bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD9 marks myeloid/MegE-biased human hematopoiesis
Authors: Safi Fatemeh , Dhapola Parashar , Sommarin Mikael N.E. , Karlsson Göran 
Published: October 2023

Abstract
Rare hematopoietic stem cells make up an infrequent but critical population in the bone marrow (BM), maintaining and replenishing the entire hematopoietic system. Importantly, despite sharing the unique stem cell properties of multilineage differentiation and self-renewal, individual HSCs are functionally heterogeneous, and this heterogeneity increases during aging. While HSCs in young mice are qualitatively more similar, ageing is marked by an increased size of the HSC pool and substantial functional variation of individual HSCs. CD9 is a cell surface marker that is highly expressed in HSCs in mice, while CD9 expression within the human HSC population has been reported to be low during neonatal hematopoiesis. Here, we have investigated CD9 expression levels in the human HSPC population over time and identified that early in life; CD9 is infrequent in HSCs, but marks progenitor populations with low engraftment potential and high proliferation capacity. However, during situations of myeloid/Megakaryocyte-erythoid (MegE) biased hematopoiesis, such as during ageing or in leukemia, there is a substantial increase of CD9 expression in HSPCs. Thus, CD9 represents an HSC marker for myeloid/MegE-biased hematopoiesis.
Inpatient Opioid Withdrawal: A Qualitative Study of the Patient Perspective
Authors: Babbel Danielle , Liu Patricia , Chen David R. , Vaughn Valerie M. , Zickmund Susan , Bloomquist Kennedi , Zickmund Tobias , Howell Elizabeth F. , Johnson Stacy A. 
Published: October 2023

Abstract

Background and Objectives
Opioid withdrawal is common among hospitalized patients. Those with substance use disorders exhibit higher rates of patient-directed discharge. The literature lacks information regarding the patient perspective on opioid withdrawal in the hospital setting. In this study, we aimed to capture the patient-reported experience of opioid withdrawal during hospitalization, and its impact on the desire to continue treatment for opioid use disorder after discharge.
Methods
We performed a single-center qualitative study involving semi-structured interviews of hospitalized patients with OUD experiencing opioid withdrawal. Investigators conducted in-person interviews utilizing a combination of open-ended and dichotomous questions. Interview transcripts were then analyzed with open-coding for emergent themes.
Results
Nineteen interviews were performed. All participants were linked to either buprenorphine (79%) or methadone (21%) at discharge. Eight of nineteen patients (42%) reported a patient-directed discharge during prior hospitalizations. Themes identified from the interviews included: 1) opioid withdrawal was well-managed in the hospital; 2) participants appreciated the receipt of medication for opioid use disorder (MOUD) for withdrawal symptoms; 3) they valued and felt cared for by healthcare providers; and 4) most participants had plans to follow-up for opioid use disorder treatment after hospitalization.
Conclusions
In this population historically reporting high rates of patient-directed discharge, participants reported having a positive experience with opioid withdrawal management during hospitalization. Several individualized MOUD induction strategies were observed. All participants were offered MOUD at discharge and most planned to follow-up for further treatment.
Sun declination and distribution of solar resources on Earth
Authors: Rueda José A. , Sánchez Miguel A. , Hernández Wilber , Aguilar Cecilio U. 
Published: October 2023

Abstract
The daily path of the Sun across longitude yields night and day, but the Sun also travels across latitude, on a belt 47° wide. The budget of solar resources that the sunrays supply to a location depends on the angle at which they land. The sun meridian declination, along with its velocity and acceleration, as well as the latitudinal distribution of the solar resources, were assessed in terms of beam radiation. The analysis is founded on the geometric model of solar declination. The functions describing the declination, velocity, and acceleration of the apparent Sun resemble one another when plotted against time. Whereas, the functions of declination vs velocity and velocity vs acceleration approach a circle. One third of the beam radiation that the Sun delivers to the Earth along the year, halves between two latitudinal belts 3.5° wide, next to the tropics of Cancer and Capricorn. Surprisingly, the belt 0 to 20° harvests a budget similar to that of two belts 20 to 23.5° (33%). The distribution of beam radiation follows the same pattern in either hemisphere. All sites whose latitude converge, whether within or between hemispheres, accumulate an equivalent budget of solar heat and light from beam radiation.
Dry Needling in a Multimodal Rehabilitation Protocol Following Rotator Cuff Repair Surgery: A randomized double-blinded sham- controlled trial
Authors: Naseri Faeze , Dadgoo Mehdi , Pourahmadi Mohammadreza , Amroodi Morteza Nakhaei , Azizi Shirin , Tabrizian Pouria , Shamsi Amirhossein , Amiri Ali , Ashani Hamideh Mirzaei 
Published: October 2023

