bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of NLRP3 inflammasome activation in patients with chronic obstructive pulmonary disease before and after lung transplantation
Authors: Rumora Lada , Markelić Ivona , Hlapčić Iva , Tomašković Andrea Hulina , Fabijanec Marija , Džubur Feđa , Samaržija Miroslav , Dugac Andrea Vukić 
Published: November 2023

Abstract
The interplay between purinergic receptors as well as pattern recognition receptors like Toll-like receptors (TLRs) and NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) might have a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was to determine and compare the concentrations of the damage-associated molecular patterns (DAMPs) heat shock protein 70 (Hsp70) and adenosine triphosphate (ATP), and gene expression of their respective receptors as well as NLRP3 inflammasome-related molecules in the peripheral blood of patients with end-stage COPD before and one year after lung transplantation (LT). Lung function was assessed by spirometry and diffusion capacity for carbon monoxide (DLCO). Quantitative polymerase chain reaction (qPCR) was applied for detection of TLR2,TLR4, P2X7R, P2Y2R, IL1B, CASP1 and NLRP3 expression. High-sensitivity ELISA kits were used for eHsp70 and IL-1β, and luminescence assay for eATP measurements. Concentrations of eHsp70 and eATP as well as IL-1β were significantly increased in plasma of end-stage COPD patients, and significantly decreased after LT. In addition, TLR4, P2Y2R,IL1B, CASP1 and NLRP3 expression was up-regulated in COPD patients before LT, while it was significantly suppressed after LT. In conclusion, it could be assumed that NLRP3 inflammasome is activated in peripheral blood of end-stage COPD patients, and that eHsp70 and eATP could be responsible for its activation through triggering their receptors. On the other hand, previously enhanced pro-inflammatory reactions seem to be suppressed to the healthy population levels in lung recipients without allograft rejection.
Community overview on the differential prevalence of Hepatitis E in two sub-counties in Kitgum District, Uganda: A qualitative study
Authors: Aloyo Judith , Kiguli Juliet , Orach Christopher Garimoi , Kitara David Lagoro 
Published: November 2023

Abstract

Background: An epidemic of Hepatitis E infection occurred in Kitgum District, Uganda, in 2009. In that epidemic, more than 10,422 people were infected, and over 166 deaths were registered. Kitgum District Health Management Information Systems (HMIS) showed that Hepatitis E cases continued to occur in Mucwini more than in the Kitgum Matidi sub-county despite instituting similar epidemic control measures in the two communities. The tenacity of the virus in the Mucwini sub-county had remained unclear.
This study aimed at assessing communities’ views and perspectives on the differential prevalence of Hepatitis E in the two sub-counties of Kitgum Matidi and Mucwini in Northern Uganda.
Methods: A cross-sectional study using qualitative methods was conducted. Four Focus Group discussions and six key informant interviews were conducted with the village health teams, local council chairpersons, health workers, and community members. These participants were chosen purposively because of their expertise and experience in community health services. Face-to-face interview guides were administered to obtain detailed information on factors associated with the differential occurrence of Hepatitis E in the two sub-counties. This study was approved by a local IRB and the Uganda National Council of Science and Technology (UNCS&T).
Results: The most substantial findings from this study were the differences in prevention and control practices in the two communities. Residents of Mucwini were less compliant with infection, prevention, and control guidelines, and disagreements between local councilors and village health teams in Mucwini over allowances led to poor implementation and non-adherence to guidelines on community control of Hepatitis E.
Conclusion: A differentially higher prevalence of Hepatitis E in Mucwini than in the Kitgum Matidi sub-county resulted from poor personal and community hygiene and non-adherence to behavior change communication among residents of Mucwini than their counterparts in Kitgum Matidi. The authors recommend a more proactive approach to managing an epidemic by securing the willingness of the affected community to adopt appropriate infection prevention and control guidelines. In addition, disagreements among stakeholders should be resolved quickly so that all community members adhere to control measures.
Workplace Support for Physicians during the COVID-19 Pandemic: Did it affect burnout?
Authors: Melnikow Joy , Xing Guibo , Miller Marykate , Loureiro Sabrina , Whitney Robin , Kravitz Richard L. 
Published: November 2023

