bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microvasculature alterations of peripapillary retina and macula in systemic lupus erythematosus patients without ocular involvement by optical coherence tomography angiography
Authors: Li Huangdong , Yu ShuiLian , Li Peiyi , Zhang Jingyu , Maitiyaer Maierhaba , Huang Amy Michelle , Deng Qian , Yang Ruiming , Liang Jiamian , Huang Wenhui , Liu Zhiping 
Published: November 2023

Abstract

Purpose:
To evaluate microvasculature alterations of the peripapillary retina (PR) and macula and to assess if the changes can detect preclinical retinopathy in systemic lupus erythematosus (SLE) patients.

Methods:
Cross-sectional study of 32 SLE patients without retinopathy and 22 normal controls. Optical coherence tomography angiography was used to measure the microvasculature of the PR and macula. Vessel densities (VD, %) and fractal dimensions of superficial capillary plexus (SCP) and deep capillary plexus (DCP) were calculated.

Results:
Compared to controls, macular VD of the whole image SCP (mVD of SCP-wi) and mVD of inferior SCP (mVD of SCP-i) were significantly reduced in SLE patients (p<0.05). The peripapillary VD (pVD) of a 2.5mm circle of SCP (pVD of SCPΦ2.5), pVD of SCPΦ3.5, and pVD of inferior region of the inner circle of SCP (pVD of SCP-ii) were significantly reduced in patients treated with hydroxychloroquine (HCQ) >5 years. mVD of SCP-wi declined with age (β=-0.12; p<0.01) and pVD of SCP-ii declined with hydroxychloroquine cumulative dose (β=-0.01; p<0.01). mVD of SCP-i had the best discrimination power of 0.77 (p<0.01).

Conclusion:
SLE patients without ocular involvement had microvasculature alterations that were particularly evident in the SCP. PR microvasculature may be reduced in patients with longer HCQ treatment.
Association of Diabetic Macular Edema with Quality of Life in Type 2 diabetes patients: The Fushun Diabetic Retinopathy Cohort Study
Authors: Zang Bo , Rong Shisong , Wang Yu , Feng Kemi , Ding Xiaoxia , Wen Liang , Zang Dongxiao , Li Dong , Liang Yuanbo , Wang Fenghua , Zhai Gang 
Published: November 2023

Abstract

Purpose:
To report the vision-related quality of life (VRQoL) in patients with diabetic macular edema (DME) in a population-based study.

Methods:
In this cross-sectional study, we analyzed 1659 subjects with type 2 diabetes. Questionnaires were administered to assess the patient’s VRQoL. DME severity was graded according to established protocols. A subject’s DME score ranged from 1 (no DME in either eye) to 7 (severe bilateral DME) using predefined criteria.

Results:
Composite NEI-VFQ-25 scores for participants with DME were 88.9 (interquartile range [IQR]: 76.2, 94.9), compared to 92.0 (IQR: 82.7, 96.0) for those without DME (P < 0.001). Locally weighted scatterplot smoothing (LOWESS) plots depicted a consistent decline in composite NEI-VFQ-25 scores corresponding to the escalation of bilateral DME severity: starting from 88.59 for no DME in either eye, progressing through 86.65, 85.83, 85.31, 84.91, 83.85, and culminating at 82.71 for bilateral severe DME. Notably, the LOWESS plots highlighted significant NEI-VFQ-25 composite score reduction at unilateral mild DME (slope m= -1.94).

Conclusion:
Significant changes in VRQoL manifest in the early stage of DME. Therefore, early identification and intervention for these patients are crucial clinical objectives.
Short-Term Efficacy and Safety of Phacoemulsification Associated With iStent Inject W in Patients With Controlled Open Angle Glaucoma
Authors: Louanchi Yanis , Brasnu Emmanuelle , Hamard Pascale , Aragno Vittoria , Baudouin Christophe , Labbé Antoine 
Published: November 2023

Précis:
The iStent inject W implanted during phacoemulsification effectively reduces IOP.

Purpose:
The purpose of this study was to evaluate the efficacy and safety of iStent inject W combined with phacoemulsification in patients with controlled open angle glaucoma undergoing cataract surgery.

