bluuebunny/crossref_metadata_2025_split huggingface dataset:
A proposed PMU-based voltage stability and critical bus detection method using artificial neural network
Authors: Putranto Lesnanto Multa , Azhar Izzuddin Fathin 
Published: January 2024

AbstractVoltage stability detection is currently still becoming the main issue in the modern integrated renewable energy power systems. To assess the voltage stability, the classical methods based on continuation power flow (CPF) technique were used to show nose curve. However, the classical methods require complete model of power system and long computation time. Data driven analysis and synchronized real time measurement technologies currently are developing in power systems monitoring, including the stability detection. The detection method is built based on the historical event model and uses the real time measurement as an input. For that reason, the algorithm to detect the voltage instability and critical bus is proposed using the artificial neural network (ANN) technique to represent the historical event model using the PMU measurement data. The ANN model architecture for this application is developed by creating seven hidden layers consisting of one normalization, four rectifier linear unit, one softmax and one sigmoid layer. To warrant the accuracy, the k-fold cross-validation is used. The algorithm is simulated on modified IEEE 14 test system which consider different loading scenario, line contingency, number of PMU and Photovoltaic (PV) integration. To mimic the actual historical data, the synthetic data is generated and labelled. The result shows that the proposed method can represent the complete power system model by giving high accuracy which for voltage stability detection is > 97% and critical buses detection is > 96% for all scenarios. Moreover, the required computation time is between 16 and 18 s per detection which makes the scalability to the real time detection is reasonable.
Relationship between effectiveness of asthma management and genetic variants in asthmatic Egyptian children
Authors: Ahmed Hoda H. , Farid Tarek M. , Hashish Maha M. A. Abo , Ibrahim Areef R. , Mustafa Amr M. , Wahby Aliaa Ahmed , Hassan Mirhane , Elsebaie Eman Hany , Ramadan Abeer , Mansour Sameh Abdelaziz 
Published: January 2024

Abstract
Background
Personalized asthma medicine research identifies critical genes like ADRB2 and ADH5 that affect disease and treatment outcomes, necessitating a deeper exploration of these genetic influences on asthma prevalence and management in Egyptian children. This study aimed to examine the relationship between asthma control and specific genetic variants in Egyptian children, focusing on four significant SNPs within four key genes.

Methods
A cross-sectional genetic study was conducted between December 2020 and May 2021 at two hospitals affiliated with Al-Azhar University to assess gene polymorphisms in adolescent asthmatic patients. Blood samples were taken from participants, with portions dedicated to DNA extraction and serum level measurements. The extracted DNA was then genotyped using the real-time PCR technique, and specific genotypes were identified based on their fluorescence characteristics.

Results
A total of 93 subjects were enrolled in the study. Cases (asthmatic children) had a significantly higher BMI than controls—healthy children—(33.65 ± 3.88 vs. 21.10 ± 3.48, p < 0.001). A notable distinction was observed in residence, with 30.6% of cases from urban areas versus 85.7% in controls (p < 0.001). Cases had a markedly higher incidence of familial asthma history (86.1% vs. 0.0%, p < 0.001), atopy (95.8% vs. 0.0%, p < 0.001), food allergies (80.6% vs. 9.5%, p < 0.001), and animal contact (79.2% vs. 14.3%, p < 0.001) compared to controls. The genetic marker rs4795399's CC allele was found in 10.0% of controls but not in any cases (p = 0.024), and the AA allele of rs7927044 was significantly more common in controlled asthmatics than in uncontrolled ones (p = 0.030).

Conclusion
The studied genetic variants were not significantly associated with asthma severity; however, patients with uncontrolled asthma were associated with significantly higher polymorphism of GG and AG alleles of rs7927044. Additionally, there was a significant difference between the asthmatic patients and healthy individuals in terms of the polymorphism of the rs4795399 TT allele.
Unusual site of echinococcosis: axillary hydatid cyst—a case report
Authors: Hammami Fatma , Koubaa Makram , Rekik Khaoula , Smaoui Fatma , Marrakchi Chakib , Ben Jemaa Mounir 
Published: January 2024

Abstract
Background
Echinococcosis is a multisystem disease that might affect all organs, especially the liver and the lungs among adults. Axillary hydatid cyst, an extremely uncommon disease, was rarely reported in the literature. We report herein a case of axillary hydatid cyst which revealed a disseminated hydatid disease among a previously healthy woman.

