bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einstein–Cartan pseudoscalaron inflation
Authors: Di Marco Alessandro , Orazi Emanuele , Pradisi Gianfranco 
Published: February 2024

AbstractWe study a class of early universe cosmological models based on Einstein–Cartan gravity and including a higher derivative term corresponding to a power of the Holst scalar curvature. The resulting effective action is basically given by General Relativity and an additional neutral pseudoscalar field (the pseudoscalaron), unequivocally related to the corresponding components of the torsion, that necessarily acquire a dynamics. The induced pseudoscalaron potential provides a realistic inflationary phase together with a very rich postinflationary epoch, resulting from the coupling of the pseudoscalaron to ordinary matter.
Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer
Authors: Gorchs Laia , Fernández-Moro Carlos , Asplund Ebba , Oosthoek Marlies , Solders Martin , Ghorbani Poya , Sparrelid Ernesto , Rangelova Elena , Löhr Matthias J. , Kaipe Helen 
Published: February 2024

Abstract

In pancreatic ductal adenocarcinoma, the infiltration of CD8+ T cells within the tumor microenvironment correlates with a favorable prognosis. However, a significant proportion of tumor-infiltrating T cells become trapped within the desmoplastic stroma and lack tumor reactivity. Here, we explored different T-cell subsets in pancreatic tumors and adjacent tissues. We identified a subset of CD8+ T cells, double positive (DP) for CD39 and CD103 in pancreatic tumors, which has recently been described to display tumor reactivity in other types of solid tumors. Interestingly, DP CD8+ T cells preferentially accumulated in central tumor tissues compared with paired peripheral tumor and adjacent non-tumor tissues. Consistent with an antigen encounter, DP CD8+ T cells demonstrated higher proliferative rates and displayed an exhausted phenotype, characterized by elevated expression of PD-1 and TIM-3, compared with CD39−CD103− CD8+ T cells. In addition, DP CD8+ T cells exhibited higher expression levels of the tissue trafficking receptors CCR5 and CXCR6, while displaying lower levels of CXCR3 and CXCR4. Importantly, a high proportion of DP CD8+ T cells is associated with increased patient survival. These findings suggest that DP CD8+ T cells with a phenotype reminiscent of that of tumor-reactive T cells are present in pancreatic tumors. The abundance of DP CD8+ T cells could potentially aid in selecting patients for pancreatic cancer immunotherapy trials.

Significance:
Patients with pancreatic cancer with a high proportion of CD39+CD103+ CD8+ T cells exhibiting a tumor-reactive phenotype have improved survival rates, suggesting their potential utility in selecting candidates for immunotherapy trials.
South African Land Reforms Under the Auspices of the “Radical Economic Transformation”
Authors: Yingi Edwin , Benyera Everisto 
Published: February 2024

Abstract
The land question is an emotive issue across the world. At independence, erstwhile colonies adopted land reforms to address colonial imbalances in landholding. South Africa is one such country that has embarked on land reforms with the view to correcting economic imbalances created by the apartheid past. However, land reform in South Africa has not only been slow but has failed to deal with the twin challenges of poverty and inequality. Using qualitative research design and neoclassical theory, this paper investigates South Africa’s land reforms under the auspices of radical economic transformation. The paper argues that the wholesale expropriation of land without compensation does not fit into the obtaining (neoliberal) economic blueprint that has dominated the country over the years. The call for a radical transformation of landholding rights in the country without structural changes in macroeconomic management remains political rhetoric.
From Lifeline to Weapon: The Role of Companion Animals in the Lives of Entangled Victims
Authors: Atwood Dana 
Published: February 2024

