bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charged spinning and magnetized test particles orbiting quantum improved charged black holes
Authors: Ladino Jose Miguel , Benavides-Gallego Carlos A. , Larrañaga Eduard , Rayimbaev Javlon , Abdulxamidov Farrux 
Published: November 2023

AbstractIn the present work, we aimed to investigate the dynamics of spinning charged and magnetized test particles around both electrically and magnetically charged quantum-improved black holes. We derive the equations of motion for charged spinning test particles using the Mathisson-Papapetrou-Dixon ***equations with the Lorentz coupling term. The radius of innermost stable circular orbits (ISCOs), specific angular momentum, and energy for charged spinless, uncharged spinning, and charged spinning test particles around the charged and non-charged quantum-improved black holes are analyzed separately. We found that the quantum parameter increases the maximum spin value, $$s_\textrm{max}$$

s
max

, which leads to the nonphysical motion (superluminal motion) of the charged spinning test particle. In contrast, the black hole charge decreases its value. We also found that, in contrast to the Reissner Nordström black hole, spinning charged test particles in the quantum-improved charged black hole have higher $$s_\textrm{max}$$

s
max

; moreover, positively charged spinning particles can have higher values of $$s_\textrm{max}$$

s
max

near the extreme black hole cases when compared with uncharged spinning particles. Finally, we investigate the magnetized test particle’s dynamics in the spacetime of a quantum-improved magnetically charged black hole in Quantum Einstein Gravity using the Hamilton–Jacobi equation. We show that the presence of $$\omega $$
ω
increases the maximum value of the effective potential and decreases the minimum energy and angular momentum of magnetized particles at their circular orbits. We found an upper constraint in the black hole charge at the ISCO.
Aircraft Cockpit Interaction in Virtual Reality with Visual, Auditive, and Vibrotactile Feedback
Authors: Auer Stefan , Anthes Christoph , Reiterer Harald , Jetter Hans-Christian 
Published: November 2023

Safety-critical interactive spaces for supervision and time-critical control tasks are usually characterized by many small displays and physical controls, typically found in control rooms or automotive, railway, and aviation cockpits.
Using Virtual Reality (VR) simulations instead of a physical system can significantly reduce the training costs of these interactive spaces without risking real-world accidents or occupying expensive physical simulators.
However, the user's physical interactions and feedback methods must be technologically mediated.
Therefore, we conducted a within-subjects study with 24 participants and compared performance, task load, and simulator sickness during training of authentic aircraft cockpit manipulation tasks.
The participants were asked to perform these tasks inside a VR flight simulator (VRFS) for three feedback methods (acoustic, haptic, and acoustic+haptic) and inside a physical flight simulator (PFS) of a commercial airplane cockpit.
The study revealed a partial equivalence of VRFS and PFS, control-specific differences input elements, irrelevance of rudimentary vibrotactile feedback, slower movements in VR, as well as a preference for PFS.
Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na
+
Channel (ENaC)
Authors: Duan Xin-Peng , Xiao Yu , Su Xiao-Tong , Zheng Jun-Ya , Gurley Susan , Emathinger Jacqueline , Yang Chao-Ling , McCormick James , Ellison David H. , Lin Dao-Hong , Wang Wen-Hui 
Published: November 2023

BACKGROUND:
Kir4.2 and Kir4.1 play a role in regulating membrane transport in the proximal tubule (PT) and in the distal-convoluted-tubule (DCT), respectively.

METHODS:
We generated kidney-tubule-specific-AT1aR-knockout (Ks-AT1aR-KO) mice to examine whether renal AT1aR regulates Kir4.2 and Kir4.1.

RESULTS:

Ks-AT1aR-KO mice had a lower systolic blood pressure than

Agtr1a
flox/flox

(control) mice. Ks-AT1aR-KO mice had a lower expression of NHE
3
(Na
+
/H
+
-exchanger 3) and Kir4.2, a major Kir-channel in PT, than

Agtr1a
flox/flox

mice. Whole-cell recording also demonstrated that the membrane potential in PT of Ks-AT1aR-KO mice was lesser negative than

Agtr1a
flox/flox

mice. The expression of Kir4.1 and Kir5.1, Kir4.1/Kir5.1-mediated K
+
currents of DCT and DCT membrane potential in Ks-AT1aR-KO mice, were similar to

Agtr1a
flox/flox

mice. However, angiotensin II perfusion for 7 days hyperpolarized the membrane potential in PT and DCT of the control mice but not in Ks-AT1aR-KO mice, while angiotensin II perfusion did not change the expression of Kir4.1, Kir4.2, and Kir5.1. Deletion of AT1aR did not significantly affect the expression of αENaC (epithelial Na
+
channel) and βENaC but increased cleaved γENaC expression. Patch-clamp experiments demonstrated that deletion of AT1aR increased amiloride-sensitive Na
+
-currents in the cortical-collecting duct but not in late-DCT. However, tertiapin-Q sensitive renal outer medullary potassium channel currents were similar in both genotypes.

