bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Lung Health Check: breast related incidental findings—imaging appearances and lessons learned
Authors: Matthews Suzanne , Kyi Moe , Nasimudeen Abdul , Marusic Ante , Johns Christopher S , Page Jason 
Published: January 2024

Abstract

Objective
The introduction of Targeted Lung Health Checks (TLHC) to screen for lung cancer has highlighted that incidental findings are common and require management strategies. This study analyses retrospectively, incidentally detected breast lesions reported as part of the TLHC referred to the Breast Cancer clinicians.

Methods
All participants with incidental breast nodules referred to the Breast Cancer team in the first year of screening were reviewed.

Results
Fifty-two participants (48 female; 92.3%) were referred to the Breast Multidisciplinary Team Meeting for assessment of 43 breast nodules, 8 breast asymmetry/dense breasts, and 2 likely breast related metastatic disease. One participant declined breast team referral. For the 42 breast nodules investigated, the final diagnoses were 5 breast carcinomas, 10 normal breast tissue, and 27 benign nodules. One male patient was diagnosed with breast carcinoma. The 29 breast nodules classified as smooth and well defined were all benign. No malignancy was demonstrated in the group with asymmetric or dense breast tissue. Metastatic breast carcinoma was confirmed in two participants. Twenty-six out of thirty-seven (54%) females had prior breast screening mammograms precluding further investigation.

Conclusion
Incidental breast nodules are common on THLC scans. Smooth, sharply defined breast nodules are likely to be benign but low-dose CT is poor at accurately assessing breast nodules. Agreed breast referral pathways prior to starting the Lung Cancer Screening programme are recommended. Access to screening mammograms can reduce referrals to the Breast clinic.

Advances in knowledge
Lessons learned from TLHC pilot studies can be useful to sites commencing national TLHC programme.
Foreign Policy as the Continuation of Domestic Politics by Other Means: Pathways and Patterns of Populist Politicization
Authors: Cadier David 
Published: January 2024

Abstract
This article argues that populism in power translates into a greater tendency to politicize foreign policy, in the sense of defining and articulating foreign policy preferences in opposition to political predecessors, using foreign policy as an instrument and ground to battle political opponents, and over-prioritizing domestic incentives and considerations over external ones. Paradoxically, compared to other classical determinants of foreign policy, how populism relates to domestic political competition has received scant attention. Yet, populist actors’ strategies in dealing with political opposition are at the same time distinctive and consequential. This article advances a typological theoretical framework shedding light on the pathways, patterns, and implications of populist politicization, which it illustrates empirically with reference to the case of Poland.
Dietary Patterns and Risk of Inflammatory Bowel Disease: A Systematic Review of Observational Studies
Authors: Khademi Zainab , Pourreza Sanaz , Amjadifar Anis , Torkizadeh Mohammadsadegh , Amirkhizi Farshad 
Published: January 2024

Abstract

Background
The incidence of inflammatory bowel disease (IBD) is increasing worldwide. Dietary patterns may be associated with odds of this disease. Although previous reviews have attempted to summarize the evidence in this field, the growing body of investigations prompted us to conduct an updated comprehensive systematic review.

Methods
We used the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines to evaluate the association between dietary patterns before disease onset and the risk of IBD. PubMed, SCOPUS, and Web of Science were searched using structured keywords up to November 20, 2023.

Results
Twenty-four publications (13 case-control, 1 nested case-control, and 10 cohort studies) were included in this review. The sample size of these studies ranged from 181 to 482 887 subjects. The findings were inconsistent across the included studies, showing inverse, direct, or no association between different dietary patterns and the risk of IBD.

Conclusions
This review provides comprehensive data on the link between dietary patterns prior to IBD diagnosis and risk of this condition. The explicit finding of present review is the extent gap in our knowledge in this field. Therefore, large-scale, high-quality studies are warranted to improve our understanding of the relationship between dietary patterns and IBD risk.
Regulation of innate immune and inflammatory responses by supersulfides
Authors: Tsutsuki Hiroyasu , Zhang Tianli , Akaike Takaaki , Sawa Tomohiro 
Published: January 2024

