bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic characterization of neoplastic and non-neoplastic lesions in inflammatory bowel disease: systematic review in the era of advanced endoscopic imaging
Authors: Cassinotti Andrea , Parravicini Marco , Chapman Thomas P. , Balzarini Marco , Canova Lorenzo , Segato Simone , Zadro Valentina , Travis Simon , Segato Sergio 
Published: November 2023

Background: Current guidelines strongly recommend the use of validated classifications to support optical diagnosis of lesions with advanced endoscopic imaging in the lower gastrointestinal tract. However, the optimal strategy in inflammatory bowel disease (IBD) is still a matter of debate. Objectives: To analyze the accuracy of endoscopic classifications or single predictors for in vivo lesion characterization during endoscopic surveillance of IBD with advanced endoscopic imaging. Design: Systematic review. Data sources and methods: Medline and PubMed were used to extract all studies which focused on lesion characterization of neoplastic and non-neoplastic lesions in IBD. The diagnostic accuracy of endoscopic classifications and single endoscopic predictors for lesion characterization were analyzed according to type of patients, lesions, and technology used. When available, the rates of true and false positives or negatives for neoplasia were pooled and the sensitivity (SE), specificity (SP), positive predictive value, and negative predictive value (NPV) were calculated. Results: We included 35 studies (2789 patients; 5925 lesions – 1149 neoplastic). Advanced endoscopic imaging included dye-based chromoendoscopy, virtual chromoendoscopy (VCE), magnification and high-definition endoscopy, confocal laser endomicroscopy (CLE), endocytoscopy, and autofluorescence imaging. The Kudo classification of pit patterns was most frequently used, with pooled SE 83%, SP 83%, and NPV 95%. The endoscopic criteria with the highest accuracy, with minimum SE ⩾ 90%, SP ⩾ 80%, and NPV ⩾ 90% were: the Kudo-IBD classification used with VCE (Fuji Intelligent Color Enhancement and i-SCAN); combined irregular surface and vascular patterns used with narrow band imaging; the Mainz classification used with CLE. Multiple clinical and technical factors were found to influence the accuracy of optical diagnosis in IBD. Conclusion: No single endoscopic factor has yet shown sufficient accuracy for lesion characterization in IBD surveillance. Conventional classifications developed in the non-IBD setting have lower accuracy in IBD. The use of new classifications adapted for IBD (Kudo-IBD), and new technologies based on in vivo microscopic analysis show promise.
Adult Cervical Deformity Patients Have Higher Baseline Frailty, Disability, and Comorbidities Compared With Complex Adult Thoracolumbar Deformity Patients: A Comparative Cohort Study of 616 Patients
Authors: Smith Justin S. , Kelly Michael P. , Buell Thomas J , Ben-Israel David , Diebo Bassel , Scheer Justin K , Line Breton , Lafage Virginie , Lafage Renaud , Klineberg Eric , Kim Han Jo , Passias Peter , Gum Jeffrey L. , Kebaish Khal , Mullin Jeffrey P. , Eastlack Robert , Daniels Alan , Soroceanu Alex , Mundis Gregory , Hostin Richard , Protopsaltis Themistocles S. , Hamilton D. Kojo , Gupta Munish , Lewis Stephen J. , Schwab Frank J. , Lenke Lawrence G. , Shaffrey Christopher I. , Burton Douglas , Ames Christopher P. , Bess Shay ,   On Behalf of the International Spine Study Group
Published: November 2023

