bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the MMI Symani® Robotic Microsurgical System for coronary-bypass anastomoses in a cadaveric porcine model
Authors: Rusch Melanie , Hoffmann Grischa , Wieker Henning , Bürger Matthias , Kapahnke Sebastian , Berndt Rouven , Rusch René 
Published: February 2024

Abstract
Objective The MMI Symani® is a recently approved robotic microsurgical system for surgical procedures in adults. The system enables the surgeon to create microanastomoses. Clinical applications so far include lymphatic vessels surgery and the creation of special flap plastics. The use of the system in coronary arteries has not yet been assessed. The aim of this preclinical study was to evaluate the applicability of the Symani® surgical system in the creation of coronary anastomoses a cadaveric porcine model.Design and Methods A total of 12 anastomoses were performed by three senior cardiovascular surgeons on the left main coronary artery of three porcine hearts. Artificial bypasses (diameter 1 mm) were performed to the left main trunk. The anastomoses were performed with the Symani® surgical system. Evaluation included procedure times and anastomosis leakage.Results All anastomoses could be successfully performed. The procedure time decreased due to the learning curve between the first anastomosis 47:28 ± 5:30 min and the last anastomosis 22:37 ± 3:25 min. The final evaluation of the anastomoses showed excellent results with low leakage. The quality of the anastomosis also improved in relation to the increasing learning curve.Conclusion The Symani® surgical system could be used to create coronary anastomoses in an acceptable time frame and without technical failures. Hence, the system appears feasible for conventional coronary surgery. Further studies in animal models are mandatory prior to clinical application.
A Survey on Multi-modal Emotion Detection Techniques
Authors: Chatterjee Chintan , Shah Nihir , Bhatt Sahil , Chandi Smit 
Published: February 2024

Abstract

The utilization of emotion detection and recognition technologies has revolution- ized human-computer interactions in various fields such as sentiment analysis, health monitoring, education, and automotive interfaces. Previously, traditional systems relied on single-channel affect sensing, which limited their ability to cap- ture the complexity of human emotions. However, humans naturally combine multiple cues such as facial expressions, speech, gestures, and contextual factors when expressing their emotions. As a result, there has been a growing inter- est in multi-modal emotion frameworks that integrate different sensory streams to obtain more comprehensive emotion assessments. These holistic perspectives allow for the capture of nuanced affective information that would otherwise be difficult to represent. In this survey paper, we delve into the latest advancements in emotion recognition systems, examining fusion techniques, feature engineer- ing methods, and classification architectures that leverage inputs from various modalities such as vision, audio, and text. Our focus is to showcase innova- tive interventions throughout the entire pipeline, from preprocessing raw signals to predicting emotion labels, in order to enable robust multi-modal analysis. Through detailed theoretical discussions and practical case studies, this paper aims to inspire further research by providing insights into the current state-of- the-art, highlighting open challenges, and exploring promising avenues in emotion detection through cross-modal learning.
Comparison of Ventricular and Atrial Geometry and Functions in Dialysis Patients
Authors: Isler Aysenur Ceylan , Kaya Cansin Tulunay , Akbulut Muge , Kumru Gizem , Eren Sayeste Akkan , Sengul Sule , Ates Kenan , Kutlay Sim 
Published: February 2024

