bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUASI PROGRAM E-KELURAHAN DI KOTA PADANG MENGGUNAKAN E-GOVERNMENT MATURITY MODEL
Authors: Rusnita Widya Cancer , Aromatica Desna , Putera Roni Ekha 
Published: December 2023

E-Kelurahan is a web-based application e-Governemnt at Kelurahan used for document publishing. The results of the 2022 research regarding the effectiveness of the e-Kelurahan program at Padang City have not been effective. So this research aims to evaluate e-Kelurahan services using Maturity e-Government Models, used is the Five pillars of e-Government put forward by Fietkiewicz, Mainka Stock in 2017 which consist of Information Dissemination, Communication, Transactions, Interoperability, and Participation which is the latest evolution of the theory of E-Government Maturity Models. The research method uses descriptive qualitative. According to the findings of this study, not all pillars have been fulfilled by e-Kelurahan, especially the pillars of communication, transaction, interoperability, and participation. There was a decline in the e-Kelurahan function due to a lack of preparedness of human resources and a lack of support in terms of budget. So that the implementation of e-Kelurahan objectives to make it easier for the public to access services online and improve the quality of services in Kelurahan was not well achieved. The drawback of this theory, the analysis only focuses on website development, ignoring other factors such as organization, resources, and supervision which are also implementation problems.E-Kelurahan adalah aplikasi berbasis web di kelurahan yang digunakan untuk penerbitan dokumen. Hasil penelitian tahun 2022 tentang efektivitas program e-Kelurahan di Kota Padang menunjukkan bahwa penerapan e-kelurahan belum efektif. Maka penelitian ini bertujuan untuk mengevaluasi layanan e-Kelurahan menggunakan Maturity e-Government Models, yakni lima pilar e-Government yang dikemukakan oleh Fietkiewicz, Mainka Stock pada tahun 2017 yang terdiri dari Penyebarluasan Informasi, Komunikasi, Transaksi, Interoperabilitas dan Partisipasi yang merupakan evolusi terbaru dari teori E-Government Maturity Models. Metode penelitian menggunakan deskriptif kualitatif. Berdasarkan temuan penelitian ini, belum semua pilar dipenuhi oleh e-Kelurahan, terutama pilar komunikasi, transaksi, interoperabilitas dan partisipasi. Terjadi penurunan fungsi e-Kelurahan karena kurangnya kesiapan sumber daya manusia dan kurangnya dukungan dari segi anggaran. Sehingga implementasi tujuan e-Kelurahan untuk memudahkan masyarakat mengakses layanan secara online dan meningkatkan kualitas layanan di Kelurahan tidak tercapai dengan baik. Kelemahan dari teori ini, analisis hanya fokus pada pengembangan website, mengabaikan faktor lain seperti organisasi, sumber daya dan pengawasan yang juga merupakan masalah implementasi.
SEPAK BOLA DAN KESETARAAN GENDER DALAM KAMPANYE IKLAN NIKE BERTAJUK “NEVER SETTLE, NEVER DONE”
Authors: Alvicky Angga , Sinduwiatmo Kukuh 
Published: December 2023

With the protests and discussions about gender equality in football and the momentum of Women's EURO 2022, Nike, a clothing brand in the world's biggest sport, released a commercial titled "Never Settle, Never Done" via video 1 minute 12 seconds long, uploaded via his official YouTube channel, featuring freestyler Rocky Hehakaija, England captain Leah Williamson, Alexia Putellas, Magda Erikssonand Marie-Antoinette Katoto. This research musedescriptive qualitative method with the theory of semiotics from Roland Barthes, the researcher aims to understand the meaning and message contained in the advertising video by uncovering the myths constructed by the video maker (Nike) based on the signification system and the symbols shown. Researchers managed to understand that through advertising "Never Settle, Never Done”, Nike is trying to create gender equality by promoting football as an activity that is not only done by men but women can also take part and do it. Nike wants to change the stereotype of football, which is synonymous with masculine words, and creates the fact that football does not look at gender, race and so on.highlighting the speed, technical ability and quality of women's football has never been higher. Nike is showing the world that women's soccer is a force to be reckoned with and it will remain.Dengan maraknya protes dan diskusi tentang kesetaraan gender dalam sepak bola dan beriringan dengan momentum Women's EURO 2022. Nike, merupakan merek pakaian olahraga terbesar di dunia, merilis kampanye iklan berjudul "Never Settle, Never Done" melalui video berdurasi 1 menit 12 detik, diunggah melalui saluran YouTube resminya, menampilkan freestyler Rocky Hehakaija, kapten Inggris Leah Williamson, Alexia Putellas, Magda Eriksson dan Marie-Antoinette Katoto. Penelitian ini menggunakan metode kualitatif deskriptif dengan teori semiotika dari Roland Barthes, peneliti bertujuan memahami makna dan pesan yang terkandung dalam video iklan tersebut dengan cara mengungkap mitos yang dikonstruksikan oleh pembuat video (Nike) berdasarkan sistem signifikasi dan simbol-simbol yang tertera. Peneliti berhasil memahami bahwa melalui iklan “Never Settle, Never Done”, Nike berusaha menciptakan kesetaraan gender dengan melambungkan sepak bola sebagai aktivitas yang tidak hanya dilakukan kaum laki-laki namun perempuan juga bisa ikut andil dan melakukannya. Nike hendak mengubah stereotip sepak bola yang identik dengan kata maskulin dan menciptakan fakta bahwa olahraga sepak bola tidak memandang gender, ras dan sebagainya dengan menyoroti kecepatan, kemampuan teknis, dan kualitas sepak bola perempuan yang tidak pernah setinggi ini. Nike menunjukkan kepada dunia bahwa sepak bola perempuan adalah kekuatan yang harus diperhitungkan dan akan tetap ada.
DETERMINAN KEBERHASILAN USAHA PADA SENTRA KERAJINAN GERABAH
Authors: Anandita Zulia Putri  , Idha Ayu Isnaini  , Ningrum Pramudiati  
Published: December 2023

