bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental Health Symptoms in Parents of Infants 3 Months After Discharge Following Neonatal Cardiac Surgery
Authors: Lisanti Amy J. , Quinn Ryan , Chittams Jesse L. , Laubacher Megan , Medoff-Cooper Barbara , Demianczyk Abigail C. 
Published: January 2024

Background
Parents of newborns with congenital heart disease (CHD) are at risk for anxiety, depression, and post-traumatic stress. Few studies have examined whether modifiable factors that influence parents’ mental health after discharge are present during postoperative care in the pediatric cardiac intensive care unit (PCICU).

Objective
To describe mental health symptoms of parents of infants with CHD 3 months after PCICU discharge and to determine factors during the PCICU stay that are predictors of such symptoms.

Methods
A longitudinal cohort pilot study of 56 parents (28 mother-father dyads) of 28 infants with CHD. During the first postoperative week after cardiac surgery, parents completed questionnaires measuring factors potentially influencing mental health. Three months after discharge, 42 parents of 22 infants completed validated measures of anxiety, depression, and posttraumatic stress.

Results
Three months after discharge, 26% of parents had clinically elevated levels of anxiety symptoms, 21% had clinically significant levels of depressive symptoms, and 19% had posttraumatic stress symptoms. In multi-variable analysis, parental role alteration in the PCICU was predictive of anxiety (P = .002), depressive (P = .02), and posttraumatic stress (P = .02) symptoms 3 months after discharge. Higher education level was predictive of anxiety symptoms (P = .009). Postnatal CHD diagnosis was predictive of posttraumatic stress symptoms (P = .04).

Conclusions
Parental role alteration perceived by parents during the PCICU stay is a modifiable stressor contributing to adverse mental health symptoms 3 months after discharge. Interventions targeting parental role alteration in the PCICU are critically needed.
Association of Lack of Fear of Dying With New Organ Failure: Results of a Multicenter Prospective Cohort Study
Authors: Mazeraud Aurélien , Turc Guillaume , Sivanandamoorthy Sivanthiny , Porcher Raphaël , Stoclin Annabelle , Antona Marion , Polito Andrea , Righy Cassia , Bozza Fernando A. B. , Siami Shidasp , Sharshar Tarek 
Published: January 2024

Background
Patients’ anxiety on intensive care unit (ICU) admission is associated with subsequent deterioration.

Objective
To assess whether patients’ fears/anxiety are predictive of new organ failure within 7 days of ICU admission.

Methods
In a prospective 3-center cohort study of non-comatose patients without delirium or invasive mechanical ventilation, 9 specific fears were evaluated through yes/no questions. Illness severity was assessed using the Simplified Acute Physiology Score II (SAPS II) and the Sequential Organ Failure Assessment (SOFA). Intensity of acute and chronic anxiety was assessed with the state and trait components of the State-Trait Anxiety Inventory (STAI). Patients were followed up for 7 days.

Results
From April 2014 to December 2017, 373 patients (median [IQR] age, 63 [48-74] years; 152 [40.8%] women; median (IQR) SAPS II, 27 [19-37]) were included. Feelings of vulnerability and fear of dying were reported by 203 (54.4%) and 172 (46.1%) patients, respectively. The STAI-State score was 40 or greater in 192 patients (51.5%). Ninety-four patients (25.2%) had new organ failure. Feelings of vulnerability (odds ratio, 1.96 [95% CI, 1.12-3.43]; P=.02) and absence of fear of dying (odds ratio, 2.38 [95% CI, 1.37-4.17]; P=.002) were associated with new organ failure after adjustment for STAI-State score (≥40), SAPS II, and SOFA score.

