bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corynebacterium oculi-related bacterium may act as a pathogen and carrier of antimicrobial resistance genes in dogs: a case report
Authors: Tresch Milena , Watté Christine , Stengard Michele , Ritter Corinne , Brodard Isabelle , Feyer Simon , Gohl Estelle , Akdesir Ezgi , Perreten Vincent , Kittl Sonja 
Published: November 2023

Abstract
Background
The genus Corynebacterium comprises well-known animal and human pathogens as well as commensals of skin and mucous membranes. Species formerly regarded as contaminants are increasingly being recognized as opportunistic pathogens. Corynebacterium oculi has recently been described as a human ocular pathogen but has so far not been reported in dogs.

Case presentation
Here we present two cases of infection with a novel Corynebacterium sp., a corneal ulcer and a case of bacteriuria. The two bacterial isolates could not be identified by MALDI-TOF MS. While 16 S rRNA gene (99.3% similarity) and rpoB (96.6% identity) sequencing led to the preliminary identification of the isolates as Corynebacterium (C.) oculi, whole genome sequencing revealed the strains to be closely related to, but in a separate cluster from C. oculi. Antimicrobial susceptibility testing showed high minimal inhibitory concentrations of lincosamides, macrolides, tetracycline, and fluoroquinolones for one of the isolates, which also contained an erm(X) and tet-carrying plasmid as well as a nonsynonymous mutation leading to an S84I substitution in the quinolone resistance determining region of GyrA.

Conclusions
While the clinical signs of both dogs were alleviated by antimicrobial treatment, the clinical significance of these isolates remains to be proven. However, considering its close relation with C. oculi, a known pathogen in humans, pathogenic potential of this species is not unlikely. Furthermore, these bacteria may act as reservoir for antimicrobial resistance genes also in a One Health context since one strain carried a multidrug resistance plasmid related to pNG3 of C. diphtheriae.
The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study
Authors: Wang Liping , Nie Guqiao , Yan Fengqin , Zhou Nianli , Zhang Meng , Peng Wen 
Published: November 2023

Abstract
Background
The ZJU index, a novel calculation that combines body mass index, triglycerides, fasting blood glucose and the ratio of alanine aminotransferase to aspartate aminotransferase, is a closely related measure of obesity and insulin resistance. Studies of the ZJU index in relation to obstructive sleep apnea syndrome (OSAS) have not been reported. This study assessed the correlation between the ZJU values and OSAS risk.

Methods
A total of 2,130 participants who underwent polysomnographic monitoring were included in the study. The participants’ basic information and laboratory biochemical indicators were collected, and the ZJU index was computed. The ZJU index was divided into quartiles. The correlation between the different ZJU index levels and OSAS risk was assessed using logistic regression. Drew a receiver operating characteristic (ROC) relationship curve, with prediction efficacy judged by the area under the curve (AUC), and found the optimum cut-off point for ZJU index to predict OSAS. Relative risks were presented as odds ratios (OR). The range of OR values is expressed in the form of 95% confidence intervals (95% CI).

Results
The number of patients diagnosed with OSAS increased progressively with increasing ZJU index (T1: 9.4%; T2: 20.6%; T3: 28.3%; T4: 41.7%; P < 0.001). The additional confounders were adjusted by the logistic regression models, the study revealed an independent correlation between ZJU index and OSAS. (P < 0.001). The OSAS risk was notably higher at the highest ZJU index levels. (OR = 2.046 [95% CI: 1.057 to 3.964]). The ROC curve for the ZJU index showed an AUC of 0.64 (P < 0.001) for males and 0.75 (P < 0.001) for females, with a specificity of 64% and 55% and a sensitivity of 60% and 92% for males and females, respectively, with the optimum cut-off values of 36.568 and 34.722, respectively.

