bluuebunny/crossref_metadata_2025_split huggingface dataset:
ISO Certification, Firm Characteristics and Carbon Emission Disclosure
Authors: Chariri A. , Januarti I. , Yuyetta E. N. A. 
Published: October 2023

Abstract
Companies’ activities have contributed to the increase in carbon emissions, which lead to the negative impact on the environment. This phenomenon has motivated companies to voluntarily disclose carbon emission disclosure. Considering this disclosure issues, our study aims to investigate the effect of ISO certification, type of industry, profitability, and firm size on carbon emission disclosure. The population consists of companies listed in the Carbon Disclosure Project (CDP) of Nordic with total sample of 131 companies. Data were then analyzed using a multiple linear regression. The findings showed that profitability and firm size positive effect on carbon emission disclosure. Meanwhile, ISO certification and type of industry had no effect on carbon emission disclosure. This implied that ISO certification is seen as a symbolic strategy of carbon emission management.
The Dilem Wilis Agro Tourism Community’s Development Using the Sociopreneurship Model to Achieve Sustainable Tourism Development
Authors: Putri D. M. , Sayono J. , Ridhoi R. , Thoriquttyas T. 
Published: October 2023

Abstract
Tourism development is required to maintain sustainability and environmental ecosystem preservation while taking into account the socio-cultural conditions of the local population, so that it may be maintained and enjoyed by future generations. The ability of society to manage tourism potential is a fundamental point in maintaining the tourism business. Society acts as a host with the resources they have, both in the form of customs, traditions, and culture. One of the development models that can be applied to society is sociopreneurship. Through this model, people not only think for themselves but also for others and the environment around them. This study aims to examine the potential implementation of the sociopreneurship model in the development of the Dillem Wilis Agrotourism community, Trenggalek Regency. The method used is qualitative. The data source from this study came from key informants, the Dillem Wilis Agrotourism society. Determination of respondents in this study by means of snowball sampling. Data collection techniques used in-depth interviews, observation, and documentation. The data analysis used is data reduction, data presentation, and drawing conclusions. Based on the study’s results, it can be concluded that the sociopreneurship model can be well received by the Dillem Wilis Agrotourism Society. Through sociopreneurship community involvement in tourism development can be maximized in line with the realization of Sustainable Tourism Development.
Capturing the Opportunity of Green Economic Policy for Environmental Sustainability
Authors: Rodiyah R , Arifin R , Wulansarie R , Baiquni M I , Zainurohmah Z 
Published: October 2023

Abstract
This research paper focuses on the concept of green economics policy as a means to achieve environmental sustainability. The paper begins by defining green economics policy as an approach that promotes sustainable economic growth while also protecting the environment. It argues that a shift towards a green economy is necessary to address the current environmentalchallenges facing the planet. The paper examines the key elements of a green economics policy,which include promoting renewable energy sources, investing in sustainable infrastructure, supporting sustainable agriculture practices, and incentivizing businesses to adopt environmentally friendly practices. The paper highlights the importance of policy coherence and coordination across different sectors and levels of government to ensure a successful transition to a green economy. The research also discusses the potential benefits of a green economics policy, such as the creation of green jobs, the reduction of greenhouse gas emissions, and improved public health outcomes. The paper emphasizes the importance of engaging stakeholders in the policymaking process, including civil society organizations, businesses, and affected communities, to ensure that the policy is equitable and socially just. The paperconcludes by highlighting the urgent need for governments to adopt green economics policies to address the environmental crisis. It emphasizes the importance of international cooperation tosupport countries in transitioning to a green economy and the need for innovative financing mechanisms to support sustainable development. The paper argues that a green economics policy offers a viable path towards achieving environmental sustainability while also promoting economic growth and social equity.
Performance and mechanisms of active attapulgite-supported sulfidated nanoscale zero-valent iron materials for Pb(II) removal from aqueous solution
Authors: Song Xiaosan , Song Xichen , Dai Liang 
Published: October 2023

