bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mathematical Model and Numerical Simulation of Waterflood Induced Dynamic Fractures of Low Permeability Reservoirs
Authors: Du Kai , Rui Zhenhua , Dindoruk Birol , Yang Tao , Patil Shirish 
Published: October 2023

Abstract
As a powerful technique for reservoir simulation, the embedded discrete fracture model (EDFM) has been widely used for unconventional fracture reservoirs. However, the appearance of dynamic fractures caused by fracture extension during well stimulation brings significant challenge to reservoir simulation. We presented a new numerical method to model the dynamic fracture performance for horizontal wells in unconventional reservoirs by using EDFM in this study. The proposed method includes a numerical model and a workflow to simulate water-oil flow in an unconventional fracture reservoir. The fracture dynamics are not only considered into the pressure-dependent properties of fractures (such as fracture permeability, porosity), but also incorporated into EDFM by activating or deactivating grid blocks of fractures at each time step. Fracturing treatment data during stimulation and microseismic data after hydraulic fracturing provide a quantitative understanding of the dynamic fracture behaviors, including fracture location and geometries with time. We conducted a comparative analysis with respect to static fracture properties and dynamic fracture properties. In comparison to static fractures, dynamic fractures have a substantially higher bottomhole pressure. We also analyzed how production was impacted by shut-in time and water injection rate. Different production systems have varying cumulative oil and water production, and an optimal production system was identified. The quantitative understanding of fracture dynamics for field application examples helps to achieve more accurate production estimation.
Novel Retarded Acid System Improves Acid Fracturing in High-Temperature Gas Wells
Authors: Al Jama Majid A. , Sahu Qasim A. , Ali Eyad A. , AlMajed Mohammed S. , Cairns Amy J. , Sayed Mohammed 
Published: October 2023

Abstract
The oil and gas industry continue to rely on chemical methods for well stimulation of carbonate-rich formations, particularly hydrochloric acid (HCl). The selection is primarily driven by the fact that it is cost-effective and readily reacts with calcium and magnesium-based carbonates to yield soluble products. However, enhancing the fracture half-length using conventional HCl treatments in acid fracturing operations in high-temperature reservoirs remains a challenge. This is because the fast reaction rate between HCl and the rock matrix causes the acid to be rapidly spent and thus hinders deeper placement into the formation. These limitations were tackled through the development of a novel retarded acid system, referred to as LVAS-1 (Low Viscosity Acid System-1).
The new acid system is prepared by blending a strong mineral acid with a suitable strong organic acid while minimizing the amount of free water in the formulation as a mechanism to control dissociation of the acid and afford the desired retardation properties. This new single-phase low-viscosity acid system has proven its effectiveness in acid fracturing applications. The technology was trial tested in high temperature/high pressure conditions to fracture a conventional gas well in the Middle East. The motivation for field testing this system was to significantly increase the etched fracture half-length and maximum attainable pump rates over the current standard emulsified acid system. This was achieved by controlling both the engineering parameters during the treatment and the acid retardation properties. A rigorous post-treatment analysis was conducted to evaluate the performance of this acid system and benchmark it to previously tested acid systems. This includes pressure transient analysis, post–frac flow back, and friction pressure calculations. Pressure measurements relied on installing downhole gauges for friction calculations and Pressure Build-up (PBU) analysis.
We report here the successful development and deployment of a novel engineered hybrid acid system that overcomes the limitations associated with using emulsified acids. Specifically, the technology exhibits superior retardation properties, the ability to pump at higher rates due to lower friction pressure, and the formulation preparation method reduces operational complexity at the wellsite. Acid fracturing operations using the new acid system have proven successful, as evidenced by the prolonged gas production rate. Results of the PBU analysis show finite-conductive fractures in the reservoir with half-lengths higher than conventional acid systems and negative skin factor.
This paper presents a success story, i.e., from laboratory-to-field scale, in the development and utilization a new retarded acid system for acid fracturing applications. It highlights essential design parameters specific to the new system and lists the advantages and limitations over conventional emulsified acid systems.
Accelerating the Permanent CO2 Storage Process – A Safer and Faster Route to Net Zero
Authors: Mishra Shubham 
Published: October 2023