Conclusion
A high ZJU index was significantly associated with an increasing risk of OSAS. The ZJU is expected to be a meaningful index for detecting OSAS in the general population.
DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy
Authors: Zhang Liang , Xia Chenhai , Yang Yongjun , Sun Fangfang , Zhang Yu , Wang Huan , Liu Rui , Yuan Ming 
Published: November 2023

AbstractAtherosclerosis, which is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls, acts as the important cause of most cardiovascular diseases. Except for a lipid-depository and chronic inflammatory, increasing evidences propose that epigenetic modifications are increasingly associated with atherosclerosis and are of interest from both therapeutic and biomarker perspectives. The chronic progressive nature of atherosclerosis has highlighted atherosclerosis heterogeneity and the fact that specific cell types in the complex milieu of the plaque are, by far, not the only initiators and drivers of atherosclerosis. Instead, the ubiquitous effects of cell type are tightly controlled and directed by the epigenetic signature, which, in turn, is affected by many proatherogenic stimuli, including low-density lipoprotein, proinflammatory, and physical forces of blood circulation. In this review, we summarize the role of DNA methylation and histone post-translational modifications in atherosclerosis. The future research directions and potential therapy for the management of atherosclerosis are also discussed.
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Authors: Wu Zeyu , Yu Xiao , Zhang Shuijun , He Yuting , Guo Wenzhi 
Published: November 2023

AbstractNon-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regulating cell cycle, cell proliferation, and intracellular substance metabolism. Piwi-interacting RNAs (piRNAs) are emerging small non-coding RNAs that are 24–31 nucleotides in length. Previous studies on piRNAs were mainly limited to evaluating the binding to the PIWI protein family to play the biological role. However, recent studies have shed more lights on piRNA functions; aberrant piRNAs play unique roles in many human diseases, including diverse lethal cancers. Therefore, understanding the mechanism of piRNAs expression and the specific functional roles of piRNAs in human diseases is crucial for developing its clinical applications. Presently, research on piRNAs mainly focuses on their cancer-specific functions but lacks investigation of their expressions and epigenetic modifications. This review discusses piRNA’s biogenesis and functional roles and the recent progress of functions of piRNA/PIWI protein complexes in human diseases.
C–C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model
Authors: Liu Yun-Hui , Zhu Lin , Zhang Zhong-Wei , Liu Ting-Ting , Cheng Qiu-Yu , Zhang Meng , Niu Yu-Xin , Ding Lin , Yan Wei-Ming , Luo Xiao-Ping , Ning Qin , Chen Tao 
Published: November 2023

Abstract
Background
Previous studies have demonstrated that natural killer (NK) cells migrated into the liver from peripheral organs and exerted cytotoxic effects on hepatocytes in virus-induced liver failure.

Aim
This study aimed to investigate the potential therapeutic role of chemokine receptors in the migration of NK cells in a murine hepatitis virus strain 3 (MHV-3)-induced fulminant hepatic failure (MHV-3-FHF) model and its mechanism.

Results
By gene array analysis, chemokine (C–C motif) receptor 5 (CCR5) was found to have remarkably elevated expression levels in hepatic NK cells after MHV-3 infection. The number of hepatic CCR5+ conventional NK (cNK) cells increased and peaked at 48 h after MHV-3 infection, while the number of hepatic resident NK (rNK) cells steadily declined. Moreover, the expression of CCR5-related chemokines, including macrophage inflammatory protein (MIP)-1α, MIP-1β and regulated on activation, normal T-cell expressed and secreted (RANTES) was significantly upregulated in MHV-3-infected hepatocytes. In an in vitro Transwell migration assay, CCR5-blocked splenic cNK cells showed decreased migration towards MHV-3-infected hepatocytes, and inhibition of MIP-1β or RANTES but not MIP-1α decreased cNK cell migration. Moreover, CCR5 knockout (KO) mice displayed reduced infiltration of hepatic cNK cells after MHV-3 infection, accompanied by attenuated liver injury and improved mouse survival time. Adoptive transfer of cNK cells from wild-type mice into CCR5 KO mice resulted in the abundant accumulation of hepatic cNK cells and aggravated liver injury. Moreover, pharmacological inhibition of CCR5 by maraviroc reduced cNK cell infiltration in the liver and liver injury in the MHV-3-FHF model.