Abstract
To inhibit the oxidation, passivation, and agglomeration of nano-zero-valent iron (nZVI), a liquid phase reduction method was used to load sulfurized nZVI onto acid-modified ATP with attapulgite (ATP) as the carrier (S-nZVI@ATP). The performance and mechanism of this material were studied for Pb2+ removal in water. The S-nZVI@ATP preparation prevents the agglomeration of nZVI particles and reduces nZVI oxidation. Pb2+ removal proceeds efficiently and stably when using S-nZVI@ATP at pH values ranging from 2.5–5.5. According to the electron sharing and transfer-based pseudo-second-order kinetic model, the Pb2+ is adsorbed onto S-nZVI@ATP, and the speed control step is completed by liquid film diffusion and intraparticle diffusion. The S-nZVI@ATP mediated Pb2+ adsorption is well-described by Freundlich’s isothermal adsorption model, which is a multilayer chemical adsorption process. The temperature and initial Pb2+ concentration were varied, and it was determined that Pb2+ adsorbs on S-nZVI@ATP in an endothermic reaction. This S-nZVI@ATP composite material has high reducibility, high surface activity, and good adsorption properties for Pb2+. Tests were performed for 24 h using adsorbent (1 g l−1) in Pb2+ solution (30 ml). For an initial Pb2+ concentration of 700 mg l−1, S−1-nZVI@ATP removes 57.37% of the Pb2+ and has an adsorption capacity of 401.60 mg g−1. In addition to forming PbS and Pb(OH)2 precipitates, Pb2+ also complexes with the Fe/H oxide shell of S-nZVI@ATP, and Fe0 reduces some Pb2+ on the nZVI to Pb0. The results exhibited that S-nZVI@ATP has excellent potential as an adsorbent for the removal of Pb2+ from the industrial wastewater.
Effect of microstructural characteristics on the impact fracture behavior of cryogenic 9Ni steel
Authors: Zhang Hongliang , Li Xinling , Zhao Qibin , Hou Jiaping , Zhang Dazheng , Xu Jiakai , Li Weijuan 
Published: October 2023

Abstract
The percentage of shear fracture largely determines the service performance of 9Ni steel used in low-temperature pressure vessels. Through elemental analysis, microstructural characterization, and mechanical property tests, this study investigates why the percentage of shear fractures is low in 9Ni steel and clarifies the mechanism by which the microstructural characteristics influence the low-temperature impact behavior of 9Ni steel. It was found that cleavage fracture zones, formed when segregation bands appear in the microstructure, decrease the percentage of shear fractures at the impact fracture surface. Specifically, as the segregation area increases from 0.9% to 7.1%, the shear-fracture percentage in 9Ni steel sharply decreases from 100% to 65%, accompanied by a deterioration in low-temperature toughness. The segregation zone is enriched in austenite-forming elements (Ni, C, Mn), leading to a tempered martensite microstructure with a lath shape. The small number of high-angle grain boundaries and low interface bonding strength cannot effectively prevent crack initiation and propagation, resulting in brittle cleavage fracture. In contrast, the non-segregated zone is tempered sorbite with a uniform structure, several high-angle grain boundaries, and a high interface bonding strength. These features hinder crack initiation and propagation. Furthermore, the shear-fracture zone generated in the non-segregated zone exhibits ductile fracture characteristics.
T-cell large granular lymphocytic leukemia in Vietnam: Using microscope-to-screen videoconferencing to improve diagnosis
Authors: Dayton Vanessa J , Thien Dang Hoang , Ngon Huynh Thien , Arries Cade , Sang Nguyen Ngoc , Lien Nguyen Phuong , Kinder Scott , Dung Phu Chi 
Published: October 2023

Abstract

Objectives
Leukemia diagnosis in Vietnam is limited by a lack of hematopathology training and expert consultation as well as the cost of high-magnification digitization of hematology slides. Screen-sharing software allows international collaboration with experienced hematopathologists for improved diagnostic accuracy.

