bluuebunny/crossref_metadata_2025_split huggingface dataset:
DO WE NEED LAMINAR FLOW IN TRAUMA?
Authors: Lewandowski D. , Hussein A. , Matthew A. , Ahuja S. 
Published: January 2024

Laminar flow theatres were first introduced in the United Kingdom in the 1960s and 1970s and have become standard in orthopaedic surgery involving implants. A study from 1982 showed a 50% reduction in infections with joint arthroplasties when compared to conventional theatres and laminar flow became standard in the following decades. Recent evidence including a meta-analysis from 2017 questions the effectiveness of these theatre systems. Most of the evidence for Laminar flow use is based on arthroplasty surgery. We aimed to determine the effect of using non-laminar flow theatres on our trauma patients.A total of 1809 patients who had trauma surgery were identified from 2019 to 2021. 917 patients were operated on in a laminar theatre and 892 in a non-laminar theatre across two operating sites. We identified the surgical site infections as reported through our surveillance program within the first 90 days of infection. Patient co-morbidities were noted through patient records and procedure length was also noted.Of the 1809 trauma patients identified between the years of 2019 and 2021, 917 patients had operations in a laminar flow theatre and 892 in a non-laminar theatre. Of the 892 operated in non-laminar flow theatres, 543 were operated in the University Hospital of Wales (UHW) and 349 at the University Hospital of Llandough (UHL). An analysis of soft tissue infections and hospital acquired infections post-operatively demonstrated 15/543 and 71/543 respectively for non-laminar UHW infections and 4/349 and 21/349 for non-laminar UHL infections. A look at laminar flow patients showed 25/917 with soft tissue infections and 86/917 hospital acquired infections. There was no difference between laminar and non-laminar flow theatre infection rates showing rates of 12.1% and 12.2% respectively.In our trauma patients we noticed no significant advantage of using laminar flow theatres when compared to non-laminar flow theatres. This is in keeping with some recently published literature. Laminar flow theatres have been shown to decrease airborne pathogen counts under controlled conditions, but we conclude in the day to day environment of trauma theatres these conditions are either not met or that the theoretical advantage of laminar flow does not translate to a direct advantage of reduction of infections which may be achieved by standard prophylactic antibiotics.
OUTCOME OF TREATMENT FOLLOWING PRIMARY ARTHROSCOPIC REPAIR OF BUCKET HANDLE MENISCUS TEARS IN ADULTS
Authors: Nanjundaiah R. , Guro R. , Chandratreya A. , Kotwal R. 
Published: January 2024

AimsWe studied the outcomes following arthroscopic primary repair of bucket handle meniscus tears to determine the incidence of re-tears and the functional outcomes of these patients.MethodologyProspective cohort study. Over a 4-year period (2016 to 2020), 35 adult patients presented with a bucket handle tear of the meniscus. Arthroscopic meniscal repair was performed using either the all inside technique or a combination of all-inside and inside-out techniques. 15 patients also underwent simultaneous arthroscopic anterior cruciate ligament reconstruction. Functional knee scores were assessed using IKDC and Lysholm scores.ResultsMean patient age at surgery was 27 years (range, 17 to 53years). Medial meniscus was torn in 20 and lateral in 15 cases. Zone of tear was white on white in 19, red on white in 9 and red on red in 7 cases. Average delay from injury to surgery was 4 months. At a mean follow-up of 4.5 years, the meniscus repair failed in 3 patients (8.5 %). Outcome following re-tear was meniscus excision. Average IKDC scores in patients with intact repair were 74.04 against 56.67 in patients with a failed repair (p< 0.0001). Similarly, Lyshlom scores were 88.96 and 67.333, respectively (p<0.0001).ConclusionThe survivorship of primary repair of bucket handle meniscus tears in our series was 91.5% at medium term follow-up. Functional outcomes were significantly poor in patients with a failed repair compared to those with an intact repair.
A NOVEL 3D-PRINTED DUAL-MOBILITY IMPLANT: RESULTS UP TO SEVEN YEARS IN CLINICAL PRACTICE
Authors: Raj S. , Magan A. , Jones S. A. 
Published: January 2024

