bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring power reduction options for a single-chip multiprocessor through system-level modeling
Authors: La Fratta Patrick Anthony , Baker James M. 
Published: January 2025

Moore's law predicts that fabrication processes will soon yield over a billion transistors on a single die. Over the past twenty years, the gap between the amount of available real estate on a chip and designer productivity has widened and continues to grow, so that designers are less able to make effective use of the increasing number of transistors on a chip. The primary problem in system-on-a-chip (SoC) design is no longer the limit on the number of resources. Rather, the development of new methodologies and system-level design tools is the challenge that lies ahead, as these have become essential to keeping costs low in the planning and construction of these systems. Designers have realized that the consideration of the overwhelming details at register-transfer level (RTL) early in development restricts design space exploration, inhibits trade-off evaluation, and results in increased time-to-market. In order to effectively utilize the available resources, the entry point of design flows in recent methodologies is at higher levels of abstraction, with consideration to significantly fewer details of the final hardware implementation. In recent years, we have also seen the introduction of single-chip multiprocessors. As new tools and methodologies emerge for abstract system design, proposed solutions to the arising problems in the performance of single-chip multiprocessors can be implemented and evaluated more efficiently. For example, the amount of on-chip memory for such parallel systems continues to steadily rise, but so does the amount of power used by the memory system. In this work, we apply novel design methodology and tools to a single-chip multicore architecture, considering alternatives for power reduction of the storage components through system-level modeling.
Instruction Reuse in SPEC, media and packet processing benchmarks: A comparative study of power, performance and related microarchitectural optimizations
Authors: Surendra G. , Banerjee Subhasis , Nandy S.K. 
Published: January 2025

The effectiveness of Instruction Reuse (IR) – a technique to eliminate redundant computations at run time – is limited by the fact that performance gain seldom exceeds 3% and is dependent on the criticality of instructions being “reused”. In this paper, we focus on the power aspect of IR and propose a “resultbus optimization” that exploits communication reuse to reduce the power dissipated over a high capacitance resultbus. The effectiveness of this optimization depends on the number of result producing instructions that are reused and improves overall power and Energy-Delay Product (EDP) by 3% over a base IR policy for a 1024 entry “Reuse Buffer” (RB). As a domain specific study, we examine the impact of multithreading on IR in the context of packet header processing applications. Specifically, sharing the RB among threads can lead to either constructive or destructive interference, thereby increasing or decreasing the amount of IR that can be uncovered. Further, packet header processing applications are unique in the sense that repetition in data values within “flows” are quite prevalent which can be exploited to improve IR. We find that an architecture that uses this “flow” information to govern accesses to the RB improves IR by as much as 4.6% for header processing kernels.
Guia Beabá do Câncer: Validação de Livro Educativo para Crianças, Famílias e Profissionais de Saúde
Authors: Mozzilli Simone Lehwess , Prates Pedro Emílio Gomes , Pecenin Isadora Cardoso Salles Fila , Silva Lucas Thiago Pereira da , Salvetti Marina de Góes 
Published: January 2025

Introdução: O diagnóstico de câncer infantil gera medo, angústia e sofrimento para pacientes e suas famílias, impactando negativamente a comunicação e a adesão ao tratamento. Materiais educativos validados podem melhorar a compreensão e a participação ativa no cuidado. Objetivo: Validar o conteúdo do livro educativo “Guia Beabá do Câncer” sob a perspectiva de crianças, adolescentes, famílias e profissionais da saúde. Método: Estudo metodológico de validação de conteúdo utilizando o método Suitability Assessment of Materials (SAM) para avaliar a adequação do material em seis categorias (conteúdo, linguagem, ilustração, apresentação, motivação e adaptação cultural) e indicadores da experiência do usuário. Os dados foram coletados virtualmente, via Adobe Sign, e analisados no software Statistical Package for the Social Sciences (SPSS), utilizando-se indicadores como clareza, vocabulário, atratividade e usabilidade. Resultados: Participaram do estudo 12 crianças e adolescentes, 20 familiares e 29 profissionais da saúde. O material foi validado com escores de 100% pelas crianças e adolescentes, 98,4% pelos familiares e 97,6% pelos profissionais de saúde, superando os escores mínimos de 40% e 60%, necessários para considerar o material adequado ou superior ao adequado. Foram feitas sugestões de melhorias nas áreas de clareza e vocabulário, especialmente para públicos com menor letramento em saúde. Conclusão: O “Guia Beabá do Câncer” foi validado como uma ferramenta adequada para a educação em saúde de crianças em tratamento oncológico e seus familiares. Estudos futuros são recomendados para avaliar o impacto do guia na prática clínica e na melhoria da adesão ao tratamento.
Edukasi Pemanfaatan Tanaman Di Bantaran Sungai Sebagai Alternatif Obat Bagi Warga Kampung Hijau, Kelurahan Sungai Bilu, Kalimantan Selatan
Authors: Komaliya Risyda , Audina Mia , Firdaus Muhammad Rifqi , Ipnas Rini Ardila , Aisyiyah Siti , Meliyani Tri 
Published: January 2025

