bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short‐term and long‐term outcomes of submucosal dissection for residual or recurrent colorectal tumors after endoscopic resection: Analysis of a multicenter prospective study
Authors: Tanaka Hirohito , Uraoka Toshio , Kobayashi Nozomu , Ohata Ken , Takeuchi Yoji , Chino Akiko , Yamada Masayoshi , Tsuji Yosuke , Hotta Kinichi , Harada Keita , Ikematsu Hiroaki , Murakami Takashi , Tsuji Shigetsugu , Katagiri Atsushi , Hori Shinichiro , Michida Tomoki , Suzuki Takuto , Fukuzawa Masakatsu , Kiriyama Shinsuke , Fukase Kazutoshi , Murakami Yoshitaka , Ishikawa Hideki , Nagahara Akihito , Saito Yutaka 
Published: December 2023

ObjectivesWe previously demonstrated that a favorable long‐term prognosis indicated that endoscopic submucosal dissection (ESD) could be the standard treatment for large colorectal epithelial neoplasms, but the usefulness of ESD for local residual or recurrent tumors with submucosal fibrosis has not been fully demonstrated. The aim of the present study was to assess the usefulness of ESD for local residual or recurrent colorectal tumors.MethodsWe conducted a nationwide multicenter prospective study to evaluate the outcomes of ESD for colorectal tumors. In this post hoc analysis, a total of 54 local residual or recurrent colorectal tumors in 54 patients were included, and we analyzed the short‐term and long‐term outcomes of ESD for these lesions.ResultsThe median size of the lesions was 16.0 (interquartile range [IQR] 11–25) mm. ESD was completed in 53 cases (98.1%) with a median procedure time of 65.0 min, but it was discontinued in one case because of submucosal cancer invasion. En bloc resection was achieved in 52 cases (96.3%), whereas R0 resection was achieved in 45 cases (83.3%). Intraoperative perforation was observed in four cases (7.4%) and delayed perforation in one (1.9%), but all cases could be managed conservatively. Delayed bleeding was not observed. There were no significant differences in short‐term outcomes between the rectal and colonic lesions. There was no recurrence of the tumor during the median follow‐up period of 60 (IQR 50–64) months.ConclusionAn analysis of our multicenter prospective study suggests that ESD is an effective salvage management for local residual or recurrent colorectal lesions.
Advancements in metabolic‐associated steatotic liver disease research: Diagnostics, small molecule developments, and future directions
Authors: Eeda Venkateswararao , Patil Nikhil Yuvaraj , Joshi Aditya Dilip , Awasthi Vibhudutta 
Published: December 2023

AbstractMetabolic (dysfunction)‐associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, is a growing global health concern with no approved pharmacological treatments. At the same time, there are no standard methods to definitively screen for the presence of MASLD because of its progressive nature and symptomatic commonality with other disorders. Recent advances in molecular understanding of MASLD pathophysiology have intensified research on development of new drug molecules, repurposing of existing drugs approved for other indications, and an educated use of dietary supplements for its treatment and prophylaxis. This review focused on depicting the latest advancements in MASLD research related to small molecule development for prophylaxis or treatment and diagnosis, with emphasis on mechanistic basis at the molecular level.
Seroprevalence of SARS‐CoV‐2 infection in the general population of Nepal during the first and second generalized waves of the COVID‐19 pandemic—2020–2021
Authors: Paudel Krishna Prasad , Samuel Reuben , Jha Runa , Pandey Basu Dev , Edirisuriya Chathura , Shrestha Nebin Lal , Gyawali Pradip , Pokhrel Amrit , Shrestha Lilee , Mahato Ram Kumar , Hossain Shaikh Shah , Arunkumar Govindakarnavar , Bose Anindya Sekhar , Dhimal Meghnath , Gautam Dipendra , Neupane Subash , Thakur Nishant , Shrestha Saugat , Bhusal Nirajan , Jha Priya , Gupta Binod Prasad , Rayamajhi Rajan Bikram , Subedi Koshal Chandra , Kandel Shashi , Poudel Mukesh , Thapa Lila Bikram , Sharma Guna Nidhi , Gocotano Allison Eugenio , Sunny Avinash K. , Gautam Rabin , Bhatta Deepak Raj , Awale Bal Krishna , Roka Bhola , Ojha Hemant Chandra , Baral Phanindra , Adhikari Mahendra Dhose , Lohani Guna Raj , Shrestha Mahendra , Singh Dipendra Raman , Aryal Laxman , Pandav Rajesh Sambhajirao , Pokhrel Roshan 
Published: December 2023

