bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endometrial Cancer Risk Among Germline BRCA1/2 Pathogenic Variant Carriers: Review of Our Current Understanding and Next Steps
Authors: Sorouri Kimia , Lynce Filipa , Feltmate Colleen M. , Davis Michelle R. , Muto Michael G. , Konstantinopoulos Panagiotis A. , Stover Elizabeth H. , Kurian Allison W. , Hill Sarah J. , Partridge Ann H. , Tolaney Sara M. , Garber Judy E. , Bychkovsky Brittany L. 
Published: December 2023

PURPOSE To review the literature exploring endometrial cancer (EC) risk among surgical candidates with germline BRCA1/2 pathogenic variants (PVs) to guide decisions around risk-reducing (rr) hysterectomy in this population. DESIGN A comprehensive review was conducted of the current literature that influences clinical practice and informs expert consensus. We present our understanding of EC risk among BRCA1/2 PV carriers, the risk-modifying factors specific to this patient population, and the available research technology that may guide clinical practice in the future. Limitations of the existing literature are outlined. RESULTS Patients with BRCA1/2 PVs, those with a personal history of tamoxifen use, those who desire long-term hormone replacement therapy, and/or have an elevated BMI are at higher risk of EC, primarily endometrioid EC and/or uterine papillary serous carcinoma, and may benefit from rr-hysterectomy. Although prescriptive clinical guidelines specific to BRCA1/2 PV carriers could inform decisions around rr-hysterectomy, limitations of the current literature prevent more definitive guidance at this time. A large population-based study of a contemporary cohort of BRCA1/2 PV carriers with lifetime follow-up compared with cancer-gene negative controls would advance this topic and facilitate care decisions. CONCLUSION This review validates a potential role for rr-hysterectomy to address EC risk among surgical candidates with BRCA1/2 PVs. Evidence-based clinical guidelines for rr-hysterectomy in BRCA1/2 PV carriers are essential to ensure equitable access to this preventive measure, supporting insurance coverage for patients with either BRCA1 or BRCA2 PVs to pursue rr-hysterectomy. Overall, this review highlights the complexity of EC risk in BRCA1/2 PV carriers and offers a comprehensive framework to shared decision making to inform rr-hysterectomy for BRCA1/2 PV carriers.
The golden mussel Limnoperna fortunei (Dunker, 1857) as an emerging concern for biodiversity in the Brazilian Cerrado
Authors: Fleury Fernandes De Oliveira Paulo Roberto , Rodrigues Cândido Carvalho , Grano-Maldonado Mayra Ixchel , Lopes Rocha Thiago 
Published: December 2023

The Cerrado biome is an international biodiversity hotspot, but knowledge about the distribution and impact of invasive bivalve species in the rivers of the Central Brazilian Cerrado is scarce. Accordingly, the aim of this study was to extend our knowledge of the geographical distribution of the golden mussel (Limnoperna fortunei) and enlarge the list of the invasive species that have arrived in the Cerrado environment. In this context, invasive mussels may affect native species, but there is little information on their environmental interaction. The study area was the low-middle Paranaíba River, located in and around the hydroelectric power plant of Cachoeira Dourada. In total, 386 specimens were captured and measured, and the reproductive status was defined through a histological approach. Results showed that the mussel shell length varied from 3.8 to 35.5 mm (215.73 ± 5.53 mm); width, from 1.9 to 14.1 mm (7.20 ± 2.24 mm); and height, from 1.4 to 11.8 mm (5.84 ± 2.00 mm). Hence, the populations discovered is likely to be in its third year, and the histological assessment showed that the mussels are reproducing actively. Results indicated that the process of invasion was enhanced by human activities, such as fish farming, considering that the golden mussel is an emerging bio-infestation concern, and it should be considered a serious threat to native species on the Brazilian Cerrado ecosystem. Further studies on cohabitation and interaction with native species are needed.
IMAGE OF THE ORGANIZATION AS AN ELEMENT OF ORGANIZATIONAL CULTURE
Authors: Skripnichenko L. 
Published: December 2023

