bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foraging behavior of Highland cattle in silvopastoral systems in the Alps
Authors: Nota Ginevra , Svensk Mia , Barberis Davide , Frund David , Pagani Rebecca , Pittarello Marco , Probo Massimiliano , Ravetto Enri Simone , Lonati Michele , Lombardi Giampiero 
Published: December 2023

AbstractTrees and shrubs expanded in the last decades in European mountains due to land abandonment and the decrease in grazing pressure, and are expected to further spread also due to climate change. As a consequence of low forage quality and topographic constraints, the management of mountain environments dominated by woody vegetation with livestock is often challenging. Silvopastoral systems based on cattle hardy breeds able to forage on woody plants, such as Highland cattle, could be a suitable option for the management and restoration of such environments. In this study, we used direct observations to explore the foraging behavior of Highland cattle in four study areas across the western Alps. In particular, we assessed: (1) cattle diet composition, (2) the selection for more than 30 tree and shrub species, and (3) the relationships between species consumption and their abundance in the environment. Highland cattle fed on a mixture of both woody and herbaceous species, including between 15 and 46% of woody plants in the diet. Some trees (e.g., Celtis australis, Fraxinus spp., and Populus tremula) and shrubs (e.g., Frangula alnus, Rhamnus spp., and Rubus idaeus) were positively selected by cattle, thus they could be an important forage supplement to their diet. Moreover, the results highlighted that relative species consumption generally increased with increasing species abundance in the environment, suggesting that this cattle breed could be suitable to control shrub expansion in highly encroached areas. The outcomes of this study can support the development of targeted silvopastoral systems in the Alps.
The impact of public climate change concern on sustainable product consumption: a case study of new energy vehicles in China
Authors: Han Shuihua , Mo Yudi , Liu Zhenyuan , Lei Cheng , Ye Zhen 
Published: December 2023

AbstractWith global climate change problems becoming increasingly serious, sustainable consumption has become an inevitable trend. In this paper, we take the Chinese new energy vehicle market as an example and research the relationship between the public climate change concern and sustainable product consumption behaviour, while considering the time decay effect of public concern. We collect authoritative secondary data on climate change Baidu search index and the monthly sales of new energy vehicle brands and use panel data to test the hypotheses empirically. The result shows that there is a significant positive effect of public climate change concern on new energy vehicle consumption behaviour. This effect is also present when the time decay effect is considered. The result shows that public new energy vehicle concern has a significant negative effect on new energy vehicle consumption behaviour. The findings provide theoretical support for government policymakers and corporate managers to promote the adoption and diffusion of sustainable products.
In vitro assessment of antibacterial and antiviral activity of three copper products after 200 rounds of simulated use
Authors: Charles Marthe K. , Williams Teresa C. , Nakhaie Davood , Woznow Tracey , Velapatino Billie , Lorenzo-Leal Ana C. , Bach Horacio , Bryce Elizabeth A. , Asselin Edouard 
Published: December 2023

AbstractCopper has well-documented antibacterial effects but few have evaluated it after prolonged use and against bacteria and viruses. Coupons from three copper formulations (solid, thermal coating, and decal applications) and carbon steel controls were subjected to 200 rounds simulated cleaning using a Wiperator™ and either an accelerated hydrogen peroxide, quaternary ammonium, or artificial sweat products. Antibacterial activity against S. aureus and P. aeruginosa was then evaluated using a modified Environmental Protection Agency protocol. Antiviral activity against coronavirus (229E) and norovirus (MNV-1) surrogates was assessed using the TCID50 method. Results were compared to untreated control coupons. One hour after inoculation, S. aureus exhibited a difference in log kill of 1.16 to 4.87 and P. aeruginosa a log kill difference of 3.39–5.23 (dependent upon copper product and disinfectant) compared to carbon steel. MNV-1 demonstrated an 87–99% reduction on each copper surfaces at 1 h and 99% reduction at 2 h compared to carbon steel. Similarly, coronavirus 229E exhibited a 97–99% reduction after 1 h and 90–99% after 2 h. Simulated use with artificial sweat did not hinder the antiviral nor the antibacterial activity of Cu surfaces. Self-sanitizing copper surfaces maintained antibacterial and antiviral activity after 200 rounds of simulated cleaning.
Graphical abstract
The Human GP130 Cytokine Receptor and Its Expression—an Atlas and Functional Taxonomy of Genetic Variants
Authors: Chen Yin-Huai , van Zon Sarah , Adams Alex , Schmidt-Arras Dirk , Laurence Arian D. J. , Uhlig Holm H. 
Published: December 2023

