bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorescence spectroscopy based characterization of Flaxseed Oil
Authors: Saleem M. , Ahmad Naveed 
Published: January 2024

Abstract
Fluorescence spectroscopy has been employed for the compositional analysis of flaxseed oil, detection of its adulteration and investigation of the thermal effects on its molecular composition. Excitation wavelengths from 320 to 420 nm have been used to explore the valued ingredients in flaxseed oil. The emission spectra of flaxseed oil revealed that it contains high concentration of vitamin K, isomers of vitamin E, carotenoids and chlorophylls with corresponding emission spectra at 390, 414, 441, 475, 515 and 673/720 nm, which can be used as a marker for quality analysis. Detection of adulteration of canola oil in flaxseed oil has been demonstrated by applying principal component analysis. Moreover, the effects of temperature on the molecular composition of cold pressed flaxseed oil has been explored by heating them at cooking temperatures of 100, 110, 120, 130, 140, 150, 160, 170 and 180°C, each for 30 minutes. On heating, the deterioration of vitamin E, carotenoids and chlorophylls occurred with an increase in the oxidation products. However, it was found that up to 140°C, flaxseed oil retains much of its natural composition whereas up to 180 oC, it loses much of its valuable ingredients along with increase of oxidized products.
Genetic Insights and Therapeutic Potential for Colorectal cancer: Mutation Analysis of KRAS Gene and Efficacy of Oleuropein-Conjugated Iron Oxide Nanoparticles
Authors: Mehdinejad Sedigheh , Peymani Maryam , Salehzadeh Ali , Zaefizadeh Mohammad 
Published: January 2024

Abstract
This study aimed to address the challenges of treating advanced stages of colon cancer (CRC) by exploring potential therapeutic options. The research focused on the genetic aspects of CRC, specifically the mutation rate of the KRAS gene, along with other genes like TTN, APC, MUC16, and TP53, using the TCGA dataset. Additionally, the study investigated the efficacy of Oleuropein, a polyphenolic compound found in olives, in combating CRC by using iron oxide nanoparticles coated with glucose and conjugated with Oleuropein. The study characterized the physicochemical properties of the nanoparticles and the cytotoxic effects of the nanoparticles were evaluated on CRC and normal fibroblast cell lines, demonstrating significantly higher cytotoxicity against CRC cells compared to normal cells. Furthermore, the study analyzed gene expression changes using the GSE124627 dataset to understand the influence of KRAS alterations. It identified numerous upregulated and downregulated genes in KRAS-overexpressing samples, suggesting their involvement in critical cancer-related pathways. These findings suggest that KRAS-influenced genes could serve as potential therapeutic targets for CRC treatment. The study also examined the expression levels of identified genes in CRC samples compared to normal samples. Among the upregulated genes, 22 showed significant increases in cancer samples, while 14 downregulated genes exhibited decreased expression in both KRAS-influenced and cancer samples. Cox regression analysis identified specific upregulated genes, including ANKZF1, SNAI1, PPFIA4, SIX4, and NOTUM, associated with poor prognosis. Kaplan-Meier analysis further confirmed the correlation between increased expression of these genes and higher patient mortality rates. In conclusion, this study provided valuable insights into the genetic aspects of CRC and potential therapeutic strategies. The use of Oleuropein-conjugated iron oxide nanoparticles showed promising cytotoxic effects on colon cancer cells. These findings contribute to advancing our understanding of CRC and offer potential targets for further investigation and the development of novel therapeutic approaches.
Phosphate Uptake in PhoX: Molecular Mechanisms
Authors: General Ignacio , Saura Maria Luz Peres , Cajachagua Cindy Lee , Balan Andrea 
Published: January 2024

