bluuebunny/crossref_metadata_2025_split huggingface dataset:
The complexity of anatomical systems
Authors: Grizzi Fabio , Chiriva-Internati Maurizio 
Published: July 2005

AbstractBackgroundThe conception ofanatomical entitiesas a hierarchy of infinitely graduated forms and the increase in the number of observed anatomical sub-entities and structural variables has generated a growingcomplexity, thus highlighting new properties of organised biological matter.Results(1) Complexity is so pervasive in the anatomical world that it has come to be considered as a primary characteristic of anatomical systems. (2) Anatomical entities, when viewed at microscopic as well as macroscopic level of observation, show a different degree of complexity. (3) Complexity can reside in thestructureof the anatomical system (having many diverse parts with varying interactions or an intricate architecture) or in itsbehaviour. Often complexity in structure and behaviour go together. (4) Complex systems admit many descriptions (ways of looking at the system) each of which is only partially true. Each way of looking at a complex system requires its own description, its own mode of analysis and its own breaking down of the system in different parts; (5) Almost all the anatomical entities display hierarchical forms: their component structures at different spatial scales or their process at different time scales are related to each other.ConclusionThe need to find a new way of observing and measuring anatomical entities, and objectively quantifying their different structural changes, prompted us to investigate the non-Euclidean geometries and the theories of complexity, and to apply their concepts to human anatomy. This attempt has led us to reflect upon the complex significance of the shape of an observed anatomical entity. Its changes have been defined in relation to variations in itsstatus: from a normal (i.e.natural) to a pathological or altered state introducing the concepts ofkinematicsanddynamicsof anatomical forms,speedof their changes, and that ofscaleof their observation.
Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities
Authors: Janušonis Skirmantas 
Published: July 2005

Abstract

Background
A wide range of abnormalities has been reported in autistic brains, but these abnormalities may be the result of an earlier underlying developmental alteration that may no longer be evident by the time autism is diagnosed. The most consistent biological finding in autistic individuals has been their statistically elevated levels of 5-hydroxytryptamine (5-HT, serotonin) in blood platelets (platelet hyperserotonemia). The early developmental alteration of the autistic brain and the autistic platelet hyperserotonemia may be caused by the same biological factor expressed in the brain and outside the brain, respectively. Unlike the brain, blood platelets are short-lived and continue to be produced throughout the life span, suggesting that this factor may continue to operate outside the brain years after the brain is formed. The statistical distributions of the platelet 5-HT levels in normal and autistic groups have characteristic features and may contain information about the nature of this yet unidentified factor.

Results
The identity of this factor was studied by using a novel, quantitative approach that was applied to published distributions of the platelet 5-HT levels in normal and autistic groups. It was shown that the published data are consistent with the hypothesis that a factor that interferes with brain development in autism may also regulate the release of 5-HT from gut enterochromaffin cells. Numerical analysis revealed that this factor may be non-functional in autistic individuals.

Conclusion
At least some biological factors, the abnormal function of which leads to the development of the autistic brain, may regulate the release of 5-HT from the gut years after birth. If the present model is correct, it will allow future efforts to be focused on a limited number of gene candidates, some of which have not been suspected to be involved in autism (such as the 5-HT4 receptor gene) based on currently available clinical and experimental studies.
Heparan sulfate proteoglycan induces the production of NO and TNF-α by murine microglia
Authors: Bussini Simona , Meda Lucia , Scarpini Elio , Clementi Emilio , Conti Giancarlo , Tiriticco Marco , Bresolin Nereo , Baron Pierluigi 
Published: July 2005

