bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layerwise generalized formulation solved via a boundary discontinuous method for multilayered structures. Part 1: Plates
Authors: Laureano Ronaldo Walter , Mantari José Luis 
Published: January 2025

Abstract
This article presents for the very first time a layerwise bending analytical solution for cross-ply laminated composite plates with clamped boundary conditions at all edges. The displacement field is implemented within the framework of the Carrera unified formulation at a layer level by employing Legendre polynomials. The governing equations are obtained by using the principle of virtual displacements statement. This work utilizes the boundary-discontinuous double Fourier series to provide analytical solutions. The high accuracy of the proposed solution is demonstrated by comparing the results with three-dimensional finite-element model (FEM) solutions of multilayered and sandwich plates for various side-to-thickness ratios. In conclusion, the highly accurate proposed solution might be used as a benchmark problem for new analytical or FEMs.
Reliable, efficient, and scalable photonic inverse design empowered by physics-inspired deep learning
Authors: Shao Guocheng , Zhou Tiankuang , Yan Tao , Guo Yanchen , Zhao Yun , Huang Ruqi , Fang Lu 
Published: January 2025

Abstract
On-chip computing metasystems composed of multilayer metamaterials have the potential to become the next-generation computing hardware endowed with light-speed processing ability and low power consumption but are hindered by current design paradigms. To date, neither numerical nor analytical methods can balance efficiency and accuracy of the design process. To address the issue, a physics-inspired deep learning architecture termed electromagnetic neural network (EMNN) is proposed to enable an efficient, reliable, and flexible paradigm of inverse design. EMNN consists of two parts: EMNN Netlet serves as a local electromagnetic field solver; Huygens–Fresnel Stitch is used for concatenating local predictions. It can make direct, rapid, and accurate predictions of full-wave field based on input fields of arbitrary variations and structures of nonfixed size. With the aid of EMNN, we design computing metasystems that can perform handwritten digit recognition and speech command recognition. EMNN increases the design speed by 17,000 times than that of the analytical model and reduces the modeling error by two orders of magnitude compared to the numerical model. By integrating deep learning techniques with fundamental physical principle, EMNN manifests great interpretability and generalization ability beyond conventional networks. Additionally, it innovates a design paradigm that guarantees both high efficiency and high fidelity. Furthermore, the flexible paradigm can be applicable to the unprecedentedly challenging design of large-scale, high-degree-of-freedom, and functionally complex devices embodied by on-chip optical diffractive networks, so as to further promote the development of computing metasystems.
Involvement of aSPOC in the online updating of reach-to-grasp to mechanical perturbations of hand transport
Authors: Furmanek Mariusz P. , Schettino Luis F. , Yarossi Mathew , Mangalam Madhur , Lockwood Kyle , Adamovich Sergei V. , Tunik Eugene 
Published: January 2025

Humans adjust their movement to changing environments effortlessly via multisensory integration of the effector’s state, motor commands, and sensory feedback. It is postulated that frontoparietal (FP) networks are involved in the control of prehension, with dorsomedial (DM) and dorsolateral (DL) regions processing the reach and the grasp, respectively. This study tested (5F, 5M participants) the differential involvement of FP nodes (ventral premotor cortex - PMv, dorsal premotor cortex - PMd, anterior intraparietal sulcus - aIPS, and anterior superior parietal-occipital cortex - aSPOC) in online adjustments of reach-to-grasp coordination to mechanical perturbations that disrupted arm transport. We used event-related transcranial magnetic stimulation (TMS) to test whether the nodes of these pathways causally contribute to the processing of proprioceptive information when reaching for a virtual visual target at two different perturbation latencies. TMS over aSPOC selectively altered correction magnitude of arm transport during late perturbations, demonstrating that aSPOC processes proprioceptive inputs related to mechanical perturbations in a movement phase-dependent manner.Significance StatementDetailed knowledge regarding specific brain regions, the timing of their involvement, and roles in the online updating of sensory input during the control of the reach-to-grasp movement is critical for understanding the deficits resulting from various diseases, such as stroke, as well as for the development of effective intervention strategies. Our results provide evidence for the involvement of aSPOC in the modulation of the response to a mechanical perturbation of arm transport during the later stage of the movement, suggesting that this area participates in estimating the effector state based on proprioceptive input. Our results can provide key information for identifying brain targets of engagement in therapeutic applications of noninvasive brain stimulation to ameliorate motor deficits stemming from parietal damage.
Výraz vojna v korpusoch slovenského jazyka
Authors: Garabík Radovan , Wachtarczyková Jana 
Published: January 2025

