bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin Cancers in Medicare Beneficiaries With Actinic Keratoses
Authors: Mohr Cassandra , Li Yao , Navsaria Lucy J. , Hinkston Candice L. , Shete Sanjay S. , Margolis David J. , Wehner Mackenzie R. 
Published: November 2023

ImportanceActinic keratoses (AK) are common premalignant skin lesions with a small risk of progressing to cutaneous squamous cell carcinoma (SCC). There is some evidence that patients with AKs also have increased risks of other skin cancers beyond SCC. However, the absolute risks of skin cancer in patients with AKs are unknown.ObjectiveTo calculate the absolute and relative risks of future skin cancer in Medicare beneficiaries with AKs.Design, Setting, and ParticipantsThis retrospective cohort study was performed using a deidentified, random sample of 4 999 999 fee-for-service Medicare beneficiaries from 2009 through 2018. Patients with treated AKs were included, and patients with seborrheic keratoses (SKs) were included as a comparator group. All patients were required to have at least 1 year between data set entry and first AK or SK. Patients with a history of skin cancer were excluded. Data were analyzed from September 2022 to March 2023.Main Outcomes and MeasuresOutcomes were first surgically treated skin cancer, including keratinocyte carcinoma (including SCC and basal cell carcinoma [BCC]) and melanoma. The absolute risks of skin cancer in patients with AKs were evaluated. Skin cancer risks in patients with AKs were compared with patients with SKs using adjusted competing risks regression.ResultsA total of 555 945 patients with AKs (mean [SD] age, 74.0 [7.4] years; 55.4% female) and 481 024 patients with SKs (mean [SD] age, 73.3 [7.3] years; 72.4% female) were included. The absolute risk of skin cancer after a first AK was 6.3% (95% CI, 6.3%-6.4%) at 1 year, 18.4% (95% CI, 18.3%-18.5%) at 3 years, and 28.5% (95% CI, 28.4%-28.7%) at 5 years. Patients with AKs had increased risk of skin cancer compared with patients with SKs (any skin cancer: adjusted hazard ratio [aHR], 2.17; 95% CI, 2.15-2.19; keratinocyte carcinoma: aHR, 2.20; 95% CI, 2.18-2.22; SCC: aHR, 2.63; 95% CI, 2.59-2.66; BCC: aHR, 1.85; 95% CI, 1.82-1.87; and melanoma: aHR, 1.67; 95% CI, 1.60-1.73).Conclusions and RelevanceIn this cohort study, older patients with AKs had substantial absolute risks, as well as elevated relative risks, of skin cancer. AKs may be clinical markers of UV exposure and increased skin cancer risk, including SCC, BCC, and melanoma. However, guidelines are lacking for follow-up skin cancer surveillance in patients with AKs. Efforts to develop evidence-based recommendations for skin cancer surveillance in patients with AKs are paramount.
Mesoscopic Supramolecular Assembly of Stereolithographically Printed Microgels
Authors: Keutgen Aileen , Klein Ina , Shi Feng , Kuehne Alexander J. C. 
Published: November 2023

AbstractMicrogels that assemble upon issuing of a trigger open up miscellaneous applications in soft robotics, drug delivery, and life‐like materials, due to their unique physical and chemical properties. In this work, a novel hydrogel photoresist system is formulated, consisting of 2‐hydroxyethyl acrylate, ethylene glycol diacrylate, and phenyl bis(2,4,6‐trimethylbenzoyl) phosphine oxide, as well as redox‐sensitive supramolecular host‐guest association motifs. Complex and multi‐compartmented geometries with precisely located recognition motifs are printed in high resolution, resulting in multifunctional structured microgel building blocks for mesoscopic self‐assembly. An enzymatic feedback system is employed to dissipatively assemble and disassemble the redox‐active microgel building blocks in a temporally and spatially controlled pathway. The self‐assembling photoresist system is characterized in terms of the lower critical solution temperature, swelling behavior, and printability. The present work provides new perspectives for the design of tailor‐made mesoscopic microgels with customizable functionality and high applicability for various technological applications.
Nanoscale Chemical Diversity of Coke Deposits on Nanoprinted Metal Catalysts Visualized by Tip‐Enhanced Raman Spectroscopy
Authors: Filez Matthias , Walke Peter , Le‐The Hai , Toyouchi Shuichi , Peeters Wannes , Tomkins Patrick , Eijkel Jan C. T. , De Feyter Steven , Detavernier Christophe , De Vos Dirk E. , Uji‐I Hiroshi , Roeffaers Maarten B. J. 
Published: November 2023

