bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature Perturbation with Depth and Induced Pressure in Vicinity of Wellbore During Supercritical CO2/CH4/H2 Injection for Gas Storage Design and Evaluations
Authors: Wang Yarlong 
Published: February 2024

Abstract
CO2/H2/CH4 are injected into subsurface for sequestration and storage purposes. The properties of gases are sensitive to the pressure and temperature, particularly when the supercritical condition is surpassed. Both density and viscosity change are critically dominating the pressure profile and stress induced in vicinity of a wellbore, These induced stresses and pressure must be calculated accurately for safety, injectivity and storage efficiency design. To calculate fluid pressure and induced stresses under different THM environments, a fully coupled THM model with mutiphase fluid may be used. Analytical solution is highly desirable as an efficient engineering tool, but difficult to be achieved. Thus numerical methods are normally utilized. To avoid resorting the complex numerical methods in this study, an coupled THM borehole solution is developed by considering thermal gradient, but the temperature change for a given depth is neglected. Pressure and density profiles in vicinity of a wellbore are studied and implications to field wellbore integrity subject to different injecting flux with perturbated temperature.
Localized Wear in Steel, Glass Fiber and Composite Casings Upon Drillstring Contact: A Full-Scale Experimental Comparison
Authors: Yaqoob T. , Oppelt J. , Holzmann J. , Schamp J. 
Published: February 2024

Abstract
Localized dynamic casing wear due to drillstring contact (predominantly at the tooljoint) is a complex phenomenon to simulate due to the number of control variables influencing the non-linear wear behavior. Wear intensity is influenced by individual combinations of service loads (changing force-area distributions), metallurgical properties (material hardness and yield strength) and tribological parameters (surface roughness, friction factor and wear type).
For wear simulations to be accurate, the required friction- and wear factors must be determined experimentally by full-scale wear tests to be used in model equations. This paper presents a comprehensive account of the experimental work carried out to reproduce friction- and wear factors via full-scale wear tests under variable conditions of casing material, side force, drillstring RPM, axial movement and circulation fluid. The design of the wear test frame, the test method and the application of determined friction- and wear factors to detect casing wear trends under downhole conditions is the core focus of this study. Full scale casing wear tests were carried out while incorporating different casing materials under a selected range of operational loads and lubrication conditions. The outcomes of the wear scenarios were then compared for steel, fibered glass and fibered carbon casings. Results of wear tests have been included and compared in the study for three casing materials under water-based mud lubrication environments.
The test results show a trending wear pattern in terms of friction- and wear factors for all casing materials. After the initial peak values, the wear factor is observed to decline drastically to a steady range due to contact pressure reduction. For all tested materials, this steady range of values can provide a good estimate of field wear volume over time under particular service loads and drilling scenarios. In addition, the measured steady values of friction factors help determine close ranges on contact pressure threshold for the casings. It has been observed from the detected trends in the test results that repeated wear tests can make casing wear predictable.
With the inclusion of more steel grades, casing diameters and casing types into the experimental scope, the wear frame can be used to develop a comprehensive record of wear performance of casings under different field scenarios. Attribution of wear factors and contact pressure thresholds to specific downhole conditions via a wear database, and its integration into a software solution can fill gaps to predict and reduce casing wear while retaining operational flexibility on downhole stresses.
Innovative Technology to Release Stuck Pipe Problems in Gas Wells of Tripura, India - Case Histories
Authors: Lal Kishori , Khan MSBA , Kumar Krishna 
Published: February 2024

