bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design optimization of a grid-tied microgrid for a residential community in southern Bangladesh
Authors: Hasan Sayeed , Hazari Md. Rifat , Jahan Effat , Mannan Mohammad Abdul 
Published: November 2023

Abstract
Growing energy demand, diminishing fossil fuel reserves and geopolitical tensions are serious concerns for any country’s energy strategy and security. These factors have a greater impact on developing countries, as many of them rely largely on traditional energy resources. Cleaner energy generation is the viable alternative for mitigating these problems, as well as achieving energy independence and tackling climate change. The article discusses planning and design optimization of a residential community microgrid based on multiple renewable resources. In particular, the design and techno-economic assessment of a grid-tied hybrid microgrid for meeting the electricity demand of an alluvial region, Urir Char, located in southern Bangladesh, was addressed. Hybrid Optimization of Multiple Energy Resources is used for the evaluation and it is supplemented by a fuzzy-logic-based load profile design strategy. In addition to the analysis, a predictive load-shifting-based demand management is also introduced. Several cases were considered for the studies and, after considering several criteria, a grid-tied system comprising a photovoltaic array, wind turbine and energy storage system was found to be the best fit for powering the loads. The suggested system reduces the life-cycle cost by 18.3%, the levelized cost of energy by 61.9% and emissions by 77.2% when compared with the grid-only option. Along with the microgrid design, cooking emissions and energy categorization were also discussed.
High-tech development for “left behind” places: lessons-learnt from the Ruhr cybersecurity ecosystem
Authors: Butzin Anna , Flögel Franz 
Published: November 2023

Abstract
Unlike development strategies for prosperous regions and their prioritisation of high-tech sectors, alternative strategies for left behind places are suggested that shift to foundational economies, community-based social innovation and well-being. While we support this emphasis, we see a tendency to neglect the role of change agents engaged with research and teaching in high-tech domains for initiating new regional growth paths. This study shows how initial funding has promoted change agents and the emergence of today’s cybersecurity ecosystem in the old industrial region of the Ruhr. The ecosystem generates fast-growing high-tech start-ups and contributes to positive regional identification. Our paper suggests combining alternative development strategies and the support of change agency from high-tech domains to develop left behind places.
Lesser mealworm Alphitobius diaperinus (Coleoptera: Tenebrionidae) displays negative phototaxis and conditional hygrotaxis
Authors: Sammarco Ben C , Crossley Michael S 
Published: November 2023

Abstract
Arthropods use a variety of environmental cues to navigate between and locate hosts. In agricultural systems, clarifying the relevant cues and their effects on arthropod behavior can inform management practices to reduce or inhibit the activity of arthropod pests. The lesser mealworm Alphitobius diaperinus (Panzer) is a ubiquitous arthropod pest of broiler house chicken production, and while the patterns of movement and behavior of A. diaperinus are well documented, the specific environmental factors that govern these patterns are not known. We conducted behavioral assays testing the response of A. diaperinus adults and larvae to different wavelengths of light and to the presence of water. Alphitobius diaperinus displayed a significant repulsion from white, green, red, and blue light, while larvae consistently sought shelter and displayed no behavioral change in response to light. Dehydrated adult beetles displayed an attraction to water while hydrated beetles displayed a repulsion to water. Regardless of the availability of water, dehydrated beetles displayed a reduced repulsion from light. Taken together, these results indicate that A. diaperinus will hide from sources of light unless they are dehydrated. Knowledge of the environmental cues that influence the behavior of A. diaperinus could be used to improve methods of trapping, monitoring, and controlling populations of A. diaperinus in experimental and commercial settings.
Rapid atrial pacing above the maximum sensor rate: a case report
Authors: Bodziock George M , Kozak Patrick M , Pruitt Carrie , Dillon John F , Bhave Prashant D 
Published: November 2023

Abstract

Background
While ventricular-based timing modes are known to cause elevated atrial pacing above the lower rate when intrinsic atrioventricular (AV) conduction is shorter than programmed AV delay, there is one case report in 2015 by Jafri et al. where rapid atrial pacing was induced in an Abbott device set DDI with a lower rate of 90 by an unsensed premature atrial complex and slow intrinsic AV conduction allowing pacemaker ‘crossover.’

