bluuebunny/crossref_metadata_2025_split huggingface dataset:
Narrative review of application of metagenomic approaches to study the link between oropharyngeal microbiome and infectious diseases
Authors: Diallo Kanny , Missa Kouassi Firmin , Tuo Jeremie Kolotioloman , Amoikon Tiemele Laurent Simon , Bla Brice K. , Bonfoh Bassirou 
Published: December 2023

ContextViral and bacterial infections are major causes of morbidity and mortality worldwide. The oropharyngeal microbiome could play an important role in preventing invasion of viral and bacterial pathogens by modulating its content and the host’s innate immune response. Next Generation Sequencing (NGS) technologies now enable in-depth study of the genomes of microbial communities. The objective of this review is to highlight how metagenomics has contributed to establish links between changes in the oropharyngeal microbiome and emergence of bacterial and viral diseases.MethodTwo search engines, PubMed and Google scholar were used with filters to focus searches on peer-reviewed original articles published between January 2010 and September 2022. Different keywords were used and only articles with metagenomic approaches were included.ResultsThis review shows that there were few articles studying the link between oropharyngeal microbiome and infectious diseases. Studies on viruses using metagenomic techniques have been growing exponentially in recent years due to the Covid-19 pandemic. This review shows that most studies still focus on the basic identification of microorganisms in different disease states and multiple microorganisms (Alloprevotella, Prevotella, Bacteroides, Haemophilus, Streptococcus, Klebsiella sp., Acinetobacter sp…), have been associated with development of infections such as childhood wheezing, influenza, Covid-19, pneumonia, meningitis, and tuberculosis.ConclusionThe oropharyngeal microbiome, despite its importance, remains poorly studied. A limited number of articles were identified but this number has increased exponentially since 2020 due to research conducted on Covid-19. These studies have shown that metagenomic has contributed to the unbiased identification of bacteria that could be used as biomarkers of various diseases and that further research is now needed to capitalize on those findings for human health benefit.
Patient-reported experiences during and following treatment with belantamab mafodotin for relapsed/refractory multiple myeloma in the DREAMM-2 study
Authors: Cardellino Anna , Correll Julia R. , Martin Mona , Gorsh Boris , Sapra Sandhya , Popat Rakesh 
Published: December 2023

IntroductionPatients with relapsed or refractory multiple myeloma (RRMM) are likely to be living with persistent symptoms, especially bone pain and fatigue, and experiencing restrictions in their physical and social functioning, which reduce health-related quality of life.MethodsThis qualitative interview study evaluated patients’ perspectives about living with RRMM and their treatment with belantamab mafodotin, using interviews embedded in the Phase II DREAMM-2 trial (NCT03525678) with belantamab mafodotin. Patients consented to participate in up to 2 recorded telephone interviews (at treatment cycle 4 [C4] and at end of treatment [EOT]) comprising open-ended questions.ResultsA total of 142 interviews were conducted with 111 unique patients. At C4, common symptoms included neuropathy, fatigue, and bone or joint pain. Improvements in symptom severity were reported by patients who responded to belantamab mafodotin. Symptoms associated with visual impairment, eye irritation, and eye pain reported during the trial were reported to be at- or near-resolution by the EOT interview. Regarding impacts of underlying MM, patients most commonly expressed concerns about changes in daily performance and lifestyle for both responders (67.5% of all impact expressions) and non-responders (63.2%). Overall, interview participants reported being satisfied with belantamab mafodotin treatment.DiscussionThis qualitative patient interview study provides valuable insight into patients’ symptomatic experience with belantamab mafodotin for their RRMM treatment and may help healthcare providers better anticipate their patients’ real-world experience and needs when prescribing this novel agent in the clinic.
CT-based radiomics nomogram for overall survival prediction in patients with cervical cancer treated with concurrent chemoradiotherapy
Authors: Xu Chao , Liu Wen , Zhao Qi , Zhang Lu , Yin Minyue , Zhou Juying , Zhu Jinzhou , Qin Songbing 
Published: December 2023

