bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological parameters and stromal desmoplastic status affecting accurate diagnosis of extraprostatic extension of prostate cancer using multi‐parametric magnetic resonance imaging
Authors: Okano Kousuke , Miyai Kosuke , Mikoshi Ayako , Edo Hiromi , Ito Keiichi , Tsuda Hitoshi , Shinmoto Hiroshi 
Published: January 2024

ObjectiveTo investigate the clinicopathological factors affecting discrepancies between multi‐parametric magnetic resonance imaging (mpMRI) and histopathological evaluation for diagnosis of extraprostatic extension (EPE) of prostate cancer.MethodsOne hundred‐and‐three lesions from 96 cases with suspected EPE on preoperative mpMRI, of which 60 and 43 showed bulging and frank capsular breach, respectively, were grouped according to pathological (p)EPE in radical prostatectomy specimens. Additionally, clinicopathological/immunohistochemical findings for periostin reflecting a desmoplastic stromal reaction were compared between these groups.ResultspEPE was detected in 49 (48%) of the 103 lesions. Of these, 25 (42%) showed bulging and 24 (56%) showed frank capsular breach on MRI. In the total cohort, the absence of pEPE was significantly associated with a lower Gleason Grade Group (GG) (p < 0.0001), anterior location (p = 0.003), absence of intraductal carcinoma of the prostate (IDC‐P) (p = 0.026), and high stromal periostin expression (p < 0.0001). These trends were preserved in subgroups defined by MRI findings, except for anterior location/IDC‐P in the bulging subgroup.ConclusionsGG, anterior location, and periostin expression may cause mpMRI–pathological discrepancies regarding EPE. Periostin expression was a significant pEPE‐negative factor in all subgroup analyses. Our results indicate that patients with suspected EPE on MRI, regardless of their pEPE results, should be followed as carefully as those with definite pEPE.
Novel image‐guided marker aimed at organ‐preserving therapies for prostate cancer
Authors: Okihara Koji , Ueda Takashi , Fujihara Atsuko , Shiraishi Takumi , Iwasaki Hiroshi , Nomoto Takeshi , Masui Koji , Ito‐Ihara Toshiko , Hara Eri , Nakai Ryusuke , Shiina Tsuyoshi , Ukimura Osamu 
Published: January 2024

ObjectiveWe developed fiducial imaging‐guidance markers for the prostate with less imaging artifacts than currently commercially available markers. The aim of this study was to evaluate the imaging artifacts and potential usefulness and safety of these novel fiducial imaging markers in preclinical experiments.MethodsWe selected specific metal materials and a shape that can minimize artifacts in line with a license we obtained for a metal with a gold‐platinum (Au‐Pt) alloy composition that maximized artifact‐free MRI images. Both phantom and canine prostate tests were conducted in order to evaluate the imaging artifacts for three imaging modalities, MRI, CT and ultrasound, and the risk of migration of the markers from the site of insertion to elsewhere, as well as crushing.ResultsThe newly developed Au‐Pt material had less imaging artifacts in the MRI, CT and ultrasound imaging modalities in comparison with current commercially available fiducial markers made from gold materials only. The Au‐Pt markers had sufficient strength and durability and were considered to be potentially clinically useful and safe markers.ConclusionThe developed Au‐Pt markers could be potential tools for accurate lesion‐targeted, organ‐preserving therapies such as lesion‐targeted focal therapy and active surveillance in addition to conventional radiation therapies.
Enhanced microwave absorption of refractory SiBCN metamaterials
Authors: Qiao Mengke , Li Xiangcheng , Chen Pingan , Zhu Yingli 
Published: January 2024

AbstractSo far, developed microwave absorbers exhibit significant changes in absorption with temperature, which hinder their operation within a wide temperature range. In this paper, a microwave absorber based on SiBCN ceramics was prepared. Due to the excellent high‐temperature stability of SiBCN ceramics, its permittivity changes less with temperature, avoiding the issue of performance deterioration or even failure that traditional refractory absorbers face at high temperatures. The experiment proves the absorption bandwidth for –15 dB of the SiBCN metamaterials absorber (SMA) is 12 GHz at 800°C, with a maximum absorptivity of 99.99%. According to the computed data, the resonance loss contributes 81.9 to 94.5% of the microwave absorption of SMA. This work demonstrates significant potential for applications in radar stealth under harsh conditions.
Approaching religious fatalism in cancer screening education
Authors: Brevik Thea Beate , Sæther Knut Willy 
Published: January 2024

