bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possibilities of Using the National Electronic Data Syetstem in Assessing the Control of Arterial Hypertension at The Primary Health Care Level in the Kyrgyz Republic Using the Example of a Single Family Medicine Center
Authors: Polupanov A. G. , Arykova A. T. , Tolebaeva A. A. , Borubaev M. Ch. , Altymysheva A. T. , Dzhishambaev E. D. , Dzhamagulova A. S. , Abilova S. S. , Sooronbaev T. M. 
Published: February 2024

Aim. To determine the capabilities of the National Electronic System for collecting quantitative data necessary to assess the quality of management and effectiveness of arterial hypertension (AH) control at the primary health care (PHC) level and to develop indicators and possibilities of their use for a standardized report on the quality of AH management and control at the PHC level in the Kyrgyz Republic.Material and methods. Data from electronic outpatient records were processed for all registered patients of a pilot family medicine center (FMC) that was selected randomly. The registered patient group consisted of 91,226 people older than 18 years, including 37,740 men and 53,486 women. The data obtained during contact with a patient was entered by the family doctor into the electronic outpatient record and automatically forwarded to the center that collected and aggregated the data. To monitor AH control, 11 indicators were developed and evaluated. The indicators were divided into 3 groups: indicators for identifying AH, indicators for the quality of AH patient management, and indicators for the effectiveness of AH control.Results. In total, 26,206 patients (7,933 men and 18,273 women) visited the FMC during a year, and blood pressure (BP) was measured in 71.4% of them. In 2022, 5,072 patients (5.6% of the registered group) visited the FMC for AH, including 1,539 men and 3,533 women (4.1 and 6.6% of the registered patient group, respectively; p<0.001). The proportion of patients with AH who, according to the clinical protocol, had their BP measured 2 times a year or more, was 81.4% and was slightly higher for women than for men (82.3% and 79.1%, respectively; p<0.01). 38.7% of AH patients received antihypertensive drugs. Lipid-lowering therapy was prescribed to 23.5% of AH patients. The proportion of AH patients taking acetylsalicylic acid was higher, 36.3% for the whole group, including 34.1% for men and 37.2% for women (p<0.05). The efficacy of AH treatment was 62.8%.Conclusion. Any monitoring system has limitations for the amount of useful data that can be obtained ensuring their proper quality. Taking this into account, two major indicators are suggested to use for evaluating the effectiveness of AH control at the PHC level: 1) the number of AH patients who have achieved the BP goal; 2) the number of AH patients who visited a medical institution (health care facility) during a calendar year relative to the number of registered patients (AH detectability).
My “Philosophical Generation”
Authors: Mikhailovsky A.V. 
Published: February 2024

The article examines the phenomenon of generation, self-understanding / self-recognition in a generation from the standpoint of hermeneutical philosophy. The first part is a reproduction of the author&#x27;s 1999 essay. It notes that 1) in the testimonies of individual representatives of the generation, mediation of the individual and the universal is carried out; 2) the identity of the generation is understood through a relationship with another; 3) for self-recognition in the generation, the “pre-reflexive” level is important, which precedes the division into intellectual and sensual. The second part contains a description of events, meetings with people, reading experiences and experiences of a representative of a generation whose intellectual formation took place mainly in the last decade of the 20th century.
Implikasi Program Adiwiyata terhadap Karakter Peduli Lingkungan di Sekolah Dasar
Authors: Sari Kumila , Sugiyono  , Suryatin Suryatin 
Published: February 2024

Penelitian ini bertujuan untuk mendeskripsikan pelaksanaan program adiwiyata dan implikasi pelaksanaan program adiwiyata terhadap karakter peduli lingkungan di Sekolah Dasar Negeri 2 Purwoasri. Jenis penelitian ini adalah deskriptif kualitatif. Subjek penelitian ini adalah kelas V. Objek penelitian adalah pelaksanaan program adiwiyata dan karakter peduli lingkungan. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dokumentasi dan angket. Teknik pemeriksaan keabsahan data menggunakan triangulasi sumber dan teknik. Teknik analisis data yang digunakan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa: (1) pelaksanaan program adiwiyata di Sekolah Dasar Negeri 2 Purwoasri memiliki kategori sangat baik dengan skor sebesar 4,14 dan terlaksana sesuai standar program adiwiyata dari pemerintah, (2) implikasi program adiwiyata terhadap karakter peduli lingkungan siswa di Sekolah Dasar Negeri 2 Purwoasri pada kategori sangat baik dengan persentase sebesar 53% dan kategori baik dengan persentase 47%.
Interplay Between Element-Specific Distortions and Electrocatalytic Oxygen Evolution for Cobalt-Iron Hydroxides
Authors: Smith Rodney , Alsaç Elif , Boke Marlyn , Bissonnette Justine 
Published: February 2024

