bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted therapies in children with renal cell carcinoma (RCC): An International Society of Pediatric Oncology—Renal Tumor Study Group (SIOP‐RTSG)‐related retrospective descriptive study
Authors: Sprokkerieft Julia , van der Beek Justine N. , Spreafico Filippo , Selle Barbara , Thebaud Estelle , Chowdhury Tanzina , Brok Jesper , Ottóffy Gábor , Sun Xiaofei , Ramírez Villar Gema L. , Sagoyan Garik , Segers Heidi , Doganis Dimitrios , Serra Annalisa , Lemelle Lauriane , Graf Norbert , Verschuur Arnauld C. , Tytgat Godelieve A. M. , van den Heuvel‐Eibrink Marry M. 
Published: December 2023

AbstractIntroductionIntroduction: Renal cell carcinoma (RCC) is a very rare pediatric renal tumor. Robust evidence to guide treatment is lacking and knowledge on targeted therapies and immunotherapy is mainly based on adult studies. Currently, the International Society of Pediatric Oncology–Renal Tumor Study Group (SIOP‐RTSG) 2016 UMBRELLA protocol recommends sunitinib for metastatic or unresectable RCC.MethodsThis retrospective study describes the effects of tyrosine kinase inhibitors (TKI), anti‐programmed cell death 1 (PD‐(L)1) monoclonal antibodies, and immunotherapeutic regimens in advanced‐stage and relapsed pediatric RCC.ResultsOf the 31 identified patients (0–18 years) with histologically proven RCC, 3/31 presented with TNM stage I/II, 8/31 with TNM stage III, and 20/31 with TNM stage IV at diagnosis. The majority were diagnosed with translocation type RCC (MiT‐RCC) (21/31) and the remaining patients mainly presented with papillary or clear‐cell RCC. Treatment in a neoadjuvant or adjuvant setting, or upon relapse or progression, included mono‐ or combination therapy with a large variety of drugs, illustrating center specific choices in most patients. Sunitinib was often administered as first choice and predominantly resulted in stable disease (53%). Other frequently used drugs included axitinib, cabozantinib, sorafenib, and nivolumab; however, no treatment seemed more promising than sunitinib. Overall, 15/31 patients died of disease, 12/31 are alive with active disease, and only four patients had a complete response. The sample size and heterogeneity of this cohort only allowed descriptive statistical analysis.ConclusionThis study provides an overview of a unique series of clinical and treatment characteristics of pediatric patients with RCC treated with targeted therapies.
Correlation of multiple endpoints in the first‐line chemotherapy of advanced gastric cancer: Pooled analysis of individual patient data from Japanese Phase III trials
Authors: Arai Hiroyuki , Takeuchi Madoka , Ichikawa Wataru , Shitara Kohei , Sunakawa Yu , Oba Koji , Koizumi Wasaburo , Sakata Yuh , Furukawa Hiroshi , Yamada Yasuhide , Takeuchi Masahiro , Fujii Masashi 
Published: December 2023

AbstractBackgroundIndividual‐level surrogates are important for management in patients treated for advanced gastric cancer (AGC). This study aimed to comprehensively investigate the correlation of multiple clinical endpoints in the first‐line chemotherapy of AGC.MethodsIndividual patient data (IPD) were collected from four Japanese Phase III trials comparing S‐1‐based first‐line chemotherapies (SPIRITS, START, GC0301/TOP‐002, and G‐SOX trials). Patients without Response Evaluation Criteria in Solid Tumors (RECIST)‐based radiological assessments were excluded. Spearman's rank correlation coefficient was tested for correlation among overall survival (OS), progression‐free survival (PFS), and postprogression survival (PPS). OS, PFS, and PPS were compared between responders (best response: complete response or partial response) and nonresponders (best response: stable disease or progressive disease).ResultsThe study included a total of 1492 patients. Eighty percent of the patients (n = 1190) received subsequent chemotherapies after the failure of each trial's treatment protocol. PFS moderately correlated with OS (Spearman correlation coefficient = 0.66, p < 0.005), whereas the correlation between PPS and OS was strong (Spearman correlation coefficient = 0.87, p < 0.005). Responders had significantly longer OS (median, 17.7 vs. 9.1 months, p < 0.005), PFS (median, 6.9 vs. 2.8 months, p < 0.005), and PPS (median, 10.5 vs. 6.0 months, p < 0.005) than nonresponders.ConclusionsOur results reacknowledged the mild surrogacy of PFS and importance of postprogression treatments in patients with AGC receiving first‐line chemotherapy. Consistent longer survival outcomes in better RECIST categories suggested that tumor response might be a useful individual‐level surrogate.
Desensitization in patients with hypersensitivity to platinum and taxane in gynecological cancers
Authors: Zwimpfer Tibor A. , Scherer Kathrin , Schötzau Andreas , Heinzelmann‐Schwarz Viola , Hartmann Karin , Vetter Marcus , Montavon Céline 
Published: December 2023

