bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of renal denervation on cardiac remodeling in resistant hypertension: A meta‐analysis
Authors: Xie Linfeng , Li Yuanzhu , Luo Suxin , Huang Bi 
Published: January 2024

AbstractTwelve studies involving 433 patients were included. After RDN treatment, LVMI decreased by 13.08 g/m2 (95% confidence interval [CI]: −18.38, −7.78; p < .00001), PWTd decreased by 0.60 mm (95% CI: −0.87, −0.34; p < .00001), IVSTd decreased by 0.78 mm (95% CI: −1.06, −0.49; p < .00001), and LVEF increased by 1.80% (95% CI: 0.71, 2.90; p = .001). However, there were no statistically significant improvements in LVIDd (95% CI: −1.40, 0.24; p = .17) and diastolic function (E/A) (95% CI: −0.04, 0.14; p = .28). Drug treatment for resistant hypertension (RH) is challenging. Renal denervation (RDN) is one of the most promising treatments for RH. Although studies have shown RDN can control blood pressure, the impacts of RDN on cardiac remodeling and cardiac function are unclear. This meta‐analysis evaluated the effect of RDN on cardiac structure and function in patients with RH. PubMed, Embase, and Cochrane were used to conduct a systematic search. The main inclusion criteria were studies on patients with RH who received RDN and reported the changes in echocardiographic parameters before and after RDN. Echocardiographic parameters included left ventricular mass index (LVMI), end‐diastolic left ventricular internal dimension (LVIDd), left ventricular end‐diastolic posterior wall thickness (PWTd), end‐diastolic interventricular septum thickness (IVSTd), E/A, and left ventricular ejection fraction (LVEF). Data was analyzed using RevMan. Twelve studies involving 433 patients were included. After RDN treatment, LVMI decreased by 13.08g/m2 (95%confidence interval [CI]: −18.38, −7.78, p < .00001), PWTd decreased by 0.60mm (95% CI: −0.87, −0.34, p < 0.00001), IVSTd decreased by 0.78mm (95% CI: −1.06, −0.49, p < .00001), and LVEF increased by 1.80% (95% CI: 0.71, 2.90, p = .001). However, there were no statistically significant improvements in LVIDd (95% CI: −1.40, 0.24, p = .17) and diastolic function (E/A) (95% CI: −0.04, 0.14, p =.28). This meta‐analysis finds that RDN can improve left ventricular hypertrophy and ejection fraction in patients with RH but has no significant effect on LVIDd and diastolic function. However, more studies are warranted due to the lack of a strict control group, a limited sample size, and research heterogeneity.
The prognostic value of the visually assessed time difference between mitral valve and tricuspid valve opening score for patients with heart failure with mildly reduced ejection fraction
Authors: Yue Yin , Wu Xiaopeng , Guan Xiaonan , Wu Xuejiao , Zhang Jianjun 
Published: January 2024

AbstractBackgroundThe visually assessed time difference between the mitral valve and tricuspid valve opening (VMT) score was correlated with the increase of left ventricular filling pressure (LVFP).HypothesisWe suspected that the VMT score might be a valuable prognostic biomarker for heart failure with mildly reduced ejection fraction (HFmrEF) patients. This study was to evaluate the predictive value of VMT score for 1‐year all‐cause and cardiovascular disease (CVD)‐cause mortality in HFmrEF patients.MethodsThis cohort study enrolled 379 patients aged ≥18 years old with HFmrEF. Univariable and multivariable Cox regression analysis was employed to assess the association between VMT score and all‐cause or CVD‐cause mortality in HFmrEF patients. Hazards ratio (HR), and 95% confidence interval (CI) were effect sizes. Kaplan–Meier curves showed the survival probability of patients. The area under the curve (AUC) evaluated the prognostic value of the VMT score.ResultsThe risk of all‐cause mortality was increased in HFmrEF patients in the VMT score of 2 (HR = 2.80, 95%CI: 1.04–7.52) and 3 (HR = 4.29, 95%CI: 1.58–11.66). The VMT score of 3 was associated with an increased risk of 1‐year CVD‐cause mortality in patients with HFmrEF (HR = 7.63, 95%CI: 1.70–34.33). The AUC of VMT score for predicting 1‐year all‐cause mortality of HFmrEF patients was 0.724, and for predicting 1‐year CVD‐cause mortality of HFmrEF patients was 0.748. The survival probability of patients with the VMT score < 2 was higher than those with the VMT score of 2 and 3.ConclusionThe VMT score might be a reliable prognostic index for 1‐year all‐cause or CVD‐cause mortality of HFmrEF patients.
Prognostic significance of IL‐18 in acute coronary syndrome patients
Authors: Xiong Chenchun , Yu Qiaoting , Gao Feng , Liu Song , Zhang Jianhui , Ma Tianyi , Liu Suifeng 
Published: January 2024

