bluuebunny/crossref_metadata_2025_split huggingface dataset:
High throughput screening of mesenchymal stromal cell morphological response to inflammatory signals for bioreactor-based manufacturing of extracellular vesicles that modulate microglia
Authors: Larey Andrew M. , Spoerer Thomas M. , Daga Kanupriya R. , Morfin Maria G. , Hynds Hannah M. , Carpenter Jana , Hines Kelly M. , Marklein Ross A. 
Published: November 2023

ABSTRACTDue to their immunomodulatory function, mesenchymal stromal cells (MSCs) are a promising therapeutic with the potential to treat neuroinflammation associated with neurodegenerative diseases. This function can be mediated by secreted extracellular vesicles (MSC-EVs). Despite established safety, MSC clinical translation has been unsuccessful due to inconsistent clinical outcomes resulting from functional heterogeneity. Current approaches to mitigate functional heterogeneity include ‘priming’ MSCs with inflammatory signals to enhance function. However, comprehensive evaluation of priming and its effects on MSC-EV function has not been performed. Clinical translation of MSC-EV therapies requires significant manufacturing scale-up, yet few studies have investigated the effects of priming in bioreactors. As MSC morphology has been shown to predict their immunomodulatory function, we screened MSC morphological response to an array of priming signals and evaluated MSC-EV identity and potency in response to priming in flasks and bioreactors. We identified unique priming conditions corresponding to distinct morphologies. These conditions demonstrated a range of MSC-EV preparation quality and lipidome, allowing us to discover a novel MSC-EV manufacturing condition, as well as gain insight into potential mechanisms of MSC-EV microglia modulation. Our novel screening approach and application of priming to MSC-EV bioreactor manufacturing informs refinement of larger-scale manufacturing and enhancement of MSC-EV function.Graphical AbstractHighlightsMSCs morphologically respond to inflammatory priming conditions.Priming ‘hits’ identified from morphological screen increase MSC-EV production.Priming MSCs in bioreactors enhances MSC-EV modulation of microglia.Changes in MSC-EV production and potency reflected by lipid content.First demonstration of effects of priming on MSC production of EVs in a bioreactor.
A mouse model of ZTTK syndrome reveals indispensable SON functions in organ development and hematopoiesis
Authors: Vukadin Lana , Park Bohye , Mohamed Mostafa , Li Huashi , Elkholy Amr , Torrelli-Diljohn Alex , Kim Jung-Hyun , Jeong Kyuho , Murphy James M , Harvey Caitlin A. , Dunlap Sophia , Gehrs Leah , Lee Hanna , Kim Hyung-Gyoon , Lee Seth N. , Stanford Denise , Barrington Robert A. , Foote Jeremy B. , Sorace Anna G. , Welner Robert S. , Hildreth Blake E. , Lim Ssang-Taek Steve , Ahn Eun-Young Erin 
Published: November 2023

AbstractRare diseases are underrepresented in biomedical research, leading to insufficient awareness. Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome is a rare disease caused by genetic alterations that result in heterozygous loss-of-function of SON. While ZTTK syndrome patients suffer from numerous symptoms, the lack of model organisms hamper our understanding of both SON and this complex syndrome. Here, we developedSonhaploinsufficiency (Son+/−) mice as a model of ZTTK syndrome and identified the indispensable roles ofSonin organ development and hematopoiesis.Son+/−mice recapitulated clinical symptoms of ZTTK syndrome, including growth retardation, cognitive impairment, skeletal abnormalities, and kidney agenesis. Furthermore, we identified hematopoietic abnormalities inSon+/−mice, similar to those observed in human patients. Surface marker analyses and single-cell transcriptome profiling of hematopoietic stem and progenitor cells revealed thatSonhaploinsufficiency inclines cell fate toward the myeloid lineage but compromises lymphoid lineage development by reducing key genes required for lymphoid and B cell lineage specification. Additionally,Sonhaploinsufficiency causes inappropriate activation of erythroid genes and impaired erythroid maturation. These findings highlight the importance of the full gene dosage ofSonin organ development and hematopoiesis. Our model serves as an invaluable research tool for this rare disease and related disorders associated with SON dysfunction.
Social determinants of adherence to social distancing measures among adults during the COVID-19 pandemic
Authors: Ghasemi Marzieh , Karimi-Shahanjarini Akram , Afshari Maryam , Tapak Leili 
Published: November 2023

