bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haplotype‐based noninvasive prenatal diagnosis of methylmalonic acidemia and the discovery of a recurrent pathogenic haplotype associated with c.609G>A
Authors: Fu Xinyu , Li Shaojun , Zhao Zhenhua , Kong Lingrong , Zhu Jingqi , Li Huanyun , Feng Jun , Tang Weiqin , Wu Di , Kong Xiangdong 
Published: November 2023

AbstractBackgroundEarly diagnosis and intervention are crucial for the prognosis of methylmalonic acidemia (MMA). However, research focused on early prenatal diagnosis of MMA is limited.MethodsA 161.89kb capture panel was designed for selectively enriching highly heterozygous SNPs. Fetal genotypes were inferred using relative haplotype dosage (RHDO) and Bayes factor, followed by invasive prenatal diagnosis (IPD) for validation. A core pathogenic haplotype associated with c.609G>A was identified based on the frequency differences between pathogenic and normal haplotypes.ResultsWe recruited 41 pregnancies at risk of MMA with a median gestational age of 8+2 weeks. The assay success rate of NIPD‐MMA for maternal variants was 92.7% (38/41), and after incorporating the paternal result, the overall assay success rate reached 100% (41/41). All NIPD results were concordant with IPD. Notably, a core haplotype (hap_2), comprising 28 SNPs, demonstrates significant enrichment within pathogenic haplotypes bearing the c.609G>A variation. On average, c.609G>A carriers had 22.38 heterozygous loci within these 28 SNPs.ConclusionNIPD‐MMA presents a viable choice for early, accurate, and safe prenatal diagnosis. Furthermore, the discovery of the recurrent core pathogenic haplotype provides a novel approach for haplotype phasing and has the potential for realizing proband‐independent NIPD in the future.
Collagen materials with oriented structure for biomedical applications
Authors: Zeng Rui , Tang Keyong , Tian Huafeng , Pei Ying 
Published: November 2023

AbstractAs one of the most critical natural structural proteins in tissues, collagen provides a degree of stiffness and rigidity to some of the liquid components of living organisms. Highly oriented materials composed of uniformly arranged collagen play a crucial role in determining the mechanical properties, physiological and biochemical functions of the matrix. Collagen materials with oriented structures promote and support cell migration and proliferation to achieve physiological structure and function. This review outlines the multilayered structure of collagen. It summarizes recent strategies and methods for constructing oriented collagen materials, including mechanical forces, external field effects, template assist, and biomedical applications of oriented collagen. Finally, we present potential challenges and prospects for developing oriented collagen materials.
Significant opportunities for tree crop expansion on marginal lands in the Midwest, USA
Authors: Thapa Bhuwan , Lovell Sarah , Revord Ronald , Owens Phillip , Gold Michael , Meier Nicholas 
Published: November 2023

AbstractIntroductionTree crop orchards can help diversify the monocropping practices in agricultural lands such as the Midwestern region of the United States which is currently dominated by corn‐soybean rotation. These crops can not only expand farm income but also help stabilize soil, purify water, and provide other ecosystem services. Despite these benefits, tree crops as agroforestry systems are not widely established in the region. Identifying marginal land that is more suitable for tree crops over row crops can help the growers and the environment.Materials and MethodsUsing the case of Missouri, USA, this study mapped marginal land for nut‐producing tree crops using a three‐step process. The first step includes the identification of marginal land suitable for a wide variety of tree crops. The second step involved GIS‐based multicriteria analysis of biophysically suitable areas for three commercially viable tree species, that is, eastern black walnut, pecan, and Chinese chestnut. The final step maps the marginal land for tree crops based on their suitability to grow under different environmental vulnerabilities, mainly flooding, erosion, and sloped conditions. The Gridded Soil Survey Geographic Database developed by the United States Department of Agriculture provided information on soil biophysical and environmental characteristics.ResultsThe spatial analysis showed that Missouri has around 16,000 sq. km of land suitable for Black walnut, followed by 10,801 sq. km and 4587 sq. km for pecan and Chinese chestnut, respectively. The study found very few tree crop orchards on these marginal lands.ConclusionThere are ample opportunities to expand tree crops on marginal cropland. Converting these lands to tree crops could provide communities with economic, human health, and environmental benefits. This multistep methodology could serve as a screening tool to identify tree‐cropping areas for environmental improvement and rural America's economic revitalization.
Convergence innovation for sustainable development: Unraveling post‐COVID dynamics for a resilient future
Authors: Ali Jamshed 
Published: November 2023

