bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE IMPACT OF 3 GENERATIONS OF VIOLENCE ON THE MENTAL HEALTH OF COLOMBIAN OLDER ADULTS: COMPARATIVE MULTI-SITE SURVEY
Authors: Gabbay Mark , Zuluaga Maria Isabel , Saldarriaga-ruiz gabriel , Montoya Erika , Giebel Clarissa 
Published: December 2023

Abstract
Endemic violence across Colombia for 70 years has displaced generations of the poorest among Colombian society particularly in (semi)rural and peri-urban settings, approximately (10m- 20% total population). In 2022, 12.5% (1.2m) were older adults living with the health and socioeconomic consequences, losses and life-changing disruptions. Our joint Colombian UK-funded project in Turbo explores ways to co-produce and pilot an intervention to help mitigate impacts older-adults’ mental-health and wellbeing. This survey explores their burden of ill-health and adversity. We compared our 2022 older-adults survey in Turbo ( n=611) with 2016 (n=~0.5m) survey findings from three other Colombian regions with different exposures to ‘La Violencia’. Both surveys measured Cognitive status, Functionality, Autonomy, Depression, Anxiety, Alcohol-use, Well-being, Social support, Loneliness, Nutrition and Maltreatment plus demographics and used probability cluster two-stage sampling to enhance representativeness. Mental health is not a concept used by older adults, ‘depression’ (5-28%) and ‘anxiety’ (4-21%) were lower than anticipated. An unexpectedly high proportion in Turbo respondents had at least some cognitive deficit (62%), much higher than elsewhere (1.3-5.1%). Most respondents were living in significant poverty with low educational attainment, low or minimal income, low nutrition, poor housing and social isolation. Reported elder abuse rates ranged from 4-30% across sites. The survey findings confirm high rates of vulnerability among older adults living with the severe consequences of ’La Violencia’ upon mental-health. Our project co-producing and delivering affordable and sustainable interventions, seeks to improve mental health and wellbeing, self-esteem and belonging, within a society that largely neglects older adults.
The effect of shear strain and shear localization on fault healing
Authors: Noël Corentin , Giorgetti Carolina , Collettini Cristiano , Marone Chris 
Published: December 2023

SUMMARY
The seismic cycle of repeated earthquake failure requires that faults regain frictional strength during the interseismic phase, when the fault is locked or undergoing quasi-static creep. Fault healing plays a central role in determining earthquake stress drop, recurrence interval, elastic radiation frequency and other source parameters. In particular, the longer a fault remains quasi-stationary, the stronger it becomes and the larger the potential stress drop can be for the next event. Here, we address the role of shear strain and strain localization on fault healing and healing rate. We performed slide-hold-slide friction experiments on quartz gouge in the double-direct shear configuration for shear strain up to 25 and hold times from 10 to 1000 s. The results show that both healing and healing rate increase nonlinearly with increasing shear strain. Frictional healing scales with volumetric strain within the laboratory fault zone. Using the volumetric strain upon reshear as a proxy for strain localization, we demonstrate that the capacity of a fault to heal is directly proportional to shear bandwidth and degree of strain localization. The more the deformation is localized, the higher are the healing and healing rate, and thus, the fault strength. Our data provide a framework for understanding variations in fault strength over the seismic cycle and the role of brecciation and strain localization on spatiotemporal variations in fault strength.
Mean Field Approximations via Log-Concavity
Authors: Lacker Daniel , Mukherjee Sumit , Yeung Lane Chun 
Published: December 2023

Abstract
We propose a new approach to deriving quantitative mean field approximations for any probability measure $P$ on $\mathbb {R}^{n}$ with density proportional to $e^{f(x)}$, for $f$ strongly concave. We bound the mean field approximation for the log partition function $\log \int e^{f(x)}dx$ in terms of $\sum _{i \neq j}\mathbb {E}_{Q^{*}}|\partial _{ij}f|^{2}$, for a semi-explicit probability measure $Q^{*}$ characterized as the unique mean field optimizer, or equivalently as the minimizer of the relative entropy $H(\cdot \,|\,P)$ over product measures. This notably does not involve metric-entropy or gradient-complexity concepts which are common in prior work on nonlinear large deviations. Three implications are discussed, in the contexts of continuous Gibbs measures on large graphs, high-dimensional Bayesian linear regression, and the construction of decentralized near-optimizers in high-dimensional stochastic control problems. Our arguments are based primarily on functional inequalities and the notion of displacement convexity from optimal transport.
Efficacy, Safety, and Pharmacokinetics by Body Mass Index Category in Phase 3/3b Long-Acting Cabotegravir Plus Rilpivirine Trials
Authors: Elliot Emilie R , Polli Joseph W , Patel Parul , Garside Louise , Grove Richard , Barnett Vincent , Roberts Jeremy , Byrapuneni Sri , Crauwels Herta , Ford Susan L , Van Solingen-Ristea Rodica , Birmingham Eileen , D’Amico Ronald , Baugh Bryan , van Wyk Jean 
Published: December 2023

