bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elimination of 15N-thymidine after oral administration in human infants
Authors: Ammanamanchi Niyatie , Yester Jessie , Bargaje Anita P. , Thomas Dawn , Little Kathryn C. , Janzef Shannon , Francis Kimberly , Weinberg Jacqueline , Johnson Jennifer , Seery Thomas , Harris Tyler Hutchinson , Funari Bryan J. , Rose-Felker Kirsten , Zinn Matthew , Miller Susan A. , West Shawn C. , Feingold Brian , Zhou Hairu , Steinhauser Matthew L. , Csernica Timothy , Michener Robert , Kühn Bernhard 
Published: January 2024

Background
We have developed a new clinical research approach for the quantification of cellular proliferation in human infants to address unanswered questions about tissue renewal and regeneration. The approach consists of oral 15N-thymidine administration to label cells in S-phase, followed by Multi-isotope Imaging Mass Spectrometry for detection of the incorporated label in cell nuclei. To establish the approach, we performed an observational study to examine uptake and elimination of 15N-thymidine. We compared at-home label administration with in-hospital administration in infants with tetralogy of Fallot, a form of congenital heart disease, and infants with heart failure.

Methods
We examined urine samples from 18 infants who received 15N-thymidine (50 mg/kg body weight) by mouth for five consecutive days. We used Isotope Ratio Mass Spectrometry to determine enrichment of 15N relative to 14N (%) in urine.

Results/findings
15N-thymidine dose administration produced periodic rises of 15N enrichment in urine. Infants with tetralogy of Fallot had a 3.2-fold increase and infants with heart failure had a 4.3-fold increase in mean peak 15N enrichment over baseline. The mean 15N enrichment was not statistically different between the two patient populations (p = 0.103). The time to peak 15N enrichment in tetralogy of Fallot infants was 6.3 ± 1 hr and in infants with heart failure 7.5 ± 2 hr (mean ± SEM). The duration of significant 15N enrichment after a dose was 18.5 ± 1.7 hr in tetralogy of Fallot and in heart failure 18.2 ± 1.8 hr (mean ± SEM). The time to peak enrichment and duration of enrichment were also not statistically different (p = 0.617 and p = 0.887).

Conclusions
The presented results support two conclusions of significance for future applications: (1) Demonstration that 15N-thymidine label administration at home is equivalent to in-hospital administration. (2) Two different types of heart disease show no differences in 15N-thymidine absorption and elimination. This enables the comparative analysis of cellular proliferation between different types of heart disease.
A nomogram for predicting mortality risk within 30 days in sepsis patients admitted in the emergency department: A retrospective analysis
Authors: Wang Bin , Chen Jianping , Pan Xinling , Xu Bingzheng , Ouyang Jian 
Published: January 2024

ObjectiveTo establish and validate an individualized nomogram to predict mortality risk within 30 days in patients with sepsis from the emergency department.MethodsData of 1205 sepsis patients who were admitted to the emergency department in a tertiary hospital between Jun 2013 and Sep 2021 were collected and divided into a training group and a validation group at a ratio of 7:3. The independent risk factors related to 30-day mortality were identified by univariate and multivariate analysis in the training group and used to construct the nomogram. The model was evaluated by receiver operating characteristic (ROC) curve, calibration chart and decision curve analysis. The model was validated in patients of the validation group and its performance was confirmed by comparing to other models based on SOFA score and machine learning methods.ResultsThe independent risk factors of 30-day mortality of sepsis patients included pro-brain natriuretic peptide, lactic acid, oxygenation index (PaO2/FiO2), mean arterial pressure, and hematocrit. The AUCs of the nomogram in the training and verification groups were 0.820 (95% CI: 0.780–0.860) and 0.849 (95% CI: 0.783–0.915), respectively, and the respective P-values of the calibration chart were 0.996 and 0.955. The DCA curves of both groups were above the two extreme curves, indicating high clinical efficacy. The AUC values were 0.847 for the model established by the random forest method and 0.835 for the model established by the stacking method. The AUCs of SOFA model in the model and validation groups were 0.761 and 0.753, respectively.ConclusionThe sepsis nomogram can predict the risk of death within 30 days in sepsis patients with high accuracy, which will be helpful for clinical decision-making.
Costs incurred by people with co-morbid tuberculosis and diabetes and their households in the Philippines
Authors: Yamanaka Takuya , Castro Mary Christine , Ferrer Julius Patrick , Solon Juan Antonio , Cox Sharon E. , Laurence Yoko V. , Vassall Anna 
Published: January 2024

