bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water insecurity among seasonal agriculture workers: perspectives from Spanish professionals
Authors: Rodríguez-Guerrero Luis Alejandro , Pérez-Urdiales Iratxe , Escrig-Piñol Astrid , Jiménez-Lasserrotte María del Mar , Pastor-Bravo María del Mar , Mateos José Tomás , Briones-Vozmediano Erica 
Published: February 2024

Abstract
Background
Migrant seasonal agricultural workers face conditions of material vulnerability such as inadequate housing difficulties prevent access to running water supplies. The purpose of this study is to explore the perceptions of professionals involved in the care and support of seasonal migrant agricultural workers, as it relates to water access and water consumption and their impact on these workers’ health, in a context of COVID-19 pandemic. Methods: A qualitative exploratory and descriptive study was conducted in 2021 as part of a larger research project, based on 63 personal semi-structured interviews with professionals who provided support to seasonal migrant agricultural workers in three Spanish autonomous regions. COREQ checklist was used for reporting. The interviews were recorded, transcribed, and imported into ATLAS.ti-9 for an inductive thematic analysis. Results: The results have been structured into two main themes: (1) Accessing and obtaining water; and (2) Health problems related to water consumption. Seasonal migrant agricultural workers experience barriers to obtaining safe water for hygiene, cleaning, food preparation and drinking. The implementation of regulations to reduce COVID-19 transmission resulted in improved hygiene levels in the migrants’ quarters, including access to safe drinking water. Conclusion: This study suggests that water insecurity experienced by migrant seasonal agricultural workers in Spain results from their poor living conditions and causes health problems related to a lack of hygiene and the use of unsafe water. Sustainable solutions are needed beyond the pandemic in order to provide migrant workers with adequate living conditions and ensure their water needs are fulfilled.
Can transcranial direct current stimulation combined with interactive computerized cognitive training boost cognition and gait performance in older adults with mild cognitive impairment? a randomized controlled trial
Authors: Lau Chi Ieong , Liu Mu-N , Cheng Fang-Yu , Wang Han-Cheng , Walsh Vincent , Liao Ying-Yi 
Published: February 2024

Abstract
Background
Older adults with Mild Cognitive Impairment (MCI) are often subject to cognitive and gait deficits. Interactive Computerized Cognitive Training (ICCT) may improve cognitive function; however, the effect of such training on gait performance is limited. Transcranial Direct Current Stimulation (tDCS) improves cognition and gait performance. It remains unclear whether combining tDCS with ICCT produces an enhanced synergistic effect on cognition and complex gait performance relative to ICCT alone. This study aimed to compare the effects of tDCS combined with ICCT on cognition and gait performance in older adults with MCI.

Method
Twenty-one older adults with MCI were randomly assigned to groups receiving either anodal tDCS and ICCT ( tDCS + ICCT ) or sham tDCS and ICCT ( sham + ICCT ). Participants played Nintendo Switch cognitive games for 40 min per session, simultaneously receiving either anodal or sham tDCS over the left dorsolateral prefrontal cortex for the first 20 min. Cognitive and gait assessments were performed before and after 15 training sessions.

Results
The global cognition, executive function, and working-memory scores improved in both groups, but there were no significant interaction effects on cognitive outcomes. Additionally, the group × time interactions indicated that tDCS + ICCT significantly enhanced dual-task gait performance in terms of gait speed (p = 0.045), variability (p = 0.016), and dual-task cost (p = 0.039) compared to sham + ICCT.

Conclusion
The combined effect of tDCS and ICCT on cognition was not superior to that of ICCT alone; however, it had a significant impact on dual-task gait performance. Administering tDCS as an adjunct to ICCT may thus provide additional benefits for older adults with MCI.

Trial registration
This trial was registered at http://www.clinicaltrials.in.th/ (TCTR 20,220,328,009).
Staged therapeutic surgery for progressive pulmonary regurgitation and pacemaker induced cardiomyopathy after the tetralogy of fallot repair
Authors: Inno Goki , Itatani Keiichi , Nishiya Kenta , Takahashi Yosuke , Shibata Toshihiko 
Published: February 2024

Abstract
Background
Recently, improvements in the repair of tetralogy of Fallot have increased the need for reoperation in adulthood, and it’s not rare that these reoperation candidates suffer from biventricular failure. However, there are no firm treatment guidelines, and each country, and even each facility, treats each case individually.

