bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between cardiometabolic index and biological ageing among adults: a population-based study
Authors: Liu Na , Lin Yong 
Published: January 2024

Abstract
Background
Cardiovascular health (CVH) is closely associated with ageing. This study aimed to investigate the association between cardiometabolic index (CMI), a novel indicator of cardiometabolic status, and biological ageing.
Methods
Cross-sectional data were obtained from participants with comprehensive CMI and biological age data in the National Health and Nutrition Examination Survey from 2011 to 2018. Biological age acceleration (BioAgeAccel) was calculated as an ageing index using eight biomarkers. Weighted multivariable regression, sensitivity analysis, and smoothing curve fitting were performed to explore the independent association between CMI and the acceleration of biological age. Subgroup and interaction analyses were performed to investigate whether this association was consistent across populations.
Results
In 4282 subjects ≥ 20 years of age, there was a positive relationship between CMI and biological age. Each unit increase in CMI was associated with a 16% increase in biological age acceleration [1.16 (1.02, 1.31)] in the fully adjusted models. The participants in the highest CMI quartile had a 149% higher BioAgeAccel [2.49 (2.15, 2.83)] than those in the lowest CMI quartile. In stratified studies, the positive correlation between CMI and biological age acceleration remained consistent across strata. This positive correlation was stronger in female populations.
Conclusions
CMI is positively correlated with biological ageing in adults in the United States. Encouraging lower CMI levels may be advantageous in alleviating ageing.
Symmetrical Supercapacitor with Graphene-Supported Iron Hexacyanoferrate Electrodes: Wide Potential Window and High Energy Density
Authors: Junior Lindiomar Borges de Avila , Arambulo Pablo Cesar Serrano , Quispe Luis Torres , Dantas Adriana , Costa Diogo Pontes , Arizaca Edy E. Cuevas , Chávez Diana Patricia Paredes , Portugal Cesar Danial Valdivia , Müller Christian Klaus 
Published: January 2024

Abstract
In this work, iron hexacyanoferrate (FeHCF) particles have been grown onto graphene substrate through pulsed electrodeposition process. Thus, prepared FeHCF electrode exhibits volumetric capacitance of 88 F cm− 3 (a real capacitance of 26.6 mF cm− 2) and high cycling stability with capacitance retention of 93.7% under deep repeating of 10000 galvanostatic charge-discharge cycles in 1M KCl electrolyte. Furthermore, two identical FeHCF electrodes were paired up in order to construct a symmetrical supercapacitor, which delivers a wide potential window of 2 V in 1M KCl electrolyte, and demonstrates large energy density with an offer of high power density.
Changes in Diabetes Care and Management Practices during the COVID-19 Pandemic
Authors: Vashist Kushagra , Frediani Jennifer K. , Weber Mary Beth , Ali Mohammed K. , Narayan K. M. Venkat , Patel Shivani A. 
Published: January 2024

Abstract
Background
Evidence suggests diabetes management was negatively impacted early in the pandemic. However, the impact of the pandemic on key healthcare services for diabetes control and diabetes self-management practices is less known. We examined changes in diabetes care and management practices before and during the COVID-19 pandemic.
Methods
Population-based data regarding 4 diabetes-related healthcare engagement and 4 self-management indicators were obtained from adults with diabetes surveyed in 19 US States and Washington DC through the Behavioral Risk Factor Surveillance System. Using logistic regression, we estimated changes in the prevalence of each indicator, overall and by sociodemographic subgroups, before (2019; n = 15,307) and during (2021; n = 13,994) the COVID-19 pandemic.
Results
Between 2019 and 2021, the prevalence of biannual HbA1c tests reduced by 2.6 percentage points (pp, 95% CI :-4.8, -0.4), from 75.4–73.1%, and prevalence of annual eye exams fell by 4.0 pp (-6.2, -2.8), from 72.2–68.7%. The composite indicator of engagement with healthcare for diabetes control fell by 3.5 pp (-5.9, -1.1), from 44.9–41.9%. Reductions in engagement with healthcare were largely seen across sex, age, education, employment status, marital status, insurance status, and urbanicity; and were more pronounced among those aged 18–34 and the uninsured. Reductions in engagement with healthcare were seen in several states, with Delaware and Washington DC reporting the largest decrease. Of self-management behaviors, we only observed change in avoidance of smoking, an increase of 2.0 pp (0.4, 3.6) from 84.7–87.1%.
Conclusions
The pandemic had mixed impacts on diabetes care and self-management. The findings suggest a deterioration of the uptake of evidence-based, preventive health services requiring laboratory services and clinical examination for diabetes control during the pandemic. On the other hand, smoking rates decreased, suggesting potential positive impacts of the pandemic on health behaviors in people with diabetes.
MANTRA game analytics: Effectiveness of educational mobile game on knowledge gain and retention of Female Community Health Volunteers (FCHVs) and women in rural Nepal assessed through game analytics
Authors: Mueller Sonja , Stavrianaki Katerina , Boscor Andrei , Saville Naomi , Arjyal Abriti , Baral Sushil , Fordham Maureen , Hearn Gareth , Kostkova Patty 
Published: January 2024

