bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the total outflow of reservoirs using Wavelet-developed approaches: a case study of the Mahabad Dam reservoir, Iran
Authors: Emadi Alireza , Zamanzad-Ghavidel Sarvin , Boroomandnia Arezoo , Fazeli Sina , Sobhani Reza 
Published: November 2023

Abstract

Lack of water reserves in artificial reservoirs poses serious challenges in meeting various human requirements, especially during periods of water scarcity. In the current research, the Total Outflow (TO) of the Mahabad Dam reservoir has been estimated under six scenarios including the Monthly Cumulative Rainfall (MCR), Snow Water Equivalent (SWE), Stream Flow (SF), Mean Temperature (T), Pan Evaporation (Ep), Sediment Flushing Gate Outlet (SFGO), Penstock Outflow (PO), Evaporation Losses (EL), Cumulative Non-Scheduled Discharge (CNSD), Live Storage Volume (LSV), Water Surface Area (WSA), Monthly Water Level (MWL), Total Allocated Water (TAW), and Generated Power (GP) variables for the 2001–2021 period. Estimation of TO is accomplished via individual and wavelet-developed (W-developed) data-mining approaches, including Artificial Neural Networks (ANNs), wavelet-ANNs (WANNs), adaptive neuro-fuzzy inference system (ANFIS), wavelet-ANFIS (WANFIS), Gene Expression Programming (GEP), and wavelet-GEP (WGEP). The obtained values of RMSE for WGEP1–WGEP6 models account for 5.917, 2.319, 4.289, 8.329, 10.713, and 9.789 million cubic meters (MCM), respectively, based on the following scenarios: reservoir inlet elements, reservoir outlet elements, consumption, storage characteristic, climate, and energy. This research revealed that combining the wavelet theory (WT) with individual models can be a powerful method to improve the modeling performance in the TO estimation.
Design and spatial pattern optimization for a sponge city using factor analysis and geographical statistics to restore urban resilience: A case study in a coastal area of China
Authors: Yuan Yingwei , Zhang Qian , Chen Sheming , Chen Feiwu , Zhang Mucheng 
Published: November 2023

Abstract

The sponge city is a new concept of stormwater management for ecological city construction, which aims to restore water-cycle processes and reduce runoff. Cities in coastal districts are suffering from serious instability due to high population density, urbanization, and land-use changes. However, previous research contains few evaluations of balancing urban ecological indicators of sponge city performance, including geographical, environmental, economic, and social factors, and their effect on resilience at a macro level to develop low-impact development schemes. In this study, we developed an integrated framework using factor analysis, geographical statistics, multi-objective analysis, and remote sensing methods to extract the factors influencing sponge city resilience and to establish spatial pattern schemes. The results indicated that the urbanization degree and plant adaptability had the greatest impact on sponge city performance, with weights of 45 and 27%, respectively. Sponge city spatial pattern schemes performed the best in the combination scenario of 14.8–46.8% green roofs (by area ratio) supported by grooves and rain barrels +10% herbaceous basins divided into units by ecological tree pools +10% permeable pavements and sidewalks. This scenario balanced facilities and cost to optimize the spatial pattern, which improved sponge city adaptability and urban ecological conditions.
Detection of SARS-CoV-2 RNA in wastewater from dormitory buildings in a university campus: comparison with individual testing results
Authors: Williams Brandi B. , Newborn Aaron , Karamat Ayesha , Zamcho Fanella , Salerno Jennifer L. , Gillevet Patrick M. , Farris David , Wintermeyer Stephen F. , Van Aken Benoit 
Published: November 2023

Abstract

Wastewater-based epidemiology (WBE) for monitoring COVID-19 has been largely used to detect the spread of the disease at the community level. From February to December 2022, we collected 24-h composite sewage samples from dormitory buildings in George Mason University (Fairfax, Virginia, USA) housing approximately 5,200 resident students. SARS-CoV-2 RNA extraction was achieved using an automated system based on magnetic nanoparticles. Analysis of SARS-CoV-2 RNA was performed using reverse transcription quantitative PCR based on the Centers for Disease Control and Prevention (CDC) N1 and N2 assays. From the 362 samples collected, 86% showed positive detection of SARS-CoV-2 RNA. Wastewater monitoring was able to detect SARS-CoV-2 RNA in 96% of the samples from buildings housing students with COVID-19. Over the period of study, we observed significant correlations between the SARS-CoV-2 concentration (copy number mL−1) in wastewater and the number of positive cases on campus based on individual saliva testing. Although several reports have been published on the wastewater monitoring of COVID-19 in university campuses, our study is one of the very few that provides results that were obtained during the last phase of the pandemic (roughly the year 2022), when the large majority of students were vaccinated and back on campus.
miR-628-5p is a Potential Novel Prognosis Biomarker, Associated with Immune
Infiltration in Bladder Urothelial Carcinoma
Authors: Huang Hong , Xu Qingchun , Zhang Yonghai , Zhou Yizhou , Ma Kaiqun , Luo Yingxun 
Published: November 2023

