bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of classroom-based physical activity on teaching quality of systemic lupus erythematosus for medical undergraduates
Authors: Chen Yong , He Mang , Tian Shidan , Jiang Yan , Zhang Yongqiao , Lin Yupei , Xing Zhouxiong , Nandakumar Kutty Selva , Tian Mei 
Published: January 2024

Objective To explore the influence of classroom-based physical activity (CB-PA) on the teaching quality of systemic lupus erythematosus (SLE) for medical undergraduates. Methods Students from 8 classes participating in the clinical medicine program of the affiliated hospital of Zunyi Medical University were divided into two groups. Four classes received regular teaching on the SLE chapter as the control group, and the other four received CB-PA intervention as the experimental group. After class, the basic ability (diagnostics and pharmacology scores in sophomore year) and teaching quality scores were collected and compared using a questionnaire. The performance of the 2 groups to the SLE review questions was compared. Results The scores of learning interest, the degree of satisfaction with the courses, and the level of mastering the teaching contents in the experimental group were significantly higher than those in the control group. The evaluation of the teacher’s teaching level increased considerably. The experimental group’s performance was also better than the control group’s (the assessment performance was adjusted with the basic ability). Conclusion CB-PA in teaching SLE improves students’ interest in learning, teaching satisfaction, and mastery of knowledge and may ultimately enhance their assessment results.
Implementation of a vascular access team and an intravenous therapy programme: A first-year activity analysis
Authors: Rosich-Soteras Arianna , Bonilla-Serrano Carolina , Llauradó-González Ma Àngels , Fernández-Bombín Alicia , Triviño-López Joselyn Abigail , Barceló-Querol Lluís , Heredia-Aguilar Laura , Frías-Martín Ma Carmen , Valverde-Bosch Montserrat , Corominas-Bosch Ma Lourdes , Domènech Ariadna 
Published: January 2024

Background: Creating Vascular Access Teams (VAT) provides an expert nursing role that contributes to the training and continuous improvement of healthcare personnel. They can offer greater clinical safety, reducing complications and costs. Peripherally inserted central catheters (PICCs) and midline catheters (ML) can be safe and cost-effective alternatives to other types of venous access (VA). The aim of the study was to analyse our centre’s VAT first 12 months of activity. The primary outcome was reported complications. Secondary outcomes were cause of catheter removal, consultancy activity and economic impact of VAT implantation. Methodology: A longitudinal, descriptive study was carried out from March 2019 to March 2020. Using consecutive sampling, all VA inserted, and all consults received were included. Patients under 18 years of age were excluded. Results: The VAT inserted 1257 catheters into 1056 patients (291 MLs, 966 PICCs). The mean dwell time was 14.9 days for MLs and 59.07 days for PICCs. The main reason for removing VA was end of treatment (80.7%). During VA follow-up confirmed infection was detected in 1 ML (0.3%) and nine PICCs (0.9%). Symptomatic thrombosis was reported in 2 MLs (0.7%) and 16 PICCs (1.7%). The VAT received 367 consultations, and the main reason for consultation was to resolve doubts regarding the management of VA (80.9%). The insertion of ML and PICC catheters represented annual estimated economic savings of €867,688.44€. Conclusions: Our study provides a detailed analysis of VAT’s activity, its relevance to clinical safety, and to efficient resource management within our hospital. It demonstrates how VAT establishment can be a safe and efficient intervention that enhances care quality.
Distal AVF creation with marginal calcified radial artery: Multicentric experience of intraoperative intravascular lithotripsy
Authors: Marcello Napoli , Marco Taurisano , Patrizia Covella , Paolo Ria , Silvia Barbarini , Simona Cuna , Antonio De Pascalis 
Published: January 2024

