bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-temporal high spatial resolution urban scene classification and change detection based on a class-weighted deep adaptation network
Authors: Shi Sunan , Zhong Yanfei , Liu Yinhe , Zhang Liangpei , Li Deren 
Published: January 2024

AbstractMulti-temporal urban scene classification and change analysis based on high resolution (HR) remote sensing imagery can provide reliable time-series information for the semantic interpretation of urban land use and the transitional relationships, which is important information for urban planning and sustainable development. However, there are still some difficulties encountered when applying the existing multi-temporal scene classification methods to analyze urban development in China due to the complex urban structure and scene shape. The main reasons for this can be summarized as follows: 1) the multi-temporal data labeling workload caused by the differences of the data distributions among multi-temporal images; and 2) the lack of practical socio-geographical urban unit boundaries resulting from the uniform grid based segmentation. In this paper, a multi-temporal scene classification framework based on a class-weighted deep adaptation network (CWDAN) is proposed. In the CWDAN framework, multi-temporal OpenStreetMap (OSM) road networks are introduced for the scene segmentation at the land parcel level, to build clear and meaningful geographic boundaries for the scene units. The problem of large scale difference of parcels is solved by area-weighted voting (AWV). In order to solve the problems of the high workload of multi-temporal data labeling in the cross-temporal scene classification task, a gradient reversal layer (GRL) is used in the proposed CWDAN to obtain deep features with invariance relative to the shift between the domains. A class-weighted fully connected layer is used to solve the problem of unbalanced proportion of different urban scene classes. Post-classification is finally performed to obtain the scene change information. Experiments with tri-temporal datasets in Chinese areas demonstrated that the proposed framework can obtain a significantly improved performance in the cross-temporal scene classification and change analysis task.
Microstructure evolution and tribo-oxidation induced by friction and wear of cast iron brake discs
Authors: Luo Quanshun , Shen Jing , Wang Xudong , Farmilo Nick , Guo Xiuhua 
Published: January 2024

AbstractBraking discs play an important role for the safety of vehicles whereas severe frictional contacts in repeated braking operations result in thermal and tribological failures. This paper reports comprehensive surface and subsurface analyses of a used grey cast iron braking disc to investigate its failure mechanisms as well as related microstructure evolution. Thermal cracking, spalling wear and tribo-oxidation have been found to contribute to the wear failure. The flake-type graphite of the grey cast iron triggered propagation and internal oxidation of the metallic matrix. In a depth of 3 mm beneath the rubbing surface, extensive microstructure evolution occurred by severe plastic deformation of the ferritic matrix, nodularisation and partial dissolution of the lamellar carbides, and internal oxidation. The microstructure evolution resulted in decreased surface hardness to HV0.3 247 as compared to HV0.3 284 of the bulk cast iron.
L’égalité des peuples en contexte fédéral ?
Authors: Boileau Xavier 
Published: January 2024

RésuméLes pays ayant une structure politique fédérale sont souvent confrontés aux revendications de leurs États membres pour obtenir plus d'autonomie politique. Pour répondre à ces revendications, les théoriciens du fédéralisme multinational ont proposé de reconnaître un droit à l'autodétermination interne qu'ils ont pris soin d'encadrer de diverses manières. Bien qu'intéressante, cette proposition pourrait toutefois s'avérer insuffisante pour répondre aux inégalités entre les peuples au sein d'une même fédération. C'est la thèse que nous défendrons dans le présent article. Nous montrerons que le concept d'autodétermination interne défendu par Kymlicka reste indéterminé et ouvre la porte à des interprétations plus exigeantes.
A cross-cultural archery analogy in Matteo Ricci's Tianzhu shiyi
Authors: Hosle Paul K. 
Published: January 2024

AbstractIn the sixth chapter of his Tianzhu shiyi (天主實義, “The True Meaning of the Lord of Heaven”), Matteo Ricci offers a critique of the anti-intentionalistic thread that he detects in the Chinese philosophical tradition. In this brief essay, I offer an analysis of a noteworthy archery analogy that Ricci employs to describe the nature of ethical action as an intentional process with a conscious aim. I trace how Ricci skilfully combines Western and Chinese images and categories to craft this simile. Before that, I set the stage by offering some preliminary comments that contextualize Ricci's interest in the question of intentional vs. non-intentional conduct.
Childhood abuse and neglect and profiles of adult emotion dynamics
Authors: Myroniuk S. , Reitsema A. M. , de Jonge P. , Jeronimus B. F. 
Published: January 2024

