bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upper gastrointestinal involvement of Behçet's disease in Japan: endoscopic findings and clinical features
Authors: Murakami Keita , Arai Junya , Ihara Sozaburo , Tsuchida Yumi , Shoda Hirofumi , Tsuboi Mayo , Kurokawa Ken , Shiomi Chihiro , Suzuki Nobumi , Hayakawa Yoku , Fujio Keishi , Fujishiro Mitsuhiro 
Published: January 2024

AbstractAimBehçet's disease (BD) can involve any gastrointestinal (GI) tract site. We analyzed the characteristics, risk factors, and treatment responses to upper GI (UGI) involvement in patients with BD.MethodsThis retrospective cohort study analyzed UGI findings in 101 patients with BD who underwent endoscopy between April 2005 and December 2022 at the University of Tokyo Hospital. The patients were divided into two groups based on the presence or absence of UGI findings. Patient backgrounds, clinical symptoms, colonoscopy (CS) findings, and blood test findings were compared between the groups.ResultsIn total, 18.8% (19/101) of the patients had UGI lesions. The prevalence rates in the esophagus, stomach, and duodenum were 6.9%, 6.9%, and 8.9%, respectively. Of these 19 patients, BD treatment were intensified in 10 (52.6%) patients after esophagogastroduodenoscopy (EGD), and all showed improvement in symptoms or endoscopic findings. In the multivariate analysis, symptoms (OR: 37.1, P < 0.001), CRP > 1 mg/dL (OR: 11.0, P = 0.01), and CS findings (OR: 5.16, P = 0.04) were independent predictors of UGI involvement in BD patients. The prediction model for UGI involvement using these three factors was highly accurate, with an AUC of 0.899 on the ROC curve. In the subgroup analysis of intestinal BD, symptoms (OR: 12.8, P = 0.01) and ESR > 20 mm/h (OR: 11.5, P = 0.007) were independent predictors.ConclusionsEGD should be conducted in BD patients with high CRP, GI symptoms, and lower GI involvement, which leads to better management of BD in terms of improving symptoms and endoscopic findings.
Long‐term cognitive outcome after elective hip or knee total joint arthroplasty: A population‐based observational study
Authors: Tang Angelina B. , Diaz‐Ramirez L. Grisell , Boscardin W. John , Smith Alexander K. , Ward Derek , Glymour M. Maria , Whitlock Elizabeth L. 
Published: January 2024

AbstractBackgroundOne year after elective hip or knee total joint arthroplasty (TJA), >30% of older adults meet criteria for postoperative neurocognitive disorder. However, this is not contextualized with long‐term cognitive outcomes in comparable surgical and nonsurgical controls. We analyzed population‐based data to compare long‐term cognitive outcomes in older adults after TJA, other surgeries, and with and without arthritis pain.MethodsThis was a retrospective observational analysis of United States older adults in the Health and Retirement Study (HRS) who underwent elective TJA, or elective surgery without expected functional benefits (e.g., cholecystectomy; inguinal herniorrhaphy), between 1998 and 2018 at aged 65 or older. TJA recipients were also age‐ and sex‐matched to nonsurgical controls who reported moderate–severe arthritic pain or denied pain, so that comparison groups included surgical and nonsurgical (pain‐suffering and pain‐free) controls. We modeled biennially‐assessed memory performance, a measure of direct and proxy cognitive assessments, before and after surgery, normalized to the rate of memory decline (“cognitive aging”) in controls to express effect size estimates as excess, or fewer, months of memory decline. We used linear mixed effects models adjusted for preoperative health and demographic factors, including frailty, flexibly capturing time before/after surgery (knots at −4, 0, 8 years; discontinuity at surgery).ResultsThere were 1947 TJA recipients (average age 74; 63% women; 1358 knee, 589 hip) and 1631 surgical controls (average age 76; 38% women). Memory decline 3 years after TJA was similar to surgical controls (5.2 [95% confidence interval, CI −1.2 to 11.5] months less memory decline in the TJA group, p = 0.11) and nonsurgical controls. At 5 years, TJA recipients experienced 5.0 [95% CI −0.9 to 10.9] months less memory decline than arthritic pain nonsurgical controls.ConclusionThere is no systematic accelerated memory decline at 3 years after TJA compared with surgical or nonsurgical controls.
Pragmatic patchwork ethnography, a call to action for health, nutrition and dietetic researchers
Authors: Swettenham Marie , Langley‐Evans Simon C. 
Published: January 2024

