bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Trauma Care PADA IBU RUMAH TANGGA DALAM PENANGANAN CEDERA PADA ANAK DI RUMAH DI KELURAHAN MAMAJANG DALAM KOTA MAKASSAR
Authors: Hady Abd , Hariani Hariani , Simunati Simunati 
Published: October 2023

Masalah kecelakaan pada anak balita di rumah tangga masih menjadi masalah yang memerlukan penangan yang tepat. Di Indonesia tingkat pengetahuan ibu rendah, sikap yang kurang baik dan tindakan ibu yang kurang tepat penyebab kejadian kecelakaan pada anak (Budi utomo 2008).Menurut penelitian Mulyanti,(2015) angka kecelakaan Balita 86% dari 50 responden jenis kecelakaan jatuh 70%, luka bakar 23%, tersetrum listrik 23 kasus, tersedak 43%, terkena benda tajam 33%, bahkan tersedak 43 kasus penelitian yang dilakukan oleh Kuchithawati, menyebutukan bahwa praktik pencegahan cedera yang dilakukan oleh orang tua yaitu berupa tindakan pengawasan yang masih rendah, merupakan faktor yang paling berperan terhadap kejadian cedera pada anak setelah factor lingkungana yang tidak aman.Tujuan pengabdian masyarakat adalah meningkatkan keterampilan ibu tentang primary Trauma care dan mampu menolong dan mencegah terjadinya cedera pada anak, manfaat dari kegiatan pengabdian ini adalah meningkatkan kemandirian ibu dalam memberikan pertolongan kepada anaknya bila terjadi cedera dan sasaran dari pengabdian ini adalah pada ibu-ibu yang memiliki balita.Hasil pengabmas adalah terjadinya peningkatan pengetahuan tentang Primary Trauma Care pada ibu dalam penanganan cedera pada anak, terjadi peningkatan keterampilan tentang Primary Trauma Care pada ibu dalam penanganan cedera pada anak, Ibu- ibu lebih percaya diri dalam menangani cedera pada anak bila terjadi kecelakaan. Kata Kunci : Primary Trauma Care, ibu rumah tangga
UPAYA PEMENUHAN KUALITAS AIR BERSIH DENGAN METODE MULTIMEDIA FILTER DI KELURAHAN BAKUNG KECAMATAN BIRINGKANAYA KOTA MAKASSAR
Authors: Mulyadi Mulyadi , Khaer Ain , Budirman Budirman 
Published: October 2023

Upaya penyedian air bersih yang terstandar dari segi kualitas dan kuantitas sangat penting dilakukan dalam upaya pencegahan penularan penyakit, maka upaya pengolahan air bersih dimasyarakat perlu dibuat pada wilayah dengan kondisi rawan tergenang air dan ketersedian air bersih yang belum memenuhi persyaratan. Ketersedian air yang cukup namun masih memiliki ganguan kualitas terjadi diwilayah kelurahan berua suding kecamatan Biringkanaya Makassar, maka dengan upaya pengolahan air dengan metode Multimedia filter dalah salah satu solusi yang bisa diterapakan berdasarkan hasil penelitian yang telah teruji dan dilakukan sebelumnya. Dengan dilaksanakannya kegiatan pengabdian kepada masyarakat ini diharapkan masyarakat di kelurahan Berua Sudiang Kecamatan Biringkanaya Kota Makassar dapat mengetahui kualitas air bersih yang digunakan untuk air bersih layak konsumsi atau digunakan sehari-hari dengan menggunakan Multimedia Filter. Kegiatan pengabdian dilaksanakan selama empat bulan, yang dimulai dengan tahap persiapan, sosialisasi dengan tokoh masyarakat, setelah itu diberikan pelatihan dan pendampingan pembuatan alat. Luaran dari kegiatan pengabdian masyarakat yang dilakukan di kelurahan Berua Sudinag Kecamatan Biringkanaya Kota Makassar para peserta dapat memahami serta mengaplikasikan dalam kehidupan sehari-hari hasil dari penyuluhan, percontohan maupun pelatihan yang diberikan.Kata kunci: Air Bersih, Filter Multimedia, Pengolahan Air
ANALISIS KONDISI FASILITAS SANITASI PADA OBJEK WISATA DI PANTAI DEWATA WAKKA KABUPATEN PINRANG
Authors: Ruhban Andi , Indraswari Ni Luh Astri , Rismayanti Rismayanti 
Published: October 2023

