bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classifying patients with psoriatic arthritis according to their disease activity status using serum metabolites and machine learning
Authors: Koussiouris John , Looby Nikita , Kotlyar Max , Kulasingam Vathany , Jurisica Igor , Chandran Vinod 
Published: January 2024

Abstract
Introduction
Psoriatic arthritis (PsA) is a heterogeneous inflammatory arthritis, affecting approximately a quarter of patients with psoriasis. Accurate assessment of disease activity is difficult. There are currently no clinically validated biomarkers to stratify PsA patients based on their disease activity, which is important for improving clinical management.

Objectives
To identify metabolites capable of classifying patients with PsA according to their disease activity.

Methods
An in-house solid-phase microextraction (SPME)—liquid chromatography-high resolution mass spectrometry (LC-HRMS) method for lipid analysis was used to analyze serum samples obtained from patients classified as having low (n = 134), moderate (n = 134) or high (n = 104) disease activity, based on psoriatic arthritis disease activity scores (PASDAS). Metabolite data were analyzed using eight machine learning methods to predict disease activity levels. Top performing methods were selected based on area under the curve (AUC) and significance.

Results
The best model for predicting high disease activity from low disease activity achieved AUC 0.818. The best model for predicting high disease activity from moderate disease activity achieved AUC 0.74. The best model for classifying low disease activity from moderate and high disease activity achieved AUC 0.765. Compounds confirmed by MS/MS validation included metabolites from diverse compound classes such as sphingolipids, phosphatidylcholines and carboxylic acids.

Conclusion
Several lipids and other metabolites when combined in classifying models predict high disease activity from both low and moderate disease activity. Lipids of key interest included lysophosphatidylcholine and sphingomyelin. Quantitative MS assays based on selected reaction monitoring, are required to quantify the candidate biomarkers identified.
Tikhonov Regularization for the Fully Coupled Integral Method of Incremental Hole-Drilling
Authors: Smit T. C. , Reid R.G. 
Published: January 2024

Abstract
Background
The unit pulse integral method is used extensively with the incremental hole-drilling residual stress measurement technique. The ASTM E837 standard, which applies only to isotropic materials, recommends the use of Tikhonov regularization to reduce instability when many depth increments are used. In its current formulation, Tikhonov regularization requires the decoupling of stress, as is possible for isotropic materials. The fully coupled integral method is needed for residual stress determination in layered composite laminates and is currently employed without Tikhonov regularization. This causes greater sensitivity to measurement errors and consequently large stress uncertainties. An approximate method of applying Tikhonov regularization exists for biaxial composites, but is not applicable to more complex laminates.

Objective
Extend Tikhonov regularization to the fully coupled integral method to improve residual stress determination in composite laminates.

Methods
This work investigates the use of the approximate and fully coupled regularization approaches in an angle ply composite laminate of [+45/-45/0/90]s construction. Experimental validation in a [0/+45/90/-45]s laminate is also presented where the regularized fully coupled integral method is compared to the series expansion method that includes all in-plane stress and strain directions simultaneously in a least-squares solution.

Results
The regularized integral method produces comparable results to those of series expansion while requiring twelve times less FE computation to calculate the compliances. The optimal degree of regularization is also more convenient to determine than the optimal combination of series order required by series expansion.

Conclusions
The new method is easily applied and should find wide application in the measurement of residual stresses in composite laminates.
Anaphylaxis as probable cause of death in a rare case of fatal Vipera berus bite
Authors: Mittendorf Anton F. , Winskog Carl 
Published: January 2024

Abstract
This case report describes the death of a 52-year-old male who was bitten by a venomous snake, Vipera berus (common European adder), on his left wrist. Despite experiencing symptoms, the patient refused medical care and self-medicated with alcohol instead. He was later found dead in his residence. Autopsy and histological examination revealed evidence of an anaphylactic reaction in response to the snake bite, with additional findings of alcohol intoxication and other underlying medical conditions.
A post-emergence herbicide program for weedy sunflower (Helianthus annuus L.) control in maize
Authors: Brankov Milan , Simić Milena , Piskackova Theresa , Zarić Miloš , Rajković Miloš , Pavlović Natalija , Dragičević Vesna 
Published: January 2024

