bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of temperature on the life history traits of intermediate host snails of fascioliasis: A systematic review
Authors: Dube Agrippa , Kalinda Chester , Manyangadze Tawanda , Mindu Tafadzwa , Chimbari Moses John 
Published: December 2023

Background
The impact of climate change has led to variations in various biological processes, leading to altered transmission dynamics of infectious diseases, including snail-borne diseases (SBDs). Fascioliasis is one of the neglected zoonotic tropical snail-borne diseases caused by the trematode of the genus Fasciola. This review focused on laboratory experimental and model studies that evaluate the potential effect of temperature change on the ecology and biology of the intermediate host snails (IHS) of Fasciola.

Methods
A literature search was conducted on Google Scholar, EBSCOhost, and PubMed databases using predefined medical subject heading terms, Boolean operators, and truncation symbols in combination with direct keywords: Fasciolosis AND Temperature, Lymnaea OR Austropeplea OR Radix OR Galba OR Fossaria OR Pseudosuccinea AND growth, fecundity, AND survival at the global scale. Other search terms used were (Fascioliasis AND Temperature), (Lymnaea AND Temperature), (Austropeplea AND Temperature), (Fossaria AND Temperature), (Galba AND Temperature), (Pseudosuccinea AND Temperature), and (Radix AND Temperature).

Results
The final synthesis included thirty-five published articles. The studies reviewed indicated that temperature rise may alter the distribution, and optimal conditions for breeding, growth, and survival of IHS, ultimately resulting in changing the transmission dynamics of fascioliasis. The literature also confirmed that the life history traits of IHS and their interaction with the liver fluke parasites are driven by temperature, and hence climate change may have profound outcomes on the population size of snails, parasite density, and disease epidemiology.

Conclusion
We concluded that understanding the impact of temperature on the growth, fecundity, and survival of IHS may broaden our knowledge of the possible effects of climate change and hence inform fascioliasis control programs.
Trichinella spiralis cathepsin L damages the tight junctions of intestinal epithelial cells and mediates larval invasion
Authors: Liu Ruo Dan , Meng Xiang Yu , Li Chen Le , Lin Xin Zhi , Xu Qiu Yi , Xu Han , Long Shao Rong , Cui Jing , Wang Zhong Quan 
Published: December 2023

Background
Cathepsin L, a lysosomal enzyme, participates in diverse physiological processes. Recombinant Trichinella spiralis cathepsin L domains (rTsCatL2) exhibited natural cysteine protease activity and hydrolyzed host immunoglobulin and extracellular matrix proteins in vitro, but its functions in larval invasion are unknown. The aim of this study was to explore its functions in T. spiralis invasion of the host’s intestinal epithelial cells.

Methodology/principal findings
RNAi significantly suppressed the expression of TsCatL mRNA and protein with TsCatL specific siRNA-302. T. spiralis larval invasion of Caco-2 cells was reduced by 39.87% and 38.36%, respectively, when anti-TsCatL2 serum and siRNA-302 were used. Mice challenged with siRNA-302-treated muscle larvae (ML) exhibited a substantial reduction in intestinal infective larvae, adult worm, and ML burden compared to the PBS group, with reductions of 44.37%, 47.57%, and 57.06%, respectively. The development and fecundity of the females from the mice infected with siRNA-302-treated ML was significantly inhibited. After incubation of rTsCatL2 with Caco-2 cells, immunofluorescence test showed that the rTsCatL2 gradually entered into the cells, altered the localization of cellular tight junction proteins (claudin 1, occludin and zo-1), adhesion junction protein (e-cadherin) and extracellular matrix protein (laminin), and intercellular junctions were lost. Western blot showed a 58.65% reduction in claudin 1 expression in Caco-2 cells treated with rTsCatL2. Co-IP showed that rTsCatL2 interacted with laminin and collagen I but not with claudin 1, e-cadherin, occludin and fibronectin in Caco-2 cells. Moreover, rTsCatL2 disrupted the intestinal epithelial barrier by inducing cellular autophagy.

