bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of p53 codon 72 polymorphism with weight and metabolic diseases in a Central Indian population
Authors: Abraham Jessy , Mahapatra Deepak , Agrawal Pratishtha , James Mary Jovita 
Published: January 2024

Abstract
Background
Metabolic dysregulation leading to diabetes is a major public health concern in India. While evidence has pointed to a role for genetic factors, there is still limited knowledge regarding the specific variants that play a part in this process. Recent studies have implicated Tumor protein, p53, a well-known tumor suppressor, in maintaining metabolic homeostasis in our body. Polymorphisms that can disrupt this function are thought to increase susceptibility to diabetic and prediabetic phenotypes like Metabolic syndrome (MetS). A common polymorphism at codon 72 (rs1042522) is associated with obesity and other metabolic disorders. However, its role may vary depending on the specific population and disease context. Our study aimed to evaluate whether the polymorphism at codon 72 of p53 (rs1042522) is associated with MetS and Diabetes, in a Central Indian population.

Results
A total of 66 individuals and 63 healthy controls, identified based on the National Cholesterol Education Program (NCEP)/Adult Treatment Panel-III (ATP-III) 2001 guidelines, were enrolled in the study. The carriers expressing mutant allele “G” for arginine at codon 72 had higher weight than those having wild-type allele “C” which codes for proline (p = 0.038). The majority of the subjects were heterozygous for p53 codon 72 polymorphism though the association was not statistically significant for either MetS or diabetes.

Conclusion
Our findings suggest that p53 codon 72 (rs1042522) varaints may trigger metabolic dysfunction by impacting weight. The polymorphism appears to confer a heterozygous advantage, as individuals with a heterozygous genotype exhibited the highest susceptibility to metabolic disease. Although further studies are required, our results for the first time indicate that the p53 codon 72 (rs1042522) polymorphism could be considered a genetic marker to predict the increased susceptibility to diabetic and prediabetic phenotypes among Central Indian population.
Pediatric precision: navigating the complexity of mycotic pseudoaneurysms in ascending aorta post-atrial septal defect repair—a case report
Authors: Soundararajan Anand Shankar , Pandiyan Aishwarya , Sundaramoorthy Ezhilnambi , Balasubramani Kathirvel , Shakir H. R. Haroon , Jaikaran G. K. 
Published: January 2024

Abstract
Background
This case report elucidates the exceptional rarity and intricacies surrounding mycotic pseudoaneurysms in the ascending aorta, specifically post-pediatric cardiac surgery.

Case presentation
The case report presents a distinctive case of a 7-year-old female developing complications 10 days after atrial septal defect repair, characterized by sternal wound infection attributed to Pseudomonas aeruginosa. Imaging revealed a substantial pseudoaneurysm, necessitating a meticulous surgical strategy involving femoral cannulation, redo sternotomy, and adept management of intraoperative challenges, such as a fragile sternum and dense adhesions. The successful postoperative course, marked by weaning and comprehensive management, contributes significant insights into the evolving landscape of mycotic pseudoaneurysms in pediatric populations. The discussion delves into the historical context, mechanisms, and causative organisms, emphasizing the heightened vigilance required in the postoperative care of this vulnerable demographic.

Conclusion
This report enhances our understanding of pediatric cases, underscoring the imperative for increased awareness and strategic management in addressing post-cardiac surgery complications.
Assessment of the protective and ameliorative impact of quercetin nanoparticles against neuronal damage induced in the hippocampus by acrolein
Authors: Sanad Samia M. , Nassar Safaa E. , Farouk Reham 
Published: January 2024

Abstract
Background
The most frequent kind of dementia in the senior population is Alzheimer's disease (AD). Antioxidant quercetin has a low bioavailability. The bioavailability of quercetin nanoparticles was demonstrated to be higher. Acrolein is thought to be the strongest unsaturated aldehyde. Acrolein contributes to the propagation of oxidative damage and thus the aetiology of AD. This study aimed to investigate histopathological and ultrastructural changes that may arise in the hippocampus following acrolein treatment. Quercetin nanoparticles' ameliorative and protective effects on acrolein-induced neurotoxicity and oxidative stress were assessed.

