bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doing leadership differently as resistance: Care‐fully reworking Aotearoa New Zealand's research system
Authors: Cox Bethany , Locke Kirsten , Sharp Emma , Rayne Aisling , Walker Leilani , Steeves Tammy 
Published: November 2023

AbstractThe ‘research system’ in Aotearoa New Zealand is rife with obstacles for entry and retention of diversity. The research system's complexity and longevity gives the impression of stability and fixity, but we argue it is characterised by a lack of imagination around leadership that generates change. In this article, we examine the embodied experiences of research leadership, as encountered by participants at Aotearoa New Zealand's universities and a nationally funded Centre of Research Excellence. It is within such institutions and organisations, built on colonial and patriarchal values, that experiences of marginalisation, oppression and harassment have been documented. We destabilise the apparently static nature of this ‘research system monolith’ by taking up MacLeavy, Fannin and Larner's (2021) provocation of a feminist approach to boldly do leadership differently. Drawing from interviews with researchers, we argue that resistance to, and reworking of, the research system can be found in feminist modes of practice: in the everyday, mundane practices of care‐full research leadership that do leadership differently.
Topical therapy and skin care for transplant‐associated atopic dermatitis in children and adolescents
Authors: Horino Satoshi , Yamaguchi Yuki , Miyabayashi Hiroki , Aki Haruka , Nanjo Yuka , Onuma Masaei , Rikiishi Takeshi , Yabe Hiromasa , Imaizumi Masue , Sato Atsushi , Miura Katsushi 
Published: November 2023

AbstractBackgroundNew‐onset allergic diseases, such as food allergy or atopic dermatitis, can develop after allogeneic transplantation. There are limited reports of new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation in children and adolescents, and its treatment is yet to be established. The pathogenesis may differ from typical atopic dermatitis in terms of alloimmunity including graft‐versus‐host disease.MethodsWe present five children and adolescents with new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation. The characteristics and clinical profiles of skin treatment after hematopoietic stem cell transplantation are summarized.ResultsGraft‐versus‐host disease prophylaxis included systemic tacrolimus for all patients. After hematopoietic stem cell transplantation, all patients achieved complete donor chimerism of the bone marrow and had acute graft‐versus‐host disease of the skin. After engraftment, all patients had skin lesions that met the international consensus diagnostic criteria for atopic dermatitis. None of the patients met the diagnostic criteria for chronic graft‐versus‐host disease. Topical therapy and skin care based on atopic dermatitis guidelines improved skin condition and atopic dermatitis severity scores in all patients. In addition, type 2 inflammatory markers improved accordingly.ConclusionTopical therapy and skin care may be effective for transplant‐related atopic dermatitis after hematopoietic stem cell transplantation. When extensive dermatitis is observed after hematopoietic stem cell transplantation, this treatment may avoid excessive immunosuppressive therapy if it meets the diagnostic criteria for atopic dermatitis.
Uncovering the role of substance use in suicide attempts using a mixed‐methods approach
Authors: Diefenbach Gretchen J. , Stubbing Jessica , Rice Tyler B. , Lord Kayla A. , Rudd M. David , Tolin David F. 
Published: November 2023

AbstractIntroductionSubstance use is an established risk factor for suicide attempt. Clarifying the role of substance use in suicide attempts may identify modifiable treatment targets. This study used mixed methods to associate substance use with suicide attempt history and identify pathways through which substance use contributes to attempts.MethodsStudy 1 included 213 adult inpatients (n = 127 with substance use disorder [SUD]), who completed assessments of suicide attempt history as well as demographic and clinical suicide risk factors. Study 2 was a narrative analysis of suicide attempt stories described by 20 inpatients diagnosed with SUD.ResultsIn Study 1, patients with co‐occurring alcohol and drug use disorders reported more actual lifetime suicide attempts than did those without SUD. In addition, alcohol and drug use disorders were independently associated with lifetime suicide attempts after controlling for demographic and clinical confounders. In Study 2, substance use played a role in all suicide attempts through at least one pathway before, during, or after a triggering stressor, or as suicide attempt method.ConclusionsSubstances play a role in suicide attempt baseline risk, acute risk and as means. It is important to target chronic and acute substance use in suicide prevention treatment plans.
Effect of a single session of sensorimotor rhythm neurofeedback training on the putting performance of professional golfers
Authors: Wu Jia‐Hao , Chueh Ting‐Yu , Yu Chien‐Lin , Wang Kuo‐Pin , Kao Shih‐Chun , Gentili Rodolphe J. , Hatfield Bradley D. , Hung Tsung‐Min 
Published: November 2023