AbstractInnate immunity plays an important role in host defense against microbial infections. It also participates in activation of acquired immunity through cytokine production and antigen presentation. Pattern recognition receptors such as Toll-like receptors and nucleotide oligomerization domain-like receptors sense invading pathogens and associated tissue injury, after which inflammatory mediators such as pro-inflammatory cytokines and nitric oxide are induced. Supersulfides are molecular species possessing catenated sulfur atoms such as persulfide and polysulfide moieties. They have recently been recognized as important regulators in cellular redox homeostasis by acting as potent antioxidants and nucleophiles. In addition, recent studies suggested that supersulfides are critically involved in the regulation of innate immune and inflammatory responses. In this review, we summarize current knowledge of the chemistry and biology of supersulfides, with particular attention to their roles in regulation of innate immune, and inflammatory responses. Studies with animal models of infection and inflammation demonstrated the potent anti-inflammatory functions of supersulfides such as blocking pro-inflammatory signaling cascades, reducing oxidative stresses, and inhibiting replication of microbial pathogens including severe acute respiratory syndrome coronavirus 2. Precise understanding of how supersulfides regulate innate immune responses is the necessary requirement for developing supersulfide-based diagnostic as well as therapeutic strategies against inflammatory disorders.
Pathomolecular epidemiology, antimicrobial resistance, and virulence genes of Streptococcus dysgalactiae subsp. equisimilis isolates from slaughtered pigs in India
Authors: Patel Sagar M , Sahoo Monalisa , Thakor Jigarji Chaturji , Murali Dinesh , Kumar Pradeep , Singh Rajendra , Singh Karam Pal , Saikumar G , Jana Chandrakanta , Patel Shailesh Kumar , Mote Akash B , Karthikeyan Ravichandran , Vandre Rajesh Kumar , Biswal Jitendra Kumar , Sahoo Nihar Ranjan 
Published: January 2024

Abstract

Aims
We aimed to investigate the prevalence, pathology, and characterization of Streptococcus dysgalactiae subsp. equisimilis (SDSE) in slaughtered pigs of India.

Methods and results
We collected 1254 morbid tissues (lungs—627 and spleen—627) and 627 heart-blood from 627 slaughtered pigs. The bacterial isolation, antibiogram, virulence gene profiling, and mouse pathogenicity testing were performed for the detection and characterization of SDSE. A total of 177 isolates (heart-blood—160 and tissues—17) were recovered from 627 slaughtered pigs with higher isolation rate in heart-blood (25.51%). The prevalence of SDSE was 11% in morbid tissues by polymerase chain reaction. Majority of isolates showed higher detection of streptolysin O, followed by streptokinase and extracellular phospholipase A virulence genes with higher degree of resistance to azithromycin, clindamycin, erythromycin, and penicillin antibiotics. Mouse pathogenicity testing confirmed virulence based on histopathological lesions and re-isolation of SDSE.

Conclusions
Our findings highlight the high prevalence of SDSE in slaughtered pigs. The presence of virulence genes and mouse pathogenicity testing confirm their pathogenic potential.
Effects of bacterial direct-fed microbial mixtures offered to beef cattle consuming finishing diets on intake, nutrient digestibility, feeding behavior, and ruminal kinetics/fermentation profile
Authors: Silva Kaliu G Scaranto , Sarturi Jhones O , Johnson Bradley J , Woerner Dale R , Lopez Alejandra M , Rodrigues Barbara M , Nardi Kaue T , Rush Camron J 
Published: January 2024