AbstractBackgroundA common feature of Alzheimer's disease (AD) pathology is the abundance of activated microglia in neuritic plaques containing amyloid-beta protein (Aβ) and associated molecules including heparan sulfate proteoglycan (HSPG). Besides the role as pathological chaperone favouring amyloidogenesis, little is known about whether or not HSPG can induce microglial activation. Cultures of primary murine microglia were used to assess the effect of HSPG on production of proinflammatory molecules that are known to be present in neuritic plaques of AD.ResultsHSPG stimulated up-regulation of tumor necrosis factor-alpha (TNF-α), production of inducible nitric oxide synthase (iNOS) mRNA and accumulation of TNF-α protein and nitrite (NO2-) in a time- and concentration-dependent manner. The effects of HSPG were primarily due to the property of the protein core as indicated by the lack of microglial accumulation of TNF-α and NO2-in response to denaturated HSPG or heparan sulfate GAG chains (HS).ConclusionThese data demonstrate that HSPG may contribute to chronic microglial activation and neurodegeneration seen in neuritic plaques of AD.
Reporting incidence from a surveillance system with an operational case definition of unknown predictive value positive
Authors: Kegler Scott R 
Published: July 2005

AbstractWhen reporting incidence rate estimates for relatively rare health conditions, associated case counts are often assumed to follow a Poisson distribution. Case counts obtained from large-scale electronic surveillance systems are often inflated by the presence of false positives, however, and adjusted case counts based on the results of a validation sample will have variances which are hyper-Poisson. This paper presents a simple method for constructing interval estimates for incidence rates based on case counts that are adjusted downward using an estimate of the predictive value positive of the surveillance case definition.
Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA
Authors: Prichard Mark N , Lawlor Heather , Duke Gregory M , Mo Chengjun , Wang Zhaoti , Dixon Melissa , Kemble George , Kern Earl R 
Published: July 2005

Abstract

Background
Human cytomegalovirus UL114 encodes a uracil-DNA glycosylase homolog that is highly conserved in all characterized herpesviruses that infect mammals. Previous studies demonstrated that the deletion of this nonessential gene delays significantly the onset of viral DNA synthesis and results in a prolonged replication cycle. The gene product, pUL114, also appears to be important in late phase DNA synthesis presumably by introducing single stranded breaks.

Results
A series of experiments was performed to formally assign the observed phenotype to pUL114 and to characterize the function of the protein in viral replication. A cell line expressing pUL114 complemented the observed phenotype of a UL114 deletion virus in trans, confirming that the observed defects were the result of a deficiency in this gene product. Stocks of recombinant viruses without elevated levels of uracil were produced in the complementing cells; however they retained the phenotype of poor growth in normal fibroblasts suggesting that poor replication was unrelated to uracil content of input genomes. Recombinant viruses expressing epitope tagged versions of this gene demonstrated that pUL114 was expressed at early times and that it localized to viral replication compartments. This protein also coprecipitated with the DNA polymerase processivity factor, ppUL44 suggesting that these proteins associate in infected cells. This apparent interaction did not appear to require other viral proteins since ppUL44 could recruit pUL114 to the nucleus in uninfected cells. An analysis of DNA replication kinetics revealed that the initial rate of DNA synthesis and the accumulation of progeny viral genomes were significantly reduced compared to the parent virus.

Conclusion
These data suggest that pUL114 associates with ppUL44 and that it functions as part of the viral DNA replication complex to increase the efficiency of both early and late phase viral DNA synthesis.
Animal models of attention-deficit hyperactivity disorder
Authors: Russell Vivienne A , Sagvolden Terje , Johansen Espen Borgå 
Published: July 2005

