bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipidome of mammographic breast density in premenopausal women
Authors: Getz Kayla R. , Jeon Myung Sik , Luo Chongliang , Luo Jingqin , Toriola Adetunji T. 
Published: October 2023

Abstract
Background
High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD are unclear. Lipids play important roles in cell differentiation, and perturbations in lipid metabolism are implicated in cancer development. Nevertheless, no study has applied untargeted lipidomics to profile the lipidome of MBD. Through this study, our goal is to characterize the lipidome of MBD in premenopausal women.

Methods
Premenopausal women were recruited during their annual screening mammogram at the Washington University School of Medicine in St. Louis, MO. Untargeted lipidomic profiling for 982 lipid species was performed at Metabolon (Durham, NC®), and volumetric measures of MBD (volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV)) was assessed using Volpara 1.5 (Volpara Health®). We performed multivariable linear regression models to investigate the associations of lipid species with MBD and calculated the covariate-adjusted least square mean of MBD by quartiles of lipid species. MBD measures were log10 transformed, and lipid species were standardized. Linear coefficients of MBD were back-transformed and considered significant if the Bonferroni corrected p-value was < 0.05.

Results
Of the 705 premenopausal women, 72% were non-Hispanic white, and 23% were non-Hispanic black. Mean age, and BMI were 46 years and 30 kg/m2, respectively. Fifty-six lipid species were significantly associated with VPD (52 inversely and 4 positively). The lipid species with positive associations were phosphatidylcholine (PC)(18:1/18:1), lysophosphatidylcholine (LPC)(18:1), lactosylceramide (LCER)(14:0), and phosphatidylinositol (PI)(18:1/18:1). VPD increased across quartiles of PI(18:1/18:1): (Q1 = 7.5%, Q2 = 7.7%, Q3 = 8.4%, Q4 = 9.4%, Bonferroni p-trend = 0.02). The lipid species that were inversely associated with VPD were mostly from the triacylglycerol (N = 43) and diacylglycerol (N = 7) sub-pathways. Lipid species explained some of the variation in VPD. The inclusion of lipid species increased the adjusted R2 from 0.45, for a model that includes known determinants of VPD, to 0.59.

Conclusions
We report novel lipid species that are associated with MBD in premenopausal women. Studies are needed to validate our results and the translational potential.
A web-based educational therapy intervention associated with physical exercise to promote health in fibromyalgia in Brazil: the Amigos De Fibro (Fibro Friends) study protocol
Authors: Antunes Mateus Dias , da Rocha Loures Felipe Cayres Nogueira , de Souza Ingred Merllin Batista , Cruz Ariela Torres , de Oliveira Januário Priscila , Pinheiro Mara Maria Lisboa Santana , Schmitt Ana Carolina Basso , Frutos-Bernal Elisa , Martín-Nogueras Ana María , Marques Amélia Pasqual 
Published: October 2023

Abstract
Background
Health education is one of the main items to enable health promotion to patients with fibromyalgia. The objective of the study “Amigos de Fibro (Fibro Friends)” is to evaluate the impact of an educational intervention associated with physical exercise based on the web in promoting health and quality of life of patients with fibromyalgia in Brazil.

Methods
A study with a randomized controlled trial approach will be carried out. The sample will consist of 24 participants, divided into two groups, with 12 individuals each. The experimental group will participate in meetings with lectures, debates, conversation rounds and exercises by a multidisciplinary team. Physical exercises will also be performed in an online environment. On the other hand, the control group will receive an e-book of education and self-care. Primary outcomes will be quality of life. The secondary outcomes will be sociodemographic and health profile, pain intensity, sleep quality, self-care agency, usage and costs of health and social care services, viability of the program and program participation. In addition, a qualitative evaluation process will be carried out with the participants. After the intervention, the data of both groups will be collected again, as well as after 3, 6, and 12 months to verify the effect and the maintenance of the intervention.

Discussion
The results will provide data for studies to consider the use of this tool in the future by professionals working in the field of rheumatology.

