bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the association between mothers’ autistic traits and childhood autistic traits moderated by maternal pre-pregnancy body mass index?
Authors: Sari Novika Purnama , Tsompanidis Alexandros , Wahab Rama J. , Gaillard Romy , Aydin Ezra , Holt Rosemary , Allison Carrie , Baron-Cohen Simon , van IJzendoorn Marinus H. , Jansen Pauline W. 
Published: December 2023

Abstract
Background
Previous studies showed that there is a positive association between mothers’ and children’s autistic traits. We also tested if this association is more pronounced in mothers with a higher pre-pregnancy body mass index (BMI).

Method
The study was embedded in two cohorts with information available for 4,659 participants from the Generation R and for 179 participants from the Cambridge Ultrasound Siblings and Parents Project (CUSP) cohort. In both cohorts, maternal autistic traits were assessed using the short form of the Autism Spectrum Quotient, and information about maternal height and weight before pregnancy was obtained by questionnaire. Child autistic traits were assessed with the short form of Social Responsiveness Scale in Generation R (M = 13.5 years) and with the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in the CUSP cohort (M = 1.6 years).

Result
Higher maternal autistic traits were associated with higher autistic traits in toddlerhood (CUSP cohort; βadjusted = 0.20, p < 0.01), in early childhood (Generation R; βadjusted = 0.19, p < 0.01), and in early adolescence (Generation R; βadjusted = 0.16, p < 0.01). Furthermore, a higher maternal pre-pregnancy BMI was associated with higher child autistic traits, but only in Generation R (βadjusted = 0.03, p < 0.01). There was no significant moderating effect of maternal pre-pregnancy BMI on the association between autistic traits of mothers and children, neither in Generation R nor in CUSP. In addition, child autistic traits scores were significantly higher in mothers who were underweight and in mothers who were overweight compared to mothers with a healthy weight.

Conclusion
We confirm the association between maternal and child autistic traits in toddlerhood, early childhood, and early adolescence. Potential interacting neurobiological processes remain to be confirmed.
High-grade HER2-positive mucoepidermoid carcinoma of the breast: a case report and review of the literature
Authors: Mura Mario Della , Clement Céline , Foschini Maria P. , Vander Borght Sara , Waumans Lise , Van Eyken Peter , Hauben Esther , Keupers Machteld , Weltens Caroline , Smeets Ann , Nevelsteen Ines , Floris Giuseppe 
Published: December 2023

Abstract
Background
Mucoepidermoid carcinoma of the breast is a rare special type of salivary gland-like tumor of the breast, usually displaying triple-negative phenotype. To date, only 64 cases have been reported in the English literature. Herein, we report the first case of mucoepidermoid carcinoma of the breast with human epidermal growth factor receptor 2 gene amplification.

Case presentation
A 58-year-old Caucasian woman treated with breast-conserving surgery, radiotherapy, and chemotherapy for an invasive breast carcinoma of no special type, relapsed 20 years later in the ipsilateral left breast. Histological examination of the core needle biopsy of the relapse deferred to the surgical specimen for the definitive diagnosis, because of the broad differential diagnosis. On the resected specimen we observed the presence of a poorly differentiated carcinoma with mucoepidermoid carcinoma of the breast typical features consisting of epidermoid, intermediate and mucinous cells lacking true keratinization, in keeping with the latest World Health Organization diagnostic criteria. The mucoepidermoid carcinoma of the breast was weakly estrogen receptor and androgen receptor positive and progesterone receptor negative, but exceptionally showed human epidermal growth factor receptor 2 gene amplification. Mastermind-like transcriptional coactivator 2 gene translocations were not detected by fluorescent in situ hybridization. The patient received adjuvant chemotherapy with anti-human epidermal growth factor receptor 2 therapy but no endocrine therapy. After 61 months of follow-up, no signs of local or distant recurrence were observed.

Conclusions
Mucoepidermoid carcinoma of the breast is a very rare entity. Despite being most frequently triple negative, the standard evaluation of receptor status is mandatory, as well as strict application of World Health Organization diagnostic criteria for correct patient management.
Antibiotic-loaded spacer arthroplasty in a terrible triad injury with unreconstructable radial head fracture: a case report
Authors: Barati Hasan , Baroutkoub Mojtaba , Zabeti Targhi Nikaein , Beheshti Fard Shahabaldin , Hajikarimloo Bardia , Afzal Sina 
Published: December 2023

Abstract
Background
Radial head arthroplasty is a viable option in cases with terrible triad injuries of elbow, wherein the radial head sustains significant comminution that precludes reconstruction. Nevertheless, this alternative is not recommended for individuals with poor elbow skin conditions, accompanied neuropsychiatric disorders, or low patient compliance. This case report presents a patient with bilateral terrible triad injury, along with the aforementioned conditions. The report outlines the treatment challenges of such a case and proposes potential solutions.

