bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Smartphone Notifications Help With Gout Management? A Feasibility Study
Authors: Emad Yasaman , Dalbeth Nicola , Weinman John , Chalder Trudie , Petrie Keith J. 
Published: November 2023

ObjectiveThis feasibility study aimed to assess the acceptability of using smartphone notifications to modify the medication beliefs of people with gout. We evaluated the feasibility and acceptability of a smartphone application using the Technology Acceptance Model. We explored adherence rate differences and outcomes between the intervention and control groups.MethodsFifty-two patients with gout who were prescribed allopurinol were randomly assigned to either active control (n = 24) or intervention group (n = 28). Over 3 months, both groups used the study app on their smartphones. The active control group received notifications about general health advice, whereas the intervention group received adherence-targeted notifications. The feasibility and acceptability of the smartphone app was measured through semistructured interviews. Adherence rate was assessed through serum urate levels and missed doses at 3 timepoints: baseline, 3 months (post intervention), and 6 months (follow-up).ResultsThe smartphone app demonstrated high feasibility, with strong participant retention and compliance. The participants expressed high levels of satisfaction with the app’s user-friendliness and content, highlighting its acceptability. Both groups showed a significant reduction in missed doses over time (P< 0.05), but no significant differences in serum urate levels were found between the groups. Patients who received adherence-targeted notifications reported finding it more convenient to take allopurinol and expressed higher overall treatment satisfaction throughout the study.ConclusionAdherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in patients with gout. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.
Sur quelques mythes et fantômes de la science espagnole
Authors: Pimentel Juan , Mandressi Rafael 
Published: November 2023

L’histoire des sciences espagnoles est remplie de morts-vivants : des présences intermittentes et fugaces, des cadavres sans sépulture ou méconnus. Ce sont les spectres ou les fantômes des sciences espagnoles. Dans cette contribution, nous nous concentrons sur le musée du Prado, un espace habité par ces fantômes, puisque les musées, après tout, sont des lieux de mémoire autant que d’oubli. Nous accorderons une attention particulière à deux portraits mélancoliques : celui de Jovellanos par Goya et l’autoportrait de Ramón y Cajal, le grand histologiste du tissu nerveux.
Contre le piège de l’évidence. La controverse des neiges du Kilimandjaro (1848-1862)
Authors: Froment Delphine 
Published: November 2023

En 1848, le missionnaire Johannes Rebmann devient le premier Européen à observer et décrire le Kilimandjaro, en Afrique de l’Est. Dans son récit de voyage, il affirme que le sommet de la montagne est recouvert de « neiges éternelles ». En Europe, dans les sociétés de géographie, de nombreux savants restent dubitatifs devant un tel phénomène. S’ensuit une importante controverse géographique, qui dure plus d’une décennie. Cet article revient sur les différents ressorts de cette dispute savante, longtemps occultée dans l’historiographie, pour analyser au plus près les logiques savantes et socioprofessionnelles qui président à la négociation de l’autorité scientifique sur la scène géographique européenne du xix e siècle.
Science pour tous ou science par tous ? Mythes et contre-mythes de la science au xix e siècle
Authors: Fages Volny 
Published: November 2023

Le second xix e siècle est un moment crucial dans la construction, en France, de l’image de la science la présentant comme difficile d’accès et réservée à une élite savante de plus en plus professionnalisée. Progressivement s’impose le mythe d’une séparation nette, dans la production de connaissances, entre des praticiens experts d’un côté et un public curieux mais passif de l’autre. Les vulgarisateurs français contribuent activement à affirmer cette séparation, en défendant l’idée d’une science pour tous plutôt que celle d’une science par tous. Ce mythe rencontre néanmoins de multiples résistances, des mythes concurrents émergent, en particulier celui d’une science démocratique, ouverte et accessible à tous, et dans la pratique, de multiples contre-cultures savantes se développent dans les interstices des représentations dominantes de la science.
Retour sur dix ans d’expérimentation artistique : La Bulle Bleue de Montpellier
Authors: Maurel Delphine 
Published: November 2023

