bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin Use Is Associated With Improved Outcomes in Critically Ill Patients With Acute Pancreatitis: A Retrospective Matched Cohort Study
Authors: Dai Juan-juan , He Yan , Ma Gang , Hu Yang-yang , Jiang Ming-jie 
Published: October 2023

Background Severe acute pancreatitis (SAP) has a mortality of 30% with no current targeted therapy. The potential protective effect of insulin on AP has been reported and needs to be confirmed. Thus, we aim to examine the effect of insulin treatment on the outcome of AP patients. Methods A retrospective study was performed using data from the Medical Information Mart for Intensive Care (MIMIC) database. Kruskal–Wallis test, t-tests, and Pearson's chi-squared test were used to compare differences between groups. Propensity score matching and further nearest neighbor matching were used to construct a matched cohort. Cox proportional hazards regression analyses, logistic regression analyses, and the doubly robust estimation method were used to assess the relationship between insulin use and mortality. Results Nine hundred patients were enrolled in the final analysis. Insulin was associated with better outcomes in AP patients admitted to ICU, and could act as an independent predictor for 30-day mortality (HR = 0.36, 95% CI = 0.24-0.55). Subgroup analysis showed that AP patients with heart failure or without kidney disease or respiratory failure may not benefit from insulin treatment. Conclusions Insulin treatment is independently associated with lower 30-day mortality in AP patients, except for those with heart failure or without kidney disease or respiratory failure.
Trends and Themes in the Study of Value in Orthopedic Surgery: A Systematic Review
Authors: Abdel Khalik Hassaan , Nijjar Manraj S. , Soeder Jack , Lameire Darius L. , Johal Herman 
Published: October 2023

Background: The study of value in orthopedic surgery aims to maximize health outcomes gained per unit cost through various health economic tools but is fragmented across various subspecialties and geographies. Therefore, it is difficult to ascertain whether this research methodology is being used to its full potential across all orthopedic subspecialties and geographies. Purpose: We sought to assess the distribution of prior health economics literature in orthopedic surgery across subspecialties and geographies. The secondary aim was to identify pertinent methodologic trends that may affect the conclusions drawn. Methods: A systematic review utilizing 3 electronic databases (Medline, Embase, and Web of Science) was performed. Inclusion criteria included prior systematic reviews assessing economic analyses across all orthopedic surgery subspecialities published between 2010 and April 24, 2021. The quality of evidence was assessed using the Assessment of Multiple Systematic Review tool. Data were qualitatively analyzed. Results: In the 44 studies included, arthroplasty (36.4%) and spine (31.8%) were the most represented subspecialties. Almost half of studies originated from the United States (45.5%), followed by the United Kingdom (18.2%). Health economic models were most commonly from the perspective of the health care or hospital system (40.5%), followed by the societal perspective (23.5%), and the payer perspective (14.8%). Conclusions: The study of value in orthopedic surgery is not uniformly leveraged across all subspecialties and geographies. Methodologically, the societal perspective was inadequately represented, despite orthopedic pathologies often incurring significant indirect costs (eg, time off work, rehabilitation expenses).
Resilience and Patient-Reported Outcomes in Patients Undergoing Orthopedic Hand Surgery
Authors: Anderson Justin C. , Milam Rachel J. , Drayer Nicholas J. , Zalneraitis B. Holt , Hood Debra K. , Shin Emily H. , Kang Daniel G. 
Published: October 2023

