bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing Number Field Isomorphisms from *-Isomorphisms of Certain Crossed Product C*-Algebras
Authors: Bruce Chris , Takeishi Takuya 
Published: January 2024

AbstractWe prove that the class of crossed product C*-algebras associated with the action of the multiplicative group of a number field on its ring of finite adeles is rigid in the following explicit sense: Given any *-isomorphism between two such C*-algebras, we construct an isomorphism between the underlying number fields. As an application, we prove an analogue of the Neukirch–Uchida theorem using topological full groups, which gives a new class of discrete groups associated with number fields whose abstract isomorphism class completely characterises the number field.
Dabigatran-related serious medication errors: an analysis using data from VigiBase
Authors: Zhang Qingxia , Ding Qian , Yue Qun-Ying 
Published: January 2024

Abstract
Objective
To analyze the serious medication errors (MEs) on dabigatran, and their related factors, in order to avoid or reduce the occurrence of adverse events.

Methods
Serious MEs related to dabigatran were extracted from the WHO global database of reported potential side effects of medicinal products (VigiBase) by using “Medication errors and other product use errors and issues” High Level Group Term (HLGT) of the international Medical Dictionary for Regulatory Activities (MedDRA). Well-documented reports, vigiGrade completeness score ≥ 0.80, or with an informative narrative were analyzed with a focus on the clinical features of the cases. The PCNE Classification for drug-related problems (DRP) was used to classify medication errors in our analysis of cases.

Results
Until January 26, 2020, there were 453 cases with serious MEs related to dabigatran in VigiBase, and 113 were well-documented. Among these, 69 patients (61%) were hospitalized or had prolonged hospitalization, 16 (14%) had life-threatening events, and 12 (11%) died. The MEs occurred in the prescription phase in 77 cases, in administration in 35, and at the dispensing stage in one case. The MEs in prescription were related to a drug selection error in 44 cases (24 concerning contraindications and 20 drug interactions) and to dose error in 33 cases (17 with excessive dose; eight with insufficient frequency; four had an incorrect time; in three, the dose was too low; and in one, too frequent). The MEs in administration were medical-staff-related errors in five cases (three with wrong administration route, one administration omission, and one overdose), patient-related errors in 28 (14 insufficient dose or no administration, seven improper drug storage, four wrong administration method, and three over prescribed dose), and other errors in two (without efficacy monitoring). The dispensing error of a wrong drug strength occurred in a pharmacy. The main adverse events in the 113 patients were haemorrhage in 57 cases (50%) and ischemia in 29 cases (26%).

Conclusion
Based on the analysis of reports in VigiBase, serious MEs related to dabigatran mainly occurred during prescription and administration. Although the incidence of MEs with clinical consequences in the use of dabigatran cannot be determined, attention should be paid to selection of the appropriate dose to a right patient in the prescription, and to patient compliance and storage in drug administration. The patient harm mainly manifested itself as bleeding or ischemia including fatal outcome in rare patients.
Transcriptomic analyses of Vibrio parahaemolyticus under the phenyllactic acid stress
Authors: Lin Yilin , Fang Meimei , Liu Jun , Zhang Yehui , Yu Yigang 
Published: January 2024

Abstract
Phenyllactic acid (PLA) generally recognized as a natural organic acid shows against Vibrio parahaemolyticus activity. In this study, V. parahaemolyticus ATCC17802 (Vp17802) was cultured under the stress of 1/2MIC PLA, and then the antibacterial mechanisms were explored via transcriptomics. The minimum inhibitory concentration (MIC) of PLA against Vp17802 was 3.2 mg/mL, and the time-kill analysis resulted that Vp17802 was inhibited. PLA was able to destroy the bacterial membrane, leading to the leakage of intracellular substances and decline of ATP levels. The RNA-sequencing analysis results indicated that 1616 significantly differentially expressed genes were identified, among which 190 were up-regulated and 1426 were down-regulated. Down-regulation of the icd2 gene in the TCA cycle mediates blockage of tyrosine metabolic, arginine biosynthesis, and oxidative phosphorylation, causing insufficient energy supply of Vp17802. Moreover, PLA could cause amino acids, metal ions, and phosphate transporters to be blocked, affecting the acquisition of nutrients. The treatment by PLA altered the expression of genes encoding functions involved in quorum sensing, flagellar assembly, and cell chemotaxis pathway, which may be interfering with the biofilm formation in Vp17802, reducing cell motility. Overall, 1.6 mg/mL PLA inhibited the growth of Vp17802 by disrupting to uptake of nutrients, cell metabolism, and the formation of biofilms. The results suggested a new direction for exploring the activity of PLA against Vp17802 and provided a theoretical basis for bacterial pathogen control in the food industry.

