bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Isolation and Its Impact on Chronic Pain
Authors: Brown Darryl , Maryansky Aleksey , Nguyen Trong Phu , Breidenbach Kathryn A. , Kim Soo Yeon , Okorozo Aham , Lin Hung-Mo , Kim Jung 
Published: January 2024

Abstract
In an effort to mitigate the spread of COVID-19, New York City enforced a "shelter-in-place" order from March 20 to June 13, 2020. This study aims to explore the impact of self-isolation resulting from this order on individuals with chronic pain. The primary outcomes, assessed through the Brief Pain Inventory questionnaire, included self-rated pain scores and functional scores. A total of 65 participants completed the questionnaire during the quarantine period and again during the reopening phase from July 1 to August 31, 2020. While most self-rated pain scores showed no significant difference between the two periods, 24-Hour Worst Pain demonstrated improvement in the post-quarantine period (median 0; IQR [-1, 0]; p = 0.034). Notably, various functional scores, such as General Activity, Mood, Normal Work, Relations, Sleep, and Enjoyment of Life, exhibited substantial improvement post-quarantine, resulting in an overall functional score difference of -1.30 on average (p < 0.001). Despite stable self-rated pain scores, the study reveals a significant increase in disability during quarantine, possibly attributed to factors like fear, social isolation, and resource scarcity. The findings underscore the importance of holistic pain management considering psychosocial factors.
A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever
Authors: Hawman David , Leventhal Shanna , Meade-White Kimberly , Khandhar Amit , Murray Justin , Lovaglio Jamie , Shaia Carl , Saturday Greg , Erasmus Jesse , Feldmann Heinz 
Published: January 2024

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne febrile illness with wide geographic distribution. In recent years the geographic range of Crimean-Congo hemorrhagic fever virus (CCHFV) and its tick vector have increased, placing an increasing number of people at risk of CCHFV infection. Currently there are no widely available vaccines and although the World Health Organization recommends ribavirin for treatment, its efficacy is unclear. Here we evaluate a promising replicating RNA vaccine in a rhesus macaque (Macaca mulatta) model of CCHF. This model provides an alternative to the established cynomolgus macaque model and recapitulates mild-to-moderate human disease. Rhesus macaques infected with CCHFV consistently exhibit viremia, detectable viral RNA in a multitude of tissues and moderate pathology in the liver and spleen. We used this model to evaluate the immunogenicity and protective efficacy of a replicating RNA vaccine. Rhesus macaques vaccinated with RNAs expressing the CCHFV nucleoprotein and glycoprotein precursor developed robust non-neutralizing humoral immunity against the CCHFV nucleoprotein and had significant protection against CCHFV challenge. Together our data report a model of CCHF using rhesus macaques and demonstrate that our replicating RNA vaccine is immunogenic and protective in non-human primates after a prime-boost immunization.
Enhanced mGluR5 Availability Marks the Antidepressant Efficacy in Major Depressive Disorder
Authors: Zhang Yan , Liu Bangshan , Deng Aoqian , Dong Chuning , Chen Wentao , Zhang Qianqian , Zhou Lianbo , He Feng , Xiang Xin , Ou Wenwen , Ma Mohan , Liu Jin , Wang Xiaoping , Ju Yumeng , Wang Yunhua , Huang Henry , Ma Xiaowei 
Published: January 2024

Abstract

The limited efficacy of antidepressants for Major Depressive Disorder (MDD) underscores the need for novel targets. This study explores the role of metabotropic glutamate receptor 5 (mGluR5) in MDD, examining mGluR5 availability changes pre and post-treatment and their link to clinical outcomes. We studied 25 MDD patients and 21 healthy controls, with 13 undergoing eight-week vortioxetine treatment. mGluR5 availability was measured at baseline and follow-up using [18F]FPEB-PET scans, categorizing patients based on response. Results showed a global decrease in mGluR5 availability in MDD patients versus controls at baseline. Post-treatment, remitters exhibited a significant increase in mGluR5 availability in the dorsolateral and ventromedial prefrontal cortex (Cohen’s d = 2.33 and 4.27). These findings underscore mGluR5's key role in MDD pathophysiology and treatment. The post-treatment increase in mGluR5 in key brain areas among remitters suggests its potential as a novel therapeutic target for MDD.
Impact of hypertension on cardiovascular outcomes and all-cause mortality in older patients with obstructive sleep apnea
Authors: Jianhua Li , GAO Ying-Hui , Xue Xin , GAO Yan , GUO Jing-Jing , ZHAO Li-Bo , ZHAO Zhe , WANG Huan-Huan , SU Xiao-Feng , SHI Min , ZOU Xiao , XU Wei-Hao , WANG Ya-Bin , QIAN Xiao-Shun , CHEN Kai-Bing , LIN Jun-Ling , LIU Lin 
Published: January 2024

