bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloning and expression of acetaldehyde dehydrogenase from archaea and its application in acrylamide elimination from fried foods
Authors: Xue Luzhou , Chen Wanli , Yu Yiqun , Ni Hao , Hao Yue , Kang Xinxin , Lu Jing , Lyu Mingsheng , Wang Shujun 
Published: February 2024

Abstract

High-temperature frying is a common food processing method, and fried foods are favored by consumers due to its unique flavor and good taste. However, the degradation of unsaturated fatty acids in fats and oils during high-temperature processing results in the production of toxic lipid hydroperoxides (LOPs), saturated and unsaturated aldehydes, as well as acrylamides, which have been classified as group I carcinogens by the International Agency for Research on Cancer (IARC). In this study, high-temperature acetaldehyde dehydrogenase (SufALDH) of marine thermophilic archaeon Sulfolobus tokodaii 7 cloned and expressed. The optimal temperature was 88℃ and the optimal pH was 8.0. The SufALDH enzyme was further used for the pretreatment of fried food, which led to significant reduction in the aldehyde content of the fried food. In SufALDH-treated French fries, fried chicken and fried fish, aldehyde content reduced by 60%, 52% and 33%, respectively, while 40% reduction in acrylamide was observed in the French fries treated with SufALDH. Molecular docking indicated seven key amino acid residues between SufALDH and substrate acetaldehyde, acrolein, acrylamide and isopropyl alcohol, and they will be mutated to improve the SufALDH characteristics for it further application in food industries.
Does redistribution hurt growth? An Empirical Assessment of the Redistribution-Growth Relationship in the European Union
Authors: Christl Michael , Köppl-Turyna Monika , Poli Silvia 
Published: February 2024

Abstract

This paper analyzes the relationship between economic growth, inequality and redistribution. In a cross-country setting for 25 EU countries over the period 2007-2019, we show that market income inequality is associated with higher growth in the short run. To estimate the impact of redistribution to low-income earners, we introduce a new measure, the so-called net benefit share (NBS). Contrary to other findings, we show that this (targeted) redistribution to low-income earners (Q1 NBS) boosts growth in the short run, driven by the consumption and private investment channels. On the other hand, untargeted redistribution to higher income earners reduces growth.
JEL Classification: H23 , O47 , D63
Nursing/Midwifery students’ perceptions of on-line education during COVID-19
Authors: Jones Rikki , Jackson Professor Debra , Rice Kylie , Fisher Associate Professor Murray , Calleja Associate Professor Pauline , Hopkins Martin , West Professor Caryn , Irwin Associate Professor Paulette , McGough Shirley , Luck Associate Professor Lauretta , Walker Felicity , Whiteing Associate Professor Nicola , Usher Professor Kim 
Published: February 2024

Abstract

Aim: This study aimed to gain a better understanding of nursing/midwifery students’ perspectives of the changes to the delivery of undergraduate nursing/midwifery education due to the COVID-19 pandemic, assess whether students perceived a caring pedagogy in their online learning, and investigate whether students’ intention to continue their education and enter the nursing/midwifery workforce has changed due to the pandemic and/or changes in education delivery.
Design: Mixed methods
Methods: A multi-centre cross-sectional survey of Australian nursing and midwifery students were undertaken to explore students experience quantitatively and qualitatively of learning during COIVD-19 pandemic.
Results: There are several key findings from this study that may be relevant for future delivery of undergraduate health education, students transitioning to practice, and health care workforce retention. The study found that although students were somewhat satisfied with online learning during COVID-19, students reported significant issues with knowledge/skill acquisition and barriers to the learning process. The students reported feeling less prepared for practice, and identified how clinical staff were unable to provide additional guidance and support due to increased workloads and stress. The textual responses of participants highlighted that connection/disconnection, empathy and engagement/disengagement had an impact on learning during COVID-19.
Conclusion: This finding suggests the importance of connection alongside the decreasing face to face interactions (for example increased reliance on social media, increasing use of online learning). This study highlights several key findings for consideration in nursing and midwifery education, the profession, and the broader context of healthcare. Graduates entering the workforce post COVID-19 have had to overcome significant barriers to education and clinical placement learning which will have impacted their level of clinical skills, confidence, and ability to practice as new gradate nurses/midwives.
Water resources carrying capacity to achieve a sustainable ecosystem using support vector regression
Authors: Mortezazadeh Feizollah , Pourmohammadi Mohammad Hossein , Khoshnavaz Saeb , Nohani Ebrahim , Eslami Hossein 
Published: February 2024

