bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYP4FB1 and CYP301B1 mediate the cross‐resistance of Laodelphax striatellus (Hemiptera: Delphacidae) to three pyrethroids
Authors: Yu Wenjing , Ren Qingqing , Jin Lingyao , Wu Min 
Published: December 2023

AbstractThe small brown planthopper (SBPH), Laodelphax striatellus (Fallén), is an important pest of rice that has developed resistance and even cross‐resistance to insecticides. In a previous study, we found that the resistance mechanism of a deltamethrin‐resistant strain of SBPH (JH‐del) involved the enhancement of detoxification enzyme activity and was unrelated to target resistance. The JH‐del strain exhibited cross‐resistance to fenvalerate. To explore the detoxification enzymes responsible for cross‐resistance to pyrethroids in the SBPH, quantitative real‐time PCR, transgenic Drosophila technology, the GAL4/UAS system and inhibition assays of recombinantly expressed P450s were carried out. Transgenic Drosophila strains da > CYP4FB1 and da > CYP301B1 overexpressing SBPH CYP4FB1 and CYP301B1 showed significantly increased resistance to deltamethrin, fenvalerate and etofenprox. CYP4FB1 and CYP301B1 were overexpressed by 3.41‐ and 4.99‐fold, respectively, in the JH‐del strain. Recombinant CYP4FB1 and CYP301B1 showed good O‐demethylation and O‐deethylation activities on p‐nitroanisole (PNA) and 7‐ethoxycoumarin (EC), respectively. The half‐maximal inhibitory concentrations (IC50) of deltamethrin, fenvalerate and etofenprox on recombinant CYP4FB1 and CYP301B1 were 0.15–1.35 μM, while those of chlorpyrifos and imidacloprid against recombinant CYP4FB1 and CYP301B1 were 6.99–15.91 μM. Therefore, recombinant CYP4FB1 and CYP301B1 have a strong affinity for pyrethroids and a weak binding ability to other types of insecticides. In summary, CYP4FB1 and CYP301B1 are the detoxification enzymes that mediate the cross‐resistance of the JH‐del strain to three pyrethroids. The results revealed the cross‐resistance mechanism of SBPH to pyrethroids and provided a theoretical basis for the resistance management of SBPH.
Interagency deployment of a shared low‐cost flood monitoring system to improve flood resilience across Southeast Texas: A case study
Authors: Adesina Mubarak , Brake Nicholas , Haselbach Liv , Hariri Asli Hossein 
Published: December 2023

AbstractIn 2021, eight counties in Southeast Texas formed a non‐tax authority flood control partnership to provide a forum for communication, create a regional database and improve flood modeling, early warning, and flood mitigation decisions. This partnership is able to successfully deploy and manage an early warning flood system network at relatively low‐cost by: (i) assigning the university as technical expert and general network administrator so that no additional agency workforce is required to operate and maintain the system, (ii) the flood monitoring system is a simple system and (iii) the data was able to be displayed in real‐time using an existing web‐based dashboard owned and operated by another agency within the partnership. The low‐cost sensors are lightweight and easily mountable which allowed them to be rapidly deployed within a short period of time (73 sensor sites installed within 7‐month window) over a 6000 square mile area. The data is shared with the public, and local, state, and federal agencies to monitor drainage infrastructure, and provide the community with flash flood and roadway closure alerts.
Lactic acid sting test and capsaicin test differentially induce facial erythematous reaction in subjects with sensitive skin
Authors: Li Qingwen , Xu Yujuan , Shu Hong , Li Na , Gu Hua , He Li , Tu Ying 
Published: December 2023