Dual mobility (DM) is an established bearing option in Total Hip Arthroplasty (THA). The traditional mono-block DM designs have limited ability for additional fixation, whereas the modular DM designs allow additional screw fixation but limit internal diameter and have the potential to generate metal debris. We report the early results of a CoCrMo alloy mono-block implant manufactured by additive technology with a highly porous ingrowth surface to enhance primary fixation and osseointegration.Prospective follow-up of the DuplexTM implant first inserted in March 2016 enrolled into Beyond Compliance (BC). Primary outcome measure was all-cause revision and secondary outcomes dislocation, peri-prosthetic fracture (PPF) and Oxford Hip Score (OHS). Patients were risk stratified and all considered to be high risk for instability. Complications were identified via hospital records, clinical coding linkage using national database and via BC website.159 implants in 154 patients with a mean age 74.0 years and a maximum F/U of 7 years. Survivorship for all-cause revision 99.4% (95% CI 96.2–99.8). One femoral only revision. Mean gain in OHS 27.4. Dislocation rate 0.6% with a single event. Patients with a cemented Polished taper stem (PTS) had a Type B PPF rate of 2.1% requiring revision/fixation. Compared to conventional THA this cohort was significantly older (74.0 vs 68.3 years), more co-morbidity (ASA 3 46.5% vs 14.4%) and more non-OA indications (32.4% vs 8.5%). Every patient had at least one risk factor for falling and >50% of cohort had 4 or more risk factors using NICE tool.We believe our results demonstrate that risk stratification successfully aids implant selection to prevent dislocation in high-risk patients. This novel design has provided excellent early results in a challenging cohort where individuals are very different to the “average” THA patient. NJR data on DM has reported an increase in revision for PPF. A “perfect storm” maybe created using DM in high-risk falls risk population. This re-enforces the need to consider all patient and implant factors when deciding bearing selection.
ACCORD (ACcurate COnsensus Reporting Document): A reporting guideline for consensus methods in biomedicine developed via a modified Delphi
Authors: Gattrell William T. , Logullo Patricia , van Zuuren Esther J. , Price Amy , Hughes Ellen L. , Blazey Paul , Winchester Christopher C. , Tovey David , Goldman Keith , Hungin Amrit Pali , Harrison Niall 
Published: January 2024

Background
In biomedical research, it is often desirable to seek consensus among individuals who have differing perspectives and experience. This is important when evidence is emerging, inconsistent, limited, or absent. Even when research evidence is abundant, clinical recommendations, policy decisions, and priority-setting may still require agreement from multiple, sometimes ideologically opposed parties. Despite their prominence and influence on key decisions, consensus methods are often poorly reported. Our aim was to develop the first reporting guideline dedicated to and applicable to all consensus methods used in biomedical research regardless of the objective of the consensus process, called ACCORD (ACcurate COnsensus Reporting Document).

Methods and findings
We followed methodology recommended by the EQUATOR Network for the development of reporting guidelines: a systematic review was followed by a Delphi process and meetings to finalize the ACCORD checklist. The preliminary checklist was drawn from the systematic review of existing literature on the quality of reporting of consensus methods and suggestions from the Steering Committee. A Delphi panel (n = 72) was recruited with representation from 6 continents and a broad range of experience, including clinical, research, policy, and patient perspectives. The 3 rounds of the Delphi process were completed by 58, 54, and 51 panelists. The preliminary checklist of 56 items was refined to a final checklist of 35 items relating to the article title (n = 1), introduction (n = 3), methods (n = 21), results (n = 5), discussion (n = 2), and other information (n = 3).

Conclusions
The ACCORD checklist is the first reporting guideline applicable to all consensus-based studies. It will support authors in writing accurate, detailed manuscripts, thereby improving the completeness and transparency of reporting and providing readers with clarity regarding the methods used to reach agreement. Furthermore, the checklist will make the rigor of the consensus methods used to guide the recommendations clear for readers. Reporting consensus studies with greater clarity and transparency may enhance trust in the recommendations made by consensus panels.
Components of effective letters of recommendation: A cross-sectional survey of academic faculty
Authors: Ibrahim Halah , Mohamad Mohamad Kasem , Elhag Shahad Abasaeed , Al-Habbal Khairat , Harhara Thana , Shehadeh Mustafa , Oyoun Alsoud Leen , Abdel-Razig Sawsan 
Published: January 2024

Introduction
Conventional merit-based criteria, including standardized test scores and grade point averages, have become less available to residency programs to help distinguish applicants, making other components of the application, including letters of recommendation (LORs), important surrogate markers for performance. Despite their impact on applications, there is limited published data on LORs in the international setting.

