bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning-based NT-proBNP prediction from the ECG for risk assessment in the community
Authors: Neyazi Meraj , Bremer Jan P. , Knorr Marius S. , Gross Stefan , Brederecke Jan , Schweingruber Nils , Csengeri Dora , Schrage Benedikt , Bahls Martin , Friedrich Nele , Zeller Tanja , Felix Stephan , Blankenberg Stefan , Dörr Marcus , Vollmer Marcus , Schnabel Renate B. 
Published: November 2023

Abstract

Objectives
The biomarker N-terminal pro B-type natriuretic peptide (NT-proBNP) has predictive value for identifying individuals at risk for cardiovascular disease (CVD). However, it is not widely used for screening in the general population, potentially due to financial and operational reasons. This study aims to develop a deep-learning model as an efficient means to reliably identify individuals at risk for CVD by predicting serum levels of NT-proBNP from the ECG.

Methods
A deep convolutional neural network was developed using the population-based cohort study Hamburg City Health Study (HCHS, n=8,253, 50.9 % women). External validation was performed in two independent population-based cohorts (SHIP-START, n=3,002, 52.1 % women, and SHIP-TREND, n=3,819, 51.2 % women). Assessment of model performance was conducted using Pearson correlation (R) and area under the receiver operating characteristics curve (AUROC).

Results
NT-proBNP was predictable from the ECG (R, 0.566 [HCHS], 0.642 [SHIP-START-0], 0.655 [SHIP-TREND-0]). Across cohorts, predicted NT-proBNP (pNT-proBNP) showed good discriminatory ability for prevalent and incident heart failure (HF) (baseline: AUROC 0.795 [HCHS], 0.816 [SHIP-START-0], 0.783 [SHIP-TREND-0]; first follow-up: 0.669 [SHIP-START-1, 5 years], 0.689 [SHIP-TREND-1, 7.3 years]), comparable to the discriminatory value of measured NT-proBNP. pNT-proBNP also demonstrated comparable results for other incident CVD, including atrial fibrillation, stroke, myocardial infarction, and cardiovascular death.

Conclusions
Deep learning ECG algorithms can predict NT-proBNP concentrations with high diagnostic and predictive value for HF and other major CVD and may be used in the community to identify individuals at risk. Long-standing experience with NT-proBNP can increase acceptance of such deep learning models in clinical practice.
Counting integral points of bounded height on varieties with large fundamental group
Authors: Brunebarbe Yohan , Maculan Marco 
Published: November 2023

Abstract
The main result
of this paper states the subpolynomial growth of the number of integral points with bounded height of a variety over a number field whose fundamental group is large. This generalizes a recent paper of Ellenberg, Lawrence and Venkatesh and replies to two questions asked therein.
The Levantine Roots of thetophetSanctuary
Authors: Xella Paolo 
Published: November 2023

AbstractPhoenician and Carthaginian infant cremation sanctuaries (tophet), attested throughout the central Mediterranean (north Africa, Sardinia and Sicily, and perhaps Malta), up to this point lack convincing archaeological evidence in the Phoenician motherland and the far western Mediterranean. This study collects and re-examines the evidence of its Levantine origin of historical order, (the chronology of the settlements and the almost contemporary installation oftophetprecincts in them), epigraphic (the inscription of Nebi Yunis) and literary (biblical testimonies and some Greek and Latin writers). Taken as a whole, this documentation strongly leads us to exclude an explanation of thetophetas a novelty introduced by the migrants, but an ancient traditional institution that derived in all probability from the city of Tyre.
Memes as multimodal ensemble
Authors: Koickakudy Mitul Joseph , Karakunnel Meljo Thomas 
Published: November 2023

Abstract
Memes have now become a common medium of communication. There are multiple ways memes are considered in academia. Semiotics offers information on how the media and modes that memes consist of can be interpreted and how the characteristics of semiotic resources apply to memes. Drawing from a pool of memes collected during the Kerala assembly election in 2021, this research argues that certain memes need to be categorised as multimodal ensemble. Different modalities play different roles meaning construction, and they also collaborate with each other for a uniform purpose. By comparing existing memes defined in academia and multiple methodologies to analyse memes, the paper puts forth a framework to analyse memes.
The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies
Authors: Parrilla Gabriella E. , Gupta Vivek , Wall Roshana Vander , Salkar Akanksha , Basavarajappa Devaraj , Mirzaei Mehdi , Chitranshi Nitin , Graham Stuart L. , You Yuyi 
Published: November 2023

