bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAS BACTERIAS TAMBIÉN SON ÚTILES. ¿QUÉ ES UNA CELDA DE COMBUSTIBLE MICROBIANA?
Authors: Montiel Ana M. , Méndez Erika , Rodríguez-Valadez Francisco J. , González-Fuentes Miguel A. 
Published: February 2024

Las bacterias son microorganismos que habitan en todos los ecosistemas del planeta y las encontramos con tres morfologías, las circulares que son llamadas cocos, las alargadas como bastones llamadas bacilos y las espirales llamadas espiroquetas. Aunque algunas de ellas pueden ser perjudiciales para los seres humanos, provocándo enfermedades (bacterias patogénicas), también hay bacterias “buenas” que ayudan a los seres humanos y aunque parezca increíble, existen muchas bacterias de éste tipo. En el presente artículo, hablaremos de una tecnología ecológica que se apoya en un tipo de bacterias llamadas electrogénicas, donde se aprovecha el proceso de respiración de estas bacterias cuando descomponen la materia orgánica contenida en el agua residual producida por los humanos y se obtiene, de forma simultánea, energía eléctrica. Esta eco-tecnología se denomina Celda de Combustible Microbiana, y aunque fue estudiada por primera vez en 1911, sigue ofreciendo un amplio campo para el desarrollo de la investigación científica, ya que el desarrollo de una tecnología que logre el tratamiento del agua residual, y con ello la obtención de energía, se considera imperativo en el camino del desarrollo hacia una sociedad responsable con el medio ambiente.
تأثير تمرينات بوسائل مساعدة لتحسين بعض المتغيرات البيوميكانيكية للارسال بالتنس الارضي للطلاب
Authors: Assis  Teacher . Saba Laith Ismail  , Prof. Dr. Adel Odeh Al-Ghazi  
Published: February 2024

هناك مجموعة من الطلاب الذين يعانون من عدم تعلم المهارات بصورة كاملة او صحيحة وبالتالي نحتاج الى تمارين تصحيحة تساعد على تحسين تعلم الطلاب ولذلك ارتآى الباحثان الى استخدام تمارين تصحيحة بوسائل مساعدة حديثة تساهم في تصحيح وتحسين مستوى الطلاب المهاري للتنس الارضي في كلية التربية البدنية وعلوم الرياضة / جامعة العين الاهلية / المرحلة الثالثة .إعداد تمرينات تصحيحة بوسائل حديثة لتصحيح الاخطاء لمهارتي الضربة الامامية والخلفية بالتنس الأرضي لطلاب كلية التربية البدنية جامعة العين الأهلية المستوى الثالث للسنة الدارسية (2021-2022)، وتمثل مجتمع البحث بطلاب كلية التربية البدنية وعلوم الرياضة جامعة العين وتم تحديد مجتمع البحث بالطريقة العمدية لإجراء البحث عليهم اما عينة البحث فقد تم اختيارها بالطريقة العشوائية القرعة بشرط توافر متطلبات البحث فيهم من تأخر في تعلم المهارات بصورة جيدة إذ تم تحديد ذلك عن طريق الملاحظة وسؤال مدرس المادة، وبلغ عددهم( 23) طالباً بعمر (22-23) سنة ، وتم استبدال لاعبين اثنين ممن لم يلتزموا بالحضور للاختبار القبلي ، وبذلك بلغت النسبة المئوية لعينة البحث (43.478%)، واستنتج الباحثان إن التمرينات التصحيحة بالوسائل الحديثة قد حسنت من مستوى الأداء المهاري لمهارتي الضربة الأمامية والخلفية وعمقها بوقت قصير،
بعض القدرات الحس حركية وعلاقتها بقدرة التوازن الحركي لدى لاعبات المبتدئات بالجمناستك
Authors: م.د. ميس علاء الدين  
Published: February 2024