AbstractChildhood maltreatment (CM) is experienced by ∼40% of all children at major personal and societal costs. The divergent associations between emotional, physical, and sexual abuse or neglect in childhood and differences in adult emotional functioning and regulation were examined in terms of daily emotion intensity, variability, instability, inertia, and diversity, reported over 30 days by 290 Dutch aged 19-73. Participants described their abuse/neglect experiences retrospectively using the Childhood Trauma Questionnaire (CTQ). Dissecting CM effects on adult emotion dynamics may inform theories on the ontogenesis and functioning of emotions, on effects of abuse and neglect, to better understand (dys)functional emotional development, and to prevent their adverse sequelae. Structural equation models (SEM) showed that most types of CM were associated with specific patterns of emotion dynamics, and only emotional abuse had no unique effects on the emotional dynamic indices. Emotional neglect was associated with most measures of emotion dynamics (i.e., less intense, variable, unstable, and diverse emotions). Sexual abuse associated with increases and physical neglect decreases in negative affect variability and instability. Physical abuse was associated with inertia but with a small effect size. Social contact frequency did not mediate much of the relationship between CM types and emotion dynamics.
A construction of free dcpo-cones
Authors: Chen Yuxu , Kou Hui , Lyu Zhenchao , Xie Xiaolin 
Published: January 2024

AbstractWe give a construction of the free dcpo-cone over any dcpo. There are two steps for getting this result. Firstly, we extend the notion of power domain to directed spaces which are equivalent to$T_0$monotone-determined spaces introduced by Erné, and we construct the probabilistic powerspace of the monotone determined space, which is defined as a free monotone determined cone. Secondly, we take D-completion of the free monotone determined cone over the dcpo with its Scott topology. In addition, we show that generally the valuation power domain of any dcpo is not the free dcpo-cone.
Decision support tools for sustainable water management: Lessons learned from two decades of using MULINO-DSS
Authors: Giupponi Carlo , Balabanis Panagiotis , Cojocaru George , F. Vázquez Jacobo , Mysiak Jaroslav 
Published: January 2024

Abstract
In late 2000, the European Union adopted the Water Framework Directive (WFD) and funded a series of research and innovation projects to support its implementation. One of these was the MULINO project (MULti-sectoral, INtegrated and Operational Decision Support System for Sustainable Use of Water Resources at the Catchment Scale). Its main product was a decision support system (mDSS) tool designed to help water managers make choices related to WFD implementation in a participatory manner. After the end of MULINO, a long sequence of research projects allowed for the maintenance and continuous development of its tool, which has been applied for more than 20 years in various contexts related to environmental and integrated management. This experience and an analysis of the literature allow us to draw some general conclusions regarding DSS tools for water management and their role in our societies. Lessons learned are proposed, from the need to frame tools within sound methodological frameworks for the management of decision processes, supporting instead of substituting decision-makers in their roles, to the trade-offs that appear between ease of use and specificity on one side and flexibility and reusability on the other. The specific strengths attributed to mDSS include the provision of an interface based on a simplified and understandable conceptual framework that facilitates communication with interested parties, the flexibility and ability to approach a wide variety of decisional issues, the relatively simple and understandable decision rules provided by the tool, and the simplified connections with other software environments. This paper presents the current version of the software and reports on the experience of its development and use over more than two decades; it also identifies the way forward.
Outcomes of patients with multiple myeloma and 1q gain/amplification receiving autologous hematopoietic stem cell transplant: the MD Anderson cancer center experience
Authors: Pasvolsky Oren , Ghanem Sassine , Milton Denái R. , Rauf Mikael , Tanner Mark R. , Bashir Qaiser , Srour Samer , Saini Neeraj , Lin Paul , Ramdial Jeremy , Nieto Yago , Tang Guilin , Aljawai Yosra , Khan Hina N. , Kebriaei Partow , Lee Hans C. , Patel Krina K. , Thomas Sheeba K. , Weber Donna M. , Orlowski Robert Z. , Shpall Elizabeth J. , Champlin Richard E. , Qazilbash Muzaffar H. 
Published: January 2024

