bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of implant stability between implant placed without bone graft versus with bone graft using GBR technique : a resonance frequency analysis
Authors:   , Janyaphadungpong Ruengsiri 
Published: November 2023

Objective : To compare the implant stability using the insertion torque (IT) and implant stability quotient (ISQ) values over the 12 weeks period between implant placement in bone without bone graft (control group) and with bone graft using the guided bone regeneration (GBR) technique (study group). The secondary objective was to assess the correlation between the IT and ISQ values of the two groups
Materials and Methods : In the control group, 20 implants were placed in bone without bone regeneration in 15 patients, whereas in the study group, 10 implants were placed in favorable bone defects at buccal aspect with simultaneous guided bone regeneration in 7 patients. IT (Ncm) of each implant was recorded when fully inserted. ISQ values were obtained from the Osstell® ISQ at the time of implant placement, and at 2, 4, 8, and 12 weeks. The differences between two groups were analyzed by the t-test, the Mann-Whitney U test and the Repeated measures ANOVA. The Pearson and the Spearman correlation tests were used to analyze statistical correlations. All of the analyses were performed using a 95% confidence level.

Results : The mean IT values of the control group was 27.75 ± 8.96 Ncm and the study groups was 30.5 ± 8.96 Ncm. No difference in IT was found between the two groups (P = 0.502). The mean ISQ values at baseline and at 2, 4, 8, and 12 weeks of the control group were 74.30 ± 6.01, 69.58 ± 5.30, 71.10 ± 5.80, 75.08 ± 3.93 and 77.85 ± 3.18, respectively, and the mean ISQ values of the control group were 69.85 ± 7.00, 63.40 ± 8.47, 59.90 ± 10.23, 72.55 ± 3.10 and 76.20 ± 2.68. Statistically significant differences in the mean ISQ values between the control and study groups were found at 2 weeks (P = 0.021) and at 4 weeks (P = 0.007). There was no significant correlation between the IT and ISQ values of the control and study groups.
Conclusions: There was no difference in IT between the control and study groups, while the difference in the changes of ISQ values during the 12 weeks healing period between implant placement without bone graft and with bone graft using the guided bone regeneration (GBR) technique were found. There was no correlation between the IT and ISQ values.
Effect of Ramadan Fasting on Circulating Leptin and Adiponectin Levels and Metabolic Profiles in Healthy Men Thai Muslim Population
Authors:   , Prasetya Guntari 
Published: November 2023

Ramadan fasting, the 9th month of Islamic lunar calendar is one of the religious worship among Muslims. All healthy adult Muslims must refrain from eating, drinking, smoking, and sexual relationship from dawn to dusk. Ramadan fasting, a unique model of intermittent fasting has been investigated since the last 5 decades and the heterogeneous findings regarding to the impact of this Islamic fasting in health and certain diseases gain more investigations. Aim of this study is to determine the effect of Ramadan fasting on circulating leptin and adiponectin levels and metabolic profiles in healthy men. One month (29 days) of Ramadan fasting in a year of 2015 was conducted (before and after three weeks of Ramadan fasting). Twenty seven healthy men (19-31 years) were eligible and completed study. The outcomes measured in comparison at before and after three weeks of Ramadan fasting were including biochemical parameters (circulating serum leptin and adiponectin and metabolic profiles: fasting plasma glucose, insulin, and lipid profile); anthropometry, body composition, dietary intake and physical activity. Ramadan fasting did not pose significant changes on circulating leptin and adiponectin levels. Serum total cholesterol and high-density lipoprotein cholesterol (HDL-c) were decreased significantly, while fasting plasma glucose, serum insulin, low-density lipoprotein cholesterol (LDL-c), triglycerides, and homeostasis model assessment of insulin resistance (HOMA-IR) index were remained unchanged. A significant reduction in body weight, BMI, fat mass, fat free mass, muscle mass, and waist and hip circumferences were noted after three weeks of Ramadan fasting. Energy, carbohydrate, and fat intake were decreased significantly, whereas physical activity was remained unchanged. In conclusion, despite of modulation in metabolic profiles and improvement in body composition, Ramadan fasting did not significantly alter circulating leptin and adiponectin levels. Further extensive studies is needed to validate and determine the clinically effect of Ramadan fasting in healthy men.
Degradation of (E)- and (Z)-Endoxifen: Kinetics, By-products Identification and Toxicity Assessment.
Authors:   , Martin Marina 
Published: November 2023

