bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular disease risk models and dementia or cognitive decline: a systematic review
Authors: Jia Ruirui , Wang Qing , Huang Hengyi , Yang Yanli , Chung Yuet Foon , Liang Tao 
Published: October 2023

BackgroundHealth cognitive promotion and protection is a critical topic. With the world’s aging population and rising life expectancy, there will be many people living with highly age-related dementia illnesses. Cardiovascular disease (CVD) and dementia share the same risk factors, such as unhealthy lifestyles and metabolic factors. These recognized risks associated with CVD and dementia frequently co-occur. CVD risk models may have a close association with dementia and cognitive decline. So, this systematic review aimed to determine whether CVD risk models were connected with dementia or cognitive decline and compare the predictive ability of various models.MethodsPubMed, Web of Science, PsychINFO, Embase, Cochrane Library, CNKI, Sinomed, and WanFang were searched from 1 January 2014 until 16 February 2023. Only CVD risk models were included. We used the Newcastle-Ottawa scale (NOS) for the quality assessment of included cohort studies and the Agency for Healthcare Research and Quality (AHRQ) for cross-sectional studies. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement’s guidelines were followed in this systematic study.ResultsIn all, 9,718 references were screened, of which 22 articles were included. A total of 15 CVD risk models were summarized. Except for the Cardiovascular Health in Ambulatory Care Research Team (CANHEART) health index, the other 14 CVD risk models were associated with dementia and cognitive decline. In comparison, different CVD risk models and domain-specific cognitive function correlation variation depended on cohort characteristics, risk models, cognitive function tests, and study designs. Moreover, it needed to be clarified when comparing the predicting performance of different CVD risk models.ConclusionIt is significant for public health to improve disease risk prediction and prevention and mitigate the potential adverse effects of the heart on the brain. More cohort studies are warranted to prove the correlation between CVD risk models and cognitive function. Moreover, further studies are encouraged to compare the efficacy of CVD risk models in predicting cognitive disorders.
Case report: Seropositive myasthenia gravis complicated by limbic encephalitis positive for antibodies to AMPAR and Lgi1
Authors: Nes Magne Solberg , Haugen Mette , Haugland Hans Kristian , Gilhus Nils Erik , Vedeler Christian Alexander 
Published: October 2023

ObjectivesAutoantibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and leucine-rich glioma-inactivated 1 (Lgi1) are associated with autoimmune encephalitis. We described an acetylcholine receptor (AChR)-positive patient with myasthenia gravis who developed limbic encephalitis with antibodies to AMPAR and Lgi1.MethodsA single-case report with detailed, prospective clinical and biomarker data including serial laboratory testing and histopathology.ResultsA 49-year-old woman was diagnosed with anti-AChR antibody-positive generalized myasthenia gravis in 1983. After 9 months of the removal of thymoma in 1984, she developed influenza-like symptoms and then symptoms of limbic encephalitis. Retrospective analysis of serum showed high concentrations of anti-AMPAR and lower concentrations of anti-Lgi1 antibodies. Cerebral CT was normal, EEG showed bifrontal dysrhythmia, and CSF showed mild pleocytosis. Immuno-histochemical examination of the thymoma confirmed staining for Glur2, a subunit of AMPAR. The patient recovered with mild sequelae, but low levels of anti-AMPAR and anti-Lgi1 antibodies were detectable for over 25 years subsequently.DiscussionThis case confirms earlier reports of AMPAR-associated autoimmune encephalitis co-occurring with thymoma and myasthenia gravis and is unique in its observational length. It shows, moreover, that antibodies to AMPAR and Lgi1 can persist despite clinical recovery.
A radiomics nomogram for predicting postoperative recurrence in esophageal squamous cell carcinoma
Authors: Tong Yahan , Chen Junyi , Sun Jingjing , Luo Taobo , Duan Shaofeng , Li Kai , Zhou Kefeng , Zeng Jian , Lu Fangxiao 
Published: October 2023

