bluuebunny/crossref_metadata_2025_split huggingface dataset:
D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability
Authors: Rona Gergely , Miwatani-Minter Bearach , Zhang Qingyue , Goldberg Hailey V. , Kerzhnerman Marc A. , Howard Jesse B. , Simoneschi Daniele , Lane Ethan , Hobbs John W. , Sassani Elizabeth , Wang Andrew A. , Keegan Sarah , Laverty Daniel J. , Piett Cortt G. , Pongor Lorinc S. , Xu Miranda Li , Andrade Joshua , Thomas Anish , Sicinski Piotr , Askenazi Manor , Ueberheide Beatrix , Fenyö David , Nagel Zachary D. , Pagano Michele 
Published: January 2024

ABSTRACTThe large majority of oxidative DNA lesions occurring in the G1 phase of the cell cycle are repaired by base excision repair (BER) rather than mismatch repair (MMR) to avoid long resections that can lead to genomic instability and cell death. However, the molecular mechanisms dictating pathway choice between MMR and BER have remained unknown. Here, we show that, during G1, D-type cyclins are recruited to sites of oxidative DNA damage in a PCNA- and p21-dependent manner. D-type cyclins shield p21 from its two ubiquitin ligases CRL1SKP2and CRL4CDT2in a CDK4/6-independent manner. In turn, p21 competes through its PCNA-interacting protein degron with MMR components for their binding to PCNA. This inhibits MMR while not affecting BER. At the G1/S transition, the CRL4AMBRA1-dependent degradation of D-type cyclins renders p21 susceptible to proteolysis. These timely degradation events allow the proper binding of MMR proteins to PCNA, enabling the repair of DNA replication errors. Persistent expression of cyclin D1 during S-phase increases the mutational burden and promotes microsatellite instability. Thus, the expression of D-type cyclins inhibits MMR in G1, whereas their degradation is necessary for proper MMR function in S.One-Sentence SummaryTo maintain genome stability, D-type cyclins limit mismatch repair (MMR) in G1, whereas their degradation is necessary for proper MMR function in S phase.
Environmental and molecular control of tissue-specific ionocyte differentiation in zebrafish
Authors: Peloggia Julia , Lush Mark E. , Tsai Ya-Yin , Wood Christopher , Piotrowski Tatjana 
Published: January 2024

SUMMARYOrganisms adjust their physiology to cope with environmental fluctuations and maintain fitness. These adaptations occur via genetic changes over multiple generations or through acclimation, a set of reversible phenotypic changes that confer resilience to the individual. Aquatic organisms are subject to dramatic seasonal fluctuations in water salinity, which can affect the function of lateral line mechanosensory hair cells. To maintain hair cell function when salinity decreases, ion-regulating cells, Neuromast-associated ionocytes (Nm ionocytes), increase in number and invade lateral line neuromasts. How environmental changes trigger this adaptive differentiation of Nm ionocytes and how these cells are specified is still unknown. Here, we identify Nm ionocyte progenitors asfoxi3a/foxi3b-expressing skin cells and show that their differentiation is associated with sequential activation of different Notch pathway components, which control ionocyte survival. We demonstrate that new Nm ionocytes are rapidly specified by absolute salinity levels, independently of stress response pathways. We further show that Nm ionocyte differentiation is selectively triggered by depletion of specific ions, such as Ca2+and Na+/Cl−, but not by low K+levels, and is independent of media osmolarity. Finally, we demonstrate that hair cell activity plays a role in Nm ionocyte recruitment and that systemic factors are not necessary for Nm ionocyte induction. In summary, we have identified how environmental changes activate a signaling cascade that triggers basal skin cell progenitors to differentiate into Nm ionocytes and invade lateral line organs. This adaptive behavior is an example of physiological plasticity that may prove essential for survival in changing climates.
Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction
Authors: Li Xinxing , Liu Tao , Bacchiocchi Antonella , Li Mengxing , Cheng Wen , Wittkop Tobias , Mendez Fernando , Wang Yingyu , Tang Paul , Yao Qianqian , Bosenberg Marcus W. , Sznol Mario , Yan Qin , Faham Malek , Weng Li , Halaban Ruth , Jin Hai , Hu Zhiqian 
Published: January 2024