تم التطرق الى لعبة الجمناستك وقدرة التوازن أحد الأساسيات في عالم الجمناستك، إذ تمكِّن اللاعبة من الحفاظ على استقرار جسدها أثناء أداء التمارين المختلفة، سواء كانت تلك التمارين على الأرض أو على الأدوات، ويجب أن تكون اللاعبة قادرة على الاعتماد على نظام حسّي دقيق يمكِّنها من استشعار وتصحيح حركاتها بشكل فوري وفعال وبرزت مشكلة البحث خلال التساؤل ماهي العلاقة بين القدرات الحس حركية مع قدرة التوازن الحركي لدى لاعبات الجمناستك المبتدئات؟ واستخدمت الباحثة المنهج الوصفي على عينة من(8) لاعبات مبتدئات وحددت الباحثة الاختبارات الخاصة بالقدرات الحس حركية ( اختبار الاحساس بالمسافة واختبار الاحساس بالقوة واختبار الاحساس بالزمن فضلا عن اختبار للتوازن الثابت والمتحرك واجريت التجربة الرئيسة وبعد معالجة البيانات استنتجت الباحثة ان هناك علاقة بين بعض القدرات الحس حركية وعلاقتها بقدرة التوازن الحركي لدى لاعبات رياضة الجمناستك المبتدئات واوصت الباحثة استخدام القياسات الحس حركية التي اسفرت عنها هذه الدراسة بوصفها اسلوبا اوليا لاختيار اللاعبات المبتدئات.
القيمة التنبؤية لمستوى مهارة التهديف بدلالة بعض القدرات البدنية كمؤشر لانتقاء لاعبات كرة القدم للصالات للنساء
Authors: م.د. دعاء عائد شمخي الطائي  
Published: February 2024

يستخدم التنبؤ في مجال كرة القدم للصالات للكشف عن مستقبل اللاعبات من خلال عملية الانتقاء ليستمروا بممارسة هذه الرياضة الذي يتلاءم مع إمكانياتهم وقدراتهم، وتقع هذه العملية على مسؤولية المدرب المختص والاختبارات الخاصة التي يجريها في عملية الانتقاء ومشكلة البحث تتركز في نسبة مساهمة كل متغير من القدرات البدنية في مهارة التهديف لدى اللاعبات للتنبئو بأداء المهارة وكذلك للتعرف على الاحتياجات الاساسية من اجل انتقاء الحقائق والمفاهيم و تحقيق الانجازات العالية في لعبة كرة الصالات وهدف البحث للتعرف على نسبة مساهمة بعض القدرات البدنية بالمستوى المهاري لمهارة التهديف لدى لاعبات كرة القدم للصالات على عينة التجربة الرئيسة والبالغ عددهنُ(22) لاعبة واستخدمت المنهج الوصفي وتحديد استخدام المنهج الوصفي وحددت مهارة دقة التهديف والقدرات البدنية (القوة الانفجارية للساقين والسرعة الانتقالية وتحمل السرعة والرشاقة واجرت الباحثة تجربة استطلاعية وتجربة رئيسة استخدمت الباحثة الؤسائل الإحصائية واستنتجت الباحثة أسهم متغير (الرشاقة الحركية )، بأعلى نسبة مساهمة بدقة التهديف في كرة الصالات للنساء واوصت بضرورة الاهتمام بنسب الاسهام التي اظهرتها الدراسة لقدرة الرشاقة الحركية في عملية الانتقاء.
Kualitas Pelayanan Publik (Studi Kasus:Pelayanan Tera/Tera Ulang Di Kota Dumai)
Authors: Tobing Hildawati 
Published: February 2024

