bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of endovascular treatment after 6–24 h in ischaemic stroke patients with collateral flow on CT-angiography: A model-based economic evaluation of the MR CLEAN-LATE trial
Authors: Pinckaers Florentina ME , Evers Silvia MAA , Olthuis Susanne GH , Boogaarts Hieronymus D , Postma Alida A , van Oostenbrugge Robert J , van Zwam Wim H , Grutters Janneke PC 
Published: December 2023

Background: The MR CLEAN-LATE trial has shown that patient selection for endovascular treatment (EVT) in the late window (6–24 h after onset or last-seen-well) based on the presence of collateral flow on CT-angiography is safe and effective. We aimed to assess the cost-effectiveness of late-window collateral-based EVT-selection compared to best medical management (BMM) over a lifetime horizon (until 95 years of age). Materials and Methods: A model-based economic evaluation was performed from a societal perspective in The Netherlands. A decision tree was combined with a state-transition (Markov) model. Health states were defined by the modified Rankin Scale (mRS). Initial probabilities at 3-months post-stroke were based on MR CLEAN-LATE data. Transition probabilities were derived from previous literature. Information on short- and long-term resource use and utilities was obtained from a study using MR CLEAN-LATE and cross-sectional data. All costs are expressed in 2022 euros. Costs and quality-adjusted life years (QALYs) were discounted at a rate of 4% and 1.5%, respectively. The effect of parameter uncertainty was assessed using probabilistic sensitivity analysis (PSA). Results: On average, the EVT strategy cost €159,592 (95% CI: €140,830–€180,154) and generated 3.46 QALYs (95% CI: 3.04–3.90) per patient, whereas the costs and QALYs associated with BMM were €149,935 (95% CI: €130,841–€171,776) and 2.88 (95% CI: 2.48–3.29), respectively. The incremental cost-effectiveness ratio per QALY and the incremental net monetary benefit were €16,442 and €19,710, respectively. At a cost-effectiveness threshold of €50,000/QALY, EVT was cost-effective in 87% of replications. Discussion and Conclusion: Collateral-based selection for late-window EVT is likely cost-effective from a societal perspective in The Netherlands.
Trends in Gender of Authors of Patient Blood Management Publications
Authors: Forkin Katherine T. , Render Caroline M. , Staffa Steven J. , Goobie Susan M. 
Published: December 2023

BACKGROUND:
Diverse representation in the field of patient blood management (PBM) may help bring varying perspectives to improve patient care. We assessed trends in gender of first and last authorship of recent PBM publications to evaluate diversity within the field.

METHODS:
Publications from 10 high-impact anesthesiology and blood transfusion medicine journals between 2017 and 2021 were reviewed using 19 keywords to identify PBM-related articles. Each publication title was reviewed independently to determine whether it met the inclusion criteria. A software program was used to identify the gender of each first and last author for the most common first names. Author gender that could not be identified through this process was determined by querying institutional websites and professional social networks (eg, ResearchGate). Any publication where the gender of the first and/or last author could not be reliably determined was excluded from the analysis. Trends over time were assessed using the Cochran-Armitage test.

RESULTS:
A total of 2467 publications met the inclusion criteria of the 2873 yielded by the initial search. Gender of the first and last author was identified for 2384 of these publications and included in the final analysis. Approximately 42.8% of publications featured a woman as the first author with the highest from the journals such as the Journal of the American Medical Association (JAMA) (48.7%) and Transfusion (48.1%) and the lowest from the journals such as the British Journal of Anaesthesia (24.1%) and Anesthesia & Analgesia (24.4%). Approximately 32.0% of the publications featured a woman as the last author with the highest being Transfusion (36.9%) and Anaesthesia (31.8%) and the lowest being Anesthesia and Analgesia (18.3%) and Anesthesiology (18.6%). Approximately 57.6% of publications had either a woman as the first or last author while 16.3% of the publications had women as both the first and last authors. Women authors comprised 32.6% of the publications with a single author. Women as the first or last authors did not change significantly over the study period (P = .115 and P = .119, respectively). No significant difference was observed in the percentage of PBM articles with a woman as the first or last author, a woman as the first and last author, or a woman as a single author from 2017 to 2021 (P = .089, P = .055, and P = .226, respectively).

