bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Status of Hedgehog Signaling Inhibitors
Authors: Wang Xiaotang , Wang Tian , Song Xiaona , Gao Jiping , Xu Guoqiang , Ma Yunhui , Song Guohua 
Published: January 2024

Abstract:
The Hedgehog (Hh) signaling pathway plays a crucial role in diverse biological pro-cesses such as cell differentiation, proliferation, senescence, tumorigenesis, malignant transfor-mation, and drug resistance. Aberrant Hh signaling, resulting from mutations and excessive acti-vation, can contribute to the development of various diseases during different stages of biogenesis and development. Moreover, it has been linked to unfavorable outcomes in several human can-cers, including basal cell carcinoma (BCC), multiple myeloma (MM), melanoma, and breast can-cer. Hence, the presence of mutations and excessive activation of the Hh pathway presents obsta-cles and constraints in the realm of cancer treatment. Extant research has demonstrated that small molecule inhibitors are regarded as the most effective therapeutic approaches for targeting the Hh pathway in contrast to traditional chemotherapy and radiotherapy. Consequently, this review fo-cuses on the present repertoire of small molecule inhibitors that target various components of the Hh pathway, including Hh ligands, Ptch receptors, Smo transmembrane proteins, and Gli nuclear transcription factors. This study provides a comprehensive analysis of small molecules' structural and functional aspects in the preclinical and clinical management of cancer. Additionally, it elu-cidates the obstacles encountered in targeting the Hh pathway for human cancer therapy and pro-poses potential therapeutic approaches.
Formulation, Design, Optimization, and Characterization of Novel
Long-acting Injectable Dosage Form of Anti-psychotic Drug
Authors: Patel Niraj , Patel Rakesh , Dharamsi Abhay 
Published: January 2024

Background:
The current research aimed to create and analyze a new long-acting Brexpiprazole
(BRX) injectable for successful anti-psychotic drug therapy in order to decrease dosage
frequency and increase patient compliance. Systems for drug transport to particular body sites or
regulating release rates with accuracy are known as drug delivery systems (DDS). By affixing the
drug to a carrier particle like liposomes, nanoparticles, microspheres, etc., which modifies the drug's
absorption and release properties, using carrier technology, drugs may be delivered in an intelligent
manner.

Methods:
Utilizing Resomer RG 502 H and RESOMER® RG 752 H extended-release Polymer, Using
a quasi-emulsion solvent diffusion, microspheres were made, and emulsification and solvent
evaporation process.

Results:
The produced microspheres were assessed for stability tests, in vitro drug release, flow characteristics,
and drug entrapment efficiency. FTIR experiments were used to establish how well the
drug excipients worked together. The acarbose microspheres that were created had an 89.9 to 96.1
percent drug entrapment efficiency. The impact of factors like polymer content on medication release
was studied. The Stability study of the formulation was carried out under different conditions, and
data were established. Comparative pharmacokinetic studies between marketed oral formulation and
Brexpirazole microsphere test formulations in Wistar/SD Rats were carried out and concluded.

Conclusion:
Brexpiprazole (BRX) novel long-acting injectable formulation, could be used effectively
for the treatment of mentally challenged anti-psychotic patients worldwide.
A Correlation Study to Comprehend the SAR-CoV-2 Viral Load, Antiviral
Antibody Titer, and Severity of COVID-19 Symptoms Post-infection
Amongst the Vaccinated Population in Kamrup District of As sam,
Northeast India
Authors: Patra Aparup , Bala Asis , Khan Mojibur R. , Mukherjee Ashis K. 
Published: January 2024

Background:
As per the recommendation of the United States Food and Drug
Administration, more research is needed to determine the antibody titer against COVID-19
vaccination.

Objective:
The study aimed to understand the relationship between the antibody titer to the demographics,
infection severity, and cycle threshold (CT) values of confirmed COVID-19 patients.

Methods:
Initially, we obtained consent from 185 populations and included sixty RT-PCRpositive
COVID-19 patients from Kamrup District in the Northeast State of Assam, India. The
vaccination status was recorded and tested for the level of serum immunoglobulin (IgG). The CT
values, gender, and clinical symptoms-based scoring (CSBS) correlated with their IgG value.

Results:
Around 48% of participants gained an antibody titer more than the threshold value and
showed CT values between 18-25. Moreover, the maximum distributed score above the average
was found between the CT values 18-25.

