bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unresectable Leiomyosarcoma Of The Inferior Vena Cava With Right Atrium Tumor Thrombus: When To Deem This Tumor Inoperable? A Case Report And Literature Review.
Authors: Castellanos Luis D. , Tabbara Marina M. , Livingstone Alan S. , Salerno Tomas A. , Gonzalez Javier , Ciancio Gaetano 
Published: September 2023

Abstract
Background
Leiomyosarcomas (LMS) of the inferior vena cava (IVC) are a rare form of retroperitoneal malignancy and their venous extension to the right atrium is an even rarer event. These tumors pose a unique surgical challenge and often require a multidisciplinary team-based approach for their surgical treatment.
Case presentation:
We present a case of a 68-year-old male with primary LMS of the IVC with a tumor thrombus extending into the right atrium that was initially deemed inoperable.
Conclusions
After extensive neoadjuvant chemo-radiation with minimal tumor effect, the patient underwent en-bloc surgical resection of the tumor along with removal of the infrarenal IVC and right kidney and adrenal without the need for cardiopulmonary bypass.
Big Data of Brain-Lung-Heart-Anesthesia via Integrating Transcranial Doppler and Electrocardiogram Monitor for Cardiothoracic Anaesthesia Practice and Research
Authors: Shen Wei , Zang Nailiang , Wang Wei , Liu Jun , Xu Xin , Lan Lan , Liu Zihao , Qing Ai , He Jianxing 
Published: September 2023

Abstract
In the article, dynamic Transcranial Doppler (TCD)application is described to skillfully monitor cerebral blood flow during surgery, differing from the common Bispectral Index (BIS) and cerebral oxygen in the clinic. During cardiothoracic anaesthesia, continuous intracranial hemodynamics is sensitive to operations, anaesthesia depth, and cardiopulmonary and is stably maintained to reduce the risk of cerebral ischemia. The usefulness and limitations are illustrated with examples of the original TCD monitoring Video-Assisted Thoracic Surgery, Lung Transplantation, and Transcatheter Aortic Valve Implantation. The complicated physiopathologic relationship of lung-brain-heart-anesthesia makes it difficult for surgeons and anesthesiologists to regulate cerebral blood flow accurately. The integrated parameters include intraoperative electrocardiogram monitor system and brain multimodal via TCD and Intensive Critical Monitoring (ICM+) software. The core innovation resolves the digital output of the electrocardiogram monitor system to ICM+ and Anesthesia Information Management System to guarantee anaesthetists’ work. The big data recorded per 10 seconds of integrated parameters in ICM+ software helps to explore more research and directly advise anaesthetists and surgeons to reduce post-operative cerebrovascular risk and improve cognitive rehabilitation.
Trial Registration Our study is registered on www.chictr.org.cn, ChiCTR2100052463.
Non-integral boundary slopes of alternating knots
Authors: Ishikawa Masaharu , Mattman Thomas W. , Shimokawa Koya 
Published: September 2023

Abstract

We show, for every positive integer $n$, there is an alternating knot having a boundary slope with denominator $n$. We make use of Kabaya's method for boundary slopes and the layered solid torus construction introducedby Jaco and Rubinstein and further developed by Howie et al.
Platelets as Delivery Vehicles for Targeted Enrichment of NO• to Cerebral Glioma for Magnetic Resonance Imaging
Authors: Ding Yuchen , Ge Min , Yu Juncheng , Xia Donglin , He Jian , Jia Zhongzheng 
Published: September 2023

