bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-operative screening of diabetic patients for heart rate variability and their hemodynamic responses during induction of general anaesthesia
Authors: Lakshminarasimhaiah Geetha , Dinesh Nithya , Kumar Arun , Musti Smita , Rao Ridhi , Khavas Ayesha Sabha 
Published: November 2023

: Cardiovascular autonomic neuropathy (CAN) is one of the least frequently diagnosed and the most clinically significant complications of Diabetes mellitus (DM). Impaired heart rate variability (HRV) is the earliest indicator of CAN. Peri-operative hemodynamic instability is a major concern during general anaesthesia (GA) in patients with autonomic dysfunction. Purpose of this study was to assess and compare the autonomic function using HRV in diabetic and non-diabetic patients pre-operatively and to study the haemodynamic responses of these patients during induction.: The primary objective was to assess and compare the autonomic function using HRV in diabetic and non-diabetic patients preoperatively. Secondary objective was to study hemodynamic responses of these patients during induction of GA.: We included 68 patients (34 diabetics- group D and 34 non-diabetics- group N) aged between 30 to 65 years, with American society of anaesthesiologists (ASA) physical status 1 and 2 undergoing elective surgeries under GA. All the eligible patients underwent HRV evaluation for 10 minutes on the previous day of surgery and the time & frequency domain variables were evaluated. The hemodynamic parameters were recorded at pre-induction, post-induction, post-intubation and for every 3 minutes thereafter for 15 minutes and analysed.: The diabetics had a significantly lower total power (TP) with p-value 0.003. The post- induction mean arterial pressures (MAP) were comparatively lower in diabetics and the difference was significant at 12 minutes post intubation (p= 0.04). The lower trends in heart rate (HR) were comparatively more in diabetics rather than non-diabetics (p= 0.06) and the ephedrine usage was also higher in diabetics (p= 0.07). The measurement of HRV is a simple tool to evaluate the peri-operative risks in patients with suspected cardiovascular autonomic neuropathy.
A randomized double blind study to evaluate the effect of nebulized dexmedetomidine on the haemodynamic response to laryngoscopy – Intubation and intubation conditions
Authors: Paul Neenu Susan , Abraham Valsamma , Liddle Dootika 
Published: November 2023

: A cardiovascular stress response is frequently brought on by direct laryngoscopy and intubation. It is widely known that the sympathetic adrenal stimulation elicited by mechanical stimulation to the upper respiratory tract is what causes the haemodynamic response during laryngoscopy and intubation. The study's goal was to assess the impact of preoperative dexmedetomidine nebulization on the patient's hemodynamic response to laryngoscopy- intubation and the intubation conditions.: The American Society of Anaesthesiologists (ASA) I & II adult patients, of either gender, undergoing elective surgeries requiring tracheal intubation were randomized to receive nebulized dexmedetomidine (Group D) or 0.9% saline (Group P), 30 minutes prior to the induction of anesthesia. This study was conducted in the department of anesthesia and critical care at the Christian Medical College in Ludhiana. Following laryngoscopy, the patient's heart rate and non-invasive systolic and diastolic blood pressure will be monitored for 10 minutes. The intubation conditions were noted during laryngoscopy.Total 100 patients with 50 in each group were included. At the time of laryngoscopy and after the intubation 1 min, 3 min,5 min, 7min and 10 min there were significantly lower trend in increasing HR, SBP, DBP and RPP in dexmedetomidine group versus saline. The intubation score representing conditions for intubation was significantly better in the dexmedetomidine group (P=0.013) than the saline group. There was no significant side effect noted (p=1.000). There was significant reduction in intraoperative analgesic and sedative requirement observed in dexmedetomidine groupOur study concluded that the nebulized dexmedetomidine attenuated haemodynamic response to laryngoscopy- intubation and provided better intubation conditions without significant side effects. We advise using nebulized dexmedetomidine pre-operatively for a surgical procedure requiring general anesthesia in order to reduce the haemodynamic response to intubation and to facilitate intubation conditions without experiencing any severe adverse effects.
Unexpected challenge: Proseal insertion and intubation complicated by undiagnosed aryepiglottic fold cyst
Authors: Sawhney Krishan Yogesh , Ahmad Sabih , Agarwal Aakash 
Published: November 2023