AbstractWhile whole genome sequencing (WGS) of cell-free DNA (cfDNA) holds enormous promise for molecular residual disease (MRD) detection, its performance is limited by WGS error rate. Here we introduce AccuScan, an efficient cfDNA WGS technology that enables genome-wide error correction at single read level, achieving an error rate of 4.2×10-7, which is about two orders of magnitude lower than a read-centric de-noising method. When applied to MRD detection, AccuScan demonstrated analytical sensitivity down to 10-6circulating tumor allele fraction at 99% sample level specificity. In colorectal cancer, AccuScan showed 90% landmark sensitivity for predicting relapse. It also showed robust MRD performance with esophageal cancer using samples collected as early as 1 week after surgery, and predictive value for immunotherapy monitoring with melanoma patients. Overall, AccuScan provides a highly accurate WGS solution for MRD, empowering circulating tumor DNA detection at parts per million range without high sample input nor personalized reagents.One Sentence SummaryAccuScan showed remarkable ultra-low limit of detection with a short turnaround time, low sample requirement and a simple workflow for MRD detection.
Consumer attitude and behavioural intention towards organic wine: the roles of consumer values and involvement
Authors: Dong Yingying , Gao Lisa 
Published: January 2024

PurposeThis study aims to identify the decision-making process involved in the purchase of organic wine from consumer values to attitudes to behavioural intention towards organic wine via the value–attitude–behaviour (VAB) model. Involvement in wine is also taken into consideration.Design/methodology/approachThe data were collected using a snowball sampling method and a closed-ended questionnaire. A total of 209 responses were analysed. Linear regression and PROCESS Macro on SPSS were used to perform data analysis.FindingsBoth biospheric-altruistic values and egoistic values are positively associated with attitudes towards organic wine. Attitude is found to mediate the relationship between biospheric-altruistic/egoistic values and behavioural intention. Egoistic values are found to significantly predict behavioural intention in the organic wine purchase context. Involvement was found to moderate the relationship between egoistic values and attitudinal loyalty.Originality/valueThis study identifies the decision-making hierarchy from consumer values to attitudes to behavioural intention, theoretically confirming the robustness of the VAB model in the organic wine consumption context. It also makes a practical contribution by indicating the marketing emphasis of organic wine and segmenting potential consumers according to their values and levels of wine involvement.
Who is the next China? Comparative advantage analysis from top ten apparel exporting nations
Authors: Das Sudipta , Hasan Md Rokibul , Das Debanjan 
Published: January 2024

Purpose
This study aims to measure the competitiveness of top apparel exporting nations competing with China in different apparel product categories across the global environment.

Design/methodology/approach
Compound annual growth rate, trade competitiveness, market share percentages, revealed comparative advantage and its variant normalized revealed comparative advantage using two-, four- and six-digit harmonized system codes for the period of 2016–2021 were used to understand the comparative advantage of competing apparel exporting nations.

Findings
The findings revealed that China still holds a more decisive comparative advantage than its competitors over the majority of the product categories within the knitted or not knitted apparel and clothing accessories. The other competing nations hold better export competitiveness over China in specific categories. However, that is not sufficient to be the “Next China.”

Research limitations/implications
The study has important implications for different stakeholders of the global apparel industry, such as governments, industry officials, policymakers, investors, researchers and students. The study’s limitations arise from using product categories as competitiveness indicators, notably relying on a macro level approach for measurement while the micro level perspective is not analyzed, which constitutes a significant limitation of the study.