Pelayanan Tera/ Tera Ulang di Kota Dumai merupakan wewenang Dinas Perdagangan Kota Dumai dibawah tanggungjawab Bidang Kemetrologian khususnya Seksi pelayanan Tera dan Tera Ulang. Berdasarkan observasi ditemukan permasalahan yaitu kurangnya jumlah penera, alat uji yang kurang memadai, kurangnya akses informasi dan area pelayanan masih terbatas. Tujuan peneitian adalah untuk mengetahui kualitas pelayanan tera/tera ulang pada Dinas Perdagangan Kota Dumai. Teori yang digunakan adalah menurut Dabholkar (1996) dalam Al Idrus (2019: 2) yang menjelaskan bahwa tolak ukur kualitas pelayanan yaitu: physical aspect (aspek fisik), reliability (keandalan), personal interaction (interaksi personal), problem solving (pemecahan masalah) dan policy (kebijakan). Responden penelitian adalah pegawai Dinas Perdagangan dan Pelaku Usaha. Jumlah sampel sebanyak 119 orang. Teknik pengumpulan data mnggunakan observasi, angket dan wawancara. Metode analisis data yang digunakan adalah mixed method. Hasil analisis menunjukkan bahwa Kualitas Pelayanan Tera/ Tera Ulang Pada Dinas Perdagangan Kota Dumai dikategorikan Baik karena skor yang diperoleh yaitu 8225 berada pada rentang 8.095 – 9.999.
Faktor-faktor yang Mempengaruhi Keberhasilan Implementasi Penggunaan Presensi Online
Authors: PRAYOGA DICKY PRAYOGA , Nalien Elvira Mulya 
Published: February 2024

Peraturan Pemerintah Nomor 94 Tahun 2021 tentang Disiplin Pegawai Negeri Sipil menegaskan bahwa Pegawai Negeri Sipil (PNS) diharapkan sanggup menaati kewajiban dan menghindari larangan yang ditentukan dalam peraturan perundang-undangan. Salah satunya dapat dilihat dari kedisiplinan untuk waktu kedatangan dan kepulangannya sesuai dengan jam kerja yang telah ditentukan. Oleh sebab itu Biro Administrasi Pimpinan sebagai salah satu instansi pengambil kebijakan bermaksud mendorong PNS agar lebih berdisiplin melalui aplikasi presensi online karena telah memperhatikan beberapa bentuk ketidaktertiban presensi yang dilakukan secara manual. Dengan demikian penulis bermaksud untuk memperhatikan dan kemudian mendeskripsikan faktor-faktor yang mempengaruhi keberhasilan implementasi presensi online dimaksud. Penulis menggunakan Pendekatan Kualitatif, Metode Deksriptif serta teknik pengumpulan data berupa Wawancara Semi Terstruktur, Observasi Partisipasi Pasif dan dokumentasi. Adapun teknik penetuan informan adalah Purpossive Sampling yaitu Kepala Biro sebagai pengambil kebijakan dan operator sebagai pelaksana teknis presensi online pada Biro Administrasi Pimpinan Sekretariat Aceh. Sedangkan teknik analisa data merujuk Miles dan Huberman yaitu reduksi data, penyajian data dan penarikan kesimpulan. Menurut O’Brien dan Marakas ada beberapa faktor yang mempengaruhi keberhasilan implementasi suatu sistem informasi yaitu adanya dukungan dari manajemen eksekutif, keterlibatan pemakai akhir (end user), pemakaian kebutuhan yang jelas, perencanaan yang jelas dan harapan yang nyata. Berdasarkan hasil Penulisan, penggunaan presensi online pada Biro Administrasi Pimpinan Sekretariat Aceh berjalan dengan baik dilihat dari baiknya seluruh dimensi dimaksud. Seluruh pegawai negeri sipil yang bekerja pada instansi tersebut telah memanfaatkan aplikasi presensi online sehingga dapat mengkoordinir kedisiplinan agar memaksimalkan jam kerja demi kinerja yang lebih baik.
Pre-operative immune cell numbers and ratios are associated with peri-operative adverse outcomes in transfused patients
Authors: Roets Michelle , Sturgess David J. , Chen Ching-Yu , Punnasseril Jaisil E. J. , Jones Lee , van Zundert Andre A. , Dean Melinda M. 
Published: February 2024

