bluuebunny/crossref_metadata_2025_split huggingface dataset:
Niraparib in the treatment of ovarian cancer: A comprehensive review
Authors: Sharma Chetan , Badyal Dinesh Kumar 
Published: December 2023

Abstract:
Niraparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has emerged as a promising therapeutic option in the management of ovarian cancer. Ovarian cancer remains a significant global health concern, often diagnosed at an advanced stage with limited treatment options. The PARP inhibitors have revolutionized the therapeutic landscape by exploiting deficiencies in DNA repair pathways, particularly in tumors with homologous recombination deficiencies. Niraparib, a selective PARP-1/2 inhibitor, has shown promising results in various clinical settings, making it a subject of intense research. This review aims to provide a comprehensive overview of the current state of knowledge regarding the efficacy, safety, and clinical implications of niraparib in the treatment of ovarian cancer.
Performance of chatGPT-3.5 answering questions from the Brazilian Council of Ophthalmology Board Examination
Authors: Gobira Mauro C. , Moreira Rodrigo C. , Nakayama Luis F. , Regatieri Caio V. S. , Andrade Eric , Rubens Belfort 
Published: December 2023

Importance:
Large language models being approved in medical boarding examinations highlights problems and challenges for healthcare education, improving tests, and deployment of chatbots.

Objective:
The objective of this study was to evaluate the performance of ChatGPT-3.5 in answering the Brazilian Council of Ophthalmology Board Examination.

Material and Methods:
Two independent ophthalmologists inputted all questions to ChatGPT-3.5 and evaluated the responses for correctness, adjudicating in disagreements. We compared the performance of the ChatGPT across tests, ophthalmological themes, and mathematical questions. The included test was the 2022 Brazilian Council of Ophthalmology Board Examination which consists of theoretical test I, II, and theoretical–practical.

Results:
ChatGPT-3.5 answered 68 (41.46%) questions correctly, 88 (53.66%) wrongly, and 8 (4.88%) undetermined. In questions involving mathematical concepts, artificial intelligence correctly answered 23.8% of questions. In theoretical examinations I and II, correctly answered 43.18% and 40.83%, respectively. There was no statistical difference (odds ratio 1.101, 95% confidence interval 0.548–2.215, P = 0.787) comparing correct answers between tests and comparing within the test themes (P = 0.646) for correct answers.

Conclusion and Relevance:
Our study shows that ChatGPT would not succeed in the Brazilian ophthalmological board examination, a specialist-level test, and struggle with mathematical questions. Poor performance of ChatGPT can be explained by a lack of adequate clinical data in training and problems in question formulation, with caution recommended in deploying chatbots for ophthalmology.
Giant cell arteritis: Is there a link between ocular and systemic involvement?
Authors: Portela Mariana G , Correia Marta R , Baptista Margarida L , Bruxelas Carolina P , Pinto Daniel , Costa João M 
Published: December 2023

Introduction:
Giant cell arteritis (GCA) is a systemic disease that may cause severe visual loss. Our purpose was to determine which factors contribute to ocular manifestations (OMs) in patients with temporal artery biopsy-proven GCA.

Methods:
This was a retrospective review of all cases diagnosed in our center from 2010 to 2021 (>6 months follow-up). We analyzed demographic data, comorbidities, type and duration of symptoms before diagnosis, ocular features, and systemic and laboratory findings.

Results:
Out of 51 patients (60.8% females, mean age 74.8 ± 13.5), 32 (63%) had OM, of whom 28% had transient visual loss, 69% had permanent visual loss, and 9% had diplopia. Apart from scalp tenderness (P = 0.039), OM did not correlate with other ischemic symptoms such as jaw claudication or headache and were even significantly associated with the absence of fever (P = 0.026). Patients with OM also showed lower values of C-reactive protein (CRP) (P = 0.045).

