bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the risk governance of fraudulent reimbursement of patient consultation fees
Authors: Sun Jiangjie , Wang Yue , Zhang Yuqing , Li Limin , Li Hui , Liu Tong , Zhang Liping 
Published: February 2024

BackgroundThe fundamental medical insurance fund, often referred to as the public’s “life-saving fund,” plays a crucial role in both individual well-being and the pursuit of social justice. Medicare fraudulent claims reduce “life-saving money” to “Tang’s monk meat”, undermining social justice and affecting social stability.MethodsWe utilized crawler technology to gather textual data from 215 cases involving fraudulent health insurance claims. Simultaneously, statistical data spanning 2018 to 2021 was collected from the official websites of the China Medical Insurance Bureau and Anhui Medical Insurance Bureau. The collected data underwent comprehensive analysis through Excel, SPSS 26.0 and R4.2.1. Differential Auto-Regressive Moving Average Model (ARIMA (p, d, q)) was used to fit the fund safety forecast model, and test the predictive validity of the forecast model on the fund security data from July 2021 to October 2023 (the fund security data of Anhui Province from September 2021 to October 2023).ResultsThe outcomes revealed that fraudulent claims by health insurance stakeholders adversely impact the equity of health insurance funds. Furthermore, the risk management practices of Medicare fund administrators influence the publication of fraudulent claims cases. Notably, differences among Medicare stakeholders were observed in the prevalence of fraudulent claims. Additionally, effective governance of fraudulent claims risks was found to have a positive impact on the overall health of healthcare funds. Moreover, the predictive validity of the forecast model on the national and Anhui province’s fund security data was 92.86% and 100% respectively.ConclusionWe propose four recommendations for the governance of health insurance fraudulent claims risk behaviors. These recommendations include strategies such as “combatting health insurance fraudulent claims to preserve the fairness of health insurance funds”, “introducing initiatives for fraud risk governance and strengthening awareness of the rule of law”, “focusing on designated medical institutions and establishing a robust long-term regulatory system”, and “adapting to contemporary needs while maintaining a focus on long-term regulation”.
Case report: Treatment of cyclobenzaprine ingestion in two dogs with intravenous intralipid therapy
Authors: Dreese Kaitlyn , Odunayo Adesola , Bucknoff Melissa C. 
Published: February 2024

IntroductionThe objective of this case series is to describe the clinical signs and outcome of cyclobenzaprine ingestion in two dogs treated with intralipid emulsion (ILE) and supportive care.Case or series summaryTwo dogs presented for evaluation of cyclobenzaprine ingestion. A 4-year-old female spayed Rat Terrier (dog 1) presented within 4 h of ingestion of cyclobenzaprine (between 9.7 and 25.9 mg/kg). The dog experienced abnormal behavior, agitation, tremors, tachycardia, and hypertension. There were no significant clinicopathological abnormalities. The dog was treated with ILE, cyproheptadine, and activated charcoal. All clinical signs resolved after treatment. A 5-month-old female intact mixed-breed dog (dog 2) presented after ingestion of an unknown amount of cyclobenzaprine 2–3 h prior to presentation. The dog experienced dull mentation, tremors, loss of gag reflex, tachycardia, and hypertension. There were no significant clinicopathological abnormalities. Orogastric decontamination was performed via gastric lavage, and activated charcoal was given via orogastric tube, followed by ILE. All clinical signs resolved after therapeutic intervention.DiscussionThis is the first report documenting clinical signs of cyclobenzaprine toxicity in two dogs followed by successful treatment with gastric emptying, ILE, and supportive care.
Investigating Influential Parameters for High-Purity Germanium Crystal Growth
Authors: Bhattarai Sanjay , Mei Dongming , Budhathoki Narayan , Dong Kunming , Warren Austin 
Published: February 2024

This paper focuses on the research and development of high-purity germanium (HPGe) crystals for detector fabrication, specifically targeting applications in rare-event physics searches. The primary objective was to produce large-scale germanium crystals weighing >1 kg with a controlled diameter of ∼10 cm and an impurity range of approximately 1010/cm 3. Ensuring structural integrity and excellent crystalline quality requires a thorough assessment of dislocation density, a critical aspect of the crystal development process. Dislocation density measurements play a crucial role in maximizing the sensitivity of HPGe detectors, and our findings confirmed that the dislocation density fell within acceptable ranges for detector fabrication. Additionally, this paper examines the segregation coefficient of various contaminants during the crystal development process. Comprehensive analysis of impurity segregation is essential for reducing contaminant quantities in the crystal lattice and customizing purification processes. This, in turn, minimizes undesired background noise, enhancing signal-to-noise ratios for rare-event physics searches and overall detector performance. The investigation included the segregation coefficients of three major acceptors and one donor in crystals grown at the University of South Dakota, providing valuable insights for optimizing crystal purity and detector efficiency.
Microbiological and Toxicological Investigations on Bivalve Molluscs Farmed in Sicily
Authors: Castello Annamaria , Alio Vincenzina , Cammilleri Gaetano , Sciortino Sonia , Macaluso Andrea , Ferrantelli Vincenzo , Dall’Ara Sonia , Pino Fiorella , Servadei Irene , Oliveri Giuseppa , Costa Antonella 
Published: February 2024

