bluuebunny/crossref_metadata_2025_split huggingface dataset:
Displacement‐based design procedures for rigid block isolation
Authors: Destro Bisol Giacomo , DeJong Matthew J. , Liberatore Domenico , Sorrentino Luigi 
Published: January 2024

AbstractWhen subjected to earthquakes, many objects or structural elements behave like rocking rigid blocks. Computer servers, medical shelves, art objects, statues, and electrical transformers are frequently included in this category. Protection of these objects is an important task, considering that their value could be inestimable or their operation crucial during earthquakes; base isolation technology has been proven to be a viable option for this purpose. Initially, the dynamic model of a rocking rigid block placed on a base isolation device is reviewed. Then, two equivalent‐static displacement‐based procedures for designing the isolators for these types of objects are proposed, and the main steps are illustrated. The first procedure aims to determine isolator characteristics to prevent the initiation of rocking motion during the code‐level earthquake event. The second procedure is aimed at designing isolators that allow a specified maximum rotation of the block during seismic events. The proposed procedures are validated by means of time‐history analyses for a suite of spectrum‐compatible accelerograms. The first displacement‐based procedure appears particularly suitable for objects of small to medium size. The validation of the second procedure demonstrates that the equal displacement rule can be applied for this kind of systems, despite their softening. The results also indicate that the approach is particularly effective for medium to large structures/objects, if small oscillations are acceptable. The controlled rocking procedure offers a significant advantage by allowing for a reduction in the maximum displacement and period of the isolator, compared to situations where rocking motion must be prevented entirely.
The multifaceted potential of fenugreek seeds: From health benefits to food and nanotechnology applications
Authors: Faisal Zargham , Irfan Rushba , Akram Noor , Manzoor Hafiz Muhammad Irfan , Aabdi Mohib Ali , Anwar Muhammad Junaid , Khawar Sharjeel , Saif Asifa , Shah Yasir Abbas , Afzaal Muhammad , Desta Derese Tamiru 
Published: January 2024

AbstractThe present lifestyle, dietary patterns, psychological pressure, environmental factors, and the widespread exploitation of processed substances in food production and farming have collectively contributed to a substantial expediting in the development of various health problems. Globally, researchers have been seeking natural pharmaceutical substances with the potential to be employed in treating lifestyle‐related diseases or delaying their onset. Fenugreek seeds have gained significant attention in various fields, including health, nutrition, and cutting‐edge nanotechnology applications, due to their versatile qualities. The current investigation offers a comprehensive discussion of the nutritional composition and therapeutic potential of fenugreek seeds, with an emphasis on their plentiful reservoir of bioactive compounds. This seed demonstrates promising medicinal potential in addressing a wide range of health issues. Significantly, these findings indicate noteworthy properties, such as antidiabetic, antioxidant, anti‐obesity, hypocholesterolemic, anticancer, and cardioprotective effects. Moreover, the components of fenugreek seeds are important in the development of a multitude of foods, which is the reason why they are used extensively in the area of food research. In addition to their nutritional value, their exploration of nanotechnology reveals a promising domain, utilizing the distinctive characteristics of seeds for many purposes, such as nanoparticle synthesis and oil for edible films and nanoemulsions. This review article focuses on a comprehensive analysis of fenugreek seeds, examining their wide‐ranging applications in the fields of health, nutrition, food, and nanotechnology.
In‐house virtual surgical planning and guided mandibular reconstruction is less precise, but more economical and time‐efficient than commercial procedures
Authors: Block Ole Moritz , Khromov Tatjana , Hoene Georg , Schliephake Henning , Brockmeyer Phillipp 
Published: January 2024

AbstractBackgroundTo compare an in‐house and a commercially available surgical planning solution for mandibular reconstruction in terms of postoperative reconstruction accuracy and economic benefit.MethodsTwenty‐nine consecutive patients with advanced oral squamous cell carcinoma (OSCC) requiring segmental mandibular reconstruction were enrolled. Fifteen patients underwent in‐house surgical planning and 14 patients underwent a commercially available planning solution. A morphometric comparison of preoperative and postoperative computed tomography (CT) data sets and a cost–benefit comparison were performed.ResultsVolumes of planned and reconstructed bone segments differed significantly for both in‐house planning (p = 0.0431) and commercial planning (p < 0.0001). Significant differences in osteotomy angles were demonstrated for in‐house planning (p = 0.0391). Commercial planning was superior to in‐house planning for total mandibular deviation (p = 0.0217), intersegmental space volumes (p = 0.0035), and lengths (p = 0.0007). No significant difference was found between the two planning solutions in terms of intersegmental ossification and the incidence of wound healing disorders. In‐house planning took less time than commercial planning (p < 0.0001). Component manufacturing costs (p < 0.0001) and total cumulative costs (p < 0.0001) were significantly lower for in‐house planning.ConclusionsIn‐house surgical planning is less accurate but has a cost advantage and could be performed in less time.
Experiences and perspectives of integrating nutrition education into an exercise program for people with chronic medical conditions
Authors: Powter Hannah , Lambert Kelly , Nicholls Natalie 
Published: January 2024

