bluuebunny/crossref_metadata_2025_split huggingface dataset:
Civil Aviation Policies and Practices in Turkey in a Global Context Through Sustainable Aviation
Authors: Haksevenler Betul Hande Gursoy , Temel Nazife Umran , Topal Yelda Erden 
Published: November 2023

AbstractThe negative environmental effects of global civil aviation growth since the 19th century lead to the emergence of the “sustainable aviation” concept. This study aims to determine the current status of sustainability discussions in developing Turkish civil aviation and its alignment with global sustainable aviation policies. The research data are collected through document analysis and key expert interviews. Document analysis is to review reports on sustainable aviation and to compare two cases of AirFrance‐KLM and Turkish Airlines. Semi‐structured interviews are conducted with key experts from airline companies, public institutions, and subsidiary services in the Turkish aviation sector. The analysis results are presented under the themes of “institutional, conceptual, Turkey's current situation, motivations, role of international organizations, cooperation and coordination, problems and obstacles.” The results show that the Turkish civil aviation industry is enthusiastic about catching up with international standards and is successful in keeping up with the latest technologies. The private sector is leading the sector by targeting global competitiveness. Current deficiencies stem from legislation, incentives, obligations, resources, and environmental awareness. The main contribution is to be the first source and guide for future studies that aim to shed light on policymaking in Turkey as an emerging country case.
Balancing climate resilience and adaptation for Caribbean Small Island Developing States (SIDS): Building institutional capacity
Authors: Galaitsi Stephanie E. , Corbin Christopher , Cox Shelly-Ann , Joseph Genora , McConney Patrick , Cashman Adrian , Springer Cletus , Keenan Jesse , Cummings Christopher L. , Trump Benjamin D. , Linkov Igor 
Published: November 2023

Abstract
Although the Caribbean's Small Island Developing States (SIDS) minimally contribute to global greenhouse gas emissions, they face disproportionate climate risks and are particularly susceptible to systemic economic threats posed by climate change and subsequent increases in climate variability. Historically, strategic programs and investments have sought to develop more robust and adaptive engineered systems to absorb climate threats. However, such initiatives are limited and under-resourced in the SIDS' context. This article reviews existing climate strategies in the Caribbean and then critically examines current gaps and barriers relating to climate impact knowledge, needs, and implementation. This examination can assist Caribbean SIDS leadership to identify opportunities to transition from a vulnerability-reducing mindset to one of resilience and transformative adaptation to improve long-term economic outlooks, social welfare, and environmental stewardship despite recurring and escalating climate risks. Integr Environ Assess Manag 2024;20:1237–1255. © 2023 SETAC
Key Points
When critical systems fail, the effects can cascade into other systems and timescales that would not have otherwise been affected. Small Island Developing States understand the need to go further: they seek to “bounce forward” in order to adapt systems to changing social, economic, and environmental conditions. Resilience-by-design is defined by as the endogenous origination and resourcing of a system's interventions.
Inhibition of the Cyclin K‐CDK12 complex induces DNA damage and increases the effect of androgen deprivation therapy in prostate cancer
Authors: Frei Katharina , Schecher Sabrina , Daher Tamas , Hörner Nina , Richter Jutta , Hildebrand Ute , Schindeldecker Mario , Witzel Hagen R. , Tsaur Igor , Porubsky Stefan , Gaida Matthias M. , Roth Wilfried , Tagscherer Katrin E. 
Published: November 2023