Conclusion:
The IgG titer value differs significantly amongst the vaccinated population, which
may depend upon their genetic and demographic variability.
Downregulation of Serum miR-133b and miR-206 Associate with Clinical
Outcomes of Progression as Monitoring Biomarkers for Metastasis
Colorectal Cancer Patients
Authors: Wanram Surasak , Klaewkla Namphon , Pinyosri Parichart 
Published: January 2024

Background:
Colorectal cancer (CRC) is the third most common cancer in the world. Non-coding RNAs or microRNAs (miRNAs; miRs) biomarkers can play a role in cancer carcin-ogenesis and progression. Specific KRAS and EGFR mutation are associated with CRC develop-ment playing a role in controlling the cellular process as epigenetic events. Circulating serum miRs can serve for early diagnosis, monitoring, and prognosis of CRC as biomarkers but it is still unclear, clinically.

Objective:
To determine potential biomarkers of circulating serum miR-133b and miR-206 in CRC patients

Methods:
Bioinformatic prediction of microRNA was screened followed by TargetScanHu-man7.2, miRTar2GO, miRDB, MiRanda, and DIANA-microT-CDS. Forty-four CRC serum (19 locally advanced, 23 distant advanced CRC) and 12 normal serum samples were subsequently extracted for RNA isolation, cDNA synthesis, and miR validation. The candidate circulating se-rum miR-133b and miR-206 were validated resulting in a relative expression via quantitative RT-PCR. Relative expression was normalized to the spike-internal control and compared to normal samples as 1 using the 2-ΔΔCt method in principle.

Results:
Our results represented 9 miRs of miR-206, miR-155-5p, miR-143-3p, miR-193a-3p, miR-30a-5p, miR-30d-5p, miR-30e-5p, miR-543, miR-877-5p relate to KRAS-specific miRs, whereas, 9 miRs of miR-133b, miR-302a-3p, miR-302b-3p, miR-302d-3p, miR-302e, miR-520a-3p, miR-520b, miR-520c-3p and miR-7-5p relevance to EGFR-specific miRs by using the bioin-formatic prediction tools. Our results showed a decreased expression level of circulating serum miR-133b as well as miR-206 associating with CRC patients (local and advanced metastasis) when compared to normal (P < 0.05), significantly.

Conclusion:
The circulating serum miR-133b and miR-206 can serve as significant biomarkers for monitoring the clinical outcome of progression with metastatic CRC patients. Increased drug-responsive CRC patients associated with crucial molecular intervention should be further ex-plored, clinically.
Assessing the Effectiveness of STAPP@Work, a Self-Management Mobile App, in Reducing Work Stress and Preventing Burnout: Single-Case Experimental Design Study
Authors: Demirel Sevda , Roke Yvette , Hoogendoorn Adriaan W , Hoefakker Jamie , Hoeberichts Kirsten , van Harten Peter N 
Published: January 2024

Background
Work-related stress and burnout remain common problems among employees, leading to impaired health and higher absenteeism. The use of mobile health apps to promote well-being has grown substantially; however, the impact of such apps on reducing stress and preventing burnout is limited.

Objective
This study aims to assess the effectiveness of STAPP@Work, a mobile-based stress management intervention, on perceived stress, coping self-efficacy, and the level of burnout among mental health employees.

Methods
The study used a single-case experimental design to examine the use of STAPP@Work among mental health employees without a known diagnosis of burnout (N=63). Participants used the app for 1 week per month repeatedly for a period of 6 months. Using a reversal design, the participants used the app 6 times to assess replicated immediate (1 week after use) and lasting (3 weeks after use) effects. The Perceived Stress Scale, the Coping Self-Efficacy Scale, and the Burnout Assessment Tool were used to measure the outcomes. Linear mixed models were used to analyze the data.

Results
After 6 months of app use for 1 week per month, the participants showed a statistically significant decrease in perceived stress (b=–0.38, 95% CI –0.67 to –0.09; P=.01; Cohen d=0.50) and burnout symptoms (b=–0.31, 95% CI –0.51 to –0.12; P=.002; Cohen d=0.63) as well as a statistically significant improvement in problem-focused coping self-efficacy (b=0.42, 95% CI 0-0.85; P=.049; Cohen d=0.42). Long-term use of the app provided consistent reductions in burnout symptoms over time, including in the level of exhaustion and emotional impairment.