Conclusion
Absence of fear of dying is associated with new organ failure within the first 7 days after ICU admission. Fear of dying may protect against subsequent deterioration by mobilizing patients’ homeostatic resources. ClinicalTrials.gov Identifier: NCT02355626
HAPLOIDENTICAL TRANSPLANT WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE FOR ACUTE MYELOID LEUKAEMIA AND MYELODYSPLASTIC SYNDROMES PATIENTS: THE ROLE OF PREVIOUS LINES OF THERAPY.
Authors: Avenoso Daniele , Serpenti Fabio , Barnea Slonim Liron , Bouziana Styliani , Dazzi Francesco , Hannah Guy , Kenyon Michelle , Mehra Varun , Kulasekararaj Austin , Krishnamurthy Pramila , Naresh Shah Mili , Lionel Sharon , Pagliuca Antonio , Potter Victoria 
Published: January 2024

Background: Allogeneic haematopoietic stem-cell transplant is a potentially curative option for high-risk acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Post-transplant cyclophosphamide administration allows for selection of haploidentical donors in patients who are eligible for the procedure, but do not have a fully matched donor, since it can overcome the HLA barrier. There is still an active debate on whether intensification of the conditioning regimen is necessary with haploidentical donors when peripheral blood stem cells are used as the source of the graft.
Herein we report our decennial experience of haploidentical stem-cell transplant using peripheral blood stem cells at King’s College Hospital.
Objectives: The primary objective was to evaluate overall survival (OS) for patients with less than two previous lines of therapy. Secondary objectives were total OS, OS according to cytomegalovirus (CMV) reactivation, incidence of transplant-related mortality (TRM), graft-versus-host disease (GVHD) and GVHD-relapse-free survival (GRFS).
Results: One-year and three-year total OS were 62% and 43%, respectively, with a median OS of 22 months. One-year and three-year OS for patients with ≤2 and in patients with >2 previous lines of therapy were 72% and 55%, and 60% and 22%, respectively (p-value=0.04). The median OS in patients with >2 previous lines of therapy and ≤2 lines of therapy was 16 and 49 months, respectively. Cumulative incidence (CI) of relapse was 25% with a median time to relapse of 5 months (range 1 – 38 months).
Conclusions: Haploidentical haematopoietic stem-cell transplant is potentially curative in chemo-sensitive AML and MDS and offers a high rate of prolonged remission. Our cohort further confirms the role of consolidative haploidentical transplant in patients in complete remission and highlights that patients with heavily pre-treated disease may not benefit from this strategy.
SAFETY OF BRONCHOALVEOLAR LAVAGE IN HEMATOLOGICAL PATIENTS WITH THROMBOCYTOPENIA – A RETROSPECTIVE COHORT STUDY
Authors: GUR Ivan , Tounek Roei , Dotan Yaniv , Vainer Evgrafov Elite , Rakedzon Stav , Fuchs Eyal 
Published: January 2024

Background
Hospitalized hematological patients often require bronchoalveolar lavage (BAL). Paucity of evidence exists as to the potential risks in patients with very-severe thrombocytopenia (VST).
Methods
This retrospective-cohort study included adult hematological in-patients with VST, defined as platelets<20x103/μL, undergoing BAL during 2012-2021. Mechanically-ventilated patients or those with known active bleeding were excluded. Primary outcomes included major bleeding halting the BAL or deemed significant by the treating physician, need for any respiratory support other than low flow O2 or death within 24 hours. Any other bleeding were recorded as secondary outcomes.
Results
Of the 507 patients included in the final analysis, the 281 patients with VST had lower hemoglobin (Md=0.3, p=0.003), longer prothrombin-time (Md=0.7s, p=0.025), higher chances of preprocedural platelet transfusion (RR 3.68, 95%CI[2.86,4.73]), and only one primary-outcome event (death of septic shock 21h postprocedurally) - compared with 3 (1.3%) events (two bleedings halting procedure and one need for non-invasive-ventilation) in patients with platelets ≥20x103/μL (p=0.219). Risk of minor, spontaneously resolved bleeding was higher (RR=3.217, 95%CI[0.919,11.262]) in patients with VST (4.3% vs 1.3%, p=0.051). No association was found between any of the complications recorded and preprocedural platelets, age, aPTT, PT, hematological status, or platelet transfusion.
Conclusions
This data suggests BAL to be safe even when platelet counts are <20x103/μL.
Current Evidence Regarding Adjuvant Treatment Option in Renal Cell Carcinoma
Authors: Fragkoulis Charalampos , Stamatakos Panagiotis Velissarios , Dellis Athanasios 
Published: January 2024

Abstract
Surgical treatment consists of the gold standard approach in patients diagnosed with nonmetastatic renal cell carcinoma (RCC). However, a great proportion of such patients will relapse postoperatively and metastatic disease will develop. In the present study, we present a review of the literature about available data regarding adjuvant treatment options in patients with RCC treated surgically.
Evaluation of Initial 24-core Transrectal Prostate Biopsy on the Detection of Significant Prostate Cancer and High-grade Prostatic Intraepithelial Neoplasia
Authors: Karyotis Ioannis , Dimitrios Danielyants , Ioannis Kravvaritis , Michael Nomikos , Vasileios Tzortzis , Dimitrios Delakas 
Published: January 2024

Abstract

Purpose:
The purpose of the study was to assess the diagnostic value of an initial 24-sample transrectal ultrasound-guided (TRUS) prostate biopsy protocol compared to the 10-core technique.

