bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quetiapine and Valproic Acid-induced Central Hypothyroidism in a
Patient with Autism Spectrum Disorder and Intractable Epilepsy: A Case
Report
Authors: Daramjav Narantsatsral , Takagi Junko , Iwayama Hideyuki , Kanemoto Kousuke , Otake Kazuo 
Published: January 2024

Objectives:
Patients with an autism spectrum disorder (ASD) are prone to disruptive
behaviors and aggression. A typical antipsychotics are used to treat these difficult ASD conditions.
Several psychotropic drugs have been linked to hypothyroidism. The clinical manifestation
of hypothyroidism is indistinguishable from that of an antipsychotic’s general adverse effect,
which can lead to a delayed or missed diagnosis. Conversely, thyroid dysfunction can exhibit
an impact on mood, anxiety, depression, and cognitive functions.

Case Study:
We present a case of central hypothyroidism caused by long-term use of
valproic acid (VPA) and adding quetiapine to risperidone. The current case had a history of hyperprolactinemia
and subclinical hypothyroidism caused by risperidone and VPA, respectively,
before the administration of quetiapine.

Conclusion:
This is the first report of quetiapine-induced central hypothyroidism in a patient
with ASD, as determined by a thyrotropin-releasing hormone (TRH) loading test. TRH loading
test may be useful in elucidating the pathogenesis of hypothyroidism in patients receiving quetiapine
and VPA. Thyroid function monitoring in patients taking quetiapine and VPA may provide
an opportunity to begin replacement therapy.
Design Formulation of Nanospanlastic Novel Carriers as a Promising
Approach to Enhanced Bioavailability in Intranasal Drug Delivery for
Sinusitis: Statistical Optimization and In vitro and In vivo Characterization
Authors: Chettupalli Ananda Kumar , Ajmera Srivani , Kuchukuntla Mounika , Palanivel Venkatesan , Katta Sunand 
Published: January 2024

Background:
Most new biologically active chemicals require better water solubility and slower dissolution rates. Cefdinir (CFD) has a very low bioavailability in its crystalline form and is poorly soluble in water.

Objective:
By preparing cefdinir's spanlastic nanovesicles (SNVs) using the ethanol injection method, the current study has attempted to enhance the drug's solubility and bioavailability using a statistical design approach.

Methods:
Independent variables, including the nonionic surfactant concentration, edge activator (EA), sonication time, SNVs entrapment efficiency, particle size, zeta potential, PDI, and in vitro release, have been evaluated. The best CFD-SNVs were positioned within in situ gel with muco-adhesive properties made of hydroxypropyl methylcellulose and deacetylated gellan gum. By contrasting intranasal injection of the produced gel with an IV solution, animal models have been used to investigate CFD's systemic and cerebral dynamics.

Results:
Statistical analysis has suggested an ideal SNVs formulation with nonionic surfactant (65 mg), EA (15 mg), and sonication (3 min). The sol-gel temperature for forming the mucoad-hesive in situ gel containing SNVs has been found to be 34.03°C, and 18.36 minutes has been the extended mucociliary transit time. Following intranasal injection, compared to SNV dispersion, the gelling system has exhibited higher brain bioavailability (2251.9 ± 75 vs. 5281.6 ± 51%, re-spectively). The gel has also demonstrated effective drug targeting of the brain with higher direct transport percentage indices.

Conclusion:
Mucoadhesive in situ gel with CFD-loaded SNVs can be administered via the in-tranasal route. To enhance bioavailability in the brain and drug targeting from the nose to the brain, nasal in situ gel loaded with CFD-SNVs could be a new carrier to be employed in sinusitis.
Nanomedicine as a Better Therapeutic Approach: An Overview
Authors: Das Arnab , Chakrabarti Srijita 
Published: January 2024

