bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of COVID-19 outcome in type 2 diabetes mellitus: a hospital-based study
Authors: Elsayed Amira M. , Elsayed Mohamad S. , Mansour Ahmed E. , Mahedy Ahmed W. , Araby Eman M. , Morsy Maha H. , Abd Elmoniem Rasha O. 
Published: January 2024

Abstract
Background
Diabetes has become a significant risk factor for COVID-19-related severe illness and death.

Methods
This was a retrospective cohort study of 104 patients, with or without type 2 (diabetes mellitus) DM, diagnosed with COVID-19 between June and September 2021 in Benha University Hospital, Egypt. Outcome measures including discharge after recovery, transfer to ICU and intubation, or death were recorded. Univariate and multivariate logistic regression analysis was done for the prediction of death in diabetic patients.

Results
Length of hospital stay was significantly higher in diabetic (median 15 days) compared to non-diabetic patients (median 10 days). ICU admission and intubation among diabetic patients were substantially higher than non-diabetics. Univariate regression analysis established that old age (p = 0.02: OR = 1.03: CI 1.00–1.07), multiple comorbidities (p = 0.005: OR = 8.66: CI 1.9–38.5), diabetic complications (p = 0.000: OR = 6.401:CI 2.5–16.3), HbA1c (p = 0.01: OR = 1.22: CI 1.04–1.43), length of hospital stay (p = 0.005: OR = 1.07: CI 1.02–1.12), and ICU admission (p = 0.00: OR = 44.1: CI 9.4–205.3) were predictors of death for diabetic patients as well as neutrophilic count, D-dimer, and CRP levels. Multivariate regression analysis concluded that ICU admission was the most significant predictor of death in diabetic patients.

Conclusion
Type 2 DM patients, infected with the COVID-19 virus exhibited more admission to ICU and intubation with longer hospital stays compared to those without diabetes with a similar death rate. Old age, HbA1C, comorbidities, diabetic complications, length of hospital stay and ICU admission, and inflammatory parameters were significant predictors of death in diabetic patients.
A meta-analysis of randomized clinical trials on the effect of metformin vs. pioglitazone monotherapy on plasma adiponectin levels among patients with diabetes mellitus
Authors: Arbas Roselle , Dayrit Sofia Alexis , Dimalanta Arah , Flores John Ashley , Mañalac Arch Raphael , Soriano Dinah Rose , Vallo Johana , Tiongco Raphael Enrique , Pineda-Cortel Maria Ruth 
Published: January 2024

Abstract
Background
Limited and contradicting findings were observed on the effects of both metformin (MET) and pioglitazone (PIO) on adiponectin (ADP) levels. Hence, we performed a meta-analysis of randomized control trials to obtain more precise estimates. Studies were searched, screened, and identified through different database sites. Data from included studies were extracted, pooled, and analyzed. Mean and standardized mean differences were computed with their corresponding confidence intervals.

Results
Overall, five studies were included in the meta-analysis. Pooled outcomes suggest that patients with diabetes receiving PIO treatment have significantly increased ADP levels. On the other hand, no significant differences were observed for those treated with MET. Other diabetes-related parameters were tested, comparing the effect of MET vs. PIO treatment, and yielded significant results for HOMA-IR and BMI.

Conclusion
Our study suggests that PIO significantly affects ADP levels compared to MET among patients with diabetes mellitus. However, further studies are needed to verify these claims.
Sinus arrest associated with diabetic ketoacidosis regressing to sinus rhythm after compensation of diabetic process: a case report and review of literature
Authors: Bouchaala Abderrahmane , Nguadi Jaouad , Mouine Najat , Bouzelmat Hicham , Benyass Aatif 
Published: January 2024

Abstract
Background
Diabetic ketoacidosis (DKA) is a serious, life-threatening condition known for its profound hydro electrolytic disturbances and multiple complications, including cerebral edema and circulatory collapse. While this complication is traditionally associated with patients suffering from type 1 diabetes, numerous studies have documented its non-negligible incidence in type 2 diabetics. However, conductive disorders that manifest during its course, such as sinus arrest, are poorly reported and can be life-threatening on their own when not promptly recognized and treated. The primary objective of this report is to increase awareness regarding the uncommon conduction complications associated with diabetic ketoacidosis, even in the absence of overt hyperkalemia, and to underscore the critical significance of early diagnosis and prompt intervention in managing these complications.

