bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation and Implementation of 3-Dimensional Scientific Literacy Test (Lisa3D Test): Measuring Scientific Literacy for Senior High School Students based on Scientific Reasoning, Scientific Inquiry, and Nature of Science
Authors: Susongko Purwo , Abdul Wahab Norwaliza Binti , Arfiani Yuni , Kusuma Mobinta 
Published: January 2025

This research aims to validate and implement an instrument to measure the scientific literacy of high school science program students, including the abilities of Scientific Reasoning, Scientific Inquiry, and Nature of Science (NOS), called the Lisa3D Test. These three instruments were validated using the Rasch model approach and presented as a digital application. This research method was a descriptive survey with a quantitative approach. The research started from the test design, validation, and implementation stages. The types of validity used included content, psychometric, construct, and external validity. For construct validity, the instrument was tested on 197 high school students, while the implementation stage involved 407 students. The research results show that the Lisa3D Test has fulfilled all aspects of validity. The Lisa3D test has been successfully implemented via the page www.lisatest.id with a cut of 56% for the Scientific Reasoning test, 50% for the Scientific Inquiry test, and 56.25% for the NOS test. This research produces a standard instrument to measure the scientific literacy of high school science program students based on three dimensions, namely Scientific Reasoning, Scientific Inquiry, and Nature of Science (NOS). The Lisa3D test can be implemented on a broader scale and can be an additional criterion for graduating high school students so that all graduates can master science comprehensively.
Reconstruction of Ethno-STEM Integrated Project Learning Models for Explanation of Scientific Knowledge Regarding Aroma Compounds of Indonesian and World Herbal Teas
Authors: Sudarmin Sudarmin , Savitri Erna Noor , Pujiastuti Rr. S. E. , Yamtinah Sri , Mohd Zaim H. Hanim binti , Ariyatun  
Published: January 2025

The background to this research is the importance of finding an integration pattern between the project learning model and Ethno-STEM based inquiry to explain scientific knowledge regarding the aroma of herbal tea. The fundamental research objective is to design an integration pattern for the project and Ethno-STEM learning model and reconstruct scientific knowledge based on public knowledge of the aromatic volatile compounds of Indonesian and world herbal teas. This research method and approach is mixed research. This qualitative approach is to find the integration of the project learning model and Ethno-STEM (Ethno-STEM PjLM) and its syntax. A quantitative approach regarding analyzing tea aroma volatile compounds using an Arduino gas sensor: research data from literature studies, interviews, reconstruction, and data on identifying volatile compounds in the aroma of herbal tea analyzed descriptively, qualitatively, and quantitatively. The results of the research concluded: (1) the reconstruction and integration pattern between PjLM Ethno-STEM is an integrated pattern with SUDARMIN syntax, (2) the reconstruction of scientific knowledge based on public knowledge regarding the process of isolation, extraction, and bioactivity of secondary metabolites, (3) herbal tea aroma volatiles compounds are identified by Arduino sensor: carbon dioxide, methane, propane, butane, acetone, alcohol, and ester, (4) the implementation of Ethno-STEM PjLM received a positive response from students.
ПОСТПИРОГЕННЫЕ ИЗМЕНЕНИЯ КОМПЛЕКСА СЕТЧАТОКРЫЛЫХ (NEUROPTERA) В ЛЕСАХ МОРДОВСКОГО ЗАПОВЕДНИКА
Authors: МАКАРКИН В.Н. , РУЧИН А.Б. 
Published: January 2025

