bluuebunny/crossref_metadata_2025_split huggingface dataset:
The gut microbiome predicts response to UDCA/CDCA treatment in gallstone patients: comparison of responders and non-responders
Authors: Lee Jungnam , Park Jin-Seok 
Published: January 2024

AbstractThe treatment of gallbladder (GB) stones depends on condition severity. Ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) are commonly used to treat GB stones, but the factors affecting response rates have not been fully identified. Therefore, we investigated the relationship between response to UDCA/CDCA treatment and changes in the gut microbiomes of patients with GB stones with the intention of identifying gut microbiomes that predict susceptibility to UDCA/CDCA treatment and treatment response. In this preliminary, prospective study, 13 patients with GB stones were treated with UDCA/CDCA for 6 months. Patients were classified into responder and non-responder groups based on treatment outcomes. Gut microbiomes were analyzed by 16S rDNA sequencing. Taxonomic compositions and abundances of bacterial communities were analyzed before and after UDCA/CDCA treatment. Alpha and beta diversities were used to assess similarities between organismal compositions. In addition, PICRUSt2 analysis was conducted to identify gut microbial functional pathways. Thirteen patients completed the treatment; 8 (62%) were assigned to the responder group and the remainder to the non-responder group. Low abundances of the Erysipelotrichi lineage were significantly associated with favorable response to UDCA/CDCA treatment, whereas high abundances of Firmicutes phylum indicated no or poor response. Our results suggest that a low abundance of the Erysipelotrichi lineage is significantly associated with a favorable response to UDCA/CDCA and that a high abundance of Firmicutes phylum is indicative of no or poor response. These findings suggest that some gut microbiomes are susceptible to UDCA/CDCA treatment and could be used to predict treatment response in patients with GB stones.
Déploiement des réacteurs innovants : que veulent les start-up ?
Authors: Le Gros Gaïc 
Published: January 2024

En octobre 2023, les start-up ont salué l’initiative gouvernementale de l’appel à projets « Réacteurs innovants » tout en demandant des axes d’amélioration dans le cadre d’une transformation rapide de l’écosystème nucléaire.
Chapter 6. The pantomimic origins of the narrative arts
Authors: Brown Steven 
Published: January 2024

The evolutionary study of pantomime provides important insights into the origins of the narrative arts, including visual art, theatre, and narrative forms of dance (e.g., ballet). Drawing, as a motoric activity, shows a strong resemblance to tracing pantomimes. The main difference is that drawing generates an enduring image on a surface, whereas pantomime is “drawing in the air.” The theatrical arts – including dramatic acting, mime acting, and narrative forms of dance – take a more egocentric approach to pantomime than drawing, employing full-body mimicry of the expressive actions of a referent person. Overall, iconic gesturing through pantomime provides an evolutionary foundation for all of the narrative arts. On the flip side, a consideration of the narrative arts themselves provides many new avenues for the exploration of pantomime, including shedding light on gestural models of the origins of language.
Towards a successful implementation of buildability assessment in construction industry: a conceptual framework
Authors: Osuizugbo Innocent Chigozie , Ezeokoli Fidelis Okechukwu , Okolie Kevin Chuks , Olojo Aduragbemi Deborah 
Published: January 2024

Purpose
The application of good buildability practices is vital for improving the performance of projects and businesses in the construction sector. Despite the plethora of research into buildability in construction in the previous years, there is little information concerning how buildability practice can be successfully implemented. This paper aims to develop a conceptual framework that explains how buildability practice can be implemented successfully in the construction industry.

Design/methodology/approach
The paper uses an integrative literature review method to synthesise literature from different domains to describe various themes by which buildability assessment can be successfully implemented in the construction industry.

Findings
The findings of the review of literature conceptualised a buildability implementation framework at four principal themes: buildability attributes for improving the practice of construction management, factors supporting the implementation of buildability assessment, measures for improving the buildability of building designs and factors impeding the implementation of buildability assessment.

