bluuebunny/crossref_metadata_2025_split huggingface dataset:
“The Spanish Cathedral”, a Prototype of Mobile Application for the Access to the Religious Cultural Heritage of Gothic Hispanic Cathedrals
Authors: Barbosa Jennifer Carolina Cruz , Zymla Herbert González 
Published: January 2024

After an in-depth examination of the communication strategies, digital offerings, and audio guides currently employed by various Spanish cathedrals constructed during the 12th and 15th centuries, it was detected that there was a need to gradually build and improve an integral and unified tool that serves as a reference for the learning of the artistic elements that characterize the mentioned constructions. This will contribute to both the promotion of the cathedral —understood as an ensemble— and its communication with the public.
This article introduces the conceptualization and design of the mobile application “La Catedral Hispana”, a high-fidelity prototype that seeks to promote Spanish cathedrals with Gothic elements in their construction. This prototype encompasses two areas of study for its task: the research of Gothic architecture in cathedrals and the principles of user experience (interaction design, information architecture, and interface development), for the correct development of the sample, using the Figma software for its design and implementation.
The objectives lay not only in providing a tool that facilitates access and shares academic information, but also in establishing relationships among the diverse Spanish cathedrals by means of their common features. The Spanish Cathedral is a proposal for promoting the democratization of cultural information, the learning of the value of heritage, and the development of a new solid and accessible communication channel that enables the target audience to both value and recognize one of the most important types of constructions as a part of Spanish identity.
Mitochondrial DNA Haplogroups and SNPs: Risk Factors in Multiple Cancers Based on a Cross-Tumor Analysis in Chinese Population
Authors: Chen Dongbo , Yan Zeyu , Yuan Qing , Xie Fanfan , Liu Yang , Feng Zehui , Wang Zhenni , Zhou Feng , Xing Jinliang , Zhang Zhaohui , Wang Fuli , Guo Xu 
Published: January 2024

Abstract

Background:
Mitochondrial DNA's (mtDNA) haplogroups and SNPs were associated with the risk of different cancer. However, there is no evidence that the same haplogroup or mitochondrial SNP (mtSNP) exhibits the pleiotropic effect on multiple cancers.

Methods:
We recruited 2,489 participants, including patients with colorectal, hepatocellular, lung, ovarian, bladder, breast, pancreatic, and renal cell carcinoma. In addition, 715 healthy individuals from Northern China served as controls. Next, cross-tumor analysis was performed to determine whether mtDNA variation is associated with multiple cancers.

Results:
Our results revealed a significant decrease in the occurrence risk of multiple cancers among individuals belonging to haplogroup A [OR = 0.553, 95% confidence interval (CI) = 0.375–0.815, P = 0.003]. Furthermore, we identified 11 mtSNPs associated with multiple cancers and divided the population into high-risk and low-risk groups. Low-risk groups showed a significantly reduced risk of occurrence compared with high-risk groups (OR = 0.614, 95% CI = 0.507–0.744, P &lt; 0.001). Furthermore, using interaction analysis, we identified a special group of individuals belonging to haplogroup A/M7 and the low-risk population, who exhibit a lower risk of multiple cancers compared with other populations (OR = 0.195, 95% CI = 0.106–0.359, P &lt; 0.001). Finally, gene set enrichment analysis confirmed that haplogroup A/M7 patients had lower expression levels of cancer-related pathway genes compared with haplogroup D patients.

Conclusions:
We found that specific mtDNA haplogroups and mtSNPs may play a role in predicting multiple cancer predisposition in Chinese populations.

Impact:
This may provide a potential tool for early screening in clinical settings for individuals in the Chinese population.
Mobilizing China and the Global Community to Confront the Treatment Desert for Pediatric Solid Tumors
Authors: Wang Shuhang , Jiang Yale , Zheng Rongshou , Yu Yue , Wei Wenqiang , Li Ning 
Published: January 2024

Summary:
Pediatric solid tumors are distinct clinical entities that impose heavy socioeconomic burden and while their incidence has increased in recent years, treatment options are often limited, with only 27 drugs approved for pediatric solid tumors in the United States, and fewer still, 13, in China. The scale of the unmet medical need is immense and new efforts are urgently needed to develop efficient therapeutics and improve these children's lives.
Measuring Progress in Precision Oncology
Authors: Horak Peter , Fröhling Stefan 
Published: January 2024