Abstract
Background
Mobile technology can deliver public health interventions to reach remote populations such as unique mHealth interventions aimed at low-literacy audiences in low resource settings. This research study assessed a mobile phone-based serious game that teaches geohazard, maternal, and neonatal health messages. This study is part of the Maternal and Neonatal Technologies in Rural Areas (MANTRA) project: Increasing maternal and child health resilience before, during, and after disasters using mobile technology in Nepal.
Method
In this paper, we develop a novel games analytics method assessing the knowledge gain and retention by the participants using the in-app collected session data of ordered player responses to game questions as they play and progress through the game. For each learning objective in each level we compare our observations (the data gathered from the players and coded as described above) and the expected frequencies (the number we would have seen as observed if the null hypothesis is true) with a chi – squared hypothesis test. Finally the test statistic is used to find the p value and compared to p = 0.05.
Results
Knowledge gain and retention above 25% was calculated for 7 of 30 learning objectives. Results indicate only knowledge gained, so players answering correctly throughout the game are not the focus. In the maternal health module, a p value of < 0.05 was calculated for five learning objectives in level 1 and no significant learning objectives in level 2. The neonatal module level 1 had four learning objectives with significant results, and level 2 had three. The geohazards module showed the lowest significant results of the three modules, with only two significant learning objectives in level 2.
Conclusions
Analyzing the MANTRA mobile health game data showed several successful learning objectives across the three modules of maternal health, neonatal health, and geohazards. Success implies the learning objectives and game help participants gain and retain knowledge, while other learning objectives can be targeted for redesign.
The risk profiles of pregnancy-related intracranial venous thrombosis: a retrospective study in a comprehensive hospital
Authors: Wang Shaoying , Yao Ming , Hu Nan , Liu Juntao , Peng Bin 
Published: January 2024

Abstract
Objectives
To investigate the risk factors and underlying causes of pregnancy-related intracranial venous thrombosis (PCVT).
Methods
A retrospective cohort of 16 patients diagnosed with CVT during pregnancy and postpartum (within six weeks after delivery) in a comprehensive hospital in China between 2009 and 2022 were carefully reviewed, focusing on demographic, clinical, and etiological characteristics, especially underlying causes. We matched 16 PCVT patients with 64 pregnant and puerperal women without PCVT to explore risk factors and clinical susceptibility to PCVT.
Results
PCVT occurred commonly during the first trimester (43.75%) and the puerperium (37.5%). The frequency of anemia, thrombocytosis and thrombocytopenia during pregnancy, dehydration, and pre-pregnancy anemia was significantly higher in women with PCVT than in those without PCVT (P<0.05). Among the 16 patients, five were diagnosed with antiphospholipid syndrome and one were diagnosed with systemic lupus erythematosus. Three patients had distinct protein S deficiency and one had protein C deficiency. Whole Exome Sequencing (WES) was performed for five patients and revealed likely pathogenic mutations associated with CVT, including heterozygous PROC c.1218G > A (p. Met406Ile), heterozygous PROS1 c.301C > T (p. Arg101Cys), composite heterozygous mutation in the F8 gene (c.144-1259C > T; c.6724G > A (p. Val2242Met)) and homozygous MTHFR c.665C > T (p. Ala222Val).
Conclusions
The occur of anemia, thrombocytopenia and thrombocytosis during pregnancy, dehydration and pre-pregnancy anemia suggested a greater susceptibility to PCVT. For confirmed PCVT patients, autoimmune diseases, hereditary thrombophilia, and hematological disorders were common causes. Screening for potential etiologies should be paid more attention, as it has implications for treatment and long-term management.
A Bioinformatic Characterisation of the Glyolytic Enzyme ENO1 as a Biomarker of Breast Cancer Progression
Authors: Giannoudis Athina , Heath Alistair , Sharma Vijay 
Published: January 2024

