bluuebunny/crossref_metadata_2025_split huggingface dataset:
CASE REPORT – EFFORT HEADACHE WITH CEREBRAL INFARCTION
Authors: Seelinger Don F. , Coin Gene C. , Carlow Thomas J. 
Published: June 2005

SYNOPSISA 26 year old man ran a distance of 11/2 miles in 12 minutes. Soon after this effort he developed visual disturbances in the right field of vision and left‐sided clumsiness associated with left frontal headache, nausea and vomiting. Four vessel arteriography and skull x‐rays were normal but examination of the visual fields showed a right superior quadrantic field defect and the electroencephalogram a left posterior temporal slow focus. EMI scan performed a few days later showed an infarct in the left inferior occipital pole. No known risk factors for stroke were present. It is suggested that the cerebral infarction associated with headache was related to effort at altitude and most importantly to lack of physical training.
TRANSIENT ABNORMALITY ON RADIONUCLIDE CEREBRAL DYNAMIC STUDY DURING A MIGRAINE ATTACK
Authors: Szikals John J. , Spencer Richard P. 
Published: June 2005

SYNOPSISA 26 year old man ran a distance of 11/2 miles in 12 minutes. Soon after this effort he developed visual disturbances in the right field of vision and left‐sided clumsiness associated with left frontal headache, nausea and vomiting. Four vessel arteriography and skull x‐rays were normal but examination of the visual fields showed a right superior quadrantic field defect and the electroencephalogram a left posterior temporal slow focus. EMI scan performed a few days later showed an infarct in the left inferior occipital pole. No known risk factors for stroke were present. It is suggested that the cerebral infarction associated with headache was related to effort at altitude and most importantly to lack of physical training.
AN UNEXPECTED EFFECT OF SEROTONIN ANTAGONISTS ON THE CANINE NASAL CIRCULATION
Authors: Schönbaum E. , Vargaftig B.B. , Lefort J. , Lamar J.C. , Hasenack T. 
Published: June 2005

SYNOPSISThe effects of several drugs usually considered as serotonin (5HT) ‐antagonists were studied in a model of the external carotid circulation, the canine nasal vascular bed. 1. It was confirmed that 5‐HT constricts this vascular bed but that after administration of a large dose of ergotamine (10–2 mg/kg i.v.), 5‐HT dilates the nasal vessels. 2. All drugs studied (Org GB 94, Org GC 94, ergotamine, dihydroergotamine, methysergide, pizotifen, cyproheptadine and clonidine) at relatively low concentrations can potentiate 5‐HT induced vasoconstriction. 3. At higher doses of these drugs the 5‐HT response is inhibited.4. The vasodilator response to 5‐HT obtained in erotamine‐treated dogs is inhibited by all other agents investigated.
FOOD INTAKE PRIOR TO A MIGRAINE ATTACK ‐STUDY OF 2,313 SPONTANEOUS ATTACKS
Authors: Dalton Katharina 
Published: June 2005

SYNOPSISSandler, Youdim and Hannington noted an inability to oxidise tyramine and phenylethylamene in dietary and non dietary migraine sufferers‐l,883 female volunteers in Britain completed questionnaires detailing food intake during the 24 hours prior to spontaneous migraine attacks. Analysis of 2,313 attacks are reported. This revealed consumption of chocolate in 33%, cheese 40%, citrus fruits 21% and alcohol 23%. Fasting (5 hours day or 13 hours overnight) occurred in 67%. No dietary factors were isolated in 5%. Only 14% thought food caused their attacks and 2% blamed fasting. Sensitising factors analysed included age, time in menstrual cycle, pill taking and hysterectomy. The findings suggest that in double blind trials designed to elucidate dietary factors, one needs to consider the patient's intake during the 24 hours prior to the administration of the test capsule. A new approach to treatment is suggested with elimination of specific foods and avoidance of fasting.
HEADACHES IN PATIENTS WITH TRANSIENT ISCHEMIC ATTACKS
Authors: Medina Jose L. , Diamond Seymour , Rubino Frank A. 
Published: June 2005

SYNOPSISThirty‐four patients with transient ischemic attacks (TIA) have been followed for 1 to 24 months. Twenty‐two patients had TIA in the anterior and 12 in the posterior circulation. Episodic and late onset vascular headaches occurred. Four patients had episodic headaches, 7 patients had late onset vascular headaches and 11 patients had both types of headaches. Episodic headaches preceded, occurred during, or immediately after TIA. These headaches were present in 15 of the patients (44%). Late onset vascular headaches started in middle or late life, occurred independently of TIA and were observed in 18 patients (52.9%). In 13 patients the headaches began 1 month to 15 years prior to TIA and in 5 cases, 2 days to 1year after the onset of TIA. Late onset vascular headaches preceded TIA in 38.2% of patients. These headaches might be of prognostic significance in some patients for the development of TIA and stroke.
HEADACHE IN SMALL VESSEL DISEASE OF THE BRAIN: A STUDY OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Atkinson Ruth A. , Appenzeller Otto 
Published: June 2005

