bluuebunny/crossref_metadata_2025_split huggingface dataset:
Millimetre and submillimetre spectroscopy of isobutene and its detection in the molecular cloud G+0.693
Authors: Fatima Mariyam , Müller Holger S. P. , Zingsheim Oliver , Lewen Frank , Rivilla Víctor M. , Jiménez-Serra Izaskun , Martín-Pintado Jesús , Schlemmer Stephan 
Published: October 2023

Context. Isobutene ((CH3)2C=CH2) is one of the four isomers of butene (C4H8). Given the detection of propene (CH3CH=CH2) toward TMC-1, and also in the warmer environment of the solar-type protostellar system IRAS 16293–2422, one of the next alkenes, isobutene, is a promising candidate to be searched for in space.
Aims. We aim to extend the limited line lists of the main isotopologue of isobutene from the microwave to the millimetre region in order to obtain a highly precise set of rest frequencies and to facilitate its detection in the interstellar medium.
Methods. We investigated the rotational spectrum of isobutene in the 35–370 GHz range using absorption spectroscopy at room temperature. Quantum-chemical calculations were carried out to evaluate vibrational frequencies.
Results. We determined new or improved spectroscopic parameters for isobutene up to a sixth-order distortion constant. These new results enabled its detection in the G+0.693 molecular cloud for the first time, where propene was also recently found. The propene to isobutene column density ratio was determined to be about 3:1.
Conclusions. The observed spectroscopic parameters for isobutene are sufficiently accurate that calculated transition frequencies should be reliable up to 700 GHz. This will further help in observing this alkene in other, warmer regions of the ISM.
Registrierung startet
Authors: Bechtel Peter 
Published: October 2023

ZusammenfassungDer Gründungsprozess der Pflegekammer Baden-Württemberg ist geschafft, der Vorstand gewählt. Seit September können Pflegefachkräfte registriert werden. Bis März 2024 muss eine Quote von 60 Prozent erreicht sein.
Unterfinanzierung gefährdet Patientenversorgung
Authors: Schaffert Reinhard 
Published: October 2023

ZusammenfassungDie Krankenhausversorgung wird derzeit von knapp 2000 Krankenhäusern sichergestellt. Sie sind jeweils etwa zu einem Drittel in öffentlicher, freigemeinnütziger und privater Trägerschaft. Während die Gesamtkosten der Kliniken stetig steigen, sinken die Investitionsfördermittel durch die Länder. Daraus ergibt sich vielerorts eine dramatische Unterfinanzierung der Kliniken.
The distinctions of the crystallization process of the interphase in polypropylene on untreated and different functional groups-treated CNTs by molecular dynamics simulation
Authors: Qi Yixin , Ju Su 
Published: October 2023

Polypropylene/carbon nanotube composites have attracted much attention for their remarkable electrical and mechanical properties. The key to achieve high performance is good interfacial properties between PP and the CNT. Hence, molecular dynamics simulation, a microscopic and direct method, was used to study the crystallization process of the interphase in a single PP chain on untreated CNT and different functional groups-treated CNT (CNT-OH, CNT-COOH, and CNT-NH2) modes. The simulation showed that the PP chain absorbed and ordered on the CNTs gradually with the increase in simulated time, resulting in regular g(r) and a decrease in the total valence energy, van der Waals energy, and interfacial energy. In particular, in comparison with others, the PP chain on the CNT-OH model had a more orderly g(r) and lower energies after 100 ps, showing a better interfacial interaction in the crystallization process. More specifically, at 2000 ps, the three peaks of the g(r) of the PP chain on the CNT-OH model were 183.78, 129.44, and 95.32, respectively, and the van der Waals and interfacial energies of the PP chain on the CNT-OH model were −167.937 and −869.20 kcal/mol, respectively. It was all attributed to the more orderly crystalline structure, stronger van der Waals forces and stronger phase interactions of the interphase in the PP chain on the CNT-OH model in the crystallization process.
Intelligent forecasting system for rooftop solar plants
Authors: Hegde Vasudha , S Prajwal 
Published: October 2023