AbstractBackgroundExposure to paclitaxel and carboplatin has the risk of developing hypersensitivity reactions (HSRs), which could necessitate using less effective treatments to avoid anaphylaxis. Desensitization to platinum and taxane HSRs can be used to complete chemotherapy according to the standard regimen; therefore, this study investigated rates and benefits of successful desensitization in patients with gynecologic cancers (GC).MethodsWe collected data from 241 patients with GC who had at least one cycle of platinum or taxane chemotherapy. The rate of HSRs and successful desensitization were evaluated, and an outcome analysis was conducted.ResultsThe rate of HSRs to platinum and taxane was 6.39% and 13.07%, respectively. We observed a 100% success rate of desensitization in our cohort. Patients with HSR were significantly younger (57.1 vs. 64.9 years, p = 0.030) in the taxane cohort. Importantly, the overall survival (OS) of patients with platinum and taxane HSRs who underwent desensitization was comparable to that of patients with no HSRs (platinum vs. controls; median OS 60.36 vs. 60.39 months, p = 0.31; taxane vs. controls; OS 80.29 vs. 60.00 months, p = 0.59).ConclusionThus, we show that desensitization for platinum and taxane HSRs is safe and effective, resulting in an outcome that is well comparable to patients without HSR. Based on these observations, desensitization procedures might be considered as standard of care before switching to less effective treatment for patients with GC.
Rates of newly diagnosed breast cancer at commission on cancer facilities during the early phase of the COVID‐19 pandemic
Authors: Fefferman Marie , Kuchta Kristine , Wang Chi‐Hsiung , Nicholson Kyra , Kopkash Katherine , Pesce Catherine , Poli Elizabeth , Smith Thomas W. , Yao Katharine 
Published: December 2023

AbstractIntroductionThe objective of this study was to examine the impact of the early part of the COVID‐19 pandemic on the number of newly diagnosed breast cancer cases at Commission on Cancer (CoC)‐accredited facilities relative to the United States (U.S.) population.MethodsWe examined the incidence of breast cancer cases at CoC sites using the U.S. Census population as the denominator. Breast cancer incidence was stratified by patient age, race and ethnicity, and geographic location.ResultsA total of 1,499,806 patients with breast cancer were included. For females, breast cancer cases per 100,000 individuals went from 188 in 2015 to 203 in 2019 and then dropped to 176 in 2020 with a 15.7% decrease from 2019 to 2020. Breast cancer cases per 100,000 males went from 1.7 in 2015 to 1.8 in 2019 and then declined to 1.5 in 2020 with a 21.8% decrease from 2019 to 2020. For both females and males, cases per 100,000 individuals decreased from 2019 to 2020 for almost all age groups. For females, rates dropped from 2019 to 2020 for all races and ethnicities and geographic locations. The largest percent change was seen among Hispanic patients (−18.4%) and patients in the Middle Atlantic division (−18.6%). The stage distribution (0–IV) for female and male patients remained stable from 2018 to 2020.ConclusionThe first year of the COVID‐19 pandemic was associated with a decreased number of newly diagnosed breast cancer cases at Commission on Cancer sites.
Online psychoeducation groups for mental health promotion: Perceptions of Brazilian university students
Authors: da Silva Grasiele Cristina Lucietto , Pereira Debora Cristina dos Santos , Sousa Dália Passos , de Souza Deise Coelho , Correia‐Zanini Marta Regina Gonçalves , Scorsolini‐Comin Fabio 
Published: December 2023