Conclusion
The CCR5-MIP-1β/RANTES axis played a critical role in the recruitment of cNK cells to the liver during MHV-3-induced liver injury. Targeted inhibition of CCR5 provides a therapeutic approach to ameliorate liver damage during virus-induced acute liver injury.
Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics
Authors: Zhang Tianyi , Yang Sheng , Ge Yiling , Wan Xin , Zhu Yuxin , Yang Fei , Li Jie , Gong Saisai , Cheng Yanping , Hu Chengyu , Chen Zaozao , Yin Lihong , Pu Yuepu , Liang Geyu 
Published: November 2023

Abstract
Background
Nanoplastics (NPs) could be released into environment through the degradation of plastic products, and their content in the air cannot be ignored. To date, no studies have focused on the cardiac injury effects and underlying mechanisms induced by respiratory exposure to NPs.

Results
Here, we systematically investigated the cardiotoxicity of 40 nm polystyrene nanoplastics (PS-NPs) in mice exposed via inhalation. Four exposure concentrations (0 µg/day, 16 µg/day, 40 µg/day and 100 µg/day) and three exposure durations (1 week, 4 weeks, 12 weeks) were set for more comprehensive information and RNA-seq was performed to reveal the potential mechanisms of cardiotoxicity after acute, subacute and subchronic exposure. PS-NPs induced cardiac injury in a dose-dependent and time-dependent manner. Acute, subacute and subchronic exposure increased the levels of injury biomarkers and inflammation and disturbed the equilibrium between oxidase and antioxidase activity. Subacute and subchronic exposure dampened the cardiac systolic function and contributed to structural and ultrastructural damage in heart. Mechanistically, violent inflammatory and immune responses were evoked after acute exposure. Moreover, disturbed energy metabolism, especially the TCA cycle, in the myocardium caused by mitochondria damage may be the latent mechanism of PS-NPs-induced cardiac injury after subacute and subchronic exposure.

Conclusion
The present study evaluated the cardiotoxicity induced by respiratory exposure to PS-NPs from multiple dimensions, including the accumulation of PS-NPs, cardiac functional assessment, histology observation, biomarkers detection and transcriptomic study. PS-NPs resulted in cardiac injury structurally and functionally in a dose-dependent and time-dependent manner, and mitochondria damage of myocardium induced by PS-NPs may be the potential mechanism for its cardiotoxicity.

Graphical abstract
Fourth-order fitted mesh scheme for semilinear singularly perturbed reaction–diffusion problems
Authors: Reda Birtukan Tebabal , Bullo Tesfaye Aga , Duressa Gemechis File 
Published: November 2023

Abstract
Objective
The main purpose of this work is to present a fourth-order fitted mesh scheme for solving the semilinear singularly perturbed reaction–diffusion problem to produce more accurate solutions.

Results
Quasilinearization technique is used to linearize the semilinear term. The scheme is formulated with discretizing the solution domain piecewise uniformly and then replacing the differential equation by finite difference approximations. This gives the system of difference algebraic equations and is solved by the Thomas algorithm. Convergence analysis are investigated using solution bound and the truncation error bound. Numerical illustrations are investigated to support the theoretical results and the method’s applicability. The method produces a more accurate solution than some existing methods in the literature.
Initiation of multiple-session psychological care in civilians exposed to the November 2015 Paris terrorist attacks
Authors: Pirard Philippe , Motreff Yvon , Stene Lise Eilin , Rabet Gabrielle , Vuillermoz Cécile , Vandentorren Stéphanie , Baubet Thierry , Messiah Antoine 
Published: November 2023

Abstract
Background
Terrorist attacks can induce post-traumatic stress disorder (PTSD) and depression, which require multiple-session psychological care (MSPC). This study aims at investigating MSPC initiation and associated factors.

Methods
Data were collected from a web-based survey of civilians 8–12 months after their exposure to the November 2015 Paris terrorist attacks. Depression and partial and full PTSD were assessed using the Hospital Anxiety and Depression Scale and the PCL-5 checklist, respectively. Questionnaires collected data on socio-demographic variables, exposure to the attacks, psychological treatment history, social isolation, somatic problems, having received an outreach psychological support (OPS), consultations with a general practitioner, contact with an association for victims, MSPC initiation and, if not, reasons for not having initiated it. Logistic regressions were used to examine factors associated with MSPC initiation.

