bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of office light environment on mental health interventions for employees: An investigative analysis
Authors: Jiao Dian , Zhao Mingzhe , Tang Jian , Dazhuang Lu 
Published: February 2025

Background The increasing prevalence of work-related stress and mental health issues has become a global concern, particularly in developing countries. The light environment in office spaces, known to influence both visual and non-visual aspects of health, is a critical factor that needs further exploration for its potential in enhancing employees’ psychological well-being. Objective The aim of our study was to investigate the role of light environments in office spaces in influencing the psychological well-being of employees. Methods The study was conducted in 2 office locations in Shanghai and Dalian, China and analyzed data from 235 employees. Data on the effects of the light environment were self-reported by the participants, and the psychological well-being of the employees was measured on 2 dimensions (differences in color perception, and differences in perception between natural dynamic lighting and artificial static lighting). The effects of hue and lightness on employee psychology, and the effects of natural versus conventional static lighting on employee mood were analyzed. Results The findings revealed that the hue and luminance of office spaces significantly affect employees’ psychological satisfaction and emotional states. Specifically, natural dynamic lighting, which aligns with the natural photoperiod, was found to effectively reduce negative emotions such as anger and depression, offering a promising intervention for improving mental health in the workplace. Conclusions The light environment in office settings plays a significant role in mitigating mental health issues among employees. While the study confirms the positive effects of dynamic lighting on mental health, it also highlights the need for further interdisciplinary research to fully understand the complex mechanisms involved.
The effect of humanistic behavior skills in nursing practice on caregiving competence
Authors: Kaplan Mehmet , Kaplan Feride , Çelik Hanife 
Published: February 2025

Background The need for care of patients is increasing day by day as societies age. In parallel with the increase in the need for care, the adequacy of the care provided and the factors affecting it gain importance. Objective This study aims to determine the effect of nurses’ humanistic behavior skills on caregiving competence and the factors affecting it. Methods The study sample consisted of 445 nurses working in a state hospital and selected by random sampling method. The study data were collected between January and April 2023. Face-to-face interview method was used to collect the data. The questionnaire application was conducted in a period of approximately 15–20 min. The nurse information form including demographic characteristics, the humanistic behavior skills in nursing practice scale (HPAN) and the caregiving competence scale were used to collect the data. Results The nurses’ humanistic behavior skills affected their caregiving competence by 0.082. HPAN and age had an effect size of 0.084 on caregiving competence; HPAN, age and gender had an effect size of 0.124 in the triad model; HPAN, age, gender and average overtime worked in a month had an effect size of 0.136 in the quad model. Conclusions It was determined that as the humanistic behavior skills of the nurses increased, their caregiving competence also improved. The humanistic behavioral skills of the nurses affect care giving competence at a rate of 8.2%. In addition, age, gender, overtime work and working years also affect care giving competence.
Early Experience With the Nexus Aortic Arch Endograft for Endovascular Treatment of Complex Aortic Arch Pathologies Beyond Standard Indications
Authors: Bisdas Theodosios , Zambas Neophytos , Zertalis Marios , Kanellopoulos George , Roubelakis Apostolos , Georghiou Georgios P. , Pappas Stylianos , Theodoridis Panagiotis , Dimopoulos Christos , Iatrou Nikolaos , Charalambous Nikolas 
Published: February 2025

Background: The Nexus stent graft offers a minimally-invasive option for treating aortic arch aneurysms (AArA). Despite strict instructions for use (IFU), it is sometimes applied in complex anatomies for patients who are surgically inoperable or unsuitable for other devices. This study evaluates outcomes in patients treated outside the IFU, providing real-world insights. Methods: We analyzed patients treated with the Nexus endograft outside its IFU between January 2022 and August 2024. The primary endpoint was the occurrence of major adverse cardiovascular and cerebral events (MACCE) such as death, stroke, or myocardial infarction. Secondary endpoints included the reasons for outside-IFU implantation, technical success, any aortic-related adverse events and postoperative endoleaks. Results: Thirteen patients underwent endovascular treatment for AArA outside IFU. Five (38.5%) had a post-type A dissection, 5 had de novo AArA (38.5%), and 3 (23%) lacked a landing zone in zones 1 to 3 of the aortic arch for thoracoabdominal aortic repair. Seven patients (54%) received the Nexus One device, while 6 (46%) received the Nexus Duo endograft. No perioperative MACCE occurred. Mean follow-up was 17 ± 12 months, with a 79% survival rate at 1 year. Primary reasons for outside IFU use included an inner ascending length <30 mm and a descending aortic diameter >40 mm in 46% of patients accordingly. Technical success was achieved in all cases. A type Ic endoleak (7%) due to aneurysmatic degeneration of the brachiocephalic artery was identified at 2 years. No further aortic-related adverse events were reported. Conclusions: The Nexus endograft demonstrated a favorable safety profile and promising clinical outcomes at 1 year, even in patients treated outside IFU criteria, with high technical success and no evidence of stroke. Reassessment of certain IFU criteria could enhance the device’s applicability. Clinical Impact Our findings highlight the potential for expanding the clinical use of the Nexus stent-graft beyond its current IFU, offering a safe and effective alternative for complex aortic arch anatomies. With high technical success and no perioperative cerebrovascular events, these results suggest that carefully selected patients who are otherwise ineligible for surgery may still benefit from endovascular repair. This study provides real-world evidence supporting the reconsideration of IFU criteria, potentially broadening treatment options. The innovation lies in demonstrating that even outside IFU conditions, the Nexus endograft maintains a strong safety profile, paving the way for more inclusive patient selection.
Continuous Glucose Monitoring in Hospitalized Adults With Diabetic Ketoacidosis: A Prospective Open-Label Pilot Study
Authors: Bogun Magdalena M. , Wang Chunhui , Kurlansky Paul A. , Bedeir Nur , Umpierrez Guillermo E. 
Published: February 2025

