bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the likelihood of hypothyroidism in dogs diagnosed with and treated for hypothyroidism at primary care practices: 102 cases (2016‐2021)
Authors: Travail Victoria , Fernandez Sanchez Carolina , Costo Jose M. , Valentine Nicola , Conroy Megan , Lee Venessa , Bouziopoulos Dimitrios , Bateman Kathryn , Gatehouse Emma , Cruzado‐Perez Judith , Pollard Danica , Lamb Valerie , Juvet Florence , Kelly Darren 
Published: February 2024

AbstractBackgroundThere is a possibility that an incorrect diagnosis of hypothyroidism could be made in euthyroid dogs, and the prevalence of hypothyroidism in the dog population remains unknown.ObjectivesTo retrospectively assess the percentage of dogs diagnosed with, and treated for, hypothyroidism at first opinion practice which are likely to be hypothyroid and require levothyroxine supplementation.AnimalsOne hundred two client‐owned dogs were included in this study.Materials and MethodsThe computerized databases of 7 first opinion practices were searched to identify dogs treated with levothyroxine supplementation. Three European College of Veterinary Internal Medicine—Companian Animals (ECVIM‐CA) diplomates independently assigned 1 of 4 clinical assessments to each case as follows: confirmed or likely hypothyroid, hypothyroidism suspected but not confirmed, hypothyroidism considered unlikely, and no reason to suspect hypothyroidism. They commented as to whether or not they thought levothyroxine supplementation was appropriate.ResultsThe clinical assessments of “confirmed or likely hypothyroid”; “Hypothyroidism suspected but not confirmed”; “Hypothyroidism considered unlikely”; and “No reason to suspect hypothyroidism” was assigned respectively by Clinician 1 to 38.2%, 5.9%, 3.9%, and 52% of cases, by Clinician 2 to 48%, 22.6%, 22.6%, 6.9% of cases, and by Clinician 3 to 55.9%, 11.8%, 13.7% and 18.6%. Clinician 1, Clinician 2, and Clinician 3 considered levothyroxine supplementation not indicated in 58.8%, 52.9%, and 45.1% of cases, respectively.ConclusionThese results support the concern that hypothyroidism might be overly and incorrectly diagnosed in first opinion practice, and that thyroid function testing should be performed only in those dogs with a high pretest probability of the disease.
Reason for euthanasia in dogs with urothelial carcinoma treated with chemotherapy or radiation therapy or both: A retrospective observational study
Authors: McKenna Charly , Poirier Valerie J. , Oblak Michelle L. , Nykamp Stephanie , Mutsaers Anthony J. 
Published: February 2024

AbstractBackgroundClients want to know the ultimate cause of death in their pet after cancer treatment. The cause of euthanasia and investigation of urinary obstruction in treated dogs with urothelial carcinoma (UC) has not been specifically reported in veterinary literature.Hypothesis/ObjectivesOur hypothesis was that the majority of treated dogs with UC are euthanized secondary to primary tumor factors, such as urinary obstruction.AnimalsFifty‐nine client‐owned dogs diagnosed with UC.MethodsRetrospective observational study on clinical signs and disease at euthanasia of dogs with UC treated by radiation therapy or chemotherapy or both.ResultsThe median overall survival time (OST) of all dogs was 339 days (range, 17‐1996; 95% confidence interval [CI], 185‐392; interquartile range [IQR], 112‐505). Of dogs deemed to have been euthanized because of UC (50/59, 85%), the primary cause was considered to be local progression in 31/50 (62%), most often because of perceived complete or partial urinary obstruction (24/31, 77%). No variables were found to be predictive of urinary obstruction. The overall documented metastatic rate was 56%. In dogs euthanized because of UC, metastasis was deemed to be the cause in 19/50 (38%) dogs.Conclusions and Clinical ImportanceRegardless of the type of treatment, UC in dogs has a poor prognosis and there is a continuing need to improve treatments that focus on local control of the primary tumor, given its high contribution to the decision for euthanasia. Proactive management to avoid the high frequency of urinary obstruction may be worthy of future investigation.
Bertrand‐Cournot profit reversal under non‐commitment process innovation
Authors: Zhang Qidi , Wang Leonard F. S. , Mukherjee Arijit 
Published: February 2024

