bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological changes in the liver of rats under the influence of Vipera berus berus venom
Authors: Turbal L. V. , Yaremenko L. M. , Maievskyi O. Ye. 
Published: December 2023

Animal venoms contain a whole complex of compounds, among which there are peptides, proteins, as well as other organic molecules and salts. Their toxins are able to cause pronounced disturbances in the functioning of physiological systems, leading to the appearance of pathological conditions, complications, or even death. The aim of the research is to study the histological changes in the liver of rats under the influence of Vipera berus berus venom. Experimental studies were carried out on white non-linear male rats. The animals were conditionally divided into two groups – a control and an experimental group of 10 individuals in each. Experimental rats were injected intraperitoneally with a semi-lethal dose (LD50) (1.576 mg/g-1) of Vipera berus berus venom in saline solution. Animals of the control group were injected intraperitoneally with only saline solution. Rats were removed from the experiment 24 hours after exposure to the venom, anesthetized by cervical dislocation. Liver samples of animals of all groups were taken for microscopic examination. Histological preparations of the liver were stained with hematoxylin and eosin. Histological preparations were studied using a SEO SСAN light microscope. To identify the key enzyme of the citric acid cycle – succinate dehydrogenase, histochemical studies were performed according to the Nakhlas method. To study the features of glycogen accumulation in hepatocytes, sections were stained using Schiff's reagent, after pretreatment with iodic acid (PAS reaction) in Shabadash's modification. An immunohistochemical research method was used to detect a subpopulation of CD86+ cells in the liver of experimental animals. Under the influence of Vipera berus berus venom, the development of alterative changes in the liver parenchyma and vascular disorders were microscopically revealed. The appearance of foci of leukocyte infiltration was established, which indicates the development of inflammatory processes. A histochemical study of the content of succinate dehydrogenase in the liver of animals injected with Vipera berus berus venom showed uneven activity of the mitochondrial enzyme in the lobules. A histochemical study of glycogen in hepatocytes of the liver of rats exposed to Vipera berus berus venom showed a decrease in the content of trophic inclusions. An increase in the population of CD86+ cells indicates reactive inflammatory processes observed in the body as a result of the action of components of Vipera berus berus venom.
Paradoxical and Insufficient? Gender Quotas and Placement Mandates in Bosnia and Herzegovina’s 2020 Local Elections
Authors: Karic Mirsad , Aydin Šejma , Korkut Huseyin , Mulalić Muhidin 
Published: December 2023

Bosnia and Herzegovina is ranked 73rd in the Global Gender Gap Index 2022. A questionable democratisation process, ethnonationalism, and changes in the political culture strongly affected gender equality, participation, and representation in Bosnia and Herzegovina. This article tackles the impact of preferential voting on the representation of women in the local councils following the last Local Elections in Bosnia and Herzegovina. The effect of gender quotas and placement mandates are examined across the following determinants: electoral unit magnitude, local community urbanisation rate, ethnic composition of municipalities, and ideological foundation of political parties. To test the main objectives and research questions, this paper examines the impact of preferential voting on gender political representation. A complete dataset for all candidates and municipalities of the 2020 Local Elections, officially released by the State Election Commission, was used. The descriptive analysis indicates that 19.86% of women candidates have been elected to the local councils. With regards to the residence, female candidates from rural areas have a lower tendency of being elected than candidates from highly urban municipalities. Regarding ethnicity, the number of seats won by female candidates was the largest for candidates with a Serb majority, followed by the Bosniak and the Croat ones. When considering political orientation, female candidates from parties with centrist political orientation have a higher tendency of being elected, closely followed by female candidates from parties with a leftist orientation.
Keywords: Gender Gap; Preferential Voting; Representation; Electoral Systems; 2020 Local Elections; Bosnia and Herzegovina
УМАНСЬКА ОБОРОННА ОПЕРАЦІЯ В ІСТОРІЇ ДРУГОЇ СВІТОВОЇ ВІЙНИ
Authors: Священко Зінаїда 
Published: December 2023

