bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for inguinal hernia repair among US adults
Authors: Cowan B. , Kvale M. , Yin J. , Patel S. , Jorgenson E. , Mostaedi R. , Choquet H. 
Published: November 2023

Abstract
Purpose
To investigate demographic, clinical, and behavioral risk factors for undergoing inguinal hernia repair within a large and ethnically diverse cohort.

Methods
We conducted a retrospective case–control study from 2007 to 2020 on 302,532 US individuals from a large, integrated healthcare delivery system with electronic health records, who participated in a survey of determinants of health. Participants without diagnosis or procedure record of an inguinal hernia at enrollment were included. We then assessed whether demographic (age, sex, race/ethnicity), clinical, and behavioral factors (obesity status, alcohol use, cigarette smoking and physical activity) were predictors of undergoing inguinal hernia repair using survival analyses. Risk factors showing statistical significance (P < 0.05) in the univariate models were added to a multivariate model.

Results
We identified 7314 patients who underwent inguinal hernia repair over the study period, with a higher incidence in men (6.31%) compared to women (0.53%). In a multivariate model, a higher incidence of inguinal hernia repair was associated with non-Hispanic white race/ethnicity, older age, male sex (aHR = 13.55 [95% confidence interval 12.70–14.50]), and more vigorous physical activity (aHR = 1.24 [0.045]), and alcohol drinker status (aHR = 1.05 [1.00–1.11]); while African-American (aHR = 0.69 [0.59–0.79]), Hispanic/Latino (aHR = 0.84 [0.75–0.91]), and Asian (aHR = 0.35 [0.31–0.39]) race/ethnicity, obesity (aHR = 0.33 [0.31–0.36]) and overweight (aHR = 0.71 [0.67–0.75]) were associated with a lower incidence. The use of cigarette was significantly associated with a higher incidence of inguinal hernia repair in women (aHR 1.23 [1.09–1.40]), but not in men (aHR 0.96 [0.91–1.02]).

Conclusion
Inguinal hernia repair is positively associated with non-Hispanic white race/ethnicity, older age, male sex, increased physical activity, alcohol consumption and tobacco use (only in women); while negatively associated with obesity and overweight status. Findings from this large and ethnically diverse study may support future prediction tools to identify patients at high risk of this surgery.
Symmetric-conjugate splitting methods for linear unitary problems
Authors: Bernier J. , Blanes S. , Casas F. , Escorihuela-Tomàs A. 
Published: November 2023

AbstractWe analyze the preservation properties of a family of reversible splitting methods when they are applied to the numerical time integration of linear differential equations defined in the unitary group. The schemes involve complex coefficients and are conjugated to unitary transformations for sufficiently small values of the time step-size. New and efficient methods up to order six are constructed and tested on the linear Schrödinger equation.
Winter Wheat Crop Models Improve Growth Simulation by Including Phenological Response to Water-Deficit Stress
Authors: Mankin Kyle R. , Edmunds Debora A. , McMaster Gregory S. , Fox Fred , Wagner Larry E. , Green Timothy R. 
Published: November 2023

AbstractCrop models can provide insights into the impacts of climate and management on crop growth and yield, but most currently are limited by overly simplistic assumptions about phenological development and response to water stress. We assessed winter wheat growth and yield performance of three crop models with lineage to the EPIC crop submodel. SWAT adopted the EPIC approach with few modifications, WEPS added new biomass accumulation, partitioning, and canopy approaches linked to key phenological development stages, and UPGM added to WEPS a detailed phenology component simulating responses to water-deficit stress. The models were evaluated with default parameters and compared to experimental data for winter wheat (Triticum aestivum L.) from two sites and a range of water-stress conditions for yield, aboveground biomass, biomass partitioning, canopy height, harvest index, and leaf area index. All models simulated yield very well (index of agreement [d] ≥ 0.93), but differences in model performance were increasingly evident for biomass (d = 0.91 [WEPS] to 0.86 [SWAT]), final canopy height (d = 0.68 [UPGM] to 0.44 [SWAT]), and harvest index (d = 0.61 [WEPS] to 0.43 [SWAT]). Errors in biomass simulation were most evident in the grain-filling period late in the growing season. Both WEPS and UPGM exhibited improved simulation of biomass and other response variables by including more explicit simulation of phenological response to water stress. The consistent improvement in winter wheat growth and yield simulation achieved with detailed phenology simulation provides an incentive to develop and test detailed phenology simulation components for other crops: currently 11 crops are simulated in UPGM, although the phenological parameters are uncalibrated. Better modeling linkages of water-stressed phenological development with other physiological processes will be critical to inform crop production where water stress and irrigation limitation are concerns.
Design and Implementation of an Automated Classroom Analytics System: Stakeholder Engagement and Mapping
Authors: Baran Evrim , AlZoubi Dana , Morales Anasilvia Salazar 
Published: November 2023