Tanaman bantaran sungai memiliki potensi besar sebagai alternatif obat, namun kurangnya pengetahuan dan keterampilan warga Kampung Hijau, Kelurahan Sungai Bilu, Kalimantan Selatan dalam memanfaatkannya menjadi salah satu permasalahan utama di daerah ini. Untuk mengatasi permasalahan tersebut, dilakukan kegiatan pengabdian warga dengan tujuan meningkatkan pengetahuan warga dalam pemanfaatan tanaman obat. Metode yang digunakan dalam kegiatan ini adalah diskusi kelompok yang melibatkan 19 warga Sungai Bilu dengan media leaflet sebagai sarana edukasi. Selain itu, pretest dan posttest digunakan untuk mengukur efektivitas kegiatan dalam meningkatkan pengetahuan warga. Data yang diperoleh dari pretest dan posttest dianalisis untuk melihat peningkatan pemahaman peserta mengenai manfaat dan cara penggunaan tanaman obat. Hasil perbandingan sebelum dan sesudah kegiatan memberikan gambaran yang jelas mengenai efektivitas materi dan metode yang digunakan. Kegiatan Pengabdian Kepada Masyarakat ini berhasil meningkatkan pengetahuan dan keterampilan warga Kampung Hijau dalam memanfaatkan tanaman di bantaran sungai sebagai alternatif obat.
Pemanfaatan Tanaman Obat Sebagai Bahan Ajar Muatan Lokal Di SDI Mohammad Hatta Malang
Authors: Zubair Anis , Satriyawan Haris , Hairunisya Nanis , Yuliati Ninik Catur Endah , Sonalitha Elta , Agung Adha Muhammad Nibras , Fridayanti Dinda Ahsana Zahra 
Published: January 2025

Masalah lingkungan menjadi isu global yang mendesak. Pendidikan lingkungan sejak dini menjadi salah satu solusi untuk mengatasi permasalahan tersebut. Penelitian ini bertujuan untuk meningkatkan kesadaran lingkungan siswa melalui pemanfaatan tanaman obat sebagai bahan ajar muatan lokal di SDI Mohammad Hatta Malang. Metode yang digunakan adalah pendekatan partisipatif dengan melibatkan siswa dalam kegiatan pengenalan, penanaman, dan pengolahan tanaman obat. Populasi dalam penelitian ini adalah seluruh siswa SDI Mohammad Hatta Malang, sedangkan sampelnya adalah siswa kelas 5 dan 6. Teknik pengumpulan data dilakukan melalui observasi, wawancara, dan dokumentasi. Hasil kegiatan menunjukkan bahwa kegiatan ini berhasil meningkatkan pengetahuan siswa tentang keanekaragaman hayati, pentingnya menjaga lingkungan, dan manfaat tanaman obat. Selain itu, siswa juga menunjukkan peningkatan keterampilan berpikir kritis, kreativitas, dan kemampuan bekerja sama. Sebagai rekomendasi, perlu adanya pengembangan kurikulum yang lebih terintegrasi dengan muatan lokal dan peningkatan ketersediaan sarana dan prasarana pendukung.
Penerapan Ipteks Untuk Meningkatkan Mutu Olahan Kunyit Di Desa Kesamben Wetan, Kabupaten Gresik
Authors: Saidah Saidah , Siswati Endang , Srianta Srianta , Afianti Hasti 
Published: January 2025

