bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin
Authors: Chae Song Ah , Du Min , Zhu Mei-Jun , Son Jun Seok 
Published: November 2023

Abstract
Placental chorion/labyrinth trophoblasts are energy demanding which is met by the mitochondrial oxidative phosphorylation. Exercise enhances placental development and mitochondrial biogenesis, but the underlying mechanisms remain poorly understood. To address, female C57BL/6 J mice were randomly assigned into two groups: a control group and an exercise (EX) group. All animals were acclimated to treadmill exercise for 1 week before mating, but only the EX group was subjected to daily exercise during pregnancy from embryonic day (E) 1.5 to E16.5. Placenta were collected at E18.5 for biochemical and histochemical analyses, and primary trophoblast cells were isolated from the E18.5 placenta for further analyses. The data showed that exercise during pregnancy promoted the expression of syncytiotrophoblast cell markers, indicating trophoblast cell differentiation, which was closely associated with elevated mitochondrial biogenesis and oxidative metabolism in the E18.5 placenta. In addition, exercise during pregnancy activated peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α), which was associated with upregulated placental α-ketoglutarate and the expression of isocitrate dehydrogenases and ten-eleven translocations, facilitating DNA demethylation of the Pgc1a promoter. Furthermore, exercise upregulated fibronectin type III domain containing 5 expression and the secretion of its cleaved form, irisin, which is known to activate PGC-1α. These data suggest that exercise-induced activation of PGC-1α, via epigenetic modifications, is responsible for promoting mitochondrial energy metabolism and chorion/labyrinth trophoblast development.
Multiscale adaptive management of social–ecological systems
Authors: Garmestani Ahjond , Allen Craig R , Angeler David G , Gunderson Lance , Ruhl J B 
Published: November 2023

Abstract
Adaptive management is an approach for stewardship of social–ecological systems in circumstances with high uncertainty and high controllability. Although they are largely overlooked in adaptive management (and social–ecological system management), it is important to account for spatial and temporal scales to mediate within- and cross-scale effects of management actions, because cross-scale interactions increase uncertainty and can lead to undesirable consequences. The iterative nature of an adaptive approach can be expanded to multiple scales to accommodate different stakeholder priorities and multiple ecosystem attributes. In this Forum, we introduce multiscale adaptive management of social–ecological systems, which merges adaptive management with panarchy (a multiscale model of social–ecological systems) and demonstrate the importance of this approach with case studies from the Great Plains of North America and the Platte River Basin, in the United States. Adaptive management combined with a focus on the panarchy model of social–ecological systems can help to improve the management of social–ecological systems.
Elevated mortality among the second-generation (children of migrants) in Europe: what is going wrong? A review
Authors: Wallace Matthew , Hiam Lucinda , Aldridge Robert 
Published: November 2023

Abstract

Introduction
The ‘second-generation’ (i.e. the children of migrants) represent one of the fastest growing subpopulations of the child and young adult populations in Europe today. The research so far appears to indicate that their mortality risk is elevated relative to people with non-migrant backgrounds.

Sources of data
Peer-reviewed publications.

Areas of agreement
Second-generation status is a clear marker of elevated mortality risk in Europe in early life (including stillbirth, perinatal, neonatal and infant mortality) and adulthood, particularly if the parent(s) were born outside of Europe. Socioeconomic inequality plays an important, albeit rarely defining, role in these elevated risks.

Areas of controversy
It remains unclear what causes-of-death are driving these elevated mortality risks. The exact influence of (non-socioeconomic) explanatory factors (e.g. health care, racism & discrimination, and factors related to integration) on the elevated mortality risks of the second-generation also remains unclear.

Growing points
The second-generation will continue to grow and diversify in Europe; we must intervene to address these inequalities now.

