bluuebunny/crossref_metadata_2025_split huggingface dataset:
LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy
Authors: Mai Sunny , Hodges Alan , Chen Hui-Ming , Zhang Jilu , Wang Yi-Ling , Liu Yongbin , Nakatsu Fumiko , Wang Xiaoxuan , Fang Jing , Xu Yitian , Davidov Vitaliy , Kang Kyeongah , Pingali Sai Ravi , Ganguly Siddhartha , Suzuki Masataka , Konopleva Marina , Prinzing Brooke , Zu Youli , Gottschalk Stephen , Lu Yong , Chen Shu-Hsia , Pan Ping-Ying 
Published: December 2023

Abstract

Identifying novel cell surface receptors that regulate leukemia cell differentiation and can be targeted to inhibit cellular proliferation is crucial to improve current treatment modalities in acute myeloid leukemia (AML), especially for relapsed or chemotherapy-refractory leukemia. Leukocyte immunoglobulin-like receptor type B (LILRB) is an immunomodulatory receptor originally found to be expressed in myeloid cells. In this study, we found that LILRB receptors can be induced under inflammatory stimuli and chemotherapy treatment conditions. Blockade of LILRB3 inhibited leukemia cell proliferation and leukemia progression. In addition, treatment with LILRB3 blocking antibodies upregulated myeloid lineage differentiation transcription factors, including PU.1, C/EBP family, and IRF, whereas phosphorylation of proliferation regulators, for example, AKT, cyclin D1, and retinoblastoma protein, was decreased. Conversely, transcriptomic analysis showed LILRB3 activation by agonist antibodies may enhance leukemia survival through upregulation of cholesterol metabolism, which has been shown to promote leukemia cell survival. Moreover, LILRB3-targeted CAR T cells exhibited potent antitumor effects both in vitro and in vivo. Taken together, our results suggest that LILRB3 is a potentially potent target for multiple treatment modalities in AML.

Significance:
LILRB3 regulates differentiation and proliferation in acute myeloid leukemia and can be targeted with monoclonal antibodies and CAR T cells to suppress leukemia growth.
Citron Kinase Is a Druggable Target in Treatment-Resistant Prostate Cancer
Authors: Mishra Rashmi , Blinka Steven , Hsieh Andrew C. 
Published: December 2023

AbstractProlonged treatment with androgen deprivation therapy (ADT) inevitably leads to castration-resistant prostate cancer (CRPC). Development of novel androgen-targeting agents and chemo/radiotherapies has resulted in improved survival. However, metastatic CRPC remains incurable. New therapeutics are greatly needed, and exploration of novel pathways such as the mechanisms underlying prostate cancer cell proliferation could potentially augment the natural course of CRPC. In the latest issue of Cancer Research, Rawat and colleagues delved deeply into the mechanistic role of citron kinase (CIT) in orchestrating prostate cancer proliferation and revealed its catalytic activity as a druggable target for treatment-resistant prostate cancer. The researchers utilized in vitro and in vivo methodologies to elucidate the function of CIT in mediating uncontrolled interphase progression and prostate cancer growth. Furthermore, the authors employed both androgen receptor–dependent and independent models to validate the significance of CIT kinase activity as a crucial factor in driving treatment-resistant prostate cancer growth. At a mechanistic level they determined that the E2F2-Skp2-p27 axis regulates CIT expression. Finally, they defined the landscape of CIT substrates in prostate cancer that encompasses a spectrum of cellular functions that spans key proliferation regulators to alternative splicing events. This comprehensive work provides insights into CIT as a potential biomarker for prostate cancer treatment resistance and disease progression and establishes the CIT kinase domain as a druggable target in CRPC.See related article by Rawat et al., p. 4142
Efficient Decoding of Large-Scale Neural Population Responses With Gaussian-Process Multiclass Regression
Authors: Greenidge C. Daniel , Scholl Benjamin , Yates Jacob L. , Pillow Jonathan W. 
Published: December 2023

