bluuebunny/crossref_metadata_2025_split huggingface dataset:
How a Medically Tailored Meal Intervention with Intensive Nutrition Counseling Created Active Coping with Behavior Change for Vulnerable Patients with Lung Cancer
Authors: Rothpletz-Puglia Pamela , Smith Jade , Pavuk Chloe , Leotta Jana , Pike Kimberli , Presley Carolyn J. , Krok-Schoen Jessica , Braun Ashlea , Cohen Mary Kathryn , Rogers Gail T , Kwan Ho Kenneth Chui , Zhang Fang Fang , Spees Colleen 
Published: February 2024

Abstract
Purpose
The purpose of this study was to assess participants’ perceptions and experiences while participating in a Food is Medicine medically tailored meal plus nutrition counseling intervention to create a theoretical explanation about how the intervention worked.
Methods
This interpretive qualitative study included the use of semi-structured interviews with active intervention participants. Purposeful sampling included vulnerable (uninsured, rural zip code residency, racial/ethnic minority, 65 years old, and/or low-income) individuals with lung cancer treated at four cancer centers across the United States. Interviews were recorded, transcribed verbatim, and analyzed using conventional content analysis with principles of grounded theory.
Results
Twenty individuals participated. Data analysis resulted in a theoretical explanation of the intervention’s mechanism of action. The explanatory process includes 3 linked and propositional categories leading to patient resilience: engaging in treatment, adjusting to diagnosis, and active coping. The medically tailored meals plus intensive nutrition counseling engaged participants throughout treatment, which helped participants adjust to their diagnosis, leading to active coping through intentional self-care, behavior change, and improved quality of life.
Conclusions
These findings provide evidence that a food is medicine intervention may buffer some of the adversity related to the diagnosis of lung cancer and create a pathway for participants to experience post-traumatic growth, develop resilience, and change behaviors to actively cope with lung cancer. Medically tailored meals plus intensive nutrition counseling informed by motivational interviewing supported individuals’ adjustment to their diagnosis and resulted in perceived positive behavior change.
Early experience of uniportal robotic assisted anatomic resection in lung cancer patients: Is it safe and feasible direct transition from uniportal video thoracoscopic assisted surgery to uniportal robotic assisted surgery?
Authors: Wu Ching Feng , Hsieh Ming Ju , Gonzalez-Rivas Diego , Yang Tzu Yi , Lin Yi Yu , Wu Ching Yang 
Published: February 2024

Abstract
Background
To share our experience and short outcome of uniportal robotic-assisted thoracic surgery (U-RATS) hybrid method in lung cancer patients
Methods:
A retrospective study was conducted to compare the feasibility of U-RATS in lung cancer patients. From August 2023 to December 2023, 15 patients with 16 lung cancers were enrolled in this study. The perioperative and 30-day short term outcomeresults were collected.
Results:
Perioperative outcomes were gathered in this study, including the length of hospital stay and the rate of post-operative (post-op) complications. The mean docking time of URATS was , mean intraoperative blood loss was mL, mean post-op hospital stay was 3.05 days, and the thoracic drainage of the first day after surgery were 230.9 vs. 207.1 mL. The visual analogue scale (VAS) scales after surgery and on the discharge day were 2.4 ±0.6 and 1.6±1.3. No perioperative and 30-day mortality occurred in our retrospective study. There was no conversion case to multiport robotic assisted thoracoscopic surgery (RATS) or thoracotomy in our series.
Conclusion:
U-RATS is a feasible treatment option for lung cancer patients as long as Console surgeon and cart surgeon with excellent communication skills and extensive training experience in uniport video -assisted thoracoscopic surgery (U-VATS) and comprehensive RATS training.
Improving accuracy and reliability of an electrochemical impedance spectroscopy aptamer-based biosensor
Authors: de Amorim Renê Santos , Serrano Pablo A. , Nunes Gisele E. , Bechtold Ivan H. 
Published: February 2024

