bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimated glomerular filtration rate in observational and interventional studies in chronic kidney disease
Authors: Provenzano Michele , Hu Lilio , Abenavoli Chiara , Cianciolo Giuseppe , Coppolino Giuseppe , De Nicola Luca , La Manna Gaetano , Comai Giorgia , Baraldi Olga 
Published: February 2024

AbstractEstimated glomerular filtration rate is considered the principal measure of kidney function and, together with albuminuria, is a relevant prognostic factor for the development of end-stage kidney disease. Due to the strong association between estimated glomerular filtration rate and clinical events, such as commencement of dialysis, cardiovascular outcomes and all-cause death, estimated glomerular filtration rate is crucial for clinical decision-making in terms of scheduling follow-up and pharmacological interventions, and planning renal replacement therapies in advanced chronic kidney disease. In this review we discuss the available methods for measuring glomerular filtration rate and for estimating it through mathematical equations developed over the last few decades. We summarize the prognostic association of different percentages of estimated glomerular filtration rate decline and the main clinical outcomes, and how treatments modify estimated glomerular filtration rate decline and the risk of future endpoints. We also examine the role of pre-clinical trial slope and that of estimated glomerular filtration rate as a useful biomarker when evaluating patients for inclusion into both observational and interventional studies.
“Frequently Asked Questions” About Genetic Engineering in Farm Animals: A Frame Analysis
Authors: Koralesky Katherine E. , Tworek Heidi J. S. , von Keyserlingk Marina A. G. , Weary Daniel M. 
Published: February 2024

AbstractCalls for public engagement on emerging agricultural technologies, including genetic engineering of farm animals, have resulted in the development of information that people can interact and engage with online, including “Frequently Asked Questions” (FAQs) developed by organizations seeking to inform or influence the debate. We conducted a frame analysis of FAQs webpages about genetic engineering of farm animals developed by different organizations to describe how questions and answers are presented. We categorized FAQs as having a regulatory frame (emphasizing or challenging the adequacy of regulations), an efficiency frame (emphasizing precision and benefits), a risks and uncertainty frame (emphasizing unknown outcomes), an animal welfare frame (emphasizing benefits for animals) or an animal dignity frame (considering the inherent value of animals). Animals were often featured as the object of regulations in FAQs, and questions about animals were linked to animal welfare regulations. The public were represented using a variety of terms (public, consumer) and pronouns (I, we). Some FAQs described differences between technology terms (gene editing, genetic modification) and categorized technologies as either well-established or novel. This framing of the technology may not respond to actual public concerns on the topic. Organizations seeking to use FAQs as a public engagement tool might consider including multiple viewpoints and actual questions people have about genetic engineering.
Gd2O3/CdS Nanocomposites were Synthesized for Photocatalytic Elimination of Methyl Blue (MB) Dye Under Visible Light Irradiation
Authors: Abdrabou Dalia , Ahmed Mohamed Khalaf , Khairy Sherif A. , El-Sherbini Tharwat Mahmoud 
Published: February 2024