Trial registration
The protocol was registered in the Brazilian Registry of Clinical Trials RBR-3rh759 (https://trialsearch.who.int/Trial2.aspx?TrialID=RBR-3rh759). Date of registration: 07/02/2020].
Translating medical device innovations to market - a Ugandan perspective
Authors: Matovu Brian , Baluka Jackline Winfred , Takuwa Mercy , Namuli Lucy Kevin , Mpaata Charles Norman , Mugaga Julius , Mulindwa Benedict , Nalwoga Racheal , Wolters Maria K , Ssekitoleko Robert Tamale 
Published: October 2023

AbstractThere is a disparity between low and middle-income countries (LMICs) and high-income countries (HICs) in translating medical device innovations to the market, affecting health care service delivery. Whereas medical technologies developed in HICs face substantial challenges in getting to the bedside, there are at least clear pathways in most of the major markets, such as the UK, the EU, and the USA. Much less is known about the challenges that innovators of medical technologies face in LMICs. The aim of this study was to map out current bottlenecks in medical device innovation in Uganda, a LMIC in Sub-Saharan East Africa.A cross-sectional survey was carried out using a digital questionnaire. Twenty-one individuals completed the questionnaire, with the majority being medical device innovators (n = 12). Only one of these had undertaken all the innovation stages, up to clinical validation. Very few innovators had established companies, and/or acquired intellectual property. It is evident from similar studies that challenges in medical device translations are multidimensional, and hence interdisciplinary collaborations are key to accelerating translation processes, especially for LMICs.
Localized amyloidosis of the ureter: a case report
Authors: Aoki Shuntaro , Kawahara Takashi , Tajirika Hironao , Yasui Masato , Terao Hideyuki , Funahashi Makoto , Makiyama Kazuhide , Uemura Hiroji , Hayashi Hiroyuki , Ohta Junichi 
Published: October 2023

Abstract
Background
Amyloidosis is a collection of disorders characterized by the extracellular deposition of amyloid, a specialized fibrous protein, in diverse tissues, leading to functional impairments.

Case presentation
A 70-year old Asian-Japanese female was referred to our department for further examination of her left hydronephrosis come from lower ureteral obstruction. Contrast enhanced CT and retrograde pyelo-nephrography revealed left ureteral tumor. Though ureteroscropic biopsy did not show malignant pathological findings, ureteroscopic image suspected malignant disease, thus nephroureterectomy was performed. Pathological findings revealed localized ureteral amyloidosis. Whole body examination including gastro endoscopy and cardio ultrasonography could not reveal amyloidosis except ureter. She was free from recurrence 9 months postoperatively.

Conclusion
We herein report a rare case of localized ureteral amyloidosis.
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Authors: Wei Ying , Liu Jia , Wang Guang , Wang Ying 
Published: October 2023

Abstract
Background
Adipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). The study aimed to evaluate sex differences in the association between Adipo-IR and NAFLD, and further investigated other potential modifiers.

Methods
This cross-sectional study enrolled adults without diabetes who underwent physical examinations in Beijing Chao-Yang Hospital. We calculated the Adipo-IR index as the product of the fasting insulin and free fatty acid concentration. We categorized Adipo-IR into four groups according to quartiles, using the first interquartile range (Q1) as the reference. Logistic regression was used stratified by the modifiers after adjustment for potential confounders.

Results
There were 5586 participants in the study, 49.8% (n = 2781) of whom were women and 30.4% (n = 1698) with NAFLD. There was a graded positive association between Adipo-IR and NAFLD, with sex (P = 0.01) and hyperlipidemia (P = 0.02) modifying this association. In the hyperlipidemic women, for one unit increase in log-Adipo-IR, the odds of having NAFLD increased by 385% after adjustment for potential confounders (OR = 4.85, 95%CI 3.54–6.73, P < 0.001). However, it turned out that the odds of having NAFLD increased by 131% (OR = 2.31, 95%CI 1.74–3.11, P < 0.001), 216% (OR = 3.16, 95%CI 2.56–3.93, P < 0.001), 181% (OR = 2.81, 95%CI 1.88–4.28, P < 0.001) in normolipidemic men, hyperlipidemic men, and normolipidemic women, respectively. Similarly, the ORs for the association between Adipo-IR and NAFLD in women with age ≥ 50 years were higher than ORs in women with age < 50 years.

