bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating animal tracking data into spatial conservation prioritisation for seabirds during their breeding season
Authors: Venegas-Li Ruben , Chiaradia Andre , Schinagl Harley , Kato Akiko , Ropert-Coudert Yan , Possingham Hugh , Reina Richard D. 
Published: December 2023

AbstractUnderstanding the spatial-temporal marine habits is crucial to conserving air-breathing marine animals that breed on islands and forage at sea. This study, focusing on little penguins from Phillip Island, Australia, employed tracking data to identify vital foraging areas during breeding season. Long-term data from sub-colonies and breeding stages were analysed using 50%, 75%, and 90% kernel utilisation distributions (KUDs). Breeding success, classified as low, average, or high, guided the exploration of site, year, and breeding stage-specific habitats. Using Marxan, a widely used conservation planning tool, the study proposes both static and dynamic spatial-temporal scenarios for protection based on KUDs. The dynamic approach, requiring less space than the static strategy, was more efficient and likely more acceptable to stakeholders. The study underscores the need for comprehensive data in conservation plans, as relying on one nesting site’s data might miss essential foraging areas for penguins in other locations. This study demonstrates the efficacy of animal tracking data in spatial conservation prioritisation and marine spatial planning. The dynamic areas frequented emerged as a strategy to safeguard core regions at sea, offering insights to improve the conservation of iconic species like little penguins and promoting the health of islands and the entire marine ecosystem.
Development of an automated high-content immuno-fluorescence assay of pSmads quantification: proof-of-concept with drugs inhibiting the BMP/TGFβ pathways
Authors: Khodr Valia , Clauzier Laura , Machillot Paul , Sales Adrià , Migliorini Elisa , Picart Catherine 
Published: December 2023

AbstractBone morphogenetic proteins (BMPs) and transforming growth factors (TGF-β) are members of the transforming growth factors superfamily, known for their role in several physiological and pathological processes. These factors are known to bindin vivoto BMP and TGF-β receptors respectively, which induces the phosphorylation of the Smad (pSmad) transcription factors. This pathway is generally studied with western blot and luciferase bioluminescence assay, which present some limitations. In our work, we developed and optimized a high-content immunofluorescence assay to study the pSmad pathway on glass as well as on biomaterials by overcoming the technical challenges raised by image acquisition and analysis. Furthermore, with this assay, we present here a proof-of concept for drug testing on glass and on biomimetic films using drug inhibitors of the BMP receptor and of the TGF-β receptors. Altogether, our results open perspectives for future drug testing on biomimetic films that present various growth factors and extracellular matrix proteins or peptides.
Structural basis of a regulatory switch in mammalian complex I
Authors: Grba Daniel N. , Wright John J. , Yin Zhan , Fisher William , Hirst Judy 
Published: December 2023

SummaryRespiratory complex I powers oxidative phosphorylation in mammalian mitochondria by using the reducing potential of NADH to reduce ubiquinone-10 and drive protons across the inner mitochondrial membrane. High-resolution cryoEM structures have provided a molecular framework for complex I catalysis, but controversies about how to assign functional properties to the states identified in single-particle analyses are preventing progress on its energy-converting mechanism. Here, we combine precise biochemical definition with high-resolution cryoEM structures in the phospholipid bilayer of coupled vesicles and show that the closed and open states observed in mammalian complex I preparations are components of the deactive transition that occurs during ischaemia. Populations of the cryoEM open state and biochemical deactive state match exactly. Deactivation switches the enzyme off, converting the closed state that is capable of rapid, reversible catalysis into an open, dormant state that is unable to start up in reverse. The deactive state is switched back on by slow priming reactions with NADH and ubiquinone-10. Thus, by developing a versatile membrane system to unite structure and function, we define the role of large-scale conformational transitions in complex I and establish a new gold standard for structure-based investigations of catalysis by energy-coupled proteins.
Multi-layered proteomics identifies insulin-induced upregulation of the EphA2 receptor via the ERK pathway and dependent on low IGF1R level
Authors: Jørgensen Sarah Hyllekvist , Emdal Kristina Bennet , Pedersen Anna-Kathrine , Axelsen Lene Nygaard , Kildegaard Helene Faustrup , Damozay Damien , Pedersen Thomas Åskov , Grønborg Mads , Slaaby Rita , Nielsen Peter Kresten , Olsen Jesper Velgaard 
Published: December 2023

