bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial and attribute filtering as a complementary measure in the statistical prediction of tropical cyclone rainfall
Authors: Hokson Jose Angelo , Kanae Shinjiro 
Published: November 2023

AbstractThe increasing rate of tropical cyclone (TC) rainfall has put populations in the Western North Pacific Region at greater risk of TC rainfall‐induced disasters. Statistical methodologies have shown potential in complementing existing prediction approaches. With TC track prediction accuracy significantly improving, statistical predictions have turned to TC tracks as a measure of similarity between TCs. Several studies have utilized Fuzzy C Means (FCM) to this end. However, FCM alone does not provide guidance on how many similar TCs should be used for predicting rainfall through ensemble averaging. While various number of ensemble members have been used to check the average error, such an approach yields only one number, which may not always be the most appropriate. In this study, we proposed a spatial and attribute filter to complement FCM identification of similar TCs. This filter excludes similar TCs with central pressure differences greater than 5% at strategic TC locations near land. The use of the filter yielded better rainfall prediction values than using FCM alone, as demonstrated in this study and validated against previous research findings. Our proposed model offers a reliable means of predicting TC rainfall when used in conjunction with accurately predicted TC tracks, representing a valuable complementary approach to existing prediction methods.
Re‐examining the evidence that ivermectin induces a melanoma‐like state in Xenopus embryos
Authors: Hutchison Ainsley , Sibanda Chiedza , Hulme Mackenzie , Anwar Sarah , Gur Bengisu , Thomas Rachael , Lowery Laura Anne 
Published: November 2023

AbstractModeling metastasis in animal systems has been an important focus for developing cancer therapeutics. Xenopus laevis is a well‐established model, known for its use in identifying genetic mechanisms underlying diseases and disorders in humans. Prior literature has suggested that the drug, ivermectin, can be used in Xenopus to induce melanocytes to convert into a metastatic melanoma‐like state, and thus could be ideal for testing possible melanoma therapies in vivo. However, there are notable inconsistencies between ivermectin studies in Xenopus and the application of ivermectin in mammalian systems, that are relevant to cancer and melanoma research. In this review, we examine the ivermectin‐induced phenotypes in Xenopus, and we explore the current uses of ivermectin in human research. We conclude that while ivermectin may be a useful drug for many biomedical purposes, it is not ideal to induce a metastatic melanocyte phenotype in Xenopus for testing the effects of potential melanoma therapeutics.
Key leaders' sustainable decision making: The roles of key leaders' sustainability mindset
Authors: Mai Bui Thi Thanh , Mai Le Thi Thu , Hung Nguyen Vu , Anh Vu Tuan 
Published: November 2023

AbstractIn order to achieve a competitive advantage in the market, enhance a positive brand reputation, and respond to consumers' requirement, organizations' key leaders may have to make sustainable decisions for the sake of the environment, the society and the organization simultaneously. In this study, Buddhism and compassion are proposed to extend the sustainability mindset framework in understanding key leaders' sustainable decision making to achieve a balance between concerns for environmental, societal, and economic outcomes. Data from a survey of 142 key leaders who are business owners, entrepreneurs, and managers in SMEs and startups in Vietnam provide evidence that Buddhist teaching and lifestyles are important predictors of key leaders' sustainable decision making through the mediator of compassion. Furthermore, the study also revealed that Buddhism positively and significantly influences compassion. This research, thus, makes contribution to the extant literature regarding factors influencing key leaders' sustainable decision making. Practical implications are also discussed.
Youtiao: Effect of ingredients and processing on quality attributes
Authors: Zhu Fan 
Published: November 2023