Abstract
Background
Rotator cuff repair (RCR) is one of the most prevalent procedures to manage rotator cuff tears (RCT). Postoperative shoulder pain is a common complication following RCR and may be aggravated by activation of myofascial trigger points (MTrP) associated with the injury to the soft tissues surrounding the surgical incision, prolonging the patients' time to recovery.
Purpose
This study aimed to evaluate the effectiveness of myofascial trigger point dry needling (MTrP-DN) as a muscle treatment approach along with a multimodal rehabilitation protocol (MRh) on postoperative shoulder pain, range of motion (ROM), strength, and functional outcome scores for patients following RCR surgery.
Methods
Forty-six patients aged 40–75 following the RCR surgery were recruited and randomly allocated into 2 groups: (1) MTrP-DN plus MRh (experimental group) and (2) sham dry needling (S-DN) plus MRh (control group). This trial had a 4-week intervention period. The primary outcome was the Numeric Pain Rating Scale (NPRS) for pain. Secondary outcomes were the Shoulder Pain and Disability Index (SPDI), ROM, and strength. In the current study, adverse events were recorded as well.
Results
We found significant within-group differences in all outcome measures (p < 0.001). But no significant between-group differences were detected in any of the outcomes (p > 0.05). This study reported minor adverse events following the needling approach.
Conclusion
According to the study's findings, adding 4 sessions of MTrPDN to 4 weeks of MRh did not significantly improve postoperative shoulder pain, ROM, strength, or SPDI. This study also revealed minor adverse events after the needling procedure.
Trial registration:
This trial was registered at the (https://www.irct.ir), (IRCT20211005052677N1) on 19/2/2022.
Taurine: A double-edged sword in reducing atherosclerotic plaque formation
Authors: Wei Meng-Guang , Ying Ang , Huang Feng-Qing , Wang Feng-Xiang , Alolga Raphael N. , Qi Lian-Wen , Ma Gaoxiang , Liu Qun 
Published: October 2023

Abstract
Purpose
The role of taurine in the development of atherosclerosis remains controversial. Taurine supplementation may attenuate atherosclerosis by reducing lipid levels, while energy drinks containing taurine have been shown to increase blood pressure, a key risk factor for atherosclerosis. The aim of this study is to measure the levels of taurine in the plasma of patients with acute coronary syndrome and investigate the effect of taurine on the susceptibility of atherosclerotic plaques to rupture.
Methods
A 1,2-13C2-taurine-labeled quantification method by UPLC-QQQ-MS/MS was used to measure the plasma levels of taurine in 105 patients with coronary heart disease. A carotid artery cannula mouse model was used to assess the effect of taurine on plaque formation.
Results
The level of taurine was significantly higher in the plasma of patients with coronary heart disease (4.04 µg/mL ± 0.24 µg/mL) compared to healthy controls (3.52 µg/mL ± 0.22 µg/mL). Taurine administration was found to decrease plaque area in carotid artery cannula ApoE−/− mice, but also increased the susceptibility of plaque to rupture, as indicated by Masson's Trichrome staining and α-SMA/CD68.
Conclusion
While taurine supplementation may reduce the size of atherosclerotic plaques, it may also increase the risk of plaque rupture. Therefore, the use of dietary supplements containing taurine should be done with caution.
Interventions to promote cost-effectiveness in adult Intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study
Authors: Kansal Amit , Latour Jos M. , See Kay Choong , Rai Sumeet , Cecconi Maurizo , Britto Carl , Morris Andrew Conway , Savio Raymond Dominic , Nadkarni Vinay M. , Rao BK , Mishra Rajesh 
Published: October 2023