The purpose of this study was to determine whether entrepreneurial characteristics, use of accounting information and accounting attitudes had an effect on business success. This type of research method is quantitative research. This study uses primary data in the form of a questionnaire that is distributed directly to the owners of MSMEs. The population of this research is all pottery and leather handicraft centers in Bantul Regency, the sampling technique uses purposive sampling technique with the criteria of length of business, initial capital, MSMEs that have been registered in the Bantul Regency Cooperatives and SME Service and MSMEs that have recorded their business, the sample obtained as many as 99 respondents. The data analysis technique used multiple linear regression analysis with the help of the SPSS v.25 tool. The results of this study state that partially and simultaneously entrepreneurial characteristics, use of accounting information and accounting attitudes have an effect on business success.
STUDI EKSPERIMEN TEMPERATUR, DAYA DAN WAKTU PADA PEMANAS MESIN ROASTING KOPI OTOMATIS BERKAPASITAS 5 KG
Authors: Maulana Junianto  
Published: December 2023

Mesin roasting kopi merupakan sebuah mesin yang digunakan untuk menyangrai biji kopi agar matang. Prinsip kerja mesin ini adalah biji kopi dipanaskan dalam ruang sangrai yang berputar dengan suhu yang telah ditentukan, sehingga pemanasan bisa merata. Proses mesin roasting biji kopi dapat dilakukan pengaturan temperature, yang mana elemen pemanas alat menggunakan komponen Band Heater. Band Heater berbentuk seperti tabung dengan fungsi sebagai pemanas untuk memanaskan silinder dengan ukuran tertentu yang mempunyai kelebihan antara lain adalah suhu operasi tinggi, pemanasan cepat, efisiensi panas tinggi, ramah lingkungan, bahkan dan pemanasan akurat, dapat mengatur sistem kontrol otomatis.
Tujuan dari penelitian ini adalah membuat rancang bangun mesin roasting kopi yang terkendali menggunakan sistem pemanas elektrik tipe band heater dengan kapasitas 5 kg serta mengetahui pengontrolan temperature PID Rex-C100 pada mesin roasting kopi berkapasitas 5 kg. Penelitian ini menunjukkan kenaikan temperature tiap 10 menit selama proses roasting, grafik selisih temperature tiap 10 menit selama proses roasting, data hasil pengukuran suhu sistem pemanas, grafik hubungan antara temperature band heater terhadap aliran panas, perbandingan temperature band heater dengan ruang roasting, dan grafik daya yang dibutuhkan band heater.
Mediation Effect of Work Stress on the Relationship between Role Conflict, Role Ambiguity, and Employees Performance
Authors: Wahjoedi Tri 
Published: December 2023

