bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of different definitions on the interpretation of coronary remodeling determined by intravascular ultrasound
Authors: Hibi Kiyoshi , Ward Michael R. , Honda Yasuhiro , Suzuki Takeshi , Jeremias Allen , Okura Hiroyuki , Hassan Ali H.M. , Maehara Akiko , Yeung Alan C. , Pasterkamp Gerard , Fitzgerald Peter J. , Yock Paul G. 
Published: April 2005

AbstractThe objective of this study was to compare the categorizations and determinants related to remodeling by the three definitions commonly used. Several morphological and intravascular ultrasound (IVUS) studies have demonstrated the fundamental importance of arterial remodeling in atherosclerosis. However, lack of consensus on how to define remodeling has led to conflicting analyses of factors that influence this process. Analysis of preinterventional IVUS images of 514 lesions in native coronary arteries was performed. Arterial remodeling was defined as outward by definition 1, when [cross‐sectional area (CSA) of the external elastic membrane (EEM) at the lesion site (EEMlesion)]/[EEM CSA either at the proximal (EEMprox ref) or distal (EEMdistal ref) reference site with the least amount of plaque] was > 1.05, intermediate when this ratio was between 0.95 and 1.05, and inward when < 0.95. Remodeling was defined as outward by definition 2 when EEMlesion > both EEMprox ref and EEMdistal ref, inward when EEMlesion < both EEMprox ref and EEMdistal ref, and intermediate when EEMlesion was intermediate between EEMprox ref and EEMdistal ref. By definition 3, vessel remodeling was defined as outward when EEMlesion > (EEMprox ref + EEMdistal ref)/2 and intermediate/inward when EEMlesion ≤ (EEMprox ref + EEMdistal ref)/2. The frequency of outward remodeling was significantly higher by definitions 1 and 3 than by definition 2, whereas a higher frequency of inward remodeling was observed in definition 1, resulting in significantly different remodeling distributions between the three definitions (P < 0.0001). By multivariate logistic analysis, the only clinical determinants related to outward remodeling was younger age, and only by definition 3. IVUS determinants varied significantly between the three definitions. The only consistent determinants among the three definitions were smaller lumen CSA at the reference site and larger plaque + media CSA at the lesion site. This study demonstrates the significant impact of different remodeling definitions on the incidence and determinants of remodeling patterns. The marked variability in categorization of remodeling underscores the importance of developing a standard methodology. © 2005 Wiley‐Liss, Inc
The Bivalent Metal Hypophosphites Sr(H2PO2)2, Pb(H2PO2)2 and Ba(H2PO2)2.
Authors: Kuratieva Natalia V. , Naumova Marina I. , Podberezskaya Nina V. , Naumov Dmitry Yu. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two New Phosphate Langbeinites, Rb2YbTi(PO4)3 and Rb2Yb0.32Ti1.68 (PO4)3, Investigated at 293 and 150 K.
Authors: Gustafsson Joacim C. M. , Norberg Stefan T. , Svensson Goeran , Albertsson Joergen 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sr11Ge4N6: A New Nitride Composed of [GeN2Sr7]4+ Antiperovskite‐Type Slabs and [Sr4Ge]4+ Layers, Separated by Sheets of Bent [GeIIN2]4‐ Ions.
Authors: Gal Zoltan A. , Clarke Simon J. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Tandem Michael Addition—Carbene Insertion Reaction of 1‐Alkynyl(aryl)(tetrafluoroborato)‐λ3‐bromanes: 1‐(Phenylsulfonyl)‐ and 1‐(Trifluoromethylsulfonyl)cyclopentene Annulation.
Authors: Ochiai Masahito , Tada Norihiro , Nishi Yoshio , Murai Kentaro 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Productive Chloroarene C—Cl Bond Activation: Palladium/Phosphine‐Catalyzed Methods for Oxidation of Alcohols and Hydrodechlorination of Chloroarenes.
Authors: Bei Xiaohong , Hagemeyer Alfred , Volpe Anthony , Saxton Robert , Turner Howard , Guram Anil S. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Effective Peroxidic Epoxidation of Olefins Using Hexathiocyanatorhenate(IV) as Catalyst and Bicarbonate as Co‐Catalyst.
Authors: Dinda Subhajit , Chowdhury Sujoy Roy , Malik K. M. Abdul , Bhattacharyya Ramgopal 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Entirely New Methodology for Synthesizing Perfluorinated Compounds. Synthesis of Perfluoroalkanesulfonyl Fluorides from Non‐Fluorinated Compounds.
