bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age and Gender‐Dependence of Single‐and Bi‐Exponential T1ρ MR Parameters in Knee Ligaments
Authors: Lise de Moura Hector , Kijowski Richard , Zhang Xiaoxia , Sharafi Azadeh , Zibetti Marcelo V. W. , Regatte Ravinder 
Published: October 2023

BackgroundThere is limited understanding of differences in the composition and structure of ligaments between healthy males and females, and individuals of different ages. Females present higher risk for ligament injuries than males and there are conflicting reports on its cause. This study looks into T1ρ parameters for an explanation as it relates to proteoglycan, collagen, and water content in these tissues.PurposeTo investigate gender‐related and age‐related differences in T1ρ parameters in knee joint ligaments in healthy volunteers using a T1ρ‐prepared zero echo‐time (ZTE)‐based pointwise‐encoding time‐reduction with radial acquisition (T1ρ‐PETRA) sequence.Study TypeProspective.PopulationThe study group consisted of 22 healthy subjects (11 females, ages: 41 ± 18 years, and 11 males, ages: 41 ± 14 years) with no known inflammation, trauma, or pain in the knee joint.Field Strength/SequenceA T1ρ‐prepared 3D‐PETRA sequence was used to acquire fat‐suppressed images with varying spin‐lock lengths (TSLs) of the knee joint at 3T.AssessmentMonoexponential, biexponential, and stretched‐exponential 3D‐PETRA‐T1ρ parameters were measured in the anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), and patellar tendon (PT) by manually drawing ROIs over the entirety of the tissues.Statistical TestsMann–Whitney U‐tests were used to compare 3D‐PETRA‐T1ρ parameters in the ACL, PCL, and PT between males and females. Spearman correlation coefficients were used to determine the association between age and T1ρ parameters. Statistical significance was defined as P < 0.05.ResultsSignificant correlations with age were found the three ligaments with most of the measured T1ρ parameters (rs = 0.28–0.74) with the exception of the short fraction in the PCL (P = 0.18), and the short relaxation time in the ACL (P = 0.58) and in the PCL (P = 0.14).Data Conclusion3D‐PETRA‐T1ρ can detect age‐related differences in monoexponential, biexponential, and stretched‐exponential T1ρ parameters in three ligaments of healthy volunteers, which are thought to be related to changes in tissue composition and structure during the aging process.Level of Evidence2Technical EfficacyStage 1
Re‐Creating Higher Education Pedagogy by Making Materiality and Spatiality Matter
Authors: Chappell Kerry , Witt Sharon , Wren Heather , Hampton Leonie , Woods Pam , Swinford Lizzie , Hampton Martin 
Published: October 2023

ABSTRACTThis study marks a resting point within ongoing explorations of creativity, transdisciplinarity, materiality, and spatiality in Higher Education (HE) pedagogy. It interrogates how different materialities and spatialities shape learning to re‐create practices to better respond to societal challenges. This is situated within an imperative to move away from Western‐dominated approaches to pedagogy and research, where “Western” is characterized as onto‐epistemological rather than place‐based. The study draws on postqualitative enquiry into two creative, transdisciplinary HE courses, which entwined the arts, sciences, and entrepreneurship to facilitate responses to societal problems. Framed using posthumanizing creativity, the research aims to decenter the human and posit creativity as a dialogic, intra‐active process with the capacity to change education from within. A postqualitative approach works through three data diffractions. The first two involve glow moments used for collaging, cut through with theory. The third diffraction involves glow moments from which a short dance film was created. The study aims to stir readers/engagers to action their creativity as feeding forward into their own work in HE pedagogies, to consider how to move beyond the word, and the influences all of this can have on reimagining practices and changing structures.
Effect of Matrix Stiffness and Hepatocyte Growth Factor on Small Cell Lung Cancer Cells in Decellularized Extracellular Matrix‐Based Hydrogels
Authors: Han Yoobin , Ki Chang Seok 
Published: October 2023

