bluuebunny/crossref_metadata_2025_split huggingface dataset:
РІДКІСНИЙ ЧЕСЬКИЙ ДЕНАРІЙ ПОЧАТКУ ХІІ СТОЛІТТЯ, ЗНАЙДЕНИЙ НА КИЇВЩИНІ
Authors: Kuleshov  
Published: December 2023

Ця розвідка продовжує спроби автора висвітлити питання обігу у Стародавній Руси денаріїв різних європейських країн. Мета статті – атрибуція, знайденого на Київщині європейського денарія, формулювання припущень щодо семантики його зображень та написів на ньому, а також гіпотези щодо його обігу. Методологія дослідження. Застосовано методи історизму, узагальнення, об’єктивності, історико-типологічний, порівняльного аналізу. Наукова новизна. Знайдений денарій, який первісно було визначено як угорський, атрибутовано як чеський князя Боривоя ІІ, причому наголошено на його унікальності в частині зображення на реверсі у вигляді трьох хрестів. Рідкісність цього артефакту може пояснюватись тим, що цей вид був останнім у карбуванні князя і він не отримав достатнього поширення в Чехії та Моравії, де, ймовірно. його було карбовано в останній рік третього періоду правління Боривоя. Втеча Боривоя зі значною частиною цих денаріїв до Угорщини надалі могла зумовити копіювання його реверсу угорськими монетаріями. Висновки. Автор сподівається у віднайденні такого денарія в каталогах чи письмових фіксаціях археологічних досліджень, що дасть можливість ймовірної його атрибуції та підтвердження або спростування його гіпотез. А нині ця монета залишається унікальною. Взагалі, підсумовуючи, варто констатувати, що знахідка чеського денарія підтверджує нашу гіпотезу щодо наявності європейських монет на початку ХІІ століття у грошовому обігові в Київській Руси.
Effect of Lambda-cyhalothrin on the Gill Phospholipid (PL) Subclass of Oreochromis niloticus
Authors: YOLCU Murat , SATAR Elif İpek 
Published: December 2023

Fatty acids have a crucial role in providing energy and performing essential functions in living organisms. Moreover, these substances exhibit the most significant alterations in their structure based on ecotoxicological parameters when viewed from a biochemical perspective. These bioactive chemicals are present in the cellular architecture. The study of these fatty acids, crucial for maintaining the integrity and permeability of cell membranes, holds great significance for all living organisms. Consequently, doing fatty acid analysis specifically at the phospholipid level holds significant importance.
The impact of lambda cyhalothrin on the fatty acid content of several phospholipid subclasses (phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidylserine (PS) in the gill tissue of O. niloticus (Perciformes: Cichlidae) was assessed using gas chromatography. The alterations in the fatty acid composition was analyzed 21 days after exposure.
Following the complete extraction of lipids from gill tissue, the tissue was subsequently separated into different subclasses of phospholipids using thin layer chromatography. The samples were subjected to methylation and then evaluated using Gas Chromatography to determine the percentage of the fatty acid. After doing the analysis, a grand total of 16 fatty acids were identified. The research revealed that the primary fatty acids were 16:0 and 18:0 of saturated fatty acids, monounsaturated 18:1n-9, and polyunsaturated 18:2n-6, 20:4n-6, and 22:6n-6. Upon analyzing the distribution of fatty acids, it was observed that PC, PE, and PI included 16:0, PE contained 18:1, PE and PS contained C18:2n-6 and 20:4n-6, and significant alterations in C22:6n-3 were detected in PE. Our investigation revealed that the n-3/n-6 ratio of fish in the PE subclass was the lowest when compared to PC, PI, and PS.
Helicobacter pylori y enfermedades alérgicas en niños: un estudio de casos y controles
Authors: Naveda Omar , Pérez Henry , Meléndez Daniela , Mendoza Victoria 
Published: December 2023

