bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of radioactive iodine treatment for differentiated thyroid cancer on male gonadal function: a meta-analysis
Authors: Cai Yanling , Yang Yan , Pang Xiao , Li Suping 
Published: October 2023

Purpose
The aim was to investigate the effect of radioactive iodine (RAI) treatment for differentiated thyroid cancer (DTC) on male gonadal function.

Methods
PubMed, Embase, Web of Science, OVID, Scopus, and Wanfang databases were searched up to June 10, 2022, to identify published studies related to RAI and male gonadal function. ReviewManager version 5.4.1 software was used to calculate mean differences (MDs) with 95% CIs.

Results
Initially, 1958 articles were retrieved from the databases, and 6 articles were included in the quantitative analysis. The meta-analysis results showed that follicle-stimulating hormone (FSH) increased when the follow-up duration was ≥12 months after RAI, but the difference was not statistically significant (MD = −2.64, 95% CI = (−5.61, 0.33), P = 0.08). But the results of the subgroup analysis showed that when the follow-up time was ≤6 months, FSH levels were significantly higher after RAI (MD = −7.65, 95% CI = (−13.95, −1.34), P = 0.02). The level of inhibin B was significantly lower at ≥12 months and ≤6 months after RAI (MD = 66.38, 95% CI = (8.39, 124.37), P = 0.02) and (MD = 116.27, 95% CI = (43.56, 188.98), P = 0.002). Additionally, luteinizing hormone (LH) and testosterone have similar results – that is, LH and testosterone levels were higher after RAI, but the difference was not statistically significant (MD = –0.87, 95% CI = (−2.04, 0.30), P = 0.15) and (MD = −1.69, 95% CI (−7.29, 3.90), P = 0.55).

Conclusions
Male gonadal function may be temporarily impaired within 6 months after RAI but may return to normal levels afterward.
Consequences of a cesarean section on the neonatal gut microbiome and future outcomes: a qualitative analysis of the literature
Authors: Buffington Paige , Sebghati Alexia M , Stewart Kasey B , Lawson Samantha , Karaduta Oleg 
Published: October 2023

Objective
This study aims to evaluate the impact of cesarean section delivery on the neonatal intestinal microflora compared to vaginal deliveries.

Design
A mini-review.

Methods
A comprehensive search strategy was implemented, primarily using PubMed, to identify relevant studies published in English within the past 10 years. Selected studies were appraised by three independent reviewers using JBI critical appraisal and data extraction forms. Four articles were included in the analysis, encompassing systematic reviews and a retrospective cohort study. Primary and secondary outcome data were combined across these studies.

Results
Selected studies revealed consistent trends in bacterial colonization differences between cesarean and vaginal deliveries. Vaginally delivered infants exhibited higher populations of beneficial bacteria such as Bifidobacterium, Lactobacillus, and Bacteroides. Cesarean-delivered infants, on the other hand, showed greater colonization of Enterococcus, Klebsiella, Clostridium, Staphylococcus, Streptococcus, and Corynebacterium. Statistically significant differences were observed in two studies. All articles explored the potential health implications of these microbiome differences, with associations found between cesarean deliveries and various health outcomes.

Conclusion
This review demonstrates that cesarean section delivery influences the composition of the neonatal gut microbiota. The presence of certain bacterial species more prevalent in vaginally delivered infants, such as Bifidobacterium, is associated with improved infant health, while species found in cesarean-delivered infants, such as Clostridium, increase the risk of certain infections. Recognizing the increased health risks for cesarean-born infants enables clinicians to implement early screening, treatment, or prevention strategies, potentially reducing future morbidity and mortality.
A Rare Sigmoid-Colon Schwannoma in a Premenopausal Woman: A Case Report
Authors: Selntigia Aikaterini , Neri Benedetto , Russo Consuelo , Martire Francesco Giuseppe , Soreca Giorgia , Biasutto Dario , Di Matteo Francesco Maria , Exacoustos Caterina 
Published: October 2023

