bluuebunny/crossref_metadata_2025_split huggingface dataset:
Études de durabilité de la semi-intensification de la production laitière dans le rayon de collecte de la Laiterie du Berger
Authors: Wade Daouda , Diaw Idrissa , Diaw Mamadou Tandiang , Cesaro Jean-Daniel , Dieng Abdoulaye 
Published: January 2025

Contexte : Au Sénégal, le système semi-intensif est de plus en plus mis en exergue pour accroitre la production laitière. Il s’agit d’un système de production encadré qui vise l’amélioration du système traditionnel par le biais de l’alimentation, la santé et la génétique. Cette semi-intensification se caractérise par une promotion de la stabulation avec l’installation de mini-fermes composées d’un noyau de 4 vaches de races maures ou métissées. Objectif : L’objectif de ce travail est d’évaluer la durabilité de la semi-intensification de la production laitière dans le contexte sénégalais. Méthodes : Dans un premier temps, une enquête auprès de 25 mini-fermes installées en 2019 a été conduite dans le rayon de collecte d’une laiterie à Richard-Toll au Sénégal. La durabilité de ces exploitations a été évaluée à l’aide de la méthode des Indicateurs de Durabilité des Exploitations Agricoles (IDEA4) adaptée à la réalité sénégalaise. Elle permet une double lecture : la première lecture selon les dimensions agroécologique, socio-territoriale et économique ; la seconde lecture selon les propriétés d’autonomie, de robustesse, de capacité productive et reproductive, d’ancrage territorial et de responsabilité globale. Résultats : Les résultats qui découlent de cette étude montrent que la durabilité de ces mini-fermes est limitée par la dimension agroécologique qui affiche une moyenne de 53/100. En revanche, les dimensions socio-territoriale et économique affichent respectivement des scores moyens de 59/100 et 69/100. Pour les propriétés « Capacité productive et reproductive de biens services » et « Responsabilité globale », les mini-fermes présentent des avantages considérables. En revanche, pour les propriétés « Ancrage territorial », « Autonomie » et « Robustesse », des améliorations sont à envisager. Conclusions : La sensibilisation dans les démarches environnementales, la diversification des produits, la mutualisation du travail ainsi que la contribution de revenus issus d’autres activités permettraient d’améliorer la durabilité des exploitations. De plus, ces mini-fermes doivent travailler sur l’autonomie pour les intrants, la robustesse pour faire face aux imprévus et l’ancrage territorial c’est-à-dire leur capacité à contribuer à un processus de co-production et de valorisation de ressources territoriales.
Enhanced Antibiotic Release and Mechanical Strength in UHMWPE Antibiotic Blends
Authors: Asik Mehmet D. , Walsh-Rock Eileen , Inverardi Nicoletta , Nepple Cecilia , Zhao Timothy , Sekar Amita , Kannambadi Devika Dutta , Ferreira Matheus , Wannomae Keith K. , Oral Ebru , Muratoglu Orhun K. 
Published: January 2025

Background:
Periprosthetic joint infections (PJIs) are a major complication of total joint replacement surgeries. This study investigated the enhancement of mechanical properties and antibiotic release in ultra-high molecular weight polyethylene (UHMWPE) through the encapsulation of submicron gentamicin sulfate (GS) particles, addressing the critical need for improved implant materials in orthopaedic surgery, particularly in managing PJIs.

Methods:
The present study involved embedding submicron GS particles into UHMWPE flakes at concentrations of 2% to 10% by weight. These particles were prepared and blended with UHMWPE flakes using a dual asymmetric centrifugal mixer, and the blends were consolidated. The present study compared the mechanical properties and antibiotic release rate of UHMWPE containing submicron, medium (as-received), and large (resolidified) GS particles.

Results:
UHMWPE samples with submicron GS particles exhibited superior mechanical properties, including higher ultimate tensile and Izod impact strengths, compared with samples with larger particles. Additionally, the submicron GS UHMWPE blends demonstrated a markedly higher and more sustained antibiotic release rate.

Conclusions:
This study highlights the potential of incorporating submicron GS particles into UHMWPE to drastically improve the feasibility of using these therapeutic and functional spacer implants in expanded indications.

