bluuebunny/crossref_metadata_2025_split huggingface dataset:
The functions of remembering the past and imagining the future during the COVID‐19 pandemic
Authors: Adıgüzel Zeynep , Ay Demet , Bilgin Ezgi , Coşkuner Selin Buse , Ergen İrem , Gülgöz Sami 
Published: February 2024

AbstractIn this study, we explored how the COVID‐19 pandemic affected the functions of autobiographical memory and future projection over time. Between May and June 2020, we asked people (N = 286) to recall or imagine personal events from four time periods: past before the pandemic, past during the pandemic, future during the pandemic, and future after the pandemic ends. Participants rated self, social, directive, predictive, and emotion regulation functions, and the phenomenological characteristics of these events. We found that ratings for all functions decreased for the pandemic and increased for the future. Overall, this study revealed that the COVID‐19 pandemic created a breaking point, with memories being less functional at the beginning of the pandemic compared to the pre‐pandemic times and the future. However, imagined events that would occur after the pandemic ended were rated most functional, suggesting that people were still optimistic about a pandemic‐free future.
Multiscale Structural Triboelectric Aerogels Enabled by Self‐Assembly Driven Supramolecular Winding
Authors: Zhao Jiamin , Zhang Wanglin , Liu Tao , Luo Bin , Qin Ying , Gao Cong , Yuan Jinxia , Wang Shuangfei , Nie Shuangxi 
Published: February 2024

AbstractThe rapid development of wearable electronics has placed higher demands on the design strategies of triboelectric materials. Aerogels have the potential to become advanced triboelectric materials, however, traditional design strategies often require complex processes and additional chemical cross‐linking agents to improve the stability of the gel structure, which limits its practical application. In this work, a scalable and sustainable self‐assembly drive strategy is proposed for the design of bio‐based triboelectric aerogels with multi‐scale winding structures. Interestingly, the autoacceleration effect, which is regarded as “unfavorable” during the autocatalytic polymerization of supramolecules, is rationally exploited to provide the supramolecules within the matrix with an abundance of multiple hydrogen bonds at the same time as their rapid gelation occurs. Thanks to this, the aerogel film exhibits ultra‐high tensile strength (104 MPa) and remains undeformed after resisting an impact of 8000 times its own weight. Highly robust triboelectric aerogel films are used to build wearable self‐powered sensors with ultra‐fast response in complex environments (48 ms), while enabling real‐time interaction between the wearer and the information network. The design idea of “ turning a detriment into an asset ” in this work provides a new idea for the material construction of highly robust wearable sensors.
Hierarchical Composite Scaffold with Deferoxamine Delivery System to Promote Bone Regeneration via Optimizing Angiogenesis
Authors: Wang Raokaijuan , Zha Xiangjun , Chen Jouchen , Fu Ruijie , Fu Yajun , Xiang Jie , Yang Wei , Zhao Lixing 
Published: February 2024

AbstractA bone defect refers to the loss of bone tissue caused by trauma or lesion. Bone defects result in high morbidity and deformity rates worldwide. Autologous bone grafting has been widely applied in clinics as the gold standard of treatment; however, it has limitations. Hence, bone tissue engineering has been proposed and developed as a novel therapeutic strategy for treating bone defects. Rapid and effective vascularization is essential for bone regeneration. In this study, a hierarchical composite scaffold with deferoxamine (DFO) delivery system, DFO@GMs‐pDA/PCL‐HNTs (DGPN), is developed, focusing on vascularized bone regeneration. The hierarchical structure of DGPN imitates the microstructure of natural bone and interacts with the local extracellular matrix, facilitating cell adhesion and proliferation. The addition of 1 wt% of halloysite nanotubes (HNTs) improves the material properties. Hydrophilic and functional groups conferred by polydopamine (pDA) modifications strengthen the scaffold bioactivity. Gelatin microspheres (GMs) protect the pharmacological activity of DFO, achieving local application and sustained release for 7 days. DFO effectively promotes angiogenesis by activating the signaling pathway of hypoxia inducible factor‐1 α. In addition, DFO synergizes with HNTs to promote osteogenic differentiation and matrix mineralization. These results indicate that DGPN promotes bone regeneration and accelerates cranial defect healing.
Recent Advances in Reversible Liquid Organic Hydrogen Carrier Systems: From Hydrogen Carriers to Catalysts
Authors: Zhou Min‐Jie , Miao Yulong , Gu Yanwei , Xie Yinjun 
Published: February 2024

