bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encapsulated Probiotic Microorganisms in Functional Food Products
Authors: Starovoitova S.O. , Kishko K.M. , Demchenko O.M. , Bila V.V. 
Published: December 2023

Alterations in the composition of the gut microbiota are associated with a wide range of pathologies, including not only inflammatory diseases of the gastrointestinal tract, but also diabetes, obesity, cancer, and diseases of the cardiovascular and central nervous systems. With an imbalance of the microbiota (dysbiosis), there is increased intestinal permeability and a violation of local or systemic immune responses. One of the possible ways to improve intestinal microbiota is the use of dietary supplements and functional food products enriched with highly effective encapsulated probiotic microorganisms, as well as prebiotic compounds. Such products contribute to the restoration of normal intestinal microflora and its integrity, and also indirectly affect the positive outcome in the treatment of many pathological conditions mediated by an imbalance in the intestinal microbiota. Maintaining the activity of probiotics in food carriers or functional food products designed for the prevention and complex therapy of various pathological conditions is important both for the normalization of the intestinal microflora and the health of the body as a whole. In this context, encapsulation is an effective approach to maintain the viability and stability of probiotics under adverse conditions in the gastrointestinal tract and also an effective way to protect from processing conditions, temperature, and transportation. The development of functional nutrition products enriched with highly effective encapsulated probiotic microorganisms is a priority for new research in the field of prevention and treatment in microbiota-targeted therapy. The use of such products is based on the conception of 3p — pathophysiology-based individualized use of probiotics and prebiotics in various pathological conditions mediated by a violation of the qualitative and/or quantitative composition of the intestinal microbiota: implementing a predictive, preventive, and personalized medical approach.
Natural aging and vacancy trapping in Al-6xxx
Authors: Jain Abhinav C. P. , Ceriotti M. , Curtin W. A. 
Published: December 2023

AbstractUndesirable natural aging (NA) in Al-6xxx delays subsequent artificial aging (AA) but the size, composition, and evolution of clustering are challenging to measure. Here, atomistic details of early-stage clustering in Al–1%Mg–0.6%Si during NA are studied computationally using a chemically-accurate neural-network potential. Feasible growth paths for the preferred $$\beta ''$$

β

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precipitates identify: dominant clusters differing from $$\beta ''$$

β

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motifs; spontaneous vacancy-interstitial formation creating 14–18 solute atom $$\beta ''$$

β

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-like motifs; and lower-energy clusters requiring chemical re-arrangement to form $$\beta ''$$

β

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nuclei. Quasi-on-lattice kinetic Monte Carlo simulations reveal that 8–14 solute atom clusters form within 1000 s but that growth slows considerably due to vacancy trapping inside clusters, with trapping energies of 0.3$$-$$
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0.5 eV. These findings rationalize why cluster growth and alloy hardness saturate during NA, confirm the concept of “vacancy prisons”, and suggest why clusters must be dissolved during AA before formation of $$\beta ''$$

β

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′

. This atomistic understanding of NA may enable design of strategies to mitigate negative effects of NA.
Graphical abstract
Energy and RMS vacancy displacement vs simulation time for three different kMC simulations of Al matrix containing Mg (green) and Si atoms(orange), and 1 vacancy (pink). Geometries extracted from the third trajectory at four different times show solute clustering and vacancy trapping.
Te enseñaré a las buenas
Authors: Álvarez-Campos Harold 
Published: December 2023

