bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Antihypertensive Medication Adherence Among Historically Underrepresented Adults
Authors: Kokenge Molly C. , Ruppar Todd M. 
Published: January 2024

Background
Addressing disparities in blood pressure control must include supporting antihypertensive medication adherence (MA). Developing effective MA interventions requires identifying the most important factors influencing MA.

Objective
In this review, the authors aimed to meta-analyze the results of research testing associations between factors potentially influencing antihypertensive MA and assessed antihypertensive MA in historically underrepresented populations. Additional exploratory analyses focused on system-level factors, which have been understudied and may particularly impact disparities in MA.

Methods
A health sciences librarian assisted with searching across 10 databases. Inclusion criteria included (1) published in English, (2) sample of adults with hypertension, (3) ≥50% of participants having self-identified as a race/ethnicity underrepresented in the country where the study was conducted, and (4) reporting sufficient data to calculate effect size(s).

Results
Fifty-eight studies were eligible for inclusion. Nine factors met criteria for planned analyses. Older age (r = 0.08, P < .01; k = 26 studies) and higher income (r = 0.11, P = .01; k = 15) were significantly correlated with better MA. Having depressive symptoms was significantly correlated with worse MA (r = −0.18, P < .01; k = 11). Effect sizes for sex, education level, marital status, number of medications, comorbidities, and perceived social support were not significant. System-level factors examined included insurance coverage, access to healthcare, perceived barriers, having a primary care provider, perceptions of their healthcare provider, and experiences of discrimination in healthcare.

Conclusions
Understanding the impact of factors associated with antihypertensive MA in historically underrepresented adults can support development of targeted, culturally relevant MA interventions. Future research should examine the impact of system-level factors on antihypertensive MA among historically underrepresented populations.
Sexual Violence and Social Media Discourse
Authors: Glover Hilary Ashton , Hitt Amanda , Davenport Nikki , Casson Victoria , Blasingame Tabitha 
Published: January 2024

ABSTRACT

Background
Sexual violence is prevalent on college campuses, yet formal disclosure and open dialogue are often muffled. Social media has become a powerful platform for survivors and presents an opportunity for researchers to explore social discourse surrounding sexual violence on campuses. Healthcare providers must be knowledgeable of campus climate surrounding sexual violence to provide patient-centered, trauma-informed care and mitigate the detrimental, long-term effects experienced by survivors.

Methods
Twitter, a social media and networking platform, was used to explore online discourse regarding sexual violence among college students. A conventional qualitative content analysis was implemented using two coders to explore data before identifying themes.

Results
The researchers identified 175 tweets that met the inclusion criteria. Three subthemes emerged: (a) lack of support, (b) powerlessness, and (c) victim blaming and shaming, which built the foundation for the overarching theme of rape culture.

Conclusion
Social media posts provide insight into survivor experiences and offer forensic nurses and healthcare providers the opportunity to discover information that survivors might not otherwise disclose. Forensic nurses should consider implementing innovative approaches to engage campus survivors and increase access to postassault care.
Cardiac sarcoidosis in a patient with ulcerative colitis: A case report and literature review
Authors: Moriichi Kentaro , Kashima Shin , Kobayashi Yu , Sugiyama Yuya , Murakami Yuki , Sasaki Takahiro , Kunogi Takehito , Takahashi Keitaro , Ando Katsuyoshi , Ueno Nobuhiro , Tanabe Hiroki , Date Ayumi , Yuzawa Sayaka , Fujiya Mikihiro 
Published: January 2024

Rationale:
Both ulcerative colitis (UC) and sarcoidosis are chronic inflammatory diseases with unknown etiologies and are rare. However, the odds ratio in UC patients has been reported to range from 1.7 to 2.1, suggesting a potential etiology between sarcoidosis and UC. Furthermore, the underlying etiologies of UC and sarcoidosis remain unidentified. Sharing the experience of a UC patient with cardiac sarcoidosis could provide valuable insights to prevent sudden death in UC patients.

Patient concerns:
A 71-year-old Japanese woman was diagnosed with UC at 58-year-old and maintained remission on mesalazine treatment. She complained of just palpitation; therefore, she consulted a cardiologist.