Abstract
Carbon dioxide (CO2) storage is a key element of the Carbon Capture Utilization and Storage (CCUS) process. While there can be several ways of storing CO2, it's underground storage is the most feasible method perceived today. However, underground CO2 storage is fraught with serious safety and environmental concerns beyond economic viability of the CCUS value chain. These concerns can be largely prevented if the CO2is converted into solid state in the subsurface. This phase change of CO2in subsurface condition is a very time-taking process and can take up to more than 100 years in most cases.
This paper proposes two new methods of accelerating the solidification (or mineralization) of CO2 in subsurface conditions, and thus accelerating the time-cycle of a CO2storage process. It also reviews some of the industry and academic works in accelerating the solidification of CO2.
Successful Hydraulic Fracturing Breakthrough in New Low Quality Reservoir Target from Paku Field, Rokan Block, Central Sumatra Basin
Authors: Kurniawan Hendri , Pradana Aulia , Safarina Aulia Sherly , Prasetio Mario Hadinata , Kristanto Irwan , Tjahjono Hendro 
Published: October 2023

Abstract
Paku Field is a relatively small oil field that is located in Rokan block, Central Sumatra Basin. Paku field had a long production history since 1988 with current recovery factor 24%. The field is still under primary depletion with ESP as its major artificial. Currently, Paku field has two active producers with total oil production of around 100 BOPD. Paku field mostly conducted regular well intervention & well service (add perforation and pump recondition) to maintain/improve production, while special well stimulation like hydraulic fracturing was last conducted in 2016 on Paku #04. Paku #04 fracturing job targeting MGL1 sd with reservoir properties average resistivity 20 ohmm, average porosity 13%, average permeability 44 mD and reservoir pressure 1600 psi. Hydraulic fracturing stimulation in this reservoir successfully conducted resulted in 311 BOPD oil gain and 24% water cut from commingle several reservoirs. Until now Paku #04 is still a good oil producer from the same reservoirs with oil average 60 BOPD and water cut 77%.
Looking at the historical success story of Paku #04 as an analog, Paku #05 also has similar low-quality reservoir sand but from the different geological formations that is BK1 sd. The BK1 sd has reservoir properties of 32 ft net pay, 18 Ohmm resistivity, 11% average porosity, 25 mD average permeability and 1534 psi reservoir pressure. The fracturing job in Paku #05 was successfully executed in October 2022 targeting BK1 sd. The job was conducted with several improvements from the previous job of Paku #04 such as conducted with three times more proppant volume (63 k vs 21 k previously), full sand body perforation, and produced from single zone. Hydraulic fracturing stimulation in Paku #5 resulted in initial production of 242 BOPD and water cut 60%.
Hydraulic fracturing jobs have been proven as one of the solutions to significantly improved production in primary fields such as Paku Field. Especially to improve production from reservoirs that are identified to have oil in low-quality reservoirs in other well or in another reservoir in Paku Field and from other fields that has the same reservoir properties characteristic.
A Pumping Well Wireless Communication Technology Based on Load Pulse of Sucker Rod
Authors: Yang Qinghai , Liao Chenglong , Hao Zhongxian , Shen Qiaochu , Xu Jilei , Zhao Hongyu , Li Yuan , Du Shuming 
Published: October 2023