La educación es tan apasionante que todos, alguna vez hemos enseñado a hijos, hermanos, parientes y extraños (compañeros de curso), solo por tener la oportunidad de obtener la experiencia que esta brinda o porque nos sentimos cómodos al momento de orientar una explicación. Es así como me decidí un día, desprendiéndome un poco del temor a salir en cámara y observando las bondades de las herramientas que ofrece la tecnología informática para con los procesos académicos, a producir una serie que recogía los más variados temas que hacían parte de una metodología de enseñanza a las buenas, y que organicé en 16 capítulos bajo el título de la Serie “Te enseñaré a las buenas”, la cual está disponible en el canal “Harold Álvarez – BrillanTeacher” en YouTube, y cubren temas como motivación en el aula, organizadores gráficos, el sonido en el aula, uso de avatares, entre otros temas. Ah, y se me olvidaba que me acompañará Morita (la mascotica de mi nena angelina), en el relato de esta maravillosa profesión como lo es la docencia.
¡Camine pues y métete en la película, porque esto es una película!
La Didáctica de la Literatura en la Escuela Primaria
Authors: Peña-García Sibele Nadalya 
Published: December 2023

En este trabajo de investigación se muestran los antecedentes de la didáctica de la literatura en el proceso de educación a través de diferentes autores para luego contrastar dicha información con la práctica actual de las obras literarias en las aulas por medio de un análisis estadístico de las variables correspondientes. La encuesta diseñada para dicho análisis, es aplicada a través de la aplicación del formulario del programa de Office 365. La muestra de alumnos que respondieron a la encuesta fue de 174 niños y niñas de sexto grado de educación primaria de la ciudad de Saltillo, Coahuila México. El diseño metodológico para esta investigación es de tipo descriptiva y deductiva, con un enfoque mixto. En los antecedentes del tema se destaca que durante el siglo XX el aprendizaje principal de la lectura han sido los textos funcionales y el dominio de los diferentes géneros discursivos propios de la vida en sociedad, pero quedaba en un plano secundario ante los textos informativos; esto, llevado finalmente a trabajar el texto literario como un simple soporte de actividades lingüística. Como parte de los resultados se obtiene, que el desarrollo de competencias lectoras y la adquisición del hábito por la literatura, se reafirma por medio de la lectura frecuente y comentada en el aula, entre amigos y en familia; los textos literarios se disfrutan y aprovechan más cuando se analiza su contenido, se estimula la imaginación y se relaciona con la vida misma al interactuar con los diferentes géneros literarios en el aula con la orientación pertinente del docente y la implementación de estrategias de aprendizaje contextualizadas en la comunidad educativa.
Changes of vascular stiffness and central blood pressure after endovascular aneurysm repair in patients with hypertension. Results of one-year follow-up
Authors: Gurevich A. P. , Emelyanov I. V. , Ionov M. V. , Vanyurkin A. G. , Chernyavsky M. A. , Conradi A. O. 
Published: December 2023

Aim. To assess the changes of arterial stiffness, central blood pressure (CBP), and determine the factors potentially influencing them in patients with descending thoracic and abdominal aortic aneurysm, in combination with hypertension, one year after endovascular aneurysm repair ((T)EVAR).Material and methods. Patients ≥18 years of age without clinically significant cardiac arrhythmias were included. Before surgery and a year later, we determined peripheral blood pressure, heart rate (HR), CBP, augmentation index (AIx), pressure at the point of maximum rise of the direct pulse wave (PT1h), time to return of the reflected pressure wave (Tr) and carotid femoral pulse wave velocity (cfPWV).Results. Fifty patients were included (mean age, 68±9 years; 41 men; 16 with descending thoracic aortic aneurysm, 34 with abdominal aortic aneurysm), 23 patients were reexamined. After (T)EVAR, an increase in cfPWV (+2,6 m/s, p<0,001), PT1h (+5 mm Hg, p=0,026), peripheral pulse pressure (+7 mm Hg, p=0,039), heart rate (+5 beats/min, p=0,025). The CBP and AIx values have not changed. The dependence of Tr decrease on the stent-graft length (β=0,42) and the decrease in heart rate (β=-0,52) was found. During the year, 6 cardiovascular events were registered.Conclusion. Graft implantation is accompanied by an increase in cfPWV, regardless of aneurysm location. An increase in PT1h one year after (T)EVAR may reflect a decrease in aortic distensibility and worsening damping function. No changes of CBP and AIx is probably explained by reflected wave characteristics after surgery. Predictors of Tr are — increase in heart rate and implantation of longer stent grafts.
Effectiveness of buffered acetylsalicylic acid compared to other drugs in diseases patients in clinical practice: results of the CARDINAL observational retrospective study
Authors: Kobalava Zh. D. , Tolkacheva V. V. , Kaftanov A. N. , Gavrilov D. V. 
Published: December 2023