AbstractThe prognostic impact of additional copies of chromosome 1q (1q + ) on outcomes of newly-diagnosed multiple myeloma (NDMM) patients undergoing autologous transplantation (autoSCT) is unclear. We conducted a retrospective single-center analysis of NDMM patients with 1q21 gain/amplification (3 or ≥4 copies of 1q, respectively) that received autoSCT between 2008–2018. 213 patients were included (79% 1q gain; 21% 1q amplification). The most commonly used induction regimen was bortezomib, lenalidomide, and dexamethasone (41%). At day100 post-autoSCT and at best post-transplant response, 78% and 87% of patients achieved ≥VGPR, and 38% and 50% achieved MRD-negative ≥VGPR, respectively. Median PFS and OS for the entire cohort were 35.5 months and 81.4 months, respectively. On multivariable assessment for PFS, MRD negative ≥VGPR before autoSCT (HR 0.52, p = 0.013) was associated with superior PFS, whereas 1q amplification was associated with inferior PFS (2.03, p = 0.003). On multivariate analysis for OS, achieving MRD negative ≥VGPR at best post-transplant response was associated with superior survival (0.29, p < 0.001), whereas R-ISS III and concomitant del17p or t(4:14) were associated with inferior survival (6.95, p = 0.030, 2.33, p = 0.023 and 3.00, p = 0.047, respectively). In conclusion, patients with 1q+ NDMM, especially 1q amplification, have inferior survival outcomes compared to standard-risk disease after upfront autoSCT, though outcomes are better than other high-risk cytogenetic abnormalities.
Intratumoral presence of the genotoxic gut bacteria pks+ E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer
Authors: Joo Jihoon E. , Chu Yen Lin , Georgeson Peter , Walker Romy , Mahmood Khalid , Clendenning Mark , Meyers Aaron L. , Como Julia , Joseland Sharelle , Preston Susan G. , Diepenhorst Natalie , Toner Julie , Ingle Danielle J. , Sherry Norelle L. , Metz Andrew , Lynch Brigid M. , Milne Roger L. , Southey Melissa C. , Hopper John L. , Win Aung Ko , Macrae Finlay A. , Winship Ingrid M. , Rosty Christophe , Jenkins Mark A. , Buchanan Daniel D. 
Published: January 2024

Abstract
Background
This study aimed to investigate clinicopathological and molecular tumour features associated with intratumoral pks+Escherichia coli (pks+E.coli+), pks+E.coli- (non-E.coli bacteria harbouring the pks island), Enterotoxigenic Bacteroides fragilis (ETBF) and Fusobacterium nucleatum (F. nucleatum).

Methods
We screened 1697 tumour-derived DNA samples from the Australasian Colorectal Cancer Family Registry, Melbourne Collaborative Cohort Study and the ANGELS study using targeted PCR.

Results
Pks+E.coli+ was associated with male sex (P < 0.01) and APC:c.835-8 A > G somatic mutation (P = 0.03). The association between pks+E.coli+ and APC:c.835-8 A > G was specific to early-onset CRCs (diagnosed<45years, P = 0.02). The APC:c.835-A > G was not associated with pks+E.coli- (P = 0.36). F. nucleatum was associated with DNA mismatch repair deficiency (MMRd), BRAF:c.1799T>A p.V600E mutation, CpG island methylator phenotype, proximal tumour location, and high levels of tumour infiltrating lymphocytes (Ps < 0.01). In the stratified analysis by MMRd subgroups, F. nucleatum was associated with Lynch syndrome, MLH1 methylated and double MMR somatic mutated MMRd subgroups (Ps < 0.01).

