bluuebunny/crossref_metadata_2025_split huggingface dataset:
Swear Words From the Indramayu Javanese-Indonesia in the Novel Aib dan Nasib
Authors: Juidah Imas , Andayani  , Suwandi Sarwiji , Rohmadi Muhammad 
Published: February 2024

Swear words are impolite words or words that make other people offended or get angry. Every region has its’ own particular swear words, especially in Indramayu. The swear words used by the Javanese people of Indramayu have various types and functions. Therefore, this study describes the types and functions of Indramayu Javanese swear words in the novel Aib dan Nasib by Minanto. The result reported nine types of swear words in the novel Aib and Nasib by Minanto. They are 1) excretion in the word of tahi; 2) death in the word of mampus; 3) body function term in the word of kontol, memek, endas, kuping; 4) religious term in the word of dedemit, setan; 5) mother in law in the word of telembuk, lonte, perung, jalang; 6) sex term in the word of ngentot, rabenan; 7) animal term in the word of kirik, ketek; 8) imbecilic term in the word of dungu, goblok, koplok, cecunguk, campleng; 9) general term in the word of, sinting, lancang, bangsat. Meanwhile, the functions of those swear words in the novel Aib dan Nasib by Minanto are: to create attention; to discredit; to provoke; to create interpersonal identification; and to provide catharsis.
Shear-Wave Velocity Model for the Dead Sea Transform from Multimode Inversion of Surface Waves Excited by the February 2023 Southeast Türkiye Earthquake Sequence
Authors: Lellouch Ariel , Inbal Asaf , Ziv Alon 
Published: February 2024

Abstract
The dispersive nature of surface waves can be used for shear-wave velocity inversion at different scales. We show that four large earthquakes from the 2023 Türkiye earthquake sequence generate visible surface waves recorded by a dense strong-motion network deployed along the Dead Sea Transform (DST) in Israel. Thanks to favorable geometrical conditions and source radiation patterns, we observe both Rayleigh and Love waves that travel predominantly parallel to the network. We can reliably compute the dispersion of three Love-wave modes and two Rayleigh-wave modes. Using these dispersion curves, we invert for a 1D S-wave velocity model of the entire DST, outperforming an existing model. Statistical and kernel sensitivity analysis show high certainty down to a depth of 30 km thanks to the multimode joint inversion in the frequency band of 0.03–0.3 Hz. Using a multiwindow approach, we invert for an along-strike laterally varying velocity model of the DST. Although it is limited to the fundamental Love-wave mode, using the 1D model as a constraint allows us to recover a shallow (10 km) velocity structure in agreement with previous studies of the area. Despite the simplicity of our used approach, it can be used as a basis for more advanced studies.
Rendimiento y composición química de Panicum maximum cv. Tanzania en un sistema silvopastoril en Chiapas
Authors: Pérez-Luna Esaú , Ruiz-Sesma Benigno , Sánchez-Roque Yazmin , Canseco-Pérez Miguel Angel , Pérez Luna Yolanda del Carmen 
Published: February 2024

Para evaluar el efecto de la incorporación de L. leucocephala sobre la producción de biomasa y la composición química de P. maximum cv. Tanzania en un sistema silvopastoril, se estableció un experimento en dos praderas, establecidas con P. maximum cv. Tanzania como único cultivo en una de ellas y en la otra asociada con L. leucocephala en un arreglo de pasturas en callejones. En cada pradera fueron colocadas 12 jaulas de exclusión de 1m3 en un diseño completamente al azar con arreglo factorial 2x4, dos sistemas (monocultivo y silvopastoril) y cuatro fechas de corte (28, 56, 84 y 112 días) y tres repeticiones. Se aplicó una fertilización química con Fosfonitrato en cada una de las jaulas de exclusión para ambos tratamientos. Se observó diferencia significativa entre sistemas para las variables altura, cobertura, producción de materia orgánica (kg/ha), producción de proteína cruda (kg/ha) y el porcentaje de FDN, reportando los mejores valores el sistema silvopastoril. Se concluye que el uso de la Leucaena ofrece ventajas importantes si se considera que es capaz de producir alimento de alto valor nutricional para los animales, además, mejora la calidad y cantidad de forraje del sistema.
Strategies to Mitigate Bleeding in Shoulder Arthroplasty in the Setting of an Arteriovenous Fistula
Authors: Seidl Adam J. , Ahmed Abdulaziz F. , Woods David , Abboud Joseph A. , Bravman Jonathan T. 
Published: February 2024

Case:
Arteriovenous (AV) fistula in the ipsilateral extremity for hemodialysis presents unique challenges during shoulder arthroplasty. We describe 3 cases of shoulder arthroplasty performed through a deltopectoral approach on the ipsilateral side of an AV fistula. In all cases, the cephalic vein was found to be arterialized with increased diameter and thickness. All procedures were successfully performed without injury to the arterialized cephalic vein.