SYNOPSISSeventy‐two records of patient with systemic lupus erythematosus were reviewed retrospectively. Sixty‐one fulfilled the criteria for the disease. Forty‐six percent had clinical evidence of central nervous system involvement. The incidence of headache was compared in those with and without central nervous system lupus. No difference in the frequency of headache in the two groups were found and the incidence of hypertension, renal disease and steroid therapy was equally distributed among those with and without headache. A significantly higher incidence of hypertension was found in patients with central nervous system lupus erythematosus. We conclude that headache in systemic lupus erythematosus in the absence of neurologic symptoms or signs is no indication of central nervous system involvement by the process and that small vessel disease of the brain is not a cause of headache.
DOUBLE BLIND STUDY OF CLONIDINE AND PLACEBO FOR THE PROPHYLACTIC TREATMENT OF MIGRAINE
Authors: Ryan Robert E. , Diamond Seymour , Ryan Robert E. 
Published: June 2005

SYNOPSISClonidine was evaluated in the prophylactic treatment of migraine. The results were compared with those obtained with placebo in the same patients.Identical protocols were used at headache centers in St. Louis and Chicago. There were similar results though evaluations were completely independent.Clonidine was not superior to placebo in preventing migraine attacks.
SEVERE HEADACHE AFTER CAROTID ENDARTERECTOMY
Authors: Leviton Alan , Caplan Louis , Salzman Edwin 
Published: June 2005

SYNOPSISA woman developed severe recurrent headache associated with transient neurologic dysfunction while recuperating from carotid endarterectomy performed for transient ischemic attacks. She had severe carotidstenosis preoperatively, but when studied during the period of severe headache had an angiographically normal carotid artery territory. The headaches and neurologic dysfunction appeared after a postoperative headache free period of 72 hours, were self limited, and had characteristics of migraine. Migrainous post‐endarterectomy headache may be a manifestation of disordered autoregulation of cerebral blood flow.
ISOMETHEPTENE‐A NON‐ERGOT DRUG IN THE TREATMENT OF MIGRAINE
Authors: Diamond Seymour , Medina Jose L. 
Published: June 2005

SYNOPSISThirty‐six patients participated in a double‐blind, two‐way crossover study of isometheptene (Octin) and placebo. Seventeen had a better response on isometheptene than on placebo. Placebo was superior to isometheptene in eight cases. Of 72 courses of treatment with each drug, isometheptene produced good or complete relief of pain in 30 courses of treatment (42%) while placebo produced a similar response in 21courses of treatment (29%) (p<0.05). When the severity of pain and the degree of relief were considered, the superiority of isometheptene did not reach statistical significance at the 5% level. Side effects due to isometheptene were few and mild or of moderate severity. Isometheptene may be an alternative treatment when ergotamine is contraindicated.
MIGRAINE AND ORAL CONTRACEPTIVES
Authors: Dalton Katharina 
Published: June 2005

SYNOPSISTo ascertain the effect of oral contraceptives on migraine, an analysis was made of self administered questionnaires from 886 non‐pregnant migraine sufferers aged 15‐45 years (241 Pill takers, 290 ex‐takers and 355 non‐takers), together with a 3 months record of migraine attacks in 416 women covering 1,239 menstruations.Migraine was worse on the Pill in 34% of takers and 60% of ex‐takers. On stopping the Pill 39% of ex‐takers improved. During menstruation 35% of attacks occurred in takers, 32% of attacks in ex‐takers and 27% of attacks in non‐takers. A significant increase in migraine at mid‐cycle was most marked among those whose migraine increased on the Pill and those with severe attacks. Other significant differences are reported relating to length of menstrual cycle. Deterioration of migraine on Pill related to age, parity, cycle length, menstrual attacks, relief of migraine in late pregnancy and onset after pregnancy.
HEAD PAIN: CONGENITAL, ANATOMICAL, PATHOLOGICAL AND NEUROSURGICAL CORRELATES
Authors: TRUPP MASON 
Published: June 2005

