bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brolucizumab for Wet Aged-Related Macular Degeneration Patients : too Good to be True
Authors: Purbonegoro Tania , Prayogo M. Eko , Agni A. Nurini , W. Tri Wahyu , Supanji  , W. Firman S. , Sasongko M.B 
Published: February 2024

Introduction & ObjectivesBrolucizumab is the newest anti-vascular endothelial growth factor (anti-VEGF). It showed superioranatomic outcomes and noninferiority best corrected visual acuity (BCVA) results for Wet Aged-Related Macular Degeneration (Wet-AMD) compared to other anti-VEGF. In Yogyakarta, it's beenonly used in a few patients and we want to report the effectiveness and safety of brolucizumab inWetAMD
MethodsIn this retrospective study, all wetAMD patients who underwent Brolucizuab intravitreal injectionsbetween December 2021 and January 2023 at Dr YAP Eye Hospital were studied. Patient’sdemographic data, before and after intravitreal brolucizumab injections (central macular thickness,intraocular pressure, and BCVA) were assessed.
ResultsThis study included 6 eyes of 6 patients (3 women) with a mean age of 69.5 years old. The meanfollow-up period was 27 ± 10.1 weeks after the first injection of brolucizumab. Three patients werenaïve wetAMD patients, three anti-VEGF experienced wetAMD patients. The mean BCVA at baseline(before brolucizumab injection) was 0.12 decimal (6/48) and 0.29 decimal (6/20) at the last followup.Five out of six patients' visual acuity were improved. In four out of six patient central macularthickness were reduced (mean difference 29,2 um). None of the patient's intraocular pressureincreased over 21 mmHg. None of the patients reported any signs of inflammation, vasculitis, ocularor systemic adverse effects.
ConclusionThis limited data demonstrated that brolucizumab was relatively safe and effective in stabilizingBCVA for both WetAMD patients who had previous treatment with other anti-VEGF agents andnaive. Larger sample sizes studies & future multicenter collaborative are warranted
CORRELATION BETWEEN PLATELET PARAMETERS AND THE SEVERITY OF PRIMARY OPEN ANGLE GLAUCOMA
Authors: Gunanegara Abdi Sastra , Yuliawati Putu , Kusumadjaja I Made Agus 
Published: February 2024

Introduction & ObjectivesPrimary open angle glaucoma (POAG) is a chronic optic neuropathy characterized by slowlyprogressive visual function loss. Platelet activation as well as its interaction with vascularendothelium and plasma components, play an important role in the vascular pathophysiology ofPOAG. Platelet aggregation in glaucoma tends to increase. This change has negative impact on smallvessel circulation in the eye, such as branches of short ciliary arteries supplying the optic nerve. Inthis study, we will assess the correlation between platelet parameters and the severity of POAG.
MethodsThis study is an analytical observational study. Data were obtained retrospectively and prospectivelywith a cross sectional study approach conducted at Sanglah Hospital, Denpasar. The study samplewas 62 eyes selected consecutively. Data was analyzed using SPSS. Descriptive data presentednumerically or categorically, bivariate analysis using Pearson and Spearman correlation tests andmultivariate analysis using logistic regression.
ResultsResults showed that the mean age of the research subjects was 66.71 ± 9.795 years, with themajority was male (70.6%). Bivariate analysis, showed no significant correlation between plateletparameters (PLT, PDW, MPV) and the severity of POAG. Multivariate analysis found that age ? 68years, 9,850 times more likely to develop moderate to severe glaucoma, compared to patients < 68years old (OR 9,850, 95% CI, p = 0.009).
ConclusionPlatelet parameters showed no significant correlation with the severity of POAG, meanwhile olderage is more at risk of developing moderate to severe POAG.
Anti-RAGE (Receptor Advanced Glycation End products) Antibody Improves Diabetic Retinopathy in Rats via Hypoglycemic and Anti-inflammatory Mechanism
Authors: Indiarsih Tiara Bunga , Amin Ramzi , Ansyori A.K. 
Published: February 2024

