bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Skeletal Stability of Mandibular Surgery with Bilateral Sagittal Split Ramus Osteotomy—Advancement Versus Setback: A Systematic Review and Meta-analysis
Authors: Jain Dhruv , Datana Sanjeev , Chopra Sukhbir Singh 
Published: October 2023

Objectives The aim of this study was to evaluate and compare the long-term skeletal stability of mandibular advancement and mandibular setback achieved with bilateral sagittal split ramus osteotomy (BSSRO) procedure in adult patients with a minimum follow-up of at least 1 year. Methods A literature search was systematically performed according to PRISMA guidelines from four databases without limitation till 15 June 2021. Available literature was assessed for long-term skeletal stability as horizontal/vertical changes at cephalometric point B following conventional mandibular surgery (BSSRO) with rigid internal fixation. The quality of selected articles was assessed using Newcastle–Ottawa scale and the meta-analysis was carried out with Q statistic method, I-squared statistics, and fixed-effect model to estimate the pooled mean and Begg–Mazumdar bias indicator. Results A total of five studies (three pertaining to mandibular advancement and two setback groups) were included for comparative evaluation of relapse. The mean horizontal relapse was 7.85% pertaining to mandibular advancement (4.2–7.06 mm) as compared to 27% pertaining to mandibular setback (7.18–10.26 mm). The meta-analysis of four included studies (two in each group) revealed significant differences in long-term skeletal stability of mandibular advancement and setback (pooled proportion = 20.10; 95% confidence interval = 2.48–39.57). Conclusion Mandibular setback can be expected to relapse by 21.7–32.3% (mean 27%) as compared to mandibular advancement accounting for a relapse of 2.1–15.4% (mean 7.85%) in adult patients. Hence, mandibular advancement is a relatively stable procedure in the long term. PROSPERO registration number: CRD42021261466
A First Exploration: Can Eye Movement Desensitization and Reprocessing Improve Cognition in Older Adults With Posttraumatic Stress Disorder?
Authors: Gielkens Ellen M. J. , Rossi Gina , van Alphen Sebastiaan P. J. , Sobczak Sjacko 
Published: October 2023

Objectives In older adults, PTSD is associated with decreased verbal learning and executive dysfunction. Therefore, feasibility of EMDR-treatment to improve cognitive performance in older adults with PTSD was examined. Additionally, we investigated pre-treatment correlation with often co-occurring risk factors for cognitive decline (sleep problems, depressive disorder, physical inactivity, childhood traumatic events). Design Multicenter design with pre-post measurements. Setting Psychiatric Dutch hospitals Mondriaan Mental Health Center and Altrecht. Participants 22 treatment-seeking PTSD-outpatients (60-84 years). Intervention Weekly one-hour EMDR session during 3, 6, or 9 months. Measurements PTSD was assessed with Clinician-Administered PTSD-scale for DSM-5 (CAPS-5). Verbal learning memory was measured with Auditory Verbal Learning Test (RAVLT), interference with Stroop Colour-Word Test (SCWT) and working memory with Wechsler Adult Intelligence Scale-Digit Span (WAIS-IV-DS). Results A Linear mixed-model showed significant improvement on RAVLT immediate-recall (F (1, 21) = 15.928, P = .001, 95% CI -6.98-2.20), delayed-recall (F (1, 21) = 7.095, P = .015, 95% CI -2.43-.30), recognition (F (21) = 8.885, P = .007, 95% CI -1.70– -.30), and SCWT (F (1 ,21) = 5.504, P = .029, 95% CI 4.38-72.78) but not on WAIS-IV-DS (F (20) = -1.237, P = .230, 95% CI -3.07-.78). There was no significant influence of therapy duration and CAPS-5 pre-treatment scores. There were small-medium nonsignificant correlations between CAPS-5 and cognitive performance pre-post differences, and between most cognitive measures and sleep problems, depressive disorder, and physical inactivity. Conclusions Cognitive functioning on memory and attention possible increased in older adults with PTSD after EMDR treatment. Further research is needed with a larger sample and a control condition to corroborate these findings and to identify the possible mediating role of modifiable risk factors.
The patients’ lived experiences with equitable nursing care
Authors: Bahador Raziyeh sadat , Dastyar Neda , Ahmadidarrehsima Sudabeh , Rafati Shideh , Rafati Foozieh 
Published: October 2023

