bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction by caterpillars of stored and emitted volatiles in terpene chemotypes from populations of wild cotton (Gossypium hirsutum)
Authors: Mamin Marine , Clancy Mary V. , Flückiger Galien , Quijano-Medina Teresa , Pérez-Niño Biiniza , Abdala-Roberts Luis , Turlings Ted C. J. , Bustos-Segura Carlos 
Published: January 2025

Abstract

Background
Upland cotton (Gossypium hirsutum) plants constitutively store volatile terpenes in their leaves, which are steadily emitted at low levels. Herbivory leads to a greater release of these stored volatiles. Additionally, damaged plants increase the accumulation of volatile terpenes in their leaves and begin to synthesize and emit other terpenes and additional compounds. This has been well characterised for cultivated G. hirsutum, but little is known about volatile production in response to herbivory in wild populations. We investigated how damage by a generalist herbivore species, the beet armyworm (Spodoptera exigua), affects leaf-stored and emitted volatiles in wild G. hirsutum plants and compared the responses of two known chemotypes. Wild cotton plants were grown in a greenhouse from seeds collected from four distinct locations covering sixteen populations, along the Yucatan coast (Mexico), from where this cotton species originates. We assessed whether the differences in leaf terpene profiles between the two chemotypes persisted upon herbivory, in leaves and in headspace emissions, and whether these chemotypes also differed in the production and release of herbivory-induced volatiles. In addition to chemotypic variation, we further investigated intraspecific variation in the volatile response to herbivory among genotypes, populations, and the four geographic regions.

Results
The difference between the two chemotypes persisted after herbivory in the stored volatile profile of induced leaves, as well as in the emissions from damaged plants. Therefore, wild cotton chemotypes may differ in their airborne interactions with their environment. The specific terpenes distinguishing these chemotypes showed a weak inducibility, raising questions about their functions. Herbivory triggered changes in stored and emitted volatiles similar to what is known for cultivated varieties of G. hirsutum. However, we report for the first time on the emission of volatile aldoximes by cotton plants, which were only detected in the headspace upon herbivory, and displayed chemotypic and interpopulation variation. Intraspecific variation was also observed in the induced emissions of nitriles and certain terpenes. Moreover, chemotypes differed in their induction of (E)-β-ocimene stored in the leaves.

Conclusions
This comprehensive insight into herbivore-induced volatiles of wild cotton reveals variation in production and emission among populations. A full understanding of their ecological role may help in the development of future pest-management strategies for cotton crops.
Quantifying the potential value of entomological data collection for programmatic decision-making on malaria control in sub-Saharan African settings
Authors: Schmit Nora , Topazian Hillary M. , Pianella Matteo , Charles Giovanni D. , Winskill Peter , Hancock Penelope A. , Sherrard-Smith Ellie , Hauck Katharina , Churcher Thomas S. , Ghani Azra C. 
Published: January 2025

Abstract

Background
The availability of many tools for malaria control leads to complex decisions regarding the most cost-effective intervention package based on local epidemiology. Mosquito characteristics influence the impact of vector control, but entomological surveillance is often limited due to a lack of resources in national malaria programmes.

Methods
This study quantified the monetary value of information provided by entomological data collection for programmatic decision-making using a mathematical model of Plasmodium falciparum transmission. The 3-year impact and cost of various intervention packages was simulated in different sub-Saharan African settings, including combinations of scaling-up insecticide-treated nets (ITN), switching to next-generation ITNs, and a treatment and prevention package. The DALYs averted and their net monetary benefit were compared at different cost-effectiveness thresholds and the value of resolving uncertainty in entomological model parameters was calculated.

Results
Across transmission settings and at cost-effectiveness thresholds over US$170 per DALY averted, the most cost-effective intervention package was switching to and scaling up pyrethroid-pyrrole ITNs combined with the treatment and prevention package. The median expected value of perfect information on the entomological indicators was US$0.05 (range 0.02–0.23) and US$0.17 (range 0.09–1.43) per person at risk at thresholds of US$75 and US$1000 per DALY averted, respectively. This represented less than 2% of the net monetary benefit of implementing the most cost-effective intervention package. Value of information estimates at cost-effectiveness thresholds over US$250 were higher than current investments into entomological monitoring by the US President’s Malaria Initiative.