Abstract
PhoX is a high-affinity phosphate binding protein, present in Xanthomonas citri, a phytopathogen responsible for the citrus canker disease. Performing molecular dynamics simulations and different types of computational analyses, we study the molecular mechanisms at play in relation to phosphate binding, revealing the global functioning of the protein: PhoX naturally oscillates along its global normal modes, which allow it to explore both bound and unbound conformations, eventually attracting a nearby negative phosphate ion to the highly positive electrostatic potential on its surface, particularly close to the binding pocket. There, several hydrogen bonds are formed with the two main domains of the structure. Phosphate creates, in this way, a strong bridge that connects the domains, keeping itself between them, in a tight closed conformation, explaining its high binding affinity.
Comparison of the Inter-laminar Approach and Laminotomy Open Approach for Filum Terminale Lipoma: A Retrospective Analysis
Authors: Nawashiro Tomoki , Kurimoto Michihiro , Nagakura Masamune , Kato Mihoko , Aoki Kousuke , Saito Ryuta 
Published: January 2024

Abstract
Purpose
Filum terminale lipoma (FTL) causes spinal-cord tethering and is associated with tethered-cord syndrome, which is treated by dissection of the entrapment. The conventional treatment for FTL involves dissection of the spinal cord through a laminotomy open approach (LOA). However, in recent years, the interlaminar approach (ILA) has gained popularity as a minimally invasive surgery. This study compares the effectiveness of the minimally invasive ILA with the conventional LOA in treating FTL.
Methods
We retrospectively evaluated data on the ILA and LOA for FTL at our center. In total, 103 participants were enrolled, including 55 in the ILA group and 48 in the LOA group.
Results
The ILA required significantly less surgical time and resulted in less blood loss. The improvement rate of symptoms in symptomatic patients was 84%, and for urinary symptoms and abnormal urodynamic study findings, it was 77%. The postoperative maintenance rate for asymptomatic patients was 100%. Postoperative complications of ILA included delayed wound healing in two patients (3.6%).
Conclusion
Compared with LOA, ILA offers advantages in terms of shorter operative time and less blood loss, with no significant difference in long-term symptom-improvement rates between the groups.
Mid-infrared light reduces the nicotine content and detoxifies bidis for safer smoking
Authors: Thangaraju Umakanthan , Ponnusamy Madhumathi 
Published: January 2024

Abstract
Tobacco use is dangerous to health and the environment. Despite the numerous measures taken to combat the adverse effects of tobacco, fruitful results are yet to be achieved. Nicotine is the primary psychoactive (and highly addictive) chemical component in tobacco. This study aimed to lower the nicotine content and detoxify bidis (a more harmful tobacco product compared to cigarettes). We subjected the bidi packets to 2–6 µm mid-infrared (mid-IR) light generated by a specially designed pocket-sized atomizer. The smoke from such mid-IR-treated bidis blown over animate and inanimate objects was non-irritating and harmless. Spectroscopic studies revealed that the applied 2–6 µm mid-IR exerted molecular-level changes and resulted in chemical compound transformations, thus lowering the nicotine content in the bidis. Trials with smokers demonstrated that the mid-IR-treated bidis were more desirable to smoke and also retained smoking pleasure and satiety. Thus, the 2–6 µm mid-IR light can detoxify the bidis and represents a safer way for smoking than attempting complete cessation, which is highly challenging for smokers.
Ensemble Transformer for cross lingual semantic textual similarity
Authors: Piroozfar Poorya , Abdous Mohammad , Bidgoli Behrouz Minaei 
Published: January 2024

Abstract
Today, it is particularly important to recognize the semantic similarity between texts in different languages due to the emergence of new natural language processing models like ChatGPT and Bard. These models can provide more accurate and comprehensive answers to users' questions by identifying semantic similarity between two texts in different languages. Cross-lingual semantic similarity refers to the process of calculating similarity between two pieces of text in different languages. This paper aims to present an improved method for finding similarities between sentences in different languages. Some of the current methods create the same vector space to achieve this, while others use machine translation to translate the text into another language and then determine similarity between the two sentences using monolingual sentence similarity methods. The degree of similarity is expressed as a number between 0 and 5. Over the past few years, the progress in language models based on transformers has paved the way for improvements in detecting text similarity. This article discusses the utilization of ensemble models with transformers to determine the semantic similarity of sentences in Persian and English languages utilizing the Persian-English corpus. According to our findings, this ensemble approach has a correlation rate of 95.28% in detecting the extent of semantic similarity between cross-lingual sentences. These results indicate that our method surpasses previous techniques for discovering similarities between sentences in different languages.
Adoption and Use of Learning Management Systems Among Teachers and Students in Higher Educational Institutions in Greater Noida
Authors: Jarry Paul Dominic 
Published: January 2024