Abstract
Purpose
There are few studies comparing echocardiography in patients on peritoneal dialysis (PD) and hemodialysis (HD) although, comparison of cardiac changes between the two groups provides important prognostic information.
Methods
In 47 PD and 58 HD patients with no known cardiovascular disease, we performed pulse wave Doppler, tissue Doppler and speckle tracking echocardiography. We studied HD patients both before and after HD.
Results
Mitral E, mitral E/A, medial e', lateral e', mean E/e', tricuspid E/A, tricuspid s', tricuspid e', and tricuspid annular plane systolic excursion (TAPSE) were lower in PD patients compared to HD patients before HD (p:0.000, p:0.000, p:0.001, p:0.032, p:0.008, p:0.000, p:0.027, p:0.028, p:0.002, respectively). Medial a’, tricuspid E, tricuspid A, tricuspid DT, and TAPSE were significantly higher in PD patients compared to HD patients after HD (p = 0.02, p = 0.009, p = 0.023 and p = 0.001, respectively). GLS LV, LAVmax, LAVmin, and LAVI levels after HD were lower compared to levels seen in PD patients (p:0.001, p:0.000, p:0.041, p:0.000, respectively). In HD patients, mitral E, mitral A, mitral E/A, medial e', mean E/e', tricuspid E, tricuspid E/A, tricuspid e', tricuspid a', and TAPSE decreased after HD (p:0.000, p:0.000, p:0.001, p:0.001, p:0.000, p:0.000, p:0.000, p:0.000, p:0.021, p:0.000, respectively). Deterioration was observed in GLS-LV, GLS-RV, FWS-RV, SR, and S-CD after HD (p:0.000, p:0.000, p:0.000, p:0.030, p:0.002, respectively).
Conclusion
Strain values worsen both in PD and HD patients. HD deteriorates systolic and diastolic functions. The negative effect of dialysis on systolic function is higher in HD compared to PD.
The zebrafish gut microbiome influences benzo[a]pyrene developmental neurotoxicity
Authors: Stagaman Keaton , Alexiev Alexandra , Sieler Michael , Hammer Austin , Kasschau Kristin D. , Truong Lisa , Tanguay Robyn L. , Sharpton Thomas J. 
Published: February 2024

Abstract
Early-life exposure to environmental toxicants like Benzo[a]pyrene (BaP) is associated with several health consequences in vertebrates (i.e., impaired or altered neurophysiological and behavioral development). Although toxicant impacts were initially studied relative to host physiology, recent studies suggest that the gut microbiome is a possible target and/or mediator of behavioral responses to chemical exposure in organisms, via the gut-brain axis. However, the connection between BaP exposure, gut microbiota, and developmental neurotoxicity remains understudied. Using a zebrafish model, we determined whether the gut microbiome influences BaP impacts on behavior development. Embryonic zebrafish were treated with increasing concentrations of BaP and allowed to grow to the larval life stage, during which they underwent behavioral testing and intestinal dissection for gut microbiome profiling via high-throughput sequencing. We found that exposure affected larval zebrafish microbiome diversity and composition in a manner tied to behavioral development: increasing concentrations of BaP were associated with increased taxonomic diversity, exposure was associated with unweighted UniFrac distance, and microbiome diversity and exposure predicted larval behavior. Further, a gnotobiotic zebrafish experiment clarified whether microbiome presence was associated with BaP exposure response and behavioral changes. We found that gut microbiome state altered the relationship between BaP exposure concentration and behavioral response. These results support the idea that the zebrafish gut microbiome is a determinant of the developmental neurotoxicity that results from chemical exposure.
Inhibition of Epsilon Toxin-Producing Clostridium perfringens with a Juice-Based Probiotic Medical Food for Dietary Management of Multiple Sclerosis
Authors: Kamarei A. Reza , Robins Howard F. , Finkelstein Eric 
Published: February 2024

Abstract
Background
Multiple sclerosis (MS) is the most common disabling neurological disease in young adults, with symptom onset generally occurring between the ages of 20 and 40 years. Worldwide, there are 2.8 million people with MS, and in the United States, nearly 1 million. Currently, nine oral medications are FDA-approved for MS, each of which has its own undesirable side effects. The root cause of MS remains unknown, but epsilon toxin-producing C. perfringens is implicated as the trigger. Proving this trigger requires the ability to eliminate the bacteria or their toxic effect. As an element of the gut microbiome, epsilon toxin-producing C. perfringens may be managed through dietary interventions, but there is no specific dietary supplement or medical food currently available for this purpose.
Materials and Methods
The aim of this in vitro research project was to develop a juice-based probiotic medical food for the dietary management of multiple sclerosis by inhibiting the growth of epsilon toxin-producing C. perfringens.
For the probiotics, we used a proprietary blend of five strains of Bifidobacteriumand ten strains of Lactobacillus (“Doctor’s Biome Signature Probiotic Blend”). For the excipient, we used a proprietary blend of organic green fruit and vegetable juices. The probiotics were added to sterilized excipient at 60 billion colony-forming units per two fluid ounces, yielding a medical food for multiple sclerosis (MF-MS). Two strains of epsilon toxin-producing C. perfringens, ATCC 3626 (type B) and ATCC 3631 (type D), were used as the target microorganisms.
Results
Over six days of culture, the control samples (RCM broth) showed drastic population growth of both strains, while the test samples (MF-MS) demonstrated complete inhibition of growth for both strains of epsilon toxin-producing Clostridium perfringens.
Conclusion
We have developed a patent-pending, juice-based probiotic medical food for the dietary management of MS that inhibits the growth of both type B and type D epsilon toxin-producing Clostridium perfringens, which, according to the most recent published clinical findings, are thought to be the cause or trigger of MS. To our knowledge, this is the first in vitro study in which such an effect has been clearly demonstrated.
The Role of Nurses, Midwives, and Doulas in Breastfeeding Education and Rates: Changes During the COVID-19 Pandemic
Authors: Dhaurali Shubhecchha , Shrestha Shikhar 
Published: February 2024

