bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agribusiness Performance of Shallot Farm In Brebes Regency
Authors: Ekowati T. , Prasetyo E. , Mukson  
Published: October 2023

Abstract
In Brebes Regency, shallots are a promising product, however growers frequently experience unpredictable revenue and productivity. This has an impact on the performance of the agricultural sector by causing price fluctuations in shallot input and production. The goal of this study was to evaluate the shallot agribusiness system’s effectiveness in terms of agribusiness implementation, production-influencing factors, and financial profitability of the shallot farm. In this study, 60 shallot farmers from the districts of Brebes and Bulukamba participated in a survey. Regression analysis, shallot farm profitability, and study of the agribusiness implementation system are all used to analyze the data. The findings demonstrated that farmers had implemented shallot agribusiness with moderate to excellent criteria, and that the agribusiness application had an impact on shallot production. The average land tenure is 0.49 ha, with a 5,265 kg productivity that has room to grow. Land, seed, Ponska, ZA, SP36, pesticides, and the development of agribusiness are the elements that affect shallot production. The shallot farm’s production costs are IDR 26,723,592 and its income is IDR 40,931,650, meaning that the farm is 153.15% profitable. This demonstrates that the shallot agribusiness is a successful one. As a suggestion, farmers should continue to use agribusiness systems properly in order to boost shallot productivity and profitability.
Decomposition of matrix product states into shallow quantum circuits
Authors: Rudolph Manuel S , Chen Jing , Miller Jacob , Acharya Atithi , Perdomo-Ortiz Alejandro 
Published: October 2023

Abstract

Tensor networks (TNs) are a family of computational methods built on graph-structured factorizations of large tensors, which have long represented state-of-the-art methods for the approximate simulation of complex quantum systems on classical computers. The rapid pace of recent advancements in numerical computation, notably the rise of GPU and TPU hardware accelerators, have allowed TN algorithms to scale to even larger quantum simulation problems, and to be employed more broadly for solving machine learning tasks. The ‘quantum-inspired’ nature of TNs permits them to be mapped to parametrized quantum circuits (PQCs), a fact which has inspired recent proposals for enhancing the performance of TN algorithms using near-term quantum devices, as well as enabling joint quantum–classical training frameworks that benefit from the distinct strengths of TN and PQC models. However, the success of any such methods depends on efficient and accurate methods for approximating TN states using realistic quantum circuits, which remains an unresolved question. This work compares a range of novel and previously-developed algorithmic protocols for decomposing matrix product states (MPS) of arbitrary bond dimension into low-depth quantum circuits consisting of stacked linear layers of two-qubit unitaries. These protocols are formed from different combinations of a preexisting analytical decomposition method together with constrained optimization of circuit unitaries, with initialization by the former method helping to avoid poor-quality local minima in the latter optimization process. While all of these protocols have efficient classical runtimes, our experimental results reveal one particular protocol employing sequential growth and optimization of the quantum circuit to outperform all others, with even greater benefits in the setting of limited computational resources. Given these promising results, we expect our proposed decomposition protocol to form a useful ingredient within any joint application of TNs and PQCs, further unlocking the rich and complementary benefits of classical and quantum computation.
Pauli transfer matrix direct reconstruction: channel characterization without full process tomography
Authors: Roncallo Simone , Maccone Lorenzo , Macchiavello Chiara 
Published: October 2023

Abstract
We present a tomographic protocol for the characterization of multiqubit quantum channels. We discuss a specific class of input states, for which the set of Pauli measurements at the output of the channel directly relates to its Pauli transfer matrix components. We compare our results to those of standard quantum process tomography, showing an exponential reduction in the number of different experimental configurations required by a single matrix element extraction, while keeping the same number of shots. This paves the way for more efficient experimental implementations, whenever a selective knowledge of the Pauli transfer matrix is needed. We provide several examples and simulations.
Discussion on the impact of EU carbon border adjustment mechanism (CBAM) for China- EU trade
Authors: Yan Zhou , Yuan Zhao 
Published: October 2023

