bluuebunny/crossref_metadata_2025_split huggingface dataset:
Based on Serum Pharmacochemistry and Virtual Screening Technique
Analysis Used to Explore the Potential Active Ingredients and Possible Anti-
Coronary Heart Disease Mechanisms of Salvia miltiorrhiza Bunge
Authors: Shi Yuhe , Li Qing , Zhu Jue , Hou Chao wen , Li Xiao ling , Liu Xiang dan , Tong Qiao zhen 
Published: January 2024

Aims and Objective::
This study aimed to identify the bioactive compounds and explore
the multi-target mechanisms of Salvia miltiorrhiza Bunge (SMB) against coronary heart
disease (CHD) using an integrated serum pharmacochemistry and network pharmacology approach.

Materials and Methods::
The chemical constituents of SMB were characterized by UPLC-MS.
The absorbed ingredients and metabolites after oral SMB administration were identified in rat
serum. Therapeutic targets of SMB against CHD were predicted by intersecting the targets of
absorbed compounds from databases and CHD-associated genes. Protein-protein interaction network,
pathway analysis, molecular docking, and molecular dynamic simulation were performed.

Results::
A total of 61 SMB-derived compounds were identified in rat serum. Network analysis
revealed 111 candidate targets highly related to CHD pathways. Further topological analysis
identified 10 hub targets and 20 key active compounds, constructing an informative compoundtarget-
pathway network. PTGS2 and TNF were predicted as primary targets of SMB against
CHD based on molecular dynamic simulation.

Conclusion::
This integrated approach identified bioactive compounds and multi-target mechanisms
of SMB against CHD. The results provide scientific evidence supporting SMB's clinical
efficacy and reveal potential anti-CHD targets.
Reactions and Biological Activities of Hydrazonoyl Halides
Authors: Alarbash Munirah F. , Al-Faiyz Yasair S. , Wiggins Jeffrey S. , Sayed Abdelwahed R. 
Published: January 2024

Abstract:
This review covers the literature information on the chemistry of hydrazonoyl halides with
different substrates to give heterocyclic compounds. From the foregoing survey, it seems this provides
a useful and convenient strategy for the synthesis of numerous heterocyclic derivatives. The subject of
such reactions is still ongoing and undoubtedly will provide new fused functionalized compounds of
both industrial and biological interest. A literature survey revealed that a great deal of interest has been
focused on the synthesis of functionalized heterocyclic compounds due to their wide range of biological
activities, such as contact dermatitis, anthelmintic, antiviral, antimicrobial, herbicidal, and anti-cancer.
On the other hand, hydrazonoyl halides are interesting synthons for valuable bioactive heterocyclic
compounds. The reaction of hydrazonoyl halides with various types of substrates gave a huge number
of different heterocyclic systems. In this review, we collected all reactions of hydrazonoyl halides with
different moieties and classified them as aryl diazo of monoheterocycles, aryldiazo of 5,5-bis-heterocycles,
aryldiazo of 5,6-bis-heterocycles, aryldiazo of 6,6-bis-heterocycles, aryldiazo of 5,5,6-tri-heterocycles,
aryldiazo of 5,6,6-tri-heterocycles, aryldiazo of 6,6,6-tri-heterocycles, hetero annulation of bisheterocycles,
hetero annulation of tri-heterocycles, hetero-annulation of tetra-heterocycles, synthesis of
spiro-heterocycles, heterocyclic ring transformations, and 1,3-dipolar cycloaddition reactions catalyzed
by transition metals using hydrazonoyl halides as substrates.Most reaction types have been successfully
applied and used in the production of biologically active compounds.