Conclusion:
This report highlighted strategies to mitigate catastrophic bleeding from an arterialized cephalic vein during shoulder arthroplasty, which includes preoperative cross-matching, expeditious vascular surgery availability, meticulous surgical dissection, and careful retractor placement.
Ovarian Yolk Sac Tumor in a 13-year-old Girl with McCune-Albright Syndrome
Authors: Yang Jie , Zhang Xinyue , Yang Jiaxin , Li Lei 
Published: February 2024

Abstract

Background
MacCune-Albright Syndrome (MAS) is typically characterized by the triad of café-au-lait spots, fibrous dysplasia, and peripheral precocious puberty, along with variety of phenotypes including cancers.
Patient and Methods:
We report a 13-year-old girl who was found to have both MAS triad and an ovarian yolk sac tumor. Clinical features and follow-up information was documented. Peripheral blood, tumor tissue and biopsy from the benign ovarian were collected for the molecular analysis, DNA samples were extracted from the three kinds of samples. RNA molecules were extracted from tumor biopsy specimen to analyze the expression profile including metabolic and immune characteristics through nanostring.
Results
Beside the classic triad of MAS, the patient presented with other unique clinical conditions including ovarian yolk sac tumor and autoimmune related thrombocytopenia. Whole exosome sequencing revealed germline pathogenic missense mutation of TP53 and PRSS1. GNAS variations noticed on 5’UTR were likely benign variant. Gene expression profiling suggested the upregulated KRAS and NRAS and down-regulated PTEN in yolk-sac tumor cells as compared to normal tissue. Metabolic analysis of tumor showed weak activity of vitamins metabolism and significantly elevated activity of the tricarboxylic acid cycle.
Conclusions
This is the first report wherein a patient with MAS was found to have a yolk sac tumor with sequencing demonstrating the germline TP53 mutation. The unusual genetic and expression findings raise the questions in understanding MAS and appropriate longtime surveillance for these patients.
On the origin of low-valent uranium oxidation state
Authors: Kvashnina Kristina , Silva Clara , Amidani Lucia , Retegan Marius , Bazarkina Elena , Weiss Stephan , Graubner Tim , Kraus Florian 
Published: February 2024

Abstract

Recently, numerous novel actinide compounds with exotic oxidation states have been reported, highlighting the significant role of 5f electrons in actinide bonding and the formation of new actinide systems. However, efforts to understand 5f electron systems are still hindered by the lack of high-quality experimental data, particularly for low-valent actinide compounds. In this study, we present the first measurements of X-ray absorption near-edge structure (XANES) in the high-energy resolution fluorescence detection (HERFD) mode at the uranium (U) M4 edge for the UIII and UIV halides, namely UX3 and UX4 (X = F, Cl, Br, I). The spectral shapes of these two halide families exhibit clear differences, which can be comprehended within the framework of crystal field multiplet theory. Electronic structure calculations were conducted for the 3d-4f Resonant Inelastic X-ray Scattering (RIXS) process, considering various strengths of electron-electron interactions between 3d, 4f, and 5f states. Our results confirm the capability of the HERFD XANES method at the M4 edges to detect the presence of low-valent compounds. Moreover, contrary to earlier expectations of increased ionicity in low-valent uranium compounds, our study reveals that the electronic structure of low-valent U systems exhibits heightened sensitivity to the influence of ligands surrounding the U atoms.
Occurrence of pharmaceutical residues in drinking water: a systematic review
Authors: Zanni Stefano , Cammalleri Vincenzo , D'Agostino Ludovica , Protano Carmela , Vitali Matteo 
Published: February 2024

