bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of indicators of the functional state of the body and working capacity in young schoolchildren with different school success
Authors: Levchin A. M. , Lebedenko A. A. , Ershova I. B. , Rogovtsova A. G. 
Published: December 2023

Objective: to study the indicators of the functional state of the body and working capacity in the dynamics of learning in elementary school children with different school success.Materials and methods: the study included 573 elementary school students. Group I – 82 students with excellent academic performance Group II – 491 children with good academic performance. The vegetative index of Kerdo (VIC), the Rufier test, the Genchi test, and the adaptive index (AP) were determined by the method of F. Halberg. The mental performance of younger schoolchildren was studied using Schulte tables.Results: the values of VIC in group I children were 2.5–3.5 times higher. The difference in IR between the groups increased, amounting to 32.88% in the 4th grade. The Gencha sample was characterized by lower values (by 1–2 seconds) in group I children. The difference in AP in the 1st grade was 4.73 sec., then in the 4th grade –6.86 sec. The Schulte tables showed higher values of work efficiency, workability and endurance coefficient along with a decrease in speed and strength indicators and physical endurance.Conclusions: by the end of primary school, the vegetative balance in group I children is between normo- and sympathicotonia. The Gencha test made it possible to establish insufficient resistance of the body to hypoxia. Children of group II demonstrated better adaptive capabilities of the CCC, speed and strength indicators and physical endurance. The data obtained must be taken into account in the pedagogical process with younger schoolchildren and require the development of differentiated recreational activities.
Features of both immune and psycho-emotional factors in the adaptive reactions of first-year students
Authors: Urazmambetov R. T. , Chebotov S. A. , Loboda T. V. 
Published: December 2023

Objective: comparative characteristics of indicators of psycho-emotional and immune statuses of first-year students in various conditions of the educational process.Materials and methods: 2nd groups of first-year students of Rostov State Medical University from the medical and preventive faculty (18 people) and the military training center (17 people) were examined. They were all comparable in age (19 ±1 and 19±2 years), gender (all men), physical condition (corresponded to the I-st health group). The immune status was assessed at the Research Institute of Clinical Immunology using standard methodological approaches. Psychological testing was carried out using the Spielberger-Khanin scale, A. Beck's depression diagnostic methodology, and K. Rogers and R. Diamond questionnaire.Results: the differences in the immune response system between the compared groups were revealed only in relation to the parameters characterizing innate immunity. In relation to Medical and Preventive Faculty students, the functional capabilities of natural killers in Military Training Centre students are reduced and the expression of one of the most indicative pattern-recognizing receptors by monocytes is diminished. The analysis of the obtained data of the psychological questionnaire showed that the students of the Military Training Centredemonstrate a lower degree of situational and personal anxiety with a lower degree of adaptation in comparison with the first-year students of the Medical and Preventive Faculty.Conclusion: the immune system indicators responsible for the processes of primary immune response are reduced in military medical students comparing with medical students, which in its turn forms possible prerequisites for the development of clinical manifestations of immune dysfunction. The period of psychological adaptation to the educational process in a medical university is less successful for first-year students of the Military Training Centre. It is necessary to develop measures aimed at increasing the sense of responsibility, psychoemotional and immune adaptation resources.
Polymorphisms of interferon γ and NKG2D receptor genes in predicting vertical transmission of HIV/HCV coinfection
Authors: Khamatova A. A. , Balmasova I. P. , Chebotareva T. A. 
Published: December 2023

Objective: to investigate single nucleotide polymorphisms in IFNγ gene variant rs2430561 and in NKG2D gene variant rs2617160 as potential risk factors for mother-to-child viral transmission among HIV/HCV-coinfected women.Materials and methods: 65 mother-child pairs were examined, divided into 4 groups depending on the child's infection (HIV/ HCV infected, HIV or HCV infected, not infected). Methods: multiplex polymerase chain reaction (PCR), PCR for determining the viral load of HIV and HCV, flow cytometry for immunological studies, statistical analysis.Results: the single nucleotide polymorphism in IFNγ gene variant rs2430561 had no prognostic value when determined in the mothers. When recording the TT and AT genotypes of a single nucleotide polymorphism in this gene in a child, it was combined with the probability of the child's infection with HIV/HCV, HIV or HCV, depending on the magnitude of the viral load of HIV and HCV in the mother's blood in different trimesters of pregnancy. The presence of the AA and AT genotypes of the NKG2D gene variant rs2617160 in the mothers had a prognostic value as contributing tothe child infection with HIV/HCV or HIV alone. It was noted that the mechanisms of perinatal viral transmission included a certain level of decline in the absolute number of CD4+ lymphocytes in the woman blood in the second and third trimesters of pregnancy.Conclusions: the presence of AA and AT genotypes of the NKG2D gene variant rs2617160 in woman co-infected with HIV/HCV makes it possible to predict the risk of child infection not only during pregnancy, but also at the planning stage.
Testing Behavioral Messages to Increase Recruitment to Health Research When Embedded Within Social Media Campaigns on Twitter: Web-Based Experimental Study
Authors: Stoffel Sandro T , Law Jing Hui , Kerrison Robert , Brewer Hannah R , Flanagan James M , Hirst Yasemin 
Published: December 2023

