bluuebunny/crossref_metadata_2025_split huggingface dataset:
The causal relationship between smoking, alcohol intake, tea intake, coffee intake, and risk of gout: univariate and multivariate Mendelian randomization analysis
Authors: Wang Du , Long Jiaye , Yang Miyang , Pang Yingrong , He Zhiling , Kang Hongyan , Li Zhong 
Published: December 2023

Abstract
Objectives
The precise causal connection between smoking, alcohol consumption, tea consumption, coffee consumption, and gout remains ambiguous. The objective of this article is to investigate the causal connection between smoking, alcohol consumption, tea consumption, coffee consumption, and gout.
Methods
Utilizing univariate and multivariate Mendelian randomization (MR) analyses, the causal relationship between smoking, alcohol consumption, tea consumption, coffee consumption, and gout was investigated. Four supplementary MR techniques were implemented alongside the inverse difference weighted (IVW) method, which served as the primary approach for MR estimation: MR Egger, weighted medium, weighted mode, and simple mode. Furthermore, a multivariate Mendelian randomization analysis was performed to eliminate potential confounding variables that might influence the incidence of gout.
Results
The univariate MR analysis revealed that tea and coffee consumption were associated with a protective causal relationship against gout (OR = 0.13, 95% (confidence interval) CI: 0.03–0.51, P = 0.003; OR = 0.07, 95% CI: 0.01–0.71, P = 0.024). Conversely, smoking and alcohol consumption did not exhibit a causal relationship with gout. A protective causal relationship was observed between tea consumption and gout in a multivariate MR analysis (OR = 0.28, 95% CI: 0.10–0.76, P = 0.012; OR = 0.28, 95% CI: 0.13–0.63, P = 0.002; OR = 0.30, 95% CI: 0.10–0.86, P = 0.025). However, no causal relationship was found between gout and smoking, alcohol consumption, or coffee intake.
Conclusions
Our research findings indicated a potential protective causal relationship between tea consumption and gout.
New pixel-level low-cost Polar Star tracking technique and device for the instantaneous evaluation of atmospheric turbulence (seeing)
Authors: Augusto Pedro , Andrade Ilidio , Lagani Paolo , Conaci Angela 
Published: December 2023

Abstract

Atmospheric turbulence (seeing) transforms a telescope star image into a jumbled mess of light. Seeing has been measured for decades with expensive instrumentation (the cheapest portable versions cost ~10 000€). We recovered the 60-yrs old ‘Walker method’ to expose the Pole Star for five minutes and calculate the seeing using a new technique and device (M.BASE.MATE), the full details of which are given in this paper, including the design, data, and codes. Following the frugal science philosophy, we managed to reduce the cost to ~1000€; we further suggest seeing measurements to be made at sites that we have identified in less developed countries. We tested our method for a full year in Madeira, which is (still) one of the great sites in the world without a professional observatory: sub-arc second seeing three-quarters of the time; average seeing below 0.5 arc seconds (twice better than La Palma in the same period).
Teaser
A new low-cost method for astronomical atmospheric turbulence (seeing) determination is validated at the island of Madeira.
Global and Local Spatial Analysis for the Degradation Rate of Gamma and Neutron Rays in Hiroshima and Nagasaki
Authors: Lotfy Nesma 
Published: December 2023