Introducción: En las dos últimas décadas, se ha explorado el rol de la infección por Helicobacter pylori en la génesis de las enfermedades alérgicas, obteniéndose datos que apoyan la idea de que podría jugar un papel importante en el desarrollo de la alergia.
Objetivo: Identificar la asociación entre Helicobacter pylori y enfermedades alérgicas.
Materiales y métodos: Estudio de casos y controles prospectivo realizado en la Clínica “Santa Cruz” (Barquisimeto, Estado Lara, Venezuela), entre junio 2022 y junio 2023, donde se compararon 65 niños con enfermedades alérgicas con 130 controles sanos, con edades entre 2 y 15 años, que acudieron a consulta ambulatoria de rutina. Fueron comparadas variables demográficas, parto por cesárea, antecedentes familiares de alergias, tiempo de lactancia materna, exposición al humo de tabaco, mascotas, obesidad, porcentaje de eosinófilos y test de Helicobacter pylori positivo en heces con la presencia de enfermedades alérgicas como variable dependiente. Se utilizó: análisis bivariable y regresión logística binaria.
Resultados: Los factores asociados significativamente a enfermedades alérgicas fueron: antecedentes familiares de alergia, tiempo de lactancia materna menor a 12 meses, y test de Helicobacter pylori positivo en heces. Fueron identificados como predictores independientes asociados a enfermedades alérgicas: antecedentes familiares de alergia (RO=2,345; IC95%: 1,245 – 4,416; p = 0,008) y test de Helicobacter pylori positivo en heces (RO=2,072; IC95%: 1,090 – 3,939; p = 0,026).
Conclusión: La presencia de antecedentes familiares de alergia y test de Helicobacter pylori positivo en heces fueron identificados como variables independientes asociadas a enfermedades alérgicas.
Biosorption of Ciprofloxacin (CIP) using the Waste of Extraction Process of Microalgae: The Equilibrium Isotherm and Kinetic Study
Authors: Al-Mashhadani Enass S. M. , Al-Mashhadani Mahmood K. H. , Al-Maari Mohammed Abobakr 
Published: December 2023

Scientists are investigating the efficacy of different biosorbents for promoting economic and environmental viability in purifying contaminants. Among the primary by-products of biodiesel production is waste microalgae biomass, which has the potential to be used as a cheap biosorbent for the treatment of pollution. In the present study, the biomass left over after extracting the chlorella vulgaris was used to test the potential biosorption of CIP from simulated aqueous solutions. Bisorbent's ability was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). Analysis with a Fourier Transform Infrared Spectrometer revealed that CIP biosorption occurred mainly at biomass sites containing carboxyl and amino groups. The equilibrium isotherm data and biosorption kinetics were addressed in the present study. The biosorption data match the Langmuir isotherm model, and the maximal biosorption capacity was determined to be 7.56 mg/g. While The pseudo-second-order model accurately described the biosorption kinetic data. Biosorbent regeneration was also studied using two different sodium hydroxide concentrations, the results showing that after desorption, the biosorption capacity decreased from 5.2 to 3.74 and 1.77 (mg/g) using 0.1NaOH and 0.5NaOH, respectively.
Interpretation of Mud Losses in Carbonates Based on Cuttings Description, Well-Logging, Seismic and Coherency Data
Authors: Bashara Zainab R. , A. Hadi Farqad , Kasing Martin 
Published: December 2023