Background and objectivesTransfusion-related immune modulation (TRIM) and associated adverse outcomes during major surgery are increasingly important to patients and health services internationally. A panel of pre-operative blood tests is an essential part of the pre-operative anaesthetic assessment. This panel of blood tests commonly considers numbers of immune cells (i.e., lymphocytes, monocytes, and neutrophils and cell ratios) that may be used as biomarkers to evaluate and potentially predict post-operative adverse outcomes.DesignThis retrospective data collection from eight hospital databases, within the Royal Brisbane and Women's Hospital, considered only patients who received blood transfusion during surgery (2016–2018) (n = 2,121). The association between pre-operative immune cell numbers and ratios and adverse outcomes were assessed. Adverse outcomes were coded using the International Classification of Diseases-10 (ICD-10) coding which specifically considered transfusion-related immune modulation. Results were adjusted for confounding factors.ResultsAfter adjustment, decreased pre-operative lymphocyte numbers and increased neutrophil/lymphocyte ratio (NLR) were associated with increased odds of developing infection; decreased NLR with decreased odds of developing adverse renal outcomes; and decreased lymphocyte numbers with decreased odds of developing adverse cardiovascular outcomes. Monocyte numbers, neutrophil numbers, and the lymphocyte/monocyte ratio (LMR) were not associated with increased adverse outcomes after adjustment.ConclusionPre-operative lymphocyte numbers and NLR are associated with adverse outcomes during peri-operative transfusion. Future assessment of peri-operative immune modulation should include the assessment of immune cell function and numbers.
Efficacy and safety of tongxinluo capsule for angina pectoris of coronary heart disease: an overview of systematic reviews and meta-analysis
Authors: Li Liuying , Feng Peimin , Zhou Wenhua , Luo Biao , Deng Lvyu , Gan Daohui , Wu Xiaohan , Zhu Fengya , Zhou Xia 
Published: February 2024

BackgroundTongxinluo capsule (TXLC) is a common drug for treating angina pectoris of coronary heart disease (CHD). In recent years, many systematic reviews (SRs) and meta-analyses (MAs) have reported the efficacy and safety of TXLC for improving angina symptoms in patients with CHD. We aimed to comprehensively evaluate the existing SRs and MAs of TXLC in treating angina pectoris of CHD, summarize the evidence quality, and provide scientific evidence and recommendations.MethodsWe searched seven databases for relevant SRs/MAs published up to 1 June 2023. Two reviewers independently completed the literature retrieval, screening, and data extraction. We used A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) to evaluate the methodological quality, the Risk of Bias in Systematic Reviews (ROBIS) to assess the risk of bias, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) to determine the strength of the evidence. RevMan 5.3 was used to synthesize data.ResultsWe identified 15 SRs/MAs, including 329 RCTs and 33,417 patients. According to the evaluation results of AMSTAR-2, only one SR was of high methodological quality, the others were very low. ROBIS assessment showed that one SR (6.67%) had a low risk, 3 SRs (20%) had an unclear risk, and 11 SRs (73.33%) had a high risk. We assessed 42 outcomes by the GRADE, 10 (23.81%) for moderate-quality evidence, 17 (40.48%) for low-quality evidence, and 15 (35.71%) for very-low-quality evidence. Mate-analysis showed that TXLC combined with conventional western medications improved electrocardiogram efficacy (RR = 1.38, 95% CI: 1.23–1.43, P &lt; 0.001) and angina efficacy (OR = 3.58, 95% CI: 3.02–4.24, P &lt; 0.001), reduced angina attack frequency (SMD = −0.54, 95% CI: −0.64 to −0.44, P &lt; 0.001) and angina duration (SMD = −0.42, 95% CI: −0.57 to −0.28, P &lt; 0.001), with general heterogeneity. The pooled results showed that TXLC appears to have some efficacy in improving cardiac function and relieving angina symptoms, but there is limited evidence that it improves cardiovascular event rates, hemorheology, lipids, or hs-CRP. In the assessment of drug safety, TXLC was associated with different degrees of adverse drug reactions.ConclusionBased on the evidence, TXLC may be effective as an adjuvant treatment for angina pectoris of CHD. However, the quality of the evidence is low, and the drug's safety must be carefully interpreted. In future studies, high-quality randomized controlled trials are needed to confirm the effectiveness and safety of TXLC.Systematic Review Registrationhttp://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022365372).
People living with HIV display increased anti-apolipoprotein A1 auto-antibodies, inflammation, and kynurenine metabolites: a case–control study
Authors: Frias Miguel A. , Pagano Sabrina , Bararpour Nasim , Sidibé Jonathan , Kamau Festus , Fétaud-Lapierre Vanessa , Hudson Peter , Thomas Aurélien , Lecour Sandrine , Strijdom Hans , Vuilleumier Nicolas 
Published: February 2024

