bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review
Authors: Brufatto Matheus Zanata , Lanças Sean Hideo Shirata , Fernandes Taciana Taciana de Albuquerque Pedrosa , Elias Adriana Adriana Maluf , Campos Lucia Maria Arruda , Sakamoto Ana Paula , Terreri Maria Teresa , Sztajnbok Flavio Roberto , Bica Blanca Elena Rios Gomes , Ferriani Virginia Paes Leme , de Carvalho Luciana Martins , Silva Clovis Artur Almeida , Saad-Magalhaes Claudia 
Published: November 2023

Abstract

Background
Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis.
Method
A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol.
Results
Of the 1757 cSLE cases in the updated cohort, 12 (0.7%) developed malignancy with median time 10 years after cSLE diagnosis. There were 91% females, median age at cSLE diagnosis 12 years, median age at malignancy diagnosis 23 years. Of all diagnosed malignancies, 11 were single-site, and a single case with concomitant multiple sites; four had haematological (0.22%) and 8 solid malignancy (0.45%). Median (min-max) SLEDAI-2K scores were 9 (0–38), median (min-max) SLICC/ACR-DI (SDI) score were 1 (1–5) Histopathology defined 1 Hodgkin's lymphoma, 2 non-Hodgkin's lymphoma, 1 acute lymphoblastic leukaemia; 4 gastrointestinal carcinoma, 1 squamous cell carcinoma of the tongue and 1 anal carcinoma; 1 had sigmoid adenocarcinoma and 1 stomach carcinoid; 3 had genital malignancy, being 1 vulvae, 1 cervix and 1 vulvae and cervix carcinomas; 1 had central nervous system (CNS) oligodendroglioma; and 1 testicle germ cell teratoma.
Conclusion
Estimated malignancy frequency of 0.7% was reported during cSLE follow up in a multicentric series. Median disease activity and cumulative damage scores, by the time of malignancy diagnoses, were high; considering that reported in adult series.
Assessment of Nomadic Pastoralists' Livelihood Vulnerability to Climate Change in the Third Pole Region: A Case Study of Western Mongolia
Authors: Ochir Altansukh , Lee Woo-Kyun , Wang Sonam Wangyel , Demberel Otgonbayar , Enkhsaikhan Undarmaa , Turbat Byambadash , Lamchin Munkhnasan , Monkhbat Bayarmaa , Namsrai Oyunchimeg 
Published: November 2023

Abstract

The High Mountains of Asia, called the "Third Pole" because they have the third largest reserve of water after the North and South poles, are an important landscape around the world. Mongolia is one of the countries that make up the Third Pole. The high mountains of Mongolia and its ecosystems, including the nomads that live there, are fragile and vulnerable to the slightest change in the environment. Based on the household interviews with nomads in the Tsambagarav and Munkh Khairkhan Mountains, we used a sustainable livelihood approach to assess the livelihood vulnerability index of the nomads. Findings indicate that the overall LVI was 0.41 for Tsambagarav and 0.44 for Munkh Khairkhan, and the corresponding IPCC-LVI was 0.01 for Tsambagarav and − 0.02 for Munkh Khairkhan. Based on the findings, we recommend that decision-makers focus on setting up an appropriate number of livestock that can be owned by one household, the proper structure of livestock, effective management of pasture land, and an insurance-based compensation system for livestock. Moreover, to develop a mobile-economy informative early warning system this can be a new innovative idea to prevent climate change disasters. These actions can contribute to a long-term sustainable livelihood in the fast-changing climate.
Application of GALDIT Approach for Sea water intrusion vulnerability assessment: A case study of Bhubaneswar and its buffer zone, Odisha
Authors: Sarangi Manorama , Kar Anil Kumar 
Published: November 2023