Abstract
Enolase 1 (ENO1) catalyses glycolysis and is involved in the regulation of multiple signalling pathways. Utilising available online platforms (KM-plotter, ROC-plotter, cBioPortal, G-2-O, MethSurvand, TISIDB), we performed a bioinformatic analysis to establish the prognostic and predictive effects related to ENO1 expression in BC. A network analysis was performed using the Oncomine platform and signalling, epigenetic and immune regulation pathways were explored. ENO1 was overexpressed in all the analysed Oncomine, epigenetic and immune pathways in triple-negative, but not in hormone receptor-positive BCs. In HER2-positive BCs, ENO1 expression showed a mixed profile. Analysis on disease progression and histological types showed ENO1 overexpression in ductal in situ and invasive carcinoma, in high-grade tumours followed by advanced and/or metastasis and was linked to worse survival. High ENO1 expression was also associated with relapse-free, distant metastasis-free and overall survival, irrespectively of treatment and was mainly related to basal subtype. In conclusion, ENO1 overexpression recruits a range of signalling pathways during disease progression conferring a worse prognosis and can be potential utilised as a biomarker of disease progression and/or therapeutic target, particularly in triple-negative and in ductal invasive carcinomas.
Recommendation on Anemia Issue in Indonesia: Should Be More Meso and Macro Level Interest
Authors: makkiyah feda anisah , apriningsih apriningsih 
Published: January 2024

Abstract
Backgrounds. The prevalence of iron deficiency anemia among female adolescents in Indonesia is alarming. This issue has been brought to the forefront in recent publications, emphasizing the urgent need to combat this disease. The findings of this study will serve as a guide for policymakers and strategic interventions aimed at addressing this pressing concern.
Methods. Our team conducted an extensive bibliometric analysis on the prevalence of Anemia among teenage girls in Indonesia from 2010 to 2022. We used relevant keywords to extract published documents from Scopus and evaluated them. Additionally, we analyzed the data and identified trends using VOSviewer version 1.6.18. This tool enabled us to visually represent the publications based on the keywords, countries, and authors.
Results. The issue of Anemia among teenage girls in Indonesia was initially addressed by an author in 2014. Although it gained more attention in 2015, there were no further articles published on the subject by 2017. Roche M.L, a prominent author who focused on this theme, collaborated with other experts such as Mardewi, Raut MK, Zakaria A, Ekayanti, and others. The most searched keywords were divided into two main clusters.
Conclusion. Iron supplementation programs were initiated in 2014 due to regulations from the Indonesian Ministry of Health. However, it is concerning that current publications have primarily focused on micro-level perspectives, neglecting crucial meso and macro-level viewpoints. It is imperative that all levels of analysis are considered to ensure the success and effectiveness of these programs.
Preparation and Room Temperature Phosphorescent Properties of Cd(II) Homo- and Zn(II)Cd(II) Heterometallic Coordination Polymers Microstructures
Authors: Xu Mengxia , Wu Rao , Wang Shengqian , Xu Hualan , Zhong Shengliang 
Published: January 2024