Abstract
Impedance-based biosensors are effective tools for rapid and specific detection. However, they often rely solely on charge transfer resistance as an indicator of surface structural changes upon analyte binding and other valuable data are constantly ignored. In this work we explore different data obtained for a biosensor designed for water toxin (Saxitoxin) detection using electrochemical impedance spectroscopy. We established a safe potential range for ensuring sensor stability using cyclic voltammetry and determined the potential where the constant phase element values were more pronounced. The data showed that capacitance values could not reliably evaluate the system due to their high deviations. The impedance modulus (Z) revealed the highest number of acceptable frequencies and the values of the imaginary impedance (-Z") exhibited signal differences exceeding 30%, indicating their potential for signal enhancement during saxitoxin detection. The relative standard deviation can be reduced by increasing the concentration of the redox probe. The obtained results highlight the importance of carefully selecting parameters for characterizing the electrochemical behavior of the system to identify the most reliable and informative parameters for detection. This research contributes to broader electrochemistry sensing applications, opening new horizons for improving the accuracy and reliability of electrochemical analysis.
Analysis of water losses in seven small and medium-sized water distribution networks in the south region of Cameroon (Central Africa)
Authors: Mvongo Victor Dang , Defo Celestin , Nguema Paul Fabrice , Efon Boniface , Mbeyi Jeanne Gabriella Ondigui 
Published: February 2024

Abstract

This paper analyzes and evaluates water losses in seven small and medium-sized water supply networks in the south region of Cameroon in order to contribute to improving the most effective approaches to reducing water losses in Sub-Saharan Africa's water supply networks. Water losses were analyzed using a variety of indices as well as indices recommended by the International Water Association. The results lead to the conclusion that all the water supply networks achieved mixed results compared to national data and very weak results compared to international standards. The failure intensity index didn’t perform well for all the analyzed water supply networks, leading to the conclusion that the water supply networks studied are not technically in good condition. The percentage water loss indices for all the water supply networks range from 6.06–87.25%. Only the Ambam water supply network performed well in terms of unit water loss. The non-revenue water basic index values in all the studied water supply networks range from 18.37–92.21%. The real leakage balance index in all the studied water supply networks ranges from 27.31 to 2,916.30 dm3/connection/day. Results also suggest that the infrastructure leakage index ranged from 0.02 to 122.65 and that there is a need for improvement to enhance profitability with better network pressure management, active leakage control, and network maintenance. This assessment, however, offers only a current snapshot of the status of water loss in the water supply networks analyzed and should be repeated at regular intervals to follow changes in general and local conditions.
Therapeutic Effect of Resveratrol and its Novel Formulations on
Lung Cancer: Focus on Biological Aspects and Underlying Pathways
Authors: Poortalebi Hamidreza , ZareDini Mahta , Foroughi-Nematollahi Sima , Farkhondeh Tahereh , Samarghandian Saeed , Pourhanifeh Mohammad Hossein 
Published: February 2024

Abstract:
Lung cancer is a leading cause of mortality and morbidity worldwide. Due to
significant advances in therapeutic strategies, patients' survival and life quality have
been improved, however there is still an urgent requirement for developing more effective
therapeutic methods. Resveratrol, a natural polyphenol with numerous biological potentials,
has been widely studied. It has shown therapeutic potetial in various diseases including
neurodegenerative diseases, cardiovascular disorders, and cancers through the
regulation of key cellular signaling such as apoptosis, as well as molecular pathways
such as microRNA modulation. It has been reported that resveratrol acts as an anticancer
agent against lung cancer in vivo and in vitro. Resveratrol could combat against
lung cancer by modulating various molecular targets and signaling pathways involved in
oxidative stress, inflammation, apoptosis and autoghagy and also microRNAs expression.
Moreover, novel delivery systems and analogs have recently been introduced to
promote the anticancer impacts of resveratrol. In this article, we review current evidence
on the anticancer effects of resveratrol and its novel formulations in the treatment of
lung cancer with a focus on underlying mechanisms.
N-Acylhydrazone Pharmacophore's Analgesic and Anti-inflammatory Profile:
Recent Advancements during the Past Ten Years
Authors: Kassab Asmaa E. 
Published: February 2024

Abstract:
Due to its important biological and pharmacological properties, in the field of medicinal chemistry
and drug discovery, the N-acylhydrazone motif has shown to be extremely adaptable and promising. This scaffold
has become a crucial component in the synthesis of numerous bioactive agents. N-Acylhydrazones are also
interesting biological and synthetic tools due to their easy and straightforward synthesis. The current review
provides a summary of the analgesic and anti-inflammatory activities of N-acylhydrazone derivatives over the
past ten years. A brief discussion of structure-activity relationships is also provided which may guide researchers
in medicinal chemistry to develop derivatives based on N-acylhydrazone scaffold as potent anti-inflammatory
candidates.
Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A
Recent Update
Authors: Jaiswal Shivangi , Dwivedi Jaya , Kishore Dharma , Sharma Swapnil 
Published: February 2024