L’auteure revient sur la création de La Bulle Bleue, lieu de Fabrique artistique et culturelle à Montpellier (France), animé par des comédiens et comédiennes, des techniciens et techniciennes du spectacle vivant, des paysagistes et des cuisiniers et cuisinières en situation de handicap. L’auteure, directrice de l’établissement organisé en ESAT, revient sur la manière dont au fil des années s’est élaboré le projet et la manière dont il suscite parmi les équipes de nombreux questionnements, en particulier sur la notion du travail et, par ricochet, la professionnalisation. Questionnement multiple, amplifié par la spécificité artistique du projet et la dimension du handicap. Quel est le travail de professionnels en situation de handicap en ESAT ? Quelle est la reconnaissance professionnelle des personnes qui n’ont pas un statut de salarié ? Un comédien non intermittent du spectacle peut-il être considéré comme professionnel ? Qu’est-ce qu’être professionnel pour un artiste ? Les acteurs permanents d’une troupe structurée en ESAT artistique peuvent-ils être considérés comme professionnels ? L’auteure propose une réflexion sur les dimensions de travail et d’inclusion enrichie d’une perspective européenne sur ces questions.
La publicisation du handicap
Authors: Blanc Alain 
Published: November 2023

Comment est-on parvenu au fil du vingtième siècle à constituer un « capital de visibilité » (Heinich 2012) pour les personnes handicapées et faire du handicap un objet public digne d’interventions et d’actions publiques ? Pour répondre à cette question, l’article expose, dans un premier temps, la manière dont s’élabore progressivement la publicisation du handicap. L’auteur revient ensuite sur les trois temps qui ont contribué à cette publicisation : les prises de parole par les personnes handicapées, les canaux de diffusion et le contexte favorable à leur réception. Le concept de « valeur d’exposition », emprunté à Walter Benjamin, en rapprochant les notions de marchandisation et de spectacularisation, permet d’expliciter dans un dernier temps les conditions sociales favorisant la croissance du capital de visibilité des personnes handicapées.
Professionnalisation des artistes en situation de handicap dans le champ du spectacle vivant : quelques réflexions à la suite de rencontres de compagnies européennes
Authors: Fraisse Jacques 
Published: November 2023

De 2021 à 2023, la compagnie de théâtre La Bulle Bleue de Montpellier porte le projet européen de mobilités PERFORMHAND (Erasmus +). L’objectif de ces mobilités, effectuées auprès de cinq structures en Allemagne, en Belgique, en Espagne et aux Pays-Bas, est de saisir les différentes modalités de mise en œuvre de la professionnalisation des personnes en situation de handicap dans les métiers du spectacle vivant. Quels enseignements peut-on retirer de la comparaison à l’issue de ces cinq rencontres ? Comment la professionnalisation des artistes en situation de handicap se réalise-t-elle selon les pays ? Comment les processus d’inclusion sont-ils mis en œuvre ? Voici quelques-unes des questions traitées dans cet article.
Un contrat de coopération commerciale ne peut être régi par les Principes Unidroit choisis par les parties
Authors: Bureau Dominique , Muir Watt Horatia 
Published: November 2023

Il résulte de l’article 3, paragraphe 1, de la Convention de Rome du 19 juin 1980 sur la loi applicable aux obligations contractuelles, que les principes généraux applicables aux contrats internationaux, tels que ceux qui ont été élaborés par l’Institut international pour l’unification du droit privé (Unidroit), ne constituent pas une loi pouvant être choisie par les parties au sens de cette disposition. S’agissant de contrats de coopération commerciale distincts des contrats « fournisseur », il résulte notamment de leur objet, qui porte sur la promotion commerciale, par le biais de publicités ou de catalogues mis à la disposition des clients ou sur internet, et la visibilité des produits en magasin, qu’ils avaient les liens les plus étroits avec la France. Dès lors que la prestation caractéristique devait être fournie par le distributeur, ayant son siège en France, et que le contrat ne présentait pas de liens plus étroits avec un pays autre, le droit français s’applique aux contrats de coopération commerciale litigieux.
L’urbanisme rural sous contrainte de croissance. Les périphéries rurales de Genève et Luxembourg sur le territoire français
Authors: Idt Joël , Le Bivic Camille , Pauchon Antoine 
Published: November 2023