Abstract
Growing evidence suggests that companion animals play a significant role in the lives of victims of domestic abuse. The aim of this paper is to extend this research to include a broader range of domestic abuse victims. Drawing from 45 face-to-face interviews with participants who identify as “entangled victims,” this research evidences a complex and varied relationship between entangled victims and companion animals. In this light, policy changes regarding domestic violence victimization are encouraged. Specifically, changes to the power and control wheel, conceptualization of who constitutes a domestic abuse victim, and intervention strategies recognizing that companion animals can be used as both lifelines and weapons.
Does Viewing Cats and Dogs Influence People’s Mood, Optimism, and the Desire to Have Children?
Authors: Machová Kamila , Flegr Jaroslav 
Published: February 2024

Abstract
Photos of cats and dogs are among the most popular kinds of material on the internet. Our large-scale study (N = 8,865) tested the influence of viewing cat and dog images on the desire to have children, mood, and optimism. The main effects of priming on these three variables were insignificant, both in the general population and subpopulations of cat and dog lovers. Nevertheless, a priming–gender interaction had a slight influence on optimism in the general population. Additionally, liking of companion animals was associated with a lower number of children, whereas keeping of animals was associated with a higher number of children. This may indicate that animals do not decrease the fertility of their keepers as previously suggested, but that having children decreases liking for these animals. Our results showed that the effect of watching cats and dogs might be much weaker than previous studies suggest.
The relationship between flight initiation distance and cognition of urban-living yellow mongooses, Cynictis penicillata
Authors: Müller Mijke , Pillay Neville 
Published: February 2024

Abstract
Reduced flight initiation distance (FID) enables urban-living animals to forage closer to humans, while improved cognitive abilities may be beneficial in assessing the level of danger. We assessed whether yellow mongooses, Cynictis penicillata, which are more tolerant to human disturbances, are also better problem-solvers. Mongooses in two locations (), differing in levels of human contact, were presented with a puzzle-box containing a food incentive. FID was longer in the location with more human contact, but reduced at sites closer to humans. With greater human contact, mongooses fled further from the puzzle box and took longer to recover. Despite differences in tolerance to human disturbance and the subsequent recovery, location did not affect problem-solving efficiency. However, the fear response and recovery time decreased in mongooses with lower tolerance of humans, whereas problem-solving decreased in mongooses that were more tolerant to humans, possibly a result of habituation to the humans.
Divine and Human Hatred in Ancient Egypt
Authors: Joseph Amgad 
Published: February 2024

Abstract
This article examines the conceptualization of hatred as a complicated and intense emotion in the realms of humans and deities in ancient Egypt. It thoroughly discusses the addressees, psychology, effects, justifications, and incitements of hatred, as well as the possibility of the pacification of its feelings. It discusses the attestations of hatred, its perceived consequences and experience by the deities, living and dead humans. The article also examines the phraseology, contextualization, and lexical semantics of hatred in a detailed lexicographical and linguistic analysis.
The addressed research problem strives to ascertain whether deities and humans, either living or dead, manifest the same feelings, purposes, incitements, and justifications of hatred or not. Thus, both the negative and positive connotations of hatred are examined. The methodology followed is to examine and analyse attestations in which hate feelings are demonstrated for a better understanding of the phenomenon. The study comes to the conclusion that hatred in ancient Egypt had positive connotations, in contrast to its present-day negative emotional valence as suggested.
Impact of ginger supplementation on serum PGE2, COX2, and IL-6 in response to exhaustive exercise in female taekwondo athletes
Authors: Karizak S.Z. , Shahnehzad M. , Zar A. 
Published: February 2024