Originality/value
The outcome of this study contributes to knowledge in three different ways. First, the framework emerging from this study provides guidance to stakeholders on strategies for the successful implementation of buildability. Second, the information gathered in this study is useful for the development of buildability assessment tool. Finally, the framework has a potential of improving the practice of embedding buildability into designs. The detailed descriptions of the relevant variables at each principal theme advance the understanding of buildability in the construction industry and are fundamental to developing buildability assessment tools for the industry.
Characterization of decorticated fibres from agricultural waste of the Curcuma longa plant and their non-woven fabric properties
Authors: Wardiningsih Wiah , Syauqi Pradanta Farhan Aqil , Rudy Ryan , Hernawati Resty Mayseptheny , Sugiyana Doni 
Published: January 2024

Purpose
The purpose of this study is to analyse the characteristics of cellulose fibres derived from the pseudo-stems of Curcuma longa and to evaluate the properties of non-woven fabric produced using these fibres.

Design/methodology/approach
The fibres were extracted via a decortication method. The acquired intrinsic qualities of the fibres were used to assess the feasibility of using them in textile applications. The thermal bonding approach was used for the development of the non-woven fabric, using a hot press machine with low-melt polyester fibre as a binder.

Findings
The mean length of Curcuma longa fibres was determined to be 52.73 cm, with a fineness value of 4.00 tex. The fibres exhibited an uneven cross-sectional morphology, characterized by a diverse range of oval-shaped lumens. The fibre exhibited a tenacity of 1.45 g/denier and an elongation value of 4.30%. The fibres possessed a moisture regain value of 11.30%. The experimental non-woven fabrics had consistent weight and thickness, while exhibiting different properties in terms of tensile strength and air permeability, with Fabric C having the highest tensile strength and the lowest air permeability value.

Originality/value
The features of Curcuma longa fibre, obtained with the decortication process, exhibited suitability for textile applications. Three experimental non-woven fabrics comprising different compositions of Curcuma longa fibre and low-melt polyester fibre were produced. The tensile strength and air permeability properties of these fabrics were influenced by the composition of the fibres.
Do summative entrustment decisions actually lead to entrustment?
Authors: Sigurdsson Vigfús , ten Cate Olle 
Published: January 2024

AbstractBackgroundEntrustable professional activities (EPAs) were introduced across Dutch postgraduate programmes between 2017 and 2019. We aimed to understand the extent to which residents actually were granted increased clinical responsibility upon receiving summative entrustment for an EPA, a critical feature of its use.MethodsA survey study was conducted among all Dutch residents who started dermatology training in 2018 and 2019 and all Dutch dermatology programme directors (PDs). We chose an EPA designed for early entrustment in residency (identification, treatment and care regarding a simple dermatological problem in the ambulatory setting). The survey contained two hypothetical clinical cases that aligned with this EPA. The questions were aimed to determine whether and when residents should request supervision. Similar questions were posed to PDs.FindingsTwenty four residents (56%) and 19 PDs (79%) completed the survey. The majority of the residents (65%) and PDs (63%) confirmed that competent dermatology residents (level 4) are generally allowed to perform EPA1 unsupervised, particularly when seeing patients from GPs. However, still a substantial proportion of the level 4 residents, working in University Medical Centers (36%) indicated that they had to request supervision in the assessment of these patients. For 2nd opinions, the results were typically the opposite.Discussion and ConclusionThis study demonstrated that, at least in one specialty and one country, the introduction of EPAs and entrustment decision making procedure generally led to the intended autonomy of the resident.
Temporal trend in hospitalizations for malignant neoplasm and benign neoplasm: a nationwide study, China, 2004–2020
Authors: Zhang Xinqiang , Li Yuanyuan , Zhang Guifang , Ma Changsheng , Liu Bo , Yin Yong 
Published: January 2024

