bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opioid Management Review Committee: Fostering Interdisciplinary Education and Support Amid the Ongoing US Opioid Overdose Crisis
Authors: Neale Kyle , Samala Renato V. , Lagman Ruth , Mullan Patricia B. , Shoemaker Laura 
Published: January 2024

Background Over the past two decades, pain and suffering caused by the U.S. opioid crisis have resulted in significant morbidity, policy reforms and healthcare resource strain, and affected healthcare providers’ efforts to manage their patients’ pain. In 2017, Cleveland Clinic’s Department of Palliative and Supportive Care established their Opioid Management Review Committee (OMRC), which focuses on patient safety, opioid stewardship, education on specialist pain management and addiction medicine skills, and offers emotional and informational support to colleagues managing complex pain cases. Objectives This quality assessment and improvement activity describes the organization and effects of the OMRC on healthcare workers in the department. Methods On February 1, 2023, an online survey was distributed to attendees of the OMRC. Participants were asked to provide their demographic information and free text responses to questions about the purpose of the OMRC, their judgment about the extent to which the OMRC has changed their approach to pain management, the OMRC’s impact on their approach to opioid management, its impact on the clinicians’ confidence in managing nonmedical opioid use or comorbid substance use, and suggestions to improve future meetings. Results Fifty-nine out of 79 clinicians completed the survey (75% response rate). Participants’ aggregate responses indicated that the committee fostered interdisciplinary collaboration, provided emotional and professional support, increased awareness of responsible opioid prescribing, and enhanced confidence in managing complex cases involving non-medical opioid use or comorbid substance use. Conclusion The OMRC represents a comprehensive interdisciplinary approach to safely manage opioid therapy during the contemporary opioid overdose crisis.
Evaluation of retinal and choroidal vascular structures in patients with anxiety disorder
Authors: Acan Durgul , Baykan Hayriye , Karahan Eyyup 
Published: January 2024

Purpose To evaluate the retinal and choroidal vascular structures in patients with anxiety disorders. Methods Thirthy-four eyes of 34 patients who were diagnosed with any anxiety disorders were compared with 32 eyes of 32 age- and sex-matched controls. Central macular thickness (CMT), foveal vascular zone (FAZ) area, total retinal vascular densities of superficial and deep capillary plexus (VDSCP, VDDCP), outer retinal and choriocapillary layers (ORL, CCL) blood flow rates, central subfoveal choroidal thickness (SFCT) and choriodal vascularity index (CVI) were evaluated with optical coherence tomography angiography (OCT-A) and enhanced depth imaging optical coherence tomography (EDI-OCT). Results No statistical differences were found between the study and control groups in terms of CMT, FAZ area, VDSCP, VDDCP, ORL and CCL blood flow rates. The mean SFCT was 346.26 ± 64.26 µm in patients with anxiety disorder and was found to be statistically significantly thicker than the control group (319.56 ± 37.19 µm) ( p = 0.042). Besides, CVI was significantly lower in the study group (71.09 ± 2.64 vs 73.13 ± 3.31, p = 0.008). Conclusion In people with anxiety disorders, the SFCT was found to be thicker and CVI was found to be lower than normal subjects. Although anxiety and stress are important factors in central serous chorioretinopathy, multifactorial factors, including ocular factors, play a role in the pathophysiology of the disease. There is a need for prospective studies with larger series on the subject.
Noninvasive screening of ocular surface disease in otherwise healthy patients scheduled for cataract surgery
Authors: Giannaccare Giuseppe , Borselli Massimiliano , Rossi Costanza , Carnovale Scalzo Giovanna , Pellegrini Marco , Vaccaro Sabrina , Scalia Giovanni , Lionetti Giovanna , Mancini Alessandra , Bianchi Pietro , Scorcia Vincenzo 
Published: January 2024

