bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Quality of Medical Records and Associated Factors in Public Hospital of Wolayta Zone, South Ethiopia , 2023 Mixed Study
Authors: Jemal Muhidn , markos Terefe , jemal muhidn 
Published: December 2023

Abstract
Introduction:
Medical record is a multifunctional document that is used to communicate and document critical information about patients’ medical care among health care professionals. Medical record completeness is a key performance indicator that is related with delivery of health care services in the hospital. Medical recording system has faced challenges related with resources and lack of infrastructure in worldwide trend. Studies have indicated that medical record systems are lacking medical record management quality in low income countries. Therefore, this study aims to explore the quality of medical record at public hospitals in Wolaiyta zone.
Methods and materials:
Institutional based cross-sectional study concurrently with qualitative study using stratified sampling method was conducted from March 1–15, 2023. A purposive criterion sampling method key interview method was used qualitative data. A total of 406 Medical records were reviewed at three public hospitals in Wolaiyta zone. Review of medical records was done using a checklist and key informant interviews of health professionals and medical record staff. The quantitative data were collected kobo toolkits and exported and analyzed by SPSS version 26.0.the qualitative data was collected analyzed manually by thematic analysis.
Results
A total of 406 medical records were reviewed .In the assessment of quality of medical record, clinical components were lowered (76%) compared to Administrative components (87%).Majority of the respondents said that|“… Since lack of regular monitoring and evaluation process, there was problem in quality of medical records in the hospital According to the expected national standard, the study also showed that average quality of medical records of the study area was 68%. Records tertiary hospitals were 44.5% less likely to be quality record as compared to records in primary hospitals.
Conclusion
The overall quality of medical records in wolaita Zone was very low for components of the quality of medical records as per the standard of hospital requirements.
Evaluating Large Language Models in Ransomware Negotiation: A Comparative Analysis of ChatGPT and Claude
Authors: Kumamoto Takako , Yoshida Yunko , Fujima Himari 
Published: December 2023

Abstract
This study presents a comprehensive analysis of the application of Large Language Models (LLMs), specifically ChatGPT and Claude, in the context of ransomware negotiation. Ransomware, an increasingly prevalent and sophisticated cyber threat, necessitates innovative response strategies. This study examines the capabilities of these LLMs in simulating human-like negotiation tactics against ransomware attacks, focusing on two main types: cryptographic and data exfiltration ransomware. Through a series of controlled simulations, the efficacy of ChatGPT and Claude in understanding complex language constructs, formulating negotiation strategies, and their adaptability to varying ransomware scenarios is evaluated. The research highlights the strengths of these models in response accuracy, adaptability, and psychological manipulation resistance. However, it also reveals their susceptibility to producing hallucinations — instances of unrealistic or inaccurate responses. The study contributes to the understanding of AI's potential in cybersecurity, emphasizing the need for improvements in AI reliability, ethical considerations, and the integration of human oversight. The findings suggest that while LLMs hold promising potential in enhancing cyber defense mechanisms, their deployment in high-stakes scenarios like ransomware negotiations must be approached with caution and continuous oversight.
Strain-specific Features of Pleurotus Osreatus Growth in Vitro and Some of Its Biological Activities
Authors: Tetiana Krupodorova , Victor Barshteyn , Victoria Tsygankova , Mustafa Sevindik , Yaroslav Blume 
Published: December 2023

