bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Ketahanan Baterai Lithium Ion pada Sepeda Listrik Roda Tiga
Authors: Dewi Dewi lestari , Susilo Susilo , Widodo Bambang 
Published: November 2023

Baterai litium-ion (Li-Ion) adalah baterai isi ulang yang digunakan untuk menyimpan dan menyediakan energi elektrokimia. Tujuan penelitian ini untuk mengetahui ketahanan baterai lithium-ion pada sepeda listrik roda tiga. Metode penelitian yang digunakan menggunakan metode deskriptif kuantitatif. Ketahanan baterai lithium-ion pada sepeda listrik selama pemakaian (discharge) bervariasi tergantung pada intensitas penggunaan. Pemakaian tanpa beban cenderung lebih tahan lama, sementara penggunaan dengan beban berat mengurangi masa tahan baterai. Terlihat pada hasil presentase pemakaian awal tegangan baterai lithium ion 64,1 v kemudian setelah 5 menit pemakaian mengalami penurunan baterai menjadi 62,8 v begitu seterusnya dengan efisiensi waktu yang bevariasi. Sedangkan pada pemakaian awal baterai dengan pembebanan 42 kg dengan tegangan baterai 64,1 v, kemudian selama pemakaian 5 menit mengalami penurunan baterai menjadi 51,3 v, Pembebanan 53 kg dengan tegangan baterai 64 v selama pemakaian 5 menit baterai mengalami penurunan menjadi 53 v dan pembebanan 56 kg baterai mempunyai tegangan 64,4 v selama 5 menit mengalami penurunan menjadi 54,9 v begitu seterusnya dengan efisiensi waktu yang bevariasi. Faktor ini perlu dipertimbangkan untuk menjaga performa dan umur baterai dan kapasitas baterai lithium-ion pada sepeda listrik roda tiga dapat mengalami perubahan selama siklus pengisian ulang. Pada awalnya, setelah pengisian penuh, kapasitas baterai akan maksimal. Namun, setiap kali baterai diisi ulang dan digunakan, terjadi perubahan kimia dalam sel baterai yang dapat mengakibatkan penurunan kapasitas seiring berjalannya waktu dan jumlah siklus pengisian ulang.
Perancangan Pembangkit Listrik Mikrohidro 30 Kw Untuk Suplai Listrik Area Wisata di Desa Girimulyo Ngargoyoso, Karang Anyar, Jawa Tengah
Authors: Leksana Ridwan , Widodo Bambang , Silalahi Eva Magdalena , Nempung Judo Ignatius 
Published: November 2023

describe a power plant that employs the flow of water as its source of propulsion. An investigation must be
conducted on the subject, specifically water, in order to gain an understanding of its potential prior to
beginning the design process for a micro hydro producing unit.
The micro hydro power plant in the village of Girimulyo serves as both a source of electricity and a popular
tourist and educational destination for the community. Data were gathered from the observations, including the
water discharge (Q=0.2 m3/s) and the head/height of falling water (H=22.09 m).
obtaining information depending on flow rate and heightof the falling water may already be determined,
allowing the Pelton type Micro Hydro turbine to be selected as the drive unit. whereas the 30kW turbine is
intended to produce electricity. The major parts of the Pelton type turbine were constructed with wheel
diameter D = 448mm, number of nozzles 2, shaft diameter d = 38mm, and gearbox based on the results of the
data obtained. flat belt having a 1:1 transmission ratio.
Analisa Harmonisa Dan Simulasi Filter Aktif Shunt Pada Base Transceiver Station (BTS) Di Gedung Prodi Teknik Mesin Fakultas Teknik Universitas Kristen Indonesia (UKI) Jakarta Menggunakan Matlab Simulink
Authors: Nai David Melanius , Silalahi Eva Magdalena , Purba Robinson 
Published: November 2023