CONCLUSIONS:
The percentage of women as the first and last authors in PBM publications from the 5-year period of 2017 to 2021 was <50%. Gender equity in PBM authorship was identified as an area for potential future improvement. International mentorship and sponsorship of women remain important in promoting gender equity in PBM authorship.
National Sovereignty and the Postcolonial Bildungsroman
Authors: Srikanth Siddharth 
Published: December 2023

AbstractRecent scholarship on the bildungsroman highlights the ideological implications of bildung in relation to empire and human rights discourse. This essay adds to that scholarship by reading the postcolonial bildungsroman as an expression of the erosion of national sovereignty after decolonization. Bildung in post-SAP (Structural Adjustment Program) novels is contested because the development of a fully modern personality—rational, cosmopolitan, economically agentive, entrepreneurial, nonadversarial—privileged by modernization theory and global institutions symbolically undermines the political sovereignty promised by decolonization. Through an analysis of Pankaj Mishra's The Romantics, this essay argues that such contestation of bildung in post-SAP postcolonial bildungsromans generates narratives of negation in which the imagining of bildung is always deferred to imaginative and political futures. In The Romantics, bildung turns into an enduring historical trauma; Mishra juxtaposes various trajectories of individual and national growth both before and after India's adoption of SAP policies in 1991 to show how the symbolic realization of full and free personality development would paradoxically negate the claims to sovereignty that elevate such personality development as an expression of successful modernization. In The Romantics, as in Chimamanda Adichie's Purple Hibiscus and Mohsin Hamid's How to Get Filthy Rich in Rising Asia, the negation of successful bildung—and the deferral of fully formed visions of “development”—become the only registers in which to register liberatory growth in the peripheries of the capitalist world-economy.
Current Debates about the Colonial Economy and Government from the Spanish Royal Treasury Records
Authors: Klein Herbert S. 
Published: December 2023

Abstract
This essay surveys both the traditional findings and new debates that have used the Spanish imperial royal financial accounts to analyze the colonial economy and government. The crisis of the seventeenth century, the relations between colonial elites and royal government, the impact of income transfers among treasury offices, the sale of offices, the system of voluntary loans, the eighteenth-century reforms, and the influence of the tax system on the evolution of the colonial economy and society have all created a new set of questions and debates that historians, economists, and political scientists have engaged in. There is both consensus and disagreement on what these numbers mean for various groups in the society as well as long-term institutional developments. Just as new approaches have opened up new area for research, there are also a great deal of unexplored topics that can be developed using the unpublished primary accounts.
Planning in the Shadow of China
Authors: Ajl Max 
Published: December 2023

Abstract
This article considers the influence of Maoist China on Tunisian development theory in the late 1950s and early 1960s. The shadow—or brilliant light—of the Chinese experience was evident in Tunisia by the late 1950s, where wide-scale agrarian reform within the People's Republic and the use of cooperatives and labor-intensive agricultural technologies to rationalize the use and allocation of labor were immensely impacting foreign technical attaches, young Tunisian economists and agronomists, and people at the periphery of state planning and within the state-funded university system and research centers. In reading these proposals against the grain, this article situates them in their social and political context and the constraints that context imposed: a hewing away from outright enthusiasm for Communist China within the state-funded research centers, and a warmer embrace within more independent fora. It also situates those discussions amid a Tunisian milieu wherein China was increasingly embraced for its support of Algerian national liberation, its own national liberation war, with its experience seen as a third way for the Third World against the industrial-heavy experience of the USSR.
Introduction
Authors: Bsheer Rosie , Alsudairi Mohammed 
Published: December 2023

