bluuebunny/crossref_metadata_2025_split huggingface dataset:
A FOCUS-PDCA quality improvement model to reduce perioperative analgesic pump residuals
Authors: Xiang Yun , Wu Jimin , Xu Qiaomin , Duan Gongchen , Lan Haiyan , Ai Mengting , Sun Min , Li Xiaofen 
Published: January 2024

Abstract

The aim of this study was to investigate the effectiveness of applying the FOCUS-PDCA quality improvement model in reducing the perioperative analgesic pump surplus. We applied the FOCUS-PDCA quality improvement model to analyse the causes of perioperative analgesic pump residuals, then developed an improvement strategy and compared residuals before and after implementation. After the implementation of the FOCUS-PDCA quality improvement model, the abandonment rate of analgesic pumps decreased from 31.35% to 9.72%, and the total amount of residual volume decreased from 12,350 ml to 4,356.9 ml. Therefore, Thus, the FOCUS-PDCA quality improvement model succeeded in significantly reducing the perioperative analgesic pumps residuals and guaranteeing the quality of medical safety of perioperative analgesic pumps.
Hot topics of concern for married men: the correlation between male sexual function and vasectomy
Authors: Yu Xujun , Chen Diang , Wang Meijing , Lan Xiucheng , Fang Chunyan , Li Junjun , Dong Liang , Chang Degui , Yang Fang 
Published: January 2024

Abstract
A considerable number of male patients express apprehension regarding the potential correlation between vasectomy and sexual functionality, and worrying about affecting the couple's quality of sexual life and causing anxiety and depression. We investigated 306 male patients who sought vasectomy surgery between March 2016 and February 2022 at the Reproductive Women and Children's Hospital affiliated with Chengdu University of Traditional Chinese Medicine. We assessed patients' postoperative erectile status, ejaculation status, and depression and anxiety mainly by means of rating scales, including International Index of Erectile Function-5 (IIEF-5), the Chinese Index of Premature Ejaculation (CIPE), Zungs Self-Rating Depression Scale (SDS), and Self-Rating Anxiety Scale (SAS). Descriptive statistics (t-test, analysis of variance, rank sum test) detail the effect of vasectomy on IIEF-5, CIPE, SDS, SAS in men of different age groups.The results of age analysis showed that IIEF-5 and CIPE scores improved before and after ligation in different age groups (P < 0.05), with IIEF-5 scores improving the most in the age range of 30–39 years (205, 66.34%) (P = 0.00);Vasectomy does not affect male sexual satisfaction or erections, increases male patients' sexual confidence and desire, and does not cause or increase anxiety or depressive symptoms in men.
Banking for Old Age: Quality of Life and Health Care Time Banking Decisions in China
Authors: Hao Jiaozhi , Zhang Anqi , Leng Anli , Maitland Elizabeth , Nicholas Stephen , Wang Jian 
Published: January 2024

Abstract
Background
In China, time banking is an innovative form of mutual healthcare for older adults and a new approach to respond to an aging population. Quality of life is a comprehensive indicator of a person’s health status, but empirical evidence on how the quality of life impacts older people’s willingness to participate in time banking is lacking. This paper examines the impact of physical and mental quality of life on Chinese older adults’ willingness to participate in health care time banking.
Methods
Employing nationally representative data collected from 2147 respondents across 12 Chinese provinces, a linear probability model analyzed the relationship between quality of life and willingness for older people to participate in time banking, and robustness tests were conducted using logit and probit models.
Results
Fifty-eight (58%) percent of older adults were willing to participate in a volunteer time banking program. There was a significant positive correlation between physical quality of life and willingness of older adults to participate in time banking. Mental quality of life had a significant negative correlation with older adults’ time banking engagement decisions. Females, urban residents and the youngest older adults were more likely to participate in time banking.
Conclusions
Government should expand time banking; carry out time banking health promotion activities with different messages for females versus males, urban versus rural residents and physical QoL versus mental QoL residents; segment the target audiences by age; and through care time banking campaigns promote public social responsibility and support for China’s aging population.
Genetic architecture of root growth angle, seminal root numbers and early vigor in the synthetic hexaploid wheat diversity panel
Authors: Khalid Maria , Ahmad Zubair , Ahmed Suhaib , Maqbool Saman , Gul Alvina , Aamir Rabia , Khan Adeel Hassan , Mahmood Zahid , Hickey Lee , Rasheed Awais 
Published: January 2024

