bluuebunny/crossref_metadata_2025_split huggingface dataset:
Purification, Characterization, and Ferrous Oxidation Kinetics of Iron Oxidase from Acidithiobacillus ferridurans
Authors: Liu Yuandong , He Jiayu , Shangguan Xiangdong , Liu Run , Zeng Xiaofeng , Belqadi Wissal , Wang Kan , Tong Yan , Yu Runlan , Zeng Weimin , Wu Xueling , Shen Li , Qiu Guanzhou 
Published: October 2023

Iron oxidase was proposed to be the initial electron acceptor from the ferrous ion in the iron oxidation of the Acidithiobacillus genus for metal bioextraction; however, its most fundamental property of direct ferrous oxidation kinetics remains undetermined due to the confusion of reaction monitor method. Here, a recombinant iron oxidase from Acidithiobacillus ferridurans Riv11 was constructed, expressed, purified, characterized, and further used to investigate the kinetics and mechanism of ferrous oxidation. This protein is more stable in an acid solution than in a neutral solution. An infrared characteristic peak around 1050 cm−1 of the [Fe4S4] cluster was identified. The [Fe4S4] cluster does not affect the secondary structure of protein, but plays an important role in the stability of protein and strongly absorbs the intrinsic fluorescence of protein, resulting in a great loss of the fluorescence emission. The protein has far more absorbance than those of the iron ions in solution in the visible region; therefore, the maximum difference absorbance around 500 nm between the oxidized and reduced states of protein can be used to monitor the reaction of ferrous oxidation. Accordingly, the kinetic rate constant of the reaction was determined. Bioinformatics analysis and molecular simulation further revealed the underlying molecular mechanism that ferrous ions approach the protein at the edge of a large hydrophobic surface patch nearest to the [Fe4S4] cluster from a direction far from all positively charged residues, which enough enables an efficient electron transfer.
Analysis of wedge-shaped defects’ prevalence and treatment effectiveness
Authors: Basharova O. V. 
Published: October 2023

Relevance. The prevalence of wedge-shaped defects remains high. The increased risk of the fi falling out, the development of a secondary defect around the filling, and the progression of the wedge-shaped defect development are characteristic of the operative treatment of this type of hard dental tissue non-carious lesions. Therefore, the search for new methods of diagnosis, treatment and prevention of wedge-shaped defects remains relevant in modern dentistry. Purpose. The study aimed to evaluate the prevalence of wedge-shaped dental defects and assess the effectiveness of a complex combined effect on dental tissues in non-carious lesions of hard dental tissues.Material and methods. We examined 942 patients aged 35 to 44 years. All underwent a dental examination, according to the WHO recommendations, questionnaire and instrumental diagnosis.Results. The dental examination detected wedge-shaped defects in 324 examined patients (34.4%). Upon presentation, patients with revealed stage I and II wedge-shaped defects complained of aesthetic dissatisfaction (11%), pain when eating (47%), and pain on brushing teeth (54%). According to the examination results before treatment, the volumetric blood flow velocity was 1.9 times lower in the group with a high degree of anxiety than in the group with a low degree of anxiety. The amplitude of the masticatory and temporal muscles at rest was 1.8 times higher in patients with a high anxiety degree than in patients with a low degree of anxiety.Conclusion. After a one-month course of treatment with the combined method proposed by us, the indicators of systolic volumetric blood flow velocity and the average amplitude of the masticatory and temporal muscles at rest in patients with high anxiety became comparable to those of the control group.
Increasing functional enamel resistance in children and adolescents during orthodontic treatment with removable appliances
Authors: Fedorova A. V. , Soldatov V. S. , Soldatova L. N. , Iordanishvili A. K. 
Published: October 2023