Abstract
To achieve the established carbon emission reduction targets, reduce the intensity of carbon leakage, and protect the EU local enterprise market, in December 2022, the amendment to the EU Carbon Border Adjustment Mechanism (CBAM), which covers key industries such as steel, aluminum products, cement, fertilizer, and electricity, was officially released by the EU Parliament decision and will be officially implemented on October 1, 2023. This study tries to discuss its impact for China—EU trade.
A Cluster-Randomized Evaluation of the SuperShelf Intervention in Choice-Based Food Pantries
Authors: Caspi Caitlin E , Gombi-Vaca Maria F , Barsness Christina Bliss , Gordon Nora , Canterbury Marna , Peterson Hikaru Hanawa , Wolfson Julian , Pratt Rebekah 
Published: October 2023

Abstract

Background
Interventions in food pantry settings have the potential to improve health among clients at risk of diet-related disease.

Purpose
This study evaluates whether a cluster-randomized, behavioral intervention in food pantries resulted in improved client outcomes.

Methods
Sixteen Minnesota food pantries were randomized to an intervention (n = 8) or control condition (n = 8). The intervention offered pantries technical assistance to improve healthy food supply and implement behavioral economics strategies to promote healthy food selection. A convenience sample of adult clients were enrolled (paired sample, 158 intervention, 159 control) and followed for 1 year. Additional clients were enrolled at follow-up to assess food selection (follow-up sample, 85 intervention, 102 control). Analysis was limited to data from 11 pantries (5 intervention, 6 control) due to COVID-19. Outcome measures included Healthy Eating Index-2015 (HEI-2015) total and subcomponent scores for 24-hr dietary recalls and client cart selections, and Life’s Simple 7 (LS7) total and subcomponent scores. Multilevel mixed-effects models tested whether client outcomes differed by intervention condition.

Results
In adjusted models, there were no statistically significant differences by intervention condition in HEI-2015 or LS7 scores. Clients in intervention food pantries had improved Refined Grain subcomponent scores (p = .004); clients in control pantries had worsened Saturated Fat subcomponents scores (p = .019) and improved physical activity scores (p = .007).

Conclusions
The intervention did not result in improved diet quality or cardiovascular health as measured by HEI-2015 or LS7. Coordinated efforts across settings are needed to address health risks facing this population.
‘Raisin bread sign’ feature of pontine autosomal dominant microangiopathy and leukoencephalopathy
Authors: Kikumoto Mai , Kurashige Takashi , Ohshita Tomohiko , Kume Kodai , Kikumoto Osamu , Nezu Tomohisa , Aoki Shiro , Ochi Kazuhide , Morino Hiroyuki , Nomura Eiichi , Yamashita Hiroshi , Kaneko Mayumi , Maruyama Hirofumi , Kawakami Hideshi 
Published: October 2023

Abstract
Pontine autosomal dominant microangiopathy and leukoencephalopathy is one of hereditary cerebral small vessel diseases caused by pathogenic variants in COL4A1 3′UTR and characterized by multiple small infarctions in the pons. We attempted to establish radiological features of this disease. We performed whole exome sequencing and Sanger sequencing in one family with undetermined familial small vessel disease, followed by clinicoradiological assessment and a postmortem examination. We subsequently investigated clinicoradiological features of patients in a juvenile cerebral vessel disease cohort and searched for radiological features similar to those found in the aforementioned family. Sanger sequencing was performed in selected cohort patients in order to detect variants in the same gene. An identical variant in the COL4A1 3′UTR was observed in two patients with familial small vessel disease and the two selected patients, thereby confirming the pontine autosomal dominant microangiopathy and leukoencephalopathy diagnosis. Furthermore, postmortem examination showed that the distribution of thickened media tunica and hyalinized vessels was different from that in lacunar infarctions. The appearance of characteristic multiple oval small infarctions in the pons, which resemble raisin bread, enable us to make a diagnosis of pontine autosomal dominant microangiopathy and leukoencephalopathy. This feature, for which we coined the name ‘raisin bread sign’, was also correlated to the pathological changes.
Janus Kinase Inhibitors Differentially Inhibit Specific Cytokine Signals in the Mesenteric Lymph Node Cells of Inflammatory Bowel Disease Patients
Authors: Hindmarch Duncan C , Malashanka Sofya , Shows Donna M , Clarke Astrid S , Lord James D 
Published: October 2023

Abstract

Background
Janus kinase [JAK] inhibitors [JAKinibs] are effective small molecule therapies for treating Crohn’s disease [CD] and ulcerative colitis [UC], collectively known as inflammatory bowel disease [IBD]. By preventing JAKs from phosphorylating signal transducer and activator of transcription proteins, JAKinibs disrupt cytokine signalling pathways that promote inflammation. Despite considerable overlap in the JAKs they target, first- and second-generation JAKinibs display different clinical efficacies in CD and UC.