Conclusion:
In our sample, visual involvement was not significantly associated with any systemic symptom apart from scalp tenderness, which highlights the importance of having a high index of suspicion for GCA in an ophthalmology setting, especially in older patients with visual loss. Furthermore, OMs were significantly associated with the absence of fever and lower values of CRP which may suggest a lower inflammatory state may in these patients.
Dufourmentel Rhomboid Flap versus the Karydakis and Bascom Flap Reconstruction Following Wide Excision of Pilonidal Sinus Disease
Authors: Chee Madeline Y. M. , Goh Cindy S. L. , Pek Wan S. , Tan Emile K.-W. , Seow-En Isaac 
Published: December 2023

Abstract

Background:
Primary closure of the defect following radical excision of pilonidal sinus disease often has high complication rates.

Objectives:
This study aims to compare the outcomes of the Karydakis and Bascom off-midline flap closure techniques with the more recently described Dufourmentel rhomboid flap technique.

Design:
Retrospective cohort study.

Setting:
Patients who underwent elective pilonidal sinus excision with flap reconstruction at a tertiary referral center from January 2019 to January 2023.

Patients and Methods:
De-identified data of patients who underwent elective pilonidal sinus excision with flap reconstruction at a tertiary referral center from January 2019 to January 2023 were analyzed. Patients who underwent pilonidal sinus surgery without flap reconstruction were not included in the analysis. Institutional ethical committee review was waived for this study.

Main Outcome Measures:
Wound healing time, postoperative complications, disease recurrence, operative duration, and length of hospital stay.

Sample Size:
Forty-four patients.

Results:
Over a 4-year duration, 44 patients had elective pilonidal sinus surgery, of whom 44 (36 men, eight women) underwent flap reconstruction of the defect. Mean age and body mass index was 25.6 years and 26.6 kg/m2, respectively. The overall mean complete wound healing time was 10.8 weeks, with the Dufourmentel group having the quickest healing time compared to the Karydakis and Bascom groups (6.1 weeks versus 10.8 weeks versus 13.9 weeks, respectively; P = 0.206) At a mean follow-up duration of 8 months, 18 (40.1%) patients developed postoperative wound complications. Overall wound complication rate was lowest in the Dufourmentel group (9.1% versus 52.9% versus 56.3%, respectively; P = 0.030). This was largely contributed by the reduced wound dehiscence rate (9.1% versus 35.3% versus 56.3%, respectively; P = 0.043). The rates of wound infection, sinus recurrence, and reoperation were low and statistically comparable across all three groups.

Conclusion:
Our findings suggest the superiority of the Dufourmentel flap reconstruction technique compared to the Karydakis and Bascom closure techniques following elective pilonidal sinus excision.

Limitations:
Retrospective study with a small sample size and short follow-up duration.

Conflict of Interest:
The authors have no conflict of interest to declare.
Endoscopic radiating incision combined with balloon dilation for the treatment of obstructed anastomosis in the diverted colon
Authors: Jing Songqi , Zhang Jinpeng , Ren Huajian , Wang Huangkai , Tian Ruixia , Wang Gefei , Wang Zhiming , Ren Jianan 
Published: December 2023

Abstract
Anastomotic stricture (AS) is a significant complication following colorectal surgery. Endoscopic balloon dilation (EBD) is commonly employed as the safest and most widely used technique for treating AS. However, the conventional EBD methods are ineffective in completely occluded AS. This case report presents a successful treatment of a complete AS in a 54-year-old Chinese woman using endoscopic incision and EBD. Initially, an endoscopic incision was performed to open the stricture, followed by gradual dilation with a cylindrical balloon catheter. The patient’s AS was successfully resolved, as confirmed by a follow-up colonoscopy 1 month after the procedure, revealing an open anastomosis with well-healed mucosa. These findings suggest that the combination of endoscopic incision and EBD represents a promising novel approach for managing completely occluded AS.
PROFIL POTENCIÁLNÍHO UŽIVATELE URBAN AIR MOBILITY V ČESKÉ REPUBLICE
Authors: Šimeček Michal 
Published: December 2023