Abstract

In the last decades, the use of drugs, both in clinical practice and in intensive livestock farms, has increased exponentially. Following urinary and/or faecal excretion, these compounds are only partially retained in the depuration facilities, reaching fresh or marine surface waters even distant from the source of entrance. The main consequence of this phenomenon is the presence, increasingly frequently found, of traces of drugs and their metabolites in the aquatic environment including drinking water. The aim of this review is to evaluate the contamination of drinking water by pharmaceutical residues all over the world. For this purpose, a systematic review was carried out for identifying all available research reporting original data resulting by sampling campaign and analysis of “real” drinking water samples to detect pharmaceutical residues. The investigated databases were PUBMED, SCOPUS and WEB OF SCIENCE. A total of 124 studies were included in the review and 33 of them found target analytes below the limit of detection, while the remaining 91 studies reported positivity for one or more compounds, in concentrations ranging from a few to a few tens of nanograms. This finding confirms the concern about drinking water contamination on a global scale and requires close attention from health authorities, pharmaceutical industries, and scientific community. Preventive interventions for drinking water contamination should be also targeted on technological improvement of wastewater purification plants and drinking water treatment plants to raise pharmaceutical residues removal.
GalNac-modified red blood cell-derived extracellular vesicles protect against liver diseases
Authors: Zhang Gengsheng , Huang Xiaofang , Yang Jie , Zhang Jianning , Ma Yang , Hu Yuanyuan , Lu Siyu , Li Shuai , Song Zheng , Li Chen , Qin Wei-dong 
Published: February 2024

Abstract
Liver diseases, including acute liver failure (ALF), non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC), are associated with high morbidity and mortality. However, the therapeutic options for liver diseases are currently limited. In this study, we have shown for the first time that red blood cell-derived extracellular vesicles (RBC-EVs) modified with triantennary N-acetyl galactosamine-(GalNac) sequences (GalNac-RBC-EVs) can selectively target hepatocytes as opposed to Kupffer cells via the asialoglycoprotein receptors (ASGPR) expressed on the former. Furthermore, RBC-EVs loaded with GalNac-miR-155-ASO (RBC-EVs/GalNac-miR-155-ASO) significantly reduced the mortality of mice with ALF, and alleviated pyroptosis, apoptosis and necroptosis (PANoptosis) of the hepatocytes. Likewise, PJ34-loaded GalNac-RBC-EVs (GalNac-RBC-EVs/PJ34) significantly improved the symptoms of NAFLD and stalled HCC progression in mouse models by inhibiting PARP-1. Furthermore, incorporation of Rab7-siRNA reduced PJ34 degradation in hepatocytes, thereby enhancing the therapeutic efficacy of GalNac-RBC-EVs/PJ34. Finally, the GalNac-RBC-EVs were well-tolerated and did not induce any systemic toxicity, or damage to vital organs. In conclusion, GalNac-modified RBC-EVs are a promising drug carrier for the precise treatment of various liver diseases based on their ability to specifically target hepatocytes.
Steady-State Data-Driven Dynamic Stability Assessment in the Energy Management System
Authors: Song Sungyoon , Min Sang-won , Jung Seungmin 
Published: February 2024

Abstract
The extensive research on dynamic security assessment stability prediction has focused on data preprocessing techniques to improve accuracy because it was assumed that high-resolution postfault data exist. For practical users, the acquisition and application of high-resolution measurement data present significant challenges. Installing phasor measurement units on all power system nodes is deemed impractical due to high costs. In this work, we aimed to develop a rotor angle stability prediction model using steady-state data that can be easily generated from current energy management system. Note that the steady-state measurement data refer to a pre-contingency operation condition characterized by real and reactive loads, generation levels, flows, as well as voltages and angles. The proposed framework comprises three stages: it finds physical meaning from the extended equal-area criterion to move away from the black-box approach, proposes a feature data extraction strategy to reduce the dimensionality of the input space in the support vector machine, and partition time-series power flow data by month to consider system topology changes. By utilizing 5-min-interval power flow data, unstable cases are determined, and two main feature data are extracted to train the support vector machine. The proposed model can be implemented in the energy management system for industrial use, and the obtained results showed the effectiveness of the proposed framework in responding to a critical line fault event in real time
Machine learning-enabled early detection of hepatocellular carcinoma utilizing cell-free DNA mutation and fragmentation multiplicity: a prospective study
Authors: Weiping Zhou , Zhou Ledu , Yuan Jie , Wu Weiqing , Ma Mengya , Liu Fang , Wei Zhouwei , Zhang Qun , Li Yongli , Lu Wen , Liang Lihua , Zhu Liwei , Gu Yunfan , Xu Jinjiang , Chen Siming , Su Chengming , Yuan Sheng-xian , Quan Xiangming , Fang Huan , Zhang Chao , Ji Liyan , Sun Jialun , Si Shubin , Su Bo , Xia Xuefeng , Yi Xin , Li Yong , Zeng Qiang 
Published: February 2024