AbstractObjectiveThis study aimed to understand the perceptions of university students regarding participation in an online psychoeducation group to promote mental health.MethodThis was a qualitative study that followed two groups over 8 weeks, carried out with 20 nursing students from a Brazilian public university during the COVID‐19 pandemic.ResultsThe online psychoeducation group was considered an efficient strategy for mental health promotion and an important resource for the provision of assistance to this population, especially in the pandemic scenario. The remote environment was considered welcoming and comfortable to share personal issues, and dispensing with commutes eased participation. On the contrary, some participants mentioned a lack of physical contact and difficulties with adherence/attendance, as well as the need for more meetings.Final considerationsFor this population, highly impacted by the pandemic, the online psychoeducation group was configured as a space for sharing life experiences, self‐knowledge and was designed to offer a welcoming environment, contributing to the construction of support networks in a social isolation scenario. It is recommended that these online group interventions continue to be investigated after the pandemic, especially by communicating about strengthening the welcoming actions in higher education.
Activation of Coq6p, a FAD Monooxygenase Involved in Coenzyme Q Biosynthesis, by Adrenodoxin Reductase/Ferredoxin
Authors: Gonzalez Lucie , Chau‐Duy Tam Vo Samuel , Faivre Bruno , Pierrel Fabien , Fontecave Marc , Hamdane Djemel , Lombard Murielle 
Published: December 2023

AbstractAdrenodoxin reductase (AdxR) plays a pivotal role in electron transfer, shuttling electrons between NADPH and iron/sulfur adrenodoxin proteins in mitochondria. This electron transport system is essential for P450 enzymes involved in various endogenous biomolecules biosynthesis. Here, we present an in‐depth examination of the kinetics governing the reduction of human AdxR by NADH or NADPH. Our results highlight the efficiency of human AdxR when utilizing NADPH as a flavin reducing agent. Nevertheless, akin to related flavoenzymes such as cytochrome P450 reductase, we observe that low NADPH concentrations hinder flavin reduction due to intricate equilibrium reactions between the enzyme and its substrate/product. Remarkably, the presence of MgCl2 suppresses this complex kinetic behavior by decreasing NADPH binding to oxidized AdxR, effectively transforming AdxR into a classical Michaelis‐Menten enzyme. We propose that the addition of MgCl2 may be adapted for studying the reductive half‐reactions of other flavoenzymes with NADPH. Furthermore, in vitro experiments provide evidence that the reduction of the yeast flavin monooxygenase Coq6p relies on an electron transfer chain comprising NADPH‐AdxR‐Yah1p‐Coq6p, where Yah1p shuttles electrons between AdxR and Coq6p. This discovery explains the previous in vivo observation that Yah1p and the AdxR homolog, Arh1p, are required for the biosynthesis of coenzyme Q in yeast.
Stacked Covalent Organic Ribbons Perpendicular to Graphene Oxide Sheets; a 1D‐p‐2D Design for Photocatalytic Tandem Reactions
Authors: Khazaee Zeynab , Ouyang Yi , Zhang Yan , Bogojevic Oliver , Jess Plesner Thea , Guo Zheng 
Published: December 2023

AbstractDevelopment of one dimensional covalent organic frameworks (1D‐COFs) with potential in light absorption and catalysis is still challenging, due to their rapid interpenetration to form 2D and 3D porous structures. Here we report a successful synthesis of imine‐linked 1D covalent organic ribbons (COR), using two simple linear building blocks 1,4‐Benzenediamine (Bda) and [2,2′‐Bipyridine]‐5,5′‐dicarbaldehyde (Bpy). The obtained 1D structure with nanorod morphology could keep its physicochemical characteristic properties when it is perpendicular to the surface of graphene oxide (GO) sheets (1D‐p‐2D structure). Due to an AB π–π stacking and efficient charge transfer between perpendicular 1D COR and GO sheets, the obtained nanocomposite showed strong visible light absorbance (400–700 nm) with coefficient of 4.400 M−1 cm−1 and decreased recombination rate of photogenerated reactive species by 92 %. The strategy of 1D‐p‐2D light driven system greatly enhanced the photocatalytic activity in practical applications such as both oxidation and hydrogenation tandem reactions to a rate constant of higher than 0.02 min−1. This study presents the first case of 1D covalent organic polymers grown perpendicularly on a carbon‐based layer for boosting electron mobility through the junction between the two components.
Deep reinforcement learning‐based resource allocation in multi‐access edge computing
Authors: Khani Mohsen , Sadr Mohammad Mohsen , Jamali Shahram 
Published: December 2023

