bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats
Authors: Ibos Katalin Eszter , Bodnár Éva , Dinh Hoa , Kis Merse , Márványkövi Fanni , Kovács Zsuzsanna Z. A. , Siska Andrea , Földesi Imre , Galla Zsolt , Monostori Péter , Szatmári István , Simon Péter , Sárközy Márta , Csabafi Krisztina 
Published: November 2023

AbstractChronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study was to assess the effect of moderate CKD on anxiety in rats. 5/6 nephrectomy was performed in male Wistar rats. 7 weeks after, anxiety-like behavior was assessed by elevated plus maze (EPM), open field (OF), and marble burying (MB) tests. At weeks 8 and 9, urinalysis was performed, and blood and amygdala samples were collected, respectively. In the amygdala, the gene expression ofAvpand the gene and protein expression ofCrh,Crhr1, andCrhr2were analyzed. Furthermore, the plasma concentration of corticosterone, uremic toxins, and tryptophan metabolites was measured by UHPLC-MS/MS. Laboratory tests confirmed the development of CKD. In the CKD group, the closed arm time increased; the central time and the total number of entries decreased in the EPM. There was a reduction in rearing, central distance and time in the OF, and fewer interactions with marbles were detected during MB. CKD evoked an upregulation of gene expression ofCrh,Crhr1, andCrhr2, but notAvp, in the amygdala. However, there was no alteration in protein expression. In the CKD group, plasma concentrations of p-cresyl-sulfate, indoxyl-sulfate, kynurenine, kynurenic acid, 3-hydroxykynurenine, anthranilic acid, xanthurenic acid, 5-hydroxyindoleacetic acid, picolinic acid, and quinolinic acid increased. However, the levels of tryptophan, tryptamine, 5-hydroxytryptophan, serotonin, and tyrosine decreased. In conclusion, moderate CKD evoked anxiety-like behavior that might be mediated by the accumulation of uremic toxins and metabolites of the kynurenine pathway, but the contribution of the amygdalar CRH system to the development of anxiety seems to be negligible at this stage.
The role of the multidisciplinary tumor board after endoscopic resection of malignant tumors: is it worth it?
Authors: Kouladouros Konstantinos , Centner Maximilian , Reissfelder Christoph , Belle Sebastian , Kähler Georg 
Published: November 2023

Abstract
Objectives
The value of multidisciplinary tumor boards (MTBs) in the treatment of gastrointestinal cancer patients is well known. Most of the current evidence focuses on advanced cancer cases, whereas little is known about the effect of MTBs on early tumors, especially after endoscopic resection. The aim of our study is to evaluate the value of the MTB after endoscopic resection of malignant tumors of the gastrointestinal tract.

Methods
We retrospectively analyzed all endoscopically resected malignant tumors in our department between 2011 and 2019, focusing on the existence of an MDT recommendation after endoscopic resection, the MDT adherence to the current guidelines, and the implementation of the recommendation by the patients.

Results
We identified 198 patients fulfilling our inclusion criteria, of whom 168 (85%) were discussed in the MDT after endoscopic resection. In total, 155 of the recommendations (92%) were in accordance with the current guidelines, and 147 (88%) of them were implemented by the patients. The MDT discussion itself did not influence the overall survival, whereas the implementation of the MTB recommendation was associated with a significantly better prognosis. Deviations of the MDT recommendation from the guidelines had no effect on the overall survival.

Conclusions
The discussion of endoscopically resected malignant tumors in the MTB is crucial for the treatment of patients with this type of cancer, since the implementation of the MTB recommendation, even if it deviates from the current guidelines, improves the prognosis.
Surrogate-assisted hyper-parameter search for portfolio optimisation: multi-period considerations
Authors: van Zyl Terence L. , Woolway Matthew , Paskaramoorthy Andrew 
Published: November 2023

