P-233. Catheter-Related Bloodstream Infection (CRBSI) and Catheter-Associated Bloodstream Infection (CABSI) Outside of the Intensive Care Unit (ICU): Preliminary Insights from an Italian Monocentric Study
Authors: Scaglione Giovanni , Colaneri Marta , Borgonovo Fabio , Genovese Camilla , Galli Lucia , Fattore Rebecca , Schiavini Monica , Fassio Federico , Taino alba , Casella Francesco , Calloni Maria , Offer Martina , Gidaro Antonio , Gori Andrea , Foschi Antonella 
Published: January 2025

Abstract

Background
Vascular access device (VAD) placement is an increasingly performed procedure linked to hospital-acquired bloodstream infections.
VADs comprise peripheral venous catheters (mid-tight, mini-midline, midline), centrally (CICC, FICC), and peripherally (PICC) inserted central venous catheters. CRBSI and CABSI definitions are often improperly used, and data beyond ICU settings are scarce.
This study investigates risk factors and the prevalence and incidence of CABSI and CRBSI episodes in non-ICU wards.Table 1.Characteristics and outcomes of the study populationImmunosuppression: active onco-hematological, rheumatological disorder, solid organ transplant, hematopoietic stem-cell transplantation, or recent (&lt;1 year) treatment, with chemotherapy or prolonged immunosuppressive treatment of any of these conditions.PiCC: Peripherally inserted Central venous Catheter, CiCC: Centrally inserted Central venous Catheter, FiCC: Femorally inserted Central venous Catheter

Methods
This retrospective, observational study (January 2021- December 2023) was conducted in Luigi Sacco Hospital, Milan. Clinical and demographic data of hospitalized non-ICU patients undergone VAD placement were retrieved from medical records.
Continuous variables were described with median and interquartile [IQR], and categorical variables with counts and percentiles. A multivariable logistic regression accounting for patients’ and VADs’ characteristics was performed.Figure 1.Microbiological data of CABSI (top) and CRBSI (bottom) episodesMSSA: Methicillin-sensible S.aureus, MRSA: Methicillin-resistant S.aureus, MSSE: Methicillin-sensible S.epidermidis, MRSE: Methicillin-resistant S.epidermidis, Enterobacterales WT: sensible to III gen. cefalosporins, CP: carbapenemase-producing, VRE: Vancomycin-resistant Enterococci, CoNS: Coagulase-negative Staphylococci

Results
A total of 1999 VAD placements were included, patients’ characteristics and outcomes are outlined in Table 1.
Peripheral devices were 66.4%, and 54 CRBSI and 86 CABSI events were identified, according to international guidelines. CABSI and CRBSI displayed prevalence rates of 0.049 and 0.033, and incidences of 1.85 and 1.16 episodes per 1000 catheter days respectively. Parenteral nutrition was the only factor associated with CABSI and CRBSI events (p&lt; 0.0001).
Coagulase-negative Staphylococci (CoNS) were isolated in 37.0% of CABSI, and 31.9% of CRBSI episodes, most frequently S.epidermidis (16%), followed by E.fecium, and E.fecalis, resistant to first-line agents in 59.2%, 35.3%, and 18.8% of cases respectively. Candida spp. was isolated in 12.4% of cases, and polymicrobial etiology was 17.9%.
Pathogens’ prevalence and susceptibility profiles are depicted in Figure 1.

Conclusion
We observed low CRBSI and CABSI incidences in non-ICU wards. CoNs were most prevalent, and parenteral nutrition was associated with VAD-related infections, as already described.
Despite the non-ICU setting, Candida, drug-resistant GNB, and polymicrobial infection rates were alarming, stressing the importance of correct VAD management in non-ICU wards to prevent difficult-to-treat infections.

Disclosures
All Authors: No reported disclosures