Abstract
Inflammation and muscle soreness sometimes occur after high-intensity exercise in some athletes. This study aimed to determine the effect of a ginger supplement period on serum cyclooxygenase-2 (COX2), prostaglandin E2 (PGE2), and interleukin (IL)-6 in response to exhaustive exercise in female taekwondo athletes. In this semi-experimental study, 24 semi-professional female taekwondo athletes (mean age 19.75 ± 2.03 years, height 160 ± 6 cm, weight 53.99 ± 7.49 kg) were selected voluntarily. Subjects were randomly assigned to the ginger supplement + exhaustive (GE + EE) and exhaustive exercise (EE) groups. 24 doses of 2,000 mg of pure ginger supplement (3 days/week for 8 weeks) were taken in the morning and evening (4 capsules of 500 mg: 2 in the morning and 2 in the evening). Then Bruce’s test was performed as an exhaustive exercise. Blood samples were collected in two stages before and after the intervention, and serum levels of COX2, PGE2, and IL-6 were measured using the Elisa method. T-tests and analysis of variance with repeated measures were used to examine intra-group changes and compare between groups from pre-test to post-test using SPSS version 25 software. The results showed a significant increase in the level of serum COX2 (), and no significant increase in the level of serum PGE2 () and IL-6 () in the EE group compared to baseline levels. Also, there was a significant decrease in the level of serum PGE2 (), COX2 (), and IL-6 () in the group of GE + EE compared to baseline levels. In addition, there was a significant difference between the group of GE + EE and the EE (). GE + EE group, in comparison with the EE group, partially reduced inflammation. Taking 8-weeks of ginger supplementations can effectively reduce muscle inflammation following exhaustive exercise in female taekwondo athletes.
Crowdsourced Meteorological Data to Supplement Limited Official Sources: A Survey and Case Study of Precipitation Monitoring in Guangzhou, China
Authors: Yu Yu , Cao Lei , Ren Zhihua , Xu Yan , Feng Wei , Zhao Licheng 
Published: February 2024

Abstract
Crowdsourced meteorological data may provide a useful supplement to operational observations. However, the willingness of various parties to share their data remains unclear. Here, a survey on data applications was carried out to investigate the willingness to participate in crowdsourcing observations. Of the 21 responses, 71% expressed difficulty in meeting the requirement of data services using only their own observations and revealed that they would be willing to exchange data with other parties under some framework; moreover, 90% expressed a willingness to participate in crowdsourcing observations. The findings suggest that in a way the social foundation of crowdsourcing has been established in China. Additionally, a case study on precipitation monitoring was performed in Guangzhou, the capital city of Guangdong Province, South China. Three sources of hourly measurements were combined after data quality control and calibration and interpolated over Guangzhou (gridded precipitation was based on combined data, and it is referred to as the COM grid). Subsequently, the COM grid was compared with the grid data based only on observations from the China Meteorological Administration using three indices, namely, cumulative precipitation, precipitation intensity, and heavy rain hours. The results indicate that requirement for more observations could benefit from crowdsourced data, especially on uneven terrain and in regions covered by sparse surface stations.
Time to diagnosis in systemic lupus erythematosus: Associated factors and its impact on damage accrual and mortality. Data from a multi-ethnic, multinational Latin American lupus cohort
Authors: Nieto Romina , Quintana Rosana , Zavala-Flores Ernesto , Serrano Rosa , Roberts Karen , Catoggio Luis J , García Mercedes A , Berbotto Guillermo A , Saurit Verónica , Bonfa Eloisa , Borba Eduardo F , Lavras Costallat Lilian T , Da Silva Nilzio A , Sato Emilia I , Tavares Brenol Joao C , Massardo Loreto , Neira Oscar J , Vázquez Gloria , Guibert Toledano Marlene , Pascual-Ramos Virginia , Sauza del Pozo María J , Barile-Fabris Leonor A , Amigo Mary-Carmen , García De La Torre Ignacio , Acevedo-Vásquez Eduardo M , Segami María I , Chacón-Díaz Rosa , Esteva-Spinetti María H , Alarcón Graciela S , Pons-Estel Bernardo A , Pons-Estel Guillermo J 
Published: February 2024

