bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing robotic thyroid surgery: lessons learned from an retrospective analysis of 104 cases
Authors: Wang Bo , Yu Jia-Fan , Ao Wei , Wang Jun , Guo Xin-Yi , Li Meng-Yao , Huang Wen-Yu , Zhou Chi-Peng , Yan Shou-Yi , Zhang Li-Yong , Wang Si-Si , Cai Shao-Jun , Lin Si-Ying , Zhao Wen-Xin 
Published: January 2024

BackgroundRobotic assistance in thyroidectomy is a developing field that promises enhanced surgical precision and improved patient outcomes. This study investigates the impact of the da Vinci Surgical System on operative efficiency, learning curve, and postoperative outcomes in thyroid surgery.MethodsWe conducted a retrospective cohort study of 104 patients who underwent robotic thyroidectomy between March 2018 and January 2022. We evaluated the learning curve using the Cumulative Sum (CUSUM) analysis and analyzed operative times, complication rates, and postoperative recovery metrics.ResultsThe cohort had a mean age of 36 years, predominantly female (68.3%). The average body mass index (BMI) was within the normal range. A significant reduction in operative times was observed as the series progressed, with no permanent hypoparathyroidism or recurrent laryngeal nerve injuries reported. The learning curve plateaued after the 37th case. Postoperative recovery was consistent, with no significant difference in hospital stay duration. Complications were minimal, with a noted decrease in transient vocal cord palsy as experience with the robotic system increased.ConclusionRobotic thyroidectomy using the da Vinci system has demonstrated a significant improvement in operative efficiency without compromising safety. The learning curve is steep but manageable, and once overcome, it leads to improved surgical outcomes and high patient satisfaction. Further research with larger datasets and longer follow-up is necessary to establish the long-term benefits of robotic thyroidectomy.
Efficacy of sotrovimab on omicron BA.2, BA.4 and BA.5 subvariants of sars-cov-2 vs. other early therapies: a systematic review and meta-analysis of literature data
Authors: Russo Antonio , Grimaldi Pierantonio , Pisaturo Mariantonietta , Onorato Lorenzo , Coppola Nicola 
Published: January 2024

BackgroundThe aim of this meta-analysis was to ascertain whether sotrovimab was effective in reducing COVID-19 related hospitalization and mortality also in Omicron BA.2, BA.4 and BA.5 subvariants compared to other antivirals effective in index period.MethodsA systematic review and meta-analysis of Randomized Controlled Trials (RCTs) and observational studies comparing the efficacy of early treatment with sotrovimab compared to other early treatment effective in index period, antivirals or monoclonal antibodies (mAbs), in patients with COVID-19 during BA.2, BA.4, BA.5 waves, conducted in accordance with PRISMA guidelines. We searched MEDLINE, Google Scholar and the Cochrane Library. Mortality and hospitalization were defined as outcomes.ResultsFour studies were included, allowing a meta-analysis of 8,041 patients. Meta-analysis showed no statistical difference between groups in hospitalization and mortality. Precisely, the RR of mortality showed no difference in the sotrovimab group compared to treatment with other drugs (OR 0.38, 95% CI 0.10-1.49, p&lt;0.166). As regards the rate of hospitalization, no significant difference resulted between the patients treated with sotrovimab and those with other drugs (OR 1.66, 95% CI 0.41-6.66, p=0.477).InterpretationIn conclusion, this meta-analysis showed no significant difference between sotrovimab or other antivirals in reducing COVID-19 evolution in patients with a high risk of progression, considering both hospitalization and mortality.
Psoriasis and biological drugs at the time of SARS-CoV-2 infection: a mini review outlining risk of infection, seroprevalence, and safety and efficacy of the BNT162b2 vaccine
Authors: Railton Janosch , Volonté Martina , Isoletta Eugenio , Bonelli Alice , Barruscotti Stefania , Brazzelli Valeria 
Published: January 2024

