bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foot Strike Run Retraining for Patients With Patellofemoral Chondral Defects: A Case Series
Authors: Pontillo Marisa , Mazzone Gunterstockman Brittney , Bunn Adam , Bechard Laura , Wolfgramm Sione , Mack Takman , Farrokhi Shawn 
Published: November 2023

ABSTRACT
Military service members (SMs) demonstrate high rates of patellofemoral chondral defects (PFCDs) that are difficult to diagnosis and, if untreated, result in a cascade of events eventually leading to osteoarthritis. Running is an essential occupational task for SMs; however, there is little evidence regarding techniques to maintain running ability in individuals with cartilage defects. The purpose of this case series was to assess the clinical application of foot strike run retraining in patients with PFCDs. This case series included two active duty U.S. Marine Corps SMs who presented to outpatient physical therapy with PFCD, diagnosed via MRI. Both patients attended eight foot strike run retraining sessions. Running mechanics and patient-reported outcomes were recorded pre-training, post-training, and at a 1-month follow-up visit. Both patients successfully converted their strike pattern from a rearfoot to a non-rearfoot strike pattern with training and retained this strategy at 1-month follow-up. Post-intervention, both patients demonstrated increased running tolerance, and improvements in Numeric Pain Rating Scale and Lower Extremity Functional Scale scores. Biomechanical analysis showed that both patients demonstrated a 63% to 70% reduction in average and peak vertical ground reaction force loading rates post-treatment. Modification of foot strike pattern from rear to non-rearfoot strike during running for individuals with PFCD can reduce the magnitude of impact loading, which potentially limits disease progression. These findings suggest that foot strike run retraining may be a feasible strategy to reduce pain and improve function in SMs with PFCD who are required to run for occupational responsibilities.
Shock-driven periodic variability in a low-mass-ratio supermassive black hole binary
Authors: Whitley K , Kuznetsova A , Gültekin K , Ruszkowski M 
Published: November 2023

ABSTRACT
We investigate the time-varying electromagnetic emission of a low-mass-ratio supermassive black hole binary (SMBHB) embedded in a circumprimary disc, with a particular interest in variability of shocks driven by the binary. We perform a 2D, locally isothermal hydrodynamics simulation of an SMBHB with mass ratio q = 0.01 and separation a = 100 Rg, using a physically self-consistent steady disc model. We estimate the electromagnetic variability from the system by monitoring accretion on to the secondary and using an artificial viscosity scheme to capture shocks and monitor the energy dissipated. The SMBHB produces a wide, eccentric gap in the disc, previously only observed for larger mass ratios, which we attribute to our disc model being much thinner (H/R ≈ 0.01 near the secondary) than is typical of previous works. The eccentric gap drives periodic accretion on to the secondary SMBH on a time-scale matching the orbital period of the binary, $t_{\rm {bin}}\approx 0.1\,\,\rm {yr}$, implying that the variable accretion regime of the SMBHB parameter space extends to lower mass ratios than previously established. Shocks driven by the binary are periodic, with a period matching the orbital period, and the shocks are correlated with the accretion rate, with peaks in the shock luminosity lagging peaks in the accretion rate by 0.43 tbin. We propose that the correlation of these quantities represents a useful identifier of SMBHB candidates, via observations of correlated variability in X-ray and ultraviolet monitoring of active galactic nuclei, rather than single-waveband periodicity alone.
Deleterious and Adaptive Mutations in Plant Germplasm Conserved Ex Situ
Authors: Fu Yong-Bi , Peterson Gregory W , Horbach Carolee 
Published: November 2023

