bluuebunny/crossref_metadata_2025_split huggingface dataset:
FI-CEUS: a solution to improve the diagnostic accuracy in MRI LI-RADS-indeterminate (LR-3/4) FLLs at risk for HCC
Authors: Zeng Qingjing , Xie Sidong , He Xuqi , Guo Yuefei , Wu Yuxuan , He Na , Zhang Lanxia , Yu Xuan , Zheng Rongqin , Li Kai 
Published: January 2024

ObjectiveTo evaluate the diagnostic accuracy of fusion imaging contrast-enhanced ultrasound (FI-CEUS) of magnetic resonance imaging (MRI) LI-RADS-indeterminate (LR-3/4) and conventional ultrasound undetected focal liver lesions (FLLs) in patients at risk for hepatocellular carcinoma (HCC).MethodsBetween February 2020 and July 2021, 71 FLLs in 63 patients were registered for diagnostic performance evaluation respectively for ultrasound-guided thermal ablation evaluation in this retrospective study. Diagnostic performance regarding FLLs was compared between FI-CEUS and contrast-enhanced MRI (CE-MRI).ResultsFor diagnostic performance evaluation, among 71 lesions in 63 patients, the diagnostic efficacy of FI-CEUS with LI-RADS was significantly higher than that of CE-MRI (P &lt; 0.05) in both overall and hierarchical comparison (except for the group with lesion diameter ≥2 cm). For malignant lesions, the proportion of arterial phase hyperenhancement (APHE) and washout on FI-CEUS was higher than that on CE-MRI (P &lt; 0.05).ConclusionFI-CEUS has a high value in the precise qualitative diagnosis of small FLLs (&lt;2 cm) of MRI LI-RADS-indeterminate diagnosis (LR-3/4) that are undetected by conventional ultrasound in patients at risk for HCC and can be a good supplementary CE-MRI diagnostic method for thermal ablation evaluation.
Enhancing dosimetric practices through knowledge-based predictive models: a case study on VMAT prostate irradiation
Authors: Hadj Henni Ahmed , Arhoun Ilias , Boussetta Amine , Daou Walid , Marque Alexandre 
Published: January 2024

IntroductionAcquisition of dosimetric knowledge by radiation therapy planners is a protracted and complex process. This study delves into the impact of empirical predictive models based on the knowledge-based planning (KBP) methodology, aimed at detecting suboptimal results and homogenizing and improving existing practices for prostate cancer. Moreover, the dosimetric effect of implementing these models into routine clinical practice was also assessed.Materials and methodsBased on the KBP method, we analyzed 25 prostate treatment plans performed using VMAT by expert operators, aiming to correlate dose indicators with patient geometry. The DavgCav(Gy), V45GyCav(cc), and V15GyCav(cc) of the peritoneal cavity and the V60Gy(%) and V70Gy(%) of the rectum and bladder were linked to geometric characteristics such as the distance from the planning target volume (PTV) to the organs at risk (OAR), the volume of the OAR, or the overlap between the PTV and the OAR. In the second phase, the KBP was used in routine clinical practice in a prospective cohort of 25 patients and compared with the 41 patient plans calculated before implementing the tool.ResultsUsing linear regression, we identified strong geometric predictive factors for the peritoneal cavity, rectum, and bladder (R2 &gt; 0.8), with an average prescribed dose of 97.8%, covering 95% of the target volume. The use of the model led to a significant dose reduction (Δ) for all evaluated OARs. This trend was most notable for ΔV15GyCav=−171.5 cc (p=0.003). Significant reductions were also obtained in average doses to the rectum and bladder, ΔDavgRect= −2.3 Gy (p=0.040), and ΔDavgVess= −3.3 Gy (p=0.039) respectively. Based on this model, we reduced the number of plans with OAR constraints above the clinical recommendations from 19% to 8%.ConclusionsThe KBP methodology established a robust and personalized predictive model for dose estimation to organs at risk in prostate cancer. Implementing the model resulted in improved sparing of these organs. Notably, it yields a solid foundation for harmonizing dosimetric practices, alerting us to suboptimal results, and improving our knowledge.
The ultrasound-based cardiac output monitoring is a useful tool to define baseline hemodynamic parameters in healthy permanent residents at high altitude: results of a monocentric pilot study
Authors: Viruez-Soto Antonio , Molano-Franco Daniel , Merino-Luna Alfredo , Bairam Aida , Aliaga-Raduán Fernanda , Sanchez Lida , Arias-Reyes Christian , Soliz Jorge 
Published: January 2024

