bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological relaxation and increased working speed induced by volatile organic compounds emitted from interior walls made of Kagawa hinoki Japanese cypress (Chamaecyparis obtusa)
Authors: Kishida Fumi , Tani Kazuki , Nakashima Taisuke , Zennifa Fadilla , Isa Akiko , Fujimoto Noboru , Fujita Koki , Taki Ryuma , Yasutomi Hiroo , Yasumori Naotoshi , Shimizu Kuniyoshi 
Published: February 2024

Abstract

Since ancient times, Japanese cypress timber (Chamaecyparis obtusa; 'hinoki' in Japanese) has been highly valued in Japan. Because of its beautiful color and fragrance, this timber has been widely used as houses and furniture materials. Scientific evidence on the effect of the usage of hinokis' timber especially from Kagawa’s area as a building material toward human psychophysiological response has yet to be reported. The current study examined participants' psychophysiological responses to volatile organic compounds (VOCs) generated by hinoki interior walls growing in Kagawa Prefecture, Japan. This timber was reported to have a relaxing effect toward the participants, and this study discovered that inhaling air containing VOCs emitted by Kagawa hinoki interior walls increased parasympathetic nervous activity during resting periods between arithmetic tasks. When compared to a control condition, the participants' performance on a calculation test improved dramatically in the hinoki condition. These findings suggest that VOCs released by Kagawa hinoki walls influence the autonomic nervous system, emotions, and work performance. This study not only proved Kagawa hinoki fragrance's potential to boost human working speed, but it also newly confirmed the fragrance's ability to increase parasympathetic nervous system activity while at rest. This study also discovered that the enhanced working speed is caused by a part of the neurological underpinning for heightened arousal in the brain. As a result, this study concluded that the aroma of cypress can have physiological effects that change over time, hence optimizing individuals' behavior at work and at rest.
Design and characterization of geopolymer foams reinforced with Miscanthus x giganteus fibers
Authors: Walbrück Katharina , Witzleben Steffen , Stephan Dietmar 
Published: February 2024

Abstract

This paper presents the effects of different amounts of fibers and foaming agent, as well as different fiber sizes, on the mechanical and thermal properties of fly ash-based geopolymer foams reinforced with Miscanthus x giganteus fibers. The mechanical properties of the geopolymer foams were measured through compressive strength, and their thermal properties were characterized by thermal conductivity and X-ray micro-computed tomography. Furthermore, design of experiment (DoE) were used to optimize the thermal conductivity and compressive strength of Miscanthus x giganteus reinforced geopolymer foams. In addition, the microstructure was studied using X-ray diffraction (XRD), Field emission scanning electron microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR). Mixtures with a low thermal conductivity of 0.056 W (m K)−1 and a porosity of 79 vol% achieved a compressive strength of only 0.02 MPa. In comparison, mixtures with a thermal conductivity of 0.087 W (m K)−1 and a porosity of 58 vol% achieved a compressive strength of 0.45 MPa.
Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6+CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis
Authors: Zhou Ting , Lin Lan , Zhan Yawen , Zhang Ziyao , Jiang Ying , Wu Mi , Xue Dan , Chen Limin , Weng Xiufang , Huang Zhenghui 
Published: February 2024