Case presentation
We report the successful staged treatment of pulmonary regurgitation and pacemaker-induced cardiomyopathy with biventricular failure in adulthood in a case of complete atrioventricular block after tetralogy of Fallot repair in childhood. We planned a staged therapeutic strategy with preoperative left ventricular volume reduction with medication, following surgical pulmonary valve replacement concomitant epicardial lead implantation on the lateral basal wall, placed just beneath the generator pocket through 3rd intercostal space. in addition to postoperative intervention with a defibrillator to adjust cardiac resynchronization therapy, resulted in improvement of symptoms.

Conclusion
In a patient with biventricular failure after TOF repair, a staged treatment strategy involving medication, PVR, and CRT with a combination of epicardial and intravenous leads could be a useful treatment worth trying before heart transplantation.
Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor
Authors: Högnäsbacka Antonia A. , Poot Alex J. , Plisson Christophe , Bergare Jonas , Bonsall David R. , McCluskey Stuart P. , Wells Lisa A. , Kooijman Esther , Schuit Robert C. , Verlaan Mariska , Beaino Wissam , van Dongen Guus A. M. S. , Vugts Danielle J. , Elmore Charles S. , Passchier Jan , Windhorst Albert D. 
Published: February 2024

Abstract
Background
Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the receptor's function. However, subsequent treatment resistance mutations in the ATP binding site are common. The EGFR allosteric inhibitor, EAI045, is proposed to have an alternative mechanism of action, disrupting receptor signaling independent of the ATP-binding site. The antibody cetuximab is hypothesized to increase the number of accessible allosteric pockets for EAI045, thus increasing the potency of the inhibitor. This work aimed to gain further knowledge on pharmacokinetics, the EGFR mutation-targeting potential, and the influence of cetuximab on the uptake by radiolabeling EAI045 with carbon-11 and tritium.

Results
2-(5-fluoro-2-hydroxyphenyl)-2-((2-iodobenzyl)amino)-N-(thiazol-2-yl)acetamide and 2-(5-fluoro-2-hydroxyphenyl)-N-(5-iodothiazol-2-yl)-2-(1-oxoisoindolin-2-yl)acetamide were synthesized as precursors for the carbon-11 and tritium labeling of EAI045, respectively. [11C]EAI045 was synthesized using [11C]CO in a palladium-catalyzed ring closure in a 10 ± 1% radiochemical yield (decay corrected to end of [11C]CO2 production), > 97% radiochemical purity and 26 ± 1 GBq/µmol molar activity (determined at end of synthesis) in 51 min. [3H]EAI045 was synthesized by a tritium-halogen exchange in a 0.2% radiochemical yield, 98% radiochemical purity, and 763 kBq/nmol molar activity. The ability of [11C]EAI045 to differentiate between L858R/T790M mutated EGFR expressing H1975 xenografts and wild-type EGFR expressing A549 xenografts was evaluated in female nu/nu mice. The uptake was statistically significantly higher in H1975 xenografts compared to A549 xenografts (0.45 ± 0.07%ID/g vs. 0.31 ± 0.10%ID/g, P = 0.0166). The synergy in inhibition between EAI045 and cetuximab was evaluated in vivo and in vitro. While there was some indication that cetuximab influenced the uptake of [3H]EAI045 in vitro, this could not be confirmed in vivo when tumor-bearing mice were administered cetuximab (0.5 mg), 24 h prior to injection of [11C]EAI045.

Conclusions
EAI045 was successfully labeled with tritium and carbon-11, and the in vivo results indicated [11C]EAI045 may be able to distinguish between mutated and non-mutated EGFR in non-small cell lung cancer mouse models. Cetuximab was hypothesized to increase EAI045 uptake; however, no significant effect was observed on the uptake of [11C]EAI045 in vivo or [3H]EAI045 in vitro in H1975 xenografts and cells.
Dual-energy computed tomography in the early evaluation of acute radiation pneumonia
Authors: Wang Zong-Sheng , Wu Jing , Yuan Gang , Liu Yong-Bao , He Xiao-Ping 
Published: February 2024

Abstract
Objective
To investigate the value of dual-energy dual-source computed tomography (DSCT) in evaluating pulmonary perfusion changes before and after radiotherapy for esophageal cancer, and its clinical use in the early diagnosis of acute radiation pneumonia (ARP).