Background: Previous studies have examined the impact of resiliency on postoperative outcomes in other orthopedic domains, but none to date have done so for hand surgery. Methods: We performed a retrospective analysis of prospectively collected data of patients undergoing hand surgery at a single institution. We included patients with complete preoperative outcomes scores and 6-month follow-up. All patients completed the Brief Resilience Scale (BRS), Disabilities of the Arm, Shoulder, and Hand (DASH) Score, Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), Veterans RAND 12-Item Health Survey (VR-12), and Numeric Rating Scale (NRS) for pain. Patients were stratified into high-resiliency (HR) and low-resiliency (LR) groups based on the preoperative BRS score, and outcomes between groups were compared. Results: We identified 91 patients who underwent hand procedures and completed full preoperative and postoperative outcomes measures. There were no observed preoperative differences between the groups in all outcomes scores except the VR-12 Mental Component Score. Postoperatively, the HR group had superior DASH, QuickDASH, and VR-12 (mental and physical component) scores than the LR group. Postoperative pain, as measured by the NRS, was significantly lower in the HR group despite there being no preoperative difference. A larger percentage of patients in the HR group met the minimal clinically important difference in all outcomes except for the VR-12 Mental Component Scores. Conclusions: Patients with high preoperative resilience appear to have significantly better clinical outcomes following hand surgery with superior DASH, QuickDASH, and VR-12 scores at 6-month follow-up. Type of Study/Level of Evidence: Prognostic study/Level IV evidence.
Validity and reliability study of the Turkish Personal Report of Intercultural Communication Apprehension Scale: a revised scale
Authors: Türkoğlu Nihan , Kavuran Esin , Ay Eda 
Published: October 2023

Background: Intercultural communication is one of the most important competencies of nurses that enhances the health-care process and increases the quality of care in multicultural environments. Aims: This study was conducted to revise the Turkish Personal Report of Intercultural Communication Apprehension Scale. Methods: This methodological study was conducted between November and December 2021 with 321 female and 96 male university students (mean age 20.78 ± 2.04 (min. = 17, max. = 37)). Revision of the Turkish Personal Report of Intercultural Communication Apprehension Scale included factor analysis, test–retest analysis for reliability, correlation-based item analysis, Cronbach’s alpha internal consistency analysis and confirmatory factor analysis. Results: Analysis results showed that the scale was composed of 12 items and explained 56.79% of the total variance. Cronbach’s alpha value of the scale was found to be 0.88. Internal consistency analysis included item–total score correlations; the values were found to range between −0.59 and 0.79 and the 14th item with negative item–total score correlations was excluded from the scale. Conclusion: The results of this study show that the revised Turkish Personal Report of Intercultural Communication Apprehension Scale is a valid and reliable tool.
A comparison of the sociodemographic, medical, and psychosocial characteristics of adolescents and young adults diagnosed with cancer recruited in-person and online: A Canadian cross-sectional survey
Authors: Bender Jacqueline L , Akinnibosun Rukayyah , Puri Natasha , D’Agostino Norma , Drake Emily K , Tsimicalis Argerie , Howard A Fuchsia , Garland Sheila N , Chalifour Karine , Gupta Abha A 
Published: October 2023

Introduction Adolescents and young adults diagnosed with cancer (AYAs) are under-represented in research. The Internet and social media could increase the reach of recruitment efforts but may impact sample characteristics. This study evaluated the characteristics of AYAs recruited in-person at an urban hospital versus the Internet in terms of their sociodemographic and medical characteristics, and psychosocial wellbeing, and offers recommendation for increasing the inclusivity and representativeness of research samples. Methods Participant data from a cross-sectional survey of AYAs in Canada were evaluated. In-person hospital recruitment used a registry to identify patients attending ambulatory clinics. Internet recruitment included notices on hospital, team members’, and community partners’ social media channels, and email newsletters. Independent sample t-tests and Chi-squared tests were used to identify differences in participant sociodemographic, medical, and psychosocial characteristics based on recruitment source. Results Of 436 participants, 217 (49.8%) were recruited in-person and 219 (50.2%) online. Online participants were more likely: to be white ( p < .001), women ( p < .001), and Canadian-born ( p < .001); to speak English at home ( p < .001), live alone ( p = .001) and live in rural settings ( p = .014); and to be farther from diagnosis ( p = .023), diagnosed with breast cancer ( p < .001), and cancer free ( p < .001) compared to the hospital sample. Online participants also reported higher anxiety, depression, and loneliness ( p < .001), and lower social support (p < .001), self-efficacy for coping with cancer ( p < .001), and life satisfaction ( p = .006). Conclusions Online recruitment yielded a more geographically diverse but less sociodemographically diverse sample of AYAs who were farther from diagnosis and had poorer psychosocial wellbeing than in-person recruitment at an urban hospital. Future research efforts should consider partnering with under-represented communities and using targeted and stratified online and in-person recruitment strategies to achieve an inclusive and representative sample of AYAs.
Using the ABC theory of emotion to examine the relationship between health anxiety and health information-seeking behavior among the rural population
Authors: Gong Hongcun , Deng Sanhong , Wang Hao , Cao Gaohui 
Published: October 2023

