bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight gained via ultra‐performance liquid chromatography tandem mass spectrometry‐based metabolomics: Protective effect of Artemisia argyi H.Lév. & Vaniot essential oil on lipopolysaccharide‐induced liver injury mice
Authors: Zhou Hui , Rong Ying , Liu Fanglin , Yu Tong , Cui Weiqi , Cao Qianwen , Liu Luyao , Qin Zhaolong , Ma Xiaoge , Zhang Nan , Tang Youcai , Xu Xia 
Published: January 2024

AbstractArtemisia argyi H.Lév. & Vaniot essential oil (AAEO) has shown pharmacological effects such as anti‐inflammation, antioxidant, and anti‐tumor properties. However, the protective effect of AAEO on lipopolysaccharide (LPS)‐induced liver injury and its potential protective mechanism are still unclear. In this study, we used ultra‐performance liquid chromatography tandem mass spectrometry metabolomics techniques to investigate the changes in liver tissue metabolites in mice exposed to LPS with or without AAEO treatment for 14 days. The biochemical results showed that compared with the control group, AAEO significantly reduced the levels of liver functional enzymes, suggesting a significant improvement in liver injury. In addition, the 18 differential metabolites identified by metabolomics were mainly involved in the reprogramming of arachidonic acid metabolism, tryptophan metabolism, and purine metabolism. AAEO could significantly inhibit the expression of COX‐2, IDO1, and NF‐κB; enhance the body's anti‐inflammatory ability; and alleviate liver injury. In summary, our study identified the protective mechanism of AAEO on LPS‐induced liver injury at the level of small molecular metabolites, providing a potential liver protective agent for the treatment of LPS‐induced liver injury.
Exploring enablers and inhibitors of AI‐enabled drones for manufacturing process audits: A mixed‐method approach
Authors: Shankar Amit , Behl Abhishek , Pereira Vijay , Chavan Meena , Chirico Francesco 
Published: January 2024

AbstractThe objective of this study is to explore the enablers and inhibitors of AI‐enabled drone adoption for manufacturing process audit using a mixed‐method design. A qualitative study was performed to explore the enablers and inhibitors. Further, based on the findings of the qualitative studies, a framework was proposed, and proposed hypotheses were examined using a survey‐based study. The results indicated that function, environmental, and epistemic values are major enablers, whereas vulnerability and sunk cost barriers are major inhibitors to adoption intention. The initial trust and inertia were crucial mediators, and organizations' technological innovativeness played a crucial moderating role. This study enriches the literature on technological adoption for sustainability and helps audit service providers design strategies to enhance AI‐enabled drone adoption for process audits.
A protocol for a randomized trial evaluating the role of carbon‐ion radiation therapy plus camrelizumab for patients with locoregionally recurrent nasopharyngeal carcinoma
Authors: Hu Jiyi , Huang Qingting , Hu Weixu , Gao Jing , Yang Jing , Zhang Haojiong , Lu Jiade Jay , Kong Lin 
Published: January 2024

AbstractPurposeManagement of locoregionally recurrent nasopharyngeal carcinoma (LR NPC) is difficult. Although carbon‐ion radiation therapy (CIRT) could substantially improve the overall survival (OS) of those patients, around 40% of the patients may still develop local failure. Further improvement of the disease control is necessary. Immunotherapy, such as immune checkpoint inhibitors (ICIs) becomes a promising antitumor treatment. The role of ICIs was proved in head and neck cancers including recurrent/metastatic NPC. Preclinical studies indicated potential synergistic effects between radiation therapy and ICIs. Therefore, we conduct a randomized phase 2 trial to evaluate the efficacy and safety of camrelizumab, an anti‐PD‐1 monoclonal antibody, along with CIRT in patients with LR NPC.MethodsPatients will be randomly assigned at 1:1 to receive either standard CIRT with 63 Gy (relatively biological effectiveness, [RBE]) in 21 fractions, or standard CIRT plus concurrent camrelizumab. Camrelizumab will be administered intravenously with a dose of 200 mg, every 2 week, for a maximum of 1 year. We estimate addition of camrelizumab will improve the 2‐year progression‐free survival (PFS) from 45% to 60%. A total of 146 patients (with a 5% lost to follow‐up rate) is required to yield a type I error of 0.2, and a power of 0.8.Results and ConclusionThe results of the trial may shed insights on the combined therapy with ICIs and CIRT.
A prospective study of the relationship between illness perception, depression, anxiety, and quality of life in hematopoietic stem cell transplant patients
Authors: Ames Steven C. , Lange Lori , Ames Gretchen E. , Heckman Michael G. , White Launia J. , Roy Vivek , Foran James M. 
Published: January 2024

