bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison Between the Photodynamic Action of “Hypocrellin A” and “Pheophorbide a” against Bacteria and SARS-CoV-2 Virus --- A Mini-Review
Authors: Law Siu Kan 
Published: February 2024

:
Hypocrellin A and Pheophorbide a are well-known organic chemicals that may be contained in herbal products. They can act as photosensitizers and have a strong photodynamic effect on
bacteria. In any case, are these photosensitizers appropriate for photodynamic treatment against the
SARS-CoV-2 infection? The principles of photodynamic therapy are the same regardless of the target. It causes selective cytotoxicity at the site of infection through activation of photosensitizer under
light irradiation to generate cytotoxic reactive oxygen species (ROS), leading to the death of infected
cells. Is antimicrobial photodynamic therapy a good choice against the SARS-CoV-2 virus?

Methods:
Nine electronic databases were searched, including WanFang Data, PubMed, Science
Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), regardless of term, and language restrictions. All eligible studies were analyzed
and summarized in this review.

Results:
“Hypocrellin A” and “Pheophorbide a” were effective for bacterial and SARS-CoV-2 in
photodynamic therapy. 99.98 % of S. aureus was killed when incubated with the 10-3 M Hypocrellin
A and illuminated a 490 nm in 30 mW/cm2 for 120 min. The difference was Pheophorbide a could
also inhibit gram-negative bacteria, such as P. aeruginosa with a concentration of 1 µg/ml for 2 hr
irradiated of a 671 nm laser in 0.3 W of 1 J, and a nearly 100 % suppression rate. “Hypocrellin A”
and “Pheophorbide a” with antiviral activity, and virucidal effects for preventing and treating the
infection.

Conclusion:
Based on previous studies, “Hypocrellin A” and “Pheophorbide a” are photosensitizers
used for photodynamic therapy against bacteria or SARS-CoV-2, however, much more works need
to be done in the future including the development of a better way for systematic infectious disease,
and its correlated infections for the application of photodynamic therapy.
Arabic Web-Based Information on Oral Lichen Planus: Content Analysis
Authors: AlMeshrafi Azzam , AlHamad Arwa F , AlKuraidees Hamoud , AlNasser Lubna A 
Published: February 2024

Background
The use of web-based health information (WBHI) is on the rise, serving as a valuable tool for educating the public about health concerns and enhancing treatment adherence. Consequently, evaluating the availability and quality of context-specific WBHI is crucial to tackle disparities in health literacy and advance population health outcomes.

Objective
This study aims to explore and assess the quality of the WBHI available and accessible to the public on oral lichen planus (OLP) in Arabic.

Methods
The Arabic translation of the term OLP and its derivatives were searched in three general search platforms, and each platform’s first few hundred results were reviewed for inclusion. We excluded content related to cutaneous LP, content not readily accessible to the public (eg, requiring subscription fees or directed to health care providers), and content not created by health care providers or organizations (ie, community forums, blogs, and social media). We assessed the quality of the Arabic WBHI with three standardized and validated tools: DISCERN, Journal of the American Medical Association (JAMA) benchmarks, and Health On the Net (HON).

Results
Of the 911 resources of WBHI reviewed for eligibility, 49 were included in this study. Most WBHI resources were provided by commercial affiliations (n=28, 57.1%), with the remainder from academic or not-for-profit affiliations. WBHI were often presented with visual aids (ie, images; n=33, 67.4%). DISCERN scores were highest for WBHI resources that explicitly stated their aim, while the lowest scores were for providing the effect of OLP (or OLP treatment) on the quality of life. One-quarter of the resources (n=11, 22.4%) met all 4 JAMA benchmarks, indicating the high quality of the WBHI, while the remainder of the WBHI failed to meet one or more of the JAMA benchmarks. HON scores showed that one-third of WBHI sources had scores above 75%, indicating higher reliability and credibility of the WBHI source, while one-fifth of the sources scored below 50%. Only 1 in 7 WBHI resources scored simultaneously high on all three quality instruments. Generally, WBHI from academic affiliations had higher quality scores than content provided by commercial affiliations.

