bluuebunny/crossref_metadata_2025_split huggingface dataset:
R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation
Authors: Hayase Eiko , Ara Takahide , Saito Yumika , Takahashi Shuichiro , Yoshioka Kosuke , Ohigashi Hiroyuki , Ogasawara Reiki , Yokoyama Emi , Yamakawa Tomohiro , Ebata Ko , Hasegawa Yuta , Tomizuka Kazuma , Teshima Takanori 
Published: December 2023

Abstract
Graft-versus-host disease (GVHD) is the major obstacle to performing allogeneic hematopoietic cell transplantation (allo-HCT). We and others have shown that intestinal stem cells are targeted in lower gastrointestinal GVHD. A leucine-rich repeat–containing G-protein coupled receptor 5 (Lgr5)–expressing gastric stem cells (GSCs) reside at the base of the gastric glands in mice. After experimental allo-HCT, Lgr5+ GSCs significantly decreased. Parietal cells, which underwent continuous renewal by GSCs, were injured in gastric GVHD, leading to failure of gastric acidification and aerobic bacterial overgrowth in the duodenum. Fate-mapping analysis demonstrated that administration of R-Spondin1 (R-Spo1) that binds to Lgr5 for 6 days in naïve mice significantly increased proliferating epithelial cells derived from Lgr5+ GSCs. R-Spo1 administered on days −3 to −1 and from days +1 to +3 of allo-HCT protected GSCs, leading to amelioration of gastric GVHD and restoration of gastric acidification, and suppression of aerobic bacterial overgrowth in the duodenum. In conclusion, Lgr5+ GSCs were targeted by gastric GVHD, resulting in disruption of the gastric homeostasis, whereas R-Spo1 protected Lgr5+ GSCs from GVHD and maintained homeostasis in the stomach.
A novel ADAMTSL4 compound heterozygous mutation in isolated ectopia lentis: a case report and review of the literature
Authors: Wei Hengguang , Meng Xuyun , Qin Huali , Li Xia 
Published: December 2023

Abstract
Background
Congenital ectopia lentis is characterized by dislocation of the lens caused by partial or complete abnormalities in the zonular fibers. It can be caused by either systemic diseases or isolated ocular diseases. Gene detection techniques can provide valuable information when an etiological diagnosis is challenging. Herein, we report the case of a six-year-old girl with a confirmed diagnosis of isolated ectopia lentis caused by a compound heterozygous ADAMTSL4 gene mutation.

Case presentation
The patient was a 6-year-old Chinese Han girl with strabismus in the right eye. Slit lamp examination revealed that the lens in the right eye was opacified and dislocated, without an ectopic pupil. Gene detection demonstrated the presence of a compound heterozygous mutation in the ADAMTSL4 gene [c. 2270dupG (p.Gly758Trpfs *59) and c. 2110A > G (p.Ser704Gly)], and the diagnosis of isolated ectopia lentis was confirmed. She underwent lens extraction, and a sutured scleral-fixated posterior chamber intraocular lens (IOL) was placed in the right eye. The best-corrected visual acuity was 0.1 one month postoperatively.

Conclusion
Gene detection plays a crucial role in diagnosing disorders with similar symptoms, such as isolated ectopia lentis and Marfan syndrome. In this study, we used whole exons sequencing to diagnose isolated ectopia lentis and identified the variant c.2110A > G (p.Ser704Gly), which may be associated with the development of ectopia lentis and early-onset cataract in the patient. These pathogenic gene mutations have significant implications for the genetic diagnosis of congenital ectopia lentis, treatment, surveillance, and hereditary and prenatal counseling for the patient and their family members.
Carbimazole-associated Pancreatitis: Report From Western India
Authors: Shivane Vyankatesh , Mehta Nihar , Jhaveri Ajay , Memon Saba Samad 
Published: December 2023

