bluuebunny/crossref_metadata_2025_split huggingface dataset:
The roles of vicarious trauma exposure and perceived social support in codeine syrup misuse among Black men living in prisons
Authors: Dogan‐Dixon Jardin , Thrasher Shawndaya S. , Thorpe Shemeka , Wheeler Paris , Stevens‐Watkins Danelle 
Published: October 2023

AbstractUsing General Strain Theory, this study investigates the effects of vicarious trauma exposure and perceived social support on nonmedical codeine syrup misuse among Black incarcerated men nearing community re‐entry. Data were drawn from the Helping Incarcerated Men project, a study examining mental health, substance misuse, and human immunodeficiency virus (HIV) risk behaviors among Black men living in prisons who were within 180 days of release. A total of 200 Black men self‐reported demographics (i.e., age and length of incarceration after age 18), vicarious trauma exposure (e.g., ever witnessing an assault with a weapon and a sudden accidental death), perceived social support, and nonmedical codeine syrup misuse. Findings from the logistic regression analysis showed witnessing an assault with a weapon and a sudden accidental death increased the likelihood of codeine syrup misuse. Perceived social support was not associated with codeine syrup misuse. Implications for practice and future research are discussed.
Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F‐actin/YAP signaling pathway
Authors: Zhou Yuhao , Lv Wenjun , Peng Xiufen , Cheng Yansiwei , Tu Yun , Song Guanbin , Luo Qing 
Published: October 2023

AbstractSkin and its cell components continuously subject to extrinsic and intrinsic mechanical forces and are mechanical sensitive. Disturbed mechanical homeostasis may lead to changes in skin functions. Gravity is the integral mechanical force on the earth, however, how gravity contributes to the maintenance of skin function and how microgravity in space affects the wound healing are poorly understood. Here, using microgravity analogs, we show that simulated microgravity (SMG) inhibits the healing of cutaneous wound and the accumulation of dermal fibroblasts in the wound bed. In vitro, SMG inhibits the migration of human foreskin fibroblast cells (HFF‐1), and decreases the F‐actin polymerization and YAP (yes‐associated protein) activity. The SMG‐inhibited migration can be recovered by activating YAP or F‐actin polymerization using lysophosphatidic acid (LPA) or jasplakinolide (Jasp), suggesting the involvement of F‐actin/YAP signaling pathway in this process. In SMG rats, LPA treatment improves the cutaneous healing with increased dermal fibroblasts in the wound bed. Together, our results demonstrate that SMG attenuates the cutaneous wound healing by inhibiting dermal fibroblast migration, and propose the crucial role of F‐actin/YAP mechano‐transduction in the maintenance of skin homeostasis under normal gravity, and YAP as a possible therapeutic target for the skin care of astronauts in space.
Acceptability of an online communication training intervention for genetic counseling students
Authors: Lowe Chenery , Erby Lori , Joseph Galen , Biesecker Barbara , Roter Debra L. 
Published: October 2023

AbstractTechnology provides opportunities to enhance communication skills training for genetic counseling graduate students. We assessed the acceptability of an online communication training program. Graduate student volunteers completed five online training modules on basic communication skills with opportunities to practice the skills within three simulated/standardized patient (SP) sessions. Participants completed online questionnaires reporting on acceptability, perceived usefulness, and realism of the modules and SP sessions. They also reported on the ease of transferring skills from the modules to clinical practice. Out of the 60 students who completed the baseline session, 35 (58%) completed all five training modules. Out of these 35 students, most found the modules to be useful (94%) and agreed that they were relevant to clinical practice (97%). At least 88% of participants found the genetic counselors, patient, and case scenarios to be realistic. Twenty‐eight students had participated in clinical rotations since completing the intervention. Of these, 17 (61%) reported that it was at least slightly easy to use the skills in actual clinical cases. Most students also reported being able to transfer the skills they had learned into clinical practice. While the training was well‐received, the relatively low completion rate of 58% raises concern that the intervention may need formal integration into the program curriculum to succeed due to the time and effort demands on students.
No evidence for systemic low‐grade inflammation in adult patients with early‐treated phenylketonuria: The INGRAPH study
Authors: Giret Chloé , Dos Santos Yann , Blasco Hélène , Paget Christophe , Gonzalez Loïc , Tressel Nathalie , Dieu Maeva , Bigot Adrien , Gissot Valérie , Audemard‐Verger Alexandra , Maillot François 
Published: October 2023

