bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothyroidism impairs the circadian rhythmicity of clock genes and proteins involved in gut nutrient absorption in female mice
Authors: Secio-Silva Ayla , Evangelista-Silva Paulo Henrique , Emrich Felipe , Selvatici-Tolentino Letícia , Ferreira Maíza , Silva Ana Bárbara de Paula , Gomes Bruno Henrique , Figueira-Costa Tatienne Neder , Oliveira André Gustavo , Peliciari-Garcia Rodrigo Antonio , Goulart-Silva Francemilson , Bargi-Souza Paula 
Published: February 2025

Hypothyroidism is a common thyroid dysfunction with a higher prevalence in women. Impairments in the regulation of basal metabolism, small intestine nutrient transporter, dyslipidemia, and disruption in circadian clocks have been associated with the thyroid disorder. This study aimed to evaluate whether hypothyroidism affects the small intestine circadian clock and the daily expression pattern of gut nutrient transporters in female mice. Adult female C57BL/6J mice were subjected to hypothyroidism by the administration of methimazole (0.1%) and sodium perchlorate (1%) in drinking water for 45 days. After, the animals were subdivided and euthanized every 4 h over the 24 h period under deep anesthesia. The proximal small intestine segment was collected and immediately frozen for gene expression analysis of circadian core clock components (Bmal1, Per2, Cry1, and Nr1d1) and nutrient transporters by RT-qPCR. The daily protein content of nutrient transporters involved in the absorption of the products of hydrolysis of lipids, proteins, and carbohydrates was evaluated over 24 h in isolated small intestinal epithelium by Western blotting. The expression of clock genes and protein content of nutrients transporters in the jejunum of control female mice exhibited a well-defined circadian rhythmicity, while no rhythmic oscillation over 24 h was observed for the transporter transcripts. Hypothyroidism abolished the circadian rhythmicity of circadian clock, punctually reduced the transcript content of Slc2a5 (GLUT5) at ZT12 and Slc2a2 (GLUT2) at ZT4, and disrupted the circadian oscillation of L-FABP, CD36, PEPT1, and GLUT2 protein contents in the small intestine of female mice. In conclusion, our findings indicate that thyroid hormones modulate the circadian clock of small intestine and the daily rhythmicity of components related to absorptive processes in female mice. Moreover, our data suggest that the mechanisms triggered by thyroid hormones involve posttranscriptional and/or translational modifications of proteins related to lipid, protein, and carbohydrate absorption. Together, these data contribute to the general comprehension of metabolic alterations often observed in hypothyroidism and have far-reaching implications at clinical levels considering the higher worldwide prevalence of hypothyroidism in women and its association with obesity and metabolic syndrome.
Uso de lâminas de cera associado ao cianoacrilato na reconstrução parcial de carapaça de jabuti-piranga (Chelonoidis carbonaria) vítima de queimaduras - relato de caso
Authors: Batista Mariana de Andrade , Santos João Victor Batista dos , Silva Juliana Costa da , Alves Sayonara Freitas de Carvalho , Oliveira Milena Rayane Dantas , Melo Maria Eduarda Storti de , Santos Ellen Clara Gomes dos , Pereira Ana Carolina Trompieri Silveira , Santos Patrícia Oliveira Meira dos , Lima Victor Fernando Santana 
Published: February 2025