AbstractLiquid organic hydrogen carriers (LOHCs) have gained significant attention for large‐scale hydrogen storage due to their remarkable gravimetric hydrogen storage capacity (HSC) and compatibility with existing oil and gas transportation networks for long‐distance transport. However, the practical application of reversible LOHC systems has been constrained by the intrinsic thermodynamic properties of hydrogen carriers and the performances of associated catalysts in the (de)hydrogenation cycles. To overcome these challenges, thermodynamically favored carriers, high‐performance catalysts, and catalytic procedures need to be developed. Here, significant advances in recent years have been summarized, primarily centered on regular LOHC systems catalyzed by homogeneous and heterogeneous catalysts, including dehydrogenative aromatization of cycloalkanes to arenes and N‐heterocyclics to N‐heteroarenes, as well as reverse hydrogenation processes. Furthermore, with the development of metal complexes for dehydrogenative coupling, a new family of reversible LOHC systems based on alcohols is described that can release H2 under relatively mild conditions. Finally, views on the next steps and challenges in the field of LOHC technology are provided, emphasizing new resources for low‐cost hydrogen carriers, high‐performance catalysts, catalytic technologies, and application scenarios.
Liquid Metal Loaded Molecular Sieve: Specialized Lithium Dendrite Blocking Filler for Polymeric Solid‐State Electrolyte
Authors: Qian Shangshu , Zhu Haojie , Sun Chuang , Li Meng , Zheng Mengting , Wu Zhenzhen , Liang Yuhao , Yang Cheng , Zhang Shanqing , Lu Jun 
Published: February 2024

AbstractAll‐solid–state lithium metal batteries (LMBs) are currently one of the best candidates for realizing the yearning high‐energy–density batteries with high safety. However, even polyethylene oxide (PEO), the most popular polymeric solid‐state electrolyte (SSE) with the largest ionic conductivity in the category so far, has significant challenges due to the safety issues of lithium dendrites, and the insufficient ionic conductivity. Herein, molecular sieve (MS) is integrated into the PEO as an inert filler with the liquid metal (LM) as a functional module, forming an “LM‐MS‐PEO” composite as both SSE with enhanced ionic conductivity, and protection layer against lithium dendrites. As demonstrated by theoretical and experimental investigations, LM released from MS can be uniformly and efficiently distributed in PEO, which could avoid agglomeration, enable the effective blocking of lithium dendrites, and regulate the mass transport of Li ions, thus achieving even deposition of lithium during charge/discharge. Moreover, MS could reduce the crystallinity of PEO, improve lithium‐ion conductivity, and reduce operating temperature. Benefiting from the introduction of the functional MS/LM, the LM‐MS‐PEO electrolyte exhibits fourfold higher lithium ionic conductivity than the pristine PEO at 40 °C, while the as‐assembled all‐solid–state LMBs have four to five times longer stable cycle life.
Juice Vesicles Bioreactors Technology for Constructing Advanced Carbon‐Based Energy Storage
Authors: Shen Shenghui , Chen Yanbin , Gu Xinyi , Chen Ketong , Qiu Zhong , Liu Ping , Zhang Yongqi , Xiang Jiayuan , Yang Yefeng , Cao Feng , Wang Chen , Wan Wangjun , He Xinping , Liang Xinqi , Bao Ningzhong , Chen Minghua , Xia Yang , Xia Xinhui , Zhang Wenkui 
Published: February 2024

AbstractThe construction of high‐quality carbon‐based energy materials through biotechnology has always been an eager goal of the scientific community. Herein, juice vesicles bioreactors (JVBs) bio‐technology based on hesperidium (e.g., pomelo, waxberry, oranges) is first reported for preparation of carbon‐based composites with controllable components, adjustable morphologies, and sizes. JVBs serve as miniature reaction vessels that enable sophisticated confined chemical reactions to take place, ultimately resulting in the formations of complex carbon composites. The newly developed approach is highly versatile and can be compatible with a wide range of materials including metals, alloys, and metal compounds. The growth and self‐assembly mechanisms of carbon composites via JVBs are explained. For illustration, NiCo alloy nanoparticles are successfully in situ implanted into pomelo vesicles crosslinked carbon (PCC) by JVBs, and their applications as sulfur/carbon cathodes for lithium–sulfur batteries are explored. The well‐designed PCC/NiCo‐S electrode exhibits superior high‐rate properties and enhanced long‐term stability. Synergistic reinforcement mechanisms on transportation of ions/electrons of interface reactions and catalytic conversion of lithium polysulfides arising from metal alloy and carbon architecture are proposed with the aid of DFT calculations. The research provides a novel biosynthetic route to rational design and fabrication of carbon composites for advanced energy storage.
Comparing fluorodeoxyglucose positron emission tomography with computed tomography in staging for nodal and distant metastasis in urothelial/bladder cancer
Authors: Al‐Zubaidi Mohammed , Ong Katherine , Viswambaram Pravin , Bangash Haider , Boardman Glenn , McCombie Steve P. , Oey Oliver , Swarbrick Nicole , Redfern Andrew , Ong Jeremy , Gauci Richard , Low Ronny , Hayne Dickon 
Published: February 2024