ObjectiveThis study aimed to study the relationship between auto-antibodies against apolipoprotein A1 (anti-apoA1 IgG), human immunodeficiency virus (HIV) infection, anti-retroviral therapy (ART), and the tryptophan pathways in HIV-related cardiovascular disease.DesignThis case–control study conducted in South Africa consisted of control volunteers (n = 50), people living with HIV (PLWH) on ART (n = 50), and untreated PLWH (n = 44). Cardiovascular risk scores were determined, vascular measures were performed, and an extensive biochemical characterisation (routine, metabolomic, and inflammatory systemic profiles) was performed.MethodsAnti-apoA1 IgG levels were assessed by an in-house ELISA. Inflammatory biomarkers were measured with the Meso Scale Discovery® platform, and kynurenine pathway metabolites were assessed using targeted metabolomic profiling conducted by liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS).ResultsCardiovascular risk scores and vascular measures exhibited similarities across the three groups, while important differences were observed in systemic inflammatory and tryptophan pathways. Anti-apoA1 IgG seropositivity rates were 15%, 40%, and 70% in control volunteers, PLWH ART-treated, and PLWH ART-naïve, respectively. Circulating anti-apoA1 IgG levels were significantly negatively associated with CD4+ cell counts and positively associated with viremia and pro-inflammatory biomarkers (IFNγ, TNFα, MIPα, ICAM-1, VCAM-1). While circulating anti-apoA1 IgG levels were associated with increased levels of kynurenine in both control volunteers and PLWH, the kynurenine/tryptophan ratio was significantly increased in PLWH ART-treated.ConclusionHIV infection increases the humoral response against apoA1, which is associated with established HIV severity criteria and kynurenine pathway activation.
Burden of psoriasis in young adults worldwide from the global burden of disease study 2019
Authors: Zhang Yuanchen , Dong Shuai , Ma Yuan , Mou Yan 
Published: February 2024

BackgroundTo determine the global burden of psoriasis in young adults, i.e., those aged 15–49, from 1990 to 2019 and predict trends in this burden for 2020 to 2030MethodsAge-standardized disease burden indicators and their estimated annual percentage changes were assessed and used to compare the estimated burden between regions. In addition, generalized additive models were used to predict the burden in this population from 2020 to 2030.ResultsFrom 1990 to 2019, the overall burden of psoriasis in young adults worldwide trended downward, as the age-standardized incidence rate and the age-standardized disability-adjusted life year rate decreased. From 1990 to 2019, there were gender differences in the burden of psoriasis between regions with different Socio-demographic index. Specifically, there was a smaller increase in the burden in young men than in young women in middle- and low–middle-Socio-demographic index areas. In 2019, Western Europe, Australasia, and Southern Latin America had the highest age-standardized incidence rate of psoriasis in young adults, whereas age-standardized disability-adjusted life year rates of psoriasis in young adults were highest in high-income North America. In 2019, the psoriasis burden in young adults was the highest in high-Socio-demographic index areas and the lowest in low-Socio-demographic index regions. We predict that from 2020 to 2030, the incidence rate and disability-adjusted life year rate of psoriasis in all age groups of young adults will continue to decline, but the burden in those aged 30–39 will increase.ConclusionFrom 1990 to 2019, the overall burden of psoriasis in each age group trended downward in this period. We predict that from 2020 to 2030, the burden of psoriasis in those aged 30–39 will increase.
Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches
Authors: Niarakis Anna , Ostaszewski Marek , Mazein Alexander , Kuperstein Inna , Kutmon Martina , Gillespie Marc E. , Funahashi Akira , Acencio Marcio Luis , Hemedan Ahmed , Aichem Michael , Klein Karsten , Czauderna Tobias , Burtscher Felicia , Yamada Takahiro G. , Hiki Yusuke , Hiroi Noriko F. , Hu Finterly , Pham Nhung , Ehrhart Friederike , Willighagen Egon L. , Valdeolivas Alberto , Dugourd Aurelien , Messina Francesco , Esteban-Medina Marina , Peña-Chilet Maria , Rian Kinza , Soliman Sylvain , Aghamiri Sara Sadat , Puniya Bhanwar Lal , Naldi Aurélien , Helikar Tomáš , Singh Vidisha , Fernández Marco Fariñas , Bermudez Viviam , Tsirvouli Eirini , Montagud Arnau , Noël Vincent , Ponce-de-Leon Miguel , Maier Dieter , Bauch Angela , Gyori Benjamin M. , Bachman John A. , Luna Augustin , Piñero Janet , Furlong Laura I. , Balaur Irina , Rougny Adrien , Jarosz Yohan , Overall Rupert W. , Phair Robert , Perfetto Livia , Matthews Lisa , Rex Devasahayam Arokia Balaya , Orlic-Milacic Marija , Gomez Luis Cristobal Monraz , De Meulder Bertrand , Ravel Jean Marie , Jassal Bijay , Satagopam Venkata , Wu Guanming , Golebiewski Martin , Gawron Piotr , Calzone Laurence , Beckmann Jacques S. , Evelo Chris T. , D’Eustachio Peter , Schreiber Falk , Saez-Rodriguez Julio , Dopazo Joaquin , Kuiper Martin , Valencia Alfonso , Wolkenhauer Olaf , Kitano Hiroaki , Barillot Emmanuel , Auffray Charles , Balling Rudi , Schneider Reinhard ,   the COVID-19 Disease Map Community
Published: February 2024

