bluuebunny/crossref_metadata_2025_split huggingface dataset:
Core Components and Implementation Determinants of Multilevel Service Delivery Frameworks Across Child Mental Health Service Settings
Authors: Moore Stephanie A. , Cooper Jennifer McGrory , Malloy JoAnne , Lyon Aaron R. 
Published: December 2023

AbstractMultilevel service delivery frameworks are approaches to structuring and organizing a spectrum of evidence-based services and supports, focused on assessment, prevention, and intervention designed for the local context. Exemplar frameworks in child mental health include positive behavioral interventions and supports in education, collaborative care in primary care, and systems of care in community mental health settings. Yet, their high-quality implementation has lagged. This work proposes a conceptual foundation for multilevel service delivery frameworks spanning diverse mental health service settings that can inform development of strategic implementation supports. We draw upon the existing literature for three exemplar multilevel service delivery frameworks in different child mental health service settings to (1) identify core components common to each framework, and (2) to highlight prominent implementation determinants that interface with each core component. Six interrelated components of multilevel service delivery frameworks were identified, including, (1) a systems-level approach, (2) data-driven problem solving and decision-making, (3) multiple levels of service intensity using evidence-based practices, (4) cross-linking service sectors, (5) multiple providers working together, including in teams, and (6) built-in implementation strategies that facilitate delivery of the overall model. Implementation determinants that interface with core components were identified at each contextual level. The conceptual foundation provided in this paper has the potential to facilitate cross-sector knowledge sharing, promote generalization across service settings, and provide direction for researchers, system leaders, and implementation intermediaries/practitioners working to strategically support the high-quality implementation of these frameworks.
Radium-223 in women with hormone receptor-positive bone-metastatic breast cancer receiving endocrine therapy: pooled analysis of two international, phase 2, randomized, double-blind, placebo-controlled trials
Authors: Rugo Hope S. , Van Poznak Catherine H. , Neven Patrick , Danielewicz Iwona , Lee Soo Chin , Campone Mario , Chik Jeannie Y. K. , Vega Alonso Estela , Naume Bjørn , Brain Etienne , Siegel Jonathan M. , Li Rui , Uema Deise , Wagner Volker J. , Coleman Robert E. 
Published: December 2023

Abstract
Background
Most women with advanced breast cancer have skeletal metastases. Radium-223 is an alpha-emitting radionuclide that selectively targets areas of bone metastases.

Methods
Two double-blind, placebo-controlled studies of radium-223 were conducted in women with hormone receptor-positive (HR+), bone-predominant metastatic breast cancer. All patients received endocrine therapy (ET), as a single agent of the investigator’s choice (Study A) or exemestane + everolimus (Study B). Patients were randomized to receive radium-223 (55 kBq/kg) or placebo intravenously every 4 weeks for six doses. Accrual was halted following unblinded interim analyses per protocol amendments, and both studies were terminated. We report pooled analyses of symptomatic skeletal event-free survival (SSE-FS; primary endpoint), radiologic progression-free survival (rPFS) and overall survival (OS; secondary), and time to bone alkaline phosphatase (ALP) progression (exploratory).

Results
In total, 382 patients were enrolled, and 196 SSE-FS events (70% planned total) were recorded. Hazard ratios (95% confidence intervals) and nominal p values for radium-223 + ET versus placebo + ET were: SSE-FS 0.809 (0.610–1.072), p = 0.1389; rPFS 0.956 (0.759–1.205), p = 0.7039; OS 0.889 (0.660–1.199), p = 0.4410; and time to bone ALP progression 0.593 (0.379–0.926), p = 0.0195. Radium-223- or placebo-related treatment-emergent adverse events were reported in 50.3% versus 35.1% of patients (grade 3/4: 25.7% vs. 8.5%), with fractures/bone-associated events in 23.5% versus 23.9%.