AbstractThis paper explores the potential of Convergence Innovation (CI) as an effective catalyst for dealing with the COVID‐19 pandemic and devising a trajectory toward a sustainable post‐crisis future. It offers novel perspectives on sustainable innovation approaches that can enhance organizational performance and extend beyond it. The paper makes significant contributions to both the theoretical and practical aspects of innovation. It illustrates the impact of market forces in the context of the Fourth Industrial Revolution (4IR) and Digital Technologies (DT), highlighting the significance of sustainable innovation for organizational prosperity and individual welfare. Convergence Innovation is explained as a self‐regulating ecosystem that promotes and goes beyond value creation. Different technologies in the ecosystem enhance CI's sensing capabilities for fluctuations in market forces and facilitate the transmission of data for decision‐making. The study recommends splitting off the S‐curve of innovation and the life cycle of competitive intelligence, as the S‐curve of CI tends to be shorter in the digital age. This paper provides managers with a new framework for thinking about innovation and its role in achieving sustainable business success. By embracing CI, managers can create more agile and adaptable organizations that are better positioned to navigate the complex and rapidly changing world of the digital age.
Degradation of synthetic azo dyes by Citrobacter freundii isolated from tannery effluent
Authors: Manikandan K  , Lavanya S  , Ranjani S  , Begum Faridha , Hemalatha S  
Published: November 2023

AbstractScarcity of water is becoming a big issue. Most of the water is used in industrial sectors including pharmaceutical, food, textiles, leather, and cosmetics. Industrial effluent water is unable to treat and reuse due to their intricate nature. Effluent water contains synthetic azo dyes since they employ synthetic azo dyes as a major coloring agent. Existing approaches are ineffective in treating effluent containing synthetic azo dyes. Synthetic azo dyes containing effluent water can be treated biologically to overcome the drawbacks of physical and chemical processes. In this research work, novel organism was isolated from tannery effluent water. Isolated organisms were screened and selected for effective degradation of azo dyes. One such organism is Citrobacter freundii which effectively degrade the effluent water containing synthetic azo dyes and allowing it to reuse for variety of purpose. Phytotoxicity study of the treated water was carried out and the study confirms non toxicity nature of the treated water. In‐silico screening was carried out to test the interaction efficacy of enzymes such as Laccase, Azo reductase, and peroxidase which are responsible for effective dye degradation with synthetic azo dyes. In silico studies showed better interactions between synthetic azo dyes and enzymes. This is the novel report on showing the effective degradation of synthetic azo yellow dye by using C. freundii isolated from tannery effluent.
Armed Conflict Increases Elephant Poaching
Authors: Englander Gabriel 
Published: November 2023

AbstractPoaching is the greatest threat to the survival of elephants and many other commercially valuable species. There are many hypothesized drivers of wildlife poaching, but few empirical estimates of their causal effects on poaching levels. In this chapter, I provide the first causal estimates of a spatially varying driver of wildlife poaching. Using elephant poaching and armed conflict data spanning 13 years and 77 sites in 39 countries across Africa and Asia, I find that the onset of a new conflict near elephant populations significantly increases contemporaneous elephant poaching levels by 12–22%. I leverage a variety of econometric methods to show that these estimates are plausibly causal and robust to alternative specifications and different measures of conflict and poaching. I estimate that conflict accounts for the illegal killing of 80,000 elephants between 2002 and 2014. To protect elephants, governments and NGOs should increase support to affected areas when conflicts begin.
So You Want To Be Relevant: A Policy Analyst’s Reflections on Academic Literature
Authors: Helfand Gloria 
Published: November 2023

AbstractOf course (many of) you in academia want your work to be relevant, to serve a purpose beyond its immediate role in academic promotion and prestige. Research can get public attention, when it feeds into a current public debate, and can influence policy decisions and potentially shape the future. Funding sources often request information on the policy implications of proposed research. Contributing to public policy can be personally satisfying, career-enhancing, and maybe even welfare-improving.
Peter Berck’s Contributions to Forestry Economics
Authors: Templeton Scott R. , Gilless J. Keith 
Published: November 2023

AbstractPeter Berck published numerous articles and book chapters related to the economics of forestry. His research covered, in approximate chronological order, four areas within forestry economics: (1) actual and optimal harvesting of timber, demand for timber, and, more generally, markets for wood products; (2) economic aspects of integrated management of forest pests; (3) old-growth redwoods, as a nonrenewable resource, and (4) impacts of timber harvesting and other aspects of forestry on income and employment in nearby communities. Interwoven in much of the research are analyses of effects of policy on efficiency and on forest-dependent communities.
Multispecies Stories from the Margins
Authors: Rantala Outi , Höckert Emily 
Published: November 2023