Abstract
A microscopic understanding of how Fe-doping of Co(OH)2 improves electrocatalytic oxygen evolution remains elusive. We study two Co1-xFex(OH)2 series that differ in fabrication protocol and find composition alone poorly correlates to catalyst performance. Structural descriptors extracted using X-ray diffraction, X-ray absorption spectroscopy, and Raman spectroscopy reveal element-specific distortions in Co1-xFex(OH)2. These structural descriptors are composition-dependent within individual sample series but inconsistent across fabrication protocols, revealing fabrication-dependence in catalyst microstructure. Correlations between structural parameters from different techniques show that Fe-O resists bond length changes, forcing distortion of Co environments. We find the difference in O-M-O bond angles between Co and Fe sites to correlate with electrocatalytic behavior across both sample series, which we attribute to asymmetric distortion of potential energy surfaces for the Co(III) to Co(IV) oxidation. A Tafel slope consistent with a rate-limiting step without electron transfer emerges as the O-Co-O angle decreases, implying a distortion-induced transition in rate-limiting step. The fabrication dependence of electronic and bonding structure in the catalysts should be considered in theoretical and high-throughput analyses of electrocatalyst materials.
Dairy cattle welfare: knowledge, attitudes and practices of stockpeople from Midlands Province- Zimbabwe’s large-scale dairy farms”
Authors: Matore Zivanayi , Woods Pamela SA , Mutibvu Tonderai 
Published: February 2024

Abstract

Welfare of dairy animals and consequently their health and productivity is influenced by a number of factors such as the quality and quantity of supplement, health care given to animals, and stockpeoples; knowledge, attitudes and practices (KAP) on animal welfare. Studies have been conducted to evaluate the influence of most of the above factors on welfare of dairy animals, but very few studies focused on the influence of stockpeoples’ KAP on dairy welfare. A cross sectional study involving 93 stockpeople from the 31 large-scale dairy farms in the Midlands Province, Zimbabwe was conducted to determine their KAP on animal welfare. Results revealed that 67% of the stockpeople could not define animal welfare and this was significantly associated with the stockperson’s level of education (χ2 = 12.54, df = 3, p = 0.006). Only 14% of the stockpeople interviewed always talked to dairy cows when handling them and this was significantly associated with gender of the stockperson (χ2 = 10.7, df = 2, p < 0.001). About 20% of the stockpeople responded positively to touching the dairy animals when handling them and this was associated significantly with the stockperson’s gender (p = 0.005). On responses to whipping of animals when driving them, about 90% of the stockpeople said they never whip animals when handling or driving them. It is recommended that further studies be done to find better and more effective ways of teaching animal welfare concepts and practices.
WITHDRAWN: Spirulina C-phycocyanin: extraction, purification, stabilization, and inhibitory potential of key enzymes rRelated to pancreas inflammation, carbohydrate digestion, and glucose metabolism
Authors: Saїdi Saber Abdelkader , Al-Shaikh Turki M. , Hamden Khaled 
Published: February 2024

Abstract
The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
A comparative study of retroperitoneal laparoscopic adrenalectomy via intra and extra perinephric fat approaches
Authors: Tan Qi , Lin Fan , He Yunfeng , Luo Shengjun 
Published: February 2024