Abstract

Background and Aim: Although hypertension and obstructive sleep apnea (OSA) frequently coexist, few prospective cohort studies have examined the relationship between hypertension and the risk of cardiovascular events and mortality in older patients with OSA. This study sought to determine how hypertension affected cardiovascular incidents and death in older patients with OSA.
Methods: This multicenter, prospective cohort study comprised a sample of 1,113 older individuals (≥60 years) with OSA between January 2015 and October 2017. The following data were gathered: baseline demographics, sleep measures, clinical traits, and follow-up results. The mean follow-up period was 42 months (range: 1–72 months). Major adverse cardiovascular events (MACE) were the primary outcome. All-cause mortality, MACE subcomponents, and a composite of all events served as the secondary end points.
Results: A total of 706 (63.4%) OSA patients had hypertension. The risk of MACE (HR=2.13, 95%CI: 1.28–3.57, p<0.05); hospitalization for unstable angina (HR=2.03, 95%CI: 1.03–4.00, p<0.05); and a composite of all events (HR=1.75, 95%CI: 1.12–2.73, p<0.05) was higher in older OSA patients who had hypertension, according to a multivariable Cox regression analysis. In a subgroup analysis, male patients, those under 75 years, and those with moderate-to-severe OSA had increased the adjusted HRs for MACE by hypertension. However, there were no discernible changes in the incidence of cardiovascular death, all-cause mortality, myocardial infarction, or heart failure between patients with and without hypertension (p>0.05).
Conclusions: In older OSA patients, hypertension is independently linked to a higher risk of MACE, hospitalization for unstable angina, and a composite of all events. Male sex, age<75 years, and moderate-to-severe OSA, coupled with hypertension, presented a particularly high MACE risk.
Impact of cobalt and zinc stress on Rehmannia glutinosa growth, bioactive compound production, antioxidant activity, and molecular dynamics simulation
Authors: Ghimire Bimal Kumar , Alharbi Naiyf S. , Kadaikunnan Shine , Sriniva Prabhu , Thiruvengadam Muthu 
Published: January 2024

Abstract
The effects of cobalt (Co) and zinc (Zn) on the growth of Rehmannia glutinosa, as well as its antioxidant activity, total phenolic and flavonoid contents (TPC and TFC), targeted polyphenolic compounds, and molecular dynamics simulations were studied. The results revealed that exposure to 0.01 to 0.1 ppm Zn in the growth medium increased plant height, average number of leaves, and root length. Higher concentrations of Zn had deleterious effects, and lower concentrations of Co (0.01 and 0.1 ppm) significantly inhibited growth, as indicated by the retardation and reduction in root length, plant height, and leaf numbers. Higher concentrations of Co (1 ppm) cause early defoliation, necrosis, and plant death. The highest concentration of Zn (1 ppm) caused a significant decrease in Chl a concentration compared to the other concentrations and the control plants. Lower concentrations of Zn and Co (0.01 ppm) showed elevated radical-scavenging activity compared with that of the control plants. Maximum TPC and TFC were achieved at 0.01 ppm of Zn, while a higher concentration of TPC and TFC was obtained with 0.1 ppm of Co. Furthermore, catalase and ascorbate peroxidase activity were significantly affected by Zn and Co. The targeted phenolic compounds were analyzed by LC-MS-MS in the Zn- and Co-treated and control plants. Finally, to evaluate the stability of phytochemicals with high binding affinities and docking scores, a 100-ns molecular dynamic simulation was performed. These findings suggest that exposure to high concentrations of Zn- and Co-contaminated soils may affect the growth and metabolism of R. glutinosa.
Assessing the Efficacy of an Educational Video on Stroke Knowledge in Lebanon: A Study with an Interventional Approach
Authors: Safwan Jihan , Iskandar Katia , Haddad Chadia , Sacre Hala , Salameh Pascale , Youssef Serena , Akl Tatiana , Sfeir Yasmina , Hosseini Hassan , Sakr Fouad , Cherfane Michelle 
Published: January 2024

Abstract

Objective
This study aimed to assess the public’s knowledge of stroke before and after viewing an educational video about stroke risk factors, preventive measures, and alarming signs.
Methods
A population-based interventional study was conducted in Lebanon using a 3-minute video-based education about stroke. A pre- and post-structured questionnaire compared the level of knowledge about stroke.
Results
The study included 685 participants. Knowledge of stroke, risk factors, warning signs, treatment, and preventive measures significantly increased post-educational video sessions. A higher baseline knowledge score was associated with a family history of stroke (Beta = 1.76) and being a healthcare professional (Beta = 3.35). Participants between 25 and 34 years (Beta=-1.39) and those with a high risk of stroke (Beta=-1.03) were significantly associated with a lower knowledge score.
Conclusion
This study demonstrated the effectiveness of a video-based educational tool to raise awareness about stroke. Short, targeted audio-visual resources using lay language can convey health education messages and influence behavioral changes. The community can benefit from a large-scale educational campaign that targets different socio-economic statuses to enhance knowledge of stroke and save lives.
A move toward green agriculture: Discovery of novel environmental-friendly insecticidal ‘’ulvan’’ from the renewable bioresource Ulva lactuca; effect of the extraction processes on the chemical-physical, and insecticidal properties
Authors: Guidara Mariem 
Published: January 2024