:
The fields of nanotechnology and nanomedicine have undergone a revolution. There has been a striking rise in authorized nanomedicines since 1980. Apart from functioning as thera-peutic agents, they also act as carriers for delivering various active pharmaceuticals to target or-gans. The ultimate goal of nanomedicine has always been the generation of translational technol-ogies that can improve current therapies. Nanocrystals, nanotubes, liposomes, exosomes, solid li-pid nanoparticles, polymeric nanoparticles, and metallic and magnetic nanoparticles are examples of nanostructures that are now in the market as well as in ongoing research. The preparation of these nanomaterials requires consideration of a number of difficulties. Only a few of these nano-materials were successful in obtaining marketing permission after passing all required toxicologi-cal and ethical evaluations and making them affordable to users and, at the same time, profitable to investors. Cancer, central nervous system (CNS) diseases, and cardiovascular (CVS) diseases represented the primary targets of nanotechnology applied to medicine. Therefore, this review ar-ticle is focused on providing a summary of several nano-based delivery systems, including their limitations and prospects in different therapeutic fields.
Media pembelajaran modul desain komunikasi visual dengan materi art merchandise untuk siswa SMK
Authors: Rohman Dwi Nur , Handoko Aran 
Published: January 2024

Penelitian bertujuan terciptanya modul Art Mercahadnise mata pelajaran komputer grafis dan mengetahui kelayakan modul dengan materi Art Merchandise untuk siswa sebagai materi pendamping belajar mandiri dan pembelajaran.Menggunakan metode ADDIE merupakan pembelajaran disengaja yang berpusat pada siswa, inovatif, otentik, dan inspiratif tersusun pada kerangka pengembangan dengan tahapan : menganalisis, mendesain, mengembangkan, mengimplementasikan, dan mengevaluasi (Branch, 2009:1). Tahapan penelitian observasi, wawancara, penemuan potensi dan masalah, pengumpulan data, mendesain produk, memvalidasi produk dengan memvalidasi instrumen, selanjutnya proses validasi oleh ahli materi, bahasa, media, dan guru komputer grafis, revisi desain sesuai dengan masukan dan kritik, pre-test , uji coba pada siswa kelas XI DKV, post-test, evaluasi bersama dengan pemberian angket penilaian modul belajar kepada siswa. Analisis data menggunakan kuantitatif dan kualitatif.Hasil penelitian modul belajar “Perancangan Art Merchandise” dapat dipergunakan siswa jenjang SMK kelas XI desain komunikasi visual materi pelajaran komputer grafis dalam bentuk buku modul pendamping serta file PDF. Hasil penilaian ahli materi, bahasa, media dan hasil dari guru komputer grafis memperoleh kategori baik, jika semua nilai dari setiap validator ahli dikonversikan dengan kriteria kualitatif memperoleh kategori nilai baik. Rata-rata pre-test dan post-test memiliki peningkatan rata-rata nilai sebesar 15,2 dari sebelum pengaplikasian modul yang diikuti oleh ketiga kelas dengan 77 siswa yang mengikuti test. Evaluasi modul melibatkan 87 siswa untuk menilai kelayakan modul didapatkan hasil rata-rata 88,4. Sehingga menghasilkan modul belajar bagi peserta didik yang layak dan dapat dipergunakan sebagai pendamping proses belajar mandiri dan pembelajaran siswa di sekolah.
Karakteristik bentuk dan warna seni mural karya komunitas Kawa Kutak Katik di kota Pangkalpinang
Authors: Hikam Ahdan Sayid , Suardana I Wayan 
Published: January 2024

