bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring ventral tail base surface temperature for fever detection in calves
Authors: Ozawa Tomomi , Takahashi Yuji , Muneta Yoshihiro , Hoshinoo Kaori , Kimura Kumiko , Tou Seijiro , Kakihara Shin , Yamanaka Noriko , Miyamoto Toru , Higaki Shogo , Yoshioka Koji 
Published: February 2024

AbstractIn this study, we investigated whether monitoring the ventral tail base surface temperature (ST) using a wearable wireless sensor could be effective for fever detection in calves with experimentally induced pneumonia after inoculation with Histophilus somni strain 2336. We found a significant difference in the changes in ST values between the control and H. somni‐inoculated groups after 24 h of inoculation and detected fever; however, the rectal temperature showed a significant difference between the groups after 12 h of inoculation. When a significant difference in the ST between the two groups was observed, serum haptoglobin concentration and exacerbation of clinical score increased in the H. somni‐inoculated group compared with those in the control group. Pneumonia was observed in the H. somni‐inoculated group at necropsy, indicating that the changes in ST may reflect fever with inflammation caused by H. somni infection. Our results demonstrated that monitoring ST using a sensor attached to the ventral tail base can detect fever in calves and may be a useful and labor‐saving tool for the health management of calves.
Development of a therapeutic drug‐monitoring algorithm for outpatients receiving voriconazole: A multicentre retrospective study
Authors: Kato Hideo , Umemura Takumi , Hagihara Mao , Shiota Arifumi , Asai Nobuhiro , Hamada Yukihiro , Mikamo Hiroshige , Iwamoto Takuya 
Published: February 2024

AbstractAimsAlthough therapeutic drug monitoring (TDM) of voriconazole is performed in outpatients to prevent treatment failure and toxicity, whether TDM should be performed in all or only selected patients remains controversial. This study evaluated the association between voriconazole trough concentrations and clinical events.MethodsWe investigated the aggravation of clinical symptoms, incidence of hepatotoxicity and visual disturbances, change in co‐medications and interaction between voriconazole and co‐medications in outpatients receiving voriconazole between 2017 and 2021 in three facilities. Abnormal trough concentrations were defined as <1.0 mg/L (low group) and >4.0 mg/L (high group).ResultsA total of 141 outpatients (578 concentration measurements) met the inclusion criteria (treatment, 37 patients, 131 values; prophylaxis, 104 patients, 447 values). The percentages of patients with abnormal concentrations were 29.0% and 31.5% in the treatment and prophylaxis groups, respectively. Abnormal concentrations showed 50% of the concentrations at the first measurement in both therapies. Aggravation of clinical symptoms was most frequently observed in the low treatment group (18.2%). Adverse events were most common in the high group for both therapies (treatment, hepatotoxicity 6.3%, visual disturbance 18.8%; prophylaxis, hepatotoxicity 27.9%). No differences were found in changes to co‐medications and drug interactions. In the prophylaxis group, prescription duration in the presence of clinical events tended to be longer than in their absence (47.4 ± 23.4 days vs 39.7 ± 21.9 days, P = .1132).ConclusionsWe developed an algorithm based on clinical events for appropriate implementation of TDM in outpatients. However, future interventions based on this algorithm should be validated.
Appropriateness of direct oral anticoagulant prescribing in older subjects with atrial fibrillation discharged from acute medical wards
Authors: De Vincentis Antonio , Soraci Luca , Arena Elena , Sciacqua Angela , Armentaro Giuseppe , Aucella Francesco , Corsonello Andrea , Aucella Filippo , Antonelli Incalzi Raffaele 
Published: February 2024