AbstractPortfolio management is a multi-period multi-objective optimisation problem subject to various constraints. However, portfolio management is treated as a single-period problem partly due to the computationally burdensome hyper-parameter search procedure needed to construct a multi-period Pareto frontier. This study presents the Pareto driven surrogate (ParDen-Sur) modelling framework to efficiently perform the required hyper-parameter search. ParDen-Sur extends previous surrogate frameworks by including a reservoir sampling-based look-ahead mechanism for offspring generation in evolutionary algorithms (EAs) alongside the traditional acceptance sampling scheme. We evaluate this framework against, and in conjunction with, several seminal multi-objective (MO) EAs on two datasets for both the single- and multi-period use cases. When considering hypervolume ParDen-Sur improves marginally (0.8%) over the state-of-the-art (SOTA)-NSGA-II. However, for generational distance plus and inverted generational distance plus, these improvements over the SOTA are 19.4% and 66.5%, respectively. When considering the average number of evaluations and generations to reach a 99% success rate, ParDen-Sur is shown to be 1.84× and 2.02× more effective than the SOTA. This improvement is statistically significant for the Pareto frontiers, across multiple EAs, for both datasets and use cases.
Sunshine and solar power in the UK
Authors: Spellman Greg , Bird Danielle 
Published: November 2023

AbstractSolar power is an increasingly important source of clean energy even for a relatively cloudy mid-latitude nation such as the UK. Using areal sunshine series published by the UK Met Office, this study describes the continuing brightening trend that has also been observed since the mid-1980s around the world. The use of the automated Lamb weather type system is explored, particularly the surface synoptic indices developed by Jenkinson and Collison. There is a strong association between sunshine duration (via cloudiness) and circulation features such as anticyclonicity; however, there is no surface-level circulation trend observed that can explain the brightening.
Change in emotional distress, anxiety, depression and PTSD from pre- to post-flood exposure in women residing in low-income settings in South Africa
Authors: Nöthling J. , Gibbs A. , Washington L. , Gigaba S. G. , Willan S. , Abrahams N. , Jewkes R. 
Published: November 2023

AbstractFloods are increasing in frequency and may increase the risk for experiencing emotional distress, anxiety, depression and PTSD. The aim of this study was to determine the extent of damage, loss, injury and death resulting from floods that occurred in and around the city of Durban, South Africa, in April 2022, and associated changes in mental health pre- to post-floods in a low-income setting. Seventy-three women between the ages of 18 and 45, residing in flood affected, low-income settings, were interviewed prior to the floods occurring. Mental health measures were repeated with 69 of the 73 women during the post-flood interview along with a questionnaire measuring flood-related exposures. Loss of infrastructure (lacked access to drinking water, electricity, fresh food, could not travel to work, had to stay in a shelter and could not get hold of friends or family) was a predictor of post-flood change in levels of emotional distress and anxiety. Higher levels of prior trauma exposure were associated with higher post-flood levels of emotional distress. Higher pre-flood food insecurity was also associated with higher post-flood anxiety. Women affected by poverty, food insecurity and a history of trauma are vulnerable to the additive adverse mental health effects of floods. Proactive approaches to diminishing the impact of floods on the livelihood of women is needed and post-flood relieve efforts may be more affective if they are enhanced by providing mental health support.
A survey on the evolution of stream processing systems
Authors: Fragkoulis Marios , Carbone Paris , Kalavri Vasiliki , Katsifodimos Asterios 
Published: November 2023

AbstractStream processing has been an active research field for more than 20 years, but it is now witnessing its prime time due to recent successful efforts by the research community and numerous worldwide open-source communities. This survey provides a comprehensive overview of fundamental aspects of stream processing systems and their evolution in the functional areas of out-of-order data management, state management, fault tolerance, high availability, load management, elasticity, and reconfiguration. We review noteworthy past research findings, outline the similarities and differences between the first (’00–’10) and second (’11–’23) generation of stream processing systems, and discuss future trends and open problems.
Utility of exome sequencing for the diagnosis of pediatric-onset neuromuscular diseases beyond diagnostic yield: a narrative review
Authors: Piñeros-Fernández Martha Cecilia , Morte Beatriz , García-Giménez José Luis 
Published: November 2023

AbstractDiagnosis of neuromuscular diseases (NMD) can be challenging because of the heterogeneity of this group of diseases. This review aimed to describe the diagnostic yield of whole exome sequencing (WES) for pediatric-onset neuromuscular disease diagnosis, as well as other benefits of this approach in patient management since WES can contribute to appropriate treatment selection in NMD patients. WES increases the possibility of reaching a conclusive genetic diagnosis when other technologies have failed and even exploring new genes not previously associated with a specific NMD. Moreover, this strategy can be useful when a dual diagnosis is suspected in complex congenital anomalies and undiagnosed cases.
Searching for long faint astronomical high energy transients: a data driven approach
Authors: Crupi Riccardo , Dilillo Giuseppe , Bissaldi Elisabetta , Ward Kester , Fiore Fabrizio , Vacchi Andrea 
Published: November 2023