AbstractThe question of an increased cardiovascular risk has been recently raised in adults with phenylketonuria (PKU). As low‐grade systemic inflammation increases cardiovascular risk, the INGRAPH study aimed to evaluate low‐grade inflammation in adult PKU patients compared to healthy controls and to determine the potential influence of Phe‐controlled diet on inflammation. Twenty early‐treated adult PKU patients, including a subgroup of 15 classical PKU patients, and 20 healthy volunteers were included. PKU patients and healthy subjects were matched on age, sex and body mass index class. Plasma concentrations of CRP, IFNg, IL1a, IL1b, IL2, IL6, IL10, and TNFα were measured in PKU patients and compared to controls. Plasma CRP was not different in the PKU group as compared to controls. No significant differences were observed between the two groups concerning plasma cytokines concentrations. Plasma CRP and cytokine profile were not different between “on diet” and “off diet” PKU patients. All these results were similar considering only the classical PKU subgroup. No differences were shown in plasma CRP and pro‐inflammatory cytokines between adult PKU patients and healthy controls. Further studies are needed, including more patients and extensive characterization of systemic low‐grade inflammation, as cardiovascular risk appears to be a new concern in adult PKU population.
Withdrawn: The Property of a Novel Cross‐Linked Foam from Thermoplastic Phenol‐Terminated Polyphenylene Ether Resin with High Molecular Weight Cured by Hydroxymethylated Phenol‐Terminated Polyphenylene Ether Resin with Low Molecular Weight
Authors: Li Tingting , Gao Wenhan , Yu Ruobing , Xia Rui , Chang Bu 
Published: October 2023

AbstractWithdrawal: Tingting Li, Wenhan Gao, Ruobing Yu, Rui Xia, Bu Chang, The Property of A Novel Crosslinked Foam from Thermoplastic Phenol‐Terminated Polyphenylene Ether Resin with High Molecular Weight (MPF) Cured by Hydroxymethylated Phenol‐Terminated Polyphenylene Ether Resin with Low Molecular Weight (LPR), Macromolecular Chemistry and Physics, 5th October 2023,(https://onlinelibrary.wiley.com/doi/10.1002/macp.202300247).The above article, published online on 5th October 2023, on Wiley Online Library (https://doi.org/10.1002/macp.202300247), has been withdrawn by agreement between the journal Editor in Chief, Mara Staffilani, and Wiley‐VCH GmbH, Weinheim. The withdrawal has been agreed because the authors did not respond to requests to finalize their article for publication in the journal as the Version of Record.
Additive Effect of Graphene and Lignin‐Derived Graphene on Radical Polymerization Behaviors of Methacrylate Monomers
Authors: Okamoto Shusuke , Fukuda Mami , Kawabata Koki , Komoda Ayumi , Suwaki Ryo , Mori Mikaru , Fujishiro Fumito , Ishii Takafumi , Mori Masanobu , Nagai Daisuke 
Published: October 2023

AbstractRadical polymerizations of methyl methacrylate (MMA) using graphene or lignin‐derived graphene as additives give the corresponding poly(MMA)s of which much wider molecular weight distribution (MWD) than that of the poly(MMA) without additives. The MWD of the resulting poly(MMA) using graphene is wider compared to that using lignin‐derived graphene, suggesting that the structural differences between the two graphene compounds affect radical polymerization behavior. Furthermore, the radical polymerizations of methacrylate monomers with different substituents using the two graphene compounds are performed, leading to the additive effect of the two graphene compounds which is relevant to the steric hindrance of the monomer.
Stability of Quadruple Hydrogen Bonds in an Ionic Liquid Environment
Authors: Li Chenming , Bhandary Rajesh , Marinow Anja , Bachmann Stephanie , Pöppler Ann‐Christin , Binder Wolfgang H. 
Published: October 2023

