bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of cigarette smoking on retinal thickness and choroidal vascularity index: a systematic review and meta-analysis
Authors: Quiroz-Reyes Miguel A. , Quiroz-Gonzalez Erick A. , Quiroz-Gonzalez Miguel A. , Lima-Gomez Virgilio 
Published: February 2025

Abstract

Background
Smoking increases oxidative stress, affecting the vascular endothelium by decreasing the antioxidant vitamin C and disrupting regular nitric oxide activity. It reduces blood flow in the retina and choroid due to increased vascular resistance and compromised choroidal blood flow regulation compared to nonsmokers. This systematic review and meta-analysis aimed to elucidate the impact of cigarette smoking on retinal thickness and the choroidal vascularity index (CVI).

Methods
A comprehensive literature search was performed across multiple databases, including Web of Science, Medline, PubMed, and Embase, adhering to the PRISMA and MOOSE guidelines. Observational studies were selected to explore the relationships between smoking and ocular parameters such as CVI, full-retinal, and choroidal thickness. Two independent reviewers conducted the data extraction and quality assessment using a modified Newcastle–Ottawa scale. Statistical analysis was performed using a random-effects model.

Results
Four out of the 743 identified articles, involving 702 eyes, met the inclusion criteria. The analysis revealed a significant reduction in the CVI among smokers (SMD: -0.61, 95% CI: -0.78 to -0.43, p < 0.00001), indicating compromised choroidal vascularity. In contrast, the impact of smoking on subfoveal choroidal thickness (SFCT) was not statistically significant (mean difference: 3.88 μm, 95% CI: -7.34 to 15.10, p = 0.50), with high heterogeneity (I² = 79%). Additionally, the full-retinal thickness (FRT) did not show a significant difference between smokers and nonsmokers.

Conclusion
Cigarette smoking negatively affects choroidal vascularity, as indicated by a significant reduction in CVI. However, its impact on FRT and SFCT remains unclear and requires further research. These findings highlight the importance of smoking cessation for eye health and suggest that CVI is a valuable noninvasive biomarker for monitoring vascular changes in smokers.

Trial registration
PROSPERO registration number: CRD42024627478.
The naked and the dead: an unusual case of sudden death
Authors: Sopková Dorota , Gurková Alica , Popaďák Peter 
Published: February 2025

Abstract

Background
In many societies, public nudity is a subject to a certain level of stigma associated with sexual deviance and perversion. Discovery of a naked body outdoors is considered a suspicious circumstance in forensic practice, most often leading to an assumption of sexually motivated homicide.

Case presentation
A 50-year-old man was found dead on a marked hiking trail; he was naked, wearing only a pair of socks and sneakers and a small backpack. No mechanical injuries were observed during the initial inspection at the scene. The reason for the man’s presence in the forest and his nudity was at that time unknown.

Conclusions
In the presented case, circumstantial evidence and autopsy findings led to a conclusion of a sudden cardiac death during naked hiking, a modern trend associated with naturism practice that is gradually gaining popularity around the world.
Vitamin D status, polymorphisms, and clinical outcomes in couples undergoing assisted reproductive technologies: exploring the role of 25(OH)D levels
Authors: Jreij Rana , Jounblat Rania , Mrad Youmna , Moussa Elie Hajj , Abdallah Maria , Fakih Chadi , Najjar Fadia , Hamade Aline 
Published: February 2025

Abstract

Purpose
Vitamin D status has been recognized as an important factor in human health, and its relevance in the context of couples utilizing assisted reproductive technologies is of particular interest.

Methods
This study aimed to assess the levels of 25(OH)D by ELISA in the biological fluids (serum, semen, and follicular fluid) of 105 couples undergoing in vitro fertilization or intracytoplasmic sperm injection. Additionally, the association among 3 vitamin D receptor polymorphisms (Apa1, Fok1, and Taq1) and vitamin D status, as well as the clinical pregnancy rate after in vitro fertilization, were investigated.

Results
The results revealed a high rate of hypovitaminosis in the women’s group. Furthermore, a significant difference was observed in the fertilization rate (P = 0.007). Correlations were found between Apa1 polymorphism and the number of collected oocytes (P = 0.014), the number of embryos (P = 0.001), the number of 2 pronuclear (P = 0.001), and the frequency of clinical pregnancies (P = 0.046). Additionally, correlations were found between Taq1 SNP and the number of embryos (P = 0.046) and the serum vitamin D level (P = 0.042). The Fok1 polymorphism showed correlations with semen concentration (P = 0.044) and clinical outcome (P = 0.032).

