bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrum of intestinal lesion: A clinicopathological study in a tertiary care centre
Authors: Usman Syeda Iqra , Khan Zoha , Khan Roobina , Afroz Nishat , Harris Syed Hasan 
Published: January 2024

Intestine has wide spectrum of diseases comprising neoplastic and non-neoplastic lesions. Inflammatory bowel diseases are showing increasing trend and intestinal neoplasms are the most frequently observed and leading cause of death in India. This study aims to find the occurrence of various intestinal lesions, classify them as neoplastic and non-neoplastic and to correlate the histopathological findings with clinical profile of patient in tertiary care hospital of north India. 1129 biopsies and resection specimens of intestinal lesions were examined over a period of two years. Sections were fixed, paraffin embedded and stained by H&E. Immunohistochemistry was applied wherever required. Nearly two third patients were males in their second decade who presented with abdominal pain as the most common complaint and majority were diagnosed with non-neoplastic diseases. Among non-neoplastic lesions non-specific inflammation was predominant in small intestine (47.04% cases) and appendicitis (55.0%) in large intestine. Adenocarcinoma was predominant in both small and large intestine with 80.77% and79.45% of neoplastic cases respectively. This work gives a panoramic view of different intestinal pathologies and emphasises on the need of planning accurate diagnostic and screening strategies along with effective treatment plans both for neoplastic as well as non-neoplastic diseases.
Invasive solid papillary breast carcinoma without neuroendocrine differentiation
Authors: Jayakumar Priya , Chauhan Devender Singh 
Published: January 2024

Solid papillary carcinoma (SPC) is considered a rare malignant breast tumor. This tumour can be either in situ or invasive .Both usually show excellent prognosis. Solid papillary carcinoma often shows neuroendocrine differentiation. 74-year-old lady an ulcerative retroareolar mass in the right breast. CECT Thorax revealed a large lobulated fungating ulceroproliferative mass lesion in the right breast with pectoral muscle involvement.without neuroendocrine differentiation. SPC with invasion is an uncommon variant of papillary carcinoma with frequent mucinous differentiation. Neuroendocrine differentiation although supports the diagnosis of solid papillary carcinoma may or may not be present.
Assessment of critical impact of superbugs in human health: A known beyond
Authors: Karwa Pawan Nandkishor , Bhole Ritesh P , Gawade Mahesh 
Published: January 2024

A superbug is described as a bacterium that has seen to develop resistance to traditional treatment of antibiotics. The World health organization has produced the first-ever fulfilled report on the AMR danger, which consists the information from 114 nations and ranks it amongst the one of the severe global health hazards of the 21 century. Every year, about 1 million people die due to the non-treatable drug-resistant diseases caused by these superbugs. Bacterial resistance is on the rise, putting many of our current antibacterial treatments in danger. Discovery of brand-new antibiotics has lagged behind the growth of germs resistant to them. Numerous novel approaches to target different substances in bacterial cells have been developed and are being researched. The present review emphasizes on the various types of superbugs with its possible solution. Also, it illustrates that, we should not be startled by the fast emergence of resistant pathogens dubbed "superbugs" by the media but what has been astonishing is the rapidity with which these superbugs have evolved and spread resistance, frequently at little or no cost to their health. The article provides an overview of the most prevalent forms of superbugs and potential novel medicines that might be utilized in a clinical setting shortly to fight these superbugs.
A study on clinico- epidemiological profile & histopathological profile of cutaneous vasculitis
Authors: Yadav Ram Gyan , Rijal Arpana , Khadaka Dhan Keshar , Upadhayaya Paricha 
Published: January 2024

