bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report
Authors: Yamaguchi Yusei , Takagi Shunsuke , Takahashi Hidehiko , Sugihara Genichi 
Published: January 2024

AbstractBackgroundWe present a case report on the efficacy of the short‐term application of vortioxetine in managing winter depression in patients with seasonal bipolar disorder (BP). Standard treatment strategies for BP may not adequately address seasonal depressive symptoms during winter in patients with seasonal BP patterns. Depressive symptoms during winter may be linked to seasonal changes in serotonin transporter binding, such as a decrease in synaptic serotonin levels, necessitating alternative approaches. Although antidepressants, including vortioxetine, are effective in treating seasonal monopolar depression, their efficacy and safety in treating depression in patients with seasonal BP patterns remain unclear.Case PresentationThis case report focuses on a 44‐year‐old male patient diagnosed with seasonal BP who had recurrent depressive episodes, specifically during winter. Notably, the patient had a significant decrease in recurrent episodes after short‐term seasonal vortioxetine use without inducing mania or rapid cycling.ConclusionOur study highlights the potential effectiveness of a seasonal, short‐term treatment strategy with antidepressants, including vortioxetine, for winter depression in individuals with BP.
Gamma radiation impact on dielectrics and RH sensitivity of nylon–carbon–GNP–epoxy composites
Authors: Shivamurthy Anupama , Boranna Rakshith , Chikkakuntappa Ranganathaiah , Jagannat Raviprasad Kogravalli , R. Prashanth Gurusiddappa 
Published: January 2024

AbstractComposites of carbon–graphene nanoplatelets (GNP) epoxy with nylon‐66 interleaving were fabricated and investigated to understand the impact of γ‐irradiation on their dielectrics and relative humidity (RH) sensitivity by capacitance and water absorption measurements. The moisture sensitivity was investigated by measuring memory effect (hysteresis) and response time of the capacitance. Composites were γ‐irradiated at doses of 1000 and 3000 kGy and studied by the same set of measurements. X‐ray diffraction analysis, Fourier transform infrared spectroscopy, and scanning electron microscopy were used to understand the impact of γ‐irradiation on the morphology and surface roughness of the composites. Results of these measurements suggest that 3000‐kGy dose γ‐irradiation produces good chain scission and cross‐linking, resulting in reduced water absorption and a 360% increase in capacitance values. The sensitivity of capacitance for 3000‐kGy γ‐irradiated composite was found to be highest at 40 pF/%RH, and hysteresis was 1.8% RH and not observed in non‐irradiated composites. Based on these observations, it seems that 3000‐kGy γ‐irradiated composite could be a potential candidate for moisture content diagnostics during condition monitoring of the carbon–epoxy structures in several industrial applications and needs to be further investigated.Highlights
Composites of carbon–GNP epoxy with nylon‐66 interleaving were γ‐irradiated.
3000‐kGy dose γ‐irradiated composites exhibit 360% increase in capacitance.
Sensitivity and hysteresis were higher than those of 1000‐kGy and non‐irradiated samples.
Good chain scission and cross‐linking resulted in reduced water absorption.
A strategy for producing isotopically labeled peptides with antimicrobial activity or with short in vivo lifetime in Escherichia coli
Authors: Ren Qiongqiong , Fan Zejun , Han Rong , Sang Meihui , Ma Changxing , Zhao Xiaoli , Wang Shenlin 
Published: January 2024

