bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Ferroptosis-Elicited Inflammation Suppresses Hepatocellular Carcinoma Metastasis and Enhances Sorafenib Efficacy
Authors: Mu Ming , Huang Chun-Xiang , Qu Chuang , Li Pei-Lin , Wu Xiang-Ning , Yao Wudexin , Shen Chu , Huang Rucheng , Wan Chao-Chao , Jian Zhi-Wei , Zheng Limin , Wu Rui-Qi , Lao Xiang-Ming , Kuang Dong-Ming 
Published: January 2024

AbstractTriggering ferroptosis, an iron-dependent form of cell death, has recently emerged as an approach for treating cancer. A better understanding of the role and regulation of ferroptosis is needed to realize the potential of this therapeutic strategy. Here, we observed extensive activation of ferroptosis in hepatoma cells and human hepatocellular carcinoma (HCC) cases. Patients with low to moderate activation of ferroptosis in tumors had the highest risk of recurrence compared to patients with no or high ferroptosis. Upon encountering ferroptotic liver cancer cells, aggregated macrophages efficiently secreted proinflammatory IL1β to trigger neutrophil-mediated sinusoidal vascular remodeling, thereby creating favorable conditions for aggressive tumor growth and lung metastasis. Mechanistically, hyaluronan fragments released by cancer cells acted via an NF-κB–dependent pathway to upregulate IL1β precursors and the NLRP3 inflammasome in macrophages, and oxidized phospholipids secreted by ferroptotic cells activated the NLRP3 inflammasome to release functional IL1β. Depleting either macrophages or neutrophils or neutralizing IL1β in vivo effectively abrogated ferroptosis-mediated liver cancer growth and lung metastasis. More importantly, the ferroptosis-elicited inflammatory cellular network served as a negative feedback mechanism that led to therapeutic resistance to sorafenib in HCC. Targeting the ferroptosis-induced inflammatory axis significantly improved the therapeutic efficacy of sorafenib in vivo. Together, this study identified a role for ferroptosis in promoting HCC by triggering a macrophage/IL1β/neutrophil/vasculature axis.Significance:Ferroptosis induces a favorable tumor microenvironment and supports liver cancer progression by stimulating an inflammatory cellular network that can be targeted to suppress metastasis and improve the efficacy of sorafenib.
Textos, audiencias y medios de comunicación: La persistencia de las preguntas
Authors: Sandoval García Carlos 
Published: January 2024

Este artículo se interroga por cambios y permanencias en los modos en que se analizan los vínculos entre medios de comunicación, poder y sociedad a propósito de los ecosistemas comunicativos hoy llamados tradicionales, como la prensa, la radio y la televisión, y las plataformas digitales que se han consolidado en el siglo XXI. En particular se presta atención a tres perspectivas: la capacidad de los discursos para interpelar a audiencias, la actividad de las audiencias y el papel de las industrias comunicacionales. La investigación académica sobre los vínculos entre medios, poder y sociedad requiere reparar los cambios entre lo “tradicional” y lo “nuevo”, y las permanencias. Asimismo, se sugiere una apropiación crítica de las trayectorias de investigación de estos vínculos, para que no se reproduzcan algunos de los “callejones sin salida” transitados décadas atrás.
Enfatizar en la persistencia de las preguntas sugiere que los entornos mediáticos tradicionales y nuevos se representan usualmente como separados, como una suerte de un “antes” y un “después”, y ello se expresa también en las formas de análisis que, con frecuencia, se llevan adelante. En contraste, este ensayo subraya que la investigación académica acerca de los vínculos entre medios, poder y sociedad requiere reparar no solo en los cambios entre lo “tradicional” y lo “nuevo”, sino también en las permanencias. Asimismo, sugiere una apropiación crítica de las trayectorias de investigación de estos vínculos, de modo que no se reproduzcan algunos de los “callejones sin salida” transitados décadas atrás.
Cruces y límites en la investigación sobre comunicación: El sentido práctico interdisciplinar
Authors: León-Duarte Gustavo Adolfo 
Published: January 2024

