bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autoportrait du réel Place et fonction de la littérature dans la philosophie de Clément Rosset
Authors: Dubouclez Olivier 
Published: October 2023

La littérature occupe une place essentielle chez Rosset, non pas comme simple illustration de thèses philosophiques, mais comme expression du tragique. Cet article prend son point de départ dans l’aporie du philosopher exposée dans la Logique du pire (1971) et tente de montrer comment la littérature accomplit un geste de pensée, de « dénaturation » et de venue au tragique, bien distinct du geste philosophique. Il suggère ensuite que, de Logique du pire au Réel et son double (1976), la fonction et la place de la littérature ne sont plus tout à fait les mêmes, avant que Le Réel. Traité de l’idiotie (1977) n’explicite le statut aporétique de l’écriture littéraire. On rappelle alors que pour Rosset il y a littérature (moderne) et littérature (oraculaire) et que la question se pose de savoir si la littérature peut dire le réel, que ce soit par le moyen du double ou en se passant de toute duplication. Le cas Shakespeare permet d’envisager la notion problématique d’un réalisme littéraire conçu comme un autoportrait du réel.
L’identité de l’objet singulier : Rosset, Benoist et le réalisme des objets
Authors: Gabaret Jim 
Published: October 2023

Clément Rosset critique dans L’Objet singulier la généralité de nos représentations du réel, qui en manqueraient la singularité en projetant sur ses objets d’illusoires identités. Il risque alors un ineffabilisme insatisfaisant dans lequel tombent encore beaucoup de réalistes directs contemporains. Mais on peut confronter ces vues à ce qu’affirme au contraire Jocelyn Benoist dans Concepts de l’adéquation de nos représentations à la singularité du réel. On en gardera la saine prudence sceptique face aux tentations de beaucoup de « nouveaux réalistes » contemporains de brouiller les différences entre l’intentionnel et le réel, sans faire de l’écart entre ces deux niveaux un fossé pour la connaissance.
Le réel est-il soluble dans l’inconcevable ? Caractérisations ontologique, épistémique et doxastique du réel chez Clément Rosset
Authors: Erdrich Nicolas 
Published: October 2023

Un enjeu important qui apparaît dans tout réalisme est de parvenir à articuler une pensée du réel selon trois types de rapportsmétaphysique épistémique et doxastique Soucieuse de rendre compte de ces trois rapports en maintenant son originalité propre consistant à opposer le réel aux doubles de remplacement la théorie ontologique de Rosset a pris la forme d’un ensemble de principes qui ont évolué au cours de ses travaux Dans cet article je me propose de retracer cette évolution et d’en faire l’examen critique (section 1) Ensuite il s’agira de discuter des objections d’incohérence adressées à l’ontologie de Rosset (section 2) et enfin de situer la question des doubles de proximité par rapport à celle de la fiction (section 3) Dans la section 4 je compare le fonctionnement des doubles de remplacement avec celui de la croyance feinte Ma conclusion consiste à insister sur l’importance de maintenir une philosophie du double qui d’une part affirme l’authenticité du réel autrement dit conteste à la fois l’antiréalisme et l’irréalisme ontologiques et qui d’autre part récuse la teneur ontologique des doubles Il n’y a pas de doubles ontologiques pas même les doubles de proximité mais seulement des doubles épistémiques.
Short-term Clinical Outcomes of Ticagrelor versus Clopidogrel after Percutaneous Coronary Intervention in Patients with Myocardial Infarction: A Randomized Clinical Trial Study
Authors: Nikfarjam Salman , Borghei Yasaman , Salari Arsalan , Miraftabi Seyyed Mehrad , Gholami-Chaboki Bahare , Fakhr-Moosavi Seyyed Aboozar 
Published: October 2023

Abstract

Background:
Reperfusion can be done through primary percutaneous coronary intervention (PPCI) and thrombolytic administration. Patients with myocardial infarction should receive antiplatelet drugs from the P2Y12 receptor inhibitor category (such as ticagrelor, prasugrel, and clopidogrel). Based on recent researches, effectiveness of ticagrelor versus clopidogrel is still debatable.

