bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten relevant questions for applying biodiversity offsetting in the Pantanal wetland
Authors: Lourival Reinaldo Francisco Ferreira , de Roque Fabio de Oliveira , Bolzan Fábio Padilha , Guerra Angélica , Nunes Alessandro Pacheco , Lacerda Ana Cristyna Reis , Nunes André Valle , Alves Amanda , Filho Antônio Conceição Paranhos , Ribeiro Danilo Bandini , Eaton Donald P. , Brito Elizângela Silva , Fischer Erich , Neto Francisco Valente , Porfirio Grasiela , Seixas Gláucia Helena Fernandes , Pinto João Onofre Pereira , Quintero Jose Manuel Ochoa , Sabino José , Sugai Larissa Sayuri Moreira , Garcia Leticia Couto , Matsumoto Marcelo H. , Silva Mariza , Almeida‐Gomes Mauricio , Stefanes Mauricio , Mills Morena , Pays Olivier , Renaud Pierre Cyril , Loyola Rafael Dias , Guariento Rafael Dettogni , Crouzeilles Renato , Chiaravalloti Rafael Morais , Morato Ronaldo Gonsalves , Santos Sandra Aparecida , Ikeda‐Castrillon Solange , Izzo Thiago , Semedo Thiago Borges Fernandes , Tomas Walfrido Moraes 
Published: February 2025

AbstractIn Brazil, biodiversity offsetting operates in an ad hoc manner while biodiversity equivalence has mainly been overlooked by public policies. Despite being mandatory since 1965s Forest Code (Law 4.771), we fail to have a robust offsetting framework. The revision of the forest code in 2012 (i.e., Native Vegetation Protection Law—NVPL—Law n° 12,651/2012), maintained the obligation for landowners to set aside a biome‐specific percentage of their native vegetation for preservation. Known as Legal Reserves, these set‐asides are a precondition for compliance with NVPL's regularization procedure called CAR (Rural Environmental Cadaster). Despite enthusiasm about biodiversity offsetting opportunities following the NVPL enactment in 2012, uncertainties around its implementation remains. Here, we formulated 10 questions that discuss and illustrate how offsetting can be applied to maintain wetland integrity, economic fairness and biodiversity conservation in the Pantanal and Upper Paraguay River basin (UPRB). The aim is to stimulate robust public policies and stimulate wetland offsetting research opportunities. We provided examples of implementation opportunities of the NVPL in integrating the floodplain and highland in Pantanal at UPRB, analyze spatial compliance deficits, and illustrate opportunities that require harmonized legislation and policies between Mato Grosso and Mato Grosso do Sul states in Brazil.
Validating Low‐Dose Iohexol as a Marker for Glomerular Filtration Rate by In Vitro and In Vivo Studies
Authors: Dong Qian , Chen Zhendong , Boland Jana , Dokos Charalambos , Hagos Yohannes , Kühne Annett , Taubert Max , Gründemann Dirk , Fuhr Uwe 
Published: February 2025

ABSTRACTClearance of an intravenous iohexol dose of 3235 mg is used to assess glomerular filtration rate (GFR), although systematic assessment of its pharmacokinetic (PK) properties is incomplete. The objectives of the present investigations were (i) to assess potential interactions of iohexol with important drug transporters, and (ii) whether a 259 mg dose could replace the current standard dose. In vitro, we evaluated whether iohexol inhibits or is transported by renal transporters (hOAT1/3, hOCT2, and hMATE1/2K) or other transporters (hOATP1B1/3, hOCT1, and hMDR1) using cell‐based and vesicle‐based systems. In vivo, we conducted a clinical trial with 12 volunteers with the administration of single intravenous doses of 3235 mg (“reference”) and 259 mg (“test”) using a changeover design. Plasma and urine samples were collected up to 24 h postdose. We assessed the dose linearity of iohexol pharmacokinetics using the standard bioequivalence approach and conducted a population PK analysis to characterize its profile. Our in vitro findings indicate that iohexol is neither a substrate nor a significant inhibitor of the transporters, suggesting it is unlikely to participate in transporter‐mediated drug–drug interactions in vivo. In the clinical trial, the test/reference ratio for plasma clearance, calculated as dose divided by the area under the plasma concentration–time curve, was 1.01 (90% confidence interval 0.968–1.05), confirming dose linearity. Population PK analysis further supported these results, showing no significant effect of dose on renal clearance and negligible nonrenal clearance of iohexol. Low‐dose iohexol is a suitable marker for precise GFR measurement, even when coadministered with other drugs.
Substance‐involved child‐to‐parent violence
Authors: Harries Travis , Mayshak Richelle , Skvarc David , Eckhardt Christopher , Benstead Michelle , Miller Peter , Curtis Ashlee 
Published: February 2025