Relevance. The average time of orthodontic treatment in children is often several years. However, the final mineralization of erupted permanent teeth occurs during this period. The skills developed at this age rarely guarantee a high level of individual oral hygiene. Thus, modern removable appliances (aligners) in children with mixed dentition have several advantages. Remineralization therapy performed simultaneously with orthodontic treatment is one of the essential advantages of using aligners.Purpose. The study aimed to conduct a comparative clinical assessment of changes in the enamel acid resistance and remineralization effectiveness in patients undergoing orthodontic treatment with removable appliances (aligners). Material and methods. Orthodontic follow-up observation involved 59 patients aged 8 to 14 years for six months. They made up three observation groups. The first (control) group included 17 people who visited the orthodontist for a check-up. The second (21 people) and third (21 people) groups comprised patients undergoing orthodontic treatment with aligners. Patients of the second group added ASEPTA TEENS paste to their daily oral care complex. Patients of the third group used ASEPTA remineralizing gel for children besides ASEPTA TEENS paste. The TER test assessed enamel acid resistance, and remineralization effectiveness was determined throughout the study.Results. The comparative analysis revealed that the enamel acid resistance increased in patients of the third group who had followed our recommended scheme of oral care product use with a complex of ASEPTA TEENS paste and ASEPTA remineralizing gel for children. The group showed a remineralization effectiveness of 39.5% after six months. Patients of the second group who used ASEPTA TEENS paste without gel applications for six months also showed an increase in remineralization effectiveness of 19.5% compared to the baseline.Conclusion. The results obtained during the study allow us to recommend ASEPTA remineralizing gel for children for oral care during orthodontic treatment with removable appliances (aligners) in patients with mixed dentition. Removable aligners allow you to combine orthodontic treatment and the preventive use of mineralizing agents for forming strong enamel and protecting it from demineralization.
HUBUNGAN MOTIVASI BELAJAR DENGAN INDEKS PRESTASI KOMULATIF (IPK) MAHASISWA S1 KEPERAWATAN UNIVERSITAS ISLAM AS-SYAFI’IYAH JAKARTA
Authors: Partinah Tien , Harahap Syawal Basri 
Published: October 2023

ABSTRAK
Pendahuluan Mahasiswa adalah harapan bangsa, majunya bangsa ditentukan oleh generasi muda, oleh karena itu perlunya lulusan S1 keperawatan yang profesional. Perubahan ilmu pengetahuan dalam era globalisasi berdanpak langsung terhadap pelayan kesehatan, mutu pendidikan tidak akan lepas dari kegiatan belajar. Hasil kegiatan belajar adalah prestasi akademik. Tujuan penelitian untuk mengetahui hubungan motivasi belajar dengan indeks prestasi komulatif (IPK) mahasiswa S1 keperawatan Universitas Islam As-Syafi’iyah Jakarta. Metode penelitian ini adalah metode deskriptif korelatif dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan Stratified Random Sampling dengan jumlah populasi 96 mahasiswa, didapat jumlah sampel 80 mahasiswa. Instrumen penelitian menggunakan kuesioner dan dokumentasi. Analisa data memakai univariat dengan menggunakan µ dan %, bivariat menggunakan product moment dengan α 5%. Hasil Penelitian menunjukkan 55% motivasi belajar mahasiswa dalam kategori baik dan 83,8% prestasi akademik mahasiswa kategori baik. Uji korelasi product moment diperoleh nilai pearson correlation = 0,292 nilai ini lebih besar dari nilai r tabel (yaitu α = 5% atau r tabel = 0,220), maka hipotesis nol ditolak, terdapat hubungan yang sedang antara motivasi belajar dengan prestasi akademik (IPK). Kesimpulan terdapat hubungan yang signifikan antara motivasi instrinsik dengan (IPK) dengan kategori cukup erat dan motivasi belajar dengan (IPK) dengan kategori sedang pada Mahasiswa S1 Keperawatan Universitas Islam As-Syafi’iyah Jakarta. Saran agar mahasiswa lebih meningkatkan semangat belajar dan berdoa sebelum perkuliahan dimulai.
PENINGKATAN PELAKSANAAN KESELAMATAN PASIEN PERIOPERATIF PERAWAT PELAKSANA MELALUI PENGENDALIAN KEPALA RUANGAN DI RS X
Authors: Sumadi Aam , Handiyani Hanny , Nuraini Tuti 
Published: October 2023

Introduction the risk of errors in the perioperative period is very large so that patient safety should be supported and the team is obligated to cooperate in raising awareness toward the occurrence of the incident or event that is not expected. Head nurse control function ensure appropriate planning objectives accomplished. The purpose aims to know the effectiveness of the control function of the head nurse toward the implementation of perioperative patient safety. This research method research design using preexperiment with pretest-posttest design without control. The sample size of 75 nurses that involved in perioperative nursing service. The results data analysis using paired t test represent the effectiveness of the control function of the head nurse with p value = 0.0001 (CI = 120.79 – 127.01) and the improve of implementation of perioperative patient safety by nurses. The conclusion post intervention that indicates positive correlation with p value = 0.0001 (CI = 141.59 – 147.15). Suggestions this research recommends there should be monitoring and evaluation of implementation of the control head room and a development model that is more complete control
PENGARUH TERAPI RENDAM AIR HANGAT PADA KAKI TERHADAP KUALITAS TIDUR LANSIA DI POSBINDU WIJAYA KUSUMA JATIBENING BARU TAHUN 2019
Authors: Noviyanti Noviyanti , Istiqomah Istiqomah 
Published: October 2023

