bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Risankizumab Compared with Apremilast in Patients with Moderate Plaque Psoriasis: Mean PASI and BSA Results From the Phase 4 IMMpulse Trial
Authors: Stein Gold Linda , Bagel Jerry , Tyring Stephen Keith , Hong Chih-ho , Pavlovsky Lev , Pinter Andreas , Reich Adam , Drogaris Leonidas , Wu Tianshuang , Photowala Huzefa , Stakias Vassilis , Richter Sven , Papp Kim 
Published: November 2023

Introduction
The IMMpulse study (NCT04908475) demonstrated superior efficacy of risankizumab (RZB) compared to apremilast (APR) in systemic-eligible patients with moderate plaque psoriasis (PsO).
Material and Methods
This phase 4, multi-center, randomized, open-label, assessor-blinded, active comparator study compared RZB to APR in adult systemic-eligible patients with moderate plaque PsO. In period A, patients were randomized 1:2 to receive RZB (150 mg) or APR (30 mg twice daily) for 16 weeks. In period B, all APR-treated patients were re-randomized 1:1 to RZB or APR stratified by their ≥ 75% improvement in psoriasis area and severity index (PASI75) response. All RZB patients in period A continued treatment till week 52. Pre-specified efficacy endpoints included change in PASI and body surface area (BSA) from baseline. Continuous endpoints were assessed using mixed-effect model repeat measures to handle missing data.
Results
Baseline characteristics were similar between the treatment arms. At week 16, PASI75 was achieved by 84.7% (RZB-treated) and 18.8% (APR-treated) patients. Mean PASI improved from 14.6 at baseline to 1.7 (RZB-treated), and from 14.5 at baseline to 8.8 (APR-treated) patients. Mean BSA improved from 13.1% to 2.6% with RZB, and from 13.1% to 10.6% for APR-treated patients. APR-treated patients not achieving PASI75 at week 16 who switched to RZB achieved a mean PASI of 0.7 at week 52, compared to 3.1 at week 52 in patients who continued with APR. In these same patients, those that switched to RZB achieved a mean BSA of 1.4% at week 52 compared to 6.3% for patients who continued APR. Most frequently observed treatment emergent adverse events were COVID-19 and nasopharyngitis for RZB, and diarrhea, nausea, and headache for APR.
Conclusions
These results demonstrate minimal residual disease observed with continuous RZB treatment and support the opportunity to elevate treatment outcomes with RZB in systemic-eligible patients with moderate plaque PsO.
Safety and Tolerability of Tirbanibulin 1% Treatment of Actinic Keratosis on Face and Scalp in Routine Clinical Practice Across the U.S. (PROAK Study)
Authors: Schlesinger Todd , Lebwohl Mark , Del Rosso James , Patel Vishal A. , Kircik Leon , Armstrong April , Berman Brian , Rigel Darrell , Narayanan Siva , Koscielny Volker , Kasujee Ismail , Bhatia Neal 
Published: November 2023

