bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diallylacylhydrazines as Monomers for Polyfunctional Water‐Soluble Polymers.
Authors: Gusev V. Yu. , Vorob'eva A. I. , Radushev A. V. , Kolesov S. V. , Muslukhov R. R. , Tolstikov A. G. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Preparation of Propargylic or Allenylic Sulfides from Propargyl Halides or Mesylate and Thiols.
Authors: Tsutsumi Ken , Fujimoto Kouji , Yabukami Tomomi , Kawase Tomohiro , Morimoto Tsumoru , Kakiuchi Kiyomi 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diels—Alder Reactions of 4‐Triflyloxy‐2,6,6‐trimethyl‐2,4‐cyclohexadienone. An Expedient Methodology for the Synthesis of Bicyclo[2.2.2]oct‐5‐en‐2‐ones and Bicyclo[2.2.2]octa‐5,7‐dien‐2‐ones.
Authors: Lin Yu‐Shiang , Chang Shi‐Yi , Yang Ming‐Shyong , Rao Chitneni Prasad , Peddinti Rama Krishna , Tsai Yow‐Fu , Liao Chun‐Chen 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nucleophilic Displacement at Benzhydryl Centers: Asymmetric Synthesis of 1,1,Diarylalkyl Derivatives.
Authors: Bolshan Yuri , Chen Cheng‐yi , Chilenski Jennifer R. , Gosselin Francis , Mathre David J. , O'Shea Paul D. , Roy Amelie , Tillyer Richard D. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Electrochemical Reduction of Monothiobenzils in the Presence of Aroyl Chlorides. First Synthesis of (Z)‐α‐Benzoyloxy‐β‐benzoylthiostilbenes.
Authors: Guirado Antonio , LopezSanchez Enrique , Andreu Raquel , Zapata Andres 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Cross‐Coupling of Stereospecific Potassium Cyclopropyl Trifluoroborates with Aryl Bromides.
Authors: Fang Guo‐Hua , Yan Zheng‐Jun , Deng Min‐Zhi 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Iodotrimethylsilane‐Mediated Cross‐Aldol Condensation: A Facile Synthesis of α,α′‐Bis(substituted benzylidene)cycloalkanones.
Authors: Sabitha Gowravaram , Reddy G. S. Kiran Kumar , Reddy K. Bhaska , Yadav J. S. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Class of Potent Non‐imidazole H3 Antagonists: 2‐Aminoethylbenzofurans.
Authors: Cowart Marlon , Pratt John K. , Stewart Andrew O. , Bennani Youssef L. , Esbenshade Timothy A. , Hancock Arthur A. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Discovery and SAR Development of 2‐(Phenylamino)imidazolines as Postacyclin Receptor Antagonists.
Authors: Clark Robin D. , Jahangir Alam , Severance Daniel , Salazar Rick , Chang Thomas , Chang David , Jett Mary Frances , Smith Steven , Bley Keith 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Antiinflammatory and Analgesic Activity Screening of Some New 4(3H)‐Quinazolinone Derivatives.
Authors: Yesilada Akguel , Koyunoglu Semra , Saygili Nezire , Kupeli Esra , Yesilada Erdem , Bedir Erdal , Khan Ikhlas 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Copper Triflate as a Useful Catalyst for the High‐Yielding Preparation of α‐Acetyloxyphosphonates under Solvent‐Free Conditions.
Authors: Firouzabadi Habib , Iranpoor Nasser , Sobhani Sara , Amoozgar Zohreh 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cyclic Amidine Sugars as Transition‐State Analogue Inhibitors of Glycosidases: Potent Competitive Inhibitors of Mannosidases.
Authors: Heck Marie‐Pierre , Vincent Stephane P. , Murray Brion W. , Bellamy Francois , Wong Chi‐Huey , Mioskowski Charles 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Structure—Activity Relationships of Non‐imidazole H3 Receptor Ligands. Part 3. 5‐Substituted 3‐Phenyl‐1,2,4‐oxadiazoles as Potent Antagonists.
Authors: Gfesser Gregory A. , et al. et al. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Redox‐Active Cobalt Complexes as Promising Antitumor Agents.
Authors: Osinsky S. P. , Levitin I. Ya. , Sigan A. L. , Bubnovskaya L. N. , Ganusevich I. I. , Campanella L. , Wardman P. 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Azomethine, Carbonyl and Thiocarbonyl Ylides—Generation of Thiocarbonyl Ylides by Elimination of Nitrogen from 2,5‐Dihydro‐1,3,4‐thiadiazoles (Δ3‐1,3,4‐thiadiazolines)
Authors: Mloston Grzegorz 
Published: May 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Measuring social impacts of breast carcinoma treatment in Chinese women
Authors: Fielding Richard , Lam Wendy W. T. 
Published: May 2004