Originality/value
This research thoroughly analyzes the competitive position of the top ten apparel-exporting countries in the global market.
How customer knowledge management helps retain fitness club members: a mediating effect of relationship quality
Authors: Ng Kenneth Shiu Pong , Feng Yan , Lai Ivan Ka Wai , Yang Lois Zi-Yu 
Published: January 2024

PurposeThis study aims to develop a conceptual model to understand how customer knowledge management (CKM) affects fitness club membership renewal through the mediation of relationship quality.Design/methodology/approachData were collected outside of fitness clubs using a systematic sampling method. A total of 224 valid responses were collected. Structural equation modelling was used to evaluate the relationship between the constructs of the research model.FindingsThe results indicate that both knowledge from customers and knowledge for customers have a positive influence on customer satisfaction and customer trust. Among them, knowledge for customers has a stronger influence on customer satisfaction while knowledge from customers has a greater influence on customer trust. Additionally, three dimensions of relationship quality (customer satisfaction, customer trust and customer commitment) positively influence membership renewal intention with customer commitment exhibiting the greatest influence on it.Originality/valueThis study combines the theories of CKM and relationship quality management to explain why members will renew their service contracts. By using fitness clubs as an example, this research extends the authors' understanding of how knowledge from and for customers can influence customers' attitudes and behavioural intentions towards service companies.
DeFi era: the behavioral intentions toward cryptocurrency in Lebanon
Authors: Abou Ali Ali Abdel Karim 
Published: January 2024

PurposeThis paper examines the factors which impact the behavioral intentions toward cryptocurrency based on signaling theory.Design/methodology/approachData were collected through online questionnaire, and responses from 223 individuals in Lebanon were analyzed through SEM technique using Amos 24.FindingsThe outcomes portrayed the positive effect of perceived benefits and trust in cryptocurrency on behavioral intentions toward cryptocurrency; while not supporting the hypothesized influence of herd behavior and regulatory support.Originality/valueThis paper is among the first studies to adopt Signaling Theory (ST) in the cryptocurrency behavioral intentions research. Moreover, it is of the initial efforts in Lebanon and Middle East in evaluating behavioral intentions to use cryptocurrency, and it provide insights for future researchers, crypto project owners, crypto investors and crypto trading platforms.
Online privacy literacy and users' information privacy empowerment: the case of GDPR in Europe
Authors: Prince Christine , Omrani Nessrine , Schiavone Francesco 
Published: January 2024

PurposeResearch on online user privacy shows that empirical evidence on how privacy literacy relates to users' information privacy empowerment is missing. To fill this gap, this paper investigated the respective influence of two primary dimensions of online privacy literacy – namely declarative and procedural knowledge – on online users' information privacy empowerment.Design/methodology/approachAn empirical analysis is conducted using a dataset collected in Europe. This survey was conducted in 2019 among 27,524 representative respondents of the European population.FindingsThe main results show that users' procedural knowledge is positively linked to users' privacy empowerment. The relationship between users' declarative knowledge and users' privacy empowerment is partially supported. While greater awareness about firms and organizations practices in terms of data collections and further uses conditions was found to be significantly associated with increased users' privacy empowerment, unpredictably, results revealed that the awareness about the GDPR and user’s privacy empowerment are negatively associated. The empirical findings reveal also that greater online privacy literacy is associated with heightened users' information privacy empowerment.Originality/valueWhile few advanced studies made systematic efforts to measure changes occurred on websites since the GDPR enforcement, it remains unclear, however, how individuals perceive, understand and apply the GDPR rights/guarantees and their likelihood to strengthen users' information privacy control. Therefore, this paper contributes empirically to understanding how online users' privacy literacy shaped by both users' declarative and procedural knowledge is likely to affect users' information privacy empowerment. The study empirically investigates the effectiveness of the GDPR in raising users' information privacy empowerment from user-based perspective. Results stress the importance of greater transparency of data tracking and processing decisions made by online businesses and services to strengthen users' control over information privacy. Study findings also put emphasis on the crucial need for more educational efforts to raise users' awareness about the GDPR rights/guarantees related to data protection. Empirical findings also show that users who are more likely to adopt self-protective approaches to reinforce personal data privacy are more likely to perceive greater control over personal data. A broad implication of this finding for practitioners and E-businesses stresses the need for empowering users with adequate privacy protection tools to ensure more confidential transactions.
Inflation–inequality puzzle: is it still apparent?
Authors: Berisha Edmond , Gupta Rangan , Gharehgozli Orkideh 
Published: January 2024