Endoxifen is an effective metabolite of a commonly used chemotherapy agent, tamoxifen. Endoxifen has been detected in the final effluent of wastewater treatment plants. The release of endoxifen into the water environment could bring negative effect to aquatic lives due to its antiestrogenic activity. This research investigated the uses of isolated bacteria strains and ultraviolet (UV) radiation (253.7 nm) to degrade endoxifen in water and wastewater, and the generations of degradation by-products and their toxicity. Biodegradation of endoxifen by isolated bacteria strains from wastewater resulted in inefficient degradation of (E)- and (Z)-endoxifen. However, photodegradation with UV light eliminated endoxifen from water by at least 99.1% after 35 seconds of irradiation with a light dose of 598.5 mJ cm-2. Light intensity and initial concentrations of (E)- and (Z)-endoxifen exhibited positive linear correlations with the photodegradation rates while pH had no effect. Photodegradation of (E)-and (Z)-endoxifen in water generated three photodegradation by-products (PBPs). Toxicity assessments through modeling of the identified PBPs suggest higher toxicity than the parent compounds. Photodegradation of (E)- and (Z)-endoxifen in wastewater at light doses used for disinfection in wastewater treatment plants (WWTPs) resulted in reduction of (E)- and (Z)-endoxifen by at least 30, 44, and 71% at the light doses of 16, 30, and 97 mJ cm-2, respectively. Two of the three PBPs observed in the experiments with water were detected in the experiments in wastewater. Therefore, highly toxic compounds are potentially generated at WWTPs during UV disinfection process if (E)- and (Z)-endoxifen are present in the treated wastewater.
Biodegradation of hydrocarbons in marine sediment from Bangkhuntien, Bangkok, Thailand
Authors:   , Tiralerdpanich Parichaya 
Published: November 2023

Biological method is an important alternative for solving petroleum hydrocarbon contamination issue because it is environmental friendly, low cost and has a potential to effectively remediate the oil. The objectives of this study were; 1) to estimate the biodegradation rate of diesel, hexadecane, and phenanthrene in marine sediment by using Gas Chromatography with Flame Ionization Detector (GC-FID) to monitor the remaining amount of hydrocarbons and constructing the degradation plot of each hydrocarbon per time for calculation of the degradation rate, 2) to investigate the hydrocarbon-degrading bacterial community in marine sediment by Polymerase Chain Reaction-Denaturing Gradient Gel Electrophoresis (PCR-DGGE) technique and 3) to isolate diesel-, hexadecane- and phenanthrene-degrading bacteria using media with each hydrocarbon as a sole carbon source. In this study, there were 3 interesting hydrocarbons including diesel, hexadecane and phenanthrene. The marine sediments were collected from Bangkhuntien, Thailand to use as a surrogate of a chronically hydrocarbon contaminated bay marine ecosystem. The results from hydrocarbon-contaminated microcosms showed that the removal percentage and the degradation rates for 500 mg kg sediment-1 diesel were 84% and 81.96 mg kg sediment-1 day-1, for 250 mg kg sediment-1 hexadecane were 99% and 86.43 mg kg sediment -1 day-1 and for 125 mg kg sediment-1 phenanthrene were 96% and 9.03 mg kg sediment-1 day-1, respectively. The dominant bacterial populations analyzed by PCR-DGGE technique were mostly recognized as halophilic- hydrocarbon degrading bacteria. The isolated strains from enrichment technique were belonged to Acinobacter sp., Bacillus sp. and Staphylococcus sp. from hexadecane supplemented broth. We also isolated Pseudomonas sp. from phenanthrene supplemented broth and Bacillus sp. and Pseudomonas sp. from diesel supplemented broth. Although, the species of isolated bacteria were different from those detected by PCR-DGGE technique. The overall results suggested that bioremediation and indigenous bacteria in marine sediments could be applied to treat the contaminated hydrocarbons.
Effect of Learning Management Using Project-Based Learning on Graphic Design Ability of Sophomore Students at Suzhou Institute of Art and Design, the People's Republic of China
Authors: Jie Liu , Choicharoen Thapana , Juithong Suwana 
Published: November 2023