AbstractAimsKnowledge on the prescriptive practice of direct oral anticoagulants (DOACs) in older subjects with atrial fibrillation (AF) hospitalized in acute medical wards is limited. This study aimed to evaluate the prevalence and appropriateness of DOAC prescriptions in hospitalized older subjects with AF, discharged from acute medical wards.MethodsWe analysed a cohort of 609 subjects with AF, aged ≥65 years (mean age 85 years) enrolled from 39 geriatric and nephrology wards in Italy. DOAC prescriptive appropriateness was evaluated according to the summary of product characteristics (smPC), 2019 Beers and STOPP criteria, and drug–drug interactions (DDIs).ResultsAt hospital discharge, 33% of patients with AF were prescribed with DOAC, 26% with vitamin‐K antagonist, while 41% did not receive any anticoagulant. Among subjects on DOAC therapy, 31% presented a violation of the smPC criteria (mainly underdosage—17%), while 48% and 18% presented a Beers/STOPP inappropriate prescription, or a DDI, respectively. Older age, lower body mass index (BMI), cancer and higher estimated glomerular filtration rate (eGFR) were independently associated with DOAC underdosage or missed prescription (age: adjusted odds ratio [aOR] 1.06, 95% confidence interval [95% CI] 1.00–1.12 for underdosage; eGFR: aOR 1.04, 95% CI 1.02–1.07 for underdosage; BMI: aOR 0.95, 95% CI 0.91–0.99 for missed prescription; cancer: aOR 1.93, 95% CI 1.19–3.13 for missed prescription).ConclusionsThis study showed a suboptimal DOAC prescriptive practice in older in‐patients, with frequent missed prescription and DOAC underdosage. Contrary to current recommendations, physicians appear overly concerned by bleeding risk in real‐life older and frailer subjects. Strategies should be developed to promote appropriate DOAC prescription in the hospital setting.
Validating methods used to identify non‐adherence adverse drug events in Canadian administrative health data
Authors: Wickham Maeve E. , McGrail Kimberlyn M. , Law Michael R. , Cragg Amber , Hohl Corinne M. 
Published: February 2024

AbstractAimsMedication non‐adherence is a type of adverse drug event that can lead to untreated and exacerbated chronic illness, and that drives healthcare utilization. Research using medication claims data has attempted to identify instances of medication non‐adherence using the proportion of days covered or by examining gaps between medication refills. We sought to validate these measures compared to a gold standard diagnosis of non‐adherence made in hospital.MethodsThis was a retrospective analysis of adverse drug events diagnosed during three prospective cohorts in British Columbia between 2008 and 2015 (n = 976). We linked prospectively identified adverse drug events to medication claims data to examine the sensitivity and specificity of typical non‐adherence measures.ResultsThe sensitivity of the non‐adherence measures ranged from 22.4% to 37.5%, with a proportion of days covered threshold of 95% performing the best; the non‐persistence measures had sensitivities ranging from 10.4% to 58.3%. While a 7‐day gap was most sensitive, it classified 61.2% of the sample as non‐adherent, whereas only 19.6% were diagnosed as such in hospital.ConclusionsThe methods used to identify non‐adherence in administrative databases are not accurate when compared to a gold standard diagnosis by healthcare providers. Research that has relied on administrative data to identify non‐adherent patients both underestimates the magnitude of the problem and may label patients as non‐adherent who were in fact adherent.
Patient preferences in the treatment of stage III/IV classic Hodgkin lymphoma: Results from the CONNECT cross‐sectional survey
Authors: Flora Darcy R. , Parsons Susan K. , Liu Nicholas , Yu Kristina S. , Holmes Katherine , Flores Carlos , Fanale Michelle A. , Surinach Andy , Byrd Rachel , Evens Andrew M. 
Published: February 2024

SummaryWe explored patient front‐line treatment preferences in newly diagnosed stage III/IV classic Hodgkin lymphoma (cHL). The CONNECT patient survey, administered online from 30 December 2020 to 1 March 2021, examined preferences overall and by age at diagnosis in 182 adult patients diagnosed with stage III/IV cHL within the past 10 years in the United States. At diagnosis, patients' median age was 36 years; 66% of patients were younger (aged 16–41 years) and 34% older (aged 42–85 years). When asked about initial treatment goals, 74% of patients ranked cure as their first or second goal (86% younger vs. 52% older patients; p < 0.001). At diagnosis, 72% of patients preferred aggressive treatment, and 85% were willing to accept more short‐term risks in exchange for a better‐working therapy long term. For long‐term risks, younger versus older patients were significantly more concerned about second cancers (p < 0.001) and fertility issues (p = 0.007), whereas older patients were more concerned about lung damage (p = 0.028) and infections (p < 0.001). Most patients (94%) reported having a caregiver at some point, but 99% of these patients retained some control of treatment decisions. Collectively, these survey results highlight patient treatment preferences and differences in treatment goals and long‐term side effect concerns based on patient age.
Thrombotic and bleeding complications in patients with AL amyloidosis
Authors: Fotiou Despina , Theodorakakou Foteini , Spiliopoulou Sotiria , Gavriatopoulou Maria , Migkou Magdalini , Kanellias Nikolaos , Eleutherakis‐Papaiakovou Evangelos , Malandrakis Panagiotis , Dialoupi Ioanna , Roussou Maria , Ntanasis‐Stathopoulos Ioannis , Terpos Evangelos , Dimopoulos Meletios A. , Kastritis Efstathios 
Published: February 2024

