bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytoplasmic vacuolation, intracytoplasmic lumina, and DPAS staining in ductal carcinoma of the breast
Authors: Nijhawan Raje , Rajwanshi Arvind , Gautam Upasana , Gupta Subhash K. 
Published: May 2003

AbstractA retrospective study was carried out on 30 cases of histologically proven invasive ductal carcinoma of the breast with a prior fine‐needle aspiration (FNA) cytology. On evaluating the May‐Grünwald‐Giemsa (MGG) FNA smears, cytoplasmic vacuolation was observed in 70% cases. Positivity with periodic acid Schiff‐positive, diastase‐resistant (DPAS) staining was observed in 90% of cases. The χ2 value on a McNemar test was 4.16. Thus, DPAS staining was significantly superior to MGG staining for picking up cytoplasmic vacuoles (P < 0.05). In 56.67% cases, DPAS staining showed an improvement in score as compared to MGG smears. This was highly significant (P < 0.001) on Wilcoxon matched‐pairs signed‐ranks test. Applying the strict criteria of thick‐walled cytoplasmic vacuoles with a central darkly stained dot, none of our cases revealed true intracytoplasmic lumina. Larger studies are required to establish a role for DPAS staining in separating borderline, in situ, and invasive breast lesions, and to see if such positvity can be incorporated into the grading systems for breast carcinoma. Diagn. Cytopathol. 2003;28:291–294. © 2003 Wiley‐Liss, Inc.
Melanoma of the soft parts: Diagnosis of metastatic and recurrent tumors by aspiration cytology
Authors: Kumar Neeta , Das Partha M. , Jain Shyama , Sodhani Pushpa , Gupta Sanjay 
Published: May 2003

AbstractThree cases of melanoma of the soft parts diagnosed by aspiration cytology and immunochemistry are described. Unusual clinicoradiological features, variable cytomorphology, absence of melanin, and lack of awareness due to rarity of the lesion caused diagnostic dilemma. Morphological similarity to alveolar soft part sarcoma, synovial and epithelioid sarcoma, cutaneous melanoma, poorly differentiated carcinoma, and plasmacytoma were noted. Consideration of clinical data such as age, site, and radiology was helpful in narrowing down the diagnosis. A presumptive cytologic diagnosis helped in selecting the antibody panel, which established the definitive diagnosis in all cases. This approach is valuable in preoperative management and obviates the need for an open biopsy in primary, metastatic, or recurrent tumor. Increasing experience in fine‐needle aspiration of this rare entity and correlation with immunochemistry and histopathology are valuable in narrowing down the differential diagnosis, reducing diagnostic errors, and widening its clinicocytological spectrum. Diagn. Cytopathol. 2003;28:295–300. © 2003 Wiley‐Liss, Inc.
Atypical squamous cells of undetermined significance—rule out high‐grade squamous intraepithelial lesion: Cytopathologic characteristics and clinical correlates
Authors: Alli Patricia M. , Ali Syed Z. 
Published: May 2003

AbstractThe significance and clinical management of atypical squamous cells of undetermined significance (ASCUS) on cervical cytologic smears has been an area of much controversy. This study compiled a list of criteria useful in identifying the subset of cases that would be categorized as atypical squamous cells of undetermined significance‐ rule out high‐grade squamous intraepithelial lesion (ASC‐H) in the new Bethesda System terminology, which eventuate in a diagnosis of cervical intraepithelial neoplasia (CIN). The cytopathology files at Johns Hopkins Hospital were searched for ASC‐H cases from the 3‐yr period 1996–1998, which had definitive clinicopathologic follow‐up (colposcopy and cervical biopsies). The smears were reviewed, cytomorphologic features studied, and clinical correlations performed. ASC‐H was diagnosed in 257 of 45,428 gynecologic smears (0.6%), 72 having had clinicopathologic follow‐up. Of these 72 cases, 35 (49%) on follow‐up had a negative/reactive diagnosis (NR), whereas 37 (51%) turned out to be CIN [CIN‐I–18 (49%) and CIN II and III–19 (51%)]. The significant cytomorphologic differences in the ASC‐H category with a CIN follow‐up (compared with an NR follow‐up) were fewer atypical cells, more often discohesive or seen singly, more monomorphic, a higher nuclear‐to‐cytoplasmic (N/C) ratio, greater nuclear hyperchromasia, more coarse, unevenly dispersed chromatin, more prominent nuclear membrane irregularities, lack of nucleoli, chromocenters or nuclear grooves, and lack of an inflammatory background. Careful attention to subtle cytomorphologic characteristics may be helpful for a more definitive subdivision of ASC‐H terminology into a NR and a CIN diagnosis. Diagn. Cytopathol. 2003;28:308–312. © 2003 Wiley‐Liss, Inc.
Clear cell sarcoma (malignant melanoma of soft parts): Fine‐needle aspiration cytology of a highly pigmented tumor
Authors: Salem Shabb Nina , Boulos Fouad , Tawil Ayman , Hussein Maher , Hourani Mukbil 
Published: May 2003

