bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Subjective Cognitive Complaints and Incident Functional Impairment in Parkinson's Disease
Authors: Weintraub Daniel , Marras Connie , Amara Amy , Anderson Karen E. , Chahine Lana M. , Eberly Shirley , Hosamath Abhishek , Kinel Daniel , Mantri Sneha , Mathur Soania , Oakes David , Purks Jennifer L. , Standaert David G. , Shoulson Ira , Arbatti Lakshmi 
Published: February 2024

AbstractBackgroundEarly identification of subjective cognitive complaints (SCC) in Parkinson's disease (PD) may improve patient care if it predicts cognition‐related functional impairment (CFI).ObjectivesThe aim was to determine the cross‐sectional and longitudinal association between SCC and CFI in PD.MethodsData were obtained from Fox Insight, an online longitudinal study that collects PD patient‐reported outcomes. Participants completed a PD Patient Report of Problems that asked participants for their five most bothersome disease problems. SCCs were placed into eight categories through human‐in‐the‐loop curation and classification. CFI had a Penn Parkinson's Daily Activities Questionnaire (PDAQ‐15) score ≤49. Cox proportional hazards models and Kaplan–Meier survival analyses determined if baseline SCC was associated with incident CFI.ResultsThe PD‐PROP cohort (N = 21,160) was 55.8% male, mean age was 65.9 years, and PD duration was 4.8 years. At baseline, 31.9% (N = 6750) of participants reported one or more SCCs among their five most bothersome problems, including memory (13.2%), language/word finding (12.5%), and concentration/attention (9.6%). CFI occurred in 34.7% (N = 7332) of participants. At baseline, SCC was associated with CFI (P‐value <0.001). SCC at baseline was associated with incident CFI (hazard ratio [HR] = 1.58 [95% confidence interval: 1.45, 1.72], P‐value <0.001), as did cognitive impairment not otherwise specified (HR = 2.31), executive abilities (HR = 1.97), memory (HR = 1.85), and cognitive slowing (HR = 1.77) (P‐values <0.001). Kaplan–Meier curves showed that by year 3 an estimated 45% of participants with any SCC at baseline developed new‐onset CFI.ConclusionsSelf‐reported bothersome cognitive complaints are associated with new‐onset CFI in PD. Remote electronic assessment can facilitate widespread use of patient self‐report at population scale. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
A novel heterozygous mutation in PTHLH causing autosomal dominant brachydactyly type E complicated with short stature
Authors: Sun Jian , Yang Nian , Xu Zhengquan , Cheng Hongbo , Zhang Xiangxin 
Published: February 2024

AbstractBackgroundBrachydactyly type E (BDE) is a general term characterized by variable shortening of metacarpals and metatarsals, with phalanges affected frequently. It can occur as an isolated form or part of syndromes and manifest a high degree of phenotypic variability. In this study, we have identified the clinical characteristics and pathogenic causes of a four‐generation pedigree with 10 members affected by BDE and short stature.MethodsAfter the informed consent was signed, clinical data and peripheral blood samples were collected from available family members. Karyotype analysis, array‐CGH, next‐generation sequencing, and Sanger sequencing were employed to identity the pathogenic candidate gene.ResultsNo translocation or microdeletion/duplication was found in karyotype analysis and array‐CGH; hence, a novel heterozygous mutation, c.146dupA. p.S50Vfs*22, was detected by next‐generation sequencing in PTHLH gene, leading to a premature stop codon. Subsequently, the mutation was confirmed by Sanger sequencing and co‐segregation analysis.ConclusionIn this study, we described a novel heterozygous mutation (c.146dupA. p.S50Vfs*22) of gene PTHLH in a Chinese family. The mutation could induce a premature stop codon leading to a truncation of the protein. Our study broadened the mutation spectrum of PTHLH in BDE.
High common‐mode rejection balanced bandpass filter using novel coupling scheme and source‐loaded coupling technique
Authors: Cao Sainan , Liu Wang , Guan Xuehui , Ren Baoping , Xu Shaohong 
Published: February 2024