AbstractBACKGROUNDThere is no existing instrument that is suitable for measuring the social impact of breast carcinoma (BC) and its treatment among women of Southern Chinese descent. In the current study, the authors assessed the validity of the Chinese Social Adjustment Scale, which was designed to address the need for such an instrument.METHODSFive dimensions of social concern were identified in a previous study of Cantonese‐speaking Chinese women with BC; these dimensions were family and other relationships, intimacy, private self‐image, and public self‐image. The authors designed 40 items to address perceptions of change in these areas. These items were administered to a group of 226 women who had received treatment for BC, and factor analysis subsequently was performed to determine construct characteristics. The resulting draft instrument then was administered, along with other measures for the assessment of basic psychometric properties, to a second group of 367 women who recently had undergone surgery for BC.RESULTSFactor analysis optimally identified 5 factors (corresponding to 33 items): 1) Relationships with Family (10 items, accounting for 22% of variance); 2) Self‐Image (7 items, accounting for 15% of variance); 3) Relationships with Friends (7 items, accounting for 8% of variance); 4) Social Enjoyment (4 items, accounting for 6% of variance); and 5) Attractiveness & Sexuality (5 items, accounting for 5% of variance). Subscales were reliable (α = 0.63–0.93) and exhibited convergent validity in positive correlations with related measures and divergent validity in appropriate inverse or nonsignificant correlations with other measures. Criterion validity was good, and sensitivity was acceptable. Patterns of change on the scales were consistent with reports in the literature. Self‐administration resulted in improved sensitivity.CONCLUSIONSThe 33‐item Chinese Social Adjustment Scale validly, reliably, and sensitively measures the social impact of BC on Cantonese‐speaking Hong Kong Chinese women. Further development of the scale to increase its sensitivity is underway. Cancer 2004. © 2004 American Cancer Society.
αB‐crystallin as a marker of lymph node involvement in breast carcinoma
Authors: Chelouche‐Lev Dina , Kluger Harriet M. , Berger Aaron J. , Rimm David L. , Price Janet E. 
Published: May 2004

AbstractBACKGROUNDIt was found previously that αB‐crystallin, a small heat‐shock protein, was overexpressed in a metastatic variant of the GI101A human breast carcinoma cell line. The objective of the current study was to determine whether the expression of αB‐crystallin in primary breast carcinomas was associated with lymph node metastasis and survival.METHODSExpression of αB‐crystallin was measured in human breast carcinoma cell lines by immunoblotting. Expression in human breast carcinomas was evaluated by immunohistochemical staining of tissue microarrays that contained samples from 317 patients with lymph node–negative breast carcinoma and 291 patients with lymph node–positive breast carcinoma.RESULTSIt was found that αB‐crystallin was expressed constitutively in certain breast carcinoma cell lines, including those that were capable of metastasizing in immunodeficient mice. Expression of αB‐crystallin in human tissue samples was associated strongly with lymph node involvement (P < 0.0001; chi‐square test) and, to a lesser degree, with high nuclear grade (P = 0.05). Increased intensity of expression was correlated with shorter survival (P = 0.0091; log‐rank test). Multivariate analysis indicated that αB‐crystallin expression was not independent of lymph node status as a predictor of survival.CONCLUSIONSThe data obtained in the current study revealed a strong association between high expression levels of αB‐crystallin in primary breast carcinoma specimens and lymph node involvement. Further studies will be needed to prospectively elucidate the role of this novel tumor marker as a clinical prognostic marker in local and locally advanced breast carcinoma as well as its potential status as a new target for therapy in patients with breast carcinoma. Cancer 2004. © 2004 American Cancer Society.
spoonbill, a new Drosophila female‐sterile mutation, interferes with chromosome organization and dorsal–ventral patterning of the egg
Authors: Motola Shmulik , Neuman‐Silberberg F. Shira 
Published: May 2004

