bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anaesthetic considerations and challenges during awake craniotomy
Authors: Tang Leonard , Tan Tong Khee 
Published: February 2024

Abstract
This article summarises the key anaesthetic considerations and challenges surrounding the perioperative management of a patient undergoing awake craniotomy. The main goals include patient comfort, facilitation of patient cooperation during the critical awake phase and maintenance of optimal operating conditions. These are achieved through appropriate patient selection and preparation, familiarity with the complexity of each surgical phase and potential complications that may arise, as well as maintenance of close communication among all team members. Challenges such as loss of patient cooperation, loss of airway, intraoperative nausea and vomiting, seizures, cerebral oedema, hypertension, blood loss and use of intraoperative magnetic resonance imaging are discussed. The importance of teamwork, competence, vigilance and clear management strategies for potential complications to maximise patient outcomes is also highlighted.
A comprehensive review on corneal crosslinking
Authors: Naranjo Andrea , Manche Edward E. 
Published: February 2024

Abstract:
Corneal crosslinking (CXL) represents a paradigm shift in the management of corneal ectatic disorders. Before CXL was introduced, patients would need specialty contact lenses and possible corneal transplantation. CXL involves a biochemical reaction in which ultraviolet A light is used in conjunction with Riboflavin to form crosslinks in between corneal stromal collagen. This leads to strengthening and stabilizing of the collagen lamellae, resulting in mechanical stiffening of the cornea. Multiple protocols have been proposed including epithelium on versus off and varying light intensity and duration of treatment. All protocols appear to be safe and effective with few reported complications including infection, stromal haze, scarring, and endothelial toxicity. Overall, CXL has demonstrated to halt the progression of the disease clinically and in keratometry readings and improve the quality of life for patients. It is a minimally invasive, cost-effective procedure that can be performed in an outpatient setting with a fast recovery time and long-lasting results.
Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases
Authors: Song Hua-Chuan , Zhou Hang-Cheng , Gu Ping , Bao Bing , Sun Quan , Mei Tian-Ming , Cui Wei , Yao Kang , Yao Huan-Zhang , Zhang Shen-Yu , Wang Yong-Shuai , Song Rui-Peng , Wang Ji-Zhou 
Published: February 2024

BACKGROUND
Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality, with the liver being the primary organ of metastasis. Preoperative chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases (CRLMs). Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of chemotherapy. However, the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative chemotherapy. Body mass index (BMI) is one of the factors affecting the tumorigenesis and progression of colorectal cancer as well as prognosis after various antitumour therapies. Several studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight, particularly when receiving first-line chemotherapy regimens in combination with bevacizumab.
AIM
To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for CRLMs.
METHODS
A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July 2023. Univariate and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological response. The Kaplan-Meier method with log rank test was used to compare progression-free survival (PFS) between patients with high and low BMI. BMI < 24.0 kg/m2 was defined as low BMI, and tumour regression grade 1-2 was defined as complete tumour response.
RESULTS
Low BMI was observed in 74 (58.7%) patients and complete tumour response was found in 27 (21.4%) patients. The rate of complete tumour response was significantly higher in patients with low BMI (29.7% vs 9.6%, P = 0.007). Multivariate analysis revealed that low BMI [odds ratio (OR) = 4.56, 95% confidence interval (CI): 1.42-14.63, P = 0.011], targeted therapy with bevacizumab (OR = 3.02, 95%CI: 1.10-8.33, P = 0.033), preoperative carcinoembryonic antigen level < 10 ng/mL (OR = 3.84, 95%CI: 1.19-12.44, P = 0.025) and severe sinusoidal dilatation (OR = 0.17, 95%CI: 0.03-0.90, P = 0.037) were independent predictive factors for complete tumour response. The low BMI group exhibited a significantly longer median PFS than the high BMI group (10.7 mo vs 4.7 mo, P = 0.011).
CONCLUSION
In CRLM patients receiving preoperative chemotherapy, a low BMI may be associated with better tumour response and longer PFS.
Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer
Authors: Rong Yao , Tang Ming-Zheng , Liu Song-Hua , Li Xiao-Feng , Cai Hui 
Published: February 2024

