bluuebunny/crossref_metadata_2025_split huggingface dataset:
El impacto del humano en el planeta
Authors: Montes de Oca García Lizeth 
Published: January 2024

Mucho se especula del afamado día cero. Aquel, en el que el agua de este planeta será la causa de una batalla humana, la cual dejará como cicatriz la ausencia de millones de especies en el mundo, el agotamiento de recursos naturales, e inclusive, el cobro de millones de vidas. El déficit hídrico que está aquejando este año al país y el mundo, llama mucho la atención. La pregunta es simple: ¿Qué le está pasando al mundo? Y a pregunta simple hay respuesta simple, el cobro de factura de nuestra huella ecológica. ¿has escuchado hablar de la huella ecológica? ¿Cuánta agua usas en un día normal? ¿Qué alimentos consumes y en qué cantidad? ¿Cuál es tu medio de transporte más recurrente? ¿Cómo haces uso de la tecnología? Considerando la modernidad y el gran rango de necesidades humanas que tenemos que solventar, todas las respuestas oscilan en que el ser humano es quien más necesita del planeta, para existir. Sin embargo, debería ser imperante que el ser humano regrese el favor al planeta, pero la falta de concientización, el uso excesivo de recursos no renovables y también de los renovables, así como la deficiencia burocrática, están debilitando poco a poco a nuestro ecosistema. Este articulo presenta de manera breve como visualizar nuestra huella ecológica y a su vez otros términos que acechan el agotamiento de nuestro planeta, ese impacto que como humanidad nos está llevando a buscar vida en otros planetas.
La educación a distancia
Authors: Hernández López Luz Monserrat 
Published: January 2024

La educación a distancia es un sistema tecnológico de comunicación bidireccional (multidireccional) que puede ser masivo García Aretio basado en la acción sistemática y conjunta de recursos didácticos que propician un aprendizaje independiente. (García Aretio, 2002)
Su evolución se toma en cuenta la teología, el uso de documentos impresos que eran distribuidos mediante el servicio de correo, el uso de medios electrónicos y el uso de módulos y el correo, pero se incorporó la radio y la televisión.
Una breve descripción sobre Arduino
Authors: Santana Tavera Karina 
Published: January 2024

Arduino es una plataforma de hardware basada en un microcontrolador ATMEL la cual permite desarrollar múltiples proyectos, creada por David Cuartielles, Gianluca Martino, Tom Igoe, David Mellis y Massimo Banzi en 2005 en el Instituto de Diseño Interactivo (IVREA) en Italia.
Dentro del ámbito educativo juega un papel importante al fortalecer el pensamiento computacional en estudiantes de nivel medio superior ejercitando también sus capacidades cognitivas y toma de decisiones.
Síndrome de burnout en personal de enfermería tras la atención de pacientes con COVID-19 en un hospital de tercer nivel en la Ciudad de México
Authors: Hernández Mariano Jose Angel , Razo-Blanco-Hernández Dulce Milagros , Ricardez-Romero María Antonia , Sarmiento-Cortes Pauló 
Published: January 2024

Introducción: Evidencia previa, sugiere que el síndrome de burnout puede seguir manifestándose tiempo después de que los factores estresantes en el ambiente laboral se hayan disminuido, por lo que el personal de enfermería que en el algún momento brindó cuidado asistencial a pacientes críticos con COVID-19 podría seguir presentando esta condición. Objetivo: Determinar la frecuencia de SB en el personal de enfermería posterior a la atención de pacientes con COVID-19. Métodos. Estudio cuantitativo transversal realizado en una muestra de 133 enfermeros de un hospital de tercer nivel de la Ciudad de México, México. Para determinar la presencia de SB se empleó el Inventario de Burnout de Maslach conformado por las dimensiones: agotamiento, despersonalización y baja realización personal. Resultados: El 88,0% del personal de enfermería presentó SB general. El 6% de los participantes tuvo niveles altos de SB en la dimensión de desgaste emocional; mientras que el 38,8% y el 88,8% presentaron estos mismos niveles en las dimensiones de despersonalización y realización personal. La frecuencia de SB en la dimensión de despersonalización fue más alta en aquellos que desempeñaban en el área de urgencias. Conclusiones: La frecuencia de SB en el personal de enfermería que en algún momento participó de manera activa en la atención de pacientes con COVID-19 es alta. Dadas las repercusiones que dicha condición puede tener en la salud del personal de enfermería, así como en la calidad de la atención a los pacientes, es imperante el desarrollo de protocolos de actuación psicológica dirigida al personal de enfermería.
Gıda Kaynaklı Botulizme Bağlı Solunum Yetmezliği: Nadir Bir Olgu
Authors: ARDA Umut , OSOYDAN SATICI Merve , ÖZDEMİR Serdar , EROĞLU Serkan Emre 
Published: January 2024