AbstractHydrogen bonds (H‐bonds) are highly sensitive to the surrounding environments owing to their dipolar nature, with polar solvents kown to significantly weaken H‐bonds. Herein, the stability of the H‐bonding motif ureidopyrimidinone (UPy) is investigated, embedded into a highly polar polymeric ionic liquid (PIL) consisting of pendant pyrrolidinium bis(trifluoromethylsulfonyl)imide (IL) moieties, to study the influence of such ionic environments on the UPy H‐bonds. The content of the surrounding IL is changed by addition of an additional low molecular weight IL to further boost the IL content around the UPy moieties in molar ratios of UPy/IL ranging from 1/4 up to 1/113, thereby promoting the polar microenvironment around the UPy‐H‐bonds. Variable‐temperature solid‐state MAS NMR spectroscopy and FT‐IR spectroscopy demonstrate that the UPy H‐bonds are largely present as (UPy‐) dimers, but sensitive to elevated temperatures (>70 °C). Subsequent rheology and DSC studies reveal that the ILs only solvate the polymeric chains but do not interfere with the UPy‐dimer H‐bonds, thus accounting for their high stability and applicability in many material systems.
Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T
Authors: Adamson Philip M. , Datta Keshav , Watkins Ron , Recht Lawrence D. , Hurd Ralph E. , Spielman Daniel M. 
Published: October 2023

AbstractPurposeTo explore the potential of 3T deuterium metabolic imaging (DMI) using a birdcage 2H radiofrequency (RF) coil in both healthy volunteers and patients with central nervous system (CNS) lesions.MethodsA modified gradient filter, home‐built 2H volume RF coil, and spherical k‐space sampling were employed in a three‐dimensional chemical shift imaging acquisition to obtain high‐quality whole‐brain metabolic images of 2H‐labeled water and glucose metabolic products. These images were acquired in a healthy volunteer and three subjects with CNS lesions of varying pathologies. Hardware and pulse sequence experiments were also conducted to improve the signal‐to‐noise ratio of DMI at 3T.ResultsThe ability to quantify local glucose metabolism in correspondence to anatomical landmarks across patients with varying CNS lesions is demonstrated, and increased lactate is observed in one patient with the most active disease.ConclusionDMI offers the potential to examine metabolic activity in human subjects with CNS lesions with DMI at 3T, promising for the potential of the future clinical translation of this metabolic imaging technique.
Association of baseline physical activity participation with participant characteristics and outcomes following education and exercise‐therapy in people with knee osteoarthritis: A GLA:D® Australia prospective cohort study
Authors: Bell Emily C. , Pazzinatto Marcella F. , Wallis Jason A. , Kemp Joanne L. , Skou Søren T. , O’Halloran Paul , Crossley Kay M. , De Oliveira Silva Danilo , Semciw Adam I. , Dundules Karen , Barton Christian J. 
Published: October 2023

AbstractObjectivesTo investigate whether participants with knee osteoarthritis classified as ‘more’ or ‘less’ physically active at baseline differ in characteristics and/or outcomes at baseline and at 3 and 12 months following the commencement of an education and exercise‐therapy program.MethodsProspective cohort study using the GLA:D® Australia registry. The University of California, Los Angeles Physical Activity Scale (UCLA) participant data dichotomised as ‘more’ (≥7) or ‘less’ active (≤6). Groups were compared using chi‐square (obesity [baseline only], comorbidity prevalence, medication consumption, fear of damage from physical activity); and linear mixed model regression (12‐item Injury Osteoarthritis Outcome Score [KOOS‐12], pain [visual analogue scale], health‐related quality of life [QoL] [EQ‐5D‐5L]) statistics, adjusted for age, sex and baseline physical activity at 3 and 12 months.ResultsWe included 1059 participants (70% female). At baseline, 267 (25%) were classified as ‘more’ active, increasing to 29% and 30% at 3 and 12 months, respectively. At baseline, compared to the ‘less’ active group, the ‘more’ active group had a lower proportion of participants who were obese (‘more’ = 21% vs. ‘less’ = 44%), had comorbidities (58% vs. 74%) and consumed medications (71% vs. 85%); lower pain intensity (37 vs. 47); and higher KOOS‐12 (59 vs. 50), and health‐related QoL (0.738 vs. 0.665) scores. When accounting for age, sex and baseline physical activity, improvements seen in knee‐related burden and health‐related QoL were not different between groups at 3 or 12 months. Compared to the ‘less’ active group, the proportion of participants not consuming medication remained higher in the ‘more’ active group at 3 (‘more’ 45% vs. ‘less’ 28%) and 12 months (43% vs. 32%).Conclusion‘More’ active people with knee osteoarthritis were less likely to be obese, had fewer comorbidities, lower medication consumption, knee‐related burden and pain intensity, and higher health‐related QoL than ‘less’ active participants at all timepoints.
Visceral adipose tissue reference data computed for GE HealthCare DXA from the National Health and Nutrition Examination Survey data set
Authors: Bennett Jonathan P. , Quon Brandon K. , Fan Bo , Liu En , Kazemi Leila , Villegas‐Valle Rosa C. , Ahgun Raj , Wu Xian‐pin , Zhou Hou‐De , Lu Ying , Shepherd John A. 
Published: October 2023

