bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humble leadership and work–family enrichment: promotion focused and thriving
Authors: Huang Yong , Zhang Yancui , Cui Min , Peng Xin 
Published: February 2024

PurposeDrawing upon work-home resources model, this study aims to investigate how and when humble leadership influences followers’ work–family enrichment. Specifically, this study focuses on the mediating role of thriving at work and moderating role of promotion focus.Design/methodology/approachData were collected from 292 employees of science and technology enterprises in China through a three-wave questionnaire survey. Hierarchical regression analysis and bootstrapping approach were employed to test hypotheses.FindingsThis study found that thriving at work significantly mediated the relationship between humble leadership and work–family enrichment. Promotion focus strengthened the positive relationship between humble leadership and thriving at work and the indirect effect of humble leadership on work–family enrichment through thriving at work.Practical implicationsThe findings of this study offer guidance for managers to enhance thriving at work and improve employees’ work–family experiences.Originality/valueFirst, this study explores the work-to family spillover effects of humble leadership by examining the family outcomes of humble leadership. Second, this study further uncovers the underlying mechanism between humble leadership and work–family enrichment by demonstrating the mediating role of thriving at work. Third, by exploring the moderating role of promotion focus, this study provides insight into the boundary conditions of the impact of humble leadership.
Gaillardin exerts potent antileukemic effects on HL‐60 cells and intensifies arsenic trioxide cytotoxicity: Providing new insight into sesquiterpene lactones in leukaemia treatment
Authors: Noormohamadi Hanieh , Hamzeloo‐Moghadam Maryam , Bashash Davood , Kargar Maryam , Izadirad Mehrdad , Hasanpour Seyedeh Zahra , Gharehbaghian Ahmad 
Published: February 2024

AbstractThe use of all‐trans retinoic acid and arsenic trioxide resulted in favourable therapeutic responses in standard‐risk acute promyelocytic leukaemia (APL) patients. However, resistance to these agents has made treating the high‐risk subgroup more problematic, and possible side effects limit their clinical dosages. Numerous studies have proven the cytotoxic properties of Gaillardin, one of the Inula oculus‐christi‐derived sesquiterpene lactones. Due to the adverse effects of arsenic trioxide on the high‐risk subgroup of APL patients, we aimed to assess the cytotoxic effect of Gaillardin on HL‐60 cells as a single or combined‐form approach. The results of the trypan blue and MTT assays outlined the potent cytotoxic properties of Gaillardin. The flow cytometric analysis and the mRNA expression levels revealed that Gaillardin attenuated the proliferative capacity of HL‐60 cells through cell cycle arrest and induced apoptosis via reactive oxygen species generation. Moreover, the results of synergistic experiments indicated that this sesquiterpene lactone sensitizes HL‐60 cells to the cytotoxic effects of arsenic trioxide. Taken together, the findings of the present investigation highlighted the antileukemic characteristics of Gaillardin by inducing G1 cell cycle arrest and triggering apoptosis. Gaillardin acts as an antileukemic metabolite against HL‐60 cells and this study provides new insight into treating APL patients, especially in the high‐risk subgroup.
A Semantically Rich ‘Do’‐Support Verb in the Camuno Dialect of Northern Italy
Authors: Swinburne Nicola 
Published: February 2024

AbstractIn the Camuno dialect of northern Italy, ‘do’‐support may be used to form the interrogative. In some varieties, this is optional, and it co‐exists with the alternative interrogative method of using the main verb alone. Through an elicitation experiment, participants produced their preferred version of a question based on a certain main verb with given context. The likelihood that ‘do’‐support was used varied according to the supported verb's semantics and the context pragmatics, specifically: (a) the degree to which the verb denotes activity (directly or indirectly); and (b) the role of the subject as an effector, or ‘do’‐er of that activity. Unlike for ‘do’‐support in English, a purely syntactic function does not seem relevant for Camuno ‘do’. The study shows that: (1) even if, syntactically, the support verb resembles an auxiliary, it may have full lexical content; and (2) that there exists a credible grammaticalisation pathway from a lexical ‘do’ verb to a semantically bleached, contentless ‘do’, seemingly motivated by a social preference for the ‘do’‐support construction and a desire to simplify the interrogative system.
Probiotic‐fermented edible herbs as functional foods: A review of current status, challenges, and strategies
Authors: Cui Rui , Zhang Cong , Pan Zhen‐Hui , Hu Teng‐Gen , Wu Hong 
Published: February 2024

