bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing an initial 3D hydrostratigraphical model of the emerged part of the Pelotas Basin along the northern coast of Rio Grande do Sul state, Brazil
Authors: Marquetto Luciano , Jüstel Alexander , Troian Guilherme Casarotto , Reginato Pedro Antonio Roehe , Simões Jefferson Cardia 
Published: November 2023

Abstract

The coastal plain of Rio Grande do Sul state is highly vulnerable to expected changes in sea level, while having an increasing population and consequently increasing water demands. Adequate management is essential to restrain contamination, depletion and salinization of the region’s aquifers considering current and future challenges, but geologic knowledge is essential to guide groundwater sustainable practices. To contribute to this discussion this work integrated existing geological data from the northern coast of Rio Grande do Sul state to create a three dimensional representation of the main hydrostratigraphical units of the region and its relation to the basement rocks, expanding the current knowledge of the coastal aquifer system. A review of existing data was carried out, consisting of 307 borehole logs from 13 municipalities inside the area of interest, as well as 19 vertical electrical soundings and 37 logs from oil and coal exploratory drillings, that resulted in 315 input points for the model. This work builds up on the conceptual model previously developed for the area, that defined four hydrostratigraphical units for the region, and was able to constrain the geometries of the main aquifers (unit 1 and 3) and aquitards (unit 2 and 4) and their relation to the basement rocks, showing them to be more heterogeneous in thicknesses and extent than previously thought. In addition, this work was able to model what could be a fifth hydrostratigraphical unit, that strongly differs from the other four and could be an indication of the alluvial fans previously described in the literature.
The impact on postoperative complications and analgesia of different nerve block techniques after hypospadias repair: a network meta-analysis
Authors: Feng Lan , Zheng Jiang , Zheng Xiangqi , Ma Yu , Fu Hong 
Published: November 2023

Abstract

Hypospadias is the most common congenital anomaly of the genitourinary system, and hypospadias repair is one of the most common urological surgeries performed. Regional anesthesia utilized for this penile reconstructive surgery is typically either caudal block(CB) or penile nerve block(PB) or pudendal nerve block(PNB), but the evidence regarding whether these techniques will increase postoperative complications is still controversial. Therefore we aimed to assess the association between block type and the incidence of postoperative complications. Relevant studies were identified by searching electronic databases, including randomized controlled trials, case-control, and cohort studies from inception until June 10th, 2023 and performed this network meta-analysis.
A total of 29 studies were included, involving a population of 5284 pediatric patients. Our network meta-analysis revealed that PB may be the optimal nerve block technique to minimize postoperative complications in hypospadias repair surgery. Regarding postoperative analgesic effects, PNB ranked first to reduce consumption of postoperative analgesics, followed by PB. Therefore PB may be one of the most effective techniques to decrease complication rates in hypospadias repair, and significantly reduced reliance on postoperative analgesics of these patients. However, due to clinical and methodology heterogeneity among included studies, further validation is warranted.
Integrative analyses of genes associated with oxidative stress and cellular senescence in triple-negative breast cancer
Authors: Wu Lihua , Zheng Hongyan , Guo Xiaorong , Li Nan , Qin Luyao , Li Xiaoqing , Lou Ge 
Published: November 2023

Abstract

Purpose
This study was intended to construct a prognostic model based on oxidative stress and cellular senescence related difference expression genes (OSCSRDEGs) for TNBC.
Methods
The Cancer Genome Atlas (TCGA) databases and two Gene Expression Omnibus (GEO) databases were used to identify OSCSRDEGs. The relationship between OSCSRDEGs and immune infiltration was examined using single-sample gene-set enrichment analysis (ssGSEA), ESTIMATE, and the CIBERSORT algorithm. Least absolute shrinkage and selection operator (LASSO) regression analyses, Cox regression and Kaplan-Meier analysis were employed to construct a prognostic model. Receiver operating characteristic (ROC) curves, nomograms, and decision curve analysis (DCA) were used to evaluate the prognostic efficacy. Gene Set Enrichment Analysis (GSEA) Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) were utilized to explore the potential functions and mechanism.
Results
A comprehensive analysis identified a total of 27 OSCSRDEGs, out of which 15 genes selected for development of a prognostic model. A high degree of statistical significance was observed for the riskscores derived from this model to accurately predict TNBC Overall survival. The decision curve analysis (DCA) and ROC curve analysis further confirmed the superior accuracy of the OSCSRDEGs prognostic model in predicting efficacy. Notably, the nomogram analysis highlighted that DMD exhibited the highest utility within the model. In comparison between high and low OSCScore groups, the infiltration abundance of immune cells was statistically different in the TCGA-TNBC dataset.
Conclusion
Our study identified four essential OSCSRDEGs (CFI, DMD, NDRG2, and NRP1) and precisely constructed an OSCS-related prognostic model for patients with TNBC.
Remittances and Household-level Gender Disparity in Education Attainment: Evidence from Pakistan
Authors: Sohail Zahra , Khan Muhammad Omer , Tahir Rabiya , Ahmad Imtiaz 
Published: November 2023