AbstractCoke formation is the prime cause of catalyst deactivation, where undesired carbon wastes block the catalyst surface and hinder further reaction in a broad gamut of industrial chemical processes. Yet, the origins of coke formation and their distribution across the catalyst remain elusive, obstructing the design of coke‐resistant catalysts. Here, the first‐time application of tip‐enhanced Raman spectroscopy (TERS) is demonstrated as a nanoscale chemical probe to localize and identify coke deposits on a post‐mortem metal nanocatalyst. Monitoring coke at the nanoscale circumvents bulk averaging and reveals the local nature of coke with unmatched detail. The nature of coke is chemically diverse and ranges from nanocrystalline graphite to disordered and polymeric coke, even on a single nanoscale location of a top‐down nanoprinted SiO2‐supported Pt catalyst. Surprisingly, not all Pt is an equal producer of coke, where clear isolated coke “hotspots” are present non‐homogeneously on Pt which generate large amounts of disordered coke. After their formation, coke shifts to the support and undergoes long‐range transport on the surrounding SiO2 surface, where it becomes more graphitic. The presented results provide novel guidelines to selectively free‐up the coked metal surface at more mild rejuvenation conditions, thus securing the long‐term catalyst stability.
Atomic Structure of a DNA‐Stabilized Ag11 Nanocluster with Four Valence Electrons
Authors: Rück Vanessa , Neacșu Vlad A. , Liisberg Mikkel B. , Mollerup Christian B. , Ju Park Hee , Vosch Tom , Kondo Jiro , Cerretani Cecilia 
Published: November 2023

AbstractThe combination of mass spectrometry and single crystal X‐ray diffraction of HPLC‐purified DNA‐stabilized silver nanoclusters (DNA‐AgNCs) is a powerful tool to determine the charge and structure of the encapsulated AgNC. Such information is not only relevant to design new DNA‐AgNCs with tailored properties, but it is also important for bio‐conjugation experiments and is essential for electronic structure calculations. Here, the efforts to determine the structure of a HPLC‐purified green emissive DNA‐AgNC are presented. Unfortunately, the original DNA‐AgNC, known to have four valence electrons, could not be crystallized. By modifying the stabilizing DNA sequence, while maintaining the original spectroscopic properties, several mutants could be successfully crystallized, and for one of them, single crystal X‐ray diffraction data provided insight into the silver positions. While the DNA conformation is not resolved, the described approach provides valuable insight into the class of green and dual emissive DNA‐AgNCs with four valence electrons. These results constitute a roadmap on how to improve crystallization and crystal quality for X‐ray diffraction measurements.
Ni‐Doped RuPt Nanoalloy on Acid‐Treated Carbon for pH‐Universal Hydrogen Evolution Reaction
Authors: Huynh Tai Thien , Mai Vo Thi Tuyet , Nguyen Anh Quoc Khuong , Pham Hau Quoc 
Published: November 2023

