bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide characterization of the tomato UDP-glycosyltransferase gene family and functional identification of SlUDPGT52 in drought tolerance
Authors: Qiu Ling , Chen Xingyu , Hou Huifang , Fan Yuxuan , Wang Lulu , Zeng Haiyue , Chen Xueting , Ding Yin , Hu Xiaomeng , Yan Qingxia , Ma Huihui , Li Jinhua 
Published: November 2023

AbstractAbiotic stresses are major factors constraining the growth, development and productivity of tomato (Solanum lycopersicum), the most cultivated vegetable crop worldwide. Uridine diphosphate glycosyltransferases (UDPGTs or UGTs) are essential enzymes that utilize 5-uridine diphosphate as a glycosyl donor molecule to facilitate the catalysis of glycosylation reactions across diverse substrates, thereby playing a pivotal role in conferring abiotic stress tolerance. Currently, there is a limited understanding of the structure and functions of the UDPGT gene family in tomato. In this work, 106 members of the SlUDPGT gene family were identified through in silico analysis, besides, their protein sequence properties, phylogenetic relationships, gene structure, chromosomal distribution, cis-acting elements, tissue expression and hormone- and stress-induced expression were comprehensively investigated. The expression of representative SlUDPGTs under abiotic stress and exogenous hormone treatments, including salt, polyethylene glycol, methyl viologen, gibberellic acid, jasmonic acid, abscisic acid and brassinolide, was investigated through qRT‒PCR analysis. Numerous cis-acting elements linked to stress and hormone signaling were present in the promoter regions of SlUDPGTs. According to microarray data, most SlUDPGT genes were responsive to hormones and abiotic stresses, while certain SlUDPGTs were specifically differentially expressed under Botrytis cinerea and tomato spotted wilt virus infection. Additionally, diverse expression profiles of SlUDPGTs were observed in various tissues and developmental stages. Furthermore, CRISPR/Cas9-mediated knockout of SlUDPGT52 led to enhanced drought tolerance due to enhanced reactive oxygen species (ROS) scavenging. These findings lay the foundations for the future functional characterization of specific UDPGT gene family members, assisting the biotechnology-mediated improvement of tomato and other horticultural crops.
Nano-enabled crop resilience against pathogens: potential, mechanisms and strategies
Authors: Noman Muhammad , Ahmed Temoor , Wang Jiaoyu , Ijaz Munazza , Shahid Muhammad , Islam Mohammad Shafiqul , Azizullah  , Manzoor Irfan , Li Dayong , Song Fengming 
Published: November 2023

AbstractNanoparticles (NPs) have emerged as a revolutionary strategy in the field of agriculture, offering innovative solutions for enhancing plant health, disease management, and sustainable crop production. This review summarizes the multifaceted roles of NPs, synthesized chemically and biologically, in crop disease management, encompassing the NP modulation of plant immunity against pathogens, mechanisms of NP uptake, and potential applications in disease control. The integration of NPs as delivery vehicles for bioactive molecules, enabling targeted delivery of nutrients, hormones, RNA interference molecules, and chemical protectants for growth regulation and disease management, is also discussed in detail. The review also critically examines the safety and environmental considerations associated with the potential application of NPs in the agriculture sector, including environmental toxicity, fate, and risks. Future perspectives encompass precision agriculture, eco-friendly disease management, unraveling intricate plant-NP interactions, and the necessity for responsible innovation. At the nexus of nanotechnology and agriculture, this review underscores the transformative potential of NPs in revolutionizing plant health and crop disease management, while highlighting the importance of responsible application to ensure sustainable and resilient agricultural systems.
A longitudinal study of conversational remembering in WhatsApp group messages before, during, and after COVID-19 lockdown
Authors: Bietti Lucas M. , Mayor Eric 
Published: November 2023