Abstract

Successful development of effective hepatocellular carcinoma (HCC) early diagnosis methods could greatly benefit disease control. Relating to the early detection of liver cancer, multifarious methods exploiting the various genetic aberrations embedded in cell-free DNA have been proposed. Multifaceted feature integration could improve model performance and interpretability. The cohort design and prospective performance validation also significantly affect the model generality. Considering the current demerits, we conducted the PRospective Early Detection In a population at high-risk for Common malignant Tumor (PREDICT) study (clinical trial number NCT04405557), which integrated mainly single nucleotide variants (SNVs) and fragmentation information in model construction on 371 retrospective participants for efficient HCC early detection. The PREDICT model reached 88.41% sensitivity and 95.65% specificity and demonstrated outstanding performance among different clinicopathological populations. Additionally, we integrated the PREDICT model into physical examination packages and prospectively recruited 720 participants from 24 medical institutions. PREDICT model reached 100% sensitivity and 86.7% specificity. Our model reaches a relative equilibrium between cost, performance as well as interpretability and offers an alternative solution for HCC risky individual regular screening and healthy population preventive screening.
Establishment of a non-human primate model for acute spinal cord injury
Authors: Li Zhe , Song Xinghua , Song Jialai , Yao Huacan , Wu Chunhui , Cai Yuebo 
Published: February 2024

Abstract

Objective
To review and learn the knowledge of acute spinal cord injury(SCI), and analyze the feasibility and advantages of establishing of a non-human primate model for acute spinal cord injury with cynomolgus macaques.
Method
We selected female cynomolgus macaques to establish a acute spinal cord injury model at a specific segment of the spine with spinal cord hemisection. Before and after modeling, the muscle strength score, quantitative motor activity, as well as blood biochemical and blood routine indicators of the model monkey was observed and recorded to evaluate and analyze the effectiveness of the non-human primate model for acute spinal cord injury.
Result
In this experiment, a acute spinal cord injury model of crab eating monkeys was established by hemisection of the thoracic 9-segment (T9) spinal cord. The group (n = 2) was aged 13–14 years old, weighing 3.2-4.2kg, all females. By observing and recording the muscle strength score and quantitative motor activity of the model monkeys, it was evaluated that establishing a acute spinal cord injury model through crab eating monkeys is effective and feasible.
Conclusion
Non-human primates are recognized as an effective animal model for acute spinal cord injury repair research, but there are still some unresolved challenges in terms of repeatability, reducing other complications, and experimental costs.
Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
Authors: Murai Junko , Onji Hiroshi , Tate Sota , Sakaue Tomohisa , Fujiwara Kohei , Kawaida Miho , Onishi Nobuyuki , Matsumoto Takashi , Yamagami Wataru , Sugiyama Takashi , Higashimaya Shigeki , Pommier Yves , Kobayashi Yusuke 
Published: February 2024

Abstract

The preferential response to PARP inhibitor (PARPi) olaparib in BRCA-deficient and Schlafen 11 (SLFN11)-expressing ovarian cancers has been documented, yet the underlying molecular mechanisms remain unclear. As the accumulation of single-strand DNA (ssDNA) gaps behind replication forks is key for the lethality induced by PARPis, we investigated the combined effects of SLFN11 expression and BRCA deficiency on PARPis sensitivity and ssDNA gap formation in human cancer cells. PARPis increased chromatin-bound RPA2 and ssDNA gaps in SLFN11-expressing cells and even more in cells with BRCA1 or BRCA2 deficiency. SLFN11 was co-localized with chromatin-bound RPA2 under PARPis treatment, with enhanced recruitment in BRCA2-deficient cells. Notably, the chromatin-bound SLFN11 under PARPis did not block replication, contrary to its function under replication stress. SLFN11 recruitment was attenuated by the MRE11 inhibitor, mirin. Hence, under PARPis treatment, MRE11 expression and BRCA deficiency lead to ssDNA gaps behind replication forks, where SLFN11 binds and increases their formation. Ovarian cancer patients who super-responded (progression-free survival > 2 years) to olaparib maintenance therapy had a significantly higher SLFN11-positivity than short-responders (< 6 months). Our findings provide a mechanistic understanding of the favorable responses to PARPis in SLFN11-expressing and BRCA-deficient tumors and highlight the clinical implications of SLFN11.
Ecological Cooperative Adaptive Cruise Control of Electric Vehicles Heterogeneous Platoon with two Merging Events
Authors: Luo Tian , Liu Xiaobin , Zhou Benchun 
Published: February 2024

