bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Cloud Warming Increases as Late Fall Arctic Sea Ice Cover Decreases
Authors: Arouf Assia , Chepfer Hélène , Kay Jennifer E. , L'Ecuyer Tristan S. , Lac Jean 
Published: February 2024

AbstractDuring the Arctic night, clouds regulate surface energy budgets through longwave warming alone. During fall, any increase in low‐level clouds will increase surface cloud warming and could potentially delay sea ice formation. While an increase in clouds due to fall sea ice loss has been observed, quantifying the surface warming is observationally challenging. Here, we use a new observational data set of surface cloud warming at instantaneous 330 m × 90 m spatial resolution. By instantaneously co‐locating surface cloud warming and sea ice observations in regions where sea ice varies, we find October large surface cloud warming values (>80 W m−2) are much more frequent (∼+50%) over open water than over sea ice. Notably, in November large surface cloud warming values (>80 W m−2) occur more frequently (∼+200%) over open water than over sea ice. These results suggest more surface warming caused by low‐level opaque clouds in the future as open water persists later into the fall.
Atmospheric and Land Drivers of Streamflow Flash Droughts in India
Authors: Singh Rajesh , Mishra Vimal 
Published: February 2024

AbstractStreamflow flash droughts (SFDs), characterized by a rapid decline in streamflow over a relatively short period, affect water availability, hydropower generation, and the ecosystem. However, atmospheric and land processes that drive SFDs in the monsoonal climate of India remain unexplored. Using observations, reanalysis data sets, and model simulations, we examined the critical drivers of SFDs in 64 catchments in India during the 1971–2018 period. We identified meteorological flash droughts (MFDs) using precipitation and SFDs using in situ observations and model simulations of streamflow. We show that precipitation deficit and anomalous high temperature, driven mainly by the summer monsoon breaks, lead to the development of MFDs. Antecedent baseflow conditions play a major role in the propagation of MFDs to SFDs. Favorable atmospheric conditions (driven by the monsoon breaks) cause MFDs, which translate to SFDs. High and low baseflow conditions limit the rapid decline in streamflow, which controls the occurrence of streamflow flash drought. On the other hand, favorable atmospheric conditions combined with moderate baseflow can trigger SFDs in India during the summer monsoon season. Moreover, humid catchments are more prone to propagation from MFDs to SFDs during the monsoon season in India. Understanding the crucial role of atmospheric and land drivers can assist in examining the occurrence of streamflow flash drought with implications for water resources planning and management.
Is the Inverted Field Gradient in the Catalina Schist Terrane Primary or Constructional?
Authors: Platt John P. , Schmidt William L. 
Published: February 2024

AbstractNew geothermometry using laser‐Raman data on carbonaceous material from low and intermediate grade rocks on Santa Catalina Island, California, together with existing thermobarometric data, show that there is a quasi‐continuous increase in peak metamorphic temperature from 327 ± 8°C in lawsonite blueschist facies rocks at the lowest structural levels, through ∼433°C in overlying epidote blueschists, 546 ± 20°C in albite‐epidote amphibolite facies rocks, to 650–730°C in amphibolite facies rocks at the top of the sequence. Rocks of different metamorphic grade are separated from one another by tectonic contacts across which temperature increases by ∼100°C in each case. Previously published geochronological data indicate that peak metamorphism in the highest grade rocks at 115 Ma preceded deposition of blueschist facies metasediments by ∼15 million years, so that the present inverted grade sequence does not represent an original inverted temperature gradient. The present structure results from progressive underplating of oceanic rocks in a cooling subduction zone following a high‐T metamorphic event at 115 Ma. An inverted temperature gradient of ≥100°C/km across the subduction channel likely existed during the high‐T event, decreased during underplating, and reached zero by ∼90 Ma.
CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease
Authors: Rybnicek Jonas , Chen Yuxiao , Milic Milos , Tio Earvin S. , McLaurin JoAnne , Hohman Timothy J. , De Jager Philip L. , Schneider Julie A. , Wang Yanling , Bennett David A. , Tripathy Shreejoy , Felsky Daniel , Lambe Evelyn K. 
Published: February 2024