AbstractComputational analysis methods and machine learning techniques introduce innovative ways to capture classroom interactions and display data on analytics dashboards. Automated classroom analytics employ advanced data analysis, providing educators with comprehensive insights into student participation, engagement, and behavioral trends within classroom settings. Through the provision of context-sensitive feedback, automated classroom analytics systems can be integrated into the evidence-based pedagogical decision-making and reflective practice processes of faculty members in higher education institutions. This paper presents TEACHActive, an automated classroom analytics system, by detailing its design and implementation. It outlines the processes of stakeholder engagement and mapping, elucidates the benefits and obstacles associated with a comprehensive classroom analytics system design, and concludes by discussing significant implications. These implications propose user-centric design approaches for higher education researchers and practitioners to consider.
Hemodynamic predictors of negative false lumen remodeling after frozen elephant trunk for acute aortic dissection
Authors: Takei Yusuke , Miyazaki Shohei , Suzuki Kohei , Saito Shunsuke , Oogaki Hayato , Muraoka Yuki , Ogasawara Takeshi , Tezuka Masahiro , Shibasaki Ikuko , Fukuda Hirotsugu 
Published: November 2023

Abstract
Objective
We evaluated the blood flow within the downstream aortic false lumen after frozen elephant trunk repair for acute aortic dissection and identified hemodynamic predictors of false lumen expansion and negative false lumen remodeling using four-dimensional flow magnetic resonance imaging.

Methods
Thirty-one patients (Stanford type A, n = 28; Stanford type B, n = 3) with patent false lumen who underwent frozen elephant trunk procedures for acute aortic dissection were included in this observational study. Each patient underwent computed tomography during the follow-up period and four-dimensional flow magnetic resonance imaging within 3 postoperative months. The false lumen volumetric expansion rate was calculated using computed tomography data. The direction and the rate of flow in the lower descending aortic false lumen were analyzed. Negative false lumen remodeling was defined as a volumetric increase of > 10% from the baseline volume.

Results
Negative false lumen remodeling had developed in 6 of the 31 patients during the observation period. Most of the false lumen flows were biphasic during systole. The range between peak and nadir flow rates was associated with the false lumen volumetric expansion rate (β coefficient = 6.77; p < 0.01, R2 = 0.43).

Conclusions
The range between peak and nadir flow rates may serve as a hemodynamic predictor of negative false lumen remodeling, enabling further treatment for patients at risk of expansion in the downstream aorta.
A model to predict delivery time following induction of labor at term with a dinoprostone vaginal insert: a retrospective study
Authors: Huang Fenghua , Chen Huijun , Wu Xuechun , Li Jiafu , Guo Juanjuan , Zhang Xiaoqin , Qiao Yuan 
Published: November 2023

Abstract
Background
Dinoprostone vaginal insert is the most common pharmacological method for induction of labor (IOL); however, studies on assessing the time to vaginal delivery (DT) following dinoprostone administration are limited.

Aims
We sought to identify the primary factors influencing DT in women from central China, at or beyond term, who underwent IOL with dinoprostone vaginal inserts.

Methods
In this retrospective observational study, we analyzed the data of 1562 women at 37 weeks 0 days to 41 weeks 6 days of gestation who underwent dinoprostone-induced labor between January 1st, 2019, and December 31st, 2021. The outcomes of interest were vaginal or cesarean delivery and factors influencing DT, including maternal complications and neonatal characteristics.