Abstract:
Tetrazole is a most versatile pharmacophore of which more than twenty FDAapproved
drugs have been marketed globally for the management of various diseases. In
spite of many remarkable and consistent efforts having been made by the chemists towards
the development of greener and sustainable strategies for the synthesis of tetrazole derivatives,
this approach still needs more attention. The present review focuses on the green synthetic
approach for the preparation of tetrazole derivatives from different starting materials
such as nitrile, isonitrile, carbonyl, amine, amide, oxime and terminal alkyne functions. The
mechanism of tetrazole synthesis from different substrates is discussed. In addition to this, a
four component Ugi-azide reaction to the tetrazole synthesis is also described. Of note, the
present articles exploited several water-mediated and solvent-free methodologies for tetrazole
synthesis. The important key features of tetrazole synthesis were pinpointing in each synthetic scheme
which provides excellent guide to those searching for selective procedure to achieve the desired transformation.
This review seeks to present a timely account (2011-2023) on the splendid array of ecofriendly procedures of
synthesis known today for the preparation of tetrazole derivatives from different starting materials. The rational
of this review is to enlighten recent advancements in the synthesis of tetrazole derivatives from different substrates.
Metal-Free Selective para-Tosyloxylation of N-Arylbenzamides using [Hydroxy(tosyloxy)iodo]benzene
Authors: Rani Neha , Aneja Deepak Kumar , Kinger Mayank , Soni Rinku , Sihag Monika , Malik Sandeep 
Published: February 2024

Abstract:
An efficient approach for the tosyloxyl group transfer in several N-arylbenzamides has been
achieved using HTIB (Koser’s reagent) under mild reaction conditions. Its simplicity, efficiency, and
reduced reliance on hazardous reagents make it an attractive choice for chemists seeking sustainable
alternatives. The proposed methodology offered single-step para-selective tosyloxylation, ensuring the
prevention of the synthesis of mixtures of ortho and meta-isomers. The corresponding products were
obtained with moderate to excellent efficiency. The current approach eliminated the need for harsh,
acidic, and toxic metals, ensuring safer handling and minimizing environmental impact. A plausible
mechanism for tosyloxylation of N-arylbenzamides involving iodonium ylide has been proposed.
Clinical Analysis of Resemblance and Dissimilarities of Glucagon-like Peptide-1 Receptor Agonists: Therapeutic Approach Towards the Management of Diabetes Mellitus
Authors: Sashi  , Rani Kajal , Rani Komal , Ankita  , Mittal Vineet , Kaushik Deepak , Dhall Manish , Bamrah Prabhjeet Kaur , Kumar Tarun , Pandey Manisha , Jain Neha , Arya Ashwani 
Published: February 2024

Abstract:
One of the classes of injective antidiabetic agents includes Glucagon-like peptide-1 receptor
agonists (GLP-1RA) which ameliorate glycemia and numerous atherosclerosis-related factors in
individuals prone to Type 2 diabetes mellitus (T2-DM) disorder.

Methods:
The review paper targeted the role of GLP-1RA in managing DM. The literature published
during the last decades in several data-based searches (PubMed, Scopus, ScienceDirect) was reviewed
and compiled the therapeutic uses of GLP-1 RA in the management of DM. In this review,
we have discussed GLP-1RA and its role in the management of diabetes mellitus.

Results and Discussion:
Disrupted homeostasis marks insulin resistance and β-cell deterioration as
two major indications of T2-DM. β-cells failure (~80% of functioning of β-cell) and insulin resistance
in the liver and muscles are primarily susceptive to physiological defects. GLP-1RAs if administered
for a prolonged period also cause a loss in weight through the activation of receptors of GLP-1 found
in hypothalamic satiety centers which control appetite and decrease intake of calories. They not only
assist in controlling blood glucose but also improve β- cell function and post–diabetic conditions
namely hyperlipidemia, obesity, and hypertension.