AbstractChanges in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the nicotinic α5 subunit have been identified, but this gene has not been closely examined in the context of human aging and dementia. Therefore, we investigate the nicotinic α5 geneCHRNA5and the impact of relevant single nucleotide polymorphisms (SNPs) in prefrontal cortex from 922 individuals with matched genotypic andpost-mortemRNA sequencing in the Religious Orders Study and Memory and Aging Project (ROS/MAP). We find that a genotype robustly linked to increased expression ofCHRNA5(rs1979905A2) predicts significantly reduced cortical β-amyloid load. Intriguingly, co-expression analysis suggestsCHRNA5has a distinct cellular expression profile compared to other nicotinic receptor genes. Consistent with this prediction, single nucleus RNA sequencing from 22 individuals revealsCHRNA5expression is disproportionately elevated in chandelier neurons, a distinct subtype of inhibitory neuron known for its role in excitatory/inhibitory (E/I) balance. We show that chandelier neurons are enriched in amyloid-binding proteins compared to basket cells, the other major subtype of PVALB-positive interneurons. Consistent with the hypothesis that nicotinic receptors in chandelier cells normally protect against β-amyloid, cell-type proportion analysis from 549 individuals reveals these neurons show amyloid-associated vulnerability only in individuals with impaired function/trafficking of nicotinic α5-containing receptors due to homozygosity of the missenseCHRNA5SNP (rs16969968A2). Taken together, these findings suggest thatCHRNA5and its nicotinic α5 subunit exert a neuroprotective role in aging and Alzheimer’s disease centered on chandelier interneurons.
Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL
Authors: Li Jingyi , Liu Xingfeng , Liu Yuanyuan , Huang Fangmin , Liang Jiankun , Lin Yingying , Hu Fen , Feng Jianting , Han Zeteng , Chen Yushi , Chen Xuan , Lin Qiaofa , Wu Lanqin , Li Lisheng 
Published: February 2024

AbstractNecroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) is the hallmark of tumour necrosis factor α (TNF)-induced necroptosis. Here, we screened a small-molecule compound library and found that saracatinib inhibited TNF-induced necroptosis. By targeting MLKL, Saracatinib interfered with the phosphorylation, translocation, and oligomerization of MLKL induced by TNF. Consistently, mutation of the saracatinib-binding site of MLKL reduced the inhibitory effect of saracatinib on TNF-induced necroptosis. In an imiquimod (IMQ)-induced psoriasis mouse model, saracatinib effectively blocked MLKL phosphorylation and inflammatory responses in vivo. Taken together, these findings indicate that saracatinib inhibits necroptosis by targeting MLKL, providing a potential therapeutic approach for skin inflammation-related diseases such as psoriasis.
40 Hz light flickering promotes sleep through cortical adenosine signaling
Authors: Zhou Xuzhao , He Yan , Xu Tao , Wu Zhaofa , Guo Wei , Xu Xi , Liu Yuntao , Zhang Yi , Shang Huiping , Huang Libin , Yao Zhimo , Li Zewen , Su Lingya , Li Zhihui , Feng Tao , Zhang Shaomin , Monteiro Olivia , Cunha Rodrigo A. , Huang Zhi-Li , Zhang Kang , Li Yulong , Cai Xiaohong , Qu Jia , Chen Jiang-Fan 
Published: February 2024

AbstractFlickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical underpinning has hampered its therapeutic development. Here, we demonstrate that light flickering triggered an immediate and sustained increase (up to 3 h after flickering) in extracellular adenosine levels in the primary visual cortex (V1) and other brain regions, as a function of light frequency and intensity, with maximal effects observed at 40 Hz frequency and 4000 lux. We uncovered cortical (glutamatergic and GABAergic) neurons, rather than astrocytes, as the cellular source, the intracellular adenosine generation from AMPK-associated energy metabolism pathways (but not SAM-transmethylation or salvage purine pathways), and adenosine efflux mediated by equilibrative nucleoside transporter-2 (ENT2) as the molecular pathway responsible for extracellular adenosine generation. Importantly, 40 Hz (but not 20 and 80 Hz) light flickering for 30 min enhanced non-rapid eye movement (non-REM) and REM sleep for 2–3 h in mice. This somnogenic effect was abolished by ablation of V1 (but not superior colliculus) neurons and by genetic deletion of the gene encoding ENT2 (but not ENT1), but recaptured by chemogenetic inhibition of V1 neurons and by focal infusion of adenosine into V1 in a dose-dependent manner. Lastly, 40 Hz light flickering for 30 min also promoted sleep in children with insomnia by decreasing sleep onset latency, increasing total sleep time, and reducing waking after sleep onset. Collectively, our findings establish the ENT2-mediated adenosine signaling in V1 as the neurochemical basis for 40 Hz flickering-induced sleep and unravel a novel and non-invasive treatment for insomnia, a condition that affects 20% of the world population.
Hybrid AI-enhanced lightning flash prediction in the medium-range forecast horizon
Authors: Cavaiola Mattia , Cassola Federico , Sacchetti Davide , Ferrari Francesco , Mazzino Andrea 
Published: February 2024

AbstractTraditional fully-deterministic algorithms, which rely on physical equations and mathematical models, are the backbone of many scientific disciplines for decades. These algorithms are based on well-established principles and laws of physics, enabling a systematic and predictable approach to problem-solving. On the other hand, AI-based strategies emerge as a powerful tool for handling vast amounts of data and extracting patterns and relationships that might be challenging to identify through traditional algorithms. Here, we bridge these two realms by using AI to find an optimal mapping of meteorological features predicted two days ahead by the state-of-the-art numerical weather prediction model by the European Centre for Medium-range Weather Forecasts (ECMWF) into lightning flash occurrence. The prediction capability of the resulting AI-enhanced algorithm turns out to be significantly higher than that of the fully-deterministic algorithm employed in the ECMWF model. A remarkable Recall peak of about 95% within the 0-24 h forecast interval is obtained. This performance surpasses the 85% achieved by the ECMWF model at the same Precision of the AI algorithm.
Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties
Authors: Lee Jeong-Chan , Kim Su Yeong , Song Jayeon , Jang Hyowon , Kim Min , Kim Hanul , Choi Siyoung Q. , Kim Sunjoo , Jolly Pawan , Kang Taejoon , Park Steve , Ingber Donald E. 
Published: February 2024

AbstractDevelopment of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here, we describe a micrometer-thick, porous nanocomposite coating with both antifouling and electroconducting properties that enhances the sensitivity of electrochemical sensors. Nozzle printing of oil-in-water emulsion is used to create a 1 micrometer thick coating composed of cross-linked albumin with interconnected pores and gold nanowires. The layer resists biofouling and maintains rapid electron transfer kinetics for over one month when exposed directly to complex biological fluids, including serum and nasopharyngeal secretions. Compared to a thinner (nanometer thick) antifouling coating made with drop casting or a spin coating of the same thickness, the thick porous nanocomposite sensor exhibits sensitivities that are enhanced by 3.75- to 17-fold when three different target biomolecules are tested. As a result, emulsion-coated, multiplexed electrochemical sensors can carry out simultaneous detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid, antigen, and host antibody in clinical specimens with high sensitivity and specificity. This thick porous emulsion coating technology holds promise in addressing hurdles currently restricting the application of electrochemical sensors for point-of-care diagnostics, implantable devices, and other healthcare monitoring systems.
A zero-valent palladium cluster-organic framework
Authors: Liu Xiyue , McPherson James N. , Andersen Carl Emil , Jørgensen Mike S. B. , Larsen René Wugt , Yutronkie Nathan J. , Wilhelm Fabrice , Rogalev Andrei , Giménez-Marqués Mónica , Mínguez Espallargas Guillermo , Göb Christian R. , Pedersen Kasper S. 
Published: February 2024