Methods
We conducted a comparative phosflow study of four JAKinibs [filgotinib, upadacitinib, tofacitinib, and deucravacitinib] to observe subtle mechanistic differences that may dictate their clinical behaviour. Resected mesenteric lymph node [MLN] cells from 19 patients [9 CD, 10 UC] were analysed by flow cytometry in the presence or absence of different cytokine stimuli and titrated JAKinibs.

Results
We found a higher potency of the JAK 1/3-preferential inhibitor, tofacitinib, for JAK 3-dependent cytokine signalling pathways in comparison to filgotinib, but a higher potency of the JAK 1-preferential inhibitors, filgotinib and upadacitinib, for JAK 3-independent cytokine signalling pathways. Deucravacitinib, a TYK2-preferential inhibitor, demonstrated a much narrower selectivity by inhibiting only IL-10 and IFN-β pathways, albeit more potently than the other JAKinibs. Additionally, we found some differences in the sensitivity of immune cells from CD versus UC, and patients with versus without a CD-associated NOD2 polymorphism, to phosphorylate signal transducer and activator of transcriptions in response to specific cytokine stimulation.

Conclusions
Despite their similarities, differences exist in the relative potencies of different JAKinibs against distinct cytokine families, to explain their clinical efficacy.
Evolocumab in paediatric heterozygous familial hypercholesterolaemia: cognitive function during 80 weeks of open-label extension treatment
Authors: Santos Raul D , Ruzza Andrea , Wang Bei , Maruff Paul , Schembri Adrian , Bhatia Ajay K , Mach François , Bergeron Jean , Gaudet Isabelle , St Pierre Julie , Kastelein John J P , Hovingh G Kees , Wiegman Albert , Gaudet Daniel , Raal Frederick J 
Published: October 2023

Abstract

Aims
PCSK9 inhibition intensively lowers low density lipoprotein cholesterol and is well tolerated in adults and paediatric patients with familial hypercholesterolaemia (FH). HAUSER-RCT showed that 24 weeks of treatment with evolocumab in paediatric patients did not affect cognitive function. This study determined the effects of 80 additional weeks of evolocumab treatment on cognitive function in paediatric patients with heterozygous FH.

Methods and results
HAUSER-OLE was an 80-week open-label extension of HAUSER-RCT, a randomized, double-blind, 24-week trial evaluating the efficacy and safety of evolocumab in paediatric patients (ages 10–17 years) with FH. During the OLE, all patients received monthly 420 mg subcutaneous evolocumab injections. Tests of psychomotor function, attention, visual learning, and executive function were administered at baseline and Weeks 24 and 80 of the OLE. Changes over time were analysed descriptively and using analysis of covariance. Cohen’s d statistic was used to evaluate the magnitude of treatment effects. Analysis of covariance results indicated no decrease in performance across visits during 80 weeks of evolocumab treatment for Groton Maze Learning, One Card Learning accuracy, Identification speed, or Detection speed (all P &gt; 0.05). Performance on all tasks was similar for those who received placebo or evolocumab in the RCT (all P &gt; 0.05). For all tests, the least square mean differences between patients who received placebo vs. evolocumab in the parent study were trivial (all Cohen’s d magnitude &lt; 0.2).

Conclusion
In paediatric patients with FH, 80 weeks of open-label evolocumab treatment had no negative impact on cognitive function.