Background: Continuous glucose monitoring (CGM) devices are increasingly used in critical and non-critical care hospital units. The efficacy of CGM in assessing glucose control in adults with diabetic ketoacidosis (DKA) is unknown. Methods: This single-center pilot study compared glycemic control by real-time CGM (Dexcom G6), capillary point-of-care (POC), and basic metabolic panel (BMP) during intravenous (IV) insulin treatment and after the resolution of DKA. We compared the mean absolute relative difference (MARD), median absolute relative difference (ARD) glucose values, and Diabetes Technology Society (DTS) Error Grid analyses. Results: We recruited 52 patients (49 ± 19 years, admission glucose: 503 ± 239.4 mg/dL) with type 1 diabetes (n = 24) and type 2 diabetes (n = 28). Compared with POC testing, the MARD was 17.4% ± 13.2%, and the median ARD was 14.2% (interquartile range [IQR]: 6.4, 28) during the initial IV insulin period and 19.8% ± 18.7% and 14.3% (7, 26.2) after DKA resolution. The DTS Error Grid analysis showed that 100% of values during the IV insulin treatment and 95% after the DKA resolution were in zones A+B. Compared with BMP glucose values, the MARD and median ARD were 18.5% ± 19.1% and 12.2% (5.4, 23.8) during the IV insulin treatment and 22.5% ± 24.7% and 15.1% (6.6, 27.6) after DKA resolution. Conclusion: This is the first report on the use of real-time CGM in adults with DKA. Our study indicates that CGM technology is a reliable tool for hospital use during acute insulin treatment and after the resolution of DKA. Future multicentre randomized studies are needed to determine the benefits of real-time CGM in facilitating diabetes care in hospitalized patients with hyperglycemic crises.
Chronic Benign Tubular Albuminuria From Compound Heterozygous Variants in CUBN: A Case Report
Authors: Pietrobon Adam , Elliott Mark D. 
Published: February 2025

Rationale: Albuminuria is a commonly used parameter for predicting decline in kidney filtration function. Cubilin, encoded by CUBN, is a critical protein involved in protein reabsorption in the proximal tubule. Mutations in CUBN lead to Imerslund-Gräsbeck syndrome (IGS), a disorder characterized by vitamin B12 deficiency (and consequences related to that) with or without albuminuria. Recent evidence suggests that C-terminal variants in CUBN may lead to albuminuria without other features of IGS. Presenting concerns of the patient: Here, we report a case of a 52-year-old male with chronic, albumin-predominant, subnephrotic range proteinuria since his teenage years, but preserved estimated glomerular filtration rate (eGFR). Interventions: Neither angiotensin-converting enzyme (ACE) inhibition nor angiotensin Type II (AT-II) receptor blockade reduced his degree of albuminuria. Diagnosis: Genetic testing identified 3 distinct pathogenic variants in CUBN that were confirmed by segregation analysis to be a compound heterozygous mode of inheritance. All variants were downstream of the intrinsic factor-vitamin B12 binding domain of cubilin. The patient had normal vitamin B12 levels and did not exhibit any features of IGS. Outcomes: Kidney biopsy was not pursued for this patient as diagnostic clarification was achieved by non-invasive genetic testing alone. Novel findings: This case highlights several important lessons. First, not all albuminuria is made equal, and forms of tubular albuminuria can exist without compromising kidney filtration function. Second, identifying genetic forms of tubular albuminuria is key to avoiding ineffective interventions (eg, ACE inhibition, AT-II receptor blockade, sodium-glucose cotransporter-2 [SGLT2] inhibition) and unnecessary invasive procedures (eg, kidney biopsy). Third, the location of CUBN variants dictates phenotypic consequences, with C-terminal variants leading to albuminuria without vitamin B12 deficiency.
Impact of the COVID-19 pandemic on patients affected by endometriosis: A questionnaire-based cross-sectional online survey
Authors: Saponara Stefania , Ciebiera Michal , Vitale Salvatore Giovanni , Agus Mirian , Piselli Andrea , D’Alterio Maurizio Nicola , Feduniw Stepan , Angioni Stefano 
Published: February 2025