Abstract
Myelination of axons in the central nervous system offers numerous advantages, including decreased energy expenditure for signal transmission and enhanced signal speed. The myelin sheaths surrounding an axon consist of a multi-layered membrane that is formed by oligodendrocytes, while specific glycoproteins and lipids play various roles in this formation process. As beneficial as myelin can be, its dysregulation and degeneration can prove detrimental. Inflammation, oxidative stress, and changes in cellular metabolism and the extracellular matrix can lead to demyelination of these axons. These factors are hallmark characteristics of certain demyelinating diseases including multiple sclerosis. The effects of demyelination are also implicated in primary degeneration in diseases such as glaucoma and Alzheimer’s disease, as well as in processes of secondary degeneration. This reveals a relationship between myelin and secondary processes of neurodegeneration, including resultant degeneration following traumatic injury and transsynaptic degeneration. The role of myelin in primary and secondary degeneration is also of interest in the exploration of strategies and targets for remyelination, including the use of anti-inflammatory molecules or nanoparticles to deliver drugs. Although the use of these methods in animal models of diseases have shown to be effective in promoting remyelination, very few clinical trials in patients have met primary end points. This may be due to shortcomings or considerations that are not met while designing a clinical trial that targets remyelination. Potential solutions include diversifying disease targets and requiring concomitant interventions to promote rehabilitation.
A Discussion of Exercise Programs Performed During Firefighter Training Academies
Authors: Mang Zachary A. , Beam Jason R. , Martinez Adam H. 
Published: November 2023

ABSTRACTFirefighting is a physically demanding occupation that requires individuals to possess considerably high levels of muscular endurance, strength, power, and aerobic fitness. Under most circumstances, a firefighter's career begins with a training academy during which they learn essential job tasks (e.g., victim rescue) while performing a variety of exercise programs. Based on the current literature, several forms of resistance, aerobic, circuit, concurrent, and functional training positively affect the physical fitness and occupational performance of firefighter recruits. Because many fire departments have limited gym access, it is most practical for training academies to adopt exercise programs that can be completed with their academy's specific equipment and facility confines. Luckily, the research discussed within this paper demonstrates that effective training can be performed with minimal and maximal facility/equipment access. Regarding future studies, it would be interesting for researchers to compare the effects of minimal-equipment and maximal-equipment programs and apply training plans that combine these 2 extremes. Moreover, to accommodate the execution and learning of occupational tasks, researchers should explore periodizing training plans around the current physical demands of the academy while applying minimum effective training doses.
A Discrete Time Geometric Queue Attached to an Inventory under a (0, Q) Policy
Authors: Sivasamy R , Setlhare K. , Molefe W.B. , Mokgwar Olebogeng 
Published: November 2023

This paper describes how a threshold policy, or TP = [(0, Q), 1]-based inventory management, economically offers customers a single product with a discrete time geometric queue attached to a Geo/Geo/1 service base. The order for Q units starts when inventory I(t) at time ’t’ drops to the level ’0’, and the length of the queueing process X(t) is at least one. We focus on the process Z(t) = (X(t), I(t)), t [0, ?). We then analyse the steady state probabilities and then provides a numerical study for graphing the economic order quantity.
Portal Vein and Superior Mesenteric Vein Invasion of Hydatid Cyst of The Liver: Surgical Treatment Option
Authors: Sapmaz Ali , Cicek Egemen , Yilmaz Serhan , Bolukbasi Hakan , Soykurt Ahmet , Hazinedaroglu Selcuk Mevlut 
Published: November 2023

Hydatid cyst is a parasitic infestation by a tapeworm of the genus Echinococcus granulosus which can be localized in all vascularized tissues and causes cystic lesions. We present a case of hydatid liver cyst with portal vein and superior mesenteric artery invasion. Hydatid cysts are still commonly seen in Turkey. We believe that the most efficacious and least morbid treatment alternative for such rare complications of hydatid cysts is surgery.
Exploring the eighteenth-century concept of soil as reflected in Sámuel Domby's De vino Tokaiensi
Authors: Sipos Eszter 
Published: November 2023

