bluuebunny/crossref_metadata_2025_split huggingface dataset:
Literature, Feminism, and Activism in Rojhelat and the Diaspora
Authors: Hamelink Wendelmoet , Sophie Essmat 
Published: December 2023

Abstract
In this conversation, Essmat Sophie (author of the novel and animation film Dancing Amid Fire, Rising Above Ruins), talks with Wendelmoet Hamelink (researcher on gender, migration, activism, and conflict at the University of Oslo), about her interest in literature, about the creation of her novel and film, and about feminist life in the Diaspora. We discuss the fragmented lives of people who left Iran and can never return, and the history of the city Sine/Sanandaj. The conversation shows the complexity of Kurdish Iranian women’s triple struggle to escape political oppression, state violence, male dominance, as well as enduring a life of exile and marginalization. Essmat remembers the literature gatherings she attended in Sine, where women writers made a deep impact on her life as a young woman. Arguably, activist lives can be found in unexpected places and through creative strategies developed by women on the margins.
Afterword
Authors: Dirik Dilar 
Published: December 2023

Abstract
In recent years, the portrayal of queer/LGBTQI+ existence as a foreign imposition, backed by western cultural hegemony, has gained currency in the Middle East and beyond. Worldwide, the demonization of queerness perpetuates hostility and violence. At the same time, the queer/LGBTQI+ and feminine body is becoming central to the functioning of capitalism and the nation-state at multiple levels. From economic arrangements to security policy, historically marginalized people are no longer only at the receiving end of violence and dispossession. Today, Kurdishness and queerness face comparable geopolitical contradictions that speak to the changing role of identity politics under neoliberalism and neo-colonialism in the age of mass communication. What interventions can Kurdish queer/LGBTQI+ studies make to retain their critical, emancipatory impetus a hundred years after Lausanne, amid global mechanisms of punishment and reward for the oppressed, under changing conditions for academia and identity politics, and in times of war and occupation?
Establishment of CA19-9 reference intervals in an apparently healthy adult population in Singapore
Authors: Lee Joanne Mee Yin , Teo Pearline , Lam Leslie Choong Weng 
Published: December 2023

Background CA19-9 is elevated in pancreatic cancer and other malignancies, and commonly used in clinical practice. Unfortunately, CA19-9 immunoassays are not harmonized, and reference intervals may differ between assays. The aim of this study was to establish the reference interval of the ADVIA Centaur/Atellica IM CA19-9 assay in an apparently healthy Singapore adult population. Methods This is a retrospective cross-sectional study. De-identified data from Health Screening participants were extracted from our database. Subjects with biochemical results suggesting anaemia, diabetes mellitus, viral hepatitis or abnormal liver, and renal and tumour markers were excluded. Outlier and subclass analyses by age and sex were performed. CA19-9 reference limits and 90% confidence intervals were then determined for candidate subclasses. Results Data from 12,174 subjects (5846 males and 6328 females) were available after exclusion criteria were applied. CA19-9 results did not follow a normal distribution and were higher in females compared to males ( P < .001). Although CA19-9 means were statistically different between certain age groups, the evaluable 99th percentile reference limits were not statistically different. The overall 99th percentile reference limits for the Centaur/Atellica CA19-9 assay was 37 U/mL for males 21–80 years, and 60 U/mL for females 21–80 years. Conclusions Our results suggest that separate CA19-9 reference intervals should be applied for males and females.
The relationship of proximal lateral collateral ligament hyperintensity with knee joint ligament and meniscus pathologies
Authors: Cilengir Atilla Hikmet , Unal Sinan , Sinci Kazim Ayberk , Elmali Ferhan , Kucukciloglu Yasemin , Tosun Ozgur 
Published: December 2023