Summary:
In this issue of Cancer Discovery, Suehnholz and colleagues describe their efforts to quantify the gradual yet steady progress of precision oncology by surveying the regulatory approvals of targeted cancer therapies, and thus the actionability of corresponding molecular alterations in clinical practice, over more than 20 years. Their work also suggests a relationship between the discovery of candidate therapeutic targets through comprehensive tumor profiling and molecularly guided cancer drug development.
See related article by Suehnholz et al., p. 49 (5).
Is It Time to Incorporate Liquid Biopsy into High-Risk Cancer Surveillance Protocols in Li–Fraumeni Syndrome?
Authors: Latham Alicia , MacFarland Suzanne P. , Walsh Michael F. , Maxwell Kara N. , Stadler Zsofia K. 
Published: January 2024

Summary:
In the first prospective study evaluating circulating tumor DNA (ctDNA) for early cancer detection, Wong, Luo, and colleauges demonstrate the feasibility of liquid biopsy as an augmentation to current surveillance protocols for patients with Li–Fraumeni syndrome, an inherited cancer predisposition associated with high cancer risk in both pediatric and adult populations. Though additional clinical validation in larger cohorts is needed, this research highlights that a multimodal approach is likely necessary to improve the sensitivity of liquid biopsy assays for early cancer detection.
See related article by Wong, Lou et al., p. 104 (9).
Democracia e opinião pública em Platão
Authors: Comparini Julio de Souza , Nunes Silvio Gabriel Serrano , Tomelin Georghio Alessandro 
Published: January 2024

O presente estudo busca examinar alguns dos debates socrático-platônicos sobre a opinião pública diante da busca da verdade, e seu impacto político, particularmente para a democracia, que depende da noção de liberdade. Depois de se entender o avanço da visão de Platão sobre o problema da opinião e a impossibilidade de seu sobrepujamento geral, discute-se a visão do autor sobre o regime que dá poder ao demos e, ao final, que tipo de aprendizado se pode daí extrair para as democracias contemporâneas.
Genetic Evidence for the Causal Association of Circulating Cytokines and Growth Factors With Coronary Artery Disease
Authors: Li Yuwei , Liu Bin , Chen Ying , Liu Ziying , Ye Ding , Mao Yingying , Sun Xiaohui 
Published: January 2024

Background
Observational studies have suggested the potential role of inflammatory factors in the risk of coronary artery disease (CAD). We aimed to perform 2‐sample Mendelian randomization (MR) analyses to assess the causal association between circulating cytokines/growth factors and CAD.

Methods and Results

The instrumental variables for 28 circulating cytokines and growth factors were identified from a genome‐wide association study of 8293 European participants. Summary‐level data on CAD were derived from a large genome‐wide association study (71 602 cases and 260 875 controls). We used the inverse‐variance‐weighted and Wald ratio methods as our main MR methods. The weighted median, simple median, maximum likelihood, MR pleiotropy residual sum and outlier, and MR‐Egger methods were performed as sensitivity analyses. Genetic colocalization analyses were conducted to validate the robustness of our MR findings. We found that genetically predicted circulating levels of macrophage migration inhibitory factor were associated with an increased risk of CAD at the Bonferroni‐adjusted level of significance (
P
<1.79×10
−3
). The odds ratio was 1.20 (95% CI, 1.08–1.33;
P
=6.83×10
−4
) per 1‐SD increase in macrophage migration inhibitory factor. Colocalization analyses supported our MR findings. Additionally, we found suggestive evidence between the genetic effects of stem cell growth factor‐β and the risk of CAD (odds ratio, 0.95 [95% CI, 0.91–0.98];
P
=0.007).

Conclusions
Our findings suggested a risk‐increasing effect of macrophage migration inhibitory factor level on the development of CAD. The roles of these inflammatory factors for CAD warrant further investigation.
Sensitivity of stubby root nematodes (Trichodorus and Paratrichodorus spp.) to isothiocyanates associated with Brassicaceae in an in vitro assay
Authors: Mwangi Nyambura G. , Stevens Mark , Wright Alistair J.D. , Edwards Simon G. , Hare Martin C. , Back Matthew A. 
Published: January 2024