AbstractIssue AddressedCommunity‐based healthy eating and exercise programs are effective interventions to support some people with chronic conditions. This research aimed to explore the experiences and perceptions of participants regarding the integration of nutrition education into a successful group based exercise program for people with chronic medical conditions.MethodsSemi‐structured interviews were conducted with past participants of a community based group exercise program (Health Moves) with embedded nutrition advice based in a regional area of New South Wales. A total of 60 individuals who had participated in the Health Moves program between 2017 and 2019 were invited to participate and 19 (32%) randomly selected participants consented to be interviewed. Interviews explored participants' experiences, program impacts, and barriers to sustaining changes post program. Similar concepts and patterns were grouped into themes.ResultsFour themes were identified that described the experiences with a community‐based group exercise intervention with a nutrition component. The major themes evident were that Health Moves facilitated motivation (via access to health professionals, peer support, accountability, affordability); and there were challenges identified to sustaining change (including cost, comorbidities, end of program support, environmental factors); Nutrition advice was valuable for some but not for all (difficulty recalling nutrition components, superficial coverage) Practical and interactive nutrition advice is desired.ConclusionsParticipants expressed a high degree of satisfaction with the program but require ongoing support to sustain changes post program. The position and integration of nutrition education within this exercise program was perceived by participants to be suboptimal. Increased access to practical, interactive nutrition education components may improve participant satisfaction and engagement.So What?Key findings from this research include a desire for removal of didactic nutrition education sessions and request for increased peer support. Modifications to the program include the integration of interactive self‐paced nutrition modules. Peer support partnerships are now encouraged by trainers to support ongoing motivation of participants to keep training together outside the structured exercise program and transition to managing their own exercise routine. Discussions between organisations involved about ongoing pathway/program support or reduced cost ‘off peak’ gym membership is underway to help with costs incurred by participants.
“Water or not water: That is the question.” Analysis of costs and consumption of the operating theaters in a greener perspective
Authors: Restaino Stefano , Tius Veronica , Arcieri Martina , Biasioli Anna , Pellecchia Giulia , Driul Lorenza , Vizzielli Giuseppe 
Published: January 2024

AbstractObjectiveTo compare the amounts of water and plastic used in surgical hand washing with medicated soaps and with alcohol‐based products and to compare costs and consumption in a year, based on scheduled surgical activity.MethodThis retrospective study was carried out at Udine's Gynecology Operating Block from October to November 2022. We estimated the average amount of water with a graduated cylinder and the total cost of water usage based on euros/m3 indicated by the supplier; for each antiseptic agent we collected the data relevant to wash time, amount of water and product used per scrub, number of handscrubs made with every 500 mL bottle and cost of a single bottle. We put data into two hypothetical contexts, namely WHO guidelines and manufacturers' recommendations. Data were subjected to statistical analysis.ResultsThe daily amount of water using povidone‐iodine, chlorhexidine‐gluconate and alcohol‐based antiseptic agents was 187.6, 140.7 and 0 L/day (P value = 0.001), respectively; A total of 69 000 L/year of water would be saved if alcohol‐based products were routinely used. A single unit of an alcohol‐based product allows three times as many handscrubs as any other product (P value = 0.001) with consequent reduction in plastic packaging.ConclusionDespite the cost saving being negligible, choosing alcohol‐based handrub over medicated soap handrub – on equal antiseptic efficacy grounds ‐ could lead to a significant saving of water and plastic, thus making our operating theaters more environmentally friendly.
Application to nonlinear optical properties of the RSX‐QIDH double‐hybrid range‐separated functional
Authors: Rodríguez‐Mayorga M. , Besalú‐Sala P. , Pérez‐Jiménez Á. J. , Sancho‐García J. C. 
Published: January 2024