AbstractThe increasing cancer burden calls for reliably assessed changes in the hospitalizations for tumors over time and space in China. This study evaluated trends in hospitalization rate, in-hospital mortality, length of stay (LOS), and medical costs for malignant and benign neoplasms. Data were derived from China Health Statistical Yearbooks from 2004 to 2020. Temporal trends in hospitalization rates and in-hospital mortality rates were assessed through the Cochran-Armitage Test. We used the linear model with continuous variables to test for the trend. The malignant neoplasm hospitalization rate increased from 1.1‰ to 5.8‰ and the benign neoplasm increased from 1.0‰ to 2.0‰. The in-hospital mortality rate due to malignant neoplasm and benign neoplasm decreased from 5.11 to 2.87% (P for trend < 0.001) and 0.14–0.01% (P for trend < 0.001), respectively. Among all patients hospitalized with malignant neoplasm, the average cost per hospitalization significantly increased during the study period (P for trend < 0.001), adjusted for the Consumer Price Index. However, the average LOS gradually decreased (P for trend < 0.001). In line with the trend of malignant neoplasm, the average cost per hospitalization increased significantly among all patients hospitalized for benign neoplasm (P for trend < 0.001), and the average LOS showed a steady downward trend (P for trend < 0.001). We found upward trends in hospitalization rates, and medical costs in neoplasms. By contrast, substantial decreases in in-hospital mortality and LOS. The hospitalization rate gap between urban and rural areas is narrowed.
Meta-synthesis of qualitative studies to explore fathers’ perspectives of their influence on children’s obesity-related health behaviors
Authors: Park Eunyoung , Jang Myoungock , Jung Mi Sook , Dlamini Nondumiso Satiso 
Published: January 2024

Abstract
Background
In nursing research and practice, there is a paucity of information about how fathers perceive their role in shaping their children’s health behaviors. Most studies on the parental factors affecting children’s health behaviors have focused on the role of mothers. However, recent studies showed that fathers’ health behaviors can influence those of their children. Therefore, the aim of this study was to synthesize existing qualitative studies to explore fathers’ perspectives regarding how they influence children’s obesity-related health behaviors.

Methods
We conducted a descriptive meta-synthesis. To retrieve relevant articles, we used databases including PubMed, CINAHL, and Web of Science. Only qualitative studies published in English-language peer-reviewed journals, targeting fathers of children aged 2–18 years, and focusing on fathers’ perspectives were included. All the quotes collected from the studies were reviewed and coded, and thematic analysis was used to derive themes.

Results
Article screening and review yielded a total of 13 qualitative studies, from which the following themes emerged: (1) fathers’ parenting practices and role-modeling behaviors, (2) fathers’ roles in their relationships with their family members, and (3) fathers’ resource-seeking behaviors and contributions to their home food environment. Fathers were aware that their parenting practices and role-modeling behaviors could influence their children’s health behaviors. Furthermore, fathers recognized the importance of their relationships with family members, which was reflected in their family roles; that is, whether they took responsibility for childcare and household work, whether their parenting practices were similar to those of their spouses, and whether they involved their children in their activities. Fathers also reported their resource-seeking behaviors as well as their contribution to the home food environment, which affected their children’s health behaviors.

Conclusion
Fathers’ perspectives on their influence on children’s health behaviors reveal their unique paternal role in influencing children’s health behaviors. Fathers’ perspectives could be incorporated into future nursing research to examine the relationship between fathers’ roles and children’s health behaviors to develop better health intervention programs.
Salvage treatment of acute respiratory failure after autogenous tissue flap transplantation for chronic empyema with chest wall sinus: a case report and literature review
Authors: Wang Lei , Chen Fei , He Zhongliang , He Xueming , Zhang Chun 
Published: January 2024

Abstract
Background
Chronic empyema with chest wall sinus is a difficult and complex disease caused by multiple causative factors. It is difficult to control local infection due to its possible combination of bronchopleural fistula (BPF) and residual bone.The relevant literature emphasizes some risk factors for empyema progression after pneumonectomy, while the correlation between empyema and BPF after pneumonectomy increases mortality by infecting the remaining lungs. After pneumonectomy, the lung function of the contralateral side is particularly important.

Case presentation
This paper reports a 62-year-old male patient who underwent right pneumonectomy for squamous cell carcinoma of the lung 12 years ago and began to develop empyema with anterior chest wall sinus 3 years ago. After admission, chest computed tomography (CT) showed right pleural effusion and formation of chest wall sinus. According to his clinical symptoms and imaging examination, he was diagnosed as chronic empyema with chest wall sinus.Due to the huge residual cavity of the patient,the clinical effect of using free vastus lateralis myocutaneous flap combined with pedicled pectoralis major muscle flap to fill the abscess cavity was satisfactory,but acute respiratory failure occurred due to left lung aspiration pneumonia after operation.

