bluuebunny/crossref_metadata_2025_split huggingface dataset:
International school educators and their children
Authors: Zilber Ettie 
Published: March 2005

English What is the impact of the international school experience on the children of educators who live and study in close proximity with their parents and parents' colleagues? In this study, educators, who are teachers, counselors, specialists and administrators, describe their impressions of the benefits and challenges of this unique expatriate family experience. Many of the challenges are due to the multiple, and sometimes blurred, roles of both the educator-parents and their children. Raising children overseas within the international school context, however, was evaluated by most participants as a positive and rewarding experience for all members of the family. French Quel impact ont les établissements scolaires internationaux sur les enfants des agents d'éducation qui vivent et étudient à proximité de leurs parents et des collÉgues de ces derniers? Dans cette étude, des agents d'éducation, c'est à dire des enseignants, des conseillers pédagogiques et des membres de la direction, partagent leurs impressions sur les avantages et les inconvénients de cette expérience unique parmi les familles expatriées. Plusieurs inconvénients sont dus aux rôles multiples et parfois flous des parents agents d'éducation et de leurs enfants. Cependant, élever des enfants à l'étranger dans le cadre d'un établissement scolaire international a été décrit par la plupart des participants comme étant une expérience positive et enrichissante pour tous les membres de la famille. Spanish 'Cómo afecta la experiencia de la educación internacional a los hijos de educadores que viven y estudian en estrecha proximidad con sus padres y los colegas de sus padres? En este artículo, varios educadores (profesores, pedagogos, especialistas y directores de colegios) describen'sus impresiones sobre los beneficios y las dificultades de esta experiencia familiar única de vivir y recibir educación en el extranjero. Muchas de las dificultades se deben a los múltiples (y a veces difusos) roles de los educadores-padres y de sus hijos. La'mayoría de los participantes consideraron que educar a hijos en el'extranjero en el contexto de un colegio internacional es una experiencia positiva y gratificante para toda la familia.
Culture shock and the international student ‘offshore’
Authors: Pyvis David , Chapman Anne 
Published: March 2005

English Within the context of higher education, it is the international student who travels to another country to study who is typically identified as the subject at risk of culture shock. This paper attempts to go further by suggesting that international students studying in their home country with an overseas institution may also experience culture shock as an effect of this engagement. To support this contention, the paper reports findings of an interpretive case study of a group of masters' degree students in Singapore taught by an Australian university in partnership with a local provider. French Dans l'enseignement supérieur, les étudiants internationaux s'installant dans un pays étranger dans le cadre de leurs études sont en principe identifiés comme des sujets à risque de choc culturel. Cet'article tente d'approfondir cette réflexion en suggérant que les étudiants internationaux scolarisés dans un établissement étranger implanté dans leur pays d'origine connaissent également un choc culturel. Pour justifier cet argument, l'article rend compte des résultats d'une étude de cas interprétative portant sur un groupe d'étudiants de maîtrise à Singapour étudiant dans une université australienne en partenariat avec un prestataire local. Spanish En el contexto de la educación superior, son los estudiantes internacionales que se trasladan a estudiar al extranjero a quienes generalmente se identifica como individuos con riego de choque cultural. Este artículo va más allá y sugiere que los estudiantes internacionales que cursan estudios en sus países de origen en una institución extranjera también pueden experimentar un choque cultural. Para justificar este argumento, el artículo presenta los resultados de un estudio de caso de carácter interpretativo sobre un grupo de estudiantes de un máster impartido en Singapur por una universidad australiana en asociación con una institución local.
Perspectives on international schools and the nature and extent of local community contact
Authors: Bunnell Tristan 
Published: March 2005

