bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antivirulent Properties of the Adamantane Derivative 4-(Adamanthyl-1)-1-(1-Aminobutyl) Benzene Against Pseudomonas Aeruginosa
Authors: Humeniuk Nataliia , Vrynchanu Nina , Zelena Liubov , Ishchenko Liudmyla , Bukhtiarova Tetiana , Vazhnichaya Elena , Boiko Iryna 
Published: October 2023

Background. Pseudomonas aeruginosa is an opportunistic pathogen characterized by a high level of virulence and classified as a microorganism with a critical priority for the development of new antimicrobial drugs. Targeting virulence factors is one of the promising approaches in antimicrobial drug development.
Objective. Investigating the antivirulence properties of the aminoadamantane derivative 4-(adamantyl-1)-1-(1-aminobutyl)benzene against P. aeruginosa.
Methods. The minimum inhibitory concentration (MIC) of 4-(adamantyl-1)-1-(1-aminobutyl)benzene (code AM-166) against the clinical strain P. aeruginosa 449 was determined using the serial microdilution method. We conducted quantitative real-time PCR to assess the impact of AM-166 on gene expression. Additionally, we investigated the synthesis of pyocyanin, hemolytic and protease activity, as well as motility of P. aeruginosa under the influence of AM-166.
Results. The obtained data indicate that the MIC of the AM-166 compound is 100 μg/ml. When exposed to AM-166 (at 0.5 MIC), we observed a decrease in the transcriptional activity of the lasI, lasR, pqsR, aprA, exoA, and exoS genes, along with an increase in the expression of the rhlR gene. Notably, AM-166 did not alter the expression of the toxA gene. Furthermore, AM-166 increased the production of pyocyanin, had no significant effect on protease activity, and inhibited both hemolytic activity and motility in P. aeruginosa 449.
Conclusions. The adamantane derivative AM-166 disrupts the functioning of the Quorum sensing systems and pathogenicity of P. aeruginosa while also altering the expression of genes that regulate the synthesis of virulence factors.
Attitude Control of Rotary Steering Drilling Stabilized Platform Based on Improved Deep Deterministic Policy Gradient
Authors: Huo Aiqing , Zhang Kun , Zhang Shuhan 
Published: October 2023

Summary
The rotary steerable drilling system is an advanced drilling technology, with stabilized platform toolface attitude control being a critical component. Due to a multitude of downhole interference factors, coupled with nonlinearities and uncertainties, challenges arise in model establishment and attitude control. Furthermore, considering that stabilized platform toolface attitude determines the drilling direction of the entire drill bit, the effectiveness of toolface attitude control will directly impact the precision and success of drilling tool guidance. In this paper, a mathematical model and a friction model of the stabilized platform are established, and an improved deep deterministic policy gradient (I_DDPG) attitude control method is proposed to address the friction nonlinearity problem existing in the rotary steering drilling stabilized platform. A prioritized experience replay based on temporal difference (TD) error and policy gradient is introduced to improve sample usage, and high similarity samples are pruned to prevent overfitting. Furthermore, SumTree structure is adopted to sort samples for reducing computational effort, and a double critic network is used to alleviate the overestimated value. Numerical simulation results illustrate that the stabilized platform attitude control system based on I_DDPG can achieve high control accuracy with both strong anti-interference capability and good robustness.
Translation, cross cultural adaptation and validation of the pelvic girdle questionnaire for the Italian population
Authors: Manzotti Andrea , Zanini Sonia , Colaceci Sofia , Giovannini Niccolò , Asnaghi Francesca , Pollini Carola , Montani Marco , Frontani Francesco , Nespoli Antonella , Fumagalli Simona , Galeoto Giovanni 
Published: October 2023

