bluuebunny/crossref_metadata_2025_split huggingface dataset:
The minimum measurable eccentricity from gravitational waves of LISA massive black hole binaries
Authors: Garg Mudit , Tiwari Shubhanshu , Derdzinski Andrea , Baker John G , Marsat Sylvain , Mayer Lucio 
Published: November 2023

ABSTRACT
We explore the eccentricity measurement threshold of Laser Interferometer Space Antenna (LISA) for gravitational waves radiated by massive black hole binaries (MBHBs) with redshifted BH masses Mz in the range 104.5–107.5 M⊙ at redshift z = 1. The eccentricity can be an important tracer of the environment where MBHBs evolve to reach the merger phase. To consider LISA’s motion and apply the time delay interferometry, we employ the lisabeta software and produce year-long eccentric waveforms using the inspiral-only post-Newtonian model taylorf2ecc. We study the minimum measurable eccentricity (emin, defined one year before the merger) analytically by computing matches and Fisher matrices, and numerically via Bayesian inference by varying both intrinsic and extrinsic parameters. We find that emin strongly depends on Mz and weakly on mass ratio and extrinsic parameters. Match-based signal-to-noise ratio criterion suggest that LISA will be able to detect emin ∼ 10−2.5 for lighter systems (Mz ≲ 105.5 M⊙) and ∼10−1.5 for heavier MBHBs with a 90 per cent confidence. Bayesian inference with Fisher initialization and a zero noise realization pushes this limit to emin ∼ 10−2.75 for lower-mass binaries, assuming a &lt;50 per cent relative error. Bayesian inference can recover injected eccentricities of 0.1 and 10−2.75 for a 105 M⊙ system with an ∼10−2 per cent and an ∼10 per cent relative errors, respectively. Stringent Bayesian odds criterion ($\ln {\mathcal {B}}\gt 8$) provides nearly the same inference. Both analytical and numerical methodologies provide almost consistent results for our systems of interest. LISA will launch in a decade, making this study valuable and timely for unlocking the mysteries of the MBHB evolution.
The Syriac Legend of Alexander's Gate
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This book is the first monographic study entirely consecrated to the Syriac text entitled Neṣḥānā d-Aleksandrōs (also known as the Syriac Alexander Legend), a seminal text for later Christian and Muslim apocalyptic traditions. While the scholarly consensus commonly dates the Neṣḥānā to the time of the Byzantine emperor Heraclius (r. 610–641 ce), this study demonstrates that an earlier version of the text was produced during the reign of Justinian I (r. 527–565). This new historical contextualization of the text enables one to better delineate the development of politicized forms of apocalypticism during Late Antiquity, a process in which the Neṣḥānā played a decisive role. By analyzing the contents and the ideology of the text, the book explores the origins and developments of important literary motifs of medieval literature worldwide, including the characterization of Alexander as a pious prophet-king (in both Christianity and Islam alike), and the story of the gate that he erects to confine the eschatological nations of Gog and Magog. Moreover, the book sheds light on lesser-known aspects of political debates in the sixth-century Near East and offers historians a valuable insight into important aspects of Justinian’s reign, as seen by an author who was not on the emperor’s payroll.
Debates about Dating and Context of the Neṣḥānā d-Aleksandrōs
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This chapter reviews earlier scholarship on the Neṣḥānā d-Aleksandrōs, with special attention to the scholarly debate over the original date of composition of the Syriac work. The author analyzes the arguments advanced by scholars in favor of an early composition of the Neṣḥānā (i.e., prior to the seventh century) and highlights the shortcomings of some of these arguments. The author then describes the views of those scholars who have argued in favor of a seventh-century composition and who have sought to set the origins of the Syriac work during the reign of Heraclius. The chapter concludes with a review of recent expressions of skepticism concerning the seventh-century dating.
The 940 ag Prophecy
Authors: Tesei Tommaso 
Published: November 2023