Conclusions
These results suggest that entomological data collection should not delay implementation of interventions with demonstrated efficacy in most settings, but that sustained investments into and use of entomological surveillance are nevertheless worthwhile and have broad value to national malaria programmes.
Current status and factors influencing kinesiophobia in patients with meniscus injury: a cross-sectional study
Authors: Tang Faqiang , Xu Pan , Jiang Cai , Ke Xiaohua , Huang Dunbing , Dai Yaling , Lin Zhonghua , Wang Shizhong 
Published: January 2025

Abstract

Objectives
This study aimed to examine the relationships between kinesiophobia and injury severity, balance ability, knee pain intensity, self-efficacy, and functional status in patients with meniscus injuries and to identify key predictors of kinesiophobia.

Design
A single-center, prospective cross-sectional study.

Methods
A cross-sectional study involving 123 patients diagnosed with meniscus injuries at Fujian Provincial Hospital was conducted. The knee range of motion test was used to determine limitations in knee joint mobility, whereas magnetic resonance imaging (MRI) was used to assess the severity of meniscus damage. Several validated scales were administered: the Tampa Scale of Kinesiophobia (TSK-17) to measure kinesiophobia, the visual analog scale (VAS) to assess pain intensity, the general self-efficacy scale (GSES) to evaluate self-efficacy, and the Lysholm knee score (LKS) to assess knee functional status. Additionally, balance ability was assessed using the Huber 360 Neuromuscular Control Training and Assessment System (DJO, USA). Spearman’s correlation analysis was applied to explore factors associated with kinesiophobia, whereas simple linear regression analysis was used to identify its predictors.

Results
Among the 123 participants included in the study, 60.16% were identified as experiencing kinesiophobia. Among these participants, 69.10% had grade III meniscus injuries, and 33.3% exhibited limited joint movement. The key clinical characteristics were as follows: the median VAS score was 4 (IQR 2–6), the GSES score was 22 (IQR 20–29), and the LKS score was 45 (IQR 38–55). Kinesiophobia was significantly correlated with injury severity, limited joint movement, pain intensity, self-efficacy, and other functional parameters (P < 0.05). However, no significant correlation was detected between kinesiophobia and limits of stability. Simple linear regression analysis (R²=0.917) revealed several significant predictors of kinesiophobia, including injury severity (β = 2.08), pain intensity (β = 0.882), Romberg quotient (RQ) (β = 3.239), and limited joint movement (β = 0.868). In contrast, self-efficacy (β =-0.455) was negatively associated with kinesiophobia. Furthermore, Grade III injuries and RQ were found to be associated with markedly higher levels of kinesiophobia.

Conclusion
Kinesiophobia is strongly associated with knee injury severity, limited joint movement, RQ, pain intensity, and self-efficacy, which are key predictors. Clinical interventions should focus on these factors to enhance rehabilitation outcomes.
A comprehensive comparison of PARP inhibitors as maintenance therapy in platinum-sensitive recurrent ovarian cancer: a systematic review and network meta-analysis
Authors: Ji Shiya , Chen Lu , Yu Yebo , Chen Xupeng , Wei Liwen , Gou Lili , Shi Cheng , Zhuang Susu 
Published: January 2025

Abstract

Background
PARP inhibitors (PARPis) have shown promising effectiveness for ovarian cancer. This network meta-analysis (PROSPERO registration number CRD42024503390) comprehensively evaluated the effectiveness and safety of PARPis in platinum-sensitive recurrent ovarian cancer (PSROC).

