bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in the prevalence of uveitis between Crohn's disease and ulcerative colitis: A systematic review and meta‐analysis
Authors: Lin Haowen , Zhang Jiaqing , Liang Chen , Wu Dongxuan , Tan Yuan , Luo Lixia , Liu Zhenzhen 
Published: October 2023

AbstractPurposeUveitis is one of the ocular manifestations of inflammatory bowel disease (IBD) that is often overlooked and has been considered a sign of severe IBD. As typical subtypes of IBD, differences exist in the prevalence of uveitis between Crohn's disease (CD) and ulcerative colitis (UC). Our study systematically assessed differences in the prevalence of uveitis between CD and UC.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines were used. We performed a systematic review of published literature from PubMed and Embase on 30 March 2022. Two investigators independently selected studies, extracted data and evaluated methodological quality. Either a fixed‐ or a random‐effects model was used to calculate the risk ratio (RR), odds ratio (OR) and 95% confidence interval (95% CI) depending on the heterogeneity of studies. Sensitivity analysis was used to examine the heterogeneity by removing article by article, while subgroup analysis was conducted in accordance with various regions.ResultsOur study included data from 14 studies encompassing 115 854 participants. The prevalence of uveitis in IBD was estimated to be 2.38% (95% CI 1.60%–3.17%). The prevalence of uveitis in CD (3.27%, 95% CI 2.15%–4.39%) was significantly higher than in UC (1.60%, 95% CI 0.93%–2.27%; RR 1.76, 95% CI 1.39–2.22, p < 0.05). In subgroup analysis, a higher incidence of CD combined with uveitis was also observed in IBD patients residing in Europe (RR 1.75, 95% CI 1.37–2.24).ConclusionsData from 115 854 IBD patients showed that CD patients were more likely to suffer from uveitis than UC patients. Ocular manifestations in IBD, particularly CD, warrant greater attention.
The use of microtracers in food‐effect trials: An alternative study design for toxic drugs with long half‐lives exemplified by the case for alectinib
Authors: van der Heijden L. T. , Steeghs N. , Beijnen J. H. , Huitema A. D. R. , Dorlo T. P. C. 
Published: October 2023

AbstractThe traditional design of food‐effect studies has a high patient burden for toxic drugs with long half‐lives (e.g., anticancer agents). Microtracers could be used to assess food‐effect in patients without influencing their ongoing treatment. The feasibility of a microtracer food‐effect study during steady‐state of the therapeutic drug was investigated in an in silico simulation study with alectinib as an example for a relative toxic drug with a long half‐life. Microtracer pharmacokinetics were simulated based on a previously published population pharmacokinetic model and used for estimation of a model with and a model without food as a covariate on oral bioavailability of alectinib (assuming a 40% food‐effect). Power was defined as the fraction of clinical trials where a significant (p < 0.01) food‐effect was identified. The proposed study design of 10 patients on steady‐state treatment, 10 blood samples collected within 24 h after administration and an assumed food‐effect of 40% had a power of 99.9%. The mean estimated food‐effect was 39.8% (80% confidence interval: 31.0%–48.6%). The feasibility of microtracer food‐effect studies was demonstrated. The design of the microtracer food‐effect study allowed estimation of the food‐effect with minimal influence on therapeutic treatment and reducing patient burden compared to the traditional study design for toxic drugs with long half‐lives.
Association between chronic kidney disease and risk of bullous pemphigoid: a nationwide population‐based cohort study
Authors: Yu Wen‐Ting , Ma Sheng‐Hsiang , Wu Chun‐Ying , Chen Yen‐Ling , Chang Yun‐Ting , Wu Chen‐Yi 
Published: October 2023

SummaryBackgroundStudies have shown that bullous pemphigoid (BP) occurs in patients with chronic kidney disease (CKD). However, the risk of developing BP in patients with CKD remains inconclusive.ObjectiveTo investigate whether CKD increases the risk of BP.MethodsParticipants were recruited from the National Health Insurance Database of Taiwan between 2007 and 2018. Overall, 637,664 newly diagnosed patients with CKD and 637,664 age‐, sex‐, and comorbidity‐matched non‐CKD participants were selected. A competing risk model was used to evaluate the risk of development of BP.ResultsAfter adjusting for age, sex, and comorbid diseases in the multivariate model, CKD was a significant risk factor for BP (adjusted hazard ratio [aHR]: 1.29; 95% confidence interval [CI]: 1.17–1.42; p < 0.001). CKD patients were classified into the dialytic or non‐dialytic groups and compared to non‐CKD participants, and this revealed that patients with dialysis‐dependent CKD had the highest risk of BP (aHR 1.75; 95% CI 1.51–2.03), followed by patients with non‐dialysis‐dependent CKD (aHR 1.20; 95% CI 1.08–1.32).LimitationsWe lacked detailed laboratory data on the severity of CKD.ConclusionsCompared with individuals without CKD, those with CKD had a 1.3‐fold increased risk of BP. Patients with dialysis‐dependent CKD had an even higher BP risk (1.8‐fold).
On Justice, Pedagogy, and Decolonial(Izing) Praxis
Authors: Walsh Catherine E. 
Published: October 2023