AbstractA balanced bandpass filter (BPF) with a novel coupling scheme and source‐loaded coupling (SLC) technique is proposed. The J‐inverter is directly connected to the source or load, and the single‐band cell (SBC) is fed by the J‐inverter. Meanwhile, the J‐inverter is also coupled to a resonator. Equivalent differential‐mode (DM) and common‐mode (CM) circuits are presented, and their ideal frequency responses under DM and CM are also provided. Furthermore, the SBC equals paralleled short‐ and open‐circuited stubs in DM and equals two paralleled open stubs in CM. To validate the design concept, a four‐pole balanced BPF working at 2.66 GHz with fractional bandwidth (FBW) of 13.8% is designed and fabricated. Three transmission zeros (TZs) are generated, and the upper stopband suppression level reaches 34 dB. Meanwhile, a high CM rejection level attains 54 dB within the DM passband.
A low‐profile wideband microstrip patch antenna using double half‐mode resonances
Authors: Jin Long , Zhang Ruohan , Lin Yangmiao , Zhang Xuyang , Tang Huaiyuan , Li Min 
Published: February 2024

AbstractThis paper presents a miniaturized broadband microstrip patch antenna with a simple geometry. The radiation patch of this antenna comprises two rectangular patches with slightly different sizes, one side of each patch is grounded by metal via‐holes. Two rectangular patches are connected by a microstrip line and fed by a single port. Two rectangular patches produce two closely resonant frequencies achieving broadband performance. This antenna operates on the resonant method of short‐circuiting on one side. Metal via‐holes act as a short‐circuit wall allowing each patch to operate in TM0.5,0 mode. The size of a 1/4 wavelength resonant patch is only half of a conventional microstrip antenna, the overall size of this antenna is almost as same as a conventional rectangular microstrip antenna, making it compact in size. The wideband is achieved by combining two radiating patches, resulting in stable radiation and flat gain. Measurement results show that the antenna has an impedance bandwidth of 4.355.10 GHz (15.8%) using a common dielectric substrate without air layer thickness additionally. The maximum measured realized gain is 4.61 dB. This antenna has advantages of wide bandwidth, low profile, flat gain and ease of manufacturing.
A tunable resonator enabled by a soft impedance surface
Authors: McCulloch Mark A. 
Published: February 2024

AbstractWe present a design for a cylindrical cavity resonator with a resonant frequency ( mode) that can be tuned by increasing the separation between the cavity's main body and a discrete lid. This is made possible by incorporating a soft impedance surface into the lid. Tuning between 5 and 6 GHz is achieved by increasing the lid‐to‐cavity separation from 0 to 1.5 mm. We will also discuss the field distribution within the cavity, and use it to explain how the cavity works, and limitations on the performance.
A dielectric‐loaded broadband single‐ and dual‐polarized slot antenna with low profile and low cross‐polarization
Authors: Zhang Shu‐Qing , Li Hongji , Lin Ye‐Cong , Wong Sai‐Wai 
Published: February 2024

AbstractA dielectric‐loaded slot antenna with the characteristic of broadband, low profile, and low cross‐polarization is presented. The antenna incorporating a low permittivity () and multiple high permittivity () rectangle dielectric is fed by two rectangle slot, which generates three slot modes and achieves measured 10 dB impedance bandwidth of 88 from 1.57 to 4.04 GHz covering the long term evolution (1.71–2.69 GHz) and sub‐6G (3.3–3.6 GHz). Furthermore, the presented slot antenna with a footprint of 0.81 × 0.56 and a low profile of 0.09 ( is the wavelength in the air region at the center frequency) appears the performance of measured peak gain of 9 dB without using any dielectric resonator mode. On the basis of the single‐polarized design, the dual‐polarized design with a profile of 0.09 is investigated and fabricated. According to the measured results, the dual‐polarized prototype achieves a 10‐dB impedance of 60 from 1.6 to 3 GHz.
Front‐to‐back ratio improvement of a compact base‐station antenna for 5G NR applications
Authors: Li RongLin , Huang Yuanyun , Du Jiaying , Cui Yuehui 
Published: February 2024

AbstractThe front‐to‐back ratio (FBR) of a compact dual‐polarized antenna is improved for 5G new radio (NR) base‐station applications. A rim made of partially reflective surfaces is introduced to improve the FBR. A meta‐surface and a parasitic element are employed to lower the antenna height. The dual‐polarized base‐station antenna with improved FBR features a compact size of , where is the wavelength in free space at the lowest operating frequency. The FBR achieved over the 5G NR n28/n82/n83 bands (0.69–0.96 GHz) for return loss >15 dB is higher than 26 dB. The antenna gain is higher than 7 dBi and the isolation is higher than 30 dB.
Self‐isolated quadruplexing SIW antenna with extremely low frequency ratio for C‐band applications
Authors: V. JayaPrakash , DS Chandu 
Published: February 2024