Case presentation
A previously healthy woman, aged 53 years old, presented with a painful mass in her right axillary region. Physical examination revealed a painful semi-mobile right axillary mass, of 12 cm in size. Thoracoabdominal computed tomography scan revealed numerous cystic lesions: right axillary, pulmonary, hepatic, pancreatic, splenic and intraperitoneal lesions. The diagnosis of disseminated hydatid disease was suspected in front of the cystic lesions and the positive serology result for hydatid disease. An excisional biopsy of the axillary mass lesion was performed, confirming the diagnosis of a hydatid cyst. The patient received albendazole after hospital discharge.

Conclusions
Although axillary hydatid cyst is an extremely uncommon disease, the diagnosis should be rule out in front of the presence of a mass in the axillary region. Imaging results associated with serological tests might suspect the diagnosis, which can only be confirmed with parasitological or/and histopathological examination. Its management include surgical and medical therapy.
Methods for scaling up an outreach intervention to increase colorectal cancer screening rates in rural areas
Authors: Coury Jennifer , Coronado Gloria , Currier Jessica J. , Kenzie Erin S. , Petrik Amanda F. , Badicke Brittany , Myers Emily , Davis Melinda M. 
Published: January 2024

Abstract
Background
Mailed fecal immunochemical test (FIT) outreach and patient navigation are evidence-based practices shown to improve rates of colorectal cancer (CRC) and follow-up in various settings, yet these programs have not been broadly adopted by health systems and organizations that serve diverse populations. Reasons for low adoption rates are multifactorial, and little research explores approaches for scaling up a complex, multi-level CRC screening outreach intervention to advance equity in rural settings.

Methods
SMARTER CRC, a National Cancer Institute Cancer Moonshot project, is a cluster-randomized controlled trial of a mailed FIT and patient navigation program involving 3 Medicaid health plans and 28 rural primary care practices in Oregon and Idaho followed by a national scale-up trial. The SMARTER CRC intervention combines mailed FIT outreach supported by clinics, health plans, and vendors and patient navigation for colonoscopy following an abnormal FIT result. We applied the framework from Perez and colleagues to identify the intervention’s components (including functions and forms) and scale-up dissemination strategies and worked with a national advisory board to support scale-up to additional organizations. The team is recruiting health plans, primary care clinics, and regional and national organizations in the USA that serve a rural population. To teach organizations about the intervention, activities include Extension for Community Healthcare Outcomes (ECHO) tele-mentoring learning collaboratives, a facilitation guide and other materials, a patient navigation workshop, webinars, and individualized technical assistance. Our primary outcome is program adoption (by component), measured 6 months after participation in an ECHO learning collaborative. We also assess engagement and adaptations (implemented and desired) to learn how the multicomponent intervention might be modified to best support broad scale-up.

Discussion
Findings may inform approaches for adapting and scaling evidence-based approaches to promote CRC screening participation in underserved populations and settings.

Trial registration
Registered at ClinicalTrials.gov (NCT04890054) and at the NCI’s Clinical Trials Reporting Program (CTRP no.: NCI-2021–01032) on May 11, 2021.
Comprehensive Genomic Analysis of Patients With Non–Small-Cell Lung Cancer Using Blood-Based Circulating Tumor DNA Assay: Findings From the BFAST Database of a Single Center in Taiwan
Authors: Wang Hsin-Yi , Ho Chao-Chi , Lin Yen-Ting , Liao Wei-Yu , Chen Chung-Yu , Shih Jin-Yuan , Yu Chong-Jen 
Published: January 2024

