bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of Telepsychiatry Assessments Using the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV for Children With Neurodevelopmental Disorders and Their Caregivers: Randomized Feasibility Study
Authors: Kurokawa Shunya , Nomura Kensuke , Hosogane Nana , Nagasawa Takashi , Kawade Yuko , Matsumoto Yu , Morinaga Shuichi , Kaise Yuriko , Higuchi Ayana , Goto Akiko , Inada Naoko , Kodaira Masaki , Kishimoto Taishiro 
Published: February 2024

Background
Given the global shortage of child psychiatrists and barriers to specialized care, remote assessment is a promising alternative for diagnosing and managing attention-deficit/hyperactivity disorder (ADHD). However, only a few studies have validated the accuracy and acceptability of these remote methods.

Objective
This study aimed to test the agreement between remote and face-to-face assessments.

Methods
Patients aged between 6 and 17 years with confirmed Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnoses of ADHD or autism spectrum disorder (ASD) were recruited from multiple institutions. In a randomized order, participants underwent 2 evaluations, face-to-face and remotely, with distinct evaluators administering the ADHD Rating Scale-IV (ADHD-RS-IV). Intraclass correlation coefficient (ICC) was used to assess the reliability of face-to-face and remote assessments.

Results
The participants included 74 Japanese children aged between 6 and 16 years who were primarily diagnosed with ADHD (43/74, 58%) or ASD (31/74, 42%). A total of 22 (30%) children were diagnosed with both conditions. The ADHD-RS-IV ICCs between face-to-face and remote assessments showed “substantial” agreement in the total ADHD-RS-IV score (ICC=0.769, 95% CI 0.654-0.849; P<.001) according to the Landis and Koch criteria. The ICC in patients with ADHD showed “almost perfect” agreement (ICC=0.816, 95% CI 0.683-0.897; P<.001), whereas in patients with ASD, it showed “substantial” agreement (ICC=0.674, 95% CI 0.420-0.831; P<.001), indicating the high reliability of both methods across both conditions.

Conclusions
Our study validated the feasibility and reliability of remote ADHD testing, which has potential benefits such as reduced hospital visits and time-saving effects. Our results highlight the potential of telemedicine in resource-limited areas, clinical trials, and treatment evaluations, necessitating further studies to explore its broader application.

Trial Registration
UMIN Clinical Trials Registry UMIN000039860; http://tinyurl.com/yp34x6kh
THE TERATOGENIC EFFECT OF DIETHYLENE GLYCOL (DEG) ON FETUS MORPHOLOGY IN WHITE MICE (MUS MUSCULUS L.)
Authors: BADRIYYA ELSA , SRANGENGE YONETA , SIREGAR JOYCE ARTHA ROSLINA , A. ALMAHDY 
Published: February 2024

Objective: Diethylene glycol is listed in the Inventory of Cosmetic Ingredients as a solvent, viscosity controller, and fragrance. Most of diethylene glycol's toxicity is caused by ingesting the contaminated product. This study aims to determine the effect of a teratogen caused by diethylene glycol on mice fetuses.
Methods: In this study, 20 mice were used, which were divided into four groups. Diethylene glycol was given with three variations of doses 1662.5, 3325, and 6650 mg/kgBW during the organogenesis period, day 6-15. The effects of teratogens observed were maternal body weight, fetal body weight, and number of fetuses, which were analyzed using one-way ANOVA, as well as morphological and skeletal abnormalities, which were analyzed descriptively.
Results: Based on the results of the study, there was a significant difference in the body weight of the mice given diethylene glycol and the control group (p<0.05). There was no significant difference in body weight and the number of fetuses in the control and treatment groups (p>0.05). On the results of fixation of Bouins' solution, defects in the form of hemorrhage, resorption sites, and slow growth were found. At the same time, the results of the fixation of alizarin red solution found defects in the sternal, nasal, caudal, metacarpal, metatarsal, and phalanges bones.
Conclusion: The conclusion based on the research is that diethylene glycol has the potential to provide teratogenic effects on mouse fetuses.
PURIFIED GAMBIR (UNCARIA GAMBIR (HUNTER) ROXB.) ATTENUATE RENAL FUNCTION IN ALLOXAN-INDUCED DIABETIC MALE RATS
Authors: RACHMAINI FITRI , ARMENIA  , ABDILLAH RAHMAD 
Published: February 2024

