bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneity in cardiorenal protection by Sodium glucose cotransporter 2 inhibitors in heart failure across the ejection fraction strata: Systematic review and meta-analysis
Authors: Taheri Saeed 
Published: December 2023

BACKGROUND
Gliflozins or Sodium glucose cotransporter 2 inhibitors (SGLT2i) are relatively novel antidiabetic medications that have recently been shown to represent favorable effects on patients’ cardiorenal outcomes. However, there is shortage of data on potential disparities in this therapeutic effect across different patient subpopulations.
AIM
To investigate differential effects of SGLT2i on the cardiorenal outcomes of heart failure patients across left ventricular ejection fraction (LVEF) levels.
METHODS
Literature was searched systematically for the large randomized double-blind controlled trials with long enough follow up periods reporting cardiovascular and renal outcomes in their patients regarding heart failure status and LVEF levels. Data were then meta-analyzed after stratification of the pooled data across the LVEF strata and New York Heart Associations (NYHA) classifications for heart failure using Stata software version 17.0.
RESULTS
The literature search returned 13 Large clinical trials and 13 post hoc analysis reports. Meta-analysis of the effects of gliflozins on the primary composite outcome showed no significant difference in efficacy across the heart failure subtypes, but higher efficacy were detected in patient groups at lower NYHA classifications (I 2 = 46%, P = 0.02). Meta-analyses across the LVEF stratums revealed that a baseline LVEF lower than 30% was associated with enhanced improvement in the primary composite outcome compared to patients with higher LVEF levels at the borderline statistical significance (HR: 0.70, 95%CI: 0.60 to 0.79 vs 0.81, 95%CI: 0.75 to 0.87; respectively, P = 0.06). Composite renal outcome was improved significantly higher in patients with no heart failure than in heart failure patients with preserved ejection fraction (HFpEF) (HR: 0.60, 95%CI: 0.49 to 0.72 vs 0.94, 95%CI: 0.74 to 1.13; P = 0.04). Acute renal injury occurred significantly less frequently in heart failure patients with reduced ejection fraction who received gliflozins than in HFpEF (HR: 0.67, 95%CI: 51 to 0.82 vs 0.94, 95%CI: 0.82 to 1.06; P = 0.01). Volume depletion was consistently increased in response to SGLT2i in all the subgroups.
CONCLUSION
Heart failure patients with lower LVEF and lower NYHA sub-classifications were found to be generally more likely to benefit from therapy with gliflozins. Further research are required to identify patient subgroups representing the highest benefits or adverse events in response to SGLT2i.
Anesthesia training: Are we doing enough in three years? Cross-sectional study
Authors: Giraldo María Paula , Beltrán Andrés Guillermo , Díaz-Ramírez Julieth , Franco-Gruntorad German Andrés 
Published: December 2023

Introduction: The minimum number of procedures required to be performed during anesthesia training has not been officially defined in Colombia. Although a number is no guarantee of acquired competencies, it does indicate the level of opportunity offered by the different programs. This study describes the practical training afforded to residents in a graduate anesthesia program in Colombia, and compares its results with international standards.
Objective: Describe exposure to procedures performed by residents enrolled in a three-year anesthesia specialization program in Colombia between 2015 and 2020, and compare with the standards proposed by ASCOFAME and ACGME.
Methods: Descriptive, cross-sectional study which included residents who did their specialization in a Colombian anesthesia program between 2015 and 2020. Complexity, anesthesia techniques, invasive monitoring and airway approach were described. Finally a descriptive comparison was made with the published references of the Colombian Association of Medical Schools (ASCOFAME) and the Accreditation Council for Graduate Medical Education (ACGME).
Results: The results for 10 residents were included. Each resident had a median of 978 cases (IQR 942-1120), corresponding to 25 surgical specialties, the most frequent being general surgery (18%), orthopedics (16%), pediatric surgery (19%), and obstetrics (10.8%). According to the American Society of Anesthesiology (ASA) classification, the majority of patients were ASA II (39.63%) and ASA III (28.4%). Adequate exposure was achieved in 11 of the 15 categories proposed by ACGME and in 6 of the 15 proposed by ASCOFAME.
Conclusions: A detailed description of the practice component acquired by the residents during their three years of training was obtained. This baseline provides insight into the national landscape and allows to describe the relationship with international standards.
DNA barcoding of Tribolium castaneum (Coleoptera: Tenebrionidae) from selected states in Nigeria based on mitochondrial DNA sequences
Authors: IYIOLA Oluyinka A. , ODUOLA Adedayo O. , ADEREMI Rahmat D. , ADELAJA Olukayode J. , LATEEF Adebola A. , ALABA Ademola E. , ADEJUWON Seun F. , FULANI Aliu S. 
Published: December 2023