AbstractWe have identified a new mutation, spoonbill (spoon), which interferes with two developmental processes during Drosophila oogenesis, nurse cell‐nuclei chromatin organization and anterior–dorsal patterning of the eggshell. Here, we describe the localization patterns of key regulators of axis determination and the expression of follicle cell‐specific markers involved in eggshell patterning in egg chambers from spoonbill females. Our molecular characterization of the patterning defects associated with the mutation reveals abnormalities in two major signaling pathways, the grk/Egfr and the Dpp/TGF‐β, that together control the elaborate patterning of the anterior follicular epithelium. The function of spoonbill appears to be required for dpp transcription in a specialized population of follicle cells and for the selective transport of grk mRNA from the nurse cells into the oocyte, as well as for its proper localization and translation. This finding places the spoonbill gene upstream of both pathways. Developmental Dynamics 230:535–545, 2004. © 2004 Wiley‐Liss, Inc.
Zinc finger gene fez‐like functions in the formation of subplate neurons and thalamocortical axons
Authors: Hirata Tustomu , Suda Yoko , Nakao Kazuki , Narimatsu Masahiro , Hirano Toshio , Hibi Masahiko 
Published: May 2004

Abstractfez‐like (fezl) is a forebrain‐expressed zinc finger gene required for the formation of the hypothalamic dopaminergic and serotonergic (monoaminergic) neurons in zebrafish. To reveal its function in mammals, we analyzed the expression of the mouse orthologue of fezl and generated fezl‐deficient mice by homologous recombination. Mouse fezl was expressed specifically in the forebrain from embryonic day 8.5. At mid‐gestation, fezl expression was detected in subdomains of the forebrain, including the dorsal telencephalon and ventral diencephalon. Unlike the zebrafish fezl mutant too few, the fezl‐deficient mice displayed normal development of hypothalamic monoaminergic neurons, but showed abnormal “hyperactive” behavior. In fezl−/− mice, the thalamocortical axons (TCA) were reduced in number and aberrantly projected to the cortex. These mutants had a reduced number of subplate neurons, which are involved in guiding the TCA from the dorsal thalamus, although the subplate neurons were born normally. These results suggest that fezl is required for differentiation or survival of the subplate neurons, and reduction of the subplate neurons in fezl‐deficient mice leads to abnormal development of the TCA, providing a possible link between the transcriptional regulation of forebrain development and hyperactive behavior. Developmental Dynamics 230:546–556, 2004. © 2004 Wiley‐Liss, Inc.
Functional and hierarchical interactions among zebrafish vox/vent homeobox genes
Authors: Gilardelli Claudio N. , Pozzoli Ombretta , Sordino Paolo , Matassi Giorgio , Cotelli Franco 
Published: May 2004

