bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Cardiorespiratory Fitness and the Risk of Breast Cancer in Women
Authors: Katsaroli Ioanna , Sidossis Labros , Katsagoni Christina , Sui Xuemei , Cadenas-Sanchez Christina , Myers Jonathan , Faselis Charles , Murphy Rayelynn , Samuel Immanuel Babu Henry , Kokkinos Peter 
Published: January 2024

ABSTRACT

Introduction
Studies have shown an inverse association between the risk of breast cancer in women and physical activity. However, information on the association between cardiorespiratory fitness (CRF) assessed objectively by a standardized test and the risk of developing breast cancer is limited.

Purpose
To examine the CRF-breast cancer risk association in healthy females.

Methods
This retrospective study was derived from the ETHOS cohort (n = 750,302). Female participants (n = 44,463; mean age ± SD; 55.1 ± 8.9 years) who completed an exercise treadmill (ETT) test evaluation (Bruce protocol) at the Veterans Affairs (VA) Medical Centers nationwide from 1999 to 2020 were studied. The cohort was stratified into four age-specific CRF categories (Least-fit, Low-fit, Moderate-fit, and Fit), based on the peak metabolic equivalents (METs) achieved during the ETT.

Results
During 438,613 person-years of observation, 994 women developed breast cancer. After controlling for covariates, the risk of breast cancer was inversely related to exercise capacity. For each 1-MET increase in CRF the risk of cancer was 7% lower (HR 0.93; 95% CI, 0.90-0.95; P < .001). When risk was assessed across CRF categories with the Least-fit group as the referent, the risk was 18% lower for Low-fit women (HR 0.82; 95% CI, 0.70-0.96; P = .013), 31% for Moderate-fit (HR 0.69; 95% CI, 0.58-0.82; P < .001) and 40% for Fit (HR 0.60; 95% CI, 0.47-0.75; P < .001).

Conclusions
We observed an inverse and graded association between CRF and breast cancer risk in women. Thus, encouraging women to improve CRF may help attenuate the risk of developing breast cancer.
In-hospital onset of transient myoclonic state in older adults: a case report
Authors: Harada Taku , Yamasato Kazushi , Nakanishi Toshiyuki , Nakai Mori 
Published: January 2024

Background: Transient myoclonic (TM) state in older adults is a neurological condition characterised by short-lived, repetitive myoclonus without consciousness disturbance. First reported in 1992, it predominantly affects older individuals with chronic diseases. Despite its clear symptomatology, TM often remains under-recognised, leading to potential misdiagnoses. Case description: We report a case of a 68-year-old woman with a history of chronic heart failure who developed TM during hospitalisation following medication adjustment for acute heart failure. The patient, who had no history of intracranial disease or epilepsy, experienced acute involuntary movements of the face and limbs three days after diuretic adjustment. She responded well to intravenous diazepam and oral clonazepam, with no recurrence of symptoms post-treatment. Discussion: TM presents with bilateral, irregular, and repetitive myoclonus, mostly affecting the head, neck and upper extremities. Diagnosis is clinical, based on symptomatology and normal laboratory results. This case underscores the importance of recognising TM in differential diagnosis, especially in older patients in the acute or recovery phase of infection, or with medication changes. The potential role of fluid volume changes in TM pathophysiology in patients with underlying conditions such as hypertension or chronic heart failure is also highlighted. This case emphasises the need for heightened awareness and knowledge of TM among healthcare professionals. Conclusions: TM, though rare, requires awareness among clinicians for accurate diagnosis and management. It is crucial to avoid misdiagnosis and unnecessary interventions, and to provide appropriate information during care transitions, particularly in older adults with chronic conditions.
Identifying health-related quality of life concepts to inform the development of the WOUND-Q
Authors: Tsangaris Elena , van Haren Emiel LWG , Poulsen Lotte , Squitieri Lee , Hoogbergen Maarten M , Cross Karen , Sørensen Jens Ahm , van Alphen Tert C , Pusic Andrea , Klassen Anne F 
Published: January 2024