ObjectiveThe aim of this study is to review the life of patients with psoriasis on biologic therapy during the SARS-CoV-2 pandemic and the relevance of frailty within this context, reviewing studies that describe the course and severity of infection in patients with psoriasis on biologics, the seroprevalence of SARS-CoV-2, and the safety and efficacy of the BNT162b2 vaccine in these patients.Materials and methodsThe keywords “Psoriasis,” “Biologics,” “SARS-CoV-2,” “COVID-19,” and “BNT162b2 Vaccine” were used in various combinations on database engines to find relevant articles on this topic.ResultsA total of 36 articles were found, with 20 concerning the course, severity, and seroprevalence of SARS-CoV-2 in patients with psoriasis on biologic therapy and 16 concerning safety and efficacy of BNT162b2 in these patients.DiscussionPatients with psoriasis on biologic therapy did not have increased seroprevalence compared with the general population, indicating that they were not at an increased risk of SARS-CoV-2 infection compared with the general population. Furthermore, the immunosuppressive action of biologics may be protective, as patients on biologic therapy had better outcomes and less risk of severe infection. The seroconversion rate against SARS-CoV-2 from the BNT162b2 vaccine was similar in both patients with psoriasis on biologics and the general population, indicating that efficacy is not hindered by the biologic therapy. However, the cellular response in population with psoriasis was significantly less intense, and the humoral immune response was weaker than that in the general population, demonstrating that the possibility of tighter vaccination schedules and additional doses may be advantageous in these patients.
EEG generation mechanism of lower limb active movement intention and its virtual reality induction enhancement: a preliminary study
Authors: Dong Runlin , Zhang Xiaodong , Li Hanzhe , Masengo Gilbert , Zhu Aibin , Shi Xiaojun , He Chen 
Published: January 2024

IntroductionActive rehabilitation requires active neurological participation when users use rehabilitation equipment. A brain-computer interface (BCI) is a direct communication channel for detecting changes in the nervous system. Individuals with dyskinesia have unclear intentions to initiate movement due to physical or psychological factors, which is not conducive to detection. Virtual reality (VR) technology can be a potential tool to enhance the movement intention from pre-movement neural signals in clinical exercise therapy. However, its effect on electroencephalogram (EEG) signals is not yet known. Therefore, the objective of this paper is to construct a model of the EEG signal generation mechanism of lower limb active movement intention and then investigate whether VR induction could improve movement intention detection based on EEG.MethodsFirstly, a neural dynamic model of lower limb active movement intention generation was established from the perspective of signal transmission and information processing. Secondly, the movement-related EEG signal was calculated based on the model, and the effect of VR induction was simulated. Movement-related cortical potential (MRCP) and event-related desynchronization (ERD) features were extracted to analyze the enhancement of movement intention. Finally, we recorded EEG signals of 12 subjects in normal and VR environments to verify the effectiveness and feasibility of the above model and VR induction enhancement of lower limb active movement intention for individuals with dyskinesia.ResultsSimulation and experimental results show that VR induction can effectively enhance the EEG features of subjects and improve the detectability of movement intention.DiscussionThe proposed model can simulate the EEG signal of lower limb active movement intention, and VR induction can enhance the early and accurate detectability of lower limb active movement intention. It lays the foundation for further robot control based on the actual needs of users.
The influence of the merger process between two tertiary hospitals in Romania on job satisfaction among staff
Authors: Ilea Codrin Dan Nicolae , Daina Lucia Georgeta , Manole Felicia , Daina Mădalina Diana , Tirt Dorel Petru , Popa Anca 
Published: January 2024

AimThe purpose of this study is to evaluate the influence of the merger process of two tertiary hospitals located in the northwest of Romania on the professional satisfaction among medical and non-medical staff and to develop a standardized satisfaction questionnaire for romanian hospitals.Methods1750 questionnaires distributed within County Clinical Emergency Hospital Bihor (CCEHBh) ten months and one year and four months after the merger process were analyzed.ResultsThe percentage of staff who declare themselves satisfied with their work one year and four months after the merger is 80.14%. It has a downward trend compared to the result measured 10 months after the merger (86.14%) (χ2 test, p &lt; 0.01). The aspects that were rated with the lowest percentage as satisfactory were the possibility of promotion (41.89%) and job security (53.38%). A statistically significant decrease was also recorded in the assessment of career prospects (from 81.49% to 74.73%, χ2 test, p &lt; 0.0001).ConclusionsEven if there was a decrease in job satisfaction between the two evaluated periods, we can state that the general level at the last measurement is a good one (4.07 out of a maximum of 5). There was no significant difference in job satisfaction 1 year and 4 months after the merger for staff in the merged unit (4.06) compared to staff in the absorbing unit (4.09). The questionnaire applied in 2023 is one that has proven validity and reliability, being a good starting point for creating a standardized questionnaire that could be implemented in the vast majority of hospitals in Romania. The application of the questionnaire at an interval of 3–6 months would highlight the result of the implemented measures and the trend of employee satisfaction within CCEHBh.
Judgments of relevance in preschoolers: a study of training and transfer of self-cueing strategies
Authors: Leclercq Marion , Mombo Wilfried T. , Clerc Jérôme 
Published: January 2024