AbstractThe vertebrate Vox/Vent family of transcription factors plays a crucial role in the establishment of the dorsoventral (DV) axis, by repressing organizer genes such as bozozok/dharma, goosecoid, and chordino. In Danio rerio (zebrafish), members of the vox/vent gene family (vox/vega1, vent/vega2, and ved) are thought to share expression patterns and functional properties. Bringing novel insights in the differential activity of the zebrafish vox/vent genes, we propose a critical role for the ved gene in DV patterning of vertebrate embryos. ved is not only expressed as a maternal gene, but it also appears to function as a repressor of dorsal factors involved in organizer formation. At early‐ and mid‐gastrula stage, ved appears to be finely controlled by antagonist crosstalks in a complex regulatory network, involving gradients of bone morphogenetic protein (BMP) activity, dorsal factors, and vox/vent family members. We show that ved transcripts are ventrally restricted by BMP factors such as bmp2b, bmp7, smad5, and alk8, and by dorsal factors (chd and gsc). Alteration of ved expression in both vox and vent deletion mutants and vox and vent mRNAs‐injected embryos, suggests that vox and vent function downstream of BMP signaling to negatively regulate ved expression. This inhibitory role is emphasized by a vox and vent redundant activity, compared with single gene effects. Developmental Dynamics 230:494–508, 2004. © 2004 Wiley‐Liss, Inc.
Isoforms vatB1 and vatB2 of the vacuolar type ATPase subunit B are differentially expressed in embryos of the zebrafish (Danio rerio)
Authors: Schredelseker Johann , Pelster Bernd 
Published: May 2004

AbstractThe v‐type ATPase is a membrane anchored, multi‐subunit proton pump, which in freshwater fish appears to play a major role in ionoregulative processes in the apical membrane of specialized gill cells. Very little is known about free‐living fish embryos and larvae that are exposed to hypo‐osmotic conditions with spawning but do not have their gills fully developed. By using reverse transcriptase‐polymerase chain reaction and immunological methods, we could demonstrate the presence of two isoforms of the subunit B of this v‐type ATPase in the early development of the zebrafish. Immunohistochemical analysis revealed the presence of one isoform (vatB1) in the apical membrane of embryonic skin cells, while vatB2 has been found ubiquitously. This differential localization of the two isoforms supports the hypothesis that vatB1 is preferentially involved in ionoregulative functions, while vatB2 may be preferentially responsible for acidification of intracellular vesicles. Developmental Dynamics 230:569–575, 2004. © 2004 Wiley‐Liss, Inc.
Expression of tbx20 RNA during chick heart development
Authors: Yamagishi Toshiyuki , Nakajima Yuji , Nishimatsu Shin‐Ichiro , Nohno Tsutomu , Ando Katsumi , Nakamura Hiroaki 
Published: May 2004

AbstractThe T‐box gene family encodes a set of transcription factors that are involved in various developmental processes. We isolated tbx20 gene from chick embryos and examined in detail its expression patterns during heart development. In situ hybridization showed that tbx20 was expressed in the lateral plate mesoderm and subsequently in the primitive heart tube. At stages of looped heart, tbx20 was localized in the outflow tract (OT) and atrioventricular (AV) canal, in which valvuloseptal endocardial cushion develops. At later stages, although tbx20 was expressed predominantly in the nascent right ventricle, transcripts of tbx20 were down‐regulated in the left ventricle. These results suggest that tbx20 may play important roles in a variety of developmental processes in cardiogenesis, such as chamber‐specification and septation. Developmental Dynamics 230:576–580, 2004. © 2004 Wiley‐Liss, Inc.
Formation of Large Clusters in the Reaction of Lanthanide Cations with Heptamolybdate
Authors: Burgemeister Katja , Drewes Daniel , Limanski Eva Melanie , Küper Ina , Krebs Bernt 
Published: May 2004

AbstractA series of new lanthanide polyoxomolybdates was synthesised by reaction of lanthanide cations with the heptamolybdate anion (Mo7O24)6−. The heteropolyanions [Ln4(MoO4)(H2O)16(Mo7O24)4]14− (Ln = LaIII, CeIII, PrIII, SmIII, GdIII) were isolated as either their ammonium or tetramethylammonium salts and characterised by X‐ray structure analysis, energy dispersive X‐ray fluorescence analysis, and IR and Raman spectroscopy. The central [Ln4(MoO4)(H2O)16]10+ core of the anion is coordinated by four heptamolybdate groups. Each LnIII atom in the core exhibits ninefold coordination by oxygen atoms belonging to H2O, (MoO4)2− and (Mo7O24)6− units; the central molybdenum atom is coordinated tetrahedrally by four oxygen atoms. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Synthesis of Cycloalkanoindoles by an Unusual DAST‐Triggered Rearrangement Reaction
Authors: Giannini Giuseppe , Marzi Mauro , Moretti Gian Piero , Penco Sergio , Tinti Maria Ornella , Pesci Silvia , Lazzaro Francesco , De Angelis Francesco 
Published: May 2004