Methods
Articles published before January 6, 2024 were obtained from electronic databases. The study assessed and compared survival outcomes including overall survival (OS), progression-free survival (PFS), second progression-free survival (PFS2), time to first subsequent treatment (TFST), time to second subsequent treatment (TSST), and chemotherapy-free interval (CFI). Additionally, safety outcomes were investigated, specifically focusing on grade 3–4 treatment-emergent adverse effects (TEAEs). The evaluation of OS and PFS was also conducted based on the BRCA and HRD (homologous recombination deficiency) statuses.

Results
Six randomized controlled trials were examined and the four PARPis (olaparib, niraparib, rucaparib and fuluzolparib) have been found to significantly increase the PFS in entire population as well as in subgroups of HRD and BRCAm (BRCA mutation). Only olaparib demonstrated a substantial improvement in OS compared to placebo in entire population (hazard ratio [HR] 0.73; 95% confidence interval [CI] 0.60–0.90), as well as in the subgroup of BRCAm. All analyzed PARPis had significant efficacy in prolonging PFS2, TFST, TSST and CFI. For safety concerns, PARPis could significantly increase incidence of TEAEs (grade3-4), while olaparib had least haematological TEAEs (grade3-4) events compared to other PARPis.

Conclusion
All included PARPis showed various degrees of benefit in survival outcomes and safety profile was acceptable for PSROC patients. Among them olaparib had the best performance in both efficacy and safety.
Assessment of smartphone-based active distraction in association with audioanalgesia for overcoming airotor-related anxiety in children: a randomized controlled trial
Authors: Bali Kritika , Ailawadi Radhika , Karuna Y. M. , Srikant N. , Rao Ashwin , Nayak P. Anupama , Thimmaiah Charisma 
Published: January 2025

Abstract

Background
Most children experience distress while visiting a dentist, above which the sound of the airotor and suction machine results in fear and difficulty in performing further procedures.

Methods
This was a randomized controlled parallel-group study of 40 children aged 6–13 years who required cavity preparation via the airotor. The children were randomly allocated to either Group 1 (Piano music app; active distraction combined with audio analgesia) or Group 2 (basic behavioural guidance alone). Self-reported dental anxiety was measured via a modified child dental anxiety scale, and behavior was assessed via Venham’s and FLACC (Faces Legs Activity Cry and Consolability) scales. The data obtained were subjected to appropriate statistical analysis.

Results
Self-reported dental anxiety was significantly lower in group 1 (p < 0.005). No significant difference between the groups was observed for the Venham and FLACC scores.

Conclusion
Compared with basic behavioural guidance alone, the use of active distraction with audio analgesia in the form of the piano music app significantly decreased the degree of dental anxiety caused by the use of the airotor. This also resulted in clinically better cooperation by the child during cavity preparation.

Trial Registration
Registered in the Clinical Trials Registry India (CTRI/2024/07/070160) dated 08/07/2024.
An updated systematic review with meta-analysis and meta-regression of the factors associated with human visceral leishmaniasis in the Americas
Authors: Duarte Anna Gabryela Sousa , Werneck Guilherme Loureiro , de Farias Lelis Sarah , Mendonça Thays Santos , Vasconcelos Daniela Dias , Gontijo Tiago Silveira , dos Santos Álisson Oliveira , Donato Lucas Edel , Belo Vinícius Silva 
Published: January 2025

Abstract

Background
Human visceral leishmaniasis (VL) is a systemic disease with high case-fatality rates and a widespread distribution. Continuous evaluation of the risk factors for VL is essential to ensure the effective implementation of prevention and control measures. The present study reviews the factors associated with VL in the Americas.

Methods
This systematic review updates a previous 2013 report by including cross-sectional, cohort and case-control studies published between July 2011 and April 2024. Associations between VL and risk factors were analyzed using random-effects meta-analysis, subgroup analysis, and meta-regression models. Studies were classified according to level of evidence using the GRADE approach and the evolution in the quality of investigations was assessed.

