bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions between antiseizure medications and foods and drinks: A systematic review
Authors: Asadi‐Pooya Ali A. , Johannessen Landmark Cecilie , Mirzaei Damabi Nafiseh , Fazelian Khatereh 
Published: February 2024

AbstractAntiseizure medications (ASMs) constitute the principal of treatment for patients with epilepsy, where long‐term treatment is usually necessary. The purpose of this systematic review is to provide practical and useful information regarding various aspects of the interactions between ASMs and foods and drinks. MEDLINE and ScienceDirect, from the inception to July 15, 2023, were searched for related publications. In both electronic databases, the following search strategy was applied, and the following keywords were used (in title/abstract): “food OR drink” AND “antiepileptic OR antiseizure.” The primary search yielded 738 studies. After implementing our inclusion and exclusion criteria, we could identify 19 studies on the issue of interest for our endeavor. Four studies were identified in the recheck process and not by the primary search. All studies provided low level of evidence. Interactions between foods and ASMs are a common phenomenon. Many factors may play a role for such an interaction to come to play; these include drug properties, administration route, and administration schedule, among others. Drugs‐foods (‐drinks) interactions may change the drug exposure or plasma levels of drugs (e.g., grapefruit juice increases carbamazepine concentrations and the bioavailability of cannabidiol is increased 4–5 folds with concomitant intake of fat‐rich food); this may require dosage adjustments. Interactions between ASMs and foods and drinks may be important. This should be taken seriously into consideration when consulting patients and their caregivers about ASMs. Future well‐designed investigations should explore the specific interactions between foods (and drinks) and ASMs to clarify whether they are clinically important.Plain Language SummaryInteractions between antiseizure medications and foods and drinks may be important. This should be taken into consideration in patients with epilepsy.
Testing and refinement of elemental proxies in tropical lakes from the Indian subcontinent
Authors: Mishra Praveen Kumar , Jehangir Arshid , Yousuf Abdul Rehman , Prasad Sushma , Anoop Ambili , Gaye Birgit 
Published: February 2024

AbstractThe conventional approach of using modern values of lake hydrochemistry and sediment composition as key parameters for identifying proxies for environmental reconstruction is complicated by regional climate, catchment geology, lake morphometry and anthropogenic input. In contrast to modern studies from lakes in the north‐temperate regions, reliable proxy indicators for past environmental change from tropical lake systems are still lacking. In this study, we compare new surface geochemical and mineralogical data from the Manasbal Lake, Kashmir (India), with other lakes situated in climatically and geomorphologically distinct regimes with varying degrees of pollution (Tso Moriri in north‐western Himalaya and Lonar in central India). We characterise external (e.g., geology and weathering), internal (e.g., lake water mixing and evaporation) factors and human activities influencing sediment composition and spatial distribution of proxies in each of these lakes to evaluate the usefulness of some of the commonly used proxies, as well as ascertain conditions where they might be applicable. Our results show that (i) morphometric parameters (such as lake size, water depth and catchment vs. lake area) variably influence the spatial distribution of sediments and proxies on the lake bottom highlighting the limitations of using single cores for long‐term palaeoclimate reconstruction; (ii) hydrochemical proxies (such as Na+/Na++Ca2+and Mg/Ca) can delineate endogenic (Lonar and Tso Moriri lakes) versus allogenic (Manasbal Lake) influence on modern sediment characteristics; (iii) the compilation of heavy metal data (e.g., Fe, Zn, Mn, Cr and Ni) from all three lake basins with varying degrees of pollution highlights the limitations of using them to characterise weathering conditions in these basins; and (iv) human impact must be precluded before using the most promising endogenic minerals (calcite, aragonite, gypsum and pyrite) as palaeoenvironmental/palaeoclimate indicators.
Moving least‐squares aided finite element method: A powerful means to predict flow fields in the presence of a solid part
Authors: Mostafaiyan Mehdi , Wießner Sven , Heinrich Gert 
Published: February 2024