AbstractDiagnosis of clear cell sarcoma by fine‐needle aspiration is difficult, as melanin is usually absent. Here we describe a case of a primary clear cell carcinoma with abundant melanin, making diagnosis definitive. Diagn. Cytopathol. 2003;28:313–315. © 2003 Wiley‐Liss, Inc.
Diagnostic pitfalls of peritoneal washing cytology and the role of cell blocks in their diagnosis
Authors: Selvaggi Suzanne M. 
Published: May 2003

AbstractMesothelial cell hyperplasia, collagen balls, endometriosis, and endosalpingiosis are diagnostic pitfalls on peritoneal washing cytology in women who present with gynecologic lesions. Over an 8‐month period, the peritoneal washings from 10 patients undergoing gynecologic surgery for presumed malignancy showed unusual cytologic findings, several of which posed diagnostic difficulties. The washings from four patients with ovarian carcinomas were cellular and contained clusters and strips of cells with cytologic atypia mimicking malignancy. Confirmation of their benign mesothelial origin was confirmed on immunohistochemistry utilizing cell block preparations. In two cases of endometrial endometrioid carcinoma, the washings contained several clusters of cells surrounding and/or admixed with a globular substance. Due to their similarity to endometrial cells, immunohistochemistry was performed on cell block preparations. The cells were positive for cytokeratin and negative for carcinoembryonic antigen and B72.3, confirming their mesothelial origin. In one case, clinically presumed to be a malignant mass, the washings contained tight clusters of cells with mild cytologic atypia admixed with hemosiderin‐laden macrophages. In conjunction with the cell block findings, a diagnosis of endometriosis was made. Extensive endometriosis was found on the surgically resected specimen. In two cases, strips of ciliated epithelial cells resembling tubal epithelium were present on the cytologic and cell block preparations, consistent with endosalpingiosis. The peritoneal washings in one case contained several clusters and balls of atypical cells surrounding microcalcifications on cell block preparation. Since calcification within groups of cells in peritoneal washings always raised the possibility of malignancy, a serous carcinoma of the ovary, particularly of borderline malignancy, would have to be excluded. Fortunately, the resected specimen was free of tumor and showed calcified endosalpingiosis on the ovarian surface. Preparation of cell blocks from peritoneal washings is of value in the work‐up and management of patients who present with cytologic mimickers of malignancy on fluid cytology. Diagn. Cytopathol. 2003;28:335–341. © 2003 Wiley‐Liss, Inc.
Evaluation of fluorescence in situ hybridization as an ancillary tool to urine cytology in diagnosing urothelial carcinoma
Authors: Veeramachaneni Ravindra , Nordberg Mary L. , Shi Runhua , Herrera Guillermo A. , Turbat‐Herrera Elba A. 
Published: May 2003