AbstractFew seroprevalence studies have been conducted on coronavirus disease (COVID‐19) in Nepal. Here, we aimed to estimate seroprevalence and assess risk factors for infection in the general population of Nepal by conducting two rounds of sampling. The first round was in October 2020, at the peak of the first generalized wave of COVID‐19, and the second round in July–August 2021, following the peak of the wave caused by the delta variant of SARS‐CoV‐2. We used cross‐sectional probability‐to‐size (PPS)‐based multistage cluster sampling to estimate the seroprevalence in the general population of Nepal at the national and provincial levels. We tested for anti‐SARS‐CoV‐2 total antibody using the WANTAI SARS‐CoV‐2 Ab ELISA kit. In Round 1, the overall national seroprevalence was 14.4%, with provincial estimates ranging from 5.3% in Sudurpaschim to 27.3% in Madhesh Province. In Round 2, the estimated national seroprevalence was 70.7%, with the highest in the Madhesh Province (84.8%) and the lowest in the Gandaki Province (62.9%). Seroprevalence was comparable between males and females (Round 1, 15.8% vs. 12.2% and Round 2, 72.3% vs. 68.7%). The seroprevalence in the ecozones—Terai, hills, and mountains—was 76.3%, 65.3%, and 60.5% in Round 2 and 17.7%, 11.7%, and 4.6% in Round 1, respectively. In Nepal, COVID‐19 vaccination was introduced in January 2021. At the peak of the first generalized wave of COVID‐19, most of the population of Nepal remained unexposed to SARS‐CoV‐2. Towards the end of the second generalized wave in April 2021, two thirds of the population was exposed.
Effects of 1‐kestose on microbiome changes caused by vonoprazan: a randomized, double‐blind, placebo‐controlled pilot study
Authors: Furune Satoshi , Suzuki Takahiro , Honda Takashi , Yamamoto Kenta , Furukawa Kazuhiro , Nakamura Masanao , Ishigami Masatoshi , Kinoshita Fumie , Kadota Yoshihiro , Tochio Takumi , Shimomura Yoshiharu , Hirooka Yoshiki , Fujishiro Mitsuhiro , Kawashima Hiroki 
Published: December 2023

AbstractBackground and AimPotassium‐competitive acid blockers more strongly suppress the gastric acid barrier than proton pump inhibitors and cause dysbiosis. However, preventive measures in this regard have not been established. We aimed to evaluate whether 1‐kestose, a known prebiotic, was effective at alleviating dysbiosis caused by potassium‐competitive acid blockers.MethodsPatients scheduled to undergo endoscopic resection for superficial gastroduodenal tumors were enrolled and randomized 1:1 to receive either 1‐kestose or placebo. All patients were started on potassium‐competitive acid blocker (vonoprazan 20 mg/day) and took 1‐kestose 10 g/day or placebo (maltose) 5 g/day for 8 weeks. The primary outcome was the effect of 1‐kestose on potassium‐competitive acid blocker‐induced alterations in the microbiome. The fecal microbiome was analyzed before and after potassium‐competitive acid blocker treatment via MiSeq (16S rRNA gene V3–V4 region).ResultsForty patients were enrolled, and 16 in each group were analyzed. In the placebo group, the Simpson index, an alpha diversity, was significantly decreased and relative abundance of Streptococcus was significantly increased by 1.9‐fold. In the kestose group, the Simpson index did not change significantly and relative abundance of Streptococcus increased 1.3‐fold, but this was not a significant change. In both groups, no adverse events occurred, ulcers were well healed, and pretreatment and posttreatment short‐chain fatty acid levels did not differ.ConclusionsThe potassium‐competitive acid blocker caused dysbiosis in the placebo group; this effect was prevented by 1‐kestose. Thus, 1‐kestose may be useful in dysbiosis treatment.
Usual‐paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging
Authors: Garcia Reagan E. , Cawthon Peggy M. , Nicklas Barbara J. , Goodpaster Bret H. , Coen Paul M. , Forman Daniel E. , Cummings Steven R. , Newman Anne B. , Glynn Nancy W. 
Published: December 2023