Abstract
Pumping wells are characterized by fluid discontinuity, complex media, and periodic pump inspection. The data transmission technology, such as preset cable and pressure wave, which are widely used in injection wells, suffers from many problems when applied in pumping wells, such as high cost, complicated technique, and not suitable for pump inspection operation. As a result, there is an urgent need to develop low-cost wireless transmission technologies suitable for pumping well.
This paper proposes an innovative wireless communication technology for pumping well based on the load pulse of sucker rod. Its main components include a downhole load pulse generator (DLPG) and a ground communication controller (GCC). The DLPG is installed between the tubing pump barrel and the stationary valve and is equipped with an 8.5 mm diameter stepless adjusting valve that provides access between the pump chamber and annulus. During the operation of the pumping unit, adjusting the opening or closing state of the adjusting valve can change the working state of the tubing pump and thus change the normal lifting load of the pumping unit. Therefore, wireless uploading of downhole data can be realized by modulating downhole data into lifting load pulse and demodulating of load pulse by the GCC.
The principle and transmission characteristics of the technology have been tested in Jilin Oilfield. The results show that the opening or closing of the adjusting valve of the DLPG generate controllable and identifiable lifting load pulses at the wellhead. Moreover, with the increasing opening of the adjusting valve, the lifting load increases significantly. The average load when the adjusting valve is fully opened is 33.65kN, an increase of 64.7% compared with the normal lifting load. When the adjusting valve is completely closed, the lifting load quickly drops to normal. In addition, at 980 m pump setting depth, the response delay of lifting load dynamic change is very small. The pressure sensor of the DLPG can recognize the pressure changes of the pump chamber and accurately judge the up and down stroke. Using stroke recognition and load pulse automatic control, the downhole data uploading is successfully realized, and the technical principle and feasibility are verified.
This technology realizes wireless uploading of downhole data without changing the structure and working mode of the existing pumping well. It has the advantages of simple structure, easy installation, low cost, and no influence of pump inspection operation. It can be adapted to the current situation of the large number and wide distribution of pumping wells in China, and is expected to provide a new means of communication for improving the downhole understanding of pumping wells.
A detailed procedure to maximize IgM-induced Leishmania major mating in vitro
Authors: Serafim Tiago D. , Valenzuela Jesus G. 
Published: October 2023

Abstract
The steps presented here were developed to maximize the production of Leishmania hybrids in vitro. Our protocol was developed by mimicking as closely as possible the environment inside the gut of the sand fly where we successfully and consistently produced hybrids in vivo. It is important to note that producing hybrids in vitro is less optimal than producing them in vivo. Following this step-by-step protocol faithfully and carefully will significantly improve the success of producing hybrids in vitro.
Risk factors of chemotherapy-induced thrombocytopenia after oxaliplatin-containing chemotherapy for gastrointestinal malignancies
Authors: Li Ju , Wang Wanqing , Jiang Kaipeng , Cui Jiuwei , Wang Chang , Liang Tingting , Wang Yizhuo , Liu Shuhan , Zhou Wenshuo 
Published: October 2023

Abstract

Purpose
Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities. We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia (CIT) in patients with gastrointestinal tumors to guide the clinic.
Methods
Clinical data of 750 patients with a malignant gastrointestinal tumor were included as the primary cohort. Basic clinical data, serological indices, and anthropometric indices of these patients were collected. Grouped based on the presence or absence of CIT, univariate analysis was performed to identify significant factors related to chemotherapy-induced thrombocytopenia. Based on the results of multi-factor analysis, a nomogram was constructed using R language programing and its fitness was evaluated using the calibration curve and ROC curve.
Results
Univariate analysis identified 20 factors as closely related to CIT occurrence. The binary logistic multivariate regression analysis revealed five independent risk factors for developing CIT (P < 0.05): the M stage, total dose of oxaliplatin, albumin, baseline thrombocyte count, and natural killer (NK) cell count. The calibration curve of the monogram shows that the combined predictors had good consistency. A better prediction efficiency was observed with the ROC curve of 0.877 with the cut-off value of 0.3579613 (with sensitivity of 78.9% and specificity, 81.8%).
Conclusion
The total dose of oxaliplatin, M stage, albumin, baseline platelet count, and NK cell count were independent risk factors for CIT.
Influence of tool speed movement during cutting honeycomb block on its vibration resistance and cutting accuracy
Authors: Saramud Mikhail V. , Brungardt Maksim , Tololo Alexandr , Talay Evgeniy , Peteckaya Angelina 
Published: October 2023