BACKGROUND
A growing number of clinical examples suggest that coronavirus disease 2019 (COVID-19) appears to have an impact on the treatment of patients with liver cancer compared to the normal population, and the prevalence of COVID-19 is significantly higher in patients with liver cancer. However, this mechanism of action has not been clarified.
AIM
To investigate the disease relevance of COVID-19 in liver cancer.
METHODS
Gene sets for COVID-19 (GSE180226) and liver cancer (GSE87630) were obtained from the Gene Expression Omnibus database. After identifying the common differentially expressed genes (DEGs) of COVID-19 and liver cancer, functional enrichment analysis, protein-protein interaction network construction and screening and analysis of hub genes were performed. Subsequently, the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was constructed.
RESULTS
Of 518 common DEGs were obtained by screening for functional analysis. Fifteen hub genes including aurora kinase B, cyclin B2, cell division cycle 20, cell division cycle associated 8, nucleolar and spindle associated protein 1, etc. , were further identified from DEGs using the “cytoHubba” plugin. Functional enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation, cell cycle and other functions, and they may serve as potential molecular markers for COVID-19 and liver cancer. Finally, we selected 10 of the hub genes for in vitro expression validation in liver cancer cells.
CONCLUSION
Our study reveals a common pathogenesis of liver cancer and COVID-19. These common pathways and key genes may provide new ideas for further mechanistic studies.
Hepatomegaly and jaundice as the presenting symptoms of systemic light-chain amyloidosis: A case report
Authors: Zhang Xu , Tang Fei , Gao Yan-Ying , Song De-Zhao , Liang Jing 
Published: February 2024

BACKGROUND
Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic production and extracellular tissue deposition of fibrillar proteins derived from immunoglobulin AL fragments secreted by a clone of plasma cells, which leads to progressive dysfunction of the affected organs. The two most commonly affected organs are the heart and kidneys, and liver is rarely the dominant affected organ with only 3.9% of cases, making them prone to misdiagnosis and missed diagnosis.
CASE SUMMARY
A 65-year-old woman was admitted with a 3-mo history of progressive jaundice and marked hepatomegaly. Initially, based on enhanced computed tomography scan and angiography, Budd-Chiari syndrome was considered and balloon dilatation of significant hepatic vein stenoses was performed. However, additional diagnostic procedures, including liver biopsy and bone marrow-examination, revealed immunoglobulin kapa AL amyloidosis with extensive liver involvement and hepatic vascular compression. The disease course was progressive and fatal, and the patient eventually died 5 mo after initial presentation of symptoms.
CONCLUSION
AL amyloidosis with isolated liver involvement is very rare, and can be easily misdiagnosed as a vascular disease.
The impact of the COVID-19 lockdown on child and adolescent active play in Argentina
Authors: Tuñón Ianina , Laíño Fernando , Weisstaub Gerardo 
Published: February 2024