English The concept of public relations is a wide-ranging one and local community contact is usually a key area of activity. This activity with regard to international schools has generally drawn criticism from writers. It is a complex and ever-changing relationship, yet is arguably central to the founding ethos of many schools. This paper reports on the surveying of 34 schools in 22 different countries, which revealed that they undertook little formal contact with the local community. Several possible political and moral reasons for this are discussed and outlined alongside a number of possible management and organizational factors. French Les relations publiques sont un concept largement répandu et les relations avec la communauté locale sont généralement un secteur d'activité clé. Dans ce domaine d'activité, les établissements scolaires internationaux ont fait l'objet de critiques de la part de certains auteurs. Ce sont des relations complexes, en constante évolution et néanmoins primordiales à l'ethos fondateur de nombreux établissements. Cet article fait état d'une étude menée dans 34 établissements dans 22 pays différents et qui révèle que ces derniers établi peu de contacts formels avec leur communauté locale. Plusieurs raisons politiques et morales pouvant expliquer ce fait sont examinées et exposées ici, parallèlement à de possibles facteurs organisationnels et de gestion. Spanish El concepto de relaciones públicas es muy amplio y el contacto con la comunidad local es generalmente un área de actividad clave. Algunos autores han criticado la relación existente entre los colegios internacionales y la comunidad local. Üsta es una relación compleja, en constante evolución, pero podría decirse que forma una parte esencial de los valores fundamentales de muchos colegios. Este artículo presenta los resultados de un estudio realizado en 34 colegios de 22 países distintos y revela que éstos últimos mantienen escaso contacto formal con sus comunidades locales. Se intenta explicar este fenómeno con posibles razones morales y políticas, así como una serie de posibles factores organizativos y de gestión.
Internationalization strategies in Japan
Authors: Tsuneyoshi Ryoko 
Published: March 2005

English In the past few decades, new governmental efforts to internationalize Japanese higher education have been in progress. One move has been to provide assistance to study abroad programs using English as the language of instruction. Though seen as an effective internationalization strategy, the consequences are by no means culturally neutral. This article focuses on the critical case of the University of Tokyo, the oldest national university in Japan. Analyzing the first four years of the implementation of English-medium lectures, the article analyzes the consequences, especially the cultural dilemmas that arise alongside the adoption of a foreign language - English - as the medium of instruction. French Au cours des dernières décennies, de nouveaux efforts gouvernementaux ont été développés afin d'internationaliser l'enseignement supérieur au Japon. Ces efforts ont notamment porté sur l'aide apportée pour étudier à l'étranger des programmes d'études utilisant l'anglais comme langue d'enseignement. Bien que ces efforts sont perµus comme une véritable stratégie d'internationalisation, leurs conséquences ne sont pas 'culturellement neutres'. Cet article se concentre sur le cas de l'Université de Tokyo, qui est la plus ancienne université du Japon. Se basant sur l'étude des quatre premières années de la mise en place des cours dispensés en anglais, cet article analyse les conséquences et plus particulièrement les dilemmes culturels que suscite l'adoption d'une langue étrangère, à savoir l'anglais, comme langue d'apprentissage. Spanish En las últimas décadas, hemos presenciado nuevos esfuerzos por parte del gobierno para lograr la internacionalización de la educación superior japonesa. Una de las iniciativas ha consistido en proporcionar apoyo a los programas de estudio en el extranjero utilizando el inglés como lengua de instrucción. Aunque se la considera una estrategia de internacionalización eficaz, resulta evidente que tiene ciertas consecuencias culturales. Este artículo se centra en el caso de la Universidad de Tokio, la universidad nacional más antigua de Japón. A través del análisis de los primeros cuatro años en que las clases se han dictado en idioma inglés, el artículo estudia las consecuencias que ello ha tenido, y especialmente los dilemas culturales vinculados a la adopción de un idioma extranjero como lengua de instrucción.
Looking through old lenses to understand the emerging new world order
Authors: Pillay Hitendra , Elliott Bob 
Published: March 2005