Background Hyperintensity in the proximal lateral collateral ligament (LCL) is often confusing. This appearance may be alone or accompany other pathologies. Purpose To investigate the relationship between the signal intensity (SI) change in the proximal LCL and the knee joint pathologies. Material and Methods The knee MRI scans taken between 2020 and 2022 were queried retrospectively. Patients with acute trauma, instability, knee surgery, or high-grade osteoarthritis were excluded. Included patients were divided into two groups as normal SI and increased SI according to proximal LCL. The difference in ligamentous and meniscal pathologies between the two groups was analyzed using a chi-square test. Inter-observer agreement analysis was performed on 50 randomly selected patients. Results A total of 351 patients (139 men [39.6%], 212 women [60.4%]; median age = 37 years; interquartile range = 67 years) were included. There were 114 (32.5%) LCLs with normal SI and 237 (67.5%) LCLs with increased SI. Normal SI and increased SI groups had a significant difference in terms of joint side, median age, patellar tendon SI, anterior cruciate ligament SI, and medial collateral ligament SI ( P = 0.004, P = 0.004, P = 0.001, P = 0.011, P = 0.004, respectively). A significant difference between the results of two separate LCL examinations in coronal + axial and coronal-only planes ( P <0.001). Inter-observer agreement was found to be good to excellent. Conclusion Hyperintensity in the proximal LCL was more common on the right joint side, in older patients, and patients with hyperintensity in the proximal patellar tendon, anterior cruciate ligament, and medial collateral ligament. Evaluating the LCL only in the coronal plane overestimates the hyperintensity.
Evaluation of placenta in patients with gestational diabetes using shear wave elastography and superb microvascular imaging
Authors: Çelik Ahmet Onur , Günay Burak , Çoker Gonca Büşra , Ustabaşıoğlu Fethi Emre , Ateş Sinan , Tunçbilek Nermin 
Published: December 2023

Background Gestational diabetes mellitus (GDM) is a common disease, and the placenta shows various functional and morphological changes in these patients. Superb microvascular imaging (SMI) and shear wave elastography (SWE) are innovative ultrasound (US) methods that provide detailed information about tissue vascularization and elasticity. Purpose To evaluate placental changes in patients with GDM with SMI and SWE methods. Material and Methods For this case-control study, 20 healthy and 20 women with GDM were included. Women at >21 weeks of pregnancy were evaluated with SMI and SWE by two independent radiologists. Mean SMI values and mean SWE values from three different region of interest-based measurements were compared between the two groups. Results We identified that the mean SMI and SWE value ​​of the GDM group was found to be significantly higher than that of the control group ( P = 0.002, P = 0.001 respectively). Using a receiver operating characteristic curve, the cutoff value of the SMI ratio, which maximizes the prediction of the presence of GDM, was 0.1234279750 (95% confidence interval [CI] = 0.625–0.920), the SWE cut-off value was 15.5 kPa (95% CI = 0.794–0.989). Conclusion We have demonstrated that evaluation with SMI and SWE might allow quantitative assessment of the morphological changes of placentas in women with GDM. We believe that the use of innovative methods such as SMI and SWE in addition to conventional US examinations in daily practice and studies will provide significant clinical benefits to patient management.
Improved radiologic diagnosis of delayed gastric conduit emptying (DGCE) after esophagectomy using a functional upper gastrointestinal contrast study
Authors: Hultcrantz Jens , Klevebro Fredrik , Lindblad Mats , Brismar Torkel B , Coy David L , Low Donald E , Andersson Mats 
Published: December 2023

Background With increasing incidence of esophageal cancer, a growing number of patients are at risk of developing delayed gastric conduit emptying (DGCE) in the early postoperative phase after esophagectomy. This condition is of great postoperative concern due to its association with adverse outcomes. Purpose To give a narrative review of the literature concerning radiological diagnosis of DGCE after esophagectomy and a proposal for an improved, functional protocol with objective measurements. Material and Methods The protocol was designed at Virginia Mason Medical Center in Seattle and is based on the Timed Barium Esophagogram (TBE) concept, which has been adapted to assess the passage of contrast from the gastric conduit into the duodenum. Results The literature review showed a general lack of standardization and scientific evidence behind the use of radiology to assess DGCE. We found that our proposed standardized upper gastrointestinal (UGI) contrast study considers both the time aspect in DGCE and provides morphologic information of the gastric conduit. This radiological protocol was tested on 112 patients in a trial performed at two high-volume centers for esophageal surgery and included an UGI contrast study 2–3 days postoperatively. The study demonstrated that this UGI contrast study can be included in the standardized clinical pathway after esophagectomy. Conclusion This new, proposed UGI contrast study has the potential to diagnose early postoperative DGCE in a standardized manner and to improve overall patient outcomes after esophagectomy.
Alda-1 ameliorates air embolism-induced acute lung injury
Authors: Wu Shu-Yu , Chu Shi-Jye , Tang Shih-En , Pao Hsin-Ping , Liao Wen-I 
Published: December 2023