SummaryNetwork architects and engineers face challenges in meeting the increasing complexity and low‐latency requirements of various services. To tackle these challenges, multi‐access edge computing (MEC) has emerged as a solution, bringing computation and storage resources closer to the network's edge. This proximity enables low‐latency data access, reduces network congestion, and improves quality of service. Effective resource allocation is crucial for leveraging MEC capabilities and overcoming limitations. However, traditional approaches lack intelligence and adaptability. This study explores the use of deep reinforcement learning (DRL) as a technique to enhance resource allocation in MEC. DRL has gained significant attention due to its ability to adapt to changing network conditions and handle complex and dynamic environments more effectively than traditional methods. The study presents the results of applying DRL for efficient and dynamic resource allocation in MEC Computing, optimizing allocation decisions based on real‐time environment and user demands. By providing an overview of the current research on resource allocation in MEC using DRL, including components, algorithms, and the performance metrics of various DRL‐based schemes, this review article demonstrates the superiority of DRL‐based resource allocation schemes over traditional methods in diverse MEC conditions. The findings highlight the potential of DRL‐based approaches in addressing challenges associated with resource allocation in MEC.
Research on cloud robot security strategy based on chaos encryption
Authors: Tang Yongwei , Ding Wei , Zhou Jun , Yu Yonghao , Hao Huijuan 
Published: December 2023

SummaryThis article proposes a security strategy based on chaos encryption for the transmission of robot data on cloud platforms. Based on chaos encryption technology, the data information collected by the robot is encrypted before transmission. After receiving the request, the cloud platform server uses chaos decryption technology to analyze the ciphertext information and obtain the original relevant data information. The security strategy proposed in this article is simple and feasible, and can resist all kinds of security attacks.
From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis
Authors: Rizzo Carla , Pace Andrea , Pibiri Ivana , Buscemi Silvestre , Palumbo Piccionello Antonio 
Published: December 2023

AbstractSynthesis of heterocyclic compounds is fundamental for all the research area in chemistry, from drug synthesis to material science. In this framework, catalysed synthetic methods are of great interest to effective reach such important building blocks. In this review, we will report on some selected examples from the last five years, of the major improvement in the field, focusing on the most important conventional catalytic systems, such as transition metals, organocatalysts, to more sustainable ones such as photocatalysts, iodine‐catalysed reaction, electrochemical reactions and green innovative methods.
Nitrogen‐doped Carbon Dots as Efficient Photocatalysts for High Selectivity of Dehalogenative Oxyalkylation of Styrene
Authors: Niu Kai‐Kai , Zhang Rong‐Zhen , Yang Xuan‐Zong , Ma Chao‐Qun , Liu Hui , Yu Shengsheng , Xing Ling‐Bao 
Published: December 2023

AbstractCarbon dots (CDs) are a type of carbon‐based luminescent material with a zero‐dimensional structure and a size of less than 10 nm, which are composed of sp2/sp3 hybrid carbon nuclei and surface functional groups. Because CDs has strong photoluminescence and good light absorption in the ultraviolet and near visible regions, it is an excellent candidate for photocatalytic applications. However, the use of nonmetallic doped CDs as photosensitizers for direct photocatalytic organic reactions has been limited to several scattered reports. Herein, we present nitrogen‐doped carbon dots (N‐CDs) that has a capability for not only produce reactive oxygen species (ROS), including superoxide anion radical (O2⋅−) and singlet oxygen (1O2), but also provide an unprecedented high activity of dehalogenative oxyalkylation of styrene with a yield of 93 %. This work develops a novel opportunity to utilize cost‐effective and easily accessible CDs for the advancement of photocatalysis.
Gastric‐type adenocarcinoma of the uterine cervix presenting in urine cytology specimens: A case report and literature review
Authors: Lee Kyung‐Hwa , Kim Nah Ihm , Nam Jong‐Hee , Kim Sung Sun 
Published: December 2023