AbstractAlthough alloying Pt with Ru has recently been reported as an advanced catalyst for the hydrogen evolution reaction (HER), their electrocatalytic performance and high cost are major limitations of the electrochemical water‐splitting technology. Therefore, the study herein reports a doping strategy of Ni atoms into the RuPt lattice that not only further reduces the noble metal content but also enhances the overall HER efficiency via the formed synergistic effects. With boosting reaction kinetics, the as‐made ternary alloy catalyst exhibits improved HER efficiency, achieving a low overpotential/Tafel slope of 22.14 mV/23.92 mV dec−1 in the 0.5 m H2SO4 and 46.52 mV/37.82 mV dec−1 in the 1.0 m KOH electrolyte. Furthermore, the NiRuPt/Activated XC‐72 shows high TOFs (4.13 H2 s−1 at 50 mV/3.88 H2 s−1 at 100 mV in acidic/alkaline electrolyte) and great long‐term stability. This study suggests that the development of Pt‐based ternary nanoalloys is an attractive strategy for using low‐precious metal‐content catalysts for electrochemical energy‐related technologies.
High‐Voltage Instability of Vinylene Carbonate (VC): Impact of Formed Poly‐VC on Interphases and Toxicity
Authors: Kubot Maximilian , Balke Lisa , Scholz Johannes , Wiemers‐Meyer Simon , Karst Uwe , Hayen Heiko , Hur Hyuck , Winter Martin , Kasnatscheew Johannes , Nowak Sascha 
Published: November 2023

Abstract
Full exhaustion in specific energy/energy density of state‐of‐the‐art LiNixCoyMnzO2 (NCM)‐based Li‐ion batteries (LIB) is currently limited for reasons of NCM stability by upper cut‐off voltages (UCV) below 4.3 V. At higher UCV, structural decomposition triggers electrode crosstalk in the course of enhanced transition metal dissolution and leads to severe specific capacity/energy fade; in the worst case to a sudden death phenomenon (roll‐over failure). The additive lithium difluorophosphate (LiDFP) is known to suppress this by scavenging dissolved metals, but at the cost of enhanced toxicity due to the formation of organofluorophosphates (OFPs). Addition of film‐forming electrolyte additives like vinylene carbonate (VC) can intrinsically decrease OFP formation in thermally aged LiDFP‐containing electrolytes, though the benefit of this dual‐additive approach can be questioned at higher UCVs. In this work, VC is shown to decrease the formation of potentially toxic OFPs within the electrolyte during cycling at conventional UCVs but triggers OFP formation at higher UCVs. The electrolyte contains soluble VC‐polymerization products. These products are formed at the cathode during VC oxidation (and are found within the cathode electrolyte interphase (CEI), suggesting an OFP electrode crosstalk of VC decomposition species, as the OFP‐precursor molecules are shown to be formed at the anode.
The efficacy of beeswax in extending frying life of sunflower oil and storage stability of fried potato chips
Authors: Tajer Abdolhadi , Ozdemir Salih 
Published: November 2023

AbstractThis study was performed to investigate the impact of adding beeswax to sunflower oil on its frying life and the oxidative stability of the fried potato chips during storage. In this study, sunflower oil and its oleogels containing 2, 4, and 6/100 g(w/w) of beeswax were used in order to fry potato chips for 4 h each day for 4 days consecutively. Samples fried in sunflower oil absorbed the highest amount (37.0%) of oil compared to the lowest (32.9%) in 2% oleogel. The addition of beeswax did not negatively affect the color, texture, and sensory quality of potato chips. Based on the analysis of total polar components, changes in fatty acid composition, and p‐anisidine evaluation, the findings of this study indicate that the utilization of beeswax‐sunflower oil oleogel, particularly the 6% oleogel, may offer enhanced frying stability compared to sunflower oil. Moreover, chemical analyses of the potato chips stored for 30 days revealed that the control sample contained highest level of secondary oxidation products compared to the oleogels, indicating that fried potato chips in oleogels were more resistant to oxidation during storage. Therefore, beeswax can be considered as a natural preservative that improves the shelf life of fried potato chips as well as the frying stability of sunflower oil.
Risk of Hypertensive Disorders and Preterm Birth in Pregnant Women With Systemic Vasculitides: A Nationwide Population‐Based Cohort Study
Authors: Mettler Camille , Beeker Nathanael , Collier Mathis , Le Guern Véronique , Terrier Benjamin , Chouchana Laurent 
Published: November 2023