AbstractThis paper goes beyond — transcends — “pedagogy as justice,” recognizing that justice, particularly in these present times, may not be enough. Its wager is with pedagogies of and for life; pedagogies that plant and cultivate, that push and enable other modes of living, despite the capitalist‐modern‐colonial‐racist system, beyond the system, and in the system's margins, borders, fissures, and cracks. These pedagogies, as Catherine Walsh argues here, are necessarily tied to and constitutive of decolonial(izing) praxis, a praxis that, while not negating justice, takes us beyond it. The argument here is for the pedagogical‐praxistical work being done now, and yet to be done; the actional thought, thoughtful action, and ongoing creation and construction of an otherwise for existence, for dignity, and for life in these times of multiple entwined pandemic‐viruses, including capitalist greed, systemic racism, heteropatriarchy, and existential‐territorial dispossession in which COVID is/was one more thread of the entwine.
Trajectories of parent well‐being in children with drug‐resistant epilepsy
Authors: Smith Mary Lou , Puka Klajdi , Speechley Kathy N. , Ferro Mark A. , Connolly Mary B. , Major Philippe , Gallagher Anne , Almubarak Salah , Hasal Simona , Ramachandrannair Rajesh , Andrade Andrea , Xu Qi , Leung Edward , Snead O. Carter , Widjaja Elysa 
Published: October 2023

AbstractObjectiveThis longitudinal cohort study aimed to identify trajectories of parent well‐being over the first 2 years after their child's evaluation for candidacy for epilepsy surgery, and to identify the baseline clinical and demographic characteristics associated with these trajectories. Parent well‐being was based on parent depressive and anxiety symptoms and family resources (i.e., family mastery and social support).MethodsParents of 259 children with drug‐resistant epilepsy (105 of whom eventually had surgery) were recruited from eight epilepsy centers across Canada at the time of their evaluation for epilepsy surgery candidacy. Participants were assessed at baseline and 6‐month, 1‐year, and 2‐year follow‐up. The trajectories of parents' depressive symptoms, anxiety symptoms, and family resources were jointly estimated using multigroup latent class growth models.ResultsThe analyses identified three trajectories: an optimal‐stable group with no/minimal depressive or anxiety symptoms, and high family resources that remained stable over time; a mild‐decreasing‐plateau group with mild depressive and anxiety symptoms that decreased over time then plateaued, and intermediate family resources that remained stable; and a moderate‐decreasing group with moderate depressive and anxiety symptoms that decreased slightly, and low family resources that remained stable over time. Parents of children with higher health‐related quality of life, fathers, and parents who had higher household income were more likely to have better trajectories of well‐being. Treatment type was not associated with the trajectory groups, but parents whose children were seizure‐free at the time of the last follow‐up were more likely to have better trajectories (optimal‐stable or mild‐decreasing‐plateau trajectories).SignificanceThis study documented distinct trajectories of parent well‐being, from the time of the child's evaluation for epilepsy surgery. Parents who present with anxiety and depressive symptoms and low family resources do not do well over time. They should be identified and offered supportive services early in their child's epilepsy treatment history.
Interaction between mitochondrial homeostasis and barrier function in lipopolysaccharide‐induced endothelial cell injury
Authors: Zhu Weiwei , Liu Xiaojing , Luo Liqing , Huang Xiao , Wang Xiaozhi 
Published: October 2023