Airway management has always been the main stay of concern for all Anaesthetists especially when it is an undiagnosed difficult one. Our main stay of the article is to be prepared with all forms of equipment for any and all difficult airways, difficult airway can turn into a nightmare for any anaesthesiologist. Vallecular or aryepiglottic fold cysts are often asymptomatic and harmless as long as they do not cause airway narrowing.To discover a vallecular or aryepiglottic fold cyst after induction of anesthesia on direct laryngoscopy is a potentially life-threatening problem as it involves a challenge for the anaesthesiologist. This report describes the management of a patient with an asymptomatic vallecular cyst that was discovered during inability to ventilate after proseal insertion and visualised with laryngoscopy, prior to which the patient did not present with any airway symptoms even after anesthesia induction and muscle relaxant.
“Connect it down to the person”: Perspectives on Technology Adoption from Older Angelenos
Authors: Marnfeldt Kelly , Lomeli Sindy , Navarro Sheila Salinas , Estenson Lilly , Wilber Kate 
Published: November 2023

AbstractOlder adults can face multiple barriers to digital device adoption. To better understand these barriers and other influential factors of digital device use, we conducted focus groups and interviews with adults ages 60+ in collaboration with a non‐profit senior services organization in our large metropolitan area. The average age of participants (n=41) was 74.7 years (SD= 7.4 years). The sample included both Spanish‐speaking (n=21) and English‐speaking (n=20) participants. We used an immersion‐crystallization framework for analysis, engaging in extensive iterative cycles to add, remove and amend codes to identify four major themes: 1) facilitators and 2) barriers of technology usage and digital device uptake, 3) negative aspects of use, and 4) preferred learning methods for digital device training. We found that participants primarily used digital devices to connect with family and friends and cited this ability to connect as a key driver of both initial and continued use. Family members, prior work experience, and community resources were the main facilitators while lack of know‐how was a major barrier. Participants cited substantial concerns about online scams and fraud with frequent device use. Participants preferred hands‐on methods for digital device training and stressed the importance of patient instructors and repetition. To align with our findings, policies that support older adults in overcoming barriers to digital access should comprehensively address secondary barriers to digital adoption by providing ongoing individualized training and social support.
Method for calculating the individual hydrocarbon composition from the accumulated fractional composition of oil and condensate samples
Authors:   Azerbaijan State Oil and Industry University, Karimova Arifa Q. 
Published: November 2023

The composition of oils is the main source of information that enables the evaluation and modeling of their physical, thermal and chemical properties (including their critical properties) across a wide range of state parameters. The more comprehensively the composition of oils is analyzed, the more precise information is provided for calculations and problem-solving in the field of oilfield mechanics and related areas, such as the extraction, preparation, transportation, and processing of oils and their fractions. The principal constituents of oils are hydrocarbons. Oils contain hydrocarbons of three homologous series: paraffins, naphthenes and aromas. In oils, there may be hydrocarbons of a mixed composition containing both naphthenic and aromatic rings. In addition to hydrocarbons, oils also contain oxygen, sulfur, nitrogen and other constituents. These compounds are the primary elements of asphaltene-resinous substances (ARS) found in oil. They are characterized by high relative densities (often exceeding 1 g/cm3), dark coloration, and relative chemical instability when exposed to elevated temperatures, oxygen, adsorbents, etc. The composition of asphaltene-resinous substances encompasses a wide range of substances. The validity of the proposed technique is justified by the observation that the data of molecular weight, Watson characteristic factor, and experimental density calculated from molar compositions should align on the same surface with a high degree of correlation. In addition, the experimental and calculated values, in terms of molecular composition, of molecular weights should lie on a straight line passing through the origin of coordinates with a slope coefficient equal to unity and exhibit high degree of correlation.
Transporte en la logística verde: análisis bibliométrico
Authors: Palermo García Bersi , Salazar-Velázquez Ricardo 
Published: November 2023