Objective: The impact of hard-to-heal wounds extends beyond traditional clinical metrics, negatively affecting a patient's health-related quality of life (HRQoL). Yet treatment outcomes are seldom measured from the patient's perspective. The purpose of the present study was to perform in-depth qualitative interviews with patients diagnosed with varying types of hard-to-heal wounds to identify outcomes important to them. Method: Participants were recruited from wound care clinics in Canada, Denmark, the Netherlands and the US, and were included if they had a hard-to-heal wound (i.e., lasting ≥3 months), were aged ≥18 years, and fluent in English, Dutch or Danish. Qualitative interviews took place between January 2016 and March 2017. An interpretive description qualitative approach guided the data analysis. Interviews were audio-recorded, transcribed and coded line-by-line. Codes were categorised into top-level domains and themes that formed the final conceptual framework. Results: We performed 60 in-depth interviews with patients with a range of wound types in different anatomic locations that had lasted from three months to 25 years. Participants described outcomes that related to three top-level domains and 13 major themes: wound (characteristics, healing); HRQoL (physical, psychological, social); and treatment (cleaning, compression stocking, debridement, dressing, hyperbaric oxygen, medication, suction device, surgery). Conclusion: The conceptual framework developed as part of this study represents the outcome domains that mattered the most to the patients with hard-to-heal wounds. Interview quotes were used to generate items that formed the WOUND-Q scales, a patient-reported outcome measure for patients with hard-to-heal wounds.
Effects of soft tissue mobilisation on subacute adherent linear scars: a single-group intervention study
Authors: Poddighe Diego , Ferriero Giorgio , Corna Stefano , Bravini Elisabetta , Sartorio Francesco , Vercelli Stefano 
Published: January 2024

Objective: Scar adherence due to a pathological healing process can cause physical and psychological disturbance. Soft tissue mobilisation (STM) techniques are widely used to treat and prevent scar adherence, but little is known on their effects. We aimed to analyse the effect of STM in patients with subacute post-surgical scar adhesions affecting the extremities. Method: A single-group quasi-experimental study was conducted on consecutive patients undergoing post-surgery limb rehabilitation. Patients with a baseline Adhesion Severity (AS) index of <0.5 at the worst scar point, as measured by the Adheremeter, were eligible. All patients who completed a minimum of five manual treatment sessions were included. The primary outcome was the AS index and the secondary outcome was the Italian version of the Patient and Observer Scar Assessment Scales (POSAS-I). Results: A cohort of 19 patients underwent an average of eight STM sessions over a period of one month. The AS index value increased from a median of 0.12 at baseline (interquartile range (IQR): 0.05–0.25) to 0.41 post-treatment (IQR: 0.26–0.63; median change: 0.24; IQR: 0.16–0.40; p<0.001). A large effect size was observed for both AS and Observer Scar Assessment Scale (OSAS-I) (Cohen r=0.6), with a large probability of superiority (PS) (87% and 86%, respectively). A moderate effect was observed for the Patient Scar Assessment Scale (PSAS-I) (Cohen=0.4; PS=71%). Pre–post treatment changes exceeded the minimal detectable changes for the AS and OSAS-I in 68% of subjects, and for PSAS-I in 21% of subjects. Conclusion: STM manual techniques may produce a large effect on the mobility of adherent subacute post-surgical scars.
Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer
Authors: Kwon Chae Hwa , Seo Hyung Il , Kim Dong Uk , Han Sung Yong , Kim Suk , Lee Nam Kyung , Hong Seung Baek , Ahn Ji Hyun , Park Young Mok , Noh Byeong Gwan 
Published: January 2024

