bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adalimumab Experience in the Management of Hidradenitis Suppurativa Burdened with Rapp-Hodgkin Syndrome
Authors: Murashkin Nikolay N. , Materikin Alexander I. , Epishev Roman V. , Leonova Maria A. , Opryatin Leonid A. , Fedorov Dmitri V. , Ivanov Roman A. , Savelova Alena A. , Katunina Oksana R. , Kulikov Kirill A. , Ufimtseva Anastasiya U. 
Published: November 2023

Background. Rapp-Hodgkin syndrome is a rare genetic disease from the ectodermal dysplasia group. It manifests with damage of ectodermal structures — layer of embrional tissue that provides the development of many organs and tissues in the body, such as: skin, sweat glands, hair, teeth, and nails. Disease symptoms may range from mild to severe and include dental abnormalities, fragile, thin or no hair, abnormal nails, hypohidrosis (due to the reduced number of sweat glands), cleft lips and palate. Hidradenitis suppurativa is a chronic inflammatory disease that predominantly affects apocrine glands areas. This nosology is characterized by painful nodes, abscesses, and fistulas, prone to relapses and leading to scarring.Clinical case description. The authors present a clinical case demonstrating the combination of Rapp-Hodgkin syndrome and severe hidradenitis suppurativa in 17-year-old male patient.Conclusion. The heterogeneous clinical findings of hidradenitis suppurativa and history of rare genetic disease result in patients' admissions to various medical specialists. Thus, it leads to delayed verification of the diagnosis and incorrect treatment methods. As a result, patients have persistent cosmetic skin defects, possible complications of irrational treatment, and decreased quality of life by the time of diagnosis.
Pemphigus Herpetiformis in Childhood: Clinical Case
Authors: Murashkin Nikolay N. , Materikin Alexander I. , Epishev Roman V. , Leonova Maria A. , Opryatin Leonid A. , Fedorov Dmitri V. , Ivanov Roman A. , Savelova Alena A. , Katunina Oksana R. , Kulikov Kirill A. , Yarullin Ilgiz I. 
Published: November 2023

Background. Pemphigus herpetiformis is a rare atypical bullous dermatosis of autoimmune nature. It is characterized by rashes in the form of plaques with papules and vesicles at peripheral areas, or in the form of grouped papules, vesicles or tense bubbles with clinical similarity to During's herpetiformis dermatitis. Pemphigus herpetiformis diagnosis in pediatric practice is difficult due to the similarity of clinical manifestations to bullous dermatoses of other etiology, the rarity of the disease in children, and small number of scientific publications.Clinical case description. Clinical case of pemphigus herpetiformis in a child is described. All necessary diagnostic algorithms for diagnosis and therapeutic tactics for patient management are presented. Dapsone and prednisolone were used as first-line drugs during the patient's treatment. They have shown its efficacy in management of such patients.Conclusion. Differential diagnosis of pemphigus herpetiformis and other bullous dermatoses in children is presented. The results of successful drug treatment are shown.
Association between Comorbidities and COVID-19 Mortality: a Cross-Sectional Study in a Community Health Center in Indonesia
Authors: Sutaip Sutaip , Sutiningsih Dwi , Adi Mateus Sakundarno , Diyana Sutra , Rahayu Siti , Azizah Azzahra Nur , Andalusia Sarigando Banilai Putri , Giyantolin Giyantolin 
Published: November 2023

