bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal behavior is reversible in a chromatin mutant
Authors: Rodriguez Juan D. , Reeves Monica N. , Wang Hsiao-Lin V. , Chavez Jaely Z. , Rastogi Rhea , Chavez Sindy R. , Preston Elicia A , Chadha Madhav S. , Sun Liyang , Hill Emily J. , Corces Victor G. , Schmeichel Karen L. , Murray John I. , Katz David J. 
Published: November 2023

AbstractHow mutations in histone modifying enzymes lead to neurodevelopmental disorders is unknown. We took advantage of the invariant embryonic lineage and adult nervous system inC. elegansto investigate a double mutant betweenspr-5/Lsd1/Kdm1a(H3K4me1/2 demethylase) andmet-2/Setdb1(H3K9 methyltransferase). We demonstrate thatspr-5; met-2double mutant worms have a severe chemotaxis defect caused by the ectopic expression of germline genes in somatic tissues. Despite this behavioral defect, we observe few embryonic lineage alterations and an intact adult nervous system. This raises the possibility that the abnormal chemotaxis behavior may be due to ongoing defects in terminally differentiated cells rather than alterations in development. Remarkably, we found that shutting off the ectopic germline expression rescues normal chemotaxis in the samespr-5; met-2adult worms that had a chemotaxis defect earlier. This suggests that ongoing inappropriate transcription can block normal behavior in an intact nervous system. Based on these data, it is possible that the intellectual disability and altered behavior observed in human neurodevelopmental syndromes caused by mutations in histone modifying enzymes could be due to ongoing ectopic transcription and may be reversible.
Impact of acute chlorpyrifos toxicity on the histology and biochemistry of the stomach, intestine, and muscle of theAnabas testudineus
Authors: Sudhakaran Bindu Vijayakumari , Sreeja S 
Published: November 2023

AbstractChlorpyrifos is classified as an organophosphorus pesticide that exhibits properties of being a broad-spectrum insecticide, acaricide, and nematicide. It is characterized by its ability to degrade quickly and its non-persistent nature. The current investigation involved the determination of the LC50value of chlorpyrifos onA. testudineus. The computed LC50values were found to be 11.59, 8.82, 6.30, and 3.82 ppm for exposure durations of 24, 48, 72, and 96 hours, respectively. The levels of protein and glycogen in the stomach, gut, and muscle of A. testudineus, which were subjected to a concentration of 3.82 ppm (LC5096 hours) chlorpyrifos for a duration of 96 hours, exhibited a notable reduction when compared to the control group. The stomach sections of A. testudineus, when subjected to a concentration of 3.82 ppm chlorpyrifos for a duration of 96 hours, exhibited degeneration of the mucosa layer and necrosis of the mucosa epithelium. The histopathological examination of the intestine revealed several notable findings, including the presence of a disintegrating serosa, a significantly enlarged muscularis layer, and observable damage to both the circular muscle layer and submucosa. Additionally, evidence of necrosis was observed within the mucosa layer. The muscle tissue exhibited degeneration inside the muscle bundles, characterized by the presence of discrete regions of necrosis and the development of vacuoles within the muscle bundles. The results of this study demonstrate that chlorpyrifos exhibits a significant level of toxicity towards A. testudineus, and it is important to note that the absence of mortality does not guarantee the maintenance of physiological well-being in this particular fish species.
Human CD127 negative ILC2s show immunological memory
Authors: Mathä Laura , Krabbendam Lisette , Martinez-Høyer Sergio , Heesters Balthasar , Golebski Kornel , Kradolfer Chantal M.A , Ghaedi Maryam , Ma Junjie , Stadhouders Ralph , Bachert Claus , Cardell Lars O. , Nan Zhang , Holtappels Gabriele , Helgers Leanne C. , Geijtenbeek Theo B.H , Coquet Jonathan M. , Takei Fumio , Spits Hergen , Martinez-Gonzalez Itziar 
Published: November 2023