AbstractThis introduction to the special section “Inter-Asian Cold War Linkages” shows how an interdisciplinary group of ten scholars take up the understudied Cold War linkages between the Middle East, on the one hand, and East and South Asia on the other. They examine how the inter-Asian lens allows us to rethink the history of the twentieth-century Middle East. Central to such rethinking is the destabilization of some of the dichotomous categories that were normalized during the Cold War and that have greatly shaped how we view culture, economy, politics, and society. These include the categories of state/nonstate, national/transnational, revolution/counterrevolution, religion/secularism, and private/public. Instead of taking these dualities for granted, the scholars here foreground the blurred and dialectical relationship between them, utilizing the Middle East as a site of critical analysis, learning, and theorizing and putting its study in conversation with the more Asia-centric and transnationally attuned literatures of the global Cold War.4 In the process, alternative genealogies and relationalities of the Middle East emerge, ones that place the Middle East in the world rather than prioritize how “the world” has acted on the Middle East, usually as a periphery or site of intervention. Doing so brings into view new ways, periodizations, and scales of studying the global Middle East in general and the Cold War in particular.
Amanita Mushroom Toxin Poisoning in Los Angeles County
Authors: Jobin Parker G. , Stewart Connor , Vipani Aarshi , Perez-Alvarez Ingrid , Pepkowitz Samuel , Klapper Ellen , Berg Anders , Stillman Kaytlena , Torbati Sam , Kuo Alexander , Trivedi Hirsh , Yang Ju Dong , Steinberger Jonathan , Van Allan Richard J. , Friedman Oren , Cardoza Kathryn , Ayoub Walid S. 
Published: December 2023

ABSTRACTMushroom (amatoxin) poisoning from ingestion is a rare but life-threatening medical emergency characterized by gastrointestinal symptoms before progression to multisystem organ failure in severe cases. Many therapies of amatoxin intoxication have been described, including supportive care, medical therapies, detoxification strategies, and liver transplant. The evidence supporting these therapies remains limited due to the rarity of amatoxin poisoning and challenge of a timely diagnosis. We report a case of amatoxin poisoning in Los Angeles causing severe liver injury without acute liver failure treated successfully using medical therapies, gallbladder drainage, and plasma exchange.
Development and evaluation of a CRISPR-Cas13a system-based diagnostic for hepatitis E virus
Authors: Li Manyu , He Qiyu , Li Tingting , Wan Wenjun , Zhou Haiwei 
Published: December 2023

Abstract

Objectives
Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide. HEV RNA detection is the gold standard for HEV infection diagnosis and PCR methods are commonly used but are usually time-consuming and expensive, resulting in low detection efficiency and coverage, especially in low-income areas. Here, we developed a simpler and more accessible HEV RNA detection method based on CRISPR-Cas13a system.

Methods
A total of 265 samples of different types and sources, including 89 positive samples and 176 negative samples, were enrolled for evaluations. The sensitivity and specificity of the Cas13a-crRNA detection system were evaluated. The World Health Organization reference panel for HEV genotypes was used to evaluate the capability for detecting different HEV genotypes. The validity of the assay was compared with RT-qPCR.

Results
The 95 % limits of detection (LOD) of Cas13a-crRNA-based fluorescence assay and strip assay were 12.5 and 200 IU/mL, respectively. They did not show cross-reactivity with samples positive for hepatitis A virus, hepatitis B virus, hepatitis C virus, coxsackievirus A16, rotavirus, enterovirus 71, norovirus or enteropathic Escherichia coli. Different HEV genotypes (HEV1–4) can be detected by the assay. Compared to RT-qPCR, the positive predictive agreements of Cas13a-crRNA-based fluorescence and strip assay were 98.9 % (95 % CI: 93.9–99.8 %) and 91.0 % (95 % CI: 83.3–95.4 %), respectively. The negative predictive agreements were both 100 % (95 % CI: 97.8–100 %).

Conclusions
In conclusion, we established a rapid and convenient HEV RNA detection method with good sensitivity and specificity based on CRISPR-Cas13a system, providing a new option for HEV infection diagnosis.
Pre-analytical errors in coagulation testing: a case series
Authors: Mahto Mala , Kumar Visesh , Banerjee Ayan , Kumar Sushil , Kumar Anurag 
Published: December 2023

Abstract

Objectives
Prevention of pre-analytical issues in coagulation testing is of paramount importance for good laboratory performance. In addition to common issues like hemolysed, icteric, or lipemic samples, some specific pre-analytical errors of coagulation testing include clotted specimens, improper blood-to-anticoagulant ratio, contamination with other anticoagulants, etc. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are very commonly affected tests due to pre-analytical variables. The impact these parameters possess on surgical decision-making and various life-saving interventions are substantial therefore we cannot afford laxity and casual mistakes in carrying out these critical investigations at all.

Case presentation
In this case series, a total of 4 cases of unexpectedly deranged coagulation profiles have been described which were reported incorrectly due to the overall casual approach towards these critical investigations. We have also mentioned how the treating clinician and lab physician retrospectively accessed relevant information in the nick of time to bring back reassurance.