Conclusions
rTsCatL2 disrupts the intestinal epithelial barrier and facilitates T. spiralis larval invasion.
Contemporary Black Urban Music: The Revolution of Hip-Hop, Ron Westray (2023)
Authors: Zamora-Pasquier Jarelys 
Published: December 2023

Review of: Contemporary Black Urban Music: The Revolution of Hip-Hop, Ron Westray (2023)
London: First Hill Books, 250 pp.,
ISBN 978-1-83998-527-0, h/bk, $49.95
Antifungal Activity of Leaf Extract of Alchornea cordifolia Against Aspergillus flavus the causal Agent of Yam Tuber Rot
Authors: Enyiukwu David , Amadioha Anderson Chidi , Bassey Inemesit Ndarake 
Published: December 2023

Rots and mycotoxin contamination of agro-produce are prevalent in tropical world. Aspergillus flavus is a major mycotoxigenic rot contaminant of tubers in Abia state, Nigeria. Consumption of mycotoxin contaminated foodstuffs accounts for 25% of medically important human diseases in Nigeria. The objective of this study was to assess antifungal activity of Alchornea cordifolia against A. flavus a mycotoxigenic rot pathogen of stored tuber produce both in vitro and in vivo. Isolates were made from rotted yam tubers and pathogenicity test carried out to confirm A. flavus as pathogen. Five concentrations (100-500 mg mL-1) of methanol leaf extracts of the plant and thiophanate-methyl–a standard fungicide–were evaluated against the growth of the fungus in culture and pathogen-induced rot development and spread in vivo. The experiment was made up of 7 treatments and 3 replicates laid out in CRD. The plant leaf extract demonstrated varying levels of inhibition of A. flavus in vitro and rot development and spread in living tissues of yam. About 56.38%–68.22% and 67.245–80.01% inhibition was recorded by 100 mg mL-1 and 500 mg mL-1 of A. cordifolia extract for spore germination respectively whereas the same concentrations reduced rot development from 60% in the control experiment to 21.80% and 12.10% respectively which compared favorably (P<0.05) with standard fungicide, thiophanate-methyl. The plant demonstrated strong antifungal activity in vitro and minimized A. flavus induced rot advancement in living yam tissues.
Clinical applications and challenges in the field of extracellular vesicles
Authors: Nieuwland Rienk , Enciso-Martinez Agustin , Bracht Jillian W.P. 
Published: December 2023

Abstract
Body fluids contain cell-derived particles called extracellular vesicles (EVs). EVs are released by cells and are present in all body fluids (i. e. liquid biopsies). EVs contribute to physiology and pathology and offer a plethora of potential clinical applications, ranging from biomarkers to therapeutic applications. In this manuscript we provide an overview of this new and rapidly growing research field, along with its challenges and opportunities.
Crystal structure of dichlorido-tetrakis(1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol-κ
1
N)manganese(II), C60H68O4N12Cl10Mn
Authors: Fan Ze-Jing , Li Hong-Ya , Yan Biao 
Published: December 2023

Abstract
C60H68O4N12Cl10Mn, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.9262(11) Å, b = 13.7013(18) Å, c = 15.330(2) Å, α = 91.414(2)°, β = 98.951(2)°, γ = 106.688(2)°, V = 1769.3(4) Å3, Z = 1, R

gt
(F) = 0.0443, wR

ref
(F
2) = 0.1222, T = 296(2) K.
Evaluation of systemic inflammatory and fibrosis indices in Saprochaete capitata infections: a retrospective case-control study
Authors: Cakir Nuri 
Published: December 2023

Abstract

Objectives
Evaluation of inflammation and liver fibrosis by using well established indices of serum biomarkers in hepatitis caused by viral agents has been reported in recent studies. But the diagnostic performance and prediction of liver damage in S. capitata infections has not yet been reported. The aim of the current study was to investigate the levels of systemic inflammatory indices based on liver enzymes and platelets, their effectiveness in detecting S. capitata infection and its degree of damage to the liver.

Methods
We investigated the diagnostic performance of seven serum inflammation and fibrosis markers as fibrosis-4 (FIB-4) score, AST/platelet ratio (APRI), AST/ALT ratio (De Ritis ratio), albumin/ALP ratio (AAR), platelet/albumin ratio (PAR), pan-immune-inflammation value (PIV) and GGT/platelet ratio (GPR) in total 62 S. capitata infected patients using cut-offs through receiver operating characteristics (ROC) analysis.

Results
Area under the curve of FIB-4 score was statistically significantly higher than ones of De Ritis ratio, AAR, PIV, APR, GPR, APRI index in determining liver damage in patients with S. capitata. The optimal cut off point for FIB-4 score was defined that the levels above 27.57 for FIB-4 score may be used for the diagnosis of S. capitata with 89 % of sensitivity and 91 % of specificity.

