bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of crop simulation modeling in assessing potential climate change impacts
Authors: Timlin Dennis , Paff Kirsten , Han Eunjin 
Published: January 2024

AbstractAgriculture is weather dependent, and changes in climate can have a drastic impact on our ability to feed, fuel, and clothe the world's population. Climate change is causing more frequent and unprecedented extreme weather events that are already negatively affecting agriculture. We need to assess the effects of extreme temperatures and rainfall on agriculture. Patterns of short‐term extreme weather events, such as elevated temperatures, flooding, and strong winds, are not predictable enough to design field experiments around. Process‐based crop and soil simulation models allow us to explore new management options and thus provide whole‐system‐based knowledge and management guides for different locations over variable climate conditions. By using crop simulation models, researchers can test different adaptation strategies and assess their effectiveness in reducing the impacts of climate change on agricultural production. In this paper, we discuss the development of crop models and how they have been used to assess the effects of a changing climate on agricultural productivity and propose methods for agriculture to adapt to those changes. We describe potential applications of crop models to assess regional issues such as irrigation demand, greenhouse gas emissions, and policy decisions. Better understanding of how weather and climate forecasts at various scales are provided and the reliability of these forecasts is important for using crop models as a planning tool. Different approaches for simulating long‐term climate change impacts on crop yield and seasonal yield forecasting are discussed. The use of ensemble models to better assess climate change impacts is also discussed.
Three years of cover crops management increased soil organic matter and labile carbon pools in a subtropical vegetable agroecosystem
Authors: Nyabami Precious , Weinrich Ethan , Maltais‐Landry Gabriel , Lin Yang 
Published: January 2024

AbstractCover crops have been widely adopted to improve soil functions in agroecosystems, including providing carbon (C) inputs that can contribute to soil C sequestration. However, soil C changes may be slow after introducing cover crops in unfavorable environments for soil organic matter (SOM) accumulation, like the Southeast United States subtropical region characterized by a warm humid climate, and coarse‐textured soils. We examined labile C pools as potential early indicators of SOM changes after cover crop introduction in a sandy subtropical vegetable production system. We compared the effects of four cover crop monocultures namely two grasses [sorghum sudangrass, Sorghum bicolor × S bicolor var. Sudanese and pearl millet, Pennisetum glaucum (L.) R. Br.], two legumes (sunn hemp, Crotalaria juncea L., and cowpea, Vigna unguiculata Walp.), and one four‐species mixture on soil organic carbon pools for 3 years. Soil samples were collected at a 15‐cm depth before cover crop planting and post cover crop incorporation to assess changes in SOM, permanganate‐oxidizable carbon (POX‐C), mineralizable carbon (Cmin), and water extractable organic carbon (WEOC). The incorporation of cover crops increased concentrations of SOM, POX‐C, and Cmin in year 3 relative to their baseline values in year 1. Concentration of SOM increased by 0.24 ± 0.05% (mean ± standard error) after 3 years of cover crop management. However, concentrations of WEOC significantly decreased in years 2 and 3 relative to the baseline. Monocultures and the mixture had similar effects on measured C pools, likely due to comparable aboveground biomass production. Our findings highlight the potential of POX‐C and Cmin as early indicators of SOM accumulation driven by cover crops use, as well as the capacity of cover crops to build SOM in similar subtropical systems and coarser textured soils.
Oxygen‐driven cuproptosis synergizes with radiotherapy to potentiate tumor immunotherapy
Authors: Pei Pei , Wang Yuhong , Shen Wenhao , He Qing , Han Xiangming , Zhang Chonghai , Xie Yuyuan , Zhou Guangming , Zhao Ye , Hu Lin , Yang Kai 
Published: January 2024

AbstractThe immunological implications of cuproptosis, a form of cell death highly sensitive to oxygen presence, remain largely unexplored in the context of tumor immunotherapy. Herein, we initially investigate the positive correlation between cuproptosis and tumor immunotherapy through bioinformatics analysis. Subsequently, an oxygen generator loaded with copper ions (Cu/APH‐M) has been constructed, which serves as an effective carrier of copper ions and crucially enhances the oxygenation of the tumor microenvironment. Importantly, Cu/APH‐M‐mediated dual strengthening of cuproptosis and radiotherapy could not only trigger a powerful antitumor immunity related to immunogenic cell death by RNA‐sequencing analysis, but also effectively inhibit the growth of both distal and in situ low rectal tumors after combined immunotherapy, creating a robust immune memory effect. Our work reveals the beneficial effects of enhanced cuproptosis in radio‐immunotherapy and elucidates its underlying mechanisms, which provides a novel approach for the synergistic integration of cuproptosis with immunotherapy and radiotherapy, broadening the scope of cuproptosis‐mediated tumor therapy.
Pickering multiphase materials using plant‐based cellulosic micro/nanoparticles
Authors: Liu Wei , Pang Bo , Zhang Meng , Lv Jiayi , Xu Ting , Bai Long , Cai Xu‐Min , Yao Shuangquan , Huan Siqi , Si Chuanling 
Published: January 2024