AbstractObjectivesWe aim to assess the clinical value of 18F‐fluorodeoxyglucose positron (18F‐FDG‐PET) scan in detecting nodal and distant metastasis compared with computed tomography (CT) scan in patients with urothelial carcinoma or bladder cancer, aiming to improve staging accuracy and thereby better prognosticate and determine therapy.MethodsA retrospective review of 75 patients with invasive bladder cancer (≥T1) who were staged with both CT and 18F‐FDG‐PET within an 8‐week interval was performed for the period between 2015 and 2020. Seventy‐two per cent (54/75) had formal pelvic lymph node (LN) dissection or biopsy of lesions suspicious for metastases. FDG‐PET definitions for positive sites were assessed depending on SUV Max (nodes with SUVmax >4 at any size, SUV > 2 for lymph nodes >8 mm, or any SUV if the lymph node was >10 mm on axial images). For CT scanning, enlarged LN by RECIST 1.1 criteria (>10 mm) as well as qualitative findings suggesting metastasis were considered positive. The analysis was based on the comparison of CT and 18F‐FDG‐PET findings to histopathology results from LN dissection or biopsies.ResultsSensitivity, specificity, positive predictive values (PPV) and negative predictive value (NPV) of CT versus FDG‐PET for detecting metastasis, in patients who underwent pelvic LN dissection or biopsy of lesions suspicious of metastases, were 46.6% (95% CI: 21%–70%) versus 60% (95% CI: 32%–84%), 100% (95% CI: 91%–100%) versus 83.78% (95% CI: 69%–94%), 100% (95% CI: 63%–100%) versus 60% (95% CI: 32%–84%), and 82.2% (95% CI: 68%–92%) versus 83.78% (95% CI: 69%–94%), respectively. 7/75 (9.3%) patients avoided cystectomy due to 18F‐FDG‐PET features of metastases that were not detected by CT.ConclusionFDG‐PET may be more sensitive than CT for metastases in the staging of bladder cancer, which resulted in significant avoidance of aggressive local management in cases with occult metastasis.
Role for CCN1 in lysophosphatidic acid response in PC‐3 human prostate cancer cells
Authors: Balijepalli Pravita , Knode Brianna K. , Nahulu Samuel A. , Abrahamson Emily L. , Nivison Mary P. , Meier Kathryn E. 
Published: February 2024

AbstractLysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) are bioactive phospholipids that act as mitogens in various cancers. Both LPA and S1P activate G‐protein coupled receptors (GPCRs). We examined the role of CCN1/CYR61, an inducible matricellular protein, in LPA‐induced signal transduction in PC‐3 human prostate cancer cells. We found that both LPA and S1P induced expression of CCN1 and CCN2 within 2–4 h. CCN1 was induced by 18:1‐LPA, but not by 18:0‐, 18:2‐, or 18:3‐LPAs. A free fatty acid receptor‐4 agonist inhibited LPA‐induced CCN1 induction. CCN1 appeared in the ECM within 2 h after LPA addition. LPA caused biphasic activation of Erk MAPK, with an initial peak at 10–20 min followed by a later phase after 6 h. LPA increased adhesion of PC‐3 cells to culture substrates (standard culture plates, fibronectin, or extracellular matrix) at 2 h, an intermediate event between early and late LPA signals. Knockdown of CCN1 suppressed LPA‐induced adhesion to ECM or fibronectin. ECM from CCN1 knockdown cells was a poor substrate for adhesion, as compared to ECM from control cells. These results suggest that CCN1 contributes to LPA responses in the tumor microenvironment. The LPA‐CCN1 axis holds promise for the development of novel therapeutic strategies in cancer.
Nutrients from spawning salmon influence leaf area, tissue density, and nitrogen‐15 in riparian plant leaves
Authors: Dennert Allison M. , Elle Elizabeth , Reynolds John D. 
Published: February 2024