Abstract
Conserving more than 7 million plant germplasm accessions in 1,750 genebanks worldwide raises the hope of securing the food supply for humanity for future generations. However, there is a genetic cost for such long-term germplasm conservation, which has been largely unaccounted for before. We investigated the extent and variation of deleterious and adaptive mutations in 490 individual plants representing barley, wheat, oat, soybean, maize, rapa, and sunflower collections in a seed genebank using RNA-Seq technology. These collections were found to have a range of deleterious mutations detected from 125 (maize) to 83,695 (oat) with a mean of 13,537 and of the averaged sample-wise mutation burden per deleterious locus from 0.069 to 0.357 with a mean of 0.200. Soybean and sunflower collections showed that accessions acquired earlier had increased mutation burdens. The germplasm with more years of storage in several collections carried more deleterious and fewer adaptive mutations. The samples with more cycles of germplasm regeneration revealed fewer deleterious and more adaptive mutations. These findings are significant for understanding mutational dynamics and genetic cost in conserved germplasm and have implications for long-term germplasm management and conservation.
Genetic variations in G-quadruplex forming sequences affect the transcription of human disease-related genes
Authors: Lorenzatti Agustín , Piga Ernesto J , Gismondi Mauro , Binolfi Andrés , Margarit Ezequiel , Calcaterra Nora B , Armas Pablo 
Published: November 2023

Abstract
Guanine-rich DNA strands can fold into non-canonical four-stranded secondary structures named G-quadruplexes (G4s). G4s folded in proximal promoter regions (PPR) are associated either with positive or negative transcriptional regulation. Given that single nucleotide variants (SNVs) affecting G4 folding (G4-Vars) may alter gene transcription, and that SNVs are associated with the human diseases’ onset, we undertook a novel comprehensive study of the G4-Vars genome-wide (G4-variome) to find disease-associated G4-Vars located into PPRs. We developed a bioinformatics strategy to find disease-related SNVs located into PPRs simultaneously overlapping with putative G4-forming sequences (PQSs). We studied five G4-Vars disturbing in vitro the folding and stability of the G4s located into PPRs, which had been formerly associated with sporadic Alzheimer's disease (GRIN2B), a severe familiar coagulopathy (F7), atopic dermatitis (CSF2), myocardial infarction (SIRT1) and deafness (LHFPL5). Results obtained in cultured cells for these five G4-Vars suggest that the changes in the G4s affect the transcription, potentially contributing to the development of the mentioned diseases. Collectively, data reinforce the general idea that G4-Vars may impact on the different susceptibilities to human genetic diseases’ onset, and could be novel targets for diagnosis and drug design in precision medicine.
jMorp: Japanese Multi-Omics Reference Panel update report 2023
Authors: Tadaka Shu , Kawashima Junko , Hishinuma Eiji , Saito Sakae , Okamura Yasunobu , Otsuki Akihito , Kojima Kaname , Komaki Shohei , Aoki Yuichi , Kanno Takanari , Saigusa Daisuke , Inoue Jin , Shirota Matsuyuki , Takayama Jun , Katsuoka Fumiki , Shimizu Atsushi , Tamiya Gen , Shimizu Ritsuko , Hiratsuka Masahiro , Motoike Ikuko N , Koshiba Seizo , Sasaki Makoto , Yamamoto Masayuki , Kinoshita Kengo 
Published: November 2023

Abstract
Modern medicine is increasingly focused on personalized medicine, and multi-omics data is crucial in understanding biological phenomena and disease mechanisms. Each ethnic group has its unique genetic background with specific genomic variations influencing disease risk and drug response. Therefore, multi-omics data from specific ethnic populations are essential for the effective implementation of personalized medicine. Various prospective cohort studies, such as the UK Biobank, All of Us and Lifelines, have been conducted worldwide. The Tohoku Medical Megabank project was initiated after the Great East Japan Earthquake in 2011. It collects biological specimens and conducts genome and omics analyses to build a basis for personalized medicine. Summary statistical data from these analyses are available in the jMorp web database (https://jmorp.megabank.tohoku.ac.jp), which provides a multidimensional approach to the diversity of the Japanese population. jMorp was launched in 2015 as a public database for plasma metabolome and proteome analyses and has been continuously updated. The current update will significantly expand the scale of the data (metabolome, genome, transcriptome, and metagenome). In addition, the user interface and backend server implementations were rewritten to improve the connectivity between the items stored in jMorp. This paper provides an overview of the new version of the jMorp.
The P10K database: a data portal for the protist 10 000 genomes project
Authors: Gao Xinxin , Chen Kai , Xiong Jie , Zou Dong , Yang Fangdian , Ma Yingke , Jiang Chuanqi , Gao Xiaoxuan , Wang Guangying , Gu Siyu , Zhang Peng , Luo Shuai , Huang Kaiyao , Bao Yiming , Zhang Zhang , Ma Lina , Miao Wei 
Published: November 2023

