bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of habitat suitability and distribution range of the endangered Japanese giant salamander under climate change
Authors: Duret Clément , Bartet Tiphanie , Hambuckers Alain , Kishida Osamu , Okada Sumio , Taguchi Yuki , Takahashi Mizuki K. , Denoël Mathieu 
Published: February 2025

Giant salamanders are the world’s largest amphibians and keystone predators in riverine ecosystems where they face global declines. Identifying environmental variables influencing their distribution is, therefore, an essential step for their conservation. This study aims to assess the current habitat suitability and distribution of the Japanese giant salamander (Andrias japonicus) and to predict changes under future climate scenarios. We used species distribution models (SDMs) over a 282,916 km² area, including 477 high-resolution occurrence data of giant salamanders and seven remote-sensing environmental predictors (climatic, topographic and land use). We projected the prediction maps, identified the most contributing variables and calculated the shifts of suitable areas for three periods (2050, 2070 and 2090) under projected climatic conditions. Climatic variables highly contributed to the distribution of giant salamanders (76% of the total), with preferences for areas with moderate precipitations during cold and wet seasons and mild summer temperatures. A moderately steep surrounding environment was favourable for salamanders, whereas the land-use variables had less influence. Future climate predictions indicate a major decrease of suitable areas. Altogether, our results highlight the habitat preferences of giant salamanders at a broad scale and the negative impact of climate change on future suitable areas. These findings provide important steps for upcoming conservation actions for this threatened species in delineating favourable distribution ranges and priority areas that should be directly affected by climate change. Finally, they emphasise the need for new research at a fine scale on disturbances to the aquatic habitat to enhance the conservation of giant salamanders.
We used a species distribution model (MaxEnt), high-resolution occurrence data and remote sensing data (climatic, topographic and land use) to identify suitable habitats for the Japanese giant salamander in Japan.
The most suitable environments for the Japanese giant salamander are located both within and beyond its current distribution range, with the ‘Japanese Alps’ forming an impassable natural barrier.
Among the variables studied, precipitation of the warmest quarter, precipitation of the coldest quarter, mean temperature of the warmest quarter and mean temperature of the wettest quarter were the most important environmental predictors of the species’ distribution.
Climate change is expected to severely reduce the potential suitable geographical areas for the Japanese giant salamander in the future.
The present work calls for new surveys based on the projected maps to improve the mapping of salamander distribution and to focus on ecological features and threats at the aquatic habitat level to understand the risks to their populations.
Polyphenol extraction from industrial water by-products: a case study of the ULTIMATE project in the fruit processing industry
Authors: Christophoridis Christophoros , Touloupi Myrto , Bizani Erasmia A. , Iossifidis Dimitri 
Published: February 2025

ABSTRACT
This study investigates the sustainable management and utilization of water resources in the fruit processing industry, focusing on a case study from the EU-funded ULTIMATE project. Conducted in a juice factory in Nafplio, Greece, the primary objective is to explore the recovery of polyphenols from water by-product streams generated during orange juice production. The research aims to evaluate the effectiveness of a mobile wastewater treatment unit in selectively adsorbing polyphenols onto a polymeric resin. The following three extraction methods are compared: conventional solvent extraction, subcritical water extraction (SWE), and supercritical CO2 extraction (SFE). To determine the most efficient extraction method, the polyphenol profiles of the extracts were analyzed using UHPLC-Q-Orbitrap-MS/MS, identifying flavonoids, terpenes, coumarins, and anthocyanins. SFE not only was the most efficient method but provided the most diverse and abundant profile. The research highlights the potential of converting industrial by-products that would otherwise be treated as wastewater, into valuable resources that generate revenue, promote circular economy practices, and enhance sustainability in the fruit and vegetable processing sector. The economic viability of polyphenol extraction is also discussed, emphasizing its significance and impact on various industries. The findings support integrating advanced extraction technologies to maximize resource recovery and minimize environmental impact.
Digital Health Program to Support Family Caregivers of Children Undergoing Growth Hormone Therapy: Qualitative Feasibility Study
Authors: Jiménez-Díaz Alba , Pierantonelli Maitena , Morte Coscolín Patricia , Salinas-Uhalte Amaia , Quer-Palomas Silvia , Rivera-Romero Octavio , Herrero Rocío , Fernández-Luque Luis , Baños Rosa , Berrios Ricardo C , de Arriba Antonio 
Published: February 2025

