bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic profiling of serum exosomes reveals acute phase response and promotion of inflammatory and platelet activation pathways in patients with heat stroke
Authors: Li Yue , Li Huan , Ma Wenjuan , Maegele Marc , Tang Youqing , Gu Zhengtao 
Published: December 2023

Background: The pathological mechanism of heat stroke (HS) involves the acute phase response, unbalanced immunological/inflammatory reactions, and coagulation initiation, especially platelet activation. Although exosomes contain proteins involved in these biological processes, their protein cargo levels and potential roles in HS remain unknown. This study explored the serum exosome protein expression patterns after HS and their potential roles in the pathogenesis of HS.
Methods: Blood samples were collected from ten patients diagnosed with HS upon admission to the intensive care unit (six with severe HS and four with mild HS). Samples from six healthy volunteers were included as control. Using ultracentrifugation, exosomes were prudently isolated, and their protein contents were profiled using liquid chromatography–tandem mass spectrometry analysis with isobaric tags for relative and absolute quantification-based proteomics.
Results: Compared with healthy volunteers, patients with HS showed significant changes in the levels of 33 exosomal proteins (23 upregulated and 10 downregulated). The most upregulated proteins included serum amyloid A-1 (SAA-1), von Willebrand factor (vWF), S100A8, and histone H3. In addition, SAA-1, vWF, platelet membrane glycoprotein, S100A8, and histone H3 were more enriched in the exosomes from patients with severe HS than from those with mild HS. Gene ontology analysis revealed that the HS-modulated exosomal proteins were mostly related to inflammatory response, including the acute-phase response, platelet activation/degranulation, and innate immune response. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed significant enrichment of proteins in the IL-17 signaling pathway, platelet activation, neutrophil extracellular trap formation, Fc epsilon RI signaling pathway, chemokine signaling pathway, and NOD-like receptor signaling pathway, among others. Several serum exosomal proteins, including SAA-1, vWF, and S100A8, which are related to the acute phase, inflammatory response, and platelet activation, were confirmed to be elevated in patients with HS, and were significantly correlated with disease severity, organ dysfunction, and death.
Conclusion: Overall, this study explores the potential role of the serum exosomal proteome in the inflammatory response and platelet activation in HS, suggests the pathological mechanisms underlying HS-induced injuries, and recommends reliable exosomal biomarkers for predicting HS prognosis.
Optimizing the Electron Spin States of Na4Fe3(PO4)2P2O7 Cathodes via Mn/F Dual‐Doping for Enhanced Sodium Storage
Authors: Xi Yukun , Wang Xiaoxue , Wang Hui , Wang Mingjun , Wang Guangjin , Peng Junqi , Hou Ningjing , Huang Xing , Cao Yanyan , Yang Zihao , Liu Dongzhu , Pu Xiaohua , Cao Guiqiang , Duan Ruixian , Li Wenbin , Wang Jingjing , Zhang Kun , Xu Kaihua , Zhang Jiujun , Li Xifei 
Published: December 2023

AbstractA NASICON‐type Mn/F dual‐doping Na4Fe3(PO4)2P2O7 cathode material is successfully synthesized via a spray drying method. A medium‐spin of Fe is measured by DFT calculation, X‐ray absorption near edge structure (XANES), temperature‐dependent magnetization susceptibility (M−T) measurement, and electron paramagnetic resonance (EPR) tests. It indicates that the eg orbital occupation of Fe2+ can be finely regulated, thus optimizing the bond strength between the oxidation and reduction processes. Furthermore, from UV−vis DRS and four‐point probe conductivity measurements, it can be seen that, after adjusting the electron spin states, the band gap of the material has decreased from 1.01 to 0.80 eV, and the electronic conductivity has increased from 8.5 to 24.4 µS cm−1, thereby leading to competitive electrochemical performance. The as‐optimized Na4Fe3(PO4)2P2O7 displays both excellent rate performance (121.0 and 104.9 mAh g−1 at 0.1 C and 5 C, respectively) and outstanding cycling stability (88.5% capacity retention after 1000 cycles at 1 C). The results indicate that this low‐cost Mn/F dual‐doping Na4Fe3(PO4)2P2O7 cathode can be a competitive candidate material for sodium‐ion batteries.
Porphyrin Helical Nanochannel‐Assembled Polybenzimidazole Membranes Doped with Phosphoric Acid for Fuel Cells Operating in a Temperature Range of 25–200 °C
Authors: Xu Zhipeng , Wang Qiuping , Guo Liang , Li Yeyang , Wang Junyao , Yu Shuaijun , Liao Junbin , Xu Yanqing , Shen Jiangnan 
Published: December 2023

