bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial
Authors: Bell Imogen , Arnold Chelsea , Gilbertson Tamsyn , D’Alfonso Simon , Castagnini Emily , Chen Nicola , Nicholas Jennifer , O’Sullivan Shaunagh , Valentine Lee , Alvarez-Jimenez Mario 
Published: October 2023

Background
Repetitive negative thinking (RNT) is a key transdiagnostic mechanism underpinning depression and anxiety. Using “just-in-time adaptive interventions” via smartphones may disrupt RNT in real time, providing targeted and personalized intervention.

Objective
This pilot randomized controlled trial evaluates the feasibility, acceptability, and preliminary clinical outcomes and mechanisms of Mello—a fully automated, personalized, transdiagnostic, and mechanistic smartphone intervention targeting RNT in young people with depression and anxiety.

Methods
Participants with heightened depression, anxiety, and RNT were recruited via social media and randomized to receive Mello or a nonactive control over a 6-week intervention period. Assessments were completed via Zoom sessions at baseline and at 3 and 6 weeks after baseline.

Results
The findings supported feasibility and acceptability, with high rates of recruitment (N=55), uptake (55/64, 86% of eligible participants), and retention (52/55, 95% at 6 weeks). Engagement was high, with 90% (26/29) and 59% (17/29) of the participants in the Mello condition still using the app during the third and sixth weeks, respectively. Greater reductions in depression (Cohen d=0.50), anxiety (Cohen d=0.61), and RNT (Cohen d=0.87) were observed for Mello users versus controls. Mediation analyses suggested that changes in depression and anxiety were accounted for by changes in RNT.

Conclusions
The results indicate that mechanistic, targeted, and real-time technology-based solutions may provide scalable and effective interventions that advance the treatment of youth mental ill health.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12621001701819; http://tinyurl.com/4d3jfj9f
Evaluation of the risk of occupational exposure to antineoplastic drugs in healthcare sector: part I – medical gloves
Authors: Dugheri Stefano , Squillaci Donato , Cappelli Giovanni , Saccomando Valentina , Fanfani Niccolò , Ceccarelli Jacopo , Mucci Nicola , Arcangeli Giulio 
Published: October 2023

Abstract
Antineoplastic drugs (ADs) are essential tools in cancer treatment, but their cytotoxicity poses a risk to workers involved in their handling. In a hospital environment fundamental strategies for minimising exposure involve proper use of safety cabinets and closed-circuit transfer devices, along with personnel training and increased awareness of risks. However, medical gloves remain the first line of defence. In this respect the evaluation of glove materials and best choices can improve hospital safety management and prevent potential hazards and long-term consequences. The aim of this study was to assess contamination of gloves in samples taken from AD administration and preparation units of nine Italian hospitals and to raise awareness of the importance of evaluating chemico-physical properties of gloves. Our findings show that 33 % of the analysed gloves were positive for at least one AD, with contaminations ranging from 0.6 to 20,729 pg/ cm2. We proposed the alert glove values (AGVs) for each AD as a limit value for contamination assessment and good practice evaluation. Our findings also point to multiple AD contamination (43 % of positive findings in preparation units), calculated as total AGV (AGV-T), and confirm that gloves should be replaced after 30 min of AD handling, based on cumulative permeation and area under the curve (AUC), to maintain safety and limit dermal exposure.
Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice
Authors: Jutrić David , Đikić Domagoj , Boroš Almoš , Odeh Dyana , Gračan Romana , Beletić Anđelo , Jurčević Irena Landeka 
Published: October 2023

Abstract
Valproate is known to disturb the kidney function, and high doses or prolonged intake may cause serum ion imbalance, kidney tubular acidosis, proteinuria, hyperuricosuria, polyuria, polydipsia, and dehydration. The aim of this in vivo study was to see whether naringin would counter the adverse effects of high-dose valproate in C57Bl/6 mice and to which extent. As expected, valproate (150 mg/kg bw a day for 10 days) caused serum hyperkalaemia, more in male than female mice. Naringin reversed (25 mg/kg bw a day for 10 days) the hyperkalaemia and activated antioxidative defence mechanisms (mainly catalase and glutathione), again more efficiently in females. In males naringin combined with valproate was not as effective and even showed some prooxidative effects.
Effects of concomitant use of THC and irinotecan on tumour growth and biochemical markers in a syngeneic mouse model of colon cancer
Authors: Žunec Suzana , Karačonji Irena Brčić , Čatalinac Martin , Jurič Andreja , Katić Anja , Kozina Goran , Micek Vedran , Neuberg Marijana , Vrdoljak Ana Lucić 
Published: October 2023