Background
Social media is rapidly becoming the primary source to disseminate invitations to the public to consider taking part in research studies. There is, however, little information on how the contents of the advertisement can be communicated to facilitate engagement and subsequently promote intentions to participate in research.

Objective
This paper describes an experimental study that tested different behavioral messages for recruiting study participants for a real-life observational case-control study.

Methods
We included 1060 women in a web-based experiment and randomized them to 1 of 3 experimental conditions: standard advertisement (n=360), patient endorsement advertisement (n=345), and social norms advertisement (n=355). After seeing 1 of the 3 advertisements, participants were asked to state (1) their intention to take part in the advertised case-control study, (2) the ease of understanding the message and study aims, and (3) their willingness to be redirected to the website of the case-control study after completing the survey. Individuals were further asked to suggest ways to improve the messages. Intentions were compared between groups using ordinal logistic regression, reported in percentages, adjusted odds ratio (aOR), and 95% CIs.

Results
Those who were in the patient endorsement and social norms–based advertisement groups had significantly lower intentions to take part in the advertised study compared with those in the standard advertisement group (aOR 0.73, 95% CI 0.55-0.97; P=.03 and aOR 0.69, 95% CI 0.52-0.92; P=.009, respectively). The patient endorsement advertisement was perceived to be more difficult to understand (aOR 0.65, 95% CI 0.48-0.87; P=.004) and to communicate the study aims less clearly (aOR 0.72, 95% CI 0.55-0.95; P=.01). While the patient endorsement advertisement had no impact on intention to visit the main study website, the social norms advertisement decreased willingness compared with the standard advertisement group (157/355, 44.2% vs 191/360, 53.1%; aOR 0.74, 95% CI 0.54-0.99; P=.02). The majority of participants (395/609, 64.8%) stated that the messages did not require changes, but some preferred clearer (75/609, 12.3%) and shorter (59/609, 9.7%) messages.

Conclusions
The results of this study indicate that adding normative behavioral messages to simulated tweets decreased participant intention to take part in our web-based case-control study, as this made the tweet harder to understand. This suggests that simple messages should be used for participant recruitment through Twitter (subsequently rebranded X).
DPPH Scavenging Activity, Reducing Power, and Metal Chelating Capacity of Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone
Authors: Wibowo Andy Eko , Octa Ujiantari Navista Sri , Susidarti Ratna Asmah 
Published: December 2023

Background: The excessive free radicals in the body could stimulate oxidative stress which has been implicated in several diseases such as cancer, inflammation, aging, and cardiovascular diseases. The presence of antioxidants can diminish the reactivity of free radicals. The antioxidant defense system in the body may be insufficient thus intake of dietary antioxidants is recommended. Natural flavonoid such as chalcone has been known to exert several biological activities, especially antioxidant activity. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone was successfully synthesized using microwave radiation and several studies reported its biological activities such as antiinflammation, anticancer, and antibacterial activities. Those activities are thought to be related to antioxidant mechanisms. Therefore, this study aimed to evaluate its antioxidant activity. Methods: The antioxidant activities were performed with three different methods: DPPH scavenging activity, ferric reducing power, and metal chelating capacity. Results: 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone showed DPPH scavenging activity, ferric reducing power, and metal chelating capacity with IC50S values of 4,471 ± 0,052 μg/mL; 156.56 ± 4.42μg/mL; and 6,273 ± 0,025 μg/mL, respectively. Conclusions: Our results found that 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone had quite potent antioxidant activity.
Molecular Docking Study of Caffeic Acid as Acetylcholinesterase Inhibitor
Authors: Wira Waskitha Stephanus Satria , Istyastono Enade Perdana , Octa Riswanto Florentinus Dika 
Published: December 2023