Background
Caregivers of children with growth hormone deficiency often face emotional challenges (eg, stress) associated with their children’s health conditions. This psychological burden might affect children’s adherence to treatment and hinder their health-related quality of life (HrQoL). This assumption is leading to seriously considering multidimensional clinical approaches to pediatric health conditions where the emotional well-being of caregivers should be accounted for to optimize children’s health outcomes. Novel mobile health (mHealth) solutions based on emotional and behavioral change techniques can play a promising role because they are increasingly used within different health areas to support adaptive psychological functioning. However, whether and how mHealth solutions of this type of emotional well-being support caregivers of children with growth-related problems is an issue that needs to be clarified.

Objective
This study aimed to gather qualitative information to better understand individualized experiences of caregiving of children undergoing growth hormone therapy (GHt) and perceived barriers or facilitators for the adoption of an mHealth solution called Adhera Caring Digital Program (ACDP).

Methods
A total of 10 family caregivers were recruited at Miguel Servet Children’s Hospital, and they engaged with the ACDP for 1 month. The ACDP is a mobile-based digital intervention focused on promoting the overall well-being of family caregivers which provides access to personalized education, motivational mobile-based messages, and mental well-being exercises such as mindfulness or respiratory exercises. Subsequently, an individual semistructured interview was performed to gather qualitative user experience information.

Results
The digital intervention was well-received. The ACDP was found to be useful, easy to use, and understandable, addressing all the difficulties expressed by caregivers. It was also noted to be particularly helpful at the beginning of the treatment and, for some families, became a natural tool that strengthened the parent-child relationship.

Conclusions
The ACDP is a promising and well-accepted tool that enhances the experience of patients and caregivers. It improves the management of growth hormone deficiency and promotes the overall well-being of family caregivers.

Trial Registration
ClinicalTrials NCT04812665; https://clinicaltrials.gov/study/NCT04812665

International Registered Report Identifier (IRRID)
RR2-10.1186/s12911-022-01935-1
Enhancing Older Adults’ Lives Through Positive Aging Perception, Quality-of-Life Enhancement, and Social Support to Drive Acceptance and Readiness Toward Indoor Assistive Technology: Cross-Sectional Study
Authors: Wong Ka Po , Teh Pei-Lee , Lim Weng Marc , Lee Shaun Wen Huey 
Published: February 2025

Background
The growing aging population faces increasing mobility limitations, highlighting the need for assistive technologies as potential solutions. These technologies support the independence and well-being of older adults and individuals with mobility challenges. Indoor mobility is essential for daily activities and significantly impacts their lives. Limited indoor mobility can reduce quality of life and heighten the risk of falls.

Objective
This study explores how positive aging perceptions, quality-of-life enhancements, and social support influence the acceptance and readiness of indoor assistive technologies among older adults.

Methods
A cross-sectional study was conducted at a gerontechnology laboratory, requiring participants to visit the facility in person. Each 60-minute session included demonstrations of various indoor assistive technologies and the completion of a questionnaire. The assistive technologies showcased encompassed a wide range of devices. Participants’ positive aging perceptions, quality-of-life enhancements, social support, technology acceptance, and readiness were measured using validated scales. Data were analyzed with AMOS (version 28; IBM Corp) and SPSS (version 28; IBM Corp), using structural equation modeling and multivariate analysis of covariance to assess the effects of predictors while controlling for demographic factors.

Results
A total of 104 older adults aged 60 years and older participated, with a mean age of 67.92 (SD 5.68) years. Structural equation modeling indicated that positive aging perception has a significant influence on older adults’ control beliefs (P=.095), comfort (P=.047), and confidence (P<.001) in gerontechnology. Multivariate analysis revealed significant combined effects of quality-of-life enhancement (P=.01) and social support (P=.03) on technology acceptance and readiness, wherein quality-of-life enhancement (P=.001) and social support (P=.008) negatively impacted security perception. Among demographic variables, educational level significantly impacted gerontechnology confidence (P=.004) while ethnicity influenced optimism (P=.003).