Abstract
Pleurotus ostreatus mycelium is widely used as a base for a variety of food and other products. This study focuses on P. ostreatus strains, increasing the production of their mycelium, studying some valuable biological properties in order to select the best strain. Using of nutrient media based on combination of natural waste (amaranth flour cake and wheat germ, wheat bran, chopped vermicelli and crumbs) has been increased the yield of P. ostreatus strains mycelium by 2.2–2.9 times compared to the control. P. ostreatus strains 551 and 1685 were more receptive to positive assimilation of all investigated growth regulators Ivin, Methyur and Kamethur used in concentrations ranged from 10− 6 to 10− 9 M (mol/l). The highest radical scavenging effect displayed by P. ostreatus 1685 (61 and 56%) and both of its mycelial extracts (EtOH and EtOAc) showed high phenolic content (7.17 and 6.73 mg of GAE/g). The maximal TPC (7.52 mg of GAE/g) demonstrated EtOH extract of P. ostreatus 2461. P. ostreatus 2462 is a high yielding strain that showed the maximum mycelial growth (15.0 ± 0.8 mm/day on PDA) on solid and liquid media and its EtOAc mycelial extract good inhibited growth of Escherichia coli (17.0 ± 0.9 mm). Mediocre growth had P. ostreatus 2460 but it can success suppressed Staphylococcus aureus growth (21.5 ± 0.5 mm). All used P. ostreatus strains displayed strong antagonistic activity in co-cultivation with Aspergillus niger, Candida albicans, Issatchenkia orientalis, Fusarium poae, Microdochium nivalе. Among used strains, P. ostreatus 1685 is quite tolerant to growth conditions and the most promising culture.
Diazotroph connectomics in Gulf Stream eddies supports N2 fixation in the North Atlantic
Authors: Hoerstmann Cora , Aguiar-González Borja M. , Barrillon Stéphanie , Bastos Cécile Carpaneto , Grosso Olivier , Pérez-Hernández M. D. , Doglioli Andrea M. , Petrenko Anne A. , Benavides Mar 
Published: December 2023

Abstract
Mesoscale oceanic eddies contribute to the redistribution of resources for plankton to thrive, but due to their fluid trapping capacity, eddies can also isolate plankton communities, subjecting them to rapidly changing environmental conditions. Diazotrophs, with their ability to fix dinitrogen (N2), are key members of the plankton community, providing reactive nitrogen for other organisms, particularly in large nutrient-depleted regions such as subtropical gyres. However, there is still limited knowledge about how mesoscale structures characterized by specific local environmental conditions can affect the distribution and metabolic response of diazotrophs compared to the large-scale dynamics of an oceanic region. Here, we investigated diazotroph diversity and activity within the Gulf Stream and two associated eddies, a region with intense mesoscale activity known for its significant role in nutrient transport into the North Atlantic Subtropical Gyre. We show that eddy edges are hotspots for diazotroph activity with potential community connectivity between eddies. Using a long-term mesoscale eddy database, we quantified eddies that, having shed off the Gulf Stream, occur over the summer season and estimated that they provide ~ 21 µmol N m− 2 yr− 1 to the region. Our analysis warrants to include mesoscale eddies as hotspots for reactive nitrogen input in the oceanic nitrogen cycle.
A influência da espiritualidade/religiosidade no enfrentamento da Covid-19 pelos profissionais de saúde
Authors: Biondo Chrisne Santana , Cafezeiro Amanda Sales , Bromochenkel Cattiúscia Batista , Sanches Gislene de Jesus Cruz , Santos Maria Vitória Araújo , Anjos Neta Maria Madalena Souza dos , Yarid Sérgio Donha 
Published: December 2023

Introdução: O contexto da pandemia trouxe sobrecarga aos serviços de saúde, bem como repercussões negativas que acometeram os profissionais que estavam na linha de frente. Objetivo: investigar de que forma a espiritualidade/religiosidade influenciou os profissionais de saúde no enfrentamento da Covid-19. Método: trata-se de um estudo de abordagem quanti-qualitativa, apresentando delineamento exploratório baseado na investigação e análise de dados advindos da pesquisa em unidade hospitalar de média complexidade. A obtenção dos dados foi online, no período de julho a agosto de 2021, através do aplicativo de rede social Whatsapp. O tratamento de dados quantitativos foi realizado através do software IRAMUTEC 7.0 e programa SPSS-21.0, para análise qualitativa foi realizada com Análise Textual Discursiva (ATD). Resultado: o estudo revelou que os profissionais de saúde apresentaram sentimentos como medo, ansiedade e insegurança, em contrapartida, também evidenciaram empatia, esperança e cuidado. Os participantes se autodeclaram espiritualizados e afirmaram ter contato com a temática na sua formação profissional. A maioria dos entrevistados acredita que a espiritualidade influenciará sua perspectiva de vida após a pandemia, além de apresentarem mudança na forma de pensarem sobre si, suas relações pessoais e a finitude da vida, após o evento estressor de trabalhar na linha de frente do enfrentamento da Covid-19. Conclusão: em momentos de estresse, a espiritualidade poderá auxiliar na mudança da forma de pensar e de se comportar dos indivíduos.
Palavras - Chaves: COVID-19; Espiritualidade; Pessoal de Saúde.
Saúde Mental na Escola: Reflexão Teórico-Prática
Authors: Tavares Claudia Mara de Melo , Souza Juliana Tavares e , Gama Linda Nice , Tavares Marilei de Melo , Paiva Laís Mariano de , Carvalho José Carlos 
Published: December 2023