AbstractEngineered Escherichia coli (E. coli) strains have been widely used to produce isotopically labeled peptides for NMR characterization on their structures and interactions. However, production of antimicrobial peptides (AMPs) by E. coli is still challenging, because AMPs are toxic to E. coli host and would lead to cell death after induction. On the other hand, expression of short peptides in E. coli host often encounter problems of the short in vivo lifetime of the peptides, which were rapidly degraded by endogenous enzymes during expression and purification steps. This report presents a practical method for overcoming these bottlenecks to enable E. coli to express AMPs and peptides that have short in vivo lifetime. This design uses the fusion of thioredoxin tags at both the N‐ and C‐termini of the target peptides. The steric effect of the large soluble tags at both ends of the peptide reduces peptide accessibility, thereby enhancing their in vivo stability and eliminating the toxicity associated with AMPs. The approach was validated using an AMP A3K/L7K‐LAH4 (K3K7) and a membrane fusion peptide (FP), which is a segment of the spike protein of SARS‐CoV‐2 and functions in fusing viral membranes and host cell membranes. Fusion expression of K3K7 with a thioredoxin tag only at the N‐terminal resulted in high toxicity to the host cells, leading to impaired cell growth and a failure to obtain expressed fusion protein. In contrast, the fusion proteins from both termini were successfully expressed and purified. In the case of the FP, the fusion of thioredoxin at both termini significantly enhanced its stability, protecting it from enzymatic degradation during expression and purification steps. On the contrary, the FP with thioredoxin fused only at the N‐terminal was found to be unstable in E. coli host strains. As stable isotope labeling on peptide is essentially important in NMR‐based structure and interaction studies, we also demonstrated that the developed approach enables efficient 15N labeling for NMR studies. This strategy may also be extended to produce other challenging peptides.
Engineering of bioorthogonal polyzymes through polymer sidechain design
Authors: Hirschbiegel Cristina‐Maria , Goswami Ritabrita , Chakraborty Soham , Noonan Cedar , Pham Edward , Nagaraj Harini , Ndugire William , Fedeli Stefano , Rotello Vincent M. 
Published: January 2024

AbstractSynthetic polymer scaffolds can encapsulate transition metal catalysts (TMCs) to provide bioorthogonal nanocatalysts. These “polyzymes” catalyze the in situ generation of therapeutic agents without disrupting native biological processes. The design and modification of polymer scaffolds in these polyzymes can enhance the catalytic performance of TMCs in biological environments. In this study, we explore the hydrophobic design space of an oxanorborneneimide‐based polymer by varying the length of its carbon side chain to engineer bioorthogonal polyzymes. Activity studies indicate that modulating the hydrophobicity of the polymer scaffold can be used to enhance the catalyst loading efficacy, catalytic activity, and serum stability of polyzymes. These findings provide insight into the structural elements contributing to improving polymeric nanocatalysts for a variety of applications.
Examining the impact of androgen deprivation therapy, masculine self‐esteem, and psychological flexibility on distress and quality of life in men with prostate cancer
Authors: Chowdhury Emil , Horrocks Thomas , McAteer Gareth , Gillanders David 
Published: January 2024

AbstractObjectiveStudies suggest that androgen deprivation therapy (ADT) exacerbates psychological and quality of life (QoL) issues associated with prostate cancer (PCa). However, quantitative research examining underlying psychosocial mechanisms for this is limited. We examined the association of PCa symptoms with distress and QoL in ADT‐treated and ADT‐naïve patients, and the influence of masculine self‐esteem and psychological flexibility (PF) on these relationships.MethodsSecondary analysis of a quantitative, cross‐sectional survey of 286 PCa patients. Independent samples t‐tests, moderation, and conditional process analysis were used to assess relationships between predictor, mediator, moderator, and outcome variables.ResultsADT was associated with greater PCa symptomology, lower masculine self‐esteem, and lower QoL. Moderation analysis showed that ADT potentiated adverse impacts of PCa symptomology on distress and QoL. High PF attenuated these relationships, though less so for ADT‐treated participants. Conditional process analysis showed that masculine self‐esteem mediated the predictive effect of symptoms on distress across treatments. However, ADT did not moderate this indirect effect, nor was moderation conditional on PF.ConclusionPF appears to: (1) attenuate psychological distress in ADT patients; and (2) improve distress, QoL, and masculine self‐esteem in ADT‐naïve patients. Interventions targeting PF may thus be a viable adjunct to established approaches. However, their effects may be comparatively limited in ADT patients, who may benefit from more intensive and tailored treatment.
Damage mitigation method studies through simulation modeling of chemical accidents
Authors: Oh Sehyeon , Lee Junseo , Ma Byungchol 
Published: January 2024