Abstract
Stuck pipe incidents are the most troublesome and costliest drilling problem worldwide. in terms of time and financial cost. It's also a major contributor to non-productive time (NPT), which continues to comprise 20-25% of annual rig operating time. This may be due to differential sticking forces, inadequate hole cleaning and the consequent formation of cuttings beds in high angle wells, chemically active formations and inadequate mud weight leading to wellbore instability, fractured/faulted formations, and over-pressured formations.
Sticking can occur while drilling, making a connection, logging, testing, or during any kind of operation which may involve leaving the equipment in the hole. When a pipe sticks the driller usually tries to free it by mechanical movement e.g.by pulling, jarring or, if the pipe was moving immediately prior to sticking, trying to move it in the opposite direction. Frequently this fails to release the pipe as there is a limit to the force which can be applied, since too much force could fracture the pipe and make the situation worse. If the pipe remains stuck then the practice is to apply a Stuck pipe release agent/pill.
It is observed that there are many such pipe release agents/pills known in the industry but these are time-consuming and costly. In those cases where environmental concerns do not permit or discourage their use, diesel oil has been used with a fair amount of success but there are cases where asphalt, diesel oil, mineral oil or other oil-based spotting fluids cannot or should not be used. Many other commercially available, environmentally-friendly spotting fluids have been used in an attempt to free stuck pipe, but with limited success.
It is therefore the primary object to present this paper to provide new and environmentally-friendly more reliable materials which can be used to free stuck pipe. The paper further discusses the current testing and evaluation methods used for screening, testing, and evaluating spotting fluids to select the superior and reject the inferior along with their advantages and disadvantages with existing Mud Systems. Finally, a recommendation is made to improve the testing and evaluation method and overcome the limitations of conventional methods and apparatus.
IL-33 Induces Cellular and Exosomal miR-146a Expression as a Feedback Inhibitor of Mast Cell Function
Authors: Taruselli Marcela T , Abdul Qayum Amina , Abebayehu Daniel , Caslin Heather L , Dailey Jordan M , Kotha Aditya , Burchett Jason R , Kee Sydney A , Maldonado Tania D , Ren Boyang , Chao Wei , Zou Lin , Haque Tamara T , Straus David , Ryan John J 
Published: February 2024

Abstract
IL-33 is an inflammatory cytokine that promotes allergic disease by activating group 2 innate lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade suppresses asthma-like inflammation in mouse models. Homeostatic control of IL-33 signaling is poorly understood. Because the IL-33 receptor, ST2, acts via cascades used by the TLR family, similar feedback mechanisms may exist. MicroRNA (miR)-146a is induced by LPS-mediated TLR4 signaling and serves as a feedback inhibitor. Therefore, we explored whether miR-146a has a role in IL-33 signaling. IL-33 induced cellular and exosomal miR-146a expression in mouse bone marrow–derived mast cells (BMMCs). BMMCs transfected with a miR-146a antagonist or derived from miR-146a knockout mice showed enhanced cytokine expression in response to IL-33, suggesting that miR-146a is a negative regulator of IL-33–ST2 signaling. In vivo, miR-146a expression in plasma exosomes was elevated after i.p. injection of IL-33 in wild-type but not mast cell–deficient KitW-sh/W-sh mice. Finally, KitW-sh/W-sh mice acutely reconstituted with miR-146a knockout BMMCs prior to IL-33 challenge had elevated plasma IL-6 levels compared with littermates receiving wild-type BMMCs. These results support the hypothesis that miR-146a is a feedback regulator of IL-33–mediated mast cell functions associated with allergic disease.
The Role of Fc Receptors in the Innate Immune System of Flounders Purported to Be Homologs of FcγRII and FcγRIII
Authors: Hao Yan-Bo , Xing Jing , Sheng Xiu-Zhen , Chi Heng , Tang Xiao-Qian , Zhan Wen-Bin 
Published: February 2024

Abstract
FcγR is a significant opsonin receptor located on the surface of immune cells, playing a crucial role in Ab-dependent cell-mediated immunity. Our previous work revealed opposite expression trends of FcγRII and FcγRIII in flounder mIgM+ B lymphocytes after phagocytosis of antiserum-opsonized Edwardsiella tarda. This observation suggests that FcγRII and FcγRIII might serve distinct functions in Ig-opsonized immune responses. In this study, we prepared rFcγRIII as well as its corresponding Abs to investigate the potential roles of FcγRII and FcγRIII in the Ab-dependent immune response of IgM+ B cells. Our findings indicate that, unlike FcγRII, FcγRIII does not participate in Ab-dependent cellular phagocytosis. Instead, it is involved in cytokine production and bacterial killing in mIgM+ B lymphocytes. Additionally, we identified platelet-derived ADAM17 as a key factor in regulating FcγRIII shedding and cytokine release in mIgM+ B lymphocytes. These results elucidate the functions of FcγRII and FcγRIII in the innate immunology of mIgM+ B lymphocytes and contribute to an improved understanding of the regulatory roles of FcγRs in the phagocytosis of teleost B lymphocytes.
Fosl2 Deficiency Predisposes Mice to Osteopetrosis, Leading to Bone Marrow Failure
Authors: Chen Jinfeng , Wen Yi , Lin Lili , Cui Yuchen , Chen Zhenyu , Gao Jing , Zhuang Yifang , Chen Qi 
Published: February 2024