PurposeTo establish and validate a radiomics nomogram for predicting recurrence of esophageal squamous cell carcinoma (ESCC) after esophagectomy with curative intent.Materials and methodsThe medical records of 155 patients who underwent surgical treatment for pathologically confirmed ESCC were collected. Patients were randomly divided into a training group (n=109) and a validation group (n=46) in a 7:3 ratio. ​Tumor regions are accurately segmented in computed tomography images of enrolled patients. Radiomic features were then extracted from the segmented tumors. We selected the features by Max-relevance and min-redundancy (mRMR) and least absolute shrinkage and selection operator (LASSO) methods. A radiomics signature was then built by logistic regression analysis. To improve predictive performance, a radiomics nomogram that incorporated the radiomics signature and independent clinical predictors was built. Model performance was evaluated by receiver operating characteristic (ROC) curve, calibration curve, and decision curve analyses (DCA).ResultsWe selected the five most relevant radiomics features to construct the radiomics signature. The radiomics model had general discrimination ability with an area under the ROC curve (AUC) of 0.79 in the training set that was verified by an AUC of 0.76 in the validation set. The radiomics nomogram consisted of the radiomics signature, and N stage showed excellent predictive performance in the training and validation sets with AUCs of 0.85 and 0.83, respectively. Furthermore, calibration curves and the DCA analysis demonstrated good fit and clinical utility of the radiomics nomogram.ConclusionWe successfully established and validated a prediction model that combined radiomics features and N stage, which can be used to predict four-year recurrence risk in patients with ESCC who undergo surgery.
Plant growth and stress-regulating metabolite response to biochar utilization boost crop traits and soil health
Authors: Fallah Nyumah , Pang Ziqin , Lin Zhaoli , Lin Wenxiong , Mbuya Sylvain Ntambo , Abubakar Ahmad Yusuf , Fabrice Kabore Manegdebwaoga Arthur , Zhang Hua 
Published: October 2023

IntroductionThe utilization of biochar (BC) as a soil amendment in agriculture has gained significant traction among many farmers and researchers, primarily due to its eco-friendly role in boosting crop output. However, the performance of specific metabolites (e.g., zeatin, melatonin, sucrose, and phenyllactic acid) in the various tissues of sugarcane plant (leaf, stem, and root) and rhizosphere soil-deemed plant growth and stress regulators in a long-term BC-amended field remains poorly understood. Additionally, literature on the shift in soil attributes and crop growth triggered by the strong response of these bioactive compounds to longterm BC utilization remains undocumented.MethodsMetabolome integrated with highthroughput sequencing analyses were conducted to identify and quantify the performance of plant growth and stress-regulating metabolites in a long-term BC-amended field. Additionally, we investigated how the response of these compounds to BC-treated soil influences crop traits and soil biochemical properties.ResultsWe also identified and quantified the performance of pathogenic bacteria and unraveled the association between these compounds and potential plant growth-promoting bacteria. The BC-supplemented soil significantly boosted the crop traits, including brix, sucrose content, and chlorophyll, as well as soil nutrients, such as soil total nitrogen (TN), ammonium (NH4+-N), and nitrate (NO3--N). We also noticed that metabolite-deemed plant growth and stress regulators, including melatonin and phenyllactic acid, were enriched considerably in the stem and root tissues of the BC-amended soil. Zeatin in the leaf, stem, and root tissues exhibited the same trend, followed by sucrose in the leaf tissue of the BC-treated soil, implying that the strong response of these compounds to BC utilization contributed to the promotion of crop traits and soil quality. Pathogenic bacteria belonging to Proteobacteria and Acidobacteria were suppressed under the BC-supplemented soil, especially in the root tissue and rhizosphere soil, whereas plant growth-regulating bacteria, mainly Bradyrhizobium, responded strongly and positively to several metabolites.DiscussionOur finding provides valuable information for agronomists, farmers, and environmentalists to make informed decisions about crop production, land use, and soil management practices. Proper soil assessment and understanding of the interaction between the attributes of soil, BC, and metabolites are essential for promoting sustainable agriculture practices and land conservation.
Exploring college students’ continuance learning intention in data analysis technology courses: the moderating role of self-efficacy
Authors: Liu Liqiong , Ye Pinghao , Tan Joseph 
Published: October 2023

IntroductionIn today’s digital economy, data resources have gained strategic recognition. Enterprises view data analytic capabilities as a core organizational competitiveness. This study explored factors influencing college students’ continuance learning intention in data analysis technology courses to inform the role of self-efficacy on the relationship between interactivity and continuance learning intention.MethodsThe research model underpinning the study was based on the Stimulus-Organism-Response model and flow theory. The model was validated using SmartPLS. A total of 314 valid questionnaires were collected via the standard online survey approach.ResultsAmong internal factors, study results showed both cognitive interest and self-efficacy had significant positive effects on continuance learning intention. Also, cognitive interest had a significant positive effect on self-efficacy. Among external stimuli, content quality, software quality, and interactivity had significant positive effects on self-efficacy. Software quality did not have a significant effect on cognitive interest. Importantly, self-efficacy registered a significant moderating role on the relationship between interactivity and continuance learning intention.
Vowel perception in multilingual speakers: ERP evidence from Polish, English and Norwegian
Authors: Kędzierska Hanna , Rataj Karolina , Balas Anna , Cal Zuzanna , Castle Chloe , Wrembel Magdalena 
Published: October 2023

