bluuebunny/crossref_metadata_2025_split huggingface dataset:
Argonaute protein assisted drug discovery for miRNA-181c-5p and target gene ATM translation repression: a computational approach
Authors: Tak Harshita , Anirudh Jivanage , Chattopadhyay Arpan , B Hemanth Naick 
Published: December 2023

Abstract

The miRNA binds to AGO's seed region, prompting the exploration of small molecules that can offset miRNA repression of target mRNA. This miRNA-181c-5p was found to be upregulated in the chronic traumatic encephalopathy, a prevalent neurodegenerative disease in contact sports and military personals. The research aimed to identify compounds that disrupt the AGO-assisted loop formation between miRNA-181c-5p and ATM, consequently repressing the translation of ATM. Target genes from commonly three databases (DIANA-microT-CDS, miRDB, RNA22 and TargetScan) were subjected to functional annotation and clustering analysis using DAVID bioinformatics tool. Haddock server were employed to make miRNA-181c-5p:ATM-AGO complex. A total of 2594 small molecules were screened using Glide XP based on their highest binding affinity towards the complex, through a three-phase docking approach. the top 5 compounds (DB00674 - Galantamine, DB00371 - Meprobamate, DB00694 - Daunorubicin, DB00837 - Progabide, and DB00851 - Dacarbazine) were further analysed for stability in the miRNA-181c-5p:ATM-AGO-ligand complex interaction using GROMACS (version 2023.2). Hence, these findings suggest that these molecules hold potential for facilitating AGO-assisted repression of ATM gene translation.
Genesis and evolution of deep K-rich confined brine in Mahai Basin, Qinghai-Tibet Plateau
Authors: Yang Fukang , Fan Qishun , Han Guang , Wang Shenglu , Liu Jiubo , Bai Hongkui 
Published: December 2023

Abstract
Mahai Basin (MH), situated in the northern Qaidam Basin (QB), occurred abundant K-rich brine resources. The study on origin of deep K-rich confined brine and variation in K-Mg elements correspond to evolution in MH light on the significance of the sustainable development and utilization of brine deposits. This study presents multiple isotopes (δ18O and δD, 87Sr/86Sr) and hydrochemical characteristics for river waters, surface brines, intercrystalline brines, confined brines, gravel-type brines and anticlinal brines in the MH. The results indicate that: (1) Compared with anticlinal brine, confined brine is characterized by high K, low Ca and Sr contents, and close to the supply path of water chemistry in Yuqia River (from Na-HCO3-SO4 field to Cl-SO4 field in Ca-SO4-HCO3 equivalent diagram), deciphering river water is the main water source for confined brine. (2) The δ18O-δD values of confine brine are spatially various in MH and fall on the right side of the local evaporation line in this study, which implies that confined brine underwent evaporation and concentration successively. (3) The 87Sr/86Sr ratios (0.7114298–0.7114522) of confined brine is between river water and Lenghu anticlinal water, and both river water and confine brine dominate in low Sr field, further verified that more recharge budget of river water. (4) Combining with the evolution of sedimentary facies (Dezongmahai lake area as an example), K and Mg concentrations in MH increased progressively from west to east and from south to north, demonstrating the enrichment of K and Mg aligns to the evolution of MH and northeastern part of this basin serving as the final depositional center.
Electrophysiological assessmentsof different working memory states for Alzheimer's mice
Authors: Wu Linyan , Huang Liang , Li Sinan , Zhang Wenlong , Zhou Ping , Liu Tian , Wang Jue 
Published: December 2023

Abstract
Reduced working memory is one of the important manifestations of senile dementia. Analyzing different brain regions in different states of working memory can help diagnose Alzheimer's disease and provide targets for intervention and treatment. In this study, we designed a Y-maze behavioral paradigm with voltage stimulus feedback and classified working memory states based on the selection of mice in continuous Y-maze behavior. We compared the differences in memory function between AD model mice and normal mice at the electrophysiological level. We found that: 1) the hippocampus and cingulate gyrus may play a more important role in working memory function than the frontal lobe, and the cingulate gyrus may become a new target for studying memory function; 2) Compared to the left brain region, the right brain region plays a more important role in the process of working memory; 3) Remembering the right events is more helpful for memorizing itself than remembering the incorrect events; 4) AD mice exhibit abnormalities in all three aspects mentioned above, especially abnormal brain connectivity during the correct memory process, leading to their inability to complete learning. Our research results provide an electrophysiological mechanism for the memory process, paving the way for further research into the mechanism of memory dysfunction in AD, and proposing potential intervention targets and strategies to improve memory dysfunction in AD.
Diversity and abundance of odonates (dragonflies and damselflies) and lepidopteran (butterflies) fauna of Kalyani Lake park, Nadia district, West Bengal, India
Authors: Dolai Sayak , Mallick Md. Abu Imran , Ghorai Narayan 
Published: December 2023