Abstract
Conversational remembering entails that people engage in recalling past experiences, which may themselves have been shared. Conversational remembering comes with social benefits for the person telling the narrative and the one receiving it (e.g., developing and strengthening friendships, fostering entertainment, and consolidating group identity). COVID-19 lockdowns have significantly affected social interaction, including face-to-face interactions where conversational remembering occurs. The aim of this study was to explore how WhatsApp group messages supported conversational remembering in a large group of friends living in Buenos Aires where a complete lockdown was established between 19 March 2020 and 6 November 2020. To accomplish such aim, we conducted a mixed-methods longitudinal study. The data consisted of 32,810 WhatsApp group messages collected over a period of 700 consecutive days, from 13 April 2019 to 13 March 2021. Our study shows that WhatsApp group messages enabled group members to keep connected during the COVID-19 lockdown period. This occurred by remembering together situations, events, and actions associated with the group's identity. The use of WhatsApp group messages may have represented an adaptive collective behaviour in response to changes in global social norms.
Community and People in Catholic Thought, 1830–1870
Authors: Romani Roberto 
Published: November 2023

AbstractFar from being limited to denunciations of modernity, nineteenth-century Catholic thought had a programmatic and visionary side. This article deals with the models of community put forward by Lamennais inL'Avenir, Antonio Rosmini, Luigi Taparelli d'Azeglio, and Wilhelm Ketteler. These writers reimagined the foundations of public life against the claims of self-interested individualism and state omnipotence. Three theses in particular capture their vision of the future polity: 1) societies, which were not “mechanisms,” needed Catholicism as animating spirit; 2) political representation should be “organic”; and 3) whereas the liberal elites imposed their vested interests on the common people, the Catholic polity reflected their needs and beliefs. The four writers envisaged a community of the gentle and caring, which, like the family, was hierarchical, self-governed, local, and supportive. In contrast, it was argued that the people had no voice under liberalism because the elite's values were not the people's and because the political system was a mere arena for the clash of special interests. This was a communitarian and populist Catholicism, prizing self-government, denouncing parliamentary politics, and siding with “the people.”
Novel detection of Leishmania RNA virus-1 (LRV-1) in clinical isolates of Leishmania Viannia panamensis
Authors: Kariyawasam Ruwandi , Lau Rachel , Valencia Braulio M. , Llanos-Cuentas Alejandro , Boggild Andrea K. 
Published: November 2023

Abstract
American tegumentary leishmaniasis comprises a discrete set of clinical presentations endemic to Latin America. Leishmania RNA virus-1 (LRV-1) is a double-stranded RNA virus identified in 20–25% of the Leishmania Viannia braziliensis and L. V. guyanensis, however not in L. V. panamensis. This is the first report of LRV-1 in L. V. panamensis and its associations with clinical phenotypes of ATL. Unique surplus discard clinical isolates of L. V. panamensis were identified from the Public Health Ontario Laboratory (PHOL) and the Leishmania Clinic of the Instituto de Medicina Tropical ‘Alexander von Humboldt’ between 2012 and 2019 and screened for LRV-1 by real-time polymerase chain reaction. Patient isolates were stratified according to clinical phenotype. Of 30 patients with L. V. panamensis, 14 (47%) and 16 (53%) patients had severe and non-severe ATL, respectively. Five (36%) of 14 severe cases and 2 (12%) of 16 non-severe cases were positive for LRV-1, respectively. No differences in sex were observed for clinical phenotype and LRV-1 status. Although an association between LRV-1 status and clinical phenotype was not demonstrated, this is the first description of the novel detection of LRV-1 in L. V. panamensis, a species that has been documented predominantly in Central America.
An outbreak of Salmonella Typhimurium associated with the consumption of raw liver at an Eid al-Adha celebration in Wales (UK), July 2021
Authors: Adamson James P. , Sawyer Clare , Hobson Gemma , Clark Emily , Fina Laia , Orife Oghogho , Smith Robert , Williams Chris , Hughes Harriet , Jones Allyson , Swaysland Sarah , Somoye Oluwaseun , Phillips Ryan , Iqbal Junaid , Mohammed Israa , Karani George , Thomas Daniel Rhys 
Published: November 2023