Aim. To evaluate the effectiveness of acetylsalicylic acid (ASA) drugs for secondary prevention of atherosclerotic cardiovascular disease (ASCVD) in clinical practice and compare the effectiveness of the Cardiomagnyl with other ASA drugs.Material and methods. This observational, non-interventional, retrospective study included data from electronic medical records of 18199 patients with ASCVD who were divided into 2 following groups: patients who received ASA 75-100 mg (n=9784) and patients who did not receive ASA (n=8325). The prescription rate of ASA, the choice of the first drug, the duration of ASA therapy, the frequency of switching ASA during treatment, and the choice of the second ASA drug when changing therapy were assessed. Due to the heterogeneity of patients in the above groups, to assess the clinical outcomes, propensity score matching was performed and comparable groups were selected to evaluate the effectiveness of ASA drugs 75-100 mg in patients with ASCVD (n= 427) in comparison with patients not receiving ASA (n=427) and to assess the effectiveness of Cardiomagnyl 75 mg (n=1308) in comparison with enterosoluble ASA 100 mg (CRA) (n=1308) taking into account 24 parameters.Results. The average proportion of patients with ASCVD taking ASA drugs was 58%. During treatment, 54% of patients underwent a change in drug therapy from one ASA drug to another. The prescription rate of Cardiomagnyl as a first-choice drug was 33%, and as a second drug when changing therapy — 21%. The duration of Cardiomagnyl therapy was the longest compared to other ASA drugs and amounted to 16,3 months. The incidence of ischemic stroke, myocardial infarction and major adverse cardiovascular events in the group of patients who received ACS 75-100 mg was significantly lower than in patients who did not take ASA drugs and amounted to 4,7% vs 8,7%, 0,9% vs 3,3%, 5,6% vs 11,9%, respectively. Significantly lower incidence of unstable angina (0,8% vs 2,0%), myocardial infarction (1,5% vs 3,9%) and major adverse cardiovascular events (5,4% vs 7,8%) in group of patients who received Cardiomagnyl 75 mg as opposed to enterosoluble ASA.Conclusion. Significant advantages of buffered ASA (Cardiomagnyl) were revealed in comparison with enterosoluble ASA in clinical practice.
Cost-effectiveness of valsartan+sakubitril, dapagliflosin and empagliflosin for prevention of cardiovascular death and reducing cardiovascular mortality within the State Program "Health Development" in patients with heart failure
Authors: Zhuravleva M. V. , Tereshchenko S. N. , Paleev F. N. , Gagarina Yu. V. , Shabalina E. A. 
Published: December 2023

Aim. To assess cost-effectiveness of valsartan+sakubitril, dapagliflosin and empagliflosin for prevention of cardiovascular death and achieving the target indicator "reduction of cardiovascular mortality" of the State Program "Health Development" in patients with heart failure (HF) of the entire profile of left ventricular ejection fraction in 2023-2024Material and methods. The target population was Russian patients who had acute cardiovascular disease (CVD) and a verified diagnosis of HF and received subsidized drug coverage. Parametric modeling was used to predict cardiovascular mortality. In the corresponding comparative pair, the amount of drug costs required to prevent one cardiovascular death (CVD) was calculated, as well as to achieve a 1% target for reducing cardiovascular mortality in the whole country and separately in each region.Results. To prevent one cardiovascular event, the costs of 1-year val-sartan+sacubitril therapy was RUB11,80 million, dapagliflozin — RUB7,07 million, empagliflozin — RUB13,83 million. The costs required to achieve a 1% target for reducing cardiovascular mortality for valsartan+sacubitril, dapagliflozin and empagliflozin were:• in 2023, RUB6534,0 million, RUB3915,0 million and RUB7654,2 million, respectively;• in 2024, RUB1100,6 million, RUB659,5 million and RUB1289,7 million, respectively.Conclusion. The use of dapagliflozin is characterized by the lowest costs for preventing one cardiovascular event and achieving a 1% target for reducing cardiovascular mortality in 2023-2024.
History of Economic Thought in the Labyrinth of Historiographical Approaches
Authors: Maidachevsky Dmitry 
Published: December 2023

