bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the self-interaction of dark matter through central cluster galaxy offsets
Authors: Cross D , Thoron G , Jeltema T E , Swart A , Hollowood D L , Adhikari S , Bocquet S , Eiger O , Everett S , Jobel J , Laubner D , McDaniel A , Aguena M , Alves O , Andrade-Oliveira F , Bacon D , Bertin E , Brooks D , Burke D L , Carnero Rosell A , Carrasco Kind M , Cawthon R , Costanzi M , da Costa L N , Pereira M E S , Davis T M , Desai S , Doel P , Ferrero I , Frieman J , García-Bellido J , Giannini G , Gruen D , Gruendl R A , Hinton S R , Honscheid K , James D J , Kuehn K , Marshall J L , Mena-Fernández J , Menanteau F , Miquel R , Ogando R L C , Pieres A , Plazas Malagón A A , Raveri M , Romer A K , Sanchez E , Sevilla-Noarbe I , Smith M , Soares-Santos M , Sobreira F , Suchyta E , Swanson M E C , Tarle G , To C , Weaverdyck N , Weller J , Wiseman P ,   (DES Collaboration)
Published: February 2024

ABSTRACT
While collisionless cold dark matter models have been largely successful in explaining a wide range of observational data, some tensions still exist, and it remains possible that dark matter possesses a non-negligible level of self-interactions. In this paper, we investigate a possible observable consequence of self-interacting dark matter: offsets between the central galaxy and the centre of mass of its parent halo. We examine 23 relaxed galaxy clusters in a redshift range of 0.1–0.3 drawn from clusters in the Dark Energy Survey and the Sloan Digital Sky Survey which have archival Chandra X-ray data of sufficient depth for centre and relaxation determination. We find that most clusters in our sample show non-zero offsets between the X-ray centre, taken to be the centroid within the cluster core, and the central galaxy position. All of the measured offsets are larger, typically by an order of magnitude, than the uncertainty in the X-ray position due to Poisson noise. In all but six clusters, the measured offsets are also larger than the estimated, combined astrometric uncertainties in the X-ray and optical positions. A more conservative cut on concentration to select relaxed clusters marginally reduces but does not eliminate the observed offset. With our more conservative sample, we find an estimated median X-ray to central galaxy offset of $\mu = 6.0 ^{+ 1.4}_{- 1.5}$ kpc. Comparing to recent simulations, this distribution of offsets is consistent with some level of dark matter self-interaction, though further simulation work is needed to place constraints.
Classical Cepheid pulsation properties in the Rubin-LSST filters
Authors: De Somma Giulia , Marconi Marcella , Cassisi Santi , Molinaro Roberto , Bhardwaj Anupam , Ripepi Vincenzo , Musella Ilaria , Pietrinferni Adriano , Sicignano Teresa , Trentin Erasmo , Leccia Silvio 
Published: February 2024

ABSTRACT
Homogeneous multiwavelength observations of classical Cepheids from the forthcoming Rubin-LSST have the potential to significantly contribute to our understanding of the evolutionary and pulsation properties of these pulsating stars. Updated pulsation models for classical Cepheid stars have been computed under various assumptions about chemical compositions, including relatively low metallicity (Z = 0.004 with Y = 0.25 and Z = 0.008 with Y = 0.25), solar metallicity (Z = 0.02 with Y = 0.28), and supersolar metallicity environments (Z = 0.03 with Y = 0.28). From the predicted periods, intensity-weighted mean magnitudes, and colours, we have derived the first theoretical pulsation relations in the Rubin-LSST filters (ugrizy), including period–luminosity–colour, period–Wesenheit, and period–age–colour relations. We find that the coefficients of these relations are almost insensitive to the efficiency of superadiabatic convection but are significantly affected by the assumption of the mass–luminosity relation and the adopted chemical composition. Metal-dependent versions of these relations are also derived, representing valuable tools for individual distance determinations and correction for metallicity effects on the cosmic distance scale.
The Kormendy relation of cluster galaxies in PPS regions
Authors: Ribeiro A L B , Lopes P A A , Morell D F , Dantas C C , Fonseca M H S , Amarante B G , Morais-Neto F R 
Published: February 2024