Botulizm, Clostridium botulinum türlerine ait nörotoksinin neden olduğu hayatı tehdit eden ve nadir
görülen bir presinaptik nöromüsküler kavşak bozukluğudur. Botulizme neden olan ve botulinum toksini
olarak bilinen bu toksin en kuvvetli ekzotoksindir. Gıda kaynaklı botulizm en yaygın görülen form olup,
önceden oluşmuş toksin ile kontamine gıdaların tüketilmesi ile meydana gelir. Bu durum klinik şiddeti
nedeniyle tıbbi bir acil durumdur ve dünya genelinde birçok ülkede salgınlar bildirilmiştir.
Kırk iki yaşında hasta nefes darlığıyla başvurup hızlı solunum yetmezliğine ilerledi. Solunum yetmezliği
nedeniyle mekanik ventilasyon uygulandı. Elektronöromiyografik olarak botulizm tanısı doğrulandı.
Mekanik ventilatör desteği ve antitoksin uygulanan hasta tam iyileşme ile taburcu edildi.
Botulizm bir toksidrom olmasına rağmen akut nörolojik semptomların ve özellikle yaşamı tehdit eden
akut solunum yetmezliğinin ayırıcı tanısında mutlaka düşünülmesi gerekmektedir
Dikkat Eksikliği ve Hiperaktivite Bozukluğu Olan Çocuklarda Metilfenidat’ın Düzeltilmiş QT Mesafesi Üzerine Etkisi: Bir Üniversite Hastanesi Örneği
Authors: TUNÇER Tunç , HACIİBRAHİMOĞLU Esra , DOĞAN Samet , TAŞKIN Gaye , YETİŞKUL Eylül İlayda , SEÇKİN Berke Bora , TÜRKKAN Ali Sinan , ASLAN Ömer Faruk 
Published: January 2024

Amaç: Bu çalışma dikkat eksikliği ve hiperaktivite bozukluğu nedeni ile metilfenidat kullanımının
elektrokardiyografide düzeltilmiş QT mesafesine etkilerinin incelenmesi amacıyla yapılmıştır.
Gereç ve Yöntemler: Çalışma Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Pediatrik kardiyoloji
polikliniğinde Nisan 2023 - Haziran 2023 tarihleri arasında yapılmıştır. Dikkat eksikliği ve hiperaktivite
bozukluğu tanısı ile başvurup anemnez, fizik muayene ve elektrokardiyografi değerlendirmesi sonrası
başka bir tanı almayan 6-18 yaşlarında 30 çocuk çalışmaya dâhil edildi. Hastalar 15 gün metilfenidat
kullandıktan sonra poliklinikte tekrar değerlendirilip yeniden elektrokardiyografileri çekildi. Ardışık
elektrokardiyografilerde düzeltilmiş QT mesafesi süreleri 60 milisaniyeden daha fazla artış saptanması
ya da düzeltilmiş QT mesafesinin 500 milisaniyeden veya daha fazlasına erişmesi durumunda
metilfenidatın QT mesafesini uzattığı kanaatine varıldı. QTc değerleri arasındaki farkı değerlendirmek
için Wilcoxon testi kullanıldı
Bulgular: Çalışmada 20 erkek (%66,6) ve 10 kız (%33,3) hasta mevcuttu. Ortalama yaş 10 ± 3.3 olarak
saptandı. Hastalarda metilfenidat tedavisi öncesi ve sonrasında anemnezlerinde şikâyet saptanmadı ve
fiziki muayeneleri normal bulundu. Hastaların metilfenidat başlanmadan önce çekilen elektrokardiyografilerinde
ortanca QTc değeri 410 ms (minimum: 360, maksimum: 442 ms) olarak tespit edildi. Tedavi
sonrası elektrokardiyografilerde tedavi öncesine göre QT mesafesinin uzamadığı saptandı ve istatistiksel
olarak anlamlı bir fark bulunmadı (p=0.202).
Sonuç: Çocuklarda dikkat eksikliği ve hiperaktivite bozukluğu tedavisinde metilfenidat kullanımı
kardiyak aritmi gelişimi açısından güvenli gözükmektedir ancak hastaların ilaca başlanmadan önce
elektrokardiyografilerinin değerlendirilmesi ve tedavi sonrası daha erken (özellikle ilk üç günde) tekrar
değerlendirilme yapılması uygun olacaktır.
Association of Hypervitaminosis D with Thyroid Function in Euthyroid Adult Patients
Authors: TOPALOĞLU Ömercan , MÜDERRİSOĞLU Şeyma Büşra 
Published: January 2024