Abstract
Salt water intrusion is a growing concern for coastal and nearby areas. The application of ground water and its over exploitation is the main cause of sea water intrusion. Ground water is being pumped from the aquifers and those aquifers are hydraulically connected with sea. The pumping induces a hydraulic gradient which cause the moving of sea water towards ground water in that excessive pumping area and it aggravates due to reduction of fresh water inflows. As the use of pure ground water is highly essential for developmental uses, it is necessary to determine the sea water intrusion particularly for coastal areas and its nearby cities. The vulnerability of sea water intrusion has been studied at Bhubaneswar city, the capital of Odisha, India including its buffer zone upto the coastal city Puri, using GIS based GALDIT method. The six important factors those are, Ground water occurrence (G) ; Hydraulic Conductivity (A) ; Depth of ground water level (L) ; Distance from Shore (D) ; Impact of existing salt water intrusion (I) ; Aquifer thickness (T) are taken into consideration. The data are ranked as per their contribution to salination and the thematic maps are overlayed using GIS in order to make the vulnerability analysis. The study shows that, the Bhubaneswar city has very less vulnerability to sea water intrusion upto the time period of analysis.
Guidelines to design a neural network as a feedforward controller for fast trajectory tracking of robotic arms
Authors: Toussaint Baptiste , Raison Maxime 
Published: November 2023

Abstract
Tracking fast and accurate trajectories of robotic arms can be important in applications involving large movements, velocities, and accelerations. This would require either an accurate dynamic model of the arm or an aggressive tracking with high-gain feedback. Concretely, it can be difficult to obtain the accurate model, due to nonlinearities and uncertainties. Current developments of 3D-printed and low-cost robotic arms accentuate this issue. Control architectures for high-speed trajectory tracking requiring no dynamic model were recently proposed. These consist in learning the dynamic response of a proportional derivative controller with a neural network (NN) as feedforward controller. However, no detail was provided to make the most of these architectures. This paper aims to provide guidelines for an optimal design of a neural network (NN) as feedforward controller for fast and accurate trajectory tracking of robotic arms. The subsequent objective is to compare 1. one NN per individual joint (INN’s method); and 2. one global NN (GNN method). The method compares these two architectures. Results are illustrated with two serial robotic arms of 3 and 5 degrees of freedom, simulated then in reality. The main results are as follows: The control architecture reduces the trajectory tracking errors (RMSE < 2°). The INN’s method can be used when the joints dynamics are decoupled and requires less data than GNN method to learn the dynamics. A table sums up the guidelines for design, in five main steps. Perspectives are to apply these guidelines to develop low-cost robotic arms and extend to micro-movements.
Impact of Satellite Precipitation Estimation Methods on the Hydrological Response: Case studies Wadi Nu’man Basin, Saudi Arabia
Authors: Adem Esubalew , Elfeki Amro , Chaabani Anis , Alwegdani Abdullah , Hussain Sajjad , Elhag Mohamed 
Published: November 2023

Abstract
Accurately estimating precipitation is essential for managing water resources and assessing hydrological systems, particularly in small basins. The main goal of the current study is to determine how different methods for estimating precipitation affect the hydrological response, or runoff, in the Wadi Nu'man basin in Saudi Arabia. Rainfall data was collected from ground observations and satellite rainfall products for a period of thirteen years (2006–2018). The satellite precipitation data was collected from the Tropical Rainfall Measuring Mission (TRMM-3B42), TRMM-Realtime (TRMM-3B42RT), and Climate Hazards Group InfraRed Precipitation (CHRIPS) and compared with station data for reliability analysis. Additionally, a linear scaling bias correction method was employed between satellite and ground-based station data. The HEC-HMS model was used to simulate the runoff under all available bias-corrected precipitation datasets. Different statistical matrices assessed the performance of the satellite dataset based on observed rainfall and simulated runoff. In rainfall data assessment, a strong regression (R2 = 0.90) for CHIRPS, the lowest for TRMM-3B42RT (R2 = 0.20), and a moderate regression (R2 = 0.60) for TRMM-3B42 were found as compared to observed rainfall. As for runoff modeling, the HEC-HMS model exhibited a very high regression (R2) value of 0.99 between peak discharges generated by gauges and satellite (TRMM and CHRIPS) rainfall. Overall, this research emphasizes the utilization of bias-corrected TRMM and CHRIPS precipitation datasets for runoff and hydrological water balance estimation in small wadies like Wadi Nu'man. Future studies focusing on implementing complex bias correction techniques, testing diverse satellite datasets, and integrating advanced modeling tools like machine learning offer the potential to significantly refine and expand the accuracy of hydrological predictions, vital for decision support systems in water resource management.
Shear bond strength of a RMGIC for orthodontic bracket bonding to enamel
Authors: DANTAGNAN Claire-Adeline , BOUDROT Maureen , FRANCOIS Philippe , ABDEL-GAWAD Sarah , Attal Jean-Pierre 
Published: November 2023

