bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Nanoparticles Based on Alendronate Polyethylene Glycol Conjugated Chitosan for the Delivery of siRNA and Curcumin for Bone Metastasized Breast Cancer Applications
Authors: Mushtaq Asim , Li Li , Grøndahl Lisbeth , A Anitha 
Published: October 2023

AbstractBone metastasized breast cancer reduces the quality of life and median survival. Targeted delivery of small interfering RNA (siRNA) and chemotherapeutic drugs using nanoparticles (NPs) is a promising strategy to overcome current limitations in treating these metastatic breast cancers. This research develops alendronate conjugated polyethylene glycol functionalized chitosan (ALD‐PEG‐CHI) NP for the delivery of cell death siRNA (CD‐siRNA) and curcumin (CUR) and explores its targeting ability and in vitro cell cytotoxicity. Polyethylene glycol functionalized CHI (mPEG‐CHI) NPs serve as control. The size of CD‐siRNA loaded NPs is below 100 nm while CUR loaded NPs is below 200 nm, with near neutral zeta potential for all NPs. The CUR encapsulation efficiency (EE) is 70% and 88% for targeted and control NPs, respectively, while complete encapsulation of CD‐siRNA is achieved in both NP systems. The bone targeting ability of CY5‐dsDNA loaded ALD‐PEG‐CHI NPs using hydroxyapatite discs is fivefold compared to control indicating ALD presentation at the targeting NP surface. Delivery of CD‐siRNA loaded NPs and CUR loaded NPs show synergistic and additive growth inhibition effects against MCF‐7 cells by mPEG‐CHI and ALD‐PEG‐CHI NPs, respectively. Overall, these in vitro results illustrate the potential of the targeted NPs as an effective therapeutic system toward bone metastasized breast cancer.
Gradient Biomolecular Immobilization of 3D Structured Poly‐ɛ‐caprolactone Biomaterials toward Functional Engineered Tissue
Authors: Zaeri Ahmadreza , Zgeib Ralf , Zhang Fucheng , Cao Kai , Chang Robert C. 
Published: October 2023

AbstractAdditive manufacturing (AM) enables the tailored production of precision fibrous scaffolds toward various engineered tissue models. Moreover, by functionalizing scaffolds in either a uniform or gradient pattern of biomolecules, different target tissues can be fabricated in vitro to capture key characteristics of in vivo cellular microenvironments. However, current engineered tissue models lack the appropriate cellular cues that are needed to deterministically direct cell behavior. Specifically, tunable and reproducible scaffold‐guided stimuli are identified herein as the missing link between biomaterial structure and cellular behavior. Therefore, the bottleneck of precision control is addressed here over the immobilization of patterned biomolecular stimuli with either uniform or gradient distribution over the AM‐enabled 3D biomaterial model as a function of different growth factors exposure variables, protocols, and various scaffold architectural design parameters. The produced study outcomes herein will improve the directing and guiding of biological cell attachment and growth direction in the context of scaffold‐guided stimuli techniques. Therefore, unprecedented control is presented here over 3D structured biomaterial gradient functionalization and immobilization of biomolecules toward biomimetic tissue architectures.
When perceived physician burnout leads to family burnout: How secondary emotional trauma impacts physician spouses
Authors: Grimmer Sarah A. , Jacquin Kristine M. 
Published: October 2023

AbstractThis study investigated the effect of perceived physician burnout on psychological distress (anxiety, depression, and secondary traumatic stress) in physician spouses. Two‐hundred and three physician spouses participated in the study between April and May 2021. Physician spouses completed a burnout measure on behalf of their physician partner, and psychological distress measures for themselves. Results showed perceived physician burnout was positively correlated with anxiety (r = 0.24), depression (r = 0.13), and secondary traumatic stress (r = 0.14) in physician spouses. A covariate analysis including eight demographic variables did not significantly contribute to the relationship between perceived physician burnout and psychological distress in physician spouses. Moderation analyses showed no significant interactions when the personality trait agreeableness, total score on a resiliency questionnaire, and compassion fatigue were included as moderators in the relationship between perceived physician burnout and psychological distress in physician spouses. These findings indicate that physician spouses experience secondary psychological distress when they believe their partner (the physician) is experiencing burnout, emphasizing the need for mental health support during medical training.
Bilateral gluteal reconstruction with deep inferior epigastric perforator flaps and saphenofemoral arteriovenous loops
Authors: McGraw J. Reed , Jaimez Ivan A. , Card Elizabeth , Holland Michael , Azoury Saïd C. , Kovach Stephen J. 
Published: October 2023

