bluuebunny/crossref_metadata_2025_split huggingface dataset:
An institutional experience in applying quality improvement measures to pituitary surgery: clinical and resource implications
Authors: Pelargos Panayiotis E. , Hasanjee Aamr , Lee Benjamin , Grossen Audrey , Prather Kiana Y. , Zhao Xiaochun , Ohene-Nyako Prince , Baier Matthew P. , McDaniel Amanda Kate , McKinney Kibwei A. , Graffeo Christopher S. , El Rassi Edward , Dunn Ian F. 
Published: December 2023

OBJECTIVE
The aim of this study was to report the authors’ experience developing a Lean Six Sigma clinical care pathway (CCP) for endoscopic endonasal transsphenoidal operations.

METHODS
Using Lean Six Sigma quality improvement principles—including the define, measure, analyze, improve, and control framework—the authors developed a CCP for endoscopic endonasal transsphenoidal operations, incorporating preoperative, intraoperative, and inpatient and outpatient postoperative phases of care. Efficacy and quality metrics were defined as postoperative length of stay (LOS), presentation to the emergency department (ED) or readmission within 30 days of discharge, and hospital charges. The study included all adult patients who underwent elective endoscopic endonasal resection for pituitary adenoma, Rathke’s cleft cyst, craniopharyngioma, pituicytoma, or arachnoid cyst during the sampling period (April 1, 2018, to December 31, 2022).

RESULTS
Two hundred twenty-eight patients met criteria and were included; 94 were treated before and 134 were treated after implementation of the CCP. Differences between groups in age, gender, race, BMI, American Society of Anesthesiologists classification, geographic distribution, preoperative serum sodium, tumor size, adenoma functional status, and prior surgery were not significant. The mean postoperative LOS significantly decreased from 4.5 to 1.7 days following CCP implementation (p < 0.0001); LOS variability also decreased, with the standard deviation declining from 3.1 to 1.5 days. The proportion of patients discharged on postoperative day (POD) 1 significantly increased from 0% to 61.9% (p < 0.0001). Fewer than one-quarter of the patients (23.4%) were discharged by POD 2 prior to the CCP, while 88.8% of were discharged by POD 2 after CCP implementation (p < 0.0001). Rates of 30-day ED presentations or readmissions were not significantly different (2.1% vs 6.0%, p = 0.20, and 7.5% vs 6.7%, p > 0.99, respectively). Mean per-patient hospital costs declined from $38,326 to $26,289 (p < 0.0001), with an associated change in cost variability from a standard deviation of $16,716 to $12,498.

CONCLUSIONS
CCP implementation significantly improved LOS and costs of endoscopic endonasal resection, without adversely impacting postoperative ED presentations or readmissions.
«The Eschatology of Hope» by H. U. von Balthazar: Between Infernalism and Universalism
Authors: Солонченко Александр Александрович 
Published: December 2023

Это вторая статья автора, посвящённая эсхатологической концепции Г. У. фон Бальтазара. В ней рассматривается ответ Бальтазара на критику со стороны приверженцев универсалистских и инферналистских взглядов. В первой части статьи описывается бальтазаровская интерпретация эсхатологических мест Нового Завета. Во второй части автор указывает на главное отличие эсхатологии надежды Бальтазара от учения об апокатастасисе. В третьей части статьи воспроизводятся представления о Боге в инфернализме. Далее автор приводит ответ Бальтазара на вопрос: на что смеет надеяться христианин? В следующей части рассматриваются рассуждения Бальтазара о том, как праведники могут блаженствовать в раю, созерцая муки грешников в аду. Далее в центре внимания автора вопрос о соотношении надежды на спасение всех и проблемы свободы. Также в статье рассматриваются взгляды Бальтазара на тему Страшного Суда, ада и окончательной судьбы диавола. В последней части статьи автор приводит оценки эсхатологической концепции Бальтазара, данные разными исследователями, и заключает, что его учение вызывает ряд вопросов.
This is the second article by the author dedicated to the eschatological concept of H. U. von Balthasar. In this article, the author examines the response to the criticism of the concept of Balthasar by the adherents of universalist and infernalist views. The first part of the article provides a description of Balthazar’s interpretation of the eschatological passages of the New Testament. In the second part, the author points out the main difference between Balthasar’s «eschatology of hope» and the doctrine of apocatastasis. The third part of the article reproduces ideas about God in infernalism. Further, the author gives Balthazar’s answer to the question: what does a Christian dare to hope for? In the next part, Balthazar’s arguments on the topic are considered: how is the bliss of the righteous in Paradise possible, contemplating the torments of sinners in hell? Further, the focus of the author's attention is the question of the relationship between the hope for the salvation of all and the problem of freedom. The article also discusses Balthazar’s views on the theme of the Last Judgment, hell and the final fate of the devil. In the last part of the article, the author gives assessments of the eschatological concept of Balthasar by various researchers and concludes that it raises a number of questions.
Biotecnologia inovando na indústria
Authors: Alves Akyla Anara Frota Lima , Malosso Milena Gaion 
Published: December 2023

