bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of multiple models of diffusion-weighted imaging to predict hepatic lymph node metastases in colorectal liver metastases patients
Authors: Zhu Hai-Bin , Zhao Bo , Li Xiao-Ting , Zhang Xiao-Yan , Yao Qian , Sun Ying-Shi 
Published: January 2024

BACKGROUND
About 10%-31% of colorectal liver metastases (CRLM) patients would concomitantly show hepatic lymph node metastases (LNM), which was considered as sign of poor biological behavior and a relative contraindication for liver resection. Up to now, there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM, except for pathology examination of lymph node after resection.
AIM
To compare the ability of mono-exponential, bi-exponential, and stretched-exponential diffusion-weighted imaging (DWI) models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to surgery.
METHODS
In this retrospective study, 97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging, including DWI with ten b values before and after chemotherapy. Various parameters, such as the apparent diffusion coefficient from the mono-exponential model, and the true diffusion coefficient, the pseudo-diffusion coefficient, and the perfusion fraction derived from the intravoxel incoherent motion model, along with distributed diffusion coefficient (DDC) and α from the stretched-exponential model (SEM), were measured. The parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups. A nomogram was constructed to predict the hepatic lymph node status. The reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation coefficient.
RESULTS
Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes. A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients, with an area under the curve of 0.873. Furthermore, parameters from SEM showed substantial repeatability.
CONCLUSION
The developed nomogram, incorporating the pre-treatment DDC and the short axis of the largest lymph node, can be used to predict the presence of hepatic LNM in CRLM patients undergoing chemotherapy before surgery. This nomogram was proven to be more valuable, exhibiting superior diagnostic performance compared to quantitative parameters derived from multiple b values of DWI. The nomogram can serve as a preoperative assessment tool for determining the status of hepatic lymph nodes and aiding in the decision-making process for surgical treatment in CRLM patients.
Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity
Authors: Li Yi-Jie , Baumert Brittney O , Stratakis Nikos , Goodrich Jesse A , Wu Hao-Tian , He Jing-Xuan , Zhao Yin-Qi , Aung Max T , Wang Hong-Xu , Eckel Sandrah P , Walker Douglas I , Valvi Damaskini , La Merrill Michele A , Ryder Justin R , Inge Thomas H , Jenkins Todd , Sisley Stephanie , Kohli Rohit , Xanthakos Stavra A , Baccarelli Andrea A , McConnell Rob , Conti David V , Chatzi Lida 
Published: January 2024

BACKGROUND
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases in children and adolescents. NAFLD ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis (NASH), wherein hepatocellular inflammation and/or fibrosis coexist with steatosis. Circulating microRNA (miRNA) levels have been suggested to be altered in NAFLD, but the extent to which miRNA are related to NAFLD features remains unknown. This analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in adolescents.
AIM
To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with NAFLD.
METHODS
This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery study. Intra-operative core liver biopsies were collected from participants and used to characterize histological features of NAFLD. Plasma samples were collected during surgery for miRNA profiling. A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq platform. We examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age, sex, race, and other key covariates. Ingenuity Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of NAFLD.
RESULTS
We identified 16 upregulated plasma miRNAs, including miR-193a-5p and miR-193b-5p, and 22 downregulated plasma miRNAs, including miR-1282 and miR-6734-5p, in adolescents with NAFLD. Moreover, 52, 16, 15, and 9 plasma miRNAs were associated with NASH, fibrosis, ballooning degeneration, and lobular inflammation, respectively. Collectively, 16 miRNAs were associated with two or more histological features of NAFLD. Among those miRNAs, miR-411-5p was downregulated in NASH, ballooning, and fibrosis, while miR-122-5p, miR-1343-5p, miR-193a-5p, miR-193b-5p, and miR-7845-5p were consistently and positively associated with all histological features of NAFLD. Pathway analysis revealed that most common pathways of miRNAs associated with multiple NAFLD features have been associated with tumor progression, while we also identified linkages between miR-122-5p and hepatitis C virus and between miR-199b-5p and chronic hepatitis B.
CONCLUSION
Plasma miRNAs were associated with NAFLD features in adolescent with severe obesity. Larger studies with more heterogeneous NAFLD phenotypes are needed to evaluate miRNAs as potential biomarkers of NAFLD.
Sistemas Educativos: tendencias y desafíos
Authors: Ramos Hernández Rosa Raquel 
Published: January 2024