AbstractRecently, consumers have become increasingly interested in natural, health‐promoting, and chronic disease‐preventing medicine and food homology (MFH). There has been accumulating evidence that many herbal medicines, including MFH, are biologically active due to their biotransformation through the intestinal microbiota. The emphasis of scientific investigation has moved from the functionally active role of MFH to the more subtle role of biotransformation of the active ingredients in probiotic‐fermented MFH and their health benefits. This review provides an overview of the current status of research on probiotic‐fermented MFH. Probiotics degrade toxins and anti‐nutritional factors in MFH, improve the flavor of MFH, and increase its bioactive components through their transformative effects. Moreover, MFH can provide a material base for the growth of probiotics and promote the production of their metabolites. In addition, the health benefits of probiotic‐fermented MFH in recent years, including antimicrobial, antioxidant, anti‐inflammatory, anti‐neurodegenerative, skin‐protective, and gut microbiome‐modulating effects, are summarized, and the health risks associated with them are also described. Finally, the future development of probiotic‐fermented MFH is prospected in combination with modern development technologies, such as high‐throughput screening technology, synthetic biology technology, and database construction technology. Overall, probiotic‐fermented MFH has the potential to be used in functional food for preventing and improving people's health. In the future, personalized functional foods can be expected based on synthetic biology technology and a database on the functional role of probiotic‐fermented MFH.
Cell counting to monitor swab efficiency
Authors: Nolan Madison , Linacre Adrian 
Published: February 2024

AbstractPlastic bags, such as ziplock bags, have been used to transport illicit materials worldwide; however, very few studies have tried to optimize the recovery of DNA from these items. This study reports on the best combination of swabs and moistening solution for the greatest recovery of cellular material from ziplock bags. Five swabs, two different variations of Copan Diagnostics nylon 4N6FLOQSwabs, one Medical Wire rayon DRYSWAB, one IsoHelix rayon swab, and one Livingstone cotton swab, were evaluated with two moistening solutions, Triton X‐100 in either distilled water or isopropanol. Fingermarks were deposited on ziplock bags and stained with Diamond™ Nucleic Acid Dye to allow visualization of the cells pre‐ and post‐swabbing to determine the number of cells recovered. Based on cell counting data, swabs moistened with Triton X‐100 in distilled water performed better than those moistened with isopropanol. Livingstone cotton swabs had the worst recovery of cellular material, while the other swabs tested had no significant difference in their respective solutions. A comparison of the best three swabs for cellular recovery yielded no differences in the DNA concentration extracted. A linear relationship was observed between the log number of cells recovered by swabbing and the DNA concentration following extraction and quantification. The process of monitoring cell collection using fluorescence microscopy on ziplock bags allowed evaluation of swabbing efficacy. Additionally, this study highlights the ability to evaluate cellular recovery independently of traditional extraction, quantification, or profiling techniques which may unequally affect samples.
MicroRNA response to temperature stress in the wolf spider Pardosa pseudoannulata (Araneae: Lycosidae)
Authors: Zhang Haoran , Wang Zonglin , Song Yilan , Zhang Fanxue , Wen Lelei , Xiao Rong , Jin Daochao 
Published: February 2024

AbstractMicroRNAs (miRNAs) are conserved noncoding small RNAs that play essential regulatory roles in gene function by regulating target genes. Pardosa pseudoannulata is an important natural predatory enemy of insect pests and plays a significant role in controlling pests in rice fields, with temperature having a significant impact on their growth and development. To understand the response of miRNAs to temperature stress in P. pseudoannulata, we performed miRNA identification analyses of adult spiders exposed to 10°C and 40°C for 12 h, as low‐temperature and high‐temperature treatment groups, respectively. We obtained 54.74 M clean reads from 69.84 M raw reads after filtering out low‐quality reads, and 78 miRNAs including 13 novel miRNAs were identified from three small RNA libraries (10°C, 25°C and 40°C). At the low temperature and the high temperature, eight (one upregulated and seven downregulated) and ten (nine upregulated and one downregulated) differentially expressed miRNAs were identified, respectively. These differentially expressed miRNAs negatively regulated 43 and 12 target mRNA (the unigenes in our previous transcriptome sequence data) in response to low‐ and high‐temperature stress, respectively. These target genes are mainly involved in translation, ribosome structure and biotransformation, as well as the generation and conversion of energy. This study represents the first report of miRNA identification related to the Araneae spider species in response to temperature stress. These results will greatly facilitate our understanding of the physiological and biochemical mechanisms of spiders in response to temperature stress, which might be beneficial for the conservation and utilization of this species as an important natural insect enemy of pests in rice ecosystems.
Assessment of freeze, continuous, and intermittent infrared drying methods for sliced persimmon
Authors: Polat Ahmet , Taskin Onur , Izli Nazmi 
Published: February 2024