AbstractBackground and ObjectivesYoutiao (oil stick), a popular food product in East and Southeast Asia, is a deep‐fried stick of wheat flour dough. The basic ingredients include wheat flour, water, leavening agent, and frying oil. The ingredients are mixed to form a dough, which is proofed and shaped before deep‐frying. There have been variations in the quality of youtiao from the market as the production is upscaling toward the industrial level. Consumers demand healthier formulations of youtiao. A better understanding of property–quality relationships of youtiao components is essential to meet these demands. This mini‐review summarizes the sensory quality and flavor attributes of youtiao. The effects of basic and optional ingredients, chemical components, and processing on the quality of youtiao are presented. Quality evaluation of youtiao and the occurrence of chemical toxins are also described. The property–quality relationships of youtiao components are discussed. Future research directions on how to improve the youtiao quality are suggested.FindingsYoutiao contains a range of chemical toxins including polycyclic aromatic hydrocarbons, acrylamide, 5‐hydroxymethylfurfural, 3‐monochloropropane‐1,2‐diol fatty acid esters, and aluminum. The textural, sensory, and chemical properties of youtiao are affected by the interactions between basic ingredients, optional ingredients, and processing operations. Suitable wheat varieties and frying oils should be chosen to make youtiao with desirable sensory properties. Optional ingredients, such as starch‐based nonwheat flours, hydrocolloids, and antioxidants, showed potential to improve various aspects of youtiao quality. Frozen dough technology is promising for industrial‐scale production of youtiao.ConclusionsVariation in the quality of youtiao from different manufacturers is large. There are many research opportunities to improve the quality of youtiao.Significance and NoveltyYoutiao represents a typical model system of deep‐fried cereal foods, which are under‐studied as compared with other cereal and grain‐based foods. This review systematically analyzed different aspects of youtiao quality for the first time, and may stimulate further interest in the studies of fried cereal and grain‐based foods.
Monolithic Porous Organic Polymer‐Photocatalyst Composites for Applications in Catalysis
Authors: Venditto Vincenzo , Vaiano Vincenzo , Sacco Olga 
Published: November 2023

AbstractThis Review provides a perspective on porous organic polymer‐photocatalyst composites obtained by coupling semiconductors and hydrophilic/hydrophobic polymers which do not modify the properties of the embedded photocatalysts, but can influence the efficiency of the overall catalytic process. Particular attention has been given to polymer composites in the form of monolithic hydrogel/sponge/aerogels obtained by dissolving the polymer in a solvent, which contains the photocatalyst dispersed, inducing gelation or solidification of the solution and subsequently removing the solvent by a drying process. The photocatalytic applications discussed here cover H2 evolution from water splitting, CO2 reduction, and organic synthesis. Indeed, the main aim of this Review is to outline an alternative perspective to the highly studied environmental photocatalytic applications, highlighting the photoactive properties of these composites thanks to the incorporation of semiconductors in the 3D porous structure of organic polymers. Finally the challenges and potential advances associated with the use of porous organic polymer‐photocatalyst composites for future scientific research are outlined.
Seawater to Green Hydrogen: Future of Green Energy
Authors: Loomba Suraj , Khan Muhammad Waqas , Mahmood Nasir 
Published: November 2023

AbstractWater electrolysis to produce hydrogen has been viewed as the future of green energy. The reliance of current electrolyzer technologies on ultrapure fresh water is not feasible to meet increasing hydrogen demands. The abundant seawater emerged as the potential feedstock for water electrolysis, but its complex composition and chlorine chemistry make the process complicated. Recently designed effective catalysts have given hope for direct seawater splitting but need to be optimized for commercial use. Moreover, the inability of current electrolyzer technologies with seawater requires efforts to establish this technology. In short, freshwater as feed for water electrolysis is not sustainable; the focus must be on seawater. While desalination seems to be a viable option, the economics of scale of the plant is critical in assessing its viability. Although the complex composition of seawater makes direct seawater splitting challenging, designing effective catalysts and durable electrolyzers can make it possible for a truly sustainable hydrogen industry.
Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with atypical glandular cells cytology: A retrospective analysis of 369 cases
Authors: Zhou Xin , Lin Wanrun , Qin Yiming , Zhang Jing , Zhang Xiaofei , Zhang Huijuan , Zheng Wenxin , Zhou Feng 
Published: November 2023

