bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI PENDIDIKAN ISLAM MULTIKULTURAL SEBAGAI UPAYA MENGATASI BIAS GENDER-BUDAYA DI DUNIA PENDIDIKAN
Authors: Setiawan Yudhi , Hulaefi Hulaefi , Musari Musari , Mareta Mira , Rabbani Syarifah Aulia 
Published: December 2023

Penelitian ini bertujuan memaparkan fenomena bias gender dan budaya yang sering terjadi di dalam lingkungan sekolah dan penerapan teori ekologi dan pendidikan Islam multikultural sebagai solusi untuk mengatasinya. Studi penelitian ini menggunakan jenis penelitian kepustakaan dengan cara mengumpulkan dan menganalisis teks atau dkoumen yang relevan dengan pembahasan yang akan diulas. Gender merujuk pada peran laki-laki dan perempuan dalam masyarakat sedangakan budaya merupakan pola perilaku dan tingkah laku yang diwariskan dari satu generasi ke generasi berikutnya. Saat ini, banyak ditemukan ketimpangan budaya dan gender di lingkungan sekolah baik perlakuan budaya guru terhadap peserta didik yang memilki latar belakang berbeda maupun modul pelajaran yang memarginalisasi peran perempuan. Hasil penelitian menunjukkan bahwa konsep pendidikan Islam multikultural dapat digunakan seorang pendidik dalam memahami keankearagaman budaya dan perbedaan gender yang terjadi di dunia pendidikan sehingga proses pembelajaran bisa berjalan sesuai rencana serta menekan terhadap peserta didik agar dapat memahami, menerima dan menghargai nilai yang berbeda-beda dari orang, suku, dan budaya yang berbeda sesuai dengan konteks yang ada pada al-Qur’an dan Sunnah.
Penetrating Facial Trauma Resulting in Loss of Sense
Authors: Petrus Asan , Zansen Jakaria 
Published: December 2023

Introduction. Clinical forensic medicine interacts between the law, the judiciary and the police involving living and dead people with the issuance of a visum et repertum. A wound is damage to a part of the body in the form of a break in the integrity of the tissue that can occur due to mechanical violence. The eye organ is particularly vulnerable to injury, which can be fatal and lead to blindness. Trauma is the leading cause of unilateral blindness. Approximately 3 million cases of ocular and orbital trauma occur in the United States each year. An estimated 20,000 to 68,000 of these cases are visually impairing and approximately 40,000 have significant vision loss. Objective. To review forensic and medicolegal cases of sharp facial trauma to sensory loss. Case Illustration. Reported a case of stabbing a woman who was riding a motorcycle with the intention of the perpetrator to seize the victim's motorcycle. Discussion. the results of the examination, the victim is a woman, 54 years old, the patient's general condition is good, cooperative compos mentis consciousness, and examination of vital signs within normal limits. On examination, there were stab wounds on the face covering the forehead, nose and right cheek to the right eyeball due to sharp trauma. It was confirmed that the condition of the victim's left eye was categorized as blind, the eye could not see anymore because the eyeball had been cut and bleeding occurred so that the removal of the eyeball organ had to be done to avoid complications from the injury, but in this case the victim refused to take this action. Conclusion. Based on this injury, the victim suffered a loss of vision. This case constitutes serious injury pursuant to Article 90 of the Penal Code and the suspect is charged under Article 355 of the Penal Code.
Key Point: Forensic and Medicolegal, Loss of Sense, Penetrating Facial Trauma
A Study on Dilatation Monotone Maps and the Haezendonck-Goovaerts Risk Measure
Authors: Rahnemaye Rahsepar Seyedeh Massoomeh 
Published: December 2023