AbstractThe use of liquid silicone injections for soft tissue augmentation harbors numerous risks and is not approved by the FDA. Still, such injections are frequently performed by unlicensed providers, often in the gluteal region, and can lead to infection, soft‐tissue breakdown, scarring, and disfigurement. The purpose of this case report was to demonstrate the use of immediate, abdominally based free flaps for reconstruction in a patient with bilateral total gluteal defects and limited inflow options in the setting of remote silicone injections. The patient is a 45‐year‐old female who developed chronically infected injected silicone in the bilateral buttocks leading to draining abscesses and soft tissue breakdown. The patient required radical debridement and excision of the bilateral buttocks to remove all foreign material. After intermediate skin grafting of the residual wounds, the patient then was deemed a candidate for bilateral free flap reconstruction of the buttocks. On exploration of the bilateral defects, both 20 cm × 10 cm in size, the gluteal vessels were non‐usable, and preoperative CTA additionally had revealed no suitable posteriorly based perforators. Therefore, bilateral arteriovenous (AV) loops, measuring 30 cm in length, were then constructed utilizing the greater saphenous veins anastomosed to the femoral arteries which were then tunneled to the defect. The soft tissue defects were concurrently reconstructed with bilateral deep inferior epigastric perforator (DIEP) flaps measuring 16 cm × 12 cm. The postoperative course was complicated by small seromas in each groin requiring drain placement by interventional radiology on postoperative day 16. Otherwise, the patient's buttocks healed well, and functionally, the patient had regained the ability to sit and was satisfied with the aesthetic appearance of the reconstruction as of last follow‐up at 10 months. Abdominally based free flap reconstruction with AV loops, in this case, provided for successful reconstruction of otherwise challenging soft‐tissue defects with limited inflow options.
Retracted: Resveratrol Derivative, Trans‐3, 5, 4′‐Trimethoxystilbene, Prevents the Developing of Atherosclerotic Lesions and Attenuates Cholesterol Accumulation in Macrophage Foam Cells
Authors: Hong Ming , Li Jinke , Li Siying , Almutairi Mohammed M. 
Published: October 2023

AbstractMol. Nutr. Food Res.2020, 64, 1 901 115https://doi.org/10.1002/mnfr.201901115.The above article, published online on 22 January 2020, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editor‐in‐Chief, Dr. Julia Reuter, and Wiley‐VCH GmbH. Following publication, the journal was contacted by the University of Kansas who indicated that three of the co‐authors, Jinke Li, Siying Li and Mohammed M. Almutairi, whose affiliations had been noted at the Department of Pharmacology & Toxicology, University of Kansas, were not affiliated with the university. In addition, the journal was made aware of concerns raised by third parties regarding this article which evidences image duplication between Figures 1, 2, 3, 4, 6, and 7, and Table 1 in this article and two other articles purporting to show different data. The authors were contacted to ask for their explanation of the concerns raised, but no response was received. The retraction has been agreed as the editorial team no longer have confidence in the reported results and conclusions given the significant overlap between the results reported in the Figures and other published articles.
Children at high familial risk for obesity show executive functioning deficits prior to development of excess weight status
Authors: Pearce Alaina L. , Hallisky Kyle , Rolls Barbara J. , Wilson Stephen J. , Rose Emma , Geier Charles F. , Garavan Hugh , Keller Kathleen L. 
Published: October 2023

AbstractObjectiveThe objective of this study was to determine whether children with healthy weight who vary by familial risk for obesity differ in executive functioning.MethodsChildren (age 7–8 years) without obesity (n = 93, 52% male) who differed by familial risk for obesity (based on maternal weight status) completed go/no‐go and stop‐signal tasks to assess inhibitory control and an N‐back task to assess working memory. Dual energy x‐ray absorptiometry measured adiposity. Linear and mixed‐effect models assessed unique effects and relative importance analysis‐quantified relative effects of familial risk and percent body fat.ResultsChildren at high compared with low familial risk showed worse inhibitory control; however, child adiposity was not associated with inhibitory control. Both high familial risk and greater child adiposity were associated with worse N‐back performance when cognitive demand was high (2‐back), but not low (0‐ and 1‐back). The relative effect of familial risk on executive functioning was 2.7 to 16 times greater than the relative effect of percent body fat.ConclusionsThese findings provide initial evidence that deficits in executive functioning may precede the development of obesity in children at high familial risk for this disease. Additional family risk studies are needed to elucidate the pathways through which maternal obesity influences child executive functioning and risk for obesity.
Identification of creep parameters from multi‐step relaxation tests on miniaturised specimen
Authors: Schirmer Richard Wolfgang , Selent Marcel , Abendroth Martin , Kiefer Bjoern 
Published: October 2023

