bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genuine or impression management? Uncovering biases in how people respond to the Black Lives Matter movement in sport
Authors: Park Youngho , Kwak Dae Hee 
Published: December 2023

PurposeNational surveys reveal that sports fans exhibit greater support for athletes, sports teams and leagues endorsing social justice initiatives compared to the general population, highlighting the potential of sports for positive social impact. This study investigates whether such responses are influenced by systematic biases.Design/methodology/approachReplicating a Nielsen national survey, two experiments explore whether biases affect support for athletes' participation in the Black Lives Matter (BLM) movement. The study also examines partisan motivated reasoning as a factor driving sports fans' support for BLM.FindingsWhile avid fans display stronger endorsement of BLM compared to causal/non-sports fans, evidence suggests that systematic biases distort these responses. When sport identity becomes salient, reported support for the BLM movement becomes inflated.Research limitations/implicationsResearchers often employ self-report surveys to gauge audience perceptions of athlete activism or cause-related initiatives, particularly when assessing their impact. This study's findings indicate that this context is susceptible to SDB.Originality/valueThe study underscores the role of systematic biases in self-report surveys, particularly in socially desirable contexts. People tend to over-report “positive behavior,” leading survey participants to respond more favorably to questions that are socially desirable. Therefore, interpreting survey results with caution becomes essential when the research context is deemed socially (un)desirable. It is crucial for researchers to apply appropriate measures to identify and mitigate systematic response biases. The authors recommend that researchers adopt both procedural and statistical remedies to detect and reduce social desirability biases.
Bracing community in rural coworking: emerging trends and categories
Authors: Sánchez-Vergara José Ignacio , Orel Marko , Ferreira Valeria , Rus Andrej 
Published: December 2023

Purpose
The objective of this study is to explore the concept of rural coworking in the scientific literature and examine how it generates community narratives based on the value of space and business practices. This study aims to contribute to the understanding of rural coworking as a driver of participation and relationships among diverse stakeholders.

Design/methodology/approach
To identify and analyse trends and categories in rural coworking studies, understand the concept of rural coworking and how community narratives have been focused, the authors carried out a systematic literature review following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) tool. The review was performed using Scopus, obtaining 22 papers.

Findings
The findings reveal that rural coworking is on definition, but it emphasises the role of community as a main actor in its consolidation. On the other hand, rural coworking is seen as an opportunity to create impactful new business strategies through space regeneration and revitalisation. Management perspectives prevail in this research field, highlighting the role of public administrations, entrepreneurs and policymakers, and their capacities to build a business environment to enhance coworking activity.

Originality/value
The paper establishes conceptual categories and research trends in the rural coworking literature, and how its actors have a strategic importance in defining their own practices and narratives. The interrelationship between coworking activity and local business development is continually seen as an opportunity for growth, so this paper will have value for rural coworking planners and consultants in non-urban areas.
Transaction-based lending and real earnings management
Authors: Gray Stephen , Premti Arjan 
Published: December 2023

Purpose The purpose of this study is to examine how lenders alter their behavior when faced with real earnings management.Design/methodology/approach This study uses the incremental R-square approach as in Kim and Kross (2005) to examine how much lenders rely on income statement and balance sheet ratios as the degree of real earnings management increases.Findings As real earnings management affects mostly the income statement, the authors find that lenders rely less on income statement ratios in making credit decisions in the presence of real earnings management. The authors also find that lenders do not alter their reliance on balance sheet ratios when faced with real earnings management.Originality/value This paper is the first to study how lenders alter their reliance on financial statements in making credit decisions in the presence of real earnings management. The findings of this paper could help the regulators set standards to improve the usefulness of financial statements. The findings of this paper could also help practitioners (borrowers and lenders) understand how real earnings management affects credit decisions.
Participation in mental health takaful schemes in Malaysia: perspectives of young intellectuals
Authors: Amin Hanudin 
Published: December 2023

Purpose
This study examined the participation in mental health takaful schemes among young intellectuals in two public universities in Malaysia.