AbstractBackgroundCardiopulmonary exercise testing (CPET), the gold‐standard method to quantify cardiorespiratory fitness (CRF), is not always feasible due to cost, access, and burden. The usual‐paced 400 m long distance corridor walk (LDCW), a measure of mobility among older adults, may provide an alternate method to assess CRF. The purpose of this study was to develop and validate an estimating equation to estimate VO2peak from average 400 m walking speed (WS) among participants in the Study of Muscle, Mobility and Aging (SOMMA).MethodsAt baseline, women (58%) and men age 70 years and older enrolled in SOMMA (N = 820, 76.2 ± 4.9 years, 86% Non‐Hispanic White) completed a 400 m LDCW (400 m WS = 400 m/completion time in seconds) and symptom‐limited maximal CPET (Modified Balke Protocol). VO2peak (mL/kg/min) was considered the highest 30‐second average oxygen consumption during CPET. Other covariates included: age, sex, race, physical activity (7‐day wrist‐worn accelerometer), physical function (Short Physical Performance Battery, range 0–12), perceived physical fatigability (Pittsburgh Fatigability Scale, range 0–50), and Borg Rating of Perceived Exertion (RPE, range 6–20) at completion of the 400 m LDCW. Stepwise linear regression was used. Internal validation was completed using data‐splitting method (70%; 30%).ResultsMean VO2peak was 20.2 ± 4.8 mL/kg/min and mean 400 m WS was 1.06 ± 0.2 m/s. Each 0.05 m/s increment in 400 m WS was associated with a 0.40 mL/kg/min higher VO2peak after covariate adjustment. An estimating equation including 400 m WS, age, sex, race, and RPE was developed. Internal validation showed low overall bias (−0.26) and strong correlation (r = 0.71) between predicted and measured VO2peak values. Bland–Altman plot and regression analyses indicated predicted VO2peak was an acceptable alternative, despite mean underestimation of 4.53 mL/kg/min among the highly fit.ConclusionsUsual‐paced 400 m LDCW strongly correlates with direct measures of CRF during CPET in older adults with lower fitness and can be used to test both fitness and function.
MMP‐2‐mediated Scube2 degradation promotes blood–brain barrier disruption by blocking the interaction between astrocytes and endothelial cells via inhibiting Sonic hedgehog pathway during early cerebral ischemia
Authors: Shi Tengrui , Yue Shiqin , Xie Cong , Li Xiaofeng , Yang Dexin , Hu Linghui , Zhong Yunxue , Zhang Yuan , Liu Wenlan 
Published: December 2023

AbstractWe have previously demonstrated a rapid secretion of matrix metalloproteinase‐2 (MMP‐2) in the ischemic brain. Since Scube2 can interact with Sonic hedgehog (Shh) to maintain blood–brain barrier (BBB) integrity via regulating the interaction between brain capillary endothelial cells (ECs) and perivascular astrocytes, and it is also a substrate of MMP‐2, we hypothesized that the secreted MMP‐2 could degrade Scube2 and contribute to ischemic BBB disruption. Using an in vitro ischemic model of 90‐min oxygen–glucose deprivation/3‐h reoxygenation (OGD/R) and an in vivo mouse stroke model of 90‐min middle cerebral artery occlusion (MCAO) with 3‐h reperfusion, we established an important role of MMP‐2‐mediated Scube2 degradation in early ischemic BBB disruption. Exposure of C8‐D1A cells and bEnd.3 cells to OGD/R increased MMP secretion in both cells, and C8‐D1A cells appeared to secrete more MMPs than bEnd.3 cells. Co‐IP and double‐immunostaining revealed that Scube2 co‐localized well with MMP‐2 in C8‐D1A cells and could be pulled down by MMP‐2 antibodies. In MCAO mice, Scube2 protein showed a drastic reduction in ischemic brain tissue, which was accompanied by suppressed expression of Shh and its downstream molecules. Of note, specific knockdown of astrocytic Scube2 with AAV‐shScube2 augmented MCAO‐induced Shh suppression and exacerbated BBB leakage and inflammatory reactions in the ischemic brain. Last, incubation of bEnd.3 cells with conditioned medium derived from OGD‐treated C8‐D1A cells led to a significant inhibition of the Shh pathway in bEnd.3 cells and degradation of VE‐cadherin and ZO‐1. Inhibition of MMP‐2 with SB‐3CT or over‐expression of Scube2 with plasmids in C8‐D1A cells alleviated the above effect of C8‐D1A cells‐derived conditioned medium. Taken together, our data indicate that ischemia‐induced secretion of MMP‐2 may contribute to early BBB disruption in ischemic stroke via interrupting the shared Scube2‐Shh pathway between brain capillary ECs and perivascular astrocytes.image
Review of behavioral economics models of the altruistic crowding‐out effect from monetary incentives
Authors: Bruers Stijn 
Published: December 2023

