bluuebunny/crossref_metadata_2025_split huggingface dataset:
circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma
Authors: Liu Yuenan , Chen Kailei , Shou Yi , Li Sen , Wang Jun , Zhang Qingyang , Huang Ziwei , Xu Jiaju , Li Mingfeng , Liu Di , Liang Huageng , Yang Hongmei , Zhang Xiaoping 
Published: December 2023

AbstractAs the most prominent RNA modification, N6‐methyladenosine (m6A) participates in the regulation of tumour initiation and progression. Circular RNAs (circRNAs) also play crucial roles in ubiquitous life processes. Whether circRNAs are required for m6A regulation in renal cell carcinoma (RCC) remains unclear. Meta‐analysis and bioinformatics identified that IGF2BP3 was upregulated in RCC and indicated a worse prognosis. IGF2BP3 significantly promoted RCC progression in vitro and in vivo. Mechanistically, circRARS bound to KH1–KH2 domains of IGF2BP3 to enhance m6A modification recognition. A 12‐nt sequence (GUCUUCCAGCAA) was proven to be the IGF2BP3‐binding site of circRARS. Additionally, CAPN15, CD44, HMGA2, TNRC6A and ZMIZ2 were screened to be the target genes regulated by the IGF2BP3/circRARS complex in an m6A‐dependent manner. Stabiliser proteins, including HuR, Matrin3 and pAbPC1, were recruited by circRARS, thereby increasing the mRNA stability of the forementioned five target genes. Consequently, the IGF2BP3/circRARS complex facilitated the lipid accumulation of RCC cells and promoted sunitinib resistance via target genes. circRARS synergised with IGF2BP3 to facilitate m6A recognition, thereby promoting RCC progression. Thus, IGF2BP3 could be a potential biomarker for RCC diagnosis and prognosis and a therapeutic target.
Exploring the potential of radiolabeled duramycin as an infection imaging probe
Authors: Kumar Anuj , Mitra Jyotsna Bhatt , Khatoon Elina , Pramanik Aparna , Sharma Rohit K. , Chandak Ashok , Rakshit Sutapa , Mukherjee Archana 
Published: December 2023

AbstractThe continuous pursuit of designing an ideal infection imaging agent is a crucial and ongoing endeavor in the field of biomedical research. Duramycin, an antimicrobial peptide exerts its antimicrobial action on bacteria by specific recognition of phosphatidylethanolamine (PE) moiety present on most bacterial membranes, particularly Escherichia coli (E. coli). E. coli membranes contain more than 60% PE. Therefore, duramycin is an attractive candidate for the formulation of probes for in situ visualization of E. coli driven focal infections. The aim of the present study is to develop 99mTc labeled duramycin as a single‐photon emission computed tomography (SPECT)‐based agent to image such infections. Duramycin was successfully conjugated with a bifunctional chelator, hydrazinonicotinamide (HYNIC). PE specificity of HYNIC‐duramycin was confirmed by a dye release assay on PE‐containing model membranes. Radiolabeling of HYNIC–duramycin with 99mTc was performed with consistently high radiochemical yield (>90%) and radiochemical purity (>90%). [99mTc]Tc‐HYNIC‐duramycin retained its specificity for E. coli, in vitro. SPECT and biodistribution studies showed that the tracer could specifically identify E. coli driven infection at 3 h post injection. While 99mTc‐labeled duramycin is employed for monitoring early response to cancer therapy and cardiotoxicity, the current studies have confirmed, for the first time, the potential of utilizing 99mTc labeled duramycin as an imaging agent for detecting bacteria. Its application in imaging PE‐positive bacteria represents a novel and promising advancement.
Performance evaluation and optimization of solar dish concentrator in the upper Egypt region
Authors: Mohammed Ahmed H. , Shmroukh Ahmed N. , Ghazaly Nouby M. , Kabeel Abd Elnaby 
Published: December 2023