Abstract
Drought is a serious threat to crop production threatening food security worldwide. Seminal root growth angle (RA) and root number (RN) are important components of root system architecture (RSA) for the adaptability of plants under water stress. Likewise, leaf area (LA) in early vigor contributes against unpredictable drought stress. We characterized a collection of synthetic hexaploid wheat for root angle, seminal root numbers, and early vigor and identified loci associated with these traits using a 50K SNP array and genotyping-by-sequencing (GBS) platforms. LA showed a negative correlation with RN and a poor correlation with RA. In total, 39 marker-trait nucleotides (QTNs) were associated with LA, RA, and RN distributed over 10 wheat chromosomes. Out of these, 11 QTNs were associated with LA, 15 QTNs were associated with RA, and 13 QTNs were associated with RN. The higher frequency of favorable alleles in some synthetic hexaploid wheat accessions increased the phenotypic values and such synthetic wheats could be prioritized in wheat breeding to improve RSA and early vigor. These initial findings could be helpful for pre-breeding to improve wheat adaptability under drought stress conditions.
Enhanced recombination empowers the detection and mapping of Quantitative Trait Loci
Authors: Mercier Raphael , Capilla-Pérez Laia , Solier Victor , Gibault Elodie , Lian Qichao , Goel Manish , Hüttel Bruno , Keurentjes Joost , Loudet Olivier 
Published: January 2024

Abstract
Modern plant breeding, such as genomic selection and gene editing, is based on the knowledge of the genetic architecture of desired traits. Quantitative trait loci (QTL) analysis, which combines high throughput phenotyping and genotyping of segregating populations, is a powerful tool to identify these genetic determinants. However, meiotic recombination, which is the source of the genetic variation, is limited with typically only one to two crossovers per chromosome. Here we tested the effect on QTL analysis of boosting recombination, by mutating the anti-crossover factors RECQ4 and FIGL1 in Arabidopsis thaliana hybrids and substitution lines. We showed that increasing recombination ~6-fold empowers the detection and resolution of QTLs, reaching the gene scale with only a few hundred plants. Further, enhanced recombination unmasks some secondary QTLs undetected under normal recombination. These results show the benefits of enhanced recombination to decipher the genetic bases of traits.
Fertilization, irrigation and pasture sown to improve herbage production and quality in Nothofagus antarctica silvopastoral systems in southern Patagonia
Authors: Gargaglione Veronica , Peri Pablo Luis , Mayo Juan Pablo , Christiansen Rodolfo 
Published: January 2024

Abstract

Nothofaus antarctica forest extends from 46 to 56º SL been used as silvopastoral systems (SSP). Several studies have characterized understory of N. antarctica SSP. However, other practices like pasture sawn, irrigation and fertilization, to improve understory yield, remains undocumented. The aim of this work was to compare dry matter (DM) production and quality of natural understory vs. implanted pastures under different water and nutrient conditions. An experiment with fifteen plots of 6x 6 m where randomly established in a split-split plot design with specie as the main factor, water as the sub-plot factor and fertilizer application level as sub-sub-plot factor. The species evaluated were: Dactylis glomerata, Bromus catharticus, Trifolium pratense, T. repens and natural understory. Total dry matter (DM) production, leaf N concentration and digestibility were measured after one and two years of experiment establishment. Significant differences were found in DM according to specie, water and fertilization treatment. The highest DM production was for D. glomerata with irrigation and 100 kg N ha− 1 (6347 kg DM ha− 1), followed by natural understory with irrigation and 200 kg N ha− 1 and T. pratense with irrigation after the first year. In contrast, after two years, significant differences were found only for specie and fertilizer treatments where the highest yield corresponded to T. pratense pasture. For quality T. repens had the highest digestibility values. This study showed that pure pastures of D. glomerata accompanied by N fertilization or T. pratense, are viable options to increase forage yield and quality in N. antarctica SSP.
Effect of Electroacupuncture Intervention on Postoperative Pain in Patients Receiving Shoulder Arthroscopic Surgery: Study Protocol for A Non-inferiority Randomized Controlled Trial
Authors: Duan Panpan , Hu Jiamin , Yang Tao , Li Yan , Wang Xin , Chen Jiahui , Xu Weidong , Tong Wenwen , Xu Yihong , You Yanli , Ni Liya 
Published: January 2024