AbstractBackgroundAfter acute coronary syndrome (ACS), inflammation aids healing but may harm the heart. Interleukin (IL)‐18 and IL‐1β are pivotal proinflammatory cytokines released during pyroptosis, a process that initiates and sustains inflammation. This study aimed to evaluate the levels of circulating IL‐18 and IL‐1β during the progression of ACS and to determine their association with subsequent clinical events in ACS patients.HypothesisCirculating levels of IL‐18 and IL‐1β are associated with subsequent clinical events in ACS patients.MethodsEmploying immunoassays, we examined plasma levels of IL‐1β and IL‐18 in 159 ACS patients and matched them with 159 healthy controls. The primary composite endpoint included recurrent unstable angina, myocardial infarction, heart failure exacerbation, stroke, or cardiovascular death.ResultsACS patients exhibited a significant increase in plasma IL‐18 levels, measuring 6.36 [4.46−9.88] × 102 pg/mL, in contrast to the control group with levels at 4.04 [3.21−4.94] × 102 pg/mL (p < 0.001). Conversely, plasma levels of IL‐1β remained unchanged compared to the control group. Following a 25‐month follow‐up, IL‐18 levels exceeding the median remained an important prognostic factor for adverse clinical events in ACS patients (hazard ratio = 2.37, 95% confidence interval: 1.14−4.91, p = 0.021). Besides, IL‐18 displayed a nonlinear association with adverse clinical events (p nonlinear = 0.044). Subgroup analysis revealed that the correlation between IL‐18 and the risk of adverse clinical events was not significantly affected by factors such as age, sex, history of diabetes, smoking, Gensini score, or ACS type (all p interaction >0.05).ConclusionIL‐18 appears to hold potential as a predictive marker for anticipating clinical outcomes in patients with ACS.
Single axonal characterization of trigeminocerebellar projection patterns in the mouse
Authors: Wang Tianzhuo , Numata Naoyuki , Ji Qing , Mizuno Yuma , Viet Nguyen‐Minh , Luo Yuanjun , Chao Yuhan , Panezai Saddam Khan , Sugihara Izumi 
Published: January 2024

AbstractThe cerebellar projection from the trigeminal nuclear complex is one of the major populations of the cerebellar inputs. Although this projection is essential in cerebellar functional processing and organization, its morphological organization has not been systematically clarified. The present study addressed this issue by lobule‐specific retrograde neuronal labeling and single axonal reconstruction with anterograde labeling. The cerebellar projection arose mainly from the interpolaris subdivision of the spinal trigeminal nucleus (Sp5I) and the principal trigeminal sensory nucleus (Pr5). Although crus II, paramedian lobule, lobule IX, and simple lobule were the major targets, paraflocculus, and other lobules received some projections. Reconstructed single trigeminocerebellar axons showed 77.8 mossy fiber terminals on average often in multiple lobules but no nuclear collaterals. More terminals were located in zebrin‐negative or lightly‐positive compartments than in zebrin‐positive compartments. While Pr5 axons predominantly projected to ipsilateral crus II, Sp5I axons projected either predominantly to crus II and paramedian lobule often bilaterally, or predominantly to lobule IX always ipsilaterally. Lobule IX‐predominant‐type Sp5I neurons specifically expressed Gpr26. Gpr26‐tagged neuronal labeling produced a peculiar mossy fiber distribution, which was dense in the dorsolateral lobule IX and extending transversely to the dorsal median apex in lobule IX. The projection to the cerebellar nuclei was observed in collaterals of ascending Sp5I axons that project to the diencephalon. In sum, multiple populations of trigeminocerebellar projections showed divergent projections to cerebellar lobules. The projection was generally complementary with the pontine projection and partly matched with the reported orofacial receptive field arrangement.
2,3‐Dichloroanthracene crystal, a new rigid matrix for single molecule optical investigations
Authors: Banasiewicz Marzena , Deperasińska Irena , Gawryś Paweł , Suwińska Kinga , Kozankiewicz Bolesław 
Published: January 2024