Areas timely for developing research
Place more emphasis on the complexity of migration background, specific causes-of-death, and understanding the roles of explanatory factors beyond socioeconomic background.
Optimization of patient-specific stereo-EEG recording sensitivity
Authors: Dessert Grace E , Thio Brandon J , Grill Warren M 
Published: November 2023

Abstract
Stereo-EEG is a minimally invasive technique used to localize the origin of epileptic activity (the epileptogenic zone) in patients with drug-resistant epilepsy. However, current stereo-EEG trajectory planning methods are agnostic to the spatial recording sensitivity of implanted electrodes. In this study, we used image-based patient-specific computational models to design optimized stereo-EEG electrode configurations. Patient-specific optimized electrode configurations exhibited substantially higher recording sensitivity than clinically implanted configurations, and this may lead to a more accurate delineation of the epileptogenic zone. The optimized configurations also achieved equally good or better recording sensitivity with fewer electrodes compared with clinically implanted configurations, and this may reduce the risk for complications, including intracranial haemorrhage. This approach improves localization of the epileptogenic zone by transforming the clinical use of stereo-EEG from a discrete ad hoc sampling to an intelligent mapping of the regions of interest.
Treating erythroplasia of Queyrat with photodynamic therapy following circumcision and dermabrasion
Authors: Yao Shulan , Lin Zheng , Li Yan , Lu Bin 
Published: November 2023

Abstract
We describe a case of a patient with erythroplasia of Queyrat located on the whole glans and end of the prepuce that was successfully treated with three courses of photodynamic therapy after the completion of circumcision and dermabrasion. Skin lesions disappeared after receiving this combination of treatments and have not recurred during the past 6 months of follow-up.
Differential diagnosis of red scalp: the importance of trichoscopy
Authors: Waśkiel-Burnat Anna , Czuwara Joanna , Blicharz Leszek , Olszewska Małgorzata , Rudnicka Lidia 
Published: November 2023

Abstract
Red scalp is a common complaint that may constitute a diagnostic and therapeutic challenge in daily clinical practice. Among the numerous diseases to cause diffuse scalp erythema are psoriasis, seborrhoeic dermatitis, contact dermatitis, diffuse lichen planopilaris, dermatomyositis and scalp rosacea. Accurate diagnosis is crucial for optimal treatment outcomes. Histology most frequently discriminates the underlying condition, but it requires scalp biopsy. In many cases, the combination of clinical examination and trichoscopy is sufficient for establishing the correct diagnosis. The main trichoscopic features of psoriasis are silver–white scaling, regularly distributed dotted (glomerular) vessels or twisted red loops, and punctate haemorrhages. Yellowish–white scaling and thin arborizing vessels are typical features of seborrhoeic dermatitis. Contact dermatitis is characterized by the presence of yellow exudate and polymorphic vessels, while perifollicular scaling and erythema with the lack of follicular openings are typical findings in lichen planopilaris. In scalp dermatomyositis, tortuous and arborizing vessels with interfollicular and perifollicular pigmentation may be detected. The most characteristic features of scalp rosacea are perifollicular scaling and polygonal/arborizing vessels. This review also summarizes histological features and therapeutic options for these conditions.
Therapeutic Phages as Modulators of the Immune Response: Practical Implications
Authors: Górski Andrzej , Międzybrodzki Ryszard , Jończyk-Matysiak Ewa , Kniotek Monika , Letkiewicz Sławomir 
Published: November 2023

Abstract
While the medical community awaits formal proof of the efficacy of phage therapy, as is required by evidence-based medicine, existing data suggest that phages could also be applied based on their non-antibacterial action, especially phage-mediated immunomodulation. Promising avenues have been revealed by findings indicating that phages may mediate diverse actions in the immune system, while the list of phages able to dampen the aberrant immunity associated with a variety of disorders continuously grows. Here we summarize what is known in this field and possible options for the future. While available data are still scarce and preliminary, it appears that “phage repurposing” is worthy of more research, which could reveal new perspectives on applying phage therapy in contemporary medicine.
Therapeutic Phage Monitoring: A Review
Authors: Bosco Kiran , Lynch Stephanie , Sandaradura Indy , Khatami Ameneh 
Published: November 2023

Abstract
With the global rise in antimicrobial resistance, there has been a renewed interest in the application of therapeutic phages to treat bacterial infections. Therapeutic phage monitoring (TPM) is proposed as an essential element of phage therapy (PT) protocols to generate data and fill knowledge gaps regarding the in vivo efficacy of therapeutic phages, patients’ immune responses to PT, and the wider ecological effects of PT. By monitoring phage concentrations in blood and tissues, together with immune responses and possible ecological changes during PT, TPM may enable the optimization of dosing and the implementation of precision medicine approaches. Furthermore, TPM can validate diagnostic surrogates of efficacy, direct research efforts, and establish quality assurance indicators for therapeutic phage products. Thus, TPM holds great potential for enhancing our understanding of the multidirectional phage–bacteria–host interactions and advancing “best practice” PT, ultimately improving patient care.
Advanced Manufacturing, Formulation and Microencapsulation of Therapeutic Phages
Authors: Malik Danish J , Goncalves-Ribeiro Henrique , GoldSchmitt Dirk , Collin Joe , Belkhiri Aouatif , Fernandes Diogo , Weichert Henry , Kirpichnikova Anya 
Published: November 2023