El objetivo de este artículo es ofrecer una visión macroscópica del transporte en la logística verde mediante un análisis bibliométrico. Para dicho fin, la información se recopiló en Scopus con una muestra de 604 documentos de 2000 a 2022. Los datos se descargaron el 26 de marzo de 2023 y se utilizó Microsoft Excel® y VOSviewer®, para analizar la información. La palabra clave central fue "green logistics" con los filtros "transportation", "freight transportation", "freight transport", "transportation planning", "transportation system", "urban transportation" y "road transport". Entre los resultados más destacados, se observó que la temática planteada es reciente: los documentos se publicaron no hace más de 25 años. Además, solo 16 de los 72 países con publicaciones acaparan el 89.9 % del total, entre los cuales se destaca China. En cuanto a las áreas temáticas, se observó que las que más se abordan son Ingeniería, Ciencia de la Computación y Negocios Empresariales. Con respecto a las conclusiones, se puede señalar que se aplican los avances tecnológicos en computación y energía limpia a medida que surgen. También se concluye que los países con altos volúmenes de comercio internacional son los más interesados en hacer la logística de transporte más sostenible.
Códigos JEL: Q50
Recibido: 25/05/2023. Aceptado: 17/08/2023. Publicado: 10/10/2023.
Transient Stability Constrained Social Welfare Maximization with Demand Response in Smart Electrical Grid
Authors: Anand Shubham , Kumar Ravi , Humne Gaurang Ashok , MAITY SUPARNA , Chanda Sandip , Biswas Papun , De Abhinandan 
Published: November 2023

Abstract
The existing power grids round the globe are
getting converted to Smart Grid for promoting more
economic, reliable and sustainable operation and control in
presence of Renewable Energy Sources (RES). In
operational optimisation of the grid, not only intermittent
renewable generation poses difficulty but also an essential
resource Demand Response (DR) that is consumer
characteristics which is needed to balance generation and
demand,may introduce transient stability problems in the
grid. This is due to weather dependent variation of
generation of RES and subsequent controllable load
curtailment within very short duration of time. Though
transient stability problems cannot be predicted accurately
in time domain but if planned properly the grid may be
operated with substantial stability margin even before any
disturbance and subsequent perturbation of the operating
point, can happen. The pre-perturbation stability margin
helps in restoring the operating point of the system to stable
zone of operation during disturbance. Traditional OPF
algorithms of the grid like generation cost optimisation or
active power loss minimisation may not be sufficient to
provide a sustainable generation and demand schedule. This
work presents a few new OPF algorithmsfor Smart Grid
operational optimisation which takes care of rotor angle
stability along with the other important controllable like
generation cost, transmission line active power loss, voltage
profile, transmission line congestion and load curtailment
by producing optimal generation and load schedule without
conceding any limit violation. The most prominent result
was obtained from one of the proposed algorithms which
has been referred here as Transient stability constrained
Social Welfare optimisation as it causes benefit
simultaneously to GENCOs, TRANSCOs and DISCOs
adhering to transient stability constraint of the grid. This
work also validates the results of the optimisation (Optimal
generation and load schedule), demonstrating how the
proposed solution provides shorter time for rotor angle
restoration and comparatively lesser relative deviation of
rotor angles of the generators during a few cases of
simulated faults in MATLAB SIMULINK environment. For
the complexity of the objective function a differential
evolution modified quantum Particle Swarm Optimisation
(DEQPSO) algorithm has been proposed in this work.
PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site
Authors: Junior João Neif Antonio , Preto Daniel D'Almeida , Lazarini Maria Eduarda Zanatta Neder , de Lima Marcos Alves , Bonatelli Murilo , Berardinelli Gustavo Noriz , Silva Vinicius Duval da , Pinheiro Celine , Reis Rui Manuel , Cárcano Flavio Mavignier 
Published: November 2023