AbstractThe treatise De vino Tokaiensi (On Tokaj Wine) written by Sámuel Domby of Gálfalva (1729–1807), is a valuable source on Hungarian history of culture and science which has become widely accessible thanks to its facsimile edition. This medical doctoral dissertation published in 1758 in Utrecht presents a study of the medicinal effects of Tokaj wine, mirroring the norms of philosophical-scientific literature in eighteenth century Hungary. It is unequivocally an exceptional document of the intellectual heritage of the educated classes in the early modern age regarding growth habitat, viticulture and winemaking, with specific reference to Tokaj-Hegyalja, a wine region and cultural landscape of historic importance in Northeast Hungary. The present paper aims at identifying the perceptions detailed in the candidate's argument in pedological terms.
Latin paraphrases of Old Testament books in verse in 16th century Hungary
Authors: Posta Anna 
Published: November 2023

AbstractA popular trend in 16th-century Hungarian Neo-Latin poetry was the transposition of biblical, especially Old Testament books and texts. Georg Purkircher (Georgius Purkircher) paraphrased the Book of Wisdom, Péter Laskai Csókás (Petrus C. Lascovius) the Song of Songs, János Bocatius (Johannes Bocatius) the Book of Sirach/Ecclesiasticus, and Leonhardus Mokoschinus (Leonhardus Mokoschinus) a part of the Old Testament books (from Genesis to II Kings) in Latin. Internationally, only Mokoschinus' paraphrase of the Old Testament is known to any extent. In the present paper I will attempt to outline the main similarities and differences between the paraphrases of the Old Testament in Germany and in Hungary by means of a detailed philological analysis of the domestic corpus of texts and by highlighting some related parallels in Germany.
Modeling of pressure losses in a cylindrical duct with rectangular ribs
Authors: Chouchane Nacer , Chouchane Hammam , Chouchane Tesnim 
Published: November 2023

AbstractIn order to improve the thermal performance of heat exchangers and air collectors, we insert various forms of artificial roughness, known as ribs, into the useful duct. These ribs promote the creation of turbulent flows and enhance heat transfer by conduction, convection and radiation.However, the introduction of these ribs leads to an increase in pressure drop, requiring higher mechanical power to pump the heat transfer fluid. This experimental study focuses on estimating, using empirical approaches, the pressure losses induced by rectangular ribs with an inclined top. The ribs are made from 0.4 mm galvanized sheet steel.An experimental set-up was designed to measure the head losses generated by the ribs, from the point of entry to the point of exit from the useful duct. Using the dimensional analysis method, correlations were established to evaluate head losses as a function of flow regime and rib geometry and configuration (including different geometries for rib arrangement over the configuration area).
Sôshokukei kara asuparabêkon made! ‘From herbivores to bacon-wrapped asparagus!’
Authors: Willis Chloe 
Published: November 2023

Japanese essayist Maki Fukasawa coined the term sôshoku danshi ‘herbivore men’ to refer to men who are not assertive or proactive in engaging with romantic or sexual relationships with women. Since her 2006 article, dozens of related kei ‘types’ have proliferated across the digital landscape, creating a taxonomy of binary-based gender classifications. This article describes the kei system through an analysis of digital texts, first providing the historical context of this discourse, then overviewing its grammar and taxonomic structure. An analysis of heuristic types then reveals how heteronormativity and gender hegemony emerge and limit the subversive potential of this system. Finally, the article discusses how neoliberalism creates the niche occupied by kei and enables its sustained appeal. The article contributes to research on both kei and identity by analysing kei as a system, attending to the ways in which broad social forces shape self-identification.
Kinetics of nitric acid leaching of bornite and chalcopyrite
Authors: Shklyaev Yuri , Dizer Oleg , Lugovitskaya Tatiana , Golovkin Dmitry , Rogozhnikov Denis 
Published: November 2023