Комплексы сетчатокрылых изучались в 2022-2023 гг. с помощью приманочных ловушек на местах пожаров 2021 г., через 12-13 лет после пожара 2010 г. и на не подвергавшихся пожарам участках в Мордовском заповеднике. Оказалось, что сильные пожары, при которых уничтожается вся или почти вся растительность, по-разному влияют на разные экологические группы сетчатокрылых. Они благоприятны для хортобионтых златоглазок (например, Chrysopa abbreviata, Ch. walkeri, Ch. commata) и опушечных видов (например, Apertochrysa prasisaи A. ventralis), в результате чего их численность возрастает. Но такие пожары очень неблагоприятны для дендробионтов, особенно таких видов, как Nineta alpicola, N. vittata и Chrysotropia ciliata, которые могут исчезать в местах пожаров или очень долго не могут восстановить свою численность.
We examined neuropteran assemblages of the Mordovia Nature Reserve collected in 2022 and 2023 using bait traps at the site of 2021 and 2010 fires and in areas not exposed to these fires. We found that the fires, in which almost all vegetation was destroyed, had different effects on different ecological groups of Neuroptera. Fires were favorable for chortobiont (herb-dwelling) species (e. g., Chrysopa abbreviata, Ch. walkeri, Ch. commata) and species preferring forest edges (e. g., Apertochrysa prasisa and A. ventralis) which increased their numbers. Such fires were, however, very unfavorable for dendrobiont (tree-dwelling) species, especially e. g., Nineta alpicola, N. vittata and Chrysotropia ciliata, which disappeared from burned areas or were unable to restore their numbers in this time.
ИЗУЧЕНИЕ ЛЕСОВОССТАНОВИТЕЛЬНЫХ СУКЦЕССИЙ НА РАЗНЫХ СТРУКТУРНЫХ УРОВНЯХ (НА ПРИМЕРЕ ПОСЛЕПОЖАРНЫХ СУКЦЕССИЙ В ЛЕСАХ СИХОТЭ-АЛИНЯ)
Authors: КОМАРОВА Т.А. 
Published: January 2025

На основе известных положений системного подхода рассматриваются некоторые узловые вопросы сукцессионных преобразований на биогеоценотическом (экосистемном), фитоценотическом, микроценотическом и популяционном структурных уровнях на примере послепожарных сукцессий в широколиственно-кедровых и темнохвойно-кедровых лесах Сихотэ-Алиня. В исследованиях на биогеоценотическом уровне использованы индикационные методы, основанные на анализе градиентов ведущих факторов среды по блокам индикаторных видов и региональным экологическим шкалам. Основное внимание на фитоценотическом уровне изучения сукцессий уделено вопросам видового и ценотипического состава сообществ. На микроценотическом уровне рассматривали вопросы преобразования основных элементов мозаики фитоценозов (синузий и микроценозов) и их эквивалента в биогеоценозах (парцелл). На популяционном уровне устанавливали онтогенетические состояния растений разных видов и возрастную структуру ценопопуляций, рассмотрена динамика всхожих семян, находящихся в латентном онтогенетическом состоянии в подстилке и почве.
Based on the well-known provisions of the general theory of systems, some key issues of successional transformations at the biogeocenotic (ecosystem), phytocenotic, microcenotic and population structural levels are considered on the example of post-fire successions in broad-leaved Korean Pine and dark coniferous Korean Pine forests of Sikhote-Alin. In research at the biogeocenotic level, long-term regime observations of individual environmental factors were used, as well as indicative methods based on the analysis of gradients of leading environmental factors by groups of indicator species, blocks of diagnostic species according to the Brown-Blanke ecological and floristic approach and regional ecological scales. The main attention at the phytocenotic level of the study of successions was paid to the issues of spatial structure, species and cenotypic composition of communities, dynamics of the number and productivity of communities. At the microcenotic level, the issues of transformation of the main elements of the mosaic of phytocenoses (synusions and microcenoses) and their equivalents in biogeocenoses (parcels) are considered. Ontogenetic states and the age structure of cenopopulations were established at the population level.
Apreciación de residuos orgánicos agrícolas como sustrato para el cultivo del hongo comestible Pleurotus pulmonarius
Authors: Caicedo Ruiz William , Cuadrado Cano Bernarda , Infante Jiménez Cherlys 
Published: January 2025