Results
Among the enrolled women, 71% (1109/1562) delivered vaginally, with median DT of 740.50 min (interquartile range 443.25 to 1264.50 min). Of the remaining 29% (453/1562), who delivered by cesarean section, 11.9% (54/453) were multiparous. Multiple linear regression analysis showed that multiparity, advanced maternal age, fetal macrosomia, premature rupture of membranes (PROM), and daytime insertion of dinoprostone were the factors that significantly influenced DT. Time to vaginal delivery increased with advanced maternal age and fetal macrosomia and decreased with multiparity, PROM, and daytime insertion of dinoprostone. A mathematical model was developed to integrate these factors for predicting DT: Y = 804.478 − 125.284 × multiparity + 765.637 × advanced maternal age + 411.511 × fetal macrosomia-593.358 × daytime insertion of dinoprostone − 125.284 × PROM.

Conclusions
Our findings may help obstetricians estimate the DT before placing a dinoprostone insert, which may improve patient management in busy maternity wards and minimize potential risks.
Influence of the Cellular Ultrastructure and Enzyme Activity of the Leaf Sheath on Spontaneous Defoliation in Sugarcane
Authors: Hu Xin , Wang Tiantian , Liu Shaochun , Guo Jiawen , Dao Jingmei , Gao Xinxin , Li Rudan , Liu Gaoyuan 
Published: November 2023

AbstractSpontaneous defoliation improves the harvesting efficiency and yield of sugarcane. Here, we investigated the ultrastructural changes and pectinase and cellulase activity in the third, fifth, and seventh leaf sheaths in four sugarcane varieties with varying spontaneous defoliation performance during maturation. At the early and middle stages of spontaneous defoliation, the cells in the abscission zones of the third, fifth, and seventh leaf sheaths were degrading. At the late stage, no complete organelles and hollow or broken spots in the cell walls were observed in the abscission zone cells of defoliation-prone varieties, while complete organelles and intact cell walls were present in the abscission zone cells at the same leaf positions in defoliation-resistant varieties. From the early to late stages, defoliation-prone varieties had higher pectinase activity in the abscission zones of the fifth and seventh leaf sheaths. At the early stage of defoliation, defoliation-prone varieties had significantly higher cellulase activity in the abscission zones of the third, fifth, and seventh leaf sheaths. Correlation analysis showed that the spontaneous defoliation rate was significantly positively correlated with pectinase activity in the leaf sheaths. In conclusion, the spontaneous defoliation of sugarcane was closely related to changes in cell morphology and pectinase activites in leaf sheaths.
Focal therapy in intermediate- and high-risk prostate cancer
Authors: Huebner Nicolai A. , Korn Stephan , Rajwa Pawel , Shariat Shahrokh F. 
Published: November 2023

SummaryFocal therapy is a treatment option for clinically localized prostate cancer, finding increased use in recent years. It is generally associated with very good functional outcome regarding pad-free continence and preservation of erections. Oncologic outcomes are controversial, especially depending on the ideal endpoint. Both the presence of clinically significant prostate cancer (csPCA) on biopsy and the absence of any whole-gland or systemic treatment as “failure-free survival” (FFS) have been used. While salvage whole-gland and systemic therapy is rare, a substantial number of patients will have csPCA on follow-up biopsies after focal therapy, either in-field or out of field. Generally, patients selected for focal therapy are considered intermediate-risk, although some patients with high-risk features have been included into focal therapy studies. With the data currently available focal therapy presents a good treatment option for patients with feasible intermediate-risk prostate cancer, interested in functional outcome, after proper counseling on the higher recurrence rate, and the need for surveillance biopsies during follow-up.
The Neuroimmune System and the Cerebellum
Authors: Gruol Donna L. 
Published: November 2023