IntroductionWhen facing a task, children must analyze it precisely to fully identify what its goal is. This is particularly difficult for young children, who mainly rely on environmental cues to get there. Research suggests that training children to look for the most relevant perceptual cues is promising. Furthermore, as transferring skills to a new task is difficult, the question of whether young children are able to transfer such training remains open. The aim of this study was to test the extent to which two strategies of goal self-cueing—labeling and pointing—can help 4-year-old children to identify the relevant cues to clearly identify the goal of the task. The effects of explicit strategy training were tested in a near transfer task.MethodNinety-nine typically developing 4 year olds took part in the study. They were divided into three groups: two were trained collectively in one of the two strategies and the third group as a control group with no strategy training. All children performed a cued card-sorting task four times: Pre-test, Collective training, Post-test, and Transfer with new cards.ResultsResults confirmed the beneficial effect of strategy training on goal identification, particularly after training (Post-test). In the transfer phase, all three groups performed equally well.DiscussionThis study contributes to our understanding of how young children seek information when they look for the most relevant cues for identifying the goal of a task, and the benefits they may derive in a transfer task. It seems that the use of visual cues and self-cueing strategies helps preschoolers to clearly identify the goal of a task. Results are discussed in the light of the self-regulated learning framework. Some possible classroom applications are suggested.
A survey-based assessment of rates and covariates of mpox diagnosis and vaccination provides evidence to refine eligibility criteria for mpox vaccination among gay, bisexual and other men who have sex with men in the Netherlands
Authors: Adam Philippe C. G. , Op de Coul Eline L. M. , Zantkuijl Paul , Xiridou Maria , Bos Hanna , Blom Cor , Ketsuwan Itsada , te Wierik Margreet J. M. , David Silke , de Wit John B. F. 
Published: January 2024

BackgroundThe 2022 multicountry mpox outbreaks predominantly affected gay, bisexual and other men who have sex with men (GBMSM) in non-endemic countries, including in the Netherlands. We conducted a survey-based assessment of the alignment between the risk factors associated with mpox diagnosis among GBMSM in the Netherlands and the eligibility criteria used in 2022 for vaccinating this group, with the aim to refine these criteria.MethodsAn online self-report survey was conducted among adult GBMSM in the Netherlands between 29 July and 30 August 2022, corresponding to the first month of the Dutch mpox vaccination campaign. GBMSM were recruited via advertisements on social media and gay dating apps. Participants reported on their sexual behaviour, mpox diagnosis, and/or (initial) mpox vaccination since the start of the outbreak. Covariables of mpox diagnosis and vaccination were assessed using logistic regression analyses.ResultsOf the 2,460 participants, 73 (3.0%, 95% CI 2.3–3.6%) were diagnosed with mpox and 485 (19.7%, 95% CI 18.1–21.3%) had received (initial) mpox vaccination. Using sample weighting, we estimated that, of the GBMSM population aged 18–80 years in the Netherlands, 1.1% (95% CI 0.7–1.6%) had been diagnosed with mpox and 7.8% (95% CI 6.8–8.9%) had received (initial) vaccination. HIV-PrEP use, living with HIV, reporting ≥20 sex partners in the past 12 months, and sex in sex venues/parties in the past 2 months were independent risk factors for mpox diagnosis. Except for sex in sex venues/parties, these variables were also independently associated with mpox vaccination.ConclusionThis study provides novel evidence regarding the degree to which the 2022 eligibility criteria for mpox vaccination align with the risk factors for mpox among GBMSM in the Netherlands. The findings contribute to a refinement of the eligibility criteria for mpox vaccination, to which sex in sex venues/parties should be added.
Augmented reality for supporting the interaction between pedestrians and automated vehicles: an experimental outdoor study
Authors: Aleva Thomas K. , Tabone Wilbert , Dodou Dimitra , de Winter Joost C. F. 
Published: January 2024