Abstract
Pancreatitis is a very rare complication of methimazole and carbimazole therapy. We describe a case of possible carbimazole-associated pancreatitis. A 41-year-old Asian man (with no comorbidities) reported to the hospital with atrial fibrillation and a fast ventricular rate. He was diagnosed with hyperthyroidism due to Graves disease. His rhythm was reverted with amiodarone, and carbimazole was initiated at 15 mg daily for the medical management of Graves disease. Fifteen days later, he presented with acute severe abdominal pain and vomiting with elevated serum amylase 387 U/L (reference range, 28-100 U/L) and lipase levels 206 U/L (reference range, 13-60 U/L). Magnetic resonance imaging showed a bulky pancreas with extensive extrapancreatic fat stranding suggestive of acute pancreatitis. Considering the possibility of carbimazole-related pancreatitis, the drug was withheld. He was managed conservatively, and his pancreatic enzymes normalized within 1 week. The observation suggests that the pancreatitis was a consequence of the therapy with carbimazole. Although it is a rare occurrence, patients taking carbimazole who report abdominal discomfort and vomiting should be evaluated for pancreatitis.
Becoming User: Oracle, Barbara Gordon, and Representations of the User in Popular Culture
Authors: Dinnen Zara 
Published: December 2023

Abstract
This essay considers the figure of the “user” as an emergent subject of late twentieth-century US culture, in relation to the World Wide Web and the 1990 Americans with Disabilities Act. The user is a subject position that is historical in the sense that use relations have always determined social formations within capitalism, but it has been newly energized in contemporary modes of capitalism after digital computing, and newly weighted in contemporary renderings of the nation-state as service provider. This essay turns to a cultural moment in which a privatized user subject was coming into formation, using comic books of this moment to find the user figure and its stories. The DC Comics archive might not seem the most likely place to find answers to these concerns. But superhero origin stories are always about becoming user in late capitalist imaginaries. Superheroes learn to use their histories to reproduce the world they want. The then newly inaugurated DC Comics character Oracle, aka Barbara Gordon (formerly Batgirl), is becoming a wheelchair user and a computer user. Reading Oracle's 1990s user origin stories, this essay attends to scenes of wheelchair and computer use to work out a theory of user history and user time emerging in 1990s US culture. The comics reveal that the process of becoming user is always intersecting with the processes of becoming a racialized, gendered, classed, (dis)abled subject. They also open up the possibility for other affordances: becoming user as a process which can be torqued in its unfolding.
The Politics of Apocalypse
Authors: Epstein Mikhail 
Published: December 2023

Abstract
This guest column examines the historical fate of Russia in its catastrophic confrontation with Ukraine and the West. The piece considers the negative self-definitions of Russia that have arisen in the aftermath of the communist utopia and its virtual transformation into an anti-world — a society whose purpose is to undermine and destroy. Emerging Russian cults of war, death, and apocalypticism are stressed, as are the paradoxes and inversions by which Russia, in attempting to become stronger, becomes weaker and indeed suicidal.
Introduction: Telling the Untold Story of Random Political Recruitment
Authors: Dowlen Oliver 
Published: December 2023

Abstract
Introducing part 2 of the Common Knowledge symposium “Antipolitics,” this essay summarizes the “untold story” of the random recruitment of citizens for political office in Western Europe. Although sortition was used extensively in ancient Athens and in late medieval Europe, it is now (except for the randomly selected jury) a largely discontinued practice. While a good deal is known about when and where this procedure was used, there is little surviving documentation of exactly why it was used and of what it was thought to contribute to the political systems in which it was deployed. This untold story, therefore, is not simply about historical instances of use but must also be an analysis and critique of its use. Key points that emerge are that (1) a lottery takes the decision to appoint or elect away from partisan protagonists, so it therefore acts as a mechanism that can break up and disperse power; and (2) a lottery can serve as a trusted mediation or agreement between parties, because the resultant decision is anonymous.
Socrates and Sortition
Authors: Demont Paul 
Published: December 2023