Abstract
This paper focuses on a key gender norm prevalent in many developing economies, particularly in South Asian economies, whereby the education of males is preferred over females within a household—giving rise to disparities in education attainment. Specifically, we investigate the impact of remittances on gender disparity in educational attainment. We construct household-level measures of gender disparity in mean years of schooling and out-of-school children using the Pakistan Social and Living Standard Measurement Survey (PSLM) 2019–2020. Using propensity score matching methods we construct counterfactuals that help in estimating the causal impact of remittances on gender disparity in educational attainment. Our results indicate that gender disparity against women both in terms of mean years of schooling and out-of-school children declines in households that receive remittances. Moreover, the disparity-reducing impact of remittances is robust to different specifications of propensity score matching methods. The endogenous treatment effects model also shows that the remittances reduce household level gender disparity in education, although the impact is more pronounced in urban areas compared to rural areas. These results suggests that remittances are one of the key channels that result in the transformational change in gender norms related to education.
Subject classification codes: J16, F24, I24, R23
Laser treatment for scars after cleft lip surgery: A systematic review and meta-analysis
Authors: Pang Xuefei , Chi Haoshu , Zhan Zongli , Yu Zuyin , Cai Ming 
Published: November 2023

Abstract

Background
Current studies are controversial on the optimal treatment of postoperative scar treatment by cleft lip. Our objective is to elucidate the therapeutic effect of laser on postoperative cleft lip scar treatment.
Methods
A systematic review was performed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We searched five electronic databases (EMBASE, PubMed, Web of Science, Cochrane Library and CNKI, from their inceptions until August 8, 2023) and independently assessed the methodological quality and bias risk of the included studies by two investigators using the Cochrane Handbook for Systematic Reviews. Quality assessment of the certainty of evidence was performed based on the Grading of Recommendations Assessment, Development, and Evaluation guidelines. Weighted mean difference of Vancouver Scar Scale were calculated to conduct meta-analysis by Stata statistical software version 14. We also estimated the pool sensitivity as well as testing the possibility of publication bias.
Results
Five studies were included in this meta-analysis involving 255 subjects. Meta-analysis showed that compared with the control group, laser was more effective in treating post-cleft lip scars (WMD = 4.39, 95%CI = 0.54–8.23; Five studies with 255 participants; Low evidentiary certainty, I2 = 99.4%).
Conclusions
Patients treated with laser therapy for postoperative cleft lip scar treatment tend to have lower Vancouver Scar Scale scores, indicating a significant therapeutic effect. However, our results should be interpreted with caution due to the limitations.
Trial registration
identifier CRD42023397042 (18/02/2023) [https://www.crd.york.ac.uk/prospero/].
Prompt Enhance API Recommendation: Visualize the User’s Real Intention behind this Query
Authors: Wang Yong , Chen Linjun , Gao Cuiyun , Fang Yingtao , Li Yong 
Published: November 2023

Abstract
Developers frequently rely on APIs in their daily programming tasks, as APIs have become an indispensable tool for program development. However, with a vast number of open-source libraries available, selecting the appropriate API quickly can be a common challenge for programmers. Previous research on API recommendation primarily focused on designing better approaches to interpret user input. However, in practical applications, it is often difficult for users, especially novice programmers, to express their real intentions due to the limitations of language expression and programming capabilities.To address this issue, this paper introduces PTAPI, an approach that visualizes the user's real intentions based on their query to enhance recommendation performance. Firstly, PTAPI identifies the prompt template from Stack Overflow (SO) posts based on the user's input. Secondly, the obtained prompt template is combined with the user's input to generate a new question. Finally, the newly generated question leverages dual information sources from SO posts and API official documentation to provide recommendations.To evaluate the effectiveness of PTAPI, we conducted experiments at both the class-level and method-level. The experimental results demonstrate the effectiveness of the proposed approach, with a significant improvement in the success rate.
Retinal Nerve Fiber layer Thickness and Radial Peripapillary Capillaries Density in Myopic Adults with Optical Coherence Tomography Angiography
Authors: Ma Chunhui , Chen Chunwen , Zhang Yutong , Yao Jingyan 
Published: November 2023