Abstract
Neural decoding methods provide a powerful tool for quantifying the information content of neural population codes and the limits imposed by correlations in neural activity. However, standard decoding methods are prone to overfitting and scale poorly to high-dimensional settings. Here, we introduce a novel decoding method to overcome these limitations. Our approach, the gaussian process multiclass decoder (GPMD), is well suited to decoding a continuous low-dimensional variable from high-dimensional population activity and provides a platform for assessing the importance of correlations in neural population codes. The GPMD is a multinomial logistic regression model with a gaussian process prior over the decoding weights. The prior includes hyperparameters that govern the smoothness of each neuron’s decoding weights, allowing automatic pruning of uninformative neurons during inference. We provide a variational inference method for fitting the GPMD to data, which scales to hundreds or thousands of neurons and performs well even in data sets with more neurons than trials. We apply the GPMD to recordings from primary visual cortex in three species: monkey, ferret, and mouse. Our decoder achieves state-of-the-art accuracy on all three data sets and substantially outperforms independent Bayesian decoding, showing that knowledge of the correlation structure is essential for optimal decoding in all three species.
Emergence of Universal Computations Through Neural Manifold Dynamics
Authors: Gort Joan 
Published: December 2023

Abstract
There is growing evidence that many forms of neural computation may be implemented by low-dimensional dynamics unfolding at the population scale. However, neither the connectivity structure nor the general capabilities of these embedded dynamical processes are currently understood. In this work, the two most common formalisms of firing-rate models are evaluated using tools from analysis, topology, and nonlinear dynamics in order to provide plausible explanations for these problems. It is shown that low-rank structured connectivities predict the formation of invariant and globally attracting manifolds in all these models. Regarding the dynamics arising in these manifolds, it is proved they are topologically equivalent across the considered formalisms.
This letter also shows that under the low-rank hypothesis, the flows emerging in neural manifolds, including input-driven systems, are universal, which broadens previous findings. It explores how low-dimensional orbits can bear the production of continuous sets of muscular trajectories, the implementation of central pattern generators, and the storage of memory states. These dynamics can robustly simulate any Turing machine over arbitrary bounded memory strings, virtually endowing rate models with the power of universal computation. In addition, the letter shows how the low-rank hypothesis predicts the parsimonious correlation structure observed in cortical activity. Finally, it discusses how this theory could provide a useful tool from which to study neuropsychological phenomena using mathematical methods.
PaniniQA: Enhancing Patient Education Through Interactive Question Answering
Authors: Cai Pengshan , Yao Zonghai , Liu Fei , Wang Dakuo , Reilly Meghan , Zhou Huixue , Li Lingxi , Cao Yi , Kapoor Alok , Bajracharya Adarsha , Berlowitz Dan , Yu Hong 
Published: December 2023

Abstract
A patient portal allows discharged patients to access their personalized discharge instructions in electronic health records (EHRs). However, many patients have difficulty understanding or memorizing their discharge instructions (Zhao et al., 2017). In this paper, we present PaniniQA, a patient-centric interactive question answering system designed to help patients understand their discharge instructions. PaniniQA first identifies important clinical content from patients’ discharge instructions and then formulates patient-specific educational questions. In addition, PaniniQA is also equipped with answer verification functionality to provide timely feedback to correct patients’ misunderstandings. Our comprehensive automatic & human evaluation results demonstrate our PaniniQA is capable of improving patients’ mastery of their medical instructions through effective interactions.1
4Q37 and Excerpted Texts of Deuteronomy from Qumran
Authors: Dayfani Hila 
Published: December 2023