Objective: To analyze the risk factors for mortality and comorbidity of COVID-19 patients in a public health center work area in Indonesia.Methods: This was a cross-sectional observational analytic quantitative study using secondary data of 820 confirmed COVID-19 cases in Brebes Public Health Center work area during the period of June 2020–December 2021. Univariate and bivariate analyses were used to analyze the obtained data statistically with a p-value of <0.005 considered significant.Results: Of the 820 confirmed COVID-19 patients, 85.1% recovered and 15.0% died. Analysis on the characteristics of these cases showed that 51.2% females and 48.8 % males were included in this study, with 77.6% of them were <60 years old. No history of comorbidities was identified in 92.1% of the cases. In remaining cases with comorbidities, Diabetes Mellitus was recognized as the most prevalent (n=39, 4.8%). Results of the Chi-Square test demonstrated that comorbidity status (p-value = 0.001), place of quarantine (p p=0.000 p>0.05), and diabetes (p=0.000, OR=2.87, 95% CI 19 1.24-0280) were significantly associated with mortality.Conclusion: Comorbidity status, diabetes, and the place quarantine are risk factors for mortality among COVID-19 confirmed cases, especially in Brebes Public Health Center work area. Thus, it is important to increase knowledge about COVID-19 prevention and risks to prevent transmission among those with higher risks for mortality. Further studies on factors related to sustainable supports for COVID-19 patients are also necessary.
Development and characterization of a line with substitution of chromosome 4B of wheat <i>Triticum aestivum</i> L. on chromosome 4H<sup><i>mar</i> </sup> of wild barley <i>Hordeum marinum ssp. gussoneanum (4x)</i>
Authors: Pershina L. A. , Trubacheeva N. V. , Shumny V. K. , Badaeva E. D. 
Published: November 2023

Introgressive hybridization is the main method of broadening the genetic diversity of bread wheat. Wild barley Hordeum marinum ssp. gussoneanum Hudson (2n = 4x = 28) has useful agronomical traits, such as high resistance to stress factors, that could be a potential source of new genes for bread wheat improvement. This study aimed to evaluate the possibility of introgression of H. marinum chromosomes into the genome of bread wheat using an incomplete amphiploid H. marinum ssp. gussoneanum (4x)–T. aestivum (Pyrotrix 28) (2n = 54) carrying the cytoplasm of wild barley. For this purpose, we crossed the line of bread wheat variety Pyrotrix 28 with an incomplete amphiploid, and then selected cytogenetically stable 42­chromosome plants with a high level of fertility in hybrid progeny. Genomic in situ hybridization (GISH) revealed a pair of H. marinum chromosomes in the genome of these plants. C­ banding analysis confirmed that bread wheat chromosome 4B was replaced by wild barley chromosome 4Hmar. SSR markers Xgwm368 and Xgwm6 confirmed the absence of chromosome 4B, and EST markers BAWU808 and BAW112 identified chromosome 4Hmar in the genome of the isolated disomic wheat­barley substitution line. The study of this line showed that the substitution of chromosome 4B with chromosome 4Hmar resulted in a change of some morphological traits. It included intense anthocyanin coleoptile coloration, specific for H. marinum, as well as a lack of purple coloration of the ears in the leaf sheath, specific for Pyrotrix 28. Line 4Hmar(4B) showed increased performance for several traits, including plant height, number of spikes and tillers per plant, spikelet and grain number in the main spike, grain number per plant, but it had decreased values of 1000­grain weight compared to wheat. Cytogenetic stability and fertility of line 4Hmar(4B) indicated a high compensation ability of barley 4Hmar for wheat chromosome 4B and confirmed their homeology.
Recent progress in the measurement of external costs and implications for transport pricing reforms
Authors: Lindberg Gunnar 
Published: November 2023

The external cost of transport has been discussed in the European transport policy since the 60s. However, it was not until the mid-90s that the European Commission decided on a pricing policy for the transport sector. This policy has stimulated a wide array of new research on the external cost of transport. A survey of some of the most recent studies in the area displays a clear picture; the latest studies are clearly focused on the marginal external cost and based on detailed bottom-up methods. The paper summarise the methods used to estimate some of the components of the marginal cost of transport - marginal infrastructure cost, congestion and scarcity cost, accident and environmental cost. The survey displays the huge variation in the estimates that follows from the use of more detailed databases. While this may be perceived as a problem for blunt pricing policies the paper suggests that it highlights the need for a more refined pricing policy in the transport sector.
EST Case Studies and Perspectives in Japan
Authors: Moriguchi YuichiE , Kato Hirokazu 
Published: November 2023

Results and discussion of the Environmentally Sustainable Transport (EST) Case Study for Japan are introduced within this paper. According to procedures defined in the EST project by the OECD, the targets for a major reduction of environmental load within the transport sector are defined to be CO2, NOx, PM, and VOC. Three scenarios to accomplish these reduction targets, with respect to these environmental loads are detailed: a technooptimistic scenario (EST1), a transport demand management scenario (EST2), and a composite scenario (EST3). All of the scenarios are examined and compared to the business-as-usual (BAU) scenario. Policy instruments to realize these scenarios and their socioeconomic impacts were, to date, not assessed within the study. Utilizing a “back casting” methodology, expected changes in technology and transport behavior in order to meet an ultimate target of emissions reduction were examined by each of the scenarios. The objective areas consisted of a national study, encompassing the whole of Japan, and a regional (Aichi prefecture) study.