SYNOPSISThe neurosurgical findings and neuropathological confirmation of symptomatic congenital constriction of the superior sagittal sinus 4 cm rostral to the torcular Herophili is reported. This was caused by infantile occipital parietal overlap in 21 cases of intractable migraine. The constriction of the superior sagittal sinus is initiated during parturition and results in an atresia and post stenotic dilatation of the sinus which leaves its specific imprint in man's occiput. Turbulence within this segment of the sinus is perceived in the trigeminal sensory nerve distribution. Fontanel craniectomy appears to yield relief of head pain in intractable migraine and in persistent pseudotumor cerebri.
REGIONAL CEREBRAL BLOOD FLOW IN THE DIAGNOSIS OF VASCULAR HEADACHE
Authors: Mathew Ninan T. , Hrastnik Franc , Meyer John S. 
Published: June 2005

SYNOPSISPotential availability of a reliable non‐invasive system for measuring regional cerebral blood flow (rCBF)prompted measurement of rCBF in patients with vascular headache in order to assess its diagnostic value.The rCBF in migraine varied with the clinical phase. During the prodrome phase the blood flow was reduced; whereas during the headache phase, a striking cortical hyperperfusion was noted. Patients who continued to have neurologic symptoms of the prodrome in the headache phase showed a mixed pattern of reduced and increased blood flow.The rCBF was found normal in the headache phase in patients with muscle contraction and psychogenic headache.In patients with headache as a prominent symptom of cerebrovascular insufficiency, rCBF was reduced but was not significantly different from rCBF in patients with cerebrovascular insufficiency without headache.
“CEPHALGIC” SPASM OF HEAD AND NECK MUSCLES
Authors: Pozniak‐Patewicz Ewa 
Published: June 2005

SYNOPSISElectromyographic examinations of neck and temporal muscles were performed in 132 patients with various types of headaches and in 51 controls. No muscle action potentials were found provided control subjects were voluntarily relaxed. The majority of headache patients though voluntarily relaxed showed continous electrical activity in muscles resulting from sustained spasm. This phenomenon seems to be characteristic for headache patients. It is named “cephalgic” spasm of head and neck muscles. “Cephalgic” spasm is thought to be a consequence rather than the cause of headache.
AUTOGENIC FEEDBACK TRAINING IN MIGRAINE: A TREATMENT REPORT
Authors: Mitch Paul S. , McGrady Angele , Iannone Anthony 
Published: June 2005

SYNOPSISTwenty migraine patients were treated with a Biofeedback technique termed “Autogenic Feedback Training.” This involved offering patients a method by which they could raise their hand temperature using Autogenic Phrases combined with temperature feedback via an electronic thermometer. Headache duration, frequency, intensity and medication need were evaluated. Half the patients were evaluated six months after the end of treatment. The treatment period was compared with the prior six months. Patients with uncomplicated migraine were successful and those with mixed migraine and tension headaches were not. At follow‐up improvement was maintained. Autogenic Feedback training is an effective technique for migraine but in presence of tension headache EMG feedback and/or counseling may also be necessary.
MIGRAINE AND ATOPY
Authors: Medina Jose L. , Diamond Seymour 
Published: June 2005

SYNOPSISThe relation of migraine to atopy was studied. 89 cases of migraine and 27 muscle contraction headache has serum IgE levels determined. In addition, 504 patients were questioned about personal and family history of atopy. There were 73 muscle contraction headache, 55 cluster headache, 70 classical migraine, 189 common migraine and 117 mixed muscle contraction and migraine headache in this group. Elevated serum IgE levels were found in 5.7% of migraine and 3.7 % of muscle contraction headache patients. The incidence is not significantly different from non‐atopic general population. The prevalence of atopic disorders in migraine patients and their relatives did not differ from that found in patients with muscle contraction headache. This study does not support the concept that migraine is an IgE‐mediated hypersensitivity state.
THERAPEUTIC EFFECT OF RESERPINE ON MIGRAINE SYNDROME: RELATIONSHIP TO BLOOD MINE LEVELS
Authors: Fog‐Míller F. , Bryndum B. , Dalsgaard‐Nielsen T. , Genefke I. Kemp , Nattero G. 
Published: June 2005

SYNOPSISTen migraineurs volunteered for intravenous in actions of reserpine over a period of six weeks. The clinical effects were noted and blood specimens were analyzed for norepinephrine, epinephrine and erotonin for twelve weeks.The frequency and intensity of migrainous attacks was decreased in this open trial. A marked decrease in concentration of blood amines which accompanied clinical improvement was found.
RESERPINE FOR MIGRAINE PROPHYLAXIS
Authors: Nattero G. , Lisino F. , Brandi G. , Gastaldi L. , Genefke I. Kemp 
Published: June 2005