Objective
Diabetes is a risk factor for TB mortality and relapse. The Philippines has a high TB incidence with co-morbid diabetes. This study assessed the pre- and post-TB diagnosis costs incurred by people with TB and diabetes (TB-DM) and their households in the Philippines.

Methods
Longitudinal data was collected for costs, income, and coping mechanisms of TB-affected households in Negros Occidental and Cebu, the Philippines. Data collection was conducted four times during TB treatment. The data collection tools were developed by adapting WHO’s cross-sectional questionnaire in the Tuberculosis Patient Cost Surveys: A Handbook into a longitudinal study design. Demographic and clinical characteristics, self-reported household income, number of facility visits, patient costs, the proportion of TB-affected households facing catastrophic costs due to TB (>20% of annual household income before TB), coping mechanisms, and social support received were compared by diabetes status at the time of TB diagnosis.

Results
530 people with TB were enrolled in this study, and 144 (27.2%) had TB-DM based on diabetes testing at the time of TB diagnosis. 75.4% of people with TB-DM were more than 45 years old compared to 50.3% of people with TB-only (p<0.001). People with TB-DM had more frequent visits for TB treatment (120 vs 87 visits, p = 0.054) as well as for total visits for TB-DM treatment (129 vs 88 visits, p = 0.010) compared to those with TB-only. There was no significant difference in the proportion of TB-affected households facing catastrophic costs between those with TB-DM (76.3%) and those with TB-only (68.7%, p = 0.691).

Conclusion
People with TB-DM in the Philippines face extensive health service use. However, this does not translate into substantial differences in the incidence of catastrophic cost. Further study is required to understand the incidence of catastrophic costs due to diabetes-only in the Philippines.
Severe Dysphagia With Eosinophilic Esophagitis Pattern of Injury Related to Pembrolizumab Therapy
Authors: Barnett James S. , Yu Kevin K. , Rivera Rivera Xavier , Bhatt Asmeen 
Published: January 2024

ABSTRACT
While immune checkpoint inhibitor (ICI) therapies are effective treatments for many cancers, ICI therapies are associated with immune-related adverse events. We present a 67-year-old man with non–small cell lung carcinoma, who developed severe dysphagia with biopsies from an esophagogastroduodenoscopy showing histopathology consistent with eosinophilic esophagitis while on ICI maintenance therapy with pembrolizumab. The patient's symptoms worsened despite standard therapy. However, he had complete resolution of dysphagia symptoms once pembrolizumab was discontinued. While immune-related adverse events affecting the gastrointestinal system are increasingly recognized, ICI-associated eosinophilic esophagitis is a rare entity.
Acute-on-Chronic Liver Failure Incited by Cyclin-Dependent Kinase Inhibitor Therapy for Breast Cancer Effectively Treated With Liver Transplantation
Authors: Kalas Vasilios , Nguyen Jessica , Wan Alan W. , Dietch Zachary C. , Kulik Laura , Hughes Dempsey L. 
Published: January 2024

ABSTRACT
Cyclin-dependent kinase 4/6 inhibitors are targeted therapies demonstrated to significantly improve overall survival as adjuvant treatment of estrogen receptor-positive breast cancers. Although intended to preferentially arrest cell cycle transitions in tumor cells, these agents can have undesirable systemic side effects, including hepatotoxicity. We report the first case of cyclin-dependent kinase 4/6 inhibitor therapy leading to acute-on-chronic liver failure requiring liver transplantation. Our case highlights the multidisciplinary approach required to manage acute-on-chronic liver failure induced by cancer-directed therapies in those with extrahepatic malignancies.
Prospects of using the microRNA expression level and parameters of nucleolar organizer regions in the choice of surgical tactics for follicular thyroid tumor of uncertain malignant potential
Authors: Kazachkov E. L. , Il'ina T. E. , Sergijko S. V. 
Published: January 2024

