bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staphylococcus aureus y Streptococcus pneumoniae: INFECCIONES NOSOCOMIALES QUE REPRESENTAN UNA AMENAZA APREMIANTE PARA LA SALUD PÚBLICA
Authors: Morales Gustavo , Tapia Jearim , Baez Antonio , Quintero Veronica , Ramírez Veronica , Munive José Antonio 
Published: February 2024

Los antibióticos son un grupo de medicamentos que son utilizados para el control de infecciones causadas por bacterias y parásitos. La resistencia a los antibióticos es originada por un mal uso en el tratamiento de las infecciones, y se produce cuando los microorganismos logran adaptarse y crecer en presencia de medicamentos que alguna vez los impactaron. El débil control en la utilización de estos agentes ha propiciado que en la naturaleza se distribuyan organismos resistentes a los antimicrobianos prescritos popularmente, lo cual se ha convertido en un problema de salud pública. La infección por microorganismos resistentes a diferentes compuestos antimicrobianos conduce a enfermedades graves, ingresos hospitalarios prolongados, aumento en los costos de atención médica y en medicamentos de segunda línea, y fracasos en los tratamientos. Uno de los patógenos del cual se ha descrito una alta incidencia en infecciones nosocomiales, identificado como multidrogorresistentes, de mal pronóstico en pacientes inmunosuprimidos, es Staphylococcus aureus, el cual se caracteriza por ser la principal causa de bacteriemia nosocomial. Otro de los principales patógenos responsables de muchos de los casos de neumonía reportados en niños y adultos es Streptococcus pneumoniae. La información sobre los diferentes mecanismos de resistencia permite recalcar la urgencia e importancia de encontrar nuevas alternativas terapéuticas para combatir las infecciones nosocomiales. La generación y propagación de cepas multidrogorresistentes debe prevenirse mediante restricciones severas en el uso de los antibióticos, respetando la prescripción, incluyendo el número de dosis y el periodo de tiempo de su ingesta, así como evitando la automedicación.
Palabras clave
Staphylococcus aureus, Streptococcus pneumoniae, multidrogorresistencia, bacteria, antibiótico
LOS SISTEMAS DE DETECCIÓN DE QUORUM (QUORUM SENSING) O CÓMO “SOCIALIZAN” LAS BACTERIAS
Authors: López-Pliego Liliana , Castañeda Miguel 
Published: February 2024

Aunque por muchos años se pensó que era poco probable que las bacterias se comunicaran entre sí estableciendo un comportamiento “social”, numerosos estudios realizados en las tres últimas décadas revelaron que las bacterias si se comunican entre sí, y no solo eso, se pueden censar o contar. Los sistemas de comunicación que usan las bacterias para tal fin son llamados sistemas de Detección de Quorum (Quorum Sensing). En estos sistemas regularmente se usa una molécula señuelo conocida como autoinductor, la cual es producida individualmente por cada una de las células de la colonia. Después, el autoinductor es transportado al exterior de la célula donde se acumula progresivamente al aumentar el número de bacterias de la colonia. Cuando se alcanza una concentración alta del autoinductor, es detectado por unas moléculas receptoras especiales, que a su vez activan la expresión de genes que responden a la densidad celular de la colonia.
Del suelo a la granja: vacunas de origen vegetal con fines terapéuticos para animales de corral
Authors: Rodríguez-Cortés Aidé , Gutiérrez-Santos Itzel O. , Zenteno-Santacruz Zoe 
Published: February 2024

Desde hace varios años se ha demostrado mediante diversas investigaciones que las plantas son una plataforma robusta para la expresión de péptidos con actividad inmunológica que pueden ser utilizados como vacunas. El uso de organismos vegetales es muy conveniente porque resulta económico, es escalable y permite que la integración del material genético se realice mediante técnicas ya bien caracterizadas. La inmunización veterinaria con vacunas generadas en plantas representa una opción viable para proteger a animales de granja de diversos patógenos, con esto se pueden evitar pérdidas económicas o emergencias de salud. A la fecha sólo la vacuna contra la enfermedad de Newcastle está disponible en el mercado ya que existen muchas restricciones por parte de entidades reguladoras. A pesar de esto, las investigaciones respecto a las vacunas producidas en plantas siguen avanzando a lo largo del mundo, presentándonos una perspectiva favorable para el futuro.
Palabras claves: Vacunas veterinarias. Planta. Enfermedad. Salud animal

Abstract

For several years it has been demonstrated through various investigations that plants are a robust platform for the expression of peptides with immunological activity that can be used as vaccines. The use of plant organisms is very convenient because it is inexpensive, scalable and allows the integration of genetic material using well characterized techniques. Veterinary immunization with plant-generated vaccines represents a viable option to protect farm animals from various pathogens, thereby avoiding economic losses or health emergencies. To date, only the vaccine against Newcastle disease is commercially available because there are many restrictions by regulatory agencies, in spite of this. research on plant-derived vaccines continues to advance throughout the world, presenting a favorable outlook for the future.