Abstract
In this chapter the author demonstrates, by means of philological analysis, that the only passage in the text that clearly indicates a seventh-century dating—the 940 ag prophecy referring to events that occurred between 626 and 629 ce—is in fact an interpolation within an earlier composition dating to the end of the reign of Justinian. This interpolation—the author argues—demonstrates that several decades after its composition, the Syriac work was modified in order to connect it to new historical circumstances, namely the widespread belief in the Byzantine world that the ideal emperor described in the Neṣḥānā had returned in the figure of Heraclius.
The Conflict with Tūbarlaq
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This chapter explores the section of text about the war between Alexander and his Persian rival, Tūbarlaq. Against many previous scholars, the author of this study demonstrates that themes and topoi adopted by the Syriac author do not relate to a specific understanding of the notion of holy war in the seventh century. In fact, he shows that the Neṣḥānā conforms to literary trends observable in earlier Christian texts. Then, he demonstrates that the peace agreements between Alexander and the Persian king Tūbarlaq described in the Neṣḥānā reflect the reality of Roman-Persian peace treaties in the sixth century—not the seventh century, as claimed by many scholars. By formulating an idealized version of the peace contracts stipulated by Justinian and Khosrow Anōshirvān, the Syriac author criticizes the Byzantine policy of buying peace with gold. This chapter connects the author’s criticism of Justinian to broader dissatisfactions in the Byzantine world with the emperor’s poor achievements in the conflicts with the Persians. It also demonstrates that the author’s criticism of Justinian has a close parallel in the work of another sixth-century Syriac writer, the anonymous author of the Julian Romance. Then, it analyzes the prophecy uttered by Tūbarlaq at the end of the Neṣḥānā and argues against the view that this prophecy echoes themes of Heraclius’s war propaganda. Finally, it addresses the unsolved problem of Tūbarlaq’s identity and offers a new solution for this question.
The Syriac Alexander
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This chapter situates the figure of Alexander in the Neṣḥānā in relation to the well-known phenomenon of the imitatio Alexandri, adopted by Roman historiographers and imperial propagandists to relate Eastern, “Persian,” campaigns led by Roman generals and emperors to the glorious antecedent of Alexander’s war against the Achaemenid Empire. The chapter highlights the political connotations of the image of Alexander as a kosmokrator in the mid- sixth century. Through this peculiar characterization of Alexander, the Syriac author not only expressed his anti-Sasanian feelings, which culminate in Alexander’s prophecy about the imminent collapse of the Sasanian Empire, but also criticized Justinian for his inability to repeat Alexander’s glorious deeds against the Persians and for his poor achievements in the conflict against the Sasanian enemy. In the Neṣḥānā the figure of Alexander is thus a nemesis of the Byzantine ruler. The chapter also notes the parallel between the Neṣḥānā and the Julian Romance, drawing attention to similarities between the characterizations of Alexander and Jovian in the two works—both of which criticize Justinian.
Alexander, the Danielic Visions, and the Gate against Gog and Magog
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This chapter analyzes the peculiar and unprecedented characterization of Alexander as a pious (Christian) prophet-king and as the founder of the Roman Empire, envisaged as an eschatological agent. It argues that the figure of the Christian, apocalyptic Alexander in the Syriac work is rooted in the hermeneutics of the Danielic prophecies (Dan 2, 7, and 8) developed by Christians in both the Byzantine and Sasanian empires to situate the two empires in the framework of God’s plan for human salvation. The chapter emphasizes the parallels between the Neṣḥānā and the conceptualization of Alexander’s kingdom in Aphrahat’s (d. 345 ce) hermeneutic of Daniel. Finally, the chapter argues that a better understanding of the ideology and concepts behind the elaboration of the Syriac Alexander helps the reader to better understand the development of the story of Alexander’s eschatological gate. It demonstrates that some main features of the episode of the gate are embedded with a symbolism that relates to the Neṣḥānā author’s readings of the Danielic prophecies and to his views on the role of Alexander’s empire in sacred history.
Alexander’s Horns
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This chapter analyzes the first part of the prayer that Alexander addresses to God at the beginning of the Syriac work, with special attention to the motif of Alexander’s horns in the Neṣḥānā. This motif emerges from ancient iconographic representations of Alexander crowned with ram horns—as in the effigies of the Greco-Egyptian god Zeus-Ammon. Unlike late antique Christians, who typically displayed hostility toward this pagan symbolism, the author of the Neṣḥānā Christianizes the image of the horned Alexander by reading it through the lens of biblical texts—including the Book of Daniel. The author uses the motif of Alexander’s horns to formulate an innovative hermeneutic of the Danielic vision of the ram and the he-goat in Daniel 8. This hermeneutic results in the attribution of an apocalyptic value to the ancient horn symbolism. The chapter argues that this literary operation is related to the author’s willingness to address contemporary political circumstances, especially Byzantine-Sasanian relationships. Through a sophisticated combination of biblical and Classical traditions, the Syriac author transforms the ancient representation of the horned Alexander into an element of his anti-Sasanian polemic.
Anxiety and depression in rheumatoid arthritis patients: prevalence, risk factors and consistency between the Hospital Anxiety and Depression Scale and Zung’s Self-rating Anxiety Scale/Depression Scale
Authors: Cheng Lu , Gao Wenjia , Xu Yan , Yu Zhe , Wang Wen , Zhou Jun , Zang Yinshan 
Published: November 2023