Abstract
This research investigates the adoption and usage patterns of learning management systems (LMSs) in private higher education institutions, namely,Sharda University and Galgotias University, in Greater Noida, India. This study, guided by the unified theory of acceptance and use of technology (UTAUT) model, employs a quantitative approach through surveys and statistical analyses. The data collected from 76 teachers and 106 students provideinsights into LMS adoption.
Among the students, there was a moderate level of acceptance of the LMS, with Google Classroom being the preferred platform. While social influence and facilitating conditions varied, perceived usefulness, ease of use, and behavioral intentions remained consistent across demographic factors. Among the teachers, a generally positive attitude toward LMS adoption was observed, with Google Classroom being the predominant attitude. Demographic factors, such as age, gender, and teaching experience, influence teachers' perceptions. Regression analysis revealed a significant relationship between perceived aspects and teachers' behavioral intentions, highlighting the importance of these factors in shaping attitudes toward LMS adoption.
In summary, the study provides valuable insights into LMS adoption dynamics in private higher education in Greater Noida. The findings have implications for educational institutions aiming to improve their digital infrastructure and promote effective LMS utilization, offering potential applications for policymakers, educators, and stakeholders to enhance decision-making and educational quality in the region. Top of Form
Calculating transmembrane voltage on the electric pulse-affected cell membrane: using molecular dynamics and finite element simulations
Authors: Mirshahi Salim , Vahedi Behzad , Yazdani Saeed Oraee , Golab Mahdi , Sazgarnia Ameneh 
Published: January 2024

Abstract

In this study, the induced transmembrane voltage (ITV) was investigated by finite element method (FEM) of a spherical-shaped MCF-7 cell. Current study demonstrates how the thin layer that makes up a cell membrane can be substituted as the boundary between extracellular and intracellular by a particular surface conductivity. Moreover, for varied applied electric fields, the distribution of ITV on the cell membrane and its maximum value were experimentally assessed. Pore formation in cell membrane subjected to an external electric field was numerically studied by Molecular Dynamics (MD) simulations of palmitoyloleoyl-phosphatidylcholine (POPC). The quantity of the electroporated cell surface area corresponds to the applied external electric field, and the dependency on electric field was calculated. As a result, when mentioned numerical methods were used for applying external electric field of 1500 V/cm to the cell suspension, the total cell surface area was electroporated 66% and 68% for MD and FEM.
Adaptive dynamic programming path tracking control of a tractor- trailer wheeled mobile robot
Authors: Ghasemzadeh Aliakbar , Amjadifard Roya , Keymasi-Khalaji Ali 
Published: January 2024

Abstract

Tractor-trailer wheeled mobile robots (TTWMRs) have complex nonlinear dynamics that make their precise trajectory tracking control challenging. This paper investigates an adaptive dynamic programming (ADP) approach using a critical neural network (NN) to address the tracking control for continuous-time TTWMR that is modeled in a suitable affine form. A critical NN approximates the optimal cost function and enables adaptive tuning of the control policy. Decoupled kinematic and dynamic ADP controllers are proposed for integrated path and velocity tracking. For this purpose, tracking error signals are defined for each control loop. Theoretical analysis proves closed-loop stability and convergence. Simulations demonstrate superior tracking performance compared to previous techniques, with lower errors and control efforts. This highlights the benefits of ADP for optimizing TTWMR control despite uncertainties. The adaptive optimal control enables promising capabilities for autonomous applications.
Industry 5.0 Safety and Health Employee Surveillance
Authors: Chandra B Ravi , Indu P , Hemalatha G , Lakshmi P Jhansi 
Published: January 2024