:
The aim of the present survey is to consider in the reader the opportunity interactions and biological
activities of hydrazonoyl halides. The information of several artificial paths and varied physics-chemical
factors of such heterocycles made a special consideration of chemists in different fields to yield
a combinatorial library and carry out thorough efforts in the search for hydrazonoyl halides.
Structure-based Virtual Screening from Natural Products as Inhibitors of
SARS-CoV-2 Spike Protein and ACE2 Receptor Binding and their
Biological Evaluation In vitro
Authors: Delgado-Maldonado Timoteo , Gonzalez-Morales Luis Donaldo , Juarez-Saldivar Alfredo , Lara-Ramírez Edgar E. , Rojas-Verde Guadalupe , Moreno-Rodriguez Adriana , Bandyopadhyay Debasish , Rivera Gildardo 
Published: January 2024

Background:
In the last years, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) caused more than 760 million infections and 6.9 million deaths. Currently, remains
a public health problem with limited pharmacological treatments. Among the virus drug
targets, the SARS-CoV-2 spike protein attracts the development of new anti-SARS-CoV-2 agents.

Objective:
The aim of this work was to identify new compounds derived from natural products
(BIOFACQUIM and Selleckchem databases) as potential inhibitors of the spike receptor binding
domain (RBD)-ACE2 binding complex.

Methods:
Molecular docking, molecular dynamics simulations, and ADME-Tox analysis were
performed to screen and select the potential inhibitors. ELISA-based enzyme assay was done to
confirm our predictive model.

Results:
Twenty compounds were identified as potential binders of RBD of the spike protein. In
vitro assay showed compound B-8 caused 48% inhibition at 50 μM, and their binding pattern exhibited
interactions via hydrogen bonds with the key amino acid residues present on the RBD.

Conclusion:
Compound B-8 can be used as a scaffold to develop new and more efficient antiviral
drugs.
Hepatitis E Virus in Individuals Undergoing Heparin Therapy: An
Observational Serological and Molecular Study
Authors: Mesquita João R. , Santos-Silva Sérgio , Ferreira Nanci , Rivero-Juarez Antonio , Gonçalves Guilherme , São José Nascimento Maria 
Published: January 2024

Introduction::
Heparin is derived from swine and has been suggested as a possible
source of HEV. To study the potential risk of HEV infection associated with heparin treatment,
two groups of individuals were compared. Sera from heparinized (N=93) and non-heparinized
individuals (N=111) were tested for markers of acute HEV infection and anti-HEV IgG seroprevalence.

Method::
An acute HEV case was defined by the presence of anti-HEV IgM and/or HEV RNA.
From the 93 heparinized individuals, one was positive for IgM and IgG anti-HEV and two were
positive for HEV RNA (for both ORF3 and ORF2), and there were a total of two (2.2%) cases of
current or recent HEV infection. From the 111 non-heparinized individuals, three were positive
for IgM anti-HEV, one was positive for both IgM and IgG anti-HEV, and none was positive for
HEV RNA, and there were a total of three (2.7%) cases of current or recent HEV infection. The
difference between HEV cases in the heparinized individuals and the non-heparinized individuals
was not statistically significant (2.2% vs. 2.7%; p = 0.799).

Results::
Concerning IgG anti-HEV, it was detected in 32 individuals from the heparinized group
and in 18 from the non-heparinized control group. A statistically significant difference was observed
in the presence of anti-HEV IgG in heparinized individuals and controls (p = 0.003).

Conclusion::
This study has not found any association between heparin treatment and acute HEV
infection, but has shown the use of therapeutic heparin as a risk factor for IgG anti-HEV seropositivity.
Tumor Necrosis Alpha (TNF-α) Antagonists Used in Chronic Inflammatory
Rheumatic Diseases: Risks and their Minimization Measures
Authors: Lakhmiri Rim , Cherrah Yahia , Serragui Samira 
Published: January 2024