Abstract
In July 2021, Public Health Wales received two notifications of salmonella gastroenteritis. Both cases has attended the same barbecue to celebrate Eid al–Adha, two days earlier. Additional cases attending the same barbecue were found and an outbreak investigation was initiated. The barbecue was attended by a North African community’s social network. On same day, smaller lunches were held in three homes in the social network. Many people attended both a lunch and the barbecue. Cases were defined as someone with an epidemiological link to the barbecue and/or lunches with diarrhoea and/or vomiting with date of onset following these events. We undertook a cohort study of 36 people attending the barbecue and/or lunch, and a nested case-control study using Firth logistic regression. A communication campaign, sensitive towards different cultural practices, was developed in collaboration with the affected community. Consumption of a traditional raw liver dish, ‘marrara’, at the barbecue was the likely vehicle for infection (Firth logistic regression, aOR: 49.99, 95%CI 1.71–1461.54, p = 0.02). Meat and offal came from two local butchers (same supplier) and samples yielded identical whole genome sequences as cases. Future outbreak investigations should be relevant to the community affected by considering dishes beyond those found in routine questionnaires.
All that flows across the ventricular septum are not ventricular septal defects
Authors: Mondal Sudipta , Raja Dinesh P. , Gopalakrishnan Arun 
Published: November 2023

AbstractCoronary cameral fistula is a rare congenital anomaly and clinical presentation depends on the location of the defect, degree of shunting, and associated complications. We present a case of coronary cameral fistula where segmental analysis by echocardiogram helped us to avoid misdiagnosis as a ventricular septal defect.
EMS Responses for Pediatric Behavioral Health Emergencies in the United States: A 4-Year Descriptive Evaluation
Authors: Boland Lori L. , Anderson Morgan K. , Powell Jonathan R. , Patock Michael T. , Panchal Ashish R. 
Published: November 2023

AbstractBackground:The occurrence of behavioral health emergencies (BHEs) in children is increasing in the United States, with patient presentations to Emergency Medical Services (EMS) behaving similarly. However, detailed evaluations of EMS encounters for pediatric BHEs at the national level have not been reported.Methods:This was a secondary analysis of a national convenience sample of EMS electronic patient care records (ePCRs) collected from January 1, 2018 through December 31, 2021. Inclusion criteria were all EMS activations documented as 9-1-1 responses involving patients < 18 years of age with a primary or secondary provider impression of a BHE. Patient demographics, incident characteristics, and clinical variables including administration of sedation medications, use of physical restraint, and transport status were examined overall and by calendar year.Results:A total of 1,079,406 pediatric EMS encounters were present in the dataset, of which 102,014 (9.5%) had behavioral health provider impressions. Just over one-half of BHEs occurred in females (56.2%), and 68.1% occurred in patients aged 14-17 years. Telecommunicators managing the 9-1-1 calls for these events reported non-BHE patient complaints in 34.7%. Patients were transported by EMS 68.9% of the time, while treatment and/or transport by EMS was refused in 12.5%. Prehospital clinicians administered sedation medications in 1.9% of encounters and applied physical restraints in 1.7%. Naloxone was administered for overdose rescue in 1.5% of encounters.Conclusion:Approximately one in ten pediatric EMS encounters occurring in the United States involve a BHE, and the majority of pediatric BHEs attended by EMS result in transport of the child. Use of sedation medications and physical restraints by prehospital clinicians in these events is rare. National EMS data from a variety of sources should continue to be examined to monitor trends in EMS encounters for BHEs in children.
Anisotropic Velocity Structure Beneath Shikoku, Japan: Insights From Receiver Function and Shear Wave Splitting Analyses
Authors: Ruan Yihuan , Ito Yoshihiro , Sawaki Yasunori 
Published: November 2023