Abstract

Butterflies, dragonflies and damselflies are indeed important for ecosystem productivity, playing roles in pollination and insect control, contributing to a balanced and thriving ecosystem. Their presence showcases the health and abundance of the ecosystem. Biodiversity protection and conservation are indeed essential aspects of both national and international agendas, as they contribute significantly to the sustainable development of regions and countries. Biodiversity ensures the health and stability of ecosystems, provides ecosystem services crucial for human survival and well-being, and supports various industries such as agriculture, fisheries, and tourism. Lepidoptera and Odonata assemblage along with Kalyani Lake Park of Nadia district in West Bengal has been investigated. The dragonflies, damselflies and butterflies species were studied from August 2021 to September 2023. In this survey 25 species of dragonflies, 10 species of damselflies and 75 species of Butterflies were recorded. Among the odonate species, Libelluidae and Coenagrionidae were the dominant families with maximum number of species being 23 and 08 respectively. In the case of butterflies, Nymphalidae was the dominant family with 27 species while others have fewer representatives. Relative abundance and diversity indices were calculated for all species group. However, in the case of the urban forest area, the observed high anthropogenic disturbances create significant biotic pressure on the Kalyani Lake Park. Given the significance of understanding the insect diversity in this study area, a detailed list of recorded Odonata and Lepidoptera from the study would provide valuable insights into the specific species present, their distribution, and their potential interactions with the environment.
The Vulnerability of Communities to Climate Change-Induced Water Scarcity in Ethiopia and Kenya: A Systematic Review
Authors: Deresse Teshome 
Published: December 2023

Abstract
Climate change, as it is in many other parts of the world, is one of the many variables affecting the availability of water in Ethiopia and Kenya. Water scarcity problems are brought on by a lack of precipitation combined with a quick and persistent rise in temperature. The objective of this review paper is to examine how vulnerable communities in Ethiopia and Kenya are affected to water scarcity brought on by climate change, as well as how they can adapt. The analysis of 23 studies using systematic review methods identifies the characteristics of planned and spontaneous adaptations to water scarcity in Ethiopia and Kenya. Impacts of climate change were primarily caused by dry weather and uncertainty. According to empherical evidences, Ethiopia and Kenya are currently experiencing rising temperatures and fluctuating rainfall, and future forecasts point to an even worse situation. On a spatiotemporal basis, yet climate change varied, and in both countries, changes in the quantity and quality of water resources were among the effects that famed out. Population density, growing urbanization, and industrial are other factors that contribute to and exacerbate water scarcity in Ethiopia and Kenya. Nearly every economic sector in Ethiopia and Kenya has been impacted by the effects of climate change on water resources, including agriculture through unpredictable rainfall patterns, human health through water-borne illnesses during flooding, and trade through the destruction of road and telecommunication infrastructure. The degree of community susceptibility varies by nation, area, and geographic capabilities, with women and children being particularly vulnerable to climate change-related water scarcity that requires adaptation or mitigation. Building Ethiopia's and Kenya's resilience to the impacts of climate change on water resources necessitates a holistic strategy that integrates systems thinking and risk management techniques. The prevention of a water shortage depends on prompt action using science, technology, and innovation, rules governing water audit and management, and involvement of the private, public, and international sectors.
Effects of Excess Atmospheric CO2 on Calcium Carbonate Producers along the Red Sea Coast of Yemen: Its Risk and Socio-economic Impacts.
Authors: Rushdi Ahmed 
Published: December 2023