Introduction: Actinic Keratosis (AK) has been shown to negatively affect emotional and social functioning and skin-related quality of life of patients [1]. The objective of this analysis was to evaluate safety and tolerability of tirbanibulin in AK treatment, among patients administered tirbanibulin in routine clinical practice across the U.S.
Methods: A single-arm, multicenter, prospective cohort study (PROAK: NCT05260073) was conducted in adult patients with AKs on 25 cm2 on the face or scalp who were newly initiated with once-daily tirbanibulin 1% ointment treatment (5 consecutive days course) as part of usual care. Safety and tolerability endpoints were assessed at Week-8 and Week-24 and included adverse events (AEs), serious AEs (SAE), adverse drug reactions (ADRs), serious ADRs, local skin reactions (LSR), skin scarring and pigmentation (hypo/hyperpigmentation). Number of patients discontinuing treatment because of AEs, ADRs and for any other reasons were also reported. LSR (erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation, and erosion/ulceration) were scored 0-3 (absent-severe) and summed to a composite score (0-18).
Results: A total of 300 patients were included in the safety analysis population (males: 68%; mean age: 67 years; Fitzpatrick skin type II: 89%; AK on the face: 78%). A total of 98% of patients completed the 5-day treatment course. During the study, 5% of patients reported at least one AE, 4% of patients at least 1 SAE, and no patients reported serious ADR. Basal Cell Carcinoma was reported in 1% of patients and Squamous Cell Carcinoma in 2% of patients; all cases were considered not related to treatment. No patients discontinued the study due to AEs or ADRs. At Week-8, the most reported LSR were erythema (48% mild-moderate, 5% severe) and flaking/scaling (50% mild-moderate, 3% severe). The rest of LSR were reported in 2-8% of patients (8% crusting, 5% swelling, 2% vesiculation/pustulation, and 2% erosion/ulceration) and all were mild-moderate in severity. Mean (min-max) LSR composite score was 0.94 (0-11). At Week-8, scarring or hypo/hyperpigmentation was observed in 1%, 5% and 3% of patients, respectively.
Conclusions: Once-daily tirbanibulin 1% ointment for 5 consecutive days showed a favorable safety and tolerability profile in the treatment of AK of the face or scalp.
[1] Schlesinger T et al. Skin. 2023;7(3):771-787.
Distribution of SALT scores by Therapeutic Tesponse in Patients with Severe Alopecia After 52 weeks of Baricitinib Therapy
Authors: Atanaskova Natasha , Senna Maryanne , Mostaghimi Arash , Seneschal Julien , McMichael Amy , Somani Najwa , Lu Na , Zou Jianxiang , Jedynak Jakub , Torisu-Itakura Hitoe , Shapiro Jerry 
Published: November 2023

Introduction: In pivotal BRAVE-AA1 and AA2 phase 3 clinical trials, the Janus kinase (JAK)1/JAK2 inhibitor baricitinib has demonstrated efficacy in achieving clinically meaningful regrowth of hair in patients with severe alopecia areata. While a significant proportion of patients achieve regrowth by weeks 36 and 52 on baricitinib versus placebo, other patients, particularly those with longer episode duration or with higher disease severity, require more time on therapy to see full treatment benefit. The treatment benefit and distribution of SALT scores at Week 52 across the spectrum of responders is reported here.
Methods: Adults with Severity of Alopecia Tool (SALT) score ≥50 (≥50% scalp hair loss) were enrolled into BRAVE-AA1 and BRAVE-AA2. Patients were randomized 2:2:3 to receive once-daily placebo (N=345), baricitinib 2 mg (BARI-2MG) (N=340), or baricitinib 4 mg (BARI-4MG) (N=515). Patients randomized to baricitinib retained their treatment allocation through Week 52. Pooled outcomes were assessed by baricitinib group and in patients with SALT score ≤20 versus SALT score >20 at Week 52. Median and interquartile range (IQR) of SALT scores was assessed with last observation carried forward.
Results: At baseline, the median SALT score across 1200 randomized patients was 96 (near-total hair loss), with 638 (53.2%) having SALT score 95-100. At Week 52, 24.1% of patients who received BARI-2MG and 41.6% of patients who received BARI-4MG had SALT score ≤20; median (IQR) absolute SALT scores in this group were 7 (1-12) with BARI-2MG treatment and 3 (0-11) with BARI-4MG treatment. 17.9% of patients who received BARI-2MG and 18.8% of patients who received BARI-4MG patients achieved SALT scores of 21-49 at Week 52; median (IQR) scores were 34 (27-41) following BARI-2MG treatment and 31 (26-42) following BARI-4MG treatment.
Conclusions: While a significant proportion of patients achieved SALT ≤20, the findings of this analysis indicate that partial benefit across scalp hair regrowth is achieved even if patients do not meet clinical response criteria of SALT ≤20. There is a substantial proportion of patients who demonstrate movement towards improvement across the SALT score spectrum. In these patients, a longer treatment course may be necessary to achieve optimal treatment outcomes.
Funded by Eli Lilly and Company.
ОПРЕДЕЛЕНИЕ ОПТИМАЛЬНЫХ ПАРАМЕТРОВ ВЛИЯНИЯ УФО НА ОЖИВЛЕНИЕ ГРЕНЫ ТУТОВОГО ШЕЛКОПРЯДА
Authors: Исматуллаева Д.А. , Азимова Д.А.к. 
Published: November 2023