AbstractPersimmons contribute positively to human health. Although off‐season utilization typically presents a challenge due to permissions’ perishable nature, it may become feasible through the implementation of appropriate drying methods. In this study, round sliced samples were dried to assess drying kinetics, modeling potential, color attributes, rehydration capacity, energy consumption (EC), cost index, and thermal properties. The fruits were subjected to distinct drying methodologies including freeze‐drying, continuous infrared drying (300, 400, and 500 W), and intermittent infrared drying (PR = 1 [continuous], PR = 2 [30 s on–30 s off], and PR = 3 [20 s on–40 s off]). The duration of the drying process ranged from 40 to 390 min. It was determined that the most suitable models for depicting continuous and infrared drying kinetics of persimmon fruit were the Midilli et al. and Page models, whereas the Logarithmic model was identified as the optimal choice for characterization of freeze‐drying kinetics. Assessment of EC revealed that both intermittent and continuous infrared drying methods incurred lower energy expenditure in comparison to the freeze‐drying technique. Remarkably, throughout the course of the infrared drying processes, product surface temperatures varied between 106.33 and 22.65°C across different treatments. Despite its high EC, it has been found that high‐quality products are produced by freeze‐drying. However, infrared and intermittent infrared applications can be a low energy cost and feasible method for drying persimmon with a shorter duration.Practical ApplicationPersimmon is an important fruit with high nutritional value. However, as with many fresh products, they have a short shelf life. Within the scope of this research, three different drying methodologies were employed in the desiccation of persimmon specimens, and the impact of these methodologies on the overall qualitative attributes of the persimmon product was investigated. Despite its elevated energy consumption, the freeze‐drying approach was found to yield high‐quality products. Moreover, it was discerned that infrared drying represented a viable and expeditious alternative for drying the fruit, particularly when executed intermittently.
Adenovirus pneumonia mimicking osimertinib‐induced pneumonitis in a patient with advanced NSCLC with EGFR mutation: A case report
Authors: Imai Toru , Yoshida Tatsuya , Ohe Yuichiro 
Published: February 2024

AbstractDrug‐related pneumonitis (DRP) caused by epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors (TKIs) is a fatal adverse event in patients with EGFR‐mutant non‐small cell lung cancer (NSCLC). The diagnosis of DRP is based on radiological findings, the temporal association of presentation with the initiation of a systemic therapeutic agent, and the exclusion of other likely causes. Here we report a case in which severe adenoviral pneumonia mimicking DRP occurred during treatment with osimertinib, and osimertinib was successfully resumed after recovery from adenoviral pneumonia.
N‐homocysteinylation of DJ‐1 promotes neurodegeneration in Parkinson's disease
Authors: Guo Tao , Zhou Lingyan , Xiong Min , Xiong Jing , Huang Juan , Li Yiming , Zhang Guoxin , Chen Guiqin , Wang Zhi‐Hao , Xiao Tingting , Hu Dan , Bao Anyu , Zhang Zhentao 
Published: February 2024