AbstractA series of 1,1‐bis(indol‐3‐yl) and 1‐(indol‐2‐yl)‐1‐(indol‐3‐yl)‐ψ‐hydroxyalkanes, prepared from the corresponding indole derivatives and suitable hydroxyaldehydes via routine coupling reactions, were treated with DAST (diethylaminosulfur trifluoride) under mild conditions, to generate a small library of cycloalkanoindoles. Irrespective of the substitution pattern, i.e. whether they are symmetrical or unsymmetrical derivatives, the same mixture of products is produced, in which the tetrahydro‐1H‐carbazole and hexahydrocyclohepta[b]indole scaffolds are substituted by a indol‐3‐yl nucleus on one of the two α‐carbon atoms of the cycloalkane moieties. Thus, speculations on the reaction mechanism with the prediction of a common reaction intermediate are presented. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Stereoselective Addition of Sulfone Carbanions to C=N: A Critical Dependence on the Stability and Reactivity of the Amide Anions in MIRC Reactions
Authors: Hassner Alfred , Usak Diana , Kumareswaran Ramaiah , Friedman Oded 
Published: May 2004

AbstractA procedure was developed for the selective synthesis of functionalized 4‐methylenepyrrolidines by tuning the electron‐withdrawing group (ArSO2, COOEt, ArSO) attached to the acceptor imine nitrogen atom during addition of allyl sulfone carbanions. Sulfone carbanion additions to 2H‐azirines were also examined. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
2,3,6,7,10,11‐Hexamethoxytribenzotriquinacene: Synthesis, Solid‐State Structure, and Functionalization of a Rigid Analogue of Cyclotriveratrylene
Authors: Harig Marco , Neumann Beate , Stammler Hans‐Georg , Kuck Dietmar 
Published: May 2004

AbstractThe syntheses of several tribenzotriquinacenes bearing six methoxy groups at the outer peripheral positions of the aromatic rings are reported. The centro‐methyl derivative is accessible in surprisingly good yield through two‐fold cyclodehydration in the final step of a synthesis route which requires special care in the preparation of some electron‐rich key intermediates, such as 5,6‐dimethoxy‐2‐methylindane‐1,3‐dione and bis(3,4‐dimethoxyphenyl)methanol. X‐ray single‐crystal structure analysis of the centro‐methyl derivative confirms its C3v‐symmetrical molecular structure but, at variance from the parent centro‐methyltribenzotriquinacene and the similarly shaped cyclotriveratrylene, the hexamethoxytribenzotriquinacene analog does not form columnar stacks in the solid state. Functionalization of the three benzhydrylic bridgehead positions leads to the tetramethyl analog and the bridgehead triol in good yields. In contrast, attempts to functionalize the ortho positions by nitration or bromination mainly give rise to ring cleavage through electrophilic ipso attack, which parallels the behavior of cyclotribenzylenes and cyclotriveratrylenes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
The Conformation of Alkyl Benzyl Alcohols Studied by ab initio MO Calculations − A Comparison with IR and NMR Spectroscopic Data
Authors: Takahashi Osamu , Saito Ko , Kohno Yuji , Suezawa Hiroko , Ishihara Shinji , Nishio Motohiro 
Published: May 2004