Bivalves can concentrate biological and chemical pollutants, causing foodborne outbreaks whose occurrence is increasing, due to climatic and anthropic factors that are difficult to reverse, hence the need for improved surveillance. This study aimed to evaluate the hygienic qualities of bivalves sampled along the production and distribution chain in Sicily and collect useful data for consumer safety. Bacteriological and molecular analyses were performed on 254 samples of bivalves for the detection of enteropathogenic Vibrio, Arcobacter spp., Aeromonas spp., Salmonella spp., and beta-glucuronidase-positive Escherichia coli. A total of 96 out of 254 samples, collected in the production areas, were processed for algal biotoxins and heavy metals detection. Bacterial and algal contaminations were also assessed for 21 samples of water from aquaculture implants. Vibrio spp., Arcobacter spp., Aeromonas hydrophila, Salmonella spp., and Escherichia coli were detected in 106/254, 79/254, 12/254, 16/254, and 95/254 molluscs, respectively. A total of 10/96 bivalves tested positive for algal biotoxins, and metals were under the legal limit. V. alginolyticus, A. butzleri, and E. coli were detected in 5, 3, and 3 water samples, respectively. Alexandrium minutum, Dinophysis acuminata, Lingulodinium polyedra, and Pseudonitzschia spp. were detected in water samples collected with the biotoxin-containing molluscs. Traces of yessotoxins were detected in molluscs from water samples containing the corresponding producing algae. Despite the strict regulation by the European Commission over shellfish supply chain monitoring, our analyses highlighted the need for efficiency improvement.
Improvement of Carotenoids’ Production by Increasing the Activity of Beta-Carotene Ketolase with Different Strategies
Authors: Zhou Qiaomian , Huang Danqiong , Yang Haihong , Hong Zeyu , Wang Chaogang 
Published: February 2024

Canthaxanthin is an important antioxidant with wide application prospects, and β-carotene ketolase is the key enzyme involved in the biosynthesis of canthaxanthin. However, the challenge for the soluble expression of β-carotene ketolase is that it hinders the large-scale production of carotenoids such as canthaxanthin and astaxanthin. Hence, this study employed several strategies aiming to improve the soluble expression of β-carotene ketolase and its activity, including selecting optimal expression vectors, screening induction temperatures, adding soluble expression tags, and adding a molecular chaperone. Results showed that all these strategies can improve the soluble expression and activity of β-carotene ketolase in Escherichia coli. In particular, the production of soluble β-carotene ketolase was increased 8 times, with a commercial molecular chaperon of pG-KJE8, leading to a 1.16-fold enhancement in the canthaxanthin production from β-carotene. Interestingly, pG-KJE8 could also enhance the soluble expression of β-carotene ketolase derived from eukaryotic microalgae. Further research showed that the production of canthaxanthin and echinenone was significantly improved by as many as 30.77 times when the pG-KJE8 was added, indicating the molecular chaperone performed differently among different β-carotene ketolase. This study not only laid a foundation for further research on the improvement of β-carotene ketolase activity but also provided new ideas for the improvement of carotenoid production.
Background Factors Affecting the Radiation Exposure of the Lens of the Eye among Nurses in Interventional Radiology: A Quantitative Observational Study
Authors: Kuriyama Tomoko , Moritake Takashi , Nakagami Koichi , Morota Koichi , Hitomi Go , Kitamura Hiroko 
Published: February 2024