AbstractA combination of receiver function (RF) analysis and shear wave splitting can reveal the anisotropic properties of the Earth's velocity structure. The RF profile exhibits harmonic patterns partially generated from the discontinuities of anisotropic media near the receiver. The anisotropic properties are determined using splitting parameters, which include the fast polarization direction (FPD) and split time. We utilized the seismograms recorded by stations on Shikoku Island, Japan. Also, we applied the Bayesian information criterion to control the spike count of each RF, which consists of a series of spikes generated by time‐domain iterative deconvolution. Anisotropic differences arose between northern and southern regions along the 30‐km iso‐depth line of the top surface of the Philippine Sea Plate. In the southern part of Shikoku Island, the FPDs are sub‐perpendicular to the plunge of the subducting slab, while in the northern part, they are sub‐parallel to the plunge of the slab. Our results indicate that anisotropic strengths are weaker in the tectonic‐tremor band in northwestern Shikoku and stronger in the northern part of central and eastern Shikoku around the no tectonic‐tremor area. These anisotropic variations may characterize Shikoku Island’s geological structure.
Effects of Pore Geometry and Saturation on the Behavior of Multiscale Waves in Tight Sandstone Layers
Authors: Ba Jing , Ma Rupeng , Carcione José M. , Shi Ying , Zhang Lin 
Published: November 2023

AbstractGeometric heterogeneities in tight reservoir rocks saturated with a fluid mixture may exhibit different scale distribution characteristics. Conventional models of rock physics based on poroelasticity, which usually consider single‐scale pore structure and fluid patches, are inadequate for describing elastic wave responses. A major challenge is to establish the relationship between the wave response at different spatial scales and frequencies. To address this problem, three sets of observational data over a wide frequency range were obtained from a tight oil reservoir in the Ordos Basin, China. Ultrasonic measurements were made on eight sandstone samples at partial oil‐water saturation at 0.55 MHz. Data from six borehole measurements and seismic profiles were acquired and analyzed at about 10 kHz and 30 Hz, respectively. Analysis of the cast thin sections shows that dissolution pores and microcracks generally develop, with fractal dimensions of the pores ranging from 2.45 to 2.67 for the samples with porosities between 5.1% and 10.2%. Compressional wave velocity and attenuation were estimated from the observed data. The results show that the velocity dispersion from seismic to ultrasonic frequencies is 10.02%, mostly occurring between sonic and ultrasonic frequencies. The attenuation is stronger at higher oil saturation. The relationships between velocity, attenuation, and wavelength were established and can be used for further forward modeling and seismic interpretation studies. A partial saturation model has been derived based on effective differential medium theory and a double double‐porosity model, assuming that the medium contains fractal cracks and fluid patches. The effects of scale and saturation on wave responses are prevalent. Modeling results consistent with observed data show that the radii of cracks and fluid patches range from 0.1 μm to 2.8 mm, affecting ultrasonic, acoustic, and seismic attenuation. The multiscale data and proposed model quantify the relationship between fracture and fluid distributions and attenuation and could be useful for upscaling to the reservoir scale. The study helps improve the understanding of seismic wave propagation in partially saturated rocks, which has potential applications in seismic exploration, hydrocarbon production in reservoirs, and CO2 sequestration in aquifers.
High‐Latitude, Indian Ocean, and Orbital Influences on Eastern African Hydroclimate Across the Plio‐Pleistocene Boundary
Authors: Mitsunaga Bryce A. , Lupien Rachel L. , Ouertani Samantha , Stubbs Brandon , Deino Alan L. , Kingston John D. , Stockhecke Mona , Brown Erik T. , Russell James M. 
Published: November 2023