Clinical Relevance:
By offering improved mechanical strength and effective, prolonged antibiotic release, this innovative material could be used as a spacer implant to reduce the considerably high morbidity and mortality associated with PJIs. This material has the potential to prevent PJIs not only in high-risk revision cases but also in primary total joint arthroplasty procedures.
Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling
Authors: Palacios Karen Diaz , Navajas Pilar López , Martín Bárbara Rodrigo , Luque-Ortega Juan R. , Echarri Asier , Lietha Daniel 
Published: January 2025

Abstract

Focal Adhesion Kinase (FAK) is a key signaling molecule in focal adhesions (FAs) orchestrating the formation, maturation and turnover of the FA complex. A controlled FA lifecycle is essential for various cellular processes requiring mesenchymal cell migration and is harnessed by advanced cancers to initiate cancer invasion and metastasis. The mechanical force for migration is transmitted from actin stress fibers to FAs via specialized force transduction components in FAs. These forces are known to activate FA signaling, suggesting a communication between FA force transduction and FA signaling components, yet how this occurs mechanistically is unknown. Here we demonstrate that paxillin can act as an adaptor protein to connect FAK with the force transduction component vinculin. Our data show that this connection forms inefficient in the basal state but suggest Y925 phosphorylation in FAK as a key mechanism for optimal formation of the FAK:paxillin:vinculin linkage. This is achieved by switching binding of the paxillin LD2 motif from FAK to vinculin while keeping paxillin LD4 tethered to FAK. We further provide the first high-resolution crystal structure of LD2 bound to the vinculin tail domain, which importantly shows that vinculin can simultaneously link to actin. This therefore ensures an intact force transduction role of vinculin while tethered via paxillin to the signaling apparatus in FAs. With this data, all interactions of the force transmitting tether to FAK are structurally defined and we provide an atomic model for FAK force activation. In summary, we propose a phospho-regulated connection between signaling and force transduction components in FAs allowing for force induced activation of FA signaling.
Anxiety, Depression, Fatique and Necroinflammatory Activity in Chronic Hepatitis B Patients: A Cross-sectional Study
Authors: Sezak Nurbanu , Korkmaz Ozge Eren , Arikan Burcu Acikalin , Kilic Osman Hasan Tahsin , Soydar Pelin 
Published: January 2025

Abstract

Background
Patients with chronic Hepatitis B (CHB) are more likely to experience mental health issues, which can become worse by liver fibrosis and inflammation. This study aimed to investigate the association of CHB-related necroinflammation and fibrosis on these psychiatric symptoms.
Methods
A cross-sectional analysis was conducted on 200 CHB patients. The degree of liver inflammation and fibrosis was evaluated using non-invasive (AAR, APRI, FIB-4, API) scores. Patients were asked to complete the HADS and FSS measures in order to gauge their psychological condition.
Results
In this study, 200 patients were examined. Anxiety was present in 6.5%, depression in 21%, and increased fatigue severity in 27%. AAR was significantly higher in patients with depression (p=0.008). FIB-4 score was significantly higher in those with anxiety (p=0.037) and showed a limited significant difference in fatigue (p=0.052). APRI values were significantly higher in the increased fatigue severity group (p=0.004). Multivariate analyses showed that liver fibrosis significantly increased the risk of depression (OR=2.35, p=0.036), and increasing age decreased the risk of depression (p=0.025). Significantly lower anxiety risk was associated with marriege (OR=0.06, p=<0.001). Patients on antiviral therapy had a 2-fold increase in fatigue severity (OR=2.07, p=0.027).
Conclusions
This study highlights the link between psychiatric symptoms and liver disease progression in CHB patients. The observed associations between liver fibrosis, depression, and fatigue underscore the importance of a holistic approach to CHB management that integrates mental health support. Such an approach may improve patient outcomes and overall quality of life.
Investigation of Anxiety and Depression in Female Patients with Fibromyalgia on MR Images: A cross-sectional cohort study
Authors: ÇİÇEK Fatih , PAYAS Ahmet , SEBER Turgut , DEMİR Fatma Gül Ülkü , DAĞ Selman SOLGUN , UÇAR İlyas , ÇİFTÇİ Ali Türker 
Published: January 2025

