bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Curing Time Komposit Serat Karbon Pada Filler Hollow Glass Microsphere (HGM) 10 % Menggunakan Metode RSM
Authors: Yuliyanto Yuliyanto , Zulfitriyanto Zulfitriyanto , Subarkah Imam 
Published: February 2025

Komposit adalah suatu jenis material atau material baru yang terbuat dari hasil rekayasa, terdiri dari dua bahan atau lebih, tersusun atas serat sebagai penguat dan matrik sebagai perekat atau pengikat serat. Serat karbon (carbon fiber) merupakan serat sintetis yang memiliki ukuran sangat tipis sekitar 0,1 mm yang sangat kuat dan ringan. Penelitian ini bertujuan untuk mengetahui pengaruh curring time dan parameter lainnya terhadap kekuatan lentur pada komposit serat karbon dengan Filler Hollow Glass Microsphere (HGM). Analisis data menggunakan Response Surface Methodology (RSM). Hasil uji lentur rata-rata tertinggi terdapat pada pengujian 1 dengan parameter persentase serat 30%, panjang serat 100 mm dan waktu curing 6 jam sebesar 212 MPa. pengujiaan rata-rata terendah terdapat pada pengujian ke 20, dengan parameter persentase serat 10%, panjang serat 100 mm dan waktu curing 6 jam sebesar 72,5 MPa. kenaikan nilai curing time akan menghasilkan kekuatan lentur menjadi menurun. Karena semakin lama proses caring time maka serat karbon semakin keras dan getas. Pengaruh lainya yaitu serat mengalami penyusutan dan mengecil sehingga akan membentuk void atau lobang kecil antara serat dan matrik. Pada Persentase serat yang lebih banyak mempengaruhi hasil kekuatan lentur menjadi lebih kuat. Karena gaya yang melawan pada saat proses pengujian lebih banyak dan besar. Pengaruh panjang serat terhadap kekuatan lentur tidak memberikan pengaruh yang signifikan.
Perancangan dan Pembuatan Mesin Grinda Mantis Chip (GMC) Untuk Mengoptimalkan Proses Pengrindaan Chip Di PT. Promanufacture Indonesia
Authors: Nugroho Oktavianus Ardhian , Antonio Kevin Yonathan , Purwanto Guruh 
Published: February 2025

PT. Promanufacture Indonesia bergerak di bidang bioteknologi yang memproduksi alat laboratorium. Salah satu perangkat yang sedang dikembangkan adalah mesin Mantis-Tempest Chip (MTC). Pada alat ini pengembangan, dan modifikasi dilakukan pada desain dari chip. Chip yang dikembangkan merupakan instrument laboratorium yang digunakan untuk dispensing reagan dengan sistem mikrofluida dan dapat menghasilkan berat dengan volume yang presisi dari berbagai jenis sampel dengan nilai viskositas tertentu. Dalam proses manufaktur chip ada 1 proses yang dianggap rumit, proses ini adalah proses lasering yang digunakan untuk memberikan penomoran pada chip. Untuk melakukan proses ini sebelumnya perlu dilakukan proses penghalusan permukaan pada bagian yang akan dilasering. Selama ini proses ini masih dilakukan secara manual dengan cara mengamplas satu persatu chip. Oleh sebab itu waktu yang dibutuhkan untuk proses lasering menjadi lama. Tujuan dari penelitian ini adalah membuat sebuah mesin grinding yang dikhususkan untuk proses pengrindaan chip, dengan posisi yang bisa diatur ketinggian mata grindanya, mesin ini nantinya akan digunakan oleh divisi produksi di PT. Promanufacture dalam upaya mempercepat proses pengrindaaan dan meningkatkan kecepatan dan jumlah chip yang bisa di lasering penomoran. Hasil dari penelitian ini didapatkan sebuah mesin Grinding Mantis Chip (GMC) dengan dimensi 170 x 110 x 50 mm, dilengkapi posisi grinda yang bisa diadjustable pada ketinggian 45mm sampai 55mm, dan bisa mengerinda permukaan chip secara merata, dan konsisten. Selain itu hasil mesin GMC yang sudah dibuat dan diuji ini dapat melakukan proses pengrindaan 6 chip bersamaan dalam waktu 32 detik sehingga mengoptimalkan proses yang sebelumnya ada.
Analisisi Kekakuan Pelat Baja Galvanil Ketebalan 0,6 MM Akibat Pembentukan Dengan Metode Bead Rolled
Authors: M Fadillah Febian , Erwanto Erwanto 
Published: February 2025