ObjectiveEven though systemic vasculitides (SVs) affect primarily patients over 50 years of age, they can occur among women of childbearing age. Preterm birth (PTB) and hypertensive disorders are frequent complications of pregnancy in SVs. This study aims to evaluate the risk of hypertensive disorders and PTB among pregnant women with SVs, and to identify associated risk factors.MethodUsing the French health insurance data warehouse, we conducted a nationwide cohort study including all pregnancies between 2013 and 2018 in women with SVs. Theses pregnancies were matched to pregnancies among women without SVs. We estimated risk of hypertensive disorders and PTB risk during pregnancy among women with SVs and investigated associated risk factors using a nested case‐control design.ResultsAmong 3,155,723 pregnancies, we identified 646 pregnancies in women with SVs, matched to 3,230 controls. SVs were significantly associated with hypertensive disorders (odds ratio [OR] 1.7, 95% confidence interval [95% CI] 1.3–2.2) and PTB (OR 1.8, 95% CI 1.4–2.3). Chronic renal failure before pregnancy, history of or treated arterial hypertension, the occurrence of vasculitides flare during pregnancy, and the subgroup of SVs were independently associated with the occurrence of hypertensive disorders. Maternal age at delivery, chronic renal failure before conception, and the occurrence of vasculitides flare during pregnancy were independently associated with the occurrence of PTB.ConclusionAbout one of seven pregnancies in women with SVs is associated with hypertensive disorders or preterm birth. The occurrence of vasculitides flare was associated with these complications. Our findings support the importance of prepregnancy counseling to ensure disease stability.image
Study on the Mechanism of Rapid Oil‐Water Separation by a Fe3O4@PMMA@PDMS Intelligent Superhydrophobic Micro/Nanorobot
Authors: Wang Zuoliang , Qu Guangfei , Ren Yuanchuan , Chen Xiuping , Wang Jun , Lu Ping , Cheng Minhua , Chu Xiaomei , Yuan Yongheng 
Published: November 2023

AbstractWe prepared an environmentally friendly intelligent Fe3O4@PMMA@PDMS superhydrophobic oil‐absorbing material with simple process and excellent performance, and investigated the effects of different particle sizes of Fe3O4, different concentrations of PDMS, and different heating times on the superhydrophobicity of the coating. The best performance of the coating was achieved at a particle size combination of 20/500 nm for Fe3O4, a PDMS to Fe3O4@PMMA mass ratio of 6 : 1, and a heating time of 2 min at 400 °C. H2‐SPSS coating not only has excellent superhydrophobicity, abrasion resistance, self‐cleaning property, and chemical corrosion, but also has good flux and efficiency for separating oil‐water mixture, with fluxes of 40,540, 32,432, and 37,027 Lm−2h−1 for trichloromethane, dichloromethane and bromoethane, respectively, and separation efficiencies of 99.78 %, 99.74 % and 99.73 %, respectively. In addition, we also prepared a superhydrophobic magnetic polyurethane (SPPU) sponge using Fe3O4@PMMA@PDMS, which not only has a good oil absorption capacity of 18–44 g/g for different oil substances, it can also move directionally by magnet attraction and absorb oil along a fixed path. Under the control of the magnet, SPPU completes the whole oil absorption process in only 4 s, showing excellent oil absorption and intelligence.
Bioanalytical liquid chromatography–tandem mass spectrometry method development and validation for quantification of lurasidone in rat plasma using ion pairing agent
Authors: Rajadhyaksha Madhura , Londhe Vaishali 
Published: November 2023

