bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Sitting Time With All-Cause and Cardiovascular Mortality: How Does Frailty Modify This Association?
Authors: Diaz-Toro Felipe , Nazzal Nazal Carolina , Nazar Gabriela , Diaz-Martinez Ximena , Concha-Cisternas Yeny , Celis-Morales Carlos , Petermann-Rocha Fanny 
Published: December 2023

To investigate how frailty modifies the association of sitting time with all-cause and cardiovascular mortality in Chilean adults. This prospective study included 2,604 participants aged ≥35 from the Chilean National Health Survey 2009–2010. Sitting time was self-reported, while frailty was assessed using a 36-item Frailty Index. Sitting time was categorized as low, medium, and high. Cox proportional hazard models were used to estimate the risk of mortality stratified for the sitting time categories. Over a median follow-up of 8.9 years, 311 participants died, 28% of them due to cardiovascular events. Frail people with prolonged sitting time were at higher risk of all-cause and cardiovascular mortality (hazard ratio 3.13; 95% confidence interval [2.06, 4.71] and hazard ratio 2.41; 95% confidence interval [1.50, 3.64], respectively). The observed risk was higher in women than men. Public health and individual strategies should be implemented to decrease sitting time across the population, with special attention on frail people.
Association Between Typologies of Sedentary Behavior and Muscle Strength, Gait Speed, and Balance in Community-Dwelling Older Adults
Authors: Cândido Letícia Martins , de Avelar Núbia Carelli Pereira , D’Orsi Eleonora , Lacerda Ana Cristina Rodrigues , Mendonça Vanessa Amaral , Tringali Gabriella , Sartorio Alessandro , Danielewicz Ana Lúcia 
Published: December 2023

Knowledge of how the different types of sedentary behaviors (SB) are associated with functional limitations can guide professionals who work with older adults on better recommendations about the amount of daily time that should be encouraged in each type of SB. The objective was to estimate the associations between two SB typologies (SB television [TV] and SB computer/internet) and the presence of handgrip strength, lower limb strength, gait speed, and balance limitations in Brazilian community-dwelling older adults. This is a cross-sectional study with 1,298 community-dwelling older adults (≥60 years). SB was assessed by self-reporting daily time spent watching TV or using computer/internet (categorized into <2, 3–4, and ≥5 hr/day). Outcomes were handgrip strength, lower limb strength, gait speed, and balance limitations considering referenced cutoff points. Older adults in SB TV ≥5 hr/day had 1.75 (95% confidence interval [CI] [1.07, 2.86]) and 1.88 (95% CI [1.02, 3.46]) times more chances of handgrip strength and gait speed limitations, respectively. On the other hand, those who spent 3–4 and ≥5 hr/day in SB computer/internet had 0.45 (95% CI [0.20, 0.99]) and 0.37 (95% CI [0.15, 0.93]) had less chances of lower limb strength and balance limitations, respectively. In conclusion, functional limitations would be associated differently depending on the type of SB in the older adults sampled.
U-Pb geochronology and petrography of Neoproterozoic to early Cambrian volcanic rocks in basement crustal terranes beneath the deep-water Gulf of Mexico
Authors: Mallis Jillian D. , Zemlicka George , Antonijevic Sanja Knezevic , Lapen Thomas J. , Costin Gelu , Campbell Tania 
Published: December 2023

AbstractThough the Gulf of Mexico has been studied for more than a century, the lithology, age, and origin of the basement crustal terranes remain poorly understood. New U-Pb zircon ages of a volcanic sample in the DeSoto Canyon 535 #1 Raptor well were obtained by in situ laser-ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) and resulted in a crystallization age of 509 ± 23 Ma, indicating the crustal terrane beneath the northeastern Gulf of Mexico is likely of peri-Gondwanan affinity. This basement may be associated with the felsic volcanism related to Neoproterozoic to Cambrian subduction along the supercontinent’s western margin. This subduction-related volcanism likely represents the last pulses of magmatic activity before the west coast of Gondwana transitioned into a passive margin ca. 500 Ma. The data presented here for the DeSoto Canyon 535 #1 Raptor trachyte represent the oldest radiometrically dated evidence of volcanism in the present-day deep-water Gulf of Mexico.
Interplay of sociodemographic factors and antenatal care attendance with free maternal care policy: a case study of Ghana
Authors: Boadi Caleb , Osei Bonsu Emmanuel , Okeke Sylvester Reuben , Boadu Elijah Frimpong , Addo Isaac Yeboah 
Published: December 2023