Abstract
Four manuscripts from Qumran Cave 4 are identified as manuscripts that constitute a collection of excerpts from Deuteronomy: 4Q37, 4Q38, 4Q41, and 4Q44. This paper focuses on 4Q37 and its contribution to understanding the larger group of Deuteronomy-excerpted texts. Based on material reconstruction of the scroll, the paper confirms that it originally included excerpts from both Deuteronomy and Exodus. This conclusion establishes the existence of a repertoire of scriptural sections that were selected and cited in special-use—probably liturgical—texts. The broader implications for the reception history of the Pentateuch in Second Temple times is that the Pentateuch was not conceptualized solely as a legal code or intellectual text but also as a text that was used in liturgy.
Reconsidering 4Q69 (4QpapIsap)
Authors: Gayer Asaf 
Published: December 2023

Abstract
4Q69 consists of two small papyrus fragments treating to Isa 5:28–30. Following Raffaella Cribiore’s criterion for identification of scribal exercises, an analysis of the textual variants to which the 4Q69 fragments attest will serve as a platform for exploring why the scribe(s) chose papyrus instead of parchment as his medium, the implications of the scroll’s column width, and the significance of its semi-cursive script and calligraphic traits. Engaging in a holistic assessment of the scroll’s purpose and use, this paper submits that rather than constituting a complete copy of the biblical book of Isaiah, it is a partial copy for use as a scribal exercise of a mid-level student. It thus sheds light on the educational process underlying the production of 4Q69 as the importance attached to the book of Isaiah during the Second Temple period and the book’s distinctive, authoritative status.
A new and a known species of Taeniastrotos Cressey, 1969 (Copepoda, Cyclopoida, Taeniacanthidae) parasitic on Japanese lizardfishes (Actinopterygii)
Authors: Izawa Kunihiko 
Published: December 2023

Abstract
Taeniastrotos tragus Dojiri & Cressey, 1987 is redescribed on the basis of specimens of both sexes recovered from Trachinocephalus myops (Forster, 1801), and T. synodi sp. nov. is described based on a single specimen of the female recovered from Synodus macrops Tanaka, 1917. The description of the male of T. tragus is the first for the species.
The effects of using different stocking volumes on the development of broodstocks of the blue crab, Callinectes sapidus Rathbun, 1896 (Brachyura, Portunidae)
Authors: Gencer Övgü 
Published: December 2023

Abstract
The aim of this study is to determine the effect of different stocking volumes on the survival and growth of broodstocks of the blue crab, Callinectes sapidus. Based on a Pearson correlation test, 0.70 litre tanks with three groups at different stocking densities (15, 10 and 5 individuals per tank) have been used in this study. The results show that the mortality rate due to cannibalism was high in the first test group, while it was found to be lower in the third group. There were significant differences in survival rates in the three different groups used in this trial of broodstock cultivation (). The higher the stocking densities, the lower the survival rates, i.e., significantly increasing the broodstock density reduces the survival rate.
Statistical differences have also been found in the development rates of broodstock crabs (), and it has been noted that there is slower development at higher stocking densities. If calculating the optimal stock density for mass production purposes is desired, less density thus appears to be more advantageous for both survival and growth rate.
Regulatory Choices at the Advent of Gig Warfare
Authors: Klamberg Mark 
Published: December 2023

Abstract
Regulation of military ai may take place in three ways. First, existing rules and principles in ihl is already or could be extended via reinterpretation to apply to military ai; second, new ai regulation may appear via “add-ons” to existing rules, finally, regulation of military ai may appear as a completely new framework, either through new state behavior that results in customary international law or through a new legal act or treaty. By introducing this typology, one may identify possible manners of regulation that are presently under-researched and/or ignored, for example how Rules of Engagement (roe) may be a way to control the use of military ai. Expanding on existing scholarship, the articles discusses how military ai may operate under different forms of military command and control systems, how regulation of military ai is not only a question of “means” but also “methods” of warfare and how the doctrine of supervisory responsibility may go beyond the doctrine of command responsibility. In the case that fully-automated Lethal Autonomous Weapons Systems (laws) are available and considered for use, it is suggested that their use should be prohibited in densely populated areas following the same logic as incendiary weapons. Further, one could introduce certain export restrictions on fully-automated laws to prevent proliferation to non-state actors and rogue states.
Hygienic indicator bacteria in the 2 species of wild-caught Japanese cicadas, large brown cicadas and robust cicadas
Authors: Ueda Takuro , Haga Bontetsu , Suzuki Hodaka 
Published: December 2023