Conclusion
Intratumoral pks+E.coli+ but not pks+E.coli- are associated with CRCs harbouring the APC:c.835-8 A > G somatic mutation, suggesting that this mutation is specifically related to DNA damage from colibactin-producing E.coli exposures. F. nucleatum was associated with both hereditary and sporadic MMRd subtypes, suggesting the MMRd tumour microenvironment is important for F. nucleatum colonisation irrespective of its cause.
LanDis: the disease landscape explorer
Authors: Caniza Horacio , Cáceres Juan J. , Torres Mateo , Paccanaro Alberto 
Published: January 2024

AbstractFrom a network medicine perspective, a disease is the consequence of perturbations on the interactome. These perturbations tend to appear in a specific neighbourhood on the interactome, the disease module, and modules related to phenotypically similar diseases tend to be located in close-by regions. We present LanDis, a freely available web-based interactive tool (https://paccanarolab.org/landis) that allows domain experts, medical doctors and the larger scientific community to graphically navigate the interactome distances between the modules of over 44 million pairs of heritable diseases. The map-like interface provides detailed comparisons between pairs of diseases together with supporting evidence. Every disease in LanDis is linked to relevant entries in OMIM and UniProt, providing a starting point for in-depth analysis and an opportunity for novel insight into the aetiology of diseases as well as differential diagnosis.
Field-induced bound-state condensation and spin-nematic phase in SrCu2(BO3)2 revealed by neutron scattering up to 25.9 T
Authors: Fogh Ellen , Nayak Mithilesh , Prokhnenko Oleksandr , Bartkowiak Maciej , Munakata Koji , Soh Jian-Rui , Turrini Alexandra A. , Zayed Mohamed E. , Pomjakushina Ekaterina , Kageyama Hiroshi , Nojiri Hiroyuki , Kakurai Kazuhisa , Normand Bruce , Mila Frédéric , Rønnow Henrik M. 
Published: January 2024

AbstractIn quantum magnetic materials, ordered phases induced by an applied magnetic field can be described as the Bose-Einstein condensation (BEC) of magnon excitations. In the strongly frustrated system SrCu2(BO3)2, no clear magnon BEC could be observed, pointing to an alternative mechanism, but the high fields required to probe this physics have remained a barrier to detailed investigation. Here we exploit the first purpose-built high-field neutron scattering facility to measure the spin excitations of SrCu2(BO3)2 up to 25.9 T and use cylinder matrix-product-states (MPS) calculations to reproduce the experimental spectra with high accuracy. Multiple unconventional features point to a condensation of S = 2 bound states into a spin-nematic phase, including the gradients of the one-magnon branches and the persistence of a one-magnon spin gap. This gap reflects a direct analogy with superconductivity, suggesting that the spin-nematic phase in SrCu2(BO3)2 is best understood as a condensate of bosonic Cooper pairs.
Scalable integrated two-dimensional Fourier-transform spectrometry
Authors: Xu Hongnan , Qin Yue , Hu Gaolei , Tsang Hon Ki 
Published: January 2024

AbstractIntegrated spectrometers offer the advantages of small sizes and high portability, enabling new applications in industrial development and scientific research. Integrated Fourier-transform spectrometers (FTS) have the potential to realize a high signal-to-noise ratio but typically have a trade-off between the resolution and bandwidth. Here, we propose and demonstrate the concept of the two-dimensional FTS (2D-FTS) to circumvent the trade-off and improve scalability. The core idea is to utilize 2D Fourier transform instead of 1D Fourier transform to rebuild spectra. By combining a tunable FTS and a spatial heterodyne spectrometer, the interferogram becomes a 2D pattern with variations of heating power and arm lengths. All wavelengths are mapped to a cluster of spots in the 2D Fourier map beyond the free-spectral-range limit. At the Rayleigh criterion, the demonstrated resolution is 250 pm over a 200-nm bandwidth. The resolution can be enhanced to 125 pm using the computational method.
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model
Authors: Morrone Parfitt Gustavo , Coccia Elena , Goldman Camille , Whitney Kristen , Reyes Ricardo , Sarrafha Lily , Nam Ki Hong , Sohail Soha , Jones Drew R. , Crary John F. , Ordureau Alban , Blanchard Joel , Ahfeldt Tim 
Published: January 2024