Keywords: Veterinary vaccines. Plant. Disease, Animal health
SYSTEMATIC LITERATURE REVIEW (SLR): EFEKTIVITAS KOMPENSASI DALAM MENINGKATKAN MOTIVASI KERJA DAN PRESTASI KERJA DI LEMBAGA PENDIDIKAN
Authors: Ningsih Wulandari , Rindaningsih Ida 
Published: February 2024

Salah satu upaya yang dapat dilakukan agar pegawai termotivasi dalam melaksanakan tugasnya dengan profesional yaitu dengan memberikan sebuah kompensasi atau bentuk imbalan jasa karena banyak pegawai yang memiliki kualifikasi pendidikan yang memadai dan linier di bidangnya merasa tidak puas dengan pekerjaan dan gaji yang mereka dapatkan, sehingga instansi atau lembaga pendidikan terkait harus memberikan kompensasi yang layak Kompensasi merupakan sebuah penghargaan yang diberikan kepada pegawai sebagai bentuk balas jasa karena sudah berkontribusi dalam melaksanakan tugasnya sesuai ketentuan organisasi. Penelitian ini menggunakan metode Systematic Literature Review (SLR). Dalam penelitian ini terdapat beberapa tahapan yang telah dilalui oleh peneliti yaitu menentukan pertanyaan penelitian, mencari beberapa literatur tentang efektivitas kompensasi dalam meningkatkan motivasi kerja dan prestasi kerja, melakukan seleksi literatur yang relevan, menyajikan data, mengolah data, serta menarik kesimpulan. Banyaknya artikel yang dianalisis dalam penelitian ini adalah 10 artikel. Berdasarkan kajian literature yang dilakukan, menunjukkan hasil efektifivas kompensasi dalam meningkatkan motivasi kerja dan prestasi kerja di Lembaga pendidikan sangat baik.
“More room for learning”: Early Childhood Educators’ reflections on their classroom environment
Authors: Walker Stephanie 
Published: February 2024

<p>Early childhood educators’ (ECE) relationship to and needs in regard to classroom space have, for the most part, been overlooked or disregarded. This study xamines how classroom space impacts educators’ view of themselves and considers the role that auspice plays in ECEs’ experiences in those spaces. Using self- determination theory and feminist ethics of care, this study draws upon the reflections of seven Ontario ECEs in non-profit and for-profit child care to consider how their workspace impacts their sense of self. Using photo-elicitation methodologies, this study found that ECEs viewed themselves more positively when their space had elements that promoted relationships, autonomy and decision-making abilities, and opportunities to demonstrate competency and skills. Additionally, non-profit child care was found to be a more supportive auspice compared to for-profit child care. The recent pandemic, COVID-19 was also shown to have an effect on the findings. </p>
The Effect of Individual Compounds from <i>Rubus chamaemoruson</i> Hemostasis <i>in vitro</i>
Authors: Luzhanin V. G. , Samorodov A. V. , Whaley A. K. , Whaley A. O. , Yakovlev G. P. , Samylina I. A. 
Published: February 2024