Background: Receptor advanced glycation end products (RAGE) activation plays an essential role in diabetic retinopathy (DR) progression. This study was aimed to explore the role of anti-RAGE antibodies (RAGE antagonists) in inhibiting DR progression through their hypoglycemic and anti- inflammatory mechanism in diabetic retinopathy induced rats.
Methods: A total of 30 male Wistar rats were randomly divided into five group. The group was consisted of normal control group, DR group without treatment, DR group with anti-RAGE 1 g/kg BW, 10 g/kg BW, and 100 g/kg BW. To assess the diabetic retinopathy, fundus photographs were taken every week using a camera with 16x magnification placed in front of the rat's eyes. Blood glucose was checked by the glucose oxidase-peroxidase method. Retinal TNF-? levels and VEGF were examined using an enzyme-linked immunosorbent assay (ELISA) kit.
Results: The finding of this study showed that anti-RAGE treatment at dose of 10 and 100 g/kg BW, HbA1c levels were significantly higher (p< 0.05) compared to the normal control group but significantly lower (p< 0.05) than in the diabetes group. The mean blood vessel diameter in the DR+anti-RAGE 10 and 100 g/kg BW groups was significantly lower than in the diabetic retinopathy group (p< 0.05). The administration of anti-RAGE 10 and 100 g/kg BW showed the ability to significantly reduce VEGF levels compared to the DR group (p< 0.05).
Conclusions: This study revealed at doses of 10 and 100 g/kg BW, anti-RAGE antibodies improved diabetic retinopathy in Wistar rats through hypoglycemic effects and anti-inflammatory mechanisms.
The main revisions proposed in Amendment No. 3 to CP 32.13330.2018 «Sewerage. External networks and structures»
Authors: Данилович Д.А. , Фрог Д.Б. , Верещагина Л.М. 
Published: February 2024

Описаны основные новации, внесенные в СП 32.13330.2018 «Канализация. Наружные сети и сооружения» Изменением № 3, разработанным НИИ строительной физики Российской академии архитектуры и строительных наук в 2023 г. Введены понятия: основные технические решения и требования к их разработке, производственно-ливневая система канализации на промышленных предприятиях и требования к ее проектированию. Уточнены требования к применяемым системам водоотведения. Установлены уточненные и расширенные требования к применению одно- и двухступенчатого процеживания сточных вод, ацидофикации осадка первичных отстойников, методам биологической очистки сточных вод, УФ-обеззараживания очищенных сточных вод, стабилизации и обеззараживания осадков сточных вод, термосушки и термоутилизации осадков. Упрощены требования к захоронению осадка сточных вод.
The main revisions CP 32.13330.2018 «Sewerage. External networks and structures» proposed in Amendment No. 3, developed by the Research Institute of Building Physics of the Russian Academy of Architecture and Construction Sciences in 2023 are described. The following concepts were introduced: basic technical solutions and requirements for their development, industrial storm sewer systems at industrial enterprises and requirements for their design. The requirements to the existing wastewater disposal systems have been clarified. The revised and extended requirements have been established for the use of one- and two-stage wastewater screening, acidification of primary sludge, biological wastewater treatment methods, UV disinfection of effluents, stabilization and disinfection of wastewater sludge, thermal drying and thermal utilization of sludge. Requirements to the disposal of wastewater sludge have been simplified.
Expediente
Authors: Schwanke Cibele 
Published: February 2024

