bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal study of the gut microbiota during the first three years of life: Links with problem behavior and executive functions at preschool age
Authors: Willemsen Yvonne , Ou Yangwenshan , Belzer Clara , Arias Vásquez Alejandro , Smidt Hauke , Beijers Roseriet , de Weerth Carolina 
Published: November 2023

AbstractEarly life is a sensitive period when microbiota-gut-brain interactions may have important impact on development. This study investigated the associations of the gut microbiota in the first three years of life (two, six, and 12 weeks, and one and three years) with problem behavior and executive functions in N = 64 three-year-old children. Higher relative abundance of Streptococcus at the age of two weeks, as well as its trajectory over time (including ages two, six and 12 weeks, and one and three years), was related to worse executive functions. Higher relative abundance of [Ruminococcus] torques group at the age of three years, as well as its trajectory from one to three years, was associated with less internalizing behavior. Besides, several robust age-specific associations were identified: higher Bifidobacterium relative abundance (age three years) was associated with more internalizing and externalizing issues; higher Blautia relative abundance (age three years) was linked to less internalizing behavior; and increased relative abundance of an unidentified Enterobacteriaceae genus (age two weeks) was related to more externalizing behavior. Our findings provide important longitudinal evidence that early-life gut microbiota may be linked to behavioral and cognitive development in low-risk children.
Cognitive behavioural therapy for depression and anxiety in a carer for two family members with dementia: a single case experimental design study
Authors: Falshaw Lawson , Clatworthy Leah 
Published: November 2023

AbstractBackground:Evidence suggests that cognitive behavioural therapy (CBT) can be a helpful approach for older adults experiencing anxiety and depression. Some research has suggested this is also the case for those caring for a family member with dementia. Little research has been conducted into the impact of CBT for older adults juggling the demands of caring for multiple family members with dementia.Aims:This case study aimed to evaluate the application of CBT to ‘Mrs P’, a 68-year-old client experiencing anxiety and depression whilst caring for two family members with dementia.Method:A single case experimental design study was conducted to assess the effectiveness of CBT formulation and intervention, including cognitive restructuring of unhelpful thoughts about caregiving and increasing engagement in pleasurable activities.Results:Mrs P’s depression and anxiety scores improved significantly throughout treatment, and she met her goal of being able to manage when caregiving activities go wrong during daily life.Conclusions:CBT may be a helpful approach to reducing anxiety and depression in dementia family caregivers.
The effect of a foreign language on cognitive reappraisal during exposure to a phobic stimulus
Authors: Ortigosa Isabel , Jaén Irene , Costumero Víctor , García-Palacios Azucena 
Published: November 2023

AbstractThis study investigates whether the cognitive reappraisal strategy is influenced by the participant's language (native/foreign) when confronting a fearful stimulus. Sixty participants with subclinical phobia of cockroaches were exposed to several phobic and neutral pictures while they used cognitive reappraisal in their native language or a foreign one. Electrodermal activity, pupil dilation, and self-reports of affective valence and arousal were collected. Results showed that participants in the foreign context were more effective at using reappraisal to reduce valence self-ratings compared to using no regulation. Also, participants in the foreign context showed greater pupil size when reappraising their emotions, compared to the non-regulation condition. Depending on the language, no differences were found for arousal self-reports or electrodermal activity when using reappraisal. These results suggest that using a foreign language could be advantageous in reducing the negative valence through reappraisal. Psychophysiological results are discussed in light of cognitive effort studies.
Engineering electrode interfaces for telecom-band photodetection in MoS2/Au heterostructures via sub-band light absorption
Authors: Hong Chengyun , Oh Saejin , Dat Vu Khac , Pak Sangyeon , Cha SeungNam , Ko Kyung-Hun , Choi Gyung-Min , Low Tony , Oh Sang-Hyun , Kim Ji-Hee 
Published: November 2023