SummaryHaemostatic abnormalities and deregulated coagulation are common complications in AL amyloidosis. The relevant risks of thromboembolic and haemorrhagic events have not been thoroughly evaluated. To describe clinically significant thrombotic/haemorrhagic events in 450 consecutive patients with AL amyloidosis. Venous thromboembolic events (VTEs) were reported in 6% and arterial embolic events (AEEs) in 5% of patients, respectively, during a 55‐month median follow‐up. Lower albumin, lower eGFR, higher BM infiltration, soft tissue involvement, IMiD‐based therapy and prior thrombosis were associated with VTE risk. Prior thrombosis was the only independent prognostic variable (HR 9.3, p = 0.001). Coronary arterial disease, prior AEE, 24‐h proteinuria and higher platelet counts were associated with AEE risk. Significant bleeding events were reported in 9%, and associated mortality was 19%. Liver involvement, higher serum creatinine and higher baseline VWF:Ag levels were linked to bleeding risk. Using competing risk analysis, the cumulative probability of thrombosis/bleeding was higher during the first year following diagnosis, but a stable lower risk for both events remained for the duration of follow‐up. In AL amyloidosis patients, the risk of thrombotic/arterial embolic events is significant, but the bleeding risk is also high. A multiparametric assessment is required to initiate anti‐thrombotic or anti‐platelet therapy appropriately.
Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT2A and 5‐HT1A receptors
Authors: Werle Isabel , Nascimento Laura M. M. , dos Santos Aymee L. A. , Soares Luciane A. , dos Santos Rafael G. , Hallak Jaime E. C. , Bertoglio Leandro J. 
Published: February 2024

AbstractBackground and PurposeAyahuasca (AYA) is a botanical psychedelic with promising results in observational and small clinical trials for depression, trauma and drug use disorders. Its psychoactive effects primarily stem from N,N‐dimethyltryptamine (DMT). However, there is a lack of research on how and where AYA acts in the brain. This study addressed these questions by examining the extinction of aversive memories in AYA‐treated rats.Experimental ApproachWe focused on the 5‐HT1A and 5‐HT2A receptors, as DMT exhibits a high affinity for both of them, along with the infralimbic cortex in which activity and plasticity play crucial roles in regulating the mnemonic process under analysis.Key ResultsA single oral treatment with AYA containing 0.3 mg·kg−1 of DMT increased the within‐session extinction of contextual freezing behaviour without affecting its recall. This protocol, when repeated twice on consecutive days, enhanced extinction recall. These effects were consistent for both 1‐ and 21‐day‐old memories in males and females. AYA effects on fear extinction were independent of changes in anxiety and general exploratory activity: AYA‐ and vehicle‐treated animals showed no differences when tested in the elevated plus‐maze. The 5‐HT2A receptor antagonist MDL‐11,939 and the 5‐HT1A receptor antagonist WAY‐100635 infused into the infralimbic cortex respectively blocked within‐ and between‐session fear extinction effects resulting from repeated oral administration of AYA.Conclusion and ImplicationsOur findings highlight complementary mechanisms by which AYA facilitates the behavioural suppression of aversive memories in the rat infralimbic cortex. These results suggest potential beneficial effects of AYA or DMT in stress‐related disorders.
Antifascist praxis in developmental science: Possibilities for collective resistance to fascism
Authors: Arbeit Miriam R. , Negrete Andrea , Berger Natasha Panlilio , Dufault Anne E. , Onuoha Alexandria C. , Burnham Sarah L. F. 
Published: February 2024