AbstractIntroductionChild‐to‐parent violence (CPV) is associated with youth substance problems; however, CPV which is substance‐involved (SU‐CPV) is specifically excluded from the consensus definition of CPV and few studies have explored the familial context surrounding SU‐CPV. This study utilised the I3 model to explore associations between parental monitoring, parental intrusiveness, affective reactivity, concurrent reactive CPV and SU‐CPV in an Australian community sample of caregivers.MethodsA total of 119 caregivers experiencing abusive CPV (frequent and severe) completed an online survey reporting on incidence of CPV from 12 to 24‐year‐olds under their care, parenting behaviours, traits of the young person and their experience of SU‐CPV.ResultsPoor parental monitoring was positively associated with SU‐CPV, and this relationship was stronger at higher levels of affective reactivity in the young person. There were no significant three‐way interactions.Discussion and ConclusionsSU‐CPV may be most likely to occur where opportunity for child substance use is high, and risk of escalation is also high. These findings should be used to inform current CPV intervention, which may otherwise neglect youth substance use.
Reaching Distance Influences Perceptual Decisions
Authors: Assarioti Eleonora E. , van Beers Robert J. , Smeets Jeroen B. J. , van Wijk Bernadette C. M. 
Published: February 2025

ABSTRACTDecision making is an integral part of everyday life. Recently, there has been a growing interest in the potential influence of action on perceptual decisions, following ideas of embodied decision making. Studies examining decisions regarding the direction of noisy visual motion have found a bias towards the least effortful response option in experiments in which the differences in motor costs associated with alternative response actions were implicit, but not in an experiment in which these differences were made explicit. It remains unclear whether the biasing effect generalizes to other perceptual tasks than motion perception and whether consciously experiencing motor costs prevents such biases. To test the generalizability of effects across perceptual tasks, we used a within‐subjects design where 24 participants performed both a motion discrimination task and an orientation discrimination task. Motor costs were manipulated by presenting response buttons for the two alternative choices at different reaching distances. By varying distances randomly, we avoided implicit biases linked to specific decisions. Our findings revealed a bias towards closer response options in both tasks, indicating that explicit information of motor costs significantly impacts perceptual decisions beyond motion discrimination. Contrary to prevailing theories that consider the motor system as a mere effector of the decision, our study implies that the actions that are associated with the response options influence the decision process itself.
Brain Iron Alteration in Pediatric Tourette Syndrome: A Quantitative Susceptibility Mapping Study
Authors: Lin Liping , Ruan Zhibin , Li Yufen , Qiu Huaqiong , Deng Chengfen , Qian Long , Cui Wei , Tang Wen , Yang Zhiyun , Cheng Yanglei , Liang Yujian , Su Shu 
Published: February 2025

ABSTRACTBackgroundThe cortico‐striato‐thalamo‐cortical circuits play a crucial role in the pathogenesis of Tourette syndrome (TS). While iron deficiency has been reported in adult TS, the iron content in pediatric TS remains poorly understood. This study aims to quantitatively assess whole‐brain iron deposition in pediatric TS compared to typically developing (TD) children using quantitative susceptibility mapping (QSM).MethodsIn this prospective study, we recruited 50 children with a clinical diagnosis of TS and 50 age‐ and gender‐matched TD controls. Whole‐brain images were acquired using 3D T1 and multi‐echo gradient‐recalled echo sequences. QSM maps were generated using the STISuite toolbox. After normalizing the QSM maps to Montreal Neurological Institute space, voxel‐based analysis was applied to compare between‐group differences in iron content. Additionally, we evaluated the relationship between iron content and tic severity in TS children using the Pearson's correlation test.ResultsCompared to TD children, those with TS exhibited iron deficiency in the right anterior cingulum (pFDR < 0.001). Conversely, increased QSM values were observed in the bilateral putamen of TS children (pFDR < 0.001). Notably, QSM values in the left putamen showed a significant negative correlation with tic severity (p = 0.044).ConclusionsOur findings suggest that disturbed brain iron homeostasis in specific regions is associated with pediatric TS. These results reinforce the importance of the cortico‐striato‐thalamo‐cortical circuits in TS pathogenesis and highlight the potential role of iron dysregulation. Furthermore, our study demonstrates that QSM could serve as a valuable auxiliary biomarker for diagnosing and potentially monitoring pediatric TS.
Bilateral nontraumatic subcapsular renal haematoma (Wunderlich syndrome) in a Thoroughbred broodmare
Authors: Hannan M. , Verwilghen D. , Gibbons F. , Burden C. , Liechti R. , Forde O. , Meyer N. , Roati V. , Remaj B. , van Galen G. 
Published: February 2025