Key points
•RNA sequencing was carried out to indicate the antibacterial mechanism of Vp17802.
•The icd2 gene in the TCA cycle mediates blockage of metabolic of Vp17802.
•The biofilm formation has interfered with 1.6 mg/mL PLA, which could reduce cell motility and virulence.

Graphical Abstract
Isolated massive pleural effusion as a manifestation of chronic graft versus host disease successfully treated with corticosteroid
Authors: Masuda Yasutaka , Yamazaki Sho , Honda Akira , Masamoto Yosuke , Kurokawa Mineo 
Published: January 2024

AbstractIsolated pleural effusion is a rare manifestation of chronic graft versus host disease (cGVHD) after hematopoietic stem cell transplantation (HSCT). We herein report a 58-year-old woman presenting with massive pleural effusion approximately 1 year after allogeneic HSCT, who was successfully treated with corticosteroid. She had discontinued tacrolimus approximately 1 month before she presented with pleural effusion, which was attributed to cGVHD after a thorough exclusion process. This case illustrates a unique manifestation of atypical cGVHD and highlights the need for prompt therapy initiation.
The crosstalk between subjective fibromyalgia, mental health symptoms and the use of over-the-counter analgesics in female Syrian refugees: a cross-sectional web-based study
Authors: Gammoh Omar , Aljabali Alaa A. A. , Tambuwala Murtaza M. 
Published: January 2024

AbstractSuboptimal fibromyalgia management with over-the-counter analgesics leads to deteriorated outcomes for pain and mental health symptoms especially in low-income countries hosting refugees. To examine the association between the over-the-counter analgesics and the severity of fibromyalgia, depression, anxiety and PTSD symptoms in a cohort of Syrian refugees. This is a cross-sectional study. Fibromyalgia was assessed using the patient self-report survey for the assessment of fibromyalgia. Depression was measured using the Patient Health Questionnaire-9, insomnia severity was measured using the insomnia severity index (ISI-A), and PTSD was assessed using the Davidson trauma scale (DTS)-DSM-IV. Data were analyzed from 291. Among them, 221 (75.9%) reported using acetaminophen, 79 (27.1%) reported using non-steroidal anti-inflammatory drugs (NSAIDs), and 56 (19.2%) reported receiving a prescription for centrally acting medications (CAMs). Fibromyalgia screening was significantly associated with using NSAIDs (OR 3.03, 95% CI 1.58–5.80, p = 0.001). Severe depression was significantly associated with using NSAIDs (OR 2.07, 95% CI 2.18–3.81, p = 0.02) and CAMs (OR 2.74, 95% CI 1.30–5.76, p = 0.008). Severe insomnia was significantly associated with the use of CAMs (OR 3.90, 95% CI 2.04–5.61, p < 0.001). PTSD symptoms were associated with the use of CAMs (β = 8.99, p = 0.001) and NSAIDs (β = 10.39, p < 0.001). Improper analgesics are associated with poor fibromyalgia and mental health outcomes, prompt awareness efforts are required to address this challenge for the refugees and health care providers.
Identifying climate memory impacts on climate network analysis: a new approach based on fractional integral techniques
Authors: Wei Zhichao , Yuan Naiming 
Published: January 2024