AbstractSmall cell lung cancer (SCLC) is one of lethal cancers resulting in very low 5‐year‐survival rate. Although its clinical treatment largely relies on chemotherapy, SCLC cell physiology in three‐dimenstional (3D) matrix has been less explored. In this work, the tumor microenvironment is reconstructed with decellularized porcine pulmonary extracellular matrix (dECM) with hyaluronic acid. To modulate matrix stiffness, the methacrylate groups are introduced into both dECM and hyaluronic acid, followed by photocrosslinking with photoinitiator. The stiffness of the resulting dECM‐based hydrogel covers the stiffness of normal or cancerous tissue with varying dECM content. The proliferation and cancer stem cell marker expression of encapsulated SCLC cells are promoted in a compliant hydrogel matrix, which has a low shear modulus similar to that of the normal tissue. The hepatocyte growth factor (HGF) that induces SCLC cell invasion and chemoresistance markedly increases invasiveness and gene expression levels of CD44 and Sox2 in the hydrogel matrix. In addition, HGF treatment causes higher resistance against anticancer drugs (cisplatin and paclitaxel) in the 3D microenvironment. These findings indicate that malignant SCLC can be recapitulated in a pulmonary dECM‐based matrix.
Transparent and Soft Crack‐Resistant Bouligand Elastomers Inspired by Fish Scales
Authors: Shu Jingheng , Teng Qiancheng , Zhang Hao , Wu Jinrong , Liu Zhan 
Published: October 2023

AbstractNature with its abundant source offers numerous inspirations for structural and engineering designs. The oriented membranes stacked with bouligand structures in the fish scales show an outstanding combination of high strength and crack resistance. Although the applications of hard biomimetic composites are reported, the structures are rarely utilized in soft materials. Inspired by the scales of various fishes, electrospun membranes are used and stacked to fabricate bouligand elastomers, including orthogonal‐plywood, single‐bouligand, and double‐bouligand structures. The effects of different structures on the properties of elastomers are systematically investigated and possible mechanism is explained using finite element analysis (FEA). The stiffness and fatigue characteristics of these biomimetic elastomers with the above structures are improved compared with the original membranes, especially the elastomers with a single‐bouligand structure, which can undergo 5 000 cycles at a maximum strain of 35% without complete failure. The crack only propagates to half of the width of the elastomer with remaining strength of 50% of its original strength. Moreover, the mechanical performance can be adjusted by regulating the proportion of the components. The excellent crack‐resistant properties and transparency promote its various potential applications.
Valproic acid increased the efficacy of EGFR TKIs on EGFR/TP53 co‐mutated lung cancers and downregulated mutant‐p53 levels
Authors: Hu Mengdi , Cheng Hanyue , Yang Yijing , Xu Lu 
Published: October 2023

AbstractThe TP53 tumor suppressor is the most frequently mutated gene in human cancers. For p53‐targeted therapy, one of the strategies was targeting mutant p53 for degradation. In EGFR‐mutated lung cancer patients, concurrent TP53 mutation was associated with faster resistance to EGFR‐TKIs. In this study, we discovered that valproic acid (VPA), a widely prescribed antiseizure medication, had a synergic effect on sensitive as well as acquired resistant lung cancers with EGFR/TP53 co‐mutation in combination with EGFR‐TKIs. In both in vitro and in vivo models, VPA greatly improved the efficacy of EGFR‐TKIs, including forestalling the occurrence of acquired resistance and increasing the sensitivity to EGFR‐TKIs. Mechanistically, VPA dramatically promoted degradation of mutant p53 in both sensitive and acquired resistant cells while inhibited mutant TP53 mRNA transcription only in sensitive cells. Together, this study suggested that VPA combination treatment could have beneficial effects on EGFR‐mutant lung cancers with concurrent p53 mutation in both early and late stages, expanding the potential clinical applications for VPA.
COPA syndrome caused by a novel p.Arg227Cys COPA gene variant
Authors: Zheng Yue , Du Yue , Wu Yubin , Li Fuwei , Gu Weiyue , Zhao Chengguang 
Published: October 2023