AbstractRationaleReligious fatalism has for decades been pointed out as a barrier to cancer screening attendance and several studies suggest interventions to decrease fatalism, given its negative impact on the uptake of cancer screening.Aims and ObjectivesOur objective in this interdisciplinary exploration on religious fatalism in the context of cancer screening is to contribute to the increasing academic discussion on religious fatalism and cancer screening as well as the broader context of the intersection of religion and bioethics.MethodThrough an analysis of religious fatalism in light of the notion of rationality and images of God, we find resources and suggest trajectories for a more seriously and constructively approach to religious fatalism in cancer education.Results and ConclusionOur main thesis is that interventions do not necessarily have to decrease religious fatalism to increase screening.
Natural product honokiol exhibits antiviral effects against Micropterus salmoides rhabdovirus (MSRV) both in vitro and in vivo
Authors: Yang Fei , Yang Bin , Song Kaige , Jin Yingjie , Wang Gaoxue , Li Pengfei , Yu Qing , Ling Fei 
Published: January 2024

AbstractMicropterus salmoides rhabdovirus (MSRV) is a formidable pathogen, presenting a grave menace to juvenile largemouth bass. This viral infection frequently leads to epidemic outbreaks, resulting in substantial economic losses within the aquaculture industry. Unfortunately, at present, there are no commercially available vaccines or pharmaceutical treatments to combat this threat. In order to address the urgent need for therapeutic strategy to resist MSRV infection, the antiviral activity of natural product honokiol against MSRV was explored in this study. Firstly, cellular morphology was directly observed in an inverted microscope when treated with honokiol after MSRV infection. The results clarified that honokiol significantly lessened cytopathic effect (CPE) induced by MSRV and protected the integrity of GCO cells. Furthermore, the viral nucleic acid expression (G gene) was detected by reverse transcription real‐time quantitative PCR (RT‐qPCR) and the results indicated that honokiol significantly decreased the viral loads of MSRV in a concentration‐dependent manner, and honokiol showed a high antiviral activity with IC50 of 2.92 μM. Besides, honokiol significantly decreased the viral titre and suppressed apoptosis caused by MSRV. Mechanistically, honokiol primarily inhibited the initial replication of MSRV and discharge of progeny virus to exert anti‐MSRV activity. More importantly, in vivo experiments suggested that honokiol (40 mg/kg) expressed a fine antiviral activity against MSRV when administrated with intraperitoneal injection, which led to a notable 40% improvement in the survival rate among infected largemouth bass. In addition, it also resulted in significant reduction in the viral nucleic acid expression within liver, spleen and kidney at 2, 4 and 6 days following infection. What is more, 100 mg/kg honokiol with oral administration also showed certain antiviral efficacy in MSRV‐infected largemouth bass via improving the survival rate by 10.0%, and decreasing significantly the viral nucleic acid expression in liver, spleen and kidney of largemouth bass on day 2. In summary, natural product honokiol is a good candidate to resist MSRV infection and has promising application prospects in aquaculture.
Filament coating system assists recovery of ablative fCO2 laser treatment: A split‐face clinical observation
Authors: Sun Yan , Chen ShuYan , Zhang Ying , Qi Xin , Guo DeChao , Feng Bo , Qi RuiQun , Wu Yan , Gao XingHua 
Published: January 2024