Abstract
Agricultural water resources carrying capacity has been considered an important problem in recent decades. A comparison of the evaluation indicators of water resources indicated the variation levels of the stability. Machine Learning-Support Vector Regression (ML-SVR) was implemented to formulate the agricultural footprints. The obtained statuses of the water resources have always been characterized by agricultural deficit in the Hendijan plain, Khuzestan province, Iran. Experiments performed outperformed the classical model on both fitted values and the validation value. The results showed that the agricultural footprints from 2010 to 2020 in Iran kept steady with higher levels, while from 2014 to 2016 witnessed a significant decline compared with previous years. The predicted agricultural footprint for the recent 10 years continues to decrease in the semi-arid regions. The predicted results via support vector regression (SVR) showed that agricultural footprints from 2017 to 2020 will present a rising trend, meaning the situation of water crisis will be increasingly serious in the eastern parts of the central deserts.
Advanced Targeted Drug Delivery of Bioactive Agents Fortified with Graft Chitosan in Management of Cancer: A Review
Authors: Begum Rukaiah , Singh Sudarshan , Prajapati Bhupendra , Sumithra M , Patel Ravish J. 
Published: February 2024

Abstract:
Cancer is characterized by the uncontrolled proliferation and spread of abnormal
cells in the body, resulting in the development of tumors or clusters of irregular
cells. The factors contributing to cancer are intricate, involving a combination of genetic,
environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine,
excessive alcohol consumption, exposure to radiation or specific chemicals, and a
family history of the disease. Common treatment methods for cancer encompass
surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy. These
treatments aim to eliminate cancer cells while minimizing harm to healthy cells. Recent
research has extensively explored the potential of bioactive compounds as agents for
combating cancer. However, effectively delivering such compounds to specific target
sites is a complex undertaking. Consequently, there has been widespread exploration of
polymer applications in the development of nanomedicine for delivering bioactive substances.
Additionally, the technique of grafting native excipients onto polymers has been
investigated to enhance their versatility in the delivery of these compounds to specific tumor
cells. This review offers a brief yet informative summary of how grafted chitosan is
employed as a delivery system for bioactive phytopharmaceuticals possessing anticancer
properties. In essence, it delves into the use of grafted chitosan in facilitating the transport
and targeted release of these natural compounds that have demonstrated potential in
combating cancer. This innovative approach has the potential to enhance the effectiveness
of anticancer treatments and minimize their adverse effects on healthy cells.
Exploring the Potential Benefits of Bovine Colostrum Supplementation in the Management of Diabetes and its Complications: A Comprehensive Review
Authors: Chawla Isha , Dhanawat Meenakshi , Sharma Manu , Gupta Sumeet 
Published: February 2024

:
Diabetes is a metabolic illness marked by elevated levels of glucose in the bloodstream
due to the inadequate production or use of insulin in the body. Diabetes can result in a
range of consequences, with the most prevalent being cardiovascular disease, renal failure, vision
loss, and limb removal. Natural compounds isolated from different sources, like colostrum, are
the most important compounds for the treatment of diabetes. Colostrum is a form of lactation
produced by mammals in the first days after giving birth to their offspring, having a rich source
of constituents and showing multipharmacological properties.

:
This review was prepared on the basis of a variety of authoritative search databases, including
Google Scholar, Scopus, and PubMed. In addition, the publications and other online sources
were also included. In the literature search, the terms "colostrum," "diabetes," "uses," "management,"
"constituent," "composition," "alternative sources," "mechanism of action," "preclinical,"
"clinical," "marketed formulations," and "patents" were utilized as keywords and collected from
last two decades.