Abstract
Using a magnetic resonance imaging (MRI) contrast agent, MRI has made substantial contributions to glioma diagnosis. Despite that metal-free MRI agents, such as the nano free radical nitric oxide (NO•), can overcome the toxicity associated with metal-based agents in certain patient populations, however, a low spatial resolution in MRI limits their clinical development. In this study, we pretreated platelets (PLTs) and loaded them with nano NO• particles to synthesize NO•@PLT, which can overcome the low contrast and poor in vivo stability of nitroxide-based MRI contrast agents. The PLTs can serve as potential drug carriers for targeting and delivering nano NO• to gliomas and thus increase the contrast in T1-weighted imaging (T1WI) of MRI. This drug carrier system uses the unique tumor-targeting ability of PLTs and takes advantage of the high signal presentation of steady nano-NO• in T1WI, thereby ultimately achieving signal amplification of glioma in T1WI. Because of its unique ability to target PLT surface proteins, NO•@PLT has per-nitroxide transverse relativities of approximately 2-fold greater than those of free NO•, exceptional stability in highly reducing environments, and low toxicity. These features allow a sufficient NO•@PLT concentration to accumulate in murine subcutaneous glioma tumors up from 5 min to 2.5 h (optimum at 1.5 h) after systemic administration. This results in MRI contrast comparable to that of metal-based agents. This study established a promising metal-free MRI contrast agent, NO•@PLT, for glioma diagnosis, because it has superior spatial resolution owing to its high glioma-targeting ability and has significant translational implications in the clinic.
High-speed rubbing behavior between nickel-based superalloy blades and ceramic-based abradable coatings
Authors: Yang Shuai , Gao Siyang , Xue Weihai , Wu Bi , Zhang Jiaping , Duan Deli 
Published: September 2023

Abstract
The tribological behavior of nickel-based superalloy blades with YSZ ceramic-based abradable coatings was investigated using a self-developed high-speed rubbing tester, focusing on the effect of working parameters (linear velocity and incursion rate) on blade and coating damage mechanisms. A non-contact infrared thermometer and a high-speed camera were used to determine real-time changes in coating surface temperature and blade length. The wear morphology and elemental composition of the blade and coating were characterized by a scanning electron microscope, an ultra-depth three-dimensional microscope, and an energy spectrometer. The test results showed that at the same incursion rate, the degree of blade wear tended to increase and then decrease with the increase of linear velocity, and the maximum degree of blade wear was reached at 200 m/s. There was no significant correlation between the degree of blade wear and the incursion rate at the same linear velocity. The linear velocity was the primary influence on driving friction, while the incursion rate became a secondary factor, contrary to the well-known law in metal-based abradable coatings. The main forms of damage to blades included grooving, overheating, and micro-rupture. Plastic removal was the main wear mechanism for blades. The damage mechanism of ceramic-based abradable coatings was mainly characterized by sub-surface cracking. The brittle removal of the coating resulted in “stepped” wear of the blade and a short actual action time of the friction pair. In this paper, the wear mechanisms of nickel-based superalloy blades and ceramic-based abradable coatings were mapped for the first time.
Manufacture of Bamboo Spur Gear and the Dynamic Performance
Authors: Ochi shinji 
Published: September 2023

Abstract
This paper describes the manufacture of bamboo spur gears using bamboo powder and their dynamic performance. This research was compared the accuracy and dynamic performance of the bamboo gear and POM gear. At first, a disk-shaped preformed bamboo product was fabricated, then the product was manufactured into the gear using the gear hobbing machine. Next, the accuracy of the gear was measured, finally, generation noise, temperature of gear, and volume of wear were measured by using dynamic gear testing machine. As results, the accuracy of bamboo gear produced by method in this research was near to injection molded POM gear. The bamboo gear was showed that volume of wear is reduced by an increase in molding temperature. Moreover, the bamboo gear fabricated at 200 °C, under the condition of torque 0.5 Nm and 1.0Nm and number of revolutions from 500 rpm to 1500 rpm showed clearly that temperature, noise and wear have performance equivalent to POM gear as dynamic performance. However, the gear made from 100% bamboo powder could not withstand the load torque of 1.5Nm. It was considered that this is because the flexural strength of POM is 90MPa, while that of bamboo powder molding product is 60MPa. Therefore, when a bamboo gear using bamboo powder reinforced by bamboo fiber bundles was fabricated, it withstood up to 107 rotations even at a load torque of 1.5 Nm.
Western Blot analysis confirms nuclear localization of nodal ERα and PRB protein biomarkers in fractionated axillary node-positive breast cancer tissue: A Case Report
Authors: Ivanovic Vesna , Tepavcevic Snezana , Tanic Nasta Dedovic , Milovanovic Zorka , Stojiljkovic Bratislav , Vasiljevic Tijana , Mandusic Vesna 
Published: September 2023