Results
We successfully synthesised quercetin nanoparticles with uniform size distributions and particle diameters in the range of 3.63–4.57 nm using transmission electron microscopy (TEM) and 3.7 nm using dynamic light scattering (DLS). Administration of acrolein was associated with histopathological alterations in the hippocampal structure, such as increased apoptotic neurones, dystrophic changes, neuronophagia, and atrophic ischaemia in cells, as well as marked damage to the ultrastructure of the hippocampus, which was obvious in shrunken pyramidal neurones with pyknotic nuclei and completely degenerated chromatin material, as well as in damaged astrocytes and microglial cells. Treatment with quercetin nanoparticles has been found to protect against and ameliorate the toxic effects and oxidative stress induced by acrolein in the hippocampus.

Conclusions
This could pave the way for additional research in nanomedicine and a new line of therapeutic intervention in AD using nanoparticles such as quercetin nanoparticles.
Successful domestication of
Neonothopanus Hygrophanus
(Mont.) De Kesel & Degreef and
Lentinus Squarrosulus
Mont., indigenous saprophytic edible mushrooms from Kibira National Park in Burundi
Authors: Nteziryayo Vincent , Mshandete Anthony M. , Tibuhwa Donatha D. 
Published: January 2024

Abstract

Background
Mushroom cultivation in Burundi provides an excellent way to diversify agricultural production although domestication of mushroom species is at an infancy stage. The country is endowed with indigenous forests that harbour a wide diversity of mushrooms with potential for domestication. This study was undertaken to explore opportunities for domestication of saprophytic wild edible mushrooms from the Kibira National Park (KNP) in Burundi.

Methods

Samples of
Lentinus squarrosulus
Mont. and
Neonothopanus hygrophanus
(Mont.) De Kesel & Degreef were collected from the field, and tissue cultured on Potato Dextrose Agar (PDA) medium. Spawn production and development was performed on sorghum grains and lignocellulosic substrates respectively and the parameters of mycelial growth and mushroom yield were determined.

Results

The germplasm of
L. squarrosulus
and
N. hygrophanus
was successfully isolated with an average tissue culture incubation time of 6.4 ± 0.54 days and 7.6 ± 0.54 days for
L. squarrosulus
and
N. hygrophanus
, respectively. Spawn production incubation time on sorghum grains was 12.6 ± 0.89 days and 14.8 ± 0.83 days for
L. squarrosulus
and
N. hygrophanus
, respectively. For full colonization of lignocellulosic substrates, spawn production time ranged between 19 ± 1 and 21 ± 1 days for
L. squarrosulus
and between 17 ± 1.22 and 18 ± 1.22 days for
N. hygrophanus
. Both species successfully produced fruiting bodies and mushrooms yielded at a rate of 18.24 ± 9.76 to 22.85 ± 9.16% for
L. squarrosulus
and 12.66 ± 8.95 to 15.3 ± 8.94% for
N. hygrophanus
which is here reported for the first time to be successfully domesticated. For both species, the cottonseed hulls substrate comparatively showed the best yield followed by the combination of maize cobs/soybean straws (MC + SBS) (50:50), the combination of rice straws/soybean straws (RS + SBS) (50:50) and the maize cobs substrate respectively, while the rice straw showed the least. The combinations of MC + SBS (50:50) and RS + SBS (50:50) showed a yield close to that of cottonseed hulls.

Conclusions

For the first-time, this study presents successful domestication of
N. hygrophanus
and
L. squarrosulus
from KNP. It is concluded that the substrates combinations used in the study give good yields, and therefore recommended for use as cost-effective and efficient alternative substrates.
Incidencia y factores de riesgo en la ototoxicidad por cisplatino
Authors: Benito Orejas José Ignacio , Sánchez-Martínez Ana , Tavárez-Rodríguez Juan José , Morais-Pérez Darío , Soto De Prado-Otero Diego , Muñoz-Moreno María Fe 
Published: January 2024

