bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor microbiome analysis provides prognostic value for patients with stage III colorectal cancer
Authors: Kim Jae Hyun , Yu Jongwook , Kim Dong Keon , Lee Seunghun , Lee Seung Hyun , Ahn Byung Kwon , Kim Tae Il , Park Seun Ja 
Published: October 2023

IntroductionAlthough patients with colorectal cancer (CRC) can receive optimal treatment, the risk of recurrence remains. This study aimed to evaluate whether the tumor microbiome can be a predictor of recurrence in patients with stage III CRC.MethodsUsing 16S rRNA gene sequencing, we analyzed the microbiomes of tumor and adjacent tissues acquired during surgery in 65 patients with stage III CRC and evaluated the correlation of the tissue microbiome with CRC recurrence. Additionally, the tumor tissue microbiome data of 71 patients with stage III CRC from another center were used as a validation set.ResultsThe microbial diversity and abundance significantly differed between tumor and adjacent tissues. In particular, Streptococcus and Gemella were more abundant in tumor tissue samples than in adjacent tissue samples. The microbial diversity and abundance in tumor and adjacent tissues did not differ according to the presence of recurrence, except for one genus in the validation set. Logistic regression analysis revealed that a recurrence prediction model including tumor tissue microbiome data had a better prediction performance than clinical factors (area under the curve [AUC] 0.846 vs. 0.679, p = 0.009), regardless of sex (male patients: AUC 0.943 vs. 0.818, p = 0.043; female patients: AUC 0.885 vs. 0.590, p = 0.017). When this prediction model was applied to the validation set, it had a higher AUC value than clinical factors in female patients.ConclusionOur results suggest that the tumor microbiome of patients with CRC be a potential predictor of postoperative disease recurrence.
Assessing real-world implementability of a multimodal group-based tele-prehabilitation program in cancer care: a pragmatic feasibility study
Authors: Piché Alexia , Santa Mina Daniel , Lambert Sylvie , Doré Isabelle 
Published: October 2023

IntroductionMultimodal prehabilitation is intended to optimize a patient’s mental and physical health prior to surgery. Most multimodal prehabilitation interventions are delivered on a one-on-one format, which may limit benefits associated with social interactions that can be achieved in a group context, and are delivered in-person, which may limit the accessibility. The purpose of this study was to develop a group-based, multimodal, tele-prehabilitation intervention for individuals diagnosed with cancer (iACTIF) and assess its implementability in a “real-world” clinical setting by measuring feasibility, acceptability, fidelity, and preliminary effects. MethodsA prospective, single-group, pragmatic feasibility study was conducted with assessments at baseline, pre-surgery, and 12-weeks post-surgery. iACTIF consisted of three 90-min live videoconference sessions per week, including exercise and educational components. Descriptive statistics were used to document feasibility, acceptability, and fidelity indicators. Paired t-test, Wilcoxon test, and Cohen’s D-test were conducted to assess changes in health-related outcomes.ResultsA total of 25 participants (mean age ± SD= 60.2 ± 14.0) were recruited. The feasibility assessment revealed a low referral rate (31.4%) and a high study retention (98%) and program attendance [session attended/possible session] (70.2%), with a prehabilitation window of 32.7 days (SD= 20.9, median= 28). Acceptability was high (84%–100%) according to satisfaction, utility and safety, delivery modality, and intention to continue physical activity and to recommend iACTIF to a relative. Pre–post-intervention assessments suggest positive changes on physical functional capacity based on the 2-min step test (mean difference= +18.9 steps, p=0.005), the 30-s sit-to-stand (mean difference= +1.1 repetition, p=0.011), and volume of moderate intensity physical activity per week (mean difference= +104.8 min, p&lt;0.001). Fidelity was supported by conformity and coherence, with only minimal adjustments required to meet participants’ needs.DiscussioniACTIF implementability in a “real-world” clinical setting is promising, and preliminary outcomes suggest moderate benefits on physical health and small increase in mental health indicators.
The role of life satisfaction and living arrangements in the association between chronic disease and depression: a national cross-sectional survey
Authors: Shang Zhao , Liu Yuqing , Xue Dongyu , Zheng Yiping , Li Yueping , Zhang Baoquan , Dai Yue 
Published: October 2023