Background and Aim: The twenty-first Century is the digital era, with the rapid development of science and technology. Schools and all levels of educational institutes, as places that educate theoretical knowledge to students and develop their practical ability revising the plan and supplementing the teaching materials include developing teaching and learning strategies to promote student abilities and 21st-century skills. The current situation in many art and design institutes are quality of learning and teaching especially strategies to improve the design ability of students according to the trend of graphic design at the global level. Graphic design ability is one of the major abilities of a student who studies in the field of fine and applied art previous educators researched and reported that Learning Management Using Project-Based Learning (PBL) combines curriculum with practice to improve students' initiative, stimulate students' flexible use of knowledge to solve practical problems, and can support the student to develop ability skill and competency. This research aim is composed of 1) to study students' Graphic Design Ability after Learning Management Using project-based learning (PBL) and 2) To assess Students' Satisfaction with Learning Management Using project-based learning (PBL).
Materials and Methods: Instruments were (1) an Instrument for the experiment a Lesson plan: 5 lesson plans each lesson plan for 3 hours, 15 hours in total, (2) an Instrument for collecting data composed of: 1) Graphic design ability evaluation form 2) Student satisfaction questionnaire. Methods were (1) The samples were Learned toward learning management using project-based learning. (2) After the samples learned about learning management using project-based learning. The samples were evaluated for Graphic Design Ability by evaluation and student satisfaction through a satisfaction questionnaire.
Results: Found that: (1) After learning management using project-based learning, students’ Graphic Design Ability was which was statistically higher than the determined criterion set 70%. (2) After learning management using project-based learning students’ satisfaction with Learning Management Using project-based learning was high level.
Conclusion: After learning management using project-based learning, students’ Graphic Design Ability of student statistically higher than the determined criterion set of 70%. and students’ satisfaction with learning management using project-based learning was high level.
Identification of key genes in sepsis-induced cardiomyopathy based on integrated bioinformatical analysis and experiments in vitro and in vivo
Authors: Liu Dehua , Wang Tao , Wang Qingguo , Dong Peikang , Liu Xiaohong , Li Qiang , Shi Youkui , Li Jingtian , Zhou Jin , Zhang Quan 
Published: November 2023

Introduction
Sepsis is a life-threatening disease that damages multiple organs and induced by the host’s dysregulated response to infection with high morbidity and mortality. Heart remains one of the most vulnerable targets of sepsis-induced organ damage, and sepsis-induced cardiomyopathy (SIC) is an important factor that exacerbates the death of patients. However, the underlying genetic mechanism of SIC disease needs further research.

Methods
The transcriptomic dataset, GSE171564, was downloaded from NCBI for further analysis. Gene expression matrices for the sample group were obtained by quartile standardization and log2 logarithm conversion prior to analysis. The time series, protein-protein interaction (PPI) network, and functional enrichment analysis via Gene Ontology and KEGG Pathway Databases were used to identify key gene clusters and their potential interactions. Predicted miRNA-mRNA relationships from multiple databases facilitated the construction of a TF-miRNA-mRNA regulatory network. In vivo experiments, along with qPCR and western blot assays, provided experimental validation.

Results
The transcriptome data analysis between SIC and healthy samples revealed 221 down-regulated, and 342 up-regulated expressed genes across two distinct clusters. Among these, Tpt1, Mmp9 and Fth1 were of particular significance. Functional analysis revealed their role in several biological processes and pathways, subsequently, in vivo experiments confirmed their overexpression in SIC samples. Notably, we found TPT1 play a pivotal role in the progression of SIC, and silencing TPT1 showed a protective effect against LPS-induced SIC.