The article attempts to trace the metamorphoses that the domestic historiography of economic science has undergone from perestroika to the present day. The “paradigm of replacement” adopted by the supporters of perestroika, together with the “water” of ideology and presentism of orthodox Marxism, also splashed out the “child” — the methodological principles of historicism and empiricism, forcing historiography to follow in the wake of the approaches of the Western “mainstream”. Having fallen, along with the latter, into the trap of presentism of the “history of economic analysis”, having experienced the “loss of institutional viability”, historiography (more precisely, what was left of it) at the end of the road found refuge in the symbolic reality of “intellectual history”. True, at the cost of losing not only historicism, but also disciplinary identity (economic orientation) and its scientific character. As a result of the study, the author comes to the conclusion that the return of the lost methodological principles of historical realism and empiricism, interest in the content of economic knowledge and its analysis will be facilitated by turning to the historical-scientific historiographic approach, which not only follows the standards of professional historical science, but and using a dictionary, as well as theoretical models of the sociology of scientific knowledge, which set the conceptual framework for historical and scientific studies.
Bone defect management with tissue-engineered constructs based on deproteinized cancellous bone: an experimental study
Authors: Anastasieva E. A. , Cherdantseva L. A. , Tolstikova T. G. , Kirilova I. A. 
Published: December 2023

Background Management of bone defects with autologous bone grafting has always been the "gold standard" but it is not always possible to use it for a number of reasons. Preprocessed materials of biological and non-biological origin were developed as an alternative. A new branch of these materials is tissue-engineered constructs that fully imitate autologous bone in required volume.Aim is to study in vivo the possibility of using deproteinized human cancellous bone tissue as a matrix for creating tissue-engineered constructs.Methods The study was carried out on 24 NZW line rabbits, since this line has a fully characterized stromal-vascular fraction formula (SVF). The study design included 3 groups. First group (control) had surgical modeling of bone defects in the diaphysis of the contralateral femur without reconstruction; Group 2 had bone defect reconstruction using fragments of a deproteinized cancellous bone graft; group 3 underwent bone defect reconstruction using fragments of deproteinized cancellous bone matrix along with the autologous adipose tissue SVF (obtained according to ACP SVF technology). Animals were sacrificed with ether anesthesia at 2, 4 and 6 weeks after the operation and subsequent histological study followed.Result During all periods of the study, the newly formed bone tissue volume density in the 3rd group (reconstruction with deproteinized human cancellous bone + stromal-vascular fraction) was 1.78 times higher (p < 0.001) than in the first group (bone defect without reconstruction), 1.21 times higher (p < 0.001) than in the 2nd group (reconstruction with deproteinized cancellous bone alone). The dynamics of changes in the mature bone tissue volume density was similar to those of the newly formed bone tissue.Discussion The comparative analysis of reparative processes using a tissue engeneered construst based on deproteinized cancellous human bone with adipose tissue stromal vascular fraction revealed that the use of these bone substitute materials contributes not only to the early activation of reparative regeneration of the main structural elements of bone tissue at the site of bone defect, but also their timely differentiation.Conclusion The use of deproteinized cancellous bone matrix combined with stromal-vascular fraction to create a tissue-engineered construct could unleash several regeneration mechanisms and accelerate the process of bone defect site repair, compared with 1st and 2nd group of study.
Aneurismal bone cyst of the medial cuneiform bone: a case report of a new surgical approach and literature review
Authors: Leonchuk S. S. , Punit T. 
Published: December 2023