Abstract

Objectives
The aim was to explore the prevalence and independent risk factors for anxiety and depression in RA patients and to assess the consistency between the hospital anxiety and depression scale (HADS) and Zung’s self-rating anxiety scale/depression scale (SAS/SDS).

Methods
In total, 160 RA patients and 60 healthy controls (HCs) were enrolled consecutively, and HADS and SAS/SDS were completed.

Results
The HADS-defined anxiety rate, HADS-defined depression rate, SAS-defined anxiety rate and SDS-defined depression rate were 36.9, 36.3, 29.4 and 29.4%, respectively, in RA patients, all of which were much higher in RA patients than in HCs (all P &lt; 0.001). A relatively high consistency was observed between HADS-defined anxiety and SAS-defined anxiety (κ = 0.551, P &lt; 0.001) and between HADS-defined depression and SDS-defined depression (κ = 0.563, P &lt; 0.001) in RA patients. Interestingly, screened by multivariate logistic regression analyses, single/divorced/widowed marital status, swollen joint count, disease duration, ESR, physician’s global assessment (PhGA) and DAS28 were independently correlated with HADS-defined or SAS-defined anxiety risk in RA patients; meanwhile, female biological sex, single/divorced/widowed marital status, rural location, disease duration, PhGA and DAS28 were independently associated with HADS-defined or SDS-defined depression risk in RA patients.

Conclusion
Anxiety and depression are highly prevalent in RA patients and are independently correlated with single/divorced/widowed marital status and higher disease activity. In addition, the HADS presents a high consistency with the SAS/SDS with many fewer questions, which might be more suitable for long-term assessment of RA.
Individual and organizational effects of international mobility policy: Effects of Mexico’s Scholarship Program in nanotechnology
Authors: Tirado Mayra M 
Published: November 2023

Abstract
This paper addresses policy effects of international mobility in developing countries. It proposes a multilevel approach to study research training policies, specifically focusing on international mobility schemes as capacity-building instruments, where effects need to be identified at both individual and organizational levels. The paper asserts that current categorizations of country efforts to build a solid scientific base should consider transference of effects in domestic research contexts. Using a survey and interview-based study of a mobility policy in Mexico, and nanotechnology-related disciplines and sectors, this paper’s findings suggest that mobility policies are crucial in creating high-quality individual research skills, but that their impact on building domestic research capacity may be modest. This paper contributes to the evaluation literature on national research training programs and their influence on research capacity in two ways. First, it mobilizes a multilevel analytical approach to examine the effects of policies on individuals and organizations, offering a broader conceptualization of impact. Second, by introducing these individual and organizational effects, the paper provides insights into how effects are enacted and transferred.
Cultural variation in neural responses to social but not monetary reward outcomes
Authors: Blevins Elizabeth , Ko Michael , Park BoKyung , Qu Yang , Knutson Brian , Tsai Jeanne L 
Published: November 2023