Introducción y objetivos: El cisplatino es uno de los fármacos de uso clínico con mayor ototoxicidad. Controlando los umbrales auditivos de los pacientes en tratamiento, podemos realizar una detección precoz de la hipoacusia y adoptar medidas terapéuticas. Con este trabajo pretendemos evaluar la incidencia y severidad de la hipoacusia por cisplatino en nuestro medio, identificando los principales factores de riesgo.
Métodos: Monitorización y registro, en un hospital de tercer nivel, de la pérdida auditiva por cisplatino, en los primeros 100 pacientes enviados por oncología que aceptan el seguimiento audiológico, aplicando la audiometría de alta frecuencia y las otoemisiones acústicas.
Resultados: Se trata de una población fundamentalmente adulta, con una edad media de 59 años. De los 70 pacientes tratados sólo con cisplatino un 27% manifestó la aparición o el incremento de su hipoacusia. En los 30 restantes, que además de cisplatino recibieron radioterapia, detectamos afectación auditiva en el 53%. Los efectos ototóxicos del cisplatino son dosis dependiente y más intensos con audición normal. En nuestros resultados, ni el género, ni la edad, ni la presencia de hipoacusia previa, fueron factores estadísticamente significativos en la vulnerabilidad.
Conclusiones: La susceptibilidad variable al daño ototóxico, el inicio clínicamente insidioso y su irreversibilidad, justifican la conveniencia de monitorizar la ototoxicidad por cisplatino. Los datos clínicos nos permiten calcular el riesgo medio de una población, aunque no sirvan para predecir lo que le ocurrirá a un paciente en concreto.
“That’s just, like, your opinion” – European citizens’ ability to distinguish factual information from opinion
Authors: Goldberg Andreas C. , Marquart Franziska 
Published: January 2024

Abstract
In the current media landscape, it is becoming increasingly difficult for citizens to rely on trustworthy information, not least because reliable facts are mixed with dubious claims, unsubstantiated opinions, or outright lies. The ability to distinguish factual from other types of mediated information is becoming increasingly crucial, but we know little about how well-equipped citizens are to make these distinctions. In an original survey study conducted in ten European countries, we asked respondents whether they considered six different statements relating to the European Union to be factual or opinion statements. Our results show that citizens have considerable difficulties in correctly identifying both factual information and opinions. Next to pre-existing judgements, we identify media-related, political, and sociodemographic factors that influence categorisation accuracy. We discuss our findings in relation to citizens’ perceptions of journalistic credibility and their information literacy as well as ongoing debates about the effectiveness of fact-checkers on social media.
Poetic Emancipation:

Wissenschaft des Judentums and the Study of Folk-Narratives
Authors: Schrire Dani 
Published: January 2024

Abstract
The present article aims at explaining the unique role the study of folk-narrative played in the Wissenschaft des Judentums (the scholarly study of Judaism) as it emerged in the nineteenth century and first half of the twentieth century and as it was negotiated later. This article engages how the language of Wissenschaft constructed Jewish texts in the language of folk-narrative studies. And how the language of folk-narrative studies constructed Jewish culture in the language of Wissenschaft. Given the status of scholars within this movement – Jews who were citizens of European nations – they demonstrated the affinities between Jewish folk-narrative traditions and Islamic narrative traditions; on the other hand, they used a poetic language that implemented European (mainly German) genres and forms of scholarship that were viewed as objective and scientific in their studies of Jewish texts. The article examines three works by three scholars from three generations of the Wissenschaft movement: Moritz Steinschneider, Ignaz Goldziehr and Bernhard Heller – each corresponding respectively to one genre: legend, myth and folktale.
Ein übersehenes Märchen von Dorothea Viehmann
Authors: Ehrhardt Holger 
Published: January 2024

Abstract
Although the Brothers Grimm give a different indication of origin for the fairy tale Die weiße und die schwarze Braut
(KHM 135), the correspondence of characteristic linguistic phenomena with the fairy tales of Dorothea Viehmann suggests that this tale could also have been contributed by her. With the help of the “original version” from the Berlin Grimm estate, a wealth of further linguistic-stylistic and lexical-motif evidence is presented that corroborates this attribution. Considerations of the history of transmission, biography, and biography of the work make this assumption plausible, as do codicological and comparative analyses of the manuscript.
The Wicked Stepmother
Authors: van Opstall Emilie 
Published: January 2024