Abstract
Arthritis causes Fos-like 2 (Fosl2) inactivation, and various immune cells contribute to its pathogenesis. However, little is known about the role of Fosl2 in hematopoiesis and the possible pathological role of Fosl2 inactivation in the hematopoietic system in arthritis. In this study, we show that Fosl2 maintains hematopoietic stem cell (HSC) quiescence and differentiation while controlling the inflammatory response via macrophages. Fosl2-specific deletion in the hematopoietic system caused the expansion of HSCs and myeloid cell growth while affecting erythroid and B cell differentiation. Fosl2 inactivation enhanced macrophage M1 polarization and stimulated proinflammatory cytokines and myeloid growth factors, skewing HSCs toward myeloid cell differentiation, similar to hematopoietic alterations in arthritic mice. Loss of Fosl2 mediated by Vav-iCre also displays an unexpected deletion in embryonic erythro-myeloid progenitor–derived osteoclasts, leading to osteopetrosis and anemia. The reduced bone marrow cellularity in Vav-iCreFosl2f/f mice is a consequence of the reduced bone marrow space in osteopetrotic mice rather than a direct role of Fosl2 in hematopoiesis. Thus, Fosl2 is indispensable for erythro-myeloid progenitor–derived osteoclasts to maintain the medullary cavity to ensure normal hematopoiesis. These findings improve our understanding of the pathogenesis of bone-destructive diseases and provide important implications for developing therapeutic approaches for these diseases.
How Experts Make a Call
Authors: Srivastava Priyanka , Chaudhry Chakshu , Kaur Anupriya , Phadke Shubha R. , Panigrahi Inusha 
Published: February 2024

Background:
Cytogenetic microarray (CMA) has brought a revolution in the field of cytogenetics by improving resolution by 500 times that of traditional karyotyping. Analysis and interpretation of whole genome copy number variations (CNVs) is quite a challenging task for clinicians. Some software packages and databases are available which are based on algorithm. However, there is no clear rule to decide the pathogenicity.

Objective:
To formulate a step-wise approach to evaluate the interpretation of a CNV and to help the clinicians to interpret the CNV reported by a laboratory with help of four representative cases of different phenotypes.

Methods and Material:
CMA was done using AffymetrixCytoscan 750K array in four cases from different families. Analysis was done based on the proposed approach.

Results:
The prediction of the effect of these CNVs depends on multiple factors and can change over time as the databases are expanded. CMA in four cases from different families revealed, a rare co-occurrence of 22q13.3 duplication and 22q13.3 deletion in a proband, a deletion along with mosaicism on 10q21.2 and 10p15.3, respectively, in the second case. Third case resulted in one variant of unknown significance of 1.2 Kb deletion on 10q11.22 and the fourth case showed a benign CNV. All CNVs were analyzed based on the proposed approach and helped in subsequent management and counselling of the families. The results indicate the effectiveness of a principled, feature-based, statistical framework for uncharacterized CNV interpretation, which future studies can expand upon to construct more reliable classifiers.
Endoscopic Endonasal Excision of a Complex Craniopharyngioma Operated Multiple Times by Transcranial Route
Authors: Patel Biren K , Darshan H R , Binu Anand , Easwer H V , Nair Prakash 
Published: February 2024

Background:
Complex craniopharyngiomas pose a significant surgical challenge owing to its proximity to critical structures and its intrinsic nature to resist radical excision.