PurposeTo evaluate prevalence and characteristics of pathological ocular surface findings in healthy patients undergoing cataract surgery using a noninvasive ocular surface workup and a validated questionnaire.DesignProspective single-centre study (sub-analysis clinical trial no. NCT05754437).MethodsHealthy patients undergoing senile cataract surgery were screened preoperatively by Oculus Keratograph (K5 M; Oculus GmbH, Wetzlar, Germany) for the evaluation of tear meniscus height (TMH), non-invasive keratograph break-up time (NIKBUT), and meibomian gland dropout. Ocular discomfort symptoms were scored by ocular surface disease index (OSDI) questionnaire.Results120 eyes of 120 patients (62 females, 58 males; mean age 73.85 years, range 47–91 years) were included. All patients had at least 1 abnormal finding, while 19 (15.8%; 95% CI [0.09–0.22]) had alterations of all parameters. In detail, 39 patients (32.5%; 95% CI [0.24–0.41]) had pathological TMH (mean 0,15 mm [0.03 SD]), 102 (85%; 95% CI [0.79–0.91]) had pathological NIKBUT (mean 3.64 s [2.63 SD]), 117 (97.5%; 95% CI [0.95–1]) had some degree of gland dropout (mean 1.62 [0.70 SD]), 78 patients (65%; 95% CI [0.56–0.74]) had pathological OSDI scores (mean 28.63 [15.08 SD]). Using TFOS DEWS II criteria, 66 patients (55%; 95% CI [0.42–0.60]) resulted affected by dry eye.ConclusionsThis quick noninvasive screening documented the high prevalence of pathological ocular surface parameters in patients without risk factors or previous diagnosis of dry eye who are scheduled for cataract surgery.
Multicolour® imaging findings in residual emulsified silicone oil bubbles
Authors: Venkatesh Ramesh , Joshi Aishwarya , Choudhary Ayushi , Choubey Kritya , Prabhu Vishma , Bavaskar Snehal , Chhablani Jay 
Published: January 2024

Purpose To describe the findings of Multicolour® imaging (MCI) in the presence of residual emulsified silicone oil (SiO) droplets. Case report A 62-year-old man had previously undergone surgery for a traumatic retinal detachment in the left eye, followed by SiO removal a few years ago. His presenting visual acuity was 6/60 in the left eye and intraocular pressure was 12 mm Hg. Clinical examination revealed the presence of emulsified residual SiO droplets in the vitreous cavity, ‘inverse hyperoleon’ at the posterior pole and pathological myopia. Retinal findings were documented using optical coherence tomography (OCT), fundus autofluorescence (FAF), and MCI on the Spectralis (Heidelberg, Germany) machine. Results On OCT, the emulsified SiO droplets in the preretinal and intraretinal layers appeared as multiple hyperreflective dots with no underlying shadowing trapped beneath the residual posterior hyaloid or preretinal membrane in the region of the posterior staphyloma. Residual emulsified silicon oil on the retinal surface appeared to have greenish hue on the composite multicolour image and was hyperreflective on individual blue and green reflectance images and dark and hyporeflective on the infrared reflectance image. The SiO droplets appeared dark and were difficult to identify on the short wavelength FAF image. Conclusion To the best of our knowledge, this case report describes the MCI findings in emulsified SiO droplets for the first time.
Femtosecond laser-assisted cataract surgery versus conventional phacoemulsification: A meta-analysis of randomized controlled trials
Authors: Pichardo-Loera Nicole Stephanie , Corredor-Ortega Claudia , Castro-Monreal Miguel Angel , Massaro-Corredor Martha Gabriela , Pérez-Vázquez José Francisco , Gonzalez-Salinas Roberto 
Published: January 2024