Background and purposeTo establish and validate a hybrid radiomics model to predict overall survival in cervical cancer patients receiving concurrent chemoradiotherapy (CCRT).MethodsWe retrospectively collected 367 cervical cancer patients receiving chemoradiotherapy from the First Affiliated Hospital of Soochow University in China and divided them into a training set and a test set in a ratio of 7:3. Handcrafted and deep learning (DL)-based radiomics features were extracted from the contrast-enhanced computed tomography (CT), and the two types of radiomics signatures were calculated based on the features selected using the least absolute shrinkage and selection operator (LASSO) Cox regression. A hybrid radiomics nomogram was constructed by integrating independent clinical risk factors, handcrafted radiomics signature, and DL-based radiomics signature in the training set and was validated in the test set.ResultsThe hybrid radiomics nomogram exhibited favorable performance in predicting overall survival, with areas under the receiver operating characteristic curve (AUCs) for 1, 3, and 5 years in the training set of 0.833, 0.777, and 0.871, respectively, and in the test set of 0.811, 0.713, and 0.730, respectively. Furthermore, the hybrid radiomics nomogram outperformed the single clinical model, handcrafted radiomics signature, and DL-based radiomics signature in both the training (C-index: 0.793) and test sets (C-index: 0.721). The calibration curves and decision curve analysis (DCA) indicated that our hybrid nomogram had good calibration and clinical benefits. Finally, our hybrid nomogram demonstrated value in stratifying patients into high- and low-risk groups (cutoff value: 5.6).ConclusionA high-performance hybrid radiomics model based on pre-radiotherapy CT was established, presenting strengths in risk stratification.
Structure and function of microbiomes in the rhizosphere and endosphere response to temperature and precipitation variation in Inner Mongolia steppes
Authors: Song Wenchen , Wang Yao , Peng Bo , Yang Linyan , Gao Jian , Xiao Chunwang 
Published: December 2023

IntroductionOwing to challenges in the study of complex rhizosphere and endophytic microbial communities, the composition and function of such microbial communities in steppe ecosystems remain elusive. Here, we studied the microbial communities of the rhizosphere and endophytic microbes of the dominant plant species across the Inner Mongolian steppes using metagenomic sequencing and investigated their relationships with changes in mean annual temperature (MAT) and mean annual precipitation (MAP).MethodsMetagenomic sequencing based on Illumina high-throughput sequencing, using the paired end method to construct a small fragment library for sequencing.ResultsAdaptation of root systems to the environment affected the composition and function of rhizosphere and endophytic microbial communities. However, these communities exhibited distinct community assembly and environmental adaptation patterns. Both rhizosphere and endophytic microbial communities can be divided into two unrelated systems based on their ecological niches. The composition and function of the rhizosphere microbial communities were mainly influenced by MAT, while those of the endophytic microbial communities were mainly influenced by MAP. MAT affected the growth, reproduction, and lipid decomposition of rhizosphere microorganisms, whereas MAP affected reverse transcription and cell wall/membrane/envelope biogenic functions of endophytic microorganisms.ConclusionOur findings reveal the composition and function of the rhizosphere and endophytic microbial communities in response to changes in MAP and MAT, which has important implications for future biogeography and climate change research.
Ecological drivers for poultry farms predisposed to highly pathogenic avian influenza virus infection during the initial phase of the six outbreaks between 2010–2021: a nationwide study in South Korea
Authors: Min Kyung-Duk , Yoo Dae-sung 
Published: December 2023

BackgroundHighly pathogenic avian influenza (HPAI) has caused substantial economic losses worldwide. An understanding of the environmental drivers that contribute to spillover transmission from wild birds to poultry farms is important for predicting areas at risk of introduction and developing risk-based surveillance strategies. We conducted an epidemiological study using data from six HPAI outbreak events in South Korea.Materials and methodsAn aggregate-level study design was implemented using third-level administrative units in South Korea. Only regions with high natural reservoir suitability were included. The incidence of HPAI at chicken and duck farms during the initial phase (30 and 45 days after the first case) of each outbreak event was used as the outcome variable, assuming that cross-species transmission from wild birds was the dominant exposure leading to infection. Candidate environmental drivers were meteorological factors, including temperature, precipitation, humidity, and altitude, as well as the proportion of protected area, farm density, deforestation level, and predator species richness. Logistic regression models were implemented; conditional autoregression models were used in cases of spatial autocorrelation of residuals.ResultsLower temperature, higher farm density, and lower predator species richness were significantly associated with a higher risk of HPAI infection on chicken farms. Lower temperature, higher proportion of protected area, and lower predator species richness were significantly associated with a higher risk of HPAI infection on duck farms.ConclusionThe predicted dominant transmission routes on chicken and duck farms were horizontal and spillover, respectively. These results reveal a potential protective effect of predator species richness against HPAI outbreaks. Further studies are required to confirm a causal relationship.
PENYULUHAN KESEHATAN PENDAMPINGAN PRAKTEK PEMASANGAN TENSOCREPE SENDI
Authors: Aji Rustam , Dewi Mursidah , Handayani Tri , Wahyuddi Munadiah , Ratih FSA Sherly , Ajhie Ayuningtyas Roro 
Published: December 2023

