bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of PCV-2 viremia in nursery piglets from a Spanish swine integration system in 2020 and 2022 considering PRRSV infection status
Authors: Sagrera Mònica , Garza-Moreno Laura , Sibila Marina , Oliver-Ferrando Salvador , Cárceles Sonia , Casanovas Carlos , Prieto Patricia , García-Flores Alberto , Espigares David , Segalés Joaquim 
Published: January 2024

AbstractBackgroundPorcine circovirus 2 (PCV-2) poses a significant economic threat for the swine industry, causing a range of diseases collectively referred to as porcine circovirus diseases (PCVDs). Despite PCV-2 vaccine effectiveness, the need for monitoring infectious pressure remains. PCV-2 coinfection with other pathogens like porcine reproductive and respiratory syndrome virus (PRRSV) can exacerbate disease severity and lead to PCV-2-systemic disease cases. Monitoring both PRRSV and PCV-2 in co-infected farms is crucial for an effective management and vaccination programs. The present cross-sectional study aimed to determine PCV-2 antibody levels in piglets at weaning and PCV-2 and PRRSV viremia in pooled serum samples at weaning (vaccination age) and at 6 and 9 weeks of age from a Spanish swine integration system in 2020 (48 farms) and in 2022 (28 out of the 48 analysed previously).ResultsThe frequency of PCV-2 detection in pools of piglet sera was 2.1% (2020) and 7.1% (2022) at vaccination age but increased at the end of the nursery period (10.4% in 2020 and 39.3% in 2022) in both years. Co-infections between PCV-2 and PRRSV were detected in a significant proportion of PRRSV positive farms (15% in 2020, and 60% in 2022). PCV-2 antibody levels (ELISA S/P ratios) at weaning were lower in PCV-2 qPCR positive farms at different sampling time-points (0.361 in 2020 and 0.378 in 2022) compared to PCV-2 qPCR negative ones (0.587 in 2020 and 0.541 in 2022). The 28 farms tested both years were classified in four different epidemiological scenarios depending on their PCV-2 virological status. Those PCV-2 qPCR negative farms in 2020 that turned to be positive in 2022 had a statistically significant increase of PRRSV RT-qPCR detection and a PCV-2 antibody levels reduction, facts that were not observed in the rest of the scenarios.ConclusionThis epidemiological study in farms from the same integration system determined the occurrence, in 2020 and in 2022, of PCV-2 and PRRSV infections in piglets during the nursery period by using pooled serum samples.
Exploring the critical factors affecting the adoption of blockchain: Taiwan’s banking industry
Authors: Lu Yi-Hsiang , Yeh Ching-Chiang , Kuo Yu-Mei 
Published: January 2024

AbstractAs an emerging technology, blockchain has recently gained attention in both academic and economic fields, but its adoption is not yet widespread in the banking sector in Taiwan. As academics have paid scant attention to this topic, this study determines the critical factors affecting blockchain adoption from the organizational perspective in the banking industry. We propose hybrid methods to fill the gap in the literature. First, we apply the technology-organization-environment framework as the basis and combine relevant factors as a framework to identify the relevant evaluation factors. Second, we propose a hybrid method that integrates the decision-making trial and evaluation laboratory (DEMATEL) with the evaluation based on distance from average solution (EDAS) approach and employs DEMATEL to measure the importance of the factors and alternatives to blockchain as ranked by the EDAS method. According to the ranking results, we identify the best preference among alternatives to blockchain. The results suggest that organizational and technological aspects are the main considerations to enhance and promote the effectiveness of blockchain adoption. This study suggests valuable strategies for stimulating blockchain adoption in the banking sector in Taiwan.
Leg length discrepancy before total knee arthroplasty is associated with increased complications and earlier time to revision
Authors: Mekkawy Kevin L. , Davis Ty , Sakalian Philip A. , Pino Alejandro E. , Corces Arturo , Roche Martin W. 
Published: January 2024

Abstract
Introduction
Leg length discrepancy (LLD) following total knee arthroplasty (TKA) is a common complaint, leading to decreased patient satisfaction. However, the effect of LLD diagnosis prior to TKA on outcomes and complications is not well defined. Thus, this study aimed to assess the effects that LLD has on rates of falls and implant complications, length of stay and readmissions, and implant survivorship following TKA.