У статті розглянуто передумови, перебіг та наслідки Уманської оборонної операції 1941 р., зроблено спробу з’ясувати її місце в подіях Другої світової війни.
Зроблено висновок, що важкі оборонні бої, які вели 6-а і 12-а армії спочатку в оперативному, а потім і в тактичному оточенні з кінця липня й до середини серпня 1941 р. були внеском у зрив гітлерівського плану «блискавичної війни», згідно з якими Україна мала бути завойована до початку липня 1941 р. Війська 6-ї і 12-ї армій на півмісяця затримали просування 22 дивізій вермахту та майже всіх військ сателітів. Без них німецьке командування не мало можливості успішно розвивати бойові дії в Україні. Стійкість та героїзм бійців та командирів 6-ї і 12-ї армій, по-перше, дали можливість організувати планомірну евакуацію з півдня України населення й промисловості, запасів продуктів харчування, скарбів музеїв, здійснити мобілізацію військовозобов'язаних на Правобережжі й організувати оборону Києва; по-друге, щит, що утворився з оточених у районі Умані військ, на певний час полегшив становище Південного та Південно-Західного фронтів, дав змогу іншим арміям закріпитися на нових рубежах.
Ключові слова: Друга світова війна, Уманська оборонна операція, 6-а і 12-а армії, оточення
З ІСТОРІЇ ДОСЛІДЖЕНЬ ТА МУЗЕЄФІКАЦІЇ КОМПЛЕКСІВ АРХЕОЛОГІЧНИХ ПАМЯТОК (ЗА МАТЕРІАЛАМИ БІЛЬСЬКА ТА ОЧАКOВА)
Authors: Біляєва Світлана , Куценко Сергій 
Published: December 2023

У статті на матеріалах різних за географічним розташуванням, природними регіонами та культурно-історичними складовими археологічних комплексів (пам’яток Більська та Очакова) представлено стислий огляд історії відкриття, основних етапів археологічних досліджень, особливостей музеєфікації та сучасного стану комплексів, що увійшли до переліку об’єктів національного значення. Визначено спільні риси в історії їх вивчення, підкреслено вагомий внесок Інституту археології НАН України, міжнародних проектів та роботу експедицій за участі провідних фахівців світового рівня, залучення науковців та студентів багатьох вузів ( практикантів та волонтерів), співробітників музеїв та пам’ятко охоронних організацій. Засвідчений приклад різних підходів до можливостей захисту, збереження та популяризації історико-культурної спадщини, позитивні та негативні факти у діяльності заповідників, до яких увійшли пам’ятки Більська та Очакова. Позначена роль місцевих громад та владних структур у підтримці охорони пам’яток історії та культури, розвитку туризму. Окреслено сучасне становище, у якому опинилися видатні комплекси історико-культурної спадщини, та наслідки російсько-української війни після повномасштабного вторгнення.
Ключові слова: Більський комплекс пам’яток, історичне місто Очаків, археологічні дослідження, музеєфікація, популяризація, історико-культурна спадщина.
Implementation of the Internet of Things in the Global Library Environment: Bibliometric Analysis
Authors: Borysov O. 
Published: December 2023

The relevance of the topic. Even though the potential of IoT in optimizing library processes and creating innovative services is meaningful, we can observe a lack of research focused precisely on the implementation and application of IoT in libraries. Studying IoT in the context of libraries requires an in-depth analysis and a systematic approach to expand the opportunities for developing recommendations and guidelines for library institutions.
The purpose of the article is to analyze bibliometric data obtained from the Scopus scientometric database concerning the application of Internet of Things technologies in library and information production.
The methodology of the research includes the methods of analyzing information regarding data obtained from the Scopus database and its generalization.
Conclusions. The analysis and systematization of data from the Scopus database showed that research focuses on innovative applications of IoT, data security, and library services’ development. The identified trends and dynamics of publications indicate that the role of IoT technologies in the modern library sector is persistently growing. Given the increasing number of publications from 2010 to 2022, a positive trend in the number of scientific studies in this area is expected, especially after the reduction of COVID-19 related quarantine restrictions. These conclusions can serve as a foundation for further research and the development of strategies for implementing IoT in libraries.
Scientific novelty of the paper is evident because no article containing the analysis of bibliometric data in the sphere of library industry has ever been published. These data were retrieved from the Scopus scientometric database concerning the application of the Internet of Things technologies in libraries worldwide.
Effects of Dexmedetomidine On the Postoperative Shivering, Nausea, and Vomiting Among Opium User Patients Undergoing Elective Supratentorial Brain Tumor Surgery: A Randomized, Placebo, Controlled Clinical trials
Authors: Rajabi Mona , Ommi Davood , Zali Alireza , Arefian Noor Mohammad 
Published: December 2023