Conclusions
After a series of treatment measures such as tracheal cannula, tracheotomy, anti-infection, maintenance of circulatory stability, and rehabilitation training, the patient was ultimately rescued and cured. Postoperative follow-up showed that the muscle flaps survived and empyema was eliminated.
Controllability of stochastic fractional systems involving state-dependent delay and impulsive effects
Authors: Arthi G. , Vaanmathi M. , Ma Yong-Ki 
Published: January 2024

AbstractIn this paper, the controllability concept of a nonlinear fractional stochastic system involving state-dependent delay and impulsive effects is addressed by employing Caputo derivatives and Mittag-Leffler (ML) functions. Based on stochastic analysis theory, novel sufficient conditions are derived for the considered nonlinear system by utilizing Krasnoselkii’s fixed point theorem. Correspondingly, the applicability of the derived theoretical results is indicated by an example.
Evaluating the association between gingival crevicular blood glucose levels and finger capillary blood glucose levels according to periodontal status
Authors: Ansari Moghadam Somaye , Abbaszade Hanie , Sartipi Mohadeseh , Ansari Moghadam Alireza 
Published: January 2024

Abstract
Objectives
The aim of this study was to evaluate the association between gingival crevicular blood glucose levels (GCBG) and finger capillary blood glucose levels (FCBG) according to the periodontal status of patients.

Materials and methods
In this case–control study, 80 patients were divided into 4 groups according to their periodontal status. In these patients, an area of the maxillary gingiva with the highest probing depth was selected for blood sampling. Blood glucose obtained from this area and the right fingertip was measured with a glucometer. Data were analyzed using ANOVA and Pearson correlation coefficient with a significance threshold of 0.05.

Results
The groups studied were matched in regard to their sex and age (P > 0.05). The average FCBG and GCBG were not significantly different according to periodontal status (P > 0.05). The correlation between the FCBG and the GCBG showed a significant positive correlation in the total number of participants (P < 0.05, r = 0.531).

Conclusion
The study observed a positive association between GCBG and FCBG. However, the relationship with periodontal status appeared to be relatively weak. Further research may be needed to determine the potential efficacy of GCBG in diabetes screening during periodontal examinations. Clinical relevance: Most patients with diabetes do not have proper periodontal health, so it may be helpful to screen for diabetes during periodontal examinations.
Single-cell combined bioinformatics analysis: construction of immune cluster and risk prognostic model in kidney renal clear cells based on CD8+ T cell-associated genes
Authors: Gao Haifeng , Sun Hang , He Aifeng , Liu Hui , Zhang Zihang , Li Dongling , Mao Weipu , Qian Jinke 
Published: January 2024

Abstract
Background
Kidney cancer is an immunogenic solid tumor, characterized by high tumor burden and infiltration of CD8+ T cells. Although immunotherapy targeting the PD1/CTLA-4 axis has demonstrated excellent clinical efficacy, clinical outcomes in most patients are poor.

Methods
We used the RNA sequencing data from the GEO database for KIRC GSE121636 and normal kidney tissue GSE131685, and performed single-cell analysis for cluster identification, pathway enrichment, and CD8+ T cell-associated gene identification. Subsequently, the significance of different CD8+ T-cell associated gene subtypes was elucidated by consensus clustering, pathway analysis, mutated gene analysis, and KIRC immune microenvironment analysis in the TCGA–KIRC disease cohort. Single gene analysis identified LAG3 as the most critical CD8+ T-cell-associated gene and its function was verified by cell phenotype and immunohistochemistry in KIRC.

Results
In the present study, CD8+ T-cell associated genes in KIRC were screened, including GZMK, CD27, CCL4L2, FXYD2, LAG3, RGS1, CST7, DUSP4, CD8A, and TRBV20-1 and an immunological risk prognostic model was constructed (risk score =  − 0.291858656434841*GZMK − 0.192758342489394*FXYD2 + 0.625023643446193*LAG3 + 0.161324477181591*RGS1 − 0.380169045328895*DUSP4 − 0.107221347575037*TRBV20-1). LAG3 was identified and proved as the most critical CD8+ T cell-associated gene in KIRC.