SUMMARYGroup 2 Innate Lymphoid Cells (ILC2s) serve as key players in type 2 immunity and contribute significantly to maintaining homeostasis and responding to inflammation. Notably, ILC2s are closely implicated in the development of allergic disorders like asthma. While previous research has demonstrated immunological memory in mouse ILC2s, it has remained unclear whether human ILC2s can acquire this form of memory. In this study, we demonstrate the persistence of CD45RO, a marker previously linked to inflammatory ILC2s, in resting ILC2s that have undergone prior activation. These cells concurrently reduce the expression of the canonical ILC marker CD127. Through in vitro experiments involving the isolation and stimulation of CD127-CD45RO+ ILC2s, we observed an augmented ability to produce cytokines and undergo proliferation. CD127-CD45RO+ ILC2s are found in both healthy and inflamed tissues and display a gene signature of cell activation. Memory ILC2s may play a significant role in chronic type 2 diseases, such as allergic asthma and atopic dermatitis.HIGHLIGHTS– Inflamed and healthy tissues contain CD127-ILC2s with a gene signature of cell activation– CD127-CD45RO+ ILC2s from healthy tissues show immunological memory features– Mouse memory ILC2s downregulate CD127– In vitro stimulation of naïve ILC2s generates memory CD127-CD45RO+ ILC2s
Role of finger movement kinematics in friction perception at initial contact with smooth surfaces
Authors: Afzal Naqash , Dunilac Sophie du Bois de , Loutit Alastair J. , Shea Helen O , Martinez Ulloa Pablo , Khamis Heba , Vickery Richard M. , Wiertlewski Michaël , Redmond Stephen J. , Birznieks Ingvars 
Published: November 2023

AbstractWhen manipulating objects, humans adjust grip force to friction remarkably quickly: it may take just 100 ms to see adjustment to friction at the skin-object interface. While the motor commands adapt, subjects become aware of slipperiness of touched surfaces. In this study, we explore the sensory processes underlying such friction perception when no intentional exploratory sliding movements are present. Previously, we have demonstrated that humans cannot perceive frictional differences when surfaces are brought in contact with an immobilized finger (Khamis et al., 2021b) unless there is a submillimeter lateral displacement (Afzal et al., 2022), or subjects made the movement themselves (Willemet et al., 2021). In the current study, subjects actively interacted with a device that can modulate friction using ultrasound, without an exploratory sliding movement, as they would when gripping an object to lift it. Using a two-alternative forced-choice paradigm, subjects had to indicate which of two surfaces felt more slippery. Subjects could correctly identify the more slippery surface in 87 ± 8% of cases (mean±SD; n=12). Biomechanical analysis of finger pad skin contacting a flat smooth surface indicated that natural movement kinematics (e.g., tangential movement jitter and physiological tremor) may enhance perception of frictional effects. To test whether this is the case, in a second experiment a hand support was introduced to limit fingertip movement deviation from a straight path. Subject performance significantly decreased (66 ± 12% correct, mean±SD; n=12), indicating that friction perception at the initial contact is enhanced or enabled by natural movement kinematics.Significance statementSensing surface friction is crucial for automatic grip force control to avoid dropping objects. A slipping handhold can lead to loss of balance and falling. In many instances, the required grip force may exceed hand’s physical ability or an object’s breakage point, therefore cognitive selection of a safe and achievable action plan based on friction perception is critical. Little is known about how our awareness of surface slipperiness is obtained under such circumstances without exploratory movement. The current study demonstrates that natural movement kinematics inducing submillimeter lateral movements play a central enabling role, demonstrating interdependence between the motor system and sensory mechanisms. These findings broaden our fundamental understanding of sensorimotor control and could inform the development of advanced sensor technologies.
Using a hybrid methodology for literature review: a case study in depression research
Authors: Abdallah Salam , Khalil Ashraf 
Published: November 2023

Purpose
This study aims to understand and a lay a foundation of how analytics has been used in depression management, this study conducts a systematic literature review using two techniques – text mining and manual review. The proposed methodology would aid researchers in identifying key concepts and research gaps, which in turn, will help them to establish the theoretical background supporting their empirical research objective.