Conclusions
This study sheds light on key factors affecting older adults’ acceptance and readiness to adopt indoor assistive technologies. Findings highlight the importance of fostering positive aging perceptions through these technologies. Addressing issues related to control beliefs, comfort, and confidence in gerontechnology is essential to enhance technology acceptance and readiness among older adults. Future research should investigate the underlying mechanisms and create targeted interventions to support successful technology adoption in this population.
The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial
Authors: Biello Katie B , Mayer Kenneth H , Scott Hyman , Valente Pablo K , Hill-Rorie Jonathan , Buchbinder Susan , Ackah-Toffey Lucinda , Sullivan Patrick S , Hightow-Weidman Lisa , Liu Albert Y 
Published: February 2025

Background
Young sexual minority men have among the highest rates of HIV in the United States; yet, the use of evidence-based prevention strategies, including routine HIV testing and pre-exposure prophylaxis (PrEP), remains low. Mobile apps have enormous potential to increase HIV testing and PrEP use among young sexual minority men.

Objective
This study aims to assess the efficacy of 2 theory- and community-informed mobile apps—LYNX (APT Mobility) and MyChoices (Keymind)—to improve HIV testing and PrEP initiation among young sexual minority men.

Methods
Between October 2019 and May 2022, we implemented a 3-arm, parallel randomized controlled trial in 9 US cities to test the efficacy of the LYNX and MyChoices apps against standard of care (SOC) among young sexual minority men (aged 15-29 years) reporting anal sex with cisgender male or transgender female in the last 12 months. Randomization was 1:1:1 and was stratified by site and participant age; there was no masking. The co-primary outcomes were self-reported HIV testing and PrEP initiation over 6 months of follow-up.

Results
A total of 381 young sexual minority men were randomized. The mean age was 22 (SD 3.2) years. Nearly one-fifth were Black, non-Hispanic (n=67, 18%), Hispanic or Latino men (n=67, 18%), and 60% identified as gay (n=228). In total, 200 (53%) participants resided in the Southern United States. At baseline, participants self-reported the following: 29% (n=110) had never had an HIV test and 85% (n=324) had never used PrEP. Sociodemographic and behavioral characteristics did not differ by study arm. Compared to SOC (n=72, 59%), participants randomized to MyChoices (n=87, 74%; P=.01) were more likely to have received at least 1 HIV test over 6 months of follow-up; those randomized to LYNX also had a higher proportion of testing (n=80, 70%) but it did not reach the a priori threshold for statistical significance (P=.08). Participants in both MyChoices (n=23, 21%) and LYNX (n=21, 20%) arms had higher rates of starting PrEP compared to SOC (n=19, 16%), yet these differences were not statistically significant (P=.52).

Conclusions
In addition to facilitating earlier treatment among those who become aware of their HIV status, given the ubiquity of mobile apps and modest resources required to scale this intervention, a 25% relative increase in HIV testing among young sexual minority men, as seen in this study, could meaningfully reduce HIV incidence in the United States.

Trial Registration
ClinicalTrials.gov NCT03965221; https://clinicaltrials.gov/study/NCT03965221
Nurses’ Perspectives and Experiences of Using a Bed-Exit Information System in an Acute Hospital Setting: Mixed Methods Study
Authors: Walzer Stefan , Schön Isabel , Pfeil Johanna , Klemm Sam , Ziegler Sven , Schmoor Claudia , Kunze Christophe 
Published: February 2025

Background
Technology that detects early when a patient at risk of falling leaves the bed can support nurses in acute care hospitals.

Objective
To develop a better understanding of nurses’ perspectives and experiences with a bed-exit information system (BES) in an acute care hospital setting.