Conclusion:
It was concluded that GLP-1RA has a new therapeutic approach to the management of
DM. Hence, GLP-1RA provides distinctive and innovative evolution for the treatment of T2-DM.
Role of Chronotherapy in the Management of Hypertension: An Overview
Authors: Raj Ritik , Mazumder Rupa , Mishra Rakhi , Mishra Rashmi , Singh Baghel Dileep 
Published: February 2024

:
The rise in age-adjusted mortality rates from hypertension and hypertensive diseases over
the last several years suggests that hypertension is one of the main risk factors for heart disease. As a
result, managing hypertension, both via preventive and therapeutic medicine, involves a heavy socioeconomic
burden. This review paper's objective is to summarize information on chronotherapy techniques,
which can make it possible for an active component to be distributed predictably and at a pace
that may also minimize the patient’s illness symptoms. To incorporate published research and review
papers, a comprehensive review of the literature from many sources during the past 25 years was
conducted. This paper summarizes the principle and method of the chronotherapy technique. The
review also throws light on different approaches that could be used to meet the need for medication
for the hypertensive patient according to the circadian cycle. From the study, it was concluded that
different formulation approaches are there that can work according to the principle of chronotherapy
with improvement in drug bioavailability and patient compliance. To encourage future researchers to
include chronotherapy in the creation of additional formulations, this review study intends to shed
light on various benefits and methods of chronotherapy.
Targeting Breast Cancer with N-Acetyl-D-Glucosamine: Integrating Machine Learning
and Cellular Assays for Promising Results
Authors: Baysal Ömür , Genç Deniz , Silme Ragıp Soner , Kırboğa Kevser Kübra , Çoban Dilek , Ghafoor Naeem Abdul , Tekin Leyla , Bulut Osman 
Published: February 2024

Background:
Breast cancer is a common cancer with high mortality rates. Early diagnosis is crucial
for reducing the prognosis and mortality rates. Therefore, the development of alternative treatment options is
necessary.

Objective:
This study aimed to investigate the inhibitory effect of N-acetyl-D-glucosamine (D-GlcNAc) on breast
cancer using a machine learning method. The findings were further confirmed through assays on breast cancer
cell lines.

Methods:
MCF-7 and 4T1 cell lines (ATCC) were cultured in the presence and absence of varying concentrations
of D-GlcNAc (0.5 mM, 1 mM, 2 mM, and 4 mM) for 72 hours. A xenograft mouse model for breast cancer was
established by injecting 4T1 cells into mammary glands. D-GlcNAc (2 mM) was administered intraperitoneally to
mice daily for 28 days, and histopathological effects were evaluated at pre-tumoral and post-tumoral stages.

Results:
Treatment with 2 mM and 4 mM D-GlcNAc significantly decreased cell proliferation rates in MCF-7
and 4T1 cell lines and increased Fas expression. The number of apoptotic cells was significantly higher than
untreated cell cultures (p < 0.01 - p < 0.0001). D-GlcNAc administration also considerably reduced tumour size,
mitosis, and angiogenesis in the post-treatment group compared to the control breast cancer group (p < 0.01 - p <
0.0001). Additionally, molecular docking/dynamic analysis revealed a high binding affinity of D-GlcNAc to the
marker protein HER2, which is involved in tumour progression and cell signalling.

Conclusion:
Our study demonstrated the positive effect of D-GlcNAc administration on breast cancer cells,
leading to increased apoptosis and Fas expression in the malignant phenotype. The binding affinity of D-GlcNAc
to HER2 suggests a potential mechanism of action. These findings contribute to understanding D-GlcNAc as a
potential anti-tumour agent for breast cancer treatment.
Synthesis of a Novel Gold(I) Complex and Evaluation of Its Anticancer Properties in
Breast Cancer Cells
Authors: Khan Haseeb Ahmad , Isab Anvarhusein Abdulkadir , Alhomida Abdullah Saleh , Gatasheh Mansour Khalil , Alhoshani Ali Rashid , Aldhafeeri Bashayr Ahmed , Prasad N Rajendra 
Published: February 2024

Background:
Platinum complexes are commonly used for cancer chemotherapy; however, they are not
only highly-priced but also have various side effects. It is, therefore, important to design affordable anticancer
drugs with minimal side effects.

Methods:
We synthesized a new gold(I) complex, PF6{(BDPEA)(TPPMS) digold(I)} (abbreviated as PBTDG)
and tested its cytotoxicity in MCF-7 breast cancer cells. We also evaluated the effects of PBTDG on mitochondrial
membrane potential, generation of reactive oxygen species (ROS) and apoptosis in breast cancer cells.