Abstract

The research of effective insecticidal agents is important challenging to limit the insecticide resistance of many larvae insect populations. This study aimed not only, to discover the insecticidal efficiency of the sulphated polysaccharide ‘ulvan’ from the green seaweed Ulva lactuca, as a novel environmental-friendly insecticidal agent; but also, to investigate an alternative strategy for insecticide productions and to improve the effective control of Spodoptera littoralis larvae. This aim reached by the investigation of the enzymatic chemical extraction and acid extractions effects on physical properties and insecticidal activities of ulvan extract; for further, feasible and optimal application of ulvans, as insecticidal agent. The study demonstrated that ulvans were characterized by anionic stable structure and molecular weight distribution; varied between 1.77 and 7.21 (×102 kDa), as well as, special particle size, which were affected by extraction processes. Ulvan will be a precious candidate due to their bioactivity and environmental safety. The extraction procedure effects were observed in chemical composition, molecular weight, particle size, surface charge and insecticidal activities of ulvans. At high concentrations, the enzymatic-chemical (EE) and acidic (CA1) extraction processes can successfully produce ulvans with the greatest insecticidal activities against S. littoralis larvae. The mortality rate of larvaes after treatments with concentration at 100 (mg/ml), achieved 75% of larvae’s mortality. LC 30, LC50 and LC 90 evidenced the expected outcome of the insecticidal ability of ulvans. The insecticidal efficiency of ulvans with a dose-dependent manner promote their use as novel eco- friendly bio-insecticidal agent suitable for the agriculture systems needs and technology trends. This strategy of (EE) and (CA1) extraction processes can considerably improve the economic and environmental benefits.
Variation of Tap Water Properties Using Cold Plasma
Authors: Mohammadi Mohammad Ali , Naghibzadeh S. T. , Baharlounezhad F. , Zakerhamidi M.S. 
Published: January 2024

Abstract

It is crucial to analyze the aqueous system's electrical conductivity, pH, and temperature to evaluate its quality for the intended use. This study examined the impact of exerting several cold plasmas (argon, nitrogen, air, and oxygen) on the alteration of tap water properties used for a variety of applications under atmospheric pressure. The findings indicated that electrical conductivity and temperature were ascending-descending for non-homogenized water and ascending for homogenized water after plasma exerting. The effects of argon, nitrogen, air, and oxygen plasmas on homogenized water resulted in acidification water. According to the agreement of the results with the previous reports, oxygen gas with the most decrease in pH was chosen to change the acidic result. Oxygen plasma exerting caused basic properties in water after filtering water via argon gas. It was shown that is possible to obtain different results through a change in plasma exerting process from the same reactor. So, this attribute of the designed reactor made it capable of being used in many applications.
Assessing the waterbodies through water quality index and zooplankton diversity for environmental sustainability of Bankura, West Bengal, India
Authors: Mahanty Subhajit , Saha Dipankar , Karmakar Ajay , Mandal Saptarshi , Mandal Rakesh Kumar , Bhutia Dechen Doma , Majumder Surajit 
Published: January 2024

Abstract
Waterbodies play a fundamental role within the society, impacting various aspects of our lives. In an aquatic ecosystem, plankton diversity regulates the productivity of these waterbodies. The distribution patterns of plankton are closely associated with the distinct physicochemical attributes exhibited by each waterbody. This research aims to investigate the intricate relationships between physicochemical parameters and plankton distribution across diverse waterbodies encircling the Bankura district. The focal point of this study is to discern the correlations between physicochemical parameters and plankton distribution within the specified waterbodies. The comprehensive approach here involves the collection of both water and plankton samples, followed by a meticulous measurement of physicochemical parameters and plankton diversity, adhering to well-established methodologies. The sampling was done between August 2022 to May 2023. The study sites have been classified into two categories. Normal waterbodies and bloom forming waterbodies. Statistical methodologies are harnessed to find correlations and interdependencies. One way ANOVA of all physicochemical parameters and zooplankton showed highly significant difference (p < 0.05) between two categories of waterbodies. The results unveiled significant insights, particularly the notable Pearson’s correlation (p < 0.05) between different physicochemical parameters and zooplankton group. Occasionally, waterbodies became enriched with nutrients (PO4 − 3-P, NO2−-N), which subsequently trigger excessive plant growth, a phenomenon recognized as eutrophication, culminating in the formation of toxic red algal blooms. One potential causative agent behind these red blooms is Euglena sp. Several diversity indices are used to evaluate the abundance and species richness in the waterbodies. Water quality index of different study sites has been developed to find the status of the waterbodies. The current investigation strongly underscores the significant correlations that exist between the plankton diversity of the studied waterbodies and their underlying physicochemical attributes. This insight not only enhances our comprehension of the intricate dynamics within these ecosystems but also emphasizes the imperative role of physicochemical parameters influencing plankton distributions.
Effect of ensiled mixture of apple pomace and wheat straw based complete feed on growth performance of calves
Authors: Chauhan Sunidhi , Wadhwa Daisy , Sharma A. , Katoch S. , Upadhyay S. 
Published: January 2024