Methods
We selected 45 patients with pathologically confirmed esophageal cancer who received radiotherapy (total irradiation dose of 60 Gy). Dual-energy DSCT scans were performed before and after radiotherapy and the normalized iodine concentrations (NIC) in the lung fields of the areas irradiated with doses of > 20 Gy, 10–20 Gy, 5–10 Gy, and < 5 Gy were measured. We also checked for the occurrence of ARP in the patients, and the differences in NIC values and NIC reduction rates before and after radiotherapy were calculated and statistically analyzed.

Results
A total of 16 of the 45 patients developed ARP. The NIC values in the lung fields of all patients decreased at different degrees after radiotherapy, and the NIC values in the area where ARP developed, decreased significantly. The rate of NIC reduction and incidence rate of ARP increased gradually with the increasing irradiation dose, and the inter-group difference in NIC reduction rate was statistically significant (P < 0.05). Based on the receiver operating characteristic (ROC) curve analysis, the areas under the curves of NIC reduction rate versus ARP occurrence in the V5-10 Gy, V10-20 Gy, and V> 20 Gy groups were 0.780, 0.808, and 0.772, respectively. Sensitivity of diagnosis was 81.3%, 75.0%, and 68.8% and the specificity was 65.5%, 82.8%, and 79.3%, when taking 12.50%, 16.50%, and 26.0% as the diagnostic thresholds, respectively. The difference in NIC values in the lung fields of V<5 Gy before and after radiotherapy was not statistically significant (P > 0.05).

Conclusion
The dual-energy DSCT could effectively evaluate pulmonary perfusion changes after radiotherapy for esophageal cancer, and the NIC reduction rate was useful as a reference index to predict ARP and provide further reference for decisions in clinical practice.
High-fat diet promotes prostate cancer metastasis via RPS27
Authors: Li Dameng , Zhou Xueying , Xu Wenxian , Cai Yongxin , Mu Chenglong , Zhao Xinchun , Tang Tingting , Liang Chen , Yang Tao , Zheng Junnian , Wei Liang , Ma Bo 
Published: February 2024

Abstract
Background
Metastasis is the leading cause of death among prostate cancer (PCa) patients. Obesity is associated with both PCa-specific and all-cause mortality. High-fat diet (HFD) is a risk factor contributing to obesity. However, the association of HFD with PCa metastasis and its underlying mechanisms are unclear.

Methods
Tumor xenografts were conducted by intrasplenic injections. The ability of migration or invasion was detected by transwell assay. The expression levels of RPS27 were detected by QRT-PCR and western blot.

Results
The present study verified the increase in PCa metastasis caused by HFD in mice. Bioinformatics analysis demonstrated increased RPS27 in the experimentally induced PCa in HFD mice, indicating that it is an unfavorable prognostic factor. Intrasplenic injections were used to demonstrate that RPS27 overexpression promotes, while RPS27 knockdown significantly reduces, PCa liver metastasis. Moreover, RPS27 inhibition suppresses the effects of HFD on PCa metastasis. Further mRNA sequencing analysis revealed that RPS27 promotes PCa metastasis by selectively enhancing the expression of various genes.

Conclusion
Our findings indicate that HFD increases the risk of PCa metastasis by elevating RPS27 expression and, subsequently, the expression of genes involved in PRAD progression. Therefore, RPS27 may serve as a novel target for the diagnosis and treatment of metastatic PCa.
Bibliometric analysis of GIS applications in heritage studies based on Web of Science from 1994 to 2023
Authors: Huang Yong 
Published: February 2024