Hartha Formation is an overburdened horizon in the X-oilfield which generates a lot of Non-Productive Time (NPT) associated with drilling mud losses. This study has been conducted to investigate the loss events in this formation as well as to provide geological interpretations based on datasets from nine wells in this field of interest. The interpretation was based on different analyses including wireline logs, cuttings descriptions, image logs, and analog data. Seismic and coherency data were also used to formulate the geological interpretations and calibrate that with the loss events of the Hartha Fm.
The results revealed that the upper part of the Hartha Fm. was identified as an interval capable of creating potential mud losses, resulting in high NPT. This is due to its diagenetic features such as succrosic dolomites and vuggy zones that could act as thief zones. Seismic potential was used for the prediction of the geological related non-productive drilling time in the Hartha interval. The seismic data quality in this interval was good, with geological observations already made. Detailed interpretation and analysis of the Hartha interval were performed and integrated with the existing seismic interpretation, rock properties, and NPT database to calibrate wells with the loss events to the seismic observations.
Enhancing brain entry and therapeutic activity of chimeric antigen receptor T cells with intra-arterial NEO100 in a mouse model of CNS lymphoma
Authors: Wang Weijun , He Haiping , Zheng Long , Zeng Shan , Cho Hee-Yeon , Kouhi Aida , Khawli Leslie A. , Chen Ligang , Stathopoulos Apostolos , Schönthal Axel H. , Epstein Alan L. , Chen Thomas C. 
Published: December 2023

OBJECTIVE
Malignancies of the CNS are difficult to treat because the blood-brain barrier (BBB) prevents most therapeutics from reaching the intracranial lesions at sufficiently high concentrations. This also applies to chimeric antigen receptor (CAR) T cells, for which systemic delivery is inferior to direct intratumoral or intraventricular injection of the cells. The authors previously reported on a novel approach to safely and reversibly open the BBB of mice by applying intra-arterial (IA) injections of NEO100, a pharmaceutical-grade version of the natural monoterpene perillyl alcohol. The authors hypothesized that this method would enable enhanced brain entry and therapeutic activity of intravenously delivered CAR T cells, which the authors tested in a mouse model of CNS lymphoma.

METHODS
Human Raji lymphoma cells were implanted into the brains of immune-deficient mice. After tumor uptake was confirmed with bioluminescent imaging, 0.3% NEO100 was injected intra-arterially, which was followed by intravenous (IV) delivery of CD19-targeted CAR T cells. After this single intervention, tumor growth was monitored with imaging, long-term survival of mice was recorded, and select mice were euthanized to analyze the distribution of CAR T cells in brain tissue.

RESULTS
Intravenously injected CAR T cells could be readily detected in brain tumor areas after IA injection of NEO100 but not after IA injection of the vehicle (without NEO100). Although all untreated control animals died within 3 weeks, all mice that received IA NEO100 followed by IV CAR T cells survived and thrived for 200 days, when the experiment was terminated. Of the mice that received IV CAR T cells without prior IA NEO100, 3 died within 3 weeks and 2 survived long-term.

CONCLUSIONS
BBB opening by IA NEO100 facilitates brain entry of intravenously delivered CD19 CAR T cells. The long-term survival of all mice with CNS lymphoma, along with the disappearance of the tumor as determined with imaging, suggests that this one-time therapeutic intervention was curative. BBB opening by IA NEO100 may offer a novel option to increase brain access by CAR T cells.
Evaluating mortality and 6-month functional outcomes of patients with dural venous sinus thrombosis in traumatic brain injury
Authors: Johnson Mark D. , Ventre Giancarlo J. , Kaye Joel , Patel Hemchandra B. , Naveed Asad , Prestigiacomo Charles J. , Ngwenya Laura B. 
Published: December 2023

OBJECTIVE
Patients with dural venous sinus thrombosis (DVST) in select populations following traumatic brain injury (TBI), including those with blunt mechanism or depressed skull fractures, have been shown to have an increased risk of mortality. The purpose of this study was to assess these findings in a mixed population of head trauma patients.

METHODS
The authors performed a case-control study using propensity score matching by reviewing 17 years (2004–2021) of data from their institutional trauma registry. Patients with imaging-confirmed DVST were matched to a control group of TBI patients without identified DVST based on age, sex, postresuscitation Glasgow Coma Scale (GCS) score, and Injury Severity Score. All age groups and injury mechanisms were included with a head Abbreviated Injury Scale score ≥ 3. Data on demographics, injury and radiographic characteristics, and patient outcomes were collected. Multivariable logistic regression was performed to identify predictors of inpatient mortality. An additional subgroup analysis of patients with concurrent DVST and blunt cerebrovascular injury (BCVI) was planned a priori.