Conclusions
Like every other critical investigation, analytical errors can occur in coagulation parameters due to various avoidable pre-analytical variables. The release of spurious results for coagulation parameters sets alarm bells ringing causing much agony to the treating doctor and patient. Only a disciplined and careful approach taken by hospital and lab staff towards each sample regardless of its criticality can negate these stressful errors to a large extent.
Effect of daily zinc supplementation for 12 weeks on serum thyroid auto-antibody levels in children and adolescents with autoimmune thyroiditis – a randomized controlled trial
Authors: Sivakumar Ramachandran (Ramge) , Chinnaiah Govindareddy Delhikumar , Sahoo Jayaprakash , Bobby Zachariah , Chinnakali Palanivel 
Published: December 2023

Abstract

Objectives
To assess the effect of daily zinc supplementation for 12 weeks on thyroid auto-antibodies – thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), and oxidative stress in children with autoimmune thyroid disease (AITD) compared to standard therapy.

Methods
This open-labeled, parallel, randomized controlled trial was done in a tertiary care teaching institute in south India. Children aged 3–18 years with AITD were randomized to receive 25 mg elemental zinc daily for 12 weeks or standard therapy alone. The change in thyroid function tests (thyroid stimulating hormone, free T3, free T4), thyroid auto-antibody (TPOAb, TgAb) titers, oxidative stress markers (glutathione peroxidase, malondialdehyde, superoxide dismutase, and total antioxidant capacity) were compared.

Results
Forty children, 20 in each arm, were recruited in the study. We observed a female-to-male ratio of 7:1. Median duration of disease was 2 (0.25, 4.25) years. A total of 37 (92.5 %) children were hypothyroid, two hyperthyroid, and one euthyroid at enrolment. A total of 13 children (32.5 %) had associated co-morbidities, most commonly type 1 diabetes mellitus and systemic lupus erythematosus, three (7.5 %) each. We did not find any significant change in thyroid function tests, thyroid auto-antibody titers, and oxidative stress markers. However, the requirement of levothyroxine dose was significantly increased in the control arm, compared to the zinc group (p=0.03). Only four (20 %) children had minor adverse effects like nausea, metallic taste, and body ache.

Conclusions
Zinc supplementation did not have any effect on thyroid auto-antibodies and oxidative stress. Zinc-supplemented children did not require escalation in levothyroxine dose.
Attentional Focus Effects on Lower-Limb Muscular Strength in Athletes: A Systematic Review
Authors: Pompa Dario , Carson Howie J. , Beato Marco , di Fronso Selenia , Bertollo Maurizio 
Published: December 2023

AbstractPompa, D, Carson, HJ, Beato, M, di Fronso, S, and Bertollo, M. Attentional focus effects on lower-limb muscular strength in athletes: A systematic review.J Strength Cond Res38(2): 419–434, 2024—Evidence links an athlete's focus of attention to enhancing strength performance. However, additional research is needed to investigate the applicability of studies beyond the tasks and population currently examined. Therefore, we aimed to systematically review studies concerning attentional focus effects on strength characteristics on lower-limb tasks in athletes. Scopus, Web of Science, and EBSCO databases were searched using PRISMA PERSIST guidelines and keywords related to the focus of attention, force production processes, and athletes. Subjects were categorized: world class (tier 5); elite (tier 4); highly trained (tier 3); trained/developmental (tier 2); nonathletes (tiers 1–0); and mixed (different levels). Fifteen of 296 studies met the inclusion criteria. Included studies investigated the focus of attention effects on performance (n= 6), between skill levels (n= 2), and for learning (n= 5), with respect to subject preference (n= 1); one study did not state the aim. Studies achieved an average risk of bias score of “excellent”; however, findings suffered in the assessment of certainty. Only 2 studies reported an advantage for one type of attentional focus (external focus) across conditions (g= 0.13–0.42) with tier 2 and mixed tier athletes. Research does not address the needs of elite athletes, and there is limited evidence on each type of strength characteristics and muscle action. There is also a need to incorporate methodological steps to promote task-relevant instructions. Research should focus on contextualized information within professional practice to offer stronger translational implications for athletes and coaches.
Infection Associated With Invasive Devices in Pediatric Health Care: A Meta-analysis
Authors: Takashima Mari , Hyun Areum , Xu Grace , Lions Adriana , Gibson Victoria , Cruickshank Marilyn , Ullman Amanda 
Published: December 2023

CONTEXT
Indwelling invasive devices inserted into the body for extended are associated with infections.