Methods
A hematopathology education and consultation program was proposed for Vietnam hospitals. By appointment, pathologists in Vietnam with access to a microscope camera, imaging software, and high-speed internet were invited to review slides and data with a volunteer board-certified hematopathologist in the United States using secure videoconferencing software. A single hospital in southern Vietnam assigned a pathologist proficient in English to access this service. All consultations from this site with clinicopathologic information were logged. After a 2-year period of online consultation, case slides for selected diagnoses were reviewed under the microscope in Vietnam to assess concordance.

Results
In total, 135 consultations were logged, 53 of which were for blood and bone marrow. T-cell large granular lymphocytic leukemia (T-LGLL) was 1 of the most frequent bone marrow consultation-related diagnoses; all diagnoses of this entity were confirmed by in-person microscopy (100% concordance). A records search and physician surveys found no prior documented diagnoses of T-LGLL made in Vietnam before this education and consultation program.

Conclusions
Our virtual consultation model has improved patient care in Vietnam by providing correct diagnoses to inform best practices in treatment. As a result of our program, the first Vietnam diagnoses of T-LGLL were made and may help expand on the literature in this area. This model could provide cost-effective, real-time consultation and education services for pathologists in underserved communities.
The five pillars of computational reproducibility: bioinformatics and beyond
Authors: Ziemann Mark , Poulain Pierre , Bora Anusuiya 
Published: October 2023

Abstract
Computational reproducibility is a simple premise in theory, but is difficult to achieve in practice. Building upon past efforts and proposals to maximize reproducibility and rigor in bioinformatics, we present a framework called the five pillars of reproducible computational research. These include (1) literate programming, (2) code version control and sharing, (3) compute environment control, (4) persistent data sharing and (5) documentation. These practices will ensure that computational research work can be reproduced quickly and easily, long into the future. This guide is designed for bioinformatics data analysts and bioinformaticians in training, but should be relevant to other domains of study.
Surfaces: a software to quantify and visualize interactions within and between proteins and ligands
Authors: Teruel Natália , Borges Vinicius Magalhães , Najmanovich Rafael 
Published: October 2023

Abstract

Summary
Computational methods for the quantification and visualization of the relative contribution of molecular interactions to the stability of biomolecular structures and complexes are fundamental to understand, modulate and engineer biological processes. Here, we present Surfaces, an easy to use, fast and customizable software for quantification and visualization of molecular interactions based on the calculation of surface areas in contact. Surfaces calculations shows equivalent or better correlations with experimental data as computationally expensive methods based on molecular dynamics.

Availability and implementation
All scripts are available at https://github.com/NRGLab/Surfaces. Surface’s documentation is available at https://surfaces-tutorial.readthedocs.io/en/latest/index.html.
Risk of Cancer in Patients With Crohn’s Disease 30 Years After Diagnosis (the IBSEN Study)
Authors: Follin-Arbelet Benoit , Cvancarova Småstuen Milada , Hovde Øistein , Jelsness-Jørgensen Lars-Petter , Moum Bjørn 
Published: October 2023

Abstract

Background
Patients with Crohn’s disease (CD) are most often diagnosed as young adults; therefore, long-term studies are needed to assess the risk of cancer over their lifetime. Thus, the aims of the present study were to determine the risk of cancer in a Norwegian population-based cohort (the Inflammatory Bowel South Eastern Norway [IBSEN] study), 30 years after diagnosis, and to assess whether patients with CD were at an increased risk of specific cancer types.

Methods
The IBSEN cohort prospectively included all incident patients diagnosed between 1990 and 1993. Data on cancer incidence were obtained from the Cancer Registry of Norway. Overall and cancer-specific hazard ratios (HRs) for CD patients compared with age- and sex-matched controls were modeled using Cox regression. Standardized incidence ratios (SIRs) were estimated compared to the general population.

Results
In total, the cohort included 237 patients with CD, and 36 of them were diagnosed with cancer. Compared to the general Norwegian population, patients with CD had an increased overall risk of cancer (HR = 1.56, 95% CI: 1.06–2.28), particularly male patients (HR = 1.85, 95% CI: 1.08–3.16). The incidence of lung cancer and nonmelanoma skin cancer was increased; however, the difference was not statistically significant (SIR = 2.29, 95% CI: 0.92–4.27 and SIR = 2.45, 95% CI: 0.67–5.37, respectively).