AbstractHigh‐temperature proton‐exchange membrane fuel cells (HT‐PEMFCs) fabricated with phosphoric acid (PA)‐doped polybenzimidazole (PBI) show apparent technical advantages. In practical automotive applications, achieving cold start‐up capability is crucial. In this work, a kind of branched block proton exchange membrane (PEM) based on PBI with a low content of porphyrin ring (<1 mol.%) is reported as a branched monomer. Self‐assembly into high‐density helical nanochannels under the synergistic effect of phase separation and porphyrin π−π stacking, thus the PEM can maintain a high level of PA doping. Specifically, the PA/1.8TCPP‐BrPy‐OPBI membrane shows a proton conductivity of 0.169 and 0.071 S cm−1, as well as an H2‐O2 fuel cell peak power density of 1077 and 357 mW cm−2 at 180 and 80 °C without humidification and backpressure, respectively. The membrane electrode assembly (MEA) can exhibit good fuel cell stability, with a voltage decay rate of only 7.0 µV h−1 at 80 °C. Furthermore, it maintains a peak power density of 93% even after 150 start‐up/shut‐down cycles at 25 °C. This work expands the operating temperature range of conventional PBI membranes between 25 and 200 °C and thus provides a novel strategy for high‐performance PBI‐based HT‐PEMFCs.
High‐Strength, Thin PBO Nanofiber Membrane with Long‐Term Stability for Osmotic Energy Conversion
Authors: Duan Runyu , Zhou Jiale , Zheng Xue , Ma Xiaoyan , Zhai Rui , Hao Junran , Zhou Yahong , Teng Chao , Jiang Lei 
Published: December 2023

AbstractIon‐selective membrane embedded in a reverse electrodialysis system can achieve the conversion of osmotic energy into electricity. However, the ingenious design and development of pure polymer membranes that simultaneously satisfy excellent mechanical strength, long‐term stability, high power density, and increased testing area is a crucial challenge. Here, high‐strength, thin PBO nanofiber membranes (PBONM) with 3D nanofluidic channels and a thickness of 0.81 µm are prepared via a simple vacuum‐assisted filtration technology. The thin PBONM exhibits excellent mechanical properties: stress of 235.8 MPa and modulus of 16.96 GPa, outperforming the state‐of‐the‐art nanofluidic membranes. The obtained PBONM reveals surface‐charge‐governed ion transport behavior and high ion selectivity of 0.88 at a 50‐fold concentration gradient. The PBO membrane‐based generator delivers a power density of 7.7 and 40.2 W m−2 at 50‐fold and 500‐fold concentration gradient. Importantly, this PBONM presents excellent stability in response to different external environments including various saline solutions, pH, and temperature. In addition, the maximum power density of PBONM reaches up to 5.9 W m−2 under an increased testing area of 0.79 mm2, exceeding other membrane‐based generators with comparable testing areas. This work paves the way for constructing high‐strength fiber nanofluidic membranes for highly efficient osmotic energy conversion.
Structural Color Boosted Electrochromic Devices: Strategies and Applications
Authors: Li Lin , Yu Zhumin , Ye Changqing , Song Yanlin 
Published: December 2023

AbstractElectrochromic devices (ECDs) have attracted substantial attention on account of their unique characteristics and prosperous applications. However, their monotonous color modification remains a momentous challenge that significantly restricts their application scope. Integrating structural colors that arise from the interaction between light and periodic micro/nanostructures with electrochromic materials (ECMs) turns out to be an effective approach to enhancing the comprehensive performance of ECDs more than the coloration effectiveness. This review provides an overview on the recent burgeoning development of structural color ECDs regarding strategies and applications. The performance parameters of ECDs and physical principles regarding the generation of structural colors are introduced. Then, strategies that introduce structural colors into ECDs are discussed according to the category of chromogenic micro/nanostructures, namely, gratings, (single‐layer and multilayer) thin films, photonic crystals, plasmonic metasurfaces, and composite structures. The current state‐of‐the‐art research activities of structural color ECDs for display application including segmented and pixelated devices are also presented. Additionally, the future perspective of structural color ECDs with respect of major challenges and potential solutions is proposed.
Selective Shielding of the (002) Plane Enabling Vertically Oriented Zinc Plating for Dendrite‐Free Zinc Anode
Authors: Zhu Qiancheng , Sun Guobing , Qiao Shizhe , Wang Dengke , Cui Ziyang , Zhang Wenming , Liu Jinping 
Published: December 2023