AbstractThe effective calculation of static nonlinear optical properties requires a considerably high accuracy at a reasonable computational cost, to tackle challenging organic and inorganic systems acting as precursors and/or active layers of materials in (nano‐)devices. That trade‐off implies to obtain very accurate electronic energies in the presence of externally applied electric fields to consequently obtain static polarizabilities () and hyper‐polarizabilities ( and ). Density functional theory is known to provide an excellent compromise between accuracy and computational cost, which is however largely impeded for these properties without introducing range‐separation techniques. We thus explore here the ability of a modern (double‐hybrid and range‐separated) Range‐Separated eXchange Quadratic Integrand Double‐Hybrid exchange‐correlation functional to compete in accuracy with more costly and/or tuned methods, thanks to its robust and parameter‐free nature.
Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment‐specific detoxification of glyoxylate
Authors: Garrelfs Sander F. , Chornyi Serhii , te Brinke Heleen , Ruiter Jos , Groothoff Jaap , Wanders Ronald J. A. 
Published: January 2024

AbstractGlyoxylate is a key metabolite generated from various precursor substrates in different subcellular compartments including mitochondria, peroxisomes, and the cytosol. The fact that glyoxylate is a good substrate for the ubiquitously expressed enzyme lactate dehydrogenase (LDH) requires the presence of efficient glyoxylate detoxification systems to avoid the formation of oxalate. Furthermore, this detoxification needs to be compartment‐specific since LDH is actively present in multiple subcellular compartments including peroxisomes, mitochondria, and the cytosol. Whereas the identity of these protection systems has been established for both peroxisomes and the cytosol as concluded from the deficiency of alanine glyoxylate aminotransferase (AGT) in primary hyperoxaluria type 1 (PH1) and glyoxylate reductase (GR) in PH2, the glyoxylate protection system in mitochondria has remained less well defined. In this manuscript, we show that the enzyme glyoxylate reductase has a bimodal distribution in human embryonic kidney (HEK293), hepatocellular carcinoma (HepG2), and cervical carcinoma (HeLa) cells and more importantly, in human liver, and is actively present in both the mitochondrial and cytosolic compartments. We conclude that the metabolism of glyoxylate in humans requires the complicated interaction between different subcellular compartments within the cell and discuss the implications for the different primary hyperoxalurias.
One‐step functionalization of paper and simplified antibody immobilization for on‐the‐spot immunocapture from dried serum in liquid chromatography‐tandem mass spectrometry based targeted protein determination
Authors: Mrsa Ago , Nardini Greta , Halvorsen Trine Grønhaug , Thiede Bernd , Reubsaet Léon 
Published: January 2024

AbstractThis work aimed to simplify and improve the process of binding monoclonal antibodies (mAbs) covalently to filter paper for use in dried blood spot sampling, enabling instant capture of protein biomarkers for targeted protein determination. Incorporating the necessary immunocapture sample preparation step in the initial sampling stage saves time and reduces the workload. The biomarker human chorionic gonadotropin (hCG) was used as the model analyte. The antibody‐based paper samplers were prepared by functionalizing paper discs (6 mm) through a simple reaction using divinyl sulfone (DVS). After DVS activation, the paper discs were incubated with E27 hCG mAbs, followed by 0.05% tween/phosphate buffer saline to block the surface. After sample application and drying, the discs only needed to be washed before tryptic digestion and finally analysed on a nanoliquid chromatography–tandem mass spectrometry system. The finished DVS‐mAbs samplers could selectively capture hCG (100 ng/mL) from human serum, with a recovery of 50%. Sample clean‐up reduced the number of identified proteins from 132 to 82 before and after wash, respectively, with a 70% reduction in serum albumin signal while still retaining hCG on the sampler during the washing protocol. An evaluation of the samplers revealed excellent linearity (R2 = 0.9995) for hCG in serum with relative standard deviations below 15%. This work has presented the first ever reported paper samplers immobilized with antibodies utilizing DVS chemistry, showing promise in the future of paper‐based sampling.
Topology property analysis and application of stable time‐delay regions for linear multiple time‐delay systems
Authors: Wang Shaobu , Fan Xiaoyuan 
Published: January 2024

AbstractThis study examines the relationship between the topology of stable time‐delay regions and the stability analysis of an linear multiple time delay system. To analyze the topology of stable time‐delay regions, we construct a function with a value equal to zero for the time‐delay points on the boundaries of stable time‐delay regions. The function is continuous and differentiable in the whole defining field with a global minimum of zero so that we can locate the boundaries by minimizing the value of the function. Based on the topology analysis, we proposed a performance validation approach for controllers that are designed to stabilize the system using feedback signals with time delays. The method based on the topology analysis is simple and reliable so that can deal with a linear time‐invariant system with high order and multiple time delays (more than 3). The example case study shows that the above method is reliable and enables ultra‐low latency coordination and control for the future power grid with ubiquitous power electronics.
A behavioral model for RF vector‐sum phase shifter
Authors: Li Hao , Jin Binjie , Wu Yunqiu , Zhao Chenxi , Yu Yiming , Liu Huihua 
Published: January 2024