AbstractThe recognition that there is an innate immune system of the brain, referred to as the neuroimmune system, that preforms many functions comparable to that of the peripheral immune system is a relatively new concept and much is yet to be learned. The main cellular components of the neuroimmune system are the glial cells of the brain, primarily microglia and astrocytes. These cell types preform many functions through secretion of signaling factors initially known as immune factors but referred to as neuroimmune factors when produced by cells of the brain. The immune functions of glial cells play critical roles in the healthy brain to maintain homeostasis that is essential for normal brain function, to establish cytoarchitecture of the brain during development, and, in pathological conditions, to minimize the detrimental effects of disease and injury and promote repair of brain structure and function. However, dysregulation of this system can occur resulting in actions that exacerbate or perpetuate the detrimental effects of disease or injury. The neuroimmune system extends throughout all brain regions, but attention to the cerebellar system has lagged that of other brain regions and information is limited on this topic. This article is meant to provide a brief introduction to the cellular and molecular components of the brain immune system, its functions, and what is known about its role in the cerebellum. The majority of this information comes from studies of animal models and pathological conditions, where upregulation of the system facilitates investigation of its actions.
Consumers’ perceptions of food fraud in selected Southeast Asian countries: a cross sectional study
Authors: Soon-Sinclair Jan Mei , Ha Thanh Mai , Vanany Iwan , Limon Mark Raguindin , Sirichokchatchawan Wandee , Abdul Wahab Ikarastika Rahayu , Hamdan Ruhil Hayati , Jamaludin Mohd Hafiz 
Published: November 2023

AbstractSoutheast Asia is projected to be the fourth largest economy in 2050, where agriculture and food are key sectors contributing to the regional’s GDP. However, ensuring food safety and traceability remains a challenge in the region and this offers ripe opportunity for fraudsters to take advantage of the system. This study aims to provide an overview of consumers’ concern about food fraud in selected countries in Southeast Asia. A cross-sectional online survey was implemented in Indonesia, Malaysia, the Philippines, Thailand, and Vietnam, yielding 1393 valid responses. Multiple Correspondence Analysis (MCA) was conducted first to reduce the large dataset containing nominal variables. After that, ordered logistic regression was performed to predict food fraud concern, with independent variables being dimensions derived from MCA, total knowledge and experience, and demographic characteristics. We found that respondents from Vietnam and Malaysia were significantly more worried about food fraud compared to other countries. Concerns about food fraud were influenced by increased demand for food fraud control, perceived risks of different types of food fraud, information sources from media and personal networks, information sources from credible organisations, and self-experience of food fraud. Practical and policy recommendations for the region were suggested. This is the first empirical study on consumers’ concern about food fraud in Southeast Asia. The study embodies the UK Global Food Security and UN Sustainable Development Goal No. 2 ethos of providing the growing global population with access to safe food.
A Data Quality Multidimensional Model for Social Media Analysis
Authors: Aramburu María José , Berlanga Rafael , Lanza-Cruz Indira 
Published: November 2023

AbstractSocial media platforms have become a new source of useful information for companies. Ensuring the business value of social media first requires an analysis of the quality of the relevant data and then the development of practical business intelligence solutions. This paper aims at building high-quality datasets for social business intelligence (SoBI). The proposed method offers an integrated and dynamic approach to identify the relevant quality metrics for each analysis domain. This method employs a novel multidimensional data model for the construction of cubes with impact measures for various quality metrics. In this model, quality metrics and indicators are organized in two main axes. The first one concerns the kind of facts to be extracted, namely: posts, users, and topics. The second axis refers to the quality perspectives to be assessed, namely: credibility, reputation, usefulness, and completeness. Additionally, quality cubes include a user-role dimension so that quality metrics can be evaluated in terms of the user business roles. To demonstrate the usefulness of this approach, the authors have applied their method to two separate domains: automotive business and natural disasters management. Results show that the trade-off between quantity and quality for social media data is focused on a small percentage of relevant users. Thus, data filtering can be easily performed by simply ranking the posts according to the quality metrics identified with the proposed method. As far as the authors know, this is the first approach that integrates both the extraction of analytical facts and the assessment of social media data quality in the same framework.
Pilot plant evaluation of membrane distillation for desalination of high-salinity brines
Authors: Adham Samer , Minier-Matar Joel , Hussain Altaf 
Published: November 2023