AbstractThis study aimed to investigate the effects of mitochondrial homeostasis on lipopolysaccharide (LPS)‐induced endothelial cell barrier function and the mechanisms that underlie these effects. Cells were treated with LPS or oligomycin (mitochondrial adenosine triphosphate synthase inhibitor) and the mitochondrial morphology, mitochondrial reactive oxygen species (mtROS), and mitochondrial membrane potential (ΔΨm) were evaluated. Moreover, the shedding of glycocalyx‐heparan sulphate (HS), the levels of HS‐specific degrading enzyme heparanase (HPA), and the expression of occludin and zonula occludens (ZO‐1) of Tight Junctions (TJ)s, which are mediated by myosin light chain phosphorylation (p‐MLC), were assessed. Examining the changes in mitochondrial homeostasis showed that adding heparinase III, which is an exogenous HPA, can destroy the integrity of glycocalyx. LPS simultaneously increased mitochondrial swelling, mtROS, and ΔΨm. Without oligomycin effects, HS, HPA levels, and p‐MLC were found to be elevated, and the destruction of occludin and ZO‐1 increased. Heparinase III not only damaged the glycocalyx by increasing HS shedding but also increased mitochondrial swelling and mtROS and decreased ΔΨm. Mitochondrial homeostasis is involved in LPS‐induced endothelial cell barrier dysfunction by aggravating HPA and p‐MLC levels. In turn, the integrated glycocalyx protects mitochondrial homeostasis.
Low‐temperature hydrothermal synthesis of NiEuFe2O4 nanoparticles: Magnetic, thermal, and magneto‐dielectric behavior
Authors: Machakanti Yellanna , Chandra Babu Naidu K. , D Baba Basha , Madunuri Chandrasekhar , N Suresh Kumar , A Ratnamala , Khan Anish 
Published: October 2023

AbstractThe Ni1−xEuxFe2O4 (x = .02–.08) (NEF) nanoparticles are prepared using the low‐temperature hydrothermal method. The X‐ray diffraction patterns evidenced the cubic structure of NEF having the increasing trend of lattice constants from .8971 to .8984 nm as a function of Eu‐content. The microstructure reveals the asymmetrical spheres like nanosized grains and particles. The particle size seemed to be increasing from 67.3 to 103.7 nm with x. The magneto‐dielectric and magneto‐loss natures are studied as a function of frequency and composition at the varying magnetic field of .0–1.5 T. The hysteresis nature of NEF is observed from magnetization versus (M–H) curves. The results ensured that the x = .08 content provided the highest magnetization of 89.03 emu/g. The mass loss (Δm) and transition temperatures are determined using TG–DSC curves. The endothermic and exothermic temperatures are clearly noticed for x = .02–.08.
When workarounds aggravate misfits in the use of electronic health record systems
Authors: van Offenbeek Marjolein A. G. , Vos Janita F. J. , van den Hooff Bart , Boonstra Albert 
Published: October 2023

AbstractThis paper contributes to the IS misfits and workarounds literature by demonstrating how “work system–technology” misfits and workarounds can be mutually related. In the context of electronic health record (EHR) systems, this study examines when misfits experienced between an EHR system and health professionals' work practices lead to workarounds with negative consequences in terms of aggravating misfits. Our qualitative study was conducted in two tertiary hospitals in The Netherlands that had implemented an off‐the‐shelf EHR system. We analysed the “misfit experience → response → consequence” sequences that emerged from interviews complemented with observations and documents. Experienced misfits between the EHR and other work system components induced highly varied responses, among which workarounds. While workarounds can be beneficial, we found occasions where workarounds resulted in aggravated misfits. We conceptualise three underlying misfit‐aggravating EHR‐use patterns emerging from (1) a non‐routine practice's perceived exceptionality, (2) collective separatism in incompatible routine practices, and (3) individual deviancy in routine work practices. These patterns differ in terms of the work practices' routineness, professionals' misfit experiences, and in how this combination provokes an individual or collective workaround that is non‐compliant with both the designed technology use and the organisational intent. To understand how these patterns emerge, we discuss the interplay among work practice routineness, misfit characteristics, and non‐compliant workaround behaviours.
The effect of bed exercises following major abdominal surgery on early ambulation, mobilization, pain and anxiety: A randomized‐controlled trial
Authors: Simsek Yaban Zuleyha , Bulbuloglu Semra , Kapikiran Gurkan , Gunes Huseyin , Kula Sahin Sennur , Saritas Serdar 
Published: October 2023

