bluuebunny/crossref_metadata_2025_split huggingface dataset:
The expanded spectrum of human disease associated with GREB1L likely includes complex congenital heart disease
Authors: Zhao Emily , Bomback Miles , Khan Atlas , Krishna Murthy Sarath , Solowiejczyk David , Vora Neeta L. , Gilmore Kelly L. , Giordano Jessica L. , Wapner Ronald J. , Sanna‐Cherchi Simone , Lyford Alex , Jelin Angie C. , Gharavi Ali G. , Hays Thomas 
Published: January 2024

AbstractObjectiveGREB1L has been linked prenatally to Potter's sequence, as well as less severe anomalies of the kidney, uterus, inner ear, and heart. The full phenotypic spectrum is unknown. The purpose of this study was to characterize known and novel pre‐ and postnatal phenotypes associated with GREB1L.MethodsWe solicited cases from the Fetal Sequencing Consortium, screened a population‐based genomic database, and conducted a comprehensive literature search to identify disease cases associated with GREB1L. We present a detailed phenotypic spectrum and molecular changes.ResultsOne hundred twenty‐seven individuals with 51 unique pathogenic or likely pathogenic GREB1L variants were identified. 24 (47%) variants were associated with isolated kidney anomalies, 19 (37%) with anomalies of multiple systems, including one case of hypoplastic left heart syndrome, five (10%) with isolated sensorineural hearing loss, two (4%) with isolated uterine agenesis; and one (2%) with isolated tetralogy of Fallot.ConclusionGREB1L may cause complex congenital heart disease (CHD) in humans. Clinicians should consider GREB1L testing in the setting of CHD, and cardiac screening in the setting of GREB1L variants.
Photoinduced Toxicity Caused by Gold Nanozymes and Photodynamic Dye Encapsulated in Submicron Polymer Shell
Authors: Sergeev Igor S. , Maksimova Elizaveta A. , Moiseeva Ekaterina O. , Griaznova Olga Yu. , Perkov Sergei A. , Demina Polina A. , Zaytsev Valeriy D. , Koksharov Yury A. , Rider Maxim A. , Zavidovskiy Ilya A. , Rudakovskaya Polina G. , Romanov Roman I. , Khlebtsov Boris N. , Orlova Anna O. , Deyev Sergey M. , Gorin Dmitry A. 
Published: January 2024

AbstractThe development of nanozymes, artificial enzymes made from inorganic nanoparticles, is widely studied due to their affordability, durability, and strength. Gold nanoparticles (AuNPs) are employed to imitate peroxidase, glucose oxidase, lactate oxidase, superoxide dismutase, and catalase. The last one transforms intracellular hydrogen peroxide into molecular oxygen, whose deficiency is characteristic of the hypoxic tumor microenvironment. Thus, gold nanoparticles are thought to enhance the overall effectiveness of photodynamic therapy. However, the enzyme‐like activity of nanoparticles rapidly decreases in biological media, due to the aggregation and formation of the so‐called “protein corona”. In this study, polymeric submicrocapsules loaded with AuNPs and a photodynamic dye are fabricated via Layer‐by‐Layer (LbL) assembly. The enhancement of photodynamic treatment efficacy by in situ production of oxygen by the catalase‐like effect of AuNPs is investigated. Polymeric capsules are thoroughly characterized in terms of physicochemical and catalytic properties, and as a proof of concept, their therapeutic potential is evaluated in vitro. Furthermore, encapsulated AuNPs shows significantly lower aggregation both upon storage and during the reaction course. The results shows that the polymer capsules, containing AuNPs and photodynamic dye, show significantly higher light‐induced cytotoxicity in comparison to the individual photodynamic dye, suggesting a synergistic effect between the formation of molecular oxygen by catalase‐like gold nanozymes and photodynamic action.
The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload
Authors: Tykvartova Tereza , Miklovic Matus , Kotrc Martin , Skaroupkova Petra , Kazdova Ludmila , Trnovska Jaroslava , Skop Vojtech , Kolar Michal , Novotny Jiri , Melenovsky Vojtech 
Published: January 2024