Background. Schwannomas of the gastrointestinal tract are a rare type of spindle cell tumor of peripheral nerve. Commonly, schwannomas are discovered incidentally, as they are usually asymptomatic.Case. 46-year-old female patient, suffering from secondary amenorrhea and nonspecific intermittent pelvic pain associated with constipation. During gynecological visit an ultrasonographic systematic transvaginal examination was performed. At the sigmoid-rectal level an intraluminal solid mass was described and an urgent colonoscopy was prescribed. Endoscopic submucosal dissection was performed with en-bloc resection. On immunohistochemical analysis, S100 was strongly positive in tumor cells. Finally, a benign schwannoma of the sigmoid colon was diagnosed.Conclusion. Our case highlights the importance of an adequate transvaginal pelvic examination with the evaluation of all pelvic organs. It could be challenging to make diagnosis in an early stage on asymptomatic patients.
Post-COVID-19 Syndrome and Related Dysautonomia: Reduced Quality of Life, Increased Anxiety and Manifestation of Depressive Symptoms: Evidence from Greece
Authors: Galanis Petros , Katsiroumpa Aglaia , Vraka Irene , Kosiara Katerina , Siskou Olga , Konstantakopoulou Olympia , Katsoulas Theodoros , Gallos Parisis , Kaitelidou Daphne 
Published: October 2023

Background: Post-COVID-19 syndrome affects a significant number of SARS-CoV-2 infected individuals, even in asymptomatic cases causing several neurological and neuropsychiatric symptoms and signs.Materials and Methods: An online cross-sectional study with a convenience sample was conducted in Greece from November 2022 to January 2023. We measured the demographic and clinical characteristics of patients with post-COVID-19 dysautonomia in terms of the quality of life with the EQ-5D-3L, and anxiety and depressive symptoms by employing Patient Health Questionnaire-4.Results: The study population included 122 patients with post-COVID-19 syndrome. One out of four patients (27.8%) manifested post-COVID-19 dysautonomia, while the mean duration of COVID-19 symptoms was 11.6 months. Anxiety and depressive symptoms were worse after the post-COVID-19 syndrome (p<0.001 in both cases). A statistically significant reduction in quality of life was observed among patients after the post-COVID-19 syndrome (p<0.001 for both EQ-5D-3L index value and EQ-5D-3L VAS). Post-COVID-19 dysautonomia increased depression symptoms after developing the post-COVID-19 syndrome (p=0.02). We found a negative relationship between the duration of COVID-19 symptoms and the quality of life (p<0.001). Moreover, our results showed that depressive symptoms were more common among females after the post-COVID-19 syndrome (p=0.01). Also, the quality of life was lower among females than males (p=0.004 for EQ-5D-3L index value, and p=0.007 for EQ-5D-3L VAS).Conclusions: Our results suggest that post-COVID-19 syndrome causes a tremendous impact on the patients’ quality of life and mental health. In addition, we found that the groups most psychologically affected were patients with post-COVID-19 dysautonomia, females, and patients with a longer duration of symptoms. Policy makers should assign priority rights to vulnerable groups in future psychiatric planning. Policy measures should focus on the mental health of post-COVID-19 patients who seem to be particularly vulnerable.
Tuberculosis and Sudden Death in Lithuania
Authors: Zarembaitė Gintarė , Žiūkaitė Gabrielė , Chmieliauskas Sigitas , Vasiljevaitė Diana , Laima Sigitas , Stasiūnienė Jurgita 
Published: October 2023

Background: Tuberculosis is one of the most common infectious diseases in the world. 10.6 million people fell ill in 2021 and 1.6 million died from the disease. Lithuania has the third-highest tuberculosis incidence rate per 100,000 and the second-highest mortality rate per 100,000 in EU/EEA countries. During 2015–2021 years, there were 799 deaths of pulmonary tuberculosis in Lithuania. However, the presence of pulmonary tuberculosis is often unknown before death and is only revealed during autopsy. The aim of the study is to review current literature on this topic and present statistical analysis on evaluated socioeconomical, epidemiological indicators, as well as autopsy findings that may suggest pulmonary tuberculosis infection.Materials and methods: This research was designed as a retrospective study focusing on full forensic pathology autopsies between 2015 and 2021. Of these, 100 cases were randomly selected where the cause of death was tuberculosis diagnosed during post-mortem examination and compared to a control group consisting of 415 cases of sudden death.Results: The study revealed that out of 100 pulmonary tuberculosis cases, 90% were male with the mean age of 53.48 ± 11.12 years old. In the case of sudden death where tuberculosis was found, a significant portion of the sample (91%) was not followed up at any medical institution. Regarding socioeconomic factors, a moderate negative correlation between Lithuania’s gross domestic product and tuberculosis distribution was observed, as well as a weak negative correlation between alcohol consumption (l per capita) in the general population and tuberculosis distribution. The lung weight of the pulmonary tuberculosis group was statistically significantly higher than that of the control group.Conclusions: Tuberculosis remains a major problem in Lithuania and the combination of socioeconomic indicators determines the prevalence of tuberculosis in the country. In cases of sudden death, autopsy helps to identify tuberculosis cases that have not been clinically detected and ensures tuberculosis monitoring. Therefore, the person who performs autopsy remains at high risk of contracting tuberculosis. Furthermore, extreme caution is advised if higher lung weight or hardenings are seen during autopsy because of the possibility of tuberculosis.
Utility of High-Resolution Ultrasonography in the Evaluation of Posterior Segment Ocular Lesions Using Sensitivity and Specificity
Authors: Boruah Deb K. , Vishwakarma Daisy , Gogoi Pallavi , Lal Navneet R , Deuri Arup 
Published: October 2023

