bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Behavior and Failure Analysis of Diaphragm in Diaphragm Compressor for Hydrogen Refueling Station
Authors: Liu Xiao-Ming , Liu Zhilong , Yu Yang , Wang Shunzeng 
Published: January 2024

AbstractDiaphragm compressor is widely used to pressurize hydrogen and is one of the key equipment in hydrogen refueling station. And the Diaphragm is one of the wearing parts of diaphragm compressor. The failure of the diaphragm makes the maintenance cost of diaphragm compressor high. Because of the large deflection of the diaphragm in the diaphragm compressor, its mechanical behavior has strong nonlinear characteristics, especially after considering the constraints on the diaphragm by the cavity of the cylinder head, it is difficult to accurately calculate with the analytical method. Therefore, considering the constraint condition of the cylinder, the finite element model of the diaphragm working in the diaphragm compressor is established. By the calculations of the diaphragm deformation and stress, the fractures of the hydrogen side of the diaphragm in the fault cases are analyzed. The results of static structure analysis and dynamic analysis are compared with diaphragm fault cases respectively, which shows the necessity of dynamic analysis in the failure analysis of diaphragm. Besides, the mechanical behavior of the diaphragm’s deformation indicates that the inertial effect of the diaphragm and collision between the diaphragm and the cavity cannot be ignored.
The ρ(770, 1450) → ωπ contributions for three-body decays $$ B\to {\overline{D}}^{\left(\ast \right)}\omega \pi $$
Authors: Ren Yu-Shan , Ma Ai-Jun , Wang Wen-Fei 
Published: January 2024

Abstract
The decays $$ B\to {\overline{D}}^{\left(\ast \right)}\omega \pi $$
B
→

D
¯

∗

ωπ
are very important for the investigation of ρ excitations and the test of factorization hypothesis for B meson decays. The $$ {B}^{+}\to {\overline{D}}^{\left(\ast \right)0}\omega {\pi}^{+} $$

B
+

→

D
¯

∗

0

ω

π
+

and B0 → D(*)−ωπ+ have been measured by different collaborations but without any predictions for their observables on theoretical side. In this work, we study the contributions of ρ(770, 1450) → ωπ for the cascade decays $$ {B}^{+}\to {\overline{D}}^{\left(\ast \right)0}{\rho}^{+}\to {\overline{D}}^{\left(\ast \right)0}\omega {\pi}^{+} $$

B
+

→

D
¯

∗

0

ρ
+

→

D
¯

∗

0

ω

π
+

, B0 → D(*)−ρ+ → D(*)−ωπ+ and $$ {B}_s^0\to {D}_s^{\left(\ast \right)-}{\rho}^{+}\to {D}^{\left(\ast \right)-}\omega {\pi}^{+} $$

B
s
0

→

D
s

∗

−

ρ
+

→

D

∗

−

ω

π
+

. We introduce ρ(770, 1450) → ωπ subprocesses into the distribution amplitudes for ωπ system via the vector form factor Fωπ(s) and then predict the branching fractions for the first time for concerned quasi-two-body decays with ρ(770, 1450) → ωπ, as well as the corresponding longitudinal polarization fractions ΓL/Γ for the cases with the vector $$ {\overline{D}}^{\ast 0} $$

D
¯

∗
0

or $$ {D}_{(s)}^{\ast -} $$

D

s

∗
−

in their final states. The branching fractions of these quasi-two-body decays are predicted at the order of 10−3, which can be detected at the LHCb and Belle-II experiments. The predictions for the decays B0 → D*−ρ(770)+ → D*−ωπ+ and B0 → D*−ρ(1450)+ → D*−ωπ+ agree well with the measurements from Belle Collaboration. In order to avoid the pollution from annihilation Feynman diagrams, we recommend to take the $$ {B}_s^0\to {D}_s^{\ast -}\rho {\left(770,1450\right)}^{+} $$

B
s
0

→

D
s

∗
−

ρ

770
1450

+

decays, which have only emission diagrams at quark level, to test the factorization hypothesis for B decays.
Increasing HbA1c is associated with reduced CD8+ T cell functionality in response to influenza virus in a TCR-dependent manner in individuals with diabetes mellitus
Authors: Hulme Katina D. , Tong Zhen Wei Marcus , Rowntree Louise C. , van de Sandt Carolien E. , Ronacher Katharina , Grant Emma J. , Dorey Emily S. , Gallo Linda A. , Gras Stephanie , Kedzierska Katherine , Barrett Helen L. , Short Kirsty R. 
Published: January 2024