Abstract

Background: A concern before 2020, physician burnout worsened during the COVID-19 pandemic. Little empirical data are available on pandemic workplace support interventions or their influence on burnout. We surveyed a national sample of frontline physicians on burnout and workplace support during the pandemic.Methods: We surveyed a stratified random sample of 12833 US physicians most likely to care for adult COVID-19 patients from the comprehensive AMA Physician Professional Data ™ file. The sample included 6722 primary care physicians (3331 family physicians, 3391 internists), 880 hospitalists, 1783 critical care physicians (894 critical care physicians, 889 pulmonary intensivists), 2548 emergency medicine physicians, and 900 infectious disease physicians. The emailed survey elicited physicians’ perceptions of organizational interventions to provide workplace support and/or to address burnout. Burnout was assessed with the Professional Fulfillment Index Burnout Composite scale (PFI-BC). Proportional specialty representation and response bias were addressed by survey weighting. Logistic regression assessed the association of physician characteristics and workplace interventions with burnout.Results: After weighting, respondents were representative of the total sample. Overall physician burnout was 45.4%, significantly higher than in our previous surveys. Open-ended responses mentioned that staffing shortages (physician, nursing, and other staff) combined with the increased volume, complexity, and acuity of patients during the pandemic increased job demands. The most frequent workplace support interventions were direct pandemic control measures (increased access to personal protective equipment, 70.0%); improved telehealth functionality (43.4%); and individual resiliency tools (yoga, meditation, 30.7%). Respondents placed highest priority on workplace interventions to increase financial support and increase nursing and clinician staffing. Factors significantly associated with lower odds of burnout were practicing critical care (compared with emergency medicine) OR 0.33 (95% CI 0.12–0.93), improved telehealth functionality OR 0.47 (95% CI 0.23–0.97) and being in practice for 11 years or longer OR 0.44 (95% CI 0.19–0.99).Conclusions: Burnout across frontline specialties increased during the pandemic. Physician respondents focused on inadequate staffing in the context of caring for more and sicker patients, combined with the lack of administrative efforts to mitigate problems. Burnout mitigation requires system-level interventions beyond individual-focused stress reduction programs to improve staffing, increase compensation, and build effective teams.
PENGARUH DAYA TARIK DAN HASIL REVIEW MELALUI MEDIA SOSIAL TERHADAP KEPUTUSAN MASYARAKAT BERKUNJUNG KE MASJID RAYA SYEIKH ZAYED SURAKARTA
Authors: Nafii'ah Dzul Fahma , Grahesti Angrahita , Putri Adevia Ristina 
Published: November 2023

Abstrak: Perkembangan tren pariwisata halal dari tahun ke tahun menjadikan daya tarik tersendiri bagi umat muslim. Indonesia dengan peringkat ke-1 pada tahun 2023 dalam pariwisata halal semakin dapat melebarkan sayapnya untuk meningkatkan potensi dari pariwisata halal yang salah satunya ialah masjid. Tujuan penelitian ini guna mengetahui adakah pengaruh daya tarik dan hasil review melalui media sosial terhadap keputusan masyarakat untuk berkunjung di Masjid Raya Syeikh Zayed Banjarsari Surakarta. Metode yang digunakan oleh penulis yaitu kuantitatif dengan analisis regresi linear berganda berupa alat SPSS versi 25 dan teknik sampling berupa purposive sampling. Penelitian ini menggunakan data primer yang diperoleh dari hasil penyebaran kuesioner dan sekunder yang merujuk pada literatur-literatur yang relevan. Hasil dari penelitian menunjukkan bahwa secara simultan daya tarik dan hasil review berpengaruh secara signifikan terhadap keputusan masyarakat berkunjung ke Masjid Raya Syeikh Zayed. Sedangkan secara parsial, variabel daya tarik memiliki pengaruh yang signifikan terhadap keputusan masyarakat untuk berkunjung ke Masjid Raya Syeikh Zayed. Berbeda dengan hasil review tidak berpengaruh secara signifikan terhadap keputusan masyarakat berkunjung ke Masjid Raya Syeikh Zayed.
Kata kunci: Review Melalui Social Media; Daya Tarik; Hasil Review; Keputusan Berkunjung; Pariwisata Halal

