bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stent Grafts Across the Elbow Joint for Access Salvage
Authors: Aronhime Shimon , Avital Yaniv , Balan Shmuel , Cherniavsky Alexei 
Published: December 2023

Purpose: Covered stent grafts (SGs) are currently being used in a wide variety of situations to maintain function and patency of hemodialysis access circuits. Stent grafts are rarely placed across the elbow joint (EJ), however, due to fear of stent fracture. This study reports on the experience and patency rates with SGs across the EJ. Materials and Methods: From April 2020 to August 2023, all procedures with SGs placed across the EJ were retrospectively analyzed. A total of 21 patients with SGs placed across the EJ were included in the study. The Covera Vascular Covered Stent (BD, Franklin Lakes, New Jersey, USA) was used in all cases. Of these, 18 were arteriovenous (AV) fistulae, and 3 were AV grafts. Stent grafts were placed for various pathologies, including residual stenosis, perforation, aneurysm, and thrombosis. Follow-up outcomes were obtained from angiographic images on follow-up angiography and included primary patency, primary assisted patency, and secondary patency. Results: The primary patency of the target lesion was 85% (CI=70%–100%) and 85% (CI=70%–100%) at 6 and 12 months, respectively. The primary assisted patency was 85% (CI=70%–100%) and 85% (CI=70%–100%) at 6 and 12 months, respectively. Secondary patency of the access circuit was 95% (CI=86%–100%) at 6 months and 89% (CI=75%–100%) at 12 months. The average follow-up duration was 393 days (range=27–768 days). There were no instances of stent fracture during follow-up. Conclusions: Stent grafts should be placed across the EJ for good short-term and mid-term patency rates. Clinical Impact The placement of stent grafts across the elbow joint in hemodialysis patients for access salvage is controversial due to the fear of stent fracture or occlusion. This retrospective study evaluated the placement of stent grafts for access salvage in 21 patients for various etiologies. Good patency rates were seen out to 12 months and no stent fractures were observed. Although longer term data is needed, stent grafts should be considered an acceptable option for access salvage when treating lesions that cross the elbow joint.
Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis
Authors: Mack Ethan A. , Dougher Meaghan C. , Ginda Ashley M. , Cahill Caitlin , Murter Melissa , Schell Kevin , Tanhehco Yvette C. , Bhoj Vijay G. , Fesnak Andrew D. , Siegel Don L. , Kambayashi Taku , Aqui Nicole A. , O’Doherty Una 
Published: December 2023

Abstract
We show that red cell exchange (RCE) treats hyperleukocytosis in acute leukemia. RCE provided similar leukoreduction to standard therapeutic leukoreduction and could be superior in patients with severe anemia or monocytic leukemias or when requiring rapid treatment.
Three years of maintenance with VRD in multiple myeloma: results of total therapy IIIB with a 15-year follow-up
Authors: Al Hadidi Samer , Ababneh Obada Ehab , Schinke Carolina D. , Thanendrarajan Sharmilan , Bailey Clyde , Smith Robert , Panozzo Susan , Alapat Daisy , Cottler-Fox Michele , Tricot Guido , Shaughnessy John D. , Zhan Fenghuang , Sawyer Jeffrey , Barlogie Bart , Zangari Maurizio , van Rhee Frits 
Published: December 2023

Abstract
The total therapy (TT) IIIB phase 2 study incorporated bortezomib into tandem melphalan–based hematopoietic stem cell transplantation with dexamethasone, thalidomide, cisplatin, doxorubicin, cyclophosphamide, and etoposide for induction/consolidation and bortezomib, lenalidomide, and dexamethasone (VRD) for maintenance in patients with newly diagnosed multiple myeloma (MM). This updated analysis presents a 15.4-year median follow-up. Of 177 patients, 21% patients had gene expression profile (GEP)–defined high-risk MM. 15-year progression free survival (PFS) was 27.9%. Median PFS was better in GEP–defined low-risk patients at 7.8 years and in International Staging System stage 1 patients at 8.7 years. Overall, median OS was 9.1 years, and 15-year overall survival (OS) was 35.9%. GEP–defined low-risk patients' median OS was 11.2 years, and that of GEP–defined high-risk patients was 2.8 years. There was no difference in OS between TT IIIB and TT IIIA. This study includes the longest follow-up of patients treated with maintenance VRD reported to date. In patients with GEP–defined low-risk, nearly half and one-third of patients without ongoing treatment showed no signs of progression at 10 and 15 years, respectively. One-third of patients survived more than 15 years, but 3 years of VRD maintenance did not improve outcomes for patients with GEP–defined high-risk MM. The study was registered on www.clinicaltrials.gov as #NCT00572169.
Glycerol and reuterin-producing Limosilactobacillus reuteri enhance butyrate production and inhibit Enterobacteriaceae in broiler chicken cecal microbiota PolyFermS model
Authors: Asare Paul Tetteh , Greppi Anna , Geirnaert Annelies , Pennacchia Alessia , Babst Angela , Lacroix Christophe 
Published: December 2023