Abstract:
Tumor necrosis factor alpha (TNF- α) inhibitors are widely employed for the management of chronic inflammatory rheumatism. However, their usage carries significant risks, including site and infusion reactions, serious infections, malignancy, heart failure autoimmune and
demyelinating disorders. These risks are comprehensively outlined in risk management plans
(RMPs) associated with these molecules. RMP provides information on the safety profile of a
medicinal product as well as the measures that will be taken to minimize risks; these are known
as risk minimization measures. These measures are divided into routine measures related to elements, such as the summary of product characteristics, labeling, pack size, package leaflet, or
legal supply status of the product, while additional measures may include educational programs,
including tools for healthcare providers and patients, controlled access or pregnancy prevention
programs, among others. Additional measures can consist of one or more interventions that need
to be implemented in a sustainable way in a defined target group, while respecting the timing
and frequency of any intervention and procedures to reach the target population. An evaluation
of the effectiveness of these measures is required to determine whether or not an intervention
has been effective. This comprehensive review offers an in-depth exploration of the current
treatment, uses, and associated risks of TNF-α inhibitors. Additionally, it provides a detailed account of risk minimization measures and risk management practices while shedding light on
their real-world implementation and effectiveness.
Turmeric Extract-loaded Selenium Nanoparticles Counter Doxorubicin-induced
Hepatotoxicity in Mice via Repressing Oxidative Stress, Inflammatory Cytokines, and
Cell Apoptosis
Authors: ALRashdi Barakat M. , Hussein Mohamed M. , Mohammed Rawan M. , Abdelhamed Nada W. , Asaad Maran E. , Alruwaili Mubarak , Alrashidi Saad M. , Habotta Ola A. , Abdel Moneim Ahmed E. , Ramadan Shimaa S. 
Published: January 2024

Background:
Doxorubicin (DOX) is an antitumor anthracycline used to treat a variety of malignancies;
however, its clinical use is associated with noticeable hepatotoxicity. Therefore, the current study was designed
to delineate if biosynthesized SeNPs with turmeric extract (Tur-SeNPs) could alleviate DOX-induced
hepatic adverse effects.

Methods:
Mice were orally post-treated with Tur extract, Tur-SeNPs, or N-acetyl cysteine after the intraperitoneal
injection of DOX.

Results:
Our findings have unveiled a remarkable liver attenuating effect in DOX-injected mice post-treated with
Tur-SeNPs. High serum levels of ALT, AST, ALP, and total bilirubin induced by DOX were significantly decreased
by Tur-SeNPs therapy. Furthermore, Tur-SeNPs counteracted DOX-caused hepatic oxidative stress,
indicated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and
mRNA expression levels of Nrf-2. Noteworthily, decreased hepatic IL-1β, TNF-α, and NF-κB p65 levels in addition
to downregulated iNOS gene expression in Tur-SeNPs-treated mice have indicated their potent antiinflammatory
impact. Post-treatment with Tur-SeNPs also mitigated the hepatic apoptosis evoked by DOX injection.
A liver histological examination confirmed the biochemical and molecular findings.

Conclusions::
In brief, the outcomes have demonstrated Tur loaded with nanoselenium to successfully mitigate
the liver damage induced by DOX via blocking oxidative stress, and inflammatory and apoptotic signaling.
Mirror Symmetry Coils for Foreign Object Detection and Location with Wireless Power Transmission
Authors: Xu Yuhui , Xu Jin 
Published: January 2024

Background:
Wireless power transmission technology effectively avoids safety issues
caused by accidental contact, wire aging, and friction. However, due to the presence of foreign
objects, other severe accidents such as fire hazard can occur, and the charging system can be interfered
with and even damaged by the foreign objects.

background:
As a new charging technology, the wireless power transmission (WPT) technology has shown some favorable application prospects on safety, reliability, and convenience.

Method:
Therefore, this paper proposes (MSD) mirror symmetry detection coils to detect and locate
foreign objects. First, we conduct theoretical analysis and derive formulas to validate our
proposed method. Next, we employ ANSYS Maxwell to simulate the (WPT) wireless power
transmission system, considering various sizes and materials of foreign objects and comparing
them to a system without foreign objects. Result: Furthermore, we conducted experiments using
mirror symmetrical detection coils to detect and locate foreign objects, providing additional verification
for our proposed method.

