bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone
Authors: Toya Masakazu , Kushioka Junichi , Shen Huaishuang , Utsunomiya Takeshi , Hirata Hirohito , Tsubosaka Masanori , Gao Qi , Chow Simon K-H. , Zhang Ning , Goodman Stuart B. 
Published: January 2024

AimsTranscription factor nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of chronic inflammatory diseases in all organ systems. Despite its importance, NF-κB targeted drug therapy to mitigate chronic inflammation has had limited success in preclinical studies. We hypothesized that sex differences affect the response to NF-κB treatment during chronic inflammation in bone. This study investigated the therapeutic effects of NF-κB decoy oligodeoxynucleotides (ODN) during chronic inflammation in male and female mice.MethodsWe used a murine model of chronic inflammation induced by continuous intramedullary delivery of lipopolysaccharide-contaminated polyethylene particles (cPE) using an osmotic pump. Specimens were evaluated using micro-CT and histomorphometric analyses. Sex-specific osteogenic and osteoclastic differentiation potentials were also investigated in vitro, including alkaline phosphatase, Alizarin Red, tartrate-resistant acid phosphatase staining, and gene expression using reverse transcription polymerase chain reaction (RT-PCR).ResultsLocal delivery of NF-κB decoy ODN in vivo increased osteogenesis in males, but not females, in the presence of chronic inflammation induced by cPE. Bone resorption activity was decreased in both sexes. In vitro osteogenic and osteoclastic differentiation assays during inflammatory conditions did not reveal differences among the groups. Receptor activator of nuclear factor kappa Β ligand (Rankl) gene expression by osteoblasts was significantly decreased only in males when treated with ODN.ConclusionWe demonstrated that NF-κB decoy ODN increased osteogenesis in male mice and decreased bone resorption activity in both sexes in preclinical models of chronic inflammation. NF-κB signalling could be a therapeutic target for chronic inflammatory diseases involving bone, especially in males.Cite this article: Bone Joint Res 2024;13(1):28–39.
Contacto, cambio multifactorial y dinámico en la zona andina: epistemicidad encubierta en construcciones con DECIR
Authors: Soto Rodríguez Mario , Dankel Philipp 
Published: January 2024

El empleo de la construcción interrogativa ¿qué diciendo? en la región andina ha llamado la atención de diferentes autores por su singularidad. Considerado como un interrogativo de causa, se asume que el empleo se debe a un calco sintáctico del quechua. No obstante, los datos sugieren diferentes empleos formados en base a DECIR empleado con valores modales-epistémicos.
En esta contribución revisamos los empleos de la combinación decir + gerundio y su equivalente quechua niy + -spa en diferentes contextos sintácticos y funcionales en base a datos de la región andina. Los resultados dan cuenta de la confluencia de varios factores en los empleos de decir como recurso epistémico cognitivo y de procesos de gramaticalización del gerundio hacia empleos justificativos con carácter epistémico bajo el esquema cuotativo.
Human-animal relationships, silliness, and queer homemaking in Sven Nordqvist’s Pettson and Findus
Authors: Rosenberg-Meereboer Arwen 
Published: January 2024

This article argues that the picture book series Pettson and Findus by Sven Nordqvist can be a valuable resource when looking at ethics of matter and thinking through relationships with the more-than-human. Pettson and Findus is a series of picture books written and illustrated by Sven Nordqvist. The books depict the relationship between old man Pettson and his cat Findus, who live in an old farmhouse in the south of Sweden together with chickens, invisible “muckles” and a variety of other creatures and people. The books centre on relatively mundane activities, made into small adventures by the various different creatures. This article analyses the Pettson and Findus series through Donna Haraway’s analysis of human animal relationships in When Species Meet (2008) and calls for the making of oddkin in Staying with the Trouble (2016). This article, using Will McKeithen’s analysis in Queer Ecologies of the Home and Monica Flegel’s Pets and domesticity in Victorian culture, argues that Pettson and Findus live in a queer kind of household, and participate in queer home making. Using Jack Halberstam’s analysis in The Queer Art of Failure (2011) this article centres Pettson as a figure that is both queer and silly, and through this queer silliness creates certain openings for queer community with the more-than-human, and the making of oddkin.
Effects of two gait retraining programs on pain, function, and lower limb kinematics in runners with patellofemoral pain: A randomized controlled trial
Authors: de Souza Júnior José Roberto , Rabelo Pedro Henrique Reis , Lemos Thiago Vilela , Esculier Jean-Francois , Barbosa Glauber Marques Paraizo , Matheus João Paulo Chieregato 
Published: January 2024

Background
Patellofemoral Pain (PFP) is one of the main injuries in runners. Consistent evidence support strengthening programs to modulate symptoms, however, few studies investigated the effects of gait retraining programs.