AbstractAlthough animals cannot be used to study complex human behaviour such as language, they do have similar basic functions. In fact, human disorders that have animal models are better understood than disorders that do not. ADHD is a heterogeneous disorder. The relatively simple nervous systems of rodent models have enabled identification of neurobiological changes that underlie certain aspects of ADHD behaviour. Several animal models of ADHD suggest that the dopaminergic system is functionally impaired. Some animal models have decreased extracellular dopamine concentrations and upregulated postsynaptic dopamine D1 receptors (DRD1) while others have increased extracellular dopamine concentrations. In the latter case, dopamine pathways are suggested to be hyperactive. However, stimulus-evoked release of dopamine is often decreased in these models, which is consistent with impaired dopamine transmission. It is possible that the behavioural characteristics of ADHD result from impaired dopamine modulation of neurotransmission in cortico-striato-thalamo-cortical circuits. There is considerable evidence to suggest that the noradrenergic system is poorly controlled by hypofunctional α2-autoreceptors in some models, giving rise to inappropriately increased release of norepinephrine. Aspects of ADHD behaviour may result from an imbalance between increased noradrenergic and decreased dopaminergic regulation of neural circuits that involve the prefrontal cortex. Animal models of ADHD also suggest that neural circuits may be altered in the brains of children with ADHD. It is therefore of particular importance to study animal models of the disorder and not normal animals. Evidence obtained from animal models suggests that psychostimulants may not be acting on the dopamine transporter to produce the expected increase in extracellular dopamine concentration in ADHD. There is evidence to suggest that psychostimulants may decrease motor activity by increasing serotonin levels. In addition to providing unique insights into the neurobiology of ADHD, animal models are also being used to test new drugs that can be used to alleviate the symptoms of ADHD.
Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon
Authors: Boignard Aude , Salvat-Melis Muriel , Carpentier Patrick H , Minson Christopher T , Grange Laurent , Duc Catherine , Sarrot-Reynauld Françoise , Cracowski Jean-Luc 
Published: July 2005

AbstractAccurate and sensitive measurement techniques are a key issue in the quantification of the microvascular and endothelial dysfunction in systemic sclerosis (SSc). Thermal hyperhemia comprises two separate mechanisms: an initial peak that is axon reflex mediated; and a sustained plateau phase that is nitric oxide dependent. The main objective of our study was to test whether thermal hyperhemia in patients with SSc differed from that in patients with primary Raynaud's phenomenon (RP) and healthy controls. In a first study, we enrolled 20 patients suffering from SSc, 20 patients with primary RP and 20 healthy volunteers. All subjects were in a fasting state. Post-occlusive hyperhemia, 0.4 mg sublingual nitroglycerin challenge and thermal hyperhemia were performed using laser Doppler flowmetry on the distal pad of the third left finger. In a second study, thermal hyperhemia was performed in 10 patients with rheumatoid arthritis and 10 patients with primary RP. The thermal hyperhemia was dramatically altered in terms of amplitude and kinetics in patients with SSc. Whereas 19 healthy volunteers and 18 patients with primary RP exhibited the classic response, including an initial peak within the first 10 minutes followed by a nadir and a second peak, this occurred only in four of the SSc patients (p < 0.0001). The 10 minutes thermal peak was 43.4 (23.2 to 63), 42.6 (31 to 80.7) and 27 (14.7 to 51.4) mV/mm Hg in the healthy volunteers, primary RP and SSc groups, respectively (p = 0.01), while the 44°C thermal peak was 43.1 (21.3 to 62.1), 42.6 (31.6 to 74.3) and 25.4 (15 to 52.4) mV/mm Hg, respectively (p = 0.01). Thermal hyperhemia was more sensitive and specific than post-occlusive hyperhemia for differentiating SSc from primary RP. In patients with rheumatoid arthritis, thermal hyperhemia was also altered in terms of amplitude. Thermal hyperhemia is dramatically altered in patients with secondary RP in comparison with subjects with primary RP. Further studies are required to determine the mechanisms of this altered response, and whether it may provide additional information in a clinical setting.
Structure‐Mapping: A Theoretical Framework for Analogy*
Authors: Gentner Dedre 
Published: July 2005