Objective: Evidence suggests that aldehyde dehydrogenase 2 (ALDH2) offers protection against damage caused by oxidative stress in diverse rodent models. Nonetheless, the effect of Alda-1, a compound that activates ALDH2, on acute lung injury (ALI) induced by air embolism (AE) remains unclear. The objective of this study was to explore the protective effects of Alda-1 in ALI induced by AE. Methods: A rat model of in situ isolated perfused lung was established to investigate AE-induced ALI. Air was infused into the pulmonary artery at 0.25 mL/min for 1 minute. Before inducing AE, different doses (10, 20, or 30 mg/kg) of Alda-1 were given through intraperitoneal injection. Pathological changes in lung tissue were assessed using hematoxylin-eosin staining. We performed Western blot analysis to assess the protein levels of ALDH2,4-hydroxy-trans-2-nonenal (4-HNE), Bcl-2, caspase-3, phosphatidylinositol 3-kinase (PI3K), Akt, IκB-α, and nuclear NF-κB. Results: Notably, AE results were demonstrated as harmful to the lungs, which is evidenced by intensified lung edema and disruption of lung tissue structure. Furthermore, AE caused a decrease in ALDH2 expression, increased accumulation of 4-HNE and MDA, infiltration of neutrophils, increased production of inflammatory cytokines, apoptosis, and upregulation of the PI3K/Akt and NF-κB signaling pathways within the lungs. Administration of a 20 mg/kg dose of Alda-1 alleviated the detrimental effects induced by AE. Conclusion: Alda-1 shows promise in mitigating AE-induced ALI, possibly through the upregulation of ALDH2 expression and suppression of the PI3K/Akt and NF-κB signaling pathways. Further research is warranted to validate these findings and to explore their translational potential in human subjects.
Venous Thromboembolism Prophylaxis in Low Body Weight Critically Ill Patients
Authors: Knox Helena , Edwin Stephanie B. , Giuliano Christopher , Paxton Renee Alexander 
Published: December 2023

Objective To compare bleeding and thromboembolic events in low body weight patients receiving reduced-dose venous thromboembolism (VTE) prophylaxis versus standard-dose VTE prophylaxis. Design Multicenter, retrospective, cohort study. Setting Five Ascension Health Hospitals. Patients Adult, critically ill, low body weight (≤50 kg) patients who received either reduced-dose VTE prophylaxis (n = 140) or standard-dose VTE prophylaxis (n = 279) for at least 48 h. Intervention Reduced-dose prophylaxis (enoxaparin 30 mg daily or heparin 5000 units every 12 h subcutaneously) or standard-dose prophylaxis (enoxaparin 40 mg daily, enoxaparin 30 mg every 12 h, or heparin 5000 units every 8 h subcutaneously). Measurements and Main Results A total of 419 patients were included with a mean weight of 45.1 ± 4.2 kg in the standard-dose group and 44.0 ± 5.1 kg in the reduced-dose prophylaxis group ( P = .02). The primary endpoint, composite bleeding, was significantly lower in patients receiving reduced-dose prophylaxis (5% vs 12.5%, P = .02). After adjusting for confounding factors, results remained consistent demonstrating reduced composite bleeding with reduced-dose prophylaxis (odds ratio: 0.36, 95% confidence interval: 0.14-0.96). Major bleeding events occurred in 3.6% of reduced-dose patients compared with 8.6% in standard-dose patients ( P = .056). Clinically relevant nonmajor bleeding (5.4% vs 2.9%, P = .24) and VTE (2.2% vs 0%, P = .08) events were similar between groups. Conclusions A reduced-dose VTE prophylaxis strategy in low body weight, critically ill patients was associated with a lower risk of composite bleeding and similar rate of thromboembolism.
Long COVID – Can we deny a diagnosis without denying a person’s reality?
Authors: Little John , Higgins Matthew , Palepu Radhika 
Published: December 2023