Conclusions
There are considerable variations in the quality of WBHI on OLP in Arabic. Most WBHI resources were deemed to be of moderate quality at best. Providers of WBHI could benefit from increasing collaboration between commercial and academic institutions in creating WBHI and integrating guidance from international quality assessment tools to improve the quality and, hopefully, the utility of these valuable WBHI resources.
Nudges and Prompts Increase Engagement in Self-Guided Digital Health Treatment for Depression and Anxiety: Results From a 3-Arm Randomized Controlled Trial
Authors: van Mierlo Trevor , Rondina Renante , Fournier Rachel 
Published: February 2024

Background
Accessible and effective approaches to mental health treatment are important because of common barriers such as cost, stigma, and provider shortage. The effectiveness of self-guided treatment is well established, and its use has intensified because of the COVID-19 pandemic. Engagement remains important as dose-response relationships have been observed. Platforms such as Facebook (Meta Platform, Inc), LinkedIn (Microsoft Corp), and X Corp (formerly known as Twitter, Inc) use principles of behavioral economics to increase engagement. We hypothesized that similar concepts would increase engagement in self-guided digital health.

Objective
This 3-arm randomized controlled trial aimed to test whether members of 2 digital self-health courses for anxiety and depression would engage with behavioral nudges and prompts. Our primary hypothesis was that members would click on 2 features: tips and a to-do checklist. Our secondary hypothesis was that members would prefer to engage with directive tips in arm 2 versus social proof and present bias tips in arm 3. Our tertiary hypothesis was that rotating tips and a to-do checklist would increase completion rates. The results of this study will form a baseline for future artificial intelligence–directed research.

Methods
Overall, 13,224 new members registered between November 2021 and May 2022 for Evolution Health’s self-guided treatment courses for anxiety and depression. The control arm featured a member home page without nudges or prompts. Arm 2 featured a home page with a tip-of-the-day section. Arm 3 featured a home page with a tip-of-the-day section and a to-do checklist. The research protocol for this study was published in JMIR Research Protocols on August 15, 2022.

Results
Arm 3 had significantly younger members (F2,4564=40.97; P<.001) and significantly more female members (χ24=92.2; P<.001) than the other 2 arms. Control arm members (1788/13,224, 13.52%) completed an average of 1.5 course components. Arm 2 members (865/13,224, 6.54%) clicked on 5% of tips and completed an average of 1.8 course components. Arm 3 members (1914/13,224, 14.47%) clicked on 5% of tips, completed 2.7 of 8 to-do checklist items, and completed an average of 2.11 course components. Completion rates in arm 2 were greater than those in arm 1 (z score=3.37; P<.001), and completion rates in arm 3 were greater than those in arm 1 (z score=12.23; P<.001). Engagement in all 8 components in arm 3 was higher than that in arm 2 (z score=1.31; P<.001).

Conclusions
Members engaged with behavioral nudges and prompts. The results of this study may be important because efficacy is related to increased engagement. Due to its novel approach, the outcomes of this study should be interpreted with caution and used as a guideline for future research in this nascent field.

International Registered Report Identifier (IRRID)
RR2-10.2196/37231
Dialysate Sodium Lowering in Maintenance Hemodialysis
Authors: Miskulin Dana C. , Tighiouart Hocine , Hsu Caroline M. , Weiner Daniel E. 
Published: February 2024

Key Points

Treatment to dialysate sodium 135 versus 138 mEq/L led to no difference in the rate of change in intradialytic hypotension, but symptoms were greater in the low arm.Use of a dialysate sodium concentration of 135 versus 138 mEq/L led to a small reduction in interdialytic weight gain, but had no effect on predialysis BP.Raising dialysate sodium concentration from 135 to 140 mEq/L reduced intradialytic hypotension and was associated with a marked increase in BP.

Background
Lowering dialysate sodium concentration may improve volume and BP control in patients on maintenance hemodialysis.

Methods
We randomized 42 participants 2:1 to dialysate sodium 135 versus 138 mEq/L for 6 months. This was followed by a 12-week extension phase in which sodium was increased to 140 mEq/L in low-arm participants. The primary outcome was intradialytic hypotension (IDH). Secondary outcomes included dialysis disequilibrium symptoms, emergency room visits/hospitalizations, interdialytic weight gain, and BP. Longitudinal changes across arms were analyzed using linear mixed regression.