Methods
BES was implemented on 3 wards of a university medical center. Nurses completed 2 online surveys at each time point (P0 and P1) and participated in focus groups before (P0) and after (P1) implementation. Additional patient data were collected. Descriptive statistics summarized the survey results, while content analysis was applied to focus group data. Patient rates and adverse events in both phases were compared using negative binomial models. Reporting of this study adhered to the GRAMMS checklist.

Results
A total of 30 questionnaires were completed at P0 (30/72, 42%) and 24 at P1 (24/71, 33%). Of the participants, 15 completed both questionnaires (complete cases). At P1, 64% (9/14) of participants agreed that their perceived workload and strain in caring for patients with cognitive impairment was reduced by the use of the BES. The adverse event rate per patient per day was reduced by a factor of 0.61 (95% CI 0.393-0.955; P=.03). In addition, 11 nurses participated in 4 focus groups before and after the intervention. Participants found it challenging to operationalize the use of the BES due to the heterogeneity of care settings, but certain behaviors of patients with cognitive impairment were recognized as indicating a need for intervention. Negative experiences included information overload and alarm fatigue, leading to occasional removal of the system.

Conclusions
While BES provides some support in managing patients with cognitive impairment, its impact remains limited to specific scenarios and does not significantly reduce nurses’ workload or strain. Our findings highlight the need to manage expectations of BES performance to ensure alignment between expected and actual benefits. To improve BES effectiveness and long-term implementation, future research should consider both objective measures of patient care and subjective factors such as nurse experience, structural conditions, and technical specifications. Improving information mechanisms within call systems could help reduce alarm fatigue and increase perceived usefulness. Overall, successful integration of BES in acute care settings will require close collaboration with nursing staff to drive meaningful healthcare innovation and ensure that the technology meets the needs of both patients and nurses.

Trial Registration
German Register for Clinical Studies DRKS00021720; https://drks.de/search/de/trial/DRKS00021720
HUBUNGAN KARAKTERISTIK PASIEN DENGAN KEPUASAN PELAYANAN DI UPTD PUSKESMAS PANTOLOAN, KOTA PALU
Authors: Suwendro Novi Inriyanny 
Published: February 2025

Latar Belakang: Pelayanan kesehatan di puskesmas memainkan peran krusial dalam menyediakan akses yang merata dan terjangkau ke layanan kesehatan masyarakat. Puskesmas Pantoloan mengalami penurunan Indeks Kepuasan Masyarakat (IKM) dari tahun 2021 ke 2022. Dalam mengoptimalkan kualitas pelayanan di puskesmas, pemahaman yang mendalam tentang faktor- faktor yang memengaruhi kepuasan pasien menjadi sangat penting. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara karakteristik pasien (umur, jenis kelamin, pendidikan, pekerjaan, dan pendapatan) dengan kepuasan pelayanan di Puskesmas Pantoloan, Palu. Metode: Penelitian menggunakan desain cross- sectional dengan sampel sebanyak 100 responden. Data dianalisis menggunakan uji Chi-Square. Hasil dan Kesimpulan: Hasil penelitian menunjukkan bahwa terdapat hubungan signifikan antara umur, jenis kelamin, pendidikan, dan pekerjaan dengan kepuasan pelayanan, namun tidak ada hubungan signifikan dengan pendapatan. Penelitian ini memberikan wawasan bagi peningkatan kualitas pelayanan puskesmas.

Kata kunci: karakteristik pasien, kepuasan pasien, puskesmas, pelayanan kesehatan

Background: Health services at community health centers play a crucial role in providing equitable and affordable access to public health services. The Pantoloan Community Health Center experienced a decrease in the Community Satisfaction Index (IKM) from 2021 to 2022. In optimizing the quality of service at the community health center, a deep understanding of the factors that influence patient satisfaction is very important. Objective: This study aims to analyze the relationship between patient characteristics (age, gender, education, employment and income) and service satisfaction at the Pantoloan Community Health Center, Palu. Method: The research used a cross-sectional design with a sample of 100 respondents. Data were analyzed using the Chi-Square test. Results and Conclusions: The results of the study show that there is a significant relationship between age, gender, education and employment with service satisfaction, but there is no significant relationship with income. This research provides insight into improving the quality of community health center services.