:
Colostrum has been utilized as a treatment for a wide variety of illnesses due to its active constituents.
A variety of colostrums are available in the market, like goat colostrum, porcine colostrum,
sheep colostrum, human colostrum and many more. They have the full potential of nutrients
like minerals, vitamins, lactose, essential enzymes, proteins and high concentrations of immunoproteins.
Mostly, the colostrums are used for treating diabetes and its complications. Preclinical
and clinical studies of metabolic syndrome, especially on diabetes and its complications,
were also reported at the National and International levels, which evidently prove that the use of
colostrums in the long term can be beneficial for various ailments associated with diabetes.

:
In general, the findings of this review indicate that supplementation with colostrum may hold
promise as a novel therapeutic intervention for people who have diabetes and its complications;
however, additional research is required to fully understand its mechanisms of action and determine
the best possible dosage as well as the time period of supplementation.
Dual-energy CT Portal Venography: Clinical Application Values and Future
Opportunities
Authors: Peng Yu Yang , Yan Jing , Li Yu Ru , Lu Xiao Rui , Wang Lu Yao , Jia Ping Fan , Guo Xing 
Published: February 2024

Abstract:
Standard multidetector computed tomography (MDCT) uses a single X-ray tube to emit a mixed energy X-ray beam, which is received by a single
detector. The difference is that dual-energy CT (DECT), a new equipment in recent years, employs a single X-ray tube or two X-ray tubes to emit
two single-energy X-ray beams, which are received by a single or two detectors. The application of dual-energy technology to portal venography
has become one of the research hotspots. This paper will elaborate on the clinical application values of DECT portal venography in improving
portal vein image quality, distinguishing the nature of portal vein thrombus, reducing contrast agent dose and radiation dose, and will discuss the
possibility of its movement from research to routine practice and future development opportunities.
Qualitative Analysis and Anti-oxidant Potential of Ethanolic Extract ofManilkara zapota (L.) P. Royen Leaves
Authors: Sharma Priyanka , Deep Aakash , Kumar Harish , Chaudhary Devendar , Thakur Neha , Batra Shubham 
Published: February 2024

Background:
The normal metabolic functioning of aerobic cells is related to free
radical formation. The oxygen utilized in the cell growth gives rise to a number of oxygen free
radicals. Further, these oxygen free radicals interact with lipidic molecules to produce hydroxyperoxides
and various other peroxides also, radicals like superoxide, hydroxyls, and lipoid
peroxides, which lead to cytotoxicity due to their interaction with biological systems. The uncontrolled
generation of free radicals may lead to various diseases and disorders like prostate
cancer, coronary heart disease and also ageing. The therapeutic potential of the plant M. zapota
has been demonstrated in various diseases, such as cancers (e.g., breast, prostate, cervical, and
hepatocellular cancer), diabetes mellitus, arthritis, bacterial infections, and gastrointestinal disorders
(e.g., diarrhea and ulcers) and many medical conditions. The main phytocomponents of
this plant are polyphenols, alkaloids, glycosides, flavonoids, saponins, triterpenoids, carbohydrates,
tannins, and sterols.

Objective:
The objective of this study is to investigate qualitative analysis and anti-oxidant potential
of ethanolic extract of Manilkara zapota (L.) P. Royen Leaves. In demand to minimize
the damage caused by free radicals. It is very essential to develop such antioxidants which protect
the body from the effect of free radicals and also do not cause much harm to the human
body. The main phytocomponents of the plant are polyphenols, alkaloids, glycosides, flavonoids,
saponins, triterpenoids, carbohydrates, tannins and sterols which are responsible for antioxidant
activity.

Materials and Methods:
Phytochemical screening methods, Gas chromatography–mass spectrometry
(GC-MS), Fourier transform infrared (FTIR), and Hydrogen Peroxide scavenging assay
for analysis of an ethanolic extract of plant leaves.

Results and Discussion:
Antioxidant activity was determined by a hydrogen peroxide assay.
Plant extract was examined using phytochemical screening, GC-MS analysis, and FTIR spectra.
The plant extract showed hydrogen peroxide scavenging activity (IC50 = 16.45 μg/ml)
compared to the IC50 values of standard ascorbic acid (IC50 = 9.079 μg/ml).