Abstract: Acetylcholinesterase (AChE) receptor is a receptor that has been widely used as a potential drug target for Alzheimer's disease. Caffeic acid is a phenolic compound that had been experimentally proven to be an inhibitor of AChE. In this study, 100 molecular docking simulations were performed to study the interaction of caffeic acid in inhibiting AChE. The molecular docking simulations were performed using YASARA software with an in-house developed plug-in. Redocking results showed that there were 99 out of 100 docking poses had an RMSD value of ≤ 2.000 Å, which indicated that the molecular docking procedure could be used for further processes. The molecular docking of caffeic acid showed that all docking poses had an RMSD value of ≤ 2.000 Å relative to the best pose of the first simulation, revealing that there was only one dominant docking pose in the AChE active site. Caffeic acid interacted favorably in the AChE active site with binding energy of about -8.022 kcal/mol. Its interactions were stabilized by hydrophobic and pi-anion interactions, in which some of the interactions resemble the same interaction of the native ligand.
Keywords: Acetylcholinesterase, Alzheimer's disease, caffeic acid, molecular docking
Validación de un instrumento para medir experiencias infantiles adversas en estudiantes universitarios colombianos
Authors: Reyes-Gaspar Pedro León , Charry-Mendez Sergio 
Published: December 2023

El objetivo del presente estudio fue adaptar culturalmente y desarrollar la versión colombiana del test Adverse Childhood Experiences y explorar sus propiedades psicométricas. Metodología: participaron cinco jueces expertos para validar el contenido de la versión adaptada y 100 estudiantes universitarios para realizar la confiabilidad y validez del constructo. Resultados: El instrumento Adverse Childhood Experiences versión Colombia es autoaplicable de 16 ítems y mide cuatro factores o Subsescalas: violencia sociopolítica y desastres naturales, abusos, desafíos domésticos, y negligencia física y emocional. Esta versión mostro una muy buena validez de contenido (k=0,83-1,00), una consistencia interna fuerte y perfecta (0,95) y una validez de constructo que muestra un contenido discriminante importante de las cuatro Subsescalas o factores con el 57% de la varianza. Conclusiones: el Adverse Childhood Experiences versión colombiana es confiable para medir experiencias traumáticas en la infancia y eventos traumáticos por violencia sociopolítica y desastres naturales en población universitaria colombiana.
Orta Asya'dan Anadolu'ya yer altı kümbetleri
Authors: YILMAZ Anıl , ÇAĞLITÜTÜNCÜGİL Ersel 
Published: December 2023

Türk – İslam dünyasında yapılan kazıların sayısı arttıkça, geçmiş ile ilgili bilgilerimiz sadece tazelenmekle kalmıyor aynı zamanda çok farklı kurgular da karşımıza çıkmaya başlıyor. Bu konuda yapılan en son keşiflerden biri kaynaklarda uzun zamandır varlığı bilinen ancak bir türlü yeri tespit edilemeyen İlhanlı Sarayı oldu.
Yine akademisyenleri şaşırtan ve İlhanlı dönemine tarihlendirilen bir başka yapı da, arkeolojik çalışmalar sayesinde Kırgızistan’ın Koçkor ilçesi sınırları içinde gün yüzüne çıkarılmıştır: Kök-Taş yer altı kümbeti. Yer altında yapılan bu tip mimariler ile ilgili bilgilerimiz 1970lere kadar uzansa da, araştırmacılar bir fikir ileri sürmekten çekinmişlerdir. Ancak bugün sayısı 8’e varan kazı çalışmaları bize bu konu hakkında bir fikir vermeye başlamıştır.
Türk-İslam mimarisine Orta Asya’da katıldığı anlaşılan bu yapı tipi doğu Anadolu’ya gelen mimarlar tarafından taşınmış olmalıdır. Ancak bu kurgunun İslamiyet’e intikal etmiş Türkler tarafından değil, Moğollar tarafından geliştirildiği ileri sürülebilir. Makale, bu yapı ile ilgili kazıları tanıtmak ve bir fikir ileri sürmek üzere kurgulanmıştır.
Tarihi Yapıların Yeniden İşlevlendirme Sürecini Türkiye’den Örnekler Üzerinden Tartışmak
Authors: ÖZÇAKIR Özgün 
Published: December 2023