Latar Belakang: Keseleo (dislocations) dapat terjadi secara tiba-tiba tanpa kita sadari,kjadiannya bisa di rumah maupun di luar rumah, pada saat bekerja, berolah raga , bermain dan lain sebagainya. Perlu penanganan yang tepat, karena tensocrepe merupakan salah satu alat sederhana. Pada Pertolongan Pertama Pada Kecelakaan (P3K) yang dibutuhkan terutama untuk pertolongan pada korban, keseleo.Tujuan: Siswa memahami tentang keseleo dan dapat mempraktekkan dan memberikan tensocrepe pada sendi yang keseleo. Agar sendi yag cedera tidak bergeser sehingga menghindari meluasnya cedera pada jaringan otot di sekitar tulang sendi yang cedera. Hasil Kegiatan : Penyuluhan dihadiri siswa klas.IV. SDN.07 Rejang Lebong 10 siswa perempuan dan 11 laki-laki, 98 % siswa bisa menjawab kuis pertanyaan langsung tentang keseleo dan dapat mempraktekkan dan memberikan tensocrepe pada sendi yang keseleo. Rencana Tindak Lanjut : Akan dilaksanakan kegiatan pelatihan pemasangan tensocrepe pada kelas lainnya.Pembahasan : Pemasangan tensocrepe merupakan pertolongan pertama pada sendi yang mengalami cedera keseleo, dengan cara mempertahankan posisi sendi yang cedera menggunakan pemasangan tensocrepe, dapat menjaga posisi yang stabil, dan cedera tidak meluas. Kesimpulan : 98 % siswa bisa menjawab kuis pertanyaan langsung tentang keseleo dan dapat mempraktekkan dan memberikan tensocrepe pada sendi yang keseleo (dislocations). agar ssendi yang cedera tidak bergeser sehingga menghindari meluasnya cedera pada jaringan otot di sekitar tulang sendi yang cedera. Saran: Siswa yang telah diberikan pelatihan pemasangan tensocrepe,sebaiknya melakukan sosialisasi pada teman dan keluarga.
Everything fails for a cause: understanding medical diagnostic error using reliability and maintainability engineering
Authors: Franke Alexander , Sehly Amro A. 
Published: December 2023

<p>The objective of this prospective cohort study was to assess the marginal gain in diagnostic accuracy when physical examination and interpretation of technological tests are added to history taking. In this study, 258 patients were assessed consecutively by two physicians at two Acute Medical Units (AMU) and one emergency department (ED) at three teaching hospitals. After talking to each patient, differential diagnoses were listed, with confidence scores. These lists were modified after each subsequent station of information gathering, that is, physical examination and interpretation of technological tests. A diagnosis was defined as accurate if at least one differential was confirmed at the subsequent encounter with a healthcare provider. The observation period was 4.2 years. </p>
<p>Traditional regression analysis found that physician inexperience predicted error. The hazard curve for diagnostic error for the lower experience condition initially decreased but after 3.3 years increased steadily. The hazard curve for the higher experience condition continued to decrease with time, beyond 4 years. Regression analysis did not find other predictors of diagnostic error. However, reliability analysis found patient comorbidity combined with diagnoses that remained unchanged after history taking were factors. Interpretation of the errors using the principles of heuristics, that is, cognitive biases that putatively caused the errors, gave contradictory explanations.</p>
<p>Applying reliability analysis provided useful information when regression analysis failed to detect explanatory factors for diagnostic errors. Reliability analysis demonstrates the limited utility of explaining diagnostic error because of cognitive biases.</p>
ENSURING THE SAFETY OF EMPLOYEES OF THE AIC PROCESSING ENTERPRISE
Authors: Савельев А.П. , Чугунов М.Н. , Еналеева С.А. , Глотов С.В. , Чугунов А.М. 
Published: December 2023