Abstract
Background The COVID-19 pandemic has significantly altered maternal healthcare delivery, including breastfeeding practices. Our study investigated the influence of nurses, midwives, and doulas on breastfeeding education and rates, with a specific focus on changes that transpired during the COVID-19 pandemic.Methods Using a cross-sectional design, we performed a secondary data analysis on a stratified systematic sample of forty-six U.S. states and New York City respondents who completed the Pregnancy Risk Assessment Monitoring System (PRAMS) Phase 7 (2012–2015) and Phase 8 (2016–2020) surveys (n = 193,068). Descriptive analyses and adjusted multivariable logistic regression models reporting adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were used to assess associations between the provision of breastfeeding guidance to mothers from nurses, doulas, or midwife healthcare professionals; breastfeeding/pumping rates; and the COVID-19 pandemic.Results Our findings revealed that participants who received breastfeeding guidance from nurses, midwives, or doulas were twice as likely to have engaged in breastfeeding or milk pumping for their infants than participants who did not receive breastfeeding education (aOR = 1.99, 95% CI: 1.89–2.11, p ≤ 0.0001). Additionally, participants who gave birth during the COVID-19 pandemic were notably less likely to receive breastfeeding education from a nurse, midwife, or doula than were those who gave birth before the pandemic (aOR = 0.92, 95% CI: 0.88–0.96, p ≤ 0.0001).Conclusion Our study underscores the vital role that healthcare professionals play in educating, advocating for, and promoting breastfeeding behaviors. This further highlights the pressing need for sustained efforts to support breastfeeding initiatives and address disparities in maternal and child health, particularly in the context of the challenges presented by the COVID-19 pandemic.
Elevated heterotrophic activity in hydrothermal plumes influences deep-sea carbon cycling
Authors: Joye Samantha , Montgomery Andrew , Zhuang Guang-Chao , Zhou Zhichao , Marinelli Zachary , Choi Hannah , Hunter Kimberly , Anantharaman Karthik , Teske Andreas 
Published: February 2024

Abstract
Hydrothermal plumes are deep-sea extreme environments that support dynamic microbial metabolisms. Chemoautotrophic production coupled to the oxidation of reduced energy-laden substrates has been considered the primary metabolism in plumes. Recently, sequencing data suggested organic carbon cycling may also be important. However, the biogeochemical fate of organic carbon in hydrothermal plumes remains unconstrained. Here, we used an interdisciplinary approach to investigate the metabolisms of a suite of organic substrates and constrain the impacts of hydrothermal plumes on deep-sea carbon cycling. Acetate and methanol were detected throughout the water column, and both were rapidly metabolized in the Guaymas Basin. Heterotrophic production rates from acetate and methanol, up to 7.69 µg C L-1 d-1, greatly exceeded chemoautotrophic production, often by orders of magnitude. Functional genes encoding enzymes associated with heterotrophic production, such as acetyl-CoA or citrate synthetases, were abundant throughout Guaymas Basin, demonstrating the influence of hydrothermal inputs on deep-sea microbiology. Elevated rates of microbial activity coincided with a distinct plume signature, indicating that microbial communities quickly responded to hydrothermal inputs. Our results illustrated that organic carbon is differentially cycled within hydrothermal plumes, suggesting that heterotrophic production near hydrothermal vents may profoundly impact metabolic activity and carbon cycling in these deep-sea habitats.
Regional downscaling of CMIP6 climate projections for the Vancouver coastline
Authors: Kristiansen Trond , Miller Jordan , Makonnen Samuel 
Published: February 2024

