bluuebunny/crossref_metadata_2025_split huggingface dataset:
Text Mining - Analisis Teks Terkait Isu Vaksinasi COVID-19 (Text Mining - Text Analysis Related to COVID-19 Vaccination Issues)
Authors: Anggraini Novita , Harahap Edi Surya Negara , Kurniawan Tri Basuki 
Published: January 2024

Sebagai langkah untuk dapat mengurangi penularan COVID-19, pemerintah tengah menggalakkan program vaksinasi sehingga tercapainya herd immunity. Disebabkan kegagalan vaksinasi sebelumnya, sebagian besar masyarakat menolak dengan keras adanya vaksinasi, hal ini sangat disayangkan karena terjadi kegaduhan ditengah–tengah masyarakat. Dalam proses menarik kembali kepercayaan masyarakat, pemerintah mecoba menyebaran luaskan informasi vaksinasi lewat media sosial (instagram), kemudian inilah yang menjadi daya tarik peneliti untuk mengeksplorasi lebih lanjut proses vaksinasi. Dari banyaknya opini masyarakat terdapat beberapa hal yang mungkin masih sulit ditemukan, sebab itulah perlunya analisis teks. Analisis teks dilakukan bertujuan melihat term rangking dan informasi lainnya dengan metode Rule-based Sentiment Analysis. TF-IDF & LSI/LSA adalah jenis metode rule mining yang digunakan dalam penerapan ektrasi informasi. Hasil analisis penelitian ini kemungkinan mempengaruhi informasi lainnya. Seperti analisis persepsi pengguna digunakan untuk melihat gambaran lebih luas tentang isu atau topik pembicaraan penting, serta titik temu permasalahan berkaitan dengan vaksinasi COVID-19.
Analysis of Student Mastery of Concept on Static Fluid Through the Guided Inquiry Flipped Classroom Model
Authors: Azhari Sofia , Yuliati Lia , Kusairi Sentot 
Published: January 2024

This study aimed to analyze students' concept acquisition of static fluid material in the pressure sub-chapter through the Guided Inquiry Flipped Classroom (GIFC) model. This type of research is quantitative, using a one-group pretest-posttest research design. The research subjects consisted of 31 students of XI MIPA 4. The measurement instrument in this study was a concept acquisition test, which consisted of 3 essay questions. Two supervisors have guided the instruments used, and they are valid. The data analysis technique uses paired t-test analysis and effect size analysis. The results of this study indicate significant differences between the pretest and posttest by the results of the paired t-test analysis and that guided inquiry affects concept acquisition. This study implies that this guided inquiry flipped classroom effectively improves students' concept acquisition. The results of this study can be used as input for educators to use the GIFC model to improve students' concept acquisition.
Effectiveness of Guided Inquiry Model in Enhancing Students' Critical Thinking on Light Waves
Authors: Lindriani Sucy , Suwarna Iwan Permana 
Published: January 2024

This study examines how guided inquiry learning can be applied to the material of light waves in physics subjects. This study investigates the potential for increasing students' critical thinking skills. The research method used was a quasi-experimental design, creating the same conditions for the experimental and control groups in other aspects except for particular interventions in the experimental class. This research involved 60 samples of class XI high school students. The sample was divided into two groups (experimental and control) of 30 students each. The research data were obtained through pre-test and post-test from critical thinking instruments containing ten essay-type questions (validated, with validity 0.78 and reliability 0.96). Data were analyzed by parametric t-test on n-gain scores for each group. The results showed that the experimental group scored 0.526 and the control group 0.148. These results indicate differences due to intervention, where applying the guided inquiry model can significantly encourage the development of student's critical thinking skills. The research implications encourage teachers to apply this learning approach model in improving critical thinking skills so that students can be actively involved in facing complex challenges in everyday life. This study also emphasizes the need for curriculum development to improve critical thinking skills in various subjects.
ANALISIS KESULITAN BELAJAR MATEMATIKA MELALUI PERKULIAHAN LEARNING MANAGEMENT SYSTEM
Authors: Handayani Rukmini , Purnamasari Ratih , Sudarjat Jaja 
Published: January 2024