Case presentation
We present the case of a middle-aged man with past history of type 2 diabetes whose symptoms included asthenia and consciousness disorder concomitant with ketoacidosis decompensation. Electrocardiogram (ECG) revealed the presence of sinus arrest with ventricular escaping rhythm. Rapid management of the diabetic decompensation led to spontaneous restoration of normal sinus rhythm, thus obviating the necessity for permanent pacing in the patient.

Conclusions
Atypical complications arising during ketoacidosis decompensation, including conditions like sinus arrest, are frequently overlooked and tend to carry a guarded prognosis. Proper recognition and prompt treatment are imperative to achieve the optimal clinical outcome.
Accurate compressive strength prediction using machine learning algorithms and optimization techniques
Authors: Lan Wenbin 
Published: January 2024

AbstractNumerous components' complex interrelationships and interconnectedness present a formidable obstacle in developing mix designs for high-performance concrete (HPC) formulation. The effectiveness of machine learning (ML) algorithms in resolving this paradox has been illustrated. However, they are classified as opaque black-box models due to the lack of a discernible correlation between blend ratios and compressive durability. The present study proposes a semi-empirical methodology that integrates various techniques, including non-dimensionalization and optimization, to overcome this constraint. The methodology exhibits a noteworthy level of accuracy when forecasting compressive strength (CS) across a spectrum of divergent datasets, thus evincing its extensive and all-encompassing efficacy. Moreover, the precise relationship that semi-empirical equations convey is of great significance to practitioners and researchers in this field, especially with respect to their predictive abilities. The determination of CS in concrete is a critical facet of the design of HPC. An exhaustive comprehension of the intricate interplay between manifold factors is requisite to attain an ideal blend proportion. The study’s findings indicate that$$RF$$RFcan accurately predict$$CS$$CS. Moreover, the combination of optimization algorithms significantly enhances the model’s effectiveness. Among the three Optimization Algorithms under consideration, the COA optimizer has exhibited superior performance in augmenting the accuracy and precision of the RF prediction model for CS. As a result, RFCO obtained the more suitable value ofR2and RMSE obtained 0.998 and 0.88, alternatively.
Insufficient Bone Mineralization to Sustain Mechanical Load of Weight in Obese Boys: A Cross-Sectional Study
Authors: Emeriau Fabienne , Amsellem-Jager Jessica , Bouhours-Nouet Natacha , Donzeau Aurelie , Rouleau Stephanie , Rerat Solène , Labarre Emmanuelle , Levaillant Lucie , Coutant Régis 
Published: January 2024

Abstract

Context
The increase in bone mineral content (BMC) and density (BMD) measured by dual-energy x-ray absorptiometry (DXA) in obese children may not sustain the mechanical load associated with weight, and the factors influencing bone mineralization are not well known.

Objective
We described bone mineralization in boys with overweight/obesity and leanness in relation to body composition.

Methods
Cross-sectional study in the Pediatric Endocrinology Unit of Angers University Hospital with 249 overweight/obese boys aged 8-18 who underwent DXA and insulin, testosterone, and IGF-1 measurements. Bone mineralization was compared with data from 301 lean boys of similar age and height from NHANES 2011-2015, using the same DXA model. Path analyses were performed to evaluate factors associated with total body less head (TBLH) BMC.