Abstract
This report contains enhanced resolution climate projections of ocean temperature for the Vancouver coastline.
The projections in this report rely on assumptions of future carbon outputs, multiple 3rd party models with their own assumptions, and further downscaling assumptions. Actea includes metrics of climate model variance in this report, to help users understand the uncertainties in these projections. As with any forward-looking projections, this report is not a guarantee of future outcomes and undue reliance should not be placed on it. Forward-looking projections necessarily involve known and unknown risks and uncertainties, which may cause actual climate outcomes to differ materially from the projections within this report.
Study about Physical and Mechanical Properties of Hybrid Fiber Reinforced Self-Compacting Concrete (HYRSCC)
Authors: Sowmya S , Jeyaseela J , Hameed Shahul 
Published: February 2024

Abstract
This study is relative exploratory on property study on self-compacting concrete with hybrid fiber under pressure and split tractable stacking. The shape compressive strength and chamber split rigidity of regular concrete and half breed fiber built up not set in stone in the lab. The M35grade of substantial blend and mono fiber of length 120mm for volume portion of 0.0%, 0.25%, 0.5% and pleated steel fiber of length 13mm and its width 0.25mm at volume of 0.0%, 0.25%, 0.5% and adding a mineral admixture silica flour were utilized in the exploration. Every one of the examples were tried at restoring period of 7days and 28 days. It was proposed to concentrate on the compressive strength, split elasticity for all examples with various blends and different level of strand.
The Relationship of Cerebrospinal Fluid Biomarkers and Cognitive Performance in Frontotemporal Dementia
Authors: Cayir Salih , Sadabad Faranak Ebrahimian , Mecca Adam , Matuskey David , Zadeh Arman Fesharaki 
Published: February 2024

Abstract

Objective: Currently available literature on the relationships between cerebrospinal fluid (CSF) biomarkers and cognitive performance in frontotemporal dementia (FTD) is very limited and inconclusive. In this study, we investigated the association of cognition, as measured with Montreal Cognitive Assessment (MoCA), with CSF levels of total tau (t-tau), phosphorylated tau at threonine 181 (p-tau181), and amyloid β 1–42 (Aβ1–42) in a group of patients with FTD and Alzheimer’s disease (AD).
Methods: We conducted a retrospective cohort study with participants selected from the electronic records of patients seen at Yale New Haven Hospital’s Memory Clinic, CT, USA. We included 61 patients, 28 with FTD (mean age=64.1) and 33 with AD (mean age=66.8).
Results: T-tau levels negatively and significantly correlated with total MoCA scores as well as the different MoCA index scores in both the FTD (r=-0.469, p<0.05) and AD (r=-0.545, p<0.01) groups. There were no significant associations with MoCA scores and p-tau181 levels in patients with FTD (r=-0.224, p>0.05), unlike patients with AD, who exhibited significant correlations (r=-0.549, p<0.01). Also, Aβ1–42 levels were not significantly correlated with MoCA scores in either of the FTD and AD groups.
Conclusion: CSF concentrations of t-tau are inversely correlated to cognitive performance in patients with FTD and both t-tau and p-tau181 in AD. These findings provide valuable insights into the relationship between clinical cognitive performance and tau-related pathology in FTD.
Modeling of the viscoelastic behavior of polymer-modified asphalts
Authors: Medina-Torres Luis , Núñez-Ramírez Diola Marina , González-Laredo Rubén Francisco , González-Lozano Miguel Angel , Alonso Salvador , Zitzumbo Roberto , Gallegos-Infante José Alberto 
Published: February 2024

Abstract
An analysis and modelling of the linear viscoelastic behavior of maltenes (M) blended with styrene-butadiene-styrene block copolymer (SBS) are presented in this study. M were mixed with different amounts of SBS (Elastomer, E) (0.25 to 80 wt.%) to investigate the effect of polymer concentration on linear viscoelastic response of the blends; storage and loss moduli were obtained from small amplitude oscillatory shear tests (SAOS). Time-temperature superposition master curves were analyzed by a Maxwell multimodal model with up to nine relaxation times. Han, Cole-Cole and Van Gurp-Palmen diagrams were prepared from the rheological data. Two different responses were observed: At low E contents, a dispersed system rheological response was observed and verified by microscopy with elastomer as the dispersed phase and maltenes as the matrix, while at high E content the response was that of a co-continuous system. Mixtures with E > 2 wt % exhibited change in their thermomechanical properties with a phase inversion at E > 50 wt. %. Furthermore, at low E concentration resins stabilize the dispersed phase by diminishing the magnitude of the viscoelastic moduli, conversely, at high E concentration a swelled polymer-rich phase creates a network that significantly influences of the viscoelastic properties.
Unpacking the Nexus between Climate Change and Maize Production in Nigeria: A Bound Test Approach to Integration
Authors: Ajala Seun Boluwatife , Chagwiza Clarietta 
Published: February 2024