El mercado de hongos comestibles es muy grande, siendo una alternativa alimenticia para reemplazar la carne, sumado a sus propiedades nutracéuticas y con la posibilidad de cultivarlos aprovechando desechos orgánicos de origen agrícola. Se recolectaron y prepararon semillas de almendra (Terminalia catappa) y cáscaras de achiote (Biza orellana), cacahuate (Arachis hypogaea) y arroz (Oriza sativa) e inocularon con micelio de Pleurotus pulmonarius. Se evaluaron los tiempos de crecimiento del hongo, la eficiencia biológica y relación entre minerales del sustrato y producto. En achiote y maní hubo mayor acumulación de proteína (12,4%±1,6 y 10,9%±0,6 respectivamente). La cáscara de maní fue el único sustrato donde fructificó el P. pulmonarius con relación entre la concentración de nitrógeno vs. diámetro del sombrero, del pie y longitud del pie (p<0,05) y eficiencia biológica de 8,47% en la primera cosecha, perfilándose como un residuo agrícola orgánico con alto potencial para el cultivo de este hongo.
El mercado de hongos comestibles es muy grande, siendo una alternativa alimenticia para reemplazar la carne, sumado a sus propiedades nutracéuticas y con la posibilidad de cultivarlos aprovechando desechos orgánicos de origen agrícola. Se recolectaron y prepararon semillas de almendra (Terminalia catappa) y cáscaras de achiote (Biza orellana), cacahuate (Arachis hypogaea) y arroz (Oriza sativa) e inocularon con micelio de Pleurotus pulmonarius. Se evaluaron los tiempos de crecimiento del hongo, la eficiencia biológica y relación entre minerales del sustrato y producto. En achiote y maní hubo mayor acumulación de proteína (12,4%±1,6 y 10,9%±0,6 respectivamente). La cáscara de maní fue el único sustrato donde fructificó el P. pulmonarius con relación entre la concentración de nitrógeno vs. diámetro del sombrero, del pie y longitud del pie (p<0,05) y eficiencia biológica de 8,47% en la primera cosecha, perfilándose como un residuo agrícola orgánico con alto potencial para el cultivo de este hongo.
«И Виргилия нет за плечами, – только есть одиночество»: образ Парижа и парижские мотивы в литературном наследии Владислава Ходасевича
Authors: Guseva Natalia 
Published: January 2025

Литературное наследие представителей первой волны русской эмиграции навсегда запечатлело об-раз французской столицы глазами русского вынужденного эмигранта – образ прекрасного, почти сказочного города, в котором многие из них побывали еще детьми, позднее ставшего свидетелем их метаморфоз. Для множества литераторов первой волны Париж стал второй европейской столицей, принявшей их. Первой для многих оказался Берлин, который в первые послереволюционные годы был почти обязательным транзитным пунктом для русского интеллигента, покинувшего советскую Россию, «чем-то вроде узловой станции», по меткому выражению Леонида Андреева.Одной из ключевых фигур литературного небосклона Парижа тридцатых годов, бесспорно, явля-ется Владислав Ходасевич — умный, тонкий, проницательный критик. Набоков считал его крупней-шим поэтом своего времени, «литературным потомком Пушкина»; Гумилев назвал его «европейцем по любви к деталям красоты». Однако Париж оказался для Ходасевича местом бытовой неустроен-ности, духовного одиночества и невозможности творить свободно.В европейской картине мира Париж наделен богатыми коннотациями — это город любви, вдох-новения, искусства и т. д. Тем интереснее становится фиксация парижских смыслов в опыте людей разных эпох, национальностей, происхождения. Для этой фиксации мы применим лингвистиче-ский и дискурсивный подходы, в центре которых находятся способы категоризации и языковой ре-презентации пространства, при этом важно будет помнить, что пространственные описания любых типов коррелируют с символическими ценностями и с эстетикой автора или авторов.Сочетание двух подходов – сопоставительного, призванного оттенить парижскую атмосферу эмигрантского бытия на фоне двух российских столиц, Петербурга и Москвы, а также Берлина, и микроисторического (Дж. Леви, К. Гинзбург), предполагающего максимально детализированное из-учение фактов жизни конкретного человека, его индивидуальных стремлений и действий в сопря-жении с макроисторическим контекстом, позволяет раскрыть образ Парижа и парижские мотивы в литературном наследии Ходасевича в более полном объеме, что, в свою очередь, вносит вклад в изучение творчества поэта, критика и публициста.Собрание стихов 1927 года (сумма его сильнейшей поэзии) и Некрополь 1939 года — две главные книги Ходасевича, и обе составлены и изданы в Париже. Они представляют собой его «патент на благородство» и оправдание творческой жизни. В его творчестве материальность Парижа как го-родского пространства стала метафорической — это колодец парижского двора, из которого уже нет пути в большой открытый мир, и дискурсивной — это некрополь, умозрительное кладбище культурной эпохи.
Karakteristik hidrolisat kolagen kulit ikan tenggiri kering dengan enzim papain
Authors: Rahmawati Hafni , Agustini Tri Winarni , Dewi Eko Nurcahya , Trianto Agus 
Published: January 2025