Tujuan dalam penelitian ini adalah untuk mengetahui bagaimana kesulitan belajar matematika melalui perkuliahan Learning Management System. Subyek penelitian adalah mahasiswa semester 2 dan 4 Program Studi Pendidikan Guru Sekolah Dasar Tahun Akademik 2020/2021 yang mengambil mata kuliah Kajian Geometri Dasar dan Kajian Aljabar Dasar. Lokasi penelitian di Program Studi Pendidikan Guru Sekolah Dasar Fakultas Keguruan dan Ilmu Pendidikan Universitas Pakuan, Ciheuleut, Kota Bogor. Metode penelitian ini deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data penelitian ini dengan angket, wawancara, dan dokumentasi. Berdasarkan hasil temuan dalam penelitian yang sudah diuraikan sebelumnya, maka peneliti dapat menemukan bahwa kesulitan belajar matematika melalui perkuliahan Learning Management System FKIP Universitas yaitu: 1). Mahasiswa kurang fokus pada saat mengikuti perkuliahan daring, 2) Mahasiswa menganggap matematika sebagai mata kuliah yang sulit, 3) Kajian Aljabar materi Matrik merupakan materi yang paling sulit, 4). Mahasiswa mengalami kesulitan dalam memahami materi luas permukaan pada kajian geometri, dan 5) Mahasiswa merasa kesulitan dalam mensubmite tugas karena terkendala sinyal dan kestabilan LMS. Maka disarankan bagi pihak universitas, meningkatkan kestabilan Learning Management System. Untuk dosen pengampu diharapkan dapat menyusun aktivitas perkuliahan pada Learning Management System dengan lebih baik melalui kajian bahan ajar sesuai kebutuhan dan kesulitan belajar matematika mahasiswa.
Kata Kunci : Kesulitan belajar mahasiswa, matematika, Learning Management System
PENGEMBANGAN MEDIA EDUGAME GETAR SIDAQU BERBASIS REMO GAGRAK ANYAR PADA MATA PELAJARAN SENI BUDAYA KELAS V SDN PENJARINGANSARI 2
Authors: Agita Silvina Cahya Agita , Azka Arifin She Fira 
Published: January 2024

Kondisi ketertarikan anak-anak cenderung berdampak pada tradisi sekarang yang bisa menghilangkan kelestarian budaya. Agar kebudayaan tidak lagi ditinggal dan kegiatan belajar mengajar tidak monoton, salah satu cara dengan mengenalkan kearifan lokal dengan menggunakan media pembelajaran Edugame berupa quiz berbasis CAI. Penelitian dan pengembangan ini bertujuan untuk mengetahui kevalidan, kepraktisan, dan keefektifan edugame getar sidaqu berbasis remo gagrak anyar untuk meningkatkan hasil belajar siswa mata pelajaran seni budaya kelas V SDN Penjaringansari 2. Penelitian ini merupakan jenis R & D dengan model penelitian ADDIE. Teknik pengumpulan data menggunakan lembar validasi, observasi, angket, tes. Hasil penelitian menunjukkan kevalidan materi sebesar 90% dan grafis media sebesar 86% dengan kategori sangat valid. Adapun kepraktisan media Edugame Getar Sidaqu berdasarkan keterlaksanaan proses mengajar sebesar 97% dengan kategori sangat baik atau praktis. Keefektifan berdasarkan hasil angket respon siswa mencapai 89% dengan kategori sangat baik.
Kata Kunci : Media Pembelajaran, Edugame, Hasil Belajar
Lecturers’ View towards the Role of English in the Spread of Tafsir Nusantara
Authors: Setyaningrum Anisah 
Published: January 2024

<p class="06IsiAbstrak"><strong>Lecturers’ view towards the role of English in the spread of <em>Tafsir Nusantara.</em></strong> This study aimed at describing and investigating the beliefs of lecturers about the role of English in spreading <em>Tafsir Nusantara</em>. This research is descriptive qualitative study. There are six lecturers who were involved as participants in this study. In collecting the data, the researcher used questionnaires and brief interviews to find out what beliefs the lecturers have about the role of English in the spread of <em>Tafsir Nusantara</em>. From the research data, researcher found various assumptions about the role of English in spreading <em>Tafsir Nusantara </em>which showed that English has an important role in the spread or introducing <em>Tafsir Nusantara</em> to the global world.<em> </em>The findings of this research can be a positive contribution in the development of <em>Tafsir Nusantara</em>.</p><p class="06IsiAbstrak"> </p><p class="06IsiAbstrak">Penelitian ini bertujuan untuk mendeskripsikan dan menginvestigasi pandangan dosen tentang peran bahasa Inggris dalam penyebaran <em>Tafsir Nusantara</em>. Penelitian ini merupakan penelitian kualitatif deskriptif. Ada enam dosen yang terlibat sebagai partisipan dalam penelitian ini. Dalam mengumpulkan data, peneliti menggunakan questionnaire dan wawancara singkat untuk mengetahui keyakinan apa yang dimiliki para dosen tentang peran bahasa Inggris dalam menyebarkan <em>Tafsir Nusantara</em>. Dari data penelitian tersebut, peneliti menemukan berbagai asumsi tentang peran bahasa Inggris dalam menyebarkan <em>Tafsir Nusantara</em><em> </em>yang menunjukkan pentingnya peran bahasa Inggris dalam penyebaran dan pengenalan Tafsir Nusantara. Temuan penelitian ini dapat menjadi kontribusi positif dalam pengembangan <em>Tafsir Nusantara</em>.</p><p class="05Abstrak"> </p>
Quantifying antibody binding to Fcγ-receptors in malaria immunity
Authors: Feng Gaoqian , Beeson James 
Published: January 2024