Abstract
Background. Pelvic Girdle Questionnaire (PGQ) is a questionnaire created to assess the pregnant women which suffer for pelvic girdle pain (PGP). Using specific tools to assess the pregnant women seems necessary, considering the high prevalence of PGP in this population. The aim of this study was to translate, adapt and evaluate the statistical properties of the PGQ.
Methods. PGQ was forward translated, back translated, culturally adapted, and administered to a sample of pregnant women. The statistical properties of the scale were analysed using the Cronbach alfa for reliability, the Pearson’s correlation for the concurrent validity and the responsiveness. Responsiveness was evaluated considering the t-student on a sample which undergo a treatment.
Results. PGQ showed an excellent reliability (total score alfa=0.944), a moderate correlation with ODI for functional subscale (r=0.584) and with NPRS for symptoms subscale (r=0.585). PGQ showed a responsiveness considering the intervention group with a statistically significant p for the subscales of the PGQ.
Conclusion. The adaptation process showed that PGQ is a valid tool that could be used to assess the specific population of the pregnant women. PGQ subscales seem to be able to detect disability and symptoms disorders in Italian population as it was shown on other languages adaptation.
Simultaneous Visualization of Microscopic Conductivity and Deformation in Conductive Elastomers
Authors: Liang Xiaobin , Liu Haonan , Fujinami So , Ito Makiko , Nakajima Ken 
Published: October 2023

Abstract
Conductive elastomers are promising for a wide range of applications in many fields due to their unique mechanical and electrical properties, and an understanding of the conductive mechanisms of such materials under deformation is crucial. However, revealing the microscopic conduction mechanism of conductive elastomers has been a challenge, mainly due to the lack of characterization means available to track the electrical properties of deformable materials at the nanoscale. In this study, we developed a new method that combines in situ deformation nanomechanical atomic force microscopy (AFM) and conductive AFM to successfully and simultaneously characterize the microscopic deformation and microscopic electrical conductivity of nanofiller composite conductive elastomers. With this approach, we visualized the conductive network structure of carbon black and carbon nanotube composite conductive elastomers at the nanoscale for the first time, tracked their microscopic response under different compressive strains, and revealed the correlation between microscopic and macroscopic electrical properties. This novel method is not limited to nanofiller composite conductive elastomers, the microscopic deformation and microscopic electrical conductivity of almost all composite conductive elastomers can be characterized by this method. This technique is important for understanding the conductive mechanism of conductive elastomers and improving the design of conductive elastomers.
Morphological risk factors for ACL ruptures in skeletally immature children and adolescents – a systematic review
Authors: Voskuilen Robin , Dietvorst Martijn , Steen Marieke van der , Janssen Rob 
Published: October 2023

Abstract
Background: The incidence ACL injuries in skeletally immature patients has drastically increased over the last decades. The role of morphology of the knee is still unknown in this population. The purpose of this study was to review the literature for the influence of knee morphology on the risk of ACL injury in skeletally immature patients.
Methods: Systematic review according to PRISMA guidelines. MEDLINE, Embase and Cochrane were searched in December 2022 for studies reporting on knee morphology and ACL injury in skeletally immatures. Inclusion criteria were English or Dutch studies reporting primary ACL injuries associated with a morphological parameter in skeletally immature patients. Case control studies were included.
Results: After screening 1204 studies, a total of 16 studies were included of which parameters of 14 studies were included in the meta-analyses. These studies investigated 26 knee morphological parameters risk factors as potential risk factor for ACL injury in skeletally immatures. Meta-analyses identified a smaller notch width index (0.26 vs 0.27) steeper medial and lateral tibial slope (respectively 4.8 ° vs 3.6 ° and 4.3° vs 2.8°) and higher lateral/medial tibial slope ratio as risk factors for ACL injury in skeletally immature patients.
Conclusions: A small notch width index (NWI), steeper medial and lateral tibial slope and higher lateral/medial tibial slope ratio (LTS/MTS) were identified as a risk factors for ACL injuries. Future studies should identify the influence of growth on these risk factors and assess if these are risk factors for graft failures after ACL reconstruction.
Level of evidence: Level III
Training to act FAIR: A pre-post study on teaching FAIR guiding principles to (future) researchers in higher education.
Authors: Priess-Buchheit Julia , Hermeking Noémie , Möbius Thomas W. D. 
Published: October 2023