Registration
ClinicalTrials.gov identifier: NCT02624869
Fungal drops: a novel approach for macro- and microscopic analyses of fungal mycelial growth
Authors: Buffi Matteo , Cailleau Guillaume , Kuhn Thierry , Li Richter Xiang-Yi , Stanley Claire E , Wick Lukas Y , Chain Patrick S , Bindschedler Saskia , Junier Pilar 
Published: October 2023

Abstract
This study presents an inexpensive approach for the macro- and microscopic observation of fungal mycelial growth. The ‘fungal drops’ method allows to investigate the development of a mycelial network in filamentous microorganisms at the colony and hyphal scales. A heterogeneous environment is created by depositing 15–20 µl drops on a hydrophobic surface at a fixed distance. This system is akin to a two-dimensional (2D) soil-like structure in which aqueous-pockets are intermixed with air-filled pores. The fungus (spores or mycelia) is inoculated into one of the drops, from which hyphal growth and exploration take place. Hyphal structures are assessed at different scales using stereoscopic and microscopic imaging. The former allows to evaluate the local response of regions within the colony (modular behaviour), while the latter can be used for fractal dimension analyses to describe the hyphal network architecture. The method was tested with several species to underpin the transferability to multiple species. In addition, two sets of experiments were carried out to demonstrate its use in fungal biology. First, mycelial reorganization of Fusarium oxysporum was assessed as a response to patches containing different nutrient concentrations. Second, the effect of interactions with the soil bacterium Pseudomonas putida on habitat colonization by the same fungus was assessed. This method appeared as fast and accessible, allowed for a high level of replication, and complements more complex experimental platforms. Coupled with image analysis, the fungal drops method provides new insights into the study of fungal modularity both macroscopically and at a single-hypha level.
Transcription factors involved in tomato fruit quality improvement
Authors: Shi Yanna , Dai Zhengrong , Chen Kunsong 
Published: October 2023

Abstract
Fruit quality is both a consumer demand and an important goal for horticultural breeding. The exploration of quality-related genes provides targets to create high-quality germplasm using biotechnology, of which transcription factors (TFs) exhibit dosage effects compared with structural genes. Tomato, an important horticultural crop as well as model fruit, has been widely studied. Here, we focused on TFs with potential utilization value that control appearance (e.g. shape, pigment) and internal (e.g. flavor, texture, shelf life and health benefits) quality in tomato. Additionally, potential strategies to generate high-quality tomato fruit are discussed.
Long-term follow-up of endoscopic papillectomy and the value of preventive pancreatic stent placement (with videos)
Authors: Wang Yuling , Zhang Xiaoqing , Yang Zhenhua , Wang Teng , Zhu Dongqing , Gao Jie , Zhang Ping-Ping , Wang Peiqin , Shi Xingang 
Published: October 2023

Abstract

Background
Early-stage ampullary adenomas have only been reported in a small case series on endoscopic management. Hence, this study aimed to evaluate the long-term outcomes of early ampullary adenoma with endoscopic management and identify the risk factors for acute pancreatitis after endoscopic papillectomy (EP).

Methods
In this study, 115 patients who underwent EP at Changhai Hospital (Shanghai, China) between January 2012 and December 2018 were retrospectively analysed. Endoscopy was performed at 1, 3, 6, and 12 months after EP. Data were statistically analysed using the t-test or the Mann–Whitney U test.

Results
A total of 107 patients were included in this study and the follow-up period was 75 ± 43 months. The average age of the 107 patients was 54.6 years and the average tumor size was 17 mm. The average age of the patients (53.7 ± 10.7 years vs 55.2 ± 10.5 years, P = 0.482), minimum tumor size (13 vs 19 mm, P = 0.063), and complete resection rate (84.78% vs 85.25%, P = 0.947) did not differ significantly between the stent placement and non-stent placement groups. Post-EP acute pancreatitis rates in the non-stent placement and stent placement groups were 11.48% and 4.35%, respectively. The risk of post-EP acute pancreatitis was significantly associated with the preoperative carcinoembryonic antigen level in univariate analysis, but not in multivariate analysis. The risk of post-EP acute pancreatitis was not significantly associated with the placement of the pancreatic stent in either univariate or multivariate analysis. Moreover, delayed proximal pancreatic duct stenosis was not noted in either group during long-term follow-up.