A biotecnologia industrial, classificada como branca, é uma área altamente relevante que utiliza organismos vivos, como bactérias e fungos, para produzir uma variedade de produtos industriais de maneira mais eficiente e sustentável. Esta área é representada pela cor branca porque representa a pureza e a eficiência dos processos envolvidos. Uma das aplicações mais proeminentes da biotecnologia branca é a produção de produtos químicos industriais, plásticos biodegradáveis, enzimas e biopolímeros. Além disso, a engenharia genética desempenha um papel fundamental na biotecnologia branca, permitindo a criação de microrganismos geneticamente modificados (OGMs) que são especialmente projetados para produzir produtos industriais desejados de forma mais eficaz. Outro aspecto importante da biotecnologia branca é a biorremediação, que envolve o uso de microrganismos para remover poluentes e substâncias tóxicas do meio ambiente. Isso é particularmente relevante para a indústria química e de resíduos. Em resumo, a biotecnologia branca é uma área inovadora que desempenha um papel fundamental na transformação da indústria, tornando-a mais limpa, mais eficiente e mais sustentável. Ela demonstra como a aplicação de princípios biológicos pode revolucionar a produção industrial, ao mesmo tempo em que reduz o impacto ambiental, contribuindo para um futuro industrial mais responsável e ecologicamente consciente.
Teste de sensibilidade de solventes utilizados na diluição de extratos vegetais com potencial antimicrobiano sobre staphylococcus epidermidis
Authors: Silva Sharleane Souza da , Pereira Mateus da Silva , Chamy Michel Nasser Corrêa Lima 
Published: December 2023

Dentre os desafios encontrados nas pesquisas voltadas para estudo da atividade antimicrobiana de extratos vegetais, pode-se destacar a dificuldade em encontrar soluções que possam diluir os extratos vegetais com eficiência sem apresentar toxicidade celular frente aos organismos testados. Objetivo: Avaliar a atividade antimicrobiana de solventes utilizados na química de produtos naturais frente a bactéria Staphylococcus epidermidis. Metodologia: Foram selecionados 10 soluções amplamente utilizadas para diluir extratos vegetais em teste bactericidas ou bacteriostáticos: Água destilada; Álcool (50%, 70%, 92%); Hexano P.A.; Tween (20 e 80) e DMSO (1%, 50%, P.A.). O ensaio foi desenvolvido de acordo com o método disco-difusão, onde os discos de papel filtro de 6 mm estéril foram embebecidos com as soluções selecionados, em seguida os mesmo foram submetido a secagem em temperatura ambiente por 20 minutos e posteriormente posicionados em placa de Petri com meio Mueller Hinton Ágar cultivado com a bactéria Staphylococcus epidermidi. O antibiótico Clorafenicol (30,0 µg) foi usado como controle. Ademais, as placas foram incubadas em estufa B.O.D a 37°C por 24 horas. O surgimento de halos de inibição foi verificado. Resultados: O antimicrobiano (controle), as soluções DMSO P.A. e TWEEN 20 apresentaram halo de inibição. Conclusões: Seguindo o procedimento de secagem em temperatura ambiente, com exceção do DMSO P.A. e TWEEN 20, as demais soluções testadas apresentaram possibilidade de crescimento microbianos nas concentrações testadas.
Biotecnologia vermelha: inovação médica e terapêutica
Authors: Alves Akyla Anara Frota Lima , Malosso Milena Gaion 
Published: December 2023