V príspevku analyzujeme výskyt lexémy vojna v hlavných slovenských jazykových korpusoch. Zaujíma nás, ako a čím môžu korpusy prispieť k poznaniu jazykovej situácie v konkrétnom lingvokultúrnom priestore, aké informácie prinášajú a ako načrtávajú jazykový obraz sveta. Téma vojny za posledných 30 rokov nevystupovala v slovenskom prostredí do popredia, keďže populácia ju prevažne vnímala ako jav temporálne alebo geograficky vzdialený, teda niečo, čo priamo neovplyvňuje každodenný život.Zameriame sa na synchrónnu a diachrónnu analýzu v troch hlavných podkorpusoch Slovenského národného korpusu, publicistike, beletrii a odborných textoch, ako aj hovorenom korpuse slovenčiny. Ukazuje sa, že výskyt výrazu vojna a príbuzných lexém (napr. vojak, vojenský, vojnový) je vo webovom korpuse relatívne nízky a predpokladáme, že odráža bežnú jazykovú prax v slovenskom diskurze. Mierne vyšší výskyt je v publicistike a beletrii, pričom v korpuse odborných textov sa tento výraz objavuje ešte častejšie, čo je spôsobené prítomnosťou vedeckých a odborných publikácií z oblasti histórie. Všeobecný hovorený korpus má tiež podobný výskyt ako webový, ale v nahrávkach Ústavu pamäti národa má vojna výrazne vyšší výskyt. Ide o prirodzený odraz orálnej histórie a tzv. malých dejín, ktoré sú písané príbehmi jednotlivcov a pamätníkov historických udalosti (napr. SNP).Potvrdzuje sa, že dejiny spoločenstiev sú stále písané aj ako dejiny vojen. Pre diachrónnu analýzu sme preskúmali výskyty v niektorých časovo vymedzených korpusoch. V korpuse pokrývajúcom roky 1995 až 1989 je výskyt výrazu vojna výrazne vyšší. V skoršom období rokov 1843 až 1954 je však porovnateľný so súčasným bežným jazykom. Vďakaj anotácii Slovenského národného korpusu sme schopní analyzovať časovú závislosť frekvencie výskytu lexémy v rokoch 1955–2024. Očakávaný predpoklad poklesu týchto výskytov v závislosti od času sa potvrdil len čiastočne, najmä v odborných textoch, v dôsledku nárastu popularity iných vedných odborov. V beletrii a publicistických textoch sa v poslednom desaťročí frekvencia lexémy vojna značne zvýšila. V porovnaní s historickými textami z druhej polovice 19. storočia a prvej polovice 20. storočia sa moderné korpusy ani všeobecný hovorený korpus výrazne nelíšia.Do analýzy sme zaradili aj vektorové reprezentácie slov a ich vizualizáciu na skúmanie sémantických vzťahov slov. V slovenskom modeli má k výrazu vojna najbližšie spojenie vojnový konflikt a považujeme ho za kontextovú dominantu sémantického poľa pojmu vojna. Reflektujeme aj vektorový prenos z mužského rodu (vojak) do ženského rodu (vojačka). Napriek zjavnej veľmi veľkej rodovej nerovnosti v modernej armáde model nevykazuje rodovo zaujaté výsledky (nižšiu prestíž ženských variantov slov), ako to často vidíme v anglickojazyčných modeloch (v slovenských tento jav nebol potvrdený). Na záver ukazujeme možnosť použitia veľkého jazykového modelu na generovanie lexikografických definícií ako príklad možného budúceho smerovania lexikografie.
Зло и свободная воля
Authors: Гаспаров Игорь Гарибович 
Published: January 2025