AbstractIn the chemical industry, when a fire occurs, a significant amount of energy is generated due to combustion, impacting other facilities within the plant and potentially leading to severe consequences through a domino effect. For decades, thermal radiation caused by flames has been calculated and predicted through simplified fire modeling. However, with advancements in computing technology, numerical model‐based calculations have greatly improved, allowing for a more realistic implementation that considers actual phenomena. In this study, accident data and 3D modeling information were utilized to conduct fire modeling and simulation based on actual incidents in chemical plants. Through the analysis of simulation results, the initial emergency evacuation distance was provided to minimize the damage caused by thermal radiation, and the final evacuation distance was presented using the probit function. In addition, the study evaluated the impact of generated thermal radiation and overpressure on structures and equipment, providing evidence regarding the potential for secondary incidents. Moreover, the research revealed that the impact of thermal radiation and overpressure decreases due to obstacles, offering insights into the selection of emergency evacuation routes. This study can contribute to supporting effective emergency evacuation strategies in chemical facilities.
Controlled Cyclic and Bidirectional Hybrid Quantum Communication of Arbitrary Two‐Qubit States
Authors: Gong Li , Chen Xiubo , Xu Gang , Li Zongpeng 
Published: January 2024

AbstractHybrid quantum communication with the combination of quantum teleportation and remote preparation is hopeful for promoting the development of quantum networks and enriching the diversity of quantum network communication. To improve the communication efficiency and enhance the scalability of the quantum networks, a meaningful protocol for controlled cyclic and bidirectional hybrid quantum communication of arbitrary two‐qubit states is proposed, which allows quantum information to be transmitted simultaneously in both directions among multiple participants. With the permission of one controller, each observer can simultaneously transmit arbitrary known two‐qubit states and unknown ones to their adjacent observers, by implementing remote preparation and quantum teleportation in the clockwise and counterclockwise directions. Furthermore, the participants just carry out some quantum measurements and recovery operations to achieve the communication target, and the desired states can be attained with a unit success probability, thus the protocol is deterministic. Finally, some comparisons are also made with other similar protocols, which shows that the protocol is better in qubit efficiency and communication capacity.
Optimal denial‐of‐service attack scheduling for remote state estimation with time‐varying interference power
Authors: Yang Xinxin , Ni Yuqing , Wu Zhe , Yang Wen , Liu Fei 
Published: January 2024

AbstractThis article examines resource scheduling optimization for cyber‐physical systems that include a smart sensor, a remote estimator, and an attacker. The attacker's objective is to use denial‐of‐service (DoS) attack to jam the wireless channel, causing packet loss and reducing system performance. We consider a more realistic scenario where other interfering sources exist and conduct research based on the signal‐to‐interference‐plus‐noise ratio (SINR) model. Through this model, we investigate two cases: constant high or low interference power and time‐varying interference power. Different levels of attack power lead to varying packet loss rates, and the same attack power may result in different packet loss rates in different interference environments. Therefore, the attacker needs to consider the impact of other interferences to find the optimal attack strategy that increases the estimation error of the information‐physical system while reducing energy consumption. We describe this optimization problem in a Markov decision process (MDP) framework and demonstrate the existence of an optimal deterministic Markovian strategy. We also establish the monotonicity of the optimal strategy in two different cases and investigate the extreme case. Simulation results support our theoretical results.
Cycles with many chords
Authors: Draganić Nemanja , Methuku Abhishek , Munhá Correia David , Sudakov Benny 
Published: January 2024

AbstractHow many edges in an ‐vertex graph will force the existence of a cycle with as many chords as it has vertices? Almost 30 years ago, Chen, Erdős and Staton considered this question and showed that any ‐vertex graph with edges contains such a cycle. We significantly improve this old bound by showing that edges are enough to guarantee the existence of such a cycle. Our proof exploits a delicate interplay between certain properties of random walks in almost regular expanders. We argue that while the probability that a random walk of certain length in an almost regular expander is self‐avoiding is very small, one can still guarantee that it spans many edges (and that it can be closed into a cycle) with large enough probability to ensure that these two events happen simultaneously.
Economic policy uncertainty and carbon neutrality in China: Do sustainable energy and eco‐innovation make a difference?
Authors: Song Xiaowei , Irfan Muhammad , Alnafrah Ibrahim , Hao Yu 
Published: January 2024