Results
Treatment to dialysate sodium 135 versus 138 mEq/L was not associated with a difference in a change in the rate of IDH (mean change [95% confidence interval], 2.8 [0.8 to 9.5] versus 2.7 [1.1 to 6.2] events per 100 treatments per month); ratio of slopes 0.96 (0.26 to 3.61) or emergency room visits/hospitalizations (7.3 [2.3 to 12.4] versus 6.7 [2.9 to 10.6] events per 100 patient-months); difference 0.6 (−6.9 to 5.8). Symptom score was unchanged in the 135 mEq/L arm (0.7 [−1.4 to 2.7]) and decreased in the 138 mEq/L arm ([5.0 to 8.5 to 2.0]; difference 6.0 [2.1 to 9.8]). Interdialytic weight gain declined in the 135 mEq/L arm and was unchanged in the 138 mEq/L arm (−0.3 [−0.5 to 0.0] versus 0.3 [0.0 to 0.6] kg over 6 months; difference [−0.6 (−0.1 to −1.0)] kg). In the extension phase, raising dialysate sodium concentration from 135 to 140 mEq/L was associated with an increase in interdialytic weight gain (0.2 [0.1 to 0.3] kg) and predialysis BP (7.0 [4.8 to 9.2]/3.9 [2.6 to 5.1] mm Hg) and a reduction in IDH (odds ratio, 0.66 [0.45 to 0.97]).

Conclusions
Use of a dialysate sodium concentration of 135 as compared with 138 mEq/L was associated with a small reduction in interdialytic weight gain without affecting IDH or predialysis BP, but with an increase in symptoms. Raising dialysate sodium concentration from 135 to 140 mEq/L was associated with a reduction in IDH, small increase in interdialytic weight gain, and marked increase in predialysis BP.

Clinical Trial registration number

NCT03144817.
Impact of information usefulness and adoption in social media on purchase intention :Evidence of Indonesia
Authors: Subekti Toni Ahmad , Nugroho Sahid Susilo 
Published: February 2024

The Product reviews on YouTube Channel offer information for consumers to evaluate products before making a decision. Understanding how consumers adopt the information and its impact on purchase intention becomes crucial. This study aims to determine the influence of information usefulness and information adoption on purchase intention on YouTube channels. The study developed a research model based on the Information Adoption Model (IAM) and Theory of Reasoned Action (TRA). A survey design was employed to test the proposed linkages among variables with a sample size of 447 respondents by the purposive sampling method. The study deploys the partial least squares path modeling (PLS-SEM) to analyze the data. The results confirmed that relevance, comprehensiveness, source expertise, attitude toward information, and information usefulness positively affect information adoption and purchase intention. Additionally, attitude toward information has a positive influence on behavioral intentions. However, timeliness, accuracy, and source expertise do not have any significant relationship with the information usefulness
Response of Growth and Seed Yield of Mung Bean (Vigna radiata L.) to Chicken Manure and Banana Hump Liquid Organic Fertilizer Application
Authors: Kurniasari Leli , Anggriawan Feri , Lestari Sri Ayu Dwi , Sulistyo Nanti Bambang Eko , Syahban Rahmat Ali , Rahayu Sri 
Published: February 2024

Mung bean is highly important legume crop in Indonesia. Attempts to improve the yield and quality of mung bean seeds can be done through improving the planting media by adding organic fertilizer. The objective of this study was to determine the response of growth and seeds production of mung bean due to chicken manure and banana hump organic fertilizer. The research was performed in the greenhouse at the Balai Pengujian Standar Instrumen Tanaman Aneka Kacang (BSIPTAKA), Muneng Probolinggo. This study was structured in a factorial block design with three replications executed randomly. The first factor was doses of CM consisting of 0, 8.3, 16.7, and 25 ton/ha. The second factor was concentrations of banana hump liquid organic fertilizer (LOF) consisting of 0, 10, 20, and 30 ml/L. The result showed that doses of CM had a significant effect on plant height at 10 DAP, seed weight per plant, and seed yield. The interaction between CM doses and banana hump LOF was able to increase leaf chlorophyll index at 30 DAP. Combination of 16.7 ton/ha CM and 20 ml/L banana hump LOF produced the highest average chlorophyll index of 55.07 CCI. Keywords: Chlorophyll index, Manure, Mung bean, Organic fertilizer, Seed.
Effect of Drought Periods on Rice Lines Growth and Yield
Authors: Margaret Swisci , Nafisah Nafisah , Sujinah Sujinah , Rumanti Indrastuti Apri , Yunani Nani 
Published: February 2024