A theory of analogy must describe how the meaning of an analogy is derived from the meanings of its parts. In the structure‐mapping theory, the interpretation rules are characterized as implicit rules for mapping knowledge about a base domain into a target domain. Two important features of the theory are (a) the rules depend only on syntactic properties of the knowledge representation, and not on the specific content of the domains; and (b) the theoretical framework allows analogies to be distinguished cleanly from literal similarity statements, applications of abstractions, and other kinds of comparisons.Two mapping principles are described: (a) Relations between objects, rather than attributes of objects, are mapped from base to target; and (b) The particular relations mapped are determined by systematicity, as defined by the existence of higher‐order relations.
Reconstructive Memory: A Computer Model*
Authors: Kolodner Janet L. 
Published: July 2005

This study presents a process model of very long‐term episodic memory. The process presented is a reconstructive process. The process involves application of three kinds of reconstructive strategies—component‐to‐context instantiation strategies, component‐instantiation strategies, and context‐to‐context instantiation strategies. The first is used to direct search to appropriate conceptual categories in memory. The other two are used to direct search within the chosen conceptual category. A fourth type of strategy, called executive search strategies, guide search for concepts related to the one targeted for retrieval.A conceptual memory organization implied by human reconstructive memory is presented along with examples which motivate it. A basic retrieval algorithm is presented for traversing that stucture. Retrieval strategies arise from failures in that algorithm. The memory organization and retrieval processes are implemented in a computer program called CYRUS which stores events in the lives of former Secretaries of State Cyrus Vance and Edmund Muskie and answers questions posed in English concerning that information. Examples which motivate the process model are drawn from protocols of human memory search. Examples of CYRUS's behavior demonstrate the implemented process model. Conclusions are drawn concerning retrieval failures and the relationship of episodic and semantic memory.
Beyond the Purely Cognitive: Belief Systems, Social Cognitions, and Metacognitions As Driving Forces in Intellectual Performance*
Authors: Schoenfeld Alan H. 
Published: July 2005

This study explores the way that belief systems, interactions with social or experimental environments, and skills at the “control” level in decision‐making shape people's behavior as they solve problems. It is argued that problem‐solvers' beliefs (not necessarily consciously held) about what is useful in mathematics may determine the set of “cognitive resources” at their disposal as they do mathematics. Such beliefs may, for example, render inaccessible to them large bodies of information that are stored in long‐term memory and that are easily retrieved in other circumstances. In other cases, individuals' reactions to an experimental setting (fear of failure, or the desire to “look mathematical” while being videotaped) may induce behavior that is almost pathological—and at the same time, so consistent that it can be modeled. In general, such “environmental” factors establish the context within which individuals access and utilize the information potentially at their disposal.Protocols illustrating these points are presented and discussed. A model based on an axiomatization of students' beliefs about plane geometry is outlined, and is shown to correspond closely to their problem‐solving performance. A framework is offered for analyzing problem‐solving performance at three qualitatively different levels: access to cognitive resources stored in LTM, executive or control decision‐making, and belief systems.
An Attempt to Understand Students' Understanding of Basic Algebra*
Authors: Sleeman D. 
Published: July 2005

This paper reports the results obtained with a group of 24 14‐year‐old students when presented with a set of algebra tasks by the Leeds Modelling System, LMS. These same students were given a comparable paper‐and‐pencil test and detailed interviews some four months later. The latter studies uncovered several kinds of student misunderstandings that LMS had not detected. Some students had profound misunderstandings of algebraic notation: Others used strategies such as substituting numbers for variables until the equation balanced. Additionally, it appears that the student errors fall into several distinct classes: namely, manipulative, parsing, clerical, and “random.”LMS and its rule database have been enhanced as the result of this experiment, and LMS is now able to diagnose the majority of the errors encountered in this experiment. Finally, the paper gives a process‐oriented explanation for student errors, and re‐examines related work in cognitive modelling in the light of the types of student errors reported in this experiment. Misgeneralization is a mechanism suggested to explain some of the mal‐rules noted in this study.
Systematicity and Surface Similarity in the Development of Analogy
Authors: Gentner Dedre , Toupin Cecile 
Published: July 2005