Background::
microRNA-628-5p (miR-628-5p) has a significant impact on certain types of cancer.
The precise function of miR-628-5p in the context of bladder urothelial carcinoma (BLCA) remains ambiguous.

Objective::
We aimed to investigate the role of miR-628-5p in BLCA.

Methods::
The samples were collected from The Cancer Genome Atlas (TCGA). Statistics were employed to
evaluate the correlation and predictive significance of miR-628-5p. We analyzed the target genes and regulatory
network of miR-628-5p and the correlation between miR-628-5p and immune infiltration. The expression
of miR-628-5p in BLCA cells was confirmed by quantitative reverse-transcription PCR (qRT-PCR).

Results::
miR-628-5p exhibited differential expression across various types of cancer. There was a significant
association between high expression of miR-628-5p and primary therapy outcome (p < 0.05). High expression
of miR-628-5p was observed to be associated with poorer overall survival (HR: 1.42; 95% CI: 1.06-1.90; p =
0.02), progress free survival (HR: 1.57; 95% CI: 1.17-2.11; p = 0.003), and disease specific survival (HR:
1.83; 95% CI: 1.28-2.62; p = 0.001) in BLCA. miR-628-5p was an independent prognostic factor in BLCA
and may be involved in the development of the disease through various pathways, including focal adhesion,
ECM-receptor interaction, PI3K-Akt signaling pathway, and MAPK signaling pathway, and among others.
miR-628-5p expression was significantly correlated with immune infiltration in BLCA patients. Compared to
normal bladder epithelial cells, BLCA cell lines exhibited a significant upregulation of miR-628-5p.

Conclusion::
It is possible that miR-628-5p could serve as a hopeful therapeutic target and prognostic biomarker
for individuals with BLCA.
Chemistry and Therapeutic Aspect of Triazole: Insight into the Structure-activity Relationship
Authors: Sharma Shikha , Mittal Nitin , Banik Bimal Krishna 
Published: November 2023

Abstract:
The triazole ring is a highly significant heterocycle that occurs naturally in many commodities and
is a common feature in pharmaceuticals. Recently, heterocyclic compounds and their derivatives have been
getting a lot of attention in medicinal chemistry because they have a lot of pharmacological and biological potential.
For example, a lot of drugs have nitrogen-containing heterocyclic moieties. The triazole ring is often
used as a bio-isostere of the oxadiazole nucleus. The oxygen atom in the oxadiazole nucleus is replaced by
nitrogen in the triazole analogue. This article explores the pharmacological properties of the triazole moiety,
including but not limited to antibacterial, analgesic, anticonvulsant, anthelmintic, anti-inflammatory, antitubercular,
antimalarial, antioxidant, antiviral, and other properties. Additionally, we discuss the diverse multi-
target pharmacological activities exhibited by triazole-based compounds. Based on a literature review, it is
evident that triazole-based chemicals hold significant potential for various applications.
Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like
Factor 9 (KLF9)
Authors: Siswanto Ferbian Milas , Handayani Maria Dara Novi , Firmasyah Rita Dewi , Oguro Ami , Imaoka Susumu 
Published: November 2023

Aims:
The aim of the present study is to gain insight into the biology of Parkinson’s disease (PD) and
cancer to drive translational advances enabling more effective prevention and/or potential treatments.

Background:
The expression of Cytochrome P450 2D6 (CYP2D6) is correlated with various diseases such as PD
and cancer; therefore, exploring its regulatory mechanism at transcriptional levels is of interest. NF-E2-related
factor 2 (Nrf2) has been known to be responsible for regulating phase II and phase III drug-metabolizing genes.

Objectives:
The objectives of this study are to investigate the transcriptional regulation of CYP2D6 by Nrf2 and to
analyze its role in PD and cancer.