AbstractPickering multiphase systems stabilized by solid particles have recently attracted increasing attention due to their excellent stability. Among various solid stabilizers, natural and renewable cellulosic micro/nanoparticles that are derived from agricultural and forestry sources have become promising candidates for Pickering stabilization due to their unique morphological features and tunable surface properties. In this review, recent progress on forming and stabilizing Pickering multiphase systems using cellulosic colloidal particles is summarized, including the physicochemical factors affecting their assembly at the interfaces and the preparation methods suitable for producing Pickering emulsions. In addition, relevant application prospects of corresponding Pickering multiphase materials are outlined. Finally, current challenges and future perspectives of such renewable Pickering multiphase systems are presented. This review aims to encourage the utilization of cellulosic micro/nanoparticles as key components in the development of Pickering systems, leading to enhanced performance and unique functionalities.
Evaluation of the characteristics of injured workers and employer compliance with OSHA's reporting requirement for work‐related amputations
Authors: Reilly Mary Jo , Wang Ling , Rosenman Kenneth D. 
Published: January 2024

AbstractIntroductionIn 2014, the Federal Occupational Safety and Health Administration (OSHA) enacted a standard requiring employers to report work‐related amputations to OSHA within 24 hours. We studied the characteristics of the injured workers and employer compliance with the regulation in Michigan.MethodsTwo independent data sets were used to compare work‐related amputations from 2016 to 2018: employer reports to OSHA and the Michigan Multi‐Source Injury and Illness Surveillance System (MMSIISS). We deterministically linked employer reports to OSHA with the MMSIISS by employee name, employer name, date, and type of amputation.ResultsWe identified 1366 work‐related amputations from 2016 to 2018; 575 were reported by employers to OSHA and 1153 were reported by hospitals to the MMSIISS. An overlap of 362 workers were reported in both systems, while 213 workers were only reported by employers to OSHA and 791 workers were only reported by hospitals. Employer compliance with the regulation was 42.1%. Employer compliance with reporting was significantly less in: agriculture, forestry, fishing, and hunting (14.6%); construction (27.4%); retail trade (20.7%); arts, entertainment, and recreation (7.7%); accommodation and food services (13.0%); and other services (27.0%). Large employers and unionized employers were significantly more likely (67.9% and 92.7%, respectively) and small employers were significantly less likely (18.2%) to comply with the reporting rule. Enforcement inspections at 327 workplaces resulted in 403 violations; of those, 179 (54.7%) employers had not corrected the amputation hazard before the time of inspection.DiscussionMichigan employers reported less than half of the work‐related amputations required by OSHA's reporting regulation. Noncompliance was greatest in small employers, and agriculture, forestry, fishing, and hunting; construction; arts, entertainment, and recreation; accommodation and food services; and retail and other service industries. Inspections found that over half of the employers had not corrected the hazard that caused the amputation at the time of the inspection's initial opening date; in these cases, abatement of any hazards identified would have occurred after the inspection. Improved compliance in employer reporting of work‐related amputations will identify hazards posing a high risk of recurrence of injury to other workers from the same injury source. Greater compliance can also help target safety‐related preventive and intervention efforts in industries that might otherwise be overlooked.
Nuclear modification factor for quarkonium production in high energy proton‐nucleus collisions within the parton saturation approach
Authors: Rocha Érison S. , Machado Magno V. T. 
Published: January 2024

AbstractIn this work, we analyze nuclear effects in the inclusive production of quarkonium in proton‐nucleus collisions at high energy regime. A theoretical framework that includes initial state effects like nuclear shadowing and gluon density saturation is considered. Numerical results for nuclear modification factor, , as a function of meson rapidity in proton‐nucleus collisions are presented. The parameter‐free predictions are compared to the available data from the Large Hadron Collider. Discussion on the main theoretical uncertainties is made, with emphasis on the phenomenological models for the nuclear saturation scale.
Sexually and non‐sexually transmitted infections and the risk of prostate cancer: Results from the EPICAP study
Authors: Sawaya Melissa , Cordina‐Duverger Emilie , Lamy Pierre‐Jean , Rébillard Xavier , Trétarre Brigitte , Menegaux Florence 
Published: January 2024