Abstract
Objective: To evaluate the shear bond strength (SBS) of a restorative resin-modified glass ionomer cement (RMGIC) for orthodontic bracket bonding.
Materials and Methods: 121 human teeth were randomly divided into 11 groups (n=11) according to the surface treatment applied (H3PO4 ± Transbond Plus (TSEP) or Scotchbond Universal (SU)), and the adhesive used (Riva LC HV (RIVA), Fuji Ortho (FUJI), and Transbond XT (TXT)). For each sample, a metal button was bonded. SBS tests were performed at one week and debonded specimens were observed for failure modes determination. One-way ANOVA followed by Tukey's post hoc test was used to compare SBS differences and Fisher's exact test to analyse the failure modes (p<0.05).
Results: TSEP + FUJI and H3PO4+ SU + TXT showed the highest SBS values while H3PO4+ TSEP + RIVA showed the lowest value. Cohesive failure and mixed failure were found in the groups with SU and TXT and adhesive failure in the other groups.
Discussion/Conclusions: The bonding of orthodontic attachments to enamel could be performed with any of the three materials studied. The use of a universal adhesive in the bonding protocol could optimize the adhesion values. Clinical studies would be needed to confirm the results obtained.
Potential Drug-Drug Interaction Detection Using the Uptodate Mobİle Application in Intensive Care: A Retrospective, Observational Study
Authors: Kayhan Munevver , Kayhan Oguzhan , Dikmen Yalim , Ozturk Mehmet Aykut 
Published: November 2023

Abstract
Purpose: It was aimed to investigate the frequency of potential drug-drug interactions (pDDI) and the effect of the number of drugs used on pDDI with the Uptodate drug interactions application.
Methods: Patients older than 12 years of age who were treated in the intensive care unit for 3 days or more in 2016 were included in the study. pDDIs were detected by entering the drugs used for more than 24 hours into the Uptodate application. The total number of mild, moderate and severe pDDIs and the number of medications used, length of stay, age, number of chronic diseases, mechanical ventilation (MV) support, hospitalization diagnoses, and APACHE II score were compared statistically.
Results: While PIE was found to increase with the number of medications administered, it was found that it did not show an exact association with the number of days of hospitalization. However, it was higher in patients who received MV support, had a high APACHE II score, and died. pDDI was seen least in the postoperative follow-up diagnosis group.
Conclusion: It was determined that pDDI increased as the number of medications used in critically ill patients increased.
Comparison of keratometric values and anterior segment parameters measured using Scheimpflug Sirius topography and Lenstar biometry
Authors: Telek Hande Hüsniye , Bilen Rabia Büşra Akden , Özdemir Yaprak Arzu , Dinç Damla Nur , Çelikay Osman 
Published: November 2023