BACKGROUND
Currently, there is no standard adjuvant therapy for patients with resected ampulla of Vater (AoV) cancer.
AIM
To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy (CCRT) in patients with advanced AoV cancer who underwent curative resection.
METHODS
This single-centered, retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and 2018. The impact of CCRT on advanced AoV cancer was analyzed.
RESULTS
The 1-, 3-, and 5-yr recurrence-free survival (RFS) rates for patients with advanced AoV cancer were 82.8%, 48.3%, and 40.8%, respectively, and the overall survival (OS) rates were 89.7%, 62.1%, and 51.7%, respectively. Lymphovascular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis, whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate analysis. Compared to the patients who did not receive adjuvant CCRT, those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS, although they had a significantly lower average age and significantly higher platelet-to-lymphocyte ratio.
CONCLUSION
Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV cancer. These findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.
Absence of enhancement in a lesion does not preclude primary central nervous system T-cell lymphoma: A case report
Authors: Kim Chan-Seop , Choi Chi-Hoon , Yi Kyung Sik , Kim Yook , Lee Jisun , Woo Chang Gok , Jeon Young Hun 
Published: January 2024

BACKGROUND
Primary central nervous system lymphoma (PCNSL) is a non-Hodgkin lymphoma that originates in the central nervous system (CNS) and is exclusively limited to the CNS. Although most PCNSLs are diffuse large B-cell lymphomas, primary CNS T-cell lymphomas (PCNSTLs) are rare. PCNSTLs typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging (MRI). To the best of our knowledge, non-enhancing PCNSTL has not been reported previously.
CASE SUMMARY
A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two weeks. Initial MRI showed asymmetric T2-hyperintense lesions within the brain. No enhancement was observed on the contrast-enhanced T1 image. The initial diagnosis was neuro-Behçet’s disease. Despite high-dose steroid therapy, no alterations in the lesions were identified on initial MRI. The patient’s symptoms deteriorated further. An MRI performed one month after the initial scan revealed an increased lesion extent. Subsequently, brain biopsy confirmed the diagnosis of PCNSTL. The patient underwent definitive combined chemo-radiotherapy. However, the patient developed bacteremia and died of septic shock approximately three months after diagnosis.
CONCLUSION
The absence of enhancement in the lesion did not rule out PCNSTL. A biopsy approach is advisable for pathological confirmation.
Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast: A case report
Authors: Akers Allison , Read Susan , Feldman John , Gooden Casey , English Diana P 
Published: January 2024

BACKGROUND
Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in literature. Breast metastases are associated with poor prognosis. The following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized treatment.
CASE SUMMARY
A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina, parametria and lymph node metastases. Cervical biopsies confirmed high grade adenocarcinoma with mucinous features. A positron emission tomography/computed tomography (PET/CT) did not show evidence of metastatic disease. She received concurrent cisplatin with external beam radiation therapy. Follow up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic disease. Patient was lost to follow up for six months. She was re-imaged on re-presentation and found to have widely metastatic disease including breast disease. Breast biopsy confirmed programmed death-ligand 1 positive metastatic cervical cancer. The patient received six cycles of carboplatin and paclitaxel with pembrolizumab. Restaging imaging demonstrated response. Patient continued on pembrolizumab with disease control.
CONCLUSION
Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis challenging. Clinical history and immunohistochemical evaluation of breast lesion, and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the breast. Overall, the prognosis is poor, but immunotherapy can be considered in select patients and may result in good disease response.
Subsequent bilateral acute carpal tunnel syndrome due to tophaceous infiltration: A case report
Authors: Yeoh Soon-Chin , Wu Wen-Tien , Shih Jui-Tien , Su Wen-Chin , Yeh Kuang-Ting 
Published: January 2024

BACKGROUND
Acute carpal tunnel syndrome (ACTS) is commonly caused by repetitive strain, trauma, or inflammatory conditions. However, ACTS due to tophaceous gout is a clinical event that remains poorly understood and underreported. This rare manifestation necessitates prompt diagnosis and intervention to prevent irreversible complications.
CASE SUMMARY
A 51-year-old man who had poorly controlled hyperuricemia presented with ACTS secondary to tophaceous gout. Because of rapid symptom progression symptoms and severe median nerve compression within 3 mo, the patient underwent emergency decompression surgery for both wrists at different time points. Postoperatively, he exhibited complete recovery of sensory and motor functions, with no recurrence at long-term follow-up. Favorable outcomes were achieved through immediate decompression surgery, anti-inflammatory medications, postoperative active and passive range-of-motion exercises, and intermittent wrist splinting. Prompt diagnosis and surgical intervention, when necessary, are crucial for preventing long-term complications and obtaining favorable outcomes in patients with ACTS. An optimal gout management strategy involving pharmacologic therapy and lifestyle modifications may help minimize ACTS recurrence and improve clinical outcomes.
CONCLUSION
Prompt surgical intervention and optimal gout management are crucial for preventing irreversible nerve damage and ACTS recurrence.
Significant improvement after sensory tricks and trunk strength training for Parkinson’s disease with antecollis and camptocormia: A case report
Authors: Wang Jia-Ren , Hu Yue 
Published: January 2024