A biotecnologia vermelha é um segmento vital da biotecnologia que se concentra na aplicação de avanços científicos e tecnológicos para resolver problemas médicos e melhorar a saúde humana. Esta área dinâmica engloba uma ampla gama de aplicações, desde o desenvolvimento de medicamentos inovadores até terapias genéticas revolucionárias, com o objetivo final de aliviar o sofrimento humano e prolongar a vida. Um dos aspectos mais proeminentes da aplicação biotecnológica à saúde é a pesquisa e o desenvolvimento de novos medicamentos. Isso inclui a identificação de alvos terapêuticos, a síntese de moléculas farmacêuticas e a realização de ensaios clínicos rigorosos para garantir a segurança e eficácia dos tratamentos. Muitos medicamentos que salvam vidas, como vacinas e terapias para doenças crônicas, foram desenvolvidos por meio da biotecnologia vermelha. Além disso, a terapia genética é uma área em crescimento na biotecnologia vermelha. Ela envolve a modificação de genes defeituosos para tratar doenças genéticas raras e complexas. As terapias genéticas oferecem a promessa de cura para condições antes consideradas incuráveis. A biotecnologia vermelha também está intimamente relacionada à pesquisa médica, ao diagnóstico molecular e à medicina personalizada. Esses avanços têm o potencial de revolucionar a maneira como abordamos a saúde, tornando os tratamentos mais eficazes e direcionados às necessidades individuais. Por fim a biotecnologia vermelha desempenha um papel fundamental na melhoria da saúde humana. Seja na criação de novos medicamentos, no desenvolvimento de terapias inovadoras ou na pesquisa médica de ponta, essa área continua a moldar o futuro da medicina e da biotecnologia de maneira impactante.
Buying And Selling Orders In The Kitab Al-Jami' Sahih Muslim: A Study Of Takhrij
Authors: Syaichoni Ahmad 
Published: December 2023

Kitab Al-Jami', better known as Kitab Sahih Muslim, is a famous kutub al-sittah. This book is attributed to Al-Imam Abu al-Husain Muslim ibn al-Hajjaj al-Qusyairi al-Naisaburi, better known as Imam Muslim. This book discusses hadiths in various spheres of life, such as aqidah, worship, and muamalah. This paper traces the muamalah's study of buying and selling orders in the Muslim Sahih Book. One transaction that has developed along with the advancement of information and technology is buying and selling orders, known as bay' al-salam. Bay al-salam transactions in the modern era are used in online buying and selling transactions. This paper seeks to trace how the position of buying and selling greetings in the hadith of the Prophet is contained in the Book of Sahih Muslim. This paper uses literature research using the takhrij hadith method. The takhrij hadith method is used with a thematic approach (maudhu'i). The results showed that the hadith about buying and selling orders is in the hadith 'aziz with muttasil. The matan of this hadith does not contradict the intellect and postulates of the Qur'an. Order buying and selling transactions in their actualization experience differences in criteria applied in Islamic bank financing products and online buying and selling or e-commerce. Greeting transactions are not only in agriculture but also include various products with a cash payment system at the beginning of the transaction.
Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy
Authors: Kelly Tanya E. , Spillane Cathy L. , Ward Mark P. , Hokamp Karsten , Huang Yanmei , Tewari Prerna , Martin Cara M. , Norris Lucy A. , Mohamed Bashir M. , Bates Mark , Brooks Robert , Selemidis Stavros , Brooks Douglas A. , Kamran Waseem , Saadeh Feras Abu , O’Toole Sharon A. , O’Leary John J. 
Published: December 2023