Abstract
Protists, a highly diverse group of microscopic eukaryotic organisms distinct from fungi, animals and plants, exert crucial roles within the earth's biosphere. However, the genomes of only a small fraction of known protist species have been published and made publicly accessible. To address this constraint, the Protist 10 000 Genomes Project (P10K) was initiated, implementing a specialized pipeline for single-cell genome/transcriptome assembly, decontamination and annotation of protists. The resultant P10K database (https://ngdc.cncb.ac.cn/p10k/) serves as a comprehensive platform, collating and disseminating genome sequences and annotations from diverse protist groups. Currently, the P10K database has incorporated 2959 genomes and transcriptomes, including 1101 newly sequenced datasets by P10K and 1858 publicly available datasets. Notably, it covers 45% of the protist orders, with a significant representation (53% coverage) of ciliates, featuring nearly a thousand genomes/transcriptomes. Intriguingly, analysis of the unique codon table usage among ciliates has revealed differences compared to the NCBI taxonomy system, suggesting a need to revise the codon tables used for these species. Collectively, the P10K database serves as a valuable repository of genetic resources for protist research and aims to expand its collection by incorporating more sequenced data and advanced analysis tools to benefit protist studies worldwide.
Clathrate metal superhydrides under high-pressure conditions: enroute to room-temperature superconductivity
Authors: Sun Ying , Zhong Xin , Liu Hanyu , Ma Yanming 
Published: November 2023

ABSTRACT
Room-temperature superconductivity has been a long-held dream of mankind and a focus of considerable interest in the research field of superconductivity. Significant progress has recently been achieved in hydrogen-based superconductors found in superhydrides (hydrides with unexpectedly high hydrogen contents) that are stabilized under high-pressure conditions and are not capturable at ambient conditions. Of particular interest is the discovery of a class of best-ever-known superconductors in clathrate metal superhydrides that hold the record for high superconductivity (e.g. Tc = 250–260 K for LaH10) among known superconductors and have great promise to be those that realize the long-sought room-temperature superconductivity. In these peculiar clathrate superhydrides, hydrogen forms unusual ‘clathrate’ cages containing encaged metal atoms, of which such a kind was first reported in a calcium hexa-superhydride (CaH6) showing a measured high Tc of 215 K under a pressure of 170 GPa. In this review, we aim to offer an overview of the current status of research progress on the clathrate metal superhydride superconductors, discuss the superconducting mechanism and highlight the key features (e.g. structure motifs, bonding features, electronic structure, etc.) that govern the high-temperature superconductivity. Future research direction along this line to find room-temperature superconductors will be discussed.
The Interpretation of the Psalter
Authors: Gillingham S E 
Published: November 2023

Abstract
It goes without saying that the Hebrew text during this millennium must have undergone a process of change. One has only to compare duplicate psalms such as 14 and 53; 40:12-16 and 70; 108 and 57:7-11 along with 60:5-12; and Ps. 18 and 2 Sam. 22, to find evidence of a number of variations which existed even in the same Hebrew texts.
Psychosocial aspects of palliative care, and why they matter
Authors: Faull Christina , Woof Richard 
Published: November 2023

Abstract
Medicine is about both understanding illness and understanding people. Each aspect is vitally important if we want to be good doctors. However, our training concentrates on the necessity of mastering the complexity of disease and the array of technical skills we can utilize; this is also what we tend co get taught and examined on. What is more, we soon find that this is what can amaze and amuse our friends (see Recognizing a Graham Steele murmur on the patient in bed 12 and getting your patienr to tell you what was really terrifying him or her are both highly skilled jobs you could. do.. But which sounds the more impressive, and· why? Think point). However, this emphasis makes it harder to always see the value in considering the wider context of the disease experience for our patients.
Decisions around the end of life
Authors: Faull Christina , Woof Richard 
Published: November 2023