Abstract
The state of cutting blanks from honeycomb fabric methods is associated with difficulties of rectilinear cutting of cell walls, which leads to a non-straight edge after cutting with a cutting tool. Such a form of curvilinear trajectory of the cutting tool movement is a consequence of the cutting-edge vibration in the process of moving towards cutting. In order to eliminate this effect, it is necessary to determine optimal cutting speed at which the blade and the honeycomb wall will not be in the resonance.
Amplifying the HIV Risks - Patterns of alcohol and drugs among female sex workers and men who as sex with men in Mozambique
Authors: Baltazar Cynthia Semá , Muleia Rachid , Banze Auria , Boothe Makini 
Published: October 2023

Abstract
Background: Abusive alcohol and drug consumption can increase the risk of acquiring HIV due to compromised decision-making linked to risky sexual behaviors. In this study, we explore the patterns of hazardous alcohol and drug use and correlates among female sex workers (FSW) and men who as sex with men (MSM) in Mozambique.
Methods: We conducted a secondary data analysis of a bio-behavioral survey (BBS) using a respondent-driven sampling method, which was conducted in five main urban areas of Mozambique from 2019-21. Selection criteria for the MSM were being a biological male with at least 18 years of age and reported oral or anal intercourse with a man in the previous 12 months; FSWs criteria was being a biological female with at least 15 years of age and reported exchanging sex for money, services or goods in the previous 6 months.
Results: The prevalence of hazardous alcohol drinking was 47.1% for FSW and 48.9% for MSM. Current drug use was reported in 13.3% of FSW. FSW with hazardous alcohol drinking were 47.1%. They reported higher number of sexual partners in the last month (55.3% vs 47,1%, p<0.001), STI in the last year (62,5% vs 48,2%, p<001), physical (53.5% vs 46.7%, p<0.0001) and sexual violence (54.7% vs 44.2%, p< 0.001), and HIV prevalence (55.2% vs 44.2 p<0.001). MSM with hazardous alcohol drinking was 48.9%. They reported higher STI (52.8%vs 45.4%, p<001), sexual violence (18.0% vs 8.3%, p<0.001) and HIV prevalence (53.0% vs 46.3 p<0.001). In addition, FSW that used drugs had a high perception of HIV risk, (14.2% vs 9.7%, p=0.005), had their first sexual experience when younger than 15 years old (15.4% vs 5.3% p<0.001), self-reported an STI (17.9% vs 10.2%, p< 0.001) in the last year, experienced physical violence (17.4% vs 7.0% p<0.001) and sexual violence (18.6% vs 8.9%, p<0.001).
Conclusion: There is an immediate need for the introduction and integration of site-specific substance use harm mitigation and mental health interventions into HIV prevention programs, particularly those targeting key populations in Mozambique.
Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs
Authors: Deng Wisteria , Holt Daphne , Tuominen Lauri , Sussman Rachel , Leathem Logan , Vinke Louis 
Published: October 2023