Background Equitable care is a fundamental value in the nursing profession. Healthcare workers have both a moral and professional duty to ensure that they do not discriminate. Aim This study aimed to explore how patients perceive equitable nursing care. Research design, participants, and research context This descriptive phenomenological qualitative research study used purposeful sampling to select 17 patients from various departments of a general hospital in southern Iran. The participants were then interviewed using a semi-structured in-depth interview format, which aimed to delve into their experiences with equitable nursing care. The collected data were analyzed using Colaizzi's seven-step method and MAXQDA20 software. Ethical considerations Oral and written information about the study was provided before the participants gave their written consent. The transcribed interviews were de-identified. The study was approved by the Ethics Committee of Jiroft University of Medical Sciences. Findings The data analysis of the study identified three main themes and six subthemes that were related to the experiences of patients with equitable nursing care. The first theme, equitable care, encompassed subthemes such as nurses’ dedicated efforts to facilitate patient recovery and adherence to ethical behavior. The second theme, unconscious causes of inequitable nursing care, included subthemes such as unintentional discrimination stemming from organizational constraints and unconscious biases resulting from a lack of knowledge and skills. The third theme, discriminatory care, comprised subthemes such as deliberate discrimination based on personal traits and selective discrimination. Conclusion The study findings indicate that achieving equitable nursing care requires a multifaceted approach. This includes effective hospital management, organizational reforms, and regulatory enhancements. Additionally, it is crucial to pay close attention to the needs of patients, enhance nurses’ theoretical and practical skills in providing equitable care, fostering a culture of equality within healthcare settings, and consider the personality dimensions and moral characteristics of nurses.
Factors associated with better alcohol hand rub in 2020. Results from the French national audit “Pulpe’friction”
Authors: Ranger Mathilde , Dumartin Catherine , Nasso Raymond , Péfau Muriel , Parneix Pierre , Venier Anne-Gaëlle 
Published: October 2023

Background The application of alcohol-based hand rub on hands (ABHR) can prevent the transmission of microorganisms. But, in some situations the practices remain perfectible. Aim The aim of this study was to assess the self-reported ABHR practices of healthcare workers (HCWs) and to identify the factors associated with better ABHR compliance. Methods A cross-sectional study was conducted using the French national “Pulpe'friction” audit, from 1st January 2020 to 31st December 2020, in healthcare facilities and social welfare facilities in France. Data were analyzed using descriptive statistics and multivariate logistic regression models. Results Of the 6769 HCWs, the average ABHR compliance was 75% “before patient contact,” 95% “before an invasive technique,” 86% “after patient contact,” and 79% “after contact with patient surroundings.” The main reported barriers were the availability, the discomfort and the harmfulness of the product. The factors significantly associated with a better compliance were the individual importance given to hand hygiene (HH); working in a healthcare facility, except in the situation “before an invasive technique”; medical profession “after patient contact”; paramedical profession “after contact with patient surroundings.” Discussion These results call for national actions to fight the most reported barriers and raise awareness on the importance of HH, especially before touching the patient.
Self-concept in Adolescents with Physical-Mental Comorbidity
Authors: Ferro Mark A. , Dol Megan , Patte Karen A. , Leatherdale Scott T. , Shanahan Lilly 
Published: October 2023