Abstract
Entomophagy is considered a potent dietary practice to replace animal protein due to its highly nutritious and environmentally sustainable features. While entomophagy has many advantages, safety and security concerns still remain, especially for wild-caught insects, not farm-reared insects. This study aimed to clarify the potential microbiological hazards of eating wild-caught cicadas. Large brown cicadas and robust cicadas, which were commonly inhabited in Japan, were caught and examined the hygienic indicator bacteria, standard plate counts (SPC) and Enterobacteriaceae. Then, representative colonies of Enterobacteriaceae were identified. Also, the distribution of bacteria, i.e. the surface or inside the body of the cicadas, and the changes in the bacterial number during the storage of the dead cicadas were examined. SPC was in the range of 3.0 to 9.0 log CFU/g and Enterobacteriaceae was detected in the most of cicadas. Most of the Enterobacteriaceae species identified were biosafety level 2 pathogens or opportunistic pathogens. SPC and Enterobacteriaceae were distributed both on the surface and in the body of the cicadas. SPC and Enterobacteriaceae rapidly increased in the dead cicadas during the storage (at 25 °C). In this study, it is concluded that sufficient heat cooking and proper cold storage should be necessary for the safe consumption of cicadas as food.
Retention and excretion of microplastics by Yellow Mealworm (Tenebrio molitor) larvae reared on an amino formaldehyde polymer microbeads contaminated substrate
Authors: Randazzo B. , Uboni C. , Cardinaletti G. , Rondinella A. , Tulli F. 
Published: December 2023

Abstract
Yellow mealworm (Tenebrio molitor L., TM), one of the main cultured insect species, is used for feed and food. Larval stages of this species can be reared on several substrates, including grains and industrial by-products. However, this species may potentially accumulate contaminants from the substrate, including microplastics (MPs), which may represent a potential hazard for its utilization in food chain. Evidences for plastic degradation by mealworms have been reported, while there are few information about the retention of microplastics in the body and tissues of this species. The aim of the present study was to assess whether TM larvae reared on a MPs-contaminated substrate were able to retain MPs in body tissues and to evaluate the retention and excretion rate after fasting for 24 and 48 hours. For this purpose, fluorescent amino formaldehyde polymer microbeads (1-5 μm) were used to simulate a MPs contamination in the substrate used for larvae rearing. A relevant concentration of MPs were found in the gut and were associated with ingested feed. However, microscopic analyses indicated that the gut acts as a simple transit site and a barrier towards MPs migration in tissues. A marked reduction of MPS content was highlighted in larvae after fasting, even though a 48-hours fasting period was not sufficient to completely depurate insect gut from MPs. Results obtained in the present study suggest that the polymer microbeads used are recalcitrant to digestion by TM larvae, and show the relevant ability of depuration from MPs of this species. Taken together the results showed the suitability of TM to be reared on MPs contaminated substrates since larvae survival and growth resulted not hampered by the MPs presence and open cues on the fasting period able to completely depurate insect body from MPs residues.
Placement of Intracranial Pressure Monitors by Non-neurosurgeons: A Follow-Up Study
Authors: Jumpa Dania , Lightwine Kelly , Ablah Elizabeth , Okut Hayrettin , Grundmeyer Raymond , Haan James M. 
Published: December 2023