Methods
A retrospective review of a private insurance claims database was conducted from 2010 to 2021. All cases of TKA and those with a diagnosis of leg length discrepancy were identified. Patients undergoing TKA with a diagnosis of LLD were matched to control patients 1:5 based on demographic and comorbidity profiles. Two-year fall rates and implant complications, lengths of stay, 90-day readmissions, and time to revision were compared between cohorts.

Results
A total of 1,378 LLD patients were matched to 6,889 control patients. The LLD group had significantly higher rates of falls, dislocation, mechanical loosening, periprosthetic fracture, and fibrosis when compared to the control group (all P < 0.01). Additionally, mean length of stay was significantly greater in the LLD group (4.9 days vs. 3.0 days, P < 0.001). There was no significant difference in 90-day readmission rates between groups (P = 0.178). Time to revision was significantly shorter in the LLD group (392 days vs. 928 days, P < 0.001).

Conclusions
Leg length discrepancy in patients undergoing TKA was associated with significantly increased fall risk, rates of implant complications, length of stay, and faster time to revision. The findings of this study may allow orthopedic surgeons to identify those patients at risk and allow for more educated patient counseling and operative planning.

Level of evidence
III, retrospective case–control study.

Graphical Abstract
Another formulation of the fractional nonlinear Schrödinger equation
Authors: Paglan Paul André , Nguenang Jean Pierre 
Published: January 2024

Abstract
In this letter, we pave the way to establish the formulation of a non-trivial fractional Nonlinear Schrödinger (NLS) equation, which is different from the formulations known so far that consist in directly replacing the integer orders of the derivatives by non-integer ones. Thereafter, we set up some formulations, adapted to some particular physical cases, namely, the cases where the nonlinearity is stronger than the dispersion, in addition to one for which the dispersion strongly dominates the nonlinearity and also the case where the system displays a nonlinearity which is compensated with the dispersion. These formulations highlight the fact that the transition from a formal classical analysis to a fractional one could lead changes in the initial model of a given system. The research for solutions of the equations resulting from this study will undoubtedly reveal new phenomena in the different physical, biological and other systems described by the NLS equation.
Midwives as Adult Educators: An investigation of midwives’ perceptions about the educational dimension of their profession
Authors: Papageorgiou Ira , Kostourou Eleni 
Published: January 2024

This article deals with the educational dimension of Midwifery, as manifested in the context of perinatal education programmes in Greece. Despite the internationally recognized value of childbirth education in reducing perinatal mortality and morbidity, and despite the rich activity of midwives in terms of perinatal education, their role as adult educators has received limited scientific attention and support. The purpose of this study is to investigate whether and to what extent midwives teaching in perinatal programmes perceive their role as educators, as well as whether and in what way they are prepared for this role. It also investigates whether and what form of training midwives receive to their role in perinatal education. The study followed the specifications of qualitative design and data was collected through in-depth semi-structured interviews with twelve (12) midwives - trainers in perinatal education, as well as with eight (8) women and men who have participated in childbirth classes in Greece. The findings highlight the need to further support midwives in their educational role and to enhance their educational practice by integrating the principles of Adult Education.
Executive functions, listening comprehension, and metacognitive processes in childhood: Developmental profiles
Authors: Bablekou Zoe , Chrysochoou Elisavet , Kazi Smaragda 
Published: January 2024

Despite the established interplay between executive functioning and metacognition, evidence remains limited regarding children’s metacognitive monitoring in the form of offline performance estimates of their executive efficiency. Moreover, we know little about the relations among listening comprehension, executive functions, and metalinguistic awareness in childhood. The present study constitutes a first exploration of developmental profiles related to executive functioning, listening comprehension, and corresponding metacognitive-metacomprehension monitoring in periods marking their emergence and interplay. Participants were 95 preschoolers (Mage 5.5), and 109 second graders (Mage = 7.5). Executive function (i.e., working memory, inhibition, and cognitive flexibility) and a listening comprehension task were administered, along with offline performance estimates following completion of each task. Fluid and crystalized intelligence tests were also administered. Cluster analyses were applied. Across ages, one cluster was characterized by lower cognitive performance, but overestimated metacognitive judgements, while a second cluster demonstrated the exact opposite pattern. Older children performed at a higher cognitive level. Yet, metacognitive monitoring did not improve as a function of age, in the sense that a third, metacognitively accurate cluster did not emerge among second graders. Working memory and listening comprehension, along with their metacognitive-metacomprehension estimates, demonstrated the greatest contribution to the cluster solution in both age groups. The inhibition-metainhibition measures proved stronger profile determinants in the older group. The fluid intelligence measure showed a reduced contribution with age and vocabulary proved to be a weak and insignificant distinctive characteristic of the profiles emerging among preschoolers and second graders, respectively. Findings are discussed in relation to relevant research data and theoretical suggestions regarding cognitive and metacognitive development.
Behaviorism in Modern Accounting System
Authors: Mislavskaya N. 
Published: January 2024