Previous studies on the cardiac data of healthy permanent residents living in high-altitude regions such as Tibet and the Andes have yielded inconsistent findings and significant disparities. These discrepancies can be mainly attributed to the invasive methods conventionally used for parameter evaluation. However, with the introduction of cutting-edge ultrasound technology, there is now an innovative approach to addressing and reconciling these variations. In this pilot study, we employed an ultrasound-based cardiac output monitoring (USCOM) device to evaluate cardiac output and related hemodynamic variables in a group of 20 healthy high-altitude Andean residents (comprising 10 men and 10 women) aged between 26 and 35 years old. The monocentric study was carried out in La Paz, Bolivia, located between at an altitude of 3,600–4,000 m. A total of 60 hemodynamic measurements were evaluated, accounting for three technical replicates per subject. Our results showed strong intrasubject reproducibility and revealed important differences related to both sex and hemodynamic parameters in highlanders compared to individuals residing at sea level. We conclude that USCOM represents a highly reliable technology for performing hemodynamic measurements in high-altitude residents. Our preliminary findings underscore the need for larger studies, encompassing larger sample sizes, specifically tailored to gender considerations, and extendable to broader highland populations. These findings have special significant implications for the management of hemodynamics in intensive care and postoperative settings, warranting further comprehensive research efforts.
Online misinformation can distort witnesses’ memories. Analysis of co-witness discussions using an online version of the MORI-v technique
Authors: Kękuś Magdalena , Szpitalak Malwina , Polczyk Romuald , Barzykowski Krystian 
Published: January 2024

IntroductionThe memory conformity effect occurs when people witness a given incident and then talk to each other about it, and the statement of one person affects the memory account of another person with respect to that incident. The main objectives of this experiment were (1) to examine the effectiveness of a modified version of the MORI-v technique in inducing the memory conformity effect and (2) to investigate how the manner in which participants discuss the observed event influences the magnitude of this effect. In general, the modified online MORI-v technique consists of the following main elements: (1) original material, that is, two versions of a short film which are identical except for certain critical details; for example, in one version, a thief puts on a red cap, but in the other version it is black; (2) the collaborative recognition test, that is, a discussion about the original material which leads to mutual misinformation; and (3) an individual recognition test that checks the effect of the discussion on the memory account of the original material.MethodsA total of 72 participants (36 pairs) aged 18–54 took part in the research. Participants were tested using the online MORI-v technique: They were familiarized with the original material on their computers at home, and then they talked about it via a video communication app and completed an individual recognition test on their computers. Importantly, the discussions were recorded and analyzed in detail after the experimental session.Results and discussionUsing the online MORI-v technique, the effect of memory conformity was demonstrated, that is, in the individual recognition test, the proportion of correct answers to questions about discussed details (related to misinformation) was lower than the proportion of correct answers to questions about non-discussed details. It was also demonstrated that if one participant introduced misinformation during the discussion about a particular item and the other did not question it, the latter’s answer to that item during the individual recognition test was most often incorrect. However, if one participant introduced misinformation during the discussion about an item and the other questioned it, the latter’s answer about that item during the individual recognition test was most often correct.
Integrating health intervention into existing program structure of the neglected tropical diseases: lessons learned from Yobe and Ebonyi states
Authors: Atobatele Sunday , Sampson Sidney , Jimoh Akolade U. , Isiaka Saheed D. , Ayodeji Oluwafisayo , David Joshua C. , Daniel Victor , Dehinbo Oluwafunmilayo 
Published: January 2024