Abstract
Clinical treatment with the antineoplastic drug irinotecan (IRI) is often hindered by side effects that significantly reduce the quality of life of treated patients. Due to the growing public support for products with Δ9-tetrahydrocannabinol (THC), even though relevant scientific literature does not provide clear evidence of their high antitumour potential, some cancer patients take unregistered preparations containing up to 80 % THC. This study was conducted on a syngeneic colorectal cancer mouse model to test the efficiency and safety of concomitant treatment with IRI and THC. Male BALB/c mice subcutaneously injected with CT26 cells were receiving 60 mg/kg of IRI intraperitoneally on day 1 and 5 of treatment and/or 7 mg/kg of THC by gavage a day for 7 days. Treatment responses were evaluated based on changes in body, brain, and liver weight, tumour growth, blood cholinesterase activity, and oxidative stress parameters. Irinotecan’s systemic toxicity was evidenced by weight loss and high oxidative stress. The important finding of this study is that combining THC with IRI diminishes IRI efficiency in inhibiting tumour growth. However, further studies, focused on more subtle molecular methods in tumour tissue and analytical analysis of IRI and THC distribution in tumour-bearing mice, are needed to prove our observations.
L-glutamic acid-g-poly hydroxyethyl methacrylate nanoparticles: acute and sub-acute toxicity and biodistribution potential in mice
Authors: Bakan Buket , Oltulu Fatih , Yıldırım Yeliz , Yavaşoğlu Altuğ , Akgöl Sinan , Karabay Yavaşoğlu Nefise Ülkü 
Published: October 2023

Abstract
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.
The Use of Vitamin Supplements and Herbal Medicines Among Members of Elderly Posyandu During the COVID-19 Pandemic in North Jakarta
Authors: Atalo N. S. S. , Suryatinah Y. , Ferdina A. R. , Siahaan S. 
Published: October 2023

Abstract

Background:
During the COVID-19 pandemic, the elderly have been identified as a particularly vulnerable group. The use of vitamin supplements and herbal medicines to enhance immunity has been a measure to prevent the development of COVID-19.

Purpose:
This study was performed to identify the use of supplemental vitamins and herbal medicines including analyzing the benefit of using them among the elderly who participated in the “Mawar” Elderly Posyandu (integrated health post) in North Jakarta, Indonesia, during the pandemic.

Materials and methods:
This was a descriptive study with a cross-sectional design. The target population for the study were active participants of “Mawar” Elderly Posyandu aged at least 60 years old.

Results:
Although the majority of respondents only had an elementary and high school education as their highest educational attainment, they had good enough knowledge about COVID-19. During the pandemic, 81 and 79 out of 85 respondents consumed vitamin supplements and herbal medicines, respectively. Vita-min C and ginger were the most widely used vitamin supplement and herbal product. There were 55.56% and 35.44% of respondents who felt better after consuming supplements and herbal products for one week.

Conclusion:
This study recommends that government should support the revitalization of elderly Posyandu as it may improve the awareness of the community to maintain their health.
Prospects for the development of Ukrainian-Polish cross-border cooperation in the environmental sphere
Authors: Skorokhod Iryna , Rebryna Nina 
Published: October 2023

Abstract

Subject and purpose of work:
The purpose of the article is to study the peculiarities of the development of environmental cross-border cooperation, as well as to determine the prospects and ways of deepening interregional Ukrainian-Polish cooperation in the environmental sphere. The relevant international environmental cooperation of the states contributes to the improvement of the environment and provides a defined level of environmental safety. The challenges of international economic greening as well as the needs in cooperation between the neighboring states indicate that studying of the ecological state on the cross-border territories is considered to be of great significance.

Materials and methods:
The methods used are the analytical and descriptive ones based on the critical literature review and an experiential reflective attitude on the key issues concerning the cross-border cooperation, ecological safety, and prospects of development of environmental cooperation.

Results:
The role of cross-border cooperation in ensuring environmental security was studied in the article. The strategic priorities of Ukrainian-Polish environmental cooperation were considered. As a result of the analysis of the current state and the achieved results, the prospects for further ecological cooperation between Ukraine and the Republic of Poland in the conditions of European integration were revealed.