IntroductionFor middle-aged and older people, depression is a frequent and prevalent illness. The purpose of this study was to examine the moderating function of living arrangements in the mediating model as well as the mediating role of life satisfaction in the association between chronic diseases and depressive symptoms.MethodsThe China Health and Retirement Longitudinal Study (CHARLS) provided the data for this investigation (2018). Respondents were grouped according to depression status to compare the differences between middle-aged and older people with different depression statuses. The moderating effect of living arrangements and the mediating effect of life satisfaction were tested using the Bootstrap program and the simple slope approach.ResultsThe population’s total prevalence of depressive symptoms was 30.3%. According to the mediating effect research, middle-aged and older people with chronic diseases experienced substantial direct effects on depressive symptoms (β = 1.011, p &lt; 0.001). It has been established that life satisfaction has an 18.6% mediation effect between depressive symptoms and chronic diseases. Regarding the further moderating influence, it was discovered that chronic diseases had a more significant impact on the life satisfaction of middle-aged and older people who are in live alone than those who are living with others (β = 0.037, p &lt; 0.05).ConclusionIn middle-aged and older people, chronic diseases have a major influence on depressive symptoms. Life satisfaction mediated the relationship between chronic diseases and depressive symptoms, and living arrangements moderated the first part of the route in the mediation model. Therefore, life satisfaction and living arrangements should be important considerations to decrease the prevalence of depressive symptoms in middle-aged and older people.
The mediating role of attachment and anger: exploring the impact of maternal early-life maltreatment on child abuse potential
Authors: Wuebken Karolina , Bermpohl Felix , Boedeker Katja , Hindi Attar Catherine , Kluczniok Dorothea , Schoofs Nikola , Fuchs Anna , Neukel Corinne , Herpertz Sabine C. , Brunner Romuald , Winter Sibylle Maria , Kaess Michael , Jaite Charlotte , Dittrich Katja 
Published: October 2023

BackgroundMaternal early-life maltreatment (ELM) increases the risk of subsequent child maltreatment, but the underlying mechanisms of these intergenerational effects remain largely unknown. Identifying these mechanisms is crucial for developing preventive interventions that can break the cycle of abuse. Notably, previous research has shown that ELM often results in attachment insecurity and altered anger characteristics. Therefore, this study determines whether these characteristics mediate the relationship between maternal history of ELM and child abuse potential.MethodsThe study sample included 254 mothers, of whom 149 had experienced ELM to at least a moderate degree. Maternal ELM was assessed using the Childhood Experience of Care and Abuse (CECA) interview. Attachment insecurity, trait anger and anger expression, and maternal abuse potential were assessed using the Vulnerable Attachment Questionnaire (VASQ), State–Trait Anger Expression Inventory (STAXI), and Child Abuse Potential Inventory (CAPI), respectively.ResultsThe severity of maternal ELM predicted higher child abuse potential, with attachment insecurity and anger suppression mediating this effect. Specifically, higher levels of maternal ELM were associated with greater attachment insecurity and increased anger suppression, resulting in a higher child abuse potential. Although higher levels of trait anger were directly associated with higher child abuse potential, this parameter did not mediate the relationship with ELM. In addition, no significant associations were observed between outwardly expressed anger and ELM or child abuse potential. All analyses were adjusted for maternal mental disorders, years of education, and relationship status.DiscussionAttachment insecurity and anger suppression may serve as pathways linking the maternal history of ELM to the risk of child abuse, even when considering maternal psychopathology. Overall, our findings indicate that interventions aimed at strengthening attachment and improving anger suppression may be beneficial for all mothers with ELM history and high child abuse potential, not just those who suffer from mental illness.
Genomic characterization of SARS-CoV-2 from an indigenous reserve in Mato Grosso do Sul, Brazil
Authors: de Oliveira Laís Albuquerque , de Rezende Izabela Mauricio , Navarini Vinicius João , Marchioro Silvana Beutinger , Torres Alex José Leite , Croda Julio , Croda Mariana Garcia , Gonçalves Crhistinne Cavalheiro Maymone , Xavier Joilson , de Castro Emerson , Lima Mauricio , Iani Felipe , Adelino Talita , Aburjaile Flávia , Ferraz Demarchi Luiz Henrique , Taira Deborah Ledesma , Zardin Marina Castilhos Souza Umaki , Fonseca Vagner , Giovanetti Marta , Andrews Jason , Alcantara Luiz Carlos Junior , Simionatto Simone 
Published: October 2023