Conclusion:
The simulation and experimental results show that the proposed method of mirror
symmetry detection coils can effectively identify and locate the foreign objects.
Optimisation of conservative treatment of patients with severe heart failure by using hemosorption
Authors: Denysiuk K.V. 
Published: January 2024

Background. Heart failure (HF) is a complex cardiac pathology that is the main cause of hospitalisation among adults and is characterised by a high mortality. Dilated cardiomyopathy (DCM) is the most common cause of HF, and it can be fatal within a few years after the first symptoms appear. Many patients with HF remain refractory to medical therapy, despite its constant development and improvement. The study aims to compare the effectiveness of conservative treatment of patients with severe HF that occurred on the background of DCM using drug therapy and its combination with a course of hemosorption (HS). Materials and methods. We analysed treatment outcomes in 30 patients with severe HF against DCM (New York Heart Association class III–V, left ventricular ejection fraction (LV EF) < 30 %). Patients in group 1 (n = 13; N-terminal fragment of brain natriuretic peptide precursor (NT-pro BNP) 4,546.23 ± ± 3,265.01 pg/ml; LV EF 16.77 ± 2.92 %; LV end-diastolic volume (EDV) 261.31 ± 60.60 ml, LV end-systolic volume (ESV) 214.85 ± 49.44 ml) received drug therapy according to local protocols. In group 2 (n = 17; NT-pro BNP 3,974.49 ± 3,550.17 pg/ml; LV EF 18.18 ± 4.36 %; LV EDV 261.12 ± 79.96 ml, LV ESV 212.06 ± 71.67 ml), medical treatment was supplemented with a course of 3 HS procedures using granular deligandizing hemosorbent. Results. Patients in both study groups noted an improvement in well-being and a decrease in the severity of symptoms. The level of NT-pro BNP decreased to 2,609.92 ± 1,465.14 pg/ml (p < 0.01) in group 1 and to 975.35 ± 511.55 pg/ml (p < 0.05) in group 2. LV EF increased to 22.77 ± 4.69 % and 26.76 ± 5.02 %, respectively, in the groups (p < 0.01). In patients of group 1, LV EDV and LV ESV changed to 262.22 ± 40.92 ml and 211.33 ± 35.22 ml, respectively. In group 2, there was a significant decrease in LV EDV to 228.94 ± 73.16 ml and LV ESV to 170.88 ± 60.28 ml (p < 0.01). Conclusions. The use of HS in combination with drug therapy for severe HF on the background of DCM improves the clinical status of patients and LV systolic function.
ECG changes and their prognostic value for the development of sudden cardiac death in HCM patients
Authors: Tseluyko V.Y. , Butko O.O. 
Published: January 2024

Background. Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease characterized by an increase in the left ventricular (LV) wall thickness, which is not explained only by abnormal loading conditions. The development of sudden cardiac death (SCD) is one of the most dangerous complications of HCM. The aim of our study was to evaluate the prognostic value of electrocardiography (ECG) changes for the development of SCD in the Ukrainian population of patients with HCM. Materials and methods. We evaluated 350 patients with HCM who were examined in the City Clinical Hospital 8 (Kharkiv, Ukraine) from 2006 to 2021. The diagnosis of HCM was made in accordance with the current guidelines of the European Society of Cardiology. Clinical and instrumental data of patients with HCM were analyzed retrospectively, including general clinical data, 12-lead ECG, echocardiography, Holter monitoring, calculation of the 5-year risk of SCD according to the HCM Risk-SCD tool. The endpoint of the study was SCD and its surrogates, including adequate performance of the implantable cardioverter-defibrillator and the state after a successful resuscitation. Results. Follow-up was 5.0 (1.5–9.5) years. During this time, 16 patients (4.6 %) reached the endpoint, which was 0.9 %/year. According to the HCM Risk-SCD, 5 (31.3 %) patients in this group were at a high (≥ 6 %) and 3 (18.8 %) were at an intermediate risk of SCD (≥ 4 and < 6 %). A multivariable Cox regression analysis has shown that independent predictors of SCD are syncope (hazard ratio (HR) 3.81, 95% confidence interval (CI) 1.11–13.12, p = 0.034), systolic blood pressure (HR 0.97, 95% CI 0.94–0.99, p = 0.026), ECG with “infarction-like” ST elevation (HR 6.81, 95% CI 2.09–22.16, p = 0.001) and PQ interval value (HR 1.03, 95% CI 1.01–1.05, p = 0.002), Harrell’s C-index (HR 0.84, 95% CI 0.73–0.95, p < 0.0001). Conclusions. The proposed HCM Risk-SCD tool was not effective enough in predicting SCD in our study. In order to improve the risk stratification, ECG changes (“infarction-like” ST elevation and PQ interval prolongation) and systolic blood pressure lowering can be used, which were found to be independent predictors of SCD risk.
BUDAYA PATRIARKI DALAM IKLAN SARIWANGI VERSI ‘SAATNYA BICARA, SAATNYA SARIWANGI #MARIBICARA’ (ANALISIS SEMIOTIKA ROLAND BARTHES)
Authors: Kamilah Alfiyya Hasna 
Published: January 2024