Tidur adalah status perubahan kesadaran ketika persepsi dan reaksi individu terhadap lingkungan menurun. Gangguan tidur sering terjadi pada lansia yang berdampak pada menurunnya kualitas tidur. Terapi merendam kaki dengan air hangat dapat menyebabkan pembuluh darah dimana hangatnya air membuat sirkulasi darah menjadi lancer dan menimbulkan perasaan rileks sehingga meningkatkan kualitas tidur. Tujuan penelitian untuk mengidentifikasi pengaruh terapi rendam air hangat pada kaki terhadap kualitas tidur lansia di Posbindu Wijaya Kusuma Jatibening Baru. Metode penelitian menggunakan metode eksperimen melalui one group pre test and post test design. Ukuran populasi sebanyak 57 orang lansia. Ukuran sampel sebanyak 36 responden yang diambil dengan teknik simple random sampling. Pengukuran skor kualitas tidur menggunakan instrument The Pittsburgh Sleep Quality Index. Analisis data menggunakan analisis univariat dan bivariat melalui statistk uji Wilcoxon dengan α= 5%. Hasil penelitian menunjukkan adanya pengaruh terapi rendam kaki dengan air hangat terhadap kualitas tidur lansia dengan nilai p = 0,000. Simpulan terjadi peningkatan kualitas tidur lansia setelah diberi perlakuan terapi rendam kaki dengan air hangat. Saran diharapkan dapat menjadi pilihan alternative bagi perawat untuk mengaplikasikan terapi rendam kaki dengan air hangat untuk meningkatkan kualitas tidur lansia.

Sleep is a status change of consciousness when an individual's perception and reaction to the environment decreases. Sleep disturbance often occurs in the elderly which results in decreased sleep quality. Therapy to soak the feet with warm water can cause blood vessels where warm water makes the blood circulation smooth and cause a feeling of relaxation thereby improving sleep quality. The purpose of this study was to identify the effect of warm water soak therapy on the feet to the sleep quality of the elderly in Posbindu Wijaya Kusuma Jatibening Baru. The research method uses experimental methods through one group pre-test and post-test design. The population size is 57 elderly people. The sample size was 36 respondents taken by simple random sampling technique. Measurement of sleep quality scores using the Pittsburgh Sleep Quality Index instrument. Data analysis used univariate and bivariate analysis through Wilcoxon test statistics with α = 5%. The results showed the influence the effect of warm water soak therapy on feet to the sleep quality of elderly with a p-value = 0,000. Conclusions increased the sleep quality of elderly after being treated with warm watersoak therapy on feet. Suggestions are expected to be an alternative choice for nurses to apply warm water soak therapy to improve the quality of sleep in the elderly.
Persepsi Masyarakat Lokal Mengenai Dampak Lingkungan dari Festival Jazz Gunung Bromo
Authors: Sibarani Jessica Anzamar 
Published: October 2023

Persepsi Masyarakat Lokal terhadap Dampak Lingkungan dari Festival Jazz Gunung Bromo adalah sebuah studi yang mengeksplorasi persepsi penduduk Wonotoro mengenai dampak lingkungan dari festival tersebut. Festival ini diadakan di amfiteater terbuka di Jiwa Jawa Resort Bromo di Wonotoro, yang terletak di dalam kawasan Taman Nasional Bromo Tengger Semeru, yang merupakan rumah bagi banyak flora dan fauna langka yang dilindungi. Penelitian ini bertujuan untuk mengkaji dampak positif dan negatif terhadap lingkungan dari penyelenggaraan festival musik di taman nasional.

Metode kuantitatif digunakan, dan kuesioner didistribusikan kepada 96 penduduk desa Wonotoro. Hasil penelitian menunjukkan bahwa pendidikan dan pendapatan per bulan menentukan persepsi positif penduduk tentang lingkungan yang ditimbulkan dengan adanya festival, sementara status perkawinan, tingkat pendidikan, dan pendapatan per bulan menentukan persepsi negatif. Hasil penelitian juga menunjukkan bahwa penduduk yang berpendidikan lebih tinggi lebih sadar akan lingkungan, sementara penduduk yang berpendidikan lebih rendah merasakan dampak negatif.

Penelitian ini juga mengidentifikasi dua faktor baru yang berkaitan dengan perubahan perilaku masyarakat dan dampak buruk terhadap lingkungan akibat adanya event internasional berskala besar. Faktor pertama meliputi kesadaran masyarakat dan keindahan lingkungan, sedangkan faktor kedua meliputi kemacetan jalan, polusi suara, penurunan kualitas udara, sampah, dan keramaian yang tidak menyenangkan.