BackgroundNigeria has a national policy on neglected tropical diseases (NTD) which is coordinated by the Federal Ministry of Health and integrated into the health system at all government levels. A network of grassroots mobilizers, named community drug distributors (CDDs), deliver NTD drugs and commodities to rural and hard-to-reach communities throughout Nigeria.MethodsInterviews with state and local government coordinators of Nigerian NTD programs and focus group discussions with CDDs in Yobe and Ebonyi states were conducted to understand the working modalities of NTD programs in Nigeria to identify the potential of leveraging the NTD structure for additional health interventions such as COVID-19 vaccine rollouts. Collected data was coded and managed on NVivo version 12 using content analysis.Results and discussionThe study found that the NTD committee had the following: a structured planning and coordination process, a community mobilization approach for the effective delivery of routine Mass Administration of Medication (MAM) activities. Challenges encountered included little or no incentives for the CDDs, insecurity, transportation and logistics, and lack of equipment and drug commodities. Nigerian NTD health structures have a wide reach, with a presence in all states and local government areas (LGAs), and this has previously been leveraged to deliver commodities and interventions to rural and hard-to-reach communities for non-NTD health programs and could thus be used similarly for COVID-19 vaccination programs. The enablers of integrating health interventions into the NTD structure are increased availability of finances and manpower, while lack of financial incentives and partners’ buy-in were identified as possible. challenges.ConclusionThe study suggests that integrating COVID-19 interventions into the NTD program in Nigeria would be a significant accomplishment, as the existing structure can support future interventions. The study also highlights the efficiency of the NTD program’s modalities and processes, indicating that an organized structural system for public health interventions can. increase the services of existing interventions while allowing for the integration of future interventions.
HPV vaccination in Africa in the COVID-19 era: a cross-sectional survey of healthcare providers’ knowledge, training, and recommendation practices
Authors: Fokom Domgue Joel , Dille Issimouha , Kapambwe Sharon , Yu Robert , Gnangnon Freddy , Chinula Lameck , Murenzi Gad , Mbatani Nomonde , Pande Mala , Sidibe Fatoumata , Kamgno Joseph , Traore Bangaly , Fazazi Hicham El , Diop Mamadou , Tebeu Pierre-Marie , Diomande Mohenou Isidore , Lecuru Fabrice , Adewole Isaac , Plante Marie , Basu Partha , Dangou Jean-Marie , Shete Sanjay 
Published: January 2024

IntroductionAlthough the burden of cervical cancer in Africa is highest, HPV vaccination coverage remains alarmingly low in this region. Providers’ knowledge and recommendation are key drivers of HPV vaccination uptake. Yet, evidence about providers’ knowledge and recommendation practices about the HPV vaccine against a backdrop of emerging vaccine hesitancy fueled by the COVID-19 pandemic is lacking in Africa.MethodsA cross-sectional study was conducted in 2021–2022 among healthcare providers involved in cervical cancer prevention activities in Africa. They were invited to report prior training, the availability of the HPV vaccine in their practice, whether they recommended the HPV vaccine, and, if not, the reasons for not recommending it. Their knowledge about the HPV vaccine was assessed through self-reporting (perceived knowledge) and with three pre-tested knowledge questions (measured knowledge).ResultsOf the 153 providers from 23 African countries who responded to the survey (mean age: 38.5 years, SD: 10.1), 75 (54.0%) were female and 97 (63.4%) were based In countries with national HPV immunization programs. Overall, 57 (43.8%) reported having received prior training on HPV vaccine education/counseling, and 40 (37.4%) indicated that the HPV vaccine was available at the facility where they work. Most respondents (109, 83.2%) reported recommending the HPV vaccine in their practice. Vaccine unavailability (57.1%), lack of effective communication tools and informational material (28.6%), and need for adequate training (28.6%) were the most commonly reported reasons for not recommending the HPV vaccine. While 63 providers (52.9%) reported that their knowledge about HPV vaccination was adequate for their practice, only 9.9% responded correctly to the 3 knowledge questions.ConclusionTo increase HPV vaccination coverage and counter misinformation about this vaccine in Africa, adequate training of providers and culturally appropriate educational materials are needed to improve their knowledge of the HPV vaccine and to facilitate effective communication with their patients and the community.
Assessing soil moisture variability in a vineyard via frequency domain electromagnetic induction data
Authors: De Carlo Lorenzo , Turturro Antonietta Celeste , Caputo Maria Clementina 
Published: January 2024