AbstractIntroductionProstate cancer (PCa) is by far the most common type of cancer among men in western countries. However, relatively little is known about its etiology despite the high morbidity and mortality. It has been suggested that chronic inflammation may be involved in prostate carcinogenesis. We investigated the role of sexually and non‐sexually transmitted infections in prostate cancer risk with a specific interest in the aggressive types.MethodsWe used data from epidemiological study of prostate cancer (EPICAP), a population‐based case–control study. A total of 819 incident cases and 879 controls were interviewed face‐to‐face using a standardized questionnaire gathering information on known or suspected risk factors of prostate cancer and personal history of specific sexually and non‐sexually transmitted infections: gonorrhea, syphilis, trichomonas, herpes, mononucleosis, Epstein–Barr virus, varicella‐zoster, and dengue. Odds ratios (OR) and their 95% confidence interval were estimated using multivariate unconditional logistic regression.ResultsThere was no significant association between gonorrhea (OR: 0.90, 95% CI: 0.61–1.33), trichomonas (OR: 0.74, 95% CI: 0.27–2.07), genital herpes (OR: 0.69, 95% CI: 0.38–1.27), and the risk of prostate cancer. No association emerged for overall sexually transmitted bacterial and viral infections (OR 1.05, 95% CI: 0.86–1.29) and overall non‐sexually transmitted viral infections (OR 1.11, 95% CI: 0.90–1.35) and the risk of prostate cancer.ConclusionOur results showed that sexually or non‐sexually transmitted infections, either bacterial or viral, were not associated to prostate cancer. Therefore, further investigation is needed to help advance our understanding of the role of chronic inflammation in the etiology of prostate cancer, with a particular focus on its most aggressive types.
Early diagnosis of thoracic spinal dural arteriovenous fistula using lumbar magnetic resonance imaging: A case report
Authors: Kyaw May Pyae , Tanaka Tatsuya , Anai Satoshi , Takase Yukinori , Kamitoko Kiku , Minagawa Hiromu , Yukitake Motohiro , Sasaki Junpei , Nagata Oya , Matsuno Akira , Morimoto Tadatsugu 
Published: January 2024

Key Clinical MessageIn middle‐aged and older men, clinicians often suspect lumbar spine disease when gait is impaired with intermittent claudication, but spinal dural arteriovenous fistula (SDAVF) may be the etiology. An understanding of the key magnetic resonance imaging findings of SDAVF is necessary for early diagnosis, appropriate treatment, and minimization of complications.
Management of a permanent lateral incisor with a talon cusp and immature apex: A case report
Authors: van der Vyver Peet , Potgieter Nicoline , Vorster Martin 
Published: January 2024

Key Clinical MessageThis case report focuses on the diagnosis and treatment of a maxillary lateral incisor affected by a talon cusp, a rare developmental dental anomaly. The case presented with irreversible pulpitis and an immature apex. The article discusses the prevalence, etiology, classification, and treatment options for talon cusps, highlighting their clinical significance and potential complications. Clinical and radiographic findings obtained from a periapical radiograph and a cone‐beam computed tomography (CBCT) scan are outlined. The treatment approach involved the removal of the talon cusp, endodontic therapy including apexification with mineral trioxide aggregate, and aesthetic restoration of the tooth. The report underscores the value of precise diagnosis, careful treatment planning, and the utility of CBCT scans in effectively managing talon cusps.
Preparation of carbon‐coated Fe2O3@Ti3C2Tx composites by mussel‐like modifications as high‐performance anodes for lithium‐ion batteries
Authors: Li Shaoqing , Ye Yong , Liu Xiang , Yang Xuerui , Fang Shan , Zhou Naigen 
Published: January 2024