AbstractWe provide a new reason for Bertrand‐Cournot profit reversal. In a symmetric oligopoly, we show that firms get higher profits under Bertrand competition compared to Cournot competition under non‐commitment process innovation if the products are sufficiently differentiated and there is positive knowledge spillover. As the number of firms increases, the degree of product differentiation over which the profits are higher under Bertrand competition can increase. Higher outputs under Bertrand competition compared to Cournot competition generate higher R&D investments under the former than the latter, which is responsible for our result.
International expert meeting on the donation and use of human milk: Brief report
Authors: Weaver Gillian , Chatzixiros Efstratios , Biller‐Andorno Nikola , Grummer‐Strawn Laurence ,   the Human Milk Banking Consultative Working Group
Published: February 2024

AbstractWhere a mother's own milk is not available or is insufficient, donor human milk (DHM) processed by a human milk bank (HMB) is the recommended next best alternative. HMBs exist in over 65 countries. However, most countries have yet to establish national policies or programmes that support the provision of DHM. In July 2019, a group of international experts in fields relevant to human milk banking gathered at a meeting organised by the Institute of Biomedical Ethics, University of Zurich, and co‐sponsored by the World Health Organisation. Prompted by the growing interest globally in creating and sustaining HMBs and addressing current safety and ethical concerns and standards, the aims of the meeting were to define knowledge gaps, determine the need for and scope of global guidelines and provide recommendations on steps that need to be taken at the international level. Following wide‐ranging discussions that included the integration of milk banks into health care systems, strategy and policy, quality and safety, the use of DHM and associated ethical considerations, the overall conclusion of the meeting was that in the absence of global recommendations on the implementation, operation and regulation of HMBs, evidence‐based guidance is urgently needed.
The interplay between memory control and emotion regulation
Authors: Luo Yun , Wang Rui , Xie Hui , He Zhenhong 
Published: February 2024

AbstractMemory control (MC) and emotion regulation (ER) are critical cognitive functions for adapting to life's challenges, drawing significant research attention. Accumulating evidence suggests these processes are interrelated, yet a comprehensive discussion of their interplay remains lacking. We introduce an integrative framework exploring the mutual influence between MC and ER, composed of two interrelated branches: first, MC aids in ER through the retrieval of positive memories, intentional forgetting of undesirable content, and the adaptive updating of memory stores. Second, ER impacts MC by upregulating positivity and downregulating negativity in memories. The framework spotlights the need to harness MC–ER interplay for future research. Potential directions include utilizing MC to amplify ER capabilities, training ER skills to refine MC performance, and modulating the cognitive and neural overlapping of both processes to improve both functions. Delving into the MC–ER nexus advances understanding of the intricate emotion–memory relationship and holds great promise for developing novel behavioral interventions.
Characteristics and outcomes of peripheral neuropathic pain patients with repeated applications of high‐concentration capsaicin cutaneous patch: Results of a retrospective chart review in Germany
Authors: Kern Kai‐Uwe , Quandel Tamara , Theis Sina , Schubert Tino 
Published: February 2024

AbstractObjectiveThe aim of this study was to evaluate patient characteristics, concomitant analgesic medication, and pain intensity in a real‐world setting in Germany, focusing on the repeated application of high‐concentration capsaicin patch (HCCP) for neuropathic pain.DesignData were collected from electronic medical records of patients who received at least two HCCP treatments between January 2011 and July 2022. Subgroup analyses were performed based on the number of HCCP treatments, age groups, and specific neuropathic pain conditions.SettingThe study was conducted at an outpatient pain center in Wiesbaden, Germany.SubjectsThe study included 97 patients, primarily diagnosed with neuropathic back pain, postoperative or post‐traumatic neuropathic pain, and postherpetic neuralgia.MethodsThe daily dose of concomitant medications (eg, opioids and anticonvulsants) at the start of capsaicin therapy was compared with the average within 2 years of capsaicin therapy. The last observation carried forward method was used if HCCP treatment was discontinued before the end of the 2‐year period.ResultsThe majority of patients received concomitant medications, with opioids, anticonvulsants, and antidepressants being the most common. The average daily morphine equivalent dose decreased significantly during HCCP treatment. Pain intensity at baseline was generally high, but substantial improvements were observed in patients who received at least three HCCP applications.ConclusionsThis study provides evidence for the effectiveness of HCCP treatment in reducing pain intensity and concomitant opioid use in patients with neuropathic pain. Further research is needed to explore the long‐term outcomes and optimal treatment regimens for different patient populations.
Calmodulin‐like protein CML15 interacts with PP2C46/65 to regulate papaya fruit ripening via integrating calcium, ABA and ethylene signals
Authors: Zhu Qiunan , Tan Qinqin , Gao Qiyang , Zheng Senlin , Chen Weixin , Galaud Jean‐Philippe , Li Xueping , Zhu Xiaoyang 
Published: February 2024