PURPOSE The Blood First Assay Screening Trial (BFAST) is a prospective study using next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) in treatment-naïve advanced/metastatic non–small-cell lung cancer (NSCLC). We compared liquid biopsy to tissue testing and analyzed genomic alterations in Taiwanese patients with NSCLC using the BFAST database. MATERIALS AND METHODS A total of 269 patients underwent FoundationOne Liquid Companion Diagnostic (F1LCDx) assay at the National Taiwan University Hospital, of whom 264 underwent tissue-based genetic testing also. We analyzed the actionable mutations and the concordance between tissue-based genetic testing, which was limited to EGFR, ALK, ROS1, and BRAF, in a real-life clinical setting and blood-based NGS in the clinical trial. Additionally, we analyzed the co-occurring genomic alterations from the blood-based ctDNA assay. RESULTS A total of 76.2% patients showed actionable mutations. Standard tissue testing did not detect known driver alterations in about 22.7% of the patients (sensitivity, 70.24%). Liquid NGS detected additional mutations ( RET, KRAS, MET, and ErbB2) in 14% of the patients, which went undetected by the standard-of-care testing. The complementary use of ctDNA NGS increased the detection rate by 42%. The F1LCDx assay had a sensitivity of 83.41%. Lower tumor and metastasis stages predicted nondetected blood-based NGS ctDNA results. Common co-occurring mutations in the blood-based NGS ctDNA assay were TP53, DNMT3A, TET2, PIK3CA, CTNNB1, and RB1. Among the patients with EGFR-mutated NSCLC, TET2 co-occurring alterations correlated with shorter progression-free survival of EGFR tyrosine kinase inhibitor treatment. CONCLUSION NGS ctDNA analysis in comprehensive genetic testing improves actionable mutation identification, vital for treating Asian NSCLC cases with high actionable mutation rates. Lower stages correlated with undetected blood-based NGS ctDNA assay results.
Loss-of-Resistance Versus Dynamic Pressure-Sensing Technology for Successful Placement of Thoracic Epidural Catheters: A Randomized Clinical Trial
Authors: Ranganath Yatish S. , Ramanujam Vendhan , Al-Hassan Qasim , Sibenaller Zita , Seering Melinda S. , Singh Tejinder Singh Swaran , Punia Sangini , Parra Michelle C. , Wong Cynthia A. , Sondekoppam Rakesh V. 
Published: January 2024

BACKGROUND:
The traditional loss-of-resistance (LOR) technique for thoracic epidural catheter placement can be associated with a high primary failure rate. In this study, we compared the traditional LOR technique and dynamic pressure-sensing (DPS) technology for primary success rate and secondary outcomes pertinent to identifying the thoracic epidural space.

METHODS:
This pragmatic, randomized, patient- and assessor-blinded superiority trial enrolled patients ages 18 to 75 years, scheduled for major thoracic or abdominal surgeries at a tertiary care teaching hospital. Anesthesiology trainees (residents and fellows) placed thoracic epidural catheters under faculty supervision and rescue. The primary outcome was the success rate of thoracic epidural catheter placement, evaluated by the loss of cold sensation in the thoracic dermatomes 20 minutes after injecting the epidural test dose. Secondary outcomes included procedural time, ease of catheter placement, the presence of a positive falling meniscus sign, early hemodynamic changes, and unintended dural punctures. Additionally, we explored outcomes that included number of attempts, needle depth to epidural space, need for faculty to rescue the procedure from the trainee, patient-rated procedural discomfort, pain at the epidural insertion site, postoperative pain scores, and opioid consumption over 48 hours.

RESULTS:
Between March 2019 and June 2020, 133 patients were enrolled; 117 were included in the final analysis (n = 57 for the LOR group; n = 60 for the DPS group). The primary success rate of epidural catheter placement was 91.2% (52 of 57) in the LOR group and 96.7% (58 of 60) in the DPS group (95% confidence interval [CI] of difference in proportions: −0.054 [−0.14 to 0.03]; P = .264). No difference was observed in procedural time between the 2 groups (median interquartile range [IQR] in minutes: LOR 5.0 [7.0], DPS 5.5 [7.0]; P = .982). The number of patients with epidural analgesia onset at 10 minutes was 49.1% (28 of 57) in the LOR group compared to 31.7% (19 of 60) in the DPS group (P = .062). There were 2 cases of unintended dural punctures in each group. Other secondary or exploratory outcomes were not significantly different between the groups.