Design/methodology/approach
Drawing from the Attitude-Social Influence-Self-Efficacy (ASE), this study evaluated the effects of attitude, social influence and self-efficacy on participation in mental health takaful schemes using an empirical investigation surveying 767 respondents who were identified as young intellectuals in Malaysia.

Findings
Evidently, the ASE factors shape the development of participation in mental health takaful schemes among young intellectuals.

Research limitations/implications
This study is confined in terms of the context and variables used – which limits its generalisation. Future studies should address these issues accordingly.

Practical implications
The results obtained can become a yardstick to gauge the participation of young intellectuals in mental health takaful in Malaysia.

Originality/value
This study introduced mental health takaful to the ASE, where young intellectuals are brought into play.
Vogt‐Koyanagi‐Harada disease‐like uveitis after drug therapy including BRAF/MEK inhibitors in melanoma patients with HLA‐DRB1*04
Authors: Amagai Ryo , Fujimura Taku , Yamazaki Emi , Takahashi Manami , Tamabuchi Erika , Kambayashi Yumi , Hashimoto Akira , Hashimoto Kazuki , Asano Yoshihide 
Published: December 2023

AbstractThe combination of BRAF kinase inhibitors (BRAFis) and MEK kinase inhibitors (MEKis) is one of the most promising chemotherapy regimens in the treatment of BRAF‐mutant melanoma. Although BRAFi plus MEKi combined therapy is widely used for the treatment of BRAFV600‐mutated melanoma, the incidence of uveitis caused by BRAFi plus MEKi is limited. In this report, we described five cases (two men and three women) of Vogt‐Koyanagi‐Harada (VKH) disease‐like uveitis in melanoma patients who received BRAFi plus MEKi combined therapy. Of note, all the patients had the HLA‐DRB1*04 haplotype, which is frequently detected in VKH‐like non‐infectious uveitis. On the other hand, among BRAFi plus MEKi‐treated patients who did not develop VKH disease‐like uveitis, only one of five (20%) patients had the HLA‐DRB1*04 haplotype. Collectively, BRAFi/MEKi might induce severe VKH disease‐like uveitis in melanoma patients with the HLA‐DRB1*04 haplotype.
Recruitment, retention, and experiences of Australian male dietitians: A cross‐sectional online survey
Authors: Stefoska‐Needham Anita , Weber Christopher M. , Beck Eleanor J. , Craddock Joel C. , Houston Lauren A. 
Published: December 2023

AbstractAimMale dietitians are under‐represented in the global dietetics workforce, including in Australia. This study explores Australian males' experiences as dietitians in the Australian workforce, with the aim to identify influences that initially attracted them to dietetics, as well as barriers that may affect their decision to stay in or leave the profession.MethodsA cross‐sectional, semi‐quantitative web‐based survey was distributed to male dietitians using purposive, snowball sampling. Closed and open‐ended questions were included. Descriptive statistics were generated, and content analysis of free‐text responses identified major themes.ResultsSeventy‐one respondents opened the survey link, of which 65 respondents attempted the survey. Fifty‐four (83.1%) respondents agreed that dietetics is female‐dominated. An interest in food and nutrition was the most reported reason for studying dietetics (73.8%). Of the 55 respondents who were not intending to retire in the next 5 years, 15 (27.3%) stated they were somewhat or extremely likely to leave the profession of dietetics. Respondents identified issues that impacted their experiences as a male dietitian, including gender differences, a lack of male role models, barriers to career progression/employment, and perceptions of a lack of respect and impact within healthcare.ConclusionsAustralian male dietitians perceive systemic, social, and personal factors that have influenced their career experiences. Greater exposure to prominent male role models may be self‐perpetuating in improving male dietitian recruitment and eventually, retention. A multi‐pronged approach is needed to improve the rate of recruitment of male dietitians, with a role for tertiary education providers and peak dietetics bodies.
Polymorphisms in the A118G SNP of the OPRM1 gene produce different experiences of opioids: A human laboratory phenotype–genotype assessment
Authors: Dunn Kelly E. , Huhn Andrew S. , Finan Patrick H. , Mange Ami , Bergeria Cecilia L. , Maher Brion S. , Rabinowitz Jill A. , Strain Eric C. , Antoine Denis 
Published: December 2023