RESULTS
The authors identified 9875 patients who presented to their institution over the study period with TBIs, with a 1.64% incidence of DVST. Concurrent BCVI was diagnosed in 23.5% of patients with a DVST. Following matching, the presence of DVST itself was not significantly associated with inpatient mortality (OR 0.68, 95% CI 0.24–1.88). On regression analysis, penetrating injuries (8.19, 95% CI 1.21–80.0) and lower postresuscitation GCS scores (0.69, 95% CI 0.53–0.84) were independently associated with inpatient mortality for patients with traumatic DVST. Significantly worse functional outcomes were observed in those with DVST at 3 months, with no significant difference at 6 months.

CONCLUSIONS
The authors observed a prevalence of traumatic DVST of 1.64% in a mixed population of head-injured patients, with 23.5% of patients with DVST having concurrent BCVI. Traumatic DVST alone was not associated with a significantly increased risk of inpatient mortality.
Surgery and stereotactic radiosurgery for spinal leiomyosarcoma: a single-institution retrospective series and systematic review
Authors: Zamarud Aroosa , Marianayagam Neelan J. , Sekar Vashisht , Testa Stefano , Park David J. , Yener Ulas , McCleary Tamra-Lee , Yoo Kelly H. , Emrich Sara , Tayag Armine , Ustrzynski Louisa , Pollom Erqi , Soltys Scott , Wang Lei , Charville Greg , Ganjoo Kristen , Chang Steven D. , Meola Antonio 
Published: December 2023

OBJECTIVE
Leiomyosarcoma (LMS) is a rare, aggressive soft-tissue sarcoma that seldom spreads to the bone. The spine can be either the site of LMS osseous metastases or the primary tumor site. The optimal treatment option for spinal LMS is still unclear. The authors present a cohort of patients with spinal LMS treated with either upfront surgery or upfront CyberKnife stereotactic radiosurgery (SRS).

METHODS
The authors retrospectively studied the clinical and radiological outcomes of 17 patients with spinal LMS treated at their institution between 2004 and 2020. Either surgery or SRS was used as the upfront treatment. The clinical and radiological outcomes were assessed. A systematic review of the literature was also conducted.

RESULTS
Of the 17 patients (20 spinal lesions), 12 (70.6%) were female. The median patient age was 61 years (range 41–80 years). Ten patients had upfront surgery for their spinal lesions, and 7 had upfront CyberKnife radiosurgery. The median follow-up was 11 months (range 0.3–130 months). The median overall survival (OS) for the entire cohort was 13 months (range 0.3–97 months). In subgroup analysis, the median OS was lower for the surgical group (13 months, range 0.3–50 months), while the median OS for the SRS group was 15 months (range 5–97 months) (p = 0.5). Forty percent (n = 4) of those treated with surgery presented with local recurrence at a median of 6.7 months (range 0.3–36 months), while only 14% (n = 1) of those treated with CyberKnife radiosurgery had local recurrence after 5 months. Local tumor control (LTC) rates at the 6-, 12-, and 18-month follow-ups were 72%, 58%, and 43%, respectively, for the SRS group and 40%, 30%, and 20%, respectively, for the surgery group (p < 0.05). The literature review included 35 papers with 70 patients harboring spinal LMS; only 2 patients were treated with SRS. The literature review confirms the clinical and radiological outcomes of the surgical group, while data on SRS are anecdotal.