Conclusions
The use of an app-based stress management intervention has been shown to reduce burnout symptoms and enhance coping self-efficacy among mental health workers. Prevention of burnout and minimization of work-related stress are of utmost importance to protect employee health and reduce absenteeism.
Identifying Unmet Needs in Major Depressive Disorder Using a Computer-Assisted Alternative to Conventional Thematic Analysis: Qualitative Interview Study With Psychiatrists
Authors: Worthington Michelle A , Christie Richard H , Masino Aaron J , Kark Sarah M 
Published: January 2024

Background
The development of digital health tools that are clinically relevant requires a deep understanding of the unmet needs of stakeholders, such as clinicians and patients. One way to reveal unforeseen stakeholder needs is through qualitative research, including stakeholder interviews. However, conventional qualitative data analytical approaches are time-consuming and resource-intensive, rendering them untenable in many industry settings where digital tools are conceived of and developed. Thus, a more time-efficient process for identifying clinically relevant target needs for digital tool development is needed.

Objective
The objective of this study was to address the need for an accessible, simple, and time-efficient alternative to conventional thematic analysis of qualitative research data through text analysis of semistructured interview transcripts. In addition, we sought to identify important themes across expert psychiatrist advisor interview transcripts to efficiently reveal areas for the development of digital tools that target unmet clinical needs.

Methods
We conducted 10 (1-hour-long) semistructured interviews with US-based psychiatrists treating major depressive disorder. The interviews were conducted using an interview guide that comprised open-ended questions predesigned to (1) understand the clinicians’ experience of the care management process and (2) understand the clinicians’ perceptions of the patients’ experience of the care management process. We then implemented a hybrid analytical approach that combines computer-assisted text analyses with deductive analyses as an alternative to conventional qualitative thematic analysis to identify word combination frequencies, content categories, and broad themes characterizing unmet needs in the care management process.

Results
Using this hybrid computer-assisted analytical approach, we were able to identify several key areas that are of interest to clinicians in the context of major depressive disorder and would be appropriate targets for digital tool development.

Conclusions
A hybrid approach to qualitative research combining computer-assisted techniques with deductive techniques provides a time-efficient approach to identifying unmet needs, targets, and relevant themes to inform digital tool development. This can increase the likelihood that useful and practical tools are built and implemented to ultimately improve health outcomes for patients.
Digital Storytelling Intervention for Enhancing the Social Participation of People With Mild Cognitive Impairment: Co-Design and Usability Study
Authors: Zhu Di , Al Mahmud Abdullah , Liu Wei 
Published: January 2024

Background
Community-based social participation has shown promise in delaying cognitive decline in older adults with mild cognitive impairment (MCI) who are at risk of developing dementia. Although group storytelling interventions have proven effective, the need for a skilled workforce to support people with MCI can limit broader community implementation. Technology-based interventions may offer a solution to this limitation by replicating the abilities of therapists.

Objective
This study aims to co-design a digital storytelling intervention and evaluate its usability.

Methods
This co-design process involved 3 stages, engaging people with MCI (n=12), their caregivers (n=4), and therapists (n=5) in Beijing, China. In the first stage, we used card sorting and voting methods to identify potential incentives for social participation and target the specific abilities that people with MCI wanted to enhance. In the second stage, we conducted brainstorming sessions with people with MCI and their caregivers to identify the potential features of a digital storytelling application named Huiyou (“meeting new friends” in Chinese). Finally, we assessed Huiyou’s usability with people with MCI and therapists, leading to iterative improvements based on the usability findings.

Results
We uncovered a crucial link between boosting the self-confidence of people with MCI and their ability to address social participation challenges. Notably, we identified memory improvement and enhanced language expression as key factors for effective communication with grandchildren. Subsequently, participants suggested features and interfaces to address these challenges, leading to the development of Huiyou, a group-based digital storytelling application featuring functions such as generating story materials, conducting memory retrieval activities, and sharing stories. It received an “excellent” rating in the User Experience Questionnaire benchmark, displaying high levels of attractiveness, dependability, stimulation, and novelty. People with MCI achieved an average task completion rate of 87% (n=19; SD 0.13) of the 22 tasks. However, feedback from people with MCI and therapists highlighted usability issues in navigation, activity management, user interface, and feature optimization, indicating a need for improved accessibility and efficiency.