AbstractOur purpose was to evaluate the feasibility of performing fluorescence in situ hybridization (FISH) on routine urine samples and to compare the relative sensitivities of urine cytology and FISH for detecting urothelial carcinoma. Light microscopy (LM) using cytologic evaluation and FISH were used to study 121 consecutive urine samples. A mixture of fluorescent probes to chromosomes 3, 7, 17, and the 9p21 locus were used for detection of numerical chromosomal abnormalities (UroVysion, Vysis/Abbott). Biopsy specimens from patients in the study were reviewed if available. FISH analysis was performed without knowledge of cytology or biopsy findings. The urine cytology of 121 samples was interpreted as 59 negative, 41 reactive, 16 atypical, 2 suspicious and 3 insufficient cells for diagnosis. 85 samples were successfully analyzed by FISH. Thirty‐one of these showed chromosomal abnormalities and these samples were initially regarded on the original cytology reading as follows: 10 negative, 10 reactive, 9 atypical, and 2 suspicious. FISH demonstrated chromosomal abnormalities in a significant number of cases (67%) that were initially diagnosed as normal or reactive by LM. Twenty‐five patients were identified who had biopsy‐proven TCC and successful FISH. Thirteen of the 25 patients (52%) were abnormal by FISH (cytology: 2 suspicious, 6 atypical, 4 reactive, 1 negative). One patient was atypical by cytology with normal FISH results but had TCC on biopsy. Hyperdiploidy for chromosomes 3 (77%) and 7 (67%) were seen consistently. Multiple chromosomal abnormalities were seen in 67% of these cases. We conclude that FISH has a greater sensitivity in detecting urothelial carcinoma when coupled with urine cytology. It is not entirely clear at this time whether a positive FISH may indicate frank neoplastic urothelial transformation or merely be an indicator of unstable urothelium capable of or primed for malignant transformation thus detecting patients at significant risk. The use of FISH in conjunction with urine cytology can potentially reduce urothelial carcinoma morbidity and mortality by diagnosing these tumors earlier. Diagn. Cytopathol. 2003;28:301–307. © 2003 Wiley‐Liss, Inc.
Glomus tumor of the stomach: Cytologic diagnosis by endoscopic ultrasound‐guided fine‐needle aspiration
Authors: Debol Steven M. , Stanley Michael W. , Mallery Shawn , Sawinski Elizabeth , Bardales Ricardo H. 
Published: May 2003

AbstractThe glomus tumor is usually a benign solitary neoplasm that arises from modified smooth muscle cells of the glomus body, a type of neuromyoarterial receptor that plays a role in the regulation of arterial blood flow. We report a case of gastric glomus tumor diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration. Smears exhibited groups of cohesive, uniform, small, round to polygonal cells with scant cytoplasm, indistinct cell borders, and round, hyperchromatic nuclei with homogeneous chromatin. The cell block contained fragments of cells with similar morphologic features and immunohistochemical staining exhibited positivity for smooth muscle actin and vimentin. The diagnosis was confirmed by the surgically resected specimen. Ultrastructural examination revealed prominent pinocytotic vesicles lining the plasmalemma. In this report, we discuss the differential diagnosis of gastric glomus tumor and compare the cytologic features of this case with two others reported in the literature. Diagn. Cytopathol. 2003;28:316–321. © 2003 Wiley‐Liss, Inc.
Fine‐needle aspiration of rheumatoid nodule: A case report with review of diagnostic features and difficulties
Authors: Kalugina Yelena , Petruzzelli Guy J. , Wojcik Eva M. 
Published: May 2003

AbstractPatients with rheumatoid arthritis may develop extra‐articular subcutaneous nodules as part of the systemic disease or as initial manifestation. These lesions may represent significant diagnostic dilemmas in patients with clinical suspicion of malignancy. In this setting, fine‐needle aspiration (FNA) of the nodules may be the simplest and most appropriate diagnostic approach. In the literature, however, there are only sporadic reports describing FNA cytology of a rheumatoid nodule. In this report, we present a case of a 67‐year‐old male with a history of rheumatoid arthritis and squamous‐cell carcinoma of the larynx who developed a subcutaneous neck nodule in the immediate proximity of the surgical scar. Clinically, because of the history of squamous‐cell carcinoma and location of the lesion, the nodule was suspected to be metastatic cancer, but was proven by FNA biopsy to represent rheumatoid disease. Cytological criteria of rheumatoid nodule and diagnostic difficulties are discussed. Diagn. Cytopathol. 2003;28:322–324. © 2003 Wiley‐Liss, Inc.
Amyloid tumor: A clinical and cytomorphologic study
Authors: Sahoo Sunati , Reeves Ward , DeMay Richard M. 
Published: May 2003