Kenyamanan dan kesehatan wisatawan didukung dengan keutuhan fasilitas yang ada. Fasilitas sanitasi di objek wisata meliputi tempat sampah yang tidak tersedia, kamar mandi yang tidak bersih, air bersih yang tidak memenuhi syarat serta kurangnya penanganan air limbah dapat menjadi penyebab terjadinya penularan penyakit. Tujuan dari penelitian ini adalah untuk menganalisis fasilitas lingkungan pada objek wisata di pantai Dewata Wakka Pinrang. Penelitian dilakukan dengan metode survey deskriptif, sampel menggunakan teknik total sampling dimana semua fasilitas yang ada pada objek wisata pantai wakka menjadi sampelnya dengan analisis data secara kualitatif mengacu pada referensi yang relevan.Hasil dari penelitian menunjukkan bahwa air bersih pada objek Pantai Dewata Wakka Pinrang kecamatan Cempa kabupaten Pinrang tersedia dengan jumlah cukup, memenuhi persyaratan fisik karena menggunakan air Perusahaan Daerah Air Minum (PDAM), kondisi toilet umum tidak bersih dan tidak terpelihara karena kurangnya perhatian oleh pengelola toilet, pembuangan sampah tidak tersedia tempat sampah dengan jumlah yang cukup, tidak kuat, tidak tahan karat, tidak kedap air, permukaan tidak halus dan tidak berpenutup, tidak tersedia tempat penampungan sementara (TPS) yang memenuhi syarat dan kondisi saluran air limbah tidak dilakukan pengelolaan sendiri dan tidak disalurkan dengan saluran tertutup, kedap air dan lancar.Diharapkan untuk pihak pengelola objek wisata dapat memperbaiki kondisi fasilitas sanitasi objek wisata, dengan memperhatikan kebersihan dan kenyamanan bagi pengunjung dan diharapkan juga kepada pengunjung agar tetap menjaga kebersihan. Kata Kunci : Objek Wisata, Air Bersih, Toilet, Air Limbah, Sampah
Low switched memory B cells are associated with no humoral response after SARS-CoV-2 vaccine boosters in kidney transplant recipients
Authors: Seija Mariana , García-Luna Joaquin , Rammauro Florencia , Brugnini Andreína , Trías Natalia , Astesiano Rossana , Santiago José , Orihuela Natalia , Zulberti Catherine , Machado Danilo , Recalde Cecilia , Yandián Federico , Guerisoli Ana , Noboa Javier , Orihuela Sergio , Curi Lilian , Bugstaller Emma , Noboa Oscar , Nin Marcelo , Bianchi Sergio , Tiscornia Adriana , Lens Daniela 
Published: October 2023

IntroductionThe humoral response after SARS-CoV-2 vaccination and boosters in kidney transplant recipients (KTRs) is heterogeneous and depends on immunosuppression status. There is no validated immune measurement associated with serological response in clinical practice. Multicolor flow cytometric immunophenotyping could be useful for measuring immune response. This study aimed to study B- and T-cell compartments through Standardized EuroFlow PID Orientation after SARS-CoV-2 vaccination and their association with IgG SARS-CoV-2 seropositivity status after two doses or boosters.MethodsWe conducted a multicenter prospective study to evaluate humoral response after SARS-CoV-2 vaccination in KTRs. Heterologous regimen: two doses of inactivated SARS-CoV-2 and two boosters of BNT162b2 mRNA (n=75). Homologous vaccination: two doses of BNT162b2 mRNA and one BNT162b2 mRNA booster (n=13). Booster doses were administrated to KTRs without taking into account their IgG SARS-CoV-2 seropositivity status. Peripheral blood samples were collected 30 days after the second dose and after the last heterologous or homologous booster. A standardized EuroFlow PID Orientation Tube (PIDOT) and a supervised automated analysis were used for immune monitoring cellular subsets after boosters.ResultsA total of 88 KTRs were included and divided into three groups according to the time of the first detected IgG SARS-CoV-2 seropositivity: non-responders (NRs, n=23), booster responders (BRs, n=41), and two-dose responders (2DRs, n=24). The NR group was more frequent on mycophenolate than the responder groups (NRs, 96%; BRs, 80%; 2DRs, 42%; p=0.000). Switched memory B cells in the 2DR group were higher than those in the BR and NR groups (medians of 30, 17, and 10 cells/ul, respectively; p=0.017). Additionally, the absolute count of central memory/terminal memory CD8 T cells was higher in the 2DR group than in the BR and NR groups. (166, 98, and 93 cells/ul, respectively; p=0.041). The rest of the T-cell populations studied did not show a statistical difference.Conclusionswitched memory B cells and memory CD8 T-cell populations in peripheral blood were associated with the magnitude of the humoral response after SARS-CoV-2 vaccination. Boosters increased IgG anti-SARS-CoV-2 levels, CM/TM CD8 T cells, and switched MBCs in patients with seropositivity after two doses. Interestingly, no seropositivity after boosters was associated with the use of mycophenolate and a lower number of switched MBCs and CM/TM CD8 T cells in peripheral blood.
The efficacy and safety of cadonilimab combined with lenvatinib for first-line treatment of advanced hepatocellular carcinoma (COMPASSION-08): a phase Ib/II single-arm clinical trial
Authors: Qiao Qian , Han Chun , Ye Sisi , Li Juan , Shao Guoliang , Bai Yuxian , Xu Aibing , Sun Meili , Wang Wei , Wu Jian , Huang Ming , Song Lijie , Huang Luke , Liu Ting , Liu Wei , Wang Zhongmin Maxwell , Li Baiyong , Xia Michelle , Bai Li 
Published: October 2023