Abstract
Effects of bacterial direct-fed microbial (DFM) mixtures on intake, nutrient digestibility, feeding behavior, ruminal fermentation profile, and ruminal degradation kinetics of beef steers were evaluated. Crossbred Angus ruminally cannulated steers (n = 6; body weight [BW] = 520 ± 30 kg) were used in a duplicated 3 × 3 Latin square design and offered a steam-flaked corn-based finisher diet to ad libitum intake for 3, 28-d periods. Treatments were 1) Control (no DFM, lactose carrier only); 2) Treat-A (Lactobacillus animalis, Propionibacterium freudenreichii, Bacillus subtilis, and Bacillus licheniformis), at 1:1:1:3 ratio, respectively; totaling 6 × 109 CFU (50 mg)/animal-daily minimum; and 3) Treat-B, the same DFM combination, but doses at 1:1:3:1 ratio. Bacterial counts were ~30% greater than the minimum expected. Data were analyzed using the GLIMMIX procedure of SAS with the model including the fixed effect of treatment and the random effects of square, period, and animal (square). For repeated measure variables, the fixed effects of treatment, time, and their interaction, and the random effects of square, period, animal (square), and animal (treatment) were used. Preplanned contrasts comparing Control × Treat-A or Treat-B were performed. Intake and major feeding behavior variables were not affected (P ≥ 0.17) by treatments. Steers offered Treat-A had an increased (P = 0.04) ADF digestibility compared with Control. Steers offered Treat-A experienced daily 300 min less (P = 0.04) time under ruminal pH 5.6, a greater (P = 0.04) ruminal pH average and NH3–N concentration (P = 0.05) and tended (P = 0.06) to have a lower ruminal temperature compared to Control. Ruminal VFA was not affected (P ≥ 0.38) by treatments. Steers offered Treat-A increased (P = 0.02) and tended (P = 0.08) to increase the ruminal effective degradable NDF and ADF fractions of the diet-substrate, respectively. When the forage-substrate (low quality) was incubated, steers offered Treat-A tended (P = 0.09) to increase the effective degradable hemicellulose fraction compared to Control. In this experiment, the bacterial combinations did not affect intake and feeding behavior, while the combination with a greater proportion of B. licheniformis (Treat-A) elicited an improved core-fiber digestibility and a healthier ruminal pH pattern, in which the ruminal environment showed to be more prone to induce the effective degradability of fiber fractions, while also releasing more NH3–N.
Social Distancing or Socially Dividing? A Greater Proportion of Vulnerable Patients Admitted to a Metropolitan Burn Center During the COVID-19 Pandemic
Authors: Choe Deborah , Won Paul , Stanton Eloise , Abu-Ghazaleh Joshua , Collier Zachary , Panhassi Daniel , Yenikomshian Haig A , Gillenwater Justin 
Published: January 2024

Abstract
Due to stay-at-home mandates and social distancing, we hypothesized the coronavirus disease 2019 global pandemic altered the epidemiology of burn injuries that presented to a single-institution, metropolitan burn center. A retrospective review of adult and pediatric patients admitted to the center during a 3-year period: 3/20/19-3/19/20 (pre-pandemic year), 3/20/20-3/19/21 (pandemic year 1), and 3/20/21-3/19/22 (pandemic year 2). Variables included patient demographics, burn injury, and hospitalization characteristics. A greater proportion of males compared to females were admitted during the pre-pandemic year with a significant increase in this difference during pandemic year 1 (P &lt; .05). There was a significant increase in the proportion of undomiciled patients admitted between the pre-pandemic year and pandemic year 2 (P &lt; .01). There were significant increases in the proportion of admitted patients who were uninsured, had a history of mental illness and/or substance abuse between pandemic years 1 and 2 (P &lt; .001, P &lt; .05, P &lt; .01) and between the pre-pandemic year and pandemic year 2 (P &lt; .001, P &lt; .01, P &lt; .001). There were significant differences in deepest burn depth and burn etiology between individual years. The proportion of patients with burns treated purely non-operatively significantly increased during pandemic year 1 (P &lt; .05). Greater changes in the demographics of patients with burns admitted after the onset of the pandemic were reported compared to the characteristics and management of their burn injuries. Overall, this study demonstrated that a greater proportion of vulnerable patients were admitted during the pandemic, providing a better understanding of existing health disparities and the differential impact of the pandemic on lower socioeconomic populations.
Drift drives the evolution of chromosome number I: The impact of trait transitions on genome evolution in Coleoptera
Authors: Blackmon Heath , Jonika Michelle M , Alfieri James M , Fardoun Leen , Demuth Jeffery P 
Published: January 2024

Abstract
Chromosomal mutations such as fusions and fissions are often thought to be deleterious, especially in heterozygotes (underdominant), and consequently are unlikely to become fixed. Yet, many models of chromosomal speciation ascribe an important role to chromosomal mutations. When the effective population size (Ne) is small, the efficacy of selection is weakened, and the likelihood of fixing underdominant mutations by genetic drift is greater. Thus, it is possible that ecological and phenotypic transitions that modulate Ne facilitate the fixation of chromosome changes, increasing the rate of karyotype evolution. We synthesize all available chromosome number data in Coleoptera and estimate the impact of traits expected to change Ne on the rate of karyotype evolution in the family Carabidae and 12 disparate clades from across Coleoptera. Our analysis indicates that in Carabidae, wingless clades have faster rates of chromosome number increase. Additionally, our analysis indicates clades exhibiting multiple traits expected to reduce Ne, including strict inbreeding, oligophagy, winglessness, and island endemism, have high rates of karyotype evolution. Our results suggest that chromosome number changes are likely fixed by genetic drift despite an initial fitness cost and that chromosomal speciation models may be important to consider in clades with very small Ne.
Decreased percentages of plasmacytoid dendritic cells predict survival in critically ill patients
Authors: Steinacher Eva , Lenz Max , Krychtiuk Konstantin A , Hengstenberg Christian , Huber Kurt , Wojta Johann , Heinz Gottfried , Niessner Alexander , Speidl Walter S , Koller Lorenz 
Published: January 2024