В статье анализируются современные апологии от свободной воли, предложенные А. Плантингой, Р. Суинберном. Рассматриваемые авторы убеждены: существование мира, в котором есть свобода воли, является чем-то более ценным, чем существование мира, в котором свобода воли отсутствует. Показано, что в основании современных апологий от свободной воли лежит антропоморфная модель божества, согласно которой Бог мыслится как индивид среди прочих индивидов, хотя и наделенный своими качествами в превосходной степени, которая характерна для атеистических аргументов от зла. Также показано, что другой важный момент сходства между апологиями от свободной воли и атеистическими аргументами от зла заключается в том, что их сторонники пытаются оценить, каким бы был наш мир, если бы он был создан таким индивидом. В отличие от атеистических аргументов от зла современные апологии от свободной воли утверждают, что божественное всемогущество и всезнание являются ограниченными, особенно — желанием их обладателя дать некоторым из своих творений способность свободного выбора, которая логически предполагает возможность и даже необходимость существования зла. Продемонстрировано, что классический теизм не разделяет антропоморфную модель божества, характерную для многих современных философов религии. В концепциях классического теизма отвергается как антропоморфная модель божества, так и неподчиненность свободной воли Богу как высшему благу, а, напротив, предполагается, что свободное решение изначально является возможностью добровольного согласия человека с вложенным в него стремлением к Богу как высшему благу. Тем не менее в силу творения человека из ничего это согласие не может быть автоматическим — оно предполагает путь формирования добродетельного характера и переход человека от состояния, в котором он может не грешить, к состоянию, в котором он не может грешить.
Как два разума могут знать одну вещь
Authors: Джеймс Уильям , Сысоев Матвей Сергеевич 
Published: January 2025

Перевод текста: James W. How Two Minds Can Know One Thing // The Journal of Philosophy, Psychology and Scientific Methods. — 1905. — Vol. 2, no. 7. — P. 176–181.
Evaluating the influence of meteorological drought on river flow in the transboundary Sunkoshi basin, Nepal
Authors: Adhikari Tirtha Raj , Baniya Binod , Sharma Christina , Tang Qiuhong , Li He , Chen Deliang , Khadka Nitesh , Sigdel Madan , Awasthi Ram Prasad 
Published: January 2025

ABSTRACT

The transboundary Sun-Koshi River basin, characterized by intricate topography and geo-climatic diversity, has encountered distinct periods of droughts significantly impacting downstream river discharge. This study focuses on assessing temporal and spatial patterns of meteorological drought using SPI and SPEI indices, gauging their influence on river discharge through hydro-meteorological station data and the HEC–HMS model. Severe drought episodes were notably observed in 2010 and 2015. In 2010, prominent drought occurrences extended beyond Nepal's border into China. Conversely, in 2015, Jiri, Okhaldhunga, and Salleri experienced heightened drought conditions. Spatially, over 99% of the basin area experienced drought, varying from moderate to extreme magnitudes during 2010 and 2015. The estimated annual rainfall and basin outlet discharge were 1,800 mm, 1,907 mm, and 1,899 m3/s, 1,086 m3/s in 2010, and 2015, respectively. During drought periods, the stations indicated significantly reduced discharge, indicating a marked departure from normal conditions across the basin. Ultimately, station data performance and the HEC–HMS SCS curve number model showed that discharge in the Sunkoshi River basin is profoundly impacted by drought, notably influencing rainfall intensity on monthly, seasonal, and annual scales. The smaller basins discharge more accurate results compared to the larger outlet basins.
ZNF165: A Pan-Cancer Biomarker with Prognostic and Therapeutic Potential
Authors: Lyu Guizhen , Li Dongbing 
Published: January 2025

Background:
The role of ZNF165 in only a few tumors has been reported. ZNF165
plays an important role in liver cancer, gastric cancer, and breast cancer, especially in regulating
the immune microenvironment, promoting tumor cell proliferation and migration, and serving as a
potential target for immunotherapy.

Objective:
This study aimed to enhance an understanding of how the ZNF165 gene functions and
influences cancer development.

Methods:
Using a suite of online resources, including TIMER, TCGA, GTEx, GEPIA2, cBioPortal,
TIMER2, STRING, DAVID, RNAactDrug, CancerSEA, and UCSC, along with comprehensive
statistical analyses, we conducted a thorough investigation of the pan-cancer landscape of ZNF165.
This study encompassed an assessment of ZNF165 levels, their associations with patient outcomes,
and clinical correlates. We examined the interplay between ZNF165 and key cancer biomarkers,
such as Microsatellite Instability (MSI), Tumor Mutational Burden (TMB), immune cell
infiltration, and the expression of immune checkpoint genes. We delved into the genetic variations
of ZNF165, its biological roles across various cancer types, and its potential links to drug responsiveness.
We analyzed single-cell expression patterns of ZNF165 and their implications for the
functional dynamics of cancer. We employed quantitative Reverse Transcription PCR (qRT-PCR)
to measure ZNF165 levels in Ovarian Cancer (OC) cell lines.