Background: Postoperative nausea and vomiting (PONV), and shivering are common general anesthesia complications. Hence, this study evaluates the effect of dexmedetomidine, given as a premedication, on PONV and shivering in patients with opium use who underwent elective supratentorial brain tumor surgeries. Materials and Methods: In a randomized clinical trial, 100 opium user patients who were candidates for elective supra-tentorial brain tumor surgery under general anesthesia were studied in two groups of 50 patients. The intervention group received dexmedetomidine (within 10 and 30 minutes infusion) before the anesthesia induction. Group placebo that received normal saline as a group. PONV and shivering rates were compared between the two groups. Results: Both groups did not differ in hemodynamic parameters during operation, including pulse rate, systolic and diastolic blood pressure, and anesthesia duration. In the dexmedetomidine group, patients suffered less from PONV and shivering rather than controls, and these differences were both significant (P=0.001 and P=0.027, respectively). Discussion: Dexmedetomidine administration before major surgeries might reduce post-operative nausea and vomiting and the occurrence of shivering, particularly in opium-addicted patients.[GMJ.2021;10:e2146]
Immunology of stroke
Authors: Safari Anahid , Safari Rasool , Borhani-Haghighi Afshin 
Published: December 2023

Stroke, a multifactorial disease, has distinct pathophysiologic mechanisms, among which inflammation plays a pivotal role. Various types of inflammatory cells, substances, and molecules emerge in the ischemic stroke. Neutrophils, Tcell subtypes, macrophages, microglial cells, dendritic cell, mast cells, asrocytes, as influential cell,Â tumor necrosis factor_Î±, interleukin-17, interleukin-10, as released substances, andÂ vascular cell adhesion molecule-1 (VCAM-1), leukocyte very late antigen-4 (VLA-4), and glial fibrillary acidic protein (GFAP), as cellular adhesion molecules. Lymphocytes' invasion to the ischemic brain tissue occurs as the result of VLA-4Â Ì¶ VCAM-1 interaction. Regarding Tcell subtypes, CD4+ cells have known detrimental effects in the ischemic area, while natural killer T cells (NKT cells) and Î³Î´ T cells have minor importance in the early stage of ischemia. While some studies proved the cerebroprotective impact of T regulatory cells, others refuted this by presenting a prominent harmful role of them. Bcells have important protective function by releasing IL-10. Neutrophils along with microglial cell, appearing as the first inflammatory cell in the ischemic tissue, and also macrophages deteriorate ischemia. Mast cells and dendritic cells are of great value in stroke progression. The resting astrocytes are neuroprotective, whereas the activated ones present detrimental function in the ischemic region by expression of GFAP. Hence, stroke consequences occur as the result of systemic inflammatory response. The more activation of this system, the poorer neurological outcomes would be observed. As expected, anti-inflammatory interventions in the experimental stroke in animals, have revealed successful results as less infarct size and attenuated neurological damages.
Strategic Analysis of Shiraz Medical Tourism Industry: A Mixed Method Study
Authors: Rahimi Zarchi Mohammad Kazem , Jabbari Alireza , Hatam Nahid , Bastani Peivand , Shafaghat Tahereh , Fazelzadeh Omid 
Published: December 2023