Introduction: The first-choice vascular access to starting dialysis in patients with End Stage Renal Disease (ESRD) is autogenous distal arteriovenous-fistula (AVF) to spare vascular district avoiding proximal fistula complications. One of most significant exclusion criteria to create distal AVF is still now the presence of huge calcification of the feeding artery due to large numbers of early failure (EF) and failure in maturation (FTM). In recent years the possibility to use new devices able to deliver intravascular lithotripsy (IVL) to treat high calcified stenosis could be a possibility to recruit these marginal arteries to create distal AVF. Methods: ESRD patients with totally calcified radial artery wall were enrolled to participate to this prospective, single arm, multicentric study. The selected patients were treated with intraoperative IVL at surgical time, during anastomosis creation to soften calcified radial artery. Patients were followed 1 month after surgery with eco-doppler, for flow and vessels maturation assessment. At 3 month was investigated how many patients have started dialysis treatment with two needle cannulation and good efficiency. Results: Nineteen distal forearm radio-cephalic fistula were built in 19 patients. One-month doppler assessment showed mean AVF flow of 743 ml/min and efferent vein caliper of 6.46 mm. At 3 months 14 patient have started stable 2 needles dialysis (other three patients were not yet dialysis dependent CKD). Were observed one immediate failure, one failure in maturation, and two late failures at 4 and 16 months respectively. Sixteen months primary and secondary patency was 78.9% and 89.5% respectively. Conclusion: These results showed how intraoperative IVL could help to recruit huge calcified marginal artery to create autogenous distal forearm AVF, avoiding proximal AVF, risking distal ischemia syndrome, and sparing vascular district to eventually rebuilt more proximal AVF in future.
Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case–control study
Authors: Murphy Robert , Damasceno Albertino , Reddin Catriona , Hankey Graeme J , Iversen Helle K , Oveisgharan Shahram , Lanas Fernando , Czlonkowska Anna , Langhorne Peter , Ogunniyi Adesola , Wasay Mohammad , Rumboldt Zvonko , Judge Conor , Oguz Aytekin , Mondo Charles , Winter Yaroslav , Rosengren Annika , Pogosova Nana , Avezum Alvaro , Nilanont Yongchai , Penaherrera Ernesto , Xavier Denis , Lopez-Jaramillo Patricio , Wang Xingyu , Yusuf Salim , O’Donnell Martin 
Published: January 2024

Background: The contribution of atrial fibrillation (AF) to the etiology and burden of stroke may vary by country income level. Aims: We examined differences in the prevalence of AF and described variations in the magnitude of the association between AF and ischemic stroke by country income level. Methods: In the INTERSTROKE case–control study, participants with acute first ischemic stroke were recruited across 32 countries. We included 10,363 ischemic stroke cases and 10,333 community or hospital controls who were matched for age, sex, and center. Participants were grouped into high-income (HIC), upper-middle-income (subdivided into two groups—UMIC-1 and UMIC-2), and lower-middle-income (LMIC) countries, based on gross national income. We evaluated the risk factors for AF overall and by country income level, and evaluated the association of AF with ischemic stroke. Results: AF was documented in 11.9% (n = 1235) of cases and 3.2% (n = 328) of controls. Compared to HIC, the prevalence of AF was significantly lower in UMIC-2 (aOR 0.35, 95% CI 0.29–0.41) and LMIC (aOR 0.50, 95% CI 0.41–0.60) on multivariable analysis. Hypertension, female sex, valvular heart disease, and alcohol intake were stronger risk factors for AF in lower-income countries, and obesity a stronger risk factor in higher-income countries. The magnitude of association between AF and ischemic stroke was significantly higher in lower-income countries compared to higher-income countries. The population attributable fraction for AF and stroke varied by region and was 15.7% (95% CI 13.7–17.8) in HIC, 14.6% (95% CI 12.3–17.1) in UMIC-1, 5.7% (95% CI 4.9–6.7) in UMIC-2, and 6.3% (95% CI 5.3–7.3) in LMIC. Conclusion: Risk factors for AF vary by country income level. AF contributes to stroke burden to a greater extent in higher-income countries than in lower-income countries, due to a higher prevalence and despite a lower magnitude of odds ratio.
The significance of dynamic monitoring plasma TMAO level in pulmonary arterial hypertension – a cohort study
Authors: Yang Yicheng , Li Xin , Wang Peizhi , Shu Songren , Liu Bingyang , Liang Yanru , Yang Beilan , Zhao Zhihui , Luo Qin , Liu Zhihong , Zheng Lemin , Zeng Qixian , Xiong Changming 
Published: January 2024