Desa Kesamben Wetan merupakan salah satu desa di Kecamatan Driyorejo, Kabupaten Gresik yang mempunyai produk unggulan berupa kunyit. Kelompok Tani (Mitra 2) terdiri dari 26 petani, menjual kunyit hasil panen tersebut ke UKM (Mitra 1). Mitra 1 menjual kunyit dalam bentuk kunyit basah dan kunyit olahan kering. Permasalahan pada olahan kunyit kering yang dijual tidak melalui proses pencucian sehingga banyak pasir yang menempel dan kunyit sebelum dikeringkan tidak melalui proses blanching sehingga banyak mengandung mikroorganisme dan kadar air yang tinggi. Untuk mengatasi permasalahan tersebut, tim pengabdian memberikan penerapan IPTEKS pada Mitra 2 berupa mesin pencuci kunyit agar kunyit yang dijual ke mitra 1 sudah dalam keadaan bersih, higienis dan pada Mitra 1 berupa mesin pengukus kunyit untuk proses blanching agar kunyit sebelum dikeringkan terbebas dari mikroorganisme, mempercepat proses pengeringan dan memiliki kwalitas baik. Metode yang digunakan yaitu persiapan, pemberian TTG mesin pencuci, pengukus, pelatihan penggunaan dan maintenance mesin, pendampingan sampai diperoleh hasil yang diinginkan. Mesin tersebut sudah melalui proses rancang bangun dengan menyesuaikan kebutuhan Mitra. Mesin pencuci kunyit berkapasitas 50-80 kg/jam menghasilkan kunyit yang bersih dan higienis, demikian juga untuk mesin pengukus kunyit berkapasitas 30 kg/10 menit menghasilkan kunyit dengan curcumin yang merata diseluruh permukaan kunyit.
Penataan Taman Di TK Islam Terpadu Al-Ma’Un, Kecamatan Dau, Kabupaten Malang
Authors: Asnah Asnah , Budiyono Debora , Sumiati Astri 
Published: January 2025

Keberadaan sebuah ruang terbuka hijau pada sebuah area pendidikan untuk meningkatkan minat belajar dan bermain anak-anak sekolah. Sekolah TK Islam Terpadu Al-Ma’Un merupakan salah satu sekolah yang membutuhkan area bermain yang fungsional dan estetik. Kondisi sekolah yang berada di sekitar permukiman sehingga tidak memiliki luas taman yang memadai oleh karena itu memanfaatkan lahan yang tersedia untuk sebuah taman bermain bagi anak-anak. Tim pengabdian kepada masyarakat Universitas Tribhuwana Tunggadewi membantu permasalahan yang dihadapi mitra agar memiliki sebuah taman bermain. Tujuan kegiatan pengabdian kepada masyarakat ini adalah menata taman di TK Islam Terpadu Al-Ma’Un, Kecamatan Dau, Kabupaten Malang yang dapat meningkatkan minat belajar dan bermain anak-anak. Tim pengabdi menggunakan teknik observasi dan wawancara dalam proses pembuatan taman. Tahapan kegiatan ini adalah persiapan, pelaksanaan, dan evaluasi. Hasil kegiatan pengabdian kepada masyarakat adalah sebuah karya taman sekolah yang fungsional dan estetika yang meningkatkan minat belajar dan bermain anak-anak sekolah Tk Islam Terpadu Al-Ma’Un.
Sistem Speed Sensorless Vertical Axis Wind Turbine dengan Fuzzy Time Series Model Chen
Authors: Melfazen Oktriza , Dewatama Denda , M. Taqijuddin Alawiy  
Published: January 2025

Pemanfaatan energi angin sebagai Pembangkit Listrik Tenaga Bayu di wilayah Indonesia perlu pengolahan dengan cermat, karena kecepatan angin rata-rata harian yang berkisar antara 2,5 – 6 m/s merupakan kategori kecepatan angin kelas rendah hingga menengah. Penelitian tentang prediksi kecepatan angin pada Vertical-Axis Wind Turbine (VAWT) menggunakan klasifikasi fuzzy time series ini dimaksudkan untuk menggantikan sensor kecepatan dalam mendeteksi dan mendapatkan potensi kecepatan angin terbaik untuk menghasilkan tegangan listrik maksimal sepanjang catur wulan pertama dalam satu tahun. Algoritma fuzzy time series Chen mampu melakukan prediksi kecepatan angin untuk menghasilkan tegangan listrik pada sistem VAWT 800 Watt sehingga sistem dapat beroperasi dengan mode tanpa sensor namun tetap dapat mengukur kecepatan angin dengan akurasi hingga 70%.
The Implementation of a Sustainable Food and Agricultural Land Protection Policy in Pringsewu District
Authors: Sormin Rahma Diani 
Published: January 2025

