bluuebunny/crossref_metadata_2025_split huggingface dataset:
Size at first maturity on the mussel Mytilus platensis d'Orbigny, 1842 at the Southwest Atlantic
Authors: Yuvero M.C. , Torroglosa M.E. , Lomovasky B.J. , Giménez J. 
Published: November 2023

The size at first maturity of the bivalve Mytilus platensis d'Orbigny, 1842 was estimated in the intertidal population of Villa Gesell (37°15′S; 56°57′W), Buenos Aires, Argentina. We hypothesize a variation in population maturity associated with shell length (SL) and differences between females and males. Individuals were analyzed histologically, sexed (females and males), and classified as mature and immature. We carried out a kernel density estimation to allow us to visualize the distribution of the classifications based on the SL and used a generalized linear model to study the size at first sexual maturity for the population and between sexes. Our results showed immature specimens with reduced development in acini and expanded connective tissue. Mature males and females showed the acini expanded and filled with vitellogenic oocytes and spermatozoa, respectively. The size at first sexual maturity at which 50% of the population was mature (SL50) was 11.80 mm SL for all population, while SL50 was 11.42 mm in females and 10.83 mm in males. We determined significant interaction between SL and sex ( P < 0.05). We conclude that the knowledge of the reproductive aspects in intertidal populations is essential for the development of a potential fishing resource.
GREEN FINANCE: PAST, PRESENT AND FUTURE STUDIES
Authors: PALMACCIO MATTEO , GALEONE GRAZIANA , SHINI MATILDA , CAMPOBASSO FRANCESCO 
Published: November 2023

The research consists of a systematic literature review (SLR) emphasizing scholars’ views on the topic of green finance. Seeking to provide a deep understanding of the state of the art, the paper aims to draft implications and insights to address future research. Studies on green finance are investigated using the Scopus database as a source to get access to the dataset. The methodological approach is inspired by Kraus et al. (2020) in order “to identify, choose and critically appraise relevant pieces of research, and to generate collective insights of knowledge from past research” (Loureiro et al. 2019).
ENSO Disrupts Boreal Winter CRE Feedback
Authors: Jin Daeho , Kramer Ryan J. , Oreopoulos Lazaros , Lee Dongmin 
Published: November 2023

Abstract
Twenty years of satellite-based cloud and radiation observations allow us to examine the observed cloud radiative effect (CRE) feedback (i.e., CRE change per unit change in global mean surface temperature). By employing a decomposition method to separate the contribution of “internal changes” and “relative-frequency-of-occurrence (RFO) changes” of distinct cloud regime (CR) groups, notable seasonal contrasts of CRE feedback characteristics emerge. Boreal winter CRE feedback is dominated by the positive shortwave CRE (SWCRE) feedback of oceanic low-thick clouds, due to their decreasing RFO as temperature rises. This signal is most likely due to El Niño–Southern Oscillation (ENSO) activity. When ENSO signals are excluded, boreal winter CRE feedback becomes qualitatively similar to the boreal summer feedback, where several CR groups contribute to the total CRE feedback more evenly. Most CR groups’ CRE feedbacks largely come from changing RFO (e.g., the predominant transition from oceanic cumulus to broken clouds and more occurrences of higher convective clouds with warming temperature). At the same time, low-thick and broken clouds experience optical thinning and decreasing cloud fraction, and these features are more prominent in boreal summer than winter. Overall, the seasonally asymmetric patterns of CRE feedback, primarily due to ENSO, introduce complexity in assessments of CRE feedback.
The Impact of Charge-Neutral Atmospheric Propagation Path on the Altimetry Performance of Interferometric Radar Altimeter
Authors: Su Fanwei , Wang Yunhua , Bai Yining , Sun Daozhong , Chen Ge , Ma Chunyong , Zhang Yanmin , Jiang Wenzheng 
Published: November 2023