Methods:
Nrf2 was transiently expressed in human hepatoma Hep3B cells, and the expression of CYP2D6 was
examined by RT-qPCR. The promoter activity of CYP2D6 and the DNA binding of Nrf2 were examined by luciferase
and ChIP assay, respectively. We then investigated the expression and correlation of Nrf2 and CYP2D6 in
the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets.

Results:
In the present study, we demonstrated that Nrf2 down-regulated CYP2D6 mRNA expression in hepatoma
Hep3B cells. Mechanistically, Nrf2 binds to the antioxidant responsive element (ARE) in the proximity of krüppel-
like factor 9 (KLF9)-binding site within the −550/+51 of CYP2D6 promoter. The inhibition and activation of
Nrf2 enhanced and suppressed KLF9 effects on CYP2D6 expression, respectively. The expression levels of Nrf2
and CYP2D6 were upregulated and downregulated in the PD patient GEO datasets compared to the healthy control
tissues, and Nrf2 was negatively correlated with CYP2D6. In liver cancer patients, decreased CYP2D6 levels
were apparent and associated with a lower probability of survival.

Conclusion:
Our work revealed the inhibitory role of Nrf2 in regulating CYP2D6 expression. Moreover, Nrf2-
dependent regulation of CYP2D6 can be used as a prognostic factor and therapeutic strategy in PD and liver cancer.
A Review of Cartilage Defect Treatments Using Chitosan Hydrogels in
Experimental Animal Models
Authors: Souza-Silva Lais Caroline , Cristina  Santi Martignago Cintia , Garcia Motta Homero , Bonifacio Mirian , Regina Avanzi Ingrid , Assis Lívia , Araki Ribeiro Daniel , Risso Parisi Julia , Claudia Rennó Ana 
Published: November 2023

Introduction:
Chitosan (CS) is a polycationic polysaccharide comprising glucosamine
and N-acetylglucosamine and constitutes a potential material for use in cartilage tissue engineering.
Moreover, CS hydrogels are able to promote the expression of cartilage matrix components
and reduce inflammatory and catabolic mediator production by chondrocytes. Although all the
positive outcomes, no review has analyzed the effects of CS hydrogels on cartilage repair in
animal models.

Methods:
This study aimed to review the literature to examine the effects of CS hydrogels on
cartilage repair in experimental animal models. The search was done by the descriptors of the
Medical Subject Headings (MeSH) defined below: “Chitosan,” “hydrogel,” “cartilage repair,”
and “in vivo.” A total of 420 articles were retrieved from the databases Pubmed, Scopus, Embase,
Lilacs, and Web of Science. After the eligibility analyses, this review reported 9 different
papers from the beginning of 2002 through the middle of 2022.

Results:
It was found that cartilage repair was improved with the treatment of CS hydrogel, especially
the one enriched with cells. In addition, CS hydrogel produced an upregulation of genes
and proteins that act in the cartilage repair process, improving the biomechanical properties of
gait.

Conclusion:
In conclusion, CS hydrogels were able to stimulate tissue ingrowth and accelerate
the process of cartilage repair in animal studies.
Hybrids of Benzimidazole-oxadiazole: A New Avenue for Synthesis,
Pharmacological Activity and Recent Patents for the Development of More
Effective Ligands
Authors: Bhasker Gunjan , Salahuddin  , Mazumder Avijit , Kumar Rajnish , Kumar Greesh , Ahsan Mohamed Jawed , Shahar Yar Mohammad , Khan Fahad , Kapoor Bhupinder 
Published: November 2023

Background:
Two significant families of compounds i.e. 1,3,4-oxadiazole and ben-zimidazole, have undergone extensive investigation into their pharmacological characteristics and possible therapeutic applications. Both classes have shown their potential in a variety of ap-plications, and because of their synergistic interactions, they may have an even better therapeutic impact when combined.

Objectives:
To produce a specific molecule with potent therapeutic properties, it is now common methods to combine at least two pharmacophores. This facilitates interaction with several targets, enhances biological functions, or eliminates adverse effects associated with them.