The development in Pringsewu District is currently being monitored at a rapid pace, with the function of rice field land being reactivated as a growing land. The increasing population and growing needs of the community present a significant threat to the continued existence of productive rice fields. Pringsewu District is an urban area where the majority of existing land has the potential to be transformed into agricultural land. This phenomenon presents an intriguing case study for examining the implementation of regional regulations in Pringsewu Regency, specifically Regulation Number 6 of 2015 regarding the sustainable protection of food farming land. The research method employs a descriptive qualitative approach, utilizing data collection techniques such as interviews, observations, and documentation. The implementation of Regional Regulation No. 6 of 2015 regarding the protection of sustainable food farming land has not been effectively carried out. This is due to a lack of public awareness concerning the significance of sustainable food agricultural land. Despite the challenges inherent in implementing Local Regulation No. 6 of 2015 on sustainable food farm protection, the Pringsewu district government has consistently endeavored to ensure that the development of Pringsewu regency is guided by Local Regulation No. 6 of 2015 on sustainable food agricultural land protection. This approach is designed to facilitate a harmonious relationship between development and the environment.
Keywords: food farming, implementation, regulation, sustainable.
Implementasi Program Electronic Traffic Law Enforcement (ETLE) di Kota Serang
Authors: Jannah Lailatul , Pratiwi Cintabi Dwi , Arwati  , Nazwa Sabita 
Published: January 2025

Research objective: to make people obedient and obedient in traffic. Seeing that traffic styles on the road are becoming more complex daily, as well as rampant violations, drivers who obey only when there are traffic officers have influenced the presence of the Electronic Traffic Law Enforcement (ETLE) policy. Serang City, as the central government in Banten Province, became the first city/district to implement ETLE, specifically in Jalan Veteran Serang City, in April 2021. As the years go by, ETLE in the jurisdiction of the Banten Regional Police continues to increase. The addition of ETLE location points in Serang City is becoming increasingly massive, so implementing the ETLE policy faces many challenges. This research was designed using qualitative methods based on the Policy Implementation theory by Merilee S. Grindle. The ETLE policy is a step taken by the government to create traffic discipline and order to minimize violations that occur on the highway. The research results stated that the implementation of the ETLE policy in Serang City was considered successful as measured by the quality of the implementation process, which was in accordance with what was stipulated and the achievement of policy objectives by what was targeted. This research also shows that the implementation of ETLE has had a significant positive impact on society. The community has a habitual pattern of obeying traffic and transparent law enforcement.
MLL4 regulates postnatal palate growth and midpalatal suture development
Authors: Lee Jung-Mi , Jung Hunmin , Pasqua Bruno de Paula Machado , Park Yungki , Tang Qinghuang , Jeon Shin , Lee Soo-Kyung , Lee Jae W. , Kwon Hyuk-Jae Edward 
Published: January 2025

MLL4, also known as KMT2D, is a histone methyltransferase that acts as an important epigenetic regulator in various organogenesis programs. Mutations in the MLL4 gene are the major cause of Kabuki syndrome, a human developmental disorder that involves craniofacial birth defects, including anomalies in the palate. This study aimed to investigate the role of MLL4 and the underlying mechanisms in the development and growth of the palate. We generated a novel conditional knockout (cKO) mouse model with tissue-specific deletion of Mll4 in the palatal mesenchyme. Using micro-computed tomography (CT), histological analysis, cell mechanism assays, and gene expression profiling, we examined palate development and growth in the Mll4-cKO mice. Gross craniofacial examination at adult stages revealed mild midfacial hypoplasia and midline defects of the palate in Mll4-cKO mice, including a widened midpalatal suture and disrupted midline rugae pattern. Micro-CT-based time-course skeletal analysis during postnatal palatogenesis through adulthood demonstrated a transverse growth deficit in overall palate width in Mll4-cKO mice. Whole-mount and histological staining at perinatal stages identified that the midline defects in the Mll4-cKO mice emerged as early as 1 day prior to birth, presenting as a widened midpalatal suture, accompanied by increased cell apoptosis in the suture mesenchyme. Genome-wide mRNA expression analysis of the midpalatal suture tissue revealed that MLL4 is essential for the timely expression of major cartilage development genes, such as Col2a1 and Acan, at birth. Immunofluorescence staining for osteochondral differentiation markers demonstrated a marked decrease in the chondrogenic marker COL2A1, while the expression of the osteogenic marker RUNX2 remained unchanged, in the Mll4-cKO midpalatal suture. Additionally, SOX9, a master regulator of chondrogenesis, exhibited a significant decrease in protein expression. Indeed, time-course histological analysis during postnatal palate growth revealed retardation in the development of the suture cartilage in Mll4-cKO mice. Taken together, our results demonstrate that MLL4 is essential for orchestrating key cellular and molecular events that ensure proper midpalatal suture development and palate growth.
Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis
Authors: Hu Zhihong , Hou Xixi , Ren Yongjing , Wu Ziyuan , Yan Dong , Chen Hong , Wang Lan 
Published: January 2025