Results
Among the 450 respondents, 154 reported having initiated a MSPC after the attacks. Of the 134 who provided the MSPC initiation date, 50% did so during the first month. Among the respondents with at least one of the considered psychological disorders, 53% declared not having initiated yet a MSPC. The primary three reasons for not having initiated a MSPC among people with PTSD were “did not feel the need”, “it was not the right time to talk about it”, and “not offered”. For people with at least one psychological disorder, MSPC initiation was associated with the number of somatic problems, type of exposure (witness, threatened, indirectly exposed), prior psychological treatment, being a woman, being in a relationship, having consulted a psychiatrist or a psychologist, having received an OPS, and being in contact with association for victims.

Conclusion
The organization of adequate psychological care after a terror attack must take into account the need for healthcare that may emerge several months after the attack, and that witnesses seem less likely to receive MSPC than persons directly threatened despite their psychological disorder. Associations for victims and OPS seem to facilitate access to MSPC. Furthermore, our findings highlight the need to train physicians to screen for psychological disorders in persons exposed to terrorist attacks who present with somatic disorders.
Words You Burn Down: Toward a Poetics of Umfarshtandlekh Translation
Authors: Resnikoff Ariel 
Published: November 2023

Abstract
The present work addresses the deep intertangled poetic kithship between the Jewish German-language poet Paul Celan (1920 – 70) and his most prolific translator, the contemporary translingual American poet, Pierre Joris (b. 1946). Taking Joris's recent and final translated volume of Celan's poetry — Memory Rose into Threshold Speech (2020) — as its discursive perch, this essay constellates various key interlocutors between the two poets and examines Joris's tremendous half-century-long feat in translating Celan into an American idiom. The force and ultimate lasting power of Joris's translation project lies in its rare ability to hold and behold in English the mutilated music of Celan's umfarshtandlekh (incomprehensible) poetics, itself a form of German reimagined through a post-Holocaust expanded Yiddish.
Law's Numbers
Authors: Alvarez-Nakagawa Alexis 
Published: November 2023

Abstract
Albert Woodfox's Solitary, a memoir of four decades in solitary confinement, is a painful testimony of the violence of criminal justice and dramatic evidence of survival. This review essay considers Woodfox's account and contends that today African Americans live in a suffocating state displayed in law's numbers: high incarceration rates, police brutality, and summary killings. It argues against viewing Woodfox's testimony as a redemption story so as not to undermine its transformative power. To bring solitary confinement to an end, one must acknowledge that there is no reversal to the damage caused by law's numbers.
Havertz, Ralf. Radical right populism in Germany: AfD, Pegida, and the identitarian movement. New York: Routledge, 2021, 202p. ISBN: 978-0-367-37146-3
Authors: Oppermann Daniel 
Published: November 2023

A direita e o populismo radical de direita ganharam terreno em vários países nos últimos anos. Enquanto os populistas de direita chegaram ao poder em alguns países, outros viram uma presença de populistas de direita nos parlamentos e nas ruas durante anos. Este livro é um estudo de caso de organizações populistas de direita na Alemanha, enfocando especialmente o partido Alternativa para a Alemanha (AfD).Palavras-chave: Populismo. Alemanha. AfD.ABSTRACTRight-wing and radical right populism has gained ground in various countries in recent years. While right-wing populists have come to power in some countries, other countries have seen a presence of right-wing populists in parliaments and on the streets for years. This book is a case study of right-wing populist organizations in Germany, focusing mostly on the party Alternative for Germany (AfD).Keywords: Populism. Germany. AfD. Recebido em: 13 nov. 2022 | Aceito em: 17 mai. 2023.
Dental advice for children and young people with congenital heart disease: a survey of cardiac nurses
Authors: Dervish Aylen , Vaidyanathan Mina , Gaskin Kerry 
Published: November 2023