Abstract

Using NodeMCU ESP8266, a device called Heart Pulse and Temperature of the Body Monitoring can measure both heartbeat and body temperature. On the LCD that is attached to the sensor, the measurements in BPM (Beats Per Minute) will be shown. Along with BPM values, the body temperate will be shown on the serial monitor. With the advancement of technology, this project makes use of the NodeMCU ESP8266 can digitally detect both heart rate and body temperature. The key benefit of using NodeMCU ESP8266 is that it can affect the environment by driving electric motors, light bulbs, and other actuators while also detecting itself by gathering data from a variety of sensors. The board's microcontroller is programmed using the NodeMCU ESP8266 programming language. Body temperature is measured using the LM35. Body temperature is a crucial parameter for assessing and diagnosing human health. A heartbeat sensor was used to calculate the heart rate. One can test their mean arterial pressure (MAP) using this program and the Android will display their accurate body temperature. The device may measure physiological parameters, including heart rate.
Nonbacterial Thrombotic Endocarditis of mitral valve associated with a lymphoproliferative malignancy: Case Report and Literature Review
Authors: Duarte Fabiana , Barradas Maria Inês , Dias Ana Raquel , Faria Carlos , Machado Carina , Pavão Carolina 
Published: January 2024

Abstract

Non-bacterial thrombotic endocarditis (NBTE) is a rare condition marked by sterile vegetations on cardiac valves, often linked to rheumatologic diseases, autoimmune disorders, and advanced solid malignancies. It poses a high risk of systemic embolization, and treatment and prognosis depend on the underlying clinical condition. We present a case of a 57 years-old male who presented to the emergency department with a 5-day history of painful swollen fingers and color change episodes (from pallor to cyanosis). The patient also reported unintentional weight loss and weakness over two months. Physical examination revealed erythrocyanosis in the distal extremities, prompting consideration of secondary Raynaud syndrome. Despite medical therapy, progressive digital ischemia led to multiple finger amputations. Diagnostic work-up, including a transesophageal echocardiogram, identified an irregular hyperechogenic mass on the mitral valve (scallops A1/A2) without valve disfunction. A thoracic computed tomography scan showed an enlarged right paratracheal lymph node. Histopathological analysis from a transthoracic needle biopsy revealed diffuse large B-cell lymphoma. The patient underwent aggressive R-CHOP chemotherapy, achieving a favorable complete response. This is a particular case involving the occurrence of NBTE and Raynaud phenomenon as the initial paraneoplastic manifestations in a previously healthy young man. Reports of NBTE associated with lymphoproliferative conditions are quite rare, with fewer than ten cases described in the literature. To our knowledge, this is the first case of NBTE specifically associated with diffuse large B-cell lymphoma.
Unmanned Aerial System-Driven Data and Advanced Deep Learning Strategies for Elevating Weed Management in Agricuture
Authors: Srivast Dhiraj , Singh Vijay , Li Song , Kochersberger Kevin 
Published: January 2024

Abstract

In the United States, Palmer amaranth is a troublesome weed that competes with major crops, such as, soybean, and may lead to significant crop yield reduction if not managed properly. Integrated weed management practices using eco-friendly artificial intelligence based weeding robots and spot sprayers have been gaining popularity in agriculture. All of these robotic systems and weed recognition approaches, utilize a weed image database and a set of machine learning algorithms. This study investigates the performance of classification and object detection algorithms using unmanned aerial systems based red, green, and blue imageries acquired at different growth stages of soybean and Palmer amaranth. Vision transformer and EfficientnetB0 achieved test accuracies of 97.69% and 93.26% respectively, but Vision Transformer was 2.5-times slower than EfficientNetB0 on inference speed. Based on the tradeoff between speed and accuracy, experimentally it was observed that YOLOv6s is a suitable object detection model for real-time deployment with 82.6% mean average precision. Additionally, we present a self-supervised contrastive learning approach to label Palmer amaranth and soybean classes, achieving 98.5% test accuracy, demonstrating the potential for cost-efficient data acquisition and labeling to advance precision agriculture research.
An observational study to determine the optimal physical evaluation site for detecting anemia
Authors: Horibata Ken , Kondo Seigo , Hashimoto Shuji , Takemura Yousuke 
Published: January 2024

