bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Somatic, Audio, Visual, and Intelligent (SAVI) Learning Model to Improve Student Learning Outcomes on Dynamic Fluid Material
Authors: Serevina Vina , Heriyoso Angestu , Liandari Eka 
Published: October 2023

Abstract
This research was conducted to improve learning outcomes and the quality of the learning process to teach students grade XI physics through the implementation of somatic, audio, visual, and intelligent (SAVI) learning model and the use of PowerPoint presentations, as a medium for students at class XI SCIENCE 3 Public Senior High School 107 Jakarta. Data collection is done in two ways, namely tests and observations, and for media assessment, quality is assessed through the assessment rubric. From observation of the activity of students and teachers, activity increased from 72.50% to 85.50%. Students’ learning outcomes can improve from 75.5 in cycle I to 79.5 in cycle II with the minimum completeness criteria is 77.0. So, it already passed the minimum completeness criteria. It can be concluded the implementation of somatic, audio, visual, and intelligent (SAVI) learning model can improve student learning outcomes and the quality of the learning process on dynamic fluid material.
Needs Analysis of Comic as Science Teaching Material for Junior High School Students
Authors: Syaflita Dina , Alvi Ria Rizkia , Adila Fekie , Jaya Adi Putra M. 
Published: October 2023

AbstractLow students’ interest in reading has an impact on their low knowledge. Teaching materials need to be presented in an interesting way to attract students’ interest in reading. The aim of this study is to identify problems and needs of students and science teachers related to teaching materials in the form of comics. The type of this research is a survey. The questionnaire was filled out by 141 junior high school students and 8 science teachers from 4 different schools. The analysis technique used was descriptive analysis. The results of this study show that most students like reading comics and are interested in using them as one of the teaching materials for science subjects. The frequency of students reading the usual teaching materials is not very high. This is also supported by the statement of science teachers who say that students’ interest in reading the usual textbooks is moderate to low. Therefore, teaching materials need to be presented in a more attractive form for children. Children find it easier to understand the material with accompanying illustrations. Regarding science literacy competence, the existing teaching materials have not supported this competence well.
Preliminary research on the development of PS-BK learning model in basic electronics courses
Authors: Hufri  , Ellizar  , Lufri  , Triani F 
Published: October 2023

Abstract
This research is motivated by the importance of increasing the competence of human resources in facing global competition in the current 4.0 revolution era. Therefore, learning models that can prepare students to master critical thinking, problem-solving, communication, collaboration, and creative and innovative thinking skills must be developed. This preliminary study aims to identify the elements necessary for the development of the PS-BK (Integrated Problem Solving and Creative Thinking) learning model in basic electronics courses. The Plomp development design’s preliminary research stage is this one. The needs and context analysis, literature review, and conceptual theory development make up this preliminary research. Data collection techniques are using questionnaires and observation sheets. The data analysis technique used is the percentage technique. The learning outcomes obtained by dividing the value with the highest percentage, on the B- and C+ grades, indicate that the majority of lecturers use conventional models so that learning activities have not maximally involved students in building knowledge and developing their thinking skills, over the preceding three years (2019, 2020, and 2021).. Based on needs and context analysis as well as analysis of student characteristics in basic electronics learning, it is known that PS-BK learning models need to be developed in improving students’ abilities and developing creative thinking ability.
Synchrotron light source X-ray detection with Low-Gain Avalanche Diodes
Authors: Mazza S.M. , Saito G. , Zhao Y. , Kirkes T. , Yoho N. , Yerdea D. , Nagel N. , Ott J. , Nizam M. , Leite M. , Moralles M. , Sadrozinski H.F.-W. , Seiden A. , Schumm B. , McKinney-Martinez F. , Giacomini G. , Chen W. 
Published: October 2023

Abstract
Low Gain Avalanche Diodes (LGADs) represent the
state-of-the-art in timing measurements and will instrument the
future Timing Detectors of ATLAS and CMS for the High-Luminosity
LHC. While initially conceived as a sensor for charged particles,
the intrinsic gain of LGADs makes it possible to detect low-energy
X-rays with good energy resolution and excellent time resolution
(tens of picoseconds). Using the Stanford Synchrotron Radiation
Lightsource (SSRL) at SLAC, several LGADs designs were characterized
with energies from 5 to 70 keV. The SSRL provides 10 ps pulsed
X-ray bunches separated by 2 ns intervals with an energy dispersion
(ΔE/E) of 10-4. LGADs from Hamamatsu Photonics (HPK)
and Brookhaven National Laboratory (BNL) with different thicknesses
ranging from 20 μm to 50 μm and different gain layer
designs were read out using fast amplification boards and digitized
with a high bandwidth and high sampling rate oscilloscope. PIN
devices from HPK and AC-LGADs from BNL were characterized as well. A
systematic and detailed characterization of the devices' energy
linearity, resolution, and time resolution as a function of X-ray
energy was performed for different biasing voltages at room
temperature and are reported in this work. The charge collection and
multiplication mechanism were simulated using Geant4 and TCAD
Sentaurus, providing an important handle for interpreting the data.
Understanding the soil water dynamics during excess and deficit rainfall conditions over the core monsoon zone of India
Authors: Goswami Mangesh M , Mujumdar Milind , Singh Bhupendra Bahadur , Ingale Madhusudan , Ganeshi Naresh , Ranalkar Manish , Franz Trenton E , Srivastav Prashant , Niyogi Dev , Krishnan R , Patil S N 
Published: October 2023