Key words: patient characteristics, patient satisfaction, health center, health services
Pelatihan Upaya Berhenti Merokok
Authors: Trisnowati Heni , Suryana Aufatcha Ayutya 
Published: February 2025

Jumlah perokok remaja di Indonesia terus mengalami peningkatan. Kawasan tanpa rokok di tempat belajar mengajar merupakan salah satu upaya untuk melindungi warga kampus dari paparan asap rokok dan untuk mewujudkan lingkungan kampus yang sehat dan produktif. Hasil need assesment salah satu kampus di Yogyakarta, masih ditemukan puntung rokok dan bau asap rokok di area kampus. Sebagian besar perokok mempunyai keinginan untuk berhenti merokok namun merasa kesulitan untuk berhenti merokok. Tujuan penelitian ini adalah untuk meningkatkan pengetahuan dan mengidentifikasi motivasi calon konselor Upaya Berhenti Merokok. Intervensi dilakukan melalui pelatihan sehari dengan metode, ceramah, role play dan diskusi tanya jawab. Media yang digunakan adalah lembar balik untuk konseling berhenti merokok. Sampel ditentukan secara purposive sampling yang terdiri dari mahasiswa dan dosen sebanyak 30 orang. Dilakukan pretes dan postes sebelum dan sesudah pelatihan. Hasil evaluasi proses menunjukkan adanya peningkatan skor rata-rata untuk pengetahuan yang mencakup dampak rokok terhadap kesehatan, tata laksana upaya berhenti merokok dan manajemen upaya berhenti merokok di kampus. Hasil uji statistik dengan Pair T test diperoleh nilai significancy 0,000 (p<0,05). Motivasi peserta pelatihan terbagi menjadi tiga ketegori yaitu meningkatkan kapasitas diri, melakukan aksi promosi kesehatan, dan bentuk kepedulian terhadap kesehatan. Pelatihan upaya berhenti merokok terbukti dapat meningkatkan pengetahuan peserta pelatihan. Motivasi peserta pelatihan menjadi hal penting yang menentukan keberlanjutan program. Selain itu diperlukan komitmen yang kuat dari pemegang program dan mitra, serta dukungan dana sangat diperlukan untuk kelancaran pelaksanaan program.
Distal paravertebral block anesthesia with a mixture of lidocaine and xylazine has a longer duration than a lidocaine block coupled with intramuscular xylazine in steers
Authors: Varner Kelley M. , Keefer Maya , Mooring Margaret , Klein Sarah , Love Kim 
Published: February 2025

Abstract

OBJECTIVE
To determine whether the site of administration of xylazine alters its impact on lidocaine’s duration of action when administered as a distal paravertebral block (DPV) in steers.

METHODS
6 healthy steers were used. Unilateral DPVs were performed at L1, L2, and L4. Each steer received 2 treatments in a blinded random crossover study. The local xylazine treatment group received 6 mg of lidocaine/kg mixed with 0.02 mg of xylazine/kg as a DPV, followed by an injection of 0.9% NaCl in the cervical musculature. The systemic xylazine treatment group received 6 mg of lidocaine/kg as a DPV and 0.02 mg of xylazine/kg in the cervical musculature. Sensation was assessed by response to needle pricks along the paralumbar fossa with a 22-gauge hypodermic needle. The time of onset, duration of action, sedation score, and heart rate were compared between treatments. Data are reported as mean ± SD. This study was completed over a 2-week period in May 2023.

RESULTS
The duration of anesthesia was significantly prolonged after DPV in steers treated with local xylazine (186.7 ± 58.7 minutes) compared to systemic xylazine (95 ± 36.3 minutes). Both treatments were associated with mild decreases in heart rate and sedation but were not significantly different between groups.

CONCLUSIONS
The addition of xylazine to lidocaine when administered as a DPV provides a longer duration of anesthesia than when xylazine is administered at a distant site to local anesthetic solution deposition.

CLINICAL RELEVANCE
The combination of lidocaine and xylazine when administered as a DPV prolongs the duration of action of lidocaine and is a practical, inexpensive technique.