With the International Commission on Radiological Protection’s (ICRP) reduction in the radiation dose threshold for cataracts, evaluating and preventing radiation exposure to the lens of the eye among interventional radiology (IR) staff have become urgent tasks. In this study, we focused on differences in lens-equivalent dose (HT Lens) to which IR nurses in three hospitals were exposed and aimed to identify factors underlying these differences. According to analyses of time-, distance-, and shielding-related factors, the magnitude of the HT Lens dose to which IR nurses were exposed could be explained not by time or shielding but by the distance between the X-ray exposure field and the location of the IR nurse. This distance tended to be shorter in hospitals with fewer staff. The most effective means of reducing the exposure of the lenses of IR nurses’ eyes to radiation is to position them at least two meters from the radiation source during angiography procedures. However, some hospitals must provide IR departments with comparatively few staff. In work environments where it is infeasible to reduce exposure by increasing distance, interventions to reduce time by managing working practices and investment in shielding equipment are also important. This study was not registered.
Identification of Sarcocystis and Trichinella Species in Muscles of Gray Wolf (Canis lupus) from Lithuania
Authors: Juozaitytė-Ngugu Evelina , Maziliauskaitė Evelina , Kirjušina Muza , Prakas Petras , Vaitkevičiūtė Rasa , Stankevičiūtė Jolanta , Butkauskas Dalius 
Published: February 2024

Apicomplexan Sarcocystis and Trichinella nematodes are food-borne parasites whose life cycle is carried-out in various wildlife and domestic animals. The gray wolf (Canis lupus) is an apex predator acting as an ecosystem engineer. This study aimed to identify the species of Sarcocystis and Trichinella found in the muscles of gray wolves in Lithuania. During the 2017–2022 period, diaphragm, heart, and hind leg samples of 15 animals were examined. Microscopical analysis showed the presence of two types of Sarcocystis parasites in 26.7% of the analyzed muscle samples. Based on the sequencing of five loci, nuclear 18S rDNA, 28S rDNA, ITS1, mitochondrial cox1, and apicoplast rpoB, S. arctica, and S. svanai were identified. The current work presents the first report of S. svanai in gray wolf. Phylogenetically, S. svanai clustered together with S. lutrae, infecting various carnivorans, and S. arctica was most closely related to S. felis from domestic cats. Trichinella spp. were found in 12 gray wolves (80%). For the first time, Trichinella species were molecularly identified in gray wolves from Lithuania. Trichinella britovi was confirmed in all of the isolated Trichinella larvae using a multiplex PCR. Gray wolves in Lithuania may serve as a major source of zoonotic pathogens due to the presence of these parasites.
Analisa Proksimat dan Kadar Kafein Pada Green Bean Robusta Berdasarkan Lama Waktu Fermentasi
Authors: Rosdiana Eva , Nirmala Kusumaningtyas Rizky , Galuh Pratita Dian , Lutfi Alwi Annisa , Rahayu Sri 
Published: February 2024

Coffee is one of the commodities that provide additional foreign exchange for Indonesia. This is supported by the position of the country of Indonesia which is the number 4 producer of coffee beans in the world. One type of coffee that is cultivated in Indonesia is Robusta coffee. Robusta coffee is known as coffee that is resistant to various diseases and extreme environments, has superior properties and is very fast growing, therefore Robusta coffee is widely chosen to be planted by Indonesian. One of the step at coffee processing by full wash processing is fermentation. Fermentation is a process that produces chemical reactions involving other microorganism that breaking down polysaccharide into enzyme and monosaccharide. That process itself is influenced by several factors, including the number of bacterial inoculum, fermentation time, substrate (medium), temperature, oxygen, water and acidity (pH). The incubation period of fermentation is the most step that determine the quality of coffee. The purpose of this study was to determine the effect of the length of fermentation time on the wet coffee processing method on green beans robusta that produced by looking at several chemical parameters, including water content, ash content, fat content, carbohydrate content and caffeine content. The results showed that variations in fermentation time had a significant effect on the parameters of water content, ash, carbohydrates, fat and caffeine.
HIF2α Promotes Cancer Metastasis through TCF7L2-Dependent Fatty Acid Synthesis in ccRCC
Authors: Shi Jian , Lv Qingyang , Miao Daojia , Xiong Zhiyong , Wei Zhihao , Wu Songming , Tan Diaoyi , Wang Keshan , Zhang Xiaoping 
Published: February 2024