AbstractTransition metal dichalcogenide (TMD) layered semiconductors possess immense potential in the design of photonic, electronic, optoelectronic, and sensor devices. However, the sub-bandgap light absorption of TMD in the range from near-infrared (NIR) to short-wavelength infrared (SWIR) is insufficient for applications beyond the bandgap limit. Herein, we report that the sub-bandgap photoresponse of MoS2/Au heterostructures can be robustly modulated by the electrode fabrication method employed. We observed up to 60% sub-bandgap absorption in the MoS2/Au heterostructure, which includes the hybridized interface, where the Au layer was applied via sputter deposition. The greatly enhanced absorption of sub-bandgap light is due to the planar cavity formed by MoS2 and Au; as such, the absorption spectrum can be tuned by altering the thickness of the MoS2 layer. Photocurrent in the SWIR wavelength range increases due to increased absorption, which means that broad wavelength detection from visible toward SWIR is possible. We also achieved rapid photoresponse (~150 µs) and high responsivity (17 mA W−1) at an excitation wavelength of 1550 nm. Our findings demonstrate a facile method for optical property modulation using metal electrode engineering and for realizing SWIR photodetection in wide-bandgap 2D materials.
MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis
Authors: Liu Shuzhen , Perez Preston , Sun Xue , Chen Ken , Fatirkhorani Rojin , Mammadova Jamila , Wang Zhigao 
Published: November 2023

AbstractMixed lineage kinase-like protein (MLKL) forms amyloid-like polymers to promote necroptosis; however, the mechanism through which these polymers trigger cell death is not clear. We have determined that activated MLKL translocates to the lysosomal membrane during necroptosis induction. The subsequent polymerization of MLKL induces lysosome clustering and fusion and eventual lysosomal membrane permeabilization (LMP). This LMP leads to the rapid release of lysosomal contents into the cytosol, resulting in a massive surge in cathepsin levels, with Cathepsin B (CTSB) as a significant contributor to the ensuing cell death as it cleaves many proteins essential for cell survival. Importantly, chemical inhibition or knockdown of CTSB protects cells from necroptosis. Furthermore, induced polymerization of the MLKL N-terminal domain (NTD) also triggers LMP, leading to CTSB release and subsequent cell death. These findings clearly establish the critical role of MLKL polymerization induced lysosomal membrane permeabilization (MPI-LMP) in the process of necroptosis.
Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy
Authors: Yang Li , Zhang Dan , Li Wenjing , Lin Hongbing , Ding Chendi , Liu Qingyun , Wang Liangliang , Li Zimu , Mei Lin , Chen Hongzhong , Zhao Yanli , Zeng Xiaowei 
Published: November 2023

AbstractThe treatment of diabetic wounds faces enormous challenges due to complex wound environments, such as infected biofilms, excessive inflammation, and impaired angiogenesis. The critical role of the microenvironment in the chronic diabetic wounds has not been addressed for therapeutic development. Herein, we develop a microneedle (MN) bandage functionalized with dopamine-coated hybrid nanoparticles containing selenium and chlorin e6 (SeC@PA), which is capable of the dual-directional regulation of reactive species (RS) generation, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), in response to the wound microenvironment. The SeC@PA MN bandage can disrupt barriers in wound coverings for efficient SeC@PA delivery. SeC@PA not only depletes endogenous glutathione (GSH) to enhance the anti-biofilm effect of RS, but also degrades GSH in biofilms through cascade reactions to generate more lethal RS for biofilm eradication. SeC@PA acts as an RS scavenger in wound beds with low GSH levels, exerting an anti-inflammatory effect. SeC@PA also promotes the M2-phenotype polarization of macrophages, accelerating wound healing. This self-enhanced, catabolic and dynamic therapy, activated by the wound microenvironment, provides an approach for treating chronic wounds.
Borate–pyran lean electrolyte-based Li-metal batteries with minimal Li corrosion
Authors: Kwon Hyeokjin , Kim Hongsin , Hwang Jaemin , Oh Wonsik , Roh Youngil , Shin Dongseok , Kim Hee-Tak 
Published: November 2023