Abstract: The development of halal tourism trends from year to year makes it a special attraction for Muslims. Indonesia, which ranks 1st in 2023 in halal tourism, can increasingly spread its wings to increase the potential for halal tourism, one of which is mosques. The aim of this research is to find out whether there is an influence of attractiveness and the results of reviews via social media on people's decisions to visit the Grand Mosque of Sheikh Zayed Banjarsari Surakarta. The method used by the author is quantitative with multiple linear regression analysis in the form of SPSS version 25 tools and a sampling technique in the form of purposive sampling. This research uses primary data obtained from the results of distributing questionnaires and secondary data which refers to relevant literature. The results of the research show that simultaneously the attraction and the results of the review have a significant influence on people's decisions to visit the Sheikh Zayed Grand Mosque. Meanwhile, partially the attractiveness variable has a significant influence on people's decisions to visit the Sheikh Zayed Grand Mosque. In contrast to the results of the review, it does not significantly influence people's decisions to visit the Sheikh Zayed Grand Mosque.
Keywords: Review Via Social Media; Attractiveness; Review Results; Decision to Visit; Halal Tourism
MEMBANGUN RETENSI WISATAWAN MELALUI ATRIBUT RAMAH HALAL DI DESTINASI WISATA RELIGI DEMAK KOTA WALI
Authors: Saifudin Saifudin , Khusna Atiatul , Rusdian Azi , Sanjaya Intan Winda Widya 
Published: November 2023

Abstrak: Peneliti terdahulu telah banyak yang melakukan penelitian di sektor industri pariwisata dengan memperhatikan fenomena di sektor wisata religi, namun kajian mendalam tentang aspek wisata ramah-halal masih kurang. Tulisan ini bertujuan untuk mengetahui pengaruh dari ramah-halal terhadap retensi wisatawan pada wisata religi di Kabupaten Demak. Ramah-halal pada penelitian ini terbatas pada variable-variabel seperti akomodasi ramah-halal, makanan halal, fasilitas ramah-halal, pelayanan ramah-halal serta lokal ramah-halal dan wisata lainnya (sosial-budaya penduduk setempat). Populasi dalam penelitian ini adalah jumlah pengunjung wisata religi di Demak. Sampel sebanyak 534 responden yangdiambil dengan cara incidental sampling. Alat bantu analisis yang digunakan adalah SmartPLS 3.2.9. Hasil penelitian menjelaskan bahwa akomodasi ramah-halal, fasilitas ramah-halal, penduduk lokal ramah-halal dan wisata lainnya (sosial-budaya penduduk setempat) berpengaruh terhadap retensi wisatawan. Sedangkan, makanan halal dan pelayanan ramah-halal tidak berpengaruh terhadap retensi wisatawan.
Kata Kunci: Ramah-Halal; Retensi Wisatawan; Akomodasi; Makanan; Fasilitas; Pelayanan; Lokal

Abstract: Many previous researchers have conducted research in the tourism industry sector by paying attention to phenomena in the religious tourism sector, but in-depth studies on aspects of halal-friendly tourism are still lacking. This study aims to determine the effect of halal-friendly on tourist retention in religious tourism in Demak Regency. Halal-friendly in this study is limited to variables, such as halal-friendly accommodation, halal food, halal-friendly facilities, halal-friendly services and halal-friendly locales and other tours (socio-cultural of the local population). The population in this study is the number of religious tourism visitors in Demak. A sample of 534 respondents was taken by incidental sampling.The analytical tool used is SmartPLS 3.2.9. The results of the study explain that halal-friendly accommodation, halal-friendly facilities, halal-friendly locales and other tours (socio-cultural of the local population) have an effect on tourist retention. Meanwhile, halal food and halal friendly services have no effect on tourist retention.
Keywords: Halal-Friendly; Tourist Retention; Accommodation; Food; Facility; Service; Local
A Framework for Teaching Music Online. By Carol Johnson. Bloomsbury Academic.
Authors: Duggleby Sandra 
Published: November 2023

In A Framework for Teaching Music Online, Carol Johnson formulates a clear and precise framework for teaching music online that is supported by 17 peer-reviewed articles she has authored on this topic. Well-known for her scholarship, Johnson’s framework is designed to guide online teachers of music through a well-reasoned and logical step-by-step process using clear communication, authentic design, and quality assessment. The three-part process explores her framework starting with design and assessment of case studies. She then focuses on practical application of designing an online teaching space using technology tools and approaches as supporting learning mechanisms. In the final section of the framework, Johnson capitalizes on future innovations that delve into sharing knowledge and creating professional learning networks. The framework masterfully allows for discipline specificity in an arts-based discipline with niche areas such as music performance, theory, history, and composition. Johnson ensures that authentic supports are in place for all.
Prevalencia de ansiedad matemática en universitarios
Authors: Zamora-Lugo Samuel , Cadena-Barajas Martín , Franci Alessio , Cibrián-Llanderal Tamara 
Published: November 2023