AbstractThe small punch test (SPT) is a miniaturised method for thermo‐mechanical materials testing. The combination of simple specimen geometry and low required specimen volume is ideal for minimally invasive characterisation and monitoring of the current material condition in technological systems, including nuclear plants.The aim of the present study is to identify creep material properties of the chromium steel P91 (X10CrMoVNb9‐1) via small punch testing. It is examined to which extent a single relaxation test is suitable to replace several creep tests at different force levels. The inverse parameter identification method utilises a non‐linear optimisation approach in order to match the results of simulation and experiment. The simulation is performed using finite element analysis (FEA) and the considered material law aims to represent the high‐temperature behaviour of steels. To this end, a modified Liu–Murakami model is specifically used along with linear elasticity and non‐linear isotropic plasticity. We propose a strategy, that can be used to separately identify the Norton‐parameters from multi‐step relaxation tests performed on one specimen. Thereby, the applied strain (displacement, if utilising SPT) is kept constant after initial loading, which enables stress relaxation within the specimen. In case of the SPT, this behaviour yields a decreasing reaction force which approximately approaches a constant value. During the repeated loading phases, specimen failure may occur, due to further plastification of the specimen. Loading and relaxation cycles are repeated until specimen failure.The identified parameters are validated via small punch creep experiments at different force levels. It will be shown that good agreement is observed when comparing the sets of identified parameters.
Metal–organic framework derived N‐doped zinc oxide carbon nanocomposites for catalytic removal of dye and formaldehyde
Authors: Zou Jing , Tang Xiaoning , He Li , Jin Wanhui , Yu Qian , Yu Jing , Sun Lei , Cai Guangming , Wang Xin , Cheng Deshan 
Published: October 2023

AbstractBiomass‐based catalysis has drawn a gradually increased attention due to its eco‐friendliness, cost‐effective, and good reusability. In this work, a novel metal–organic framework (MOF) derived nitrogen‐doped zinc oxide carbon (ZnO/N/C) nanocomposites were synthesized on pine cone by solvothermal and carbonization method. Scanning electron microscopy, x‐ray diffractometer, and x‐ray photoelectron spectroscopy were employed to confirm the presence of N‐doped ZnO rod‐like nanostructures on the as‐prepared composites. The obtained ZnO/N/C nanocomposites were employed as catalytic materials for the decomposition of methylene blue (MB) dye and adsorption of formaldehyde (HCHO). The ZnO/N/C nanocomposites can degrade more than 90% of the MB solution within 90 min under visible light irradiation, besides, they can rapidly absorb and decompose HCHO. The high‐catalytic performance of ZnO/N/C nanocomposites can be attributed to the high‐superficial area of ZIF‐8, the carbonization that ensures the high conductivity and high‐slight absorption of carbon skeleton materials, and the accelerated transfer of photogenerated electrons. This simple and green preparation method has promoted the sustainable utilization of biomass resources with great significance for application of carbon‐based porous materials in catalytic field.Highlights
MOF derived ZnO/N‐doped carbon nanocomposites were successfully synthesized.
Presence of N‐doped ZnO rod‐like nanostructures on carbon nanocomposites.
ZnO/N/C nanocomposites could be used as a catalyst for MB photodegradation.
ZnO/N/C nanocomposites can be readily absorption and decompose of HCHO.
Impact on generation and recombination rate in Cu2ZnSnS4 (CZTS) solar cell for Ag2S and In2Se3 buffer layers with CuSbS2 back surface field layer
Authors: Chauhan Pratibha , Agarwal Surbhi , Srivastava Vaibhava , Maurya Sadanand , Hossain M. Khalid , Madan Jaya , Yadav Rajesh Kumar , Lohia Pooja , Dwivedi Dilip Kumar , Alothman Asma A. 
Published: October 2023