AbstractSensorimotor rhythm (SMR) activity has been associated with automaticity and flow in motor execution. Studies have revealed that neurofeedback training (NFT) of the SMR can improve sports performance; however, few studies have adequately explored the effects of a single session of such NFT or examined the possible mechanisms underlying these effects on sports performance. This study recruited 44 professional golfers to address these gaps in the literature. A crossover design was employed to determine the order of the participation in the NFT and no‐training control conditions. The participants were asked to perform 60 10‐foot putts while electroencephalograms (EEGs) were recorded before and after the tasks. In pre‐and post‐tests, visual analog scales were used to assess the psychological states associated with SMR activities including the levels of attention engagement, conscious motor control, and physical relaxation. The results revealed that a single NFT session effectively increased SMR power and improved putting performance compared with the control condition. The subjective assessments also revealed that the participants reported lower attention engagement, less conscious control of the motor details and were more relaxed in the putting task, suggesting that SMR NFT promoted effortless and quiescent mental states during motor preparation for a putting task. This study aligns with theoretical hypotheses and extends current knowledge by revealing that a single session of SMR NFT can effectively enhance SMR power and improve putting performance in professional golfers. It also provides preliminary evidence of the possible underlying mechanisms that drive the effect of SMR NFT on putting performances.
Degassing of soil gas radon and its implication to fault activity in the western margin of the Ordos Block, China
Authors: Liu Zhaofei , Chen Zhi , Li Ying , Du Peng , Zhao Yuanxin , Lei Lei , Lu Chang , Huangfu Ruilin 
Published: November 2023

AbstractSoil gas radon (Rn) serves as an effective indicator for assessing fault activity in fault zones. Measurement of Rn degassing at the active faults was conducted twice in 2017 and 2018 to assess fault activity in the western margin of the Ordos block. The concentration and flux values of Rn ranged from 0.41 to 40.93 kBq m−3 and 5.17 to 140.33 mBq m−2 s−1, respectively. The compression of the Tibetan Plateau has led to higher Rn concentration and flux in the southern part compared with the northern part. The fault activity is evaluated by the index of IRn calculated from Rn concentrations. The Haiyuan arcuate tectonic region exhibited the most intensive fault activity, followed by the Yinchuan Basin and Jilantai‐Linhe Basin. These findings enhance our understanding of the relationship between fault activity and Rn emission and provide a significant geochemical reference for the fault activity.
Breakthrough SARS‐CoV‐2 infections among recipients of tixagevimab‐cilgavimab prophylaxis: A citywide real‐world effectiveness study
Authors: Lendacki Frances R. , Li Linda , Forrest Graeme N. , Jordan Leirah , Zelinski Christy , Black Stephanie R. , Ison Michael G. , Seo Jennifer Y. 
Published: November 2023