AbstractSimilar to many other developing and developed countries, China grapples with the challenge of balancing economic growth and environmental preservation. This study, anchored in Sustainable Development Goals (SDGs) 7, 11, 12, and 13, investigates the impact of eco‐innovation and sustainable energy on CO2 emissions (CE) in China from 1980 to 2020, using the STIRPAT model. Employing the autoregressive distributed lag (ARDL) model with bootstrap rolling window causality analysis, we uncover causal relationships between CE and its determinants, assessing them in sub‐sample periods. ARDL estimates reveal that economic policy uncertainty, economic growth, and urbanization increase CE, while eco‐innovation and sustainable energy decrease it. Time‐varying causality analysis demonstrates predictive capabilities of all independent variables at various sub‐periods. The study recommends substantial increases in subsidies and tax incentives for renewable energy, emphasizing stable ecological policies, irrespective of economic conditions, for lasting benefits.
Development and validation of a sustainable education scale
Authors: Çam‐Tosun Figen , Söğüt Sibel 
Published: January 2024

AbstractThis study introduces the Sustainable Education Scale (SES), a novel instrument designed to elicit teachers' perspectives on sustainable education. Grounded in human rights education, sustainable development, social justice, and psychometrics, this survey model‐driven study systematically develops and validates the SES. Drawing on an in‐depth literature review, expert opinions, and pilot testing, the SES comprises 19 items across four sub‐dimensions: Equality in Education, Inclusiveness in Education, Quality in Education, and Democratic Education. Designing a survey based on the quantitative research model, the data was gathered from 573 participating teachers via the criterion sampling method. Demographic analysis indicates that 65.09% of the participating teachers are female (n = 373), while 3.90% are male (n = 200), and most of them have undergraduate degrees with 21 years or more of teaching experience. Construct validity and factor structure were identified through exploratory factor analysis with 273 teacher responses, whereas the validation of the identified structure was performed through CFA from a sample of 300 teachers. Cronbach's alpha and composite reliability coefficient were calculated to ensure the reliability of the scale. The SES scale emerged as valid and reliable data to reveal teachers' perspectives on sustainable education. It stands as an innovative tool for researchers, policymakers, and educators to examine, promote, and advance global goals for inclusive, equitable, and quality learning.
Chlorinephenyl‐Substituted Sulfonylurea Confer Inhibitory Efficacy against Metallo‐β‐lactamase ImiS
Authors: Chen Wei‐Ya , Wu Xiao‐Rong , Zhai Le , Wang Yi‐Xue , Yang Ke‐Wu 
Published: January 2024

AbstractSuper bacterial infection caused by metallo‐β‐lactamases (MβLs) has posed a serious public health threat, while developing inhibitors of MβLs is an ideal strategy to combat drug‐resistance. Here, seventeen sulfonylureas were synthesized and confirmed. Biological assay shown that these molecules effectively inhibited MβL ImiS, with an IC50 value in the range of 29.5–188.2 μM, and the best inhibitor competitively and irreversibly inhibited ImiS with a Ki value of 15.2 μM. Structure‐activity relationship analysis revealed that the chlorine‐substituted phenyl significantly raised inhibitory activity of sulfonylureas on ImiS. Antibacterial and chessboard dilution assays shown that the most sulfonylureas tested enhanced antimicrobial effect of meropenem (MER) on E. coli‐ImiS, and the two inhibitors with best effect resulted in an 8‐fold reduction in MIC of MER. Mice tests shown that the best inhibitor synergizing MER virtually diminished the load of E. coli‐ImiS in spleen and liver. Docking study revealed that the sulfonylurea reacts with ImiS mainly through the sulfonyl group, in which one of oxygen atoms coordinates to Zn(II), and forms two hydrogen bonds with Lys224 (2.1 Å) and His263 (3.1 Å). This work revealed the sulfonylureas are promising candidates for the development of ImiS inhibitors.
Improved Synthetic Methodology, Substrate Scope and X‐ray Crystal Structure for N, N’‐disubstituted Guanidines
Authors: Elumalai Vijayaragavan , Vaclav Eigner , Visnes Torkild , Sundby Eirik , Hoff Bård Helge 
Published: January 2024