Abstract
Observations of soil moisture (SM) during excess and deficit monsoon seasons between 2000 to 2021 present a unique opportunity to understand the soil water dynamics (SWD) over core monsoon zone (CMZ) of India. This study aims to analyse SWD by investigating the SM variability, SM memory (SMM), and the coupling between surface and subsurface SM levels. Particularly intriguing are instances of concurrent monsoonal extremes, which give rise to complex SWD patterns. Usually, it is noted that a depleted convective activity and persistence of higher temperatures during the pre-monsoon season leads to lower SM, while monsoon rains and post-monsoon showers support the prevalence of higher SM conditions. The long persistent dry spells during deficit monsoon years enhances the Bowen ratio (BR) due to the high sensible heat fluxes. On the other hand, the availability of large latent heat flux during excess monsoon and post-monsoon seasons tend to decrease the BR. This enhancement or reduction in BR is due to evapotranspiration (ET), which influences the SWD by modulating the surface—subsurface SM coupling. The surface and subsurface SM coupling analysis for CMZ exhibits significant distinction in the evolution of wet and dry extremes. SM variations and persistence time scale is used as an indicator of SMM, and analysed for both surface and subsurface SM observation levels. Evidently, subsurface SM exhibits remarkably prolonged memory timescales, approximately twice that of surface SM. Furthermore, we dissect SWD linked to wet and dry extremes by analysing annual soil water balance at a local site in Pune, India. Our findings reveal that ET and deep drainage on annual scale are modulated largely by number of break events during the monsoon season. In essence, our study underscores the significance of surface–subsurface SM observations in unravelling the intricate tapestry of SWD.
Local symmetry groups for arbitrary wavevectors
Authors: Maggio Emanuele , Smolyanyuk Andriy , Tomczak Jan M 
Published: October 2023

Abstract
We present an algorithm for the determination of the local symmetry group for arbitrary k-points in 3D Brillouin zones. First, we test our implementation against tabulated results available for standard high-symmetry points (given by universal fractional coordinates). Then, to showcase the general applicability of our methodology, we produce the irreducible representations for the ‘non-universal high-symmetry’ points, first reported by Setyawan and Curtarolo (2010 Comput. Mater. Sci.
49 299). The present method can be regarded as a first step for the determination of elementary band decompositions and symmetry-enforced constraints in crystalline topological materials.
The arbitrary deprivation of dual nationality in investment arbitration
Authors: Mezgravis Andrés A 
Published: October 2023

Abstract
Recently, some investment tribunals have held that the doctrine of ‘effective and dominant nationality’ is a ‘relevant rule of international law’ according to which dual nationals can only invoke the protection of the respective bilateral investment treaty to the extent that they invoke their effective and dominant nationality to sue the State of their non-dominant nationality. However, the idea that multiple nationalities are an evil that must be avoided in the interest of States has ceased to be valid. In 1960, less than a third of states accepted dual nationality. By 2018, three-quarters of states allowed their nationals to possess another nationality. We are currently witnessing a paradigm shift that some arbitrators are still reluctant to acknowledge. When an investment tribunal claims to apply the ‘effective and dominant nationality principle’ what it is actually doing is refusing to recognize one of the claimant’s nationalities. The non-recognition of a nationality that does not correspond to an express legal norm and does not respond to a legitimate purpose is arbitrary and, therefore, should be prohibited as it violates a fundamental human right.
InCliniGene enables high-throughput and comprehensive in vivo clonal tracking toward clinical genomics data integration
Authors: Merelli Ivan , Beretta Stefano , Cesana Daniela , Gennari Alessandro , Benedicenti Fabrizio , Spinozzi Giulio , Cesini Daniele , Montini Eugenio , D’Agostino Daniele , Calabria Andrea 
Published: October 2023