Abstract

Clinical pallor has traditionally served as a screening tool for anemia; however, its assessment is inherently subjective and lacks objectivity. Therefore, we investigate the correlation between skin and mucosal color, as measured by a spectrophotometer among 92 adult Japanese outpatients, and venous hemoglobin (Hb) values, to identify the optimal anatomical assessment site for detecting anemia. Color readings of the lower lip, lower palpebral conjunctiva, palm, nail bed, and inside of the upper arm were obtained using a spectrophotometer. Skin and mucosal color were quantified using the Lab* color scale. The color difference (ΔE*) was employed to evaluate the discriminability of anemia identification across different assessment sites. The a* values of the lip, palpebral conjunctiva, palm, and inside of the upper arm exhibited a positive correlation with Hb values and were significantly lower in the anemic group. The L* and b* values of across all sites showed no significant or less differences. While the ΔE* levels for the palpebral conjunctiva and lip were readily discernible by the human eye when comparing the normal and anemic groups, recognition at this level proved challenging for other sites. Consequently, reliance on these sites for anemia diagnosis may lead to potential oversight.
New dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand: Synthesis, characterization, DNA/BSA binding studies and anticancer activity
Authors: Radisavljević Snežana , Ćoćić Dušan , Petrović Biljana , Kellner Ina , Ivanović-Burmazović Ivana , Radenković Nikola , Nikodijević Danijela , Milutinović Milena 
Published: January 2024

Abstract
With the aim to reveal the antitumor drug which possesses improved activity compared with cisplatin, we synthesized the new dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand. Further, the newly synthesized complex was characterized by various techniques to confirm the structure. The stability of this complex in water and in PBS buffer was investigated by UV-Vis spectroscopy. DNA binding studies were examined by UV-Vis, fluorescence spectroscopy and viscosity measurements. The competitive studies with EB or HOE were done by fluorescence spectroscopy. The results showed that the dinuclear gold(III) complex interacts with calf-thymus DNA (CT-DNA) via covalently binding mode. Furthermore, the investigated complex shows high value of binding constants for the interaction with bovine serum albumin (BSA) as well as for the interactions in the presence of site markers (eosin Y or ibuprofen). Dinuclear gold(III) complex induced remarkable cytotoxicity on HCT116 and MDA-MB-231 cancer cell lines, 24 and 72 h after treatment. The complex also showed selectivity and induced significantly lower cytotoxic activity on healthy cells compared to cancers. In support of the antitumor activity of this complex, the proapoptotic activity (via increased caspase 9 activity) and low percentages of necrosis were observed. All experimentally obtained results were corroborated by molecular docking simulations.
Integrated acetabular prosthesis versus bone grafting in total hip arthroplasty for Crowe type II and III hip dysplasia: a retrospective case–control study
Authors: Cheng Liangliang , 刘 宇宸 , Wang Linbao , Ying Jiawei , Wang Fuyang , Li Junlei , Zhao De-Wei 
Published: January 2024

Abstract
Background
Many methods of acetabular reconstruction with total hip arthroplasty (THA) for Crowe type II and III adult developmental dysplasia of the hip (DDH) acetabular bone defect have been implemented clinically. However, there was no study comparing the results of integrated acetabular prosthesis (IAP) with bone grafting (BG).
Method
The clinical data of 45 patients with unilateral Crowe type II and III DDH who underwent THA were retrospectively analyzed. The patients were divided into two groups: 25 patients using 3D printed IAP (group A) and 20 patients using BG (group B). Clinical and radiographic outcomes were evaluated.
Results
There were no significant differences between the two groups in Harris hip score (HHS) (preoperative, 6 months postoperative and the last follow-up), leg length discrepancy (LLD), cup inclination, cup anteversion, vertical center of rotation (V-COR) and horizontal center of rotation (H-COR) and proportion of cup coverage (P > 0.05). The HHS in group A was higher than in group B at 1 and 3 months postoperative (P<0.05). The surgical time and time to full weight-bearing in group A was shorter than in group B (P<0.05). The blood loss in group A was less than in group B (P<0.05). No complications were observed in either group during the follow-up period.
Conclusion
IAP and BG have similar radiographic outcomes and long-term clinical efficacy in THA for Crowe type II and III DDH, but IAP technique has higher surgical safety and facilitates the recovery of hip joint function, which is worthy of clinical promotion.