bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital and innovative entrepreneurship in the Indian handicraft sector after the COVID-19 pandemic: challenges and opportunities
Authors: Yadav Uma Shankar , Tripathi Ravindra , Tripathi Mano Ashish , Ghosal Indrajit , Kumar Ashish , Mandal Mitu , Singh Akanksha 
Published: October 2023

AbstractThis research focuses on the factors that barriers and foster (drivers) digital innovation and entrepreneurship amongst small businesses operating in the Handicraft industry after the economic downturn. From the perspective of new Indian craft entrepreneurs, digital and innovative entrepreneurship is crucial to surviving the crisis. It will eventually encourage the development of the handmade goods market and the artisanal reconfiguration as a business. In this study, the qualitative method was used. For the creation of themes, Inductive content analysis (analytical, inductive technique) was used to interview fifty online handicraft business owners who rely on their craft talents for income. After the pandemic, two types of motivation were generated for handmade entrepreneurs. The first motivation was extrinsic, which conditioned the handicraft market, restricted mobility, and upgraded household status for entrepreneurship. The second was intrinsic motivation among the craft entrepreneurs who generated individual and professional skill growth. These two factors encouraged digital craft innovations and entrepreneurial advancement of transitioning handicraft companies to digital platforms. After the interview, respondents explained several hindrances or restrictions, market interruption, and quality internet. Even after that, it resolved as the effect of the pandemic reduced and digital skill training for innovation and entrepreneurship passion increased for developing a robust programme that supports the handicraft new entrepreneurs after the economic calamities. This finding contributes to the area of investigation and contributes to entrepreneurship literature. This study will open the route for making the policy and development of solid strategic plans for the handicraft sector’s new craft entrepreneurs. With the help of innovative and digital entrepreneurs, small-scale or craft industries will boost the Indian economy and give some of the best suggestions for global economies. For developing economies, this study will also empower entrepreneurs to open new dimensions for marketing, supply chain, and exportation and will finally increase the Globalisation of handmade products.
What should we expect when two myositis-specific antibodies coexist in a patient
Authors: Zheng Yiming , Zhao Yawen , Hao Hongjun , Wang Zhaoxia , Gao Feng , Zhang Wei , Yuan Yun 
Published: October 2023

Abstract
Background
The coexistence of two myositis-specific autoantibodies (MSA) is considered extremely rare. We describe three patients with both anti-signal recognition particle (SRP) antibodies and another MSA in serum.

Methods
We performed a retrospective clinical data collection and follow-up studies of the clinical manifestations and treatment outcome of three patients positive with anti-SRP antibodies and other MSAs. IgG antibodies against MSAs were detected using commercial line immunoblot assay.

Results
The tests of MSA showed positive result of anti-SRP antibodies and another one MSA including anti-TIF1-γ, anti-Jo1, or anti-EJ antibodies, respectively. The proximal muscle weakness appeared in 2 patients; interstitial lung disease presented in 2 patients. The serum CK level was elevated in 1 patient. The muscle biopsy showed necrotizing myopathy in 1 patient and deposition of membrane attack complex on scattered myofibers in the other one patient. One of the two patients with interstitial lung disease died because of respiratory failure. One patient had completely improved and the other one showed partial remission after immunosuppressive therapy.

Conclusions
The patients with anti-SRP antibodies co-occurred with the other MSA may have various clinical characteristics. The clinicopathological phenotypes of these patients seem to be mainly caused by one of the MSAs, namely the responsible antibody.
Reliability of point-of-care ultrasound to evaluate fluid tolerance performed by critical care residents
Authors: Guerrero-Gutiérrez Manuel A. , García-Guillén Francisco Javier , Adame-Encarnación Humberto , Monera-Martínez Fernando , Ñamendys-Silva Silvio A. , Córdova-Sánchez Bertha M. 
Published: October 2023

Abstract
Background
Patients with hypotension usually receive intravenous fluids, but only 50% will respond to fluid administration. We aimed to assess the intra and interobserver agreement to evaluate fluid tolerance through diverse ultrasonographic methods.