Abstract

BACKGROUND: Cancer of unknown primary site (CUP) is a heterogeneous group of tumors for which the origin remains unknown. Clinical outcomes might be influenced by regulatory processes in its microenvironment. Microsatellite instability (MSI) is a predictive biomarker for cancer immunotherapy and its status, as well as co-occurrence with PD-L1 expression, is poorly evaluated. We aim to evaluate the expression of PD-L1 and the status of MSI in CUP and their possible associations with clinical-pathological features.
METHODS: The combined positive score (CPS) PD-L1 expression was evaluated by immunohistochemistry. MSI status was assessed using a hexa-plex marker panel by polymerase chain reaction followed by fragment analysis.
RESULTS: Among the 166 cases, MSI analysis was conclusive in 120, being two cases MSI-positive (1.6%). PD-L1 expression was positive in 18.3% of 109 feasible cases. PD-L1 expression was significantly associated with non-visceral metastasis and a dominance of nodal metastasis. The median overall survival (mOS) was 3.7 (95% CI 1.6 – 5.8) months and patients who expressed PD-L1 achieved a better mOS compared to those who did not express PD-L1 (18.7 versus 3.0 months, p-value: <.001). ECOG-PS equal or more than two and PD-L1 expression were independent prognostic factors in multivariate analysis (2.37 and 0.42 respectively).
CONCLUSION: PD-L1 is expressed in a subset (1/5) of patients with CUP and associated with improved overall survival, while MSI is a rare event. There is an urge to explore better the tumor microenvironment as well as the role of immunotherapy to change such a worse clinical outcome.
Widely tunable solid-state source of single-photons matching an atomic transition
Authors: Maruf Rubayet Al , Venuturumilli Sreesh , Bharadwaj Divya , Anderson Paul , Qiu Jiawei , Yuan Yujia , Zeeshan Mohd , Semnani Behrooz , Poole Philip , Dalacu Dan , Resch Kevin , Reimer Michael , Bajcsy Michal 
Published: November 2023

Abstract
Hybrid quantum technologies aim to combine diverse quantum systems, mirroring classical computers' integration of electronic, photonic, magnetic, and mechanical components. Quantum dots in semiconductor nanowires emit high-purity, deterministic single photons with high repetition, while atomic ensembles offer photon storage and strong optical nonlinearities controllable by single photons. To interface quantum dots with atomic ensembles successfully, precise optical frequency matching of these two platforms is crucial. We demonstrate a simple, precise, reversible, broad-range, and local method for controlling the emission frequency of individual quantum dots embedded in tapered semiconductor nanowires. We then interface the quantum dots with an atomic ensemble via single-photons matched to hyperfine transitions and slow-light regions of the cesium D1-line. Our approach allows linking atomic and solid-state quantum systems and can potentially also be applied to other types of nanowire-embedded solid-state emitters, as well as for creating devices based on multiple solid-state emitters tuned to produce indistinguishable photons.
Assessing adverse events associated with chiropractic care in preschool pediatric population: a feasibility study.
Authors: Dolbec Anne , Doucet Chantale , Pohlman Katherine A. , Sobczak Stéphane , Pagé Isabelle 
Published: November 2023

Abstract
Background: Manual therapies are commonly used by healthcare professionals when caring for children. However, few prospective studies have evaluated their adverse events (AEs). This study aims to assess the feasibility of a pragmatic prospective study aiming to report the immediate and delayed (48-hours post-treatment) AEs associated with manual therapies in children aged 5 or younger. Preliminary data on AEs frequency and new/worsening are also reported.
Methods: Chiropractors were recruited through purposive sampling and via a dedicated Facebook group for Quebec chiropractors interested in pediatrics. Legal guardians of patients aged 5 or younger were invited to fill out an online information and consent form. AEs were collected using the SafetyNet reporting system, which had been previously translated by the research team. Immediate AEs were collected through a questionnaire filled out by the legal guardian immediately after the treatment, while delayed AEs were collected through a questionnaire sent by email to the legal guardian 48 hours after the treatment. Feasibility was assessed qualitatively through feedback from chiropractors and quantitatively through recruitment data.
Results: Overall, a total of 28 chiropractors expressed interest following the Facebook publication, and 5 participated. An additional two chiropractors were enrolled through purposive sampling. In total, 80 legal guardians consented to their child's participation, and data from 73 children were included for the analysis of AEs. At least one AE was reported in 30% of children (22/73), and AEs were mainly observed immediately following the treatment (16/22). The most common AEs were irritability/crying (11 children) or fatigue/tiredness (11 children). Feasibility analysis demonstrated that regular communication between the research team and clinicians, as well as targeting clinicians who showed great interest in pediatrics, were key factors for successful research.
Conclusion: Results suggest that it is feasible to conduct a prospective pragmatic study evaluating AEs associated with manual therapies in private practices. Direct communication with the clinicians, a strategic clinicians' recruitment plan, and the resulting administrative burden should be considered in future studies. A larger study is required to confirm the frequency and new/worsening of AEs reported in the current study.
Trial registration: ClinicalTrials.gov., NCT05409859, Registered on June 3 2022. https://clinicaltrials.gov/study/NCT05409859.
The budding yeast heterochromatic protein Sir3 modulates genome-wide gene expression through transient direct contacts with euchromatin
Authors: Radman-Livaja Marta , Bhattacharjee Pritha , Camasses Alain , Galic Hrvoje , Hrgovcic Ana , Demont Lara , Nguyen Linh , Vasseur Pauline 
Published: November 2023