CONCLUSIONS
The authors present the largest series in the literature of spinal LMS and the first on SRS for spinal LMS. This study shows that LTC is statistically significantly better in patients receiving upfront SRS instead of surgery. The OS does not appear different between the two groups.
Sex differences in the accuracy of vertebral bone quality score assessing bone density in patients undergoing lumbar spinal fusion
Authors: Wang *Yunsheng , Wang Feng , Tong Tong , Miao Dechao , Li Wenshuai , Zhu Houze , Zheng Xiao , Wang Linfeng 
Published: December 2023

OBJECTIVE
Low bone mineral density (BMD) significantly increases the risk of complications in patients undergoing spinal fusion. Existing evidence indicates that traditional dual-energy x-ray absorptiometry (DEXA) and quantitative CT (QCT) screening are underutilized in spine surgery. The MRI-based vertebral bone quality (VBQ) score provides a tool for primary screening of bone density. The validity of this score as a predictor across sexes has not been investigated. This study aimed to explore the effect of sex on the diagnostic efficacy of the VBQ in predicting osteopenia/osteoporosis and whether a sex-specific threshold exists.

METHODS
In this retrospective cohort study, patients who underwent lumbar fusion at a tertiary care center were reviewed. VBQ was obtained by noncontrast T1-weighted MRI. Patients were stratified according to sex and bone density. Data were analyzed between the groups. Pearson correlation analysis and linear regression were used to analyze the correlation between the VBQ and DEXA T values. Receiver operating characteristic (ROC) curve analysis, including area under the curve (AUC) calculation, was used to evaluate the predictive performance of VBQ for low BMD in both sexes.

RESULTS
A total of 271 patients (92 male, 179 female patients) were analyzed. The correlation coefficient between VBQ and the lowest T value was −0.40 for male and −0.554 for female patients. In comparing the bone density subgroups, among male patients a significant difference in the VBQ scores was observed only between the normal and osteoporosis subgroups (p = 0.012). VBQ demonstrated statistically significant differences among female patients across all three subgroups (p < 0.001). The ROC analysis revealed that the predictive performance of VBQ in detecting low BMD was more consistent with the gold-standard DEXA results in female than in male patients (AUC 0.647 vs AUC 0.823, p = 0.02). The optimal thresholds were similar in both sexes.

CONCLUSIONS
Compared with male patients, VBQ has better discrimination between female patients with low BMD and those with normal bone density. Although the correlation between VBQ and bone density is weaker in male than in female patients, the optimal thresholds are similar in both sexes.
L’entre-jeu agôn-aléa et la place du hasard dans la construction du tragique racinien
Authors: C. Tushar Iyengar Chandniée 
Published: December 2023

Dans l’épistémologie sociale de Roger Caillois, agôn et aléa sont les premiers deux principes du jeu qui se déploient entre la polarité arbitraire des tendances ludiques de paidia et de ludus. La vision traditionnelle sur les tragédies vivement soutenue par les auteurs aristotéliciens est que, dans son univers tragique particulier, l’enjeu est déterminé par une fatalité implacable dirigée du probable et du nécessaire. Cependant, dans la plupart des pièces de Racine, le cours des évènements semble tourner autour de la fortune qui finit par créer une sorte de champ médian de l’action tragique entre agôn et aléa. L’article soutient que le hasard occupe bien une place dans le théâtre de Racine, dont l’intrigue tragique doit être explorée dans une perspective stochastique. Il se sert de la notion d’« entre-jeu » empruntée aux jeux de balles signifiant le médian du terrain, position qui maximise le potentiel du hasard dans ces jeux.
Le jeu du « je » : l’écriture poétique dans L’âge d’homme de Michel Leiris
Authors: Zhao Wenjing 
Published: December 2023

Dans cet article, nous proposons d’examiner, à partir d’une série d’exemples concrets, les traits poétiques de L’âge d’homme de Michel Leiris, en s’interrogeant sur le fonctionnement de la mise en scène du « je » dans son expérimentation autobiographique. En rejetant le modèle classique de l’autobiographie, l’auteur place l’histoire de sa personnalité dans un cadre constitué d’images récurrentes où s’entremêlent des jeux sur le lexique, des liaisons analogiques et des associations apparemment arbitraires. Dans l’intention de se liquider, il repousse les limites du langage conventionnel et exploite une dimension lyrique au sein de son ouvrage narratif, en effectuant, dans le même processus, la constitution de sa genèse.
PENGARUH POLA ASUH OTORITER TERHADAP PERILAKU AGRESIF ANAK USIA DINI
Authors: Akmalia Findia Akmalia 
Published: December 2023