AbstractBackgroundThe current nursing procedure after fractional carbon dioxide (fCO2) is complex and needs to be optimized. The present study was conducted to evaluate the assisting effect of filament coating system after fCO2 laser treatment.MethodsChinese individuals aged from 18 to 65 years diagnosed as photoaging or atrophic acne scar were recruited and each participant was treated with one single pass of fCO2 laser. A split face was randomly assigned as treatment side or control side. For control side, conventional procedure was topically applied respectively, including desonide cream two times for 3 days, fusidic acid cream two times for 7 days, and recombinant human epidermal growth factor (RhEGF) gel four times for 7 days; for treating side, a filament coating system was applied immediately after one application of fusidic acid cream, desonide cream and RhEGF, and removed 3 h later, for 3 days. Erythema, edema, crust, and pain on both sides were scored from 0 to 10 before and 1, 2, 4, and 7 days after fCO2 laser treatment. Stratum corneum hydration (SCH) and sebum of forehead and cheek on both sides were also measured by using Corneometer‐Sebumeter.ResultsTwenty photoaging and 11 atrophic acne scar participants finished the observation. All of them complained of erythema, edema, crust, and pain after fCO2 laser treatment, and the scores decreased as time passed by. There were no statistical significances of erythema, edema, crust, pain, SCH, and sebum between treating side and control side at each observation time.ConclusionFilament coating system was effective, safe, convenient, and economic in assisting recovery of ablative fCO2 laser, which might be a new option for additional nursing procedure.
Breath characteristics and adventitious lung sounds in healthy and asthmatic horses
Authors: Greim Eloïse , Naef Jan , Mainguy‐Seers Sophie , Lavoie Jean‐Pierre , Sage Sophie , Dolf Gaudenz , Gerber Vinzenz 
Published: January 2024

AbstractBackgroundStandard thoracic auscultation suffers from limitations, and no systematic analysis of breath sounds in asthmatic horses exists.ObjectivesFirst, characterize breath sounds in horses recorded using a novel digital auscultation device (DAD). Second, use DAD to compare breath variables and occurrence of adventitious sounds in healthy and asthmatic horses.AnimalsTwelve healthy control horses (ctl), 12 horses with mild to moderate asthma (mEA), 10 horses with severe asthma (sEA) (5 in remission [sEA−], and 5 in exacerbation [sEA+]).MethodsProspective multicenter case‐control study. Horses were categorized based on the horse owner‐assessed respiratory signs index. Each horse was digitally auscultated in 11 locations simultaneously for 1 hour. One‐hundred breaths per recording were randomly selected, blindly categorized, and statistically analyzed.ResultsDigital auscultation allowed breath sound characterization and scoring in horses. Wheezes, crackles, rattles, and breath intensity were significantly more frequent, higher (P < .001, P < .01, P = .01, P < .01, respectively) in sEA+ (68.6%, 66.1%, 17.7%, 97.9%, respectively), but not in sEA− (0%, 0.7%, 1.3%, 5.6%) or mEA (0%, 1.0%, 2.4%, 1.7%) horses, compared to ctl (0%, 0.6%, 1.8%, −9.4%, respectively). Regression analysis suggested breath duration and intensity as explanatory variables for groups, wheezes for tracheal mucus score, and breath intensity and wheezes for the 23‐point weighted clinical score (WCS23).Conclusions and Clinical Importance.The DAD permitted characterization and quantification of breath variables, which demonstrated increased adventitious sounds in sEA+. Analysis of a larger sample is needed to determine differences among ctl, mEA, and sEA− horses.
Foraminoplasty Performed with a Trephine and a New Tool in Transforaminal Endoscopic Lumbar Discectomy: A Single‐Center Retrospective Study
Authors: Zhu Guangye , He Jiahui , Song Zefeng , Chen Honglin , Ge Zhilin , Zhang Peng , Ren Hui , Li Yuwei , Tang Jingjing , Jiang Xiaobing 
Published: January 2024