SummaryThis case report describes a Thoroughbred broodmare referred for colic and pyrexia. The mare had a history of repeated urinary tract infections, placentitis, abortion and endotoxaemia. A diagnosis of bilateral subcapsular renal haematoma was made by ultrasonography and standing laparoscopy and confirmed on post‐mortem. Neoplasia and an active clotting disorder were ruled out as a cause of the bleeding. However, histopathology revealed severe, diffuse, acute fibrinosuppurative tubulointerstitial nephritis with degeneration of vascular walls, suggesting that this has caused renal bleeding and development of subcapsular haematomas.
Biocultural Evolution and the Imagination: Outlining Scientific Perspectives for Theological Reflection
Authors: Lorrimar Victoria 
Published: February 2025

AbstractThe human imagination is studied widely across both the sciences and the humanities, yet there is a lack of conceptual clarity for interdisciplinary engagement. This article surveys a sample of recent scientific research on the imagination, focusing on creativity and storytelling, to demonstrate how an understanding of the biocultural evolutionary context may yield helpful insights for contemporary theological anthropology. Niko Tinbergen's levels of analysis (mechanism, function, phylogeny, and ontogeny) are used as a guiding framework to structure the scientific content. The final section sketches some of the recent trajectories in theological anthropology that are supported by a biocultural evolutionary perspective on the imagination, namely those that emphasise the hybridity of human being and resist human/non‐human binaries. This exercise in examining scientific perspectives for theological construction is reflected upon in the context of a broader science‐engaged theology methodology.
Teaching Writing in the Chinese Primary and Secondary School Contexts: An Analysis of the Discourses of Writing in L2 Curriculum Documents
Authors: Yu Shulin , Liu Simin 
Published: February 2025

ABSTRACTDespite the significance of second language (L2) writing curricula in guiding effective and successful teaching practices, limited studies have explored the underlying pedagogical philosophies and values in writing curricula in L2 school contexts. Utilizing the writing discourse framework, the current study assessed and analyzed L2 writing curriculum documents in primary and secondary schools in the Chinese Mainland, Hong Kong, and Macau. The findings revealed prevalent skills and social practices discourses, insufficient process and genre discourses, and minimum creativity and sociopolitical discourses in L2 writing curricula. Such findings, together with the observed curricular consistency and distinct curricular features across different regions, provide insights into curricular teaching philosophies and the development of L2 writing curricula and teaching approaches in L2 school contexts.
Evaluating the Free Speech Objection to Removing Tainted Political Symbols
Authors: Manninen Tuomas W. 
Published: February 2025

ABSTRACTIn recent years, several philosophers have argued that statues which are morally tainted ought to be removed from public display. One objection to this claim is the free speech objection: removing the statues constitutes a violation of free speech rights. This objection suffers from two flaws. First, it is rarely articulated to its fullest potential. Second, the free speech objection is largely dismissed by philosophers who support the statues' removal. In this article, I will aim to rectify this situation by providing three different formulations of the free speech objection, based, respectively, on First Amendment jurisprudence, on Mill's consequentialist defense of free speech, and on Susan Dwyer's non‐consequentialist defense of the same. After formulating the three versions of the objection, I will consider them against the alleged duty to remove tainted statues, and argue that even under the strongest formulation of the free speech objection, it does not amount to a defeater to the duty.
Evidence‐Based Decision Making in Psychological Research: A Network Meta‐Analysis
Authors: Çimen Fatmanur , Seçer İsmail 
Published: February 2025