Child and adolescent overweight and obesity are a multifactorial pandemic social problem; however, there is consensus on its link with a higher caloric intake than expenditure. In this context, it is relevant to analyze the propensity to insufficient physical activity in childhood, and in particular the effects of COVID-19 lockdown on active play.
A comparative analysis of the deficit of active play at a prepandemic time and in the period of exit from the strictest isolation in Argentina (2018; 2020) was conducted with 5479 and 3964 observations, respectively, of children between five and 17 years old. The measurements correspond to the Argentine Social Debt Survey (EDSA for its acronym in Spanish) on a national probability sample. First, a descriptive statistical analysis was performed, followed by a multivariate analysis based on logistic regressions. Active play decreased more among females than males as age and socioeconomic status rose. This decline was prominent among those with less physically active parents, a preference for sedentary screen time, and a lower inclination for structured physical activities. Lockdown measures, particularly in working-class neighbourhoods, appeared to shield children's active play. The pandemic and its restrictions harmed children's well-being through diminished play opportunities, affecting their physical, motor, psychological, and social health. Play is widely recognized as a vital bridge between physical activity and energy expenditure. It notably addresses the rising concern of childhood overweight and obesity. Thus, active play becomes a crucial behavior to promote in all circumstances, aligned with a comprehensive health perspective.
Keywords: active play, childhood and adolescence, integral health, obesity, COVID-19
Prejuízos da implementação do ensino remoto para os cursos de graduação em Terapia Ocupacional
Authors: Gomes Ana Beatriz dos Santos , Silva Gabriela Massaro Ribeiro da , Cardoso Gabriela Pissante , Pfeifer Luzia Iara 
Published: February 2024

Introdução: Atualmente, o curso de Terapia Ocupacional no Brasil mantém-se majoritariamente em modalidade presencial, priorizando as aulas práticas e os estágios presenciais como formas de ensino essenciais para o aluno compreender o real funcionamento prático da profissão. Todavia, a utilização da modalidade de ensino remoto, impulsionados pelo isolamento da pandemia da COVID-19, têm gerado preocupações sobre o aprendizado do curso. Objetivo: Avaliar os prejuízos da implementação do ensino remoto e as possíveis implicações para os cursos de graduação em Terapia Ocupacional de universidades brasileiras, através da percepção de discentes e docentes da área. Métodos: Estudo exploratório por meio de levantamento de dados, com abordagem quanti-qualitativa, utilizando Formulário Google®. Os dados foram contabilizados, analisando as concepções e opiniões dos participantes sobre os prejuízos gerados pelo ensino remoto no aprendizado destes. Resultados: Foram contatadas 32 universidades, contando com 216 participantes, sendo 178 discentes e 38 docentes. Do total de respostas, 72,8% foram classificadas e utilizadas como base para a análise. Entre os discentes, 58,7% afirmaram que o ensino remoto causa prejuízo na formação acadêmica e profissional, e 44% dos docentes destacaram o prejuízo na interação social. Conclusões: O aumento de discussões sobre a oferta de cursos da saúde em modalidade remoto, fomentadas pela implementação emergencial do ensino remoto, devem ser desmotivadas, buscando evidenciar o caráter preocupante e prejudicial da implementação desta modalidade nos cursos da área da saúde, que necessitam de atividades e intervenções práticas em conjunto com docentes, pacientes e pares.
Palavra-chave: Ensino Online. Terapia Ocupacional. Aprendizagem.
Pooperacinių antriniu būdu gyjančių žaizdų priežiūra: literatūros apžvalga
Authors: Povilaikaitė Gustė , Gierasimovič Zita 
Published: February 2024

Abstract. According to the World Health Organisation (WHO) ‘Half the cases of post-operative hard-to-heal wounds can be avoided’ [1]. Foreign authors A. E. Boniakowski, A. S. Kimball, B. N. Jacobs, et al. (2017) state that ‘Wound monitoring and periodic post-operative wound care performed at periodically planned time are important at all stages of wound healing’ [2].
Objective of the literature review. To analyse scientific articles on risk factors and wound management of hard-to-heal wounds.
Methods. The literature review was conducted using the PubMed, ECDC, and Google Scholar search in the electronic MEDLINE database. The search was carried out between September and December 2023. Keyword phrases and their combinations were used for the search. Twenty three articles on the examined topic were included in the literature review.
Results of the literature review. The present article discusses the main risk factors for wound infection and preventive measures. After analysing scientific articles, the causes of hard-to-heal wounds have been elucidated, which depend on the nature of the surgery, different pathogenic microorganisms, and the selection of dressings at each stage of wound healing.
Conclusions. 1. Favourable conditions must be created for wound healing. Regular assessment of the wound healing process based on clinical indicators is attributed to an important factor. 2. Topical antimicrobial agents are used when wound healing is suspected to be impaired; dressings are selected based on the type of wound healing.
An Integrated Fishery Meteorological Information Service Terminal Based on End-Side Deep Learning Technology
Authors: Zhao Xiaolong , Fu Xueqian , Zeng Xiangrong , Zhang Ningyi 
Published: February 2024