Abstract
Manufacturing and formulation of stable, high purity, and high dose bacteriophage drug products (DPs) suitable for clinical usage would benefit from improved process monitoring and control of critical process parameters that affect product quality attributes. Chemistry, Manufacturing, and Controls (CMC) for both upstream (USP) and downstream processes (DSP) need mapping of critical process parameters (CPP) and linking these to critical quality attributes (CQA) to ensure quality and consistency of phage drug substance (DS) and DPs development. Single-use technologies are increasingly becoming the go-to manufacturing option with benefits both for phage bioprocess development at the engineering run research stage and for final manufacture of the phage DS. Future phage DPs under clinical development will benefit from implementation of process analytical technologies (PAT) for better process monitoring and control. These are increasingly being used to improve process robustness (to reduce batch-to-batch variability) and productivity (yielding high phage titers). Precise delivery of stable phage DPs that are suitably formulated as liquids, gels, solid-oral dosage forms, and so forth, could significantly enhance efficacy of phage therapy outcomes. Pre-clinical development of phage DPs must include at an early stage of development, considerations for their formulation including their characterization of physiochemical properties (size, charge, etc.), buffer pH and osmolality, compatibility with regulatory approved excipients, storage stability (packaging, temperature, humidity, etc.), ease of application, patient compliance, ease of manufacturability using scalable manufacturing unit operations, cost, and regulatory requirements.
Collecting Multi-country Retrospective Antimicrobial Consumption and Use Data: Challenges and Experience
Authors: Prifti Kristi , Chi Kyu-young Kevin , Eraly Emmanuel , Joh Hea Sun , Sujan Mohammad Julhas , Poudyal Nimesh , Marks Florian , Holm Marianne 
Published: November 2023

Abstract
Excessive or inappropriate antimicrobial use contributes to antimicrobial resistance, emphasizing the need to monitor and document the types and quantities of antibiotics used. Thus, data on antimicrobial consumption (AMC) and antimicrobial usage (AMU) are key in informing and promoting judicious use. Our study, conducted during 2019–2023, as part of the CAPTURA project, aimed to understand the state of data availability and quality for AMC and AMU monitoring in Asia. In this article, we describe the challenges and opportunities faced and provide examples of AMU and AMC analysis. World Health Organization (WHO) and country-tailored methodologies and tools were applied to collect retrospective data from 2016 to 2019 in Bangladesh, Bhutan, Laos, Nepal, Pakistan, Papua New Guinea, Sri Lanka, and Timor-Leste. The primary indicator for national AMC was total level of consumption, expressed as total defined daily doses (DDD) per 1000 inhabitants per day for the year or period of data collected. For facility AMC and AMU, the primary indicator was total DDD per admissions per day for the year or period of data collected. Although many countries faced infrastructural challenges in data collection and storage, we managed to collect and analyze AMC data from 6 countries and AMU data from 5. The primary indicators, and additional findings, were visualized to facilitate dissemination and promote the development of action plans. Looking ahead, it is crucial that future initiatives empower each country to establish surveillance infrastructures tailored to their unique contexts, ensuring sustainable progress in the fight against antimicrobial resistance.
Enhancing Auditory Brainstem Response Classification Based On Vision Transformer
Authors: Abubakir Ahmed Hunar , Majidpour Jafar , Hussein Ahmed Mohammed , Kais Jameel Samer , Majidpour Amir 
Published: November 2023