Diagnoses:
The patient received a diagnosis of cardiac sarcoidosis with complicating ulcerative colitis based on the results of N-terminal prohormone of the brain natriuretic peptide (NT-proBNP), imaging examinations, and histology.

Intervention:
The patient was treated with prednisolone and methotrexate. The prednisolone was then tapered, and the methotrexate dose was adjusted based on her symptoms, imaging results, and laboratory findings.

Outcome:
She no longer had any symptoms, and the abnormal FDG uptake had disappeared after 2 years.

Lesson:
In UC patients, periodic or additional (in case of symptomatic) electrocardiography and NT-proBNP are recommended for the early detection of cardiac sarcoidosis, a life-threatening complication.
Lhermitte-Duclos disease with excessive calcification in a septuagenarian: A case report
Authors: Su Yang , Richard Seidu A. , Lan Zhigang , Zhang Yuekang 
Published: January 2024

Rationale:
Lhermitte-Duclos disease (LDD), or dysplastic cerebellar gangliocytoma (DCG), is a rare tumor originating from the cerebellar cortex. LDD is a benign neuroglial tumor with uncertain prognosis. Over 200 cases have been reported in the literature mostly in the form of case reports. Thus, we present a spectacular case of LDD with excessive calcification in a female septuagenarian.

Patient concerns:
A 72-year-old female presented with progressive dizziness for 8 months and suffered a head and sacrococcygeal region injury 20 days prior to her admission in our neurosurgery department.

Diagnosis:
Computed tomography scan showed a right nonspecific cerebellar mass with striated calcification. Magnetic resonance imaging revealed a right “tiger-striped” alteration of the cerebellar cortex. H&E staining revealed a low grade glial neural tumor which was consistent with the diagnosis of LDD or DCG.

Intervention:
The lesion was total resected.

Outcomes:
The patient recovered well and the cerebellar dysfunctional symptoms subsided 3 months after the operation and 2 years follow-up revealed no recurrence of the lesion and no neurological deficits.

Lesion:
We postulate that the calcification of LDD is age-related and the pathogenesis of disease often observed in young adulthood.
Adjuvant trastuzumab for triple-positive breast cancer with chronic renal failure: A case report and review of literature
Authors: En Wen , Long Yuming 
Published: January 2024

Rationale:
Although the occurrence of combined renal insufficiency among patients with breast cancer is even rarer, it poses a significant challenge in the treatment of these patients. Treating such patients often requires both targeted and endocrine therapies. However, oncologists lack evidence-based guidelines for managing renal function in patients with renal insufficiency.

Patients concern:
A 56-year-old menopausal female with a history of renal failure was diagnosed with triple-positive breast cancer and administered endocrine therapy and targeted therapy associated with hemodialysis after surgery.

Outcomes:
Under the premise of regular dialysis, the patient successfully completed endocrine therapy and targeted therapy for 1 year.

Discussion:
Patients with advanced triple-positive breast cancer, including those undergoing hemodialysis, require a combination of anti-human epidermal growth factor receptor-2 and endocrine therapies, The side effects of these 2 treatment methods are worth considering in patients with renal insufficiency.

Conclusion:
We report a case of triple-positive breast cancer in a patient undergoing hemodialysis. There was no difference in the treatment approach between patients with and without normal renal function.
Effectiveness of acupuncture combined with artificial tears in managing dry eye syndrome: A systematic review and meta-analysis
Authors: Wang Ying , Peng Jun , Xiao Li , Deng Ying , Lu Jing , Zhou Ya-Sha , Yang Yi-Jing , Peng Qing-Hua 
Published: January 2024

Background:
Dry eye syndrome is an ocular surface disease with high incidence. Acupuncture combined with artificial tears is effective for treating dry eye syndrome. This study aimed to evaluate the evidence for the efficacy of acupuncture combined with artificial tears in dry eye syndrome by conducting a systematic review and meta-analysis.

Methods:
A systematic online search was performed from the date of database establishment to July 1, 2023. The study groups that addressed acupuncture combined with artificial tears for patients with dry eye syndrome (DES) and the control groups that addressed artificial tears were analyzed. The main outcomes were tear breakup time (BUT) and Schirmer I test (SIT), assessed as previously described.