IntroductionThe Free Maternal Care Policy (FMCP) was introduced in Ghana around 2008 as part of the government’s efforts to improve maternal and child health outcomes in the country. The policy was aimed at increasing access to antenatal care (ANC) services and reducing financial barriers to antenatal healthcare utilisation. Despite the expected success of the FMCP, there is limited evidence regarding its impact on the frequency of ANC visits across different sociodemographic groups of women in Ghana. This study examined associations between sociodemographic and health-related factors and the frequency of ANC attendance while considering the implementation period of the FMCP in Ghana as a fundamental reference point.MethodsThis quantitative study used Ghana’s Demographic and Health Survey datasets on pregnant women’s ANC visits for 2003, 2008 and 2014 (N=15 408). Logistic regression and descriptive analyses were conducted using Stata/SE V.14.ResultsFindings showed a slight fluctuation in the level of ANC visits before and after the introduction of the FMCP in Ghana. This fluctuation may indicate that ANC service cost as a barrier to ANC visits may not be the only factor affecting ANC utilisation among pregnant women in Ghana. Our results showed that women’s lack of autonomy to make health-related decisions affected their ANC service utilisation, particularly in 2008. In addition, we found that educational attainment, being wealthy and urban residency were also significantly associated with ANC service utilisation among pregnant women in Ghana, particularly, in 2003. Women’s anaemic levels were significantly associated with their likelihood of attending ANC services in 2003 and 2014.ConclusionsOur findings suggest that the FMCP may have had a discernible effect on the utilisation of ANC services in Ghana. However, other significant confounding factors may be influencing the ongoing use of ANC services in this setting.
Exploration history of the igneous reservoirs of the Rio Grande Valley (Mendoza), Neuquén Basin (Argentina)
Authors: Rebori Luis Osvaldo , Barrionuevo Marcelo Fabio , Palma Joaquin Octavio , Medialdea Adrian 
Published: December 2023

Abstract
Oil seeps related to igneous rocks in the Neuquén Basin have been known since pre-Hispanic times (sixteenth century) and have been explored in the southern Mendoza province since the late nineteenth century. In the 1980s, YPF (Yacimientos Petrolíferos Fiscales) began the exploration of igneous rocks as hydrocarbon reservoirs in the Río Grande Valley area. The possible productivity of these ‘unconventional’ reservoirs was recognized by studying outcrops and well data of sills and dykes emplaced in different formations of the fold and thrust belt of the northern Neuquén Basin. Mud-logging control and evaluations with drill stem tests (DST) were decisive to define these reservoirs as prospective. From petrographical reports on samples from outcrops and cores, six lithological types could be distinguished in the igneous units of this region. Recent works confirm that this volcanism belongs to two predominant cycles: from the late Oligocene to the Miocene (‘Molle’) and from the Middle to upper Miocene (‘Huincán’). Although in igneous reservoirs it is difficult to forecast the estimated ultimate recovery (EUR), sills that crosscut the source rocks of the Vaca Muerta and Agrio formations demonstrate surprisingly high production rates, although the number of wells for the complete development is always difficult to establish.
Trends in Atmospheric Heat Transport Since 1980
Authors: Cox Tyler , Donohoe Aaron , Armour Kyle C. , Frierson Dargan M. W. , Roe Gerard H. 
Published: December 2023

Abstract
We investigate the linear trends in meridional atmospheric heat transport (AHT) since 1980 in atmospheric reanalysis datasets, coupled climate models, and atmosphere-only climate models forced with historical sea surface temperatures. Trends in AHT are decomposed into contributions from three components of circulation: (i) transient eddies, (ii) stationary eddies, and (iii) the mean meridional circulation. All reanalyses and models agree on the pattern of AHT trends in the Southern Ocean, providing confidence in the trends in this region. There are robust increases in transient-eddy AHT magnitude in the Southern Ocean in the reanalyses, which are well replicated by the atmosphere-only models, while coupled models show smaller magnitude trends. This suggests that the pattern of sea surface temperature trends contributes to the transient-eddy AHT trends in this region. In the tropics, we find large differences between mean-meridional circulation AHT trends in models and the reanalyses, which we connect to discrepancies in tropical precipitation trends. In the Northern Hemisphere, we find less evidence of large-scale trends and more uncertainty, but note several regions with mismatches between models and the reanalyses that have dynamical explanations. Throughout this work we find strong compensation between the different components of AHT, most notably in the Southern Ocean where transient-eddy AHT trends are well compensated by trends in the mean-meridional circulation AHT, resulting in relatively small total AHT trends. This highlights the importance of considering AHT changes holistically, rather than each AHT component individually.
Chronic Absenteeism and Its Impact on the Learning Outcomes of Primary Grade Students in India
Authors: Jain Charu , Jain Ruchi 
Published: December 2023