Purpose – The aim of this study was to examine how role conflict and role ambiguity, mediated by work stress, influenced employees performance.
Methodology – A quantitative analysis was performed by using the Slovin formula for a total sample of 114 employees from PT MSP, a prominent household appliances company in East Java, Indonesia. The collected data were analyzed using SEM SmartPls-3.
Results – The results showed that both role conflict and role ambiguity exerted a significant negative impact on employees performance, and also contributed to increased work stress. Moreover, work stress showed a significant negative impact on employees performance. The inclusion of work stress as an intermediary highlighted its role in mediating the negative relationship between role conflict, role ambiguity, and employees performance.
Originality – Incorporating work stress as a mediator in the connection between these variables enriched the exploration of the interrelation. This intricate relationship required a deeper understanding for the optimization of employees performance.
Magnetically‐actuated microcages for cells entrapment, fabricated by laser direct writing via two photon polymerization
Authors: Popescu Roxana Cristina , Calin Bogdan Stefanita , Tanasa Eugenia , Vasile Eugeniu , Mihailescu Mona , Paun Irina Alexandra 
Published: December 2023

The manipulation of biological materials at cellular level constitutes a sine qua non and provocative research area regarding the development of micro/nano‐medicine. In this study, we report on 3D superparamagnetic microcage‐like structures that, in conjunction with an externally applied static magnetic field, were highly efficient in entrapping cells. The microcage‐like structures were fabricated using Laser Direct Writing via Two‐Photon Polymerization (LDW via TPP) of IP‐L780 biocompatible photopolymer/iron oxide superparamagnetic nanoparticles (MNPs) composite. The unique properties of LDW via TPP technique enabled the reproduction of the complex architecture of the 3D structures, with a very high accuracy i.e., about 90 nm lateral resolution. 3D hyperspectral microscopy was employed to investigate the structural and compositional characteristics of the microcage‐like structures. Scanning Electron Microscopy coupled with Energy Dispersive X‐Ray Spectroscopy was used to prove the unique features regarding the morphology and the functionality of the 3D structures seeded with MG‐63 osteoblast‐like cells. Comparative studies were made on microcage‐like structures made of IP‐L780 photopolymer alone (i.e., without superparamagnetic properties). We found that the cell‐seeded structures made by IP‐L780/MNPs composite actuated by static magnetic fields of 1.3 T were 13.66 ± 5.11 folds (p &lt; 0.01) more efficient in terms of cells entrapment than the structures made by IP‐L780 photopolymer alone (i.e., that could not be actuated magnetically). The unique 3D architecture of the microcage‐like superparamagnetic structures and their actuation by external static magnetic fields acted in synergy for entrapping osteoblast‐like cells, showing a significant potential for bone tissue engineering applications.
A time-resolved fluorescence microsphere-lateral flow immunochromatographic strip for quantitative detection of Pregnanediol-3-glucuronide in urine samples
Authors: Lin Jiasheng , Li Sanhua , Ye Benchen , Zheng Weigang , Wang Huihui , Liu Ying , Wang Dong , Wu Zaihui , Dong Wen-Fei , Zan Minghui 
Published: December 2023

Introduction: Pregnanediol-3-glucuronide (PdG), as the main metabolite of progesterone in urine, plays a significant role in the prediction of ovulation, threatened abortion, and menstrual cycle maintenance.Methods: To achieve a rapid and sensitive assay, we have designed a competitive model-based time-resolved fluorescence microsphere-lateral flow immunochromatography (TRFM-LFIA) strip.Results: The optimized TRFM-LFIA strip exhibited a wonderful response to PdG over the range of 30–2,000 ng/mL, the corresponding limit of detection (LOD) was calculated as low as 8.39 ng/mL. More importantly, the TRFM-LFIA strip was innovatively used for the quantitative detection of PdG in urine sample, and excellent recovery results were also obtained, ranging from 97.39% to 112.64%.Discussion: The TRFMLFIA strip possessed robust sensitivity and selectivity in the determination of PdG, indicating the great potential of being powerful tools in the biomedical and diagnosis region.
Synergistic potential of teriflunomide with fluconazole against resistant Candida albicans in vitro and in vivo
Authors: Li Xiuyun , Kong Bing , Sun Yaqiong , Sun Fenghua , Yang Huijun , Zheng Shicun 
Published: December 2023