Este texto trabaja el argumento de que muchos de los desafíos contemporáneos de la investigación sobre comunicación obedecen a desafíos propiamente interdisciplinarios, a la vez que advierte distintas provocaciones epistemológicas de la investigación interdisciplinaria como retos de la comunicación especializada. Reflexiona sobre la investigación en comunicación, y posibles dominios de conocimiento aplicado a su práctica normativa, en torno a lo cual se pueden anclar una serie de preguntas de comunicación sin perder lo que varios estudiosos han llamado su naturaleza y estatuto (inter)disciplinar.
Internacionalización y raíces identitarias de la comunicación en Argentina
Authors: Cicalese Gabriela Rosa 
Published: January 2024

Este artículo pone en cuestión si los procesos de internacionalización institucionalizados por los circuitos de la industria académica redundaron en una mayor diversidad de procedencias de textos significativos y referentes en la formación de comunicadores en Argentina. También se rescatan las huellas de internacionalización que derivan de los trayectos y las voces de protagonistas de las carreras de Comunicación en Universidades públicas argentinas, desde las raíces constitutivas del campo, cuando aún la internacionalización no estaba institucionalizada entre la oferta académica de las universidades ni regulada por las Comisiones evaluadoras del Ministerio de Educación y las líneas de investigación dependientes del Estado Nacional.
También se rescatan las huellas de internacionalización que derivan de los trayectos y las voces de protagonistas de las carreras de Comunicación en Universidades públicas argentinas, cuando aún la internacionalización no estaba institucionalizada entre la oferta académica de las universidades ni regulada por las Comisiones evaluadoras del Ministerio de Educación y las líneas de investigación dependientes del Estado Nacional. Intentamos mostrar la impronta internacional que apareció desde las raíces constitutivas del campo. Y, a la vez, plantear una serie de interpelaciones respecto de la naturalización actual de los programas de internacionalización en las unidades académicas de las Universidades Públicas y en las carreras de Comunicación.
Accelerated diffusion-weighted magnetic resonance imaging at 7 T: Joint reconstruction for shift-encoded navigator-based interleaved echo planar imaging (JETS-NAViEPI)
Authors: Tan Zhengguo , Liebig Patrick Alexander , Heidemann Robin Martin , Laun Frederik Bernd , Knoll Florian 
Published: January 2024

Abstract
The pursuit of high spatial-angular-temporal resolution for in vivo diffusion-weighted magnetic resonance imaging (DW-MRI) at ultra-high field strength (7 T and above) is important in understanding brain microstructure and function. Such pursuit, however, faces several technical challenges. First, increased off-resonance and shorter T2 relaxation require faster echo train readouts. Second, existing high-resolution DW-MRI techniques usually employ in-plane fully-sampled multi-shot EPI, which not only prolongs the scan time but also induces a high specific absorption rate (SAR) at 7 T. To address these challenges, we develop in this work navigator-based interleaved EPI (NAViEPI) which enforces the same effective echo spacing (ESP) between the imaging and the navigator echo. First, NAViEPI renders no distortion mismatch between the two echoes, and thus simplifies shot-to-shot phase variation correction. Second, NAViEPI allows for a large number of shots (e.g., &gt;4) with undersampled iEPI acquisition, thereby rendering clinically-feasible high-resolution sub-milliemeter protocols. To retain signal-to-noise ratio (SNR) and to reduce undersampling artifacts, we developed a ky-shift encoding among diffusion encodings to explore complementary k- q-space sampling. Moreover, we developed a novel joint reconstruction with overlapping locally low-rank regularization generalized to the multi-band multi-shot acquisition at 7 T (dubbed JETS-NAViEPI). Our method was demonstrated, with experimental results covering 1 mm isotropic resolution multi b-value DWI and sub-millimeter in-plane resolution fast TRACE acquisition.
The Acquisition of Inalienable Possession in L2 and Heritage Spanish
Authors: Solano-Escobar Laura , Cuza Alejandro 
Published: January 2024

Abstract
The present study examines the production and interpretation of inalienable possession in dative constructions with body-part nouns in Spanish by 25 English-speaking L2 learners and 25 heritage speakers of Spanish born and raised in the United States. Twenty Spanish-dominant speakers served as baseline group. The results showed significant divergencies with inalienable NPs among the L2 learners compared to the heritage speakers and Spanish-dominant speakers. The L2 learners produced few instances of clitic se and a definite determiner and favored the use of a possessive determiner with or without a clitic instead. The heritage speakers and baseline group behaved similarly in their use of a clitic and a definite determiner. We argue for age of onset of acquisition and crosslinguistic influence effects in the acquisition of inalienable possession in Spanish.
The correlation of non-invasive hemoglobin testing and lab hemoglobin in surgical patients: A systematic review and meta-analysis
Authors: Kazma Jamil , Ebner Megan , Slota James , Berger Jeffery S. , Farooq Fouzia , Smith Emily , Ahmadzia Homa K. 
Published: January 2024