AbstractNutrient subsidies have significant impacts on ecosystems by connecting disjunct habitats, often through long‐distance animal migrations. Salmon migrations on the North Pacific coasts provide these kinds of nutrient subsidies from senescent fish at the end of their life cycle, which can have significant ecological effects on terrestrial species. This can include impacts on individuals, populations, and communities, where shifts in community composition towards plant species that indicate nitrogen‐rich soils have been documented. We investigated the effects of variation in salmon spawning density on the leaf traits of four common riparian plant species on the central coast of British Columbia, Canada. We found that all plant species had higher foliar salmon‐derived nitrogen on streams with a higher spawning density. Three of the four species had larger leaves, and one species also had higher leaf mass per area on streams with more salmon. However, we found no differences in leaf greenness or foliar percent nitrogen among our study streams. These results demonstrate that nutrient subsidies from spawning salmon can have significant impacts on the ecology, morphology, and physiology of riparian plants, which lends support to a mechanism by which certain plants are more common on productive salmon streams.
Jellyfish stings‐induced cardiac failure was ameliorated through AAG‐mediated glycogen‐driven ATP production
Authors: Qin Zhen , Chen Jinhong , Liu Fang , Li Bingbing , Zhang Chenchen , Wang Xiuxiu , Liu Lin , Wang Mingke , Wang Tingfang , Wang Su , Yu Feifei , Wang Shifeng , Yang Jishun 
Published: February 2024

AbstractJellyfish stings have become a common injury among fishermen and divers. Severe jellyfish stings could worsen cardiac function and even cause cardiac complications, ultimately leading to cardiac failure (CF). Currently, there are no effective drugs available. Single cell sequencing revealed alpha‐1 acid glycoprotein (AAG), an energy regulatory protein targeting to glycogen, was highly expressed in jellyfish stings‐induced CF patients. However, the mechanism remains elusive. It is postulated that AAG could increase glycogen metabolism, protecting against jellyfish stings‐induced CF. AAG deletion exacerbated CF, while exogenous and endogenous AAG ameliorated CF. AAG also rescued the decline triggered by the AAG knockout (KO). Intriguingly, AAG improved cardiac function and metabolic adaptation by glycogen‐driven ATP production, shifting mitochondrial/glycolytic ATP production towards glycolysis. Sorted by single‐cell RNA sequencing and spatial transcription technology, CC‐chemokine receptor 5 (CCR5) and Peroxisome proliferator‐activated receptor‐gamma coactivator‐1alpha (PGC‐1α) were differentially expressed. Mechanistically, CCR5 inhibitor MVC abolished AAG's protective effect and PGC‐1α overexpression. Collectively, jellyfish stings‐induced CF was ameliorated through AAG‐mediated glycogen‐driven ATP production, promoting glycolytic/mitochondrial metabolic switches to rely energetically primarily on glycolysis, which might serve as a therapeutic target of CF.
Deep learning‐based BMI inference from structural brain MRI reflects brain alterations following lifestyle intervention
Authors: Finkelstein Ofek , Levakov Gidon , Kaplan Alon , Zelicha Hila , Meir Anat Yaskolka , Rinott Ehud , Tsaban Gal , Witte Anja Veronica , Blüher Matthias , Stumvoll Michael , Shelef Ilan , Shai Iris , Riklin Raviv Tammy , Avidan Galia 
Published: February 2024

AbstractObesity is associated with negative effects on the brain. We exploit Artificial Intelligence (AI) tools to explore whether differences in clinical measurements following lifestyle interventions in overweight population could be reflected in brain morphology. In the DIRECT‐PLUS clinical trial, participants with criterion for metabolic syndrome underwent an 18‐month lifestyle intervention. Structural brain MRIs were acquired before and after the intervention. We utilized an ensemble learning framework to predict Body‐Mass Index (BMI) scores, which correspond to adiposity‐related clinical measurements from brain MRIs. We revealed that patient‐specific reduction in BMI predictions was associated with actual weight loss and was significantly higher in active diet groups compared to a control group. Moreover, explainable AI (XAI) maps highlighted brain regions contributing to BMI predictions that were distinct from regions associated with age prediction. Our DIRECT‐PLUS analysis results imply that predicted BMI and its reduction are unique neural biomarkers for obesity‐related brain modifications and weight loss.
Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia cohort consortium
Authors: Yin Xin , Kishida Rie , Abe Sarah Krull , Islam Md. Rashedul , Rahman Md. Shafiur , Saito Eiko , Lan Qing , Blechter Batel , Merritt Melissa , Choi Ji‐Yeob , Shin Aesun , Katagiri Ryoko , Shu Xiao‐Ou , Sawada Norie , Tamakoshi Akiko , Koh Woon‐Puay , Tsuji Ichiro , Nagata Chisato , Park Sue K. , Kweon Sun‐Seog , Gao Yu‐Tang , Tsugane Shoichiro , Kimura Takashi , Yuan Jian‐Min , Lu Yukai , Kanemura Seiki , Sugawara Yumi , Wada Keiko , Shin Min‐Ho , Ahsan Habibul , Boffetta Paolo , Chia Kee Seng , Matsuo Keitaro , Qiao You‐Lin , Rothman Nathaniel , Zheng Wei , Inoue Manami , Kang Daehee , Seow Wei Jie 
Published: February 2024