Patients and Methods:
We conducted a retrospective, bicentric study of patients with controlled chronic open angle glaucoma who underwent phacoemulsification combined with the injection of 2 iStent inject Ws. Patient characteristics, including intraocular pressure (IOP) and the number of glaucoma medications, were evaluated preoperatively and 1 week, 1 month, and 6 months postoperatively. The primary end point was IOP reduction, and the secondary end point was the reduction in the number of glaucoma medications.

Results:
In this study, 85 eyes were included. The majority of patients had primary open angle glaucoma (85% of eyes). Preoperative mean IOP was 16.1±2.0 mm Hg with a mean of 2.3±0.5 glaucoma medications. At 1 week postoperatively, the mean IOP was 16.7±3.1 mm Hg with a mean of 2.0±0.7 hypotensive medications. At 1 and 6 months, the mean IOP was 14.2±2.1 and 13.0±1.5 mm Hg, with a mean of 2.0±0.6 and 1.8±0.5 glaucoma medications, respectively. The percentage IOP reduction at 1 and 6 months was 11.6% (P=0.001) and 19.3% (P<0.0001), respectively. Regarding glaucoma medications, at 1 and 6 months, the reduction in the number of medications was 12.9% (P=0.025) and 22.4% (P=0.003), respectively. The most frequent significant postoperative adverse events were corneal edema in 7%, IOP spikes in 6%, and hyphema in 6% of eyes, which resolved spontaneously.

Conclusions:
The iStent inject W implanted during phacoemulsification effectively reduces IOP and the number of glaucoma medications needed at 6 months of follow-up, with a favorable safety profile in patients with controlled open angle glaucoma.
Predictors of Sun-Protective Behaviors and Sunburn in the United States Population
Authors: Ward Jeanne , Sha Shuying , Hardin-Fanning Frances 
Published: November 2023

ABSTRACT
Skin cancer is the most diagnosed cancer in the United States. Despite years of education about prevention, incidence is increasing. There are mixed findings about sun protection factors' relationship to preventing sunburn. This study aimed to identify the factors associated with the performance of sun-protective behaviors and understand sunburn risk factors, which relate to skin cancer risk, controlling for demographic factors. This is a secondary analysis of cross-sectional data from the National Health and Nutrition Examination Survey from 2017 to 2018. Data were subset to U.S. participants ages 20 years and older who answered the dermatology questions, which included 3,404 people. A hierarchical logistic regression analysis was conducted in SPSS to investigate the contribution of several factors predicting sun-protective behaviors while controlling for demographic variables. In addition, multiple logistic regression analyses were used to examine potential factors related to getting a sunburn. Statistical significance was p < .05. Race, education, birth country, gender, and sun sensitivity were significant predictors of sun protection behaviors. Those who used sunscreen with a higher frequency and those with severe sun sensitivity had the highest odds of reporting a sunburn. Younger age and severe sun sensitivity were associated with multiple sunburns. The discrepancy between the perceived level of sun sensitivity and the incidence of sunburn suggests that people need to be adequately informed about the risks of sunburn. This finding supports the need for additional research to understand the attitudes and health beliefs toward sunburn and skin cancer prevention.
The potential role of social care in reducing childhood obesity
Authors: Cruz Herrera Evianna , Figueroa-Nieves Amanda I. , Woo Baidal Jennifer A. 
Published: November 2023

Purpose of reviewThis review evaluates the current evidence for relationships of social factors with childhood obesity and for a role of social care in reduction of childhood obesity.Recent findingsMost literature on the relationship between social factors and childhood obesity has examined food insecurity as a risk factor for obesity. Associations between food insecurity and excess weight in children are most consistent during infancy and among those with food insecurity at more than one time point. A few pilot food security interventions that link patients with produce or groceries show feasibility and potential promise for reducing childhood obesity risk factors. However, full-scale, randomized studies to examine interventions that reduce social needs and their effects on childhood obesity are lacking. Future research is needed to examine holistic social care approaches to effectively reduce childhood obesity risk factors.SummaryFood insecurity acts as a barrier to childhood obesity prevention and treatment. Patient-centered, validated measures of social needs and effective interventions to address social needs are needed to equitably prevent and treat childhood obesity.
Long-term outcome of centrally located hepatocellular carcinoma treated by neoadjuvant radiotherapy and radical resection: a propensity score matched study
Authors: Tao Changcheng , Wu Fan , Liu Yue , Wang Liming , Wang Hongwei , Chen Bo , Rong Weiqi , Wu Jianxiong 
Published: November 2023

Objective:
Centrally located hepatocellular carcinoma (HCC) typically presents challenges in surgical intervention and is associated with a bleak prognosis. In order to address this pressing issue, it is imperative to identify a comprehensive treatment approach, such as neoadjuvant radiotherapy (neoRT), that can enhance the prognosis of patients diagnosed with centrally located HCC.