Abstract
Critically ill patients admitted to intensive care units (ICUs) experience a broad variety of life-threatening conditions. Irrespective of the initial cause of hospitalization, many experience systemic immune dysregulation. Dendritic cells (DCs) are the most potent antigen-presenting cells and play a pivotal role in regulating the immune response by linking the innate to the adaptive immune system. The aim of this study was to analyze whether DCs or their respective subsets are associated with 30-d mortality in an unselected patient cohort admitted to a medical ICU with a cardiovascular focus. A total of 231 patients were included in this single-center prospective observational study. Blood was drawn at admission and after 72 h. Subsequently, flow cytometry was utilized for the analysis of DCs and their respective subsets. In the total cohort, low percentages of DCs were significantly associated with sepsis, respiratory failure, and septic shock. In particular, a significantly lower percentage of circulating plasmacytoid DCs (pDCs) was found to be a strong and independent predictor of 30-d mortality after adjustment for demographic and clinical variables with an hazard ratio of 4.2 (95% confidence interval: 1.3–13.3, P = 0.015). Additionally, low percentages of pDCs were correlated with additional markers of inflammation and organ dysfunction. In conclusion, we observed low percentages of DCs in patients admitted to an ICU experiencing sepsis, respiratory failure, and cardiogenic shock, suggesting their depletion as a contributing mechanism for the development of immune paralysis. In our cohort, pDCs were identified as the most robust subset to predict 30-d mortality.
Colorectal cancer screening test exposure patterns in US adults 45 to 49 years of age, 2019-2021
Authors: Star Jessica , Siegel Rebecca L , Minihan Adair K , Smith Robert A , Jemal Ahmedin , Bandi Priti 
Published: January 2024

Abstract
Several organizations now recommend that individuals at average risk for colorectal cancer (CRC) begin screening at 45 rather than 50 years of age. We present contemporary estimates of CRC screening in newly eligible adults aged 45 to 49 years between 2019 and 2021. Nationally representative prevalence estimates and population number screened were estimated based on the National Health Interview Survey. A logistic regression model assessed CRC screening prevalence differences by survey year and sociodemographic characteristics. In 2021, 19.7%—that is, fewer than 4 million of the eligible 19 million adults aged 45 to 49 years—were up-to-date on CRC screening. Screening was lowest in those who were uninsured (7.6%), had less than a high school diploma (15.4%), and Asian (13.1%). Additionally, fecal occult blood test and/or fecal immunochemical testing was underused, with only 2.4% (&lt;460 000 people) reporting being up-to-date with screening using this modality in 2021. CRC screening in eligible young adults remains low. Concerted efforts to improve screening are warranted, particularly in underserved populations.
Policy evaluation for temporal and/or spatial dependent experiments
Authors: Luo Shikai , Yang Ying , Shi Chengchun , Yao Fang , Ye Jieping , Zhu Hongtu 
Published: January 2024

Abstract
The aim of this article is to establish a causal link between the policies implemented by technology companies and the outcomes they yield within intricate temporal and/or spatial dependent experiments. We propose a novel temporal/spatio-temporal Varying Coefficient Decision Process model, capable of effectively capturing the evolving treatment effects in situations characterized by temporal and/or spatial dependence. Our methodology encompasses the decomposition of the average treatment effect into the direct effect (DE) and the indirect effect (IE). We subsequently devise comprehensive procedures for estimating and making inferences about both DE and IE. Additionally, we provide a rigorous analysis of the statistical properties of these procedures, such as asymptotic power. To substantiate the effectiveness of our approach, we carry out extensive simulations and real data analyses.
Sigmoid colon pseudotumor of actinomycosis: a rare case
Authors: Lesmana Andy , Wirdhani Vika , Perangin Angin Lenti B R , Muzakky Muhamad I , Hayon Stefi G V , Sholihah Mentari M , Hanif Muhammad I 
Published: January 2024

