bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing online social support for alcohol use disorder: A mixed‐methods approach
Authors: Colditz Jason B. , Chu Kar‐Hai , Hsiao Lily , Barrett Erica , Kraemer Kevin L. , Pedersen Sarah L. 
Published: November 2023

AbstractBackgroundOnline social media communities are increasingly popular venues for discussing alcohol use disorder (AUD) and recovery. Little is known about distinct contexts of social support that are exchanged in this milieu, which are critical to understanding the social dynamics of online recovery support.MethodsWe randomly selected one post per day over the span of a year from the StopDrinking recovery forum. Direct responses to posts were double coded within an established theoretical framework of social support. Within a mixed‐methods research framework, we quantified the linguistic characteristics of 1386 responses (i.e., text length, complexity, and sentiment) and qualitatively explored themes within and among different types of social support.ResultsEmotional support was most prevalent (74% of responses) and appeared as the sole form of support in 38% of responses. Emotionally supportive responses were significantly shorter, less complex, and more positively valenced than other support types. Appraisal support was also common in 55% of responses, while informational support was identified in only 17%. There was substantial overlap among support types, with 40% of responses including two or more types. Salient themes included the common use of community‐specific acronyms in emotional support. Appraisal support conveyed feedback about attitudes and behaviors that are perceived as (un‐) favorable for AUD recovery. Informational support responses were composed primarily of recommendations for self‐help literature, clinical treatment approaches, and peer recovery programs.ConclusionsSocial support in this sample was primarily emotional in nature, with other types of support included to provide feedback and guidance (i.e., appraisal support) and supplemental recovery resources (i.e., informational support). The provided social support framework can be helpful in characterizing community dynamics among heterogeneous online AUD recovery support forums. This framework could also be helpful in considering changes in support approaches that correspond to progress in recovery.
Multi‐omics analysis of alcohol effects on the liver in young and aged mice
Authors: Zillich Lea , Wagner Josephin , McMahan Rachel H. , Park Lauren M. , Hodgkinson Colin , Kovacs Elizabeth J. , Lohoff Falk W. 
Published: November 2023

AbstractExcessive alcohol consumption has detrimental effects on the entire organism, especially on the liver. The toxicity is partly dependent on age, as older individuals metabolize alcohol more slowly leading to increased cellular injury. This study aimed to investigate the effects of moderate binge drinking on the liver of young and aged mice in a genome‐wide multi‐omics approach. We determined DNA methylation (DNAm) using the Illumina MouseMethylation array and gene expression by RNA sequencing in 18 female Balb/c mice in a 2 × 2 design. The animals underwent three moderate binge drinking cycles (ethanol vs. vehicle) and liver tissue was harvested at 4 or 19 months of age. We tested differential gene expression (DE) and DNAm associated with ethanol intake in linear models separately in young and aged mice, performed enrichment analyses for pathways and GWAS signatures of problematic alcohol use, and analysed the overlap of DNAm and gene expression. We observed DE in young and aged animals and substantial overlap in genes such as Bhlhe40, Klf10, and Frmd8. DE genes in aged animals were enriched for biological processes related to alcohol metabolism, inflammation, liver fibrosis, and GWAS signatures of problematic alcohol use. We identified overlapping signatures from DNAm and gene expression, for example, Frmd8 in aged and St6galnac4 in young mice. This study offers converging evidence of novel age‐related targets in a moderate alcohol consumption model highlighting dysregulations in genes related to alcohol metabolism, inflammation, and liver fibrosis. Future studies are needed to confirm these results and elucidate the underlying mechanisms.
The role of psychosocial factors in the interprofessional management of women with chronic pelvic pain: A systematic review
Authors: Klotz Susanne G. R. , Kolbe Clarissa , Rueß Miriam , Brünahl Christian A. 
Published: November 2023