Conclusions:
It is concluded that to assure the development of the Ukrainian-Polish cross-border environmental cooperation and to build the ecological safety system on the trans-frontier territories it is required at the regional level to establish partnership relationships in the environmental and economic sector; to intensify the environmental and economic international cooperation at various cross-border scales; to create a network of cross-border environmental information centers; to promote the environmental public education in the border regions of the neighboring states etc.
Modified Bivariate Poisson-Lindley Model: Properties and Applications in Soccer
Authors: Haddari Allaeddine , Zeghdoudi Halim , Vinoth Raman 
Published: October 2023

Abstract
This paper presents the bivariate Poisson-new XLindley distribution (BPNXLD), which may be used to represent dependent and over-dispersed countdata. Among the characteristics considered are the correlation coefficient, mean, and variance of the distribution. Acomparison with several Bivariate distributions is included. The goodness of fit of this novel model iscompared with the bivariate Poisson, bivariate negative binomial and bivariate Poisson-Lindley distributions using two data sets from a German Bundesliga season.
The Interaction Principle in the Assessment of Pillars’ Secondary Stress-Deformation State
Authors: Toderaș Mihaela , Iosif Cristian 
Published: October 2023

Abstract
In the field of mining, one of the exploitation methods that is still the most used in rock salt, potassium, and magnesium salt deposits is the method with the room and abandoned pillar. The salt mining method with rooms and pillars represents a unique spatial system for which the establishment of an optimal correlation between the parameters of the room, pillar, and rock massif is required in any given situation. Thus, the dimensioning of the most requested element in the system is followed, and depending on its parameters, the other parameters of the system are established. Considering the exploitation method with rooms and pillars, the pillars are certainly the elements that are subjected to the greatest loads. In the situation where the deep exploitation of salt is done with square pillars, the evaluation of the optimal parameters of the elements of the exploitation system requires: establishing the loads that appear in the surrounding salt massif (the natural stress state); the qualitative-quantitative determination of the way of distribution of the secondary stress state in the pillars; evaluating the bearing capacity of the pillars; and establishing their geometric elements. Solving this problem can be achieved by different methods: based on the theory of limit equilibrium, taking into account the effective stress in the pillars; methods of the mechanics of the continuous system based on the analytical models for evaluating the secondary stress and deformation state of pillars and floors; and numerical methods combined with the results and measurements from the laboratory and in situ tests. A methodology based on the pillar–room–salt massif interaction principle was proposed for the analytically achievable stability exploitation system of rock salt by the dry method as the depth increased. Applying this method, the secondary stress-deformation state in the pillar can be established by taking into account the rheological behaviour of the salt, changing the pillar shape, and the extraction technology. The presented algorithm can be extended in the field of exploitation, where the room and pillar exploitation methods are used.
Rheological Characteristics of the Rock Salt from Slanic Prahova, Horizon XIV Below Level of 200m
Authors: Toderaș Mihaela , Militaru Ștefan 
Published: October 2023

Abstract
The long-term response and stability of underground mining works are crucial for ensuring the safety of workers, preventing costly accidents, and maintaining efficient operations. This is primarily due to the critical role these structures play in various industries, including mining, construction, and transportation. Understanding the long-term response and stability of such structures is an important factor for ensuring their durability and safety. Additionally, advancements in technology and engineering practices have allowed for more accurate assessments and predictions of long-term behaviour, leading to improved design and maintenance strategies. By examining the creep and relaxation behaviour, scientists can gain insights into the mechanical properties and stability of rocks under different conditions. The time-dependent experiments involve subjecting the rocks to varying rates of loading or deformation to understand their behaviour under different conditions. These methods provide valuable insights into the time-dependent properties of rocks, allowing researchers to better understand their response to various geological processes and engineering applications. This study was carried out in order to determine the rheological characteristics of the rock salt from Slanic Prahova mine, horizon XIV, and to analyse the local stability and the general stability of the resistance structures. The results of the experimentally determined rheological characteristics showed that the analysed salt has a pronounced tendency to creep, being able to be classified in creep category 5, which is a pronounced creep. The values obtained for the dilatancy threshold confirm the fact that salt is a material system that exhibits dilatancy.
The Role of Remittances in Financing the Current Account Deficit: The Case of Serbia
Authors: Čakajac Božidar , Janković Nenad , Luković Stevan 
Published: October 2023

Abstract
Migrations of the resident population in Serbia, with the Western European countries as the main destination, have influenced remittances becoming an important source of income from abroad. Relevant economic literature, as well as the influential views expressed in the international financial institutions’ reports, indicate that remittances are a more stable type of inflow of funds from abroad to developing countries compared to other types of capital movements. In addition to the positive economic effects of remittances, they also play a significant role in the balance of payments deficit reduction. The subject of this research refers to the examination of the role of remittances in financing the current account deficit in Serbia. The research goal is to explore whether the importance of remittances as a factor in the balance of payments deficit reduction in Serbia increased in the period 2007-2021. The results of the research show that remittances have become an important factor in current account deficit reduction in Serbia during the observed period.
Composition of Mastitis Causing Microorganisms and Cytokines in Healthy Cow’s Milk: A Pilot Study
Authors: Junga Anna , Pilmane Māra , Šerstņova Ksenija , Lohova Elizabeta , Melderis Ivars , Gontar Łukasz , Kochański Maksymilian , Drutowska Andżelika , Maróti Gergely , Prieto-Simón Beatriz 
Published: October 2023