Case presentation
A 37-year-old Persian male patient presenting with a bilateral terrible triad fracture–dislocation and a history of psychoactive substance abuse, was admitted to our emergency department. The patient underwent radial head replacement using a cement spacer containing antibiotics, due to the comminuted radial head in the presence of a contaminated wound on the left elbow. The fracture of the right side was successfully fixed. Subsequent to discharge, the patient did not attend any follow-up appointments. After a period of 6 months, he was admitted to the psychiatric ward and orthopedic consultation was requested to evaluate the patient.

Conclusion
In acute terrible triad injuries with unreconstructable radial head fractures where arthroplasty with metallic prostheses may not be suitable due to contaminated wounds, unstable psychiatric condition, and low patient cooperation, temporary orthopedic cement spacers can maintain elbow biomechanics, stability, and sterility.
HybridGCN for protein solubility prediction with adaptive weighting of multiple features
Authors: Chen Long , Wu Rining , Zhou Feixiang , Zhang Huifeng , Liu Jian K. 
Published: December 2023

AbstractThe solubility of proteins stands as a pivotal factor in the realm of pharmaceutical research and production. Addressing the imperative to enhance production efficiency and curtail experimental costs, the demand arises for computational models adept at accurately predicting solubility based on provided datasets. Prior investigations have leveraged deep learning models and feature engineering techniques to distill features from raw protein sequences for solubility prediction. However, these methodologies have not thoroughly delved into the interdependencies among features or their respective magnitudes of significance. This study introduces HybridGCN, a pioneering Hybrid Graph Convolutional Network that elevates solubility prediction accuracy through the combination of diverse features, encompassing sophisticated deep-learning features and classical biophysical features. An exploration into the intricate interplay between deep-learning features and biophysical features revealed that specific biophysical attributes, notably evolutionary features, complement features extracted by advanced deep-learning models. Augmenting the model’s capability for feature representation, we employed ESM, a substantial protein language model, to derive a zero-shot learning feature capturing comprehensive and pertinent information concerning protein functions and structures. Furthermore, we proposed a novel feature fusion module termed Adaptive Feature Re-weighting (AFR) to integrate multiple features, thereby enabling the fine-tuning of feature importance. Ablation experiments and comparative analyses attest to the efficacy of the HybridGCN approach, culminating in state-of-the-art performances on the public eSOL and S. cerevisiae datasets.
Independently convolutional gated recurrent neural unit for space-based ADS-B signal separation with single antenna
Authors: Li Chuankun , Bi Yan 
Published: December 2023

AbstractAutomatic Dependent Surveillance-Broadcast (ADS-B) is a critical technology to transform aircraft navigation by improving safety and overall effectiveness in the aviation industry. However, overlapping of ADS-B signals is a large challenge, especially for space-based ADS-B systems. Existing traditional methods are not effective when dealing with cases that overlapped signals with small difference (such as power difference and carrier frequency difference) require to be separated. In order to generate an effective separation performance of the ADS-B signals by exploring its temporal relationship, Independently Convolutional Gated Recurrent Neural Unit (Ind-CGRU) is presented for encoder–decoder network construction. Experimental results on the dataset SR-ADSB demonstrate that the proposed Ind-CGRU achieves good performance.
Existence and multiplicity of solutions for boundary value problem of singular two-term fractional differential equation with delay and sign-changing nonlinearity
Authors: Bai Rulan , Zhang Kemei , Xie Xue-Jun 
Published: December 2023

AbstractIn this paper, we consider the existence of solutions for a boundary value problem of singular two-term fractional differential equation with delay and sign-changing nonlinearity. By means of the Guo–Krasnosel’skii fixed point theorem and the Leray–Schauder nonlinear alternative theorem, we obtain some results on the existence and multiplicity of solutions, respectively.
Rich dynamics of a delayed SIRS epidemic model with two-age structure and logistic growth
Authors: Yan Dongxue , Cao Yu 
Published: December 2023