SummaryIt is well known that calcium, ethylene and abscisic acid (ABA) can regulate fruit ripening, however, their interaction in the regulation of fruit ripening has not yet been fully clarified. The present study found that the expression of the papaya calcium sensor CpCML15 was strongly linked to fruit ripening. CpCML15 could bind Ca2+ and served as a true calcium sensor. CpCML15 interacted with CpPP2C46 and CpPP2C65, the candidate components of the ABA signalling pathways. CpPP2C46/65 expression was also related to fruit ripening and regulated by ethylene. CpCML15 was located in the nucleus and CpPP2C46/65 were located in both the nucleus and membrane. The interaction between CpCML15 and CpPP2C46/65 was calcium dependent and further repressed the activity of CpPP2C46/65 in vitro. The transient overexpression of CpCML15 and CpPP2C46/65 in papaya promoted fruit ripening and gene expression related to ripening. The reduced expression of CpCML15 and CpPP2C46/65 by virus‐induced gene silencing delayed fruit colouring and softening and repressed the expression of genes related to ethylene signalling and softening. Moreover, ectopic overexpression of CpCML15 in tomato fruit also promoted fruit softening and ripening by increasing ethylene production and enhancing gene expression related to ripening. Additionally, CpPP2C46 interacted with CpABI5, and CpPP2C65 interacted with CpERF003‐like, two transcriptional factors in ABA and ethylene signalling pathways that are closely related to fruit ripening. Taken together, our results showed that CpCML15 and CpPP2Cs positively regulated fruit ripening, and their interaction integrated the cross‐talk of calcium, ABA and ethylene signals in fruit ripening through the CpCML15‐CpPP2Cs‐CpABI5/CpERF003‐like pathway.
The legacy of past droughts induces water‐sparingly behaviour in Grüner Veltliner grapevines
Authors: Herrera J. C. , Savoi S. , Dostal J. , Elezovic K. , Chatzisavva M. , Forneck A. , Savi T. 
Published: February 2024

Abstract
Drought is becoming more frequent and severe in numerous wine‐growing regions. Nevertheless, limited research has examined the legacy of recurrent droughts, focusing on leaf physiology and anatomy over consecutive seasons.
We investigated drought legacies (after 2 years of drought exposure) in potted grapevines, focusing on stomatal behaviour under well‐watered conditions during the third year. Vines were subjected for two consecutive years to short‐ (SD) or long‐term (LD) seasonal droughts, or well‐watered conditions (WW). In the third year, all plants were grown without water limitation. Water potential and gas exchange were monitored throughout the three seasons, while leaf morpho‐anatomical traits were measured at the end of the third year.
During droughts (1st and 2nd year), stem water potential of SD and LD plants fell below −1.1 MPa, with a consequent 75% reduction in stomatal conductance (gs) compared to WW. In the 3rd year, when all vines were daily irrigated to soil capacity (midday stem water potential ~ −0.3 MPa), 45% lower values of gs were observed in the ex‐LD group compared to both ex‐SD and ex‐WW. Reduced midrib vessel diameter, lower leaf theoretical hydraulic conductivity, and smaller stomata were measured in ex‐LD leaves compared to ex‐SD and ex‐WW, likely contributing to the reduced gas exchange.
Our findings suggest that grapevines exposed to drought may adopt a more water‐conserving strategy in subsequent seasons, irrespective of current soil water availability, with the degree of change influenced by the intensity and duration of past drought events.
Does effort increase or decrease reward valuation? Considerations from cognitive dissonance theory
Authors: Harmon‐Jones Eddie , Matis Sophie , Angus Douglas J. , Harmon‐Jones Cindy 
Published: February 2024