AbstractAllelic variations in the A118G SNP of the OPRM1 gene change opioid signaling; however, evaluations of how allelic differences may influence opioid effects are lacking. This human laboratory paradigm examined whether the AA versus AG/GG genotypes determined opioid response profiles. Individuals with limited opioid exposure (N = 100) completed a five‐day within‐subject, double‐blind, placebo‐controlled, residential study. Participants were admitted (Day 1), received 4 mg hydromorphone (Day 2) and 0 mg, 2 mg and 8 mg hydromorphone in randomized order (Days 3–5) and completed self‐reported visual analog scale (VAS) ratings and Likert scales, observed VAS, and physiological responses at baseline and for 6.5 h post‐dose. Outcomes were analysed as peak/nadir effects over time as a function of genotype (available for N = 96 individuals; AG/GG = 13.5%, AA = 86.4%). Participants with AG/GG rated low and moderate doses of hydromorphone as significantly more positive (e.g., Good Effects VAS, coasting, drive, friendly, talkative, stimulation) with fewer negative effects (e.g., itchy skin, nausea, sleepiness), and were also observed as being more talkative and energetic relative to persons with AA. Persons with AG/GG were less physiologically reactive as determined by diastolic blood pressure and heart rate, but had more changes in core temperature compared with those with AA. Persons with AA also demonstrated more prototypic agonist effects across doses; persons with AG/GG showed limited response to 2 mg and 4 mg. Data suggest persons with AG/GG genotype experienced more pleasant and fewer unpleasant responses to hydromorphone relative to persons with AA. Future studies should replicate these laboratory findings in clinical populations to support a precision medicine approach to opioid prescribing.
A network‐based approach to understanding gene–biological processes affecting economically important traits of Nelore cattle
Authors: Corrêa Mariely Simone Lopes , Silva Evandro Neves , dos Santos Thaís Cristina Ferreira , Simielli Fonseca Larissa Fernanda , Magalhães Ana Fabrícia Braga , Verardo Lucas Lima , de Albuquerque Lucia Galvão , Silva Danielly Beraldo dos Santos 
Published: December 2023

AbstractThis study aimed to build gene–biological process networks with differentially expressed genes associated with economically important traits of Nelore cattle from 17 previous studies. The genes were clustered into three groups by evaluated traits: group 1, production traits; group 2, carcass traits; and group 3, meat quality traits. For each group, a gene–biological process network analysis was performed with the differentially expressed genes in common. For production traits, 37 genes were found in common, of which 13 genes were enriched for six Gene Ontology (GO) terms; these terms were not functionally grouped. However, the enriched GO terms were related to homeostasis, the development of muscles and the immune system. For carcass traits, four genes were found in common. Thus, it was not possible to functionally group these genes into a network. For meat quality traits, the analysis revealed 222 genes in common. CSRP3 was the only gene differentially expressed in all three groups. Non‐redundant biological terms for clusters of genes were functionally grouped networks, reflecting the cross‐talk between all biological processes and genes involved. Many biological processes and pathways related to muscles, the immune system and lipid metabolism were enriched, such as striated muscle cell development and triglyceride metabolic processes. This study provides insights into the genetic mechanisms of production, carcass and meat quality traits of Nelore cattle. This information is fundamental for a better understanding of the complex traits and could help in planning strategies for the production and selection systems of Nelore cattle.
Population size and conservation status of large terrestrial mammals in a West African protected area
Authors: Mohammed Umar Lawal , Mohd Sah Shahrul Anuar 
Published: December 2023