En este artículo se proporciona una revisión documental de los sistemas educativos, a partir de su estructura, organización, normatividad, características y problemáticas; además de establecer los diferentes niveles formativos en que se encuentran articulados, de acuerdo con la Clasificación Internacional Normalizada de la Educación (CINE). Se realiza especial énfasis en los sistemas educativos de países como: España, Argentina. Bolivia, Colombia y Venezuela, estableciendo comparaciones entre ellos; las cuales permiten identificar aspectos comunes y establecer las diferencias entre sus modelos, ante los múltiples factores que inciden en la trayectoria educativa de cada país.
De la misma manera, se realiza un recorrido informativo sobre las tendencias de los sistemas educativos y el análisis de diez artículos científicos que abordan el tema, los cuales permiten comprender de una mejor forma, las particularidades de los mismos, determinando que actualmente existe una gran variedad de tendencias de sistemas educativos, que buscan conseguir modelos exitosos, para mejorar la calidad educativa y el desarrollo económico de sus contextos.
Por último, se abordan los desafíos de los sistemas educativos, el rastreo indica, que son de diversa índole, pero que tienen retos comunes asociados a la cuarta revolución, en contexto con la educación 4.0 y Steam; que a su vez son consecuentes con el desarrollo sostenible, en el marco de la transformación digital que afecta a todos los sectores de la sociedad. Los sistemas educativos procuran responder a los retos que demanda la situación actual y futura, preparando a los estudiantes en habilidades y destrezas adicionales a las recibidas tradicionalmente, para que se adapten al cambio, con talento y competencias pertinentes al nuevo escenario.
Three-dimensional Velocity Fields of the Solar Filament Eruptions Detected by CHASE
Authors: Qiu Ye , Li Chuan , Guo Yang , Li Zhen , Ding Mingde , Kong Linggao 
Published: January 2024

Abstract
The eruption of solar filaments, also known as prominences appearing off limb, is a common phenomenon in the solar atmosphere. It ejects massive plasma and high-energy particles into interplanetary space, disturbing the solar-terrestrial environment. It is vital to obtain the three-dimensional velocity fields of erupting filaments for space-weather predictions. We derive the three-dimensional kinematics of an off-limb prominence and an on-disk filament, respectively, using the full-disk spectral and imaging data detected by the Chinese Hα Solar Explorer (CHASE). It is found that both the prominence and the filament experience a fast semicircle-shaped expansion at first. The prominence keeps propagating outward with an increasing velocity until escaping successfully, with the south leg of the prominence finally moving back to the Sun in a swirling manner. For the filament, the internal plasma falls back to the Sun in a counterclockwise rotation in the late ejection, matching the failed eruption without a coronal mass ejection. During the eruptions, both the prominence and the filament show material splitting along the line-of-sight direction, revealed by the bimodal Hα spectral profiles. For the prominence, the splitting begins at the top and gradually spreads to almost the whole prominence with a fast blueshift component and a slow redshift component. The material splitting in the filament is more fragmental. As shown by the present results, the CHASE full-disk spectroscopic observations make it possible to systematically study the three-dimensional kinematics of solar filament eruptions.
Evaluating Pediatric Ophthalmic Care Using Sentiment Analysis of Physician Review Sites
Authors: Vought Victoria , Vought Rita , Sharma Rahul , Razdan Geena , Zhu Lyndon , Sutariya Riya , Wagner Rudolph S. 
Published: January 2024

Purpose:
To assess patient satisfaction within pediatric ophthalmology and identify trends in patient sentiment.

Methods:
Pediatric ophthalmologists in the United States were identified using the American Association for Pediatric Ophthalmology and Strabismus member directory. Demographic data were recorded using publicly available websites. Online written reviews and Stars ratings were obtained from Healthgrades.com. A sentiment analysis package, Valence Aware Dictionary for Sentimental Reasoning (VADER), was used to generate a compound score of reviews, and word frequency analyses were applied.