AbstractBackgroundCOPA syndrome is a recently described and rare monogenic autosomal dominant disease caused by heterozygous missense mutations in the Coatomer Protein Subunit alpha (COPA) gene that encodes the alpha subunit of coat protein complex I (COPI). Its main clinical manifestations are inflammatory lung disease, arthritis, and renal disease. The development of inflammation in COPA syndrome maybe due to abnormal autophagic response and abnormal activation of type I interferon pathway. To date, 59 cases of COPA have been reported worldwide.MethodsIn this case, Trio‐whole exome sequencing was employed in the proband and her parents to identify the underlying genetic cause. COPA variant were detected and the clinical presentation of the patient was described.ResultsHerein, we report a case of a 5‐year‐old girl with COPA syndrome who presented with symptoms of arthritis combined with Anti‐neutrophil Cytoplasmic Antibody (ANCA) associated vasculitis (AAV), and progressive renal decline with minimal pulmonary involvement. Trio‐whole exome sequencing was performed which revealed a novel heterozygous likely pathogenic variation in the COPA gene (c.679C>T,p.Arg227Cys), which was maternally inherited. Her mother was a heterozygote, but she had no phenotypic manifestations. No other mutations associated with the clinical phenotype were identified.ConclusionThe present identification and characterization of a novel mutation expands the genotypic spectra of the COPA syndrome and provide reference data to guide future clinical diagnosis and treatment of COPA syndrome.
ASL lexicon and reporting recommendations: A consensus report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)
Authors: Suzuki Yuriko , Clement Patricia , Dai Weiying , Dolui Sudipto , Fernández‐Seara Maria A. , Lindner Thomas , Mutsaerts Henk J. M. M. , Petr Jan , Shao Xingfeng , Taso Manuel , Thomas David L. ,   ISMRM Perfusion Study Group
Published: October 2023

AbstractThe 2015 consensus statement published by the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group and the European Cooperation in Science and Technology ( COST) Action ASL in Dementia aimed to encourage the implementation of robust arterial spin labeling (ASL) perfusion MRI for clinical applications and promote consistency across scanner types, sites, and studies. Subsequently, the recommended 3D pseudo‐continuous ASL sequence has been implemented by most major MRI manufacturers. However, ASL remains a rapidly and widely developing field, leading inevitably to further divergence of the technique and its associated terminology, which could cause confusion and hamper research reproducibility.On behalf of the ISMRM Perfusion Study Group, and as part of the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI), the ASL Lexicon Task Force has been working on the development of an ASL Lexicon and Reporting Recommendations for perfusion imaging and analysis, aiming to (1) develop standardized, consensus nomenclature and terminology for the broad range of ASL imaging techniques and parameters, as well as for the physiological constants required for quantitative analysis; and (2) provide a community‐endorsed recommendation of the imaging parameters that we encourage authors to include when describing ASL methods in scientific reports/papers.In this paper, the sequences and parameters in (pseudo‐)continuous ASL, pulsed ASL, velocity‐selective ASL, and multi‐timepoint ASL for brain perfusion imaging are included. However, the content of the lexicon is not intended to be limited to these techniques, and this paper provides the foundation for a growing online inventory that will be extended by the community as further methods and improvements are developed and established.
A database for MR‐based electrical properties tomography with in silico brain data—ADEPT
Authors: Meerbothe T. G. , Meliado E. F. , Stijnman P. R. S. , van den Berg C. A. T. , Mandija S. 
Published: October 2023

AbstractPurposeSeveral reconstruction methods for MR‐based electrical properties tomography (EPT) have been developed. However, the lack of common data makes it difficult to objectively compare their performances. This is, however, a necessary precursor for standardizing and introducing this technique in the clinical setting. To enable objective comparison of the performances of reconstruction methods and provide common data for their training and testing, we created ADEPT, a database of simulated data for brain MR‐EPT reconstructions.MethodsADEPT is a database containing in silico data for brain EPT reconstructions. This database was created from 25 different brain models, with and without tumors. Rigid geometric augmentations were applied, and different electrical properties were assigned to white matter, gray matter, CSF, and tumors to generate 120 different brain models. These models were used as input for finite‐difference time‐domain simulations in Sim4Life, used to compute the electromagnetic fields needed for MR‐EPT reconstructions.ResultsElectromagnetic fields from 84 healthy and 36 tumor brain models were simulated. The simulated fields relevant for MR‐EPT reconstructions (transmit and receive RF fields and transceive phase) and their ground‐truth electrical properties are made publicly available through ADEPT. Additionally, nonattainable fields such as the total magnetic field and the electric field are available upon request.ConclusionADEPT will serve as reference database for objective comparisons of reconstruction methods and will be a first step toward standardization of MR‐EPT reconstructions. Furthermore, it provides a large amount of data that can be exploited to train data‐driven methods. It can be accessed from
https://doi.org/10.34894/V0HBJ8.
A test of the New Coimbra method of recording entheseal changes as applied to the foot skeleton
Authors: Albee Malorie E. 
Published: October 2023