AbstractFe2O3 with high theoretical capacity (1007 mA h g−1) and low cost is a potential anode material for lithium‐ion batteries (LIBs), but its practical application is restricted by its low electrical conductivity and large volume changes during lithiation/delithiation. To solve these problems, Fe2O3@Ti3C2Tx composites were synthesized by a mussel‐like modification method, which relies on the self‐polymerization of dopamine under mild conditions. During polymerization, the electronegative group (−OH) on dopamine can easily coordinate with Fe3+ ions as well as form hydrogen bonds with the −OH terminal group on the surface of Ti3C2Tx, which induces a uniform distribution of Fe2O3 on the Ti3C2Tx surface and mitigates self‐accumulation of MXene nanosheets. In addition, the polydopamine‐derived carbon layer protects Ti3C2Tx from oxidation during the hydrothermal process, which can further improve the electrical conductivity of the composites and buffer the volume expansion and particle agglomeration of Fe2O3. As a result, Fe2O3@Ti3C2Tx anodes exhibit ~100 % capacity retention with almost no capacity loss at 0.5 A g−1 after 250 cycles, and a stable capacity of 430 mA h g−1 at 2 A g−1 after 500 cycles. The unique structural design of this work provides new ideas for the development of MXene‐based composites in energy storage applications.
Recycalyse – New Sustainable and Recyclable Catalytic Materials for Proton Exchange Membrane Electrolysers
Authors: Melke Julia , Maletzko Annabelle , Gomez Villa Eduardo Daniel , Bornet Aline , Wiberg Gustav K. H. , Arenz Matthias , Sandig-Predzymirska Lesia , Thiere Alexandra , Charitos Alexandros , Stelter Michael , Wang Zhangqi , Pitscheider Simon , Bertheussen Erlend , Pedersen Christoffer M. , Finsdóttir Sára , Kokborg Morten S. , Berman Daniel G. , Dalvang Simone , Müller Sebastian S. , Seidel Fabian , Seselj Nedjeljko , Höglinger Martin , Kartusch Stefan , Eder Joshua , Macherhammer Marie , Trattner Alexander , Kallesøe Christian 
Published: January 2024

AbstractWithin the Recycalyse project different research organization and industrial partners worked together to develop catalysts for the oxygen evolution reaction for proton exchange membrane electrolysis that reduce the use of critical raw materials. The catalysts are applied to polymer electrolyte membranes via a direct coating process and tested both in single cells and at stack level. In order to reduce the dependence on material imports in Europe in the long term, recycling is considered for the catalysts, electrodes and the entire system.
Optimized massively parallel solving of N‐Queens on GPGPUs
Authors: Pantekis Filippos , James Phillip , Kullmann Oliver , O'Reilly Liam 
Published: January 2024

SummaryContinuous evolution and improvement of GPGPUs has significantly broadened areas of application. The massively parallel platform they offer, paired with the high efficiency of performing certain operations, opens many questions on the development of suitable techniques and algorithms. In this work, we present a novel algorithm and create a massively parallel, GPGPU‐based solver for enumerating solutions of the N‐Queens problem. We discuss two implementations of our algorithm for GPGPUs and provide insights on the optimizations we applied. We also evaluate the performance of our approach and compare our work to existing literature, showing a clear reduction in computational time.
Mechanism of gambogic acid repressing invasion and metastasis of colorectal cancer by regulating macrophage polarization via tumor cell‐derived extracellular vesicle‐shuttled miR‐21
Authors: Li You , Liao Wenqi , Huang Wei , Liu Fenglin , Ma Lin , Qian Xiaoping 
Published: January 2024