AbstractWith the assistance of the moving least‐squares (MLS) interpolation functions, a two‐dimensional finite element code is developed to consider the effects of a stationary or moving solid body in a flow domain. At the same time, the mesh or grid is independent of the shape of the solid body. We achieve this goal in two steps. In the first step, we use MLS interpolants to enhance the pressure (P) and velocity (V) shape functions. By this means, we capture different discontinuities in a flow domain. In our previous publications, we have named this technique the PVMLS method (pressure and velocity shape functions enhanced by the MLS interpolants) and described it thoroughly. In the second step, we modify the PVMLS method (the M‐PVMLS method) to consider the effect of a solid part(s) in a flow domain. To evaluate the new method's performance, we compare the results of the M‐PVMLS method with a finite element code that uses boundary‐fitted meshes.
Immunosuppression and cancer risk in kidney transplant recipients: A retrospective cohort study
Authors: Sapir‐Pichhadze Ruth , Laprise Claudie , Beauchamp Marie‐Eve , Kaouache Mohammed , Zhang Xun , Della Vecchia Alexia , Azoulay Laurent , Franco Eduardo L. , Abrahamowicz Michal , Nicolau Belinda 
Published: February 2024

AbstractWe assessed whether contemporary immunosuppression agents were associated with cancer among kidney transplant recipients (KTR), and if this association varied by age and sex. We studied a retrospective province‐wide cohort of primary KTR (1997–2016). Employing multivariable Cox models, we estimated associations of cumulative doses of prednisone, mycophenolate and tacrolimus administered over the past 10 years, lagged by 2 years, with the incidence of primary malignant neoplasms (PMN). We assessed interactions with age and sex. To assess the impact of exposure recency, we used weighted cumulative exposure (WCE) modeling. Among 1064 KTR, 108 (10.2%) developed PMN over median follow‐up of 73 months (interquartile range: 32–120). Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of 0.96 (0.64–1.43), 1.34 (0.96–1.86), and 1.06 (0.88–1.29) were estimated for cumulative daily doses of prednisone (5 mg), mycophenolate (1000 mg), and tacrolimus (2 mg) administered continuously over the past 10 years, respectively. PMN risk associated with cumulative tacrolimus exposure was modified by age (interaction p = .035) and was more pronounced in 15‐year and 30‐year‐old KTR (aHRs of 1.57 [1.08–2.28] and 1.31 [1.03–1.66], respectively) in comparison to older KTR. PMN risk increase associated with higher cumulative mycophenolate dose was more pronounced in females (aHR = 1.86 [1.15–3.00]) than in males (aHR = 1.16 [0.74–1.81]; interaction p = .131). WCE analyses suggested increased PMN risk the higher the mycophenolate doses taken 5–10 years ago. A trend toward increased PMN risk with long‐term mycophenolate exposure, particularly in females, and more pronounced risk with long‐term tacrolimus exposure in younger KTR, identify opportunities for tailored immunosuppression to mitigate cancer risk.
Sonographic appearance of focal liver lesions and likelihood of hepatocellular carcinoma in adult Thais with chronic hepatitis B virus infection
Authors: Suttivanich Sarana , Soonklang Kamonwan , Hiranrat Pantajaree , Siripongsakun Surachate 
Published: February 2024

AbstractPurposeThe objective of our study was to study and compare the sonographic findings of hepatocellular carcinoma (HCC) and benign liver lesions, and apply these to an HCC surveillance program in patient with chronic hepatitis B virus (HBV).MethodsSonographic findings of HCC and benign liver lesions were retrospectively reviewed following diagnosis based on either computer tomography or magnetic resonance imaging from July 2010 to December 2020. Multiple sonographic features were analyzed, including internal echogenicity, rim characteristics, and posterior acoustic enhancement. Associations between sonographic characteristics and HCC were assessed using uni‐ and multi‐variate logistic regression analyses.ResultsOf the focal liver lesions in 337 chronic HBV patients, there were 25 HCC and 410 benign lesions, with median sizes of 1.6 and 1.0 cm, respectively. Three ultrasound patterns, homogeneous hypoechogenicity, heterogeneous echogenicity, and hypoechoic rims were more frequently found in HCC than in benign lesions. Moreover, the hypoechoic rim feature was the only sonographic pattern independently associated with HCC (Odds ratio, 68.05; 95% confidence interval, 7.37–628.10; p‐values < 0.001). In a subgroup analysis of the lesions sized 2 cm or smaller, no sonographic findings were associated with HCC.ConclusionA hypoechoic rim was a sonographic feature independently associated with HCC. These findings may aid in improving HCC detection and guiding management during HCC screening and surveillance with ultrasound.
Progression from the mean: Cultivating instructors' unique trajectories of practice using educational technology
Authors: Koretsky Milo D. , Nolen Susan Bobbitt , Galisky John , Auby Harpreet , Grundy Lorena S. 
Published: February 2024