Abstract
The SIR complex (Silent Information Regulator) is the building block of heterochromatic structures that silence underlying genes. The biological function of heterochromatin located in subtelomeric regions is, however still not clear since heterochromatin coverage appears to be limited to a few kbps near chromosome ends and the expression of subtelomeric genes is only marginally affected in the absence of the SIR complex. We use a three-pronged approach to address this question. First, Nanopore-MetID, an in vivo foot printing technique similar to DamID that uses nanopore sequencing technology, identified over a thousand new transient contacts between Sir3 and euchromatic genes that are not detectable by ChIP-seq and revealed a previously undocumented low-density mode of Sir3 binding to subtelomeric regions that extends 15kbps downstream of subtelomeric SIR nucleation sites. Second, our measurements of genome-wide Sir3 exchange rates after exit from starvation show that heterochromatin is a highly dynamic structure in optimal growth conditions. Third, “spike-in” RNA-seq time course experiments in the same conditions reveal that Sir3 modulates global mRNA levels in correlation with fluctuations in nutrient availability. We now propose that subtelomeric regions serve as Sir3 hubs from which Sir3 is brought over to distal sites down the chromosome arm where it transiently contacts euchromatic genes in its path. We hypothesize that contacts between Sir3 and actively transcribed genes facilitate the removal of stalled transcription complexes and allow for optimal genome-wide transcription, which gives wt cells a competitive advantage over sir3Δ cells when nutrients are limited.
IgA Nephropathy and Remitting Seronegative Symmetrical Synovitis with Pitting Edema: a case report
Authors: Damas Juliana , Marouço Catarina , Barata Rui , Pereira Tiago Assis , Fonseca Nuno Moreira , Navarro David , Góis Mário , Viana Helena , Sousa João , Gruner Heidi , Jorge Cristina 
Published: November 2023

Abstract
Introduction: IgA Nephropathy (IgAN) remains the most frequent glomerular disease worldwide, with a broad spectrum of clinical and histological presentations. It has been associated with many secondary causes. The Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) syndrome is an autoimmune disorder characterized by swelling in the extremities and negative autoimmune serological tests. The primary treatment for this condition involves the use of immunosuppressive therapy. Although several triggers have been identified, the exact cause of this condition is still unknown.
Case Presentation: We report a case of a 53-year-old man who presented with severe acute kidney injury, whose etiological study revealed advanced IgAN, associated with pleural and pericardial effusions. Even with volume optimization and dialysis intensification, the pericardial effusion worsened, although the pleural effusion improved. Upper arm arthralgias were developed afterward. An extensive study ruled out other causes and the hypothesis of RS3PE syndrome was considered. Glucocorticoid (GC) therapy was instituted for 6 months with clinical improvement and no recurrence at 2 years follow-up.
Conclusions: The complexity of this case shows the importance of considering a wider diagnosis for the complaints of arthralgias and volume overload in dialysis patients, reinforcing the importance of clinical awareness for other concurrent conditions, whose treatment may be lifesaving.