Abstract

Actinomycosis is a chronic suppurative infection caused by gram-positive bacteria, Actinomyces, which commonly colonize the oral cavity, urogenital tract and gastrointestinal tract. It causes opportunistic infection where the mucosal barrier is compromised and is often misdiagnosed as malignancy. We report a case of a 58-year-old female with severe abdominal pain and a palpable tender mass in the left lower quadrant. Computed tomography scan with contrast showed thickening of the transverse, descending to sigmoid colon wall and intense contrast enhancement resembling colitis with mesenteritis. At laparotomy, we found an adherent mass involving sigmoid colon with adjacent small bowel and peritoneum. We decided to perform adhesiolysis and Hartmann procedure. The culture result was negative, whereas the biopsy of sigmoid colon revealed characteristic sulfur granules of actinomycosis colony. Intravenous antibiotic combination of ceftazidime and metronidazole was administered for 14 days followed by complete resolution of symptoms. Histopathological and bacteriological examinations are keys to diagnose actinomycosis. Patients require long-term antibiotic therapy, but surgery is often required because preoperative diagnosis is difficult.

Main novel aspects?
Conjugate Multimode Heat Transfer Analysis of Cryogenic EXLO Manipulation
Authors: Beggs Kyle W , Kassab Alain J , Colletta Michael , Yu Yue , Kourkoutis Lena F , Darwish Ahmed A , Giannuzzi Lucille A 
Published: January 2024

Abstract
In this study, a conjugate radiation/conduction multimode heat transfer analysis of cryogenic focused ion beam (FIB) milling steps necessary for producing ex situ lift out specimens under cryogenic conditions (cryo-EXLO) is performed. Using finite volume for transient heat conduction and enclosure theory for radiation heat transfer, the analysis shows that as long as the specimen is attached or touching the FIB side wall trenches, the specimen will remain vitreous indefinitely, while actively cooled at liquid nitrogen (LN2) temperatures. To simulate the time needed to perform a transfer step to move the bulk sample containing the FIB-thinned specimen from the cryo-FIB to the cryo-EXLO cryostat, the LN2 temperature active cooling is turned off after steady-state conditions are reached and the specimen is monitored over time until the critical devitrification temperature is reached. Under these conditions, the sample will remain vitreous for &gt;3 min, which is more than enough time needed to perform the cryo-transfer step from the FIB to the cryostat, which takes only ∼10 s. Cryo-transmission electron microscopy images of a manipulated cryo-EXLO yeast specimen prepared with cryo-FIB corroborates the heat transfer analysis.
Revisiting the membership, multiplicity, and age of the Beta Pictoris Moving Group in the Gaia era
Authors: Lee Rena A , Gaidos Eric , van Saders Jennifer , Feiden Gregory A , Gagné Jonathan 
Published: January 2024

ABSTRACT
Determining the precise ages of young (tens to a few hundred Myr) kinematic (‘moving’) groups is important for placing star, protoplanetary disc, and planet observations on an evolutionary timeline. The nearby ∼25 Myr-old β Pictoris Moving Group (BPMG) is an important benchmark for studying stars and planetary systems at the end of the primordial disc phase. Gaia DR3 astrometry and photometry, combined with ground-based observations and more sophisticated stellar models, permit a systematic re-evaluation of BPMG membership and age. We combined Gaia astrometry with previously published radial velocities to evaluate moving group membership in a Bayesian framework. To minimize the effect of unresolved stellar multiplicity on age estimates, we identified and excluded multistar systems using Gaia astrometry, ground-based adaptive optics imaging, and multi-epoch radial velocities, as well as literature identifications. We estimated age using isochrone and lithium-depletion-boundary fitting with models that account for the effect of magnetic activity and spots on young, rapidly rotating stars. We find that age estimates are highly model-dependent; Dartmouth magnetic models with ages of 23 ± 8 and 33$^{+9}_{-11}$ Myr provide best fits to the lithium depletion boundary and Gaia MG versus BP–RP colour–magnitude diagram, respectively, whereas a Dartmouth standard model with an age of 11$^{+4}_{-3}$ Myr provides a best fit to the 2-Micron All-Sky Survey-Gaia$M_{K_S}$ versus BP–RP colour–magnitude diagram.