Pada 18 Januari 2021 SariWangi mengiklankan produknya dengan muatan konteks patriarki dalam kehidupan keluarga pasangan muda berjudul ‘Saatnya Bicara, Saatnya SariWangi #MariBicara’ di YouTube. Iklan ini menggunakan pendekatan slice of life dengan mengambil konflik mengenai isu kesetaraan gender dalam dinamika berkeluarga. Penelitian ini bertujuan untuk membongkar ideologi patriarki di unit keluarga yang bekerja pada tanda-tanda di balik iklan yang mengarah pada terjadinya konstruksi makna mitos. Teori semiotika Roland Barthes diterapkan dalam penelitian ini untuk mencari makna pesan yang disampaikan melalui tanda-tanda dalam iklan ini. Desain penelitian ini menggunakan paradigma kritis dengan pendekatan kualitatif menggunakan metode analisis semiotika Barthes. Data penelitian diperoleh melalui observasi untuk mencari unit analisis yang digunakan dalam penelitian ini. Hasil penelitian yang didapat melalui proses signifikasi dua tahap yang dipahami dalam istilah denotasi dan konotasi ditemukan sejumlah tanda yang mengarah pada mitos berupa mitos maskulinitas dan domestikasi. Namun, di sini iklan dikonstruksikan sebagai media kritik terhadap patriarki privat. Hal tersebut ditunjukkan dengan adanya penyadaran gender yang dibangun iklan tersebut melalui tahap penyelesaian konflik berupa tindakan yang dinilai salah dengan meleburkan mitos tersebut. Dari iklan SariWangi tersebut dapat diketahui bentuk resistensi terhadap sakleknya budaya patriarki dalam sistem masyarakat.
TWITTER: REPRESENTASI DAN EKSPRESI DIRI TANPA SEKAT
Authors: Aisha Emeralda , Bahalwan Halida 
Published: January 2024