Background Systemic lupus erythematosus (SLE) often mimics symptoms of other diseases, and the interval between symptom onset and diagnosis may be long in some of these patients. Aims: To describe the characteristics associated with the time to SLE diagnosis and its impact on damage accrual and mortality in patients with SLE from a Latin American inception cohort. Methods Patients were from a multi-ethnic, multi-national Latin-American SLE inception cohort. All participating centers had specialized lupus clinics. Socio-demographic, clinical/laboratory, disease activity, damage, and mortality between those with a longer and a shorter time to diagnosis were compared using descriptive statistical tests. Multivariable Cox regression models with damage accrual and mortality as the end points were performed, adjusting for age at SLE diagnosis, gender, ethnicity, level of education, and highest dose of prednisone for damage accrual, plus highest dose of prednisone, baseline SLEDAI, and baseline SDI for mortality. Results Of the 1437 included in these analyses, the median time to diagnosis was 6.0 months (Q1–Q3 2.4–16.2); in 721 (50.2%) the time to diagnosis was longer than 6 months. Patients whose diagnosis took longer than 6 months were more frequently female, older at diagnosis, of Mestizo ethnicity, not having medical insurance, and having “non-classic” SLE symptoms. Longer time to diagnosis had no impact on either damage accrual (HR 1.09, 95% CI 0.93–1.28, p = 0.300) or mortality (HR 1.37, 95% CI 0.88–2.12, p = 0.200). Conclusions In this inception cohort, a maximum time of 24 months with a median of 6 months to SLE diagnosis had no apparent negative impact on disease outcomes (damage accrual and mortality).
Forensic mental health issues for women in contact with the criminal justice system
Authors: Haysom Leigh 
Published: February 2024

Objective This review demonstrates that women who encounter the Australian criminal justice system include some of the most disadvantaged and mentally unwell people in society, particularly Aboriginal women. Women in custody are a heterogeneous group and have different psychosocial needs when compared to male prisoners. Conclusion The approaches to female offending must address their significant psychosocial and mental health issues at every point of contact with the criminal justice system, be culturally informed and specifically address Indigenous overrepresentation.
Metastatic pancreatic carcinoma with neuroendocrine differentiation in a cat
Authors: Berto Aline Nochi , de Lemos Gisele Augusta Amorim , Navolar Felipe Martins Negreiros , Di Santis Giovana Wingeter , Zanutto Marcelo de Souza 
Published: February 2024

Case summary This report describes the case of a 7-year-old male neutered domestic mixed-breed cat that was initially referred to the Veterinary Hospital of the State University of Londrina for evaluation of a 2-week history of abdominal distension and a 2-day history of anorexia, infected with feline immunodeficiency virus (FIV). Abdominal ultrasound revealed an expansive mass located around the pancreas and right hepatic lobe. In the transoperative macroscopic observation, multiple white nodules were visualized in the liver, pancreas, mesentery, intestine, stomach and peritoneal wall. Immunohistochemical examination revealed that neoplastic cells demonstrated a strong positivity for AE1/AE3 and CK20. A sparse immunoreactivity to chromogranin A was observed, which demonstrates neuroendocrine cell labeling. The histopathologic changes associated with the immunohistochemical profile confirmed the diagnosis of metastatic carcinoma with neuroendocrine differentiation, originating from the pancreas. Relevance and novel information Neuroendocrine tumors of the pancreas are rare and are associated with a poor prognosis in humans. In humans, approximately 7% of neuroendocrine tumors develop in the pancreas, and the 5-year survival rate for a pancreatic neuroendocrine tumor is 53%, according to the American Cancer Society. To our knowledge, only one case has been described in the feline species so far. Due to the rarity of this type of tumor in cats, there is little information about predisposition related to age, sex or breed, as well as the main clinical signs presented, survival time and treatment options.
Chloroplast genome analyses of Caragana arborescens and Caragana opulens
Authors: Liu LiE , Li Hongyan , Li Jiaxin , Li Xinjuan , Hu Na , Wang Honglun , Zhou Wu 
Published: February 2024

Abstract
Background
Numerous species within the genus Caragana have high ecological and medicinal value. However, species identification based on morphological characteristics is quite complicated in the genus. To address this issue, we analyzed complete plastid genome data for the genus.