O Jabuti-piranga (Chelonoidis carbonária), pertencente à ordem Chelonia e à subordem Cryptodira, é um réptil caracterizado por possuir a coluna vertebral acoplada à carapaça. A espécie se distingue das demais por possuir uma coloração avermelhada nas extremidades distais de seus membros e apresentam as escamas pré-frontais repartidas e pequenas. Esse trabalho tem como objetivo relatar o uso de lâminas de hidrocarbonetos associado a cianoacrilato na reconstrução parcial de carapaça de jabuti-piranga (C. carbonaria) vítima traumatismo por queimaduras. Foi atendido na clínica veterinária escola uma Jabuti-Piranga (C. carbonaria) fêmea, adulta, pesando 2,5 kg, apresentando perda parcialmente sua carapaça, vítima de um trauma de casco causado por um ligado a um incêndio doméstico. Como tratamento, foi realizada a limpeza da ferida com Clorexida e extrato de Aloe vera, administração de Enrofloxacino e Meloxicam e aplicação de lâminas de cera associado a resina de cianoacrilato para a reconstrução de seu casco. Portanto, o emprego das lãminas de hidrocarboneto associado a cianocrilato são eficazes para a reconstrução de carapaça e das partes ósseas e córneas perdidas, possibilitando proteção aos órgãos internos e ao exoesqueleto dos testudines.
Pengaruh Pembelajaran Analogi Melalui Selective Problem Solving (SPS) terhadap Hasil Belajar Pengukuran Luas di Sekolah Dasar
Authors: Rosyida Nelly Kholifatur , Amir Mohammad Faizal , Wardana Mahardika Darmawan Kusuma 
Published: February 2025

Penelitian ini bertujuan untuk mengidentifikasi pengaruh pembelajaran analogi melalui Selective Problem Solving (SPS) terhadap hasil belajar pada materi pengkuran luas. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksperimen dan menggunakan desain one-shot case study. Subjek penelitian adalah kelas V Sekolah Dasar sebanyak 25 siswa. Pemilihan subjek penelitian menggunakan teknik sampling jenuh. Teknik pengumpulan data menggunakan tes. Analisis data terdiri dari data statistik deskriptif, validitas, realibilitas, pengujian normalitas, uji-t. Instrumen penelitian adalah tes yang terdiri dari masalah sumber dan masalah target. Hasil pembelajaran analogi melalui SPS diperoleh yaitu 0,90 < 0,05, yang menunjukkan bawah pembelajaran SPS berbasis analogi memiliki dampak pada kemampuan berpikir siswa. Pengaruh dari hasil belajar siswa dalam pembelajaran analogi ini siswa mampu berfikir lebih kreatif dan memudahkan siswa untuk menemukan konsep yang akan meyelesaikan masalah. Hasil penelitian ini menyarankan agar siswa mampu berpikir secara analogi melalui model SPS pada materi pengukuran luas, sehingga dapat meminimalisir kesalahan konsep pada pengetahuan awal dan dapat mengidentifikasi konsep maupun proses penyelesaian pada masalah sumber untuk membantu menyelesaikan masalah target dengan tepat.
Fenomena Campur Kode dalam Penggunaan Bahasa Melayu Jambi di Pasar Baru Kota Bangko
Authors: Nisa Afrillia , Akhyaruddin Akhyaruddin , Priyanto Priyanto , Andiopenta Andiopenta 
Published: February 2025

Latar belakang penelitian ini adalah ditemukannya fenomena penggunan campur kode bahasa Melayu Jambi yang dijumpai di pasar Baru Bangko. Tujuan dari penelitian ini berupa mengetahui bentuk, fungsi, dan bahasa etnis penyumbang campur kode dalam bahasa Melayu Jambi yang dijumpai di pasar Baru Bangko. Data penelitian berupa percakapan lisan pembeli ataupun penjual yang mengandung campur kode bahasa Melayu Jambi di Pasar Baru Bangko. Data diperoleh dengan teknis observasi, simak, rekam, catat, dan wawancara. Penelitian ini menggunakan pendekatan kualitatif dengan teknik analisis isi. Ada tiga tahapan yang dilalui dalam proses analisis berupa mereduksi data, menyajian data, dan menarik kesimpulan. Uji keabsahan data dilakukan dengan teknik triangulasi metode dan teori. Hasil penelitian menemukan bentuk campur kode pada tataran kata sebanyak 30 data dan frasa sebanyak 4 data. Fungsi terjadinya campur kode yang ditemukan di pasar Baru Bangko meliputi fungsi menghormati lawan bicara, fungsi menanyakan sesuatu, dan fungsi menegaskan pembicaraan. Bahasa penyumbang campur kode bahasa Melayu Jambi meliputi bahasa Minangkabau sebanyak 20 data, bahasa Jawa sebanyak 11 data, dan bahasa Batak sebanyak 3 data.
المخططات العاطفية لدى طلبة المرحلة الاعدادية
Authors: Al-wani Abeer Abdullah Hussein Ali , Al-Dulaimi Safi Ammal Salih 
Published: February 2025