Study Design Multicenter comparative cohort. Objective Studies have shown markedly higher rates of complications and all-cause mortality following surgery for adult cervical deformity (ACD) compared with adult thoracolumbar deformity (ATLD), though the reasons for these differences remain unclear. Our objectives were to compare baseline frailty, disability, and comorbidities between ACD and complex ATLD patients undergoing surgery. Methods Two multicenter prospective adult spinal deformity registries were queried, one ATLD and one ACD. Baseline clinical and frailty measures were compared between the cohorts. Results 616 patients were identified (107 ACD and 509 ATLD). These groups had similar mean age (64.6 vs 60.8 years, respectively, P = .07). ACD patients were less likely to be women (51.9% vs 69.5%, P < .001) and had greater Charlson Comorbidity Index (1.5 vs .9, P < .001) and ASA grade (2.7 vs 2.4, P < .001). ACD patients had worse VR-12 Physical Component Score (PCS, 25.7 vs 29.9, P < .001) and PROMIS Physical Function Score (33.3 vs 35.3, P = .031). All frailty measures were significantly worse for ACD patients, including hand dynamometer (44.6 vs 55.6 lbs, P < .001), CSHA Clinical Frailty Score (CFS, 4.0 vs 3.2, P < .001), and Edmonton Frailty Scale (EFS, 5.15 vs 3.21, P < .001). Greater proportions of ACD patients were frail (22.9% vs 5.7%) or vulnerable (15.6% vs 10.9%) based on EFS ( P < .001). Conclusions Compared with ATLD patients, ACD patients had worse baseline characteristics on all measures assessed (comorbidities/disability/frailty). These differences may help account for greater risk of complications and all-cause mortality previously observed in ACD patients and facilitate strategies for better preoperative optimization.
Management of Hand and Wrist Injuries in NCAA Division I Football Players From a Single Institution: Factors Associated With Epidemiology, Surgical Intervention, and Return to Play
Authors: Bougioukli Sofia , Bolia Ioanna K. , Mayfield Cory K. , Nicholson Luke T. , Weber Alexander E. , Bashrum Bryan S. , Romano Russell , Tibone James E. , Shin Steven , Gamradt Seth C. 
Published: November 2023

Background: Upper extremity injuries account for approximately 16.9% of football injuries in the National Collegiate Athletic Association (NCAA). Purpose: To determine the epidemiology, management, and outcomes of hand/wrist injuries in collegiate football athletes so as to identify factors associated with surgical intervention and delayed return to play (RTP). Study Design: Descriptive epidemiology study. Methods: We retrospectively reviewed hand/wrist injuries that occurred within a single NCAA Division I football team from January 1, 2003, to December 31, 2020. Data analyzed included player position, college seniority, injury characteristics, injury management, surgical procedures performed, and timing of RTP. A univariate analysis was performed to identify factors associated with increased risk for surgical intervention and delayed (>21 days) RTP after hand and wrist injury in this cohort. Results: Overall, 124 patients with 168 hand/wrist injuries were identified (9.9 wrist/hand injuries per year). Sprain of the thumb metacarpophalangeal (MCP) joint ulnar collateral ligament (UCL) was the most common diagnosis (19.6%). Surgery was required in 22% of injuries, with injury of the UCL of the thumb MCP joint (8/37) being the most common indication. Injuries occurring during competitive games (odds ratio = 4.29; 95% CI, 1.2-15.9) were associated with an increased risk for surgery. Most (70%) injuries did not lead to time missed from football, whereas the remaining 30% resulted in an average of 33 ± 36 days missed. Conclusion: Over 17 athletic seasons, the annual incidence of hand and wrist injury in these NCAA Division I football players was 9.9 injuries per year, with 22% requiring surgical treatment. Injury to the UCL of the thumb MCP joint was the most common injury and indication for surgery, and 30% of injuries resulted in approximately 1 month lost. Injuries sustained in games were associated with operative management and delayed RTP.
Intraobserver and Interobserver Reliability of the Snyder and Expanded SLAP Classification System: A Video Study
Authors: Hahn Alexander K. , Holmberg Kyle , Hammarstedt Jon E. , Philp Frances , DeMeo Patrick , Lai Vince J. , Kindya Michael Christopher , Paci James Michael , Farrow Lutul D. , Vardiabasis Nicolas , Nye Darin , Frey Steven , Moutzouros Vasilios , Purnell Gregory J. , Wang Patrick , Vaccariello Michael , Schweizer Scott K. , Phillips Dennis J. , Frank Darren A. , Akhavan Sam 
Published: November 2023