Purpose The main purpose of our study is to compare the adverse events occurrence, complications, and postoperative outcomes of Femtosecond Laser-Assisted Cataract Surgery (FLACS) versus conventional phacoemulsification surgery (CPS) in adult patients undergoing cataract surgery. Methods We conducted our research using PubMed, Scopus, and MEDLINE through EBSCOhost from 2012 to July 2022 with English and Spanish language restriction, including only Randomized Controlled Trials (RCTs). The PRISMA guidelines were observed for data abstraction, including a random-effects model for each outcome. Results We analyzed 4844 eyes from 23 RCTs with some low risk of bias according to RoB 2 tool. We found statistically significant differences between the FLACS and CPS groups for the mean absolute error (MD = −0.12, 95% CI:−0.22–[−0.02], p = 0.01), the circularity of capsulorhexis (MD = 0.04, 95% CI: 0.04–0.05, p ≤ 0.00001), IOL centration ( D = −0.07, 95% CI:−0.09–[−0.05], p ≤ 0.00001), CDE count (MD = −1.75, 95% CI: −2.75-[−0.74], p = 0.0006), mean phacoemulsification time (MD = -12.90, 95% CI:−20.89-[−4.92], p = 0.002), EPT (MD = −0.93, 95% CI: −1.68-[−0.019], p = 0.01) and endothelial cell density loss ((MD = −0.6, 95% CI: −1-[−0.19], p = 0.004). Also, the safety analysis showed a lower incidence of posterior capsule tear (PCT) in the FLACS group (OR =0.29, 95% CI: 0.09–1, p = 0.05). Conclusions Our results suggest that FLACS might be helpful for patients with relatively dense cataracts and low preoperative endothelial cell values.
A hospital-based asynchronous ENT telehealth service for children with otitis media: Cost-minimisation and improved access
Authors: Altamimi Ali AH , Brennan-Jones Christopher G , Robinson Monique , Kuthubutheen Jafri , Herbert Hayley , Tran Tu Trang , Veselinović Tamara , Edmunds Melinda , Oremulé Babatunde , Alenezi Eman MA , Richmond Peter C , Choi Robyn SM , Li Ian 
Published: January 2024

Aim The purpose of this study is to explore the effectiveness of a hospital-based asynchronous ear, nose, and throat (ENT) telehealth service (the Ear Portal) in reducing cost and improving access for children with otitis media. Methods Participants were recruited to the Ear Portal from a tertiary hospital ENT waiting list. Ear and hearing assessments were conducted during appointments by the Ear Portal research assistant, and data was stored for an asynchronous review by the Ear Portal multidisciplinary team. A cost-minimisation analysis was conducted for the Ear Portal and the standard care pathways. Waiting times to provide care for both pathways were calculated for children with semi-urgent (i.e. Category 2) and non-urgent (i.e. Category 3) referrals. Results The running cost for the Ear Portal was $67.70 for initial appointments and $37.34 for follow-up appointments. Conversely, the running cost for the standard care pathway was $154.65 for initial appointments and $86.10 for follow-up appointments. A total of 223 appointments were required to offset the initial Ear Portal investment of $19,384.00. The median waiting time for the Ear Portal from initial contact to care plan delivery was <30 days, whereas the median waiting times for children in the standard care pathway were 291 days (interquartile range (IQR) = 117) for Category 2 and 371 days (IQR = 311) for Category 3 referrals. Conclusion Under the current circumstances, the Ear Portal service can reduce costs for the health care system by reducing marginal costs per patient in addition to providing ENT specialist care within the clinically recommended timeframes.
The moderating effect of multilingualism on the relationship between EFL learners’ grit, enjoyment, and literacy achievement
Authors: Calafato Raees 
Published: January 2024

Aims and Objectives/Purpose/Research Questions: The study investigated the relationship between the L2 grit, domain-general grit, foreign language enjoyment (FLE), multilingualism, and self-reported literacy achievement of students learning English as a foreign language (EFL) in public upper-secondary schools in Norway. Specifically, the study sought to identify predictors of students’ EFL reading and writing achievement and examine the moderating effect of multilingualism on the relationship between L2 grit, FLE, and such achievement. Design/Methodology/Approach: A quantitative research design was employed, and data were collected through an online questionnaire. Convenience sampling was used to recruit 181 upper-secondary school students learning EFL in southeastern Norway (one participant’s responses were discarded because they were incomplete). Data and Analysis: Paired and independent sample t-tests and moderated multiple regression were used to analyse the collected data. Findings/Conclusions: The study found that the perseverance component of L2 grit and daily language use (one of two aspects of multilingualism used in the study) positively predicted both reading and writing achievement (the consistency of interest component of L2 grit only positively predicted writing achievement). In addition, daily language use was found to negatively moderate the relationship between the perseverance component of L2 grit and reading and writing achievement, with the moderating effect dissipating as additional languages were used daily. Originality: The study is among the first to explore the interplay between grit and multilingualism in the Nordic region and examine the relationship between multilingualism, grit, FLE, and achievement globally. Significance/Implications: The study’s findings underscore the need for researchers to develop and use more comprehensive multidimensional measures of multilingualism when investigating its effects on language learning in formal contexts, design scales for grit that target specific language skills, and broaden grit-related research to cover the learning of multiple language and non-language subjects concurrently.
Efficacy and safety of NeuroEndoscopic Surgery for IntraCerebral Hemorrhage: A randomized, controlled, open-label, blinded endpoint trial (NESICH)
Authors: Wang Long , Zhou Tengyuan , Wang Pangbo , Zhang Shuixian , Yin Yi , Chen Lin , Duan Haijun , Wu Na , Feng Hua , Hu Rong 
Published: January 2024