Abstract
The formation of calcite and aragonite, integral components of marine organisms’ skeletons, is contingent on the degree of saturation (W) of seawater with respect to carbonate minerals. The decrease in W, driven by an excess of atmospheric carbon dioxide, poses challenges for calcifying organisms in their ability to create and maintain their skeletal structures and shells. As a result, we conducted a collection of surface seawater samples from various locations along the Red Sea coast of Yemen to address three key objectives: (1) ascertain the current W values for calcite and aragonite, (2) project alterations in these values attributable to seawater pH reduction (acidification) over the next 50 and 200 years, and (3) assess potential ecological consequences and risks associated with these impeding changes. During both winter and summer, we conducted measurements of various oceanographic parameters, including temperatures (ToC), salinities (S), pH values, and total alkalinities (TA). In winter season, these parameters were ToC = 26.4±0.5oC, S = 36.9±0.5, pH = 8.16±0.3 and TA = 2.409±0.104 meq/Kg, whereas in summer ToC = 34.6±0.6oC, S = 38.5±0.2, pH = 8.11±0.12 and TA = 2.428±0.036 meq/Kg. These measured parameters served as crucial inputs for the assessment of carbonate chemistry, including the determination of seawater’s W values with respect to both calcite and aragonite. The findings indicated that surface seawater was supersaturated with respect to both calcite and aragonite. The percent degree of saturation (%W) for calcite was 553±89% in winter and 607±77% in summer, while for aragonite was 367±58% in winter and 415±53% in summer. Over the course of the next five decades, the surface seawater %W with respect to calcite is projected to decrease approximately 464±111% during winter months and 499±78% during summer. At the same time, it is expected to decline to around 251±60% in winter and 341±53% in summer for aragonite. In the next two centuries, these percentages are anticipated to further decrease to 249±57% in winter and 281±48% in summer for calcite, and to 135±31% in winter and 192±33% in summer for aragonite. Acidification of seawater will have serious environmental consequences on the marine and coastal habitats of the Red Sea of Yemen and the entire region. Further studies are warranted to monitor and investigate the occurrence, distribution, mineralogy of corals, and the effects of physical and chemical parameter variations on their growth in the region.
A pair of Chinese Shang oracle graphs Niu and Yang for certain livestock originate from the Neolithic Fertile Crescent
Authors: Liu Zhihua 
Published: December 2023

Abstract

Utilizing the multiple evidence of genetics, archaeology, iconography, graphemics and philology, this paper discovers two foreign elements Niu and Yang from the Fertile Crescent, in the Shang oracle inscriptions. This discovery provides a clue to investigate the relations of several pictograph type writing systems of the Bronze Age old world. The connection of the Shang graph pair Niu and Yang with the Halaf culture motif pair bucrania and mouflons is disclosed by the shared contents of their meaning: taurine cattle and sheep/goats from the Fertile Crescent. The second prototype of the Halaf motif pair, the back view of the whole body is distinguished from the head view by comparing the motifs with animal images and according to their placement in the evolution. Owing to the same forms, the same degree of abstraction, and the same diagnostic feature, a pair of huge and curved horns, the Shang graph pair falls in the clusters of those abstract variants of the Halaf motif pair, which coincide with that the Shang graph pair stay outside the category of all the other four-legged animals’ Shang oracle graphs, not only because of the different view types, but also the more abstract forms implying their more ancient times.
Dialogue and defamiliarization
Authors: Tengberg Michael , Johansson Maritha , Sønneland Margrethe 
Published: December 2023

To lead discussions about complex literary texts in a classroom of teenagers is no doubt a challenging task for many teachers. It is therefore meaningful to explore how teachers’ management of literature discussions can be supported and improved. Prior research indicates a positive relationship between certain modes of discussion and increased literary awareness. Yet observational studies underscore that open-ended, probing discussions about literature are scarce in today’s classrooms.
This article elaborates the theoretical framing of an intervention designed to improve the quality of teacher-led discussions about complex literary texts. We argue that dialogic theory, appropriate for highlighting the processes of classroom interaction, needs to be supplemented by theory that offers an explanation for the role of the literary text and its impact on both readers and their interaction processes. For this purpose, we examine the conceptual matching between theory of dialogic teaching, drawing on Bakhtin’s idea of meaning making as inherently dialogic, and theories of literary reception, specifically Shklovsky’s concept defamiliarization and recent didactical analysis of Derrida’s concept undecidability. The intention of the paper is to suggest a theoretical framing of the intervention, one that allows for both analysis of the aesthetic processes of reading and talking about literature, and specific guidance of teachers’ management of those discussions.
Administrative Procedure in the Field of Public Health
Authors: Zyma Oleksandr 
Published: December 2023

