bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mindful practice with medical interpreters
Authors: Roman Gretchen , Yousefi-Nooraie Reza , Vermilion Paul , Cupertino Anapaula , Barnett Steven , Epstein Ronald 
Published: October 2023

IntroductionMedical interpreters experience emotional burdens from the complex demands at work. Because communication access is a social determinant of health, protecting and promoting the health of medical interpreters is critical for ensuring equitable access to care for language-minority patients. The purpose of this study was to pilot a condensed 8-h program based on Mindful Practice® in Medicine addressing the contributors to distress and psychosocial stressors faced by medical sign and spoken language interpreters.MethodsUsing a single-arm embedded QUAN(qual) mixed-methods pilot study design, weekly in-person 1-h sessions for 8 weeks involved formal and informal contemplative practice, didactic delivery of the week's theme (mindfulness, noticing, teamwork, suffering, professionalism, uncertainty, compassion, and resilience), and mindful inquiry exercises (narrative medicine, appreciative interviews, and insight dialog). Quantitative well-being outcomes (mean±SEM) were gathered via survey at pre-, post-, and 1-month post-intervention time points, compared with available norms, and evaluated for differences within subjects. Voluntary feedback about the workshop series was solicited post-intervention via a free text survey item and individual exit interviews. A thematic framework was established by way of qualitative description.ResultsSeventeen medical interpreters (46.2 ± 3.1 years old; 16 women/1 man; 8 White/9 Hispanic or Latino) participated. Overall scores for teamwork (p ≤ 0.027), coping (p ≤ 0.006), and resilience (p ≤ 0.045) increased from pre- to post-intervention and pre- to 1-month post-intervention. Non-judging as a mindfulness component increased from pre- to post-intervention (p = 0.014). Compassion satisfaction (p = 0.021) and burnout (p = 0.030) as components of professional quality of life demonstrated slightly delayed effects, improving from pre- to 1-month post-intervention. Themes such as workshop schedule, group size, group composition, interactivity, topics to be added or removed, and culture are related to the overarching topic areas of intervention logistics and content. Integration of the findings accentuated the positive impact of the intervention.DiscussionThe results of this research demonstrate that mindful practice can serve as an effective resource for medical interpreters when coping with work-related stressors. Future iterations of the mindful practice intervention will further aspire to address linguistic and cultural diversity in the study population for broader representation and subsequent generalization.
Planning and development of an antimicrobial stewardship program in penitentiary facilities: strategies to optimize therapeutic prescribing and reduce the incidence of antibiotic resistance
Authors: Mazzoleni Ludovica , Zovi Andrea , D'Angelo Cinzia , Borsino Cecilia , Cocco Nicola , Lombardo Raffella Carla , Ranieri Roberto 
Published: October 2023

IntroductionIn correctional facilities, due to the high incidence of bacterial infections, antibiotics are widely prescribed. As a result, it may occur a massive and improper use of antibiotics, which promotes the development of antibiotic-resistant bacteria. However, in literature, specific experiences, interventions or guidelines aimed to optimize their prescription within prisons are sporadic.ObjectivesIn an Italian hospital where belong patients from four penitentiary institutions, a multidisciplinary team has implemented an antimicrobial stewardship project. The aim of the project was to reduce the incidence of antibiotic resistance in penitentiary institutions by optimizing and rationalizing antibiotic prescribing.MethodsFollowing the analysis of microbiological prevalence and antibiotic consumption data within correctional facilities, the Antimicrobial Stewardship Team developed operational tools to support prison healthcare staff to manage properly antibiotic therapies.ResultsThe analysis showed a gradual increase in antibiotic resistance: in 2021 the prevalence of resistant microorganisms was 1.75%, four times higher than in 2019. In contrast, between 2019 and 2021, antibiotic consumption decreased by 24%. Based on consumption data, pharmacy has drafted an antibiotic formulary for correctional facilities, supplemented with guidelines and data sheets, and also developed a prescription form for critical antibiotics.ConclusionResults showed an increasing incidence of antibiotic resistance within prisons, highlighting the need to establish a dedicated antimicrobial stewardship program. This project may impact positively not only on prisoners, but also for the entire community, as prisons can be considered as places of health education and promotion.
In Vitro and In Vivo Effects of Synthesis Novel Phenoxyacetamide Derivatives as Potent Apoptotic Inducer against HepG2 Cells through PARP-1 Inhibition
Authors: Sayed Mai M. , Nabil Zohour I. , El-Shenawy Nahla S. , Al-Eisa Rasha A. , Nafie Mohamed S. 
Published: October 2023