Objective
To investigate the effects of two different two-week partially supervised gait retraining programs on pain, function, and lower limb kinematics of runners with PFP.

Methods
Randomized controlled trial. Thirty runners were allocated to gait retraining groups focusing on impact (n = 10) or cadence (n = 10), or to a control group (n = 10). Impact group received guidance to reduce tibial acceleration by 50%, while cadence group was asked to increase cadence by 7.5–10%. The control group did not receive any intervention. Usual and running pain, knee function, and lower limb kinematics (contralateral pelvic drop, hip adduction, knee flexion, ankle dorsiflexion, tibia inclination, and foot inclination) were evaluated before (T0), immediately after the intervention (T2), and six months after the protocol (T24).

Results
A significant group x time interaction was found for running pain (p = 0.010) and knee function (p = 0.019). Both programs had greater improvements in running pain compared to no intervention at T24 (Impact x Control—mean difference (MD) −3.2, 95% CI −5.1 to −1.3, p = 0.001; Cadence x Control—MD −2.9, 95% CI −4.8 to −1.0, p = 0.002). Participants of the impact group had greater improvements in knee function compared to no intervention at T2 (Impact x Control–MD 10.8, 95% CI 1.0 to 20.6, p = 0.027). No between-group differences in usual pain and lower limb kinematics were found (p>0.05).

Conclusion
Compared to no intervention, both programs were more effective in improving running pain six months after the protocol. The program focused on impact was more effective in improving knee function immediately after the intervention.
Clinical trial registry number: RBR-8yb47v
Effects of MDMA-assisted therapy for PTSD on self-experience
Authors: van der Kolk Bessel A. , Wang Julie B. , Yehuda Rachel , Bedrosian Leah , Coker Allison R. , Harrison Charlotte , Mithoefer Michael , Yazar-Klosinki Berra , Emerson Amy , Doblin Rick 
Published: January 2024

Introduction
There is a resurgence of interest in the therapeutic potential of psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA). Primary findings from our randomized, double-blind, placebo-controlled, multi-site Phase 3 clinical trial of participants with severe PTSD (NCT03537014) showed that MDMA-assisted therapy induced significant attenuation in the Clinician-Administered PTSD Scale for DSM-5 compared to Therapy with placebo. Deficits in emotional coping skills and altered self-capacities constitute major obstacles to successful completion of available treatments. The current analysis evaluated the differential effects of MDMA-assisted therapy and Therapy with placebo on 3 transdiagnostic outcome measures and explored the contribution of changes in self-experience to improvement in PTSD scores.

Methods
Participants were randomized to receive manualized therapy with either MDMA or placebo during 3 experimental sessions in combination with 3 preparation and 9 integration therapy visits. Symptoms were measured at baseline and 2 months after the last experimental session using the 20-item Toronto Alexithymia Scale (TAS-20), the 26-item Self Compassion Scale (SCS), and the 63-item Inventory of Altered Self-Capacities (IASC).

Results
90 participants were randomized and dosed (MDMA-assisted therapy, n = 46; Therapy with placebo, n = 44); 84.4% (76/90) had histories of developmental trauma, and 87.8% (79/90) had suffered multiple traumas. MDMA-assisted therapy facilitated statistically significant greater improvement on the TAS-20, the SCS, and most IASC factors of interpersonal conflicts; idealization disillusionment; abandonment concerns; identity impairment; self-awareness; susceptibility to influence; affect dysregulation; affect instability; affect skill deficit; tension reduction activities; the only exception was identity diffusion.

Conclusion
Compared with Therapy with placebo, MDMA-assisted therapy had significant positive effects on transdiagnostic mental processes of self-experience which are often associated with poor treatment outcome. This provides a possible window into understanding the psychological capacities facilitated by psychedelic agents that may result in significant improvements in PTSD symptomatology.
Dietary quality and cardiometabolic indicators in the USA: A comparison of the Planetary Health Diet Index, Healthy Eating Index-2015, and Dietary Approaches to Stop Hypertension
Authors: Frank Sarah M. , Jaacks Lindsay M. , Avery Christy L. , Adair Linda S. , Meyer Katie , Rose Donald , Taillie Lindsey Smith 
Published: January 2024

Background
The Planetary Health Diet Index (PHDI) measures adherence to the sustainable dietary guidance proposed by the EAT-Lancet Commission on Food, Planet, Health. To justify incorporating sustainable dietary guidance such as the PHDI in the US, the index needs to be compared to health-focused dietary recommendations already in use. The objectives of this study were to compare the how the Planetary Health Diet Index (PHDI), the Healthy Eating Index-2015 (HEI-2015) and Dietary Approaches to Stop Hypertension (DASH) relate to cardiometabolic risk factors.

