bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of the Acute Phase Inflammatory Marker — C-Reactive Protein in Patients with Chronic Bronchial Affections
Authors: Shevchuk–­Budz U.I. 
Published: December 2023

Chronic lung diseases, particularly those affecting the bronchial tree, are a leading cause of disability and mortality worldwide. This emphasizes the importance of addressing issues related to the prevention, timely detection and treatment of conditions such as chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD) and COPD with bronchiectasis. The use of highly sensitive methods for monitoring likely exacerbations and predicting the development of comorbidities in this patient cohort is justified.
Objective — to study the nature and severity of changes in the acute phase inflammatory marker — C-reactive protein (CRP) in patients with chronic lung diseases.
Materials and methods. A total of 62 hospitalized patients with CB, COPD and COPD with secondary bronchiectasis were examined. All patients underwent clinical, laboratory and instrumental investigations. The serum CRP level was measured in peripheral blood. A control group comprised 15 practically healthy individuals.
Results and discussion. It was found that chronic inflammatory lung diseases were more prevalent in men (in the CB group — 55.0 %, in the COPD group — 86.96 %, in the COPD with secondary bronchiecta­sis group — 93.7 %). The CRP level in peripheral blood serum was elevated in all groups: in the CB group — (5.5 ± ± 0.12) mg/l, in the COPD group — (7.54 ± 0.98) mg/l, in the COPD with secondary bronchiectasis group — (12.93 ± 1.23) mg/l. This indicator was statistically significantly higher by 4.0, 5.6, and 9.6 times, respectively (all p < 0.001) compared to the control group. The proportion of smokers was 60.0 % in the CB group, 73.9 % in the COPD group and 78.94 % in the COPD with secondary bronchiec­tasis group.
Conclusions. Harmful habits, especially smoking, contribute significantly to the widespread occurrence of chronic lung diseases. Exacerbations and progression of chronic inflammatory processes in the bronchial tree are associated with an elevated level of CRP. The level of CRP significantly increases with the development of concomitant changes, particularly the presence of secondary bronchiectasis. There is a correlation between smoking and the severity of chronic inflammatory lung diseases, as well as a relation­ship between the severity of COPD and the duration of smoking.
Prospects for the use of Lipster Mint cream in the complex treatment of herpes zoster
Authors: Shevchenko O.P. , Bardov P.V. , Razdaibiedin S.N. 
Published: December 2023