Methods:
A total of 128 patients who underwent PPCI, divided into two groups (Zyllt® group (600 mg received as a loading dose, maintenance with dose of 75 mg daily)) and Ticora® group (180 mg as a loading dose, maintenance with dose of 90 mg twice). Both the groups received aspirin 80 mg daily, too. They were followed up after 3 months.

Results:
In this study, 86.9% were men, and there was no significant difference in terms of gender and age in 2 groups. Risk factors, type of myocardial infraction (MI), number of involved and infarct-related arteries, and presence of complications and their type were not statistically different in groups (P > 0.05). Among all complications, only one person had dyspnea in the Ticora group, one patient in the Ticora group, and 3 patients in the Zyllt group had chest pain. The difference in “TIMI Score” during Time was significant (P = 0.037).

Conclusion:
Our study shows no difference between ticagrelor and clopidogrel after PPCI in patients with MI in terms of risk factors, type of MI, number of involved and infarct-related arteries, and presence of complications and their type, in two studied groups.
Predictions of Adherence to Treatment in Patients Referred to the Heart Failure Clinic of Shahid Rajaee Hospital in Tehran
Authors: Shojaee Asma , Azimi Amir Vahedian , Naderi Nasim , Salaree Mohammad Mehdi , Faizi Fakhrudin 
Published: October 2023

Background:
The objective of this study was to identify the level of treatment adherence and also sought to explore several demographic, clinical, comorbidities, and self-care behavior factors that may affect adherence among patients with heart failure (HF).

Materials and Methods:
This single-center cross-sectional, questionnaire-based study was conducted on 500 adult HF patients referred to the clinic of Rajaie Cardiovascular, Medical, and Research Center, in Tehran, Iran, from February to July 2022. The level of treatment adherence was assessment through Modanloo’s questionnaire. An unadjusted and adjusted binary logistic regression model was used to check the effect of different factors on the patients’ adherence level.

Results:
Among 474 responders, 51.7% had “good” adherence to treatment. According to the results, age >54 years (odds ratio [OR]: 0.967, 95% confidence interval [CI]: 0.946–0.988, P = 0.002), mitral valve regurgitation (OR: 0.597, 95% CI: 0.362–0.982, P = 0.042) and HF duration (OR: 0.486, 95% CI: 0.274–0.862, P = 0.014) were found as independent variables associated with “poor” treatment adherence. However, higher educational level (OR: 3.313, 95% CI: 2.632–4.067, P < 0.001), New York Heart Association class I (OR: 3.231, 95% CI: 1.587–4.661, P = 0.002), ejection fraction (EF) >40% (OR: 1.023, 95% CI: 1.005–1.041, P = 0.013), HF with preserved EF (OR: 2.728, 95% CI: 1.387–5.365, P = 0.004), familiar with social media (OR: 3.792, 95% CI: 1.777–4.268, P < 0.001) and high awareness of HF (OR: 2.385, 95% CI: 1.072–3.044, P = 0.006) were significant positive predictors for good adherence to treatment.

Conclusion:
Adherence to the treatment regimen has improved compared to previous studies, but is still suboptimal, particularly with respect to awareness of HF. Therefore, improving the awareness of patients as well as encouraging and supporting them for self-care behaviors can have a positive effect on treatment adherence.
Establishment of a Two-stage Limb Ischemia in Diabetic Rats
Authors: Cao Yu , Hu Shuyu , Wang Hongbo , Li Xiaoyao , Ma Jun , Wang Liangrong 
Published: October 2023

Abstract

Background:
This study aimed to establish a clinically relevant animal model for peripheral arterial disease (PAD) that better replicates the complexity observed in human patients.

Materials and Methods:
Thirty male rats were randomly assigned into the sham (SM), femoral artery resection (FE), constrictor-induced ischemia (CI), two-stage ischemia (TS), or diabetic two-stage ischemia (DT) groups. In the FE group, rats underwent femoral artery resection, whereas the SM group had sham surgery. The CI group received progressive ischemia using two ameroid constrictors, and the TS and DT groups underwent a two-stage ischemia procedure involving initial gradual narrowing with two ameroid constrictors and subsequent femoral artery resection in healthy and diabetic rats, respectively. Perfusion evaluation and functional assessment were conducted at postoperative days 14, 28, and 42. On day 42, hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) protein expression were measured, along with histological examination and immunofluorescence analysis.