The paper presents a study of the process of nitric acid dissolution of the natural minerals chalcopyrite and bornite. The influence of various parameters, including temperature, nitric acid concentration and particle sizes, on this process was examined. Based on the data obtained, the values of apparent activation energy (57.41 and 42.98 kJ/mol for chalcopyrite and bornite, respectively), empirical orders with respect to nitric acid (1.62 and 1.57 for chalcopyrite and bornite, respectively) and with respect to particle size (–1.16 and –2.53 for chalcopyrite and bornite, respectively) were calculated using the shrinking core model. Generalized kinetic equations for the dissolution process of both minerals were derived. Based on the calculations performed, it was suggested that the dissolution processes of chalcopyrite and bornite under these conditions are limited by internal diffusion.
Data of bioaccumulation and biomagnification from soil in biota nettle-snail (Urtica dioica, L and Helix pomatia,L) of heavy metal (Pb, Zn, Ni) pollution of mining activity in Mitrovica.
Authors: Bici Mentor , Bislimi Kemajl 
Published: November 2023

ABSTRACT
In this research project, we measured the impact and distribution of the activity of minning Trepça Complex in Mitrovica on the concentrations of heavy metals (Pb, Zn, Ni) in soil, plant (Urtica dioica,L) and shell of snail (Helix pomatia).
Introdiction: Large quantities of these metals come from natural and anthropogenic sources including mining activity, agriculture, pesticide use, industrialization, and inadequate disposal of mineral waste and artificial fertilizers. These inorganic pollutants are deposited in the soil, water, and atmosphere in various forms of complexes and are thus transmitted from plants, animals to humans. Climatic factors such as winds, rains, and temperatures are believed to be major contributors to the spread over time and space of heavy metals in the environment.
Materials and methods: Soil samples, nettle plant (Urtica dioica, L), and snail (Helix pomatia, L), were collected from the selected pollution source of mine Trepça complex at distances of 1km, 2km, and 5km in the radius circles divided into four geographical areas. Also the control samples are collected in unpolluted site Opoja-Dragash municipalty. The samples were digested in microwave at 2000C for 45 min and have been read in flame absorber Analyticjena Contra AAA.
Results: Higher concentrations of Pb, Zn, and Ni were recorded in the southern parts of the country compared to that control with significant differences (p<0.01). Bioaccumulation and biomagnification levels of these heavy metals have also been recorded in the roots, stalks, and leaves of the stinging nettle plant (Urtica dioica, L) as well as in snail shells (Helix pomatia, L.).
Conclusions: The results show that the stinging nettle plant has translocated larger amounts of these heavy metals especially Pb along with the vegetative organs wherefrom these they are carried in the snail shell, which is fed on the stinging nettle plant.
Also, results shown that the nettle plant Urtica dioica can be used in phytoremediation process whereas snail Helix pomatia can be used like bioindicator of heavy metal pollution.
Texto guía en el laboratorio de procesos psicológicos
Authors: Muñoz Olano Juan Francisco , Acevedo Triana Cesar Andres 
Published: November 2023

El texto guía en el laboratorio de Procesos psicológicos es un manual introductorio para psicólogos en formación y demás personas interesadas, que combina una aproximación cognoscitiva al funcionamiento mental, con una orientación práctica en la realización de diez experimentos psicológicos. Desde lo conceptual y teórico, los procesos psicológicos son abordados como originalmente fueron considerados por el padre del funcionalismo, Wllim Jams; como experiencias sujetivas de la consciencia, con finalidades adaptativas en la historia de la evolución humana. No obstante en la presente obra los procesos psicológicos también son estudiados como actividades mentales que usan ilusiones y esfuerzo mental, considerando los aportes más contemporáneos de investigadores en el campo, como Edward Smith, Stephen Kosslyn, Daniel Kahneman y Daniel Gilbert. El presente texto se especializa en brindar herramientas prácticas para la formación de investigadores en psicología. Es así como incluye una descripción del trabajo propio de la psicología Básica de la clasificación y medición de los fenómenos psicológicos, junto con una orientación en los procesos de deducción e inducción requeridos para probar hpótesis experimentales y presentarlas en un informe de laboratorio.
Exhumación
Authors: García Gil Carlos Eduardo 
Published: November 2023