Получен расчет необходимых оптимальных параметров использования лампы и облучателя грены (яйца) тутового шелкопряда для получения энергии излучения. Можно заметить, что грена тутового шелкопряда, которую облучали УФО разными параметрами, стимулировало зародыш внутри грены и повысило процент оживляемости. В результате мы наблюдали повышенную оживляемость грены в некоторых опытных вариантах по сравнению с контролем. Среди 81 различных вариантов эксперимента наибольший процент оживляемости составил 99,5% при использовании ламп УФО 254 нм мощностью 90 Вт и УФО 300 нм мощностью 30 Вт в течение 5 минут на расстоянии 10 см, и 99,1% при лампе УФО 254 нм мощностью 60 Вт и УФО 300 нм мощностью 30 Вт использовались в течение 30 продемонстрированных при использовании в течение 3 минут на расстоянии 30 см (сравнительный показатель 95,5%). Также есть варианты, которые показывают низкий показатель в сочетании подсветки. Это 95,3 % УФО 254 нм 30 Вт и УФО 300 нм 30 Вт лампы на расстоянии 10 см в течение 1 минуты, 95,0 % УФО 254 нм 60 Вт и УФО 300 нм 30 Вт лампы на расстоянии 20 см в течение 5 минут, 95,4 % УФО 254 нм 90 Вт и УФО 300 нм 30 Вт лампы на расстоянии 20 см в течение 3 минут и УБН 254 нм 30 Вт и 95,0 % УФО 300 нм 30 Вт лампы на расстоянии 30 см за 3 минуты показали низкий процент оживления (по сравнению с контролем - 95,5 %).
The calculation of the necessary optimal parameters for the use of the lamp and the irradiator of the mulberry silkworm (egg) to obtain radiation energy is obtained. It can be noted that the silkworm’s egg, which was irradiated with DEA with different parameters, stimulated the embryo inside the egg and increased the percentage of livability. As a result, we observed an increased revivability of the egg in some experimental variants compared to the control. Among 81 different variants of the experiment, the highest percentage of livability was 99,5 % when using DEA 254 nm lamps with a power of 90 Wand DEA 300 nm with a power of 30 W for 5 minutes at a distance of10 cm, and 99,1 % when DEA 254 nm lamps with a power of 60 W and DEA 300 nm with a power of 30 W were used for 30 demonstrated use for 3 minutes at a distance of 30 cm (a comparative indicator of 95,5 %). There are also options that show a low indicator in a combination of illumination. These are 95,3 % DEA 254 nm 30 W and DEA 300 nm 30 W lamps at a distance of 10 cm for 1 minute, 95,0 % DEA 254 nm 60 W and DEA 300 nm 30 W lamps at a distance of 20 cm for 5 minutes, 95.4% DEA 254 nm 90 W and DEA 300 nm 30 W lamps at a distance of 20 cm for 3 minutes and DEA 254 nm 30 W and 95.0% DEA 300 nm 30 W lamps at a distance of 30 cm for 3 minutes showed a low percentage of recovery (compared to the control - 95,5 %).
La dialyse péritonéale en République du Congo : historique et problématique actuelle (lettre)
Authors: Gandzali Ngabee Eric , Kambourou Judicael , Okiemy Cardinal , Eyeni Sinomono Tony Daniel , Mahoungou Gael , Loumingou Richard 
Published: November 2023