Abstract
Background
During World War II, Japan experienced significant damage due to the deployment of two atomic bombs in Hiroshima and Nagasaki. However, the degradation rate of the Gamma and Neutron rays, measured using Dosimetry System 1986 (DS86) within around 1.0 km radius from the hypocenter, differ between Hiroshima and Nagasaki. Additionally, the two cities exhibit significant variations in their topography and population density. Therefore, the objective of the present study is to examine the impact of topography and population density on the degradation rate of Gamma.
Methods
Data on topography, population density, and Gamma and Neutron rays in 1945 was acquired from various online resources. A local Wilcoxon test was conducted to examine the differences between Gamma and Neutron degradation rate, as well as differences in Gamma and Neutron degradation rate between Hiroshima and Nagasaki. The Jaccard similarity coefficient was employed to assess the similarity of topography and population density between Hiroshima and Nagasaki. Path analysis, utilizing the GSEM function, was implemented to identify the relationships between topography, population density, and Gamma degradation rate. The study used ArcGIS™ 10.8, R, and STATA 16.0 software.
Results
Observing the degradation rate of Gamma rays emanating from the hypocenter, Hiroshima’s area extends roughly 1.4 km, whereas Nagasaki’s area covers about 1.8 km, with an additional 0.4km region. Concerning the additional area, the Jaccard similarity coefficient between Hiroshima and Nagasaki for topography was calculated to be 0.436, whereas for population density, it measured at 0.685. Regarding path analysis for the additional area, high population density was associated with a better gamma degradation rate (Hiroshima, OR = 0.005; Nagasaki, OR = 0.0014). A high value for topography was associated with a worse gamma degradation rate (OR = 3.52; P = 0.027).
Conclusion
Population density plays an evident role in the Gamma degradation rate. Areas with higher population density exhibit a better degradation rate. On the other hand, regions characterized by challenging topography tend to have lower population density, resulting in a poorer degradation rate, which implies the necessity for additional areas to attain a zero area of rays, consequently giving rise to more health problems.
Unveiling the Impact of 17β-Estradiol on Thymic Epithelial Cell Proliferation: A miRNA Perspective
Authors: Guo Dongguang , Chen Mingyan , He Yaojia , Tian Jinhe , Li Yugu 
Published: December 2023

Abstract
Background Estrogen signaling and microRNA (miRNA) expression play a pivotal role in thymus involution by regulating thymic epithelial cell (TECs) functions. However, the role of Estrogen on miRNA expression in TECs has not been fully elucidated.
Methods Cell proliferation assays, such as the cell-counting kit-8 (CCK-8), 5-Ethynyl-2'-deoxyuridine (EdU) and flow cytometry assays were conducted. Next-generation sequencing (NGS)-based miRNA profiling was performed and validated using Quantitative polymerase chain reaction (qPCR). Additionally, the mechanism of 17β-Estradiol(E2) regulation of miRNA expression in MTEC1 cells was investigated using anti-estrogen ICI 182, 780 and ERα siRNA.
Results A total of 3356 candidate miRNAs across the six miRNA libraries were subjected to analysis, among these, 69 miRNAs displayed notable changes in expression patterns, with 33 miRNAs exhibiting downregulation and 36 miRNAs showing upregulation. Further investigation focused on miR-99a-5p, miR-99b-5p, miR-378a-5p, miR-361-5p, miR-16-5p, and miR-22-3p due to their elevated expression levels. Subsequent examination through Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed a significant association between the dysregulated miRNAs and the functional role of cell proliferation. Furthermore, the regulatory impact of E2 on miRNA expression can be modified by the anti-estrogen ICI 182 780 or inhibited by ERαsiRNA in MTEC1 cells.
Conclusions E2 canalter miRNA expression in TECs, and this miRNA expression may be closely associated with post-transcriptional regulation of cell proliferation in an ERα-dependent manner. Our data indicated the good performance of these miRNAs as potential biomarkers in E2-related thymic involution in TECs.
Optical illusions in different ungulates species
Authors: Berardo Caterina , Holland Ruben , Schaffer Alina , Caicoya Alvaro Lopez , Liebal Katja , Valsecchi Paola , Amici Federica 
Published: December 2023