Results:
Motor function deficits and reduced limb reperfusion were most prominent in the TS and DT groups on days 28 and 42 (P < 0.05), exacerbated by type 2 diabetes. Gastrocnemius exhibited upregulated HIF-1α and VEGF protein expression, as well as increased capillary density in response to ischemia. However, the DT group showed significantly lower protein expression and capillary density, along with more severe structural damage compared to other groups (P < 0.05).

Conclusion:
A clinically relevant rat model of PAD was established by implementing a two-stage ischemia procedure involving initial progressive narrowing and subsequent femoral artery excision in the context of diabetes.
Optimisation of seed oil and powder of Momordica charantia in the formulation of body scrub cream
Authors: Winarti Lina , Dzakkiyah Shifwatu , Irawan Eka Deddy , Narulita Erlia 
Published: October 2023

Background: Momordica charantia seed oil and powder are potential ingredients for a body scrub. The seeds contain fatty acids to moisturise the skin, and the mineral content to remove dead skin cells and nourish the skin.
Objective: To determine the optimal efficiency of Momordica charantia seed oil and powder on body scrub cream produce.
Methods: The body scrub used W/O (water-in-Oil) cream base. Simplex Lattice Design was used to determine five formulas. The irritation test with the Draize Skin Test method was carried out on rats (n = three, in each formula), and the Primary Dermal Irritation Index (PDII) was calculated. Informed consent from the female participants has been obtained for the hedonic test.
Results: The body scrub cream produced appropriate organoleptic, was not irritating, and was stable after centrifugation and cycling test. The optimum formula contained five grams of oil and one gram of powder with a pH of 5.21; viscosity of 205.33 dPa.s; spreading of 6.12cm; adhesion time of 19.86 seconds; rate of washing of 20.60 seconds; a colour value of 4.04; scent value of 2.90; and texture value of 2.98.
Conclusion: The optimised body scrub cream yielded a good formula which can be developed as a body scrub preparation.
The impact of mHealth application on improving medication adherence and hypertension management: A systematic review of randomised trials
Authors: Susanto Yugo , Pristianty Liza , Hermansyah Andi 
Published: October 2023

Background: The mobile health (mHealth) application has been used for treating hypertension. However, its effectiveness in enhancing adherence and clinical outcomes in hypertensive patients remains limited.
Objective: This study aimed to determine the impact of mHealth apps on medication adherence and reduced blood pressure among hypertensive patients.
Method: A systematic review of randomised controlled trials published in Scopus, PubMed, and ScienceDirect from 2008 to 2022 was conducted. Bibliographies of eligible articles were further reviewed.
Result: A total of 289 articles were identified, and 24 articles were qualified for inclusion. The mHealth apps improved either medication adherence or reduced blood pressure in seven studies (29%). Eleven studies (46%) showed that it could both increase medication adherence and lower blood pressure significantly. Six studies (25%) reported no improvement in both outcomes.
Conclusion: There is a piece of evidence that mHealth apps can improve medication adherence and accordingly reduce blood pressure.
Characteristics and communication skills of health professionals in implementing provider-initiated HIV testing and counselling (PITC) for Indonesian pregnant women
Authors: Hikmah Faiqatul , Notobroto Hari Basuki , Devy Shrimarti Rukmini , Triyono Erwin Astha 
Published: October 2023

Background: HIV testing for pregnant women is an important test during pregnancy. HIV testing for pregnant women is a way to prevent mother-to-child HIV transmission.
Objectives: To investigate the relationship between the characteristics and communication skills of health professionals while conducting provider-initiated HIV testing and counselling (PITC) for pregnant women.
Methods: This was an observational study with a cross-sectional approach. The study was conducted at 23 public health centres with 80 health professionals who conduct PITC. The data was analysed using the Chi-Square test.
Results: There was a correlation between the characteristics and communication skills of respondents. Relationships were observed between respondents trained on PITC and communication with patients during PITC sessions (p=0.002); work experience and non-verbal communication skills (p=0.047), and type of profession of respondents and non-verbal communication skills (p=0.029).
Conclusions: Communication skills had a relationship with experienced training on PITC, work experience, and type of profession. Increasing the communication skill of health professionals through work experience and training or education to improve the ability of health professionals in PITC services.
Therapy pattern of bronchodilators in chronic obstructive pulmonary disease (COPD) patients with acute exacerbations
Authors: Samirah Samirah , Aryani Toetik , Puspitasari Arina Dery , Ibrahim Marisa Anggia , Lutfiyah Bunga Izzatul , Rasyid Alfian Nur 
Published: October 2023