Background: The connection between healthcare and tourism industries in many countries has created one of the largest service industries, i.e. "medical tourism industry". Medical tourism services bring significant benefits to the countries. Â This study aimed to examine internal and external factors affecting Shiraz medical tourism industry as well as the potential capabilities of the industry.Materials and Methods: This applied research is a mixed method study using both qualitative and quantitative methods in 2017. The study population consisted of all organizations involved in the medical tourism industry. In this study, the deductive qualitative content analysis was employed to determine the internal and external factors affecting Shiraz medical tourism industry. Furthermore, the SWOT technique was used to analyze the data obtained from individual interviews and meetings with expert panels. Results: Internal and external factors were classified into 4 main themes (namely strengths, weaknesses, opportunities and threats) and 10 sub-themes, of which five cases (FORMM) were related to internal factors (i.e. finance, production and products (operations), research and development, marketing and management) and five cases (STEPC) were associated with external factors including socio-cultural, technology, economy, political and competitive ones. Also, the matrix of the internal and external factors indicated an offensive zone for this industry. Conclusions: This industry can make use of the strengths and opportunities to confront the threats and negative points through identifying internal and external factors in order to enjoy benefits such as job creation and revenue gains. [GMJ.2018;7:e1021]
Effects Following Intracerebroventricular Injection of Immunosuppressant Cyclosporine A On Inhibitory Avoidance Learning and Memory in Mice
Authors: Banafshe Hamid Reza , Mohsenpour Mohsen , Ardjmand Abolfazl 
Published: December 2023

Background: Protein phosphatase-2B or calcineurin (CN) is the main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. Cyclosporine A(CyA), a phosphatase and peptidyl-prolyl cis/trans isomerase inhibitor, is a common immune suppressant extensively used in tissue transplantation. To further clarify the role of CN in different stages of learning and memory, the aim of the present study was to evaluate the role of CyA in an inhibitory avoidance (IA) model in mice.
Materials and Methods: Using intracerebroventricular (ICV) injection of different doses of CyA (0.5, 5, and 50 nM) at different periods (pre-/post-training and pre-test), the effect of the drug was evaluated in a step-down IA paradigm. The latency of step-down (sec) was considered a criterion for memory performance.
Results: The pre-training injections of CyA (0.5, 5 nM), however not of 50 nM, impaired IA learning acquisition. The post-training injection of high-dose CyA (50 nM) impaired memory consolidation. The pre-test ICV CyA injection did not impair memory retrieval; the ICV injection of CyA caused no change in locomotion.
Conclusion: These findings suggest that CyA selectively interferes with acquisition, retention, but not retrieval, of information processing in mice. Given the crucial role of CN in common signaling pathway of memory performance and cognition, it could be a probable therapeutic target in the treatment of a wide variety of neurological conditions involving memory. [GMJ.2018;7:e1044]
Exploring the Demographic Factors and Facilitators to Addiction Abstinence
Authors: Taghva Maryam , Shiraly Ramin , Moghimi Sarani Ebrahim 
Published: December 2023

Background: Accumulating evidence indicates a remarkable increase in substance addiction. Substance abuse and addiction impose severe social, political, economic, cultural and health-related damages on societies. Little is known, however, about demographic factors and facilitators to addiction abstinence. The purpose of the current study was to explore the factors associated with opioid avoidance.Materials and Methods: This cross-sectional study was performed to record socio-deÂ­mographic data and facilitating factors to abstinence in 600 interviews, according to data collecting forms, with patients who had drug abuse disorders at Shiraz city during 2016. Correlation test, T-test, and ANOVA were employed for data analysis. P<0.05 was considered as the significance level. Result: There was a significant difference between mean abstinence time and demographic factors such as age, sex, occupation and marital status. Also, 53% of people reported that they had the longest abstinence time using the narcotics anonymous (NA) method. TO 33% of patients, the most important facilitating factor in abstinence according to the patient's opinion was family support.Conclusion: Individual, social, psychosocial and medical variables affect the abstinence duration of substance abuse. Identifying the factors associated with longer abstinence can be helpful in designing prevention and treatment programs for variables that affect the recurrence.[GMJ.2018;7:e1074]
Transcultural Adaptation and Validation of Persian Version of Celiac Disease Questionnaire (CDQ); A Specific Questionnaire to Measure Quality of Life of Iranian Patients
Authors: Barzegar Farnoush , Pourhoseingholi Mohamad Amin , Rostami-Nejad Mohammad , Gholizadeh Sepideh , Malekpour Mohammad Reza , Sadeghi Amir , Rostami Kamran , Maleki Iradj , Shahbazi Shahin , Emami Mohammad Hassan , Asadzadeh-Aghdaei Hamid , Zali Mohammad Reza 
Published: December 2023