IntroductionCandida albicans is the primary cause of systemic candidiasis, which is involved in high morbidity and mortality. Drug resistance exacerbates these problems. In addition, there are limited antifungal drugs available. In order to solve these problems, combination therapy has aroused great interest. Teriflunomide is an immunosuppressant. In the present work, we aimed to identify whether teriflunomide can reverse the resistance of Candida albicans in the presence of sub-inhibitory concentrations of fluconazole in vitro and in vivo.MethodsSeven Candida albicans isolates were used in this study. Susceptibility of Candida albicans in vitro to the drugs was determined using a checkerboard microdilution assay in accordance with the recommendations of the Clinical and Laboratory Standards Institute. The effects of drugs on biofilm biomass of Candida albicans were determined by crystal violet staining. The development ability of Candida albicans hyphae was performed using a modified broth microdilution method. Galleria mellonella was used for testing the in vivo efficacy of the combination therapies. ResultsWe found that the combination of teriflunomide (64 µg/mL) and fluconazole (0.5-1 µg/mL) has a significant synergistic effect in all resistant Candida albicans isolates (n=4). Also, this drug combination could inhibit the immature biofilm biomass and hyphae formation of resistant Candida albicans. Galleria mellonella was used for testing the in vivo efficacy of this combination therapies. As for the Galleria mellonella larvae infected by resistant Candida albicans, teriflunomide (1.6 µg/larvae) combined with fluconazole (1.6 µg/larvae) significantly increased their survival rates, and reduced the fungal burden, as well as damage of tissue in comparison to that in the control group or drug monotherapy group. ConclusionThese results expand our knowledge about the antifungal potential of teriflunomide as an adjuvant of existing antifungal drugs, and also open new perspectives in the treatment of resistant Candida albicans based on repurposing clinically available nonantifungal drugs.
Mechanism of carbonate assimilation by intraplate basaltic magma and liquid immiscibility: example of Wangtian’e volcano (Changbaishan volcanic area, NE China)
Authors: Andreeva Olga A. , Dubinina Elena , Andreeva Irina A. , Yarmolyuk Vladimir V. , Bychkov Andrey , Borisova Anastassia , Ji Jianqing , Zhou Xin , Kovalchuk Elena V. , Borisovsky Sergey Y. , Averin Alexey A. 
Published: December 2023

The balance of CO2 during abundant basaltic magma production is an important factor of volcanic hazards and climate. In particular, this can be explored based on CO2-rich mantle-derived magmas or carbonate assimilation by basaltic melts. To reconstruct the origin of Fe-rich carbonates hosted by Cenozoic basalts from Wangtian’e volcano (northeast China), we studied elemental compositions of melt, crystalline and fluid inclusions in magmatic minerals as well as the oxygen and carbon isotope compositions of the plagioclase and carbonates from basalts. The crystallization of basaltic magmas occurred in shallow chamber (∼4 km) at temperatures of 1,180°C–1,200°C and a pressure of 0.1 ± 0.01 GPa. Stable Fe-rich carbonates occur in the Wangtian’e tholeiite basalts as groundmass minerals, crystalline inclusions in plagioclase and globules in melt inclusions, which suggests that they crystallized from a ferrocarbonate melt. The values of δ18О and δ13С in the minerals analyzed by laser fluorination method are in line with the sedimentary source of Fe-rich carbonates, indicating assimilation and partial decomposition of carbonate phases. The parent ferrocarbonate melt could be produced during interactions between the basaltic magma and the crustal marbles. The phase diagram and thermodynamic calculations show that the ferrocarbonate melt is stable at a temperature of 1,200°C and a pressure of 0.1 GPa. Our thermodynamic calculations show that carbonate melt containing 73 wt% FeCO3, 24 wt% MgCO3 and 3 wt% CaCO3 is in thermodynamic equilibrium with silicate melt in agreement with our natural observations. The proposed mechanism is crustal carbonate sediment assimilation by the intraplate basaltic magma resulting in the melt immiscibility, production of the ferrocarbonate melt and the following Fe-rich carbonate mineral crystallization during magma residence and cooling.
Mendelian randomization indicates causal effects of estradiol levels on kidney function in males
Authors: Nasr M. Kamal , Schurmann Claudia , Böttinger Erwin P. , Teumer Alexander 
Published: December 2023

ContextChronic kidney disease (CKD) is a public health burden worldwide. Epidemiological studies observed an association between sex hormones, including estradiol, and kidney function.ObjectiveWe conducted a Mendelian randomization (MR) study to assess a possible causal effect of estradiol levels on kidney function in males and females.DesignWe performed a bidirectional two-sample MR using published genetic associations of serum levels of estradiol in men (n = 206,927) and women (n = 229,966), and of kidney traits represented by estimated glomerular filtration rate (eGFR, n = 567,460), urine albumin-to-creatinine ratio (UACR, n = 547,361), and CKD (n = 41,395 cases and n = 439,303 controls) using data obtained from the CKDGen Consortium. Additionally, we conducted a genome-wide association study using UK Biobank cohort study data (n = 11,798 men and n = 6,835 women) to identify novel genetic associations with levels of estradiol, and then used these variants as instruments in a one-sample MR.ResultsThe two-sample MR indicated that genetically predicted estradiol levels are significantly associated with eGFR in men (beta = 0.077; p = 5.2E-05). We identified a single locus at chromosome 14 associated with estradiol levels in men being significant in the one-sample MR on eGFR (beta = 0.199; p = 0.017). We revealed significant results with eGFR in postmenopausal women and with UACR in premenopausal women, which did not reach statistical significance in the sensitivity MR analyses. No causal effect of eGFR or UACR on estradiol levels was found.ConclusionsWe conclude that serum estradiol levels may have a causal effect on kidney function. Our MR results provide starting points for studies to develop therapeutic strategies to reduce kidney disease.
Exploring the implications of blocking renin-angiotensin-aldosterone system and fibroblast growth factor 23 in early left ventricular hypertrophy without chronic kidney disease
Authors: Watanabe Kentaro , Fujii Hideki , Okamoto Kohei , Kono Keiji , Goto Shunsuke , Nishi Shinichi 
Published: December 2023

