bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing histopathological image classification of invasive ductal carcinoma using hybrid harmonization techniques
Authors: Abdallah Nassib , Marion Jean-Marie , Tauber Clovis , Carlier Thomas , Hatt Mathieu , Chauvet Pierre 
Published: November 2023

AbstractThis study aims to develop a robust pipeline for classifying invasive ductal carcinomas and benign tumors in histopathological images, addressing variability within and between centers. We specifically tackle the challenge of detecting atypical data and variability between common clusters within the same database. Our feature engineering-based pipeline comprises a feature extraction step, followed by multiple harmonization techniques to rectify intra- and inter-center batch effects resulting from image acquisition variability and diverse patient clinical characteristics. These harmonization steps facilitate the construction of more robust and efficient models. We assess the proposed pipeline’s performance on two public breast cancer databases, BreaKHIS and IDCDB, utilizing recall, precision, and accuracy metrics. Our pipeline outperforms recent models, achieving 90-95% accuracy in classifying benign and malignant tumors. We demonstrate the advantage of harmonization for classifying patches from different databases. Our top model scored 94.7% for IDCDB and 95.2% for BreaKHis, surpassing existing feature engineering-based models (92.1% for IDCDB and 87.7% for BreaKHIS) and attaining comparable performance to deep learning models. The proposed feature-engineering-based pipeline effectively classifies malignant and benign tumors while addressing variability within and between centers through the incorporation of various harmonization techniques. Our findings reveal that harmonizing variabilities between patches from different batches directly impacts the learning and testing performance of classification models. This pipeline has the potential to enhance breast cancer diagnosis and treatment and may be applicable to other diseases.
The change of healthcare service in Chinese patients with inflammatory bowel disease during the pandemic: a national multicenter cross-sectional study
Authors: Li Xiaofei , Wang Fang , Jia Yizhen , Zhou He , Shi Yanting , Tian Feng , Chen Yan , Liang Jie 
Published: November 2023

AbstractThe pandemic of COVID-19 was a major public health events and had a deeply impact on the healthcare acquired by patients with inflammatory bowel disease (IBD). The purpose of this study was to evaluate the long-term impacts on healthcare service in Chinese IBD patients under the dynamic zero-COVID strategy. The study was performed in the Inflammatory Bowel Disease Quality of Care Centers in mainland China in 2021. The data about the healthcare was collected by a 44-item questionnaire. Totally 463 were from ulcerative colitis (UC) patients and 538 from Crohn’s disease (CD) patients were included in the study. The pandemic impacted 37.5% patients on their treatment, and the biggest problem was unable to follow up timely (77.9%). There was a significant increase in healthcare costs in CD (P < 0.001) and no significant change in UC (P = 0.14) after the outbreak. Both UC and CD had an increase in the frequency of outpatient visits (UC 5.07 vs. 4.54, P = 0.001; CD 6.30 vs. 5.76, P = 0.002), and hospitalizations (UC 1.30 vs. 1.02, P < 0.001; CD 3.55 vs. 2.78, P < 0.001). The hospitalization rate in UC reduced slightly (40.2% vs. 42.8%, P = 0.423) after the outbreak, but it significantly increased in CD (75.8% vs. 67.8%, P = 0.004). The rate of biologics had significant increased (UC 11.2% vs. 17.7%, P = 0.005; CD 53.2% vs. 71.0%, P < 0.001). Besides, the proportion of people using telemedicine also increased from 41.6% to 55.1% (P < 0.001). However, 82.8% patients still preferred face-to-face visits. Recurrent outbreaks and the regular pandemic prevention and control policy had a long-term impact on medical care service for IBD patients. The preferred mode of healthcare was still face-to-face visit. It will be a long way to go in the construction of telemedicine in China.
Association of AI-determined Kellgren–Lawrence grade with medial meniscus extrusion and cartilage thickness by AI-based 3D MRI analysis in early knee osteoarthritis
Authors: Sekiya Ichiro , Katano Hisako , Guermazi Ali , Miura Yugo , Okanouchi Noriya , Tomita Makoto , Masumoto Jun , Kitazume Yoshio , Koga Hideyuki , Ozeki Nobutake 
Published: November 2023