The forecasts indicate that CO2 emissions increase by about 10% in Japan but are almost stable in Aichi prefecture. NOx and HC emissions in 2030 are about half, and PM emissions around one quarter of those in 1990 in Aichi prefecture. The results of the back casting indicate that CO2 and NOx reduction targets have severely restrictive conditions. The achievement of targets utilizing only EST1 and EST2 is totally unfeasible. Even in the combined EST3 scenario, and in light of current trends requirements must include strong recommendations for change such as the significant wide spread use of fuel cell vehicles and the reduction of freight transport demands, and hence the scenario still needs to be discussed further.
A Gradient Projection Algorithm for Side-constrained Traffic Assignment
Authors: Prashker Joseph N. , Toledo Tomer 
Published: November 2023

Standard static traffic assignment models do not take into account the direct effects of capacities on network flows. Separable link performance functions cannot represent bottleneck and intersection delays, and thus might load links with traffic volumes, which far exceed their capacity. This work focuses on the side-constrained traffic assignment problem (SCTAP), which incorporates explicit capacity constraints into the traffic assignment framework to create a model that deals with capacities and queues. Assigned volumes are bounded by capacities, and queues are formed when capacity is reached. Delay values at these queues are closely related to Lagrange multipliers values, which are readily found in the solution. The equilibrium state is defined by total path travel times, which combine link travel times and delays at bottlenecks and intersections for which explicit capacity constraints have been introduced.

This paper presents a new solution procedure for the SCTAP based on the inner penalty function method combined with a path-based adaptation of the gradient projection algorithm. This procedure finds a solution at the path level as well as at the link level. All intermediate solutions produced by the algorithm are strictly feasible. The procedure used to ensure that side-constraints are not violated is efficient since it is only performed on constrained links that belong to the shortest path.
Choice Set Generation for Multi-modal Travel Analysis
Authors: Fiorenzo-Catalano Stella , van Nes Rob , Bovy Piet H.L. 
Published: November 2023

Multi-modal trips are a common travel phenomenon, which are expected to become more important in the future because of their expected contribution to sustainable urban transportation. However, multiple different types of travel choices, such as transport service types, travel modes, and transfer locations, are involved in a multi-modal trip, making it difficult to model multi-modal traveling. We present a method that generates choice sets of multi-modal routes using a supernetwork, which might be used for prediction purposes. This method considers stochasticity in the perception of the network attributes as well as in the preferences for the different trip components. The primary objective of the paper is to analyze the comparison of generated route sets and observed route sets. Three options for generating route sets have been studied, i.e.: variation in the network attributes only, variation in traveler preferences only, and the combination of both. The latter case proved to yield the best match with observed route sets. Furthermore, the analysis shows that variation in travelers’ preferences is more important than variation in network attributes. Recommendations for further improvement of the choice set generation method are included. The analysis revealed insights into the possibilities of generating realistic multi-modal route sets and it is proved that the randomization approach is feasible providing good coverage of the observed routes. By far the best results are obtained by randomizing both network attributes and variation in traveler preferences.
A Critical Review of the Standards and Design Processes for Motorway Diverges in the UK
Authors: Wall G.T. , Hounsell N.B. 
Published: November 2023

This paper contains a critical review of design standards for motorway diverges in the UK over the last 40 years. These standards have been progressively updated at regular intervals and their evolving nature has been assessed. Most changes have been minor as a result of changes to traffic flow, driver behaviour or vehicle performance. A brief comparison has also been made between standards for diverges in the UK and those in other selected EU countries. This paper particularly focuses on the diverging flow-region diagram contained in the latest Government Standard TD22/92 ‘The Layout of Grade-Separated Junctions’. This diagram is used by traffic engineers as a tool in order to select the most appropriate diverge layout for a particular site. The historical background leading to its derivation is reviewed along with a discussion of comments made by five practicing traffic engineers as to its effectiveness and usage. These comments have been used along with other analysis to make recommendations as to how the diagram should be interpreted and how it could be improved.
Book Review
Authors: Berechman Joseph 
Published: November 2023