Abstract
Background
The development of pulmonary fibrosis entails a cascade of events, where immune cell-mediated inflammation plays a central role. Chemotherapeutic drugs have been observed to exert dual impacts on fibrosis, with bleomycin exacerbating pulmonary fibrosis and bortezomib alleviating tissue fibrotic processing. Understanding of the complex interactions between chemotherapeutic drugs, immune responses, and pulmonary fibrosis is likely to serve as the foundation for crafting tailored therapeutic strategies.
Methods
A bleomycin-induced pulmonary fibrosis model was established, followed by bortezomib treatment. Tissue samples were collected for immune cell subset analysis and functional evaluation through flow cytometry and in vitro cell experiments. Additionally, multi-omics analysis was conducted to further elucidate the expression of chemokines and chemokine receptors and the characteristics of cell populations.
Result
Here, we noticed that CXCL16 and CXCR6 were elevated in the lung tissue of pulmonary fibrosis model. In the context of pulmonary fibrosis or in vitro TGF-β1 stimulation, macrophages exhibited M2-polarized phenotype and secreted more CXCL16 compared with control group. In addition, flow cytometry revealed that pulmonary CD4 T cells expressed higher CD69 and CXCR6 levels in fibrosis progress. Upon administration of bortezomib, bleomycin-induced pulmonary fibrosis was alleviated accompanied by decreased M2-polarized macrophages and reduced accumulation of CXCR6-expressing CD4 T cells.
Conclusions
Our findings provide insights into the key immune players in bleomycin-induced pulmonary fibrosis and offer the preclinical evidence supporting the repurposing strategy and combination approach to reduced lung fibrosis.
Risk of stress cardiomyopathy associated with selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors: A real-world pharmacovigilance analysis
Authors: Tan Boyu , Chen Li , Yan Sulan , Pan Huijie , Zhang Jingxian , hongyan wei 
Published: February 2024

Abstract
Objective
Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are the two commonly prescribed antidepressants, but these drugs have been reported clinically to cause stress cardiomyopathy (SC). This study aimed to evaluate the possible association between SSRI or SNRI usage and the occurrence of cardiomyopathy by mining the publicly available U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Methods
The disproportionate analysis and likelihood ratio test were employed to identify risk signals associated with the use of SSRIs or SNRIs and the incidence of stress cardiomyopathy. The raw data was sourced from the FAERS database from 2012 to 2022. Descriptive statistics were further applied to present the demographic characteristics, time to onset, concomitant medications and prognostic outcomes. Statistical analysis and data visualization were conducted using the R v4.0.2.
Results
In total, 132 individual case safety reports (ICSRs) of SC associated with SSRIs or SNRIs were identified. Venlafaxine and fluoxetine were identified as the most commonly suspected antidepressant medications, accounting for 48% and 27% of the ICSRs, respectively. Approximately 80% of SC cases were reported in females, with individuals aged 45–65 identified as a high-risk population. The reporting regions were mainly in Europe and North America, with differences in antidepressant utilization preferences between geographic regions. Both venlafaxine (RSIC 2.54, 95%CI 2.06 to 3.04) and fluoxetine (RSIC 3.20, 95%CI 2.31 to 4.47) exhibited a significant disproportionality of SC, with likelihood ratio estimates of 3.55 (p = 0.02) for venlafaxine and 4.82 (p = 0.008) for fluoxetine. Propofol, lidocaine, oxycodone, gabapentin and zonisamide were the frequently co-administered with SSRIs or SNRIs. The median time to cardiomyopathy onset was 20 days. The most frequently reported outcomes were hospitalization or prolonged hospitalization in 48.33% of patients, and other serious events occurred in 12% of patients.
Conclusion
This analysis based on the FAERS database provided new insight into the main characteristics of adverse cardiomyopathic events associated with SSRIs and SNRIs in real-world. The risk of cardiomyopathy varied between SSRIs and SNRIs, and there was a significant disproportionate risk signal associated with stress cardiomyopathy, particularly in middle-aged women for venlafaxine and fluoxetine. Caution should be exercised when SSRIs or SNRIs are used with other serotonergic medications.
WITHDRAWN: Study on prevalence, risk factors and clinical phenotypic appraisals of Theileria annulata infection in Gir cattle
Authors: Parmar Vijay L. , Vagh A. A. , Patel U. D. , Bilwal A. K. , Thakre B. J. , Brahmbhatt N. N. , Patbandha Tapaskumar , Parmar J. N. 
Published: February 2024