Background: Superior labral anterior and posterior (SLAP) tears are a common finding in overhead athletes. The original classification system produced by Snyder in 1990 contained 4 types of SLAP tears and was later expanded to 10 types. The classification has been challenging because of inconsistencies between surgeons making diagnoses and treatments based on the diagnosis. Furthermore, patient factors—such as age and sports played—affect the treatment algorithms, even across similarly classified SLAP tears. Purpose: To (1) assess the interobserver and intraobserver reliability of the Snyder and expanded SLAP (ESLAP) classification systems and (2) determine the consistency of treatment for a given SLAP tear depending on different clinical scenarios. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: A total of 20 arthroscopic surgical videos and magnetic resonance imaging scans of patients with SLAP tears were sent to 20 orthopaedic sports medicine surgeons at various stages of training. Surgeons were asked to identify the type of SLAP tear using the Snyder and ESLAP classifications. Surgeons were then asked to determine the treatment for a SLAP tear using 4 clinical scenarios: (1) in the throwing arm of an 18-year-old pitcher; (2) in the dominant arm of an 18-year-old overhead athlete; (3) a 35-year-old overhead athlete; (4) or a 50-year-old overhead athlete. Responses were recorded, and the cases were shuffled and sent back 6 weeks after the initial responses. Results were then analyzed using the Fleiss kappa coefficient (κ) to determine interobserver and intraobserver degrees of agreement. Results: There was moderate intraobserver reliability in both the Snyder and ESLAP classifications (κ = 0.52) and fair interobserver reliability for both classification systems (Snyder, κ = 0.31; ESLAP, κ = 0.30; P < .0001) among all surgeons. Additionally, there was only fair agreement (κ = 0.30; P < .0001) for the treatment modalities chosen by the reviewers for each case. Conclusion: This study demonstrated that SLAP tears remain a challenging problem for orthopaedic surgeons in diagnostics and treatment plans. Therefore, care should be taken in the preoperative discussion with the patient to consider all the possible treatment options because this may affect the postoperative recovery period and patient expectations.
Spatial Distribution and Epidemiological Factors of Brucellosis in Ardabil Province, Iran
Authors: Jafarzadeh Mohammad , Habibzadeh Shahram , Moradi-Asl Eslam , Mohamadshahi Jafar , Abishvand Javad , Nakhostin Babak 
Published: November 2023

Introduction Brucellosis is one of the most prevalent infectious diseases in the world that infects humans directly through contaminated livestock or indirectly through animal products and induces high medical and economic damage annually. Objective Using geographic information system (GIS) software to determine the hot spots of brucellosis and the spatial correlation and type of disease distribution. Methods We extracted the incidence cases of the disease from 2016 to 2020 in this retrospective cross-sectional study using the disease registration system of Ardabil University of Medical Sciences. The interpolation method (IDW) was employed for spatial analysis and disease distribution and determination of hotspot points, Moran I and General G analysis were used to determine spatial autocorrelation at a significant level ( P < 0.05). GIS software 10.4.1 was applied to determine areas. Results 2679 cases of brucellosis were diagnosed in the province during the study that 96.97% were Iranian, 2.95% Azerbaijani, and 0.08% were Iraqi. 40.5% of patients were female and 59.5% were male. The highest number of infected cases was reported in 2020 with 29.2% and the lowest number was reported in 2016 with 16%. Rural areas had a high prevalence in terms of distribution and the north of Aslanduz and the central part of Sarein were determined as two significant rural areas of the disease. The trend of disease was increasing from east to west of the province. Conclusion Brucellosis is very widespread in rural areas in Ardabil Province. Ardabil University of Medical Sciences is required to take practical and educational measures to control this disease in high-risk centers. It is expected to take measures in order to educate villagers.
Faith, bordering and modern slavery: A UK case study
Authors: Waite Louise , Lewis Hannah , Murray Rebecca , Tomalin Emma 
Published: November 2023

In this paper we consider the imbrication of UK immigration and border controls into support environments of the anti-modern slavery sphere. We draw on the findings of a 3.5 years ESRC-funded study to explore how the increasingly strident government anti-migrant agenda - broadly seen in the ‘hostile environment’, a culture of disbelief and an overarching preeminence of border controls over human rights protections - is percolating into care providers in the modern slavery sector. Bordering in this sector has not had the same level of scrutiny as within the asylum sector, yet is a particularly interesting site to explore due to the confluence of caring and control impulses. The fresh insight we bring to this context is a focus on the notable presence of faith-based organisations in this sphere. We consider the implications of the relationships between faith, support and bordering - both for those subjected to immigration controls, and those working inextricably within them to support individuals exiting exploitation.
Understanding Barriers and Strategies to Accessing Healthy Food in Urban Agriculture for Community Residents in Predominantly Black Communities
Authors: Lofton Saria , Martin Akilah , Kersten Marjorie , Lubimbi Nanyombi , Vilme Helene , Avorgbedor Forgive , Odoms-Young Angela 
Published: November 2023