Background The decision regarding intraoperative transfusion has traditionally been based on hemodynamic instability and estimated blood loss. We performed a systematic review to determine the validity of the oximetry method compared to standard of care for hemoglobin measurement. Methods A systematic literature review was conducted, and several libraries were searched from inception to March 31,2023. The primary outcome was comparing the mean difference between laboratory-derived hemoglobin and non-invasive, point-of-care hemoglobin measurement. Subgroup analysis included comparing the mean difference in the pediatric population and among female patients. Results A total of 276 studies were identified, and 37 were included. We found that the pooled mean difference varied qualitatively between adult and pediatric population ( p value for heterogeneity <0.001). In adult populations, lab hemoglobin measurements were on average slightly higher than non-invasive measurements (mean difference = 0.23; 95% CI -0.13, 0.59), though there was greater heterogeneity across studies (I2 = 97%, p value = <0.001). In the pediatric population, most studies showed lab hemoglobin to be slightly lower (mean difference = −0.42; 95% CI -0.87 to 0.03). Conclusions In general, there was no clinically significant difference in mean hemoglobin among adult and pediatric populations. The percentage of female participants had no effect on the mean difference in hemoglobin.
A multiplex recombinase polymerase amplification assay combined with CRISPR/Cas12a for the detection of respiratory syncytial virus and respiratory adenovirus
Authors: Hongdan Gao , Yao Du , Qiang Chai , Meng Huang , Xiaorong Liu , Zhihao Xing , Dongli Ma 
Published: January 2024

Objective Respiratory syncytial virus (RSV) and respiratory adenovirus (ADV) are two common pathogens that cause acute respiratory tract infections in children. We aimed to develop a rapid method for detecting both pathogens simultaneously. Methods The recombinase polymerase isothermal amplification (RPA) method was combined with the CRISPR/Cas detection system. The assay’s specificity and sensitivity were explored by designing RPA primers and CRISPR RNAs (crRNAs) through multi-sequence comparisons, optimizing the reaction conditions, and using a fluorescent reading device. The consistency of the test results of 160 clinical pharyngeal swab samples was studied using quantitative polymerase chain reaction (qPCR) results as a comparative control. Results RSV and ADV could be detected at levels as low as 104 copies/mL and 103 copies/mL, respectively, within 50 minutes with no cross-reactivity with other similar pathogens. For the clinical samples, compared with the qPCR method, the sensitivities for RSV and ADV were 98.1% and 91.4%, respectively, and the detection specificities were both 100%. The Kappa values were greater than 0.95, suggesting a high degree of consistency. Conclusion This method for detecting RSV and ADV is rapid, sensitive, and specific. It can accurately detect mixed infections in a timely manner, making it suitable for use in areas with scarce healthcare resources.
ASES and UCLA Are Responsive Patient-Reported Outcome Measures After Rotator Cuff Repair: A Systematic Review and Meta-analysis
Authors: Abed Varag , Kapp Sabryn , Nichols Michael , Brunty Nathan , Conley Caitlin E.W. , Jacobs Cale A. , Robinson Lauren E. , Stone Austin V. 
Published: January 2024

