bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legalisasi Aset Dalam Reforma Agraria (Studi Kasus: Di Kabupaten Rejang Lebong)
Authors: Sudjito Sudjito , Saputra Nanda 
Published: January 2024

Penelitian ini dimaksudkan untuk mengetahui tentang: 1. Legalisasi asset dalam Reforma Agraria di Kabupaten Rejang Lebong; 2. Petani peserta legalisasi asset dalam Reforma Agraria di Kabupaten Rejang Lebong; dan 3. Faktor-faktor yang mempengaruhi legalisasi asset dalam Reforma Agraria di Kabpaten Rejang Lebong.
Metode penelitian yang digunakan adalah yuridis-normatif. Data yang dikumpulkan, diolah, dan dinalisis sebatas data sekunder, berasal dari dokumen-dokumen, arsip, dan sumber lain yang tersedia di Kantor Pertanahan Kabupaten Rejang Lebong. Kesimpulan ditarik secara induktif.
Hasil penelitian menujukkan antara lain: 1. Objek legalisasi asset dalam Reforma Agraria adalah tanah Negara eks HGU PT. Bumi Mitra Sentosa yang telah diterlantarkan; 2. Peserta legalisasi asset dalam Reforma Agraria adalah petani yang resmi memiliki Kartu Tanda Penduduk Kabupaten Rejang Lebong saja; 3. Legalisasi asset dalam Reforma Agraria menjadikan adanya kepastian hukum dalam pemilikan tanah oleh petani Kabupaten Rejang Lebong.
Contribution of Abu Yusuf's Thoughts to Economics
Authors: Lubis Riyani Fitri 
Published: January 2024

Activities related to economics, especially Islamic economics, have existed since the Prophet era. The rapid and advanced development of technology supports broader economic development. Besides, it encourages Islamic thinkers to contribute their thoughts related to economics, including Abu Yusuf. Indeed, the implementation of their thoughts needs to be restudied. This article aims to review the contribution of Abu Yusuf's thoughts to economics. This library research used descriptive qualitative methods by reviewing the results of Abu Yusuf's study on economics. The results of the review showed that first, the contribution of Abu Yusuf's thoughts to economics can be found in the Book of al-Kharaj which discusses taxation and state income for example, from ghanimah, fai, kharaj, ushr, jizyah, and charity. The book also discusses the utilization of state income based on Islamic principles. Besides, it also focuses on the activities of a country including economic activities such as fiscal policy, kharaj, public finances, and price mechanisms. Second, Abu Yusuf's thoughts influence economic activities and the book of al-Kharaj is used as a reference for contemporary economic studies so far.
Complications of Diabetes Mellitus: A Review Article
Authors: Bahri Suci Lousiana , Darmaningrat Cokorda Istri Agung Asvini , Putra I Wayan Maha , Adzuba Karina Khilmi , Paramita Luh Komang Dian Lakhsmi , Alfarisi Muhammad Duta , Irmayanto Tomi 
Published: January 2024

Introduction: Diabetes Mellitus is a chronic disease that will be suffered for a lifetime so the progressive disease will continue and can cause complications. Diabetes mellitus usually progresses slowly with symptoms that are mild to severe and can even cause death due to acute or chronic complications.

Content: Hyperglycemic crisis is one of the acute complications that can occur in Diabetes mellitus, both type 1 and type 2. This situation is a serious complication that may occur even in well-controlled diabetes mellitus.
Conclusion: Diabetic ketoacidosis and hyperglycemic Hyperosmolar State are acute complications of Diabetes mellitus. Both of these complications can be triggered due to inadequate insulin therapy and the presence of infection. Diabetic ketoacidosis is a condition characterized by metabolic acidosis due to excessive formation of ketones, while a hyperglycemic hyperosmolar state is characterized by severe hyperosmolality with serum glucose levels which are usually higher than diabetic ketoacidosis.
A pharmacoeconomic analysis from Italian guidelines for the management of prolactinomas
Authors: Basile Michele , Valentini Ilaria , Attanasio Roberto , Cozzi Renato , Persichetti Agnese , Samperi Irene , Scoppola Alessandro , Auriemma Renata Simona , Menis Ernesto De , Esposito Felice , Ferrante Emanuele , Iatì Giuseppe , Mazzatenta Diego , Maurizio Poggi  , Rudà Roberta , Tortora Fabio , Cruciani Fabio , Mitrova Zuzana , Saulle Rosella , Vecchi Simona , Cappabianca Paolo , Paoletta Agostino , Bozzao Alessandro , Caputo Marco , Doglietto Francesco , Ferraù Francesco , Lania Andrea Gerardo , Laureti Stefano , Lello Stefano , Locatelli Davide , Maffei Pietro , Minniti Giuseppe , Peri Alessandro , Ruini Chiara , Settanni Fabio , Silvani Antonio , Veronese Nadia , Grimaldi Franco , Papini Enrico , Cicchetti Americo 
Published: January 2024