AbstractBackgroundThis study aims to assess the immediate risk of cervical precancers and cancers in women with atypical glandular cells (AGC) cytology, based on high‐risk human papillomavirus (hrHPV) genotypes and age.MethodsA retrospective analysis was conducted on 369 cases of AGC with immediate follow‐up biopsy results, including 299 AGC‐not otherwise specified (NOS) and 70 AGC‐favor neoplastic (FN).ResultsAmong the 369 AGC cases, 127 tested positive for hrHPV (34.4%). The predominant high‐risk type was other 11 genotypes (44.1%), followed by 16+ (29.1%), 18/45+ (26.0%), and 16 and 18/45 double‐positive (0.79%). Precancers and cancers were detected in 30.4% (112 of 369) and 9.8% (36 of 369) of cases, respectively. The HPV‐18/45+ group had notably higher adenocarcinoma in situ and adenocarcinoma (AIS+) prevalence compared to other 11 genotype groups (p < .0001 and p = .001, respectively). The HPV‐16+ group showed significantly higher high‐grade cervical squamous epithelial lesion and squamous cell carcinoma prevalence than other 11 genotype groups (p < .0001 and p = .017, respectively). Using 40‐year cutoff, older women had significantly higher prevalence of abnormal glandular lesion+ lesions (17.6% vs. 7.6%, p = .005) and adenocarcinoma (AC) (12.4% vs. 2.5%, p = .001). Using 50‐year cutoff, older women had higher prevalence of squamous cell carcinoma (SCC) (3.3% vs. 0.4%, p = .042) and AC (15.2% vs. 5.8%, p = .005). Subgroup analysis revealed that AGC‐FN women showed more severe cervical pathology than AGC‐NOS women (p < .001).ConclusionsAGC women have a significantly increased risk of cervical precancerous lesions and cancer. HPV genotyping and patient age factors need to be taken into consideration in the clinical management process of AGC patients.
Critical sets of solutions of elliptic equations in periodic homogenization
Authors: Lin Fanghua , Shen Zhongwei 
Published: November 2023

AbstractIn this paper we study critical sets of solutions of second‐order elliptic equations in divergence form with rapidly oscillating and periodic coefficients. Under some condition on the first‐order correctors, we show that the ‐dimensional Hausdorff measures of the critical sets are bounded uniformly with respect to the period , provided that doubling indices for solutions are bounded. The key step is an estimate of “turning” of an approximate tangent map, the projection of a non‐constant solution onto the subspace of spherical harmonics of order , when the doubling index for on a sphere is trapped between and , for between 1 and a minimal radius . This estimate is proved by using harmonic approximation successively. With a suitable renormalization as well as rescaling we are able to control the accumulated errors introduced by homogenization and projection. Our proof also gives uniform bounds for Minkowski contents of the critical sets.
A 19‐color single‐tube full spectrum flow cytometry assay for the detection of measurable residual disease in acute myeloid leukemia
Authors: Fokken Hendrik , Waclawski Julian , Kattre Nadine , Kloos Arnold , Müller Sebastian , Ettinger Max , Kacprowski Tim , Heuser Michael , Maetzig Tobias , Schwarzer Adrian 
Published: November 2023

AbstractMultiparameter flow cytometry (MFC) has emerged as a standard method for quantifying measurable residual disease (MRD) in acute myeloid leukemia. However, the limited number of available channels on conventional flow cytometers requires the division of a diagnostic sample into several tubes, restricting the number of cells and the complexity of immunophenotypes that can be analyzed. Full spectrum flow cytometers overcome this limitation by enabling the simultaneous use of up to 40 fluorescent markers. Here, we used this approach to develop a good laboratory practice‐conform single‐tube 19‐color MRD detection assay that complies with recommendations of the European LeukemiaNet Flow‐MRD Working Party. We based our assay on clinically‐validated antibody clones and evaluated its performance on an IVD‐certified full spectrum flow cytometer. We measured MRD and normal bone marrow samples and compared the MRD data to a widely used reference MRD‐MFC panel generating highly concordant results. Using our newly developed single‐tube panel, we established reference values in healthy bone marrow for 28 consensus leukemia‐associated immunophenotypes and introduced a semi‐automated dimensionality‐reduction, clustering and cell type identification approach that aids the unbiased detection of aberrant cells. In summary, we provide a comprehensive full spectrum MRD‐MFC workflow with the potential for rapid implementation for routine diagnostics due to reduced cell requirements and ease of data analysis with increased reproducibility in comparison to conventional FlowMRD routines.
Vangunu giant rat (Uromys vika) survives in the Zaira Community Resource Management Area, Solomon Islands
Authors: Lavery Tyrone H. , Holland Adrian , Jino Nixon , Judge Atuna , Judge Hikuna , Onga Pandakai , Sese Kevin 
Published: November 2023