Pemanfaatan kulit ikan tenggiri kering saat ini terbatas pada produk keripik, kerupuk dan empek-empek. Perlu usaha pengolahan menjadi produk yang kaya manfaat, yaitu hidrolisat kolagen untuk peningkatan nilai guna. Enzim papain digunakan pada proses hidrolisis kolagen karena lebih efektif dan menghasilkan rendemen yang lebih banyak dibandingkan enzim lainnya. Tujuan penelitian untuk menentukan persentase enzim papain dan lama perendaman optimum pada proses hidrolisis kolagen kulit ikan tenggiri kering berdasarkan karakteristik kolagen kulit ikan tenggiri kering. Rancangan penelitian menggunakan rancangan acak lengkap faktorial (RALF) dengan dua faktor, yaitu perbedaan persentase enzim papain (1 dan 2%) dan lama waktu perendaman (12 dan 24 jam). Interaksi kedua faktor tersebut berpengaruh pada derajat hidrolisis, derajat putih, kadar protein, viskositas, kekuatan gel, titik leleh, kelarutan dan kemampuan membentuk busa namun tidak memengaruhi redemen, kadar air, abu, lemak, pH dan zeta potensial hidrolisat kolagen. Hasil menunjukkan kondisi optimum hidrolisis kolagen kulit ikan tenggiri kering, yaitu menggunakan enzim papain 2% dan lama perendaman 24 jam dengan rendemen 2,30%, derajat hidrolisis 35,62%, derajat putih 77,73%, kadar air 6,94%, abu 1,44%, protein 95,35%, lemak 2,33%, viskositas 6,13cp, kekuatan gel 46,64 gBloom, titik leleh 14,67OC, pH 5,83, zeta potensial 2,47mV, kelarutan 82,00% dan pembentukan busa 31,67%. Hidrolisat kolagen kulit kering ikan tenggiri mendukung pengembangan produk samping perikanan bernilai tinggi dan mendorong pembangunan ekonomi berkelanjutan.
Exploring the Role of FDG PET CT Scan in Detecting High Grade Diffuse Large B-Cell Lymphoma
Authors: Azmoun Marzieh , Nodeh Mohammad Moeini , Emadzadeh Maryam , Ariana Kamran , Dadgar Habibollah , Khorosanchi Amirreza , Askari Emran , Nazar Eisa 
Published: January 2025