Conclusion:
The synthesis of benzimidazole-1,3,4-oxadiazole hybrid compounds has recently involved the use of several synthetic techniques, all of which are detailed in the literature along with the advantages and disadvantages. It has been noted that the structure-activity relationship relates their pharmacological actions to their molecular structure. In order to set the stage for future research, the study aims to provide researchers with an effective toolbox and an under-standing of benzimidazole and 1,3,4-oxadiazole hybrid compounds.
QSAR, Molecular Docking & ADMET Studies of Pyrrolo[2,3-d] Pyrimidine
Derivatives as CDK4 Inhibitors for the Treatment of Cancer
Authors: Patil Shital M. , Patil Varsha A. , Asgonkar Kalyani , Randive Vrushali , Mahadik Indrani 
Published: November 2023

Background::
Cancer is caused by dysregulation of the cell cycle, which results in abnormal proliferation and the inability of cells to differentiate or die. Cyclins
and cyclin-dependent kinases (CDK4) inhibitors are drugs that target a specific enzyme, CDK4 that controls cell cycle progression in cancer.

Aim & Objective::
The aim of this study is to obtain an optimized pharmacophore of pyrrolo[2,3-d] pyrimidine as a CDK4 inhibitor using QSAR studies. This aids in
determining the link between structure and activity in newly developed chemical entities (NCE’s). To perform molecular docking and ADMET
analysis to determine the binding affinity and drug-likeness of NCE’s.

Materials and Methods::
The Multiple linear regression approach (MLR) method was utilised to generate the QSAR Model using the programme QSARINS v.2.2.4. For
molecular docking, the Autodock vina software was employed. While the Swiss ADME and ToxiM online tools were used to predict toxicity.

Results and Discussion::
The best models generated for 2D QSAR had correlation coefficients of R2= 0.9247 & Q2= 0.924 and for 3D QSAR, coefficients were R2 = 0.9297
and Q2 = 0.876. A novel series of 68 derivatives was designed based on QSAR investigations. Molecule C-58 has shown maximum binding affinity
in molecular docking as compared to the standard Ribociclib.

Conclusion::
Fifteen compounds have shown potential as CDK4 inhibitors based on docking studies, pharmacokinetic behavior and toxicity profile. The
maximum binding affinity was demonstrated by molecule C-58.
Kompetencje językowe i komunikacyjne dzieci/uczniów na poziomie przedszkolnym i wczesnoszkolnym w diagnozie nauczycielskiej-pedagogicznej. Rozwijanie funkcji językowych w sytuacji nauki zdalnej
Authors: Wieczór Elżbieta 
Published: November 2023

Tematyka artykułu skupia się wokół komunikacji językowej dziecka w wieku przedszkolnym i wczesnoszkolnym. Kompetencje językowe definiowane są jako kluczowe w rozwoju, a ich proces nabywania opisuje się w kontekście środowiska edukacyjnego i domowego. Określenie poziomu językowego rozwoju dziecka stanowi ważny obszar diagnozy pedagogicznej. Każdy nauczyciel wczesnej edukacji w codziennej obserwacji (dziecko w sytuacji zadaniowej i zabawowej) i relacji językowej z dzieckiem, staje się świadomym i kompetentnym diagnostą. Doświadczanie codzienności dziecka w sytuacji nauki zdalnej, pozwoliło zaobserwować i zdiagnozować, jak w okresie uczenia się on-line rozwija się język i komunikacja dziecka, manualność i grafomotoryka oraz świadomość pisma.
Tablet-Based Puzzle Game Intervention for Cognitive Function and Well-Being in Healthy Adults: Pilot Feasibility Randomized Controlled Trial
Authors: Urwyler Prabitha , Gupta Rajnish Kumar , Falkner Michael , Niklaus Joel , Müri René Martin , Nef Tobias 
Published: November 2023

Abstract

Background
Promoting cognitive health is key to maintaining cognitive and everyday functions and preventing the risk of cognitive impairment or dementia. Existing scientific evidence shows the benefits of various training modalities on cognition. One way to promote cognitive health is through engagement in cognitive activities (eg, board and video games).

Objective
This study aims to investigate the benefits of dynamic adaptive casual puzzle games on cognitive function and well-being in healthy adults and older people.

Methods
A total of 12 adults and older people (female participants: n=6; mean age 58.92, SD 10.28 years; range 46-75 years) were included in this pilot randomized controlled trial. This study used a crossover design with two phases (8 weeks each) and three measurement waves (pretest, midtest, and posttest). The participants were randomly allocated either to the control or experimental group. In the control group, participants read newspapers between the pre- and midtest, then switched to cognitive training with puzzle games. In the experimental group, the interventions were reversed. Baseline measurements (pretest) were collected before the intervention. The interventions were delivered on tablet computers and took place unsupervised at participants’ homes.

Results
The outcome measures included global cognitive function, higher cognitive function, and emotional well-being at 3 time points (pretest, midtest, and posttest) using standardized neuropsychological tests. The participants showed improvements in their visual attention and visuospatial measures after the puzzle game intervention.