Abstract

Background
High rates of depression and anxiety have been reported in patients with fibromiyalgia (FM). Therefore, the aim of our study was to determine the volume of the amygdala, medial frontal cortex, limbic system and hippocampus in participants with anxiety and depression and to compare the fibromyalgia and control groups by determining the afferent and efferent fibers of the amygdala, which play an important role in anxiety and depression, which will be the first in the literature.
Methods
Only female subjects, 30 with fibromyalgia and 30 controls, were included in this study. Visual analog scale was used for pain sensation, BECK depression inventory, Hospital anxiety and depression scale were used for anxiety and depression. From brain diffusion MR images, tractography of the targeted pathway was calculated in DSI Studio software and the volume of targeted structures was calculated in VolBrain software program.
Results
The total volume of the medial frontal cortex, amygdala, limbic cortex and hippocampus was found to be statistically significant higher in the control group than in the fibromyalgia group (p < 0.05). It was also found statistically significant (p < 0.05) that the total number of fibers on the right side of the amygdala was higher in the patient group (13710.60 ± 4926.09) than in the control group (13099.14 ± 3677.12), but the number of fibers on the left side was higher in the control group (4057.37 ± 1388.57) than in the patient group (3552.70 ± 1493.35).
Conclusions
It is observed that depression and anxiety in fibromyalgia patients affect both white matter and gray matter volume in the central nervous system. Therefore, we believe that treatments on the central nervous system may be more effective in the treatment of anxiety and depression disorders in patients with fibromyalgia.
Metallurgical recovery of rare earth elements: A bibliometric analysis and systematic literature review
Authors: Cotrina-Teatino Marco Antonio , Marquina-Araujo Jairo Jhonatan , Alva-Gaspar Wilmer , Cruz-Ulloa Alex Jhonatan 
Published: January 2025

Abstract

This article aimed to comprehensively map research on the metallurgical recovery of rare earth elements (REEs) in the mining industry from 2010 to 2024, identifying key themes, trends, and future directions. Using a mixed-methods approach that included bibliometric analysis, text mining, and content analysis, the study pursued the following objectives: (i) to capture the scientific background of research on the metallurgical recovery of REEs, identifying key themes and trends over the past 14 years, (ii) to provide a comprehensive overview of the existing literature on the topic, and (iii) to propose future directions in this field. A total of 132 peer-reviewed articles were analyzed, sourced from the Scopus, JSTOR, and Taylor & Francis databases, and selected using the PRISMA method and ad hoc sampling. The analysis identified three primary research areas: (1) innovation in rare earth recovery, (2) environmentally friendly metallurgical methods contributing to sustainability, and (3) challenges and perspectives on recycling and reusing rare earth elements. Based on these findings, three future research lines were proposed: Optimization and Integration of Hybrid Processes for Sustainable REE Recovery, Technological Advancements in Selective Recovery and REE Processing y Closed-Loop Systems and Biotechnological Solutions for REE Recycling. These efforts aim to enhance sustainability and optimize resource utilization in the mining industry, promoting practices that contribute to a more responsible, efficient, and sustainable development model for REE recovery.
Joint Effects of Calcium Carbonate in Domestic Water and the Genetic Risk on Rheumatoid Arthritis
Authors: Tian Dandan , Li Panlong , Chen Lijuan , Li Wanyue , Zhu Xirui , Huang Chun , Tian Shan , Li Yuna , Qiao Yuan , Yang Junting , Cao Shanshan , Cong Chaohua , Zhao Lei , Su Jingjing , Liu Min , Hao Yibin , Li Ninghua 
Published: January 2025

