bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case–Control Study
Authors: di Biase Lazzaro , Pecoraro Pasquale Maria , Di Lazzaro Vincenzo 
Published: January 2025

ObjectiveDespite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post‐mortem diagnosis. We evaluated the diagnostic accuracy of PD comparing the in‐vivo clinical diagnosis with the post‐mortem diagnosis performed through the pathological examination in 2 groups.MethodsIn this retrospective case–control study, patients and healthy subjects who consented to the post‐mortem pathological diagnosis at the UK Brain Bank were consecutively enrolled from the UK Brain Bank. Medical records were reviewed to classify participants and performance metrics were further calculated using neuropathological diagnosis as the gold standard.ResultsFour thousand five hundred seventy one subjects were eligible for the study. The clinical diagnosis group was: 1,048 Parkinson's patients and 1,242 healthy subjects. Pathology diagnosis group were: 996 Parkinson's patients and 1,288 subjects with no post‐mortem abnormality. For the group of clinical diagnosis, PD diagnosis showed: sensitivity of 99%, specificity of 86%, accuracy of 90.96%, F1‐Score 0.89, and a receiver operating characteristics area under the curve (ROC AUC) 0.925 (SE ± 0.006) [95% confidence interval [CI]: 0.913, 0.937], 𝑝<0.001. In this group, the most frequent pathology diagnosis among clinically misdiagnosed PD (false positive) patients was dementia with Lewy bodies (19.4%). Conversely, the most frequent clinical diagnosis among PD missed clinical diagnosis (false negative) patients was Alzheimer's disease (18.5%).InterpretationOur findings confirm a still significant diagnostic error and emphasize the need for more fine and homogeneous criteria to classify idiopathic Parkinson's patients correctly. ANN NEUROL 2025
Topological Supramolecular Complexation of Metal‐Organic Polyhedra for Tunable Interconnected Hierarchical Microporosity in Amorphous Form
Authors: Liu Yuan , Xue Binghui , Chen Jiadong , Cai Jinling , Yin Panchao 
Published: January 2025

AbstractThe precise engineering of microporosity is challenging due to the interference at the sub‐nm scale from unexpected structural flexibility and molecular packing. Herein, the concept of topological supramolecular complexation is proposed for the feasible fabrication of hierarchical microporosity with broad tunability in amorphous form. The 2.5 nm metal‐organic polyhedra (MOP) are complexed with quadridentate ligands through hydrogen and coordination bonding while the mismatch between the MOPs’ cuboctahedron and ligands’ tetrahedron topology leads to frustrated packing with extrinsic microporosity. Amorphous supramolecular frameworks can be obtained that integrate the intrinsic microporosity of the MOPs with the extrinsic porosity from the frustrated packing. The topologies, sizes and flexibility of ligands as well as ligand/MOP ratios are systemically varied, and the pore size distribution can be precisely adjusted. The hierarchical structures ranging from molecular packing to the morphologies of meso‐scale assemblies are probed using ultra‐small, small‐ and wide‐angle X‐ray scattering, enabling the quantitative evaluation of the micropores interconnectivity for the understanding of gas permeation performance. Gas separation membranes with permselectivity surpassing the Robeson upper bound can be designed. The findings not only give insight into the microscopic mechanism of supramolecular frustrated packing from topological design, but also pave new avenues for the cost‐effective fabrications of microporous frameworks.
Nanopore‐Based High‐Resolution Detection of Multiple Post‐Translational Modifications in Protein
Authors: Li Ziyi , Yi Yakun , Zhang Yun , Xiao Yuanyuan , Ren Qianyuan , Zhou Ke , Liu Lei , Wu Hai‐Chen 
Published: January 2025