PurposeUnderstanding the factors that influence individuals’ adherence to social distancing is critical to effective policymaking in respiratory pandemics such as COVID-19. This study aims to explore the role of social factors in relation to social distancing measures.Design/methodology/approachStratified convenience sampling was used in this survey research, involving 450 adults residing in both rural and urban areas of Aligodarz County, Lorestan, Iran.FindingsThe findings showed that approximately 14% of participants did not adhere to any of the assessed social distancing behaviors, while only around 30% adhered to all four assessed behaviors. On average, participants reported having 5.13 (SD = 3.60) close physical contact within the 24 h prior to completing the questionnaire. Bridging social capital and gender emerged as the most frequently observed predictors across the assessed social distancing measures. Additionally, age, employment status and residential setting were identified as influential factors for some of the evaluated measures.Originality/valueThis study contributes to the field by highlighting that the likelihood of non-adherence to social distancing measures tends to increase among male participants, those aged above 60, employed individuals, urban residents and those with a higher level of bridging social capital.
Reviewing the contribution of retrofitting for climate resilience in residential buildings
Authors: Hulathdoowage Nimasha Dilukshi , Karunasena Gayani , Udawatta Nilupa , Liu Chunlu 
Published: November 2023

Purpose
Over the years, the significance of retrofitting has gained much attention with the unveiling of its different applications, such as energy retrofit and deep retrofit, to enhance the climate-resilience of buildings. However, no single study comprehensively assesses the climate-resilience of retrofitting. The purpose of this study is to address this gap via a systematic literature review.

Design/methodology/approach
Quality journal studies were selected using the PRISMA method and analysed manually and using scientometrics. Three dimensions of climate-resilience, such as robustness, withstanding and recovery, were used to evaluate the contribution of retrofit measures for achieving climate-resilient houses across four climate zones: tropical, arid, temperate and cold.

Findings
Most passive measures can enhance the robustness of residential buildings but cannot verify for withstanding against immediate shocks and timely recovery. However, some passive measures, such as night-time ventilation, show excellent performance over all four climate zones. Active measures such as heating, ventilation and air conditioning and mechanical ventilation with heat recovery, can ensure climate-resilience in all three dimensions in the short-term but contribute to greenhouse gas emissions, further exacerbating the long-term climate. Integrating renewable energy sources can defeat this issue. Thus, all three retrofit strategies should appropriately be adopted together to achieve climate-resilient houses.

Research limitations/implications
Since the research is limited to secondary data, retrofit measures recommended in this research should be further investigated before application.

Originality/value
This review contributes to the knowledge domain of retrofitting by assessing the contribution of different retrofit measures to climate-resilience.
A multi-voiced account of family entrepreneuring research: expanding the agenda of family entrepreneurship
Authors: Al-Dajani Haya , Bang Nupur Pavan , Basco Rodrigo , Calabrò Andrea , Cheng Jeremy Chi Yeung , Clinton Eric , Daspit Joshua J. , De Massis Alfredo , Discua Cruz Allan , Garcia-Lorenzo Lucia , Gartner William B. , Germain Olivier , Gherardi Silvia , Helin Jenny , Imas Miguel , Jack Sarah , McAdam Maura , Radu-Lefebvre Miruna , Rovelli Paola , Tillmar Malin , Torchia Mariateresa , Verduijn Karen , Welter Friederike 
Published: November 2023