Conclusions
In patients with HR+ bone-metastatic breast cancer, numeric differences favoring radium-223 + ET over placebo + ET for the primary SSE-FS endpoint were suggestive of efficacy, in line with the primary outcome measure used in the underlying phase 2 studies. No similar evidence of efficacy was observed for secondary progression or survival endpoints. Adverse events were more frequent with radium-223 + ET versus placebo + ET, but the safety profile of the combination was consistent with the safety profiles of the component drugs.
Clinical trial registration numbers
Study A: NCT02258464, registered October 7, 2014.
Study B: NCT02258451, registered October 7, 2014.
The Infarct-Limiting Effect of Remote Ischemic Conditioning in Rats Is Not Affected by Aspirin
Authors: Basalay M. V. , Downey James M. , Davidson S. M. , Yellon D. M. 
Published: December 2023

Abstract
Purpose
Remote ischemic conditioning (RIC) has been shown to be a powerful cardioprotective therapy in animal models. However, a protective effect in patients presenting with acute myocardial infarction has failed to be confirmed. A recent pre-clinical study reported that aspirin which is routinely given to patients undergoing reperfusion therapy blocked the infarct-limiting effect of ischemic postconditioning. The present study was designed to test whether aspirin could also be blocking the infarct-limiting effect of RIC.

Methods
This was investigated in vivo using male Sprague Dawley rats (n = 5 to 6 per group) subjected to either 30 min of regional myocardial ischemia, followed by 120-min reperfusion, or additionally to a RIC protocol initiated after 20-min myocardial ischemia. The RIC protocol included four cycles of 5-min hind limb ischemia interspersed with 5-min reperfusion. Intravenous aspirin (30 mg/kg) or vehicle (saline) was administered after 15-min myocardial ischemia.

Results
RIC significantly reduced infarct size (IS) normalized to the area at risk, by 47%. Aspirin administration did not affect IS nor did it attenuate the infarct-limiting effect of RIC.

Conclusion
Aspirin administration in the setting of myocardial infarction is not likely to interfere with the cardioprotective effect of RIC.
Wear behavior at high temperature of ZrO2–Y2O3 (YSZ) plasma-sprayed coatings
Authors: Franco D. , Vargas F. , López E. , Ageorges H. 
Published: December 2023

AbstractThe wear behavior of two plasma-sprayed zirconia–yttria coatings was studied at high temperatures. Agglomerated and sintered, as well as fused and crushed zirconia–yttria feedstock powders were used to manufacture bimodal and monomodal coatings by atmospheric plasma spraying onto an INCONEL 718 substrate previously coated with a NiCrAlY bond coat. The structure of the coatings was analyzed by SEM on their cross section and surface. The samples were subjected to wear conditions by sliding contact through a ball-on-disk test up to 1000 °C, using an alumina ball 6 mm in diameter as the counterbody, on which a load of 5 N was applied. The samples were rotated during 20000 cycles, reaching a speed of 0.10 m·s−1 at the contact area with the counterbody. The porosity, phase, and mechanical properties were determined before and after wear tests. The results indicate that at 25 °C, both coatings have enough mechanical resistance to withstand the tribological conditions they were exposed to. Therefore, low wear rates were produced by ductile deformation. The tribological conditions became more aggressive as the thermal stresses increased with the test temperature, producing cracking, and detaching particles in the coatings tested at 500 and 750 °C. Consequently, high wear rates related to brittle deformation were obtained. However, the transformation of the amorphous phase to the t′-zirconia phase, produced at 1000 °C, increased the hardness of both coatings and, consequently, their wear resistance; thus, the predominant mechanism of damage was ductile deformation, with wear rates similar to those obtained when the coatings were tested at 25 °C.
Enhanced methylene blue adsorption by double alkali activation of highly porous glass microspheres prepared from waste glass
Authors: Mahmoud Mokhtar , Kraxner Jozef , Elsayed Hamada , Stabile Franco Matías , Michálková Monika , Galusek Dušan , Bernardo Enrico 
Published: December 2023