De nombreux espaces ruraux sont travaillés par des phénomènes de croissance de l’urbanisation. Cet article s’intéresse plus spécifiquement aux espaces ruraux soumis à une forte croissance démographique et à une pression foncière du fait de l'influence d'une métropole frontalière. Nous avons choisi d’étudier les espaces ruraux français en périphérie de Genève et Luxembourg. Nous analysons leurs transformations à l’aune de l’action collective et des pratiques des acteurs de l'urbanisme.Nous qualifions les problématiques d’urbanisme auxquelles les acteurs sont confrontés dans ces espaces ruraux, ainsi que les modalités d’intervention en la matière : comment se caractérisent les formes d’action collectives en urbanisme dans les espaces ruraux sous contrainte de croissance d’une métropole frontalière ? Que font les acteurs de l’urbanisme lorsqu’ils cherchent à contrôler la pression de l’urbanisation qui s’exerce sur ces espaces ?Nous montrons que la situation de croissance de l’urbanisation transfrontalière pose des problèmes particuliers de régulation auxquels sont confrontés les acteurs publics, aussi bien locaux qu’étatiques. Les réponses dépendent fortement des contextes. Cependant, nous mettons en évidence quelques spécificités des situations d’urbanisme rural qui se jouent dans ces espaces : la difficulté d’intervenir sur les causes premières, essentiellement économiques et fiscales, des dynamiques de croissance qui pèsent sur le territoire du fait de la frontière ; la situation de fragmentation institutionnelle particulièrement forte à laquelle se trouvent confrontés les acteurs ; la mobilisation et la combinaison d’instruments d’urbanisme génériques et ad-hoc dans l’optique de contrôler la croissance et ses effets non souhaités.
The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells
Authors: Ochoa Trini A , Rossi Amy , Woodle E Steve , Hildeman David , Allman David 
Published: November 2023

Abstract
The proteasome inhibitor bortezomib (BTZ) is proposed to deplete activated B cells and plasma cells. However, a complete picture of the mechanisms underlying BTZ-induced apoptosis in B lineage cells remains to be established. In this study, using a direct in vitro approach, we show that deletion of the tumor suppressor and cell cycle regulator p53 rescues recently activated mouse B cells from BTZ-induced apoptosis. Furthermore, BTZ treatment elevated intracellular p53 levels, and p53 deletion constrained apoptosis, as recently stimulated cells first transitioned from the G1 to S phase of the cell cycle. Moreover, combined inhibition of the p53-associated cell cycle regulators and E3 ligases MDM2 and anaphase-promoting complex/cyclosome induced cell death in postdivision B cells. Our results reveal that efficient cell cycle progression of activated B cells requires proteasome-driven inhibition of p53. Consequently, BTZ-mediated interference of proteostasis unleashes a p53-dependent cell cycle–associated death mechanism in recently activated B cells.
A Cross-sectional Study of Correlation of Neutrophil-to-lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Authors: Jain Pankaj Kumar , Seval Manoj , Labana Rohit , Sarla  
Published: November 2023

Background:
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in significant morbidity and mortality. As COPD progresses, patients develop more frequent and severe exacerbations. Several scores have been tested in AECOPD, but none of them is yet widely accepted or recommended to be used in practice due to a lack of data and evidence.

Aim and Objectives:
(1) To compare neutrophil-to-lymphocyte ratio (NLR) between stable COPD patients and patients with acute exacerbation of COPD and (2) correlation of NLR with severity of acute exacerbation of disease as per clinical, spirometric, and arterial blood gas criteria.

Materials and Methods:
A total of 100 patients, 50 with acute exacerbation of COPD and 50 stable patients attending the casualty and Outpatient Department of Government Medical College and Associated Group of Hospitals, Kota, were included in the study.

Results:
The level of NLR was raised in patients with acute exacerbation of COPD (35.28 ± 34.66) as compared to stable COPD patients (2.23 ± 0.63) (P = 0.0001). Levels of this inflammatory marker (NLR) were also positively correlated with the duration of hospitalization (8.14 ± 5.99 days) (P = 0.0010). High NLR was found to be significantly associated with the need for mechanical ventilation (nine patients) and mortality (nine patients), and significantly associated with low forced expiratory volume 1/forced-vital capacity (0.49 ± 0.07) in cases with acute exacerbation of COPD.