AbstractThis randomized‐controlled trial aimed to investigate the effect of bed exercises on postoperative anxiety, pain, early ambulation and mobilization. This study was conducted with a randomized‐controlled trial design and in the general surgical clinic of a research and training hospital. A total of 120 patients (60 in the experimental group and 60 in the control group) scheduled for major abdominal surgery took part in the study. The data were collected using a patient information form, the Anxiety Specific to Surgery Questionnaire and the Visual Analog Scale through face‐to‐face interviews. The patients in the experimental group performed 15‐min bed exercises on the day of their operation, as well as on the postoperative first and second days, and the control group underwent only the routinely performed procedures in the clinic. The data were analysed using descriptive statistics, analysis of variance and t‐tests. The sample of our study included major abdominal surgery patients. Ambulation was achieved at a mean time of 4 h earlier in the experimental group. On the postoperative first and second days, the patients in the experimental group had mean mobilization durations that were approximately 2 h longer compared with the patients in the control group. Moreover, the postoperative pain and anxiety levels of the patients in the experimental group were significantly lower than those of the patients in the control group (p < 0.05). We recommend that bed exercises be performed to lower anxiety and pain severity, achieve early ambulation and increase the duration of mobilization among patients following major abdominal surgery.
Dedifferentiated Schwann cells promote perineural invasion mediated by the PACAP paracrine signalling in cervical cancer
Authors: Chen Guoqiang , Zheng Zhen , Sun Hao , You Jiahao , Chu Jing , Gao Jinghai , Qiu Lei , Liu Xiaojun 
Published: October 2023

AbstractPerineural invasion (PNI) has emerged as a key pathological feature and be considered as a poor prognostic factor in cervical cancer. However, the underlying molecular mechanisms are largely unknown. Here, PNI status of 269 cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) samples were quantified by using whole‐slide diagnostic images obtained from The Cancer Genome Atlas. Integrated analyses revealed that PNI was an indicative marker of poorer disease‐free survival for CESC patients. Among the differentially expressed genes, ADCYAP1 were identified. Clinical specimens supported that high expression of PACAP (encoded by ADCYAP1) contributed to PNI in CESC. Mechanistically, PACAP, secreted from cervical cancer cells, reversed myelin differentiation of Schwann cells (SCs). Then, dedifferentiated SCs promoted PNI by producing chemokine FGF17 and by degrading extracellular matrix through secretion of Cathepsin S and MMP‐12. In conclusion, this study identified PACAP was associated with PNI in cervical cancer and suggested that tumour‐derived PACAP reversed myelin differentiation of SCs to aid PNI.
Preference of pear psyllid (Cacopsylla pyri) for specific colour inspires new application in plant protection
Authors: Czarnobai De Jorge Bruna , Meyhöfer Rainer , Jürgens Andreas , Gross Jürgen 
Published: October 2023

AbstractUnderstanding the cues used by insects to select their hosts is essential for developing sustainable control strategies, particularly for plant disease vectors. Pear psyllids (Cacopsylla pyri) are vectors of the bacterial disease pear decline caused by ‘Candidatus Phytoplasma pyri’. Yellow sticky traps are typically used to monitor pest insects, but they are non‐specific and capture many beneficial insects, too. Against the background of improving visual traps, this research aimed to investigate the colour choice behaviour of C. pyri. Our first approach was to screen insect colour preferences by performing choice assays with different LED colour wavelengths in a small‐scale choice arena under controlled conditions. Over six LEDs tested, there was a strong significant preference of C. pyri for green 1 (532 nm) followed by green 2 (549 nm). Yellow (576 nm), orange (593 nm), red 1 (619 nm) and red 2 (633 nm) were less attractive than green. Subsequently, the trapping of pear psyllids was tested in the field using newly developed traps covered with transparent‐coloured PVC sheets with a similar wavelength of the preferred LEDs. Red and completely transparent traps have been used as control and combined in randomized blocks in a pear orchard. Field trials revealed that green traps ranging from 525 to 537 nm attracted significantly more pear psyllids than longer wavelength green (543 nm), red and transparent ones. The construction of specific green‐coloured sticky traps seems promising for improving psyllid trapping, especially during an early infestation at low population densities. Thus, these visual traps should be considered in future and integrated into psyllid monitoring as part of integrated pest management.
Orthodontic tooth extrusion to regenerate missing papilla adjacent to maxillary anterior single implants: A 2‐ to 7‐year retrospective study
Authors: Kan Joseph Y. K. , Rungcharassaeng Kitichai , Yin Shi , Kang Philip , Celenza Frank , Spear Frank , Chung Ji Yeon , Lozada Jaime L. 
Published: October 2023