AbstractA bioanalytical method was developed and validated for determining lurasidone (LUR) in rat plasma. The analyte and internal standard were extracted from rat plasma using a liquid–liquid extraction method. The mobile phase consisted of methanol, acetonitrile and water, with an ion pairing agent, 0.1% heptafluorobutyric acid, added to minimise the matrix effect. The detection was achieved using a tandem mass spectrometer (API 2000) in positive ion multiple reaction monitoring mode. All parameters were validated, including selectivity, specificity, carry‐over effect, linearity, precision, accuracy, matrix effect, sensitivity and stability. The linearity range was from 5.0 to 1200.0 ng/mL with a correlation coefficient of >0.99. The accuracy ranged from 100.00% to 110.22% across the quality control range. The mean absolute recovery from matrix samples for LUR and the internal standard was found to be 68.46% and 67.25%, respectively, and the relative recovery was found to be 73.89% and 77.44%, respectively. This method can determine LUR concentrations in rat plasma samples up to 12 h after oral administration, aiding in LUR pharmacokinetic (PK) investigations in rats. The method's reproducibility on a conventional LC–MS/MS system and a shorter run time of 3.0 min make it an appealing bioanalytical method for quantifying LUR in PK studies.
Carbon emissions, fracking, and firm value of U.S. oil and gas firms
Authors: Mollick André Varella , Haidar Md Ismail 
Published: November 2023

AbstractWe examine in this paper how firm value (market‐to‐book ratio, MTB) of U.S. oil and gas sector firms from 2010 to 2020 responds to carbon emissions intensity measures. We investigate three measures comprising total carbon emissions relative to assets, to market value of equity, and to net property, plant, and equipment. Our dynamic panel data approach separates the 82 firms into 35 fracking and 47 non‐fracking companies to address features underlying firm financing during the shale oil revolution. Concerned investors about the companies' large carbon emissions may have pulled out of the sector. These companies may also have overleveraged when expanding into new technologies of oil production or kept larger cash flow ratios. We report lower average carbon emissions for fracking firms, together with the larger size of fracking techniques: mean of assets of $46 billion for fracking versus $12 billion for non‐fracking companies. Using fixed‐effects and system generalized methods of moments (SGMM) models, we find that carbon emissions decrease MTB of fracking firms more than non‐fracking firms. Our dynamic panel approach provides a more accurate measure of the real effect of carbon emissions that is very robust to Tobin's q as alternative measure of firm value.
Nickel modified TiO2/C nanodisks with defective and near‐amorphous structure for high‐performance sodium‐ion batteries
Authors: Zhang Daijie , Xu Hui 
Published: November 2023

AbstractLow‐cost sodium‐ion batteries (SIBs) are the star products in grid‐scale energy storage applications. Finding befitting anode materials is crucial to the advancement of SIBs. In this study, a novel two‐dimension (2D) nanostructured anode material composed of TiO2/C nanodisks and Ni nanoparticles that were synthesized by a facile metal‐organic frameworks derived method is reported. By introducing divalent Ni2+ ions in the synthesis process, TiO2/C microblocks were successfully transformed into the desirable 2D nanodisks, enabling the active materials to be more efficiently and fully utilized due to short diffusion path and substantive exposed active sites. Another important role of Ni2+ ions is as a doping source for TiO2, resulting in the formation of a defective and near‐amorphous TiO2/C structure, which aids in improving the kinetics. In addition, some Ni nanoparticles formed and attached to the surface of the TiO2/C nanodisks, which not only act as conductive bridges to make all the nanodisks electrically active but also act as pillars to prevent them from stacking. This unique 2D nanostructured anode material manifests high reversible capacities, excellent cycle performance, and impressive rate capability. This work provides a new means for the controllable synthesis of 2D nanostructured materials for energy storage applications.
Pepper, just show me the way! How robotic shopping assistants should look and act
Authors: Fukawa Nobuyuki , (Sandy) Huang Yu‐Shan , Babin Barry J. 
Published: November 2023