AbstractColorectal cancer (CRC) is a major cause of mortality and morbidity. Gambogic acid (GA) is a promising antitumor drug for treating CRC. We aimed to elucidate its mechanism in CRC invasion/metastasis via tumor cell‐derived extracellular vesicle (EV)‐carried miR‐21. Nude mice peritoneal carcinomatosis (PC) model was subjected to GA treatment liver collection, followed by observation/counting of metastatic liver tissues/liver metastatic nodules by hematoxylin and eosin staining. miR‐21 expression in metastatic liver tissues/CD68 + CD86, CD68 + CD206 cell percentages and M2 macrophage marker CD206 level in tumor tissues/interleukin (IL)‐12 and IL‐10 levels were determined by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR)/flow cytometry/enzyme‐linked immunosorbent assay. HT‐29 cells were treated with GA/miR‐21 mimics/negative control for 48 h. miR‐21 expression/cell proliferation/migration/invasion/apoptosis were assessed by RT‐qPCR/cell counting kit‐8/scratch assay/transwell assay/flow cytometry. EVs were extracted from HT‐29 cells and identified by transmission electron microscope/nanoparticle tracking analysis/Western blot. IL‐4/IL‐13‐induced macrophages/PC nude mice were treated with GA and EVs, with the internalization of EVs by macrophages assessed through the uptake test. After intraperitoneal injection of GA, PC nude mice exhibited decreased tumor cell density/irregular cell number/liver metastatic nodule number/miR‐21 expression, and CRC cells manifested reduced CD68 + CD206 cells/IL‐10/miR‐21/proliferation/migration/invasion and increased CD68 + CD86 cells/IL‐12/apoptosis, while these trends were opposite after miR‐21 overexpression, implying that GA curbed CRC/cell invasion/metastasis and macrophage polarization by diminishing miR‐21 levels. miR‐21 was encapsulated in HT‐29 cell‐derived EVs. M2 polarization elevated CD206 cells/IL‐10, which were decreased by simultaneous GA treatment. EVs could be uptaken by macrophages. CRC cell‐EV‐miR‐21 annulled the suppression effects of GA on macrophage M2 polarization. GA suppressed macrophage M2 polarization by lessening tumor cell derived‐EV‐shuttled miR‐21, thereby weakening CRC invasion/metastasis.
Prevalence of carboxy‐Δ8‐tetrahydrocannabiniol in antidoping samples
Authors: Nair Vinod S. , Heybroek Mari , Boyle Emily , Rogers Mason , Campbell Thane , Eichner Daniel , Hill Kevin 
Published: January 2024

AbstractΔ9‐Tetrahydrocannabinol (Δ9‐THC) is usually the primary psychoactive agent in cannabis preparations. Recently, products containing another isomer, Δ8‐tetrahydrocannabinol (Δ8‐THC), have become available for sale. Δ8‐THC exists naturally in the cannabis plant at very low concentrations; hence, the Δ8‐THC present in most of the above‐mentioned products is likely to be manufactured synthetically. A surge in popularity of these products, coupled with little oversight to ensure purity and potency, has led to reports of adverse events. Workplace drug testing programs as well as many sporting organizations prohibit the use of cannabinoids. Carboxy‐Δ9‐THC (Δ9‐THC‐COOH) is the targeted urinary metabolite for detection of cannabis use. The proliferation of products containing Δ8‐THC, which metabolizes to Δ8‐THC‐COOH, presents analytical complexity with respect to separation and quantification of the individual isomers as well as legal complexity with respect to lack of clarity around the legal status of Δ8‐THC. This study aims to estimate the prevalence of Δ8‐THC use in the athlete community by monitoring for Δ8‐THC‐COOH in samples collected for antidoping. A high‐performance liquid chromatography tandem mass spectrometry (LC–MS/MS) method was utilized to resolve Δ8 and Δ9‐THC‐COOH. One thousand samples with a presumptive Δ9‐THC‐COOH finding in routine screening were analyzed by the above LC–MS/MS method. Approximately 12% of samples contained Δ8‐THC‐COOH at relative abundances between 5% and 100% of total carboxy‐THC content.
GLGPGVG derived from bovine elastin repairs UV‐induced photoaging in human foreskin fibroblasts and its potential bioavailability
Authors: Sun Huaxing , Liu Liyu , Liu Yang , Wang Shuguang , Hua Yanglin , Zhao Mouming , Su Guowan 
Published: January 2024

AbstractStudies have indicated the potential of oral elastin hydrolysates in repairing photoaging skin. To reveal the underlying mechanism, this study examined how two elastin‐derived peptides (Gly‐Leu‐Gly‐Pro‐Gly‐Val‐Gly [GLGPGVG] and Pro‐Tyr [PY]) repair ultraviolet (UV)‐induced damage in human foreskin fibroblasts (HFFs) and explored their digestive stability using UPLC‐MS/MS. Results showed that UV‐damaged HFFs treated with GLGPGVG showed higher superoxide dismutases (SOD) activity and cell viability compared with PY treatment. Furthermore, GLGPGVG even reversed UV‐induced increase in reactive oxygen species, MMP‐12 (elastase), elastin mRNA and intercellular Ca2+ levels, and decrease in elastin content. Intriguingly, in vitro digestion products from GLGPGVG retained approximately 60% of elastase inhibitory activity. Furthermore, a portion of GLGPGVG was observed to pass through the Caco‐2 monolayer intact. These findings revealed that elastin‐derived peptide GLGPGVG holds promise for passing through the gastrointestinal tract and exerting protective effects against photoaging through increasing SOD activity and inhibiting MMP‐12 expression.