bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Therapeutic Effect of Natural Compounds on Osteoporosis
through Ferroptosis
Authors: Zhang Yong , Qu Zechao , Zhao Yiwei , Zhang Bo , Gong Yining , Wang Xiaohui , Gao Xiangcheng , Wang Dong , Yan Liang 
Published: October 2023

Abstract::
Ferroptosis is a newly discovered non-apoptotic cell death whose key is lipid
peroxidation. It has been reported that ferroptosis is involved in the occurrence and development
of tumors and nervous system and musculoskeletal diseases. Cellular ferroptosis
contributes to the imbalance of bone homeostasis and is involved in the development
of osteoporosis; however, the detailed mechanism of which is still unclear though
it may provide a new direction for anti-osteoporosis. The current drugs used in the treatment
of osteoporosis, such as bisphosphonates and teriparatide, have many side effects,
increasing people's search for natural compounds to treat osteoporosis. This review paper
briefly summarizes the current research regarding the mechanisms of ferroptosis and
natural anti-osteoporosis compounds targeting its pathway.
The Role of Tissue Factor In Signaling Pathways of Pathological
Conditions and Angiogenesis
Authors: Heidari Zahra , Naeimzadeh Yasaman , Fallahi Jafar , Savardashtaki Amir , Razban Vahid , Khajeh Sahar 
Published: October 2023

Abstract:
Tissue factor (TF) is an integral transmembrane protein associated with the
extrinsic coagulation pathway. TF gene expression is regulated in response to
inflammatory cytokines, bacterial lipopolysaccharides, and mechanical injuries. TF
activity may be affected by phosphorylation of its cytoplasmic domain and alternative
splicing. TF acts as the primary initiator of physiological hemostasis, which prevents
local bleeding at the injury site. However, aberrant expression of TF, accompanied by
the severity of diseases and infections under various pathological conditions, triggers
multiple signaling pathways that support thrombosis, angiogenesis, inflammation, and
metastasis. Protease-activated receptors (PARs) are central in the downstream
signaling pathways of TF. In this study, we have reviewed the TF signaling pathways in
different pathological conditions, such as wound injury, asthma, cardiovascular
diseases (CVDs), viral infections, cancer and pathological angiogenesis. Angiogenic
activities of TF are critical in the repair of wound injuries and aggressive behavior of
tumors, which are mainly performed by the actions of vascular endothelial growth
factor (VEGF) and hypoxia-inducible factor-1 (HIF1-α). Pro-inflammatory effects of TF
have been reported in asthma, CVDs and viral infections, including COVID-19, which
result in tissue hypertrophy, inflammation, and thrombosis. TF-FVII induces
angiogenesis via clotting-dependent and -independent mechanisms. Clottingdependent angiogenesis is induced via the generation of thrombin and cross-linked
fibrin network, which facilitate vessel infiltration and also act as a reservoir for
endothelial cells (ECs) growth factors. Expression of TF in tumor cells and ECs
triggers clotting-independent angiogenesis through induction of VEGF, urokinase-type
plasminogen activator (uPAR), early growth response 1 (EGR1), IL8, and cysteine-rich
angiogenic inducer 61 (Cyr61).
Technological Parameters of Microfiltration in the Production of Micellar
Casein Concentrate
Authors: Melnikova Elena I. , Stanislavskaya Ekaterina B. , Bogdanova Ekaterina V. 
Published: October 2023

Background::
There are many different factors that influence the process of microfiltration,
including membrane pore size, pressure, temperature, and membrane origin. Studying the
joint influence of technological parameters in order to justify rational modes of microfiltration is
relevant.

Objective::
This research aimed to define the rational technological parameters of microfiltration,
which allow to achieve the target parameters of retentate in the process of obtaining micellar casein
concentrate.

Methods::
Standard and modified methods and techniques have been used in the process of experimental
research. The mathematical processing was carried out by methods of mathematical statistics
according to several trials data at three stage sequence.

Results::
As a result of experimental investigations, the applicability of ceramic membranes for microfiltration
of skim milk has been shown. The rational pore size has been established as 0,1 μm.
To obtain the micellar casein concentrate, it is advisably to carry out the microfiltration of skim
milk to the mass fraction of dry solids in concentrate (13 ± 3) %, followed by two-phase diafiltration
with a double volume of reverse osmosis water. The rational operating conditions, allowing
to get the target value of protein fractions correlation, have been established, as described as follows:
input pressure as 0,2 – 0,3 MPa, and temperature as 10 – 15°С.