Conclusions
The positive correlation between Adipo-IR and NAFLD was stronger in hyperlipidemic women, compared with normolipidemic or hyperlipidemic men, or normolipidemic women. The association also strengthened for women over 50 years. Treatment strategies targeting Adipo-IR to alleviate NAFLD may be of value, especially in hyperlipidemic women after menopause.
RETRACTED ARTICLE: Auto scheduling through distributed reinforcement learning in SDN based IoT environment
Authors: Wu Yuanyuan 
Published: October 2023

AbstractThe Internet of Things (IoT), which is built on software-defined networking (SDN), employs a paradigm known as channel reassignment. This paradigm has great potential for enhancing the communication capabilities of the network. The traffic loads may be scheduled more effectively with the help of an SDN controller, which allows for the transaction of matching channels via a single connection. The present techniques of channel reassignment, on the other hand, are plagued by problems with optimisation and cooperative multi-channel reassignment, which affect both traffic and routers. In this paper, we provide a framework for SDN–IoT in the cloud that permits multi-channel reassignment and traffic management simultaneously. The multi-channel reassignment based on traffic management is optimised via the use of a deep reinforcement learning technique, which was developed in this paper. We do an analysis of the performance metrics in order to optimise the throughput while simultaneously reducing the rate of packet loss and the amount of delay in the process. This is achieved by distributing the required traffic loads over the linked channels that make up a single connection.
Prioritization of e-traceability drivers in the agri-food supply chains
Authors: Krstić Mladen , Agnusdei Giulio Paolo , Tadić Snežana , Miglietta Pier Paolo 
Published: October 2023

AbstractElectronic traceability (e-traceability) is a growing trend in the agri-food industry, offering improved transparency, accountability, and reduced risk of foodborne illnesses through the use of electronic systems to trace products throughout the entire supply chain. E-traceability drivers in the agri-food supply chain encompass diverse factors motivating companies to adopt electronic systems for product tracking, aiming to enhance visibility, minimize risk, ensure compliance, and promote safety, sustainability, and efficiency through clear and verifiable records of product origins, quality, and sustainability, building consumer trust and loyalty. By identifying the main drivers of e-traceability, this research aims to shed light on the factors that motivate companies to implement electronic systems for tracking and monitoring products. For solving this problem of multi-criteria decision-making (MCDM), this study proposes a hybrid MCDM model. The model combines “Factor Relationship” (FARE) and “Axial Distance-based Aggregated Measurement” (ADAM) methods in the fuzzy environment. The results indicate that the most important drivers are supply chain efficiency, technology development and sustainability. These drivers are critical and they significantly impact the successful implementation and adoption of e-traceability strategies in the agri-food sector.
Differential diagnosis of unipolar versus bipolar depression by GSK3 levels in peripheral blood: a pilot experimental study
Authors: Rosso Gianluca , Maina Giuseppe , Teobaldi Elena , Balbo Ilaria , Di Salvo Gabriele , Montarolo Francesca , Rizzo Pesci Nicola , Tempia Filippo , Hoxha Eriola 
Published: October 2023

Abstract
Background
The differential diagnosis of patients presenting for the first time with a depressive episode into unipolar disorder versus bipolar disorder is crucial to establish the correct pharmacological therapy (antidepressants vs mood stabilizers), but no biological markers are currently available. Several lines of evidence indicate an involvement of Glycogen Synthase Kinase-3 (GSK3) in the pathophysiology of depression. However, previous reports about GSK3 in peripheral blood were incomplete or inconsistent, so a specific marker is not yet available. The aim was to search for consistent differences in GSK3α and GSK3β or of their phosphorylated forms in samples of peripheral blood from patients with unipolar and bipolar depression.

Methods
Mononucleate peripheral blood cells (PBMCs) of samples from patients presenting with a depressive episode were analyzed with the western blot technique.

Results
The total amount of GSK3β in PBMCs was significantly lower in patients with bipolar disorder than in patients with unipolar depression. The sensitivity based on GSK3β was 85%. GSK3α was not significantly different but allowed a correct detection of 57% of BD patients. The combination in series of GSK3β and GSK3α yields a sensitivity of about 100%, but with 26.7% false negatives.