Recent studies have highlighted the notable involvement of the crosstalk between hypoxia-inducible factor 2 alpha (HIF2α) and Wnt signaling components in tumorigenesis. However, the cellular function and precise regulatory mechanisms of HIF2α and Wnt signaling interactions in clear cell renal cell carcinoma (ccRCC) remain elusive. To analyze the correlation between HIF2α and Wnt signaling, we utilized the Cancer Genome Atlas - Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) public database, HIF2α RNA sequencing data, and conducted luciferase reporter assays. A Wnt-related gene set was employed to identify key regulators of Wnt signaling controlled by HIF2α in ccRCC. Furthermore, we assessed the biological effects of TCF7L2 on ccRCC metastasis and lipid metabolism in both in vivo and in vitro settings. Our outcomes confirm TCF7L2 as a key gene involved in HIF2α-mediated regulation of the canonical Wnt pathway. Functional studies demonstrate that TCF7L2 promotes metastasis in ccRCC. Mechanistic investigations reveal that HIF2α stabilizes TCF7L2 mRNA in a method based on m
6
A by transcriptionally regulating METTL3. Up-regulation of TCF7L2 enhances cellular fatty acid oxidation, which promotes histone acetylation. This facilitates the transcription of genes connected to epithelial–mesenchymal transition and ultimately enhances metastasis of ccRCC. These outcomes offer a novel understanding into the involvement of lipid metabolism in the signaling pathway regulation, offering valuable implications for targeted treatment in ccRCC.
Resistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System
Authors: Yang Han-Mo , Kim Joonoh , Kim Baek-Kyung , Seo Hyun Ju , Kim Ju-Young , Lee Joo-Eun , Lee Jaewon , You Jihye , Jin Sooryeonhwa , Kwon Yoo-Wook , Jang Hyun-Duk , Kim Hyo-Soo 
Published: February 2024

Resistin plays an important role in the pathophysiology of obesity-mediated insulin resistance in mice. However, the biology of resistin in humans is quite different from that in rodents. Therefore, the association between resistin and insulin resistance remains unclear in humans. Here, we tested whether and how the endocannabinoid system (ECS) control circulating peripheral blood mononuclear cells (PBMCs) that produce resistin and infiltrate into the adipose tissue, heart, skeletal muscle, and liver, resulting in inflammation and insulin resistance. Using human PBMCs, we investigate whether the ECS is connected to human resistin. To test whether the ECS regulates inflammation and insulin resistance in vivo, we used 2 animal models such as “humanized” nonobese diabetic/Shi-severe combined immunodeficient interleukin-2Rγ (null) (NOG) mice and “humanized” resistin mouse models, which mimic human body. In human atheromatous plaques, cannabinoid 1 receptor (CB1R)-positive macrophage was colocalized with the resistin expression. In addition, resistin was exclusively expressed in the sorted CB1R-positive cells from human PBMCs. In CB1R-positive cells, endocannabinoid ligands induced resistin expression via the p38–Sp1 pathway. In both mouse models, a high-fat diet increased the accumulation of endocannabinoid ligands in adipose tissue, which recruited the CB1R-positive cells that secrete resistin, leading to adipose tissue inflammation and insulin resistance. This phenomenon was suppressed by CB1R blockade or in resistin knockout mice. Interestingly, this process was accompanied by mitochondrial change that was induced by resistin treatment. These results provide important insights into the ECS–resistin axis, leading to the development of metabolic diseases. Therefore, the regulation of resistin via the CB1R could be a potential therapeutic strategy for cardiometabolic diseases.
Peran Kampus sebagai Wadah Pencetak Generasi Moderasi Beragama
Authors: Aini Huril , Munir Misbachol , Munafiah Nida'ul 
Published: February 2024

Moderasi beragama sejatinya adalah menciptakan insan-insan yang memahami agama secara baik, mendalam, dan mengimplementasikan dengan cara yang baik. Kampus tidak hanya menjadi tempat pendidikan formal, tetapi juga dapat dijadikan wadah yang mempromosikan pemahaman agama yang moderat dan kerjasama antaragama. Metode yang digunakan adalah studi pustaka (library research), yaitu pengumpulan data dengan cara mencari sumber dan merkontruksi dari berbagai sumber seperti buku, jurnal, dan riset-riset yang sudah ada. Penelitian ini bertujuan membahas bagaimana peran kampus dalam menanamkan moderasi beragama kepada generasi muda. Hasil penelitian menjelaskan bahwa moderasi beragama merupakan konsep yang mengacu pada sikap, pemahaman, dan praktik keagamaan yang seimbang, toleran, dan menghormati perbedaan dalam hal keyakinan agama dan spiritualitas. Kampus sebagai lembaga pendidikan dapat menjadi salah satu wadah yang mampu mencetak generasi penerus yang memiliki jiwa moderat melalui pembentukan lingkungan, pendidikan yang toleran, kurikulum yang mendukung moderasi beragama, kegiatan ekstrakurikuler dan pengembangan diri.
Outcome of laser Treatment for Retinopathy of Prematurity
Authors: Panggalo Idayani , Muhidin Habibah S , Ichsan Andi Muhammad , Budu  , Suryanita Andi , Windy Dyah Ayu 
Published: February 2024