AbstractPrior studies have indicated that entheseal changes throughout the skeleton are largely reflective of age and body mass with mixed results concerning activity patterns. To add to this debate, this study tests the effectiveness of employing the New Coimbra method to record entheseal changes of the calcaneus (Calcaneal tendon enthesis), hallucal metatarsal (Peroneus longus m. tendon, and Tibialis anterior m. tendon entheses), and fifth metatarsal (Peroneus brevis m. tendon enthesis) to understand past activity patterns. Presence and severity of entheseal changes were scored for 71 white adults from the William M. Bass Donated Skeletal Collection, and these scores were contrasted according to age, sex, stature, body mass (BMI), and occupation. Spearman's rank correlations show that age has the greatest impact on changes for the Calcaneal tendon enthesis, the Peroneus brevis m. tendon enthesis, and the Tibialis anterior m. tendon enthesis. For all of these entheses, entheseal scores increase as age increases. Stature is the largest contributing factor to changes in the Peroneus longus m. tendon enthesis, and this relationship is negative: entheseal scores decrease as stature increases. BMI has a limited effect on entheseal changes in the foot skeleton, and this relationship may instead be mediated by gait differences related to stature. No statistically significant relationships between entheseal changes and occupational standing ranks were found, although this may be related to the ways in which occupations were recorded and ranked. It is possible that statistically significant effects of physical activity patterns on the expression of entheseal changes could be documented using other measurements of activity patterns beyond occupational standing. These findings support prior studies that established age as a major contributor to entheseal changes but show that stature also contributes to enthesis formation in the foot.
A natural death assemblage of fishes from an early modern archeological context in Antwerp (Belgium)
Authors: Wouters Wim , Van Neer Wim , Celis Daan 
Published: October 2023

AbstractAn unusual concentration of tens of thousands small fish remains discovered during rescue excavations in the town of Antwerp, Belgium, is described. The material was found in a small depression with no associated archeological material but could be dated to the first half of the 16th century based on its stratigraphic position. About 3500 freshwater fish were found in articulating position and it is shown that they died naturally during a single depositional event after an exceptional flood. The species spectrum and the reconstructed fish lengths make it possible to document the season when the catastrophic mortality occurred. This assemblage differs from the few assemblages of natural mortality reported in the literature, which are all of the attritional type.
Photosynthetic and transcriptome responses to fluctuating light in Arabidopsis thylakoid ion transport triple mutant
Authors: Gollan Peter J. , Grebe Steffen , Roling Lena , Grimm Bernhard , Spetea Cornelia , Aro Eva‐Mari 
Published: October 2023

AbstractFluctuating light intensity challenges fluent photosynthetic electron transport in plants, inducing photoprotection while diminishing carbon assimilation and growth, and also influencing photosynthetic signaling for regulation of gene expression. Here, we employed in vivo chlorophyll‐a fluorescence and P700 difference absorption measurements to demonstrate the enhancement of photoprotective energy dissipation of both photosystems in wild‐type Arabidopsis thaliana after 6 h exposure to fluctuating light as compared with constant light conditions. This acclimation response to fluctuating light was hampered in a triple mutant lacking the thylakoid ion transport proteins KEA3, VCCN1, and CLCe, leading to photoinhibition of photosystem I. Transcriptome analysis revealed upregulation of genes involved in biotic stress and defense responses in both genotypes after exposure to fluctuating as compared with constant light, yet these responses were demonstrated to be largely upregulated in triple mutant already under constant light conditions compared with wild type. The current study illustrates the rapid acclimation of plants to fluctuating light, including photosynthetic, transcriptomic, and metabolic adjustments, and highlights the connection among thylakoid ion transport, photosynthetic energy balance, and cell signaling.
Topographical effect of high embankments on resistivity investigation of the underlying permafrost table
Authors: You Yanhui , Pan Xicai , Fu Wei , Wang Yun , Yu Qihao , Guo Lei , Wang Xinbin 
Published: October 2023