Results
We obtained chloroplast genomes of two species, Caragana arborescens and Caragana opulens, using Illumina sequencing technology, with lengths of 129,473 bp and 132,815 bp, respectively. The absence of inverted repeat sequences in the two species indicated that they could be assigned to the inverted repeat-lacking clade (IRLC). The genomes included 111 distinct genes (4 rRNA genes, 31 tRNA genes, and 76 protein-coding genes). In addition, 16 genes containing introns were identified in the two genomes, the majority of which contained a single intron. Repeat analyses revealed 129 and 229 repeats in C. arborescens and C. opulens, respectively. C. arborescens and C. opulens genomes contained 277 and 265 simple sequence repeats, respectively. The two Caragana species exhibited similar codon usage patterns. rpl20-clpP, rps19-rpl2, and rpl23-ycf2 showed the highest nucleotide diversity (pi). In an analysis of sequence divergence, certain intergenic regions (matK-rbcL, psbM-petN, atpA-psbI, petA-psbL, psbE-petL, and rps7-rps12) were highly variable. A phylogenetic analysis showed that C. arborescens and C. opulens were related and clustered together with four other Caragana species. The genera Astragalus and Caragana were relatively closely related.

Conclusions
The present study provides valuable information about the chloroplast genomes of C. arborescens and C. opulens and lays a foundation for future phylogenetic research and molecular marker development.
Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives
Authors: Schilbert Hanna Marie , Busche Mareike , Sáez Vania , Angeli Andrea , Weisshaar Bernd , Martens Stefan , Stracke Ralf 
Published: February 2024

Abstract
Background
Flavonoids are plant specialised metabolites, which derive from phenylalanine and acetate metabolism. They possess a variety of beneficial characteristics for plants and humans. Several modification steps in the synthesis of tricyclic flavonoids cause for the amazing diversity of flavonoids in plants. The 2-oxoglutarate-dependent dioxygenases (2-ODDs) flavanone 3-hydroxylase (F3H, synonym FHT), flavonol synthase (FLS) and anthocyanidin synthase (ANS, synonym leucoanthocyanidin dioxygenase (LDOX)), catalyse oxidative modifications to the central C ring. They are highly similar and have been shown to catalyse, at least in part, each other’s reactions. FLS and ANS have been identified as bifunctional enzymes in many species, including Arabidopsis thaliana, stressing the capability of plants to bypass missing or mutated reaction steps on the way to flavonoid production. However, little is known about such bypass reactions and the flavonoid composition of plants lacking all three central flavonoid 2-ODDs.

Results
To address this issue, we generated a f3h/fls1/ans mutant, as well as the corresponding double mutants and investigated the flavonoid composition of this mutant collection. The f3h/fls1/ans mutant was further characterised at the genomic level by analysis of a nanopore DNA sequencing generated genome sequence assembly and at the transcriptomic level by RNA-Seq analysis. The mutant collection established, including the novel double mutants f3h/fls1 and f3h/ans, was used to validate and analyse the multifunctionalities of F3H, FLS1, and ANS in planta. Metabolite analyses revealed the accumulation of eriodictyol and additional glycosylated derivatives in mutants carrying the f3h mutant allele, resulting from the conversion of naringenin to eriodictyol by flavonoid 3’-hydroxylase (F3’H) activity.

Conclusions
We describe the in planta multifunctionality of the three central flavonoid 2-ODDs from A. thaliana and identify a bypass in the f3h/fls1/ans triple mutant that leads to the formation of eriodictyol derivatives. As (homo-)eriodictyols are known as bitter taste maskers, the annotated eriodictyol (derivatives) and in particular the observations made on their in planta production, could provide valuable insights for the creation of novel food supplements.