Abstract
Heritage holds significant historical, cultural, or natural value. GIS technology integrates spatial and attribute data of heritage sites, providing a powerful modern tool for better understanding, preservation, and management of heritage resources. To reveal the progress and trends in GIS applications in heritage studies (GIS-Heritage), this study collected and analyzed 1026 relevant research articles published between 1994 and 2023 from the Web of Science database. The analysis was conducted using the VOSviewer software for bibliometric and visualization analysis. The results demonstrated that Italy has made the largest contributions in the field of GIS-Heritage. There exists a close collaboration among research institutions. Journals like the Journal of Cultural Heritage played crucial roles. The most influential authors include Brown, Agapiou, and Nicu. The key research themes identified encompass cultural heritage, GIS, sustainable development, spatial analysis, archaeology, conservation, and photogrammetry. Based on the findings of the bibliometric analysis, this paper puts forward future research recommendations in the field of GIS-Heritage, focusing on data integration, technological innovation, as well as interdisciplinary and international collaboration.
Synthetic interpolated DSA for radiation exposure reduction via gamma variate contrast flow modeling: a retrospective cohort study
Authors: Abumoussa Andrew , Flores Alex , Cornea Christiana M. , Thapa Diwash , Petty Amy , Gelinne Aaron , Elton Scott , Quinsey Carolyn , Sasaki-Adams Deanna , Solander Sten , Ho James , Yap Edward , Lee Yueh Z. 
Published: February 2024

Abstract
Background
Digital subtraction angiography (DSA) yields high cumulative radiation dosages (RD) delivered to patients. We present a temporal interpolation of low frame rate angiograms as a method to reduce cumulative RDs.

Methods
Patients undergoing interventional evaluation and treatment of cerebrovascular vasospasm following subarachnoid hemorrhage were retrospectively identified. DSAs containing pre- and post-intervention runs capturing the full arterial, capillary, and venous phases with at least 16 frames each were selected. Frame rate reduction (FRR) of the original DSAs was performed to 50%, 66%, and 75% of the original frame rate. Missing frames were regenerated by sampling a gamma variate model (GVM) fit to the contrast response curves to the reduced data. A formal reader study was performed to assess the diagnostic accuracy of the “synthetic” studies (sDSA) compared to the original DSA.

Results
Thirty-eight studies met inclusion criteria (average RD 1,361.9 mGy). Seven were excluded for differing views, magnifications, or motion. GVMs fit to 50%, 66%, and 75% FRR studies demonstrated average voxel errors of 2.0 ± 2.5% (mean ± standard deviation), 6.5 ± 1.5%, and 27 ± 2%, respectively for anteroposterior projections, 2.0 ± 2.2%, 15.0 ± 3.1%, and 14.8 ± 13.0% for lateral projections, respectively. Reconstructions took 0.51 s/study. Reader studies demonstrated an average rating of 12.8 (95% CI 12.3−13.3) for 75% FRR, 12.7 (12.2−13.2) for 66% FRR and 12.0 (11.5−12.5) for 50% FRR using Subjective Image Grading Scale. Kendall’s coefficient of concordance resulted in W = 0.506.

Conclusion
FRR by 75% combined with GVM reconstruction does not compromise diagnostic quality for the assessment of cerebral vasculature.

Relevance statement
Using this novel algorithm, it is possible to reduce the frame rate of DSA by as much as 75%, with a proportional reduction in radiation exposure, without degrading imaging quality.

Key points
• DSA delivers some of the highest doses of radiation to patients.
• Frame rate reduction (FRR) was combined with bolus tracking to interpolate intermediate frames.
• This technique provided a 75% FRR with preservation of diagnostic utility as graded by a formal reader study for cerebral angiography performed for the evaluation of cerebral vasospasm.
• This approach can be applied to other types of angiography studies.

Graphical Abstract
Continuing to Talanoa: storytelling dialogues for youth engagement in climate action and justice
Authors: Hautzinger Sarah 
Published: February 2024