Conclusion
These results suggest the importance of systemic vitamin D for women prior to pregnancy. The findings emphasize the potential benefits of vitamin D supplementation in women before pregnancy and call for cautious interpretation of data regarding the impact of vitamin D on pregnancy.
Blocking Block Formation: Evidence from Private Loan Contracts
Authors: Akins Brian , De Angelis David , Zufarov Rustam 
Published: February 2025

Does the structure of the borrower’s equity ownership matter in debt contracting? This paper addresses this question by examining change in control clauses. These clauses are pervasive in loan contracts, yet their terms are not boilerplate. Examining 14,940 contracts, we document significant heterogeneity in the use and size of ownership caps, which limit large equity block formation. Overall, our evidence indicates that the way equity capital is distributed matters to lenders. Lenders set lower caps to mitigate risks arising from power contests among shareholders, formation of a new (coordinating) block, potentially resulting in activism, and hostile takeover threats via toehold strategies. We confirm some of these effects using two quasi-natural experiments. Caps below 50% are associated with a drop in firm value but not in the cost of debt, consistent with exacerbated firm-manager agency costs. Finally, two findings shed light on ways creditors may influence corporate governance: the largest block size increases when these minority block restrictions expire, and the likelihood of withdrawing an announced buyback increases during the life of these loans. This paper was accepted by Bo Becker, finance. Supplemental Material: The internet appendix and data files are available at https://doi.org/10.1287/mnsc.2023.04224 .
Institutional Ties and Publications in Top Accounting Journals
Authors: Whited Robert L. 
Published: February 2025

Academic journals certify and disseminate scientific knowledge. However, institutional ties between journals and universities can lead to conflicts of interest that compromise peer review. I consider publication patterns in the “Top 3” accounting journals in light of the journals’ governance structures and institutional ties. The Accounting Review (TAR), governed by the American Accounting Association (AAA), has no university affiliations. Journal of Accounting and Economics (JAE) and Journal of Accounting Research (JAR) are private journals with longstanding editorial ties to specific universities: the University of Rochester, the University of Pennsylvania, and Massachusetts Institute of Technology for JAE and the University of Chicago for JAR. For publications from 2000–2022, I find that journal-affiliated authors (current faculty and recent PhDs from journal-affiliated universities) publish disproportionately in their affiliate journal. Further analysis suggests that this pattern does not appear to be attributable primarily to authors’ journal submission preferences, particularly for JAR affiliates. In fact, JAR affiliates publish their least cited work in JAR (relative to TAR and JAE), and affiliate articles in JAR receive significantly fewer citations than articles in JAR by authors from top institutions unaffiliated with JAR. Results further suggest that institutional ties may be particularly impactful for pretenure PhD affiliates and for the publication of dissertations. The results are consistent with the idea that institutional ties may influence the publication process in accounting journals, particularly at JAR, where institutional affiliations are formalized and concentrated in one institution. This paper was accepted by Ranjani Krishnan, accounting. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2024.04553 .
Birt-Hogg-Dubé syndrome - a rare genetic disorder complicated by pneumothorax: A case report
Authors: Li Meng-Zhen , Deng Jun 
Published: February 2025

BACKGROUND
Birt-Hogg-Dubé (BHD) syndrome is a rare genetic disorder associated with mutations in the BHD gene, which can manifest symptoms at any age, including dermatological and pulmonary complications, as well as renal tumors. This study presents a case of a BHD patient who experienced spontaneous pneumothorax, aiming to enhance the understanding of this syndrome.
CASE SUMMARY
A 42-year-old female patient presented with left-sided chest pain and tightness lasting three days. Chest computed tomography scans revealed left-sided pneumothorax and multiple pulmonary bullae. Physical examination indicated decreased vocal fremitus and tympanic percussion on the left side. A thorough family history revealed a pattern of pulmonary disorders, including emphysema, spontaneous pneumothorax, and lung cancer among relatives. Genetic testing identified a heterozygous frameshift mutation in the FLCN gene at the 17p11.2 locus. Based on the clinical presentation, imaging findings, family history, and genetic results, the patient was suspected to have BHD syndrome.
CONCLUSION
We present a case of a heterozygous mutation in the FLCN gene in a patient with BHD syndrome, aiming to review the associated clinical characteristics and genetic mechanisms of this condition. This case serves as a reference point to offer insights into the diagnosis of multiple pulmonary cysts and spontaneous pneumothorax of unknown etiology in clinical practice.
The Role of Parent Advocacy in Autistic Youths’ Self-Determination
Authors: Moser Carly , Burke Meghan M. , DaWalt Leann Smith , Taylor Julie Lounds 
Published: February 2025