Abstract
The persecutory delusion represents the most common symptom of psychosis, yet its underlying neurobiological mechanisms are poorly understood. Prior studies have suggested that abnormalities in medial temporal lobe-dependent associative learning may contribute to this symptom, leading to diminished “safety signaling.” In the current study, this hypothesis was tested in a non-clinical sample of young adults without histories of psychiatric treatment (n = 64), who participated in a classical Pavlovian fear conditioning paradigm while fMRI data were collected. During the fear conditioning procedure, participants viewed face stimuli which were paired (the CS+) or not paired (the CS-) with an aversive stimulus (a mild electrical shock). Fear conditioning-related neural responses were measured in two medial temporal lobe regions, the amygdala and hippocampus, and in other closely connected brain regions of the salience and default networks. The participants without persecutory beliefs (n = 43) showed greater responses to the CS- compared to the CS+ in the right amygdala and hippocampus (a “safety signal”), while the participants with persecutory beliefs (n = 21) failed to exhibit this response (ps > .05). These between-group differences were not accounted for by symptoms of depression, anxiety or the psychosis prodrome. However, the severity of subclinical psychotic symptoms overall was correlated with the level of this aberrant response in the amygdala (p = .013) and hippocampus (p = .033). Thus, these findings provide evidence for a disruption of medial temporal lobe-dependent associative learning in subclinical psychotic symptoms, specifically persecutory thinking.
Domestic Pigs are Susceptible to Experimental Infection with Non-Human Primate-Derived Reston Virus Without the Need for Adaptation
Authors: Lewis Charles E. , Pinette Mathieu M. , Lakin Steven M. , Smith Greg , Fisher Mathew , Moffat Estella , Embury-Hyatt Carissa , Pickering Brad S. 
Published: October 2023

Abstract
Domestic pigs are a critical component of the food supply and one of the most commonly raised production animals. Pork consumption has driven the intensification of pig production expanding into environments conducive to increased emergence and spread of infectious diseases, including the spillover of pathogens into human populations. One of these emerging viruses, Reston virus (RESTV), is an enigma among the Ebolavirus genus in that its lack of human pathogenicity is in stark contrast to the high virulence associated with most other ebolaviruses. RESTV is, however, associated with outbreaks of highly lethal hemorrhagic disease in non-human primates (NHP), as well as poorly understood clinical manifestations of mixed virulence and lethality in naturally and experimentally infected domestic pigs. Our results show it is possible for RESTV derived from an NHP to infect domestic pigs resulting in a spectrum of disease, from asymptomatic to severe respiratory distress. Further, we report on the first experimental transmission of RESTV between infected pigs and a co-housed, naïve animal, as well as the first report of the successful use of group oral fluids for the detection of RESTV RNA and virus-specific IgA antibodies.
Phylogenetic analysis and morphological characterization of Phytophthora palmivora causing stem canker disease of durian in Malaysia
Authors: Danial Nor Dalila Nor , Asib Norhayu , Sadi Tosiah , Ismail Siti Izera 
Published: October 2023

Abstract

Stem canker, caused by Phytophthora palmivora, poses a significant challenge for durian farmers in Malaysia. However, limited research has explored the genetic diversity of this pathogen using multiple genes. In this study, we aimed to characterize Phytophthora isolates associated with symptomatic durian tissues from four Malaysian states (Selangor, Perak, Pahang, and Melaka). We employed both morphological and molecular methods, including sequence analysis of the internal transcribed spacer (ITS) rDNA and the cytochrome oxidase c (COX) multi-locus combination of subunit I and subunit II gene regions. A total of 21 Phytophthora palmivora isolates were obtained from diseased durian stem tissues and identified based on phylogeny and morphological characteristics. Molecular identification using BLASTn analysis of the ITS and COX sequences confirmed their identity as P. palmivora showing sequence similarity ranging from 99 to 100% with the ex-type culture of P. palmivora (GenBank accession no. ON834450 for the ITS region and JF771543 for the COX region). Phylogenetic analyses of the ITS rDNA and COX further confirmed that all Phytophthora isolates belonged to P. palmivora, forming a distinct clade with reference P. palmivora isolates, with strong bootstrap values for the ITS (99%) and COX (76%) regions. Pathogenicity tests demonstrated that all isolates were pathogenic to durian leaves, with PMM02 displaying significantly lower virulence compared to other tested isolates. Detached leaf assays conducted with durian leaves from D10, D24 and Mousang King varieties revealed significance differences among durian varieties, with D10 exhibiting higher susceptibility to P. palmivora.