Objective:
To show that endoscopic endonasal approach (EEA) is potentially a better alternative to transcranial approach in tumors that have been operated multiple times by transcranial route for achieving radical excision with minimal morbidity.

Materials and Methods:
A 32-year-old male previously operated twice through interhemispheric approach for craniopharyngioma presented with blurring of vision accompanied by headache and intermittent diplopia. Imaging revealed a large lobulated suprasellar recurrence with a large calcified part adjacent to left internal carotid artery. The tumor was resected by an extended endonasal approach. The patient experienced improvement in his vision with no significant endocrine complication.

Results and Conclusion:
This case demonstrates the surgical technique and various operative nuances of endoscopic endonasal resection of a complex craniopharyngioma.
Impact of Extent of Investigation on Causes of Ischemic Stroke in The Young
Authors: Conforto Adriana Bastos , Del Guerra Felipe Borelli , Figueiredo Tamires Rocha , de Almeida Marcele Schettini , Leite Claudia da Costa , Yamamoto Fabio Iuji 
Published: February 2024

Background:
Despite enormous advances in the diagnosis and treatment of ischemic stroke over the past decades, the extent of “standard” investigation to define its causes is heterogeneous. Young patients often undergo a myriad of diagnostic tests in developed countries, but the cost-effectiveness of this approach is uncertain.

Objectives:
Our main goal was to compare the frequencies of ischemic stroke of undetermined and determined etiologies in young patients with “complete” or “incomplete” investigation according to either a stepwise or an extensive protocol.

Methods:
Data from 143 young patients with ischemic stroke were reviewed. For each patient, available data were assessed by means of a stepwise and an extensive protocol of investigation. We compared the frequencies of ischemic stroke of undetermined and determined etiology according to “complete” or “incomplete” investigation according to each protocol.

Results:
Completeness of investigation led to a significant increase in determination of stroke etiology when a stepwise approach but not an extensive protocol was applied.

Conclusions:
These results suggest that ordering an extensive workup to all young patients does not enhance the capability of determining causes of ischemic stroke. Evidence-based guidelines to define pathways of investigation and consensus about the interpretation of tests are deeply needed.
Emerging Trends in Stroke Epidemiology in Indian Women Over the Last Decade
Authors: Dhamija Rajinder K , Aggarwal Abhishek , Saluja Alvee , Parihar Jasmine , Garg Divyani 
Published: February 2024

Background and Objective:
Temporal trends in clinico-epidemiological parameters of stroke among Indian women have not been studied. We aimed to study the changes in these parameters over the last decade.

Material and Methods:
417 strokes (ischemic/hemorrhagic) were prospectively recruited in two timelines. In total, 267 strokes were recruited in 2005 while 150 strokes were recruited in 2016–17. Patients underwent stepwise evaluation via a structured proforma. Demographic factors, stroke subtypes, and risk factors were analyzed.

Results:
Female strokes had a higher mean age in 2017 compared to 2005 (60.90 ± 16.9 vs. 53.21 ± 16.75 years, P = 0.002). Hemorrhagic strokes among females increased over the last decade. Female strokes with dyslipidemia were significantly lower in 2017 compared to 2005 (P = 0.002). Proportion of hypertensive and diabetic strokes were not significantly different between these two periods.

Conclusions:
Over the past decade, the mean age of stroke onset has increased while the prevalence of dyslipidemia has reduced significantly among Indian female stroke patients.
Reversible Hemichorea with Severe Carotid Stenosis
Authors: Raghavendra Seetharam , Ramachandran Jaychandran , Nooraine Javeria , Iyer Rajesh B. 
Published: February 2024

Background:
We report a 74-year-old lady with hemichorea of 6 months duration due to severe carotid stenosis without cerebral infarction. Electroencephalography and single-photon emission computed tomography studies suggested hemispheric abnormality. Hemichorea resolved following carotid endarterectomy.