AbstractThis chapter seeks to cultivate the art of attentiveness to more-than-human ways of being and knowing that have ended up in the margins of our everyday attention. It problematises the human-centred idea of marginality by engaging in multispecies storytelling with local mosses in the Pyhä-Luosto National Park in northern Finland. The authors explore the possibilities of including non-human voices in the place-making and tourism development processes, posing questions on mobility and wellbeing and growth from mosses’ point of view. Following in the footsteps of Robin Wall Kimmerer, the chapter asks what could be learnt from mosses that have succeeded in surviving in nearly every ecosystem on earth longer than any other plant groups. The authors introduce multispecies storytelling as a genre that encourages us to slow down, attune with alternative rhythms and temporalities, listen to more-than-human concerns and further mobilise inspiration, activism and hope. While mosses are generally perceived as something insignificant, one of their many secrets seems to lie in their ability to take full advantage of being slow, small and flourishing in the shade. Hence, by attuning to mosses’ life-sustaining agencies, the authors propose smallness and slowness as key features in living well on Earth.
Einleitung
Authors: Wan Shujun 
Published: November 2023

ZusammenfassungEinen schönen Text zu schreiben ist nie eine leichte Aufgabe. Um eine sichere Schreibfähigkeit erwerben zu können, müssen selbst Muttersprachler/-innen schon von jungen Jahren an u. a. darin trainiert werden, unterschiedliche Textvarietäten zu unterscheiden und entsprechende Schreibstrategien zu entwickeln. Dementsprechend stellt dies für Nicht-Muttersprachler/-innen eine noch weitaus größere Herausforderung dar.
Entrustable Professional Activities (EPA) im Modellstudiengang Zahnmedizin „iMED DENT“ am Universitätsklinikum Hamburg-Eppendorf
Authors: Heydecke Guido , Mirzakhanian Christine 
Published: November 2023

ZusammenfassungIm Studium der Zahnmedizin nimmt die Ausbildung klinischer Tätigkeiten einen besonderen Stellenwert ein, da ab dem 7. Fachsemester Behandlungen an Patient:innen durchgeführt werden. Die Kompetenzen eines Zahnarztes müssen zum Antritt des Staatsexamens für die sich daran anschließende Berufsausübung vorliegen. Die zu erlernenden klinischen Tätigkeiten erfordern eine Vorbereitung durch präklinische Übungen und frühen Patientenkontakt schon vor dem 7. Fachsemester sowie den Ausbau der Kompetenzen in einem Schritt-für-Schritt-Vorgehen. Bei der Entwicklung des Modellstudiengangs iMED DENT am Universitätsklinikum Hamburg-Eppendorf wurde hierfür ein Katalog an „anvertraubaren professionellen Tätigkeiten“ (EPA) erstellt. Eine EPA ist definiert als eine anvertraubare klinische Tätigkeit (z. B. Herstellung einer Einzelkrone als festsitzender Zahnersatz), die zum Zeitpunkt der Durchführung ein definiertes Kompetenzniveau erreicht. Innerhalb einer EPA werden die Kompetenzen Theorie, praktisches Geschick und Umgang mit Patient:innen ausgebildet. Das verwendete Bewertungsformat muss sicherstellen, dass die darüber geleisteten Rückmeldungen zur Qualität der durchgeführten klinischen Behandlungsschritte die jeweils relevanten Kompetenzen erfassen. Die Bewertung der Kompetenzen innerhalb der EPA wird mit einem abgestuften Bewertungsschema vorgenommen (A = sehr gut, B = gut, C = schlecht, D = Leistung nicht/unvollständig erbracht). Das Bewertungsschema dient als Feedback-Werkzeug zur Verbesserung des Lernerfolgs und ist gleichzeitig Grundlage für die Bewertung der hochschulinternen Prüfungen.
A note on Bohr’s theorem for Beurling integer systems
Authors: Broucke Frederik , Kouroupis Athanasios , Perfekt Karl-Mikael 
Published: November 2023

AbstractGiven a sequence of frequencies $$\{\lambda _n\}_{n\ge 1}$$

{

λ
n

}

n
≥
1

, a corresponding generalized Dirichlet series is of the form $$f(s)=\sum _{n\ge 1}a_ne^{-\lambda _ns}$$

f

(
s
)