AbstractIn this letter, an substrate integrated waveguide ‐based self‐quadplexing antenna based on a modified Jerusalem cross‐shaped slot is presented. By introducing different lengths of the slots of Jerusalem cross, the antenna operates at four different closely spaced resonant frequencies 4.08, 4.37, 4.61, and 4.97 GHz. The proposed quadplexer antenna achieved a minimum port isolation of 20 dB between any two ports with an extremely low frequency ratio of 1.2. The quadplexer antenna has unidirectional radiation pattern and independent frequency tunability characteristics with a gain of 6.88, 6.51, 7.03, and 7.12 dBi, at corresponding resonant frequencies and a compact size of 0.142, where 0 is the free space wavelength at the lowest resonant frequency. The proposed antenna is suitable for C‐band multiplexing applications.
Semi‐analytical solution for ultimate bearing capacity of smooth and rough circular foundations on rock considering three‐dimensional strength
Authors: Chen Haohua , Zhu Hehua , Zhang Lianyang 
Published: February 2024

AbstractThis paper proposes a semi‐analytical solution for the ultimate bearing capacity qu of both smooth and rough circular shallow foundations on rock mass. Specifically, a three‐dimensional (3D) Hoek–Brown (HB) is adopted, in conjunction with equilibrium equations under axisymmetric conditions, to derive the governing equations. The method of characteristics is utilized to solve the stress and failure characteristics mesh to determine the qu. The proposed solution is verified by using it to analyze test foundations. Comparison with an HB criterion‐based solution is performed to highlight the importance of 3D strength. Furthermore, parametric studies are performed to investigate the effects of rock mass properties (intact rock constant , geological strength index GSI, intact rock unconfined compressive strength σc) and foundation diameter (B) on the qu, failure surface size, and vertical stress distribution on the foundation base. The results indicate that ignoring the 3D strength and the rock mass weight would lead to underestimation of qu. Besides, the ultimate bearing capacity factor (ratio of qu to σc) increases with , GSI and B but decreases with . The failure surface size is significantly affected by , GSI, B, and rock mass unit weight. The stress distribution on the foundation base has higher variance (higher possibility of stress concentration) at smaller , GSI, and larger B, rock mass unit weight.
Therapeutic efficacy of 180‐W GreenLight laser photoselective vaporization of the prostate for storage symptoms concomitant with benign prostatic obstruction and a search for outcome predictors
Authors: Hsieh Yi‐Chia , Wang Chang‐Te , Kao Yao‐Lin , Cheng Yu‐Sheng , Wu Kuan‐Yu , Ho Yi‐Hui , Chuang Ming‐Syun , Huang Yuan‐Chi , Ou Yin‐Chien 
Published: February 2024

AbstractPurposeBenign prostatic obstruction (BPO) is the most common cause of lower urinary tract symptoms among men. GreenLight photoselective vaporization of the prostate (GL‐PVP) using a 180‐W Xcelerated performance system (XPS) laser is a well‐established method for treating BPO‐induced voiding symptoms. However, its therapeutic effects on storage symptoms remain unclear. This study aimed to analyze the storage outcomes in patients who underwent 180‐W XPS GL‐PVP for BPO and to identify outcome predictors.Materials and MethodsPatients who underwent 180‐W XPS GL‐PVP for BPO between May 2018 and May 2021 were retrospectively reviewed. Data on clinical characteristics, prostate volume, preoperative and postoperative International Prostate Symptom Scores (IPSS), and preoperative urodynamic parameters were collected. A favorable storage outcome was defined as ≥50% reduction in the IPSS storage subscore.ResultsNinety‐nine male patients were included, with a mean age of 69.4 ± 9.6 years and a baseline prostatic volume of 75.9 ± 33.1 mL. The IPSS total, storage, and voiding subscores significantly decreased after GL‐PVP (all p < 0.001). Seventy‐two patients achieved favorable storage outcome at 6 months. Multivariate analysis revealed that detrusor underactivity was predictive of unfavorable storage outcomes (p = 0.022), while IPSS voiding‐to‐storage subscore ratio >1.25 and the presence of detrusor overactivity were predictive of favorable storage outcomes (p = 0.008 and 0.033, respectively).Conclusion180‐W XPS GL‐PVP provided excellent outcomes in both voiding and storage lower urinary tract symptoms concomitant with BPO. Preoperative IPSS and multichannel urodynamic parameters including detrusor overactivity and underactivity are valuable predictors of postoperative storage outcomes.
High prevalence of muscle weakness and probable sarcopenia in patients with inflammatory bowel disease
Authors: Ergenc Ilkay , Ismail Basa Chasan , Uzum Alper , Sahin Sevval , Kani Haluk Tarık , Aslan Rahmi , Tufan Aslı , Kasımay Özgür , Atuğ Özlen , Alahdab Yeşim Özen 
Published: February 2024