AbstractThis article recounts a classroom application of a dialogue, story-telling process used at COPs beginning in 2017. In that year, the Fijian President of the United Nations climate summit, COP23 in Bonn, proposed the entire assembly use his nation’s Talanoa Dialogue process for building ambition for national commitments to the Paris Agreement. When youth, women’s and Indigenous voices were heard in unprecedented ways, many committed to continuing the practice. A florescence of the Asian-Pacific-inspired, conflict-resolution storytelling and dialogue practice ensued, with some continuing for years afterward. This paper recounts eight rounds of varied Talanoa Dialogues employed in higher education contexts. Purposes ranged from internal team-building, to forging community partnerships, to serving as vehicles for youth representation in international contexts like climate COPs. All dialogues nonetheless prioritized listening, recording, and representation through ethnographic, anthropological lenses. These experiences support recommendations to (1) Create chances for youth to listen empathetically to the stories of others in ways attentive to varied national, ethnic and other intersectional (e.g. gendered, class-based) social locations, expanding their awareness and linking their affective and intellectual selves; (2) Make opportunities for youth to voice their own stories and perspectives on climate challenges and work, considering their developmental trajectories in intergenerational contexts, while emphasizing the need to “scale” from individual through global dimensions; (3) Explore the implications of borrowing from exogenous cultural traditions, considering what factors may render this relatively legitimate, as opposed to appropriative. I explore particularities of the cultural origins of Talanoa Dialogues, which mediate hierarchy and egalitarianism, arguing that this function is especially apt for navigating conundrums of youth leadership and so-called “youth-washing.”
Percutaneous balloon-assisted ultrasound-guided direct thrombin embolization of superficial femoral artery pseudoaneurysm: a case series and literature review
Authors: Bruno Antonio , Vendetti Francesco , Papalexis Nicolas , Russo Mattia , Papadopoulos Dimitris , Mosconi Cristina 
Published: February 2024

Abstract
Background
Superficial femoral artery (SFA) pseudoaneurysms, a rare but potentially life-threatening complication, that can arise after vascular interventions or trauma. This case series explores the efficacy and safety of a minimally invasive treatment modality, percutaneous ultrasound-guided thrombin injection (PUGTI) combined with balloon occlusion, in three patients with SFA pseudoaneurysms.

Case presentation
Three patients (age: 71–82 years; 3 female) with SFA pseudoaneurysms underwent PUGTI with balloon occlusion. The procedure involved direct thrombin injection under ultrasound guidance while occluding the parent artery using a balloon catheter. Follow-up was conducted at 1 week and 1 month post-procedure to assess technical success, complications, and recurrence.

Conclusion
PUGTI combined with balloon occlusion appears to be a safe and effective treatment for SFA pseudoaneurysms, particularly for larger pseudoaneurysms. The procedure is associated with a high technical success rate. Balloon occlusion may offer a safer alternative to direct thrombin injection without occlusion, as it potentially minimizes the risk of complications such as distal thromboembolism.
Virtual facilitation best practices and research priorities: a scoping review
Authors: Agulnik Asya , Boykin Derrecka , O’Malley Denalee M. , Price Julia , Yang Mia , McKone Mark , Curran Geoffrey , Ritchie Mona J. 
Published: February 2024

Abstract
Background
Facilitation is an implementation strategy that supports the uptake of evidence-based practices. Recently, use of virtual facilitation (VF), or the application of facilitation using primarily video-based conferencing technologies, has become more common, especially since the COVID-19 pandemic. Thorough assessment of the literature on VF, however, is lacking. This scoping review aimed to identify and describe conceptual definitions of VF, evaluate the consistency of terminology, and recommend “best” practices for its use as an implementation strategy.

Methods
We conducted a scoping review to identify literature on VF following the PRISMA-ScR guidance. A search of PubMed, Embase, Web of Science, and CINAHL databases was conducted in June 2022 for English language articles published from January 2012 through May 2022 and repeated in May 2023 for articles published from January 2012 through April 2023. Identified articles, including studies and conference abstracts describing VF, were uploaded into Covidence and screened independently by two reviewers. Data extraction was done by two reviewers in Microsoft Excel; additionally, studies were evaluated based on the Proctor et al. (2013) reporting guidelines for specifying details of implementation strategies.

Results
The search strategy identified 19 articles. After abstract and full-text screening, eight studies described by 10 articles/abstracts were included in analysis. Best practices summarized across studies included (1) stakeholder engagement, (2) understanding the recipient’s organization, (3) facilitator training, (4) piloting, (5) evaluating facilitation, (6) use of group facilitation to encourage learning, and (7) integrating novel tools for virtual interaction. Three papers reported all or nearly all components of the Proctor et al. reporting guidelines; justification for use of VF was the most frequently omitted.

Conclusions
This scoping review evaluated available literature on use of VF as a primary implementation strategy and identified significant variability on how VF is reported, including inconsistent terminology, lack of details about how and why it was conducted, and limited adherence to published reporting guidelines. These inconsistencies impact generalizability of these methods by preventing replicability and full understanding of this emerging methodology. More work is needed to develop and evaluate best practices for effective VF to promote uptake of evidence-based interventions.

Trial registration
N/A.