Tribolium castaneum also known as red flour beetle is one of the most important pests of stored grain product with a cosmopolitan distribution in Nigeria and all over the world contributing to food spoilage. The aim of this study was to characterize the T. castaneum by morphometric and molecular analyses. Samples of yam flour with evidence of the red flour beetles present inside were obtained from four locations in Kwara, Kogi, Oyo and Ekiti states in Nigeria. Morphological and molecular identifications of T. castaneum were carried out using standard methods. A dissecting microscope was used to identify the beetles and measurements were taken using ImageJ. Genomic DNA was extracted and checked on 1.5% agarose gel to confirm the presence of DNA. Species-specific primers were used to amplify mitochondrial cytochrome oxidase I (COI) gene of T. castaneum and the PCR amplicon size was also checked on 1.5% agarose. Morphometric measurements showed that the highest mean number (33.00±4.24 mm) of T. castaneum larvae observed was recorded on day 61 in Ilorin and the lowest was in Iwo, Osun state (4.00±0.00 mm) on the same day. The mean of the total body length of larvae from sampling sites was (1.31±0.37 mm) with minimum and (1.63±1.14 mm) maximum lengths respectively. There was no significant difference (p>0.05) between the mean length of the larvae collected from the study locations. Aligned cytochrome oxidase subunit 1 (COI) sequences of 313bp were analyzed. Phylogenetic analysis inferred by maximum likelihood method showed that the T. castaneum sequences analyzed for this study and sequences obtained from GenBank formed a monophyletic group. The molecular and phylogenetic analyses confirmed the presence of a single species of T. castaneum. The results from this study showed low levels of genetic diversity and variability in the studied T. castaneum populations. The observed genetic similarity in T. castaneum could be due to the fact that they were probably from similar origin when compared with those in the GenBank database. However, further studies are needed with more samples to characterize T. castaneum species from stored food grains across Nigeria.
Relações interpessoais e violência: análise dos discursos de ódio
Authors: De Andrade Joyce Karolyne Ribeiro , Maniakas Georgina Carolina de Oliveira Faneco 
Published: December 2023

Este estudo objetivou investigar os elementos psicossociais envolvidos na propagação dos discursos de ódio através da perspectiva freudiana da cultura. O corpus selecionado foi o de 9 comentários ofensivos publicados no Facebook acerca de 3 diferentes notícias envolvendo a violação de direitos humanos. Os discursos de ódio são construídos a partir de generalizações sobre grupos sociais específicos. A cultura projeta sobre os indivíduos normas e valores provenientes de determinados momentos históricos e formações ideológicas; então, ao acreditarem expor um ponto de vista particular, apenas o estão reproduzindo. A disseminação dos discursos não necessariamente indica que atualmente exista mais intolerância ou preconceitos contra grupos sociais minoritários, pois estes sempre constituíram parte da estrutura social. A sociedade passa por um momento histórico em que determinados conteúdos, outrora reprimidos, podem, por meio da internet, aparecer sob a forma de discursos de ódio.
The Conception of Environmental Sovereignty for The Discovery of Just Law in The Field of Environment in Indonesia
Authors: Nasrullah  , Rahmat  
Published: December 2023

Purpose: The purpose of this research is to analyze the conception of environmental sovereignty for the discovery of just law in the field of environment in Indonesia and analyze the Implementation of the Concept of Environmental Sovereignty in Legislation in the Field of Environment and Natural Resources.

