bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a codesigned text message-based digital oral health education resource (TOOTH)
Authors: King Shalinie , Church Lauren Adriel , O’Hagan Edel , Candelaria Dion , Pawar Aboli , Cooper Ashley , Chen Rebecca , Gibson Alice 
Published: January 2025

Objective Digital health technologies offer a more equitable way of providing access to health education. This study engaged consumers and clinicians from two Australian regions with a high burden of oral disease to develop a digital oral health resource called “TOOTH” tailored for adults. Methods A total of three focus groups (one clinician and two consumers) were conducted to identify themes that were used to draft text message content. The study team reviewed, refined, and mapped these messages to behaviour change techniques and developed videos to support key concepts. Results Eight multidisciplinary clinicians (dentist, oral health therapist, dietician, cardiac nurse, and dental nurse), 75% female with a mean age of 48 ± 10 years, and seven consumers from a metropolitan and a regional area in New South Wales, 43% female with a mean age 62 ± 11.6 years participated in the focus groups. Key themes identified by clinicians included (1) limited support from medical and allied health teams for integrating oral health care into the healthcare system, (2) government-supported measures enable prevention, and (3) poor oral health of Australians. Consumers highlighted (1) barriers to accessing oral health care, (2) negative attitudes towards oral health, and (3) limited oral health-related knowledge. The final resource developed includes 81 text messages sequenced to ensure a gradual increase in knowledge and skill and five supporting videos. Conclusions The TOOTH resource has the potential to improve awareness and knowledge regarding oral disease prevention, enabling more equitable access to oral health education and better self-management of oral health.
Psychometric properties of a physiotherapy care satisfaction scale using telerehabilitation in caregivers of pediatric patients during the COVID-19 pandemic
Authors: Gonzalez Ccosi Jessica Liz , Ricra Deysi Pedraza , Basauri-Delgado Miguel , Saintila Jacksaint 
Published: January 2025

Background Evidence on the psychometric properties of satisfaction scales in telerehabilitation is limited, especially in specific populations such as caregivers of children. Objective To determine the psychometric properties of a physiotherapy care satisfaction scale using telerehabilitation in caregivers of pediatric patients during the COVID-19 pandemic. Methods A total of 155 caregivers were evaluated between June and December 2020. Approximately 91% (141) were women. Evidence of content validity for the scale was obtained through evaluation by three expert judges, who confirmed the adaptation of the University of Washington Telemedicine Patient Satisfaction Survey, in which the word “telemedicine” was replaced with “telerehabilitation” and “physician” with “physical therapist.” Results For the confirmatory factor analysis, two models were tested. The first one-factor model with nine items did not fit satisfactorily based on the goodness-of-fit indices ( χ2/ df = 13.96, comparative fit index [CFI] = 0.963, non-normed fit index [NNFI] = 0.951, root mean square error of approximation [RMSEA] = 0.290 [0.265, 0.316], and standardized root mean square residual [SRMR] = 0.178). In contrast, the second one-factor model, which involved respecification of Items 6 and 7, was considered acceptable ( χ2/ df = 1.60, CFI = 0.998, NNFI = 0.998, RMSEA = 0.062 [0.021, 0.096], and SRMR = 0.057). Reliability was acceptable, with a value of 0.888. Additionally, network analysis confirmed the direct relationship between the items, with Item 7 showing the greatest strength centrality. Conclusion The instrument demonstrated sufficient evidence of validity and reliability in the Peruvian context, supporting its use with pediatric patients.
Health information analysis of cryptorchidism-related short videos: Analyzing quality and reliability
Authors: Sun Yuqiang , Liu Xingjian , Zhang Xintao , Xu Qiongqian , Li Aiwu 
Published: January 2025