ABSTRACT
We study a sample of 936 early-type galaxies located in 48 low-z regular galaxy clusters with M200 ≥ 1014 M⊙ at z &lt; 0.1. We examine variations in the Kormendy relation (KR) according to their location in the projected phase space (PPS) of the clusters. We have used a combination of Bayesian statistical methods to identify possible differences between the fitted relations. Our results indicate that the overall KR is better fitted when we take into account the information about PPS regions. We also find that objects with time since infall ≥6.5 Gyr have a significant statistical difference of the KR coefficients relative to objects that are more recent in the cluster environment. We show that giant central ellipticals are responsible for tilting the KR towards smaller slopes. These galaxies present a late growth probably due to cumulative preprocessing during infall, plus cannibalism and accretion of smaller stripped objects near the centre of the clusters.
Distinct uptake and elimination profiles for trastuzumab, human IgG, and biocytin-TMR in experimental HER2+ brain metastases of breast cancer
Authors: Silvestri Vanesa L , Tran Andy D , Chung Monika , Chung Natalie , Gril Brunilde , Robinson Christina , Difilippantonio Simone , Wei Debbie , Kruhlak Michael J , Peer Cody J , Figg W Douglas , Khan Imran , Steeg Patricia S 
Published: February 2024

Abstract

Background
The aim of this study is an improved understanding of drug distribution in brain metastases. Rather than single point snapshots, we analyzed the time course and route of drug/probe elimination (clearance), focusing on the intramural periarterial drainage (IPAD) pathway.

Methods
Mice with JIMT1-BR HER2+ experimental brain metastases were injected with biocytin-TMR and either trastuzumab or human IgG. Drugs/probes circulated for 5 min to 48 h, followed by perfusion. Brain sections were stained for human IgG, vascular basement membrane proteins laminin or collagen IV, and periarterial α-SMA. A machine learning algorithm was developed to identify metastases, metastatic microenvironment, and uninvolved brain in confocally scanned brain sections. Drug/probe intensity over time and total imaged drug exposure (iAUC) were calculated for 27,249 lesions and co-immunofluorescence with IPAD-vascular matrix analyzed in 11,668 metastases.

Results
In metastases, peak trastuzumab levels were 5-fold higher than human IgG but 4-fold less than biocytin-TMR. The elimination phase constituted 85–93% of total iAUC for all drugs/probes tested. For trastuzumab, total iAUC during uptake was similar to the small molecule drug probe biocytin-TMR, but slower trastuzumab elimination resulted in a 1.7-fold higher total iAUC. During elimination trastuzumab and IgG were preferentially enriched in the α-SMA+ periarterial vascular matrix, consistent with the IPAD clearance route; biocytin-TMR showed heterogeneous elimination pathways.

Conclusions
Drug/probe elimination is an important component of drug development for brain metastases. We identified a prolonged elimination pathway for systemically administered antibodies through the periarterial vascular matrix that may contribute to the sustained presence and efficacy of large antibody therapeutics.
National liberation by other means: US visitor diplomacy in the Vietnam War
Authors: Asselin Pierre 
Published: February 2024

Abstract
This article considers Americans who travelled to North Vietnam at the height of the Vietnam War (1965–75). It demonstrates, on the basis of revelations in files from the Vietnamese national archives, that authorities in Hanoi exercised far more control over visits by US citizens and the impressions they created than the visitors themselves and those who have written about them had heretofore surmised. In visiting North Vietnam on Hanoi’s very specific terms, guests unwittingly — for the most part — became accomplices in its ‘diplomatic struggle’, a distinctive aspect of the Vietnamese communist anti-American strategy that was intended to diminish the importance of the military contest inside Vietnam by winning hearts and minds and demonizing Washington policy makers outside the country. By elucidating Hanoi’s rationale for and contributions in arranging the visits, the article decentres the history of the Vietnam War and validates the emergent consensus among international relations historians that traditionally marginalized ‘Third World’ state and non-state actors assumed meaningful roles in shaping the post-1945 international order. The Vietnam War, it turned out, changed the global discourse on the laws of war, human rights and humanitarianism in no small part because of the way Hanoi framed the conflict and reported its dreadful effects to foreign publics.
What is a high-quality research environment? Evidence from the UK’s research excellence framework
Authors: Inglis Matthew , Gadd Elizabeth , Stokoe Elizabeth 
Published: February 2024