Methods
A cross-sectional survey of academic faculty was conducted between 9 January 2023 and 12 March 2023 at two large academic medical centers in the United Arab Emirates. Descriptive statistics were used to tabulate variable frequencies.

Results
Of the 98 respondents, the majority were male (n = 67; 68.4%), Western-trained (n = 66; 67.3%), mid-career physicians (n = 46; 46.9%). Most respondents (n = 77; 78.6%) believed that the purpose of an LOR was to help an applicant match into their desired program. Letters rarely included important skills, such as leadership (n = 37; 37.8%), applicant involvement in research (n = 43; 43.9%), education (n = 38; 38.8%), or patient advocacy (n = 30; 30.6%). Most faculty (n = 81; 82.7%) were not familiar with standardized letters of recommendation. Only 7.3% (n = 7) of respondents previously received training in writing LORs, but 87.7% (n = 86) expressed an interest in this professional development opportunity.

Conclusion
There is variability in perceptions and practices related to LOR writing in our international setting, with several areas for improvement. Given the increasing importance of LORs to a candidate’s application, faculty development is necessary.
The EU Migrant Generation in Asia: Middle-Class Aspirations in Asian Global Cities, Helena Hof (2022)
Authors: Cranston Sophie 
Published: January 2024

Review of: The EU Migrant Generation in Asia: Middle-Class Aspirations in Asian Global Cities, Helena Hof (2022)
Bristol: Bristol University Press, 264 pp.,
ISBN 978-1-52922-500-6, p/bk, £80
Moving Figures and Grounds in music description
Authors: Wadley Phillip , Tenbrink Thora , Wallington Alan 
Published: January 2024

Abstract
This paper is a systematic investigation of motion expressions in programmatic music description. To address issues with defining the Source MOTION and the Target MUSIC, we utilize Gestalt models (Figure-Ground and Source-Path-Goal) while also critically examining the ontological complexity of the Target MUSIC. We also investigate music motion descriptions considering the role of the describer’s perspective and communicative goals. As previous research has demonstrated, an attentional Goal-bias is common in physical motion description, yet this has been found also to lessen due to audience accommodation effects. We investigate whether this also occurs in music description. Using cognitive linguistic frameworks, we conducted an analysis of 21 English speakers’ written descriptions of dynamic orchestral excerpts. All participants gave a description of one excerpt reporting their own personal experiences and the other excerpt reporting the events of the excerpt for a fictional future participant. We find that addressee accommodation shapes the choice of the ontological types of Figures used from being more subjective and creative in describing music for oneself versus being more objective in describing music for others. However, our investigation does not find sufficient evidence for a Goal-bias in music like there is in physical motion event descriptions.
Application of finite element method in industrial design, example of an electric motorcycle design project
Authors: Graba Marcin , Grycz Andrzej 
Published: January 2024

Abstract
This study presents the use of finite element method (FEM) in solving the real engineering problems, e.g., an electric motorcycle design project. A simplified scheme of industrial design is presented, followed by an indication of how to use the capabilities of the selected CAD/CAM/ CAE software in the industrial design of industrial form. Using concurrent design based on the CAD system with the simultaneous use of CAE modules, the interdisciplinary of industrial design engineering was shown, which cannot exist without access to numerical methods. In the electric motorcycle project discussed in this article, the close relation between CAD and CAE modules was used, looking for the best solution in the construction of the motorcycle frame. By conducting a series of numerical simulations based on the FEM and topological optimization, the final shape of the frame and the rear control arm mounting was presented. The designed structure was optimized in terms of mass and effective stress distributions determined from the Huber-Mises-Hencky hypothesis. The resulting model of the frame was adapted to the design project, briefly discussed in the summary of the article. This study indicates the need to use the FEM and CAD/CAM/CAE applications at almost every stage of engineering design.
Theoretical magnetotelluric response of stratiform earth consisting of alternative homogeneous and transitional layers
Authors: Miao Hongzhi , Ming Huifang , Xiao Xuelu , Dai Bolan , Yang Xiaowei 
Published: January 2024