IntroductionResearch on Mismatch Negativity (MMN) in monolingual and bilingual speakers has shown significant differences in L1 versus L2 phonemic perception. In this study, we examined whether the MMN response is sensitive to the differences between L1, L2 and L3/Ln.MethodsWe compared bioelectrical brain activity in response to changes in pairs of vowels produced in three different languages. Specifically, multilingual participants listened to selected vowel contrasts in their L1 Polish, L2 English and L3/Ln Norwegian presented within the passive-oddball paradigm.ResultsResults revealed that the MMN was modulated by language: we observed significant differences between L2 English and L3/Ln Norwegian as well as between L1 Polish and L3/Ln Norwegian. For L3/Ln Norwegian, the MMN response had a lower amplitude when compared with L2 English and L1 Polish.DiscussionSuch findings suggest that foreign language status (i.e., L2 vs. L3/Ln) modulates early auditory processing.
Impact of the intensive psychological intervention care on post-traumatic stress disorder and negative emotions of teenage female patients seeking an induced abortion
Authors: Liu Huiling , Wu Fengdi , Liao Guixia , Mai Sizi , Ouyang Meijin 
Published: October 2023

AimThis study aimed to investigate the effects of intensive psychological intervention care on adverse emotions and post-traumatic stress disorder (PTSD) symptoms in female teenage patients after induced abortion.MethodsThis prospective cohort study included 100 teenage female patients seeking induced abortion who were randomly divided into two groups: the intervention group (n = 50) and the control group (n = 50). The intervention group received intensive psychological intervention care, while the control group received standard routine nursing. The scores of the PTSD checklist for DSM-5 (PCL-5), self-rating depression (SDS), and self-rating anxiety scale (SAS) were compared between the two groups at 1 month and 3 months after the operation.ResultsThe intervention group had lower risk of developing PTSD (24% vs. 44%), depression (10% vs. 32%), and anxiety (0% vs. 12%) symptoms at 1 month after the surgery. However, there were no significant differences observed between the two groups at 3 months after the surgery. Furthermore, the intervention group had significantly lower scores in PCL-5 (27.4 ± 5.4 vs. 31.8 ± 5.7; 20.5 ± 7.1 vs. 25.0 ± 7.5; p &lt; 0.05), SDS (31.8 ± 5.4 vs. 37.8 ± 6.6; 26.8 ± 5.0 vs. 31.4 ± 7.2; p &lt; 0.05), and SAS (32.7 ± 5.0 vs. 39.8 ± 6.9; 25.0 ± 2.7 vs. 27.5 ± 2.8; p &lt; 0.05) at 1 month and 3 months after induced abortion.ConclusionThese findings suggest that intensive psychological intervention care can reduce the incidence and severity of depression, anxiety, and PTSD symptoms in teenage patients who undergo induced abortion.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=185200, identifier ChiCTR2300067531.
The composition of the dental pellicle: an updated literature review
Authors: Enax Joachim , Ganss Bernhard , Amaechi Bennett T. , Schulze zur Wiesche Erik , Meyer Frederic 
Published: October 2023

BackgroundThe dental pellicle is a thin layer of up to several hundred nm in thickness, covering the tooth surface. It is known to protect the teeth from acid attacks through its selective permeability and it is involved in the remineralization process of the teeth. It functions also as binding site and source of nutrients for bacteria and conditioning biofilm (foundation) for dental plaque formation.MethodsFor this updated literature review, the PubMed database was searched for the dental pellicle and its composition.ResultsThe dental pellicle has been analyzed in the past years with various state-of-the art analytic techniques such as high-resolution microscopic techniques (e.g., scanning electron microscopy, atomic force microscopy), spectrophotometry, mass spectrometry, affinity chromatography, enzyme-linked immunosorbent assays (ELISA), and blotting-techniques (e.g., western blot). It consists of several different amino acids, proteins, and proteolytic protein fragments. Some studies also investigated other compounds of the pellicle, mainly fatty acids, and carbohydrates.ConclusionsThe dental pellicle is composed mainly of different proteins, but also fatty acids, and carbohydrates. Analysis with state-of-the-art analytical techniques have uncovered mainly acidic proline-rich proteins, amylase, cystatin, immunoglobulins, lysozyme, and mucins as main proteins of the dental pellicle. The pellicle has protective properties for the teeth. Further research is necessary to gain more knowledge about the role of the pellicle in the tooth remineralization process.
A Relationship Prediction Method for Magnaporthe oryzae–Rice Multi-Omics Data Based on WGCNA and Graph Autoencoder
Authors: Zhao Enshuang , Dong Liyan , Zhao Hengyi , Zhang Hao , Zhang Tianyue , Yuan Shuai , Jiao Jiao , Chen Kang , Sheng Jianhua , Yang Hongbo , Wang Pengyu , Li Guihua , Qin Qingming 
Published: October 2023