AbstractQualitative research methods are increasingly used in nutrition and dietetics research. Ethnography is an underexploited approach which seeks to explore the diversity of people and cultures in a given setting, providing a better understanding of the influences that determine their choices and behaviours. It is argued that traditional ethnography, that is, the methodology of living within participant communities, is a dated practice, with roots in colonialism, accessible to only researchers with the means, connections and status to conduct such research, typically white, privileged males. This paper proposes a formal interpretation of ‘patchwork ethnography’, whereby research is carried out in situ around existing modern‐day commitments of the researcher, thus enabling more researchers within health, nutrition and dietetic practice to benefit from the rich data that can be discovered from communities. This review proposes the concept that pragmatic patchwork ethnography is required, proposing a framework for implementation, providing researchers, particularly within the fields of human nutrition, dietetics and health, the accessibility and means to deploy a meaningful client‐centric methodology. We present pragmatic patchwork ethnography as a modern method for use within multiple healthcare settings, thus adding a progressive brick in the wall of qualitative research.
Region‐specific interobserver agreement of the Alberta Stroke Program Early Computed Tomography Score: A meta‐analysis
Authors: Zarrintan Armin , Ibrahim Mohamed K. , Hamouda Noha , Jabal Mohamed Sobhi , Beizavi Zahra , Ghozy Sherief , Kallmes David F. 
Published: January 2024

AbstractBackground and PurposeThe Alberta Stroke Program Early CT Score (ASPECTS) is a widely used scoring system for evaluating ischemic stroke to determine therapeutic strategy. However, there is variation in the interobserver agreement of ASPECTS. This systematic review and meta‐analysis aimed to investigate the interobserver agreement of total and regional ASPECTS.MethodsA comprehensive search was conducted in the Web of Sciences, PubMed, and Scopus databases to identify relevant studies. Inclusion criteria were studies of noncontrast CT performed within 24 hours of ischemic stroke in the middle cerebral artery territory.ResultsA total of 20 studies, with 3482 patients, reporting interobserver agreement of total and regional ASPECTS were included in the meta‐analysis. The interobserver agreement for total ASPECTS in studies using Kappa coefficient (κ) analysis was substantial (κ = .67, 95% confidence interval [CI]: .57‐.78). In studies using intraclass correlation coefficient (ICC) analysis, agreement was excellent (ICC = .84, 95% CI: .77‐.90). Interobserver agreement was higher in studies in which the observer was unblinded to clinical scenario in both groups (κ = .74, 95% CI: .59‐.89, and ICC = .82, 95% CI: .79‐.85). Per‐region analysis showed that the caudate nucleus had the highest agreement (κ = .68, 95% CI: .60‐.76, and ICC = .84, 95% CI: .74‐.93), while M2 and internal capsule in Kappa studies (κ = .45, 95% CI: .34‐.55 and κ = .47, 95% CI: .28‐.66), and M4 and internal capsule in ICC studies (ICC = .54, 95% CI: .43‐.64 and ICC = .55, 95% CI: .18‐.91) had the lowest agreement.ConclusionThis meta‐analysis demonstrates substantial to excellent interobserver agreement for total ASPECTS, which supports using this method for stroke treatment. However, findings emphasize the need to consider interobserver agreement in specific regions of ASPECTS for treatment decisions.
Comparison of diagnostic methods for detection of BRAFV600E mutation in ameloblastoma
Authors: Anbinselvam Arularasan , Akinshipo Abdul‐Warith O. , Adisa Akinyele O. , Effiom Olajumoke A. , Zhu Xinhe , Adebiyi Kehinde E. , Arotiba Godwin T. , Akintoye Sunday O. 
Published: January 2024