AbstractBackgroundSensitivity skin (SS) is a common skin disorders, which have a various of clinical manifestation. Facial erythema is common objective symptom of SS. However, the reasons for the occurrence of erythema in sensitive skin are not fully understood.AimsIn this study, we preliminarily explain the possible factors inducing erythema of sensitive skin by evaluating facial erythematous reaction to lactic acid sting test (LAST) and capsaicin test (CAT) in subjects with sensitive skin.MethodsA total of 197 subjects were divided into five groups, that is, normal controls (NC), LAST‐positive (LAST+), both LAST and CAT positive (L+C+), both LAST and CAT negative (L−C−) and CAT‐positive (CAT+). Erythema index (EI), a* value, and tissue viability imaging (TIVI) were measured before and after LAST and CAT, The ΔEI, Δa*, and ΔTIVI before and after LAST and CAT were calculated, and the correlation between the scores of CAT, EI values, a* values, and TIVI values were analyzed to clarify the causes of facial erythema.ResultsOur results showed that EI values and a* values were significantly higher in the L+C+ and CAT+ group than in NC group, TIVI values were higher in the L+C+ group than in NC group. ΔEI and Δa* values after LAST did not differ significantly among five groups. However, ΔEI values in L+C+ group were higher than that in L−C− group, while Δa* values were higher in CAT+ group than in NC. Moreover, ΔTIVI values in L+C+ group and CAT+ group were also significantly higher than that in NC group after capsaicin stimulation. CAT scores correlated positively with EI, a* and TIVI values.ConclusionOur results suggest that sensitive skin subjects with positive CAT are more likely to experience erythema reactions, and vasodilation is more pronounced after capsaicin stimulation. Reducing vascular and neural hyperreactivity could be therapeutic target in management of facial erythema in subjects with sensitive skin.
Comparative efficacy and safety of tranexamic acid for melasma by different administration methods: A systematic review and network meta‐analysis
Authors: Liang Rongzhou , Luo Haiyan , Pan Wanwan , Yang Sifen , Peng Xiaoyun , Kuang Baizeng , Huang Hongyin , Liu Chengjiang 
Published: December 2023

AbstractBackgroundTranexamic acid (TA) is a new and promising drug for the treatment of melasma.ObjectivesThis network meta‐analysis aims to compare the efficacy and safety of various ways of administration of TA on melasma.MethodsWe collected researches from PubMed, EMBASE, Cochrane Library and Web of Science. Melasma area severity index (MASI) is used to evaluate the severity of melasma. After treatment with different TA administration methods, a difference in MASI is named ΔMASI. We evaluate the curative effect by comparing the ΔMASI of different TA administration methods at a certain time point.ResultsAt the Weeks 4, 8, and 12 and the last follow‐up, the ΔMASI of oral TA combined with routine topical agents (oTA + RTA) was higher than that of intradermal TA (iTA), topical TA (tTA) as well as microneedling TA (MNsTA), with statistical significance. At the 8th week, the ΔMASI of oTA was higher than that of iTA, with statistical significance. Compared with placebo, oTA showed statistically significant differences at Week 4, while tTA, iTA, and MNsTA showed statistically significant differences starting from Week 8.ConclusionsAmong various ways of administration of TA, oTA + RTA has the best effect on melasma. In the short term, the curative effect of oTA is better than that of iTA, and the onset time of oTA is faster than that of tTA, iTA and MNsTA. In the long run, the curative effect of TA alone has nothing to do with the mode of administration.
Coping strategies and its relationship with sexual dysfunction in adults receiving haemodialysis and peritoneal dialysis: A cross‐sectional study
Authors: Ceylan Hatice , Yangöz Şefika Tuğba , Özer Zeynep 
Published: December 2023

AbstractAimTo explore relationship coping strategies and sexual dysfunction, and the predictive factors of sexual dysfunction in adults receiving haemodialysis and peritoneal dialysis.BackgroundSexual dysfunction is a common problem in adults receiving haemodialysis and peritoneal dialysis. This problem may be related to psychological and physiological conditions. However, the association between psychological conditions such as coping strategies and sexual dysfunction is not clearly understood.DesignThis study is a cross‐sectional study.MethodsThe data were collected from November 2021 to July 2022 using the General Information Form, Arizona Sexual Experiences Scale: Female and Male Versions, and the Ways of Coping Inventory. Correlation and multiple regression analyses were conducted to investigate the relationship between coping strategies and sexual dysfunction.Reporting MethodSTROBE checklist.ResultsA total of 110 adults, 67 on haemodialysis and 43 on peritoneal dialysis, who met the eligibility criteria were included in this study. The optimistic, helpless and submissive approach sub‐dimensions of coping strategies had positive correlation with sexual dysfunction in adults receiving haemodialysis. Among the sub‐dimensions of the ways of coping inventory, helpless approach was positive predictor and seeking social support was negative predictor of sexual dysfunction in adults receiving haemodialysis. The coping strategies were not predictors of sexual dysfunction for adults receiving peritoneal dialysis.ConclusionsThis study showed that helpless coping strategy increases sexual dysfunction, and seeking social support decreases sexual dysfunction in haemodialysis.Implications for the profession and/or patient careAccording to this study, social support is effective coping strategy for reducing sexual dysfunction. Education and support for effective coping strategies should be provided to dialysis patients by healthcare professionals at the start of dialysis treatment. Effective coping strategies should be integrated into routine care standards and nursing or hospital policies.Patient or Public ContributionAdults receiving haemodialysis and peritoneal dialysis were involved in this study.
Disclosing to Informed Traders
Authors: BANERJEE SNEHAL , MARINOVIC IVÁN , SMITH KEVIN 
Published: December 2023