The dependency of the off-grid customer on a non-conventional energy sources like solar energy is always not suggested due to the intermittent nature of the power generated. Forecasting the output power helps even the amateur solar roof top consumers to make plan of their self-consumption strategies and also make necessary arrangements for alternate source of energy while minimizing their dependencies on energy storage devices to a great extent. One of the major difficulties faced during the forecasting is procurement of the authentic and accurate digital data since the accuracy of the implemented algorithm depends on many parameters. This work presents a low cost solution for roof top solar plants using intelligent technique. This implemented system has two parts, first one for acquisition and digitization of data with Internet of Things (IoT) and Raspberry Pi and the other part is building a day ahead forecasting model using the deep learning 2D convolution approach with the temporal resolution of 1 h. The data acquisition system collects the power related parameters, such as voltage, current, frequency, active power, and power factor and the related weather parameters, such as temperature, light intensity, and humidity and then appends into Google Sheets using IoT. The error in forecasting the solar power output using these data for 12 months is found to be 11.55%.
Effect of maternal dietary 25OHD3 on the gonadal development of offspring mice
Authors: Chen Yun , Song Wenjing , Liao Danni , Li Jiaxuan , Huang Yanghao 
Published: October 2023

Context Studies have widely reported that a vitamin D3 metabolite 25OHD3 improves the growth performance of animals and offspring, but few studies have focused on offspring sex hormone secretion and gonadal development in the offspring. Aims This study focused on the effects of gestational feeding with 25OHD3 on the growth, serum calcium (Ca2+) and phosphorus (Pi) concentrations, and ovarian and testicular development in offspring. Methods From the beginning of gestation until the end of labour, maternal mice were gavaged daily with 25 ug of 25OHD3. We weighed offspring on Days 1, 10, and 21 postnatally and collected offspring serum and gonadal samples on Day 21. Key results The results showed that 25OHD3 significantly increased maternal serum Ca2+ and Pi concentrations, and increased the growth rate and serum Ca2+ and Pi concentrations of offspring, significantly increased the serum concentrations of luteinising hormone (LH) and follicle-stimulating hormone (FSH), and accelerated the follicle development in the female offspring. Male offspring showed significantly increased LH, FSH, and testosterone serum concentrations, and 3β-HSD and 17β-HSD mRNA expressions, and a significantly decreased CYP17A1 mRNA expression. Conclusions In conclusion, the present findings indicated that maternal feeding with 25OHD3 during pregnancy positively affects offspring hormone secretion and gonadal development. Implications These insights have shed light on the potential significance of maternal nutrition in ensuring healthier animal populations and offer valuable considerations for animal husbandry practices.
Distance decay and directional diffusion of ecoclimate teleconnections driven by regional-scale tree die-off
Authors: Feng Xiao , Swann Abigail L S , Breshears David D , Baldwin Elizabeth , Cheng Haotian , Derbridge Jonathan J , Fei Chengcheng , Lien Aaron M , López-Hoffman Laura , McCarl Bruce , McLaughlin Danielle M , Soto José R 
Published: October 2023

Abstract
Climate change is triggering regional-scale alterations in vegetation including land cover change such as forest die-off. At sufficient magnitudes, land cover change from forest die-off in one region can change not only local climate but also vegetation including agriculture elsewhere via changes in larger scale climate patterns, termed an ‘ecoclimate teleconnection’. Ecoclimate teleconnections can therefore have impacts on vegetative growth in distant regions, but the degrees to which the impact decays with distance or directionally diffuses relative to the initial perturbation are general properties that have not been evaluated. We used the Community Earth system model to study this, examining the implications of tree die-off in 14 major US forested regions. For each case we evaluated the ecological impact across North America as a function of distance and direction from the location of regional tree die-off. We found that the effects on gross primary productivity (GPP) generally decayed linearly with distance, with notable exceptions. Distance from the region of tree die-off alone explained up to ∼30% of the variance in many regions. We also found that the GPP impact was not uniform across directions and that including an additional term to account for direction to regional land cover change from tree die-off was statistically significant for nearly all regions and explained up to ∼40% of the variance in many regions, comparable in magnitude to the influence of El Nino on GPP in the Western US. Our results provide novel insights into the generality of distance decay and directional diffusion of ecoclimate teleconnections, and suggest that it may be hard to identify expected impacts of tree die-off without case-specific simulations. Such patterns of distance decay, directional diffusion, and their exceptions are relevant for cross-regional policy that links forests and other agriculture (e.g. US Department of Agriculture).
Evidence for unexpected net permafrost aggradation driven by local hydrology and climatic triggers
Authors: Sniderhan Anastasia E , Spence Christopher , Kokelj Steven V , Baltzer Jennifer L 
Published: October 2023