Objective Little is known about self-concept in adolescents with physical-mental comorbidity. This study investigated whether physical-mental comorbidity was associated with self-concept in adolescents and examined if adolescent age or sex moderated the association between physical-mental comorbidity and self-concept. Methods Study data were obtained from the Multimorbidity in Youth across the Life-course (MY LIFE), an ongoing Canadian study of adolescents with chronic physical illness who were recruited from outpatient clinics at a pediatric hospital. A total of 116 adolescents aged ≥ 10 years provided self-reports on key measures. Results Adolescents with comorbidity (n = 48) had lower self-concept scores on the Self-Determination Questionnaire (SDQ; d = 0.62) and Self-Perception Profile for Children (SPPC; d = 0.53) vs. adolescents without comorbidity (n = 68). An age × comorbidity status interaction was found and age-stratified models were computed to investigate this moderating effect of age. Amongst older adolescents, comorbidity was associated with lower SDQ (B = -2.55, p < .001), but this association was not found among younger adolescents (B = -0.29, p = .680). A similar effect was found for SPPC among older (B = -0.48, p = .001) and younger adolescents (B = 0.03, p = .842). Adolescent sex was not found to be a moderator. Conclusions Physical-mental comorbidity in adolescence was associated with lower self-concept and this association was moderated by age—differences between adolescents with vs. without comorbidity were greater for older adolescents and were clinically relevant. Opportunities to support positive self-perceptions for adolescents with comorbidity are warranted, especially when planning the transition from pediatric to adult health services.
A study to assess the efficacy of enasidenib and risk-adapted addition of azacitidine in newly diagnosed IDH2-mutant AML
Authors: Cai Sheng F. , Huang Ying , Lance Jennie R. , Mao Hsiaoyin Charlene , Dunbar Andrew J. , McNulty Samantha N. , Druley Todd , Li Yan , Baer Maria R. , Stock Wendy , Kovacsovics Tibor , Blum William G. , Schiller Gary J. , Olin Rebecca L. , Foran James M. , Litzow Mark , Lin Tara , Patel Prapti , Foster Matthew C. , Boyiadzis Michael , Collins Robert H. , Chervin Jordan , Shoben Abigail , Vergilio Jo-Anne , Heerema Nyla A. , Rosenberg Leonard , Chen Timothy L. , Yocum Ashley O. , Druggan Franchesca , Marcus Sonja , Stefanos Mona , Druker Brian J. , Mims Alice S. , Borate Uma , Burd Amy , Byrd John C. , Levine Ross L. , Stein Eytan M. 
Published: October 2023

Abstract
Enasidenib (ENA) is an inhibitor of isocitrate dehydrogenase 2 (IDH2) approved for the treatment of patients with IDH2-mutant relapsed/refractory acute myeloid leukemia (AML). In this phase 2/1b Beat AML substudy, we applied a risk-adapted approach to assess the efficacy of ENA monotherapy for patients aged ≥60 years with newly diagnosed IDH2-mutant AML in whom genomic profiling demonstrated that mutant IDH2 was in the dominant leukemic clone. Patients for whom ENA monotherapy did not induce a complete remission (CR) or CR with incomplete blood count recovery (CRi) enrolled in a phase 1b cohort with the addition of azacitidine. The phase 2 portion assessing the overall response to ENA alone demonstrated efficacy, with a composite complete response (cCR) rate (CR/CRi) of 46% in 60 evaluable patients. Seventeen patients subsequently transitioned to phase 1b combination therapy, with a cCR rate of 41% and 1 dose-limiting toxicity. Correlative studies highlight mechanisms of clonal elimination with differentiation therapy as well as therapeutic resistance. This study demonstrates both efficacy of ENA monotherapy in the upfront setting and feasibility and applicability of a risk-adapted approach to the upfront treatment of IDH2-mutant AML. This trial is registered at www.clinicaltrials.gov as #NCT03013998.
Minimum factor VIII levels to prevent joint bleeding in mild hemophilia A
Authors: Agosti Pasquale , Siboni Simona Maria , Scardo Sara , Torri Adriana , Gualtierotti Roberta , Peyvandi Flora 
Published: October 2023

Abstract
The severity of the bleeding phenotype in patients with hemophilia A (HA) broadly correlates with the degree of coagulation factor VIII (FVIII) deficiency in plasma. However, the FVIII level necessary to achieve the goal of zero joint bleeds remains unclear. This study aimed to identify the minimum FVIII level necessary to prevent joint bleeds in patients with HA. In this retrospective study, patients with congenital mild HA treated on demand, aged ≥16 years, with no history of FVIII inhibitors, followed at the Angelo Bianchi Bonomi Hemophilia and Thrombosis Center in Milan, were enrolled. We investigated 270 male patients with a median age of 45 years (16-88) and median lifelong FVIII of 21 IU/dL. One hundred patients (37%) had a lifelong history of at least 1 joint bleed. The mean annualized joint bleeding rate (AJBR) and spontaneous AJBR were 0.016 (standard deviation [SD], 0.032) and 0.001 (SD, 0.010), respectively. After adjusting for age, for each IU/dL increase in FVIII, there was a 6% reduction in AJBR and an 11% reduction in spontaneous AJBR. The minimum FVIII levels needed to prevent lifelong any joint bleeds and spontaneous joint bleeds resulted to be 19.2 IU/dL and 17.7 IU/dL, respectively. In this large cohort of persons with mild HA, we identified the minimum FVIII levels needed to prevent total and spontaneous joint bleeds (19.2 IU/dL and 17.7 IU/dL, respectively). These findings could suggest important implications for the accurate design of prophylactic therapies for persons with moderate and severe HA, including gene therapy.
Improving Ultrasonic Testing by Using Machine Learning Framework Based on Model Interpretation Strategy
Authors: Shi Siqi , Jin Shijie , Zhang Donghui , Liao Jingyu , Fu Dongxin , Lin Li 
Published: October 2023