Materials and Methods:
We retrospectively reviewed the prostate biopsy database of consecutive men undergoing prostate biopsies under local anesthesia using the 10 (Group A) and 24 (Group B) protocols. Men were stratified according to biopsy protocol and prostate-specific antigen (PSA) levels. Exclusion criteria were age = 75 years and PSA >20 ng/mL. The Mann–Whitney U and Fisher’s exact test were used for statistical analysis.

Results:
Between November 2018 and August 2020, 169 men underwent TRUS prostate biopsies. Group A (10-cores) consisted of 105 (62.13%) men and Group B (24-cores) included 64 (37.86%) men. The overall prostate cancer detection rate was 41.05% and 36.72% in Groups A and B, respectively (P = 0.48). An overall 9.8% increase in Gleason 7 detection rate was found in Group B (P = 0.24). The high-grade prostatic intraepithelial neoplasia (HGPIN) detection rate in men with negative initial biopsies was 15.54% and 35.55% in Groups A and B, respectively (P < 0.001). In patients with PSA <10 ng/mL, the 24-core technique increased Gleason 7 detection rate by 13.4% (P = 0.16) and HGPIN by 23.4% (P = 0.0008), compared to the 10-core technique. The 24-core technique increased the concordance between needle biopsy and prostatectomy specimen compared to the 10-core technique (P < 0.002).

Conclusions:
The initial 24-core prostate biopsy protocol did not show any benefit in the detection of prostate cancer compared to the 10-core technique. However, it improved the HGPIN detection and the correlation between biopsy results and radical prostatectomy Gleason score in men with lower PSA levels.
Kinked Innominate Artery – A Rare Cause for Upper Limb Ischemia
Authors: Prathap K , Srinivasan Baskaran 
Published: January 2024

Abstract
Interventions of the aortic arch can lead to unexpected complication of atheroembolization from the plaques with many cases of CVA following TEVAR being reported in the literature. It is especially seen in old diabetic patients. Embolizations is a known entity in cases of loop Common carotid vessels. The abnormal curvature causes stasis of blood leading onto development of thrombus. Diseases related to Innominate artery are very rare. Kinking of Innominate artery is even rarer abnormality and very few cases only have been reported in the literature. The various clinical scenarios of kinked innominate artery reported are presence of pulsatile mass in the neck, In CXR the kinked artery masquerading as right upper lobe lung mass. Herein we report a case of Right upper limb little finger gangrene following coronary angiogram. On CT Angio evaluation it was found that there was thrombus in distal innominate and subclavian vessels with kinking of Innominate, Left Common carotid and Left Subclavian also. The passage of hardwares across the kinked innominate artery had caused the thrombus formation and subsequent embolization. This is the 1st case in literature to report the kinked innominate artery has caused a procedural complication. We report this case to inform that extreme caution should be undertaken during interventional procedures in cases of abnormal curvatures of great vessels to avoid complication.
Neurogenic Pulmonary Edema following Carotid Intervention: A Rare Case Report
Authors: Davulury Sri Satyavathi , Bhan Vinod , Vikrama K S Amitha 
Published: January 2024

Abstract
Extracranial carotid artery aneurysms are rare complication of atherosclerotic degeneration or traumatic neck injury and are managed with interventional and open surgical approaches with variable results. In cases with technical difficulties rarely managed with parent artery embolization. We present a case of a 50-year-old male with prior history of blunt neck injury during road traffic accident and presented with left-sided neck swelling 8 years after injury, diagnosed with internal carotid artery pseudoaneurysm, managed with parent artery embolization, 3 days later presented with hemiplegia and sudden respiratory distress, evaluated and diagnosed as massive cerebral infarct and acute pulmonary edema, managed with ventilator support and improved clinically within 48 hours, extubated. However patient developed sepsis during the hospital stay and succumbed to disease after 20 days. We present this case in view of rare presentation of neurogenic pulmonary edema following carotid intervention.
About an Observation of Glomuvenous Malformation of the Thumb
Authors: Souarji Ayyoub , Ar-Reyouchi Doha , Oufkir Ayat Allah 
Published: January 2024