Abstract
Rapid rates of high latitude warming over the past century have led to widespread research on permafrost thaw and its consequences. Studies from lowland plains environments in the discontinuous permafrost zone have highlighted extensive areal loss of permafrost, largely through observations of the collapse of forested permafrost plateaus into wetland features. These low-relief environments tend to have poor drainage, which initiates runaway thaw as increased soil moisture amplifies permafrost degradation. In contrast to lowland plains, the Taiga Shield landscape features a network of lakes, wetlands, soil-filled lowlands, and forests interspersed with bedrock outcrops. With the exposed (or near-surface) bedrock in this landscape, this region may have greater terrain stability under a warming climate than the lowland plains. The hydrological complexity of the Taiga Shield may also contribute to more varied trajectories for permafrost in this landscape. We investigated land cover change and implications for permafrost in an area that typifies the Taiga Shield. We took intensive ground-based measurements of soil organic layer (SOL) thickness and frost table depth to characterize different land cover types. Archival aerial photographs and recent satellite imagery from the area allowed us to assess land cover change between 1972 and 2017. Associations between permafrost, SOL, and land cover allowed us to use land cover as a proxy for change in permafrost extent. Our results suggest that both aggradation and degradation of permafrost has occurred within the Taiga Shield landscape over this 45 year period, but interestingly we found evidence for a net increase in permafrost extent. Permafrost aggradation in this landscape seems to be driven by a combination of local hydrology and climatic triggers that lead to colder, drier soil conditions that are favourable for the development of permafrost. This study highlights the importance of considering diverse and heterogenous landscapes in the study of changing permafrost ecosystems.
Effects of L-arginine and arginine-arginine dipeptide on amino acids uptake and αS1-casein synthesis in bovine mammary epithelial cells
Authors: Sun Mei , Cao Yue , Xing Yuanyuan , Mu Xiaojia , Hao Yihong , Yang Jing , Niu Xiaoyu , Li Dabiao 
Published: October 2023

Abstract
Arginine (Arg), as an important functional amino acids (AA), is essential for milk protein synthesis in lactating ruminants. Arg shares transporters with cationic and neutral AA in mammary epithelial cells. Therefore, competitive inhibition might exist among these AA in uptake by mammary epithelial cells. In this study, cultured bovine mammary epithelial cells (BMEC) were used as the model to investigate whether the availability of L-Arg (0.7, 1.4, 2.8, 5.6, and 11.2 mM) affects the uptake of other AA and if this related to αS1-casein synthesis, and whether Arginine-Arginine (Arg-Arg) substituting part of free L-Arg can alleviate competitive inhibition among Arg and other AA, so as to promote αS1-casein synthesis. Our results showed that 2.8 mM L-Arg generated the greatest positive effects on αS1-casein synthesis and the activation of mammalian target of rapamycin (mTOR) signaling pathway (P &lt; 0.01). With L-Arg supply increasing from 0.7 to 11.2 mM, the net-uptake of other AA (except Glu and Ala) decreased linearly and quadratically (Plinear &lt; 0.01; Pquadratic &lt; 0.01). Compared with 2.8 mM, the net-uptake of essential amino acids (EAA) and total amino acids (TAA) were lower at 11.2 mM L-Arg group, while greater at 1.4 mM L-Arg group (P &lt; 0.01). Arg-Arg dipeptide replacing 10% free L-Arg increased αS1-casein synthesis (P &lt; 0.05), net-uptake of EAA and TAA, as well as phosphorylation level of mTOR and p70 ribosomal protein S6 kinase (P70S6K) and mRNA expression of oligopeptide transporter 2 (PepT2; P &lt; 0.01). These observations suggested that the increased αS1-casein synthesis by 10% Arg-Arg dipeptide might be related to the increase of AA availability and the activation of mTOR signaling pathway in BMEC.
Factors Predicting Secondary Respiratory Morbidity Following Early-Life Respiratory Syncytial Virus Infections: Population-Based Cohort Study
Authors: Sarna Mohinder , Gebremedhin Amanuel , Richmond Peter C , Glass Kathryn , Levy Avram , Moore Hannah C 
Published: October 2023

Abstract

Background
The association between early-life respiratory syncytial virus (RSV) infections and later respiratory morbidity is well established. However, there is limited evidence on factors that influence this risk. We examined sociodemographic and perinatal factors associated with later childhood respiratory morbidity requiring secondary care following exposure to a laboratory-confirmed RSV episode in the first 2 years.