AbstractAndrogen deprivation therapy (ADT) is the mainstay of the current first‐line treatment concepts for patients with advanced prostate carcinoma (PCa). However, due to treatment failure and recurrence investigation of new targeted therapeutics is urgently needed. In this study, we investigated the suitability of the Cyclin K‐CDK12 complex as a novel therapeutic approach in PCa using the new covalent CDK12/13 inhibitor THZ531. Here we show that THZ531 impairs cellular proliferation, induces apoptosis, and decreases the expression of selected DNA repair genes in PCa cell lines, which is associated with an increasing extent of DNA damage. Furthermore, combination of THZ531 and ADT leads to an increase in these anti‐tumoral effects in androgen‐sensitive PCa cells. The anti‐proliferative and pro‐apoptotic activity of THZ531 in combination with ADT was validated in an ex vivo PCa tissue culture model. In a retrospective immunohistochemical analysis of 300 clinical tissue samples we show that Cyclin K (CycK) but not CDK12 expression correlates with a more aggressive type of PCa. In conclusion, this study demonstrates the clinical relevance of the CycK‐CDK12 complex as a promising target for combinational therapy with ADT in PCa and its importance as a prognostic biomarker for patients with PCa.
Peritoneal metastases from gastric cancer in a nationwide cohort: Incidence, treatment and survival
Authors: Rijken Anouk , Pape Marieke , Simkens Geert A. , de Hingh Ignace H. J. T. , Luyer Misha D. P. , van Sandick Johanna W. , van Laarhoven Hanneke W. M. , Verhoeven Rob H. A. , van Erning Felice N. 
Published: November 2023

AbstractThe aims of this study were to investigate incidence, risk factors and treatment of synchronous or metachronous peritoneal metastases (PM) from gastric cancer and to estimate survival of these patients using population‐based data. Patients diagnosed with gastric cancer in 2015 to 2016 were selected from the Netherlands Cancer Registry. The incidence of synchronous and metachronous PM were calculated. Multivariable regression analyses were performed to identify factors associated with the occurrence of PM. Treatment and survival were compared between patients with synchronous and metachronous PM. Of 2206 patients with gastric cancer, 741 (34%) were diagnosed with PM. Of these, 498 (23%) had synchronous PM. The cumulative incidence of metachronous PM in patients who underwent potentially curative treatment (n = 675) was 22.8% at 3 years. A factor associated with synchronous and metachronous PM was diffuse type histology. Patients diagnosed with synchronous PM more often received systemic treatment than patients with metachronous PM (35% vs 18%, respectively, P < .001). Median overall survival was comparable between synchronous and metachronous PM (3.2 vs 2.3 months, respectively, P = .731). Approximately one third of all patients with gastric cancer are diagnosed with PM, either at primary diagnosis or during 3‐year follow‐up after potentially curative treatment. Patients with metachronous PM less often received systemic treatment than those with synchronous PM but survival was comparable between both groups. Future trials are warranted to detect gastric cancer at an earlier stage and to examine strategies that lower the risk of peritoneal dissemination. Also, specific treatment options for patients with gastric PM should be further investigated.
Ultrasonography to Access Diaphragm Dysfunction and Predict the Success of Mechanical Ventilation Weaning in Critical Care
Authors: Marques Marta Rafael , Pereira José Manuel , Paiva José Artur , de Casasola‐Sánchez Gonzalo García , Tung‐Chen Yale 
Published: November 2023

IntroductionWeaning failure is common in mechanically ventilated patients, and whether ultrasound (US) can predict weaning outcome remains controversial. This review aims to evaluate the diaphragmatic function measured by US as a predictor of weaning outcome.MethodsPubMed was searched to identify original articles about the use of diaphragmatic US in ICU patients. A total of 61 citations were retrieved initially; available data of 26 studies were included in this review.ResultsTo assess diaphragmatic dysfunction in adults, six studies evaluated excursion, five evaluated thickening fraction, and both in nine. Despite heterogeneity in the diagnostic accuracy of diaphragm US among the studies, the sonographic indices showed good diagnostic performance for predicting weaning outcome.ConclusionsDiaphragmatic US can be a useful and accurate tool to detect diaphragmatic dysfunction in critically ill patients and predict weaning outcome.
The Efficacy of Budesonide as Intrapolyp Injection Agent in the Management of Type 2 CRSwNP
Authors: Elzayat Saad , Lasheen Hesham , Gehad Ibrahim , El‐Deeb Mohamed E. , Soltan Islam , Aouf Mohammad M. , Elgendy Ahmed 
Published: November 2023