Abstract
The magnetotelluric (MT) responses are explicitly solved for a stratiform earth containing multiple transitional layers in which the conductivity varies linearly with depth. In the model under consideration, any one homogeneous layer with constant conductivity or transitional one may be absent in the geometry. The traditional one-dimensional (1D) models with sharp boundaries will be obtained if all the transitional layers are absent in the geometry, while a special 1D model consisting of a sequence of contiguous transitional layers may be obtained if all the homogeneous layers (except the basement layer) are removed from the geometry. The tangential electric and magnetic fields as well as the surface impedance are analytically expressed by Airy functions. The analytical formula is validated in three theoretical examples by comparing with the results from available codes. The apparent resistivity and impedance phase on the surface of three different transitional models are illustrated to analysis the influence of the transitional layers on MT responses. The new formula provides an alternative way to obtain the analytic MT responses for the special layered earth.
TIF1γ and SMAD4 regulation in colorectal cancer: impact on cell proliferation and liver metastasis
Authors: Wu Yanhui , Yu Bin , Ai Xi , Zhang Wei , Chen Weixun , Laurence Arian , Zhang Mingzhi , Chen Qian , Shao Yajie , Zhang Bixiang 
Published: January 2024

Abstract
We investigated the effects of transcriptional intermediary factor 1γ (TIF1γ) and SMAD4 on the proliferation and liver metastasis of colorectal cancer (CRC) cells through knockdown of TIF1γ and/or SMAD4 and knockdown of TIF1γ and/or restoration of SMAD4 expression. Furthermore, we examined TIF1γ and SMAD4 expression in human primary CRC and corresponding liver metastatic CRC specimens. TIF1γ promoted but SMAD4 inhibited the proliferation of CRC cells by competitively binding to activated SMAD2/SMAD3 complexes and then reversely regulating c-Myc, p21, p27, and cyclinA2 levels. Surprisingly, both TIF1γ and SMAD4 reduced the liver metastasis of all studied CRC cell lines via inhibition of MEK/ERK pathway-mediated COX-2, Nm23, uPA, and MMP9 expression. In patients with advanced CRC, reduced TIF1γ or SMAD4 expression was correlated with increased invasion and liver metastasis and was a significant, independent risk factor for recurrence and survival after radical resection. Patients with advanced CRC with reduced TIF1γ or SAMD4 expression had higher recurrence rates and shorter overall survival. TIF1γ and SMAD4 competitively exert contrasting effects on cell proliferation but act complementarily to suppress the liver metastasis of CRC via MEK/ERK pathway inhibition. Thus, reduced TIF1γ or SMAD4 expression in advanced CRC predicts earlier liver metastasis and poor prognosis.
Diversity in osteopathic medical school admissions and the COMPASS program: an update
Authors: Dady Nadege , Toplan Steven , Gardere Jeffrey , Moore Robin , Agandi Lorreen , Ulysse Ulcha Fergie , Aminpour Aida , Gelvin McKensie , Akinsanya Jemima , Steier Kenneth 
Published: January 2024

Abstract
In the United States, the 40 colleges of osteopathic medicine and 157 schools of allopathic medicine face challenges in recruiting candidates who are underrepresented in medicine (URiM), and gaps in racial disparity appear to be widening. In this commentary, the authors provide an analysis of the data collected from 8 years of conducting a URiM recruitment and welcoming social events. The event is sponsored by a student special interest group called Creating Osteopathic Minority Physicians Who Achieve Scholastic Success (COMPASS) at the Touro College of Osteopathic Medicine – New York (TouroCOM-NY). The results of the 8-year data analysis supports the conclusion that the COMPASS program has benefited the school environment through increased diversity.
Enhancement of mechanical strength of miter joints in pultruded fiberglass/epoxy composite
Authors: Isguzar Tugce , Turan Fatih , Sakman Lutfi Emir 
Published: January 2024