The relevance of the proposed study is due to the parallel significant update of medical legislation and the entry into force of the Law of Ukraine "On Administrative Procedure". The purpose of the proposed research is to assess the quality of legal regulation of certain administrative proceedings in the field of public health, which has undergone significant changes in the last months of 2023. The results of the study, on the one hand, will help to identify shortcomings and legal conflicts that have formed, and on the other hand, to develop and suggest ways to overcome some of them. The research methodology consists of the following methods of scientific cognition: dialectical, theoretical-prognostic, comparative-legal, system-structural, formal-logical, analysis, legal modeling, and others. In the course of the work, the importance of proper legal regulation and effective public administration in the field of public health is emphasized. The place of administrative bodies in the system has been establishedsubjects of relations in the field of public health. A classification of measures used by specialized administrative bodies in their activities has been proposed. The significance of administrative proceedings and administrative acts used in the process of public administration of public health is disclosed and the most significant among them are highlighted: control and supervision, on the application of termination measures, registration. The essence of each of these proceedings has been investigated and the shortcomings of their regulation have been identified, due to the inconsistency of the norms of the Laws of Ukraine "On the Public Health System" and "On the Administrative Procedure". Significant shortcomings in the legal regulation of administrative proceedings on the application of temporary measures to stop violations of the requirements of sanitary legislation are noted and possible problems in its application are indicated. Attention is also focused on the shortcomings of the terminology used in the Law "On the Public Health System". The results of the study can contribute to the improvement of legislation in the field of public health, as well as to improve the quality of formation law enforcement practice of administrative bodies that are subjects of the public health system.
Developing a Machine Learning Algorithm to Predict the Probability of Medical Staff Work Mode Using Human-Smartphone Interaction Patterns: Algorithm Development and Validation Study
Authors: Chen Hung-Hsun , Lu Henry Horng-Shing , Weng Wei-Hung , Lin Yu-Hsuan 
Published: December 2023

Background
Traditional methods for investigating work hours rely on an employee’s physical presence at the worksite. However, accurately identifying break times at the worksite and distinguishing remote work outside the worksite poses challenges in work hour estimations. Machine learning has the potential to differentiate between human-smartphone interactions at work and off work.

Objective
In this study, we aimed to develop a novel approach called “probability in work mode,” which leverages human-smartphone interaction patterns and corresponding GPS location data to estimate work hours.

Methods
To capture human-smartphone interactions and GPS locations, we used the “Staff Hours” app, developed by our team, to passively and continuously record participants’ screen events, including timestamps of notifications, screen on or off occurrences, and app usage patterns. Extreme gradient boosted trees were used to transform these interaction patterns into a probability, while 1-dimensional convolutional neural networks generated successive probabilities based on previous sequence probabilities. The resulting probability in work mode allowed us to discern periods of office work, off-work, breaks at the worksite, and remote work.

Results
Our study included 121 participants, contributing to a total of 5503 person-days (person-days represent the cumulative number of days across all participants on which data were collected and analyzed). The developed machine learning model exhibited an average prediction performance, measured by the area under the receiver operating characteristic curve, of 0.915 (SD 0.064). Work hours estimated using the probability in work mode (higher than 0.5) were significantly longer (mean 11.2, SD 2.8 hours per day) than the GPS-defined counterparts (mean 10.2, SD 2.3 hours per day; P<.001). This discrepancy was attributed to the higher remote work time of 111.6 (SD 106.4) minutes compared to the break time of 54.7 (SD 74.5) minutes.