Results
The mean age- and height-adjusted difference in TBLH BMC between obese and lean boys was 241 ± 20 g/cm2. Each 1 kg/m2 increase in BMI was associated with +39 ± 6 g of TBLH BMC in lean subjects vs + 25 ± 3 g in obese subjects (P &lt; .05). Each 1 kg/m2 increase in lean BMI (LBMI) was associated with +78 ± 5 g of TBLH BMC in lean and obese boys, and each 1 kg/m2 increase in fat mass index (FMI) was associated with a decrease of 9 ± 3 g of TBLH BMC. The TBLH BMC was directly positively influenced by LBMI and indirectly and positively influenced by IGF-1, testosterone, and insulin (mediated through height and LBMI). FMI indirectly influenced TBLH BMC, both positively through LBMI and negatively through its negative impact on IGF-1 and testosterone.

Conclusion
The increase in bone mineralization in obese children does not adapt to the increase in body mass.
Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines
Authors: Fitz Victoria , Graca Sandro , Mahalingaiah Shruthi , Liu Jing , Lai Lily , Butt Ali , Armour Mike , Rao Vibhuti , Naidoo Dhevaksha , Maunder Alison , Yang Guoyan , Vaddiparthi Vaishnavi , Witchel Selma F , Pena Alexia , Spritzer Poli Mara , Li Rong , Tay Chau , Mousa Aya , Teede Helena , Ee Carolyn 
Published: January 2024

Abstract

Context
Insulin resistance is common in women with polycystic ovary syndrome (PCOS). Inositol may have insulin sensitizing effects; however, its efficacy in the management of PCOS remains indeterminate.

Objective
To inform the 2023 international evidence-based guidelines in PCOS, this systematic review and meta-analysis evaluated the efficacy of inositol, alone or in combination with other therapies, in the management of PCOS.

Data Sources
Medline, PsycInfo, EMBASE, All EBM, and CINAHL from inception until August 2022.

Study Selection
Thirty trials (n = 2230; 1093 intervention, 1137 control), with 19 pooled in meta-analyses were included.

Data Extraction
Data were extracted for hormonal, metabolic, lipids, psychological, anthropometric, reproductive outcomes, and adverse effects by 1 reviewer, independently verified by a second.

Data Synthesis
Thirteen comparisons were assessed, with 3 in meta-analyses. Evidence suggests benefits for myo-inositol or D-chiro-inositol (DCI) for some metabolic measures and potential benefits from DCI for ovulation, but inositol may have no effect on other outcomes. Metformin may improve waist-hip ratio and hirsutism compared to inositol, but there is likely no difference for reproductive outcomes, and the evidence is very uncertain for body mass indexI. Myo-inositol likely causes fewer gastrointestinal adverse events compared with metformin; however, these are typically mild and self-limited.

Conclusion
The evidence supporting the use of inositol in the management of PCOS is limited and inconclusive. Clinicians and their patients should consider the uncertainty of the evidence together with individual values and preferences when engaging in shared decision-making regarding the use of inositol for PCOS.
Accidental Cushing Syndrome
Authors: Kousoula Konstantina , Ragnarsson Oskar , Trimpou Penelope 
Published: January 2024

Abstract
We present a patient with Cushing syndrome secondary to accidental intake of corticosteroid tablets—a 66-year-old woman with a history of well-controlled hypertension, who over the course of a few weeks developed full-blown Cushing syndrome with uncontrolled blood pressure, typical central fat accumulation, and easy bruising. The clinical features further worsened upon increase of the dosage of her antihypertensive medication because of rising blood pressure. Biochemical analyses showed low cortisol and ACTH concentrations. Inspection of the patient's medications revealed that she had accidentally been taking corticosteroids tablets, prescribed for her husband, instead of antihypertensives, ie, dexamethasone 4 mg and then 8 mg, instead of candesartan at the same dose.
This case highlights the necessity of a thorough review of the medications taken by patients suspected to have exogenous Cushing syndrome, including inspection of the original packaging, and not just relying on information from the patient and electronic health records. This case also highlights the need of special labeling on the packaging for the easy identification of corticosteroid-containing medications given their widespread availability.
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila
Authors: Kosakamoto Hina , Miura Masayuki , Obata Fumiaki 
Published: January 2024