Abstract
Background:Theileria annulata is responsible for tropical bovine theileriosis, which hasa significant impact on cattle health and leadsto remarkable economic losses to the dairy industry in India. In the present study, 702 Gir cattle were screened for Theileria annulata infection viatraditional microscopic and molecular techniques. The prevalence of the disease in relation to age, gender, season, tick infestations, and the frequency of acaricidal treatment in infected animals was assessed by the chi-square test, and potential risk factors were explored through multivariatelogistic regression. Additionally, a thorough clinical examination of each infected animal was performedto document clinical markers.
Results: The overall prevalence of T. annulata infection in Gir animals was37.46%. Among Gir cattle, the prevalence and risk of disease was significantly greaterin the >5 year age group (57.73%; P=0.001, OR=5.19, 95% CI = 3.504-9.996), during the summer season (49.08%; P=0.001, OR=3.19, 95% CI = 2.096-4.878), with tick infestation (58.58%; P=0.001, OR=6.5, 95% CI = 4.609-9.183) and significantly lower in animals with regular acaricidal application (6.98%; P=0.001, OR=0.04, 95% CI = 0.022-0.091). Pyrexia, lymphadenopathy, altered appetite, ocular and nasal discharge, pale mucous membrane, and tick infestations are considered important clinical appraisals.
Conclusions: The prevalence and risk of T. annulata infection were greater in addition to the variation in clinical markers in the Junagadh region, suggesting that further research is needed to explore the epidemiological status of this disease in the western region of Gujarat in Gir to develop effective preventive measures.
Classifying Students' Grounded Mental Models on Energy with Deep Neural Network
Authors: Yaz Ömer Volkan , Kurnaz Mehmet Altan , Karacı Abdulkadir 
Published: February 2024

Abstract
The concept of energy, a common interdisciplinary concept, is frequently used in daily life and can be associated with different subjects in terms of its scope. Additionally, it has an important place in science education, throughout primary, secondary and higher education. Thus, many grueling applications are carried out to detect learning situations. However, in recent years, opportunities have emerged to determine learning situations with deep learning networks (DNNs), which are a subunit of artificial intelligence. This study aimed to demonstrate the usability of DNNs in the classification of learning and to establish an example in this field of educational research concerning the concept of energy. To this end, a learning situation test was used to evaluate “energy types”, “transformation of energy” and “conservation of energy” to determine the “grounded mental model” (GMM). The test was used to determine the GMM of preservice teachers and to test the classification success with the least error by using a DNN. In this context, DNN models consisting of different parameters were designed for the training of deep neural networks. The models were analyzed with the most appropriate algorithm considering the number of hidden layers, the number of neurons in the hidden layers, the activation function, the optimization algorithm, the loss function, and the epoch values. Two methods were used for training and testing the ensemble classifiers and individual classifiers. The first is to divide the dataset into 70% training data and 30% test data, and the second is a 5-fold cross-validation method. The results were evaluated using the recall (R), specificity (S), accuracy (ACC), and F1 score metrics. According to the test results obtained from both methods, the ensemble classifier has the best classification performance. According to the results of the analysis with deep neural network algorithms, 95% classification accuracy was obtained. Trainers can use the designed DNN models as a validation tool in the detection of GMM.
Relationship between sexual function and marital satisfaction with quality of life-related gestational diabetes mellitus: a cross-sectional study
Authors: Nazarpour Soheila , Simbar Masoumeh , Kiani Zahra , Khalaji Neda , Khargh Mobina Khorrami 
Published: February 2024