AbstractIntroductionChronic pelvic pain (CPP) is a common pain disorder in women associated with negative biopsychosocial consequences. The multifactorial etiology and maintaining aspects of CPP logically require an interprofessional treatment approach. However, the effects of interprofessional treatment strategies on psychosocial factors remain unclear. The study aims to investigate how interprofessional therapy helps to treat psychosocial factors in women with CPP. The systematic review summarizes the current evidence of interprofessional treatment in women with CPP.Material and methodsA systematic literature review was performed in six databases (Medline, Web of Science, Cochrane Library, PEDro, CINAHL, and PsycINFO) until February 2023. Studies were selected in a two‐step approach applying as inclusion criteria the search combinations of Chronic Pelvic Pain and CPP, synonyms for interprofessional therapies, and for female patients. Studies were excluded if they were not quantitative primary research published in English, if CPP was not defined appropriately, if the study population was not female adult patients, if the interprofessional intervention was not operationalized appropriately, if they were single case studies, and if outcomes did not include at least one of the psychosocial factors pain, depressive symptoms, pain catastrophizing, fear, or anxiety. Risk of bias of the included studies was rated with the McMaster Critical Review Form. Studies were summarized narratively. The review is registered in PROSPERO (CRD42023391008).ResultsFive studies with a total sample size of n = 186 women were included, three of them were uncontrolled retrospective before‐after chart review. Only one study used a randomized controlled design, the other study used a non‐randomized controlled group. The studies' methodological quality is adequate with perspective of study design. The multiprofessional treatment approaches used in the studies differed with regard to professions involved, therapy methods, and modalities. Psychosocial outcome measures were pain (five studies), depressive symptoms (three studies), and anxiety symptoms (four studies).ConclusionsAlthough interprofessional treatment strategies for women with CPP are recommended in existing guidelines, available evidence is scarce and does not allow for identification of the best interprofessional treatment approach. The effect on psychosocial factors remains unclear. More research is needed determining the best practice interprofessional treatment option for women with CPP.
Computational investigation of outflow graft variation impact on hemocompatibility profile in LVADs
Authors: Zambrano Byron A. , Wilson Shannon I. , Zook Salma , Vekaria Bansi , Moreno Michael R. , Kassi Mahwash 
Published: November 2023

AbstractBackgroundHemocompatibility‐related adverse events (HRAE) occur commonly in patients with left ventricular assist devices (LVADs) and add to morbidity and mortality. It is unclear whether the outflow graft orientation can impact flow conditions leading to HRAE. This study presents a simulation‐based approach using exact patient anatomy from medical images to investigate the influence of outflow cannula orientation in modulating flow conditions leading to HRAEs.MethodsA 3D model of a proximal aorta and outflow graft was reconstructed from a computed tomography (CT) scan of an LVAD patient and virtually modified to model multiple cannula orientations (n = 10) by varying polar (cranio‐caudal) (n = 5) and off‐set (anterior–posterior) (n = 2) angles. Time‐dependent computational flow simulations were then performed for each anatomical orientation. Qualitative and quantitative hemodynamics metrics of thrombogenicity including time‐averaged wall shear stress (TAWSS), oscillatory shear index (OSI), endothelial cell platelet activation potential (ECAP), particle residence time (PRT), and platelet activation potential (PLAP) were analyzed.ResultsWithin the simulations performed, endothelial cell activation potential (ECAP) and particle residence time (PRT) were found to be lowest with a polar angle of 85°, regardless of offset angle. However, polar angles that produced parameters at levels least associated with thrombosis varied when the offset angle was changed from 0° to 12°. For offset angles of 0° and 12° respectively, flow shear was lowest at 65° and 75°, time averaged wall shear stress (TAWSS) was highest at 85° and 35°, and platelet activation potential (PLAP) was lowest at 65° and 45°.ConclusionThis study suggests that computational fluid dynamic modeling based on patient‐specific anatomy can be a powerful analytical tool when identifying optimal positioning of an LVAD. Contrary to previous work, our findings suggest that there may be an “ideal” outflow cannula for each individual patient based on a CFD‐based hemocompatibility profile.
Probiotics for infantile colic: Is there evidence beyond doubt? A meta‐analysis and systematic review
Authors: Vaz Sáskia Ribeiro , Tofoli Marise Helena , Avelino Melissa Ameloti Gomes , da Costa Paulo Sérgio Sucasas 
Published: November 2023