AbstractAimThe aim of study was to investigate whether depression and anxiety symptoms and illness perception prior to hematopoietic stem cell transplantation (HSCT) predict health related quality of life (HRQOL) at Day 100 and 1 year following HSCT.MethodsA total of 205 patients who underwent HSCT (N = 127 autologous transplants, N = 78 allogeneic transplants) were included in this prospective study. Baseline assessment was assessed prior to transplantation and post HSCT data were collected at Day 100 and 1 year. At baseline we assessed depressive symptoms (Patient Health Questionnaire‐9), anxiety symptoms (Generalized Anxiety Disorder‐7), illness perception (Brief Illness Perception Questionnaire), and HRQOL (Functional Assessment of Cancer Therapy‐BMT).ResultsPatients who expressed a greater level of concern about the severity, course, and ability to exert control over one's illness (i.e., illness perception) and who reported a greater level of depression and anxiety symptoms prior to HSCT reported lower HRQOL at both Day 100 and 1 year posttransplant, with a similar degree of association observed at the two follow‐up time points.ConclusionsOur findings suggest that pretransplant perceptions about their illness and negative mood are significant predictors of HRQOL following HSCT. Illness perception, depression, and anxiety are potentially modifiable risk factors for less than optimal outcome after HCSCT and intervention strategies should be explored.
Comprehensive Review on Herbal Medicine: Emphasis on Current Therapy and Role of Phytoconstituents for Cancer Treatment
Authors: Sharma Alok Nath , Dewangan Hitesh Kumar , Upadhyay Prabhat Kumar 
Published: January 2024

AbstractIntroduction: Cancer poses a significant public health challenge in both developed and developing nations, with a rising global incidence of patients facing the threat of death due to abnormal cell proliferation. Aim: Review explores the utilization of different parts of herbal medicinal plants and their active pharmaceutical constituents in the prevention and treatment of various types of cancer. Methodology: Various anticancer medicinal plants have been identified, demonstrating their therapeutic effects by inhibiting cancer‐stimulating enzymes and hormones, activating DNA repair processes, boosting the synthesis of protective stimulants, reducing the formation of free radicals, and enhancing individual immunity. Data for this study were gathered from diverse online bibliographic and databases, including Google, Google Scholar, Mendeley, Springer Link, Research Gate, and PubMed. Result: Herbal drugs have a huge contribution to the inhibition of the progression of cancer.A large volume of clinical studies has reported the beneficial effects of herbal medicines on the survival, immune modulation, and quality of life (QOL) of cancer patients, when these herbal medicines are used in combination with conventional therapeutics. Conclusion: The latest medicines for the clinical purpose (Above 50 %) are derived from herbal products. Furthermore, combination of these herbs with nanotechnology shows promise in treating specific carcinomas.
Flavonol Derivatives Containing a Quinazolinone Moiety: Design, Synthesis, and Antiviral Activity
Authors: Gong Chenyu , Meng Kaini , Sun Zhiling , Zeng Wei , An Youshan , Zou Hongqian , Qiu Yujiao , Liu Da , Xue Wei 
Published: January 2024

AbstractA series of flavonol derivatives containing quinazolinone were designed and synthesized, and their antiviral activities against tobacco mosaic virus (TMV) were evaluated. The results of the half maximal effective concentration (EC50) test against TMV showed that the EC50 value of curative activity of K5 was 139.6 μg/mL, which was better than that of the commercial drug ningnanmycin (NNM) 296.0 μg/mL, and the EC50 value of protective activity of K5 was 120.6 μg/mL, which was superior to that of NNM 207.0 μg/mL. The interaction of K5 with TMV coat protein (TMV‐CP) was investigated using microscale thermophoresis (MST) and molecular docking and the results showed that K5 can combine with TMV‐CP more strongly to TMV‐CP than that NNM can. Furthermore, the assay measuring malondialdehyde (MDA) content indicated that K5 had the ability to improve the disease resistance of tobacco. Hence, this study offers strong evidence that flavonol derivatives have potential as novel antiviral agents.
Illuminating the Path to Enhanced Bioimaging by Phosphole‐based Fluorophores
Authors: Schenk Mareike , König Nils , Hey‐Hawkins Evamarie , Beck‐Sickinger Annette G. 
Published: January 2024