Abstract
We present herein a Western blot (WB) approach as an extension to our recently developed and published method termed "Fractionation of Nodal Cell Suspension" (FNCS). The method enables an efficient subcellular fractionation into nuclear (N) and cytosolic (C) compartments of extremely fibrous and problematic metastatic Axillary Lymph Node (mALN) tissue. For the purpose of present experiments, a case of an invasive lobular breast cancer (BC) patient, with pT2N3aMx clinico-pathological characteristics and defined primary tumor markers (ERα 8, PRB 8, and HER2 score 0), was selected. Initially, mALN tissue of this patient was analyzed by immunohistochemistry (IHC) and a positive correlation of nodal ERα, PRB and HER2 biomarkers to those of primary tumor was obtained. Subsequently, the mALN was FNCS-fractionated into N and C and WB analysis demonstrateted a single N band for nodal ERα, PRB biomarkers and nuclear loading control (HDAC1), but not the C band, revealing negligible compartmental cross-contamination. At the same time, HER2 bands were not observed in either of compartments, reflecting lack of HER2 expression consistent with IHC status in both primary tumor and mALN tissue. In conclusion, our results confirm the nuclear expression of ERα, and PRB biomarkers in metastatic loci. Finally, our results clearly demonstrate the purity of the FNCS-generated compartments - the protocol that offers reliable tool for further analysis of nuclear versus cytosolic content in downstream analysis of potential biomarkers in mALN of BC patients.
An investigation of the phytochemical richness of fresh Musa paradisiaca L. (plantain) stem juice and its anticonvulsant potential on pentylenetetrazole (PTZ)-challenged rats
Authors: Ugwuoke Sabastine Chinweike , Nwanelo Valentine Odirachukwumma , Dawoye Yusufu , Ugwu Obiora Celestine , Osuji Dionysius Obinna , Ogugofor Martins Obinna , Okoro Ikechukwu Jacob , Odo Chigozie Paul , Nelson Treasure Nneka , Anosike Chioma Assumpta 
Published: September 2023

Abstract

This study was aimed at determining the therapeutic value of fresh Musa paradisiaca L. (MP) stem juice as a potential treatment for epileptic convulsions using a pentylenetetrazole (PTZ)-induced seizure model in rats. Six groups of albino rats (n = 4) were involved in the study. Group I was treated with normal saline (p.o), while group II was untreated and group III received diazepam (4 mg/kg, p.o). Group IV, V and VI received 50, 75 and 100% v/v oral dose of MP stem juice, respectively). The treatment lasted for 10 days, followed by PTZ (85 mg/kg b.w, i.p) administration 60 min later. Lethality test and phytochemical screening were conducted. The rats were closely watched and meticulously monitored for seizure manifestations/episodes with the aid of a stop watch. From the results, the MP stem juice up to 100% (v/v) was safe in mice and numerous bioactive compounds were found with phenols being the most abundant (9.46 ± 0.03 mg/g), followed by alkaloids (5.54 ± 0.98 mg/g) and flavonoids (4.27 ± 1.23 mg/g). For the seizure manifestation, three intermittent seizures (episodes 1, 2 and 3) were observed and the stem juice (75 and 100% v/v) significantly (p < 0.05) increased the latency periods of episode 1 tonic and clonic seizures. The stem juice at 50% (v/v) delayed the onset of episode 2 seizures for over 10 minutes more than the untreated group. The groups that received 75 and 100% (v/v) of the stem juice did not experience seizures during the episode 2 as seen in episode 1. The standard and the test groups did not experience seizure during the episode 3. The findings of this study have demonstrated that the fresh MP stem juice could prevent convulsions by increasing the latencies and decreasing relatively the durations of seizures in PTZ-challenged rats. This study, however, provides the pharmacological evidence for the folk claim behind the use of Musa paradisiaca stem juice to manage epileptic convulsions or seizure disorders.
Uncovering the Neuroanatomical Signature of the Transition from Normal Cognition to Mild Cognitive Impairment in Parkinson's Disease: A VBM and Brain Age Estimation Study
Authors: Beheshti Iman , Perron Jarrad , Ko Ji Hyun 
Published: September 2023