AbstractThe associations among Kellgren–Lawrence (KL) grade, medial meniscus extrusion (MME), and cartilage thickness in knee osteoarthritis (OA) remain insufficiently understood. Our aim was to determine these associations in early to moderate medial tibiofemoral knee OA. We included 469 subjects with no lateral OA from the Kanagawa Knee Study. KL grade was assessed using artificial intelligence (AI) software. The MME was measured by MRI, and the cartilage thickness was evaluated in 18 subregions of the medial femorotibial joint by another AI system. The median MME width was 1.4 mm in KL0, 1.5 mm in KL1, 2.4 mm in KL2, and 6.0 mm in KL3. Cartilage thinning in the medial femur occurred in the anterior central subregion in KL1, expanded inwardly in KL2, and further expanded in KL3. Cartilage thinning in the medial tibia occurred in the anterior and middle external subregions in KL1, expanded into the anterior and middle central subregions in KL2, and further expanded in KL3. The absolute correlation coefficient between MME width and cartilage thickness increased as the KL grade increased in some subregions. This study provides novel insights into the early stages of knee OA and potentially has implications for the development of early intervention strategies.
Geochronological results from the Zhela Formation volcanics of the Tethyan Himalaya and their implications for the breakup of eastern Gondwana
Authors: Liang Jiacheng , Bian Weiwei , Jiao Xianwei , Peng Wenxiao , Ma Jiahui , Wang Suo , Ma Yiming , Zhang Shihong , Wu Huaichun , Li Haiyan , Shi Yuruo , Yang Tianshui 
Published: November 2023

AbstractThe relationship between the Kerguelen mantle plume and the breakup of eastern Gondwana is still debated. The new Zircon SHRIMP U–Pb dating of 139.9 ± 4.6 Ma, as well as previous ages from the Zhela Formation volcanic rocks in the Tethyan Himalaya, show that the studied Zhela Formation volcanic rocks formed during the Late Jurassic-Early Cretaceous, rather than the Middle Jurassic. The calculated volume of the Comei-Bunbury igneous rocks is ~ 114,250 km3, which is compatible with the large igneous provinces and, consequently, the typical mantle plume models. The new date results, along with existing dates, show that the volcanism attributed to the Kerguelen mantle plume in the Tethyan Himalaya ranges from ca.147 Ma to ca.124 Ma, with two peaks at approximately 141 Ma and 133 Ma. This new finding, together with geochemical and palaeomagnetic data obtained from the Comei-Bunbury igneous rocks, indicate that the Kerguelen mantle plume contributed significantly to the breakup of eastern Gondwana and that eastern Gondwana first disintegrated and dispersed at ca.147 Ma, the Indian plate separated completely from the eastern Gondwana before ca.125 Ma.
Classification of SLC family-related genes involved in ferroptosis predicts lung cancer prognosis and immunotherapy response
Authors: Gao Shun , Gong Guotao , Wang Xinyi , Gao Xinrui , Guo Xuanzhu , Luo Yuyao , Li Sijie , Zhang Yan , Lin Sheng 
Published: November 2023

AbstractLung adenocarcinoma, the most frequent type of lung cancer, is the leading cause of cancer-related deaths worldwide. Ferroptosis, controlled cell death that involves a high degree of iron-dependent lipid peroxidation, has been linked to tumor therapy sensitivity, patient prognosis, and cancer development. The solute carrier superfamily has over 400 members and comprises the largest class of transporters in the human genome. Solute carrier proteins can facilitate the movement of different substrates across biological membranes, which is crucial for physiological activities, including ferroptosis. Here, we developed a new model to further explore the role of the solute carrier family in ferroptosis in the lung adenocarcinoma immunological milieu. We used consensus clustering to classify patients with lung cancer into two subgroups (cluster1 and cluster2). Patients in the cluster1 subtype had a better prognosis and higher immune cell infiltration ratios than those in the cluster2 subtype. Furthermore, to evaluate the prognosis, the immune cell infiltration ratio, and the medication sensitivity of patients with lung adenocarcinoma, we developed gene scores related to the solute carrier family. In conclusion, we successfully developed a model incorporating the solute carrier family and ferroptosis to predict survival and the impact of immunotherapy on patients with lung cancer.
Cytokine profile and viral diversity in the early seronegative stage of community-acquired hepatitis C virus (HCV) infection
Authors: Radkowski Marek , Grabarczyk Piotr , Kryczka Tomasz , Caraballo Cortès Kamila , Kubicka-Russel Dorota , Janiak Maciej , Osuch Sylwia , Perlejewski Karol , Laskus Tomasz 
Published: November 2023