Background: High-resolution Ultrasound (USG) provides good anatomical details of the ocular posterior segment and depicts the various pathological conditions affecting the ocular posterior segment, which helps ophthalmologists for choosing the best treatment options. This study aims to evaluate the utility of High-resolution Ultrasonography in the Evaluation of Posterior Segment Ocular lesions by using Sensitivity and Specificity.Materials and Methods: A hospital-based retrospective study enrolled 81 patients in a tertiary care hospital. Clinical and ophthalmological examinations were performed followed by USG of the orbits. B-mode USG was done with a 7.5–13 MHz linear probe. The final diagnosis was made by correlating the USG findings with clinical and ophthalmological examinations.Statistical analysis: Sensitivity, specificity, the positive predictive value, the negative predictive value, and the accuracy of B-scan USG were compared with the ophthalmological findings by using the Chi-square test.Results: Of 81 patients (n=48 males and n=33 females) with a mean age of 38.98 ± 16.48 [SD] years, posterior segment ocular lesions in association with cataracts were found in 27 (33.3%) patients, whereas 14 (51.9%) patients had posterior vitreous detachment (PVD), 10 (37%) patients had retinal detachment (RD), and 1 (3.7%) patient had choroidal detachment (CD). Posterior segment ocular pathologies were found in 17 (21%) patients with blunt ocular injuries, whereas 8 (47.1%) patients had PVD, 4 (23.5%) patients had RD and 4 (23.5%) patients had CD. The ocular USG had a sensitivity of 87.32%, specificity of 80%, and accuracy of 86.42% with a statistically significant difference between the USG findings and the Ophthalmology diagnosis of the posterior segment ocular abnormalities of a p-value of 0.0005.Conclusion: High-resolution ultrasound is one of the best and an easily available imaging modality for the evaluation of posterior segment ocular pathologies, especially in the presence of opaque ocular media.
Homoiōsis Theōi: Plato’s Ultimate Educational Aim
Authors: Itao Alexis Deodato S. 
Published: October 2023

Many academics and researchers who publish scholarly articles on Plato’s philosophy of education claim that the ultimate educational goal for Plato is simply the acquisition of virtues. While such a claim may not be entirely incorrect, it is nevertheless substantially wanting; for although the acquisition of virtue is no doubt paramount, for Plato it primarily serves as a means to another end. In this paper, I aim to show that, for Plato, the final summit of all educational enterprise is not really to become virtuous but rather to attain the state of becoming like God, and that is, homoiōsis theōi.
Dotriacontal Number System in Computer and Error Detection
Authors: Islam Md. Jahurul , Sarker M. Mesbahuddin , Taher Taslim 
Published: October 2023

n this this paper for the first time, we have formulated the dotriacontal number system using existing number systems like binary, and hexadecimal numbers. The dotriacontal number is one with a base of 32, containing 32 single-character digits or symbols. Each symbol contains five binary digits. This number system can be used in computers for reducing memory consumption and for memory specification. Generally, the computer memory addresses are displayed in five hexadecimal integers. If the computer memory addresses can be showed in four dotriacontal integers rather of five hexadecimal integers, the memory consumption will be reduced. It also can be used to increase the number of MAC addresses, IPv4 and IPv6 addresses. MAC (Media Access Control) address can be constructed as six deckles or 12 integers of the dotriacontal numbers instead of six octet hexadecimal digits. The IPv4 address can be defined in 8 integers of dotriacontal number that is 240 that is 1099511627776 address, and also the IPv6 address can be designed in 32 digits of the dotriacontal number that is 2160 or 1.46150164E48 addresses. The dotriacontal number system can be effective to detect error message using the checksum method. Typically, the checksum method is used by a binary or hexadecimal number system but the checksum method can be easily applied in the dotriacontal number system to detect error messages. The proposed work of this paper will be implemented if the dotriacontal code is executed and the memory specification is defined as a 10 bits deckle system instead of 8 bits byte.
ERRATUM: THE EFFECT OF WAGE ON PRIVATE SECURITY OFFICERS JOB SATISFACTION AND INTENTION TO QUIT: AN EMPIRICAL STUDY IN TURKEY
Authors: Demirci Uğur , Ergen Banu 
Published: October 2023