BACKGROUND
Patients with Parkinson's disease (PD) exhibit symptoms such as antecollis (AC) and camptocormia (CC). The pathology of these two conditions is unclear. Additionally, standard treatment methods have not been established. The article reports the case of a 65-year-old female patient with AC and CC who was treated with central and peripheral interventions to alleviate symptoms.
CASE SUMMARY
We present the case of a 65-year-old female PD patient with AC and CC. The course of the disease was 5 years. She was treated with rehabilitation strategies such as sensory tricks and trunk strength training. During the inpatient period, we compared and analyzed the patient's gait, rehabilitation assessment scale score, and angles of her abnormal trunk posture in the first week, the third week, and the fifth week. The patient's stride length increased, indicating that the patient's walking ability was improved. The Unified Parkinson's Disease Scale Part Three score and CC severity score decreased. Furthermore, the score of the other scale increased. In addition, the patient showed significant improvements in AC, upper CC, and lower CC angles.
CONCLUSION
This case study suggested that sensory tricks and trunk strength training are beneficial and safe for patients with AC and CC.
It depends on you. Family beliefs of digital technologies as a regulator of children's screen use.
Authors: Grané Mariona , Suárez Rafael , Sabando Dorys 
Published: January 2024

Family attitudes and beliefs around digital technologies are a key factor in young children's digital habits in the home. This study involved conducting interviews with 46 families of children under 6 years of age to understand how parental perceptions determine the screen use of young children in terms of activities, content, and time. The aim is to provide knowledge for an in-depth reflection on media management in the home. A descriptive, quantitative study was designed, based on a questionnaire survey model to interview families. The results show few differences between the most positive and the most negative family perceptions of children's use of ICTs. The complexity of the analysis of parental digital education strategies and support systems is evident. The perceptions of families are based upon a balance that avoids extremes, are shrouded in contradictions, and are regulated according to the needs of the context. This leads to the need to consider, globally, the different factors that influence children's digital habits.
Impact of exercise training associated with enalapril treatment on blood pressure variability and renal dysfunctions in an experimental model of arterial hypertension and postmenopause
Authors: dos Santos Ferreira Silva Michel Pablo , Ferreira Maycon Junior , Shecaira Tânia Plens , da Silva Dias Danielle , Kimura Débora Conte , Irigoyen Maria Cláudia , Gomes Guiomar Nascimento , De Angelis Kátia 
Published: January 2024

Objective
In this study, we aimed to investigate the effects of the concurrent exercise training (CET) associated with the enalapril maleate on blood pressure variability (BPV) and renal profile in an experimental model of arterial hypertension (AH) and postmenopause.

Methods
Female ovariectomized spontaneously hypertensive rats (SHR) were distributed into 4 groups (n = 8/group): sedentary (SO), sedentary + enalapril (SOE), trained (TO) and trained + enalapril (TOE). Both enalapril (3mg/kg) and CET (3 days/week) were conducted during 8 weeks. Blood pressure (BP) was directly recorded for BPV analyses. Renal function, morphology, inflammation and oxidative stress were assessed.