Conclusions
Serum fibrosis and immune-inflammation indices are independent, useful predictors, and FIB4 score is superior to the others in the diagnosis of inflammation and liver damage in S. capitata. These biomarkers may also be useful to specialists to follow up on the medical processes of these patients.
Uncovering flow dynamic behaviors underlying oil–gas–water three phase flow using multivariate synchrosqueezing transform
Authors: OuYang Lei , Ren Weikai , Jin Ningde 
Published: December 2023

Abstract
Oil-gas-water three-phase flow is distinguished by its intricate flow pattern. The analysis of experimental observations to reveal the oil-gas-water three phase flow’s dynamic behavior remains a challenging task. In this paper, firstly, a simulation investigation to compare the multivariate pseudo-winger distribution (MPWD) and multivariate synchrosqueezing transform (MSST) is presented. The cross term may be suppressed while maintaining high time-frequency concentration, according to our research on multivariate synchrosqueezing transform. The time-frequency analysis of various vertical oil–gas–water three phase flow patterns is then conducted utilizing MSST. The results from this study reveal that in various frequency bands, slug flow, bubble flow, and churn flow exhibit considerable temporal frequency variances. The MSST can effectively uncover the intrinsic connection between signal fluctuations and flow structure, and promote the understanding of various patterns of flow.
Crystal structure and fluorescence-based sensor properties of a Metal-Organic Framework
Authors: Chang Jing-Lin , Wu Jun-Feng , Zhang Jia-Wei , Cui Kai , Liu Zhi-Qiang 
Published: December 2023

Abstract
A Metal-Organic Framework (MOF) based on a tricarboxylic acid ligand (H3L = biphenyl-2,4′,5-tricarboxylic acid), namely [Cd3(L)2(H2O)4] (1), had been prepared and characterized by elemental analysis, IR spectroscopy, powder X-ray diffraction (PXRD), thermogravimetric analyses (TGA), and single-crystal X-ray diffraction. Fluorescence studies showed that 1 has high quenching efficiency for testing acetone and Fe3+ ions in aqueous systems. Therefore, it can be used as a new type of fluorescence probe to detect solvent molecules and metal ions in water.
España, Portugal y los falsos amigos
Authors: RIVERO RODRÍGUEZ Ángel 
Published: December 2023

España y Portugal son dos países que comparten mucho en el terreno de la historia, la cultura y la geografía. Sin embargo, esa misma proximidad se ha convertido muchas veces en el principal obstáculo para que cooperen entre sí. Desde la perspectiva portuguesa, la proximidad española se ha visto permanentemente como una amenaza a la independencia de Portugal. Desde el punto de vista de España, la cercanía de Portugal ha debilitado su consideración como país extranjero y ha acentuado un sentido de comunidad no siempre bien recibido por los portugueses. De modo que Portugal siempre ha querido diferenciarse y España ha respondido siempre aproximándose. Esta es la raíz del malentendido.Este cruce de percepciones distintas sobre el valor de proximidad, da lugar a todo tipo de equívocos, pues el deseo de diferenciación de uno puede entenderse como enemistad por el otro y, a la inversa, el de aproximación del segundo como invasión por el primero. Ejemplo de esto es lo que ocurre con la palabra iberismo, una palabra que se escribe igual en ambas lenguas pero que puede significar cosas opuestas, esto es, que puede ser un falso amigo. Así en las dos lenguas iberismo señala el ideal de una integración de ambos países, pero en portugués esto implica la subordinación de la soberanía portuguesa a la española y puede vincularse a la idea de traición; mientras que en español tiene una carga política mucho menor y puede apuntar a la simple simpatía por Portugal.En este artículo quiero mostrar cómo la proximidad de España y Portugal ha sido un obstáculo en las relaciones exteriores entre los dos países peninsulares, cuya comunicación ha sido distorsionada por los falsos amigos hasta el punto de convertirse, ellos mismos, en falsos amigos. Esto es, en países a los que se presupone una cercanía de propósitos que casi nunca se ve realizada en los hechos.
Cambio climático y Derechos Humanos: el desafío de los “nuevos refugiados"
Authors: ESPÓSITO Carlos , TORRES CAMPRUBÍ Alejandra 
Published: December 2023