AbstractEngineering liquid electrolytes for lithium (Li)-metal electrodes has been used to control the morphology of deposited Li in Li-metal batteries (LMBs). However, the Li corrosion problem remains unresolved, hindering the design of lean electrolytes for practical LMBs, which require the electrolyte/capacity (E/C) ratio to be 2 g Ah−1 or lower. Here we report a borate–pyran-based electrolyte to address the chronic Li-corrosion problem. We discovered that the borate–pyran electrolyte transforms large LiF crystallites in the solid–electrolyte interphase into fine crystalline or glassy LiF, which enhances the passivity of the Li/electrolyte interface by minimizing the permeation of electrolyte molecules into the solid–electrolyte interphase. LMBs assembled with the borate–pyran electrolyte, a high-nickel layered oxide cathode (3.83 mAh cm−2) and thin lithium (20 μm) delivered a high initial full-cell-level energy density (>400 Wh kg−1) and operated for 400 cycles with 70% capacity retention at an E/C ratio of 1.92 g Ah−1, 350 cycles with 73% capacity retention at 1.24 g Ah−1 and 200 cycles with 85% retention at 0.96 g Ah−1.
Fragment contribution models for predicting skin permeability using HuskinDB
Authors: Waters Laura J. , Cooke David J. , Quah Xin Ling 
Published: November 2023

AbstractMathematical models to predict skin permeation tend to be based on animal derived experimental data as well as knowing physicochemical properties of the compound under investigation, such as molecular volume, polarity and lipophilicity. This paper presents a strikingly contrasting model to predict permeability, formed entirely from simple chemical fragment (functional group) data and a recently released, freely accessible human (i.e. non-animal) skin permeation database, known as the ‘Human Skin Database – HuskinDB’. Data from within the database allowed development of several fragment-based models, each including a calculable effect for all of the most commonly encountered functional groups present in compounds within the database. The developed models can be applied to predict human skin permeability (logKp) for any compound containing one or more of the functional groups analysed from the dataset with no need to know any other physicochemical properties, solely the type and number of each functional group within the chemical structure itself. This approach simplifies mathematical prediction of permeability for compounds with similar properties to those used in this study.
Superiority of systemic bleomycin to intradermal HOCl for the study of interstitial lung disease
Authors: Morozan Arina , Joy Sydney , Fujii Utako , Fraser Richard , Watters Kevin , Martin James G. , Colmegna Inés 
Published: November 2023

AbstractSystemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, immune dysregulation, and multi-organ fibrosis. Interstitial lung disease (ILD) is a complication of SSc and a leading cause of SSc-death. The administration of hypochlorous acid (HOCl) intradermally in the mouse (HOCl-SSc) purportedly shows several features typical of SSc. We studied the model by injecting BALB/c mice daily intradermally with HOCl for 6-weeks, an exposure reported to induce lung fibrosis. On day 42, the skinfold thickness and the dermal thickness were two and three times larger respectively in the HOCl group compared to controls. HOCl treatment did not result in histological features of pulmonary fibrosis nor significant changes in lung compliance. Automated image analysis of HOCl mice lungs stained with picrosirius red did not show increased collagen deposition. HOCl injections did not increase pulmonary mRNA expression of pro-fibrotic genes nor induced the production of serum advanced oxidation protein products and anti-topoisomerase 1 antibodies. Immune cells in bronchoalveolar lavage fluid (BALF) and whole lung digests were not increased in HOCl-treated animals. Since lung fibrosis is proposed to be triggered by oxidative stress, we injected HOCl to Nrf2−/− mice, a mouse deficient in many antioxidant proteins. Lung compliance, histology, and BALF leukocyte numbers were comparable between Nrf2−/− mice and wild-type controls. We conclude that the HOCl-SSc model does not manifest SSc-lung disease.
Phenogrouping and risk stratification of patients undergoing cardiac resynchronization therapy upgrade using topological data analysis
Authors: Schwertner Walter Richard , Tokodi Márton , Veres Boglárka , Behon Anett , Merkel Eperke Dóra , Masszi Richárd , Kuthi Luca , Szijártó Ádám , Kovács Attila , Osztheimer István , Zima Endre , Gellér László , Vámos Máté , Sághy László , Merkely Béla , Kosztin Annamária , Becker Dávid 
Published: November 2023