AbstractBackgroundIn taking up educational technology tools and student‐centered instructional practice, there is consensus that instructors consider the unique aspects of their instructional context. However, tool adoption success is often framed narrowly by numerical uptake rates or by conformity with non‐negotiable components.PurposeWe pursue an alternative ecosystems framing which posits that variability among contexts is fundamental to understanding instructors' uptake of instructional tools and the ways their teaching trajectories develop over time.Design/MethodThrough a multiple‐case study approach using interviews, usage data, surveys, and records of community meetings, we examine 12 instructors' trajectories to illustrate the dynamic uptake of a technology tool.ResultsCross‐case analysis found that instructors' trajectories are tool‐mediated and community‐mediated. We present five cases in detail. Two foreground ways that instructors gained insight into student learning from student responses in the tool. Two illustrate the role played by the project's Community of Practice (CoP), an extra‐institutional support for deepening practice. The final case illustrates the complexity of an evolving instructional ecosystem and its role in instructors' satisfaction and continued use.ConclusionsUse of the educational technology tool perturbed ecosystems and supported instructors' evolving trajectories through mediation of instructor and student activity. Instructors' goals guided initial uptake, but both goals and practice were adapted using information from interactions with the tool and the CoP and changes in instructional contexts. The study confirms the need to understand the complexity of the uptake of innovations and illustrates opportunities for educators, developers, and administrators to enhance uptake and support diversity goals.
Codon usage bias of human papillomavirus type 33 and 58: A comprehensive analysis
Authors: Tan Xiaochun , Xie Yucheng , Jiang Chaoyue , Li Hui , Lu Yu , Shen Weifeng , Chen Jing 
Published: February 2024

AbstractCervical cancer is closely linked to specific strains of human papillomavirus (HPV), notably HPV‐33 and HPV‐58, which exhibit a significant prevalence among women in China. Nevertheless, the codon usage bias in HPV‐33 and HPV‐58 is not well comprehended. The objective of this research is to analyze the codon usage patterns HPV‐33 and HPV‐58, pinpoint the primary factors that influence codon preference. The overall preference for codon usage in two HPV genotypes is not significant. Both HPV genotypes exhibit a preference for codons that end with A/U. The GC3 content for HPV‐33 is 25.43% ± 0.35%, and for HPV‐58, it is 29.44% ± 0.57%. Out of the 26 favored codons in HPV‐33 and HPV‐58 (relative synonymous codon usage (RSCU) > 1), 25 conclude with A/U. Principal component analysis (PCA) shows a tight clustering of the entire genome sequences of HPV‐33 and HPV‐58, suggesting a similarity in their RSCU preferences. Moreover, an examination of dinucleotide abundance indicated that translation selection influenced the development of a distinctive dinucleotide usage pattern in HPV‐33 and HPV‐58. Additionally, a combined analysis involving an effective number of codons plot, parity rule 2, and neutrality analysis demonstrated that, for HPV‐33 and HPV‐58, the primary determinant influencing codon usage preference is natural selection. HPV‐33 and HPV‐58 exhibit a restricted set of favored codons in common with humans, potentially mitigating competition for translation resources. Our discoveries could provide valuable perspectives on the evolutionary patterns and codon usage preferences of HPV‐33 and HPV‐58 viruses, contributing to the development and application of relevant HPV subtype vaccines.
Is it “all in the bag?” Multidisciplinary perspectives on ostomy surgery in pediatric IBD across the ImproveCareNow network
Authors: David Jennie G. , Dotson Jennifer , Mackner Laura ,   ImproveCareNow Learning Health System
Published: February 2024