Pengaruh dari pola asuh orang tua bisa Sangat berdampak pada pertumbuhan dan perkembangan anak. Orang tua menerapkan pola pengasuhan otoriter Konsisten dalam penerapannya terhadap anak dari waktu ke waktu. Maksud atau tujuan yang ingin dicapai dari pelaksanaan penelitian ini guna memperoleh pemahaman atau informasi perilaku agresif anak melalui peran orang tua menggunakan pola asuh otoriter. Jenis penelitian yang dilakukan menggunakan metode studi kasus. Pengelolaan data diperoleh dari wawancara, pengamatan, dan analisis dokumen. Penelitian ini dilakukan pada TK Dharma Wanita 03 Sulakdoro-Lojejer, yang terletak di Kecamatan Wuluhan, Kabupaten Jember, penelitian ini menggambarkan serta mengevaluasi tentang pola asuh otoriter orang tua kepada anak dengan kecenderungan memberikan perilaku agresif, serta menganalisis peran orang tua melalui pola asuh otoriter untuk mengetahui perilaku anak yang cenderung agresif, hasil analisis yang didapatkan dari data diinterpretasikan yaitu: (1) terdapat empat jenis tindakan agresif pada anak, termasuk agresi fisik, agresi lisan, agresi tidak langsung dan agresi meledak; (2) munculnya perilaku agresif pada anak berdasarkan anggota keluarga di identifikasi yang berperilaku agresif selalu menggunakan kekerasan dan dipengaruhi oleh lingkungan sekitar yang tidak mendukung; (3) guru harus memiliki strategi agar perilaku agresif anak bisa diatasi dengan dengan menerapkan contoh, kebiasaan, hukuman, dan imbalan, guru juga bisa mengolah emosi anak dengan menenangkan dan menanyakan perasaan yang dirasakan oleh anak-anak; (4) pada penelitian menunjukkan hasil tidak adanya kerja sama hubungan spesifik yang terbentuk antara sekolah dan orang tua dalam mengatasi permasalahan perilaku agresif pada anak.
PENGARUH FINGER PAINTING TERHADAP PERKEMBANGAN MOTORIK HALUS ANAK USIA 4-5 TAHUN TK DHARMA WANITA TEGAL GEDE JEMBER
Authors: Amudariya Elfira 
Published: December 2023

Abstrak:
Permasalahan yang ditemukan yaitu anak masih kesulitan memegang pensil saat belajar terutama pada kelompok A (usia 4-5 tahun) di TK Dharma Wanita Tegal Gede Jember dan kurangnya stimulasi yang dilakukan oleh guru dalam mengembangkan motorik halus. Pada kelompok A yang mengikuti kegiatan ini berjumlah 15 siswa. Tujuan penelitian ini untuk mengetahui pengaruh finger painting terhadap perkembangan motorik halus anak di TK Dharma Wanita Tegal Gede Jember. Metode yang digunakan merupakan deskriptif kuantitatif yang bertujuan untuk mendeskripsikan proses pembelajaran finger painting (Seni Rupa) terhadap peningkatan motorik halus anak. Teknik pengumpulan data menggunakan teknik triangulasi yaitu observasi, wawancara dan dokumentasi. Berdasarkan hasil eksperimen, penerapan kegiatan finger painting dapat meningkatkan motorik halus anak melalui latihan jari mereka saat melukis. Hasil penelitian yang dihasilkan, bahwa melalui permainan finger painting dalam pembelajaran dikelas memiliki keefektifan tinggi pada kemampuan motorik halus anak. Hal ini dapat dilihat dari hasil uji keefektifan relatif menghasilkan nilai 65%. Selain itu melalui permainan finger panting anak dapat menggunakan imajinasinya sehingga anak dapat mengembangkan kemampuan imajinatif dan kreatifitasnya.