AbstractAb initio MO calculations were carried out for the conformations of a series of alkyl‐substituted benzyl alcohols C6H5CH2CHOH−R (R = CH3, C2H5, iPr, tBu) at the MP2/6‐311G(d,p)//MP2/6‐31G(d) level. It was found that the conformation where the OH group is gauche to the phenyl group is the most stable. The geometry where both the OH and R groups are close to phenyl is the second most stable. This finding has been interpreted on the grounds of the attractive OH/π and CH/π hydrogen bonds and a repulsive van der Waals interaction between vicinal CH groups. NMR nuclear Overhauser effects, spin‐coupling data, and IR spectroscopic data are consistent with the conclusion given by the MO calculations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Synthesis of 3′−3′‐Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation
Authors: Amato Jussara , Galeone Aldo , Oliviero Giorgia , Mayol Luciano , Piccialli Gennaro , Varra Michela 
Published: May 2004

AbstractOligonucleotides with a 3′−3′ inversion of polarity, containing an acridine moiety attached to the nucleotide base flanking the 3′−3′ phosphodiester bond, have been synthesised, characterised and used to form alternate‐strand triple helix complexes. These have been investigated by UV melting studies and CD experiments. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
A Radical Roundabout for an Unprecedented Tandem Reaction Including a Homolytic Substitution with a Titanium‐Oxygen Bond
Authors: Gansäuer Andreas , Rinker Björn , Ndene‐Schiffer Noëllie , Pierobon Marianna , Grimme Stefan , Gerenkamp Mareike , Mück‐Lichtenfeld Christian 
Published: May 2004

AbstractConceptually novel homolytic substitutions (SH2) of ClCp2Ti−O bonds with benzylic, secondary and tertiary alkyl radicals are described. The intermediates and crucial transition structures were studied by DFT methods. The resulting atom economical radical tandem reaction can be utilized for the synthesis of structurally complex tetrahydrofurans from simple starting materials and is therefore of interest for natural product synthesis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
2,6‐Bis(pyrazolyl)pyridine Functionalised with Two Nitronylnitroxide and Iminonitroxide Radicals
Authors: Zoppellaro Giorgio , Geies Ahmed , Enkelmann Volker , Baumgarten Martin 
Published: May 2004

AbstractDuring the last two decades, growing interest in the field of material chemistry has been focused on the synthetic design of organic high‐spin molecules for use as novel magnetic materials. Conjugated radicals based on the bis(pyrazolyl)pyridine core are very attractive in principle, since they per se combine optical, chelating and magnetic properties on a single molecular entity. The functionalisation of this core via the bis(4′‐formyl) derivatives with Ullman radicals results in novel functional biradicals, which may further be used for supramolecular architectures. In this paper we describe the synthesis, structure and properties of 2,6‐bis[4′‐(3‐oxo‐1‐oxyl‐4,4,5,5‐tetramethylimidazolin‐2‐yl)pyrazol‐1′‐yl]pyridine (Pz2PyNN) and 2,6‐bis[4‐(1‐oxyl‐4,4,5,5‐tetramethylimidazolin‐2‐yl)pyrazolyl]pyridine (Pz2PyIN). The two biradicals can clearly be differentiated by UV/Vis, IR and EPR spectroscopy. The optical absorptions of the blue Pz2PyNN appear around λmax= 610 nm (ϵ ≈︁ 1700 M−1 cm−1) while for Pz2PyIN the orange‐red colour arises from absorptions at λmax= 468 nm (ϵ ≈︁ 1400 M−1 cm−1). A triplet ground state for the bis(nitronylnitroxide) Pz2PyNN with ΔES‐T ≈︁ 11.8 ± 4.8 cm−1 can be deduced from the EPR studies because of the increase of the double integrated intensity times temperature at very low temperatures, indicating complete population of the triplet state. For the related bis(iminonitroxide) Pz2PyIN a much smaller (at least one order of magnitude lower) singlet−triplet energy gap with an upper limit of 0.7 cm−1 has been derived (0.7 ⪖ ΔES‐T ⪖ −0.07 cm−1). The new multifunctional biradicals represent the first example of high‐spin molecules in the bis(pyrazolyl)pyridine family. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)