Objective — to investigate the clinical efficacy of Lipster Mint cream in the complex treatment of patients with herpes zoster.
Materials and methods. The study included 15 patients (11 women and 4 men) with acute herpes zoster. The age of the patients ranged from 38 to 70 years. The patients had severe clinical symptoms (typical vesicular rash, itching of varying intensity, burning sensation, intense pain along the affected nerves and sleep disturbance). The localization of pathological foci was unilateral: in 12 patients on the skin of the trunk, in 1 patient on the buttock and in 2 patients on the skin of the thigh. All patients reported a decrease in quality of life due to the disease. The complex treatment included Valavir, one of the valacyclovir drugs, according to the recommended regimens, which was administered orally in 1000 mg tablets three times a day for 7 days. Acute herpes-associated pain and heartburn were relieved with analgesics and topical application of Lipster Mint cream, manufactured by Farmak (Ukraine), which contains acyclovir 5 % and menthol. A distinctive advantage of Lipster Mint is that it contains the highest dose of acyclovir permitted for topical products — 5 %, as well as menthol which cools and reduces itching. The effectiveness of treatment of herpes zoster was assessed by the dynamics of clinical symptoms and subjective feelings on the 2nd, 5th and 10th days of treatment.
Results and discussion. As a result of the treatment, positive dynamics of all clinical manifestations was achieved. Inflammatory phenomena such as swelling and hyperemia of the skin significantly decreased, the appearance of fresh herpes rash stopped within 24 hours, body temperature normalized on the 2—3rd day, general condition improved, pain and discomfort in the affected areas significantly decreased, partial epithelialization of erosions and the appearance of crusts were observed on the 5—7th day. With the topical application of Lipster Mint, under the influence of menthol, from the first minutes of application, patients significantly reduced the sensations of burning, tingling and pain in the areas of skin lesions.
Conclusions. Despite the available arsenal of specific and non-specific antiherpetic drugs, treatment of patients suffering from herpes zoster continues to be an urgent medical problem that requires further improvement and individualized approach. Our clinical observations indicate the effectiveness of the systemic drug Valavir and the topical drug Lipster Mint cream in the complex treatment of herpes zoster, which makes it possible to reduce postherpetic neuralgia in the areas of skin lesions and improve the quality of life of patients.
PERANAN KOMUNIKASI PEMASARAN TERPADU DALAM MEMBANGUN KESADARAN MEREK “LOTOTO” PT. GLOBAL TRI SOLUSINDO
Authors: Ramadhani Alifia , Abdurahman Ade Irfan , Khairani Aulian 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui strategi lototo dalam membangun kesadaran merek dengan meninjau peranan teori komunikasi pemasaran terpadu. Diantara kompetitor lainnya, lototo merupakan merek baru yang menjual produk safety lockout tagout, untuk membangun kesadaran merek diperlukan strategi komunikasi pemasaran yang efektif dengan memadukan unsur dari komunikasi pemasaran terpadu Kotler dan Amstrong (2001:600). Penelitian ini menggunakan pendekatan kualitatif deskriptif, dengan teknik pengumpulan data secara observasi, wawancara, dan dokumentasi. Wawancara dilakukan dengan sejumlah informan internal lototo, dan informan eksternal yang merupakan konsumen lototo. Hasil dari penelitian ini mengungkapkan lototo menggunakan unsur komunikasi pemasaran terpadu diantaranya periklanan, sales, promosi penjualan, pemasaran interaktif, dan pemasaran langsung. Kesimpulan dari penelitian ini menunjukan lototo berhasil mengimplementasi peranan teori komunikasi pemasaran terpadu dengan baik yang memadukan unsur komunikasi pemasaran Kotler dan Amstrong (2001:600) dalam membangun kesadaran merek. Kata Kunci: Komunikasi Pemasaran Terpadu; Unsur Komunikasi Pemasaran; Kesadaran Merek.
Проблеми міжнародно-правової відповідальності у випадку припинення існування держави-правопорушниці
Authors: Чвалюк Андрій Миколайович 
Published: December 2023

У доктрині міжнародного права дещо суперечливими є підходи до вирішення проблем правонаступництва держав у сфері правовідносин із відповідальності, які (правовідносини) виникають внаслідок міжнародного правопорушення держави-попередниці. Попри достатню кількість досліджень у зазначеній сфері, єдиного визнаного загального доктринального підходу до регулювання окресленого питання вітчизняними вченими не вироблено. Автор статті наводить аргументи про те, що сучасне міжнародне право містить достатньо правових механізмів для того, щоб реалізувати міжнародно-правову відповідальність держави на випадок припинення існування держави- правопорушниці і ситуації правонаступництва.
Метою статті є розгляд механізмів застосування міжнародної відповідальності до держави-правонаступниці за міжнародні злочини, вчинені державою-попередницею. Методологічну основу дослідження становлять метод контекстуального аналізу, за допомогою якого було окреслено ознаки суб’єкта міжнародного права, та метод прогнозування, що дозволив розглянути факт припинення існування держави як спланований і керований процес, спрямований на уникнення відповідальності.
Опрацювання джерел міжнародного права дозволило авторові встановити, що застосування заходів відповідальності за міжнародні злочини до держав-правонаступниць за дії, вчинені державою- попередницею, є цілком дійовим способом реалізації міжнародно- правової відповідальності. Подібні прецеденти вже мали місце у міжнародних правовідносинах і можуть бути застосовані знов на випадок, якщо Російська Федерація спробує уникнути відповідальності, припинивши своє існування. Якщо новостворені після розпаду Російської Федерації держави свідомо ухиляться від набуття статусу суб’єкта міжнародного права і відмовляться виплатити компенсацію Україні та іншим державам світу, які постраждали від російської агресії, міжнародна спільнота має відмовити їм у визнанні. Лише добровільно обраний курс на міжнародну інтеграцію з дотриманням усіх норм міжнародного права стане гарантією того, що світ не отримає замість Російської Федерації чотири десятки некерованих агресивних країн.
An observational study of microcirculation among healthy individuals by age and sex
Authors: Yang Yun-Ping , Chiu Ching-Tang , Chao Anne , Yeh Yu-Chang , Sun Wei-Zen , Liu Chih-Min , Chan Wing-Sum 
Published: December 2023