A escola possui diversos meios de auxiliar na promoção da saúde mental dos jovens. No Brasil, o Programa Saúde na Escola é uma política intersetorial que tem um papel significativo na promoção da saúde dos escolares. Este artigo tem como objetivo refletir sobre a inserção de ações de saúde mental no âmbito escolar. Trata-se de uma reflexão baseada em experiência teórico-prática de pesquisa. Utilizou-se a abordagem qualitativa Sociopoética na prática realizada com adolescentes escolares de uma escola pública de Niterói- RJ, Brasil. A partir da literatura investigada e da experiência de campo foi possível conhecer as principais necessidades e princípios que podem nortear ações intersetoriais para a inclusão da saúde mental no Programa Saúde na Escola. Concluiu-se que a participação social, a valorização da ambiência, a sensibilização e capacitação dos agentes escolares para as questões de saúde mental, o envolvimento com o setor cultural, a participação dos profissionais de saúde da atenção básica e o empoderamento dos escolares são elementos fundamentais para uma política pública de atenção à saúde mental nas escolas.
Palavras-Chave: Adolescente; Serviços de Saúde Escolar; Saúde Mental; Promoção da Saúde.
The Dosage Recommendation of Cyclosporin in Children with Hemophagocytic
Lymphohistiocytosis based on Population Pharmacokinetic Model
Authors: Yang Yang , Li Ya-Feng , Hu Ke , Zhang Shi-Jia , Cui Jia-Fang , Huang Xue-Ting , He Su-Mei , Wang Dong-Dong , Chen Xiao 
Published: December 2023

Objectives::
Cyclosporin is one of the therapeutic regimens for hemophagocytic lymphohistiocytosis
(HLH); however, the optimal dosage of cyclosporine in children with HLH is unknown. It has been found that
piperacillin-tazobactam affects the cyclosporine pharmacokinetic process in pediatric HLH patients. Thus, the
purpose of the present study was to recommend cyclosporin dosage for pediatric HLH with and without piperacillin-
tazobactam.

Methods::
A previously established cyclosporine population pharmacokinetic model for pediatric HLH patients
has been used in this study to recommend optimal dosage based on Monte Carlo simulation. The pediatric
HLH patients have been included in eight weight groups (5, 10, 20, 30, 40, 50, 60, 70 kg) for sixteen
dosages (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 mg/kg), split into one dose or two doses.

Results::
The optimal cyclosporin dosages for children having HLH without piperacillin-tazobactam have been
found to be 15, 13, 12, 11, 10, and 9 mg/kg, split into two doses for weights of 5-7, 7-10, 10-20, 20-28, 28-45,
and 45-70 kg, respectively. For children with HLH, optimal cyclosporin dosages with piperacillin-tazobactam
have been found to be 8 and 7 mg/kg, split into two doses for weights of 5-20 and 20-70 kg, respectively.