Background: Prolactinoma, the most common pituitary adenoma, is usually treated with dopamine agonist (DA) therapy like cabergoline. Surgery is second-line therapy, and radiotherapy is used if surgical treatment fails or in relapsing macroprolactinoma.
Objective: This study aimed to provide economic evidence for the management of prolactinoma in Italy, using a cost-of-illness and cost-utility analysis that considered various treatment options, including cabergoline, bromocriptine, temozolomide, radiation therapy, and surgical strategies.
Methods: The researchers conducted a systematic literature review for each research question on scientific databases and surveyed a panel of experts for each therapeutic procedure’s specific drivers that contributed to its total cost.
Results: The average cost of the first year of treatment was €2,558.91 and €3,287.40 for subjects with microprolactinoma and macroprolactinoma, respectively. Follow-up costs from the second to the fifth year after initial treatment were €798.13 and €1,084.59 per year in both groups. Cabergoline had an adequate cost-utility profile, with an incremental cost-effectiveness ratio (ICER) of €3,201.15 compared to bromocriptine, based on a willingness-to-pay of €40,000 per quality-adjusted life year (QALY) in the reference economy. Endoscopic surgery was more cost-effective than cabergoline, with an ICER of €44,846.64. Considering a willingness-to-pay of €40,000/QALY, the baseline findings show cabergoline to have high cost utility and endoscopic surgery just a tad above that.
Conclusions: Due to the favorable cost-utility profile and safety of surgical treatment, pituitary surgery should be considered more frequently as the initial therapeutic approach. This management choice could lead to better outcomes and an appropriate allocation of healthcare resources.
Eksplorasi Potensi Bacillus spp. sebagai Bakteri Pemacu Pertumbuhan Tanaman di Hutan Primer Resort Kembang Kuning
Authors: Sidhiawan Anak Agung Putu , Sukiman Sukiman , Sarkono Sarkono , Hidayati Ernin , Suryadi Bambang Fajar 
Published: January 2024

Kembang Kuning resort is one of the Mount Rinjani National Park Resorts that have high biodiversity, so it has the potential for plant growth-promoting bacteria. Bacillus sp. is one species of bacteria that has great potential as a plant growth-promoting bacteria. The purpose of this study was to isolate and determine the ability of phosphate solubilization, nitrogen-fixing and anti-fungal activity of Bacillus spp. isolated from the Primary Forest of Kembang Kuning Resort, Gunung Rinjani National Park. This research is an exploratory study consisting of the isolation of Bacillus sp., phosphate solubilization test with spot inoculation method on Pikovskaya Agar media, qualitative nitrogen fixing test using Jensen's Nitrogen - Free media, and anti-fungal activity test against Fusarium sp. with dual culture method. There were 21 isolates of the genus Bacillus successfully isolated in this study. The phosphate solubilization test showed that 16 bacterial isolates could solubilize phosphate, where the highest phosphate solubilization index was produced by isolate P3.1 namely 0,52. A total of one isolate, namely isolate P3.1, can fix nitrogen on Jensen's Nitrogen-Free medium. In the anti-fungal test against Fusarium sp., three bacterial isolates were obtained that were able to inhibit the growth of Fusarium sp., where the highest antagonism was produced by isolate P2.8 which was 46,66%. Bacillus spp. isolated from Kembang Kuning Resort has potential as PGPB in terms of crop protection.
Delivery of internet-based cognitive behavioral therapy combined with human-delivered telepsychology in tinnitus sufferers through a chatbot-based mobile app
Authors: Bardy Fabrice , Jacquemin Laure , Wong Cara L. , Maslin Michael R. D. , Purdy Suzanne C. , Thai-Van Hung 
Published: January 2024