OBJECTIVE: This study measured normal ranges of microcirculatory parameters in healthy individuals and investigated differences in parameters by age and sex. METHODS: Participants were enrolled into three groups with equal numbers of male and female: young (20–39 years), middle-aged (40–59 years), and elderly (60–79 years). Sublingual microcirculation images were obtained using the incident dark field (IDF). RESULTS: A total of 75 female and 75 male healthy individuals were enrolled. The elderly group had a higher TVD (26.5 [ 2 ] vs. 25.2 [ 1.8 ]; p = 0.019) and a lower PPV (97 [ 2 ] vs. 98 [ 3 ]; p = 0.03) than did the young group. In the elderly group, systolic blood pressure (SBP) and mean arterial pressure (MAP) were moderately and positively correlated with MFI score ( r = 0.407, p < 0.05, and r = 0.403, p < 0.05, respectively). The female participants had a lower MFI score than did the male participants (2.9 [ 2.8–3 ] vs. 3.0 [ 2.9–3 ]; p = 0.015). CONCLUSIONS: This study revealed the range of microcirculatory parameters between different ages and sexes in healthy individuals. We found that blood pressure levels were correlated with microcirculatory parameters, especially in elders and female.
Digital transformation dilemma in the era of changing dynamics: How organizational culture influence the success of digital transformation
Authors: Alshammari Khalid H. , Alshallaqi Mohammad , Al-Mamary Yaser Hasan 
Published: December 2023

BACKGROUND: Digital transformation has become one of the most important topics in business, as companies try to use technology to improve their processes and gain a competitive edge. However, the success of digital transformation projects can be affected by organizational culture, which can make it easier or harder for digital transformation projects to be successfully implemented. OBJECTIVE: This study seeks to investigate the impact of organizational culture on the success of digital transformation. The study measures dimensions of organizational culture and how they impact the success of digital transformation projects. METHODS: 264 employees from various firms provided information via a questionnaire, and the study used Structural Equation Modelling (SEM) with AMOS software to evaluate the information and develop the proposed conceptual framework. RESULTS: The results demonstrate that employee empowerment has a positive and significant impact on digital transformation, while new organizational practice, support of change, and teamwork do not. CONCLUSIONS: These findings are crucial for advancing the current understanding of the role of organizational culture in the success of digital transformation projects. By shedding light on this relationship, this study contributes to the literature on digital transformation and provides organizations with insights that can inform their digital transformation strategies.
Hybrid deep model for predicting anti-cancer drug efficacy in colorectal cancer patients
Authors: Karthikeyan A. , Jothilakshmi S. , Suthir S. 
Published: December 2023

