bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of eosinophilia in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab: Prediction of immune‐related adverse events and favorable outcome
Authors: Ueki Yushi , Ohshima Shusuke , Omata Jo , Yokoyama Yusuke , Takahashi Takeshi , Shodo Ryusuke , Yamazaki Keisuke , Horii Arata 
Published: October 2023

AbstractIntroductionImmune‐related adverse events (irAEs) are prognostic factors for patients on nivolumab. However, predictors of irAEs have not yet been identified. We aimed to investigate the predictors of irAEs occurrence and nivolumab discontinuation due to irAEs.MethodsSixty‐two patients with recurrent/metastatic head and neck squamous cell carcinoma received nivolumab therapy between June 2017 and December 2020. Treatment outcome was compared between the groups with or without irAEs. The irAE (+) group was further divided by nivolumab discontinuation. Progression‐free survival (PFS) and overall survival (OS) were compared between the groups. Predictors of irAE occurrence were analyzed.ResultsTwenty‐one patients (33.9%) developed irAEs, and six (28.6%) discontinued nivolumab due to severe irAEs. The irAE (+) group had significantly longer PFS and OS than the irAE (−) group (median PFS, 12.7 vs. 1.9 months; median OS, 33.1 vs. 12.8 months). The treatment outcomes in the discontinuation group were comparable to those in the non‐discontinuation group. The maximum absolute eosinophil count (AEC) during nivolumab therapy was significantly higher in the irAE (+) group than in the irAE (−) group (548.8 vs. 182) and higher in the discontinuation group than in the non‐discontinuation group (729.3 vs. 368.6). The receiver operating characteristic curve showed that the maximum AEC had a moderate‐to‐high accuracy for predicting irAE occurrence (area under the curve [AUC], 0.757) and nivolumab discontinuation (AUC, 0.893).DiscussionMonitoring AEC during nivolumab therapy may be useful in predicting irAE occurrence, nivolumab discontinuation, and disease prognosis.
Trends in medical care utilization in patients with cancer: An analysis of real‐world data in a tertiary hospital in Korea, 2014–2019
Authors: Won Jung‐Hyun , Chung Tae Kyu , Lee Joochul , Yoon Sangwon , Jeon Yoomin , Lee Howard 
Published: October 2023

AbstractBackgroundRising costs of cancer treatments challenge even areas with universal health coverage. There's a need to assess current medical care utilization trends among patients with cancer to guide public health policy, resource allocation, and set informed healthcare goals.MethodsWe analyzed the latest trends in medical care utilization by cancer patients in four areas—drugs, radiation therapy (RT), surgery, and diagnostic procedures—using clinical databases extracted from electronic medical records of a tertiary hospital in Korea between 2014 and 2019. Compound adjusted growth rates (CAGR) were computed to capture the annual growth over the study period.ResultsA total of 74,285 cancer patients were identified, with 40.3% (29,962), 14.2% (10,577), 31.1% (23,066), and 92.6% (68,849) of patients having received at least one anticancer agent, RT, surgery, and diagnostic procedure, respectively, over the period. We observed a 1.7‐fold increase in the use of targeted · immune‐oncology agents (from 6.8% to 11.6%) and a 21‐fold increase (from 3.0% in 2014 to 65.7%) in intensity‐modulated RT (IMRT) use over the period. In contrast, we observed a continuous decrease in the proportion of patients who underwent surgical treatment from 12.2% in 2014 to 10.9% in 2019. This decrease was particularly noticeable in patients with colon cancer (from 28.5% to 24.2%) and liver cancer (from 4.1% to 2.9%).ConclusionFrom 2014 to 2019, there was a significant rise in the use of targeted · immune‐oncology agents and IMRT, alongside a decline in surgeries. While targeted · immune‐oncology agents and IMRT may offer promising outcomes, their financial impact and potential for overuse necessitate careful oversight and long‐term cost‐effectiveness studies.
Predictive models of long‐term survival outcomes following radical cystectomy
Authors: Ohtsu Akira , Arai Seiji , Fujizuka Yuji , Miyazawa Yoshiyuki , Nomura Masashi , Sekine Yoshitaka , Koike Hidekazu , Matsui Hiroshi , Shibata Yasuhiro , Ito Kazuto , Suzuki Kazuhiro 
Published: October 2023