AbstractFor photovoltaic (PV) applications, the earth‐abundant and non‐hazardous Kesterite Cu2ZnSnS4 (CZTS) is a possible substitute for chalcopyrite copper indium gallium selenide (CIGS). This research offers insight into the most innovative method for improving the performance of Kesterite solar cells (SCs) by using CuSbS2 back surface field (BSF) and Ag2S and In2Se3 as buffer layers, focuses on aligning energy bands, reducing non‐radiative recombination, and improving open‐circuit voltage (Voc). The proposed cells are Ni/CuSbS2/CZTS/In2Se3/ITO/Al and Ni/CuSbS2/CZTS/Ag2S/ITO/Al by adding interfaces. The optimized CZTS SCs with In2Se3 achieve a short‐circuit current density (Jsc) of 30.274 mA/cm2, fill factor (FF) of 89.15%, power conversion efficiency (PCE) of 31.67%, and Voc of 1.173 V. With the Ag2S buffer layer, PCE is 31.02%, FF is 88.61%, Jsc is 30.245 mA/cm2, and Voc is 1.157 V. These results depict the potential of CZTS‐based SCs with improved performance compared with conventional structures.
Education‐related needs for children with cystic fibrosis: Perspectives of US pediatric care teams
Authors: Hjelm Michelle , Hente Elizabeth , Schuler Christine L. , Duan Qing , Strong Sarah , Boat Thomas , Filigno Stephanie 
Published: October 2023

AbstractObjectivePatients with cystic fibrosis (CF) often bring education‐related concerns to their medical teams. Concerns around the ability for CF care teams to identify and address these concerns exist. We sought to describe CF care team perceptions of (1) patient and family education‐related needs, (2) how these needs are identified, documented and addressed, and (3) education‐related resource gaps.MethodsA survey was emailed to pediatric care teams in the CF Foundation Care Center Network in April 2022. Individuals or care teams could complete the survey. Responses were aggregated for descriptive analysis.ResultsSixty‐seven programs responded representing 52% of United States pediatric CF centers. Most centers (88%) indicated social workers primarily address school concerns. Care teams often complete school forms (99%), coach families to communicate with schools (96%), communicate with schools directly (90%), and develop educational plans (76%). Formal education risk assessment and support programs are relatively uncommon (19%). Common student‐specific needs include carrying medications (75%) and leaving class for gastrointestinal issues (54%). Needs reported are informational materials for families and schools (94%), staff education about school concerns and how to address them (91%), additional staff for education‐related issues (65%), and expertise in education plan development (62%).ConclusionCF care teams often lack comprehensive resources to identify and address education‐related concerns. Systematically performing needs assessments, improving training for providers, and evaluating the benefits of education specialists on care teams may better identify and address education‐related needs. Supporting educational progression will foster continued independence and well‐being in adulthood.
Frequency and burden of disease for SARS‐CoV‐2 and other viral respiratory tract infections in children under the age of 2 months
Authors: Latouche Marie , Ouafi Mahdi , Engelmann Ilka , Becquart Adrien , Alidjinou Enagnon Kazali , Mitha Ayoub , Dubos François 
Published: October 2023

AbstractObjectiveTo evaluate the frequency and burden of disease of SARS‐CoV‐2 and other respiratory viruses in children under the age of 2 months.MethodsA retrospective, cross‐sectional, single‐center study was conducted between March 2021 and February 2022. All children under the age of 2 months and tested for SARS‐CoV‐2 were included. The frequency of SARS‐CoV‐2, of other respiratory viruses and the burden of disease caused by SARS‐CoV‐2 and other respiratory viruses were evaluated.ResultsSeven hundred and twenty‐seven children with an RT‐PCR test for SARS‐CoV‐2 were included (mean age: 0.9 months (±0.6); boys: 57%); 514 (71%) in the emergency room and 213 (29%) in hospital. Among them, 62 (8.5%) had a positive RT‐PCR test for SARS‐CoV‐2, more often in the Omicron period (23%) than in the Alpha period (4%). Of the 565 (78%) with a multiplex RT‐PCR test for other viruses, 325 (58%) were positive. Children with a positive SARS‐CoV‐2 were less likely to have required respiratory support (p = 0.001), enteral nutrition (p = 0.03), or intensive care admission (p = 0.01) and had a shorter hospital stay than children with other respiratory viruses (5 days vs. 7 days, p = 0.007).ConclusionIn this young population of children, SARS‐CoV‐2 infection was less frequent and less severe than other viral respiratory infections.
Applied physiologically‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat
Authors: Frechen Sebastian , Ince Ibrahim , Dallmann André , Gerisch Michael , Jungmann Natalia A. , Becker Corina , Lobmeyer Maximilian , Trujillo Maria E. , Xu Shiyao , Burghaus Rolf , Meyer Michaela 
Published: October 2023