Conclusion::
The analysis of microfiltration concentrates and permeates composition of raw milk,
including vitamins and minerals content, showed both their high nutritional and biological value
and the viability of further processing into food ingredients, including the ingredients for the specialized
food products.
Hydrothermally Synthesized Boletus Brucella-derived Carbon Quantum Dots as a Fluorescent Probe for the Detection of Vitamin B2
Authors: Wan Qiang , Li Rong , Ren Meiping , Ke Gang 
Published: October 2023

Background:
In the paper, Boletus Brucella was used as carbon source material to
prepare carbon dots (CDs) by one-step hydrothermal method. The CDs had high quantum yield
and high photostability.

Methods:
A range of characterization studies were conducted on CDs, and the results showed
that the average particle size of CDs was 5 nm, emitting blue fluorescence. The optimal excitation
wavelength was 337 nm, and the emission wavelength was 440 nm.

Results:
Based on the static quenching, the fluorescence of CDs could be effectively quenched
by VB2. Therefore, a highly sensitive and selective fluorescent probe for detecting VB2 was
constructed. The CDs were successfully used to detect tablets, human blood, and urine.

Conclusion:
The recovery rate of VB2 was 97.55~99.45%, and the relative standard deviation
was 1.29~3.76 (n=3).
Organoids Research for Colorectal Cancer: Promising Approach for
Precision Medicine, their Applications and Future Perspectives
Authors: Singh Sonia , Ahuja Ashima , Ramankutty Raghavan , Ramaswamy Sarada 
Published: October 2023

Background:
Organoids are three-dimensional (3D) constructs designed to emulate the
complexity and functionality of organs in the body. Organoids have recently been used as powerful
instruments for modeling and investigating several diseases, including colorectal cancer. Colorectal
cancer is caused by altering colonic epithelial cells, which produce adenomas and carcinomas.

Objective:
The objective of present study was to investigate impact of organoids on colorectal cancer
and their therapeutic outcome in cancer research. Organoids can be grown from stem cells in
vitro, which closely resemble the structure and function of the organ they are derived from. They
have been used in a variety of research applications, including disease modeling, drug screening,
and personalized medicine. Organoids have allowed researchers to understand better the mechanisms
underlying colorectal cancer initiation, progression, and resistance to therapy.

Methods:
The literature review was surveyed, and keywords related to cancer management, organoids,
modelling, personized medicine, 3D structures were screened for colorectal cancer management
were screened in SCI-hub, SCOPUS, WOS, and ABC Journals.

Results:
The findings of studies suggested that organoids derived from patient tumors can recapitulate
the histopathology and genetic alterations of the original tumor, making them a valuable tool
for personalized medicine.

Conclusion:
Organoids have been used to develop high-throughput drug screening assays and investigate
the tumor microenvironment's contribution to colorectal cancer progression. In this review,
we summarize recent advances in the use of organoids to study colorectal cancer and discuss
their potential applications in the clinic.
Multivariate Statistical 2D QSAR Analysis of Indenoisoquinoline-based Topoisomerase-
I Inhibitors as Anti-lung Cancer Agents
Authors: Singh Supriya , Mangla Bharti , Javed Shamama , Kumar Pankaj , Ahsan Waquar 
Published: October 2023

Background:
Indenoisoquinoline-based compounds have shown promise as topoisomerase-I inhibitors,
presenting an attractive avenue for rational anticancer drug design. However, a detailed QSAR study on
these derivatives has not been performed till date.

Objective::
To study aimed to identify crucial molecular features and structural requirements for potent topoisomerase-
1 inhibition.

Methods:
A comprehensive two-dimensional (2D) QSAR analysis was performed on a series of 49 indenoisoquinoline
derivatives using TSAR3.3 software. A robust QSAR model based on a training set of 33 compounds
was developed achieving favorable statistical values: r2 = 0.790, r2CV = 0.722, f = 36.461, and s = 0.461. Validation
was conducted using a test set of nine compounds, confirming the predictive capability of the model (r2 =
0.624). Additionally, artificial neural network (ANN) analysis was employed to further validate the significance
of the derived descriptors.

Results:
The optimized QSAR model revealed the importance of specific descriptors, including molecular volume,
Verloop B2, and Weiner topological index, providing essential insights into effective topoisomerase-1 inhibition.
We also obtained a robust partial least-square (PLS) analysis model with high predictive ability (r2 =
0.788, r2CV = 0.743). The ANN results further reinforced the significance of the derived descriptors, with strong
r2 values for both the training set (r2 = 0.798) and the test set (r2 = 0.669).