AbstractWater contamination with hazardous dyes is a serious environmental issue that concerns humanity. A green technology to resolve this issue is the use of highly efficient photocatalysts under visible light to degrade these organic molecules. Adding composite and modifying shape and size on semiconductor materials are attempts to improve the efficacy of these compositions. The optical, microstructural and photocatalytic features of the compositions were investigated by several characterization procedures such as XRD, XPS, SEM, and TEM. Here, modifies Scherrer equation, Williamson–Hall (W–H), and Halder–Wagner method (H–W) have been used to investigate the crystal size and the micro-strain from the XRD peak broadening analysis. The average crystal size according to Modified Scherrer’s formula was 6.04–10.46 nm for pristine CdS and CdS/Gd2O3@GO, respectively. While the micro-strain (ɛ) corresponds to 3.88, 4.63, 4.03, and 4.15 for CdS, Gd2O3, CdS/Gd2O3, and CdS/Gd2O3@GO. It was also shown that the modest difference in average crystal size acquired by the Modified Scherrer and Halder–Wagner (HW) forms was related to differences in average particle size classification. As a result, the Halder–Wagner method was accurate in estimating crystallite size for the compositions. The average roughness is slightly changed from 4.4 to 4.24 nm for CdS/Gd2O3 and CdS/Gd2O3@GO, respectively. A kinetics investigation further revealed that the photocatalytic degradation of MB dyes was accompanied by a Langmuir isotherm and a pseudo-second-order reaction rate. The highest adsorption capacity (qe) determined for (type 1) CdS, Gd2O3, CdS/Gd2O3, and CdS/Gd2O3@GO adsorption was 5, 0.067, 0.027, and 0.012 mgg−1, respectively. The R2 values originated from the pseudo-second-order (type 2) for CdS, Gd2O3, CdS/Gd2O3, and CdS/ Gd2O3@GO were 0.904, 0,928, 0.825, and 0.977. As a result, the initial sorption rate (h) is altered between types 1 and 2. In type 2, the pseudo-second-order rate constant (k2) ranges from 0.005 for CdS to 0.011 for CdS/Gd2O3@GO. The Langmuir Hinshelwood and pseudo-second-order kinetic models describe the photodegradation process. The results demonstrate that the developed compositions can be used as a long-term substance for dye removal.
Numerical Analysis on the Static Performance of Gas Journal Bearing by Using Finite Element Method
Authors: Wang Pengfeng , Li Yuntang , Gao Xiang , Ye Yueliang , Li Ruirui , Li Xiaolu , Chen Yuan , Jin Jie , Zhang Cong 
Published: February 2024

AbstractIn this paper, finite element method is used to calculate the static performance of gas journal bearing, in which rotation speed term is introduced into the stiffness matrix of linear triangular element to realize the performance calculation of the bearing with rotation speed. The results indicate that the average gas film thicknesses corresponding to the maximum load capacity and stiffness, and the minimum attitude angle increase with the growth of orifice diameter. Load capacity and stiffness significantly improved with the increase of rotation speed, eccentricity ratio and supply pressure when the bearing has thin average gas film thickness. Attitude angle increases with the growth of rotation speed, while the growth rate slows down or even decreases at high speed. The most effective way of reducing attitude angle is to increase supply pressure. It can be found that rotation speed affects attitude angle through changing gas pressure difference between two orifices, while other parameters have the same effect by changing gas pressure at orifice outlet.
A Decision Tree Based Ultra-high-speed Protection Scheme for Meshed MMC-MTDC Grids with Hybrid Lines
Authors: Gaballah Amr , Abu-Elanien Ahmed E. B. , Megahed Ashraf I. 
Published: February 2024

AbstractThe reliable operation of modular multi-level converter based multi-terminal high voltage direct current (MMC-MTDC) grids requires high-speed and selective DC line protection. A single-ended protection technique is proposed for MTDC grids with offshore wind farms and hybrid lines that involve overhead lines and submarine cables in series. Positive and negative poles’ currents at one end of each line section are analyzed using discrete wavelet analysis (DWA). To classify fault type and identify fault zone, a fine decision tree is supplied with an energy index and the envelope slop of detail 1 coefficient (D1) obtained from DWA. Only 0.2 ms following the fault inception are needed for calculating the energy index and the envelope slope to perform relay functions. The approach was tested on a three-terminal two-poles $$\pm$$
±
400 kV MMC-MTDC model. The simulation results validate the effectiveness of the suggested protection technique under various fault scenarios, even with up to 200 Ω fault resistance. The proposed technique is not only able to detect the faulty line, but also it identifies overhead line faults and submarine cable faults for hybrid type lines. Moreover, the proposed technique is not affected by wind power injection changes, AC faults, or data noise. The simulated model was produced in the MATLAB/Simulink platform.
On Nonlinear Analysis for Multi-term Delay Fractional Differential Equations Under Hilfer Derivative
Authors: Ahmad Dildar , Ali Amjad , Shah Kamal , Abdalla Bahaaeldin , Abdeljawad Thabet 
Published: February 2024