ABSTRACT
The insect epidermis forms the exoskeleton and determines the body size of an organism. How the epidermis acts as a metabolic regulator to adapt to changes in dietary protein availability remains elusive. Here, we show that the Drosophila epidermis regulates tyrosine (Tyr) catabolism in response to dietary protein levels, thereby promoting metabolic homeostasis. The gene expression profile of the Drosophila larval body wall reveals that enzymes involved in the Tyr degradation pathway, including 4-hydroxyphenylpyruvate dioxygenase (Hpd), are upregulated by increased protein intake. Hpd is specifically expressed in the epidermis and is dynamically regulated by the internal Tyr levels. Whereas basal Hpd expression is maintained by insulin/IGF-1 signalling, Hpd induction on high-protein diet requires activation of the AMP-activated protein kinase (AMPK)–forkhead box O subfamily (FoxO) axis. Impairment of the FoxO-mediated Hpd induction in the epidermis leads to aberrant increases in internal Tyr and its metabolites, disrupting larval development on high-protein diets. Taken together, our findings uncover a crucial role of the epidermis as a metabolic regulator in coping with an unfavourable dietary environment.
Αντιλήψεις και εμπειρίες γυναικών Σχολικών Κοινωνικών Λειτουργών για τη χρήση του Κινηματογράφου ως εργαλείου παρέμβασης στην εκπαίδευση
Authors: Νικολαΐδου Σοφία 
Published: January 2024

Το άρθρο αυτό στηρίζεται σε έρευνα, η οποία εξετάζει τις αντιλήψεις και τις εμπειρίες των σχολικών κοινωνικών λειτουργών σχετικά με τη χρήση του κινηματογράφου ως εργαλείο παρέμβασης σχολικής κοινωνικής εργασίας, με σκοπό την ανάδειξη των ωφελημάτων και των δυσκολιών που ενέχει η χρήση του. Για τη μέθοδο συλλογής και ανάλυσης της παρούσας έρευνας επιλέχθηκε η ποιοτική μεθοδολογία, όπου η συλλογή των δεδομένων έγινε μέσα από δώδεκα ημι- δομημένες συνεντεύξεις σε γυναίκες κοινωνικούς λειτουργούς, με εμπειρία σε ελληνικά δημόσια σχολεία από δέκα μήνες έως εφτά έτη. Οι συνεντεύξεις διεξήχθησαν διαδικτυακά και σε διάστημα δύο μηνών μεταξύ Νοέμβριου-Δεκεμβρίου 2021. Η ανάλυση των δεδομένων έγινε μέσω θεματικής ανάλυσης, όπου αναδείχθηκαν οφέλη τόσο για τους συμμετέχοντες της παρέμβασης όσο και για τους ίδιους τους σχολικούς κοινωνικούς λειτουργούς. Με τους πρώτους, αναδείχθηκε κυρίως η έκφραση των συναισθημάτων, η καλλιέργεια ενσυναίσθησης και κοινωνικών δεξιοτήτων, η θετική αλλαγή στάσεων, καθώς και η ενίσχυση ψυχικής ανθεκτικότητας. Έπειτα, οι σχολικοί κοινωνικοί λειτουργοί συνέβαλαν ώστε να αναδειχθεί σημαντικότατα η διευκόλυνση εκτίμησης, εξατομίκευσης και αξιολόγησης περιπτώσεων, επαγγελματικής εξέλιξης κ.α. Από την ανάλυση, προέκυψαν και οι δυσκολίες, όπως, ο ελάχιστος διαθέσιμος χρόνος για την παρέμβαση σε σχέση με τον χρόνο που απαιτείται για τη χρήση ταινιών ή βίντεο, η έλλειψη πόρων και υποστήριξης από το εκπαιδευτικό πλαίσιο, οι δυσκολίες εφαρμογής της παρέμβασης κ.α. Επιπλέον, προέκυψε πως ο κινηματογράφος ως εργαλείο παρέμβασης μπορεί να χρησιμοποιηθεί σε ομαδικές, ατομικές και κάτω από συγκεκριμένες θεματολογικές παρεμβάσεις, έχοντας υπόψιν στα σημεία που χρήζουν προσοχής κατά τη χρήση του. Τέλος, μέσα από τα ευρήματα της παρούσας έρευνας, αναδείχθηκε ο κινηματογράφος ως μία ιδιαίτερα χρήσιμη προσθήκη στις παρεμβάσεις της σχολικής κοινωνικής εργασίας.
The Sacraments at the Service of Communion in Unity with the Eucharist
Authors: Kwiatkowski Dariusz 
Published: January 2024