AbstractBackgroundThis study aimed to determine the prevalence of probable sarcopenia and sarcopenia in patients with inflammatory bowel disease (IBD) by using the European Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria.MethodsSarcopenia was assessed by using the sequential four‐step algorithm. (1) Find: Sarcopenia risk by simple clinical symptom index (strength, assistance walking, rise from a chair, climb stairs, and falls [SARC‐F questionnaire]). (2) Assess: Probable sarcopenia by low muscle strength on handgrip. (3) Confirm: Confirmed sarcopenia by low appendicular skeletal muscle mass on bioimpedance analysis. (4) Severity: Severe sarcopenia by low 4‐m gait speed test.ResultsA total of 129 adult patients with IBD younger than 65 years and 50 age‐ and sex‐matched healthy control (HC) participants were included to the study. Handgrip strength, gait speed, and SARC‐F scores were significantly lower in patients with IBD than in the HCs (P = 0.032, <0.0001, and <0.0001, respectively). Based on the EWGSOP2 definition, 17.8% of patients with IBD had probable sarcopenia, and six patients had confirmed sarcopenia. According to the ethnicity‐based population thresholds, 34.9% of patients with IBD had probable sarcopenia, and two patients had confirmed sarcopenia. Corticosteroid use within the past year was identified as an independent risk factor for low muscle strength (P = 0.012; odds ratio, 4.133), along with advanced age and disease activity.ConclusionOne‐third of the patients younger than 65 years with IBD had probable sarcopenia, defined as low muscle strength, whereas the incidence of confirmed sarcopenia remained relatively low.
On the implementation of a material point‐based arc‐length method
Authors: Gavin Nathan D. , Pretti Giuliano , Coombs William M. , Brigham John C. , Augarde Charles E. 
Published: February 2024

SummaryThe material point method is a versatile technique which can be used to solve various types of solid mechanics problems, especially those involving large deformations. However, the capability of the material point method to track a load‐displacement response can deteriorate once a limit point, such as snap‐through or snap‐back, in the response is encountered. One way of overcoming this is to use path following techniques, such as an arc‐length method. This technique is well established in finite element analysis but not within any material point method formulation. This paper provides for the first time an arc‐length controlled implicit, quasi‐static material point method. The modifications to the standard arc‐length scheme to allow for the stable execution of an arc‐length solver within the material point method are detailed. The capability of the material point‐based arc‐length method is demonstrated through a number of problems, which include linear elastic, non‐linear elastic, linear elastic‐perfectly plastic and linear elastic‐plastic softening material behaviour under large deformations. The techniques presented in this paper are essential for arc‐length techniques to be applied effectively to the material point method and the combination of these techniques makes the method suitable for new problems that cannot be solved with existing implicit material point approaches.
Application of eye‐tracking in nursing research: A scoping review
Authors: Hu Huiling , Li Huijun , Wang Binlin , Zhang Mingming , Wu Bilin , Wu Xue 
Published: February 2024