Conclusions
Our results suggest that PBMC GSK3β could be a candidate biomarker for the differential diagnosis of bipolar disorder versus unipolar depression. This finding may help in implementing the still limited panel of peripheral biomarkers for differential diagnosis between unipolar and bipolar disorder in patients presenting with a depressive episode.
Posterior Interhemispheric Transtentorial Subsplenial Approach for Posterior Thalamic Tumors: 2-Dimensional Operative Video
Authors: Doğruel Yücel , Rahmanov Serdar , Güngör Abuzer , Türe Uğur 
Published: October 2023

INDICATIONS: CORRIDOR AND LIMITS OF EXPOSURE:
The posterior interhemispheric transtentorial subsplenial approach provides a direct corridor to posterior thalamic lesions without a cortical or callosal incision.
1

ANATOMIC ESSENTIALS: NEED FOR PREOPERATIVE PLANNING AND ASSESSMENT:
This corridor is through the posterior interhemispheric fissure along the medial surface of the cuneus and allows the subsplenial region to be explored. Evaluating the tumor's size and extension is crucial to determining the suitability of this approach. The deep venous system may be displaced from mass effect, requiring preoperative venous examination.

ESSENTIALS STEPS OF THE PROCEDURE:
A 34-year-old male patient was admitted elsewhere with blurred vision and imbalance. MRI revealed a right-sided posterior thalamic tumor with heterogeneous contrast enhancement. The patient was followed-up after placement of a ventriculoperitoneal shunt. Seven months later, he was admitted to our clinic because the tumor had grown. The patient underwent surgical intervention. The patient was placed in the prone oblique position. After dural opening, the quadrigeminal cistern was opened to release cerebrospinal fluid, allowing significant gravity relaxation of the ipsilateral hemisphere. The tentorium was cut and retracted to achieve the necessary exposure.

PITFALLS/AVOIDANCE OF COMPLICATIONS:
The most serious complications of this approach occur from vascular injuries. Gravitational retraction of the occipital lobe protects the optic radiation, and anatomic landmarks help the surgeon maintain anatomic orientation.

VARIANTS AND INDICATIONS FOR THEIR USE:
The perimedian supracerebellar transtentorial approach is an alternative to the posterior interhemispheric transtentorial subsplenial approach for lesions in this area; however, the indications and limits of these approaches have some differences.
The patient consented to the procedure and to the publication of his/her image.
Images at 0:29 reused from Serra et al,
1
with permission from Elsevier.
Expression of Wnt5a and ROR2, Components of the Noncanonical Wnt-Signaling Pathway, is Associated with Tumor Differentiation in Hepatocellular Carcinoma
Authors: Wakizaka Kazuki , Kamiyama Toshiya , Kakisaka Tatsuhiko , Orimo Tatsuya , Nagatsu Akihisa , Aiyama Takeshi , Shichi Shunsuke , Taketomi Akinobu 
Published: October 2023

Abstract
Background
Wnt5a is the key ligand of the noncanonical Wnt pathway, and receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor associated with Wnt5a. The association between the noncanonical Wnt-signaling pathway and carcinogenesis in hepatocellular carcinoma (HCC) is unclear. This study investigated the significance of ROR2 expression in HCC.

Methods
The study examined ROR2 expression in liver cancer cell lines. Immunohistochemical staining of ROR2 was performed on 243 resected HCC specimens. The study investigated ROR2 expression and its association with clinicopathologic factors and prognosis.

Results
Findings showed that ROR2 was expressed in well-differentiated Huh7 and HepG2 cells, but not in poorly differentiated HLE and HLF cells. Expression of ROR2 was positive in 147 (60.5%) and negative in 96 (39.5%) HCC specimens. A significant association was shown between ROR2 negativity and high alpha-fetoprotein (AFP) level (P = 0.006), poor differentiation (P = 0.015), and Wnt5a negativity (P = 0.024). The 5-year overall survival (OS) rate for the ROR2-negative group (64.2 %) tended to be worse than for the ROR2-positive group (73.8%), but the difference was not significant (P = 0.312). The 5-year OS rate was 78.7% for the ROR2+Wnt5a+ group, 71.3 % for the ROR2+Wnt5a− group, 80.8% for the ROR2−Wnt5a+ group, and 60.5 % for the ROR2−Wnt5a− group. The OS in the ROR2−Wnt5a− group was significantly poorer than in the ROR2+Wnt5a+ group (P = 0.030). The multivariate analysis showed that Wnt5a−ROR2− was an independent prognostic factor (hazard ratio, 2.058; 95% confidence interval, 1.013–4.180; P = 0.045).