الأهداف: تسعى الدراسة التعرف إلى المخططات العاطفية لدى طلبة المرحلة الإعدادية، والتعرف أيضا إلى الفروق في المخططات العاطفية لدى طلبة المرحلة الإعدادية على وفق متغير الجنس (ذكور– إناث) والتخصص (علمي– أدبي) وعلى وفق الوالدين (وجود الوالدين- فقدان أحدهما - فقدان كلاهما).
المنهجية: طبقت الدراسة على العينة بصورة العشوائية بسيطة بلغ حجمها(539)طالبا وطالبة من مدارس قسم تربية قضاء الفلوجة التابعة لمديرية تربية الأنبار بواقع (357) طالباً وطالبة من التخصص العلمي و(182) من التخصص أدبي، أما الجنس بلغ عدد ذكور(222) والإناث (317) .وبتبني الباحثان مقياس المخططات العاطفية الذي أعده(روبرت ليهي2002)وفقاً لنظريته وترجما الأداة وكيفتها على البيئة العراقية عينة الدراسة، يتكون المقياس من(50)فقرة توزعت على 14 مجالاً، وكانت البدائل(تنطبق عليَّ بدرجة كبيرة، تنطبق عليَّ بدرجة متوسطة، تنطبق عليَّ بدرجة قليلة،لا تنطبق عليَّ مطلقاً).
النتائج: أظهرت نتائج الدراسة أن العينة سجلت درجة منخفضة في المخططات العاطفية، وتبين أنه ذي دلالة معنوية عند مستوى(0.05)وبدرجة حرية(538) ولصالح المتوسط الفرضي ولا يوجد فرق ذات دلالة إحصائية في مستوى المخططات العاطفية لدى الطلبة الذكور والإناث والتخصص العلمي والأدبي، ووجود الوالدين أو فقدان أحدهما أو كلاهما.
الخلاصه: إن للمخططات العاطفية تأثير على العلاقة بين الأفراد وتنظيم وظيفتهم ومضمونهم، مما يؤثر على الفرد وفق التفسير الخاطئ الذي يحمله الفرد عن نفسه وعن العالم المحيط الذي يعيش فيه، وفي نفس الوقت فينتج عنه حالة عاطفية تتناسب مع ما هو عليه، سواء كان حباً، أو حزناً، أو غضباً...إلخ. وتوصي الدراسة بإجراء دراسات تبحث في العلاقة بين المخططات الانفعالية والتنشئة الاجتماعية لدى عينة مختلفة والمتغيرات الأخرى كأنماط الشخصية، والعوامل النفسية والاجتماعية لعينة من طلاب الجامعة.
Międzynarodowy przepływ wiedzy i technologii
Authors: Kuźnar Andżelika 
Published: February 2025

DEFINICJA POJĘCIA: Wiedza to zbiór przetworzonych informacji, który służy do podejmowania racjonalnych decyzji lub – szerzej – jest to dobro niematerialne. Technologia obejmuje przedmioty fizyczne oraz wiedzę techniczną i menedżerską pozwalającą wytwarzać, rozwijać i doskonalić produkty działalności gospodarczej. Przenoszenie wiedzy lub technologii między podmiotami zlokalizowanymi w różnych krajach oznacza międzynarodowy transfer wiedzy lub technologii.
ANALIZA HISTORYCZNA POJĘCIA: Metody transferu wiedzy kształtowały się w kontekście postępu cywilizacyjnego. W XX i XXI wieku rozwój technologii dał początek erze gospodarek opartych na wiedzy, umożliwiając globalny i szybki przepływ wiedzy.
UJĘCIE PROBLEMOWE POJĘCIA: Wyróżnia się handlowe (handel dobrami, usługami, prawami własności intelektualnej) i pozahandlowe (BIZ, współpraca B+R, przepływy personelu) kanały międzynarodowego transferu wiedzy i technologii.
REFLEKSJA SYSTEMATYCZNA Z WNIOSKAMI I REKOMENDACJAMI: Kanały przekazywania wiedzy są wzajemnie powiązane i przenikają się. Pomimo relatywnie dużej łatwości dostępu do informacji wybór właściwego kanału transferu jest trudny, a decyzja powinna być oparta na analizie różnych czynników.
Ucieleśnione poznanie
Authors: Bielas Jacek 
Published: February 2025