El autor de la presente obra poética pretende un acercamiento a la problemática la la eutanasia y la vejez, bajo el sustento del paso del tiempo, el olvido y la reemplazabilidad, como experiencia propia de la época presente. Asimismo, como vía probable, el lenguaje poético se ubica, en esta obra, en un plano de reconstrucción de vivencias y emociones, en tanto alternativas de significación y comprensión.
Nutrición animal, lípidos y fitoestrógenos
Authors: Rodríguez Molano Carlos Eduardo , Fonseca López Dania Alejandra 
Published: November 2023

En esta obra, se presentan resultados de investigaciones desarrolladas dentro del Grupo de Investigación en Bioquímica y Nutrición Animal (GIBNA) de la Universidad Pedagógica y Tecnológica de Colombia derivadas del proyecto: "Efecto de la etapa de lactancia sobre la calidad fisicoquímica de la leche en vacas de raza holstein y normando", trabajos realizados en el departamento de Boyacá, principalmente en lugares entre los 1500 y 2700 msnm, con el objetivo de reducir dicha brecha. Así, en esta obra se recopila información relevante de los avances obtenidos con el uso de lípidos, grasa o grasa sobrepasante y alimentos con aporte de fitoestrógenos en relación con algunos parámetros productivos y reproductivos de rumiantes.
Solón y el nacimiento de la racionalidad legislativa
Authors: Patiño Rojas Jorge Enrique 
Published: November 2023

En la obra se toman fuentes primarias con la intención de estudiar los poemas y leyendas escritos por Solón, haciendo dentro del mismo una realizable comprensión de los textos expuestos por él de la misma manera se analizan las de los autores que, sabemos, son fuente indirecta, pero algunos coetáneos de Solón, por lo que pasan a tener la virtud fundamental de conjugar idéntico mundo de vida. De manera general, se resalta de la obra de Solón, la introducción de la razón(incluida la razón democrática de los hombres), en la construcción de la disciplina jurídica, antes que en los demás campos de estudio, lo que implica, ni más ni menos, que se puede constituir en el primer germen de la ciencia y no sólo del mero derecho. Se estructura en once breves capítulos.
Aplicaciones de la teoría de colas y línea de espera en contextos específicos de investigación
Authors: Burbano Pantoja Víctor Miguel Ángel , Valdivieso Miranda Margoth Adriana , Burbano Valdivieso Ángela Saray 
Published: November 2023

En este libro se describen los procesos investigativos tendientes a indagar y reflexionar en torno a la teoría de colas y líneas de espera centrada en modelos aleatorios. El estudio tuvo como objetivo averiguar aspectos teóricos sobre algunos modelos estocásticos aplicable a líneas de espera de la forma M/M/1 y, en general, de la forma A/B/C, que especialmente pudieran posibilitar el análisis de algunos casos particulares de colas en determinados contextos. El proceso metodológico se desarrolla con un enfoque cuantitativo de investigación y centrado en el estudio de tres casos específicos. En este sentido, se diseñaron los instrumentos para la recogida de información, se efectuó un análisis de la misma, se generaron modelos probabilísticos y se calcularon diversas medidas de desempeño para tres sistemas de colas. El texto permite abordar aspectos conceptuales sobre la teoría de colas y líneas de espera, componentes básicos de un sistema de colas, modelos de líneas de espera con sus respectivas medidas de eficiencia, distribuciones de probabilidad usuales destinadas a modelar tanto los fenómenos de colas como los tiempos de servicio, tales como las Poisson, la Gamma, la de Erlang y la exponencial, y no usuales como la Distribución Lambda Generalizada (DLG).
Políticas y medición en ciencia y tecnología en la universidad colombiana 1992-2014
Authors: Gómez Velasco Nubia Yaneth , Soto Arango Diana Elvira , Jardilino Jose Rubens Lima 
Published: November 2023

La investigación involucra componentes de carácter cualitativo y cuantitativo, enfocados en la interpretación de documentos, que permiten generar una trazabilidad en los periodos socio históricos abordados; así como en el análisis de indicadores bibliométricos y uso de técnicas estadísticas que brinda una mirada complementaria al objeto de estudio. La investigación genera aportes en el enfoque metodológico utilizado, el marco historiográfico asociad a Ciencia y Tecnología y los resultados que podrán servir de referencia a otras investigaciones.