Results:

A total of 377 pediatric ophthalmologists (2,640 online reviews) were evaluated. Physicians received an average of 4.22/5 Stars and a compound sentiment score of 0.56, indicating positive sentiment. No differences in scores were observed by gender or location, although physicians with fewer years in practice had higher Stars ratings compared to peers (
P
< .001). The three most common words in the word frequency analysis of all reviews were “surgery,” “staff,” and “time,” with heavy emphasis on bedside manner and addressing patient concerns.

Conclusions:
This study demonstrates overall high patient satisfaction in pediatric ophthalmology care, with differences in sentiment based on physician demographic features. The study highlights that patient perspective is influenced by non-clinical features of care. These data may be used by pediatric ophthalmologists seeking to improve health care delivery.

[
J Pediatr Ophthalmol Strabismus
. 2024;61(3):211–218.]
De l'histoire, du sport, et des images
Authors: Laffage-Cosnier Sébastien 
Published: January 2024

Comment devient-on historien à l’université lorsqu’on s’intéresse au domaine marginal, et considéré comme superficiel, des images de sport ? Comment légitimer la culture visuelle sportive dans un contexte universitaire qui a tendance à hiérarchiser les objets de recherche en fonction de leur prestige social et académique ?À la croisée d’une réflexion ego-historique et d’une fiction littéraire, cet itinéraire d’un historien du sport nous invite à suivre les méandres d’une trajectoire professionnelle singulière. Il révèle l’influence des déterminismes sociaux et le poids des blessures nourrissant des résiliences. Il dévoile des mécanismes de résistance aux contraintes exercées par le système dominant ou encore d’étranges concours de circonstances. Prenant forme à la fois dans les stades et sur les estrades, les engagements politiques et humanistes de l’auteur prennent vie dans ce récit original et incisif.
Aux intersections de la géographie sociale et de la géohistoire. Dimensions sociales, spatiales et temporelles
Authors: Dumont Isabelle 
Published: January 2024

Au-delà du titre assez général, cette contribution propose des hypothèses de travail pour affronter la question du caractère indissociable des trois dimensions. Elle interroge trois notions chères à la géographie : l’espace, la frontière et l’échelle. Loin d’être incompatibles ou concurrentes, les deux approches, celle de la géographie sociale et celle de la géohistoire, semblent plutôt complémentaires : pour l’une, donner plus de profondeur à l’analyse de l’espace de la géographie sociale et pour l’autre, accorder plus d’attention aux interactions d’échelles en géohistoire. L’approche géohistorique prend davantage en considération l’épaisseur temporelle alors que l’immédiateté temporelle est plus caractéristique de la géographie sociale. Des objets de recherche différents ? Des méthodologies différentes ? Oui, probablement, mais cela ne signifie pas que ces différences doivent être vues comme des obstacles. L’idée de base n’est pas de juxtaposer les deux approches mais au contraire de les associer dans la construction de l’objet de recherche et surtout dans le processus d’analyse. Examiner l’évolution historique des phénomènes socio-spatiaux permettrait, d’une part de distinguer les éléments structurels et conjoncturels, et d’autre part de tenter d’expliquer comment et pourquoi ces phénomènes se sont différenciés dans des territoires divers. Dans l’autre sens, il est important de prêter davantage attention aux expressions socio-spatiales variées, inégales et hiérarchisées, prenant en considération les aspects fonctionnels du quotidien (habiter, travailler, etc.) et les interactions qui les influencent. La géographie, comme science sociale, rend compte de l’organisation évolutive de l’espace en tant que résultante des dynamiques « naturelles », des dynamiques socio-économiques, des idéologies politiques successives, mais surtout des tensions et des contrastes qui se produisent à des niveaux multiscalaires ou transcalaires (tenant compte de l’indissociabilité des dimensions spatiale, sociale et temporelle).
La géographie sociale en Italie
Authors: Lombardi Daniela 
Published: January 2024