AbstractAs the research of biological systems becomes increasingly complex, there is a growing demand for fluorophores with a diverse range of wavelengths. In this study, we introduce phosphole‐based fluorophores that surpass existing options like dansyl chloride. The reactive S−Cl bond in chlorosulfonylimino‐5‐phenylphosphole derivatives allows rapid and direct coupling to peptides making the fluorophores easily introducible to peptides. This coupling process occurs under mild conditions, demonstrated for [F7,P34]‐NPY and its shorter analogues. Peptides linked with our fluorophores exhibit similar receptor activation to the control peptide, while maintaining high stability and low toxicity, making them ideal biolabeling reagents. In fluorescence microscopy experiments, they can be easily visualized even at low concentrations, without suffering from the typical issue of bleaching. These phosphole‐based fluorophores represent a significant leap forward in the field. Their versatility, ease of modification, superior performance, and applicability in biological labeling make them a promising choice for researchers seeking advanced tools to unravel the details of complex biological systems.
A Look into the Boil‐Off Gas Reliquefaction in Propane Storage Plants
Authors: Panjehshahin Ahmad , Moradparsaei Mohammad , Bastan Farzad , Mohebi Somayeh , Dalvand Mohammadhossein 
Published: January 2024

AbstractThe reliquefaction process of boil‐off gas (BOG) in a propane plant using the reverse Brayton cooling cycle was examined by simulating the operational parameters and system performance of a propane reliquefaction plant in Aspen HYSYS software. The simulation considered various process and design parameters and their effects on the BOG production rate, energy consumption demand, and coefficient of performance (COP) of the cycle. The results demonstrate that the inclusion of methane in the propane product has a considerable impact on the generation of BOG, but this comes at a cost because power consumption increases significantly and the cycle's COP decreases. Furthermore, heat transmission from the surrounding air through the tank insulation and the temperature at which propane is returned from the jetty influence the BOG generation.
Mechanical ventilation core outcome set uptake in Cochrane systematic reviews: A cross‐sectional study
Authors: Garegnani Luis , Ivaldi Diego , Burgos Mariana , Oltra Gisela , Escobar Liquitay Camila M. 
Published: January 2024

AbstractIntroductionThe Cochrane Handbook acknowledges core outcome sets' (COS) relevance in defining review questions and planning systematic reviews. We aimed to assess the uptake of the mechanical ventilation (MV) COS in Cochrane systematic reviews of interventions.MethodsA cross‐sectional study. We included Cochrane systematic reviews and protocols of Cochrane systematic reviews of any intervention related to mechanically ventilated patients through a search in the Cochrane database of systematic reviews. We did not apply restrictions based on age or setting. One reviewer assessed the studies for eligibility and extracted data. Both processes were validated by a second author.ResultsWe identified 233 reviews and protocols through our search strategy. We finally included 36 records. Thirty‐four (94.44%) were Cochrane reviews and two (5.56%) were protocols. The included Cochrane reviews and protocols assessed a median of 13 (interquartile range [IQR]: 9–17) outcomes, with 35 (97.22%) reviews reporting at least one outcome from the MV COS. The median number of outcomes from the MV COS reported in the Cochrane reviews and protocols was 2.5 (IQR: 2–3). Only one (2.78%) study reported all the outcomes from the MV COS. None of the included Cochrane reviews and protocols cited the MV COS publication.ConclusionCompleted Cochrane systematic reviews and protocols of Cochrane systematic reviews of interventions related to mechanically ventilated patients have an overall limited uptake of the MV COS so far. Mortality and duration of stay were the most reported outcomes, while extubation and reintubation were the least informed. These findings may serve as a starting point for the Cochrane Critical Care community to develop dissemination strategies for improving the MV COS uptake.
CBe2H5−: Unprecedented 2σ/2π Double Aromaticity and Dynamic Structural Fluxionality in a Planar Tetracoordinate Carbon Cluster
Authors: Jin Bo , Yan Miao , Feng Lin‐Yan , Miao Chang‐Qing , Wang Ying‐Jin 
Published: January 2024