Abstract
The progression of Parkinson’s disease (PD) is often accompanied by cognitive decline. This study aims to uncover neuroanatomical indicators of the transition from healthful cognition to mild cognitive impairment (MCI) in PD using brain age estimation methodologies and structural neuroimaging data. Structural MRI data for 244 subjects from the Parkinson Progression Markers Initiative (PPMI) was acquired. 192 of these were PD patients with stable healthy cognitive function from baseline out to 5 years (PD-SHC), and as the remaining 52 were PD patients who had unstable healthy cognition and developed MCI within 5 years (PD-UHC). We conducted voxel-based morphometry (VBM), deformation-based morphometry, and cortical thickness analyses to measure structural brain differences between these groups at baseline and to assess any differences in brain aging. The VBM analysis revealed that PD-SHC patients have larger grey matter volumes compared to PD-UHC subjects at baseline. This difference was located entirely within the cerebellum with significant clusters found within the posterior and anterior lobes and on the declive and culmen regions of the vermis. No differences were observed in the white matter, local brain tissue volumetry or cortical thickness measurements between the two groups. At baseline, PD-UHC patients exhibited significantly greater brain aging than PD-SHC patients (mean difference = 3.24 years, Cohen’s d = 0.43; t(242) = 2.78, p = 0.005). Our analysis provides an in-depth understanding of the neuroanatomical signatures of cognitive decline in PD by demonstrating the role of the cerebellum as a site of early anatomical change that accompanies the transition from healthy cognition to MCI. This could aid in elucidating further changes along the structural-functional continuum which accompany this cognitive transition, serve as a biomarker of the earliest form of cognitive decline in patients with PD and enrich trials of cognitive intervention in this patient population.
Visible light-induced catalytic performance of composite photocatalyst synthesized with nanomaterials WO3 and two-dimensional ultrathin g-C3N4
Authors: Li Dongmei , Zhang Wenxin , Huang Yi , Feng Haoxuan , Wang Zilin , Yang Zhuohong , Chen Jingkai , Zhang Xueqiang , Zhang Gangyi , Chen Yanbing 
Published: September 2023

Abstract

To improve the visible light-induced catalytic activities of Ultrathin g-C3N4 (UCN), a promising photocatalyst WO3/UCN (WU) was synthesized. Its visible light-driven photocatalysis performance was controllable by adjusting the theoretical mass ratio of WO3/UCN. We have calibrated the optimal preparation conditions to be: WO3/UCN ratio as 1:1, the stirring time of the UCN and sodium tungstate mixture as 9 h and the volume of concentrated hydrochloric acid as 6 mL which was poured into the mixture solution with an extra stirring time of 1.5 h. The optimal photocatalyst WUopt had porous and wrinkled configurations. Its light absorption edge was 524 nm while that of UCN was 465 nm. The band gap of WUopt was 2.13 eV, 0.3 eV less than that of UCN. Therefore, the recombination rate of photo-generated electron–hole pairs of WUopt reduced significantly. The removal rate of WUopt on RhB was 97.3%. By contrast, the removal rate of UCN was much lower (53.4%). WUopt retained a high RhB removal rate, it was 5.5% lower than the initial one after being reused for five cycles. The photodegradation mechanism was facilitated through the strong oxidation behaviors from the active free radicals ·O2-, ·OH and h+ generated by WUopt under the visible light irradiation.
Inovasi pembelajaran pendidikan jasmani dengan modifikasi permainan bola besar bagi anak tunanetra
Authors: Azizah Alfiah Rizqi , Sukoco Pamuji 
Published: September 2023