AbstractUltrasonic testing (UT) is increasingly combined with machine learning (ML) techniques for intelligently identifying damage. Extracting significant features from UT data is essential for efficient defect characterization. Moreover, the hidden physics behind ML is unexplained, reducing the generalization capability and versatility of ML methods in UT. In this paper, a generally applicable ML framework based on the model interpretation strategy is proposed to improve the detection accuracy and computational efficiency of UT. Firstly, multi-domain features are extracted from the UT signals with signal processing techniques to construct an initial feature space. Subsequently, a feature selection method based on model interpretable strategy (FS-MIS) is innovatively developed by integrating Shapley additive explanation (SHAP), filter method, embedded method and wrapper method. The most effective ML model and the optimal feature subset with better correlation to the target defects are determined self-adaptively. The proposed framework is validated by identifying and locating side-drilled holes (SDHs) with 0.5λ central distance and different depths. An ultrasonic array probe is adopted to acquire FMC datasets from several aluminum alloy specimens containing two SDHs by experiments. The optimal feature subset selected by FS-MIS is set as the input of the chosen ML model to train and predict the times of arrival (ToAs) of the scattered waves emitted by adjacent SDHs. The experimental results demonstrate that the relative errors of the predicted ToAs are all below 3.67% with an average error of 0.25%, significantly improving the time resolution of UT signals. On this basis, the predicted ToAs are assigned to the corresponding original signals for decoupling overlapped pulse-echoes and reconstructing high-resolution FMC datasets. The imaging resolution is enhanced to 0.5λ by implementing the total focusing method (TFM). The relative errors of hole depths and central distance are no more than 0.51% and 3.57%, respectively. Finally, the superior performance of the proposed FS-MIS is validated by comparing it with initial feature space and conventional dimensionality reduction techniques.
High energy density storage, antifungal activity and enhanced bioimaging by green self-doped heteroatom carbon dots
Authors: Sheikh Mohd Abdullah , Chandok R. S. , Abida Khan 
Published: October 2023

AbstractSelf-heteroatom-doped N-carbon dots (N-CDs) with a 2.35 eV energy gap and a 65.5% fluorescence quantum yield were created using a one-step, efficient, inexpensive, and environmentally friendly microwave irradiation method. FE-SEM, EDX, FT-IR, XRD, UV–VIS spectroscopy, FL spectroscopy, and CV electrochemical analysis were used to characterise the produced heteroatom-doped N-CDs. The graphitic carbon dot surface is doped with heteroatom functional groups such (S, P, K, Mg, Zn) = 1%, in addition to the additional passivating agent (N), according to the EDX surface morphology and the spontaneous heteroatom doping was caused by the heterogeneous chemical composition of pumpkin seeds. These spontaneous heteroatom-doped N-CDs possess quasispherical amorphous graphitic structure with an average size of less than 10 nm and the interplaner distance of 0.334 nm. Calculations utilising cyclic voltammetry showed that the heteroatom-doped N-CDs placed on nickel electrodes had a high specific capacitance value of 1044 F/g at a scan rate of 10 mV/s in 3 M of KOH electrolyte solution. Furthermore, it demonstrated a high energy and power density of 28.50 Wh/kg and 3350 W/kg, respectively. The higher value of specific capacitance and energy density were attributed to the fact that the Ni/CDs electrode material possesses both EDLC and PC properties due to the sufficient surface area and the multiple active sites of the prepared N-CDs. Furthermore, the heteroatom N-CDs revealed the antifungal action and bioimaging of the "Cladosporium cladosporioides" mould, which is mostly accountable for economic losses in agricultural products. The functional groups of nitrogen, sulphur, phosphorus, and zinc on the surface of the CDs have strong antibacterial and antifungal properties as well as fluorescence enhanced bioimaging.
Physiological and transcriptomic analysis reveals the potential mechanism of Morinda officinalis How in response to freezing stress
Authors: Luo Zhenhua , Che Xiaoying , Han Panpan , Chen Zien , Chen Zeyu , Chen Jinfang , Xiang Sishi , Ding Ping 
Published: October 2023