AbstractGuanidine is a privileged scaffold in drug discovery. Herein we report our investigations into the acid promoted amination of pyrimidine‐bearing cyanamide to produce N, N’‐disubstituted guanidines. Hydrochloric acid was found to be a suitable catalyst, and the substrate scope using conventional heating was investigated with 23 aniline derivatives. The highest yield was obtained with anilines having pKa in the range of 2–4. Further, a microwave synthesis was developed using 3‐chloroaniline as a model substrate increasing the yield from 68 to 93 %. The microwave method was especially suited for increasing yields with anilines having pKa > 3. The structure of the pyrimidine‐bearing guanidines was confirmed by NMR spectroscopy, and one representative compound has been evaluated by X‐ray crystallography, showing the trans‐isomer as the only tautomer in solid form.
Engineering Innervated Musculoskeletal Tissues for Regenerative Orthopedics and Disease Modeling
Authors: Zhou Zhilong , Liu Jun , Xiong Tiandi , Liu Yuwei , Tuan Rocky S. , Li Zhong Alan 
Published: January 2024

AbstractMusculoskeletal (MSK) disorders significantly burden patients and society, resulting in high healthcare costs and productivity loss. These disorders are the leading cause of physical disability, and their prevalence is expected to increase as sedentary lifestyles become common and the global population of the elderly increases. Proper innervation is critical to maintaining MSK function, and nerve damage or dysfunction underlies various MSK disorders, underscoring the potential of restoring nerve function in MSK disorder treatment. However, most MSK tissue engineering strategies have overlooked the significance of innervation. This review first expounds upon innervation in the MSK system and its importance in maintaining MSK homeostasis and functions. This will be followed by strategies for engineering MSK tissues that induce post‐implantation in situ innervation or are pre‐innervated. Subsequently, research progress in modeling MSK disorders using innervated MSK organoids and organs‐on‐chips (OoCs) is analyzed. Finally, the future development of engineering innervated MSK tissues to treat MSK disorders and recapitulate disease mechanisms is discussed. This review provides valuable insights into the underlying principles, engineering methods, and applications of innervated MSK tissues, paving the way for the development of targeted, efficacious therapies for various MSK conditions.
Ultraviolet Circularly Polarized Luminescence in Chiral Perovskite Nanoplatelet‐Molecular Hybrids: Direct Binding Versus Efficient Triplet Energy Transfer
Authors: Tang Bing , Wei Qi , Wang Shixun , Liu Haochen , Mou Nanli , Liu Qi , Wu Ye , Portniagin Arsenii S. , Kershaw Stephen V. , Gao Xiaoqing , Li Mingjie , Rogach Andrey L. 
Published: January 2024

AbstractThe development of ultraviolet circularly polarized light (UVCPL) sources has the potential to benefit plenty of practical applications but remains a challenge due to limitations in available material systems and a limited understanding of the excited state chirality transfer. Herein, by constructing hybrid structures of the chiral perovskite CsPbBr3 nanoplatelets and organic molecules, excited state chirality transfer is achieved, either via direct binding or triplet energy transfer, leading to efficient UVCPL emission. The underlying photophysical mechanisms of these two scenarios are clarified by comprehensive optical studies. Intriguingly, UVCPL realized via the triple energy transfer, followed by the triplet–triplet annihilation upconversion processes, demonstrates a 50‐fold enhanced dissymmetry factor glum. Furthermore, stereoselective photopolymerization of diacetylene monomer is demonstrated by using such efficient UVCPL. This study provides both novel insights and a practical approach for realizing UVCPL, which can also be extended to other material systems and spectral regions, such as visible and near‐infrared.