IntroductionIn agriculture, accurate hydrological information is crucial to infer water requirements for hydrological modeling, as well as for appropriate water management.MethodsTo achieve this purpose, geophysical frequency domain electromagnetic induction (FDEM) measurements are increasingly used for integration with traditional point-scale measurements to provide effective soil moisture estimations over large areas. The conversion of electromagnetic properties to soil moisture requires specific tools that must take into account the spatial variability of the two measurements and the data and model uncertainties. In a vineyard of about 4.5 ha located in Southern Italy, we tested an innovative assessment approach that uses a freeware code licensed from USGS, MoisturEC, to integrate electromagnetic data, collected with a CMD Mini-Explorer electromagnetic sensor, and point-scale soil moisture data.ResultsAbout 30,000 data measurements of apparent electrical conductivity (sa) allowed us to build a 3D inverted electromagnetic model obtained via an inversion process. Soil properties at different depths were inferred from the FDEM model and confirmed through the ground truth sampling.DiscussionThe data analysis tool allowed a more accurate estimation of the moisture distribution of the investigated area by combining the accuracy of the point-scale soil moisture measurements and the spatial coverage of the electrical conductivity (EC) data. The results confirmed the capability of the electromagnetic data to accurately map the moisture content of agricultural soils and, at the same time, the need to employ integrated analysis tools able to update such quantitative estimations in order to optimize soil and water management.
Optimizing tea waste as a sustainable substrate for oyster mushroom (Pleurotus ostreatus) cultivation: a comprehensive study on biological efficiency and nutritional aspect
Authors: Ahmed Raisa , Niloy Md. Asif Hasan Mazumder , Islam Md. Shafiqul , Reza Md. Selim , Yesmin Sabina , Rasul Shahriar Bin , Khandakar Jebunnahar 
Published: January 2024

IntroductionIn Bangladesh, rice straw (RS) and sawdust (SD) substrates have traditionally been used in the production of oyster mushrooms (Pleurotus ostreatus). However, the rising costs of these substrates have led many to look for alternatives.ObjectivesThe present study thus focuses on the potential of waste tea leaves (WTL) for mushroom farming.MethodsWe prepared various substrate mixtures by combining WTL with SD and RS, subsequently evaluating mushroom yield and various quality parameters such as amino acid concentration, mineral content, and biological efficiency.Results and discussionOur investigation revealed that WTL alone is not a suitable substrate for mushroom (Pleurotus ostreatus) growth. However, when combined with SD at a 50% ratio, it significantly boosts mushroom yield and biological efficiency (BE). Conversely, a reduction in yield was noted when WTL was mixed with RS in all tested treatments, although BE surpassed 50%. In summary, incorporating WTL into both substrates proves economically viable from the BE standpoint. According to PCA analysis, the minerals and amino acid content varied based on the different substrate formulations involving WTL blending with both SD and RS at different ratios. Remarkably, mushroom fruiting bodies exhibited lower levels of Na and Fe despite these elements being present in higher concentrations in the growing substrates, suggesting the inability of P. ostreatus to bioaccumulate Na and Fe. Conversely, we observed higher bioaccumulation of Zn and P, even exceeding substrate levels. Importantly, our findings showed that mushrooms cultivated on WTL-based formulations consistently contained elevated Zn levels irrespective of substrate types, indicating that WTL enriched Zn in mushrooms. Additionally, the Fe level increased specifically in RS + WTL-based formulations. All essential and non-essential amino acids were detected, with the highest concentration of histidine, isoleucine, and methionine found in the WTL + SD formulation. Non-essential amino acids (NEAA) like alanine and glutamic acid were more prominent in formulations combining WTL with RS. This study represents the first documented exploration of the impact of WTL on the accumulation of intracellular metabolites including minerals and amino acids, in P. ostreatus.
Comprehensive management of Pindborg tumor in childhood: a case report
Authors: Minnakhmetova D. R. , Topolnitsky O. Z. , Solodovnik O. A. , Tikhonova I. V. 
Published: January 2024