Abstract

Background: The aim of this study was to investigate the relationship between minerals in domestic water and the incidence of rheumatoid arthritis (RA).
Methods: This longitudinal observational study included 434,958 British individuals from the United Kingdom. The study population consisted of RA-free participants with complete information on water minerals, genetic data, lifestyle habits, and physical measurements at baseline. The baseline assessment was conducted between 2006 and 2010, and the follow-up period was up to 2024. To assess individual genetic susceptibility, a polygenic risk score (PRS) of RA was calculated for each participant. Cox regression models were employed to examine the associations between water minerals, the PRS, and the occurrence of RA.
Results: A total of 5,880 new RA cases were reported during a median follow-up of 15 years. After controlling for multiple covariates, the concentration of calcium carbonate in domestic water was negatively associated with the risk of RA (hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.90 to 0.95; p=1.74×10-9). Additionally, individuals in the highest tertile of the polygenic risk score (PRS) had a 53% to 74% increased risk of RA compared with those in the lowest tertile. Notably, individuals with a high PRS and soft water had a 92% (95% CI: 71% to 115%) increased risk of RA compared with those with a low PRS and very hard water.
Conclusions: The results suggest that exposure to soft water increases the risk of RA, especially in people who are genetically susceptible.
A fluorescent probe for sensing of hydrogen sulfide in living cells by adopting the adjacent-group participation strategy
Authors: Du Yuting , Wang Hongliang , Xu Xingyu , Wang Jiayi , Guo Minmin , Sun Jinyu 
Published: January 2025

Abstract

Hydrogen sulfide (H2S) is recognized as a critical gas signal molecule in the development and treatment of various diseases. Therefore, the development of a potent fluorescent probe for the detection of H2S is of great significance in biological systems. Herein, we synthesis of a new fluorescent probe, 3-(benzo[d]thiazol-2-yl)-2-(2,4-dinitrophenoxy)-5-methylbenzaldehyde (DPM-H2S) to detect H2S based on the recognition strategy that uses an ortho-aldehyde group to facilitate the thiolysis of dinitrophenyl ether, which results in its ultrafast response to H2S within 5 s together with a large Stokes shift of 106 nm. Under the excitation of 436 nm, after adding H2S to the probe, the fluorescence emission at 542 nm was greatly enhanced, and the fluorescence intensity was gradually strengthened with the increase of the amount of H2S, which had a good linear relationship with good limit of detection (LOD) of 4.9 µM. The probe DPM-H2S reacts with H2S to release its precursor 3-(benzo[d]thiazol-2-yl)-5-bromo-2-hydroxybenzaldehyde (DPM) and realizes the fluorescence “turn on” type response. Furthermore, the probe has been successfully applied for imaging hydrogen sulfide (H2S) in living HeLa cells. Additionally, the dual-side expansion strategy for regulating the optical features of traditional fluorophores could meet the increasing demands of sensing and imaging applications.
Impact of Central Obesity on Bone Mineral Density Across Life Stages: A Genetic Epidemiology and Cross-Sectional Study
Authors: Galvis Camilo Alberto Pinzon , Jiang Yuhong , Huang Xianhao , Wang Cui , Wu Jialu , Tian Li , Li Ning , Lu Lingyun 
Published: January 2025

Abstract

Introduction:
This study aimed to investigate the association and causality between central obesity and bone mineral density (BMD).
Methods
We utilized linkage disequilibrium score regression (LDSC) and Mendelian randomization (MR) to assess genetic correlations and causal relationships between waist circumference adjusted for BMI (WCadjBMI) and total body less head BMD (TB-BMD). Additionally, a cross-sectional analysis of 7,452 participants evaluated the relationship between A body shape index (ABSI) and TB-BMD using weighted multivariable linear regression and smooth curve fitting.
Results
LDSC and MR analysis confirmed a negative relationship between WCadjBMI and TB-BMD (β=-0.16; 95% CI: -0.26, -0.07). The cross-sectional study indicated that an increase of 0.01 ABSI corresponded to a decrease of 0.035 TB-BMD (g/cm2), with this negative effect being particularly pronounced in males and older adults. An inflection point was identified at ABSI = 0.076: below this threshold, ABSI positively correlated with pelvis BMD, whereas above it, the association became negative.
Conclusions
Central obesity is significantly negatively related to BMD. Maintaining ABSI within 0.058–0.078 is crucial for individuals in bone mass accrual (20–30 years) and stabilization (30–45 years) periods. In contrast, managing central obesity in people experiencing early bone loss (45–60 years) presents greater complexity and warrants further investigation.
Living with dementia and other long-term conditions: what works for patient/caregiver dyads? A realist review
Authors: Handley Melanie , Windle Greg , Mathie Elspeth , Greco Honey-Anne , Underwood Ben , Surr Claire , Dening Karen Harrison , Milton Steve , Pujari Amit , Lebcir Reda M , Lynch Jennifer , Beishon Lucy , Sampson Elizabeth L , Scherer Reinhold , Goodman Claire 
Published: January 2025