Results:
Sixteen randomized or controlled trials met the selection criteria, and 1383 patients with DES were included in this study. The analysis results showed that BUT [Standard mean difference (SMD) = 1.25, 95% confidence interval (CI) (1.14, 1.37), P < .0001], SIT [SMD = 1.55, 95% CI (1.08, 2.02), P < .0001], and corneal fluorescein staining [SMD = –2.08, 95% CI (–2.96, –1.20), P < .00001] significantly improved in the trial groups compared with the control groups. The acupuncture treatment was more effective in reducing the levels of IL-6 (P < .0001) and TNF-α (P < .00001). The overall efficacy rate was better in the trial group than in the control group [odds ratio = 4.09, 95% CI (3.04, 5.51), P < .00001]. However, no significant difference was observed in the ocular surface disease index (P = .15) between the trial and control groups.

Conclusion:
The results of this study indicated that acupuncture combined with artificial tears could be considered safe, effective to patients with DES.
Treatment of gouty arthritis with traditional Chinese medicine decoction: Meta-analysis, network pharmacology analysis, and molecular docking
Authors: Qu Pengda , Du Shiyu , Wang Wei , Peng Zhaorong , Hu Qian , Wang Haiyang , Tang Xiaohu 
Published: January 2024

Background:
Previous studies have shown that traditional Chinese medicine decoction (TCMD) could ameliorate the clinical symptoms and laboratory indicators of gouty arthritis (GA) patients. However, few investigations have been conducted on the efficacy and safety of TCMD for GA, the underlying mechanism of TCMD for GA, and the relationship between the TCMD active ingredients and GA targets.

Methods:
Randomized controlled trials of TCMD for GA were retrieved from Chinese and English databases. Meta-analysis was conducted by Stata 17 software. Potential sources of heterogeneity were identified through subgroup analysis, meta-regression, and heterogeneity test. Publication bias was assessed by Egger’s test and funnel plots. The ingredients and targets related to TCMD and GA were obtained from multiple databases, such as TCMSP and DrugBank. The protein-protein interaction network, GO and KEGG analysis was constructed using STRING and DAVID. Molecular docking and visualization of the results were completed by AutoDock and PyMOL software.

Results:
Eighty-four studies were included, involving 7151 patients and 10 outcome indicators. Meta-analysis showed that, compared to routine treatment, TCMD could better reduce the incidence of adverse events and the level of laboratory indicators including blood uric acid (BUA), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 1β (IL-1β), and tumor necrosis factor-α (TNF-α). In the section of network pharmacology, we retrieved 150 active ingredients and 303 target genes from the top 10 herbs in 84 studies, as well as 3082 disease targets and 195 cross targets of the herbs and GA. The top ranked ingredients, intersection targets, and signaling pathways included quercetin, kaempferol, and wogonin; AKT1, TNF, and TP53; as well as IL-17, HIF-1, and PI3K-AKT, etc. Among the 81 molecular docking results, we visualized 10 results with low binding energy, including IL1B and beta-sitosterol, MYC and beta-sitosterol, etc.

Conclusion:
TCMD could be a satisfactory complementary and alternative therapy for GA. However, it should be verified by further studies. Future research could be conducted from the following active ingredients, targets, and signal pathways, such as wogonin, sitosterol, and sitosterol; AKT1, TNF, IL6, and TP53; and IL-17, HIF-1, and PI3K-AKT signaling pathway.
Extracorporeal life support and continuous renal replacement therapy in a patient with Enterovirus A71 associated cardiopulmonary failure: A case report
Authors: Bao Nguyen Trung , Luan Vo Thanh , Liem Bui Thanh , Nhu Vo Hoang Thien , Viet Do Chau , Tung Trinh Huu , Burza Sakib , Thanh Nguyen Tat 
Published: January 2024

Rationale:
Hand-foot-mouth disease (HFMD) caused by Enterovirus A71, complicated by cardiopulmonary failure, is associated with a high mortality rate despite intensive treatment. To date, there is a paucity of clinical management data, regarding the use of extracorporeal life support (VA-ECMO) for Enterovirus-A71 associated cardiopulmonary failure reported.