Methods
We prospectively included critically ill patients on mechanical ventilation. One trained intensivist and two intensive care residents obtained the left ventricular outflow tract velocity–time integral (VTI) variability, inferior vena cava (IVC) distensibility index, internal jugular vein (IJV) distensibility index, and each component of the venous excess ultrasound (VExUS) system. We obtained the intraclass correlation coefficient (ICC) and Gwet’s first-order agreement coefficient (AC1), as appropriate.

Results
We included 32 patients. In-training observers were unable to assess the VTI-variability in two patients. The interobserver agreement was moderate to evaluate the IJV-distensibility index (AC1 0.54, CI 95% 0.29–0.80), fair to evaluate VTI-variability (AC1 0.39, CI 95% 0.12–0.66), and absent to evaluate the IVC-distensibility index (AC1 0.19, CI 95% − 0.07 to 0.44). To classify patients according to their VExUS grade, the intraobserver agreement was good, and the interobserver agreement was moderate (AC1 0.52, CI 95% 0.34–0.69).

Conclusions
Point-of-care ultrasound is frequently used to support decision-making in fluid management. However, we observed that the VTI variability and IVC-distensibility index might require further training of the ultrasound operators to be clinically useful. Our findings suggest that the IJV-distensibility index and the VExUS system have acceptable reproducibility among in-training observers.
A dynamic online nomogram for predicting death in hospital after aneurysmal subarachnoid hemorrhage
Authors: Li Tian , Zhuang Dongzhou , Xiao Yong , Chen Xiaoxuan , Zhong Yuan , Ou Xurong , Peng Hui , Wang Shousen , Chen Weiqiang , Sheng Jiangtao 
Published: October 2023

Abstract
Background
This study aimed to validate the efficacy the multiplication of neutrophils and monocytes (MNM) and a novel dynamic nomogram for predicting in-hospital death in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods
Retrospective study was done on 986 patients with endovascular coiling for aSAH. Independent risk factors associated with in-hospital death were identified using both univariate and multivariate logistic regression analysis. In the development cohort, a dynamic nomogram of in-hospital deaths was introduced and made available online as a straightforward calculator. To predict the in-hospital death from the external validation cohort by nomogram, calibration analysis, decision curve analysis, and receiver operating characteristic analysis were carried out.

Results
72/687 patients (10.5%) in the development cohort and 31/299 patients (10.4%) in the validation cohort died. MNM was linked to in-hospital death in univariate and multivariate regression studies. In the development cohort, a unique nomogram demonstrated a high prediction ability for in-hospital death. According to the calibration curves, the nomogram has a reliable degree of consistency and calibration. With threshold probabilities between 10% and 90%, the nomogram’s net benefit was superior to the basic model. The MNM and nomogram also exhibited good predictive values for in-hospital death in the validation cohort.

Conclusions
MNM is a novel predictor of in-hospital mortality in patients with aSAH. For aSAH patients, a dynamic nomogram is a useful technique for predicting in-hospital death.
Strategies for supervising people with mental illnesses on probation caseloads: results from a nationwide study
Authors: Van Deinse Tonya B. , Mercier Mariah Cowell , Waters Allison K. , Disbennett Mackensie , Cuddeback Gary S. , Velázquez Tracy , Lichtman Andrea Murray , Taxman Faye 
Published: October 2023