AbstractAntifascists have developed action‐oriented principles and practices for collective resistance to fascism. In this article, we discuss antifascism as praxis, which is the nexus of theory and practice through collective reflection and action. Antifascist praxis can inform developmental science at individual and contextual levels of analysis. For the study of individual developmental trajectories, we examine how antifascist praxis can inform research to stop fascist recruitment of youth and counter‐recruit youth into liberation movements. For the study of developmental contexts, we use the example of family separation to examine how antifascist praxis can inform research to identify fascist threats and support collective action against fascist violence. We also present next steps for developing a field of scholarship in which communities of developmental scientists engage in antifascist praxis. As developmental scientists, we must see ourselves as part of—not objectively disconnected from—broader mass movements building power against fascism and pursuing liberation for all.
Gene expression, micro‐CT and histomorphometrical analysis of sinus floor augmentation with biphasic calcium phosphate and deproteinized bovine bone mineral: A randomized controlled clinical trial
Authors: Arunjaroensuk Sirida , Nampuksa Katanchalee , Monmaturapoj Naruporn , Thunyakitpisal Pasutha , Porntaveetus Thantrira , Mattheos Nikos , Pimkhaokham Atiphan 
Published: February 2024

AbstractAimsThe aim of this randomized controlled clinical trial was to compare the gene expression, micro‐CT, histomorphometrical analysis between biphasic calcium phosphate (BCP) of 70/30 ratio and deproteinized bovine bone mineral (DBBM) in sinus augmentation.Materials and MethodsTwenty‐four patients in need for sinus floor augmentation through lateral approach were randomized into BCP 70/30 ratio or DBBM. After at least 6 months of healing, a total of 24 bone specimens were collected from the entire height of the augmented bone at the area of implant placement and underwent micro‐CT, histomorphometric and gene expression analysis. The 12 bone specimens of BCP 70/30 ratio were equally allocated to micro‐CT and histologic analysis (test group, n = 6) and gene expression analysis (test group, n = 6). Similarly, the 12 bone specimens of DBBM were also allocated to micro‐CT and histologic analysis (control group, n = 6) and gene expression analysis (control group, n = 6). The newly formed bone, remaining graft materials and relative change in gene expression of four target genes were assessed.ResultsThe micro‐CT results showed no statistically significant difference in the ratio of bone volume to total volume (BV/TV ratio) for the two groups (BCP 41.51% vs. DBBM 40.97%) and the same was true for residual graft material to total volume (GV/TV ratio, BCP 9.97% vs. DBBM 14.41%). Similarly, no significant difference was shown in the histological analysis in terms of bone formation, (BCP 31.43% vs. DBBM was 30.09%) and residual graft area (DBBM 40.76% vs. BCP 45.06%). With regards to gene expression, the level of ALP was lower in both groups of bone grafted specimens compared with the native bone. On the contrary, the level of OSX, IL‐1B and TRAP was higher in augmented bone of both groups compared with the native bone. However, the relative difference in all gene expressions between BCP and DBBM group was not significant.ConclusionsThe BCP, HA/β‐TCP ratio of 70/30 presented similar histological and micro‐CT outcomes in terms of new bone formation and residual graft particles with DBBM. The gene expression analysis revealed different gene expression patterns between augmented and native bone, but showed no significant difference between the two biomaterials.
Bioenergy feedstock supply from wheat straw: A farm level model incorporating trade‐offs in crop choices, disease risk, and soil fertility
Authors: McKnight Curtis J. , Hauer Grant , Luckert Marty , Qiu Feng 
Published: February 2024

AbstractSecond‐generation biofuel (e.g., ethanol, renewable diesel) can be made from crop residues. However, the availability of residues for biofuel production is uncertain, because farmers have the option to grow different crops and use the residues for alternative purposes, such as livestock bedding and feed, or leave them in the field to improve soil quality. Taking Canadian wheat straw supply as an example, we develop a dynamic programming model to investigate a farmer's wheat straw supply decision in response to different wheat straw and grain prices. Our model considers crop choices between wheat and canola in the context of disease risk, the trade‐off between the immediate payoffs a farmer may receive from bailing and selling wheat straw, and the long‐term adverse effects that removing wheat straw from the soil surface may have on wheat and canola yields. The results from this study provide insights into how farm‐level supply decisions, in response to wheat straw price changes, affect soil quality dynamics and scale up to regional wheat straw supply for biofuel production. This information also has implications for land use change and the sustainability of feedstock supply for biofuels.
A phase I trial assessing the safety, pharmacokinetics, cerebrospinal fluid penetrance, and food effect of BTK inhibitor tolebrutinib in healthy volunteers
Authors: Cabanis Marie‐José , Nicolas Olivier , Vitse Olivier , Jan Christelle , Brun Priscilla , Soubayrol Patrick , Smith William B. , Turner Timothy J. , Krupka Emmanuel 
Published: February 2024