Los datos presentados a continuación son el resultado de una investigación orientada a describir y comparar el índice de ansiedad matemática en estudiantes universitarios de diferentes áreas de conocimiento, así como su comorbilidad con los rasgos de ansiedad en general. Se aplicó un cuestionario con datos sociodemográficos y con el Índice de Ansiedad Matemática y el Inventario de Ansiedad de Beck a 526 estudiantes con edad promedio de 21.7 años, de las siguientes áreas académicas: Ciencias Fisicomatemáticas e Ingenierías, Ciencias Biológicos Agropecuarias, Ciencias de la Salud, Económico-Administrativo, Humanidades y Técnica. De manera muy concreta se observó que los estudiantes pertenecientes a las áreas de Humanidades y Ciencias Biológicas-Agropecuarias presentaron mayores puntajes en el índice de Ansiedad Matemática, mientras que los alumnos del área Económico-Administrativa y Ciencias Físico Matemáticas e Ingeniería obtuvieron los menores puntajes lo que significan que presentan menores rasgos de ansiedad matemática.0020La interpretación de los datos fue lo que se esperaba, a pesar de que los alumnos de Humanidades y Ciencias Biológicas-Agropecuarias no cursan experiencias educativas que involucren el manejo de cuestiones matemáticas, sigue habiendo una respuesta negativa latente hacia la disciplina predominando la variable actitud hacia las matemáticas.
NOTAS SOBRE A FUNÇÃO PRAGMÁTICA DA AMIZADE NO PROCESSO EDUCATIVO KANTIANO
Authors: Da Silva Filho Tomaz Martins 
Published: November 2023

RESUMO

O texto trata sobre o conceito de amizade em Kant, a partir da obra Sobre a Pedagogia. Kant, nesse escrito, afirma que a criança deve manter relações de amizade com os outros e não viver sempre isoladamente. Sabe-se que a amizade não é um tema central da filosofia crítica, entretanto, o filósofo dedica diversos parágrafos ao tema nas Lições de Ética, na Metafísica dos Costumes, na Antropologia de um ponto de vista pragmático e na obra Sobre a Pedagogia. Assim, podemos nos questionar: no contexto geral da antropologia kantiana, que papel desempenha a amizade (Freundschat) para que o filósofo dedique-lhe seguidos parágrafos? Talvez, a resposta a esse questionamento não esteja propriamente na Antropologia de um ponto de vista Pragmático, mas na obra Sobre a Pedagogia. Observar a amizade a partir da Pedagogia é perceber que não estamos diante de um mero sentimento, porém, de uma habilidade inerente à vida em sociedade. Tal habilidade deve ser cultivada como um traço do caráter da criança, visando ao desenvolvimento da sociabilidade e, portanto, evitar o isolamento. Com isso, previne-se também os vícios da misantropia e da ferocidade, típicos da indisciplina selvagem.
Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic
Pathway-linked Anti-depressive-like Effects in Mice
Authors: de Siqueira Patriota Leydianne Leite , de Lima Barbara Raíssa Ferreira , de Oliveira Marinho Amanda , da Costa Jainaldo Alves , Barroso Coelho Luana Cassandra Breitenbach , de Melo Rêgo Moacyr Jesus Barreto , da Rocha Pitta Maira Galdino , Paiva Patrícia Maria Guedes , Pereira Michelly Cristiny , Napoleão Thiago Henrique , da Rosa Michelle Melgarejo 
Published: November 2023

Objectives:
The present study investigated the anti-depressive-like (anti-immobility) effect
of a lectin from Moringa oleifera seeds (WSMoL) in mice.

Methods:
To evaluate an acute effect, the animals were treated with WSMoL (1, 2, and 4 mg/kg,
i.p.) 30 min before the tail suspension test (TST). To investigate the involvement of monoaminergic
and nitrergic signaling, the mice were pre-treated with selective antagonists. The role of the WSMoL
carbohydrate-recognizing domain (CRD) was verified using previous blockage with casein
(0.5 mg/mL). The subacute anti-immobility effect was also evaluated by administering WSMoL
(1, 2, and 4 mg/kg, i.p.) once a day for 7 d. Finally, an open field test (OFT) was performed to
identify possible interferences of WSMoL on animal locomotory behavior.