AbstractInsulin resistance impairs the cellular insulin response and frequently precedes metabolic disorders, like type 2 diabetes, which are affecting an increasing number of people globally. Given the critical role of the liver in glucose and lipid metabolism, understanding the molecular mechanisms in hepatic insulin resistance is essential for early preventive treatments. To elucidate changes in insulin signal transduction associated with hepatocellular resistance, we employed a multi-layered mass spectrometry-based proteomics approach focusing on insulin receptor (IR) signaling at the interactome, phosphoproteome, and proteome levels.in a long-term hyperinsulinemia-induced insulin-resistant HepG2 cell line with a knockout of the insulin-like growth factor 1 receptor (IGF1R KO). Analysis of the dynamic insulin-induced IR interactome revealed recruitment of the PI3K complex in both insulin-sensitive and -resistant cells. From the phosphoproteomics dataset, a change in insulin-stimulated signaling responses in insulin resistance was observed and showed attenuated signaling via the metabolic PI3K-AKT pathway but sustained extracellular signal-regulated kinase (ERK) activity. At the proteome level, the ephrin type-A receptor 2 (EphA2) showed an insulin-induced increase in expression. This receptor belongs to the Eph receptor family and participates in various cellular processes, such as cell adhesion, migration, and tissue development. The protein abundance regulation of EphA2 occurred through the ERK signaling pathway and was concordantly independent of insulin resistance. Induction of EphA2 by insulin was confirmed in other cell lines and observed uniquely in cells with high levels of IR compared to IGF1R. The multi-layered proteomics dataset provided insights into insulin signaling in general and in the context of insulin resistance, and it can going forward serve as a resource to generate and test hypotheses, leading to an improved understanding of insulin resistance.
A Stochastic Population Model for the Impact of Cancer Cell Dormancy on Therapy Success
Authors: Blath Jochen , Kraut Anna , Paul Tobias , Tóbiás András 
Published: December 2023

AbstractTherapy evasion – and subsequent disease progression – is a major challenge in current oncology. An important role in this context seems to be played by various forms of cancer cell dormancy. For example, therapy-induced dormancy, over short timescales, can create serious obstacles to aggressive treatment approaches such as chemotherapy, and long-term dormancy may lead to relapses and metastases even many years after an initially successful treatment. The underlying dormancy-related mechanisms are complex and highly diverse, so that the analysis even of basic patterns of the population-level consequences of dormancy requires abstraction and idealization, as well as the identification of the relevant specific scenarios.In this paper, we focus on a situation in which individual cancer cells may switch into and out of a dormant state both spontaneously as well as in response to treatment, and over relatively short time-spans. We introduce a mathematical ‘toy model’, based on stochastic agent-based interactions, for the dynamics of cancer cell populations involving individual short-term dormancy, and allow for a range of (multi-drug) therapy protocols. Our analysis shows that in our idealized model, even a small initial population of dormant cells can lead to therapy failure under classical (and in the absence of dormancy successful) single-drug treatments. We further investigate the effectiveness of several multidrug regimes (manipulating dormant cancer cells in specific ways) and provide some basic rules for the design of (multi-)drug treatment protocols depending on the types and parameters of dormancy mechanisms present in the population.
Collective impact for ocean literacy – inspiring the next generation of ocean champions using social marketing
Authors: McHugh Patricia , Dromgool-Regan Cushla , Domegan Christine T. , Burke Noirin 
Published: December 2023

Purpose
This paper aims to describe a case between practitioners and social marketing academics to grow and scale a programme that engages with primary schools, teachers, children and the education network, inspiring students to become marine leaders and ocean champions.

Design/methodology/approach
Over a six-year period, the authors first applied collective intelligence to work with stakeholders across society to better understand the barriers and solutions to teaching children (6–12 year olds) about the ocean in schools. Following this, a Collective Impact Assessment of the Explorers Education Programme took place to grow the impact of the programme.

Findings
The Explorers Education Programme has grown its numbers higher than pre-pandemic levels. In 2022, the Explorers Education Programme had the largest number of participating children, reaching 15,237, with a growth of 21% compared to pre-pandemic levels in 2019 and 79% compared to 2021. In 2023, the programme won the “Best Education Outreach Award” category of the Education Awards in Ireland.

Research limitations/implications
This research stresses the importance of measuring impact. The long-term impact of the Explorers Education Programme at societal, environmental and economical levels takes a much longer time frame to measure than the six years of these research collaborations.

Practical implications
The collaborative approach between academics and practitioners meant that this research had practical implications, whereby necessary and effective changes and learnings could be directly applied to the Explorers Education Programme in real time, as the practitioners involved were directly responsible for the management and coordination of the programme.