Introduction. One of the key tasks of the pharmaceutical industry is the search for new promising compounds – potential drug candidates. Natural objects, especially plants, have long been rich sources of new molecules and are widely used in the global food and pharmaceutical industries. Cloudberry (Rubus chamaemorus L.) is a perennial herb from the Rosaceae family. The fruits and leaves of R. chamaemorus contain a wide variety of polyphenolic secondary metabolites – hydrolysable/condensed tannins and flavonoids. Extracts enriched by polyphenols showed significant antiproliferative activity and inhibition of cell growth, and also induce cell apoptosis. As a result of our previous phytochemical research of R. chamaemorus leaves, five polyphenolic secondary metabolites belonging to the classes of tannins and flavonoids were isolated and characterized.Aim. Screening of previously isolated from R. chamaemorus individual compounds for the hemostasis system in vitro and identification of the most promising compounds for subsequent pharmaceutical development.Materials and methods. Experiments under in vitro conditions were performed on the blood of healthy male donors. The research of the effect on platelet aggregation was carried out according to the Born method on an AT-02 aggregometer (LLC "SPF "Medtech", Russia). Determination of anticoagulant activity was carried out by conventional clotting tests on a Solar CGL 2110 turbidimetric hemocoagulometer (CJSC "SOLAR", Russia). Cytofluorimetric analysis was performed on a NovoCyte instrument (Agilent Technologies, USA).Result and discussion. The influence of the isolated compounds 1–5 on the parameters of activation, platelet aggregation and the coagulation component of hemostasis was studied. At a concentration of 1.0 mg/ml, compounds 1–5 did not affect the fibrinogen concentration and prothrombin time. Compounds 1, 3 and 5 completely suppressed platelet activation at the studied concentrations. Compounds 1 and 3 showed antiaggregation activity comparible to the values of acetylsalicylic acid and are contained in all aqueous and alcoholic extracts of R. сhamaemorus leaves; their quantitative content varies depending on the extraction conditions.Conclusion. Thus, as a result of the screening of individual compounds 1–5 isolated from the leaves of R. chamaemorus their antiaggregating and anticoagulation properties were established. Compounds 1 (4-O-α-L-arabinofuranosylellagic acid) and 3 (quercetin-3-O-β-D-glucuronide) showed antiaggregation activity comparible to that of acetylsalicylic acid, and are the most promising of the studied series of compounds for the subsequent pharmaceutical development of new antiplatelet agents.
Aktualisasi Komisi Kepolisian Nasional Dalam Mewujudkan Reformasi Kepolisian Negara Republik Indonesia
Authors: Yusuf Yusuf , Harmoko Harmoko 
Published: February 2024

Penelitian ini mengkaji aktualisasi Kompolnas dalam mewujudkan reformasi Polri. Penelitian ini mencoba melihat aktualisasi Kompolnas dan tantangan yang dialami Kompolnas dalam melakukan reformasi kepolisian. Pendekatan yang digunakan dalam penelitian ini adalah hukum normatif. Bahan hukum yang dugunakan dalam penelitian ini adalah bahan hukum primer dan sekunder. Bahan hukum dikumpulkan secara sistematis melalui penelitian kepustakaan dan dokumentasi, kemudian bahan hukum tersebut dianalisis secara sistematis dengan menggunakan penalaran hukum deduktif dan induktif, dengan hasil analisis diuraikan dalam penelitian ini. Hasil penelitian ini mengungkapkan bahwa upaya Kompolnas dalam melaksanakan reformasi Polri belum maksimal karena tidak memiliki kewenangan hukum untuk mengevaluasi hasil rekomendasinya. Disamping itu masih ditemukan kendala yang dihadapi Kompolnas dalam mewujudkan reformasi Polri yakni fakto internal dan faktor eksternal.
Kata Kunci: Aktualisasi, Kompolnas, Reformasi, Polri
Is it True Perceived Fairness can Improve Employee Performance ?
Authors: Khotob Umar Bin , Marlien R.A. 
Published: February 2024

The performance of the State Civil Service Apparatus can be used as a benchmark to determine the qualifications and competence of government employees, as a measure of public trust in the government. The purpose of this study was to determine the effect of psychological capital and Person Organization Fit on performance by moderating perceptions of fairness at the Pati District Health Office. This research was conducted on employees at the Pati District Health Office with a population of 107 people. The sample takes the entire population to be used as a research sample. Data analysis used validity test with matrix components, reliability test with Cronbach alpha, multiple regression analysis, t test and r2 test with adjust r2 and moderation test. The results of the study concluded that psychological capital had a positive and significant effect on the performance of employees at the Pati District Health Office. Person Organization Fit has a positive and significant effect on employee performance at the Pati District Health Office. The perception of justice is considered unable to moderate the variables of psychological capital and Person Organization Fit on performance in the Pati District Health Office.
An Analysis of Dzikrayat Muslim Fashion Business Development Strategy With Canvas Business Model Approach In Ponorogo Regency, East Java
Authors: Zarkasy Muhammad Ridlo , Kurniawan Dhika Amalia , Zuhri Ahmad Syaifudin 
Published: February 2024