AbstractProtein post‐translational modifications (PTMs) play crucial roles in various cellular processes. Despite their significance, only a few PTMs have been extensively studied at the proteome level, primarily due to the scarcity of reliable, convenient, and low‐cost sensing methods. Here, we present a straightforward and effective strategy for detecting PTMs on short peptides through host‐guest interaction‐assisted nanopore sensing. Our results demonstrate that the identity of 13 types of PTMs in a specific position of a phenylalanine‐containing peptide could be determined via current blockage during translocation of the peptide through α‐hemolysin nanopores in the presence of cucurbit[7]uril. Furthermore, we extend this strategy by incorporating a short peptide into the probe, enabling the discrimination of various PTMs, positional isomers, and even multiple PTMs on the target peptide. With ongoing improvements, our method holds promise for practical applications in sensing PTMs in biologically relevant samples, offering an efficient alternative to traditional mass spectrometry approaches.
Assessing Trends and Challenges: Insights From 30 Years of Monitoring and Management of Threatened Southern Atlantic Salmon Populations
Authors: García‐Vega Ana , Fuentes‐Pérez Juan Francisco , Bravo‐Córdoba Francisco Javier , Elso Josu , Ardaiz‐Ganuza José , Sanz‐Ronda Francisco Javier 
Published: January 2025

ABSTRACTThe Atlantic salmon (Salmo salar) has suffered significant population declines worldwide, prompting urgent conservation efforts, especially in its southern distribution area. This study is aimed at characterising the population dynamics of Atlantic salmon in the Bidasoa River (Spain), by focusing on fluctuations and long‐term trends in salmon returns, population characteristics and effects of angling and stocking activities. For this, monitoring data spanning three decades (1993–2023) from a salmon monitoring station and anglers' captures were used together with data on stocking activities provided by the Fish Management Section of the Navarre Government. Results reveal cyclical patterns driven by three distinctive wavelengths linked to the salmon life cycle, climatic variations and local habitat and connectivity improvements. The Bidasoa population was primarily dominated by one‐sea‐winter males returning during the autumn–winter season. Over the study period, a significant reduction in body size was observed, likely reflecting challenging marine conditions. Angling pressure was notably skewed towards multi‐sea‐winter females, which could influence natural recruitment dynamics. Despite the low mean stocking return rate of stocked salmon (0.13%), they contributed to one‐third of the annual returns, underscoring their potential role in supporting population persistence albeit at the expense of reducing natural spawning, amid broader ecological challenges. This study provides valuable insights into the complex interplay of ecological and anthropogenic factors affecting Atlantic salmon populations in southern European rivers. These insights are crucial for developing and implementing effective conservation strategies aimed at preserving the Atlantic salmon, a species of significant cultural and ecological importance.
Biofuel policies used by IEA Bioenergy Task 39 countries: the transition to using the carbon intensity (CI) of biofuels to set targets
Authors: Mohammadi Hana , Saddler Jack 
Published: January 2025

AbstractThe International Energy Agency (IEA) Bioenergy Task 39 countries share a collective ambition to decarbonize their transport sectors, with biofuels and ‘enabling’ policies playing a key role in achieving this goal. ‘Market‐pull’ and ‘technology‐push’ policies have been used successfully, with countries' targets often set using volumetric or energy content values. However, more recently, policies that address carbon emissions have increased in importance. For example, California's Low Carbon Fuel Standard has been pioneered at the state level and the USA's Inflation Reduction Act/ Renewable Fuels Standard and Europe's Renewable Energy Directives/RefuelEU policies have highlighted the importance of reducing the carbon intensity of biofuels. Although various policies will continue to be important if the transport sector is to decarbonize, technology‐agnostic policies that reduce the carbon intensity of fuels will become increasingly important. The work of IEA Bioenergy Task 39 has provided an international compare‐and‐contrast forum to assess biofuel policy development.
Mindfulness Practice and Work Performance: The Mediating Role of Emotional Intelligence and Psychological Capital
Authors: Long Hoang Cuu , An Ho Minh , Dung Pham Thi Phuong , Quy Nguyen Le Dinh 
Published: January 2025