AbstractBackgroundAmeloblastoma is an aggressively growing, highly recurrent odontogenic jaw tumor. Its association with BRAFV600E mutation is an indication for BRAFV00E‐inhibitor therapy The study objective was to identify a sensitive low‐cost test for BRAFV600E‐positive ameloblastoma. We hypothesized that immunohistochemical staining of formalin‐fixed paraffin‐embedded tissues for BRAFV600E mutation is a low‐cost surrogate for BRAFV600E gene sequencing when laboratory resources are inadequate for molecular testing.MethodsTissues from 40 ameloblastoma samples were retrieved from either formalin‐fixed paraffin‐embedded blocks, RNAlater™ stabilization solution or samples inadvertently pre‐fixed in formalin before transfer to RNAlater™. BRAFV600E mutation was assessed by Direct Sanger sequencing, Amplification Refractory Mutation System‐PCR and immunohistochemistry (IHC).ResultsBRAFV600E mutation was detected by IHC, Amplification Refractory Mutation System‐PCR and Direct Sanger sequencing in 93.33%, 52.5% and 30% of samples respectively. Considering Direct Sanger sequencing as standard BRAFV600E detection method, there was significant difference between the three detection methods (𝜒2 (2) = 31.34, p < 0.0001). Sensitivity and specificity of IHC were 0.8 (95% CI: 0.64–0.90) and 0.9 (95% CI: 0.75–0.99) respectively, while positive predictive value and negative predictive value (NPV) were 0.9 and 0.8 (Fischer's test, p < 0.0001) respectively. Sensitivity and specificity of Amplification Refractory Mutation System‐PCR detection method were 0.7 (95% CI: 0.53–0.80) and 0.9 (95% CI = 0.67–0.98) respectively, while PPV and NPV were 0.9 and 0.6 respectively (Fischer's test, p < 0.0001).ConclusionLow‐cost and less vulnerability of IHC to tissue quality make it a viable surrogate test for BRAFV600E detection in ameloblastoma. Sequential dual IHC and molecular testing for BRAFV600E will reduce equivocal results that could exclude some patients from BRAFV600E‐inhibitor therapies.
Enrofloxacin pharmacokinetics in yellow catfish (Pelteobagrus fulvidraco): A comparative analysis of oral, intramuscular, and bath administration
Authors: Jia Bofan , Zhao Yang , Deng Jianchao , Chen Shengjun , Li Chunsheng , Qi Bo , Hu Xiao , Li Laihao 
Published: January 2024

AbstractEnrofloxacin (ENR) residues in yellow catfish (Pelteobagrus fulvidraco) often exceed the standard due to excessive use. This study explored the pharmacokinetics of ENR and its metabolite ciprofloxacin (CIP) in yellow catfish following a single dose of 10 mg/kg body weight via intramuscular injection (IM), oral gavage (PO), or a 5‐h drug bath at 10 mg/L and 25°C. High‐performance liquid chromatography‐mass spectrometry was used to determine the ENR and CIP concentrations in various tissues. The highest ENR concentration occurred with IM administration, peaking at 4.124 mg/L in the plasma, 8.359 mg/kg in the kidney, 6.272 mg/kg in the liver, and 5.192 mg/kg in the muscle. However, PO administration resulted in the longest metabolic time, with elimination half‐lives of 56.47 h in plasma, 86.43 h in the kidney, 76.25 h in the liver, and 64.75 h in muscle. Additionally, the area under the concentration–time curve values for IM, PO, and bath administration in yellow catfish plasma were 108.36, 88.96, and 22.08 mg·h/L, respectively. These results indicate the effectiveness of all three administration methods in treating bacterial diseases in yellow catfish. The selection of an appropriate administration method depends on the minimal inhibitory concentration of ENR against pathogenic bacteria. Yellow catfish subjected to PO and IM administration require longer resting periods before they can be marketed than those receiving drug bath administration.
Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)
Authors: Ahmadifar Ehsan , Shohreh Poulin , Kalhor Naser , Shahriari Moghadam Mohsen , Yilmaz Sevdan , Mohammadzadeh Sedigheh , Khajeh Mostafa , Abarghouei Safoura 
Published: January 2024

AbstractThis trial was performed in order to investigate the response of zebrafish (Danio rerio) to dietary exposure to polystyrene nanoplastics (PS‐NPs) under laboratory conditions on fish growth and health. Healthy zebrafish (n=240) were divided into 12 tanks and fed with diets including 0 (T0), 100 (T1), 500 (T2), and 1000 (T3) mg kg−1 synthesized polystyrenes nanoplastics (PS‐NPs) for 30 days. At the end of trial, fish fed the PS‐NPs supplementation showed weight gain percentages of 79.45%, 70.35%, and 61.88% for T1, T2, and T3 groups, respectively, compared with 87.39% in the control fish. The SOD, GPX and MDA activities and cortisol levels increased by 47%, 32% and 35% and 46%, respectively, especially at high‐dose administration (p < 0.05). The expression of GPX (T2‐81% and T3‐82%) and SOD (T2‐101% and T3‐187%) were remarkably upregulated in T2 and T3 groups. Moreover, the relative gene expression of HSP70, interleukin‐1 (IL1), Interferon γ (IFN‐γ) and tumor necrosis factor‐α (TNF‐α) increased by 178%, 202%, 154% and 307%, respectively, especially at high‐dose administration (p < 0.05). The results of the present study demonstrated that exposure to PS‐NPs especially at high concentrations (500 and 1000 mg kg−1 of diet) negatively influenced growth, health status‐, antioxidant‐, and immunity‐related gene expression responses of zebrafish.
Comparison of the eggshell mammillary microstructure of Galliformes and Anseriformes
Authors: Rosenberger Joanna , Pytlak Kamil 
Published: January 2024