Th e article raises the question of the infl uence of the psychological characteristics of individuals on their
professional activities, in particular on the preparation of accounting (fi nancial) statements. Based on the analysis of
Western European scientific literature, a conclusion is made about the permanent presence of an irrational component in the process of making management decisions, not only among management representatives and investors, but also among accounting employees. As a measure to reduce the impact of cognitive errors, the unification of methodological accounting procedures is proposed
Morphological and ultrastructural investigation of the posterior atlanto-occipital membrane: Comparing children with Chiari malformation type I and controls
Authors: Ravindra Vijay M. , Robinson Lorraina , Jensen Hailey , Kurudza Elena , Joyce Evan , Ludwick Allison , Telford Russell , Youssef Osama , Ryan Justin , Bollo Robert J. , Iyer Rajiv R. , Kestle John R. W. , Cheshier Samuel H. , Ikeda Daniel S. , Mao Qinwen , Brockmeyer Douglas L. 
Published: January 2024

Introduction
The fibrous posterior atlanto-occipital membrane (PAOM) at the craniocervical junction is typically removed during decompression surgery for Chiari malformation type I (CM-I); however, its importance and ultrastructural architecture have not been investigated in children. We hypothesized that there are structural differences in the PAOM of patients with CM-I and those without.

Methods
In this prospective study, blinded pathological analysis was performed on PAOM specimens from children who had surgery for CM-I and children who had surgery for posterior fossa tumors (controls). Clinical and radiographic data were collected. Statistical analysis included comparisons between the CM-I and control cohorts and correlations with imaging measures.

Results
A total of 35 children (mean age at surgery 10.7 years; 94.3% white) with viable specimens for evaluation were enrolled: 24 with CM-I and 11 controls. There were no statistical demographic differences between the two cohorts. Four children had a family history of CM-I and five had a syndromic condition. The cohorts had similar measurements of tonsillar descent, syringomyelia, basion to C2, and condylar-to-C2 vertical axis (all p>0.05). The clival-axial angle was lower in patients with CM-I (138.1 vs. 149.3 degrees, p = 0.016). Morphologically, the PAOM demonstrated statistically higher proportions of disorganized architecture in patients with CM-I (75.0% vs. 36.4%, p = 0.012). There were no differences in PAOM fat, elastin, or collagen percentages overall and no differences in imaging or ultrastructural findings between male and female patients. Posterior fossa volume was lower in children with CM-I (163,234 mm3 vs. 218,305 mm3, p<0.001), a difference that persisted after normalizing for patient height (129.9 vs. 160.9, p = 0.028).

Conclusions
In patients with CM-I, the PAOM demonstrates disorganized architecture compared with that of control patients. This likely represents an anatomic adaptation in the presence of CM-I rather than a pathologic contribution.
HP promotes neutrophil inflammatory activation by regulating PFKFB2 in the glycolytic metabolism of sepsis
Authors: Chen Song , Zhang Qian , Sun Liyan , Song Wei , Zhang Tao , Song Weidong , Wan Jian 
Published: January 2024

Background
Sepsis, described as an inflammatory reaction to an infection, is a very social health problem with high mortality. This study aims to explore the new mechanism in the progression of sepsis.

Methods
We downloaded the GSE69528 dataset to screen differentially expressed genes (DEGs) for WGCNA, in which the key module was identified and analyzed by DMNC algorithm, expression verification and ROC curve analysis to identify the hub gene. Furthermore, the hub gene was analyzed by immunoassay, and the potential mechanism of hub gene in neutrophils was investigated by in vitro experiments.