Conselho Editorial Editora-chefe: Cibele Schwanke (IFRS) - Campus Porto Alegre Maria Cristina Caminha de Castilhos França (IFRS) - Campus Porto Alegre Evandro Manara Miletto (IFRS) - Campus Porto Alegre Filipe Xerxeneski da Silveira (IFRS) - Campus Porto Alegre Gabriela Fernanda Cé Luft (IFRS) - Campus Porto Alegre Lizandra Brasil Estabel (IFRS) - Campus Porto Alegre Magali Lippert da Silva (IFRS) - Campus Porto Alegre Telmo Francisco Manfron Ojeda (IFRS) - Campus Porto Alegre Conselho CientíficoAndré Frazão Teixeira (Universidade de Trás-os-Montes e Alto Douro, Portugal)Andréa Poletto Sonza (Instituto Federal do Rio Grande do Sul, Brasil)Carlos Roberto dos Anjos Candeiro (Universidade Federal de Goiás, Brasil)Clarice Monteiro Escott (Instituto Federal do Rio Grande do Sul, Brasil)Diogo Onofre de Souza (Universidade Federal do Rio Grande do Sul, Brasil)Fernanda Valli Nummer (Universidade Federal do Pará, Brasil)Franclin Costa do Nascimento (Instituto Federal de Brasília, Brasil)Júlio Xandro Heck (Instituto Federal do Rio Grande do Sul, Brasil)Leandro Lesqueves Costalonga (Universidade Federal do Espírito Santo, Brasil)Leonardo Xavier da Silva (Universidade Federal do Rio Grande do Sul, Brasil)Luciana Calabró Berti (Universidade Federal do Rio Grande do Sul, Brasil)Maria do Rocio Fontoura Teixeira (Universidade Federal do Rio Grande do Sul, Brasil)Maria Helena Paiva Henriques (Universidade de Coimbra, Portugal)Valdir José Morigi (Universidade Federal do Rio Grande do Sul, Brasil) Editores Elisabeth Ibi Frimm Krieger Magali da Silva Rodrigues Editores de seçãoElisabeth Ibi Frimm Krieger (Parque Açorianos)Luiz Felipe Velho (Parque Marinha do Brasil)Magali da Silva Rodrigues (Parque Moinhos de Vento)Simone Caterina Kapusta (Parque Farroupilha)Editoração eletrônica Cibele Schwanke Capa, diagramação e layoutMaicon Eric Nunes de Godoy ComunicaçãoSamantha Prestes Monteiro – Bolsista Proppi (IFRS) Colaboradores David Matos Milhomens – Bibliotecário (IFRS)Samantha Prestes Monteiro – Bolsista Proppi (IFRS) FomentoPrograma de Apoio à Edição de Periódicos Científicos do IFRS (IFRS/Proppi) Avaliadores ad hoc Aline HentzCarlos Cezar da SilvaClaudia Maria Tomás MeloCristina Claumann FreygangDarlene Ana de Paula VieiraDavis Pereira de PaulaErika Guedes MagalhãesFabiano Perin GasparinGean Delise Leal Pasquali VargasGradisca de Oliveira Werneck de CapistranoHenri Luiz FuchsIsabel Amaral MartinsJeferson GonçalvesJoão Pedro Marque RibeiroJulian Silveira Diogo de Avila FontouraJuliano Rodrigues GimenezKarin TalliniKatia Helena Lipp NissinenLiane WernerPaula Beatriz Domingos Faria
Identificação e análise dos modelos didáticos de um grupo de professores de Biologia do ensino Médio
Authors: Rodrigues Junior Edmundo , Moraes de Oliveira Marcela , Destéffani Admiral Tiago 
Published: February 2024

Identificar e analisar os modelos didáticos dos docentes pode ser o início para se pensar em estratégias de ensino para melhorar o ensino de ciências. Para atingir o objetivo aplicamos um questionário a 20 professores de biologia do ensino médio. Identificamos os modelos didáticos dos docentes a partir das suas percepções sobre: os objetivos para ensinar, os conteúdos a ensinar, as concepções e os interesses dos alunos, a metodologia e sobre a avaliação. Em todas as dimensões supracitadas percebemos uma tendência dos professores em reconhecer as visões construtivistas do ensino, isto é, assumir crenças didáticas associadas aos modelos espontaneísta e investigativo. No entanto, os professores ainda possuem uma tendência conservadora para avaliar os alunos. Entender o perfil dos docentes pode facilitar a elaboração de projetos de formação continuada mais eficazes e com ênfase na dimensão avaliação
Violência doméstica e intrafamiliar impactos no processo de escolarização
Authors: Ikuma Daniel Massayuki , Leva Larissa Raquel Alves 
Published: February 2024