Objective Cryptorchidism is a common congenital anomaly in children. Short video content has increased awareness and urged timely intervention, but there is a lack of understanding about the quality and reliability of these videos. This survey assesses the quality and credibility of cryptorchidism-related videos on Chinese short video platforms to ensure accurate information for caregivers and healthcare professionals. Methods We analyzed 228 videos from TikTok, Bilibili, and Kwai on 16 May 2024. Using the Journal of the American Medical Association (JAMA) criteria, Global Quality Score (GQS), and modified DISCERN score, we evaluated the videos based on six factors: definition, risk factors, symptoms, tests, treatment, and outcome. Results Video quality varied significantly across platforms ( P = .03). Medical professionals’ videos had higher JAMA scores than those by nonmedical professionals ( P < .001), but no significant differences were found in GQS ( P = .633) or modified DISCERN scores ( P = .853). Overall, video quality was suboptimal, focusing mainly on treatment, symptoms, and prognosis, while neglecting tests and risk factors. Longer videos correlated with higher GQS ( r = .34, P < .001) and modified DISCERN scores ( r = .39, P < .001), while newer videos were of higher quality (GQS: r = −.19, P < .005; modified DISCERN: r = −.25, P < .001). Higher engagement (comments: r = −.16, P = .01; shares: r = −.18, P = .04) was associated with lower quality. Conclusion Overall, the videos’ quality and reliability were moderate, with professional content providing more accurate insights. This highlights the need for improved regulation of medical information on short video platforms.
Exploring Emerging Adulthood(s) in India
Authors: Mitra Deeya , Arnett Jeffrey Jensen 
Published: January 2025

The current study investigated emerging adulthood in India using a survey design ( N = 342, Mage = 24.33 years) including the Inventory of Dimensions of Emerging Adulthood (Reifman et al., 2007) and the Flourishing scale (Diener et al., 2010). Most participants endorsed the characteristics of emerging adulthood as representative of the current time of their life. Self-focus was the highest rated, followed by emerging adulthood being a time of possibilities, identity explorations, feeling-in-between, instability, and finally, other-focus. Latent Profile Analysis was applied to identify meaningful sub-groups based on similar characteristics and rating patterns. Four profiles were determined for IDEA: s tall, moderate, transitional time/relational, and transitional time/self-focus. All profiles scored high on the Flourishing scale. A univariate analysis depicted that well-being levels were significantly different across the profiles. Findings were consistent with previous research and added unique insights indicative of sociocultural differences based on gender, socioeconomic class, and urban-rural locations.
Risk Factors Preventing Identification of the Microorganism Causing Vertebral Osteomyelitis
Authors: Sakamoto Yushi , Onishi Eijiro , Mitsuzawa Sadaki , Ota Satoshi , Takeuchi Hisataka , Tsukamoto Yoshihiro , Yamashita Shinnosuke , Tanaka Atsushi , Saito Ryohei , Yasuda Tadashi 
Published: January 2025

Study Design Retrospective study. Objective To elucidate the factors influencing the identification of causative microorganisms in vertebral osteomyelitis (VO) and the effectiveness of different culture methods in increasing the identification rate. Methods A total of 252 patients diagnosed with and treated for VO at a single hospital were enrolled. The results of various culture methods were reviewed along with the clinical data of the patients retrospectively. Results Microbiological diagnosis was achieved in 210 out of 252 patients (83.3%). Diagnostic percentages of blood cultures, CT-guided drainage, fluoroscopic disc biopsy, and intraoperative specimens were 73.6%, 73.9%, 27.6%, and 50.8%, respectively. Staphylococcus aureus was the most common pathogen (85 cases, 40.5%). Higher White Blood Cell (WBC) count, lower serum albumin (ALB) level, epidural abscess, and absence of prior antibiotic exposure were significant predictors of positive culture results across all culture methods. Prior antibiotic exposure was the most significant predictor of negative outcomes (OR 0.24). Blood culture results correlated with body temperature, C-reactive protein (CRP), ALB, and prior antibiotic exposure. A shorter duration of antibiotic administration before culture was associated with an increased likelihood of positive blood culture results. Conclusions This study demonstrated that laboratory findings indicating a high inflammatory response (elevated WBC count, CRP level, and body temperature), lower ALB level, presence of epidural abscess, absence of prior antibiotic exposure, and shorter duration of antibiotics were significant predictors of positive culture results. Blood cultures should be conducted in the presence of high inflammation levels to improve microorganism identification rates.
Chronic Kidney Disease Preventive Attitude, Practice, and Associated Factors among Type 2 DM Patients in Ethiopia: A Cross-Sectional Study
Authors: Wake Addisu Dabi , Dinsa Sena Babsa 
Published: January 2025