Methods
We used a probabilistically linked whole-of-population-based birth cohort including 252 287 children born in Western Australia between 2000 and 2009 with follow-up to the end of 2012. Cox proportional hazards models estimated adjusted hazard ratios (aHRs) of the association of various risk factors with the first respiratory episode for asthma, wheezing, and unspecified acute lower respiratory infection beyond the age of 2 years.

Results
The analytic cohort included 4151 children with a confirmed RSV test before age 2 years. The incidence of subsequent respiratory morbidity following early-life RSV infection decreased with child age at outcome (highest incidence in 2–&lt;4-year-olds: 41.8 per 1000 child-years; 95% CI, 37.5–46.6), increased with age at RSV infection (6–&lt;12-month-olds: 23.6/1000 child-years; 95% CI, 19.9–27.8; 12–&lt;24-month-olds: 22.4/1000 child-years; 95% CI, 18.2–22.7) and decreasing gestational age (50.8/1000 child-years; 95% CI, 33.5–77.2 for children born extremely preterm, &lt;28 weeks gestation). Risk factors included age at first RSV episode (6–&lt;12 months: aHR, 1.42; 95% CI, 1.06–1.90), extreme prematurity (&lt;28 weeks: aHR, 2.22; 95% CI, 1.40–3.53), maternal history of asthma (aHR, 1.33; 95% CI, 1.04–1.70), and low socioeconomic index (aHR, 1.76; 95% CI, 1.03–3.00).

Conclusions
Our results suggest that in addition to preterm and young infants, children aged 12–&lt;24 months could also be potential target groups for RSV prevention to reduce the burden of later respiratory morbidities associated with RSV.
Direction-sensitive dark matter search with 3D-vector-type tracking in NEWAGE
Authors: Shimada Takuya , Higashino Satoshi , Ikeda Tomonori , Nakamura Kiseki , Yakabe Ryota , Hashimoto Takashi , Ishiura Hirohisa , Nakamura Takuma , Nakazawa Miki , Kubota Ryo , Nakayama Ayaka , Ito Hiroshi , Ichimura Koichi , Abe Ko , Kobayashi Kazuyoshi , Tanimori Toru , Kubo Hidetoshi , Takada Atsushi , Sekiya Hiroyuki , Takeda Atsushi , Miuchi Kentaro 
Published: October 2023

Abstract
NEWAGE is a direction-sensitive dark matter search experiment with a 3D tracking detector based on a gaseous micro time projection chamber. A direction-sensitive dark matter search was carried out at Kamioka Observatory with a total live time of 318.0 days resulting in an exposure of 3.18 kg·days. A new gamma-ray rejection and a head–tail determination analysis were implemented for this work. No significant non-isotropic signal from the directional analysis was found and a 90% confidence level upper limit on a spin-dependent weakly interactive massive particle (WIMP)–proton cross section of 25.7 pb for a WIMP mass of 150 GeV/c2 was derived. This analysis marks the most stringent upper limit in the direction-sensitive dark matter searches.
Toxicity assessment and DNA repair kinetics in HEK293 cells exposed to environmentally relevant concentrations of Glyphosate (Roundup® Control Max)
Authors: Roma Dardo , Cecchini Maria Eugenia , Tonini María Paula , Capella Virginia , Aiassa Delia , Rodriguez Nancy , Mañas Fernando 
Published: October 2023