Abstract
The interferometric radar altimeter (IRA) is an innovative remote sensing sensor that enables the observation of mesoscale and submesoscale (meso–submesoscale) ocean dynamic phenomena. The charge-neutral atmosphere introduces path delay and bending in signal propagation. In this study, three types of sea surface height (SSH) errors caused by charge-neutral atmosphere propagation path for IRA were identified: differential delay error (DDE), path delay error (PDE), and path bending error (PBE). Among them, DDE exhibits a proportionality to the negative zenith neutral delay (ZND) and demonstrates a significant increase with the incident angle; PDE is solely reliant on the ZND; PBE is like DDE in trend and magnitude resembling a ramp. Intriguingly, PBE exhibits insensitivity to variations in the charge-neutral atmosphere, behaving more like a systematic error. Theoretically, PBE leads to an increase in the SSH error of about 1.2 cm at far range for SWOT. The ZND spectrum fitted from the Jason-3 zenith delay correction data is additionally utilized to simulate the spatial distribution of ZND anomaly within the SWOT observation swaths. Then, the impact of PDE anomaly (PDEA), PBE, and DDE anomaly (DDEA) on the observation performance of SWOT is also considered in conjunction with SSH data provided by HYCOM. The findings indicate that both PDEA and PBE significantly reduce IRA’s performance in oceanic phenomena, while the impact of DDEA can be disregarded. The PBE can distort the sea surface trend and increases the mean sea level within the range, requiring further attention.

Significance Statement
This paper focuses on how the signal path affects the accuracy of measuring sea surface height (SSH) using the interferometric radar altimeter (IRA) in the charge-neutral atmosphere. The present paper defines three types of SSH errors caused by propagation path to IRA, namely, differential delay error (DDE), path delay error (PDE), and path bending error (PBE). Three types of SSH errors will make a significant impact on the altimetry performance of IRA. Among them, PDE spatial anomaly and PBE will reduce the expected observation performance of the meso–submesoscale ocean phenomena in IRA’s swath, while PBE has not received enough attention in previous studies. Therefore, the research will provide a theoretical basis for IRA to correct the above SSH errors.
Phenotype and function of smooth muscle cells derived from the human normal great saphenous vein in response to hypoxia
Authors: Chu Haibo , Qin Yanyan , Qiu Tianzhen , Zhou Shunchang , Na Zhang , Sun Yanping , Xu Yongbo , Zhong Yuxu 
Published: November 2023

Objective The contribution of hypoxia to the pathophysiology of vascular smooth muscle cells (VSMCs) has not yet been fully elucidated. This study evaluated the effect of hypoxia on the phenotype and function of SMCs derived from the human normal great saphenous veins (NGSVs). Methods Fifteen NGSV tissue samples were collected. SMCs were isolated and cultured. Proliferation, migration, adhesion, senescence, and the structure of cytoskeletal filaments in SMCs were observed. mRNA and protein expression of Bax, Bcl-2, caspase-3, matrix metalloproteinases (MMP)-2, MMP-9, tissue inhibitor of metalloproteinases (TIMP)-1, and TIMP-2 was detected by fluorescent quantitative polymerase chain reaction and immunoblotting in the cobalt chloride (CoCl2) and the control groups. Results A decrease in the number of cytoskeletal filaments was observed. mRNA and protein expression of Bas and caspase-3 was significantly decreased, while the quantity of proliferation, migration, adhesion, senescence, and mRNA and protein expression of Bcl-2, MMP-2, MMP-9, TIMP-1, and TIMP-2 in SMCs in the CoCl2 group were significantly increased compared with the control group. Conclusion Under hypoxic conditions, the phenotype and function of SMCs derived from the human NGSVs were dysregulated, suggesting that VSMCs switch from the contractile phenotype to the secretory or synthetic phenotype, and more dedifferentiate, resulting in extracellular matrix deposition and apoptotic decrease through the intrinsic pathway.
Behavioral response for condom use messages to prevent human immunodeficiency virus/acquired immune deficiency syndrome among Bahir Dar City High School students, North West Ethiopia, 2022: Application of the extended parallel process model
Authors: Lakew Gebeyehu , Anagaw Tadele Fentabil , Talie Fenta Eneyew , Bogale Eyob Ketema 
Published: November 2023