AbstractIn this manuscript, a class of multi-term delay fractional differential equations (FDEs) under the Hilfer derivative is considered. Some newly updated results are established under boundary conditions. For the required results, we utilize the fixed point theory and tools of the nonlinear functional analysis. Further keeping in mind the importance of stability results, we develop some adequate results about the said aspect. The Hyers-Ulam (H-U)-type concept is used to derive the required stability for the solution of the considered problem. Finally, by appropriate test problems, we justify our findings.
Isolation, characterization, and screening of yeast biodiversity for multi- hydrolytic enzymes
Authors: Al Halim Laila R. Abd , Hemeda Nada F. , Serag Ahmed M. 
Published: February 2024

AbstractThe current investigation was conducted with the objective of identifying yeasts that possess the ability to secrete a range of hydrolytic enzymes. Yeast isolates were collected from various samples, and the morphological characteristics of both the colony and yeast cells were examined. The capacity for enzyme production was assessed in multiple isolates by inoculating them in different media and quantifying their activities in terms of pectinase, amylase, urease, lipase, β-galactosidase, and protease. Out of a total of 42 yeast isolates, 30 displayed enzymatic activity. It is plausible that the yeast isolates obtained in this study hold potential for the production of industrial enzymes. Molecular identification techniques were employed to identify two isolates that exhibited multi-enzyme production and the highest enzyme activities. It was determined that these isolates belonged to two genera of yeasts, namely Pichia and Hanseniaspora. Specifically, isolate Y 16 was identified as Pichia kudriavizvii OL621856, while isolate Y 26 was identified as Hanseniaspora guillermondii OL621857 strains.
Hypogammaglobulinemia and Infection Risk in an Ocrelizumab-treated Multiple Sclerosis Cohort
Authors: Nobile Steven , Beauchemin Philippe 
Published: February 2024

ABSTRACT:Background:Ocrelizumab is an effective anti-CD20 therapy approved for Relapsing Remitting (RRMS) and Primary Progressive Multiple Sclerosis (PPMS). In clinical trials, a proportion of patients developed hypogammaglobulinemia which could contribute to infection risk. This study aimed to identify hypogammaglobulinemia and its risk factors and evaluate potentially associated serious infection risk in a real-world cohort of patients.Methods:All MS patients treated with ocrelizumab in a Quebec City MS clinic from January 2017 to August 2021 were included and detailed patient characteristics were collected by chart review. Levels of immunoglobulins (IgM, IgA and IgG) were assessed prior to each treatment. Serious infection was defined as an infection requiring hospitalization or emergency room treatment. Association between hypogammaglobulinemia and serious infection was analyzed.Results:A total of 266 patients (average follow-up 2.05 years) were included (87% RRMS). After 6 infusions, 32.8%, 3.5% and 4.2% of patients had at least one IgM, IgA and IgG hypogammaglobulinemia event respectively. Aside from pre-treatment hypogammaglobulinemia, there were no variables associated with on-treatment hypogammaglobulinemia. There was a total of 21 serious infections (3.36 and 12.33 per 100-person-years in RRMS and PPMS). Developing hypogammaglobulinemia during treatment was not associated with serious infection. A regression analysis did not show associations between serious infection and key disease characteristics.Conclusion:Similar to ocrelizumab extension studies, our cohort demonstrated a significant rate of hypogammaglobulinemia over time, mostly with IgM. No association was found between hypogammaglobulinemia and serious infection.
Underground Empire: Charles Warren, William Simpson, and the Archeological Exploration of Palestine
Authors: Auerbach Jeffrey 
Published: February 2024