Summary
Brassicas contain glucosinolates (GSLs), which are converted into different isothiocyanates (ITCs) that possess biocidal activity. These different ITCs result in a range of toxicities to various target species. Laboratory assays were conducted to evaluate the sensitivity of stubby root nematodes (SRN), Trichodorus and Paratrichodorus spp., to three pure, commercially available ITCs, i.e., 2-phenylethyl (PEITC), allyl (AITC) and sulforaphane (SITC) at different concentrations (1.625, 3.125, 6.25, 12.5, 25 and 50 μg ml−1). The effect on nematode mobility was assessed after 24, 48 and 72 h. Mortality of SRN was assessed after 48 h incubation of the nematodes in distilled water post ITC treatment. Mortality for all ITCs at all tested concentrations was significantly higher than the controls, distilled water and 1% DMSO. Concentration and type of ITC had a significant effect on SRN mobility and mortality, whilst increase in exposure time did not significantly increase the immobility of SRN. The average 24 h ED50 (dose that resulted in 50% immobility) for SRN were 7, 5 and 44 μg ml−1, and the average LD50 (dose that resulted in 50% mortality) after 48 h recovery in distilled water was 7, 11 and 24.3 μg ml−1 for PEITC, AITC and SITC, respectively. SITC was significantly less potent compared to PEITC and AITC, which had LD50 values that were four times and two times lower, respectively. These results indicate the potential use of brassica associated with the tested ITC in the process of biofumigation for SRN suppression.
The Utility of ACR TI-RADS in Predicting False-Negative Fine Needle Aspiration for Thyroid Cancer
Authors: Dimaano Katrina L. , Dib Valerie A. , Parnall Taylor , Covington Audrey , Kaji Amy H. , Choi Patrick , Chen Kathryn T. 
Published: January 2024

Background Thyroid nodule fine needle aspiration (FNA) biopsies are associated with a low false-negative rate. There is limited data regarding the predictive value of American College of Radiology Thyroid Imaging Reporting and Data System for false-negative FNA. Methods This single-center retrospective study evaluated 119 patients who underwent thyroidectomy. The association of TR category, along with other clinical variables, with false-negative FNA was evaluated. Results The overall false-negative rate of FNA was 10.8% (n = 9). False-negative FNAs were associated with younger age (mean 42 years vs 50.6 years, P = .04), larger nodule size (mean 4.4 cm vs 3.2 cm, P = .03), and a lower TR category (median 3 v 4, P = .01). Discussion Lower TR category, younger age, and larger nodule size were associated with false-negative FNA of thyroid nodules. These findings should be taken into context when counseling patients with thyroid nodules who have a benign FNA.
Practices of Adult Spine Immobilization During Trauma Resuscitation: Proposal for Improved Guidelines
Authors: Breeding Tessa , Nasef Hazem , Amin Quratulain , Wright D-dre , Zito Tracy , Elkbuli Adel 
Published: January 2024

Introduction This narrative review aims to evaluate the impact of current spinal immobilization practices on clinical outcomes in adult trauma patients with suspected or confirmed spinal injury to direct the creation of improved practice management guidelines. Methods PubMed, ProQuest, Embase, Google Scholar, and Cochrane were searched for studies that evaluated the impact of spine immobilization practices during resuscitation in adult trauma patients and reported associated clinical outcomes. Outcomes included neurological deficits, in-hospital mortality, hospital length of stay (HLOS), ICU length of stay (ICU-LOS), discharge disposition, long-term functional status (modified Rankin scale), vascular injury rate, and respiratory injury rate. Results Nine studies were included in this review, divided into two groups based on patient immobilization status. Patients compared with and without cervical immobilization had higher mortality, longer ICU-LOS, and a higher incidence of neurological deficits if immobilized. Immobilization only was associated with a higher incidence of indirect neurological injury and poor functional outcomes. Conclusion Spinal immobilization during resuscitation in adult trauma patients is associated with a higher risk of neurological injury, in-hospital mortality, and longer ICU-LOS. Further research is needed to provide strong evidence for spinal immobilization guidelines and identify the optimal method and timing for immobilization practices in trauma patients.
Histograms of computed tomography values in differential diagnosis of benign and malignant osteogenic lesions
Authors: Wang Ruiqing , Zhou Ruizhi , Sun Shiqing , Yang Zhitao , Chen Haisong 
Published: January 2024