AbstractThis paper studies a two-age structured SIRS epidemic model with logistic growth of susceptible population and two-time delays. We simultaneously introduce two-time delays, i.e., the immunity and incubation periods, into this dynamic system and investigate their impact on different dynamic behaviors for the model. By means of the $C_{0}$

C
0

-semigroup theory, the model is transformed into a non-densely defined abstract Cauchy problem, and the condition of the existence and uniqueness of the endemic equilibrium is obtained. Following the spectral analysis, the characteristic equation technique, and the Hopf bifurcation theorem, we show that different combinations of the two delays perform a vital role in the instability/stability as well as the Hopf bifurcation results of equilibrium solutions. We numerically provide some graphical representations to check the main theoretical results and show the rich dynamics by varying the two delay parameters.
Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms
Authors: Vázquez-Borrego Mari C. , Granados-Rodríguez Melissa , Bura Florina I. , Martínez-López Ana , Rufián-Andújar Blanca , Valenzuela-Molina Francisca , Rodríguez-Ortiz Lidia , Haro-Yuste Sergio , Moreno-Serrano Ana , Ortega-Salas Rosa , Pineda-Reyes Rafael , Michán Carmen , Alhama José , Romero-Ruiz Antonio , Arjona-Sánchez Álvaro 
Published: December 2023

AbstractPseudomyxoma peritonei (PMP) is a rare disease characterized by a massive accumulation of mucus in the peritoneal cavity. The only effective treatment is aggressive surgery, aimed at removing all visible tumors. However, a high percentage of patients relapse, with subsequent progression and death. Recently, there has been an increase in therapies that target mutated oncogenic proteins. In this sense, KRAS has been reported to be highly mutated in PMP, with KRASG12D being the most common subtype. Here, we tested the efficacy of a small-molecule KRASG12D inhibitor, MRTX1133, in a high-grade PMP xenograft mouse model carrying a KRASG12D mutation. The results obtained in this work showed a profound inhibition of tumor growth, which was associated with a reduction in cell proliferation, an increase in apoptosis, and a reduction in the MAPK and PI3K/AKT/mTOR signaling pathways. In conclusion, these results demonstrate the high potency and efficacy of MRTX1133 in KRASG12D-PMP tumors and provide a rationale for clinical trials.
Two novel deletion mutations in β-globin gene cause β-thalassemia trait in two Chinese families
Authors: Bao Xiuqin , Qin Danqing , Wang Jicheng , Chen Jing , Yao Cuize , Liang Jie , Liang Kailing , Wang Yixia , Wang Yousheng , Du Li , Yin Aihua 
Published: December 2023

Abstract
Background
β-Thalassemia is mainly caused by point mutations in the β-globin gene cluster. With the rapid development of sequencing technic, more and more variants are being discovered.

Results
In this study, we found two novel deletion mutations in two unrelated families, HBB: c.180delG (termed βCD59) and HBB: c.382_402delCAGGCTGCCTATCAGAAAGTG (termed βCD128-134) in family A and B, respectively. Both the two novel mutations lead to β-thalassemia trait. However, when compounded with other β0-thalassemia, it may behave with β-thalassemia intermedia or β-thalassemia major.

Conclusion
Our study broadens the variants spectral of β-thalassemia in Chinese population and provides theoretical guidance for the prenatal diagnosis.
The coverage and challenges of increasing uptake of non-National Immunization Program vaccines in China: a scoping review
Authors: Jiang Mingzhu , Chen Shu , Yan Xuanxuan , Ying Xiaohua , Tang Shenglan 
Published: December 2023