Patient concerns:
The patient in this study presented with severe HFMD complicated by cardiopulmonary failure, polymorphic ventricular tachycardia, and cardiac arrest.

Diagnoses:
Clinical presentations, laboratory data, and polymerase chain reaction (PCR) results from rectal swabs were used to confirm the diagnosis of severe HFMD caused by Enterovirus A71.

Interventions:
The patient was managed with chest compression and an automatic external defibrillator, mechanical ventilation, intravenous immunoglobulin (IVIG), continuous renal replacement therapy (CRRT) and inotrope (milrinone). The patient did not respond to these interventions and subsequently required further management with VA-ECMO.

Outcomes:
The patient achieved a favorable outcomes.

Lessons:
Our study highlights that extracorporeal membrane oxygenation and CRRT can enhance the survival outcomes of patients with severe HFMD with cardiopulmonary failure complications. Furthermore, we propose specific indications for the initiation of VA-ECMO.
Prognostic value of circulating tumor cells in patients with recurrent and metastatic colorectal cancer: a systematic review and meta-analysis
Authors: Liu Xia , Lan Hui , Yang Dongmei , Wang Li , Hu Liping 
Published: January 2024

Background:
The detection of circulating tumor cells (CTCs) has been employed in prognosticating the likelihood of recurrence and metastasis in colorectal cancer (CRC). Nonetheless, the findings remain enigmatic. This meta-analysis aims to systematically assess the predictive utility of CTCs detection in postoperative recurrence and metastasis among CRC patients.

Methods:
A comprehensive search of PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Cochrane Library was conducted from inception to March 2023. Pooled estimates including sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and summary receiver operating characteristic curve were computed to gauge the predictive value. The QUADAS-2 tool was employed to appraise bias risks in individual studies. The assessment of publication bias in the included literature was performed using Deek’s funnel plot.

Results:
The study encompassed 16 articles and 2037 patients. After synthesizing the pertinent indices, CTCs monitoring demonstrated sensitivity and specificity of 0.71 (95% confidence interval [CI], 0.62–0.79) and 0.71 (95% CI, 0.55–0.83), respectively. The corresponding values for positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 2.4 (95% CI, 1.5–4.0), 0.41 (95% CI, 0.29–0.58), and 6 (95% CI, 3–13). The summary receiver operating characteristic curve yielded an area under the curve of 0.76 (95% CI, 0.72–0.80). Deek’s funnel plot analysis revealed no significant evidence of publication bias (P = .42).

Conclusion:
This investigation underscores the potential of CTCs detection as a noninvasive modality to efficaciously prognosticate postoperative recurrence and metastasis in CRC.
Relationship between the m-FI 11 score and 2-year survival in octogenarians undergoing colorectal cancer resection
Authors: Ari Kaso , Iqbal Muhammad Rafaih , Crane Jasmine , Borucki Joseph , Nunney Ian , Hernon James , Stearns Adam 
Published: January 2024

Introduction:
The modified Frailty Index (m-FI) offers a simple scoring tool, predicting short-term outcomes in elderly colorectal cancer (CRC) patients. However, links between m-FI scores and 2-year postoperative mortality in octogenarian CRC resection patients remain underexplored. A streamlined frailty index can aid in preoperative assessments to identify elderly patients who are likely to live longer after curative resection surgery to then tailor postoperative care. Our study aims to assess the association between m-FI scores and 2-year postoperative mortality in elderly CRC surgery patients.

Methods:
A retrospective analysis was conducted on a cohort of consecutive patients aged older than or equal to 80 years who underwent colorectal cancer resection at a tertiary referral centre between 2010 and 2017. The m-FI-11 scores less than or equal to two denoted the non-frail category, whereas m-FI scores equal to or exceeding 3 were categorised as frail. The primary outcome measure was defined as 2-year all-cause mortality.