This article addresses one of the most critical yet overlooked problems of the excessive absence of students in primary grades in India. Considering the intuitive link between students’ attendance and achievements, this article empirically investigates the incidences and causes of chronic absenteeism while examining the variations in the attainment of foundational skills of primary students. Using data from the India Human Development Survey, round II, the authors find a continuous decline in the attainment of foundational skills among students as the absenteeism rate increases from ‘normal’ to ‘chronic’, clearly indicating that attendance works! Further, the logistic regression model shows that poor health conditions of a child, larger school distance, extra school working hours, teaching factors and harsh punishments are among the major contributing factors leading to chronic absence among students. Early attention and strict policy interventions are required due to their direct implications on the cognitive growth of young minds and the quality and productivity of the overall school education. JEL Codes: I21, I24, I28
Urban Exclusion: Rethinking Social Protection in the Wake of the Pandemic in India
Authors: Choudhuri Pallavi , Pramanik Santanu , Desai Sonalde 
Published: December 2023

The COVID-19 pandemic, and the consequent nationwide lockdown in India that began on 25 March 2020, caused a major disruption in the labour market, leading to the widespread loss of livelihoods and food insecurity. The findings from a telephonic survey of a representative sample of more than 3,000 households in the National Capital Region also reveal a dramatic loss in earning capacity. The place of residence and occupation mediated the impact of the lockdown, with greater vulnerabilities witnessed amongst those engaged in informal employment, especially in urban areas. The government rolled out a series of welfare measures in response to the widespread economic distress, with the provision of free foodgrains and cash transfers aimed at rehabilitating those who were the most affected. While the use of prior social registries enabled quick disbursement, our analysis shows that few households received both foodgrains and cash transfers, particularly in urban areas. Urban residents were also eight percentage points less likely to receive cash transfers than their rural counterparts. JEL Codes: I38, J21, O17
Perspectives of Community Nurses on Treatment Engagement of Persons with Severe Mental Illnesses (PwSMI): A Qualitative Study from South India
Authors: Somanathan Revathi , Gandhi Sailaxmi , Sivakumar Thanapal , Manjunatha Narayana , Jayarajan Deepak , Thirthalli Jagadisha , Parthasarathy Rajani 
Published: December 2023

Background: There is increasing evidence of the need for treatment engagement between Persons with Severe Mental Illnesses (PwSMIs) and Mental Health Professionals (MHPs). This therapeutic process involves collaborative work between patients and MHPs, which improves the condition. Community nurses are uniquely positioned to facilitate this process as they act as the focal point of interaction between patients and the health system. Methods: This qualitative study explored the community nurses’ experiences in treatment engagement with PwSMI through eight group interviews of 35 community nurses from District Mental Health Programs (DMHPs) across Karnataka (South India) from February 2020 to March 2020. The audio recordings of the interviews were transcribed and coded to arrive at themes and subthemes. Results: The major themes identified were factors influencing treatment engagement, strategies to tackle treatment nonengagement, and challenges in dealing with nonengagement. The reasons for nonengagement were lack of insight and lack of knowledge of sociocultural, logistic, and treatment-related factors. The DMHP teams contacted patients through phone calls, home visits, and liaisons with health workers and intervened with them through education and depot injections. The major challenges were difficulty conducting home visits, distances, the unavailability of medications, and the need for adequate infrastructure and human resources. Conclusion: Community nurses address a few factors of nonengagement, such as insight, sociocultural factors, and treatment-related factors. Addressing the systemic challenges and adequate training of nurses in intervening in the dropped-out PwSMIs would help to reduce the treatment gap.
The anterior saphenous vein. Part 4. Clinical and technical considerations in treatment. Endorsed by the American Vein and Lymphatic Society, the American Venous Forum, and the International Union of Phlebology
Authors: Boyle Edward M , Drgastin Rachel , Labropoulos Nicos , Caggiati Alberto , Gasparis Antonios , Doganci Suat , Meissner Mark 
Published: December 2023