Objective The aim of the current study was to explore the relationship between online and offline health information-seeking behaviors, as antecedents and consequences, and health anxiety and related belief factors in rural residents. Methods Based on the ABC theory of emotions (ABC model), this study developed two theoretical models of the association between health anxiety and health information-seeking behavior: Placing health information-seeking behavior (both online and offline) as an outcome and antecedent, respectively, and setting three belief factors of the perceived health threat, intolerance of uncertainty, and catastrophic misinterpretations. We collected 730 self-reported data points from 20 June to 5 July 2022 for rural residents in China and empirically tested the research model and hypotheses using partial least squares-based structural equation modeling. Results The perceived health threat and intolerance of uncertainty are significant motivators of health anxiety, and health anxiety has a direct beneficial effect on both online and offline health information-seeking behaviors. Health anxiety is influenced either directly or indirectly by catastrophic misinterpretations resulting from online health information-seeking, while offline health information-seeking behavior does not contribute as strongly to health anxiety directly but mainly reinforces it through the mediating influence of catastrophic misinterpretations. Conclusions Rural residents’ health anxiety promotes their online and offline health information behaviors. And both their online and offline health information-seeking behaviors may promote health anxiety directly and through catastrophic misinterpretations. Comparing the two, online health information-seeking behaviors primarily exacerbate health anxiety through direct effects, whereas offline health information-seeking behaviors primarily affect health anxiety through catastrophic misinterpretations. We provide suggested guidelines for alleviating health anxiety and regulating health information behaviors among rural residents.
Women’s knowledge, perception, practice, and experience of using of skin-lightening products in the United Arab Emirates (UAE): A cross-sectional survey
Authors: Beshir Semira , Shamseldin Al Gailani Ali Eiman , Ramadan Doaa , Bassam Ghina , Maher Esraa , Ismail Samar , Hamdi Hebatallah 
Published: October 2023

Background: Skin lightening products (SLPs) are popular among women for medical and non-medical reasons. Therefore, this study aimed to determine the extent of SLP use among women, identify their sources of information, explore factors associated with SLP use and SLP related knowledge, attitudes, and practices (KAP) among women in the UAE. Methods: A structured questionnaire in English and Arabic was distributed to women in the UAE. The questionnaire included demographic characteristics, knowledge (10 items), attitudes (10 items), practices (9 items), and four additional questions on SLP use. Adequate KAP scores were defined as a score of ≥70% out of the maximum score for each KAP section. Chi-square tests were used to test associations between demographic characteristics, dichotomized KAP scores, and SLP use. Results: The study included 370 participants, 50% of the respondents were aged 18–24, and 40% were from the Middle East, 64.8% were unmarried, 91% had university degrees, and 50% had healthcare related profession. Among the respondents 25% use SLPs, the majority use SLPs for non-medical reasons. Employment status is significantly associated with SLP use. The percentage of participants with a knowledge, attitude, and practice score of ≥70% is 66.48%, 76.75%, and 74.72% respectively. Type of profession was significantly associated knowledge and practice. In addition, nationality was also associated with practice. Conclusion: This study highlighted knowledge, attitude and practice gaps and varied levels of SLP-related KAP among women in the UAE. To promote the rational use of SLPs, educational campaigns and stricter regulations are necessary.
Kinematic and Kinetic Comparisons of Arm Slot Position Between High School and Professional Pitchers
Authors: Manzi Joseph E. , Ruzbarsky Joseph J. , Krichevsky Spencer , Sudah Suleiman Y. , Estrada Jennifer , Wang Zhaorui , Moran Jay , Kunze Kyle N. , Ciccotti Michael C. , Chen Frank R. , Dines Joshua S. 
Published: October 2023

