bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive droop control strategy of parallel LLC converters
Authors: Tang Yu , Xu Hucheng , Pei Yushuo , Yao Fang , Ge Leijiao 
Published: October 2023

AbstractWhen the resonant converters are connected in parallel, the output current is unbalanced without additional current‐sharing measures due to differences in resonant component. In the input‐parallel output‐parallel resonant converter system, the output voltage accuracy of the converter under the traditional droop control is analyzed when the load changes. In this paper, an adaptive droop control is proposed, in which the droop coefficient is adaptively adjusted as the load changes. The control method proposed in this paper realizes the current sharing between the converters and solves the shortcomings of the output voltage changing under different loads in the conventional droop control. Taking two parallel LLC converters as an example, the control block diagram of the parallel control method for adaptive adjustment of the droop coefficient proposed in this paper is given, and the stability of the control loop is analyzed. Finally, two parallel prototypes of LLC converters with input 200 V/output 24 V input are built by digital control, and the experiment shows that the proposed control method improves the shortcomings of excessive output voltage droop caused by traditional droop control during dynamic load switching, which verifies the effectiveness of the method.
Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development
Authors: Li Ang , Li Fei , Song Wei , Lei Zi‐Li , Sha Qian‐Qian , Liu Shao‐Yuan , Zhou Chang‐Yin , Zhang Xue , Li Xiao‐Zhen , Schatten Heide , Zhang Teng , Sun Qing‐Yuan , Ou Xiang‐Hong 
Published: October 2023

AbstractObjectiveTo reveal whether gut microbiota and their metabolites are correlated with oocyte quality decline caused by circadian rhythm disruption, and to search possible approaches for improving oocyte quality.DesignA mouse model exposed to continuous light was established. The oocyte quality, embryonic development, microbial metabolites and gut microbiota were analyzed. Intragastric administration of microbial metabolites was conducted to confirm the relationship between gut microbiota and oocyte quality and embryonic development.ResultsFirstly, we found that oocyte quality and embryonic development decreased in mice exposed to continuous light. Through metabolomics profiling and 16S rDNA‐seq, we found that the intestinal absorption capacity of vitamin D was decreased due to significant decrease of bile acids such as lithocholic acid (LCA), which was significantly associated with increased abundance of Turicibacter. Subsequently, the concentrations of anti‐Mullerian hormone (AMH) hormone in blood and melatonin in follicular fluid were reduced, which is the main reason for the decline of oocyte quality and early embryonic development, and this was rescued by injection of vitamin D3 (VD3). Secondly, melatonin rescued oocyte quality and embryonic development by increasing the concentration of lithocholic acid and reducing the concentration of oxidative stress metabolites in the intestine. Thirdly, we found six metabolites that could rescue oocyte quality and early embryonic development, among which LCA of 30 mg/kg and NorDCA of 15 mg/kg had the best rescue effect.ConclusionThese findings confirm the link between ovarian function and gut microbiota regulation by microbial metabolites and have potential value for improving ovary function.
Enabling successful science‐policy knowledge exchange between marine biodiversity research and management: An Australian case study
Authors: Karcher Denis B. , Cvitanovic Christopher , Colvin Rebecca , van Putten Ingrid 
Published: October 2023