AbstractArtificial intelligence enables modern robots to serve as service and sales assistants. Today's robotic shopping assistants (RSAs) can appear either humanoid or non‐humanoid and possess utilitarian and/or hedonic attributes. However, many questions remain unexplored regarding an effective customer‐centric RSA design. Do customers prefer a humanoid or non‐humanoid RSA with hedonic or utilitarian attributes? To answer those questions, the research deploys a mixed‐method approach involving a survey of customers who have interacted with the Pepper Robot, a humanoid robot (Study 1), and follow‐up experiments examining customer responses to a humanoid/non‐humanoid RSA with hedonic/utilitarian attributes (Studies 2 and 3). The research employs an innovative approach that analyzes both unstructured and structured data simultaneously. Study results suggest that customers prefer humanoid RSAs with utilitarian attributes over those with hedonic attributes. The research contributes to the literature by proposing hedonic (vs. utilitarian) attributes of RSAs as new drivers of anthropomorphic perceptions.
Ring‐Opening of 1,3‐Imidazole Based Mesoionic Carbenes (iMICs) and Ring‐Closing Clicks: Facile Access to iMIC‐Compounds
Authors: Merschel Arne , Vishnevskiy Yury V. , Neumann Beate , Stammler Hans‐Georg , Ghadwal Rajendra S. 
Published: November 2023

AbstractHerein, ring‐opening of mesoionic carbenes (iMICs) (iMIC=[ArC{N(Dipp)}2C(SiMe3)C:) (Dipp=2,6‐iPr2C6H3, Ar=Ph, 4‐Me2NC6H4 or 4‐PhC6H4) based on an 1,3‐imidazole scaffold to yield N‐ethynylformimidamide (eFIM) derivatives as crystalline solids (eFIM={(Dipp)N=C(Ar)N(Dipp)}C≡CSiMe3) is reported. eFIMs are thermally stable under inert gas atmosphere and show moderate air stability (t1/2=3 h for Ar=Ph). eFIMs are excellent surrogates of iMICs, which generally have a limited shelf‐life, and readily undergo ring‐closing click reactions with a variety of main‐group as well as transition metal Lewis acids to form hitherto challenging iMIC‐compounds in good to excellent yields. In addition to the relevance of eFIMs in the synthesis of iMIC‐compounds, quantification of the stereoelectronic properties of a representative iMIC (Ar=Ph) by experimental and theoretical methods suggests remarkably σ‐donor property and steric profile of these new ligand sets.
Expression of EGFR, PD‐L1, and the mismatch repair proteins before and following therapy in malignant serous effusions with metastatic high‐grade serous tubo‐ovarian carcinoma
Authors: Nikas Ilias P. , Park Soo‐Young , Song Min Ji , Lee Cheol , Ryu Han Suk 
Published: November 2023

AbstractAimTo compare the immunochemical expression of EGFR, PD‐L1, and the mismatch repair (MMR) proteins MLH1, PMS2, MSH2, and MSH6 between matched malignant effusions obtained before and following the administration of chemotherapy in patients with high‐grade serous tubo‐ovarian carcinoma (HGSC).MethodsIn the enrolled HGSCs, matched formalin‐fixed and paraffin‐embedded cell blocks (CBs) from effusions sampled before (treatment‐naïve patients) and during recurrence (following chemotherapy administration), in addition to their matched HGSC tissues obtained from the ovaries at initial diagnosis (treatment‐naïve patients), were subjected to EGFR, PD‐L1, and MMR immunochemical analysis.ResultsEGFR was more often overexpressed in effusions obtained after chemotherapy administration compared to both effusions (100% vs. 57.1%) and their matched tubo‐ovarian tumors (100% vs. 7.1%) from treatment‐naïve patients, respectively. EGFR immunochemistry was concordant in just 9.1% of the effusions sampled during recurrence and their paired ovarian samples before recurrence. Whereas all HGSC treatment‐naïve samples (ovarian lesions and effusions) were PD‐L1 negative, 3/11 (27.3%) malignant effusions obtained during recurrence showed PD‐L1 overexpression. Lastly, none of the tested HGSC samples exhibited MMR deficiency.ConclusionMeasuring biomarkers using CBs from malignant effusions may provide clinicians with significant information related to HGSC prognosis and therapy selection, especially in patients with resistance to chemotherapy.