Background Some residents in predominantly Black communities face significant challenges in accessing healthy food. However, urban agriculture is a growing sector that aims to increase overall food production, access to affordable and nutritious produce, and potentially improve community food security. Purpose This study aimed to provide insight into barriers and strategies that urban agriculture growers and advocates identified for accessing urban agriculture markets in their communities. Research Design and Study Sample We interviewed and conducted focus groups with 17 urban growers and local food advocates that work in predominantly Black communities in Chicago. Data Collection and/or Analysis Understanding the complexities of access to healthy food can be challenging; therefore, we used the concept of access – accessibility, availability, affordability, accommodation, and acceptability – to better understand these barriers. Results Key barriers were the lack of accessibility to traditional food retailers, high availability of processed foods, and cultural acceptability of urban-produced foods. Conclusion Building urban agriculture networks to support growers, connect with consumers, and emphasize political engagement can help to diversify and grow urban agriculture.
Chromosome-level genome assembly of the deep-sea snail Phymorhynchus buccinoides provides insights into the adaptation to the cold seep habitat
Authors: Liu Zhaoqun , Huang Yuting , Chen Hao , Liu Chang , Wang Minxiao , Bian Chao , Wang Lingling , Song Linsheng 
Published: November 2023

Abstract
Background
The deep-sea snail Phymorhynchus buccinoides belongs to the genus Phymorhynchus (Neogastropoda: Raphitomidae), and it is a dominant specie in the cold seep habitat. As the environment of the cold seep is characterized by darkness, hypoxia and high concentrations of toxic substances such as hydrogen sulfide (H2S), exploration of the diverse fauna living around cold seeps will help to uncover the adaptive mechanisms to this unique habitat. In the present study, a chromosome-level genome of P. buccinoides was constructed and a series of genomic and transcriptomic analyses were conducted to explore its molecular adaptation mechanisms to the cold seep environments.

Results
The assembled genome size of the P. buccinoides was approximately 2.1 Gb, which is larger than most of the reported snail genomes, possibly due to the high proportion of repetitive elements. About 92.0% of the assembled base pairs of contigs were anchored to 34 pseudo‐chromosomes with a scaffold N50 size of 60.0 Mb. Compared with relative specie in the shallow water, the glutamate regulative and related genes were expanded in P. buccinoides, which contributes to the acclimation to hypoxia and coldness. Besides, the relatively high mRNA expression levels of the olfactory/chemosensory genes in osphradium indicate that P. buccinoides might have evolved a highly developed and sensitive olfactory organ for its orientation and predation. Moreover, the genome and transcriptome analyses demonstrate that P. buccinoides has evolved a sulfite-tolerance mechanism by performing H2S detoxification. Many genes involved in H2S detoxification were highly expressed in ctenidium and hepatopancreas, suggesting that these tissues might be critical for H2S detoxification and sulfite tolerance.

Conclusions
In summary, our report of this chromosome-level deep-sea snail genome provides a comprehensive genomic basis for the understanding of the adaptation strategy of P. buccinoides to the extreme environment at the deep-sea cold seeps.
Abstracts of randomized controlled trials in pediatric dentistry: reporting quality and spin
Authors: Guo Feiyang , Ye Wengwanyue , Qin Danchen , Fang Xiaolin , Hua Fang , He Hong 
Published: November 2023

Abstract
Background
Abstracts provide readers a concise and readily accessible information of the trials. However, poor reporting quality and spin (misrepresentation of research findings) can lead to an overestimation in trial validity. This methodological study aimed to assess the reporting quality and spin among randomized controlled trial (RCT) abstracts in pediatric dentistry.

Methods
We hand-searched RCTs in five leading pediatric dental journals between 2015 and 2021. Reporting quality in each abstract was assessed using the original 16-item CONSORT for abstracts checklist. Linear regression analyses were performed to identify factors associated with reporting quality. We evaluated the presence and characteristics of spin only in abstracts of parallel-group RCTs with nonsignificant primary outcomes according to pre-determined spin strategies.

Results
One hundred eighty-two abstracts were included in reporting quality evaluation. The mean overall quality score was 4.57 (SD, 0.103; 95% CI, 4.36–4.77; score range, 1–10). Only interventions, objective, and conclusions were adequately reported. Use of flow diagram (P < 0.001) was the only significant factor of higher reporting quality. Of the 51 RCT abstracts included for spin analysis, spin was identified in 40 abstracts (78.4%), among which 23 abstracts (45.1%) had spin in the Results section and 39 in the Conclusions Sect. (76.5%).