AbstractTerrestrial large mammals are threatened in West and Central Africa due to trade and consumption. The species population size was estimated using diurnal distance sampling in Old Oyo National Park, Nigeria. Mean species abundance and density ranged from 631 ± 281 to 3320 ± 1163 individuals and 2.0661 ± 1.356 to 6.7525 ± 3.0376 individuals km−2 between sub‐habitat types, and from 258 ± 125 to 2671 ± 867 individuals and 0.9526 ± 0.6801 to 5.1377 ± 1.8988 individual km−2 between the ranges. Based on IUCN guidelines for local assessment, we classified 1 species as Vulnerable, 10 Near Threatened and 1 Least Concern. Long‐term population monitoring and education programmes are crucial.
Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy
Authors: Voskamp Astrid L. , Khosa Sugandhika , Phan Tracy , DeBerg Hannah A. , Bingham Judy , Hew Mark , Smith William , Abramovitch Jodie , Rolland Jennifer M. , Moyle Matthew , Nadeau Kari C. , Lack Gideon , Larché Mark , Wambre Erik , O'Hehir Robyn E. , Hickey Pascal , Prickett Sara R. 
Published: December 2023

AbstractBackgroundFood allergy is a leading cause of anaphylaxis worldwide. Allergen‐specific immunotherapy is the only treatment shown to modify the natural history of allergic disease, but application to food allergy has been hindered by risk of severe allergic reactions and short‐lived efficacy. Allergen‐derived peptides could provide a solution. PVX108 comprises seven short peptides representing immunodominant T‐cell epitopes of major peanut allergens for treatment of peanut allergy.MethodsPre‐clinical safety of PVX108 was assessed using ex vivo basophil activation tests (n = 185). Clinical safety and tolerability of single and repeat PVX108 doses were evaluated in a first‐in‐human, randomized, double‐blind, placebo‐controlled trial in peanut‐allergic adults (46 active, 21 placebo). The repeat‐dose cohort received six doses over 16 weeks with safety monitored to 21 weeks. Exploratory immunological analyses were performed at pre‐dose, Week 21 and Month 18 after treatment.ResultsPVX108 induced negligible activation of peanut‐sensitised basophils. PVX108 was safe and well tolerated in peanut‐allergic adults. There were no treatment‐related hypersensitivity events or AEs of clinical concern. The only events occurring more frequently in active than placebo were mild injection site reactions. Exploratory immunological analyses revealed a decrease in the ratio of ST2+ Th2A:CCR6+ Th17‐like cells within the peanut‐reactive Th pool which strengthened following treatment.ConclusionThis study supports the concept that PVX108 could provide a safe alternative to whole peanut immunotherapies and provides evidence of durable peanut‐specific T‐cell modulation. Translation of these findings to clinical efficacy in ongoing Phase 2 trials would provide important proof‐of‐concept for using peptides to treat food allergy.
Alemtuzumab‐induced immune‐mediated thrombotic thrombocytopenic purpura: A newly described drug‐related autoimmune disease
Authors: Bourdin V. , Fossé Q. , Lambotte O. , Joly B. , Coppo P. , Anguel N. , Labeyrie C. 
Published: December 2023

SummaryImmune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and life‐threatening disease that may result from drug exposure. We report a case of iTTP occurring in a 39‐year‐old patient, 45 months following introduction of the anti‐CD52 lymphoid cell depleting monoclonal antibody alemtuzumab, to treat a relapsing‐remitting multiple sclerosis. Treatment consisted in plasma exchange, corticosteroids and caplacizumab, allowing clinical remission 3 months after the diagnosis, attested by the absence of thrombocytopenia and recovery of ADAMTS‐13 activity. As other autoimmune disorders, iTTP may occur following alemtuzumab. This diagnosis should be suspected in patients with features of thrombotic microangiopathy following this treatment.
Avoiding novel, unwanted interactions among species to decrease risk of zoonoses
Authors: Galindo‐González Jorge 
Published: December 2023