Background The use of histogram analysis of computed tomography (CT) values is a potential method for differentiating between benign osteoblastic lesions (BOLs) and malignant osteoblastic lesions (MOLs). Purpose To explore the diagnostic efficacy of histogram analysis in accurately distinguishing between BOLs and MOLs based on CT values. Material and Methods A total of 25 BOLs and 25 MOLs, which were confirmed through pathology or imaging follow-up, were included in this study. FireVoxel software was used to process the lesions and obtain various histogram parameters, including mean value, standard deviation, variance, coefficient of variation, skewness, kurtosis, entropy value, and percentiles ranging from 1st to 99th. Statistical tests, such as two independent-sample t-tests and the Mann–Whitney U test with Bonferroni correction, were employed to compare the differences in histogram parameters between BOLs and MOLs. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of each parameter. Results Significant differences were observed in several histogram parameters between BOLs and MOLs, including the mean value, coefficient of variation, skewness, and various percentiles. Notably, the 25th percentile demonstrated the highest diagnostic efficacy, as indicated by the largest area under the curve in the ROC curve analysis. Conclusion Histogram analysis of CT values provides valuable diagnostic information for accurately differentiating between BOLs and MOLs. Among the different parameters, the 25th percentile parameter proves to be the most effective in this discrimination process.
Pharmacologic characterization of atogepant: A potent and selective calcitonin gene–related peptide receptor antagonist
Authors: Moore Eric , Bell Ian M , Fraley Mark E , Burgey Christopher S , White Rebecca B , Li Chi-Chung , Regan Christopher P , Danziger Andrew , McGaraughty Steve P , Naseri Kouzehgarani Ghazal , Salvatore Christopher , Banerjee Pradeep 
Published: January 2024

Background The trigeminal sensory neuropeptide calcitonin gene–related peptide (CGRP) is identified as an essential element in migraine pathogenesis. Methods In vitro and in vivo studies evaluated pharmacologic properties of the CGRP receptor antagonist atogepant. Radioligand binding using 125I-CGRP and cyclic adenosine monophosphate (cAMP) accumulation assays were conducted in human embryonic kidney 293 cells to assess affinity, functional potency and selectivity. Atogepant in vivo potency was assessed in the rat nitroglycerine model of facial allodynia and primate capsaicin-induced dermal vasodilation (CIDV) pharmacodynamic model. Cerebrospinal fluid/brain penetration and behavioral effects of chronic dosing and upon withdrawal were evaluated in rats. Results Atogepant exhibited high human CGRP receptor-binding affinity and potently inhibited human α-CGRP-stimulated cAMP responses. Atogepant exhibited significant affinity for the amylin1 receptor but lacked appreciable affinities for adrenomedullin, calcitonin and other known neurotransmitter receptor targets. Atogepant dose-dependently inhibited facial allodynia in the rat nitroglycerine model and produced significant CIDV inhibition in primates. Brain penetration and behavioral/physical signs during chronic dosing and abrupt withdrawal were minimal in rats. Conclusions Atogepant is a competitive antagonist with high affinity, potency and selectivity for the human CGRP receptor. Atogepant demonstrated a potent, concentration-dependent exposure/efficacy relationship between atogepant plasma concentrations and inhibition of CGRP-dependent effects.
Self-Efficacy in Patients With Hypertension and Their Perceived Usage of Patient Portals
Authors: Lim Weai Ling , Koh Yi Ling Eileen , Tan Zhi En , Tan Yu Quan , Tan Ngiap Chuan 
Published: January 2024

Introduction: Self-efficacy in individuals optimizes their hypertension management. Electronic patient portals are being increasingly used to support chronic disease management, as they raise the health literacy of patients and enable them in self-management. However, the association between the use of patient portals and self-efficacy in hypertension management remains unclear. The study aimed to determine the association between self-efficacy among patients with hypertension who are managed in primary care and their demographic characteristics and usage patterns of patient portals. Method: A cross-sectional survey was conducted at a public primary care clinic in urban Singapore. Multi-ethnic adult patients with hypertension were invited to participate in a self-administered electronic questionnaire. Chi-square test was performed for bivariate analysis; adjusted logistic regression models were used for factors with P value <.1. Results: A total of 310 patients (66.8% Chinese, 55.5% males, mean age of 63.1 years) completed the survey. Patient portal users had higher self-efficacy scores than non-users (mean score=63 vs 60, maximum = 80, P = .011). The factors associated with increased patient portal access included younger age <65 years (absolute odds ratio [AOR] = 2.634, 95%CI = 1.432-4.847; P = .002), monthly income >$5000 (AOR = 2.324, 95%CI = 1.104-4.892; P = .026), and post-secondary education level (AOR = 3.128, 95%CI = 1.675-5.839; P < .001). Most patients (93.1%) used the portal to check medical appointments but only1.3% of them used it to record home blood pressure measurements (HBPM). Conclusions: Patient portal usage was associated with higher self-efficacy scores in patients with hypertension. These users were younger, more educated, and earned more than the non-users, but only 1.3% of them used it for HBPM documentation.
A Micro-Level Evidence of how Investor and Manager Herding Behavior Influence the Firm Financial Performance
Authors: Shah Sayyed Sadaqat Hussain , Khan Muhammad Asif , Ahmed Masood , Meyer Daniel F. , Oláh Judit 
Published: January 2024