AbstractClimate network (CN) analysis has shown great potential in detecting early warning signals for major climate events, but it is still challenging to reveal the underlying mechanisms. One possible reason for this issue is related to the ubiquitous climate memory, which may affect the calculations of links in climate networks, and further hinder us from a clear judgment on the sources of the early warning signal. Here in this study, we aim at identifying the climate memory impacts on the CN analysis. Combining with the Fractional Integral Statistical Model (FISM), we proposed a new approach named as CN-FISM. With FISM, one can extract the climate memory component and modify the considered time series into new series with a given length of memory preserved. By repeating the CN analysis, one thus can quantify the impacts of climate memory. We employed this approach to a recent CN analysis on the Pacific Decadal Oscillation (PDO) phase change. By comparing the CN results based on data with different memory lengths preserved, we found the climate memory within timescale of 2 years plays an important role in the arising of the early warning signal for the PDO phase change. This finding suggests that some physical processes on timescale of 2 years may be crucial for the PDO phase change, according to which one may better understand its underlying mechanisms. Compared with the current Pearson correlation-based CN approach, the CN-FISM offers the potential of improved interpretability of the CN results.
Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6
Authors: Leung Tsz Chui Sophia , Fields Eviatar , Rana Namrata , Shen Ru Yi Louisa , Bernstein Alexandra E. , Cook Anna A. , Phillips Daniel E. , Watt Alanna J. 
Published: January 2024

AbstractSpinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that manifests in midlife and progressively worsens with age. SCA6 is rare, and many patients are not diagnosed until long after disease onset. Whether disease-causing cellular alterations differ at different disease stages is currently unknown, but it is important to answer this question in order to identify appropriate therapeutic targets across disease duration. We used transcriptomics to identify changes in gene expression at disease onset in a well-established mouse model of SCA6 that recapitulates key disease features. We observed both up- and down-regulated genes with the major down-regulated gene ontology terms suggesting mitochondrial dysfunction. We explored mitochondrial function and structure and observed that changes in mitochondrial structure preceded changes in function, and that mitochondrial function was not significantly altered at disease onset but was impaired later during disease progression. We also detected elevated oxidative stress in cells at the same disease stage. In addition, we observed impairment in mitophagy that exacerbates mitochondrial dysfunction at late disease stages. In post-mortem SCA6 patient cerebellar tissue, we observed metabolic changes that are consistent with mitochondrial impairments, supporting our results from animal models being translatable to human disease. Our study reveals that mitochondrial dysfunction and impaired mitochondrial degradation likely contribute to disease progression in SCA6 and suggests that these could be promising targets for therapeutic interventions in particular for patients diagnosed after disease onset.
Biomechanical properties measured with dynamic Scheimpflug analyzer in central serous chorioretinopathy
Authors: Aoki Shuichiro , Asaoka Ryo , Azuma Keiko , Kitamoto Kohdai , Ueda Kohei , Inoue Tatsuya , Obata Ryo 
Published: January 2024

Abstract
Purpose
Recent evidence suggests that venous congestion at the vortex vein significantly contributes to the development of central serous chorioretinopathy (CSCR), and sclera is observed to be thicker in affected eyes. This study aims to investigate whether eyes with CSCR exhibit stiff corneas, measured using Corneal Visualization Scheimflug Technology (Corvis ST), which may serve as an indicator of scleral stiffness.

Methods
This retrospective case–control study comprises 52 eyes from 33 patients diagnosed with CSCR and 52 eyes from 32 normal controls without CSCR. We compared biomechanical parameters measured with Corvis ST and anterior scleral thickness measured using anterior segment swept-source optical coherence tomography between the two groups.

Results
Age, sex, axial length, intraocular pressure, and central corneal thickness showed no significant differences between the two groups (p > 0.05, linear mixed model). Three biomechanical parameters—peak distance, maximum deflection amplitude, and integrated inverse radius—indicated less deformability in CSCR eyes compared to control eyes. The stress–strain index (SSI), a measure of stiffness, and anterior scleral thickness (AST) at temporal and nasal points were significantly higher in the CSCR eyes. SSI and AST were not correlated, yet both were significantly and independently associated with CSCR in a multivariate logistic regression model.