Conclusions
The combination of ROR2 and Wnt5a may be a prognostic indicator for HCC. The Wnt5a/ROR2 signal pathway may be involved in the differentiation of HCC. This pathway may be a new therapeutic target for HCC.
Gemcitabine with Cisplatin Versus Hepatic Arterial Infusion Pump Chemotherapy for Liver-Confined Unresectable Intrahepatic Cholangiocarcinoma
Authors: Franssen Stijn , Holster Jessica J. , Jolissaint Joshua S. , Nooijen Lynn E. , Cercek Andrea , D’Angelica Michael I. , Homs Marjolein Y. V. , Wei Alice C. , Balachandran Vinod P. , Drebin Jeffrey A. , Harding James J. , Kemeny Nancy E. , Kingham T. Peter , Klümpen Heinz-Josef , Mostert Bianca , Swijnenburg Rutger-Jan , Soares Kevin C. , Jarnagin William R. , Groot Koerkamp Bas 
Published: October 2023

Abstract
Background
A post-hoc analysis of ABC trials included 34 patients with liver-confined unresectable intrahepatic cholangiocarcinoma (iCCA) who received systemic chemotherapy with gemcitabine and cisplatin (gem-cis). The median overall survival (OS) was 16.7 months and the 3-year OS was 2.8%. The aim of this study was to compare patients treated with systemic gem-cis versus hepatic arterial infusion pump (HAIP) chemotherapy for liver-confined unresectable iCCA.

Methods
We retrospectively collected consecutive patients with liver-confined unresectable iCCA who received gem-cis in two centers in the Netherlands to compare with consecutive patients who received HAIP chemotherapy with or without systemic chemotherapy in Memorial Sloan Kettering Cancer Center.

Results
In total, 268 patients with liver-confined unresectable iCCA were included; 76 received gem-cis and 192 received HAIP chemotherapy. In the gem-cis group 42 patients (55.3%) had multifocal disease compared with 141 patients (73.4%) in the HAIP group (p = 0.023). Median OS for gem-cis was 11.8 months versus 27.7 months for HAIP chemotherapy (p < 0.001). OS at 3 years was 3.5% (95% confidence interval [CI] 0.0–13.6%) in the gem-cis group versus 34.3% (95% CI 28.1–41.8%) in the HAIP chemotherapy group. After adjusting for male gender, performance status, baseline hepatobiliary disease, and multifocal disease, the hazard ratio (HR) for HAIP chemotherapy was 0.27 (95% CI 0.19–0.39).

Conclusions
This study confirmed the results from the ABC trials that survival beyond 3 years is rare for patients with liver-confined unresectable iCCA treated with palliative gem-cis alone. With HAIP chemotherapy, one in three patients was alive at 3 years.
Editorial
Authors: Coelho Arnaldo Fernandes Matos , Weersma Laodicéia Amorim 
Published: October 2023

A edição 2022-1 da Revista Gestão em Análise – ReGeA traz, como fio condutor, a partilha-colaboração, diante da parceria na forma de Fast Track dos artigos apresentados no Encontro de Gestão e Negócios da Universidade Federal de Uberlândia - EGEN, por meio da Faculdade de Gestão e Negócios (FAGEN/UFU). O EGEN é um evento para debate científico, divulgação de pesquisas e práticas empresariais, integração entre a graduação e a pós-graduação dos cursos de Gestão e Negócios, facilitando a discussão de ideias, disseminação de experiências e informações sobre os campos de conhecimento em inovação, tecnologia e gestão (BARBOZA, 2017). [...].
Editorial
Authors: Weersma Laodicéia Amorim , Coelho Arnaldo Fernandes Matos 
Published: October 2023

Em meio ao contexto socioambiental que tende a se tornar cada vez mais complexo, novos modelos de produção e distribuição de bens materiais e simbólicos afloram nos debates acadêmicos e empresariais; em especial, as questões relacionadas à ruptura de modelos pautados basicamente pela lógica concorrencial e individualista. Nesse aspecto, acreditamos que as práticas colaborativas passam a ser um dos pilares para ultrapassarmos as fronteiras limitadoras, gerando soluções para diversos problemas e, assim, obtendo ganhos de eficiência e eficácia que permitem frutos de bem-estar social, vis-à-vis a equidade e a sustentabilidade ambiental. Segundo Ferreira (2018), a colaboração caracteriza-se como um processo recursivo em que duas ou mais pessoas ou organizações trabalham juntas para realizar objetivos comuns, pelo compartilhamento de conhecimento, aprendizagem e construção de consenso. Os avanços tecnológicos potencializaram essa atividade de tal forma que permitem um raio de alcance extraordinário entre os profissionais que a realizam. [...]