Di era modern ini elektronika daya banyak digunakan dalam peralatan listrik yang cenderung bersifat tidak linear, mengakibatkan gelombang arus tidak sama dengan gelombang tegangan. Penelitian ini bertujuan untuk mengetahui harmonisa yang ditimbulkan oleh BTS yang mencakup tingkat distorsi harmonisa tegangan dan arus akibat pemakain energi listrik pada BTS. Penelitian dilakukan terhadap BTS di Gedung Program Studi Teknik Mesin Fakultas Teknik UKI, Jakarta. Berdasarkan penelitian yang dilakukan pada BTS ditemukan bahwa Total Harmonic Distortion Voltage (THDV) untuk fasa R, S dan T sebesar 1,62%, 1,39% dan 1,34% yang masih memenuhi standar IEEE 519-2014, sedangkan nilai Total Harmonic Distortion Current (THDI) untuk fasa R, S dan T sebesar 6,20%, 5,93% dan 5,57% yang tidak memenuhi standar IEEE 519-2014,dengan harmonisa dominan terjadi pada orde ke-3. Berdasarkan hasil simulasi rancangan filter aktif shunt menggunakan matlab, diperoleh nilai THDI sesudah menggunakan filter aktif shunt untuk fasa R, S dan T bernilai 0,15%, 0,68% dan 0,59% yang telah memenuhi standar IEEE 519-2014, serta nilai harmonisa arus dominan menunjukan bahwa orde ke-3 juga memenuhi standar IEEE 519-2014, dengan tingkat harmonisa sebesar 0,01%, 0% dan 0,01% untuk fasa R, S, dan T
Analisa Harmonisa Transformator Satu Fasa Berbeban Motor Arus Searah Melalui Rectifier Dan Simulasi Filter Pasif Berbasis MATLAB Di Laboratorium Program Studi Teknik Elektro Fakultas Teknik Universitas Kristen Indonesia
Authors: Dangin Helda Oktavianti , Silalahi Eva Magdalena , Purba Robinson 
Published: November 2023

Penelitian ini menganalisis harmonisa transformator satu fasa yang dibebani dengan Motor Arus Searah (MAS) dan penyearah dengan menggunakan pendekatan metode kuantitatif. Tujuan dari penelitian ini adalah untuk mengidentifikasi nilai Total Harmonic Distortion untuk arus (THDi) pada transformator dan merancang filter pasif guna mengurangi tingkat harmonisa apabila tidak memenuhi standar. Hasil penelitian menunjukkan bahwa hasil pengukuran, diperoleh THDi 31,01% pada transformator beban nol, pada transformator dengan beban MAS dengan penyearah setengah gelombang, THDi sebesar 79,35%, dan pada transformator berbeban MAS dengan penyearah gelombang penuh, THDi sebesar 46,40%, yang melebihi standar IEEE 519-2014. Hasil simulasi filter pasif single tuned LC menunjukkan bahwa pada transformator berbeban MAS dengan penyearah setengah gelombang mengalami penurunan tingkat harmonisa dari nilai THDi 79,35% sebelum menggunakan filter, menjadi 1,04% setelah menggunakan filter dan memenuhi standar IEEE 519-2014. Tingkat harmonisa dari transformator berbeban MAS dengan penyearah gelombang penuh, sebelum difilter, THDi 46,40%, namun setelah difilter, THDi 37,98%, masih melebihi standar IEEE 519-2014.
Clinical features and outcomes of in-hospital cardiac arrest in code blue events: a retrospective observational study
Authors: Akatsuka Masayuki , Tatsumi Hiroomi , Masuda Yoshiki 
Published: November 2023