Originality/value
The value of collaborations and engagement between academia and practice cannot be underestimated. The ability to collectively reflect and assess impact moves beyond “an” intervention, allowing for more meaningful behavioural, social and system changes for the collective good, inspiring the next generation of marine leaders and ocean champions.
Social entrepreneurship and complex thinking: an exploratory, educational innovation proposal for acquiring and scaling competencies
Authors: Vázquez-Parra José Carlos , Cruz-Sandoval Marco , Sotelo Carlos , Sotelo David , Carlos-Arroyo Martina , Welti-Chanes Jorge 
Published: December 2023

PurposeThis article aims to present the results of an exploratory pilot study that demonstrates the validity of a self-created implementation methodology to develop the students' level of perceived achievement of the social entrepreneurship competency and explain how this is equally valid in developing the perceived achievement of the complex thinking competency.Design/methodology/approachBased on a multivariate descriptive statistical analysis, this article offers the results of an educational intervention carried out on a sample group of students from a Mexican university before and after a training program in social entrepreneurship.FindingsThe favorable results showed that the proposed methodology is valid for scaling social entrepreneurship and complex thinking competencies and their subcompetencies.Originality/valueThese results are not only academically valuable, as they highlight the need to delve into the relationship between these two competencies, but they also allow us to appreciate the ample opportunities for practical implementation of entrepreneurship programs by universities and other institutions to work directly with social entrepreneurs and seek alternatives to develop skills through devising, proposing and developing social entrepreneurship projects.
Developing computational methods of heat flow using bioheat equation enhancing skin thermal modeling efficiency
Authors: Ostadhossein Rouhollah , Hoseinzadeh Siamak 
Published: December 2023

Purpose
The main objective of this paper is to investigate the response of human skin to an intense temperature drop at the surface. In addition, this paper aims to evaluate the efficiency of finite difference and finite volume methods in solving the highly nonlinear form of Pennes’ bioheat equation.

Design/methodology/approach
One-dimensional linear and nonlinear forms of Pennes’ bioheat equation with uniform grids were used to study the behavior of human skin. The specific heat capacity, thermal conductivity and blood perfusion rate were assumed to be linear functions of temperature. The nonlinear form of the bioheat equation was solved using the Newton linearization method for the finite difference method and the Picard linearization method for the finite volume method. The algorithms were validated by comparing the results from both methods.

Findings
The study demonstrated the capacity of both finite difference and finite volume methods to solve the one-dimensional and highly nonlinear form of the bioheat equation. The investigation of human skin’s thermal behavior indicated that thermal conductivity and blood perfusion rate are the most effective properties in mitigating a surface temperature drop, while specific heat capacity has a lesser impact and can be considered constant.

Originality/value
This paper modeled the transient heat distribution within human skin in a one-dimensional manner, using temperate-dependent physical properties. The nonlinear equation was solved with two numerical methods to ensure the validity of the results, despite the complexity of the formulation. The findings of this study can help in understanding the behavior of human skin under extreme temperature conditions, which can be beneficial in various fields, including medical and engineering.
Hiemenz stagnation point flow of a second-order micropolar slip flow with heat transfer
Authors: Usafzai Waqar Khan , Aly Emad H. , Pop Ioan 
Published: December 2023

Purpose
This paper aims to study a non-Newtonian micropolar fluid flow over a bidirectional flexible surface for multiple exact solutions of momentum boundary layer and thermal transport phenomenon subject to wall mass flux, second-order slip and thermal jump conditions.

Design/methodology/approach
The coupled equations are transformed into ordinary differential equations using similarity variables. Analytical and numerical techniques are used to solve the coupled equations for single, dual or multiple solutions.

Findings
The results show that the stretching flow, shrinking flow, the wall drag, thermal profile and temperature gradient manifest large changes when treated for special effects of the standard parameters. The role of critical numbers is definitive in locating the domains for the existence of exact solutions. The nondimensional parameters, such as mass transfer parameter, bidirectional moving parameter, plate deformation strength parameter, velocity slips, material parameter, thermal jump and Prandtl number, are considered, and their physical effects are presented graphically. The presence of governing parameters exhibits special effects on the flow, microrotation and temperature distributions, and various exact solutions are obtained for the special parametric cases.

Originality/value
The originality and value of this work lie in its exploration of non-Newtonian micropolar fluid flow over a bidirectional flexible surface, highlighting the multiple exact solutions for momentum boundary layers and thermal transport under various physical conditions. The study provides insights into the effects of key parameters on flow and thermal behavior, contributing to the understanding of complex fluid dynamics.
Analyzing user sentiments toward selected content management software: a sentiment analysis of viewer’s comments on YouTube
Authors: Saikia Swagota , Kumar Vinit , Verma Manoj Kumar 
Published: December 2023

Purpose
The purpose of this study was to perform sentiment analysis and analyze the growth and popularity of Drupal, Joomla and WordPress on YouTube over a four-year period. This included identifying the most liked and commented videos for each content management system (CMS), ranking the CMSs based on the number of positive comments they received, and using natural language processing techniques to identify the top ten most frequently appearing words in videos about the CMSs.