Background: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is a worsening condition of acute respiratory symptoms caused by microbial infection, increased air pollution, and fatigue.
Objective: This study determines the pattern of bronchodilators in patients with acute exacerbations of COPD.
Method: This study was observational, using the health medical records of patients with COPD at the Universitas Airlangga Hospital, Surabaya. It was conducted between January-December 2019 on male patients who received bronchodilator therapy until discharge and were from age 40 and older.
Result: A total of 48 patients met the inclusion criteria. The most commonly used bronchodilator therapy for inpatients was the combination of ipratropium bromide/salbutamol sulfate 0.5 mg/2.5 mg through inhalation in 63.64%. The most frequently used bronchodilator for discharge was salbutamol sulfate 2-4 mg orally in 87.50%.
Conclusion: Therapy for acute exacerbation of COPD using a combination of ipratropium bromide/salbutamol sulfate as a preventive therapy is in line with the GOLD guidelines.
Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride
Authors: Sari Lusia Oktora Ruma Kumala , Fardliana Lintang Qonita , Nurahmanto Dwi , Irawan Eka Deddy 
Published: October 2023

Background: Ciprofloxacin hydrochloride (CH) is an antibiotic used to treat urinary tract infections. CH has a short half-life and low bioavailability. Microspheres combined with a mucoadhesive system can increase the residence time of the drug in the stomach to increase the bioavailability of CH.
Objective: This research was conducted to obtain the best amount of carbomer as a polymer mucoadhesive and ethyl cellulose as a matrix polymer based on factorial design.
Method: The factorial design 22 was used to determine the amount of carbomer and ethyl cellulose to produce optimum mucoadhesive microspheres. Three responses were observed in this study: particle size, entrapment efficiency, and mucoadhesive strength.
Result: The resulting entrapment efficiency was 69.0%, particle size was 404.52 nm, and mucoadhesive strength was 64.3 grams, with drug loading and yield values of 19.13% and 99.8%, respectively.
Conclusion: The optimum formula with the highest response value is the formula containing 300 mg carbomer and 1000 mg ethyl cellulose.
Pharmacists' perception about design and content of medicine labels on prescription services in community pharmacies
Authors: Mufarrihah  , Yaniar Nur Hidayah  , Arie Sulistyarini  , Ana Yuda  
Published: October 2023

Background: Differences in perception among pharmacists and the absence of standards or regulations for labelling prescribed medicines in Indonesia make the labels patients receive have different designs and contents. Incomplete information and insufficient medicine label design can lead to medication errors.
Objective: This study aimed to determine the pharmacists’ perception of the design and content of prescribed medicine labels.
Method: This study was conducted by survey using an online questionnaire developed based on the "FIP Guidelines for The Labels of Prescribed Medicines" and Regulation of the Minister of Health of the Republic of Indonesia number. 73 the year 2016 concerning Pharmaceutical Service Standards in Pharmacies. Questionnaires were distributed through personal chat and social media groups of community pharmacists.
Result: A total of 925 pharmacists from 32 provinces of Indonesia participated in this study. Respondents considered the most important information on the label of prescribed drugs namely instructions for drug use (84.6%), patient name (81.6%), pharmacy name (76.1%), special instructions (71.5%), and pharmacist name (63.9%). For the label’s design, most respondents preferred printed and handwritten labels (61.2%).
Conclusion: It can be concluded that different pharmacists' perceptions affect the labelling of prescribed medicines. There is a need for regulations or standards of labelling prescribed medicines.
Fungsi Dewan Keamanan PBB Dalam Penyelesaian Konflik Bersenjata Internasional
Authors: Marasabessy Maryam , Hanafi Irma Halimah , Wattimena Josiana Agusthina Yvonne 
Published: October 2023