PurposeThis conceptual, multi-voiced paper aims to collectively explore and theorize family entrepreneuring, which is a research stream dedicated to investigating the emergence and becoming of entrepreneurial phenomena in business families and family firms.Design/methodology/approachBecause of the novelty of this research stream, the authors asked 20 scholars in entrepreneurship and family business to reflect on topics, methods and issues that should be addressed to move this field forward.FindingsAuthors highlight key challenges and point to new research directions for understanding family entrepreneuring in relation to issues such as agency, processualism and context.Originality/valueThis study offers a compilation of multiple perspectives and leverage recent developments in the fields of entrepreneurship and family business to advance research on family entrepreneuring.
CSR commitment and consumer situational scepticism of luxury brands: antecedents, moderator and outcomes
Authors: Teah Kevin , Phau Ian , Sung Billy 
Published: November 2023

Purpose
This study aims to investigate the moderating role of corporate social responsibility (CSR) commitment in the relationships between antecedents and outcomes of consumer situational scepticism towards luxury brands.

Design/methodology/approach
The study used a questionnaire administered through a consumer panel, using established scales. A 2 (fictional, non-fictional) × 2 (low commitment, high commitment) factorial experimental design with four cells was implemented.

Findings
The results revealed that values-driven motives were associated with lower consumer situational scepticism, whereas egoistic-driven motives were linked to higher levels of consumer situational scepticism, regardless of the CSR commitment level of the luxury brand. However, the impact of strategic-driven motives and stakeholder-driven motives on consumer situational scepticism was only significant within the low commitment condition. Consumer situational scepticism was found to lead to lower brand resonance and resilience to negative information in both low and high commitment conditions.

Originality/value
This study contributes new knowledge by highlighting the crucial role of motives in shaping consumer perceptions, including scepticism, brand resonance and resilience to negative information, ultimately influencing consumer advocacy. The study further demonstrates that high commitment weakens the relationship between strategic-driven and stakeholder-driven motives and consumer scepticism. Moreover, high commitment also weakens the relationship between scepticism and the key outcomes examined in the study.
The impact of boundary conditions on the relationship between value creation and value appropriation in buyer-supplier relationships
Authors: Huang Ming-Chang , Lin Ting-Chuan , Lin Ping-Hsin , Chiu Ya-Ping , Chung Chi-Hung 
Published: November 2023

Purpose
This study aims to investigate whether higher value creation leads to higher value appropriation and to identify the boundary conditions in a buyer–supplier relationship that can explain why a particular supplier can appropriate higher value than others.

Design/methodology/approach
The study uses questionnaire surveys. The sample of the survey has 150 publicly-listed supplier firms in Taiwan. The unit of analysis is the buyer–supplier relationship.

Findings
In the buyer–supplier relationship, suppliers’ bargaining power, partnership and a supplier’s original brand manufacturing (OBM) business can strengthen the positive relationship between value creation and value appropriation.

Research limitations/implications
This study adopts the unilateral viewpoint of suppliers; however, some constructs might require dyadic evaluation. This study only explores the spillover effect of OBM business on the relationship between value creation and appropriation.

Practical implications
The spillover effect of a supplier’s OBM business in a buyer–supplier relationship allows the buyer to share more common benefits and the supplier to capture more private benefits as compensation. By broadening its customer base, a supplier can increase its bargaining power. A supplier can also maintain a strategic partnership with each essential buyer.

Originality/value
To avoid the dark-side effect of partnership, the model provides the contingency that a supplier can capture more value from a buyer–supplier relationship.
Role of gender in white-collar crime: an examination of the emancipation and focal concerns hypotheses
Authors: Gupta Chander Mohan , Gottschalk Petter , Kamaei Maryam 
Published: November 2023

Purpose
This paper aims to understand the involvement of women in white-collar crime (WCC) also referred to as pink-collar crimes. WCC is present around the globe and has created a word for itself.

Design/methodology/approach
The paper is designed by studying the WCC in the area of Iran, Portugal, Norway, India and the USA.

Findings
The paper attempts to move beyond the traditional perspectives of emancipation versus focal concern, which argue that less inequality will increase women involvement in WCC versus women socializing into accepting responsibilities for social concerns by caring for others.