Fishery meteorology has multiple impacts on the fisheries industry, especially in modern fishery industrial parks where renewable energy is extensively utilized. Therefore, this study developed a comprehensive fishery meteorological information terminal, based on the Android system, that considers the requirements of fish farming, fishery load, and the characteristics of renewable energy for fishery meteorology. This terminal aims to provide convenient and comprehensive information services to aquaculturists actively involved in modernizing the fisheries industry. The system consists of two main subsystems: the fishery subsystem and the weather subsystem. In the fishery subsystem, real-time monitoring and recording of fishery meteorology and related parameters can be achieved. In the weather subsystem, the demand for photovoltaic energy in weather forecasting is emphasized. A weather prediction model based on LSTM is used for hourly weather forecasting. The model is trained on meteorological station data by default, and users can also upload photovoltaic station data to obtain a model trained on such data. The system can retain two models simultaneously, and when one of the datasets is unavailable, the available data is used to make predictions on the corresponding model to ensure service stability. Additionally, we conducted experiments to verify the performance loss brought by deploying the model on the edge using TensorFlow Lite. The results show that when the memory usage is reduced to 1/33 of the original, the model still retains over 99% of its performance.

Received: 1 October 2023 | Revised: 19 November 2023 | Accepted: 25 January 2024

Conflicts of Interest
Xueqian Fu is an Editorial Board Member for Artificial Intelligence and Applications, and was not involved in the editorial review or the decision to publish this article. The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support the findings of this study are openly available in WF_DATA at http://doi.org/10.5281/zenodo.10575481.

Author Contribution Statement
Xiaolong Zhao: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Visualization. Xueqian Fu: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Supervision, Project administration, Funding acquisition. Xiangrong Zeng: Methodology, Software, Investigation, Resources, Data curation, Writing - original draft. Ningyi Zhang: Methodology, Software, Investigation, Resources, Data curation, Writing - original draft.
Reablement of Instrumental Activities of Daily Living for Patients With Stroke: A Randomized Crossover Trial
Authors: Chen Pei-Tsen , Chiu En-Chi 
Published: February 2024

Abstract
Importance: Reablement is a person-centered and goal-oriented rehabilitative intervention to optimize people’s chances to live independently.
Objective: To investigate the effects of a reablement intervention on performance of instrumental activities of daily living (IADLs) in three aspects (i.e., actual performance, ability, and self-perceived difficulty) for patients with stroke.
Design: A single-blinded, randomized crossover study.
Setting: Participants’ home and community.
Participants: Twenty-seven patients with stroke.
Interventions: Each participant received two interventions (IADL reablement and health education). Each intervention was administered for 6 wk. All participants were randomly assigned to one intervention and then received the other intervention after a 4-wk washout period.
Outcomes and Measures: Outcomes of actual performance and self-perceived difficulty were derived from the Frenchay Activities Index (FAI) and the difficulty dimension of the Participation Measure–3 Domains, 4 Dimensions (PM–3D4D), respectively. Outcomes of ability were measured with the Lawton Instrumental Activities of Daily Living Scale (LIADL) and the Canadian Occupational Performance Measure Performance score (COPM Performance).
Results: No statistically significant differences were found in the three aspects between the IADL reablement and health education (ps = .148–.570). Compared with the health education, the IADL reablement showed better improvements on the FAI, LIADL, COPM Performance, and difficulty dimension of the PM–3D4D with trivial to small effect sizes (ds = 0.17–0.45).
Conclusions and Relevance: Our results reveal that the IADL reablement has the potential to increase the frequency of IADL administration, enhancing the capability to perform IADLs and reducing the self-perceived difficulty of carrying out IADLs.
Plain-Language Summary: The results of this study showed positive outcomes for a reablement intervention that focuses on goal-oriented instrumental activities of daily living for patients with stroke. An IADL reablement intervention may be useful for improving the ability to carry out IADL tasks at home and in the community.
Roles of Handedness and Hemispheric Lateralization: Implications for Rehabilitation of the Central and Peripheral Nervous Systems: A Rapid Review
Authors: Dexheimer Brooke , Sainburg Robert , Sharp Sydney , Philip Benjamin A. 
Published: February 2024