Conclusion:
NLR can be used as a marker of acute exacerbation of COPD, as it was found to be significantly elevated in acute exacerbation patients and found within normal limits in stable patients.
Techniques of staged laparoscopic orchidopexy for high intra-abdominal testes in children: A systematic review and meta-analysis
Authors: Borkar Nitinkumar Bhajandas , Tiwari Charu , Mohanty Debajyoti , Vepakomma Deepti , Nagdeve Nilesh 
Published: November 2023

Background:
Laparoscopic exploration is currently considered the gold standard for managing nonpalpable intraabdominal testes. The problem of short vascular pedicle is addressed in Fowler-Stephen (FS) technique by the division of testicular vessels and in Shehata technique (ST) by traction on testicular vessels. There is a lack of the consensus among pediatric surgeons on the choice of one technique over other. This analysis compares the reported outcomes of staged laparoscopic orchidopexy by ST with the time tested FS technique in managing high intraabdominal undescended testis.

Materials and Methods:
The present systematic review and meta-analysis was conducted as per the preferred reporting items for the systematic review and meta-analyses guidelines. Only randomized controlled trials and comparative studies were included. The primary outcomes compared were the incidence of testicular atrophy, testicular retraction/ascent rate, and operative time of Stage I and Stage II orchidopexy.

Results:
The present analysis was based on three randomized studies with a total of 119 undescended testes in 117 patients satisfying the inclusion criteria. The operative time was less in Stage I FS technique; however, there was no statistically significant difference in operative time of both procedures during the Stage II laparoscopic orchidopexy. Pooled analysis of postintervention testicular atrophy, testicular retraction rate, and duration of postoperative hospitalization showed no difference between both procedures.

Conclusion:
Both FS and STs are comparable in terms of postintervention testicular atrophy, testicular retraction/ascent; however, the mean operative time is significantly less with FS technique in Stage I laparoscopic orchidopexy.
Conditional survival probability of distant-metastatic hepatocellular carcinoma: A population-based study
Authors: Yang Yong-Ping , Guo Cheng-Jun , Gu Zhao-Xuan , Hua Jun-Jie , Zhang Jia-Xuan , Shi Jian 
Published: November 2023

BACKGROUND
The prognosis of many patients with distant metastatic hepatocellular carcinoma (HCC) improved after they survived for several months. Compared with traditional survival analysis, conditional survival (CS) which takes into account changes in survival risk could be used to describe dynamic survival probabilities.
AIM
To evaluate CS of distant metastatic HCC patients.
METHODS
Patients diagnosed with distant metastatic HCC between 2010 and 2015 were extracted from the Surveillance, Epidemiology and End Results database. Univariate and multivariate Cox regression analysis were used to identify risk factors for overall survival (OS), while competing risk model was used to identify risk factors for cancer-specific survival (CSS). Six-month CS was used to calculate the probability of survival for an additional 6 mo at a specific time after initial diagnosis, and standardized difference (d) was used to evaluate the survival differences between subgroups. Nomograms were constructed to predict CS.
RESULTS
Positive -fetoprotein expression, higher T stage (T3 and T4), N1 stage, non-primary site surgery, non-chemotherapy, non-radiotherapy, and lung metastasis were independent risk factors for actual OS and CSS through univariate and multivariate analysis. Actual survival rates decreased over time, while CS rates gradually increased. As for the 6-month CS, the survival difference caused by chemotherapy and radiotherapy gradually disappeared over time, and the survival difference caused by lung metastasis reversed. Moreover, the influence of age and gender on survival gradually appeared. Nomograms were fitted for patients who have lived for 2, 4 and 6 mo to predict 6-month conditional OS and CSS, respectively. The area under the curve (AUC) of nomograms for conditional OS decreased as time passed, and the AUC for conditional CSS gradually increased.
CONCLUSION
CS for distant metastatic HCC patients substantially increased over time. With dynamic risk factors, nomograms constructed at a specific time could predict more accurate survival rates.
Mitomycin C and capecitabine: An additional option as an advanced line therapy in patients with metastatic colorectal cancer
Authors: Mullin Gil , Sternschuss Michal , Landman Yosef , Sulkes Aaron , Brenner Baruch 
Published: November 2023