AbstractDiabetes mellitus is on the rise globally and is a known susceptibility factor for severe influenza virus infections. However, the mechanisms by which diabetes increases the severity of an influenza virus infection are yet to be fully defined. Diabetes mellitus is hallmarked by high glucose concentrations in the blood. We hypothesized that these high glucose concentrations affect the functionality of CD8+ T cells, which play a key role eliminating virus-infected cells and have been shown to decrease influenza disease severity. To study the effect of hyperglycemia on CD8+ T cell function, we stimulated peripheral blood mononuclear cells (PBMCs) from donors with and without diabetes with influenza A virus, anti-CD3/anti-CD28-coated beads, PMA and ionomycin (PMA/I), or an influenza viral peptide pool. After stimulation, cells were assessed for functionality [as defined by expression of IFN-γ, TNF-α, macrophage inflammatory protein (MIP)-1β, and lysosomal-associated membrane protein-1 (CD107a)] using flow cytometry. Our results showed that increasing HbA1c correlated with a reduction in TNF-α production by CD8+ T cells in response to influenza stimulation in a TCR-specific manner. This was not associated with any changes to CD8+ T cell subsets. We conclude that hyperglycemia impairs CD8+ T cell function to influenza virus infection, which may be linked with the increased risk of severe influenza in patients with diabetes.
Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer
Authors: Gong Hui , Chen Shaojing , Liu Shuguang , Hu Qianying , Li Yixuan , Li Yifan , Li Guiqiu , Huang Kaimeng , Li Riqing , Fang Lishan 
Published: January 2024

AbstractColorectal cancer (CRC) is characterized by a complex tumor inflammatory microenvironment, while angiogenesis and immunosuppression frequently occur concomitantly. However, the exact mechanism that controls angiogenesis and immunosuppression in CRC microenvironment remains unclear. Herein, we found that expression levels of lipid raft protein STOML2 were increased in CRC and were associated with advanced disease stage and poor survival outcomes. Intriguingly, we revealed that STOML2 is essential for CRC tumor inflammatory microenvironment, which induces angiogenesis and facilitates tumor immune escape simultaneously both in vitro and in vivo. Moreover, tumors with STOML2 overexpression showed effective response to anti-angiogenesis treatment and immunotherapy in vivo. Mechanistically, STOML2 regulates CRC proliferation, angiogenesis, and immune escape through activated NF-κB signaling pathway via binding to TRADD protein, resulting in upregulation of CCND1, VEGF, and PD-L1. Furthermore, treatment with NF-κB inhibitor dramatically reversed the ability of proliferation and angiogenesis. Clinically, we also observed a strong positive correlation between STOML2 expression and Ki67, CD31, VEGFC and PD-1 of CD8+T cell expression. Taken together, our results provided novel insights into the role of STOML2 in CRC inflammatory microenvironment, which may present a therapeutic opportunity for CRC.
Polynomial Equations for Additive Functions I: The Inner Parameter Case
Authors: Gselmann Eszter , Kiss Gergely 
Published: January 2024

AbstractThe aim of this sequence of work is to investigate polynomial equations satisfied by additive functions. As a result of this, new characterization theorems for homomorphisms and derivations can be given. More exactly, in this paper the following type of equation is considered $$\begin{aligned} \sum _{i=1}^{n}f_{i}(x^{p_{i}})g_{i}(x^{q_{i}})= 0 \qquad \left( x\in \mathbb {F}\right) , \end{aligned}$$

∑

i
=
1

n

f
i

(

x

p
i

)

g
i

(

x

q
i

)

=
0

x
∈
F

,

where n is a positive integer, $$\mathbb {F}\subset \mathbb {C}$$

F
⊂
C

is a field, $$f_{i}, g_{i}:\mathbb {F}\rightarrow \mathbb {C}$$

f
i

,

g
i

:
F
→
C

are additive functions and $$p_i, q_i$$

p
i

,

q
i

are positive integers for all $$i=1, \ldots , n$$

i
=
1
,
…
,
n

.
Urinary Incontinence in Midlife According to Weight Changes Across and After Childbearing Years
Authors: Taastrøm Katja , Kjeldsen Anne Cathrine , Hjorth Sarah , Gommesen Ditte , Axelsen Susanne M. , Nohr Ellen A. 
Published: January 2024

Abstract
Introduction and Hypothesis
The objective was to investigate how weight change across and after the childbearing years was associated with urinary incontinence (UI) in midlife.