=

∑

n
≥
1

a
n

e

-

λ
n

s

. We are interested in multiplicatively generated systems, where each number $$e^{\lambda _n}$$

e

λ
n

arises as a finite product of some given numbers $$\{q_n\}_{n\ge 1}$$

{

q
n

}

n
≥
1

, $$1 < q_n \rightarrow \infty $$

1
<

q
n

→
∞

, referred to as Beurling primes. In the classical case, where $$\lambda _n = \log n$$

λ
n

=
log
n

, Bohr’s theorem holds: if f converges somewhere and has an analytic extension which is bounded in a half-plane $$\{\Re s> \theta \}$$

{
ℜ
s
>
θ
}

, then it actually converges uniformly in every half-plane $$\{\Re s> \theta +\varepsilon \}$$

{
ℜ
s
>
θ
+
ε
}

, $$\varepsilon >0$$

ε
>
0

. We prove, under very mild conditions, that given a sequence of Beurling primes, a small perturbation yields another sequence of primes such that the corresponding Beurling integers satisfy Bohr’s condition, and therefore the theorem. Applying our technique in conjunction with a probabilistic method, we find a system of Beurling primes for which both Bohr’s theorem and the Riemann hypothesis are valid. This provides a counterexample to a conjecture of H. Helson concerning outer functions in Hardy spaces of generalized Dirichlet series.
Breast anthropometry in Vietnamese youth: a comprehensive study of 128 women
Authors: Nguyen Dinh Minh , Tran Thiet Son , Nguyen Ngoc Tuan , Le Thi Nga , Nguyen Duc Hoang , Nguyen Tran-Thuy 
Published: November 2023

Abstract
Background
Breast anthropometry research, evaluating the correlation between various breast anthropometric values with each other, is of great importance to the field of cosmetic and reconstructive surgery. The research aims to describe the anthropometric features of the breasts of young Vietnamese women and compare them with other women’s groups worldwide.

Methods
The study was conducted on 128 nulliparous Vietnamese women, aged 18–25, with body mass index within the range of 18.5–25 kg/m2. Nineteen research indexes were divided into 3 groups: group 1 (general anthropometric indexes—3 indexes), group 2 (indexes related to the chest and breast—7 indexes), and group 3 (purely breast indexes—9 indexes). The breast volume was calculated according to the formula of author Qiao1: V = 3.14/3 * MP2 * (LR + MR + IR − MP) (ml).

Results
The mean age was 18.6 ± 6, and the mean BMI was 21 ± 1.6 kg/m2. The mean breast volumes on the right and left were 437.1 ± 266.8 ml and 457 ± 259.7 ml, respectively. The left breast volume was significantly larger than the right. The mean areola diameter was 3.4 ± 0.6 cm. There was a strong correlation (r > 0.5) between breast volume and 8 indexes: breast projection, medial mammary radius, nipple-inframammary fold length, lateral mammary radius, right suprasternal notch-to-nipple distance, chest circumference through the nipple, breast base width, and mid-clavicular point-to-nipple distance. There was no correlation between height and breast volume.

Conclusions
This study contributes valuable data to the breast anthropometry database of young, nulliparous Vietnamese women, which could be effectively applied in cosmetic and reconstructive breast surgery in addition to existing literature.
Level of Evidence: Level III, Diagnostic; Risk/Prognostic.
A single-center cross-sectional study comparison between quality of life after penile inversion and sigmoid colon vaginoplasty in Thailand: a 20-year experience
Authors: Weerapakorn Weerayut , Chintavalakorn Chuthada , Kantagowit Piyawat , Phitakwongroj Threerapat , Ratanalert Worapon , Angspatt Apichai , Phungrasmi Pornthep , Iamphongsai Seree , Promniyom Pasu , Phanuphak Nittaya , Yodkitudomying Chatnapa , Suwajo Poonpissamai 
Published: November 2023

Abstract
Background
Penile skin inversion vaginoplasty (PIV) and sigmoid colon vaginoplasty (SCV) are both regarded as surgical options for gender reassignment surgery (GRS) to improve quality of life (QoL) in male-to-female (MTF) individuals. As no studies have compared the QoL between PIV and SCV techniques, this study aimed to evaluate the differences in QoL among MTF individuals who received PIV and SCV.

Methods
A cross-sectional study was conducted on patients who underwent GRS using PIV and SCV techniques at King Chulalongkorn Memorial Hospital (KCMH) from January 2002 to December 2022. The calibrated Thai version of Short-Form 36-Question Health Survey version 2 (SF-36v2) was used to assess QoL across eight health domains and to compare QoL between two surgical techniques.