AbstractTolebrutinib is an oral, brain‐penetrant, covalent Bruton's tyrosine kinase inhibitor in development to treat multiple sclerosis at 60 mg/day with food. A phase I trial was conducted in healthy volunteers to assess the safety and pharmacokinetics of tolebrutinib at oral doses higher than 60 mg with food and during fasting, and to determine cerebrospinal fluid (CSF) exposure after a single dose of 60 or 120 mg with food. The trial included double‐blind, placebo‐controlled single ascending dose (120, 240, and 300 mg; fed and fasted) and multiple ascending dose (120, 180, and 240 mg) arms. Additional open‐label cohorts received a single 60 mg dose with a high‐fat meal and during fasting using a crossover design or a single 60 or 120 mg dose with food and lumbar puncture to obtain CSF. Tolebrutinib was rapidly absorbed and converted to an active metabolite (designated “M2”), both of which had a terminal half‐life of ~5 h. Tolebrutinib and M2 exposures increased following administration with food versus fasting, and plasma levels were generally dose proportional. For up to 4 h (the last measurement timepoint) after a 60 mg dose, CSF concentrations of tolebrutinib exceeded its in vitro cellular potency (half‐maximal inhibitory concentration [IC50]) for microglia, and tolebrutinib and M2 surpassed their biochemical IC50. Tolebrutinib was well‐tolerated, and treatment‐emergent adverse events were generally mild. Concentration‐QTc modeling showed no effects on QT/QTc intervals for any tolebrutinib dose or fed status. In conclusion, tolebrutinib has an acceptable safety profile at supratherapeutic doses and achieved bioactive CSF exposures at the phase III dose.
Direct and indirect effects of mother's spatial ability on child's spatial ability: What role does the home environment play?
Authors: Garcia‐Sanchez Nelcida L. , Dick Anthony Steven , Hayes Timothy , Pruden Shannon M. 
Published: February 2024

AbstractIndividual differences in spatial thinking are predictive of children's math and science achievement and later entry into Science, Technology, Engineering, and Mathematics (STEM) disciplines. Little is known about whether parent characteristics predict individual differences in children's spatial thinking. This study aims to understand whether, and to what extent, mother's intrinsic (i.e., mental rotation) and extrinsic (i.e., spatial scaling) spatial ability directly and indirectly, via the variation in home spatial environment, predicts children's intrinsic and extrinsic spatial ability. A total of 165 mothers and their 4–6‐year‐old children were recruited to participate in a remote video session with an experimenter. Mothers were administered a forced‐choice Intrinsic Spatial Toy Preference Task gauging their preference for highly spatial versus less spatial toys and asked questions with the Home Intrinsic Spatial Environmental Questionnaire about the frequency with which they engage their child in spatial activities at home. Mothers completed a Mental Rotations Test and a Spatial Scaling Task adapted for adults. Children were administered the Picture Rotation Task, the Spatial Scaling Task, and the Peabody Picture Vocabulary Test. Structural equation modeling was used to examine direct and indirect, via home spatial environment and toy choices, influences of mother spatial ability on child spatial ability. Contrary to our predictions, we did not find direct, nor indirect, relations between mother and child spatial ability. These findings suggest that researchers should consider alternative conceptualizations of the early home spatial environment beyond the frequency of spatial play in the home.Research Highlights
The identification of factors that predict individual differences in children's spatial ability is important in order to maximize STEM learning outcomes.
Data collection was conducted remotely rather than in traditional preschool or laboratory settings.
Contrary to our pre‐registered hypotheses, no significant relations between mother spatial ability, the early home spatial environment, and children's development of spatial skills were found.
Future research should consider examining the amount of spatial language used in the home or the quality of parent–child interactions during spatial play as potential explanations for individual differences in children's spatial ability.
Global Health Impact: Human rights, access to medicines, and measurement
Authors: Hassoun Nicole 
Published: February 2024

AbstractShould people have a legal human right to health? And, if so, what exactly does protecting this right require? This essay defends some answers to these questions recently articulated in Global Health Impact. It explains how these answers depend on a particular way of thinking about health and the minimally good life, how quality of life matters at and over time, what various agents should do to help people who are unable to live well enough, and many other things. Moreover, it suggests some ways of improving common metrics for measuring and advancing our collective global health impact.