BackgroundWhile there is no cure for tinnitus, research has shown that cognitive behavioral therapy (CBT) is effective in managing clinical sequelae. Although traditional CBT is labor-intensive and costly, new online consultations may improve accessibility. Moreover, there is promise in an engaging conversational agent, or a “chatbot,” delivering CBT in a conversation-like manner and allowing users to work through complex situations with the guidance of a virtual coach. Currently, there is little research examining a possible hybrid model using iCBT and tele consultation with a psychologist.MethodsA randomized, 2 parallel-group trial was conducted to compare the clinical effectiveness of (1) iCBT delivered through a chatbot mobile app (i.e., Tinnibot only group) (2) Tinnibot combined with telepsychology (i.e., hybrid-intervention group). A total of 30 eligible adults with tinnitus were included. After an 8-week intervention period, participants were followed up for 2 months. The primary outcome measure, the Tinnitus Functional Index (TFI), and the secondary outcome measures, Hyperacusis Questionnaire (HQ), Generalized Anxiety Disorder 7-item (GAD-7), and Patient Health Questionnaire (PHQ-9), were assessed before treatment, post-treatment, and at follow-up.ResultsThe TFI decreased significantly over time in both groups, with a trend for a larger improvement in the group that received telepsychology. At post-treatment, a clinically significant improvement was observed in 42% of the Tinnibot-only group and 64% of the hybrid-intervention group. At follow-up, this was 64% for both groups. The secondary outcome measures, PHQ-9 and GAD-7 improved significantly over time, but the HQ did not.DiscussionInternet-based delivery of CBT is effective in decreasing tinnitus distress, and levels of anxiety and depression, which is more relevant today than ever in the context of a global pandemic that has challenged the delivery of face-to-face intervention. The addition of telepsychology might be beneficial, but not essential for the effectiveness of treatment. There is a need for further research to determine whether there is any relationship between the characteristics of tinnitus patients and the success of the different modes of delivery of therapy.
Clinical features and risk factors of liver injury in patients with Chlamydia psittaci pneumonia- a retrospective analysis
Authors: Guo Xuejing , Zhu Dan , Chen Hui 
Published: January 2024

BackgroundResearch into the effects of Chlamydia psittaci pneumonia on the liver has emerged in the last few years. However, no studies have systematically described liver injury in patients with psittacosis. We present the first report on the clinical features and risk factors of liver injury in patients with Chlamydia psittaci pneumonia.MethodsWe retrospectively collected the clinical parameters for 46 patients with Chlamydia psittaci pneumonia admitted to Jinhua Central Hospital from January 2019 to February 2023. We analyzed the liver function parameters and summarized the clinical characteristics and risk factors of liver injury.ResultsAmong the 46 patients, 39 (84.8%) had abnormal liver function, and 23 (50.0%) had liver injury. The ratio of patients with a history of alcohol consumption (39.1% vs. 4.3%, P =0.004) or severe pneumonia (56.5% vs. 26.1%, P =0.036) was higher in the liver injury group compared with the non-liver injury group. Laboratory tests showed higher lactate dehydrogenase (LDH) levels in the liver injury group (P &lt;0.001). The optimal cut-off LDH level associated with liver injury was 473 IU/L as determined by ROC curve analysis. Furthermore, multivariate logistic regression analysis demonstrated that a history of alcohol consumption (odds ratio [OR] = 11.251; 95% confidence interval [CI] = 1.022 ~ 123.897, P =0.048) and an LDH level of ≥ 473IU/L (OR = 11.635, 95% CI = 1.832 ~ 73.869, P =0.009) were independent risk factors for liver injury.ConclusionsA history of alcohol consumption and an LDH level of over 473 IU/L are independent risk factors for Chlamydia psittaci pneumonia-related liver injury. It is recommended that particular attention be given to monitoring and evaluating liver function parameters when treating patients with Chlamydia psittaci pneumonia who have a high LDH level and history of alcohol consumption.
Complexity of the online distrust ecosystem and its evolution
Authors: Illari Lucia , Restrepo Nicholas J. , Johnson Neil F. 
Published: January 2024