Penelitian bertujuan menghasilkan model pembelajaran penjas untuk mengembangkan kemampuan directional awareness, auditory awareness, dan gerak dasar manipulatif anak tunanetra. Penelitian pengembangan mengikuti model Borg Gall (Sukmadinata) melalui 9 langkah. Uji coba skala kecil dilakukan di SLB N 1 Bantul sebanyak enam orang, skala besar dilakukan di SLB N 1 Kulonprogo dan SLB Hellen Keller yang berjumlah 10 orang. Hasil penelitian berupa model pembelajaran penjas permainan bola besar yang didokumentasikan dalam CD dan buku petunjuk pelaksanaan pembelajaran pada anak tunanetra. Model pembelajaran bola besar, terdapat lima permainan: (1) permainan bolingling, (2) bola jaring, (3) tangkap ceria, (4) rintangan hore dan (5) bola gawang ajaib. Pada akhir penelitian disimpulkan bahwa model pembelajaran yang dibuat sangat menarik, sesuai dengan karakteristik peserta didik, dapat digunakan sebagai cara mengajar penjas, serta sangat efektif untuk mengembangkan kemampuan directional awareness, auditory awareness, dan gerak dasar manipulatif Physical Education learning innovation with modified big ball games for blind children Abstract: This study aims to develop a teaching model of physical education for blind children in order to develop an ability in directional awareness, auditory awareness, and manipulative basic motion. This is research and development referred to Borg Gall in Sukmadinata through 9 steps. The small-scale trials were conducted on six students of SLB N 1 Bantul, while the large-scale trials were conducted on ten students of SLB N 1 Kulonprogro and SLB Hellen Keller Indonesia Yogyakarta. The result of this research is a model of physical education teaching large ball games that is documented in a CD and a guidebook of the implementation of learning for children with visual impairment. In the teaching model of large ball, there are five games, namely: (1) game of bolingling, (2) game of bola jaring, (3) game of tangkap ceria, (4) games of rintangan hore, and (5) game of bola gawang ajaib. The study concludes that the teaching model is very attractive. It is according to the characteristics of learners, it can be used as a way of teaching physical education, and it is very effective to develop the ability in directional awareness, auditory awareness, and manipulative basic motion in blind children.
Health Care Providers’ Readiness to Adopt an Interactive 3D Web App in Consultations About Female Genital Mutilation/Cutting: Qualitative Evaluation of a Prototype
Authors: Holuszko Olivia May , Abdulcadir Jasmine , Abbott Daisy , Clancy Jennifer 
Published: September 2023

Background
Comprehensive and appropriate health care provision to women and girls with female genital mutilation or cutting (FGM/C) is lacking. Use of visuals in health care provider (HCP) consultations facilitates the communication of health information and its comprehension by patients. A web app featuring a 3D visualization of the genitourinary anatomy was developed to support HCPs in conferring clinical information about FGM/C to patients.

Objective
The aim of this study was to explore HCP perspectives on the use of visuals in discussion about FGM/C with their patients as well as to obtain their feedback on whether an interactive 3D web app showing the genitourinary anatomy would be helpful in patient consultations about FGM/C, identifying key features that are relevant to their clinical practice.

Methods
We evaluated the web app through a semistructured interview protocol with seven HCPs from various disciplines experienced in care for women and girls with FGM/C in migration-destination settings. Interviews were audio- and video-recorded for transcription, and were then analyzed thematically for contextualized data regarding HCPs’ willingness to use a 3D web app visualizing anatomy in FGM/C consultations with patients.

Results
All but one of the seven participants expressed keen interest in using this web app and its 3D visuals of anatomy in FGM/C consultations with patients. Participants shared the common contexts for the use of visuals in health care for FGM/C and the concepts they are used to support, such as to help describe a patient’s genitals after FGM/C and reinforce an understanding of clitoral anatomy, to illustrate the process of defibulation, or to explain the physiological effects of FGM/C. Participants also highlighted the benefit of using visuals that patients can relate to, expressing approval for the ability to customize the vulva by FGM/C subtype, skin tone, and complexity of the visual shown in the web app. Despite critiques that the visualization may serve to perpetuate idealistic standards for how a vulva should look, participants largely agreed on the web app’s perceived usefulness to clinical practice and beyond.

Conclusions
Evaluation of the web app developed in this study identified that digital tools with 3D models of the genitourinary anatomy that are accessible, informative, and customizable to any specific patient are likely to aid HCPs in communicating clinical information about FGM/C in consultations. Universal access to the web app may be particularly useful for HCPs with less experience in FGM/C. The app also prompts options for applications such as for personal use, in medical education, in patient medical records, or in legal settings. Further qualitative research with patients is required to confirm that adoption of the web app by HCPs in a consultation setting will indeed benefit patient care for women and girls with FGM/C.