Městská letecká mobilita (UAM) je nově vznikající koncept letecké dopravy, ve kterém drony přepravují cestující nebo náklad v hustě obydlených oblastech. UAM umožňuje výrazné zkrácení cestovních časů a obchází dopravní zácpy tím, že umožňuje leteckou dopravu z jednoho místa na druhé v rámci urbanizovaných oblastí. Než však bude možné UAM implementovat, je třeba vyřešit několik problémů, včetně technických problémů. Společenská akceptace a vytvoření životaschopného obchodního modelu jsou také pro rozvoj UAM důležité. Průzkum popsaný v tomto příspěvku má za cíl identifikovat profil potenciálního uživatele UAM. Výsledky naznačují poměrně vysokou ochotu přijmout UAM, přičemž přibližně 77 % respondentů projevilo zájem, zejména pokud by cesta UAM začala z jejich rezidenční oblasti. Logistická regresní analýza odhalila, že pohlaví, vzdělání, zaměstnanecký status, vzorce používání vozidel, frekvence cestování letadlem a motivační faktory, jako je využití cestovního času a rychlost cestování, významně ovlivnily pravděpodobnost použití UAM. Tato zjištění přispívají k pochopení potenciálního uživatelského profilu UAM.
Cost and Time Analysis of the Construction of the 275 Kv 2cct Quadruple Zebra Sutet Project Gumawang – Gitet Lampung 1 Using the Time Cost Trade Off Method
Authors: Adam Ijaz , Witjaksana Budi , TJendani Hanie Teki 
Published: December 2023

Indonesia as an archipelago state is still need an equality development with the intention in achieving the goals to fulfil the requirement of structure and infrastructure. The economy that has experiencing growth, it can be see with the rising of the demand for supply of electricity power whether it is coming from domestic moreover from industrial usages. Lampung Province, as one of the regions which in a continuation to develop, requires the support of electric power, which at its peak load reaches 1200 MW, while the capacity of existing power plant can only produce 700 MW, therefore the construction of a 275 kV Gumawang-Lampung 1 SUTET interconnection network with a capacity of up to 2000 MW was established to meet these requirement.Based on the time schedule which noted that the duration of foundation work started with the excavation, concreting until the reaches of it’s curing time in 28 days is 42 days in 2023 December 13th is on try to speed up can be curing in 2023 December 8th, so the schedule tower installation in 2023 December 9th will be on time. Due to this delay, the researcher intends to carry out an acceleration analysis starting with preparing a network diagram using the Microsoft Project software, followed by the crashing process by adding groups of workers and tools of any activities on the critical path. The next step is to calculate the crash cost and cost slope values ??using the time cost trade off (TCTO) method.From the results of the analysis carried out, it was found that the normal project duration was 42 days after the crashing process was carried out to 36 days, with a normal work cost of Rp. 1,774,462,352.84 and after the crashing process was carried out with the alternative of adding labor groups and equipment the cost became Rp. 1,849,762,666.92. It was concluded that with the time cost trade off method there was a reduction in duration and an increase in costs.
Tecnologías de Información Geográfica aplicadas al estudio espacio-temporal de un incendio. Estudio de caso: Parque Nacional Pilcomayo – Formosa - Argentina (Septiembre 2015)
Authors: Valania María Paula 
Published: December 2023

El trabajo analiza la utilidad de la aplicación de herramientas del ámbito de las Tecnologías de la Información Geográfica (TIG), tales como la teledetección y los Sistemas de Información Geográfica (SIG), en el estudio espacial y temporal de un incendio. Como caso de estudio se ha considerado un evento de este tipo que involucró una vasta cobertura de pastizales naturales, ocurrido en zona de humedales en el Parque Nacional Pilcomayo, Formosa (Argentina), en septiembre de 2015.
A través del procesamiento y análisis de datos espectrales, obtenidos a partir de teledetección satelital, pudieron definirse: las características del evento (inicio, propagación, extensión y duración), la dinámica presentada por la cobertura vegetal dominante con posterioridad al incendio, así como también identificarse patrones de su recurrencia histórica para el área de estudio (AE). Para ello se trabajó con diversos productos e imágenes satelitales a diferentes escalas temporales (previas, simultáneas y posteriores al evento en análisis); su interpretación y procesamiento, mediante el cálculo de índices espectrales, permitió caracterizar el incendio en cuanto a los aspectos de interés señalados.
El estudio de caso abordado presenta un claro ejemplo de cómo las TIG permiten realizar un seguimiento continuo, actualizado y económicamente viable de los incendios, a distintas escalas espaciales y para diferentes tipos de usuarios, tanto para científicos como para los tomadores de decisión.