AbstractAimsTo map the themes and methods of nursing researches involving eye‐tracking as a measurement, and offer suggestion for future nursing research using eye‐tracking.DesignWe conducted a scoping review following the methodology outlined in the JBI Manual for Evidence Synthesis on scoping reviews.MethodsEligibility criteria were established based on Population (involving nursing or nursing students), Concept (utilizing eye‐tracking as a research method), and Context (in any setting). Articles were retrieved from the PubMed, Web of Science, Embase, CINAHL, APA PsycInfo, and Scopus databases, spanning from database inception to November 17, 2023. The included studies were analysed using descriptive statistics and content analysis.ResultsAfter duplicates were removed, 815 citations were identified from searches of electronic databases and other resources, and 66 met the inclusion criteria finally. Thirty‐eight studies were conducted in a simulated environment. Five application domains were identified, and most of the studies (N = 50) were observational. The domains found in our review did not cover all topics of nursing research in the same depth. Additionally, 39 studies did not solely explicate eye‐tracking data but instead integrated behavioural measures, scales/questionnaires, or other physiological data.ConclusionsEye‐tracking emerges as a significant research tool in uncovering visual behaviour, particularly in nursing research focused on nursing education. This study not only summarized the application and interpretation of eye‐tracking data but also recognized its potential in advancing clinical nursing research and practice. To effectively harness the capabilities of eye‐tracking in elucidating cognitive processes, future research should aim for a clearer grasp of the theoretical underpinnings of the addressed research problems and methodological choices. It is crucial to emphasize the standardization of eye‐tracking method reporting and ensuring data quality. No Patient or Public Contribution.
Effect of Sarcopenia on Swallowing in Patients With Head and Neck Cancer
Authors: Colback Angela A. , Arkfeld Daniel V. , Evangelista Lisa M. , Paydar Alireza , Raslan Osama , Abouyared Marianne , Cates Daniel J. 
Published: February 2024

AbstractObjectiveSarcopenia, characterized by decreased skeletal muscle mass, is associated with poorer oncologic outcomes in head and neck cancer (HNC) patients. The effect of sarcopenia on swallowing following HNC treatment is unknown. This study aims to investigate the association of sarcopenia and swallowing dysfunction in patients treated for HNC.Study DesignRetrospective cohort study.SettingAcademic medical center.MethodsPretreatment sarcopenia was assessed using the skeletal muscle index calculated from cross‐sectional imaging at the third cervical vertebra. Feeding tube dependence, patient‐reported dysphagia, and swallowing safety were assessed before and after treatment with the Functional Oral Intake Scale, Eating Assessment Tool‐10, and Penetration Aspiration Scale, respectively. The association between sarcopenia and swallowing dysfunction was evaluated.ResultsA total of 112 patients were included, 84 males (75%) and 28 females (25%). A total of 69 (61.6%) had sarcopenia prior to initiating HNC therapy. Sarcopenia was significantly associated with an elevated risk of patient‐reported dysphagia (odds ratio [OR] = 2.71 [95% confidence interval, CI, 1.12‐6.79]; P < .05). Multivariate logistic regression demonstrated that sarcopenia (OR = 15.18 [95% CI, 1.50‐453.53]; P < .05) is an independent predictor for aspiration following treatment for HNC.ConclusionPatients with pretreatment sarcopenia had higher rates of dysphagia before treatment and were more likely to develop aspiration after completion of HNC therapy. Sarcopenia is readily measured using cross‐sectional imaging and may be useful for identifying patients at risk of swallowing dysfunction and those most likely to benefit from prehabilitation efforts.
Synthesis of compounds based on the active domain of cabotegravir and their application in inhibiting tumor cells activity
Authors: Yang Ruyue , Yue Wenhui , Hu Dong , Wang Guidan , Mao Longfei , Huang Jiahe , Wang Huili , Liang Gaofeng 
Published: February 2024

AbstractStructural modification based on existing drugs, which ensures the safety of marketed drugs, is an essential approach in developing new drugs. In this study, we modified the structure of cabotegravir by introducing the front alkyne on the core structure through chemical reaction, resulting in the synthesis of 9 compounds resembling 1,2,3‐triazoles. The potential of these new cabotegravir derivatives as tumor suppressors in gastrointestinal tumors was investigated. Based on the MTT experiment, most compounds showed a reduction in the viability of KYSE30 and HCT116 cells. Notably, derivatives 5b and 5h exhibited the most significant inhibitory effects. To further explore the effects of derivatives 5b and 5h on gastrointestinal tumors, KYSE30 cells were chosen as a representative cell line. Both derivatives can effectively curtail the migration and invasion capabilities of KYSE30 cells and induce apoptosis in a dose‐dependent manner. We further demonstrated these derivatives induce cell apoptosis in KYSE30 cells by inhibiting the expression of Stat3 protein and Smad2/3 protein. Based on the above results, we suggest they show promise in developing drugs for esophageal squamous cell carcinoma.