Research limitations/implications
As the data is restricted, this study is based on the limited data available on the internet.

Originality/value
This paper is an original work of the authors.
The mediating effect of psychological distress and bullying victimization on the relationship between alexithymia and fibromyalgia among school adolescents
Authors: Alslman Eman , Thultheen Imad , Hamaideh Shaher H. , Nofal Basema , Hamdan-Mansour Renad , Hamdan Mansour Ayman 
Published: November 2023

Purpose
This study aims to test the mediating effect of psychological distress and bullying victimization on the relationship between alexithymia and fibromyalgia (FM) among school adolescents.

Design/methodology/approach
This study used cross-sectional, correlational design. Data was collected using self-administered questionnaire. The sample consisted of 1,000 school adolescents at Grade 9–12 who were recruited randomly using multistrategic sampling technique.

Findings
The analysis showed that alexithymia was a significant predictor of FM (odds ratio [OR] = 1.065). Psychological distress was also a significant predictor of FM; however, its mediating effect resulted in drop of OR to 1.041. The joined effect of bulling victimization and psychological distress found to be significant although OR dropped from 1.065 to 1.039.

Research limitations/implications
The study highlights the significant role of school health nurses and mental health counselors to early detect and direct mental health interventions toward significant psychological problems among school adolescents.

Originality/value
I affirm this information has not been published or submitted for publication elsewhere. All authors approve the content of the manuscript and have contributed significantly to research involved/ the writing of the manuscript. The authors affirm their commitment to transfer copyright ownership to your journal if the manuscript is accepted for publication. The authors also affirm they will obtain any other copyright permission if deemed necessary within 30 days of acceptance for publication. All identifying information regarding the study participants has been omitted and this study was approved by the IRB at School of Nursing of the University of Jordan. The research conforms to the provisions of the Declaration of Helsinki in 1995 (as revised in Brazil, 2013). All participants gave informed consent for the research, and that their anonymity was preserved. None of the authors has financial or personal matters that may pose a conflict of interest.
American option evaluations using higher moments
Authors: Gaillardetz Patrice , Hachem Saeb 
Published: November 2023

Purpose
By using higher moments, this paper extends the quadratic local risk-minimizing approach in a general discrete incomplete financial market. The local optimization subproblems are convex or nonconvex, depending on the moment variants used in the modeling. Inspired by Lai et al. (2006), the authors propose a new multiobjective approach for the combination of moments that is transformed into a multigoal programming problem.

Design/methodology/approach
The authors evaluate financial derivatives with American features using local risk-minimizing strategies. The financial structure is in line with Schweizer (1988): the market is discrete, self-financing is not guaranteed, but deviations are controlled and reduced by minimizing the second moment. As for the quadratic approach, the algorithm proceeds backwardly.

Findings
In the context of evaluating American option, a transposition of this multigoal programming leads not only to nonconvex optimization subproblems but also to the undesirable fact that local zero deviations from self-financing are penalized. The analysis shows that issuers should consider some higher moments when evaluating contingent claims because they help reshape the distribution of global cumulative deviations from self-financing.

Practical implications
A detailed numerical analysis that compares all the moments or some combinations of them is performed.

Originality/value
The quadratic approach is extended by exploring other higher moments, positive combinations of moments and variants to enforce asymmetry. This study also investigates the impact of two types of exercise decisions and multiple assets.
Validation and cross‐cultural adaptation of the Italian version of the paediatric eating assessment tool (I‐PEDI‐EAT‐10) in genetic syndromes
Authors: Onesimo Roberta , Sforza Elisabetta , Triumbari Elizabeth Katherine Anna , Proli Francesco , Leoni Chiara , Giorgio Valentina , Rigante Donato , Trevisan Valentina , De Rose Cristina , Kuczynska Eliza Maria , Cerchiari Antonella , Pane Marika , Mercuri Eugenio , Belafsky Peter , Zampino Giuseppe 
Published: November 2023