English There is increasing pressure on small island states to reconceptualize education policies, education management practices and curriculum to address the emerging issues caused by global economic, social and cultural changes. It has generated increasing demands on limited available resources which is further confounded by the often contradictory yet legitimate advice provided by international and local experts. This paper reflects on the changing expectations to provide a critical analysis of the challenges facing education planners in small developing countries. It challenges them to move beyond the stereotypical ways of thinking about education development while acknowledging the role played by previous educational development models. French Les petits états insulaires font l'objet de pressions croissantes pour reconceptualiser leur politique en matière d'éducation, leurs méthodes de gestion de la formation et leurs programmes et ce afin de pouvoir faire face aux problèmes croissants causés par les changements économiques, sociaux et culturels mondiaux. Cette situation a généré une demande croissante de ressources disponibles limitées, accentuée par les conseils, certes souvent contradictoires mais néanmoins légitimes, fournis par des experts internationaux et locaux. Cet article se penche sur ces perspectives d'évolution pour fournir une analyse critique des problèmes rencontrés par les personnes chargées de la planification de l'éducation dans les petits pays en voie de développement. Il les encourage à dépasser les réflexions stéréotypées sur le perfectionnement en matière d'éducation tout en reconnaissant l'importance des précédents modèles de perfectionnement de l'enseignement. Spanish Existe una presión cada vez mayor para que los estados insulares pequeños reconceptualicen sus políticas, sus prácticas de gestión y sus'currículos educativos para poder afrontar las cuestiones derivadas de los cambios económicos, sociales y culturales que se están produciendo en todo el mundo. Este fenómeno implica un aumento de las exigencias sobre los recursos disponibles, a lo cual se agrega una cierta confusión causada por los consejos de expertos locales e internacionales que, no obstante legítimos, a menudo se contradicen. Este trabajo aporta una reflexión sobre las expectativas planteadas, con el fin de ofrecer un análisis crítico de los desafíos a los que se enfrentan los encargados de la planificación educativa en pequeños estados insulares. Se propone hacerles pensar en el desarrollo de la educación más allá de los estereotipos imperantes, y reconocer la influencia de los modelos anteriores en las políticas actuales.
Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
Authors: del Conde Ian , Shrimpton Corie N. , Thiagarajan Perumal , López José A. 
Published: March 2005

AbstractTissue factor (TF) circulates in plasma, largely on monocyte/macrophage-derived microvesicles that can bind activated platelets through a mechanism involving P-selectin glycoprotein ligand-1 (PSGL-1) on the microvesicles and P-selectin on the platelets. We found these microvesicles to be selectively enriched in both TF and PSGL-1, and deficient in CD45, suggesting that they arise from distinct membrane microdomains. We investigated the possibility that microvesicles arise from cholesterol-rich lipid rafts and found that both TF and PSGL-1, but not CD45, localize to lipid rafts in blood monocytes and in the monocytic cell line THP-1. Consistent with a raft origin of TF-bearing microvesicles, their shedding was significantly reduced with depletion of membrane cholesterol. We also evaluated the interaction between TF-bearing microvesicles and platelets. Microvesicles bound only activated platelets, and required PSGL-1 to do so. The microvesicles not only bound the activated platelets, they fused with them, transferring both proteins and lipid to the platelet membrane. Fusion was blocked by either annexin V or an antibody to PSGL-1 and had an important functional consequence: increasing the proteolytic activity of the TF-VIIa complex. These findings suggest a mechanism by which all of the membrane-bound reactions of the coagulation system can be localized to the surface of activated platelets.
Myelodysplasia and acute myeloid leukemia following therapy for indolent lymphoma with fludarabine, mitoxantrone, and dexamethasone (FND) plus rituximab and interferon alpha
Authors: McLaughlin Peter , Estey Elihu , Glassman Armand , Romaguera Jorge , Samaniego Felipe , Ayala Ana , Hayes Kimberly , Maddox Anne Marie , Preti H. Alejandro , Hagemeister Fredrick B. 
Published: March 2005