AbstractHERMES Pathfinder is an in-orbit demonstration consisting of a constellation of six 3U nano-satellites hosting simple but innovative detectors for the monitoring of cosmic high-energy transients. The main objective of HERMES Pathfinder is to prove that accurate position of high-energy cosmic transients can be obtained using miniaturized hardware. The transient position is obtained by studying the delay time of arrival of the signal to different detectors hosted by nano-satellites on low-Earth orbits. In this context, we need to develop novel tools to fully exploit the future scientific data output of HERMES Pathfinder. In this paper, we introduce a new framework to assess the background count rate of a spaceborne, high energy detector; a key step towards the identification of faint astrophysical transients. We employ a neural network to estimate the background lightcurves on different timescales. Subsequently, we employ a fast change-point and anomaly detection technique called Poisson-FOCuS to identify observation segments where statistically significant excesses in the observed count rate relative to the background estimate exist. We test the new software on archival data from the NASA Fermi Gamma-ray Burst Monitor (GBM), which has a collecting area and background level of the same order of magnitude to those of HERMES Pathfinder. The neural network performances are discussed and analyzed over period of both high and low solar activity. We were able to confirm events in the Fermi-GBM catalog, both solar flares and gamma-ray bursts, and found events, not present in Fermi-GBM database, that could be attributed to solar flares, terrestrial gamma-ray flashes, gamma-ray bursts and galactic X-ray flashes. Seven of these are selected and further analyzed, providing an estimate of localisation and a tentative classification.
Systematic Review to Inform a World Health Organization (WHO) Clinical Practice Guideline: Benefits and Harms of Needling Therapies for Chronic Primary Low Back Pain in Adults
Authors: Yu Hainan , Wang Dan , Verville Leslie , Southerst Danielle , Bussières André , Gross Douglas P. , Pereira Paulo , Mior Silvano , Tricco Andrea C. , Cedraschi Christine , Brunton Ginny , Nordin Margareta , Shearer Heather M. , Wong Jessica J. , Connell Gaelan , Myrtos Danny , da Silva-Oolup Sophia , Young James J. , Funabashi Martha , Romanelli Andrew , Lee Joyce G. B. , Stuber Kent , Guist Brett , Muñoz Laguna Javier , Hofstetter Léonie , Murnaghan Kent , Hincapié Cesar A. , Cancelliere Carol 
Published: November 2023

Abstract
Purpose
Evaluate benefits and harms of needling therapies (NT) for chronic primary low back pain (CPLBP) in adults to inform a World Health Organization (WHO) standard clinical guideline.

Methods
Electronic databases were searched for randomized controlled trials (RCTs) assessing NT compared with placebo/sham, usual care, or no intervention (comparing interventions where the attributable effect could be isolated). We conducted meta-analyses where indicated and graded the certainty of evidence.

Results
We screened 1831 citations and 109 full text RCTs, yeilding 37 RCTs. The certainty of evidence was low or very low across all included outcomes. There was little or no difference between NT and comparisons across most outcomes; there may be some benefits for certain outcomes. Compared with sham, NT improved health-related quality of life (HRQoL) (physical) (2 RCTs; SMD = 0.20, 95%CI 0.07; 0.32) at 6 months. Compared with no intervention, NT reduced pain at 2 weeks (21 RCTs; MD = − 1.21, 95%CI − 1.50; − 0.92) and 3 months (9 RCTs; MD = − 1.56, 95%CI − 2.80; − 0.95); and reduced functional limitations at 2 weeks (19 RCTs; SMD = − 1.39, 95%CI − 2.00; − 0.77) and 3 months (8 RCTs; SMD = − 0.57, 95%CI − 0.92; − 0.22). In older adults, NT reduced functional limitations at 2 weeks (SMD = − 1.10, 95%CI − 1.71; − 0.48) and 3 months (SMD = − 1.04, 95%CI − 1.66; − 0.43). Compared with usual care, NT reduced pain (MD = − 1.35, 95%CI − 1.86; − 0.84) and functional limitations (MD = − 2.55, 95%CI − 3.70; − 1.40) at 3 months.