Abstrak

Proses pembentukan pelat secara dingin pada pelat tipis banyak digunakan dan diperlukan pada industri manufaktur, contohnya pada industri otomotif. Salah satu proses pembentukan profil pelat secara dingin dengan cara proses roll pelat atau sering disebut " Bead Roll". Proses bead roll banyak umum digunakan karena prosesnya murah, tapi mampu memperbaiki/ menambah kemampuan menahan getaran (vibrasi) yang baik, untuk mengetahui seberapa kemampuan menahan getaran (vibrasi) tersebut maka dirancang sebuah mesin "Bead Roller". Mesin "Bead Roller" berfungsi untuk membuat lekukan atau profil pada lembaran pelat. Mesin ini memiliki sepasang roll silinder yang berfungsi untuk membuat lekukan atau profil pelat, yang pada akhirnya bertujuan untuk mengetahui profil yang terbaik yang mampu meredam getaran pada pelat galvanil . Hasil penelitian ini diharapkan dapat memperluas pengetahuan tentang pelat yang digunakan sebagai inovasi bentuk baru dan menjadi referensi penelitian dan pengembangan di masa depan.
Kata kunci : Industri, Kekakuan pada pelat, Bead Roll, Frekuensi alami,Galvanil.
Penggunaan Fly Ash sebagai Material Bata Beton untuk Meningkatkan Daya Peredaman Panas pada Ruangan
Authors: Napitupulu Robert , Chardova Andreas , Kurniawan Zaldy 
Published: February 2025

Pemanfataan fly ash sebagai bahan tambah bata beton memberikan dampak positif terhadap lingkungan, selain mengurangi pencemaran lingkungan. Fly ash memiliki kandungan silikat yang kemiripan seperti semen, penambahan fly ash pada campuran bata beton bisa menjadi bahan tambah mineral yang baik untuk bata beton karena fly ash tersebut mengandung silika yang bersifat mengikat. Penelitian ini bertujuan untuk mengetahui pengaruh limbah fly ash sebagai bahan tambah terhadap peredaman panas serta mengetahui nilai komposisi yang tertinggi dan terendah untuk penambahan limbah fly ash terhadap bata beton agar dapat meredam panas. Metode yang digunakan dalam penelitian ini adalah metode full faktorial dengan variabel proses fly ash : pasir 10% : 60%, 20% : 50%, 30% : 40% dan lama pengeringan 3 dan 5 hari, dan dilakukan uji peredaman panas sebagai respon yang diamati dengan jumlah 6 spesimen dan 3 kali replikasi pada setiap spesimen. Berdasarkan hasil penelitian yang diperoleh menunjukkan bahwa spesimen dengan fly ash : pasir 30% : 40% dengan waktu pengeringan 5 hari mendapatkan nilai tertinggi sebesar 6,6oC. sedangkan fly ash : pasir 10% : 60% dengan waktu pengeringan 3 hari mendapatkan nilai terendah sebesar 4oC.
Mean Platelet Volume as Potential Predictor of Intradialytic Hypertension
Authors: Soelistyoningsih Dwi , Wira Daramatasia , Qodir Abdul , Rifa'i Achmad 
Published: February 2025

Abnormalities in platelets can lead to severe consequences renal and systemic blood flow. The aim of this study is to determine the predictive ability of platelet indices (mean platelet volume, platelet-lymphocyte ratio, and platelet count) in relation to changes in blood pressure before and immediately after hemodialysis. This study included 98 patients undergoing hemodialysis at the RSU UMM Malang, aged ≥18 years, hemodialysis duration > 1 month, and signing informed consent. The predictor variable were MPV, PLR, and platelet count and the outcome was the incidence of IDHT. There was a significant difference in the blood pressure of patients undergoing hemodialysis before compared to immediately after hemodialysis, for both systolic and diastolic blood pressure (p < 0.001). To assess the sensitivity and specificity of the accuracy of the platelet count, MPV, and PLR markers in predicting IDHT, ROC curve was created based on the difference in systolic blood pressure before-after hemodialysis. From the receiver operating characteristic (ROC) curve, it was found that the MPV value was the highest above the diagonal line compared to PLR and platelet count with an MPV cut-off value was 9.15. This indicates that MPV is the best predictive marker compared to the other models.
Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments
Authors: Li Yunhao , Xuan Fengqi , Zhang Daoyang , Sun Mingyu , Zhang Ping , Zhang Qi , Zhang Jie , Han Yaling , Wang Zulu , Liang Ming 
Published: February 2025