IntroductionThe COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop interoperable bioinformatic pipelines for novel target identification and drug repurposing. MethodsExtensive community work allowed an impressive step forward in building interfaces between Systems Biology tools and platforms. Our framework can link biomolecules from omics data analysis and computational modelling to dysregulated pathways in a cell-, tissue- or patient-specific manner. Drug repurposing using text mining and AI-assisted analysis identified potential drugs, chemicals and microRNAs that could target the identified key factors.ResultsResults revealed drugs already tested for anti-COVID-19 efficacy, providing a mechanistic context for their mode of action, and drugs already in clinical trials for treating other diseases, never tested against COVID-19. DiscussionThe key advance is that the proposed framework is versatile and expandable, offering a significant upgrade in the arsenal for virus-host interactions and other complex pathologies.
Normalized circulating Tfh and Th17 associates with improvement in myasthenia gravis treated with ofatumumab
Authors: Song Xiaodong , He Yang , Huo Yang , Jiang Hong , Yu Yao , Sun Yue , Liu Zunjing , Zhang Zhaoxu 
Published: February 2024

ObjectiveTo assess the effect of B cell depletion therapy (BCDT) on circulating T follicular helper (cTfh) and circulating T helper 17 (cTh17) cells and its relation to clinical improvement in patients with myasthenia gravis (MG).Methods28 anti-AchR positive MG patients treated with ofatumumab and 28 healthy controls (HCs) were included. Frequencies of cTfh and cTh17 cells were monitored by flow cytometry at baseline and 4, and 12 weeks after the initial dose ofatumumab. Serum cytokines associated with cTfh and cTh17, including IL-6, IL-21, and IL-17, were also analyzed.ResultsThe frequency of cTfh and cTh17 significantly increased in MG patients compared with HCs. Additionally, elevated levels of both T-cell subsets correlated with MG severity. During the follow-up, cTfh and cTh17 return to normal after BCDT. Furthermore, the decrease in cTfh and cTh17 was associated with MG scores improvement over time. Notably, cTfh- and cTh17-related cytokines, including IL-6, IL-21, and IL-17, exhibited a marked decrease following ofatumumab therapy.ConclusionsAbnormal expansion of cTfh and cTh17 cells may be key features in the immunopathology of MG. Their levels returned to normal after BCDT, which was closely correlated with clinical amelioration. This result suggests that these two T-cell subsets may be targets for BCDT treatment of MG.