Abstract
Treatment-related myelodysplasia (t-MDS) occurs less frequently with the nucleoside analogs than with DNA-damaging agents such as alkylators or topoisomerase II inhibitors. In a chemoimmunotherapy trial conducted between 1997 and 2003 in patients with stage IV indolent lymphoma, 202 patients were treated and 8 have developed MDS between 1 and 5 years after therapy, including 4 who received only fludarabine, mitoxantrone, and dexamethasone (FND) for 6 to 8 courses, with or without rituximab, followed by interferon alpha (IFN-α). Complex cytogenetic abnormalities were present in all patients. Abnormalities of chromosome 7 were present in 6 of the 8 patients, 3 of whom received only FND ± rituximab and IFN-α. The abnormalities of chromosome 7 were monosomy 7 in 4 patients (1 of which had add 7p in the remaining chromosome); 1 del 7q; and 1 der 7. MDS with features classically associated with DNA-damaging agents can occur following therapy with FND, with or without rituximab, and IFN-α. (Blood. 2005;105:4573-4575)
Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential
Authors: Watanabe Norihiko , Hanabuchi Shino , Marloie-Provost Marie-Annick , Antonenko Svetlana , Liu Yong-Jun , Soumelis Vassili 
Published: March 2005

AbstractInterleukin-4 (IL-4), a major T-helper type 2 (Th2) cytokine, primes dendritic cells (DCs) for IL-12 production, suggesting a negative feedback loop to prevent dysregulated Th2 inflammation, such as allergy. We previously showed that human thymic stromal lymphopoietin (TSLP), highly expressed by keratinocytes of atopic dermatitis, activates CD11c+ DCs to induce the differentiation of naive CD4+ and CD8+ T cells into proallergic effectors. Here we show that TSLP primes DCs to produce large amounts of IL-12 after CD40 ligand stimulation, similar to IL-4 priming of DCs. In contrast to IL-4 priming, DCs activated with TSLP and CD40 ligand induce the differentiation of naive CD4+ T cells into effectors producing both Th1 and Th2 cytokines, a unique profile that is reminiscent of the late phase of allergy. Thus, TSLP is a major regulatory cytokine for IL-12 production by DCs, and TSLP-activated DCs could promote the persistence of Th2 inflammation even in the presence of IL-12-inducing signals. (Blood. 2005;105:4749-4751)
Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma
Authors: Mikaelsson Eva , Danesh-Manesh Amir Hossein , Lüppert Alfred , Jeddi-Tehrani Mahmood , Rezvany Mohammad-Reza , Sharifian Ramazan Ali , Safaie Reza , Roohi Azam , Österborg Anders , Shokri Fazel , Mellstedt Håkan , Rabbani Hodjattallah 
Published: March 2005

AbstractFibromodulin is an extracellular matrix protein normally produced by collagen-rich tissues; the fibromodulin gene has been found to be the most overexpressed gene in B-cell chronic lymphocytic leukemia. In this study, fibromodulin was expressed at the gene level (reverse transcription-polymerase chain reaction [RT-PCR]) in all patients with B-CLL (n = 75) and in most (5 of 7) patients with mantle cell lymphoma (MCL). No mutations in the fibromodulin gene were detected. Fibromodulin was also detected at the protein level in the cytoplasm of the B-CLL cells and in the supernatant after in vitro cultivation, but not at the cell surface. Fibromodulin was not found in patients with T-cell chronic lymphocytic leukemia (T-CLL), B-cell prolymphocytic leukemia (B-PLL), T-cell prolymphocytic leukemia (T-PLL), hairy cell leukemia, follicular lymphoma, lymphoplasmacytic lymphoma, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), or chronic myelogenous leukemia (CML) or in 36 hematologic cell lines. Normal blood mononuclear cells (T and B lymphocytes, monocytes), tonsil B cells, and granulocytes did not express fibromodulin. Activation (phorbol 12-myristate 13-acetate [PMA]/ionomycin) of normal T and B lymphocytes induced weak fibromodulin gene expression, but not to the extent seen in freshly isolated B-CLL cells. The reason for the exclusive ectopic expression of fibromodulin in B-CLL and MCL is unknown. However, its unique protein expression makes it likely that fibromodulin is involved in the pathobiology of B-CLL and MCL. (Blood. 2005;105:4828-4835)
Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation
Authors: Martin Falk , Linden Tobias , Katschinski Dörthe M. , Oehme Felix , Flamme Ingo , Mukhopadhyay Chinmay K. , Eckhardt Katrin , Tröger Juliane , Barth Sandra , Camenisch Gieri , Wenger Roland H. 
Published: March 2005