Abstract
IgG can opsonise pathogens and mediate binding to Fcγ-receptors (FcγRs) expressed by various innate immune cells to promote antibody-mediated pathogen clearance via mechanisms including opsonic phagocytosis and antibody-dependent cellular cytotoxicity (ADCC). High levels of IgG that bind FcγRs has been associated with protection from malaria. This assay measures FcγR-binding by antigen-specific IgG using recombinant FcγRs in a plate-based method which is suitable for high throughput. The method is suitable for using recombinant proteins or whole malaria parasites in the assays. FcγRIIa and FcγRIIIa/b are low affinity receptors and need to be used as ectodomain dimers in assays in order to achieve good activity in the assays. FcγRI can be used as a monomeric protein.
Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury
Authors: Personius Kirkwood , Mehrotra Pihu , Jablonski James , Toftegard John , Zhang Yali , Shahini Shahryar , Wang Jianmin , Hung Carey , Ellis Reilly , Kayal Gabriella , rajabian Nika , Liu Song , Roballo Kelly , Udin Susan , Andreadis Stelios 
Published: January 2024

Abstract

Peripheral Nerve Injuries (PNI) affect more than 20 million Americans and severely impact quality of life by causing long-term disability. The onset of PNI is characterized by nerve degeneration distal to the nerve injury resulting in long periods of skeletal muscle denervation. During this period, muscle fibers atrophy and frequently become incapable of “accepting” innervation because of the slow speed of axon regeneration post injury. We hypothesize that reprogramming the skeletal muscle to an embryonic-like state may preserve its reinnervation capability following PNI. To this end, we generated a mouse model in which NANOG, a pluripotency-associated transcription factor can be expressed locally upon delivery of doxycycline (Dox) in a polymeric vehicle. NANOG expression in the muscle upregulated the percentage of Pax7+ nuclei and expression of eMYHC along with other genes that are involved in muscle development. In a sciatic nerve transection model, NANOG expression led to upregulation of key genes associated with myogenesis, neurogenesis and neuromuscular junction (NMJ) formation, and downregulation of key muscle atrophy genes. Further, NANOG mice demonstrated extensive overlap between synaptic vesicles and NMJ acetylcholine receptors (AChRs) indicating restored innervation. Indeed, NANOG mice showed greater improvement in motor function as compared to wild-type (WT) animals, as evidenced by improved toe-spread reflex, EMG responses and isometric force production. In conclusion, we demonstrate that reprogramming the muscle can be an effective strategy to improve reinnervation and functional outcomes after PNI.
Aberrant enhanced NLRP3 inflammasomes and cell pyroptosis in the brains of prion infected rodent models are largely associated with the proliferative astrocytes
Authors: Zhou Dong-Hua , Jia Xiao-Xi , Wu Yue-Zhang , Zhang Wei-Wei , Wang Yuan , Liang Dong-Lin , Gao Li-Ping , Xiao Kang , Chen Cao , Dong Xiao-Ping , Shi Qi 
Published: January 2024

Abstract

Neuroinflammation is a common pathological feature in a number of neurodegenerative diseases, which is mediated primarily by the activated glial cells. NLRP3 inflammasomes associated neuroinflammatory response is mostly considered. To investigate the situation of the NLRP3 related inflammation in prion disease, we assessed the levels of the main components of NLRP3 inflammasome and its downstream biomarkers in the scrapie infected rodent brain tissues. The results showed that the transcriptional and expressional levels of NLRP3, caspase1, ASC in the brains of scrapie infected rodents were significantly increased at terminal stage. The increased NLPR3 overlapped morphologically well with the proliferated GFAP-positive astrocytes, but little with microglia and neurons. Using the brain samples collected at the different time-points after infection, we found the NLRP3 signals increased in a time-dependent manner, which were coincidental with the increase of GFAP. Two main downstream cytokines, IL-1β and IL-18, were also upregulated in the brains of prion infected mice. Moreover, the GSDMD levels, particularly the levels of GSDMD-NT, in the prion infected brain tissues were remarkably increased, indicating activation of cell pyroptosis. The GSDMD not only co-localized well with the astrocytes but also with neurons at terminal stage, also showing a time-dependent increase after infection. Those data indicate that NLRP3 inflammasomes were remarkably activated in the infected brains, which is largely mediated by the proliferated astrocytes. Both astrocytes and neurons probably undergo a pyroptosis process, which may help the astrocytes to release inflammatory factors and contribute to neuron death during prion infection.
Survival outcomes in patients undergoing different treatments for small cell endocrine carcinoma of the cervix: a retrospective analysis
Authors: Liu Tong-Yu , Chen Li-Jun , Xu Lin-Yan , Liu Qin-Qing , Lin Shao-Wei , Hu Dan , Huang Rong-Fang , Ji Hai-Zhou , Lin Yu-Zhen , Xie Zuo-Lian , Lin Wan-Zhen , Xie Rong , Li Sang , Sun Yang 
Published: January 2024