AbstractBackgroundIdentifying the likelihood of life‐threatening recurrence after radical cystectomy by reliable and user‐friendly predictive models remains an unmet need in the clinical management of invasive bladder cancer.MethodsA total of 204 consecutive patients undergoing open radical cystectomy (ORC) for bladder cancer were retrospectively enrolled between May 2005 and August 2020. Clinicopathological and peri‐ORC therapeutic data were extracted from clinical records. We explored predictive factors that significantly affected the primary endpoint of overall survival (OS) and secondary endpoints of cancer‐specific survival (CSS) and recurrence‐free survival (RFS).ResultsDuring a median follow‐up of 3.9 years, 42 (20.6%) and 10 (4.9%) patients died due to bladder cancer and other causes, respectively. Five‐year RFS, CSS, and OS were 66.5%, 77.6%, and 75.4%, respectively. Pathological T and N categories and lymphovascular invasion (LVI) significantly affected RFS by Cox regression analysis. Accordingly, clinical T and pathological N categories and LVI significantly affected CSS. Clinical T and pathological N categories, LVI, age, and ORC tumor grade significantly affected OS. Based on the assessment score for each independent risk factor, we developed the Gunma University Oncology Study Group (GUOSG) score, which predicts RFS, CSS, and OS. The GUOSG score classified four groups for RFS, three for CSS, and five for OS, with statistically significant distribution for nearly all comparisons.ConclusionsThe GUOSG model is helpful to show individualized prognosis and functions as a risk‐stratified historical cohort for assessing the lifelong efficacy of new salvage treatment regimens.
Discovery of 14‐3‐3 PPI Stabilizers by Extension of an Amidine‐Substituted Thiophene Fragment
Authors: Wu Qi , Centorrino Federica , Guillory Xavier , Wolter Madita , Ottmann Christian , Cossar Peter J. , Brunsveld Luc 
Published: October 2023

AbstractProtein‐protein interaction (PPI) modulation is a promising approach in drug discovery with the potential to expand the ‘druggable’ proteome and develop new therapeutic strategies. While there have been significant advancements in methodologies for developing PPI inhibitors, there is a relative scarcity of literature describing the ‘bottom‐up’ development of PPI stabilizers (Molecular Glues). The hub protein 14‐3‐3 and its interactome provide an excellent platform for exploring conceptual approaches to PPI modulation, including evolution of chemical matter for Molecular Glues. In this study, we employed a fragment extension strategy to discover stabilizers for the complex of 14‐3‐3 protein and an Estrogen Receptor alpha‐derived peptide (ERα). A focused library of analogues derived from an amidine‐substituted thiophene fragment enhanced the affinity of the 14‐3‐3/ERα complex up to 6.2‐fold. Structure‐activity relationship (SAR) analysis underscored the importance of the newly added, aromatic side chain with a certain degree of rigidity. X‐ray structural analysis revealed a unique intermolecular π–π stacking binding mode of the most active analogues, resulting in the simultaneous binding of two molecules to the PPI binding pocket. Notably, analogue 11 displayed selective stabilization of the 14‐3‐3/ERα complex.
Veneer crowns in anterior endodontically‐treated teeth: A case report with 1‐year follow‐up
Authors: Karimi Mandana , Hashemikamangar Sedigheh Sadat , Farahani Shakiba 
Published: October 2023

Key Clinical MessageVeneer crowns can be used in anterior endodontically‐treated teeth with light occlusal force and enamel substrate consideration as a more conservative approach instead of conventional all ceramic crowns.AbstractAll‐ceramic anterior crowns and veneers have been used widely in dentistry with high clinical success rate. The development of new reinforced ceramics in recent years has led to more use of extended defect‐oriented preparation designs, that is, extended veneers, instead of full crown preparations which are less invasive. A veneer crown is simply a veneer that covers the entire tooth. The preparation preserves remaining enamel and uses a conservative preparation design. Its indication should be carefully raised taking into consideration various factors. The preparation design is crucial to ensure longevity of such restoration. The balance is between sufficient preparation for the material thickness and adequate strength against occlusal load and the enamel preservation. A 24‐year‐old man referred to the restorative department of the Dentistry School of Tehran University of Medical Sciences complaining from his poor esthetics in the maxillary incisors. In clinical and radiographic evaluation, he had open bite, composite discoloration due to corrosion of the pre‐fabricated posts in all four incisors, a periapical lesion in tooth 21 and under‐filled root canal therapy in tooth 22. All four posts and composite restorations were removed and teeth 21 and 22 were retreated. Although the amount of remaining tooth tissue was low, it had enough enamel thickness, especially in the buccal area. Taking into consideration this mixed enamel and dentin substrate, endodontics access, esthetics needs and canine guidance occlusion with no parafunction history, bonded lithium disilicate veneer crowns were selected to restore the maxillary incisors. A 12‐month follow‐up showed promising clinical (healthy gingival tissue and successful restorations) and radiographic (reduced periapical lesion) outcomes.
Unusual cause of myocardial infarction following transcatheter aortic valve replacement
Authors: Shah Neeraj , Nifong L. Wiley 
Published: October 2023