Results
Of the 278 eligible MTF patients, who received GRS from 2002 to 2022, 57 completed the questionnaires; 37 and 20 MTF patients underwent PIV and SCV, respectively. Statistically significant difference was found in the Mental Component Summary (p-value = 0.02) of postoperative QoL between the two groups. SCV statistically outperformed PIV in seven out of eight domains.

Conclusion
In terms of QoL, MTF who underwent SCV showed better achievement than those who underwent PIV in most of the domains. Due to limitations of this study, further studies on a larger scale are needed to confirm the findings and compare other aspects of the surgical techniques.
Level of Evidence: Level III, Therapeutic.
The association between embedded catheter implantation and hospitalization costs for peritoneal dialysis initiation: a retrospective cohort study
Authors: Shinzawa Maki , Matsumoto Ayumi , Kitamura Harumi , Sakaguchi Yusuke , Takahashi Atsushi , Matsui Isao , Mizui Masayuki , Yamamoto Ryohei , Isaka Yoshitaka 
Published: November 2023

Abstract
Background
Compared with the conventional peritoneal dialysis (PD) catheter insertion, embedding PD catheter implantation is one of the procedures for planned PD initiation. However, facilities where embedded PD catheter implantation is available are limited, and the impact of embedded PD catheter implantation on hospitalization cost and length of hospitalization is unknown.

Methods
This retrospective single-center cohort study included 132 patients with PD initiation between 2005 and 2020. The patients were divided into two groups: 64 patients in the embedding group and 68 patients in the conventional insertion group. We created a multivariable generalized linear model (GLM) with the gamma family and log-link function to evaluate the association among catheter embedding, the duration and medical costs of hospitalization for PD initiation. We also evaluated the effect modification between age and catheter embedding.

Results
Catheter embedding (β coefficient − 0.13 [95% confidence interval − 0.21, − 0.05]) and age (per 10 years 0.08 [0.03, 0.14]) were significantly associated with hospitalization costs. Catheter embedding (− 0.21 [− 0.32, − 0.10]) and age (0.11 [0.03, 0.19]) were also identified as factors significantly associated with length of hospitalization. The difference between the embedding group and the conventional insertion group in hospitalization costs for PD initiation (P for interaction = 0.060) and the length of hospitalization (P for interaction = 0.027) was larger in young-to-middle-aged patients than in elderly patients.

Conclusions
Catheter embedding was associated with lower hospitalization cost and shorter length of hospitalization for PD initiation than conventional PD catheter insertion, especially in young-to-middle-aged patients.
Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study
Authors: Ikejiri Kazuaki , Suzuki Takafumi , Muto Satsuki , Takama Hirotaka , Yamawaki Kengo , Miyazawa Tatsuya , Urakawa Itaru , Aoki Yuichi , Otsuki Akihito , Katsuoka Fumiki , Kinoshita Kengo , Nangaku Masaomi , Akizawa Tadao , Yamamoto Masayuki 
Published: November 2023

Abstract
Background
In the TSUBAKI study, bardoxolone methyl significantly increased measured and estimated glomerular filtration rates (GFR) in patients with multiple forms of chronic kidney disease (CKD), including Japanese patients with type 2 diabetes and stage 3–4 CKD. Since bardoxolone methyl targets the nuclear factor erythroid 2–related factor 2 pathway, this exploratory analysis of the TSUBAKI study investigated the impact of the regulatory single nucleotide polymorphism, rs6721961, on the effects of bardoxolone methyl.

Methods
Japanese patients aged 20–79 years with type 2 diabetes and stage 3–4 CKD were randomized to bardoxolone methyl 5–15 mg/day (titrated as tolerated) or placebo for 16 weeks. Genotype frequency, clinical characteristics, renal function, and adverse events were primarily assessed.

Results
Of 104 patients (bardoxolone methyl n = 55, placebo n = 49); 57% were genotype C/C, 32% C/A and 12% A/A. The frequency of the A/A genotype was higher among patients with diabetic kidney disease than in the general Japanese population (~ 5%). Measured and estimated GFRs increased from baseline in all genotypes receiving bardoxolone methyl. There were no significant differences between genotypes for safety parameters, including blood pressure, bodyweight, and levels of B-type natriuretic peptide, or in the type and frequency of adverse events, suggesting that the efficacy and safety of bardoxolone methyl are unaffected by the rs6721961 polymorphism-617 (C﻿→A) genotype.

Conclusions
Our approach of combining genome analysis with clinical trials for an investigational drug provides important and useful clues for exploring the efficacy and safety of the drug.

Trial registration
ClinicalTrials.gov; NCT02316821.