AbstractWhile phosphodiesterase‐5 inhibition (PED5i) may prevent hypertrophy and failure in pressure‐overloaded heart in an experimental model, the impact of PDE5i on volume‐overload (VO)‐induced hypertrophy is unknown. It is also unclear whether the hypertrophied right ventricle (RV) and left ventricle (LV) differ in their responsiveness to long‐term PDE5i and if this therapy affects renal function. The goal of this study was to elucidate the effect of PDE5i treatment in VO due to aorto‐caval fistula (ACF) and to compare PDE5i treatment with standard heart failure (HF) therapy with angiotensin‐converting enzyme inhibitor (ACEi). ACF/sham procedure was performed on male HanSD rats aged 8 weeks. ACF animals were randomized for PDE5i sildenafil, ACEi trandolapril, or placebo treatments. After 20 weeks, RV and LV function (echocardiography, pressure‐volume analysis), myocardial gene expression, and renal function were studied. Separate rat cohorts served for survival analysis. ACF led to biventricular eccentric hypertrophy (LV: +68%, RV: +145%), increased stroke work (LV: 3.6‐fold, RV: 6.7‐fold), and reduced load‐independent systolic function (PRSW, LV: −54%, RV: −51%). Both ACF ventricles exhibited upregulation of the genes of myocardial stress and glucose metabolism. ACEi but not PDE5i attenuated pulmonary congestion, LV remodeling, albuminuria, and improved survival (median survival in ACF/ACEi was 41 weeks vs. 35 weeks in ACF/placebo, p = .02). PDE5i increased cyclic guanosine monophosphate levels in the lungs, but not in the RV, LV, or kidney. PDE5i did not improve survival rate and cardiac and renal function in ACF rats, in contrast to ACEi. VO‐induced HF is not responsive to PDE5i therapy.
Simulation‐based inference for reliability model selection and parameter calibration: An application to fatigue
Authors: Ben Abdessalem Anis 
Published: January 2024

AbstractSelecting a “useful” model among a set of competing candidate models is a common problem in many disciplines and particularly in engineering applications. For a modeller, the best model fulfills a certain purpose best (e.g., the ability to accurately predict new data, good interpolation, precise estimates of lower/upper percentiles, etc.), which is typically assessed by comparing model simulations to the observed data. Approximate Bayesian computation (ABC) which is a statistical learning technique is used in this work for reliability model selection and parameter calibration using small/moderate fatigue life data sets. This is always the case in material fatigue due to the high cost and low efficiency of fatigue tests which are bottleneck problem when designing components/structures with regard to fatigue. The ABC is a likelihood‐free based method which means that it needs only a generative model to simulate the data. The proposed method provides a formal rank of the competing reliability models by eliminating gradually the least likely models in a parsimonious manner. It is flexible since it offers the possibility to use different metrics to measure the discrepancy between simulated and observed data. The choice of the appropriate distance function depends essentially on the purpose of model selection. Through various examples, it has been demonstrated that the ABC method has a number of very attractive properties, which makes it especially useful in probabilistic risk assessment and reliability analysis.
Fluorescent 5H‐Pyrano[3,2‐c]chromenes: Synthesis, Photophysical Properties and Sensing of Nucleophilic Anions
Authors: Chernov Nikita M. , Panov Maxim S. , Domotskaya Mariya Yu. , Spiridonova Dar'ya V. , Chistyi Leonid S. , Shutov Roman V. , Nikolaev Dmitrii M. , Ryazantsev Mikhail N. , Yakovlev Igor P. 
Published: January 2024

AbstractWe report the development of a convenient organocatalytic method for the synthesis of 5H‐pyrano[3,2‐c]chromenes from chromone‐containing acrylates and ethyl cyanoacetate. The synthesis is characterized by simple conditions (ethanol, basic catalysis) and good yields (up to 90 %). The synthesized pyrano[3,2‐c]chromenes are a promising new class of fluorescent compounds. They have intense fluorescence in the yellow‐green region of the spectrum (495–554 nm) with high quantum yields (up to 72 %) and exhibit large Stokes shifts (3514–5856 cm−1). We have demonstrated the possible application of the obtained pyrano[3,2‐c]chromenes as selective “turn‐off” sensors for nucleophilic anions, such as cyanide, sulfide and sulfite.
Augmenting Neutrophil Extracellular Traps with Carbonized Polymer Dots: A Potential Treatment for Bacterial Sepsis
Authors: Lin Chin‐Jung , Hwang Tsong‐Long , Wang Robert Y. L. , Nain Amit , Shih Ren‐Hong , Chang Lung , Lin Han‐Jia , Harroun Scott G. , Chang Huan‐Tsung , Huang Chih‐Ching 
Published: January 2024