AbstractProbation officers are tasked with supervising the largest number of people living with mental illnesses in the criminal legal system, with an estimated 16–27% of individuals on probation identified as having a mental health condition. While academic research has recently focused on building the evidence base around the prototypical model of specialty mental health probation, less focus has been directed to the individual components of specialized mental health caseloads and other strategies agencies use to supervise people with mental illnesses. More specific information about these strategies would benefit probation agencies looking to implement or enhance supervision protocols for people with mental illnesses. This article describes the results from a nationwide study examining (1) probation agencies’ mental health screening and identification methods; (2) characteristics of mental health caseloads, including eligibility criteria, officer selection, required training, and interfacing with service providers; and (3) other strategies agencies use to supervise people with mental illnesses beyond mental health caseloads. Strategies for identifying mental illnesses varied, with most agencies using risk needs assessments, self-report items asked during the intake process, or information from pre-sentencing reports. Less than a third of respondents reported using screening and assessment tools specific to mental health or having a system that tracks or “flags” mental illnesses. Results also showed wide variation in mental health training requirements for probation officers, as well as variation in the strategies used for supervising people with mental illnesses (e.g., mental health caseloads, embedded mental health services within probation, modified cognitive behavioral interventions). The wide variation in implementation of supervision strategies presents (1) an opportunity for agencies to select from a variety of strategies and tailor them to fit the needs of their local context and (2) a challenge in building the evidence base for a single strategy or set of strategies.
Contextual topic discovery using unsupervised keyphrase extraction and hierarchical semantic graph model
Authors: Du Hung , Thudumu Srikanth , Giardina Antonio , Vasa Rajesh , Mouzakis Kon , Jiang Li , Chisholm John , Bista Sanat 
Published: October 2023

AbstractRecent technological advancements have led to a significant increase in digital documents. A document’s key information is generally represented by the keyphrases that provide the abstract description contained therein. With traditional keyphrase techniques, however, it is difficult to identify relevant information based on context. Several studies in the literature have explored graph-based unsupervised keyphrase extraction techniques for automatic keyphrase extraction. However, there is only limited existing work that embeds contextual information for keyphrase extraction. To understand keyphrases, it is essential to grasp both the concept and the context of the document. Hence, a hybrid unsupervised keyphrase extraction technique is presented in this paper called ContextualRank, which embeds contextual information such as sentences and paragraphs that are relevant to keyphrases in the keyphrase extraction process. We propose a hierarchical topic modeling approach for topic discovery based on aggregating the extracted keyphrases from ContextualRank. Based on the evaluation on two short-text datasets and one long-text dataset, ContextualRank obtains remarkable improvements in performance over other baselines in the short-text datasets.
Co-creation of the Global Patient Experience Data Navigator: a multi-stakeholder initiative to ensure the patient voice is represented in health decision-making
Authors: Willgoss Tom , Escontrias Omar A. , Scrafton Carole , Oehrlein Elisabeth , Livingstone Victoria , Chaplin Fiona C. , Benivento Maddalena , Chapman Hayley , Brooke Nicholas 
Published: October 2023

Abstract
Background
Putting patients’ needs and priorities at the forefront of healthcare initiatives and medical product development is critical to achieve outcomes that matter most to patients. This relies on the integration of early, meaningful patient engagement (PE) to learn what is important to patients, and collection of representative patient experience data (PXD). The increased number of PE/PXD efforts across global regulatory, health technology assessment, and healthcare systems is an important step forward to deliver improved health outcomes for patients. However, these initiatives are fragmented and lack integration, which is necessary to maximize efforts and reduce burden on patients. To overcome these challenges, the Global Patient Experience Data Navigator has been co-created by Patient Focused Medicines Development to provide practical resources that can facilitate and optimize PXD generation, collection, analysis, and dissemination for patient benefit and aims to be applicable across all therapeutic areas for all stakeholders.

Methods
Co-creation of the Navigator took place through an iterative process of validation and formalization driven by a diverse, multi-stakeholder working group with individuals who have varying knowledge/experience in PE/PXD.

Results
A series of workshops took place to conduct a gap analysis, develop a taxonomy model, and integrate existing frameworks. The collective insights led to the development of the Navigator consisting of four specific tools in the form of downloadable templates, which can be used to: (1) prioritize outcomes that matter most to patients and their caregivers; (2) select appropriate measurement methods for these outcomes; (3) identify when and why PXD is used throughout the product development cycle for each stakeholder; (4) identify when and why PXD is used throughout the healthcare process for each stakeholder. A public consultation was carried out to collect user feedback before the Navigator was made publicly available in December 2022.