Abstract
Background
There is limited evidence to guide interventions that promote cost-effectiveness in adult intensive care units (ICU). The aim of this consensus statement is to identify globally applicable interventions for best ICU practice and provide guidance for judicious use of resources.
Methods
A three-round modified online Delphi process, using a web-based platform sought consensus from 61 multidisciplinary ICU experts (physicians, nurses, allied health, administrators) from 21 countries. Round 1 was qualitative to ascertain opinions on cost-effectiveness criteria based on four key domains of high-value healthcare (foundational elements; infrastructure fundamentals; care delivery priorities; reliability and feedback). Round 2 was qualitative and quantitative, while round 3 was quantitative to reiterate and establish criteria. Both rounds 2 and 3 utilised a five-point Likert scale for voting. Consensus was considered when > 70% of the experts voted for a proposed intervention. Thereafter, the steering group endorsed interventions that were identified as ‘critical’ by more than 50% of steering group members. These interventions and experts’ comments were summarized as final considerations for best practice.
Results
At the conclusion of round 3, consensus was obtained on 50 best practice considerations for cost-effectiveness in adult ICU. Finally, the steering group endorsed 9 ‘critical’ best practice considerations. This included adoption of a multidisciplinary ICU model of care, focus on staff training and competency assessment, ongoing quality audits, thus ensuring high quality of critical care services whether within or outside the four walls of ICUs, implementation of a dynamic staff roster, multidisciplinary approach to implementing end-of-life care, early mobilization and promoting international consensus efforts on the Green ICU concept.
Conclusions
This Delphi study with international experts resulted in 9 consensus statements and best practice considerations promoting cost-effectiveness in adult ICUs. Stakeholders (government bodies, professional societies) must lead the efforts to identify locally applicable specifics while working within these best practice considerations with the available resources.
Unlocking the High Photosensitivity Direct Laser Writing: Designing Structures and Observing Atomic Clustering in Glass
Authors: Qiao Xvsheng , Zheng Wenyan , Wang Zhuo , Chen Weilin , Xu Qiang , Tan Dezhi , Zhang Junjie , Qiu Jianrong , Qian Guodong , Fan Xianping 
Published: October 2023

Abstract

The direct laser writing (DLW) of photoluminescent metal clusters is inspiring intensive research in functional glasses. However, the impact of the host structure on cluster formation and visualization of DLW-induced clusters at the atomic scale remains challenging. In this work, we developed a highly photosensitive fluorophosphate glass matrix through fluorine incorporation. The addition of fluorine established a conducive environment for Ag+ ions before DLW and enhanced the availability of reducing agents and diffusion pathways during DLW. These advantages facilitate the formation of Ag quantum clusters (Ag QCs) dots under low-energy single-pulsed DLW. Increasing laser energy resulted in a combination of Ag QCs and glasses defect, forming a dot + ring photoluminescent pattern. To directly visualize the Ag QCs, we employed atom probe tomography (APT), a technique capable of mapping the spatial distribution and quantifying the number of Ag QCs. APT results demonstrated that DLW effectively halves the distance between adjacent Ag+ ions, leading to a significant increase in the abundance of Ag QCs with various aggregations, as well as a 31-fold increase in cluster density. The design concept and characterization enrich our understanding of Ag QCs behavior in glasses. This new knowledge opens up possibilities for the rational design of clusters confined in glasses and inspires their directed synthesis and various applications.
Impact of feralisation on evolutionary trajectories in the genomes of feral cat island populations
Authors: Koch Katrin , Nieto-Blázquez María Esther , Gómez-Suárez Manuela , Pfenninger Markus 
Published: October 2023