AbstractA 14‐electron ternary anionic CBe2H5− cluster containing a planar tetracoordinate carbon (ptC) atom is designed herein. Remarkably, it can be stabilized by only two beryllium atoms with both π‐acceptor/σ‐donor properties and two hydrogen atoms, which means that the conversion from planar methane (transition state) to ptC species (global minimum) requires the substitution of only two hydrogen atoms. Moreover, two ligand H atoms exhibit alternate rotation, giving rise to interesting dynamic fluxionality in this cluster. The electronic structure analysis reveals the flexible bonding positions of ligand H atoms due to C−H localized bonds, highlighting the rotational fluxionality in the cluster, and two CBe2 3c–2e delocalized bonds endow its rare 2σ/2π double aromaticity. Unprecedentedly, the fluxional process exhibits a conversion in the type of bonding (σ bond↔π bond), which is an uncommon fluxional mechanism. The cluster can be seen as an attempt to apply planar hypercoordinate carbon species to molecular motors.
Large‐Scale Production and Integrated Application of Micro‐Supercapacitors
Authors: Xie Yanting , Zhang Haitao , Hu Haitao , He Zhengyou 
Published: January 2024

AbstractMicro‐supercapacitors, emerging as promising micro‐energy storage devices, have attracted significant attention due to their unique features. This comprehensive review focuses on two key aspects: the scalable fabrication of MSCs and their diverse applications. The review begins by elucidating the energy storage mechanisms and guiding principles for designing high‐performance devices. It subsequently explores recent advancements in scalable fabrication techniques for electrode materials and micro‐nano fabrication technologies for micro‐devices. The discussion encompasses critical application domains, including multifunctional MSCs, energy storage integration, integrated power generation, and integrated applications. Despite notable progress, there are still some challenges such as large‐scale production of electrode material, well‐controlled fabrication technology, and scalable integrated manufacture. The summary concludes by emphasizing the need for future research to enhance micro‐supercapacitor performance, reduce production costs, achieve large‐scale production, and explore synergies with other energy storage technologies. This collective effort aims to propel MSCs from laboratory innovation to market viability, providing robust energy storage solutions for MEMS and portable electronics.
Probing the in‐plane dipole moment vector between ground and excited state of single molecules by the Stark effect
Authors: Smit Robert , Ristanović Zoran , Deperasińska Irena , Kozankiewicz Bolesław , Orrit Michel 
Published: January 2024

AbstractSingle molecules, embedded inside a well‐defined insertion site of a single‐crystalline host matrix, are sensitive probes of electric field via the induced Stark shift on their lifetime‐limited electronic transition. Though the response of molecules to electric field has been shown to be relatively homogeneous, crystal symmetry allows for several, spectroscopically‐indistinguishable, orientations of the net permanent dipole moment between the ground and excited state – the dipole vector – and this is problematic for measuring field orientation and magnitude. In this work, we measure for each terrylene molecule, embedded inside a new host matrix, the dipole vector independently by an electric field that we can rotate in the plane of the crystal. This single crystal host matrix, called [1]BenzoThieno[3,2‐b]BenzoThiophene, induces a moderate symmetry breaking of the embedded centrosymmetric terrylene molecule, and gives rise to a net dipole moment of 0.28±0.09 Debye. Based on quantum chemistry calculations we propose an insertion site that best matches the experimental findings.
A model predictive fault‐tolerant control strategy for non‐redundant T‐inverters with multiphysics‐circuit coupling loss analysis
Authors: Dou Zhifeng , Tian Ye , Zhang Changai , Gao Haorui , Lu Falong 
Published: January 2024

SummaryThis paper presents a multiobjective optimal power prediction fault‐tolerant control (MO2PPC) approach for mitigating DC link neutral‐point voltage imbalance and current ripple problems in three‐level T‐type inverter (3LT2I). Additionally, an auxiliary thyristor is employed to isolate and reconstruct the faulty phase into an 8ST2I for ensuring uninterrupted operation during phase failure. A method called injected bias current‐MO2PPC (IBC‐MO2PPC) fault‐tolerant strategy is proposed for this structure. This approach eliminates the need for DC or AC current sensors to reconstruct the three‐phase current, thereby reducing neutral‐point oscillation caused by phase deficiency and ensuring full power output after failure. Additionally, nonfaulty phase power loss is compared and analyzed to verify the stability of this method following a phase fault. The internal losses and temperature distribution of an IGBT module in a bridge arm before and after a fault are verified through a multiphysics‐circuit model in COMSOL‐Simulink coupling simulation presented last. The model shows reduced conduction losses and overall lower temperature distribution in the IGBT module after fault reconstruction. Experiments and multiphysics simulations have demonstrated that this approach displays exceptional robustness and sustainability throughout the entire fault cycle.
Trajectory of multimorbidity before dementia: A 24‐year follow‐up study
Authors: Guo Jing , Gao Bin , Huang Yun , Song Suhang 
Published: January 2024