BackgroundThe COVID-19 pandemic had a major impact on indigenous populations. Understanding the viral dynamics within this population is essential to create targeted protection measures.MethodsA total of 204 SARS-CoV-2 positive samples collected between May 2020 and November 2021 from an indigenous area in Mato Grosso do Sul (MS), Midwestern Brazil, were screened. Samples were submitted to whole genome sequencing using the Nanopore sequencing platform. Clinical, demographic, and phylogenetic data were analyzed.ResultsWe found the co-circulation of six main SARS-CoV-2 lineages in the indigenous population, with the Zeta lineage being the most prevalent (27.66%), followed by B.1.1 (an ancestral strain) (20.21%), Gamma (14.36%) and Delta (13.83%). Other lineages represent 45.74% of the total. Our phylogenetic reconstruction indicates that multiple introduction events of different SARS-CoV-2 lineages occurred in the indigenous villages in MS. The estimated indigenous population mortality rate was 1.47%. Regarding the ethnicity of our cohort, 64.82% belong to the Guarani ethnicity, while 33.16% belong to the Terena ethnicity, with a slightly higher prevalence of males (53.43%) among females. Other ethnicities represent 2.01%. We also observed that almost all patients (89.55%) presented signs and symptoms related to COVID-19, being the most prevalent cough, fever, sore throat, and headache.DiscussionOur results revealed that multiple independent SARS-CoV-2 introduction events had occurred through time, probably due to indigenous mobility, since the villages studied here are close to urban areas in MS. The mortality rate was slightly below of the estimation for the state in the period studied, which we believe could be related to the small number of samples evaluated, the underreporting of cases and deaths among this population, and the inconsistency of secondary data available for this study.ConclusionIn this study, we showed the circulation of multiple SARS-CoV-2 variants in this population, which should be isolated and protected as they belong to the most fragile group due to their socioeconomic and cultural disparities. We reinforce the need for constant genomic surveillance to monitor and prevent the spread of new emerging viruses and to better understand the viral dynamics in these populations, making it possible to direct specific actions.
Sick child’s feeding practices and associated factors among mothers with sick children aged less than 2 years in Gamo zone, southern Ethiopia. Does the participation of fathers contribute to improving nutrition? A facility-based cross-sectional study
Authors: Hailu Feven Masresha , Kefene Simegn Wagaye , Sorrie Muluken Bekele , Mekuria Misgun Shewangezaw , Guyo Tamirat Gezahegn 
Published: October 2023

BackgroundChildren’s nutritional status can decline rapidly during or after a common childhood illness unless additional nutritional requirements associated with the illness are considered. Therefore, this study was aimed at assessing a sick child’s feeding practices and associated factors among mothers who have sick children under 2 years of age in southern Ethiopia.MethodsA facility-based cross-sectional study design was employed from 1 April 2022 to 30 April 2022. Data were collected through the questionnaire, entered into an open data kit (ODK), and exported into Statistical Packages for Social Sciences (SPSS) version 25.0 for analysis. A systematic random sampling technique was used to select study participants. Bivariable and multivariable logistic regression analyses were used to identify factors associated with sick child feeding practices. An adjusted odds ratio (AOR) with 95% confidence intervals (CIs) was used to determine the strength of the association. Statistical significance was declared at a p-value of &lt;0.05.ResultsThe overall magnitude of mothers’ good sick child feeding practices was determined to be 45.0% (95% CI: 41.03, 48.97%). Being urban residents, being employed, having antenatal care (ANC) visits, having postnatal care (PNC) visits, counseling about child feeding, and fathers’ involvement in sick child feeding increased the likelihood of sick child feeding practices by 4.4, 2.10, 2.31, 3.54, 2.11, and 2.54 times, respectively.ConclusionSick child feeding practices were associated with having antenatal or postnatal visits, counseling about child feeding, and fathers’ involvement in sick child feeding practices. Therefore, strengthening infant and young child feeding practices by showing special concern for the father’s involvement is important to improve mothers’ sick child feeding practices.
Therapeutic Approach Targeting Gut Microbiome in Gastrointestinal Infectious Diseases
Authors: Han Ziying , Min Yiyang , Pang Ke , Wu Dong 
Published: October 2023