Authors: Okazoe Takashi , Murotani Eisuke , Watanabe Kunio , Itoh Masahiro , Shirakawa Daisuke , Kawahara Kengo , Kaneko Isamu , Tatematsu Shin 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reactions of 2,3,5‐Trichloro‐4,4‐ethylenedioxy‐2‐cyclopentenone with Some Ambident Nucleophiles. Sterically Loaded Functionalized 6‐Azabicyclo[3.1.0]hex‐5‐enes.
Authors: Shavaleeva G. A. , Ivanova N. A. , Usmanova F. G. , Akhmetvaleev R. R. , Miftakhov M. S. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ruthenium‐ and Gold‐Catalyzed Sequential Reactions: A Straightforward Synthesis of Substituted Oxazoles from Propargylic Alcohols and Amides.
Authors: Milton Marilyn Daisy , Inada Youichi , Nishibayashi Yoshiaki , Uemura Sakae 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Approach to the Synthesis of 2‐Aryl‐4‐halomethyl‐5‐methyl‐1,3‐oxazoles by Highly Regioselective Direct Halogenation with NBS or NCS/MeCN.
Authors: Yamane Taihei , Mitsudera Hiroyuki , Shundoh Takatsugu 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Silica Gel Supported InBr3 and InCl3: New Catalysts for the Facile and Rapid Oxidation of 2′‐Hydroxychalcones and Flavanones to Their Corresponding Flavones under Solvent Free Conditions.
Authors: Ahmed Naseem , Ali Hasrat , van Lier Johan E. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Facile Synthesis of 2,3‐Disubstituted‐6‐arylpyridines from Enaminones Using Montmorillonite K10 as Solid Acid Support.
Authors: Reddy G. Jagath , Latha D. , Thirupathaiah C. , Rao K. Srinivasa 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 6‐Bromomethyl‐Substituted Derivatives of Pyridin‐2(1H)‐ones and Their Reaction with Nucleophiles.
Authors: Kalme Z. A. , Zhalubovskis R. A. , Shmidlers A. , Celmins J. , Duburs G. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Kishner Reduction of 3,3‐Dimethyl‐6‐trifluoromethyl‐1,2,3,4‐tetrahydroindolo [2,3‐c]quinolin‐1‐one.
Authors: Kibal'ny A. V. , Afonin A. A. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 2‐Aryl and 2‐Hetaryl Derivatives of 2′‐Aminospiro[(1,3‐dioxane)‐5,5′‐thiazolin]‐4′‐one and Spiro[(1,3‐dioxane)‐5,5′‐thiazolidine]‐2′,4′‐dione
Authors: Ramsh S. M. , Ivanenko A. G. , Shpilyovy V. A. , Medvedskiy N. L. , Kushakova P. M. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselectivity of Nucleophilic Attack in the Reactions of 1,2,4‐Triazine 4‐Oxides with Certain C‐Nucleophiles.
Authors: Kozhevnikov D. N. , Prokhorov A. M. , Rusinov V. L. , Chupakhin O. N. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Benz[5,6]azepino[4,3‐b]indoles by 1,7‐Electrocyclization of Azomethine Ylides.
Authors: Nyerges Miklos , Pinter Aron , Viranyi Andrea , Bitter Istvan , Toeke Laszlo 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
10‐Aryl‐7,7‐dimethyl‐5,6,7,8,9,10‐hexahydro‐11H‐pyrido[3,2‐b] [1,4]benzodiazepin‐9‐ones.
Authors: Tonkikh N. N. , Strakovs A. , Petrova M. V. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
11‐Aryl‐3,3‐dimethyl‐7‐ and 7,8‐Substituted 1,2,3,4,10,11‐Hexahydro‐5H‐dibenzo[b,e]‐1,4‐diazepin‐1‐ones.
Authors: Tonkikh N. N. , Strakovs A. , Rizhanova K. V. , Petrova M. V. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Urease Inhibiting Guaianolides from Amberboa ramosa.
Authors: Khan S. B. , Riaz N. , Afza N. , Malik A. , Azhar‐ul‐Haq Azhar‐ul‐Haq , Ahmed Z. , Lodhi M. A. , Choudhary M. I. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Germacranolides from Calea urticifolia.
Authors: Yamada Masashi , Matsuura Nobuyasu , Suzuki Hiroto , Kurosaka Chihiro , Hasegawa Naoko , Ubukata Makoto , Tanaka Toshiyuki , Iinuma Munekazu 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Alkaloids of Arundo donax L. Part 15. A New Dimeric Indole Alkaloid Arundarine from the Roots of Arundo donax L
Authors: Khuzhaev V. U. , Zhalolov I. Zh. , Levkovich M. G. , Aripova S. F. , Shashkov A. S. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Solvent‐Free Synthesis of 2′,3′,5′‐Tri‐O‐acetyl‐2,6‐dichloropurine Nucleoside Catalyzed by p‐Toluenesulfonic Acid Using Microwave.
Authors: Qu Guirong , Liu Qibin 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthetic Methods, Anticoagulation Activity and Toxicity of 2‐Acyl Substituted Derivatives of Indane‐1,3‐dione
Authors: Karakotov S. D. , Shapilova V. V. , Chimishkyan A. L. , Kozenasheva L. Ya. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Postoperative complications of salvage total laryngectomy
Authors: Ganly Ian , Patel Snehal , Matsuo Jeanette , Singh Bhuvanesh , Kraus Dennis , Boyle Jay , Wong Richard , Lee Nancy , Pfister David G. , Shaha Ashok , Shah Jatin 
Published: April 2005