Abstract
Purpose: Shoulder arthroscopy , as a minimally invasive surgical technique for patients who have shoulder injuries, has the advantages of short inpatient period and fast postoperative recovery. However, Patients experienced surgery have a common symptoms : postoperative pain . Which can delay rehabilitation and influence the result of treatment . Although there are many managements for pain after shoulder arthroscopy surgery, the adherence rate of interventions remains low, and adverse effects often occur. Electroacupuncture is a traditional Chinese medicine treatment which is used to alleviate pain after surgery by inhibiting the functional connection between cerebellum and cortex thalamus in a large number of clinical studies. Therefore, this study aims to explore the effect of electroacupuncture on postoperative pain in patients receiving shoulder arthroscopic.
Methods and Analysis: This is a single-center, non-inferiority, randomized, single-blind, placebo-controlled trial. This trial aims to evaluate the efficacy and safety of electroacupuncture for analgesia in patients receiving arthroscopic shoulder surgery. 120 patients receiving rotator cuff repair under shoulder arthroscopy will be recruited. They will be randomly divided into an acupuncture analgesia group (patients receive electroacupuncture analgesia and intravenous patient controlled analgesia with 0.9% saline after surgery) and an intravenous analgesia group (patients receive sham electroacupuncture and intravenous patient controlled analgesia with analgesic drugs). The main outcome is postoperative pain score. The secondary outcomes are the patients’ postoperative analgesic requirements, levels of inflammatory factors before and after acupuncture, patient satisfaction, postoperative complications, incidence of delirium, sleep quality, and shoulder joint function rehabilitation.
Discussion: This study will be the first time to explore the effect and safety of electroacupuncture on postoperative shoulder pain as a clinical trial. Our finding will provide a new insight to alleviate pain after shoulder surgery.
Trial registration: This research was registered at the China Clinical Trials Registry. The registration number is ChiCTR2300068773.
Robotic Resection of Presacral Tumors
Authors: Ferrari Davide , Violante Tommaso , Addison Poppy , Perry William R.G. , Merchea Amit , Kelley Scott R. , Mathis Kellie L. , Dozois Eric J. , Larson David W. 
Published: January 2024

Abstract

Background:Presacral tumors are a rare entity typically treated with an open surgical approach. A limited number of minimally invasive resections have been described. Aim of the study was to evaluate the safety and efficacy of robotic resection of presacral tumors.
Methods: This was a retrospective single system analysis, conducted at a quaternary referral academic healthcare system, and included all patients who underwent a robotic excision of a presacral tumor between 2015 and 2023. Outcomes of interest were operative time, estimated blood loss, complications, length of stay, margin status, and recurrence rates.
Results: Sixteen patients (11 females, 5 males) were included. Median age of the cohort was 51 years (range 25-69). Median operative time was 197 minutes (range 98-802). Median estimated blood loss was 40 ml, ranging from 0 to 1800 ml, with one patient experiencing conversion to open surgery after uncontrolled hemorrhage. Urinary retention was the only post-operative complication that occurred in 3 patients (19%) and was solved within 30 days in all cases. Median length of stay was one day (range 1-6). Median follow-up was 6.7 months (range 1-110). All tumors were excised with appropriate margins, but one benign and one malignant tumor recurred (12.5%). Ten tumors were classified as congenital (one was malignant), two were mesenchymal (both malignant), and five were miscellaneous (one malignant).
Conclusions:Robotic resection of select presacral pathology is feasible and safe. Further studies must be conducted to determine complication rates, outcomes, and long-term safety profiles.
The Prognostic Significance of Tertiary Lymphoid Structure Assessment with Hematoxylin and Eosin Sections in Esophageal Squamous Cell Carcinoma
Authors: Liang YinFeng , Wang Zhizhong , Sun Rui , Wang Dongqing , Zhao Jiuzhou , Wang Bo , Miao JinXin , Guo Yongjun 
Published: January 2024