DEFINICJA POJĘCIA: Pojęcie ucieleśnionego poznania dotyczy istotnego znaczenia różnych aspektów całokształtu ciała, nie tylko układu nerwowego, w ścisłym związku ze środowiskiem jako konstytutywnego elementu systemu poznawczego.
ANALIZA HISTORYCZNA POJĘCIA: Geneza współczesnych badań nad ucieleśnieniem poznania wiąże się głównie z krytyką klasycznego ujęcia procesów poznawczych w kategoriach komputacjonizmu, według którego procesy te dzieją się zasadniczo w mózgu i polegają na obliczeniowym przetwarzaniu informacji w formie symbolicznych reprezentacji przedmiotu poznania. W toku tej krytyki pojęcie ucieleśnionego poznania stało się wiodącą ideą interdyscyplinarnego projektu badawczego określanego mianem ucieleśnionej kognitywistyki.
UJĘCIE PROBLEMOWE POJĘCIA: Pojęcie ucieleśnionego poznania, pomimo swego naukowego statusu, jawi się jako wieloznaczne, a projekt ucieleśnionej kognitywistyki jako mało spójny. Przede wszystkim jednak kwestia faktycznej roli cielesności w aktywności poznawczej również pozostaje nierozstrzygnięta w ramach spektrum stanowisk od różnych wersji komputacjonizmu, na jednym biegunie, poprzez „minimalne”, aż po „ekstremalne” ucieleśnienie poznania – na biegunie przeciwstawnym.
REFLEKSJA SYSTEMATYCZNA Z WNIOSKAMI I REKOMENDACJAMI: Współczesna problematyka ucieleśnionego poznania obejmuje szereg podejść do tej kwestii, które można różnie klasyfikować. Ta różnorodność przedmiotowa i metodologiczna wiąże się z wieloma trudnościami, na przykład w zakresie replikacji badań. Jednocześnie natomiast rozwój projektu ucieleśnionej kognitywistyki wydaje się sprzyjać zarówno poszerzeniu zakresu zagadnień, jak i właśnie zachowaniu spójności tych zagadnień, które podejmowane są w dziedzinie podejmowanych w dziedzinie nauk o poznaniu, co wymaga jednak dalszych wysiłków o charakterze teoretycznym oraz empirycznym.
Analisis Laporan Keuangan Perusahaan Sebagai Penilaian Kinerja Perusahaan (Studi Pustaka pada Perusahaan BUMN Sektor Konstruksi yang Terdaftar di Bursa Efek Indonesia 2020-2022)
Authors: Jumiyati  , Revita Maria Lapriska Dian Ela , Sugiarti  , Oktiyani Rina 
Published: February 2025