This book is a compilation of papers presented in a seminar on “Policy and project evaluation: context, theory and methods”, held in Brussels in 2000 and which was organized by the Interdisciplinary Center for Comparative Research in Social Sciences with support from the European Commission. In addition to the introductory chapter, written by two of the editors, the book contains 7 papers. These are roughly divided between 3 papers, which describe the “European scene”, and 4 papers, which review approaches and methods of transport evaluation. Needless to say, in a book of this nature some overlap between chapters is largely unavoidable. In general, however, I find the book to be well organized and the chapters quite informative and well written.
Decoupling Transport from Economic Growth
Authors: Tight M.R. , Delle Site Paolo , Meyer-Rühle Olaf 
Published: November 2023

This paper reports on a research project that aimed to identify and assess measures which could be used to reduce travel demand while maintaining economic growth and enhancing environmental quality. The research methodology involved a detailed review of past research; contact with over 600 experts from around Europe and elsewhere for ideas on potential measures; detailed questionnaires from over 100 of these experts; and a series of three panel sessions held in different parts of Europe, each of which involved around 16 experts debating the merits of different measures and identifying case study evidence of their effectiveness. The end result was a shortlist of 13 measures, indicative of broad types, which are considered to be effective, and an indication of their effectiveness if applied across the European Union.

Seven illustrative measures are discussed which stand out from the results as having proven potential (though not necessarily at a European scale) to influence transport intensity and/or unit environmental load whilst not having large detrimental effects on GDP. These are the areas where it is felt that European transport policy could most usefully be focussed in terms of decoupling of transport demand and economic growth.
A Novel Communication and Radar System for Underground Railway Applications
Authors: Lienard Martine , Degauque Pierre , Laly Pierre 
Published: November 2023

A system allowing data to be exchanged between two successive trains in a tunnel, while simultaneously measuring the distance between them, would help to optimize train traffic in very long tunnels, without lowering safety standards. A study including both theoretical and experimental phases was conducted to design and optimize such a system and focused on the Channel Tunnel, between France and England, where a minimum range of 5 km is necessary for operational use. A prototype, operating at 2.45 GHz and based on this new concept, produced successful results. Given that this technique would also be useful in any underground rail system, particularly those that are automated, the prototype was also tested on subway lines, in Lille and Paris.
European Perspectives:
Authors: Stead Dominic 
Published: November 2023

Urban transport systems are critical elements of the urban fabric. They ensure that people have access to goods, services, employment and recreation opportunities, that freight circulates efficiently and they enable local economies to flourish. However, if the high density of buildings is the first defining characteristic of towns and cities, then high volumes of traffic is now the second. Traffic has significant impacts on the environment and on the health of urban citizens, as well as on the overall quality of life in towns. Rising congestion levels are hampering mobility, with increasing costs for the economy (0.5% of Community GDP for road traffic congestion, rising to 1% by 2010).
Book Review
Authors: Wegman Fred 
Published: November 2023

What effect does a road safety measure have on the number of casualties, what are the costs, and are there any side effects to be mentioned? The Norwegian researchers Rune Elvik and Truls Vaa have tried to answer these elementary questions. They have done this in a handbook of more than 1000 pages. The authors themselves have admitted that "handbook" is not really the right name, because in a handbook you expect to find instructions or advices about how to draw up and implement the best road safety measures. The authors admit that an encyclopaedia or catalogue is a more accurate name.
Effect of salinity on serum steroid levels and gonad development in common carp (Cyprinus carpio Linnaeus, 1758) reared in inland saline water
Authors: Iffat Jahan , Tiwari V. K. , Sambid Swain 
Published: November 2023