Results
Forty-six studies were included in the review and 21 variables were evaluated in the meta-analyses. Combination of all study types revealed that men had greater chances of VL than women, but the association was strong and significant only in case-control studies. Although higher chances of VL in children and in households with dogs or chickens/other fowl were identified in case-control studies, an inverse association was observed in cross-sectional and cohort studies. Higher chances of VL were associated with poor economic/living conditions, individuals living in domiciles with backyards or with seropositive dogs, and individuals with prior contact with infected household members/relatives/neighbors. The level of evidence for associations of VL with sex and age was classified as moderate whilst that for all other associations was either low or very low. The methodological quality of recent studies showed a positive progression but shortcomings were still evident regarding selection criteria and methods of data analysis.

Conclusion
While there is a higher incidence of symptomatic VL among men and children, the likelihood of infection is similar between the groups. There is insufficient evidence to support the claim that the presence of dogs or fowl at the domicile increases the chances of VL. However, socioeconomic and living conditions, as well as previous occurrence of human and canine VL, are influential factors. Future research should be conducted with greater statistical power and using molecular diagnostic techniques, preferably involving cohort studies in diverse Latin American countries.

Graphical Abstract
Analysis of functional and phylogenetic diversity of bat communities: insights from resource use in the Pantanal and Cerrado
Authors: de Oliveira Marcione B. , de Oliveira Luiz Flamarion B. , Bonvicino Cibele R. 
Published: January 2025

Abstract

Background
Assessing the structure of communities requires analysis of multiple dimensions of biological diversity. Such approaches provide a broader understanding of the ecological and historical factors involved in the formation and maintenance of communities. Metrics such as functional and phylogenetic diversity are crucial as they unveil how communities respond to environmental changes, providing a deeper understanding of their current state and resilience. This goes beyond species richness or community composition, enabling more profound insights into their present condition and resilience. Therefore, analysis in this sense allows accessing differences in the distribution of species, considering different landscape mosaics, and allowing strategic prioritization of conservation initiatives. In this sense, we investigated whether the composition of functional and phylogenetic groups of chiropteran species differs between the Pantanal and Cerrado biomes and various habitat types. We hypothesize that communities with greater conservation integrity are more diverse than communities that suffer anthropogenic influences.

Methods
The surveyed communities include two areas in the Pantanal and two in the Cerrado, with one conservation unit and one that suffers anthropic influence, for each biome. We assessed the composition of bat assemblages by examining functional richness (FRic), functional uniformity (FEve), functional divergence (FDiv), and functional dispersion (FDis). Metrics that reflect phylogenetic richness and divergence were also used, such as phylogenetic diversity (PD), mean pairwise distance (MPD), and mean nearest taxon distance (MNTD).

Results and discussion
Overall, conservation units sustain higher levels of functional and phylogenetic diversity compared to areas with anthropic influence. In the latter, species occupy fewer ecological niches, indicating that bats can persist in degraded environments, albeit the communities support only a portion of the functional groups.

Conclusion
Our results showed, through analyses across multiple dimensions of functional and phylogenetic diversity, that bat populations are impacted by environmental degradation and fragmentation. Communities in more conserved areas exhibited higher functional and phylogenetic richness, indicating a greater number of occupied niches. These findings highlight the importance of exploring measures of biological diversity and their spatial scales to advance our understanding of biodiversity dynamics and optimize conservation planning for both species and communities.
Impact of discontinuation of cephazolin prophylaxis on the incidence of postoperative adverse events in cataract surgery
Authors: Uchida Kazutaka , Takahama Keita , Higashi Kenshiro , Kusano Yuki , Matsumoto Koki , Nakagawa Yoshihiro , Oda Kazutaka 
Published: January 2025

Abstract

Background
Cataract surgeries are increasing annually, making appropriate medical management essential. The routine use of systemic antimicrobial agents for preventing surgical site infections lacks strong evidence and may increase the risk of drug-resistant bacteria and adverse events. This study examined the impact of discontinuing cefazolin (CEZ) administration during the perioperative period of cataract surgery on the incidence of postoperative adverse events and medical costs.