The development of the business world in an increasingly open economic situation needs to be based on performance assessment facilities and systems that can encourage companies towards increasing efficiency and competitiveness which will strengthen capital and have an impact on the company's performance assessment. So that it is able and survives in the increasingly tight business competition today. Companies can analyze financial reports, especially in conducting performance assessments. In the research conducted by the author using descriptive qualitative methods and Literature Studies on the financial reports of 4 state-owned construction sector companies listed on the Stock Exchange: PT Wijaya Karya (Persero) TBK, PT Waskita Karya (Persero) Tbk, PT Adhi Karya Tbk (ADHI), and PT Pembangunan Perumahan (Persero) Tbk. The purpose of this research is to calculate and analyze the Liquidity, Solvency and Profitability of Financial Reports as an assessment of the Company's Performance. The results of the study show that the Liquidity Ratio (current ratio) of PT Waskita Karya (Persero) Tbk has a consistently high current ratio for three consecutive years, with the highest figure in 2020 at 168.89%. This shows the company's ability to meet its short-term obligations better than other companies such as PT Wijaya Karya (Persero) Tbk and PT Adhi Karya (Persero) Tbk which have lower ratios. The solvency ratio of PT Waskita Karya (Persero) Tbk also stands out with a very high debt to equity ratio, reaching 979.55% in 2022. This indicates that the company is highly dependent on debt in its funding structure. High dependence on debt can increase financial risk, Profitability Ratio, PT Wijaya Karya (Persero) TBK and PT Waskita Karya (Persero) Tbk showed an increase in Net Profit Margin, which indicates an improvement in operational efficiency and management. On the other hand, PT Adhi Karya (Persero) Tbk and PT Pembangunan Perumahan (Persero) Tbk experienced a decline in margin, although they maintained a positive margin. Different receivable turnover ratios also provide an overview of the efficiency of receivables management in these companies. PT Wijaya Karya (Persero) Tbk for example, in 2021 had a very high receivables turnover ratio of 790.28%, indicating that this company is able to manage receivables very efficiently, accelerating cash collection from credit sales.
Cash management practices and financial performance of livestock marketing cooperative societies in Marsabit County, Kenya
Authors: Hido Dae , Koori Jeremiah 
Published: February 2025

An objective evaluation of the performance of livestock cooperative societies is imperative in order to ascertain whether they fully reward members for the use of their equity fund. The evaluation of agricultural cooperatives using the conventional measures of financial performance like return on asset, return on equity, return on operating equity net margins on sales etc do no yield unequivocal results. Livestock marketing cooperatives societies in Marsabit County have continuously used these conventional measures giving mixed results but failing to indicate whether they create value for member producers. The objective of this study therefore sought to establish the effect of cash management practices on the performance of livestock marketing cooperative societies in Marsabit County. The key theories anchoring the study are; Keynesian theory of money, free cash flow theory and stakeholder theory. The current study adopted quantitative research design. The target population was twelve livestock marketing cooperative societies in Marsabit County that have been operational in the period 2019-2023. The unit of observation was the 110 employees in the finance departments. The study used stratified random sampling technique to arrive at a sample size of 86.. The study utilized both primary and secondary data where primary data was obtained from questionnaires that was presented to respondents and secondary data collection tool was used to obtain secondary data from audited financial reports accessible from society’s offices and ministry of cooperatives and micro-small and medium enterprises development. Diagnostic tests including multicollinearity test, normality test and reliability were conducted to confirm the model fitness. Data was analyzed using descriptive and regression analysis. The regression results showed that periodic cash plan (p=0.003, <0.05), investing of surplus cash (p=0.19, <0.05), managing cash flows (p=0.00, <0.05) had positive statistically significant effect on financial performance. Bank credit line had positive effect on financial performance even though the change was not significant. The study therefore recommends that managers of Marsabit county livestock marketing cooperative societies should enhance effective use and preparation of cash budgets and consistent investment of surplus cash. Further, there should be more decentralization of receipts and application of accounting packages. For policy, the study recommends that policy makers and regulators should concentrate on creating regulations that will allow marketing societies to thrive through provision of appropriate infrastructure for wider market.
REPRESENTASI TOXIC MASCULINITY & BULLYING PADA IKLAN LAYANAN MASYARAKAT KEMENDIKBUD RI “INI GAK LUCU”
Authors: Krisna Anjasmani Rury , Widyananda Putra Ricky 
Published: February 2025