Abstract

The preparation of coordination polymers with good room temperature phosphorescence is the focus of current research. In this paper, zinc and cadmium were used as metal ions and 2,3-pyridinedicarboxylic acid (2,3-H2pydc = 2,3-pyridinedicarboxylic acid) as organic ligands to successfully synthesize Cd(II) homo- and Zn(II)Cd(II) heterometallic coordination polymers microstructures. In addition, morphology, powder X-ray diffraction (PXRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA) and their luminescence properties were studied. Cd-CP is a micron-sized spherical structure, while Zn/Cd-CP is a flower-like structure formed by the accumulation of sheets. The results show that Cd(II) homo- and Zn(II)Cd(II) heterometallic coordination polymers have quantum yields of 10.05% and 8.54%, respectively. It is worth noting that the lifetime of Cd-CP is 124.62 ms, while the lifetime of Zn/Cd-CP is significantly extended to 363.09 ms after doping with metal ion Zn2+. The phosphorescent lifetime of coordination polymers was improved by the heterometallic doping strategy, which provided a new idea and method for the preparation of coordination polymers with long-lived room temperature phosphorescent properties. In addition, the two coordination polymers exhibited blue and cyan fluorescence at 365 nm UV light, respectively, and a green afterglow of about 2 seconds could be observed with the naked eye when the UV lamp was turned off.
Patient Satisfaction Following Trifocal Intraocular Lens Implantation with Phacoemulsification
Authors: Cleary Sean M. , Orgul Sarp , Crane Elliot S. , Schultze Robert L. 
Published: January 2024

Abstract
Purpose
To evaluate the rates of patient satisfaction following multifocal intraocular lens implantation with the PanOptix lens, and to identify pre- and post-operative patient characteristics that may predict future dissatisfaction.
Methods
This was a retrospective chart review study based in a private clinical practice in Albany, New York, USA. The first 78 consecutive trifocal intraocular implantations (PanOptix, Alcon) starting in 2019 were investigated. Exclusion criteria included subjects with less than one month of follow-up, or who did not respond to the post-operative survey. Data collection included refractive history, medical comorbidities, pre- and post-operative visual acuity, and refractive error. Subjective outcomes and satisfaction were assessed with patient phone calls.
Results
Of the 78 identified patients, 68 responded to the survey. 90% (61/68) of patients were satisfied with trifocal IOL Implantation. Pre-operatively, mean age, sex, pre-operative uncorrected and corrected distance visual acuity demonstrated no significant difference between satisfied and dissatisfied patients (P = 0.066, P = 0.69, P = 0.38, and P = 0.91 respectively). Dissatisfied patients had a significantly flatter mean pre-operative keratometry than satisfied patients (P = 0.049). Post-operatively, there was no significant difference in reported rates of bothersome glare/halos (P = 0.22). Unsatisfied patients had significantly higher rates of glasses use overall than satisfied patients (P = 0.002).
Conclusion
While patients are generally satisfied with their trifocal IOLs, flatter preoperative keratometry and greater cylinder on post-operative MRx correlates with greater dissatisfaction. Additionally, higher absolute and higher than expected rates of dependence on spectacle correction may play a larger role than dysphotopsia in satisfaction.
Increased blastomere number in D3 embryos is associated with higher live birth rates in vitrified– thawed single blastocyst transfer cycles
Authors: Zheng Weiwei , Lin Sheng , He Yichao , Han Lu , Cui Yuanyuan , Ma Congshun , Jiang Ronghua , Tan Yumei , Song Ge 
Published: January 2024

Abstract
Background The number of D3 embryo blastomeres affects pregnancy outcomes in patients undergoing cleavage-stage embryo transfer. However, the association between blastomere number in D3 embryos and pregnancy outcomes after vitrified–thawed single blastocyst transfer remains unknown.Methods This retrospective cohort follow-up study included 2,274 cases of vitrified–thawed single blastocyst transfer,all patients were divided into six groups according to blastomere number of D3 embryos: ≤5, 6, 7, 8, 9, and ≥ 10 cells. The primary outcome was the live birth rate (LBR). The secondary outcomes were the clinical pregnancy rate, miscarriage rate, and neonatal outcomes. Statistical analyses were performed using a multivariate logistic regression model to explore the association between blastomere number in D3 embryos and LBR.Results The LBR significantly increased with the number of blastomeres in D3 embryos (28.4%, 36.4%, 42.5%, 46.1%, 45.2%, and 58.1%; p < 0.001). Furthermore, the results of the high- and low-quality blastocyst subgroup analyses showed significant differences in the LBR among the groups (p < 0.01). As the number of blastomeres in D3 embryos increased, the miscarriage rate significantly decreased (23.3%, 18.6%, 14.0%, 15.9%, 13.6%, and 8.9%; p < 0.05). However, the number of blastomeres did not affect perinatal outcomes. Multivariate logistic regression analysis after adjusting for confounding factors revealed significantly decreased LBR in the ≤ 5-cell group (adjusted odds ratio [aOR]: 0.627, 95% confidence interval [CI]: 0.442–0.891; p < 0.01) and significantly increased LBR in the ≥ 10-cell group (aOR: 1.612, 95% CI: 1.230–2.112; p < 0.01) compared with that in the 8-cell group.Conclusions The number of blastomeres in D3 embryos may be an important factor in selecting blastocysts during vitrified–thawed single blastocyst transfer cycles. The transfer of a single blastocyst arising from ≥ 10-blastomere D3 embryo may reduce the miscarriage rate and improve LBR.
Learning symmetry-aware atom mapping in chemical reactions through deep graph matching
Authors: Astero Maryam , Rousu Juho 
Published: January 2024