Introduction An aneurysmal bone cyst (ABC) is a rare, non-neoplastic, destructive, hemorrhagic, and expansile lesion accounting for 1 % of all bone tumors. ABC of the foot is very rare. Patients with foot ABC usually complain of pain and swelling of the affected area. Radiographs and MRI may be helpful in the diagnosis of ABC. No single surgical procedure has gained wide acceptance in the treatment of foot ABC.Purpose To show new effective surgical approach in the treatment of patient with ABC of the medial cuneiform bone.Material and methods We present the case of a 47-year-old woman with a 10-months history of pain and swelling in her right foot. Postoperative histopathological evaluation of resected tissues confirmed the diagnosis of ABC. An en bloc resection (total extraction of the remnant of the medial cuneiform bone) was performed and the defect was replaced with a fibular bone graft from the right leg. Allograft (Bio-Ost®) was placed along the autograft. Tibialis anterior tendon was attached to the fibular bone graft. We performed fixation of the foot and ankle using the Ilizarov original apparatus for prevention of bone graft instability and opportunity for early weight-bearing on the operated foot.Results The postoperative period was uncomplicated with complete healing of the bone defect without recurrence after 12 months of observation. AOFAS score increased significantly from 34 points preoperatively to 92 at 1-year follow-up.Discussion The optimal treatment of this lesion is still under discussion. Different treatment modalities have been described in the literature: wide resection, curettage with or without adjuvants, arterial embolization, intralesional sclerotherapy. Biological reconstruction using bone graft seems to be the best option, but fractures and nonunion are common complications of bone grafting.Conclusion The combination of Ilizarov external fixation and bone grafting provided favorable conditions for the healing of foot bone defect due to ABC without complications, allowed mobility and early weight-bearing of the patient. Recurrence was not detected radiologically. Harvesting of the fibular bone graft did not affect the position of the foot and its movements. Our surgical approach should be considered as a treatment option in similar cases.
The current state and the mechanism of the transformation of the ESG agenda by Russian companies. Part 2.
Authors: Izmailova M. A. 
Published: December 2023

Purpose: development of a mechanism for the ESG transformation of Russian companies based on a critical assessment of the evolution and modern implementation of the ESG agenda in Russia. In the second part of the article, the author solves the problem of analyzing the compliance of the content of the Russian ESG agenda with global risks and developing a mechanism for the ESG transformation of Russian companies.Methods: methods of theoretical analysis were applied, which made it possible to reveal the conceptual component of the ESG agenda and sustainable development; empirical analysis of the global risk landscape and the implementation of the Russian ESG agenda; a statistical method for determining priority areas for the implementation of the Russian ESG agenda; abstraction and modeling to formalize the ESG transformation mechanism/Results: the conceptualization of the ESG agenda and sustainable development was carried out, the content basis of which harmonizes with corporate social responsibility. The mobility of the landscape of global risks with a steady trend of the prevalence of environmental and social risks is determined. The results of the implementation of the Russian ESG agenda based on the results of 2022 and the tasks for the near future are summarized. Priority directions and barriers to the implementation of the ESG agenda have been established. Proposed mechanism for ESG transformation of Russian companies.Conclusions and Relevance: the functioning of national economies is influenced by global threats: environmental and social risks are leading in the next decade. The results of the implementation of the Russian ESG agenda indicate its adequacy to the nature of global risks. In environmental policy, attention is focused on energy saving and waste recycling technologies, in social policy - on social guarantees and support for the professional and personal development of employees, in corporate policy - on consumer surveys and selection of suppliers. Among the barriers to the implementation of the ESG agenda: financial, associated with fears of non-return of investments and high costs for the ESG agenda; methodical, manifested in the absence of uniform standards and ESG indicators; lack of external incentives and low ESG-competence of management. The low awareness of company management about ESG and how to incorporate it into business processes served as the basis for developing a mechanism for transforming a business model based on ESG principles, including an ESG transformation model, operating principles and required competencies.