AbstractThe remediation of water from organic pollutants, such as dyes and related compounds and the reuse of discarded glasses, represents fundamental challenges in highly industrialized countries. Porous glass microspheres have been proposed as efficient adsorbents in wastewater treatment, but their real application is problematic, especially from the perspective of their reuse and recycling. For the first time, the present paper describes the process of preparation and use of highly porous bodies with a specific surface area of nearly 20 m2/g fabricated from alkali activated glass microspheres and applicable for the removal of methylene blue as a model organic dye from wastewater. Alkali activation is applied both as an intermediate step (using 9 M KOH) for the conversion of waste glass into porous microspheres by flame spheroidization process, and as a final step (using 2.5 M NaOH), facilitating low temperature consolidation of the microspheres, and their transformation into porous structures. The experimental adsorption capacity of porous glass microspheres pellet was 122 mg/g. The high correlation coefficient indicates the applicability of Langmuir isotherm adsorption model.
Synthesis of superparamagnetic iron oxide nanoparticles coated with polyethylene glycol as potential drug carriers for cancer treatment
Authors: Peréz D. LLamosa , Puentes I. , Romero G. A. Murillo , Gaona I. M. Saavedra , Vargas C. A. Parra , Rincón R. J. 
Published: December 2023

AbstractCurrent cancer treatments are not selective in delivering drugs to cancer cells, affecting healthy tissues and especially rapidly dividing cells. This work describes the development of superparamagnetic nanoparticles for drug delivery through green synthesis, mediated by Musa paradisiaca peel extract as a stabilizing and reducing agent. The nanoparticles’ structural, morphological, magnetic and chemical properties were evaluated. The XRDs showed a cubic crystal structure with the space group of Fd3m (No. 227), typical of magnetite. Through SEM and TEM, it was determined that the mean size of the nanoparticles was 11.61 nm. FTIR and EDS confirmed the successful synthesis of Fe3O4 nuclei, covered with polyethylene glycol and loaded with doxorubicin. The magnetic properties of the nanocomposites obtained were measured using VSM, evidencing a superparamagnetic behaviour with a Ms = 72.75 emu/g. Finally, MTT assays on the HeLa tumour line showed a 45.5% decrease in cell viability. The determined properties allow the application of the nanocomposite produced as a potential candidate for cancer treatment.
Graphical Abstract
(How) Do Pre-service Teachers Use YouTube Features in the Selection of Instructional Videos for Physics Teaching?
Authors: Bitzenbauer Philipp , Teußner Tom , Veith Joaquin M. , Kulgemeyer Christoph 
Published: December 2023

AbstractThis mixed-methods study examines how pre-service teachers select instructional videos on YouTube for physics teaching. The study focuses on the role of surface features that YouTube provides (e.g., likes, views, thumbnails) and the comments underneath the videos in the decision-making process using videos on quantum physics topics as an example. The study consists of two phases: In phase 1, N = 24 (pre-service) physics teachers were randomly assigned to one of three groups, each covering a different quantum topic (entanglement, quantum tunneling, or quantum computing, respectively). From eight options provided, they selected a suitable video for teaching while their eye movements were tracked using a stationary eye tracker in a laboratory setting, and think-aloud data was collected. In the subsequent phase 2, participants were allowed to freely choose one YouTube video on a second topic of the above-mentioned ones while thinking aloud. The results reveal a significant emphasis on video thumbnails during selection, with over one-third of the fixation time directed towards them. Think-aloud data confirms the importance of thumbnails in decision-making, e.g., as evidenced by a categorization of the study participants’ arguments and thoughts voiced. A detailed analysis identifies that participants did not rely on (content-related) comments despite they have been found to be significantly correlated with the videos’ explaining quality. Instead, decisions were influenced by surface features and pragmatic factors such as channel familiarity. Retrospective reflections through a questionnaire including rating scale items support these observations. Building on the existing empirical evidence, a decision tree is proposed to help teachers identify high-quality videos considering duration, likes, comments, and interactions. The decision tree can serve as a hypothesis for future research and needs to be evaluated in terms of how it can help systematize the process of selecting high-quality YouTube videos for science teaching.
The Fibre Resolved OpticAl and Near-Ultraviolet Czerny–Turner Imaging Spectropolarimeter (francis)
Authors: Jess David B. , Grant Samuel D. T. , Bate William , Liu Jiajia , Jafarzadeh Shahin , Keys Peter H. , Vieira Luís E. A. , Dal Lago Alisson , Guarnieri Fernando L. , Christian Damian J. , Gilliam Doug , Banerjee Dipankar 
Published: December 2023