Abstract
Background
Morinda officinalis How (MO) is a vine shrub distributed in tropical and subtropical regions, known as one of the “Four Southern Herbal Medicines” in China. The unclear responsive mechanism by which MO adapt to freezing stress limits progress in molecular breeding for MO freezing tolerance.

Results
In this study, morphological, physiological and microstructure changes in MO exposed to -2℃ for 0 h, 3 h, 8 h and 24 h were comprehensively characterized. The results showed that freezing stress caused seedling dehydration, palisade cell and spongy mesophyll destruction. A significant increase in the content of proline, soluble protein and soluble sugars, as well as the activity of superoxide dismutase and peroxidase was observed. Subsequently, we analyzed the transcriptomic changes of MO leaves at different times under freezing treatment by RNA-seq. A total of 24,498 unigenes were annotated and 3252 unigenes were identified as differentially expressed genes (DEGs). Most of these DEGs were annotated in starch and sucrose metabolism, plant hormone signal transduction and MAPK signaling pathways. Family Enrichment analysis showed that the glucosyl/glucuronosyl transferases, oxidoreductase, chlorophyll a/b binding protein and calcium binding protein families were significantly enriched. We also characterized 7 types of transcription factors responding to freezing stress, among which the most abundant family was the MYBs, followed by the AP2/ERFs and NACs. Furthermore, 10 DEGs were selected for qRT-PCR analysis, which validated the reliability and accuracy of RNA-seq data.

Conclusions
Our results provide an overall view of the dynamic changes in physiology and insight into the molecular regulation mechanisms of MO in response to freezing stress. This study will lay a foundation for freezing tolerance molecular breeding and improving the quality of MO.
Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population
Authors: Kadier Kaisaierjiang , Dilixiati Diliyaer , Ainiwaer Aikeliyaer , Liu Xiaozhu , Lu Jiande , Liu Pengfei , Ainiwan Mierxiati , Yesitayi Gulinazi , Ma Xiang , Ma Yitong 
Published: October 2023

Abstract
Background
The association between sleep-related disorders and inflammation has been demonstrated in previous studies. The systemic immune-inflammation index (SII) is a novel inflammatory index based on leukocytes, but its relationship with sleep-related disorder is unclear. We aimed to investigate the relationship between sleep-related disorder and SII in a nationally representative nonhospitalized sample.

Methods
Data were obtained from the 2005–2008 National Health and Nutrition Examination Survey (NHANES). Exposure variables included self-reported sleep-related disorders, such as sleep duration, sleep problems, high risk of OSA, and daytime sleepiness. SII and other traditional markers of inflammation were considered as outcome variables, including platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). Multiple linear regression models were employed to examine the correlation between sleep-related disorders and inflammatory markers. Subgroup interactions were analyzed using likelihood ratio tests, and nonlinear relationships were explored by fitting restricted cubic splines.

Results
A total of 8,505 participants were enrolled in this study. Overall, sleep-related disorders were found to have a stronger association with SII compared to the PLR and NLR. The results of multiple linear regression analysis revealed that participants who experienced sleep problems (β: 21.421; 95% CI 1.484, 41.358), had symptoms of OSA (β: 23.088; 95% CI 0.441, 45.735), and reported daytime sleepiness (β: 30.320; 95% CI 5.851, 54.789) exhibited a positive association with higher SII. For the analysis of other inflammatory markers, we only found that daytime sleepiness was associated with increased NLR levels (β: 0.081; 95% CI 0.002, 0.159).

Conclusion
Sleep problems, symptoms of OSA, and daytime sleepiness were found to have a positive association with the SII in US adults. However, further prospective studies are necessary to establish whether there is a causal relationship between these factors.