O objetivo desta pesquisa consiste em desvelar os impactos da violência doméstica e intrafamiliar no desempenho acadêmico de crianças e adolescentes. A investigação científica referencia-se a partir das abordagens quantitativa/qualitativa, utilizando como método a revisão bibliográfica. Foram analisadas pesquisas publicadas na Scientific Eletronic Library Online entre os anos de 2013 e 2021 em língua portuguesa. Os resultados demonstram que a violência se tornou um problema social e de saúde pública que se mantêm de forma naturalizada na cultura brasileira e se fortalece como um dos principais indicadores do baixo rendimento escolar, comportamentos agressivos, dificuldade de relacionamento com pessoas e o uso abusivo de drogas. Portanto, conclui-se nesta investigação, a importância da continuidade de outros estudos para a compreensão deste fenômeno complexo relacionado à violência doméstica e intrafamiliar, vivenciado pelas crianças e adolescentes durante o processo de escolarização.
Palavras-chave: Violência doméstica. Interação familiar. Educação.
The Impact of Capital Structure, Investment Growth, and Liquidity on Financial Performance of Automotive Companies and Its Components on The Indonesia Stock Exchange (2018-2022)
Authors: Mandasari Riska 
Published: February 2024

Purpose: This study analyzes the influence of capital, investment, and liquidity structures on the financial performance of automotive companies and their components listed on the Indonesia Stock Exchange (IDX) from 2018 to 2022.
Research methodology: Multiple regression analysis was used and data were obtained from the company's annual financial statements from 2018 to 2022. The findings of this study are expected to provide important insights for financial managers and stakeholders in managing company finances, and serve as a reference for investors and creditors in evaluating the financial performance of a company.
Results: The results show that capital structure has a significantly positive effect on financial performance, while investment and liquidity do not significantly affect financial performance.
Limitation: The study's limitation is that it focuses solely on automotive companies listed on the Indonesia Stock Exchange during the specified timeframe.
Contribution: The study's contribution is that it provides empirical evidence regarding the impact of capital structure, investment growth, and liquidity on financial performance in the Indonesian automotive industry, which can inform future research and practical applications in this context.
Implementation: Capital structure refers to the combination of debt and equity used to finance a company's operations, whereas investment refers to the use of funds or fixed assets to increase the value of the company's products. Liquidity refers to the ability of a company to meet its financial obligations in a timely manner. Multiple linear regression analysis was used in this study, and a sample of 15 companies was selected using purposive sampling.
PELATIHAN MEMBUAT PAVING BLOCK BERBAHAN LIMBAH BOTOL KACA GUNA MENINGKATKAN PEREKONOMIAN MASYARAKAT KELURAHAN MARIANA ILIR, KEC. BANYUASIN I, KAB. BANYUASIN
Authors: Hijrah Agung Sarwandy Muhammad , Dicky Kurniawan Muhammad , Putri Nabila Anisa 
Published: February 2024

Latar belakang pengabdian ini karena permasalahan perekonomian masyarakat Mariana Ilir. Penggunaan sampah botol kaca yang banyak sering kita jumpai dalam kehidupan sehari-hari. Botol kaca banyak digunakan karena tingginya kebutuhan pemakaian harian. Dari data Asosiasi Industri Plastik Indonesia (INAPLAS) dan Badan Pusat Statistik (BPS) menunjukan bahwa sampah plastik di Indonesiaa mencapai 64 juta ton per tahun. Demi mendapatkan lingkungan yang baik dan sehat, maka pengelolaan sampah diperlukan. Pengurangan sampah terdiri dari 3R yaitu mereduksi timbulan (reduce), pemanfaatan kembali (reuse) dan daur ulang (recycle). Dalam rangka program pengurangan sampah 3R ini masyarakat dapat ikut berpartisipasi. Dengan adanya pelatihan pembuatan paving block dari limbah botol kaca, tidak saja membantu menjaga kebersihan lingkungan namun juga dapat meningkatkan roda ekonomi masyarakat Desa.

Kata Kunci: Pelatihan, Pengurangan Sampah, Paving Block
Improving Venous Thromboembolism Prophylaxis Through Service Integration, Policy Enhancement, and Health Informatics
Authors: Abuzied Yacoub , Deeb Ahmad , AlAnizy Layla , Al-Amer Rasmieh , AlSheef Mohammed 
Published: February 2024

ABSTRACT

Introduction
Venous thromboembolism (VTE) prevention and management are susceptible issues that require specific rules to sustain and oversee their functioning, as preventing VTE is a vital patient safety priority. This paper aims to investigate and provide recommendations for VTE assessment and reassessment through policy enhancement and development.