AbstractSepsis is a life‐threatening condition that can progress to septic shock as the body's extreme response to pathogenesis damages its own vital organs. Staphylococcus aureus (S. aureus) accounts for 50% of nosocomial infections, which are clinically treated with antibiotics. However, methicillin‐resistant strains (MRSA) have emerged and can withstand harsh antibiotic treatment. To address this problem, curcumin (CCM) is employed to prepare carbonized polymer dots (CPDs) through mild pyrolysis. Contrary to curcumin, the as‐formed CCM‐CPDs are highly biocompatible and soluble in aqueous solution. Most importantly, the CCM‐CPDs induce the release of neutrophil extracellular traps (NETs) from the neutrophils, which entrap and eliminate microbes. In an MRSA‐induced septic mouse model, it is observed that CCM‐CPDs efficiently suppress bacterial colonization. Moreover, the intrinsic antioxidative, anti‐inflammatory, and anticoagulation activities resulting from the preserved functional groups of the precursor molecule on the CCM‐CPDs prevent progression to severe sepsis. As a result, infected mice treated with CCM‐CPDs show a significant decrease in mortality even through oral administration. Histological staining indicates negligible organ damage in the MRSA‐infected mice treated with CCM‐CPDs. It is believed that the in vivo studies presented herein demonstrate that multifunctional therapeutic CPDs hold great potential against life‐threatening infectious diseases.
Recent Advances in the Modification and Improvement of Bioprosthetic Heart Valves
Authors: Tong Qi , Cai Jie , Wang Zhengjie , Sun Yiren , Liang Xuyue , Xu Qiyue , Mahamoud Oumar Abdel , Qian Yongjun , Qian Zhiyong 
Published: January 2024

AbstractValvular heart disease (VHD) has become a burden and a growing public health problem in humans, causing significant morbidity and mortality worldwide. An increasing number of patients with severe VHD need to undergo heart valve replacement surgery, and artificial heart valves are in high demand. However, allogeneic valves from donors are lacking and cannot meet clinical practice needs. A mechanical heart valve can activate the coagulation pathway after contact with blood after implantation in the cardiovascular system, leading to thrombosis. Therefore, bioprosthetic heart valves (BHVs) are still a promising way to solve this problem. However, there are still challenges in the use of BHVs. For example, their longevity is still unsatisfactory due to the defects, such as thrombosis, structural valve degeneration, calcification, insufficient re‐endothelialization, and the inflammatory response. Therefore, strategies and methods are needed to effectively improve the biocompatibility and longevity of BHVs. This review describes the recent research advances in BHVs and strategies to improve their biocompatibility and longevity.
Strain Effects in Ru‐Au Bimetallic Aerogels Boost Electrocatalytic Hydrogen Evolution
Authors: Wei Wei , Guo Fei , Wang Cui , Wang Lingwei , Sheng Zhizhi , Wu Xiaodong , Cai Bin , Eychmüller Alexander 
Published: January 2024

AbstractTo improve the sluggish kinetics of the hydrogen evolution reaction (HER), a key component in water‐splitting applications, there is an urgent desire to develop efficient, cost‐effective, and stable electrocatalysts. Strain engineering is proving an efficient strategy for increasing the catalytic activity of electrocatalysts. This work presents the development of Ru‐Au bimetallic aerogels by a simple one‐step in situ reduction‐gelation approach, which exhibits strain effects and electron transfer to create a remarkable HER activity and stability in an alkaline environment. The surface strain induced by the bimetallic segregated structure shifts the d‐band center downward, enhancing catalysis by balancing the processes of water dissociation, OH* adsorption, and H* adsorption. Specifically, the optimized catalyst shows low overpotentials of only 24.1 mV at a current density of 10 mA cm−2 in alkaline electrolytes, surpassing commercial Pt/C. This study can contribute to the understanding of strain engineering in bimetallic electrocatalysts for HER at the atomic scale.
Nature‐Inspired Wet Drug Delivery Platforms
Authors: Ma Yutian , Cao Jian , Li Shiyao , Wang Lili , Meng Yufei , Chen Yupeng 
Published: January 2024

AbstractNature has created various organisms with unique chemical components and multi‐scale structures (e.g., foot proteins, toe pads, suckers, setose gill lamellae) to achieve wet adhesion functions to adapt to their complex living environments. These organisms can provide inspirations for designing wet adhesives with mediated drug release behaviors in target locations of biological surfaces. They exhibit conformal and enhanced wet adhesion, addressing the bottleneck of weaker tissue interface adhesion in the presence of body fluids. Herein, it is focused on the research progress of different wet adhesion and bioinspired fabrications, including adhesive protein‐based adhesion and inspired adhesives (e.g., mussel adhesion); capillarity and Stefan adhesion and inspired adhesive surfaces (e.g., tree frog adhesion); suction‐based adhesion and inspired suckers (e.g., octopus' adhesion); interlocking and friction‐based adhesion and potential inspirations (e.g., mayfly larva and teleost adhesion). Other secreted protein‐induced wet adhesion is also reviewed and various suckers for other organisms and their inspirations. Notably, one representative application scenario of these bioinspired wet adhesives is highlighted, where they function as efficient drug delivery platforms on target tissues and/or organs with requirements of both controllable wet adhesion and optimized drug release. Finally, the challenges of these bioinspired wet drug delivery platforms in the future is presented.
Slip‐resistant connections subjected to freeze‐thaw cycles
Authors: Fuente‐García Alfonso , Serrano‐López Miguel Ángel , López‐Colina Carlos , López‐Gayarre Fernando 
Published: January 2024