Abstract
This work analyzes the usefulness of applying tools from the field of Geographic Information Technologies (GIT), such as remote sensing and Geographic Information Systems (GIS), in the spatial and temporal study of a fire. This case study analyzed a disturbance of this type involving a vast natural grassland cover, which occurred in a wetland area in Pilcomayo National Park, Formosa province, Argentina, in September 2015.
Through the processing and analysis of satellite data, it was possible to define the characteristics of the event, namely onset, propagation, extent, and duration, the dynamics exhibited by the dominant vegetation cover following the disturbance, and the historical recurrence patterns of the event for the Study Area (SA) analyzed. To achieve this, various satellite products and images before, during, and after the disturbance were used. They were processed and interpreted by calculating spectral indices, which allowed for the characterization of the fire event in terms of the aspects of interest above mentioned.
This case study provides a clear example of how satellite remote sensing technologies enable continuous, up-to-date, and economically viable monitoring of fires at different spatial scales and for various types of users, including both scientists and policymakers.
Conocimiento tradicional en el manejo de especies arbóreas tintóreas por artesanas mayas en Yucatán, México
Authors: Jiménez Anell Danell , Ruenes Morales Rocío , Montañez Escalante Patricia , Aguilar Cordero Wilian 
Published: December 2023

La presente investigación analizó la estructura y composición de las especies arbóreas en la vegetación de los sitios de colecta de los artesanos de Sahcabá, Yucatán, México, además de documentar el conocimiento tradicional y el manejo de especies tintóreas. Se aplicaron 99 cuestionarios y 10 entrevistas. Se seleccionaron 10 sitios para el muestreo de vegetación, se marcaron cuadros de 10x10m, se midió la altura y diámetro a individuos con un DAP ≥ 10cm, se hicieron colectas botánicas para su identificación taxonómica. Los resultados de los muestreos de vegetación señalan ocho especies arbóreas tintóreas, la más abundante y frecuente fue Lysiloma latisiliquum. En las entrevistas los habitantes mencionaron 18 especies tintóreas de las cuales 14 son arbóreas y cuatro se identificaron en la vegetación. El conocimiento tradicional sobre el aprovechamiento de plantas tintóreas para la elaboración de artesanías se trasmite de generación en generación y fundamentalmente es a través de las relaciones de parentesco. La comunidad artesanal aplica grados y formas de manejo incipiente hacia especies tintóreas que se encuentran en la selva.

Abstract
This research analyzed the structure and composition of tree species in the artisans’ vegetation in artisan collecting sites from Sahcabá and documented traditional knowledge and management of dyes species. We applied 99 questionnaires and 10 interviews. Ten sites were selected for vegetation sampling, 10x10 m plots were marked, individuals were measured in height and diameter to individuals with DBH ≥ 10 cm, and botanical collections were made for taxonomic identification. Vegetation sampling results pointed indicated eight tree species; the most abundant and frequent was being Lysiloma latisiliquum. In the interviews, people mentioned 18 dyes species, out of which 14 were arboreal and they were agree with only four of the species recorded in the vegetation sampling. Traditional knowledge is transmitted from generation to generation and primarily throughout kinship. ArThe artisan community of Sahcabá applied management forms and degrees to dyes species.
Analisis Hukum Internasional Tentang State Sponsored Terrorism
Authors: Corputty Frandy Army , Wattimena Josina Augustina Yvonne , Peilouw Johanis Steny Franco 
Published: December 2023