AbstractKnowledge exchange (KE) between research and decision‐making is increasingly demanded for tackling environmental challenges, yet there is still much to learn about how to enable that effectively. Here, we analyze a distributor of research funding (i.e., the Australian National Environmental Science Program Marine Biodiversity Hub (‘the hub’)) which actively coordinated KE between researchers and state‐ and Commonwealth Government end‐users. Through 30 in‐depth qualitative interviews with researchers, hub executives and end‐users we identify enablers of KE engagement, compare what researchers and decision‐makers found most important, and highlight what research programs and funding organizations can learn from this case study. Through an evolution of programs, the hub had a strong governance structure, co‐identified priority setting, and funding for emerging priorities. Additional enablers were a legacy of longstanding interpersonal working relationships, regular engagement, knowledge brokering roles, and the nationally trusted role of the hub. Researchers more so than end‐users found trust, the focus on clear end‐user needs as well as the hub's governance and progress‐monitoring key to success. End‐users more often indicated the early engagement, collaborative nature, and flexibility to adjust as important assets to effective interaction. Visions for future KE included better engagement of Traditional Owners, streamlining direct access to expertise, more accessible outputs, and earlier involvement of researchers in policy development. In sum, we find that time (e.g., pre‐story, early engagement) and boundary roles (e.g., knowledge brokering individuals, engaged research funders or coordinators) are key to success underlining that there are substantial components to KE success that can be nurtured and planned for.
Role of ejection fraction in patients at risk for advanced heart failure: insights from the HELP‐HF registry
Authors: Pagnesi Matteo , Lombardi Carlo Mario , Tedino Chiara , Chiarito Mauro , Stolfo Davide , Baldetti Luca , Adamo Marianna , Calì Filippo , Inciardi Riccardo Maria , Tomasoni Daniela , Loiacono Ferdinando , Maccallini Marta , Villaschi Alessandro , Gasparini Gaia , Montella Marco , Contessi Stefano , Cocianni Daniele , Perotto Maria , Barone Giuseppe , Merlo Marco , Cappelletti Alberto Maria , Sinagra Gianfranco , Pini Daniela , Metra Marco 
Published: October 2023

AbstractAimsPatients with heart failure (HF) with reduced ejection fraction (EF) (HFrEF), mildly reduced EF (HFmrEF), and preserved EF (HFpEF) may all progress to advanced HF, but the impact of EF in the advanced setting is not well established. Our aim was to assess the prognostic impact of EF in patients with at least one ‘I NEED HELP’ marker for advanced HF.Methods and resultsPatients with HF and at least one high‐risk ‘I NEED HELP’ criterion from four centres were included in this analysis. Outcomes were assessed in patients with HFrEF (EF ≤ 40%), HFmrEF (EF 41–49%), and HFpEF (EF ≥ 50%) and with EF analysed as a continuous variable. The prognostic impact of medical therapy for HF in patients with EF < 50% and EF > 50% was also evaluated. All‐cause death was the primary endpoint, and cardiovascular death was a secondary endpoint. Among 1149 patients enrolled [mean age 75.1 ± 11.5 years, 67.3% males, 67.6% hospitalized, median follow‐up 260 days (inter‐quartile range 105–390 days)], HFrEF, HFmrEF, and HFpEF were observed in 699 (60.8%), 122 (10.6%), and 328 (28.6%) patients, and 1 year mortality was 28.3%, 26.2%, and 20.1, respectively (log‐rank P = 0.036). As compared with HFrEF patients, HFpEF patients had a lower risk of all‐cause death [adjusted hazard ratio (HRadj) 0.67, 95% confidence interval (CI) 0.48–0.94, P = 0.022], whereas no difference was noted for HFmrEF patients. After multivariable adjustment, a lower risk of all‐cause death (HRadj for 5% increase 0.94, 95% CI 0.89–0.99, P = 0.017) and cardiovascular death (HRadj for 5% increase 0.94, 95% CI 0.88–1.00, P = 0.049) was observed at higher EF values. Beta‐blockers and renin–angiotensin system inhibitors or sacubitril/valsartan were associated with lower mortality in both EF < 50% and EF ≥ 50% groups.ConclusionsAmong patients with HF and at least one ‘I NEED HELP’ marker for advanced HF, left ventricular EF is still of prognostic value.
Caspian Tern Management to Increase Survival of Juvenile Salmonids in the Columbia River Basin: Progress and Adaptive Management Considerations
Authors: Collis Ken , Roby Daniel D , Evans Allen F , Lawes Timothy J , Lyons Donald E 
Published: October 2023

Abstract
Predation by Caspian terns Hydroprogne caspia is a factor limiting the recovery of some Endangered Species Act-listed populations of salmonids from the Columbia River basin, especially steelhead Oncorhynchus mykiss. This prompted the development and implementation of two separate management plans, one in the Columbia River estuary and the other in the Columbia Plateau region, to reduce the impact of Caspian tern predation on smolt survival. Caspian terns nesting at managed breeding colonies within the basin were relocated to alternative nesting islands created for terns outside the basin. Both plans were successful in significantly reducing smolt losses to Caspian terns nesting at managed sites; however, new developments have led to regression in smolt survival gains associated with tern management. Adaptive management to prevent terns at managed colonies from relocating to nest elsewhere in the basin and to improve nesting opportunities for Caspian terns outside the basin are needed to maximize the survival benefits to Endangered Species Act-listed salmonids from management. Adaptive management is also necessary to ensure the long-term viability of the Pacific Flyway population of Caspian terns, whose breeding population has declined by more than 50% since the two management plans were implemented.
Comorbid cerebral amyloid angiopathy in dementia and prodromal stages—Prevalence and effects on cognition
Authors: Haussmann Robert , Homeyer Patricia , Sauer Cathrin , Grey Arne , Krukowski Pawel , Brandt Moritz D. , Donix Markus , Linn Jennifer 
Published: October 2023