Abstract
A method for testing the health of ear’s peripheral auditory nerve and its connection to the brainstem is called an auditory brainstem response (ABR). Manual quantification of ABR tests by an audiologist is not only costly but also time-consuming and susceptible to errors. Recently in machine learning have prompted a resurgence of research into ABR classification. This study presents an automated ABR recognition model. The initial step in our design process involves collecting a dataset by extracting ABR test images from sample test reports. Subsequently, we employ an elastic distortion approach to generate new images from the originals, effectively expanding the dataset while preserving the fundamental structure and morphology of the original ABR content. Finally, the Vision Transformer method was exploited to train and develop our model. In the testing phase, the incorporation of both the newly generated and original images yields an impressive accuracy rate of 97.83%. This result is noteworthy when benchmarked against the latest research in the field, underscoring the substantial performance enhancement achieved through the utilization of generated data.
Pharmacological Therapies for the Management of Fistulizing Crohn’s Disease: A Systematic Review and Meta-Analysis
Authors: Vuyyuru Sudheer K , Solitano Virginia , Narula Neeraj , Lee Matthew J , MacDonald John K , McCurdy Jeffrey D , Singh Siddharth , Ma Christopher , Jairath Vipul 
Published: November 2023

Abstract

Background
Fistulas are a debilitating complication of Crohn’s disease [CD]. We conducted a systematic review to assess the efficacy of medical therapies for fistulizing CD.

Methods
MEDLINE, Embase, and CENTRAL were searched on May 26, 2022, for randomized controlled trials [RCTs] of pharmacological therapy in adults with fistulizing CD. The primary outcome was induction and maintenance of fistula response. Pooled risk ratios [RRs] and 95% confidence intervals [CIs] were calculated. GRADE was used to assess the certainty of evidence.

Results
Thirty-eight RCTs were included. Nineteen trials [50%] exclusively involved perianal fistula. The remaining studies included some participants with non-perianal fistula. Pooled RRs for anti-tumour necrosis factor [TNF] agents were not statistically significant for induction [RR 1.36, 95% CI 0.97–1.91] or maintenance of fistula response [RR 1.48, 95% CI 0.97–2.27]. However, in a sensitivity analysis of studies with fistula response as the primary outcome, anti-TNFs were superior to placebo for induction [RR 1.94, 95% CI 1.10–3.41] and maintenance [RR 1.88, 95% CI 1.23–2.88] of fistula response. Oral small molecules [RR 2.56, 95% CI 1.18–5.53] and mesenchymal stem cell [MSC] therapy [RR 1.26, 95% CI 1.01–1.57] were effective for induction of fistula response. Ustekinumab was associated with maintenance of fistula response [RR 1.80, 95% CI 1.04–3.11]. Vedolizumab was not superior to placebo. The certainty of evidence ranged from very low to moderate.

Conclusion
Very low- to moderate-certainty evidence suggests that anti-TNF therapy, oral small molecules, ustekinumab, and MSCs are effective for perianal fistulizing CD. Dedicated fistula studies evaluating biologics and small molecules are needed.
Higher Serum Infliximab Concentrations Following Subcutaneous Dosing are Associated with Deep Remission in Patients with Inflammatory Bowel Disease
Authors: Roblin Xavier , Nancey Stéphane , Papamichael Konstantinos , Duru Gérard , Flamand Mathurin , Kwiatek Sandy , Cheifetz Adam , Fabien Nicole , Barrau Mathilde , Paul Stéphane 
Published: November 2023

Abstract

Background
The relationship between subcutaneous infliximab [SC-IFX] concentrations and favourable therapeutic outcomes in patients with Crohn’s disease [CD] and ulcerative colitis [UC] remains elusive.

Patients and Methods
This cross-sectional study included consecutive adult patients with inflammatory bowel disease [IBD] treated with SC-IFX at a maintenance dose of 120 mg/2 weeks. Investigated therapeutic outcomes included sustained clinical remission; composite clinical and biomarker remission [clinical remission and C-reactive protein &lt;5 mg/L]; biochemical remission [faecal calprotectin &lt;250 µg/g]; and deep remission [clinical, biological, and biochemical remission].