Conclusion:
The present study concluded the antioxidant and phytochemical assessment of the
ethanolic extract of the leaves of Manilkara zapota. The results of the present research study
demonstrated that the antioxidant activity of the plant extract was strong as compared to ascorbic
acid.
Design and Development of Industrial Practice Monitoring and Assessment Systems using Tsukamoto Fuzzy Logic
Authors: Pahtoni Tri Yuli , Arifin Fatchul 
Published: February 2024

Vocational high schools are given flexibility for their students to carry out direct learning in the industry as part of the practical education activities of implementing student skills. The implementation of industrial practice requires a special way to find out and monitor each student's activities so that the achievements of the implementation of industrial practice can be carried out properly. The implementation of industrial work practice assessment has several assessment criteria. These criteria include attendance, neatness, attitude, skills, and knowledge. The problems found in the assessment system are still done manually so that the effectiveness is minimal. This study aims to create a system that can monitor and assess the implementation of industrial practices. The system developed will be tested as a medium for monitoring and assessing industrial practices. This research uses Fuzzy Tsukamoto’s logic approach as a scoring logic model and uses the waterfall method as a development model consisting of analysis, design, coding, and testing. The results of the research conducted resulted in a system that can monitor and assess the implementation of industry practices. The test was carried out by 24 people consisting of guidance teachers and students. Testing is done by testing aspects of functionality and aspects of usability. Based on the test results, the functionality aspect scored 100% (very feasible) and the usage aspect got a score of 84.8% (very feasible)
Peran Moralitas Aparatur Dan Sistem Pelaporan Pelanggaran Dalam Mencegah Kecurangan Dana Desa
Authors: Fadhila Dzikri Ardan , Achmad Tarmizi 
Published: February 2024

Purpose: This study aims to empirically prove the effect of apparatus morality and whistleblowing system on the prevention of village fund fraud.
Methodology/Approach: This study is a quantitative research with primary data sources obtained from distributing questionnaires to respondents. The sampling technique used was purposive sampling technique. The sample of this study consisted of 174 village apparatuses in Pangkah District, Tegal Regency. The analysis technique used to test the hypothesis was multiple linear regression.
Findings: The results showed that apparatus morality and whistleblowing system had a positive effect on the prevention of village fund fraud.
Practical and Theoretical Contribution/Originality: The results of this study are expected to contribute to improving the effectiveness of village fund management against the potential for fraud and also useful as a source of reference for other similar studies.
Research Limitation: The limitation of this study lies in the use of questionnaires as the only method of data collection, which may result in inaccurate answers from respondents. Further research is suggested to add interview methods to deepen the topic under study, as well as reduce potential bias.
Pengembangan Kecerdasan Musikal Anak di Taman Kanak-Kanak Pertiwi 3 Kantor Gubernur Padang
Authors: Indriani Mutiya , Nurhafizah Nurhafizah 
Published: February 2024

This research is carried out every day the implementation of activities carried out in Kindergarten Pertiwi 3 Of the Padang Governor's Office held knock play activities in the classroom so that every day children feel interesting activities and do not get bored for children for the development of children's musical intelligence. This research aims to get an overview of the development of early childhood musical intelligence in Kindergarten Pertiwi 3 Padang Governor's Office. This type of research is qualitative research using a descriptive approach. To see how the development of early childhood musical intelligence in Kindergarten Pertiwi 3 Padang Governor's Office. The subjects of the study were B3-graders at Kindergarten 3 of the Padang Governor's Office. The informant of this study is the principal and teacher in Kindergarten Pertiwi 3 Of the Padang Governor's Office.
Data collection techniques are used in the form of observations, interviews, and documentation. Data analysis techniques are: 1) data collection, 2) data reduction, 3) presentation of data, 4) verification. While the data absorbing technique used in the form of triangulation techniques. The results of the study in general showed that in the development of early childhood musical intelligence in Kindergarten 3 the Governor's Office of Padang teachers has prepared a Daily Learning Implementation Plan (RPPH). Activities carried out every day have been done in accordance with what has been planned, activities carried out every day using various activities such as, playing beats, singing and others. Furthermore, after the child conducts teacher activities to conduct evaluations by means of observation and daily assessment.
Persepsi Siswa Tentang Kelengkapan Fasilitas Perpustakaan di Sekolah Menengah Kejuruan Negeri 3 Padang
Authors: Janata Emilia , Hadiyanto Hadiyanto , Ermita Ermita , Santoso Yulianto 
Published: February 2024