Background Some research suggests that physicians who are not neurosurgeons can safely place intracranial pressure (ICP) monitors. The purpose of this study was to compare intracranial pressure monitor placement complications between neurosurgeons, trauma physicians, and general surgery residents. We hypothesized that with appropriate training, general residents can safely place ICP monitors. Methods A 10-year retrospective chart review of all trauma patients that required ICP monitor placement between January 1, 2012, and December 31, 2021, was conducted. Comparisons were made between treatment groups. Results During the study period, 194 patients required ICP monitor placement. General surgery residents placed 94.3% of ICP monitors, 3.6% were placed by attending trauma physicians, and 2.1% by neurosurgeons. No ICP monitors were placed by attending trauma physicians or neurosurgeons between 2015 and 2018. Overall, minor complications during ICP monitor placement included device malfunction (2.7%) and inaccurate readings (.5%). There were no major complications during ICP monitor placement. Post-ICP monitor placement complications included one patient who experienced a central nervous system infection (.5%) and three patients who had mechanical problems (1.5%). No complications occurred among the neurosurgeon or attending trauma physician treatment groups. Conclusion Most intracranial pressure monitors in our study sample were safely placed by surgical residents. Based on our study findings and considering the shortage and downtrend of neurosurgery specialists, ICP bolt placement needs to become a core clinical skill in surgical resident programs across the United States.
The Funnel of Game Design – An Adaptive Game Design Approach for Complex Systems
Authors: Freese Maria , Lukosch Heide 
Published: December 2023

Background In a world of ever-increasing complexity, organizations and people have an ever-increasing need for support systems that help them understand and shape the world around them. While simulation game design derived from the very idea to propose an instrument able to address complexity, seminal approaches dealt with a different level of complexity. In a networked, digitalized world, complexity has increased, and traditional approaches towards designing games show certain shortcomings that have to be overcome. Aim This article proposes a new process of game design for complex problems and complex systems that can both be used by game designers as well as the scientific community in the field. This process is represented within a framework, based on two parts. The so-called ‘Funnel of Game Design’ based on the IDEAS approach represents the process of problem derivation, while the ‘House of Game Design’ also covers possible steps towards the final game product and process, including de-briefing and evaluation. Method Based on hands-on experiences and related work, we developed several steps of a game design process (IDEAS approach). In face-to-face interviews, we discussed the first version of the framework with experts in the field of simulation game studies. Results This process led to the framework presented in this article, which shows the steps of problem derivation as well as challenges that can occur, and proposes adaptive methods to overcome these challenges. The framework includes elements that support the definition of complex problems, and their translation into game designs. Recommendation We recommend practitioners and scientists to apply the new framework presented here in their efforts to define the underlying problem that should be addressed by an envisioned simulation game, and in translating this into a valid, engaging and meaningful game experience.
‘A lot of people think it’s just a Mickey Mouse role’: Role ambiguity among dementia support workers within secondary care and community hospital settings
Authors: Prendergast Louise Margaret , Davies Ceryl Teleri , Williamson Tracey 
Published: December 2023

Purpose: Dementia support workers (DSWs) are employed to improve the hospital care for patients living with dementia. An evaluation sought to understand the perspectives and experiences of DSWs and related healthcare practitioners within one health board, to identify any role ambiguity and inform future role development. Design/methodology/approach: Framework analysis was used to synthesise data from semi-structured interviews and focus groups with dementia support workers, and a wider group of related healthcare practitioners. Findings: Thirteen semi-structured interviews were conducted with DSWs. Two focus groups were held with DSWs ( n = 2 and 4) and two with associated healthcare practitioners ( n = 3 and 5). Participants described inconsistencies in the understanding and delivery of the DSW role. Role ambiguity was identified as a key theme. Originality/value: This paper offers insight into challenges experienced by DSWs and addresses factors that could help improve and support the DSW role, and potentially the experience of other staff, and patients/people living with dementia. Overall, this evaluation highlights both the value of the DSW role in supporting the needs of patients/people living with dementia and the potential for person-centred activities to be used as therapeutic interventions.