OBJECTIVE
This study aimed to estimate infection proportion and rates associated with invasive devices in pediatric healthcare.

DATA SOURCES
Medline, CINAHL, Embase, Web of Science, Scopus, Cochrane CENTRAL, clinical trial registries, and unpublished study databases were searched.

STUDY SELECTION
Cohort studies and trials published from January 2011 to June 2022, including (1) indwelling invasive devices, (2) pediatric participants admitted to a hospital, (3) postinsertion infection complications, and (4) published in English, were included.

DATA EXTRACTION
Meta-analysis of observational studies in epidemiology guidelines for abstracting and assessing data quality and validity were used.

MAIN OUTCOMES AND MEASURES
Device local, organ, and bloodstream infection (BSIs) pooled proportion and incidence rate (IR) per-1000-device-days per device type were reported.

RESULTS
A total of 116 studies (61 554 devices and 3 632 364 device-days) were included. The highest number of studies were central venous access devices associated BSI (CVAD-BSI), which had a pooled proportion of 8% (95% confidence interval [CI], 6–11; 50 studies) and IR of 0.96 per-1000-device-days (95% CI, 0.78–1.14). This was followed by ventilator-associated pneumonia in respiratory devices, which was 19% (95% CI, 14–24) and IR of 14.08 per-1000-device-days (95%CI, 10.57–17.58).

CONCLUSIONS
Although CVAD-BSI and ventilator associated pneumonia are well-documented, there is a scarcity of reporting on tissue and local organ infections. Standard guidelines and compliance initiatives similar to those dedicated to CVADs should be implemented in other devices in the future.
ТЕРМІЧНИЙ АНАЛІЗ БІОМАСИ ХЛОРОФІЛСИНТЕЗУЮЧИХ МІКРОВОДОРОСТЕЙ CHLORELLA VULGARIS
Authors: Дячок Василь Володимирович , Кочубей Вікторія Віталіївна 
Published: December 2023

B роботі представлено результати досліджень щодо можливостей використання біопалива на основі біомаси хлорофілсинтезуючих мікроводоростей як сировини для карбонізації з одночасним зменшення вуглецевого сліду (пов’язаних з біо-CCU). Переробка біомаси мікроводоростей у біовугілля знаходить застосування для секвестрації вуглецю, сировини для виробництва теплової енергії, а також активованого вугілля для адсорбції токсичних сполук із забрудненого повітря, води та ґрунту. Біопаливо вважається вуглецево-нейтральним, оскільки CO2, що виділяється після їх спалювання, використовується рослинами та водоростями для фотосинтезу, що призводить до фіксації вуглекислого газу. Отримання енергії за рахунок спалювання карбонізованої біомаси мікроводоростей базується на ефекті нейтралізації вуглекислого газу, що суттєво відрізняє цей спосіб від відомих традиційних методів, і не спричиняє забруднення навколишнього середовища парниковими газами. Результати комплексного термогравіметричного та диференційного термічного аналізів теплотвірної здатності біовугілля на основі біомаси хлорофілсинтезуючих мікроводоростей Chlorella vulgaris отриманої в результаті сорбції парникових газів, утворених при спалюванні твердого, рідкого чи газоподібного палива засвідчують преспективність розвитку цього напрямку. Встановлено, що біомаса мікроводоростей, отримана при поглинанні діоксиду карбону – продукту спалюванння палива із домішками діосиду сульфуру, має більшу теплотвірну здатність у порівнянні із біомасою, отриманою при поглинанні чистого діоксиду карбону. Горіння біомаси мікроводоростей, яка містять у внутрішньому об’ємі клітин сполуки сульфуру, які утворюються внаслідок метаболізму діоксиду сульфуру, супроводжується більш значними екзотермічними ефектами. За результатами термічних досліджень було встановлено, що теплотвірна здатність такої біомаси мікроводоростів перевищує теплотвірну здатність осики, яка є альтернативним джерелом енергії на теренах України, та близькою до теплотвірної здатності селективно виведеної енергетичної верби Energetic willow (Salix Viminalis).