Conclusions
After 30 years of follow-up, the risk of all cancers in patients with CD was increased compared to the general population.
Misclassification of females and males in cardiovascular magnetic resonance parametric mapping: the importance of sex-specific normal ranges for diagnosis of health vs. disease
Authors: Thomas Katharine E , Lukaschuk Elena , Shanmuganathan Mayooran , Kitt Jamie A , Popescu Iulia A , Neubauer Stefan , Piechnik Stefan K , Ferreira Vanessa M 
Published: October 2023

Abstract

Aims
Cardiovascular magnetic resonance parametric mapping enables non-invasive quantitative myocardial tissue characterization. Human myocardium has normal ranges of T1 and T2 values, deviation from which may indicate disease or change in physiology. Normal myocardial T1 and T2 values are affected by biological sex. Consequently, normal ranges created with insufficient numbers of each sex may result in sampling biases, misclassification of healthy values vs. disease, and even misdiagnoses. In this study, we investigated the impact of using male normal ranges for classifying female cases as normal or abnormal (and vice versa).

Methods and results
One hundred and forty-two healthy volunteers (male and female) were scanned on two Siemens 3T MR systems, providing averaged global myocardial T1 and T2 values on a per-subject basis. The Monte Carlo method was used to generate simulated normal ranges from these values to estimate the statistical accuracy of classifying healthy female or male cases correctly as ‘normal’ when using sex-specific vs. mixed-sex normal ranges. The normal male and female T1- and T2-mapping values were significantly different by sex, after adjusting for age and heart rate.

Conclusion
Using 15 healthy volunteers who are not sex specific to establish a normal range resulted in a typical misclassification of up to 36% of healthy females and 37% of healthy males as having abnormal T1 values and up to 16% of healthy females and 12% of healthy males as having abnormal T2 values. This paper highlights the potential adverse impact on diagnostic accuracy that can occur when local normal ranges contain insufficient numbers of both sexes. Sex-specific reference ranges should thus be routinely adopted in clinical practice.
Instantaneous detection of acute myocardial infarction and ischaemia from a single carotid pressure waveform in rats
Authors: Alavi Rashid , Dai Wangde , Matthews Ray V , Kloner Robert A , Pahlevan Niema M 
Published: October 2023

AbstractAimsMyocardial infarction (MI) is one of the leading causes of death worldwide. It is well accepted that early diagnosis followed by early reperfusion therapy significantly increases the MI survival. Diagnosis of acute MI is traditionally based on the presence of chest pain and electrocardiogram (ECG) criteria. However, around 50% of the MIs are without chest pain, and ECG is neither completely specific nor definitive. Therefore, there is an unmet need for methods that allow detection of acute MI or ischaemia without using ECG. Our hypothesis is that a hybrid physics-based machine learning (ML) method can detect the occurrence of acute MI or ischaemia from a single carotid pressure waveform.Methods and resultsWe used a standard occlusion/reperfusion rat model. Physics-based ML classifiers were developed using intrinsic frequency parameters extracted from carotid pressure waveforms. ML models were trained, validated, and generalized using data from 32 rats. The final ML models were tested on an external stratified blind dataset from additional 13 rats. When tested on blind data, the best ML model showed specificity = 0.92 and sensitivity = 0.92 for detecting acute MI. The best model’s specificity and sensitivity for ischaemia detection were 0.85 and 0.92, respectively.ConclusionWe demonstrated that a hybrid physics-based ML approach can detect the occurrence of acute MI and ischaemia from carotid pressure waveform in rats. Since carotid pressure waveforms can be measured non-invasively, this proof-of-concept pre-clinical study can potentially be expanded in future studies for non-invasive detection of MI or myocardial ischaemia.
Soluble urokinase Plasminogen Activator Receptor (suPAR) mediates the effect of a lower education level on adverse outcomes in patients with coronary artery disease
Authors: Füller David , Liu Chang , Ko Yi-An , Alkhoder Ayman A , Desai Shivang R , Almuwaqqat Zakaria , Patel Shivani A , Ejaz Kiran , Kauser Tanveer , Martini Mohamed Afif , Alvi Zain , Mehta Puja K , Sperling Laurence S , Quyyumi Arshed A 
Published: October 2023