Key Clinical MessageLeft coronary artery embolism from aortic valve leaflet tissue mass is a rare but potentially life‐threatening complication following transcatheter aortic valve replacement. It is important for interventional cardiologists to be aware of this rare complication for rapid identification and prompt treatment which is the key to a successful outcome.AbstractAn 81‐year‐old female presented for elective transcatheter aortic valve replacement (TAVR) for severe low‐flow low‐gradient aortic stenosis. Immediately post‐procedure, she developed unexplained, persistent hypotension. There was no bleeding. There was no aortic injury. Activated clotting time was in therapeutic range. Coronary angiography revealed hazy filling defects in left anterior descending and left circumflex. Intravascular ultrasound showed heterogeneous, hypoechoic mass with mild calcification consistent with embolized valve leaflet tissue. This was treated with emergent percutaneous coronary intervention with excellent results. Left coronary artery embolism from aortic valve leaflet tissue is a rare, but potentially life‐threatening complication following TAVR. Prompt recognition is key to a successful outcome.
Layered Double Hydroxide Nanosheets: Synthesis Strategies and Applications in the Field of Energy Conversion
Authors: Wang Yindong , Ying Zhixuan , Gao Yushuan , Shi Le 
Published: October 2023

AbstractIn recent years, layered double hydroxides (LDH) nanosheets have garnered substantial attention as intriguing inorganic anionic layered clay materials. These nanosheets have captured the attention of researchers due to their unique physicochemical properties. This review aims to showcase the latest advancements in laboratory research concerning LDH nanosheets, with a specific emphasis on their methods of preparation. This review provides detailed insights into the factors influencing the anionic conductivity of LDH, along with delineating the applications of LDH nanosheets in the realm of energy conversion. Notably, the review highlights the crucial role of LDH nanosheets in the oxygen evolution reaction (OER), a vital process in water splitting and diverse electrochemical applications. The review emphasizes the significant potential of LDH nanosheets in enhancing supercapacitor technology, owing to their high surface area and exceptional charge storage capacity. Additionally, it elucidates the prospective application of LDH nanosheets as anion exchange membranes in anion exchange membrane fuel cells, potentially revolutionizing fuel cell performance through improved efficiency and stability facilitated by enhanced ion transport properties.
Direct Conversion of CO2into Alcohols Using Cu‐Based Zeolite Catalysts
Authors: Iltsiou Dimitra , Mielby Jerrik , Kegnæs Søren 
Published: October 2023

AbstractThe direct hydrogenation of CO2into alcohols is an attractive but challenging catalytic reaction. Herein, it was shown that Cu nanoparticles supported on MFI and BEA zeolites have high catalytic activity and selectivity for converting CO2into ethanol and isopropanol. Furthermore, we investigated the effect of introducing mesopores via carbon templating and encapsulating the Cu nanoparticles via subsequent recrystallization. All the catalysts were characterized by N2physisorption, XRD, SEM, TEM, NH3TPD, XPS, and XRF, before we tested them in a high‐pressure water‐filled autoclave with a constant partial pressure of CO2(1 MPa) and an increasing partial pressure of H2(3–5 MPa). In general, the mesoporous zeolite catalysts resulted in a higher CO2conversion and selectivity toward ethanol than their non‐mesoporous equivalents, while the recrystallized catalyst with encapsulated Cu nanoparticles had a higher selectivity towards isopropanol. For example, Cu@m‐S1 showed the highest isopropanol productivity among the recrystallized mesoporous zeolites, corresponding to 20.51 mmol g−1 h−1under the given reaction conditions. These findings highlight the importance of mesopores in zeolite catalysts for CO2hydrogenation to alcohols and point a new direction for further research and development.
Reduced TiO2 Nanotubes/Silk Fibroin/ZnO as a Promising Hybrid Antibacterial Coating
Authors: Păun Angela Gabriela , Popescu Simona , Ungureanu Camelia , Trusca Roxana , Pirvu Cristian 
Published: October 2023