Düzeltme: Dergimizde yayınlanmış olan “The Effect of Wage on Private Security Officers Job Satisfaction and Intention to Quit: An Empirical Study in Turkey. Elektronik Sosyal Bilimler Dergisi, 19(75), 1314-1334. https://doi.org/10.17755/esosder.616419” referanslı makale, “Demirci, U. (2019). İş Doyumu ile İşten Ayrılma Niyeti İlişkisine İstihdam Şekillerinin Etkisi. Uluslararası Sosyal Araştırmalar Dergisi, 12(62), 1246-1258. DOI:10.17719/jisr.2019.3134” referanslı makale verisi kullanılarak yazılmış ancak sehven dipnot verilmesi unutulmuştur. Yapılan bu hatadan dolayı yazarlar, okuyuculardan özür diler.Bu makalenin ilk hali 01-07-2020 tarihinde yayınlandı. https://dergipark.org.tr/tr/pub/esosder/issue/53427/616419
DÜZELTME: ÖĞRETMEN ADAYLARININ SOSYAL MEDYA ORTAMLARINI KULLANMA DURUMLARINA GÖRE ÇOK KÜLTÜRLÜ EĞİTİME İLİŞKİN GÖRÜŞLERİ: TÜRKİYE ÖRNEĞİ
Authors: Hark Söylemez Nesrin , Oral Behçet 
Published: October 2023

Dergimizin 2018 yılı 17.Cilt 68. Sayısında yayımlanan “Öğretmen Adaylarının Sosyal Medya Ortamlarını Kullanma Durumlarına Göre Çok Kültürlü Eğitime İlişkin Görüşleri: Türkiye Örneği” başlıklı makalede “Bu araştırma ikinci yazarın danışmanlığında, birinci yazarın “Öğretmen adaylarının sosyal medya kullanma durumlarına göre çokkültürlü eğitime ilişkin görüşleri" başlıklı doktora tezinin bir bölümüne dayalı olarak hazırlanmıştır." ifadesi yazarlar tarafından makalede dipnot olarak belirtilmiş olmasına rağmen makale yayınlanırken dergimiz tarafından bu dipnot sehven eksik verilmiştir. Makale, ikinci yazarın danışmanlığında, birinci yazarın “Öğretmen adaylarının sosyal medya kullanma durumlarına göre çokkültürlü eğitime ilişkin görüşleri" başlıklı doktora tezinin bir bölümüne dayalı olarak hazırlanmıştır.Bu makalenin ilk hali 24-10-2018 tarihinde yayınlandı. https://dergipark.org.tr/tr/pub/esosder/issue/39008/426803
Andrographolide Reverses Doxorubicin Resistance in Human Breast Cancer Stem Cells by Regulating Apoptotic Gene Expressions
Authors: Wanandi Septelia Inawati , Syahrani Resda Akhra , Suraduhita Ayu , Yunita Elvira , Louisa Melva 
Published: October 2023

BACKGROUND: Breast cancer stem cells (BCSCs) have been identified as playing a crucial role in therapeutic resistance. This resistance can be attributed to the anti-apoptotic protein survivin and the antioxidant MnSOD high expression. To overcome the resistance to doxorubicin (DOX), this study proposed the utilization of andrographolide (ANDRO), the primary bioactive compound in Andrographis paniculata leaves. The objective was to examine the role of andrographolide in regulating survivin, caspase-9, and caspase-3 gene expressions to reverse doxorubicin resistance in human BCSCs.METHODS: BCSCs were exposed to 0.1 µM DOX every two days or 50 µM rotenone (ROT) for 6 hours, subsequently supplemented with 0.3 mM ANDRO. Superoxide and peroxide levels were measured using DHE and DCFH-DA assay. The MnSOD, survivin, caspase-9, and caspase-3 mRNA expression levels were analyzed using qRT-PCR. Protein expressions were evaluated using Western blotting assay. MnSOD activity was determined using xanthine oxidase inhibition assay. The apoptotic cells were determined using Annexin-V/PI staining.RESULTS: This study indicated that the cytotoxic mechanisms of DOX, similar to ROT, in BCSCs were attributed to oxidative stress, as evidenced by an elevation in superoxide rather than peroxide levels, accompanied by a decrease in MnSOD activity. This study also highlighted that ANDRO reversed DOX resistance in BCSCs subjected to repeated DOX treatment by downregulating survivin and upregulating caspase-9 and caspase-3 mRNA expressions, thereby activating the intrinsic apoptotic pathway.CONCLUSION: This study provides insights into the role of ANDRO in modulating the expression of apoptotic genes, such as survivin, caspase-9, and caspase-3, to overcome DOX resistance in BCSCs.KEYWORDS: breast cancer, breast cancer stem cell, andrographolide, doxorubicin, oxidative stress, apoptosis
Da estética do tempo mínimo à poética da pandemia máxima
Authors: Martins José Endoença 
Published: October 2023