Design/methodology/approach
This paper explores a hybrid methodology for literature review (HMLR), using text mining prior to systematic manual review.

Findings
The proposed rapid methodology is an effective tool to automate and speed up the process required to identify key and emerging concepts and research gaps in any specific research domain while conducting a systematic literature review. It assists in populating a research knowledge graph that does not reach all semantic depths of the examined domain yet provides some science-specific structure.

Originality/value
This study presents a new methodology for conducting a literature review for empirical research articles. This study has explored an “HMLR” that combines text mining and manual systematic literature review. Depending on the purpose of the research, these two techniques can be used in tandem to undertake a comprehensive literature review, by combining pieces of complex textual data together and revealing areas where research might be lacking.
Forecasting turnover intention: an analysis of psychological factors and perceived organizational support among healthcare professionals
Authors: Abdelwahed Nadia A. Abdelmegeed , Al Doghan Mohammed A. , Saraih Ummi Naiemah , Soomro Bahadur Ali 
Published: November 2023

Purpose
Turnover intention (TOI) has become a severe issue in Saudi Arabia’s health-care system as health professionals leave their organizations. Saudi Arabia’s health-care professionals’ TOI affects the organizations and the patients’ human rights. Therefore, this study aims to assess the factors that affected Saudi Arabia’s health-care professionals’ TOI.

Design/methodology/approach
This study based its findings on quantitative cross-sectional data. This study’s respondents were health-care professionals working in Saudi Arabia’s public and private health-care institutions.

Findings
By using path analysis, this study’s findings reveal that, on the one hand, job stress (JS), psychological distress (PD) and perceived work exhaustion (PWE) have positive and significant effects on TOI. On the other hand, perceived organizational support (POS) is a positive and significant predictor of TOI.

Practical implications
This study’s findings will help the Saudi Arabian Ministry and policymakers develop policies to encourage health professionals’ perseverance through reducing their JS, PD and PWE and by enhancing POS for health-care staff. Moreover, by controlling the increasing turnover ratio among Saudi Arabia’s health-care professionals, this study’s findings assist in overcoming the violations of human rights.

Originality/value
This study’s findings empirically confirm the development of TOI through JS, PD and PWE among Saudi Arabia’s health-care professionals.
Fatal structure fire classification from building fire data using machine learning
Authors: Balakrishnan Vimala , Mohammed Hashim Aainaa Nadia , Lee Voon Chung , Lee Voon Hee , Lee Ying Qiu 
Published: November 2023

PurposeThis study aims to develop a machine learning model to detect structure fire fatalities using a dataset comprising 11,341 cases from 2011 to 2019.Design/methodology/approachExploratory data analysis (EDA) was conducted prior to modelling, in which ten machine learning models were experimented with.FindingsThe main fatal structure fire risk factors were fires originating from bedrooms, living areas and the cooking/dining areas. The highest fatality rate (20.69%) was reported for fires ignited due to bedding (23.43%), despite a low fire incident rate (3.50%). Using 21 structure fire features, Random Forest (RF) yielded the best detection performance with 86% accuracy, followed by Decision Tree (DT) with bagging (accuracy = 84.7%).Research limitations/practical implicationsLimitations of the study are pertaining to data quality and grouping of categories in the data pre-processing stage, which could affect the performance of the models.Originality/valueThe study is the first of its kind to manipulate risk factors to detect fatal structure classification, particularly focussing on structure fire fatalities. Most of the previous studies examined the importance of fire risk factors and their relationship to the fire risk level.
Understanding interdependency of sustainability dimensions from the lens of collaborative relationship conditions: findings from an emerging economy
Authors: Kumar Gopal , Zacharia Zach G. , Goswami Mohit 
Published: November 2023