Theoretical reference: The theoretical framework for this research will draw upon concepts of environmental sovereignty, legal pluralism, socio-ecological systems theory, environmental justice, international environmental law, and indigenous rights. It will also integrate perspectives from scholars specializing in environmental law, policy studies, anthropology, and environmental ethics.

Method: The method of approach used in the research is a normative approach in this case analyze, the level of legal synchronization both vertically and horizontally related to environmental sovereignty for the discovery of fair law in the field of environment.

Results and Conclusion: The results of this research show that The conception of environmental sovereignty for the discovery of just law in the field of environment in Indonesia is to form a harmonious, just, democratic and sustainable environmental law, then the conception of environmental sovereignty in the sense of creating a balance of rights between humans and nature, with a legal pluralism approach to realizing environmental justice and the Implementation of the Concept of Environmental Sovereignty in Legislation in the Field of Environment and Natural Resources is to form norms in laws and regulations governing the management of natural resources and the environment.

Implications of research: The research findings will have significant implications for policymakers, environmental organizations, indigenous communities, and scholars working in the field of environmental law and policy. It will provide insights into the strengths and weaknesses of current legal frameworks, offer recommendations for enhancing environmental governance, and suggest ways to balance sovereignty with global environmental responsibilities.

Originality/Value: This research contributes to the existing body of knowledge by providing a comprehensive analysis of the interplay between environmental sovereignty and the development of just laws in Indonesia. It offers original insights into how the concept of sovereignty influences environmental decision-making and its impact on environmental justice, policy implementation, and sustainable development in a diverse and ecologically rich country like Indonesia.
Simbol Gunung dan Air pada Lanskap Budaya Situs Candi Agung di Kalimantan Selatan
Authors: Hindarto Imam , Kusmartono Vida Pervaya Rusianti , Wahyu  
Published: December 2023

The Candi Agung site is one of the cultural landscapes in South Kalimantan. The value of this cultural landscape is closely related to living traditions, belief systems, art and literature. This cultural landscape also represents the symbols of mountains and water in the culture of the Banjar people. These two physical-naturalistic components not only describe the landscape of South Kalimantan which consists of the Meratus Mountains and the Barito River but also describe the cultural landscape of the people who inhabited it. This study discusses the meaning of mountains and water in the cultural landscape of the Candi Agung Site. The aim is to understand the Candi Agung Site as an associative cultural landscape in Banjar culture. In order to understand this, data collection was carried out through observations of the Candi Agung Site and the views of the surrounding community. A documentation study on the Lambung Mangkurat Museum collection was carried out to complete the observation data. The analysis was carried out by describing aspects of mountain and water symbolism in the Lambu Mangkurat Story and the Banjar Kings Dynasty and Waringin City or known as the Banjar Hikayat. Apart from that, descriptions were also made of literary works entitled Tutur Candi. The interpretive framework of this study refers to the view that culture is a symbol system. This study produces an understanding of the cultural system of the Banjar people which was represented in the myth of the sacredness of mountains and water. These two natural elements are representations of supernatural forces which were manifested in the toponymy "mountain" of Candi Agung and the anthroponymy of Tunjung Buih. The connection between the two also represents harmony between the microcosm and the macrocosm.