Abstract
Purpose To explore the potential prognostic prediction values of tertiary lymphoid structure (TLS) assessed using hematoxylin-eosin staining sections in esophageal squamous cell carcinoma（ESCC）
Methods We conducted a comprehensive study involving 87 patients diagnosed with ESCC. Relevant clinicopathological data were collected. HE staining was performed to investigate the presence, density, diameter, and distribution of TLS within the cancerous regions. Subsequently, survival analysis using Kaplan–Meier and multivariable Cox regression analysis was executed to assess the prognostic significance of TLS profiles in ESCC patients. To corroborate our findings, we validated the results in an additional dataset comprising 84 ESCC patients obtained from the TCGA repository.
Results We detected tertiary lymphoid structures (TLS) in 58 out of the 87 collected ESCC patients, mirroring the TCGA dataset where 44 out of 84 patients displayed TLS. The presence of TLS, coupled with their average density, diameter and distribution, demonstrated a correlation with prolonged survival in ESCC patients. However, upon adjusting for pathologic features, only the presence status of TLS emerged as an independent prognostic factor for long-term survival in ESCC, yielding a hazard ratio of 0.432 (P = 0.004). This observation was substantiated in the TCGA dataset with a hazard ratio of 0.359 (P = 0.028). This finding was validated in the TCGA data set with of hazard ratio of 0.359 (P = 0.028)
Conclusion The routine evaluation of TLS presence in ESCC with HE staining appears to be feasible and could serve as an efficient biomarker for prognostic prediction.
Omentin-1: A Potential Biomarker and therapeutic agent for Diabetic Chronic Kidney Disease
Authors: Chaudhari Mohammed Juned Ahmed , Vasanthan M. Vasanthan M. , Vinodhini V.M.Vinodhini V.M. , B Prathap Ranen Roy B Prathap Ranen Roy , R Shri Namrutha R Shri Namrutha , Choudhary Sahil Ahmed Choudhary Sahil Ahmed , Ray Soumili Ray Soumili , M Poornathitya M Poornathitya 
Published: January 2024

Abstract

Background
Recent studies revealed that patients with type 2 diabetes mellitus (T2DM) have an increased risk of developing chronic kidney disease (CKD), also known as diabetes-related chronic disease, which increases morbidity and mortality. Diabetes-associated CKD is a complex degenerative disorder linked to oxidative stress and inflammation induced by elevated blood sugar levels (hyperglycemia). Hyperglycemia promotes the production of free radicals, leading to oxidative stress, a significant contributor to the pathogenesis and advancement of diabetes-associated CKD. Therefore, a strategic approach involves the identification and development of innovative therapeutic alternatives that precisely target the signaling pathways of oxidative stress and inflammatory cytokines to prevent the rapid prevalence of diabetes-associated CKD. One such adipokine that fulfills the above requirements is omentin-1. Omentin-1,313 amino acids Adipokine is known to have an anti-inflammatory effect. It is expressed primarily in visceral fat tissue and is found to enhance insulin signaling.
Methods
This case-control study was conducted at SRM Medial College Hospital and Research Centre, India. Study population was 60 diabetic kidney disease and 60 normal healthy subject. After the selection of the study population, the following data were collected: anthropometric measurement, serum creatinine, urea, BUN, eGFR, total cholesterol, triglycerides, LDL-c, VLDL-c, and HDL-c. Appropriate statistical tests were applied.
Result
The mean value of omentin-1 in cases was 1.0675 ± 0.416 ng/ml, which was significantly lower than controls 1.4225 ± 0.737 ng/ml (P = 0.0015*). This result justifies that omentin has a significant relationship with renal damage. The mean value of hs-CRP in cases was 12.716 ± 5.04 mg/L, which was significantly higher than controls 8.289 ± 5.36 mg/L (P = 0.000029*). This result justifies that hs-CRP has a significant relationship with renal damage. Omentin-1 was found to have a significant positive correlation with eGFR (r = 0.279**, P = 0.002); however, no significant correlation was found between omentin-1 and hs-CRP (r = -0.043, P = 0.639). This result suggests that omentin-1 is notably associated with renal damage and could serve as an independent anti-inflammatory marker for diabetes-related chronic kidney disease (CKD).
Conclusion
Significantly decreased omentin-1 levels in diabetes-associated CKD subjects as compared to control subjects were demonstrated in this study. Thus, omentin-1 may be considered as independent anti-inflammatory predictive marker for the diagnosis and monitoring of diabetes-associated CKD.
A two-stage stochastic programming for the integrated emergency mobility facility allocation and road network design under uncertainty
Authors: Huatian Gong , Xiaoguang Yang 
Published: January 2024