AbstractMost Hepatitis C virus (HCV)-infected subjects develop chronic infection, whereas a minority clear the virus in the early phase of infection. We analyzed factors associated with outcome (chronicity vs clearance) during the preclinical seronegative phase of community-acquired HCV infection. Among 17.5 million blood donations in the years 2000–2016, 124 blood donors were found to be HCV RNA-positive/anti-HCV-negative. All were contacted after 0.5–12.7 years and 40 responded and provided blood sample. Hypervariable region 1 was analyzed by ultradeep pyrosequencing and cytokines in serum were quantified by Luminex (R&D Systems) multiplex immunoassay. Twenty-one (52.5%) donors were found to be HCV-RNA-positive, while 19 (47.5%) were HCV RNA negative (none received antiviral treatment). All but one seroconverted to anti-HCV. Donors with resolving hepatitis did not differ significantly from donors with chronic infection with respect to age, genotypes, IL28B polymorphisms, number of viral variants, nucleotide diversity per site or the overall number of nucleotide substitutions. However, the former group had significantly higher levels of IL-1beta, IL-1RA, IL-6, IFN-gamma and FGF-2 in serum. In our study of community-acquired acute hepatitis C approximately half of all subjects eliminated the virus spontaneously, and this clearance was associated with marked cytokine response in the early seronegative stage of infection.
A modelling study of hole transport in GaN/AlGaN superlattices
Authors: Bai Mengxun , Rorison Judy 
Published: November 2023

AbstractThe transport of holes through p-doped wurtzite bulk GaN and AlGaN is poor so transport of holes through GaN/AlGaN superlattices has been proposed and investigated theoretically and experimentally with experimental results showing poor transport. The reason for this poor performance is not fully understood. In this paper, the transport of holes in GaN/AlGaN wurtzite crystal superlattices is investigated through theoretical modelling, examining the role of the composition of the Al$$_x$$

x

Ga$$_{1-x}$$

1
-
x

N barrier regions and the thickness of the GaN quantum wells and the AlGaN barriers in determining the position and width of the heavy hole miniband. To consider the transport of the holes in the miniband we examine the effective mass of the miniband and possible scattering mechanisms. In particular, ionized impurity (II) scattering from ionized acceptors in the barrier regions is investigated as it is deemed to be the dominating scattering mechanism degrading hole transport. The energy position of the miniband relative to the ionized impurities and the wavefunction overlap with the ionized acceptors in the barrier regions is investigated to minimize II scattering. Some designs to optimize hole transport through wurtzite p-doped GaN/AlGaN superlattices to minimize II scattering are proposed.
Preliminary Speech Perception Performance Profiles of School-Age Children With Childhood Apraxia of Speech, Speech Sound Disorder, and Typical Development
Authors: Hitchcock Elaine R. , Swartz Michelle T. , Cabbage Kathryn L. 
Published: November 2023

Purpose:
Limited research exists assessing speech perception in school-age children with speech sound disorder (SSD) and childhood apraxia of speech (CAS); despite early evidence that speech perception may lead to error-prone motor planning/programming. In this study, we examine speech perception performance in school-age children with and without speech production deficits.

Method:
Speech perception was assessed using the Wide Range Acoustic Accuracy Scale to determine the just-noticeable difference in discrimination for three consonant–vowel syllable contrasts (/bɑ/−/wɑ/, /dɑ/−/gɑ/, /ɹɑ/−/wɑ/), each varying along a single acoustic parameter for seven children with CAS with rhotic errors, seven children with SSD with rhotic errors, and seven typically developing (TD) children.

Results:
Findings revealed statistically significant mean differences between perceptual performance of children with CAS when compared to TD children for discrimination of /ɹɑ/−/wɑ/ contrasts. Large effect sizes were also observed for comparisons of /ɹɑ/−/wɑ/ contrasts between children with CAS, SSD, and TD peers. Additionally, large effect sizes were observed for /dɑ/−/gɑ/ contrasts between children with CAS and SSD and TD children despite nonsignificant mean differences in group performance.

Conclusions:
Overall, mean outcome scores suggest that school-age children with CAS and persistent rhotic errors demonstrated less accurate speech perception skills relative to TD children for the /ɹɑ/−/wɑ/ contrasts. However, the relatively small sample sizes per group limit the extent to which these findings may be generalized to the broader population.
Remote Voice Therapy With an Oscillatory Positive Expiratory Pressure Device in Subjects With Vocal Fatigue: A Randomized Controlled Trial
Authors: Acevedo Karol , Guzman Marco , Ortega Andrés , Aguirre Camila , Diaz Sofía , Escudero Javiera , Quezada Camilo 
Published: November 2023

Purpose:
The present study aimed at assessing the efficacy of remote voice therapy (telepractice) implemented with Shaker Medic Plus device in subjects with vocal fatigue.