Aim: No study has investigated the effect of hypervitaminosis D on thyroid function. We aimed to analyze
possible associations of hypervitaminosis D with thyroid function in levothyroxine-naive euthyroid
patients.
Material and Methods: Levothyroxine-naive euthyroid patients (>18-year-old) with 25(OH) vitamin D
level of ≥88 ng/mL after supplementation were analyzed retrospectively. We grouped them as: Group 1,
TSH increased above the range; Group 2, TSH increased but in normal range; Group 3, TSH decreased
but in normal range; Group 4, TSH decreased below the range; Group A, TSH increased; and Group
B, TSH decreased. Before/after levels of TSH, fT4, Ca, P, creatinine, and TSH-change, fT4-change,
25(OH) vitamin D (basal/post-treatment and change), basal AntiTPO levels, and vitamin D dose were
analyzed.
Results: TSH-change -0.19±1.03 mIU/L and fT4-change 0.015±0.17 ng/dL were insignificant in
total(n=64). Post-treatment 25(OH) vitamin D, TSH-after, and TSH-change were higher in group 1(n=3)
than in group 2(n=22), group 3(n=33), or group 4(n=6) (p
The Effect of Washing After Protein Blocking on Immunohistochemical Staining Applied to Paraffin Sections
Authors: KEÇECİ Mete , KOCA Elif , ARSLAN Esra , DENEK Reyyan Başak , SARI Ezgi Su , AKPINAR İpek Pınar , ÜLKER Bünyamin , ATICI Kağan , ERBAKAN Özgenur , CENGİL Osman 
Published: January 2024

Aim: Immunohistochemistry is still frequently preferred in both diagnostic and experimental studies
because it can show proteins where they are in the tissue. One of the main problems in immunohistochemistry
is the background staining, which can be prevented by protein blocking and which occurs as
a result of binding of primary antibodies to tissue proteins and Fc receptors in the tissue due to antigenic
similarity. There is no consensus on whether to wash after protein blocking in current publications and
immunohistochemistry manuals published by manufacturers.
Material and Methods: In our study, routine immunohistochemistry procedure was applied to determine
the expression of TNF-α on 5 μm thick sections obtained from rat gastric tissue samples in which an
experimental gastric ulcer model was created with ethanol, and two groups were formed, with and without
washing after protein blocking, with 10 sections in each group. For semi-quantitative evaluation, the
histological score (h-score) was calculated from the images obtained from the immunohistochemically
stained preparations of both groups and the obtained data were statistically compared.
Results: As a result of our study, no statistically significant difference was found between the h-score
values of the groups that were washed after protein blocking in immunohistochemical staining and
the groups that did not wash (p=0.971). The median (min-max) values of the groups with and without
washing are 211 (179-244) and 215 (171-251), respectively.
Conclusion: In the immunohistochemical staining procedure, washing after protein blocking does not
change the staining intensity, does not create background staining, and does not affect the result of
the h-score for semiquantitative evaluation. Similar studies are recommended for other species, tissue
types and antigens.
Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi 2022-2023 Eğitim ve Öğretim Yılı Dönem 3 Öğrencileri Kanıta Dayalı Tıp Proje Özetleri
Authors: TURAN İnci , KEÇECİ Mete , DALGIÇ Ertuğrul , AYDEMİR Hande , BAYRAKTAROĞLU Taner , CAN Murat 
Published: January 2024