AbstractThe current research aims to elucidate the influence of reduction process of TiO2 nanostructures on the surface properties of a bioinspired Ti modified implant, considering that the interface between a biomaterial surface and the living tissue plays an important role for this interaction. The production of reduced TiO2 nanotubes (RNT) with lower band gap is optimized and their performance is compared with those of simple TiO2 nanotubes (NT). The more conductive surfaces provided by the presence of RNT on Ti, allow a facile deposition of silk fibroin (SF) film using the electrochemical deposition method. This hybrid film is then functionalized with ZnO nanoparticles, to improve the antibacterial effect of the coating. The modified Ti surface is evaluated in terms of surface chemistry, morphology and roughness, wettability, surface energy, surface charge and antibacterial properties. Surface analysis such as SEM, AFM, FTIR and contact angle measurements were performed to obtain topographical features and wettability. FT‐IR analysis confirms that SF was effectively attached to TiO2 nanotubes surfaces. The electrochemical deposition of SF and SF‐ZnO reduced the interior diameter of nanotubes from ~85 nm to approx. 50–60 nm. All modified surfaces have a hydrophilic character.
Structured Cerium–Manganese Catalysts Supported on Nickel Foam for Toluene Oxidation by Electric Internal Heating
Authors: Zhang Bo Yu , Wu Xiao‐Kuan , Gao Jun An , Zhao Hong 
Published: October 2023

AbstractStructured catalysts are widely used in catalytic oxidation of gaseous pollutants, hot catalysis is usually needed to assist the reaction in the catalytic process. Herein, a Ce‐modified manganese oxide octahedral molecular sieves (Ce‐OMS‐2) structured catalyst supported on foam nickel was prepared through impregnation process. A systematically quantitative testing on the toluene catalytic oxidation effectiveness of this structured catalyst was conducted through catalyst evaluation device, combining a series of characterization methods, such as XRD and SEM, the structure‐activity relationship was established. Assisted with electric internal heating and ozone oxidation environments, this structured catalyst exhibits excellent catalytic oxidation performance for oxidative decomposition of toluene even under high humidity conditions. The results showed that the ozone‐coupled structured nickel foam catalyst increased the decomposition efficiency of toluene from 25 % (without catalyst and heating) to 55 % (with catalyst and without heating) and the electric internal heating can significantly improve the reactivity and moisture resistance of the structured nickel‐foam catalyst, at 90 % RH and 40000 h−1, 50000 ppb O3 and 40 mg/m3 toluene was maintained 100 % catalytic efficiency. The high‐efficiency non‐precious metal‐based electrothermal catalyst prepared herein is expected to have certain enlightenment for the purification of VOCs.
Two New Polar Antimony(III) Tartrates with Unusual Structural Building Units
Authors: Císařová Ivana , Becker Petra , Matulková Irena , Němec Ivan , Němec Petr , Bohatý Ladislav 
Published: October 2023

AbstractLarge single crystals of polar tetragonal thallium antimony(III) tartrate dihydrate, Tl2[Sb2((+)C4H2O6)2]·2H2O, are grown. The crystal structure (s.g. P41), which contains the binuclear complex group [Sb2(C4H2O6)2]2− and dimer groups [Tl2O8(H2O)2], is given, together with vibrational spectra, refractive indices and their dispersion, and an analysis of SHG phase matching possibility and SHG powder measurements. The crystals allow type I phase matching for laser wavelengths ≥ 1.0103 µm. In addition, a new monoclinic (s.g. C2) antimony(III) tartrate of composition Mg[Sb3((+)C4H2O6)2((+)C4H4O6)((+)C4H5O6)]·11H2O and its crystal structure, which contains a novel type of antimony tartrate complex group [Sb3(C4H2O6)2(C4H4O6)(C4H5O6)], is presented.
The New Gatifloxacin‐p‐Coumaric Acid Cocrystalline Form for Enhanced In Vitro Pharmaceutical Properties While Improving Oral Bioavailability and Antibacterial Activity
Authors: Ma Kai‐Jie , Li Ze , Bai Run‐Chao , Zhang Hai‐Juan , Zhang Chun , Liu Lu 
Published: October 2023