AbstractThe goal of this study is to optimize and examine the effect of different rim angles and focus lengths on the performance of a solar parabolic dish. To achieve these goals, a solar parabolic dish concentrator was constructed with different focus point positions and tested under the climatic conditions of the Upper Egypt region in Qena city, with the location of (Latitude: 26.16°, Longitude: 32.71°). The preliminary experimental days started on 18th and lasted on 20th of September 2022, and the tested rim angles were 70°, 80°, and 60°. The results showed that the performance of the proposed solar parabolic dish concentrator was enhanced when the rim angle was between 60° and 70°, otherwise, the performance was regressed when the rim angle was between 70° and 80°. To optimize the rim angle, another available rim angle was selected to increase the performance of the solar dish fixed at 65°, and this angle was tested on 21st of September 2022. The results demonstrated that the thermal efficiency of the solar parabolic dish with rim angle of 65° was higher than that of 70°, 80°, and 60°, and the recorded thermal efficiency reached up to 79.5%, 39.4%, 5.84%, and 28.4%, respectively, under the tested rim angles.
Energy, exergy, economic, exergoeconomic, exergoenvironment, and enviroeconomic (6E) analysis of solar stills—A critical review
Authors: Maurya Ashish , Kumar Ravinder , Gupta Aveek , Ahmadi Mohammad Hossein , Al‐Bahrani Mohammed 
Published: December 2023

AbstractDrinking water is a crucial need for human survival and solar stills (SSs) have emerged as a cost‐effective solution to meet this need from an economic point of view. In this work, the working of various SSs, their productivity factors, and various devices that can be integrated to improve their efficiency have been studied. The conversion of saline water into freshwater water using SSs has the potential to address the issue of drinking water. This study highlights the importance of SSs as a viable and sustainable solution for drinking water access. On the basis of various parameters correlating to the performance of the SSs, energy, exergy, economics, exergoeconomics, exergoenvironment, and enviroeconomics analysis has been analyzed in this study. To improve the performance and sustainability of SSs, various combinations were studied. These combinations include SSs with different nanoparticle coatings, phase‐change materials, photovoltaic modules, external condensers, wick materials, and reflectors. It is concluded that a comprehensive framework that integrates thermodynamic, economic, and environmental criteria can guide the development of more efficient and sustainable SS technologies.
Fabricating Quasiperiodic Tilings with Thermal‐Scanning Probe Lithography
Authors: Chandler Liam , Barker Oliver J. , Wright Alexander J. , O'Brien Liam , Coates Sam , McGrath Ronan , Lifshitz Ron , Sharma Hem Raj 
Published: December 2023

AbstractWe outline an approach to fabricate nanoscale artificial quasiperiodic tilings with thermal‐scanning probe lithography. Quasiperiodic tilings such as the Ammann‐Beenker, Square Fibonacci tiling, and Penrose are fabricated and imaged with thermal‐conductance feedback microscopy, followed by electron microscopy. The design implementation, chemical, and physical challenges involved in fabricating such artificial systems using nanolithography are discussed. Additionally, the potential applications of fabricated quasiperiodic tilings are explored.
U.S. economic uncertainty shocks and extreme capital flows episodes: An empirical analysis of emerging and developing economies
Authors: Du Xinqian , Pu Tian 
Published: December 2023

AbstractWe use the two‐way fixed‐effect panel logit model to examine the impact of U.S. economic uncertainty shocks on the probability of extreme capital flow episodes based on quarterly data from 71 emerging and developing economies from 1998Q1 to 2022Q4. According to the findings, U.S. economic uncertainty shocks has a negative effect on the probability of gross capital surges, gross capital flight, and net capital surges, and has a positive effect on the probability of gross capital sudden stops, gross capital retrenchment, and net capital sudden stops. Moreover, we find differences in the factors affecting net and gross capital flows, which are usually more closely related to earnings factors dominated by real economic growth rates. Additionally, the sample's heterogeneity is analysed in accordance with the exchange rate regimes. Our results differ from traditional views, as floating exchange rates do not act as a buffer against extreme capital flows. Finally, capital flows are classified into direct investment, other investment, and portfolio investment, and it is found that U.S. economic uncertainty shocks have a significant impact on the extreme flow episodes of other and portfolio investment.
Time‐varying causality between investor sentiment and oil price: Does uncertainty matter?
Authors: Nakhli Mohamed Sahbi , Mokni Khaled , Youssef Manel 
Published: December 2023