Background: Neuroendoscopy is a minimally invasive procedure for clot evacuation in intracerebral hemorrhage (ICH) which may have advantages compared with open surgical evacuation procedures. The application of neuroendoscopy in ICH has attracted increasing attention in recent years. However, it remains unclear whether it could improve outcomes in patients with ICH. Objective: The aim of this study is to explore the efficacy and safety of neuroendoscopic hematoma evacuation surgery compared with standard conservative treatment for spontaneous deep supratentorial cerebral hemorrhage. Methods: The Efficacy and safety of NeuroEndoscopic Surgery for IntraCerebral Hemorrhage (NESICH) Trial is a multicenter, randomized, controlled, open-label, blinded-endpoint clinical trial. Up to 560 eligible subjects with acute deep supratentorial ICH will be randomly assigned (1:1) to receive either neuroendoscopic hematoma evacuation or standard conservative treatment at more than 30 qualified neurosurgery centers in China. Outcomes: The primary endpoint is the proportion of patients with a good functional outcome (mRS score 0–3) in both groups at 180 days after onset. The main safety endpoints include all-cause mortality at 7, 30, and 180 days, rebleeding at 3, 7, and 30 days, and serious complications within 180 days. Discussion: NESICH will provide high-quality evidence for the efficacy and safety of neuroendoscopic hematoma evacuation surgery in ICH patients. Trial registration: ClinicalTrials.gov NCT05539859.
La equidad en la campaña de vacunación COVID de la Provincia de Buenos Aires (Argentina): un análisis del Municipio de Quilmes
Authors: Spadea Agostina , Oleiro Hidalgo Maria , Quevedo Sofía , Begue Carolina , L’Arco Gabriela , Pérez Adriana , Cueto Gerardo , Konfino Jonatan 
Published: January 2024

Introducción: la pandemia de la COVID-19 ha acentuado las desigualdades sociales, económicas y relacionadas con la salud, afectando desproporcionadamente a las personas en situación de vulnerabilidad y perpetuando la inequidad en salud. En Argentina se implementó una campaña nacional gratuita de vacunación contra la COVID-19 con una perspectiva de equidad. Objetivo: identificar desigualdades territoriales en el acceso a la vacunación contra la COVID-19 en Quilmes. Métodos: se analizó la información referida a la vacunación contra la COVID-19 de personas residentes en el Municipio. Se efectuó la georreferenciación de cada vacunatorio y de cada persona a partir del domicilio declarado en el momento de la vacunación. Para caracterizar el grado de vulnerabilidad de las personas vacunadas, a cada una se le asignó el índice de carencias múltiples (ICM) correspondiente al radio censal de residencia Resultados: al menos el 82 % de la población completó el esquema primario de vacunación (dosis 1 y dosis 2), porcentaje que alcanzó el 97 % en los mayores de 65 años. Analizando la media de dosis aplicadas se observa algo similar con un gradiente hacia los quintiles más altos pero con una mínima diferencia entre sí, situación que también se corrobora en todos los grupos etarios. Discusión: no se observaron brechas significativas entre los diferentes niveles socioeconómicos. Si bien se observó un mínimo gradiente en el promedio de dosis recibidas, el tiempo de acceso a las diferentes vacunas y el porcentaje de esquemas primarios completos recibidos, las mismas tienen escasa relevancia clínica y sanitaria.
Comparison of osimertinib plus bevacizumab against osimertinib alone in NSCLC harboring EGFR mutations: a systematic review and meta-analysis
Authors: Zhou Guojin , Guo Liuxian , Xu Jing , Tang Kejing , Chen Jie 
Published: January 2024