Methods:
Patients who had surgical resections for HCC between March 2015 and December 2020 were included in the study. Patients were assigned to either the neoRT combined with liver resection (neoRT+LR) group or the liver resection alone (LR) group. The study employed propensity-score analysis and Cox proportional-hazards regression models as research methodologies. Using the Kaplan–Meier method, overall survival (OS) and disease-free survival (DFS) were estimated in patients.

Results:
During the study, 162 patients were enrolled, with 41 receiving neoRT+LR and 121 receiving LR. The duration of the median follow-up period was 45 months. The 1-year, 3-year, and 5-year OS rates were 95, 70, and 70% for patients in the neoRT+LR group, and 82, 64, and 54% for patients in the LR group, respectively. The 1-year, 3-year, 5-year DFS rates were 71, 53, and 37% for patients in the neoRT+LR group, and 52, 38, and 34% for patients in the LR group, respectively. A successful matching of 37 patients was achieved through propensity-score analysis. OS and DFS after matching analysis was statistically different between the two groups ( P=0.0099, P=0.034, respectively). neoRT was an independent prognostic factor for OS and DFS [hazard ratio (HR)=0.47, 95% CI: 0.24–0.93; HR=0.56, 95% CI: 0.34–0.92, respectively]. According to matching analysis, there were no statistically significant differences observed in terms of baseline characteristics, surgical safety, and complications between the groups.

Conclusion:
Liver resection and neoRT can be advantageous for patients with centrally located HCC.
Is radiofrequency ablation effective in treating patients with chronic knee osteoarthritis? A meta-analysis of randomized controlled trials
Authors: Chen Bingkeng , Yang Yang , Wang Hui , Guo Xuefang , Wu Zhiqiang , Lan Zhibin 
Published: November 2023

Background and aims:This meta-analysis aimed to evaluate the short-term and long-term efficacy of radiofrequency ablation (RFA) and explore the role of diagnostic genicular nerve blocks in predicting treatment outcomes.Methods:A comprehensive literature search was conducted, and nine randomized controlled trials involving 714 participants were included in the analysis. Data extraction, risk of bias assessment, and subgroup analyses were performed. The primary outcome measures were pain scores at 6 and 12 months, assessed using visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.Results:The meta-analysis revealed that RFA demonstrated a significant short-term efficacy in reducing pain compared to the control group at 6 months, as indicated by the pain scores [weighted mean difference (WMD): −2.69, 95% CI: −3.99, −1.40]. Similarly, WOMAC scores at 6 months favored the RFA group (WMD: −4.40, 95% CI: −7.12, −1.68). However, the long-term efficacy of RFA at 12 months remained uncertain for both pain scores (WMD: −0.88, 95% CI: −2.36, 0.61) and WOMAC (WMD: 0.03, 95% CI: −0.25, 0.32). Subgroup analysis suggested that a positive result from the diagnostic genicular nerve blocks test was associated with a more favourable short-term outcome.Conclusion:This meta-analysis provides moderate-quality evidence supporting the short-term efficacy of RFA in reducing pain in patients with knee osteoarthritis. The inclusion of a diagnostic genicular nerve blocks test prior to RFA may help identify patients likely to benefit from the procedure. But it still needs more large sample studies to verify the results. However, further research is needed to determine the long-term efficacy of RFA in managing knee osteoarthritis pain.
Accuracy of imaging grading in comparison to open laminectomy to evaluate pedicle screws positioning
Authors: Rosa Filezio Marina , Peiro-Garcia Alejandro , Parsons David Llewellyn , Thomas Kenneth , Ferri-de-Barros Fabio 
Published: November 2023

Study design:
Prospective experimental study.

Objective:
To compare the accuracy of O-Arm-acquired radiographic and computed tomography (CT) evaluation of thoracic pedicle screw placement with open laminectomy in a simulation laboratory.