Cancers are genetically diversified, so anticancer treatments have different levels of efficacy on people due to genetic differences. The main objective of this work is to predict the anticancer drug efficiency for colorectal cancer patients to reduce the mortality rates and provides immune energy for the patients. This paper proposes a novel anti-cancer drug efficacy system in colorectal cancer patients. The input data gene is normalized with the Min–Max normalization technique that normalizes the data in distinct scales. Subsequently, proposes an improved entropy-based feature to evaluate the uncertainty distribution of data, in which it induces weight to overcome the issue of computational complexity. Along with this feature, a correlation-based feature and statistical features are also retrieved. Subsequently, proposes a Recursive Feature Elimination with Hybrid Machine Learning (RFEHML) mechanism for selecting the appropriate feature set by eliminating the recursive features with the aid of hybrid Machine Learning strategies that combine decision tree and logistic regression. Also, the Gini impurity is employed for ranking the feature and selecting the maximum importance score by eliminating the least acquired importance score. Further, proposes a hybrid model for predicting the drug efficiency with the trained feature set. The hybrid model comprises of Long Short-Term Memory (LSTM) and Updated Rectified Linear Unit-Deep Convolutional Neural Network (UReLU-DCNN) model, in which DCNN is modified by updating the activation function at the fully connected layer. Consequently, the learned feature predicts the drug efficacy of anti-cancer in colorectal cancer patients by determining whether the patient is a responder or non-responder of the drug. Finally, the performance of the proposed RFEHML model is compared with other traditional approaches. It is found that the developed method has higher accuracy for each learning percentage, with values of 60LP = 92.48%, 70LP = 94.28%, 80LP = 95.24%, and 90LP = 96.86%, respectively.
Pengaruh Waktu Fermentasi Terhadap Produksi Bioetanol Dari Limbah Kulit Buah
Authors: Zaki Muhammad , Razali Nasrullah , Rizki Muhammad , Fahmi Syahrul 
Published: December 2023

Penelitian ini mangkaji pengaruh waktu fermentasi terhadap produksi bioetanol dari limbah kulit nenas dan kulit jeruk sebagai sumber selulosa. Percobaan dilangsungkan dengan metode sakarifikasi asam dengan menggunakan HCl dan fermentasi anaerobik menggunakan ragi saccharomyces cerevisiae. Â Setelah proses pemurnian produk hasil fermentasi, kadar bioetanol yang paling tinggi dari kulit nenas didapat sebesar 3,3%. Nilai ini dicapai pada saat fermentasi dilangsungkan selama 5 jam dan massa ragi yang ditambahkan sebesar 15 g. Sedangkan kadar bioetanol dari kulit jeruk terttinggi juga diperoleh pada waktu fermentasi 5 jam dan variasi massa ragi seberat 15 g yaitu sebesar 1,7%. Demikian juga halnya dengan volume bioetanol yang dihasilkan setelah pemurnian, dimana volume bioetanol dari limbah kulit nenas lebih banyak diperoleh yaitu sebesar 3,5 mL dibandingkan dengan bioetanol dari limbah kulit jeruk jeruk yaitu hanya sebesar 3,3 mL. Hal ini disebabkan oleh kadar gula yang terkandung didalam kulit nenas lebih tinggi dibandingkan yang terkandung dalam kulit jeruk. Oleh karena itu, pemanfaatan kulit buah nenas dan jeruk dapat digunakan untuk produksi bioetanol melalui pendekatan bioteknologi dengan menggunakan ragi saccharomyces cerevisiae.
Membran Selulosa Asetat Berbasis Nata De Coco Ditinjau Dari Pengaruh Penambahan Zat Aditif Polyethylene Glycol (PEG) Terhadap Permeabilitas (Fluks)
Authors: Fransiska Deswi , Yuliati Selastia , Junaidi Robert 
Published: December 2023