AbstractBACKGROUNDThe objectives of the current study were to report the incidence of postoperative complications for salvage total laryngectomy (STL) compared with primary total laryngectomy (PTL) and to identify patient and tumor‐related factors predictive of postoperative complications.METHODSA sample of 183 patients who had received a total laryngectomy were identified from an existing database of 662 patients treated for squamous cell carcinoma of the larynx. PTL and STL were performed in 113 and 70 patients, respectively. Initial therapy in the patients who required salvage surgery included radiotherapy (RT) in 32 (46%) and chemoradiotherapy (CTRT) in 38 (54%). Postoperative complications were recorded for each group and categorized into local, swallowing, airway, and systemic complications. Postoperative complication rates for STL after RT and CTRT were compared with those after PTL by univariate analysis. Patient and tumor‐related predictors of complications were identified by univariate and multivariate analyses.RESULTSThe overall mortality rate was 0.5%. Forty percent of all patients developed a postoperative complication after total laryngectomy. Local complications, which were the most frequent, occurred in 52 (28%) patients. Pharyngocutaneous fistula occurred in 31 (17%) patients. Statistical analysis showed that there was a greater number of patients with local wound (45% vs. 25%, P = 0.02) and fistula complications (32% vs. 12%, P = 0.012) in the STL‐CTRT group compared with the primary laryngectomy group. Multivariate analysis showed that primary CTRT was an independent predictor of local complications and pharyngocutaneous fistula.CONCLUSIONSSalvage laryngectomy was more frequently associated with postoperative complications after CTRT compared with PTL. Problems related to local wound healing, especially the development of pharyngocutaneous fistula, constituted the most common postoperative complication in these patients. Multivariate analysis showed that primary CTRT was an independent predictor of local wound complications and pharyngocutaneous fistula. Cancer 2005. © 2005 American Cancer Society.
Prognostic factors and treatment of patients with T‐cell non‐Hodgkin lymphoma
Authors: Escalón Maricer P. , Liu Nina S. , Yang Ying , Hess Mark , Walker Pamela L. , Smith Terry L. , Dang Nam H. 
Published: April 2005

AbstractBACKGROUNDT‐cell non‐Hodgkin lymphomas (T‐NHL) are more aggressive and patients have a poorer prognosis compared with patients with the corresponding B‐cell lymphomas. Although intensive treatments have been developed, it is unknown whether they are more effective than CHOP chemotherapy (cyclophosphamide, doxorubicin, oncovorin, and prednisone).METHODSThe authors' retrospective study evaluated the clinical outcome of 135 previously untreated patients with T‐NHL who were treated at The University of Texas M. D. Anderson Cancer Center (Houston, TX) between 1996 and 2002. Lymphomas with T‐cell histologies with the exception of mycosis fungoides were included.RESULTSThe estimated median overall survival was 46 months. Thirty‐seven percent of the patients received CHOP therapy, 48% received intensive therapy, and 15% received other therapy. The estimated 3‐year overall survival rates were 62% for the patients treated with CHOP therapy and 56% for the patients who received intensive therapy. After the exclusion of patients with anaplastic large cell lymphoma (ALCL), who are known to have a better prognosis than patients with other T‐NHLs, the estimated 3‐year overall survival rates were 43% for the patients treated with CHOP therapy and 49% for the patients who received intensive therapy. Parameters that may be independent prognostic factors for survival in T‐NHL, excluding ALCL, included ECOG performance status ≥ 2, beta‐2‐microglobulin level > 2 mg/L, lactate dehydrogenase level higher than normal, bulky disease ≥ 7 cm, and a higher international prognostic index and tumor score.CONCLUSIONSThe current study data suggested that patients treated with intensive therapies did not fare better than those treated with CHOP therapy. New treatment regimens need to be developed for patients with T‐NHL. Cancer 2005. © 2005 American Cancer Society.
Imatinib mesylate lacks activity in small cell lung carcinoma expressing c‐kit protein
Authors: Krug Lee M. , Crapanzano John P. , Azzoli Christopher G. , Miller Vincent A. , Rizvi Naiyer , Gomez Jorge , Kris Mark G. , Pizzo Barbara , Tyson Leslie , Dunne Megan , Heelan Robert T. 
Published: April 2005