Introduction. Diffuse B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma. Currently, the standard method for evaluating patients at the initial stages of cancer diagnosis in Mashhad oncology centers involves computed tomography scans (CT scans), histopathological evaluation of tissue, bone marrow sampling, and cytogenetic studies, all of which are time-consuming and costly. It is worth mentioning that at present, the most recommended approach for determining lymphoma staging is the FDG-PET/CT scan, which combines labeled glucose with CT scan and offers a more accurate alternative. The objective of this study is to explore the potential of FDG-PET/CT scan as a tool for detecting high-grade lymphoma.Methods. In this study, patients with different types of DLBCL who underwent FDG-PET Scan for staging at Razavi Hospital, Mashhad, Iran between 2017 and 2021 were examined. The necessary clinical and paraclinical information, including the stage of the disease, the involved site at the time of diagnosis, the result of immunohistochemical examination, and the response to treatment were collected. FDG-PET Scan information including the extent of involvement and metabolic activity of the tumor before the start of treatment, pathological characteristics of the tumor, clinical behavior, and response to treatment in the form of response rate (RR), disease-free survival (DFS) and overall survival (OS) of the patients. Was also investigated. Aggressive histology in the present study was classified based on morphological characteristics and immunohistochemical staining, prognostic indicators, clinical behavior and response to treatment. Data were analyzed using SPSS software at a significance level of p<0.05.Results. Comparing the two groups of patients with high grade histology (n=12) and NOS (n=14), the results showed that SUV max values in patients with aggressive lymphoma were 27.5 ± 15.6 (median 25.6) and in patients with NOS lymphoma was 15.4 ± 9.8 (median 14.4) (p=0.01). The overall survival of patients in the aggressive group was 10 months and in the non-aggressive group was 24 months (p=0.002). Also, the cut — off -point of 21.1 for SUV max has a sensitivity of 66 % and a specificity of 72 % in differentiating aggressive from non-aggressive types.Conclusion. The results revealed that FDG PET CT Scan can provide valuable insights into differentiating lymphomas with a more aggressive type from their usual types, as those with heightened metabolic activity (SUVmax) are often indicative of aggressive behaviors.
Urban waterlogging simulation of derived short-duration double-peak rainstorm pattern
Authors: Zhang Jinping , Kong Lingli , Li Xuechun 
Published: January 2025

ABSTRACT

It is actually difficult to quantify the characteristics of short-duration double-peak rainstorm (SDDPR), so the current study on the urban waterlogging simulation of its rainstorm pattern is rare. In this study, a new derivation methodology of SDDPR considering rainfall statistics correlations is proposed. With the non-source inundation method with the geographic information system (GIS)-based storm water management model (SWMM), urban waterlogging is simulated to present the hydrological and hydrodynamic characteristics. The results show that the proposed new derivation methodology of SDDPR reflects the actual rainstorm well, and the simulated urban waterlogging situation of the derived rainstorm confirms the different characteristics of surface ponding at junctions, flow in conduits, and outflows in outlets: with the increase of conditional probability and recurrence period (RP), the situation with average ponding hour-duration and earlier ponding time has increased, which represents more retention water can be produced quickly. With the change of RP from 1 to 10 years, the rate of overloaded conduit numbers with its full-flow time being beyond 0.5 h to total conduit numbers has added from 48 to 78%, waterlogging area of the study area has increased from 105,400 to 2,080,000 m2, ponding depth attains to 50 cm gradually, and the southeast in the study area is prone to be waterlogged.
Advanced Pain Management in Patients with Terminal Cancer
Authors: Khojayeva Kamilla , Aubakirova Mina , Viderman Dmitriy 
Published: January 2025