PurposeThis multicenter, open-label, phase Ib/II study aimed to assess the efficacy and safety of cadonilimab, a humanized, tetravalent, bispecific antibody plus lenvatinib in first-line treatment of advanced hepatocellular carcinoma (aHCC).MethodsPatients with histologically confirmed aHCC were included to receive either 6 mg/kg cadonilimab every 2 weeks plus lenvatinib (cohort A) or 15 mg/kg cadonilimab every 3 weeks plus lenvatinib (cohort B). The primary endpoint was objective response rate (ORR) by RECIST v1.1, while the secondary endpoints were safety, progression-free survival (PFS), overall survival (OS), disease control rate (DCR), duration of response (DoR), and time to response (TTR).ResultsA total of 59 patients were enrolled (31 in cohort A and 28 in cohort B). The median follow-up time was 27.4 months as of the data cutoff date (July 28, 2023). The ORR in cohort A was 35.5% (95% CI: 19.2, 54.6) and that in cohort B was 35.7% (95% CI: 18.6, 55.9), and the median DoR was 13.6 months (95% CI: 4.14, NE) and 13.67 months (95% CI: 3.52, NE), respectively. The median PFS was 8.6 months (95% CI: 5.2, 15.2) and 9.8 months (95% CI: 6.9, 15.2), respectively. The median OS was 27.1 months (95% C: 15.7, NE) for cohort A, while it was not reached for cohort B. Grade ≥ 3 treatment-related adverse events (TRAEs) were reported in 66.1% of patients, with serious TRAEs occurring in 39.0% of cases. Decreased platelet count (47.5%), proteinuria (45.8%), hypertension (44.1%), and white blood cell count (44.1%) were the most common TRAEs.ConclusionThis novel combination therapy showed promising efficacy and manageable toxicity that could provide an option in first-line setting of aHCC.Clinical Trial Registration[www.ClinicalTrials.gov], NCT04444167.
The safety and anti-tumor effect of multiple peptides-pulsed dendritic cells combined with induced specific cytotoxic T lymphocytes for patients with solid tumors
Authors: Zhao Xuan , Zhang Zhen , Wen Chunli , Huang Jianmin , Yang Shuangning , Liu Jinyan , Geng Huizhen , Peng Bing , Li Zibo , Zhang Yi 
Published: October 2023

ObjectiveThe aim of this study was to explore the safety and efficacy of multiple peptide-pulsed autologous dendritic cells (DCs) combined with cytotoxic T lymphocytes (CTLs) in patients with cancer.MethodsFive patients diagnosed with cancer between November 2020 and June 2021 were enrolled and received DC-CTLs therapy. Peripheral blood was collected and antigenic peptides were analyzed. The phenotype and function of DC-CTLs and the immune status of patients were detected using flow cytometry or IFN-γ ELISPOT analysis.ResultsDCs acquired a mature phenotype and expressed high levels of CD80, CD86, CD83, and HLA-DR after co-culture with peptides, and the DC-CTLs also exhibited high levels of IFN-γ. Peripheral blood mononuclear cells from post-treatment patients showed a stronger immune response to peptides than those prior to treatment. Importantly, four of five patients maintained a favorable immune status, of which one patient’s disease-free survival lasted up to 28.2 months. No severe treatment-related adverse events were observed.ConclusionOur results show that multiple peptide-pulsed DCs combined with CTLs therapy has manageable safety and promising efficacy for cancer patients, which might provide a precise immunotherapeutic strategy for cancer.
Ferroptosis-related genes as diagnostic markers for major depressive disorder and their correlations with immune infiltration
Authors: Chen Jingjing , Jiang Xiaolong , Gao Xin , Wu Wen , Gu Zhengsheng , Yin Ge , Sun Rui , Li Jiasi , Wang Ruoru , Zhang Hailing , Du Bingying , Bi Xiaoying 
Published: October 2023