Results:
A total of 337 patients were studied. The 2-year overall survival rate was 83% with an overall median survival time of 84 months (95% CI: 74–94 months). Patients with m-FI scores less than or equal to 2 had a 2-year survival rate of 85% and a median survival time of 94 months (95% CI: 84–104 months). Conversely, patients with m-FI scores greater than or equal to 3 had a 2-year survival rate of 72% and a median survival time of 69 months (95% CI: 59–79 months). An m-FI score greater than or equal to 3 showed a hazard ratio of 1.73 (95% CI: 0.92–3.26, P=0.092) for 2-year mortality compared to an m-FI score less than or equal to 2.

Conclusion:
Higher m-FI scores significantly correlate with an increased 2-year mortality risk among octogenarian CRC resection patients. This highlights the potential of the m-FI as a preoperative tool for identifying patients likely to survive longer post-surgery. Its integration aids in tailored postoperative care strategies, ensuring efficient recovery to functional baselines in this cohort.
Stroke as an unusual initial presentation of ‘malignant’ middle cerebral artery infarction involvement in systemic lupus erythematosus
Authors: Habes Yousef Mahmoud Nimer , Ahmaro Manar , Dwikat Yasmin , Jobran Afnan W. M. , Abunejma Fawzy Mazen , Abdulrazzak Mohammed 
Published: January 2024

Introduction and importance:
SLE, or systemic lupus erythematosus, is a chronic autoimmune condition of uncertain origin characterized by the presence of autoantibodies that target the body’s own antigens.

Case presentation:
A 16-year-old female presented at the emergency room with a right-sided lip droop and subsequently developed symptoms consistent with a malignant hemispheric infarction, including altered consciousness, hemiplegia, and forced gaze deviation. Her laboratory results were within the normal range. However, a brain MRI revealed cerebral edema and a massive infarction in the middle cerebral artery (MCA) region. Subsequently, her serologic profile was indicative of SLE, leading to a later diagnosis.

Clinical discussion:
The patient in this case presented with symptoms suggestive of a stroke. A CT scan showed MCA occlusion, leading to a diagnosis of malignant MCA syndrome. The patient was also diagnosed with systemic lupus erythematosus, which is associated with an increased risk of stroke. Inflammation-induced thrombosis and CNS vasculitis are potential mechanisms linking SLE and stroke.

Conclusion:
This case serves as an example of a sudden and potentially life-threatening presentation of SLE, underscoring the importance of early detection and targeted treatment that can influence the course of the disease.
Spontaneous spinal epidural haematoma following COVID-19 vaccination: a case report
Authors: Rezvani Majid , Sabouri Masih , Aminmansour Bahram , Falahpour Soheil , Sourani Arman , Sharafi Mohammad , Baradaran Mahdavi Sadegh , Foroughi Mina , Nik Khah Roham , Sourani Armin , Veisi Shaahin 
Published: January 2024

Introduction:
COVID-19 vaccination side effects are rare but important medical situations. Spine-affecting side effects are amongst the rarest, but exceedingly important. Haemorrhagic spinal manifestations of COVID-19 and its vaccines are less reported with little knowledge about them.

Case presentation:
An 80-year-old male who received his first shot of the COVID-19 vaccine had developed COVID-19 pneumonia, weakness, and sensory problems in his legs followed by sphincter incontinence within 5 days period. MRI showed a spontaneous epidural spinal epidural haematoma (SSEDH) in T10–L1. He underwent laminectomy and haematoma evacuation. One month follow-up showed no clinical improvement.

Discussion:
To our knowledge, this was the first post-vaccination SSEDH and second in haemorrhagic spinal complications following COVID-19 vaccination. Considering the neuropathogenesis pathway of COVID-19 and its vaccines, there are common mechanisms of action that could potentially justify post-vaccination SSEDH such as seen in COVID-19 infection, itself. Early Neurosurgical intervention and better preoperative neurological status could be a beneficial modifier for favourable clinical outcomes.

Conclusion:
SSEDH and COVID-19 vaccine coincidence is a rare clinical event, still no solid association could be scientifically explained. Further studies are required for a reliable pathophysiologic association. Early diagnosis, interdisciplinary medical approach, and faster intervention are the cornerstone of the treatment paradigm.