AbstractBACKGROUNDImatinib inhibits the c‐kit tyrosine kinase, which, accounts for its activity in gastrointestinal stromal tumors. The presence of c‐kit protein expression in small cell lung carcinoma (SCLC) tumor specimens, as well as in vitro data supporting the role of c‐kit in autocrine and paracrine growth stimulation specifically in SCLC, provided a rationale for studying imatinib in this disease. The authors conducted a Phase II single‐institution study of imatinib in patients with recurrent SCLC whose tumor specimens expressed c‐kit protein.METHODSPatients with progressive SCLC after one or two previous chemotherapy regimens consented to have their tumor specimens screened by immunoperoxidase stain (CD117, Dako Corporation, Carpinteria, CA) for c‐kit protein expression. If present, individuals were then eligible for treatment with an imatinib dose of 400 mg orally twice daily (total, 800 mg per day).RESULTSThe presence of c‐kit protein was assessable in 36 of 39 (92%) tumor samples. Twenty‐eight (78%) tumor samples had immunohistochemical staining for c‐kit protein. Twelve patients were enrolled in the treatment portion of the current study. No responses were observed, and all patients had disease progression by Week 4. Edema, fatigue, nausea, and electrolyte abnormalities were the primary toxicities.CONCLUSIONSImatinib did not have antitumor activity against SCLC, even with c‐kit protein present in tumor specimens. The dismal prognosis for these patients with progressive SCLC emphasized the urgent need for continued studies of new therapies in this population. Cancer 2005. © 2005 American Cancer Society.
Perineural spread of cutaneous malignancy to the brain
Authors: Fowler B. Zach , Crocker Ian R. , Johnstone Peter A. S. 
Published: April 2005

AbstractBACKGROUNDThe retrospective analysis was performed to investigate the role of stereotactic radiotherapy (SRT) techniques for patients with intracranial perineural spread (PNS) of a primary cutaneous malignancy.METHODSFive patients were identified who received SRT from 1993 to 2003 for cutaneous malignancies with intracranial PNS to the cavernous sinus (n = 3) or Meckel's cave (n = 2). Patients were treated with GammaKnife stereotactic radiosurgery (n = 2), linear accelerator (linac)‐based fractionated SRT (n = 2), or linac‐based stereotactic radiosurgery (n = 1).RESULTSThe median overall survival (OS) periods from diagnoses of cutaneous malignancy and intracranial PNS were 63.0 months (range, 22.0–102.2 months) and 25.5 months (range, 22.0–55.2 months), respectively. The median OS from SRT was 24.2 months (range, 19.5–53.2 months). One patient was alive and without evidence of disease at 53 months of follow‐up. The median durations of local and regional control from SRT were 19.5 months (range, 1.5–53.2 months) and 7.0 months (range, 1.5–53.2 months), respectively.CONCLUSIONSPrevious reports generally have recommended that patients with intracranial PNS receive palliative external‐beam radiotherapy. Results from the current study suggest that some of these patients may have prolonged survival, or even may be cured. Judicious use of SRT should be considered in their management. Cancer 2005. © 2005 American Cancer Society.
High‐grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomas
Authors: Alexander Dominik , Jhala Nirag , Chatla Chakrapani , Steinhauer Jon , Funkhouser Ellen , Coffey Christopher S. , Grizzle William E. , Manne Upender 
Published: April 2005