AbstractDuring the last 15 years in Serbia, there has been an invasion of H. annuus across the country. Plants were initially limited to non-cultivated areas near arable fields, while in recent years the species has started to occur and establish populations in crop fields, especially into wide-row crops. We tested eight herbicides in two greenhouse experiments: 1) a dose-response study; 2) an efficacy study with reduced herbicide rates adding an adjuvant. The tested herbicides showed satisfactory weed control, where all estimated effective doses 90 (ED90) were lower than the recommended field rate for each herbicide, except for dicamba. The addition of non-ionic surfactants significantly increased the efficacy of glyphosate, mesotrione, rimsulfuron, and foramsulfuron. Whereas, there was no clear advantage to adding an adjuvant to bentazone and tembotrione, as the H. annuus population was already very sensitive (plants died in 1/8 of recommended rate in a dose-response study). All tested herbicides, except dicamba, can be used for satisfactory H. annuus control in maize, while glyphosate can be used for control of the species in non-agricultural lands.
On smooth functions with two critical values
Authors: Lerario Antonio , Meroni Chiara , Zuddas Daniele 
Published: January 2024

AbstractWe prove that every smooth closed connected manifold admits a smooth real-valued function with only two critical values such that the set of minima (or maxima) can be arbitrarily prescribed, as soon as this set is a finite subcomplex of the manifold (we call a function of this type a Reeb function). In analogy with Reeb’s Sphere Theorem, we use such functions to study the topology of the underlying manifold. In dimension 3, we give a characterization of manifolds having a Heegaard splitting of genus g in terms of the existence of certain Reeb functions. Similar results are proved in dimension $$n\ge 5$$

n
≥
5

.
Bacterial contamination of air and surfaces during dental procedures—An experimental pilot study using Staphylococcus aureus
Authors: Franz Jessica , Scheier Thomas C. , Aerni Maja , Gubler Andrea , Schreiber Peter W. , Brugger Silvio D. , Schmidlin Patrick R. 
Published: January 2024

AbstractObjective:The oral cavity contains numerous microorganisms, including antimicrobial-resistant bacteria. These microorganisms can be transmitted via respiratory particles from patients to healthcare providers and vice versa during dental care. We evaluated the spread of Staphylococcus aureus during standardized dental procedures using different scaling devices and rinsing solutions.Methods:During systematic therapy for dental biofilm removal (guided biofilm therapy), using an airflow or ultrasound device to a model simulation head. Staphylococcus aureus suspension was injected into the mouth of the model to mimic saliva. Different suction devices (conventional saliva ejector or a prototype) and rising solutions (water or chlorhexidine) were used. To assess contamination with S. aureus, an air-sampling device was placed near the oral cavity and samples of surface areas were collected.Results:S. aureus was only detected by air sampling when the conventional saliva ejector with airflow was used. No growth was observed during treatments with the ultrasonic piezo instrument or the prototype suction device. Notably, a rinsing solution of chlorhexidine digluconate decreased the bacterial load compared to water. Surface contamination was rarely detected (1 of 120 samples).Conclusions:Although our findings indicate potential airborne bacterial transmission during routine prophylactic procedures, specific treatment options during biofilm removal appear to reduce air contamination. These options include ultrasonic piezo devices or the prototype suction device. The use of chlorhexidine reduced the CFU counts of S. aureus detected by air sampling. Surface contamination during dental procedures was a rare occurrence.
Choosing, rejecting, and closely replicating, 30 years later: A commentary on Chandrashekar et al.
Authors: Shafir Eldar , Cheek Nathan N. 
Published: January 2024