Abstract

Aims
To investigate whether the adverse impact of lower educational attainment on mortality risk in patients with coronary artery disease (CAD) is mediated by the activation of inflammatory and immune pathways, estimated as elevated soluble urokinase plasminogen activator receptor levels.

Methods and results
In 3164 patients undergoing coronary angiography, we investigated multivariable associations between suPAR and educational attainment and assessed the relationship between a lower educational level (defined as a high-school degree or less as the highest educational qualification) and outcomes using Cox proportional hazard and Fine and Gray’s subdistribution competing risk models. The potential mediating effect through suPAR and high-sensitivity C-reactive protein (hs-CRP) was assessed using mediation analysis. A total of 1814 patients (57.3%) had achieved a higher (≥college) education level and 1350 patients (42.7%) a lower (≤high school) education level. Soluble urokinase plasminogen activator receptor levels were 9.0% [95% confidence interval (CI) 6.3–11.8, P ≤ 0.0001] higher in patients with lower educational qualifications than in those with higher educational qualifications after covariate adjustment. Lower educational attainment was associated with a higher risk of cardiovascular death after adjustment for demographic, clinical, and behavioural covariates, including CAD severity and heart failure history, medication use, and hs-CRP levels [hazard ratio 1.26 (95% CI 1.02–1.55, P = 0.03)]. However, after adjustment for suPAR levels, the effect of a lower educational level on cardiovascular death became insignificant. Values were similar for all-cause death. Soluble urokinase plasminogen activator receptor levels mediated 49% and hs-CRP levels 17% of the cardiovascular death risk attributable to lower educational attainment.

Conclusion
Circulating suPAR levels importantly mediate the effects of lower educational attainment on mortality, indicating the importance of systemic inflammation and immune dysregulation as biologic mediators of adverse social determinants of health.
The Effects of Midlife Acute and Chronic Stressors on Black–White Differences in Cognitive Decline
Authors: Mitchell Uchechi A , Shaw Benjamin A , Torres Jacqueline M , Brown Lauren L , Barnes Lisa L 
Published: October 2023

Abstract

Objectives
Midlife stressors may be particularly consequential for cognitive performance and disparities in cognitive decline. This study examined Black–White differences in trajectories of cognition among middle-aged adults and the effects of acute and chronic stressors on these trajectories.

Methods
Data come from 4,011 cognitively healthy individuals aged 51–64 (620 Black and 3,391 White) who participated in the 2006–2018 waves of the Health and Retirement Study. Stressors included a count of recent life events and measures of financial strain and everyday discrimination. Global cognition was assessed using a modified version of the Telephone Interview for Cognitive Status. Linear mixed models with random slopes and intercepts assessed change in cognition over time. Race-by-time, race-by-stressor, time-by-stressor, and race-by-stressor-by-time interactions were assessed as were quadratic terms for time and each stressor.

Results
After adjusting for sociodemographic, health behaviors, and health-related factors, Black respondents had lower initial cognitive performance scores (b = −1.75, p &lt; .001) but experienced earlier but slower decline in cognitive performance over time (Black × Time2 interaction: b = 0.02, p &lt; .01). Financial strain, discrimination, and recent life events each had distinct associations with cognitive performance but did not influence racial differences in levels of or change in cognition over time.

Discussion
Middle-aged Black adults have lower initial cognition levels and experience earlier but less accelerated cognitive decline compared to White middle-aged adults. Midlife acute and chronic stressors influence baseline cognition but do so in different ways. Future research should examine the influence of other stressors on racial differences in cognitive decline at other points in the life course.