AbstractThere are limited real‐world data on the effectiveness of tixagevimab‐cilgavimab as pre‐exposure prophylaxis of COVID‐19. We describe lessons learned when coordinating data collection and identifying breakthrough SARS‐CoV‐2 infections among patients across indications and institutions in a major US city. The Chicago Department of Public Health requested patient‐level tixagevimab‐cilgavimab administration data from all prescribing providers in Chicago, for treatments December 8, 2021 through June 30, 2022. Records were matched to COVID‐19 vaccinations and laboratory‐confirmed SARS‐CoV‐2 infections through December 31, 2022. Due to difficulty collecting data from all providers, targeted follow‐up was conducted to improve completeness on key variables (demographics, vaccination status, clinical indication for prophylaxis). Over half of reported tixagevimab‐cilgavimab administrations were to patients residing outside Chicago. Five hundred forty‐four Chicago residents who received at least one dose of tixagevimab‐cilgavimab were included in this analysis. Most were age 50 years or older (72%), Black non‐Latinx (33%) or White non‐Latinx (29%), and fully vaccinated (80%). Seventy‐five patients (14%) had laboratory‐confirmed COVID‐19. Patients with and without breakthrough infections were demographically similar. Clinical indication was missing for >95% of cases, improved to 64% after follow‐up; the most frequently specified was hematologic malignancy (10%). Severe outcomes were uncommon: 16% had documented COVID‐19‐related hospitalizations, one death was identified. Tixagevimab‐cilgavimab recipients in Chicago had a lower rate of severe SARS‐CoV‐2 infection than reported among other untreated high‐risk patients, including during predominance of non‐neutralizing variants. Improving stakeholder collaboration is essential for generation of real‐world effectiveness data, informing pandemic preparedness and optimizing use of medical countermeasures.
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Approach to diagnostic evaluation and prevention of invasive fungal disease in patients prior to allogeneic hematopoietic stem cell transplant
Authors: O'Keeffe Jessica C. , Singh Nikhil , Slavin Monica A. 
Published: November 2023

AbstractIn recent years, advancements in the treatment landscape for hematological malignancies, such as acute myeloid leukemia and acute lymphoblastic leukemia, have significantly improved disease prognosis and overall survival. However, the treatment landscape is changing and the emergence of targeted oral therapies and immune‐based treatments has brought forth new challenges in evaluating and preventing invasive fungal diseases (IFDs). IFD disproportionately affects immunocompromised hosts, particularly those undergoing therapy for acute leukemia and allogeneic hematopoietic stem cell transplant. This review aims to provide a comprehensive overview of the pretransplant workup, identification, and prevention of IFD in patients with hematological malignancy. The pretransplant period offers a critical window to assess each patient's risk factors and implement appropriate prophylactic measures. Risk assessment includes evaluation of disease, host, prior treatments, and environmental factors, allowing a dynamic evaluation that considers disease progression and treatment course. Diagnostic screening, involving various biomarkers and radiological modalities, plays a crucial role in early detection of IFD. Antifungal prophylaxis choice is based on available evidence as well as individual risk assessment, potential for drug–drug interactions, toxicity, and patient adherence. Therapeutic drug monitoring ensures effective antifungal stewardship and optimal treatment. Patient education and counselling are vital in minimizing environmental exposures to fungal pathogens and promoting medication adherence. A well‐structured and individualized approach, encompassing risk assessment, prophylaxis, surveillance, and patient education, is essential for effectively preventing IFD in hematological malignancies, ultimately leading to improved patient outcomes and overall survival.
Motivic Pontryagin classes and hyperbolic orientations
Authors: Haution Olivier 
Published: November 2023

AbstractWe introduce the notion of hyperbolic orientation of a motivic ring spectrum, which generalises the various existing notions of orientation (by the groups , , , ). We show that hyperbolic orientations of ‐periodic ring spectra correspond to theories of Pontryagin classes, much in the same way that ‐orientations of arbitrary ring spectra correspond to theories of Chern classes. We prove that ‐periodic hyperbolically oriented cohomology theories do not admit further characteristic classes for vector bundles, by computing the cohomology of the étale classifying space . Finally, we construct the universal hyperbolically oriented ‐periodic commutative motivic ring spectrum, an analogue of Voevodsky's cobordism spectrum .
Whisker kinematics in the cerebellum
Authors: Zhai Peipei , Romano Vincenzo , Soggia Giulia , Bauer Staf , van Wingerden Nathalie , Jacobs Thomas , van der Horst Annabel , White Joshua J. , Mazza Roberta , De Zeeuw Chris I. 
Published: November 2023