ObjectivesTo assess the efficacy and safety of budesonide as an intrapolyp injection in chronic rhinosinusitis with nasal polyps (CRSwNP) in comparison to control and systemic steroids.MethodIn a prospective double‐blinded controlled randomized clinical trial, 150 patients with CRSwNP were divided into 3 groups in a ratio 1:1:1 where group (A) was given oral prednisolone 1 mg/kg tapered daily for 2 weeks, group (B) was given budesonide intrapolyp injection weekly for 5 consecutive weeks, and group (C) was given intrapolyp injection with saline as the control group. Patients were assessed upon Sinonasal Outcome Test (SNOT‐22) score, Total Nasal Polyp score (TNPS), Serum IgE, absolute eosinophilic count, and morning cortisol level before treatment, 1 week and 6 months after completing their treatment protocol.ResultsSNOT 22 score improved significantly in all groups compared to those at baseline. Reduction in the oral and injection groups was much greater than the control group (P2 < 0.001), (P3 < 0.001), and the same trend concerning TNPS score (P2 < 0.001), (P3 < 0.001) but with no significant change in the control group.ConclusionIntrapolyp steroid injection is considered a safe and effective method in nasal polyposis with limited side effects in comparison to systemic steroids. Using Budesonide as an agent for intrapolyp injection appears to be promising. It's advisable in patients with multiple relapses or high‐risk patients to avoid repeated courses of oral steroids.Level of Evidence2 Laryngoscope, 134:2085–2092, 2024
Heterogeneous trajectories of depression and resilience following limb amputation
Authors: McGiffin Jed N. , Ehde Dawn M. , Williams Rhonda M. , Bonanno George A. 
Published: November 2023

AbstractObjectiveTo identify longitudinal trajectories of depression in the first 6 months following limb loss and to explore baseline predictors of trajectories, including pain and demographic factors. A secondary aim was to evaluate whether trajectories of depression were associated with elevated symptoms of posttraumatic stress (PTS) at 6 months.DesignSecondary longitudinal data analysis of an inception cohort study of persons with new‐onset limb loss. Participants completed assessments at three intervals (initial, 3 months, and 6 months).SettingHospitalized care, acute rehabilitation, ambulatory care, and community.ParticipantsParticipants were recruited from consecutive cases of amputation surgery in a metropolitan hospital system over a period of 4 years (2002–2007). The final sample (n = 203) was predominantly White (79.3%) and male (78.8%) with an average age of 49.4 years (standard deviation [SD] = 14.6).Main Outcome Measure(s)Depression was assessed via the Patient Health Questionnaire‐9 (PHQ‐9); posttraumatic stress symptoms were measured via the PTSD checklist– Civilian Version (PCL‐C).ResultsFour trajectories of depression were identified via Latent Growth Mixture Modeling: Resilience (73.2%), Chronic Depression (11.2%), Emerging Depression (8.9%), and Recovery (6.7%). Average pain intensity significantly predicted trajectory membership. Membership in the Chronic Depression class predicted elevated 6‐month PTS compared to all other classes; membership in the Resilience class predicted lower PTS than in the Chronic and Emerging Depression classes but did not differentiate from the Recovery trajectory.ConclusionsFindings reveal that the course of depression post‐amputation is heterogenous, with varying profiles of symptom development, maintenance, and remission. A majority of individuals were classified as Resilient, whereas a substantial minority of individuals developed clinically significant depression between 3 and 6 months (Emerging Depression), suggesting that early screening during acute care may be insufficient. We detected a significant prospective relation between depression trajectories and distal PTS, advancing the potential clinical utility of trajectory modeling as a risk surveillance tool.
Complexation and evolution of cis‐prenyltransferase homologues in Cinnamomum kanehirae deduced from kinetic and functional characterizations
Authors: Liu Jia‐Jin , Liang Po‐Huang 
Published: November 2023