AbstractGenetic variants in IL6ST encoding the shared cytokine receptor for the IL-6 cytokine family GP130 have been associated with a diverse number of clinical phenotypes and disorders. We provide a molecular classification for 59 reported rare IL6ST pathogenic or likely pathogenic variants and additional polymorphisms. Based on loss- or gain-of-function, cytokine selectivity, mono- and biallelic associations, and variable cellular mosaicism, we grade six classes of IL6ST variants and explore the potential for additional variants. We classify variants according to the American College of Medical Genetics and Genomics criteria. Loss-of-function variants with (i) biallelic complete loss of GP130 function that presents with extended Stüve-Wiedemann Syndrome; (ii) autosomal recessive hyper-IgE syndrome (HIES) caused by biallelic; and (iii) autosomal dominant HIES caused by monoallelic IL6ST variants both causing selective IL-6 and IL-11 cytokine loss-of-function defects; (iv) a biallelic cytokine-specific variant that exclusively impairs IL-11 signaling, associated with craniosynostosis and tooth abnormalities; (v) somatic monoallelic mosaic constitutively active gain-of-function variants in hepatocytes that present with inflammatory hepatocellular adenoma; and (vi) mosaic constitutively active gain-of-function variants in hematopoietic and non-hematopoietic cells that are associated with an immune dysregulation syndrome. In addition to Mendelian IL6ST coding variants, there are common non-coding cis-acting variants that modify gene expression, which are associated with an increased risk of complex immune-mediated disorders and trans-acting variants that affect GP130 protein function. Our taxonomy highlights IL6ST as a gene with particularly strong functional and phenotypic diversity due to the combinatorial biology of the IL-6 cytokine family and predicts additional genotype-phenotype associations.
Anadromous trout from opposite sides of the globe: biology, ocean ecology, and management of anadromous brown and cutthroat trout
Authors: Losee James P. , Palm Daniel , Claiborne Andrew , Madel Gabe , Persson Lo , Quinn Thomas P. , Brodin Tomas , Hellström Gustav 
Published: December 2023

AbstractAnadromous brown trout (Salmo trutta) in the northeastern Atlantic Ocean, and coastal cutthroat trout (Oncorhynchus clarkii clarkii) in the northeastern Pacific Ocean, are analogs in many ways. Both species display similar patterns of complex life histories and behavioral flexibility, are iteroparous and facultatively anadromous and occupy nearshore coastal marine habitats where numerous populations often mix. These characteristics create specific challenges for management and conservation that have been complicated by inadequate scientific attention in some areas. Both species are declining across their native range, and their ecology make them particularly vulnerable to habitat destruction, fishing, and climate change. Here, we review the available literature to compare the biology, ocean ecology, and management practices of these two species. We highlight ecological similarities and differences between the species and identify current knowledge gaps suggesting future research needs and management actions. Using a comparative approach, the review aims to promote and facilitate knowledge exchange between anadromous trout research communities from opposite sides of the globe to improve management and conservation of these species and stimulate the production of management plans specific to anadromous trout.
Seeds in rocky soil: the interactive role of entrepreneurial legacy and bridging in family firms’ organizational ambidexterity
Authors: Wilmes Rolf , Brändle Leif , Kuckertz Andreas 
Published: December 2023