Case summary
We present a very unusual case of rapid atrial pacing at &gt;180 b.p.m. due to a perfect storm of events that we believe has not been previously reported. A patient with a St. Jude Abbott DCPPM set DDDR had an atrial tachyarrhythmia causing a mode switch to DDIR, which uses ventricular-based timing. This was followed by a period of rapid atrial pacing that terminated spontaneously.

Discussion
This phenomenon depended on an initial atrial tachyarrhythmia causing a mode switch to DDIR. In addition, the set lower rate would not have led to a short enough calculated ventriculo-atrial interval (VAI), but because rate responsive pacing was enabled, the calculated VAI was short enough to promote the crossover in setting of slow AV conduction and allow the rapid atrial pacing. Understanding this unique mechanism requires careful attention to pacemaker timing cycles and appreciation of the limitations of device programming. While it appears that a similar phenomenon was reported once in the literature, we believe that this episode of rapid atrial pacing was even more serendipitous due to the unlikely series of events required for its inception.
Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study
Authors: Katsoularis Ioannis , Jerndal Hanna , Kalucza Sebastian , Lindmark Krister , Fonseca-Rodríguez Osvaldo , Connolly Anne-Marie Fors 
Published: November 2023

Abstract

Aims
COVID-19 increases the risk of cardiovascular disease, especially thrombotic complications. There is less knowledge on the risk of arrhythmias after COVID-19. In this study, we aimed to quantify the risk of arrhythmias following COVID-19.

Methods and results
This study was based on national register data on all individuals in Sweden who tested positive for SARS-CoV-2 between 1 February 2020 and 25 May 2021. The outcome was incident cardiac arrhythmias, defined as international classification of diseases (10th revision) codes in the registers as follows: atrial arrhythmias; paroxysmal supraventricular tachycardias; bradyarrhythmias; and ventricular arrhythmias. A self-controlled case series study and a matched cohort study, using conditional Poisson regression, were performed to determine the incidence rate ratio and risk ratio, respectively, for an arrhythmia event following COVID-19.A total of 1 057 174 exposed (COVID-19) individuals were included in the study as well as 4 074 844 matched unexposed individuals. The incidence rate ratio of atrial tachycardias, paroxysmal supraventricular tachycardias, and bradyarrhythmias was significantly increased up to 60, 180, and 14 days after COVID-19, respectively. In the matched cohort study, the risk ratio during Days 1–30 following COVID-19/index date was 12.28 (10.79–13.96), 5.26 (3.74–7.42), and 3.36 (2.42–4.68), respectively, for the three outcomes. The risks were generally higher in older individuals, in unvaccinated individuals, and in individuals with more severe COVID-19. The risk of ventricular arrhythmias was not increased.

Conclusion
There is an increased risk of cardiac arrhythmias following COVID-19, and particularly increased in elderly vulnerable individuals, as well as in individuals with severe COVID-19.
Discrimination of pharmacodynamic components and volatile compounds of Poria cocos cultivated with five different materials based on GC-IMS analysis
Authors: Wang Yinan , Zhou Fei , Wang Hui , Zhang Jinping , Xu Hongxia 
Published: November 2023

Abstract

Objectives
The chemical constituents of Poria cocos grown with different substrates vary significantly; thus, identifying and comparing their biomarkers are important.

Materials and Methods
Herein, the chemical constituents of Poria cocos obtained with five different substrates were assessed using gas chromatography–ion mobility spectrometry (GC-IMS), high-performance liquid chromatography and multivariate statistical analysis.

Results
The content of moisture, ash, alcohol-soluble matter, and heavy metals, except for those of the miscellaneous wood Poria cocos, conform to the specifications defined in the Chinese Pharmacopoeia (Edition 2020), and the polysaccharide contents are all greater than 57%.