Abstract

Background
Cabotegravir plus rilpivirine (CAB + RPV) is a guideline-recommended long-acting (LA) injectable regimen for the maintenance of human immunodeficiency virus-1 (HIV-1) virologic suppression. This post hoc analysis summarizes CAB + RPV LA results by baseline body mass index (BMI) category among phase 3/3b trial participants.

Methods
Data from CAB + RPV-naive participants receiving every 4 or 8 week dosing in FLAIR, ATLAS, and ATLAS-2M were pooled through week 48. Data beyond week 48 were summarized by study (FLAIR through week 96 and ATLAS-2M through week 152). HIV-1 RNA &lt;50 and ≥50 copies/mL, confirmed virologic failure (CVF; 2 consecutive HIV-1 RNA ≥200 copies/mL), safety and tolerability, and plasma CAB and RPV trough concentrations were evaluated by baseline BMI (&lt;30 kg/m2, lower; ≥30 kg/m2, higher).

Results
Among 1245 CAB + RPV LA participants, 213 (17%) had a baseline BMI ≥30 kg/m2. At week 48, 92% versus 93% of participants with lower versus higher BMI had HIV-1 RNA &lt;50 copies/mL, respectively. Including data beyond week 48, 18 participants had CVF; those in the higher BMI group (n = 8) all had at least 1 other baseline factor associated with CVF (archived RPV resistance-associated mutations or HIV-1 subtype A6/A1). Safety and pharmacokinetic profiles were comparable between BMI categories.

Conclusions
CAB + RPV LA was efficacious and well tolerated, regardless of baseline BMI category.

Clinical Trials Registration
NCT02938520, NCT02951052, and NCT03299049.
Extended Postexposure Protection Against Vaginal Simian/Human Immunodeficiency Virus Infection With Tenofovir Alafenamide Fumarate/Elvitegravir Inserts in Macaques
Authors: Makarova Natalia , Singletary Tyana , Peet M Melissa , Mitchell James , Bachman Shanon , Holder Angela , Dinh Chuong , Lipscomb Jonathan , Agrahari Vivek , Mendoza Maria , Pan Yi , Heneine Walid , Clark Meredith R , García-Lerma J Gerardo , Doncel Gustavo F , Smith James M 
Published: December 2023

Abstract
Vaginal inserts that can be used on demand before or after sex may be a desirable human immunodeficiency virus (HIV) prevention option for women. We recently showed that inserts containing tenofovir alafenamide fumarate (TAF, 20 mg) and elvitegravir (EVG, 16 mg) were highly protective against repeated simian/human immunodeficiency virus (SHIV) vaginal exposures when administered to macaques 4 hours before or after virus exposure (93% and 100%, respectively). Here, we show in the same macaque model that insert application 8 hours or 24 hours after exposure maintains high efficacy (94.4% and 77.2%, respectively). These data extend the protective window by TAF/EVG inserts and inform their clinical development for on-demand prophylaxis in women.
Seroreversion to Chlamydia trachomatis Pgp3 Antigen Among Children in a Hyperendemic Region of Amhara, Ethiopia
Authors: Tedijanto Christine , Aragie Solomon , Gwyn Sarah , Wittberg Dionna M , Zeru Taye , Tadesse Zerihun , Chernet Ambahun , Thompson Isabel J B , Nash Scott D , Lietman Thomas M , Martin Diana L , Keenan Jeremy D , Arnold Benjamin F 
Published: December 2023