PurposeThe primary focus of this study is to examine the distributional consequences of the widespread increase in prices. The fundamental question the study aims to address is whether the dynamics of income distribution due to higher inflation differ in the short term compared to the long run.Design/methodology/approachThe authors estimated a panel-data model (fixed effects) using inequality and inflation data available at a high frequency, i.e. on a quarterly basis for over 30 years, and found evidence that inflation causes rapid swings in income distribution.Findings The authors’ contribution to the literature lies in providing evidence that inflation rapidly causes swings in income distribution, even after controlling for the state of the economy. The authors also demonstrate that the magnitude and direction of the effect of inflation on income inequality depend on whether the initial inflation rate is below or above the Federal Reserve’s target of 2%.Originality/valueTo the best of the authors’ knowledge, the authors are the first to emphasize that the targets set by central banks can drive the strength and direction of the relationship between inflation and income inequality.
Research on the evolution and determinants of knowledge transfer network in patent-intensive industries
Authors: Li Jianguo , Gong Yuwen , Li Hong 
Published: January 2024

PurposeThis study aims to investigate the structural characteristics, spatial evolution paths and internal driving mechanisms of the knowledge transfer (KT) network in China’s patent-intensive industries (PIIs). The authors' goal is to provide valuable insights to inform policy-making that fosters the development of relevant industries. The authors also aim to offer a fresh perspective for future spatiotemporal studies on industrial KT and innovation networks.Design/methodology/approachIn this study, the authors analyze the patent transfer (PT) data of listed companies in China’s information and communication technology (ICT) industry, spanning from 2010 to 2021. The authors use social network analysis and the quadratic assignment procedure (QAP) method to explore the problem of China’s PIIs KT from the perspectives of technical characteristics evolution, network and spatial evolution and internal driving mechanisms.FindingsThe results indicate that the knowledge fields involved in the PT of China’s ICT industry primarily focus on digital information transmission technology. From 2010 to 2021, the scale of the ICT industry’s KT network expanded rapidly. However, the polarization of industrial knowledge distribution is becoming more serious. QAP regression analysis shows that economic proximity and geographical proximity do not affect KT activities. The similarity of knowledge application capacity, innovation capacity and technology demand categories in various regions has a certain degree of impact on KT in the ICT industry.Originality/valueThe current research on PIIs mainly focuses on measuring economic contributions and innovation efficiency, but less on KT in PIIs. This study explores KT in PIIs from the perspectives of technological characteristics, network and spatial evolution. The authors propose a theoretical framework to understand the internal driving mechanisms of industrial KT networks.
Online bubbles and echo chambers as social systems
Authors: Palmieri Emerson 
Published: January 2024

PurposeThe aim of the text is to reflect on the formation of the so-called digital echo chambers or filter bubbles, which are environments formed around particular topics whose objective is to promote a given political-ideological position. The argument the author puts forward is that echo chambers are social systems of interaction created to deal with the process of informational overload brought about by the consolidation of digital media in people’s daily lives.Design/methodology/approachThe author used Niklas Luhmann’s theory of social systems to explain what the author is calling social systems of interaction. Furthermore, the author made clarifications about: (1) the current debate regarding echo chambers; (2) what is the concept of “information” that the author is using to formulate the proposition and (3) what is the specificity that digital media bring when the author talks about informational overload and about the formation of echo chambers.FindingsThe author concluded that echo chambers can be seen as digital interaction systems, but the concept of “interaction” must be adapted. The author also concluded that echo chambers help society to deal with the phenomenon of informational overload.Originality/valueThere are few works which try to make a detailed analysis of echo chambers from a Luhmannian perspective. With the propositions presented in this text, along with other writings of the own, the author gives an important step in that direction by introducing the topic in the social systems researchers community.
The role of technology in entrepreneurship: a comprehensive systematic and bibliometric analysis
Authors: Jayanna Usha Rani , Jaya Prakash Senthil Kumar , Aluvala Ravi , Venkata Rao B. 
Published: January 2024