Discussion:
Hemichorea is the commonest movement disorder following acute stroke. It is rarely reported in association with severe carotid stenosis without evident infarction. In the absence of corresponding structural abnormalities on magnetic resonance imaging in hemichorea, vascular imaging is critical in establishing the diagnosis. Hemichorea in setting of carotid or vascular stenosis is often resistant to medical treatment and best responds to reperfusion.

Conclusion:
Hemichorea due to critical hemispheric ischemia is a well-described rare entity that best responds to reperfusion strategies. Awareness is essential to identify this entity and manage appropriately.
Effect of Karate on Neurocognitive Physiology
Authors: Bhattacharya Puneet , Chatterjee Sridip , Mondal Samiran 
Published: February 2024

Background:
The literature survey shows improvement in cognitive performance following acute bouts of physical exercise and chronic exercise patterns. However, neurocognitive growth through karate, a moderate intensity physical activity, is very limited. The synchronization of the nervous and endocrine system can be best reflected through this martial art form through neurogenesis and cognitive potentiation. Numerous outstanding reviews have summarized these findings for martial arts like judo and taekwondo. This review tries to orchestrate the efficiency of karate in neurocognition.

Objective of the Study:
The specific aim of this review paper is to magnify the efficiency of karate training in cognitive functions, through its response to neurochemical transmissions and electrophysiological signaling

Materials and Method:
Numerous related literature were evaluated, screened, and selected using the Preferred Reporting Items for Systematic reviews and Meta-Analyses eligibility criteria. All appropriate publications that satisfied the primary objective of the study were scientifically and schematically presented in this review paper.

Results:
The psychophysiological effect of karate training and their relation with brain functions have been elaborated. This review compiles the few studies established on the cognitive benefits of karate through the electrical stimuli and neurochemical release.

Conclusion:
Karate may be effective in advancement of particular brain functions and neurocognitive actions through a life time. Electrophysiological studies have unraveled improved neural efficiency, stress tolerance, working and muscle memory but need further exploration. Similarly, to better understand the effects of karate on neurochemical secretions, further research involvement is required.
Does the Serum Expression Level of High-Mobility Group Box 1 (HMGB1) in Multiple Sclerosis Patients have a Relationship with Physical and Psychological Status? A 12-Month Follow-Up Study on Newly Diagnosed MS Patients
Authors: Sharafkhah Mojtaba , Mosayebi Ghasem , Massoudifar Ali , Seddigh Seyed Hamzeh , Abdolrazaghnejad Ali , Alamdara Mobina Aghakarim , Mokarian Peyman , Mohammadbeigi Abolfazl , Ebrahimi-Monfared Mohsen 
Published: February 2024

Background:
There is a strong need to identify simple and cost-effective biomarkers for multiple sclerosis (MS).

Objectives:
To evaluate the serum levels of receptor for advanced glycation end products (RAGE) ligand, the high-mobility group box (HMGB) 1 and its correlation with changes in the physical and psychological indicators in MS patients.

Methods:
During the 12-month follow-up, the serum level of HMGB1, expanded disability status scale (EDSS) score, rate of clinical relapse, quality of life, and other psychological indicators were assessed at baseline, after 6 months, and after 12 months and compared between 60 newly diagnosed MS patients with 60 healthy controls (HCs). Data were analyzed using t-test and Mann–Whitney U test, two-way repeated measures analysis of variance (ANOVA) and Spearman's rank correlation coefficient.

Results:
A significant decrease was observed in the EDSS score (P < 0.001) and a significant increase in the serum level of HMGB1 in all MS patients (P = 0.009). The serum level of HMGB1 was higher in MS patients, compared with HCs (baseline: 65.8%, P = 0.007; six-month follow-up: 73.9%, P = 0.004; and 12-month follow-up: 77.6%, P = 0.021). There were significant positive correlations between the serum level of HMGB1 and scores of MS impact scale-psychological subscale (MSIS-PS) (r = 0.59, P < 0.001), Beck depression inventory (BDI) (r = 0.491, P = 0.031), and Pittsburgh sleep quality index (PSQI) (r = 0.471, P = 0.035).

Conclusion:
The serum level of HMGB1 could predict the patients' psychiatric status better than their physical status.