Introduction
La dialyse péritonéale (DP) est une technique d'épuration extrarénale utilisant le péritoine comme membrane d'échange.
Les objectifs de ce travail étaient de faire l'historique de la dialyse péritonéale au Congo Brazzaville et de décrire une technique de cathétérisme pour la dialyse péritonéale à l'aide de la sonde nasogastrique en l’absence de disponibilité de cathéter spécifique pour DP.
Méthode
Nous avons passé en revue la littérature sur la DP en République du Congo et décrit la technique actuelle.
Résultats
Notre revue de la littérature sur la DP au Congo révèle que la première DP en République du Congo a été réalisée en 1989 par MPIO et ses collègues. Notre technique actuelle de DP n'utilise qu'une sonde nasogastrique placée en sous-ombilical par un chirurgien pédiatre sous anesthésie locale, et un dialysat de fabrication locale perfusé à la dose de 50ml par kilogramme et par jour d'un mélange de ringer lactate et de sérum glucosé hypertonique avec 1 ampoule de sérum glucosé hypertonique à 30% ou d'icodextrine en cas d'œdème aigu du poumon (OAP). Sur les 6 patients qui ont bénéficié de la DP, 2 se sont rétablis.
Conclusion
La description de la technique de DP révèle que n'importe quel pays en développement peut le faire. Nos résultats globaux encouragent la poursuite de la DP et motivent la création d'une unité de DP au CHU/B.
Efficiency evaluating method for coordinated control type on main street
Authors: Dorokhin S. V. , Artemov A. Yu. 
Published: November 2023

For the majority of cities with an established transport system, certain intensity fluctuations are characteristic, which are cyclical and repeated during a day, day and night and week. Taking into account the available equipment, executive elements of the first layer of intelligent transportation systems (ITS), it is possible to promptly assess the transportation situation and change the mode of control in the on-line format, but this kind of technology is mainly presented in large cities. In spite of the fact that in cities with a small population, belonging to the category of small and medium-sized cities there are identical problems in the field of coordinated management of main streets, on such sections there is no possibility of operational change of management, due to the lack of special equipment and implementation of constant monitoring and control of the traffic situation. In order to improve the efficiency of management in such sections located in small and medium-sized cities, it is necessary to develop a way to evaluate the effectiveness of coordinated management, which is the main purpose of the study.Methods and materials. As a result of the performed research, methods of field observations, calculation methods and modelling methods were used.Results. As part of the completed study, a method to evaluate the effectiveness of the coordinated type of control based on a comparison of the average intensity of the adjacent and mainline section and their corresponding average delay values was developed.Conclusion. The use of the obtained results on the research object made possible to establish time periods of application of coordination and rigid non-coordinated control.
Organizational and technological reliability of construction in Iraq
Authors: Al-Msari Ahmed Abdul Ruda Awda , Rudenko A. A. 
Published: November 2023

Introduction. The construction of capital construction facilities is a complex organizational and technological task, providing for the execution of a complex of construction and installation works, as well as organizational and technological interaction of all construction participants, including with the aim of prompt management of risks arising during construction with varying degrees of intensity and danger.Materials and methods. One of the main conditions for ensuring organizational and technological reliability in the construction industry is the full and timely provision of all types of resources, which at the current stage is not always an effectively solved scientific and practical task, due to the high level of various risks.Results. The results of the adverse consequences of the risks have a very negative and significant impact on such construction issues as compliance with the deadlines for the work, optimization of the cost of the facility at all stages of its construction, ensuring the specified quality of construction and installation. In this regard, ensuring organizational and technological reliability (OTR) of construction based on an effective resource support system, taking into account risks, is an urgent and important task.Discussion and conclusion. Consideration of the impact of construction resource supply factors is important for taking into account the risk and its consequences, as a quantitative measure to assess the negative or favorable scenario of construction progress. Assessment of various factors of resource supply will make it possible to more accurately assess the organizational and technological reliability of construction.
IMPLEMENTASI MANAJEMEN PEMUTUSAN HUBUNGAN KERJA (PHK) TERHADAP PEKERJA STATUS PERJANJIAN KERJA WAKTU TIDAK TERTENTU (PKWTT) DI AL-HASYIMIYAH BOUTIQUE STORE
Authors: Fahrudin Fahrudin , Sunaika Sunaika , Mawaddah Ida 
Published: November 2023