AbstractExisting research on family firms emphasizes the importance of entrepreneurship across generations but leaves the role of entrepreneurial transmissions between predecessors and successors relatively unexplore . Building on the concept of entrepreneurial legacy, we ask how interactions of entrepreneurial mindsets and resources influence organizational ambidexterity in family firms. The study’s central argument (and metaphor) is that organizational ambidexterity thrives in multigenerational family firms if successors’ awareness of the family’s entrepreneurial legacy (the right seed) interacts with predecessors’ provision of entrepreneurial resources during succession (the fertile soil), also known as entrepreneurial bridging. We analyze a unique sample of successors from 296 multigenerational family firms in the agricultural sector. Our results point to the relevance of entrepreneurial resources in predecessor-successor collaborations to unlock the family firm’s ability to balance entrepreneurial exploration and exploitation.
Morphological and molecular evidence for natural hybridization between Sorbus pohuashanensis and S. discolor (Rosaceae)
Authors: Wu Yuxia , Yu Xuedan , Tang Wei , Yang Wenhua , Fu Qidi , Zheng Yongqi , Zhang Chuanhong 
Published: December 2023

AbstractIn overlapping distribution areas of Sorbus pohuashanensis and S. discolor in North China (Mount Tuoliang, Mount Xiling and Mount Baihua), Sorbus individuals were found with pink fruit, which have never been recorded for the flora of China. Fourteen morphological characters combined with four chloroplast DNA markers and internal transcribed spacer (ITS) were used to analyze the origin of the Sorbus individuals with pink fruits and their relationship to S. pohuashanensis and S. discolor. PCA, SDA and one-way (taxon) ANOVA of morphological characters provided convincing evidence of the hybrid origin of Sorbus individuals with pink fruits based on a novel morphological character and many intermediate characters. Haplotype analysis based on four cpDNA markers showed that either S. pohuashanensis or S. discolor were maternal parents of Sorbus individuals with pink fruits. Incongruence of the position of Sorbus individuals with pink fruits between cpDNA and ITS in cluster trees supported by DNA sequence comparative analysis, implying former hybridization events between S. pohuashanensis and S. discolor. Multiple hybridization events between S. pohuashanensis and S. discolor might have contributed to the generation of Sorbus individuals with pink fruits. This study has provided insights into hybridization between species of the same genus in sympatric areas, which is of great significance for the study of interspecific hybridization.
On the existence of uncountable Hopfian and co-Hopfian abelian groups
Authors: Paolini Gianluca , Shelah Saharon 
Published: December 2023

AbstractWe deal with the problem of existence of uncountable co-Hopfian abelian groups and (absolute) Hopfian abelian groups. Firstly, we prove that there are no co-Hopfian reduced abelian groups G of size < p with infinite Torp(G), and that in particular there are no infinite reduced abelian p-groups of size < p. Secondly, we prove that if $${2^{{\aleph _0}}} < \lambda < {\lambda ^{{\aleph _0}}}$$

2

ℵ
0

<
λ
<

λ

ℵ
0

, and G is abelian of size λ, then G is not co-Hopfian. Finally, we prove that for every cardinal λ there is a torsion-free abelian group G of size λ which is absolutely Hopfian, i.e., G is Hopfian and G remains Hopfian in every forcing extension of the universe.
Categories of abelian varieties over finite fields II: Abelian varieties over $${\mathbb{F}_q}$$ and Morita equivalence
Authors: Centeleghe Tommaso Giorgio , Stix Jakob 
Published: December 2023

AbstractThe category of abelian varieties over $${\mathbb{F}_q}$$

F
q

is shown to be anti-equivalent to a category of ℤ-lattices that are modules for a non-commutative pro-ring of endomorphisms of a suitably chosen direct system of abelian varieties over $${\mathbb{F}_q}$$

F
q

. On full subcategories cut out by a finite set w of conjugacy classes of Weil q-numbers, the anti-equivalence is represented by what we call w-locally projective abelian varieties.
Lnc-HIBADH-4 Regulates Autophagy-Lysosome Pathway in Amyotrophic Lateral Sclerosis by Targeting Cathepsin D
Authors: Huang Jingxuan , Yu Yujiao , Pang Dejiang , Li Chunyu , Wei Qianqian , Cheng Yangfan , Cui Yiyuan , Ou Ruwei , Shang Huifang 
Published: December 2023