Introduction Globally, chronic kidney disease (CKD) has emerged as one of the leading causes of mortality and it is one of a small number of noncommunicable diseases that have shown an increase in associated deaths over the past two decades. Chronic kidney disease affects approximately 50% of patients with type 2 diabetic mellitus (DM). Objective To determine CKD preventive attitude, practices, and associated factors among type 2 DM (T2DM) patients attending follow-up in a diabetic clinic at Asella Referral and Teaching Hospital. Methods Institutional based cross-sectional study was conducted at Asella Referral and Teaching Hospital among T2DM patients from December 23, 2021, to January 23, 2022. Data were entered into EpiData 4.2.00 and analyzed by Statistical Package for the Social Sciences version 23.0. Result A total of 216 study participants were included in to this study. The level of good preventive attitude and practice toward CKD among T2DM patients were 61.6% ( n = 133, 95% CI: 55.6–68.0) and 54.6% ( n = 118, 95% CI: 47.7–60.6), respectively. Age (50–59 years) (adjusted odds ratio [AOR] = 0.351, 95% CI: 0.125–0.988, p = .047), married (AOR = 4.423, 95% CI: 1.366–14.314, p = .013), urban residents (AOR = 0.321, 95% CI: 0.152–0.680, p = .003), and governmental employed (AOR = 0.269, 95% CI: 0.076–0.954, p = .042) were significantly associated with CKD preventive attitude. Formal education (AOR = 1.686, 95% CI: 1.416–5.502, p = .043), an average monthly income of ≥8000 ETB (AOR = 4.048, 95% CI: 1.129–14.520, p = .032), family history of CKD (AOR = 1.417, 95% CI: 1.231–7.136, p = .045) were significantly associated with CKD preventive practice. Conclusion The level of good preventive attitude and practice toward CKD among T2DM patients was 61.6% and 54.6%, respectively. Age, marital status, residence, and occupation were significantly associated with good preventive attitude of T2DM patients. Whereas educational status, average monthly income, and duration since diagnosed with T2DM were significantly associated with good CKD preventive practice. Health educational program needs to occur to improve the preventive attitude and practice toward CKD among T2DM patients.
The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon
Authors: Zou Lu , Cao Dan , Sun Qing , Yu Wenjun , Li Bingzong , Xu Guoqiang , Zhou Liang 
Published: January 2025

Abstract

Background
The protein cereblon (CRBN) mediates the antileukemia effect of lenalidomide (Len). Len binds to CRBN, recruits IKZF1/IKZF3, and promotes their ubiquitination and degradation, through which Len exhibits its antileukemia and antimyeloma activity. Therefore, the protein level of CRBN might affect the antiproliferative effect of Len. In this study, we explored the interactome for CRBN using proximity labeling technique TurboID and quantitative proteomics, and then investigated the antileukemia effect of Len.

Methods
The primary acute myeloid leukemia (AML) cells and AML cell lines were used to explore the functions of histone demethylase KDM5C on the antileukemia effect of Len. The cell viability and CRBN protein levels were evaluated in these cell lines. In addition, the KDM5C inhibitors were used to determine the effects of KDM5C enzymatic activity on the viability of AML cell lines.