Abstract
Optical illusions have been used in behavioural studies in recent years to investigate the perceptual mechanisms underlying vision in animals. Although susceptibility to some illusions has been extensively studied in some species, only two studies have yet been carried out in ungulates, suggesting that they may perceive optical illusions in a way similar to humans. Here, we used two food-choice tasks to study susceptibility to the Müller-Lyer and Delboeuf illusions in 17 captive individuals belonging to four ungulate species (Lama guanicoe, Lama glama, Ovis aries, Capra hircus). In control trials, individuals reliably preferred the longer/larger food over the shorter/smaller one. In experimental trials, individuals significantly preferred the food stick between two inward arrowheads over an identical one between two outward arrowheads in the Müller-Lyer task, and they preferred the food on the smaller circle over an identical one on the larger circle in the Delboeuf task, with no significant differences across species. Overall, these findings suggest that, in line with our predictions, ungulates are susceptible to the Müller-Lyer and the Delboeuf illusions in a similar way to humans, and indicate that the perceptual mechanisms underlying size estimation in arctiodactyla might be similar to those of other ungulate and primate species, including humans.
The Conditional Influences of Organizational Climate on the Relationship between the Number and Types of Implementation Strategies and Lupus Decision Aid Acceptability, Appropriateness, and Feasibility
Authors: Hearld Larry , Carroll Nathan , Hall Allyson , Karabukayeva Aizhan , Singh Jasvinder 
Published: December 2023

Abstract
Background: Empirical research is inconsistent regarding the relationship between the number of implementation strategies and the implementation of evidence-based interventions. One potential explanation for inconsistent relationships is an assumption that different types of strategies will have a similar impact on different implementation outcomes. Likewise, relatively little research has considered whether greater (or fewer) numbers of implementation strategies may be more (or less) effective under certain conditions, despite general recognition of the role that implementation strategies can play in overcoming contextual barriers to implementation. The purpose of this paper was to address these gaps by answering three related questions: 1) What is the relationship between the number of implementation strategies and implementation outcomes?; 2) Does the relationship between implementation strategies and implementation outcomes differ for clinic-focused and patient-focused strategies?; and 3) To what extent does the organizational climate strengthen or attenuate the relationship between the number of implementation strategies and implementation outcomes?
Methods: Based on administrative and survey data from 15 U.S. rheumatology clinics that were implementing an evidence-based decision aid for patients with lupus, we used random intercept mixed-effects regression models to examine the association between the total number of implementation strategies (and separately for clinic-focused vs. patient-focused strategies) and clinic staff’ perceptions of decision-aid acceptability, appropriateness, and feasibility. Extensions of the previous models examined whether these relationships were moderated by a clinic’s change readiness and learning climates.
Results: Our analysis suggests that, in aggregate, more strategies do not necessarily result in more positive perceptions of decision-aid acceptability, appropriateness, or feasibility. Additional analyses, however, suggest that the effect of increasing numbers of implementation strategies differ depending on the audience at which the strategy is focused – clinic staff vs. patients. Our moderation analysis also suggests that organizational climate accentuates the relationship between implementation strategies and outcomes in some cases and attenuates the relationship in others.
Conclusions: Collectively, these findings highlight the difficulty of simple, standardized recommendations – e.g., ‘increase the number of implementation strategies’ or ‘clinics should strengthen the readiness or learning climate’. Under some circumstances, increasing the number of implementation strategies may, in fact, have detrimental effects on implementation outcomes.
Trial registration: ClinicalTrials.gov ID: NCT03735238
The Intersection of Parenting and Employment: A Qualitative Exploration of the Experiences of Working Parents
Authors: Adem Bashir Suleiman 
Published: December 2023

Abstract
The primary objective of this research was to delve deeply into the intricate experiences and challenges that arise at the intersection of parenting and employment. It aimed to explore coping mechanisms employed by individuals and investigate the reciprocal impact of employment on parenting. The data collection process involved conducting comprehensive in-depth interviews and structured observations within a working family's household located in the Togdheer region of Somaliland. The study revealed challenges for working parents, such as time constraints, potential child neglect, and a strain on family dynamics due to work commitments. Balancing family life, household responsibilities, and work proved challenging, especially for working mothers. Coping mechanisms included efforts to harmonize work and family duties, seek support, and navigate relationships. The research also explored the reciprocal impact of employment on family dynamics and parenting, revealing both positive and negative effects. Financial stability played a crucial role, and the study highlighted the psychological toll and critical skills needed to juggle diverse responsibilities. Overall, the findings underscore the complex interplay between work, family, and individual well-being. Finally, the research recommended actionable guidance for various stakeholders: Support Systems and Communication: Encouraging working parents to establish dependable family support networks, especially for new working parents. Workplace and Policy Support: Advocating for workplaces to provide comprehensive support for working mothers. Financial Independence and Planning: Promoting the significance of financial independence among working parents, emphasizing premarital discussions to align career and family aspirations, and highlighting the importance of shared financial responsibility within families.
The Evolution of Artificial Intelligence in Biomedicine: Bibliometric Analysis
Authors: Gu Jiasheng , Gao Chongyang , Wang Lili 
Published: December 2023