Abstract
In consonance with the view of Aristotle in book 4 of the Politics, Montesquieu wrote that “selection by lot is in the nature of democracy; election by choice is in the nature of aristocracy.” Although the drawing of lots was a marker of classical Athenian democracy, Socrates — according to Xenophon's Memorabilia — was strongly opposed to it as irrational. According to Socrates and Plato, the citizen of a democracy exists in a moral anarchy, and every choice he makes is random, as if drawn by lot, hence the appropriateness of random choice as a principle of Athenian democracy. And yet, despite this negative assessment of the institution, Socrates was willing to participate in a lottery that made him a member of the Council of Five Hundred, the supreme political body of Athens. This essay — a contribution to the Common Knowledge symposium “Antipolitics” — attempts to explain this paradoxical stance, with reference to Plato's allusions to it.
Samuel Butler's Contributions to Biological Philosophy
Authors: Allen Barry 
Published: December 2023

Abstract
Samuel Butler is usually remembered for Erewhon, widely considered among the best English satires. He also contributed to philosophical biology in works that collectively compose the nineteenth century's finest statement of the evolutionary argument associated with the name of Lamarck. In writing on evolution, Butler was not presenting science for a popular audience but deliberately intervening in the scientific argument about Darwinism. Surprised by the success of his first venture in philosophical biology, Life and Habit, Butler committed himself to the project of developing an alternative to Darwinism, which he did in three additional volumes, and these are the works canvassed in this “delayed book review.”
Evaluation Metrics for Augmented Reality in Neurosurgical Preoperative Planning, Surgical Navigation, and Surgical Treatment Guidance: A Systematic Review
Authors: Kos Tessa M. , Colombo Elisa , Bartels L. Wilbert , Robe Pierre A. , van Doormaal Tristan P. C. 
Published: December 2023

BACKGROUND AND OBJECTIVE:
Recent years have shown an advancement in the development of augmented reality (AR) technologies for preoperative visualization, surgical navigation, and intraoperative guidance for neurosurgery. However, proving added value for AR in clinical practice is challenging, partly because of a lack of standardized evaluation metrics. We performed a systematic review to provide an overview of the reported evaluation metrics for AR technologies in neurosurgical practice and to establish a foundation for assessment and comparison of such technologies.

METHODS:
PubMed, Embase, and Cochrane were searched systematically for publications on assessment of AR for cranial neurosurgery on September 22, 2022. The findings were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

RESULTS:
The systematic search yielded 830 publications; 114 were screened full text, and 80 were included for analysis. Among the included studies, 5% dealt with preoperative visualization using AR, with user perception as the most frequently reported metric. The majority (75%) researched AR technology for surgical navigation, with registration accuracy, clinical outcome, and time measurements as the most frequently reported metrics. In addition, 20% studied the use of AR for intraoperative guidance, with registration accuracy, task outcome, and user perception as the most frequently reported metrics.

CONCLUSION:
For quality benchmarking of AR technologies in neurosurgery, evaluation metrics should be specific to the risk profile and clinical objectives of the technology. A key focus should be on using validated questionnaires to assess user perception; ensuring clear and unambiguous reporting of registration accuracy, precision, robustness, and system stability; and accurately measuring task performance in clinical studies. We provided an overview suggesting which evaluation metrics to use per AR application and innovation phase, aiming to improve the assessment of added value of AR for neurosurgical practice and to facilitate the integration in the clinical workflow.
Frame-By-Frame Animation in Teaching Descriptive Geometry
Authors: Paliy N. 
Published: December 2023