Tujuan penelitian ini adalah untuk mendeskripsikan dan menganalisis bentuk dan karakteristik warna pada seni mural karya komunitas Kawa Kutak Katik yang ada di Kota Pangkalpinang, Provinsi Kepulauan Bangka Belitung. Metode penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif yaitu teknik pengumpulan datanya dengan membuat gambaran secara sistematis dan akurat mengenai fakta-fakta serta pada dasarnya mengenai bentuk dan karakteristik warna karya seni mural tersebut. Langkah-langkah penelitian meliputi pengumpulan data melalui observasi, wawancara, dan dokumentasi dengan alat bantu berupa: kamera, alat perekam (handphone). Sedangkan pemeriksaan keabsahan data dilakukan dengan perpanjangan keikutsertaan, ketekunan pengamat, dan triangulasi data. Hasil penelitian ini menunjukan bahwa: 1) Bentuk yang ditampilkan komunitas Kawa Kutak Katik pada karya mural yang ada di Kota Pangkalpinang berupa objek ikonik yang ada di Pulau Bangka. 2) Karakteristik warna seni mural karya komunitas Kawa Kutak Katik yang ada di Kota Pangkalpinang yang membawa pembaruan atau penyegaran sehingga memberikan warna baru yang mana sebelumnya karya mural yang sering ditemui masih bergaya tradisional atau harus mirip dengan objek aslinya, baik secara bentuk dan warna. Kata Kunci: Bentuk, Karakteristik, Warna, Seni Mural, Komunitas Kawa Kutak Katik
الطلبات المستعجلة وأثرها على مبدأ الأثر غير الواقف للطعن بدعوى الإلغاء
Authors: Hama Zana Rauf , Muhammed Rawsht Muhammed Ameen 
Published: January 2024

تتناول هذه الدراسة موضوع الطلبات المستعجلة أمام قضاء الإلغاء لوقف تنفيذ القرارات الإدارية و تأثيرها مبدأ على الأثر غير الواقف للطعن بدعوى الإلغاء ، إذ أنه من المؤكد لا يترتب على مجرد رفع الطلب المستعجل الى القضاء وقف تنفيذ القرار المطلوب الغاؤه، الإ انه يجوز للمحكمة في حالات محددة ان تامر بوقف تنفيذه اذا طلب المدعي ذلك في دعواه ورات المحكمة ان نتائج تنفيذ القرار المطعون فيه قد يتعذر تداركها. و يبدو من واقع الحال أن الحكمة من هذا الاستثناء، هي أنه قد يترتب على تنفيذ القرار المطعون فيه اضرار جسيمة يتعذر تداركها قبل الفصل في الدعوى، وقد لا يجدي فيها تعويض المتضرر من قبل الإدارة في حالة ثبوت ان قرارها كان خاطئا، وبذلك يصبح السير في دعوى الإلغاء غير ذي نفع ومجرد امر معنوي حتى لو تم إلغاء القرار، فاذا نفذ القرار الإداري المطعون فيه بالإلغاء ، يكون قد استنفذ اغراضه. علماً انه ليس لوقف تنفيذ القرار المطعون فيه بالالغاء اثرا تلقائيا لرفع دعوى الإلغاء، بل لابد من تحقق ضوابط وشروط معينه، وهذا ما سنتناوله في سياق هذه الدراسة.
Attitude to vaccination against COVID-19 in patients with non-psychotic mental disorders
Authors: Khalezova N. B. , Kostyleva Z. E. , Kissin M. Ya. , Boeva E. V. 
Published: January 2024

The COVID-19 pandemic has exacerbated the increasing prevalence of non-psychotic mental disorders and the rise of antivaccination tendencies.The aim of the study was to describe the attitude to vaccination against COVID-19 in patients with non-psychotic mental disorders, as well as in mentally healthy individuals.Materials and methods: a survey was conducted of 100 outpatient patients with psychiatric diagnoses of non-psychotic level: organic mental disorders (14), affective disorders (38), neurotic and stress-related disorders (48), as well as 30 people without mental disorders.Results and discussion. There was no association between the severity of COVID-19 and an adverse reaction to the vaccine. A high incidence of skepticism about vaccination against COVID-19 was noted in women, in the older age group, in people with higher education and highly qualified work, but poorly informed about immunoprophylaxis. Post-vaccination complications (fever, general weakness) after immunization against COVID-19 were more often detected in patients with affective disorders, however, this group of patients showed the most loyal attitude to vaccination. Patients with organic mental disorders shown the lowest degree of approval of vaccination against COVID-19, they cited fear of possible «side effects» and «lack of proven benefit» as the main reason for not being vaccinated.Conclusion. Vaccination of the population of all countries affected by COVID-19 has exacerbated such a phenomenon as doubt about the benefits of immunoprophylaxis. The results of the article can be extrapolated to the future development of new drugs in the field of immunoprophylaxis.
Governance structures and stakeholder’s involvement in Urban Agricultural projects: an analysis of four case studies in France
Authors: Boukharta Ouiam Fatiha , Pena-Fabri Fabiana , Chico-Santamarta Leticia , Navas-Gracia Luis Manuel , Sauvée Loïc 
Published: January 2024