Background: Throwing arm kinetics differ in pitchers at varying arm slot (AS) positions (frontal-plane arm position at ball release relative to the vertical axis). Purpose: To determine how kinematic and kinetic values differ between professional and high school pitchers with varying AS positions, and whether these differences are similarly observed in both populations. Methods: High school (n = 130) and professional (n = 288) pitchers threw 8 to 12 fastballs under 3-dimensional motion capture technology. Pitchers in each cohort were subdivided based on mean AS position at ball release: AS1 (least degree of AS: most overhand throwing styles), AS2 (intermediate degree of AS: three-quarter throwing styles), or AS3 (greatest degree of AS: most sidearm throwing styles). Kinetic and kinematic parameters were compared between groups. Study Design: Controlled laboratory study. Results: High school pitchers had a more overhand AS at ball release (50° ± 11°) compared with professional pitchers (58° ± 14°) ( P < .001). In both cohorts, AS1 pitchers had significantly greater shoulder abduction (high school, P <0.001; professional, P <0.0001) and lateral trunk flexion (high school, P < 0.001; professional, P <0.0001) at ball release compared with AS3 pitchers. Professional pitchers with an AS3 position had significantly delayed timing of maximum upper trunk angular velocity compared with AS1 pitchers (64% ± 7% vs 57% ± 7% of pitch time, respectively; P < .0001). A significant positive correlation between AS and elbow flexion torque was found in high school pitchers ( P = .002; β = 0.28), and a significant negative correlation between AS and elbow varus torque ( P < .001; β = –0.22) and shoulder internal rotation torque ( P < .001; β = –0.20) was noted in professional pitchers. Conclusion: AS position was related to shoulder abduction and trunk lateral tilt. Professional and high school pitchers with varying AS positions did not experience similar changes in throwing arm kinetics. Clinical Relevance: In professional pitchers, the earlier onset of maximum upper trunk angular velocity with overhand throwing style may reflect inappropriate pelvis-trunk timing separation, a parameter implicated in upper extremity injury, and the negative correlation between AS and elbow varus and shoulder internal rotation torque suggests that both excessive and minimal AS positions have negative implications.
The effect of alloying element on the thermophysical properties of carbon fiber-graphite flakes/copper composites
Authors: Chen Youming , Liu Tongle , Miao Guodong , Huang Junchen , Yang Bing , Liu Qian 
Published: October 2023

In this study, carbon fiber-graphite flake/copper composites were prepared by powder metallurgy. The impact of the alloying elements Ti and Zr on the composites’ properties was investigated, and the influence of varying Zr contents on the phase structure and thermal conductivity of the composites was also explored. The results indicate that composites containing Zr exhibit better flexural strength and thermal conductivity compared to those containing Ti. When the volume fraction of carbon fiber is 2% and 2 wt% Zr is added to copper matrix, the carbide layer at the composite interface is uniform and has a thickness of 0.36 μm. The thermal conductivity of the composite material is up to 597.5 W/(m∙K). The mechanical properties of the composites are enhanced by the synergistic effect of adding carbon fiber and alloying matrix and the composite shows a remarkable flexural strength of 150.5 MPa, which is 58.3% higher compared to composites without carbon fiber. Furthermore, the strengthening mechanism of carbon fiber on the mechanical properties of the composites was examined. The thermal conductivity of the multiphase composites was effectively predicted using the Acoustic Mismatch Model (AMM) combined with the MF module of Digimat software, and the impact of Ti or Zr elements on the composites’ thermal conductivity was analyzed.
Remotely Delivered Psychologically Informed Mindful Movement Physical Therapy for Pain Care: A Framework for Operationalization
Authors: Sullivan Marlysa B. , Hill Kelsea , Ballengee Lindsay A. , Knoblach Daniel , Fowler Christopher , Haun Jolie , Saenger Michael 
Published: October 2023