Abstract
Background
Feralisation is the process of domesticated animals returning to the wild, and it is considered the counterpart of domestication. Molecular genetic changes are well documented in domesticated organisms but understudied in feral populations. In this study, the genetic differentiation between domestic and feral cats was inferred by analysing whole-genome sequencing data of two geographically distant feral cat island populations (Dirk Hartog Island (Australia) and Kaho’olawe (Hawaii)), as well as domestic cats and European wildcats. The study investigated population structure, genetic differentiation, genetic diversity, highly differentiated genes, and recombination rates.
Results
Genetic structure analyses linked both feral cat populations to North American domestic cat populations. Recombination rates in feral cats were lower than in domestic cats but higher than in wildcats. For Australian and Hawaiian feral cats, 78 and 65 highly differentiated genes compared to domestic cats, respectively, were identified. Annotated genes had similar functions, with almost 50% of the divergent genes related to nervous system development. Only five mutually highly differentiated genes were found in both feral populations. Evolution of highly differentiated genes was likely driven by specific demographic histories, the relaxation of the selective pressures associated with domestication, and adaptation to novel environments to a minor extent. Random drift was the prevailing force driving highly divergent regions, with relaxed selection in feral populations also playing a significant role in differentiation from domestic cats.
Conclusions
The study demonstrates that feralisation in cats is not just the reversal of domestication, but an independent process that brings feral cats on a unique evolutionary trajectory.
Skin incision in total mastectomy and relationship to indocyanine green angiography with assessment of skin flap perfusion
Authors: Yoshino Maho , Nakagawa Tsuyoshi , Uetake Hiroyuki , Oda Goshi , Ogawa Ayumi , Hayashi Kumiko , Mori Hiroki , Fujioka Tomoyuki , Mori Mio 
Published: October 2023

Abstract

Background
This study investigated the cause of skin flap necrosis following total mastectomy to prevent skin flap necrosis.
Methods
For 79 patients who underwent total mastectomy at our institution, the skin incision line was set at operation, and each dissection distance from the skin incision line to the area of mastectomy was measured and photographed. The photographs were analyzed to determine the skin resection area. The approximate area of the total anterior chest on the operative side was also measured by preoperative positron emission tomography-computed tomography (PET-CT) to determine the ratio of the skin resection area to total anterior chest area on the operative side. The results were compared for the necrosis and non-necrosis groups.
Results
The skin resection area and the perimeter of the skin incision line were significantly greater in the necrosis group (p = 0.009, 0.004); the ratio of the skin resection area to total anterior chest area on the operative side was also significantly greater in the necrosis group (p = 0.005). Intraoperative indocyanine green angiography showed significant differences in the skin resection area and the ratio of the skin resection area to anterior chest area (p = 0.006, 0.025) compared between the cases with areas of relative perfusion ≤ 11% and two other groups. The skin resection area affected blood perfusion of the skin flap, causing a partial reduction in blood flow.
Conclusions
In total mastectomy, larger skin resection significantly increases the risk of necrosis due to reduced blood perfusion of the skin flap.
Predictors for Interest to Participate in Digital Mental Health Therapy: A Cross-Sectional Survey of Individuals with Anxiety and Depression
Authors: Gunawardena Tharidu , Bartholmae Marilyn , Karpov Matvey , Dod Rohan , Ahuja Kripa , Rajendran Aishwarya , Kathrotia Mayuri , Dodani Sunita 
Published: October 2023