BackgroundMajor depression disorder (MDD) is a devastating neuropsychiatric disease, and one of the leading causes of suicide. Ferroptosis, an iron-dependent form of regulated cell death, plays a pivotal role in numerous diseases. The study aimed to construct and validate a gene signature for diagnosing MDD based on ferroptosis-related genes (FRGs) and further explore the biological functions of these genes in MDD.MethodsThe datasets were downloaded from the Gene Expression Omnibus (GEO) database and FRGs were obtained from the FerrDb database and other literatures. Least absolute shrinkage and selection operator (LASSO) regression and stepwise logistic regression were performed to develop a gene signature. Receiver operating characteristic (ROC) curves were utilized to assess the diagnostic power of the signature. Gene ontology (GO) enrichment analysis was used to explore the biological roles of these diagnostic genes, and single sample gene set enrichment analysis (ssGSEA) algorithm was used to evaluate immune infiltration in MDD. Animal model of depression was constructed to validate the expression of the key genes.ResultsEleven differentially expressed FRGs were identified in MDD patients compared with healthy controls. A signature of three FRGs (ALOX15B, RPLP0, and HP) was constructed for diagnosis of MDD. Afterwards, ROC analysis confirmed the signature’s discriminative capacity (AUC = 0.783, 95% CI = 0.719–0.848). GO enrichment analysis revealed that the differentially expressed genes (DEGs) related to these three FRGs were mainly involved in immune response. Furthermore, spearman correlation analysis demonstrated that these three FRGs were associated with infiltrating immune cells. ALOX15B and HP were significantly upregulated and RPLP0 was significantly downregulated in peripheral blood of the lipopolysaccharide (LPS)-induced depressive model.ConclusionOur results suggest that the novel FRG signature had a good diagnostic performance for MDD, and these three FRGs correlated with immune infiltration in MDD.
Primary cilia-mediated regulation of microglial secretion in Alzheimer’s disease
Authors: Yeo Seungeun , Jang Jaemyung , Jung Hyun Jin , Lee Hyeyoung , Choe Youngshik 
Published: October 2023

Graphical AbstractMicroglial phagocytosis and exocytosis of Aβ are mediated by primary cilia, which influence extracellular proteostasis, Aβ plaque formation, and neurite dystrophy. When microglia in wild-type mice develop into the disease-associated state, they require genes involved in primary ciliogenesis and extracellular vesicle secretion. Inhibition of Ift88, a key cilia gene, in microglia stimulates phagocytosis and the secretion of extracellular vesicles with an altered proteomic composition, leading to the failure of extracellular proteostasis and neurite degeneration.
Functional changes of default mode network and structural alterations of gray matter in patients with irritable bowel syndrome: a meta-analysis of whole-brain studies
Authors: Zhao Mengqi , Hao Zeqi , Li Mengting , Xi Hongyu , Hu Su , Wen Jianjie , Gao Yanyan , Antwi Collins Opoku , Jia Xize , Yu Yang , Ren Jun 
Published: October 2023

BackgroundIrritable bowel syndrome (IBS) is a brain-gut disorder with high global prevalence, resulting from abnormalities in brain connectivity of the default mode network and aberrant changes in gray matter (GM). However, the findings of previous studies about IBS were divergent. Therefore, we conducted a meta-analysis to identify common functional and structural alterations in IBS patients.MethodsAltogether, we identified 12 studies involving 194 IBS patients and 230 healthy controls (HCs) from six databases using whole-brain resting state functional connectivity (rs-FC) and voxel-based morphometry. Anisotropic effect-size signed differential mapping (AES-SDM) was used to identify abnormal functional and structural changes as well as the overlap brain regions between dysconnectivity and GM alterations.ResultsFindings indicated that, compared with HCs, IBS patients showed abnormal rs-FC in left inferior parietal gyrus, left lingual gyrus, right angular gyrus, right precuneus, right amygdala, right median cingulate cortex, and left hippocampus. Altered GM was detected in the fusiform gyrus, left triangular inferior frontal gyrus (IFG), right superior marginal gyrus, left anterior cingulate gyrus, left rectus, left orbital IFG, right triangular IFG, right putamen, left superior parietal gyrus and right precuneus. Besides, multimodal meta-analysis identified left middle frontal gyrus, left orbital IFG, and right putamen as the overlapped regions.ConclusionOur results confirm that IBS patients have abnormal alterations in rs-FC and GM, and reveal brain regions with both functional and structural alterations. These results may contribute to understanding the underlying pathophysiology of IBS.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42022351342.
Research hotspots and trends in post-stroke dysphagia: a bibliometric analysis
Authors: Xu Fangyuan , Bai Lin , Dai Ziliang , Cheng Hongliang 
Published: October 2023