Pada tahun 2023, Toxic masculinity dan bullying menjadi perbincangan hangat di kalangan masyarakat Indonesia maupun mancanegara. Banyak hal yang mempengaruhi toxic masculinity dan bullying dari cara berpakaian, gaya berbicara, aksesoris merupakan salah satu bentuk komunikasi. Melalui pakaian, seseorang dapat menyampaikan pesan kepada orang lain. Pesan tersebut digunakan untuk pencitraan atau bentuk branding seseorang itu sendiri. Berdasarkan hal tersebut, penulis tertarik untuk mengkaji bagaimana representasi visual yang disampaikan dalam iklan layanan masyarakat (ILM) yang berjudul “Ini Gak Lucu” mengenai toxic masculinity dan bullying. Penelitian ini menggunakan analisis semiotika Charles Sanders Peirce untuk menerjemahkan makna simbol-simbol dalam iklan layanan masyarakat (ILM). Dalam semiotika Peirce dibagi menjadi tiga elemen utama yakni tanda, objek, dan interpretan. Metode yang digunakan adalah kualitatif. Bertujuan untuk menjelaskan fenomena secara mendalam, melalui pengumpulan data yang mendalam. Hasil yang dapat diambil dari penelitian ini adalah pesan moral yang di sampaikan melalui visual iklan layanan masyarakat yang berjudul “Ini Gak Lucu” dapat membuka mata kita untuk lebih menghargai satu sama lain tanpa memandang gender.
PENGELOLAAN SAMPAH RUMAH TANGGA DI WILAYAH KERJA PUSKESMAS
Authors: Amalia Riski , Sari Murni Nani , Arie wahyudi  , Yusnilasari  
Published: February 2025

Background: Everyone produces waste every day. Various human activities, both directly and indirectly, produce waste. The more sophisticated technology in the world, the more waste will be generated. Environmental cleanliness, including the presence of rubbish, has a big impact on everyone's health. Based on a field survey conducted by the author in the Celikah Community Health Center working area, OKI Regency, the absence of a Temporary Waste Disposal Site (TPSS) is the main cause of community behavior in managing household waste. Method: This type of quantitative research uses descriptive analytical techniques with a cross-sectional design. The research was carried out in the working area of the Celikah Community Health Center, Ogan Komering Ilir Regency in February-April 2024. The population in this study were all heads of families (KK) in the working area of the Celikah District Health Center. OKI with a total sample of 99 people taken using Purposive Sampling Technique. Data analysis was carried out univariately, bivariately using the Chi-Square Test. Results: The research results showed that knowledge had a value of p = 0.000, attitude p = 0.000, education p = 0.000, social economy p = 0.000 and availability of facilities p = 0.000 Conclusion: There is a relationship between knowledge, attitudes, education, socio-economic level and availability of facilities and household waste management in the Puskesmas work area.
Keywords: Management, Waste, Household, Community Health Center
Analisis Implementasi Open Member Universal Health Coverage (UHC) 100% di Dinas Kesehatan Kabupaten Musi Rawas Utara Tahun 2024.
Authors: Defriansyah Dedi , Wahyudi Arie , Harokan Ali , Eka Anggreny Dian 
Published: February 2025

Background: The goal of Universal Health Coverage (UHC) is good and affordable health services for everyone. (Pradana, 2022). This study aims to analyze the relationship between the registration implementation mechanism, knowledge, attitudes, abilities, leadership, infrastructure, compensation, workload in North Musi Rawas Regency in 2024. Method: This type of research is a quantitative analytical survey with a cross-sectional approach. The sampling technique used is the sampling method or sampling technique. The sample in this study was the entire total population (Total Sampling) used as a research sample totaling 35 registration officers at the Health Office, Hospitals, Health Centers, and BPJS Kesehatan. The study was conducted in March-April 2024. Data collection was carried out using a questionnaire. Data were analyzed using Univariate and Bivariate. Result : Based on the results of the study variable Knowledge (p Value 0.000), Attitude (p Value 0.003), Ability (p Value 0.256), Leadership (p Value 0.365), Facilities and infrastructure (p Value 1.000), Compensation (p Value 1.000), Workload (p Value 0.677), in the Implementation of Universal Health Coverage (UHC) registration in North Musi Rawas Regency. Conclusion : There are relationship between knowledge, attitude, abilities, leadership, infrastucture, compensation, workload in the implementation of UHC registration.

Keywords: Universal Health Coverage (UHC), Registration, Knowledge, Attitude