AbstractUncontrolled growth of Zn dendrites hinders the future development of aqueous Zn‐ion batteries. Despite that the (100) plane possesses better zincophilic ability and fast kinetics, dendrites are generally suppressed via (002) plane‐oriented Zn deposition in previous reports; the ordered (100) plane‐dominant Zn deposition, especially under high current density has not yet been realized. Herein, vertically‐oriented Zn plating with preferential growth of (100) plane is reported using disodium lauryl phosphate (DLP) as an electrolyte additive. DLP is preferentially anchored on the Zn (002) crystal plane via the polar phosphate group, then the deposition of Zn atoms on the (002) plane is retarded by the long alkyl chain, finally promoting the preferred growth of the (100) plane. This unique growth pattern results in ultrastable Zn plating/stripping at a super‐high current density of 50 mA cm−2, with a cumulative capacity of 8500 mAh cm−2. The Zn//Zn symmetric cell also cycles steadily for 700 h with a large areal capacity of 10 mAh cm−2 at a current density of 10 mA cm−2. This study provides new insights into the realization of dendrite‐free Zn anodes by crystal plane modulation.
Confinement Engineering of Zinc Single‐Atom Triggered Charge Redistribution on Ruthenium Site for Alkaline Hydrogen Production
Authors: Wan Yinji , Chen Weibin , Wu Shengqiang , Gao Song , Xiong Feng , Guo Wenhan , Feng Long , Cai Kunting , Zheng Lirong , Wang Yonggang , Zhong Ruiqin , Zou Ruqiang 
Published: December 2023

AbstractOptimizing the interaction between metal and support in the supported metal catalysts effectively refines the electronic structure and boosts the catalytic properties of loaded active components. Herein a method is introduced to confine ultrafine ruthenium (Ru) nanoparticles within atomically dispersed Zn‐N4 sites on a N‐doped carbon network (Ru/Zn‐N‐C) through the strong electronic metal–support interaction, achieving superior catalytic activity and stability for alkaline hydrogen evolution. Spectroscopic data and theoretical modeling elucidate that the remarkable catalytic performance of Ru sites stems from their strong electronic coupling with neighboring Zn‐N4 moiety and pyridinic N/pyrrolic N. This interaction induces an electron‐deficient state of Ru, thereby accelerating the dissociation of H2O and lowering the energy barriers for the desorption of OH* and H*. This insight provides a deeper understanding of the catalytic mechanisms at play. Furthermore, alkaline water electrolyzer using this catalyst as cathode delivers a mass activity of 3 A mgcat–1 at 2.0 V, much surpassing Ru‐C. This research opens a novel pathway for the development of advanced materials , tailored for energy storage and conversion applications.
Ultrasensitive NIR‐II Ratiometric Nanothermometers for 3D In Vivo Thermal Imaging
Authors: Li Dan , Jia Mochen , Jia Tao , Chen Guanying 
Published: December 2023