AbstractObjectiveThe National Health and Nutrition Examination Survey (NHANES) characterizes body composition representative of the US population using dual‐energy x‐ray absorptiometry (DXA) scans. These population‐level trends of abdominal subcutaneous and visceral adipose tissue (SAT and VAT) are useful for identifying measures associated with increased disease risk. Recently, VAT and SAT data collected by Hologic DXA in NHANES were published online; however, there are known differences in the absolute calibration of DXA systems by make. The purpose of this study was to create reference tables suitable for calculating z scores and percentile values for GE HealthCare (GEHC) DXA systems.MethodsDXA scans were acquired on participants aged 8 to 59 years using Hologic systems. DXA measures were converted to GEHC and described using the least median squares curve fitting method in pediatrics (aged <20 years) and adults (aged 20–59 years).ResultsA total of 11,972 adults and 7298 pediatrics were included for this analysis. Adult and pediatric curves were generated by sex and by ethnicity (non‐Hispanic White, non‐Hispanic Black, Hispanic, Asian, Other) and were derived as a function of age.ConclusionsThese results show the ability to generate VAT and SAT reference data for GEHC systems using Hologic DXA data representative of the US youth and adult population.
On the predictive capabilities of non‐local models for ductile crack propagation under different levels of stress triaxiality
Authors: El Khatib Omar , Pham Rinh‐Dinh , Hütter Geralf , Seupel Andreas , Kiefer Bjoern 
Published: October 2023

AbstractDuctile materials are used in many applications such as hydrogen storage and transport, energy plants and additively manufactured components. High safety standards are vital for such applications, which underline the necessity of thoroughly investigating ductile failure to ensure safety and increase components efficiency. Ductile failure is mainly prompted by the evolution of the so‐called ductile damage, characterized by the nucleation, growth and coalescence of microvoids due to plastic deformation. Moreover, the plastic zones formed at the crack tip of ductile materials exhibit high sensitivity to the stress triaxiality level, which in turn distinctly depends on the geometry of the considered component. The quantification of the stress triaxiality at the crack tip is therefore essential to better understand and predict ductile crack propagation and failure. For that reason, a non‐local ductile damage model is employed in this work to simulate the ductile crack propagation under different stress triaxiality conditions. Different geometries are considered, such as constrained geometries of notched bending specimens and unconstrained geometries of center cracked tension specimens, which characterize the different triaxiality levels. To address the effects of thickness and initial crack length, three‐dimensional geometries are simulated, which account for the out‐of‐plane crack‐tip constraints. Finally, to evaluate the prediction quality of the simulations, corresponding experiments have been carried out and direct comparisons are conducted, with respect to the crack length, ductile crack propagation and resistance curves.
Initial interactions with the FDA on developing a validation dataset as a medical device development tool
Authors: Hart Steven , Garcia Victor , Dudgeon Sarah N , Hanna Matthew G , Li Xiaoxian , Blenman Kim RM , Elfer Katherine , Ly Amy , Salgado Roberto , Saltz Joel , Gupta Rajarsi , Hytopoulos Evangelos , Larsimont Denis , Lennerz Jochen , Gallas Brandon D 
Published: October 2023