Abstract
Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a 3-year longitudinal cohort in a high-transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 per 100 person-years (95% confidence interval, 1.6–3.5).
Clinical Trials Registration NCT02754583.
Modulatory role of SmeQ in SmeYZ efflux pump-involved functions in Stenotrophomonas maltophilia
Authors: Hu En-Wei , Lu Hsu-Feng , Lin Yi-Tsung , Yang Tsuey-Ching , Li Li-Hua 
Published: December 2023

Abstract

Background
SmeYZ is a constitutively expressed efflux pump in Stenotrophomonas maltophilia. Previous studies demonstrated that: (i) smeYZ inactivation causes compromised swimming, oxidative stress tolerance and aminoglycoside resistance; and (ii) the ΔsmeYZ-mediated pleiotropic defects, except aminoglycoside susceptibility, result from up-regulation of entSCEBB′FA and sbiAB operons, and decreased intracellular iron level.

Objectives
To elucidate the modulatory role of SmeQ, a novel cytoplasmic protein, in ΔsmeYZ-mediated pleiotropic defects.

Methods
The presence of operons was verified using RT–PCR. The role of SmeQ in ΔsmeYZ-mediated pleiotropic defects was assessed using in-frame deletion mutants and functional assays. A bacterial adenylate cyclase two-hybrid assay was used to investigate the protein–protein interactions. Gene expression was quantified using quantitative RT–PCR (RT–qPCR).

Results
SmeYZ and the downstream smeQ formed an operon. SmeQ inactivation in the WT KJ decreased aminoglycoside resistance but did not affect swimming and tolerance to oxidative stress or iron depletion. However, smeQ inactivation in the smeYZ mutant rescued the ΔsmeYZ-mediated pleiotropic defects, except for aminoglycoside susceptibility. In the WT KJ, SmeQ positively modulated SmeYZ pump function by transcriptionally up-regulating the smeYZQ operon. Nevertheless, in the smeYZ mutant, SmeQ exerted its modulatory role by up-regulating entSCEBB′FA and sbiAB operons, decreasing intracellular iron levels, and causing ΔsmeYZ-mediated pleiotropic defects, except for aminoglycoside susceptibility.

Conclusions
SmeQ is the first small protein identified to be involved in efflux pump function in S. maltophilia. It exerts modulatory effect by transcriptionally altering the expression of target genes, which are the smeYZQ operon in the WT KJ, and smeYZQ, entSCEBB′FA and sbiAB operons in smeYZ mutants.
Unveiling galaxy morphology through an unsupervised-supervised hybrid approach
Authors: Kolesnikov I , Sampaio V M , de Carvalho R R , Conselice C , Rembold S B , Mendes C L , Rosa R R 
Published: December 2023

ABSTRACT
Galaxy morphology offers significant insights into the evolutionary pathways and underlying physics of galaxies. As astronomical data grow with surveys such as Euclid and Vera C. Rubin, there is a need for tools to classify and analyse the vast numbers of galaxies that will be observed. In this work, we introduce a novel classification technique blending unsupervised clustering based on morphological metrics with the scalability of supervised Convolutional Neural Networks. We delve into a comparative analysis between the well-known CAS (Concentration, Asymmetry, and Smoothness) metrics and our newly proposed EGG (Entropy, Gini, and Gradient Pattern Analysis). Our choice of the EGG system stems from its separation-oriented metrics, maximizing morphological class contrast. We leverage relationships between metrics and morphological classes, leading to an internal agreement between unsupervised clustering and supervised classification. Applying our methodology to the Sloan Digital Sky Survey data, we obtain ∼95 per cent of Overall Accuracy of purely unsupervised classification and when we replicate T-Type and visually classified galaxy catalogues with accuracy of ∼88 and ∼89 per cent, respectively, illustrating the method’s practicality. Furthermore, the application to Hubble Space Telescope data heralds the potential for unsupervised exploration of a higher redshift range. A notable achievement is our ∼95 per cent accuracy in unsupervised classification, a result that rivals when juxtaposed with Traditional Machine Learning and closely trails when compared to Deep Learning benchmarks.
FlexKnot and Gaussian Process for 21 cm global signal analysis and foreground separation
Authors: Heimersheim Stefan , Rønneberg Leiv , Linton Henry , Pagani Filippo , Fialkov Anastasia 
Published: December 2023