Method:

Thirty-six participants were initially enrolled in this study. Twenty-four participants with vocal fatigue were finally randomly assigned to one of two treatment groups: (a) voice treatment with Shaker Medic Plus device plus vocal hygiene program (
n
= 12) and (b) voice treatment with water resistance therapy (WRT) plus vocal hygiene program (
n
= 12). Laryngoscopic assessment was conducted on all subjects. Before and after voice therapy, participants underwent (a) self-assessment of voice: Vocal Fatigue Index and Vocal Tract Discomfort Scale and (b) instrumental assessment with aerodynamic, acoustic, and electroglottographic measures. The treatment period included six voice therapy sessions within 6 weeks. Each session lasted 30 min. For both groups, exercises consisted of a sequence of nine phonatory tasks performed with Shaker Medic Plus (experimental group) and WRT (control group). Comparisons for all variables were performed between the experimental group and control group.

Results:
Significant improvements were found for self-reported variables when comparing pre- and postmeasures for both groups. No significant differences were found when comparing groups. No significant main effects or interactions were observed for any of the observed instrumental variables.

Conclusions:
Remote physiologic voice therapy with Shaker Medic Plus device and water resistance therapy seem to be both effective to improve voice in subjects diagnosed with vocal fatigue. No differences should be expected between these therapeutic protocols when treating patients with vocal fatigue. Moreover, both are effective at reducing tiredness of voice, voice avoidance, physical discomfort associated with voicing, subjective perception of sensory discomfort in throat, and reduction of physical, emotional, and functional impact of voice problems.
Image preprocessing‐based ensemble deep learning classification of diabetic retinopathy
Authors: Macsik Peter , Pavlovicova Jarmila , Kajan Slavomir , Goga Jozef , Kurilova Veronika 
Published: November 2023

AbstractDiabetic retinopathy (DR) can cause irreversible eye damage, even blindness. The prognosis improves with early diagnosis. According to the International Classification of Diabetic Retinopathy Severity Scale (ICDRSS), DR has five stages. Modern, cost‐effective techniques for automatic DR screening and staging of fundus images are based on deep learning (DL). To obtain higher classification accuracy, the combination of several diverse individual DL models into one ensemble could be used. A new approach to model diversity in an ensemble is proposed by manipulating the training input data involving original and four variants of preprocessed image datasets. There are publicly available datasets with labels for all five stages, but some contain poor‐quality images. In contrast, this algorithm was trained on images from a six‐class DDR dataset, including the class of poor‐quality ungradable images, to enhance the classification performance. The solution was evaluated on the APTOS dataset, containing only ICDRSS classes. Classification results of the ensemble model were presented on two different ensemble convolutional neural network (CNN) models, based on Xception and EfficientNetB4 architectures using two fusion approaches. Our proposed ensemble models outperformed all other single deep learning architectures regarding overall accuracy and Cohen's Kappa, with the best results using the EfficientNetB4 architecture.
Stadtgrün und Stadtblau im Klimawandel
Authors: Kistemann Thomas , Zerbe Stefan , Säumel Ina , Fehr Rainer 
Published: November 2023

ZusammenfassungUm die urbanen Gesundheitsrisiken des Klimawandels nachhaltig zu reduzieren und
zu managen, sind Klimaschutz und Klimaanpassung als komplementäre
Strategien dringend erforderlich. Seit Jahrzehnten sind vielfältige
positive Wirkungen von Stadtgrün und Stadtblau auf die physische und die
mentale Gesundheit bekannt. Allerdings gibt es in den meisten Städten
eine intensive Konkurrenz um die Nutzung von Flächen. Im Sinne der
europäischen Aalborg-Charta von 1994 verlangt das deutsche Baurecht in
diesem anspruchsvollen Kontext, dass Bauleitpläne eine nachhaltige
städtebauliche Entwicklung gewährleisten sollen. Die menschliche
Gesundheit ist dabei ein Belang von zentraler Bedeutung. Die Realität
bleibt aber herausfordernd: Zwar gibt es inzwischen eine ganze Reihe von best
practice-Beispielen. Nach wie vor besteht aber ein großer
Forschungsbedarf zur Bedeutung urbaner Grün- und Blauräume
für die menschliche Gesundheit und das gesundheitliche Wohlbefinden.
Zudem müssen alle relevanten Politikfelder und Verwaltungseinheiten ein
Bewusstsein für die Bedeutung von Grün und Blau für
urbane Lebensqualität und Gesundheit entwickeln, um
„Gesundheit“ in städtischen Entscheidungsprozessen
adäquat und sozial sensibel zu berücksichtigen.
Stadtepidemiologie als integrativer Ansatz für eine
nachhaltige, gesundheitsfördernde Stadtentwicklung
Authors: Bolte Gabriele , Moebus Susanne , Fehr Rainer 
Published: November 2023