AbstractAccumulation of advanced glycation end products (AGEs) on biopolymers accompanies cellular aging and drives poorly understood disease processes. Here, we studied how AGEs contribute to development of early onset Parkinson’s Disease (PD) caused by loss-of-function of DJ1, a protein deglycase. In induced pluripotent stem cell (iPSC)-derived midbrain organoid models deficient for DJ1 activity, we find that lysosomal proteolysis is impaired, causing AGEs to accumulate, α-synuclein (α-syn) phosphorylation to increase, and proteins to aggregate. We demonstrated these processes are at least partly driven by astrocytes, as DJ1 loss reduces their capacity to provide metabolic support and triggers acquisition of a pro-inflammatory phenotype. Consistently, in co-cultures, we find that DJ1-expressing astrocytes are able to reverse the proteolysis deficits of DJ1 knockout midbrain neurons. In conclusion, astrocytes’ capacity to clear toxic damaged proteins is critical to preserve neuronal function and their dysfunction contributes to the neurodegeneration observed in a DJ1 loss-of-function PD model.
Elucidating protonation pathways in CO2 photoreduction using the kinetic isotope effect
Authors: Yin Shikang , Zhou Yiying , Liu Zhonghuan , Wang Huijie , Zhao Xiaoxue , Zhu Zhi , Yan Yan , Huo Pengwei 
Published: January 2024

AbstractThe surge in anthropogenic CO2 emissions from fossil fuel dependence demands innovative solutions, such as artificial photosynthesis, to convert CO2 into value-added products. Unraveling the CO2 photoreduction mechanism at the molecular level is vital for developing high-performance photocatalysts. Here we show kinetic isotope effect evidence for the contested protonation pathway for CO2 photoreduction on TiO2 nanoparticles, which challenges the long-held assumption of electron-initiated activation. Employing isotopically labeled H2O/D2O and in-situ diffuse reflectance infrared Fourier transform spectroscopy, we observe H+/D+-protonated intermediates on TiO2 nanoparticles and capture their inverse decay kinetic isotope effect. Our findings significantly broaden our understanding of the CO2 uptake mechanism in semiconductor photocatalysts.
Extrapolative prediction of small-data molecular property using quantum mechanics-assisted machine learning
Authors: Shimakawa Hajime , Kumada Akiko , Sato Masahiro 
Published: January 2024

AbstractData-driven materials science has realized a new paradigm by integrating materials domain knowledge and machine-learning (ML) techniques. However, ML-based research has often overlooked the inherent limitation in predicting unknown data: extrapolative performance, especially when dealing with small-scale experimental datasets. Here, we present a comprehensive benchmark for assessing extrapolative performance across 12 organic molecular properties. Our large-scale benchmark reveals that conventional ML models exhibit remarkable performance degradation beyond the training distribution of property range and molecular structures, particularly for small-data properties. To address this challenge, we introduce a quantum-mechanical (QM) descriptor dataset, called QMex, and an interactive linear regression (ILR), which incorporates interaction terms between QM descriptors and categorical information pertaining to molecular structures. The QMex-based ILR achieved state-of-the-art extrapolative performance while preserving its interpretability. Our benchmark results, QMex dataset, and proposed model serve as valuable assets for improving extrapolative predictions with small experimental datasets and for the discovery of novel materials/molecules that surpass existing candidates.
Action prediction in psychosis
Authors: Montobbio Noemi , Zingarelli Enrico , Folesani Federica , Memeo Mariacarla , Croce Enrico , Cavallo Andrea , Grassi Luigi , Fadiga Luciano , Panzeri Stefano , Belvederi Murri Martino , Becchio Cristina 
Published: January 2024

AbstractAberrant motor-sensory predictive functions have been linked to symptoms of psychosis, particularly reduced attenuation of self-generated sensations and misattribution of self-generated actions. Building on the parallels between prediction of self- and other-generated actions, this study aims to investigate whether individuals with psychosis also demonstrate abnormal perceptions and predictions of others’ actions. Patients with psychosis and matched controls completed a two-alternative object size discrimination task. In each trial, they observed reaching actions towards a small and a large object, with varying levels of temporal occlusion ranging from 10% to 80% of movement duration. Their task was to predict the size of the object that would be grasped. We employed a novel analytic approach to examine how object size information was encoded and read out across progressive levels of occlusion with single-trial resolution. Patients with psychosis exhibited an overall pattern of reduced and discontinuous evidence integration relative to controls, characterized by a period of null integration up to 20% of movement duration, during which they did not read any size information. Surprisingly, this drop in accuracy in the initial integration period was not accompanied by a reduction in confidence. Difficulties in action prediction were correlated with the severity of negative symptoms and impaired functioning in social relationships.