Abstract
The glomuvenous malformation is a venous and cutaneous malformation that develops from a thermoregulatory unit called the glomus body. Our objective in this work is to clarify the latest terminologies of this pathology based on clinical, radiological, and histological criteria specific to this malformation; we report an exceptional case of a glomuvenous malformation in the thumb of a 41-year-old female patient, which undertook a surgical treatment with a simple postoperatory follow-up.
Rescue Bridging Thoracic Endovascular Aortic Repair in a Case of Type III Endo-leak with Impending Descending Thoracic Aortic Aneurysm Rupture
Authors: Jha Rakesh Kumar , Dutta Rohit , Kumar Sanjeev , Dwivedi Surjeet Kumar 
Published: January 2024

Abstract
A thoracic aortic aneurysm (TAA) is a localized dilatation of the thoracic aorta more than 1.5 times the normal diameter. In view of rupture risk, it requires either open or endovascular treatment. Open repair has higher complication rates, hence, thoracic endovascular aortic repair (TEVAR) is considered the treatment of choice for TAAs. TEVAR is a relatively safer procedure but not free from complications. Endoleak is a known complication of TEVAR and can be life-threatening. Type III endoleak is caused by a defect in the graft either due to fabric tear or disconnection of modular overlap. It accounts for 2.1% of all endoleaks and can lead to sac rupture and death. Hence, monitoring of patients by computed tomography angio or contrast-enhanced ultrasound is advocated to diagnose it early. We hereby report a case of Type III endoleak with impending aneurysm rupture, managed successfully by bridging TEVAR.
Gum Drop Technique with Pericardial Membrane for Treating Gingival Recession - A Case Report
Authors: Rao Abirami N. P. , Rajaram Vijayalakshmi , Mahendra Jaideep , Dave Pavithra H. , Ambalavanan N , Mahendra Little 
Published: January 2024

Abstract

Introduction:
Gingival recession was treated with gum drop technique (GDT) along with pericardial membrane, advanced platelet rich fibrin (A-PRF) and injectable platelet rich fibrin (i-PRF) in the defect sites for regeneration of soft tissue.

Patient Concerns:
Several 3-4 mm of recession sites in the maxillary right and left canine and premolar region. These sites were selected and divided into two groups: A and B based on the application with A-PRF and pericardium, respectively. Probing pocket depth (PPD), clinical attachment level (CAL), recession height (RH), recession width (RW) and keratinized tissue width (KTW) were assessed. The keratinized tissue width (KTW) was measured as the distance between the marginal gingiva and the mucogingival junction.

Treatment:
The defects were treated with the GDT following irrigation with i-PRF and followed up for 6 months. Both groups achieved significant root coverage which was stable even after 6 months post operatively. Keratinized tissue showed a 1 mm gain with pericardial membrane.
Facial Profile of Young Indian Women from Maharashtra-A Cross-Sectional Pilot Study
Authors: Baghele Om N. , Math Anusha A. 
Published: January 2024

Abstract

Context:
The anthropometric facial clinical proportions are used in the field of orthodontics, maxillofacial and plastic surgery for aesthetic or abnormality corrections. There is lack of enough literature on the facial profiles of Indians.

Aim:
To assess correlations between facial parameters and stature of young Maharashtrian women by using anthropometry.

Settings and Design:
It is a cross-sectional observational pilot study at Maharashtra Institute of Dental Sciences & Research, after approval from the Institutional Ethical Committee.

Methods and Material:
The study included 15 students of 21–23 years age selected by simple randomisation. The facial parameters were measured by sliding vernier calipers after identifying facial landmarks by stickers. Facial height (FH) in thirds; upper FH (UFH), middle FH (MFH) and lower FH (LFH); facial width (FW) and stature or overall height (OH) were calculated to define average facial features.