AbstractA molecular salification strategy of double majorization and synergistic improvement efficacy has been submitted, aiming at getting utmost out of the advantages of phenolic acid nutrient p‐coumaric acid (CMA) to improve the pharmaceutical properties of antibacterial agent gatifloxacin (GAT). The present strategy applies the saltforming capacity of CMA interacting with GAT to self‐assemble a new molecular salt, thereby improving the in vitro physicochemical performances of GAT and further perfecting its in vivo pharmacokinetics, as well as enhancing the antibacterial effectiveness of GAT. Guided by this strategy, the novel GAT‐phenolic acid nutrient molecular salt, named GAT‐CMA, is directionally prepared with its precise structure analyzed by single crystal X‐ray diffraction. The results show that proton transfer occurs between the piperazine N of GAT and the carboxyl group of CMA, thus altering the intermolecular interaction mode of GAT itself, breaking the relatively stable zwitterionic state, displaying a circular stacking structure dominated by [GAT+‐CMA−], which is conducive to the improvement of GAT's physicochemical properties. Interestingly, the enhanced properties in vitro effectively translate into pharmacokinetic merits in vivo, showing improved bioavailability. More importantly, due to the synergistic antibacterial effect of GAT and CMA, the antibacterial ability of molecular salt has also been effectively enhanced.
Characterization of agronomic traits and genomic diversity in a newly assembled radish core collection
Authors: Huh Sun Mi , Cho Ara , Yim Bomi , Kim Jiin , Jeong Jin Gyu , Jang Hoyeol , Mun Jeong‐Hwan , Yu Hee‐Ju 
Published: October 2023

AbstractCrop breeding programs are reliant on the genetic diversity of varieties and germplasm collections. Raphanus sativus L. is a root crop species of the Brassicaceae family that accounts for ∼2% of global vegetable production. We recently reported the assembly of a new radish core collection consisting of 125 accessions obtained from worldwide germplasm banks. To develop a comprehensive plant resource for radish research and breeding, we characterized the agronomic traits of 83 accessions and analyzed their genome‐wide DNA variations along with 17 previously analyzed accessions. A total of 14 agronomically important root, leaf, and flower phenotypic traits were examined according to the guidelines of the International Union for the Protection of New Plant Varieties. Chemical diversity in radish roots was investigated by measuring their sugar, glucosinolate, and anthocyanin contents. Through high‐depth whole‐genome resequencing of 100 accessions and multi‐sample genotyping analysis using the Rs2.0 genome assembly as a reference, we identified a total of 796,294 homozygous high‐quality single‐nucleotide polymorphisms. Genetic structural analysis using a neighbor‐joining algorithm and multi‐dimensional scaling analysis of the variations were applied to classify the accessions into three major groups, including 37 and 55 accessions of European and Asian cultivated radishes, respectively, and eight wild radish accessions. For each accession, the mitochondria‐encoded Ogura cytoplasmic male‐sterility determinant orf138 and nuclear fertility restorer PPR‐B genes were reconstructed by reference‐guided assembly. It is anticipated that these genetic diversity and agronomic properties of the radish core collection will facilitate breeding programs to develop new radish cultivars with desirable profiles.
Simulation‐based decision‐making and implementation of tools in hybrid crop breeding pipelines
Authors: Peixoto Marco Antônio , Coelho Igor Ferreira , Leach Kristen A. , Bhering Leonardo L. , Resende Márcio F. R. 
Published: October 2023

AbstractNew technologies have been developed over the last few years aiming to support breeding pipeline optimization for long‐term genetic gains. However, the implementation of these new tools and their impact on any breeding program's budget are not well studied. Here, we compare multiple breeding pipeline strategies accounting for genomic selection and high‐throughput phenotyping (HTP) by means of hybrid gain and cost‐effectiveness. We simulated a hybrid crop breeding program through coalescent theory. We compared two strategies for parental updates and four breeding pipelines: conventional breeding pipeline; conventional breeding pipeline with HTP; conventional breeding pipeline with genomic selection; conventional breeding pipeline with genomic selection and HTP. All analyses were implemented under three different levels of genotype‐by‐environment interaction (G×E) and two trait heritabilities (0.3 and 0.7). Overall, the results show that scenarios with early parental selection perform better than the others. In addition, the implementation of HTP delivered the highest hybrid gain in the long‐term, whereas the implementation of genomic selection seems to be more cost‐effective. We suggest, considering breeding programs with complex trait inheritance and accounting for higher levels of G×E, investing in breeding pipelines accounting for genomic selection as a strategy to create and maintain long‐term hybrid gain. Moreover, considering an unconstrained budget, the investment in both, genomic selection and HTP, represents the best strategy. Hence, these results provide strategies that may aid breeders in optimizing self‐pollination breeding programs.