bluuebunny/crossref_metadata_2025_split huggingface dataset:
Життя від поганого запаху
Authors: Stiller-Reeve Mathew , Rosnes Erling , Eilertsen Mari , Ramalho Sofia , Poddevin Victor , Panieri Giuliana , Peftieva Olena 
Published: November 2023

Фокусуємося на:
сірководні, який свідчить про те, що на дні глибокого моря є життя.
Навчальні цілі:
За допомогою цієї діяльності ми створюємо неприємний запах, схожий на сірководень за допомогою гнилої органічної речовини. Використовуємо цей запах як основу для обговорення цікавого життя, істот, харчових мереж на дні глибокого моря.
Ключові слова:
Глибоководне море, сірководень, хемосинтез, нематоди, трубочники, харчові мережі
Форамініфера бугі
Authors: Holm Villads , Losleben Lisa Katrin , Zimmermann Heike Jane , Clerici Monica , Panieri Giuliana , Peftieva Olena 
Published: November 2023

Фокусуємося на:
на форамініферах за допомогою практичних занять та презентації пісні «Форамініфера Бугі». Учні та вчитель також можуть грати на інструментах разом з записаним саундтреком.
Цілі навчання:
У цій діяльності учні будуть практикувати прослуховування один одного та музики. Вони вивчать текст пісні та будуть її співати. Це можна поєднати з грою на реальних музичних інструментах або використати інструменти, які учні створили самостійно (наприклад, див. діяльність «Cold Seeps Symphony»). Це заняття поєднує музику з історією форамініфер.
Ключові слова:
Океан, дослідники, маловідомі істоти Арктичного океану, спільне життя людини та нелюдських істот, планетарний час
Подорож до холодних просочень
Authors: Mohadjer Solmaz , Aune Vibeke , Panieri Giuliana , Oddone Davide , Peftieva Olena 
Published: November 2023

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холодних просоченнях: де вони знаходяться, що там відбувається та як вчені їх вивчають.
Цілі навчання:
Після уроку учні будуть мати змогу:1. Встановлювати зв’язки між різними наборами картографічних даних, спостерігаючи та описуючи наукові карти.2. Розрізняти діоксид вуглецю (вуглекислий газ) та метановий газ.3. Прояснити неправильні уявлення про парникові гази.4. Пояснити, що таке холодні просочення та чому більшість газу / метанових гідратів виникає на континентальних шельфах.5. Описати деякі з методів, якими користуються вчені для локалізації та вивчення метанових / газових гідратів.
Попередні вимоги:
Перед цим уроком учні повинні ознайомитись з тим, як користуватися картами, що таке молекулярна структура та як вона зв’язана, що таке парниковий ефект і парникові гази.
Ключові слова:
Арктичний океан, метан, діоксид вуглецю, газовий гідрат, холодне просочення, парниковий газ.
Діорама океанського дна
Authors: Maric Filip , Poto Margherita Paola , Zimmermann Heike Jane , Panieri Giuliana , Peftieva Olena 
Published: November 2023

Фокусуємося на:
закріпленні знань про дно океану у творчій та веселій формі. Створюючи діораму, учні будуть використовувати знання про те, як виглядає дно океану і які види там живуть.
Мета навчання:
У цій вправі учні сконструюють, класифікують і знайдуть місце для всіх істот і персонажів, які складають дно океану та біорізноманіття, про які вони дізналися на уроці.
Скульптури форамініфер, мікро-, мейо- та макрофауни
Authors: Maric Filip , Poto Margherita Paola , Zimmermann Heike Jane , Panieri Giuliana , Peftieva Olena 
Published: November 2023

Фокусуємося на:
біорізноманітті Північного Льодовитого океану та його дна, приділяючи особливу увагу менш відомим видам, таким як форамініфери. Які види мікро-, мейо-, та макрофауни живуть на дні океану і як вони виглядають?
Мета навчання:
У цій вправі учні визначать (один, два або більше) види форамініфер, що живуть на дні Північного Льодовитого океану або поблизу нього, і виліплять їх за допомогою глини. Учні також зрозуміють відмінності між мікро-, мейо- та макрофауною Північного Льодовитого океану.
Ключові слова:
Форамініфери (бентосні, планктонні), біорізноманіття Північного Льодовитого океану, види, фауна
TMUB1 expression is associated with the prognosis of colon cancer and immune cell infiltration
Authors: Lu Yan , Wang Kang , Peng Yuanhong , Zhang Jun , Ju Qinuo , Xu Qihuan , Ouyang Manzhao , He Zhiwei 
Published: November 2023

Background
TMUB1 is a transmembrane protein involved in biological signaling and plays an important role in the stability and transcription of P53. However, its role in tumor remains unknown.