Conclusions
Based on GC-IMS and the established fingerprints, 87 compounds were detected, 70 of which were identified in each group. Multivariate statistical analysis revealed seven compounds (two esters, three alcohols, and two aldehydes), which could be considered as potential marker compounds for discrimination.
Patent Dependency under European and European Union Patent Law – A Regulatory Gap
Authors: Ullrich Hanns 
Published: November 2023

Abstract
Technological progress generally is not disruptive but sequential. Innovations build on prior innovations, typically by presenting improvements or complements. Under patent law, such follow-on innovation meets with an obstacle if the use of the invention underlying it infringes a prior patent, and if, for one reason or another, the owner of that prior patent prefers, as it may, to refuse granting a license. It is only in case the follow-on (or ‘second’) invention involves an important technical advance of considerable economic significance in relation to the invention claimed in the prior (or ‘first’) patent that in Europe, in accordance with Art. 31 TRIPS, national patent laws provide for a right of the owner of the second patent to obtain, by way of a decision of the patent office or of a court, a dependency license. By contrast, the EU’s system of unitary patent protection does not provide for a dependency licensing regime. Instead, Regulation 1257/2021 on the European patent with unitary effect refers the matter to national law. This means that despite the importance of its invention the owner of a dependent patent will never obtain a mandatory license covering the Internal Market but only territorially limited national licenses for which it must apply separately in each Member State, go through multiple different procedures and comply with different national requirements. The absurdity of such hindering of follow-on innovation in the Internal Market by regulatory abstention is no less as regards national patents that the European Patent Office grants as a bundle in the form of the European patent and that are now additionally held together by the uniform infringement rules of the Unified Patent Court Agreement. After all, that category of a European patent is supposed to represent an equivalent alternative to the unitary patent and, therefore, ought to meet the same Internal Market requirements. Therefore, this study proposes to harmonize Member States’ dependency licensing regimes and to complement the system of unitary patent protection accordingly. To this end, it presents the common principles of national regimes, analyzes the particular need for and characteristics of modern mandatory licensing rules and discusses the deficits of alternative approaches that might be available under EU competition law. A particular emphasis is put on distinguishing dependency licensing from compulsory licensing in the public interest, and on the functional complementarity existing between incentivizing inventions by patent protection and stimulating follow-on innovation by mandatory licensing regimes.
Proactive Infliximab Monitoring Improves the Rates of Transmural Remission in Crohn’s Disease: A Propensity Score–Matched Analysis
Authors: Fernandes Samuel Raimundo , Bernardo Sónia , Saraiva Sofia , Rita Gonçalves Ana , Moura Santos Paula , Valente Ana , Araújo Correia Luís , Cortez-Pinto Helena , Magro Fernando 
Published: November 2023

Abstract

Background
Few patients can reach transmural remission in Crohn’s disease (CD) with currently available therapies. Proactive optimization of infliximab (IFX) based on trough levels may potentially improve these results.

Methods
Retrospective cohort study including consecutive CD patients starting treatment with IFX. Rates of transmural remission were compared between patients with and without therapeutic drug monitoring (target level: 5-7 µg/mL). A propensity score–matched analysis was performed to adjust for potential confounders.

Results
A total of 195 CD patients were included, 57.9% receiving proactive therapeutic drug monitoring. The rates of transmural remission were higher in patients under proactive therapeutic drug monitoring (37.2% vs 18.3%; P = .004) with similar results in the propensity score–matched analysis (34.2% vs 17.1%; P = .025). In multivariate analysis, proactive therapeutic drug monitoring was independently associated with transmural remission (odds ratio, 2.95; 95% confidence interval, 1.44-6.06; P = .003).