Objective: Diabetes and its vascular complications could prevent by antioxidants. Purified gambir is the purified extract of Uncaria gambir (Hunter) Roxb, which contains more than 90% catechins and scientifically work as antioxidant. This study aimed to determine the effect of purified gambir on renal function in alloxan-induced diabetic Wistar Kyoto rats.
Methods: Diabetic rats were induced by alloxan 125 mg/kgBW by intraperitoneal injection. Forty-five diabetic rats were divided into five groups, diabetic control group treated with vehicle, a positive control group treated with glibenclamide at dose 0.45 mg/kgBW, and treatment groups of purified gambir at doses of 2.50, 5, and 10 mg/kgBW for 14 d. Blood glucose, water intake, urine volume, creatinine clearance, renal ratio, and urine density were measured on day 3, 7, and 14. All data were analyzed by two-way ANOVA followed by Duncan Multiple Range Test.
Results: Purified gambir significantly lower blood glucose (p<0.05) and had a significant effect (p<0.05) on renal function parameters in diabetic rats. Duration of treatment purified gambir in diabetic rats had a significant effect (p<0.05) on water intake, urine volume, creatinine clearance and renal ratio.
Conclusion: This result show that purified gambir at dose 2.5 mg/kgBW increased the renal function of diabetic rats, in contrast, purified gambir at dose 5 and 10 mg/kgBW attenuate renal function of diabetic rats
Comparative study of the chemical composition of the essential oils of the aerial part of Acanthospermum hispidium D.C. 1836 collected in three towns in Ivory Coast
Authors: TIMOTOU Adéyolé , OUATTARA Logopho Hyacinthe , KAMBIRE Didjour Albert , SISSOUMA Moussa , ZON Doumadé , KABLAN Ahmont Landry Claude , BOTI Jean Brice 
Published: February 2024

This research work concerns the comparative study of the chemical composition of essential oils from the aerial part of the Acanthospermum hispidium plant collected in three towns in Côte d'Ivoire. The aim of this study is to enhance the value of aromatic and medicinal plants through the chemical analysis of essential oils (EO). The essential oils extracted using a Clevenger-type apparatus were analysed using several analytical methods, including Ir-GPC, MS-GPC and 13C-NMR. The results indicate that the essential oils of Acanthospermum hispidium are largely dominated by hydrocarbon sesquiterpenes (69.2 to 72.9%). The majority compounds identified are (E)-β-caryophyllene (33.3 to 34.9%), α-bisabolol (6.5 to 9.9%), bicyclogermacrene (6, 3 to 9.5%), germacrene D (7.3 to 8.4%), α-pinene (4.6 to 7.9%), β-lemene (3.7 to 4.3%) and α-copaene (2.5 to 3.2%). The co-presence of these compounds with multiple pharmacological properties could justify the use of A. hispidium in traditional medicine in the treatment of various pathologies.
Keywords: Acanthospermum hispidium, chemical composition, essential oil, Ivory Coast.
Phytochemical investigation and evaluation of antihyperglycemic activity of Praecitrullus fistulosus fruits
Authors: Senger Shivani Singh , Singh Anjali , Jha Megha , Jain Deepak Kumar 
Published: February 2024

Diabetes mellitus [antihyperglycemic] is the endocrine metabolic disorder characterized by raised glucose level in the sanguine liquid of body i.e. blood serum due to disturbance of carbohydrate metabolism. In Diabetes mellitus extent of glucose is maintained by well know endocrine pancreatic secreted hormone fuel called insulin which help in metabolizing the glucose level by muscular utilization and other organ pathological activity. When the levels of insulin fall below the body desire it can to hyperglycemic condition. Antihyperglycemic therapeutic plant has an ability to restore abnormal pancreatic condition by increase of insulin, enhancement of body carbohydrate utilization. There are more than 400 reported plant species used an antihyperglycemic and antihyperlipidemic. Praecitrullus fistulosus is reported to contain polyphenols, flavonoids, ascorbic acid, tannin, alkaloid, saponin, phytosterol, diterpines, thiamin, and carotene that possess antidiabetic, antioxidative and anthelmintic activity. On investigation and understanding the cause of diabetes mellitus, had opened the large view for the treatment. Phytomedicine has considerably taken the prominent position for the treatment of many metabolic disorders. Biochemical studies concluded that Praecitrullus fistulosus extract shows alteration in blood glucose level and also Praecitrullus fistulosus improved the lipid profile and showed positive aspect on different parameter in diabetic control rats and it was noted that Praecitrullus fistulosus drug extract was effective and helped in controlling the BG level in Albino Wistar Rat Praecitrullus fistulosus is reported to contain polyphenols, flavonoids, ascorbic acid, tannin, alkaloid, saponin, Phytosterol, diterpines, thiamin, and carotene that possess antidiabetic, antioxidative properties. The aim of research is to evaluate and investigate the anti-hyperglycemic activity of Praecitrullus fistulosus fruit extract on Streptozotocin (STZ)-Nicotinamide induced diabetic rat.
Keywords: Antihyperglycemic, Praecitrullus fistulosus, Phytochemicals, Phytomedicine
Comprehensive Investigation of Juniperus virginiana Essential Oil: GC/MS Analysis, Thermoanalytical Characterization, and Evaluation of Bioactive Potential
Authors: Jha Vikas , Kapadia Prakruti , Bhosale Anjali , Rumani Simeen , Patel Reetikesh , Marick Arpita , Mange Anjali , Nalawade Kavita , Hirkani Habil , Gohil Simran , Kode Ira 
Published: February 2024