AbstractMembrane distillation (MD) is a hybrid thermal-membrane desalination process that can use either low-grade waste heat and/or solar energy with hydrophobic membranes to desalinate high-salinity brines and produce high quality distillate. A research consortium was launched to investigate the application of the MD process, at lab and pilot scale, for desalination of concentrated brines. Bench scale results showed the presence of antiscalants in the concentrated brines minimized the scale precipitation potential and offered stable membrane permeability performance. Various MD technologies were screened, and two suitable technologies were selected for field-testing. Pilot unit A was based on multi-effect vacuum showed a stable flux of 6.2 LMH with excellent salt rejection (> 99.9%) from the concentrated brine discharged from thermal desalination plant in Qatar. That pilot unit was also field tested on hypersaline groundwater in Texas (USA) to generate fresh water for reservoir fracking in unconventional oil production operations. The MD unit was coupled with humidification/dehumidification (HDH) unit to achieve zero liquid discharge (ZLD) for inland applications. The MD unit was operated at 40% recovery producing distillate of < 20 mg/L total dissolved solids (TDS) and observed a stable flux of 5 LMH. Key challenges that are critical for large-scale deployment of MD technology were identified at the end of the field-testing program. Finally, a review of active MD technologies was conducted to highlight recent promising developments for full-scale applications.
Fungi associated with the ambrosia beetle Xyleborus perforans (Coleoptera: Curculionidae: Scolytinae) on drought-stressed Pinus in New South Wales, Australia
Authors: Mahony Zali I , Scarlett Kelly , Carnegie Angus J , Trollip Conrad , Laurence Matthew , Guest David I 
Published: November 2023

AbstractAmbrosia beetles have co-evolved symbiotic relationships with an array of fungal partners. Mutualistic fungal partners are often highly successful in vertical transmission between beetle generations. These persisting relationships can alter beetle behaviour, resulting in the opportunity to occupy new ecological niches and to spread geographically. In Australia, ambrosia beetles are not currently considered a significant pest in commercial Pinus plantations, where the bark beetle Ips grandicollis is known as the primary invader of stressed trees. However, in 2019, ambrosia beetles Xyleborus perforans and X. bispinatus, co-occurring with I. grandicollis, were found to have colonised a large proportion of drought-stressed trees in commercial Pinus plantations in north-east New South Wales. In this study, X. perforans (the most prevalent of two Xyleborus spp.) was collected from infested dead and dying trees in two NSW Pinus plantations. Fungal isolates of suspected Pinus pathogens were recovered from beetle mycangia and exoskeletons as well as ambrosia beetle galleries. Morphological examination and multilocus sequence analysis identified five fungi associated with X. perforans: Fusarium parceramosum, Fusarium aff. solani, Ophiostoma ips, Raffaelea deltoideospora and Sporothrix pseudoabietina. For Australia, this is the first report of F. parceramosum, as well as the first records of O. ips, R. deltoideospora and S. pseudoabietina being vectored by Xyleborus. Pathogenicity tests were performed on seedlings of three Pinus spp., with O. ips producing significantly longer lesions than the other fungi. This study demonstrates the potential for seemingly harmless ambrosia beetles to vector plant pathogens in Australian forests, providing a mode of disease transmission that should be considered in plantation management and forest biosecurity.
The alkynyl-containing compounds from mushrooms and their biological activities
Authors: Qi Ji-shuang , Duan Yingce , Li Zhao-chen , Gao Jin-ming , Qi Jianzhao , Liu Chengwei 
Published: November 2023

AbstractMushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are a crucial natural source of bioactive secondary metabolites, and recent advancements have led to the isolation of several alkynyl-containing compounds with potential medicinal uses. Despite their relatively low abundance, naturally occurring alkynyl compounds have attracted considerable attention due to their high reactivity. Bioactivity studies have shown that alkynyl compounds exhibit significant biological and pharmacological activities, including antitumor, antibacterial, antifungal, insecticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. This review systematically compiles 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarizes their diverse biological activities, focusing mainly on cytotoxicity and anticancer effects. This review serves as a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from mushrooms. Moreover, it provides theoretical support for the development of chemical constituents containing alkynyl compounds in mushrooms based on academic research and theory.
Graphical Abstract