Conclusion
In our study, we demonstrated that Tpt1, Mmp9 and Fth1 have great potential to be biomarker of SIC. These findings will facilitated to understand the occurrence and development mechanism of SIC.
Sulforaphene suppressed cell proliferation and promoted apoptosis of COV362 cells in endometrioid ovarian cancer
Authors: Yu Hui-Yan , Yang Li , Liu Yuan-Cai , Yu Ai-Jun 
Published: November 2023

Aim
N6-methyladenosine (m6A) RNA methylation exerts a regulatory effect on endometrioid ovarian cancer (EOC), but the specific m6A regulator genes in EOC remain to be explored. This study investigated that sulforaphene (Sul) is implicated in EOC development by regulating methyltransferase-like 3 (METTL3).

Methods
The dysregulated m6A RNA methylation genes in EOC were determined by methylated RNA immunoprecipitation (MeRIP-seq) and RNA sequencing. The roles of METTL3 and/or Sul on viability, proliferative ability, cell cycle, and apoptosis of EOC cells were determined by MTT, colony formation, flow cytometry, and TUNEL staining assay, respectively. The expression of METTL3 and apoptosis-related proteins in EOC cells was detected by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays.

Results
Five m6A RNA methylation regulators (METTL3, ELF3, IGF2BP2, FTO, and METTL14) were differentially expressed in EOC, among which METTL3 had the highest expression level. Silencing METTL3 reduced the clonal expansion and viability of EOC cells, and caused the cells to arrest in the G0/G1 phase. This also promoted apoptosis in the EOC cells and activated the FAS/FADD and mitochondrial apoptosis pathways. In contrast, overexpressing METTL3 had the opposite effect. Sul, in a dose-dependent manner, reduced the viability of EOC cells but promoted their apoptosis. Sul also increased the levels of IGF2BP2 and FAS, while decreasing the levels of KRT8 and METTL3. Furthermore, Sul was able to reverse the effects of METTL3 overexpression on EOC cells.

Conclusions
Sul could suppress cell proliferation and promote apoptosis of EOC cells by inhibiting the METTL3 to activate the FAS/FADD and apoptosis-associated pathways.
Chicago sky blue gel for better visualization of Demodex in patients with Demodex blepharitis
Authors: Udomwech Lunla , Tawanwongsri Weeratian , Mordmuang Auemphon 
Published: November 2023

Background
Demodex blepharitis is a common chronic disease. The number of mites is associated with ocular discomfort. The accurate number derived from well-stained specimens is, hence, in favor of diagnosing, monitoring, and determining treatment responses.

Methods
A cross-sectional study was conducted between April and July 2022 at the dermatology and ophthalmology clinic, Walailak University, Thailand. Adult participants with clinical suspicion of Demodex blepharitis were recruited. We examined eyelashes under light microscopy to quantify the number of Demodex mites before and after adding CSB gel. The mite counts, evaluated by an untrained investigator and an experienced investigator, were recorded and compared.

Results
A total of 30 participants were included for final analysis, among which 25 (83.3%) were female. The median age was 64.0 years (IQR, 61.0–68.0). The median Demodex counts evaluated by the experienced investigator before and after adding CSB gel were 1.0 (IQR, 0.0–1.0) and 2.5 (IQR, 2.0–3.0), respectively (p < 0.001). Moreover, the median Demodex counts evaluated by the untrained investigator before and after adding CSB gel were 1.0 (IQR, 0.0–1.0) and 2.0 (IQR, 1.0–3.0), respectively (p < 0.001). The correlation coefficient between Demodex counts after the addition of CSB counted by the experienced investigator and those counted by the untrained investigator was 0.92 (p < 0.001). CSB gel is a promising product to identify and quantify the number of Demodex mites. The findings supported the consideration of CSB gel as one of the diagnostic stains.
FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma
Authors: Liao Qingyun , Yang Jing , Lu Zhaoyi , Jiang Qingshan , Gong Yongqian , Liu Lijun , Peng Hong , Wang Qin , Zhang Xin , Liu Zhifeng 
Published: November 2023

Background
Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear.

Methods
Herein, we analyzed the expression level of FTH1 in HNSCC using TCGA database, and FTH1 protein in HNSCC tissues and cell lines was determined by immunohistochemistry (IHC) and western blotting, respectively. Then, its prognostic value and relationship with clinical parameters were investigated in HNSCC patients. Additionally, the biological function of FTH1 in HNSCC was explored.