Abstract

Emergency Mobility Facilities (EMFs) possess the capability to dynamically relocate, providing effective responses to fluctuations in emergent demand patterns across temporal and spatial dimensions. This study proposes a two-stage stochastic programming model that integrates the EMF allocation problem and the road network design problem for disaster preparedness. The model takes into account uncertainties arising from emergency demand and road network congestion levels under various sizes and timings of disaster occurrences. The first-stage decision involves determining the fleet size of EMFs and identifying which road links' travel time to reduce. The second-stage decision pertains to the routing and schedule of each EMF for each disaster scenario. Due to the intricate nature of this problem, the resulting model takes the form of a non-convex mixed-integer nonlinear program (MINLP). This poses computational challenges due to the inclusion of bilinear terms, implicit expressions, and the double-layered structure in the second-stage submodel, along with integer decision variables. To efficiently solve the model, a comprehensive set of techniques is applied. This includes employing linearization techniques, converting the second-stage submodel into a single-stage equivalent, transforming an integer variable into multiple binary variables, and utilizing other methods to equivalently reformulate the model into a mixed-integer linear programming problem (MILP). These transformations render the model amenable to solution by the integer L-shaped method. A simplified example clarifies the solution procedures of the model and algorithm, establishing the theoretical foundation for their practical implementation. Subsequently, to empirically demonstrate the practicality of the proposed model and algorithm, a real-world case study is conducted, effectively validating their utility.
Land Use Land Cover Changes and Its Impact on Land Surface Temperature in Rajpur-sonarpur Municipal Area
Authors: Mondal Pompa , Mistri Tapas 
Published: January 2024

Abstract

Rapid urban growth within short period of time creates havoc changes in land use/land cover (LULC) all over the world specially in developing countries. Numerous Indian cities are facing such type of problems mainly due to the unplanned and haphazard urban growth. The present study emphasizes on the LULC changes using satellite imageries from 1991 to 2021 at ten years interval and its impacts on LST (Land Surface Temperature) in Rajpur-Sonarpur Municipal area located in the district of South 24 Parganas, West Bengal. Results shows that positive changes have occurred only in case of built-up area and fallow land while negative changes have found in vegetation coverage, water bodies and agricultural land which were a dominant land cover classes in 1991 accounting 44.04% of the total geographical area. On the time being there is an increasing tendency of construction sites and built-up areas at the cost of vegetation coverage as well as the water bodies and agricultural lands which in turn increase the land surface temperature as a continuous process. So, to arrest the rising temperature and minimize the ill effects of such changes immediate thinking of new urbanism should be adopted and implemented.
Salidroside inhibits platelet-derived growth factor BB-induced human aortic smooth muscle cell phenotype switching via PDGFR-β/AKT/mTOR/HIF-1α pathway 1
Authors: Zhang Yongjie , Yan Zhigang , Lin Fei , Liu Huibing , Zhao Guoan 
Published: January 2024

Abstract
Vascular smooth muscle cell (VSMC) phenotype transformation is the pathological basis of vascular remodeling diseases such as in-stent restenosis after percutaneous coronary intervention. Salidroside has anti-hypoxic and anti-endothelial cell apoptotic effects and inhibits tumor cell proliferation; however, none of the published studies have reported its effect on VSMC phenotype switching to date. In this study, we investigated the effect of salidroside on platelet-derived growth factor BB (PDGF-BB)-induced human aortic smooth muscle cell (HASMC) phenotype switching and explored its pharmacological mechanisms.HASMCs were stimulated with PDGF-BB to establish a cell phenotype switching model and then treated with salidroside. Cell viability was detected using the CCK-8 assay, cell migration was detected by performing the Transwell assay, and F-actin was stained with fluorescently labeled phalloidin. Proliferating cell nuclear antigen, migration-related proteins MMP-9 and fibronectin, phenotype switching markers α-SMA and osteopontin, phosphorylated and non-phosphorylated AKT, mTOR proteins, PTEN, PDGFR-β, and HIF-1α protein were detected through western blotting. Compared with the PDGF-BB indution group, the salidroside treatment group exhibited decreased HASMC proliferation and migration; the expression of the contractile phenotype marker α-SMA increased, and the expression of the secretory phenotype marker osteopontin decreased. Furthermore, phosphorylated AKT, mTOR, PDGFR-β, and HIF-1α protein expression decreased. Salidroside may inhibit phenotype switching of HASMC induced by PDGF-BB through the PDGFR-β/AKT/mTOR/HIF-1α pathway; hence, it may be useful in treating vascular remodeling diseases such as in-stent restenosis after percutaneous coronary intervention.