Abstract
Background
By supporting data management teams, promoting legal frameworks on the FAIR guiding principles, and embedding FAIR training, the scientific community tried to implement the FAIR guiding principles to foster open science in higher education since 2016. However, it still needs to be determined what strategies work and which do not in fostering open science. This article is the first step to closing this research gap by examining one strategy, the effectiveness of FAIR training in higher education.
Methods
With a pre-post test design, the study evaluates the effectiveness of FAIR training on students' scientific actions and justifications in line with FAIR guiding principles. The study also assesses the influence of university legal frameworks on students' inclination towards FAIR training. We analyze the students' response behavior with odds ratios and Pearson's -chi-square-test, with the null being that response behavior is independent of pre-and post-testing. On top of that, we observe with a volcano plot what learning factors students rate highest in FAIR training.
Results
Before FAIR training, 81.1% of students suggest scientific actions not in line with the FAIR guiding principles. However, after the training, there is a 3.75-fold increase in scientific actions that adhere to these principles. Interestingly, the training does not significantly impact how students justify FAIR actions. The study observes a positive correlation between the presence of university legal frameworks on FAIR guiding principles and students' inclination towards FAIR training. It explicates safe space, participation, motivation, usefulness, and satisfaction as the five highest-rated learning factors in FAIR training.
Conclusions
The study highlights the effectiveness of FAIR training. It underscores the training potential in driving the transition towards open science in higher education and shows how much university legal frameworks can push toward such training. Students rate FAIR training as very useful and satisfactory. Important learning factors in effective FAIR training seem to be creating a safe space, letting students contribute, and encouraging students to engage in the training. However, the study also reveals the need for further training improvement, particularly in enhancing students' ability to justify FAIR actions.
Trial registration
is not applicable as this study involves no clinical trial. The study involves an educational intervention to improve students' actions and justifications of the FAIR guiding principles in scientific research. Kiel University (Germany) collected the open data in this study between June 2019 and November 2022. The institutional research committee (Central Ethics Committee of the University of Kiel) approved all procedures performed in the data collection with the approval number ZEK-10/20.
A comparison of psychosocial interventions for children with cancer and their families in low- and middle-income versus resource-rich developing countries: a systematic review and meta-analysis protocol.
Authors: Morsi Hisham , Akhtar Tooba , Balkaya Ozge , Miller Harriet Dean , Clapsaddle Jeanine , Clark Holly 
Published: October 2023

Abstract
Objectives: The provision of psychosocial care to address stressors accompanying a cancer diagnosis is instrumental in ensuring quality adjusted survival for children with cancer. Availability and delivery of these interventions is largely unknown in low- and middle-income countries (LMICs) and in resources rich developing countries.
This systematic review and meta-analysis aims to investigate and compare the published and unpublished reports of psychosocial interventions for children with cancer and their families in LMICs and resources rich developing countries.
Results: To be included in this review, studies must explore and report the impact of a psychosocial intervention on physical, mental, psychological and / or long-term health outcomes of children with cancer, their siblings, family members and carers. The impact must be reported or quantified according to a patient and family centered theoretical framework through the patient / family surveys or self-reports.
A comprehensive systematic search of relevant databases (PubMed, PsycINFO, Medline, Cochrane, CINAHL and grey literature ProQuest databases) will be carried out using an exhaustive list of search terms to identify all related hits with no language or date restrictions. A pooled effect size will be quantified for the Meta-analysis.
This study will bridge a significant existing gap and guide relevant authorities.
Comparative Performance of Contact Plate Metod and Swab Method for Surface Microbial Contamination on Medical Fabrics
Authors: Chen Feng , Li Yaru , Wang Wanqiu , Li Juan , Wang Dong , Sun Xiaxia , Peng Yaping , Deng Jianjun 
Published: October 2023