AbstractVericiguat (Verquvo; US: Merck, other countries: Bayer) is a novel drug for the treatment of chronic heart failure. Preclinical studies have demonstrated that the primary route of metabolism for vericiguat is glucuronidation, mainly catalyzed by uridine diphosphate‐glucuronosyltransferase (UGT)1A9 and to a lesser extent UGT1A1. Whereas a drug–drug interaction (DDI) study of the UGT1A9 inhibitor mefenamic acid showed a 20% exposure increase, the effect of UGT1A1 inhibitors has not been assessed clinically. This modeling study describes a physiologically‐based pharmacokinetic (PBPK) approach to complement the clinical DDI liability assessment and support prescription labeling. A PBPK model of vericiguat was developed based on in vitro and clinical data, verified against data from the mefenamic acid DDI study, and applied to assess the UGT1A1 DDI liability by running an in silico DDI study with the UGT1A1 inhibitor atazanavir. A minor effect with an area under the plasma concentration‐time curve (AUC) ratio of 1.12 and a peak plasma concentration ratio of 1.04 was predicted, which indicates that there is no clinically relevant DDI interaction anticipated. Additionally, the effect of potential genetic polymorphisms of UGT1A1 and UGT1A9 was evaluated, which showed that an average modest increase of up to 1.7‐fold in AUC may be expected in the case of concomitantly reduced UGT1A1 and UGT1A9 activity for subpopulations expressing non‐wild‐type variants for both isoforms. This study is a first cornerstone to qualify the PK‐Sim platform for use of UGT‐mediated DDI predictions, including PBPK models of perpetrators, such as mefenamic acid and atazanavir, and sensitive UGT substrates, such as dapagliflozin and raltegravir.
Deciphering resveratrol's role in modulating pathological pain: From molecular mechanisms to clinical relevance
Authors: Wang Biao , Jiang Hai‐Mei , Qi Lu‐Ming , Li Xiang , Huang Qun , Xie Xin , Xia Qing 
Published: October 2023

AbstractPathological pain, a multifaceted and debilitating ailment originating from injury or post‐injury inflammation of the somatosensory system, poses a global health challenge. Despite its ubiquity, reliable therapeutic strategies remain elusive. To solve this problem, resveratrol, a naturally occurring nonflavonoid polyphenol, has emerged as a potential beacon of hope owing to its anti‐inflammatory, antioxidant, and immunomodulatory capabilities. These properties potentially position resveratrol as an efficacious candidate for the management of pathological pain. This concise review summaries current experimental and clinical findings to underscore the therapeutic potential of resveratrol in pathological pain, casting light on the complex underlying pathophysiology. Our exploration suggests that resveratrol may exert its analgesic effect by the modulating pivotal signaling pathways, including PI3K/Akt/mTOR, TNFR1/NF‐κB, MAPKs, and Nrf2. Moreover, resveratrol appears to attenuate spinal microglia activation, regulate primary receptors in dorsal root sensory neurons, inhibit pertinent voltage‐gated ion channels, and curb the expression of inflammatory mediators and oxidative stress responses. The objective of this review is to encapsulate the pharmacological activity of resveratrol, including its probable signaling pathways, pharmacokinetics, and toxicology pertinent to the treatment of pathological pain. Hopefully, we aim to map out promising trajectories for the development of resveratrol as a potential analgesic.
Two‐Mode Correlated Multiphoton Bundle Emission
Authors: Wang Yi , Zou Fen , Liao Jie‐Qiao 
Published: October 2023

AbstractThe preparation of correlated multiphoton sources is an important research topic in quantum optics and quantum information science. Here, two‐mode correlated multiphoton bundle emission in a nondegenerate multiphoton Jaynes–Cummings model, which is comprised of a two‐level system coupled with two cavity modes is studied. The two‐level system is driven by a near‐resonant strong laser such that the Mollow regime dominates the physical processes in this system. Under certain resonance conditions, a perfect super‐Rabi oscillation between the zero‐photon state and the ()‐photon state of the two cavity modes can take place. Induced by the photon decay, the two‐mode correlated multiphoton bundle emission occurs in this system. More importantly, the results show that there is an antibunching effect between the strongly‐correlated photon bundles, so that the system behaves as an antibunched ()‐photon source. The work opens up a route toward achieving two‐mode correlated multiphoton source device, which has potential applications in modern quantum technology.