Cette contribution vise à discuter le processus d’affirmation de la géographie sociale en Italie. Dans un premier temps, le faible intérêt de la communauté scientifique italienne vis-à-vis de la discipline est manifeste, discipline dont elle n’a souvent qu’une connaissance partielle sur ce qui constitue sa spécificité. Par ailleurs, le nombre de scientifiques qui s’en occupent est modeste. Ce travail parcourt les premiers pas, difficiles, de la discipline, en cernant les précurseurs et les acteurs, et en insistant sur quelques pôles universitaires dans lesquels s’est développée une sorte de géographie sociale non déclarée. Il analyse ensuite le rapport entre la géographie et la géographie sociale, à travers l’examen attentif d’importants travaux théorico-méthodologiques publiés depuis vingt-cinq ans. Se dessine un panorama d’ombres et de lumières : en effet, si dans certains cas la géographie sociale conquiert un espace en fin de compte significatif, dans d’autres elle est, en somme, ignorée. Dans tous les cas, l’étude montre qu’à partir des années 1980, parallèlement à une forte ouverture vers les théories sociales, on enregistre un crédit majeur accordé à la discipline. Aujourd’hui, pourtant, il est encore difficile d’évaluer quel est le poids réel de la géographie sociale dans le paysage italien ; comme il est également difficile de rendre compte du nombre de chercheurs qui la pratiquent, car ceux qui le déclarent sont encore peu nombreux. En Italie, on la pratique souvent sans l’étiqueter comme telle : on a cherché à identifier la géographie sociale « là où on ne dit pas que ça en est ». Ont tout d’abord été analysées les contributions parues dans les principales revues géographiques italiennes ; ensuite, ont été identifiés les lieux et les scientifiques qui, selon nous, pratiquent effectivement la géographie sociale.
Exploring the relationship between ambient sulfur dioxide and semen quality parameters: A systematic review and meta-analysis
Authors: Bahreiny Seyed Sobhan , Aghaei Mojtaba , Dabbagh Mohammad Reza , Ghorbani Hamid , Javidan Moslem , Fard Reza Mohammadpour 
Published: January 2024

Objective:
To investigate the relationship between ambient sulfur dioxide (SO2) exposure and semen quality parameters.

Methods:
A systematic literature search was conducted to identify relevant studies investigating the association between SO2 exposure and semen quality parameters. This search encompassed the timeframe from January 2000 to May 2023 and included electronic databases such as Web of Science, Google Scholar, PubMed, Cochrane, and Scopus. Pooled effect estimates with 95% confidence intervals (CI) were calculated using percent changes (PC). The meta-analysis included seven studies with 6 711 participants and 15 087 semen samples.

Results:
The results revealed a significant negative association between ambient SO2 exposure and certain semen quality parameters. In particular, SO2 exposure was associated with a significant decrease in progressive motility (PC=0.032; 95% CI: -0.063 to -0.001; P=0.044) and sperm concentration (PC = -0.020; 95% CI: -0.036 to -0.005; P=0.012). However, no statistically significant associations were observed for total sperm count (PC = -0.038; 95% CI: -0.079 to 0.003; P=0.070), seminal fluid volume (PC = -0.009; 95% CI: -0.048 to -0.030; P=0.662) and sperm motility (PC = -0.17; 95% CI: -0.363 to 0.022; P=0.830). In addition, the results of the subgroup analysis revealed specific variables that were associated with the decrease in relevant sperm parameters.

Conclusions:
This systematic review and meta-analysis provides compelling evidence supporting a consistent negative association between exposure to ambient SO2 and semen quality parameters.
Assessment of corneal parameters in patients with rheumatoid arthritis
Authors: Özkaya Dilek , Doğru Atalay , Baykal Tuba 
Published: January 2024