Conclusion
We proposed and constructed an immunological risk prognostic model for CD8+ T cell-associated genes and identified LAG3 as a pivotal gene for KIRC progression and CD8+ T-cell infiltration. The model comprehensively explained the immune microenvironment and provided novel immune-related therapeutic targets and biomarkers in KIRC.
Investigation of community pharmacists’ knowledge and attitudes of pharmacogenomics testing: implication for improved pharmacogenomic testing practice
Authors: Ramadan Azza , Jarab Anan S. , Al Meslamani Ahmad Z. 
Published: January 2024

Abstract
Background
Community pharmacists must be well-equipped to advance pharmacogenomics services. Nevertheless, limited data is available regarding pharmacists' knowledge and attitudes toward pharmacogenomics testing. The present study aimed to evaluate community pharmacists' knowledge and attitudes toward pharmacogenomics testing in the UAE.

Methods
In this cross-sectional study, a validated, online, self-administered survey, was randomly distributed to community pharmacists across the United Arab Emirates (UAE).

Results
The participants demonstrated poor knowledge about pharmacogenomic testing (median score < 8). Having 10–29 (Adjusted odds ration [AOR]: 0.038; 95% CI: 0.01–0.146, p = 0.001) and 30–49 (AOR: 0.097; 95% CI: 0.04–0.237, p = 0.001) patients per day was associated with poorer knowledge. Also, receiving 10–29 (AOR: 0.046; 95% CI: 0.005–0.401, p = 0.005), 30–49 (AOR: 0.025; 95% CI: 0.003–0.211, p = 0.001), and > 50 (AOR: 0.049; 95% CI: 0.005–0.458, p = 0.008) prescriptions decreased the odds of having good knowledge. Around half (43.9%) of the participants did not show a positive attitude toward pharmacogenomic testing (median score < 11). Having 30–49 patients per day (AOR: 5.351; 95% CI: 2.414–11.860, p = 0.001) increased the odds of good knowledge while receiving 10–29 (AOR: 0.133; 95% CI: 0.056–0.315, p = 0.001) and 30–49 (AOR: 0.111; 95% CI: 0.049–0.252, p = 0.001) prescriptions a day were associated with decreased odds of positive attitude toward the pharmacogenomics testing.

Conclusions
The findings indicate a lack of knowledge and less-than-ideal attitudes among community pharmacists regarding pharmacogenomics testing. Enhanced efforts focused on educational initiatives and training activities related to pharmacogenomics testing is needed. Additionally, reducing workload can facilitate better knowledge acquisition and help mitigate unfavorable attitudes.
The social and environmental factors impacting the motivation of adolescents for weight control, why and how? A qualitative study
Authors: Shams Lida , Shafiei Fatemeh , Sadremomtaz Zahra 
Published: January 2024

Abstract
Introduction
Overweight and obesity are common problems among teenagers regardless of ethnicity, race, and socio-economic status. Therefore, this study aims to explore the social and environmental factors impacting adolescents motivation for weight control in Gilan province, Iran.

Methodology
Following a qualitative design, a content analysis approach was used to analyze the data. A total of 79 interviews were conducted with Adolescents (n = 23), Friends and Peers (n = 15), Parents (n = 12), Managers (n = 16), and Health care providers (n = 13), regarding adolescents obesity during 2019. MAXQDA V.10 software was used for our analysis.

Findings
The main categories of environmental and social factors affecting adolescents motivation for weight control were external factors (the relative success of weight control intervention programs, the lack of environmental and social support, and the lack of family support for teenagers) that each one had some subcategories, and internal factors (competence, relatedness, and autonomy).

Conclusion
This study demonstrated the necessity of identifying environmental and social factors that are effective in reducing adolescents’ motivation for weight loss. These factors are so influential that teenagers can’t overcome them without receiving support from their environment and the government health-related policies. So, it seems that we need integrated multisectoral approaches and we suggest that health policymakers develop practical policies to control adolescents obesity by focusing on factors that have been mentioned in this study.