Abstract
There is nothing more certain than all our patients, all of us, will die one day, but unfortunately even for patients with advanced progressive illness the circumstances of death happen most often by default rather than by design. Doctors don’t always recognize or acknowledge when a patient is nearing the end of his or her life. We may focus on the immediate problems caused by the illness and its threat to life. ‘The treatment of a pulmonary embolus is .. .’. We may consider the need co relieve the distress caused by the physical symptoms, Tll give Mr Smith some diclofenac for the hip pain from his prostate cancer’. But how often do we take an overview of the whole situation; assess what has happened over the past weeks and months; find out what life has been like for the patient and their family; find out their views on how this illness episode should be managed? (See also Chapter 3.)
Fukuyama congenital muscular dystrophy
Authors: Saito Kayoko , Kobayashi Makio 
Published: November 2023

Abstract
The first report on 15 cases of Fukuyama congenital muscular dystrophy (FCMD) was published in 1960 entitled ‘A peculiar form of congenital progressive muscular dystrophy’ by Fukuyama et al. (1960). The majority of such patients reported at that time had been treated at other institutions under an incorrect diagnosis of cerebral palsy or multiple neurological handicaps. Fukuyama et al. explored a different diagnosis on the basis of the following: there was no sign of spasticity or increased muscle tone; deep tendon reflexes were absent or reduced; and, muscle resistance against passive movement was always reduced. The patients were submitted for electromyography, muscle biopsy with histochemical staining and analysis of serum creatine kinase (CK) activities, a method developed only in the late 1950s. From this, Fukuyama et al. (1960) clearly demonstrated that the skeletal muscle of these patients showed progressive muscular dystrophy.
The limb-girdle muscular dystrophies
Authors: Bushby Katharine M D 
Published: November 2023

Abstract
This lack of precision caused controversy which is reflected in the papers published throughout this period. The variability in descriptions of some large families with what could be described as a limb-girdle muscular dystrophy phenotype served to underline the ‘broad church’ that this represented and some authors proposed the adoption of the term ‘limb-girdle syndrome’ in recognition of this (Passos-Bueno et al. 1991). In the meantime, other authors proposed that the condition did not exist at all but that alternative diagnoses should be sought in every case in whom it was considered. These authors advocated that the term limb-girdle muscular dystrophy should be dropped altogether (Walton and Gardner-Medwin 1988; 1991). A further view came from those who preferred a more “pure” designation of LGMD to be applied to a much more clearly defined group of patients (Fardeau et al. 1996).
Mathematics for the Curious
Authors: Higgins Peter M 
Published: November 2023

Abstract
When do the hands of a clock coincide? How likely is it that two children in the same class will share a birthday? Should you play Roulette or the Lottery? How do we calculate the volume of a doughnut? Why does the android Data in Star Trek lose at poker? What is Fibonacci’s Rabbit Problem? Many things in the world have a mathematical side to them, as revealed by the puzzles and questions in this book. It is written for anyone who is curious about mathematics and would like a simple and entertaining account of what it can do. Peter Higgins provides clear explanations of the more mysterious features of childhood mathematics as well as novelties and connections to prove that mathematics can be enjoyable and full of surprises.
Music at Oxford in the Eighteenth and Nineteenth Centuries
Authors: Wollenberg Susan 
Published: November 2023

Abstract
This book is the first survey of its kind and distils a wide range of documentary and musical evidence relating to a particularly rich period in the history of the city of Oxford, embracing both 'town and gown'. The author, a Lecturer in Music in the university, discusses in detail, among other aspects, concert life in Oxford during the eighteenth and nineteenth centuries, when notable visitors to the city included Handel, Haydn, Liszt, and Joachim; the choral tradition; and developments in the university that led to the eventual establishment of an honour school of music. A brief outline of musical activity in Oxford before c.1660 and after c.1914 is also provided. In addition, the author examines the achievements of a number of individual musical personalities, drawing particular attention to the role of William Crotch, Frederick Ouseley, and Hubert Parry in raising the status of music and the music profession. The book makes an important contribution to a number of spheres of enquiry that have developed significantly in recent years: the history of universities, social history of music, and the study of concert life.
The Colleges, II
Authors: Wollenberg Susan 
Published: November 2023

Abstract
In the early nineteenth century, music could be woven in many ways into the daily lives of the college residents, as Egerton’s diary shows with reference to New College: [1826: 26 March, Sunday chapel]: Bennett is an admirable organist & has improved the Choristers wonderfully. [29 March]: … Dined in Hall-at seven went to … a Practising Fiddling Party. Young Reinagle led: a very clever Fellow. He plays the Violin & Violoncello capitally.
Epilogue: The Tradition after c.I9I4
Authors: Wollenberg Susan 
Published: November 2023