: The study aimed to analyse the potential etiological factors, clinical presentation, past medical history & laboratory findings in patients with biopsy-proven cutaneous vasculitis to better understand the disease and identify the disease classifications. The objective of this study was to establish a database of the clinic-epidemiological profile and histopathological features of cutaneous vasculitis in a tertiary hospital in Eastern Nepal.: A Descriptive cross-sectional study was planned to analyse and study the clinic-epidemiological profile and histopathological features of cutaneous vasculitis in Nepal. This study has reviewed the facts which were published earlier to determine the current scenario by vast study of statistics and derivation of facts. Proper examination of data was made to evaluate with final conclusion. The study included sample size of 30 consecutive patients with biopsy-proven cutaneous vasculitis attending the Dermatology outpatient department and admitted to the dermatology ward at B.P. Koirala Institute of Health Science, Dharan. : The study population of 30 patients with biopsy-proven cutaneous vasculitis, with an average age of 32.96 years, and a female-to-male ratio of 1.3:1. The majority of patients (66.67%) had lesions lasting less than 6 weeks, and acute disease was observed in 86.66% of the cases. The most common symptoms were itching (73.66%) and arthralgia (66.67%). Palpable purpura was the predominant cutaneous manifestation (70%), mainly distributed on the legs and ankles (93.33%). Elevated ESR was the most common laboratory abnormality (73.33%). Histopathological examination revealed leukocytoclastic vasculitis in 97% of cases, with predominantly neutrophilic infiltrates. Henoch-Schoenlein purpura (HSP) was the most common classification (43.33%), followed by urticarial vasculitis (26.67%).: This study provides valuable insights into the clinic-epidemiological profile and histopathological features of cutaneous vasculitis in the Nepalese population. It highlights the diverse clinical presentation and laboratory abnormalities associated with the condition, as well as potential etiological factors and disease classifications. The findings contribute to improved understanding, diagnosis, and management of cutaneous vasculitis. Further studies with larger cohorts are needed to validate and expand upon these findings.
Methotrexate toxicity encountered in dermatology department: A retrospective study at tertiary care center in western India
Authors: Modha Jay Dhirajlal , Bhabhor Bhavana Bharatbhai , Patel Bharati Kamlesh , Bhuptani Neela Vishanjibhai 
Published: January 2024

Methotrexate (MTX) is considered a relatively safe drug when prescribed at dose ranging from 7.5mg-30mg per week. Severe acute toxicity is rare and present with mucositis, cutaneous ulceration and pancytopenia. Most cases occur as the result of inadvertent overdosing due to erroneously taking the drug daily. A retrospective study of 10 cases of acute methotrexate toxicity in patients attending the dermatology OPD at P. D. U govt. medical College and hospital, Rajkot during a period of 1 year was done. Out10 patients, 7 had both oral and cutaneous involvement, 4 had genital mucosal involvement while 2 cases had only oral ulcerations. Organ -specific toxicities includes pancytopenia in all cases, as well as hepatoxicity, renal toxicity, and GI toxicity in 3 patients. Additionally, cutaneous toxicity was observed in 6 cases. “Of the 10 patients, 2 recovered after stopping methotrexate with supportive care. The remaining 8 received injectable folinic acid, resulting in recovery for 6 patients, but 2 patients unfortunately died during treatment. Although MTX appears to be a safe and effective medication when used at low-dose, acute MTX toxicity can be a life threating emergency when comorbidities are not addressed. Sensitization amongst doctors, general practitioners and resident doctors is of paramount importance to identify possible MTX toxicity in earlies phases and in a way ensure earliest management.
Acute generalized exanthematous pustulosis secondary to spider bites: Clinico-dermoscopic findings and review of literature
Authors: Rather Shagufta , Nazim Malik , Aslam Aqib 
Published: January 2024

Acute generalized exanthematous pustulosis (AGEP) or toxic pustuloderma is a febrile adverse cutaneous reaction, characterized by small non-follicular sterile pustules. AGEP can occur in any age group and is found to be more common in women. A large proportion (&#62;90%) of cases are triggered by medications, particularly macrolides and aminopenicillins. The occurrence of AGEP following spider bite has been rarely documented in the literature.We report two cases who presented to us with AGEP following spider bite along with dermoscopic findings and also present a brief review of literature on the same.
Oral tofacitinib in refractory chronic spontaneous urticaria
Authors: Godse Kiran , Shibu Elen Elu , Singh Gauri , Gautam Manjyot , Patil Sharmila 
Published: January 2024