Numerous variables, such as drought period, growth stage, and varieties, influence rice growth and yield in response to drought. This study was conducted to determine the effect of drought periods on the growth and yields of several rice lines and varieties as well as to select drought-tolerant lines. Using a split-plot design with three replications, the pot experiment was carried out in the greenhouse from December 2015 to April 2016 at the Sukamandi Experimental Site of Indonesian Center for Rice Research (BB Padi). Drought periods were treated as the main-plot, while the rice lines/varieties were treated as sub-plots. The main-plot consists of four levels: control, drought at the maximum tillering stage, drought at the primordia stage, and drought at the grain filling stage. The rice lines used are expand lines of rainfed lowland rice and upland rice from the BB Padi breeding program. The results showed that of the 36 rice lines and 6 varieties tested, drought periods during maximum tillering and primordia affected plant height, while the tiller number was not affected by all drought periods. From the yield characters, drought periods increased unfilled grain percentage and decreased 1000 grains weight and also grain weight per plant. Jatiluhur is consistently tolerant and has the highest yield. There are 8 rice lines with consistent tolerance and not significantly different yields with Jatiluhur: B13650E-TB-80-2, B14168E-MR-6, B14168E-MR-10, B14168E-MR-11, B14168E-MR-12, B14168E-MR-13, B12480D-MR-7-1-1, and B12056F-TB-1-29-1. Keywords: Drought periods, Rice lines, Growth, Yield
Desain e-Modul Fisika Sebagai Pembelajaran Berbasis Masalah dalam Meningkatkan Hasil Belajar Siswa
Authors: Andriani Welli , Sundari Putri Dwi , Dwiridal Letmi , Dewi Wahyuni Satria , Fortuna Aprilla 
Published: February 2024

Pembelajaran fisika adalah pembelajaran yang tidak terlepas dari pembelajaran matematis, sehingga siswa cenderung lebih mudah bosan jika bahan ajar dan model pembelajaran yang digunakan tidak sesuai, sehingga menyebabkan rendahnya motivasi siswa untuk belajar dan mengakibatkan rendahnya hasil belajar siswa. Dalam menyelesaikan permasalahan ini, perlu adanya perkembangan teknologi, perangkat pembelajaran semakin mengacu pada digitalisasi seperti bahan ajar yang digunakan sudah mulai berbasis digital sehingga lebih interaktif seperti penggunaan e-modul, yang dapat memuat gambar, animasi, audio dan vidio pembelajaran, agar siswa lebih tertarik untuk belajar, selain bahan ajar model pembelajaran juga menunjang tercapainya tujuan pembelajaran, model pembelajaran yang dapat digunakan supaya siswa aktif dalam proses belajar yaitu pembelajaran berbasis masalah. Penelitian ini bertujuan untuk menghasilkan desain e-modul fisika sebagai pembelajaran berbasis masalah guna meningjatkan hasil belajar siswa. Penelitian ini termaksuk penelitian pengembangan. Model pengembanagn yang digunakan adalah prototipe model yaitu tahap pertama listen to customer, tahap kedua yaitu build/revise mock-up(perancangan dan tahap selanjutnya yaitu customer test driver mock-up (evaluasi). E-modul ini didesain dengan aplikasi canva untuk mendesain cover dan tampilan modul dan bantuan hyzine flipbook untuk membuat tampilan modul lebih interaktif.
Analisis Penerapan Technological Pedagogical And Content Knowledge (TPACK) Dalam Pembelajaran Sejarah Kebudayaan Islam di kelas X Madrasah Aliyah
Authors: Padila Cisia , Nelwati Sasmi , Misra Misra , Safni Pela 
Published: February 2024

Penelitian ini bertujuan untuk menganalisis penerapan Technological Pedagogical And Content Knowledge (TPACK) dalam konteks pembelajaran Sejarah Kebudayaan Islam di kelas X Madrasah Aliyah. Dengan mempertimbangkan kompleksitas materi sejarah kebudayaan islam dan kebutuhan integrasi teknologi dalam pembelajaran modern, penelitian ini menjelaskan bagaimana guru dapat mengoptimalkan pengetahuan teknologi, pedagogi, dan konten untuk meningkatkan efektivitas pembelajaran. Metode penelitian yang digunakan mencakup observasi, wawancara dengan guru, dan dokumentsai. Hasil penelitian menunjukkan bahwa guru di kelas X Madrasah Aliyah telah mencoba menerapkan TPACK, tetapi masih ditemui beberapa kendala, terutama terkait dengan kurangnya waktu pembelajaran sehingga beberapa materi kurang mendalam disampaikan dan kesulitan guru dalam penilaian karena ada beberapa aspek baru yang dipakai dalam kurikulum merdeka ini yang sedikit banyaknya berbeda dengan K13. Analisis TPACK pada tingkat guru membuktikan bahwa pengetahuan pedagogis dan konten sudah cukup baik, namun ada ruang untuk peningkatan dalam mengintegrasikan teknologi secara lebih efektif. Ditemukan bahwa guru yang dapat mengelola teknologi dengan baik mampu menciptakan lingkungan pembelajaran yang lebih dinamis dan menarik bagi siswa. Kesimpulan dari penelitian ini menekankan pentingnya pelatihan dan pengembangan profesional guru dalam hal TPACK. Rekomendasi termasuk penyediaan sumber daya dan dukungan yang memadai untuk membantu guru mengatasi hambatan yang mungkin muncul dalam mengadopsi pendekatan ini. Secara keseluruhan, penelitian ini memberikan wawasan mendalam tentang tantangan dan potensi penerapan
Internalisasi Konsep Tri Rahayu sebagai Upaya Pencegahan Bullying di Sekolah
Authors: Nur Kholiq Yusuf , Maesyaroh Wulan , Insani Nur Hanifah 
Published: February 2024