Conclusion
To our knowledge, the Global Patient Experience Data Navigator is the only publicly available toolkit developed with a multi-stakeholder and disease-agnostic approach providing taxonomically grouped resources to optimize the collection and collation of PXD for patient benefit. Future work will aim to further engage patients by adding a PE dimension to the Navigator.
Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go?
Authors: Radzina Maija , Saule Laura , Mamis Edgars , Koester Ulli , Cocolios Thomas Elias , Pajuste Elina , Kalnina Marika , Palskis Kristaps , Sawitzki Zoe , Talip Zeynep , Jensen Mikael , Duchemin Charlotte , Leufgen Kirsten , Stora Thierry 
Published: October 2023

Abstract
Background
In order to support the ongoing research across Europe to facilitate access to novel radionuclides, the PRISMAP consortium (European medical radionuclides programme) was established to offer the broadest catalog of non-conventional radionuclides for medical and translational research. The aim of this article is to introduce readers with current status of novel radionuclides in Europe.

Main body
A consortium questionnaire was disseminated through the PRISMAP consortium and user community, professional associations and preclinical/clinical end users in Europe and the current status of clinical end-users in nuclear medicine were identified. A total of 40 preclinical/clinical users institutions took part in the survey. Clinical end users currently use the following radionuclides in their studies: 177Lu, 68 Ga, 111In, 90Y, other alpha emitters, 225Ac, 64Cu and Terbium isotopes. Radionuclides that would be of interest for users within the next 2–5 years are 64Cu, Terbium radionuclide “family” and alpha emitters, such as 225Ac.

Conclusions
Thanks to a questionnaire distributed by the PRISMAP consortium, the current status and needs of clinical end-users in nuclear medicine were identified.
Are open educational resources (OER) and practices (OEP) effective in improving learning achievement? A meta-analysis and research synthesis
Authors: Tlili Ahmed , Garzón Juan , Salha Soheil , Huang Ronghuai , Xu Lin , Burgos Daniel , Denden Mouna , Farrell Orna , Farrow Robert , Bozkurt Aras , Amiel Tel , McGreal Rory , López-Serrano Aída , Wiley David 
Published: October 2023

AbstractWhile several studies have investigated the various effects of open educational resources (OER) and open educational practices (OEP), few have focused on its connection to learning achievement. The related scientific literature is divided about the effects of OER and OEP with regards to their contribution to learning achievement. To address this tension, a meta-analysis and research synthesis of 25 studies (N = 119,840 participants) was conducted to quantitatively investigate the effects of OER and OEP on students’ learning achievement. The analysis included course subject, level of education, intervention duration, sample size, geographical distribution, and research design as moderating variables of the obtained effects. The findings revealed that OER and OEP have a significant yet negligible (g = 0.07, p < 0.001) effect. Additionally, the analysis found that the obtained effect can be moderated by several variables, including course subject, level of education and geographical distribution. The study findings can help various stakeholders (e.g., educators, instructional designers or policy makers) in understanding what might hinder OER and OEP effect on learning achievement, hence accommodating better learning outcomes and more effective interventions.
The role of creatine kinase in distinguishing generalized tonic–clonic seizures from psychogenic non-epileptic seizures (PNES) and syncope: a retrospective study and meta-analysis of 1300 patients
Authors: Abdelnaby Ramy , Elgenidy Anas , Heckelmann Jan , Bedewy Mahmoud Mostafa , Shabib Ahmed Samy , Ebrahim Mohamed Ayman , Elmenawi Khaled Abdelmoneim , Maallem Imene , Youssef Merna Wagih , Attia Abdelrahman M. , Moawad Mostafa Hossam , Mohamed Khaled Ashraf , Gaballa Ahmed 
Published: October 2023

Abstract
Background/aim
As the clinical differentiation between epileptic seizures, psychogenic non-epileptic seizures (PNES), and syncope depends mainly on a detailed report of the event, which may not be available, an objective assessment of a potential biochemical analysis is needed. We aimed to investigate whether serum creatine kinase (CK) could be used to differentiate epileptic seizure from PNES and syncope and to assess the strength of evidence present.

Methods
We directed a retrospective cohort study coupled with a systematic review and meta-analysis of studies that measured CK in patients with epilepsy, PNES, syncope, and healthy controls.