BackgroundDysphagia represents one of the common complications following a stroke, and post-stroke dysphagia (PSD) can lead to aspiration, pneumonia, and malnutrition, thus prolonging hospital stay, escalating medical expenditures, and imposing a substantial economic strain on both patients and society. The utilization of bibliometric analysis offers a quantitative approach for investigating the existing literature and recognizes the current status of the research. However, bibliometric analysis on the subject of PSD remains absent. Consequently, we carried out this study to provide researchers with insights, facilitating their further exploration of PSD.MethodsConducting a bibliometric analysis of articles pertaining to PSD retrieved over the past two decades enables us to acquire the research hotspots and trends in this area. The publications concerning PSD were searched from the Core Collection of Web of Science, spanning the period ranging from 2003 to 2023. Articles or reviews published in English were included in this study. Subsequently, we employed CiteSpace and VOSviewer software to visualize the retrieved articles, thereby identifying the cooperative relationships of authors, institutions, and countries, as well as relevant information about journals and references.ResultsThis study comprised 866 papers in total, and the number of articles published each year shows an overall growth trend. As for the analysis of the authors, Dziewas R. was the most prolific author with 21 articles. The most frequently published institutions, countries, and journals were the University of Manchester, China, and Dysphagia, with 28, 254, and 75 publications, respectively. And the co-cited authors and journals with the highest counts were Martino R and Stroke. According to the analysis of keywords and references, dysphagia screening and assessment, prevention of pneumonia, rehabilitation approaches, and nutritional management of PSD are considered research hotpots. Additionally, future research may focus on the topics of systematic review and meta-analysis, noninvasive brain stimulation, and lesion location.ConclusionThrough the bibliometrics analysis of PSD, we can capture the research hotspots and frontiers of PSD, thereby providing inspiration and reference for subsequent studies in this field.
Hippocampal atrophy is associated with hearing loss in cognitively normal adults
Authors: Shim Ye Ji , Jung Wi Hoon , Billig Alexander J. , Sedley William , Song Jae-Jin 
Published: October 2023

ObjectivesA growing body of evidence suggests that age-related hearing loss (HL) is associated with morphological changes of the cerebral cortex, but the results have been drawn from a small amount of data in most studies. The aim of this study is to investigate the correlation between HL and gray matter volume (GMV) in a large number of subjects, strictly controlling for an extensive set of possible biases.MethodsMedical records of 576 subjects who underwent pure tone audiometry, brain magnetic resonance imaging (MRI), and the Korean Mini-Mental State Exam (K-MMSE) were reviewed. Among them, subjects with normal cognitive function and free of central nervous system disorders or coronary artery disease were included. Outliers were excluded after a sample homogeneity check. In the end, 405 subjects were enrolled. Pure tone hearing thresholds were determined at 0.5, 1, 2, and 4 kHz in the better ear. Enrolled subjects were divided into 3 groups according to pure tone average: normal hearing (NH), mild HL (MHL), and moderate-to-severe HL (MSHL) groups. Using voxel-based morphometry, we evaluated GMV changes that may be associated with HL. Sex, age, total intracranial volume, type of MRI scanner, education level, K-MMSE score, smoking status, and presence of hypertension, diabetes mellitus and dyslipidemia were used as covariates.ResultsA statistically significant negative correlation between the hearing thresholds and GMV of the hippocampus was elucidated. Additionally, in group comparisons, the left hippocampal GMV of the MSHL group was significantly smaller than that of the NH and MHL groups.ConclusionBased on the negative correlation between hearing thresholds and hippocampal GMV in cognitively normal old adults, the current study indicates that peripheral deafferentation could be a potential contributing factor to hippocampal atrophy.