Methods
We reviewed different papers and policies to propose recommendations and theme analysis for policy modifications and enhancements to improve VTE prophylaxis and management.

Results
Recommendations were set to enhance the overall work of VTE prophylaxis, where the current VTE protocols and policies must ensure high levels of patient safety and satisfaction. The recommendations included working through a well-organized multidisciplinary team and staff engagement to support and enhance VTE’s work. Nurses’, pharmacists’, and physical therapists’ involvement in setting up the plan and prevention is the way to share the knowledge and paradigm of experience to standardize the management. Promoting policies regarding VTE prophylaxis assessment and reassessment using electronic modules as a part of the digital health process was proposed. A deep understanding of the underlying issues and the incorporation of generic policy recommendations were set.

Conclusion
This article presents recommendations for stakeholders, social media platforms, and healthcare practitioners to enhance VTE prophylaxis and management.
Improving Patient Safety: Learning from Reported Hospital-Acquired Pressure Ulcers
Authors: Forkuo-Minka Anthony Octo , Kumah Augustine , Asomaning Afua Yeboaa 
Published: February 2024

ABSTRACT

Introduction
A hospital-acquired pressure ulcer (HAPU) is a localized lesion or injury to the underlying tissue (wound) while the patient is on admission. It occurs when standardized nursing care is not correctly followed in the presence of friction and shear, leading to skin or underlying tissue breakdown. Unfortunately, inadequate knowledge of nurses to assess and provide standardized care for pressure ulcers or manage HAPUs results in patient harm. We aim to share lessons from a reported HAPU incident and address the knowledge gap in patient safety risk assessment, identification, and wound management at Nyaho Medical Centre (Accra, Ghana).

Methods
A review of HAPU incidents was conducted using quality improvement tools such as cause-and-effect analyses to identify contributing factors and root causes. Subsequently, plan-do-study-act (PDSA) cycles were used to test interventions to improve pressure ulcer assessments and wound management. A run chart was used to analyze and evaluate the interventions over 12 weeks (Aug–Oct 2021).

Results
Development of policies and a standard operating procedure for pressure ulcers and wounds improved accuracy in identifying pressure ulcer risks and management of wounds. Eighty-three patients were assessed with the pressure ulcer assessment tool. Complete (100%) adherence to the pressure ulcer and wound policy and standard operating procedure (SOP) was achieved, and the number of HAPUs decreased from five to one during the study period.

Conclusion
This study demonstrated that the combined use of quality methods and tools can be suitable for improving processes and outcomes for patients at risk for HAPUs.
CARGA IMEDIATA EM PROTOCOLO ALL ON FOUR DE MANDÍBULA
Authors: Alberto Amanda Pereira Leite , Oliveira Pedro Henrique Moreira de , Salomé Amanda Kelly de Lima , Souza Jonathan William Santos , Silva Ítalo Pereira de Oliveira da , Celestino Jamesson dos Santos , Pinto Flavia Maria Moreira , Costa Paula Regina Domingos , Vilarim Lívia Numeriano de Sá Gomes , Fernandes Rafael de Aguiar , Moura Diogo Henrique Juliano Pinto de 
Published: February 2024