AbstractChoosing the optimal device during cardiac resynchronization therapy (CRT) upgrade can be challenging. Therefore, we sought to provide a solution for identifying patients in whom upgrading to a CRT-defibrillator (CRT-D) is associated with better long-term survival than upgrading to a CRT-pacemaker (CRT-P). To this end, we first applied topological data analysis to create a patient similarity network using 16 clinical features of 326 patients without prior ventricular arrhythmias who underwent CRT upgrade. Then, in the generated circular network, we delineated three phenogroups exhibiting significant differences in clinical characteristics and risk of all-cause mortality. Importantly, only in the high-risk phenogroup was upgrading to a CRT-D associated with better survival than upgrading to a CRT-P (hazard ratio: 0.454 (0.228–0.907), p = 0.025). Finally, we assigned each patient to one of the three phenogroups based on their location in the network and used this labeled data to train multi-class classifiers to enable the risk stratification of new patients. During internal validation, an ensemble of 5 multi-layer perceptrons exhibited the best performance with a balanced accuracy of 0.898 (0.854–0.942) and a micro-averaged area under the receiver operating characteristic curve of 0.983 (0.980–0.986). To allow further validation, we made the proposed model publicly available (https://github.com/tokmarton/crt-upgrade-risk-stratification).
The convenient method and application for monitoring the health of traffic sign poles based on mobile phone
Authors: Xie Xiao , Chen Yumin , Li Changchun , Guo Junwei , Sarajpoor Saeed 
Published: November 2023

AbstractTraffic sign poles are crucial components of the highway system, and their maintenance mainly relies on the subjective judgment of staff, which is low-efficiency and will lead to mistaken inspections. This paper proposes a convenient and effective method to monitor the health of sign poles by using a mobile phone. It is unknown whether a mobile phone can be used as a conventional acceleration sensor. Therefore, the performance of the mobile phone was initially tested to ensure its suitability for acquiring the acceleration data of the traffic sign pole. The results show that the acceleration sensor of mobile phones is high-performance and can be used as a traditional acceleration sensor under the similar sampling frequency. The mobile phone can measure the 1st, 2nd and 5th natural frequencies of the traffic sign pole. Although the 1st and 5th natural frequencies have a large error with simulation, the 2nd natural frequency is accurate and stable. The looseness of the base connection greatly impacts on the 2nd natural frequency, which can be used as a measure of the loose base connection. The 2nd natural frequency was measured for 21 times and found to conform to a normal distribution. The relationship between the 2nd natural frequency and base connection loosening was investigated, which fitted to the equation. The fitting result is good and can be used to predict the degree of sign pole base connection loosening. Therefore, the mobile phone based convenient health monitoring method for traffic sign poles is feasible.
Sensitivity analysis of counterweight double-row pile deformation to weak stratum parameters
Authors: Wang Qiongyi , Niu Yungang , Ma Fenghai , Lu Shasha 
Published: November 2023

AbstractIn order to investigate the sensitivity of weak soil parameters on the deformation of balanced double-row piles, a case study was conducted in a deep foundation pit project in Shenzhen City. A variety of analysis methods, including numerical simulation, field measurements, orthogonal experiments, and theoretical analysis, were employed to analyze the impact of three weak soil parameters on the deformation of balanced double-row piles. The research results showed that the deformation of the front and back rows of piles exhibited overturning deformation, gradually decreasing with depth and reaching the maximum at the pile top due to the constraint effect of the balance platform. The numerical simulation results of horizontal displacements for the front and rear piles were in good agreement with the field measurements, confirming the accuracy and reasonableness of the numerical analysis model and parameter selection. Through a series of orthogonal numerical simulation experiments, it was determined that the cohesive strength (C) of soft layers, such as rockfill and silt, is a key factor, the internal friction angle (φ) is an important influencing factor, and the elastic modulus (E) is a general influencing factor. Theoretical analysis was employed to establish the relationship curve between each parameter and the maximum pile deformation, as well as the sensitivity factors, further verifying the impact of these weak soil parameters. The research findings presented in this paper can provide valuable guidance for geotechnical engineers when selecting geological parameters for similar deep excavation projects.
Efficacy of combined tumor irradiation and KCa3.1-targeting with TRAM-34 in a syngeneic glioma mouse model
Authors: Stransky Nicolai , Ganser Katrin , Quintanilla-Martinez Leticia , Gonzalez-Menendez Irene , Naumann Ulrike , Eckert Franziska , Koch Pierre , Huber Stephan M. , Ruth Peter 
Published: November 2023