ABSTRACTWe develop a model in which a firm's manager can voluntarily disclose to privately informed investors. In equilibrium, the manager only discloses sufficiently favorable news. If the manager is known to be informed but disclosure is costly, the probability of disclosure increases with market liquidity and the stock trades at a discount relative to expected cash flows. However, when investors are uncertain about whether the manager is informed, disclosure can decrease with market liquidity and the stock can trade at a premium relative to expected cash flows. Moreover, contrary to common intuition, public information can crowd in more voluntary disclosure.
The Virtue of Complexity in Return Prediction
Authors: KELLY BRYAN , MALAMUD SEMYON , ZHOU KANGYING 
Published: December 2023

ABSTRACTMuch of the extant literature predicts market returns with “simple” models that use only a few parameters. Contrary to conventional wisdom, we theoretically prove that simple models severely understate return predictability compared to “complex” models in which the number of parameters exceeds the number of observations. We empirically document the virtue of complexity in U.S. equity market return prediction. Our findings establish the rationale for modeling expected returns through machine learning.
Clinical outcomes of fetuses with cardiac rhabdomyoma: A case series from a tertiary center
Authors: Okutucu Gulcan , Tanacan Atakan , Sahin Dilek 
Published: December 2023

AbstractAimsThe study aims to evaluate the genetic and clinical outcomes of fetal cardiac rhabdomyoma in our tertiary center.MethodsData of cases with cardiac rhabdomyoma detected by fetal echocardiography during antenatal follow‐up were analyzed retrospectively.ResultsNine cases were included in the study. The incidence of cardiac rhabdomyoma was 0.003%. The median fetal diagnosis time was 26th weeks, the most common location was the LV. There was no hemodynamic disorder requiring cardiovascular intervention in any of the cases. Of the eight genetically tested cases, four were tuberous sclerosis complex (TSC) gene‐negative, one hereditary TSC2, one de novo TSC1, and two de novo TSC2 gene mutants. Postnatal first‐year survival rate of the cases was 88.8%.ConclusionsCardiac rhabdomyoma is a rare fetal and pediatric pathology that generally is a remarkable finding in the clinical process of TSC. Therefore, cases should be evaluated multisystemically and genetic counseling should be given to the family.
How to speak to the masses, part II: Hồ Chí Minh as a moral and linguistic exemplar and the dynamics of register formation in 20th century Vietnam
Authors: Sidnell Jack 
Published: December 2023

AbstractHồ Chí Minh's extended essay Fixing the Way We Work, written in 1947 after he and other high‐ranking members of the recently formed DRV (Democratic Republic of Vietnam; Việt Nam Dân chủ Cộng hòa), had been forced to retreat from Hanoi to the uplands of Thái Nguyên province, elaborates on organizational and practical problems within the party and obstacles to mass mobilization. The final chapter describes a way of speaking HCM refers to as ba hoa and which he sees as a “speech sickness” afflicting many low and middle ranking cadres who are in direct contact with the masses. In the first part of this essay, I argued that the largely proscriptive and negatively formulated instructions articulated in this context cohere by virtue of a common focus on problems of action. Specifically, ba hoa names a stereotyped speech register in which the connection between speaking and doing comes undone. In what follows, the second part of the essay, I describe the other, positively formulated half of the larger project of register formation: the elevation of HCM's own mode of expression (phong cách diễn đạt) to the status of an exemplary model that all Vietnamese people are expected to emulate. This involved extensive metasemiotic elaboration and (re)framing which was accomplished, in large part, through the writings of contemporaries and later interpreters. A consideration of this literature along with an analysis of the continued spectral presence of HCM in contemporary Vietnam allows for a specification of the semiotics of exemplarity.
Every action has a reaction: A model of coworker reactions to sexual minority employees' identity disclosure
Authors: Dhanani Lindsay Y. , Totton Rebecca , Hall Taylor K. 
Published: December 2023