Abstract

Purpose
To evaluate retinal nerve fiber layer thickness (RNFLT) and radial peripapillary capillaries (RPC) density in adults with different degrees of myopia using optical coherence tomography angiography (OCTA) and explore their relationship with ocular factors, such as axial length (AL) and disc area.
Methods
A total of 188 subjects were included in this cross-sectional study. The eyes were divided into four groups according to AL. OCTA was used for the assessment of RNFLT, RPC density, and other optic disc measurements, such as disc area. One-way analysis of variance was performed to compare differences between four groups, and P value < 0.01 was considered significant.
Results
The RNFLT was significantly thinner in high myopia (HM) group at inferior nasal (IN) quadrant (P = 0.004) than low myopia (LM) group, but thicker at temporal inferior (TI) quadrant (P = 0.006). The RPC density of nasal superior (NS) quadrant, nasal inferior (NI) quadrant, and inferior nasal (IN) quadrant significantly decreased as AL increasing. By simple linear regression analysis, the inside disc RPC (iRPC) density tended to be correlated significantly with AL (0.3997%/mm, P < 0.0001). Peripapillary RPC (pRPC) density was in significant correlation with AL (-0.2791%/mm, P = 0.0045), and peripapillary RNFLT (pRNFLT) was in significant correlation with disc area (0.2774%/mm2, P = 0.0001).
Conclusion
RNFLT and RPC density were closely associated with AL and disc area. They might be new indexes in assessing and detecting myopia development via OCTA.
Comparison of Manual, Automatic, and Voice Control in Wheelchair NavigationSimulation in Virtual Environments: Performance Evaluation of User and MotionSickness.
Authors: Pedroza-Santiago Enrique A. , Quiroz-Ibarra J. Emilio , Bojorges-Valdez Erik R. , Padilla-Castañeda Miguel A. 
Published: November 2023

Abstract
Mobility is a fundamental necessity for individuals with physical disabilities, and wheelchairs play a vital role in improving their quality of life. In recent decades, there has been a growing interest in designing and developing more advanced wheelchairs, particularly regarding control systems that enable users to interact effectively and efficiently with their chairs. Implementing different control systems in wheelchairs has been the subject of research and development to enhance user experience and overcome limitations associated with conventional controls. Virtual reality (VR) is a valuable tool for testing new technologies, ensuring user safety, and reducing development time. This article aims to present a comparative evaluation of various controls implemented in a simulated wheelchair, analyzing their effectiveness and ease of use through navigation in three different daily-life scenarios. Twenty participants(11 males and 9 females) received VR operation and controls training. Each participant completed three tests per control in each scenario. The results showed that participants performed better while navigating with autonomous and manual controls than with voice controls. However, participants experienced associated motion sickness during the interaction. Contrary to voice control, despite causing less motion sickness, the participants' performance shows that a high voice command recognition rate and reliability are mandatory to be a viable option. Our setup represents a useful experimental setup for future research and improvements in developing wheelchair control systems in virtual environments to cater to the individual needs and abilities of end-users in reality.
The Association of Implemented Care Team Configuration Models with Length of Stay and Charges in Hospitalized Patients with Congestive Heart Failure: A Retrospective Analysis of EHR Data
Authors: Williams Tremaine B. , Crump Alisha , Parker Pearman , Garza Maryam Y. , Seker Emel , Swindle Taren , Robins Taiquitha , Sexton Kevin Wayne 
Published: November 2023

Abstract
Background: Clinicians are the conduits of high-quality care delivery. Clinicians have driven advancements in pharmacotherapeutics, devices, and related interventions and improved morbidity and mortality in patients with congestive heart failure over the past decade. Yet, the management of congestive heart failure has become extraordinarily complex and has fueled recommendations from the American Heart Association and the American College of Cardiology to optimize the composition of the care team to reduce the health, economic, and health system burden of high length of stay and hospital charges. Therefore, the purpose of this study was to identify the extent to which care team configuration models of non-specialty clinicians were associated with high length of stay and high charges during the hospitalizations of patients with congestive heart failure.
Methods: This study performed a retrospective analysis of EHR-extracted data on 3,099 patients and their encounters from the Arkansas Clinical Data Repository. The data was analyzed using binomial logistic regression in which adjusted odds ratios reflected the association of specific care team configuration models (i.e., combination of clinical roles) with length of stay and hospital charges.
Results: Care team configuration models that included physicians, residents, and advanced nurse practitioners were generally associated with greater odds of a patient having a high length of stay or a high charge hospital encounter. Registered nurses were the only specific care team role found within all care team configuration models and has consistently been associated with decreased length of stay and decreased charges. Additionally, the study validated the Van Walraven Elixhauser Comorbidity Score by finding that its quartiles were statistically significantly associated with length of stay and charges.
Conclusions: Cardiologists, alone, cannot shoulder the burden of caring for hospitalized patients with congestive heart failure. Care team configuration data within electronic health record systems of hospitals could be an effective method of isolating and tracking high risk patients. Within multidisciplinary care teams, registered nurses may be particularly effective in advancing real-time risk stratification by applying the Van Walraven Elixhauser Comorbidity Score at the point-of-care.
Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial
Authors: Flygt Hjalmar , Söderlund Stina , Richter Johan , Saussele Susanne , Koskenvesa Perttu , Stenke Leif , Mustjoki Satu , Dimitrijevic Andreja , Stentoft Jesper , Majeed Waleed , Roy Lydia , Wolf Dominik , Dreimane Arta , Gjertsen Bjorn , Gedde-Dahl Tobias , Ahlstrand Erik , Markevärn Berit , Hjorth-Hansen Henrik , Janssen Jeroen , Olsson-Strömberg Ulla 
Published: November 2023