This research aims to develop a strategy for Dzikrayaat Muslim fashion business using a business model canvas (BMC). This used a descriptive qualitative method with SWOT analysis by samples of 4 stakeholder respondents and customers. The results show from a key partner perspective, Dzikrayaat needs to collaborate with brand ambassadors, Darussalam Gontor Boarding School graduates as new partners, agents, and distributors in marketing. From the perspective of key activities, the strategy can be done by adding product variations such as robes, headscarves, and other Muslim attributes. From the perspective of value proposition, adding the size of Muslim clothing is necessary. From the sector of customer relationships, it needs to give membership card and discount to loyal customers. For the customer segments, it adds a market of women or young mothers who are interested in Muslim fashion. From the key resources side, they have their cohesion and professional tailors. From the channels, it needs to start an online shop in the marketplace. From the perspective of revenue stream, it utilizes fabric waste for sale. Therefore, according to those results, researchers have some suggestions such as developing a strategy by adding some components to nine business blocks of the canvas model.
Deep learning denoising reconstruction for improved image quality in fetal cardiac cine MRI
Authors: Vollbrecht Thomas M. , Hart Christopher , Zhang Shuo , Katemann Christoph , Sprinkart Alois M. , Isaak Alexander , Attenberger Ulrike , Pieper Claus C. , Kuetting Daniel , Geipel Annegret , Strizek Brigitte , Luetkens Julian A. 
Published: February 2024

PurposeThis study aims to evaluate deep learning (DL) denoising reconstructions for image quality improvement of Doppler ultrasound (DUS)-gated fetal cardiac MRI in congenital heart disease (CHD).MethodsTwenty-five fetuses with CHD (mean gestational age: 35 ± 1 weeks) underwent fetal cardiac MRI at 3T. Cine imaging was acquired using a balanced steady-state free precession (bSSFP) sequence with Doppler ultrasound gating. Images were reconstructed using both compressed sensing (bSSFP CS) and a pre-trained convolutional neural network trained for DL denoising (bSSFP DL). Images were compared qualitatively based on a 5-point Likert scale (from 1 = non-diagnostic to 5 = excellent) and quantitatively by calculating the apparent signal-to-noise ratio (aSNR) and contrast-to-noise ratio (aCNR). Diagnostic confidence was assessed for the atria, ventricles, foramen ovale, valves, great vessels, aortic arch, and pulmonary veins.ResultsFetal cardiac cine MRI was successful in 23 fetuses (92%), with two studies excluded due to extensive fetal motion. The image quality of bSSFP DL cine reconstructions was rated superior to standard bSSFP CS cine images in terms of contrast [3 (interquartile range: 2–4) vs. 5 (4–5), P &lt; 0.001] and endocardial edge definition [3 (2–4) vs. 4 (4–5), P &lt; 0.001], while the extent of artifacts was found to be comparable [4 (3–4.75) vs. 4 (3–4), P = 0.40]. bSSFP DL images had higher aSNR and aCNR compared with the bSSFP CS images (aSNR: 13.4 ± 6.9 vs. 8.3 ± 3.6, P &lt; 0.001; aCNR: 26.6 ± 15.8 vs. 14.4 ± 6.8, P &lt; 0.001). Diagnostic confidence of the bSSFP DL images was superior for the evaluation of cardiovascular structures (e.g., atria and ventricles: P = 0.003).ConclusionDL image denoising provides superior quality for DUS-gated fetal cardiac cine imaging of CHD compared to standard CS image reconstruction.
Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease
Authors: Koppara Tobias , Dregely Isabel , Nekolla Stephan G. , Nährig Jörg , Langwieser Nicolas , Bradaric Christian , Ganter Carl , Laugwitz Karl-Ludwig , Schwaiger Markus , Ibrahim Tareq 
Published: February 2024

BackgroundSimultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a novel hybrid imaging method integrating the advances of morphological tissue characterization of MRI with the pathophysiological insights of PET applications.AimThis study evaluated the use of simultaneous 18-FDG PET/MR imaging for characterizing atherosclerotic lesions in lower extremity arterial disease (LEAD).MethodsEight patients with symptomatic stenoses of the superficial femoral artery (SFA) under simultaneous acquisition of 18-FDG PET and contrast-enhanced MRI using an integrated whole-body PET/MRI scanner. Invasive plaque characterization of the SFA was performed by intravascular imaging using optical coherence tomography. Histological analysis of plaque specimens was performed after directional atherectomy.ResultsMRI showed contrast enhancement at the site of arterial stenosis, as assessed on T2-w and T1-w images, compared to a control area of the contralateral SFA (0.38 ± 0.15 cm vs. 0.23 ± 0.11 cm; 1.77 ± 0.19 vs. 1.57 ± 0.15; p-value &lt;0.05). On PET imaging, uptake of 18F-FDG (target-to-background ratio TBR &gt; 1) at the level of symptomatic stenosis was observed in all but one patient. Contrast medium-induced MR signal enhancement was detected in all plaques, whereas FDG uptake in PET imaging was increased in lesions with active fibroatheroma and reduced in fibrocalcified lesions.ConclusionIn this multimodal imaging study, we report the feasibility and challenges of simultaneous PET/MR imaging of LEAD, which might offer new perspectives for risk estimation.
Autoimmune thyroid disease and myasthenia gravis: a study bidirectional Mendelian randomization
Authors: Wang Suijian , Wang Kui , Chen Xiaohong , Chen Daiyun , Lin Shaoda 
Published: February 2024