AbstractWhile the oil market‐investors sentiment (IS) has been considerably investigated, almost all studies have focused on the assumption of a constant relationship, and no attention has been given to the causality analysis in a time‐varying approach. To fill this gap, this study investigates the predictive power between IS and oil price based on a time‐varying Granger causality test. Using data over the period 1987–2020, we find evidence of significant bidirectional asymmetric time‐varying causal influences between investor sentiment and oil prices, suggesting that oil prices may predict investor sentiment and vice versa. Besides, the results suggest that bearish (bullish) investor sentiment has positive (negative) influences on oil prices during major economic and political events. In contrast, oil price exerts an influence on the sentiment which switches between positive and negative from one period to another. Further analysis shows that uncertainty related to the oil and equity markets can be a driver of the predictive power of oil prices on the bearish IS.
Clinical applications of fibroblast activation protein‐targeted theranostics in oncologic and nononcologic disease: Current status and future directions
Authors: Fu Hao , Guo Wei , Huang Jingxiong , Wu Hua , Chen Haojun 
Published: December 2023

AbstractQuinoline‐based fibroblast activation protein (FAP) inhibitor (FAPI)‐based positron emission tomography (PET) imaging and radioligand therapy (RLT) are being investigated for use in a wide variety of diseases, and recent results have been promising. This review summarizes the current status of FAPI radiopharmaceuticals in PET imaging of malignant tumors and benign conditions and compares their diagnostic efficacy with 18F‐fluorodeoxyglucose. In addition, we summarize the previously published FAP‐targeted RLT data and discuss its current clinical use and future potential. Our qualitative summary can inform future research directions, medical guidelines, and optimal clinical decision‐making.
HbA1c of 5.8% or higher as the most useful indicator for recommendation of ultrasonography to detect nonalcoholic fatty liver disease
Authors: Tatsuta Miwa , Ono Masafumi , Kimura Shungo , Zuigyo Kaori , Sato Yudai , Tomida Akemi , Kobayashi Mitsuyoshi , Yoshikawa Ritsuko , Murao Satoshi , Tani Joji , Morishita Asahiro , Kobara Hideki , Himoto Takashi , Maeta Tsuyoshi , Mori Yoshihiro , Kohi Fumikazu , Masaki Tsutomu 
Published: December 2023

AbstractBackground and AimNonalcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome. This study was performed to examine the association between NAFLD and each factor of metabolic syndrome and to identify the factors that are most strongly associated with NAFLD in participants undergoing health checkups.MethodsWe studied 6538 participants who underwent a health checkup from 2017 to 2018 in our institution. Participants with alcohol intake exceeding 20 g/day or with other chronic liver diseases were excluded. Fatty liver was detected by ultrasonography.ResultsIn total, 4310 participants were enrolled, and 28.4% had fatty liver (NAFLD). The prevalence of NAFLD was highest in the diabetes mellitus (DM)‐only group than in the dyslipidemia‐only or hypertension‐only group. The DM‐only group was the only group whose prevalence of NAFLD was >50% in the overall study and in males. The prevalence of NAFLD was higher in males than in females in the DM‐only, hypertension‐only, and dyslipidemia‐only groups. The prevalence of NAFLD was >70% in the dyslipidemia and DM combined group. Multivariate analysis showed that gender and HbA1c were the independent factors most strongly associated with NAFLD. The cutoff value for HbA1c by receiver operating characteristic curve analysis was 5.8% (sensitivity, 57.9%; specificity, 72.6%; area under the curve, 0.70).ConclusionNAFLD was most strongly associated with DM, among the various components of metabolic syndrome. We strongly recommend abdominal ultrasonography to detect NAFLD in patients with an HbA1c of ≥5.8% in general practice and during health checkups.
Shatianyu dietary fiber (Citrus grandis L. Osbeck) promotes the production of active metabolites from its flavonoids during in vitro colonic fermentation
Authors: Deng Mei , Ye Jiamin , Zhang Ruifen , Zhang Shuai , Dong Lihong , Huang Fei , Jia Xuchao , Su Dongxiao , Ma Qin , Zhao Dong , Zhang Mingwei 
Published: December 2023