Results:
WSMoL reduced the immobility time of mice in the TST at all doses, and combined treatment
with fluoxetine (5 mg/kg, i.p.) and WSMoL (1 mg/kg) was also effective. The CRD appeared
to be involved in the anti-immobility effect since the solution of WSMoL (4 mg/kg) pre-incubated
with casein showed no activity. The lectin effect was prevented by the pre-treatment of
mice with ketanserin, yohimbine, and SCH 23390, thereby demonstrating the involvement of
monoaminergic pathways. In contrast, pre-treatment with L-NAME, aminoguanidine, and L-arginine
did not interfere with lectin action. WSMoL exhibited a subacute effect in the TST, thereby
reducing immobility time and increasing agitation time even on the seventh day. OFT data revealed
that the anti-immobility effect was not caused by interference with locomotor behavior.

Conclusion:
WSMoL elicits an anti-depressant-like effect that is dependent on monoaminergic
signaling.
Non-synonymous Single Nucleotide Polymorphisms in Human ACE2 Gene May
Affect the Infectivity of SARS-CoV-2 Omicron Subvariants
Authors: Samanta Arijit , Ahamed Ashif , Alam Syed Sahajada Mahafujul , Ali Safdar , Shahnawaz Khan Mohd. , Al-Amri Abdulaziz M. , Tabrez Shams , Hoque Mehboob 
Published: November 2023

Background:
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus
disease 2019 (COVID-19), which first appeared in December 2019. Angiotensin I converting enzyme
2 (ACE2) receptor, present on the host cells, interacts with the receptor binding domain (RBD) of spike (S)
protein of SARS-CoV-2 and facilitates the viral entry into host cells.

Methods:
Non-synonymous single nucleotide polymorphisms (nsSNPs) in the ACE2 gene may have an impact
on the protein's stability and its function. The deleterious or harmful nsSNPs of the ACE2 gene that can
change the strength as well as the pattern of interaction with the RBD of S protein were selected for this study

Results:
The ACE2:RBD interactions were analyzed by protein-protein docking study. The missense mutations
A242V, R708W, G405E, D292N, Y633C, F308L, and G405E in ACE2 receptor were found to interact
with RBD of Omicron subvariants with stronger binding affinity. Among the other selected nsSNPs of human
ACE2 (hACE2), R768W, Y654S, F588S, R710C, R710C, A191P, and R710C were found to have lower binding
affinity for RBD of Omicron subvariants.

Conclusion:
The findings of this study suggest that the nsSNPs present in the human ACE2 gene alter the
structure and function of the protein and, consequently, the susceptibility to Omicron subvariants.
Comprehensive Analyses and Experiments Confirmed IGFBP5 as a
Prognostic Predictor Based on an Aging-genomic Landscape Analysis of
Ovarian Cancer
Authors: Fan Ting-Yu , Xu Li-li , Zhang Hong-Feng , Peng Juan , Liu Dan , Zou Wen-Da , Feng Wen-Jie , Qin Mei , Zhang Juan , Li Hui , Li Yu-Kun 
Published: November 2023

Background::
Ovarian cancer (OC) is one of the malignant diseases of the reproductive
system in elderly women. Aging-related genes (ARGs) were involved in tumor malignancy and
cellular senescence, but the specifics of these mechanisms in OC remain unknown.

Methods::
ARGs expression and survival data of OC patients were collected from TCGA and CPTAC
databases. Subtype classification was used to identify the roles of hub ARGs in OC progression,
including function enrichment, immune infiltration, and drug sensitivity. LASSO regression
was utilized to confirm the prognosis significance for these hub ARGs. MTT, EdU, Transwell,
and wounding healing analysis confirmed the effect of IGFBP5 on the proliferation and migration
ability of OC cells.

Results::
ARGs were ectopically expressed in OC tissues compared to normal ovary tissues. Three
molecular subtypes were divided by ARGs for OC patients. There were significant differences in
ferroptosis, m6A methylation, prognosis, immune infiltration, angiogenesis, differentiation level,
and drug sensitivity among the three groups. LASSO regression indicated that 4 signatures, FOXO4,
IGFBP5, OGG1 and TYMS, had important prognosis significance. Moreover, IGFBP5 was
significantly correlated with immune infiltration. The hub ARG, IGFBP5, expression was significantly
decreased in OC patients compared to normal women. IGFBP5 could also reduce the migration
and proliferation ability of OC cells compared to vector and NC groups.

Conclusion::
IGFBP5 was correlated with OC prognosis and associated with OC migration and
proliferation. This gene may serve as potential prognostic biomarkers and therapeutic targets for
OC patients.