Summary of background data:
Improving surgical safety and procedural efficiency during thoracic posterior spine instrumentation is essential for decreasing complication rates and possible related risks. The most common way of verifying the position of pedicle screws during the surgical procedure and immediately postoperatively is to acquire intraoperative fluoroscopic images and plain radiographs of the spine, respectively. Laboratory simulated surgery is a valuable tool to evaluate the accuracy of those exams.

Methods:
Twenty simulation models of scoliosis from T3 to T7 were instrumented by five spine fellows (total of 200 pedicle screws), followed by radiographic and CT images acquired with the assistance of the O-Arm which were evaluated by three independent raters. A fellowship-trained spine neurosurgeon performed laminectomies on the instrumented levels and assessed pedicle integrity (gold standard).

Results:
Forty-eight breaches were identified in the axial direct view after laminectomy. Of those, eighteen breaches were classified as unacceptable. Regarding the sagittal direct view, four breaches were observed, three of which were classified as unacceptable. Overall, both O-arm radiographic and CT evaluations had a significantly high negative predicted value but a low positive predicted value to identify unacceptable breaches, especially in the sagittal plane. The frequency of missed breaches by all three examiners was high, particularly in the sagittal plane.

Conclusion:
Postoperative evaluation of pedicle screws using O-arm-acquired radiographic or CT images may underdiagnose the presence of breaches. In our study, sagittal breaches were more difficult to diagnose than axial breaches. Although most breaches do not have clinical repercussions, this study suggests that this modality of postoperative radiographic assessment may be inaccurate.

Level of evidence:
4.
Scope and Suction: Hysteroscopic-Guided Suction Evacuation of Cesarean Scar Pregnancy—A Safe and Efficacious Treatment for Selected Patients
Authors: Hameed Mohamed Siraj Shahul , Wright Ann , Chern Bernard Su Min 
Published: November 2023

(Abstracted from Gynecol Minim Invasive Ther 2023;12:72–76)
A continual rise of cesarean rates indicates a need to further study the possible development of lower uterine niches or cesarean scar defects, which can be described by adjacent myometrial thickness and residual myometrial thickness (RMT). Pregnancy complications such as placenta accreta spectrum disorders and uterine rupture are associated with RMTs of <2.2 mm.
Cost-Utility Analysis of Midurethral Sling Timing Among Women Undergoing Prolapse Surgery
Authors: Sassani Jessica C. , Giugale Lauren E. , Lavelle Erin Seifert , Shepherd Jonathan P. 
Published: November 2023

(Abstracted from Urogynecology 2023; doi: 10.1097/SPV.0000000000001384)
Approximately 25% of women in the United States are affected by pelvic floor disorders, with estimates pointing to a 50% increase in urinary incontinence prevalence and pelvic organ prolapse (POP) by 2050. Surgery for stress urinary incontinence (SUI) is also often required, which adds to economic burdens of pelvic floor disorders. Determining the POP patients who would benefit most from concomitant midurethral slings (MUSs) remains a clinical challenge.
Maternal and Fetal Cardiovascular Responses to Acute High-Intensity Interval and Moderate-Intensity Continuous Training Exercise During Pregnancy: A Randomized Crossover Trial
Authors: Wowdzia J. B. , Hazell T. J. , Vanden Berg E. R. , Labrecque L. , Brassard P. , Davenport M. H. 
Published: November 2023

(Abstracted from Sports Med 2023;53(9):1819–1833)
Current recommendations for exercise during pregnancy largely refer to moderate-intensity continuous training (MICT), which has been shown by many studies to be beneficial to both mother and fetus by reducing preeclampsia, gestational diabetes, and depression. Although MICT has been shown to be effective, only 15% of individuals meet the recommended 150-minutes-a-week threshold for MICT; many individuals report their main obstacle as lack of time.
Subtypes of complex regional pain syndrome—a systematic review of the literature
Authors: Knudsen Lone , Santoro Lana , Bruehl Stephen , Harden Norman , Brunner Florian 
Published: November 2023