Kata kunci: Dampak Festival, Dampak Lingkungan Event/Festival, Masyarakat Lokal, Persepsi
Un manoscritto «ritrovato»: il Codex Admontensis 517
Authors: Magoga Alessio 
Published: October 2023

Within the framework of research on the Anulus seu dialogus inter Christianum et Iudaeum, written by the monk Rupert of Liège or of Deutz (about 1075-1129), a manuscript which was given up for lost by some scholars (R. Haacke e M. Neusner) has been identified. It is the Cod. 517, housed in the Benedictine abbey of Admont in Styria (Austria). This article briefly explains the significance of Rupert’s work, transmitted in this manuscript, and notes the strange oblivion in to which the manuscript had fallen in recent decades. The article offers the first complete description of the manuscript, and points out the main distinguish elements of its external aspect and contents. Of particular interest -and suggestion of future research -are the partial erasure of the name of the owner and the presence of two abruptly texts : the canon of a local synod (Auxerre ?) and the first part of the De sacramentis excommunicatorum
of Bernaldo of Constance (XI century).
Certainty Factor Method for an Expert System for Orthopedic Disease Diagnosis
Authors: Savilla Intan , Rianti Eva , Yenila Firna 
Published: October 2023

Health is an important thing in human survival, including bone disease. Some people think that bones are passive, dead tissue, but they are not. Bones and skeleton are a very important part of orthopedics. Bones are not only a framework that strengthens the body but are also part of the structure of joints, as protection for the body, where the ends of muscles are attached. One of the diseases that is widely felt in society is bone disease. Bone disease is a condition that damages the skeleton and makes bones weak and susceptible to fractures. The high rate of diseases that attack the bones is caused by the conditions and behavior of society, such as stress, lack of exercise, wrong diet. Another cause is also ignorance and lack of knowledge about bone disease itself. By using an expert system, patients can save time going to the hospital, because the system replaces experts in their field, especially chiropractors. The method that will be used in this research is the Certainty Factor Method. The results obtained later are diagnostic results based on the symptoms entered and issued in the form of decisions and percentages. The diagnosis results identified Cervical Spondylosis (Nerve Pain) with a confidence level of 89.60%. It is hoped that this expert system will make it easier for patients to diagnose bone disease and carry out initial treatment in treating the disease.
Peran Neonatal Comfort Care di Neonatal Intensive Care Unit
Authors: Wicaksana Andhika , Wilar Rocky , Rompis Johnny L. 
Published: October 2023

Abstract: Comfort is an important component of the treatment of neonates in the National Intensive Care Unit (NICU). Due to the efforts given in the NICU, neonates tend to be exposed with various surroundings which made them receive excessive stimuli. These can lead to increased level of stress and pain, and have an impact on the health and growth of the neonates in the NICU. Therefore, it is necessary to carry out procedures to keep the baby comfortable by maintaining the stress level through neonatal comfort care. This study aimed to determine the role of neonatal comfort care during the care of neonates in the NICU. This was a literature review study. Literatures were searched in PubMed, Google Scholar, and Clinical Key databases. The results obtained 10 literatures to be reviewed. The statistical results showed that through the implementation of pharmacological and non-pharmacological procedures, neonatal comfort care had a good impact on physiological distress and neonates’ comfort based on the comfort rating scale for neonates in the NICU. In conclusion, neonates’ comfort in the NICU increases significantly after being given neonatal comfort care.
Keywords: Neonatal Comfort Care; Neonatal Intensive Care Unit; neonates in care

Abstrak: Menjaga kenyamanan neonatus merupakan komponen penting dalam perawatan di lingkungan Neonatal Intensive Care Unit (NICU). Dalam upaya pengobatan yang dilaksanakan di NICU, neonatus akan terpapar lingkungan yang bervariasi hingga menerima stimuli berlebihan yang dapat menyebabkan peningkatan stres maupun rasa nyeri akibat perawatan invasif yang dilaksanakan. Oleh karena itu diperlukan prosedur pelaksanaan dalam memelihara kenyamanan neonatus untuk menjaga tingkat stres melalui neonatal comfort care. Penelitian ini bertujuan untuk mengetahui peran neonatal comfort care pada perawatan neonatus di NICU melalui suatu literature review. Pencarian literatur dilakukan di database PubMed, Google Scholar, dan Clinical Key. Hasil penelitian mendapatkan 10 literatur untuk diulas. Hasil statistik dari artikel yang diulas menunjukkan bahwa neonatal comfort care melalui pelaksanaan prosedur farmakologi dan non-farmakologi memiliki berdampak baik terhadap distres fisiologis dan kenyamanan neonatus berdasarkan skala penilaian kenyamanan terhadap neonatus yang berada di lingkungan NICU. Simpulan penelitian ini ialah kenyamanan neonatus yang berada di lingkungan NICU meningkat bermakna secara statistik setelah pemberian neonatal comfort care.
Kata kunci: Neonatal Comfort Care; Neonatal Intensive Care Unit; bayi dalam perawatan
Perubahan Ilmu Pendidikan Dalam Prespektif Paradikma Revolusi Thomas S Kuhn
Authors: B. Mutmainna , Yuanita Yuanita , Arifi Ahmad 
Published: October 2023