Abstract
Background: The contact plate method is widely accepted and used in various fields where hygiene and contamination levels are crucial. Evidence regarding the applicability of the contact plate method for sampling fabric microbial contamination levels in real medical environments was limited.This study aimed to assess the applicability of the contact plate method for detecting microbial contamination on medical fabrics in a real healthcare environment, thereby providing a benchmark for fabric microbial sampling methods.
Methods: In a level three obstetrics ward of a hospital, twenty-four privacy curtains adjacent to patient beds were selected for this study. The contact plate and cotton swab method were used to collect microbial samples from the curtains on the 1st, 7th, 14th, and 28th days after they were hung. The total colony count on each curtain surface was calculated, and microbial identification was performed.
Results: After excluding the effects of time, room type, and curtain location on the detected microbial load, the linear mixed-effects model analysis showed that the contact plate method yielded lower colony counts compared to the cotton swab method (P<0.001). However, the contact plate method isolated more microbial species than the cotton swab method (P <0.001). The predominant microbial species isolated from both methods were gram-positive bacteria (78.22%), followed by fungi (14.05%). The top three detected bacteria were Staphylococcus epidermidis (24.59%), Micrococcus luteus (23.42%), and Staphylococcus hominis (21.08%). Furthermore, the microbial load on curtains in double-occupancy rooms was lower than those in triple-occupancy rooms (P = 0.021), and the microbial load on curtains near windows was lower than that near doors (P = 0.004).
Conclusion: The results showed that the contact plate sampling technique is more suitable for investigating hospital infection outbreaks and identifying specific pathogens on contaminated medical fabrics than the cotton swab method.
N-Iodopyridinium Cations: Kinetic Trapping as Sulfonate Complexes
Authors: Rissanen Kari , Puttreddy Rakesh , Kumar Parveen 
Published: October 2023

Abstract
The pursuit of N-iodopyridinium cation isolation and characterization remains a challenge. Here, we report seven N-iodopyridinium sulfonate complexes that were prepared and isolated at low temperatures and characterized by X-ray diffraction analysis. These inherently instable N-iodopyridinium cations are stabilized by an oxygen of sulfonate anions via I···O halogen bond. In these complexes, the large positive charge on iodine of the (pyridine)N+–I cation act as an electron acceptor and the sulfonate oxygen as the electron donor. These complexes are stable enough in the crystalline state, yet decompose rapidly under ambient conditions, also being unstable in solution. The (pyridine)N+–I bond lengths [2.140(3) - 2.197(2) Å] and the I···O halogen bonds [2.345(6) - 2.227(3) Å] are analogous to (imide)N–I···ˉO–N+(N-oxide) uncharged halogen-bonded complexes formed from N-haloimides and pyridine N-oxides, thus confirming the existence of elusive N-iodopyridinium cation.
Impact of Semaglutide on Osteoarthritis Risk in Obese Patients: A Retrospective Cohort Study
Authors: Baser Onur , Isenman Lauren , Baser Sefika , Samayoa Gabriela 
Published: October 2023

Abstract
Background
Osteoarthritis (OA) is a prevalent degenerative joint disorder. While the effect of obesity on OA is well documented, less is known about the effect of approved anti-obesity medications (AOM) such as semaglutide on OA.
Objective
To determine the impact of semaglutide on the risk of OA in obese patients in the United States.
Materials and Methods
We conducted a retrospective cohort study utilizing Kythera Medicare data from January 2020 to August 2022. Two cohorts of patients with obesity were identified: those taking semaglutide AOMs and those not taking any AOM. A randomly chosen 10% of identified patients who did not take AOM were included in the latter group. Patients in the AOM group had at least 1 pharmacy claim for Ozempic or Wegovy. The presence of OA was determined using diagnosis codes at outpatient and inpatient visits. Multivariate analysis was utilized to adjust for demographic variables and comorbidities.
Results
After controlling for demographic and clinical factors, the AOM cohort had a lower risk of OA than the non-AOM cohort (HR, 0.90; p < .0001).
Conclusions
The inverse effect of semaglutide usage on reduced risk of OA demonstrates that this AOM may be effective in preventing OA.
Non-specific effects of inactivated M. bovis oral and parenteral treatment in a rabbit scabies model
Authors: Casais Rosa , Iglesias Natalia , Sevilla Iker A , Garrido Joseba M , Balseiro Ana , Dominguez Mercedes , Juste Ramon A 
Published: October 2023