Abstract
European Americans view high-intensity, open-mouthed ‘excited’ smiles more positively than Chinese because they value excitement and other high arousal positive states more. This difference is supported by reward-related neural activity, with European Americans showing greater Nucleus Accumbens (NAcc) activity to excited (vs calm) smiles than Chinese. But do these cultural differences generalize to all rewards, and are they related to real-world social behavior? European American (N = 26) and Chinese (N = 27) participants completed social and monetary incentive delay tasks that distinguished between the anticipation and receipt (outcome) of social and monetary rewards while undergoing Functional Magnetic Resonance Imaging (FMRI). The groups did not differ in NAcc activity when anticipating social or monetary rewards. However, as predicted, European Americans showed greater NAcc activity than Chinese when viewing excited smiles during outcome (the receipt of social reward). No cultural differences emerged when participants received monetary outcomes. Individuals who showed increased NAcc activity to excited smiles during outcome had friends with more intense smiles on social media. These findings suggest that culture plays a specific role in modulating reward-related neural responses to excited smiles during outcome, which are associated with real-world relationships.
Naturally occurring autoimmune disease in (NZB × NZW) F1 mice is correlated with suppression of MZ B-cell development due to aberrant B-cell receptor (BCR) signaling, which is exacerbated by exposure to inorganic mercury
Authors: Gill Randall F , Mathieu Patricia A , Lash Lawrence H , Rosenspire Allen J 
Published: November 2023

Abstract
Autoimmune diseases are multifactorial and include environmental as well as genetic drivers. Although much progress has been made in understanding the nature of genetic underpinnings of autoimmune disease, by comparison much less is understood regarding how environmental factors interact with genetics in the development of autoimmunity and autoimmune disease. In this report, we utilize the (New Zealand black × New Zealand white [NZB × NZW]) F1 mouse model of systemic lupus erythematosus (SLE). Mercury is a xenobiotic that is environmentally ubiquitous and is epidemiologically linked with the development of autoimmunity. Among other attributes of human SLE, (NZB × NZW) F1 mice spontaneously develop autoimmune-mediated kidney disease. It has been previously shown that if (NZB × NZW) F1 mice are exposed to inorganic mercury (Hg2+), the development of autoimmunity, including autoimmune kidney pathology, is accelerated. We now show that in these mice, the development of kidney disease is correlated with a decreased percentage of marginal zone (MZ) B-cells in the spleen. In Hg2+-intoxicated mice, kidney disease is significantly augmented, and matched by a greater decrease in MZ B-cell splenic percentages than found in control mice. In Hg2+- intoxicated mice, the decrease in MZ B-cells appears to be linked to aberrant B-cell receptor signal strength in transitory 2 (T2) B-cells, developmental precursors of MZ B-cells.
Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential
Authors: Chappell Todd C. , Maiello Kathleen G. , Tierney Allison J. , Yanagi Karin , Lee Jessica A. , Lee Kyongbum , Mace Charles R. , Bennett Clay S. , Nair Nikhil U. 
Published: November 2023

AbstractMicrobial derived natural products remain a major source of structurally diverse bioactive compounds and chemical scaffolds that have potential as new therapeutics to target drug resistant pathogens and cancers. In particular, genome mining has revealed the vast number of cryptic or low yield biosynthetic gene clusters in the genusStreptomyces. Here, we describe our efforts to improve yields of landomycins – angucycline family polyketides under investigation as cancer therapeutics – by a genetically modifiedStreptomyces cyanogenus136. After simplifying the extraction process fromS. cyanogenuscultures, we identified a wavelength at which the major landomycin products absorb in culture extracts, which we used to systematically explore culture medium compositions to improve total landomycin titers. Through correlational analysis, we simplified the culture optimization process by identifying an alternative wavelength at which culture supernatants absorb yet is representative of total landomycin titers. Using the subsequently improved sample throughput, we explored landomycin production during the culturing process to further increase landomycin yield and reduce culture time. Testing the antimicrobial activity of the isolated landomycins, we report broad inhibition of Gram-positive bacteria, inhibition of fungi by landomycinone, and broad landomycin resistance by Gram-negative bacteria that is likely mediated by exclusion of landomycins by the bacterial membrane. Finally, the anticancer activity of the isolated landomycins against A549 lung carcinoma cells agrees with previous reports on other cell lines that glycan chain length correlates with activity. Given the prevalence of natural products produced byStreptomyces, as well as the light-absorbing moieties common to bioactive natural products and their metabolic precursors, our method is relevant to improving the yields of other natural products of interest.
Rediscovering theRete Ovarii: a secreting auxiliary structure to the ovary
Authors: Anbarci Dilara N. , McKey Jennifer , Levic Daniel S. , Bagnat Michel , Capel Blanche 
Published: November 2023