ABSTRACTPurposeThe practice of mindfulness is becoming more widespread among employees, with potential benefits for workplace outcomes. However, there is a paucity of research on the mechanisms linking mindfulness to job performance.MethodThis study investigated the mediating functions of emotional intelligence and psychological capital in the relationship between mindfulness and job performance among 263 office employees in Ho Chi Minh City, Vietnam. The “mindfulness‐to‐meaning” viewpoint posits that through the practice of mindfulness, people are able to transcend negative emotions, gain a deeper understanding of themselves, and progress more intentionally by living more consciously in the present moment. Participants completed questionnaires measuring mindfulness, emotional intelligence, psychological capital, and occupational performance.FindingAccording to the results of structural equation modeling, mindfulness has a direct positive influence on job performance. In addition, emotional intelligence partially mediated the relationship between mindfulness and performance, as evidenced by a greater indirect effect than direct effect. However, the indirect effect via psychological capital was less significant than the direct effect of mindfulness. These findings identify emotional intelligence as a key personal resource that transmits the positive effects of mindfulness on workplace performance.ConclusionThe results advance comprehension of intermediary pathways in mindfulness research grounded in the resource‐based view. Integrating emotional intelligence training into mindfulness programs could increase employee productivity in organizations.
From Demand to Impact: Can Sustainable Banking Services Advance UN Sustainable Development Goals?
Authors: Taneja Shilpa , Siraj Ahsan , Mathiyazhagan Kaliyan , Khorana Sangeeta 
Published: January 2025

ABSTRACTIn response to growing climate change debate and sustainability concerns, business organizations must adopt relevant sustainable strategies aligning with the United Nations Sustainable Development Goals (UN‐SDGs). Extant research examines integration of sustainability in banking and finance, but demand‐side mechanisms influencing sustainable banking remain underresearched. With a mixed‐method approach, we analyse how consumers' adoption of sustainable banking services can be augmented in order to contribute to the SDG attainment. We develop a model that integrates theory of planned behaviour (TPB), value‐belief‐norm, and goal framing theory. Using focus group discussions and structural equation modelling, the results indicate that TPB variables, environment‐specific factors and altruistic values significantly influence adoption behaviour, with interesting mediating effects. We highlight the moderating role of biospheric, altruistic and hedonic values on linkage between intentions and behaviour. The study provides a comprehensive framework to assess demand‐side perspective of sustainable banking and offers insights to managers and policymakers on strategies for promoting these services for sustainable development.
Technological Advancement in Product Valorization of Agricultural Wastes Treated with Deep Eutectic Solvents: A Review
Authors: Quraishi Raushan , Haldar Dibyajyoti 
Published: January 2025

AbstractThe current review article investigates the potential for producing highly valuable items solely from agricultural wastes treated with deep eutectic solvents (DES). A thorough explanation of the DES s’ reaction mechanism and biomass‐treating capabilities is provided, shedding light on how green pretreatment methods can be applied to agricultural wastes in order to form high‐value products. In view of that, the influences of crucial properties of DES like viscosity, density, and recycling ability of DES are well analyzed. This review article's next goal is to compile the most recent developments for the years 2018–2023 on DES‐based valorization of agricultural wastes into a range of products, including biogas such as biohydrogen, liquid biofuels like bioethanol and butanol, and platform chemicals and reagents that are followed by novel materials. A discussion of the current criticalities and prospective avenues for further research concluded the paper. For this reason, having a thorough grasp of product value in one review paper from the potential of DES to agricultural wastes will be very helpful to the readers.
A Rare Case of Facial Arteriovenous Malformation in a 3‐Year‐Old Female
Authors: Pedun Bernadette , Pitua Ivaan , Bongomin Felix , Nabbosa Valeria , Bugeza Samuel 
Published: January 2025

ABSTRACTArteriovenous malformation (AVM) is a rare congenital vascular anomaly involving abnormal artery–vein connections that bypass the capillary system. AVMs are particularly uncommon in young children. A 3‐year‐old girl presented with a painless, progressively enlarging left cheek swelling since birth. Clinical examination showed left facial asymmetry with a nontender, pulsatile mass in the left parotid region without skin changes or visible collateral vessels. Computed tomography angiography revealed an enhancing mass in the left parotid region with feeding and draining vessels. The patient was referred to vascular surgery for further management. AVM's rarity in pediatrics highlights the need for further research in genetic and developmental factors, aiming to improve early detection, management, and outcomes for affected children.
Development of Triphenylamine Derived Photosensitizers for Efficient Hydrogen Evolution from Water
Authors: Wen Yudong , Fan Linyu , Yao Xiao , Ho Cheuk‐Lam 
Published: January 2025