Abstract
Background
Administering probiotic strains of Limosilactobacillus reuteri to poultry has been shown to improve poultry performance and health. Some strains of L. reuteri taxa can produce reuterin, a broad-spectrum antimicrobial compound from glycerol conversion, with high inhibitory activity against enterobacteria. However, little is known about the metabolism of glycerol in the complex chicken cecal microbiota nor the effect of glycerol, either alone or combined with L. reuteri on the microbiota. In this study, we investigated the effect of L. reuteri PTA5_F13, a high-reuterin-producing chicken strain and glycerol, alone or combined, on broiler chicken cecal microbiota composition and activity using the continuous PolyFermS model recently developed to mimic chicken cecal fermentation.

Methods
Three independent PolyFermS chicken cecal microbiota models were inoculated with immobilized cecal microbiota from different animals and operated continuously. The effects of two additional levels of glycerol (50 and 100 mM) with or without daily supplementation of chicken-derived L. reuteri PTA5_F13 (107 CFU/mL final concentration) were tested in parallel second-stage reactors continuously inoculated with the same microbiota. We analyzed the complex chicken gut microbiota structure and dynamics upon treatment using 16S rRNA metabarcoding and qPCR. Microbiota metabolites, short-chain and branched-chain fatty acids, and glycerol and reuterin products were analyzed by HPLC in effluent samples from stabilized reactors.

Results
Supplementation with 100 mM glycerol alone and combined with L. reuteri PTA5_F13 resulted in a reproducible increase in butyrate production in the three modelled microbiota (increases of 18 to 25%). Glycerol alone resulted also in a reduction of Enterobacteriaceae in two of the three microbiota, but no effect was detected for L. reuteri alone. When both treatments were combined, all microbiota quantitatively inhibited Enterobacteriaceae, including in the last model that had very high initial concentrations of Enterobacteriaceae. Furthermore, a significant 1,3-PDO accumulation was measured in the effluent of the combined treatment, confirming the conversion of glycerol via the reuterin pathway. Glycerol supplementation, independent of L. reuteri addition, did not affect the microbial community diversity.

Conclusions
Glycerol induced a stable and reproducible butyrogenic activity for all tested microbiota and induced an inhibitory effect against Enterobacteriaceae that was strengthened when reuterin-producing L. reuteri was spiked daily. Our in vitro study suggests that co-application of L. reuteri PTA5_F13 and glycerol could be a useful approach to promote chicken gut health by enhancing metabolism and protection against Enterobacteriaceae.
Transcriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor
Authors: Tang Qing , Xu Ying , Gao Feng , Xu Ying , Cheng Chaohua , Deng Canhui , Chen Jiquan , Yuan Xiaoge , Zhang Xiaoyu , Su Jianguang 
Published: December 2023

Abstract
Background
Cannabis sativa, a dioecious plant that has been cultivated worldwide for thousands of years, is known for its secondary metabolites, especially cannabinoids, which possess several medicinal effects. In this study, we investigated the autopolyploidization effects on the biosynthesis and accumulation of these metabolites, transcriptomic and metabolomic analyses were performed to explore the gene expression and metabolic variations in industrial hemp autotetraploids and their diploid progenitors.