Introduction: This study discusses the function of the UN Security Council in resolving international armed conflicts which have a very large role in fighting for and providing maintenance of world peace and security. The UN Security Council has a very large role in being a peacekeeper to stabilize conflicts related to information such as human rights, disarmament, gender, humanitarian relations and political affairs. The implementation of international law provisions in the UN Charter has not been carried out optimally because there are still countries that do not comply with the rules that have been set. Purposes of the Research: This study aims to identify and examine the functions of the Security Council in the structure of the UN international organization and to identify and examine the functions of the UN Security Council in resolving international conflicts according to the UN charter.Methods of the Research: The research method used is normative juridical research. This research is called library research because normative juridical research is carried out by examining sources of legal material using a law approach and a case approach. The use of legal material sources consists of primary, secondary and tertiary legal materials. The technique of collecting this research was done through library technique.Results of the Research: The United Nations Security Council as one of the main organs in the United Nations has functions and powers which are generally regulated in Articles 24 to 26 of the United Nations Charter which includes members of the United Nations giving the Security Council the main responsibility for maintaining international peace and security as well as having the responsibility in formulating plans to be submitted to members of the United Nations for the establishment of a system of arms regulation. In the conflict in Central Africa, the implementation of these provisions has not been carried out optimally because there are still violations by several parties by not complying with the policies issued by the Security Council. It requires the commitment of all disputing parties to comply with the applicable provisions of Humanitarian Law and provide strict sanctions against those who violate them.
Tindak Pidana Penggunaan Ganja Untuk Keperluan Pengobatan
Authors: Kaya Ronaldo Semmy , Hehanussa Deassy Jacomina Anthoneta , Latupeirissa Julianus Edwin 
Published: October 2023

Introduction: This study discusses cannabis which is used as a medicinal ingredient.Purposes of the Research: analyze adn explain the qualificationof marijuana used as a crime and analyze and explain thr policy of cannabis formulation for medicinal puerpuseMethods of the Research: This study uses a normative juridical method with the legal materials used in the study are primary, secondary and tertiary with the use of literature study techniques in the form of legal regulations, scientific papers and literatureResults of the Research: The results of the study indicate that the use of marijuana for medicinal purposes can be subject to criminal penalties as it is known that marijuana is a class I narcotic besides Article 37 of Law Number 35 of 2009 stipulates that only Narcotics Groups II and III can be used as medicinal ingredients. Furthermore, Article 53 of Law Number 35 of 2009 regulates the use of Narcotics II and III in limited quantities to be used as treatment materials. However, class I narcotics are not allowed to be used as any medication. That means those who store, distribute and use marijuana can be punished.
Cost-based Comparative Analysis of Diabetic Hand Ulcers and Diabetic Foot Ulcers
Authors: AMUTKAN ÇİÇEK Çağla 
Published: October 2023

Background:The Social Insurance Institution of Turkey reported that in 2021, there were approximately 12 million patients with diabetes under universal health insurance. and the expenditure was incurred for the treatment of complications was TL 2.6 billion.Although previous studies have analyzed the cost of diabetic foot ulcers, no study from Turkey has yet compared the costs of diabetic hand ulcers and foot ulcers and analyzed the relationship between the cost and demographic characteristics of patients.
Methods:From January 2022 to June 2022, the data of 49 patients with diabetic hand ulcers and 44 patients with diabetic foot ulcers were analyzed retrospectively according to demographic datas and costs.Correlations were analyzed using cross tables, chi-square statistics, and partial correlation analysis, and groups were compared using t-test for independent groups and covariance analysis.
Results:The calculated average cost of patients who were followed up and treated for diabetic hand and foot ulcers was 257.01 USD and 462.54 USD, respectively. There was no statistically significant difference between the patients with diabetic hand and diabetic foot ulcers in terms of mean age, length of hospital stay, or HBA1C and CRP levels at admission. The mean cost of the diabetic hand was lower than that of the diabetic foot, and this difference was statistically significant.
Conclusion:Although diabetic hand infections are less costly and cause fewer major amputations, it is a clinical condition that should be given at least as much attention as diabetic foot ulcer due to its atypical localized onset and the reproductive potential of different microorganisms.