Amaç: Kanıta dayalı tıp (KDT) uygulamaları, Tıp Fakültesi öğrencilerinin tıbbi araştırmaların
tasarlanması, yürütülmesi, bulguların analizi ve sunumu alanlarında tecrübe kazanmalarını amaçlar. Bu
sayede eleştirel düşünme ve bilimsel akıl yürütme yeteneği kazanmış hekimlerin sağlık ve akademik
camiaya kazandırılmasını hedefler.
Gereç ve Yöntemler: KDT dersi, Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Dönem III ders
programı içinde yer almaktadır. Öğrencilerin bilimsel araştırma sürecinde bir danışman öğretim üyesi
rehberliğinde çalışmaları sağlanır. Fakültenin Eğitim komisyon başkanı bütün çalışmalara önderlik
eder. Bu kapsamda KDT çalışmaları, bir dönem boyunca ders programında belirlenen tarihlerde
gruplar halinde bir araya gelinerek, araştırma konusunun belirlenmesi ve planlanması, etik kurulu onay
sürecinin gerçekleştirilmesi, araştırma verilerinin incelenmesi ve projenin sunulması şeklinde yürütülür.
Bulgular: 2022-2023 Eğitim döneminde gerçekleştirilen KDT çalışmalarına Dönem III’ten 81 öğrenci
ve danışman 14 öğretim üyesi katıldı. Öğrencilerin ve hastaların katılımıyla yapılan anket çalışmaları,
klinik çalışmalar, ve temel tıp bilimleri alanındaki laboratuvar çalışmaları bu eğitim yılındaki KDT proje
konularını oluşturdu. Projelerin sonuçları öğretim üyelerinin rehberliğinde öğrenciler tarafından çevrimiçi
ortamda sunuldu.
Sonuç: KDT dersi, Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesinin mezuniyet öncesi eğitim
müfredatının önemli bir parçasıdır. Daha önceki yıllarda olduğu gibi, 2022-2023 Eğitim döneminde
de, projeler başarıyla yürütülmüş ve öğrencilerin bilimsel düşünme ve analiz metodolojisinde tecrübe
kazanmaları sağlanmıştır.
Navigating Stigma and Discrimination: Betrothal Challenges Faced by Descendants of Leprosy in Madura, Indonesia
Authors: Sabri Fahruddin Ali , Rosyadi Imron , Isfironi Mohammad , Hadi Mukhammad Nur , Sulthon M , Khazin A. Mufti 
Published: January 2024

This article aims to uncover stereotypes against lepers and their descendants by impacting difficulties in finding a potential partner and the risk of being abandoned by a potential partner. This clearly cannot be underestimated and is part of the State and non-state actors’ responsibilities in protecting human rights based on Islamic law. This article used ethnography as a methodology of research when dialogue and observation were used as research techniques. This study’s findings revealed that the descendants of lepers were considered a threat to the survival of their descendants, so they got discriminatory treatment, exclusion, stigmatization, exile, and inequality which in turn could interfere with their dignity. The Dhohiri School had a different view out of the four Schools of Islamic law namely Hanafi, Maliki, Shafi'i, and Hanbali, where this School rejected divorce because of disability in any form. Dhohiri School had shown partiality and respect for the human rights of lepers and their descendants to engage in Betrothal and marriage without any discrimination, exclusion, stigmatization, banishment, or inequality of any kind. The alignment of the Dhohiri School is in line with the State and non-state actors’ efforts to minimize the inhumane and terrible treatments of people with leprosy and their descendants.
The Effect of Using Storytelling Method By Video Towards Students’ Speaking Skill at The Eighth Grade Students of MTs An-Nur Kemayoran Central Jakarta in Academic Year 2021/2022
Authors: Mutmainnah Fitri Nur , Gumelar Rizdki Elang , Munawaroh Tatu 
Published: January 2024