AbstractEukaryotic dehydrodolichyl diphosphate synthases (DHDDSs), cis‐prenyltransferases (cis‐PTs) synthesizing precursors of dolichols to mediate glycoprotein biosynthesis require partners, for eample Nus1 in yeast and NgBR in animals, which are cis‐PTs homologues without activity but to boost the DHDDSs activity. Unlike animals, plants have multiple cis‐PT homologues to pair or stand alone to produce various chain‐length products with less known physiological roles. We chose Cinnamomum kanehirae, a tree that contains two DHDDS‐like and three NgBR‐like proteins from genome analysis, and found that one DHDDS‐like protein acted as a homodimeric cis‐PT to make a medium‐chain C55 product, while the other formed heterodimeric complexes with either one of two NgBR homologues to produce longer‐chain products. Both complexes were functional to complement the growth defect of the yeast rer2 deficient strain at a higher temperature. From the roles for the polyprenol and dolichol biosynthesis and sequence motifs, their homologues in various species were compared to reveal their possible evolutionary paths.
Evaluation of the stability of physiological and behavioral resistance to imidacloprid in the house fly (Musca domestica L.) (Diptera: Muscidae)
Authors: Hubbard Caleb B. , Gerry Alec C. , Murillo Amy C. 
Published: November 2023

AbstractBACKGROUNDThe house fly (Musca domestica L.) is a synanthropic fly species commonly associated with confined animal facilities. House fly control relies heavily on insecticide use. Neonicotinoids are currently the most widely used class of insecticide and have been formulated into granular fly baits since 2002. Physiological resistance to imidacloprid in house flies has been observed to be unstable and decline over time without continual selection pressure, indicating that resistance has a fitness cost to individuals in the absence of exposure to insecticides. The stability of behavioral resistance to imidacloprid in the house fly has not been evaluated. In the current study, we assess the stability of physiological and behavioral resistance in house flies to imidacloprid over time.RESULTSPhysiological susceptibility to imidacloprid varied significantly among three house fly strains examined, with WT‐15 exhibiting the greatest susceptibility to imidacloprid with an LC50 and LC95 of 109.29 (95.96–124.49) μg g−1 and 1486.95 (1097.15–2015.23) μg g−1, respectively. No significant differences in survival were observed across 30 generations of a house fly strain (BRS‐1) previously selected for behavioral resistance to imidacloprid with percentage survival ranging from 93.20% at F0 in 2020 to 96.20% survival at F30 in 2022.CONCLUSIONThese results have significant implications for the management of house flies exhibiting behavioral resistance in field settings. It appears that standard resistance management tactics deployed to reduce the prevalence of physiological resistance, such as rotating or temporarily discontinuing the use of specific insecticides, may not lead to reduced behavioral resistance to imidacloprid. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A plural knowledges model to support sustainable management of dryland rivers in western India
Authors: Brierley Gary , Sahoo Sonam , Danino Michel , Fryirs Kirstie , Pandey Chhavi N. , Sahoo Ramendra , Khan Sana , Mohapatra Pranab , Jain Vikrant 
Published: November 2023

AbstractDirect and indirect human disturbances present major challenges to sustainable management of dryland rivers, impacting upon their role as critical lifelines in arid and semiarid regions. This paper presents an overview of changing human–river relations, knowledges and practices in the management of dryland rivers in western India over the last 4500 years. In ancient times, traditional knowledges underpinned local water harvesting techniques that worked with nature. Subsequent imposition of external values and knowledge frameworks in colonial times applied a command‐and‐control ethos that asserted human authority over rivers. Postindependence, development programmes in the second half of the 21st century further accentuated this legacy, with profound implications for river health. Discipline‐bound approaches to river restoration in recent decades have failed to address these concerns. Using the Sabarmati catchment (~20,000 km2) as a case study, we develop a holistic, transdisciplinary approach that integrates traditional place‐based knowledges and practices alongside scientific understandings and the generative potential of Big Data to show how a plural knowledges model can support proactive and precautionary approaches to sustainable river management.
Polanyi and the Other Alternative Food Network: What San Francisco‐Based Multi‐Level Marketers of “Healthy” Food Tell UsAboutValues in Market Societies
Authors: Kristiansen Mathias Levi Toft , Gillette Maris Boyd 
Published: November 2023