Background The decision to treat a refluxing anterior saphenous vein (ASV) should be a clinical decision based on the assessment on the ASV’s contribution to patient’s signs and symptoms. Once the decision to treat has been made, there are anatomic, clinical, and technical considerations in treatment planning. Methods Clinical scenarios were discussed by a panel of experts and common anatomic, clinical, and technical considerations were identified. Results There are unique clinical considerations such as whether both the great saphenous vein (GSV) and ASV should be concomitantly treated, if a normal ASV should be treated when treating a refluxing GSV and when and how to treat the associated tributary varicose tributaries. Being aware of the anatomic, clinical, and technical considerations allows development of a treatment plan that optimizes long-term outcomes in patients with ASV reflux. Conclusion Ultimately the treatment plan should be tailored to address these types of variables in a patient-centered discussion.
UTE T2* cartilage mapping in the hip: a pilot study assessing cartilage in patients with femoroacetabular impingement
Authors: Wong Tony T , Igbinoba Zenas , Tokaria Rumana , Quarterman Patrick , Fung Maggie , Jaramillo Diego , Jambawalikar Sachin R 
Published: December 2023

Background UTE T2* cartilage mapping use in patients undergoing femoroacetabular impingement (FAI) has been lacking but may allow the detection of early cartilage damage. Purpose To assess the reproducibility of UTE T2* cartilage mapping and determine the difference in UTE T2* values between FAI and asymptomatic patients and to evaluate the correlation between UTE T2* values and patient-reported symptoms. Material and Methods Prospective evaluation of both hips (7 FAI and 7 asymptomatic patients). Bilateral hip 3-T MRI scans with UTE T2* cartilage maps were acquired. A second MRI scan was acquired 1–9 months later. Cartilage was segmented into anterosuperior, superior, and posterosuperior regions. Assessment was made of UTE T2* reproducibility (ICC). Mean UTE T2* values in patients were compared ( t-tests) and correlation was made with patient-reported outcomes (Spearman's). Results ICCs of mean UTE T2* were as follows: acetabular, 0.82 (95% CI=0.50–0.95); femoral, 0.76 (95% CI=0.35–0.92). Significant strong correlation was found between mean acetabular UTE T2* values and iHOT12 (ρ = −0.63) and moderate correlation with mHHS (ρ = −0.57). There was no difference in mean UTE T2* values between affected vs. non-affected FAI hips. FAI-affected hips had significantly higher values in acetabulum vs. asymptomatic patients (13.47 vs. 12.55 ms). There was no difference in mean femoral cartilage values between the FAI-affected hips vs. asymptomatic patients. The posterosuperior femoral region had a higher mean value in non-affected FAI hips vs. asymptomatic patients (12.60 vs. 11.53 ms). Conclusion UTE T2* cartilage mapping had excellent reproducibility. Affected FAI hips had higher mean acetabular UTE T2* values than asymptomatic patients. Severity of patient-reported symptoms correlates with UTE T2* acetabular cartilage values.
Cancer susceptibility 18 positively regulates NUAK Family Kinase 1 expression to promote migration and invasion via sponging of miR-5586-5p in cervical cancer cells
Authors: Wang Jingrong , Zhang Bocheng , Gong Sha , Liu Ying , Yi Liang , Long Ying 
Published: December 2023

Introduction Cervical squamous cell carcinoma (CESC) is the most common gynecological malignancy worldwide. Although the cancer susceptibility 18 (CASC18) gene was involved in the regulation of cancer biology, its specific role in CESC is not well characterized. Methods CASC18-related axis was predicted by bioinformatic analyses, and the competing endogenous RNA (ceRNA) interaction was further validated using quantitative real-time PCR, western blotting, RNA pulldown, and luciferase reporter assays. Transwell and wound healing assays were performed to verify the effect of CASC18 on SiHa and HeLa cell motility. Results We found that CASC18 was upregulated in CESC tissues. Moreover, interference with CASC18 attenuated NUAK1-mediated epithelial-mesenchymal transition (EMT) and thus suppressed cancer cell motility. Furthermore, the effects of CASC18 knockdown on CESC cells were partly rescued by transfection with the miR-5586-5p inhibitor. Additionally, our findings indicated that CASC18 acts as a ceRNA to enhance NUAK1 expression by sponging miR-5586-5p. Conclusion Our study showed a novel CASC18/miR-5586-5p/ NUAK1 ceRNA axis that could regulate cell invasion and migration by modulating EMT in CESC. These findings suggest that CASC18 may potentially serve as a novel therapeutic target in CESC treatment.
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice
Authors: Tang Leilei , Mei Xuan , Ye Mengling , Liu Yang , Huang Yujie , Yu Jiawen , Zhang Lingdi , Zhuge Sheng , Jiang Guojun , Zhu Jianjun 
Published: December 2023