AbstractAcquiring spatial control of nanoscopic metal clusters is central to their function as efficient multi-electron catalysts. However, dispersing metal clusters on surfaces or in porous hosts is accompanied by an intrinsic heterogeneity that hampers detailed understanding of the chemical structure and its relation to reactivities. Tethering pre-assembled molecular metal clusters into polymeric, crystalline 2D or 3D networks constitutes an unproven approach to realizing ordered arrays of chemically well-defined metal clusters. Herein, we report the facile synthesis of a {Pd3} cluster-based organometallic framework from a molecular triangulo-Pd3(CNXyl)6 (Xyl = xylyl; Pd3) cluster under chemically mild conditions. The formally zero-valent Pd3 cluster readily engages in a complete ligand exchange when exposed to a similar, ditopic isocyanide ligand, resulting in polymerization into a 2D coordination network (Pd3-MOF). The structure of Pd3-MOF could be unambiguously determined by continuous rotation 3D electron diffraction (3D-ED) experiments to a resolution of ~1.0 Å (>99% completeness), showcasing the applicability of 3D-ED to nanocrystalline, organometallic polymers. Pd3-MOF displays Pd03 cluster nodes, which possess significant thermal and aerobic stability, and activity towards hydrogenation catalysis. Importantly, the realization of Pd3-MOF paves the way for the exploitation of metal clusters as building blocks for rigidly interlocked metal nanoparticles at the molecular limit.
Interacting topological quantum chemistry in 2D with many-body real space invariants
Authors: Herzog-Arbeitman Jonah , Bernevig B. Andrei , Song Zhi-Da 
Published: February 2024

AbstractThe topological phases of non-interacting fermions have been classified by their symmetries, culminating in a modern electronic band theory where wavefunction topology can be obtained from momentum space. Recently, Real Space Invariants (RSIs) have provided a spatially local description of the global momentum space indices. The present work generalizes this real space classification to interacting 2D states. We construct many-body local RSIs as the quantum numbers of a set of symmetry operators on open boundaries, but which are independent of the choice of boundary. Using the U(1) particle number, they yield many-body fragile topological indices, which we use to identify which single-particle fragile states are many-body topological or trivial at weak coupling. To this end, we construct an exactly solvable Hamiltonian with single-particle fragile topology that is adiabatically connected to a trivial state through strong coupling. We then define global many-body RSIs on periodic boundary conditions. They reduce to Chern numbers in the band theory limit, but also identify strongly correlated stable topological phases with no single-particle counterpart. Finally, we show that the many-body local RSIs appear as quantized coefficients of Wen-Zee terms in the topological quantum field theory describing the phase.
Data-centric artificial olfactory system based on the eigengraph
Authors: Sung Seung-Hyun , Suh Jun Min , Hwang Yun Ji , Jang Ho Won , Park Jeon Gue , Jun Seong Chan 
Published: February 2024

AbstractRecent studies of electronic nose system tend to waste significant amount of important data in odor identification. Until now, the sensitivity-oriented data composition has made it difficult to discover meaningful data to apply artificial intelligence in terms of in-depth analysis for odor attributes specifying the identities of gas molecules, ultimately resulting in hindering the advancement of the artificial olfactory technology. Here, we realize a data-centric approach to implement standardized artificial olfactory systems inspired by human olfactory mechanisms by formally defining and utilizing the concept of Eigengraph in electrochemisty. The implicit odor attributes of the eigengraphs were mathematically substantialized as the Fourier transform-based Mel-Frequency Cepstral Coefficient feature vectors. Their effectiveness and applicability in deep learning processes for gas classification have been clearly demonstrated through experiments on complex mixed gases and automobile exhaust gases. We suggest that our findings can be widely applied as source technologies to develop standardized artificial olfactory systems.
Decoupled oxidation process enabled by atomically dispersed copper electrodes for in-situ chemical water treatment
Authors: Yu Ziwei , Jin Xuming , Guo Yang , Liu Qian , Xiang Wenyu , Zhou Shuai , Wang Jiaying , Yang Dailin , Wu Hao Bin , Wang Juan 
Published: February 2024