BackgroundIn-hospital cardiac arrest (IHCA) is a critical medical event with outcomes less researched compared to out-of-hospital cardiac arrest. This retrospective observational study aimed to investigate key aspects of IHCA epidemiology and prognosis in patients with Code Blue activation.MethodsThis retrospective observational study enrolled patients with Code Blue events in our hospital between January 2010 and October 2019. Participant characteristics, including age and sex, and IHCA characteristics, including the time of cardiac arrest, witnessed event, bystander cardiopulmonary resuscitation (CPR), initial shockable rhythm, vital signs at 1 and 6 h before IHCA, survival to hospital discharge (SHD), and the cardiac arrest survival postresuscitation in-hospital (CASPRI) score were included in univariate and multivariate logistic regression analyses with SHD as the primary endpoint.ResultsFrom the 293 Code Blue events that were activated during the study period, 81 participants were enrolled. Overall, the SHD rate was 28.4%, the median CPR duration was 14 (interquartile range, 6–28) min, and the rate of initial shockable rhythm was 19.8%. There were significant intergroup differences between the SHD and non-SHD groups in the CPR duration, shockable rhythm, and CASPRI score on univariate logistic regression analysis. Multivariate logistic regression analysis showed that the CASPRI score was the most accurate predictive factor for SHD (OR = 0.98, p = 0.006).ConclusionsThe CASPRI score is associated with SHD in patients with IHCA during Code Blue events. Therefore, the CASPRI score of IHCA patients potentially constitutes a simple, useful adjunctive tool for the management of post-cardiac arrest syndrome.
Thermal and entropy behavior of sustainable solar energy in water solar collectors due to non-Newtonian power-law hybrid nanofluids
Authors: Mabrouk S. M. , Mahmoud Tarek A. , Kabeel A. E. , Rashed A. S. , Essa Fadl A. 
Published: November 2023

Introduction: Nanofluids, hybrid nanofluid possesses thermophysical features that boost the fluid performance. This research work is motivated by the utilization of water solar collectors that incorporate non-Newtonian, power-law hybrid nanofluid in a three-dimensional model, considering the two-phase model.Method: The primary objective of this study is to transform the governing equations of the flow model into a set of ordinary differential equations by employing the three-parameters group technique. Based on the innovative discoveries, two models incorporating new associated functions have been successfully developed for two distinct scenarios characterized by the power-law index, n. The impact of physical factors on the velocity profile, temperature distribution, concentration field, and entropy output of the system is clearly illustrated through a variety of graphs.Results: The results indicated that the inclination angle of 20° had the best thermal characteristics compared to other inclinations. The entropy generation reached its maximum value at temperature difference of 13 K due to irreversibility of the system, which indicates that the system is more efficient.Discussion: Furthermore, the increasing percentage in Nusselt number is predicted to be 28.18% when the Prandtl number is taken a range. The Sherwood number enhanced up to 18.61% with a range of Brownian motion. A quantitative comparison is conducted between the present results and the literature in order to validate the superior efficiency of the used method.
Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation
Authors: Umar Ayesha , Barkat Kashif , Hussain Shah Syed Nisar , Ashraf Muhammad Umer , Badshah Syed Faisal , Ali Akhtar , Anjum Irfan , Bin Jardan Yousef A. , Nafidi Hiba-Allah , Dauelbait Musaab , Bourhia Mohammed 
Published: November 2023

Solubility is one of the major factors which affects several therapeutic mioeties in terms of their therapeutic efficacy. In the current study, we presented a porous and amorphous nanometrices system for the enhancement of the solubility of acyclovir. The polymeric network was fabricated by crosslinking polyethylene glycol-6000, polycaprolactone, and β-cyclodextrin with methacrylic acid by optimizing free radical polymerization technique using methylene bisacrylamide as a crosslinking agent. The formulated nanometrices were then characterized by zetasizer, FTIR, PXRD, Scanning electron microscopy, Thermogravimetric analysis, swelling, sol-gel fraction, drug loading, stability, solubility, and in-vitro dissolution analysis. Since the formulated system has to be administered orally, therefore to determine the in-vivo biocompatibility, nanometrices were administered orally to experimental animals. SEM images provided a rough and porous structure while PXRD showed an amorphous diffractogram of the unloaded and loaded nanometrices. Moreover, the particle size of the optimum loaded formulation was 25 nm higher than unloaded nanometrices due to the repulsion of the loaded drug. A significant loading of the drug with enhanced solubility and dissolution profiles was observed for the poorly soluble drug. The dissolution profile was quite satisfactory as compared to the marketed brand of drug which depicted that the solubility of the drug has been enhanced. Toxicity study conducted on rabbits confirmed the biocompatibility of the nanometrices. The systematic method of preparation, enhanced solubility and high dissolution profile of the formulated nanometrices may be proved as a promising technique to enhance the solubility of poorly aqueous soluble therapeutic agents.
Association between the peripheral neutrophil-to-lymphocyte ratio and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes
Authors: Zhu Nan , Song Yongfeng , Zhang Chen , Wang Kai , Han Junming 
Published: November 2023

BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes frequently co-occur, imposing a tremendous medical burden. A convenient and effective MASLD indicator will be beneficial to the early diagnosis of disease. In the clinical laboratory, the neutrophil-to-lymphocyte ratio (NLR) is a readily accessible hematological marker. This study designed to determine the relation between the NLR and MASLD in type 2 diabetes patients.MethodsData from 1,151 type 2 diabetes inpatients without infections, malignancy or hematological diseases who were recruited from 2016 through 2022 were analyzed in the retrospective study. The patients were stratified into NLR tertiles (total population: high NLR level &gt; 2.18; middle NLR level: 1.58–2.18; low NLR level &lt; 1.58), with additional subgroup stratification by sex (men: high NLR level &gt; 2.21; middle NLR level: 1.60–2.21; and low NLR level &lt; 1.60; women: high NLR level &gt; 2.12; middle NLR level: 1.53–2.12; and low NLR level &lt; 1.53). After adjusting for confounders (age, sex, weight, Glu, ALT and TG) associated with MASLD, the odds ratio (OR) and the corresponding 95% confidence interval (CI) of the NLR were obtained by using a binary logistic regression analysis to verify the correlation between the NLR and MASLD.ResultsCompared to non-MASLD patients, MASLD patients had higher weight, blood glucose, insulin and C-peptide, worse liver function (higher ALT and GGT), lower HDL (all p &lt; 0.05), and lower NLR (p &lt; 0.001). The prevalence of MASLD was 43.75% (high NLR level), 55.21% (middle NLR level) and 52.22% (low NLR level) (p &lt; 0.05). Compared to those of the high NLR level, the adjusted ORs and 95% CIs of the middle and low NLR levels were 1.624 (95% CI: 1.141–2.311) and 1.456 (95% CI: 1.025–2.068), for all subjects, while they were 1.640 (95% CI: 1.000–2.689) and 1.685 (95% CI: 1.026–2.766), for men.ConclusionA low NLR is associated with a greater risk of MASLD.
Pseudorabies gD protein protects mice and piglets against lethal doses of pseudorabies virus
Authors: Zhao Mengpo , Chen Jing , Luo Shengjun , Yan Renhe , Zhang Pian , Ren Zhaowen , Chen Xiaofan , Wang Gang , Xiang Hua , Cai Rujian , Huang Yuan , Li Na , Li Hongwei , Yuan Zi-Guo , Wang Xiaohu 
Published: November 2023