AbstractRecent decades have witnessed the proliferation of alternative food networks (AFNs) in the US and Europe. While social scientists classify heterogenous practices as AFNs, their participants share the desire to work against the existing food system, and efforts to access food from outside this system. Many analysts have captured these features of AFNs by using concepts from Karl Polanyi's The Great Transformation. Yet while Polanyi's framework has been productive, it has also contributed to binary representations of alternative food movements as either advancing non‐market values or in service to commodification and hegemony. We scrutinize San Francisco‐based independent contractors who sell food alternatives and health supplements produced by a multi‐level marketing company we call NatureRise. The marketers of NatureRise products are committed to working against an industrial food system that they consider corrupt. They promote food alternatives that they regard as more natural than food in the conventional system, and embed sales in face‐to‐face relations in which a family‐like concern for human wellbeing is expressed. Yet, they also engage in sales for what Polanyi calls “the motive of gain.” Our case highlights a shortcoming in Polanyi's thought, one that characterizes many social analyses, while supporting the continued relevance of his work.
High Signal‐to‐Noise Ratio Event‐Driven MEMS Motion Sensing
Authors: Mousavi Mohammad , Alzgool Mohammad , Davaji Benyamin , Towfighian Shahrzad 
Published: November 2023

AbstractTwo solutions for improving MEMS triboelectric vibration sensors performance in contact‐separation mode are reported experimentally and analytically. Triboelectric sensors have mostly been studied in the mesoscale. The gap variation between the electrodes induces a potential difference that represents the external vibration. Miniaturizing the device limits the sensor output because of the limited gap. This work offers a warped MEMS diaphragm constrained on its edges. The dome‐shaped structure provides one order of magnitude larger displacement after contact‐separation than standard designs resulting in one order of magnitude greater voltage and signal‐to‐noise‐ratio. Second, micro triboelectric sensors do not operate unless the external vibration is sufficiently forceful to initiate contact between layers. The proposed constraints on the edge of the diaphragm provide friction during periodic motion and generate charges. The combination of the warped diaphragm and boundary constraints instead of serpentine springs increases the charge density and voltage generation. The mechanical properties and electrical output are thoroughly investigated including nonlinearity, sensitivity, and signal‐to‐noise ratio. A sensitivity of 250 mV g−1 and signal‐to‐noise‐ratio of 32 dB is provided by the presented device at resonance, which is very promising for event‐driven motion sensors because it does not require signal conditioning and therefore simplifies the sensing circuitry.
Conclusion
Authors: Ratschiller Nasim Linda Maria 
Published: November 2023

AbstractThe conclusion highlights the results presented in the book by offering both additional empirical examples and new avenues for their interpretation. Rather than merely summarising the content, the conclusion discusses results and open questions along three dimensions: “metropolitan reflections,” “lines of hygiene” and “shifts of meanings.” The first point highlights how knowledge acquired in colonial encounters gave rise to a new scientific discipline—tropical medicine and hygiene—and shaped metropolitan approaches to public health. The section on “lines of hygiene” shows that purity, health and cleanliness were not clearly defined, solid concepts but explicit and implicit efforts to draw lines of difference. The last point traces the diverse meanings of hygiene from a temporal, spatial and epistemological perspective. Actors, institutions and networks from the religious, scientific and colonial spaces of knowledge interacted more or less between 1885 and 1914, and thus changed the substance of hygiene.
Soothing Weak Nerves: Tropical Anxieties, Missionary Guidance and Moral Hygiene
Authors: Ratschiller Nasim Linda Maria 
Published: November 2023

AbstractThis chapter argues that the contemporary image of the tropics as a site of jeopardy and trial offered an effective framework to preach the Basel Mission’s pious code of conduct to a broader audience. The personal regimen recommended in the medical literature on tropical hygiene around 1900 focussed on asceticism, self-discipline and temperance. These measures were congruent with the proscriptions of Pietist purity, underlining the continued belief in a connection between morality and disease. This puritan dimension of tropical hygiene allowed the Basel medical missionaries to position themselves as experts on the matter and mould scientific and colonial debates with their religious logic. They enjoyed extensive moral authority among the colonial public, not only advising how the sick should be treated but also prescribing healthy diets, behaviours and lifestyles. Although many of the debates surrounding tropical hygiene were carried out in medical journals and other specialised publications, their influence ranged far beyond the disciplinary boundaries of tropical medicine, gaining currency in wider social and political contexts.