ABSTRACTIntroductionNetwork meta‐analysis (NMA) was introduced in the 1990s as an extension of standard meta‐analysis. Since then, it has been utilized in various scientific fields, particularly in medicine, to evaluate the effectiveness of therapies/interventions/treatments applied for specific outcomes. In recent years, NMA, which offers a highly attractive methodology for researchers, clinicians and decision‐makers, has gained popularity as a form of evidence synthesis. Recognized as providing the ‘highest level of evidence’, NMA is also crucial in conducting research in psychology and psychiatry. With advancements in psychology and psychiatry, specific programmes or interventions have been developed and continue to be developed to address particular problem areas. Due to the variety of these treatment methods, there has not yet been a study focusing on the direct comparison of some treatments. Therefore, the aim of this article is to introduce the NMA method and highlight its potential in evidence‐based decision‐making, particularly in the field of psychopathology. By doing so, it is anticipated that the perspective of clinicians can be broadened in planning appropriate therapies for psychopathologies.MethodsThe article was written as a comprehensive review using certain keywords.ResultsConsequently, it becomes challenging for decision‐makers, clinicians, or researchers to determine the best treatments for a specific outcome. At this point, NMA offers the opportunity to analyze direct and indirect comparisons of various treatments applied in psychology within a single analysis, thus holding great potential for researchers and practitioners. Despite this potential, NMA has not received sufficient attention from researchers in this field.ConclusionIn conclusion, NMA holds significant potential for use in psychology, where many treatment options exist, and its use is encouraged among clinicians and researchers in the field.
Prognosis of Fragment Reattachment in Anterior Crown Fractures: A Retrospective Study
Authors: Sung Lisu , Ku Hyemin , Shin Yooseok , Swaid Salma , Kim Dohyun , Roh Byoung‐Duck 
Published: February 2025

ABSTRACTObjectiveAlthough several studies have compared fragment attachment with resin build‐ups in anterior crown fractures, none have specifically investigated the outcome of reattached fragments. This retrospective study aimed to evaluate long‐term outcomes of fragment reattachment in anterior crown fractures and determine the prognostic affecting their success.Materials and MethodsWe retrospectively analyzed clinical records of patients who underwent fragment reattachment for crown fractures in anterior teeth (maxillary and mandibular central and lateral incisors) between 2008 and 2023. All procedures were performed by experienced professors and residents following a standardized protocol. Kaplan–Meier survival curves and Cox proportional hazards regression analyses were performed to evaluate fragment retention outcomes and identify potential prognostic factors.ResultsAmong 75 anterior crown fractures, the estimated fragment retention rates were 83.7% at 2 years, 75.2% at 5 years, and 56.4% at 10 years. Multivariate Cox regression analyses identified patient age and extent of crown fracture as significant factors affecting outcomes. The 5‐year estimated fragment retention rates were 82.8% and 67.0% for uncomplicated and complicated crown fractures, respectively.ConclusionsFragment reattachment remains a viable treatment option for anterior crown fractures. Treatment success decreased with patient age, and complicated crown fractures demonstrated lower retention rates than uncomplicated ones.Clinical SignificanceFragment reattachment can provide predictable outcomes in anterior crown fractures when cases are carefully selected, particularly considering the patient's age and the type of crown fracture.
Effect of Massage and Touch on Agitation in Dementia: A Meta‐Analysis
Authors: Liu Xiaotong , Zang Lili , Lu Qiuying , Zhang Yue , Meng Qinghui 
Published: February 2025