Twitter merupakan platform media sosial yang mempromosikan pembicaraan publik, dimana para pengguna bisa saling berinteraksi satu sama lain tanpa sekat yang berarti. Lingkungan Twitter ini membuat para pengguna merepresentasikan dirinya dengan cara yang berbeda-beda tergantung dengan tujuan penggunaan mereka dalam menggunakan Twitter sebagaimana dijelaskan oleh konsep Ekologi Media. Untuk itu, penelitian ini berupaya melihat bagaimana representasi dan ekspresi diri para pengguna Twitter yang dipengaruhi oleh berbagai fitur yang ada di Twitter. Tujuan yang hendak dicapai dari penelitian ini antara lain: (1) Mengetahui Twitter mempengaruhi representasi diri pengguna (2) Menjelaskan Twitter sebagai media teknologi membentuk cara berkomunikasi tertentu bagi para pengguna. Penelitian ini merupakan micro research, yang dilakukan secara kualitatif kepada 10 orang pengguna Twitter dengan metode random sampling. Hasil penelitian menunjukan representasi diri yang dilakukan oleh para pengguna Twitter tidak terlepas dari bagaimana Twitter membebaskan para penggunanya untuk berekspresi dan karakter Twitter yang cepat dan up to date.
Pengaruh Literasi Digital dan Orientasi Kewirausahaan Terhadap Kinerja Usaha Di Sentra Industri Rajut Binong Jati Bandung
Authors: Kartika Dewi , Ratnamiasih Ina 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh Literasi Digital dan Orientasi Kewirausahaan terhadap Kinerja Usaha baik secara simultan maupun secara parsial di Sentra Industri Rajut Binong Jati Bandung. Metode penelitian yang digunakan yaitu metode deskriptif dan verifikatif dengan jumlah sampel sebanyak 201 responden. Sedangkan untuk teknik pengumpulan data yang digunakan dalam penelitian ini yaitu observasi, wawancara dan penyebaran kuesioner. Dan untuk metode analisis yang digunakan meliputi regresi linier berganda, korelasi berganda dan koefisien determinasi. Hasil dari penelitian ini menunjukan bahwa terdapat pengaruh positif dan signifikan secara simultan maupun secara parsial. Secara simultan pengaruh Literasi Digital dan Orientasi Kewirausahaan terhadap Kinerja Usaha sebesar 71,6% Secara parsial Literasi Digital memberikan pengaruh sebesar 53,2% terhadap Kinerja Usaha, dan Orientasi Kewirausahaan memberikan pengaruh sebesar 18,4% terhadap Kinerja Usaha, dapat disimpulkan bahwa Literasi Digital dan Orientasi Kewirausahaan memiliki pengaruh yang signifikan terhadap Kinerja Usaha di Sentra Industri Rajut Binong Jati Bandung.
DAMPAK STRUKTUR MODAL TERHADAP PROFITABILITAS PERUSAHAAN (STUDI KASUS PT SRI REJEKI ISMAN TBK TAHUN 2017-2022)
Authors: Hermawan Muhammad 
Published: January 2024

The purpose of this study is to determine the impact of capital structure on company profitability. The method used in this research uses quantitative methods with a descriptive approach, the type of data used in this study is quantitative data. The data source used in this study is secondary data. Secondary data is a source of research data obtained by researchers indirectly through intermediary media obtained. Secondary data is a source of research data obtained by researchers indirectly through intermediary media obtained. The technique of collecting research data is by documentation method. The data sources used in this study are from the Indonesia Stock Exchange (IDX) and annual financial reports. Population is a generalization consisting of objects / subjects that have certain qualities and characteristics that are determined by researchers to be studied and then drawn conclusions. The results of a simple regression analysis test using a partial t test showed a capital structure value of 0.201 which is greater than the predetermined significance therapy of 0.05, then this has no significant relationship or influence on the dependent variable y profitability, then in this variable H0 is accepted and Ha is rejected. The cause of no significance or no influence or relationship of capital structure variables on profitability can be caused by other variables not mentioned in this study and various other internal and external factors that have nothing to do with this study
PENGARUH DIVIDEND PAYOUT RATIO DAN DIVIDEND YIELD TERHADAP HARGA SAHAM PADA INDEKS LQ45
Authors: Bagaskara Doni , Rohmadi Rohmadi 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh dividend payout ratio dan dividend yield terhadap harga saham pada Indeks LQ45. Penelitian ini menggunakan metode kuantitatif, objek penelitian menggunakan data sekunder 45 perusahaan yang terdaftar di Indeks LQ45 tahun 2023, penelitian ini memakai model teknik pengumpulan sampel dengan non-probability sampling atau non-random sampel. Sumber data berasal dari data dan dokumen IDX Company LQ45 tahun 2023 di Bursa Efek Indonesia (BEI). Proses analisis menggunakan analisis regresi berganda data cross section dibantu oleh SPSS 2023. Hasil penelitian ini menyatakan bahwa dividend payout ratio tidak berpengaruh terhadap harga saham, sedangkan dividend yield berpengaruh positif terhadap harga