Abstract
Objective
To investigate the safety and effectiveness of retroperitoneal adrenalectomy via extra and intra perinephric fat approaches to provide experience and basis for resection of adrenal tumors through the retroperitoneal cavity.
Methods
The clinical data of 284 patients undergoing retroperitoneal adrenalectomy in our hospital from December 2017 to March 2023 were collected. The basic characteristics of the two groups of patients and the changes in perioperative indicators were retrospectively analyzed.
Results
A total of 117 patients with intra perinephric fat approach (IPFA) were included,and 167 patients with extra perinephric fat approach (EPFA) were included. Estimated blood loss,operation time and hospitalization expenses were comparable between the two groups.The estimated blood loss in the IPFA group (123.59 ± 50.76ml) was higher than that in the EPFA group (99.10 ± 99.51ml) (p = 0.015),and the operative time in the IPFA group(105.25 ± 42.25min) was longer than that in the EPFA group(81.75 ± 30.45min) (p = 0.000).The hospitalization expenses of IPFA patients(36306.39 ± 7544.25RMB)was more expensive compared with patients receiving EPFA(32122.77 ± 7284.00RMB)(p = 0.000).There were no significant differences between the two groups in terms of tumor size,blood transfusion times and postoperative hospitalization time.
Conclusion
Retroperitoneal laparoscopic adrenalectomy is a safe and effective procedure that can be performed via extra and intra perinephric fat approaches. IPFA is more than EPFA in terms of estimated blood loss, and the operation time of EPFA is shorter than IPFA. The choice of surgical approach may depend primarily on the experience of the surgeon, the characteristics of adrenal tumor, and the nature of perirenal adipose tissue.
Combined oral contraceptive use and adiposity in women with polycystic ovary syndrome. A meta-analysis of randomized clinical trials
Authors: de Medeiros Sebastião Freitas , Junior José Maria Soares , de Medeiros Matheus Antônio Souto , Yamamoto Ana Karine Lin Winck , de Medeiros Cindy Lin Winck , Carvalho Anna Bethany da Silva , Yamamoto Márcia Marly Winck , Baracat Edmund Chada 
Published: February 2024

Abstract

Background.
Combined oral contraceptives (COCs) are of first line treatment of women with polycystic ovary syndrome (PCOS) who do not intend to become pregnant. PCOS is a heterogeneous condition with subphenotypes with different risks for future development of cardiovascular disease. The combination of COC and PCOS may or may not amplify the risks of cardiovascular events.
Objective.
To investigate whether surrogates for adiposity may be influenced by the use of COCs with different formulations in women with PCOS.
Method.
A literature search was conduct in Google Scholar and Pubmed databases. Hand search of randomized clinical trials in the references of obtained manuscripts was also performed. The search identified 3820 articles and 13 randomized clinical trials in which was possible to compare the results obtained before and after the use of COCs. Random-effects model was used to estimate the standardized mean differences (SMD) and standard erros (SE). Risk of bias was examined using the Rob2 tool.
Result.
Thirteen heterogeneous RCTs reported no difference on waist circumference with the use of different COC formulations (p = 0.714). On the contray, body fat mass increased with the use of pill (p = 0.013). Anthropometric-metabolic biomarkers waist triglyceride index and visceral adiposity index did not change but the lipid accumulation product tended to be higher after use of COCs.
Conclusion.
Combined oral contraceptives with different formulations might increase fat mass accumulation in women with PCOS. Lipids may also be accumulated in the PCOS users.
Prosthetic Maintenance Assessment for Two Implant-Retained Overdentures Reinforced with PEKK versus Co-Cr Framework: A Randomized Controlled Clinical Trial
Authors: Refai Omnia M. , Salama Heba A. 
Published: February 2024