Results
The turquoise module was the key module for sepsis in WGCNA on 94 DEGs. The top 20 genes of DMNC network were verified in GSE69528 and GSE9960, and 10 significant genes were obtained for ROC analysis. Based on the ROC curves, HP was considered the hub gene in sepsis, and its expression difference in sepsis and control groups was substantially significant. Further, it was demonstrated the knockdown of HP and PFKFB3 could suppress glycolysis and inflammatory cytokine levels in dHL-60 cell treated with LPS.

Conclusion
In conclusion, HP is identified as a potential diagnostic indicator for sepsis patients, and HP promotes neutrophil inflammatory activation by regulating PFKFB2 in the glycolytic metabolism of sepsis confirmed by in vitro experiments. These will help us deepen the molecular mechanism of sepsis.
A randomised crossover trial of five cryocompression devices’ ability to reduce skin temperature of the knee
Authors: Belsey James , Reid Andrew , Paine Eloise , Faulkner James 
Published: January 2024

Background
The application of cold and pressure to the knee is a common part of post-operative rehabilitation. Skin temperature should be reduced to within 10–15 °C to optimise the therapeutic benefits of cryocompression. The purpose of this study was to investigate the ability of five different cryocompression devices to reduce skin temperature to within this therapeutic range.

Materials and methods
32 healthy adult participants (mean (SD): age 26.3 (7.9) years; BMI 24.8 (2.7) kg/m2; 20 males) were recruited for this randomised crossover study. Skin temperature was measured 20 mm distal to the patella using a k-type thermocouple every five minutes during a 30-minute treatment with one of five different cryocompression devices (Physiolab S1, GameReady, Cryo/Cuff, VPulse, and a Gel Wrap). Changes in skin temperature over time were compared to baseline within and between conditions. A subjective rating of comfort was also recorded for each device.

Results
The Physiolab S1 and GameReady devices caused significantly lower skin temperatures compared to the VPulse, Gel Wrap, and Cryo/Cuff after 30 minutes (p<0.05). 87–96% reported a positive comfort rating for the Physiolab S1, VPulse, Cryo/Cuff and Gel Wrap, whereas 53% of participants reported a positive comfort rating for the GameReady.

Conclusions
Only the Physiolab S1 and GameReady devices reduced skin temperature of the knee to within the target range of 10–15 °C. The Physiolab S1 was reportedly more comfortable than the GameReady. Clinicians should be aware of the performance differences of different cryocompression devices to understand which is most likely to provide an effective dose of cold therapy to a joint.
Asociación entre las características socio demográficasy clínicas de madres con sífilis gestacional y los recién nacidos con sífilis congénita, un estudio transversal analítico.
Authors: Ossa García Maria Isabel , Navarro Salgado Sara Carolina 
Published: January 2024

Antecedentes: La sífilis congénita se considera un problema de salud pública debido a su impacto directo en la población. De no ser detectada, podría conllevar múltiples complicaciones.
Objetivo: Establecer la relación entre las características clínicas y sociodemográficas de las madres con sífilis gestacional y el diagnóstico de sífilis congénita a partir de la descripción de registros del Municipio de Armenia, Quindío, en el periodo de 2016-2021.
Metodología: Se realizó un estudio transversal analítico que incluyó todos los registros de la base de datos de vigilancia epidemiológica en salud pública del municipio de Armenia. Se descartaron los registros que superaban el 10 % de datos faltantes. Se estableció como variable dependiente la presencia o ausencia de sífilis congénita en recién nacidos. Se realizó un análisis bivariado para establecer la asociación de las variables independientes frente a la dependiente y, posteriormente, un análisis multivariado. Las variables cualitativas se presentan como proporciones y las cuantitativas mediante medidas de tendencia central y dispersión. El departamento del Quindío emplea la guía de práctica clínica del Ministerio de Salud del año 2014 para el diagnóstico, enfoque y tratamiento de sífilis gestacional y congénita. Para el año 2022, según lo reportado en el boletín epidemiológico de la semana 35 por el Ministerio de Salud y Protección Social, el departamento del Quindío superó la incidencia nacional en casos de sífilis congénita con una tasa de incidencia de 3.3 por 1000 nacidos vivos.
Resultados: Se realizó un modelo de regresión logística binaria, encontrando que las variables ingresadas al modelo, al estar presentes en la población materna, explican la probabilidad del 28.2% de desarrollo de sífilis congénita.
Conclusiones: De acuerdo con los resultados obtenidos en este estudio, se encontró una asociación débil entre las variables sociodemográficas de las gestantes; sin embargo, las variables clínicas pueden tener asociación, como era de esperar de acuerdo con el diagnóstico.
Síndrome de interrupción del tallo hipofisario: reporte de caso y revisión de la literatura de una paciente con diagnóstico tardío.
Authors: Mendoza-Borja Karolay , Ramos-Noriega Sofía , Aguilar-Britto Ericka , Guerrero-Roa Wendy , García-Bermejo Roberto 
Published: January 2024