Key words: Environment, cultural landscape, microcosm, dualism
Döviz Piyasası Baskı Endeksi ile Kur Krizi Dönemlerinde Tepki Veren Sanayi Şehirlerinin Elektrik Tüketim Miktarı ile Belirlenmesi
Authors: TARKUN Savaş 
Published: December 2023

Öz
Sinyal yaklaşımında, bir değişkenin olası bir ekonomik krizden önceki dönemde belirli bir eşik değerinin üzerine çıkması durumunda krizin meydana gelebileceği konusunda erken uyarı sinyali verdiği düşünülmektedir. Bu çalışmada, Kaminsky ve Reinhart (1999) tarafından geliştirilen döviz piyasası baskı endeksini, elektrik tüketim miktarı ile incelenmesi amaçlanmaktadır. Bu doğrultuda, ISO 500 tarafından 2021 yılı için belirlenmiş olan Türkiye’nin sanayi şehirleri Ocak 2016-Ağustos 2022 dönemi için araştırılmıştır. Sonuçlara göre Model-1 de bulunan 9 şehirden, döviz piyasası baskı endeksinin eşik değeri geçtiği dönemlerde istatistiksel olarak anlamlı bulunan sanayi şehirleri sırası ile Ankara, Bursa ve Manisa’dır. Model-2 de bulunan 8 şehirden sadece Konya ve Model-3 de bulunan 12 şehirden Eskişehir, Karabük ve Osmaniye istatistiksel olarak anlamlı bulunmuştur. Birlikte incelenen model sonuçlarına göre ise Ankara, Karabük ve Manisa şehirlerindeki sanayilerin kriz dönemlerinde sinyal veren şehirler olarak tespit edilmiştir.
Analisis Modal Kerja dalam Meningkatkan Profitabilitas Perusahaan Pada PT. Indocement Tunggal Prakarsa, Tbk
Authors: Sulkipli Sulkipli , Gunawan Hendra , Sudirman Firda Sulistya 
Published: December 2023

Penelitian ini bertujuan untuk menganalisis modal kerja dalam meningkatkan profitabilitas pada PT. Indocement Tunggal Prakarsa, Tbk. Metode analisis yang digunakan dalam penelitian ini yaitu metode analisis deskriptif kuantitatif menggunakan data sekunder. Alat analisis yang digunakan dalam penelitian ini adalah analisis modal kerja, analisis rasio profitabilitas yang terdiri dari Net Profit Margin, Gross Profit Margin, Return On Assets, Return On Equity. Hasil penelitian ini menunjukkan bahwa modal kerja pada PT. Indocement Tunggal Prakarsa, Tbk pada periode 2018-2020 mengalami fluktuasi. Dimana modal kerja tahun 2018-2019 mengalami peningkatan 7,85% atau sebesar Rp. 531.855.000.000, peningkatan modal kerja dikuti dengan peningkatan Net Profit Margin, Gross Profit Margin, Return On Asset, Return On Equity. Dan pada periode 2019-2020 modal kerja mengalami penurunan 9,39% atau sebesar Rp. 838.652.000.000, penurunan modal kerja diikuti oleh penurunan pada Return On Assets namun Net Profit Margin, Gross Profit Margin, dan Return On Equity mengalami peningkatan pada periode 2019-2020.
SPECIAL ASPECTS OF THE PAIN SYNDROME TREATMENT METHODS IN REHABILITATION PRACTICE
Authors: Давыдов А.Т. , Бутко Д.Ю. , Гришаев С.Л. , Даниленко Л.А. , Калинина М.В. , Калинин А.В. , Вышегородцева З.И. 
Published: December 2023

В обзоре с современных позиций излагаются значение, роль и место медикаментозных и немедикаментозных методов лечения болевого синдрома в реабилитационной практике. Даны классификации и рассмотрены основные методы лечения болевого синдрома. Показано, что оптимальный выбор терапии лечения болевого синдрома существенно влияет на успешность проведения реабилитационных мероприятий.
The review outlines the significance, role and place of drug and non-drug methods of pain syndrome treatment in rehabilitation practice from modern positions. Classifications are given and the main drug and non-drug methods of pain syndrome treatment are examined. It is shown that the optimal choice of drug and non-drug methods of pain syndrome treatment has a significantly effect on the success of rehabilitation measures.
Evaluation du profil d’acide gras et statuts d’oxydation de sept huiles alimentaires commercialisées au Bénin
Authors: Agbokponto J. E. , Idé A. , Warnant A. , Yemoa L. Y. A. , Quetin-Leclercq J. , Larondelle Y. 
Published: December 2023