Conclusion::
The present 2D QSAR analysis offered valuable molecular insights into indenoisoquinoline-based topoisomerase-
I inhibitors, supporting their potential as anti-lung cancer agents. These findings contribute to the rational design
of more effective derivatives, advancing the development of targeted therapies for lung cancer treatment.
Medicinal Herbs for the Treatment of Peptic Ulcers
Authors: Tiwari Divyansh , Alam Aftab , Dhoundiyal Shivang , Sharma Shaweta , Yadav Shikha 
Published: October 2023

:
Peptic ulcers are common gastrointestinal disorders characterized by the erosion of
the stomach lining, duodenum, or esophagus. Conventional treatments, such as proton pump inhibitors and antibiotics for Helicobacter pylori eradication, have been the mainstay of therapy.
However, the emergence of drug resistance and potential side effects have led to the exploration
of alternative and complementary approaches, including medicinal herbs. This comprehensive
review examines the potential use of medicinal herbs in the management of peptic ulcers. Ten
herbal remedies, including Liquorice, Slippery Elm, Marshmallow Root, Aloe Vera, Chamomile,
Ginger, Turmeric, Meadowsweet, Fenugreek, and Cabbage, are analyzed for their therapeutic
properties and scientific research findings. These herbs have demonstrated anti-inflammatory,
antimicrobial, and mucoprotective effects that may support ulcer healing and symptom relief.
Herbal formulations, such as teas, capsules, tablets, and extracts, offer convenient delivery
methods for patients seeking herbal remedies. However, safety considerations and potential
herb-drug interactions must be carefully monitored. Integrating herbal remedies with conventional treatments presents a comprehensive approach to peptic ulcer management. By combining
these therapies, patients may experience enhanced therapeutic outcomes and improved quality of
life. Dietary recommendations also play a crucial role, with the inclusion of soothing and beneficial foods, while avoiding trigger foods that may exacerbate symptoms. As the evidence base
grows, collaborative efforts between traditional herbal medicine practitioners and mainstream
medical professionals are vital to ensure safe and effective integration.
Feministiskt antikrigsmotstånd: Hur är det att som feminist kämpa mot Rysslands krig mot Ukraina?
Authors: Gradskova Yulia 
Published: October 2023

Feministiskt antikrig motstånd (FAM – feministskoe antivoennoe soprotivlenie) var en av de första nätverken som offentligt visade sin protest mot Rysslands anfall av Ukraina februari 24 2022. Nu, när kriget fortsätter mer än ett år, kan man med säkerhet säga att FAM inte bara fortsätter att vara en av dem mest konsekventa motståndare av kriget, men att den är också en av de mest radikala kritiker av de politiska och kulturella strukturer och värderingar som ligger till grund av ryska expansionismen.
This article is about the Feminist Anti-War Resistance (FAS), a network of activists within and outside Russia united in their support for LGBTQ+ rights and ready to resist the patriarchy and the Russian war on Ukraine. The article explores FAS’s ideas and tactics of activism.
UPAYA PENERAPAN EKOSIDA SEBAGAI KEJAHATAN LUAR BIASA DI INDONESIA
Authors: Muhammad Ali Ausath  
Published: October 2023