Sakramenty w służbie komunii w jedności z Eucharystią
Artykuł ukazuje jedność teologiczną i celebracyjną Eucharystii z sakramentami w służbie Komunii, czyli z sakramentem święceń i sakramentem małżeństwa. Sprawowanie tych sakramentów w jednej celebracji liturgicznej wynika nie tyle z przepisów rubrycystycznych ale z ich ontologicznej jedności. Jest to bardzo czytelne w przypadku sakramentu święceń, gdyż został on ustanowiony wspólnie z Eucharystią. Źródłem łaczącym oba sakramenty jest Jezus Chrystus – Najwyższy Kapłan i jednocześnie Ofiara złożona przez Niego na krzyżu. Nie może być Eucharystii bez kapłaństwa i kapłaństwa bez Eucharystii. Sakrament małżeństwa będący znakiem Nowego Przymierza również prowadzi do Eucharystii, która to przymierze celebruje i uobecnia w sakramentalnych znakach. Miłość Chrystusa uobecniająca się w Eucharystii, umacnia i uświęca miłość nowożeńców, wyznawaną w sakramencie małżeństwa. Oznacza to, że nigdy nie powinno się traktować mszy świętej jako specjalnego dodatku do celebracji sakramentu małżeństwa. Komunia eucharystyczna bowiem tworzy i buduje komunię małżeńską.
Successful management of severe hypoglycemia induced by total parenteral nutrition in patients with hepatocellular injury: Three cases reports
Authors: Fang Ling-Zhi , Jin Hui-Xin , Zhao Na , Wu Yu-Pei , Shi Ying-Qin 
Published: January 2024

BACKGROUND
Glucose imbalance is common in total parenteral nutrition (TPN). Hypoglycemia seems to be less frequent than hyperglycemia, but it influences the clinical outcome to a greater extent. Therefore, it should be effectively prevented and treated. However, there is no relevant report on how to treat hypoglycemia caused by TPN in patients with liver cell injury.
CASE SUMMARY
We present three patients with liver cell injury who developed severe hypoglycemia during or after TPN infusion. The causes of severe hypoglycemia and glucose-raising strategies were discussed. According to the physiological characteristics of the hepatocellular injury, the ratio of nutrition components prescribed in TPN was appropriately adjusted for the three cases. We simultaneously reduced the dose of insulin and fat emulsion, and increased the dose of glucose in TPN. The blood glucose level was restored to normal range and clinical symptoms were eliminated.
CONCLUSION
When hypoglycemia occurs during or after TPN in patients with hepatocellular injury, physicians need to simultaneously reduce insulin and fat emulsion, and increase glucose, and correct severe hypoglycemia in time to reduce its adverse consequences.
Effect of cardiac rehabilitation care after coronary intervention on cardiac function recovery and negative mood in patients with myocardial infarction
Authors: Yang Ming , Huang Yuan-Tao , Hu Xi-Wen , Wu Chun-Ling 
Published: January 2024