AbstractIntroductionRegeneration of the missing papilla adjacent to single implants in the esthetic zone has always been challenging, despite advances in vertical hard and soft tissue regeneration. Orthodontic tooth extrusion has been shown to effectively gain alveolar bone and gingival tissue. This retrospective study evaluated the effectiveness of orthodontic tooth extrusion on regenerating missing papilla between existing maxillary anterior single implant and its adjacent tooth.MethodsPatients who underwent orthodontic tooth extrusion to regenerate missing papilla adjacent to a single implant in the esthetic zone were included in this study. The gingival phenotype, orthodontic extrusion movement, proximal bone level, dento‐implant papilla level, facial gingival level, mucogingival junction level, and keratinized tissue width, of the extruded tooth were recorded at pre‐orthodontic extrusion (T0), post‐orthodontic extrusion and retention (T1), and latest follow‐up (T2).ResultsA total of 17 maxillary single tooth had orthodontic tooth extrusion to regenerate missing papilla adjacent to 14 maxillary anterior single implants in 14 patients. After a mean follow‐up time of 48.4 months, implant success rate was 100% (14/14), with none of the orthodontically extruded teeth being extracted. After a mean extrusion and retention period of 14.3 months, a mean orthodontic extrusion movement of 4.62 ± 0.78 mm was noted with a mean proximal bone level gain of 3.54 ± 0.61 mm (77.0% efficacy), dento‐implant papilla level gain of 3.98 ± 0.81 mm (86.8% efficacy), and facial gingival tissue gain of 4.27 mm ± 0.55 mm (93.4% efficacy). A mean keratinized tissue width gain of 4.17 ± 0.49 mm with minimal mean mucogingival junction level change of 0.10 ± 0.30 mm were observed. The efficacy of orthodontic eruption movement on dento‐implant papilla gain was less in the thin (80.5%) phenotype group when compared with that in the thick (91.5%) phenotype group.ConclusionsWithin the confines of this study, orthodontic extrusion is an effective, noninvasive method in regenerating mid‐term stable proximal bone and papilla adjacent to maxillary anterior single implants.Clinical SignificanceThis retrospective study presents a mid‐term result on orthodontic extrusion as a mean to regenerate dento‐implant papilla defect. The extended retention period following orthodontic extrusion showed stable and efficacious proximal bone and papilla gain.
Associations of liver dysfunction with incident dementia, cognition, and brain structure: A prospective cohort study of 431 699 adults
Authors: Gao Pei‐Yang , Ou Ya‐Nan , Wang Hui‐Fu , Wang Zhi‐Bo , Fu Yan , He Xiao‐Yu , Ma Ya‐Hui , Feng Jian‐Feng , Cheng Wei , Tan Lan , Yu Jin‐Tai 
Published: October 2023

AbstractThe relationship between liver dysfunction and dementia has been researched extensively but remains poorly understood. In this study, we investigate the longitudinal and cross‐sectional associations between liver function and liver diseases and risk of incident dementia, impaired cognition, and brain structure abnormalities using Cox proportion hazard model and linear regression model. 431 699 participants with a mean of 8.65 (standard deviation [SD] 2.61) years of follow‐up were included from the UK Biobank; 5542 all‐cause dementia (ACD), 2427 Alzheimer's disease (AD), and 1282 vascular dementia (VaD) cases were documented. We observed that per SD decreases in alanine transaminase (ALT; hazard ratio [HR], 0.917; PFDR <0.001) and per SD increases in aspartate aminotransferase (AST; HR, 1.048; PFDR = 0.010), AST to ALT ratio (HR, 1.195; PFDR <0.001), gamma‐glutamyl transpeptidase (GGT; HR, 1.066; PFDR <0.001), alcoholic liver disease (ALD; HR, 2.872; PFDR <0.001), and fibrosis and cirrhosis of liver (HR, 2.285; PFDR = 0.002), being significantly associated with a higher risk of incident ACD. Restricted cubic spline models identified a strong U‐shaped association between Alb and AST and incident ACD (Pnonlinear <0.05). Worse cognition was positively correlated with AST, AST to ALT ratio, direct bilirubin (DBil), and GGT; negatively correlated with ALT, Alb, and total bilirubin (TBil); and ALD and fibrosis and cirrhosis of liver (PFDR <0.05). Moreover, changes in ALT, GGT, AST to ALT ratio, and ALD were significantly associated with altered cortical and subcortical regions, including hippocampus, amygdala, thalamus, pallidum, and fusiform (PFDR <0.05). In sensitivity analysis, metabolic dysfunction‐associated steatotic liver disease (MASLD) was associated with the risk of ACD and brain subcortical changes. Our findings provide substantial evidence that liver dysfunction may be an important factor for incident dementia. Early intervention in the unhealthy liver may help prevent cognitive impairment and dementia incidence.