AbstractThe whisker system is widely used as a model system for understanding sensorimotor integration. Purkinje cells in the crus regions of the cerebellum have been reported to linearly encode whisker midpoint, but it is unknown whether the paramedian and simplex lobules as well as their target neurons in the cerebellar nuclei also encode whisker kinematics and if so which ones. Elucidating how these kinematics are represented throughout the cerebellar hemisphere is essential for understanding how the cerebellum coordinates multiple sensorimotor modalities. Exploring the cerebellar hemisphere of mice using optogenetic stimulation, we found that whisker movements can be elicited by stimulation of Purkinje cells in not only crus1 and crus2, but also in the paramedian lobule and lobule simplex; activation of cells in the medial paramedian lobule had on average the shortest latency, whereas that of cells in lobule simplex elicited similar kinematics as those in crus1 and crus2. During spontaneous whisking behaviour, simple spike activity correlated in general better with velocity than position of the whiskers, but it varied between protraction and retraction as well as per lobule. The cerebellar nuclei neurons targeted by the Purkinje cells showed similar activity patterns characterized by a wide variety of kinematic signals, yet with a dominance for velocity. Taken together, our data indicate that whisker movements are much more prominently and diversely represented in the cerebellar cortex and nuclei than assumed, highlighting the rich repertoire of cerebellar control in the kinematics of movements that can be engaged during coordination.
imageKey points
Excitation of Purkinje cells throughout the cerebellar hemispheres induces whisker movement, with the shortest latency and longest duration within the paramedian lobe.
Purkinje cells have differential encoding for the fast and slow components of whisking.
Purkinje cells encode not only the position but also the velocity of whiskers.
Purkinje cells with high sensitivity for whisker velocity are preferentially located in the medial part of lobule simplex, crus1 and lateral paramedian.
In the downstream cerebellar nuclei, neurons with high sensitivity for whisker velocity are located at the intersection between the medial and interposed nucleus.
An RBM10 and NF-κB interacting host lncRNA promotes JEV replication and neuronal cell death
Authors: Tripathi Shraddha , Sengar Suryansh , Shree Bakhya , Mohapatra Stuti , Basu Anirban , Sharma Vivek 
Published: November 2023

ABSTRACT

Infection of the central nervous system by the Japanese encephalitis virus (JEV) is characterized by extensive neuronal cell death and neuroinflammation. Several protein-coding genes and microRNAs are implicated in JEV-induced neuronal cell death. However, the global expression patterns and functional contributions of long non-coding RNAs (lncRNAs) during JEV-induced neuronal cell death have not been explored. Here, we profiled the transcriptome of the JEV-infected neuronal cell line and identified several lncRNAs whose expression is altered during JEV infection. We functionally characterized a lncRNA named
JINR1
(JEV-induced non-coding RNA 1), which is evolutionarily conserved in primates.
JINR1
induction during JEV infection is regulated by nuclear factor-kappa B (NF-κB). Depletion of
JINR1
during infection reduces flavivirus replication, neuronal cell death, and the expression of genes involved in ER stress and neuroinflammation. Interestingly, GRP78 overexpression prevents the decrease in flavivirus replication due to
JINR1
knockdown.
JINR1
interacts with RBM10 and NF-κB to regulate the transcription of virus
-
induced genes. In addition, RBM10 and
JINR1
form a feed-forward loop to reciprocally promote each other’s expression by regulating NF-κB activity. Our results suggest the role of
JINR1
in promoting flavivirus replication and flavivirus-induced neuronal cell death.