<p>Risk measures have been studied for several decades in the ﬁnancial literature. Mathematically, a risk measure is a mapping from a class of random variables deﬁned on some space X to the (extended) real line. It is difﬁcult to give a reliable assessment of ﬁnancial risk without a suitable model space X where the ﬁnancial position lies there. </p>
<p>In this work, we assume the domain <em>X</em> for the risk measure <em>ρ : X</em> → (−∈,∈] is a subset of <em>L</em><sup>1</sup> that contains the space of simple random variables L and has the Fatou property. We focus on dilatation monotonicity as desirable preferences of the decision-maker over risks. We discuss continuity properties of dilatation monotone risk measures on <em>X</em>. We prove that on a non-atomic probability space, every dilatation monotone convex risk measure on <em>X</em> can extend uniquely to a σ(<em>L</em><sup>1</sup>,L)-lower semicontinuous dilatation monotone convex risk measure. Our ﬁndings complement extension and continuity results for (quasi)convex law-invariant functionals. </p>
<p>In the second part of this thesis, we overview various properties of the Haezendonck–Goovaerts risk measure as a dilatation monotone risk measure. In the special case <em>Φ(x) = x</em><sup><em>2</em></sup>, we develop an explicit expression for the Haezendonck–Goovaerts risk measure when the risk variable <em>X</em> follows some speciﬁc distributions and propose an empirical algorithm to estimate this risk measure. Moreover, we investigate the performance of some members of this class of risk measures on real data as a possible application of the Haezendonck-Goovaerts risk measure. </p>
ENFRENTAMENTO DA PANDEMIA E ORIENTAÇÕES PARA AS PRÁTICAS PEDAGÓGICAS NO ENSINO MÉDIO: QUAIS AS INDICAÇÕES DO ESTADO DE SANTA CATARINA?
Authors: Voigt Jane Mery Richter , Corrêa Shirlei de Souza , Oliveira Gabriel Blasius Sutil de 
Published: December 2023

O objetivo deste artigo é identificar as temáticas dos materiais disponibilizados no site da Secretaria de Estado das Educação de Santa Catarina - SED, uma das fontes de orientação para as práticas pedagógicas de professores do Ensino Médio durante a pandemia. O referencial teórico se pauta em autores que discutem políticas curriculares do Ensino Médio e o uso das tecnologias digitais da informação e comunicação. De abordagem qualitativa, a pesquisa exploratória foi realizada a partir de análise documental, contemplando os materiais disponíveis no site da SED. Os resultados revelam que os professores foram instrumentalizados pelas ferramentas digitais do Google for Education e por meio de webinários de formação. Percebe-se uma fragilidade com relação a formação de professores do Ensino Médio nesse período, o que minimiza as recentes discussões em pauta no país referentes às politicas curriculares para o novo Ensino Médio, e que propõe abertura às parcerias público privadas.
Palavras-chave: Ensino Médio. Prática Educativa. Tecnologias digitais da Informação e Comunicação. Pandemia.

ABSTRACT
The objective of this article is to identify the themes of the materials available on the website of the State Department of Education of Santa Catarina – SED, one of the sources of guidance for the pedagogical practices of high school teachers during the pandemic. The theoretical framework is based on authors who discuss high school curriculum policies and the use of digital information and communication technologies. With a qualitative approach, the exploratory research was carried out based on documentary analysis, considering the materials available on the SED website. The results reveal that teachers were equipped with digital tools from “Google for Education” and through training webinars. There is a perceived weakness in relation to the training of high school teachers during this period, which minimizes the recent discussions on the agenda in the country regarding curricular policies for the nw high school, and which proposes openness to public-private partnership.
Keywords: High School. Educational Practices. Digital Information and Communication Technologies. Pandemic.
SILÊNCIO COMO O SER DA LINGUGAGEM NA LITERATURA MODERNA
Authors: Machado Carlos Henrique 
Published: December 2023

Se a linguagem é responsável por garantir a existência do sujeito que percebe, abstrai e diz o mundo à sua volta, garantido a identidade e a diferença das coisas, a literatura moderna, em alguns de seus aspectos, fez desaparecer aquilo que servia de suporte ao ato linguístico, ao falante e ao seu discurso. O sujeito ou o eu que fala se fragmentou e se dispersou até desaparecer num espaço vazio de profundo silêncio, longe dos significados da língua e da dinastia da representação. Queremos perceber, então, de que modo se dá esta dissolução a partir de um texto de Kafka de 1917 (O silêncio das sereias), que vem revelar os diferentes sentidos por intermédio de uma linguagem descentrada, única, capaz de dar a perceber aquilo que escapa à legislação das palavras. Queremos penetrar os lugares do silêncio onde os encontros de tendências intempestivas produzem agitações, que antes de poderem ser designadas se transmutam em uma novidade quando o momento pathico é experimentado no mundo como acontecimento.
Profiles of biliary microbiota in biliary obstruction patients with Clonorchis sinensis infection
Authors: Chen Rui , Li Xiang , Ding Jian , Wan Jie , Zhang Xueli , Jiang Xu , Duan Shanshan , Hu Xinyi , Gao Yannan , Sun Beibei , Lu Xi , Wang Ruifeng , Cheng Yang , Zhang Xiaoli , Han Su 
Published: December 2023