Abstract
Background: The primary challenge associated with implant-retained overdentures lies in the occurrence of denture fractures around the attachment region. Hence, it is recommended to enhance flexural strength through reinforcement frameworks. This study aimed to assess and compare the prosthetic maintenance of mandibular implant-retained overdentures reinforced with Co-Cr and PEKK frameworks.
Material and Methods: Twenty-four participants with completely edentulous maxillary and mandibular ridges were selected, and two implants were placed at the mandibular canine areas using a two-stage surgical technique with the help of a radiographic and surgical stent. After a three-month osseointegration period, ball attachments were installed. Participants were randomly assigned to two groups based on the prostheses received: Group Ireceived a mandibular implant-retained overdenture reinforced with a Co-Cr framework, while Group II received a mandibular implant-retained overdenture reinforced with a PEKK framework. Both groups were also rehabilitated with a maxillary removable complete denture. Prosthetic maintenance evaluations for mandibular implant-retained overdentures in both groups were conducted twelve months post-denture insertion. Categorical data were analyzed using Fisher's exact test, and results were presented as frequency and percentage values.
Results: Group II exhibited a significantly higher percentage of cases with screw looseness, denture relining, and tooth separation compared to Group I. Although Group II cases showed a non-significant increase in the percentage of insert wear and retention loss.
Conclusion: Within the limitations of this study, the findings suggest that Co-Cr, in contrast to PEKK frameworks, offers a more reliable reinforcement of the implant-retained overdentures.
Trial registration: The research was registered retrospectively and published on https://clinicaltrials.gov/ with the NCT number (NCT06219811) and registration date 23/01/2024.
Effect of salivary cotinine levels in beedi smokers and tobacco chewers on periodontal conditions
Authors: Muralidaran Gayathri , DV Nagarathna , Thomas Nithya Annie , Paul Arpita , Babu Ramesh , Thimmaiah Charisma 
Published: February 2024

Abstract
Objective
Tobacco consumption is one of the risk factors for periodontal disorders. This study aims to assess the periodontal health among beedi smokers and tobacco chewers and its correlation to salivary cotinine levels.
Methodology:
60 tobacco-consuming patients between 25–50 years were included in the study. 30 patients were beedi smokers and 30 were smokeless tobacco users. The gingival health was assessed using Gingival Index (GI), Plaque Index (PI) and Sulcular Bleeding Index (SBI). Periodontal health was determined by clinical attachment loss (CAL) and probing pocket depth (PPD). Unstimulated saliva was collected and subjected to Enzyme linked immunoassay (ELISA). The correlation between the number of times smoked or chewed per day and the number of years to clinical and biochemical parameters was done.
Results
The number of beedi smoked daily and number of years smoked was higher than tobacco chewed which was statistically significant (p < 0.001). GI and PI were more significant in beedi smokers than tobacco chewers (p < 0.001). SBI was not significant between both groups (p = 0.859). PPD was more significant in beedi smokers (p = 0.035) but CAL was not significant (p = 0.39). Salivary cotinine is not significant (p = 0.41) and is increased in tobacco chewers (mean = 99.484) than beedi smokers (mean = 94.760).
Conclusion
Beedi smoking has more adverse effects on periodontium than tobacco chewing. Yet tobacco chewing also has its unfavorable effects.
Comparison of arterial spin-labeled perfusion magnetic resonance imaging between the Attention deficit-hyperactivity disorder and the control group, ages of 6-12.
Authors: Lim You Bin , Song Huijin , Lee Hyunjoo , Kwon Seo Young , Chun Jeeyoung , Kim Sujin , Lim Seungbee , Tosun Ceren , Yoon Kyung Seu , Sohn Chul-Ho , Kim Bung-Nyun 
Published: February 2024

Abstract
This study utilized Arterial Spin Labeling-Magnetic Resonance Imaging (ASL-MRI) to explore the developmental trajectory of brain activity associated with attention deficit hyperactivity disorder (ADHD). Pulsed arterial spin labeling (PASL) data were acquired from 109 children with ADHD and 58 children in a control group, all aged 6–12 years old. Participants were categorized into the age groups of 6–7, 8–9, and 10–12, after which comparisons were performed between each age group. In total, the ADHD group exhibited significantly lower activity in the left superior temporal gyrus and right middle frontal gyrus regions than the control group. Further analysis revealed: 1) The comparison between the ADHD group (N = 51) aged 6–7 and the age-matched control group (N = 22) showed no statistically significant difference between. 2) However, compared with the control group aged 8–9 (N = 19), the ADHD group of same age (N = 33) showed significantly lower ASL activities in the left postcentral gyrus and left middle frontal gyrus regions. 3) Further, the ADHD group aged 10–12 (N = 25) demonstrated significantly lower activities in the left superior occipital region than the age-matched control group (N = 16). These age-specific differences suggest variations in ADHD-related domains during brain development post age 6–7. Understanding these patterns may enhance ADHD treatment strategies.
Comparing ChatGPT Responses with AHA Guidelines for Assessing Unruptured Intracranial Aneurysms: Establishment of a Simple Rating System
Authors: Chang Yu , Lee Po-Hsuan , Huang Chi-Chen , Wong Chia-En , Perng Pang-Shuo , Lee Jung-Shun , Wang Liang-Chao , Huang Chih-Yuan 
Published: February 2024