Results
Through these analyses, we obtained 1,663 differentially expressed metabolites and 1,103 differentially expressed genes. Integrative analysis revealed that phenylpropanoid and terpenoid biosynthesis were regulated by polyploidization. No substantial differences were found in the cannabidiol or tetrahydrocannabinol content between tetraploids and diploids. Following polyploidization, some transcription factors, including nine bHLH and eight MYB transcription factors, affected the metabolic biosynthesis as regulators. Additionally, several pivotal catalytic genes, such as flavonol synthase/flavanone 3-hydroxylase, related to the phenylpropanoid metabolic pathway, were identified as being modulated by polyploidization.

Conclusions
This study enhances the overall understanding of the impact of autopolyploidization in C. sativa and the findings may encourage the application of polyploid breeding for increasing the content of important secondary metabolites in industrial hemp.
Characterization of the basic leucine zipper transcription factor family of Neoporphyra haitanensis and its role in acclimation to dehydration stress
Authors: Wang Li , Mo Zhaolan , Yu Xinzi , Mao Yunxiang 
Published: December 2023

AbstractBackgroundNeoporphyra haitanensis, a major marine crop native to southern China, grows in the harsh intertidal habitats of rocky coasts. The thallus can tolerate fluctuating and extreme environmental stresses, for example, repeated desiccation/rehydration due to the turning tides. It is also a typical model system for investigating stress tolerance mechanisms in intertidal seaweed. The basic leucine zipper (bZIP) transcription factors play important roles in the regulation of plants’ responses to environmental stress stimuli. However, little information is available regarding the bZIP family in the marine cropNh.haitanensis.ResultsWe identified 19bZIPgenes in theNh.haitanensisgenome and described their conserved domains. Based on phylogenetic analysis, these 19NhhbZIPgenes, distributed unevenly on the 11 superscaffolds, were divided into four groups. In each group, there were analogous exon/intron numbers and motif compositions, along with diverse exon lengths. Cross-species collinearity analysis indicated that 17 and 9NhhbZIPgenes were orthologous tobZIPgenes inNeopyropia yezoensisandPorphyra umbilicalis, respectively. Evidence from RNA sequencing (RNA-seq) data showed that the majority ofNhhbZIPgenes (73.68%) exhibited transcript abundance in all treatments. Furthermore, genes NN 2, 4 and 5 showed significantly altered expression in response to moderate dehydration, severe dehydration, and rehydration, respectively. Gene co-expression network analysis of the representative genes was carried out, followed by gene set enrichment analysis. TwoNhhbZIPgenes collectively responding to dehydration and rehydration and their co-expressing genes mainly participated in DNA repair, DNA metabolic process, and regulation of helicase activity. Two specificNhhbZIPgenes responding to severe dehydration and their corresponding network genes were mainly involved in macromolecule modification, cellular catabolic process, and transmembrane transport. Three specificNhhbZIPgenes responding to rehydration and their co-expression gene networks were mainly involved in the regulation of the cell cycle process and defense response.ConclusionsThis study provides new insights into the structural composition, evolution, and function of theNhhbZIPgene family. Our results will help us to further study the functions ofbZIPgenes in response to dehydration and rehydration inNh.haitanensisand improveNh.haitanensisin southern China.
Motivations for continued tobacco smoking and reasons for quitting among youths in Wakiso district, Uganda: a qualitative study
Authors: Daama Alex , Mugamba Stephen , Ddaaki William , Nalwoga Grace Kigozi , Kasango Asani , Nalugoda Fred , Bulamba Robert , Nkale James Menya , Kyasanku Emmanuel , Bulamu Ritah , Nakigozi Gertrude , Kigozi Godfrey , Kagaayi Joseph , Kisaka Stevens 
Published: December 2023

Abstract
Background
Efforts have been invested towards cessation of tobacco use among youths aged 18–35 years, however, motivators for continued tobacco smoking and reasons for quitting are limited in Ugandan settings. Therefore, this study aimed to explore motivations for continued tobacco smoking and reasons for quitting in Wakiso district Uganda.

Methods
This study used explanatory sequential method. Data from a Population-based survey collected from October 2019 to September 2020 was used to select participants for this qualitative study. Twenty-three in-depths interviews were conducted from July to October 2021 among youths (18-35years old) who reported continued tobacco use and those who quit. Data were analyzed using a team-based thematic content approach with the help of NVivo.