Using the investor-herding index (IHRB) and manager-herding index (MHRB), the emergence of investors’ and managers’ herding behavior at the corporate-level and its potential impact on firm financial performance (FFP) is analyzed in the entire study. The study utilizes the micro-level data of 296 listed firms of Pakistan stock exchange (PSX) from 2013 to 2017. Empirical findings show that the investors’ and managers’ herding significantly affect FFP. The results are robust under alternative measurements of FFP. This study has a unique contribution to the literature on behavioral finance by addressing the astonishingly overlooked phenomena of firm-level biases and their potential impact on FFP. For prospective investor’s decision, the findings are significant in such way that the market index is irrelevant than the firm-level financial evidence. Explicitly, the study concludes that positive herding behavior is elucidated by the bullish trend and inverse herding behavior of investors with respective to firm value leads toward bearish trend of stock market index. The likelihood of market crash may become more stringent in circumstances once managers and investors interactively exhibit negative herding behavior. Thus, the study offers useful policy and strategy implications for the associated stakeholders to the device the policies accordingly. JEL Code: D9, D21, D91, G11.
Posterior Cruciate Ligament Reconstruction With Quadriceps Tendon Autograft and Concomitant Meniscal Ramp Repair
Authors: Glover Mark A. , Mason Thomas W. , Albertson Benjamin S. , Trasolini Nicholas A. , Waterman Brian R. 
Published: January 2024

Background: Quadriceps autograft, though well established for anterior cruciate ligament reconstruction, is underutilized in posterior cruciate ligament (PCL) reconstruction largely due to slow adoption. All-inside meniscal ramp repair and quadriceps tendon autograft PCL reconstruction have been described in isolation, but not concomitantly in a video journal. Indications: PCL reconstruction is indicated in grade 3 isolated tears with instability that have not improved with nonoperative management and in instances with associated injuries such as meniscal ramp tears, as observed in this 18-year-old division I football player. Graft selection is dependent upon surgeon and patient preference, with quadriceps autograft delivering a viable option with desirable long-term outcomes. Technique Description: A partial-thickness quadriceps tendon autograft was harvested, the remnant PCL stump was debrided, and a reamer was used to drill the all-inside tibial tunnel for traction suture passage. An accessory low anterolateral portal was utilized to drill the femoral tunnel for passage of the femoral traction stitch. Traction sutures were withdrawn, and the graft was passed into the tibia, docked into the femur, fixated with an interference screw, and tensioned over the tibial button. A medial meniscal ramp tear was also identified and repaired in all-inside fashion with a 90° SutureLasso, polydioxanone suture (PDS), and suturetape via standard arthroscopic knot tying. Following the procedure, the patient began a PCL reconstruction rehabilitation protocol with a PCL rebound brace. Due to the meniscal ramp repair, toe touch weightbearing with the knee in extension during ambulation was completed for 6 weeks. Physical therapy (PT) focused on early quadriceps and patellar mobilization as well as active-assisted range of motion exercises. Results: At 6 months postoperation, the patient continued to progress in PT without major concerns. A full recovery and return to sport are expected approximately 9 to 12 months after surgery, as is consistent with the standard protocol. Discussion/Conclusion: This study describes the treatment of chronic PCL with concomitant meniscal ramp tear in a division I athlete. Further adoption of PCL reconstruction utilizing quadriceps autograft, even in the context of concomitant ligamentous or meniscal reconstruction, such as medial meniscal ramp repair, will aid in the widespread treatment of PCL injuries. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.