AbstractBackgroundNon-National Immunization Program (NIP) vaccines have played an important role in controlling vaccine-preventable diseases (VPDs) in China. However, these vaccines are paid out of pocket and there is room to increase their coverage. We focused on four selected non-NIP vaccines in this study, namelyHaemophilus influenzaetype b (Hib) vaccine, human papillomavirus (HPV) vaccine, pneumococcal conjugate vaccine (PCV), and rotavirus vaccine. We aimed to conduct a scoping review of their vaccination rates and the major barriers faced by health systems, providers, and caregivers to increase coverage.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). We searched five English databases (PubMed, Web of Science, EMBASE, Scopus, and WHO IRIS) and four Chinese databases using the search strategy developed by the study team. Two independent reviewers screened, selected studies, and examined their quality. We summarized the non-NIP vaccine coverage data by vaccine and applied the 5A framework (Access, Affordability, Acceptance, Awareness, Activation) to chart and analyze barriers to increasing coverage.ResultsA total of 28 articles were included in the analysis (nine pertaining to vaccine coverage, and another 19 reporting challenges of increasing uptake). Among the four selected vaccines, coverage for the Hib vaccine was the highest (54.9–55.9% for 1 dose or more from two meta-analyses) in 2016, while the coverage of the other three vaccines was lower than 30%. Eight of the nine included articles mentioned the regional disparity of coverage, which was lower in under-developing regions. For example, the three-dose Hib vaccination rate in eastern provinces was 38.1%, whereas the rate in central and western provinces was 34.3% and 26.2%, respectively in 2017. Within the 5A framework, acceptance, awareness, and affordability stood out as the most prominent themes. Among the 12 identified sub-themes, high prices, low vaccine awareness, concerns about vaccine safety and efficacy were the most cited barriers to increasing the uptake.ConclusionsThere is an urgent need to increase coverage of non-NIP vaccines and reduce disparities in access to these vaccines across regions. Concerted efforts from the government, the public, and society are required to tackle the barriers and challenges identified in this study, both on the demand and supply side, to ensure everybody has equal access to life-saving vaccines in China. Particularly, the government should take a prudent approach to gradually incorporate non-NIP vaccines into the NIP step by step, and make a prioritizing strategy based on key factors such as disease burden, financial resources, and market readiness, with special attention to high-risk populations and underdeveloped regions.Graphical Abstract
Validation of a Latin-American Spanish version of the Body Esteem Scale for Adolescents and Adults (BESAA-LA) in Colombian and Nicaraguan adults
Authors: Andres Fabienne E. , Thornborrow Tracey , Bowie Wienis N. , Chamorro Ana Maria , De la Rosa Gisell , Evans Elizabeth H. , Fontalvo Acuña Laura S. , Kolar David R. , Mebarak Moises R. , Tovar Castro Juan Camilo , Boothroyd Lynda G. 
Published: December 2023

Abstract
Background
Body dissatisfaction (BD) is a growing concern in Latin America; reliable and culturally appropriate scales are necessary to support body image research in Spanish speaking Latin American countries. We sought to validate a Latin-American Spanish version of the Body Esteem Scale for Adolescents and Adults (BESAA; Mendelson et al. 2001).

Methods
The BESAA was translated, culturally adapted, and validated in a sample of adults in Colombia (N = 525, 65% women, Mage 24.4, SD = 9.28). We assessed factor structure (using confirmatory factor analysis (CFA), exploratory factor analysis (EFA) and exploratory structural equation model (ESEM)), internal reliability (using Cronbach’s alpha and omega), validity (using the Body Appreciation Scale BAS and Sociocultural Attitudes Towards Appearance Questionnaire SATAQ), test–retest stability in a small subsample (N = 84, using Intraclass correlations ICC) and measurement invariance across gender. To evaluate the generalizability of the scale, we assessed reliability, validity, and factor structure in a second sample from rural Nicaragua (N = 102, 73% women, Mage 22.2, SD = 4.72), and assessed measurement invariance across Nicaraguan and Colombian participants.

Results
The scale showed good internal reliability and validity in both samples, and there was evidence of adequate test–retest stability in the Colombian sample. EFA showed a three-factor structure with subscales we labelled ‘appearance-positive’, ‘appearance-negative’ and ‘weight’, that was confirmed using CFA and ESEM in the Colombian sample. Measurement invariance was confirmed across the Colombian and Nicaraguan samples, and across gender within the Colombian sample.

Conclusion
The Latin-American Spanish version of the BESAA (BESAA-LA) appears to be a psychometrically sound measure with good reliability, validity and invariance across gender and countries. These results support the use of this scale to measure body satisfaction/dissatisfaction in Latin American adult populations.
Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial
Authors: Notz Quirin , Heyland Daren K. , Lee Zheng-Yii , Menger Johannes , Herrmann Johannes , Chillon Thilo S. , Fremes Stephen , Mohammadi Siamak , Elke Gunnar , Mazer C. David , Hill Aileen , Velten Markus , Ott Sascha , Kleine-Brueggeney Maren , Meybohm Patrick , Schomburg Lutz , Stoppe Christian 
Published: December 2023

Abstract
Background
Recent data from the randomized SUSTAIN CSX trial could not confirm clinical benefits from perioperative selenium treatment in high-risk cardiac surgery patients. Underlying reasons may involve inadequate biosynthesis of glutathione peroxidase (GPx3), which is a key mediator of selenium's antioxidant effects. This secondary analysis aimed to identify patients with an increase in GPx3 activity following selenium treatment. We hypothesize that these responders might benefit from perioperative selenium treatment.