<p>Penelitian ini membahas mengenai Pemutusan Hubungan Kerja (PHK) adalah pemutusan hubungan kerja yang dilakukan oleh pekerja dan pemberi kerja disebabkan karena suatu hal tertentu dan mengakibatkan berakhirnya kontrak kerja atau hak dan kewajiban pekerja tersebut. Tempat penelitian yang dibahas yakni Al-Hasyimiyah Boutique Store yang merupakan Usaha Mikro Kecil Menengah yang berada dibawah Pondok Pesantren Nurul Jadid. Rumusan masalah adalah mengapa pekerja menyetujui Perjanjian Kerja Waktu Tidak Tertentu (PKWTT) dan bagaimana implementasi hukum Undang-Undang Nomor 13 Tahun 2003 tentang ketenagakerjaan. Metode penelitian yang dipakai dalam penelitian ini yakni Metode Kualitatif Deskriptif. Dengan melakukan cara wawancara dan observasi secara langsung kepada pegawai Al-Hasyimiyah Boutique Store. Hasil dari penelitian ini yakni Bahwasannya para anggota Al-Hasyimiyah Boutique Store memahami tentang pentingnya perjanjian tertulis dalam hubungan kerja. Namun dari hasil penelitian bahwa Usaha Mikro Kecil Menengah yang berada dilingkup pesantren ini tidak mematuhi tata cara dan prosedur pemutusan hubungan kerja yang terdapat dalam Undang-Undang Nomor 13 tahun 2003 tentang ketenagakerjaan yang tidak dipatuhi. Dari pihak karyawan tidak ada tuntutan hak atas PHK yang dilakukan oleh pihak Usaha Mikro Kecil Menengah sesuai dengan Undang-Undang Nomor 13 Tahun 2003. Hal ini dikarenakan mereka telah mengetahui dan memahami bahwa mereka bekerja untuk pesantren dan hal tersebut merupakan bentuk kepatuhan terhadap pesantren.</p>
On the Other Shore: Water in Latine Illness Narratives
Authors: Veloria Elyse 
Published: November 2023

Abstract
Drawing on Afro-Caribbean and Black theories, this paper analyzes water as metaphor in Isabel Allende’s “Paula” and Gabriel García Márquez’s Love in the Time of Cholera. I read these texts as illness narratives to conceptualize water as a generative space where the authors negotiate death, grief, and loss. Although these texts are written by established, canonical Latin American writers, this paper attends to the overlapping iterations of water as currents, clouds, and rivers throughout the texts, emphasizing water’s potential to be a mode and method of transformation and memory. Water, as Márquez describes, can carry illness and even the threat of death. Yet water is also a necessary life-sustaining force and animates the relationships and connections that tie bodies together. Therefore, I consider bodies of water and water in bodies, exploring the linkages between mother and daughter through birth and the ways people visualize reflections of their past lives and selves. Charting water as a recurring symbol throughout the texts captures the ebbs and flows of emotion across the texts, and illustrates the blurred, rippling boundaries reverberating between grief, love, and loss.

KEYWORDS: Illness Narratives, Water, Transformation, Isabel Allende, Gabriel García Márquez
Resumen:
Basándose en teorías afrocaribeñas y negras, este artículo analiza el agua como una metáfora en los libros Paula de Isabel Allende y Amor en tiempos de cólera de Gabriel García Márquez. Yo interpreto estos libros como narrativas enfermizas para conceptualizar el agua como un espacio generativo donde los autores negocian la muerte, el dolor, y la pérdida. Aunque estos libros están escritos por autores latinoamericanos consagrados y canónicos, noto en las novelas muchas reiteraciones del agua tales como corrientes, nubes, y ríos para ilustrar el agua como una forma y método de transformación y memoria. El agua, como describe Márquez, puede acarrear enfermedades e incluso amenazar de muerte. Pero además, el agua es una fuerza necesaria para sustentar la vida y animar las relaciones y conexiones que unen a los cuerpos. Por lo tanto, considero los cuerpos de agua y el agua en los cuerpos, como una exploración del vínculo entre la madre e hija a través del nacimiento y las maneras que las personas visualizan las reflexiones sobre sus vidas y sobre sí mismas. Trazar el agua como un símbolo recurrente a través de los textos captura los flujos y reflujos de emociones en los libros e ilustra los límites borrosos y fluctuantes que reverberan entre el dolor, el amor y la pérdida.
Palabras claves: Narrativas enfermizas, agua, transformación, Isabel Allende, Gabriel García Márquez.
Macho Mama
Authors: Ross Laguna Jen 
Published: November 2023