AbstractThe present research tested the effect of manipulated perceived control (over obtaining the outcomes) and effort on reward valuation using the event‐related potential known as the Reward Positivity (RewP). This test was conducted in an attempt to integrate two research literatures with opposite findings: Effort justification occurs when high effort leads to high reward valuation, whereas effort discounting occurs when high effort leads to low reward valuation. Based on an examination of past methods used in these literatures, we predicted that perceived control and effort would interactively influence RewP. Consistent with the effort justification literature (cognitive dissonance theory), when individuals have high perceived control, high effort should lead to more reward valuation than low effort should. Consistent with the effort discounting literature, when individuals have low perceived control, low effort should lead to more reward valuation than high effort should. Results supported these interactive and integrative predictions.
Everyday market nationalism: The nationhood imaginative value and nationalistic economic habitus on the Indonesian ride hailing commodity “Gojek”
Authors: Herwantoko One , Hardjosoekarto Sudarsono , Adnan Ricardi S. 
Published: February 2024

AbstractThis article investigates everyday market nationalism as a construction of nationalism in everyday social interactions in the market field and reflected in the existence of an imaginative value of nationalism in a commodity. Focusing on the market field of ride hailing commodity Gojek and using a mixed method, this study shows that the imaginative value of Indonesian nationalism in Gojek is influenced by economic, cultural, symbolic, and digital capital as well as socio‐demographic characteristics of the actors and associated with nationalistic economic habitus formed through social practices in the market field of Gojek.
Nuancing Regional Geography: An Analysis of the Evolution and Mechanism of Intercity Cooperation Network in the Guangdong‐Hong Kong‐Macao Greater Bay Area
Authors: Tang Chenghui , Zhang Xianchun , Cheung Darren Man‐Wai 
Published: February 2024

AbstractThis article presents an analysis of the evolution and mechanisms of the intercity cooperation network of the Guangdong‐Hong Kong‐Macao Greater Bay Area (GBA). Based on spatial analysis, social network analysis, and zero‐inflated negative binomial regression analysis, the following key findings are reported: First, the GBA's intercity cooperation network unfolds a strong trend away from a centralized structure towards a polycentric pattern and networked regional governance. Second, the GBA's intercity cooperation is marked by unevenness and path dependence, with high‐level linkages almost exclusively the purview of the area's most economically developed cities. Third, heavily cultivated by economic globalization and national power, the heightening of intercity cooperation is the result of condensed switching among jurisdictions where both endogenous and exogenous factors have rearranged and characterized by uneven development trends.
CsPAT1, a GRAS transcription factor, promotes lignin accumulation by antagonistic interacting with CsWRKY13 in tea plants
Authors: Li Jing‐Wen , Zhou Ping , Hu Zhi‐Hang , Teng Rui‐Min , Wang Yong‐Xin , Li Tong , Xiong Ai‐Sheng , Li Xing‐Hui , Chen Xuan , Zhuang Jing 
Published: February 2024

SUMMARYLignin is an important component of plant cell walls and plays crucial roles in the essential agronomic traits of tea quality and tenderness. However, the molecular mechanisms underlying the regulation of lignin biosynthesis in tea plants remain unclear. CsWRKY13 acts as a negative regulator of lignin biosynthesis in tea plants. In this study, we identified a GRAS transcription factor, phytochrome A signal transduction 1 (CsPAT1), that interacts with CsWRKY13. Silencing CsPAT1 expression in tea plants and heterologous overexpression in Arabidopsis demonstrated that CsPAT1 positively regulates lignin accumulation. Further investigation revealed that CsWRKY13 directly binds to the promoters of CsPAL and CsC4H and suppresses transcription of CsPAL and CsC4H. CsPAT1 indirectly affects the promoter activities of CsPAL and CsC4H by interacting with CsWRKY13, thereby facilitating lignin biosynthesis in tea plants. Compared with the expression of CsWRKY13 alone, the co‐expression of CsPAT1 and CsWRKY13 in Oryza sativa significantly increased lignin biosynthesis. Conversely, compared with the expression of CsPAT1 alone, the co‐expression of CsPAT1 and CsWRKY13 in O. sativa significantly reduced lignin accumulation. These results demonstrated the antagonistic regulation of the lignin biosynthesis pathway by CsPAT1 and CsWRKY13. These findings improve our understanding of lignin biosynthesis mechanisms in tea plants and provide insights into the role of the GRAS transcription factor family in lignin accumulation.
Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Results of a pilot randomized trial RBC‐ENHANCE
Authors: Buckstein Rena , Callum Jeannie , Prica Anca , Bowen David , Wells Richard A. , Leber Brian , Heddle Nancy , Chodirker Lisa , Cheung Matthew , Mozessohn Lee , Yee Karen , Gallagher Jennifer , Parmentier Anne , Jamula Erin , Zhang Liying , Mamedov Alex , Stanworth Simon J. , Lin Yulia 
Published: February 2024