Abstract
Nowadays, there is great pressure in cities on the demand and supply of food as well as environmental needs, and where Urban Agriculture emerges in various forms to confront this situation. Indeed, Urban Agriculture is a form of agriculture, highlighting its multiple functions in ensuring food security, maintaining urban ecosystem services, and improve the quality of life. Moreover, the use and transformation of abandoned areas is proving to be an appropriate way of creating new green spaces. This research article focuses on analysing the alignment between governance mechanisms, the distribution of the value created, together with the benefits derived. The comparison is based on four case studies in France, two in Paris (“La Caverne” and “Veni-Verdi”) and two in Rouen (“Le Champ des Possibles” and “Le Jardin de l’Astéroïde”) with different vocations (social vs economic), and which will serve as a basis for investigations into the theme of Food Governance Structures. This research work consisted of carrying out interviews with the stakeholders involved in Urban Agricultural Projects, as well as on-site visits for analysis and evaluation. An empirical analysis through the NVivo Software is used, which allowed the qualitative analysis of the data. The results show that there are similarities between the different initiatives, such as having a well-structured administrative office headed by a president, treasurer and employees. At the same time, there are a few differences in terms of the type of structure, key priorities and management structure. Indeed, three of the four initiatives evaluated aim to reach out to local residents and to understand the benefits of having agricultural spaces in our cities and to recreate this link with nature, unlike the economic initiative, which focuses more on business and commerce and less on social and educational inclusion.
Penentuan Jalur Mitigasi di Kawasan Jeron Beteng Yogyakarta dengan Metode Mental Mapping
Authors: Widyaningsih Eka , Subangun Radiaswari , Prabowo Rachmat Wahyu 
Published: January 2024

Jeron Beteng merupakan bagian dari wilayah Kraton Yogyakarta yang berada di bagian dalam batas benteng Baluwerti yang berfungsi sebagai area permukiman dengan kepadatan penduduk mencapai 150 jiwa/ha. Pada saat terjadi bencana, kepadatan penduduk ini mengandung potensi korban jiwa yang cukup tinggi. Hal ini menjadi permasalahan utama dalam penanganan mitigasi bencana, terutama dalam proses evakuasi. Sementara itu, mitigasi kebencanaan yang paling ideal terjadi apabila penghuni/korban secara intuitif bergerak ke arah area titik kumpul yang aman. Untuk menentukan titik kumpul yang aman ini perlu kajian identifikasi kawasan dari sudut pandang penggunanya. Di kawasan Jeron Beteng, pengguna dikelompokkan menjadi 3 jenis, yaitu penghuni yang sudah cukup mengenal Kawasan, pengunjung temporer rutin yang sudah terbiasa dengan kawasan tersebut dan wisatawan yang masih asing terhadap kawasan Jeron Beteng. Mental mapping merupakan sebuah metode identifikasi elemen ruang kota yang digagas oleh Kevin Lynch untuk mengenali, mendeskripsikan, dan memetakan pengalaman ruang sebuah kawasan. Metode mental mapping ini digunakan untuk mengidentifikasi 5 elemen kawasan Jeron Beteng yang kemudian diterjemahkan menjadi rencana mitigasi bencana menurut persepsi penggunanya, sehingga dihasilkan jalur evakuasi dan titik kumpul yang mudah dikenali, dijangkau, dan digunakan oleh penggunanya.
Analisis Penerapan Konsep Arsitektur Tropis pada Surabaya C2O Library and Collabtive
Authors: Rivaldy Hikmal , Utomo Heru Prasetiyo 
Published: January 2024