The purpose of the study is to determine the effect of using storytelling method to improve students' speaking skill. Storytelling as the entire context of a moment when oral narration of stories in verse or in prose, is performed or led by one person before a live audience. The scope of this research focuses on analyzing the effect of using storytelling method by video toward students’ speaking skill. This research took quantitative approach, while the method used experimental with pre-test and post-test experimental class and control class design. The instrument used was achievement test. The subjects of this study were selected using random sampling. The results of the analysis of the pre- test and post-test experiments using the storytelling method showed an Sig (2-tailed) of 0.00 from the decision that if Sig (2-tailed) < 0.05 then the data was significant, meaning that the hypothesis was accepted. And if the result of Asymp Sig (2-Tailed) > 0.05 then the hypothesis is rejected. On the other word, there is any significant effect of Storytelling towards Students’ Speaking Skill.
Rebranding Keripik Pelepah Pisang Produk UP2K PKK Desa Kukuh Kerambitan Tabanan
Authors: Julianto I Nyoman Larry , Mudra I Wayan , Suparthana I Putu , Adnyana I Nyoman Widhi , Andreani Ni Putu Elvian 
Published: January 2024

Tujuan kegiatan pengabdian adalah pengembangan peningkatan kualitas desain kemasan dan strategi pemasaran keripik pelepah pisang kelompok Usaha Peningkatan Pendapatan Keluarga (UP2K) PKK Desa Kukuh Kerambitan. Kegiatan pengabdian dilaksanakan menggunakan dua tahap yaitu tahap Focus Group Discussion (FGD) untuk penentuan nama produk beserta elemen visual produk dan workshop strategi pemasaran digital melalui pembuatan desain poster digital. Hasil FGD menyepakati nama ‘DèBong’ sebagai identitas produk keripik yang cenderung mampu mewakili bahan bakunya, yakni pelepah pisang atau gedebong. Referensi terkait Ilustrasi dan warna yang disepakati adalah berdasarkan warna alami pada pelepah pisangnya serta unsur lainnya pada pohon pisang, seperti daun dan buahnya. Kegiatan PKM mendapatkan apresiasi yang sangat baik dari Ketua Tim Penggerak Pemberdayaan dan Kesejahteraan Keluarga (TP–PKK) dan Kepala Desa Kukuh Kerambitan. Capaian kegiatan yang dilaksanakan mencapai di angka 120%, yakni pada tingkat pengetahuan dan keterampilan peserta pendampingan dalam memahami dan mengkonsepkan desain kemasan serta strategi promosi melalui media sosial menjadi lebih meningkat.
Pengembangan Ekonomi Kreatif Berbasis Kearifan Lokal Menuju Pariwisata Berkelanjutan
Authors: Haisah S. , Ariawan Ariawan , Abdussamad Cahya Pradipta 
Published: January 2024

Untuk mencapai konsep pariwisata berkelanjutan diperlukan upaya dan dukungan dari sektor lain untuk menciptakan nilai tambah yang mampu mendorong pertumbuhan ekonomi. Ekowisata pinus motilango dalam pengembangannya memiliki permasalahan manajemen, produksi dan pemasaran. Pengabdian ini bertujuan untuk meningkatkan pengetahuan tentang menggali potensi wisata dan manajemen usaha, peningkatan keterampilan memproduksi kerajinan serta pengetahuan strategi pemasaran. Metode yang digunakan yaitu pelatihan, praktek dan pendampingan. Hasil pengabdian kemitraan masyarakat menghasilkan peningkatan pengetahuan menggali potensi wisata dan usaha sebesar 93%, manajemen usaha sebesar 90%, strategi pemasaran 85%. Sedangkan peningkatan keterampilan berupa terbentuknya unit usaha baru, terlaksananya festival gambusi dan festival tari tradisional serta terwujudnya strategi pemasaran produk kerajinan khas menggunakan konsep visual di media online.
Prodrug Approach: NSAID Conjugates of Platinum Compounds as Anti-Cancer Agents
Authors: B NIJA 
Published: January 2024