SYNOPSISBecause of the role of monoamines in the genesis of migraine and the pharmacologic action of reserpine, we have used this substance in prophylactic treatment of migraine for 10 years on 300 patients.1Intravenously administered reserpine in a dose of 0.2 mg every second or third day for a period of 6‐8 weeks was employed. Statistically significant improvement in severe migraine was obtained. A double blind clinical trail of this method of therapy carried out in Turin and Copenhagen confirmed the efficacy of reserpine in the treatment of severe migraine if given in appropriate doses. No side effects were observed. It is suggested that the intravenous administration at regular intervals of small doses of reserpine depletes norepinephrine and/or serotonin, these vasoactive substances are not released at the time of a migrainous attack.
TREATMENT OF MIGRAINE WITH ISOMETHEPTENE, ACETAMINOPHEN, AND DICHLORALPHENAZONE COMBINATION: A DOUBLE‐BLIND, CROSSOVER TRIAL
Authors: Diamond Seymour 
Published: June 2005

SYNOPSISForty female and 16 male adult migraineurs were subjects in a double‐blind, three‐way crossover trial to compare the effectiveness and safety of isometheptene mucate, acetaminophen, and dichloralphenazone combination (Midrin) with that of acetaminophen alone and of placebo. Forty‐three patients had common migraine and 13 had classic migraine. Each subject and the investigator evaluated the effectiveness of medication in 6 headache episodes (two replications of each test medication); subjects also rated peak headache severity for each of the six episodes. For subjects' evaluations of relief and headache severity and investigator's assessments of relief, the isometheptene combination proved superior (P<0.05). The least number of capsules was taken during episodes for which the isometheptene combination was the test medication. Other known headache medications were also taken least during isometheptene combination tests. This suggests greater effectiveness of isometheptene combination therapy. Nausea and vomiting occurred in association with ten isometheptene combination, 7 acetaminophen and 18 placebo episodes. Other untoward effects of test meditation were mild and reversible and were also frequently associated with placebo medication.
PREVALENCE OF MIGRAINE AND OTHER HEADACHE IN FINNISH CHILDREN STARTING SCHOOL
Authors: Sillanpåå Matti 
Published: June 2005

SYNOPSISThe prevalence of migraine and other headaches are assessed in Finnish seven year old school children. Four thousand two hundred thirty‐five children were examined. 37.7% had headaches before starting school. Initially headaches occurred occasionally and were most often associated with febrile episodes. 3.2% of children had migraine.
HEADACHE RESEMBLING CLUSTER HEADACHE (HORTON'S HEADACHE), WITH RECURRING BOUTS OF HOMOLATERAL RETROBULBAR NEURITIS, PARTIAL FACTOR XII DEFICIENCY, BLEEDING TENDENCY AND A HETEROLATERAL CONVULSIVE EPISODE
Authors: Sjaastad O. , Hørven I. , Vennerød Anne Marie 
Published: June 2005

SYNOPSIS A 42 year old woman had 3 cluster epidoses which were associated with longlasting ipsilateral retro‐bulbar neuritis. The temporal and spatial relationship between cluster headache and retro‐bulbar neuritis in this patient suggests a casual relationship between these phenomena. One cluster headache paroxysm was associated with a convulsive episode in the contralateral lower extremity.The patient, her father, and her 3 sons had an increased bleeding tendency. In each a lowered factor XII level was present, but only the patient had headache and slightly reduced plasma pre kallikrein levels. The headache reported might be distinct from cluster headache.
CLUSTER HEADACHE AND BRADYCARDIA
Authors: Bruyn G.W. , Bootsma B.K. , Klawans H.L. 
Published: June 2005

SYNOPSIS A case of classic cluster headaches associated with paroxysmal bradycardia and hypertension is presented. This case suggests that dysfunction in the medulla oblongata is the primary event in cluster headache. A preliminary hypothesis is discussed which attributes the pathogenesis of cluster headache to a burst of increased central a‐adrenergic activity while migraine involves an analogous burst of b‐adrenergic activity.
SEROTONIN (5HT) IN MIGRAINE: LEVELS IN WHOLE BLOOD IN AND BETWEEN ATTACKS
Authors: Rydzewski Wladyslaw 
Published: June 2005

SYNOPSIS Fluorimetric estimations of total 5HT in blood of 11 migrainous patients during an untreated migraine attack were made. Total blood 5HT dropped during a migraine attack to about 68% of its former level returning to preheadache values by the time the pain ceased. Mean values for total blood serotonin (ng/ml) were 65.1 at the beginning of a migraine attack, 57.9 at the peak, 61.0 at the end, and 91.2 in the headache free period (p<0.05). No correlation between the intensity of the headache and the concentration of 5HT during a migraine attack was found (p>0.5). The influence of some drugs upon fluorescence in blood of migraineurs was tested.
WHAT IS PSYCHOGENIC HEADACHE?
Authors: Packard Russell C. 
Published: June 2005