Introduction: Communication from automated vehicles (AVs) to pedestrians using augmented reality (AR) could positively contribute to traffic safety. However, previous AR research for pedestrians was mainly conducted through online questionnaires or experiments in virtual environments instead of real ones.Methods: In this study, 28 participants conducted trials outdoors with an approaching AV and were supported by four different AR interfaces. The AR experience was created by having participants wear a Varjo XR-3 headset with see-through functionality, with the AV and AR elements virtually overlaid onto the real environment. The AR interfaces were vehicle-locked (Planes on vehicle), world-locked (Fixed pedestrian lights, Virtual fence), or head-locked (Pedestrian lights HUD). Participants had to hold down a button when they felt it was safe to cross, and their opinions were obtained through rating scales, interviews, and a questionnaire.Results: The results showed that participants had a subjective preference for AR interfaces over no AR interface. Furthermore, the Pedestrian lights HUD was more effective than no AR interface in a statistically significant manner, as it led to participants more frequently keeping the button pressed. The Fixed pedestrian lights scored lower than the other interfaces, presumably due to low saliency and the fact that participants had to visually identify both this AR interface and the AV.Discussion: In conclusion, while users favour AR in AV-pedestrian interactions over no AR, its effectiveness depends on design factors like location, visibility, and visual attention demands. In conclusion, this work provides important insights into the use of AR outdoors. The findings illustrate that, in these circumstances, a clear and easily interpretable AR interface is of key importance.
Microbiota–Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies
Authors: Raoul Pauline , Maccauro Valeria , Cintoni Marco , Scarpellini Emidio , Ianiro Gianluca , Gasbarrini Antonio , Mele Maria Cristina , Rinninella Emanuele 
Published: January 2024

Gastric cancer (GC) is one of the most common causes of cancer deaths, and GC treatments represent a large area of research. Although initially regarded as a sterile organ and unsuitable for microbial communities, the discovery of Helicobacter pylori made us realize that some microbes can colonize the stomach. In recent years, growing interest in gastric bacteria has expanded to the gut microbiota and, more recently, to the oral microbiota. Indeed, the oral–gastric–gut microbiota axis may play a crucial role in maintaining homeostasis, while changes in microbiota composition in GC patients can influence clinical outcomes. On the one hand, the microbiota and its metabolites may significantly influence the progression of GC, while anti-GC treatments such as gastrectomy and chemotherapy may significantly impact the oral–gastric–gut microbiota axis of GC patients. In this context, the role of nutritional therapies, including diet, prebiotics, and probiotics, in treating GC should not be underestimated. Wit this review, we aim to highlight the main role of the gastric, oral, and gut microbiota in GC onset and progression, representing potential future biomarkers for early GC detection and a target for efficient nutritional therapies during the course of GC.
Findings of an orthodontic and osteopathic diagnostic of individuals with an asymmetric narrowing of maxilla
Authors: Vasilyeva M. B. , Perevezentsev G. S. , Kosyreva T. F. 
Published: January 2024