IMPORTANCE

Central nervous system infection by flaviviruses such as Japanese encephalitis virus, Dengue virus, and West Nile virus results in neuroinflammation and neuronal damage. However, little is known about the role of long non-coding RNAs (lncRNAs) in flavivirus-induced neuroinflammation and neuronal cell death. Here, we characterized the role of a flavivirus-induced lncRNA named
JINR1
during the infection of neuronal cells. Depletion of
JINR1
during virus infection reduces viral replication and cell death. An increase in GRP78 expression by
JINR1
is responsible for promoting virus replication. Flavivirus infection induces the expression of a cellular protein RBM10, which interacts with
JINR1
. RBM10 and JINR1 promote the proinflammatory transcription factor NF-κB activity, which is detrimental to cell survival.
Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay
Authors: Hao Pengfei , Qu Qiaoqiao , Pang Zhaoxia , Li Letian , Du Shouwen , Shang Limin , Jin Chaozhi , Xu Wang , Ha Zhuo , Jiang Yuhang , Chen Jing , Gao Zihan , Jin Ningyi , Wang Jian , Li Chang 
Published: November 2023

ABSTRACT
Rotavirus (RV) is one of the most significant pathogens in humans and animals with diarrhea worldwide. Cell entry is the first step in viral infection, and the outer capsid protein VP4 is crucial for RV attachment and internalization. In order to discover novel candidate host factors involved in RV cell entry, a proximity labeling method was applied to systematically investigate the VP4 and host protein interactions. A total of 174 high-confidence host proteins were identified using proximity labeling. Further analysis showed that 88 proteins were located in the cytoskeleton, plasma membrane, and extracellular region, which could be involved in RV entry. Importantly, vimentin (VIM) and actin-related protein 2 (ACTR2) were identified to promote RV infection at an early step. The results of co-immunoprecipitation assay showed that VIM or ACTR2 physically interacted with VP4. Blocking VIM or ACTR2 function by silencing with small interfering RNA or inhibition by specific antibodies significantly restricted RV infection. Furthermore, increasing the amounts of VIM or ACTR2 by overexpression from transfected recombinant proteins or incubation with recombinant proteins promoted RV infection. Collectively, this study revealed that RV VP4 interacted with host proteins and demonstrated that interaction with VIM and ACTR2 promoted RV replication, providing valuable resources and potential drug targets for better understanding and treating this disease.

IMPORTANCE
Rotavirus (RV) is an important zoonosis virus, which can cause severe diarrhea and extra-intestinal infection. To date, some proteins or carbohydrates have been shown to participate in the attachment or internalization of RV, including HGBAs, Hsc70, and integrins. This study attempted to indicate whether there were other proteins that would participate in the entry of RV; thus, the RV VP4-interacting proteins were identified by proximity labeling. After analysis and verification, it was found that VIM and ACTR2 could significantly promote the proliferation of RV in intestinal cells. Through further viral binding assays after knockdown, antibody blocking, and recombinant protein overexpression, it was revealed that both VIM and ACTR2 could promote RV replication.
High-depth RNA-Seq data sets to investigate the differences in gene expression mediated by phasevarions in non-typeable
Haemophilus influenzae
Authors: Atack John M. , Brockman Kenneth L. , Bakaletz Lauren O. , Jennings Michael P. 
Published: November 2023

ABSTRACT

Non-typeable
Haemophilus influenzae
(NTHi) is a major bacterial pathogen of the human airway. We report high-depth coverage RNA-Seq data from prototype NTHi strains 723 and R2866, encoding two of the most common phase-variable ModA alleles found in NTHi strains, ModA2 and ModA10, respectively.
Isolation and genome sequence annotation of SallyK, a newly discovered cluster EG bacteriophage infecting
Microbacterium
Authors: Wood Paige R. , Sullivan Emily A. , Mathison Rylee T. , Hepworth Sariah M. , Graves R. Scott , Danklefsen Breanna , Almahie Omer , Serna Carlos , Hunt Dylan J. , Brewster Reganne , Bartholomew Skylar , Shurley Jack F. , Grinath Anna S. , Thomas Michael A. 
Published: November 2023

ABSTRACT

Discovered from soil in a flower planter in Pocatello, Idaho and using
Microbacterium foliorum
, SallyK is a lytic bacteriophage with a siphovirus morphology. It has a 62,883 bp-long genome with 103 putative genes. Based on gene content similarity to actinobacteriophages, SallyK is assigned to cluster EG.