AbstractObjectivesPediatric inflammatory bowel disease (IBD) is a chronic illness with various treatments, including ostomy surgery. Ostomy‐related medical decision‐making (MDM) is complex for multidisciplinary healthcare professionals (HCPs). This study sought to understand national multidisciplinary HCPs' perceptions about pediatric IBD ostomy surgery in the United States.MethodsThis cross‐sectional REDCap survey recruited HCPs in pediatric IBD HCP roles from the ImproveCareNow (ICN) Learning Health System. The survey gathered data on, (1) demographics, (2) participants' perspectives on patients/families' ostomy perceptions, (3) participants' own perspectives on ostomies, and (4) participants' perspectives on multidisciplinary collaboration in ostomy surgery.ResultsParticipants (n = 69, across n = 30 American ICN sites) were 84% White, 62% female, and 54% gastroenterologists. In reflecting on patients/families' perceptions, participants endorsed most (86%) view ostomies as a “failure,” various psychosocial concerns (e.g., 97% endorsed body image concerns), and most (81%) have moderate to significant stigma about ostomies. In reflecting on their own perceptions, nearly half (44%) endorsed some to moderate stigma about ostomies and felt ostomy discussions were difficult when families had negative perceptions (88%). Over half (54%) endorsed currently having multidisciplinary care for pediatric IBD surgery. Most (70%) endorsed variability in the amount and/or quality of multidisciplinary collaboration.ConclusionMDM related to pediatric IBD ostomy surgery presents nuanced clinical complexities for HCPs. This work underscores interest in multidisciplinary care, notable ostomy‐related psychosocial needs, and ostomy‐related stigma. Future work should develop systematic approaches to multidisciplinary pediatric IBD ostomy care, bolster psychosocial support, and evaluate how systematic care may impact psychosocial, and healthcare utilization outcomes.
Sulfur: Long‐term outlook for a critical element for surfactant production
Authors: Grady Brian P. 
Published: February 2024

AbstractSulfur is a key element in most anionic surfactants. About 75% of sulfur currently is generated as a waste byproduct of petroleum refining, while most of the remainder is generated as a waste byproduct of natural gas refining. Assuming the world's fossil fuel use decreases in the future, what will happen with sulfur‐containing surfactants? Three possible alternatives are explored. First, alternate sources of sulfur could replace sulfur from fossil fuel. Second, surfactants that do not contain sulfur could replace those that contain sulfur. Third, other industries could replace sulfur in their products, while sulfur remains in surfactants. Each of these will be considered, and predictions will be made in terms of the likeliest outcomes.
Noninvasive Treatment of Venous Pulsatile Tinnitus with an Internal Jugular Vein Compression Collar
Authors: Succop Benjamin , Thompson Nicholas J. , Dedmon Matthew M. , Gelinne Aaron , Selleck Anne , Reed Samuel , Sindelar MAJ Brian D. 
Published: February 2024

ObjectiveThe study was conducted to evaluate the safety and efficacy of mild internal jugular (IJV) compression via an FDA approved compression collar for symptomatic treatment of venous pulsatile tinnitus.MethodsThis is a prospective study that recruited 20 adult patients with venous pulsatile tinnitus. Participants completed the Tinnitus Handicap Inventory (THI), were fitted with the collar, and rated symptom intensity on a 10‐point tinnitus intensity scale before and during collar use. Once weekly for 4 weeks, they answered a survey quantifying days used, average tinnitus intensity before and after wearing the collar each day of use, and any safety concerns. Lastly, they completed an exit interview. The primary outcome was symptomatic relief, with secondary outcomes of safety, effect of treatment setting, effect of time, and quality of life assessed via nonparametric testing.Results18 participants completed the study, and 276 paired daily before use/during use intensity scores were submitted. The median symptom intensity without the collar was 6 (IQR 4, 7), whereas with the collar it was 3 (IQR 2, 5), for a median symptomatic relief of 50%. The collar had a significant effect in reducing symptom intensity (p < 0.0001) and burden of illness via the THI (p < 0.0001). There was no effect of setting, frequency, or time on symptomatic relief with the collar. There were no adverse safety events reported aside from minor discomfort upon initial application.ConclusionsVenous compression collars offer acute symptom relief for patients with venous pulsatile tinnitus. Further study is needed to assess safety and efficacy of longitudinal use.Level of Evidence4 Laryngoscope, 134:3342–3348, 2024
Plasma sphingolipids in patients with sickle cell disease: Multiple‐site vaso‐occlusive crises could be associated with lower sphingolipid levels
Authors: Alp Gokce , Oztas Yesim , Yalcinkaya Ahmet , Ozel Selinay , Yildirim Nazim , Unal Selma 
Published: February 2024