Background: Gut microbiota assumes an essential role in the development and progression of pulmonary arterial hypertension (PAH). Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite, is correlated with the prognosis of patients with PAH. However, the correlation between changes in TMAO (ΔTMAO) and the prognosis of PAH remains elusive. Objectives: To investigate the association between ΔTMAO and prognosis of PAH, and explore whether dynamic assessment of TMAO level was superior to measurement at a single time point in predicting prognosis. Design: Single-center cohort study. Methods: Consecutive patients diagnosed with PAH and had at least two TMAO measurements taken from May 2019 to June 2020 were eligible. The outcome events of this study were defined as adverse clinical events. Results: A total of 117 patients with PAH who had two TMAO measurements and follow-up were included in this study. Patients with ΔTMAO ⩾1.082 μmol/L had over four times increased risk of adverse clinical events than their counterparts after adjusting for confounders [hazard ratio (HR) 4.050, 95% confidence interval (CI): 1.468–11.174; p = 0.007]. Patients with constant high TMAO levels at both time points had the highest risk of adverse clinical events compared with patients with constant low TMAO levels (HR 3.717, 95% CI: 1.627–8.492; p = 0.002). ΔTMAO was also associated with changes in parameters reflecting PAH severity ( p < 0.05). Conclusion: Changes in TMAO were independently correlated with prognosis in patients with PAH, irrespective of baseline level of TMAO. ΔTMAO also correlated with alteration in disease severity. Repeated assessment of TMAO level contributes to better identification of patients with increased risk of adverse clinical events.
Surgical management of recurrent instability following Latarjet procedure – A systematic review of salvage procedures
Authors: Baur Alexander , Satalich James , O’Connell Robert , Vap Alexander 
Published: January 2024

Background Failed Latarjet procedures pose a surgical challenge due to complex anatomical issues. This systematic review investigates salvage techniques for recurrent instability following a Latarjet procedure. Methods A search was conducted on MEDLINE and PubMed Central following the methodology registered to International Prospective Register of Systematic Reviews. Inclusion criteria focused on identifying revision procedures following a Latarjet procedure. Exclusion criteria filtered out irrelevant studies, such as those focused on Bankart procedures. After a multistage selection process, 10 eligible studies were included for data extraction. Results The most frequently utilized technique for salvage was variations of the Eden–Hybinette procedure. Complications associated with these salvage procedures include graft-related problems and donor site morbidity. Patients reported significant improvements in multiple patient-reported outcome scores, and multiple studies indicated high rates of return to sports activities. However, it is noteworthy that there remains an average recurrence rate of 7%. Discussion The review emphasizes the limited therapeutic options available largely due to shoulder anatomy alterations. Despite promising trends in patient-reported outcomes, recurrence remains possible post-salvage surgeries. Conclusion Addressing recurrent instability after a Latarjet procedure continues to be a unique surgical challenge. However, this systematic review highlights encouraging indications, with positive trends evident in patient-reported outcomes.
Wage Differentials and Inequality in Managerial and Professional Jobs: Quantile Regression Analysis
Authors: Muniyoor Krishna , M Aishwarya , Sarma Angana Parashar 
Published: January 2024

In the economics literature, it is vividly portrayed that there is a great deal of disparity in wages received by workers across economic activities and occupations in India. The primary purpose of this article is to identify factors determining wage differentials and to measure wage inequality in managerial and professional occupations. Using unit-level records of periodic labour force survey (PLFS) published by the National Sample Survey Office (NSSO), we apply quantile regression model to examine how wage distribution is determined by personal, household and labour market characteristics. Our analysis is limited to persons aged between 15 and 65 and employed in managerial and professional occupations. The findings suggest that rural–urban dichotomy, gender, technical education, social group, job contract, type of enterprise and enterprise workforce size are statistically significant across quantiles and are important in explaining the wage distribution of managerial and professional workers in India. From a policy perspective, the invigoration of gender-based measures coupled with the expansion of technical education and labour market institutions are essential for bridging the wage disparity in India. JEL Classifications: J16, J24, J31
KBTBD4-mediated reduction of MYC is critical for hematopoietic stem cell expansion upon UM171 treatment
Authors: Chagraoui Jalila , Girard Simon , Mallinger Laure , Mayotte Nadine , Tellechea Maria Florencia , Sauvageau Guy 
Published: January 2024