Conclusions
EP is a satisfactory option for treating adenomas of the ampulla of the duodenum.
Three-component high-resolution seismic time–frequency polarization filter
Authors: Kazemnia Kakhki Mohsen , Mokhtari Ahmadreza , Mansur Webe João , Del Gaudio Vincenzo 
Published: October 2023

SUMMARY
The analysis of earthquake recordings from three-component instruments can be challenging due to overlapping events. Time–frequency (TF) polarization methods are efficient tools for this purpose, which can discriminate these events. Previous polarization methods did not consider all three components simultaneously while transferring data to TF domain, which can cause inaccuracies in the reconstruction of wave amplitudes. Therefore, the three-component sparse adaptive S transform (3C-SAST) algorithm is preferred to other TF decompositions since it is mainly developed for polarization analysis purposes, and outperforms other TF methods. In this paper, we developed the 3C-SAST by adding a parameter to adjust the sparseness of the solution and make the resolution flexible. The developed TF decomposition is then used to extend the Morozov & Smithson method to TF domain, and devise a new TF polarization filter whose invertibility and resolution flexibility make it a promising tool for wavefield separation. This filter can eliminate the out-of-plane arrival energies and extract the Rayleigh waves for multicomponent data, which has application in Rayleigh wave tomography and seismological studies. We demonstrated the efficiency of the proposed method for seismic surface waves separation using synthetic signals and three-component teleseismic earthquake recording.
LSC-GInSAR: a GNSS-enhanced InSAR approach by using least squares collocation
Authors: Chen Hailu , Shen Yunzhong 
Published: October 2023

SUMMARY
High quality Interferometric Synthetic Aperture Radar (InSAR) interferograms are essential for determining surface deformation from InSAR time-series. However, InSAR interferograms are usually polluted by spatially correlated errors (SCEs), especially the unmodelled atmospheric phase delays. To mitigate spatially correlated errors and improve the quality of InSAR interferograms, we propose a new approach to incorporate the Global Navigation Satellite System (GNSS) data from continuously operating reference stations for enhancing InSAR interferograms via modelling SCEs as signals and solving the signals together with the systematic parameters using least squares collocation (LSC), which is referred to as the LSC-GInSAR approach. Our improvement for the GInSAR method of Neely et al. can correct more SCEs. The Sentinel-1 data over the southern Central Valley of California, USA, are processed with our LSC-GInSAR approach, which is compared to the GInSAR approach. The performance of the LSC-GInSAR approach is evaluated by external GNSS displacements. The results show that the LSC-GInSAR approach can effectively mitigate medium-to-long-wavelength SCEs. The displacements resolved by LSC-GInSAR are more consistent with the cGNSS observations than those resolved by GInSAR, with an average root mean square improvement of 14.3 per cent. In addition, the LSC-GInSAR approach reduced the average standard deviations of all 276 InSAR interferograms from 14.2 to 11.0 mm compared to that of the GInSAR approach.
The telomere-to-telomere gap-free reference genome of wild blueberry (Vaccinium duclouxii) provides its high soluble sugar and anthocyanin accumulation
Authors: Zeng Tuo , He Zhijiao , He Jiefang , Lv Wei , Huang Shixiang , Li Jiawen , Zhu Liyong , Wan Shuang , Zhou Wanfei , Yang Zhengsong , Zhang Yatao , Luo Chong , He Jiawei , Wang Caiyun , Wang Liangsheng 
Published: October 2023

Abstract
Vaccinium duclouxii, endemic to southwestern China, is a berry-producing shrub or small tree belonging to the Ericaceae family, with high nutritive, medicinal, and ornamental value, abundant germplasm resources, and good edible properties. In addition, V. duclouxii exhibits strong tolerance to adverse environmental conditions, making it a promising candidate for research and offering wide-ranging possibilities for utilization. However, the lack of V. duclouxii genome sequence has hampered its development and utilization. Here, a high-quality telomere-to-telomere genome sequence of V. duclouxii was de novo assembled and annotated. All of 12 chromosomes were assembled into gap-free single contigs, providing the highest integrity and quality assembly reported so far for blueberry. The V. duclouxii genome is 573.67 Mb, which encodes 41 953 protein-coding genes. Combining transcriptomics and metabolomics analyses, we have uncovered the molecular mechanisms involved in sugar and acid accumulation and anthocyanin biosynthesis in V. duclouxii. This provides essential molecular information for further research on the quality of V. duclouxii. Moreover, the high-quality telomere-to-telomere assembly of the V. duclouxii genome will provide insights into the genomic evolution of Vaccinium and support advancements in blueberry genetics and molecular breeding.