AbstractCellular oxygen partial pressure is sensed by a family of prolyl-4-hydroxylase domain (PHD) enzymes that modify hypoxia-inducible factor (HIF)α subunits. Upon hydroxylation under normoxic conditions, HIFα is bound by the von Hippel-Lindau tumor suppressor protein and targeted for proteasomal destruction. Since PHD activity is dependent on oxygen and ferrous iron, HIF-1 mediates not only oxygen- but also iron-regulated transcriptional gene expression. Here we show that copper (CuCl2) stabilizes nuclear HIF-1α under normoxic conditions, resulting in hypoxia-response element (HRE)-dependent reporter gene expression. In in vitro hydroxylation assays CuCl2 inhibited prolyl-4-hydroxylation independently of the iron concentration. Ceruloplasmin, the main copper transport protein in the plasma and a known HIF-1 target in vitro, was also induced in vivo in the liver of hypoxic mice. Both hypoxia and CuCl2 increased ceruloplasmin (as well as vascular endothelial growth factor [VEGF] and glucose transporter 1 [Glut-1]) mRNA levels in hepatoma cells, which was due to transcriptional induction of the ceruloplasmin gene (CP) promoter. In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively. (Blood. 2005;105:4613-4619)
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors
Authors: Jolly Puneet S. , Bektas Meryem , Watterson Kenneth R. , Sankala Heidi , Payne Shawn G. , Milstien Sheldon , Spiegel Sarah 
Published: March 2005

AbstractMast cells play a central role in inflammatory and immediate-type allergic reactions by secreting a variety of biologically active substances, including sphingosine-1 phosphate (S1P). Sphingosine kinase 1 (SphK1) and formation of S1P, which leads to transactivation of S1P receptors and their downstream signaling pathways, regulates mast-cell functions initiated by cross-linking of the high-affinity immunoglobulin E (IgE) receptor FcϵRI. Surprisingly, overexpression of SphK1 in rat basophilic leukemia (RBL)-2H3 mast cells impaired degranulation as well as migration toward antigen. These effects were reversed by serum withdrawal, yet the increased formation and secretion of S1P were the same as in the presence of serum. Nonetheless, serum increased localization of SphK1 at the plasma membrane. This restricted formation of S1P induced internalization and desensitization of S1P receptors on the surface of mast cells as determined by confocal immunofluorescence microscopy, aberrant S1P receptor signaling, and lack of S1P receptor coupling to G proteins. Serum starvation, which significantly reduced membrane-associated SphK1 activity, restored S1P receptor functions. Our results have important implications for mast-cell migration and degranulation as well as for the biologic functions of the S1P receptors on cells that are circulating in the bloodstream. (Blood. 2005;105:4736-4742)
Phenotypic characterization of the human myeloma cell growth fraction
Authors: Robillard Nelly , Pellat-Deceunynck Catherine , Bataille Régis 
Published: March 2005

AbstractIn this study we quantified the proliferation rate of normal and malignant plasma cells (PCs) by ex vivo incorporation of 5-bromo-2′-deoxyuridine (BrdU; labeling index, LI) using flow cytometry. We show that all bone marrow PCs, either normal or malignant, include a subset of proliferating PCs present within the CD45bright fraction. Indeed, medullary normal and malignant PCs were always heterogeneous for CD45 expression, and proliferation was always restricted primarily to the CD45bright compartment. Moreover, an inverse correlation was found between LI or CD45 and B-cell lymphoma 2 (Bcl-2) in both malignant and normal PCs, the most proliferating CD45bright PCs have the lowest Bcl-2 expression. We investigated expression of molecules of interest in multiple myeloma (MM)—that is, CD138, CD19, CD20, CD27, CD28, CD56, and CD11a—to further characterize the CD45bright fraction. Among all of these molecules, only CD11a was exclusively expressed by CD45bright proliferating myeloma cells. In conclusion, proliferating myeloma cells are characterized by the specific CD45bright CD11apos Bcl-2low phenotype. (Blood. 2005;105:4845-4848)