AbstractThe current study examines the predictors and consequences of the ways coworkers react following sexual identity disclosure. We propose that employees may experience different reactions following disclosure depending on their social and sexual identities and that such reactions will impact their job attitudes, well‐being, and subsequent identity concealment. Data were collected from 308 lesbian, gay, bisexual, and pansexual employees using a two‐wave field survey design. Results for the predictors of coworker reactions indicate that employees who identified as Black, transgender/genderqueer, or bisexual/pansexual reported they experienced more unsupportive reactions from their coworkers following the disclosure of their sexual identity as compared to White, cisgender, and gay/lesbian employees. Supplemental analyses further indicate that Black bisexual/pansexual employees experienced the least positive reactions from coworkers as compared to the other referent groups. Results examining the outcomes of coworker reactions demonstrate that positive disclosure reactions are associated with decreased job satisfaction and increased turnover intentions, emotional exhaustion, and subsequent identity concealment, whereas negative disclosure reactions are associated with increased depressive symptoms and emotional exhaustion. Findings demonstrate a need to expand on conceptual and empirical work on identity disclosure to consider coworker reactions and underscore that the disclosure experiences of sexual minority employees are not uniform.
Among risks, protection, and lessons learned: Perspectives of Brazilian rural families about work in adolescence
Authors: Santana Ramiro Rodrigues Coni , Ristum Marilena 
Published: December 2023

AbstractAdolescents working in the Brazilian rural contexts were investigated through participant observation and interviews, aiming at understanding the role played by work in the nurturing of adolescent in these contexts. The qualitative and longitudinal survey involved six participants who were members of two different families, as follows: four female adolescents, one adult woman, and one adult man. It was found that adolescents and their families understood work as a context for nurturing moral values, learning skills, and meeting needs. Observation, however, found that work also involved exposure to risks. The study reviews the role of work in adolescence as a cultural component in some rural contexts and how this should be taken into account to avoid an ethnocentric and universalistic interpretation that divides adolescence between “normal” and “abnormal.”
Clinical relevance of serum ionized magnesium concentration in dogs with myxomatous mitral valve disease
Authors: Kim Ock‐Kyu , Kim Keon , Park Sinwook , Yang Hayoung , Kim Hyunwoo , Ro Woong‐Bin , Lee Chang‐Min 
Published: December 2023

AbstractBackgroundHypomagnesemia is associated with a poor prognosis in humans with congestive heart failure (CHF), but studies in veterinary medicine are limited.HypothesisSerum ionized magnesium concentration [iMg2+] would decrease as CHF progresses compared with the initial diagnostic levels and that lower [iMg2+] would be negatively associated with prognosis in dogs with CHF.AnimalsA total of 181 client‐owned dogs with myxomatous mitral valve disease (MMVD) were included. They were classified into the preclinical stage (NO‐CHF, n = 108), stage C (n = 42), and stage D (n = 31) based on the American College of Veterinary Internal Medicine MMVD classification.MethodsThis is a retrospective study from 2 referral centers. The [iMg2+] was compared among the NO‐CHF, stage C, and stage D groups. Kaplan‐Meier curves and the log‐rank test were used to compare the incidence of death between groups. Multivariable Cox regression analysis was used to estimate the association of hypomagnesemia with the death.ResultsIn the stage D group, the [iMg2+] was lower than that in the NO‐CHF (P < .0001) and stage C groups (P < .003). In the Kaplan‐Meier survival analysis, the 1‐year cumulative survival rate in hypomagnesemic dogs was 53% compared with 91.5% in normomagnesemic dogs (log‐rank test, P < .0001). In the multivariable Cox analysis, lower concentration of [K+] and [iMg2+], along with higher Evel, were associated with negative prognoses. Specifically, hypomagnesemia was associated with an approximately 4‐fold increased risk of death (hazard ratio = 4.015; 95% confidence interval, 1.537‐10.488; P = .005).Conclusions and Clinical ImportanceAssessing the [iMg2+] might serve as a potential marker for estimating the severity and prognosis indirectly in dogs with MMVD. Combining [iMg2+] measurement with other diagnostic methods, such as echocardiography, could improve the prognostic evaluation of MMVD in dogs.
Health first, convenience second: Caregiver perspectives of commercially produced complementary foods in five Southeast Asian capital cities
Authors: Walls Helen , Pries Alissa , Chotivichien Saipin , Huynh Phuong , Fahmida Umi , Blankenship Jessica 
Published: December 2023