Abstract
Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type immune mechanism that triggered by a pathogen, protects against others. Killed vaccines have been considered not to be effective. However, field efficacy of a commercial vaccine against paratuberculosis, as well as of a recently developed M. bovis heat-inactivated vaccine (HIMB) prompted to test whether it could also induce TRAIM. To this, we used a sarcoptic mange rabbit model. Twenty four weaned rabbits were treated orally or subcutaneously with a suspension of either HIMB (10^7 UFC) or placebo. Eighty four days later the animals were challenged with approximately 5,000 S. scabiei mites on the left hind limb. Skin lesion extension was measured every two weeks until 92 days post-infection (dpi). Two animals were killed at 77 dpi because of extensive skin damage. The rest were euthanized and necropsied and the lesion area and the mite burden per squared cm were estimated. Specific humoral immune responses to S. scabiei and to M. bovis were investigated with the corresponding specific ELISA tests. Subcutaneously and orally HIMB vaccinated animals compared with placebo showed reduced lesion scores (up to 74% and 62%, respectively) and mite counts (-170% and 39%, respectively). This, together with a significant positive correlation (r = 0.6276, p = 0.0031) between tuberculosis-specific antibodies and mite count at 92 dpi supported the hypothesis of non-specific effects of killed mycobacterial vaccination. Further research is needed to better understand this mechanism to maximize cross protection.
Oral probiotics supplements participating in the ICIs included treatment for the advanced lung cancer: a prospective real-world study
Authors: Tong Liping , Wan Yuming , Shi Xiaoxiao , Liu Xianguo , Liu Zhe , Li Yuehua , Luo Deyun , Zhu Jiang , Zhang Yan 
Published: October 2023

Abstract
Objective: To evaluate the effectiveness of oral probiotic supplements in patients undergoing immune checkpoint inhibitors (ICIs) for the treatment of advanced lung cancer.
Methods: This prospective real-world study enrolled patients with advanced lung cancer who were receiving ICIs as part of their treatment. The patients were divided into two groups: Group OPS received oral probiotic supplements along with ICIs, while Group C did not. The primary endpoint was progression-free survival (PFS). The secondary outcome measure was the objective response rate (ORR).
Results: A total of 253 patients were included in the study, with 71 patients in Group OPS and 182 patients in the control group (Group C). No significant differences were observed in the median PFS between the two groups for all patients. However, for small cell lung cancer (SCLC) patients, the median PFS was significantly better in the Group OPS compared to the Group C (11.1 months vs 7.0 months, p=0.049). No significant differences were observed in median PFS for the non-small cell lung cancer (NSCLC) cohort between the two groups, but a trend towards better median PFS in Group OPS was noticed (16.5 months vs. 12.3 months, p=0.56). The overall response rate (ORR) for the entire cohort was 58.0%.
Conclusion: Oral probiotics supplements in combination with ICIs included regimen may improve the outcome in patients with advanced SCLC. The above points should be proved by further study.
Research on damage evolution and fracture prediction in hydraulic continuous rotary bending low-stress cropping
Authors: Zhong Bin , Hou Shangbu , Ye Zhenhao , Wang Yuanlong , Yu Zhengyang 
Published: October 2023

Abstract

Due to the complexity of the near-net shape forming mechanism in the low-stress cropping(LSC) process, it is a challenge to accurately predict the process of fracture separation. A shear modified GTN model is proposed to study the fracture mechanism of hydraulic continuous rotary bending low-stress cropping(HCRB-LSC), and is applied to simulate the material damage evolution and predict the fracture behaviour of HCRB-LSC. Moreover, the rationality and validity of simulation results are verified by precision cropping experiments. Combined with the proposed evaluation method and evaluation index of the cross-section, the quality of cross-section obtained by cropping is quantitatively evaluated. It is found that this cropping method could increase the accuracy of the cross-section and the efficiency of cropping, and could efficiently achieve reasonable sectional accuracy and flatness at 8mm loading position. Precise prediction of near-net-shape forming damage evolution and fracture in HCRB-LSC provides an important basis for subsequent optimization of the precision cropping process.