AbstractBackgroundThe optimal hemoglobin (Hb) threshold for red blood cell transfusions in adult patients with myelodysplastic syndromes (MDS) has not been defined.Study Design and MethodsWe conducted a pilot randomized multi‐center study of two transfusion algorithms (liberal, to maintain Hb 110–120 g/L, transfuse 2 units if Hb < 105 g/L and 1 unit if Hb 105–110 g/L vs. restrictive, 85–105 g/L, transfuse 2 units when Hgb < 85 g/L). Primary objectives were 70% compliance in maintaining the q2 week hemoglobin within the targeted range and the achievement of a 15 g/L difference in pre‐transfusion Hb. Secondary outcomes included measures of quality of life (QOL), iron studies and safety.ResultsTwenty‐eight patients were randomized between February 2015–2020, 13 to the restrictive arm and 15 to the liberal arm in three tertiary care centers. The compliance was 66% and 45% and the mean pre‐transfusion Hb thresholds were 86 (standard deviation [SD] 8) and 98 g/L (SD 10) in the restrictive and liberal arms, (mean difference 11.8 g/L, p < .0001), respectively. Patients in the liberal arm experienced a mean of 3.4 (SD 2.6) more transfusion visits and received a mean of 5.3 (SD 5.5) more units of blood during the 12‐week study. Ferritin increased by 1043 (SD 1516) IU/L and 148 (SD 1319) IU/L in the liberal and restrictive arms, respectively. Selected QOL scores were superior pre‐transfusion and more patients achieved clinically important improvements in the liberal arm compared with the restrictive arm for selected symptoms and function domains.ConclusionThe results establish that policies for transfusion support can be delivered in practice at multiple hospitals, but further research is required to understand the full clinical effects and safety of liberal transfusion policies in MDS outpatients.
Analytical performance of feline plasma on current Heska and IDEXX point‐of‐care biochemistry analyzers compared with a commercial laboratory analyzer
Authors: Baral Randolph M. , Jaensch Susan M. , Hayward Douglas A. , Freeman Kathleen P. 
Published: February 2024

AbstractBackgroundPoint‐of‐care (POC) biochemistry analyzers are widely used in small animal clinical practice but infrequently independently assessed for performance.ObjectiveTo assess the performance of two current model point‐of‐care biochemistry analyzers (Heska Element DC and IDEXX Catalyst) compared with a commercial laboratory analyzer (Cobas 8000).MethodsOne hundred twenty‐one cats from a feline hospital population were sampled with plasma results from a single lithium heparin tube assessed on all three analyzers. Plasma biochemistry results from each POC analyzer were compared with the commercial laboratory analyzer using Bland–Altman difference plots and by determining whether the limits of agreement (LOAs) (95% of differences) fell within various quality goals after correcting for inherent bias.ResultsOnly 7 of 14 analytes on the Heska analyzer and 2 analytes on the IDEXX analyzer attained the most stringent LOA quality goal, which was being within desirable total error based on biologic variation (TEdes). The number of analytes achieving quality goals increased with less stringent standards such as American Society of Veterinary Clinical Pathologists allowable total error (ASVCP TEA) guidelines or if <95% of clinical comparisons reaching these quality goals is considered acceptable. Widespread bias was found between both POC analyzers and the commercial laboratory analyzer.ConclusionsThe performance of both POC biochemistry analyzers was variable compared with a commercial laboratory analyzer. Performance goals were only able to be attained after the bias for each analyzer was accounted for by offsetting the LOAs and quality goals set by the mean bias for each analyte on each analyzer.