Objective: The human immunodeficiency virus has become one of the world’s most serious health and development challenges. Human immunodeficiency virus prevention has not received sufficient attention, and the prevalence of human behavioral virus infections among Ethiopian high school and preparatory students has also increased. The aim of this study was to assess behavioral responses to condom use messages to prevent human immune virus/acquired immune deficiency syndrome among Bahir Dar city high school and preparatory students using the extended parallel process model, Bahir Dar, Ethiopia, 2022. Methodology: This institution-based cross-sectional study was conducted from 15 November to 15 December 2022, in Bahir Dar city. The data were collected from 601 participants. A multi-stage sampling technique was used to select the study participants. Data were entered into Epi-Info version 7.2.5 and exported to SPSS version 26 for analysis. Descriptive statistics, percentages, and frequencies were calculated. Bivariable logistic regression was performed to identify variables candidates for multivariable logistic regression at p-values less than 0.25, and multivariable logistic regression was performed to identify factors associated with the outcome variable at p-values < 0.05. A 95% confidence interval and odds ratio were used for the interpretation of the association. Result: The response rate of the respondents was 94.9%. The behavioral response for condom use messages was affected by grade level adjusted odds ratio, 0.473, 95% CI (0.252–0.886), knowledge adjusted odds ratio, 2.627, 95% CI (1.788–3.859), attitude adjusted odds ratio, 3.19, 95% CI (2.145–4.744), efficacy adjusted odds ratio, 3.286, 95% CI (2.03–5.339), and threat adjusted odds ratio, 0.249, 95% CI (0.167–0.369). The behavioral response for condom use messages was associated with danger control. Conclusion: The danger control response is 60.9%. Grade level, knowledge, attitude, and perceived and threat efficacies were independent predictors of danger control. Therefore, messages must aim to enhance threat component perception with appropriate efficacy to control danger and developed using scientific health communication strategies to promote behavioral change.
DLBCL: who is high risk and how should treatment be optimized?
Authors: Dabrowska-Iwanicka Anna , Nowakowski Grzegorz S. 
Published: November 2023

Abstract
Diffuse large B-cell lymphoma (DLBCL), not otherwise specified, is the most common subtype of large B-cell lymphoma, with differences in prognosis reflecting heterogeneity in the pathological, molecular, and clinical features. Current treatment standard is based on multiagent chemotherapy, including anthracycline and monoclonal anti-CD20 antibody, which leads to cure in 60% of patients. Recent years have brought new insights into lymphoma biology and have helped refine the risk groups. The results of these studies inspired the design of new clinical trials with targeted therapies and response-adapted strategies and allowed to identify groups of patients potentially benefiting from new agents. This review summarizes recent progress in identifying high-risk patients with DLBCL using clinical and biological prognostic factors assessed at diagnosis and during treatment in the front-line setting, as well as new treatment strategies with the application of targeted agents and immunotherapy, including response-adapted strategies.
GPIbα–filamin A interaction regulates megakaryocyte localization and budding during platelet biogenesis
Authors: Ellis Marc L. , Terreaux Antoine , Alwis Imala , Smythe Rhyll , Perdomo Jose , Eckly Anita , Cranmer Susan L. , Passam Freda H. , Maclean Jessica , Schoenwaelder Simone M. , Ruggeri Zaverio M. , Lanza Francois , Taoudi Samir , Yuan Yuping , Jackson Shaun P. 
Published: November 2023

Abstract
Glycoprotein Ibα (GPIbα) is expressed on the surface of platelets and megakaryocytes (MKs) and anchored to the membrane skeleton by filamin A (flnA). Although GPIb and flnA have fundamental roles in platelet biogenesis, the nature of this interaction in megakaryocyte biology remains ill-defined. We generated a mouse model expressing either human wild-type (WT) GPIbα (hGPIbαWT) or a flnA-binding mutant (hGPIbαFW) and lacking endogenous mouse GPIbα. Mice expressing the mutant GPIbα transgene exhibited macrothrombocytopenia with preserved GPIb surface expression. Platelet clearance was normal and differentiation of MKs to proplatelets was unimpaired in hGPIbαFW mice. The most striking abnormalities in hGPIbαFW MKs were the defective formation of the demarcation membrane system (DMS) and the redistribution of flnA from the cytoplasm to the peripheral margin of MKs. These abnormalities led to disorganized internal MK membranes and the generation of enlarged megakaryocyte membrane buds. The defective flnA-GPIbα interaction also resulted in misdirected release of buds away from the vasculature into bone marrow interstitium. Restoring the linkage between flnA and GPIbα corrected the flnA redistribution within MKs and DMS ultrastructural defects as well as restored normal bud size and release into sinusoids. These studies define a new mechanism of macrothrombocytopenia resulting from dysregulated MK budding. The link between flnA and GPIbα is not essential for the MK budding process, however, it plays a major role in regulating the structure of the DMS, bud morphogenesis, and the localized release of buds into the circulation.
The prognostic value of the NECPAL instrument, Palliative Prognostic Index, and PROFUND index in elderly residents of nursing homes with advanced chronic condition
Authors: Esteban-Burgos Ana Alejandra , Hueso-Montoro César , Mota-Romero Emilio , Montoya-Juarez Rafael , Gomez-Batiste Xavier , Garcia-Caro María Paz 
Published: November 2023