AbstractAimThis study is a systematic review and meta‐analysis of randomised controlled trials that employed probiotics and symbiotics for treating infantile colic.MethodsWe performed electronic systematic literature searches in Embase, PubMed and Web of Science, to identify articles published between 1950 and April 2023. Only RCT involving infants with infantile colic under 3 months were included. The treatment plan comprised 15 probiotics, which included Lactobacillus reuteri DSM 17938 and Bifidobacterium animalis lactis BB‐12. The probiotics were administered alone or in combination with a prebiotic, vs. no intervention or a placebo.ResultsProbiotics resulted in an average reduction of 51 min of crying per day (p = 0.001). Further analysis of subgroups showed that the reduction was −39.30 min for vaginal delivery (p = 0.003), −64.66 min for Lactobacillus reuteri DSM 17938 (p = 0.03), −40.45 min for other strains (p < 0.00001), −74.28 min for exclusively breastfed infants (p = 0.0003) and −48.04 min for mixed feeding (p < 0.00001).ConclusionAll probiotic strains seem effective in treating infantile colic. Exclusively breastfed infants have demonstrated more significant reduction in crying time. However, the available evidence on the effectiveness of probiotics in formula‐fed and caesarean‐born infants is limited.
Challenges in defining treatment‐resistant mania in adults: A systematic review
Authors: Gonzalez‐Torres Christina , Mulsant Benoit H. , Husain M. Ishrat , Alda Martin , Young Robert C. , Ortiz Abigail 
Published: November 2023

AbstractObjectivesTo review the definitions of treatment‐resistant mania (TRM) in the literature and propose criteria for an operationalized definition.MethodsA systematic search of five databases (MEDLINE, EMBASE, PsychInfo, Cochrane Central, and CINAHL) and data extraction of eligible articles.ResultsIn total, 47 articles addressing the concept of TRM were included, comprising 16 case reports, 11 case series, 3 randomized clinical trials, 8 open‐label clinical trials, 1 experimental study, 7 narrative reviews, and 1 systematic review. While reviews discussed several challenges in defining TRM, definitions varied substantially based on different criteria for severity of mania, duration of mania, and use of specific therapeutic agents with minimal dosages and duration of treatment. Only a handful of the reviewed articles operationalized these criteria.ConclusionWhile the concept of TRM has been discussed in the literature for over three decades, we could not find an agreed‐upon operationalized definition based on specific criteria. We propose and discuss a possible definition that could be used by clinicians to guide their practice and by researchers to assess the prevalence of TRM and develop and test interventions targeting TRM.
Association between genetic variants of transmembrane transporters and susceptibility to anthracycline‐induced cardiotoxicity: Current understanding and existing evidence
Authors: Ni Ming‐Ming , Yang Ju‐Fei , Miao Jing , Xu Jin 
Published: November 2023

AbstractAnthracyclines remain the cornerstone of numerous chemotherapeutic protocols, with beneficial effects against haematological malignancies and solid tumours. Unfortunately, the clinical usefulness of anthracyclines is compromised by the development of cardiotoxic side effects, leading to dose limitations or treatment discontinuation. There is no absolute linear correlation between the incidence of cardiotoxicity and the threshold dose, suggesting that genetic factors may modify the association between anthracyclines and cardiotoxicity risk. And the majority of single nucleotide polymorphisms (SNPs) associated with anthracycline pharmacogenomics were identified in the ATP‐binding cassette (ABC) and solute carrier (SLC) transporters, generating increasing interest in the pharmacogenetic implications of their genetic variations for anthracycline‐induced cardiotoxicity (AIC). This review focuses on the influence of SLC and ABC polymorphisms on AIC and highlights the prospects and clinical significance of pharmacogenetics for individualised preventive approaches.
Pollen associated with a Texas population of blow flies‐(Diptera: Calliphoridae) highlights underappreciated aspects of their biology
Authors: Rangel Juliana , Lau Pierre , Strauss Brandon , Hildinger Emily , Hernandez Betty , Rodriguez Stephanie , Bryant Vaughn , Tarone Aaron M. 
Published: November 2023