BACKGROUND
In recent years survival of patients with metastatic colorectal cancer (mCRC), though still limited, has improved significantly; clearly, when the disease becomes refractory to standard regimens, additional treatment options are needed. Studies have shown that mitomycin C (MMC), an antitumor antibiotic, and capecitabine, a precursor of 5-fluorouracil, may act synergistically in combination. The efficacy of MMC/capecitabine has been demonstrated in the first-line setting, but only a few small studies have tested it in the advanced-line setting, with contradictory results.
AIM
To summarize our experience using MMC/capecitabine as an advanced line treatment for mCRC.
METHODS
A retrospective study was conducted at a tertiary medical center including all patients with histologically proven mCRC who were treated with MMC/capecitabine after at least two previous lines of standard chemotherapy in 2006-2020. Data on patient demographics and past medical history, laboratory, pathological, and radiological factors, and treatment and survival were collected from the files. Survival analyses were performed using the Kaplan-Meier method. The association of patient and tumor characteristics with treatment effectiveness and toxicity was evaluated with univariate and multivariate proportional hazard Cox regression analyses. P ≤ 0.05 was considered statistically significant.
RESULTS
The cohort consisted of 119 patients of median age 64 years (range 37-85). Patients received a median of 2 MMC/capecitabine cycles (range 0.5-9.0). Thirty-four patients (28.6%) experienced grade ≥ 3 toxicity, including 2 (1.7%) with grade 4; there was no drug-related mortality. The objective response rate was 0.8%, and the disease control rate, 24.4%. Median progression-free survival (PFS) was 2.1 mo (range 0.2-20.3), and median overall survival, 4.8 mo (range 0.2-27.5). The 6-month overall survival rate was 44%; 8.7% of patients remained progression-free. Factors associated with longer PFS were lower gamma-glutamyl transferase level (P = 0.030) and primary tumor location in the left colon (P = 0.017). Factors associated with longer overall survival were lower gamma-glutamyl transferase level (P = 0.022), left-colon tumor location (P = 0.044), low-to-moderate histological grade (P = 0.012), Eastern Cooperative Oncology Group performance status 0-1 (P = 0.036), and normal bilirubin level (P = 0.047).
CONCLUSION
MMC/capecitabine is an active, available, and relatively safe regimen for use beyond standard lines of therapy in mCRC. Several clinical and laboratory parameters can identify patients more likely to benefit.
Role of routine lymph node dissection alongside resection of intrahepatic cholangiocarcinoma: Systematic review and meta-analysis
Authors: Atif Mo , Borakati Aditya , Mavroeidis Vasileios K 
Published: November 2023

BACKGROUND
The global incidence of intrahepatic cholangiocarcinoma (ICCA) is soaring. Due to often delayed presentation, only a narrow spectrum of the disease is usually surgically resectable. To more accurately stage the disease, reduce recurrence, and improve overall survival, surgical teams are increasingly performing intraoperative lymph node dissection (LND) as well. This procedure has its associated morbidity, while there is no consensus or formal guidelines on its role in this setting. Hence, there is a need to better delineate the evidence for performing LND alongside surgical resection of the ICCA.
AIM
To perform a systematic review and meta-analysis on the role of LND in improving prognostication and survival post-resection of ICCA.
METHODS
We performed a systematic literature search using Pubmed, Medline, Embase, and the Cochrane Library, for all studies involving LND, ICCA, and surgical resection using several keywords, Medical Subject Headings (MeSH) tags, and appropriate synonyms. All clinical studies comparing curative intent resection of ICCA with LND vs resection without LND were included, while single-arm case series, studies with insufficient data, and duplicates were excluded. We included all English-language studies from the different academic databases up till early December 2022. The primary outcome measures were set for overall survival (OS) and disease-free survival (DFS).
RESULTS
This systematic review and meta-analysis included 15 studies that fulfilled the selection criteria comprising 11413 patients with surgically-resectable ICCA, of whom 6424 (56.3%) underwent hepatectomy with LND while the remainder underwent hepatectomy only. In patients who underwent LND, on average, 27.7% of the resected lymph nodes were positive for metastatic disease. Overall, the results showed that performing LND did not significantly improve OS or DFS. However, the effect of LND on OS showed a degree of variability by geographical region, in Eastern and Western countries. As LND is increasingly being performed, further time-based analysis was undertaken to identify time-dependent changes in the role of LND. An increasing adoption of LND was not associated with improved OS. Furthermore, no roles were identified for neoadjuvant/adjuvant chemotherapy or increasing lymph node retrieval in improving OS either.
CONCLUSION
LND might aid in staging, prognosticating, and deciding further management of resected ICCA, but does not improve OS and DFS and is unsuitable for high-risk patients unlikely to benefit from further treatments.