Objective The aim is to consider Long COVID not as a new clinical entity but as another example of a disabling, historical phenomenon. Conclusions A triad of polymorphic symptomatology, an elusive pathophysiological explanation and a hostile defensiveness has appeared throughout history. The reluctance to consider these contextually may delay early intervention and appropriate patient care.
The Impact of Social Determinants of Health on the Diagnosis of Type 2 Diabetes Mellitus (T2DM) Among Asian Indians (AIs) in New Jersey: A Secondary Analysis of the BRFSS Survey From 2013 to 2017
Authors: Joseph Maya Ellampally , D’Alonzo Karen T. , Btoush Rula , Fitzgerald Nurgul 
Published: December 2023

Introduction: Asian Indians (AIs), the second largest immigrant population in the United States, are disproportionately affected by type 2 diabetes mellitus (T2DM) at a lower age and body mass index (BMI). The purpose of this study was to examine the relationship between social determinants of health (SDOH) and the diagnosis of T2DM among AIs in New Jersey (NJ). Methodology: This was a secondary data analysis of the Behavioral Risk Factor Surveillance System (BRFSS) in NJ from 2013 to 2017. Statistical analyses included descriptive and inferential statistics. Results: Among 1,132 AIs, 16% had T2DM or prediabetes (PDM) and 69.2% were overweight or obese. The risk for T2DM was significantly associated with internet use, older age, having medical check-ups, and having a personal doctor ( p ≤ .05). Discussion: These findings inform culturally congruent care by underscoring the importance of weight management, earlier screening, and provider involvement in diabetes prevention strategies for AIs.
What Matters Most: The Documented Goals, Values and Motivators of Advanced Cancer Patients
Authors: Aller Ashley , Shirazi Aida , Pedell Leon , Altschuler Andrea , Hauser Karen , Cheslock Megan , Wei Jenny , Duffens Ali , Whitehead Hannah , Lim Peggy , Katzel Jed , Martinez Francisco , Lin Amy , Aller Steve , Aller Cynthia , Jones Tyler , Yen Sue May , Liu Raymond 
Published: December 2023

Background Goals of care conversations are essential to delivery of goal concordant care. Infrequent and inconsistent goals of care documentation potentially limit delivery of goal concordant care. Methods At Kaiser Permanente San Francisco Cancer Center, a standardized documentation template was designed and implemented to increase goals of care documentation by oncologists. The centralized, prompt-based template included value clarification of the goals and values of advanced cancer patients beyond treatment preferences. Documented conversations using the template during the initial pilot period were reviewed to characterization the clinical context in which conversations were recorded. Common goals and motivators were also identified. Results A total of 178 advanced cancer patients had at least 1 documented conversation by a medical oncologist using the goals of care template. Oncologists consistently documented within the template goals of therapy and motivating factors in decision making. The most frequently documented goals of care were “Avoiding Pain and Suffering,” “Physical Independence,” and “Living as Long as Possible.” The least recorded goal was “Comfort Focused Treatment Only.” Conclusions Review of oncologist documented goals of care conversations using a prompt-based template allowed for characterization of the clinical context, therapy goals and motivators of advanced cancer patients. Communication of goals of care conversations by oncologists using a standardized prompt-based template within a centralized location has the potential to improve delivery of goal concordant care.
Use of venetoclax in t(11;14) positive relapsed/refractory multiple myeloma: A systematic review
Authors: Khan Wardah Javed , Ali Mubeen , Hashim Sana , Nawaz Huma , Hashim Syeda Nafeesa , Safi Danish , Inayat Arslan 
Published: December 2023