AbstractCircumstances that precipitate interactions among species that have never interacted during their evolutionary histories create ideal conditions for the generation of zoonoses. Zoonotic diseases have caused some of the most devastating epidemics in human history. Contact among species that come from different ecosystems or regions creates the risk of zoonoses. In certain situations, humans are generating and promoting conditions that contribute to the creation of infectious diseases and zoonoses. These conditions lead to interactions between wildlife species that have hitherto not interacted under normal circumstances. I call for recognition of the zoonotic potential that novel and unwanted interactions have; identification of these new interactions that are occurring among wild animals, domestic animals, and humans; and efforts to stop these kinds of interactions because they can give rise to zoonotic outbreaks. Live animal markets, the exotic pet trade, illegal wildlife trade, human use and consumption of wild animals, invasive non‐native species, releasing of exotic pets, and human encroachment in natural areas are among the activities that cause the most interactions among wild species, domestic species, and humans. These activities should not occur and must be controlled efficiently to prevent future epidemic zoonoses. Society must develop a keen ability to identify these unnatural interactions and prevent them. Controlling these interactions and efficiently addressing their causal factors will benefit human health and, in some cases, lead to positive environmental, ethical, and socioeconomic outcomes. Until these actions are taken, humanity will face future zoonoses and zoonotic pandemic.
Intelligent IoT framework with GAN‐synthesized images for enhanced defect detection in manufacturing
Authors: Aramkul Somrawee , Sugunnasil Prompong 
Published: December 2023

AbstractThe manufacturing industry is always exploring techniques to optimize processes, increase product quality, and more accurately identify defects. The technique of deep learning is the strategy that will be used to handle the issues presented. However, the challenge of using AI in this domain is the small and imbalanced dataset for training affected by the severe shortage of defective data. Moreover, data acquisition requires significant labor, time, and resources. In response to these demands, this research presents an intelligent internet of things (IoT) framework enriched by generative adversarial network (GAN). This framework was developed in response to the needs outlined above. The framework applies the IoT for real‐time data collection and communication, while GAN are utilized to synthesize high‐fidelity images of manufacturing defects. The quality of the GAN‐synthesized image is quantified by the average FID score of 8.312 for non‐defective images and 7.459 for defective images. As evidenced by the similarity between the distributions of synthetic and real images, the proposed generative model can generate visually authentic and high‐fidelity images. As demonstrated by the results of the defect detection experiments, the accuracy can be enhanced to the maximum of 96.5% by integrating the GAN‐synthesized images with the real images. Concurrently, this integration reduces the occurrence of false alarms.
Fitness effects of assisted gene flow in an endangered salmonid population
Authors: Klemme Ines , Pysäys Joonas , Hyvärinen Pekka , Karvonen Anssi 
Published: December 2023

AbstractAssisted gene flow is increasingly used to combat severe population declines. However, the associated risks, such as outbreeding depression, are often insufficiently assessed. Here, we studied the impact of assisted gene flow on the fitness of a highly endangered landlocked salmon population (Salmo salar m. sebago) from the lake Saimaa complex (Finland), using an anadromous Atlantic salmon population (S. salar) as donor. We released individuals of both parental populations and their hybrids into seminatural streams, monitoring their survival under predation risk from Northern pike (Esox lucius) and their growth on a natural diet. Before release, we exposed half of the salmon to the parasite Diplostomum pseudospathaceum to study whether assisted gene flow affects infection susceptibility, which could indirectly shape predation susceptibility and growth. The parental populations differed in both studied traits and the hybrids showed intermediate values. Relative to the target landlocked salmon population, hybrids experienced 21–26% lower survival, but 1.4–2.2% higher growth. They also carried 0.6–2.8 more parasites than the landlocked salmon, contributing to survival differences. These findings indicate that assisted gene flow can induce both negative and positive fitness effects. We propose that the overall net effects of this conservation tool need to be carefully evaluated before its implementation.