Conclusions
Proactive optimization of IFX based on trough levels increases the rates of transmural remission in CD.
Bayesian interpretation of non-inferiority in transcatheter versus surgical aortic valve replacement trials: a systematic review and meta-analysis
Authors: Heuts Samuel , Kawczynski Michal J , Sardari Nia Peyman , Maessen Jos G , Biondi-Zoccai Giuseppe , Gabrio Andrea 
Published: November 2023

Abstract

OBJECTIVES
The concept of non-inferiority is widely adopted in randomized trials comparing transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). However, uncertainty exists regarding the long-term outcomes of TAVR, and non-inferiority may be difficult to assess. We performed a systematic review and meta-analysis of randomized trials comparing TAVR and SAVR, with a specific emphasis on the non-inferiority margin for 5-year all-cause mortality.

METHODS
A systematic search was applied to 3 electronic databases. Randomized trials comparing TAVR and SAVR were included. Bayesian methods were implemented to evaluate the posterior probability of non-inferiority at different trial non-inferiority margins under either a vague, Cauchy, or a literature-based prior. Primary outcomes were 5-year actuarial all-cause mortality, and the probability of non-inferiority at various transformed trial non-inferiority margins. Secondary outcomes were long-term survival and 1- and 2-year actuarial survival.

RESULTS
Eight trials (n = 8698 patients) were included. Kaplan–Meier-derived 5-year survival was 61.6% (95% CI 59.8–63.5%) for TAVR, and 63.7% (95% CI 61.9–65.6%) for SAVR. Six trials (n = 6370 patients) reported all-cause mortality at 5-year follow-up. Under a vague prior, the posterior median relative risk for all-cause mortality of TAVR was 1.14, compared to SAVR (95% credible interval 1.06–1.22, probability of relative risk &lt;1.00 = 0.01%, I2 = 0%). Similar results in terms of point estimate and uncertainty measures were obtained using frequentist methods. Based on the various trial non-inferiority margins, the results of the analysis suggest that non-inferiority at 5 years is no longer likely.

CONCLUSIONS
It is unlikely that TAVR is still non-inferior to SAVR at 5 years in terms of all-cause mortality.
Monitoring for adverse drug events of high-risk medications with a computerized clinical decision support system: a prospective cohort study
Authors: Nezu Mari , Sakuma Mio , Nakamura Tsukasa , Sonoyama Tomohiro , Matsumoto Chisa , Takeuchi Jiro , Ohta Yoshinori , Kosaka Shinji , Morimoto Takeshi 
Published: November 2023

Abstract
Monitoring is recommended to prevent severe adverse drug events, but such examinations are often missed. To increase the number of monitoring that should be ordered for high-risk medications, we introduced a clinical decision support system (CDSS) that alerts and orders the monitoring for high-risk medications in an outpatient setting. We conducted a 2-year prospective cohort study at a tertiary care teaching hospital before (phase 1) and after (phase 2) the activation of a CDSS. The CDSS automatically provided alerts for liver function tests for vildagliptin, thyroid function tests for immune checkpoint inhibitors (ICIs) and multikinase inhibitors (MKIs), and a slit-lamp examination of the eyes for oral amiodarone when outpatients were prescribed the medications but not examined for a fixed period. The order of laboratory tests automatically appeared if alert was accepted. The alerts were hidden and did not appear on the display before activation of the CDSS. The outcomes were the number of prescriptions with alerts and examinations. During the study period, 330 patients in phase 1 and 307 patients in phase 2 were prescribed vildagliptin, 20 patients in phase 1 and 19 patients in phase 2 were prescribed ICIs or MKIs, and 72 patients in phase 1 and 66 patients in phase 2 were prescribed oral amiodarone. The baseline characteristics were similar between the phases. In patients prescribed vildagliptin, the proportion of alerts decreased significantly (38% vs 27%, P &lt; 0.0001), and the proportion of examinations increased significantly (0.9% vs 4.0%, P &lt; 0.0001) after activation of the CDSS. In patients prescribed ICIs or MKIs, the proportion of alerts decreased significantly (43% vs 11%, P &lt; 0.0001), and the proportion of examinations increased numerically, but not significantly (2.6% vs 7.0%, P = 0.13). In patients prescribed oral amiodarone, the proportion of alerts decreased (86% vs 81%, P = 0.055), and the proportion of examinations increased (2.2% and 3.0%, P = 0.47); neither was significant. The CDSS has potential to increase the monitoring for high-risk medications. Our study also highlighted the limited acceptance rate of monitoring by CDSS. Further studies are needed to explore the generalizability to other medications and the cause of the limited acceptance rates among physicians.
The role of inbreeding depression on productive performance in the Italian Holstein breed
Authors: Ablondi Michela , Summer Andrea , Stocco Giorgia , Finocchiaro Raffaella , van Kaam Jan-Thijs , Cassandro Martino , Dadousis Christos , Sabbioni Alberto , Cipolat-Gotet Claudio 
Published: November 2023