AbstractAmyotrophic lateral sclerosis (ALS) is the most prevalent and lethal class of severe motor neuron diseases (MND) with no efficacious treatment. The pathogenic mechanisms underlying ALS remain unclear. Nearly 90% of patients exhibit sporadic onset (sALS). Therefore, elucidating the pathophysiology of ALS is imperative. Long non-coding RNA (lncRNA) is a large class of non-coding RNAs that regulate transcription, translation, and post-translational processes. LncRNAs contribute to the pathogenesis of diverse neurodegenerative disorders and hold promise as targets for interference in the realm of neurodegeneration. However, the mechanisms of which lncRNAs are involved in ALS have not been thoroughly investigated. We identified and validated a downregulated lncRNA, lnc-HIBADH-4, in ALS which correlated with disease severity and overall survival. Lnc-HIBADH-4 acted as a “molecular sponge” regulating lysosomal function through the lnc-HIBADH-4/miR-326/CTSD pathway, thereby impacting autophagy-lysosome dynamics and the levels of cell proliferation and apoptosis. Therefore, this study discovered and revealed the role of lnc-HIBADH-4 in the pathogenesis of ALS. With further research, lnc-HIBADH-4 is expected to provide a new biomarker in the diagnosis and treatment of ALS.
Sputtered Stainless Steel on Silicon Photoanode for Stable Seawater Splitting in Photoelectrochemical Flow Cell
Authors: Zhao Shixuan , Liu Bin , Zhang Gong , Wang Qingzhen , Cai Yuan , Tong Yuting , Wang Shujie , Zhang Peng , Wang Tuo , Gong Jinlong 
Published: December 2023

AbstractPhotoelectrochemical (PEC) seawater splitting is a promising method for the direct utilization of solar energy and abundant seawater resources for hydrogen production. Photoelectrodes are susceptible to various ions in seawater and complicated competitive reactions, resulting in the failure of photoelectrodes. This paper proposes the design and fabrication of different sputtered stainless steel (SS) films deposited on silicon photoanodes, completely isolating the electrolytes and semiconductor substrate. Upon coupling with the PEC flow cell, the back-illuminated photoanode coated with 316 SS cocatalyst achieves stable operation for 70 h in natural seawater with a highly alkaline KOH (30 wt.%, 7.64 mol/L) electrolyte due to the remarkable protection effect of the substrate from stainless steel, while the PEC seawater splitting system achieves a record hydrogen production rate of 600 μmol/(h·cm2). An appropriate Ni/Fe ratio in the SS ensures remarkable oxygen evolution activity, while chromic oxide ensures the effective anticorrosion effect by adjusting the microenvironment of the photoanodes. Moreover, fabricating PEC flow cells with photoanodes coated with SS cocatalysts are a viable strategy for PEC seawater splitting.
A new lymphography protocol and interpretation principles based on functional lymphatic anatomy in lower limb lymphedema
Authors: Shinaoka Akira 
Published: December 2023

AbstractIndirect lymphatic system imaging is essential for diagnosing lymphatic diseases. The basic methodology involves intradermal or subcutaneous injection of a contrast agent into the surrounding lymphatic capillary, and the flow of the contrast agent is identified using a detector. Many contrast agents that use near-infrared dye, including indocyanine green (ICG) fluorescent lymphography, are available. ICG is rapidly spreading as a convenient and safe lymphedema diagnostic method, because it does not involve radiation exposure, and the imaging equipment is more compact than other devices. The lymphatic system is a semi-open circulatory system with numerous lymphatic capillaries acting as blind ends. Anatomical information on the injection site and observation of specific lymphatic vessels and nodes is important. However, this anatomical information is lacking. Recent reports suggest that ICG fluorescent lymphography can be applied to cadavers in the same manner as living bodies. Furthermore, these reports have demonstrated the functional aspects of the capillary lymph vessel networks as well as their relationship with lymphatic vessels and lymph nodes. This review article describes the historical progression from the old to the new functional lymphatic anatomy and introduces a new functional lymphography technique for the lower limbs.
Local Administrations of Iron Oxide Nanoparticles in the Prefrontal Cortex and Caudate Putamen of Rats Do Not Compromise Working Memory and Motor Activity
Authors: Irrsack Ellen , Aydin Sidar , Bleckmann Katja , Schuller Julia , Dringen Ralf , Koch Michael 
Published: December 2023