Methods and findings
Participants from the National Health and Nutrition Examination Survey (2015–2018) were assigned a score for each dietary index. We examined disparities in dietary quality for each index. We used linear and logistic regression to assess the association of standardized dietary index values with waist circumference, blood pressure, HDL-C, fasting plasma glucose (FPG) and triglycerides (TG). We also dichotomized the cardiometabolic indicators using the cutoffs for the Metabolic Syndrome and used logistic regression to assess the relationship of the standardized dietary index values with binary cardiometabolic risk factors. We observed diet quality disparities for populations that were Black, Hispanic, low-income, and low-education. Higher diet quality was associated with improved continuous and binary cardiometabolic risk factors, although higher PHDI was not associated with high FPG and was the only index associated with lower TG. These patterns remained consistent in sensitivity analyses.

Conclusions
Sustainability-focused dietary recommendations such as the PHDI have similar cross-sectional associations with cardiometabolic risk as HEI-2015 or DASH. Health-focused dietary guidelines such as the forthcoming 2025–2030 Dietary Guidelines for Americans can consider the environmental impact of diet and still promote cardiometabolic health.
Subsídios para a estruturação da história dos acontecimentos ocorridos no distrito do Congo (Uíge) - Volume I: Intendente Custódio Ramos Para O Ministério do Ultramar
Authors: Ramos Custódio 
Published: January 2024

Em Março de 1961 Custódio Abel Fernandes Ramos – administrador do concelho de Carmona (Uíge) – testemunhou no terreno o início da luta armada pela independência de Angola. Incumbido de narrar os acontecimentos pelo então Ministro do Ultramar, Adriano Moreira, Custódio Ramos produziu um minucioso relatório constituído por mais de mil páginas de informação sobre os primeiros meses da insurreição nacionalista promovida pela União dos Povos de Angola (UPA) no Noroeste de Angola. Nesse relatório, Custódio Ramos não só documentou com grande diligência os factos relativos à eclosão da luta armada, mas procurou também interpretá-los em termos político-ideológicos, no contexto da Guerra Fria, utilizando para o efeito os métodos analíticos e discursivos próprios do Estado Novo. Neste sentido, o relatório, ora publicado em edição fac-similada, constitui uma fonte documental preciosa e extremamente relevante não só para a reconstituição dos factos históricos em si, mas também para a compreensão do pensamento e da reação da administração colonial portuguesa no primeiro ano de guerra em Angola.
Efficacy and safety of glucagon-like peptide-1 receptor agonists therapy initiation in patients with type 2 diabetes hospitalized with coronavirus infection
Authors: Markova T. N. , Lysenko M. A. , Stas M. S. , Anchutina A. A. 
Published: January 2024