Chronic spontaneous urticaria (CSU) is a skin condition marked by the emergence of wheals on their own that persist for six weeks or more. CSU is quite common, affecting up to 1% of the population, and has a serious detrimental effect on a patient's health and quality of life. Antihistamines (AH) are currently the backbone of treatment for chronic urticaria (CU), however up to 40% of patients do not respond to even large (four-fold) daily dosages of AH. Tofacitinib is a small-molecule that inhibits intracellular signalling of several important cytokines involved in the inflammatory cascade and blocks JAK1/3. While there are reports of tofacitinib's positive effects in patients with mast cell activation disorder, there are none in those with urticaria. The aim of our study is to assess the efficacy of oral tofacitinib in refractory chronic spontaneous urticaria. 5 cases of refractory CSU between the age group of 20 to 40 years were included in our study and they were followed up for 6 months. The patients were started on oral tofacitinib 5mg twice a day. On every weekly follow-up, we used clinical assessment, urticaria activity score and urticaria control test to evaluate the treatment response The usage of oral tofacitinib significantly improves the clinical picture in refractory CSU. Although more research is required to determine Tofacitinib's effectiveness in CSU, our study raises the possibility that it could represent a novel therapeutic option for individuals with refractory CSU.
Role of cetrorelix in the prevention and treatment of ovarian hyperstimulation syndrome: A prospective case control study
Authors: Inani Anita 
Published: January 2024

Because of its terrible effects, ovarian hyperstimulation syndrome (OHSS) has long piqued the interest of medical professionals. Since the syndrome is an iatrogenic condition brought on by elective ovarian stimulation in the pursuit of pregnancy, its complete prevention is imperative. The gonadotropin releasing hormone (GnRH) antagonist Cetrorelix has been shown in some studies to be beneficial in the prevention of OHSS as well as an effective treatment for the condition. Therefore, we created a study at a hospital to find out how Cetrorelix works to prevent and treat OHSS in patients undergoing long and short protocols for those undergoing embryo transfer and in-vitro fertilization (IVF–ET) who are susceptible to the illness.The study includes 102 patients undergoing COS for IVF in total. To stimulate each case, a long and a short protocol were employed. Depending on whether a GnRH antagonist was administered following ovum pick-up (OPU), the patients were split into two groups: the control group (n = 51) and the Cetrorelix (antagonist) group (n = 51). Beginning on the day of ovum pickup, the study group received five days' worth of Cetrorelix 0.25 mg.: While the antagonist group had a significantly higher moderate OHSS incidence (p=0.01), the incidence between mild and severe OHSS was considerably reduced(p&#60;0.05). Not a single patient experienced critical OHSS. OHSS can be prevented and treated effectively by administering the GnRH antagonist Cetrorelix to patients undergoing either a long- or short-term protocol during the early luteal phase.
HIGIENE PENJAMAH MAKANAN DAN SANITASI KANTIN SEKOLAH DASAR NEGERI DI KECAMATAN MULYOREJO, SURABAYA
Authors: Syaﬁrah Sarah , Andrias Dini Ririn 
Published: January 2024

Food poisoning is one of health problems which caused by consumption of contaminated food. Application of hygiene and sanitation in the school canteen is a form of food contamination prevention. This study was aimed to describe hygiene of food handlers and sanitation of elementary school canteens in Mulyorejo subdistrict. This was a quantitative descriptive research. Population in this research was 13 elementary school canteens in Mulyorejo subdistrict. Purposive sampling was used in this study based on the food sold which were not packaged food as much as 9 canteens. The study showed that six food handlers (66,67%) had at least one infectious disease in the last three months. The majority of food handlers had good handwashing habit before touching foods (66,67%) and after contact with other substance (55,56%). The majority of food handlers (77,78%) had short and clean nail, also 88,89% wore clean and tidy cloths. The sanitation facilities that did not meet requirements of KEPMENKES No. 1098/MENKES/SK/VII/2003 were the availability of bins (88.89%) and handwashing place (100%). The Sanitary of food serving such as table serving (55.56%) and maximum limit of washed equipment (55.56%) are not eligible. The conclusion from this study is the hygiene of food handlers in the school canteens are generally good, while the overall condition of school canteens sanitation is less appropriate compare to the standards. This study recommends the urgency of sanitation facilities improvement in school canteens by school authorities of Mulyorejo subdistrict.Keywords: hygiene, canteen, food handlers, sanitation
DAYA TERIMA DAN TOTAL COST KOMBINASI SARI KULIT BUAH NAGA MERAH DAN SARI BUAH JAMBU BIJI MERAH
Authors: Sari Syafrina Mareta , Adi Annis Catur , Andrias Dini Andrias 
Published: January 2024