AbstractTherete ovarii(RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textbooks, and is often dismissed as a functionless vestige in the adult ovary. Using PAX8 immunostaining and confocal microscopy, we characterized the fetal development of the RO in the context of the ovary. The RO consists of three distinct regions that persist in adult life, the intraovarian rete (IOR), the extraovarian rete (EOR), and the connecting rete (CR). While the cells of the IOR appear to form solid cords within the ovary, the EOR rapidly develops into a convoluted tubular epithelium ending in a distal dilated tip. Cells of the EOR are ciliated and exhibit cellular trafficking capabilities. The CR, connecting the EOR to the IOR, gradually acquires tubular epithelial characteristics by birth. Using microinjections into the distal dilated tip of the EOR, we found that luminal contents flow towards the ovary. Mass spectrometry revealed that the EOR lumen contains secreted proteins potentially important for ovarian function. We show that the cells of the EOR are closely associated with vasculature and macrophages, and are contacted by neuronal projections, consistent with a role as a sensory appendage of the ovary. The direct proximity of the RO to the ovary and its integration with the extraovarian landscape suggest that it plays an important role in ovary development and homeostasis.
A seven-sex species recognizes self and non-self mating-type via a novel protein complex
Authors: Yan Guanxiong , Ma Yang , Wang Yanfang , Zhang Jing , Cheng Haoming , Tan Fanjie , Wang Su , Zhang Delin , Xiong Jie , Yin Ping , Miao Wei 
Published: November 2023

AbstractAlthough most species have two sexes, multisexual (or multi-mating type) species are also widespread. However, it is unclear how mating-type recognition is achieved at the molecular level in multisexual species. The unicellular ciliateTetrahymena thermophilahas seven mating types, which are determined by the MTA and MTB proteins. In this study, we found that both proteins are essential for cells to send or receive complete mating-type information, and transmission of the mating-type signal requires both proteins to be expressed in the same cell. We found that MTA and MTB form a mating-type recognition complex that localizes to the plasma membrane, but not to the cilia. Stimulation experiments showed that the mating-type-specific regions of MTA and MTB mediate both self- and non-self-recognition, indicating thatT. thermophilauses a dual approach to achieve mating-type recognition. Our results suggest that MTA and MTB form an elaborate multifunctional protein complex that can identify cells of both self and non-self mating types in order to inhibit or activate mating, respectively.Impact statementA giant multifunctional protein complex mediates mating-type recognition through a non-ligand-receptor mechanism in a multisexual species.
BioWiC: An Evaluation Benchmark for Biomedical Concept Representation
Authors: Rouhizadeh Hossein , Nikishina Irina , Yazdani Anthony , Bornet Alban , Zhang Boya , Ehrsam Julien , Gaudet-Blavignac Christophe , Naderi Nona , Teodoro Douglas 
Published: November 2023

AbstractDue to the complexity of the biomedical domain, the ability to capture semantically meaningful representations of terms in context is a long-standing challenge. Despite important progress in the past years, no evaluation benchmark has been developed to evaluate how well language models represent biomedical concepts according to their corresponding context. Inspired by the Word-in-Context (WiC) benchmark, in which word sense disambiguation is reformulated as a binary classification task, we propose a novel dataset, BioWiC, to evaluate the ability of language models to encode biomedical terms in context. We evaluate BioWiC both intrinsically and extrinsically and show that it could be used as a reliable benchmark for evaluating context-dependent embeddings in biomedical corpora. In addition, we conduct several experiments using a variety of discriminative and generative large language models to establish robust baselines that can serve as a foundation for future research.