Abstract
Background
It is essential to assess the need for palliative care and the life prognosis of elderly nursing home residents with an advanced chronic condition, and the NECPAL ICO-CCOMS©4.0 prognostic instrument may be adequate for both purposes. The objective of this study was to examine the predictive capacity of NECPAL, the Palliative Prognosis Index, and the PROFUND index in elderly residents with advanced chronic condition with and without dementia, comparing their results at different time points.

Methods
This prospective observational study was undertaken in eight nursing homes, following the survival of 146 residents with advanced chronic condition (46.6% with dementia) at 3, 6, 12, and 24 months. The capacity of the three instruments to predict mortality was evaluated by calculating the area under the receiver operating characteristic curve (AUC), with 95% confidence interval, for the global population and separately for residents with and without dementia.

Results
The mean age of residents was 84.63 years (± 8.989 yrs); 67.8% were female. The highest predictive capacity was found for PROFUND at 3 months (95%CI: 0.526–0.756; p = 0.016), for PROFUND and NECPAL at 12 months (non-significant; AUC > 0.5), and NECPAL at 24 months (close-to-significant (AUC = 0.624; 95% CI: 0.499–0.750; p = 0.053). The highest capacity at 12 months was obtained using PROFUND in residents with dementia (AUC = 0.698; 95%CI: 0.566–0.829; p = 0.003) and NECPAL in residents without dementia (non-significant; AUC = 0.649; 95%CI: 0.432–0.867; p = 0.178). Significant differences in AUC values were observed between PROFUND at 12 (p = 0.017) and 24 (p = 0.028) months.

Conclusions
PROFUND offers the most accurate prediction of survival in elderly care home residents with advanced chronic condition overall and in those with dementia, especially over the short term, whereas NECPAL ICO-CCOMS©4.0 appears to be the most useful to predict the long-term survival of residents without dementia. These results support early evaluation of the need for palliative care in elderly care home residents with advanced chronic condition.
Clinical relevance of circulating ESR1 mutations during endocrine therapy for advanced hormone-dependent endometrial carcinoma
Authors: Drouyer Aurélien , Beaussire Ludivine , Jorda Pauline , Leheurteur Marianne , Guillemet Cécile , Berghian Anca , Georgescu Dragos , Di Fiore Frédéric , Perdrix Anne , Clatot Florian 
Published: November 2023

Abstract
Objective
Endocrine therapy is frequently administered in patients with hormone dependent (HR+) metastatic endometrial cancer. ESR1 mutations have emerged as a key mechanism of aromatase inhibitor (AI) resistance in HR + metastatic breast cancer and can be monitored using circulating tumor DNA (ctDNA). The aim of this study was to explore the incidence and clinical relevance of circulating ESR1 mutations in patients treated by AI or megestrol acetate (M) for advanced endometrial carcinoma.

Methodology
This single-center retrospective study was performed at the Henri Becquerel Center (Rouen) and looked for circulating ESR1 gene mutations by droplet digital PCR (E380Q, L536R, Y537S, Y537N, Y537C, D538G, S463P) in patients with advanced HR + endometrial carcinoma treated between 2008 and 2020 for at least 30 days by AI or M. Analyses were performed before exposure and at progression/during endocrine therapy.

Results
Twenty-two patients were included: 13 were treated with AI, 12 of whom progressed; 9 patients were treated with M, 8 of whom progressed. 68.1% of the patients had low-grade endometrial carcinoma and 54.5% had received chemotherapy in the metastatic setting. The median duration of treatment was 152 days (min 47 – max 629) with AI and 155 days (min 91-max 1297) with M. Under AI, there was no ESR1 mutation at baseline, and one Y537C mutation at progression with a variant allele frequency (VAF) of 0.14%. Under M, one patient had a Y537C (VAF 0.2%) at baseline that disappeared during treatment. Another patient had a Y537S mutation emergence at progression after 91 days of treatment (VAF 1.83%). There was no significant difference between the circulating DNA concentration before and after hormone therapy (p = 0.16).