BACKGROUND. The search for new effective methods of treatment and prevention of COVID-19 in patients with type 2 diabetes mellitus (T2DM) remains an urgent task for the healthcare system.AIM. To evaluate the efficacy and safety of initiating of glucagon-like peptide-1 receptor agonists (GLP-1RA) therapy in T2DM patients hospitalized with COVID-19.MATERIALS AND METHODS. The inclusion criteria were history of T2DM, BMI> 27 kg/m2, confirmed diagnosis of COVID-19. The intervention group of 53 patients started dulaglutide therapy (1,5 mg once weekly) during the first 24 hours of admission, the control group consisted of 50 patients, who proceeded with glucose-lowering therapy. We evaluated the effect of therapy on carbohydrate metabolism, laboratory and clinical parameters, the outcome of COVID-19 and the safety of therapy (hypoglycemic events, side effects).RESULTS. There were no differences found in the degree of decrease in the level of glycemia in the compared groups: fasting plasma glucose (FPG) on day 7 of hospitalization– 8,2 [6,0;9,8] mmol/L vs 8,1 [6,5;9,8] mmol/L (p=0,935), mean daily glycemia (MDG) — 9,7 [8,3;11,8] mmol/L vs 11,1 [8,7;12,8] mmol/L (p=0,182). Therapy of dulaglutide had a positive effect on inflammatory markers: CRP (15,8 vs 24,4 mg/l, p=0,035), LDH (261,6 vs 326,1 U/l, p=0,016) and the level of lymphocytes (1,2 vs 0,9 x 10*9/L, p=0,049) and on clinical parameters: saturation, the need for oxygen therapy and the risk of severe course according to the NEWS2 scale. The death rate in the group receiving GLP-1RA is 3,5 times lower compared to the control group (5,7% vs 20,0%, p=0,038). The initiation of dulaglutide therapy in patients with T2DM hospitalized with COVID-19 reduced the chance of death and transfer to mechanical ventilation by 4,2 times compared to the control group (OR = 0,24, 95% CI: 0,062–0,931). GLP-1RA therapy in patients with COVID-19 and T2DM is safe in terms of hypoglycemic events and side effects.CONCLUSIONS. The initiation of GLP-1RA therapy leads to a decrease in FPG and MDG, comparable with the control group. The start of GLP-1RA therapy in hospitalized patients with COVID-19 and T2DM reduces the chance of death, favorably affecting on laboratory and clinical parameters.
Humoral factors in the formation of neuroosteoarthropathy in type 2 diabetes mellitus
Authors: Kalandiya M. M. , Kogan E. A. , Nikankina L. V. , Tokmakova A. Y. , Zaitseva E. L. , Galstyan G. R. 
Published: January 2024

BACKGROUND: Diabetic neuroosteoarthropathy is a severe and insufficiently studied complication of diabetes mellitus, which is characterized by progressive destruction of bones and joints against the background of neuropathy and leads to the formation of foot deformities of varying severity. The search for predictors of this pathology is extremely relevant, because will optimize therapy and reduce the risk of limb amputation.AIM: To compare the levels of advanced glycation end products and their receptors in the blood and bone tissue in patients with type 2 diabetes mellitus and diabetic neuroosteoarthropathy and in individuals without this complication in order to determine the possibility of using these parameters as early predictors of severe foot deformities in this category of patients.MATERIALS AND METHODS: During hospitalization for planned surgical treatment, venous blood and bone tissue samples were taken from patients with chronic (inactive) stage of DNOAP and patients with neuropathic foot ulcers.RESULTS: The study included 88 patients with type 2 diabetes mellitus and neuropathic form of diabetic foot syndrome, who were divided into 2 groups. Group 1 consisted of patients with chronic diabetic neuroosteoarthropathy, group 2 — patients with severe diabetic neuropathy without osteoarticular disorders. The study did not show statistically significant differences in the level of AGE in the blood serum of patients with DNOAP and without this complication, however, a significant increase in AGE receptors (RAGE) in bone tissue was recorded in the group of patients with DNOAP compared with the control. Patients with increased RAGE expression in bone had higher blood levels of AGE compared to the group without this complication, but this difference was not significant.CONCLUSION: For the first time, a study of AGEs and receptors for them in the blood serum and bone tissue in individuals with DNOAP and without this complication was carried out. The obtained results suggest that the determining factor in the rate of formation and the likelihood of recurrence of DNOAP in type 2 diabetes mellitus is not the content of AGEs in the blood, but the expression of their receptors in bone tissue.
Gambaran Lifestyle Behavior, Strategi Koping dan Subjective Well-being Remaja Selama Pandemi Covid-19 di Kota Banda Aceh
Authors: Hidayati Rahma , Asniar Asniar , Rachmalia Rachmalia 
Published: January 2024