Due to the ever-increasing unregulated antibiotic use, there have been increased risks of antibiotic-resistant bacterial infections. Natural agents, their products, and derivatives have been used for centuries to cure a variety of ailments. In the present study, an attempt was made to explore the physiochemical properties of the CEO. GC-MS analysis was used to identify the volatile components present in the oil. Additionally, TGA and DSC analysis were carried out to understand the thermal properties of the oil. The oil was characterized by higher amounts of terpenoids. The essential oil has potent anticancer, cytotoxic, antimalarial, and anti-inflammatory activity. This study concludes that the Juniperus virginiana essential oil could be used as a therapeutic agent.
Keywords: Anticancer, Antioxidant, Cedarwood, Cytotoxicity, Essential oil
Phytochemicals properties and antimicrobial activities of Carica papaya and Balanites aegyptiaca’ seeds aqueous infusion and decoction extracts
Authors: OUEDRAOGO Assétou , NIKIEMA Philippe Augustin , NIKIEMA Marguerite Edith Malatala , YAMEOGO Josias Gérard , SOURABIE Bernadette Pane , BASSAVE Belinda Ramata Hafouo , NIKIEMA Oueogo , GOUMBRI Florent Wendinmi Bertrand , BARRO Nicolas 
Published: February 2024

Carica papaya and Balanites aegyptiaca seeds extract have several uses, from food to traditional medicine. This study aims to determine their phytochemicals compound and appreciate their antimicrobial properties against clinical strains. Polyphenolic content was determined with standard methods while DPPH radical scavenging activity is used to appreciate the antioxidant properties, using ascorbic acid as standard. Antimicrobial activities were performed according to the inhibition diameters, using agar diffusion method. Minimum inhibitory concentrations and Minimum fungicidal concentrations were established based on broth dilution methods. The extraction yield is ranged between 6.3 and 20.3%. The results shown polyphenolic content varying from 1256.13±21.09 to 2315.81±53.52 µg GAE/100 mL for Carica papaya and from 303.98±0.93 to 948.06±3.23 µg GAE/100 mL for Balanites aegyptiaca while the antioxidant activity is ranged between 31.76±2.35 and 58.47±4.24 µg AEAC/100 mL for Carica papaya and from 29.80±0.32 to 78.44±2.81 µg AEAC/100 mL for Balanites aegyptiaca. Infusion’s extracts always have the highest values of polyphenols content and antioxidant activity than decoction extracts, be it papaya or balanites seeds. Neitheir flavonoids content nor antibacterial activity was found. The inhibition diameter varies from 14.5±0.5 to 40.5±0.5 mm for papaya seeds extracts and from 16.5±0.5 to 21.0±0.5 mm for balanites seeds extracts without a significative effect of mixture for both extracts. MICs vary from 11.71±0.1 to 75.0±0.0 mg. mL-1 for Carica papaya seeds extracts with 11.72±0.2 to 37.30±0.2 mg. mL-1 and 18.74±0.1 to 100±0.0 mg.mL-1 for Balanites aegyptiaca. Mixture extracts presented intermediaire values. Decoction extracts have lowest MICs values and infusion reveals itself to be the sweetable aqueous extraction techniques but the appropriate infusion time need to be highlight.
Keywords: Carica papaya, Balanites aegyptiaca, Seeds extracts, Phytochemical, antifungal
Anti-hyperglycemic effect of two terpenoids isolated from Coula edulis on normoglycemic rats and in silico study of their potential inhibitors on α-amylase and dipeptidylpeptidase 4
Authors: Kepawou Manuela Guaelle , Ambamba Akamba Bruno Dupon , Kamdem Michael Hermann Kengne , Piebeng Cicilien Quentin Nongni , Chimeze Valery Wilfried Nguemdjo , Ebouel Ferdinand Lanvin Edoun , Mmutlane Edwin Mpho , Ndinteh Derek Tantoh , Mbazoa Céline Djama , Ngondi Judith Laure , Wandji Jean 
Published: February 2024