ABSTRACT
The cosmological 21 cm signal is one of the most promising avenues to study the Epoch of Reionization. One class of experiments aiming to detect this signal is global signal experiments measuring the sky-averaged 21 cm brightness temperature as a function of frequency. A crucial step in the interpretation and analysis of such measurements is separating foreground contributions from the remainder of the signal, requiring accurate models for both components. Current models for the signal (non-foreground) component, which may contain cosmological and systematic contributions, are incomplete and unable to capture the full signal. We propose two new methods for extracting this component from the data: First, we employ a foreground-orthogonal Gaussian Process to extract the part of the signal that cannot be explained by the foregrounds. Secondly, we use a FlexKnot parametrization to model the full signal component in a free-form manner, not assuming any particular shape or functional form. This method uses Bayesian model selection to find the simplest signal that can explain the data. We test our methods on both, synthetic data and publicly available EDGES low-band data. We find that the Gaussian Process can clearly capture the foreground-orthogonal signal component of both data sets. The FlexKnot method correctly recovers the full shape of the input signal used in the synthetic data and yields a multimodal distribution of different signal shapes that can explain the EDGES observations.
Global deletome profile of Saccharomyces cerevisiae exposed to lithium
Authors: Fierling Nicolas , Billard Patrick , Bauda Pascale , Blaudez Damien 
Published: December 2023

Abstract
The increasing use of lithium (Li) in new technologies raises the question of its impact on living microorganisms. In the present study, we aimed to identify putative Li targets and resistance mechanisms in the yeast model Saccharomyces cerevisiae using a deletomic approach based on the screening of a collection of 4733 knockout mutants under Li exposure. This screening highlighted 60 mutants resistant to Li and 124 mutants sensitive to Li. Through functional enrichment analyses, transport systems were identified as playing a central role in cell resistance to toxic concentrations of Li. In contrast, the AKT/protein kinase B family, signal transduction or cell communication were identified as potential toxic targets of Li. The majority of the mutants with a Li-sensitive phenotype were also sensitive to other alkali and alkaline earth metals, whereas the Li-resistance phenotype was mostly resistant to Na but poorly resistant to other metals. A comparison with the results of deletomics studies carried out in the presence of other metals highlighted Li-specific phenotypes. Three genes (NAM7, NMD2, UPF3) of the nonsense-mediated decay pathway were specifically involved in resistance to Li. In contrast, mutants with the NCA2, SPT20, GCN5, YOR376W, YPK3, and DCW1 genes deleted were specifically resistant to Li. These genes encode various functions from putative mannosidase to constitution of the Spt-Ada-Gcn5 acetyltransferase complex. This work provides a better understanding of potential specific resistance mechanisms and cellular targets of Li in yeast.
Oral COVID-19 Antiviral Uptake Among a Highly Vaccinated US Cohort of Adults With SARS-CoV-2 Infection Between December 2021 and October 2022
Authors: Shen Yanhan , Robertson McKaylee M , Kulkarni Sarah G , Puzniak Laura , Zamparo Joann M , Allen Kristen E , Porter Thomas M , Qasmieh Saba A , Grov Christian , Srivastava Avantika , Zimba Rebecca , McLaughlin John M , Nash Denis 
Published: December 2023

Abstract

Background
We described the oral nirmatrelvir/ritonavir (NMV/r) and molnupiravir (MOV) uptake among a subgroup of highly vaccinated adults in a US national prospective cohort who were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between 12/2021 and 10/2022.

Methods
We estimate antiviral uptake within 5 days of SARS-CoV-2 infection, as well as age- and gender-adjusted antiviral uptake prevalence ratios by antiviral eligibility (based on age and comorbidities), sociodemographic characteristics, and clinical characteristics including vaccination status and history of long coronavirus disease 2019 (COVID).

Results
NMV/r uptake was 13.6% (95% CI, 11.9%–15.2%) among 1594 participants, and MOV uptake was 1.4% (95% CI, 0.8%–2.1%) among 1398 participants. NMV/r uptake increased over time (1.9%; 95% CI, 1.0%–2.9%; between 12/2021 and 3/2022; 16.5%; 95% CI, 13.0%–20.0%; between 4/2022 and 7/2022; and 25.3%; 95% CI, 21.6%–29.0%; between 8/2022 and 10/2022). Participants age ≥65 and those who had comorbidities for severe COVID-19 had higher NMV/r uptake. There was lower NMV/r uptake among non-Hispanic Black participants (7.2%; 95% CI, 2.4%–12.0%; relative to other racial/ethnic groups) and among individuals in the lowest income groups (10.6%; 95% CI, 7.3%–13.8%; relative to higher income groups). Among a subset of 278 participants with SARS-CoV-2 infection after 12/2021 who also had a history of prior SARS-CoV-2 infection, those with (vs without) a history of long COVID reported greater NMV/r uptake (22.0% vs 7.9%; P = .001). Among those prescribed NMV/r (n = 216), 137 (63%; 95% CI, 57%–70%) reported that NMV/r was helpful for reducing COVID-19 symptoms.