IntroductionPseudorabies (PR) is a highly contagious viral disease caused by the pseudorabies virus (PRV), which can cause disease in a wide range of domestic and wild animals. Studies have shown that new mutant strains have emerged in pig farms in many regions and that commercial inactivated and live attenuated vaccines are becoming less effective at protecting pigs.MethodsPorcine pseudorabies glycoprotein D (gD) gene (GenBank: QEY95774.1) with hexa-His tag to the C terminus for further purification processes was cloned into the lentiviral expression plasmid pLV-CMV-eGFP by restriction enzyme, the resulting plasmid was designated as pLV-CMV-gD. HEK-293T cells with robust and stable expression of recombinant gD protein was established by infection with recombinant lentivirus vector pLV-CMV-gD. We expressed porcine pseudorabies virus gD protein using HEK-293T cells.ResultsWe describe in this study that individual gD proteins produced by a mammalian cell expression system are well immunogenic and stimulate high levels of PRV-specific and neutralizing antibodies in mice and piglets. All mice and piglets survived lethal doses of PRV, significantly reducing the amount of PRV virus in piglets’ lymph nodes, lungs, spleen, and other tissues. It also significantly reduced the time cycle and amount of viral excretion from piglets to the environment through the nasal and anal cavities.DiscussionThe results suggest that PRV gD protein is expected to be a potential candidate for the preparation of genetically engineered PR vaccines for the prevention of PRV infection and the control of PR epidemics.
The efficacy and safety of anti-Aβ agents for delaying cognitive decline in Alzheimer’s disease: a meta-analysis
Authors: Li Jiaxuan , Wu Xin , Tan Xin , Wang Shixin , Qu Ruisi , Wu Xiaofeng , Chen Zhouqing , Wang Zhong , Chen Gang 
Published: November 2023

BackgroundThis meta-analysis evaluates the efficacy and safety of amyloid-β (Aβ) targeted therapies for delaying cognitive deterioration in Alzheimer’s disease (AD).MethodsPubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov were systematically searched to identify relevant studies published before January 18, 2023.ResultsWe pooled 33,689 participants from 42 studies. The meta-analysis showed no difference between anti-Aβ drugs and placebo in the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog), and anti-Aβ drugs were associated with a high risk of adverse events [ADAS-Cog: MDs = −0.08 (−0.32 to 0.15), p = 0.4785; AEs: RR = 1.07 (1.02 to 1.11), p = 0.0014]. Monoclonal antibodies outperformed the placebo in delaying cognitive deterioration as measured by ADAS-Cog, Clinical Dementia Rating–Sum of Boxes (CDR-SB), Mini-Mental State Examination (MMSE) and Alzheimer’s Disease Cooperative Study–Activities of Daily Living (ADCS-ADL), without increasing the risk of adverse events [ADAS-Cog: MDs = −0.55 (−0.89 to 0.21), p = 0.001; CDR-SB: MDs = −0.19 (−0.29 to −0.10), p &lt; 0.0001; MMSE: MDs = 0.19 (0.00 to 0.39), p = 0.05; ADCS-ADL: MDs = 1.26 (0.84 to 1.68), p &lt; 0.00001]. Intravenous immunoglobulin and γ-secretase modulators (GSM) increased cognitive decline in CDR-SB [MDs = 0.45 (0.17 to 0.74), p = 0.002], but had acceptable safety profiles in AD patients. γ-secretase inhibitors (GSI) increased cognitive decline in ADAS-Cog, and also in MMSE and ADCS-ADL. BACE-1 inhibitors aggravated cognitive deterioration in the outcome of the Neuropsychiatric Inventory (NPI). GSI and BACE-1 inhibitors caused safety concerns. No evidence indicates active Aβ immunotherapy, MPAC, or tramiprosate have effects on cognitive function and tramiprosate is associated with serious adverse events.ConclusionCurrent evidence does not show that anti-Aβ drugs have an effect on cognitive performance in AD patients. However, monoclonal antibodies can delay cognitive decline in AD. Development of other types of anti-Aβ drugs should be cautious.Systematic Review RegistrationPROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42023391596.
A 12-week lifestyle intervention: effects on fatigue, fear, and nutritional status in children with a Fontan circulation
Authors: Scheffers L. E. , Helbing W. A. , Pereira T. , Walet S. , Utens E. M. W. J. , Dulfer K. , van den Berg L. E. 
Published: November 2023