CONCLUSIONS:
AT1aR determines the baseline membrane potential of PT by controlling Kir4.2 expression/activity but AT1aR is not required for determining the baseline membrane potential of the DCT and Kir4.1/Kir5.1 activity/expression. However, AT1aR is required for angiotensin II–induced hyperpolarization of basolateral membrane of PT and DCT. Deletion of AT1aR had no effect on baseline renal outer medullary potassium channel activity but increased ENaC activity in the CCD.
The unique neural signature of your trip: Functional connectome fingerprints of subjective psilocybin experience
Authors: Tolle Hanna M. , Farah Juan Carlos , Mallaroni Pablo , Mason Natasha L. , Ramaekers Johannes G. , Amico Enrico 
Published: November 2023

Abstract
The emerging neuroscientific frontier of brain fingerprinting has recently established that human functional connectomes (FCs) exhibit fingerprint-like idiosyncratic features, which map onto heterogeneously distributed behavioral traits. Here, we harness brain-fingerprinting tools to extract FC features that predict subjective drug experience induced by the psychedelic psilocybin. Specifically, in neuroimaging data of healthy volunteers under the acute influence of psilocybin or a placebo, we show that, post psilocybin administration, FCs become more idiosyncratic owing to greater intersubject dissimilarity. Moreover, whereas in placebo subjects idiosyncratic features are primarily found in the frontoparietal network, in psilocybin subjects they concentrate in the default mode network (DMN). Crucially, isolating the latter revealed an FC pattern that predicts subjective psilocybin experience and is characterized by reduced within-DMN and DMN-limbic connectivity, as well as increased connectivity between the DMN and attentional systems. Overall, these results contribute to bridging the gap between psilocybin-mediated effects on brain and behavior, while demonstrating the value of a brain-fingerprinting approach to pharmacological neuroimaging.
Ritual Chairs of Circumcision Ceremonies: Reassessing Meaning through Materiality
Authors: Shacham-Rosby Chana 
Published: November 2023

Abstract
This essay will showcase a process of contextualizing a Jewish ritual object through synthesizing a range of sources. The object at the center of this research is the chair in the context of the circumcision ceremony in medieval Ashkenaz and the early modern Ashkenazi diaspora. The two ceremonial chairs are designated, respectively, for the ba′al brit, who holds the infant, and Elijah the Prophet, whose association with circumcision will be explored. The essay will present the central themes that medieval Ashkenazi Jews wished to highlight during the ceremony and suggest how these themes were reflected and communicated in the affordances of the chair.
Two-Step Hyperparameter Optimization Method: Accelerating Hyperparameter Search by Using a Fraction of a Training Dataset
Authors: Yu Sungduk , Ma Po-Lun , Singh Balwinder , Silva Sam , Pritchard Mike 
Published: November 2023

Abstract
Hyperparameter optimization (HPO) is an important step in machine learning (ML) model development, but common practices are archaic—primarily relying on manual or grid searches. This is partly because adopting advanced HPO algorithms introduces added complexity to the workflow, leading to longer computation times. This poses a notable challenge to ML applications, as suboptimal hyperparameter selections curtail the potential of ML model performance, ultimately obstructing the full exploitation of ML techniques. In this article, we present a two-step HPO method as a strategic solution to curbing computational demands and wait times, gleaned from practical experiences in applied ML parameterization work. The initial phase involves a preliminary evaluation of hyperparameters on a small subset of the training dataset, followed by a reevaluation of the top-performing candidate models postretraining with the entire training dataset. This two-step HPO method is universally applicable across HPO search algorithms, and we argue it has attractive efficiency gains. As a case study, we present our recent application of the two-step HPO method to the development of neural network emulators for aerosol activation. Although our primary use case is a data-rich limit with many millions of samples, we also find that using up to 0.0025% of the data—a few thousand samples—in the initial step is sufficient to find optimal hyperparameter configurations from much more extensive sampling, achieving up to 135× speedup. The benefits of this method materialize through an assessment of hyperparameters and model performance, revealing the minimal model complexity required to achieve the best performance. The assortment of top-performing models harvested from the HPO process allows us to choose a high-performing model with a low inference cost for efficient use in global climate models (GCMs).
COVID-19 Vaccine Accessibility, Perceptions, and Attitudes in the LGBTQ+ Community
Authors: Traister Tyler 
Published: November 2023