Abstract
Over 80% of agricultural crops rely on insect pollination. Thus, pollinator biodiversity is critical for augmented plant yield and quality.
Blow flies (Diptera: Calliphoridae) are acknowledged pollinators of several crops. However, there are many open questions regarding their importance in pollination ecology. For instance, there has not been a comprehensive assessment of pollen use by blow flies, and thus, it is unknown whether individuals visit few or many plant types per trip.
At least one blow fly species (Lucilia sericata) can digest pollen and use the protein therein as an oogenic resource. However, it is unknown whether this is a commonly used strategy for protein acquisition, given that they are more commonly associated with faeces, carrion and myiasis.
We surveyed the pollen found in blow fly guts to determine whether blow flies (a) consume pollen, and if so, which types of pollen; (b) exhibit species‐specific pollen use and (c) demonstrate sex‐specific pollen use.
We collected blow flies from natural habitats around Central Texas from 2016 to 2019 and dissected their guts to look for the presence of pollen. We found widespread use of pollen from a variety of plants by six blow fly species and discovered a bias in the amount of pollen collected by female blow flies compared with males in some, but not all fly species.
Pollen represents a relatively underappreciated aspect of blow fly biology, with the potential for several underappreciated ecological impacts ranging from disease ecology to plant diversity.
A novel, post‐Soviet fire disturbance regime drives bird diversity and abundance on the Eurasian steppe
Authors: Bhagwat Tejas , Kuemmerle Tobias , Soofi Mahmood , Donald Paul F. , Hölzel Norbert , Salemgareev Albert , Stirnemann Ingrid , Urazaliyev Ruslan , Baumann Matthias , Kamp Johannes 
Published: November 2023

AbstractMany grassland ecosystems and their associated biodiversity depend on the interactions between fire and land‐use, both of which are shaped by socioeconomic conditions. The Eurasian steppe biome, much of it situated in Kazakhstan, contains 10% of the world's remaining grasslands. The break‐up of the Soviet Union in 1991, widespread land abandonment and massive declines in wild and domestic ungulates led to biomass accumulation over millions of hectares. This rapid fuel increase made the steppes a global fire hotspot, with major changes in vegetation structure. Yet, the response of steppe biodiversity to these changes remains unexplored. We utilized a unique bird abundance dataset covering the entire Kazakh steppe and semi‐desert regions together with the MODIS burned area product. We modeled the response of bird species richness and abundance as a function of fire disturbance variables—fire extent, cumulative burned area, fire frequency—at varying grazing intensity. Bird species richness was impacted negatively by large fire extent, cumulative burned area, and high fire frequency in moderately grazed and ungrazed steppe. Similarly, overall bird abundance was impacted negatively by large fire extent, cumulative burned area and higher fire frequency in the moderately grazed steppe, ungrazed steppe, and ungrazed semi‐deserts. At the species level, the effect of high fire disturbance was negative for more species than positive. There were considerable fire legacy effects, detectable for at least 8 years. We conclude that the increase in fire disturbance across the post‐Soviet Eurasian steppe has led to strong declines in bird abundance and pronounced changes in community assembly. To gain back control over wildfires and prevent further biodiversity loss, restoration of wild herbivore populations and traditional domestic ungulate grazing systems seems much needed.
Biochar and manure additions increased above‐ and belowground wood decomposition, and soil enzyme activities in a sandy loam soil
Authors: Zhao Ruirui , Page‐Dumroese Deborah S. , Liu Yong , Wang Kai , Dumroese R. Kasten 
Published: November 2023

AbstractWhile biochar and manure can provide considerable benefits to soil properties, how these amendments may alter soil microbial activity and decomposition processes remains unknown. In a split‐split‐split‐plot experiment, we amended a sandy loam soil with three rates of manure (whole plot; 0, 3, 9 Mg ha−1) and biochar (split‐plot; 0, 2.5, 10 Mg ha−1), and installed three species of wood stakes (split‐split‐split plot; triploid poplar, Populus tomentosa Carr.; trembling aspen, Populus tremuloides Michx.; and loblolly pine, Pinus taeda L.) on the soil surface and in the mineral soil (split‐split plot) to serve as a substrate for microbial degradation. Wood stakes were sampled 3 years after installation to assess decomposition rates (mass loss), and changes in wood carbon (C) and nitrogen (N). In addition, soil extracellular enzyme activities at the 0–20 cm depth were examined. Biochar alone, especially 10 Mg ha−1, increased wood stake decomposition and moisture content on the soil surface and in the mineral soil. Manure at the rate of 9 Mg ha−1 increased soil N‐acetyl‐β‐D‐glucosaminidase, α‐glucosidase, and aryl sulfatase activities by 91%, 17%, and 48% respectively. Because of the synergistic benefits of biochar and manure, we suggest that, in this climatic regime and soil texture, 10 Mg ha−1 biochar can be used for soil C sequestration and soil quality improvement, and 9 Mg ha−1 manure can be used in combination with biochar to build soil organic matter in plantations.
Criticising as a disciplinary action: A problem for learners of Chinese as a foreign language?
Authors: Liu Fengguang , Shi Wenrui , Kádár Dániel Z. , House Juliane 
Published: November 2023