AbstractPrevious studies have investigated the association between reproductive factors and lung cancer risk; however, findings have been inconsistent. In order to assess this association among Asian women, a total of 308,949 female participants from 11 prospective cohorts and four Asian countries (Japan, Korea, China, and Singapore) were included. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CIs). A total of 3,119 primary lung cancer cases and 2247 lung cancer deaths were identified with a mean follow‐up of 16.4 years. Parous women had a lower risk of lung cancer incidence and mortality as compared with nulliparous women, with HRs of 0.82 (95% CI = 0.70–0.96) and 0.78 (95% CI = 0.65–0.94). The protective association of parity and lung cancer incidence was greater among ever‐smokers (HR = 0.66, 95% CI = 0.49–0.87) than in never‐smokers (HR = 0.90, 95% CI = 0.74–1.09) (P‐interaction = 0.029). Compared with age at first delivery ≤20 years, older age at first delivery (21–25, ≥26 years) was associated with a lower risk of lung cancer incidence and mortality. Women who ever used hormone replacements had a higher likelihood of developing non‐small cell lung cancer (HR = 1.31, 95% CI = 1.02–1.68), compared to those who never used hormone replacements. Future studies are needed to assess the underlying mechanisms, the relationships within these female reproductive factors, and the potential changes in smoking habits over time.
Pseudomonas aeruginosa infections and improper storage conditions influence the performance of 1,3‐β‐d‐glucan in diagnosis of invasive fungal infections
Authors: Wei Zilan , Xu Jie , Yuan Fang , Fang Wendong , Wu Jiahui , Wang Youliang , Chen Shuiping 
Published: February 2024

AbstractBackgroundThe association between 1,3‐β‐d‐glucan (BDG) levels and infections caused by Pseudomonas aeruginosa or Streptococcus pneumoniae, and the stability of BDG under different storage conditions are unclear.MethodsStrains of Pseudomonas aeruginosa and S. pneumoniae were grown in medium and human serum. The BDG concentrations in culture supernatants were measured. The specificity and stability of BDG were also evaluated.ResultsP. aeruginosa produced high levels of BDG in Luria–Bertani medium (>4 × 104 pg/mL) and human serum (527.0 pg/mL), whereas S. pneumoniae produced low levels of BDG in THY medium (175.6 pg/mL) and human serum (78.3 pg/mL). The BDG produced by these two bacteria was specifically degraded by 1,3‐β‐d‐glucanase. BDG was degraded when stored at different temperatures, decreasing by 22.5% and 9.3% at −20°C and −70°C, respectively, for 63 days; by 30.7% at 4°C for 12 days; and by 12.6% and 22.0% at 37°C for 6 and 12 h.ConclusionBDG false‐positivity must be considered in patients with bacteremia caused by P. aeruginosa when diagnosing invasive fungal infection. Human serum samples for the BDG test in medical facilities should be tested as soon as possible or stored at low temperatures before testing.
Intestinal Neuronal Dysplasia in Twins
Authors: Kobayashi Hiroyuki , Mahomed Anies , Puri Prem 
Published: February 2024

SummaryIntestinal neuronal dysplasia (IND) has been described proximal to the aganglionic segment in Hirschsprung's disease and less frequently as an isolated condition. Familial occurrence of IND is rare. We report a case of monozygotic twins affects with IND. One‐year‐old male monozygotic twins presented with a history of chronic constipation and abdominal distension since birth. At presentation, both twins had fecal impaction with palpable fecal‐filled loops of bowel. Barium enema in both patients showed gross fecal loading of the sigmoid colon and rectum. Delayed films taken at 48 h showed marked barium retention. Suction rectal biopsy specimens examined by acetylcholinesterase (AChE) histochemistry in both patients showed moderately increased AChE‐positive nerve fibers in the lamina propria, muscularis mucosae, and around submucosal blood vessels, as well as hyperplasia of submucous plexus with formation of giant ganglia. Both children underwent extended internal sphincter myectomy. Six months later, both patients had normal bowel function. The occurrence of IND in twins suggests that genetic factors are involved in the etiology of this disease.