The paper presents using of frame-by-frame animation of geometric constructions in the course "Descriptive Geometry" to present educational graphic material in a more accessible and visual form for students.
Electronic support of descriptive geometry classes used at the Department of Engineering Graphics at Bauman Moscow State Technical University made in the technique of frame-by-frame animation in the format of presentations and electronic text publications is presented.
The technique of creating frame-by-frame animation is described. Geometric constructions are performed using computer graphics systems, in layers; each layer contains one step of construction. When layers are showed on alternately, a number of graphic files are created, which are inserted in a certain sequence on presentation slides or on the pages of an electronic text publication. During the demonstration, a visualization of the course of geometric constructions is created on the screen.
Teachers when giving lectures and practical classes use electronic support of classes, made in the format of presentations to demonstrate the course material on the screen in the classroom. The presentations contain graphic material in the technique of frame-by-frame animation and minimal text material; the teacher gives the necessary explanations.
Electronic support of classes, made in the form of an electronic educational visual aid, is used for independent work of students. Unlike classroom presentations, in an electronic educational visual aid, the animation of geometric constructions is accompanied by a text step-by-step description of the sequence of solving geometric problems.
The main advantage of using electronic training software made in frame-by-frame animation technology compared to traditional software is the visibility and the ability to consistently, step by step, understanding the course of graphic constructions, with the ability to go back and repeat the sequence at any stage.
Valuing and sustaining older peoples' day care services
Authors: McDonald Anne , Frazer Kate , Warters Austin 
Published: December 2023

Background: Unprecedented ageing and growth of the global population of older people is predicted. Between independent and residential care, day care is an essential part of a population-based strategy to support ageing well in place. Aims: To describe experiences of older people attending day care services. Method: Using the qualitative method, two focus groups were completed in 2018 in a region of Ireland with 12 participants. Interviews were audio-recorded and transcribed; grounded theory guided the subsequent analysis. Findings: Older people valued their participation in day care, describing the ‘home from home’ experience positively. Community nurses from the local public health nursing service played a key role in fostering and sustaining participation. Conclusions: National commitment to population-based age friendly environments is required to facilitate the wellbeing of a growing older demographic.
Productive interactions in a port city: a proximity approach to coordination in science-policy collaborations
Authors: Smit Jorrit P. , Westerduin Hedi , van Buuren Arwin 
Published: December 2023

Background:
Many different concepts have been invoked in the literature to describe coordination between scientific and policy practices. However, a framework to understand different types of this boundary management is lacking, which allows ‘linear’ models and ‘gap’ metaphors to persist.
Objectives:
To operationalise the multidimensional ‘proximity’ approach from innovation studies in the context of coordination work between science and policy and employ it in a case study of hybrid research spaces in the port city of Rotterdam.
Method:
Semi-structured interviews and focus groups with scientists, policymakers and policy researchers involved in collaborative knowledge labs.
Findings:
Different proximity dimensions can both stimulate and impede productive interactions in collaborations between science and policy actors. There is no uniform mechanism to overcome coordination problems and different knowledge labs use different combinations of proximities.
Discussion and conclusions:
We conclude that the concepts of cognitive, social, organisational and geographic proximity enable a fine-grained articulation of the balancing act required for successful and enduring collaborative knowledge work between scientists and policymakers. The operationalisation of proximity for structured science-policy interactions led us to the insight that an analytical distinction can be made between ordering and operating enactments of proximity. Ultimately, we interpret this as two types of politics of knowledge production, and call on policymakers, researchers, and other involved parties to take this into consideration when organising structural knowledge collaborations between research and policy practices.
Surveillance Outcome and Genetic Findings in Individuals at High Risk of Pancreatic Cancer
Authors: Rosner Guy , Scapa Erez , Ziv Tomer , Gluck Nathan , Ben-Yehoyada Merav 
Published: December 2023

INTRODUCTION:
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate. PDAC surveillance is recommended in high-risk individuals (HRIs) with strong PDAC family history or a pathogenic germline variant (PGV) in a PDAC susceptibility gene. We aimed to explore a potential correlation between genetic status, extent of family history, pancreatic findings, and surveillance implications in heterogeneous PDAC HRIs.

METHODS:
A total of 239 HRIs from 202 families were tested genetically and underwent prospective pancreatic surveillance for 6 years.