Methods
Using R language, the expression level of 33 cancer spectrum TMUB1 was analyzed by the public database TCGA, GEO and HPA, the differential expressed gene (DEG) screening and protein interaction (PPI) network was constructed, and the differential genes of TMUB1 in colon cancer were identified. The relevant signaling pathways were identified by gene functional annotation and enrichment analysis. The ssGSEA algorithm in GSVA were used for immune infiltration analysis. The Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, nomogram and calibration map analysis were constructed to evaluate the correlation between TMUB1 expression and clinical prognosis. The expression levels of TMUB1 in intestinal cancer cell lines as well as in 10 intestinal cancer tissues were verified by qPCR experiments.

Results
Through the bioinformatics analysis of multiple databases and preliminary experimental studies, we found that the expression of TMUB1 was significantly increased in colon cancer tumors, and was correlated with the clinical N stage, pathological grade, lymphatic metastasis and BMI of colon cancer. TMUB1 may be involved in the regulation of the malignant progression of colon cancer. Meanwhile, patients with high expression of TMUB1 mRNA had worse OS and DSS, and TMUB1 expression was an independent prognostic factor for OS and DSS. It was further found that highly expressed TMUB1 tissues showed low levels of immune infiltration and stromal infiltration.

Conclusion
We reported the expression level of TMUB1 in colon cancer and analyzed its potential prognostic value in colon cancer through the bioinformatics analysis and preliminary experimental studies. The high expression of TMUB1 is a negative prognostic factor for colon cancer patients. TMUB1 may be a potential target for colon cancer.
How did they get there? A history of koalas on Queensland’s islands
Authors: Danaher Mike , Shanks Benjamin , Jones Benjamin T , Schlagloth Rolf 
Published: November 2023

ABSTRACT
Most Queensland islands today have no koalas, but in the past several islands were inhabited by the iconic marsupial. Using historical research methods, this paper compiles what is known about the arrival of koalas on Queensland islands, both naturally occurring and translocated, and discusses their persistence, current status, environments and threats. Seventeen islands are identified as having a history of koalas with 13 of these islands having once been part of the koala’s natural range. Two of these islands with natural populations plus four unoccupied islands received historical translocations as early as the 1920s and 1930s as a conservation tool or to boost tourism. Currently, 7 of the 17 islands still have koalas. For future research, the paper raises the important question about whether some Queensland islands are suitable habitat sanctuaries for koalas for further translocations.
Self‐Assembled Nano‐CT Contrast Agent Leveraging Size Aggregation for Improved In Vivo Tumor CT Imaging
Authors: Wang Chengcheng , Zhu Jingjing , Wang Shasha , Zhao Lingzhou , Wei Peng , Yi Tao 
Published: November 2023

AbstractComputed tomography (CT) is a widely utilized noninvasive diagnostic tool in clinical practice. However, the commonly employed small molecular iodinated contrast agents (ICAs) in clinical CT imaging have limitations such as nonspecific distribution in body, rapid clearance through kidneys, etc., leading to a narrow imaging time window. In contrast, existing nano‐sized ICAs face challenges like structural uncertainty, poor reproducibility, low iodine content, and uniformity issues. In this study, a novel approach is presented utilizing the aggregation‐induced emission luminogen (AIEgen) to design and fabricate a kind of monocomponent nano‐sized ICA (namely, BioDHU‐CT NPs) that exhibits a unique aggregation effect upon activation. The small sized BioDHU‐CT nanoparticles exhibit excellent tumor targeting capabilities and can release ICA modified with AIEgen with a high release efficiency up to 88.45%, under the activation of reactive oxygen species highly expressed in tumor regions. The released ICA performs in situ aggregation capability in the tumor region, which can enhance the retention efficiency of CT contrast agents, extending the imaging time window and improving the imaging quality in tumor regions.
Type I Photosensitizer Targeting Glycans: Overcoming Biofilm Resistance by Inhibiting the Two‐Component System, Quorum Sensing, and Multidrug Efflux
Authors: Xia Feng‐Wei , Guo Bing‐Wei , Zhao Yu , Wang Jia‐Li , Chen Yuan , Pan Xiu , Li Xin , Song Jia‐Xing , Wan Yu , Feng Shun , Wu Ming‐Yu 
Published: November 2023