CONCLUSIONS:
Our trial did not establish the superiority of the DPS technique over the traditional LOR method for identifying the thoracic epidural space (Clinicaltrials.gov identifier: NCT03826186).
Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Patients With Severe Renal Impairment: A Randomized, Double-Blinded Study
Authors: Oh Matthew W. , Mohapatra Shweta G. , Pak Taylor , Hermawan Aundree , Chen Chieh-An , Thota Bhavana , Chen Joy , Siu Eric , Park Jenny , Moon Tiffany S. 
Published: January 2024

BACKGROUND:
Sugammadex is not advised for patients with severe renal impairment, but has been shown in a variety of other populations to be superior to neostigmine for reversal of neuromuscular blockade. The objective of this study was to determine if reversal of rocuronium-induced neuromuscular blockade with sugammadex versus reversal of cisatracurium-induced neuromuscular blockade with neostigmine results in a faster return to a train-of-four ratio (TOFR) ≥90% in patients with severe renal impairment.

METHODS:
We conducted a prospective, randomized, blinded, controlled trial at a large county hospital. A total of 49 patients were enrolled. Inclusion criteria included patients age ≥18, American Society of Anesthesiologists (ASA) physical status III and IV, with a creatinine clearance <30 mL/min, undergoing general anesthesia with expected surgical duration ≥2 hours and necessitating neuromuscular blockade. Subjects received either cisatracurium 0.2 mg/kg or rocuronium 0.6 mg/kg for induction of anesthesia to facilitate tracheal intubation. Subjects were kept at moderate neuromuscular blockade during surgery and received either 2 mg/kg sugammadex or 50 µg/kg neostigmine with 10 µg/kg glycopyrrolate for reversal of neuromuscular blockade. Neuromuscular monitoring was performed with electromyography (TwitchView), and the TOFR was recorded every minute after administration of the reversal agent. The time from administration of neuromuscular reversal until the patient reached a TOFR ≥90% was recorded as the primary outcome.

RESULTS:
The mean time to recovery of TOFR ≥90% was significantly faster with sugammadex at 3.5 (±1.6) min compared with neostigmine at 14.8 (±6.1) min (P < .0001; mean difference, 11.3 minutes; 95% confidence interval [CI], 9.0–13.5 minutes). There were no major adverse events in either group.

CONCLUSIONS:
In patients with severe renal impairment, neuromuscular blockade with rocuronium followed by reversal with sugammadex provides a significantly faster return of neuromuscular function compared to cisatracurium and neostigmine, without any major adverse effects.
Does Aerobic Exercise Increase Skeletal Muscle Mass in Female and Male Adults?
Authors: ROSS ROBERT , JOHN EMILY , MCGLORY CHRIS , DAVIDSON LANCE E. , STOTZ PAULA J. 
Published: January 2024

ABSTRACT

Introduction
It is uncertain whether aerobic exercise in the form of walking contributes to the preservation or increase in total or regional skeletal muscle mass (SMM).

Purpose
This study aimed to determine the effects of aerobic exercise on total and regional (upper body verses leg SMM) in male (n = 105) and female (n = 133) adults with overweight and obesity.

Methods
A retrospective analysis of data from four randomized controlled trials. Participants included those who completed the given trial (control, n = 63; intervention, n = 175) and with complete magnetic resonance imaging (MRI) measured adipose tissue and SMM pre- and postintervention. Macronutrient intake was assessed for a subsample of participants. Supervised exercise was performed by walking on a treadmill for durations ranging from 12 to 24 wk at intensities between 50% and 75% of V̇O2peak.

Results
All MRI-measured adipose tissue depots were reduced, and cardiorespiratory fitness was increased by aerobic exercise compared with controls (P < 0.001). Independent of baseline SMM, aerobic exercise was associated with a small reduction (estimated mean difference ± standard error) in whole-body SMM (−0.310 ± 0.150 kg, P = 0.039) and upper body SMM (−0.273 ± 0.121 kg, P = 0.025) compared with control. No between-group difference was observed for change in leg SMM (P > 0.10). A negative association was observed between the relative change in body weight and change in total (R
2 = 0.37, P < 0.001), upper body (R
2 = 0.21, P < 0.001), and leg SMM (R
2 = 0.09, P = 0.701). The SMM-to-adipose tissue ratio increased in response to aerobic exercise and was positively associated with weight loss (P < 0.001). Change in SMM was not associated with dietary protein intake (P > 0.10).