Background: Multiple patient-reported outcome measures (PROMs) have been used to assess shoulder function, but it is unknown which are the most effective. Purpose/Hypothesis: The purpose of this study was to report the multiple PROMs used after rotator cuff repair (RCR) and to compare the responsiveness between them. It was hypothesized that the Western Ontario Rotator Cuff PROM would be the most responsive and commonly used in patients undergoing RCR. Study Design: Meta-analysis; Level of evidence, 4. Methods: A systematic review was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and PRISMA-Searching extension guidelines via PubMed/MEDLINE, Embase (Elsevier), and Web of Science (Clarivate). Patient and study characteristics were extracted. From the studies that met inclusion criteria for responsiveness analysis (≥2 PROMs reported, 1-year minimum follow-up, and pre- and postoperative PROM means and standard deviations reported), the authors compared the responsiveness between PROM instruments using effect size and relative efficiency (RE) if a PROM could be compared with another in ≥10 articles. Results: A total of 252 studies met inclusion criteria (32,072 patients; mean age, 59.6 years; mean body mass index, 28.7; mean follow-up time, 27.8 months). Range of motion was reported in 131 (52%) studies and imaging findings were reported in 123 (49%) studies. There were 67 PROM instruments identified; the most commonly used were the American Shoulder and Elbow Surgeon (ASES) (n = 183; 73%), Visual Analog Scale (VAS) (n = 163; 65%), and Constant (n = 118; 47%) scores. The 3 PROMs with the highest effect sizes were the University of California, Los Angeles (UCLA) (2.51), Western Ontario Rotator Cuff (2.42), and ASES (2.00) scores. Overall, UCLA and ASES scores were the most responsive PROMs. The ASES PROM was more responsive than the VAS (RE, 1.70), Constant (RE, 2.76), Simple Shoulder Test (RE, 1.67), and Single Assessment Numeric Evaluation (RE, 2.14) scores. The UCLA PROM was more responsive than the ASES (RE, 1.03), VAS (RE, 3.66), Constant (RE, 1.72), and Simple Shoulder Test (RE, 1.66) scores. Conclusion: ASES and UCLA scores were the most responsive PROMs after RCR. The authors recommend widespread adoption of ASES and UCLA scores for clinical and research standardization; however, the UCLA PROM requires in-person range of motion and strength testing, which is a practical limitation and barrier to long-term follow-up.
Costal Chondrocyte–Derived Pellet-Type Autologous Chondrocyte Implantation Versus Microfracture for the Treatment of Articular Cartilage Defects: A 5-Year Follow-up of a Prospective Randomized Trial
Authors: Yoon Kyoung-Ho , Lee Jungsun , Park Jae-Young 
Published: January 2024

Background: Costal chondrocyte–derived pellet-type autologous chondrocyte implantation (CCP-ACI) has been introduced as a new therapeutic option for the treatment of articular cartilage defects. We had previously conducted a randomized controlled trial comparing CCP-ACI versus microfracture at 1 year postoperatively. Purpose: To compare the efficacy and safety of CCP-ACI versus microfracture for the treatment of articular cartilage defects of the knee at 5 years postoperatively. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: This study describes the mean 5-year follow-up of a previously published prospective clinical trial. The previous prospective trial compared the results of CCP-ACI versus microfracture until 1 year of follow-up. Of the 30 patients who were included in the previous study, 25 were followed up for 5 years. Patients were evaluated based on clinical outcome scores (Lysholm score, International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score [KOOS], and visual analog scale for pain), magnetic resonance imaging findings, and rates of treatment failure at last follow-up. Results: The MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) score in the CCP-ACI group was significantly higher than that in the microfracture group at 5 years (62.3 vs 26.7, respectively; P < .0001). The Lysholm score and KOOS score in the CCP-ACI group were significantly higher than those in the microfracture group at 5 years (84.5 vs 64.9, respectively, and 390.9 vs 303.0, respectively; P = .023 and P = .017, respectively). There was 1 case of treatment failure that occurred in the microfracture group. Conclusion: The present randomized controlled trial indicated that the results of both procedures clinically and statistically significantly improved at 1 and 5 years’ follow-up in treating cartilage defects, but the results of CCP-ACI were superior to those of microfracture. Magnetic resonance imaging conducted at 1 year and 5 years after CCP-ACI revealed statistically significant superior structural integration with native cartilage tissue compared with microfracture. Registration: NCT03545269 (ClinicalTrials.gov)
Associations Between Gut Microbial Features and Sickness Symptoms in Kidney Transplant Recipients
Authors: Sung Choa , Park Chang Gi , Maienschein-Cline Mark , Chlipala George , Green Stefan , Doorenbos Ardith , Fink Anne , Bronas Ulf , Lockwood Mark 
Published: January 2024