AbstractThere are many examples of steel structures subjected to severe environmental conditions with bolted connections directly exposed to climatic agents such as steel bridges, mining transfer towers, wind towers etc. In this experimental research, non‐slip joints with M16 and M20 bolts have been studied. The specimens were subjected to fourteen 12 h freeze‐thaw cycles, with periodic immersion in water and temperature oscillation. Subsequently, the connections were subjected to a slip test under monotonic load. The results were compared with other equal joints not subjected to freeze‐thaw cycles and kept at room temperature for the same time. Some interesting conclusions are extracted from this piece of research. It was observed that freeze‐thaw cycles negatively affect the slip resistance of non‐slip joints with GB+ZE surfaces, even with a slight increase in clamping force. Samples with SR and GB surfaces increase in their slip resistance was observed.
Air pollution, public health expenditure, and physical health: Evidence from China
Authors: Jiang Wei , Li Wei , Chen Yunfei 
Published: January 2024

AbstractAir pollution is known to have adverse effects on physical health, but the influence of public health expenditure (PHE) on physical health has received less attention. This study utilizes 2 years of panel data from the China Family Panel Studies (CFPS) to investigate the effects of air pollution and PHE on physical health. The main findings reveal that, for each unit increase in SO2, there is a corresponding decrease of 0.006 in physical health. For each unit increase in PHE, there is a 0.838 increase in physical health. Heterogeneity analysis indicates that the impact of air pollution on public health varies among different groups. Notably, air pollution has more detrimental effects on women's health compared to men, and middle‐aged and elderly individuals are more vulnerable to air pollution. Additionally, urban residents are more susceptible to the adverse effects of air pollution compared to rural residents. Furthermore, PHE positively impacts women's health and significantly enhances the health of rural residents. People residing in western and central regions are more susceptible to air pollution than those in the eastern regions. This underscores the importance of tailoring environmental pollution reduction and PHE increase policies to address the unique needs of various groups and regions in order to promote overall improvements in residents' health.
Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration
Authors: Yu Chunxiao , Li Xueyu , Ma Jinmin , Liang Shuzhang , Zhao Yan , Li Qi , Zhang Ruilin 
Published: January 2024

AbstractZebrafish have a remarkable ability to regenerate injured hearts. Altered hemodynamic forces after larval ventricle ablation activate the endocardial Klf2a-Notch signaling cascade to direct zebrafish cardiac regeneration. However, how the heart perceives blood flow changes and initiates signaling pathways promoting regeneration is not fully understood. The present study demonstrated that the mechanosensitive channel Trpv4 sensed the altered hemodynamic forces in injured hearts and its expression was regulated by blood flow. In addition to mediating the endocardial Klf2a-Notch signal cascade around the atrioventricular canal (AVC), we discovered that Trpv4 regulated nitric oxide (NO) signaling in the bulbus arteriosus (BA). Further experiments indicated that Notch signaling primarily acted at the early stage of regeneration, and the major role of NO signaling was at the late stage and through TGF-β pathway. Overall, our findings revealed that mechanosensitive channels perceived the changes in hemodynamics after ventricle injury, and provide novel insights into the temporal and spatial coordination of multiple signaling pathways regulating heart regeneration.
Description of a new freshwater bacterium Aquirufa regiilacus sp. nov., classification of the genera Aquirufa, Arundinibacter, Sandaracinomonas, and Tellurirhabdus to the family Spirosomataceae, classification of the genus Chryseotalea to the family Fulvivirgaceae and Litoribacter to the family Cyclobacteriaceae, as well as classification of Litoribacter alkaliphilus as a later heterotypic synonym of Litoribacter ruber
Authors: Pitt Alexandra , Lienbacher Stefan , Schmidt Johanna , Neumann-Schaal Meina , Wolf Jacqueline , Hahn Martin W. 
Published: January 2024