SYNOPSIS The purpose of this study was to explore the question of "What is psychogenic headache?" The literature was reviewed and a survey was conducted among physicians at the National Naval Medical Center in Bethesda, Maryland, asking them to define psychogenic headache. There were 105 responses, representing a wide consensus of opinion about definition. From the literature and data from this survey it is concluded that the term "psychogenic headache" is not precise nor diagnostic. A definition is proposed based on criteria of the American Medical Association Ad Hoc Commitee on Classification of Headache.
DOUBLE BLIND STUDY OF PROPRANOLOL FOR MIGRAINE PROPHYLAXIS
Authors: Diamond Seymour , Medina Jose L. 
Published: June 2005

SYNOPSIS Eighty‐three migraine patients were admitted to a double‐blind, single cross‐over, propranolol vs. placebostudy. Sixty‐two patients completed the trial. The daily dosage was either 80 or 160 mg. propranolol, or an equivalent number of placebo capsules, for 4 to 8 weeks for the first medication and 8 weeks for the second one. At the end of the trial, 32 patients preferred propranolol and 18 placebo. Those who preferred propranolol had greater reduction in severity and frequency of headaches and less consumption of analgesics and ergotamine than patients who preferred placebo. Side effects were benign. Propranolol issafe and effective for the prophylaxis of migraine if patients are carefully selected.
PLASMA TESTOSTERONE LEVELS IN CLUSTER HEADACHE PRELIMINARY RESULTS
Authors: Kudrow Lee 
Published: June 2005

SYNOPSIS Plasma testosterone values were obtained by the RIA method from two groups of cluster headache male patients in separate laboratories. In each group testosterone levels were compared between controls and cluster patients in active and remission periods. Significantly lower values were found in active cluster patients when compared to either cluster‐remission or controls. The results are preliminary and suggest a possible association of lowered plasma testosterone levels with active cluster period in cluster headache male patients.
MIGRAINE, TYRAMINE AND BLOOD SEROTONIN
Authors: Ziegler Dewey K. , Hassanein Ruth Stephenson , Ward Daniel F. 
Published: June 2005

SYNOPSIS Whole blood serotonin levels and headache symptoms were studied in 26 migrainous patients during a three day period with administration of tyramine the first day, reserpine the second day. No significant changes in serotonin occurred after tyramine; headache severity was not associated with change in blood serotonin, which dropped to low levels after a small dose of reserpine without precipitating migraine in most patients.
PLASMA FREE FATTY ACIDS AND PROSTAGLANDIN E1 IN MIGRAINE AND STRESS
Authors: Anthony Michael 
Published: June 2005

SYNOPSIS The relationship of plasma FFA, plasma PGE1 and platelet serotonin changes were investigated in migrainous patients and in patients subjected to stressful procedures.Plasma FFA levels rose and platelet serotonin content fell during the migrainous episode in the majority of patients. These changes were statistically significant. Plasma FFA levels and platelet serotonin changed reciprocally in 60% of cases. No statistically significant change in plasma FFA levels were observed in patients subjected to stressful procedures or during cluster headache.Plasma levels of PGE1 showed no significant change during migraine. No difference in PGE1 between venous and arterial plasma was found in normal subjects and in patients with various neurologic diseases. Plasma levels of natural PGE1 do not accurately reflect the rate of PGE1 synthesis in the body and this may account for these negative results.The migraine attack is accompanied by a rise in plasma FFA. However, this rise is not necessarily the cause for serotonin release which occurs during migraine. Both the amine and PGE1 could release FFA from body stores. Identification of the individual FFA released would be necessary to resolve the problem. The role of PGE1 in migraine, might be assessed by estimation of its more stable 15‐keto‐dihydro metabolite which reflects more accurately its rate of synthesis. This could demonstrate whether PGE 1 plays a part in the biochemical process of headache.
BIOFEEDBACK‐ALLEVIATED HEADACHES: A FOLLOW‐UP
Authors: Montgomery Penelope S. , Ehrisman Wayne J. 
Published: June 2005

SYNOPSIS Twenty‐two follow‐up questionnaires were sent to persons who completed a program of biofeedback and relaxation for the relief of headache. Thirteen questionnaires were returned. The follow‐up ranged from six months to three years. Frequency, severity and duration of headaches were assessed before training, at the end of training and at follow‐up. Statistically significant symptom reduction endured although some increase in symptoms occurred in the period between the end of treatment and follow‐up.