Abstract
In a ‘very close replication’ study using the same attributes as the original, Chandrashekar et al. (2021) report a failure to replicate some choose–reject problems documented in Shafir (1993). We find that several of the original attributes have changed their valence three decades later, and we compose new versions with updated attributes that fully replicate Shafir’s (1993) original findings. Despite their apparent exactitude, ‘very close replications’ across contexts or time, when stimuli may have changed their meaning or valence, can be highly misleading, further exacerbating replication concerns.
Enterococcus contamination of infant foods and implications for exposure to foodborne pathogens in peri-urban neighbourhoods of Kisumu, Kenya
Authors: Gutema Fanta D. , Cumming Oliver , Mumma Jane , Simiyu Sheillah , Attitwa Edwin , Okoth Bonphace , Denge John , Sewell Daniel , Baker Kelly K. 
Published: January 2024

Abstract
We collected infant food samples from 714 households in Kisumu, Kenya, and estimated the prevalence and concentration of Enterococcus, an indicator of food hygiene conditions. In a subset of 212 households, we quantified the change in concentration in stored food between a morning and afternoon feeding time. In addition, household socioeconomic characteristics and hygiene practices of the caregivers were documented. The prevalence of Enterococcus in infant foods was 50% (95% confidence interval: 46.1 - 53.4), and the mean log10 colony-forming units (CFUs) was 1.1 (SD + 1.4). No risk factors were significantly associated with the prevalence and concentration of Enterococcus in infant foods. The mean log10 CFU of Enterococcus concentration was 0.47 in the morning and 0.73 in the afternoon foods with a 0.64 log10 mean increase in matched samples during storage. Although no factors were statistically associated with the prevalence and the concentration of Enterococcus in infant foods, household flooring type was significantly associated with an increase in concentration during storage, with finished floors leading to 1.5 times higher odds of concentration increase compared to unfinished floors. Our study revealed high prevalence but low concentration of Enterococcus in infant food in low-income Kisumu households, although concentrations increased during storage implying potential increases in risk of exposure to foodborne pathogens over a day. Further studies aiming at investigating contamination of infant foods with pathogenic organisms and identifying effective mitigation measures are required to ensure infant food safety.
A systematic review of AI-based automated written feedback research
Authors: Shi Huawei , Aryadoust Vahid 
Published: January 2024

AbstractIn recent years, automated written feedback (AWF) has gained popularity in language learning and teaching as a form of artificial intelligence (AI). The present study aimed at providing a comprehensive state-of-the-art review of AWF. Using Scopus as the main database, we identified 83 SSCI-indexed published articles on AWF (1993–2022). We investigated several main domains consisting of research contexts, AWF systems, feedback focus, ways of utilizing AWF, research design, foci of investigation, and results. Our results showed that although AWF was primarily studied in language and writing classes at the tertiary level, with a focus on English as the target language, the scope of AWF research has been steadily broadening to include diverse language environments and ecological settings. This heterogeneity was also demonstrated by the wide range of AWF systems employed (n = 31), ways of integrating AWF (n = 14), different types of AWF examined (n = 3), as well as varied research designs. In addition, three main foci of investigation were delineated: (1) the performance of AWF; (2) perceptions, uses, engagement with AWF, and influencing factors; and (3) the impact of AWF. We identified positive, negative, neutral, and mixed results in all three main foci of investigation. Overall, less positive results were found in validating AWF compared to results favoring the other two areas. Lastly, we grounded our findings within the argument-based validity framework and also examined the potential implications.
Discrepancies between self- and informant-ratings of functional abilities and objective cognition: predictors of bias in mild cognitive impairment
Authors: De Wit Liselotte , Goldstein Felicia C. , Saurman Jessica L. , Rodriguez Amy D. , Vickers Kayci L. 
Published: January 2024