Abstract
Importance: Handedness and motor asymmetry are important features of occupational performance. With an increased understanding of the basic neural mechanisms surrounding handedness, clinicians will be better able to implement targeted, evidence-based neurorehabilitation interventions to promote functional independence.
Objective: To review the basic neural mechanisms behind handedness and their implications for central and peripheral nervous system injury.
Data Sources: Relevant published literature obtained via MEDLINE.
Findings: Handedness, along with performance asymmetries observed between the dominant and nondominant hands, may be due to hemispheric specializations for motor control. These specializations contribute to predictable motor control deficits that are dependent on which hemisphere or limb has been affected. Clinical practice recommendations for occupational therapists and other rehabilitation specialists are presented.
Conclusions and Relevance: It is vital that occupational therapists and other rehabilitation specialists consider handedness and hemispheric lateralization during evaluation and treatment. With an increased understanding of the basic neural mechanisms surrounding handedness, clinicians will be better able to implement targeted, evidence-based neurorehabilitation interventions to promote functional independence.
Plain-Language Summary: The goal of this narrative review is to increase clinicians’ understanding of the basic neural mechanisms related to handedness (the tendency to select one hand over the other for specific tasks) and their implications for central and peripheral nervous system injury and rehabilitation. An enhanced understanding of these mechanisms may allow clinicians to better tailor neurorehabilitation interventions to address motor deficits and promote functional independence.
Occupational Therapy Practice Guidelines for Adults Living With Alzheimer’s Disease and Related Neurocognitive Disorders
Authors: Smallfield Stacy , Metzger Lizabeth , Green Melissa , Henley Laura , Rhodus Elizabeth K. 
Published: February 2024

Abstract
Importance: There are currently 55 million adults living with declining functional cognition—altered perception, thoughts, mood, or behavior—as the result of Alzheimer’s disease (AD) and related neurocognitive disorders (NCDs). These changes affect functional performance and meaningful engagement in occupations. Given the growth in demand for services, occupational therapy practitioners benefit from consolidated evidence of effective interventions to support adults living with AD and related NCDs and their care partners.
Objective: These Practice Guidelines outline effective occupational therapy interventions for adults living with AD and related NCDs and interventions to support their care partners.
Method: We synthesized the clinical recommendations from a review of recent systematic reviews.
Results: Twelve systematic reviews published between 2018 and 2021 served as the foundation for the practice recommendations.
Conclusion and Recommendations: Reminiscence, exercise, nonpharmacological behavioral interventions, cognitive therapy, sensory interventions, and care partner education and training were found to be most effective to support adults living with AD and related NCDs.
Plain-Language Summary: These Practice Guidelines provide strong and moderate evidence for occupational therapy practitioners to support adults living with Alzheimer’s disease (AD) and related neurocognitive disorders (NCDs) and their care partners. They provide specific guidance for addressing the decline in cognition, behavioral and psychological symptoms of dementia, and pain experience of adults living with AD and related NCDs. The guidelines also describe interventions to support care partners. With support from the evidence, occupational therapy practitioners are better equipped to address the unique needs of adults living with AD and related NCDs and their care partners.