Abstract

Background
To identify the optimal primary treatment strategy for small cell neuroendocrine carcinoma of the cervix (SCNECC).
Methods
This retrospective study included consecutive patients who received treatment for stage I-III SCNECC at Fujian Cancer Hospital from February 6, 2006 to July 30, 2019. Relapse-free survival (RFS) was analyzed using multivariate Cox proportional hazard regression. Results are shown as hazard ratio (HR) and 95% confidence interval (CI).
Results
The final analysis included 69 patients. Disease stage, as assessed by the 2018 FIGO criteria, was early (I–IIA) in 34 (49%) patients and advanced (IIB–IIIC) in the remaining 35 (51%) patients. Twenty patients (29%) received curative-intent radiotherapy followed by chemotherapy. The remaining 49 patients received curative surgical resection, followed by adjuvant chemotherapy in 16 (23%) patients or adjuvant chemoradiotherapy in 33 (48%) patients. Forty patients received neoadjuvant therapy prior to curative surgical resection. Within a median follow-up of 100 months (interquartile range: 59–120), recurrence or metastases occurred in 36 patients (52%). In patients with early-stage disease, the median RFS did not differ between patients undergoing curative-intent surgery vs radiotherapy (86 months, 95% CI 63–109 vs 86 months, 95% CI 56–116, P = 0.790). In patients with advanced-stage disease, there was a statistically non-significant trend for shorter median RFS in patients undergoing curative-intent surgery vs radiotherapy (61 months, 95% CI 38–85 vs 88 months, 95% CI 46–130, P = 0.590). In patients undergoing curative-intent surgery, patients with an extensive pathologic response to neoadjuvant chemotherapy had longer RFS than moderate response and minor response (P = 0.033). In multivariate Cox regression analysis, longer RFS was independently associated with extensive pathologic response to neoadjuvant therapy (HR = 0.01, 95% CI 0.00-0.41; P = 0.017) and neoadjuvant therapy (HR = 10.10, 95% CI 1.02–99.78; P = 0.048).
Conclusions
In patients with early-stage SCNECC, RFS did not differ patients undergoing curative-intent radiotherapy vs surgery. For advanced-stage SCNECC, curative-intent radiotherapy followed by chemotherapy seemed to be compatible with better prognosis.
Zebrafish knockout of frk gene shows social impairments relevant to autism and delays brain development by increasing cell proliferation
Authors: Jiang Kewen , Lin Xueting , Wu Jing , Ying Yingchao , Yan Binhong , Wang Jiangping , Zou Jian 
Published: January 2024

Abstract

Fyn-related kinase (FRK) belonging to the Src family of non-receptor protein tyrosine kinases functions during the cell cycle. Here, we reported an autism spectrum disorders (ASD) patient with intragenic mutation of FRK with two other ASD risk genes. Circumventing the barrier of murine model studies, we generated the CRISPR/Cas9-engineered frk−/− zebrafish. We found that frk-knockout led to increased brain sizes. Frk−/− fish exhibited an ASD-like behavior, including impaired social communication, altered anxiety level, and cognitive dysfunction in both larvae and adults, which could be rescued by the transgenic neuron-specific re-expression of frk. GO and KEGG analysis of RNA-sequencing data found that the frk-knockout-induced DEGs were mainly concentrated in processes and functions related to cell metabolisms. PPI network analysis of the detected DEGs suggested that the cyp24a1/tp53 pathway may play a key role in frk-knockout-induced ASD. Furthermore, we found that the numbers of BrdU+ cells were significantly increased in the frk−/− larval brains. Cyp24a1-inhibition or tp53-activation, reduced cell proliferation and partially ameliorated social impairments in frk−/− zebrafish. Overall, our work established an ASD model of frk-knockout with assessable behavior phenotype in zebrafish and provided key insights into cell proliferation and the influence of cyp24a1/tp53 pathway-regulated cell proliferation on frk-knockout-induced ASD-like behaviors.
Model-based Design of Reconfigurable Compliant Gripper Actuated with SMA Springs
Authors: Chen Qianyi , Duc Trung Tin Bui , Schott Dingena , Jovanova Jovana 
Published: January 2024