Purpose:To assess the corneal parameters in rheumatoid arthritis (RA) patients.Methods:We enrolled 64 patients with RA (32 receiving biologic and 32 receiving conventional drugs) and 32 healthy subjects. Keratometric values (anterior flat [K1], steep [K2], and mean keratometry [Km]), corneal thickness from the pupil center (CCT), apex (ACT), and the thinnest point (TCT), and corneal volume (CV) were measured and compared between the groups.Results:K1, K2, and Km values were significantly higher in the RA group (P = 0.013,P= 0.048,P= 0.027, respectively). The means of CCT, ACT, TCT, and CV were significantly lower in RA patients (P < 0.001,P< 0.001,P< 0.001,P= 0.011, respectively). When we divided RA patients into two groups according to the treatment and compared them to controls, the differences in K1, CCT, ACT, TCT and CV were significant (P = 0.030,P= 0.005,P= 0.001,P= 0.001,P= 0.034, respectively). K1 and CV values of RA-biologic group were similar to the control group (P= 0.205 andP= 0.127, respectively).Conclusion:Biologic agents contribute to the improvement of K1 and CV values in patients with RA.
Comparison of visual outcomes in patients implanted with Tecnis Eyhance ICB00 and 1-Piece ZCB00 monofocal intraocular lenses
Authors: Singh Gagandeep , Sidhharthan K S , Reddy Jagadeesh K , Sundaram Vandana , Thulasidas Mithun 
Published: January 2024

Purpose:
To compare the visual outcomes and monocular defocus curve of a new monofocal Tecnis Eyhance IOL (Tecnis ICB00) with Tecnis 1 single piece (ZCB00).

Methods:
Eighty patients diagnosed with cataract were divided into two groups: Tecnis ICB00 (n = 40) and ZCB00 (n = 40). The visual outcome was evaluated using the following parameters: uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), corrected distance visual acuity (CDVA), distance corrected intermediate visual acuity (DCIVA), corrected near visual acuity (CNVA), uncorrected visual acuity contrast sensitivity (UVACS), best-corrected visual acuity contrast sensitivity (BCVACS), manifest refraction, and defocus curve and was compared at the 6th week and 3 months after surgery.

Results:
The UIVA and UNVA were significantly (P < 0.05) better in ICB00 as compared with ZCB00 at 6 weeks and 3 months postoperative. The DCIVA was significantly better in ICB00 as compared with ZCB00 at 3 months postoperative (−0.015 ± 0.04 vs. 0.01 ± 0.020; P = 0.01). Regarding contrast sensitivity, UVACS and BCVACS were significantly better in ICB00 as compared with ZCB00 at 6 weeks and 3 months postoperative (P < 0.05). The defocus curves showed that the mean visual acuity of the ICB00 group was significantly better than that of the ZCB00 group at between – 0.5 D and – 2.50 D of defocus.

Conclusion:
In patients undergoing cataract surgery, Eyhance ICB00 provided better intermediate vision as compared with ZCB00.
Evidence supporting correlation between aging and dengue severity: A retrospective analysis on the 2010 dengue outbreak in Brazil
Authors: Ávila Thiago V , Ferraz Fernanda O , Nunes Leonardo V , Alessandri Ana L , Souza Passos Ingredy B , Costa Vivian V , Teixeira Mauro M , Souza Daniele da G 
Published: January 2024

Objective:
The aim of this study is to explore the role of aging and non-communicable diseases (NCDs) as potential risk factors for severe clinical manifestations of dengue. This investigation was conducted within a cohort of patients from the 2010 epidemic in Belo Horizonte, Brazil.

Methods:
A total of 144 subjects diagnosed with dengue were categorized into two groups, representing the early and late (critical) stages of the disease. Further stratification was performed based on age, distinguishing between young and aged subjects. NCD subjects were also divided into young and aged groups. The symptomatology, previous clinical history, age, and presence of NCDs were inquired. Blood samples were collected for the analysis of platelet, soluble tumor necrosis factor receptor 1 (sTNFR1), and aspartate aminotransferase (AST) levels. The Mann-Whitney test was explored for the comparison of two groups, whereas the Kruskal-Wallis test was used for the analysis of differences among the multiple groups. Categorical variables were examined by Chi-square test. Correlation assessments were conducted using binary logic regression analysis with a 95% confidence interval. P<0.05 was considered statistically significant.

Results:
Compared to the younger subjects with NCDs, aged subjects exhibited a more severe form of dengue during the critical phase. The presence of NCDs was not associated with a worse dengue outcome in younger individuals, suggesting that aging itself maybe an important contributor to the severity of dengue.

Conclusions:
In the studied cohort, we emphasize that aging is a significant factor associated with severe manifestations of dengue. While we do not discard the potential role of NCDs in exacerbating disease progression, it may be more prominently impact the aged groups.