Diabetes causes many deaths around the world, making the search for treatments a real challenge. Plant secondary metabolites are promising candidates because they act as scaffolds in biological processes. This study investigates anti-hyperglycaemic effect of two terpenoids isolated from Coula edulis and in silico study of their potential inhibitors on α-amylase and dipeptidypeptidase 4. After extraction and isolation of the two terpenoids, their structures were characterized using 1D and 2D NMR spectroscopic techniques. Subsequently the anti-hyperglycemic effect was achieved following an overload of starch on the one hand and glucose on the other hand in normoglycemic rats. Each isolated terpenoids was tested at a dose of 3 mg/kg.bw, the same for the reference compounds (Acarbose and glibenclamide). Conformational site analysis and docking parameters such as binding energy, inhibition constant, interaction profiles with diabetes target residues (α-amylase and dipeptidypeptidase 4) were determined using AutoDock 4.2 and Discovery Studio visualizer. The results showed that the terpenoids isolated from coula edulis were Taraxerol and 3β-(Z)-coumaroyltaraxerol, each of its two terpenoids considerably decreased the blood sugar levels in rats after overloading of starch and glucose solutions respectively. Their effects were similar to the reference drugs. Furthermore, the in-silico approach showed that these compounds have good docking scores with α-amylase and with DPP4. Taraxerol exhibited a docking score more than three times than the acarbose docking score. Only 3β-(Z)-coumaroyltaraxerol reacts with at least one amino acid of the α-amylase catalytic triad (Asp 300). Both interact with histidine (His 740) of the DPP4 catalytic triad. In view of this results, taraxerol and 3β-(Z)-coumaroyltaraxerol have anti-hyperglycemic effects and are good candidates for the development of new multitarget antidiabetics.
Keywords: Coula edulis, RMN 1D and 2D, tarxerol, 3β-(Z)-coumaroyltaraxerol and Anti-hyperglycemia
Development and Characterization of Thermoreversible In-situ Gel Containing Curcumin Nanoparticles for Nasal Delivery: Design, Ex-Vivo Study
Authors: Mamatha G. T. , Jat Rakesh Kumar 
Published: February 2024

The present study aimed to develop and evaluate thermoreversible in situ nasal gel containing Curcumin nanoparticles. Curcumin nanoparticles were prepared by the ionic gelation method. These formulations were evaluated for entrapment efficiency, particle size, zeta potential, and In vitro drug release. Particle size and zeta potential of F1 formulation were found to be 299 nm, 0.1 mV, and entrapment efficiency was found to be87.2%. From the formulations, F1 shows maximum amount of drug released in a sustained manner for a prolonged period time. Hence F1formulation was selected as optimized and further used for thermoreversible in situ nasal gel by using 2×2 factorial designs. The thermoreversible nasal gel was evaluated for the gelation temperature (33˚C), viscosity (10550cps) and spreadability (17.29±0.3 gm*cm/sec). Further, the prepared gel (F1G3) was evaluated for ex vivo permeation study for12 hours and it shows maximum amount of drug release in a controlled manner. The % CDR of thermoreversible in situ gel formulation F1G3 was found to be 86.27% which follow the Higuchi model. The 'n' value of the formulation was found to be more than 0.5. This indicate that the release approximates the non-fickain diffusion mechanism.
Keywords: Curcumin nanoparticles, Carbopol 934, PF127, Thermoreversible in situ gel, Cold method, Nasal delivery.
Utilización de residuos de pescados como alternativa para el mejoramiento de la alimentación humana y disminución del desperdicio de alimentos.
Authors: Barrera Hernández Martha , Jaimes Ariza Lady Viviana , Serrano Osma Juan Camilo 
Published: February 2024

En el 2022, según datos del sistema estadístico pesquero colombiano la pesca y la acuicultura alcanzaron una producción de 300.163 toneladas, por otra parte, en el 2022 Bogotá comercializo 3171 toneladas de pescado (Rangel et al., 2022). Por lo expuesto la industria pesquera representa grandes cantidades de residuos anualmente, lo que resulta en pérdidas económicas e impactos negativos en el medio ambiente.