While emerging evidence highlights the significance of gut microbiome in gastrointestinal infectious diseases, treatments like Fecal Microbiota Transplantation (FMT) and probiotics are gaining popularity, especially for diarrhea patients. However, the specific role of the gut microbiome in different gastrointestinal infectious diseases remains uncertain. There is no consensus on whether gut modulation therapy is universally effective for all such infections. In this comprehensive review, we examine recent developments of the gut microbiome’s involvement in several gastrointestinal infectious diseases, including infection of Helicobacter pylori, Clostridium difficile, Vibrio cholerae, enteric viruses, Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa Staphylococcus aureus, Candida albicans, and Giardia duodenalis. We have also incorporated information about fungi and engineered bacteria in gastrointestinal infectious diseases, aiming for a more comprehensive overview of the role of the gut microbiome. This review will provide insights into the pathogenic mechanisms of the gut microbiome while exploring the microbiome’s potential in the prevention, diagnosis, prediction, and treatment of gastrointestinal infections.
STUDENTS’ SCIENTIFIC RESEARCH ACTIVITIES ORGANIZATION IN DESIGN AND PLANNING
Authors: Borysova T. , Usenko O. , Ihnatenko M. 
Published: October 2023

In our research, the main attention is paid to the peculiarities of scientific research activities organization of students of various creative specialties, both standardized by curricula and educational programs of future specialist professional training, and voluntary during extracurricular time. The characteristic features of students’ mandatory (standardized) scientific research activity, which is related to the performance of coursework and qualification diploma theses, have been determined. We have also revealed a number of methods and means of voluntary, but motivated or interested involvement of student youth in scientific research activities through the performance of scientific, technical and project tasks by students during the period of industrial practices, participation in the work of educational and scientific laboratories, student design bureaus, design workshops associations and creative unions, fulfillment of production orders.
Carrying out research projects encourages students to study and use innovative solutions, technologies, equipment, etc. In this way, the relationship between students’ scientific research and innovative activity in the process of professional training of future specialists in creative specialties is proven; in particular, examples of future engineers’ experimental scientific research activity and future designers’ project-technological artistic and creative scientific work are given.
In the process of scientific research, the essence and significance of research and innovation activities of students of creative specialties have been determined for future specialists’ professional self-development and the formation of personal qualities, competencies, knowledge, abilities and skills in certain fields of knowledge.
Forms of pedagogical guidance of students’ scientific research and innovative activities, methods and means of involving students to participate in scientific and practical conferences, round tables, exhibitions, professional competitions, as well as publication of the results of scientific research work in collections of student scientific works and catalogs of creative works are outlined.
CONTENT OF NATURAL AND SCIENTIFIC TRAINING OF FUTURE SPECIALISTS IN PHYSICAL THERAPY AND ERGOTHERAPY AT THE INITIAL (THEORETICAL) STAGE OF TRAINING
Authors: Fastivet A. 
Published: October 2023