AbstractQuantifying tumor‐infiltrating lymphocytes (TILs) in breast cancer tumors is a challenging task for pathologists. With the advent of whole slide imaging that digitizes glass slides, it is possible to apply computational models to quantify TILs for pathologists. Development of computational models requires significant time, expertise, consensus, and investment. To reduce this burden, we are preparing a dataset for developers to validate their models and a proposal to the Medical Device Development Tool (MDDT) program in the Center for Devices and Radiological Health of the U.S. Food and Drug Administration (FDA). If the FDA qualifies the dataset for its submitted context of use, model developers can use it in a regulatory submission within the qualified context of use without additional documentation. Our dataset aims at reducing the regulatory burden placed on developers of models that estimate the density of TILs and will allow head‐to‐head comparison of multiple computational models on the same data. In this paper, we discuss the MDDT preparation and submission process, including the feedback we received from our initial interactions with the FDA and propose how a qualified MDDT validation dataset could be a mechanism for open, fair, and consistent measures of computational model performance. Our experiences will help the community understand what the FDA considers relevant and appropriate (from the perspective of the submitter), at the early stages of the MDDT submission process, for validating stromal TIL density estimation models and other potential computational models. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Delivery of re‐irradiation and complex palliative radiotherapy using proton therapy in pediatric cancer patients
Authors: Berlin Eva , Eisenberg Rachel , Hill‐Kayser Christine , Lustig Robert A. , Kurtz Goldie , Cummings Elizabeth , LaRiviere Michael 
Published: October 2023

AbstractBackgroundThe intent of this study is to characterize indications for pediatric palliative‐intent proton radiation therapy (PIPRT).ProcedureWe retrospectively reviewed patients 21 years and younger who received PIPRT. We defined PIPRT as radiotherapy (RT) aimed to improve cancer‐related symptoms/provide durable local control in the non‐curative setting. Mixed proton/photon plans were included. Adjacent re‐irradiation (reRT) was defined as a reRT volume within the incidental dose cloud of a prior RT target, whereas direct reRT was defined as in‐field overlap with prior RT target. Acute toxicity during RT until first inspection visit was graded according to the Common Terminology Criteria for Adverse Events. The Kaplan–Meier method, measured from last PIPRT fraction, was used to assess progression‐free survival (PFS) and overall survival (OS).ResultsEighteen patients underwent PIPRT between 2014 and 2020. Median age at treatment start was 10 years [2–21]. Median follow‐up was 8.2 months [0–48]. Treatment sites included: brain/spine [10], abdomen/pelvis [3], thorax [3], and head/neck [2]. Indications for palliation included: durable tumor control [18], neurologic symptoms [4], pain [3], airway compromise [2], and great vessel compression [1]. Indications for protons included: reRT [15] (three adjacent, 12 direct), craniospinal irradiation [4], reduction of dose to normal tissues [3]. Sixteen experienced grade (G) 1–2 toxicity; two G3. There were no reports of radionecrosis. Median PFS was 5.3 months [95% confidence interval (CI): 2.7–16.3]. Median OS was 8.3 months [95% CI: 5.5–26.3].ConclusionsThe most common indication for PIPRT was reRT to provide durable tumor control. PIPRT appears to be safe, with no cases of high‐grade toxicity.
The evaluation of antimicrobial stewardship for bacterial meningitis in neonates
Authors: Chen Xinsi , Feng Kun , Zhang Yu , Wang Yongming , Zhao Qianqian , Hu Ya , Liu Kaizhen , Wei Hong , Hua Ziyu 
Published: October 2023

AbstractBacterial meningitis (BM) is potentially life threatening in neonates, but the duration of antibiotic therapy is not well established. We aimed to compare the efficacy and safety among neonates suffering from BM of a relatively shortened duration of antibiotic treatment to the currently recommended course. We did a retrospective cohort study in neonates (gestational age [GA] or corrected GA ≥35 weeks) diagnosed with BM. Neonates in the study group were assigned to withdraw the antibiotics on condition that they were clinically stable after taking sufficient antibiotics with normal serological inflammatory biomarkers, whereas the cerebrospinal fluid (CSF) indicators remain abnormal. Neonates in the control group were treated until both serological and CSF indicators returned to normal as recommended. The incidence of recurrent infection after the discontinuation of antibiotics and adverse drug reactions (ADRs) during hospitalization was measured. A total of 233 neonates were enrolled, of whom 160 were assigned to a shortened antibiotic duration and 73 were treated according to the current guidelines. Twelve patients (7.5%) relapsed in the study group, whereas 4 (5.5%) relapsed in the control group (χ2 = 0.320, p = 0.572). The incidences of ADRs were similar in both groups (p > 0.05). The study indicates that antibiotics might be safely discontinued in neonates (GA ≥35 weeks) diagnosed with BM who are clinically stable or improving after antibiotic treatment and feature normal serological inflammatory markers, no severe complications, and no evidence of systemic infection, even if CSF parameters are not completely normal.