Results
Data was collected from a total of twenty three participants, fourteen were tobacco quitters and nine were current tobacco smokers. Recurrent habit, desire to complement the use of other drugs, peer pressure, using smoking as a replacement for alcohol consumption, low tobacco prices, smoking as a tradition were reported as motivators for continued tobacco smoking. However, reported reasons for quitting smoking by youths included; packaging health warnings, school based prevention programs, fear of associated health risks due to tobacco use, embarrassment from family members.

Conclusion
Targeted, and tailored tobacco prevention counselling through family support programs, intensified health education on the risks of smoking, and implementing stronger health warnings on tobacco packaging can be employed to reduce or stop tobacco use among urban youth.
Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients
Authors: Lin Kong-Ying , Chen Qing-Jing , Tang Shi-Chuan , Lin Zhi-Wen , Zhang Jian-Xi , Zheng Si-Ming , Li Yun-Tong , Wang Xian-Ming , Lu Qiang , Fu Jun , Guo Luo-Bin , Zheng Li-Fang , You Peng-Hui , Wu Meng-Meng , Lin Ke-Can , Zhou Wei-Ping , Yang Tian , Zeng Yong-Yi 
Published: December 2023

Abstract
Background
Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit from the inclusion of tumor biological marker alpha-fetoprotein (AFP) and systemic inflammation indicator C-reactive protein (CRP).

Methods
Data from a multicenter cohort of 2770 HCC patients undergoing hepatectomy were analyzed. We developed the PACE risk score (Prognostic implications of AFP and CRP Elevation) after initially assessing preoperative AFP and CRP’s prognostic value. Subgroup analyzes were performed in BCLC cohorts A and B using multivariable Cox analysis to evaluate the prognostic stratification ability of the PACE risk score and its complementary utility for BCLC staging.

Results
Preoperative AFP ≥ 400ng/mL and CRP ≥ 10 mg/L emerged as independent predictors of poorer prognosis in HCC patients who underwent hepatectomy, leading to the creation of the PACE risk score. PACE risk score stratified patients into low, intermediate, and high-risk groups with cumulative 5-year overall (OS) and recurrence-free survival (RFS) rates of 59.6%/44.9%, 43.9%/38.4%, and 20.6%/18.0% respectively (all P < 0.001). Increased PACE risk scores correlated significantly with early recurrence and extrahepatic metastases frequency (all P < 0.001). The multivariable analysis identified intermediate and high-risk PACE scores as independently correlating with poor postoperative OS and RFS. Furthermore, the PACE risk score proficiently stratified the prognosis of BCLC stages A and B patients, with multivariable analyses demonstrating it as an independent prognostic determinant for both stages.

Conclusion
The PACE risk score serves as an effective tool for postoperative risk stratification, potentially supplementing the BCLC staging system.
The role of Whitnall’s ligament position in the success of levator resection surgery in congenital ptosis
Authors: Jamshidian Tehrani Mansooreh , Kasaee Abolfazl , Zeidabadinejad Haniyeh , Shahriari Mansoor , Rafizadeh Seyed Mohsen 
Published: December 2023

Abstract
Purpose
This study aimed to investigate the role of Whitnall’s ligament position in the success of levator resection surgery in congenital ptosis.

Methods
It was an interventional case series on patients with congenital ptosis who underwent levator muscle resection in Farabi Eye Hospital (2020–2022). Patients with incomplete follow-up, a history of trauma, poor Bell’s phenomenon, previous ocular and lid surgeries, poor levator function (≤ 4mm), and syndromic ptosis or systemic diseases were excluded. During the surgery, several factors, including the distance between Whitnall’s ligament and the upper edge of the tarsus (W-distance), the vertical length of the tarsus (T-length), and the amount of levator muscle resection (LMR), were measured. A successful outcome was defined as the inter-eye difference of margin reflex distance-1 (MRD1) ≤ 1 and post-op MRD1 ≥ 3 OR the inter-eye difference of MRD1 ≤ 0.5 with any value of post-op MRD1 in unilateral cases and Postop-MRD1 > 3 in bilateral cases during the 3-months period.

Results
Thirty four eyes of 34 patients were included, and 79.4% of patients achieved successful outcomes. In univariate analysis, Preop-MRD1 and Preop-LF had meaningful negative correlations with the amount of LMR to reach the successful outcome (p < 0.05), which was only meaningful for Preop-LF in multivariable analysis (p < 0.05). Noticeably, W-distance had a significant positive correlation in univariate and multivariable linear regression (p < 0.05).