AbstractTerrestrial‐marine dust fluxes, pedogenic carbonate δ13C values, and various paleovegetation proxies suggest that Africa experienced gradual cooling and drying across the Pliocene‐Pleistocene (Plio‐Pleistocene) boundary (2.58 million years ago [Ma]). However, the timing, magnitude, resolution, and relative influences of orbitally‐driven changes in high latitude glaciations and low latitude insolation differ by region and proxy. To disentangle these forcings and investigate equatorial eastern African climate across the Plio‐Pleistocene boundary, we generated a high‐resolution (∼3,000‐year) data set of compound‐specific n‐alkane leaf wax δ2H values—a robust proxy for atmospheric circulation and precipitation amount—from the HSPDP‐BTB13‐1A core, which spans a ∼3.3–2.6 Ma sequence in the Baringo‐Tugen Hills‐Barsemoi Basin of central Kenya. In combination with the physical sedimentology, our data indicate that precipitation varied strongly with orbital obliquity, not precession, during the late Pliocene, perhaps imparted by variations in the cross‐equatorial insolation gradient. We also observe a marked shift toward wetter conditions beginning ∼3 Ma that corresponds with global cooling, drying in western Australia, and a steepening of the west‐east zonal Indian Ocean (IO) sea surface temperature (SST) gradient. We propose that northward migration of the Subtropical Front reduced Agulhas current leakage, warming the western IO and causing changes in the IO zonal SST gradient at 3 Ma, a process that has been observed in the latest Pleistocene‐Holocene but not over longer timescales. Thus, the late Cenozoic moisture history of eastern Africa is driven by a complex mixture of low‐latitude insolation, the IO SST gradient, and teleconnections to distal high‐latitude cooling.
Geophysics‐Informed Hydrologic Modeling of a Mountain Headwater Catchment for Studying Hydrological Partitioning in the Critical Zone
Authors: Chen Hang , Niu Qifei , Mendieta Aida , Bradford John , McNamara James 
Published: November 2023

AbstractHydrologic modeling has been a useful approach for analyzing water partitioning in catchment systems. It will play an essential role in studying the responses of watersheds under projected climate changes. Numerous studies have shown it is critical to include subsurface heterogeneity in the hydrologic modeling to correctly simulate various water fluxes and processes in the hydrologic system. In this study, we test the idea of incorporating geophysics‐obtained subsurface critical zone (CZ) structures in the hydrologic modeling of a mountainous headwater catchment. The CZ structure is extracted from a three‐dimensional seismic velocity model developed from a series of two‐dimensional velocity sections inverted from seismic travel time measurements. Comparing different subsurface models shows that geophysics‐informed hydrologic modeling better fits the field observations, including streamflow discharge and soil moisture measurements. The results also show that this new hydrologic modeling approach could quantify many key hydrologic fluxes in the catchment, including streamflow, deep infiltration, and subsurface water storage. Estimations of these fluxes from numerical simulations generally have low uncertainties and are consistent with estimations from other methods. In particular, it is straightforward to calculate many hydraulic fluxes or states that may not be measured directly in the field or separated from field observations. Examples include quickflow/subsurface lateral flow, soil/rock moisture, and deep infiltration. Thus, this study provides a useful approach for studying the hydraulic fluxes and processes in the deep subsurface (e.g., weathered bedrock), which needs to be better represented in many earth system models.
Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival
Authors: Simhal Anish K. , Maclachlan Kylee H. , Elkin Rena , Zhu Jiening , Norton Larry , Deasy Joseph O. , Oh Jung Hun , Usmani Saad Z. , Tannenbaum Allen 
Published: November 2023

AbstractThe plasma cell cancer multiple myeloma (MM) varies significantly in genomic characteristics, response to therapy, and long-term prognosis. To investigate global interactions in MM, we combined a known protein interaction network with a large clinically annotated MM dataset. We hypothesized that an unbiased network analysis method based on large-scale similarities in gene expression, copy number aberration, and protein interactions may provide novel biological insights. Applying a novel measure of network robustness, Ollivier-Ricci Curvature, we examined patterns in the RNA-Seq gene expression and CNA data and how they relate to clinical outcomes. Hierarchical clustering using ORC differentiated high-risk subtypes with low progression free survival. Differential gene expression analysis defined 118 genes with significantly aberrant expression. These genes, while not previously associated with MM, were associated with DNA repair, apoptosis, and the immune system. Univariate analysis identified 8/118 to be prognostic genes; all associated with the immune system. A network topology analysis identified both hub and bridge genes which connect known genes of biological significance of MM. Taken together, gene interaction network analysis in MM uses a novel method of global assessment to demonstrate complex immune dysregulation associated with shorter survival.