Results
The current study showed that FTH1 is significantly overexpressed in HNSCC tissues and related to poor prognosis and lymph node metastasis of HNSCC. FTH1 knockdown could suppress the metastasis and epithelial-mesenchymal transition (EMT) process of HNSCC.

Conclusion
Our findings indicate that FTH1 plays a critical role in the progression and metastasis of HNSCC and can serve as a promising prognostic factor and therapeutic target in HNSCC.
Factors Explaining the Weakness of Intra-Regional Trade Flows in the ECOWAS Region
Authors: Ndao Mamadou Saidou 
Published: November 2023

With a GDP of over 628 billion dollars and a population of over 350 million, ECOWAS (Benin, Burkina Faso, Côte d'Ivoire, Ghana, Guinea, Mali, Niger, Nigeria, Senegal and Togo) was set to be one of Africa's most powerful economic blocs. However, at ECOWAS level, intracommunity trade is still low, and its share of world trade is around 0.3%. Moreover, intracommunity trade, which is estimated at 10% of the region's total trade, is also low compared with other regional blocs. The main objective of this article is to identify the main factors explaining the evolution of trade within ECOWAS. The augmented gravity model is used to show that economic and structural factors have a significant impact on intra-regional trade. Geographic, demographic and institutional factors play a key role in the evolution of intraregional trade.
Toward Ga‐Free Wavelength Extended 2.6 µm InAsP Photodetectors with High Performance
Authors: Park Suho , Kim Yeongho , Nguyen Phuc Dinh , Jeon Jiyeon , Chun Byong Sun , Lee Sang Jun 
Published: November 2023

AbstractShort‐wavelength infrared (SWIR) photodetectors are of great interest owing to their unique advantages of SWIR imaging such as better penetration ability and improved sensitivity that allow high‐resolution imaging. Commercially, extended InxGa1‐xAs heterojunction detectors with cut‐off wavelengths beyond λc = 1.7 µm are incorporated into SWIR imagers. However, their large dark current and limited cut‐off wavelength tunability prevent their widespread use in SWIR imaging. Herein, a novel InAs0.85P0.15 homojunction detector with λc = 2.6 µm is achieved through lattice and bandgap engineering with well‐designed InAsyP1‐y metamorphic buffers. Compared to conventional In0.83Ga0.17As/InP detectors with a lattice mismatch of f = 2.0%, the InAs0.85P0.15 detector with f = 2.7% exhibits full strain relaxation and lower surface roughness (2.4 nm due to its superior crystallinity). Photocarrier generation in the InAsP detector is more efficiently supported by a smaller entropy for electron–hole pair formation. The lower trap density and longer carrier lifetime of the InAsP detector decrease the dark current, leading to high uniform detectivities of ≈1.0 × 109 cm Hz1/2 W−1 over a wider voltage range at 300 K. Such an InAsP metamorphic detector with excellent photodetection capabilities is expected to find applications in the implementation of large‐format focal plane arrays for extended SWIR imaging.
Surface Engineering of Binder‐free Anodes of Bi and Cu Compounds with Se and Carbon Nanotubes to Improve Lithium‐ion Batteries
Authors: Rublova Yelyzaveta , Kong Xiangze , Lazarenko Vitalijs , Andzane Jana , Meija Raimonds , Viksna Arturs , Kallio Tanja , Erts Donats 
Published: November 2023

AbstractThis study focuses on the surface engineering of binder‐free anodes composed of Bi, Se, Cu, and carbon nanotubes to enhance lithium‐ion batteries. The anodes synthesized in this study showed promising electrochemical properties. However, issues with cycle stability, operational speed, and solid electrolyte interface (SEI) formation affected their overall performance. To address these challenges, the study applied different conductive polymers, namely PEO, CMC, and PEGDA‐co‐VC, to form artificial SEI layers. The application of these polymers altered the stability and efficiency of the electrodes, with the PEGDA‐co‐VC‐coated electrodes demonstrating significant stability and consistent capacity over numerous cycles.