AbstractBACKGROUNDRecent studies reveal that dietary fiber (DF) might play a critical role in the metabolism and bioactivity of flavonoids by regulating gut microbiota. We previously found that Shatianyu (Citrus grandis L. Osbeck) pulp was rich in flavonoids and DF, and Shatianyu pulp flavonoid extracts (SPFEs) were dominated by melitidin, obviously different from other citrus flavonoids dominated by naringin. The effects of Shatianyu pulp DF (SPDF) on the microbial metabolism and bioactivity of SPFEs is unknown.RESULTSAn in vitro colonic fermentation model was used to explore the effects of SPDF on the microbial metabolism and antioxidant activity of SPFEs in the present study. At the beginning of fermentation, SPDF promoted the microbial degradation of SPFEs. After 24 h‐fermentation, the supplemented SPFEs were almost all degraded in SPFEs group, and the main metabolites detected were the dehydrogenation, hydroxylation and acetylation products of naringenin, the aglycone of the major SPFEs components. However, when SPFEs fermented with SPDF for 24 h, 60.7% of flavonoid compounds were retained, and SPFEs were mainly transformed to the ring fission metabolites, such as 3‐(4‐hydroxyphenyl) propionic acid, 3‐phenylpropionic acid and 3‐(3‐hydroxy‐phenyl) propionic acid. The fermentation metabolites of SPFEs showed stronger antioxidant activity than the original ones, with a further increase in SPDF supplemented group. Furthermore, SPFEs enriched microbiota participating in the deglycosylation and dehydrogenation of flavonoids, while co‐supplementation of SPDF and SPFEs witnessed the bloom of Lactobacillaceae and Lactobacillus, contributing to the deglycosylation and ring fission of flavonoids.CONCLUSIONSDPF promote SPFEs to transform to active metabolites probably by regulating gut microbiota. © 2023 Society of Chemical Industry.
Patterning of RAFT Polymer Networks by Laser Deactivation
Authors: Bainbridge Chris William Anderson , Neradt Max , Avzalova Albina , Broderick Neil , Jin Jianyong 
Published: December 2023

AbstractReversible addition‐fragmentation chain‐transfer (RAFT) polymer networks grow in interest due to their living and tunable characteristics. An essential step toward exploiting these characteristics is the production of precise patterns for growth. Herein, a novel, straightforward strategy to produce patterns to control growth on RAFT‐based living polymer networks (LPNs) is presented. A 405 nm laser is used to degrade the RAFT agents in selected regions, generating a pattern. This occurs through homolytic photocleavage at the C─S bond, leading to the typical RAFT equilibrium state with the R‐group radical and a thiyl radical species, followed by irreversible loss of CS2 to produce a Z‐group derived thiol. Using this technique, both “on/off” patterns and more detailed greyscale patterns are produced using images of varying complexity. Post production growth then shows that these patterns are visually retained after iniferter growth with a fluorescent monomer. Due to the deactivation of selected RAFT agents, the authors are able to perform discriminate growth with network‐wide irradiation. This selective degradation technique serves as an alternative technique for producing patterns on RAFT LPNs.
Spatio‐temporal risk analysis of agriculture and meteorological droughts in rainfed Potohar, Pakistan, using remote sensing and geospatial techniques
Authors: Goheer Muhammad Arif , Aftab Bibi , Farah Humera , Hassan Sher Shah 
Published: December 2023

AbstractDroughts of various types are considered as a major threat to rainfed agriculture, because agricultural production is dependent on the spatio‐temporal distribution of rainfall. The rainfed regions of Pakistan, such as Potohar, have experienced several instances of drought since 2000. The most drought‐affected staple crop of the region is wheat, which ultimately affects regional food security. In this study, we examine the agricultural and the meteorological droughts in the Potohar region during 2000–2020, to create a drought risk map. This region comprises four districts, namely Attock, Chakwal, Jhelum and Rawalpindi. First, the agricultural and meteorological drought severity maps were created using rainfall data (meteorological data) and vegetation indices for three different periods (i.e., drought year, moderate drought year and normal year). The agricultural drought patterns and intensity were identified and evaluated using the MODIS products MOD09A1 and MOD11A2, while the meteorological droughts were identified using CHRIPS rainfall data. Afterwards, a combined drought risk map was generated by integrating the agricultural and meteorological adrought severity maps using a weighted overlay analysis. This drought risk map showed that Attock and Rawalpindi were expeiencing slight to no drought conditions, whereas the southwestern and central parts of Chakwal showed moderate drought conditions. Similarly, the western parts of Jhelum faced moderate drought conditions. Thus, the combined drought risk map may be a useful guide for decision makers in the local and provincial government. Using this map, they can identify adaptation practices in the drought‐prone areas of this region for enhancing agricultural productivity.
High‐throughput experimental techniques for corrosion research: A review
Authors: Ren Chenhao , Ma Lingwei , Zhang Dawei , Li Xiaogang , Mol Arjan 
Published: December 2023