Abstract
High-throughput clonal tracking in patients under hematopoietic stem cell gene therapy with integrating vector is instrumental in assessing bio-safety and efficacy. Monitoring the fate of millions of transplanted clones and their progeny across differentiation and proliferation over time leverages the identification of the vector integration sites, used as surrogates of clonal identity. Although γ-tracking retroviral insertion sites (γ-TRIS) is the state-of-the-art algorithm for clonal identification, the computational drawbacks in the tracking algorithm, based on a combinatorial all-versus-all strategy, limit its use in clinical studies with several thousands of samples per patient. We developed the first clonal tracking graph database, InCliniGene (https://github.com/calabrialab/InCliniGene), that imports the output files of γ-TRIS and generates the graph of clones (nodes) connected by arches if two nodes share common genomic features as defined by the γ-TRIS rules. Embedding both clonal data and their connections in the graph, InCliniGene can track all clones longitudinally over samples through data queries that fully explore the graph. This approach resulted in being highly accurate and scalable. We validated InCliniGene using an in vitro dataset, specifically designed to mimic clinical cases, and tested the accuracy and precision. InCliniGene allows extensive use of γ-TRIS in large gene therapy clinical applications and naturally realizes the full data integration of molecular and genomics data, clinical and treatment measurements and genomic annotations. Further extensions of InCliniGene with data federation and with application programming interface will support data mining toward precision, personalized and predictive medicine in gene therapy.
Database URL: https://github.com/calabrialab/InCliniGene
Exploring microbial diversity in Greenland Ice Sheet supraglacial habitats through culturing-dependent and -independent approaches
Authors: Jaarsma Ate H , Sipes Katie , Zervas Athanasios , Jiménez Francisco Campuzano , Ellegaard-Jensen Lea , Thøgersen Mariane S , Stougaard Peter , Benning Liane G , Tranter Martyn , Anesio Alexandre M 
Published: October 2023

Abstract
The microbiome of Greenland Ice Sheet supraglacial habitats is still underinvestigated, and as a result there is a lack of representative genomes from these environments. In this study, we investigated the supraglacial microbiome through a combination of culturing-dependent and -independent approaches. We explored ice, cryoconite, biofilm, and snow biodiversity to answer: (1) how microbial diversity differs between supraglacial habitats, (2) if obtained bacterial genomes reflect dominant community members, and (3) how culturing versus high throughput sequencing changes our observations of microbial diversity in supraglacial habitats. Genomes acquired through metagenomic sequencing (133 high-quality MAGs) and whole genome sequencing (73 bacterial isolates) were compared to the metagenome assemblies to investigate abundance within the total environmental DNA. Isolates obtained in this study were not dominant taxa in the habitat they were sampled from, in contrast to the obtained MAGs. We demonstrate here the advantages of using metagenome SSU rRNA genes to reflect whole-community diversity. Additionally, we demonstrate a proof-of-concept of the application of in situ culturing in a supraglacial setting.
Mannose oligosaccharide recognition of CGL1, a mannose-specific lectin containing DM9 motifs from Crassostrea gigas, revealed by X-ray crystallographic analysis
Authors: Hatakeyama Tomomitsu , Masuda Kazuki , Kudo Mizuki , Tanaka Koshi , Takeuchi Ayaka , Unno Hideaki 
Published: October 2023

Abstract
CGL1 is a mannose-specific lectin isolated from the Pacific oyster Crassostrea gigas, and it belongs to the DM9 domain protein family. Each subunit of the CGL1 dimer consists of a tandem repeat of DM9 motifs, which were originally found in the Drosophila melanogaster genome. The CGL1 protomer contains two carbohydrate-binding sites: a high-affinity site A and a low-affinity site B. An assay using dendrimers containing oligomannose from yeast (Saccharomyces cerevisiae) revealed that CGL1 exhibited significantly higher affinity for mannotetraose (Man4) compared to mannobiose (Man2) and mannotriose (Man3). To investigate its oligomannose-recognition mechanism, X-ray crystallographic analyses of CGL1/oligomannose complexes were performed. In the CGL1/Man2 and CGL1/Man3 complexes, Manα1–2Man and Manα1–2Manα1–2Man, respectively, were primarily bound to site A, interacting with the non-reducing mannose residue. On the other hand, in the CGL1/Man4 crystal, Man4 (Manα1–2Manα1–2Manα1–6Man) was bound at both site A and site B at the non-reducing and reducing ends, thus linking adjacent CGL1 molecules with crystallographic symmetry. These findings suggest that CGL1 can recognize both the non-reducing and reducing mannose residues of mannose oligosaccharides at its two distinct carbohydrate-binding sites. This enables efficient complex formation, making CGL1 a pattern-recognition molecule capable of recognizing diverse structures of mannose-containing carbohydrate chains.
Factors influencing timing of puberty in Mexican gray wolves (Canis lupus baileyi)
Authors: Asa Cheryl S , Bauman Karen L 
Published: October 2023