Conclusions
The co-design approach contributed to developing the Huiyou prototype, supporting community-based social participation. User feedback highlighted the potential of Huiyou to enhance well-being and facilitate meaningful social interactions while maintaining crucial existing relationships.
Kajian Penerapan Prosedur Pelayanan di Restoran Ubud
Authors: Masih Ni Luh Nukari , Pratiwi Komang Trisna 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui Standar Prosedur pelayanan di Mr.Wayan Restoran Wapa di Ume Ubud dan untuk mengetahui standart prosedur yang sudah diterapakan di restoran tersebut. Alat ukur yang digunakan untuk mengetahui tujuan dari penelitian ini adalah prosedur pelayanan yang berlaku di Mr.Wayan Restoran Wapa di Uma Ubud. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Teknik pengumpulan data dilakukan dengan cara wawancara, observasi, dokumentasi. Selanjutnya data yang didapatkan diolah dengan menguraikan permasalahan yang ada di lapangan untuk kemudian dibandingkan dengan prosedur pelayanan yang berlaku. Hasil penelitian ini menunjukkan bahwa ada beberapa standar operasional yang tidak diterapkan oleh karyawan. Evaluasi serta pelatihan perlu dilakukan lagi agar dapat membuat penerapan menjadi lebih baik dari sebelumnya.

This study aims to determine the standard of service procedures at Mr. Wayan Wapa Restaurant in Ume Ubud and to find out the standard procedures that have been applied in the restaurant. The measuring instrument used to determine the purpose of this research is the service procedure that applies at Mr. Wayan Wapa Restaurant in Uma Ubud. The data analysis technique used in this research is descriptive qualitative. Data collection techniques were carried out by means of interviews, observations, and documentation. Furthermore, the data obtained is processed by describing the problems that exist in the field and then compared with the applicable service procedures. The results of this study indicate that there are several operational standards that are not applied by employees. Evaluation and practice need to be done again in order to make the implementation better than before.
Penerapan Standar Operasional Prosedur Pelayanan Kamar Occupied oleh Room Attendant
Authors: Titiksa Putu Dandin Karya , Wirawan Putu Eka 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui Standar Prosedur pelayanan di Mr.Wayan Restoran Wapa di Ume Ubud dan untuk mengetahui standart prosedur yang sudah diterapakan di restoran tersebut. Alat ukur yang digunakan untuk mengetahui tujuan dari penelitian ini adalah prosedur pelayanan yang berlaku di Mr.Wayan Restoran Wapa di Uma Ubud. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Teknik pengumpulan data dilakukan dengan cara wawancara, observasi, dokumentasi. Selanjutnya data yang didapatkan diolah dengan menguraikan permasalahan yang ada di lapangan untuk kemudian dibandingkan dengan prosedur pelayanan yang berlaku. Hasil penelitian ini menunjukkan bahwa ada beberapa standar operasional yang tidak diterapkan oleh karyawan. Evaluasi serta pelatihan perlu dilakukan lagi agar dapat membuat penerapan menjadi lebih baik dari sebelumnya.

This study aims to determine the standard of service procedures at Mr. Wayan Wapa Restaurant in Ume Ubud and to find out the standard procedures that have been applied in the restaurant. The measuring instrument used to determine the purpose of this research is the service procedure that applies at Mr. Wayan Wapa Restaurant in Uma Ubud. The data analysis technique used in this research is descriptive qualitative. Data collection techniques were carried out by means of interviews, observations, and documentation. Furthermore, the data obtained is processed by describing the problems that exist in the field and then compared with the applicable service procedures. The results of this study indicate that there are several operational standards that are not applied by employees. Evaluation and practice need to be done again in order to make the implementation better than before.
Modifikasi Produk Churros dengan Menggunakan Tepung Almond dan Tepung Gandum Utuh
Authors: Kurniawan Dea , Tunjungsari Komang Ratih 
Published: January 2024

Kuliner secara umum adalah kegiatan yang berhubungan dengan memasak atau aktivitas memasak. Pada umumnya Churros terbuat dari tepung terigu, dan beberapa orang ada yang memiliki alergi terhadap gluten dan adapun yang ingin memulai gaya hidup yang lebih sehat dengan mengurangi gluten. Dalam hal ini penulis ingin mengurangi kertergantungan tepung terigu dengan memberdayakan produk alternatif yang lebih sehat yaitu Tepung Gandum Utuh dan Tepung Almond guna mendukung tren gaya hidup yang lebih sehat yaitu diet gluten. Tujuan yang di capai adalah untuk mengetahui bagaimana kualitas rasa, aroma tekstur, warna, daya tahan dan minat calon konsumen. Eksperimen ini dilakukan dengan metode penelitian dan pengumpulan data. Hasil yang ditemukan pada penelitian ini adalah Churros dengan berbahan campuran 75% tepung almond dan 25% tepung gandum utuh unggul dalam seluruh aspek penelitian dibandingkan dengan churros berbahan dasar 100% tepung almond dan 50% tepung almond ditambah 50% tepung gandum utuh.