Abstract
Glyphosate is a systemic, non-selective, pre and post-emergence wide range herbicide. In 2015, IARC classified Glyphosate as “a probable carcinogenic agent for humans”. The aim of this study was to evaluate the cytotoxicity and genotoxicity of the commercial formulation of glyphosate (Roundup® Control Max) at environmentally relevant concentrations and measure the potential effect of this herbicide over the cell capacity to repair DNA damage. HEK293 cells were exposed to 5 concentrations of Roundup® Control Max equivalent to 0.7; 7; 70; 700 and 3,500 μg/L glyphosate acid, for 1, 4 and 24 h. Cytotoxicity was quantified by the Trypan Blue staining method and by the MTT assay, while genotoxicity and evaluation of DNA damage repair kinetics were analyzed through the alkaline comet assay. In all treatments, cell viability was higher than 80%. The three highest glyphosate concentrations—70 μg/L, 700 μg/L, and 3,500 μg/L—increased levels of DNA damage compared to the control at the three exposure times tested. Finally, concerning the kinetics of DNA damage repair, cells initially exposed to 3,500 μg/L of glyphosate for 24 h were unable to repair the breaks in DNA strands even after 4 h of incubation in culture medium. The present study demonstrated for the first time that Roundup® Control Max may induce genetic damage and cause alterations in the DNA repair system in human embryonic kidney cells even at concentrations found in blood and breast milk of people exposed through residues of the herbicide in food, which values have been poorly assessed or not studied yet according to the existent literature.
Critical Review—A Tribute to Louis Brocq Lymphomatoid Papulosis, the Key in Exploring the Relationship of Parapsoriasis and Mycosis Fungoides
Authors: Kossard Steven 
Published: October 2023

Abstract:
Both parapsoriasis and LyP appear clinically as inflammatory dermatoses with a paradoxical link to cMF. A key element in addressing the relationship of parapsoriasis and MF were the results of the French and Dutch long-term registries tracking the emergence of lymphomas in the setting of LyP. Both cMF and cALCL emerged almost equally in these long-term studies. This ultimately supports that the stem cells in both cMF and cALCL are probably derived from a common stem cell shared by CD4+/CD8+ memory stem cells defining cMF and CD30+ stem cells defining cALCL. The discovery of inducible Skin Associated Lymphoid Tissue (iSALT) mesenchymal hubs incorporating Tregs, with their pleiotropic functions represents a paradigm shift and formed a translational tool in this analysis of the paradox. LyP can be recast as activated inhibitory lymphomatoid T-cell hubs derived from inducible iTregs in iSALT and the source of the common stem cell LyP line. iSALT Treg integrated mesenchymal hubs provided an emerging translational tool in redefining integrated lymphomatoid pathways. Brocq’s complex scheme defining parapsoriasis as hybrid inflammatory dermatoses with a paradoxical link to cMF became a template to preserve parapsoriasis as a clinical diagnosis. Two major iSALT Treg generated inhibitory integrated lymphomatoid hubs emerged. The major CD30+TNF lymphomatoid hub has been linked to cALCL. Clinically defined chronic regressing and relapsing parapsoriasis with the histopathology of patch stage MF can be redefined as lymphomatoid parapsoriasis. This twin inhibited oncogenic memory based hub is defined by Treg modulated, CD4+/CD8+memory linked PD-1/DL-1 cytoxic complex and lichenoid histopathology.
Interactions of Metformin and Other Medications in Reducing the Odds of Age-Related Macular Degeneration in a Diabetic Cohort
Authors: Shaw Lincoln , Khanna Saira , Hyman Max J , Ham Sandra , Blitzer Andrea , Parvar Seyedeh P , Soo Jackie , Flores Andrea , Hariprasad Seenu , Skondra Dimitra 
Published: October 2023

Abstract

Purpose:
A prior study from our group demonstrated protective effects of the use of metformin in the odds of developing age-related macular degeneration (AMD). This is a subgroup analysis in a diabetic cohort to assess the interaction of metformin and other medications in protecting diabetic patients against developing AMD.

Methods:
This is a case-control analysis using data from the MerativeTM MarketScan® Commercial and Medicare Databases. Patients were aged 55 years and over with newly diagnosed AMD and matched to controls. We performed multivariable conditional logistic regressions which adjusted for known risk factors for AMD and tested multiple interaction effects between metformin and (1) insulin, (2) sulfonylureas, (3) glitazones, (4) meglitinides, and (5) statins.

Results:
We identified 81,262 diabetic cases and 79,497 diabetic controls. Metformin, insulin, and sulfonylureas demonstrated independent protective effects against AMD development. Sulfonylureas in combination with metformin demonstrated further decreased odds of AMD development compared to metformin alone. The other medication group (exenatide, sitagliptin, and pramlintide) slightly increased the odds of developing AMD when taken alone but the combination with metformin alleviated this effect.

Conclusion:
We believe our results bring us one step closer to finding an optimal effective hypoglycemic regimen that also protects against AMD development in diabetic patients.