Introduction: Collective human distrust—and its associated mis/disinformation—is one of the most complex phenomena of our time, given that approximately 70% of the global population is now online. Current examples include distrust of medical expertise, climate change science, democratic election outcomes—and even distrust of fact-checked events in the current Israel-Hamas and Ukraine-Russia conflicts.Methods: Here we adopt the perspective of the system being a complex dynamical network, in order to address these questions. We analyze a Facebook network of interconnected in-built communities (Facebook Page communities) totaling roughly 100 million users who, prior to the pandemic, were just focused on distrust of vaccines.Results: Mapping out this dynamical network from 2019 to 2023, we show that it has quickly self-healed in the wake of Facebook’s mitigation campaigns which include shutdowns. This confirms and extends our earlier finding that Facebook’s ramp-ups during COVID-19 were ineffective (e.g., November 2020). We also show that the post-pandemic network has expanded its topics and has developed a dynamic interplay between global and local discourses across local and global geographic scales.Discussion: Hence current interventions that target specific topics and geographical scales will be ineffective. Instead, our findings show that future interventions need to resonate across multiple topics and across multiple geographical scales. Unlike many recent studies, our findings do not rely on third-party black-box tools whose accuracy for rigorous scientific research is unproven, hence raising doubts about such studies’ conclusions–nor is our network built using fleeting hyperlink mentions which have questionable relevance.
Helical cyclogenesis as an extreme threshold phenomenon in a rotating stratified moist atmosphere
Authors: Levina Galina 
Published: January 2024

In this paper, the concept of helical cyclogenesis is discussed, allowing for a unified interpretation of the existence of intense large-scale long-lived vortices in the atmosphere through the transfer of energy from cloud-scale motions. In 2022, the first evidence of such a phenomenon was found at Jovian high latitudes. The theory introduces ideas about large-scale threshold instabilities in turbulence with broken mirror symmetry. Such turbulence, called helical turbulence, occurs in a rotating, stratified, moist atmosphere. The present publication emphasizes the problem of tropical cyclogenesis in the Earth’s atmosphere. In the case of tropical cyclones, these ideas allowed, for the first time, the development of a procedure for the exact diagnosis of the emergence of large-scale helical-vortex instability and interpretation of this event as the birth of a tropical cyclone. Our very simple diagnostics and lucid quantitative criterion of the tropical cyclogenesis are discussed in the context of their successful application to two distinct idealized genesis scenarios and three observed tropical cyclones. In all cases, a nascent vortex became energy-self-sustaining and intensifying dozens of hours before the formation of a tropical depression. The pivotal role of rotating cumulonimbus clouds, known as vortical hot towers (VHTs), is highlighted. They are a necessary element both to provide and to diagnose the instability. These main actors of the helical cyclogenesis are illustrated by authors’ photos, satellite imagery, and animation from idealized atmospheric modeling. New fundamental and applied interpretations are offered. The hypothesis on the two-scale vortex dynamo-effect is put forward, which suggests the energy transfer from the VHTs scale, 10–30 km, directly to the mesoscales, hundreds km, of the system circulation of a tropical cyclone. Based on the results of the applied new diagnostics, we propose a definition of tropical cyclogenesis: interpret the onset of helical-vortex instability as the beginning of the genesis stage while considering the formation of a tropical depression as this stage completion. The diagnostics is best suited as a fundamental basis for detecting the “Potential Tropical Cyclone” stage introduced by the U.S. National Weather Service for operational forecasting purposes. Prospects are discussed.
Causal relationship between PCOS and related sex hormones with oral inflammatory diseases: a bidirectional Mendelian randomization study
Authors: Min Qiusi , Chen Yi , Geng Hongling , Gao Qian , Zhang Xueying , Xu Min 
Published: January 2024

BackgroundObservational studies have identified a strong association between polycystic ovary syndrome (PCOS) and hormone levels related to oral inflammatory diseases. To better understand the relationship between them, we conducted an analysis using a two-sample Mendelian randomization (MR) approach.MethodsWe gathered summary statistical data from previously published genome-wide association studies (GWAS) on PCOS and three sex hormones (AMH, Estradiol, LH) along with four oral inflammatory diseases (painful gums, loose teeth, mouth ulcers, and toothache). We selected single nucleotide polymorphisms (SNPs) as instrumental variables and employed four types of MR analysis methods to evaluate causal relationships between exposure and outcome. Finally, the robustness of our results was further validated through sensitivity tests and reverse MR.ResultsWe observed that PCOS could increase the risk of mouth ulcers (ORIVW= 1.0013, 95%CI: 1.0001-1.0025, PIVW = 0.0278), painful gums (ORIVW= 1.0015, 95%CI:1.0003-1.0027, PIVW = 0.0163), and loose teeth (ORIVW= 1.0014, 95%CI: 1.0001-1.0027, PIVW = 0.0328). Moreover, LH was also found to increase the risk of mouth ulcers (ORIVW= 1.0031, 95%CI: 0.0001-1.0062, PIVW = 0.0457). MR-Egger regression, weighted mode, and WE indicated similar results. Additionally, we discovered no causal link between PCOS and toothache (PIVW&gt;0.05), LH and painful gums, loose teeth, or toothache (PIVW&gt;0.05), or AMH and Estradiol level with any of the four oral diseases (PIVW&gt;0.05).ConclusionOur research provides new insights and references for exploring the effects of PCOS and related hormones on oral inflammatory lesions. For patients with PCOS, especially those with elevated LH levels, early intervention measures should be taken to prevent the occurrence of oral inflammatory diseases.
Evaluating the biocompatibility of ceramic materials for constructing artificial reefs
Authors: O’Reilly Logan M. , Willerth Stephanie M. 
Published: January 2024