Abstract

Purpose: This study aimed to evaluate the consistency of preoperative keratometric values, anterior segment, and intraocular lens (IOL) power measurements in patients with cataract and no comorbidities using the Sirius topography device (CSO, Italy) and Lenstar LS 900 (Haag–Streit AG, Köeniz, Switzerland).
Methods: The study involved patients with Grade 2 and 3 cataracts presented to and scheduled for surgery at the Ophthalmology Clinic of Dışkapı Yıldırım Beyazıt Education and Research Hospital, University of Health Sciences. Forty eyes with cataract from 40 patients were included in the study. All patients underwent preoperative assessment using a combined Scheimpflug–Placido disc-based tomography device (Sirius) and Lenstar before cataract surgery. Keratometric measurements, such as flat keratometry (K1), steep keratometry (K2), and maximum keratometry (Kmax), and anterior segment parameters, white-to-white (WTW) distance, IOL power, astigmatism (AST), anterior chamber depth (ACD), aqueous depth (AD), and central cornea thickness (CCT), were recorded.
Results: There were significant differences between K1Lenstar and K1Sirius, K2Lenstar and K2Sirius, KmaxLenstar and KmaxSirius, WTWLenstar and WTWSirius, and IOL powerLenstar vs. IOL powerSirius. However, there were insignificant differences between ASTLenstar and ASTSirius, ACDLenstar vs. ACDSirius, ADLenstar and ADSirius, and CCTLenstar and CCTSirius variables. Furthermore, comparison of Sirius and Lenstar in terms of IOL power showed that Lenstar significantly underestimated IOL values compared with those of Sirius.
Conclusion: Significant differences were observed between Lenstar and Sirius in terms of keratometric values, WTW distance, and IOL power. IOL power measurements were more accurate using the Sirius topography device.
Identifying Evidence-Based Quality Indicators to Measure Workplace Violence in Healthcare Settings: A Rapid Review
Authors: Lyver Brendan , Gorla Jaswanth , Schulz-Quach Christian , Anderson Melanie , Singh Brendan , Hanagan Trevor , Haines Jennifer , Sethi Rickinder 
Published: November 2023

Abstract
Background. Workplace violence (WPV) in healthcare is a growing challenge posing significant risks to patient care and employee well-being. Existing metrics to measure WPV in healthcare settings often fail to provide decision-makers with an adequate reflection of WPV due to the complexity of the issue. This increases the difficulty for decision-makers to evaluate WPV in healthcare settings and implement interventions that can produce sustained improvements.
Objective. This study aims to identify and compile actionable and comprehensive evidence-based quality indicators that can effectively measure the impacts of WPV interventions in healthcare settings and provide leadership with the necessary information to make decisions related to WPV.
Methods. Ovid databases were used to identify articles relevant to violence in healthcare settings, from which 43 publications were included for data extraction. Data extraction produced a total of 229 quality indicators that were sorted into three indicator categories using the Systems Engineering Initiative for Patient Safety (SEIPS) model: structure, process, and outcome.
Results. A majority of the articles (93%) contained at least 1 quality indicator that possessed the potential to be operationalized at an organizational level. In addition, several articles (40%) contained valuable questionnaires or survey instruments for measuring WPV. In total, the rapid review process identified 84 structural quality indicators, 121 process quality indicators, 24 outcome quality indicators, 57 survey-type questions and 17 survey instruments.
Conclusions. This study provides a foundation for healthcare organizations to address WPV through systematic approaches informed by evidence-based quality indicators. The utilization of indicators showed promise for characterizing WPV and measuring the efficacy of interventions. Caution must be exercised to ensure indicators are not discriminatory and are suited to specific organizational needs. While the findings of this review are promising, further investigation is needed to rigorously evaluate existing literature to expand the list of evidence-based quality indicators for WPV.
Endophyte Chaetomium, Potential Bioactivity: Pharmaceutical and Phytochemical Analyses
Authors: Kheiralla Zeinab M.H. , Abo-Ghalia Hoda H. , Elaasser Mahmoud M. , Hemeda Manal F. , Ibrahim Sahar Y. 
Published: November 2023

Abstract
Endophytic fungi establish mutualistic symbiotic relationships with plants, wherein their interactions facilitate the production of bioactive secondary metabolites by the fungal cells. The objective of this study is to examine the antioxidative, anticancer, cytotoxic, and antiviral properties of crude metabolites from the fungal endophytes Chaetomium laterale LC4146 and Chaetomium interruptum CBS126660. Chromatographic separation and metabolic main chemical identification were also addressed. Semi-purified extracts showed radical-inhibiting or 2,2-diphenyl-1-picrylhydrazyl-radical-scavenging capabilities. The crude ethyl acetate extract of C. interruptum has the highest inhibitory activity against human liver (HepG2), prostate (PC-3), and colorectal (HCT-116) cancer cells and interestingly shows low toxicity to normal Vero African Green Monkey kidney cells. Fungi extract exerted dose-dependent anticancer effects on three cancer cell lines, with observable alterations in the shape and morphology of HepG2 cells under an inverted microscope. To test the in vitroanti- Herpes Simplex Virus type-1 (HSV-1) efficiency of ethyl acetate and petroleum ether extracts, the cytopathic effect inhibition was weak to moderate. Phytochemical examination of fungal extracts revealed phenolics, esters, alcohols, and hydrocarbons. Hexanedioic acid, 2,4-ditert-butylphenol, 1,2-benzene dicarboxylic acid, and 1-hexadecanol are the most bioactive successful chemicals. Since these unique bioactive components of fungal extract were acceptable in vitro, the two Chaetomium species may be a viable source of natural products and a good starting point for medicinal applications.
Modelling of a hybrid wind power generator–water distillation system using a Venturi tunnel
Authors: Naji Malak I. , Al-Nimr M. A. 
Published: November 2023