AbstractHigh‐throughput experimental techniques can accelerate and economize corrosion evaluation, and thus, have great potential in the development of new materials for corrosion protection such as corrosion‐resistant metals, corrosion inhibitors, and anticorrosion coatings. This concise review highlights high‐throughput experimental techniques that have been recently applied for corrosion research, including (i) the high‐throughput preparation of metal samples in the form of thin films or bulk materials, (ii) high‐throughput experiments based on corrosive solutions with independent or gradient parameters, (iii) high‐throughput evaluation of changes in physicochemical properties, and (iv) high‐throughput corrosion evaluation by electrochemical methods. To advance automated and intelligent corrosion research, future directions for the development of the high‐throughput corrosion experimental and characterization techniques are also discussed.
Evaluating methods of detecting and determining the type of urinary incontinence in adults after stroke: A systematic review
Authors: Gordon Clare , Davidson Catherine Emma , Roffe Christine , Clegg Andrew , Booth Joanne , Lightbody Catherine Elizabeth , Harris Catherine , Sohani Amin , Watkins Caroline 
Published: December 2023

AbstractIntroductionUrinary incontinence (UI) affects over half of people with stroke. It is unclear which methods are accurate in assessing presence and type of UI to inform clinical management. Diagnosis of UI based on inaccurate methods may lead to unnecessary interventions. The aims of this systematic review were to identify, for adults with stroke, clinically accurate methods to determine the presence of UI and type of UI.MethodWe searched seven electronic databases and additional conference proceedings. To be included, studies had to be primary research comparing two or more methods, or use a reference test.ResultsWe identified 3846 studies with eight eligible for inclusion. We identified 11 assessment methods within the eight studies. Only five studies had sufficient comparator data for synthesis. Due to heterogeneity of data, results on the following methods were narratively synthesized: Core Lower Urinary Tract Symptom Score (CLSS), clinical history and physical examination, Barthel Activities of Daily Living Index, International Consultation Incontinence Questionnaire Short Form (ICiQ‐SF) and urodynamic studies (UDS). Most studies were small and of low to medium quality. All reported differences in sensitivity, and none compared the same assessment methods.ConclusionCurrent evidence is insufficient to support recommendations on the most accurate UI assessment for adults with stroke. Further research is needed.
Evaluation of new treatments for benign prostatic obstruction: ICI‐RS 2023
Authors: Hashim Hashim , Tarcan Tufan , Acar Omer , Malde Sachin , Wein Alan , Abrams Paul 
Published: December 2023

AbstractAimsTo address how invasive therapies for benign prostatic obstruction (BPO) have been evaluated, what their effect is on BPO, if they can prevent progression to BPO and how new therapies need to be evaluated before implementation into clinical practice.MethodsThe think tank conducted a literature review and looked at the previous and current American Urological Association, European Association of Urology and the International Consultation on Urological Diseases guidelines to see what procedures have been used to treat BPO. They then assessed whether trials have been conducted before implementation of the procedures and whether they have been compared to a “gold” standard treatment. The use of urodynamics has also been addressed in the think tank in relation the clinical trials as well as terminology.ResultsGuidelines vary in the use of terminology when it comes to BPO with some continuing to use the term benign prostatic hyperplasia (BPH). There are several procedures for example, TUNA, which have become obsolete although continues to be mentioned in the guidelines until recently. Majority of procedures have been introduced without comparing to “gold” standard treatment and without any long‐term data. There continues to be many unknowns with regard to the success of some of the BPO procedures and why some of the adverse events develop.ConclusionThere needs to be more robust long‐term clinical trials conducted of new BPO therapies, with men who have both lower urinary tract symptoms and urinary retention, before introduction into clinical practice.