Methods
Data were obtained from 35,645 women responding to the Maternal Follow-up questionnaire in the Danish National Birth Cohort in 2013–2014. Outcome was self-reported UI and its subtypes. Exposures were changes in body mass index (BMI) across and after the childbearing years. Adjusted odds ratios were estimated using logistic regression.

Results
At follow-up, the mean age was 44 years and 32% experienced UI. Compared with stable weight, weight gain across the childbearing years of > 1 to 3, > 3 to 5 or > 5 BMI units increased the odds of any UI by 15%, 27%, and 41% respectively. For mixed UI, the odds increased by 23%, 41%, and 68% in these groups. Weight gain after childbearing showed the same pattern, but with a higher increase in the odds of mixed UI (25%, 60%, and 95% in the respective groups). Women with any weight loss during this period had 9% lower odds of any UI than women with a stable weight.

Conclusions
Weight gain across and after childbearing increased the risk of UI in midlife, especially the subtype mixed UI. Weight loss after childbearing decreased the risk.
Uncertainty quantification for random domains using periodic random variables
Authors: Hakula Harri , Harbrecht Helmut , Kaarnioja Vesa , Kuo Frances Y. , Sloan Ian H. 
Published: January 2024

AbstractWe consider uncertainty quantification for the Poisson problem subject to domain uncertainty. For the stochastic parameterization of the random domain, we use the model recently introduced by Kaarnioja et al. (SIAM J. Numer. Anal., 2020) in which a countably infinite number of independent random variables enter the random field as periodic functions. We develop lattice quasi-Monte Carlo (QMC) cubature rules for computing the expected value of the solution to the Poisson problem subject to domain uncertainty. These QMC rules can be shown to exhibit higher order cubature convergence rates permitted by the periodic setting independently of the stochastic dimension of the problem. In addition, we present a complete error analysis for the problem by taking into account the approximation errors incurred by truncating the input random field to a finite number of terms and discretizing the spatial domain using finite elements. The paper concludes with numerical experiments demonstrating the theoretical error estimates.
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence
Authors: Bassi Marta , Bilel Sabrine , Tirri Micaela , Corli Giorgia , Di Rosa Fabiana , Gregori Adolfo , Alkilany Alaaldin M. , Rachid Ousama , Roda Elisa , Zauli Giorgio , Locatelli Carlo Alessandro , Marti Matteo 
Published: January 2024

Abstract
Rationale
The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as “Moxy”) is a new psychedelic tryptamine first identified on Italian national territory in 2014. Its hallucinogen effects are broadly well-known; however, only few information is available regarding its pharmaco-toxicological effects.

Objectives
Following the seizure of this new psychoactive substances by the Arm of Carabinieri and the occurrence of a human intoxication case, in the current study we had the aim to characterize the in vivo acute effects of systemic administration of 5-MeO-MiPT (0.01–30 mg/kg i.p.) on sensorimotor (visual, acoustic, and overall tactile) responses, thermoregulation, and stimulated motor activity (drag and accelerod test) in CD-1 male mice. We also evaluated variation on sensory gating (PPI, prepulse inhibition; 0.01–10 mg/kg i.p.) and on cardiorespiratory parameters (MouseOx and BP-2000; 30 mg/kg i.p.). Lastly, we investigated the in silico ADMET (absorption, distribution, metabolism, excretion, toxicity) profile of 5-MeO-MiPT compared to 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) and N,N-dimethyltryptamine (DMT).

Results
This study demonstrates that 5-MeO-MiPT dose-dependently inhibits sensorimotor and PPI responses and, at high doses, induces impairment of the stimulated motor activity and cardiorespiratory changes in mice. In silico prediction shows that the 5-MeO-MiPT toxicokinetic profile shares similarities with 5-MeO-DIPT and DMT and highlights a cytochrome risk associated with this compound.