Abstract
The aim of this study was to examine clinically healthy cow’s udder milk microbiota and presence of cytokines in different seasons. Milk samples taken from the cows were checked for the presence of Gram-positive and Gram-negative bacteria, and the somatic cell count was detected. Immunohistochemistry methods were performed to detect interleukin (IL) -2, IL-4, IL-8, IL-10, IL-12, IL-17a, β-defensin-3, transforming growth factor (TGF)-ā1, interferon-ć and nuclear factor (NF)-źB presence in the milk. S. agalactiae, S. uberis, S. aureus, E. coli, and Klebsiella, Enterobacter, Citrobacter spp. were found in healthy cow’s milk. In the first round, the highest prevalence was observed for S. aureus. In the second round, the highest mean levels were observed for S. uberis, then followed S. aureus. IL-4, IL-17a and TGF-ā1 demonstrated the highest expression in the milk samples. NF-źB had the lowest expression among all factors. The presence of a rich bacterial microbiome (mostly S.aureus, S.uberis) in the milk of healthy animals, as well as changing bacterial species between in spring and autumn seasons occur as a result of both the immune state of the animal and many external factors, which consequently affects the amount of expressed cytokines.
Primary Burkitt Lymphoma of the Rectum
Authors: Kokaine Linda , Briede Inese , Brikuns Andrejs , Gardovskis Andris , Gardovskis Jānis 
Published: October 2023

Abstract
Burkitt lymphoma (BL) is a highly aggressive mature B-cell neoplasm with the highest incidence in a pediatric population. Three clinical subtypes of BL are known: sporadic, endemic, and immune deficiency associated. The most common site of involvement in the case of the sporadic form is an ileocecal region. We describe a rare case of sporadic BL in a 71-year-old male with a primary localisation in the rectum presenting with progressive bowel obstruction and rectal bleeding. The clinical evaluation involved colonoscopy, biopsy with a following morphological examination, computerised tomography of thorax, abdomen and pelvis, magnetic resonance imaging of pelvis, and laboratory analysis. Due to the unclear tumorous mass and progressive clinical symptoms, surgical treatment was applied – laparotomy, total mesorectal excision with the formation of permanent colostomy. Morphological examination of the specimen revealed a phenotype characteristic to BL. One month after the surgery, two single liver metastasis were detected. The patient received six courses of DA-EPOCH chemotherapy. Post-treatment radiological examinations revealed full clinical remission and disease-free survival for 68 months (5 years and 8 months).
Approximate Solution of Optimal Pulse Control Problem Associated with the Heat Conduction Process
Authors: Mammadov Rashad , Gasimov Sardar , Karimova Sevinj , Abbasov Ibrahim 
Published: October 2023

Abstract
We consider the approximate solution of the control problem with minimum energy for an object described by the heat equation, with the process described by the linear equation of parabolic type and the system controlled by impulsive external influences. Our optimal control problem deals with finding a control parameter belonging to the class of admissible controls that provides the desired temperature distribution in a finite time with minimal energy consumption (energy consumption is described by the quadratic functional). Previous works dedicated to optimal impulse control problems have mostly used the Pontryagin’s maximum principle. However, from a practical point of view, this approach does not lead to satisfactory results. This is due to the fact that the corresponding boundary value problems in this case have no solution in a traditional class of absolutely continuous trajectories. In this work, we propose a method based on the moment relations. We seek for the approximate solution of the corresponding boundary value problem in the form of finite Fourier sum and state our optimal control problem in a finite-dimensional phase space. As a result, we obtain an optimal impulse control problem in a finite-dimensional function space. Taking into account the given condition for a finite time, we reduce the obtained problem to the L-problem of moments. Thus, the problem of finding a control parameter is reduced to the solution of the system of Fredholm integral equations of the first kind, with the norm of the sought solution not exceeding a given number. By Levi’s theorem, every element of Hilbert space can be represented by the sum of the elements of two orthogonal subspaces. This assertion makes it possible to find control parameters in analytical form. We also establish the convergence of the chosen approximation.