Background While there is recognition by the greater medical community and physical therapists to address the biopsychosocial needs of people with chronic, persistent pain, there are challenges in implementation and delivery including wide variability in interventions, lack of clear rationale, and absence of clinical models that are feasible and acceptable on a large scale. Important components for psychologically informed physical therapy (PiPT) for pain care include behavioral approaches (e.g., Acceptance and Commitment Therapy), mindfulness, pain neuroscience education, motivational interviewing (MI), and interoceptive skills-building. The Empower Veterans Program (EVP) Mindful Movement framework blends these components and emphasizes a mindfulness and self-compassion approach with MI and body-based experiential learning. This program was offered in-person at the Atlanta and Maryland VA Health Care Centers with published positive Patient Reported Outcomes (PRO) pre-COVID 19 crisis and shifted to entirely remote delivery in March 2020. Objective This paper offers an evidence-based and theory driven framework to operationalize a remotely delivered group-based psychologically informed mindful movement physical therapy intervention as part of an interdisciplinary pain care program. Methods Since 2021 PRO and demographics are collected using a survey administered through Qualtrics over a 12-month period at baseline, immediately post TelePain EVP, at 6 months, and at 12 months, with findings forthcoming. Discussion/Results Tele-pain EVP offers 6-9 groups a week with 7-9 veterans from Atlanta based team and 3-4 groups a week with 5-9 veterans from Maryland based team. Adaptations for remote delivery optimized mindfulness and active learning strategies including interoceptive skills-building and use of MI to support self-efficacy to trust, restore a sense of safety in the body, and explore adaptations for safe movement. Conclusion TelePain-EVP Mindful Movement provides a framework for other programs to translate for their populations and systems to further develop best practices in PiPT for pain care and integration into interdisciplinary care.
Phase 2 study of inotuzumab ozogamicin for measurable residual disease in acute lymphoblastic leukemia in remission
Authors: Jabbour Elias , Haddad Fadi G. , Short Nicholas J. , Senapati Jayastu , Jain Nitin , Sasaki Koji , Jorgensen Jeffrey , Wang Sa A. , Alvarado Yesid , Wang Xuemei , DiNardo Courtney , Masarova Lucia , Kadia Tapan , Garris Rebecca S. , Ravandi Farhad , Kantarjian Hagop 
Published: October 2023

Abstract
The detection of measurable residual disease (MRD) is the strongest predictor of relapse in acute lymphoblastic leukemia (ALL). Using inotuzumab ozogamicin in the setting of MRD may improve outcomes. Patients with ALL in first complete remission (CR1) or beyond (CR2+) with MRD ≥ 1 × 10−4 were enrolled in this phase 2 trial. Inotuzumab was administered at 0.6 mg/m2 on day 1 and 0.3 mg/m2 on day 8 of cycle 1, then at 0.3 mg/m2 on days 1 and 8 of cycles 2-6. Twenty-six consecutive patients with a median age of 46 years (range, 19-70 years) were treated. Nineteen (73%) were in CR1 and seven (27%) in CR2+; 16 (62%) had Philadelphia chromosome–positive ALL. Fifteen (58%) had baseline MRD ≥ 1 × 10−3. A median of 3 cycles (range, 1-6) were administered. Eighteen (69%) patients responded and achieved MRD negativity. After a median follow-up of 24 months (range, 9-43), the 2-year relapse-free survival rate was 54% and the 2-year overall survival rate was 60% in the entire cohort. Most adverse events were low grade; sinusoidal obstruction syndrome was noted in 2 patients (8%). In summary, inotuzumab ozogamicin resulted in favorable survival, MRD negativity rates, and safety profiles for patients with ALL and MRD-positive status. This study was registered at www.ClinicalTrials.gov as #NCT03441061.