ABSTRAK
Lingkungan merupakan faktor penting dalam hidup manusia, namun sayangnya banyak perilaku manusia yang membawa kerusakan bagi lingkungannya sendiri. Bahkan beberapa kasus kerusakan yang disebabkan oleh manusia mengakibatkan musnahnya suatu ekosistem. Hal tersebut kemudian memunculkan istilah baru yaitu, ekosida. Ekosida merupakan kejahatan yang berdampak pada lingkungan dan bersifat masif, meluas, serta struktural yang jika dilakukan maka dapat merusak kualitas hidup manusia hingga menyebabkan kematian massal. Dampaknya yang luar biasa, ekosida kemudian diusung untuk menjadi salah satu jenis kejahatan luar biasa (extraordinary crime). Tujuan dari tulisan ini untuk memberikan penjelasan tentang perkembangan ekosida sebagai kejahatan luar biasa di dunia internasional dan melihat bagaimana upaya penerapannya di Indonesia. Penerapan ini menjadi penting karena penerapan ekosida menjadi kejahatan luar biasa merupakan agenda penting untuk melestarikan lingkungan hidup karena melihat kenyataan bahwa lingkungan hidup di Indonesia kondisinya semakin memprihatinkan. Penelitian ini menggunakan metode yuridis normatif yang menekankan pada studi law in book. Penelitian ini kemudian menyimpulkan bahwa ekosida perlu lebih diperhatikan dampaknya oleh masyarakat dan perlu adanya pengaturan khusus tentang ekosida dan menjadikannya sebagai kejahatan luar biasa.
Kata kunci: Ekosida; Kejahatan Luar Biasa; Lingkungan.
ABSTRACT
The environment is an important factor in human life, but unfortunately many human behaviors bring damage to their own environment. Even some cases of damage caused by humans result in the destruction of an ecosystem. This then gave rise to a new term, namely, ecocide. Ecocide is a crime that has an impact on the environment and is massive, widespread, and structural in nature that, if carried out, can damage the quality of human life to cause mass death. The impact is extraordinary, ecocide is then carried to become one of the types of extraordinary crimes. The purpose of this paper is to provide an explanation of the development of ecocide as an extraordinary crime in the international world and see how efforts are implemented in Indonesia. This application is important because the application of ecocide to be an extraordinary crime is an important agenda to preserve the environment because it sees the fact that the environment in Indonesia is increasingly poor. This research uses normative juridical methods that emphasize law in book studies. This research then concluded that ecocide needs to be paid more attention to its impact by society and there needs to be a special regulation of ecocide and make it an extraordinary crime.
Keywords: Ecocide; Environmental; Extraordinary Crime.
KERJA SAMA INTERNASIONAL DALAM MENGATASI KEPUNAHAN FLORA FAUNA DIKAITKAN DENGAN DEKLARASI STOCKHOLM 1972
Authors: Syukur Amalia Nurfitria , Fautngiljanan Johrdan 
Published: October 2023

ABSTRAK
Peristiwa punahnya flora dan fauna yang marak terjadi belakangan ini, telah menunjukkan suatu ketimpangan antara pelaksanaan penegakan hukum dengan pengaturan yang ada, khususnya di dalam sistem hukum lingkungan internasional. Secara global, terdapat dua bentuk kerja sama yang dapat dilakukan untuk mengatasi kepunahan flora dan fauna, yaitu kerja sama melalui perjanjian internasional dan kerja sama melalui organisasi internasional. Dalam hal ini, terdapat prinsip-prinsip dasar dalam Deklarasi Stockholm yang mengatur terkait perlindungan flora dan fauna. Prinsip kedua dan prinsip keempat Deklarasi Stockholm merupakan landasan hukum pertama yang mengatur mengenai sustainable use. Penelitian ini secara khusus akan membahas prinsip dalam Deklarasi Stockholm sebagai dasar perlindungan terhadap flora dan fauna. Tujuan penelitian ini adalah menganalisis dan mengkaji instrumen-instrumen hukum lingkungan internasional terhadap perlindungan flora dan fauna. Metode yang digunakan dalam penelitian ini adalah deskriptif analisis dengan pendekatan normatif dengan data yang diperoleh dari penelitian kepustakaan. Hasil penelitian ini adalah prinsip kedua dan keempat Deklarasi Stockholm melahirkan kerjasama-kerjasama internasional melalui perjanjian internasional dan organisasi internasional, tetapi adanya kerjasama-kerjasama ini harus dibarengi dengan itikad baik dari masyarakat internasional.
ABSTRACT
The extinction of flora and fauna that is happening today has shown a disparity between implementation of law enforcement and the regulation, especially in international environmental law system. There are two forms of cooperation that can be carried out to overcome the extinction of flora and fauna namely cooperation through international agreements and cooperation through international organizations. In this case, there are basic principles in the Stockholm Declaration which regulates the protection of flora and fauna. The second and fourth principles of the Stockholm Declaration are the first legal basis which regulates about sustainable use. This study specifically discusses the principles in the Stockholm Declaration as the basis for the protection of flora and fauna. The purpose of this study is to analyze and examine international environmental law instruments for the protection of flora and fauna. The method used in this research is descriptive analysis with a normative approach, with data obtained from literature study. This study shows that the second and fourth principles of the Stockholm Declaration have resulted in several international cooperations through international agreements and international organizations, but the existence of such cooperation must be accompanied by good faith from the international community.
PERLINDUNGAN HUKUM TERHADAP PEMILIK HAK ATAS TANAH BELUM TERDAFTAR YANG DIRUGIKAN AKIBAT MALADMINISTRASI PERANGKAT PEMERINTAHAN DESA
Authors: Adzannya Basuki Siti Hatia , Pujiwati Yani , Zamil Yusuf Saeful 
Published: October 2023