AbstractIn free‐living species, the comparison of eggshell microstructure focus mainly on species representing extremely different reproductive strategies or with phylogenetically divergent taxa. The purpose of this study was to compare the microstructure of the mammillary layer in two bird orders (Galliformes and Anseriformes) representing phylogenetically close precocials, and to relate eggshell microstructure to female body weight and egg characteristics. The results showed significant differences between the studied orders. The mammillary layer in Galliformes had more knobs, and consequently, the percent coverage with them was higher than in Anseriformes. The size of individual knobs did not differ significantly between the orders. The obtained results are consistent with the reports that the ossification at the time of hatching is more advanced in Galliformes, so representatives of this order must resorb more calcium from the eggshell. Egg parameters and female body weight were correlated significantly negatively only with the number of knobs per mm2 for Anseriformes and, to a lesser extent, for Galliformes, but not with the coverage per cent of knobs or the size of individual knobs. Only for the three largest species, which lay proportionally larger eggs than the other species studied, the number of knobs per mm2 was significantly lower, but no difference was found in the per cent coverage of knobs. Our results showed that order was a stronger predictor of microstructure than species. Different ossification patterns of the embryonic skeletal system described in these two orders could be the explanation for the observed differences in eggshell microstructure; however, more research is needed.
Economic decline, ethnonationalism and civil war onset
Authors: Scarcelli Marc 
Published: January 2024

AbstractWithin the scholarship on the causes of civil wars, GDP per capita represents a strong and robust variable. Less attention, however, is paid to the role of economic decline. When it is included at all, scholars tend to consider it only in the period just prior to the onset of war. This paper argues that the impact of economic decline has been underestimated, for in addition to its short‐term effects, evidence from case studies reveals that a particular pattern is often evident during periods of sharp economic decline, in which ethnonationalist actors ascend in political power while scapegoating minority populations. The resulting increase in interethnic tensions raises the risk of large‐scale civil violence even many years after a major recession. The cases of Yugoslavia, Ivory Coast and India show the long‐term effects of a common exogenous shock‐ the global recession of the late 1970s‐ in the form of rising ethnonationalist political actors, setting the stage for large‐scale interethnic civil violence long after the initial economic shock.
Corticosteroid in IgA nephropathy with moderate proteinuria: A retrospective cohort study
Authors: Wang Yu , Yu Jianwen , Jiang Yu , Li Jianbo , Yimamuyushan Aikeda , Xia Xi , Fan Li , Huang Fengxian , Chen Wei , Liu Qinghua 
Published: January 2024

AbstractBackgroundCorticosteroids remain contentious as a therapeutic option for IgA nephropathy. We conducted a retrospective cohort study to explore whether corticosteroid therapy is efficient and safe for IgAN patients with moderate proteinuria.MethodsA total of 336 patients with renal biopsy‐confirmed IgAN, estimated glomerular filtration (eGFR) over 15 mL/min/1.73 m2 and urine protein levels of 0.75–3.5 g/d were enrolled. According to the treatment protocol, we classified the enrolled patients into two groups: one receiving corticosteroids and the other receiving supportive care. Complete remission, partial remission, and no remission were applied to describe the efficacy assessments. The endpoint was defined as a 40% reduction in eGFR, the onset of ESRD, or renal disease‐related death.ResultsClinical and pathological progression risk factors were higher in corticosteroid‐treated individuals. Logistic regression analysis revealed that the corticosteroid group was considerably related to a higher remission rate after adjustment for confounding factors. The occurrence of serious adverse events between the two groups was not found to be statistically significantly different. Then, we matched 95 couples of patients with similar baseline levels in both groups by propensity score matching. The results showed that corticosteroid‐treated patients showed higher overall and complete remission rates than untreated patients. However, due to the relatively short follow‐up period, no significant differences in the incidence of endpoint and survival analyses have been observed thus far.ConclusionCorticosteroid therapy may benefit IgAN patients with moderate proteinuria via proteinuria reduction and renal function preservation.image
Practicalities of promoting practice‐based learning in end of life care for care home staff: Lessons from “online” supportive conversations and reflection sessions
Authors: Hockley Jo , Watson Julie , Johnston Lucy , Shenkin Susan D. 
Published: January 2024