<p>Perkembangan ilmu pengetahuan terjadi diakibatkan oleh adanya proses pembaharuan terhadap teori-teori yang sudah ada, yang dibentuk berdasarkan dari hasil penemuan ilmiah. Hasil dari ilmu pengetahuan hendaknya memberi dampak positif bagi manusia, namun di sisi lain juga memberikan dampak negatif. Penulisan ini merupakan penelitian studi pustaka yang bertujuan untuk mendapatkan data dan informasi terkait yang berkaitan dengan pemikiran Thomas S Kuhn mengenai paradigma dan revolisi ilmiah terhadap ilmu pendidikan. Pengumpulan data dilakukan dengan cara dokumentasi dan mengumpulkan informasi serta data-data dari jurnal artikel yang berkaitan dengan pembahasan. Data-data yang telah di dapatkan kemudian dilanjutkan dengan cara di analisis melalui reduksi data dan display data Paradikma merupakan suatu model atau pola yang digunakan untuk membandingkan teori ilmu lama dengan teori ilmu pengetahuan dan kerangka fikir Dalam dunia penelitian, paradikma di bagi atas dua ciri yang menjadi identitasnya. Diantaranya: satu terdapat unsur baru yang dapat menarik ilmuan lain untuk keluar dari persaingan kerja dalam kegiatan ilmiah sebelumnya. Dua, menawarkan pula persoalan-persoalan baru yang masih terbuka dan belum terselesaikan. Revolusi ilmu meerupakan suatu kejadian yang membahas tentang perubahan pola berfikir serta pendapat manusia dalam upaya memperoleh ilmu pengetahuan. Dimana perubahan-perubahan tersebut meliputi cara berfikir konkrit ke cara berfikir realitas. Rangkaian siklus revolusi llmiah dibedakan menjadi empat tahap diantaranya:tahap persiapan, tahap normal, tahap kritis, dan tahap revolusi ilmiah</p>
Central Nervous System-related Conditions and Associated Healthcare Resource Use Among Japanese nmCRPC Patients Based on Retrospective Claims Data
Authors: Ledesma Dianne A. , Chua Jonathan L. , Tang Susan S.H. , Lim Xiu W. 
Published: October 2023

Background: Japanese patients with prostate cancer are typically treated with primary androgen deprivation therapy (ADT), most commonly administered as a combination of a luteinizing hormone-releasing hormone (LHRH) agonist and an antiandrogen (AA). Since LHRH agonists and AA therapy can be maintained for several years, the long-term effects of these treatments on patients must be carefully considered, including the risk of concomitant central nervous system (CNS) conditions which could affect treatment choices. Objective: To describe CNS-related concomitant conditions during ADT and/or AA treatment and the subsequent healthcare resource utilization in Japanese nonmetastatic castration-resistant prostate cancer (nmCRPC) patients. Methods: Patients diagnosed with nmCRPC and CNS-related conditions while on ADT and/or AA therapy between April 2009 and August 2017 were retrospectively followed up for a maximum of 2 years using a claims database. Results: A total of 455 patients (average age, 78.5 years), were included. The 3 most common concomitant CNS-related conditions were pain (~60% of events), insomnia (~30%), and headache (2%-3%). The frequency of CNS-related conditions in these patients increased approximately threefold after starting AA therapy (before, 969 events; after, 2802). On average, a patient had 10 episodes of concomitant CNS-related conditions in a year. Medical costs did not significantly increase due to CNS-related conditions. Discussion: The most frequently reported CNS-related conditions were pain, insomnia, and headaches. Furthermore, more concomitant CNS-related conditions 1 year after CRPC diagnosis and 1 year after starting AA treatment were recorded. Conclusion: Patients with nmCRPC experience an increase in the frequency of concomitant CNS-related conditions, including pain, insomnia, and headaches, after CRPC diagnosis or starting AA treatment. Future research should explore the causes of this increased frequency.