AbstractThe intermediate-conductance calcium-activated potassium channel KCa3.1 has been proposed to be a new potential target for glioblastoma treatment. This study analyzed the effect of combined irradiation and KCa3.1-targeting with TRAM-34 in the syngeneic, immune-competent orthotopic SMA-560/VM/Dk glioma mouse model. Whereas neither irradiation nor TRAM-34 treatment alone meaningfully prolonged the survival of the animals, the combination significantly prolonged the survival of the mice. We found an irradiation-induced hyperinvasion of glioma cells into the brain, which was inhibited by concomitant TRAM-34 treatment. Interestingly, TRAM-34 did neither radiosensitize nor impair SMA-560’s intrinsic migratory capacities in vitro. Exploratory findings hint at increased TGF-β1 signaling after irradiation. On top, we found a marginal upregulation of MMP9 mRNA, which was inhibited by TRAM-34. Last, infiltration of CD3+, CD8+ or FoxP3+ T cells was not impacted by either irradiation or KCa3.1 targeting and we found no evidence of adverse events of the combined treatment. We conclude that concomitant irradiation and TRAM-34 treatment is efficacious in this preclinical glioma model.
Cumulative effect of impaired fasting glucose on the risk of dementia in middle-aged and elderly people: a nationwide cohort study
Authors: Yu Jin , Lee Kyu-Na , Kim Hun-Sung , Han Kyungdo , Lee Seung-Hwan 
Published: November 2023

AbstractThe relationship between prediabetes and dementia remains controversial. We aimed to examine the association between cumulative exposure to impaired fasting glucose (IFG) and the risk of dementia in the general population. 1,463,066 middle-aged and elderly subjects who had had health examinations for four consecutive years were identified from a Korean nationwide population-based cohort database. IFG was defined as fasting blood glucose 100–125 mg/dL, and the risk of dementia—according to the number of IFG exposure (range 0–4)—was analyzed using the multivariable Cox proportional-hazards model. During the median 6.4 years of follow-up, 7614 cases of all-cause dementia, 5603 cases of Alzheimer’s disease, and 1257 cases of vascular dementia occurred. There was a significant trend towards a higher risk of all-cause dementia (P for trend = 0.014) and Alzheimer’s disease ( Pfor trend = 0.005) according to the cumulative exposure to IFG, but with a modest (approximately 7–14%) increase in the hazards. A significant stepwise increase in the risk of all-cause dementia and Alzheimer’s disease was seen in non-obese subjects, whereas no significant association was observed in obese subjects. This study supports the association between prediabetes and incident dementia and emphasizes that even mild hyperglycemia should not be overlooked.
Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth
Authors: Govindarajan Barani , Sbrissa Diego , Pressprich Mark , Kim Seongho , Rishi Arun K. , Vaishampayan Ulka , Cher Michael L. , Chinni Sreenivasa R. 
Published: November 2023

AbstractThe chemokine receptor, CXCR4 signaling regulates cell growth, invasion, and metastasis to the bone-marrow niche in prostate cancer (PCa). Previously, we established that CXCR4 interacts with phosphatidylinositol 4-kinase IIIα (PI4KIIIα encoded by PI4KA) through its adaptor proteins and PI4KA overexpressed in the PCa metastasis. To further characterize how the CXCR4–PI4KIIIα axis promotes PCa metastasis, here we identify CXCR4 binds to PI4KIIIα adaptor proteins TTC7 and this interaction induce plasma membrane PI4P production in prostate cancer cells. Inhibiting PI4KIIIα or TTC7 reduces plasma membrane PI4P production, cellular invasion, and bone tumor growth. Using metastatic biopsy sequencing, we found PI4KA expression in tumors correlated with overall survival and contributes to immunosuppressive bone tumor microenvironment through preferentially enriching non-activated and immunosuppressive macrophage populations. Altogether we have characterized the chemokine signaling axis through CXCR4–PI4KIIIα interaction contributing to the growth of prostate cancer bone metastasis.