Conclusion
ESR1 mutations do not seem to be involved in the mechanisms of resistance to AI or M in HR+ endometrial cancer. The clinical relevance of their detection is not demonstrated.
Misdiagnosis of scrotal and retroperitoneal lymphangioma in children
Authors: Wu Wei , Mo Jiayu , Tan Kezhe , Chen Xingzhao , Xu WeiJue , Liu JiangBin , Lv Zhibao 
Published: November 2023

Abstract
Background
Scrotal and retroperitoneal lymphangioma (SRL) in children is relatively rare and its clinical symptoms are usually difficult to distinguish from other conditions such as hydrocele and incarcerated inguinal oblique hernia. This study aimed to explore the clinical diagnosis and treatment of abdominal scrotal lymphangioma in children, and thus, to increase our understandings of this disease in clinical practice.

Method
This study enrolled nine boys, aged 1–10, who were admitted to Shanghai Children’s Hospital from January 2019 to December 2020 and who were finally confirmed with lymphangioma in the inguinal area. The clinical manifestations, diagnosis, and treatment of these children were analyzed retrospectively. The length of diagnostic process ranged from 3 weeks to 20 months. We also reviewed other cases of initially misdiagnosed cases of SRL in English publications from 2000 to 2022.

Results
The nine cases were misdiagnosed as hydrocele, hematoma, or inguinal hernia. Three patients received intracystic injection of bleomycin, three underwent laparoscopic mass resection, and three underwent resection of the inguinal lymphangioma under direct vision. Postoperative pathological analysis of the surgical specimens confirmed the diagnosis of benign cystic lesions and lymphangioma. Meanwhile, among the 14 cases of SRL in literature review, eight were misdiagnosed. Six were initially diagnosed as hydrocele, one as inguinal oblique hernia, and one as testicular tumor, all of which underwent ultrasonography scans. All cases were confirmed as lymphangioma after pathological examination.

Conclusion
The non-specific clinical manifestations may contribute to the misdiagnosis of scrotal masses in children. A detailed and accurate medical history, careful physical examination, and imaging findings are important factors contributing to the preoperative differential diagnosis of scrotal lumps in children, but the final diagnosis is based on pathological examination.
Can we more precisely classify exposure to antenatal depression and anxiety in multivariable prediction models of pregnancy and birth outcomes: a population-based cohort study
Authors: Thiele Grace A. , Ryan Deirdre M. , Oberlander Tim F. , Hanley Gillian E. 
Published: November 2023

Abstract
Background
Depression and anxiety are highly prevalent within the perinatal period and have been associated with myriad adverse pregnancy and birth outcomes. In this study, we sought to investigate whether population-based data can be used to build complex, longitudinal mental health histories that improve our ability to predict adverse pregnancy and birth outcomes.

Methods
Using population-based, administrative datasets, we examined individual-level mental health services use of all birth parents who delivered a live infant in British Columbia, Canada between April 1, 2000, and December 31, 2013, and who were registered with the provincial Medical Services Plan for over 100 days per year from 10-years preconception to 1-year postpartum. We operationalized variables to proxy severity, persistence, and frequency of depression/anxiety from preconception through pregnancy, then constructed predictive regression models for postpartum depression/anxiety and preterm birth.

Results
Predictive modeling of postpartum depression/anxiety and preterm birth revealed better predictions and stronger performance with inclusion of a more detailed preconception mental health history. Incorporating dichotomous indicators for depression/anxiety across preconception markedly improved predictive power and model fit. Our detailed measures of mental health service use predicted postpartum depression/anxiety much better than preterm birth. Variables characterizing use of outpatient psychiatry care and outpatient visit frequency within the first five years preconception were most useful in predicting postpartum depression/anxiety and preterm birth, respectively.

Conclusion
We report a feasible method for developing and applying more nuanced definitions of depression/anxiety within population-based data. By accounting for differing profiles of mental health treatment, mental health history, and current mental health, we can better control for severity of underlying conditions and thus better understand more complex associations between antenatal mental health and adverse outcomes.