The purpose of the study was to identify the predominant type of culture in the company, the image profile of the enterprise in the eyes of employees, the level and type of loyalty of personnel. The following research methods were applied in the work: a survey of the staff of a medical institution using the OCAI (Organizational Culture Analyze Instrument) methodology by Kim Cameron and Robert Quinn; a survey using the methodology of A. Ya. Kibanov to study the image profile of the employer; polling on the John Meyer and Natalie Allen organizational loyalty scale; Survey based on the methodology for assessing the level and parameters of the employee’s demonstrated loyalty to the organization. The analysis made it possible to determine what should be paid attention to when carrying out measures to improve and develop the image as an element of organizational culture. Attention was paid to strengthening and improving the organizational culture itself, increasing the loyalty of personnel, as well as improving the poorly developed qualities of the enterprise. The proposed recommendations can be used by the company’s management to strengthen its competitiveness and increase the loyalty of personnel.
MODERN MEANS OF VISUALIZATION OF EDUCATIONAL CONTENT
Authors: Svistunov V. , Mozgovoy A. , Lobachyev V. , Golyshkova I. 
Published: December 2023

The article reveals the problems of organizing the educational process based on the application of one of the most important principles of didactics — visualization (visual presentation of the material). The potential of practical application of this principle in the education system is most clearly reflected in the quality of training and skills development of students. The paper classifies and analyzes various types of visualization used in the educational process. The authors noted the main psychological and pedagogical features and formulated practical recommendations on the use of visual aids and teaching methods on the example of such important integrative subjects as social studies and economics. This research is of scientific and practical value for the training of future teachers in pedagogical universities of Russia, as well as for beginning teachers of higher and additional education, specializing in teaching subjects from the cycle of socio-economic disciplines.
RELEVANCE OF THE LEADERSHIP OF AN HR SPECIALIST IN RUSSIAN COMPANIES
Authors: Lebedeva N. , Chelnokova O. 
Published: December 2023

The article presents an analysis of the approaches of domestic and foreign authors to the problems of leadership in the organization and their relation to the request for the leadership of an HR specialist. Leadership is considered as a mandatory element of management that determines both the management style in the company as a whole and the specifics of the work of an HR specialist in particular. The study reveals the specificity of the influence of an HR specialist on the corporate culture and staff loyalty in connection with the request for a leadership from the management. It has been established that the most popular leadership style of an HR specialist is an advisory style, in which goals and methods to achieve them are discussed, but the final decision on both goals and methods is made by the head. The authors analyzed the relationship between the leadership of an HR specialist and the relevance of the tools used in the activities of HR services. Based on the results obtained, recommendations were formed to identify the need for HR leadership and to build efficient interaction between managers and HR specialists.
The economic burden of stomas in the UK: a retrospective observational study of health records and hospital encounters
Authors: Mthombeni Fiona , Cawson Matthew , Chan Gerald , Boisen Esben Bo , Rethmeier Line O. , Pearson-Stuttard Jonathan 
Published: December 2023

Background: Stomas divert waste from the small intestine (ileostomy), large intestine (colostomy) or ureters (urostomy), and complications are common. Aims: This study evaluated healthcare resource utilisation (HCRU) and costs of stomas from a UK perspective. Methods: This was a retrospective observational study of adults with new stomas (New Stoma Group) or new/existing stomas and >6 months of follow-up (Established Stoma Group) using health records linked with hospital encounters (January 2009–December 2018). Age- and sex-matched controls were identified for each stoma case (1:50) Findings: Both the New (n=8533) and Established (n=9397) stoma groups had significantly higher HCRU (all P<0.0001) and associated costs (all P<0.01), driven by inpatient admissions. New Stoma Group: colostomy versus controls, £3227 versus £99 per person; ileostomy, £2576 versus £78 per person; and urostomy, £2850 versus £110 per person (all P<0.0001). Findings were similar in the Established Stoma Group. Conclusion: Stomas are associated with a substantial economic burden in the UK driven by hospital care. (Supplementary data tables can be obtained from the authors.)
Mycobacterium ulcerans-Bordetella trematum chronic tropical cutaneous ulcer: A four-case series, Côte d’Ivoire
Authors: Tchan Bi Goré Oscar , Kakou-Ngazoa Solange , Dizoe Sylveste , Hammoudi Nassim , Grine Ghiles , Ruimy Raymond , Drancourt Michel 
Published: December 2023