AbstractInvestigation of resistivity has been effectively used in assessing the risks of embankmentation and failure. A two‐dimensional (2D) approximation of the surveyed object is commonly assumed for a survey line on the road surface. However, this approximation may not be met when resistivity investigations are conducted over a raised high embankment; under these conditions, regular inversions might yield erroneous results. This study explored the topographical effect of a high embankment on resistivity measurements by forward and inverse modeling of a 3D high embankment model. The results show that a 2D approximation of the survey lines on the road surface significantly increases the apparent resistivity within the depth of the raised embankment. Maximum relative errors reached 21% and 11% for the road shoulder and midline survey lines, respectively. The biased apparent resistivity resulted in an inverted resistivity that was higher than the true values, although resistivity contrasts can still identify interfaces between layers. A geometric factor was used to correct the biased apparent resistivity to eliminate the high embankment topographical effect. Inversion results of the corrected apparent resistivity agreed well with the forward model. The method was then verified by field application. The apparent resistivity of the field data collected on a high embankment in permafrost regions on the Qinghai–Tibet Plateau was corrected before inversion. The permafrost table derived from the inverted resistivity was verified based on borehole temperatures. These findings indicate that the topographical influence of high embankments on resistivity measurements needs to be considered. Correction of the apparent resistivity is indispensable for quantitative interpretation of the inverted resistivity.
Carbon Dot‐Based Fluorescence Resonance Energy Transfer (FRET) Systems for Biomedical, Sensing, and Imaging Applications
Authors: Gopal Abhilash Raj , Joy Francis , Dutta Vishal , Devasia Jyothis , Dateer Ramesh , Nizam Aatika 
Published: October 2023

AbstractCarbon dots (CDs) emerge as a potential group of photo‐luminescent nano‐materials due to their excellent optical, electrical, and chemical properties, as well as their competence in a wide range of environmental applications. CDs have unique and appealing properties such as excellent stability, low toxicity, water solubility, and derivability. When coupled with CDs, fluorescence resonance energy transfer (FRET) results in the development of highly sensitive ratiometric fluorescence sensor probes with potential applications in bio‐imaging, metal sensing, membrane dynamics, and environmental sensing. In this review, the progress and recent developments in CDs based FRET systems utilized for various environmental applications are conferred. An in‐depth description is provided regarding the numerous donor/acceptor systems which when integrated with CDs generate efficient FRET systems. The review enables researchers to identify and develop specific systems which can be utilized to generate a FRET pair with potential physico–chemical properties that aid the development of the same for various applications.
Bilateral pulmonary sequestrations: Distinct types sharing a common celiac artery origin, presented with pneumonia and associated findings in a pediatric case
Authors: Tekinhatun Muhammed , Alver Kadir Han 
Published: October 2023

AbstractA 14‐year‐old boy presented with shortness of breath, cough, and mild chest pain, with a history of intermittent milder symptoms. Physical examination and initial tests showed mild iron deficiency anemia, elevated C‐reactive protein, and normal vital signs. Chest radiograph revealed abnormalities in the left lower zone, leading to contrast‐enhanced chest CT. The CT scan revealed bilateral intrapulmonary sequestrations, both deriving blood supply from a common trunk originating from the celiac artery. The patient's symptoms initially attributed to a pulmonary infection improved with antibiotic therapy. Pulmonary sequestration is a congenital anomaly characterized by aberrant lung tissue lacking connections to bronchial tree or pulmonary arteries. It can lead to recurrent pulmonary infections and postinfectious sequelae. This case presented a unique bilateral sequestration, both originating from the celiac artery. Radiologists should be aware of sequestration types and associated anomalies, even in atypical locations. Blood supply can originate from various arteries, not just the aorta.