Objectives: Sclareol (SCL) is a natural diterpene with anti-inflammation and antioxidant properties. This study aimed to assess the hepatoprotective effects of SCL in diabetic mice. Methods: SCL (10 mg/kg) was administered intragastrically to C57BL/6 mice with streptozotocin-induced diabetes daily for 5 weeks to evaluate its beneficial effects in liver injury. Body and liver weight and blood glucose levels were measured. Liver histopathology, fibrosis, and lipid accumulation were evaluated using hematoxylin and eosin, Masson's trichrome, and Oil Red O staining, respectively. Serum hepatic enzyme and lipid levels were measured using an automatic biochemical analyzer. Hepatocellular apoptosis was measured using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. Oxidative stress markers and reactive oxygen species (ROS) were measured using appropriate assay kits. The effects of sclareol on inflammation and lipid metabolism was evaluated by enzyme-linked immunosorbent assay (ELISA), immunohistochemical analysis, and Western blot assays. Results: SCL significantly decreased serum liver enzymes and lipids levels, and alleviated adipogenesis and fibrosis. Moreover, the protein levels of acetyl-CoA carboxylase and sterol response element-binding protein 1 were downregulated, whereas the expression of carnitine palmitoyl transferase 1 was upregulated. SCL increased the antioxidant activity, and decreased ROS levels. SCL alleviated hepatic mitochondrial damage. Furthermore, SCL inhibited Kupffer cell infiltration and reduced serum inflammatory cytokine levels. SCL significantly downregulated the protein expression of nuclear factor-kappa B (NF-κB) P65, NOD-like receptor protein 3 (NLRP3), caspase 1, and interleukin-1β. Conclusions: Our findings suggest that SCL improves diabetes-induced liver injury by alleviating the NF-κB/NLRP3-mediated inflammation and lipid metabolism disorder.
Persistent and Changing Food Insecurity Among Students at a Midwestern University is Associated With Behavioral and Mental Health Outcomes
Authors: Slotnick Melissa J. , Ansari Saba , Parnarouskis Lindsey , Gearhardt Ashley N. , Wolfson Julia A. , Leung Cindy W. 
Published: December 2023

Purpose To assess associations between persistent and changing food insecurity and behavioral and mental health outcomes in college students. Design Online surveys conducted November 2018 and March 2019 (freshman year), and March 2020 (sophomore year) were used to assess food insecurity, which was then used to create 4 food security transitions: persistent food insecurity, emergent food insecurity, emergent food security, and persistent food security. Setting Large Midwestern university. Sample 593 students completing all 3 surveys. Measures Dietary intake and behavioral and mental health outcomes (eating disorders, anxiety, depression, sleep quality) were assessed using validated instruments. Analysis Associations between food security transitions and dietary intake, behavioral, and mental health outcomes were examined using generalized linear models. Results Compared to persistent food security, emergent and persistent food insecurity was associated with lower (7% and 13% respectively) intake of fruits and vegetables combined; persistent food insecurity was associated with 17% lower intake of fruits, 6% lower intake of fiber and 10% higher intake of added sugar from beverages. Compared to persistent food secure students, eating disorder symptom risk was higher for emergent food insecure (OR = 7.61, 95% CI: 3.32, 17.48), and persistent food insecure (OR = 6.60, 95% CI: 2.60, 16.72) students; emergent (OR = 2.05, 95% CI: 1.14, 3.71) and persistent (OR = 2.55, 95% CI: 1.34, 4.87) food insecure students had higher odds of poor sleep quality, and persistent food insecure, emergent food insecure, and emergent food secure students had higher odds of anxiety and depression (OR range 2.35-2.85). Conclusion Food security transitions were associated with aspects of low diet quality and poorer behavioral and mental health outcomes among college students.