Introduction : Les populations béninoises consomment au quotidien des huiles végétales de différent profil d’acides gras (AG) insaturés comme saturés, leur conférant des vitesses d’oxydabilité différentes. Les produits d’oxydation primaire (radicaux peroxydes) et secondaire (aldéhydes) sont nuisibles à la santé humaine et justifient la nécessité d’une évaluation de ces huiles alimentaires.
Méthodologie : Cette étude préliminaire porte sur 7 marques d’huile dont 1 de tournesol, 2 de coton et 2 d’origine végétale non précisée, toutes raffinées, ainsi que 1 d'arachide et 1 de palme rouge de production artisanale locale. Le profil d’AG a été réalisé, après méthylation des AG, au moyen d’un GC-FID Trace 1310 (Thermo, Italy), équipé d’un Triplus autosampler (Thermo, Italy). La séparation a été réalisée sur une colonne capillaire RT2560 (100m x 0,25mm, df : 0,25µm) avec une injection de 1 µL on-column à 225°C. Le temps d’analyse est de 83 min avec un gradient de température du four allant de 80-235°C. Le H2 est utilisé comme gaz vecteur à 1,2 ml/min. L’oxydation primaire et secondaire ont été déterminées par l’indice de peroxyde (IP) et l’indice de p-anisidine (Ip-A) selon la méthode AOCS.
Résultats et Discussion : L’analyse des résultats rapporte les données suivantes :
L’huile de tournesol contient 60% d’acide linoléique (AL), 29% d’acide oléique (AO) ; le coton 54% d’AL, 17% d’AO et 24% d’acide palmitique (AP) contre 33%, 43% et 13% respectivement pour l’huile d'arachide. Le profil d’AG des 02 huiles raffinées et de l’huile de palme rouge est similaire avec 40- 41% d’AP et 41-46% d’AO.
Les 02 marques d’huile de coton et 01 de tournesol présentent une forte oxydation primaire avec des valeurs de IP de 16; 25 et 28,9 méq O2 actif/kg (norme < 15). Les huiles d’arachide (IP=3), de palme (IP=6,6) et les 2 huiles végétales raffinées (IP= 10,35 et 12,38) sont conformes. Quant à l’oxydation secondaire, toutes les huiles analysée sont conformes, 0≤.Ip-A≤ 6,21 (norme < 10) après 6 semaines de conservation dans les conditions classiques (fermeture non scellée).
Conclusion : Cette étude préliminaire révèle que les huiles de coton et de tournesol subissent une oxydation rapide comparée aux huiles d’arachide et de palme. Des huiles de palme blanchies sans étiquetage adéquate sont commercialisées et tromperaient la vigilance des populations.
Determination of the phytochemical profile and anti-oxidant capacity of the roots of Beta vulgaris (Chenopodiaceae)
Authors: Obono FMP , Betote DHP , Soppo LV , Benga MF , Ngolsou F , Maniepi FJS , Nko’o MJ , Nzie Maniben , Nga Nnanga , Ze Minkande J 
Published: December 2023