Results:
The IC50 values for PBTDG and sorafenib were found to be 1.48 μM and 4.45 μM, respectively. Exposure
to PBTDG caused significant and concentration-dependent depletion of ATP and disruption of mitochondrial
membrane potential. PBTDG induced 2.6, 3.6, and 5.7-fold apoptosis for 1 μM, 3 μM, and 10 μM concentrations,
respectively. The induction of apoptosis by the same concentrations of sorafenib was 1.2, 1.3, and 1.6-fold, respectively.
The low concentration of PBTDG (1 μM) induced the generation of ROS by 99.83%, which was
significantly higher than the ROS generation caused by the same concentration of sorafenib (73.76%). The ROS
induction caused by higher concentrations (5 μM) of PBTDG and sorafenib were 104.95% and 122.11%, respectively.

Conclusion:
The lower concentration of PBTDG produced similar cytotoxicity and apoptotic effects that were
caused by a comparatively higher concentration of known anticancer drug (sorafenib). The anticancer effects of
PBTDG are attributed to its tendency to disrupt mitochondrial membrane potential, induction of apoptosis and
generation of ROS. Further studies are warranted to test the anticancer effects of PBTDG in animal models of
cancer.
Current Drug Delivery Strategies to Design Orally Dissolving
Formulations to Target Tuberculosis: A Futuristic Review
Authors: Chowrasia Pinky , Singh Mohini , Jana Bani Kumar , Bora Pankaj Lochan , Mahato Ranjit Kumar , Kharbithai Rikynjai , Gogoi Niva Rani , Sarkar Tumpa , Pal Paulami , Mazumder Bhaskar 
Published: February 2024

Abstract:
All the standard anti-tubercular drugs, well established as standard therapy, are preferentially
available in formulations compliant with the young adult population. However, their use
in the paediatric and geriatric populations is confronted with issues, such as a high likelihood of
incorrect dose administration due to practices like dosage form fracture and splitting. This may
lead to drug resistance due to misuse and in-accurate dosage administration, the most dreaded and
difficult-to-treat stage of tuberculosis.

:
Poor patient compliance and adherence are major issues with the conventional line of therapy.
This burden may be more significant in resource-constrained settings, necessitating the creation
of simple formulations that are both geriatric and child-friendly. An extensive literature survey
has been conducted in this study using databases of Google Scholar, PubMed, and Research Gate,
with a focus on specific research works on oro-dispersible films, tablets, and wafer technology
loaded with anti-tuberculosis drugs from 2022 to 2010.

:
Mouth dissolving formulation technology is a very novel approach in the arena of tuberculosis
therapy. This may pave the way for future researchers to develop different mouth dissolving formulations
to treat both pulmonary and extra-tuberculosis. This review paper has summarized all
the formulation approaches alongside the present state of the art in tuberculosis therapy using
mouth dissolving formulations.
Development of Phytoconstituents from Spathodea campanulata Flowers as
Potential Antimalarial Agents
Authors: Geevarghese Abin V. , Emimmal Maida E.S. , Elizabeth Ida C.V. , Krishnan Poovarasan , Sumathi Sarulatha M. , Perumal Thirumal 
Published: February 2024

Background:
Considering the majority of pharmaceutical firms focus on using herbal
remedies as an alternative source of essential components, herbal remedies are extremely significant
to pharmacological researchers. Spathodea campanulata is one of the members of the Bignoniaceae
family. It is popular for its curative properties

Aim:
This research aimed to assess the possibility of bioactive elements and antioxidant impacts of
the methanol fraction of Spathodea campanulata flowers.

Objectives:
The objective of this research was to assess the achievable bioactive elements and antioxidant impacts of the methanol fraction of Spathodea campanulata flowers.

Methods:
GC-MS was adopted to identify the phytoconstituents present in the extract. In the present
study, we utilized computational modelling with the Schrödinger Maestro 11.2 edition to make benefit of interactions among 42 bio-active components and anti-malarial targets (1LDG and 2ANL).

Results:
In the methanol extract of the Spathodea campanulata flowers, phytochemical research revealed the presence of terpenoids, glycosides, carbohydrates, steroids, and flavonoids. Forty-two
phytoconstituents, notably methyl-beta-d-galactopyranoside, 4-hydroxybenzoic acid, and 1,2-
ethanediol monobenzoate, were determined through GC-MS analysis. Docking analysis of 42 bioactive compounds demonstrated that 1,2-ethanediol mono benzoate, 4-hydroxy benzoic acid, and methyl.beta.-d-galactopyranoside had higher G-Scores with 1LDG and 2ANL.

Conclusion:
In this work, multiple phytoconstituents discovered in a methanol extract of the S. campanulata flower were determined. As a result of this research, four phytoconstituents from the flower
extracts may be created as an exciting new therapy for malaria.