Estudios realizados por estudiantes del semillero de investigación Agroalimentaria SIA de la UNAD, determinaron que en un servicio hotelero se puede llegar a desperdiciar entre 43 y 53% en variedades de pescados como corvina, mero variedad cherna y Berrugate, robalo nacional del pacífico, bagre variedad Cajaro considerando cabeza, aleta, espinazo piel y cola. Otros estudios han demostrado que dichos residuos se pueden usar de manera eficiente para múltiples propósitos: mejorar las propiedades funcionales de los alimentos, proporcionar nutrientes esenciales, obtención de gelatina, uso cosmético y en la industria de la bisutería, permitiendo el procesamiento integral de este producto. La investigación de SIA, caracterizo estos residuos, los sometió a un tratamiento de deshidratación bajo condiciones de proceso contraladas y mediante análisis fisicoquímicos incluyendo cromatografía de gases de residuos y deshidratado, se determinó que estos poseen características nutricionales incluso mejores que el filete que consumimos con presencia de ácidos grasos esenciales y sus eicosanoides, resultando ser una alternativa que disminuye el desperdicio de alimentos y aporta nutrientes esenciales que solo pueden ser sintetizados a través de la alimentación. Los ácidos grasos esenciales y sus eicosanoides se relacionan con funciones neurológicas y antiinflamatorias, asimismo en la prevención de múltiples enfermedades
Implementación de Biodigestores para el aprovechamiento de residuos en pequeñas unidades productivas agropecuarias
Authors: Valencia Achuri Paola Andrea , Abril Herrera Diego 
Published: February 2024

In isolated areas that are difficult to access for energy interconnection, it is necessary the production of alternative energies highlighting biomethane which is generated from the anaerobic digestion of organic matter. The objective of this document is to present some results of an intervention experience in 6 agricultural production units located in villages near the city of Fusagasugá, in which biodigesters were developed to improve the conditions of energy production under environmental sustainability parameters.

For the selection of the 6 productive units, there were analyzed the conditions of 21 productive units from 13 villages near the city of Fusagasugá, referenced by the Sumapáz livestock committee. The analysis was based on the availability of waste in accordance with the requirements for the proper functioning of the biodigesters, and the willingness of the owners for the implementation of biodigesters as energy complementarity in small agricultural units.

Among the most relevant results, it was found that there are drawbacks of adopting this type of alternative energy in rural productive units with the decision of only 6 properties from the 21 productive units consulted representing 28,5%, situation that shows some challenges related to strategies to connect isolated rural populations with the implementation of biodigesters as complementary energy in small agricultural units.
O jogo africano mancala no desenvolvimento de habilidades matemáticas de estudantes dos anos finais do Ensino Fundamental
Authors: Lima Paulo Vinícius Pereira de , Sousa Luciane Alves Rodrigues de , Santos Hélio Rodrigues dos , Moreira Geraldo Eustáquio 
Published: February 2024

Este artigo tem como objetivo geral investigar as concepções dos estudantes a respeito dos possíveis impactos do jogo Mancala no processo de ensino e aprendizagem nos anos finais do Ensino Fundamental. Como objetivos secundários, nos propomos a identificar as concepções dos estudantes frente à utilização do jogo Mancala, refletir sobre os possíveis benefícios para a aprendizagem em Matemática e por fim analisar se as práticas com o jogo Mancala favoreceram um melhor desempenho no campo de conhecimento da Matemática. O referido artigo buscou responder à seguinte inquietação: A utilização do jogo Mancala em sala de aula contribui para uma ruptura do ensino tradicionalista no processo de ensino e aprendizagem em Matemática dos estudantes dos anos finais do Ensino Fundamental? A pesquisa feita foi de abordagem qualitativa do tipo exploratória; como método foi utilizada a pesquisa participante e os instrumentos de coleta de dados utilizados foram o questionário e a técnica de análise de dados. Utilizou-se, ainda, a análise de conteúdo. Os resultados oriundos das análises dos questionários revelaram que o jogo Mancala assume fator diferencial, pois, além de trabalhar a Matemática, é possível abordar a cultura e as histórias africanas; contribui para o cumprimento obrigatório da Lei 10.639/03 com importantes mudanças no processo de ensino e aprendizagem dos estudantes, desmistificando o olhar que eles atribuem à disciplina de Matemática e rompem com preconceitos de que é uma área de conhecimento para poucos. Possibilitou, ainda, uma motivação a mais no que diz respeito às suas aprendizagens atinentes à disciplina de Matemática.