AimsThe study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.MethodsPotatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.Results and conclusionThe key ablation parameters have varying degrees of influence on lesion depths, following the order of PW&gt;V; V&gt;P; PW&gt;P; N&gt;P. Lesion depths increased with higher values of V and P. However, when the total number of pulses reached 9,600, there was no significant increase in injury depth.
Atherogenic index of plasma and cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stage 1 to 3: a longitudinal study
Authors: Zhang Yu , Song Yue , Lu Yinfei , Liu Tao , Yin Ping 
Published: February 2025

BackgroundCardiovascular disease (CVD) remains a major contributor to the global disease burden. Previous studies have established a link between the atherogenic index of plasma (AIP) and CVD. However, it remains unclear whether cumulative AIP and AIP control influence the future incidence of CVD in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome. This study aims to explore the association between cumulative AIP, AIP control levels, and the risk of CVD in individuals with CKM syndrome from stages 1 to 3.MethodsParticipants with CKM syndrome were drawn from the China Health and Retirement Longitudinal Study (CHARLS). Cumulative AIP was calculated using triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C), while AIP control levels were categorized into four groups via k-means clustering. CVD was defined by self-reported heart disease or stroke. Multivariable logistic regression and restricted cubic spline analysis were employed to examine the association between AIP and incident CVD in individuals with CKM syndrome.ResultsA total of 793 participants (18.84%) developed CVD. After adjusting for confounders, cumulative AIP were associated with the developing CVD (OR=1.139, 95% CI: 1.017-1.275, P=0.0245). Compared to group 1 (best AIP control), the OR (95% CI) for incident CVD were 1.278 (0.959-1.702) for group 2, 1.329 (1.076-1.641) for group 3, and 1.195 (0.974-1.465) for group 4. Restricted cubic spline regression indicated the relationship between cumulative AIP and CVD risk is linear (P for nonlinear = 0.3377).ConclusionsIn middle-aged and elderly individuals with CKM syndrome, higher cumulative AIP and poorer AIP control were associated with an elevated incidence of CVD. These findings suggest that enhanced assessment of the AIP index could inform targeted prevention strategies for CVD in the context of CKM syndrome.
Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study
Authors: Zhang Yue-Yang , Yang Xiao-Yu , Wan Qin 
Published: February 2025

BackgroundThe Atherogenic Index of Plasma (AIP) was originally developed primarily as a marker for assessing atherosclerosis. Consequently, this study investigates the potential association between AIP and type 2 diabetic complications through a cross-sectional design.MethodsThe National Metabolic Management Center(MMC) serves as a comprehensive platform dedicated to the establishment of standardized protocols for the diagnosis, treatment, and long-term follow-up of metabolic diseases. Following the relevant inclusion and exclusion criteria, a total of 3,094 patients were enrolled for subsequent analysis. In this study, logistic regression, restricted cubic splines, and subgroup analyses were employed to evaluate the association between the AIP and four major complications of type 2 diabetes, namely, type 2 diabetes with carotid atherosclerosis (DA), diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN).ResultsThe logistic regression results demonstrate that in the fully adjusted model, each SD increase in AIP correlates with an elevated risk of type 2 diabetic kidney disease (DKD), with the risk of kidney damage intensifying alongside higher AIP groupings. The RCS analysis and subgroup analyses similarly revealed a dose-response relationship between AIP levels and the risk of DKD. Furthermore, the AIP was not found to be statistically significantly associated with DA, DR,and DPN.ConclusionsThe AIP may serve as a valuable predictive indicator for evaluating kidney damage in patients with type 2 diabetes, and regular screening of AIP in this population could provide significant benefits in the prevention of DKD.
Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia
Authors: Liu Guihong , Sun Liangliang , Lv Peng , Qiao Rong , Wang Lihang , Jin Arong 
Published: February 2025