AbstractWe describe the cytologic findings and clinical presentation of three unusual cases of amyloid tumor. Two of our patients had low‐grade lymphoid malignancies and the third insulin‐dependent diabetes mellitus. In no cases was amyloid suspected as the cause of mass lesion. Two of our cases presented with superficial soft tissue mass and the third with right breast masses and bilateral axillary lymph node enlargement. Air‐dried slides from all aspirated cases were stained with Diff‐Quik for specimen adequacy evaluation. The remaining fixed slides were stained with Papanicolaou stain. Amyloid appeared as dark‐blue to purple clumps of acellular material on Diff‐Quik stain, accompanied with chronic inflammatory cell infiltrates and multinucleated giant cells, simulating granulomatous inflammation. Papanicolaou stain demonstrated cyanophilic to orangophilic acellular material. Amyloid was suspected and subsequently confirmed by Congo red stain. Diagn. Cytopathol. 2003;28:325–328. © 2003 Wiley‐Liss, Inc.
History of anorexia nervosa in bulimic patients: Its influence on body composition
Authors: Vaz Francisco J. , Guisado Juan A. , Peñas‐Lledó Eva M. 
Published: May 2003

AbstractObjectiveTo analyze the body composition of a group of patients fulfilling DSM‐IV criteria for bulimia nervosa (BN), comparing the patients who had a history of DSM‐IV anorexia nervosa (AN) with those without such a history to determine (1) whether both groups differed in terms of body composition and (2) whether the differences between groups could be the consequence of the past condition.MethodsThe sample consisted of 104 patients, 43 with prior AN (BN‐AN group) and 61 without a history of AN (BN‐nonAN). The patients were assessed using anthropometric and bioelectrical methods: height and weight, body circumferences, abdominal diameter, skinfold thickness, and body impedance analysis. In a later phase and to test the influence of current low weight on the results, two experimental groups were created: the first group was composed of the patients from the BN‐AN group who had a normal body mass index (BMI range in this group, 20.1–23.4kg/m2; n = 23); the second group consisted of 23 patients from the BN‐nonAN group in the same BMI range. In both phases unpaired sample t tests were performed for statistical analysis. ResultsMore than 40% of the bulimic patients with a history of AN had a BMI less than 20. They had a lower percentage of body fat, lower muscle mass, and higher percentage of extracellular water. Nevertheless, most of these differences disappeared in the second phase of the analysis, when only the patients within a normal weight range were compared. DiscussionAccording to these results, a significant number of bulimic patients with a history of AN tend to retain some clinical traits of the past condition and could be viewed as remaining in a “subclinical anorexic status”: they are thinner and seem to have less difficulties in maintaining low weight than patients without a history of AN. Nevertheless, in patients who have reached a normal weight after AN, all these differences disappear. This fact raises some important questions related to the boundaries between AN and BN, the shifting from one to another, or when AN patients really recover. © 2003 by Wiley Periodicals, Inc. Int J Eat Disord 34: 148–155, 2003.
Resting energy expenditure and plasma leptin levels in adolescent girls with anorexia nervosa
Authors: Satoh Yayoi , Shimizu Toshiaki , Lee Tsubasa , Nishizawa Kyoko , Iijima Megumi , Yamashiro Yuichiro 
Published: May 2003

AbstractObjectiveOur aim was to examine the relationship between resting energy expenditure (REE) and circulating leptin levels during long‐term refeeding in adolescent girls with anorexia nervosa (AN).MethodWe measured REE, the plasma leptin level, the free T3 level, body surface area (BSA), and dietary energy intake in AN adolescents before and 8 weeks after refeeding therapy.ResultsAll parameters in AN subjects before the refeeding therapy were significantly lower than those in AN subjects after the therapy and in the controls. There were no significant differences in REE and BSA between posttherapy AN subjects and controls, but plasma leptin levels in the posttherapy AN subjects were still significantly lower than those in the controls. Significant correlations between REE and BSA were detected in the AN subjects both before and after the refeeding therapy, but REE did not correlate significantly with plasma leptin level in either of the AN groups.DiscussionOur results suggest that the REE in AN subjects after long‐term refeeding therapy is not associated with the changes in plasma leptin levels but with BSA. © 2003 by Wiley Periodicals, Inc. Int J Eat Disord 34: 156–161, 2003.
Gender differences in implicit weight identity
Authors: Grover Vishal P. , Keel Pamela K. , Mitchell Jason P. 
Published: May 2003