AbstractThe solar physics community is entering a golden era that is ripe with next-generation ground- and space-based facilities, advanced spectral inversion techniques, and realistic simulations that are becoming more computationally streamlined and efficient. With ever-increasing resolving power stemming from the newest observational telescopes, it becomes more challenging to obtain (near-)simultaneous measurements at high spatial, temporal and spectral resolutions, while operating at the diffraction limit of these new facilities. Hence, in recent years there has been increased interest in the capabilities integral field units (IFUs) offer towards obtaining the trifecta of high spatial, temporal and spectral resolutions contemporaneously. To date, IFUs developed for solar physics research have focused on mid-optical and infrared measurements. Here, we present an IFU prototype that has been designed for operation within the near-ultraviolet to mid-optical wavelength range, which enables key spectral lines (e.g., Ca ii H/K, H$\beta $
β
, Sr ii, Na i D1/D2, etc.) to be studied, hence providing additional spectral coverage to the instrument suites developed to date. The IFU was constructed as a low-budget proof-of-concept for the upcoming $2\text{ m}$
2
m
class Indian National Large Solar Telescope and employs circular cross-section fibres to guide light into a Czerny–Turner configuration spectrograph, with the resulting spectra captured using a high quantum efficiency scientific CMOS camera. Mapping of each input fibre allows for the reconstruction of two-dimensional spectral images, with frame rates exceeding $20\text{ s}^{-1}$
20

s

−
1

possible while operating in a non-polarimetric configuration. Initial commissioning of the instrument was performed at the Dunn Solar Telescope, USA, during August 2022. The science verification data presented here highlights the suitability of fibre-fed IFUs operating at near-ultraviolet wavelengths for solar physics research. Importantly, the successful demonstration of this type of instrument paves the way for further technological developments to make a future variant suitable for upcoming ground-based and space-borne telescope facilities.
A mini-review on in vitro methods for virus elimination from Prunus sp. fruit trees
Authors: Szabó Luca Krisztina , Desiderio Francesco , Kirilla Zoltán , Hegedűs Attila , Várallyay Éva , Preininger Éva 
Published: December 2023

AbstractSeveral viruses are known to infect stone fruit trees and cause serious problems in their cultivation; hence, it is essential to use virus-free and healthy propagation material to establish a plantation. As stone fruit trees are propagated vegetatively, both the scion and the rootstock should be pathogen-free. The traditional method for plant virus eradication is meristem culture after in vivo thermotherapy. Prunus species are extremely sensitive to high temperature and have low regeneration capacity from meristem explants which makes it difficult to apply the conventional method. To avoid the application of meristem culture it has become necessary to search for additional methods. The most widespread elimination methods are based on in vitro shoot cultures. It is a challenge to find an optimal method with high efficacy in virus elimination that has little harmful effect on plantlets. In the present study, we collected the elements of current knowledge about viruses and viroids that are able to infect Prunus species and reviewed recent methods that have been used efficiently to eliminate them from Prunus species, applying thermotherapy alone or in combination with shoot tip excision, chemotherapy, cryotherapy or electrotherapy. The key factors influencing the effectivity of virus elimination procedure and in vitro culture survival are also discussed.
On the Shear-Thinning of Alkanes
Authors: Gao Hongyu , Müser Martin H. 
Published: December 2023