Abstract

This study presents the development of a novel hybrid wind power generator–water distillation system with the objective of providing sustainable solutions for impoverished isolated communities facing limited resources. The advantage of the proposed system is its ability to operate day and night; therefore, it produces larger quantities of distilled water even on cloudy days with winds. The system comprises a Venturi tunnel integrated with a wind turbine, an attached impure water tank, and a condenser located at the end section. The accelerated airflow at the throat section serves two purposes: water evaporation from the tank and power generation through the wind turbine. The evaporated water is subsequently collected as the airflow decelerates and the pressure decreases along the diverging section. Theoretical and computational modelling is employed to design the system by examining air speed, area ratio, relative humidity, as well as air, and water temperatures. The system exhibits enhanced performance under warm and dry weather conditions, thereby optimizing its performance. Conversely, temperature and relative humidity do not affect power generation; it was increased by higher air speeds and larger area ratios. This data-driven approach ensures optimal design parameters are selected, aligning the system's capabilities with the specific freshwater demand.
Effects of Digital Physical Health Exercises on Musculoskeletal Diseases: Systematic Review With Best-Evidence Synthesis
Authors: Nagel Johanna , Wegener Florian , Grim Casper , Hoppe Matthias Wilhelm 
Published: November 2023

Background
Musculoskeletal diseases affect 1.71 billion people worldwide, impose a high biopsychosocial burden on patients, and are associated with high economic costs. The use of digital health interventions is a promising cost-saving approach for the treatment of musculoskeletal diseases. As physical exercise is the best clinical practice in the treatment of musculoskeletal diseases, digital health interventions that provide physical exercises could have a highly positive impact on musculoskeletal diseases, but evidence is lacking.

Objective
This systematic review aims to evaluate the impact of digital physical health exercises on patients with musculoskeletal diseases concerning the localization of the musculoskeletal disease, patient-reported outcomes, and medical treatment types.

Methods
We performed systematic literature research using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search was conducted using the PubMed, BISp, Cochrane Library, and Web of Science databases. The Scottish Intercollegiate Guidelines Network checklist was used to assess the quality of the included original studies. To determine the evidence and direction of the impact of digital physical health exercises, a best-evidence synthesis was conducted, whereby only studies with at least acceptable methodological quality were included for validity purposes.

Results
A total of 8988 studies were screened, of which 30 (0.33%) randomized controlled trials met the inclusion criteria. Of these, 16 studies (53%) were of acceptable or high quality; they included 1840 patients (1008/1643, 61.35% female; 3 studies including 197 patients did not report gender distribution) with various musculoskeletal diseases. A total of 3 different intervention types (app-based interventions, internet-based exercises, and telerehabilitation) were used to deliver digital physical health exercises. Strong evidence was found for the positive impact of digital physical health exercises on musculoskeletal diseases located in the back. Moderate evidence was found for diseases located in the shoulder and hip, whereas evidence for the entire body was limited. Conflicting evidence was found for diseases located in the knee and hand. For patient-reported outcomes, strong evidence was found for impairment and quality of life. Conflicting evidence was found for pain and function. Regarding the medical treatment type, conflicting evidence was found for operative and conservative therapies.

Conclusions
Strong to moderate evidence was found for a positive impact on musculoskeletal diseases located in the back, shoulder, and hip and on the patient-reported outcomes of impairment and quality of life. Thus, digital physical health exercises could have a positive effect on a variety of symptoms of musculoskeletal diseases.