AbstractThe altruistic crowding‐out effect is a decrease of prosocial behavior due to monetary incentives or material rewards that intend to increase an extrinsic motivation for the behavior. The decrease in a behavior by increasing a motivation for that behavior, seems irrational, but behavioral economists presented a dozen different models to explain this crowding‐out effect. In these models, the decrease in prosocial behavior is rational in the sense that agents maximize their expected utility. All the models assume that people have utility functions that represent their preferences and motivations. This review clarifies different kinds of motivations, rewards, incentives, and crowding‐out effects, presents 13 behavioral economics models, classifies them in five types of models, discusses subtle nuances of the models, summarizes the different predictions of the different models, and provides an overview of the empirical support of the models. The main take‐away is that the crowding‐out effect could not only be explained in terms of rational, utility‐maximizing behavior, but could be done so in many (at least 13) different ways. This review can be used to improve empirical validation of the models and to gain insights in the specific contexts in which crowding‐out occurs.
Frontal and anterior temporal hypometabolism post chemoradiation in head and neck cancer: A real‐world PET study
Authors: Bishay Steven , Robb W. Hudson , Schwartz Trent M. , Smith David S. , Lee Lok Hin , Lynn Cynthia J. , Clark Tammy L. , Jefferson Angela L. , Warner Jeremy L. , Rosenthal Eben L. , Murphy Barbara A. , Hohman Timothy J. , Koran Mary Ellen I. 
Published: December 2023

AbstractBackground and PurposeAdverse neurological effects after cancer therapy are common, but biomarkers to diagnose, monitor, or risk stratify patients are still not validated or used clinically. An accessible imaging method, such as fluorodeoxyglucose positron emission tomography (FDG PET) of the brain, could meet this gap and serve as a biomarker for functional brain changes. We utilized FDG PET to evaluate which brain regions are most susceptible to altered glucose metabolism after chemoradiation in patients with head and neck cancer (HNCa).MethodsReal‐world FDG PET images were acquired as standard of care before and after chemoradiation for HNCa in 68 patients. Linear mixed‐effects voxelwise models assessed changes after chemoradiation in cerebral glucose metabolism quantified with standardized uptake value ratio (SUVR), covarying for follow‐up time and patient demographics.ResultsVoxelwise analysis revealed two large clusters of decreased glucose metabolism in the medial frontal and polar temporal cortices following chemoradiation, with decreases of approximately 5% SUVR after therapy.ConclusionsThese findings provide evidence that standard chemoradiation for HNCa can lead to decreased neuronal glucose metabolism, contributing to literature emphasizing the vulnerability of the frontal and anterior temporal lobes, especially in HNCa, where these areas may be particularly vulnerable to indirect radiation‐induced injury. FDG PET shows promise as a sensitive biomarker for assessing these changes.
The Lived Experiences of Students With Food Allergies During a Usual Weekday
Authors: Martinez Laurie A. , Opalinski Andra S. , Herbert Linda 
Published: December 2023

ABSTRACTBACKGROUNDExtant literature indicates students living with food allergies (FA) experience biopsychosocial challenges (eg, social isolation, anxiety). The purpose of this study was to explore the experiences of students living with FA during a usual weekday in a school setting.METHODSPhenomenological study with purposive convenience sample from the US states of Florida and Colorado. Students aged 10‐14 years who have been managing an IgE‐mediated FA for more than 1 year within a school setting. Data collection was guided by a story path process with semi‐structured interview, with Interpretive Phenomenological Analysis used to ascribe meaning to their experiences.RESULTSFour themes: (1) Living with Restraints: A Way of Life, (2) Managing Exposure, (3) Experiencing Stigma, and (4) Experiencing Lack of Knowledge.CONCLUSIONFindings underscore unique biopsychosocial challenges faced by students living with FA, highlighting the need for comprehensive approaches beyond traditional biological management in developing strategies, policies, future research, and recommendations in school settings.
Attention and purchase intention of sounding advertisements—A study on autonomous sensory meridian response of towel sound
Authors: Liang Chih‐Chin , Li Chao‐Hui 
Published: December 2023