The article examines the regulatory and legal provision of natural and scientific training for future specialists in physical therapy and ergotherapy in modern higher education institutions. A structural analysis of the content of natural and scientific training of future specialists in physical therapy and ergotherapy at the initial (theoretical) stage of training has been carried out. A systematic study of the educational disciplines of the natural and scientific training of future specialists in physical therapy and ergotherapy makes it possible to reveal their significant number, the presence of frequent repetitions of the same type of information and situational tasks, that is, the task of mutual coordination of the content component of training, modernization of natural and scientific training and optimization based on structural analysis. The results of the structural analysis of the content of natural and scientific training of future specialists in physical therapy and ergotherapy at the initial (theoretical) stage of training are given.
The professionally oriented content of natural science disciplines («Biochemistry», «Human Anatomy», «Human Physiology», «Age Anatomy and Physiology», «Physiology of Motor Activity», «Fundamentals of Hygiene and Ecology», «Biomechanics», «General Theory of Health, Diagnosis and Monitoring of the State of Health»), and their focus on the formation of the components of the natural and scientific competence of a specialist in physical therapy and ergotherapy is determined.
The organization of natural and scientific training through the implementation of the methodology for the formation of professional competence of future specialists in physical therapy and ergotherapy integrates practice-oriented teaching techniques and is aimed at defined pedagogical conditions implementation. It is worth noting that in the process of natural and scientific training, the specified pedagogical conditions are implemented based on taking into account the peculiarities of the functioning of the integral integration system and by introducing the initial (theoretical), basic (practically oriented) and final (professionally adaptive) stages of training.
Tensions pédagogiques et identitaires des professeurs débutants en ZEP
Authors: Périer Pierre 
Published: October 2023

Les professeurs qui débutent en collège en ZEP sont surtout confrontés à la gestion d’une instabilité chronique dans la relation avec leurs élèves. Ils sont peu préparés aux situations imprévisibles qui constituent désormais leur quotidien. En but à des tensions contradictoires entre leur souci d’aider les plus faibles et le sentiment d’oublier les plus forts, ils doivent puiser dans leurs ressources personnelles, inventer tactiques et stratégies d’accommodation pour ne pas éprouver un sentiment d’impuissance.
Cette adaptabilité forcée les obligent à aller au-delà de leur compétence disciplinaire et à rompre avec une conception individualiste de leur identité professionnelle. Leur métier se joue alors sur la capacité à préserver l’ambition des savoirs tout en créant des situations d’enseignement qui font ordre et sens.
Étudier en lycée professionnel. De l'orientation contrainte à la réhabilitation des élèves, et des savoirs
Authors: Jellab Aziz 
Published: October 2023

Fréquentés pourtant par plus de 700 000 élèves (des secteurs public et privé), les lycées professionnels ont longtemps été stigmatisés. On leur associait l’image d’une institution dominée, peu convoitée, incarnation tangible des inégalités de carrières scolaires, dans la mesure où les élèves qui y «chutent» font l’expérience d’une sélection à la fois scolaire et sociale. Cependant, la réalité de l’expérience des élèves comme des enseignants est autre…
Les entreprises, lieu de socialisation professionnelle. Perception et attitudes des élèves de lycée professionnel
Authors: Oultache Raniha 
Published: October 2023

En France, le lycée professionnel se donne pour objectif la formation des personnels d’exécution (ouvriers et employés). La structuration de cet enseignement repose sur les liens qu’il doit entretenir avec les entreprises. Avec la généralisation des stages, l’entreprise participe à la formation et à la socialisation professionnelle des élèves. Quel est le point de vue des élèves sur les conditions de réalisation de cette alternance ?
Diversité culturelle et combat contre la loi du cumul
Authors: Donnat Olivier 
Published: October 2023

Le thème de la diversité culturelle s’est imposé ces dernières années, dans le prolongement de celui de l’exception qui, dans un premier temps, avait été avancé dans le cadre des négociations internationales sur le commerce pour faire reconnaître le caractère spécifique des biens et services culturels.
Le succès de cette thématique au fondement théorique incertain a été immédiat : tour à tour présentée comme un moyen de défense de la culture «de qualité» contre l’invasion de la sous-culture mondiale, une manière de promouvoir des cultures émergentes (hip hop, arts de la rue…) ou de sauver des cultures minoritaires ou menacées, une arme au service du «patriotisme économique» pour défendre les industries culturelles nationales, la garantie d’une interculturalité harmonieuse…, la diversité culturelle est aujourd’hui mobilisée au service des causes les plus diverses, y compris les plus contradictoires.