AbstractObjective:Self- and informant-ratings of functional abilities are used to diagnose mild cognitive impairment (MCI) and are commonly measured in clinical trials. Ratings are assumed to be accurate, yet they are subject to biases. Biases in self-ratings have been found in individuals with dementia who are older and more depressed and in caregivers with higher distress, burden, and education. This study aimed to extend prior findings using an objective approach to identify determinants of bias in ratings.Method:Participants were 118 individuals with MCI and their informants. Three discrepancy variables were generated including the discrepancies between (1) self- and informant-rated functional status, (2) informant-rated functional status and objective cognition (in those with MCI), and (3) self-rated functional status and objective cognition. These variables served as dependent variables in forward linear regression models, with demographics, stress, burden, depression, and self-efficacy as predictors.Results:Informants with higher stress rated individuals with MCI as having worse functional abilities relative to objective cognition. Individuals with MCI with worse self-efficacy rated their functional abilities as being worse compared to objective cognition. Informant-ratings were worse than self-ratings for informants with higher stress and individuals with MCI with higher self-efficacy.Conclusion:This study highlights biases in subjective ratings of functional abilities in MCI. The risk for relative underreporting of functional abilities by individuals with higher stress levels aligns with previous research. Bias in individuals with MCI with higher self-efficacy may be due to anosognosia. Findings have implications for the use of subjective ratings for diagnostic purposes and as outcome measures.
Communicating with families of young people with hard-to-treat cancers: Healthcare professionals’ perspectives on challenges, skills, and training
Authors: Kelada Lauren , Robertson Eden G. , McKay Skye , McGill Brittany C. , Daly Rebecca , Mazariego Carolyn , Taylor Natalie , Tyedmers Elijah , Armitage Nicole , Evans Holly E. , Wakefield Claire E. , Ziegler David S. 
Published: January 2024

AbstractObjectivesHard-to-treat childhood cancers are those where standard treatment options do not exist and the prognosis is poor. Healthcare professionals (HCPs) are responsible for communicating with families about prognosis and complex experimental treatments. We aimed to identify HCPs’ key challenges and skills required when communicating with families about hard-to-treat cancers and their perceptions of communication-related training.MethodsWe interviewed Australian HCPs who had direct responsibilities in managing children/adolescents with hard-to-treat cancer within the past 24 months. Interviews were analyzed using qualitative content analysis.ResultsWe interviewed 10 oncologists, 7 nurses, and 3 social workers. HCPs identified several challenges for communication with families including: balancing information provision while maintaining realistic hope; managing their own uncertainty; and nurses and social workers being underutilized during conversations with families, despite widespread preferences for multidisciplinary teamwork. HCPs perceived that making themselves available to families, empowering them to ask questions, and repeating information helped to establish and maintain trusting relationships with families. Half the HCPs reported receiving no formal training for communicating prognosis and treatment options with families of children with hard-to-treat cancers. Nurses, social workers, and less experienced oncologists supported the development of communication training resources, more so than more experienced oncologists.Significance of resultsResources are needed which support HCPs to communicate with families of children with hard-to-treat cancers. Such resources may be particularly beneficial for junior oncologists and other HCPs during their training, and they should aim to prepare them for common challenges and foster greater multidisciplinary collaboration.
The Thunderstorms With the Greatest Lightning Densities on Earth
Authors: Peterson Michael 
Published: January 2024

AbstractThe most intense thunderstorms on Earth were surveyed using the comprehensive meteorological instrumentation on the Tropical Rainfall Measuring Mission (TRMM) satellite. Expansive land‐based Mesoscale Convective Systems (MCSs) were consistently identified among the Earth's most intense thunderstorms, with their organization into many convective cells spanning a large areal extent permitting exceptional overall flash rates for these storms. In this study, we identify a new class of extreme thunderstorm. Lightning‐dense thunderstorms are relatively compact convective storms whose concentrated lightning activity hinders our ability to accurately measure their flash rates. The top storms have a flash rate of one flash spanning many seconds, as there is insufficient separation to distinguish one flash from another. While any particularly active convective cell could be capable of producing high lightning densities, we find that thunderstorms with the greatest lightning densities on Earth are found in maritime thunderstorms that have not been appreciated in prior work due to the inaccurate flash rate measurements. These storms that are mostly found throughout the Gulf of Mexico and east of South Africa (among other coastal and oceanic regions) have measured TRMM proxies for convective intensity that rival the top MCS thunderstorms, but their horizontal and vertical dimensions are small by comparison. Thus, the necessary microphysical elements for electrification processes are more highly concentrated, enabling the observed extreme lightning densities.
Waterborne Virus Transport and Risk Assessment in Lake Geneva Under Climate Change
Authors: Li Chaojie , Kohn Tamar 
Published: January 2024