AbstractINTRODUCTIONAlthough the multimorbidity–dementia association has been widely addressed, little is known on the long‐term trajectory of multimorbidity (TOM) in preclinical dementia.METHODSBased on the Health and Retirement Study, burden of multimorbidity was quantified with the total number of eight long‐term conditions (LTC). Patterns of TOM before dementia diagnosis were investigated with mixed‐effects models.RESULTSIn 1752 dementia cases and 5256 matched controls, cases showed higher and faster increasing predicted number of LTC than controls, with a significant case–control difference from 20 years prior to dementia diagnosis. Larger increases in number of LTC during preclinical phase of dementia were found in White participants, females, those whose age at dementia onset was younger, and those who were less educated.DISCUSSIONOur findings emphasize the faster accumulation of multimorbidity in prodromal dementia than in natural aging, as well as effect modifications by age and sex.Highlights
TOM increased faster in prodromal dementia than in natural ageing.
Patterns of TOM by dementia status diverged at 20 years before dementia diagnosis.
Patterns of TOM were modified by age and sex.
Long‐term outcomes and reverse remodelling in recently diagnosed unexplained left ventricular systolic dysfunction
Authors: Kuchynka Petr , Podzimkova Jana , Marek Josef , Danek Barbara Anna , Vitkova Ivana , Kreidlova Miluse , Roblova Lenka , Kovarnik Tomas , Simek Stanislav , Horak Jan , Habasko Jan , Linhart Ales , Palecek Tomas 
Published: January 2024

AbstractAimsIn patients with recently diagnosed non‐ischaemic LV systolic dysfunction, left ventricular reverse remodelling (LVRR) and favourable prognosis has been documented in studies with short‐term follow‐up. The aim of our study was to assess the long‐term clinical course and stability of LVRR in these patients.Methods and resultsWe prospectively studied 133 patients (37 women; 55 [interquartile range 46, 61] years) with recently diagnosed unexplained LV systolic dysfunction, with heart failure symptoms lasting <6 months and LV ejection fraction <40% persisting after at least 1 week of therapy. All patients underwent endomyocardial biopsy (EMB) at the time of diagnosis and serial echocardiographic and clinical follow‐up over 5 years. LVRR was defined as the combined presence of (1) LVEF ≥ 50% or increase in LVEF ≥ 10% points and (2) decrease in LV end‐diastolic diameter index (LVEDDi) ≥ 10% or (3) LVEDDi ≤ 33 mm/m2. LVRR was observed in 46% patients at 1 year, in 60% at 2 years and 50% at 5 years. Additionally, 2% of patients underwent heart transplantation and 12% experienced heart failure hospitalization. During 5‐year follow‐up, 23 (17%) of the study cohort died. In multivariate analysis, independent predictors of mortality were baseline right atrial size (OR 1.097, CI 1.007–1.196), logBNP level (OR 2.02, CI 1.14–3.56), and PR interval (OR 1.02, CI 1.006–1.035) (P < 0.05 for all). The number of macrophages on EMB was associated with overall survival in univariate analysis only. LVRR at 1 year of follow‐up was associated with a lower rate of mortality and heart failure hospitalization (P = 0.025). In multivariate analysis, independent predictors of LVRR were left ventricular end‐diastolic volume index (OR 0.97, CI 0.946–0.988), LVEF (OR 0.89, CI 0.83–0.96), and diastolic blood pressure (OR 1.04, CI 1.01–1.08) (P < 0.05 for all).ConclusionsLVRR occurs in over half of patients with recent onset unexplained LV systolic dysfunction during first 2 years of optimally guided heart failure therapy and then remains relatively stable during 5‐year follow‐up. Normalization of adverse LV remodelling corresponds to a low rate of mortality and heart failure hospitalizations during long‐term follow‐up.