Abstract
The story of Syntipas/the Seven Sages travelled as an international bestseller through the Near East and Europe, from the Middle Ages up to Early Modernity, and was adapted by its translators to each new context. Belonging to the genre of wisdom literature, it circulated in over thirty languages and under various titles. This article addresses processes of creative adaptation in different cultural contexts by comparing two early versions, the Book of Syntipas the Philosopher in Greek from the eleventh century and Dolopathos in Latin from the twelfth century. By way of case study, it offers an analysis of the ‘bedroom scene’ in both versions and discusses the different ways with which female agency is dealt.
(Re)-Killing of a Sacred Deer: Myths, Ecology, and Hegemony in Murathan Mungan’s Deer Curses
Authors: Yilmaz Baris 
Published: January 2024

Abstract
This article traces the motif of the deer hunt from ancient Greek texts to its reinterpretation in contemporary Turkish literature. The motif, which appears frequently in both ancient Greek myths and the legends of Central Asian warrior Turkish societies, is reproduced as a fusion in the works of contemporary Turkish writer Murathan Mungan (*1955). The meanings attached to the motif take on a different dimension during this reproduction, which has implications for themes such as taboo, transgression, and the hierarchy of animal-human relationships in folk narrative. An analysis of Mungan’s play Deer Curses can aid in elucidating the points of folk narrative in regard to these themes and anthropocentrism. This article thus investigates how the motif of the deer hunt, among other deer-related motifs, is revived in a contemporary literary work and what type of conclusions it may bring in analyzing human-animal relationships, as well as hegemony, through a symbolic reading of this relationship.
Expression of Subdued Voices in Select Folktales of Kashmir: A Subaltern Approach
Authors: Mir Beenish , Bhattacharya Jayatee , Gayas Gazala 
Published: January 2024

Abstract
Certain voices in society and history fade away with the passage of time because they lack the freedom of expression. These are typically the voices of the oppressed or subjugated section of the society. Their voices, however, can be heard in literature as they subsequently turn to it to articulate their thoughts, and folk literature or folklore is no exception in this regard. Drawing inspiration from the subaltern perspective, this paper argues that folktales of Kashmir gave voice to the subaltern of the Kashmiri society. For this purpose, it examines three Kashmiri folktales titled The Tale of the Farmer’s Wife and the Honey-Bee, The Story of A Weaver, and The Clever Jackal following a subaltern approach to demonstrate how themes, narratives, and characters represent the subdued voices.
Acquiring elastic properties of thin composite structure from vibrational testing data
Authors: Aksenov Vitalii , Vasyukov Alexey , Beklemysheva Katerina 
Published: January 2024

Abstract
The paper is devoted to a problem of acquiring elastic properties of a composite material
from the vibration testing data with a simplified experimental acquisition scheme.
The specimen is considered to abide by the linear elasticity laws and subject to viscoelastic damping.
The boundary value problem for transverse movement of such a specimen in the frequency domain is formulated and solved with finite-element method.
The correction method is suggested for the finite element matrices to account for the mass of the accelerometer.
The problem of acquiring the elastic parameters is then formulated as a nonlinear least-square optimization problem.
The usage of the automatic differentiation technique for stable and efficient computation of the gradient and hessian allows to use well-studied first and second order local optimization methods.
We also explore the possibility of generating initial guesses for local minimization by heuristic global methods.
The results of the numerical experiments on simulated data are analyzed in order to provide insights for the following real life experiments.
The Moderating Role of Demographic Factors in the Relationship among Job Satisfaction, Work Environment, Work Motivation to Employee Performance
Authors: Hanafi Kemal Muhammad , Syah Tantri Yanuar Rahmat 
Published: January 2024