Indonesia khususnya Kota Surabaya merupakan kota yang memiliki iklim tropis dengan suhu tinggi. Arsitektur tropis dapat diterapkan sebagai solusi dari masalah yang disebabkan oleh faktor alam pada desain bangunan daerah tropis. Penelitian ini dilakukan bertujuan untuk menganalisis penerapan arsitektur tropis pada bangunan Surabaya C2O Library and Collabtive. Penelitian menggunakan metode kualitatif deskriptif dengan melakukan check langsung mengamati objek penelitian secara detail dan menilai tingkat tropis bangunan berdasarkan prinsip-prinsip desain arsitektur tropis DR. Ir. RM. Sugiyatmo. seperti kenyamanan termal, kenyamanan visual, orientasi bangunan, area terbuka hijau, dan penggunaan material yang tahan cuaca. Studi mengindikasi bahwa Surabaya C2O Library and Collabtive telah menerapkan desain arsitektur tropis sesuai prinsip desain dengan baik, seperti arah bangunan menghadap ke timur laut, ruang terbuka hijau dengan penyebaran vegetasi di sekitar bangunan, penggunaan material bangunan yang tahan terhadap cuaca seperti beton finishing cat, kayu, bata, kaca, dan alumunium, sirkulasi udara dengan adanya bukaan di berbagai sisi, penerangan alami melalui penggunaan bukaan yang lebar dan skylight, melindungi bangunan terkena cahaya matahari secara langsung yang berlebihan dan hujan lebat, bangunan dilengkapi dengan kanopi, tanaman, dan atap dengan kemiringan curam. Namun, ada beberapa penilaian yang perlu dievaluasi seperti memperluas kanopi atau mengoptimalkan area hijau.
László Dobszay: The World of Tones Solfège Book Series and the Timeliness of the Contemporary Edition
Authors:   Eszterházy Károly Catholic University Music Institute, Eger, Hungary. Email: varady.krisztina@uni-eszterhazy.hu., Várady Krisztina 
Published: January 2024

"The article discusses the necessity of the contemporary	publication of The World of Tones series of solfege books by Dobszay. It outlines the areas of Kodály method that are related to the textbooks and describes the solfege publications in use before the series was published. Keywords: Kodály-method, solfège, music education"
Effect of angiotensin receptor neprilysin inhibitor on physical activity in patients with heart failure with reduced ejection fraction, monitored by implantable electronic device home monitoring
Authors: Volis Ina , Postnikov Maria , Reiner-Benaim Anat , Hellman Yaron , Marcusohn Erez 
Published: January 2024

Aims
Angiotensin receptor neprilysin inhibitor (ARNI) therapy is a cornerstone in the treatment of heart failure with reduced ejection fraction (HFrEF), with significant improvement in mortality as well as morbidity and quality of life. However, maximal ARNI doses often result in hypotension. Recent studies with ‘real world’ experience suggest that lower doses of ARNI are as effective as higher doses.
In order to evaluate the symptomatic effect of low-dose ARNI in HFrEF patients, we analyzed physical activity data obtained via home monitoring of patients with cardiac implantable electronic devices (CIEDs).

Methods
We retrospectively analyzed physical activity data obtained from HFrEF patients with CIED-active home monitoring during the years 2021–2022. Patients with ARNI therapy were further divided into subgroups according to the administered dose. Low-dose ARNI included doses of up to 24/26 mg sacubitril/valsartan daily. Intermediate dose and high dose included doses of 72/78–120/130 mg/day, and 144/156–194/206 mg/day, respectively.

Results
A total of 122 patients had home monitoring-compatible CIEDs and HFrEF during the study period. Sixty-four of these patients were treated with ARNI. Administration of low-dose ARNI resulted in a 20% increase in daily activity when compared with patients without ARNI treatment (P = 0.038). Change in physical activity of patients in the intermediate-dose and high-dose groups was not significant. Younger patients, patients with cardiac resynchronization therapy, and patients without diabetes mellitus were more physically active.