Antioxidant plays a role as the free radical savaging. The red guava and the red dragon fruit peel contain high antioxidants so it is potentially to be a functional product. The aim of this study was to analyze the effect of red guava juice and red dragon fruit peel essence addition on yoghurt acceptability and total cost. The research used a factorial design of 5 repetitions on 5 formulas. There are 1 control formula (F0) and 4 modiﬁ cation formulas (F1, F2, F4, F5) with the addition of red guava juice and red dragon fruit peel. The panelist on this research consist of 30 untrainedpanelists. Descriptive analysis and inferential statistic using Friedman and Wilcoxon Sign Rank Test with α = 0,05 were used to analyze the difference of acceptability between the formulas. Panelists showed that the best treatment was F4 yoghurt formula (44% addition of fruit juice with the ratio of guava juice and red dragon fruit peel 50:50) and it has the most preferred acceptability (color, aroma, texture, and taste) with the average value was 2.91 and food cost per serving (100 ml) was Rp 2.900,00. Formula F4 has a good acceptability and lower total cost than commercialyoghurt. This formula has a potential to be an alternative functional drink. The aroma of yoghurt can be increased by eliminate cooking process on the red dragon fruit peel juice.Keywords: acceptability, red guava, red dragon fruit peel, total cost, yoghurt
On Standardization and Evaluation of Continuous Glucose Monitoring Systems
Authors: Momynaliev K. T. , Prokopyev M. V. , Ivanov I. V. 
Published: January 2024

Continuous glucose monitoring (CGM) systems are often used to monitor blood glucose levels. Most commercially available CGM systems continuously measure glucose concentrations in the interstitial fluid of subcutaneous adipose tissue. However, there is currently no internationally accepted reference method for measuring interstitial fluid glucose, which is a prerequisite for metrological traceability of glucose measurements obtained using CGM. Since manufacturers do not provide information about the traceability chain and measurement uncertainty of their systems, CGM-derived glucose values cannot currently be adequately traced to standards or higher order reference measurement procedures. Additionally, the «mean absolute relative difference» (MARD) often used to describe the analytical performance of CGM systems is dependent on many factors. For example, the MARD can be significantly affected by the «lag time» between the change in blood glucose and interstitial glucose, especially at high rates of change in glucose. Finally, modern automated insulin delivery (ADI) systems with integrated CGM can automatically suspend or increase insulin infusion in response to current and/or predicted hypoglycemic and hyperglycemic phenomenon in children and adults with type 1 diabetes mellitus (T1DM). The purpose of the review is justification of the necessity to establish metrological traceability of glucose measurements with CGM systems, as well as a discussion of the analytical and clinical characteristics of CGM systems proposed by various professional communities. Based on the results of the review, it was concluded that it is necessary to 1) develop metrological support for glucose measurements performed using CGM systems, 2) solve the problems of ensuring the accessibility and usability of CGM systems by patients in real conditions.
Certified Reference Material for the Composition of Phthalates in a Polymer Matrix Based on Polyvinyl Chloride
Authors: Budko A. G. 
Published: January 2024