Abstract
To systematically identify and summarize possible subtypes of complex regional pain syndrome (CRPS), we searched MEDLINE, Embase, Cochrane, Scopus, and Web of Science for original studies reporting or investigating at least one subtype within a group of patients with CRPS. The search retrieved 4239 potentially relevant references. Twenty-five studies met our inclusion criteria and were included in the analysis. Complex regional pain syndrome phenotypes were investigated based on the following variables: clinical presentation/sensory disturbances, dystonia, skin temperature, disease duration, onset type, CRPS outcome, and neuropsychological test performance. Support was found for the following CRPS subtypes: CRPS type I, CRPS type II, acute CRPS, chronic CRPS, centralized CRPS, cold CRPS, warm CRPS, inflammatory CRPS, dystonic CRPS, nondystonic CRPS, familial CRPS, and nonfamilial CRPS. It is unclear whether these are distinct or overlapping subtypes. The results of this comprehensive review can facilitate the formulation of well-defined CRPS subtypes based on presumed underlying mechanisms. Our findings provide a foundation for establishing and defining clinically meaningful CRPS subtypes, with the ultimate goal of developing targeted and enhanced treatments for CRPS.
Value of Quantitative Salivary Gland SPECT/CT for the Detection of Saliva Leakage
Authors: Kim Ji-Young , Kim Han Su , Kang Seo Young , Moon Byung Seok , Kim Bom Sahn , Yoon Hai-Jeon 
Published: November 2023

Abstract
A 47-year-old woman presented to our emergency department with a 10-day history of pain, halitosis, and swelling below the left jaw. The patient was diagnosed with left sialadenitis and left submandibular abscess by tissue biopsy. An otolaryngologist performed transcervical incision and drainage of the abscess 1 day after admission. Postoperatively, the patient complained of a sensation of fluid leakage from the mouth, and a continuous purulent discharge was observed. One month postoperatively, a salivary gland scan and SPECT/CT were performed to investigate the sialorrhea and the cause of the discharge. Salivary gland SPECT/CT images localized the saliva leakage site.
Incidental Tongue Cancer Detected With Total-Body 13N-NH3 PET/CT
Authors: Yu Xiaofeng , Xu Lian , Zhu Lijing , Liu Jianjun , Chen Yumei 
Published: November 2023

Abstract
A 68-year-old man with chest tightness underwent cardiac blood perfusion imaging on total-body 13N-NH3 PET/CT. Incidentally, mildly increased 13N-NH3 activity was observed in the left side of the body of the tongue. Pathological diagnosis proved to be mucosal squamous cell carcinoma.
Challenges in Managing Post-Radiation TMJ Pseudoankylosis
Authors: Bangun Kristaninta , Widayanti Nurina , Menna Clara 
Published: November 2023

This study demonstrates the outcomes of post-radiation temporomandibular joint (TMJ) pseudoankylosis management and its challenges. A rare maxillary squamous cell carcinoma was treated with subtotal maxillary resection. Subsequent radiation therapy, failure of free flap reconstruction, and 1 year of jaw hypomobility instigated TMJ pseudoankylosis with a maximal mouth opening (MMO) of less than 5 mm. Bilateral coronoidectomy was done simultaneously with maxillary reconstruction, followed up with buccal fibrosis release and extensive jaw exercises. At 16 months of follow-up, the patient’s MMO was 20 mm. Although bilateral coronoidectomy released the attachment of the atrophic temporalis muscle, it did not correct the other causes of trismus, specifically the progressive fibrosis of masticatory muscles, loss of elasticity of the TMJ ligaments, and other soft tissue abnormalities. Radiotherapy-induced–trismus refractory to physical exercise may require further management to achieve satisfactory MMO.
Suicidality and nonsuicidal self-injury in females diagnosed with attention-deficit hyperactivity disorder - a narrative review
Authors: Todzia-Kornaś Agata , Szczegielniak Anna , Gondek Tomasz M. 
Published: November 2023

Purpose of review
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder and is associated with an increased risk of suicidal behavior, especially in females. The differences in the presentation of ADHD in females, factors contributing to suicidality and the effects of therapeutic interventions are presented in this review to highlight the relationship between ADHD and suicidality and self-harm behavior.

Recent findings
Impulsivity, an inherent symptom of ADHD, commonly acts as a risk factor of suicidality and is associated with both suicidal behavior and nonsuicidal self-injury. The combined subtype of ADHD, which typically is characterized by significant impulsivity, is linked with the highest vulnerability to suicide attempts. Female gender, lower educational attainment, comorbid substance abuse, a history of depression, and experience of childhood maltreatment were singled out as distinct factors that were independently linked to lifetime suicide attempts.

Summary
The association of the ADHD and suicidality is gaining an increasing interest in recent years. Active suicide prevention is required in this population and it is crucial for clinicians and researchers to have access to the most current information in this field.