Methods
Inpatient cataract surgery patients were divided into two groups: the CEZ-use group (April 2021 to March 2022) and the non-CEZ-use group (April 2022 to March 2023). The primary endpoints were the incidence of adverse events and medical costs, while the secondary endpoint was the incidence of endophthalmitis.

Results
A total of 265 patients were in the CEZ group, and 316 were in the non-CEZ group. Six postoperative adverse events (2.3%, 95% confidence interval: 0.8–4.9) occurred in the CEZ group, with an estimated 230 patients (80–490 from the 95% confidence interval) expected to experience adverse events per 10,000 patients using CEZ. The non-CEZ group had no adverse events and reduced drug costs by approximately 46,000 yen. Insurance claim amounts were also reduced. No cases of early postoperative endophthalmitis were observed in either group.

Conclusions
Discontinuation of CEZ prophylaxis during the perioperative period of cataract surgery effectively reduced the risk of adverse events. Medical for the period after discontinuing CEZ did not increase.

Trial registration
Retrospectively registered.
Resilience vs. survival: same song, new melody?
Authors: Schötz Enrico 
Published: January 2025

Abstract
Does a firms resilience distinguish itself from its mere probability of survival in a way that justifies the expanding research? Answers to this question are found through a novel, systematic literature review focusing on the company’s life phase and its type of market exit. A comparison with current resilience literature shows that the concept of static resilience is closely related to survival probability considerations. It is suitable for examining indicators that act absorptive during disruptive phases of companies. The integration of dynamic resilience proves to be an achievement that sets the topic apart from pure corporate survival and develops it further. The close connection with innovative actions and differentiated results regarding its impact on survival probability jointly justifies the need for new measures of resilience for future empirical research.
Oral Cyclophosphamide for Patients With Metastatic Castration-Resistant Prostate Cancer in a Scenario of Limited Health Care Resources
Authors: Pineda Diana del Cisne , Polho Gabriel Berlingieri , Shinkado Yumi Ricucci , Contado Gustavo Alves , Crusoe Nathalia de Souza , Horita Vivian Naomi , Resende Joao Carlos , Silva Jamile Almeida , de Freitas Guilherme Fialho , Muniz David Queiroz , Suartz Caio V. , Ribeiro-Filho Leopoldo Alves , Hoff Paulo M. , Mota José Mauricio 
Published: January 2025

PURPOSE
Prior noncontemporary studies showed that oral cyclophosphamide is an active treatment of metastatic castration-resistant prostate cancer (mCRPC). However, cyclophosphamide is currently underutilized in routine clinical practice given the lack of survival benefit and the emergence of more effective treatments.

METHODS
We retrospectively reviewed our institutional database to identify patients with mCRPC treated with cyclophosphamide. Prostate-specific antigen decrease ≥50% from baseline (PSA50) response was determined as the proportion of patients achieving a prostate-specific antigen (PSA) decline ≥50% from baseline. Radiographic responses and progression were evaluated by Prostate Cancer Working Group 3. Survival estimates used the Kaplan-Meier method, and correlations were made with Chi-square test for categorical variables.

RESULTS
From January 2011 to January 2023, 341 patients with mCRPC received oral cyclophosphamide at a tertiary cancer center in São Paulo, Brazil. The most common regimen (95%) was 100 mg once daily 21 days on, 7 days off. At prostate cancer diagnosis, the median age was 64.4 years (IQR, 59.4-70.8), 61.9% had metastatic de novo disease, and 55.5% had Gleason ≥8. The median number of previous treatment lines was three (IQR, 2-4). Any PSA decline was observed in 33.4%, and 13.2% had a PSA50 response. Median response duration was 2.1 months (IQR, 1.4-3.8). Ten patients (3%) were treated for ≥1 year. PSA50 response was associated with no prior docetaxel use and Eastern Cooperative Oncology Group performance status 0 or 1.

CONCLUSION
Oral cyclophosphamide is a feasible treatment option for patients with mCRPC, particularly in a scenario of limited health care resources.