BACKGROUND: According to modern concepts [1], microRNAs modulate the expression of eukaryotic genes with different oncogenetic directions of action. according to the data from the scientifi literature [2–4], microRNA-146b, -199b can be used for typing thyroid neoplasms, -221, -223, -31, -375, -451a, -551b, etc. Nucleolar organizers (NOR) are sections of chromosomes that form a nucleolus inside the cell nucleus [5–7]. The condition of the regions of nucleolar ribosome organizers (AgNORs) is a marker of the rate of cell proliferation, since they are involved in the regulation of the mitotic cycle [8], and in thyroid pathology [9].AIM: To evaluate the diagnostic significance of the level of expression of some microRNAs and the number of regions of nucleolar organizers in thyroid tissue in the case of follicular thyroid tumor of uncertain malignant potential (FT-UMP) to objectify approaches to the validity of the chosen surgical tactics.MATERIALS AND METHODS: In our study of 3960 patients with surgery due to various thyroidopathies in 2018–2021 on the basis of the thyroid center of Chelyabinsk. 2063 patients were operated on for tumor pathology. In this group, in 98 cases (the study group), FT-UMP was diagnosed based on morphological criteria of neoplasm [10]. This accounted for 4.75% of all surgical tumor pathology during this time. The study group studied the profile, the level of microRNA expression by real-time PCR and the regions of nucleolar organizers in 98 cases of FT-UMP, which amounted to 4.75% of all those operated for thyroid tumors over four years.RESULTS: In 29 (29.6%) cases, a microRNA spectrum characteristic of malignant neoplasms was registered in the tumor tissue. In the remaining 69 (70.4%) cases out of 98 observations, the spectrum and level of microRNA expression corresponded to follicular adenoma. Statistically significant differences in the average number of AgNORs and the ratio between the cell area and the number of AgNORs granules were revealed within the formed subgroups. The study found that an increase in the average number of AgNORs and the ratio of the core area to the number of silver nitrate granules in the 2nd subgroup relative to the 1st, as well as the presence of type II cells indicates the appearance of proliferating tumor cells in the neoplasm and can be considered as prognostic criteria for tumor malignancy. These results are consistent with the obtained indicators of molecular genetic research CONCLUSION: The data can serve as additional criteria for assessing the proliferative activity of the follicular epithelium in thyroid neoplasia. Including clarifying the potential of malignancy. The conditionally malignant variant diagnosed before the operation will justify the need and scope of surgical intervention, and when identifying a set of criteria for conditionally benign HPV, it can be recommended to adhere to wait-and-see tactics.
Prediction of the development of hypocalcemia in primary hyperparathyroidism patients 1–3 days after radical parathyroidectomy
Authors: Elfimova A. R. , Eremkina A. K. , Rebrova O. Yu. , Kovaleva E. V. , Mokrysheva N. G. 
Published: January 2024