ABSTRAK
Pemerintahan Desa berperan memberi pelayanan kepada masyarakat yang hendak mendaftarkan tanah untuk pertama kali dengan menyediakan bukti permulaan berupa salinan letter C. Penelitian ini mengkaji bagaimana perlindungan hukum bagi pemilik hak atas tanah belum terdaftar atas mal administrasi Pemerintah Desa, juga bagaimana tanggung jawab Pemerintah Desa dalam hal terjadi mal administrasi letter C sehingga menimbulkan kerugian bagi pemilik hak atas tanah belum terdaftar. Penelitian ini dilakukan dengan menggunakan metode pendekatan yuridis normatif. Spesifikasi penelitian bersifat deskriptif analitis, kemudian dianalisis secara kualitatif. Secara teoritis tidak ada perlindungan hukum bagi pemilik hak atas tanah belum terdaftar karena pada prinsipnya pendaftaran tanah yang diatur dalam perundang-undangan bertujuan untuk memberikan perlindungan hukum dan menciptakan kepastian hukum, namun pada praktiknya pemilik hak atas tanah yang merasa haknya terlanggar dapat mengajukan keberatan ataupun gugatan, dan Pemerintah Desa yang terbukti melakukan mal administrasi dapat dikenai sanksi jabatan yang ditetapkan oleh Bupati.
Kata kunci: Mal administrasi; Pemerintahan Desa; Pendaftaran Tanah.
ABSTRACT
The Village Government provides services to those who want to register land for the first time by providing initial evidence in the form of a copy of letter C. This study examines how legal protection for owners of land rights has not been registered for maladministration of village government apparatus, as well as how the responsibility of the village government in the event of maladministration letter C resulting in losses for owners of land rights that have not been registered. This research was conducted using a normative juridical approach. The research specifications are descriptive analytical, then qualitatively analyzed. Theoretically there is no legal protection for owners of unregistered land rights. However, in practice, land rights owners who feel their rights have been violated can file an objection or lawsuit, and the village government proven to have committed maladministration may be subject to office sanctions determined by the Regent.
Keywords: Maladministration; Village Government; Land Registration.
Penerapan internet of things pada smart parking system untuk kebutuhan pengembangan smart city
Authors: Koten George Reynaldi , Probodinanti Hesti , Tamba Johanes Daulat , Saputri Marshanda Krisnawi , Kwa Stelly Alison , Hadisantono  , Dewa Parama Kartika 
Published: October 2023

Perkembangan zaman membuat kemajuan teknologi semakin pesat sehingga membuat manusia tidak terlepas dengan teknologi. Internet of Things (IoT) merupakan salah satu penerapan teknologi untuk memenuhi kebutuhan manusia dengan pemanfaatan konektivitas internet. Kendaraan sebagai kebutuhan sekunder manusia membutuhkan tempat parkir yang dapat memberikan rasa aman dan nyaman. Penelitian ini bertujuan untuk mengatasi permasalahan pengguna dalam mencari tempat parkir dengan menciptakan smart parking system. Studi kasus dilakukan di sebuah mall. Penelitian diawali dengan identifikasi permasalahan, kemudian merancang solusi, pengumpulan data yang relevan, serta perancangan dan pengkodean sistem. Smart parking system yang dirancang menggunakan sensor light dependent resistor (LDR) serta kamera automatic number plate recognition (ANPR) dan lampu liquid-crystal display (LCD) sebagai alat yang dapat dengan mudah memberikan informasi yang kemudian ditransfer ke pengontrol. Kendaraan yang masuk ke dalam sistem harus teridentifikasi dengan memanfaatkan quick response (QR) Code. Melalui smart parking system, pengemudi akan mendapatkan kemudahan menemukan tempat parkir kosong dengan lokasi terdekat, metode pembayaran yang mudah, serta keamanan yang terjamin karena terhubung dengan aplikasi pengguna.
Application Failure Mode Effect Analysis for Risk Management in New Costumer Acceptance Project in Garment Industry with approaching Project Management Body of Knowledge
Authors: Rahmawati Diah , Redi A.A.N. Perwira 
Published: October 2023

Purpose: This research aims to identify risks at the time of fulfillment of the requirements set by the customer and determine their mitigation.

Method: In order to achieve the goal, researchers use the PMBOK approach that focuses on risk management by creating WBS and RBS. From the existing risks assessed using the FMEA method by conducting a survey to get the S, O and D values then calculating the RPN.

Result: the highest RPN value in this study is 330 at risk 5.2. The understanding of PIC system and procedures in making the system, based on the result of brainstorming is decided that the mitigation is recruiting employee who is experienced in applying BSCI and factory evaluation audits due to the unavailability of employees who will become PIC compliance.