Bullying merupakan masalah serius yang harus segera dicegah. Salah satu upaya untuk mencegah bullying adalah dengan menginternalisasikan konsep Tri Rahayu. Penelitian ini bertujuan untuk 1) mendeskripsikan konsep Tri Rahayu sebagai upaya pencegahan bullying, 2) menganalisis relevansi konsep Tri Rahayu sebagai upaya pencegahan bullying di sekolah. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi Pustaka. Teknik pengumpulan data dilakukan menggunakan teknik dokumentasi. Data penelitian ini berupa informasi mengenai pencegahan bullying dan konsep Tri Rahayu. Sumber studi literatur dalam penelitian ini adalah artikel jurnal yang diakses melalui google scholar. Teknik analisis data pada penelitian ini menggunakan teknik analisis konten sedangkan teknik kebasahan data menggunakan triangulasi teori. Hasil penelitian menunjukan bahwa terdapat beberapa sikap yang dapat diinternalisasikan dalam konsep Tri Rahayu sebagai upaya pencegahan bullying. Sikap tersebut adalah mawas diri, tepa slira, aja dumeh, srawung, tulung tinulung, watak eling, waspada, lan tumindak alus sarwi aris, dan taat hukum. Konsep Tri Rahayu ini sangat relevan dengan upaya pencegahan bullying di sekolah karena konsep ini mengajarkan kebaikan dan kedamaian pada diri sendiri, sesame manusia, dan bangsa. Hasil penelitian ini memberikan konsep baru terkait upaya pencegahan bullying melalui konsep filosofis Ki Hadjar Dewantara yang dapat digunakan sebagai referensi dan pedoman pencegahan bullying di sekolah
Pelaksanaan Kurikulum Merdeka dalam Pembelajaran Bahasa Jawa di SMP Kabupaten Pemalang
Authors: Nurfita Dwi , Sukoyo Joko 
Published: February 2024

Perubahan kurikulum menyebabkan perlunya penyesuaian pembelajaran di sekolah, termasuk pada pembelajaran bahasa Jawa. Penerapan pembelajaran bahasa Jawa yang merupakan mata pelajaran muatan lokal sudah diterapkan pada tingkat SMP di Kabupaten Pemalang. Dalam pelaksanaannya perlu adanya pengawasan dari berbagai pihak terkait. Oleh karena itu penelitian ini bertujuan untuk mendeskripsikan pelaksanaan kurikulum merdeka dalam pembelajaran bahasa Jawa di Kabupaten Pemalang dan kesulitan dalam melaksanakan kurikulum merdeka. Metode yang digunakan yaitu deskriptif kualitatif dengan pengumpulan data observasi dan wawancara dengan guru bahasa Jawa di Kabupaten Pemalang. Hasil penelitian yang didapatkan yaitu pelaksanaan kurikulum merdeka pada pembelajaran bahasa Jawa SMP di Kabupaten Pemalang sudah berjalan pada kelas 7. Penyesuaian yang terjadi yaitu pada perubahan perangkat pembelajaran, pelaksanaan pembelajaran yang berpusat pada siswa, penilaian pembelajaran yang dilakukan berupa penilaian diagnostik, formatif dan sumatif serta kegiatan proyek (P5). Kesulitan yang dialami guru, seperti pemahaman guru mengenai konsep kurikulum merdeka yang berpengaruh pada kemampuan guru dalam menyusun perangkat pembelajaran, kurangnya referensi atau acuan dalam penyusunan modul ajar, pemilihan dan penggunaan media dan metode pembelajaran, serta pemahaman guru mengenai konsep penilaian kurikulum merdeka.