Penelitian ini dilatarbelakangi dari hasil pengamatan peneliti di Sekolah Menengah Kejuruan Negeri 3 Padang, yaitu kelengkapan fasilitas perpustakaan masih kurang. Penelitian ini bertujuan untuk mengetahui kelengkapan fasilitas perpustakaan di Sekolah Menengah Kejuruan Negeri 3 Padang dalam indikator koleksi perpustakaan, gedung dan ruangan perpustakaan, sarana dan prasarana perpustakaan, serta layanan perpustakaan. Permasalahan yang dikaji dalam penelitian ini adalah “Seberapa lengkap fasilitas perpustakaan di Sekolah Menengah Kejuruan Negeri 3 Padang menurut persepsi siswa”. Penelitian ini merupakan penelitian deskriptif kuantitatif. Instrument pengumpulan data menggunakan angket dengan model skala likert. Hasil pengolahan data kelengkapan koleksi perpustakaan memperoleh skor rata-rata 2.99 (kategori lengkap). Kelengkapan gedung dan ruangan perpustakaan memperoleh skor rata-rata 2.90 (kategori memuaskan). Kelengkapan sarana dan prasarana perpustakaan memperoleh skor rata-rata 2.92 (kategori lengkap). Kelengkapan layanan perpustakaan memperoleh skor rata-rata 3.07 (kategori memuaskan). Dapat disimpulkan bahwa kelengkapan fasilitas di Sekolah Menengah Kejuruan Negeri 3 Padang ini berada dalam kategori baik dengan skor rata-rata 3.07. Berdasarkan hasil penelitian tersebut, penulis menyarankan agar kelengkapan fasilitas perpustakaan di SMK Negeri 3 Padang dapat dipertahankan dan ditingkatkan lagi sehingga perpustakaan menjadi tempat yang nyaman bagi siswa di sekolah.
Penerapan Kurikulum Merdeka Belajar di SMK Negeri 9 Padang
Authors: Sri Devi Putri Kumtum , Jasrial Jasrial , Adi Nelfia , Achyar Novriyanti 
Published: February 2024

Penelitian ini dilatarbelakangi oleh permasalahan-permasalahan yang ditemukan pada penerapan kurikulum merdeka belajar di SMK Negeri 9 Padang. Penelitian ini bertujuan untuk menggali informasi tentang penerapan kurikuum merdeka belajar di SMK Negeri 9 Padang dilihat dari Rencana Pelaksanaan Pembelajaran (RPP), Bahan Ajar, Perangkat Pembelajaran, Evaluasi Pembelajaran, dan Laporan Hasil Belajar siswa. Jenis penelitian ini bersifat deskriptif. Populasi dalam penelitian ini adalah seluruh guru SMK Negeri 9 Padang yang berjumlah 75 orang, maka penelitian ini adalah penelitian populasi. Instrument dalam penelitian ini adalah angket model skala likert dengan lima pilihan jawaban, yaitu Sangat Baik (SB), Baik (B), Cukup Baik (CB), Kurang Baik (KB), dan Tidak Baik (TB). Angket penelitian ini telah diuji validitas dan reliabilitasnya, selanjutnya data diolah dengan rumus rata-rata (mean). Hasil penelitian menyatakan bahawa penerapan kurikulum merdeka belajar di SMK Negeri 9 Padang dilihat dari 1) rencana pelaksanaan pembelajaran (RPP) dengan skor rata-rata 4,79 berada pada kategori sangat baik, 2) bahan ajar dengan skor rata-rata 4,76 berada pada kategori sangat baik, 3) perangkat pembelajaran dengan skor rata-rata 4,84 berada pada kategori sangat baik. 4) evaluasi pembelajaran dengan skor rata-rata 4,76 berada pada kategori sangat baik, 5) laporan hasil belajar siswa dengan skor rata-rata 4,8 berada pada kategori sangat baik. Dengan demikian dapat disimpulkan bahwa penerapan kurikulum merdeka belajar di SMK Negeri 9 Padang berada pada kategori sangat baik dengan skor rata-rata 4,79.