Conclusions
Our novel approach, the probability in work mode, harnessed human-smartphone interaction patterns and machine learning models to enhance the precision and accuracy of work hour investigation. By integrating human-smartphone interactions and GPS data, our method provides valuable insights into work patterns, including remote work and breaks, offering potential applications in optimizing work productivity and well-being.
Matrakçı Nasuh’un Beyân-ı Menâzil-i Sefer-i Irakeyn Adlı Eserinde Konya Kalesi
Authors: ÖZKAN Ela , ŞİMŞİR Zekeriya 
Published: December 2023

Minyatürler geçmişe ışık tutan, tarihi belgelere görsel nitelik kazandıran en önemli kaynaklardan biridir. Topografik konulu minyatürler ise Osmanlı dönemi minyatür sanatının önemli bir kısmını oluşturmakta olup konu ile ilgili en önemli minyatürlü yazmalardan biri de hiç şüphesiz Matrakçı Nasuh’un Beyân-ı Menâzil-i Sefer-i Irakeyn isimli eseridir. Matrakçı Nasuh, bu eserinde Kanuni Sultan Süleyman’ın İran seferinde İstanbul’dan hareket ederek Tebriz’e kadar ordunun geçtiği bütün menzillerin fizikî durumunu ve topoğrafyasını tasvir etmiştir. Konya kenti de bu kapsamda minyatürü yapılan menzillerden biridir.
Bu çalışmayla Matrakçı Nasuh’un Konya minyatürünü resmederken konuya yaklaşımı, öncelik verilen ögelerin saptanması, kalenin form, renk, üslup bağlamında tanımlanması ve aynı zamanda sanatçının üslubunun mimariye nasıl yansıdığının tespit edilmesi amaçlanmıştır. Ayrıca minyatür ayrıntılı olarak tanıtılıp çalışma sonucunda minyatürde yer alan kale ile eldeki bilgiler ışığında kalenin özgün durumu arasında bağlantılar kurularak araştırmada varılan sonuçlar aktarılmaya çalışılacaktır.
Exploring Genetic Variability, Correlation and Path Analysis in Fenugreek (Trigonella foenum-graecum L.) for Crop Improvement
Authors: Shivraj  , Kumar Pramod , Kumar Rajneesh , Chouhan Shambhu , Tutlani Aman 
Published: December 2023

The present investigation has been carried out at Agricultural Research Station, Mandor, Jodhpur during month of Rabi season (October, 2016–April, 2017) to evaluate 35 genotypes of fenugreek to assess extent of genetic variability, heritability, genetic advance with correlation and path coefficient for yield and its contributing characters. The material was planted in Randomized Block Design with three replications and observations were recorded on individual plant basis. Analysis of variance recorded significant between genotypes for the characters studies. The genotypic and phenotypic coefficient of variation was higher for seed yield per plant (g). High heritability (broad sense) coupled with high genetic advance as percentage of mean was observed for branches per plant, no. of pods per plant, pod length (cm), seeds per pod, test weight (g) and seed yield per plant (g). The correlation analysis at genotypic and phenotypic level, seed yield per plant was positively significant correlated with branches per plant, number of pods per plant, test weight, harvest index, days to 50% flowering, pod length and seeds per pod, but except days to maturity at phenotype level which was correlated with negative significance. Path coefficient analysis suggested that the highest positive direct effect on grain yield per plant was exerted by harvest index (%) followed by seeds per pod, test weight, days to 50% flowering, plant height and branches per plant. Number of pods per plant, pod length (cm) and days to maturity contributed considerable negative direct effect on grain yield per plant.
Analisis Proses Proses Penerbitan Majalah Sekolah Swara Puspita Bangsa di Perpustakaan SMA N 1 Pundong Bantul Yogyakarta
Authors: Prahesti Maridha 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis proses penerbitan Majalah Swara Puspita Bangsa di Perpustakaan SMA N 1 Pundong Bantul Yogyakarta. Dengan menggunakan metode deskriptif kualitatif, peneliti mengumpulkan data dengan cara observasi, dokumentasi dan wawancara. Studi ini menemukan proses publikasi terdiri dari tujuh tahap, yaitu: 1) Strukturisasi, 2) Penetapan tema, 3) Rubrikasi, 4) Produksi, 5) Peluncuran, 6) Distribusi, dan 7) Evaluasi keseluruhan proses. Kajian ini juga mengungkap dua permasalahan dalam penerbitan Majalah Swara Puspita Bangsa, yaitu sulitnya pengumpulan naskah yang berdampak pada pergeseran terbitan isu terkini. Selain itu, mahasiswa yang mengelola majalah juga memiliki keterbatasan dana untuk menanggung biaya operasionalnya. Kata Kunci : Serial, Majalah sekolah, publikasi, SMA N 1 Pundong