Conclusion
Based on low to very low certainty evidence, adults with CPLBP experienced some benefits in pain, functioning, or HRQoL with NT; however, evidence showed little to no differences for other outcomes.
Scope, content and quality of clinical pharmacy practice guidelines: a systematic review
Authors: Paudyal Vibhu , Okuyan Betul , Henman Martin Charles , Stewart Derek , Fialová Daniela , Hazen Ankie , Lutters Monika , Oleárová Anna , Weidmann Anita E. , Wirth Francesca , Cadogan Cathal A. , Nazar Zachariah 
Published: November 2023

Abstract
Background
Guidelines for pharmacy practitioners regarding various clinical pharmacy activities have been published in a number of countries. There is a need to review the guidelines and identify the scope of activities covered as a prelude to developing internationally acceptable common guidelines.

Aim
To review the scope of clinical pharmacy guidelines and assess the extent to which these guidelines conform to quality standards as per the AGREE II instrument.

Method
Medline, Embase, Guideline Central, International Pharmaceutical Abstracts, Google Scholar and Google (for grey literature) were searched for the period 2010 to January 2023. Guidelines which focused on any health care setting and any clinical pharmacy activity were included. Data were extracted and quality assessed independently by two reviewers using the English version of the AGREE II instrument.

Results
Thirty-eight guidelines were included, mostly originating from Australia (n = 10), Ireland (n = 8), UK (n = 7) and USA (n = 5). Areas covered included medication reconciliation, medicines optimisation, medication management and transition of care. As per the AGREE II assessment, the highest score was obtained for the scope and purpose domain and the lowest score for rigour of development, mainly due to non-consideration of literature/evidence to inform guideline development.

Conclusion
Clinical pharmacy guidelines development processes need to focus on all quality domains and should take a systematic approach to guideline development. Guidelines need to further emphasise person-centred care and clinical communication. There is a scope to harmonise the guidelines internationally considering the diverse practices, standards and legislations across different geographies.
Optimizing measurements sequences for quantum state verification
Authors: Liang Weichao , Ticozzi Francesco , Vallone Giuseppe 
Published: November 2023

AbstractWe consider the problem of deciding whether a given state preparation, i.e., a source of quantum states, is accurate; namely, it produces states close to a target one within a prescribed threshold. While most of the result in the literature considers the case in which the measurement operators can be arbitrarily chosen depending on the target state, obtaining favorable (Heisenberg) scaling, we focus on the case in which the measurements can be only chosen from a given set. We show that, in this case, the order of measurements is critical for quickly assessing accuracy. We propose and compare different strategies to compute optimal or suboptimal measurement sequences either relying solely on a priori information, i.e., the target state for state preparation, or actively adapting the sequence to the previously obtained measurements. Numerical simulations show that the proposed algorithms reduce significantly the number of measurements needed for verification and indicate an advantage for the adaptive protocol especially assessing faulty preparations.
Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis
Authors: Rovira-Llopis Susana , Luna-Marco Clara , Perea-Galera Laura , Bañuls Celia , Morillas Carlos , Victor Victor M. 
Published: November 2023

AbstractDaily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TRE for at least 4 weeks. 20 studies were included in the qualitative systematic review, and 18 studies (n = 1169 subjects) were included in the meta-analysis. Overall, TRE had no significant effect on fasting glucose (Hedges’s g = -0.08; 95% CI:-0.31,0.16; p = 0.52), but it did reduce HbA1c levels (Hedges’s g = -0.27; 95% CI: -0.47, -0.06; p = 0.01). TRE significantly reduced fasting insulin (Hedges’s g = -0.40; 95% CI: -0.73,-0.08; p = 0.01) and showed a tendency to decrease HOMA-IR (Hedges’s g = -0.32; 95% CI:-0.66,0.02; p = 0.06). Interestingly, a cumulative analysis showed that the beneficial effects of TRE regarding glucose levels were less apparent as studies with later TRE windows (lTRE) were being included. Indeed, a subgroup analysis of the early TRE (eTRE) studies revealed that fasting glucose was significantly reduced by eTRE (Hedges’s g = -0.38; 95% CI:-0.62, -0.14; p < 0.01). Our meta-analysis suggests that TRE can reduce HbA1c and insulin levels, and that timing of food intake is a crucial factor in the metabolic benefit of TRE, as only eTRE is capable of reducing fasting glucose levels in subjects with overweight or obesity.PROSPERO registration number CRD42023405946.
Expert Consensus on SABA Use for Asthma Clinical Decision-Making: A Delphi Approach
Authors: Lugogo Njira , O’Connor Maeve , George Maureen , Merchant Rajan , Bensch Greg , Portnoy Jay , Oppenheimer John , Castro Mario 
Published: November 2023