Background: Lesbian, gay, bisexual, transgender, and queer populations have historically experienced challenges accessing, trusting, and receiving health care services, which can negatively impact successful uptake of the COVID-19 vaccine series among this population. Objective: This research aimed to examine the perceptions and attitudes regarding the acceptability, accessibility, and efficacy of the COVID-19 vaccine among persons who self-identify within this community Methods: A multidisciplinary, community-focused mixed-methods study was conducted. The quantitative portion of the study was conducted via an online survey throughout the United States for 2 months. The quantitative portion of the study consisted of multiple online focus group sessions after the completion of the survey. Results: The online survey had an sample of 3868 participants, with 31 participants in the focus groups. High levels of acceptability toward COVID-19 vaccines were found within this community. Concerns highlighted included the need for culturally competent care, side effects of the vaccine, and unknown effects of the vaccine with hormone replacement therapy. Racial and ethnic minority, transgender, and nonbinary participants reported higher levels of uncertainty about vaccination. Conclusion: Findings demonstrate that most lesbian, gay, bisexual, transgender, and queer individuals felt comfortable with the COVID-19 vaccine, had a positive experience with the vaccination process, and believe that the vaccine can protect them and others from COVID-19. When developing future COVID-19 vaccination strategies and rollouts, public health officials should consider prioritizing lesbian, gay, bisexual, transgender, and queer individuals and other marginalized populations by partnering with local organizations to identify trusted organizations.
Autobiographical Cerebral Network Activation in Older Adults Before and After Reminiscence Therapy: A Preliminary Report
Authors: Viard Armelle , Allen Andrew P. , Doyle Caoilainn M. , Naveau Mikaël , Bokde Arun L. W. , Platel Hervé , Eustache Francis , Commins Sean , Roche Richard A. P. 
Published: November 2023

Introduction Reminiscence therapy (RT), which engages individuals to evoke positive memories, has been shown to be effective in improving psychological well-being in older adults suffering from PTSD, depression, and anxiety. However, its impact on brain function has yet to be determined. This paper presents functional magnetic resonance imaging (fMRI) data to describe changes in autobiographical memory networks (AMN) in community-dwelling older adults. Methods This pilot study used a within-subject design to measure changes in AMN activation in 11 older adults who underwent 6 weeks of RT. In the scanner, participants retrieved autobiographical memories which were either recent or remote, rehearsed or unrehearsed. Participants also underwent a clinical interview to assess changes in memory, quality of life, mental health, and affect. Findings Compared to pretreatment, anxiety decreased (z = −2.014, p = .040) and activated significant areas within the AMN, including bilateral medial prefrontal cortex, left precuneus, right occipital cortex, and left anterior hippocampus. Conclusion Although RT had subtle effects on psychological function in this sample with no evidence of impairments, including depression at baseline, the fMRI data support current thinking of the effect RT has on the AMN. Increased activation of right posterior hippocampus following RT is compatible with the Multiple Trace Theory Theory (Nadel & Moscovitch, 1997).
Application of tumor microparticles in tumor prevention and treatment
Authors: Sun Weiwei , Xu Pingwei , Pan Pengtao , Guo Sheng , Liu Rui , Ji Guojie , Hu Huanhuan , Li Weidong , Dai Lili 
Published: November 2023

AbstractTumor microparticles (T-MPs) are vesicles released from tumor cells when they receive apoptotic or stimuli signals. T-MPs, which contain some proteins, lipids and nucleic acids from tumor cells, contribute to the exchange of material, energy and information between cells. T-MPs contain both tumor antigens and innate immunostimulatory signals, making T-MPs as a new form of tumor vaccine. Meanwhile, T-MPs can be used as natural carriers to transport ‘‘cargoes’’, such as chemotherapy drugs, oncolytic viruses, nucleic acids, and metal nanoparticles to treat tumors. In addition, T-MPs enhance the effect of chemotherapy. This review introduces the application of T-MPs as vaccines, delivery systems and chemosensitizers in tumor prevention and treatment, with a focus on the mechanisms, clinical applications, and influencing factors of drug-loaded T-MPs in tumor treatment.
Evaluation of clinical efficacy, adverse reactions, and safety of PD-1 inhibitors combined with chemotherapy when treating advanced gastric cancer
Authors: Huang Xue , He Du , Lai Lin , Chen Jun , Zhang Yukun , Mao Huilin 
Published: November 2023