Abstract
Ex vivo expansion of hematopoietic stem cells (HSCs) is gaining importance for cell and gene therapy, and requires a shift from dormancy state to activation and cycling. However, abnormal or excessive HSC activation results in reduced self-renewal ability and increased propensity for myeloid-biased differentiation. We now report that activation of the E3 ligase complex CRL3KBTBD4 by UM171 not only induces epigenetic changes through CoREST1 degradation but also controls chromatin-bound master regulator of cell cycle entry and proliferative metabolism (MYC) levels to prevent excessive activation and maintain lympho-myeloid potential of expanded populations. Furthermore, reconstitution activity and multipotency of UM171-treated HSCs are specifically compromised when MYC levels are experimentally increased despite degradation of CoREST1.
High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study
Authors: Morelli Vânia M. , Snir Omri , Hindberg Kristian Dalsbø , Hveem Kristian , Brækkan Sigrid K. , Hansen John-Bjarne 
Published: January 2024

Abstract
MicroRNA-145 (miR-145) has been reported to downregulate the expression of tissue factor and factor XI in vitro and decrease venous thrombus formation in animal models. However, the association between miR-145 and risk of future venous thromboembolism (VTE) in the general population remains unknown. We investigated the association between plasma levels of miR-145 and risk of future VTE in a case-cohort study. Incident VTE cases (n = 510) and a subcohort (n = 1890) were derived from the third survey of the Trøndelag Health Study (HUNT3), a population-based cohort. The expression levels of miR-145 were measured in plasma samples obtained at baseline. The study population was divided into quartiles based on miR-145 levels in participants in the subcohort, and weighted Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Plasma levels of miR-145 were inversely associated with VTE risk. Participants with miR-145 levels in the highest quartile had a 49% lower risk of VTE (HR, 0.51; 95% CI, 0.38-0.68) than those with miR-145 in the lowest quartile in age- and sex-adjusted analysis, and the inverse association was most pronounced for unprovoked VTE (HR, 0.39; 95% CI, 0.25-0.61). Risk estimates remained virtually the same after further adjustment for body mass index, and cancer and arterial cardiovascular disease at baseline. In conclusion, elevated expression levels of miR-145 in plasma were associated with decreased risk of future incident VTE. The protective role of miR-145 against VTE is consistent with previous experimental data and suggests that miR-145 has the potential to be a target for VTE prevention.
Patterns of progression after immune checkpoint inhibitors for Hodgkin lymphoma: implications for radiation therapy
Authors: Burlile Jessica F. , Frechette Kelsey M. , Breen William G. , Hwang Steven R. , Higgins Alexandra S. , Nedved Adrienne N. , Harmsen William S. , Pulsipher Sydney D. , Witzig Thomas E. , Micallef Ivana N. , Hoppe Bradford S. , Habermann Thomas M. , Thanarajasingam Gita , Johnston Patrick B. , Inwards David J. , Bennani N. Nora , Peterson Jennifer L. , Stish Bradley J. , Rule William G. , Ansell Stephen M. , Lester Scott C. 
Published: January 2024

Abstract
Immune checkpoint inhibitors (ICIs) have demonstrated remarkable response rates in relapsed or refractory Hodgkin lymphoma (HL). Still, most patients eventually progress. Patterns of progression after ICIs are not well described and are essential to defining the role of local therapies in combination with ICIs. We identified patients who received ICIs for HL between 2013 and 2022. Fludeoxyglucose-18 positron emission tomography (FDG-PET) before initiating ICI and at progression on/after ICI were reviewed, and areas of active HL were recorded. An exploratory analysis of treatable progression included patients with ≤5 sites of disease on pre-ICI FDG-PET and progression only at pre-ICI sites. Ninety patients were identified; 69 had complete records, and of these, 32 (52%) had relapsed at ICI initiation, 17 (25%) were refractory, and 16 (23%) received ICI as first-line therapy. Forty-five of 69 patients had ≤5 sites of disease (limited) on pre-ICI FDG-PET. Patients with &gt;5 sites of disease had a higher risk of progression, and every site of disease &gt;5 sites conferred an additional 1.2x higher chance of progression. At a median follow-up of 4.0 years, 41 of 69 patients had progressed on/after ICIs (cumulative incidence 66.4%), and of these, 22 of 41 patients progressed only at pre-ICI sites (cumulative incidence 39.4%). In an exploratory analysis, the cumulative incidence of a treatable progression among 45 patients with limited disease was 34%. The cumulative incidence of any progression among this cohort was 58.9%. More than one-third of patients with limited disease before ICIs experienced progression only at pre-ICI sites of disease. These patients could be candidates for radiation during or after ICIs.
Prevalence, incidence and healthcare burden of eosinophilic granulomatosis with polyangiitis in the UK
Authors: Hwee Jeremiah , Harper Lorraine , Fu Qinggong , Nirantharakumar Krishnarajah , Mu George , Jakes Rupert W. 
Published: January 2024