Prodrug based synthetic approach is a very promising area of research to enhance the pharmaco–kinetic and pharmaco-dynamic properties of the drugs with the remarkable reduction of the side effects. Prodrug can be used for drugs which are having poor solubility, poor transport properties, production of chronic side effects thus this approach provides a powerful tool for novel drug conjugate with improved therapeutic value. Platinum based anti-neoplastic agents are widely used in chemotherapeutic regimen but the side effects like hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting, diarrhea, mucositis, stomatitis, pain, alopecia, anorexia, cachexia, cytopenias and asthenia were reported. So the development of prodrugs by using platinum compounds and Non-steroidal anti-inflammatory drugs showed better therapeutic value with the reduction of side effects. Non-steroidal anti-inflammatory drugs are broad class of drugs showed Analgesic, Anti–inflammatory and Anti-pyretic activities based on the mechanism of cyclooxygenase (cox-1 and cox-2) enzyme inhibition and formation of prostaglandins. Also Non-steroidal anti-inflammatory drugs have different targets to elicit various pharmacological actions and are beneficial for many other diseases. The different targets are nuclear factor kappa B(NF-Κb), Peroxisome proliferator-activated receptors(PPAR), Mammalian target of rapamycin(mTOR), Autophagy, Cytochrome c, NSAID activated gene (NAG-1), Angiogenesis, Resolvins, Protectins, Maresins. This review focused on the development of platinum prodrugs by conjugating with different NSAIDs and the therapeutic applications of the developed novel molecules including dual action and triple action prodrugs. This review discussed the different aspects of prodrug based approach, Detail mechanism and other molecular targets of NSAIDs and the development of the platinum compounds –NSAID prodrugs.
Evaluation of The Genoprotective Effect of Curcumin Against Methotrexate in Bone Marrow and Spleen Cells in Mice
Authors: Maryoosh Taif mohammed , Ali Faris Hassan  , Sajida  H.  Ismael  , Ahmed Hussein Saihood  , Kasim S. Hmood  , Nada N Al-Shawi  
Published: January 2024

Curcumin is a yellow pigment produced from the rhizomes of the Curcuma longa plant and a primary chemo preventive component of turmeric is used as a spice and food coloring ingredient. Curcumin has a large number of pharmacological activities, such as anticancer, anti-diabetic, antioxidant, anti-infectious, and anti-inflammatory properties.Investigation of the geno-protective effect of curcumin on methotrexate induces chromosomal aberrations of spleen and bone marrow cells. In this study, 32 mice were used and divided into four groups (eight mice at each group) as follows: Group1 (negative control): Dimethyl sulfoxide was given intraperitoneally to mice every day for ten days.Group2 (positive control): Mice were received a single dose (20mg/kg) of methotrexate intraperitoneally Group3: Mice were received (200mg/kg) of curcumin solution intraperitoneally for ten successive days.Group4: Mice were received (200mg/kg) of curcumin solution intraperitoneally for ten successive days and on the day 11, a single dose of methotrexate ( 20 mg/kg ) was injected intraperitoneally . In animals treated with methotrexate, significant elevations of the chromosomal aberrations were observed along with a decline in the mitotic index. Meanwhile, there was a considerable elevation of the mitotic index and no detectable chromosomal changes in the curcumin-supplemented mice. The number of abnormal cells was reduced significantly in the curcumin-treated group in comparison with the methotrexate-treated group. The ability of curcumin to inhibit methotrexate's cytotoxic effects was shown by the compound's ability to raise the mitotic index. According to this finding, curcumin approved to be a protective agent against genotoxic effects of methotrexate.
Keywords: Curcumin, Chromosomal aberrations, Methotrexate, Mitotic index, Mice