El cambio climático se manifiesta a través de un elenco de disrupciones medioambientales que traen aparejadas, entre otras consecuencias, desplazamientos humanos inducidos por la fragmentación del hábitat. La falta de consenso preliminar sobre la calificación del estatuto de los desplazados inducidos por el cambio climático como “refugiados” permite detectar la insuficiencia normativa actual del Derecho Internacional , en particular de aquellos dos órdenes normativos que parecen, prima facie, aplicables al caso: el Derecho Internacional de los refugiados y, subsidiariamente, los Derechos Humanos. Frente a esta “laguna normativa”, conviene abordar el elenco de propuestas hasta ahora formuladas para solventarlo, distinguiendo las que permiten defender la protección de estos desplazados por vía de desarrollo institucional, de aquellas que insisten en la necesidad de un mayor desarrollo normativo. Este proceso de búsqueda de soluciones revelará a su vez la tensión que subyace entre las racionalidades del Derecho Internacional del medio ambiente y la de los Derechos humanos, así como las limitaciones del Derecho Internacional a la hora de enfrentar fenómenos de dimensión global como es esta “nueva imagen” del fenómeno migratorio transfronterizo.
Los desarrollos académicos de las Relaciones Internacionales en Brasil: elementos sociológicos, institucionales y epistemológicos
Authors: JATOBÁ Daniel 
Published: December 2023

La disciplina de Relaciones Internacionales (RRII) fue acusada, en el pasado, de ser “la menos autorreflexiva de las ciencias sociales occidentales” y “una ciencia social estadounidense”, pero en las últimas décadas ella ha pasado por cambios significativos. Entre sus principales tendencias, destacan las contribuciones críticas alrededor de las autoimágenes y de las narrativas históricas de la disciplina, los análisis sociológicos de su desarrollo en diferentes contextos académicos nacionales, y las discusiones de corte epistemológico en la teoría de las RRII. El presente artículo es un estudio de caso de los desarrollos académicos de la disciplina en Brasil, a la luz de estos senderos abiertos recientemente. Primero son investigados la formación de un campo intelectual y el proceso de institucionalización de las ciencias sociales en el país, desde su independencia nacional hasta los años 1970, cuando fue creado el primer curso universitario de RRII. Después de quince años de existencia, el esfuerzo pionero aislado se vio acompañado de una expansión impresionante de la disciplina en el sistema universitario brasileño, cuyas razones probables también son discutidas en el texto. Finalmente, se entra una discusión de corte más bien epistemológico, presente actualmente en el país, y cuya atención recae sobre las principales alternativas para los desarrollos académicos de las RRII, teniendo en cuenta el dominio de las teorías estadounidenses en la disciplina.
Effect of postpartum drenching on plasma parameters of cows at a large-scale dairy farm
Authors: Lénárt Lea , Horváth András , Kis Tamás , Buják Dávid , Szenci Ottó 
Published: December 2023

AbstractThe aim of the present study was to explore the influence of postpartum drenching with a feed additive on the plasma concentration of biochemical parameters while factoring in prepartum rumination times (RT). One hundred and sixty-one cows were fitted with a Ruminact© HR-Tag approximately 5 days before calving. Drenching and control groups were established based on calving dates. Animals in the drenched group were treated three times (Day 1/day of calving/, Day 2, and Day 3 postpartum) using a feed additive containing calcium propionate, magnesium sulphate, yeast, potassium chloride and sodium chloride mixed in approximately 25 L of lukewarm tap water. Blood samples were collected on Days 1, 2, 3, 7 and 12. Cows with below the average RT were categorised as “low rumination” and those above it as “high rumination” animals. Drenching decreased the plasma concentrations of total protein, urea and creatinine and increased the levels of alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT) and chloride. Low rumination time prepartum resulted in higher concentrations of beta-hydroxybutyrate, total protein and activities of alkaline phosphatase and GGT, while it decreased the activity of ALT and the concentrations of calcium, magnesium, sodium and potassium. The day of lactation had an effect on all parameters except for potassium.
The Spiritual Distress of Adolescents "Men Sex Men"(MSM) Infected with HIV in Bandung
Authors: Aisyah Popy Siti , Lusiani Eli , Widiayanti Anggriyana Tri 
Published: December 2023

The prevalence of cases of HIV infection in the group of adolescents “Men Sex Men (MSM) in Indonesia has continued to increase from 2015 to 2019. The problem of decreasing physical health, feeling depressed, social stigma, stress and inconsistent behavior with religious values will create prolonged distress that hinders the quality of life. The purpose of this study was to identify spiritual distress in adolescents infected with HIV with MSM. This study was conducted with a cross-sectional approach to 84 young people living with HIV/AIDS. The sample selection technique used snowball sampling with a Spiritual questionnaire. Data analysis was conducted by using frequency distribution and Lambda test processed using a computer system. The results showed that 56% were in a state of spirituality with no disturbance, 38.1% were in moderate spiritual distress, and 6% were severe spiritual distress. The SSI score mean of respondents was 16.3 ± SD 4.9. There was a correlation between the length of diagnosis and the incidence of spiritual distress with a p-value of 0.000 and a value of r = 0.459. Spiritual distress tended to occur a lot in the early days of being diagnosed with HIV. There was no correlation between age and the incidence of spiritual distress (p = 0.097). This study showed that spiritual care support for adolescents MSM would help overcome existential problems related to HIV.
Nearly Simultaneous Pairs and Triplets of Historical Destructive Earthquakes with Distant Epicenters in the Italian Apennines
Authors: Galli Paolo 
Published: December 2023