Purpose The study investigated the relationship of gut microbiome features and sickness symptoms in kidney transplant recipients. Methods Employing a prospective, longitudinal design, we collected data from 19 participants who had undergone living-donor kidney transplant at three timepoints (pre-transplant and 1 week and 3 months post-transplant). Sickness symptom data and fecal specimens were collected at each timepoint. Participants were grouped either as high or low sickness symptom severity at baseline. Shotgun metagenomics sequencing characterized gut microbial structure and functional gene content. Fecal microbial features, including alpha (evenness and richness within samples) and beta (dissimilarities between samples) diversity and relative abundances, were analyzed using R statistical packages. Cross-sectional and longitudinal analyses examined relationships between gut microbial features and sickness symptoms. Results Although our exploratory findings revealed no significant differences in alpha and beta diversity between groups, the high-severity group showed lower microbial richness and evenness than the low-severity group. The high-severity group had enriched relative abundance of bacteria from the genera Citrobacter and Enterobacter and reduced relative abundance of bacteria from the genus Akkermansia across timepoints. No functional genes differed significantly between groups or timepoints. Conclusions Kidney transplant recipients with high symptom burden displayed increased putative proinflammatory bacteria and decreased beneficial bacteria. This study provides an effect size that future large cohort studies can employ to confirm associations between gut microbial features and sickness symptom experiences in the kidney transplant population. The study findings also have implications for future interventional studies aiming to alleviate the sickness symptom burden in this population.
Exploring the relationship between sleep and aggression in adolescents: A cross sectional study using the UK Millennium cohort study
Authors: McCaffrey Caoimhe , McClure John , Singh Sukhmeet , Melville Craig A 
Published: January 2024

This study aimed to establish if a significant relationship exists between sleep and aggression in a large representative adolescent cohort and explores the impact of potential confounders. This cross-sectional secondary data analysis included 10,866 males and females aged 13–15 years, from the UK-based 2015 Millenium Cohort Study (sixth sweep). Independent variables included self-report measures of sleep duration and quality. The parent reported ‘Strengths and Difficulties Questionnaire’ conduct score measured aggression. Binary logistic regression examined independent associations between each sleep variable and aggression. Multiple regression models then adjusted for potential confounders: age, sex, socioeconomic status, arousal, and affect. Under 8 hours of sleep on average was significantly associated with aggression when age, sex and income were controlled ( p = .008). This became insignificant following adjustment for both affect and arousal. Sleep quality remained significantly associated with aggression when all confounders were controlled: ‘sleep onset latency >30 minutes’ and ‘wakening at least a good bit of the time’ increased the odds of aggression by around 27.9% ( p < .001) and 43.5% respectively ( p < .001). A significant association exists between poor subjective sleep quality and heightened aggression in this cohort, when all our confounders are controlled, identifying sleep quality as a potential target in treating adolescent aggression.
Mixed language in flux? The various impacts of multilingual contact on Lánnang-uè’s wh-question system
Authors: Gonzales Wilkinson Daniel Wong 
Published: January 2024

Aims and objectives: What exactly happens to a mixed language’s system in a multilingual contact setting? This study aims to investigate the interactions between speakers’ exposure to, frequency of, and proficiency in four languages (English, Tagalog, Hokkien, and Mandarin) and their influences on the why-fronting only wh-question system of Lánnang-uè, a mixed language used by the metropolitan Manila Lannangs. It also aims to test the validity of the assertion that symbiotic mixed languages are more likely to be in flux. Methodology: The Lánnang-uè speakers participated in production and acceptability experiments. Data analysis: Likelihood to front (production) and responses to a 7-point Likert-type scale (acceptability) were the dependent variables for several Bayesian linear mixed-effects models with age, frequency of language use, and language proficiency as primary fixed effects, sociolinguistic factors (e.g., attitudes, identity) as covariates, and participant (and when appropriate, item) as a random effect. Findings: Both production and acceptability results showed that the effects of contact are numerous and far from homogeneous. They vary depending on the source language, wh-phrase type, and degree of consciousness. They corroborate the widely held belief that mixed languages are less stable in symbiotic contexts. However, this paper goes an extra step to show that this “instability” or variability is not always a consequence of contact-induced transfer. It demonstrates that when the source languages influence the stability or development of the mixed language, the effects can be diverse, encompassing aspects such as identity processes, language attitudes, structural transfer, and/or other sociolinguistic innovations. Originality: This article is one of the first studies to examine the effects of contact between multiple languages on a mixed language variable using both production and acceptability experimental data in a five-language context. It is one of the very few variationist works in the Philippines that considers the effects of multilingualism on variation and change.