AbstractDescribed in 2017 and known only from the holotype, Uromys vika is surely among the world's least studied rodents. This critically endangered species is facing a rapidly increasing scale for threat from logging of its primary lowland forest habitat, on the only island on which it occurs—Vangunu, Solomon Islands. However, a deep traditional ecological knowledge of U. vika is held by Vangunu's people. Using camera traps and guided by this knowledge, we aimed to make additional records of U. vika in the last major block of Vangunu's primary forest. We successfully captured 95 images of what we postulate is four different individuals. The forests at Zaira represent the last suitable habitat remaining for this species, and recent development consent for logging at Zaira will lead to its extinction if permitted to proceed.
Synthesis of Aromatic Nitriles by SmI2‐Mediated Reductive Cleavage of Cyanoximes
Authors: Xie Dengbing , Lin Ming , Wang Pengkai , Zhang Lingyu , Zhang Songlin 
Published: November 2023

AbstractThe reduction of cyanoximes to aromatic nitriles is reported for the first time, via N‐centered anions from the reductive cleavage of N−ΘΘΘΘΘΘO bond in cyanoximes promoted by SmI2. A mild, safe, and efficient method for the synthesis of aromatic nitriles in a one‐pot fashion with excellent yields was developed.
Correlation between migraine and cerebral small vessel disease: A case–control study
Authors: Zhang Yanan , Li Yanbo , He Li 
Published: November 2023

AbstractBackgroundMicrocirculatory pathology is one of the pathophysiological theories of migraine, which may present as visually subclinical lesions. Image markers of cerebral small vessel disease (CSVD) have been investigated in elderly migraineurs. However, past studies looked at only part of image features, and the conclusions may have been hindered by confounding factors. The relationship between migraine and CSVD signs needs reliable demonstrations.MethodsWe conducted a case–control study by recruiting episodic young migraineurs from a tertiary headache centre, with tension‐type headache (TTH) and healthy controls. Distinct image features of microvascular damage and baseline characteristics across groups were assessed, and multivariate linear regression was performed to evaluate the risk factors for image abnormalities in migraineurs.ResultsForty‐eight migraineurs, 32 TTHs and 49 healthy controls were included. The median age was 32 year‐old. 58.7% of the participants were female. The Scheltens score and volume of white matter hyperintensities (WMHs) in migraineurs, and the number of Virchow–Robin spaces (VRSs) in both migraineurs and TTHs were different from those in normal controls. No lacunar infarct‐like lesions (ILLs) or cerebral microbleeds (CMBs) were found. Age, education level (high level: β = −2.23, lobar WMHs), attack duration (long duration: β = 3.81, lobar WMHs) and attack frequency were independent risk factors for Scheltens score and volume of WMH in migraineurs. Migraine aura (β = −2.389), attack frequency and education level were correlated with the number of VRSs.ConclusionsMigraine was associated with WMHs and VRSs. Aura, attack duration, attack frequency, age and education level were risk factors for image abnormalities of CVSD in migraineurs.SignificanceThis study provides a novel and comprehensive landscape of CSVD MRI features in young migraineurs, and it fills the blank of CMBs and VRSs which received less attention, with more persuasive, more reliable and stronger evidence of the association between CSVD and migraine. Our results also imply some new feature of TTH and the possible pathophysiology of the migraine course as well as new clues for the early management of migraine in terms of visual brain damage.
CFA‐treated mice induce hyperalgesia in healthy mice via an olfactory mechanism
Authors: Zhang Yangmiao , Luo Wentai , Heinricher Mary M. , Ryabinin Andrey E. 
Published: November 2023