AbstractBritish army officer Charles Warren's archeological excavations in Jerusalem in the late 1860s on behalf of the Palestine Exploration Fund and Scottish artist William Simpson's paintings of those activities articulated a new kind of imperial space: the underground empire. The imperial underground was a place that had not yet been conquered and where the British had limited visibility. In contrast to picturesque and panoramic views that created an illusion of order and omniscience, Simpson's sketches depict an imperial presence that was confined, constrained, and in danger of collapse. Yet as the British began to probe this subterranean frontier, they turned the underground world into a place not just of darkness and danger but of exploration and excitement. In the process, Warren's work and Simpson's portrayal of it helped lay the foundation for Britain's eventual conquest of Palestine during the First World War by burrowing beneath Jerusalem's dilapidated Ottoman present in search of its ancient and Judeo-Christian past. Jerusalem was not the only node in Britain's nascent underground empire—British work there occurred alongside the construction of sewers and railway tunnels in London and the mining of gold and diamonds in Australia and South Africa—but it was in Jerusalem that an imperial underground was first and most fully articulated, a space that embodied both the precariousness and the potential of Britain's embryonic efforts to establish a presence in the Middle East.
The Bulgarian connection: the Young Turks in exile and the making of radicalism in Ottoman Europe, 1895–1897
Authors: Öztan Ramazan Hakkı 
Published: February 2024

AbstractFocusing on the years between 1895 and 1897, this article reconstructs what happened after the arrival of Young Turk revolutionaries into the cities of the Danubian hinterland, particularly centering on Rusçuk (Ruse in today’s Bulgaria). In tracing the footsteps of İbrahim Temo and Mustafa Ragıp, two self-exiled figures from İstanbul, this study captures a particular moment when the Danubian cities became the hotbed of transnational radicalism, as a number of assassination plots began to be hatched by Muslim revolutionaries. A well-connected port city serviced by regular steamship links, Rusçuk was where professional revolutionaries met with the local Muslims, much to the ire of Ottoman diplomats in the region. In capturing their encounters, the goal is to point to the significance of Young Turk activities in the Balkans before the turn of the century, a phase which remains understudied in the existing literature. By focusing on a secondary port city that became home to failed assassination plots, this article also seeks to contribute to ongoing discussion in global history that warns against narratives of unhindered globalization. In studying fin-de-siecle radicalization, I hope to contribute to these debates by reflecting upon the limits of globalization as a productive field of historical inquiry.
Association of the short-chain fatty acid levels and dietary quality with type 2 diabetes: a case–control study based on Henan Rural Cohort
Authors: Li Jia , Li Yuqian , Zhang Shuhua , Wang Chongjian , Mao Zhenxing , Huo Wenqian , Yang Tianyu , Li Yan , Xing Wenguo , Li Linlin 
Published: February 2024

Abstract
Evidence of the relationship between fecal short-chain fatty acids (SCFA) levels, dietary quality and type 2 diabetes mellitus (T2DM) in rural populations is limited. Here, we aimed to investigate the association between fecal SCFA levels and T2DM and the combined effects of dietar quality on T2DM in rural China. In total, 100 adults were included in the case–control study. Dietary quality was assessed by the Alternate Healthy Eating Index 2010 (AHEI-2010), and SCFA levels were analysed using the GC-MS system. Generalised linear regression was conducted to calculate the OR and 95 % CI to evaluate the effect of SCFA level and dietary quality on the risk of T2DM. Finally, an interaction was used to study the combined effect of SCFA levels and AHEI-2010 scores on T2DM. T2DM participants had lower levels of acetic and butyric acid. Generalised linear regression analysis revealed that the OR (95 % CI) of the highest acetic and butyric acid levels were 0·099 (0·022, 0·441) and 0·210 (0·057, 0·774), respectively, compared with the subjects with the lowest tertile of level. We also observed a significantly lower risk of T2DM with acetic acid levels > 1330·106 μg/g or butyric acid levels > 585·031 μg/g. Moreover, the risks of higher acetic and butyric acid levels of T2DM were 0·007 (95 % CI: 0·001, 0·148), 0·005 (95 % CI: 0·001, 0·120) compared with participants with lower AHEI-2010 scores (all P < 0·05). Acetate and butyrate levels may be important modifiable beneficial factors affecting T2DM in rural China. Improving dietary quality for body metabolism balance should be encouraged to promote good health.
Reflections on Constitutionalism and Democratic Governance in Africa
Authors: Udombana Nsongurua 
Published: February 2024