ObjectiveForaminoplasty is an important step in transforaminal endoscopic lumbar discectomy (TELD). A trephine is widely used in foraminoplasty. However, foraminoplasty using a trephine alone sometimes fails to remove the resected bone, resulting in the bone remaining in the foramen or spinal canal, which can potentially cause neurological irritation or injury. The objective of this study is to introduce a self‐designed tool, referred to as an anchoring drill, for use with a trephine in foraminoplasty in TELD and to evaluate its advantages.MethodsA retrospective review was performed to identify patients who underwent L4–5 TELD between January 2019 to January 2022. Foraminoplasty was performed in all patients. Depending on whether the anchoring drill was used or not, patients were divided into two groups. Surgery‐related parameters and complications were reviewed. Visual analog scale (VAS) and Japanese Orthopaedic Association (JOA) scores were also assessed for all patients. SPSS statistical software was used for statistical calculation.ResultsA total of 100 patients were included (55 in the anchoring drill group and 45 in the trephine group). The incidence of residual bone fragments after foraminoplasty of the anchoring drill group was 9.09%, which was lower than that of the trephine group, at 33.33% (p < 0.05). The mean endoscopic operation time of the anchoring drill group was shorter than that of the trephine group (p < 0.05). The mean fluoroscopy time and duration of foraminoplasty showed no significant differences between the two cohorts. The total perioperative complication incidence was lower in the anchoring drill group, in which the neural irritation incidence showed a significant difference (anchoring drill group: 3.64%, trephine group: 17.78%, p < 0.05). VAS and JOA scores were significantly improved after the operation for all patients (p < 0.001), however, no statistical differences were found between the two groups at each follow‐up visit.ConclusionThe combination of a trephine with an anchor drill was demonstrated to be safe and effective in foraminoplasty in TELD, improving the success rate of foraminoplasty and reducing neurological complications compared to using trephine alone.
Understanding the relations between Solanaceae crops and their pollinators: a global meta‐network
Authors: de Souza G. T. , Torquato I. H. S. , Castro C. C. 
Published: January 2024

AbstractCrop–pollinator interactions are essential for world food security. Studying crop pollination from a network approach allows identification of target pollinators for conservation and management, and gaps in our knowledge. Solanaceae represents the third highest ranked family based on economic value, and its production is highly improved by animal pollination. This study aimed to integrate global data on solanaceous crop pollination and analyse the interaction patterns using a meta‐network approach. Our questions were: (i) how are interactions structured and what are the structuring roles of species; and (ii) what are the main gaps in our knowledge?Data were obtained through a systematic review of the main scientific databases. The network structure was described using connectivity and modularity calculations, and the role of species using centrality metrics.The 251 pollinator species reported were in seven orders, mainly Hymenoptera (84.9%). The generalistsBombusandApisspecies were the most common pollinators. The meta‐network was modular, and all modules mostly included bees. Most species were peripherals, around 12% were connectors, and there were no module hubs.Apis melliferawas the only network hub (supergeneralist).The most important pollinators are the most managed pollinators worldwide; however, many native species play a role in structuring the meta‐network. Main gaps include species of importance to pepper pollination, lack of species‐specific identification, and the need for more robust experimental studies evaluating the pollination efficiency of native, manageable bees.
Strong plastic responses in aerenchyma formation in F1 hybrids of Imperata cylindrica under different soil moisture conditions
Authors: Nomura Y. , Arima S. , Kyogoku D. , Yamauchi T. , Tominaga T. 
Published: January 2024

Abstract
Hybrids can express traits plastically, enabling them to occupy environments that differ from parental environments. However, there is insufficient evidence demonstrating how phenotypic plasticity in specific traits mediates hybrid performance. Two parental ecotypes of Imperata cylindrica produce F1 hybrids. The E‐type in wet habitats has larger internal aerenchyma than the C‐type in dry habitats. This study evaluated relationships between habitat utilisation, aerenchyma plasticity, and growth of I. cylindrica accessions. We hypothesize that plasticity in expressing parental traits explains hybrid establishment in habitats with various soil moisture conditions.
Aerenchyma formation was examined in the leaf midribs, rhizomes and roots of two parental ecotypes and their F1 hybrids in their natural habitats. In common garden experiments, we examined plastic aerenchyma formation in leaf midribs, rhizomes and roots of natural and artificial F1 hybrids and parental ecotypes and quantified vegetative growth performance.
In the natural habitats where soil moisture content varied widely, the F1 hybrids showed larger variation in aerenchyma formation in rhizomes than their parental ecotypes. In the common garden experiments, F1 hybrids showed high plasticity of aerenchyma formation in rhizomes, and their growth was similar to that of C‐type and E‐type under drained and flooded conditions, respectively.
The results demonstrate that F1 hybrids of I. cylindrica exhibit plasticity in aerenchyma development in response to varying local soil moisture content. This characteristic allows the hybrids to thrive in diverse soil moisture conditions.
Analysis of histone H3K4me3 modifications in bovine placenta derived from different calf‐production methods
Authors: Hattori Kanoko , Hoshino Yoichiro , Kachi Masayuki , Masuda Yasumitsu , Yamamoto Satoshi , Honda Shinnosuke , Minami Naojiro , Ikeda Shuntaro 
Published: January 2024