BACKGROUND
Cardiovascular disease, particularly myocardial infarction (MI) profound impact on patients' quality of life (QOL) and places a substantial burden on the healthcare and economy systems. Developments in medical technology have led to the emergence of coronary intervention as an essential method for treating MI.
AIM
To assess the effects of cardiac rehabilitation care on cardiac function recovery and negative emotions in MI after coronary intervention.
METHODS
This study included a total of 180 patients with MI during the period from June 2022 to July 2023. Selected patients were divided into two groups: An observation group, which receiving cardiac rehabilitation care; a control group, which receiving conventional care. By comparing multiple observation indicators such as cardiac function indicators, blood pressure, exercise tolerance, occurrence of adverse cardiac events, and negative emotion scores between the two groups of patients. All the data were analyzed and compared between two groups.
RESULTS
There were 44 males and 46 females in the observation group with an average age of 36.26 ± 9.88 yr; there were 43 males and 47 females in the control group, with an average age of 40.87 ± 10.5 yr. After receiving the appropriate postoperative nursing measures, the results of the observation group showed significant improvement in several indicators compared with the control group. Indicators of cardiac function, such as left ventricular end-diastolic internal diameter and left ventricular ejection fraction were significantly better in the observation group than in the control group (P < 0.05). Exercise endurance assessment showed that the 6-minute walking test distance was significantly increased in the patients of the observation group (P < 0.01). In addition, the incidence of adverse cardiac events was significantly lower in the observation group, and negative mood scores were significantly reduced (P < 0.05).
CONCLUSION
Cardiac rehabilitation care after coronary intervention has a significant positive impact on functional recovery. This emphasizes the importance of cardiac rehabilitation care to improve patient recovery.
CHARACTERIZATION OF CLINICAL DATA FOR IN MODERATE OSTEOARTHRITIS WITH SUPPORT VECTOR MACHINES AND REGULATORY NETWORK MODELS
Authors: Segarra-Queralt M. , Galofré M. , Tio L. , Monfort J. , Monllau J.C. , Piella G. , Noailly J. 
Published: January 2024

Knee osteoarthritis (KOA) diagnosis is based on symptoms, assessed through questionnaires such as the WOMAC. However, the inconsistency of pain recording and the discrepancy between joint phenotype and symptoms highlight the need for objective biomarkers in KOA diagnosis. To this end, we study relationships among clinical and molecular data in a cohort of women (n=51) with Kellgren-Lawrence grade 2–3 KOA through Support Vector Machine (SVM) and a regulation network model (RNM). Clinical descriptors (i.e., pain catastrophism (CA); depression (DE); functionality (FU); joint pain (JP); rigidity (RI); sensitization (SE); synovitis (SY)) are used to classify patients. A Youden's test is performed for each classifier to determine optimal binarization thresholds for the descriptors. Thresholds are tested against patient stratification according to baseline WOMAC data from the Osteoarthritis Initiative, and the mean accuracy is 0.97. For our cohort, the data used as SVM inputs are KOA descriptors, synovial fluid (SL) proteomic measurements (n=25), and transcription factors (TF) activation obtained from RNM [2] stimulated with the SL measurements. The relative weights after classification reflect input importance. The performance of each classifier is evaluated through AUC-ROC analysis. The best classifier with clinical data is CA (AUC = 0.9), highly influenced by FU and SE, suggesting that kinesophobia is involved in pain perception. With SL input, leptin strongly influences every classifier, suggesting the importance of low-grade inflammation. When TF are used, the mean AUC is limited to 0.608, which can be related to the pleomorphic behaviour of osteoarthritic chondrocytes. Nevertheless, FU has an AUC of 0.7 with strong importance of FOXO downregulation. Though larger and longitudinal cohorts are needed, this unique combination of SVM and RNM shall help to map objectively KOA descriptors.Acknowledgements: Catalan & Spanish governments 2020FI_b00680; STRATO-PID2021126469ob-C21-2, European Commission (MSCA-TN-ETN-2020-Disc4All-955735, ERC-2021-CoG-O-Health-101044828). ICREA Academia.