Abstract
In the years of the First World War, ‘the role of music was intensified (though its practitioners were diminished in number)’; one commentator in the local press in Oxford observed that ‘among the by products of war time must be reckoned the impulse it lends to art, literature and music’.’ Another comment to the effect that ‘the exigencies of war time’ had ‘deprived … the present generation’ of the experience of large choral performances alluded to the Oxford Bach Choir as an exception. ‘The particular occasion was 25 February 1915, at the Sheldonian Theatre, when Hugh Allen conducted a concert “in memory of those who have fallen in the war”.’ Included in the programme was Parry’s The Glories of our Blood and State (originally composed in 1883).
Subject to Change
Authors: Boyle Deirdre 
Published: November 2023

Abstract
The summer of 1969 was extraordinarily eventful. In July American astronauts were the first men to walk on the moon, and video pioneers watched the fuzzy black-and-white video of the lunar landing, finding exciting confirmation of Buckminster Fuller’s theory that we are evolving through our technology. Michael Shamberg, who watched the broadcasts along with millions around the globe, experienced a great epiphany.
Gaga Over Guru
Authors: Boyle Deirdre 
Published: November 2023

Abstract
TVTV effectively abandoned all claims of being an alternate video group when they decided to re-edit the convention tapes for broadcast on Westinghouse television stations. As Allen Rucker later recalled, “We broke the sacred rule: our friend Paul Ryan’s dictum that VT (videotape) is not TV, that alternative TV does not truck with broadcast.” TVTV knew that many in the alternative video movement believed the group had sold out, but TVTV had learned the hard way that cable television was not interested in funding original programming.
Prime Time TVTV
Authors: Boyle Deirdre 
Published: November 2023

Abstract
Soon after the Presidential Nominating Conventions, Allen Rucker of TVTV and Alvin Duskin, a millionaire clothing manufacturer turned political and media activist, began work on a tape about the people behind television commercials. The idea was in keeping with TVTV’s interest in exposing the inner workings of the television industry. Duskin’s San Francisco group, Public Interest Communications, was involved in counteradvertising and was to have produced the program with TVTV. But when Public Interest Communications proved unwilling to provide full funding for the tape, TVTV severed their ties and decided to produce it themselves.
Changing Channels
Authors: Boyle Deirdre 
Published: November 2023

Abstract
Although some felt “Communitube” would have been a better title for University Community Video’s biweekly series, it was “Changing Channels” that premiered Wednesday, October 9, 1974. Getting Minneapolis’ PBS affiliate KTCA to accept the idea of a regular series took long hours of negotiations, partly because of technical obstacles and partly because the programs would not have the sophisticated look of broadcast television. A compromise was struck when UCV agreed to comply with the FCC requirements for color burst, borrowing the strategy TVTV had used with Lord of the Universe by inserting color graphics throughout their black-and-white program.
lntermedia
Authors: Boyle Deirdre 
Published: November 2023

Abstract
After years of calling themselves an alternative video magazine, the producers of “Changing Channels” began to suffer from a peculiar form of anxiety that comes from not knowing what you are, only what you are not. According to Stephen Kulczycki, it had worked only as long as they were immersed in the culture that had formed them. But in the late ’70s, baby boomers who grew up wanting to believe they were something more complex than the 7-Up Generation discovered they were buying a hell of a lot of 7-Up. One day they woke up thinking, “Dammit, I deserve more than three or four minutes a show. I’m not going to do all this work for just a four-minute piece. I could make a ten-minute or a twenty-minute or a two-hour piece.”
On the Use of Variables
Authors: Tarski Alfred 
Published: November 2023

Abstract
Every scientific theory is a system of sentences which are accepted as true and which may be called LAWS or ASSERTED STATEMENTS (sometimes one says, for short, simply STATEMENTS). In mathematics these statements follow one another in a definite order, and in accordance with certain principles which will be discussed in detail in Chapter VI; in view of these principles, the statements are generally accompanied by arguments whose purpose is to demonstrate their truth. Arguments of this kind are referred to as PROOFS, and the statements established by them are called THEO¬REMS.