Results:
ZNF165 expression displayed aberrations across a diverse range of human cancers and
exhibited correlations with clinical stages. High ZNF165 expression in KIRC, KIRP, STAD, and
UCEC was significantly associated with poor overall survival. ZNF165 has encouraging diagnostic
value in specific tumor types, with gene amplification identified as the predominant genetic alteration.
Our analysis further uncovered significant associations between ZNF165 levels and MSI
across three distinct cancer types, as well as with TMB in six different malignancies. We detected
substantial correlations between ZNF165 levels and immune cell infiltration, as well as the expression
of immune checkpoint genes. ZNF165 was found to be involved in several prevalent signaling
pathways across various cancer types. ZNF165 may potentially contribute to chemotherapy
and chemoresistance, and was observed to be involved in cancer progression. A ceRNA regulatory
network involving AFDN-DT, miR-191-5p, and ZNF165 was constructed for OC, revealing significantly
elevated ZNF165 levels in OC cell lines. Dysregulated ZNF165 expression across a
spectrum of malignancies might play a role in cancer initiation and advancement via multiple biological
pathways.

Conclusion:
ZNF165 may serve as a promising therapeutic target for the treatment of cancer in human
patients.
Phytosomes-unraveling the Unique Properties of Plant-derived Nanotechnological Drug Delivery Systems: A Review
Authors: Deniz Fatima Sezer Senol , Demiroz Fatma Nur Tugcu , Ulutas Onur Kenan , Erdogan Ilkay Orhan 
Published: January 2025

Abstract:
Phytosomes are innovative compounds that enhance the bioavailability of
plant-derived compounds, making them more effective in pharmaceuticals and nutraceuticals.
By improving cellular absorption, phytosomes allow lower doses of plant extracts
to achieve therapeutic effects, which may reduce both cost and the risk of potential side
effects. The incorporation of phospholipids in phytosomes not only stabilizes the active
compounds but also protects them from degradation in the gastrointestinal tract, potentially
increasing their shelf life and efficacy. Despite their promise, more clinical trials
are essential to fully validate the safety and therapeutic benefits of phytosomes. Ongoing
research and developments may lead to a better understanding of their mechanisms of action
and safety profiles and broaden their application in medicine.
Efficacy and Safety of Altibrain® as an Adjunctive Therapy for Autism Spectrum
Disorder: An Open Label Trial Targeting Core Symptoms
Authors: Mehan Sidharth , Kumar Aakash , Utage Prashant R. , Hegde Anaita , Naik Neeta , Kondekar Santosh , Yardi Nandan , Desai Neelu , Panigrahi Debasis , Chattopadhyay Arijit , Agarwal Sasmita Devi , Gupta Vineet Bhushan , Tiwari Ankita , Reddy Sai Chandar , Saraf Sandeep , Das Diptanshu , Detroja Mayank , Paliwal Charu 
Published: January 2025

Objective:
This study aimed to evaluate the effectiveness and safety of Altibrain® in combination
with standard Autism Spectrum Disorder (ASD) treatment compared to standard ASD treatment alone in individuals
diagnosed with ASD.

Method:
A randomized, open-label trial was conducted involving 120 participants aged 3 to 17 years, randomly
assigned to either the Standard ASD Treatment group or the Altibrain® + Standard ASD Treatment
group. Sixty patients were randomly allocated to each Standard ASD Treatment group or the Altibrain® +
Standard ASD Treatment group. participant allocation was done by computer-generated randomization. Participants
had confirmed ASD diagnoses based on DSM-IV or ICD-11 criteria and demonstrated moderate to
severe core ASD symptoms. Informed consent was obtained from caregivers. A total number of 120 subjects
were included, consisting of 71 male and 49 female patients. Participants received either standard ASD treatment
alone or Altibrain® in addition to standard ASD treatment orally once daily for 24 weeks. A total of 7
study visits/24 weeks to analyze the intervention efficacy of the Standard ASD Treatment group or the Altibrain
® + Standard ASD Treatment group. Primary outcomes included changes in core ASD symptoms measured
by the Autism Diagnostic Observation Schedule (ADOS) and safety assessments. Secondary outcomes
included alterations in social communication skills, reduction in repetitive behaviors, overall functional improvements,
and safety and tolerability of Altibrain®.