Background The plasma cell malignancy, multiple myeloma (MM), remains incurable despite advanced treatment protocols. Overexpression of Bcl-2 (an anti-apoptotic protein), in MM harboring the translocation (11;14), contributes to resistance to prior therapy. Venetoclax, a selective oral inhibitor of BCL-2 is a novel agent that shows promise as a therapeutic agent. Aims The objective of this systematic review is to address how the use of venetoclax, alone or as a combination regimen, contributed to the treatment of patients with t(11:14) positive relapsed/refractory multiple myeloma (RRMM). Data sources This systematic review was conducted in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was done on 5th June 2022. A literature search was conducted on PubMed and Scopus, 145 articles were screened and 10 studies were included. Risk of bias assessment was performed using the Methodological Index for Non-Randomized Studies (MINORS) criteria. Data summary Across the studies reviewed, a total of 311 patients were identified with t(11;14) positive RRMM. The overall response rate achieved ranged between 33% and 95.5%. Furthermore, the use of venetoclax has exhibited a favorable adverse effect profile. Side effects included hematological side effects, nausea, vomiting, and diarrhea. Conclusion Venetoclax demonstrates promising results. When given with drugs like dexamethasone, daratumumab and carfilzomib, a synergistic effect is seen in treating translocation (11:14) positive relapsed/refractory MM. The use of venetoclax in clinical practice can potentially improve outcomes and quality of life in RRMM patients, and future research should continue to explore this promising treatment option.
Optimizing chemotherapy medication leftover management circuit in a centralized chemotherapy preparation unit: A comprehensive FMECA risk analysis and continuous improvement approach
Authors: El Baraka Soumaya , Chennaq Meryem , Ouedraogo Jean-Marie , Cherif Chefchaouni Ali , Shytry Oumaima , Belahcen Mohammed-Jaouad , Rahali Younes 
Published: December 2023

Objective Chemotherapy medications are usually having high costs, and new targeted drugs can be especially expensive, representing a challenge on healthcare, particularly in low- and middle-income countries. As cytotoxic leftover management is crucial for reducing medication wastage, the aim of this study is to evaluate and optimize leftover management circuit in NIO’S Pharmacy Centralized Chemotherapy Preparation Unit (CCPU) through a Failure Mode, Effects and Criticality Analysis (FMECA), and propose continuous improvement element to enhance the security of the process. Method The FMECA were conducted in NIO’s CCPU from March to May 2023, then continuous improvement plan was established to enhance the security of the process. The failure modes, their causes, impact, and criticality were assessed through criticality index calculation (CI = severity × frequency × detectability), and the risk concerned safety and effectiveness disruptions in chemotherapy preparation circuit using cytotoxic leftover. Results Leftover management circuits were described in flowchart form, where 18 failure modes were detected in four different steps of the process from chemotherapy preparation to disposal. Failure with highest critical index were detected in the case of equipment malfunction, improper storage temperature, and humidity. Continuous improvement recommendations were proposed in a table form. Conclusion FMECA analysis applied to NIO’s chemotherapy leftover management process allowed us to evaluate, secure, and optimize the circuit, and to propose several actions to implement in a perspective of continuous improvement.
Psychological Effect of the COVID-19 Pandemic on Nursing Students: Palestinian Perspective
Authors: Abu Liel Farid 
Published: December 2023

Introduction COVID-19 has had an important effect on nursing students, with some having their clinical practice cancelled or suspended and others suffering from the virus. Objective The purpose of this study was to assess the psychological status in terms of stress, anxiety, and depression of nursing students during COVID-19 pandemic. Methods The study was cross-sectional, carried out by a convenience sample of 320 participants of nursing students between May and June 2020. Data collection was performed by “Depression Anxiety Stress-21 Scale” (DASS-21). Results The results revealed that 78 (24.3%) of participants reported stress; 121 (37.8%) reported anxiety; and 72 (22.5%) reported depression. Also, grade and socioeconomic status had statistically significant effect on anxiety, stress, and depression. In addition, age had statistically significant effect on depression, place of residence had statistically significant effect on anxiety, and gender had statistically significant effect on stress. Conclusion The study confirmed an alarming number of nursing students who experienced anxiety, stress, and depression. This study serves as an evidence concerning nursing students’ mental health issues as a consequence of the COVID-19 pandemic.