The purpose of this study was to determine the effect of job satisfaction, work environment, and work motivation on employee performance and to determine the role of gender and duration as demographic factors that moderate the relationship between job satisfaction, work environment, work motivation, and employee performance. The object of this study is employees with staff positions working in telecommunications companies to PT. XL Axiata, PT. Indosat Ooredoo, and PT. Telekomunikasi Indonesia (Telkomsel) located in Jakarta. This study uses a quantitative approach which will use a questionnaire measuring tool. The total sample of this study was 590 respondents using a simple random sampling technique. To analyze the data used univariate cell means test and multiple linear regression test. The results of this study conclude that job satisfaction, work environment, and work motivation have a significant effect on employee performance. Demographic factors that become moderating have an influence on employee performance, but the exception for male gender is not better than women in job satisfaction, work environment, and work motivation on employee performance, while for work duration more than two years it is better than less than two years in the work environment and work motivation on employee performance, and are inversely related to job satisfaction.
Dynamic Capital Structure and Its Speed of Adjustment: a Case of Listed Manufacturing Firms in Indonesia
Authors: Anisti Novia Putri , Chalid Dony Abdul 
Published: January 2024

This study examines the determining factors and the speed of adjustment of manufacturing firms’ capital structure in Indonesia. This research uses data of 118 listed manufacturing companies from 2014 to 2018 and offers a continuation of Indonesia’s existing literature by applying a dynamic model. The results reveal that Indonesian manufacturing firms practice optimal capital structure and are altered by firm-specific and time-varying factors. Firms’ decisions regarding capital structure are determined by firm-specific factors: non-debt tax shields, tangibility, and stock price performance. The results also indicate the speed of adjustment does exist, although the speed of adjustment finds lower than in previous research. The slowdown of the manufacturing industry growth from 2014 to 2018 turns out to be in line with the slow pace of leverage adjustment.
War, Women and Post-conflict Empowerment: Lessons from Sierra Leone
Authors: Dana Zikho 
Published: January 2024

War, Women and Post-conflict Empowerment: Lessons from Sierra Leone, edited by Josephine Beoku-Betts and Fredline A. M’Cormack-Hale uses an African Feminist theory to explicate how issues such as class, race, gender, religion, ethnicity, and heteronormativity intersect and are shaped by women in the African context, specifically in the war and post war contexts. The book offers conceptual frameworks embedded in “African centred gendered analysis” which privileges African lived realities and localised understandings of empowerment and development over dominant Western neoliberal conceptual frameworks. It does this by showcasing various womanhood and motherhood strategies used by women in Sierra Leone to end the 11-year Civil War (1991–2002). Equally so, the book divulges various ways women’s mass mobilisation has contributed to post-war Sierra Leone which saw the passage of landmark laws that protect women from patriarchal violations that predate the 11-year Civil War.
.Insecticidal Effect and Chemical Composition of Some Essential Oils on Larval Survival of Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) in Laboratory Conditions
Authors: YANDAYAN GENÇ Hanife , SARAN Ceren , AKÇURA Sevim 
Published: January 2024

Aims:The Mediterranean fruit fly, medfly, Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) is a serious pest of many fruits and vegetables. This study was conducted to determine antifeeding and insecticidal activities of some essential oils extracted from Pelargonium graveolens (Geraniaceae), geranium, Lavandula intermedia Mill. (Lamiaceae), lavender, Nigella sativa L. (Ranunculaceae) black cumin, and Laurus nobilis L. (Lauraceae), laurel, against second instars of the Medfly on artificial diet.
Material and Methods:The essential oils were obtained by Clevenger-type water distillation and a laboratory reared medfly colony was used in the study. Each tested essential oils with 6 different doses were distributed over the artificial diet in a Petri dish having 20 larvae. All experiments were performed under laboratory conditions of 23±1°C, 50% RH and 16: 8 (L:D) photoperiods. Probit MsChart was used to estimate LC50 and LC90 values of the tested essential oils. GGE Biplot analyzes were created with the larval mortality based on the different essential oil doses.

Results: As results, the highest larval mortality was determined with addition of laurel and black cumin oils into the diet. The highest mortality was detected in black cumin oil at the lowest concentrations. Based on GGE Biplot analyzes, the essential oil of black cumin has observable larvicidal properties.
Discussion: The results were provided fundemental information about insecticidal and antifeeding properties of the medfly in laboratory.
Conclusions:Further studies needed to integrate sustainable management programmes with natural insecticides against the medfly larvae.