AbstractDJ‐1, also known as Parkinson's disease protein 7 (Park7), is a multifunctional protein that regulates oxidative stress and mitochondrial function. Dysfunction of DJ‐1 is implicated in the pathogenesis of Parkinson's disease (PD). Hyperhomocysteinemia is associated with an increased risk of PD. Here we show that homocysteine thiolactone (HTL), a reactive thioester of homocysteine (Hcy), covalently modifies DJ‐1 on the lysine 182 (K182) residue in an age‐dependent manner. The N‐homocysteinylation (N‐hcy) of DJ‐1 abolishes its neuroprotective effect against oxidative stress and mitochondrial dysfunction, exacerbating cell toxicity. Blocking the N‐hcy of DJ‐1 restores its protective effect. These results indicate that the N‐hcy of DJ‐1 abolishes its neuroprotective effect and promotes the progression of PD. Inhibiting the N‐hcy of DJ‐1 may exert neuroprotective effect against PD.
Sex differences in alcohol's effects on fronto‐amygdalar functional connectivity during processing of emotional stimuli
Authors: McKenna Benjamin S. , Anthenelli Robert M. , Schuckit Marc A. 
Published: February 2024

AbstractBackgroundAmygdala function underlying emotion processing has been shown to vary with an individuals' biological sex. Expanding upon functional magnetic resonance imaging (fMRI) findings reported previously where a low level of response was the focus, we examined alcohol and sex effects on functional connectivity between the amygdala and other brain regions. The central hypothesis predicted that sex would influence alcohol's effects on frontal‐limbic functional circuits underlying the processing of negative and positive facial emotions.MethodsSecondary analyses were conducted on data from a double‐blind, placebo controlled, within‐subjects, cross‐over study in 54 sex‐matched pairs (N = 108) of 18‐ to 25‐year‐old individuals without an alcohol use disorder at baseline. Participants performed an emotional faces fMRI processing task after placebo or approximately 0.7 mL/kg of ethanol. Psychophysiological interaction analyses examined functional connectivity between the amygdala with other brain regions.ResultsThere were significant alcohol‐by‐sex interactions when processing negatively valenced faces. Whereas intoxicated men exhibited decreased functional connectivity between the amygdala and ventral and dorsal anterior cingulate, angular gyrus, and middle frontal gyrus connectivity was increased in intoxicated women. There was also a main sex effect where women exhibited less functional connectivity in the middle insula than men regardless of whether they received alcohol or placebo. For happy faces, main effects of both sex and alcohol were observed. Women exhibited less amygdala functional connectivity in the right inferior frontal gyrus than men. Both men and women exhibited greater functional connectivity in the superior frontal gyrus in response to alcohol than placebo.ConclusionsAlcohol's effects on amygdala functional circuits that underlying emotional processing vary by sex. Women had higher functional connectivity than men following exposure to a moderate dose of alcohol which could indicate that women are better than men at processing affectively laden stimuli when intoxicated.
Testing the effectiveness of lottery incentives in online experiments
Authors: Ahles Amelia , Palma Marco A. , Drichoutis Andreas C. 
Published: February 2024

AbstractThis article investigates the effectiveness of lottery incentive schemes for eliciting consumer valuations in large‐scale online experiments. We implement a fully incentivized condition within a geographically dispersed sample of consumers in which bids for a Criollo steak elicited by a Becker‐DeGroot‐Marschak mechanism are realized with certainty and the products are priority shipped in dry‐ice coolers. The fully incentivized condition is compared to between‐subject random incentivized schemes, in which only a fraction of subjects realize their choices. We tested two treatments with a 10% probability framed as a percentage or an absolute number of subjects, one treatment with a 1% probability, and a purely hypothetical reference condition. The results reveal that between‐subject random incentivized schemes with 10% and 1% payment probabilities are effective in eliciting valuations that are statistically indistinguishable from the fully incentivized scheme. In addition to finding insignificant statistical differences between 10% and 1% and the fully incentivized scheme, all incentivized conditions mitigate hypothetical bias, resulting in lower product valuations than the purely hypothetical condition. We contribute a novel methodological framework for conducting large‐scale experiments with geographically diverse and representative subjects, increasing the external validity and producing reliable valuations while significantly reducing financial and logistic constraints.
Mockery amid shooting: Laughter as an expression of expertise at a public clinic in Greater Rio de Janeiro, Brazil
Authors: Lima Pedro Silva Rocha 
Published: February 2024