AbstractGastric‐type endocervical adenocarcinoma (GEA) is a rare type adenocarcinoma of the uterine cervix that is unrelated to human papillomavirus (HPV). GEA is difficult to diagnose due to its bland‐looking morphological characteristics and is therefore often underdiagnosed. Although abnormal cells may be seen on cervical cytology specimens, they are rarely diagnosed as malignant and are often classified as atypical glandular cells. As a result, GEA may be diagnosed at advanced stages, with cytology samples from other organs after it has already invaded adjacent organs. Here, we report a case of GEA diagnosed by both cytological and histological examinations of urinary bladder and uterine cervix, after being identified as a non‐urothelial malignancy on a urine cytology. We also review and summarize the differential diagnoses for non‐urothelial lesions, particularly for glandular lesions observed on urinary cytology specimens, as well as the cytological and histological characteristics of GEA.
The value of a multidisciplinary consensus meeting in achieving agreement on eating disorders diagnosis at a specialized referral center
Authors: Charrat Jean Philippe , Massoubre Catherine , Gay Aurelia , Ravey Baptiste , Germain Natacha , Galusca Bogdan 
Published: December 2023

AbstractObjectiveThis study aimed to evaluate the concordance of eating disorders (EDs) diagnoses within a multidisciplinary team in a specialized hospital unit dedicated to the medical care of ED.MethodsThe study analyzed data from 608 female patients who sought consultation at the Eating Disorders Referral Center between 2017 and 2021. The diagnoses were established according to the DSM‐5 criteria by endocrinologists, psychiatrists, and finally confirmed or discussed within a monthly multidisciplinary consensus meeting (MCM). Fleiss' Kappa tests were conducted to assess inter‐raters' agreement.ResultsOverall, substantial agreement was observed between endocrinologists and psychiatrists and the MCM. A more detailed analysis revealed variations in agreement across different disorders. Certain EDs demonstrated substantial agreement (e.g., anorexia nervosa restrictive subtype), while others approached near‐perfect agreement (e.g., binge‐eating disorder). In contrast, agreement was fair to poor for anorexia nervosa binge‐purge subtype (ANBP) and slight for other specified feeding and ED. A period of temporary disagreement was noted for ANBP, partially attributed to practitioner turnover. An improvement in interdisciplinary agreement was observed for all ED diagnoses by the end of the study period.DiscussionVariations or lower levels of inter‐rater agreement may stem from atypical cases that fall on the border between two diagnoses or complex cases, as well as fluctuating symptoms. The progress observed throughout the study can be attributed in part to interdisciplinary learning, particularly facilitated by the MCM. The findings underscore the significance of striving for optimal concordance among different medical specialties to enhance patient care in ED treatment.Public SignificanceThis study scrutinizes the agreement levels of ED diagnoses among endocrinologists and psychiatrists within a multidisciplinary team at an Eating Disorders Referral Center. While substantial overall agreement was achieved, disparities or lower agreement levels were evident for certain diagnoses such as anorexia nervosa binge‐purge subtype. However, collaborative meetings led to a progressive enhancement in agreement over time. This research underscores the crucial role of a multidisciplinary team working collectively to ensure precise diagnoses and improved care for patients with EDs.
Time‐varying reliability analysis based on hybrid Kalman filtering and probability density evolution
Authors: Ghorbani Esmaeil , Afshari Sajad S. , Svecova Dagmar , Liang Xihui , Cha Young‐Jin 
Published: December 2023

AbstractThe study introduces a novel approach for time‐varying reliability analysis of structures called “hybrid UKF‐PDEM” by integrating the unscented Kalman filter (UKF) and the probability density evolution method (PDEM). The UKF estimates the displacement, velocity, stiffness, and damping parameters of a structure at each time step subjected to dynamic loading for structural damage quantification. The estimated parameters at each time step are then input into the PDEM to calculate the time‐varying probability density function (PDF) of the estimated states. The estimated PDF is used to update the uncertainty matrix of the estimated states in each iteration and to determine the time‐varying reliability curves of the structure. To demonstrate the effectiveness of the proposed method, we applied it to a numerical model of a three‐degree‐of‐freedom system and a full‐scale seven‐story building with different damage scenarios. The method is used to estimate the level of damage and calculate the corresponding reliability curve of the system over time for each damage scenario, utilizing the estimated structural responses and stiffness values. The extracted reliability values for each damage scenario follow the level of damage over time. This study shows that the newly developed method is computationally efficient for building a digital twin and enables real‐time damage identification and reliability analysis in various structural systems. The method's applicability to different types of structures highlights its versatility and potential for widespread use in assessing the integrity of buildings and infrastructure.