AbstractLuminescent nanothermometry, particularly the one based on ratiometric, has sparked intense research for non‐invasive in vivo or intracellular temperature mapping, empowering their uses as diagnosis tools in biomedicine. However, ratiometric detection still suffers from biased sensing induced by wavelength‐dependent tissue absorption and scattering, low thermal sensitivity (Sr), and lack of imaging depth information. Herein, this work constructs an ultrasensitive NIR‐II ratiometric nanothermometer with self‐calibrating ability for 3D in vivo thermographic imaging, in which temperature‐insensitive lanthanide nanocrystals and strongly temperature‐quenched Ag2S quantum dots are co‐assembled to form a hybrid nanocomposite material. Precise control over the amount ratio between two sub‐materials enables the manipulation of heat‐activated back energy transfer from Ag2S to Yb3+ in lanthanide nanoparticles, thereby rendering Sr up to 7.8% °C−1 at 43.5 °C, and higher than 6.5% °C−1 over the entire physiological temperature range. Moreover, the luminescence intensity ratio between two separated spectral regions within the narrow Yb3+ emission peak is used to determine the depth information of nanothermometers in living mice and correct the effect of tissue depth on 2D thermographic imaging, and therefore allows a proof‐of‐concept demonstration of accurate 3D in vivo thermographic imaging, constituting a solid step toward the development of advanced ratiometric nanothermometry for biological applications.
Designing Carbon‐Based Porous Materials for Carbon Dioxide Capture
Authors: Singh Rasmeet , Wang Lizhuo , Ostrikov Kostya (Ken) , Huang Jun 
Published: December 2023

AbstractRapid industrialization and urban development around the world have significantly increased carbon dioxide emissions, adversely affecting climate and ecosystems. Therefore, carbon capture and storage emerged as a promising route to reduce environmental CO2 concentration. Among various CO2 capture technologies, adsorption through carbon‐based porous materials has attracted particularly strong attention. This is primarily due to their high specific surface area, selective CO2 adsorption, moderate heat of adsorption, tunable morphology, and reduced degradation in moisture. This review critically examines carbon‐based CO2 sorbents derived from diverse sources. The key factors controlling adsorption performance, including the impact of structural and functional properties are discussed. The future research directions in this rapidly emerging field, contributing to the decarbonization of the global economy and society, are highlighted.
Modeling the Transient Behavior of Ionic Diodes with the Nernst–Planck–Poisson Equations
Authors: Tepermeister Max , Silberstein Meredith N. 
Published: December 2023

AbstractIonic circuitry formed from soft charged polymers promises to enable a new kind of analog computing and usher in a new age of human–computer interaction, but devices remain in their infancy. Ionic diodes, created by the interface between two oppositely charged polymers, form one of the most fundamental elements of ionic circuitry. However, it is currently not well understood how the boundary conditions and geometry of a diode influence its transient response and performance. A consistent set of metrics with which to analyze these diodes is first developed, then a continuum model based on the Nernst–Planck–Poisson equations is used to study how device construction and three types of boundary conditions affect performance. This model is solved using the finite volume method and gives insight into transient diode behavior not described by previous analyses. It is demonstrated how different parts of a diode's construction, thickness, and operating voltage act as the limiting factors for different regimes. To conclude, it is demonstrated how blocking electrodes limit both diode lifetime and rectification behavior and how neutral bath boundary conditions play an important role in the performance of some diodes, with recommendations for building higher performance devices in the future.
Uncovering the Hidden World of Aqueous Humor Proteins for Discovery of Biomarkers for Marfan Syndrome
Authors: Shi Yumeng , Chen Jiahui , Cai Lei , Zhang Xueling , Chen Zexu , Yang Jin , Jiang Yongxiang , Lu Yi 
Published: December 2023

AbstractEctopia lentis is a hallmark of Marfan syndrome (MFS), a genetic connective tissue disorder affecting 1/5000 to 1/10 000 individuals worldwide. Early detection in ophthalmology clinics and timely intervention of cardiovascular complications can be lifesaving. In this study, a modified proteomics workflow with liquid chromatography‐tandem mass spectrometry (LC‐MS/MS)‐based data‐independent acquisition (DIA) and field asymmetric ion mobility spectrometry (FAIMS) to profile the proteomes of aqueous humor (AH) and lens tissue from MFS children with ectopia lentis is utilized. Over 2300 and 2938 comparable proteins are identified in AH and the lens capsule, respectively. Functional enrichment analyses uncovered dysregulation of complement and coagulation‐related pathways, collagen binding, and cell adhesion in MFS. Through weighted correlation network analysis (WGCNA) and machine learning, distinct modules associated with clinical traits are constructed and a unique biomarker panel (Q14376, Q99972, P02760, Q07507; gene names: GALE, MYOC, AMBP, DPT) is defined. These biomarkers are further validated using advanced parallel reaction monitoring (PRM) in an independent patient cohort. The results provide novel insights into the proteome characterization of ectopia lentis and offer a promising approach for developing a valuable biomarker panel to aid in the early diagnosis of Marfan syndrome via AH proteome.
Transgenic amyloid precursor protein mouse models of amyloidosis. Incomplete models for Alzheimer's disease but effective predictors of anti‐amyloid therapies
Authors: Morgan David G. , Lamb Bruce T. 
Published: December 2023