Abstract
Purpose of Review
A modified Delphi process was undertaken to provide a US expert-led consensus to guide clinical action on short-acting beta2-agonist (SABA) use. This comprised an online survey (Phase 1), forum discussion and statement development (Phase 2), and statement adjudication (Phase 3).

Recent Findings
In Phase 1 (n = 100 clinicians), 12% routinely provided patients with ≥4 SABA prescriptions/year, 73% solicited SABA use frequency at every patient visit, and 21% did not consult asthma guidelines/expert reports. Phase 3 experts (n = 8) reached consensus (median Likert score, interquartile range) that use of ≥3 SABA canisters/year is associated with increased risk of exacerbation and asthma-related death (5, 4.75–5); SABA use history should be solicited at every patient visit (5, 4.75–5); usage patterns over time, not absolute thresholds, should guide response to SABA overuse (5, 4.5–5).

Summary
Future asthma guidelines should include clear recommendations regarding SABA usage, using expert-led thresholds for action.
Transcriptional Signatures of a Dynamic Epilepsy Process Reveal Potential Immune Regulation
Authors: Huang Yanruo , Wang Qihang , Liu Xiaoyin , Du Wenjie , Hao Zijian , Wang Yingwei 
Published: November 2023

AbstractEpilepsy is a progression of development and advancement over time. However, the molecular features of epilepsy were poorly studied from a dynamic developmental perspective. We intend to investigate the key mechanisms in the process of epilepsy by exploring the roles of stage-specifically expressed genes. By using time-course transcriptomic data of epileptic samples, we first analyzed the molecular features of epilepsy in different stages and divided it into progression and remission stages based on their transcriptomic features. 34 stage-specifically expressed genes were then identified by the Tau index and verified in other epileptic datasets. These genes were then enriched for immune-related biological functions. Furthermore, we found that the level of immune infiltration and mechanisms at different stages were different, which may result from different types of immune cells playing leading roles in distinct stages. Our findings indicated an essential role of immune regulation as the potential mechanism of epilepsy development.
Lowering Hippocampal miR-29a Expression Slows Cognitive Decline and Reduces Beta-Amyloid Deposition in 5×FAD Mice
Authors: Mei Zhen , Liu Jiaqi , Schroeder Jason P , Weinshenker David , Duong Duc M. , Seyfried Nicholas T. , Li Yujing , Jin Peng , Wingo Aliza P. , Wingo Thomas S. 
Published: November 2023

AbstractmicroRNA-29a (miR-29a) increases with age in humans and mice, and, in the brain, it has a role in neuronal maturation and response to inflammation. We previously found higher miR-29a levels in the human brain to be associated with faster antemortem cognitive decline, suggesting that lowering miR-29a levels could ameliorate memory impairment in the 5×FAD AD mouse model. To test this, we generated an adeno-associated virus (AAV) expressing GFP and a miR-29a “sponge” or empty vector. We found that the AAV expressing miR-29a sponge functionally reduced miR-29a levels and improved measures of memory in the Morris water maze and fear condition paradigms when delivered to the hippocampi of 5×FAD and WT mice. miR-29a sponge significantly reduced hippocampal beta-amyloid deposition in 5×FAD mice and lowered astrocyte and microglia activation in both 5×FAD and WT mice. Using transcriptomic and proteomic sequencing, we identified Plxna1 and Wdfy1 as putative effectors at the transcript and protein level in WT and 5×FAD mice, respectively. These data indicate that lower miR-29a levels mitigate cognitive decline, making miR-29a and its target genes worth further evaluation as targets to mitigate Alzheimer’s disease (AD).