Background
Chronic tropical cutaneous ulcers remain a neglected medical condition in West Africa, particularly Buruli ulcer, which is caused by mycolactone cytotoxin-secreting Mycobacterium ulcerans (M. ulcerans). Medical management of this highly debilitating and necrotising skin infection may be modified by colonisation and co-infection of the ulcer by opportunistic and pathogenic microorganisms, which considerably delays and increases the cost of treatment.

Methodology/principal finding
We diagnosed chronic tropical cutaneous ulcers in nine patients in Côte d’Ivoire using M. ulcerans-specific PCRs and culturomics. This revealed M. ulcerans in 7/9 ulcer swabs and 5/9 control swabs as well as an additional 122 bacterial species, 32 of which were specific to ulcers, 61 specifics to the controls, and 29 which were shared, adding 40 bacterial species to those previously reported. Whole genome sequencing of four Bordetella trematum (B. trematum) isolates in four Buruli ulcer swabs and no controls indicated cytolethal distending toxins, as confirmed by cytotoxic assay.

Conclusions/significance
In four cases of Buruli ulcer in Côte d’Ivoire, B. trematum was a co-pathogen which was resistant to rifampicin and clarithromycin, unmatching M. ulcerans antibiotic susceptibility profile and counteracting the current treatment of Buruli ulcer in West Africa and Australia. Thus, we report here chronic mixed M. ulcerans-B. trematum chronic tropical ulcer as a specific form of Buruli ulcer in West Africa.
Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review
Authors: Joshi Mahima , Muneer Javed , Mbuagbaw Lawrence , Goswami Ipsita 
Published: December 2023

Background
Therapeutic hypothermia (TH) is a widely practiced neuroprotective strategy for neonates with hypoxic-ischemic encephalopathy. Induced hypothermia is associated with shivering, cold pain, agitation, and distress.

Objective
This scoping review determines the breadth of research undertaken for pain and stress management in neonates undergoing hypothermia therapy, the pharmacokinetics of analgesic and sedative medications during hypothermia and the effect of such medication on short- and long-term neurological outcomes.

Methods
We searched the following online databases namely, (i) MEDLINE, (ii) Web of Science, (iii) Cochrane Library, (iv) Scopus, (v) CINAHL, and (vi) EMBASE to identify published original articles between January 2005 and December 2022. We included only English full-text articles on neonates treated with TH and reported the sedation/analgesia strategy used. We excluded articles that reported TH on transport or extracorporeal membrane oxygenation, did not report the intervention strategies for sedation/analgesia, and reported hypoxic-ischemic encephalopathy in which hypothermia was not applied.

Results
The eligible publications (n = 97) included cohort studies (n = 72), non-randomized experimental studies (n = 2), pharmacokinetic studies (n = 4), dose escalation feasibility trial (n = 1), cross-sectional surveys (n = 5), and randomized control trials (n = 13). Neonatal Pain, Agitation, and Sedation Scale (NPASS) is the most frequently used pain assessment tool in this cohort. The most frequently used pharmacological agents are opioids (Morphine, Fentanyl), benzodiazepine (Midazolam) and Alpha2 agonists (Dexmedetomidine). The proportion of neonates receiving routine sedation-analgesia during TH is center-specific and varies from 40–100% worldwide. TH alters most drugs’ metabolic rate and clearance, except for Midazolam. Dexmedetomidine has additional benefits of thermal tolerance, neuroprotection, faster recovery, and less likelihood of seizures. There is a wide inter-individual variability in serum drug levels due to the impact of temperature, end-organ dysfunction, postnatal age, and body weight on drug metabolism.