Relevance. The calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a locally aggressive neoplasm characterized by strands and medullary formations of flat and clear cells, often accompanied by spherical calcifications and amyloid-stained hyaline deposits. The Pindborg tumor is rare, representing less than 1% of odontogenic tumors, and typically manifests in individuals aged 20 to 60 years. However, there is a growing incidence of neoplasms of diverse origins in childhood. This article presents a clinical case detailing the comprehensive multi-stage treatment of a pediatric patient with a Pindborg tumor, facilitating complete rehabilitation before reaching adulthood.Clinical case description. This article presents a clinical case detailing the comprehensive management of a patient with a Pindborg tumor. The individual initially sought treatment at the Department of Pediatric Maxillofacial Surgery of A.I. Evdokimov Moscow State Medical and Dental University in 2020, undergoing complete combined treatment until November 2023. Full rehabilitation was successfully achieved by the time of adulthood through a series of four consecutive surgeries, including dental implantation, followed by prosthetics utilizing a non-removable orthopedic structure in the final stage.Conclusion. Initiating comprehensive rehabilitation at an early stage, including dental implantation before reaching adulthood, facilitates complete social adaptation in society and contributes to the patient's harmonious development.
Supporting Tourism Development Through Creative Economy Clusters in Lebak District
Authors: Shofi Elmia Arini 
Published: January 2024

The presence of materials and human resources in the Lebak Regency supports the creation of creative products in this district. However, this potential has not been maximized due to the undeveloped industrial system to support the development of the creative economy. Various causes of the underdeveloped potential and resources of tourism and the creative economy in Lebak Regency are due to the undeveloped industrial structure that supports the development of the creative economy, the unavailability of financing schemes for the creative economy industry players, limited access to marketing for the creative economy and not yet optimal institutional support for the creative economy as well as the large area of Lebak Regency. Creating strategic development is crucial for the future. One form of regional development is through the development of economic clusters. Creative economic cluster is necessary to formulate a development concept and strategy for Lebak Tourism Development. This study uses a SWOT analysis to help formulate a plan or strategy for an organization or a particular practice in a systematic way. The data used in this study are primary data through interviews, questionnaires, field observations, and documentation. Secondary data were obtained through literature studies, government policy documents, government agencies reports, and other media, also both mass media and the Internet. The result formulated 4 strategies for creative economic cluster development, namely (1) Creating creative economy clusters, divided into the north, middle, and south clusters; (2) Creating a tourism village in each cluster based on its creative economy potential; (3) Creating an institutional scheme for developing the creative economy; and (4) Creating project bundling in each cluster.
NGHIÊN CỨU THỰC TRẠNG ỨNG DỤNG CÔNG NGHỆ THÔNG TIN TẠI MỘT SỐ MÔ HÌNH DU LỊCH NÔNG NGHIỆP TẠI THÁI NGUYÊN
Authors: Hải Nguyễn Thế , Thủy Vũ Thị Thanh , Hương Trần Thị Mai , Nguyên Vũ Thị , Lâm Nguyễn Duy 
Published: January 2024

Du lịch nông nghiệp đóng vai trò quan trọng nhằm nâng cao thu nhập của người dân và thúc đẩy phát triển nông thôn bền vững. Nghiên cứu nhằm đánh giá việc sử dụng công nghệ thông tin hiện nay trong quản lý, tiếp thị và bán hàng tại các trang trại và hợp tác xã du lịch nông nghiệp ở tỉnh Thái Nguyên. Nghiên cứu sử dụng phương pháp gồm khảo sát và phỏng vấn trực tiếp, được thực hiện trên tám cơ sở du lịch nông nghiệp ở bốn khu vực của tỉnh Thái Nguyên. Kết quả cho thấy công nghệ thông tin đang được các cơ sở áp dụng, mặc dù có một số hạn chế nhất định. Chỉ có ba trang trại sở hữu các trang web chuyên dụng trong đó một đơn vị cập nhật nội dung một cách nhất quán. Nghiên cứu cho thấy chỉ có 7,08% khách du lịch biết các trang trại nông nghiệp ở tỉnh Thái Nguyên thông qua trang web. Một khuyến nghị từ khách du lịch là các trang trại du lịch nông nghiệp của Thái Nguyên nên thành lập trang mạng xã hội của riêng họ và hợp tác với các trang trại khác để tạo ra trải nghiệm du lịch nông nghiệp toàn diện. Trang web nên cập nhật, cung cấp thông tin về canh tác, giá nông sản, các dịch vụ và bản đồ về các điểm du lịch nông nghiệp của Thái Nguyên.