BackgroundClonorchis sinensis (C. sinensis) is a epidemiologically significant food-borne parasite, causing several hepatobiliary diseases. Biliary microbiota community structure might be influenced by infection with pathogens. However, the biliary microbiome of biliary obstruction patients infected with C. sinensis is still an unexplored aspect.MethodsA total of 50 biliary obstruction patients were enrolled, including 24 infected with C. sinensis and 26 non-infected subjects. The bile samples were collected by Endoscopic Retrograde Cholangiopancretography. Biliary microbiota alteration was analyzed through high-throughput 16S ribosomal RNA (rRNA) gene sequencing.ResultsOur findings revealed that there was significant increase in both richness and diversity, as well as changes in the taxonomic composition of the biliary microbiota of C. sinensis infected patients. At the phylum level, C. sinensis infection induced Proteobacteria increased and Firmicutes reduced. At the genus level, the relative abundance of Pseudomonas and Staphylococcus increased significantly, while Enterococcus decreased prominently in infected groups (P &lt; 0.05). The PICRUSt analysis further showed remarkably different metabolic pathways between the two groups.ConclusionC. sinensis infection could modify the biliary microbiota, increasing the abundance and changing the phylogenetic composition of bacterial in biliary obstruction patients. This study may help deepen the understanding of the host-biliary microbiota interplay with C. sinensis infection on the background of biliary obstruction and provide new insights into understanding the pathogenesis of clonorchiasis.
Embryonic diapause due to high glucose is related to changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism
Authors: Hong Jiewei , Tong Hongxuan , Wang Xuan , Lv Xiaoyan , He Lijuan , Yang Xuezhi , Wang Yingli , Xu Kaixia , Liang Qi , Feng Qianjin , Niu Tingli , Niu Xin , Lu Yu 
Published: December 2023

IntroductionThe adverse effects of high glucose on embryos can be traced to the preimplantation stage. This study aimed to observe the effect of high glucose on early-stage embryos. Methods and resultsSeven-week-old ICR female mice were superovulated and mated, and the zygotes were collected. The zygotes were randomly cultured in 5 different glucose concentrations (control, 20mM, 40mM, 60mM and 80mM glucose). The cleavage rate, blastocyst rate and total cell number of blastocyst were used to assess the embryo quality. 40 mM glucose was selected to model high glucose levels in this study. 40mM glucose arrested early embryonic development, and the blastocyst rate and total cell number of the blastocyst decreased significantly as glucose concentration was increased. The reduction in the total cell number of blastocysts in the high glucose group was attributed to decreased proliferation and increased cell apoptosis, which is associated with the diminished expression of GLUTs (GLUT1, GLUT2, GLUT3). Furthermore, the metabolic characterization of blastocyst culture was observed in the high-glucose environment. DiscussionThe balance of glycolysis and oxidative phosphorylation at the blastocyst stage was disrupted. And embryo development arrest due to high glucose is associated with changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism.
Platelet-rich plasma for the treatment of diabetic foot ulcer: a systematic review
Authors: OuYang Hong , Tang Yi , Yang Fan , Ren Xin , Yang Jing , Cao Hongyi , Yin Yifan 
Published: December 2023

BackgroundWith the increasing incidence of diabetes, diabetic foot ulcer(DFU) has become one of the most common and serious complications in people with diabetes. DFU is associated with significant morbidity and mortality, and can also result in significant economic, social and public health burdens. Due to peripheral neuropathy, peripheral vascular disease, hyperglycemic environment, inflammatory disorders and other factors, the healing of DFU is impaired or delayed, resulting in the formation of diabetic chronic refractory ulcer. Because of these pathological abnormalities in DFU, it may be difficult to promote wound healing with conventional therapies or antibiotics, whereas platelet-rich plasma(PRP) can promote wound healing by releasing various bioactive molecules stored in platelets, making it more promising than traditional antibiotics. Therefore, the purpose of this systematic review is to summarize and analyze the efficacy of PRP in the treatment of DFU.MethodsA literature search was undertaken in PubMed, CNKI, EMB-ASE, the Cochrane Library, the WanFang Database and the WeiPu Database by computer. Included controlled studies evaluating the efficacy of PRP in the treatment of diabetic foot ulcers. The data extraction and assessment are on the basis of PRISMA.ResultsTwenty studies were evaluated, and nineteen measures for the evaluation of the efficacy of PRP in DFU treatment were introduced by eliminating relevant duplicate measures. The efficacy measures that were repeated in various studies mainly included the rate of complete ulcer healing, the percentage of ulcer area reduction, the time required for ulcer healing, wound complications (including infection rate, amputation rate, and degree of amputation), the rate of ulcer recurrence, and the cost and duration of hospitalization for DFU, as well as subsequent survival and quality of life scores. One of the most important indicators were healing rate, ulcer area reduction and healing time. The meta-analysis found that PRP was significantly improve the healing rate(OR = 4.37, 95% CI 3.02-6.33, P &lt; 0.001) and shorten the healing time(MD = -3.21, 95% CI -3.83 to -2.59,P &lt; 0.001)of patients with DFU when compared to the conventional treatment, but there was no significant difference in reducing the of ulcer area(MD = 5.67, 95% CI -0.77 to 12.11,P =0.08&gt;0.05 ).ConclusionThe application of PRP to DFU can improve ulcer healing rate and shorten ulcer healing time, but more clinical data are needed to clarify some efficacy measures. At the same time, a standardized preparation process for PRP is essential.
Gene signatures associated with prognosis and chemotherapy resistance in glioblastoma treated with temozolomide
Authors: Carter Tonia , Valenzuela Robert K. , Yerukala Sathipati Srinivasulu , Medina-Flores Rafael 
Published: December 2023