Jen Ross Laguna's nonfiction has appeared in Guernica Magazine and Hispanic Magazine. Her poetry appears in Better than Starbucks, Last Stanza Poetry Journal, the other side of hope, Descant and in an anthology by The Poet Magazine. Her fiction has appeared in The Pine Cone Review, The Global Youth Review, Isele Magazine, Evocations Review, the Arlington Literary Journal, and the Everlast anthology by Dragon Soul Press.
La vida es pornografía igualitaria. <em>Inmaculada o los placeres de la inocencia</em> de Juan García Ponce
Authors: Avila Ponce de León Eric Miguel 
Published: November 2023

Resumen
La obra del escritor mexicano Juan García Ponce es considerada uno de los ejemplos más importantes de literatura erótica en lengua española. Sin embargo, ninguna causó tanta polémica como su novela de 1989 debido a su su carácter fehacientemente pornográfico. Existen críticos que defienden Inmaculada argumentando que en realidad no es pornográfica, sino intensamente erótica, y por tanto, se trata de una obra más de gran calidad artística del autor yucateco. Sin embargo, en este artículo, hago uso de algunas ideas de teoría feminista para cuestionar la validez crítica de lo “erótico”, como medida para determinar lo artístico. Esto con el fin de traer a colación lo que algunos investigadores han determinado como la tradición histórica de la pornografía literaria, la cual introduzco como la nueva medida crítica, y filológica, para estudiar Inmaculada o los placeres de la inocencia. Dado que las novelas Justine y Juliette del Marqués de Sade son los modelos de pornografía literaria que García Ponce siguió para la escritura de Inmaculada, en este artículo realizo un análisis comparativo entre las tres obras para establecer las diferencias claves entre ambas, y las contribuciones del escritor yucateco a la tradición histórica de la pornografía literaria. Finalmente, debido al hecho de que la protagonista de Inmaculada es mujer, cotejo sus experiencias en la novela con teoría feminista sobre la sexualidad femenina, así como con ideas generales de teóricas y pornógrafas feministas que buscan modelos “igualitarios” de producción sexual.
PALABRAS CLAVE: Juan García Ponce; Sade; literatura mexicana; pornografía; feminismo.
Abstract
The work of the Mexican writer Juan García Ponce is considered one of the most important examples of erotic literature in the Spanish language. However, none caused as much controversy as his 1989 novel, Inmaculada o los placeres de la inocencia, due to its patent pornographic nature. There are critics who defend Inmaculada, arguing that it is not really pornographic, but rather intensely erotic, and therefore, it is another work of great artistic quality by the Yucatecan author. However, in this article, I use of some ideas from feminist theory to question the critical validity of the “erotic” as a measure to determine the artistic. This in order to bring up what some researchers have determined as the historical tradition of literary pornography, which I introduce as the new critical and philological measure to study Inmaculada o los placeres de la inocencia. Given that the novels Justine and Juliette by the Marquis de Sade are the models of literary pornography that García Ponce followed for the writing of Inmaculada, in this article I carry out a comparative analysis between the three works to establish the key differences between them, and the contributions of the Yucatecan writer to the historical tradition of literary pornography.
Keywords: Juan García Ponce; Sade; Mexican literature; pornography; feminism.