IntroductionCoastal ecosystems, including reefs, are becoming increasingly threatened as anthropogenic development continues to encroach on intertidal habitats with little initiative to establish ecologically considerate infrastructure. Submerging human-made, shelter-providing structures known as artificial reefs (AR) can contribute to the preservation of these ecosystems. ARs are historically used for promoting the abundance and biodiversity of marine species for aquaculture, conservation, and ecotourism; and are typically made of concretes or metal structures. An AR’s success correlates to its ability to establish a surface layer of microorganisms, such as microalgae and bacteria, known as a biofilm. The productivity of the biofilm can be influenced by material surface properties. It is hypothesized that material pH and porosity affect the rate of biofilm formation.MethodsHere - a range of concrete mixtures were cast and submerged in circulating seawater and mass per surface area of biofilm accumulation was measured to evaluate this theory. These mixtures included standard Portland Cement (PC), PC with admixtures of diatomaceous earth (PDC) and limestone (PLC), fine-aggregate high-performance concrete (DUC), and terra cotta (TER). ARs were manufactured as 38mm tall cylinders, 76mm in diameter, and submerged in circulating seawater to evaluate mass per surface area of biofilm accumulation.ResultsOur results indicate that biofilm formation is directly affected by surface porosity and less-so by pH, as determined by measuring material properties after submersion. We found that the PDC samples were most successful in forming a biofilm despite being more fragile than other concrete samples.DiscussionThis preliminary study provides insight into how different material properties influence the accumulation of biofilm as a starting point for designing ARs. Future work will investigate the long-term performance of such samples in relevant conditions.
Molecular diagnosis of opportunistic infections in the central nervous system of HIV-infected adults in Manaus, Amazonas
Authors: de Melo Sabrina Araújo , Pinto Sérgio Damasceno , Ferreira Ewerton da Silva , Brotas Reinan , Marinho Eveny Perlize Melo , da Silva Valderjane Aprigio , Monte Rossiclea Lins , Feitoza Pablo Vinícius Silveira , Reis Monique Freire , Almeida Taynná V. Rocha , Ferreira Luiz Carlos de Lima , Bastos Michele de Souza 
Published: January 2024

BackgroundOpportunistic infections in the central nervous system (CNS) of people with HIV/AIDS (PLWHA) remain significant contributors to morbidity and mortality, especially in resource-limited scenarios. Diagnosing these infections can be challenging, as brain imaging is non-specific and expensive. Therefore, molecular analysis of cerebrospinal fluid (CSF) may offer a more accurate and affordable method for diagnosing pathogens.MethodsWe conducted extensive real-time PCR testing (qPCR) on CSF to evaluate etiological agents in PLWHA with neurological manifestations. Primers targeting DNA from specific pathogens, including cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein–Barr virus (EBV), John Cunningham virus (JCV), Toxoplasma gondii, and human T-lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2), were used.ResultsCerebrospinal fluid samples revealed 90 pathogens (36.7%). Toxoplasma gondii was the most frequently detected pathogen, found in 22 samples (30.5%). Other pathogens included Cryptococcus sp. (7.7%), EBV (5.3%), CMV, VZV, and JCV (4.0% each).ConclusionDespite antiretroviral therapy and medical follow-up, opportunistic central nervous system infections remain frequent in PLWHA. Herpesviruses are commonly detected, but T. gondii is the most prevalent opportunistic pathogen in our study population. Therefore, molecular diagnosis is a crucial tool for identifying opportunistic infections, even in patients undergoing treatment.