Conclusions
The study showed that digital games are a feasible way to train cognition in healthy adults and older people. The algorithm-based dynamic adaption allows accommodations for persons with different cognitive levels of skill. The results of the study will guide future prevention efforts and trials in high-risk populations.
An Introduction to Faculty Diversity, Equity, and Inclusion for Excellence in Nurse Education: Literature Review
Authors: Ganek Emily , Sazon Romy Antonnette P , Gray Lauren , Sherry Daisy 
Published: November 2023

Background
The diversity of the world’s population is increasing, along with the health inequities of underrepresented minority populations. To provide high-quality care to all patients, nurses require an understanding of diversity, equity, and inclusion (DEI) as well as how to implement best practices. Nurse educators are the ones to lead the way for DEI education for students.

Objective
This paper aims to describe the findings of a literature review that introduces DEI concepts for excellence in nurse education and their related benefits. Best practices for actions to address DEI in nursing education will be described.

Methods
After institutional review board approval, a literature search yielded 61 articles using 15 distinct keywords in 4 global, peer-reviewed literature databases. Melynk and Fineout-Overholt’s (2023) Levels of Evidence guided the process of selecting 26 peer-reviewed articles and resources.

Results
Common themes for best practices in DEI were identified. These themes included recruiting underrepresented minority nursing faculty, incorporating DEI into an institution’s mission statement, addressing DEI topics in curricula, providing leadership, having a DEI strategic plan, developing education, developing data-based interventions, instilling policy change, partnering in outreach, targeting impact on hiring committees, recognizing DEI work, and providing mentorship.

Conclusions
In summary, this literature review provides several strategies to address DEI for nurse educators. Committing to DEI efforts and improving diversity in the nurse educator workforce are integral steps in improving the quality and inclusivity of nursing education and ultimately improving the health of our communities.
App Characteristics and Accuracy Metrics of Available Digital Biomarkers for Autism: Scoping Review
Authors: Ponzo Sonia , May Merle , Tamayo-Elizalde Miren , Bailey Kerri , Shand Alanna J , Bamford Ryan , Multmeier Jan , Griessel Ivan , Szulyovszky Benedek , Blakey William , Valentine Sophie , Plans David 
Published: November 2023

Background
Diagnostic delays in autism are common, with the time to diagnosis being up to 3 years from the onset of symptoms. Such delays have a proven detrimental effect on individuals and families going through the process. Digital health products, such as mobile apps, can help close this gap due to their scalability and ease of access. Further, mobile apps offer the opportunity to make the diagnostic process faster and more accurate by providing additional and timely information to clinicians undergoing autism assessments.

Objective
The aim of this scoping review was to synthesize the available evidence about digital biomarker tools to aid clinicians, researchers in the autism field, and end users in making decisions as to their adoption within clinical and research settings.

Methods
We conducted a structured literature search on databases and search engines to identify peer-reviewed studies and regulatory submissions that describe app characteristics, validation study details, and accuracy and validity metrics of commercial and research digital biomarker apps aimed at aiding the diagnosis of autism.

Results
We identified 4 studies evaluating 4 products: 1 commercial and 3 research apps. The accuracy of the identified apps varied between 28% and 80.6%. Sensitivity and specificity also varied, ranging from 51.6% to 81.6% and 18.5% to 80.5%, respectively. Positive predictive value ranged from 20.3% to 76.6%, and negative predictive value fluctuated between 48.7% and 97.4%. Further, we found a lack of details around participants’ demographics and, where these were reported, important imbalances in sex and ethnicity in the studies evaluating such products. Finally, evaluation methods as well as accuracy and validity metrics of available tools were not clearly reported in some cases and varied greatly across studies. Different comparators were also used, with some studies validating their tools against the Diagnostic and Statistical Manual of Mental Disorders criteria and others through self-reported measures. Further, while in most cases, 2 classes were used for algorithm validation purposes, 1 of the studies reported a third category (indeterminate). These discrepancies substantially impact the comparability and generalizability of the results, thus highlighting the need for standardized validation processes and the reporting of findings.

Conclusions
Despite their popularity, systematic evaluations and syntheses of the current state of the art of digital health products are lacking. Standardized and transparent evaluations of digital health tools in diverse populations are needed to assess their real-world usability and validity, as well as help researchers, clinicians, and end users safely adopt novel tools within clinical and research practices.