Conclusions
The reporting quality of RCT abstracts in pediatric dentistry is suboptimal and the prevalence of spin is high. Joint efforts are needed to improve reporting quality and minimize spin.
The associations of osteoporosis and possible sarcopenia with disability, nutrition, and cognition in community-dwelling older adults
Authors: Chou Yin-Yi , Lin Cheng-Fu , Lee Yu-Shan , Weng Shuo‑Chun , Kuo Fu-Hsuan , Hsu Chiann-Yi , Lin Shih-Yi 
Published: November 2023

Abstract
Background
Osteoporosis and sarcopenia, respectively, have detrimental impact on health, and combination of both conditions, termed osteosarcopenia, is becoming an increasingly important disorder in older adults as populations age. This study aimed to explore the relationship between osteoporosis and possible sarcopenia and their joint effect on physical performance, nutritional status, and cognition in community-dwelling older adults.

Methods
This study was conducted at a medical center in Taiwan, which included the adjacent community care station. The participants were recruited through regular activities at the community care station between January 01, 2015 and February 28, 2022. During the study period, dual-energy X-ray absorptiometry and comprehensive geriatric assessment consisting of comorbidity burden, functional status, cognition, mood, and nutritional status were performed during the study period. Possible sarcopenia was identified utilizing the criteria set by the Asian Working Group on Sarcopenia in 2019 using the criteria of low muscle strength alone, and osteoporosis was defined by the World Health Organization criteria. Accordingly, the study subjects were divided into four groups: normal, only osteoporosis, only possible sarcopenia, and possible osteosarcopenia.

Results
There were 337 participants (68.6% female) with a median age of 78.0 years (interquartile range: 71.0–85.0 y/o). According to the clinical definition of osteosarcopenia, 78 participants were normal, 69 participants showed possible sarcopenia, 61 participants had osteoporosis, and 129 had osteoporosis with possible sarcopenia. Among the four groups, the prevalence rates of chronic illness, functional capacity, physical performance, cognitive impairment, and malnutrition revealed statistically significant differences. Using logistic regression analysis after adjusting for the other covariates, osteoporosis with possible sarcopenia was associated with an increased odds ratio of cognitive impairment.

Conclusions
The findings suggest that compared to osteoporosis or possible sarcopenia alone, osteoporosis with possible sarcopenia was more likely to be associated with cognitive impairment. Early identification and targeted interventions for cognitive impairment in older adults with osteosarcopenia may be valuable in maintaining cognitive well-being and overall quality of life.
A comparative analysis of cycle threshold (Ct) values from Cobas4800 and AmpFire HPV assay for triage of women with positive hrHPV results
Authors: Zhang Yi , Zhang Wei , Du Hui , Qu Xinfeng , Chen Yun , Wang Jianliu , Wu Ruifang 
Published: November 2023

Abstract
Background
To compare the triage performance of HPV viral loads reflected by cycle threshold values (CtV) from two different HPV testing assays: the PCR based Cobas4800 and the isothermal amplification based AmpFire assay.

Methods
We used the data from a sub-study of The Chinese Multi-Center Screening Trial and analyzed the data of the cases positive in both Cobas4800 and AmpFire assays with recorded CtV. Spearman’s correlation was applied to analyze the association between CtV from AmpFire and Cobas4800 assays, as well as the correlation between CtV and the histological lesion grades. The 50th percentile of CtV was used as the cutoff to construct triage algorithms for HPV-positive cases. McNemar’s test was used to analyze the differences in sensitivity and specificity for detecting CIN2 + and CIN3 + in different triage algorithms.

Results
Four hundred forty-six HPV positive women who had consistent HPV results from Cobas4800 and AmpFire in terms of the HPV genotype and reported Ct values were included in the analysis. The mean CtV of hrHPV tested by Cobas4800 and AmpFire were linear correlated. Direct association were showed between the severity of cervical lesions and the HPV viral loads reflected by CtV of hrHPV, HPV16, non-16/18 hrHPV and A9 group from both assays. HPV16/18 genotyping combined with low-CtV for non-16/18 hrHPV, especially A9 group, were demonstrated to be satisfactory in the sensitivity and specificity for detecting CIN2 + or CIN3 + .

Conclusion
Ct value represented a good triage marker in both PCR-based and isothermal amplification HPV detection.