AbstractStubborn biofilm infections pose serious threats to human health due to the persistence, recurrence, and dramatically magnified antibiotic resistance. Photodynamic therapy has emerged as a promising approach to combat biofilm. Nevertheless, how to inhibit the bacterial signal transduction system and the efflux pump to conquer biofilm recurrence and resistance remains a challenging and unaddressed issue. Herein, a boric acid‐functionalized lipophilic cationic type I photosensitizer, ACR‐DMP, is developed, which efficiently generates •OH to overcome the hypoxic microenvironment and photodynamically eradicates methicillin‐resistant Staphylococcus aureus (MRSA) and biofilms. Furthermore, it not only alters membrane potential homeostasis and osmotic pressure balance due to its strong binding ability with plasma membrane but also inhibits quorum sensing and the two‐component system, reduces virulence factors, and regulates the activity of the drug efflux pump attributed to the glycan‐targeting ability, helping to prevent biofilm recurrence and conquer biofilm resistance. In vivo, ACR‐DMP successfully obliterates MRSA biofilms attached to implanted medical catheters, alleviates inflammation, and promotes vascularization, thereby combating infections and accelerating wound healing. This work not only provides an efficient strategy to combat stubborn biofilm infections and bacterial multidrug resistance but also offers systematic guidance for the rational design of next‐generation advanced antimicrobial materials.
One Stone, Three Birds: SnO2 Nanosheet Arrays toward Self‐Powered Visible‐Blind UV Photodetection with High Responsivity and Rejection Ratio
Authors: Yu Huan , Shao Zhitao , Wang Yunxia , Xu Yi , Zhang Xiaoyu , Yao Jing , Gao Feng , Hu PingAn , Feng Wei 
Published: November 2023

AbstractPhotoelectrochemical‐type ultraviolet photodetectors (PEC UV PDs) with simple fabrication processes and high sensitivity have attracted ever‐growing attention. However, the self‐powered performance of PEC UV PDs is still unsatisfying. Herein, the SnO2 nanosheet array (NSA) photoanodes are fabricated and their good self‐powered UV detection capability is demonstrated. The 3D structure of SnO2 NSA not only improves the interfacial charge transfer and carrier transport but also enhances UV absorption. Therefore, the self‐powered SnO2 NSA‐based PEC UV PDs exhibit excellent performance with an ultrahigh responsivity of 207.12 mA W−1, an excellent UV–visible rejection ratio (R254/R455 of 3395), a fast response time (25 ms), and good stability under 254 nm illumination, demonstrating one of the recorded‐high‐performance in the recently reported PEC UV PDs. This work provides more options for developing high‐performance PEC UV PDs.
Bottom‐Up Assembly of Inorganic Particle‐Based Chiroptical Materials
Authors: Probst Patrick T. , Dong Yue , Zhou Ziwei , Aftenieva Olha , Fery Andreas 
Published: November 2023

AbstractChiral artificial nanosystems constructed from inorganic nanoparticles brought about a paradigm shift in chiral sensing, enantioselective catalysis, chiral polarization engineering, and chiral emission due to their strong light–matter interaction and their precisely engineered properties. Especially bottom‐up approaches hold great potential for the inexpensive, scalable production of plasmonic, excitonic, and upconversion chiral materials. This perspective first reviews the state‐of‐the‐art fabrication schemes: chiral molecule‐induced chirality, chiral nanoparticle growth, and assembly of chiral superstructures from achiral building blocks. Next, the emerging field of dynamically tunable chiroptical materials, promising for adaptive thin‐film optics, display technologies, and information encoding, is explored. Here, the strength of chiral assemblies based on their rich tuning mechanisms and their ability for geometrical reconfiguration is highlighted. Finally, promising future directions and opportunities in the field of active chiroptical materials are discussed.
Dramatically Enhanced Valley‐Polarized Emission by Alloying and Electrical Tuning of Monolayer WTe2xS2(1‐x) Alloys at Room Temperature with 1T′‐WTe2‐Contact
Authors: Lin Wei‐Hsiang , Li Chia‐Shuo , Wu Chih‐I , Rossman George R. , Atwater Harry A. , Yeh Nai‐Chang 
Published: November 2023

