry to evaluate Achilles tendon loading during unobstructed athletic movements, such as running, performed in the field.
Do Credit Rating Agencies Learn from the Options Market?
Authors: Brockman Paul , Subasi Musa , Wang Jeff , Zhang Eliza 
Published: January 2024

Do credit rating agencies (CRAs) learn from the options market? We examine this question by exploring the relation between options trading activity and credit rating accuracy. We find that as options trading volume increases, credit ratings become more responsive to expected credit risk and exhibit greater ability to predict future defaults. We also find that CRAs rely more on the options market as a source of ratings-related information when firm default risk is higher, options trading is more informative, manager-provided information is of lower quality, and firm uncertainty is higher. Our results are robust to a number of sensitivity tests, including alternative measures of options trading and credit rating accuracy. We reach similar inferences using various approaches to address endogeneity issues, including difference-in-difference analyses and an instrumental variables approach. Overall, our findings are consistent with the view that CRAs incorporate unique information from the options market into their rating decisions which, in turn, improves credit rating accuracy. This paper was accepted by Brian Bushee, accounting. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.4980 .
Mental health status and related factors influencing healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis
Authors: Huang Jia , Huang Zhu-Tang , Sun Xin-Ce , Chen Ting-Ting , Wu Xiao-Tian 
Published: January 2024

BackgroundThe mental health of healthcare workers during the coronavirus-2019 pandemic was seriously affected, and the risk of mental health problems was high. The present study sought to systematically evaluate the mental health problems of healthcare workers worldwide during the pandemic and to determine the latest global frequency of COVID-19 associated mental health problems.MethodsData in the Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, Elsevier, MEDLINE, PubMed, PsycINFO and the Web of Science before November 11, 2022, were systematically searched. Cohort, case-control and cross-sectional studies were included. The meta-analysis used a random effects model to synthesize the comprehensive prevalence rate of mental health problems. Subgroup analyses were performed based on time of data collection; whether the country was or was not developed; continent; doctors and nurses; doctors/nurses vs. other healthcare workers; and psychological evaluation scale.ResultsA total of 161 studies were included, including 341,014 healthcare workers worldwide, with women accounting for 82.8%. Occupationally, 16.2% of the healthcare workers were doctors, 63.6% were nurses and 13.3% were other medical staff. During the pandemic, 47% (95% confidence interval [CI], 35–60%) of healthcare workers reported job burnout, 38% (95% CI, 35–41%) experienced anxiety, 34% (95% CI 30–38%) reported depression, 30% (95% CI, 29–31%) had acute stress disorder, and 26% (95% CI, 21–31%) had post-traumatic stress disorder.ConclusionsThe study found that there were common mental health problems among health care workers during the COVID-19 pandemic. The most common was job burnout, followed by anxiety, depression, acute stress and post-traumatic stress disorder. Although the global pandemic has been brought under control, its long-term impact on the mental health of healthcare workers cannot be ignored. Additional research is required to develop measures to prevent, monitor and treat psychological disorders among healthcare workers.
Causal relationship between COVID-19 and chronic pain: A mendelian randomization study
Authors: Fan Yuchao , Liang Xiao 
Published: January 2024

ObjectiveCOVID-19 is a highly transmissible disease that can result in long-term symptoms, including chronic pain. However, the mechanisms behind the persistence of long-COVID pain are not yet fully elucidated, highlighting the need for further research to establish causality. Mendelian randomization (MR), a statistical technique for determining a causal relationship between exposure and outcome, has been employed in this study to investigate the association between COVID-19 and chronic pain.Material and methodsThe IVW, MR Egger, and weighted median methods were employed. Heterogeneity was evaluated using Cochran’s Q statistic. MR Egger intercept and MR-PRESSO tests were performed to detect pleiotropy. The Bonferroni method was employed for the correction of multiple testing. R software was used for all statistical analyses.ResultBased on the IVW method, hospitalized COVID-19 patients exhibit a higher risk of experiencing lower leg joint pain compared to the normal population. Meanwhile, the associations between COVID-19 hospitalization and back pain, headache, and pain all over the body were suggestive. Additionally, COVID-19 patients requiring hospitalization were found to have a suggestive higher risk of experiencing neck or shoulder pain and pain all over the body compared to those who did not require hospitalization. Patients with severe respiratory-confirmed COVID-19 showed a suggestive increased risk of experiencing pain all over the body compared to the normal population.ConclusionOur study highlights the link between COVID-19 severity and pain in different body regions, with implications for targeted interventions to reduce COVID-19 induced chronic pain burden.
Measuring the effects of a nurse-led intervention on frailty status of older people living in the community in Ethiopia: A protocol for a quasi-experimental study
Authors: Kasa Ayele Semachew , Drury Peta , Chang Hui-Chen (Rita) , Lee Shu-Chun , Traynor Victoria 
Published: January 2024

Background
The recent recognition of the multidimensional features of frailty has emphasised the need for individualised multicomponent interventions. In the context of sub-Saharan Africa, few studies have examined: a) the frailty status of the older population; b) the level of frailty and its health implications and; c) the impact of a nurse-led intervention to reduce frailty.

Objectives
This study aims to design, implement, and evaluate a nurse-led intervention to reduce frailty and associated health consequences among older people living in Ethiopia.

Methods
The study will be conducted on 68 older persons using a pre-, post-, and follow-up single-group quasi-experimental design. Residents of Ethiopia, ≥60 years and living in the community will be invited to participate in a 24-week program designed to decrease frailty and associated health consequences. Data will be collected at three-time points: baseline, immediately after the intervention, and 12 weeks post-intervention. To determine the effect of the intervention, changes in frailty, nutritional status, activities of daily living, depression and quality of life scores will be measured. To measure the effect of a nurse-led intervention on the level of frailty among older people a generalised linear model (GLM) using repeated measures ANOVA will be used. Statistical significances will be set at p-values < 0.05.

Discussion
The results of this study will determine the impact of a nurse-led intervention to reduce frailty amongst community-dwelling older people living in Ethiopia. The results of this study will inform the development of future interventions designed to reduce frailty in lower-income countries.

Trial registration
The trial was registered in ClinicalTrials.gov with the identifier of NCT05754398.