Abstract
Background: Sexual dysfunction is a common problem among women with Gestational Diabetes Mellitus (GDM) that may affect the women’s quality of life (QoL). This study aimed to assess the relationship between women’s sexual function and marital satisfaction with GDM-related quality of life and its dimensions.
Method: This was a cross-sectional study of 168 women with GDM. The participants were recruited using a multi-stage sampling method from the maternal care centers affiliated with Shahid Beheshti University of Medical Sciences in Tehran-Iran. The data were collected using a socio-demographic questionnaire, the standard GDM-related quality of life questionnaire (GDMQoL-36), the Female Sexual Function Index (FSFI), and the Enrich's Marital Satisfaction questionnaire. The data were analyzed by using SPSS-23 software and statistical tests such as Pearson and Spearman correlation coefficient, t-test, ANOVA, and multiple linear regression.
Results: The average women’s age and the gestational age were 31.79±6.64 years and 30.73±6.11 weeks, respectively. The average scores for GDMQoL, FSFI, and marital satisfaction were 55.43±8.67 (ranging 0-100), 19.95±11.43, and 34.45±9.13, respectively. Female Sexual dysfunction (FSD) was observed in 62.5 percent of the participants. The total score of GDMQoL and the “Perceived constraints” dimension had a significant positive correlation with the total score of FSFI and its all domains. There were also significant positive correlations between the total score of GDMQoL with Enrich's marital satisfaction. Furthermore, there was a significant relationship between the total score of GDMQoL with age, weight, duration of marriage, adequacy of monthly income, husband's occupation, and history of GDM. Multiple linear regression revealed that sexual function and marital satisfaction are the potential predictors of GDMQoL.
Conclusion: Sexual function and marital satisfaction are related to the GDM-related quality of life of women. Therefore, improving sexual function and marital satisfaction should be considered for improving GDM-related quality of life in health care policies.
The catheter flushing method increases the diagnostic yield of brushing cytology for biliary strictures
Authors: Jang Sung Ill , Sung Min Je , Nahm Ji Hae , Jeong Seok , Lee Tae Hoon , Kwon Chang-Il , Kim Dong Uk , Lee See Young , Cho Jae Hee 
Published: February 2024

Abstract

Background and Aim: Endobiliary brushing is usually performed in the diagnosis of indeterminate biliary strictures; however, in this setting, brush cytology is limited by a low diagnostic yield and sensitivity. Here, we evaluated whether the catheter flushing method (CFM) could improve cellularity and diagnostic performance compared with the conventional cytologic method (CCM).
Methods: Endobiliary brushings were obtained during endoscopic retrograde cholangiopancreatography (ERCP) from patients with biliary strictures enrolled at six tertiary hospitals. Additional CFM was performed after brushing. Using liquid-based cytologic preparations of samples, we assessed the diagnostic performance of the CCM using Pap staining and the CFM using methionyl-transfer RNA synthetase 1 (MARS1) immunofluorescence staining.
Results: From a total of 399 patients (malignant, 253; benign, 146), 374 CCM samples and 361 CFM samples contained adequate cells, with no significant difference in diagnostic yield (93.7% vs. 90.5%, respectively, P = 0.721). The sensitivity of the CFM (90.3%) was significantly higher than that of the CCM (75.1%; P < 0.001), with no significant difference in accuracy between methods (81.2% vs. 82.6%, respectively; P = 0.608).
Conclusions: Diagnostic yield was equivalent between CCM and CFM. Also, the high sensitivity and similar accuracy of the CFM compared with the CCM indicates that the CFM could be an additional brush cytology method for detecting malignancy in patients with indeterminant biliary strictures. Further prospective studies are needed to validate these findings.
D-mannose suppresses the angiogenesis and progression of colorectal cancer
Authors: Du Yu , Zhang Xinchao , Xu Yixin , Zhou Yuefan , Xu Yanping 
Published: February 2024

Abstract
Angiogenesis is an important factor influencing the development of solid tumors, and vascular endothelial growth factor receptor-2 (VEGFR2) is a central regulator of angiogenesis. Antibodies and inhibitors against VEGFR2 have been widely used in various malignancies. However, the regulatory mechanism of VEGFR2 has not been fully clarified. Here, we show that D-mannose can significantly inhibit angiogenesis and tumor growth by degrading VEGFR2. Specifically, D-mannose inactivates GSK3β by promoting the phosphorylation of GSK3β at Ser9, enhances nuclear translocation of TFE3, and promotes lysosomal biogenesis, thereby increasing lysosomal-mediated degradation of VEGFR2. Thus, D-mannose significantly suppressed proliferation, migration and capillary formation of human umbilical vein endothelial cells (HUVEC) in vitro. Oral administration of D-mannose dramatically inhibited angiogenesis and tumor growth in mice. Our findings reveal a previously unrecognized anti-tumor mechanism of D-mannose by destabilizing VEGFR2 and provide a new strategy for clinical treatment of colorectal cancer (CRC).
A case report of Implantable Collamer Lens removal with cataract extraction and TECNIS Symfony extended range of vision intraocular lens (ZXR00) implantation
Authors: Yue Peilin , Li Enjie , Wang Zhenyu , Song Xudong 
Published: February 2024