AbstractIron oxide nanoparticles (IONPs) have come into focus for their use in medical applications although possible health risks for humans, especially in terms of brain functions, have not yet been fully clarified. The present study investigates the effects of IONPs on neurobehavioural functions in rats. For this purpose, we infused dimercaptosuccinic acid-coated IONPs into the medial prefrontal cortex (mPFC) and caudate putamen (CPu). Saline (VEH) and ferric ammonium citrate (FAC) were administered as controls. One- and 4-week post-surgery mPFC-infused animals were tested for their working memory performance in the delayed alternation T-maze task and in the open field (OF) for motor activity, and CPu-infused rats were tested for their motor activity in the OF. After completion of the experiments, the brains were examined histologically and immunohistochemically. We did not observe any behavioural or structural abnormalities in the rats after administration of IONPs in the mPFC and the CPu. In contrast, administration of FAC into the CPu resulted in decreased motor activity and increased the number of microglia in the mPFC. Perls’ Prussian blue staining revealed that FAC- and IONP-treated rats had more iron-containing ramified cells than VEH-treated rats, indicating iron uptake by microglia. Our results demonstrate that local infusions of IONPs into selected brain regions have no adverse impact on locomotor behaviour and working memory.
Fatal pulmonary hemorrhage, pneumothorax and skin necrosis caused by IRIS to an Aspergillus flavus infection in a young patient with metamizole associated agranulocytosis
Authors: Banz Micha , Stallmach Andreas , Gaßler Nikolaus , Schulze P. Christian , Fritzenwanger Michael , Cornely Oliver , Kurzai Oliver , Pletz Mathias W. 
Published: December 2023

AbstractWe report the case of a young female with steroid-dependent ulcerative colitis (UC) who developed a complex systemic infection with Aspergillus flavus. This occurred following a UC relapse while vacationing in the Middle East, leading to extended use of metamizole and subsequent agranulocytosis. On her return to Germany, she was hospitalized for neutropenic sepsis and later transferred to our hospital due to persistent cytopenia and suspected Hemophagocytic Lymphohistiocytosis (HLH). Despite initial stabilization with targeted treatment for pulmonary Aspergillus flavus infection, her condition rapidly deteriorated following the onset of an Immune Reconstitution Inflammatory Syndrome (IRIS), which manifested as skin necrosis and pneumothorax after the replenishment of neutrophil granulocytes. The patient eventually died from an unmanageable pulmonary hemorrhage. Microscopy of skin necroses showed a massive presence of Aspergillus flavus, but tissue culture remained negative, suggesting effective antifungal treatment yet delayed phagocytosis due to agranulocytosis. This case underscores the need to consider IRIS in immunosuppressed patients who worsen despite aggressive and appropriately targeted treatment, highlighting its potential beyond the commonly recognized context in HIV-positive patients.
Innovating CBT and Answering New Questions: the Role of Internet-Delivered CBT
Authors: Andersson Gerhard 
Published: December 2023

AbstractInternet-delivered cognitive behavior therapy (ICBT) was developed in the late 1990s, and since then, a large number of studies have been conducted. Many programs have been developed and sometimes implemented, and ICBT has become a major way to investigate and innovate CBT including important questions regarding mechanisms and moderating factors. The aim of this narrative review was to comment on the treatment format, the evidence behind ICBT, innovations, and finally challenges. ICBT has been developed and tested for a range of conditions including both psychiatric and somatic health problems and also transdiagnostic problems like loneliness and poor self-esteem. Meta-analytic reviews suggest that guided ICBT can be as effective as face-to-face CBT and by using individual patient data meta-analytic methods (IPDMA), it is now possible have better power for the search of moderators. There are also several reports of how well ICBT works in regular clinical settings, mostly replicating the results reported in efficacy studies. Cost-effectiveness has also been documented as well as studies using qualitative methodology to document client and clinician experiences. In terms of innovation, there are now studies on problems for which there is limited previous face-to-face research, and one major advancement is the use of factorial design trials in which more than one independent variable is tested. Finally, ICBT has the potential to be useful in times of crisis, with the COVID-19 pandemic being one recent example. Future challenges include use of artificial intelligence in both treatment development and possibly treatment delivery. Another urgent priority is to reach less favored parts of the world as most studies and programs have been tested and implemented in Western countries. In conclusion, ICBT is now an established as a way to develop, test, and deliver CBT.