ZusammenfassungDas Verständnis komplexer Zusammenhänge zwischen physischer und
sozialer Lebensumwelt und Gesundheit im urbanen Raum ist essentiell für
die Entwicklung geeigneter Maßnahmen der Gesundheitsförderung,
Prävention und des Gesundheitsschutzes. Dieser Beitrag hat zum Ziel, den
vergleichsweise neuen Ansatz der Stadtepidemiologie mit ihrer Bedeutung
für das Forschungs- und Praxisfeld urbane
Gesundheit/StadtGesundheit zu charakterisieren. Forschung im Bereich
Stadtepidemiologie bietet wichtige Daten- und Methodengrundlagen für
eine integrierte Berichterstattung, für
Gesundheitsfolgenabschätzungen sowie für Evaluation von
Maßnahmen. Es werden aktuelle Herausforderungen und
Lösungsansätze skizziert und erste Empfehlungen für
Forschung, Praxis sowie Aus- und Fortbildung zur Diskussion gestellt. Methoden
und Erkenntnisse der Stadtepidemiologie können auf vielfältige
Weise zu einer gesundheitsfördernden, nachhaltigen Stadtentwicklung
beitragen.
Stereodivergent Synthesis of rac-cis- and rac-trans-4-Hydroxyphosphopipecolic Acids
Authors: Ordóñez Mario , Morales-Solís Juan Carlos , Argüello-Velasco Rubén Oswaldo , Viveros-Ceballos José Luis , Labastida-Galván Victoria 
Published: November 2023

AbstractWe report herein the first stereodivergent synthesis of rac-cis- and rac-trans-4-hydroxyphosphopipecolic acids. The main feature of this methodology is the controlled cis or trans reduction of 4-oxophosphopipecolates by exclusively varying the size of the hydride reagents. Thus, a small hydride reagent (NaBH4) adds selectively from the axial side of the carbonyl group to give the equatorial hydroxyl group (cis-product), whereas a bulky hydride reagent such as LiBH(sec-Bu)3 (L-Selectride®) preferentially attacks from the equatorial side, giving the hydroxyl group in the axial position (trans-product). In the last step, hydrolysis of the diethyl phosphonate and ethyl phenylphosphinate groups with bromotrimethylsilane, followed by methanolysis, led to the target compounds.
Outcomes after Conversion from Video-Assisted Thoracoscopic Lobectomy to Thoracotomy
Authors: Taylor Marcus , Raj Krishna Gokul , Rammohan Kandadai , Fontaine Eustace , Joshi Vijay , Grant Stuart , Granato Felice 
Published: November 2023

Abstract
Background Lung cancer resections are increasingly being performed via video-assisted thoracoscopic surgery (VATS). Conversion to thoracotomy can occur for many reasons and may affect outcomes. The objective of this study was to investigate the impact of VATS conversion on short- and mid-term outcomes and identify reasons for conversion.
Methods Consecutive patients undergoing lobectomy for primary non-small cell lung cancer between 2012 and 2019 in a single UK center were included. Primary outcomes were 90-day mortality, intraoperative conversion, and overall survival. Reasons for conversion were defined as bleeding or nonbleeding. Outcomes were compared between groups using univariable analysis. Multivariable logistic regression analysis was performed to identify risk factors for conversion.
Results A total of 2,622 patients were included with 20.6% (n = 541) completing surgery via VATS and 79.4% (n = 2,081) via thoracotomy. The rate of completed VATS surgery increased significantly over time (2012: 6.9%, 2019: 55.1%, p < 0.001). Overall conversion rate was 14.3% (n = 90/631) and has reduced significantly over time (p < 0.001). The rate of conversion due to intraoperative bleeding was 31.1% (n = 28/90). Obesity, male sex, and stage III disease were independent risk factors for conversion. The 90-day mortality rate after conversion was not significantly different from the rate for planned thoracotomy (3.3 vs. 3.4%, p = 0.987). There was no significant difference in overall survival between patients experiencing intraoperative conversion and those undergoing planned thoracotomy (p = 0.135).
Conclusion This study demonstrates comparable outcomes for patients undergoing conversion from VATS to those undergoing planned surgery via thoracotomy. It remains unclear if reason for conversion is associated with outcomes.