BackgroundEosinophilic granulomatosis with polyangiitis (EGPA) is a rare but serious disease characterised by the combination of small-to-medium vessel vasculitis, blood and tissue eosinophilia, and asthma and/or sinonasal disease. This study estimated the prevalence and incidence of diagnosed EGPA in the United Kingdom (UK), and described the demographics, clinical characteristics and healthcare resource utilisation (HCRU) of this population.MethodsThis retrospective longitudinal study of patients with newly diagnosed EGPA (index) (2005–2019) used the Clinical Practice Research Datalink AURUM and Hospital Episode Statistics databases. The primary outcomes were the annual prevalence (2005–2019) and incidence (2006–2019) of EGPA, and secondary outcomes included patient demographics and clinical characteristics, and HCRU in the year pre- and post-index (diagnosis).ResultsPopulations of patients with EGPA comprised 940 prevalent cases and 502 incident cases, of which 377 were linked to Hospital Episode Statistics. EGPA prevalence increased from 22.7 to 45.6 cases per 1 000 000 (2005–2019), driven by patients aged ≥18 years. Incidence ranged from 2.3 to 4.0 per 1 000 000 person-years (2006–2019). Pre-index, the most common clinical symptoms were respiratory related, and the most common comorbidities were asthma (80.6%) and nasal polyps (32.1%). Post-index, 19.1% had an EGPA-related inpatient stay (median length of stay 11.0 days) and 38.7% had five or more oral corticosteroid (OCS) prescriptions with a mean OCS possession ratio per patient of 47.0%.ConclusionsAlthough EGPA incidence in the UK remains relatively stable, prevalence is increasing, and HCRU and OCS use remain frequent, suggesting considerable healthcare burden for patients with EGPA.
Sleep apnoea increases biomarkers of immune evasion, lymphangiogenesis and tumour cell aggressiveness in high-risk patients and those with established lung cancer
Authors: Cubillos-Zapata Carolina , Troncoso-Acevedo Fernanda , Díaz-García Elena , Alfaro Enrique , Gotera-Rivera Carolina , Pérez-Warnisher Teresa , Peces-Barba Germán , Seijo Luis M. , García-Río Francisco 
Published: January 2024

BackgroundIntermittent hypoxaemia and obstructive sleep apnoea (OSA) have been linked to lung cancer through as yet unidentified pathophysiological mechanisms. This study evaluates the effect of OSA on serum levels of biomarkers of immunosurveillance, lymphangiogenesis and intrinsic tumour cell aggressiveness in high-risk individuals screened for lung cancer and patients with established lung cancer.MethodsSerum samples from individuals participating in a lung cancer screening cohort (SAILS study) or with newly diagnosed lung cancer (SAIL study) were analysed. All patients underwent home sleep apnoea testing. Soluble levels of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), cytotoxic T-lymphocyte antigen-4, midkine (MDK), paraspeckle component-1 (PSPC1), transforming growth factor-β1 (TGF-β1), SMAD3, matrix metalloproteinase-2 and co-stimulus receptor of the tumour necrosis factor family of receptors (CD137) were determined by ELISA.ResultsThe presence of moderate-to-severe OSA was associated with increased levels of PSPC1, MDK, PD-L1 and PD-1 in screened individuals, and with higher values of PSPC1, TGF-β1, PD-L1 and PD-1 in patients with established lung cancer. The findings correlated with nocturnal intermittent hypoxaemia indices.ConclusionModerate-to-severe OSA is associated with increased expression of serum biomarkers of immune evasion, lymphangiogenesis and tumour cell aggressiveness in high-risk individuals screened for lung cancer and those with established disease.