Background: The assessment of health-related quality of life has become an important primary or secondary outcome measure in clinical and epidemiologic studies. The aim of this study was to validate a Persian version of Celiac Disease Questionnaire (CDQ) for Celiac disease (CD) among Iranian patients. Materials and Methods: The English version of the CDQ adapted to the Persian language by a forward-backward translation by 3 professional bilingual translators (1 medical, 2 nonmedical). The content validity of translated questionnaire were studied by 5 experts who complete the validity form regarding the questionnaire. Then in a pilot study, translated CDQ completed by 81 CD patients who referred to Taleghani Hospital, Tehran. For assessing the validity and reliability of the questionnaire, confirmatory factor analysis and Cronbachâ€™s alpha coefficient have been done, using Lisrel and SPSS software. Results: Of 81 CD patients entered to this study with mean age of 30.54 years old, 71.6% were female. Also, 56.8% were married and 45.7% were high educated. The mean of CDQ total score was 119.18Â±34. The calculated Cronbachâ€™s alpha coefficient for CDQ questionnaire was 0.9. Also, for each subgroups the Cronbachâ€™s alpha coefficient were calculated as the following; emotion: 0.92, Social: 0.89, Worries: 0.73, Gastrointestinal: 0.78. Confirmatory factor analysis indicated that all questions could be remain in questionnaire respectively. Conclusion: The reliability of the Persian version of CDQ was excellent with Cronbachâ€™s alpha coefficients and Persian version of CDQ retains the psychometric properties of the original instrument and should be useful to assess outcome in studies and clinical trials involving Iranian patients with CD. [GMJ.2018;7:e1106]Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â
Role of the Zeta Method in Intracytoplasmic Sperm Injection Outcomes in High Sperm DNA Fragmentation in Oligoasthenozoospermic Men
Authors: SefidgarTehrani Maryam , Amirian Malihe , Jalali Mohsen , Attaranzadeh Armin , Fazel Alireza , Ebrahimzadeh-bideskan Alireza 
Published: December 2023

Background: New methods are needed to optimize intracytoplasmic sperm injection (ICSI) outcomes in oligoasthenozoospermic (OAS) men. We evaluated the level of DNA fragment index (DFI) in OAS men and its impact on ICSI outcomes. In addition, we used the zeta potential method for sperm selection to investigate the efficacy of this technique in improving ICSI outcomes. Materials and Methods: This cross-sectional study was performed on 95 couples. Sperm parameters and sperm DNA fragmentation (SDF) were measured. The couples were divided into the following 3 groups: group I (n=30) where SDF was between 15% and 30%, and routine sperm was selected on the basis of motility and morphology; group II (n=34) where SDF was more than 30%, and the routine sperm selection method was applied on the basis of motility and morphology; and group III (n=31) where SDF was more than 30%, and the sperm selection was performed on the basis of the zeta method. The fertilization rate, embryo development, embryo quality, and implantation rate were evaluated in these 3 groups. Results: The fertilization rate was significantly higher in group I compared with group II (P<0.05). The embryo development rate in group I was significantly higher than that in group II (P<0.001) and group III (P<0.05), and it was significantly lower in group II compared with group III (P<0.05). The embryo quality was higher in group III compared with group II (P<0.01). The implantation rate in group I was significantly higher than that in group II (P<0.05) and group III (P<0.05). Conclusion: The present study indicated that a higher level of SDF has an adverse effect on the ICSI outcome. Furthermore, the zeta potential technique can be a useful method for sperm selection in OAS men. [GMJ.2018;7:e1107]
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