Introduction: Adaptation to new situations caused by the Covid-19 pandemic limits adolescents' spaces in performing daily routines. This limitation also impacts their subjective well-being. Subjective well-being relates to lifestyle behavior and coping strategies. Therefore it is essential to assess in defining appropriate nursing interventions for adolescents. This study aimed to describe lifestyle behavior, coping strategies, and subjective well-being during the Covid-19 pandemic in Banda Aceh City. Methods: This study employed a descriptive exploratory design with a cross-sectional approach, involving 168 adolescents selected by snowball sampling. Data was collected by using a self-report questionnaire distributed by google form.Results: The study findings show that most of the adolescents tried to obey the regulations during the Covid-19 pandemic (63.1%); few of the respondents planned their daily routines (19.0%); were involved in different activities (10.7%), and only a few who do physical activity regularly (21.4%). Adolescents often shared their feelings (31.5%) and reviewed their relationships with their families (38.7-42.3%). In terms of social and school interactions, adolescents maintained contact with their friends and teachers (35.1-43.5%). The adolescents maintained school obligations at home (49.4%), and this period did not affect their educational path (50.0%). In addition, most adolescents reported slight changes in subjective well-being (41.1%) and mild anxiety (38.1%). Discussion/Suggestion: This study highlights several conditions that need consideration from relevant stakeholders, including community health nurses or school health nurses, in designing interventions to prevent poor lifestyle behaviors and improve adolescents' adaptive coping and subjective well-being. Consequently, nurses should collaborate with families, school boards, public health centers, district health offices, and other government sectors in implementing health promotion programs for adolescents during the Covid-19 pandemic, particularly in improving lifestyle behaviors, adaptive coping, and subjective well-being.
Studi Kasus: Penerapan Pursed Lip Breathing dan Diaphragmatic Breathing Exercise pada Pasien Congestive Heart Failure dengan Sesak Napas di Instalasi Gawat Darurat
Authors: Febyastuti Isna widya , Widyaningtyas Nur Hafizhah , Zakaria Eka Dafid 
Published: January 2024

Sesak napas pada pasien Congestive Heart Failure (CHF) terjadi karena ventrikel kiri tidak mampu memompa darah yang datang dari paru – paru sehingga cairan terdorong ke jaringan paru. Selain itu, sesak napas disebabkan karena jantung tidak dapat memompa darah ke seluruh tubuh secara maskimal sehingga suplai oksigen didalam tubuh tidak adekuat yang akan berpengaruh pada sel - sel dan organ dalam tubuh mengalami kekurangan asupan oksigen. Pursed Lip Breathing (PLB) dan Diaphragmatic Breathing Exercise (DBE) merupakan intervensi non farmakologi yang dapat menurunkan sesak napas pasien CHF. Studi ini bertujuan untuk mengetahui hasil penerapan kombinasi PLB dan DBE terhadap frekuensi napas, saturasi oksigen dan skala sesak napas pada pasien CHF. Studi ini menggunakan metode studi kasus dengan pengumpulan data dilakukan pengukuran frekuensi napas, saturasi oksigen, dan skala sesak napas dilakukan sebelum dan sesudah intervensi. Intervensi kombinasi PLB dan DBE yang dilakukan selama 5 siklus dimana 1 siklus terdiri dari PLB 5 kali, dilanjutkan DBE 5 kali dan istirahat selama 2 menit. Studi dilakukan di salah satu rumah sakit di Semarang pada bulan Mei hingga Juni 2023 dengan 5 pasien CHF yang mengalami sesak napas. Setelah dilakukan intervensi menunjukkan terjadinya penurunan frekuensi napas dan skala sesak napas, serta peningkatan saturasi oksigen. Hal ini menunjukkan PLB dan DBE dapat dijadikan sebagai intervensi non farmakologi dalam mengatasi sesak napas pasien CHF. Penelitian selanjutnya diperlukan dengan jumlah responden yang lebih besar untuk meningkatkan keakuratan intervensi.
Least energy solutions for affine p-Laplace equations involving subcritical and critical nonlinearities
Authors: Leite Edir Júnior Ferreira , Montenegro Marcos 
Published: January 2024

Abstract
The paper is concerned with Lane–Emden and Brezis–Nirenberg problems involving the affine p-Laplace nonlocal operator

Δ
p
𝒜

{\Delta_{p}^{\cal A}}

, which has been introduced in [J. Haddad, C. H. Jiménez and M. Montenegro,
From affine Poincaré inequalities to affine spectral inequalities,
Adv. Math. 386 2021, Article ID 107808] driven by the affine

L
p

{L^{p}}

energy

ℰ

p
,
Ω

{{\cal E}_{p,\Omega}}

from convex geometry due to [E. Lutwak, D. Yang and G. Zhang,
Sharp affine

L
p

L_{p}

Sobolev inequalities,
J. Differential Geom. 62 2002, 1, 17–38]. We are particularly interested in the existence and nonexistence of positive

C
1

{C^{1}}

solutions of least energy type. Part of the main difficulties are caused by the absence of convexity of

ℰ

p
,
Ω

{{\cal E}_{p,\Omega}}

and by the comparison

ℰ

p
,
Ω

⁢

(
u
)

≤

∥
u
∥

W
0

1
,
p

⁢

(
Ω
)

{{\cal E}_{p,\Omega}(u)\leq\|u\|_{W^{1,p}_{0}(\Omega)}}

generally strict.