Introduction & ObjectivesRetinopathy of prematurity is a proliferative disorder that requires urgent treatment. Proper casefinding and treatment will prevent permanent blindness in infants. Laser photocoagulation is anpreferred technique for the treatment of ROP. Aim of this study to describe the result of laserindirect Ophthalmoscopy in Makassar, South Sulawesi, Indonesia.
MethodsThis is Observational retrospective study, from 1130 screening procedures during 2020 until 2022.This study found 41 ROP patients who had received therapy.
ResultsFrom 43 patients who received therapy, most were ROP stage 3 (80%), APROP (19%) and the restwere Stage IV A . 40 infants received lasers photocoagulation, and one infant received both laserphotocoagulation and intravitreal anti-VEGF. Regression was found in all cases of stage 3 ROP.Patients with aggressive posterior ROP also were treated successfully, except one patientprogressed to stage 4 ROP.
Conclusionwith screening and prompt treatment, good outcomes have been obtained for infants with ROP
SELECTIVE LASER TRABECULOPLASTY AS A VALUEABLE MODALITY OF TREATMENT IN OPEN ANGLE GLAUCOMA PATIENT
Authors: TRIANGGADEWI DYAH PURWITA , Umbara Sonie , Rifada R Maula , Gustianty Elsa , Prahasta Andika 
Published: February 2024

Introduction & ObjectivesSelective Laser Trabeculoplasty (SLT) has became an established treatment to lower intraocularpressure (IOP) for open angle glaucoma (OAG) and ocular hypertension. The aim of this study was toevaluate IOP lowering effect of SLT and correlate its laser parameter to the successful rate in OAG.
MethodsThis is a prospective study of seventeen eyes OAG patients in Cicendo Eye Hospital from 1stNovember 2022 to 31th December 2022. SLT performed once in OAG with uncontrolled IOP (IOP >21 mmHg). Outcome measured were IOP at post laser, 1week , 1 month, and 2 months of follow upafter SLT. Successful criteria determined as greater than 20% IOP reduction. Correlation betweensetting operational of SLT and primary outcome were measured. Student’s t-test (two-tailed,dependent) has been used to find the significance of study parameters.
ResultsA total 17 eyes underwent SLT. Mean baseline IOP was 21,12 ? 4,0 mmHg. IOP was significantlydecreased from baseline post laser 18,06 ? 3,17 mmHg; at 1 week 17,06 ? 3,25 mmHg; 1 month15,53 ? 4,52 mmHg; and at 2 month follow up 15,47 ? 4,02 mmHg (p<0,001). The successful rate ofSLT after two months follow up from this study were 76,5% samples (13 eyes). Mean of total laserenergy was 75,6 ? 16,8 mJ. There was correlation between total laser energy with percentage of 1month IOP reduction (coefficient : 0,470 (p<0,029)).
ConclusionSLT is effective and safe for reducing IOP in open angle glaucoma patient.
MEMBANGUN KOMUNIKASI INTERKULTURAL MELALUI PERTUKARAN BUDAYA TRADISIONAL INDONESIA-THAILAND
Authors: Yuslian Toni Ridho , Putri Ananda Ririn , Trisna Ayuh Eceh , Ausanun Hasiah , Enggar Sasono Bayu 
Published: February 2024

Islamwittaya Foundation School adalah salah satu sekolah di kawasan Khuan Don Subdistrict, Satun, Thailand Selatan. Sekolah ini terdiri dari berbagai tingkatan, seperti annuban (taman kanak-kanak), Phattom (sekolah dasar), dan Matthayom (sekolah menengah dan atas). Pendidikan yang berbasis dua kurikulum yakni kurikulum general dan kurikulum islami menjadikan sekolah ini salah satu sekolah yang memiliki siswa dari beragam budaya dan latar belakang sosial. Selain itu, sekolah ini berkerja sama dengan Association of Education Cultural International (AECI) untuk mendatangkan mahasiswa dari Indonesia dalam program asistensi mengajar setiap bulannya. Dalam hal ini komunikasi interkultural sangat berperan penting dalam menjalin hubungan mahasiswa dan siswa yang memiliki kebudayaan yang berbeda untuk mencapai tujuan pembelajaran yang efektif. Pembelajaran efektif tersebut dapat tercapai apabila mahasiswa dan siswa memiliki keterbukaan untuk saling mengajari dan mempelajari kebudayaan yang mereka punya melalui komunikasi interpersonal. Dari hal tersebut, digunakan pendekatan-pendekatan interaktif yang dirancang sesuai dengan usia, latar belakangan, dan kondisi sosial untuk menumbuhkan kesadaran dan rasa toleransi siswa terhadap kebudayaan lokal dan baru. Sehingga terbentuklah generasi yang menghormati, menjaga, dan sadar akan budaya melalui komunikasi interkultural.