To discover potential cytotoxic agents, new semi-synthetic phenoxy acetamide derivatives, compound I and compound II, were synthesized, characterized, and screened for their cytotoxic activity against breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The two compounds were more promising against HepG2 than the MCF-7 cell line according to IC50 values. When tested against the HepG2 cell line, compound I, and compound II both had significantly increased cytotoxic activity when compared to the reference medication 5-Fluorouracil (5-FU), with IC50 values of 1.43 M, 5.32 M, and 6.52 M for compound 1, 5-FU and compound II, respectively. Also, compound I displayed a degree of selectivity towards cancer cells compared to normal cells. Compound I significantly enhanced HepG2 total apoptotic cell death by about a 24.51-fold increase. According to cell cycle analysis, compound I induced the arrest of the cell cycle phases G1/S and blocked the progression of the HepG2 cells. Applying the RT-PCR technique achieved a highly significant upregulation in pro-apoptotic genes. The anti-apoptotic gene was significantly downregulated. There was an intrinsic and extrinsic pathway, but the intrinsic pathway was the dominant one. Tumor growth suppression as measured by tumor weight and volume and other hematological, biochemical, and histopathological analyses confirmed the efficacy of compound I as an anticancer agent in vivo examination. Finally, the molecular docking study revealed that compound I was properly docked inside the binding site of PARP-1 protein with stable binding energies and interactive binding modes. Therefore, compound I shows promise as a selective anti-cancer derivative for the treatment of liver cancer after more investigations and clinical studies. This selectivity is a favorable characteristic in the developing cytotoxic agents for cancer treatment, as it indicates a potential for reduced harm to health tissues.
Synthesis and Structural Insight into poly(dimethylsiloxane)-b-poly(2-vinylpyridine) Copolymers
Authors: Manesi Gkreti-Maria , Moutsios Ioannis , Moschovas Dimitrios , Papadopoulos Georgios , Ntaras Christos , Rosenthal Martin , Vidal Loic , Ageev Georgiy G. , Ivanov Dimitri A. , Avgeropoulos Apostolos 
Published: October 2023

In this study, the use of anionic polymerization for the synthesis of living poly(dimethylsiloxane) or PDMS-Li+, as well as poly(2-vinylpyridine) or P2VP-Li+ homopolymers, and the subsequent use of chlorosilane chemistry in order for the two blocks to be covalently joined leading to PDMS-b-P2VP copolymers is proposed. High vacuum manipulations enabled the synthesis of well-defined materials with different molecular weights (Μ¯n, from 9.8 to 36.0 kg/mol) and volume fraction ratios (φ, from 0.15 to 0.67). The Μ¯n values, dispersity indices, and composition were determined through membrane/vapor pressure osmometry (MO/VPO), size exclusion chromatography (SEC), and proton nuclear magnetic resonance spectroscopy (1H NMR), respectively, while the thermal transitions were determined via differential scanning calorimetry (DSC). The morphological characterization results suggested that for common composition ratios, lamellar, cylindrical, and spherical phases with domain periodicities ranging from approximately 15 to 39 nm are formed. A post-polymerization chemical modification reaction to quaternize the nitrogen atom in some of the P2VP monomeric units in the copolymer with the highest P2VP content, and the additional characterizations through 1H NMR, infrared spectroscopy, DSC, and contact angle are reported. The synthesis, characterization, and quaternization of the copolymer structure are important findings toward the preparation of functional materials with enhanced properties suitable for various nanotechnology applications.
Results of the Study of Cytogenetic and Molecular Genetic Features in Patients with Mantle Cell Lymphoma
Authors: Клеина Е.В. , Волошин С.В. , Семенова Н.Ю. , Линников С.Ю. , Немсцверидзе Н.Н. , Бакай М.П. , Смирнова А.П. , Лазарева Н.М. , Кувшинов А.Ю. , Карягина Е.В. , Успенская О.С. , Зюзгин И.С. , Сидоркевич С.В. , Мартынкевич И.С. 
Published: October 2023