Проблема и цель. Целью исследований являлось обеспечение пожарной безопасности работников перерабатывающего предприятия комплекса. Методология. Исследования проведены с применением аналитического метода, с использованием натурного обследования и сопоставления. Результаты. Статья посвящена исследованию безопасности работников одного из перерабатывающих предприятий агропромышленного комплекса Республики Мордовия. С учетом возможных и реализуемых последствий, наиболее значимым является обеспечение пожарной безопасности. Наличие горючих материалов в сырье, технологическом оборудовании и готовой продукции создает пожароопасную обстановку, а в случае возникновения пожара может представлять реальную угрозу жизни и здоровью людей. Для обеспечения безопасности работников необходимо объективно оценивать противопожарное состояние предприятия, которое включает анализ возможности возникновения пожара, анализ способности системы пожарной безопасности снизить интенсивность его развития и минимизировать материальные потери от пожара, но главное – оценить уровень безопасности людей. Заключение. Количественной величиной оценки уровня обеспечения безопасности людей является риск. Существующая нормативно-правовая база позволяет производить оценку пожарных рисков промышленных предприятий. В статье приведены результаты оценки безопасности персонала перерабатывающего предприятия АПК на основе пожарного риска.
Problem and purpose. The purpose of the research was to ensure the fire safety of employees of the processing plant of the agro complex. Methodology. The studies were carried out using the analytical method, field examination and comparison. Results. The article is devoted to the study of the safety of employees of one of the processing enterprises of the agro-industrial complex of the Republic of Mordovia. Taking into account possible and realizable consequences, fire safety is most significant. The presence of combustible materials in raw materials, process equipment and finished products creates a fire hazardous situation, and in the event of a fire, it can pose a real threat to human life and health.To ensure the safety of employees, it is necessary to assess the fire-prevention state of the enterprise objectively, which includes an analysis of the possibility of a fire, an analysis of the ability of the fire safety system to reduce the intensity of its development and minimize material losses from a fire, but most importantly, to assess the level of people's safety. Conclusion. The quantitative value of the assessment of the level of ensuring the safety of people is the risk. The existing regulatory and legal framework allows assessment of fire risks of industrial enterprises. The article presents the results of assessing the safety of the personnel of the processing enterprise of the agro-industrial complex on the basis of fire risk.
KEPATUHAN MINUM OBAT KLIEN TUBERKULOSIS PARU DI PUSKESMAS SIDOSERMO SURABAYA
Authors: Erfah  , Hepta Nur Anugraheni  , Padolipdl  
Published: December 2023

ABSTRAK
Tuberkulosis Paru (TB Paru) merupakan salah satu penyakit yang telah lama dikenal dan sampai saat ini masih merupakan masalah kesehatan diberbagai negara di dunia. Kepatuhan pengobatan merupakan kunci pemberantasan dan penyembuhan TB Paru. Tujuan penelitian ini adalah mengetahui kepatuhan klien TB Paru dalam menjalani pengobatan TB. Jenis penelitian adalah deskriptif yang mendeskripsikan tentang kepatuhan minum obat pada klien TB paru yang menjalani pengobatan. Populasi penelitian ini adalah seluruh klien dengan TB paru di Puskesmas Sidosermo Surabaya yang menjalani pengobatan dengan besar sampel 22 klien diambil sampling insidental. Variabel bebas dalam penelitian ini adalah kepatuhan minum obat yang meliputi dosis, waktu dan aturan minum obat TB paru. Instrumen pengumpulan data menggunakan kuisioner dan rekam medis. Data yang telah diolah, disajikan dalam bentuk table atau distribusi frekuensi, dan dianalisis secara deskriptif. Hasil penelitian ini menunjukkan bahwa klien TB Paru yang menjalani pengobatan seluruhnya (100%) patuh dalam pemberian dosis obat, sebagian besar (63,64%) tidak patuh waktu minum obat dan hampir seluruhnya (81,81%) patuh dalam mengikuti aturan minum obat. Diharapkan klien TB paru yang menjalani pengobatan meningkatkan serta memperhatikan ketepatan waktu minum obat dan aturan minum obat
.
Kata Kunci : Kepatuhan, TB Paru, Pengobatan