AbstractClimate changes influence lake hydrodynamics and radiation levels and thus may affect the fate and transport of waterborne pathogens in lakes. This study examines the impact of climate change on the fate, transport, and associated risks of four waterborne viruses in Lake Geneva. We used a coupled water quality‐microbial risk assessment model to estimate virus concentrations and associated risks to recreational water users for each month in 2019 and 2060. Long‐term hydrodynamic simulations suggested that although the annual hydrodynamic transport pattern of Lake Geneva will remain relatively stable, a 1.9°C increase of lake surface water temperature can be expected, while a slight decrease in lake current velocity may occur. The subsequent effect on the fate and transport of the four enteric viruses was found to vary by time of year. During warmer periods, the increase of virus inactivation due to higher water temperature and stronger solar radiation at the earth's surface will compensate for the additional virus discharge brought about by population growth over the time period considered, whereas during winter the virus concentration near the lake shore and the associated infection probabilities risks are likely to increase due to population growth. Additionally, the current estimation of virus inactivation rate shows significant variability, which has a more substantial effect on enteric virus concentrations in the lake compared with changing climate parameters. Overall, the study suggests that future risks posed by enteric viruses with recreational water users near popular beaches around Lake Geneva will likely remain similar to current risks and accurate estimation of the environmental inactivation of viruses is crucial for predicting the fate of enteric viruses in the aquatic system.
Urbanization Amplified Compound Hot Extremes Over the Three Major Urban Agglomerations in China
Authors: Lin Xin , Wang Yujie , Song Lianchun 
Published: January 2024

AbstractUnderstanding how urbanization affects compound hot extremes (CHEs) is important for the sustainable development in urban agglomeration under global warming. In this study, we investigate the changes of CHEs in summer over the Beijing‐Tianjin‐Hebei region (BTH), Yangtze River Delta (YRD) and Pearl River Delta (PRD) in China, and assess the effects of urbanization on these changes. We find that the frequency and intensity of CHEs in summer show significantly increasing trends in these agglomerations in the recent five decades, particularly in megacities such as Beijing, Shanghai, Guangzhou and Tianjin. The urbanization contributions to CHEs in the YRD and PRD were estimated to 36 ∼ 58%, while relatively small in the BTH, ranging 16 ∼ 29%. They were bonded to the unban size, expansion speed and local climate. In addition to global warming and urbanization, the strengthening continental high and enhancing Western Pacific Subtropical High and its westward displacement were favor to the increased CHEs.
Prediction of Ionograms With/Without Spread‐F at Hainan by a Combined Spatio‐Temporal Neural Network
Authors: Gao Pengdong , Cai Jinhui , Wang Zheng , Qiu Chu , Wang Guojun , Qi Quan , Wang Bo , Shi Jiankui , Wang Xiao , Ding Kai 
Published: January 2024

AbstractAn intelligent high‐definition and short‐term prediction of ionograms with/without Spread‐F for the observation at Hainan (19.5°N, 109.1°E, magnetic 11°N) is presented in this paper, which comprises a spatio‐temporal ConvGRU network and a super‐resolution EDSR network. Our prediction is based on spatio‐temporal features in the ionogram graph only. There are 469,227 ionograms classified into 5 categories, that is, frequency/range/mix/strong range/no Spread F, over a solar cycle (14 years) labeled manually by the research group, and we process these ionograms into two data sets for training the two networks mentioned above. A series of comprehensive experiments have been designed and conducted to determine the optimal super‐parameters. Our method inputs 8 consecutive authentic ionograms (lasting 2 hr) and generates the next 2 figures (next 30 min). Remarkably, all predicted figures achieve a high accuracy rate of over 94% in predicting the occurrence of Spread‐F.