Background: Frequent failures observed in some trials comparing the efficacy and safety of osimertinib plus bevacizumab to osimertinib monotherapy in advanced non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) alterations have brought questions. Objectives: To evaluate the efficacy and safety of these two treatment regimens in advanced NSCLC patients harboring EGFR mutations. Design: This study is a systematic review and meta-analysis. Data sources and methods: PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases were extensively searched for relevant randomized controlled trials (RCTs) on 14 May 2023. Two researchers independently screened the literature, assessed quality, and extracted data. The primary outcomes were progression-free survival (PFS), overall survival (OS), and objective response rate (ORR). The secondary outcomes were adverse events (AEs) and PFS stratified by patients’ characteristics. STATA 17.0 software (StataCorp LLC, USA) was adopted for meta-analysis. Results: A total of four RCTs involving 390 patients were included. Overall, the risk of bias across the studies was moderate to low. Pooled results showed that compared to osimertinib alone, the addition of bevacizumab to osimertinib failed to show prolongation of PFS [hazard ratio (HR) = 1.00, 95% confidence interval (CI): 0.78–1.27], OS (HR = 1.01, 95% CI: 0.73–1.41), or improvement of the ORR (risk ratio = 1.12, 95% CI: 0.90–1.38), while an increased incidence of some AEs was observed, such as nausea, oral mucositis, hypertension, and proteinuria. Notably, combination treatment did significantly prolong the PFS in the subset of smokers (HR = 0.64, 95% CI: 0.44–0.94). A mild trend toward PFS benefit under the combined regimen was also noted in patients with brain metastases and first-line treatment, though not reaching statistical significance. Conclusion: Based on the available evidence, the addition of bevacizumab to osimertinib could not provide additional survival benefits with higher but manageable toxicity for EGFR-mutant NSCLC patients. Osimertinib monotherapy remains the prioritized treatment. Further investigation is warranted.
An Exploratory Analysis of Preclinical and Clinical Factors Associated With Sleep Disturbance Assessed via the Neuro-QoL After Hemorrhagic Stroke
Authors: Ecker Sarah , Lord Aaron , Gurin Lindsey , Olivera Anlys , Ishida Koto , Melmed Kara R. , Torres Jose , Zhang Cen , Frontera Jennifer , Lewis Ariane 
Published: January 2024

Background and Purpose Sleep disturbance after hemorrhagic stroke (intracerebral or subarachnoid hemorrhage) can impact rehabilitation, recovery, and quality of life. We sought to explore preclinical and clinical factors associated with sleep disturbance after hemorrhagic stroke assessed via the Quality of Life in Neurological Disorders (Neuro-QoL) short form sleep disturbance inventory. Methods We telephonically completed the Neuro-QoL short form sleep disturbance inventory 3-months and 12-months after hemorrhagic stroke for patients >18-years-old hospitalized between January 2015 and February 2021. We examined the relationship between sleep disturbance (T-score >50) and social and neuropsychiatric history, systemic and neurological illness severity, medical complications, and temporality. Results The inventory was completed for 70 patients at 3-months and 39 patients at 12-months; 18 (26%) had sleep disturbance at 3-months and 11 (28%) had sleep disturbance at 12-months. There was moderate agreement (κ = .414) between sleep disturbance at 3-months and 12-months. Sleep disturbance at 3-months was related to unemployment/retirement prior to admission ( P = .043), lower Glasgow Coma Scale score on admission ( P = .021), higher NIHSS score on admission ( P = .041) and infection while hospitalized ( P = .036). On multivariate analysis, sleep disturbance at 3-months was related to unemployment/retirement prior to admission (OR 3.58 (95% CI 1.03-12.37), P = .044). Sleep disturbance at 12-months was related to premorbid mRS score ( P = .046). Conclusion This exploratory analysis did not demonstrate a sustained relationship between any preclinical or clinical factors and sleep disturbance after hemorrhagic stroke. Larger studies that include comparison to patients with ischemic stroke and healthy individuals and utilize additional techniques to evaluate sleep disturbance are needed.