Abstract

The dilemma of decreasing agricultural production in the face of rapid population growth in Nigeria is being made worse by the growing threat of climate change. This suggests that food security and rural sustainability are at risk. Given that various crops have varying climate needs, specific crop analyses are necessary. This study therefore used time-series data between 1979 and 2020 to examine the connection between climate change and maize production in Oyo State, Nigeria. The relevant data were collected and analyzed using a bound testing (autoregressive distributed lag) approach. The results confirmed the long-term equilibrium between maize yield and temperature, rainfall, and relative humidity. The results revealed that climatic variables are vital to maize productivity in Oyo State and Nigeria. Therefore, the findings are relevant for designing coping interventions (long-term and short-term) to address the impact of climate change on maize yield in Oyo State and Nigeria overall.
¿Cuál es el alcance del artículo 7.1.k del estatuto de roma que consagra como crimen de lesa humanidad otros actos inhumanos en relación con el principio de legalidad en Colombia?
Authors: Ochoa Arias Jonathan , Rodriguez Urrego Carlos Andres , Sepulveda William Andres 
Published: February 2024

El presente trabajo investigativo tiene como objeto central, la exposición clara e íntegra del marco que envuelve los denominados Delitos de lesa humanidad, así como su influencia en el desarrollo del derecho penal internacional, tanto en la doctrina como la jurisprudencia; para poder analizar el texto del Art. 7 núm. 1 Literal K. Para ello, el trabajo se reparte en un estudio del contexto histórico y, los hechos más relevantes que contribuyeron al desarrollo de estos tipos penales. También se hace un análisis del delito de lesa humanidad, así como de sus elementos. Debido a la importancia que tiene para la cultura jurídica occidental el principio de legalidad y de tipicidad; y por su influencia en la formación del tipo penal internacional, también se realizan exámenes del mismo, para contrastar mejor la temática con la problemática. Finalmente se expone la propuesta central de los investigadores, con las cual se motiva la razón de ser del trabajo investigativo; y lo que busca el mismo.
Viral MicroRNAs in Herpes Simplex Virus 1 Pathobiology
Authors: Naqvi Raza Ali , Valverde Araceli , Yadavalli Tejabhiram , Bobat Fatima Ismail , Capistrano Kristelle J. , Shukla Deepak , Naqvi Afsar R. 
Published: February 2024

Abstract:
Simplexvirus humanalpha1 (Herpes simplex virus type 1 [HSV-1]) infects millions of people globally,
manifesting as vesiculo-ulcerative lesions of the oral or genital mucosa. After primary infection, the virus
establishes latency in the peripheral neurons and reactivates sporadically in response to various environmental
and genetic factors. A unique feature of herpesviruses is their ability to encode tiny noncoding RNAs called
microRNA (miRNAs). Simplexvirus humanalpha1 encodes eighteen miRNA precursors that generate twentyseven
different mature miRNA sequences. Unique Simplexvirus humanalpha1 miRNAs repertoire is expressed
in lytic and latent stages and exhibits expressional disparity in various cell types and model systems, suggesting
their key pathological functions. This review will focus on elucidating the mechanisms underlying the regulation
of host-virus interaction by HSV-1 encoded viral miRNAs. Numerous studies have demonstrated sequence-
specific targeting of both viral and host transcripts by Simplexvirus humanalpha1 miRNAs. While these
noncoding RNAs predominantly target viral genes involved in viral life cycle switch, they regulate host
genes involved in antiviral immunity, thereby facilitating viral evasion and lifelong viral persistence inside the
host. Expression of Simplexvirus humanalpha1 miRNAs has been associated with disease progression and resolution.
Systemic circulation and stability of viral miRNAs compared to viral mRNAs can be harnessed to utilize
their potential as diagnostic and prognostic markers. Moreover, functional inhibition of these enigmatic
molecules may allow us to devise strategies that have therapeutic significance to contain Simplexvirus humanalpha1
infection.