Kültürel miras öğesi olan tarihi yapılar, hem sosyo-kültürel hem de ekonomik değerlere sahip olup inşa edildikleri döneme ait önemli belgelerdir. Ancak tarihi yapılar, yıllar içinde toplumsal ihtiyaçların ve üretim teknolojilerinin değişim nedeniyle özgün işlevlerini kaybedebilmektedirler. Tarihi yapıların özgün işlevlerini kaybettikleri durumda “yeniden işlevlendirme”, tarihi yapıların sahip olduğu değerleri korumak ve ekonomik potansiyellerini ortaya çıkarmak için stratejik bir müdahale yaklaşımı olarak ortaya çıkmaktadır. Yeniden işlevlendirme, tarihi yapıların yeni ve çağdaş işlevler kazanarak dönüştürülmesi için gördüğü müdahale sürecini ifade etmekte olup, sürdürülebilirlik tartışmalarının günümüzde ön plana çıkması nedeniyle ilgi odağı haline gelmiş bir araştırma ve uygulama alanıdır.
Türkiye’de yeniden işlevlendirme proje ve uygulamalarına bakıldığında zengin bir deneyim söz konusudur. Türkiye’nin farklı şehirlerindeki farklı tiplere sahip ve farklı dönemlere tarihlenen yapılar; farklı müdahale stratejileri ile yeni işlevler kazanarak korunmuşlardır. Ancak, Türkiye’deki farklı örneklerin bize göstermeye çalıştığı gibi, tarihi binaların yeniden işlevlendirilmesi süreci çeşitli zorlukları da beraberinde getirir.
Yeniden işlevlendirme süreçlerini Türkiye’den örnekler üzerinden tartışmayı amaçlayan makale, “Ulusal Mimarlık Ödülleri” kapsamında “Yapı Dalı” altında Koruma-Yaşatma kategorisinde ödül alan yapıları Mimarlar Odası’nın arşiv belgeleri üzerinden inceler ve bu yapılar arasında yeniden işlevlendirilen yapıların değerlendirmesini yapar. Makale, ödül alan üç endüstri yapısının dönüşüm sürecine odaklanır (Kasımpaşa Tuz Ambarı – DDB Tuz Ambarı, Terkos Pompa İstasyonu – İstanbul Su Medeniyetleri Müzesi, Hasanpaşa Gazhanesi – MüzeGazhane) ve yeniden işlevlendirme sürecini seçilen yapılar üzerinden tartışırken, sürdürülebilir bir koruma için bütüncül yaklaşımların gerekliliğini vurgular.
Quality of sexual life in Mexican men after spinal cord injury
Authors: Acosta-Santillán Paulina Lucia , Toro-Sashida Maria Fernanda , Rosas-Mendoza Alejandra Viridiana , Fuentes-Orozco Clotilde , Jasso-García Kelvin , García de León-Flores Paulina , Mellado-Téllez Mel Paul , Ibarra-Camargo Silvia Alejandra , Chejfec-Ciociano Jonathan Matías , Barbosa-Camacho Francisco José , Flores-Prado Juan Armando , Cervantes-Guevara Gabino , Cervantes-Pérez Enrique , Cevantes-Cardona Guillermo Alonso , Alvarez-Villaseñor Andrea Socorro , González-Ojeda Alejandro 
Published: December 2023

Objective: To evaluate the quality of sexual life in men with spinal cord injury.
Design: Cross-sectional analytical study.
Patients: Males with a history of spinal cord injury who attended an outpatient rehabilitation service.
Methods: An analytical study examined adult male patients with complete spinal cord injury in rehabilitation. A modified Sexual Life Quality Questionnaire (SLQQ) examined quality of sexual life, with scores below 50 suggesting significant sexual dysfunction and dissatisfaction. The assessment evaluated age, occupation, marital status, comorbidities, and treatment methods.
Results: A total of 80 patients were included; 33 (41%) had a thoracic spinal cord injury, and 47 (59%) had a lumbar spinal cord injury. Thirty-seven patients (46%) were dissatisfied with the quality of their sexual life; 29 patients (88%) with thoracic spinal cord injury and 8 patients (17%) with lumbar spinal cord injury were dissatisfied with the quality of their sexual life (p = 0.001). Patients with higher education level experienced less sexual dissatisfaction (p = 0.03).
Conclusion: Human sexuality involves numerous interconnected elements that impact on general health. Sexual pleasure, self-esteem, and personal relationships are crucial for patients with spinal cord injury to identify rehabilitation needs. These results indicate the importance of supporting sexual well-being in recovery. Further studies of sexual enjoyment and quality of life for patients with spinal cord injury are needed, using larger and more diverse populations.
A Nerve Sheath Myxoma (Soft Tissue Myxoma) of the Lower Lip: Rare Case Study
Authors: Swaidan Rana F. 
Published: December 2023