Conclusions
Despite proven effectiveness against severe outcomes, COVID-19 antiviral uptake remains low among those with SARS-CoV-2 infection in the United States. Further outreach to providers and patients to improve awareness of COVID-19 oral antivirals and indications is needed.
Clinical Setting Comparative Analysis of Uropathogens and Antibiotic Resistance: A Retrospective Study Spanning the Coronavirus Disease 2019 Pandemic
Authors: Young Alexandra M , Tanaka Mark M , Yuwono Christopher , Wehrhahn Michael C , Zhang Li 
Published: December 2023

Abstract

Background
Antimicrobial resistance (AMR) in uropathogens has been increasing in Australia. Many nations observed heightened AMR during the coronavirus disease 2019 (COVID-19) pandemic, but it is not known how this may vary across clinical settings and in nations with lower infection rates.

Methods
We investigated the uropathogen composition and corresponding antibiotic resistance of 775 559 Australian isolates from the community, hospitals, and aged care facilities before (2016–2019) and during (2020–2022) the COVID-19 pandemic. A mathematical model was developed to predict the likelihood of resistance to currently recommended antibiotics for treating urinary tract infections (UTIs).

Results
Among uropathogens originating from the community, hospitals, and aged care facilities, Escherichia coli accounted for 71.4%, 57.6%, and 65.2%, respectively. During the COVID-19 pandemic period, there was an increase in UTIs caused by E coli across all settings. Uropathogens from aged care and hospitals frequently showed higher resistance to antibiotics compared to those isolated from the community. Interestingly, AMR among uropathogens showed a declining trend during the COVID-19 pandemic. Based on the resistance patterns of the past 3 years, our modeling predicted that 30%, 42.6%, and 38.8% of UTIs in the community, hospitals, and aged care facilities, respectively, would exhibit resistance to trimethoprim treatment as empirical therapy. In contrast, resistance to nitrofurantoin was predicted to be 14.6%, 26%, and 24.1% from these 3 respective settings.

Conclusions
Empirical therapy of UTIs in Australia with trimethoprim requires evaluation due to high rates of resistance observed across clinical settings.
Transarterial Radioembolization for Management of Hepatocellular Carcinoma
Authors: Badar Wali , Yu Qian , Patel Mikin , Ahmed Osman 
Published: December 2023

Abstract
Transarterial radioembolization (TARE) with Yttrium-90 (Y90) is a growing area of study due to its benefits in early-, intermediate-, and late-stage hepatocellular carcinoma. Treatment intent, including curative therapy, bridging to transplant, and downstaging disease, informs treatment approach and dosimetry goals. Radiation lobectomy (RL) and radiation segmentectomy (RS) are the 2 main forms of Y90 administration which have shown improved survival outcomes with the development of personalized dosimetry. RS aims to achieve complete pathological necrosis with dose escalation and RL aims for local disease control as well as induction of contralateral lobe hypertrophy to improve hepatic reserve. Furthermore, TARE has been validated in head-to-head comparison to other locoregional and systemic therapies. Lastly, early potential exists for combination therapy between TARE and immune checkpoint inhibitors for advanced stage disease.
Foreign Irrevocable Trusts and Taxes on Wealth in Argentina: Comment on Volij, Gabriela V. v Argentine Tax Authorities on Law Nr. 27,605, of the First Instance Federal Contentious Administrative Court Nr. 8 of Buenos Aires City
Authors: Malumián Nicolás 
Published: December 2023

Abstract
An Argentine individual created an irrevocable trust in New Zealand with three protectors. Argentina enacted a one-time extraordinary tax over the assets of all individuals on 18 December 2020. This tax included in its base for calculation all assets transferred to trusts abroad. The Judge declared that assets transferred to irrevocable trusts are no longer property of the settlor and could not be taxed.