BACKGROUND: It was impossible to predict the development of hypocalcemia following parathyroidectomy (PTE) in patients with primary hyperparathyroidism (PHPT) until now. Hypocalcemia may be accompanied by myalgia, generalized seizures up to tetany, and arrhythmias. Hypocalcemia following PTE can be prevented by preoperative cholecalciferol supplementation. However, patients with severe hypercalcemia above 3 mmol/L do not receive vitamin D due to the risk of hypercalcemia progression. Despite the existing data showing the safety of cholecalciferol therapy in case of mild elevation of serum calcium, not all patients are prescribed vitamin D supplementation, probably due to the lack of a suitable tool to assess the postoperative hypocalcemia risks.AIM: To design a mathematical model and a software tool for predicting hypocalcemia 1–3 days post-PTE in PHPT patients using the patient’s demographic and clinical data, laboratory test results and preoperative therapy status.MATERIALS AND METHODS: This retrospective study included 478 PHPT patients diagnosed with adenomas and carcinomas of the parathyroid gland (PTG) who underwent radical PTE between 1993–2010 or 2018–2020 at the Endocrinology Research Centre. The following parameters were analyzed: sex; age; laboratory markers prior to calcimimetic and antiresorptive therapy: PTH, total calcium, phosphorus; osteocalcin (OC), alkaline phosphatase (ALP), C-terminal telopeptide of type 1 collagen. Also we analyzed 25-hydroxyvitamin D (25(OH)D); bone mineral density (BMD) measured by X-ray densitometry; medical history of low-energy fractures; preoperative therapy with denosumab, bisphosphonates, cinacalcet, cholecalciferol. Categorical gradient boosting (CatBoost) was built to predict the risk of postoperative hypocalcemia.RESULTS: The prevalence of severe osteoporosis is higher in the postoperative hypocalcemia group compared to the nonhypocalcemia group (27% vs. 15%), wherein the frequency of preoperative administration of cholecalciferol in this group is lower (8% vs. 25%). A CatBoost model was built to predict postoperative hypocalcemia using 13 predictors (sex, age, PTH, serum total calcium, phosphorus, OC, BMD reduction, 25(OH)D, administration of cholecalciferol, bisphosphonates, denosumab, and cinacalcet. The proposed model http://194.87.111.169/hypocalcemia for post-PTE hypocalcemia in PHPT patients achieved the following metrics: positive predictive value 73.3%-86.7%; negative predictive value 74.9%-89.3%.CONCLUSION: The model can be used to choose the appropriate preand postoperative approaches for patients who undergo rPTE.
Partial slice regularity and Fueter's theorem in several quaternionic variables
Authors: Binosi Giulio 
Published: January 2024

Abstract
We extend some definitions and give new results about the theory of slice analysis in several quaternionic variables. The sets of slice functions that are slice, slice regular, and circular with respect to given variables are characterized. We introduce new notions of partial spherical value and derivative for functions of several variables that extend those of one variable. We recover some of their properties as circularity, harmonicity, some relations with differential operators, and a Leibniz rule with respect to the slice product as well as studying their behavior in the context of several variables. Then, we prove our main result, which is a generalization of Fueter’s theorem for slice regular functions in several variables. This extends the link between slice regular and axially monogenic functions well known in the one variable context.
Life online during the pandemic : How university students feel about abrupt mediatization
Authors: Zylinski Szymon , Davis Charles H. , Vladica Florin 
Published: January 2024

Abstract
The COVID-19 pandemic caused university education to transition from face-to-face contacts to virtual learning environments. Young adults were forced to live an entirely new life online, without valuable and enjoyable social interaction. We examined subjective perspectives towards life online during the pandemic. We identified four viewpoints about life mediated by computers. Two viewpoints express “struggling”: Viewpoint 1 (Angry, Depressed and Overwhelmed), and Viewpoint 3 (Restricted to and Overwhelmed by Virtuality). A third feeling-state conveys experiences of “surviving”: Viewpoint 4 (Isolated and Powerless in Convenience). Surprisingly, Viewpoint 2 is about “thriving” (Comfortable and Convenient Routine with Computers). The research shows that virtualization, confinement, and anxiety are taking a toll on the mental health of some members of the younger generation, while at the same time other members feel they are thriving in a situation of limited resources, virtuality, and reduced face-to-face human interaction.
Exploring the Role of Civic Monitoring of Coal Ash Pollution: (Re)gaining Agency by Crowdsourcing Environmental Information
Authors: Berti Suman Anna , Burnette Amelia 
Published: January 2024

Abstract
Citizen-gathered evidence (CGE) gathered by individuals organized in collectives have the potential to demonstrate environmental and social wrongdoings in court. We identify (collective) agency and resistance in how individuals and communities that have been exposed to socio-environmental stressors turn to gather CGE. We explore the modes through which people gather scientific data, produce CGE, alert authorities to environmental harm, and the methods by which data can be shared with communities, beginning with the case studies of civic environmental monitoring addressing coal ash pollution in North Carolina. We analyze the case studies through a theoretical lens built on (1) the theory of civic monitoring “as resistance;” (2) the argument that CGE can embody “collective intelligence;” and (3) the concept of “crowd science” through a decentralized yet coordinated network. In the first part of the article, we introduce the case studies. Then, we illustrate our theoretical frame as applied to the analysis of the cases. We discuss the cases and in particular the CGE at issue through the prism of the frame. We demonstrate how CGE can be valuable not only for civil society and civic organizations, but also for competent authorities. In our conclusion, we identify critical junctures of our case studies, such as that of “knowledge crowdsourcing” to demand justice that triggers the government to take action and the existence of a “coordinated” yet decentralized crowd to capture the full extension of the problem. Lastly, we outline the limitations of our study, a future research agenda, and still open questions.
Microstructural characterization of 15Cr steel after quenching and slow cooling rates
Authors: Ahmadi M. R. , Meixner F. , Dománková M. , Raus M. , Sonderegger B. , Sommitsch C. 
Published: January 2024