Introduction: High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial ovarian cancer (EOC), killing over 140,000 people annually. Morbidity and mortality are compounded by a lack of screening methods, and recurrence is common. Plasminogen-activator-inhibitor 1 (PAI-1, the protein product of SERPIN E1) is involved in hemostasis, extracellular matrix (ECM) remodeling, and tumor cell migration and invasion. Overexpression is associated with poor prognosis in EOC. Platelets significantly increase PAI-1 in cancer cells in vitro, and may contribute to the hematogenous metastasis of circulating tumor cells (CTCs). CTCs are viable tumor cells that intravasate and travel through the circulation–often aided by platelets - with the potential to form secondary metastases. Here, we provide evidence that PAI-1 is central to the platelet-cancer cell interactome, and plays a role in the metastatic cascade.Methods: SK-OV-3 cells where PAI-1 had been silenced, treated with healthy donor platelets, and treated with platelet-conditioned medium were used as an in vitro model of metastatic EOC. Gene expression analysis was performed using RNA-Seq data from untreated cells and cells treated with PAI-1 siRNA or negative control, each with and without platelets. Four cohorts of banked patient plasma samples (n = 239) were assayed for PAI-1 by ELISA. Treatment-naïve (TN) whole blood (WB) samples were evaluated for CTCs in conjunction with PAI-1 evaluation in matched plasma.Results and discussion: Significant phenotypic changes occurring when PAI-1 was silenced and when platelets were added to cells were reflected by RNA-seq data, with PAI-1 observed to be central to molecular mechanisms of EOC metastasis. Increased proliferation was observed in cells treated with platelets. Plasma PAI-1 significantly correlated with advanced disease in a TN cohort, and was significantly reduced in a neoadjuvant chemotherapy (NACT) cohort. PAI-1 demonstrated a trend towards significance in overall survival (OS) in the late-stage TN cohort, and correlation between PAI-1 and neutrophils in this cohort was significant. 72.7% (16/22) of TN patients with plasma PAI-1 levels higher than OS cutoff were CTC-positive. These data support a central role for PAI-1 in EOC metastasis, and highlight PAI-1’s potential as a biomarker, prognostic indicator, or gauge of treatment response in HGSOC.
Association between Parkinson's disease and the risk of adverse cardiovascular events: a systematic review and meta-analysis
Authors: Hu Yan , Xu Shanxia 
Published: December 2023

BackgroundThis review aims to examine the association of Parkinson's disease (PD) with the increased risk of cardiovascular events.MethodsPubMed, Embase, CENTRAL, and Scopus databases were electronically searched for papers published up to 5 May 2023. Studies reporting the association between PD and the subsequent risks of stroke, myocardial infarction (MI), and cardiovascular mortality were included.ResultsSixteen studies were included in this review. The clinical data of 101,712 PD patients were compared with that of the control group of 204,901 patients without PD in the included studies. Meta-analysis showed that PD patients had an increased risk of stroke compared with patients without PD (odds ratio (OR): 1.49; 95% confidence interval (CI): 1.30, 1.72; I2 = 76%). The pooled analysis demonstrated no significant increase in the risk of MI (OR: 1.16; 95% CI: 0.85, 1.59; I2 = 82%) and cardiovascular mortality (OR: 1.20; 95% CI: 0.93, 1.54; I2 = 65%) in PD patients. However, data from cohort studies indicated a possibility of higher risk of MI (OR: 1.36; 95% CI: 1.01, 1.84; I2 = 80%) and cardiovascular mortality (OR: 1.22; 95% CI: 1.00, 1.60; I2 = 62%) in patients with PD.ConclusionPatients with PD may have an increased risk of stroke as compared with the age- and gender-matched general population. While our results show that PD does not increase the overall risk of MI and cardiovascular mortality, analysis of cohort studies alone demonstrated that these risks may be higher in patients with PD. The current evidence is of very low quality. Further prospective cohort studies from different countries that would account for important cardiovascular risk factors are needed to improve the current evidence.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42023421924).
Performance investigation and mass transfer enhancement of a novel cone-type solar seawater still
Authors: Yang Jie , Chang Zehui , Zhang Xin , Zhu Guopeng 
Published: December 2023

There are some disadvantages in the operating process of the basin solar seawater still (BSSS), such as long mass transfer distance, large heat indolence, huge floor space, and poor bearing pressure ability. A novel cone-type solar seawater still (CTSSS) is presented to overcome the weaknesses of the BSSS in this study. The CTSSS has the characteristics of seawater liquid film evaporation, short mass transfer distance, the condensation sleeve is parallel to and above the evaporation sleeve, and the condensation area is larger than the evaporation area. In order to clarify the performance of the CTSSS, the influence mechanism of feed seawater mass flow rate, heating power and heating temperature on the fresh water yield of the CTSSS was analyzed, the method of enhancing the mass transfer of the binary mixed gas in the CTSSS was explored, and the law of heat and mass transfer of the binary mixed gas in the annular enclosed small space was investigated. The results indicated that the maximum fresh water yield of the CTSSS is 62.7 g/20 min at the feed seawater mass flow rate of 400 g/h when the input power is 200 W, which is 4.5% higher than that when the feed seawater mass flow rate is 300 g/h. The performance ratio (PR) of the CTSSS is increased as the heating power, the PR of the CTSSS is 0.65 when 180 W heating power is employed. The steady state fresh water yield of the CTSSS with mirror condensation sleeve at 85°C is 84.6 g/20 min, which is 12.1% higher than that with non-mirror condensation sleeve Compared with the CTSSS with non-mirror condensation sleeve, the value of proportions of radiative heat transfer in the total heat transfer of the CTSSS with mirror condensation sleeve decreased by 6.6%, and the value of proportions of evaporative heat transfer increased by 6.4%. This study would provide a reference for small-scale decentralized application of solar desalination in remote areas.
The trend of groundwater recharge in the secondary perched reaches of the Yellow River in the past 50 years
Authors: Zhang Min , Ping Jianhua , Mei Xuemei , Leng Wei , Li He , Zhao Jichang , Liu Jiaqi 
Published: December 2023