BackgroundWhether fibroblast growth factor 23 (FGF23) directly induces left ventricular hypertrophy (LVH) remains controversial. Recent studies showed an association between FGF23 and the renin-angiotensin-aldosterone system (RAAS). The aim of this study was to investigate changes in FGF23 levels and RAAS parameters and their influences on LVH.MethodsIn the first experiment, male C57BL/6J mice were divided into sham and transverse aortic constriction (TAC) groups. The TAC group underwent TAC at 8 weeks of age. At 1, 2, 3, and 4 weeks after TAC, the mice were sacrificed, and blood and urine samples were obtained. Cardiac expressions of FGF23 and RAAS-related factors were evaluated, and cardiac histological analyses were performed. In the second experiment, the sham and TAC groups were treated with vehicle, angiotensin-converting enzyme (ACE) inhibitor, or FGF receptor 4 (FGFR4) inhibitor and then evaluated in the same way as in the first experiment.ResultsIn the early stage of LVH without chronic kidney disease, serum FGF23 levels did not change but cardiac FGF23 expression significantly increased along with LVH progression. Moreover, serum aldosterone and cardiac ACE levels were significantly elevated, and cardiac ACE2 levels were significantly decreased. ACE inhibitor did not change serum FGF23 levels but significantly decreased cardiac FGF23 levels with improvements in LVH and RAAS-related factors, while FGFR4 inhibitor did not change the values.ConclusionsNot serum FGF23 but cardiac FGF23 levels and RAAS parameters significantly changed in the early stage of LVH without chronic kidney disease. RAAS blockade might be more crucial than FGF23 blockade for preventing LVH progression in this condition.
Characterization of circulating extracellular traps and immune responses to citrullinated LL37 in psoriasis
Authors: Martín Monreal María Teresa , Kvist-Hansen Amanda , Massarenti Laura , Steffensen Rudi , Loft Nikolai , Hansen Peter Riis , Ødum Niels , Skov Lone , Nielsen Claus H. 
Published: December 2023

BackgroundThe DNA-binding peptide LL37 is a suspected autoantigen in psoriasis. It can be found in neutrophil extracellular traps (NETs) which have been suggested to play a role in the pathogenesis of the disease. Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, can be implicated in the formation of NETs. We hypothesized that citrullination increases LL37 immunogenicity and that NETs are a source of LL37.ObjectivesWe aimed to characterize cytokine responses of B cells and T cells to native and citrullinated LL37 (citLL37) and determine the prevalence and composition of circulating NETs in patients with psoriasis and healthy blood donors (HDs).MethodsMononuclear cells (MNCs) and serum were isolated from 20 HDs and 20 patients with psoriasis. The MNCs were stimulated with native LL37 and citLL37 and the proportion of cytokine-positive B cells and T cells was determined by flow cytometry. Circulating antibodies against native LL37 and citLL37 as well as circulating NETs were measured by ELISA, as was the content of LL37, citLL37, and IgG in the NETs.ResultsCitLL37, but not native LL37, induced IFN-γ-production by T cells and B cells from psoriasis patients, as well as IL-10-production by the patients’ CD4+ T cells. Serum from 40% of patients and 55% of HDs contained circulating NETs, of which 63% and 27%, respectively, contained LL37. Only two patients had NETs containing citLL37 and IgG antibodies were found in NETs from three patients and one HD. Post-hoc analysis of the cytokines produced by B cells and T cells after stimulation with citLL37 revealed two clusters of patients consisting of 10 high-responders and 9 low-responders. The high-responders were those that had circulating NETs in combination with an earlier age of onset of the disease.ConclusionCitrullinated but not native LL37 elicits IFN-γ-responses by T cells and B cells from psoriasis patients, particularly those with circulating NETs and early disease onset, suggesting a role of citLL37 as an autoantigen in this subgroup of patients.