COMPLIANCE WITH TAKING PULMONARY MEDICINE IN SIDOSERMO HEALTH CENTER OF SURABAYA
Pulmonary Tuberculosis (pulmonary TB) is a disease that has long been known and is still a health problem in various countries in the world. Treatment adherence is the key to eradicating and curing pulmonary TB. The purpose of this study was to determine the compliance of pulmonary TB clients in undergoing TB treatment. This type of research is descriptive which describes the adherence to taking medication in pulmonary TB clients undergoing treatment. The population of this study were all clients with pulmonary TB at the Sidosermo Health Center Surabaya who underwent treatment with a sample size of 22 clients taken incidental sampling. The independent variable in this study was medication adherence which included dose, time and the rules for taking pulmonary TB drugs. Data collection instruments used questionnaires and medical records. Data that has been processed, presented in the form of a table or frequency distribution, and analyzed descriptively. The results of this study indicate that pulmonary TB clients who undergo treatment are entirely (100%) obedient in administering drug doses, most (63.64%) are not compliant when taking medication and almost all (81.81%) are obedient in following the rules of taking medication. . It is hoped that pulmonary TB clients undergoing treatment will improve and pay attention to the timeliness of taking medication and the rules for taking medication.
Keywords : Drug adherence, TB, Treatment
KEPATUHAN OLAHRAGA PADA KLIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS PACAR KELING SURABAYA
Authors: Agnes Valencia Noviar  , Supriyanto  , Padoli Padoli 
Published: December 2023

ABSTRAK

Keberhasilan terapi pada klien diabetes melitus salah satunya ditentukan dari kepatuhan untuk melakukan olahraga. Tujuan penelitian ini untuk mengetahui kepatuhan olahraga pada klien diabetes melitus tipe 2. Penelitian ini menggunakan metode deskriptif. Populasi penelitian ini adalah klien diabetes melitus tipe 2 di Puskesmas Pacar Keling Surabaya, besar sampel 100 klien yang dipilih dengan teknik consecutive sampling. Variabel dalam penelitian ini adalah kepatuhan olahraga. Instrumen penelitian ini menggunakan kuesioner. Data yang terkumpul disajikan dalam table distribusi frekuensi dan dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa sebagian besar (61%) klien diabetes melitus tipe 2 tidak patuh melakukan olahraga. Diharapkan tenaga kesehatan khususnya perawat lebih intens dalam memberikan penyuluhan kesehatan mengenai pentingnya olahraga pada klien diabetes melitus. dan melibatkan keluarga dalam memberikan pelayanan keperawatan untuk meningkatkan kepatuhan olahraga klien.
Kata kunci : Kepatuhan, Olahraga, Diabetes Melitus Tipe 2

EXERCISE ADHERENCE IN TYPE 2 DIABETES MELLITUS CLIENTS IN PACAR KELING PUSKESMAS SURABAYA

ABSTRACT

The success of therapy in diabetes mellitus clients is determined by adherence to exercise. The purpose of this study was to determine exercise compliance in clients with type 2 diabetes mellitus. This study used a descriptive method. The population of this study were clients with type 2 diabetes mellitus at the Paddy Keling Public Health Center, Surabaya, with a sample size of 100 clients who were selected using a consecutive sampling technique. The variable in this study is exercise compliance. The instrument of this research used a questionnaire. The data collected is presented in a frequency distribution table and analyzed descriptively. The results showed that most (61%) clients with type 2 diabetes mellitus did not comply with exercise. It is expected that health workers, especially nurses, are more intense in providing health education about the importance of exercise for clients with diabetes mellitus. and involve the family in providing nursing services to improve the client's exercise compliance.
Keywords : Adherence, Exercise, Type 2 Diabetes Mellitus