Abstract
Objective
This paper aimed to assess the clinical efficacy, adverse reactions, and safety of employing PD-1 inhibitors in conjunction with chemotherapy as a treatment strategy for advanced gastric cancer (GC).

Methods
Ninety patients with advanced GC from January 2020 to December 2021 were divided into the research group (n = 45) and the control group (n = 45). The control group was treated with apatinib and tigio. The study group was treated with PD-1 inhibitor combined with apatinib and tigio. The remission rate (RR), disease control rate (DCR), overall survival (OS), Eastern Oncology Collaborative Group Physical Status Assessment (ECOG-PS) score, EORTCQLQ-C30 (v3.0) score, and incidence of adverse reactions were compared between the two groups.

Results
The research group exhibited improved outcomes in several key metrics relative to the control group. Specifically, the RR, DCR, and OS were notably higher in the research group. Additionally, the ECOG-PS score was significantly reduced, indicating better performance. At a median follow-up of 8.7 months, the research group’s functional and total health scores on the EORTC QLQ-C30 (v3.0) scale had seen significant improvement compared to their initial scores and were also superior to the control group’s scores. Importantly, both groups demonstrated comparable incidence rates for adverse reactions, with no significant difference observed (P > 0.05).

Conclusion
PD-1 inhibitor combined with chemotherapy was more effective when treating patients with advanced GC. It was more beneficial to enhance the patient’s condition, promote survival time, and improve physical status and life quality. In addition, the adverse reactions could be controlled.
Prenatal diagnosis and perinatal outcomes of twin pregnancies disharmonious for one fetus with nuchal translucency above the 95th percentile
Authors: Wang You , Zhou Hang , Fu Fang , Cheng Ken , Huang Ruibin , Li Ru , Li Dongzhi , Liao Can 
Published: November 2023

Abstract
Objective
To assess prenatal diagnosis and pregnancy outcomes in twin pregnancies where one fetus has nuchal translucency (NT) above the 95th percentile.

Method
In this retrospective analysis, 130 twin pregnancies (260 fetuses) in which one twin had an NT measurement above the 95th percentile while that of the other twin was normal were analyzed. Prenatal diagnostic results such as G bands, chromosomal microarray analysis, ultrasound findings, and pregnancy outcomes were reviewed.

Results
Karyotype analysis and CMA results revealed that 15 (15.6 percent, 15/96) fetuses exhibited chromosomal abnormalities and that 13 fetuses were Variant of Uncertain Significance. Chromosome abnormalities were detected at a rate of 8.9% (5/56) in the DCT group and 25.0% (10/40) in the MCT group (p = 0.033, X2 = 4.571). 2 fetuses in DCT (3.9 percent, 2/51) and 4 fetuses in MCT (13.3 percent, 4/30) (p = 0.187) revealed structural abnormalities among the cases with normal prenatal diagnosis. Fetuses in the DCT group had an overall survival rate of 75.4 percent (95/126), whereas those in the MCT group had a survival rate of 60.4 percent (81/134) (p = 0.01, X2 = 6.636). According to the findings of Logistics regression analysis, NT thickening, maternal age and method of conception were all significant risk factors for chromosome abnormalities.

Conclusion
In twin pregnancies with one fetus with NT above the 95th percentile, the prevalence of fetal structural abnormalities of the MCT group and the DCT group were comparable. Pregnant women’s age and mode of pregnancy are risk factors for chromosomal abnormalities.
Effective biosynthesis of 2,5-furandicarboxylic acid from 5-hydroxymethylfurfural via a bi-enzymatic cascade system using bacterial laccase and fungal alcohol oxidase
Authors: Yang Fan , Liu Jiashu , Li Bianxia , Li Huanan , Jiang Zhengbing 
Published: November 2023

Abstract
Background
As a cost-effective and eco-friendly approach, biocatalysis has great potential for the transformation of 5-hydroxymethylfurfural (HMF) into 2,5-furandicarboxylic acid (FDCA). However, the compatibility of each enzyme in the cascade reaction limits the transformation efficiency of HMF to FDCA.