Magnaporthe oryzae Oryzae (MoO) pathotype is a devastating fungal pathogen of rice; however, its pathogenic mechanism remains poorly understood. The current research is primarily focused on single-omics data, which is insufficient to capture the complex cross-kingdom regulatory interactions between MoO and rice. To address this limitation, we proposed a novel method called Weighted Gene Autoencoder Multi-Omics Relationship Prediction (WGAEMRP), which combines weighted gene co-expression network analysis (WGCNA) and graph autoencoder to predict the relationship between MoO–rice multi-omics data. We applied WGAEMRP to construct a MoO–rice multi-omics heterogeneous interaction network, which identified 18 MoO small RNAs (sRNAs), 17 rice genes, 26 rice mRNAs, and 28 rice proteins among the key biomolecules. Most of the mined functional modules and enriched pathways were related to gene expression, protein composition, transportation, and metabolic processes, reflecting the infection mechanism of MoO. Compared to previous studies, WGAEMRP significantly improves the efficiency and accuracy of multi-omics data integration and analysis. This approach lays out a solid data foundation for studying the biological process of MoO infecting rice, refining the regulatory network of pathogenic markers, and providing new insights for developing disease-resistant rice varieties.
Analisis Faktor Strategi Pengembangan UMKM Kelurahan Pabuaran Kota Bogor
Authors: Nurvi Oktiani  , SAFRIA Dhuha 
Published: October 2023

The Improvement and Development of Micro, Small and Medium Enterprises are priority for making economic and sustainable development where that is one of Economic foundation especially in Indonesia, beside that the small, medium enterprises as a sector which have important role because consist of full activities and can make expand employment, however and must be understanding, because of covid -19 disease give impact and change for all aspects, especially for continuity developing micro, small and medium enterprises .The purpose of research analyze and explain factors for developing which can be implemented strategy micro, small and medium enterprises in Pabuaran, Bogor city. The research of Method uses quantitative Descriptive, the source of data has been obtained by questionnaire toward fifty respondent, the data analyze has been obtained by factor analysis with data processing by determining of Index KMO, measure of sampling adequate, communalities values, total variant explained, rotated component matrix, From the result can be obtained from twenty variable have been reduced become sixteen variable, and three Factors include of resources and capabilities or process technic capacity, market regulation and SME regulation, employee skill. From the three factors can be determinant that the dominant factors for making development micro, small and medium enterprises is Resources and capabilities process Technic Capasity
Preparasi Nanopartikel Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) dengan Variasi Konsentrasi Kitosan dan Tripolifosfat Sebagai Kandidat Antioksidan
Authors: Dewanti Aprilia Ayu , Disa Andriani  , Utami Nastiti 
Published: October 2023