Abstract
As part of the UK university sector’s performance-related research funding model, the ‘REF’ (Research Excellence Framework), each discipline-derived ‘Unit of Assessment’ must submit a statement to provide information about their environment, culture, and strategy for enabling research and impact. Our aim in this paper is to identify the topics on which these statements focus, and how topic variation predicts funding-relevant research environment quality profiles. Using latent Dirichlet allocation topic modelling, we analysed all 1888 disciplinary ‘unit-level’ environment statements from REF2021. Our model identified eight topics which collectively predicted a surprisingly large proportion—58.9%—of the variance in units’ environment scores, indicating that the way in which statements were written contributed substantially to the perceived quality of a unit’s research environment. Assessing research environments will increase in importance in the next REF exercise and the insights found through our analysis may support reflection and discussion about what it means to have a high-quality research environment.
Ambient dose equivalent rates of gamma radiation from natural radionuclides and 137Cs at grasslands and forests in the area of the Belarusian NPP in the pre-commissioning period (2019)
Authors: Ramzaev Valery , Bernhardsson Christian , Vodovatov Aleksandr , Chipiga Larisa , Nekrasov Vladislav , Dvornik Alexander 
Published: February 2024

Abstract
In situ gamma-spectrometric measurements were performed at grasslands (45 plots) and forests (6 plots) in the vicinity of the Belarusian nuclear power plant in September–October 2019. The aim of the study was to evaluate the baseline level of ambient dose equivalent rates of gamma radiation from natural radionuclides and 137Cs in the period preceding the commissioning of the NPP. The study revealed more than a 2-fold variability in values of the total ambient dose equivalent rate: from 29 to 72 nSv/h. This spread can be explained by variability in the content of natural radionuclides in the environment and, accordingly, ambient dose equivalent rate. At forest sites, compared to grassland sites, the values of ambient dose equivalent rates of gamma radiation from natural radionuclides were statistically significantly lower. The contribution of gamma radiation from 137Cs to the total ambient dose equivalent rate was insignificant and averaged 3% for grasslands and 6% for forests.
Anti-Asian Hate’s Impact on Asian American Social Workers: Implications for Professional Training and Education
Authors: Bersamira Clifford S , Lau Sophia B , Lee Yeonjung Jane , Yamauchi Jaron 
Published: February 2024

Abstract
This article explores the impact of recent incidents of anti-Asian hate and violence against Asian American social workers, clients, and communities. Asian Americans represent a small but growing proportion of the U.S. population. Yet, Asians are underrepresented in the social work profession—approximately 3.6 percent of the social work workforce and 2.1 percent of licensed social workers are Asian, and data on underrepresented racial and ethnic groups in the workforce continue to omit details on Asian people. Recent social and political framing of the COVID-19 pandemic as attributable to Asian people has fueled racist rhetoric and incidents of hate and bias crimes against Asian people. Through exploratory research to understand the experiences of Asian American social workers in the proliferation of anti-Asian hate, authors identified that more should be done to support and meet the needs of Asian American social workers, clients, and communities by improving social work education and training, by addressing the social work workforce and agency practices, and by expanding upon advocacy and community building.
Hexaconazole exposure may lead to Parkinson via disrupting glucocerebrosidase and parkin: molecular interaction, dynamics, MMPBSA and DFT based in-silico predictive toxicology
Authors: Alkholifi Faisal K , Abdi Sayed Aliul Hasan , Qadri Marwa , Sayed Shabihul Fatma , Khardali Amani , Nagarajan Sumathi , Abdulrahman Alhamyani , Aldabaan Nayef , Alghazwani Yahia 
Published: February 2024