Abstract
Vehicle platooning improves energy savings based on vehicle-to-vehicle (V2V) communication. The ecological cooperative adaptive cruise control (Eco-CACC) is implemented in platoons for merging task by using event-triggered and regrouped platoon model. The merging positions are selected in the middle and the tail of an original platoon with a two-vehicle sub-platoon. The distributed nonlinear model predictive controller (DNMPC) approach is developed to model Eco-CACC merging strategy. Performances of Eco-CACC merging strategy is modeled by leaders and predecessor-followers objectives control method for predecessor-leader following (PLF) topology. The results demonstrate that merging position located in the tail exhibits superior performances, which can be used to improve the string stability, tracking performance and communication stability.
Rutin Treats Perimenopausal Depression Rats through Allopregnanolone Mediated mRNA Expression of Gabra4, Gabrb2 in the Prefrontal Cortex
Authors: Gao Zhan , Gao Mingzhou , Yu Xufeng , Song Tingting , Geng Li , Zhao Jing , Gao Dongmei , Sun Ya , Qiao Mingqi , Gao Jie , Wang Jieqiong 
Published: February 2024

Abstract

Objective
We determined whether the pathogenesis of perimenopausal depression (PMD) is associated with allopregnanolone (3α,5α-THP, ALLO) mediated GABAA receptors subunits expression changes in different brain regions. Simultaneously, we aimed to investigate the therapeutic efficacy and intervention mechanisms of the flavonoid rutin in treating PMD.
Methods
The PMD rat model was established by ovariectomy surgery followed by chronic unpredictable mirutin stress processes. ALLO was administered via intraperitoneal injection to increase ALLO levels in PMD rats, while rutin was administered via oral gavage for PMD treatment. Behavioral assessments, including open-fierutin test, sucrose preference test, and forced swimming test, were conducted to evaluate depressive-like behaviors in rats. ELISA was employed to measure the levels of E2, 5-HT, NE, ALLO, and GABA in the serum. Quantitative PCR was used to assess the mRNA expression of Gabra4, Gabrb2, and Gabrd in the prefrontal cortex, hippocampus, hypothalamus, and amygdala.
Results
The PMD rats exhibited depressive-like behavior, with decreased levels of E2, 5-HT, NE, ALLO, and GABA in the serum. The mRNA expression of Gabra4 and Gabrb2 increased in the prefrontal cortex, hippocampus, and hypothalamus of PMD rats, while Gabrd showed a increase in the hypothalamus and amygdala. ALLO improved depressive-like behavior and increased serum levels of E2, 5-HT, NE, and ALLO in PMD rats. ALLO acted on PMD rats, reduced mRNA expression of Gabra4 and Gabrb2 in the prefrontal cortex, increased mRNA expression of Gabrd in the prefrontal cortex, elevated mRNA expression of Gabra4 and Gabrd in the hippocampus, and decreased Gabrb2 mRNA expression in the hypothalamus.Rutin improved depressive-like behavior in PMD rats, increased serum levels of 5-HT and ALLO, and decreased mRNA expression of Gabra4 and Gabrb2 in the prefrontal cortex.
Conclusion
ALLO-mediated mRNA expression of Gabra4, Gabrb2 in the prefrontal cortex, and Gabrb2 in the hypothalamus is one of the pathological mechanisms in PMD. ALLO can improve depressive symptoms in PMD rats. Rutin (8.65 mg/kg) exerts a therapeutic effect on PMD by upregulating serum ALLO levels, subsequently downregulating mRNA expression of prefrontal cortex Gabra4 and Gabrb2.