Results
The cohort study, which traced 202 patients, showed that the CK level was significantly higher 48 h after the event in the epilepsy group versus patients with syncope (p < 0.01) Along with 1086 patients obtained through a database search for meta-analysis, CK level compared to different types of seizures from PNES was higher in epileptic seizure patients with a mean difference of 568.966 mIU/ml (95% CI 166.864, 971.067). The subgroup analysis of CK showed that it was higher in GTCS compared to syncope with a mean difference of 125.39 mIU/ml (95% CI 45.25, 205.52).

Discussion
Increased serum levels of CK have been associated mainly with epileptic seizures in relation to non-epileptic events. However, further studies would try to explore the variation in measurements and any other potential diagnostic marker.

Conclusion
The cohort study shows that the CK level in epilepsy seizures is higher after 48 h from the event compared to syncope. Moreover, the meta-analysis results show the present diagnostic utility of CK and its importance to be used in accordance with a detailed report of the event.
Multi-functional epoxides cross-linked collagen sponges for tissue engineering scaffolds
Authors: Zhang Yuanzhi , Yang Changkai , Gu Min , Zhang Xiaoxia , Zhang Xueqing , Li Guoying 
Published: October 2023

AbstractWith the efficient cross-linking abilities and the flexible regulation abilities to the performances of cross-linked products, the multi-functional aliphatic epoxides were once widely used to cross-link the collagen-based materials in the last century. In present work, the multi-functional epoxides were used to construct and cross-link collagen sponges for tissue engineering scaffolds, which was hoped to board the theoretical system of epoxides and explore their potentials for modern applications. The bi- to tetra-functional epoxides were used to cross-link collagen solutions and establish the gel-like precursors, then using freeze-drying to form the final sponges. The SEM observed that the sponges had shown regular porous structures with a wide range of pore sizes from 160 to 440 μm. The sponges had presented the resistance to enzymatic degradation, shape-remaining ability, and reversible compressibility in aqueous environments, which all could be regulated through the functionalities of epoxides. The regulation abilities of multi-functional epoxides on the performances of sponges had been mainly achieved through the cross-linking degrees that the higher functionality of epoxides would bring higher cross-linking degree. Such higher cross-linking degrees could enhance the elastic behaviors of gel-like precursors, and improve the compressive strengths and thermal stabilities of sponges. Nevertheless, the multi-functional epoxides had barely affected the safety of collagen sponges at the cellular level according to the results of CCK8 assay and the SEM and CLSM images of L929 fibroblasts cultured on the cross-sections of sponges.
Graphical abstract
Can introduction of sleep hygiene videos improve sleep and concentration in 5th and 6th graders? Interventional study
Authors: Hassanin Eman , Peters Shelbea , Rotimi Folasade 
Published: October 2023

Abstract
Background
Insomnia is a very common condition in childhood with a prevalence of 25–50%. It can present as difficulty with initiating and maintaining sleep with frequent disruptions throughout the night. Sleep insomnia is known to affect children’s development and contribute to poor attention and memory. Establishing a good sleep routine will have a beneficial effect not just on the child’s wellbeing and development but the whole family.
The objective of the study was to assess the effectiveness of sleep hygiene videos in improving sleep quality and subsequent cognitive function in children aged 10–11 years.
Two cartoon videos on sleep hygiene were designed along with a child-friendly questionnaire to be filled by grade 5 and 6 students in two different schools in the city of Leeds, England. Questionnaires were filled prior to viewing the videos and 2 to 3 weeks afterward to assess response to the video contents. The videos were viewed in April and May 2022.

Results
In the East of Leeds School, 49 students participated. In the North of Leeds School, 45 students participated. Significance of outcomes were analysed using the Wilcoxon signed-rank test. In the first school, there was a significant improvement in sleep duration, sleep disturbance, sleep latency, daytime dysfunction due to sleepiness and sleep efficiency (p < 0.05). In the second school, there was a significant improvement in sleep duration, sleep disturbance and sleep latency (p < 0.05).

Conclusion
Poor sleep function is a major issue in children. The results demonstrated that the use of sleep hygiene videos can support children with sleep difficulties and help them to modify their behaviour through self-health promotion.