Background
The utilization of artificial intelligence (AI) technologies in the biomedical field has attracted increasing attention in recent decades. Studying how past AI technologies have found their way into medicine over time can help to predict which current (and future) AI technologies have the potential to be utilized in medicine in the coming years, thereby providing a helpful reference for future research directions.

Objective
The aim of this study was to predict the future trend of AI technologies used in different biomedical domains based on past trends of related technologies and biomedical domains.

Methods
We collected a large corpus of articles from the PubMed database pertaining to the intersection of AI and biomedicine. Initially, we attempted to use regression on the extracted keywords alone; however, we found that this approach did not provide sufficient information. Therefore, we propose a method called “background-enhanced prediction” to expand the knowledge utilized by the regression algorithm by incorporating both the keywords and their surrounding context. This method of data construction resulted in improved performance across the six regression models evaluated. Our findings were confirmed through experiments on recurrent prediction and forecasting.

Results
In our analysis using background information for prediction, we found that a window size of 3 yielded the best results, outperforming the use of keywords alone. Furthermore, utilizing data only prior to 2017, our regression projections for the period of 2017-2021 exhibited a high coefficient of determination (R2), which reached up to 0.78, demonstrating the effectiveness of our method in predicting long-term trends. Based on the prediction, studies related to proteins and tumors will be pushed out of the top 20 and become replaced by early diagnostics, tomography, and other detection technologies. These are certain areas that are well-suited to incorporate AI technology. Deep learning, machine learning, and neural networks continue to be the dominant AI technologies in biomedical applications. Generative adversarial networks represent an emerging technology with a strong growth trend.

Conclusions
In this study, we explored AI trends in the biomedical field and developed a predictive model to forecast future trends. Our findings were confirmed through experiments on current trends.
Patient Experiences and Insights on Chronic Ocular Pain: Social Media Listening Study
Authors: Sloesen Brigitte , O'Brien Paul , Verma Himanshu , Asaithambi Sathyaraj , Parashar Nikita , Mothe Raj Kumar , Shaikh Javed , Syntosi Annie 
Published: December 2023

Background
Ocular pain has multifactorial etiologies that affect activities of daily life, psychological well-being, and health-related quality of life (QoL). Chronic ocular surface pain (COSP) is a persistent eye pain symptom lasting for a period longer than 3 months.

Objective
The objective of this social media listening study was to better understand COSP and related symptoms and identify its perceived causes, comorbidities, and impact on QoL from social media posts.

Methods
A search from February 2020 to February 2021 was performed on social media platforms (Twitter, Facebook, blogs, and forums) for English-language content posted on the web. Social media platforms that did not provide public access to information or posts were excluded. Social media posts from Australia, Canada, the United Kingdom, and the United States were retrieved using the Social Studio platform—a web-based aggregator tool.

Results
Of the 25,590 posts identified initially, 464 posts about COSP were considered relevant; the majority of conversations (98.3%, n=456) were posted by adults (aged >18 years). Work status was mentioned in 52 conversations. Patients’ or caregivers’ discussions across social media platforms were centered around the symptoms (61.9%, n=287) and causes (58%, n=269) of ocular pain. Patients mentioned having symptoms associated with COSP, including headache or head pressure, dry or gritty eyes, light sensitivity, etc. Patients posted that their COSP impacts day-to-day activities such as reading, driving, sleeping, and their social, mental, and functional well-being.