Abstract

Accurate atom mapping, which establishes correspondences between atoms in reactants and products, is a crucial step in analyzing chemical reactions. In this paper, we present a novel end-to-end approach that formulates the atom mapping problem as a deep graph matching task. Our proposed model, AMNet (Atom Matching Network), utilizes molecular graph representations and employs various atom and bond features using graph neural networks to capture the intricate structural characteristics of molecules, ensuring precise atom correspondence predictions. Notably, AMNet incorporates the consideration of molecule symmetry, enhancing accuracy while simultaneously reducing computational complexity. The integration of the Weisfeiler-Lehman isomorphism test for symmetry identification refines the model's predictions. Furthermore, our model maps the entire atom in a chemical reaction, offering a comprehensive approach beyond focusing solely on the main molecules in reactions. We evaluated the performance of the model on a subset of USPTO reaction datasets, and the result reveals an average accuracy of 97.3% on mapped atoms and a top@10 accuracy of 99.7%, indicating 99.7% of reactions are correctly mapped when the correct mapped atom is in the first top 10 predicted atom.
Diversity-On: A diversity-sensitive online self-help program for family caregivers: A protocol for a mixed methods study
Authors: Annac Kübra , Basyigit Mualla , Öztürk Sümeyra , Örs Ela Rana , Aksakal Tugba , Kuhn Christina , Rutenkröger Anja , Tezcan-Güntekin Hürrem , Yilmaz-Aslan Yüce , Brzoska Patrick 
Published: January 2024

Abstract
Background
Scientific research has consistently emphasized the high levels of stress encountered by family caregivers of individuals living with dementia. However, conventional self-help approaches remain underused. The 'Diversity-On' study addresses this issue. Based on a storytelling approach, it develops and evaluates an online self-help program that is participatory and diversity-sensitive, ensuring congruence with diverse identities and lifeworlds.
Methods
The study uses a mixed-methods design, consisting of eight work packages. These comprise: (WP 1) the establishment of a council of family caregivers (N = 12) and an expert advisory board, (WP 2) secondary data analyses (N = 32), (WP 3) development and implementation of story boards, (WP 4) participant recruitment for the online support groups (N = 156), (WP 5) implementation of the intervention, (WP 6) process evaluation (N = 20), (WP 7) outcome evaluation (quantitative N = 130, qualitative: N = 20) and (WP 8) dissemination and validation of findings. The study's principal feature is its robust participatory strategy, incorporated across the research process and extending to all work packages. The study relies on partnerships with a broad range of stakeholders who unequivocally advocate for patient concerns.
Discussion
Given its participatory methodology and intersectional perspective, the ‘Diversity-On’ study is expected to yield several significant outcomes. It has the potential to empower family caregivers of individuals living with dementia who are under high stress, empowering them to take part in self-help ventures despite multiple barriers, thus easing their burden. Additionally, it has the capacity to safeguard the well-being of caregiving relatives who are overburdened by excessive demands. The study’s objective is to maintain home care arrangements for an extended period, in line with the values and aspirations of care recipients and their families. The study intends to develop and assess a precisely-customized online self-help resource, suitable for a diverse range of users, to remain accessible even beyond the study's duration.