Abstract:
Understanding and managing pain in patients with terminal cancer is a vital
aspect of palliative care, aimed at relieving suffering and improving quality of life in the
final stages of illness. Studies indicate that approximately 50% of patients with stage 4
cancer report moderate to severe pain, with a quarter experiencing severe cancer-related
pain. Despite opioid prescriptions in 97% of cases, a significant portion of patients continues
to suffer unresolved pain during the last week of life. Cancer-related pain is multifaceted,
often involving nociceptive, neuropathic, and mixed elements, necessitating a
thorough, multidimensional approach to both assessment and treatment. The challenge
of opioid tolerance and the potential for addiction demands careful monitoring. Interventional
therapies, including nerve blocks and spinal cord stimulation, are gaining attention
as valuable complements or alternatives to opioid use. Additionally, alternative
methods like yoga, special diets, and food supplements provide diverse options for managing
pain. Psychological therapies, including cognitive-behavioral techniques and mindfulness,
address the mental and emotional dimensions of pain. Emerging technologies,
including artificial intelligence, hold promise for optimizing pain management in terminal
cancer care. This review explores advanced pain management strategies, focusing on
traditional opioid therapies, modern pharmaceutical innovations, and non-pharmacological
approaches such as alternative medicine, massage, dietary interventions, and psychological
therapy.
Untargeted Metabolomics and Bioactivities Assessment of Xylaria ellisii, an Endophytic Fungus Isolated from the Leaf of the Plant Acorus calamus Linn.
Authors: Prajapati Chandrabhan , Rai Sachchida Nand , Singh Anurag Kumar , Rajak Naina , Garg Neha , Singh Santosh Kumar 
Published: January 2025

Introduction:
Fungal endophytes have mutualistic associations with the plant's host, communicating
through genetic and metabolic processes. As a result, they gain the ability to generate therapeutically
effective metabolites and their derivatives.

Methods:
The current study aims to assess antioxidant potential along with the identification of robust metabolites
within the crude extract of a potent endophytic fungus Xylaria ellisii isolated from leaf tissues of the
Acorus calamus Linn plant.Four endophytic fungi were obtained from leaf tissues of Acorus calamus Linn.,
and identified morphologically and molecularly as distinct species. Each ethyl acetate extract of the isolated
fungi exhibited a unique chemical profile in the HPTLC fingerprint at various wavelengths. The ethyl acetate
(EA) extract from the fungal strain ACL-4 (Xylaria ellisii) demonstrated the strongest antioxidant activity
among the four fungal endophytes examined, with an EC50 value of 292.64 ± 3.558 μg/mL. Remarkably, fungal
endophyte ACL-4 extract exhibited superior antimicrobial activity at the less concentrations compared to
ACL-ME extract of leaf crude.

Results:
The extract of ACL-ME-treated HEK 293T cells exhibited significant toxicity, with an IC50 value of
1481.74 ± 23.772 μg/mL, compared to fungal strain ACL-4-treated HEK 293T cells, which had an IC50 value
greater than 2000 μg/mL. Consequently, the crude extract of ACL-4 and ACL-ME along with the standard
drug methotrexate exhibited cytotoxic activity against cancer cell line MDA-MB-231 with IC50 concentrations
of 146.65 ± 0.394 μg/mL, 528.46 ± 10.912 μg/mL, and 134.11 ± 3.446 μg/mL, respectively. A total of 2,255
compounds were detected through LC-HRMS-based metabolomics in the crude metabolites of Xylaria ellisii,
with certain compounds identified in multiple instances. Among this repertoire, 62 robust bioactive compounds
were identified through meticulous screening, guided by existing literature. Comparative HPTLC fingerprint
analysis, along with antioxidant efficacy assays of ethyl acetate extracts of Xylaria ellisii derived
from Acorus calamus leaves and Cassia fistula twigs revealed the host-specific production of bioactive chemicals.

Conclusion:
The top-scoring Keap1 inhibitors derived from Xylaria ellisii, including Pregabalin (-6.083
Kcal/mol), Ferulic acid (-5.434 Kcal/mol), (R)-Piperidine-2-carboxylic acid (-5.31 Kcal/mol), Genipin (-5.197
Kcal/mol), and Brivaracetam (-5.17 Kcal/mol), respectively were considered as Keap 1 inhibitors, potentially
mitigate oxidative stress.