Мантийноклеточная лимфома (МКЛ) – агрессивная и тяжело поддающаяся терапии лимфома из зрелых В-лимфоцитов, характеризующаяся транслокацией t(11;14) (q13;q32) и гиперэкспрессией циклина D1. У большинства пациентов заболевание отличается прогрессирующим клиническим течением, требующим незамедлительного начала противоопухолевой терапии, однако наряду с агрессивными вариантами выявляются индолентные МКЛ с длительной выживаемостью и возможностью применения тактики «наблюдай и жди». Такое различие обусловливается наличием вторичных цито- и молекулярно-цитогенетических аберраций, выявляющихся в дополнение к высокоспецифической t(11;14)(q13;q32), которые усиливают онкогенный потенциал циклина D1, вовлекают в лимфомогенез гены, регулирующие клеточный цикл, апоптоз, репарацию поврежденной ДНК, таким образом способствуя увеличению нестабильности генома и дальнейшей злокачественной трансформации опухолевого клона. В настоящее время особое внимание уделяется изучению прогностического влияния изменений кариотипа и аберраций отдельных генов, таких как MYC/8q24 и ТР53/17р13, на выживаемость пациентов с МКЛ. В нашем исследовании мы оценили генетический профиль 117 пациентов с МКЛ для выявления прогностически значимых цитогенетических и молекулярно-генетических маркеров и их взаимосвязи с продолжительностью общей и безрецидивной выживаемости пациентов.
Mantle cell lymphoma (MCL) is an aggressive and difficult to treat lymphoma of mature B-lymphocytes characterized by t(11;14)(q13;q32) translocation and overexpression of cyclin D1. In most cases, the disease is manifested by progressive use of therapy, requiring the expense of starting anticancer therapy, however, in combination with aggressive variants, indolent MCL with long-term survival and the possibility of "watch and wait" tactics are detected. This difference is due to the presence of secondary cytogenetic and molecular cytogenetic aberrations, which are revealed in addition to the highly specific translocation t(11;14)(q13;q32), which enhance the oncogenic potential of cyclin D1, involve genes that regulate the cell cycle, apoptosis, and repair in lymphomagenesis. damaged DNA, thus contributing to an increase in genome instability and further malignant transformation of the tumor clone. Currently, special attention is paid to the study of the prognostic impact of changes in the karyotype and aberrations of individual genes, such as MYC/8q24 and TP53/17p13, on the survival of patients with MCL. In our study, we assessed the genetic profile of 117 patients with MCL to identify prognostic cytogenetic and molecular genetic markers and their relationship with the duration of overall and disease-free survival of patients.
Comparison of the Effectiveness of Sleep Quality with Categories of Using and Not Using Lights while Sleeping in Students
Authors: Mulyana Hilman , Deni Wahyudi  , Yudi Supriyadi  
Published: October 2023

The prevalence of sleep quality in adolescents in Indonesia in women has a high prevalence of 71.3% compared to men, which is 66.4%. One of the factors that affect sleep quality is lamp light, the impact of poor sleep quality can cause mental and physical disturbances for someone Arief 2021. Especially for students who experience decreased concentration and morbidity at school. This study was carried out in June 2022 at Daarul Abroor Vocational School, Tasikmalaya Regency, with the aim of knowing the comparison of sleep quality using and not using light while sleeping in students. This study uses a quantitative method with a cross sectional approach with a population of 162 people. The samples taken in this study were 62 people. The number of samples is categorized by objects that use lights and do not use lights. This study uses the standard Pittsburgh Sleep Quality Index (psqi) instrument. The results of this study found that most of the students who had good sleep quality did not use lamps while sleeping as many as 14 people (45.2%), while students who used lamps when sleeping were 5 people (16.1%). Statistical analysis used in this study using the Chi-Square test and the results obtained significant differences in the quality of sleep using and not using light while sleeping in the students with (p = 0.028).
Characteristics Of Corn Drying Using Small Scale Dome Type Dryer
Authors: Kowimbin Meylan , Longdong Ireine A. , Tooy Dedie 
Published: October 2023