AbstractIn-situ wastewater treatment has gained popularity due to cost and energy savings tailored to water sources and user needs. However, this treatment, particularly through advanced oxidation processes (AOPs), poses ecological risks due to the need for strong oxidizing agents. Here, we present a decoupled oxidation process (DOP) using single-atom copper-modified graphite felt electrodes. This process creates a positive potential difference (ΔE ~ 0.5 V) between spatially isolated oxidants and organics and drives electron transfer-based redox reactions. The approach avoids the drawbacks of conventional AOPs, while being capable of treating various recalcitrant electron-rich organics. A floating water treatment device designed based on the DOP approach can degrade organic molecules in large bodies of water with oxidants stored separately in the device. We demonstrate that over 200 L of contaminated water can be treated with a floating device containing only 40 mL of oxidant (10 mM peroxysulphate). The modular device can be used in tandem structures on demand, maximizing water remediation per unit area. Our result provides a promising, eco-friendly method for in-situ water treatment that is unattainable with existing techniques.
Hydraulic-driven adaptable morphing active-cooling elastomer with bioinspired bicontinuous phases
Authors: Yu Dehai , Wang Zhonghao , Chi Guidong , Zhang Qiubo , Fu Junxian , Li Maolin , Liu Chuanke , Zhou Quan , Li Zhen , Chen Du , Song Zhenghe , He Zhizhu 
Published: February 2024

AbstractThe active-cooling elastomer concept, originating from vascular thermoregulation for soft biological tissue, is expected to develop an effective heat dissipation method for human skin, flexible electronics, and soft robots due to the desired interface mechanical compliance. However, its low thermal conduction and poor adaptation limit its cooling effects. Inspired by the bone structure, this work reports a simple yet versatile method of fabricating arbitrary-geometry liquid metal skeleton-based elastomer with bicontinuous Gyroid-shaped phases, exhibiting high thermal conductivity (up to 27.1 W/mK) and stretchability (strain limit >600%). Enlightened by the vasodilation principle for blood flow regulation, we also establish a hydraulic-driven conformal morphing strategy for better thermoregulation by modulating the hydraulic pressure of channels to adapt the complicated shape with large surface roughness (even a concave body). The liquid metal active-cooling elastomer, integrated with the flexible thermoelectric device, is demonstrated with various applications in the soft gripper, thermal-energy harvesting, and head thermoregulation.
Morphometric study applied to testicular and epididymis hydatids torsion
Authors: Barbosa Renato G. , Favorito Luciano Alves , Sampaio Francisco J. B. 
Published: February 2024

AbstractTwisted testicular appendages had difficult differential diagnosis with testicular torsion. The objective of this paper is to evaluate the number, shape, size and determine the laterality pattern of the testicular and epididymal hydatids and evaluate the correlations between the length and width of the testicular and epididymal hydatids with testicular measurements. We analyzed 60 fixed cadavers and 16 patients with prostate cancer without previous hormonal treatment undergoing bilateral orchiectomy, totalizing 76 units and 152 testicles. In relation to the testicular appendices, we analyzed the following situations: absence of testicular and epididymis appendages, presence of a testicular appendix, presence of epididymis appendix, and presence of testicular and epididymis appendix. We measured the length, width and thickness of the testis and classified the appendages as sessile or pedicled. Chi-square test was used to verify associations between categorical variables. McNemar Test was used to verify differences between the percentages of right and left appendages. Correlations between quantitative measures were evaluated using the Pearson Correlation Coefficient (p < 0.05). In 50 cases (65.78%) we observed the presence of some type of appendices, in 34 cases (44.72%) we observed the presence of testicular appendices and in 19 cases (25%) the presence of epididymal appendices. We observed the presence of pedicled appendices in 39 cases (51.32%), with 25 of the cases (32.89%) of pedicled testicular appendices and 14 of the cases (18.42%) of pedicled epididymal appendages, with a significant association between the occurrence of appendices on the right and left sides (p < 0.001). Testicular hydatids were present in around two thirds of our sample being pedunculated in almost half of the cases with bilateral similarity. There is a significant chance in cases of twisted appendices that the same anatomical characteristics are present on the opposite side, which is a factor that tends to indicate the need for contralateral surgical exploration in cases of torsion, however studies with larger samples are needed to confirm these findings.