Conclusions
No multidimensional pain scale has been tested for reliability and construct validity in hypothermic encephalopathic neonates. There is an increasing trend towards using routine sedation/analgesia during TH worldwide. Wide variability in the type of medication used, administration (bolus versus infusion), and dose ranges used emphasizes the urgent need for standardized practice recommendations and guidelines. There is insufficient data on the long-term neurological outcomes of exposure to these medications, adjusted for underlying brain injury and severity of encephalopathy. Future studies will need to develop framework tools to enable precise control of sedation/analgesia drug exposure customized to individual patient needs.
The potential of piR-823 as a diagnostic biomarker in oncology: A systematic review
Authors: Sohn Eun Jung , Han Myoung-Eun , Park Young Mok , Kim Yun Hak , Oh Sae-Ock 
Published: December 2023

Background
Emerging evidence has demonstrated that PIWI-interacting RNAs (piRNAs) play important roles in various physiological processes and contribute to cancer progression. Moreover, piRNAs and PIWI protein levels are associated with the prognosis and chemoresistance of various cancers. The limitations of biomarkers challenge early detection and monitoring of chemoresistance and cancer relapse.

Methods
To evaluate the potential of piRNA as a diagnostic biomarker in oncology, we systematically reviewed previous studies on the subject. PubMed, Embase, and Cochrane databases were searched to evaluate the diagnostic relevance of piRNAs in cancer. Eighteen studies (2,352 patients) were included. The quality of each study was evaluated with AMSTAR and QUADAS-2 tool.

Results & conclusions
The area under the curve (AUC) values of 26 piRNAs in patients with cancer ranged from 0.624 to 0.978, with piR-9491 showing the highest value (0.978). The sensitivity of the total of 21 piRNAs in cancer patients was between 42.86 and 100, with piR-9491 showing the highest sensitivity (100). The specificity of these 21 piRNAs ranged from 60.10 to 96.67 (with piR-018569 showing the highest specificity (96.67)). Their odds ratios were between 1.61 and 44.67, and piR-12488 showed the highest odds ratio (44.67). Generally, the piRNAs in this review showed better sensitivity and AUC values than current clinical diagnostic biomarkers, although current biomarkers appear to be more specific. Reviewed piRNAs showed better diagnostic performance than currently used clinical biomarkers. Notably, piR-823 showed a significant diagnostic performance in four types of cancer (colorectal, esophageal, gastric, and renal cell cancer). However, all 18 studies included in this review were a case-control study. So, further prospective studies are required for their validation.
Productivity-adjusted life-years and correlates of uncontrolled hypertension at two health facilities in Zambia
Authors: Povia Joreen P. , Masenga Sepiso K. , Hamooya Benson M. , Gebremeskel Yordanos 
Published: December 2023

Background
Hypertension has in the recent past surfaced as one of the conditions that has a significant impact on workforce productivity in emerging economies. Zambia is no different and has in the recent past recorded increasing cases. Despite the impact of hypertension being of great importance in regards to productivity, we have scarcity of data and studies on hypertension-related Productivity-Adjusted Life-Years (PALYs) in Zambia and Africa at large.
This study assessed the impact of hypertension on PALYs lost and socioeconomic factors associated with nonadherence to antihypertensive medication (NATAM).

Methods
This was a cross-sectional study of 198 participants from Livingstone University Teaching Hospital and Maramba Clinic situated in Livingstone, Zambia. Structured questionnaires were used to collect data. Productivity index multiplied by years lived was used to calculate PALYs and descriptive statistics were used to summarize sociodemographic, clinical and economic variables. Multivariable logistic regression was used to determine factors associated with NATAM.

Results
The participants had a median age (interquartile range (IQR)) of 49 years (41, 59) and 60.1% (n = 119) were females while 39.9% (n = 79) were male. Our estimated PALYs lost per person due to hypertension were 0.2 (IQR 0.0, 2.7). Cumulative PALYs value lost due to the burden of hypertension was estimated to be at $871,239.58 in gross domestic product (GDP). The prevalence of NATAM was 48% (n = 95). The factors that were significantly associated with NATAM were age (odds ratio (OR) 0.94; 95% confidence interval (CI) 0.90, 0.98), female sex (OR 2.52; 95%CI 1.18, 5.40), self-employment (OR 2.57; 95%CI 1.02, 6.45) and absenteeism from work (OR 3.60; 95%CI 1.16, 11.22).