This research investigates the development of analogy: In particular, we wish to study the development of systematicity in analogy. Systematicity refers to the mapping of systems of mutually constraining relations, such as causal chains or chains of implication. A preference for systematic mappings is a central aspect of analogical processing in adults (Gentner, 1980, 1983). This research asks two questions: Does systematicity make analogical mapping easier? And, if so, when, developmentally, do children become able to utilize systematicity?Children aged 5–7 and 8–10 acted out stories with toy characters. Then they were asked to act out the same stories with new characters. Two variables were manipulated: systematicity, or the degree of explicit causal structure in the original stories, and the transparency of the object‐mappings. Transparency was manipulated by varying the similarity between the original characters and the corresponding new characters: it was included in order to vary the difficulty of the transfer task. If children can utilize systematicity, then their transfer accuracy should be greater for systematic stories.The results show: (1) As expected, transparency strongly influenced transfer accuracy (for both age groups, transfer accuracy dropped sharply as the object correspondences became less transparent); and (2) for the older group, there was also a strong effect of systematicity and an interaction between the two variables. Given a systematic story, 9‐year‐olds could transfer it accurately regardless of the transparency of the object correspondence.
Negative Regulation of Growth Hormone Receptor Signaling
Authors: Flores-Morales Amilcar , Greenhalgh Christopher J. , Norstedt Gunnar , Rico-Bautista Elizabeth 
Published: July 2005

AbstractGH has been of significant scientific interest for decades because of its capacity to dramatically change physiological growth parameters. Furthermore, GH interacts with a range of other hormonal pathways and is an established pharmacological agent for which novel therapeutical applications can be foreseen. It is easy to see the requirement for a number of postreceptor mechanisms to regulate and control target tissue sensitivity to this versatile hormone. In recent years, some of the components that take part in the down-regulatory mechanism targeting the activated GH receptor (GHR) have been defined, and the physiological significance of some of these key components has begun to be characterized. Down-regulation of the GHR is achieved through a complex mechanism that involves rapid ubiquitin-dependent endocytosis of the receptor, the action of tyrosine phosphatases, and the degradation by the proteasome. The suppressors of cytokine signaling (SOCS) protein family, particularly SOCS2, plays an important role in regulating GH actions. The aim of this review is to summarize collected knowledge, including very recent findings, regarding the intracellular mechanisms responsible for the GHR signaling down-regulation. Insights into these mechanisms can be of relevance to several aspects of GH research. It can help to understand growth-related disease conditions, to explain GH resistance, and may be used to develop pharmaceuticals that enhance some the beneficial actions of endogenously secreted GH in a tissue-specific manner.
Preparation and Properties of Reduced-Charge Smectites — A Review
Authors: Komadel Peter , Madejová Jana , Bujdák Juraj 
Published: July 2005

AbstractLayer charge reduction of selected homoionic swelling clay minerals upon heating is reviewed. This phenomenon is known for Li+-montmorillonites as the Hofmann-Klemen effect. Aspects covered in the review include: mechanism of the charge reduction caused by the irreversible migration of small cations into the mineral layers; final sites of the fixed cations in the octahedral and/or tetrahedral sheets, as deduced on the basis of structural and spectroscopic data obtained in several studies; effects of octahedral and tetrahedral components of the layer charge; properties of the exchangeable cations; and the chemistry and structure of the mineral on charge reduction. Current knowledge has been summarized on the changes of various mineral properties connected with charge reduction, including the loss of swelling and the decrease in the cation exchange capacity, the most important change upon cation fixation. Also discussed are the preparation, properties, and advantages of uses of series of reduced-charge montmorillonites (RCMs) in research; interactions of RCMs with alkylammonium cations and organic cationic dyes, with some examples on the interactions with organic polymers and other organic compounds. Properties of organo-complexes and composite materials prepared from RCMs are also included in this review.