Cervical cancer ranks as the fourth most common cancer among women. However, the current treatments have significant side effects and limited therapeutic effects on advanced diseases, so it is necessary to discover better treatments for cervical cancer. The current study investigated the potential anticancer effects of a series of gefitinib-1,2,3-triazole derivative on Hela cells. Among the investigated, the target compound c13 showed good anticancer activity against Hela cells (IC50 = 5.66 ± 0.35 μM) compared with gefitinib (IC50 = 14.18 ± 3.19 μM). Moreover, compound c13 significantly inhibited the colony formation ability of Hela cells in a dose-dependent manner, accompanied by morphological changes in HeLa cells. Further investigations demonstrated that compound c13 triggered cell apoptosis and arrested the cell cycle at the G2/M phase in Hela cells. In addition, western blot analysis revealed that compound c13 upregulated the Bax/Bcl-2 ratio, and increased the levels of active caspase 3 and PARP1 cleavage, which suggested the involvement of the mitochondrial pathway in compound c13-induced apoptosis. In brief, these results indicated that compound c13 is a promising compound for the treatment of cervical cancer.
Hexagonal zinc oxide nanoparticles: a novel approach to combat multidrug-resistant Enterococcus faecalis biofilms in feline urinary tract infections
Authors: Sewid Alaa H. , Sharaf Mohamed , El-Demerdash Azza S. , Ragab Sherif M. , Al-Otibi Fatimah O. , Taha Yassin Mohamed , Liu Chen-Guang 
Published: January 2025

IntroductionEnterococcus faecalis, a common inhabitant of the feline gastrointestinal tract, has emerged as a significant pathogen causing urinary tract infections (UTIs) in domestic cats. The rise of multidrug-resistant E. faecalis strains and their propensity to form biofilms pose significant challenges in treatment. This study investigated the antibacterial and antibiofilm activities of hexagonal zinc oxide nanoparticles (ZnONPs) alone and in combination with streptomycin and Moringa oleifera leaf extract (MOLe) against multidrug-resistant E. faecalis isolates from feline UTIs.MethodsAntimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method. Biofilm formation was assessed using the crystal violet assay, and biofilm-associated genes (sprE, gelE, fsrABC) were detected by PCR. ZnONPs, Str/ZnONPs (streptomycin-loaded ZnONPs), and Str/MOLe@ZnONPs (streptomycin and MOLe-loaded ZnONPs) were characterized using FTIR, DLS, TEM, and SEM. The antibacterial and antibiofilm activities of the synthesized nanoparticles were evaluated through time-kill assays, well diffusion assays, and gene expression analysis.ResultsA high prevalence of multidrug resistance was observed among the E. faecalis isolates, with significant resistance to ampicillin, vancomycin, and streptomycin. Characterization studies revealed the successful encapsulation of streptomycin and MOLe within the ZnONPs.In vitro assays demonstrated that Str/MOLe@ZnONPs exhibited potent antibacterial and antibiofilm activities against the tested E. faecalis strains, significantly reducing bacterial growth and biofilm formation.DiscussionThe emergence of multidrug-resistant E. faecalis strains necessitates the development of novel therapeutic strategies. This study demonstrates the promising potential of ZnONPs, particularly those loaded with streptomycin and MOLe, in combating biofilm-forming E. faecalis. The synergistic effects of the combined formulation may offer a novel approach to overcome antibiotic resistance and improve the treatment outcomes of E. faecalis UTIs in domestic cats.