Conclusions
Eyes affected by CSCR have stiffer corneas, irrespective of thicker scleral thickness. This suggests that stiffer sclera may play a role in the pathogenesis of CSCR.
Insights from the preimaginal morphology of the constans species-group, to reveal novel morphological patterns of the Merodon albifrons-evolutionary lineage (Diptera, Syrphidae)
Authors: Aracil Andrea , Andrić Andrijana , Rojo Santos , Shparyk Viktor , Mishustin Ruslan , Popov Grigory , Radenković Snežana , Vujić Ante , Pérez-Bañón Celeste 
Published: January 2024

AbstractMerodon triangulum Vujić, Radenković & Hurkmans, 2020 is a European endemic hoverfly species belonging to Merodon constans species-group, inside albifrons-lineage. The distribution of this species is known to be mostly central Europe and Balkan peninsula and it has been categorized as Near Threatened in the European IUCN red list of hoverflies; this paper cites the species for the first time in Ukraine (western Ukraine, specifically). In the present study, the preimaginal stages of this species are described and figured using Scanning Electron Microscopy. The material used for the descriptions were larvae collected in Ukraine and Serbia feeding inside underground storage organs of the spring snowflake Leucojum vernum L., 1753. This morphological description constitutes the first one inside the constans species-group, and the sixth description of the albifrons-lineage, in which there is only one species-group left to have at least one species of the preimaginal stages described (i.e., ruficornis species-group). The descriptions were compared with the rest available of the genus, stating the diagnostical characters of the present species and the shared characters inside the lineage. The novel information provided on the trophic interaction between M. triangulum larvae and Leucojum bulbs is stated for the first time and further supports the association of the constans species-group with the underground storage organs of snowflakes and snowdrops (Galantheae) in their role as host plants.
Endoclip combined with colonic transendoscopic enteral tubing: a new approach for managing iatrogenic colonoscopy perforation
Authors: Jiang Xiaomeng , Ni Chunhua , Tabak Fatema , Li Yi , Zhang Faming 
Published: January 2024

Abstract
Background
Iatrogenic colonoscopy perforation (ICP) is a rare but most serious complication during colonoscopy investigation. However, endoscopic closure plays an important role in the dealing with ICP with the development of endoscopic techniques presently, there are still some portion of patients transferred to surgery.

Methods
Once a perforation was detected, endoclips were used to closed the defect of the colon. Then a colonic TET was planted inside the colon. The terminal end of the TET was put proximally to or near the location of the perforation. Then gas and fluid was sucked out through the TET with a syringe every 4 h.

Results
Three cases were treated with endoclip closure and colonic TET drainage. Case 1 was caused by urgent immediate perforation during routine colonoscopy, case 2 was delayed perforation after snare resection, and case 3 was ESD-related perforation. All patients got healed, no one transferred to surgery.

Conclusions
A combination of endoclip closure and colonic TET drainage might be an easy and potential method in the dealing with different types of ICP. This study may offer a novel paradigm for addressing endoscopy-related intestinal perforations.
Association of serum CTRP4 levels with vascular endothelial function in patients with type 2 diabetes mellitus: CTRP4 ameliorating inflammation, proliferation and migration in human umbilical vein endothelial cells
Authors: Gao Jie , Rouzi Mai Re YanMu , Zhang Huihui , Cai Xinghua , Xu Bilin , Lu Jun , Lei Tao 
Published: January 2024

Abstract
Objective
We investigated the correlation between serum C1q/TNF-related protein 4 (CTRP4) level and flow-mediated dilation (FMD) in patients with type 2 diabetes mellitus (T2DM), and evaluated the biological effects of CTRP4 on human umbilical vein endothelial cells (HUVECs).

Methods
A group of 165 patients diagnosed with T2DM were included in this study. Endothelial function was measured with the examination of brachial artery FMD. ELISA kit was used to measure the levels of CTRP4 in serum. HUVECs were stimulated with recombinant CTRP4 protein to assess its biological functions.