AbstractAbsorption and emission spectra of single crystals of 2,3‐dichloroathracene (23DCA) and 23DCA dispersed in n‐nonane matrix were studied at 5 K. Singlet and triplet excitonic bands in the crystal were estimated to be at about 415 nm and at wavelengths shorter than 700 nm, respectively. Thus, from the spectroscopic point of view, these crystals satisfy all criteria for a transparent and rigid matrix for low temperature optical studies of single molecules of dibenzoterrylene, which have their purely electronic S0→S1 transition at around 785 nm. Quantum‐chemistry calculations were used to analyze the spectra.
An Exploration of Substituent Effects on the Photophysical Properties of Monobenzopentalenes
Authors: Gazdag Tamás , Meiszter Enikő , Mayer Péter J. , Holczbauer Tamás , Ottosson Henrik , Maurer Andrew B. , Abrahamsson Maria , London Gábor 
Published: January 2024

AbstractMonobenzopentalenes have received moderate attention compared to dibenzopentalenes, yet their accessibility as stable, non‐symmetric structures with diverse substituents could be interesting for materials applications, including molecular photonics. Recently, monobenzopentalene was considered computationally as a potential chromophore for singlet fission (SF) photovoltaics. To advance this compound class towards photonics applications, the excited state energetics must be characterized, computationally and experimentally. In this report we synthesized a series of stable substituted monobenzopentalenes and provided the first experimental exploration of their photophysical properties. Structural and opto‐electronic characterization revealed that all derivatives showed 1H NMR shifts in the olefinic region, bond length alternation in the pentalene unit, low‐intensity absorptions reflecting the ground‐state antiaromatic character and in turn the symmetry forbidden HOMO‐to‐LUMO transitions of ~2 eV and redox amphotericity. This was also supported by computed aromaticity indices (NICS, ACID, HOMA). Accordingly, substituents did not affect the fulfilment of the energetic criterion of SF, as the computed excited‐state energy levels satisfied the required E(S1)/E(T1)>2 relationship. Further spectroscopic measurements revealed a concentration dependent quenching of the excited state and population of the S2 state on the nanosecond timescale, providing initial evidence for unusual photophysics and an alternative entry point for singlet fission with monobenzopentalenes.
MSeqDR Quick‐Mitome (QM): Combining Phenotype‐Guided Variant Interpretation and Machine Learning Classifiers to Aid Primary Mitochondrial Disease Genetic Diagnosis
Authors: Shen Lishuang , Falk Marni J. , Gai Xiaowu 
Published: January 2024

AbstractThe international Mitochondrial Disease Sequence Data Resource Consortium (MSeqDR) Quick‐Mitome (QM) is a web‐based platform enabling automated variant interpretation of whole‐exome sequencing (WES) datasets for the genetic diagnosis of primary mitochondrial diseases (PMD). Designed specifically to address the unique dual genome nature of PMD etiologies, QM includes features for both nuclear and mitochondrial DNA (mtDNA) genome analysis. QM requires VCF variant lists, HPO ID clinical phenotypes, and pedigree files for multiple‐sample VCF inputs. QM maps phenotypes to HPO terms before analysis. QM analysis requires 2 to 20 min for 100,000 variants on an 8‐vCPU AWS server using Exomiser's “PASS_ONLY” mode for nuclear variants. QM ranks variants based on allele frequency, phenotype‐gene association, functional impact, and inheritance mode. Variants are further annotated with multiple data sources such as OMIM, ClinVar, dbNSFP, gnoMAD, MITOMAP, and MSeqDR. In addition to standard Exomiser results, QM generates an Analysis Report and QM Integrated Report with add‐on mtDNA‐specific analyses, including haplogroup prediction with Phy‐Mer, heteroplasmy calculation, and mvTool annotations. We developed the Mitochondrial Disease Variant (MDV) classifier using XGBoost to predict variant pathogenicity for PMD. The MDV classifier was trained on >120 features and performance benchmarking showed that it correctly classified >98% of nuclear gene variants as being pathogenic or benign, and predicted PMD‐causing variants with 94% precision. The MSeqDR QM server is an open‐access resource for phenotype‐driven dual‐genome analyses for PMD diagnosis by the global mitochondrial disease community. It is publicly available for non‐commercial, non‐clinical research use at https://mseqdr.org/quickmitome.php. © 2024 Wiley Periodicals LLC.Basic Protocol 1: Standardizing clinical phenotypes into human phenotype ontology (HPO) terms as the phenotype input for Quick‐Mitome (QM)Basic Protocol 2: Prepare the pedigree input for multiple‐sample VCFBasic Protocol 3: Quick‐Mitome (QM) analysisBasic Protocol 4: Reviewing and understanding the QM Integrated Report and Analysis Report
Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy
Authors: Sosnowski David W. , Rojo‐Wissar Darlynn M. , Peng Gang , Parade Stephanie H. , Sharkey Katherine , Hoyo Cathrine , Murphy Susan K. , Hernandez Raquel G. , Johnson Sara B. 
Published: January 2024