ABSTRACTAims and ObjectivesTo systematically assess the effects of massage and touch on agitation in patients with dementia and to determine the optimal intervention design.BackgroundAgitated behaviour is the most common behavioural symptom in patients with dementia and can seriously affect the health status and quality of life of individuals with dementia and their caregivers. Massage and touch have been widely used as a non‐pharmacological intervention to address the behavioural issues of dementia. However, current research findings on the effects of massage and touch on agitation in people with dementia are inconsistent.DesignA meta‐analysis of randomised controlled trials.MethodsThis meta‐analysis complied with PRISMA guidelines, and relevant literature up to January 2024 was systematically retrieved from PubMed, Embase, Web of Science, the Clinical Trials Registry, Cochrane Library and four Chinese databases. Statistical evaluations were performed utilising Review Manager 5.4, and the included studies' bias risks were assessed with the Cochrane Collaboration tool.ResultsSeventeen randomised controlled trials involving 980 patients with dementia were included. The results of the meta‐analysis showed that massage and touch could ameliorate agitation and behaviour problems in dementia. Subgroup analyses based on massage type showed that hand, head and foot massage significantly improved agitation. Massage and touch for ≤ 4 weeks were more effective in reducing agitated behaviour than those for > 4 weeks. Furthermore, subgroup analysis revealed that massages and touch were more effective for individuals with less severe dementia.ConclusionsMassage and touch in the short term can effectively improve agitation in dementia patients, while hand, head and foot massage can effectively reduce agitation. Thus, clinical nursing staff and caregivers of individuals should be actively helped to apply massage and touch to their patients. However, more studies are needed to validate our results before we can give a more definitive recommendation.Relevance to Clinical PracticeThis study suggests that massage and touch can be used as complementary treatments for agitation in people with dementia and encourages nursing staff and caregivers to apply massage and touch to better cope with the agitated behaviour of older adults with dementia.Patient or Public ContributionNo patient or public contribution.Trial RegistrationPROSPERO registration number: CRD42024507133
Factors Associated With Silent Brain Infarcts After Middle Cerebral Artery Stenting or Balloon Angioplasty
Authors: Lee Kyubong , Song Jeong Yoon , Oh Hyunsun , Kim Taewoo , Chang Jun Young , Kang Dong‐Wha , Kwon Sun U. , Hwang Seon Moon , Choi Joon Ho , Kwon Boseong , Song Yunsun , Lee Deok Hee , Kim Bum Joon 
Published: February 2025

ABSTRACTBackground and PurposeSilent brain infarcts (SBIs), which manifest as dot‐like lesions on diffusion‐weighted imaging (DWI) after endovascular procedures, are associated with an increased risk of stroke, dementia, and cognitive decline. We aimed to identify the factors associated with SBIs following middle cerebral artery (MCA) stenting or balloon angioplasty.MethodsWe retrospectively reviewed patients who underwent MCA stenting or balloon angioplasty, including those with symptomatic, atherosclerotic MCA stenosis of ≥50%. DWI scans were conducted before and after the procedure, and newly detected DWI lesions were classified as SBIs. We investigated the factors associated with the development of SBIs, and for patients with SBIs, we conducted a detailed analysis based on lesion location (cortex and perforator territory vs. cortex only vs. perforator territory only).ResultsAmong 120 patients, 64 (53.3%) exhibited SBIs postprocedure. Factors significantly associated with SBIs included smaller stenosis diameter (odd ratio [95% confidence interval] = 0.03 [0.002–0.35], p = 0.006), longer stenosis length (1.24 [1.02–1.51], p = 0.033), higher MCA tortuosity (1.20 [1.07–1.34], p = 0.002), and diffuse involvement of MCA stenosis (3.99 [1.17–13.62], p = 0.027). Among the patients who exhibited SBIs, D‐dimer (p = 0.002), C‐reactive protein (p = 0.026), and hemoglobin A1c (p = 0.025) differed according to detailed mechanism.ConclusionsStenosis diameter, stenosis length, and MCA tortuosity were significantly associated with the development of SBIs following MCA stenting.
Introduction to the Thematic Issue
Authors: Babel Anna M. , Campbell‐Kibler Kathryn , McGowan Kevin B. 
Published: February 2025

ABSTRACTThe topics of awareness and control have been investigated for decades in sociolinguistics, but they have been approached in different ways, both theoretically and methodologically, in different corners of the subdiscipline. This has resulted in confusing and sometimes contradictory terminology, as well as divergent theoretical perspectives on what, exactly, is meant by these terms. As our understanding of the relationships between various social and cognitive systems has become more detailed and sophisticated, it has become increasingly urgent to untangle the overlapping and at times contradictory ways of understanding these concepts. For this reason, this Thematic Series responds to a need for further and more coherent development of the concept of awareness ‐ and for coordination between different subfields of (socio)linguistics as we do so.