ObjectiveLong non-coding RNA (lncRNA) is aberrantly expressed in a variety of tumor diseases. To date, its specific role in acute myeloid leukemia (AML) has not been fully elucidated. This study aims to evaluate the association between aberrant lncRNA expression and poor prognosis in AML patients, and to systematically assess the relationship between aberrant lncRNA expression and AML prognosis.MethodsWe conducted a comprehensive literature search in PubMed, Embase, Cochrane Library, CNKI (China National Knowledge Infrastructure), WanFang (China Wanfang Database), VIP (China VIP Database), and Sinomed (China Biomedical Literature Database) to identify relevant Chinese and English articles. The search period covered from the inception of these databases to 4 August 2024. Articles were screened according to predefined inclusion and exclusion criteria, and meta-analysis was performed using Stata.ResultsA total of 25 articles were included in the analysis. Aberrant lncRNA expression was significantly associated with reduced overall survival (univariate HR = 2.46, 95%CI 2.11–2.88, P &lt; 0.001; multivariate HR = 2.46, 95%CI 2.11–2.88, P &lt; 0.001), event-free survival (HR = 1.51, 95%CI 1.19–1.90, P = 0.001), recurrence-free survival (HR = 2.82, 95%CI 2.03–3.91, P &lt; 0.001), and disease-free survival (HR = 2.390, 95%CI 1.037–5.507, P = 0.041). These findings were statistically significant. The 25 articles collectively identified 22 lncRNAs whose aberrant expression was associated with AML prognosis. Notably, multiple studies highlighted the aberrant expression of lncRNA CRNDE, ZEB2-AS1, and TUG1 as being particularly relevant to AML prognosis. Our meta-analysis revealed that high expression of lncRNA CRNDE and TUG1 was associated with reduced overall survival, while high expression of lncRNA ZEB2-AS1 was linked to decreased disease-free survival, both with statistically significant differences.ConclusionThe expression levels of lncRNAs are closely associated with the prognosis of AML patients and may serve as important indicators for monitoring prognosis in the future. However, further high-quality studies are needed to validate these findings.
Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers
Authors: Li Ruohua , Zhou Cuixia , Ye Kejun , Chen Haihui , Peng Mengjia 
Published: February 2025

BackgroundPreeclampsia is a complex pregnancy condition marked by hypertension and organ dysfunction, posing significant risks to maternal and fetal health. This study investigates the role of energy metabolism-associated genes in preeclampsia development and identifies potential early diagnostic biomarkers.MethodsPreeclampsia datasets from Gene Expression Omnibus were analyzed for batch correction, normalization, and differential expression. Enrichment analyses using gene ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment were performed. Protein-protein interaction networks were constructed to identify key genes, and regulatory networks involving transcription factors, miRNAs, and RNA-binding proteins were established. Differential expression was validated with receiver operating characteristic curve analyses, and immune infiltration was assessed.ResultsSix energy metabolism-related genes were identified. Enrichment analyses revealed their involvement in glycolysis, gluconeogenesis, lipid transport, bone remodeling, and glucagon secretion. Key differentially expressed genes included CRH(Corticotropin-Releasing Hormone), LEP(Leptin), PDK4(Pyruvate Dehydrogenase Kinase Isozyme 4), SPP1(Secreted Phosphoprotein 1), and SST(Somatostatin). PDK4 exhibited moderate accuracy in receiver operating characteristic analysis. Immune infiltration analysis indicated significant differences between preeclampsia and control samples. qRT-PCR confirmed LEP and CRH increased, while SPP1 expression in preeclampsia samples.ConclusionDysregulated energy metabolism-related genes may contribute to preeclampsia through metabolic and immune changes. Identifying these genes aids in understanding preeclampsia’s molecular basis and early diagnosis. Future studies should validate these markers in larger cohorts and explore targeted treatments.
Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity
Authors: Rakib Ahmed , Mandal Mousumi , Al Mamun Md Abdullah , Kiran Sonia , Yasmen Nelufar , Li Lexiao , Collier Daniel M. , Jiang Jianxiong , Park Frank , Singh Udai P. 
Published: February 2025

BackgroundObesity is associated with dysregulated metabolism and low-grade chronic inflammation in adipose tissue (AT). Immune cells, including macrophages, T cells, and neutrophils, infiltrate the AT and secrete proinflammatory cytokines to exacerbate the AT inflammation. RNA-Seq analysis of AT immune cells isolated from mice fed a high-fat diet (HFD) versus normal fat diet (ND) identified a panel of genes that were markedly downregulated, including sialic acid-binding Ig-like lectin E (siglec-E), in HFD compared to ND mice.MethodsA series of experiments in wild-type (WT) and siglec-E knockout (siglec-E KO) mice was designed to investigate the effect of HFD on the functional role of siglec-E in the regulation of AT inflammation and adipogenesis. We analyzed the changes in immune phenotypes, inflammatory response, adipogenesis, and levels of cytokines and chemokines after HFD and ND feeding.ResultsHFD consumption significantly increased the body weight and blood glucose levels in siglec-E KO mice relative to those of WT mice. This was associated with an increased infiltration of macrophages, CXCR3 expressing CD8 T cells, and monocytic myeloid-derived suppressor cells (M-MDSCs) with a concomitant decrease in numbers of dendritic cells (DCs), in the AT of siglec-E KO fed HFD versus the WT HFD counterparts. The HFD-fed siglec-E KO mice also exhibited elevated expression of intracellular Akt and TNF receptor-associated factor 3 (TRAF3) signaling, inducing C/EBPα, FASN, PPARγ, and resistin in suprascapular AT compared to WT HFD-fed mice. Taken together, these results suggest that a genetic deficiency of siglec-E plays a key role in inducing AT inflammation by differentially altering M-MDSCs and CD8+CXCR3+ T cell function and adipogenesis by TRAF3 and Akt signaling in AT.ConclusionOur findings strongly suggest that modulation of siglec-E pathways might have a protective effect at least in part against AT inflammation and metabolic disorders.
Discovery and in vitro characterization of a human anti-CD36 scFv
Authors: Mata-Cruz Cecilia , Guerrero-Rodríguez Sandra L. , Gómez-Castellano Keyla , Carballo-Uicab Gregorio , Almagro Juan Carlos , Pérez-Tapia S. Mayra , Velasco-Velázquez Marco A. 
Published: February 2025