Results
Of 91 patients identified, 71 qualified for inclusion in the study [70% with CD; 27% with concomitant immunomodulators]. At the time of drug concentration measurement [median 13.5 months after switch], 55 [77%] patients had sustained clinical remission; n = 44 [62%] composite clinical and biomarker remission; n = 40 [56%] biochemical remission; and n = 31 [43%] deep remission. The mean SC-IFX concentrations were significantly higher in patients with sustained clinical remission [p = 0.014]; composite clinical and biomarker remission [p = 0.003]; biochemical remission [p &lt; 0.001]; and deep remission [p &lt; 0.001] compared to patients without having these outcomes. In multivariate analysis, SC-IFX concentration was the only factor independently associated with sustained clinical remission (odds ratio [OR]: 4.7, 95% confidence interval [CI]: 3.1–12.2, p = 0.005); clinical and biomarker remission [OR: 9.21, 95% CI: 6.09–18.7, p = 0.006]; biochemical remission [OR: 37, 95% CI: 14–39.3, p &lt; 0.001]; and deep remission [OR: 29, 95% CI: 15.7–37.4, p &lt; 0.001]. The optimal SC-IFX concentration cut-off associated with deep remission based on ROC analysis was 20 µg/mL [sensitivity: 0.91, specificity: 0.80, accuracy: 0.85]. Combination with an immunomodulator failed to improve SC-IFX pharmacokinetics.

Conclusion
Higher SC-IFX concentrations are associated with higher rates of favourable therapeutic outcomes in IBD patients. Serum SC-IFX concentrations &gt;20 µg/mL were significantly associated with deep remission.
The French ecology of medical care. A nationwide population-based cross sectional study
Authors: Laporte Catherine , Fortin Frédéric , Dupouy Julie , Darmon David , Pereira Bruno , Authier Nicolas , Delorme Jessica , Chenaf Chouki , Maisonneuve Hubert , Schuers Matthieu 
Published: November 2023

Abstract

Purpose
Studies in the United States, Canada, Belgium, and Switzerland showed that the majority of health problems are managed within primary health care; however, the ecology of French medical care has not yet been described.

Methods
Nationwide, population-based, cross sectional study. In 2018, we included data from 576,125 beneficiaries from the General Sample of Beneficiaries database. We analysed the reimbursement of consultations with (i) a general practitioner (GP), (ii) an outpatient doctor other than a GP, (iii) a doctor from a university or non-university hospital; and the reimbursement of (iv) hospitalization in a private establishment, (v) general hospital, and (vi) university hospital. For each criterion, we calculated the average monthly number of reimbursements reported on 1,000 beneficiaries. For categorical variables, we used the χ2 test, and to compare means we used the z test. All tests were 2-tailed with a P-value &lt; 5% considered significant.

Results
Each month, on average, 454 (out of 1,000) beneficiaries received at least 1 reimbursement, 235 consulted a GP, 74 consulted other outpatient doctors in ambulatory care and 24 in a hospital, 13 were hospitalized in a public non-university hospital and 10 in the private sector, and 5 were admitted to a university hospital. Independently of age, people consulted GPs twice as much as other specialists. The 13–25-year-old group consulted the least. Women consulted more than men. Individuals covered by complementary universal health insurance had more care.

Conclusions
Our study on reimbursement data confirmed that, like in other countries, in France the majority of health problems are managed within primary health care.
Array analysis of seismo-volcanic activity with distributed acoustic sensing
Authors: Biagioli Francesco , Métaxian Jean-Philippe , Stutzmann Eléonore , Ripepe Maurizio , Bernard Pascal , Trabattoni Alister , Longo Roberto , Bouin Marie-Paule 
Published: November 2023

SUMMARY
Continuous seismic monitoring of volcanoes is challenging due to harsh environments and associated hazards. However, the investigation of volcanic phenomena is essential for eruption forecasting. In seismo-volcanic applications, distributed acoustic sensing (DAS) offers new possibilities for long-duration surveys. We analyse DAS strain rate signals generated by volcanic explosions and tremor at Stromboli volcano (Italy) recorded along 1 km of dedicated fibre-optic cable. We validate DAS recordings with colocated nodal seismometers. Converting node measurements to strain rate, we observe a perfect match in phase between DAS and node waveforms. However, DAS amplitudes appear to be around 2.7 times smaller than those of node records, which we explain as due to the inefficient ground-to-fibre strain transfer in the loose cable. We invert time delays between strain rate waveforms and confirm that the DAS enables us to retrieve a dominant and persistent seismic source in the proximity of active craters. This stable source location is confirmed by node array analyses. Despite an observed high noise level of strain rate signals outside a range of 2–15 Hz, our results demonstrate the potential of this new technology in monitoring volcanic areas.