O edentulismo, caracterizado como uma deficiência física com atributos semelhantes a uma condição crônica, demanda abordagens estratégicas para superar as limitações funcionais e psicológicas associadas. Este artigo tem como objetivo explorar a aplicação da carga imediata no protocolo All-on-Four de mandíbula, destacando as vantagens da técnica, suas considerações críticas durante o procedimento cirúrgico e a reconstrução protética. Para tanto, adotou-se uma abordagem baseada em análises retrospectivas de publicações científicas, empregando as bases de dados PubMed e Google Acadêmico como fontes primárias de informação. A estratégia de busca foi cuidadosamente elaborada por meio da combinação de palavras-chave relevantes, visando incluir artigos de revisão de literatura e pesquisas clínicas diretamente relacionadas à pergunta norteadora deste trabalho. A abordagem All-on-Four não só demonstra eficácia clínica, mas também se destaca como uma escolha pragmática, proporcionando resultados positivos de maneira mais eficiente em comparação com protocolos mais extensos. Sua capacidade de superar desafios comuns em procedimentos convencionais contribui para sua crescente aceitação na prática clínica, proporcionando uma solução reabilitadora completa sobre implantes. Essas conclusões reforçam a relevância do protocolo All-on-Four como uma alternativa viável e eficiente na tomada de decisões clínicas, oferecendo benefícios não apenas econômicos e de economia de tempo, mas também resultados estéticos e funcionais satisfatórios para os pacientes.
PERBEDAAN PENGARUH METODE PEMBELAJARAN TEKNIK DAN BERMAIN TERHADAP HASIL BELAJAR TOLAK PELURU GAYA OBREIN PADA SISWA KELAS 4 DAN 5 SD N 02 MALANGGATEN TAHUN PELAJARAN 2022/2023.
Authors: Totong Umar  , Ronny Suryo Narbito  , Devina Dwi Anggarita  
Published: February 2024

Tujuan penelitian untuk mengetahui Perbedaan Pengaruh Metode Pembelajaran Teknik dan Bermain Terhadap Hasil Belajar Tolak Peluru Gaya Obrein Pada siswa kelas 4 dan 5 SD N 02 Malanggaten Tahun Pelajaran 2022/2023, dan jika ada perbedaan maka untuk mengetahui mana yang lebih baik antara Metode Pembelajaran Teknik dan Bermain Terhadap Hasil Belajar Tolak Peluru Gaya Obrein Pada siswa kelas 4 dan 5 SD N 02 Malanggaten Tahun Pelajaran 2022/2023. Sampel penelitian adalah siswa kelas 4 dan 5 SD N 02 Malanggaten Tahun Pelajaran 2022/2023 dengan jumlah 30 siswa. Pengambilan sampel menggunakan teknik Total Sampling. Variabel penelitian ini yaitu hasil Tolak Peluru Gaya Obrein dengan Metode Pembelajaran Teknik dan Bermain sebagai variabel bebas serta hasil Hasil Belajar Tolak Peluru Gaya Obrein variabel terikat. Rancangan penelitian menggunakan pretest-posttest design. Tes untuk mengetahui Tolak Peluru Gaya obrien menggunakan tes Tolak Peluru Gaya obrien menggunakan petunjuk pelaksanaan tes dari Pusat pengembangan kualitas jasmani, departemen pendidikan nasional (1999:16). Metode analisis data penelitian menggunakan rumus t-test yang diperhitungkan menggunakan rumus pendek.
Hasil analisis data maka simpulan diperoleh: (1) Ada perbedaan pengaruh yang signifikan antara Pembelajaran teknik Dan Pembelajaran bermain Terhadap Hasil Belajar Tolak Peluru Gaya Obrein Pada siswa kelas 4 dan 5 SD N 02 Malanggaten Tahun Pelajaran 2022/2023. Hal ini dibuktikan dari hasil penghitungan tes akhir masing-masing kelompok yaitu thitung = 4.814 lebih kecil dari pada ttabel = 2,145 dengan taraf signifikasi 5%. (2) Metode Pembelajaran teknik lebih baik pengaruhnya dari pada metode pembelajaran bermain Terhadap Hasil Belajar Tolak Peluru Gaya Obrein Pada siswa kelas 4 dan 5 SD N 02 Malanggaten Tahun Pelajaran 2022/2023. Berdasarkan persentase peningkatan Hasil Belajar Tolak Peluru Gaya Obrein Pada siswa kelas 4 dan 5 SD N 02 Malanggaten Tahun Pelajaran 2022/2023 menunjukkan bahwa kelompok 1 (kelompok yang mendapat perlakuan dengan Pembelajaran Teknik) adalah 14.010% > kelompok 2 (kelompok yang mendapat Pembelajaran bermain ) adalah 12.139%.
Kata Kunci: Metode Pembelajaran Teknik, Bermain, Tolak Peluru Gaya Obrein