AbstractA series of new (donor)₂‐donor‐π‐acceptor (D2‐D‐π‐A) and (acceptor)₂‐donor‐π‐acceptor (A2‐D‐π‐A) organic photosensitizers based on the framework of (Z)‐2‐cyano‐3‐(5‐(4‐(diphenylamino)phenyl)thiophen‐2‐yl)acrylic acid have been synthesized and characterized. By incorporating groups with different electron‐donating or withdrawing abilities, such as dibenzothiophene (DBT), dibenzofuran (DBF), and triazine (TA), into the triphenylamine segment, their photophysical properties have been regulated. Theoretical calculations were used to explore how various donor‐acceptor combinations influence their hydrogen production performance. Notably, DBF‐CN achieved the highest turnover number (TON) of 10,202 and an initial turnover frequency (TOFi) of 151.6 h−1 under green light irradiation, with an initial activity (Activityi) of 113,532 μmol g−1 h−1 and an apparent quantum yield (AQYi) of 0.76 %. This dye‐sensitized‐TiO2‐Pt system is recognized as one of the most efficient and durable systems for photocatalytic hydrogen production under green light irradiation, as described in the literature, when compared using TOF and TON values. Experimental results indicate that the D2‐D‐π‐A system significantly enhances photocatalytic hydrogen evolution (PHE) performance more effectively than the A2‐D‐π‐A system, while also maintaining stability under prolonged light exposure.
Artemisieverolides A—G, Sesquiterpenoid Trimers from Artemisia sieversiana and Their Antihepatic Fibrosis Activity
Authors: Weng Yan‐Mei , Li Tian‐Ze , Huang Xiao‐Yan , Li Qi‐Hao , Chen Rong‐Kai , Chen Ji‐Jun 
Published: January 2025

Comprehensive SummaryArtemisieverolides A—G (1—7), seven unreported sesquiterpenoid trimers, were isolated from Artemisia sieversiana (Asteraceae), and elucidated by comprehensive spectral data and electronic circular dichroism (ECD) calculations. Compounds 1, 2, 4 and 6 were unambiguously determined by the single‐crystal X‐ray diffraction. Artemisieverolide A (1) was an unprecedented guaianolide sesquiterpenoid trimer featuring a rare 5/7/4/7/5 carbon skeleton biogenetically derived from [2+2] cycloaddition and a 2‐methylbicyclo[2.2.1]‐2‐heptene ring through a Diels‐Alder (D‐A) reaction. Artemisieverolides B—G (2—7) were guaianolide sesquiterpenoid trimers generated by two D‐A reactions. Compounds 3, 4, and 5 exhibited inhibitory activities on the proliferation of HSC‐LX‐2 with the IC50 values of 52.6, 58.4, and 54.8 μmol/L, and were about 3 folds more active than silybin (IC50 = 149.4 μmol/L). Furthermore, compounds 2 and 7 suppressed the expression of collagen I in TGF‐β1‐stimulated HSC‐LX‐2.
ABT, Elacridar and Bile‐Duct Cannulated Rats: Tools to Understand Pharmacokinetics
Authors: Ouvry Gilles 
Published: January 2025

AbstractOptimizing pharmacokinetics is an integral part of drug design, albeit a lesser understood one from the medicinal chemist's perspective. Over the years, molecular tools and experimental strategies have been developed to better understand the fate of compounds. Among these, the use of aminobenzotriazole (ABT), elacridar and bile‐duct cannulated rats have been instrumental in gaining valuable PK insights, with a direct impact on drug design.
Efficacy and Safety of CART Cell Therapy in Aggressive B‐Cell Lymphomas Involving the Gastrointestinal Tract
Authors: Ma Lixia , Dou Yimeng , Liu Rui , Xu Teng , Yang Fan , Zheng Peihao , Feng Shaomei , Guo Yuelu , Shi Hui , Xue Fei , Deng Biping , Ke Xiaoyan , Hu Kai 
Published: January 2025