Results
We identified that histone demethylase KDM5C was a CRBN-interacting protein. Biochemical experiments found that the CRBN-interacting protein KDM5C could stabilize CRBN and enhance the antileukemia effect of Len in an enzyme activity-independent manner. Furthermore, our studies revealed that the small-molecule compound MLN4924 could increase CRBN by elevating KDM5C.The combination of MLN4924 and Len can further increase the sensitivity of primary AML cells and AML cell lines to Len.

Conclusions
This study provides a possible strategy for a combination treatment with MLN4924 and Len for leukemia.
Parental perception of male circumcision: a local cross sectional study in a Muslim community
Authors: Al-Maghlouth Abdullatif K. , Zakaria Ossama M. 
Published: January 2025

Abstract

Background
Male circumcision is regarded as one of the oldest and widely conducted surgical procedures. It entails partial or total removal of the prepuce skin. Recent human rights advocates have a higher dispute as regards circumcision. However, controversy still exists regarding the necessity of the procedure. The opponent considers it against human rights. On the other hand, supporters claim its hygiene and advantages in preventing urinary tract infections, sexually transmitted illnesses, and human immunodeficiency virus.

Methods
A specially designed anonymous cross-sectional questionnaire was distributed randomly among participants of a local Muslim community. Information such as sociodemographic characteristics, medical history, knowledge about male circumcision, and sources of information were collected. The collected data were statistically analyzed via the Statistical Packages for Software Sciences (SPSS) version 26.0.

Results
Four hundred and forty participated in the current study. The most commonly agreed upon indication for male circumcision by the participants was religion (88.4%). They considered it as a holy obligation. Circumcision-related hemorrhage was recognized as the most prevalent circumcision complication, followed by adhesions and infections. Overall, the majority of respondents were aware of the procedure itself, although a respectable percentage of participants (85%) supported the male circumcision.

Conclusion
The majority of the participants supported male circumcision as an obligatory religious deed. Moreover, they do believe in its medical benefits. Extra studies with larger cohort are needed for more reliable and realistic conclusions in the Islamic culture about male circumcision.
Challenges and adaptations in pancreatic cancer surgery during the COVID-19 pandemic in a high-volume center
Authors: Al-Saeedi Mohammed , Ramouz Ali , Khajeh Elias , Shraim Sakher , Werba Alexander , Polychronidis Georgios , Mehrabi Arianeb , Loos Martin 
Published: January 2025

Abstract

Background
The COVID-19 pandemic affected healthcare systems worldwide, disrupting elective surgeries including those for cancer treatment. This study examines the effects of the pandemic on outcomes of pancreatic cancer surgeries at a specialized high-volume surgery center.

Materials and methods
This study compared surgical volume and outcomes of pancreas resections between the pre-pandemic (January 2019 to February 2020), early pandemic (March 2020 to January 2021), and late pandemic (February 2021 to December 2021) periods. Perioperative and postoperative data were retrospectively analyzed from a prospectively maintained database together with surgical complications, mortality rates, and hospital stays.

Results
There was no significant reduction in the number of pancreas resections performed during the pandemic. The rate of primary resectable tumors was significantly lower during the late pandemic phase (66% vs. 65.9% vs. 56.5%; P = 0.024), and subsequently application of neoadjuvant therapies increased in the late pandemic phase (26% vs. 25.4% vs. 33.8%; P = 0.079). The number of chemotherapy cycles were also higher during the late pandemic phase (P = 0.009). Surgical complication rates were higher during the late pandemic phase (47.8% vs. 45.6% vs. 56%; P = 0.043), but mortality rates remained low (30-day mortality: 1.6% vs. 1% vs. 3.7%, P = 0.116; 90-day mortality: 2.5% vs. 1.6% vs. 3.7%, P = 0.296).