AbstractIn ruminants, the overgrowth of offspring produced by in vitro fertilization (IVF) is a common problem. Abnormal epigenetic modifications caused by environmental factors during the early embryonic period are suspected as an aetiology of overgrowth. In this study, we investigated the genome‐wide histone H3K4me3 profiles of bovine placentae that play a pivotal role in foetal development and compared their characteristics between artificial insemination (AI)‐ and IVF‐derived samples. Cotyledons were harvested from the placentae obtained at parturition of 5 AI‐ and 13 IVF‐derived calves, and chromatin immunoprecipitation sequencing was performed for H3K4me3. We confirmed no significant maternal tissue contamination in the samples we used. The revealed H3K4me3 profiles reflected the general characteristics of the H3K4me3 modification, which is abundantly distributed in the promoter region of active genes. By extracting common modifications from multiple samples, the genes involved in placenta‐specific biological processes could be enriched. Comparison with the H3K4me3 modifications of blastocyst samples was also effective for enriching the placenta‐specific features. Principal component analysis suggested the presence of differential H3K4me3 modifications in AI‐ and IVF‐derived samples. The genes contributing to the difference were related to the developmental biological processes. Imprinted genes such as BEGAIN, ZNF215 and DLX5 were among the extracted genes. Principal component and discriminant analyses using only male samples categorized the samples into three groups based on foetal weight and calf‐production methods. To our knowledge, this is the first study to profile the genome‐wide histone modifications of bovine foetal placentae and reveal their differential characteristics between different calf‐production methods.
Tax policy competition under destination‐based taxation
Authors: Beyer Thomas , Gresik Thomas A. 
Published: January 2024

AbstractWe extend Bond and Gresik (On the incentive compatibility of universal adoption of destination‐based cash flow taxation, International Tax and Public Finance, October 2022) by analyzing the equilibrium capital expense deduction policies that arise when countries compete for multinational investment under destination‐based taxation. Bond and Gresik proved that destination‐base cash flow taxation cannot arise as a tax competition equilibrium. We show that policies that allow for no deduction (income taxation) and those that allow a partial deduction can arise in equilibrium. In the former case, public good provision will be efficient. In the latter case, weak over‐provision of the public good will arise.
Longitudinal association between oral function and underweight onset among community‐dwelling older adults: Role of regular self‐weighing
Authors: Kubo Yuta , Fujii Keisuke , Noguchi Taiji , Hayashi Takahiro , Tomiyama Naoki , Ochi Akira , Hayashi Hiroyuki 
Published: January 2024

AbstractAimsRegular self‐weighing is effective in weight management and may help to mitigate the risk of underweight among older adults. We examined which factors of oral function are associated with a risk for underweight among community‐dwelling older adults and whether regular self‐weighing can mitigate that risk.MethodsThis was a cohort study. Self‐administered questionnaires were mailed to 7665 older adults in March 2019 (response rate 74.3%) and 7591 in March 2020 (response rate 74.7%). Among those who responded to both surveys, 3594 older adults who were not underweight in March 2019 were included (follow‐up rate: 59.2%). We examined the association between dysphagia, poor masticatory function, and dry mouth and the development of underweight, and whether regular self‐weighing reduced the risk for underweight.ResultsThe average age ± standard deviation of participants was 71.1 ± 3.4 years. There was a significant association between swallowing difficulty and the occurrence of underweight (odds ratio = 1.65, p = .012). However, this relationship did not differ significantly with regular self‐weighing (p = .477).ConclusionsThese study findings suggest that to prevent underweight among community‐dwelling older adults, it is important to focus on those with poor swallowing function.