Results:
Altibrain® significantly improved qualitative deficits in social interaction and repetitive behaviors
compared to standard ASD treatment alone (p < 0.0001). The Altibrain® + Standard ASD Treatment group
demonstrated significant improvements in social functioning, social awareness, cognition, communication,
and motivation compared to the Standard ASD Treatment group (p < 0.0001). Additionally, Altibrain®
showed superior efficacy in reducing hyperactivity/noncompliance, inappropriate speech, irritability, lethargy/
social withdrawal, stereotypic behavior, and aberrant behavior compared to standard treatment alone (p <
0.0001). Additionally, Altibrain® exhibited a favorable safety profile as per the 4-week post-treatment safety
follow-up.

Conclusion:
Further research is warranted to confirm and expand upon these results, including longer-term
studies with larger cohorts and investigations into underlying mechanisms. Overall, Altibrain® holds promise
as a valuable therapeutic option for individuals with ASD and their families. Limitations of the study include
neuroimaging and biomarkers analysis.
Antiseizure Medications: Advancements, Challenges, and Prospects in Drug Development
Authors: Ng Yan Hong , Jamil Siti Nur Hidayah , Sarian Murni Nazira , Ahmed Qamar Uddin , Latip Jalifah , Lam Su Datt , Feroz Shevin Rizal 
Published: January 2025

Abstract:
Epilepsy is a neurological disorder affecting millions of people worldwide. Antiseizure
medications (ASM) remain a critical therapeutic intervention for treating epilepsy, notwithstanding
the rapid development of other therapies. There have been substantial advances in epilepsy medications
over the past three decades, with over 20 ASMs now available commercially. Here we describe
the conventional and unique mechanisms of action of ASMs, focusing on everolimus, cannabidiol,
cenobamate, fenfluramine, and ganaxolone, the five most recently marketed ASMs. Major obstacles
in the development of ASMs are also addressed, particularly drug-resistant epilepsy as well as psychiatric
and behavioral adverse effects of ASMs. Moreover, we delve into the mechanisms and comparative
efficacy of ASM polytherapy, with remarks on the benefits and challenges in their application
in clinical practice. In addition, the characteristics of the ideal ASM are outlined in this review.
The review also discusses the development of new potential ASMs, including modifying existing
ASMs to improve efficacy and tolerability. Furthermore, we expound on the modulation of γ-
aminobutyric acid type A receptor (GABAAR) as a strategy for the treatment of epilepsy and the
identification of a GABAAR agonist, isoguvacine, as a potential ASM.
Understanding the Relationship Between Care Quality Perception and Patient Safety Culture
Authors: Janghorban Ali , Moghri Javad , Ghavami Vahid , Raesi Rasoul , Tabatabaee Seyed Saeed 
Published: January 2025

Background
Assessing the perceived quality of care and safety culture by nurses is an important part of nursing practice and is vital for improving the quality of nursing care.

Aim
This study was conducted to investigate the relationship between perceived quality of care and patient safety culture.

Methods
A cross-sectional study was conducted using stratified and convenience sampling techniques from March 2023 to January 2024 among 412 nurses working in hospitals at Mashhad University of Medical Sciences, Iran. The data collection tools were standard care behavior questionnaires (CBI-42) and the Hospital Survey on Patient Safety Culture (HSOPSC). The data were analyzed using descriptive and inferential statistical tests at a significance level of 0.05.

Results
The perceived quality of care among nurses was high, with a score of 4.79 (1-6). The highest score was in “knowledge and professional skill” (5.03), while “communication and positive attitude” scored the lowest (4.59). Patient safety culture averaged 3.35 (1-5), with “overall perception of patient safety” at 4.82 and “non-punitive response to error” at 2.40. A significant direct relationship was found between perceived quality of care and patient safety culture (r=0.226, p<0.001), indicating that improvements in one may enhance the other.

Conclusion
Due to the existence of a direct relationship between perceived quality of care and patient safety culture, appropriate training and using the experiences of others, improving the relationship between nurses and patients, creating a sense of security in nurses, and solving the problems of nurses can enhance the quality of health care services.