Conclusions
Aerobic exercise performed while walking preserves, but does not increase, SMM in exercising muscle of adults. SMM not directly targeted by aerobic exercise may not be maintained.
More Variability in Tibialis Anterior Function during the Adduction of the Foot than Dorsiflexion of the Ankle
Authors: AMIRIDIS IOANNIS G. , KANNAS THEODOROS , SAHINIS CHRYSOSTOMOS , NEGRO FRANCESCO , TRYPIDAKIS GEORGIOS , KELLIS ELEFTHERIOS , ENOKA ROGER M. 
Published: January 2024

ABSTRACT

Introduction
The aim of the study was to compare maximal force, force steadiness, and the discharge characteristics of motor units in the tibialis anterior (TA) muscle during submaximal isometric contractions for ankle dorsiflexion and adduction of the foot.

Methods
Nineteen active young adults performed maximal and submaximal isometric dorsiflexion and adduction contractions at five target forces (5%, 10%, 20%, 40%, and 60% maximal voluntary contraction [MVC]). The activity of motor units in TA was recorded by high-density EMG.

Results
The maximal force was similar between dorsiflexion and adduction, despite EMG amplitude for TA being greater (P < 0.05) during dorsiflexion than adduction. Τhe coefficient of variation (CV) for force (force steadiness) during dorsiflexion was always less (P < 0.05) than during adduction, except of 5% MVC force. No differences were observed for mean discharge rate; however, the regression between the changes in discharge rate relative to the change of force was significant for dorsiflexion (R
2 = 0.25, P < 0.05) but not for adduction. Discharge variability, however, was usually less during dorsiflexion. The CV for interspike interval was less (P < 0.05) at 10%, 20%, and 40% MVC but greater at 60% MVC during dorsiflexion than adduction. Similarly, the SD values of the filtered cumulative spike train of the motor units in TA were less (P < 0.05) at 5%, 10%, 20%, and 40% MVC during dorsiflexion than adduction.

Conclusions
Although the mean discharge rate of motor units in TA was similar during foot adduction and ankle dorsiflexion, discharge variability was less during dorsiflexion resulting in less accurate performance of the steady adduction contractions. The neural drive to bifunctional muscles differs during their accessory function, which must be considered for training and rehabilitation interventions.
Lack of Proprioceptive Strategy Modulation Leads to At-Risk Biomechanics for Anterior Cruciate Ligament in Healthy Athletes
Authors: PICOT BRICE , LEMPEREUR MATHIEU , MOREL BAPTISTE , FORESTIER NICOLAS , RÉMY-NÉRIS OLIVIER 
Published: January 2024

ABSTRACT

Introduction
Anterior cruciate ligament (ACL) injuries are frequent in handball, and altered sensory integration may contribute to increased injury risk. Recent evidence showed that proprioceptive postural control strategies differ among athletes. The aim of this study was to evaluate the relationship between proprioceptive strategy and biomechanics during side-cutting maneuvers.

Methods
A total of 47 handball players performed anticipated and unanticipated cutting tasks. Their postural proprioceptive strategy was then characterized according to the perturbation of the center of pressure displacement generated by the muscle vibration on a firm and foam surface. Individuals able to reweight proprioception from ankle to lumbar signals according to the stability of the support were defined as flexible. Conversely, athletes maintaining an ankle-steered strategy on foam surface were characterized as rigid. Statistical parametric mapping analysis was used to compare pelvic and lower limb side-cutting kinematics, kinetics, and EMG activity from seven muscles 200 ms before and after initial contact (IC) using a two-way ANOVA (group–condition).

Results
Twenty athletes (11 females and 9 males, 18.5 yr) were characterized as flexible and 20 athletes (12 females and 8 males, 18.9 yr) as rigid. No interaction between condition and proprioceptive profile was observed. More ipsilateral pelvic tilt before IC and lower vastus lateralis (VL) activity immediately after IC was observed during CUTant. When comparing proprioceptive strategy, rigid individuals exhibited less preactivity of the semitendinosus (P < 0.001) and higher VL activity (P = 0.032). Conversely, rigid showed higher gluteus medius preactivity (P < 0.05) and higher VL activity 100 ms after IC (P < 0.001). Ankle was also more internally rotated before and during the stance phase (P < 0.05) among rigid athletes.

Conclusions
Rigid handball players exhibited at-risk determinants for anterior cruciate ligament injuries during side-cutting maneuvers.