Results
The levels of CTRP4 showed a significant variation among three groups based on FMD tertiles (p = 0.001). What’s more, FMD had a significant difference among three CTRP4 tertile groups (p < 0.05) and was negatively related to serum CTRP4 levels (r = −0.270, p < 0.001). In T2DM patients, logistic regression analysis demonstrated that CTRP4 was the primary influence factor of low FMD (p < 0.01). In receiver operating characteristic curve analysis, the area under the curve of CTRP4 for predicting low FMD was 0.66 (95%CI 0.58–0.75). When stimulated HUVECs with recombinant CTRP4 protein, we found that CTRP4 could concentration-dependently ameliorate proliferation and migration of HUVECs in wounding healing and transwell assay. This protein could also decrease the expression of IL-6 and TNF-α and promote the release of NO in HUVEC supernatants, with suppression of NF-κB and STAT3 phosphorylation.

Conclusions
Serum CTRP4 concentrations were negatively associated with FMD. CTRP4 alleviated proliferation, migration and inflammation in HUVECs through the suppression of NF-κB and STAT3 signaling pathways.
Protective factors associated with resilience among unaccompanied refugee minors after settling in Norway: a matched cross-sectional study
Authors: Heimli Oda Marie , Kvestad Ingrid , Bøe Tormod , Sayyad Nawar , Nilsen Sondre Aasen , Randal Sølve , Askeland Kristin Gärtner 
Published: January 2024

AbstractThis study aimed to examine protective factors associated with resilience among unaccompanied refugee minors in comparison to their Norwegian peers and to examine associations between resilience factors and characteristics related to positive outcomes among unaccompanied minors. Data stem from the Pathways to Independence study conducted in Bergen municipality, Norway in 2018–2019 where 81 unaccompanied minors aged 15–20 participated (83.3% male; 80% response rate). An age- and sex-matched control group of 324 adolescents was retrieved from the youth@hordaland study conducted in Norway in 2012. Resilience factors were assessed by the Resilience Scale for Adolescents. Unaccompanied minors reported lower scores on Goal Orientation (d = 0.4), Social Competence (d = 0.4), and Social Support (d = 0.7) compared to Norwegian adolescents. Being male was associated with lower scores on Goal Orientation (standardized mean difference [SMD] = − 0.9) and Social Support (SMD = − 0.9) among unaccompanied minors, while being in frequent contact with family in the home country was associated with higher scores on all resilience factors (SMD range = 0.6–1.1). The number of leisure activities was associated with Social Competence (SMD = 0.22). There were no significant associations between the resilience factors and amount of support in the living arrangements or contact with the child welfare services. Unaccompanied minors reported fewer resilience factors compared to Norwegian adolescents, indicating that they may have different needs compared to other adolescents. Our study also suggests that frequent contact with family in the home country may be important to bolster positive development for unaccompanied minors after settlement.
Prevalence of antibiotic-resistant Acinetobacter spp. on soil and crops collected from agricultural fields in South Korea
Authors: Son Su Min , Ahn Eunbyeol , Ahn Sojin , Cho Seoae , Ryu Sangryeol 
Published: January 2024

AbstractThe emergence of antibiotic resistance in Acinetobacter spp. is a rising public health concern worldwide. The objective of this study was to investigate the prevalence of antibiotic-resistance genes and the virulence of Acinetobacter spp. isolated from soil and crops obtained from agricultural fields in South Korea. Eight Acinetobacter spp. isolates carried various antibiotic resistance genes, such as emrAB (100%), cat/craA (100%), and aadA gene (87.5%). Minimum inhibitory concentration (MIC) analysis revealed that strains harboring antibiotic resistance genes exhibited high resistance to the respective antibiotics, such as colistin, chloramphenicol, and streptomycin. Interestingly, most of these isolates had high capability of biofilm formation and swarming motility, along with faster growth rates. Taken together, our study demonstrated that antibiotic-resistant Acinetobacter isolated from agricultural settings in South Korea not only frequently carries antibiotic resistance genes but also has virulence-related traits.