Background:Glioblastoma (GBM) prognosis remains extremely poor despite standard treatment that includes temozolomide (TMZ) chemotherapy. To discover new GBM drug targets and biomarkers, genes signatures associated with survival and TMZ resistance in GBM patients treated with TMZ were identified.Methods:GBM cases in The Cancer Genome Atlas who received TMZ (n= 221) were stratified into subgroups that differed by median overall survival (mOS) using network-based stratification to cluster patients whose somatic mutations affected genes in similar modules of a gene interaction network. Gene signatures formed from differentially mutated genes in the subgroup with the longest mOS were used to confirm their association with survival and TMZ resistance in independent datasets. Somatic mutations in these genes also were assessed for an association with OS in an independent group of 37 GBM cases.Results:Among the four subgroups identified, subgroup four (n= 71 subjects) exhibited the longest mOS at 18.3 months (95% confidence interval: 16.2, 34.1;p= 0.0324). Subsets of the 86 genes that were differentially mutated in this subgroup formed 20-gene and 8-gene signatures that predicted OS in two independent datasets (Spearman’s rho of 0.64 and 0.58 between actual and predicted OS;p&lt; 0.001). Patients with mutations in five of the 86 genes had longer OS in a small, independent sample of 37 GBM cases, but this association did not reach statistical significance (p= 0.07). Thirty-one of the 86 genes formed signatures that distinguished TMZ-resistant GBM samples from controls in three independent datasets (area under the curve ≥ 0.75). The prognostic and TMZ-resistance signatures had eight genes in common (ANG,BACH1,CDKN2C,HMGA1,IFI16,PADI4,SDF4, andTP53INP1). The latter three genes have not been associated with GBM previously.Conclusion:PADI4,SDF4, andTP53INP1are novel therapy and biomarker candidates for GBM. Further investigation of their oncologic functions may provide new insight into GBM treatment resistance mechanisms.
Effects of novel coronavirus Omicron variant infection on pregnancy outcomes: a retrospective cohort study from Guangzhou
Authors: Xiao Huanshun , Chen Cheng , Huang Shan , Zhang Wenni , Cai Shuangming , Hou Xiangling , Luo Yiping , Lin Yu 
Published: December 2023

ObjectiveSince 2022, Omicron has been circulating in China as a major variant of the novel coronavirus, but the effects of infection with Omicron variants on pregnant women and newborns are unknown. The purpose of this study was to determine the clinical characteristics of Omicron infection during pregnancy and its effect on pregnancy outcomes.MethodsThis study retrospectively analyzed the data of 93 confirmed cases of novel coronavirus infection and 109 non-infected patients admitted to the isolation ward of Guangdong Maternal and Child Health Hospital from December 1, 2022 to January 31, 2023, and statistically analyzed the clinical features of Omicron variant infection during pregnancy and its impact on pregnancy outcomes. Further effects of underlying diseases on Omicron infection in pregnant women were analyzed.ResultsThe incubation period of COVID-19 infection was 0.99±0.86 days, 94.38% of patients had fever or other respiratory symptoms, the lymphocyte count in the infected group was lower than that in the uninfected group, and the lymphocyte count was further reduced in the patients with pregnancy complications or complications. Compared with the uninfected group, APTT and PT were prolonged, platelet count and fibrinogen were decreased in the infected group, all of which had statistical significance. COVID-19 infection during pregnancy increased the rate of cesarean section compared to uninfected pregnant patients, and COVID-19 infection in gestational diabetes resulted in a 4.19-fold increase in cesarean section rate. There was no statistically significant difference in gestational age between the two groups. The incidence of intrauterine distress, turbidity of amniotic fluid and neonatal respiratory distress were higher in the infection group. No positive cases of neonatal COVID-19 infection have been found.ConclusionThe patients infected with omicron during pregnancy often have febrile respiratory symptoms with lymphocyopenia, but the incidence of severe disease is low. Both Omicron infection and gestational diabetes further increase the incidence of cesarean section, and this study found no evidence of vertical transmission of Omicron.
Metabolomic signatures of intestinal colonization resistance against Campylobacter jejuni in mice
Authors: Shayya Nizar W. , Bandick Rasmus , Busmann Lia V. , Mousavi Soraya , Bereswill Stefan , Heimesaat Markus M. 
Published: December 2023