Abstract
Parent advocacy is important for the transition outcomes of autistic youth. However, it is unclear whether parent advocacy efforts support or stifle youths’ self-determination. This study examined concurrent (n = 180) and longitudinal (n = 134) associations between parent advocacy and transition-aged autistic youths’ self-determination (as reported by parents) and explored whether individual and family characteristics moderated this relationship. Cross-sectional results indicated a positive association between parent advocacy and self-determination for youth with higher adaptive behavior, lower externalizing behavior, and higher parent-child relationship quality. Longitudinal results demonstrated that change in parent advocacy related to change in self-determination for youth with lower adaptive behavior and higher externalizing behavior. Findings suggest that targeting parent advocacy could enhance self-determination skills in autistic youth.
Optimization Location Routing Problem (LRP) of Humanitarian Aid Distribution Using HGASA Method in Sigi District
Authors: Bombang Serli , Prasetya Ichiarto Bonivasius , Hardi Purba Humiras 
Published: February 2025

Disasters are events that disturb and threaten people's lives caused by nature or/and non-natural factors as well as human factors that cause casualties and economic losses. The polemic of uneven assistance and delays in the event of a natural disaster is the most common thing that occurs during a natural disaster. Location Routing Problem is a continuation of the classical routing problem that combines strategic and operational decisions with the facility location problem and the vehicle routing problem. This study aims to determine the location of the distribution centre construction and the optimal route using the Hybrid Genetic Algorithm and Simulated Annealing methods with the objective function of minimizing total costs and minimizing maximum service time for the distribution of humanitarian aid natural disaster 2018 in Sigi Regency. Optimization is designed into two scenarios, namely the construction of two distribution centres and three distribution centres. The result show that construction of two distribution centres can be designed at locations D3 and D5 with a total cost of IDR405 609 000 and a maximum travel time of 25.921 hours, while the construction of three distribution centres can be done at locations DC1, DC4 and DC 5 or with a total cost of IDR605,778,000 and a maximum service time of 19.634 hours.
Satellite-Based Validation of Contrail Prediction Models for Sustainable Aviation
Authors: Chandana Baddireddi Sree , Reddy Pelleti Nandieswar , Alapati Rithvika , Reddy Sai Aswath , Doraisamy Radha , Sankari Uma 
Published: February 2025

The aviation industry significantly contributes to global warming through the formation of contrails, which trap heat in the atmosphere and exacerbate climate change. To mitigate this effect, sophisticated models have been developed to predict contrail formation and its associated warming effects, but these require empirical validation for accuracy. This project leverages satellite imagery to validate contrail prediction models, enabling effective contrail avoidance strategies for airlines. U-Net variants, a convolutional neural network architecture, is utilized for image segmentation to identify contrails in satellite imagery. By optimizing the threshold for the softmax layer, contrail detection accuracy, and validating model predictions with real-world data had been enhanced. This enables pilots to minimize contrail formation during flights, aiming to reduce the aviation industry's environmental impact. The research offers a scalable and cost-effective solution for enhancing aviation sustainability and aligns with global efforts to combat climate change.
Assessing the clinical applicability of dimensionality reduction algorithms in flow cytometry for hematologic malignancies
Authors: Park Min-Seung , Lee Jong Kwon , Kim Boram , Ju Hee Young , Yoo Keon Hee , Jung Chul Won , Kim Hee-Jin , Kim Hyun-Young 
Published: February 2025

Abstract

Objectives
Despite its utility, interpreting multiparameter flow cytometry (MFC) data for hematologic malignancy remains time-intensive and complex. This study evaluated the applicability of two dimensionality reduction (DR) algorithms, t-distributed stochastic neighbor embedding (t-SNE) and uniform manifold approximation and projection (UMAP), to MFC data of hematologic malignancy.

Methods
A total of 237 samples were re-analyzed by t-SNE- and UMAP-based gating: 80 with acute leukemia orientation tube panel, 42 with B-cell lymphoma (BCL) panel, 45 with multiple myeloma (MM) panel, 40 and 30 with measurable residual disease (MRD) panels for B-cell acute lymphoblastic leukemia (B-MRD) and MM (MM-MRD), respectively. Each result was compared to the manual gating, and sensitivity and precision were assessed using BCL and B-MRD panels.

Results
Compared to manual gating, DR-based gating demonstrated agreements over 95.0 % for all MFC panels, and quantitative correlations (ρ) exceeded 0.94. Both t-SNE- and UMAP-based gating showed a sensitivity and negative predictive value of 100 %. Also, in one sample each from the BCL and MM-MRD panels, DR-based gating identified populations that were missed by manual gating. Sensitivity evaluation showed that both t-SNE- and UMAP-based gating successfully identified MRD populations down to the lowest MRD level of 10−5.30 when applying primary-gating strategy for CD19-positive population. Precision evaluation showed coefficient of variation below 10 % across all levels.