ABSTRACTObjectiveCurrently, chimeric antigen receptor T‐cell (CART) therapy represents a highly effective approach for relapsed/refractory B‐cell lymphomas. However, it also carries treatment‐related risks. Limited data are available on the risks associated with CART therapy in patients with gastrointestinal involvement in B‐cell lymphomas. Therefore, we conducted a retrospective cohort study to address this gap in knowledge.MethodsDuring the period from May 2019 to August 2022, a total of 26 patients recurrent/refractory with recurrent/refractory B‐cell lymphoma involving the gastrointestinal tract enrolled. Pathology confirmed CD19 antigen expression in tumor tissues. The disease status of patients who failed multiple lines of therapy was progressive disease (PD). Before CART cell infusion, patients received an FC regimen (fludarabine and cyclophosphamide) lymphodepletion. Quantitative PCR and flow cytometry were adopted for monitoring CART cell kinetics and function, with a focus on gastrointestinal AEs during treatment. The overall response rate (ORR) of the 26 patients was 61.5% (16/26), while the complete response rate (CR) was 23.1% (6/26). Their median follow‐up time was 22.49 months, while the medians of overall survival (OS) and progression‐free survival (PFS) were 10.88 and 5.47 months, respectively. The 1‐year OS and PFS rates were 45% and 42.3%, respectively. The prevalence of gastrointestinal complications was 21/26 (80.7%), including gastrointestinal hemorrhage in 11/26 (42.3%), emesis and diarrhea in 9/26 (34.6%), as well as intestinal obstruction in 2/26 (7.7%). A total of three patients (3/26, 11.5%) died of gastrointestinal hemorrhage. The gastrointestinal hemorrhage group exhibited markedly lower ORR and inferior OS compared to the non‐hemorrhage group.ConclusionGenerally, the CART cell therapy is valid in relapsed/refractory B‐cell lymphoma with gastrointestinal involvement, but gastrointestinal bleeding is a unique risk factor that requires special attention, particularly in patients with high gastrointestinal tumor burden, as it is associated with poor efficacy and survival.
A 300 kyr record of past hydroclimate change from alluvial fans in the southern Central Andes
Authors: D'Arcy Mitch K. , Schildgen Taylor F. , Bonnet Stéphane , Duesing Walter , Tofelde Stefanie , Roda‐Boluda Duna C. , Wittmann Hella , Mey Jürgen , Murray Andrew S. , Alonso Ricardo N. , Strecker Manfred R. 
Published: January 2025

AbstractAlluvial fans are hypothesised to record signals of past hydroclimate changes in their depositional chronologies and slopes. However, direct tests of this hypothesis have been limited due to challenges in precisely dating the responses of alluvial fans to past climate forcing. Here, we present a new chronology of alluvial‐fan deposition at the Sierra de Aconquija in the southern Central Andes (27°S) spanning ~300 kyr and based on 35 cosmogenic 10Be‐derived exposure ages and eight infrared‐stimulated (IRSL) and optically stimulated luminescence (OSL) ages. The ages reveal that fan deposition was phased with past climate changes. Orbitally‐forced weakening and strengthening of the South American Summer Monsoon coincided with fan aggradation during dry episodes and incision during wetter episodes, consistent with predictions from alluvial‐channel models. These results are in precise agreement with independent palaeoclimate constraints spanning timescales of 103 to 105 years. Fan aggradation‐incision cycles record a predominant influence of precession‐induced variations in precipitation, although climate shifts as rapid as 1 kyr also triggered incision, and fan architecture appears to be further modulated by orbital eccentricity cycles. Incision events on the fans coincide with the ages of moraines in the headwater catchments, including those formed during the Younger Dryas and Last Glacial Maximum. Furthermore, the fan chronology indicates dry conditions in the southern Central Andes during Heinrich Stadial 1, suggesting that enhanced precipitation during this episode was limited to more northerly latitudes. Our results demonstrate that climate change exerts a primary control on simple, source‐to‐sink sedimentary systems and show that alluvial fans can, in some cases, be utilised as terrestrial palaeoclimate archives with which the spatio‐temporal variability of past climate changes can be constrained.