Antecedentes: El síndrome de interrupción del tallo hipofisario (SITH) hace referencia a un defecto congénito de etiología poco clara, caracterizado por: tallo hipofisario delgado o interrumpido, lóbulo hipofisiario posterior ausente o ectópico y lóbulo anterior hipoplásico o aplásico. Su presentación clínica se relaciona con los grados variables de deficiencias hormonales hipofisiarias (pan-hipopituitarismo), destacando el déficit de hormona de crecimiento, hipotiroidismo e hipo-cortisolismo por déficit de hormona adreno-corticotropa. Algunos casos se diagnostican tardíamente.
Reporte de caso: Paciente femenina que presentó en su nacimiento cuadros de hipoglucemia recurrente e ictericia neonatal, acompañado de crisis neonatales, con diagnóstico tardío de SITH, realizado a los 4 años de vida. Los exámenes hormonales reportaron hipo-cortisolemia, déficit de hormona de crecimiento e hipotiroidismo central; y la resonancia magnética de hipófisis informó hipoplasia hipofisiaria, neurohipófisis ectópica y tallo hipofisiario interrumpido. Recibe suplencia hormonal con somatropina humana, levotiroxina e hidrocortisona, con buena respuesta clínica luego del diagnóstico e inicio de tratamiento.
Conclusión: El diagnóstico temprano del SITH puede evitar a largo plazo problemas principalmente relacionados al metabolismo, estrés, crecimiento y desarrollo. La realización de una imagen por resonancia magnética de hipófisis, es la clave para la realización del diagnóstico.
Boundary regularity results for minimisers of convex functionals with (p, q)-growth
Authors: Irving Christopher , Koch Lukas 
Published: January 2024

Abstract
We prove improved differentiability results for relaxed minimisers of vectorial convex functionals with

(

p
,
q

)

\left(p,q)

-growth, satisfying a Hölder-growth condition in

x

x

. We consider both Dirichlet and Neumann boundary data. In addition, we obtain a characterisation of regular boundary points for such minimisers. In particular, in case of homogeneous boundary conditions, this allows us to deduce partial boundary regularity of relaxed minimisers on smooth domains for radial integrands. We also obtain some partial boundary regularity results for non-homogeneous Neumann boundary conditions.
Constitutive and evoked release of ATP in adult mouse olfactory epithelium
Authors: Hayoz Sébastien , Jia Cuihong , Hegg Colleen Cosgrove 
Published: January 2024

Abstract
In adult olfactory epithelium (OE), ATP plays a role in constant cell turnover and post-injury neuroregeneration. We previously demonstrated that constitutive and ATP-evoked ATP release are present in neonatal mouse OE and underlie continuous cell turn-over and post-injury neuroregeneration, and that activation of purinergic P2X7 receptors is involved in the evoked release. We hypothesized that both releases are present in adult mouse OE. To study the putative contribution of olfactory sensory neurons to ATP release, we used olfactory sensory neuronal-like OP6 cells derived from the embryonic olfactory placode cells. Calcium imaging showed that OP6 cells and primary adult OE cell cultures express functional purinergic receptors. We monitored ATP release from OP6 cells and whole adult OE turbinates using HEK cells as biosensors and luciferin–luciferase assays. Constitutive ATP release occurs in OP6 cells and whole adult mouse OE turbinates, and P2X7 receptors mediated evoked ATP release occurs only in turbinates. The mechanisms of ATP release described in the present study might underlie the constant cell turn-over and post-injury neuroregeneration present in adult OE and thus, further studies of these mechanisms are warranted as it will improve our knowledge of OE tissue homeostasis and post-injury regeneration.