Abstract
In this research, we experimentally investigated how the shape of fittings affects the load-carrying capacity of miter joints in pultruded glass/epoxy composite frames. Specifically, three types of steel fittings – dovetail (D-shaped), H-shaped, and rectangular (U-shaped) were utilized to reinforce the miter joints in composite frames. Tension and compression tests were performed to assess the load-carrying capacity of these joint configurations. Additionally, finite element analysis (FEA) was employed to examine stress distribution patterns within the joint configurations, allowing us to make comparisons among the joint configurations in terms of their strength. The findings of the study demonstrated that all types of joint configurations successfully improved the joint strength, regardless of whether they were subjected to tensile or compressive loading conditions. Notably, H and D type steel fittings exhibited superior effectiveness in strengthening the adhesive miter joints when compared to U type steel fittings, particularly in tensile loading scenarios. Moreover, all types of steel fittings displayed promise as viable options for enhancing joint strength in compressive loading situations.
BMAL1 positively correlates with genes regulating steroidogenesis in human luteinized granulosa cells
Authors: Kawamura Tomomi , Dai Yidan , Ono Masanori , Kikuchi Takayuki , Yamanaka Akina , Ueno Keiko , Kojima Junya , Fujiwara Tomoko , Daikoku Takiko , Maida Yoshiko , Ando Hitoshi , Fujiwara Hiroshi , Kuji Naoaki , Nishi Hirotaka 
Published: January 2024

In brief
In this study, we examined the relationship between BMAL1 expression and the genes regulating steroid biosynthesis in human luteinized granulosa cells. BMAL1 function is crucial for steroid production and proper ovarian function, highlighting the importance of circadian clock regulation in female reproductive health.

Abstract
Human luteinized granulosa cells were collected to analyze circadian clock gene expression and its effect on the genes regulating steroid biosynthesis. We used siRNA to knock down the expression of BMAL1 in KGN cells. We measured the expression levels of genes regulating steroid biosynthesis and circadian clock RT-qPCR. We demonstrated that BMAL1 expression positively correlates with genes regulating steroid biosynthesis (CYP11A1, CYP19A1, STAR, and ESR2). The knockdown of BMAL1 in KGN cells revealed a significant decrease in steroid synthase expression. In contrast, when BMAL1 was overexpressed in KGN and HGL5 cells, we observed a significant increase in the expression of steroid synthases, such as CYP11A1 and CYP19A1. These results indicated that BMAL1 positively controls 17β-estradiol (E2) secretion in granulosa cells. We also demonstrated that dexamethasone synchronization in KGN cells enhanced the rhythmic alterations in circadian clock genes. Our study suggests that BMAL1 plays a critical role in steroid biosynthesis in human luteinized granulosa cells, thereby emphasizing the importance of BMAL1 in the regulation of reproductive physiology.
Therapeutic results in children with brain tumors – a single center experience over 18 years
Authors: Cosnarovici Maria Margareta , Cosnarovici Rodica , Piciu Doina 
Published: January 2024

Background and aims. Tumors of the central nervous system represent the main cause of death by cancer in children. The diagnosis and molecular classification of these neoplasms have seen great improvement in the past years, due to ongoing genomic advances. In general, the treatment consists of surgery, radiation therapy and chemotherapy. However, the currently available pharmacological treatment options have limited effectiveness due to the particular characteristics of the blood-brain barrier.
Methods. We decided to study the therapeutic results in children treated for brain tumors in the Cluj-Napoca “Prof. dr. Ion Chiricuta” Oncology Institute, between 2001 and 2018, in order to provide a more accurate understanding of the disease and the available therapeutic options in our center.
Results. Out of the 207 cases included in this study, we recorded 98 deaths (47.3%). This is significantly less than the 5-year survival rate recorded in the US between 2012 and 2018 (74.9%). There are many factors that could explain the low survival rate, such as a very late diagnosis, the inability to implement innovative radiation therapy techniques until 2018, and the fact that between 2001 and 2010 the chemotherapy regimens in our center were not as effective as the more recent ones.
Conclusions. The therapeutic results recorded in this study are similar to those in other middle-income countries, however, the available treatment options for pediatric brain tumors are not as effective as those currently in use for other pediatric and adult malignancies.