AbstractHistorical seismic catalogs of Italy record several instances of pairs or triplets of large earthquakes (Mw&gt;6.7) along the Apennine chain, occurring on the same date or within a short time frame (days or weeks). Some of these events have mesoseismic areas tens of kilometers apart and/or seismogenic structures located more than 1–3 times the fault length away. Although in the case of aligned and/or contiguous faults, their cascading activation can be explained by variations in static Coulomb stress, in the case of distant faults, this mechanism could sometimes be replaced by what is known as dynamic triggering, which is caused by the passage of seismic waves generated by a remote source. In this study, I analyze three significant ancient seismic sequences that occurred in the south-central Apennines, suggesting that the extent of the destructive effects of these earthquakes can be attributed to remote dynamic triggering, causing the activation of different and unrelated seismogenic structures within a specific time frame.
Fuctional balancing in complete dentures- A case report revisiting the paterson’s technique
Authors: Pathiyil Varsha , Pathiyil Varsha , Preeti  , Richa  , Huda Irfanul 
Published: December 2023

: A good occlusion is the key to the comfort and longevity of a prosthesis. : This case report presents a 63 year old male patient who reported with the complaint of difficulty in chewing since past 3 months.: On examination, the patient presented with completely edentulous upper and lower arch. A detailed case history was recorded followed by, primary and secondary impressions. The maxillo-mandibular relation was recorded conventionally on wax occlusal rims. A trough was then made in the wax and filled with a mixture of dental plaster and carborundum. The mix was kept 2mm above the plane. The rims were inserted and the patient was instructed to perform lateral and protrusive movements resulting in the incorporation of the compensating curves. The recorded plaster index served as a guide for the teeth arrangement. The denture was processed and delivered with very minimal need for post insertion corrections.: According to Paterson (1923), an articulator with lateral movements is not necessary to establish a balanced occlusion when using the functional technique. The teeth arrangement is entirely dependent on the established curves for obtaining balance.: Various techniques are cited throughout the literature to provide a successful prosthesis. With all the advances in the digital era, denture fabrication is not an automated procedure. It is pertinent that the clinicians master the fundamentals of prosthesis fabrication, without which any amount of technology and/or persistence might be in vain.
Genotyping of Echinococcus granulosus Human Isolates Ob-tained from the Puncture, Aspiration, Injection, and Re-Aspiration (PAIR) Process in Türkiye
Authors: Akkaş Önder , Özgökçe Mesut , Aydemir Selahattin , Dündar İlyas , Ekici Abdurrahman 
Published: December 2023

Background: Echinococcus granulosus is spread by the excretion of cystic organs into the environment. The dog is infected via eating the cystic organ. It then contaminates the environment with eggs of E. granulosus, which are infective to humans and animals. We aimed to determine the E. granulosus genotypes that cause infection in humans in the Van region, Türkiye.
Methods: Sixty patients between 18 and 100 years of age, who underwent the puncture, aspiration, injection, re-aspiration (PAIR) procedure in the Department of Radiodiognastics of Van Yüzüncü Yıl University, Van, Türkiye were included in the study. PAIR fluids were examined microscopically and DNA was isolated from the fluids. After DNA isolation, polymerase chain reaction (PCR) was performed using primers that amplify the E. granulosus NADH dehydrogenase subunit 1 (NAD1) gene region. After sequence analysis of the PCR amplicons, Basic Local Alignment Search Tool (BLAST) was performed.
Results: In the microscopic examination, protoscolex or hook was detected in 42 (70%) of the samples. DNA was successfully extracted from all of the cyst fluids containing protoscolex and hook, and the NAD1 gene region was PCR-amplified. After using BLAST, all of the samples were determined to be an E. granulosus sensu stricto G1 genotype. Sequence comparison revealed that four (9.5%) isolate sequences showed single nucleotide polymorphism (SNP). Sequences of isolates with SNP submitted to the GenBank with accession numbers OR565864 to OR565867.
Conclusion: E. granulosus s.s. G1 genotype, known as sheep strain, is common in human hydatid disease in the Van region of Türkiye.