Teknologi membran digunakan dalam industri untuk proses pemisahan maupun pemurnian.Â Salah satu jenis polimer yang sering digunakan untuk membuat membran adalah selulosa asetat yang diperoleh dari Nata de coco. Tujuan dari penelitian ini untuk melihat pengaruh penambahan zat aditif polyethylene glycol terhadap karakterisasi dan kinerja membran selulosa asetat. Penambahan zat aditif polyethylene glycol, 10%, 17%, dan 28% dengan pelarut diklorometana 50% dan selulosa asetat 18%. Membran yang didapatkan dilakukan pengujian morfologiÂ dan uji fluks membran. Hasil morfologi membran yang memenuhi syarat ultrafiltrasi adalah membran A didapatkan ukuran pori 0,618 Âµm, dan membran B sebesar 0,972 Âµm. hasil uji fluks rata-rata didapatkan 15,494 L/m2.jamÂ untuk penambahan zat aditif 10%, 17,764 L/m2.jamÂ untuk penambahan zat aditif 17% dan 19,455 L/m2.jam untuk penambahan zat aditif 28%. Hasil yang diperoleh menunjukkan bahwa pengaruh zat aditifÂ pada membran selulosa asetat yaitu semakin banyak komposisi zat aditif maka semakin besar nilai fluks dan ukuran pori membran.
Analisa Perawatan Mesin Pembentuk Papan Fiber Semen Dengan Menggunakan Metode RCM Di PT. XYZ
Authors: Baihaqi Wildan Khanif , Adesta Deny 
Published: December 2023

PT. XYZÂ merupakan perusahaan yang bergerak di bidang industri papan fiber semen, permasalahan yang Â terjadi pada PT. XYZ adalah sering terjadinya downtime mesin pada mesin pembentuk papan fiber semen. Masalah tersebut dikarenakan cipratan dari proses produksi yang berbahan baku semen sehingga cepat mengeras dan menyebabkan kerak, sehingga dapat memberikan dampak bagi proses produksi. Maka dari itu perlu untuk mengetahui komponen kritis yang sering mengalami kerusakan serta interval waktu yang tepat untuk melakukan pemeriksaan mesin pembentuk papan fiber semen. peneliti menggunakan analisa dengan pendekatan RCM (Reliability Centered Maintenance) untuk mengatasi masalah tersebut. RCM merupakan metode yang berfungsi untuk merancangÂ sebuah desain sistem yang andal dan metode ini dapat memaksimalkan waktu penggunaan mesin serta bisa mengurangi angka downtime mesin. Setelah dilakukan penerapan metode RCM ditemukan komponen kritis dari mesin pembentuk papan fiber semen dengan analisa FMEA yaitu part Bearing VAT dengan RPN 366 dan Flow meter dengan RPN 343. Setelah itu diperoleh nilai MTTR part bearing VAT 2,57876 dan Flow meter 1,96815.serta nilai MTTF part bearing VAT 174,656,dan flow meter 176,971. Kemudian diperoleh interval untuk pemeriksaan partÂ Bearing VAT selama 129,03 jam sekali dan Flow meter selama 163,26 jam sekali.
Pengolahan Limbah Sablon Menggunakan Membran Selulosa Asetat (Ca) Berbasis Pelepah Pisang Secara Mikrofiltrasi
Authors: Wati Ria Praba , Yuliati Selastia , Zaman Muhammad 
Published: December 2023

Sablon merupakan teknik proses cetak yang menggunakan layar dengan kerapatan tertentu dan umumnya berbahan dasar nylon atau sutra. Tujuan penelitian ini adalah menerapkan membran selulosa asetat secara mikrofiltrasi untuk pengolaha limbah sablon. Membran akan dibuat dengan menggunakan selulosa pelepah pisang dengan komposisi 2 gr selulosa pelarut 25 ml aseton dan 1,7 ml PEG 400. Dalam penelitian ini, digunakan limbah cair sablon dengan variasi koagulan yaitu PAC 300; 600; 900; 1200; 1500 ppm serta variasi tekananÂ 0,2 ; 0,4 ; 0,6 ; 0,8Â dan 1 bar. DariÂ hasil penelitian, didapatkan hasil rejeksi logam Cr 68,14 %. pengukuran dilakukan kondisi optimum untuk variasi 0,2-1 bar range pada 0,2 bar dengan koagulan 1200 ppm.
Analisis Nilai Tambah Pengolahan Kopi Robusta di Ud. Cipta Lestari Desa Pujungan Kecamatan Pupuan Kabupaten Tabanan
Authors: Martiningsih Ni Gst. Ag. Gde Eka , Dwi Susanti Ida Ayu Made , Edo Floriana Nonasal 
Published: December 2023