PurposeThrough bibliometric analysis, the study intends to reveal the evolution of the trends in the Scopus database, the scope of research and the connection between technology and entrepreneurship.Design/methodology/approachThis study uses a comprehensive science mapping approach, integrating network visualisation to map research groups, bibliometric analysis to measure publication trends and thematic analysis to identify overarching themes. This study uses a thorough technique to examine the complex interaction between technology and entrepreneurship from 2000 to 2023. The collection includes information from various sources, creating a corpus of 2,207 documents. These sources include 698 scholarly journals, books and other publications.FindingsAccording to the report, the interest in technology and entrepreneurship is expanding. The three nations conducting the most study on this subject is the USA, the UK and Italy. Some of the top writers in this area include James A. Cunningham, Alison N. Link and David B. Audretsch.Research limitations/implicationsThe study found possibilities and problems associated with the interaction between technology and entrepreneurship. Additionally, the study found several research holes in this area. The study also noted some research gaps in this field, including those related to the sustainability of society and the environment, the effects of entrepreneurship on inequality and the difficulties faced by entrepreneurs in underdeveloped nations.Practical implicationsThis study thoroughly overviews the business and technology sectors. It outlines some of the difficulties that must be overcome whilst identifying the main research trends in this field. Researchers, decision-makers and businesspeople interested in using technology for entrepreneurial endeavours can all benefit from the study’s findings.Social implicationsThis study’s dataset’s scope, which might not include all pertinent publications, is one of its limitations. Nevertheless, the results add to a thorough picture of the state of the profession and recent developments. This study’s insights are valuable for researchers, policymakers and entrepreneurs interested in leveraging technology for entrepreneurial pursuits.Originality/valueThe research points to a number of directions that need more inquiry, such as in-depth studies into the social and environmental implications of technology-driven entrepreneurship and methods to combat inequality.
Urban planning education in the global south: exploring the possibilities for Egyptian curricula
Authors: Maged Ola Ahmed , Brown Robert , Abdel-Moneim Nancy 
Published: January 2024

PurposeThe purpose of the research is to propose reforms that would help to bridge the gap between theory and practice and produce more effective urban planners. The research on urban planning curricula in the global South is a valuable contribution to the field of urban planning education. It provides a new perspective on the challenges facing urban planning education in these countries and offers a roadmap for improvement.Design/methodology/approachThe research explores and evaluates the urban planning curricula in the global South, with a particular interest in Egypt. The research employs the use of questionnaires with 56 university instructors, analysed thematically, to evaluate the current content of curricula. The results are compared and correlated with a pilot study exploring research interest, government policies and practices of urban planning in Egypt.FindingsThrough comparing the results of the evaluation with the current research interest in urban planning in Egypt, the paper investigates the possibility of improving current educational curricula using comparative network analysis which would establish stronger interdisciplinary connections.Originality/valueThe seeming disconnects between urbanism concepts taught in educational curricula and their relevance in practice and reality is a vital issue in urban studies and planning. Interdisciplinary connections with topics like politics, economies, gender, and others can assist curricula in becoming more relevant to real-world situations. This disconnect is even more apparent in the global South where most educational content is highly derivative from Northern contexts. Though such interdisciplinary aspects are under discussed in educational curricula, they are frequently discussed in academic research.