Design/methodology/approach
The data for assessing the features of the videos of Drupal, WordPress and Joomla was extracted using Webometric Analyst version 4.4. with the help of the YouTube application programming interface key for videos on the selected CMSs uploaded from 2019 to 2022. The extraction of comments and sentiment analysis for the relevant videos was done using Mozdeh.

Findings
This study scrutinized 371, 234 and 313 videos of WordPress, Joomla and Drupal on YouTube. The findings reveal that there is a chronological growth of videos of the three CMSs in four years and till the present time, WordPress has the highest number of videos followed by Drupal and then Joomla. Regarding the ranking of highly liked videos, WordPress again wins the list with the highest number of likes in its videos followed by Drupal and then Joomla. For analyzing sentiments of the total comments extracted 123,409 for WordPress, 1,790 for Joomla and 1,783 for Drupal, respectively, WordPress receives the highest average positive comments followed by Drupal then Joomla. In top word frequency, the word “thank” highly occurs and viewers are asking for more tutorial videos.

Originality/value
To the best of the authors’ knowledge, this study is the first attempt for analyzing the sentiments of WordPress, Drupal and Joomla using Mozdeh software within the concerning period.
Research trends in the field of Islamic social finance: a bibliometric analysis from 1914 to 2022
Authors: Akhter Afaf , Javed Mohd Yousuf , Akhter Javaid 
Published: December 2023

Purpose
This study aims to present a bibliometric analysis of Islamic social finance (ISF) by addressing gaps in the existing research, exploring the current trends of publications and determining possible future research directions in this field.

Design/methodology/approach
Relevant bibliometric data of published research during 1914–2022 was extracted from the Scopus database and 1,355 studies were considered for the analysis. Biblioshiny app from RStudio, VOSviewer and Microsoft Excel were the tools used for analysis.

Findings
The identified current research streams are management and distribution of ISF funds especially zakat through fintech; governance and accountability of ISF institutions; Islamic microfinance for poverty alleviation and financial inclusion; ISF for promoting sustainable development and achieving United Nations sustainable development goals; waqf endowments and cash waqf; and Islamic charities. The identified themes for future research directions are Islamic fintech, integration of ISF, sustainable development, economic recovery, social entrepreneurship, sustainable ISF ecosystem and supporting refugees.

Practical implications
It provides extensive and up-to-date literature on the current trends in ISF and future research themes which can be useful for researchers, professionals and policymakers in the field.

Social implications
The findings of this research contribute to the solutions to socio-economic challenges and support sustainable development through ISF.

Originality/value
To the best of the authors’ knowledge, this research is one of the first attempt to provide a pervasive bibliometric review on ISF by including various aspects of ISF and extending the study period to more than 100 years.
Exploring the mechanical response of functionally graded hollow disks: insights from rotation, gravity and variable heat generation
Authors: Singh Sanjay Kumar , Sondhi Lakshman , Sahu Rakesh Kumar , Madan Royal 
Published: December 2023

PurposeThe purpose of the study is to perform elastic stress and deformation analysis of a functionally graded hollow disk under different conditions (rotation, gravity, internal pressure, temperature with variable heat generation) and their combinations.Design/methodology/approachThe classical method of solution, Navier's equation, is used to solve the governing equation. The analysis considers thermal and mechanical boundary conditions and takes into account the variation of material properties according to a power law function of the radius of the disk and grading parameter.FindingsThe findings of the study reveal distinct trends and behaviors based on different grading parameters. The influence of gravity is found to be negligible, resulting in similar patterns to the pure rotation case. Variable heat generation introduces non-linear temperature profiles and higher displacements, with stress values influenced by grading parameters.Practical implicationsThe study provides valuable insights into the behavior of displacement and stresses in hollow disks, offering a deeper understanding of their mechanical response under varying conditions. These insights can be useful in the design and analysis of functionally graded hollow disks in various engineering applications.Originality/valueThe originality and value of this study lies in the consideration of various loading combinations of rotation, gravity, internal pressure and temperature with variable heat generation. Furthermore, the study of effect of various angular rotations, temperatures and pressures expands the understanding of the mechanical behavior of such structures, contributing to the existing body of knowledge in the field.