Abstract
Introduction
Efficient diagnosis and intervention for unruptured intracranial aneurysms (UIAs) are crucial for favorable outcomes. Our study aimed to evaluate the accuracy and alignment of Chat Generative Pre-trained Transformer (ChatGPT) with established medical standards by systematically evaluating its responses using the American Heart Association (AHA) guidelines for the management of UIAs as a reference. This initiative bridges advanced artificial intelligence (AI) technology and medical practice norms, and contributes to the discussion on the role of AI in the dissemination of medical information.
Methods
In our collaborative study, we systematically assessed ChatGPT 3.5's responses by posing clinical questions aligned with AHA guidelines and evaluating them on a 1 to 5 scale for agreement and comprehensiveness. This method allowed us to objectively gauge ChatGPT's alignment with AHA medical guidelines.
Results
We introduced a set of ten clinical questions related to UIAs. Within this set, ChatGPT's responses achieved a 5-point rating for four questions. A further four questions were rated 3 points, and the remaining two questions received a score of 2.
Conclusions
By establishing a scoring system, we assessed the accuracy of ChatGPT responses to questions related to UIAs. It provides excellent results for screening, risk factors, and as a diagnostic tool. However, there is room for improvement in terms of the rupture risk and management.
Detection and Genetic Analysis of Bovine Rhinitis B Virus in Japan
Authors: ishida hiroho , Nakamura Mikari , Murakami Hironobu , Kazama Kei , Oba Mami , Takemae Hitoshi , Mizutani Tetsuya , Ouchi Yoshinao , Kawakami Junko , Tsuzuku Satoko , Nagai Makoto 
Published: February 2024

Abstract

Bovine rhinitis B virus (BRBV) (genus: Aphthovirus, family: Picornaviridae), is a significant etiological agent of the bovine respiratory disease complex. Despite global reports on BRBV, genomic data for Japanese strains are unregistered. Herein, we aimed to analyze the genetic characteristics of BRBV in Japan. In nasal swabs from 66 cattle, BRBV was detected in 7/10 and 4/56 symptomatic and asymptomatic cattle, respectively. Metagenomic sequencing and Sanger sequencing identified two Japanese BRBV strains, IBA/2211/2 and LAV/238002, which shared significant genetic similarity with known BRBV strains and exhibited unique mutations and recombination events, indicating dynamic evolution, influenced by regional environmental and biological factors. Notably, the leader gene of LAV/238002 was positioned in a distinct evolutionary lineage, significantly diverging from the other BRBV strains. Phylogenetic analysis based on the amino acid sequence of leader protein showed that both Japanese strains were in a distinctly different clade from other BRBV strains, indicating significant genetic diversity. These findings provide insights into the genetic makeup of the Japanese BRBV strains, enriching our understanding of their genetic diversity and evolutionary mechanisms.
Isolation and genetic characterization of novel bovine parechovirus from Japanese black cattle
Authors: Oba Mami , Shimotori Mayo , Teshima Natsuko , Yamaguchi Lisa , Takemae Hitoshi , Sakaguchi Shoichi , Ishida Hiroho , Murakami Hironobu , Mizutani Tetsuya , Nagai Makoto 
Published: February 2024

Abstract

Novel bovine parechoviruses (Bo_ParVs) were isolated from the feces of Japanese black cattle. Phylogenetic analysis revealed that the novel Bo_ParVs formed an independent cluster, exhibiting 72.2%-75.6% nucleotide and 85.7%-87.0% amino acid sequence identities with previous Bo_ParVs, suggesting that these strains represent a new genotype. Bo_ParVs, including the novel Bo_ParVs, shared sequence similarity with each other in the 3' untranslated region (3'UTR) and exhibited low sequence identities (< 38.9%) to other parechoviruses. However, secondary structure prediction of the 3'UTR revealed that Bo_ParVs shared conserved motifs with the Parechovirus-B and E viruses, suggesting that they have evolved in the same manner.