Introduction: State is one of the subjects of international law that has the responsibility to protect the human rights of every individual within its sovereign territory. However, the facts show that there are countries that become sponsors or in other words the state provides support either directly or indirectly to terrorist groups to carry out their actions. This term is known as state sponsored terrorism which requires global attention considering that terrorism cases that occur often have links to the state.Purposes of the Research: 1. Review and discuss the regulation of State Sponsored Terrorism in International Law. 2. Review and discuss the implications for the enforcement of International Law.Methods of the Research: This study uses a normative juridical method with an analytical perspective using primary, secondary, and tertiary legal materials. This research technique is a literature study based on international legal regulations, scientific works and other literature related to state sponsored terrorism.Results of the Research: International law arrangements related to state sponsored terrorism still require special attention due to the large number of cases and indications of states being involved. Given that state sponsored terrorism is the root of various terrorism cases around the world. This shows that the international legal instruments that existed before the International Convention for the Suppression of the Financing Terrorism and United Nations Convention Against Transnational Organized Crime were considered unable to prevent and prohibit countries from sponsoring terrorists caused by the absence of the universal definition of terrorism. It is proven by international violations committed by sponsoring countries in order to fulfill their country's interests. State sponsored terrorism can also be considered as a problem for the protection of human rights. This can be seen when a sponsored terror act results in a violation of the right to life and the right to feel safe of every individual who is within the sovereign territory of the target country. The implication of state sponsored terrorism then causes overlapping jurisdictions between the International Court of Justice and the Security Council in enforcing international law so that the settlement of cases is still unclear.
Pengaturan Tentang Penerbangan Komersial Dan Tanggung Jawab Negara
Authors: Hardianti Hardianti , Hanafi Irma Halimah , Riry Welly Angela 
Published: December 2023

Introduction: In transportation activities, the risk of an accident is an unavoidable thing so that unification of arrangements regarding this matter is an absolute thing to do.Purposes of the Research: This study aims to find out and examine how the regulation regarding the flight of commercial aircraft in the air space of a country is reviewed from international law and how the form of state responsibility when a commercial aircraft is shot down is reviewed from international law Methods of the Research: This writing uses a normative type of legal research, which is carried out by studying theories, concepts, legal principles, and laws and regulations. In this study, the author used 2 approaches, namely the statutory approach, and the case approach.Results of the Research: The results showed that the International air law Regulation related to the parties' obligation to regulate the safety of commercial flights crossing its airspace must be in accordance with the Chicago Convention of 1944. These arrangements are made so that flights that cross the airspace of other countries can be kept safe and secure. Iran's shooting down of Ukrainian plane PS752 has violated provisions in the 1944 Chicago Convention on its airspace in an armed dispute. Therefore, Iran must take responsibility for this incident. In the future, firmness and increased cooperation with various parties are needed so that safety and security in international flights and national flights can be achieved.
Yurisdiksi Negara Pantai Terhadap Kapal Asing Yang Memuat Limbah Bahan Berbahaya Dan Beracun (B3) Ditinjau Dari Hukum Laut Internasional
Authors: Djunaidi Muhamad Renaldy , Tuhulele Popi , Daties Dyah Ridhul Airin 
Published: December 2023

Introduction: The jurisdiction of the coastal state is an authority of the state to carry out laws and regulations in its territorial area to regulate people, property, and events that occur in the land area, sea waters, and air space above it.Methods of the Research: The research method used is normative juridical. by using a problem approach such as a statutory approach, a conceptual approach and a case approach. While the sources of legal materials used are primary, secondary and tertiary sources of legal materials. The collection of legal materials is carried out by means of a literature study, then analyzed qualitatively. Results of the Research: The results show that the entry of foreign ships transporting waste in the jurisdiction of the coastal state is not prohibited as long as it is subject to the provisions for the transportation of hazardous and toxic waste that is passing through the territory of the coastal state, namely for foreign ships carrying nuclear or other goods which because of their nature dangerous or toxic, if you want to make a voyage in the territorial waters of an International country, you must carry documents and comply with special precautions established by International treaties for ships (Article 23 of the 1982 International Law Of The Sea Convention). The implementation of Indonesian Jurisdiction for foreign ships transporting waste has been regulated in Law Number 17 of 2008 concerning Shipping and Government Regulation Number 101 of 2014 concerning Management of Hazardous and Toxic Waste, which explains all matters relating to traffic through waters, transportation of dangerous goods and special goods by sea, determination of hazardous and toxic waste, management of hazardous and toxic waste, navigation in sea transportation including aspects of shipping safety and security.