Background/Aims Optimum oral healthcare and dental education is vital for children and young people with congenital heart disease to reduce the risk of infective endocarditis. The aims of this study were to ascertain the information provided by cardiac nurses regarding preventative dental care for children and young people with congenital heart disease and their families. Methods Data about preventative dental advice were collected via a cross-sectional online survey of children and young people's cardiac nurses, conducted from November 2021–March 2022 and October–November 2022. A snowball sampling method was used to recruit respondents for the study, resulting in responses from 27 cardiac nurses across seven cardiac networks in England. Results Of the 27 participants, 24 (88.9%) gave dental advice to patients and their families, 21 (77.8%) and were moderately or highly confident about providing advice, but just over half (n=14, 51.9%) were unaware of national congenital heart disease dental standards. Three themes emerged from analysis of the survey: educational needs, resource availability and empowerment. Conclusions Despite the relatively low response rate, inconsistencies in the implementation of cardiac standards among different networks were evident. Recommendations include improving access to dental services, improving collaboration between dental and cardiac teams, providing dental education for children and young people's cardiac nurses and giving correct advice to parents to promote optimum dental health for this high-risk group.
Associations of serum keratin 1 with thyroid function and immunity in Graves’ disease
Authors: Cheng Chao-Wen , Fang Wen-Fang , Lin Jiunn-Diann 
Published: November 2023

Background
Autoimmune thyroid disease (AITD) can cause enormous health burdens; however, trustworthy biomarkers in identifying the onset and progression of AITD are limited. In this study, we attempted to discover new potential serum biomarkers to discriminate AITD using mass spectrometry (MS).

Methods
In the biomarker study cohort, 20 patients with Graves’ disease (GD), 20 patients with Hashimoto’s thyroiditis (HT), and 20 healthy controls were enrolled for a liquid chromatographic-tandem MS assessment. A novel biomarker, keratin 1 (KRT1), was selected for further evaluation in the validation cohort, including 125 patients with GD, 34 patients with HT, and 77 controls. Relationships of serum KRT1 with AITD-related immunomodulatory cytokines were also analyzed using enzyme-linked immunosorbent assays (ELISAs).

Results
In the MS analysis, KRT1 was the single marker overexpressed in GD, while it was underexpressed in HT. In the ELISA analysis of the validation cohort, KRT1 was consistently upregulated in GD, while it was not downregulated in HT. There were significant associations of KRT1 levels with thyroid function in GD, AITD, and overall subjects. Additionally, a significant association of KRT1 levels with thyroid-stimulating hormone receptor antibody (TSHRAb) levels was observed. Moreover, there were significant associations of KRT1 with osteopontin (OPN) and B-cell activating factor (BAFF) levels in GD.

Conclusions
Serum KRT1 levels were upregulated in GD and were associated with thyroid function and TSHRAb levels. Moreover, KRT1 was correlated with the BAFF and OPN levels in GD patients. Further molecular-based research to elucidate the role of KRT1 in the pathogenesis of AITD is needed.
Causal association between dietary factors and esophageal diseases: A Mendelian randomization study
Authors: Zou Menglong , Liang Qiaoli , Zhang Wei , Zhu Ying , Xu Yin 
Published: November 2023

Background
Using Mendelian randomization (MR) approach, our objective was to determine whether there was a causal association between dietary factors and gastroesophageal reflux disease (GERD), Barrett’s esophagus (BE), or esophageal cancer (EC).

Methods
Genome-wide association study (GWAS) data for eighteen types of dietary intake were obtained from the UK Biobank. GWAS data for GERD, BE, and EC were sourced from the FinnGen consortium. We performed univariable and multivariable MR analysis to assess the cause effect between dietary factors and esophageal diseases. MR results were expressed as odds ratios (OR) with 95% confidence intervals (CI).

Results
Raw vegetable intake was associated with a lower risk of GERD (OR = 0.478; P = 0.011). On the contrary, cooked vegetable intake increased the risk of GERD (OR = 1.911; P = 0.024). Bread intake was associated with increased odds of BE (OR = 6.754; P = 0.007), while processed meat intake was associated with reduced risk of BE (OR = 0.210; P = 0.035). We also observed evidence that increased consumption of dried fruit (OR = 0.087; P = 0.022) and salt added to food (OR = 0.346; P = 0.045) could prevent EC. The results of multivariable MR showed that the protective effect of consumption of salt added to food on EC was no longer significant after adjusting for the consumption of dried fruit.

Conclusion
Vegetable consumption was associated with GERD, whereas consumption of bread and processed meat was associated with BE. Dried fruit intake was associated with a lower risk of EC, and the protective effect of consumption of salt added food on EC may also be mediated by consumption of dried fruit. Future research should be performed to investigate the mechanisms behind these cause-and-effect relationships to reduce the burden of disease caused by dietary habits.