AbstractBackgroundThe Pediatric Eating Assessment Tool (PEDI‐EAT‐10) is a reliable and valid tool for rapid identification of dysphagia in patients aged 18 months to 18 years.AimsTo translate and adapt the PEDI‐EAT‐10 into the Italian language and evaluate its validity and reliability.Methods & ProceduresThe translation and cross‐cultural adaptation of the tool consisted of five stages: initial translation, synthesis of the translations, back translation, expert committee evaluation and test of the prefinal version. The internal consistency of the translated tool was analysed in a clinical group composed of 200 patients with special healthcare needs aged between 18 months and 18 years. They were consecutively enrolled at the Rare Disease Unit, Paediatrics Department, Fondazione Policlinico Agostino Gemelli‐IRCCS, Rome. For test–retest reliability, 50 caregivers filled in the PEDI‐EAT‐10 questionnaire for a second time after a 2‐week period. Construct validity was established by comparing data obtained from patients with data from healthy participants (n = 200). The study was approved by the local ethics committee.Outcomes & ResultsPsychometric data obtained from patients (104 M; mean age = 8.08 ± 4.85 years; median age = 7 years) showed satisfactory internal consistency (Cronbach's α = 0.89) and test–retest reliability (Pearson r = 0.99; Spearman r = 0.96). A total of 30% of children were classified as having a high risk of penetration/aspiration. The Italian PEDI‐EAT‐10 mean total score of the clinical group was significantly different from that resulting from healthy participants.Conclusions & ImplicationsThe PEDI‐EAT‐10 was successfully translated into Italian, validated and found to be a reliable one‐page rapid screening tool to identify dysphagia in children and adolescents with special needs.What this paper addsWhat is already known on the subject
The PEDI‐EAT‐10 is a valid and reliable quick discriminative paediatric tool for identifying penetration/aspiration risks.What this paper adds to the existing knowledge
In the present study we successfully translated and adapted the PEDI‐EAT‐10 into the Italian language.What are the potential or actual clinical implications of this work?
This translation and adaptation increase access to valid feeding and swallowing assessment for children of Italian‐speaking families. In addition, the I‐PEDI‐EAT‐10 can suggest further assessment of patients’ swallowing abilities.
Ecological effects of a declining red wolf population
Authors: Murray A. , Sutherland R. , Kays R. 
Published: November 2023

AbstractCarnivores, especially wolves (Canis sp.), have profound impacts on their ecosystems, affecting the abundance and behavior of prey and competitors, but this has not been examined in detail for red wolves (C. rufus). We studied a population of red wolves that was reintroduced to eastern North Carolina in 1987 and initially thrived, peaking at 120 animals. Due to an increase in anthropogenic mortality and a decline in government support, the population experienced a crash starting in 2014. We evaluated changes in the relative abundance of prey and competitor species during the red wolf decline with 25 camera traps run primarily on National Wildlife Refuges from 2015 to 2021. If red wolves were having an ecological effect on the mammal community, we expected this effect would decline as the wolf population waned, resulting in increased prey and competitor populations. Supporting this, we found that relative abundance increased for most prey and competitor species including American black bear (Ursus americanus), bobcat (Lynx rufus), Virginia opossum (Didelphis virginiana) and Northern raccoon (Procyon lotor). For all species, this increase was most notable after spring 2018, the second year with low red wolf reproduction. For some species, the increase was dramatic; the detection rate for raccoon, bear and bobcat doubled from the spring of 2018 to the spring of 2021. White‐tailed deer (Odocoileus virginianus) showed a general increase in relative abundance but remained prevalent even at their lowest detection rates. Our results lend correlational support to the hypothesis that red wolves had a strong effect on their ecosystems by suppressing prey and competitor populations when they were at their peak. This study adds to the growing body of evidence that reintroductions of large predators have ecological impacts, with the caveat that these impacts can decline rapidly if the predators dwindle back to critically low numbers.