AbstractObjectivesTo determine the contribution of cerebral amyloid angiopathy to cognitive impairment in MCI and dementia.MethodsPatients with subjective memory impairment (SMI), amnestic and non‐amnestic mild cognitive impairment ((n)aMCI), Alzheimer's disease (AD), mixed and vascular dementia (MD/VD) from our memory clinic were included in this retrospective analysis. Patients underwent neuropsychological testing and cranial magnetic resonance imaging (MRI). Magnetic resonance imaging data sets were analyzed regarding the presence of CAA‐related MRI biomarkers to determine CAA prevalence. ANOVAs were used to investigate the contribution of CAA to cognitive impairment within diagnostic groups and to determine whether differences in cognitive test performance between the diagnostic groups are mediated by total CAA burden.Results475 patients (222 male, 253 female) with SMI (n = 47), naMCI (n = 41), aMCI (n = 189), early AD (n = 9), AD (n = 114), MD (n = 71) and VD (n = 4) were included. Mean age was 73.2 (9.9) years. CAA prevalence was 14.9% in SMI, 14.6% in naMCI, 24.3% in aMCI, 22.2% in early onset AD, 18.4% in late onset AD, 46.5% in MD and 25% in VD. Patients with possible and probable CAA were older than patients without CAA. In particular, diagnosis of aMCI, early onset AD, MD and VD showed high CAA prevalence. In AD but not in aMCI, CAA diagnosis significantly influenced test performance in the CERAD word list recall (F (1,78) = 4505; p = 0.037; partial eta‐square = 0.055). Differences in cognitive test performance between the diagnostic groups of naMCI, aMCI, AD and MD were mediated by total CAA burden within AAT simply nouns subtest (F (2,39) = 4059; p = 0.025; partial eta‐square = 0.172) and in CERAD verbal fluency test (F (3,129) = 3533; p = 0.017; partial eta‐square = 0.076).ConclusionThis retrospective analysis demonstrates high prevalence rates of CAA in cognitive diagnoses. Our data suggest that comorbid CAA independently impacts cognitive test performance in the course of AD with presumably stage‐dependent effects. Especially in patients with AD comorbid CAA additionally impairs memory function. Total CAA small vessel disease burden further modulates psychometric differences in cognitive test performance between diagnostic groups regarding word finding and word fluency capabilities.
Morphological connectivity differences in Alzheimer's disease correlate with gene transcription and cell‐type
Authors: Yu Huiying , Ding Yanhui , Wei Yongbin , Dyrba Martin , Wang Dong , Kang Xiaopeng , Xu Weizhi , Zhao Kun , Liu Yong ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: October 2023

AbstractAlzheimer's disease (AD) is one of the most prevalent forms of dementia in older individuals. Convergent evidence suggests structural connectome abnormalities in specific brain regions are linked to AD progression. The biological basis underpinnings of these connectome changes, however, have remained elusive. We utilized an individual regional mean connectivity strength (RMCS) derived from a regional radiomics similarity network to capture altered morphological connectivity in 1654 participants (605 normal controls, 766 mild cognitive impairment [MCI], and 283 AD). Then, we also explored the biological basis behind these morphological changes through gene enrichment analysis and cell‐specific analysis. We found that RMCS probes of the hippocampus and medial temporal lobe were significantly altered in AD and MCI, with these differences being spatially related to the expression of AD‐risk genes. In addition, gene enrichment analysis revealed that the modulation of chemical synaptic transmission is the most relevant biological process associated with the altered RMCS in AD. Notably, neuronal cells were found to be the most pertinent cells in the altered RMCS. Our findings shed light on understanding the biological basis of structural connectome changes in AD, which may ultimately lead to more effective diagnostic and therapeutic strategies for this devastating disease.
Hierarchical task analysis as a systems mapping tool in complex health care environments: Emergency department response to chemical, biological, radiological, and nuclear events
Authors: Razak Saydia , Hignett Sue , Barnes Jo , Hancox Graham 
Published: October 2023