Telang flower has antioxidant activity, one of which is due to the content of flavanoids in it, but these flavanoids are unstable to temperature and light intensity. One of the efforts to overcome this problem is to change the dosage size to nanoparticles. This study aims to determine which preparations are included in the nano size range and have antioxidant activity in them.The research method was experimental with maceration extraction method using 70% ethanol solvent. The extract that has been obtained is made into nanoparticle preparations. Nanoparticle preparations were made with various concentrations of chitosan, namely F1 0.1%; F2 0.3%; and F3 0.5%. Testing of nanoparticles included particle size testing using a Particle Size Analyzer (PSA), then continued testing for antioxidant activity using the DPPH method. The results of ethanol extraction of telang flowers obtained a yield of 30.94%. Particle size test results from F1 142.3 ± 8.76 nm, F2 163.13 ± 15.82 nm and F3 724.97 ± 51.58 nm. Meanwhile, for the antioxidant activity test, IC50 values were obtained for F1 8.17 ± 0.090 ppm, F2 7.56 ± 0.180 ppm, and F3 6.97 ± 0.082 ppm, and. The conclusion of this study is that the particle sizes for F1, F2, and F3 meet the size range of nanoparticles. Meanwhile, the results of antioxidant activity for all formulas had antioxidant activity in the strong category, for the formula with the strongest antioxidant activity was F3.
ABSTRAK
Bunga telang mempunyai aktivitas antioksidan salah satunya dikarenakan kandungan flavanoid didalamnya, namun flavanoid ini tidak stabil terhadap suhu dan intensitas cahaya. Upaya untuk mengatasi masalah tersebut salah satunya dengan merubah ukuran sediaan menjadi nanopartikel. Penelitian ini bertujuan mengetahui sediaan yang termasuk dalam rentang ukuran nano dan mempunyai aktivitas antioksidan didalamnya. Metode penelitian adalah eksperimental dengan metode ekstraksi maserasi menggunakan pelarut etanol 70%. Ekstrak yang sudah didapatkan dibuat menjadi sediaan nanopartikel. Sediaan nanopartikel dibuat dengan variasi konsentrasi kitosan yaitu F1 0,1%; F2 0,3%; dan F3 0,5%. Pengujian nanopartikel meliputi uji ukuran partikel menggunakan Particle Size Analyzer (PSA), kemudian dilanjutkan pengujian aktivitas antioksidan menggunakan metode DPPH. Hasil ekstraksi etanol bunga telang didapatkan rendemen sebesar 30,94%. Hasil uji ukuran partikel dari F1 142,3±8,76 nm, F2 163,13±15,82 nm dan F3 724,97±51,58 nm. Sementara untuk uji aktivitas antioksidan diperoleh nilai IC50 pada F1 8,17±0,090 ppm, F2 7,56±0,180 ppm, dan F3 6,97±0,082 ppm, dan. Kesimpulan penelitian ini adalah ukuran partikel untuk F1, F2, dan F3 memenuhi rentang ukuran nanopartikel. Sementara itu, hasil aktivitas antioksidan untuk semua formula memiliki aktivitas antioksidan dengan kategori kuat, untuk formula yang paling kuat antioksidannya adalah F3.
Ketepatan Pemilihan Peresepan Antibiotik untuk Terapi Pneumonia pada Pasien Lansia Rawat Inap di Rumah Sakit X Surakarta
Authors: Rahardjoputro Rolando , Sholihah Inayatush , Amrullah Adhi Wardhana 
Published: October 2023

Pneumonia is an infectious disease often suffered by geriatric patients in Indonesia and the world. The aim is to analyze the rationality of antibiotics for pneumonia in geriatric inpatients. The rational analysis method for prescribing antibiotics in this study uses the Gyssens method as one of the methods in medical research used to determine the rationale for administering antibiotics. This research is a descriptive observational study with a cross-sectional method. Data were obtained from a retrospective search of medical records from January to December 2020 in the medical records section of Hospital X Surakarta. The results showed that the use of most antibiotics for geriatric patients with pneumonia were levofloxacine (60%), ceftriaxone (26.67%), cefotaxime (13.34%), ceftazidime (13.34%), and azithromycin (13.34%) ). The rationality analysis of Gyssens method obtained IVA category 33.34%, IVB category 60% and 0 category 6.66%. It can be concluded that prescribing antibiotics for pneumonia in geriatric patients hospitalized at X Hospital Surakarta is still not rational.
ABSTRAK
Pneumonia merupakan penyakit infeksi yang sering diderita oleh pasien geriatri di Indonesia dan dunia. Tujuan penelitian ini yaitu menganalisis rasionalitas antibiotik untuk pneumonia pada pasien geriatri rawat inap. Metode analisis rasionalitas peresepan antibiotik pada penelitian ini menggunakan metode Gyssens sebagai salah satu metode dalam penelitian kesehatan yang digunakan untuk menentukan rasionalitas pemberian antibiotik. Penelitian ini merupakan penelitian observasional deskriptif dengan metode cross-sectional. Data diperoleh dari penelusuran retrospektif rekam medis periode Januari hingga Desember tahun 2020 di bagian rekam medis Rumah Sakit X Surakarta. Hasil: Hasil penelitian menunjukkan bahwa penggunaan antibiotik terbanyak pada pasien geriatri dengan pneumonia adalah levofloksasin (60%), seftriakson (26,67%), sefotaksim (13,34%), seftazidim (13,34%), dan azitromisin (13,34%). Analisis rasionalitas metode Gyssens diperoleh kategori IVA 33,34%, kategori IVB 60% dan kategori 0 6,66%. Dapat disimpulkan bahwa peresepan antibiotik untuk pneumonia pada pasien geriatri yang rawat inap di rumah sakit X Surakarta masih belum rasional.