AbstractMonolayer ternary tellurides based on alloying different transition metal dichalcogenides (TMDs) can result in new two‐dimensional (2D) materials ranging from semiconductors to metals and superconductors with tunable optical and electrical properties. Semiconducting WTe2xS2(1‐x) monolayer possesses two inequivalent valleys in the Brillouin zone, each valley coupling selectively with circularly polarized light (CPL). The degree of valley polarization (DVP) under the excitation of CPL represents the purity of valley polarized photoluminescence (PL), a critical parameter for opto‐valleytronic applications. Here, new strategies to efficiently tailor the valley‐polarized PL from semiconducting monolayer WTe2xS2(1‐x) at room temperature (RT) through alloying and back‐gating are presented. The DVP at RT is found to increase drastically from < 5% in WS2 to 40% in WTe0.12S1.88 by Te‐alloying to enhance the spin‐orbit coupling. Further enhancement and control of the DVP from 40% up to 75% is demonstrated by electrostatically doping the monolayer WTe0.12S1.88 via metallic 1T′‐WTe2 electrodes, where the use of 1T′‐WTe2 substantially lowers the Schottky barrier height (SBH) and weakens the Fermi‐level pinning of the electrical contacts. The demonstration of drastically enhanced DVP and electrical tunability in the valley‐polarized emission from 1T′‐WTe2/WTe0.12S1.88 heterostructures paves new pathways towards harnessing valley excitons in ultrathin valleytronic devices for RT applications.
Stepwise and Controllable Synthesis of Mesoporous Heterotrimetallic Catalysts Based on Predesigned Al4Ln4 Metallocycles
Authors: Luo Dan , Liu Chen‐Hui , Chen Yi‐Bo , Wang San‐Tai , Fang Wei‐Hui , Zhang Jian 
Published: November 2023

AbstractThe motivation for making heterometallic compounds stemmed from their emergent synergistic properties and enhanced capabilities for applications. However, the atomically precisely controlled synthesis of heterometallic compounds remains a daunting challenge of the complications that arise when applying several metals and linkers. Herein, a stepwise and controlled method is reported for the accurate addition of second and third metals to homometallic aluminum macrocycles based on the synergistic coordination and hard‐soft acid‐base theory. These heterometallic compounds showed a good Lewis acid catalytic effect, and the addition of hetero‐metals significantly improved the catalytic effect and rate, among that the conversion rate of compound AlOC‐133 reached 99.9% within half an hour. This method combines both the independent controllability of stepwise assembly with the universality of one‐step methods. Based on the large family of clusters, the establishment of this method paves the way for the controllable and customized molecular‐level synthesis of heterometallic materials and creates materials customized for preferential application.
Higher Glycemic Index and Glycemic Load Diet Is Associated with Slower Disease Progression in Amyotrophic Lateral Sclerosis
Authors: Lee Ikjae , Mitsumoto Hiroshi , Lee Seonjoo , Kasarskis Edward , Rosenbaum Michael , Factor‐Litvak Pam , Nieves Jeri W. 
Published: November 2023

ObjectiveHigh‐caloric diets may slow the progression of amyotrophic lateral sclerosis; however, key macronutrients have not been identified. We examined whether dietary macronutrients are associated with the rate of progression and length of survival among the prospective cohort study participants.MethodsParticipants with a confirmed diagnosis of sporadic amyotrophic lateral sclerosis enrolled in the Multicenter Cohort Study of Oxidative Stress were included (n = 304). We evaluated baseline macronutrient intake assessed by food frequency questionnaire in relation to change in revised amyotrophic lateral sclerosis functional rating scale total‐score, and tracheostomy‐free survival using linear regression and Cox proportional hazard models. Baseline age, sex, disease duration, diagnostic certainty, body mass index, bulbar onset, revised amyotrophic lateral sclerosis functional rating scale total‐score, and forced vital capacity were included as covariates.ResultsBaseline higher glycemic index and load were associated with less decline of revised amyotrophic lateral sclerosis functional rating scale total score at 3‐month follow‐up (β = −0.13, 95% CI −0.2, −0.01, p = 0.03) and (β = −0.01, 95% CI −0.03, −0.0007, p = 0.04), respectively. Glycemic index second‐quartile, third‐quartile, and fourth‐quartile groups were associated with less decline at 3 months by 1.9 (95% CI −3.3, −0.5, p = 0.008), 2.0 (95% CI −3.3, −0.6, p = 0.006), and 1.6 (95% CI −3.0, −0.2, p = 0.03) points compared with the first‐quartile group; the glycemic load fourth‐quartile group had 1.4 points less decline compared with the first‐quartile group (95% CI −2.8, 0.1, p = 0.07). Higher glycemic index was associated with a trend toward longer tracheostomy‐free survival (HR 0.97, 95% CI 0.93, 1.00, p = 0.07).InterpretationHigher dietary glycemic index and load are associated with slower disease progression in amyotrophic lateral sclerosis. ANN NEUROL 2024;95:217–229
Relevance of Multiple Sclerosis Severity Genotype in Predicting Disease Course: A Real‐World Cohort
Authors: Kreft Karim L. , Uzochukwu Emeka , Loveless Sam , Willis Mark , Wynford‐Thomas Ray , Harding Katharine E. , Holmans Peter , Lawton Michael , Tallantyre Emma C. , Robertson Neil P. 
Published: November 2023