The effect of salinity on serum steroid levels and gonadal development were investigated in the common carp Cyprinus carpio Linnaeus, 1758. Fishes were stocked in eight rectangular earthen ponds at four different salinities of 0, 5, 10 and 15 ppt. Changes in serum concentration of cortisol, 17 β – Estradiol, progesterone; 17α, 20β dihydroxyprogesterone and androgens were investigated. Gonadal histology in male and female C. carpio was studied at different stages of gonadal maturity till ovulation or spermiation. Serum steroid analysis showed significantly high levels (p<0.05) in fish groups reared at 0 and 5 ppt compared to 10 and 15 ppt. Significantly higher cortisol levels were found during ovulation or spermiation at 10 and 15ppt. In the present study, C. carpio was found to mature faster at 5 ppt as compared to higher salinities of 10 and 15 ppt, in inland saline water.
Keywords: Aquaculture, Cyprinus carpio, Maturation, Salinity, Steroid hormones
Mantle Metasomatism and REE Enrichment in the Genetic Source of the Dalucao Carbonatite Complex (Sichuan, China): Insights from Elemental Geochemistry and In-Situ Sr Isotopes of Two Calcite Types
Authors: Shu Xiaochao , Meng Fanwei , Tao Rui , Wang Kun 
Published: November 2023

Abstract
Carbonatites possess the highest rare earth element (REE) concentrations among all magmatic rocks, yet the mechanisms governing the enrichment of REEs in carbonatites remain enigmatic. Carbonatite-hosted calcites provide crucial mineralogical and geochemical insights into addressing this matter. In this study, we present a dataset comprising major and trace elemental geochemistry, as well as in-situ Sr isotopic data, for two types of calcites from the Dalucao carbonatite complex in Sichuan Province, China. Our primary objective is to shed light on the origin of fertile carbonatites. These calcites are believed to have originated at different stages of carbonatitic evolution. Type I calcites, characterized by a euhedral granular texture and a homogeneous surface, crystallized at the early stage of carbonatite magmatism. In contrast, type II calcites, closely associated with bastnäsite in a paragenesis, formed within a fluid setting of hydrothermal overprinting. Both calcite types exhibit highly radiogenic (87Sr/86Sr)i ratios, ranging from 0.7059 to 0.7060 for type I calcites and 0.7059 to 0.7068 for type II calcites. The high Sr concentrations (3646–7315 µg/g for type I calcites and 6566–13,427 µg/g for type II calcites) and uniform Pb isotopic compositions (206Pb/204Pb ratios of 18.23–18.27) in the Dalucao calcites refute the hypothesis of crustal assimilation as their genetic source. Instead, the radiogenic Sr isotopic compositions suggest that subducted marine sediments have contaminated the lithospheric mantle that generated the carbonatitic magma. Mineralogical evidence indicating the presence of abundant silicate minerals in the Dalucao carbonatites, combined with a compilation of published C-O isotopic data, suggests that these carbonatites may have resulted from low-degree partial melting (melting proportion &lt;1%) of a metasomatized lithospheric mantle. Finally, we propose a comprehensive model for REE enrichment in the Dalucao carbonatite complex and explore the significance of tectonism in the genesis of fertile carbonatites.
Dynamic response of Two-DOF homogeneous dynamical systems
Authors: Mohan Govind , Pandey Umesh Kumar 
Published: November 2023

Abstract

When structures are subjected to dynamic types of loads, cracks are fairly consistent. Under dynamic loads, such structures exhibit nonlinear and inelastic behaviour. If a suitable load history is taken into account, such structures are assumed to have been fully cracked in flexural tension on top as well as at bottom. This assumption implies that no new cracks will appear when the beam is loaded in the future. As the future loads are assumed not to exceed working load levels, the member behaves as nonlinear-elastic systems. A new class of nonlinear homogeneous dynamical systems has been used to anticipate the dynamical behaviour of the two-DOF cracked concrete beam. This class of systems has a fully nonlinear vibration response that is dependent on the loading details and system parameters of the defined two-DOF dynamical system. In the same way as other nonlinear dynamical systems, concrete beam response has been demonstrated to be extremely sensitive to initial conditions as well as the system parameters and display sub-harmonics. The empirical validity and practical applicability of the proposed theory have been investigated.