AbstractSeveral post-independence African states have opted for constitutional democracies in response to various governance challenges. Most of these constitutions espouse values of constitutionalism, such as the rule of law, human rights and citizenship. This article interrogates the concept of constitutionalism, examines its pillars and values, and reflects on how Africa's constitutions mirror them. Its thesis is that a constitutional government does not necessarily approximate constitutionalism. The article argues, with evidence, that many states possess constitutions but fall short in practising constitutionalism. It calls on these states to embark on institutional reforms and to pursue good governance that improves the living standards of their citizens.
Retail Trading and Return Predictability in China
Authors: Jones Charles M. , Shi Donghui , Zhang Xiaoyan , Zhang Xinran 
Published: February 2024

Abstract
Using comprehensive account-level data, we separate Chinese retail investors into 5 groups and document strong heterogeneity in trading dynamics and performances. Retail investors with smaller account sizes cannot predict future returns correctly, display daily momentum patterns, fail to process public news, and show overconfidence and gambling preferences, while retail investors with larger account balances predict future returns correctly, display contrarian patterns, and incorporate public news in trading. Using performance measures established in previous literature, we find that smaller retail investors suffer from poor stock selection abilities and trading costs, while large retail investors’ stock selection abilities are offset by trading costs.
Disinfection of flexible fibre-optic endoscopes out-of-hours: confidential telephone survey of ENT units in England – 20 years on
Authors: Clymo Jonathon , Bickerton Robert , McBrinn Sarah , Rollin Matthew 
Published: February 2024

AbstractBackgroundFlexible upper aerodigestive endoscopy is often performed in the emergency setting. To prevent nosocomial infection on-call clinicians must have access to decontaminated endoscopes.MethodsA telephone survey of 104 ENT units in England replicated previous cycles conducted 10 and 20 years ago. The on-call clinician was asked about decontamination practices, training and cross-cover.ResultsSeventy-one clinicians participated of which 68 had an endoscope available out-of-hours. Twenty-five (36.8 per cent) used single-use endoscopes. Twenty-three (51.1 per cent) of the 45 clinicians using re-usable endoscopes decontaminated them themselves, an increase from 43.3 per cent in 2013 and from 35.1 per cent in 2002. Overall 91.2 per cent had safe practices, up from 68.7 per cent in 2013 and 48 per cent in 2002. One hundred per cent had been trained in decontamination, compared to 37.3 per cent in 2013 and 12.1 per cent in 2002. On-call clinicians from the ENT department increased to 91.5 per cent, compared to 63 per cent in 2013.ConclusionThere has been a dramatic increase in patient safety, underpinned by the introduction of single-use endoscopes, increased training and reduced cross-cover.
Unveiling the wasp-waist structure of the Falkland shelf ecosystem: the role of Doryteuthis gahi as a keystone species and its trophic influences
Authors: Büring Tobias , van Der Grient Jesse , Pierce Graham , Bustamante Paco , Scotti Marco , Jones Jessica B. , Rocha Francisco , Arkhipkin Alexander 
Published: February 2024

Abstract
The Falkland Shelf is a highly productive ecosystem in the Southwest Atlantic Ocean. It is characterized by upwelling oceanographic dynamics and displays a wasp-waist structure, with few intermediate trophic-level species and many top predators that migrate on the shelf for feeding. One of these resident intermediate trophic-level species, the Patagonian longfin-squid Doryteuthis gahi, is abundant and plays an important role in the ecosystem. We used two methods to estimate the trophic structure of the Falkland Shelf food web, focusing on the trophic niche of D. gahi and its impacts on other species and functional groups to highlight the importance of D. gahi in the ecosystem. First, stable isotope measurements served to calculate trophic levels based on an established nitrogen baseline. Second, an Ecopath model was built to corroborate trophic levels derived from stable isotopes and inform about trophic interactions of D. gahi with other functional groups. The results of both methods placed D. gahi in the centre of the ecosystem with a trophic level of ~ 3. The Ecopath model predicted high impacts and therefore a high keystoneness for both seasonal cohorts of D. gahi. Our results show that the Falkland Shelf is not only controlled by species feeding at the top and the bottom of the trophic chain. The importance of species feeding at the third trophic level (e.g. D. gahi and Patagonotothen ramsayi) and observed architecture of energy flows confirm the ecosystem's wasp-waist structure with middle-out control mechanisms at play.