Statistical Analysis:
Multiple pairwise statistics and simple linear regression analyses were done for various dependent variables.

Results:
The means of UFH, MFH, LFH and total facial heights (TFH) were found to be 5.2 ± 0.54, 5.35 ± 0.34, 5.16 ± 0.44 and 15.7 ± 0.98 cm, respectively. The TFH showed a moderate correlation with stature (P ≤ 0.05, r = 0.64) and a strong correlation with lower lip length (P = 0.001, r = 0.78). Facial width showed a negative correlation with facial shape (P ≤ 0.05).

Conclusions:
The selected sample showed the statistically insignificant difference between UFH, MFH and LFH indicating equitable distribution among Indian women of Maharashtrian origin of 21–23 year age group. Longer TFH is positively correlated with higher stature and longer lower lip length.
Effect of 940 nm Diode Laser Irradiation and Dentin Bonding Agent on Permeability of Furcation Area in Primary Molars
Authors: Atif Mohammad , Tewari Nitesh , Mathur Vijay P. , Bansal Kalpana , Rahul Morankar 
Published: January 2024

Abstract

Purpose:
Multiple accessory canals make furcation area of primary molars the most common port of entry of bacterial endotoxins to periradicular area. Reduction in permeability can improve prognosis of these teeth. Therefore, this study was designed to compare the effect of 940 nm diode laser and dentin bonding agent on the dye penetration of furcation area in primary molars.

Material and Methods:
Thirty teeth were divided into three groups, that is, Group 1 (control group), Group 2 (dentin bonding agent applied over floor of pulp chamber), and Group 3 (diode laser irradiated over floor of pulp chamber). The samples were prepared and seven from each group were tested by dye penetration and three were sent for scanning electron microscopy. Rise in temperature in the perifurcal area was also recorded at the time of laser irradiation. Dunn’s pair-wise comparison analysis was used for the analysis for the difference in dye penetration among the group.

Results:
The maximum rise in temperature recorded postirradiation was 6.90C. Dye penetration was significantly reduced in Group 2 Dentin bonding group (DBG) as compared to control group (P = 0.0025). Reduction in permeability was observed in Group 3 Laser group (LG) but this was not statistically significant (P = 0.197). Scanning electron microscope revealed open dentinal tubules in Group 1. There were no open dentinal tubules in Group 2, while Group 3 had sealed dentinal tubules with glass-like surface over the region.

Conclusion:
Dentin bonding agent led to substantial decrease in dye penetration of furcation area of primary molars. This method should be evaluated clinically to improve successful pulpectomy procedures of primary molars.
A Study to Evaluate the Effectiveness of Various Disinfectants for Extracted Human Teeth - A Comparative Study
Authors: Srivastava Himanshu , Qureshi Sameera Mohd Rehman , Singh Chintu Kumar , Mastud Santoshkumar Pandurang , Handa Amit , Shukla Manish Kumar 
Published: January 2024

Abstract

Objectives:
The aim of this study was to evaluate the effectiveness of various disinfectants for extracting human teeth. The objectives were to assess the effectiveness of 5% vinegar, 3% hydrogen peroxide, 70% alcohol, and 5.25% sodium hypochlorite for disinfection of extracted human teeth.

Methods:
The teeth were divided into one of the following four groups consisting of 10 teeth in each group. All teeth were immersed in separate bottles containing 10 ml of the disinfectant for 7 days at 25°C. No visible growth in the broth was considered effective disinfection. The Institutional Ethics Committee (IEC) Number is SVIEC/ON/DENT/SRP/15186, and the IEC Clearance number is SVIEC/ON/DENT/SRP/15040.

Results:
Vinegar was most effective for bacterial disinfection, and 5.25% sodium hypochlorite was most effective for fungal disinfection. The result was statistically significant with Chi-square values of 0.015 and 0.057, respectively, and P < 0.001.

Conclusions:
Extracted teeth should be handled with extreme care as these are a potential source of infection. The present study documented the role of various disinfectants. Vinegar can be used as an effective disinfectant medium for extracting human teeth. Sterilisation and autoclaving are superior options while vinegar is cheap, readily available, and relatively non-toxic. All these qualities plus the fact that it has given encouraging results as an antibacterial disinfectant should necessitate its usage on a more regular basis than it is used at present.