Introduction: Chronic inflammation due to oxidative stress plays an essential role in the pathogenesis of chronic diseases like cardiovascular diseases. Regular consumption of fruits/vegetables known as medicinal plants are considered as fundamental approach in treating non communicable diseases like hypertension. These is achieved through secondary metabolites contained in the above-mentioned plants.
Objective: To determine the phytochemical profile and anti-oxidant capacity of the roots of Beta vulgaris (Chenopodiaceae).
Methodology: Qualitative phytochemical analysis was carried out according to Harbone and Evans principles. Total polyphenol content was assessed according to Li et al, total flavonoid content was assessed according to Zhishen et al and total tannins content was measured according to Julkumen-Titto. Antioxidant capacity were performed in vitro using the DPPH tests (radical scavenging) according to Blois and Ferric Reducing Ability of Plasma (FRAP) according to Benzie and strain. All tests were performed in triplicates at 1500μg/mL. The type of antioxidant ability (primary or secondary) was assessed.
Results: The phytochemical analysis of the raw root of Beta vulgaris revealed the presence of polyphenols, flavonoids, alkaloids and terpenes. Total polyphenol, flavonoids and tannins content was 18,56±1,0, 31,19±3,12 572,84±54 mg of catechin, quercetin and tannic acid equivalent/gram dry matter respectively. Antioxidant tests revealed radical scavenging activity with DPPH whose SC50 was 108.2
μg/mL against 302.5 μg/mL for gallic acid and FRAP (chelating antioxidant) activity at 1089.14±99.23 mg catechin equivalent per gram of dry matter. The antioxidant ability was secondary (preventive).
Conclusion: Beta vulgaris possess the three main group of secondary metabolites and secondary antioxidant activity.
Effets de l’extrait aqueux des feuilles de Solanum torvum sw (solanaceae) sur quelques altérations des fonctions hépatique et rénale induite par la gentamicine
Authors: MEWOLI BEKONO E M , FOUTSE YIMTA W , NGUEGUIM F , DJIENTCHEU J-P , NGUIMATSIA F , DIMO T 
Published: December 2023

Introduction : Les atteintes hépatiques et rénales sont des altérations des fonctions du foie et des reins. 50 % de ces altérations seraient d’origine médicamenteuse. La prise en charge étant onéreuse, motive les personnes affectées à s’orienter vers la phytothérapie comme traitements alternatifs. Cette étude avait pour objectif l’évaluation des effets de l’extrait aqueux des feuilles de Solanum torvum sur quelques altérations des fonctions hépatique et rénale induite par la gentamicine.
Matériel et Méthodes : Soixante rats ont été utilisés, divisés en trois lots, ils recevaient pendant 10 jours en dose quotidienne la gentamicine 100 mg/kg (i.p) pour les rats du lot 1 (n=45), le NaCl (0,9 %, i.p) pour le lot 2 (n=10) et l’extrait à la dose 530 mg/kg (p.o) pour le lot 3 (n=5). Au 11e jour, les rats du lot 1 ont été répartis en 05 groupes (n=9) et traités pendant 10 jours en dose quotidienne avec de l’ED (10 mL/kg, p.o) pour témoin négatif, la silymarine (150 mg/kg, p.o) pour le témoin positif et l’extrait aux doses 133, 265 et 530 mg/kg (p.o) pour les groupes tests ; le traitement du lot 2 (témoin normal) et
3 (témoin pharmacologique) était maintenus. Les analyses de quelques paramètres biochimiques sériques hépatiques (transaminases, PAL, γ-GT, albumine, protéines sériques et bilirubines), rénaux (créatinine sérique et Acide urique sérique) et tissulaires (statut oxydant et microarchitecture) ont été réalisés.
Résultats et discussion : La gentamicine a provoqué au bout de 20 jours une baisse significative du poids corporel, une baisse de l’activité de la PAL, du taux d’albumine et une augmentation significative du poids des reins, de l’activité des transaminases et de la γ-GT. L’administration de l’extrait a significativement corrigé (p< 0,001) les troubles de la fonction hépatique en restaurant l’activité des transaminases, de la γ-GT et de la PAL, en améliorant les désordres du profil de bilirubine et de l’albumine. L’extrait a prévenu et corrigé l’augmentation du taux d’acide urique et de créatinine sérique. Il a été observé une amélioration du statut oxydant accompagné d’une restauration de la microarchitecture des tissus hépatique et rénale comparé au témoin normal.
Conclusion : Les effets pharmacologiques de l’extrait prouvent qu’il posséderait des propriétés hépatoprotectrices et néphroprotectrices qui pourrait nous pousser à envisager la mise sur pied d’un médicament traditionnel amélioré.