Relevance. Postural disorders and their connection to dentofacial abnormalities represent a prominent subject in modern medicine, establishing a new diagnostic standard within the emerging fields of orthodontic and osteopathic diagnostic techniques.Objective. Establish a correlation between asymmetric narrowing of maxilla and postural disorders in children and teens aged 6 to 15 years. Substantiate the necessity for a combined approach involving both orthodontic and osteopathic diagnostics in this age group, aiming to develop a comprehensive treatment algorithm.Materials and methods. Orthodontists and an osteopathic physician conducted diagnostic procedures for 320 subjects. Verification methods included standardized questionnaires for orthodontics and osteopathy, digital photography, radiological analysis using cone beam computer tomography (CBCT) of the head, electromyography (EMG), and computer-aided optical postural topography with the DIERS formetric 4D motion system.Results. Among the 320 subjects examined, the study revealed that 65% presented with an asymmetric narrowing of maxilla. Digital photography illustrated deviations from the norm in the total width of the maxilla for all subjects, a critical factor influencing proper tongue posture, swallowing, and breathing patterns. Facial asymmetry and temporomandibular disorders (TMD) were prevalent among the majority of patients, with a reported mandibular deviation observed in 100% of cases. Based on CBCT data, the transverse dimension of the asymmetrically narrow maxilla, relative to the mid-sagittal axis, was found to be reduced, along with a concomitant displacement of the greater wings of the sphenoid bone. The measured electric activity of masticatory and temporal muscles supported the diagnosis of asymmetric muscular dysfunction. Additionally, irregularities in the sphenobasilar synchondrosis (SBS) were identified. Moreover, patients with asymmetric maxillary narrowing exhibited static and dynamic imbalance in the body, along with disorders of body posture and foot profile. These observations were made through visual assessment, manual testing, and the DIERS formetric 4D motion optical posture topography system.Conclusion. Asymmetric maxillary narrowing strongly correlated with posture disorders, static and dynamic imbalances in the body, and dysfunctions in primary activities such as chewing, swallowing, breathing, and gait patterns. To achieve a predictable outcome without complications, it is recommended to pursue both orthodontic and osteopathic treatments for cases involving an asymmetric narrowing of maxilla.
Développement, administration territoriale et participation de la population. L’exemple du Sénégal (1960 à 1977)
Authors: Cournot Claude 
Published: January 2024

Development, territorial administration and people’s participation — The Senegalese case (1966-1977). The Senegalese example is quite remarkable, yet it has no model value. Its remarkable nature results from the fact that for the last eighteen years the rules of the country have consistently looked for formulae and Systems which are meant both to bring innovation and to stay within the ambit of African traditions.
Maybe public administration's major defect is to cling to traditional structures and attitudes, however this is not the case with Senegal which gives also an example through its capacity to build up a System on the basis of collective effort within the framework of a liberal regime. But it has no model value, since a model has no value. Senegal has practically no problems of division or ethnic rivalry which upset so many African countries. It is precisely this feature which has made the achievement of decentralized structures possible without jeopardizing the country’s unity.
When looking at the future of Senegalese rural communities, one in fact is led to take them as the basis, both in a political and architectural sense of the term, for the whole of developmental policy ; they are, indeed, the prime factor of democratic and liberal construction, and yet they are also the closest to the socio-cultural tradition of Senegal and the "négritude" so dear to Léopold Senghor.
La coopération agricole en France
Authors: Hirschfeld André 
Published: January 2024

La cooperación agrícola en Francia

Después de recordar los principios del movimiento cooperativo y de définir el estatuto legal de las cooperativas agrícolas, estudia el autor, uno trás otro, el funcionamiento de una cooperativa agricola, la relación entre la coopérativa y el Estado y los requisitos para la creación de una cooperativa.
Después de indicar las razones del cambio en las motivaciones de adhesión de los agricultores a une cooperativa, tiene por esencial ahora el autor el desarrollo del espiritu cooperativo entre los adhérentes. Los objetivos del movimiento cooperador francés visan pués ante todo una revitalización del compromiso cooperador y una confirmaciôn del principio de solidaridad entre los ramos de la cooperaciôn y todas empresas cooperativas.
Autonomie et participation : bilan de la loi d’orientation
Authors: Vedel Georges 
Published: January 2024

Autonomía - Participación : resultados de la Ley de Orientación hasta ahora.
La Ley de Orientación de la enseñanza superior del 12 de noviembre de 1.968 constituye una solución política a un problema político : había, por una parte, de proporcionar la puesta en marcha de la Universidad y a este efecto de acordar cierto número de facilidades a las minoridades activas que, sin ello, arriesgaban de perpetuar el desorden ; por otra parte, había de lograr al nivel parlamentario la mayoría la más larga posible. Los resultados de esta reforma en el acto centrada sobre temas de primer plano, poniendo a un lado los problemas fundamentales, constan en este triple efecto : primero, no han solucionado los verdaderos problemas, segundo, los objetivos propuestos no han sido logrados y tercero, los efectos positivos producidos no han dejado de sorprender a todos los interesados.