BackgroundPrevious studies have suggested a potential association between AITD and MG, but the evidence is limited and controversial, and the exact causal relationship remains uncertain.ObjectiveTherefore, we employed a Mendelian randomization (MR) analysis to investigate the causal relationship between AITD and MG.MethodsTo explore the interplay between AITD and MG, We conducted MR studies utilizing GWAS-based summary statistics in the European ancestry. Several techniques were used to ensure the stability of the causal effect, such as random-effect inverse variance weighted, weighted median, MR-Egger regression, and MR-PRESSO. Heterogeneity was evaluated by calculating Cochran’s Q value. Moreover, the presence of horizontal pleiotropy was investigated through MR-Egger regression and MR-PRESSOResultsThe IVW method indicates a causal relationship between both GD(OR 1.31,95%CI 1.08 to 1.60,P=0.005) and autoimmune hypothyroidism (OR: 1.26, 95% CI: 1.08 to 1.47, P =0.002) with MG. However, there is no association found between FT4(OR 0.88,95%CI 0.65 to 1.18,P=0.406), TPOAb(OR: 1.34, 95% CI: 0.86 to 2.07, P =0.186), TSH(OR: 0.97, 95% CI: 0.77 to 1.23, P =0.846), and MG. The reverse MR analysis reveals a causal relationship between MG and GD(OR: 1.50, 95% CI: 1.14 to 1.98, P =3.57e-3), with stable results. On the other hand, there is a significant association with autoimmune hypothyroidism(OR: 1.29, 95% CI: 1.04 to 1.59, P =0.019), but it is considered unstable due to the influence of horizontal pleiotropy (MR PRESSO Distortion Test P &lt; 0.001). MG has a higher prevalence of TPOAb(OR: 1.84, 95% CI: 1.39 to 2.42, P =1.47e-5) positivity and may be linked to elevated TSH levels(Beta:0.08,95% CI:0.01 to 0.14,P =0.011), while there is no correlation between MG and FT4(Beta:-9.03e-3,95% CI:-0.07 to 0.05,P =0.796).ConclusionAITD patients are more susceptible to developing MG, and MG patients also have a higher incidence of GD.
The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia
Authors: Bosco Giosiana , Di Giacomo Barbagallo Francesco , Di Marco Maurizio , Miano Nicoletta , Scilletta Sabrina , Spampinato Salvatore , Vitale Alessio , Di Bella Federica , Montalbano Maria , Di Mauro Stefania , Filippello Agnese , Scamporrino Alessandra , Milluzzo Agostino , Di Pino Antonino , Frittitta Lucia , Purrello Francesco , Piro Salvatore , Scicali Roberto 
Published: February 2024

Background and aimsFH women are less likely to receive intensive statin treatment and to obtain a 50% reduction of LDL-C from baseline compared to men with FH. SLCO1B1 rs4149056 might influence statin therapy compliance and thus LDL-C target achievement. Our aim was to evaluate the impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy (LLT) optimization in men and women with FH.MethodsThis was a retrospective observational study involving 412 FH subjects with a probable or defined clinical diagnosis of FH who had had genetic analysis from June 2016 to September 2022. Biochemical analysis was obtained from all subjects at baseline and at the last follow-up after LLT optimization.ResultsAfter LLT optimization the percentage of FH subjects on high-intensity statins decreased from the M/SLCO1B1- group to the W/SLCO1B1+ group and the same was found in LDL-C target distribution (for both p for trend &lt; 0.01). The prevalence of SASE fear increased from the M/SLCO1B1- group to the W/SLCO1B1+ group and the same was observed in reported myalgia distribution (for both p for trend &lt; 0.01). Logistic regression analysis showed that the W/SCLO1B1-, M/SCLO1B1+ and W/SCLO1B1+ groups were inversely associated with LDL-C target achievement (p for trend &lt; 0.001) and the W/SCLO1B1+ group exhibited the strongest association.ConclusionA low prevalence of FH women with SLCO1B1 rs4149056 were on high intensity statins and they rarely achieved LDL-C target. The genotype effect of SLCO1B1 rs4149056 could be more pronounced in FH women than men.