IntroductionCampylobacter jejuni stands out as one of the leading causes of bacterial enteritis. In contrast to humans, specific pathogen-free (SPF) laboratory mice display strict intestinal colonization resistance (CR) against C. jejuni, orchestrated by the specific murine intestinal microbiota, as shown by fecal microbiota transplantation (FMT) earlier.MethodsMurine infection models, comprising SPF, SAB, hma, and mma mice were employed. FMT and microbiota depletion were confirmed by culture and culture-independent analyses. Targeted metabolome analyses of fecal samples provided insights into the associated metabolomic signatures.ResultsIn comparison to hma mice, the murine intestinal microbiota of mma and SPF mice (with CR against C. jejuni) contained significantly elevated numbers of lactobacilli, and Mouse Intestinal Bacteroides, whereas numbers of enterobacteria, enterococci, and Clostridium coccoides group were reduced. Targeted metabolome analysis revealed that fecal samples from mice with CR contained increased levels of secondary bile acids and fatty acids with known antimicrobial activities, but reduced concentrations of amino acids essential for C. jejuni growth as compared to control animals without CR.DiscussionThe findings highlight the role of microbiota-mediated nutrient competition and antibacterial activities of intestinal metabolites in driving murine CR against C. jejuni. The study underscores the complex dynamics of host-microbiota-pathogen interactions and sets the stage for further investigations into the mechanisms driving CR against enteric infections.
Semi-automated motor hotspot search (SAMHS): a framework toward an optimised approach for motor hotspot identification
Authors: Agboada Desmond , Osnabruegge Mirja , Rethwilm Roman , Kanig Carolina , Schwitzgebel Florian , Mack Wolfgang , Schecklmann Martin , Seiberl Wolfgang , Schoisswohl Stefan 
Published: December 2023

BackgroundMotor hotspot identification represents the first step in the determination of the motor threshold and is the basis for the specification of stimulation intensity used for various Transcranial Magnetic Stimulation (TMS) applications. The level of experimenters’ experience and the methodology of motor hotspot identification differ between laboratories. The need for an optimized and time-efficient technique for motor hotspot identification is therefore substantial.ObjectiveWith the current work, we present a framework for an optimized and time-efficient semi-automated motor hotspot search (SAMHS) technique utilizing a neuronavigated robot-assisted TMS system (TMS-cobot). Furthermore, we aim to test its practicality and accuracy by a comparison with a manual motor hotspot identification method.MethodA total of 32 participants took part in this dual-center study. At both study centers, participants underwent manual hotspot search (MHS) with an experienced TMS researcher, and the novel SAMHS procedure with a TMS-cobot (hereafter, called cobot hotspot search, CHS) in a randomized order. Resting motor threshold (RMT), and stimulus intensity to produce 1 mV (SI1mV) peak-to-peak of motor-evoked potential (MEP), as well as MEPs with 120% RMT and SI1mV were recorded as outcome measures for comparison.ResultsCompared to the MHS method, the CHS produced lower RMT, lower SI1mV and a trend-wise higher peak-to-peak MEP amplitude in stimulations with SI1mV. The duration of the CHS procedure was longer than that of the MHS (15.60 vs. 2.43 min on average). However, accuracy of the hotspot was higher for the CHS compared to the MHS.ConclusionsThe SAMHS procedure introduces an optimized motor hotspot determination system that is easy to use, and strikes a fairly good balance between accuracy and speed. This new procedure can thus be deplored by experienced as well as beginner-level TMS researchers.