PurposeDrawing on the relational view and contingency theories, this study explores supply chain relationship conditions' roles in interrelationships between environmental, social and supply chain performance (SCP), i.e. triple bottom line (TBL).Design/methodology/approachThe data from industries and structural equation modeling (SEM) were used to validate the proposed model. Interviews with industry experts were conducted to further understand the findings.FindingsThe authors find that relationship conditions, such as inventory information sharing, dependency, opportunistic behavior and conflicts, moderate TBL linkages. Interestingly, power asymmetry does not moderate the linkages. Social performance mediates between environmental and SCP. This indirect effect is stronger than the effect of environmental performance on SCP.Originality/valueThis research is perhaps the first to bring a much-needed nuanced view on the importance of relationship conditions for TBL performance linkages. The research further underlines the importance of social performance in an emerging economy.
Tourism recovery: exploring the impact of residents' animosity on attitudes, intentions and behaviours to support tourism development
Authors: Moghavvemi Sedigheh , Hassani Ali , Woosnam Kyle M. , Abdrakhmanova Saniya , Jiang Chunyu 
Published: November 2023

PurposeThis study aims to explore the most salient contributors to residents' support for tourism. As such, the authors measure residents' fear and risk of coronavirus disease 2019 (COVID-19) and residents' animosity towards tourists as predictors of attitudinal, intentional and behavioural support for tourism in China, Malaysia, Kazakhstan and Iran.Design/methodology/approachAn online survey of 1,318 respondents across four countries was conducted, with data analysed using structural equation modelling.FindingsThis study shows that residents' perceptions about tourism development vary in different countries based on the impact of COVID-19, even though some factors, such as perceived risk and fear of COVID-19, have a similar effect on residents' attitudes and intentions to support tourism.Research limitations/implicationsOnly residents from four countries participated due to the collaborative effort of researchers from these specific countries.Practical implicationsInsight into residents' perceptions and responses to COVID-19 can aid policymakers and managers in developing effective crisis recovery strategies.Social implicationsThe data from this study can serve as a foundation for future research to examine residents' attitudes and support towards tourism during the post-COVID-19 period.Originality/valueUnlocking the unrevealing of residents' perceptions and coping mechanisms towards tourists during the pandemic, this research shines a light on their crucial role in the revival of the tourism industry. With an exclusive focus on residents' attitudes and behaviours, this study stands out amongst the few that delve into this crucial aspect of post-pandemic recovery.
An artificial bee colony algorithm for medical goods distribution and pharmacological waste collection by hybrid vehicles considering environmental criteria
Authors: Behnamian Javad , Kiani Z. 
Published: November 2023

Purpose
This paper aims to focus on a medical goods distribution problem and pharmacological waste collection by plug-in hybrid vehicles with some real-world restrictions. In this research, considering alternative energy sources and simultaneous pickup and delivery led to a decrease in greenhouse gas emissions and distribution costs, respectively.

Design/methodology/approach
Here, this problem has been modeled as mixed-integer linear programming with the traveling and energy consumption costs objective function. The GAMS was used for model-solving in small-size instances. Because the problem in this research is an NP-hard problem and solving real-size problems in a reasonable time is impossible, in this study, the artificial bee colony algorithm is used.

Findings
Then, the algorithm results are compared with a simulated annealing algorithm that recently was proposed in the literature. Finally, the results obtained from the exact solution and metaheuristic algorithms are compared, analyzed and reported. The results showed that the artificial bee colony algorithm has a good performance.

Originality/value
In this paper, medical goods distribution with pharmacological waste collection is studied. The paper was focused on plug-in hybrid vehicles with simultaneous pickup and delivery. The problem was modeled with environmental criteria. The traveling and energy consumption costs are considered as an objective function.
Training orientation, organizational support and training satisfaction – the mediating role of perceived value of training
Authors: To Wai Ming , Leung Vincent W.S. 
Published: November 2023

Purpose
This study aims to explore the relationships between employees’ training orientation, organizational support for training and employees’ training satisfaction. It also investigates the mediating role of perceived value of training in the relationships.