AbstractLaughter is one of the “weapons of the weak,” a means of degrading those in a position of power. Seeing laughter as such, however, only offers a view into what the performance does to its target, by belittling it, without saying much about what it does to the performer within a given power relation. This article investigates the potential of mockery and laughter to become expressions of expertise when they establish the performer as a knowing subject in relation to their target. Based on fieldwork conducted at a public clinic in Duque de Caxias, Brazil, this article analyzes how locally resident staff, through their extended work and dwelling in a neighborhood where shootings are frequent, mocked their superiors who did not know how to appropriately assess and react to the sound of shooting. By establishing the performer as the knowing subject in relation to those being mocked, laughter in this setting had the potential to unsettle classed hierarchies of knowledge.
Transketolase drives the development of aortic dissection by impairing mitochondrial bioenergetics
Authors: Wang Chaoyun , Zhang Li , Zhang Qinghua , Zheng Hui , Yang Xi , Cai Weixing , Zou Qiuying , Lin Jingjing , Zhang Lin , Zhong Lin , Li Xinyao , Liao Yuqing , Liu Qin , Chen Liangwan , Li Yumei 
Published: February 2024

AbstractAimAortic dissection (AD) is a disease with rapid onset but with no effective therapeutic drugs yet. Previous studies have suggested that glucose metabolism plays a critical role in the progression of AD. Transketolase (TKT) is an essential bridge between glycolysis and the pentose phosphate pathway. However, its role in the development of AD has not yet been elucidated. In this study, we aimed to explore the role of TKT in AD.MethodsWe collected AD patients' aortic tissues and used high‐throughput proteome sequencing to analyze the main factors influencing AD development. We generated an AD model using BAPN in combination with angiotensin II (Ang II) and pharmacological inhibitors to reduce TKT expression. The effects of TKT and its downstream mediators on AD were elucidated using human aortic vascular smooth muscle cells (HAVSMCs).ResultsWe found that glucose metabolism plays an important role in the development of AD and that TKT is upregulated in patients with AD. Western blot and immunohistochemistry confirmed that TKT expression was upregulated in mice with AD. Reduced TKT expression attenuated AD incidence and mortality, maintained the structural integrity of the aorta, aligned elastic fibers, and reduced collagen deposition. Mechanistically, TKT was positively associated with impaired mitochondrial bioenergetics by upregulating AKT/MDM2 expression, ultimately contributing to NDUFS1 downregulation.ConclusionOur results provide new insights into the role of TKT in mitochondrial bioenergetics and AD progression. These findings provide new intervention options for the treatment of AD.
Comparison of urological outcomes and quality of life after pelvic exenteration: partial vs radical cystectomy
Authors: van Kessel Charlotte S. , Palma Catalina A. , Solomon Michael J. , Leslie Scott , Jeffery Nicola , Lee Peter J. , Austin Kirk K. S. 
Published: February 2024

ObjectiveTo compare perioperative morbidity, functional and quality‐of‐life (QoL) outcomes in patients with partial cystectomy vs radical cystectomy as part of pelvic exenteration.Patients and MethodsRetrospective analysis of a prospectively maintained database of pelvic exenteration patients (1998–2021) was conducted in a single centre. Study outcomes included postoperative complications, quality‐of‐life, functional and stoma‐related outcomes. The 36‐item Short‐Form Health Survey Physical and Mental Health Components, Functional Assessment of Cancer Therapy‐Colorectal questionnaires and Distress Thermometer were available pre‐ and postoperatively. QoL outcomes were compared at the various time points. Stoma embarrassment and care scores were compared between patients with a colostomy, urostomy, and both.ResultsUrological complications were similar between both groups, but patients with partial cystectomy experienced less wound‐related complications. Overall, 34/81 (42%) partial cystectomy patients reported one or more long‐term voiding complication (i.e., incontinence [17 patients], frequency [six], retention [three], high post‐voiding residuals [10], permanent suprapubic catheter/indwelling catheter [14], recurrent urinary tract infection [nine], percutaneous nephrostomy [three], progression to urostomy [three]). The QoL improved following surgery in both the partial and radical cystectomy groups, differences between cohorts were not significant. Patients with two stomas reported higher embarrassment scores than patients with one stoma, although this did not result in more difficulties in stoma care.ConclusionsPartial cystectomy patients have fewer postoperative wound‐related complications than radical cystectomy patients, but often experience long‐term voiding issues. The QoL outcomes are similar for both cohorts, with significant improvement following surgery.