Conclusions
Findings in our study highlight a high economic loss of PALYs due to hypertension with a potential to impact GDP negatively. We also found that NATAM reduced productivity and income among individuals of working age further impacting PALYs lost due to hypertension. The factors associated with NATAM were age, sex, employment status and absenteeism from work. This study underscores the need for interventions targeting young people, females, self-employed individuals, and absentees at work to improve adherence to antihypertensive drugs in order to reduce PALYs lost due to hypertension.
Cardiac response to water activities in children with Long QT syndrome type 1
Authors: Lundström Anna , Wiklund Urban , Winbo Annika , Eliasson Håkan , Karlsson Marcus , Rydberg Annika 
Published: December 2023

Background
Swimming is a genotype-specific trigger in long QT syndrome type 1 (LQT1).

Objective
To examine the autonomic response to water activities in children and adolescents with LQT1.

Methods
In this cross-sectional study, LQT1 patients were age and sex matched to one healthy control subject. Electrocardiograms (ECGs) were recorded during face immersion (FI), swimming, diving, and whole-body submersion (WBS). Heart rate (HR) and heart rate variability (HRV) was measured. The high frequency (HF) component of HRV was interpreted to reflect parasympathetic activity, while the low frequency (LF) component was interpreted as reflecting the combined influence of sympathetic and parasympathetic activity on autonomic nervous modulation of the heart.

Results
Fifteen LQT1 patients (aged 7–19 years, all on beta-blocker therapy) and fifteen age and sex matched non-medicated controls were included. No significant ventricular arrhythmias were observed in the LQT1 population during the water activities. Out of these 15 matched pairs, 12 pairs managed to complete FI and WBS for more than 10 seconds and were subsequently included in HR and HRV analyses. In response to FI, the LQT1 group experienced a drop in HR of 48 bpm, compared to 67 bpm in the control group (p = 0.006). In response to WBS, HR decreased by 48 bpm in the LQT1 group and 70 bpm in the control group (p = 0.007). A significantly lower PTOT (p < 0.001) and HF (p = 0.011) component was observed before, during and after FI in LQT1 patients compared with the controls. Before, during and after WBS, a significantly lower total power (p < 0.001), LF (p = 0.002) and HF (p = 0.006) component was observed in the LQT1 patients.

Conclusion
A significantly lower HR decrease in response to water activities was observed in LQT1 subjects on beta-blocker therapy, compared to matched non-medicated controls. The data suggests an impaired parasympathetic response in LQT1 children and adolescents. An aberrant autonomic nervous system (ANS) response may cause an autonomic imbalance in this patient group.
Ljudlitteratur med buller och bång
Authors: Steiner Ann 
Published: December 2023

Audio Fiction Making Noise: A Changing Genre in Children’s Literature
This article is a study of contemporary audio fiction for children in Sweden, what is sometimes also called audio originals or born-audio books. Audio fiction is defined in the article as literature written to be recorded for audio and consumed through listening. It is a genre related to, and overlapping with, audiobooks, radio, and podcasts but obviously also with literature in printed books. While audio fiction has risen in production and popularity it is not a new phenomenon as such, but rather a kind of literature that has developed over time. The article gives historical examples of children’s audio fiction and situates the contemporary production in a larger context of a changing media world and the book market for children’s literature. The main examples used to understand the phenomenon are IJustWantToBeCool’s Sommarjobbarna (The Summer Workers, 2020­–2022) and Camilla Brinck’s series on the mice Musse & Helium (2017–). These are the most popular audiobooks for children in the last years and both series as well as authors are linked to other media such as Youtube, podcast, print, and music. The theoretical conjectures derive from book history and sociology of literature, arguing that changing media for literature has direct implications for literary form, function, and dissemination. Methodologically the article is a genre study using Alastair Fowler’s concept of genre as aggregated features. Thus, a comparison is made between the two examples and other formats such as children’s print books, audiobooks, and radio drama as well as literary genres such as adventure fiction, melodrama, and slapstick. Furthermore, narrative aspects of the two audio literature examples are analyzed in terms of metafiction, voice, and sound effects.