ObjectiveCurrently, 233 genetic loci are known to be associated with susceptibility to multiple sclerosis (MS). Two independent pivotal severity genome‐wide association studies recently found the first genome‐wide significant single‐nucleotide variant (SNV; rs10191329A) and several other suggestive loci associated with overall disability outcomes. It is now important to understand if these findings can influence individual patient management.MethodsWe assessed whether these progression SNVs are associated with detailed clinical phenotypes in a well‐characterized prospective cohort of 1,455 MS patients. We used logistic regression, survival analysis, and propensity score matching to predict relevant long‐term clinical outcomes.ResultsWe were unable to detect any association between rs10191329A and a range of clinically relevant outcomes (eg, time to Expanded Disability Status Scale milestones, age‐related MS severity score, anatomical localization at onset or during subsequent relapses, annualized relapse rate). In addition, an extremes of outcome case–control analysis using a propensity score matching for genotype detected no association between disease severity and rs10191329A. However, we were able to replicate the association of two suggestive SNVs (rs7289446G and rs868824C) with the development of fixed disability, albeit with modest effect sizes, and the association of HLA‐DRB1*1501 with age at onset.InterpretationIdentification of rs10191329A and other suggestive SNVs are of considerable importance in understanding pathophysiological processes associated with MS severity. However, it is unlikely that individual genotyping can currently be used in a clinical setting to guide disease management. This study shows the importance of independent replication of genome‐wide association studies associated with disease progression in neurodegenerative disorders. ANN NEUROL 2024;95:459–470
Design and Thermodynamics Principles to Program the Cooperativity of Molecular Assemblies
Authors: Lauzon Dominic , Vallée‐Bélisle Alexis 
Published: November 2023

AbstractMost functional nanosystems in living organisms are constructed using multimeric assemblies that provide multiple advantages over their monomeric counterparts such as cooperative or anti‐cooperative responses, integration of multiple signals and self‐regulation. Inspired by these natural nanosystems, chemists have been synthesizing self‐assembled supramolecular systems over the last 50 years with increasing complexity with applications ranging from biosensing, drug delivery, synthetic biology, and system chemistry. Although many advances have been made concerning the design principles of novel molecular architectures and chemistries, little is still known, however, about how to program their dynamic of assembly so that they can assemble at the required concentration and with the right sensitivity. Here, we used synthetic DNA assemblies and double‐mutant cycle analysis to explore the thermodynamic basis to program the cooperativity of molecular assemblies. The results presented here exemplify how programmable molecular assemblies can be efficiently built by fusing interacting domains and optimizing their compaction. They may also provide the rational basis for understanding the thermodynamic and mechanistic principles driving the evolution of multimeric biological complexes.
Tracking Ion Transport in Nanochannels via Transient Single‐Particle Imaging
Authors: Wang Lu‐Xuan , Huang Sheng‐Lan , Wu Pei , Liu Xiao‐Rui , Sun Chao , Kang Bin , Chen Hong‐Yuan , Xu Jing‐Juan 
Published: November 2023

AbstractThe transport behavior of ions in the nanopores has an important impact on the performance of the electrochemical devices. Although the classical Transmission‐Line (TL) model has long been used to describe ion transport in pores, the boundary conditions for the applicability of the TL model remain controversial. Here, we investigated the transport kinetics of different ions, within nanochannels of different lengths, by using transient single‐particle imaging with temporal resolution up to microseconds. We found that the ion transport kinetics within short nanochannels may deviate significantly from the TL model. The reason is that the ion transport under nanoconfinement is composed of multi basic stages, and the kinetics differ much under different stage domination. With the shortening of nanochannels, the electrical double layer (EDL) formation would become the “rate‐determining step” and dominate the apparent ion kinetics. Our results imply that using the TL model directly and treating the in‐pore mobility as an unchanged parameter to estimate the ion transport kinetics in short nanopores/nanochannels may lead to orders of magnitude bias. These findings may advance the understanding of the nanoconfined ion transport and promote the related applications.