This study aims to measure drying temperature, relative humidity (RH), moisture content, and drying rate versus time in small-scale dome-type dryers. The results of research on drying corn using a small-scale dome-type dryer The average air temperature on the first day of the experiment was 43.7⁰C, and on the second day was 42.8⁰C. First 2 days experiment 34⁰C, the second day 37.4⁰C third day 42.1⁰C. The average air humidity on the first 1-day experiment was 38%, and the second day was 41%. On the first 2 days of the experiment, the average air humidity was 38%, on the second day was 38%, and on the third day was 36%. The water content during the drying process of corn without husks and corn husks in experiment 1 averaged the initial moisture content of corn without husks at 22.7% and corn husks at 22.5%. Experiment 2 averaged the initial moisture content of corn without husks at 29.7% and corn husks at 30.5%. Experiment 1 with a drying time of 16 hours and experiment 2 20 hours with an average final content of 13-14%. The average drying rate in experiment 1 of corn without husk was 1.46%/hour, corn with husk was 1.15%/hour, and in the second experiment the average drying rate of corn without husk was 1.08%/hour, corn with husk was 1.00%/hour.
Keywords: Corn Drying, Small Scale Dome.
Abstrak
Penelitian ini bertujuan untuk mengukur suhu pengeringan, kelembaban relative (RH), kadar air, serta laju pengeringan terhadap waktu pada alat pengering tipe dome skala kecil. Hasil dari penelitian pengeringan jagung menggunakan alat pengering tipe dome skala kecil Suhu udara alat rata-rata pada percobaan 1 hari pertama 43,7⁰C, hari kedua 42,8⁰C. Percobaan 2 hari pertama 34⁰C, hari kedua 37,4⁰C hari ketiga 42,1⁰C. Kelembaban udara rata-rata pada percobaan 1 hari pertama 38%, hari kedua 41%. Percobaan 2 hari pertama kelembaban udara rata-rata 38%, hari kedua 38%, dan hari ketiga 36%. Kadar air selama proses pengeringan jagung tanpa klobot dan jagung klobot percobaan 1 rata-rata kadar air awal jagung tanpa klobot 22,7% dan jagung klobot 22.5%. Percobaan 2 rata-rata kadar air awal jagung tanpa klobot 29,7% dan jagung klobot 30,5%. Percobaan 1 dengan lama pengeringan 16 jam dan percobaan 2 20 jam dengan rata-rata kadar akhir 13-14%. Laju pengeringan rata-rata pada percobaan 1 jagung tanpa klobot sebesar 1,46%/jam, jagung klobot 1,15%/jam, dan percobaan kedua rata-rata laju pengeringan jagung tanpa klobot yaitu 1,08%/jam, jagung klobot yaitu 1,00%/jam.

Kata Kunci : Pengeringan Jagung, Dome Skala Kecil
Pemanfaatan Teknologi Komputer untuk Pembelajaran Ilustrasi Digital pada Siswa Raudhatul Athfal Ma’had di Kota Palembang
Authors: Sanmorino Ahmad , Gustriansyah Rendra , Puspasari Shinta 
Published: October 2023