AbstractThe emergency department (ED) is at the forefront of the chemical, biological, radiological, and nuclear (CBRN) response. This study adopted a multilevel systems approach using the human factors/ergonomics (HFE) method of hierarchical task analysis (HTA) with document analyses of CBRN plans to represent work‐as‐Imagined. Work‐as‐imagined was compared with data from semistructured interviews using prompt cards for CBRN scenarios (n = 57) representing work‐as‐done. The aim was to provide methodological evidence for the use of HTA with an empirical synthesis of the ED in response to CBRN events. HTA was the preferred systems mapping tool because it aligns with a systems thinking approach, allows multiple‐level comparisons, highlights variability, and has an established usability track record. This study demonstrates the usability of HTA in the context of the ED responding to a CBRN event. The findings for core CBRN concepts included (1) liaise and communicate, (2) isolate and contain, and (3) personal protective equipment.
Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta‐analysis
Authors: Song Yanju , Zou Xuelun , Zeng Yi , Zhang Le , Mao Xinfa 
Published: October 2023

AbstractBackgroundThe link between inflammatory bowel disease (IBD) and intracerebral hemorrhage (ICH) is still unclear.AimsWe conducted a Mendelian randomization research and meta‐analysis to explore the impact of IBD and its subtypes (Crohn's disease [CD], ulcerative colitis [UC]) on the risk of ICH.MethodsTwo large genome‐wide association analysis studies of International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) and International Stroke Genetics Consortium as exposure (IBD, UC, and CD) and outcome (ICH) in the initial stage. IBD, CD, UC GWAS data from the FinnGen consortium were adopted for the replication phase, and ultimately, the results of the initial stage and replication phase data were combined in a meta‐analysis to evaluate the causal association between IBD and its subtypes and the risk of ICH.ResultsIn the initial stage, we found that in the IVW (odds ratio [OR] = 0.83, 95% confidence interval [CI]: 0.71–0.96, p = .01), MR‐PRESSO (OR = 0.85, 95% CI: 0.75–0.97, p = .02) and MR.RAPS (OR = 0.86, 95% CI: 0.76–0.98, p = .02) method showed that UC is associated with the risk of ICH. The causal relationship between IBD, CD, and the risk of ICH cannot be found by the IVW method. IBD and its subtypes UC, CD, and risk of ICH cannot find the presence of heterogeneity and pleiotropy. In replication stage, IBD (OR = 0.74, 95% CI: 0.59–0.94, p = .0135) related to ICH, while the IVW approach did not establish a causal link in UC and CD. The meta‐analysis still indicated that UC (OR = 0.83, 95% CI: 0.72–0.93, p < .05) would lessen the risk of ICH while the causality between IBD, CD, and ICH was unable to be established.ConclusionUC was causally related to ICH, but IBD and CD are not associated with ICH. The precise pathophysiological mechanism needs to be thoroughly investigated in more detail.
A Quantitative Sequencing Method for 5‐Formylcytosine in RNA
Authors: Lyu Ruitu , Pajdzik Kinga , Sun Hui‐Lung , Zhang Linda , Zhang Li‐Sheng , Wu Tong , Yang Lei , Pan Tao , He Chuan , Dai Qing 
Published: October 2023

Abstract5‐Formylcytosine (f5C) modification is present in human mitochondrial methionine tRNA (mt‐tRNAMet) and cytosolic leucine tRNA (ct‐tRNALeu), with their formation mediated by NSUN3 and ALKBH1. f5C has also been detected in yeast mRNA and human tRNA, but its transcriptome‐wide distribution in mammals has not been studied. Here we report f5C‐seq, a quantitative sequencing method to map f5C transcriptome‐wide in HeLa and mouse embryonic stem cells (mESCs). We show that f5C in RNA can be reduced to dihydrouracil (DHU) by pic‐borane, and DHU can be exclusively read as T during reverse transcription (RT) reaction, allowing the detection and quantification of f5C sites by a unique C‐to‐T mutation signature. We validated f5C‐seq by identifying and quantifying the two known f5C sites in tRNA, in which the f5C modification fractions dropped significantly in ALKBH1‐depleted cells. By applying f5C‐seq to chromatin‐associated RNA (caRNA), we identified several highly modified f5C sites in HeLa and mouse embryonic stem cells (mESC).
A mixed‐methods study of the quality of parental support during adolescents' information‐related Internet use as a co‐construction process
Authors: Kurock Ricarda , Teichert Jeannine , Meister Dorothee M. , Gerhardts Lara , Buhl Heike M. , Bonanati Sabrina 
Published: October 2023