The purpose of the study was to develop a new CRM for the composition of the mass fraction of phthalates in a polymer matrix based on polyvinyl chloride for validation and/or verification of measurement methods such as GOST R ISO 8124-6-2021, GOST R ISO 14389–2016, GOST R ISO 16181–2015 etc. In the study, a method for preparing the starting material of the CRM was tested and successfully implemented, and a critical analysis of methods for measuring the content of di(n-butyl)phthalate and di(2-ethylhexyl)phthalate was carried out. The gas chromatography/isotope dilution mass spectrometry method was chosen as the main method for a quantitative determination of the certified value of the measured value of the mass fraction of di(n-butyl)phthalate and di(2-ethylhexyl) phthalate. In accordance with RMG 93–2015, GOST 8.315-2019, and GOST ISO Guide 35–2015, the standard uncertainty of the certified CRM value from the characterization method, from heterogeneity and instability of the material was assessed. The expanded uncertainty of the certified value was calculated. As a result of the work, a new CRM for the composition of the mass fraction of phthalates in a polymer matrix based on polyvinyl chloride was approved. Certified CRM values are metrologically traceable to GET 208 in accordance with metrological hierarchy according to the verification schedule through GSO 11366–2019. A CRM composition for the mass fraction of phthalates in polyvinyl chloride has the following standardized metrological characteristics: mass fraction of di(n-butyl)phthalate – 0.046 mg/g and di(2-ethylhexyl)phthalate – 45.8 mg/g; the relative expanded uncertainty at k = 2, P = 0.95 is 10 %. The CRM is stored in sealed bottles in a dry place, protected from light, at a temperature from 2 °C to 8 °C. The shelf life of the CRM is 3 years. The developed CRM can be used in solving any measurement problems and performing various types of metrological work, including metrological purposes in the field of polymer and rubber industries, food industry, environmental protection, and scientific research.
The Effect of Students' Attitudes Towards Exercise, Diet and Body Composition on Students' Physical Fitness Post-Covid-19
Authors: Rhama Mashuri  , Kurnia Tahki  , Yasep Setiakarnawijaya  
Published: January 2024

The purposeof this study is to find out the direct influence of Exercise Attitude, Diet, and Body Composition on the Physical Fitness of students of Al- Azhar Islamic High School in Bekasi City as many as 62 samples using the Purposive Sampling withdrawal technique. data collection techniques in the form of numbers, written statements, as well as oral information and various facts based on the focus on the research being studied. By giving questionnaires / questionnaires with a likert scale. and Observation. The analysis technique uses a path analysis approach (path analysiss). The results of the analysis were obtained, as follows: 1). There is a significant influence of Exercise Attitudes on Physical Fitness. 2). There is a significant influence between Diet and Physical Fitness. 3) There is a significant influence between Body Composition on the Physical Fitness of Students of Al-Azhar Islamic Senior High School, Bekasi City in the Post-Covid-19 Period.
Bautismo y confirmación de la Generación Reset (1989-1999). Un análisis tematológico de la reciente poesía española
Authors: Plaza González Pedro J. 
Published: January 2024

El presente estudio parte de la definición de generación aportada por José Ortega y Gasset y de su desarrollo crítico para acotar un tiempo histórico —nacimiento, acontecimientos, sensibilidades, formación, aficiones— y un espacio literario —contactos generacionales, magisterios, publicaciones, lenguaje— en los que poder englobar a una parte relevante y valiosa de la poesía española reciente, a la cual se ha denominado Generación Reset. Así, se ofrece un análisis tematológico detallado de su producción lírica que se estructura en un total de cinco bloques de contenido: 1) la cotidianeidad, la ciudad y los males de comienzo de siglo, donde se examinan elementos tales como la música, las nuevas tecnologías, las redes sociales, la ciudad y sus espacios, la publicidad, la cultura pop, el futuro incierto, el aislamiento o la impostura; 2) la familia, el hogar y el espacio poético, donde se analizan las figuras de los padres y de las madres y las figuras de los abuelos y de las abuelas —algunas con nombre propio—, la búsqueda del hogar y la configuración del espacio poético; 3) el dolor, la enfermedad y la muerte individual o colectiva, donde se consideran enfermedades como el cáncer, el Alzheimer o la demencia senil y se da cuenta la muerte individual a través del suicidio y de la muerte colectiva a través de las tragedias contemporáneas y de las fantasías del apocalipsis; 4) el desarrollo de la poética queer, donde se observa una tendencia marcada por la homosexualidad reprimida y otra tendencia marcada por la homosexualidad normalizada; y 5) la mirada de la mujer en el discurso poético, donde surgen motivos tan sugerentes como el feminismo, la sexualidad femenina volcada en el deseo, la posesión, la masturbación y los gustos sexuales o la maternidad narrada, reclamada o rechazada. Finalmente, en las conclusiones se presenta una nómina temática y una nómina tocante a las actitudes —acumulativa o combativa— y a las vertientes —sucesión y secesión frente a superposición y contraposición— localizadas entre los componentes de la Generación Reset.