AbstractIn this article, a behavioral model for RF vector‐sum phase shifters is developed to estimate their behavioral and guide the phased‐array front‐end system design. According to their building blocks, the model consists of two typical parts, quadrature signal generator and variable gain amplifiers (VGAs). The modeling process for the quadrature signal generator is based on a complex curve fitting method. For the linear VGA, the polynomial fitting method is used to fit the gain and phase responses of the VGA, the first variable is frequency, and the second variable is the control voltage. Then the complex curve fitting method is used to achieve the final frequency response. Finally, the layout simulation results of an actual phase shifter circuit are used as input, and the two modules are modeled and compared with the measured results to verify the usability of the model.
Non‐uniform doping dependent electrical parameters of dual‐metal gate all around junctionless accumulation‐mode nanowire FET (DMGAA‐JAM‐NWFET)
Authors: Gupta Sumedha , Pandey Neeta , Gupta R. S. 
Published: January 2024

AbstractThis paper presents an analytical analysis of a dual‐metal gate all around junctionless accumulation‐mode nanowire FET (DMGAA‐JAM‐NWFET) possessing a horizontal‐like non‐uniform doping profile. The 2‐D electrostatic potential distribution is evaluated using Poisson's equation under the applicable boundary conditions. Also, the impact of straggle length parameter and the peak doping concentration upon the device behavior is also examined. For authenticating the obtained analytical outcomes, TCAD simulations were also performed. Both the results were contrasted and found to be in good agreement. The outcomes obtained for non‐uniform doped DMGAA‐JAM‐NWFET are also compared with that of uniformly doped DMGAA‐JAM‐NWFET and finer electrical characteristics were noticed for non‐uniformly doped device.
Data‐driven model‐free modified nodal analysis circuit solver
Authors: Galetzka Armin , Loukrezis Dimitrios , De Gersem Herbert 
Published: January 2024

AbstractThis work introduces a novel data‐driven model‐free modified nodal analysis (MNA) circuit solver. The solver is capable of handling circuit problems featuring elements for which solely measurement data are available. Rather than utilizing hard‐coded phenomenological model representations, the data‐driven MNA solver reformulates the circuit problem such that the solution is found by minimizing the distance between circuit states that fulfill Kirchhoff's laws, and states belonging to the measurement data. In this way, the formerly inevitable demand for model representations is eliminated, thus avoiding the introduction of related modeling errors and uncertainties. The proposed solver is applied to linear and nonlinear RC‐circuits and to a half‐wave rectifier.
Finite Element Method study on VLF propagable modes coupling and interference in the anisotropic earth‐ionosphere waveguide
Authors: Liu Bing , Wang Maoyan , Zhang Shitian , Li Hailong , Li Guiping , Yu Mengxia , Zhang Xiaochuan , Xu Jun 
Published: January 2024

AbstractIn this paper, the coupled‐mode theory is incorporated into the improved frequency‐domain finite element method (FEM) to simulate very low frequency (VLF) propagable modes coupling and interference in the anisotropic Earth‐ionosphere waveguide. The matrix equation of the electric field is solved using parallel lower‐upper factorization technique to speed up the calculation. The method used to determine the propagation constants for different propagable modes is given. After the FEM is validated by comparing simulated results with the measured data, effects of variable geomagnetic information on the attenuation rate, relative phase velocity, mode coupling, and multiple‐mode interference of VLF electromagnetic wave in the anisotropic waveguide are investigated. This work provides an efficient way for improving the prediction accuracy of the VLF communication, positioning, navigation, and timing systems.
Process Modification and Uncontrollability in an Expert Contemporary Artist's Creative Processes
Authors: Okada Takeshi , Yokochi Sawako 
Published: January 2024

ABSTRACTAs a case study that consists of two parts, this research investigates how a pro‐c class expert artist thinks and acts during art making, paying special attention to exploratory behaviors and task completion processes. In Part 1 of this case study, we videoed an artist's authentic creative process in his studio. We interviewed him about his drawing process by showing him the video recording right after the drawing. We conducted a retrospective interview with him 16 months later as Part 2 of this case study because this experience inspired him to start several new artwork series. We analyzed the video and interview data qualitatively. The results showed that the artist used various exploratory behaviors, including a process modification in which elements in one's ordinary creative process are changed. The process modification triggered different types of drawing actions. Although he participated in task completion processes for self‐regulation, he also actively generated a situation in which task completion processes were weakened to experience and utilize feelings of uncontrollability to create something unexpected. We discussed the essential roles of process modification, reflection, and feelings of uncontrollability in artistic creation.