Design/methodology/approach
Based on a literature review on training, the study proposes a theoretical model that links employees’ training orientation and organizational support for training to training satisfaction directly and indirectly via perceived value of training, while employees’ training satisfaction may influence affective commitment. The model was tested using responses from 364 Chinese employees in Macao.

Findings
Results of partial least square-structural equation modeling showed that employees’ training orientation influenced training satisfaction directly and indirectly through perceived value of training, while organizational support for training also influenced employees’ training satisfaction indirectly through perceived value of training. Training satisfaction had a positive effect on affective commitment.

Research limitations/implications
The study’s limitations include a cross-sectional design and the characteristics of Macao’s economic structure. Although the causality of relationships was grounded in prior studies, reverse relationships might exist between some selected variables. It is suggested that a longitudinal study shall be carried out to confirm the causality of relationships. Additionally, Macao’s economy is dominated by its service sector. Future research can be carried out in other cities that have the manufacturing and high-technology sectors.

Originality/value
The study unveiled that employees’ training orientation including their general attitude towards training and training goal orientation and organizational support for training are key antecedents of training satisfaction. Human resources professionals in organizations must develop innovative ways, such as simulation games and competitions, to enhance the awareness of the importance of training to their employees. Additionally, they must advocate and demonstrate organizations providing supportive environments for training.
External audit quality, auditor selection and hostile takeovers: evidence from half a century
Authors: Boonlert-u-thai Kriengkrai , Chatjuthamard Pattanaporn , Papangkorn Suwongrat , Jiraporn Pornsit 
Published: November 2023

PurposeExploiting a unique measure of hostile takeover exposure principally based on the staggered adoption of state legislations, the authors investigate how external audit quality is influenced by the discipline of the takeover market. External auditors and the takeover market both function as important instruments of external corporate governance.Design/methodology/approachThe authors execute a standard regression analysis and run a variety of robustness checks to minimize endogeneity, namely, propensity score matching (PSM), entropy balancing, an instrumental-variable analysis, Generalized method of moment (GMM) dynamic panel data analysis and Lewbel's (2012) heteroscedastic identification.FindingsThe authors’ immense sample spans half a century, encompassing nearly 180,000 observations and 17 takeover-related state legislations, one of the largest samples in the literature in this area. The authors’ results suggest that firms with more takeover exposure are significantly less likely to use Big N auditors. Therefore, a more active takeover market results in poorer external audit quality, corroborating the substitution hypothesis. The discipline of the takeover market substitutes for the necessity for a high-quality external auditor. Specifically, a rise in takeover susceptibility by one standard deviation lowers the probability of using a Big N auditor by 4.29%.Originality/valueThe authors’ study is the first to examine the effect of the takeover over market on audit quality using a novel measure of hostile takeover susceptibility mainly based on the staggered implementation of state legislation. Because the enactment of state legislation is beyond the control of any firm individually, it is plausibly exogenous. The authors’ results therefore probably reflect a causal influence rather than merely a correlation.
Developing new understanding of how global talent flow impact individual and firm performance by using big data
Authors: Baruch Yehuda , Guttormsen David S. A. , Gyoshev Stanley B. , Pavkov Trifon , Plesca Miana 
Published: November 2023

AbstractDrawing on human capital theory, we explore the impact of global mobility on individuals and their employing firms. We also investigate the role of cultural distance between workers who move across country borders and the local culture, and the role that HRM may play to improve capitalizing on global talent mobility. We use a big data set comprising the entire population in one country, including about 30,000 expatriates from 143 countries employed by 15,000 firms, over 11 years of data covering about 100,000 observations on expatriates and 80,000 on their firms. Our findings support the existence of positive impact of global firms on performance (6.7% higher revenues after labor costs) and individuals' wages (10%–20% higher salaries). Both relationships are statistically and economically significantly influenced by cultural distance for the performance of global firms, leading to HRM implications.