AbstractCaregivers in low‐ and middle‐income countries increasingly feed commercially produced complementary foods (CPCF) to older infants and young children—shaped by factors including industry promotion. The dynamics of CPCF consumption and caregiver knowledge, attitudes and behaviours regarding complementary feeding practices are poorly understood in these settings. We examined how caregiver knowledge/attitudes/behaviours about CPCF shape the feeding of older infants and young children in the capital cities of five countries in Southeast Asia (Bangkok, Hanoi, Jakarta, Kuala Lumpur, Manila). An online, web‐based, cross‐sectional panel survey was conducted among mothers of a child aged 6−23 months. One hundred participants were included in each of the five capital cities. Questionnaires were undertaken in the official language of each city. Data were analysed in Stata (version 17.0), using χ2 tests to examine difference between variables of interest. All mothers purchased CPCF for their youngest child aged 6−23 months at the time of survey. CPCF were commonly fed to children at least once per day, and in many of the five cities at most or every feeding. While factors such as convenience and affordability influenced CPCF purchase, mothers primarily purchased CPCF for nutritional reasons. The most common source of feeding information was health care professionals, followed by social media. CPCF are ubiquitous in the diets of older infants and young children of educated middle–upper socioeconomic status mothers in capital cities of Southeast Asia, with perceived healthiness a key driver in selecting CPCF. A strong governmental regulatory response to industry marketing/promotion will be critical to addressing CPCF appropriateness, including health and nutritional claim use.
Ornithomya biloba, Pseudolynchia garzettae and Pseudolynchia canariensis (Diptera: Hippoboscidae): three new United Kingdom colonists and potential disease vectors
Authors: Wawman Denise C. 
Published: December 2023

AbstractIn the northern hemisphere, many species' ranges are shifting northwards with climate change. Here I present evidence, from the first large‐scale citizen science study of the Hippoboscidae in the United Kingdom, for the colonisation of the United Kingdom by three species of Diptera in the family Hippoboscidae, which are obligate ectoparasites of birds. The Swallow Louse Fly, Ornithomya biloba; the Nightjar Louse Fly, Pseudolynchia garzettae and the Pigeon Louse Fly, Pseudolynchia canariensis were previously considered to be vagrants from more southerly latitudes but the presence of a pair taken possibly in the act of copulation, gravid females and the increase in numbers of the various species provides good evidence of local breeding activity. I discuss the potential for further northwards range shift and whether the presence of three new species of parasite may have implications for the spread of avian disease within the region. I also include a concise key to the genus Pseudolynchia and images of P. canariensis, P. garzettae and O. biloba to aid further identification of these species in the region.
Mediator subunit MED8 interacts with heat shock transcription factor HSF3 to promote fucoxanthin synthesis in the diatom Phaeodactylum tricornutum
Authors: Zhao Hejing , Liu Yan , Zhu Zhengjiang , Feng Qingkai , Ye Yuemei , Zhang Jinrong , Han Jichang , Zhou Chengxu , Xu Jilin , Yan Xiaojun , Li Xiaohui 
Published: December 2023

Summary
Fucoxanthin, a natural carotenoid that has substantial pharmaceutical value due to its anticancer, antioxidant, antiobesity, and antidiabetic properties, is biosynthesized from glyceraldehyde‐3‐phosphate (G3P) via a series of enzymatic reactions. However, our understanding of the transcriptional mechanisms involved in fucoxanthin biosynthesis remains limited.
Using reverse genetics, the med8 mutant was identified based on its phenotype of reduced fucoxanthin content, and the biological functions of MED8 in fucoxanthin synthesis were characterized using approaches such as gene expression, protein subcellular localization, protein–protein interaction and chromatin immunoprecipitation assay.
Gene‐editing mutants of MED8 exhibited decreased fucoxanthin content as well as reduced expression levels of six key genes involved in fucoxanthin synthesis, namely DXS, PSY1, ZDS‐like, CRTISO5, ZEP1, and ZEP3, when compared to the wild‐type (WT) strain. Furthermore, we showed that MED8 interacts with HSF3, and genetic analysis revealed their shared involvement in the genetic pathway governing fucoxanthin synthesis. Additionally, HSF3 was required for MED8 association with the promoters of the six fucoxanthin synthesis genes.
In conclusion, MED8 and HSF3 are involved in fucoxanthin synthesis by modulating the expression of the fucoxanthin synthesis genes. Our results increase the understanding of the molecular regulation mechanisms underlying fucoxanthin synthesis in the diatom P. tricornutum.