AbstractBackgroundSocial interactions with subjects experiencing pain can increase nociceptive sensitivity in observers, even without direct physical contact. In previous experiments, extended indirect exposure to soiled bedding from mice with alcohol withdrawal‐related hyperalgesia enhanced nociception in their conspecifics. This finding suggested that olfactory cues could be sufficient for nociceptive hypersensitivity in otherwise untreated animals (also known as “bystanders”).AimThe current study addressed this possibility using an inflammation‐based hyperalgesia model and long‐ and short‐term exposure paradigms in C57BL/6J mice.Materials & MethodAdult male and female mice received intraplantar injection of complete Freund's adjuvant (CFA) and were used as stimulus animals to otherwise naïve same‐sex bystander mice (BS). Another group of untreated mice (OLF) was simultaneously exposed to the bedding of the stimulus mice.ResultsIn the long‐term, 15‐day exposure paradigm, the presence of CFA mice or their bedding resulted in reduced von Frey threshold but not Hargreaves paw withdrawal latency in BS or OLF mice. In the short‐term paradigm, 1‐hr interaction with CFA conspecifics or 1‐hr exposure to their bedding induced mechanical hypersensitivity in BS and OLF mice lasting for 3 hrs. Chemical ablation of the main olfactory epithelium prevented bedding‐induced and stimulus mice‐induced mechanical hypersensitivity. Gas chromatography‐mass spectrometry (GC‐MS) analysis of the volatile compounds in the bedding of experimental mice revealed that CFA‐treated mice released an increased number of compounds indicative of disease states.Discussion and ConclusionThese results demonstrate that CFA‐induced inflammatory pain can modulate nociception in bystander mice via an olfactory mechanism involving dynamic changes in volatile compounds detectable in the rodent bedding.SignificanceSocial context can influence nociceptive sensitivity. Recent studies suggested involvement of olfaction in this influence. In agreement with this idea, the present study shows that the presence of mice with inflammatory pain produces nociceptive hypersensitivity in nearby conspecifics. This enhanced nociception occurs via olfactory cues present in the mouse bedding. Analysis of the bedding from mice with inflammatory pain identifies a number of compounds indicative of disease states. These findings demonstrate the importance of olfactory system in influencing pain states.
Calibrated forecasts of quasi‐periodic climate processes with deep echo state networks and penalized quantile regression
Authors: Bonas Matthew , Wikle Christopher K. , Castruccio Stefano 
Published: November 2023

AbstractAmong the most relevant processes in the Earth system for human habitability are quasi‐periodic, ocean‐driven multi‐year events whose dynamics are currently incompletely characterized by physical models, and hence poorly predictable. This work aims at showing how (1) data‐driven, stochastic machine learning approaches provide an affordable yet flexible means to forecast these processes; (2) the associated uncertainty can be properly calibrated with fast ensemble‐based approaches. While the methodology introduced and discussed in this work pertains to synoptic scale events, the principle of augmenting incomplete or highly sensitive physical systems with data‐driven models to improve predictability is far more general and can be extended to environmental problems of any scale in time or space.
Edible gums—An extensive review on its diverse applications in various food sectors
Authors: Kadirvel Vijayasri , Narayana Gururaj P. 
Published: November 2023

AbstractIn recent years, the extraction, processing, and application of edible gums, in the food and healthcare sector has skyrocketed and extensively explored. Edible gums are derived from multiple sources such as plants/trees, animals, microorganisms, and seaweed. Edible gums are typically employed to perform certain functions including modification of rheology, gel formation, stability, encapsulation, and fat replacement. The unique interaction of edible gums with food molecules enables the achievement of desired characteristics of specific food products belonging to various sectors. This review delivers a comprehensive understanding of the classification and characterization of edible gums and their applications in the food industry. Despite several advantages offered by edible gums, there exist certain challenges that are encountered during commercialization by manufacturers and proposed strategies to overcome the hurdles, regulatory aspects, and safety of edible gums upon consumption have been highlighted in this review.