Methods
Patients were selected based on the availability of selenium biomarker information. Four subgroups were defined according to the patient's baseline status, including those with normal kidney function, reduced kidney function, selenium deficiency, and submaximal GPx3 activity.

Results
Two hundred and forty-four patients were included in this analysis. Overall, higher serum concentrations of selenium, selenoprotein P (SELENOP) and GPx3 were correlated with less organ injury. GPx3 activity at baseline was predictive of 6-month survival (AUC 0.73; p = 0.03). While selenium treatment elevated serum selenium and SELENOP concentrations but not GPx3 activity in the full patient cohort, subgroup analyses revealed that GPx3 activity increased in patients with reduced kidney function, selenium deficiency and low to moderate GPx3 activity. Clinical outcomes did not vary between selenium treatment and placebo in any of these subgroups, though the study was not powered to conclusively detect differences in outcomes.

Conclusions
The identification of GPx3 responders encourages further refined investigations into the treatment effects of selenium in high-risk cardiac surgery patients.

Graphical Abstract
Clinical application of a population-based input function (PBIF) for a shortened dynamic whole-body FDG-PET/CT protocol in patients with metastatic melanoma treated by immunotherapy
Authors: Pavoine Mathieu , Thuillier Philippe , Karakatsanis Nicolas , Legoupil Delphine , Amrane Karim , Floch Romain , Le Pennec Romain , Salaün Pierre-Yves , Abgral Ronan , Bourhis David 
Published: December 2023

Abstract
Background
The aim was to investigate the feasibility of a shortened dynamic whole-body (dWB) FDG-PET/CT protocol and Patlak imaging using a population-based input function (PBIF), instead of an image-derived input function (IDIF) across the 60-min post-injection period, and study its effect on the FDG influx rate (Ki) quantification in patients with metastatic melanoma (MM) undergoing immunotherapy.

Methods
Thirty-seven patients were enrolled, including a PBIF modeling group (n = 17) and an independent validation cohort (n = 20) of MM from the ongoing prospective IMMUNOPET2 trial. All dWB-PET data were acquired on Vision 600 PET/CT systems. The PBIF was fitted using a Feng’s 4-compartments model and scaled to the individual IDIF tail’s section within the shortened acquisition time. The area under the curve (AUC) of PBIFs was compared to respective IDIFs AUC within 9 shortened time windows (TW) in terms of linear correlation (R2) and Bland–Altman tests. Ki metrics calculated with PBIF vs IDIF on 8 organs with physiological tracer uptake, 44 tumoral lesions of MM and 11 immune-induced inflammatory sites of pseudo-progression disease were also compared (Mann–Whitney test).

Results
The mean ± SD relative AUC bias was calculated at 0.5 ± 3.8% (R2 = 0.961, AUCPBIF = 1.007 × AUCIDIF). In terms of optimal use in routine practice and statistical results, the 5th–7th pass (R2 = 0.999 for both Ki mean and Ki max) and 5th–8th pass (mean ± SD bias = − 4.9 ± 6.5% for Ki mean and − 4.8% ± 5.6% for Ki max) windows were selected. There was no significant difference in Ki values from PBIF5_7 vs IDIF5_7 for physiological uptakes (p > 0.05) as well as for tumor lesions (mean ± SD Ki IDIF5_7 3.07 ± 3.27 vs Ki PBIF5_7 2.86 ± 2.96 100ml/ml/min, p = 0.586) and for inflammatory sites (mean ± SD Ki IDIF5_7 1.13 ± 0.59 vs Ki PBIF5_7 1.13 ± 0.55 100ml/ml/min, p = 0.98).

Conclusion
Our study showed the feasibility of a shortened dWB-PET imaging protocol with a PBIF approach, allowing to reduce acquisition duration from 70 to 20 min with reasonable bias. These findings open perspectives for its clinical use in routine practice such as treatment response assessment in oncology.