Conclusion:
It is the first time that the cyclosporin dosage regimens for HLH in children have been developed
based on Monte Carlo simulation, and the initial dosage optimizations of cyclosporine in pediatric HLH patients
have been recommended.
Amoxicillin-loaded Nanotechnological Carriers for the Effective
Treatment of Helicobacter pylori Infection
Authors: Gautam Darsh , Talwan Poonam , Dhiman Sahil , Gill Rahul , Thakur Aparna , Dhiman Simran , Sharma Deexa , Kumar Akhil , Sharma Saksham 
Published: December 2023

Background:
The bacterium Helicobacter pylori (H. pylori) is known to cause gastroduodenal
disorders associated with the stomach lining that grows in the gastrointestinal tract, and can
cause gastritis, peptic ulcer, gastric lymphoma, and stomach cancer. Nearly 50% of people worldwide
suffer from H. pylori infection. This infection is more prominent in poor nations and undeveloped
countries, and is caused by multiple factors, such as consumption of unhygienic food, crowded living
style, etc. In the eradication treatment of gastric H. pylori infection, conventional dosage forms have
various adverse effects on patients.

Methods:
In this study, we have explored current developments in the utilization of nanotechnological
carriers for the successful management of H. pylori infection. In order to combat rising amoxicillin resistance,
this review has focused on therapeutic strategies that use cyclodextrins, niosomes, liposomes,
microspheres, nanoparticles, solid lipid nanoparticles, and nanostructure nanoparticles to improve
therapy against H. pylori.

Results:
The entrapment of amoxicillin in various nanotechnological carriers enhances its effectiveness
and reduces adverse effects. These carriers lead to targeted drug release and improve drug penetration
to the gastroduodenal disease site that locally controls and adjusts the drug release.

Conclusion:
For the effective treatment of H. pylori infection, nanotechnological carriers have provided
a new avenue for the development of innovative, high-impact, and low-dose systems. The main objective
of this review was to outline the present limitations of H. pylori therapy and new potential alternatives,
as well as to report how nanotechnological carriers may be used to overcome treatment
shortcomings.
A Biobanking System for Diagnostic Images: Architecture Development, COVID-19–Related Use Cases, and Performance Evaluation
Authors: Esposito Giuseppina , Allarà Ciro , Randon Marco , Aiello Marco , Salvatore Marco , Aceto Giuseppe , Pescapè Antonio 
Published: December 2023

Background
Systems capable of automating and enhancing the management of research and clinical data represent a significant contribution of information and communication technologies to health care. A recent advancement is the development of imaging biobanks, which are now enabling the collection and storage of diagnostic images, clinical reports, and demographic data to allow researchers identify associations between lifestyle and genetic factors and imaging-derived phenotypes.

Objective
The aim of this study was to design and evaluate the system performance of a network for an operating biobank of diagnostic images, the Bio Check Up Srl (BCU) Imaging Biobank, based on the Extensible Neuroimaging Archive Toolkit open-source platform.

Methods
Three usage cases were designed focusing on evaluation of the memory and computing consumption during imaging collections upload and during interactions between two kinds of users (researchers and radiologists) who inspect chest computed tomography scans of a COVID-19 cohort. The experiments considered three network setups: (1) a local area network, (2) virtual private network, and (3) wide area network. The experimental setup recorded the activity of a human user interacting with the biobank system, which was continuously replayed multiple times. Several metrics were extracted from network traffic traces and server logs captured during the activity replay.

Results
Regarding the diagnostic data transfer, two types of containers were considered: the Web and the Database containers. The Web appeared to be the more memory-hungry container with a higher computational load (average 2.7 GB of RAM) compared to that of the database. With respect to user access, both users demonstrated the same network performance level, although higher resource consumption was registered for two different actions: DOWNLOAD & LOGOUT (100%) for the researcher and OPEN VIEWER (20%-50%) for the radiologist.

Conclusions
This analysis shows that the current setup of BCU Imaging Biobank is well provisioned for satisfying the planned number of concurrent users. More importantly, this study further highlights and quantifies the resource demands of specific user actions, providing a guideline for planning, setting up, and using an image biobanking system.
The Effect of Remote Digital Services on Health Care Inequalities Among People Under Long-Term Dermatology Follow-Up: Cross-Sectional Questionnaire Study
Authors: Ramjee Serena , Mohamedthani Hanen , Patel Aditya Umeshkumar , Goiriz Rebeca , Harwood Catherine A , Osborne Richard H , Cheng Christina , Hasan Zeeshaan-ul 
Published: December 2023

Background
Given the expansion of remote digital dermatology services from the National Health Service, particularly during the COVID-19 pandemic, there is a need for methods that identify patients at risk of digital exclusion to guide equitable representation in service co-design processes and tailor remote services to the needs of their patient population.