AbstractIn this study, we examine how criticising as a disciplinary action is conventionally realised in Chinese classroom contexts. By so doing, we provide a two‐fold contribution to the current special issue dedicated to Willis Edmondson. First, we examine criticising in an innovative way, by going beyond its traditional interpretation as a speech act, that is, we approach it as an interactional phenomenon which is conventionally realised by a cluster of expressions and speech acts. Second, we propose a bipartite approach to examine why and how instances of criticism as a disciplinary action in Chinese may puzzle foreign learners of Chinese.
CCR5 promoter polymorphisms associated with nonsmall cell lung cancer
Authors: Lu Tianchang , Shi Yuhan , Wang Minyi , Liu Weipeng , Cao Yang , Shi Li , Ma Qianli , Liu Shuyuan 
Published: November 2023

AbstractC–C chemokine receptor 5 (CCR5) plays a crucial role in the regulation of immune cell activation and migration as well as the progression of many cancers. We performed an in silico analysis using public data resources and found that the lung cancer patients with higher CCR5 expression had a notably better overall survival than those with lower CCR5 expression patients and CCR5 expression level is positive correlated with the infiltration of immune cells, such as B, CD8+ T and CD4+ T cells, in both lung adenocarcinoma and lung squamous cell cancer. In the present study, we investigated the association between the promoter polymorphism of CCR5 and nonsmall cell lung cancer (NSCLC). A case‒control study of 449 NSCLC patients and 516 controls of Chinese Han population was conducted, along with polymorphism detection using a sequencing method. A dual‐luciferase reporter assay system was used to analyse the transcriptional activity of CCR5 promoter variations. Our results showed that the frequency of rs1799987‐AA was significantly higher in the NSCLC group than in the controls in recessive model (p = .007, OR = 1.66 95% confidence interval [CI]: 1.14–2.40, adjusted by sex and age); the G allele showed a significant associated with NSCLC in dominant model (p = .003, OR = 1.64, 95%CI: 1.18–2.28, adjusted by sex and age). Compared with haplotype H1 rs2227010–rs2734648–rs1799987–rs1799988–rs1800023–rs1800024: A‐T‐G‐T‐G‐C, haplotype H5: A‐G‐G‐T‐G‐C increased the risk of NSCLC by over 10‐fold (p < .0001, OR = 16.09, 95%CI: 5.37–48.20, adjusted by sex and age) and notably depressed the transcriptional activity of the CCR5 promoter in 293T, A549, H1299 and HeLa cells. In conclusion, CCR5 promoter polymorphisms are significantly associated with NSCLC by affecting the transcriptional activity of the CCR5 promoter.
Characterisation of lepidopteran geranylgeranyl diphosphate synthase as a putative pesticide target
Authors: Katsavou Evangelia , Sarafoglou Chara , Balabanidou Vasileia , Skoufa Evangelia , Nauen Ralf , Linka Marc , Geibel Sven , Denecke Shane , Vontas John 
Published: November 2023

AbstractGeranylgeranyl pyrophosphate (diphosphate) synthase (GGPPS) plays an important role in various physiological processes in insects, such as isoprenoid biosynthesis and protein prenylation. Here, we functionally characterised the GGPPS from the major agricultural lepidopteran pests Spodoptera frugiperda and Helicoverpa armigera. Partial disruption of GGPPS by CRISPR in S. frugiperda decreased embryo hatching rate and larval survival, suggesting that this gene is essential. Functional expression in vitro of Helicoverpa armigera GGPPS in Escherichia coli revealed a catalytically active enzyme. Next, we developed and optimised an enzyme assay to screen for potential inhibitors, such as the zoledronate and the minodronate, which showed a dose‐dependent inhibition. Phylogenetic analysis of GGPPS across insects showed that GGPPS is highly conserved but also revealed several residues likely to be involved in substrate binding, which were substantially different in bee pollinator and human GGPPS. Considering the essentiality of GGPPS and its putative binding residue variability qualifies a GGPPS as a novel pesticide target. The developed assay may contribute to the identification of novel insecticide leads.