O ensaio discute as relações entre a produção poética e a experiência pandêmica. Estabelece o movimento identitário do narrador poético entre três modalidades de produção poética. Trata-se de triangulação artística que se envidencia entre Poema Minuto, Diet Poesia e Minimalismus Pandemicus. Para a caracterização do deslocamento intervérsico a tríplice produção artística, vale-se dos conceitos de “celebração móvel” de Hall (2006), das noções de dupla vocalidade da Signifyin(g) e da tripla dimensão de Exu e Iorubás, segundo Gates (1988), além da ideia de política da conversão de West (1994). O ensaio sugere recorrer a uma ética do amor que, segundo West, teria a capacidade de estabelecer uma epistemologia poética com vistas a proteger a terra e fazer um mundo melhor.
mt-tRNAs in the polymerase gamma mutant heart
Authors: Bayazit M. Bilal , Francois Ashley , McGrail Erin , Accornero Federica , Stratton Matthew S. 
Published: October 2023

Introduction: Mice harboring a D257A mutation in the proofreading domain of the mitochondrial DNA polymerase, Polymerase Gamma (POLG), experience severe metabolic dysfunction and display hallmarks of accelerated aging. We previously reported a mitochondrial unfolded protein response (UPTmt) - like (UPRmt-like) gene and protein expression pattern in the right ventricular tissue of POLG mutant mice.
Aim: We sought to determine if POLG mutation altered the expression of genes encoded by the mitochondria in a way that might also reduce proteotoxic stress.
Methods and Results: The expression of genes encoded by the mitochondrial DNA was interrogated via RNA-seq and northern blot analysis. A striking, location-dependent effect was seen in the expression of mitochondrial-encoded tRNAs in the POLG mutant as assayed by RNA-seq. These expression changes were negatively correlated with the tRNA partner amino acid’s amyloidogenic potential. Direct measurement by northern blot was conducted on candidate mt-tRNAs identified from the RNA-seq. This analysis confirmed reduced expression of MT-TY in the POLG mutant but failed to show increased expression of MT-TP, which was dramatically increased in the RNA-seq data.
Conclusion: We conclude that reduced expression of amyloid-associated mt-tRNAs is another indication of adaptive response to severe mitochondrial dysfunction in the POLG mutant. Incongruence between RNA-seq and northern blot measurement of MT-TP expression points towards the existence of mt-tRNA post-transcriptional modification regulation in the POLG mutant that alters either polyA capture or cDNA synthesis in RNA-seq library generation. Together, these data suggest that 1) evolution has distributed mt-tRNAs across the circular mitochondrial genome to allow chromosomal location-dependent mt-tRNA regulation (either by expression or PTM) and 2) this regulation is cognizant of the tRNA partner amino acid’s amyloidogenic properties.
Exploring Pedagogical Inadequacies in Current Teaching Practices in ESL Classroom at College Level: The Students’ perspective
Authors: Malik Amir Hafeez , Ramzan Fozia , Parveen Shahida , Rashid Abdul 
Published: October 2023

English language teaching and learning remain the focus of the academic system as English is a compulsory subject for all learners at college level. The success and smoothness of English language pedagogy depends largely on the active role of ELT teachers simply because of their dominant role inside classrooms. This paper presents a comprehensive view of pedagogical inadequacies in ESL classrooms at the college level in Punjab, Pakistan. This study is quantitative and the data has been collected through a survey questionnaire. The questionnaire was distributed to 250 students of public and private colleges of district Multan. Out of 250 students, 220 students responded questionnaire. The findings of the study proved that we are practicing inadequate pedagogical methods which are the root cause of learners’ dissatisfaction and poor quality of education. Quality teaching always remains a dream without enriching the teaching skills of the teachers that is only possible by removing the inadequacies in pedagogy. A revision of our pedagogical practices is suggested in the light of the analyzed data and drawn conclusion of the present study.