Abstract
Shape memory alloy (SMA) springs find extensive application in flexible actuation due to their significant capacity for deformability. However, each individual SMA spring only provides limited deformation modes, which prevents the SMA spring based grippers from applying in complicated grasping scenarios. In this study, a reconfigurable compliant gripper with multiple SMA springs is proposed to achieve multifunctional grasping tasks and large motion range. The proposed gripper uses multiple SMA springs for actuation, integrated in segments as building units to shape the gripper fingers. Also, the complete reconfigurable system was designed to accommodate for multiple compliant gripper fingers for flexibility. The reconfigurable compliant gripper is designed by numerical modeling and validated with lad-scaled experiments. The coupling method of Finite Element Analysis (FEA) and Multi Body Dynamics (MBD) was introduced in the modelling of the gripper. The results indicate that the numerical model shows very similar behavior as the experiments. Then, the multiple SMA spring allows for multidirectional bending behavior across the range of bending angle from 0 to 124 degrees. The reconfigurable compliant gripper system can grasp objects of different shapes and weights. Thus, the proposed reconfigurable compliant gripper can lead to a series of novel design solutions for different scales of grasping tasks.
The challenge of phasing out fossil fuel finance in the banking sector
Authors: Rickman Jamie , Falkenberg Max , Kothari Sumit , Larosa Francesca , Grubb Michael , Ameli Nadia 
Published: January 2024

Abstract

A rapid phase-out of bank lending to the fossil fuel sector is critical if Paris climate targets are to remain within reach. Here we use a systems lens to explore syndicated fossil fuel debt markets - a critical source of financing for fossil fuel companies - and find that they are resilient to uncoordinated and unregulated phase-out scenarios. In a setting where finance can be substituted between banks, phase-out is inefficient unless capital requirements rules limit banks’ exposure to fossil fuels. With capital requirements rules in place a tipping point is observed from inefficient to efficient phase-out as banks sequentially exit the sector. This tipping point depends critically on the stringency of capital requirements rules, and it is reached sooner in a targeted phase-out scenario where systemically important banks lead the phase-out. If sufficiently tightened, capital requirements rules can amplify the impact of individual banks’ phase-out and accelerate the decline of fossil fuel debt flows.
Inspiration4 Data Access through the NASA Open Science Data Repository
Authors: Costes Sylvain , Sanders Lauren , Grigorev Kirill , Scott Ryan , Saravia-Butler Amanda , Polo San-Huei Lai , Gilbert Rachel , Overbey Eliah , Kim JangKeun , Mason Christopher 
Published: January 2024

Abstract

The increasing accessibility of commercial and private space travel necessitates a profound understanding of its impact on human health. The NASA Open Science Data Repository (OSDR) provides transparent and FAIR access to biological studies, notably the SpaceX Inspiration4 (I4) mission, which amassed extensive data from civilian astronauts. This dataset encompasses omics and clinical assays, facilitating comprehensive research on space-induced biological responses. These data allow for multi-modal, longitudinal assessments, bridging the gap between human and model organism studies. Crucially, community-driven data standards established by NASA's OSDR Analysis Working Groups empower artificial intelligence and machine learning to glean invaluable insights, guiding future mission planning and health risk mitigation. This article presents a concise guide to access and analyze I4 data in OSDR, including programmatic access through GLOpenAPI. This pioneering effort establishes a precedent for post-mission health monitoring programs within space agencies, propelling research in the burgeoning field of commercial space travel's impact on human physiology.
Transplanting human infant gut microbiome species into Galleria mellonella
Authors: Gooch Harriet , Labedan Marjorie , Hall Lindsay , Maxwell Anthony 
Published: January 2024

Abstract

ObjectiveStudy of the human infant gut microbiome requires the use of surrogate mammalian species such as mice. We sought to investigate the usefulness of the greater wax moth larva, Galleria mellonella, as an alternative.
Results We have analysed the native gut microbiome of Galleria and developed methods for clearing the native microbiome and introducing species from human infant faecal samples. We find that some species, e.g. enterococci, are more successful at recolonisation, but that others, e.g. Bifidobacterium, are less so. The work paves the way for using Galleria rather than mice in this and similar work.