Results
Coupled with an alcohol oxidase from Colletotrichum gloeosporioides (CglAlcOx), this study aims to study the potential of bacterial laccase from Bacillus pumilus (BpLac) in an enzymatic cascade for 2,5-furandicarboxylic acid (FDCA) biosynthesis from 5-hydroxymethylfurfural (HMF). BpLac showed 100% selectivity for HMF oxidation and generated 5-hydroxymethyl-2-furancarboxylic acid (HMFCA). CglAlcOx was capable of oxidizing HMFCA to 2-formyl-5-furancarboxylic acid (FFCA). Both BpLac and CglAlcOx could oxidize FFCA to FDCA. At the 5 mM scale, a complete transformation of HMF with a 97.5% yield of FDCA was achieved by coupling BpLac with CglAlcOx in the cascade reaction. The FDCA productivity in the reaction was 5.3 mg/L/h. Notably, BpLac could alleviate the inhibitory effect of FFCA on CglAlcOx activity and boost the transformation efficiency of HMF to FDCA. Moreover, the reaction was scaled up to 40 times the volume, and FDCA titer reached 2.6 mM with a yield of 58.77% at 168 h.

Conclusions
This work provides a candidate and novel insight for better design of an enzymatic cascade in FDCA production.
Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke
Authors: Gao Hui-min , Chen Hao , Cui Gui-Yun , Hu Jin-Xia 
Published: November 2023

AbstractThe blood-brain barrier (BBB) serves as a defensive line protecting the central nervous system, while also maintaining micro-environment homeostasis and inhibiting harmful materials from the peripheral blood. However, the BBB’s unique physiological functions and properties make drug delivery challenging for patients with central nervous system diseases. In this article, we briefly describe the cell structure basis and mechanism of action of the BBB, as well as related functional proteins involved. Additionally, we discuss the various mechanisms of BBB damage following the onset of an ischemic stroke, and lastly, we mention several therapeutic strategies accounting for impairment mechanisms. We hope to provide innovative ideas for drug delivery research via the BBB.
Trends in teicoplanin loading dose implementation from 2010 to 2019 and evaluation of safety and efficacy factors: a retrospective cohort study based on a Japanese administrative claims database
Authors: Goto Ryota , Muraki Yuichi , Inose Ryo , Ichii Moeno , Sawada Keisuke , Mizuno Kanako , Koizumi Ryuji , Tsuzuki Shinya , Ishikane Masahiro , Ohmagari Norio 
Published: November 2023

Abstract
Background
The loading dose of teicoplanin (TEIC) is recommended for implementation. However, there is significant discrepancy between the dose settings in the package insert and, in the guidelines, and the actual status of loading doses in Japan is unclear. Furthermore, TEIC causes liver injury as side effect. Although the risk of developing liver injury has not been reported to be increased following a loading dose based on the guidelines, there is a lack of reports in large populations. Therefore, we evaluated the trend in the loading dose and factors affecting the efficacy and safety of TEIC administration.

Methods
A Japanese administrative claims database was used in this study. Trends in loading doses were evaluated in target populations administered TEIC between 2010 and 2019. Patient characteristics were adjusted by propensity score matching based on the guideline group (total dose of 3 days > 1,600 mg) and non-guideline group (≤ 1,600 mg) of the loading dose. Finally, univariable and multivariable conditional logistic regression analysis was performed to evaluate factors affecting 30-day mortality and liver injury.

Results
A total of 10,030 patients were selected based on these criteria. The proportion of loading doses based on the recommended guidelines showed an increase over time, regardless of the implementation of therapeutic drug monitoring (TDM), but especially so in cases where TDM was implemented, the loading doses were administered in accordance with the recommendations of the guidelines. Conditional logistic regression analysis showed a relationship between drug management and guidance fees (odds ratio [OR]: 0.45, 95% confidence interval [CI]: 0.36‒0.55), a reimbursement indicating pharmacist intervention, and a reduction in 30-day mortality. In addition, loading doses based on the recommended guidelines had no influence on liver injury, and other factors were not significantly associated with increased incidence of liver injury.

Conclusion
Thus, this study implies the benefits of pharmacological management as indicated by drug management and guidance fee and supports the implementation of loading doses based on the guideline on TEIC administration.