Introduction: The COVID-19 pandemic has substantially impacted the management of chronic conditions, particularly endometriosis. This study aims to analyze the effects of the pandemic on the quality of life among women with endometriosis under the care of an academic referral center in Italy. Methods: Conducted from June to October 2020, this observational study utilized an online survey to assess various health dimensions. The participants included women with a confirmed diagnosis of endometriosis whose clinic appointments were cancelled, and new ones were difficult to schedule due to COVID-19 pandemic restrictions. The online questionnaire comprised 117 questions designed to evaluate chronic pelvic pain, quality of life, and psychological impacts using validated scales such as SF-12, HADS, EHP-5, and PSQI. Results: A total of 105 participants completed the online questionnaire. It was found that pandemic-related disruptions in healthcare services exacerbated symptoms of endometriosis, increased pain levels, and heightened psychological distress among participants. Specifically, 23.8% of patients reported increased pain due to delays in medical consultations and treatments caused by the pandemic. Results indicated significant correlations between higher levels of anxiety, depression, and deteriorated physical and mental health. The analysis revealed that pandemic-related stress and disruptions in routine care were significant predictors of worsened symptoms and overall health status in patients with endometriosis. Conclusion: The study underscores the need for integrated care approaches that address both the physical and psychosocial aspects of endometriosis, especially during healthcare crises. Enhanced support and resources are essential to mitigate the impact of such disruptions on chronic disease management and improve the quality of life for those affected.
Respiratory support in patients with Down syndrome: a systematic review
Authors: Ruggeri Paolo , Manti Sara , Li Pomi Alessandra , Lo Bello Federica , Morana Giorgio , Profazio Claudia , Bushra Mina , Esquinas Antonio 
Published: February 2025

BackgroundThe population with Down syndrome (DS) makes up a significant portion of patients using short- and long-term noninvasive ventilation (NIV). However, limited data are available concerning the use and outcomes for patients with DS compared with other populations. We systematically reviewed articles providing indications, benefits, adherence and limits of long-term NIV use in the paediatric and adult population with DS.MethodsA systematic review of the literature for articles published between January 2013 and November 2023 was conducted using a protocol registered atPROSPERO(CRD42023488712).ResultsIn total, 18 studies focusing on the use of noninvasive respiratory support in patients with DS were included in this review. Obstructive sleep apnoea syndrome (OSAS), OSAS post-adenotonsillectomy, hypoventilation and nocturnal hypercapnia were the most common indications for NIV support in patients with DS. However, respiratory anatomical malformation and intellectual disabilities can affect adherence to NIV use. High-flow nasal cannula is an alternative to other noninvasive respiratory support.ConclusionComprehensive and updated consensus compliant with international standards for clinical guidelines is required to significantly improve clinical practice quality, promote evidence-based recommendations and provide tailored interventions in patients with DS.
Role of HNF6 in liver homeostasis and pathophysiology
Authors: Tian Miaomiao , Gao Weizhen , Ma Shujun , Cao Huiling , Zhang Yu , An Fuxiang , Qi Jianni , Yang Zhen 
Published: February 2025

Abstract

Background
Hepatocyte nuclear factor 6 (HNF6), a member of the HNF family, contains single cleft and homologous domains, which form a DNA-binding region that targets the promoter regions of genes that bind to liver-specific genes and regulate their expression. Furthermore, HNF6 is highly expressed as an HNF in the liver.

Main body
HNF6 regulates not only the formation of the liver but also the proliferation and differentiation of hepatocytes. Additionally, HNF6 controls the migration and adhesion of hepatocellular carcinoma cells and plays a significant role in liver metabolism. Its expression is affected by epigenetic modifications such as DNA methylation, post-translational modifications, and microRNAs. Recently, HNF6 was also found to be expressed in tissues, such as the pancreas, intestine, and lungs, where it controls their formation by regulating cell differentiation and influences their pathophysiological processes via various mechanisms.

Conclusion
In this review, we highlight advances in HNF6-related research concerning liver diseases and provide a summary of its potential mechanisms of action as a transcription factor in regulating downstream genes and epigenetic modifications. We also highlight gaps in liver disease research and provide future research directions for the application of HNF6 and its downstream molecules as attractive targets in the treatment of liver diseases.
Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure
Authors: Gimbel Blake A. , Wozniak Jeffrey R. , Mueller Bryon A. , Tuominen Kent A. , Ernst Abigail M. , Anthony Mary E. , de Water Erik ,   the CIFASD, Roediger Donovan J. 
Published: February 2025

Abstract

Background
Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory and decision-making in affected individuals. Here, we evaluate hippocampal anomalies in children with PAE and an unexposed comparison group using advanced MRI methods that characterize hippocampal curvature and thickness.