Salah satu pemanfaatan teknologi komputer di era modern saat ini adalah untuk pembelajaran ilustrasi digital. Melalui kegiatan Pelayanan kepada Masyarakat (PkM) ini penulis ingin berbagi pengetahuan mengenai pemanfaatan teknologi komputer sebagai media pembelajaran ilustrasi digital untuk siswa-siswa Raudhatul Athfal pada Ma’had di Kelurahan Talang Jambe, Kota Palembang. Tujuan yang ingin dicapai dari kegiatan PkM ini adalah menumbuhkan minat siswa Raudhatul Athfal untuk mencoba teknologi berbasis komputer sebagai media pembuatan ilustrasi digital. Metode pelaksanaan kegiatan PkM ini terdiri dari dua tahap, pertama, pemaparan cara pembuatan ilustrasi digital kepada para siswa. Kedua, membimbing para siswa untuk mencoba langsung pembuatan ilustrasi digital menggunakan perangkat komputer yang telah disediakan tim PkM. Hasil dari kegiatan PkM ini memperlihatkan besarnya minat para siswa yang tertarik untuk membuat ilustrasi digital yaitu sebesar 75 persen. Adapun persentase jumlah siswa yang ingin mencoba langsung adalah sebesar 75 persen. Sedangkan jumlah siswa yang tidak tahu atau tidak memberi tanggapan hanya sebesar 25 persen. Berdasarkan feedback hasil kegiatan PkM ini dapat dilihat secara keseluruan siswa Raudhatul Athfal memiliki ketertarikan yang besar untuk mencoba dan menggunakan teknologi berbasis komputer sebagai media pembuatan ilustrasi digital.
Utilization of Computer Technology for Digital Illustration Learning for Raudhatul Athfal Students in Palembang City
One of the uses of computer technology in the modern era is for learning digital illustrations. Through this Community Service (PkM) activity, the author wants to share knowledge about the use of computer technology as a digital illustration learning medium for Raudhatul Athfal students at Ma'had in Talang Jambe Village, Palembang City. The goal to be achieved of this PkM activity is to foster the interest of Raudhatul Athfal students to try computer-based technology as a medium for making digital illustrations. The method for implementing this PkM activity consists of two stages, first, explaining how to make digital illustrations to students, second, guiding students to try directly making digital illustrations using computer apps that have been provided by the PkM team. The results of this PkM activity show the high interest of students who are interested in making digital illustrations, namely 75 percent. The percentage of students who want to try directly is 75 percent. Meanwhile, the number of students who did not know or did not respond was only 25 percent. Based on the feedback on the results of this PkM activity, it shows that as a whole Raudhatul Athfal's students have a great interest in trying and using computer-based technology as a medium for making digital illustrations.
Pelatihan Social Media Marketing pada Pelaku UMKM di Desa Semanding
Authors: Dewi Hapsari Shinta Citra Puspita , Prabayanti Herma Retno , Pembayun Nur Shanti Retno , Erta Erta 
Published: October 2023

UMKM memiliki peran yang signifikan terhadap pertumbuhan ekonomi negara. Tingginya jumlah UMKM di Indonesia tidak terlepas dari berbagai tantangan serta kondisi pandemi Covid-19 yang mendorong perubahan pada pola konsumsi barang dan jasa menjadi momentum untuk mengakselerasi transformasi digital. Globalisasi dan pasar bebas menjadi tantangan bagi Usaha Kecil dan Menengah (UKM) untuk terus bertahan. Salah satu potensi yang dapat dimanfaatkan adalah potensi teknologi informasi. Tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan pelatihan kepada pelaku UMKM tentang bagaimana memasarkan produk melalui social media. Metode pelaksanaan kegiatan ini terdiri dari empat tahapan yaitu persiapan, survey, pelaksanaan, dan evaluasi. Data hasil kegiatan dianalisis secara deskriptif berdasarkan hasil penilaian langsung oleh tim pelaksana setelah sesi pelatihan/penyampaian materi dilaksanakan pada 20 pelaku UMKM yang terlibat dalam kegiatan ini. Hasil kegiatan pengabdian masyarakat ini menunjukkan pelaku UMKM mampu membuat akun social media memasarkan produknya lebih luas. Kegiatan pengabdian kepada masyarakat ini diharapkan mampu meningkatkan pengetahuan dan keterampilan pelaku UMKM melalui pemanfaatan e-commerce dan social media dengan memperluas akses pasar.
Social Media Marketing Training for SMEs in Semanding Village
Abstract
SMEs play a significant role in the country's economic growth. The high number of SMEs in Indonesia is attributed to various challenges and the Covid-19 pandemic situation, which has driven changes in the consumption patterns of goods and services, becoming an opportunity to accelerate digital transformation. Globalization and free markets present challenges for Small and Medium Enterprises (SMEs) to sustain themselves. One potential aspect that can be utilized is information technology. The objective of this community service activity is to provide training to SME practitioners on marketing products through social media. The implementation method of this activity consists of four stages: preparation, survey, implementation, and evaluation. Data from the activity were analyzed descriptively based on direct assessments by the implementation team after the training/material delivery sessions, involving 20 SME practitioners participating in this activity. The results of this community service activity indicate that SME practitioners were able to create social media accounts to market their products more extensively. This community service activity is expected to enhance the knowledge and skills of SME practitioners in utilizing e-commerce and social media to expand market access.