Conclusions
Insights from this study reported patients’ experiences, concerns, and the adverse impact on overall QoL. COSP imposes a significant burden on patients, which spans multiple aspects of daily life.
governo da infância no filme Sciuscià
Authors: Fernandes Isabella , Pinheiro Veralúcia 
Published: December 2023

O presente artigo visa investigar o processo de controle da criança e sua constituição objetiva e subjetiva por meio da análise dos discursos sobre a infância e as práticas de governo da sua conduta no filme Sciuscià de Vittorio De Sica 1946, que retrata das condições da sociedade italiana no pós Segunda Guerra Mundial. Com efeito, evidenciar as estratégias de controle e sujeição da infância pobre nesta conjuntura como forma de produzir um determinado tipo de subjetividade. Apontar os elementos que se constituem em dados de análise (sócio-histórico, personagens, imagens, linguagem cinematográfica, etc.) da investigação, reveladora das concepções de infância.Utilizou-se a metodologia de análise fílmica de Vanoye e Golliot-Lété (2002) e como fonte: estudos bibliográficos, o filme Sciuscià e a revisão fílmica da obra de Vittorio De Sica, vinculada ao movimento cultural e estético neorrealista. A negligência do papel do Estado é evidenciada e explicitada por meio da política de sujeição nos reformatórios, com suas tecnologias “pedagógicas” de governo da infância sustentadas nos discursos oficiais que concebem a infância como risco social e vítimas da sua própria condição de vítimas.
Analisis Kinerja Reksa Dana Saham Konvensional dengan Metode Jensen’s Alpha, Sortino dan Snail Trail Periode 2017-2021
Authors: Kertiani Putu Tia , Masdiantini Putu Riesty 
Published: December 2023

This study aims to analyze the performance of conventional equity mutual funds using jensen's Alpha, Sortino, and Snail Trail methods for the period 2017 to 2021 and can provide information and consideration regarding equity mutual funds. The measurement methods used in analyzing the performance of conventional stock mutual funds are Jensen's Alpha, Sortino, and Snail Trail. The sample used was 32 conventional stock mutual funds with a period of 5 years 2017-2021. The benchmark for stock mutual funds used for comparison is JCI. The data collection technique uses the purposive sampling method. Data analysis techniques in this study used the Mann Whitney U-test. The results showed that the performance of conventional equity mutual funds using Jensen's Alpha and Sortino methods had significant differences. The performance of conventional equity mutual funds using Jensen's Alpha and Sortino methods has significant differences and has superior performance compared to market performance. The results of snail trail show that the performance of conventional equity mutual funds is in quadrants 2 and 3. Equity mutual funds located in quadrant 2 have a relatively high value of return and risk and each stock mutual fund located in quadrant 3 has a relatively low return with high risk. The more often the snail trail of stock mutual funds is located in 3rd quarter, it is likely that investors will switch to other types of mutual funds.
Pengaruh Tingkat Pendapatan, Literasi Keuangan dan Suku Bunga Terhadap Minat Menabung Pada Koperasi Dana Karya SariDesa Adat Bugbug
Authors: Ni Wayan Sri Widari  , Dewi Luh Gede Kusuma 
Published: December 2023

This study aims to determine the effect of income levels, financial literacy and interest rates on interest in saving in the work of the traditional bugbug village fund cooperative. The type of research used is a causal quantitative type. This study uses primary data obtained by distributing questionnaires or questionnaires. The collection of samples by purposive sampling technique and obtained 100 samples. The analytical method used is descriptive statistical analysis, classical assumption test, multiple linear regression test, and hypothesis testing with the help of SPSS 26.0 for windows application. The results of this study indicate that (1) the level of income, financial literacy and interest rates have a positive effect on interest in saving in the work of the traditional bugbug village fund cooperative.
Keywords : Income level, Financial Literature, and Interest Rates