Results
The SOE, TO e TOE groups presented decreased systolic BP compared with SO. Both trained groups (TO and TOE) presented lower BPV and increased baroreflex sensitivity (TO: 0.76 ± 0.20 and TOE: 1.02 ± 0.40 vs. SO: 0.40 ± 0.07 ms/mmHg) compared with SO group, with additional improvements in TOE group. Creatinine and IL-6 levels were reduced in SOE, TO and TOE compared with SO group, while IL-10 was increased only in TOE group (vs. SO). Enalapril combined with CET promote reduction in lipoperoxidation (TOE: 1.37 ± 0.26 vs. SO: 2.08 ± 0.48 and SOE: 1.84 ± 0.35 μmol/mg protein) and hydrogen peroxide (TOE: 1.89 ± 0.40 vs. SO: 3.70 ± 0.19 and SOE: 2.73 ± 0.70 μM), as well as increase in catalase activity (vs. sedentary groups). The tubulointerstitial injury was lower in interventions groups (SOE, TO and TOE vs. SO), with potentialized benefits in the trained groups.

Conclusions
Enalapril combined with CET attenuated BPV and baroreflex dysfunctions, probably impacting on end-organ damage, as demonstrated by attenuation in the AH-induced renal inflammations, oxidative stress and morphofunctional impairments in postmenopausal rats.
Unique case study: Impact of single‐session neuromuscular biofeedback on motor unit properties following 12 days of Achilles tendon surgical repair
Authors: De la Fuente Carlos , Silvestre Rony , Botello Julio , Neira Alejandro , Soldan Macarena , Carpes Felipe P. 
Published: January 2024

AbstractWe explored the first evidence of a single‐session neuromuscular biofeedback effect on motor unit properties, neuromuscular activation, and the Achilles tendon (AT) length 12 days after undergoing AT surgical repair. We hypothesized that immediate neuromuscular biofeedback enhances motor unit properties and activation without causing AT lengthening. After 12 days AT surgical repair, Medial Gastrocnemius (MG) motor unit decomposition was performed on a 58‐year‐old male before and after a neuromuscular biofeedback intervention (surface electromyography (sEMG) and ultrasonography), involving unressited plantar flexion. The analysis included motor unit population properties, sEMG amplitude, force paradigm, and AT length. There were increased MG motor unit recruitment, peak and average firing rate, coefficient of variation, and sEMG amplitude, and decreased recruitment and derecruitment threshold in the repaired AT limb. The non‐injured limb increased the motor unit recruitment, and decreased the coefficient of variation, peak and average firing rate, inter‐pulse interval, derecruitment threshold and sEMG amplitude. The AT length experienced −0.4 and 0.3 cm changes in the repaired AT and non‐injured limb, respectively. This single‐session neuromuscular biofeedback 12 days after AT surgery shows evidence of enhanced motor unit properties and activation without signs of AT lengthening when unresisted plantar flexion is performed in the repaired AT limb.
Role of social and psychological capital in successful nursing career progression: a structural equation modeling approach
Authors: Lv Huicong , Cui Yi , Wang Jing , Qi Weijing , Hu Jie 
Published: January 2024

Abstract

Objectives
Factors that influence career success play an important role in nurse’s professional development and clinical nursing management quality. However, limited studies have explored such factors from the perspective of social and psychological capital (PsyCap). This study explores the relationship between Leader–Member Exchange (LMX) and PsyCap and career success among Chinese clinical nurses.

Methods
A cross-sectional design with convenience sampling was employed. We recruited 1,221 nurses from two hospitals of Hebei Province, China. The average age of the participants was 30.94 years (SD=6.28; range, 19–56 years), and 95.6 % were female. The participants were surveyed using the Leader–Member Exchange Questionnaire, Psychological Capital Questionnaire, and Career Success Questionnaire. We used Student’s t-test, one-way analysis of variance, Pearson’s correlation analysis, and structural equation modeling to analyze the data.

Results
Career success was significantly correlated with LMX and PsyCap and its four dimensions: self-efficacy, hope, resilience, and optimism. LMX was significantly and positively correlated with PsyCap and its four dimensions. Furthermore, LMX positively predicted PsyCap, and PsyCap positively predicted career success. Moreover, PsyCap mediated the relationship between LMX and career success.

Conclusions
LMX (as social capital) and PsyCap influence the career success of Chinese clinical nurses.