Abstract
Tyrosine kinase inhibitor (TKI) discontinuation in chronic myeloid leukemia (CML) has become part of routine care for patients with a sustained deep molecular response (DMR). Approximately 50% experience a molecular relapse upon TKI cessation. Most of them quickly regain DMR upon TKI resumption. Whether these patients can achieve a second treatment-free remission (TFR) remains unclear. DAstop2 (ClinicalTrials.gov ID: NCT03573596) is a prospective study including patients with a failed first TFR attempt re-treated with any TKI for ≥ one year. Upon entering the study, patients received the TKI dasatinib for additional two years. Patients with sustained DMR for ≥1 year qualified for a second TKI stop. Ninety-four patients were included between Oct 2017-Dec 2021. At the time of data analysis, 62 patients had attempted a 2nd stop. After a median follow-up of 27 months from 2nd stop, TFR rates were 61%, 56% and 46% at 6, 12 and 24 months respectively. No progression to advanced stage disease was seen and 87% had re-achieved MR4 within a median of 3 months from TKI re-initiation. In summary, we show that a 2nd TFR attempt after dasatinib treatment is safe, feasible and TFR rates seem in the range of those reported in trials of a first TKI stop.
Influence of roughness height on the distribution of modeled turbulence statistics in non-aerated skimming flows in steep stepped spillways
Authors: Toro Juan Pablo , Blanc Alex , Moreno-Casas Patricio , Sepúlveda Sebastián 
Published: November 2023

Abstract

The stepped spillway design is widely used globally for its energy dissipation capabilities through its stepped design and air entrainment capacity, crucial for safe hydraulic structure operation. The most common condition found in stepped spillways is the skimming flow regime. This study numerically investigated the influence of the roughness height (KS) on the distribution of mean flow variables and modeled turbulence statistics in the non-aerated portion of a steep stepped spillway with a constant angle of 51.34°. Three roughness heights of 6.26, 3.13 and 1.57 cm were considered corresponding to a relation step height/horizontal length of 10/8, 5/4 and 2.5/2 (cm/cm), respectively. The results show that profiles of modeled turbulent kinetic energy (TKE) at different step edges can be collapsed into one single curve for relative roughness (Ks/h) smaller than 0.8. For larger ratios of roughness height to water depth, this behavior is not observed and for a given distance away from the wall, values of TKE show a broad range of values, with increasing values as boundary layer grows. A similar trend was obtained for the distribution of TKE along a water column that includes the cavity. The existence of an upper limit for the ratio between the roughness height and the water depth can now be incorporated in the hydraulic design of new steep stepped spillways.
A multiplexed microfluidic continuous-flow electroporation system for efficient cell transfection
Authors: VanderBurgh Jacob A. , Corso Grant T. , Levy Stephen L. , Craighead Harold G. 
Published: November 2023

Abstract
Cellular therapies have the potential to advance treatment for a broad array of diseases but rely on viruses for genetic reprogramming. The time and cost required to produce viruses has created a bottleneck that constricts development of and access to cellular therapies. Electroporation is a non-viral approach for genetic reprogramming that bypasses these bottlenecks, but current electroporation technology suffers from low throughput, tedious optimization, and difficulty scaling to large-scale cell manufacturing. Here, we present an adaptable microfluidic electroporation platform with the capability for rapid, multiplexed optimization with 96-well plates. Once parameters are optimized using small volumes of cells, transfection can be seamlessly scaled to high-volume cell manufacturing without re-optimization. We demonstrate optimizing transfection of plasmid DNA to Jurkat cells, screening hundreds of different electrical waveforms of varying shapes at a speed of ~3 s per waveform using ~ 20 µL of cells per waveform. We selected an optimal set of transfection parameters using a low-volume flow cell. These parameters were then used in a separate high-volume flow cell where we obtained similar transfection performance by design. This demonstrates an economical method for scaling to the volume required for producing a cell therapy without sacrificing performance.