Conclusions
Consumption of 5-MeO-MiPT can affect the ability to perform activities and pose a risk to human health status, as the correspondence between the effects induced in mice and the symptoms occurred in the intoxication case suggests. However, our findings suggest that 5-MeO-MiPT should not be excluded from research in the psychiatric therapy field.
A systematic review for the evidence of recommendations and guidelines in hybrid nuclear cardiovascular imaging
Authors: Besson Florent L. , Treglia Giorgio , Bucerius Jan , Anagnostopoulos Constantinos , Buechel Ronny R. , Dweck Marc R. , Erba Paula A. , Gaemperli Oliver , Gimelli Alessia , Gheysens Olivier , Glaudemans Andor W. J. M. , Habib Gilbert , Hyafil Fabian , Lubberink Mark , Rischpler Christopher , Saraste Antti , Slart Riemer H. J. A. 
Published: January 2024

Abstract
Objectives
This study aimed to evaluate the level of evidence of expert recommendations and guidelines for clinical indications and procedurals in hybrid nuclear cardiovascular imaging.

Methods
From inception to August 2023, a PubMed literature analysis of the latest version of guidelines for clinical hybrid cardiovascular imaging techniques including SPECT(/CT), PET(/CT), and PET(/MRI) was performed in two categories: (1) for clinical indications for all-in primary diagnosis; subgroup in prognosis and therapy evaluation; and for (2) imaging procedurals. We surveyed to what degree these followed a standard methodology to collect the data and provide levels of evidence, and for which topic systematic review evidence was executed.

Results
A total of 76 guidelines, published between 2013 and 2023, were included. The evidence of guidelines was based on systematic reviews in 7.9% of cases, non-systematic reviews in 47.4% of cases, a mix of systematic and non-systematic reviews in 19.7%, and 25% of guidelines did not report any evidence. Search strategy was reported in 36.8% of cases. Strengths of recommendation were clearly reported in 25% of guidelines. The notion of external review was explicitly reported in 23.7% of cases. Finally, the support of a methodologist was reported in 11.8% of the included guidelines.

Conclusion
The use of evidence procedures for developing for evidence-based cardiovascular hybrid imaging recommendations and guidelines is currently suboptimal, highlighting the need for more standardized methodological procedures.
Wild and captive immature orangutans differ in their non-vocal communication with others, but not with their mothers
Authors: Fröhlich Marlen , van Noordwijk Maria A. , Mitra Setia Tatang , van Schaik Carel P. , Knief Ulrich 
Published: January 2024

Abstract
In many group-living species, individuals are required to flexibly modify their communicative behaviour in response to current social challenges. To unravel whether sociality and communication systems co-evolve, research efforts have often targeted the links between social organisation and communicative repertoires. However, it is still unclear which social or interactional factors directly predict communicative complexity. To address this issue, we studied wild and zoo-housed immature orangutans of two species to assess the impact of the socio-ecological setting on the production of non-vocal signal repertoires. Specifically, we compared repertoire size, dyadic repertoire similarity, and number of social goals (i.e. observer’s estimate of the signaller’s intended interaction outcome) for communicative interactions with mothers versus other conspecifics, controlling for critical individual and environmental factors. In this small sample of immature orangutans, wild-captive contrasts were statistically significant only for other-directed repertoires, but not for mother-directed repertoires, and not for the number of social goals that immatures communicated towards. While the repertoires of individuals living in the same research setting were more similar than those living in contrasting settings, this difference was most pronounced for other-directed repertoires of the less socially tolerant orangutan species. These results suggest that the boosted interactional opportunities in captivity rather than mere differences in environmental affordances or communicative needs drive the wild-captive contrast in orangutan communicative repertoires. Overall, this fine-grained analysis of repertoires further underscores that not only a species’ social organisation but also the targeted audience may have a profound impact on communicative behaviour.