This study aims to determine the amount of added value,processing system,as well as the eligibility obtained by robusta coffee processing businesses in UD Cipta Lestari in producing various coffee products. Research conducted in the processing business UD Cipta Lestari which is one of the small – scale umkm, which produces robusta coffee products in the Village of Pujungan, Subdistrict of Pupuan Tabanan Regency.Processed products from Robusta coffee analyzed were wet coffee beans,dry coffee beans, roasted coffee and packaged coffee.The results of this research analysis that the income of the robusta Coffee Processing Unit in the UD Cipta Lestari Village of Pujungan, Subdistrict of Pupuan Tabanan Regency for the production proses robusta coffee as big Rp. 154.578.400/year. with acceptance 400 kg wet coffee beans as big Rp.43.200.000/year. For 100 kg dry coffee beans for Rp.54.000.000/year, For 80 kg roasting koffee of Rp.67.200.000/year. And for 80 kg packaged coffee as big as Rp. 86.400.000 with total receipts as big Rp.250.800.000/year.Meanwhile, the added value analysis which is obtained by the robusta Coffee Processing Unit in the UD Cipta Lestari Village of Pujungan, Subdistrict of Pupuan Tabanan Regency on the product robusta coffee is Rp. 71.778.400 with added value ratio 71,78 %. With greater added value ≥ 50% hence robusta coffee processing in UD Cipta Lestari provide added value.
Nanopartículas de plata en la odontología. Revisión de la literatura
Authors: Guallpa Guallpa Bryan Alexander , González Campoverde Lorena Alexandra , Pineda Palacios Wilmer Gabriel 
Published: December 2023

Introducción. Las nanopartículas de plata juegan un papel importante en diferentes campos de las ciencias de la salud como la Odontología, estas nano partículas revolucionan la forma en que se realizan diferentes tipos de tratamientos. La aplicación de nano partículas puede mejorar las propiedades físicas y químicas de los materiales dentales, aumentar su eficacia y mejorar el efecto después de la aplicación. Las nano partículas se consideran una tecnología innovadora y prometedora en el campo de la Odontología, ya que pueden optimizar los métodos de diagnóstico y tratamiento tempranos en un tiempo significativamente más corto. Objetivo. Realizar una revisión bibliográfica de las nanopartículas de plata, principalmente sus efectos biológicos y aplicaciones antimicrobianas a nivel odontológico. Metodología. La recolección de información se basó en evidencia científica sobre nanopartículas en el campo de la Odontología, donde las bases de datos utilizadas para la búsqueda de información fueron Scielo, Proquest, Scopus y Dialnet. Se utilizaron operadores booleanos para buscar información: "AND" y "OR". Las palabras clave utilizadas para buscar los artículos correspondieron a "nanopartículas" y "odontología". Resultados. Después de aplicar los criterios de inclusión y exclusión, se estableció el análisis de 900 artículos, de los cuales se pudo identificar 33 como aptos para revisión bibliográfica. Conclusión. Las nanopartículas utilizadas en el campo de la odontología tienen principalmente propiedades antimicrobianas que, al combinarse con otras sustancias y componentes utilizados en la práctica de diferentes campos profesionales de la Odontología, pueden controlar y prevenir la propagación de bacterias. Área de estudio general: Odontología. Área de estudio específica: Ortodoncia. Tipo de estudio: Revisión Bibliográfica.