Abstract
Hexaconazole is a known fungicide for agricultural purposes. It has bioaccumulation ability which makes it important for its toxicological characterization. There are various neurological impacts of pollutants on human health. Therefore, in this study, we have done predictive analyses of the interaction mechanism of hexaconazole by molecular interaction analysis, molecular dynamics simulation, and Poisson-Boltzmann surface area (MM-PBSA) to assess hexaconazole’s potency to disrupt the homeostasis of glucocerebrosidase (−7.9 kcal/mol) and parkin (−5.67 kcal/mol) proteins which have significant roles in the manifestation of Parkinson disease. The findings reveal that hexaconazole has the potency to form stable interactions with glucocerebrosidase and parkin. This research provides a molecular and atomic-level understanding of how hexaconazole exposure may disrupt the homeostasis of glucocerebrosidase and parkin. The root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration, and hydrogen bonding exhibited the potent molecular interactions of hexaconazole, which may lead to neurological manifestations such as Parkinson disease.
Rate of Unexpected Malignancy in Patients Undergoing Percutaneous Vertebroplasty after Implementing a New Scanning Protocol
Authors: Wickstrøm Line A. , Rafaelsen Søren R. , Andersen Mikkel Ø. , Andresen Andreas D. K. , Elmose Signe F. , Carreon Leah 
Published: February 2024

Study Design.
Retrospective quality improvement study.

Objective.
To investigate if the rate of unsuspected malignancy in biopsies in patients with VCF who underwent percutaneous vertebroplasty (PVP) at the same orthopedic department has changed after the implementation of a new MRI scanning protocol.

Summary of Background Data.
Discrimination between benign and malign vertebral compression fracture (VCF) can be difficult. However, early diagnosis of malignant VCF is crucial to further treatment and prognosis. An earlier study at an orthopedic department reported a rate of unsuspected malignancy of 4.9% in patients with VCF who underwent PVP when biopsies were obtained during the procedure. The MRI scanning protocol was changed in this period.

Methods.
Retrospective on 427 patients with vertebral compression fracture undergoing PVP from April 28, 2017 to April 28, 2022, identifying operated patients from the Danish national DaneSpine registry. Subsequently, individual clinical information was collected in journal records.

Results.
The rate of unsuspected malignancy was 0.9% (4/427), and the overestimation of malignant VCF was 50% (16/32).

Conclusion.
During the last 5 years, the rate of unsuspected malignancy in patients with VCF undergoing PVP has improved considerably from 4.9% to 0.9%. Furthermore, MRI is over-diagnosing malignancies. Thus, the new scanning procedure is effective in differentiating between benign and malign VCFs.

Level of Evidence.
3.
Stereotactic ablative radiation therapy in metastatic prostate cancer
Authors: Bazyar Soha , Mannuel Heather , Tran Phuoc T. 
Published: February 2024

Purpose of review
The evolving role of stereotactic ablative radiation therapy (SABR) as metastasis-directed therapy (MDT) for oligometastatic prostate cancer (omPCa) will be discussed.

Recent findings
Oligometastatic disease (OMD) is an intermediate state between localized and wide-spread malignant disease. OMD has recently been spotlighted given the increasing demonstration of clinical benefit from local therapies despite presence of metastatic disease and allure of the curative potential of MDT in select cases. Among the different forms of MDT, SABR has rapidly become a widely adopted treatment modality. Significant efforts in this space have focused on omPCa, owing to its relatively indolent biology, presence of a sensitive and specific serum biomarker and recent advances in molecular imaging. While most studies have evaluated the role of SABR MDT in hormone sensitive omPCa, new emerging clinical data also suggests benefits of SABR MDT for even castration-resistant disease.

Summary
Treating omPCa with SABR MDT appears to generate an efficacy signal with minimal morbidity across both hormone-sensitive and castration-resistant disease. However, additional definitive omPCa trial data are needed. Future research efforts should investigate biomarkers for this heterogeneous disease space and the role of SABR MDT in combination with systemic agents to improve upon standard of care treatments.
Comparison of Two Measurement Paradigms to Determine Electrically Evoked Cochlear Nerve Responses and Their Correlation to Cochlear Nerve Cross-section in Infants and Young Children With Cochlear Implant
Authors: Schrank Leonhard , Nachtigäller Pascal , Müller Joachim , Hempel John-Martin , Canis Martin , Spiegel Jennifer L. , Rader Tobias 
Published: February 2024