AbstractIn the face of Taiwan's declining textile industry, companies strive to enhance product visibility but to little avail. Emphasizing personalized marketing in online advertising, they are exploring consumer‐preferred streaming adverts. However, the distracting nature of streaming media presents an obstacle. Herein, our research offers a solution. Utilizing audio autonomous sensory meridian response (ASMR), evidenced to significantly amplify skin conductance rate and brainwave activity, consumer attention can be effectively garnered. Studies have found that watching videos with the sound effect of ASMR can help the audience concentrate. Changes in brainwaves and skin conductance rates, when consumers use towel product, can be used to explore whether the participants are affected by ASMR. The results showed that audio ASMR streaming significantly increased the skin conductance rate and the brainwave of left anterior frontal area. This means that audio ASMR can attract consumer attention. The survey results have shown that all hypotheses were supported.Practical ApplicationsThis research explores the use of autonomous sensory meridian response (ASMR) in online advertising for the declining textile industry in Taiwan. ASMR, a unique sound that captures attention and induces relaxation, has been shown to increase consumer concentration and purchase intention. By integrating ASMR into towel advertisements and analyzing participants' physiological signals, such as skin conductance rate and brainwave activity, the study found that audio ASMR significantly attracted consumer attention and increased purchase intentions. The findings suggest that textile companies should incorporate ASMR into their marketing strategies to effectively engage consumers and boost sales. Moreover, understanding audience preferences for specific ASMR sounds is crucial for achieving the desired advertising effects.
Identification of Eimeria acervulina (Apicomplexa: Eimeriidae) infecting the broiler chicken Gallus gallus domesticus through morphology and molecular analyses
Authors: Mohammed Osama B. , Al‐Shaebi Esam M. , Al‐Quraishy Saleh , Omer Sawsan A. , Abdel‐Gaber Rewaida 
Published: December 2023

AbstractCoccidiosis is an intestinal protozoan disease that affects the poultry industry worldwide. The severity of this disease varies depending on the identity of the infectious agents. Therefore, this study was carried out to identify the Eimeria species that affect broiler chickens, Gallus gallus domesticus, through morphological and molecular phylogenetic analyses. Twenty‐five faecal samples were collected from the broiler chickens in a commercial poultry farm in Riyadh (Saudi Arabia). Using the floatation technique, faeces were examined microscopically for the Eimeria occurrence. Identification of Eimeria species was performed based on morphological criteria and molecular tools (DNA amplification for the partial small subunit ribosomal RNA (18S rRNA), internal transcribed spacer (ITS)‐1, and mitochondrial cytochrome c oxidase I (COI) genes. In this study, 32% (8 out of 25) of collected samples were found to be positive for coccidiosis. After sporulation in potassium dichromate (K2Cr2O7), the sporulated oocysts were observed as ovoid and measured 18.37–23.19 µm (19.87) long and 15.07–18.67 µm (16.46) wide, with the anterior location of a polar granule and absence of micropyle. These Eimeria oocysts were assumed to size and shape characteristics of Eimeria acervulina. Molecular analysis was conducted on the sequences of the polymerase chain reaction products from the three genes studied (18S rRNA, ITS‐1, and COI). At the three genes, results showed that the resultant sequences clustered with E. acervulina from different regions confirming morphological description. This study highlighted the importance of molecular techniques to detect avian Eimeria species more than the traditional morphology‐based tool to optimise the appropriate anticoccidial strategies for long‐term control in the studied area.
The minimally important difference for the Xerostomia Inventory among Sjögren's disease patients
Authors: Assy Zainab , Thomson William Murray , Brand Henk S. , Cha Seunghee , Susam Merve M. , Weisman Gary A. , Vissink Arjan , Bikker Floris J. , Jager Derk Hendrik Jan 
Published: December 2023

AbstractObjectiveUntil now, the clinically relevant improvement for the Xerostomia Inventory (XI) has not been defined. Therefore, our aim was to determine the Minimally Important Difference (MID) of the XI for improvement in dry‐mouth symptoms in SjD patients.MethodThe study recruited 34 SjD patients who underwent sialendoscopy of major salivary glands and 15 SjD patients in a nonintervention control group. XI scores were assessed at several time points. The MID was determined from the mean difference in XI scores between the groups with and without improvement.ResultsIn the control group, no significant XI score changes were seen. In the sialendoscopy group, a clinically relevant XI score change of four scale points was identified after 1 week. For a prolonged duration (≥16 weeks), a minimum reduction of seven scale points in the XI score was required to indicate clinically relevant improvement.ConclusionIn SjD patients, a minimum change of four points in the XI score indicates a clinically relevant improvement for evaluating short‐term effects. For prolonged effects, a clinically relevant improvement requires a MID of seven points. The determination of the MID in XI could assist in future studies that evaluate changes in xerostomia.