IntroductionChildren and adolescents with a Fontan circulation are less physically active compared to healthy peers. In the current study, effects of a 12-week lifestyle intervention on fatigue, fears regarding exercise, caloric intake, rest energy expenditure (REE), and body composition were measured in children with a Fontan circulation.MethodsThis study was a semi-cross-over randomized controlled trial. The lifestyle intervention consisted of a 12-week high-weight resistance training (three supervised training sessions a week) supported by high-protein diet (&gt;2 g/kg) and tailored recommended caloric intake. Fatigue (measured by the validated PedsQol Multidimensional Fatigue Scale), fears regarding exercise (measured on a fear thermometer), REE (measured using indirect calorimetry), caloric intake and body composition using air displacement plethysmography, and four-skinfold method were measured before and after the intervention and control period.ResultsTwenty-seven pediatric Fontan patients, median age 12.9 years (IQR: 10.5–16.2), of the included 28 patients successfully completed the program. Before training, both child- and parent-reported levels of fatigue were significantly worse on all domains (general, sleep/rest, and cognitive fatigue) compared to healthy peers. After training, parent-reported fatigue significantly improved on the general and cognitive fatigue domains [effect size +16 points (7–25), p &lt; 0.001, and +10 points (2–17), p = 0.015, compared to the control period]. Before training, fear regarding exercise scored on the fear thermometer was low for both children and parents (median score 1 and 2, respectively, on a scale of 0–8). After training, child-reported fear decreased further compared to the control period [effect size −1.4 points (−2.3 to −0.6), p = 0.001]. At baseline, children had increased REE +12% compared to reference values, which did not change after exercise. Children ate an average of 637 calories below recommended intake based on REE, caloric deficit became smaller after the intervention, and protein intake increased compared to the control period [−388 calories (−674 to −102), p = 0.008, and +15 g (0.4–30), p = 0.044]. Body fat percentage did not change significantly.ConclusionA 12-week lifestyle intervention improved parent-reported fatigue symptoms in the children, further decreased child-reported fears, and increased caloric and protein intake.
Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review
Authors: Cao Qiang , Wu Xinyan , Zhang Qi , Gong Junling , Chen Yuquan , You Yanwei , Shen Jun , Qiang Yi , Cao Guangzhu 
Published: November 2023

Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma (MM). Over the years, BCL-2, a crucial anti-apoptotic protein, has garnered significant attention in MM therapeutic research. Venetoclax (VTC), a small-molecule targeted agent, effectively inhibits BCL-2, promoting the programmed death of cancerous cells. While VTC has been employed to treat various hematological malignancies, its particular efficacy in MM has showcased its potential for broader clinical applications. In this review, we delve into the intricacies of how VTC modulates apoptosis in MM cells by targeting BCL-2 and the overarching influence of the BCL-2 protein family in MM apoptosis regulation. Our findings highlight the nuanced interplay between VTC, BCL-2, and MM, offering insights that may pave the way for optimizing therapeutic strategies. Through this comprehensive analysis, we aim to lay a solid groundwork for future explorations into VTC’s clinical applications and the profound effects of BCL-2 on cellular apoptosis.
Towards a compact all-optical terahertz-driven electron source
Authors: Xu Hanxun , Li Renkai , Yan Lixin , Du Yingchao , Tian Qili , Huang Wenhui , Tang Chuanxiang 
Published: November 2023

In this study, we propose a physical design of a compact all-optical terahertz (THz)-driven electron source. The 300-mm accelerator beamline, powered by a Joule-level laser system, can be easily integrated into the tabletop scale. A THz-driven electron gun, a tapered dielectric-loaded cylindrical waveguide, THz-driven bunch compressors, and permanent magnetic solenoids (PMSs) have been designed and optimized. Dynamic simulations show that the electron source can deliver 19 fC electron beams at 3 MeV, with a normalized transverse emittance of 0.079 π.mm.mrad. A minimum relative energy spread of 0.04% or a minimum root-mean-square (RMS) bunch length of 6.1 fs can be achieved. Sensitivity analysis shows that the THz-driven electron source can effectively work with a laser power jitter within 1.5%. Simulation studies also reveal the potential of the designed THz-driven electron source for achieving high-quality ultrafast electron diffraction (UED). Prototype THz-driven electron guns have been fabricated and are currently under testing, and more comprehensive results will be reported in future works.