Myxomas in the oral cavity and lips are relatively uncommon tumors that present in different types: the first type is odontogenic myxomas and the second type is soft tissue myxomas. Odontogenic myxomas (originated from the mesenchymal cells of the oral cavity such as dental papillae, periodontium, or dental follicles) are most presented in the maxilla and mandible. In comparison, soft tissue myxomas are rare in the oral cavity and lips, and only 30 cases of unknown development were reported in the literature, and only five cases involving the lip were reported. Even if it is considered very rare, nerve sheath (soft tissue) myxoma must be included in the differential diagnosis of lip lesions and excised widely to prevent local recurrence. The aim of our case study is to present a rare case of lip myxoma in a male patient 26-year-old who presented with a soft, exophytic lesion on the lower lip.
Перспективи розвитку ринку органічних добрив в Україні
Authors: Червоний Дмитро 
Published: December 2023

Ринок органічних добрив є особливо важливим для України, тому що його ефективне функціонування має першочергове значення для забезпечення продовольчої, екологічної та енергетичної безпеки держави, з одного боку, та біоекономічної фундаментальної складової, з іншого боку, у зв’язку з тим, що Україна сьогодні є одним з найбільших гравців на світовому ринку продовольства, займаючи лідируючі позиції за обсягами експорту сільськогосподарської продукції. Отже, розвиток ринку органічних добрив, в умовах невпинного зростання вартості мінеральних добрив та дедалі гострішої їх нестачі в Україні, вимагає пошуку шляхів підвищення рівня забезпечення щорічно зростаючих потреб сільськогосподарських підприємств щодо забезпечення рослин поживними речовинами. З огляду на це, особливої актуальності набувають аналіз тенденцій сучасного стану ринку та визначення перспектив його розвитку.
У статті охарактеризовано сучасний стан ринку органічних добрив. Сформульовано основні напрями його розвитку. Визначено проблемні питання, які потребують вирішення задля позитивного розвитку та функціонування ринку органічних добрив в Україні. Обґрунтовано рекомендації та організаційно-правові, методичні підходи до розвитку ринку органічних добрив.
Ключові слова: ринок, органічні добрива, виробництво, інноваційна технологія, ефективність, сировина, площа, урожайність.
Проблеми та перспективи реформування ООН: позиція України
Authors: Грачевська Таміла , Гірман Алла 
Published: December 2023

Статтю присвячено аналізу позиції України щодо потенційних шляхів реформування ООН у період її функціонування на міжнародній арені як незалежної держави. Особливу увагу приділено розгляду причин необхідності реформування ООН; визначенню головних напрямів здійснення докорінних змін у практиці функціонування інститутів ООН (Ради Безпеки ООН, особливостей застосування права вето); характеристиці поглядів українських дипломатів на можливості та перешкоди на шляху реформування ООН; дослідженню позиції України щодо реформування провідних напрямів діяльності ООН, зокрема миротворчої діяльності.
Ключові слова: Рада Безпеки ООН, Генеральна Асамблея ООН, право вето, миротворча діяльність, багатостороння дипломатія, резолюція, постійний представник.
Методичний підхід до аналізу та оцінки підприємницького потенціалу підприємства
Authors: Ковальська Любов , Левчук Іван , Левчук Олег 
Published: December 2023

Мета статті – висвітлення авторського методичного підходу до аналізу та оцінки підприємницького потенціалу підприємства. Здійснено огляд методичних підходів до аналізу та оцінки зазначеного потенціалу, що показав наявність значної кількості методів та системи показників.
У статті представлено авторський методичний підхід до аналізу та оцінки підприємницького потенціалу, що містить такі елементи, як: мета, завдання, об’єкт та суб’єкт оцінки підприємницького потенціалу, інформаційна база дослідження підприємницького потенціалу, методи дослідження підприємницького потенціалу, напрями дослідження підприємницького потенціалу, показники оцінки підприємницького потенціалу за напрямами, інтегральна оцінка підприємницького потенціалу підприємства, виявлення резервів нарощення підприємницького потенціалу.
Запропоновано систему показників за напрямами оцінки підприємницького потенціалу підприємства: інтелектуальний потенціал, маркетинговий потенціал, фінансовий потенціал, інноваційний потенціал, інформаційний потенціал, виробничий потенціал, креативний потенціал. Обґрунтовано необхідність розрахунку інтегрального індексу підприємницького потенціалу підприємства.
Ключові слова: підприємницький потенціал, аналіз та оцінка, методичний підхід, показники, індекс, методи, інтелектуальний потенціал, маркетинговий потенціал, фінансовий потенціал, інноваційний потенціал, інформаційний потенціал, виробничий потенціал, креативний потенціал.