Abstract
Ferritic 15 %-Cr steels have better oxidation resistance, due to their higher chromium content, and creep strength, their lower dislocation density and lack of lath microstructure than conventional martensitic steels such as MarBN. Their mechanical properties are sensitive to chemical composition and heat treatment. In this study, we first simulated the formation of stable phases in two ferritic steels containing 2 % nickel (wt.%) and an alloy without nickel using the thermomechanical software MATCALC. Microstructural analysis using scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDS) reveals the formation of carbides and intermetallic phases after diffusion annealing, both during rapid cooling in oil and slow cooling in the furnace. Dilatometry and XRD studies confirm the gradual phase transformation of ferrite to austenite from 650 °C onwards during heating. Dilatometry also shows that ferritic steels have a lower coefficient of thermal expansion than martensitic steels, austenitic steels, and superalloys, which results in lower thermal stresses during frequent start-up and shutdown of power plants.
Psychische Probleme im Kontext von Religiosität und Spiritualität. Eine Literaturanalyse zu Typologien und Erscheinungsbildern
Authors: Hofmann Liane 
Published: January 2024

Zusammenfassung
Ein stetig wachsendes Angebot an religiösen und spirituellen (r/s) Weganleitungen und Praktiken wird von einer zunehmenden Zahl von Individuen in den westlichen Gesellschaften rege in Anspruch genommen. Während r/s Glaubensüberzeugungen, Gruppenzugehörigkeiten und Praktiken vielfältige salutogene Wirkungen haben können, so kann unter diversen abträglichen Kontextbedingungen auch ein breites Spektrum an problematischen und krisenhaften psychischen Reaktionen daraus erwachsen. Derartige Probleme und Krisen im Kontext der r/s Entwicklung, Orientierung und Praxis sind in den vergangenen drei Jahrzehnten zunehmend in den Fokus des klinisch-psychotherapeutischen Interesses gerückt. Der Beitrag gibt einen orientierenden Überblick über wesentliche Entwicklungen auf diesem Forschungsgebiet. Es werden prominente Typologien psychischer Probleme im Kontext von Religiosität und Spiritualität (R/S) vorgestellt und deren jeweilige Schwerpunktsetzungen diskutiert. Der Beitrag schließt mit einer Reflexion der Faktoren, die zu einer angemessenen und effektiven Begleitung von Menschen in problematischen psycho-religiösen oder psycho-spirituellen Prozessen beitragen.
Automated football match reports as models of textuality
Authors: Meier-Vieracker Simon 
Published: January 2024

Abstract
This paper deals with automated football match reports as a common genre of automated journalism. Based on a corpus of automated and human-written reports (n = 1,302) on the same set of matches and with reference to linguistic concepts of text and textuality, the textual properties of these texts are analyzed both quantitatively and qualitatively. The analysis is based on the idea that the task of text generation can be described as the task of automatically selecting cues of textuality such as connectives or signals of thematic relatedness. The results show that automated and human-written texts differ significantly in the use of these cues, particularly in the use of linguistic means for creating evaluation and contrast, and thus allow to trace in detail, how these cues contribute to cohesion, coherence and narrative qualities. Different from computational linguistic approaches focused on optimizing text generation algorithms, this paper proposes to use automated texts, which are to some extent imperfect, as models of textuality that through their imperfection can say something about the nature of texts in general. The paper thus contributes to the field of (mostly communication studies) research on automated journalism in which the texts themselves are rarely investigated.