Conclusion
Low-dose ARNI had a beneficial effect on physical activity in HFrEF patients. MH via CIED provided real-life objective data for patients’ follow-up.
Alignment of buccally displaced canines following premolar extractions: archwtre or natural alignment?
Authors: Lew Kenneth 
Published: January 2024

Abstract
The alignment times of buccally displaced maxillary canines following first premolar extractions were studied in 2 groups. The control group (n=28) comprised of cases where no appliances were used while the experimental group (n=28) had Begg brackets bonded on the upper teeth in conjunction with Sentalloy archwire. The imbrication indices (I.I.) of all canines were recorded for both groups prior to extraction and every 5 days after extractions until the canines aligned. The results indicated that there was no significant difference in the alignment rate at 30 days and 60 days between the 2 groups. However, the alignment rates at 90 and 120 days were both significantly faster in the experimental compared to the control group (p < 001). While the alignment rates at 30, 60, 90 and 120 days in the experimental group followed a plateaued curve, the alignment rates in the control group followed a cusped curve. The results indicated that a 2 months self-alignment period following premolar extractions would be justified in most cases before banding.
Hypodontia in the permanent dentition: a study of its prevalence in Malaysian children
Authors: Nik-Hussein Nik Moriah 
Published: January 2024

Abstract
An investigation of the prevalence and distribution of hypodontia was carried out in Malaysian children between the ages of five to fifteen years. Hypodontia occurred in 2.8 per cent of these children. A greater number of females were found to have hypodontia, the ratio of affected females to males is 1.6:1. The teeth most frequently missing were the maxillary lateral incisors followed by the mandibular lateral incisors, then the mandibular second premolars. The aetiology of the condition is discussed. It is noteworthy that studies showing the lower second premolars to be most commonly missing have younger subjects. This suggests delayed development of these teeth in some individuals.
First report of prunus necrotic ringspot virus infecting rose (Rosa spp.) in Lebanon
Authors: Abou Kubaa R. , Choueiri E. , Jreijiri F. , Minafra A. 
Published: January 2024

Summary
Prunus necrotic ringspot virus (PNRSV) was detected in several rose plants showing symptoms of rose mosaic disease (RMD) in Beqaa valley, Lebanon. PNRSV was found in 29 plants by molecular and serological analyses, while other viruses associated with RMD were absent. Although PNRSV is known to have a wide host range, the present paper reports the first occurrence of PNRSV on rose plants in Lebanon.
New data on the scale insect pests of Ephedra foeminea in Greece
Authors: Stathas G.J. , Skouras P.J. , Kartsonas E.D. , Darras A.I. 
Published: January 2024

Summary
The dioecious gymnosperm self-sown ornamental plant Ephedra foeminea Forssk (Ephedraceae: Gnetales) has a special interest due to its nutraceutical and pharmaceutical properties. The present study contributes with data about the phenology of the plant in Attica, Greece, and the complex of its scale insect pests (Hemiptera: Coccomorpha), Stotzia ephedrae (Newstead) (Coccidae) (morphology, phenology, biology, natural enemies), Dynaspidiotus ephedrarum (Lindinger) (morphology, natural enemies) and Leucaspis riccae Targioni Tozzetti (Diaspididae) (natural enemies), based on observations made from April 2021 to June 2023. Stotzia ephedrae which was the scale species found in higher numbers on E. foeminea is a univoltine, oviparous and biparental species recorded as settled 1st instar nymph on the shoots of E. foeminea from May to January. The fecundity of the scale fluctuated between 370 and 598 eggs per female. The results on the phenology of S. ephedrae contribute to the knowledge of the critical period for the pest control, i.e. from May to January during which the scale remains in the sensitive first instar. In addition, the records of parasitoids and predators in the colonies of the scale insects infesting E. foeminea provide information on the available natural enemies for potential use in biological control schemes of these pests.