AbstractMaternal exposure to childhood adversity is associated with detrimental health outcomes throughout the life span and may have implications for offspring. Evidence links maternal adverse childhood experiences (ACEs) to detrimental birth outcomes, yet the impact on the infant's epigenome is unclear. Moreover, maternal sleep habits during pregnancy may influence this association. Here, we explore whether restless sleep during pregnancy moderates the association between exposure to maternal childhood adversity and infant epigenetic age acceleration in 332 mother–infant dyads (56% female; 39% Black; 25% Hispanic). During the second trimester, mothers self‐reported childhood adversity and past‐week restless sleep; DNA methylation from umbilical vein endothelial cells was used to estimate five epigenetic clocks. Multivariable linear regression was used to test study hypotheses. Despite no evidence of main effects, there was evidence of an interaction between maternal ACEs and restless sleep in predicting infant epigenetic age acceleration using the EPIC gestational age clock. Only infants whose mothers reported exposure to both ACEs and restless sleep demonstrated accelerated epigenetic aging. Results provide preliminary evidence that maternal childhood adversity and sleep may influence the infant epigenome.
Riffle algal and macroinvertebrate recovery from wet‐season flood disturbance in a tropical savannah river, Northern Australia
Authors: Townsend Simon 
Published: January 2024

AbstractSuccession occurs when river biota recovers from the loss of biomass and diversity caused by flood disturbance, and has rarely been examined in the tropical savannah biome. Hypotheses are tested which address the environmental context and recovery of riffle macroinvertebrates in an Australian perennial, tropical savannah river, located in a catchment with low anthropogenic impact. Recovery occurred over a 32‐week dry‐season period of gradually declining discharge with near‐stable water quality, after a 23‐week wet‐season flood‐disturbance period, which was typical of the river's flow regime. Prolonged, benign environmental conditions during recovery facilitated the accrual of macroalgae. Macroinvertebrate abundance, mediated by macroalgal biomass, and diversity increased at a logarithmic, asymptotic rate over the recovery period. Macroinvertebrate assemblages and functional feeding groups (FFGs) tended to become more similar between consecutive sample dates as recovery progressed, though with variable abundances of core taxa (Orthocladiinae, Hydropsychidae, Orthotrichia, Chironominae and Pyralidae) and prominence of Hydroptila late in the recovery period. Filterer abundances fluctuated most, whilst the relative abundance of herbivorous shredders and predators generally increased. The return of macroinvertebrate abundance and diversity to its pre‐disturbance state is attributed to the similar pre‐ and post‐disturbance environmental conditions. Recovery broadly agreed with the secondary succession paradigm for macroinvertebrates. Macroinvertebrate succession was probably driven mainly by biotic factors, after the initial colonisation period. However, this requires elucidation and expansion of the current paradigm of river benthic succession from flood disturbance to address macroinvertebrate population dynamics under benign abiotic environmental conditions.
Hydrodynamic modelling to assess habitat suitability of the Ganga River dolphins
Authors: Kailash Sonkar Gaurav , Gaurav Kumar , Kumar Vaibhav , Beg Zafar 
Published: January 2024

AbstractThe Ganga River hosts a metapopulation of endangered aquatic species. This study uses a hydrodynamic model (HEC‐RAS) to assess the habitat suitability of the Ganga River dolphins (GRDs) in a small reach (7.5 km) of the Ganga River at the upstream of Narora barrage in varying flow. We use Lidar points clouds to generate topography, Acoustic Doppler Current Profiler (ADCP), and differential GPS (DGPS) to measure channel bathymetry and streamwise water surface slope. Further, the water level data from satellite altimeter is used to calibrate the model and discharge measured in field to validate the model output. We found that in the high flow period, the required flow depth for dolphin habitat is available throughout in the study reach. However, in the lean flow, the required flow depth and velocity are available only in some patches. The methodology developed here would be very useful in monitoring hydraulic habitat suitability of aquatic species in ungauged rivers.
Composition of fatty acids in a high‐fat diet affects adipose tissue inflammation by inducing calreticulin on adipocytes and activating group 1 innate lymphoid cells
Authors: Matsumura Kazunori , Mori Taizo , Dohi Taeko , Kawamura Yuki I. , Takaki Satoshi 
Published: January 2024