AbstractBACKGROUNDTo identify the factors that contribute to poorer colon carcinoma survival rates for African Americans compared with Caucasians, the authors evaluated survival differences based on the histologic grade (differentiation) of the tumor.METHODSAll 169 African Americans and 229 randomly selected non‐Hispanic Caucasians who underwent surgery during 1981–1993 for first primary sporadic colon carcinoma at the University of Alabama at Birmingham or its affiliated Veterans Affairs hospital were included in the current study. None of these patients received presurgery or postsurgery therapies. Recently, the authors reported an increased risk of colon carcinoma death for African Americans in this patient population, after adjustment for stage and other clinicodemographic features. The authors generated Kaplan–Meier survival probabilities according to race and tumor differentiation and multivariate Cox proportional hazards models to estimate hazard ratios (HR) with 95% confidence intervals (95% CI).RESULTSThere were no differences in the distribution of pathologic tumor stage between racial groups after stratifying by histologic tumor grade. Among patients with high‐grade tumors, 54% of African Americans and 21% of Caucasians died within the first year after surgery (P= 0.007). African Americans with high‐grade tumors were 3 times (HR = 3.05; 95% CI, 1.32–7.05) more likely to die of colon carcinoma within 5 years postsurgery, compared with Caucasians with high‐grade tumors. There were no survival differences by race among patients with low‐grade tumors.CONCLUSIONSThese findings suggested that poorer survival among African‐American patients with adenocarcinomas of the colon may not be attributable to an advanced pathologic stage of disease at diagnosis, but instead may be due to aggressive biologic features like high tumor grades. Cancer 2005. © 2005 American Cancer Society.
Proteins in Action Monitored by Time‐Resolved FTIR Spectroscopy
Authors: Kötting Carsten , Gerwert Klaus 
Published: April 2005

AbstractIn the post genome era proteins coming into the focus of life sciences. X‐ray structure analysis and NMR spectroscopy are established methods to determine the geometry of proteins. In order to determine the molecular reaction mechanism of proteins, time‐resolved FTIR (trFTIR) difference spectroscopy emerges as a valuable tool. In this Minireview we describe the trFTIR difference spectroscopy and show its application on the light‐driven proton pump bacteriorhodopsin (bR), the photosynthetic reaction center and the GTPase Ras, which is crucial in signal transduction. The main principles of the technique are presented, including a summary of triggering techniques, scan modes and analysis.
Astrocyte‐associated axonal damage in pre‐onset stages of experimental autoimmune encephalomyelitis
Authors: Wang Dongwei , Ayers Margaret M. , Catmull Deanne V. , Hazelwood Lisa J. , Bernard Claude C.A. , Orian Jacqueline M. 
Published: April 2005

AbstractRecent studies of axon–glia and glia–glia communication have emphasized interactivity and interdependence between central nervous system (CNS) components. Concurrently, data from imaging, biochemical, and morphological studies have changed the view of multiple sclerosis (MS) from a neuroinflammatory condition with primary demyelination to one in which cumulative axonal damage drives progression. We therefore studied axonal damage in the context of inflammation and glial responses, from the pre‐clinical to onset stage of murine experimental autoimmune encephalomyelitis (EAE), an established MS model. We report three major findings: (1) the first evidence of axonal injury before significant T‐cell entry into the parenchyma, (3) coincidence of the earliest manifestation of axonal damage and astrocytic responses, and (3) an association between accumulation of axonal and astrocytic changes and specific forms of MS. These data demonstrate the relationship between the initiation of axonal injury and early inflammation. Significantly, we show that, in common with a growing number of neurodegenerative conditions, the pathology of murine EAE is characterized by early active contribution from astrocytes. This marks a change in the understanding of the role of astrocytes in MS pathogenesis and has important implications for the development of neuroprotective strategies. © 2005 Wiley‐Liss, Inc.
Pigment epithelium‐derived factor induces the production of chemokines by rat microglia
Authors: Takanohashi Asako , Yabe Takeshi , Schwartz Joan P. 
Published: April 2005

AbstractMany studies have shown that pigment epithelium‐derived factor (PEDF) has neurotrophic effects on retinal cells and hippocampal, spinal cord, and cerebellar granule cell neurons, but much less work has examined the effects of PEDF on glia. In this study, we show that PEDF changes microglial morphology within 1 h of exposure, to a more deactivated form, while having no effect on the expression of such activation markers as OX‐42 and ED‐1. In contrast, urea activates acid phosphatase, and PEDF blocks that activation. PEDF also activates NFκB, accompanied by the induction of mRNAs and proteins for the chemokines macrophage inflammatory protein‐1α (MIP‐1α, MIP‐2, and MIP‐3α. All the chemokines stimulate acid phosphatase activity, and high doses of MIP‐2 and MIP‐3α), alter the morphology of the microglia at 1 h after treatment. These results suggest that the use of PEDF for clinical treatments, such as for retinal neovascularization, brain injury, or ischemia, should be undertaken with caution because of the possibility of induction of inflammation caused by microglial or other immune cell migration in response to the chemokines induced by PEDF. © 2005 Wiley‐Liss, Inc.