Objective
This quality improvement project aims to inform the redesign of remote services to optimally support the ongoing needs of patients with chronic skin diseases, ensuring that the services are tailored to patients’ digital health literacy requirements.

Methods
We profiled the digital health literacy of 123 people with chronic skin conditions who require long-term surveillance in 2 specialist clinics (London, United Kingdom) using the Multidimensional Readiness and Enablement Index for Health Technology (READHY) questionnaire alongside the Optimizing Health Literacy and Access (Ophelia) process for hierarchical cluster analysis.

Results
The cluster analysis of READHY dimensions in responding participants (n=116) revealed 7 groups with distinct digital and health literacy characteristics. High READHY scores in groups 1 (n=22, 19%) and 2 (n=20, 17.2%) represent those who are confident with managing their health and using technology, whereas the lower-scoring groups, 6 (n=4, 3.4%) and 7 (n=12, 10.3%), depended on traditional services. Groups 3 (n=27, 23.3%), 4 (n=23, 19.8%), and 5 (n=8, 6.9%) had varying digital skills, access, and engagement, highlighting a population that may benefit from a co-designed dermatology service.

Conclusions
By identifying patient groups with distinguishable patterns of digital access and health literacy, our method demonstrates that 63.8% (n=74) of people attending specialist clinics in our center require support in order to optimize remote follow-up or need an alternative approach. Future efforts should streamline the READHY question profile to improve its practicality and use focus groups to elicit strategies for engaging patients with digital services.
Guideline-Based Cardiovascular Risk Assessment Delivered by an mHealth App: Development Study
Authors: Starnecker Fabian , Reimer Lara Marie , Nissen Leon , Jovanović Marko , Kapsecker Maximilian , Rospleszcz Susanne , von Scheidt Moritz , Krefting Johannes , Krüger Nils , Perl Benedikt , Wiehler Jens , Sun Ruoyu , Jonas Stephan , Schunkert Heribert 
Published: December 2023

Background
Identifying high-risk individuals is crucial for preventing cardiovascular diseases (CVDs). Currently, risk assessment is mostly performed by physicians. Mobile health apps could help decouple the determination of risk from medical resources by allowing unrestricted self-assessment. The respective test results need to be interpretable for laypersons.

Objective
Together with a patient organization, we aimed to design a digital risk calculator that allows people to individually assess and optimize their CVD risk. The risk calculator was integrated into the mobile health app HerzFit, which provides the respective background information.

Methods
To cover a broad spectrum of individuals for both primary and secondary prevention, we integrated the respective scores (Framingham 10-year CVD, Systematic Coronary Risk Evaluation 2, Systematic Coronary Risk Evaluation 2 in Older Persons, and Secondary Manifestations Of Arterial Disease) into a single risk calculator that was recalibrated for the German population. In primary prevention, an individual’s heart age is estimated, which gives the user an easy-to-understand metric for assessing cardiac health. For secondary prevention, the risk of recurrence was assessed. In addition, a comparison of expected to mean and optimal risk levels was determined. The risk calculator is available free of charge. Data safety is ensured by processing the data locally on the users’ smartphones.

Results
Offering a risk calculator to the general population requires the use of multiple instruments, as each provides only a limited spectrum in terms of age and risk distribution. The integration of 4 internationally recommended scores allows risk calculation in individuals aged 30 to 90 years with and without CVD. Such integration requires recalibration and harmonization to provide consistent and plausible estimates. In the first 14 months after the launch, the HerzFit calculator was downloaded more than 96,000 times, indicating great demand. Public information campaigns proved effective in publicizing the risk calculator and contributed significantly to download numbers.

Conclusions
The HerzFit calculator provides CVD risk assessment for the general population. The public demonstrated great demand for such a risk calculator as it was downloaded up to 10,000 times per month, depending on campaigns creating awareness for the instrument.