AbstractObesity‐induced adipose tissue inflammation plays a critical role in the development of metabolic diseases. For example, NK1.1+ group 1 innate lymphoid cells (G1‐ILCs) in adipose tissues are activated in the early stages of inflammation in response to a high‐fat diet (HFD). In this study, we examined whether the composition of fatty acids affected adipose inflammatory responses induced by an HFD. Mice were fed a stearic acid (C18:0)‐rich HFD (HFD‐S) or a linoleic acid (C18:2)‐rich HFD (HFD‐L). HFD‐L‐fed mice showed significant obesity compared with HFD‐S‐fed mice. Visceral and subcutaneous fat pads were enlarged and contained more NK1.1+KLRG1+ cells, indicating that G1‐ILCs were activated in HFD‐L‐fed mice. We examined early changes in adipose tissues during the first week of HFD intake, and found that mice fed HFD‐L showed increased levels of NK1.1+CD11b+KLRG1+ cells in adipose tissues. In adipose tissue culture, addition of 4‐hydroxynonenal, the most frequent product of lipid peroxidation derived from unsaturated fatty acids, induced NK1.1+CD11b+CD27− cells. We found that calreticulin, a ligand for the NK activating receptor, was induced on the surface of adipocytes after exposure to 4‐hydroxynonenal or a 1‐week feeding with HFD‐L. Thus, excess fatty acid intake and the activation of G1‐ILCs initiate and/or modify adipose inflammation.
Successive magnetic transitions and frustrated magnetism in Fe2(HPO3)3 ⋅ 4H2O
Authors: Cheng Xiaomeng , Lv Chengxiang , Zhang Shufang , Ding Mingcui , Pan Bingying 
Published: January 2024

AbstractWe report the magnetic and optical properties of Fe2(HPO3)3 ⋅ 4H2O. By combined magnetic susceptibility and specific heat measurements, we find two antiferromagnetic (AFM) transitions (TN1=9 K, TN2=5 K) which originate from the AFM exchange interactions mediated by the (HPO3)2− anions. Compared with the non‐hydrated compound Fe2(HPO3)3, the magnetic interaction strength and ordering temperature of Fe2(HPO3)3 ⋅ 4H2O are both reduced by a factor of ~2. Through density functional theory (DFT) analysis we find almost degenerate AFM states in Fe2(HPO3)3 ⋅ 4H2O which are close in energy. The competition of these AFM states might lead to the two successive AFM phase transitions at low temperature. The low ordering temperature as well as competing AFM states both imply frustrated magnetism in Fe2(HPO3)3 ⋅ 4H2O, probably originating from the complex competing AFM interactions. The optical properties of Fe2(HPO3)3 ⋅ 4H2O are also investigated by photoluminescence and infrared spectroscopies.
Revaluation process of cheese whey through the cultivation of black soldier fly larvae (Hermetia illucens)
Authors: Caltzontzin‐Rabell Valeria , Escobar‐Ortiz Alexandro , Gutiérrez‐Antonio Claudia , Feregrino‐Pérez Ana Angélica , García‐Trejo Juan Fernando 
Published: January 2024

AbstractOrganic wastes, including cheese whey, are generated in greater quantities each year, which require management that has economic and social implications. Current treatments of cheese whey do not allow for its complete degradation or utilization. In this context, black soldier fly larvae (BSFL) promise to degrade a variety of wastes while generating and accumulating value‐added products such as protein, fat that can be transformed into biodiesel, and fertilizer can be obtained from their residues. In this work, the aim was to evaluate the cultivation of BSFL as a biological treatment for the revaluation process of cheese whey, as well as the composition of the larvae and residue (FRASS) obtained for the subsequent extraction of value‐added products such as fat or protein. It was observed that cheese whey did not affect the growth of the larvae, on the contrary, it increased it (final weight of = 0.252 ± 0.003 g). The larvae biomass was composed of mainly of lipids (42.48 ± 1.26% dry matter) and protein (34.98 ± 0.72% dry matter). A fatty acid profile was also performed, which confirms that, due to their composition (Saturated fatty acids = 262.91 ± 34.81 mg/g; monounsaturated fatty acids = 85.29 ± 19.64 mg/g; polyunsaturated fatty acids = 63.68 ± 11.33 mg/g), these accumulated lipids can be extracted for biodiesel production. This is the first approach to the treatment and utilization of cheese whey through insects.