Conclusions
This study shows that DR-based gating streamlines data interpretation and minimizes overlooked populations, demonstrating significant potential as a valuable tool in MFC analysis for hematologic malignancies.
Two approaches of arithmetic units design
Authors: Gorodecky Danila 
Published: February 2025

Abstract
This paper proposes two approaches to design of arithmetic units. The first approach considers the result of calculations as the system of the positive polarity Reed-Muller expansions. The second approach decomposes arithmetic operations into a set of up to 5-input Boolean functions. Standard multipliers, multipliers by modulo, and composite operations in small-bit ranges are considered. An expression for the calculation of the most significant bit of modular multiplication is represented.
Saúde, família, segurança: para uma gramática moral do debate sobre cannabis medicinal
Authors: Alves Mourão Victor 
Published: February 2025

O presente texto explora analiticamente o debate sobre a regulamentação do uso medicinal da cannabis/maconha colocado pelo Projet de Lei 399/2015 da Câmara dos Deputados. O estudo, inspirado pela formulação teórica de Luc Boltanski, visa identificar eixos morais subjacentes ao debate, considerando os aspectos gerais e específicos das posições discursivas dos diferentes atores envolvidos na discussão sobre a cannabis medicinal no Brasil. A pesquisa identifica três citès principais no debate sobre a cannabis medicinal: saúde, família e segurança. Os achados apontam para considerações teóricas referentes à sobreposição de ordens morais na configuração de instituições sociais e na luta política de movimentos sociais progressistas.
Reimagining Blended Learning Post-COVID-19: Insights from EFL Students’ Narratives
Authors: Febrianto Aziza Restu , Talenta Pratama Irwin 
Published: February 2025

Background: During and after the COVID-19 pandemic, many academics and researchers in English Language Teaching (ELT) have studied a variety of issues faced in various types of online teaching and learning, including examining the efficacy of the Blended Learning (BL) approach as a result of the emergency remote and fully online learning or e-learning in response to the learning-from-home policy. Nevertheless, the researchers discovered that only a few studies employed a narrative inquiry method to explore students' perspectives, stories, and voices relating to their ways of learning during and after the pandemic.
Objective: This study helped the researchers better understand the challenges students faced and the adjustments they made, providing unique insights that other methods might miss.
Methods: This study addresses that gap by examining the stories and views of nine EFL students from three Indonesian universities who experienced various learning modes during and after the pandemic, including face-to-face, fully online, and blended classes. The students were requested to share their experiences and viewpoints about the BL approach through open-ended questionnaires and semi-structured interviews. The methods and tools from the narrative analysis were then employed to analyze the gathered stories and responses.
Findings: The findings indicate that while most students supported BL using appropriate online tools, their understanding of the approach varied, emphasizing the need for specific conditions for its successful implementation.
Conclusion: This study contributes to the understanding of the approach variations of BL.
DETERMINANTS OF TAX AVOIDANCE IN INDONESIA
Authors: Hartinah Siti , Ais Ghina Ridahatul 
Published: February 2025

ABSTRACTThe research aims to understand and test that tax avoidance can be influenced by audit committees, political connections, CSR and profitability. The research uses a quantitative research approach and data sources are obtained from annual financial reports. The population was obtained from mining sub-sector companies in Indonesia. Meanwhile, to determine the sample using a purposive sampling technique with samples that met the criteria of 15 companies and were studied over a 5 years period, namely 2017-2021 with a total of 75 samples. Meanwhile, to test the data and analyze it using multiple linear regression with the SPSS version 27 measuring tool. The results of this research state that Tax Avoidance cannot be significantly influenced by the Audit Committee. Meanwhile, Tax Avoidance can be influenced in a significantly positive direction by Political Connections. Profitability and Corporate Social Responsibility have a negative effect on Tax Avoidance.Keywords: Audit Committee; CSR; Political Connections; Profitability; and Tax Avoidance.
ABSTRAKPenelitian ini bertujuan untuk memahami dan menguji tax avoidance dapat dipengaruhi oleh komite audit, koneksi politik, CSR dan profitabilitas. Penelitian menggunakan metode dengan penelitian pendekatan kuantitatif dan sumber data diperoleh dari laporan keuangan tahunan. Populasi diperoleh dari perusahaan sub sektor pertambangan di Indonesia. Sementara itu, untuk menentukan sampel menggunakan teknik purposive sampling dengan sampel yang memenuhi kriteria sebanyak 15 perusahaan dan yang diteliti selama periode 5 tahun yaitu 2017-2021 dengan total 75 sampel. Sedangkan, untuk menguji data dan menganalisis menggunakan regresi linier berganda dengan alat pengukur program SPSS versi 27. Hasil dari penelitian ini menyatakan Tax Avoidance tidak dapat dipengaruhi secara signifikan oleh Komite Audit. Sementara itu, Tax dapat dipengaruhi dengan arah positif secara signifikan oleh Koneksi Politik. Untuk Profitabilitas dan Corporate Social Responsibility berpengaruh dengan arah negatif terhadap Tax Avoidance.Kata Kunci: CSR; Komite Audit; Koneksi Politik; Profitabilitas; dan Tax Avoidance.