RESULTS:
The cohort was divided into 3 groups: familial pancreatic cancer (FPC; 70 individuals, 54 families), familial non-FPC (81 individuals, 73 families), and hereditary pancreatic cancer (PC) (88 individuals, 75 families). PGVs were detected in 37.6% of all families, including 11.1% of FPC families and 9.6% of familial non-FPC families. The hereditary PC group had earlier onset of PDAC compared with the other 2 groups. BRCA2 PGV carriers showed earlier onset of PDAC and pancreatic cysts. Of the 239 HRIs, PDAC was detected in 11 individuals (4.6%), with 73% diagnosed at an early stage; 4 (1.67%) had pancreatic neuroendocrine tumor; 6 (2.5%) had main-duct intraductal papillary neoplasm (IPMN); and 41 (17.15%) had side-branch IPMN. Seventeen individuals were referred to surgery, and 12 were alive at the end of the study.

DISCUSSION:
The percentage of PDAC was similar in the 3 groups studied. The hereditary PC group, and particularly BRCA2 PGV carriers, had an earlier age of PDAC onset. PGVs were detected in a significant percentage of HRIs with PC. Surveillance seems effective for detection of early-stage PDAC and precursor lesions.
BRIDGING CULTURES: INTERCULTURAL COMMUNICATION IN PUBLIC RELATIONS FOR JAKARTA PRACTITIONERS
Authors: Tomohardjo Irmulansati , Ahmad Mokhtarrudin , Amrullah Haekal Fajri 
Published: December 2023

This research aims to describe how public relations practitioners apply intercultural communication competence, who have worked in government institutions, mass media, hospitality, and other organizations with a diversity of ethnic and cultural members, and also should have specific competence to solve their problem communication in all daily activities. This research is based on an intercultural communication perspective, and interpersonal competence of public relations, with the research method being a case study, interviewing technique for gathering data, and qualitative descriptive analysis.Five key informants invited with different background organizations described that they have worked in public relations functions and follow the mechanism of intercultural communication competencies, such as motivation to communicate, sufficient knowledge of culture, appropriate communication skills, sensitivity, and character. The research result describes five competencies that have applied in their professional communication activities, especially building good relationships, mapping cultural background, having a high motivation to communicate with others, practicing relevant communication when they encounter several difficulties, then always trying to understand the psychology of others when they start to communicate, in formal or informal situation. Then, in the process of anticipating so as not to experience frustration or culture shock with communication partners from different cultures, the speakers also made adaptations, making relevant adjustments, based on the current situation, in the form of speaking in general, discussing local products, discussing the latest issues. and optimize social media. It becomes a medium to reduce the inconvenience of communicating due to differences in culture and background.
DISCLOSING BEHIND MOSQUE AND MUSALLA LOUDSPEAKER POLICY REPORT: ANALYSIS OF KOMPAS.COM AND DETIK.COM
Authors: Sultan M Iqbal , Setyo Bono , Rahmadiva Lelita Azaria 
Published: December 2023

Mosques and Musalla Loudspeakers Policy, and the analogy of the azan with barking dogs by the Minister of Religion, Yaqut Cholil Qoumas has drawn pros and cons from various party. The pros and cons are inseparable from the influence of online news media. This study tries to answer questions related to news tendencies and the background of the pros and cons of the Policy Guidelines for Using Loudspeakers in Mosques and Musalla. This study analyzes news related to Mosques and Musalla's loudspeaker Policy on the two most influential online news media in Indonesia based on SEMRUSH, namely Kompas.com, and Detik.com. Content analysis is used for this study, carried out two weeks after the policy was issued, from February 21 to March 6, 2022. The study results found that The informant's affiliation greatly contributes to providing a pro or con statement. News tendency is influenced by who and what interests are behind these two big media. This reporting trend is shown through the appointed Informants, the titles and narratives presented, and the topics of news discussion. The causes of the pros and cons of the Minister of Religion's policy are due to differences in perceptions in interpreting the policies and statements of the Minister of Religion Yaqut Cholil Qoumas by the informants.