AbstractThe reintroduced population of Mexican gray wolves (Canis lupus baileyi) continues to rely on a carefully managed captive breeding program. Although success of that program depends on detailed knowledge of reproductive processes, age of puberty has not been determined. This study assessed male puberty status (presence of sperm in ejaculates), maintained in nine US facilities, during their first breeding season. Variables possibly associated with puberty were also evaluated. There was a significant effect of body weight, testis size, facility latitude, and date of collection, whereas a statistical trend was found for age and inbreeding coefficient. Social factors, including being housed with sire, had no effect. Over half the males in their first breeding season were producing sperm, although in some cases sperm quality was poor, suggesting possible infertility. Although there was no minimum body weight associated with presence of sperm, likelihood increased with increasing body weight, highlighting a possible critical role for nutrition. The trend for sperm production in males collected later in the breeding season and at lower latitudes suggests that later collections, especially at higher latitudes, might reveal a higher percentage of pubertal males. These results have potential implications for breeding program management and introduce the possibility that more wild gray wolves than previously thought might produce sperm during their first year, even if they do not sire young.
CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis
Authors: Cheng Haixia , Hua Lingyang , Tang Hailiang , Bao Zhongyuan , Xu Xiupeng , Zhu Hongguang , Wang Shuyang , Jiapaer Zeyidan , Bhatia Roma , Dunn Ian F , Deng Jiaojiao , Wang Daijun , Sun Shuchen , Luan Shihai , Ji Jing , Xie Qing , Yang Xinyu , Lei Ji , Li Guoping , Wang Xianli , Gong Ye 
Published: October 2023

Abstract
Meningioma is one of the most common primary neoplasms in the central nervous system, but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive meningiomas. There is hence an urgent demand to decrypt the biological and molecular landscape of malignant meningioma. Here, through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients, we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma, and a high CBX7 expression level predicts a favorable prognosis in meningioma patients. CBX7 restoration significantly induces cell cycle arrest and inhibits meningioma cell proliferation. iTRAQ-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative phosphorylation. The mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase, USP44, consequently attenuates c-MYC-mediated transactivation of LDHA transcripts, and further inhibits glycolysis and subsequent cell proliferation. More importantly, the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma patients. Altogether, our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.
The Fire Adapted Communities Pathways Tool: Facilitating Social Learning and a Science of Practice
Authors: Paveglio Travis B , Schmidt Annie , Medley-Daniel Michelle 
Published: October 2023

Abstract
Wildfire science, policy, and practice lack systematic means for “tailoring” fire adaptation practices to socially diverse human populations and in ways that aggregate existing lessons. This article outlines the development and initial operationalization of the Fire Adapted Communities Pathways Tool, an inductive set of processes that help facilitate dialogue about needs and priorities for wildfire adaptation strategies across ownership boundaries or partners. We outline the stages and considerations organized by the tool, including how its components build from decades of social science and practitioner experience facilitating fire adaptation choices among communities spanning the United States. We then outline examples for how the pathways tool provides opportunities to reflect and respond to the needs of diverse human populations implementing fire adaptation in distinct places. Finally, we discuss how the tool can help advance a “science of practice” for wildfire adaptation by promoting social learning or gathering monitoring information at multiple scales.
Study Implications: The pathways tool provides a series of empirically informed processes, choices, and engagement tactics designed to foster shared agreement about the best practices for wildfire adaptation across site-specific local conditions. We outline how the tool can advance adaptation processes for a variety of users, including (1) a community oriented planning process that will help reinforce or catalyze collective action about fire management, (2) a systematic approach for monitoring differential progress toward development of fire-adapted communities, and (3) a potential feedback mechanism that informs programmatic foci or allocation of future resources across potential actions designed for diverse social conditions.
First constraints on the strength of the extragalactic magnetic field from γ-ray observations of GRB 221009A
Authors: Dzhatdoev Timur A , Podlesnyi Egor I , Rubtsov Grigory I 
Published: October 2023

ABSTRACT
The extragalactic magnetic field (EGMF) could be probed with γ-ray observations of distant sources. Primary very high-energy γ-rays from these sources absorb on extragalactic background light photons, and secondary electrons/positrons from the pair production acts create cascade γ-rays. These cascade γ-rays could be detected with space γ-ray telescopes such as Fermi-LAT. The γ-ray burst GRB 221009A was an exceptionally bright transient well suited for intergalactic γ-ray propagation studies. Using publicly available Fermi-LAT data, we obtain upper limits on the spectrum of delayed emission from GRB 221009A during the time windows of 10, 30, and 90 d after the burst, and compare these with model spectra calculated for various EGMF strengths B, obtaining constraints on B. We show that the values of B between 10−20 and 10−18 G are excluded.