AbstractIntroductionDeaths in care homes and “at home” are anticipated to account for a third of UK deaths by 2040. Currently, palliative and end of life care are not part of statutory training in care homes. Reflective practice is a tool that can facilitate practice‐based learning and support. Following a feasibly study to test “online” supportive conversations and reflection sessions (OSCaRS) to support care home staff in relation to death/dying during the first months of the COVID pandemic, a one‐year practice development follow‐up project was undertaken with the aim to create a team of NHS/specialist palliative care (SPC)‐based facilitators to lead and support OSCaRS provision in up to 50 care homes in one region in Scotland—the focus of this paper.MethodsForty care home managers attended an on‐line session explaining the project, with a similar session held for 19 NHS/SPC‐based nurses external to care homes. Those interested in facilitating OSCaRS then attended three education sessions. Data collected: records of all activities; reflective notes on OSCaRS organised/delivered; a summary of each OSCaRS reflection/learning points; final interviews with NHS/SPC trainee facilitators.ResultsA total of 19 NHS/SPC facilitators delivered one or more OSCaRS in 22 participating care homes. However, as of January 2022 only six trained facilitators remained active. Out of the 158 OSCaRS arranged, 96 took place with a total of 262 staff attending. There were three important aspects that emerged: the role, remit, and resources of NHS/SPC supporting OSCaRS; requirements within care homes for establishing OSCaRS; and, the practice‐based learning topics discussed at each OSCaRS.ConclusionAttempts to establish a team of NHS/SPC facilitators to lead OSCaRS highlights that end of life care education in care homes does not clearly fall within the contractual remit of either group or risks being missed due to more pressing priorities.
Deep vein thrombosis and bilateral submassive pulmonary emboli post‐routine sinus lift: A case report and review of the literature
Authors: Kim Danny H. , Zhao Eric J. , Tong Nicholas , Yang David H. 
Published: January 2024

AbstractVenous thromboembolism (VTE) arising after major oral surgery under general anaesthesia is an exceedingly rare occurrence, and under local anaesthesia even more so. We report a case of a 55‐year‐old male with a remote history of squamous cell carcinoma of the left tonsil, in remission, who developed deep vein thrombosis and bilateral pulmonary emboli after routine sinus lift under local anaesthetic. We discuss the diagnosis, risk factors, and the role of sinus lift in contributing to the onset of VTE in this report. We also discuss a role of potential thromboembolic prophylaxis in high‐risk patients undergoing dentoalveolar procedures under local anaesthetic.
Pay Attention to the Osteochondromas in Fibrodysplasia Ossificans Progressiva
Authors: Li Longqing , Lu Minxun , He Xuanhong , Zou Chang , Zheng Chuanxi , Wang Yitian , Tang Fan , Luo Yi , Zhou Yong , Min Li , Tu Chongqi 
Published: January 2024

BackgroundFibrodysplasia ossificans progressiva (FOP) is an extremely rare disease characterized by malformation of the bilateral great toes and progressive heterotopic ossification. The clinical features of FOP occur due to dysfunction of the bone morphogenetic protein (BMP) signaling pathway induced by the mutant activin A type I receptor/activin‐like kinase‐2 (ACVR1/ALK2) which contributes to the clinical features in FOP. Dysregulation of the BMP signaling pathway causes the development of osteochondroma. Poor awareness of the association between FOP and osteochondromas always results in misdiagnosis and unnecessary invasive operation.Case PresentationIn this study, we present a case of classical FOP involving osteochondroma. An 18‐year‐old male adolescent, born with deformity of bilateral big toes, complained multiple masses on his back for 1 year. The mass initially emerged with a tough texture and did not cause pain. It was misdiagnosed as an osteochondroma. After two surgeries, the masses became hard and spread around the entire back region. Meanwhile, extensive heterotopic ossification was observed around the back, neck, hip, knee, ribs, and mandible during follow‐up. Osteochondromas were observed around the bilateral knees. No abnormalities were observed in the laboratory blood test results. Whole exome sequencing revealed missense mutation of ACVR1/ALK2 (c.617G > A; p.R206H) in the patient and confirmed the diagnosis of FOP.ConclusionIn summary, classical FOP always behaves as a bilateral deformity of the big toes, as well as progressive ectopic ossification and osteochondromas in the distal femur and proximal tibia. An understanding of the association between osteochondromas and FOP aids in diagnosis and avoids unnecessary invasive management in patients.