IntroductionCD36 is a membrane receptor that participates in the cellular uptake of fatty acids and lipid metabolism. CD36 overexpression favors progression of different pathologies, such as atherosclerosis and cancer. Thus, CD36 targeting has medicinal relevance. Herein, we aimed to identify human anti-CD36 single-chain variable fragment (scFv) with therapeutic potential.MethodsThe semisynthetic ALTHEA Gold Plus Libraries™ were panned using recombinant human CD36. Clone selection was performed by ELISA. Analysis of scFv binding and blocking function was evaluated by flow cytometry in macrophage-like THP-1 cells and hepatocellular carcinoma HepG2 cells. The phenotypic changes induced by CD36 ligands were assessed in vitro by: i) oil red staining, ii) tumorsphere assays, and iii) RT-qPCR.ResultsWe identified an anti-CD36 scFv, called D11, that competes with a commercial anti-CD36 antibody with proven efficacy in disease models. D11 binds to CD36 expressed in the membrane of the cellular models employed and reduces the uptake of CD36 ligands. In macrophage-like THP-1 cells, D11 impaired the acquisition of foam cell phenotype induced by oxLDL, decreasing lipid droplet content and the expression of lipid metabolism genes. Treatment of HepG2 cells with D11 reduced lipid accumulation and the enhanced clonogenicity stimulated by palmitate.ConclusionWe discovered a new fully human scFv that is an effective blocker of CD36. Since D11 reduces the acquisition of pathogenic features induced by CD36 ligands, it could support the generation of therapeutic proteins targeting CD36.
Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China
Authors: Liu Zhongzhong , Zhang Dandan , Zeng Lingxia , Guo Weiyan , Lu Qingli , Lei Zhen , Hao Yunlong , Liu Pei , Liu Tong , Peng Linna , Chang Qiaoqiao , Zhang Mi , Lin Xuemei , Wang Fang , Wu Songdi 
Published: February 2025

BackgroundThe relationship between abnormal renal function and serum uric acid levels in patients with acute ischemic stroke (AIS) remains insufficiently explored. Although uric acid is associated with cardiovascular and cerebrovascular risk, the specific link between normalized serum uric acid (SUA/SCr) and stroke recurrence in patients with impaired renal function has not been well studied. This study aims to fill this gap by investigating the association between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function.MethodsThis study utilized the ratio of serum uric acid (SUA) to serum creatinine (SCr) to represent SUA levels normalized for renal function. Abnormal Renal function was defined by the estimated glomerular filtration rate (eGFR) &lt; 90 mL/min/1.73 m2. Multivariable Cox regression, curve fitting, and stratified analyses were employed to assess the relationship between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function, considering SUA/SCr as both a continuous variable and in quartiles (Q1–Q4).ResultsOf 1,932 enrolled patients (65.3% male; mean age 66.7 ± 11.3 years), each unit of increase in SUA/SCr was associated with a 17% decrease in 1-year stroke recurrence (HR = 0.83, 95% CI 0.73 to 0.96, P = 0.009). Compared to Q1, the Q2 and Q4 groups showed significantly reduced risk in 1-year stroke recurrence (Q2: HR = 0.46, 95% CI 0.27 to 0.79, P = 0.005; Q4: HR = 0.47, 95% CI 0.27 to 0.81, P = 0.007), with a significant trend across all quartiles (P = 0.01 for trend tests). Curve fitting revealed a negative but non-linear correlation. Subgroup analyses showed that in patients with eGFR &lt; 60 ml/min/1.73 m2, Q4 had significantly lower 1-year stroke recurrence risk than Q1 (HR = 0.19, 95% CI 0.04 to 0.86, P = 0.031).ConclusionLow SUA/SCr independently predicts 1-year stroke recurrence in patients with AIS and abnormal renal function, particularly in those with eGFR &lt; 60 mL/min/1.73 m2.