AbstractThe approximate power law dependence of the apparent viscosity of liquids on shear rate is often argued to arise from a distribution of energy barriers. However, recent work on the Prandtl model, which consists of a point mass being dragged by a damped, harmonic spring past a sinusoidal potential, revealed a similar dependence of the friction on velocity as that of many liquids. Here, we demonstrate that this correlation is not only qualitative but can also be made quantitative over a broad temperature range using merely three dimensionless parameters, at least for alkanes, in particular n-hexadecane, at elevated pressure p. These and other observations made on our all-atom alkane simulations at elevated pressure point to the existence of an elementary instability causing shear-thinning. In addition, the equilibrium viscosity shows power law dependence on p near the cavitation pressure but an exponential dependence at large p, while the additional parameter(s) in the Carreau–Yasuda equation compared to other rheological models turn out justifiable.
Do corporate regulations deter or stimulate investment? The effect of the OECD anti-bribery convention on FDI
Authors: Crippa Lorenzo 
Published: December 2023

AbstractCountries prohibit firms’ transnational financial crime by coordinating their regulations under international organizations (IOs). Under these IOs, states threaten to prosecute firms’ foreign misconduct at home. Such threats can help conscript companies to diffuse sustainable business models abroad. This paper studies the effect of corporate criminal regulations on firms’ foreign direct investment (FDI). Critics of these policies claim they push firms’ investment away from host economies where financial crime is more likely to happen. Yet, regulations should also cut informal costs of crime and favor investment. I reconcile these opposed expectations and show they are special cases of the same argument. I claim that the effect of multilateral anti-bribery policies on FDI depends on the level of corruption of the host economy. It is null in non-corrupt countries. It is positive where corruption is moderate: here, laws provide legal leverage to refuse paying bribes and cut corruption costs. The effect is negative where corruption is endemic: here, anti-bribery laws expose firms to additional regulatory costs. I support the argument with multiple evidence. Company-level data on investment by 3871 firms between 2006 and 2011 show that regulated corporations have a $$27\%$$

27
%

higher probability of investing in moderately corrupt economies than unregulated firms, which plummets to $$-52\%$$

-
52
%

in extremely corrupt countries. A synthetic counterfactual design using country-dyadic FDI flows corroborates this finding. Results show that regulatory policies harmonized by IOs change international competition for FDI in ways that do not necessarily harm regulated firms.
Multiple myeloma in people of working age in Czechia, Germany, and Poland: findings from a qualitative interview study
Authors: Forbat Liz 
Published: December 2023

Abstract
Purpose
The study sought to understand the experiences of working age adults with myeloma and their partner/family members, living in Czechia, Germany, and Poland.

Methods
Qualitative interviews were conducted with 36 working age adults living with myeloma, and three family members. Data were collected from May to October 2022. Thematic analysis was applied to the data.

Results
Healthcare and state support within each country are described. The degree of work engagement was informed by patients’ symptom burden, treatment needs, state financial aid, and family/financial obligations. Many did not conceptualise their status as involving ‘return to work’ as they had continued to be engaged with their jobs throughout. For some, remote working enabled them to manage treatments/side-effects and their job, while avoiding infection. In some cases, patients did not tell their employer or colleagues about their illness, for fear of discrimination.

Conclusion
While experiences varied between countries, common across accounts was a struggle to balance ongoing treatments with employment, at a time when participants were expected to finance their own households and maintain their income and roles.
Implications for Cancer Survivors
To improve quality of life, clinical discussions around treatment decision-making should take into account patients’ attitudes/approach to work, type of work engaged in, and other activities considered important to them. European Union and national cancer plans should set out optimum standards for employers, to ensure an equitable benchmark for how employees are supported. Such approaches would improve legal protections and better enforcement of employer policies to accommodate patients’ limitations in the workplace.