Conclusions
W-distance can be considered a significant new parameter other than Preop-LF influencing the amount of levator resection needed to achieve success in levator resection surgery.
Group brief cognitive behavioral therapy for suicide prevention compared to dialectal behavior therapy skills group for military service members: a study protocol of a randomized controlled trial
Authors: Baker Justin C. , Grover Shawna , Gunn Laura H. , Charles Cindy , Rikli Heather , Franks Michael J. , Khazem Lauren R. , Williams Sean , Ammendola Ennio , Washington Cherita , Bennette Marquita , Starkey Austin , Schnecke Kelly , Cain Shannon , Bryan Craig J. , Cramer Robert J. 
Published: December 2023

Abstract
Background
Suicide is a pressing matter for the military. Not only does it pose a health risk, but suicide also compromises operational readiness. Despite provision of suicide prevention clinical best practices, the Department of Defense suffers several challenges (e.g., clinician shortages) limiting the agency’s ability to effectively respond to service member suicide. Implementation of evidence-based suicide-specific group therapy is a possible solution to service member well-being needs and system challenges. Service members can also gain coping skills useful beyond managing suicidal thoughts and behaviors.

Methods
This 2-arm non-inferiority randomized controlled trial compares a group therapy format of Brief Cognitive Behavioral Therapy (i.e., G-BCBT) with Dialectical Behavior Therapy (DBT) Skills Group. Both therapies are delivered in-person at a United States Naval Medical Center. Participants (N = 136) are active-duty service members with recent suicidal thoughts or suicidal behavior. Evaluation features electronically delivered questionnaires at baseline, after each treatment session, and at 3- and 6-month follow-up.

Discussion
The primary outcome concerns G-BCBT impacts on suicidal ideation. Secondary outcomes of interest are suicide attempt, psychological distress (e.g., symptoms of depression, anxiety), and self-regulatory skills (e.g., emotion regulation). We also examine self-regulatory skills as treatment moderators. Clinical trial strengths and limitations are reviewed.

Trial registration
This study was registered at Clinicaltrials.gov (protocol NCT05401838).
Symptoms of post traumatic stress disorder and their relationship with the fear of COVID−19 and COVID−19 burden among health care workers after the full liberalization of COVID−19 prevention and control policy in China: a cross-sectional study
Authors: Liu Huan , Zhou Ningying , Zhou Zhiqing , Tao Xiubin , Kong Yan , Zhang Ming 
Published: December 2023

Abstract
Background
Over the past three years, the COVID-19 pandemic has brought an overwhelming impact on China’s hospital system and health care workers, which can lead to post traumatic stress disorder (PTSD) symptoms. Previous research has shown that the COVID-19 pandemic had long-term adverse effects on the mental health of health care workers. Indeed, PTSD symptoms have emerged as one of the significant mental health issues for health care workers arising from the COVID-19 pandemic. Therefore, we conducted this cross-sectional survey to investigate the prevalence of PTSD symptoms in health care workers and its relationship with the fear of COVID-19 and the COVID-19 burden after the full liberalization of COVID-19 prevention and control policy in China.

Methods
This study was conducted three years after the global COVID-19 pandemic (January 15 to January 16, 2023). This study was conducted via the Wenjuanxing platform and used the Chinese versions of the scales PC-PTSD-5, COVID-19 Anxiety Scale (FCV-19S), Social Support Scale, COVID-19 Stress Scale, GAD-2, and PHQ-2.

Results
The prevalence of PTSD symptoms in health care workers was 24.3% (232/955). depression(P < 0.001), anxiety(P < 0.05), the fear of COVID-19(P < 0.001), and COVID-19 burden(P < 0.001) were highly correlated with PTSD symptoms in health care workers. Social support(P < 0.05) was a protective factor of PTSD symptoms.

Conclusions
This survey shows that PTSD symptoms were highly prevalent among Chinese health care workers after the COVID-19 pandemic. Governments and leaders of medical institutions should, through psychological interventions, address the current situation of PTSD symptoms among health care workers and develop targeted programs and strategies to reduce their psychological problems.