Abstract
Background One of the most common reasons for patients to have a second operation to remove the implantable collamer lens (ICL) is anterior subcapsular cataract (ASC), which is also one of the major problems following ICL implantation. Nonetheless, it is still unclear if patients with high myopia can benefit from contemporaneous ICL removal, cataract extraction and multifocal intraocular lens (MIOL) implantation in terms of their visual outcomes.
Case presentation A 39-year-old male highly myopic patient who underwent concurrent ICL removal, cataract extraction, and TECNIS Symfony ZXR00 IOL implantation in both eyes is reported in this case. Surgeons organize the surgery taking into account the patient's strong desire for freedom from spectacles, the needs for everyday vision, and the features of the chosen IOL. Enhanced biological measurement devices, such us Pentacam and IOL Master 700, were used to get accurate parameters. The IOL power was calculated using the Barrett True-K formula, thereby allowing a residual refraction of -0.50D to -0.75D to match patient’s demand. The surgeries were performed on the right and left eyes with a 2-week interval. A comprehensive evaluation of the patient's visual outcomes was conducted at the 3-month follow-up using manifest refraction, anterior segment OCT (Casia2), defocus curve, OPD-Scan III, and NEI-VFQ-14. The patient demonstrated excellent near and intermediate vision as well as overall visual quality, with high satisfaction.
Conclusion For patients with ASC requiring surgery after ICL implantation, and with a strong desire for spectacle independence and specific occupational demands, the use of TECNIS Symfony ZXR00 IOL, along with adjustments to the residual refractive power, may result in outstanding visual quality and patient satisfaction.
The Fractional Exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma
Authors: Kaya Tuba , Braunstahl Gert-Jan , Veen Johannes in 't , Valk Johanna van der 
Published: February 2024

Abstract
Background Asthma is a common disease characterized by chronic inflammation of the lower airways, bronchial hyperactivity, and (reversible) airway obstruction. The Global Initiative of Asthma Guideline recommends a flowchart to diagnose asthma with first-step spirometry with reversibility and a bronchial challenge test (BPT) with histamine or methacholine as a second step. The BPT is considered burdensome, time-consuming for patients and staff, can cause side effects, and is expensive. In addition, this test strongly encumbers lung function capacity. Elevated Nitric Oxide (NO) is associated with airway eosinophilic inflammation in asthma patients and can be measured in exhaled air with the Fractional exhaled (Fe) NO-test. This low-burden FeNO-test could be used as an ‘add-on’ test in asthma diagnostics.
Methods and analysis This multi-center prospective study (Trial number: NCT06230458) compares the ‘standard asthma diagnostic work-up’ (spirometry with reversibility and BPT) to the ‘new asthma diagnostics work-up’ (FeNO-test as an intermediate step between the spirometry with reversibility and the BPT), intending to determine the impact of the FeNO-based strategy, in terms of the number of avoided BPTs, cost-effectiveness and reduced burden to the patient and health care. The cost reduction of incorporating the FeNO-test in the new diagnostic algorithm will be established by the number of theoretically avoided BPT. The decrease in burden will be studied by calculating differences in the Visual Analogue Scale (VAS) -score and Asthma Quality of Life Questionnaire (AQLQ) -score after the BPT and FeNO-test with an independent T-test. The accuracy of the FeNO-test will be calculated by comparing the FeNO-test outcomes to the (gold standard) BPTs outcomes in terms of sensitivity and specificity. The intention is to include 171 patients.
Ethics and dissemination The local medical ethics committee approved the proposed study and is considered a low-burden and risk-low study. The local medical ethics committee registration number: R23.005.