Significance statement
Navigating a dynamic social environment often requires flexible signal use. While it has repeatedly been shown that the social organisation and structure of species predict the complexity of their communication systems, the mechanisms underlying these relationships are largely unknown. Because targeted studies to assess this issue in great apes are difficult, we take an alternative approach here: we compare the same species living in the wild and in artificial habitats in captivity. This contrast allows a direct test of how repertoires respond to the relevant difference in socio-ecological conditions. Our results show that the diversity of interaction partners (i.e. social opportunities), but not the diversity of social goals (i.e. possible interaction outcomes) or the broader physical opportunities (i.e. safe ground use), predict the size and consistency of wild and captive signalling repertoires.
Progression of arterial calcifications: what, where, and in whom?
Authors: van der Toorn Janine E. , Vernooij Meike W. , Ikram M. Arfan , Kavousi Maryam , Bos Daniel 
Published: January 2024

Abstract
Objectives
There is a lack of information on the development of arteriosclerosis over time. This study aims to assess long-term sex-specific changes in arterial calcifications in five arteries, and the influence of cardiovascular risk factors hereon.

Methods
From a population-based cohort, 807 participants (mean baseline age, 65.8; SD, 4.2) underwent a non-contrast computed tomography (CT) examination between 2003 and 2006, and after a median follow-up of 14 years. We assessed incidences and changes in volumes of coronary artery calcification (CAC), aortic arch calcification (AAC), extracranial (ECAC) and intracranial carotid artery calcification (ICAC), and vertebrobasilar artery calcification (VBAC). We investigated the simultaneous presence of severe progression (upper quartile of percentual change volumes). Associations of cardiovascular risk factors with changes in calcification volumes were assessed using multivariate linear regression models.

Results
The difference in AAC was most substantial; the median volume (mm3) increased from of 129 to 916 in men and from 93 to 839 in women. For VBAC, no change in volumes was observed though more than a quarter of participants without baseline VBAC developed VBAC during follow-up. Severe progression was most often observed in only one artery at the same time. Hypertension was most consistently associated with increase in calcifications. Associations of diabetes, hypercholesterolemia, and smoking with changes in calcifications varied across arteries and sex.

Conclusions
We found a considerable incidence and increase in volumes of calcifications in different arteries, over a 14-year time interval. Cardiovascular risk factors were associated with increase of calcifications with sex-specific differential effects across arteries.

Clinical relevance statement
There is a considerable incidence and increase in volumes of calcifications in different arteries, over a 14-year time interval. Cardiovascular risk factors are associated with increase of calcifications with sex-specific differential effects across arteries; thus, assessing changes in only one artery may thus not provide a good reflection of the systemic development of arteriosclerosis.

Key Points
• Assessing change in arterial calcification in only one artery does not reflect the systemic development of arterial calcification.
• Cardiovascular risk factors are associated with progression of arterial calcifications.
• Progression of arterial calcification is sex and artery-specific.

Graphical Abstract
Viscosity effects and confined cochlea-like geometry in laser-induced cavitation dynamics
Authors: Lengert Liza , Lohmann Hinnerk , Johannsmeier Sonja , Ripken Tammo , Maier Hannes , Heisterkamp Alexander , Kalies Stefan 
Published: January 2024

AbstractOn the path to an optoacoustic hearing implant for stimulation of residual hearing, one possibility for tone generation in liquids is the concatenation of acoustic click events, which can be realized i. a. by the acoustic transients that accompany an optical breakdown. The application of a viscous gel is helpful in this context, as this results in an attenuation of the distortion of tone quality caused by higher harmonic components. To further understand the underlying cavitation bubble dynamics both in the viscous gel and in a confined volume that is dimensioned similarly to the human cochlea, a numerical model built in OpenFOAM was adapted and compared to additional experiments. Experimentally, the acoustic transients were generated by optical breakdown by nanosecond laser pulses with a pulse duration of 0.7 ns and a wavelength of 1064 nm. The pulses were focused on a viscous gel inside a water container. The pressure transients were measured by a needle hydrophone. The comparison of the bubble dynamics in different viscosities between the model and the experiment shows that, except for high viscosities, the experimental observations could be modeled by the simulation. We assume that the maximum size of the cavitation bubble strongly decreases with increasing viscosity, which can be used for high-frequency attenuation as reported in our previous research. In conclusion, this study aims at an application-oriented realization of the numerical cavitation bubble dynamics model to understand the experimental findings on the pathway to an optoacoustic hearing implant.