AbstractINTRODUCTIONAmyloid precursor protein (APP) transgenic mice are models of Alzheimer's disease (AD) amyloidosis, not all of AD. Diffuse, compacted, and vascular deposits in APP mice mimic those found in AD cases.METHODSMost interventional studies in APP mice start treatment early in the process of amyloid deposition, consistent with a prevention treatment regimen. Most clinical trials treat patients with established amyloid deposits in a therapeutic treatment regimen.RESULTSThe first treatment to reduce amyloid and cognitive impairment in mice was immunotherapy. The APP mouse models not only predicted efficacy, but presaged the vascular leakage called ARIA. The recent immunotherapy clinical trials that removed amyloid and slowed cognitive decline confirms the utility of these early APP models when used in therapeutic designs.DISCUSSIONNew mouse models of AD pathologies will add to the research armamentarium, but the early models have accurately predicted responses to amyloid therapies in humans.
Iridium‐Catalyzed Reductive (3+2) Annulation of Lactams Enabling the Rapid Total Synthesis of (±)‐Eburnamonine
Authors: Sugiyama Yasukazu , Yamada Kento , Kaneko Daiki , Kusagawa Yuya , Okamura Toshitaka , Sato Takaaki 
Published: December 2023

AbstractA reductive (3+2) annulation of lactams through iridium‐catalyzed hydrosilylation and photoredox coupling with α‐bromoacetic acid was developed. The iridium‐catalyzed hydrosilylation of the lactam carbonyl group and subsequent elimination provide a transient cyclic enamine, which undergoes iridium‐catalyzed photoredox coupling with α‐bromoacetic acid in a one‐pot process. The developed conditions show high functional‐group tolerance and provide cyclic N,O‐acetals containing a quaternary carbon center. The resulting N,O‐acetals undergo a variety of acid‐mediated nucleophilic addition reactions via iminium ions to give substituted cyclic amines. The developed sequence including reductive (3+2) annulation and acid‐mediated nucleophilic addition was successfully applied to the four‐step total synthesis of (±)‐eburnamonine.
Maschinelles Lernen zur Vorhersage antibakterieller Aktivität von Ruthenium‐Komplexen**
Authors: Orsi Markus , Shing Loh Boon , Weng Cheng , Ang Wee Han , Frei Angelo 
Published: December 2023

AbstractDie steigende antimikrobielle Resistenz (AMR) und der Mangel an Innovation in der Antibiotikaforschung erfordern neue Ansätze zur Entwicklung von Medikamenten. Metallkomplexe haben sich als vielversprechende antimikrobielle Verbindungen erwiesen. Allerdings ist die Anzahl der untersuchten Verbindungen noch klein, besonders im Vergleich zu den Millionen organischer Moleküle die bereits getestet wurden. In den letzten Jahren hat sich maschinelles Lernen (ML) als wertvolle Ressource für die Entwicklung organischer Moleküle herauskristallisiert, selbst wenn nur wenige Daten vorliegen. Erstmals erweitern wir die Anwendung von ML auf die Entdeckung von metallbasierten antimikrobiellen Verbindungen. Mithilfe von 288 modular synthetisierten Ruthenium‐Aren‐Schiff‐Basen‐Komplexen und deren antibakteriellen Eigenschaften haben wir eine Reihe von ML–Modellen trainiert. Die Modelle zeigen gute Leistungen und werden verwendet, um die Aktivität von 54 neuen Verbindungen vorherzusagen. Diese Verbindungen weisen eine 5.7‐fach höhere Trefferquote (53.7 %) gegen Methicillin‐resistente Staphylococcus aureus (MRSA) im Vergleich zur ursprünglichen Bibliothek (9.4 %) auf. Dadurch zeigen wir, dass ML zu höheren Erfolgsraten bei der Suche nach neuen Metalloantibiotika führen kann. Folglich ebnet diese Arbeit den Weg für fortschrittlichere Anwendungen von ML im Bereich der metallbasierten Wirkstoffentwicklung.