Culinary in general is an activity related to cooking or cooking activities. Churros are generally made from wheat flour, and there are some people who have an allergy to gluten and others who want to start a healthier lifestyle by reducing gluten. In this case the author wants to reduce dependence on wheat flour by empowering healthier alternative products, namely Whole Wheat Flour and Almond Flour to support the trend of a healthier lifestyle, namely the gluten diet. The goal is to find out how the quality of taste, aroma, texture, color, durability and interest of potential consumers. This experiment was conducted using research methods and data collection. The results found in this study were Churros made from a mixture of 75% almond flour and 25% whole wheat flour were superior in all aspects of the study compared to churros made from 100% almond flour and 50% almond flour plus 50% whole wheat flour.
Dampak Keberadaan Pabrik Tapioka Terhadap Kondisi Sosial Ekonomi Masyarakat Desa Jagang Kecamatan Blambangan Pagar
Authors: Harsya Erisa Pratiwi , Gitosaputro Sumayo , Silviyanti Serly , Nurmayasari Indah 
Published: January 2024

Tujuan penelitian untuk mengetahui dampak keberadaan pabrik tapioka terhadap kondisi sosial ekonomi di Desa Jagang Kecamatan Blambangan Pagar Kabupaten Lampung Utara. Penarikan sampel berjumlah 13 informan dipilih secara purposive sampling dengan metode snowball sampling. Waktu pengambilan data pada Bulan November 2021-Januari 2022. Teknik pengumpulan data yaitu observasi, wawancara, dokumentasi, serta triangulasi teknik dan triangulasi sumber. Dampak keberadaan pabrik tapioka terhadap kondisi sosial ekonomi dianalisis menggunakan deskriptif dan analisis model Miles dan Huberman. Hasil diperoleh dampak geo-fisik, kimia, dan biologi pabrik yaitu kerusakan kondisi jalan, kebisingan, pencemaran air, pencemaran udara pada periode tertentu, dan perubahan kualitas air permukaan. Dampak sosial-ekonomi yaitu kecemburuan sosial karena rendahnya penyerapan tenaga kerja dari masarakat sekitar, keresahan masyarakat, perbaikan mushola, peningkatan pendapatan dan perubahan struktur ekonomi. Dampak budaya yaitu upaya pelestarian seni tari tradisional. Dampak kesehatan masyarakat yaitu gangguan saluran pernafasan seperti influenza dan pemberian bantuan alat-alat kesehatan.

Kata kunci: dampak, pabrik, sosial-ekonomi, masyarakat.
Keberlanjutan Program Pekarangan Pangan Lestari Anggota Kelompok Wanita Tani di Provinsi Lampung
Authors: Novrianty Ely , Rangga Kordiyana K , Listiana Indah , Gitosaputro Sumaryo , Syarief Yuniar Aviati 
Published: January 2024

ABSTRACT

Development engaged in the food sector is one of the country's needs in increasing production and meeting needs, especially food. The Sustainable Food Yard Program (P2L) is one of the programs that is expected to be able to provide an increase in food production, especially for family consumption needs. The purpose of this study was to analyze the factors that influence the sustainability of the sustainable food garden program of women farmer groups in Lampung Province. The research method used is a quantitative method. The population in this study are members of the women's farmer group and stakeholders (stakeholders). Respondents studied amounted to 85 people. Data collection was carried out in June 2022. The data analysis method used was linear logistic regression analysis to determine the factors that influence program sustainability. The results showed that the level of sustainability of sustainable food gardens in Lampung Province was influenced by internal and external factors. Formal education, non-formal education, cosmopolitan level, number of family dependents, infrastructure, government support, market institutions and village nurseries and product marketing influence the level of sustainability of P2L in Lampung Province. Suggestions in this study are expected by certain parties, especially stakeholders and the government to be able to provide a forum and education for farmer women's groups in increasing knowledge and skills in managing and developing P2L programs.

Keywords: farmer women's group, sustainable food yard, sustainability