AbstractStrains LEOWEIH-7CT and LEPPI-3A were isolated from the Leopoldskroner Weiher, a lake located in the city of Salzburg, Austria. 16S rRNA gene similarities and phylogenetic reconstructions with 16S rRNA gene sequences as well as based on genome sequences revealed that the new strains belong to the A. antheringensis branch of the genus Aquirufa. Calculated whole-genome average nucleotide identity (gANI) and digital DNA–DNA hybridization (dDDH) values with the closely related type strains showed that the two strains represent a single new species. The strains grew aerobically and chemoorganotrophically, and the cells were rod shaped, on average 0.8 µm long and 0.3 µm wide, red pigmented and motile by gliding. The genome size of both strains was 2.6 Mbp and the G+C value was 41.9%. The genomes comprised genes predicted for the complete light-harvesting rhodopsin system and various carotenoids. We proposed to establish the name Aquirufa regiilacus sp. nov. for strain LEOWEIH-7CT (=DSM 116390T = JCM 36347T) as the type strain. Strain LEPPI-3A (=DSM 116391 = JCM 36348) also belongs to this new species. The calculated genome-based phylogenetic tree revealed that Aquirufa and some other genera currently allocated in the family Cytophagaceae need a reclassification. Aquirufa, Arundinibacter, Sandaracinomonas, and Tellurirhabdus should be designated to the family Spirosomataceae, the genus Chryseotalea to the family Fulvivirgaceae, and the genus Litoribacter to the family Cyclobacteriaceae. Furthermore, based on calculated gANI and dDDH values, Litoribacter alkaliphilus should be reclassified as a later heterotypic synonym of Litoribacter ruber.
Hilbert–Schmidt Estimates for Fermionic 2-Body Operators
Authors: Christiansen Martin Ravn 
Published: January 2024

AbstractWe prove that the 2-body operator $$\gamma _{2}^{\Psi }$$

γ

2

Ψ

of a fermionic N-particle state $$\Psi $$
Ψ
obeys $$\Vert \gamma _{2}^{\Psi }\Vert _{\textrm{HS}}\le \sqrt{5}N$$

‖

γ

2

Ψ

‖

HS

≤

5

N

, which complements the bound of Yang (Rev Mod Phys 34:694, 1962) that $$\Vert \gamma _{2}^{\Psi }\Vert _{\textrm{op}}\le N$$

‖

γ

2

Ψ

‖

op

≤
N

. This estimate furthermore resolves a conjecture of Carlen–Lieb–Reuvers (Commun Math Phys 344:655–671, 2016) concerning the entropy of the normalized 2-body operator. We also prove that the Hilbert–Schmidt norm of the truncated 2-body operator $$\gamma _{2}^{\Psi ,T}$$

γ

2

Ψ
,
T

obeys the inequality $$\Vert \gamma _{2}^{\Psi ,T}\Vert _{\textrm{HS}}\le \sqrt{5N\,\textrm{tr}\,(\gamma _{1}^{\Psi }(1-\gamma _{1}^{\Psi }))}$$

‖

γ

2

Ψ
,
T

‖

HS

≤

5
N

tr

(

γ

1

Ψ

(
1
-

γ

1

Ψ

)

)

.
Estimating the impact of label design on reducing the risk of medication errors by applying HEART in drug administration
Authors: Aceves-Gonzalez Carlos , Caro-Rojas Angela , Rey-Galindo John A. , Aristizabal-Ruiz Luz , Hernández-Cruz Karen 
Published: January 2024

Abstract
Medication errors are one of the biggest problems in healthcare. The medicines’ poor labelling design (i.e. look-alike labels) is a well-recognised risk for potential confusion, wrong administration, and patient damage. Human factors and ergonomics (HFE) encourages the human-centred design of system elements, which might reduce medication errors and improve people’s well-being and system performance.

Objective
The aim of the present study is twofold: (i) to use a human reliability analysis technique to evaluate a medication administration task within a simulated scenario of a neonatal intensive care unit (NICU) and (ii) to estimate the impact of a human-centred design (HCD) label in medication administration compared to a look-alike (LA) label.

Method
This paper used a modified version of the human error assessment and reduction technique (HEART) to analyse a medication administration task in a simulated NICU scenario. The modified technique involved expert nurses quantifying the likelihood of unreliability of a task and rating the conditions, including medicine labels, which most affect the successful completion of the task.

Results
Findings suggest that error producing conditions (EPCs), such as a shortage of time available for error detection and correction, no independent checking of output, and distractions, might increase human error probability (HEP) in administering medications. Results also showed that the assessed HEP and the relative percentage of contribution to unreliability reduced by more than 40% when the HCD label was evaluated compared to the LA label.

Conclusion
Including labelling design based on HFE might help increase human reliability when administering medications under critical conditions.