Precipitation infiltrates into the soil or river and then percolates downward through the deeper mineral soil to the groundwater. Understanding the interactions between surface water and groundwater in the river ecosystem is crucial for supporting decision-making in eco-construction and the efficient use of water resources. In our study, the secondary perched reach of the lower Yellow River was taken as the research area. The trend analysis and correlation relationship were evaluated using the M–K significance test and gray correlation; furthermore, the groundwater recharge was quantified by Darcy‘s law and the water balance method based on 50 years of hydrological data. The results showed that 1) from 1972 to 2020, the runoff and water level of the Huayuankou hydrological station and the Jiahetan hydrological station showed a significant downward trend. 2) The calculation of the gray correlation degree method shows that the groundwater level is mainly affected by the Yellow River. The river water and groundwater levels show a significant downward trend using the M–K significance test. 3) The unit width recharge values of the secondary perched river to the groundwater in the dry year were calculated to be 566.79 and 374.13 m3/m·d, using Darcy‘s law and the water balance method, respectively, indicating that the results of the two methods are basically the same. Our findings highlight the storage capacity of groundwater and can provide support for regulation and sustainable management of water resources in the ecosystem.
Multifactor assessment of ovarian cancer reveals immunologically interpretable molecular subtypes with distinct prognoses
Authors: Guo Yaping , Li Siyu , Li Chentan , Wang Li , Ning Wanshan 
Published: December 2023

BackgroundOvarian cancer (OC) is a highly heterogeneous and malignant gynecological cancer, thereby leading to poor clinical outcomes. The study aims to identify and characterize clinically relevant subtypes in OC and develop a diagnostic model that can precisely stratify OC patients, providing more diagnostic clues for OC patients to access focused therapeutic and preventative strategies.MethodsGene expression datasets of OC were retrieved from TCGA and GEO databases. To evaluate immune cell infiltration, the ESTIMATE algorithm was applied. A univariate Cox analysis and the two-sided log-rank test were used to screen OC risk factors. We adopted the ConsensusClusterPlus algorithm to determine OC subtypes. Enrichment analysis based on KEGG and GO was performed to determine enriched pathways of signature genes for each subtype. The machine learning algorithm, support vector machine (SVM) was used to select the feature gene and develop a diagnostic model. A ROC curve was depicted to evaluate the model performance.ResultsA total of 1,273 survival-related genes (SRGs) were firstly determined and used to clarify OC samples into different subtypes based on their different molecular pattern. SRGs were successfully stratified in OC patients into three robust subtypes, designated S-I (Immunoreactive and DNA Damage repair), S-II (Mixed), and S-III (Proliferative and Invasive). S-I had more favorable OS and DFS, whereas S-III had the worst prognosis and was enriched with OC patients at advanced stages. Meanwhile, comprehensive functional analysis highlighted differences in biological pathways: genes associated with immune function and DNA damage repair including CXCL9, CXCL10, CXCL11, APEX, APEX2, and RBX1 were enriched in S-I; S-II combined multiple gene signatures including genes associated with metabolism and transcription; and the gene signature of S-III was extensively involved in pathways reflecting malignancies, including many core kinases and transcription factors involved in cancer such as CDK6, ERBB2, JAK1, DAPK1, FOXO1, and RXRA. The SVM model showed superior diagnostic performance with AUC values of 0.922 and 0.901, respectively. Furthermore, a new dataset of the independent cohort could be automatically analyzed by this innovative pipeline and yield similar results.ConclusionThis study exploited an innovative approach to construct previously unexplored robust subtypes significantly related to different clinical and molecular features for OC and a diagnostic model using SVM to aid in clinical diagnosis and treatment. This investigation also illustrated the importance of targeting innate immune suppression together with DNA damage in OC, offering novel insights for further experimental exploration and clinical trial.