Abstract
Inbreeding depression has become an urgent issue in cosmopolitan breeds where the massive genetic progress achieved in the latest generations is counterbalanced by a dramatic loss of genetic diversity causing increased health issues. Thus, the aim of this study was to estimate inbreeding depression on productive traits in Holstein dairy cattle. More precisely, we aimed to i) determine the level of inbreeding in 27,735 Italian Holstein dairy cows using pedigree and genotype data, ii) quantify the effect of inbreeding on 305-d in milk yield (MY; kg), fat yield (FY; kg), and protein yield (PY; kg) based on different statistical approaches, iii) determine if recent inbreeding has a more harmful impact than ancestral ones, and iv) quantify chromosomal homozygosity effect on productive traits. Quality control was performed on the autosomal chromosomes resulting in a final dataset of 84,443 single nucleotide polymorphisms. Four statistical models were used to evaluate the presence of inbreeding depression, which included linear regression analysis and division of FPED and FROH into percentile classes. Moreover, FROH was partitioned into i) length classes to assess the role of recent and ancestral inbreeding and ii) chromosome-specific contributions (FROH-CHR). Results evidenced that inbreeding negatively impacted the productive performance of Italian Holstein Friesian cows. However, differences between the estimated FPED and FROH coefficients resulted in different estimates of inbreeding depression. For instance, a 1% increase in FPED and FROH was associated with a decrease in MY of about 44 and 61 kg (P &lt; 0.01). Further, when considering the extreme inbreeding percentile classes moving from the 5th lowest to the 95th highest, there was a reduction of −263 kg and −561 kg per lactation for FPED and FROH. Increased inbreeding, estimated by FPED and FROH, had also a negative effect on PY and FY, either fit as a regressor or percentile classes. When evaluating the impact of inbreeding based on runs of homozygosity (ROH) length classes, longer ROH (over 8 Mb) had a negative effect in all traits, indicating that recent inbreeding might be more harmful than the ancestral one. Finally, results within chromosome homozygosity highlighted specific chromosomes with a more deleterious effect on productive traits.
Oral toxicity of an artificial sweetener sucralose on the German cockroach (Blattodea: Ectobiidae) and its impact on water balance and gut microbiome
Authors: Lee Shao-Hung , Choe Dong-Hwan , Rust Michael K , Lee Chow-Yang 
Published: November 2023

Abstract
Artificial or non-nutritive sweeteners are indigestible by most animals. Some sweeteners are orally toxic to insects and have received recent interest as potential safe insecticides due to their low mammalian toxicity. In this study, we investigated the oral toxicity of sucralose on insecticide-susceptible and resistant German cockroaches, Blattella germanica (L.). In a nonchoice test, we evaluated 5, 10, and 20% sucralose solutions. Depending on the cockroach strains, mean mortality ranged from 62.5 to 92.5%, 15 to 55%, and 2.5 to 27.5% for 20, 10, and 5% sucralose, respectively. Next, we measured the impact of a 20% sucralose treatment on water loss rates in the cockroach strains. All strains lost 23.0–30.29% of body water by 6 d. Dehydrated cockroaches were more prone to be killed by sucralose than nondehydrated ones. Lastly, we evaluated the effect of 20% sucralose treatment on gut bacterial composition and found the diversity of gut bacteria in treated cockroaches was significantly reduced after 3 days, implicating a rapid change in the alimentary environment.