Conclusion
Our results indicate effective management of pancreatic cancer despite the challenges presented by the pandemic. These findings suggest that centralized, specialized surgical centers can maintain high-quality care of patients with pancreatic cancer during crises like the COVID-19 pandemic. These findings underscore the importance of timely surgical interventions for cancer patients, even when the healthcare system is disrupted.
Intention to utilize mental health and suicide prevention resources in a community sample during the first year of the COVID-19 pandemic
Authors: Cohen Lisa J. , El Hayek Rawad , Imbastaro Benedetta , Goncearenco Inna , Zheng Sifan , Rogers Megan L. , Pompilli Maurizio , Galynker Igor 
Published: January 2025

Abstract

Objective
Given the stressors experienced during the COVID-19 pandemic, it is critical to identify populations with elevated mental health needs during this crisis. This study investigated demographic correlates of reported intention to utilize mental health (MH) and suicide prevention (SP) resources in a community sample during the COVID-19 pandemic.

Methods
A sample of 1,978 adults in the United States completed an anonymous online survey between June 2020 and February 2021.

Results
Intent to utilize MH resources was associated with younger age, single marital status, female gender, and Hispanic vs. White race/ethnicity. Intent to utilize SP resources was associated with younger age, single marital status, and was greater among Black and Hispanic vs. White race/ethnicity. Lower education was associated with MH and SP utilizers in bivariate analysis. Indirect effects of Suicide Crisis Syndrome (SCS) symptoms were found on the association of age, gender, and marital status with MH utilization and of age, marital status, and education with SP Utilization.

Conclusions
Specific demographic populations demonstrate greater interest in mental health care during the COVID-19 pandemic. These help-seeking patterns can be explained in part by an elevated level of SCS symptoms, suggesting greater levels of distress were driving expressed intention to utilize service referrals.
Visual hermeneutics as a tool to introduce empathy and core physician attributes in doctor-patient relationship for first-year medical undergraduate students
Authors: Prabhath Sushma , Kulkarni Uma , Lakshmi R. Vani , Patra Bikash , K. Eshwari , Prabhu Divya Arvind , Nayak Kirtana R. 
Published: January 2025

Abstract

Background
The doctor-patient relationship is essential for effective patient care, yet medical education often neglects to nurture the quality such as empathy during the initial years of training. Doctor-patient relationship is one of the modules taught in first year as part of mandatory AETCOM (Attitude, Ethics, and Communication) course in the undergraduate Indian medical curriculum. Hermeneutics, a method of interpretation, can play a vital role in introducing observational and reflective thinking skills. This study aimed to introduce empathy concepts and attributes of a good physician to first-year medical students through the use of paintings and visual hermeneutics to enhance their understanding of the doctor-patient relationship.

Methods
A newly developed and validated educational module on the “Doctor-patient relationship” was administered to 250 first-year undergraduate medical students at Kasturba Medical College Manipal. The session was structured into three key steps:

Introduction
Presenting Sir Luke Fildes’ famous painting, The Doctor.

Self-understanding and interpretation
Encouraging students to analyse and interpret the painting.

Debriefing
Facilitating discussions to consolidate learning. The session’s effectiveness was evaluated using the initial two levels of the Kirkpatrick evaluation model. The learners feedback regarding the usefulness of the session was captured using a validated questionnaire, while reflective writing assignments were used to explore students’ learnings from the intervention.

Results
Student feedback was overwhelmingly positive, with participants expressing that the session significantly enhanced their understanding of professional qualities and empathy in the doctor-patient relationship, rating their overall learning experience at 8.63 out of 10. Students expressed that the use of painting and interactive discussions greatly enriched their capacity to connect with emotional and ethical dimensions of medical practice. Reflective writing revealed the importance of building trust, demonstrating professional conduct, and maintaining empathy and compassion in clinical interactions.

Conclusion
Introducing a visual hermeneutics approach has the potential to cultivate empathy and foster a deeper understanding of the doctor-patient relationship. Introducing this approach during the formative years of medical training can nurture compassionate and virtuous conduct, reinforcing students’ commitment to delivering empathetic and competent care throughout their medical careers.

Trial registration
The institutional ethics committee approved the conduct of the study [IEC180/2023].