AbstractObjectiveThis study examined gender differences in explicit and implicit attitudes toward overweight and explicit and implicit weight identity.MethodNormal weight women (n=22) and men (n=20) and overweight women (n=20) and men (n=21) completed the Implicit Association Test and portions of the Eating Disorders Questionnaire.ResultsAlthough explicit and implicit anti‐fat attitudes were ubiquitous, gender differences emerged for weight identity. Both men and women provided accurate explicit appraisals of their weight status. However, men implicitly identified themselves as light regardless of actual weight status. Women's implicit weight identity was associated with their actual weight status, explicit weight appraisal, and implicit self‐esteem.DiscussionThese findings may provide additional insight into why men are underrepresented among those seeking weight loss and why women are at increased risk for developing eating disorders. © 2003 by Wiley Periodicals, Inc. Int J Eat Disord 34: 125–135, 2003.
Body image and eating disturbance among south Asian‐American women: The role of racial teasing
Authors: Sahi Iyer Dana , Haslam Nick 
Published: May 2003

AbstractObjectiveAcculturation and loss of ethnic identification have been proposed as risk factors for eating and body image disturbance among women of color. This study investigated whether being teased about racial or ethnic features might also play a role in these disturbances in minority women.MethodsOne hundred twenty‐two college women of South Asian descent completed questionnaire measures of disturbed eating behavior, body image dissatisfaction, distress, self‐esteem, acculturation, ethnic identification, and racial teasing.ResultsHistory of hurtful racial teasing, but not acculturation or ethnic disidentification, was associated with disturbed eating and body image, even after controlling for distress, self‐esteem, and body mass.ConclusionThe psychological impact of racial teasing may be a potent but neglected source of eating and body image disturbance among minority women. © 2003 by Wiley Periodicals, Inc. Int J Eat Disord 34: 142–147, 2003.
A sliding mode controller for manipulator driven by artificial muscle actuator
Authors: Cai Dawei , Dai Ying 
Published: May 2003

AbstractAn artificial muscle actuator manipulator is a manipulator driven by an artificial muscle actuator. The artificial muscle actuator has less weight and more output than pneumatic or hydraulic cylinders. It also has good flexibility and a high level of safety. Therefore, wide ranges of applications in industry and medical assistance are expected. If the nonlinear dynamics of the actuator are neglected, it is considered difficult to achieve accurate and fast trajectory tracking. For trajectory control of the manipulator, a new control approach with excellent robustness involving a sliding mode control technique is proposed, in which the instability of the characteristics of artificial muscle and the unknown portions of the manipulator are taken into account. Further, by an analysis based on Lyapunov stability theory, the stability and tracking error convergence of this control method are analyzed. The stability of the tracking error closed loop system consisting of the proposed controller is proved. Also, in the case with external disturbance, the proposed control method is modified to provide a sliding mode control method for the case with external disturbance. Finally, the effectiveness of the method is demonstrated by the results of simulation experiments. © 2003 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 86(11): 57–64, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjc.10046
A bipolar logistic chaos neuron and its hardware implementation
Authors: Matsuzaki Tetsuya , Nakagawa Masahiro 
Published: May 2003

AbstractA novel bipolar logistic chaos neuron model (bLCN) is proposed as an example of nonmonotonic neuron models for hardware implementation. The activation function is approximated in quadratic form, which is reminiscent of logistic mapping, instead of the sinusoidal form previously investigated. In this report, we shall analyze the bifurcation characteristics and the corresponding invariant measures of the monotonic chaos neuron model (MCN), the periodic chaos neuron model (PCN) proposed earlier, and the bLCN. We shall confirm that the PCN and bLCN have symmetric response, in contrast to the MCN. Furthermore, we shall present an electronic circuit model of the presently proposed bLCN, and compare it with the numerical model. © 2003 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 86(11): 46–56, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjc.10063
A software reliability assessment method based on neural networks for distributed development environment
Authors: Tamura Yoshinobu , Yamada Shigeru , Kimura Mitsuhiro 
Published: May 2003

AbstractThe software development environment has been changing into a new development paradigm in CSSs (client/server systems) by the use of network computing technologies. Therefore, it is important to assess the reliability of software system in a distributed development environment because of increasing demands on quality and productivity in social systems. However, it is difficult to assess software reliability in recent years because the complexity of software systems has been increasing as a result of distributed system development.In this paper, we propose a software reliability assessment method considering the interaction among software components in the system‐testing phase of a distributed development environment. © 2003 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 86(11): 13–20, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjc.10092