Introduction
Electrically evoked compound action potentials (ECAPs) are used for intra-/postoperative monitoring with intracochlear stimulation of cochlear implants. ECAPs are recorded in MED-EL (Innsbruck, Austria) implants using auditory response telemetry (ART), which has been further developed with automatic threshold determination as AutoART. The success of an ECAP measurement also depends on the number of available spiral ganglion cells and the bipolar neurons of the cochlear nerve (CN). It is assumed that a higher population of spiral ganglion cell implies a larger CN cross-sectional area (CSA), which consequently affects ECAP measurements.

Methods
Intraoperative ECAP measurements from 19 implanted ears of children aged 8 to 18 months were retrospectively evaluated. A comparison and correlation of ART/AutoART ECAP thresholds/slopes at electrodes E2 (apical), E6 (medial), E10 (basal), and averaged E1 to E12 with CN CSA on magnetic resonance imaging was performed.

Results
A Pearson correlation of the ART/AutoART ECAP thresholds/slopes for E2/E6/E10 and the averaged electrodes E1 to E12 showed a significant correlation. The CN CSA did not correlate significantly with the averaged ART/AutoART ECAP thresholds/slopes across all 12 electrodes.

Summary
AutoART provides reliable measurements and is therefore a suitable alternative to ART. No significant influence of CN CSA on ECAP thresholds/slopes was observed. A predictive evaluation of the success of ECAP measurements based on CN CSA for a clinical setting cannot be made according to the present data.
Asymmetry in Cortical Thickness of the Heschl’s Gyrus in Unilateral Ear Canal Atresia
Authors: Siegbahn Malin , Jörgens Daniel , Asp Filip , Hultcrantz Malou , Moreno Rodrigo , Engmér Berglin Cecilia 
Published: February 2024

Hypothesis
Unilateral congenital conductive hearing impairment in ear canal atresia leads to atrophy of the gray matter of the contralateral primary auditory cortex or changes in asymmetry pattern if left untreated in childhood.

Background
Unilateral ear canal atresia with associated severe conductive hearing loss results in deteriorated sound localization and difficulties in understanding of speech in a noisy environment. Cortical atrophy in the Heschl’s gyrus has been reported in acquired sensorineural hearing loss but has not been studied in unilateral conductive hearing loss.

Methods
We obtained T1w and T2w FLAIR MRI data from 17 subjects with unilateral congenital ear canal atresia and 17 matched controls. Gray matter volume and thickness were measured in the Heschl's gyrus using Freesurfer.

Results
In unilateral congenital ear canal atresia, Heschl's gyrus exhibited cortical thickness asymmetry (right thicker than left, corrected p = 0.0012, mean difference 0.25 mm), while controls had symmetric findings. Gray matter volume and total thickness did not differ from controls with normal hearing.

Conclusion
We observed cortical thickness asymmetry in congenital unilateral ear canal atresia but no evidence of contralateral cortex atrophy. Further research is needed to understand the implications of this asymmetry on central auditory processing deficits.
Asymptomatic uterine perforation and IUD migration to the broad ligament: A case report
Authors: Jia Guifeng , Liu Xiaojing , He Yanling , Du Peng , Sun Zhiwei , Chai Wei 
Published: February 2024

Rationale:
Uterine perforation is a serious complication of intrauterine contraceptive device (IUD) placement. However, as complete uterine perforation and extrauterine migration may remain asymptomatic, thorough localization of the IUD is important prior to reinsertion.

Patient concerns:
A 33-year-old patient who has had 4 IUD insertions, wherein the location of the first IUD (inserted 14 years ago) was not identified prior to reinsertion and replacement of the subsequent three. She presented to hospital with a 6-month history of abdominal pain. Pelvic ultrasonography (US), radiography, hysteroscopy and laparoscopy examinations confirmed that a retained migrated IUD in the right broad ligament.

Diagnosis:
Uterine perforation, IUD migration to the broad ligament.

Interventions:
The patient underwent hysteroscopy and laparoscopy.

Outcomes:
Both IUDs were successfully removed without any complications.