Abstract

Background:
Due to a multitude of factors, the onset of the COVID-19 pandemic resulted in a significant increase in mental health issues within society, including depression and anxiety. Due to the increased trend of mental health disorders in society, digital mental health therapies are more useful than ever. With the emergence of programs utilizing Internet Cognitive Behavioral Therapy (iCBT), mental health resources are easily accessible and can be widely implemented to those in need.
The aim of this study was to identify predictors for interest to participate in SilverCloud Digital Mental Health Therapy among individuals with mild to severe anxiety and/or depression based on preliminary findings from the COVIDsmart study.
Methods:
COVIDsmart study participants who indicated they would like to participate in future studies derived from COVIDsmart findings and who had moderate to severe anxiety and/or depression, were invited to complete a needs assessment survey to determine eligibility for the SilverCloud study using Research Electronic Data Capture (REDCap). The needs assessment was used to evaluate reasons for high levels of anxiety and/or depression during COVID-19. Additionally, participants were asked to indicate if they would be interested in receiving free digital mental health services. Descriptive statistics were used to analyze the demographics of participants. Furthermore, a logistic regression was used to find predictors for interest in participation in SilverCloud. SAS 9.4 was used and p values <0.05 were considered significant.
Results:
Out of the COVIDsmart participants who took part in the SilverCloud needs assessment, 120 individuals completed it. The largest demographic among these participants were females (70.83%) who identified as White (80.83%). The mean age was 48.74 years (SD = 14.66). Results revealed that having a mental health comorbidity significantly predicted the likelihood of interest in participating in the SilverCloud digital mental health program (p= 0.027).
Conclusions:
Individuals with pre-existing mental health conditions should receive additional screening and treatment to detect the possibility of newly emerging depression and/or anxiety. These results have significant implications for healthcare settings and mental health clinics regarding the utilization of screenings and treatment.
Silver-modified atraumatic restorative treatment in managing early childhood caries. 1-year clinical results of “SMART” technique in primary teeth: A retrospective study
Authors: AKSOY Merve , SARI Makbule Buse DUNDAR , SOZUOZ Melis ARDA , GUNGOR Erva , BAL Cenkhan 
Published: October 2023

Abstract
Objectives: This retrospective study aimed to assess the 12-month clinical success of the silver-modified atraumatic restorative treatment (SMART) technique in primary teeth.
Materials and Methods: The analyses (Modified- United States Public Health Service criteria) were performed on retrospective clinical records (3-6-12 months) of 53 cases (2-6 years, no spontaneous pain-sensitivity to percussion-palpation) treated with the SMART technique during the pandemic. The teeth were divided into groups by location (Mandibular-Maxillary) and cavity preparation (Class-1-2-3). P-value <0.05 was accepted as statistically significant.
Results: The success rate of retention, marginal discoloration, and secondary caries in the mandibula (84.8%), was higher than the values detected in the maxilla (38.5%) and teeth with Class-1 cavity preparation were significantly more successful at 12-month assessments (p=0.038). Mandibular cases and Class-1 cavities revealed better results in marginal adaptation assessments (78.8%, and 88.9%, respectively).
Conclusion: SMART can be a preferable alternative for short-term applications in the management of carious primary teeth of young children with dental anxiety.
Clinical Relevance: This study highlights an alternative treatment approach that focuses on caries arresting in children with dental anxiety at least for a period until the child becomes more mature and able to comply with the advanced treatment procedure.
High sensitivity and specificity in fetal gender identification in the first trimester, using ultrasound and Noninvasive Prenatal Screening (NIPS) in twin pregnancies, a prospective study
Authors: Svirsky Ran , Sharabi-Nov Adi , Sagie Tal , Meiri Hamutal , Adi Orenstein , Kugler Nadav , Maymon Ron 
Published: October 2023

Abstract
Introduction: Determination of the fetal gender in the first trimester is important in twin pregnancy cases of familial X-linked genetic syndromes and helps determine chorionicity. We assessed and compared the accuracy of first-trimester ultrasound scans, and cell-free fetal DNA (CfDNA) in determining fetal gender in the first trimester of twin pregnancies. Methods: Women with twin pregnancies were recruited prospectively during the first trimester. Fetal gender was determined using both ultrasound scans and CfDNA screening. Both results were compared to the newborn gender after delivery. Results: A total of 113 women with twin pregnancies were enrolled. There was 100% sensitivity and specificity in Y chromosome detection using CfDNA. Gender assignment using ultrasound in any first-trimester scans was 79.7%. Accuracy level increased from 54.2% in CRL 45–54 mm to 87.7% in CRL 55–67 mm and 91.5% in CRL 67–87 mm. Male fetuses had significantly higher chances of a gender assignment error compared to female fetuses, odds ratio = 23.574 (CI 7.346–75.656). Conclusions: CfDNA is highly sensitive and specific in determining the presence of the Y chromosome in twin pregnancies in the first trimester. Between CRL 55–87 mm, ultrasound scanning offers a highly accurate determination of fetal gender in twin pregnancies.