AbstractAlthough sickle cell disease (SCD) and its manifestations have been associated with various lipid alterations, there are a few studies exploring the impact of sphingolipids in SCD. In this study, we determined plasma ceramide (Cer) and sphingomyelin (CerPCho) species and investigated their association with the crisis in SCD. SCD patients (N = 27) suffering from vaso‐occlusive crisis (VOC) or acute chest syndrome (ACS) were involved in this study. Blood samples were drawn at crisis and later at steady state periods. Clinical history, white blood cell count (WBC), C‐reactive protein and lactate dehydrogenase (LDH) levels were recorded. 16:0, 18:0, 20:0, 22:0 Cer and 16:0, 18:0, 24:0 CerPCho were measured via LC–MS/MS. All measured Cer and CerPCho levels of SCD patients at crisis and steady‐state were found to be similar. Inflammation‐related parameters were significantly higher in patients with ACS compared to single‐site VOC. Patients with multiple‐site VOC were found to have significantly lower sphingolipid levels compared with those with single‐site VOC, at crisis (16, 18, 24 CerPCho and 18, 22 Cer) and at steady‐state (24:0 CerPCho and 18 Cer). Our results show that sphingolipid levels in SCD patients are similar during crisis and at steady state. However, lower sphingolipid levels appear to be associated with the development of multiple‐site VOC. Since the differences were observed at both crisis and steady‐state, sphingolipid level could be an underlying factor associated with crisis characteristics in patients with SCD.
Multifrequency and Multimode Topological Waveguides in a Stampfli‐Triangle Photonic Crystal with Large Valley Chern Numbers
Authors: Yan Bei , Peng Yiwei , Xie Jianlan , Peng Yuchen , Shi Aoqian , Li Hang , Gao Feng , Peng Peng , Jiang Jiapei , Liu Jianjun , Gao Fei , Wen Shuangchun 
Published: February 2024

AbstractThe multifrequency quantum valley Hall effect (QVHE) has been realized to significantly improve the transmission capacity of topological waveguides, and the multimode QVHE with a large valley Chern number has been realized to increase the mode density of topological waveguides. However, multifrequency and multimode QVHEs have not been realized simultaneously. In this work, using tight‐binding model calculations and numerical simulations, a valley photonic crystal (VPC) consisting of a Stampfli‐triangle photonic crystal is constructed, and its multiple degeneracies in the low‐frequency and high‐frequency bands split simultaneously to realize the QVHE with multiple topological edge states (TESs). The multifrequency and multimode topological transmission with two low‐frequency modes and four high‐frequency modes is realized by means of simulations and experiments through a Z‐shaped waveguide constructed using two VPCs with opposite valley Chern numbers to prove the realization of a large valley Chern number in the two frequency bands. The two low‐frequency modes are successfully distinguished with position‐dependent selective excitations, which experimentally demonstrate the occurrence of a large valley Chern number. A frequency‐dependent multimode beam splitter is theoretically proposed for high‐performance integrated photonic device applications. These results provide new ideas for high‐efficiency and high‐capacity optical transmission and communication devices and their integration; furthermore, they broaden the application range of TESs.
Impact of copycatting on the luxury manufacturer's distribution contracts in the e‐commerce era
Authors: Teng Yingying , Hou Pengwen , Xie Lei , Zhang Qian 
Published: February 2024

AbstractAlthough many luxury manufacturers have cooperated with e‐commerce platforms in reality, few studies have focused on the distribution contract options (retail or agency contracts) of luxury manufacturers in the presence of copycats. This paper demonstrates the effectiveness of different distribution contracts to prevent the entry of copycats and provides decision support for luxury manufacturers' anti‐copycat strategy. In particular, the e‐commerce platform can reduce the commission rate slightly to make the agency contract more effective in deterring copycats from entering the market. Finally, we find some results about consumer surplus and social welfare.