AbstractIntroductionIn Europe, most Internet searches for school‐related tasks are situated at home, where parents can support adolescents. Although the frequency (quantity) of parental support has already been analyzed, a research gap exists concerning the quality of parental support in adolescents' information‐related Internet use. The quality of parental support in the field of homework involvement is known to be a predictor of adolescents' learning motivation and academic achievement, often discussed with regard to self‐determination theory (SDT) in terms of autonomy support, structure, emotional support, and control. These categories were adapted in this study to analyze parents' support in adolescents' Internet searching activities.MethodsUsing a mixed‐methods approach, we combined quantitative questionnaires and qualitative observations to analyze joint information‐related Internet uses. Therefore, 243 parent–adolescent dyads were surveyed and six parent–adolescent dyads were observed by videography in 2019/2020 in Germany. The adolescents were 11 years old, on average.ResultsThe parents rated all qualities higher than the adolescents. Emotional support was rated highest by both groups, whereas structure was rated lowest. Adolescents' and parents' view on parental support differ. The qualitative study revealed parents' often interfering behavior, whereas emotional support was low. Further, the active role of adolescents was highlighted in both quantitative and qualitative data.ConclusionsBy combining quantitative and qualitative approaches, we demonstrated a fruitful application of SDT in analyzing the quality of parental support during adolescents' Internet searches at home and shed light on the co‐construction of joint Internet searches.
Carbon and nitrogen dynamics in agricultural soil after application of cattle manure and eastern redcedar wood chips
Authors: Olivo Agustin J. , Henning Eric , Schott Linda , Schmidt Amy Millmier 
Published: October 2023

AbstractUncontrolled proliferation of eastern redcedar tree (Juniperus virginiana) in the Midwest United States requires new alternatives for utilization of waste wood, such as mulching, that promotes efficient tree management by landowners. Similarly, efficient use of manure from animal feeding operations in cropping systems can reduce negative environmental impacts and increase cropland productivity. The objectives of this study were to quantify the nitrogen (N) and carbon (C) decomposition rates, availability, and effects on soil chemical properties of eastern redcedar wood chips (WC), cattle manure (CM), and the combination of cattle manure and wood chips (MW). A 120‐day incubation and a 12‐month field experiment were conducted in Nebraska. In the incubation study, CM decomposed the fastest, followed by MW and WC. At the end of the experiment, WC induced N immobilization. In the field experiment, most decomposition for all amendments occurred during the period between May and August (spring/summer). Decomposition was most rapid for CM and WC with 44% and 55% organic‐C loss by mass, respectively. Approximately, 40% of the organic N in CM mineralized during the 1‐year field study. Wood chips induced N immobilization after 6 months for shallow soil layers compared to control (no amendment) but did not induce N immobilization when combined with manure. Changes in soil organic matter concentration due to amendment application were not observed at any stages of the field experiment, likely due to the length of the experiment. However, consecutive applications of comingled MW may provide benefits of C contribution to the soil without inducing N limitations.
Uniformly 3‐connected graphs
Authors: Xu Liqiong 
Published: October 2023

AbstractLet be a positive integer. A graph is said to be uniformly ‐connected if between any pair of vertices the maximum number of independent paths is exactly . Dawes showed that all minimally 3‐connected graphs can be constructed from such that every graph in each intermediate step is also minimally 3‐connected. In this paper, we generalize Dawes' result to uniformly 3‐connected graphs. We give a constructive characterization of the class of uniformly 3‐connected graphs which differs from the characterization provided by Göring et al., where their characterization requires the set of all 3‐connected and 3‐regular graphs as a starting set, the new characterization requires only the graph . Eventually, we obtain a tight bound on the number of edges in uniformly 3‐connected graphs.