Methods
Participants, ages 8 to 16 years, included children with PAE (n = 48) and an unexposed comparison group (n = 46) who underwent a dysmorphology exam, neuropsychological assessment, and an MRI scan. Height, weight, head circumference, and dysmorphic facial features were evaluated. Of those with PAE, 4.2% had fetal alcohol syndrome (FAS), 22.9% had partial FAS, and 72.9% had alcohol-related neurodevelopmental disorder. Neuropsychological testing included measures of intelligence and memory functioning. T1-weighted anatomical data were processed with the Hippunfold pipeline, which “unfolds” the complex hippocampal structure onto a template surface and provides measures of thickness and gyrification/curvature at each vertex. Permutation Analysis of Linear Models (PALM) was used to test for group differences (PAE vs. comparison) in hippocampal thickness and gyrification at each vertex and also to assess correlations with cognitive functioning.

Results
There were significant regional differences in thickness and gyrification across bilateral hippocampi, with the PAE group showing substantially thinner tissue and less curvature than the comparison group, especially in CA1 and subiculum regions. For those with PAE, thinner subicular tissue (bilateral) was associated with lower IQ. Also in the PAE group, lower episodic memory performance was associated with thinness in the right hippocampus, especially in the subiculum region. There were no significant regional hippocampal patterns that were associated with cognitive functioning for individuals in the unexposed comparison group.

Conclusions
We used a novel MRI method to evaluate hippocampal structure in children with PAE and an unexposed comparison group. The data suggest that PAE disrupts hippocampal development, impacting both the early-stage folding of the structure and its ultimate thickness. The data also demonstrate that these developmental anomalies have functional consequences in terms of core memory functions as well as global intellectual functioning in children with PAE.
Clinical forms of 5 cases of circumcised penile cancer in immunocompetent subjects in Abidjan (Ivory Coast)
Authors: Yao Evrard Kouame , Yao Abraham Hognou , Yeo Donafologo Daouda , Adebayo Tawakaltu , Tuo Michel , Zouan Freddy Junior , Coulibaly Noel 
Published: February 2025

Abstract

Context
Malignant tumours of the penis are rare. Their incidence varies around the world and increases with age. Treatment is essentially surgical. Surgery may be conservative or radical.
We report the anatomoclinical aspects of 5 cases of penile cancer observed in our department.

Case presentations
A 44-year-old patient with a circumcised penis, diagnosed with a fusosarcoma (a rare type of sarcoma) of the penis. Three patients (ages 61, 59, and 70) were diagnosed with squamous cell carcinoma, the most common type of penile cancer. These patients also had circumcised penises. The last case was a metastatic squamous cell carcinoma of the penis in a 68-year-old patient. All patients were immunocompetent and had a circumcised penis. They refused surgery in any form.

Conclusion
The clinical aspects of penile cancer are polymorphous and misleading. Any bulging or indurated lesions on the penis should be biopsied.
Weak genetic divergence and signals of adaptation obscured by high gene flow in an economically important aquaculture species
Authors: Calla Bernarda , Song Jingwei , Thompson Neil 
Published: February 2025

Abstract

Background
The genetic diversity of a population defines its ability to adapt to episodic and fluctuating environmental changes. For species of agricultural value, available genetic diversity also determines their breeding potential and remains fundamental to the development of practices that maintain health and productivity. In this study, we used whole-genome resequencing to investigate genetic diversity within and between naturalized and captively reared populations of Pacific oysters from the US Pacific coast. The analyses included individuals from preserved samples dating to 1998 and 2004, two contemporary naturalized populations, and one domesticated population.

Results
Despite high overall heterozygosity, there was extremely low but significant genetic divergence between populations, indicative of high gene flow and/or little variability from founding events. The captive population, which was reared for over 25 years was the most genetically distinct population and exhibited reduced nucleotide diversity, attributable to inbreeding. Individuals from populations that were separated both geographically and temporally did not show detectable genetic differences, illustrating the consequences of human intervention in the form translocation of animals between farms, hatcheries and natural settings. Fifty-nine significant F
ST
outlier sites were identified, the majority of which were present in high proportions of the captive population individuals, and which are possibly associated with domestication.

Conclusion
Pacific oysters in the US Pacific coast harbor high genetic heterozygosity which obscures weak population structure. Differences between these Pacific oyster populations could be leveraged for breeding and might be a source of adaptation to new environments.