Abstract

Objectives
Globally, increasing numbers of people are living with multiple long-term conditions. When dementia is a co-occurring condition, contact with services is complicated due to the person’s cognitive difficulties and is often achieved as a dyad (person and carer). This realist review aimed to explain how dyads living with dementia alongside other long-term conditions are enabled (or not) to access and navigate health and care systems.
Method
An iterative, three stage approach synthesised evidence from empirical studies and stakeholders with lived and professional experience (ethics reference 23/LO/0829).
Results
Evidence from 61 studies and stakeholders (30 participants, 68 consulted) built and refined five programme theories for how health and care systems can achieve continuity of support, anticipate adverse events and maintain quality of life. Belief that concerns would be listened to and acted upon led dyads to seek assistance. Time and permission to discuss priorities, prognosis and acceptable levels of burden enabled uncertainties to be managed as a shared endeavour. The collective capacity of the dyad was enhanced by peer support, expertise they accrued over time and professionals who helped anticipate points of change.
Conclusion
Despite years of system changes, structural factors still create excessive burdens for dyads accessing services and constrain professionals’ ability to respond to complex needs.
Urbanization-informed, uncertainty-based calibration approach for simulating the impact of urbanization on flooding in a data-limited region
Authors: Nithila Devi N. , Kuiry Soumendra Nath 
Published: January 2025

ABSTRACT
Rapid urbanization necessitates reliable assessments of its impact on flooding. The two major challenges in data-sparse basins are the equifinality of the hydrological parameters and their dynamic updating with respect to changing land use and land cover. Existing calibration approaches typically address only one of these challenges. The existing approaches that allow for dynamic updating of parameters with changing land use and account for parametric uncertainty are referred to as Dyn_CN and uStat_CN, respectively. We propose a novel ‘urbanization-informed uncertainty-based calibration approach’, referred to as uDyn_CN, that combines the advantages of both these approaches. The existing and proposed calibration approaches were applied to India's data-limited, frequently flooded, urbanizing Adyar river basin comprising Chennai city. The performance assessment of the methodologies was done in an externally coupled hydrological-hydraulic modelling framework. In that light, the proposed hydrological calibration approach is more accurate than the existing approaches in both the hydrological and hydraulic simulations. For instance, the RMSE values for the simulated maximum water depths for uDyn_CN, uStat_CN, and Dyn_CN approaches are 0.22, 0.36, and 0.6 m, respectively. The study also demonstrates its subsequent application to analyze the impact of urbanization on flood hazard in the Adyar basin by 2050.
Cost-effective evaluation of modified ochre soil and its combination with cationic polyacrylamide for municipal wastewater sludge conditioning
Authors: Aghababaei Behzad , Taheriyoun Masoud , Mahdavi Far Rana 
Published: January 2025

ABSTRACT

One of the most costly stages of activated sludge wastewater treatment plants is the treatment and dewatering of waste sludge. Chemical conditioning of sludge, as one of the most widespread methods to enhance sludge dewaterability, accounts for a significant portion of operational expenses due to the consumption of expensive polymeric compounds. This research aims to assess the cost-effectiveness of ochre soil, modified with hydrochloric acid, as an affordable mineral for conditioning waste sludge in an activated sludge system. The optimal conditions for acid modifications are obtained using response surface methodology. Then, its performance is compared with conventional coagulants (ferric chloride and alum) and in combination with cationic polyacrylamide (CPAM). To assess the conditioning process efficiency, the specific resistance to filtration (SRF) parameter was employed. At an optimal dose of modified ochre soil (MOS) equal to 300 (mg/g dry solids), the SRF value decreased from 31.96 to 2.7 Tm/kg. The combination of 100 (mg/gDS) MOS with 0.5 (mg/gDS) CPAM showed as the most cost-effective among the coagulants tested, with a 31% greater SRF reduction compared to CPAM used alone. This study shows the practical efficacy of an eco-friendly natural mineral as a polymer alternative, with the potential for sludge dewatering.