Abstract
The study was conducted with the aim to find out the effect of ensiled apple pomace based complete feed on growth response of calves. Ten male cross-bred calves were used for determination of dry matter intake (DMI), gain in weight (GIW) and feed efficiency ratio (FER) of ensiled apple pomace based complete feed. Ensiled mixture of apple pomace (AP) and wheat straw (WS) i.e. (EMAPWS) was mixed with concentrate feed and fed to Group 1 calves. The Group 2 calves were fed with ensiled AP in which fresh WS i.e. (EMAPFWS) and concentrate was mixed just before feeding. Growth parameters such as (GIW (Kg/week/calf and Kg/day/calf), DMI (% body weight/calf) and feed efficiency ratio were worked out up to 8 weeks. The overall average DMI in Group 1 and Group 2, respectively, was 2.791 and 2.507 per cent of body weight. The overall average GIW was 2.019 and 1.825 kg, respectively, in Group 1 and Group 2. The overall average daily gain in weight was 288 and 260 g/calf/day in Group 1 and Group 2, respectively. There was non-significant variation in FER between both the groups. The overall feed efficiency ratio was 0.1475 and 0.1876 in Group 1 and Group 2, respectively. The overall feed efficiency ratio of Group 2 was 27.19 percent higher than Group 1. It meant that higher DMI, GIW and FER could be achieved by ensiling WS and AP together and was more palatable than adding fresh WS in ensiled AP.
Multi-objective optimization of decoration engineering construction organization based on genetic algorithm
Authors: Yang Shujuan , Yu Dehu , Liu Yu , Sun Baodi 
Published: January 2024

Abstract
Abstract：The comprehensive optimization of decoration construction organization is of great significance to rational construction and reduces the construction period and construction costs. Flow construction is an important approach for the optimization of construction decoration engineering; however, it has not been used in the multi-objective optimization of the construction organization in decoration engineering. Moreover, current researches on the multi-objective optimization of the construction organization in decoration engineering does not consider the dynamic situations in practice. Consequently, there exists a difference between optimization research and practice. Therefore, this paper presented a multi-population genetic algorithm (MPGA) for optimizing the construction sequence of orders placed by customers and realizing multi-objective optimization of the construction period, transportation costs, and delay time of decoration engineering. Furthermore, three dynamic scenarios were proposed, where in a new customer placed an order, a process delay occurred, and an emergency order was received; a dynamic multi-objective optimization algorithm was also designed to solve the target problem. The results of the case study revealed that the Pareto solution obtained by the MPGA could shorten the construction period, reduce transportation costs, and reduce labor delay times, as compared with those before optimization. Moreover, the MPGA could effectively solve the multi-objective optimization problem of a decoration engineering construction organization, serving as a reference for the development of algorithms to solve the construction management problem; this, in turn, can promote the reform and development of the construction industry in the intelligent era.
The ocean flows downhill near the seafloor and recirculates uphill above
Authors: Schubert René , Gula Jonathan , Capó Esther , Damien Pierre , Molemaker Jeroen , Vic Clément , McWilliams J C 
Published: January 2024

Abstract

The oceans circulation redistributes heat, salt, biota, dissolved gases, microplastics, and sediments on Earth. The interior ocean, 100 - 1000 m above the sloping seafloor, moves on average mainly with the deeper seafloor to its left in the Northern Hemisphere and to its right in the Southern Hemisphere. It has not been addressed how bottom friction and the steepness of the seafloor affect this widespread interior flow and what the consequences are for the vertical circulation. Here we show, using current meter measurements and numerical simulations, that the interior flow is deflected by bottom friction into a widespread near-bottom downhill flow, which is stronger the steeper the seafloor. Typical local changes in seafloor steepness lead to a shallow divergence and a deep convergence of this downhill flow that are connected by an overlaying uphill re-circulation to closed overturning cells that reach far up into the water column. As oceanic overturning is climate-relevant, our study highlights the need to better understand the associated dynamics, to identify its climate and Earth system impacts, and to implement these impacts into climate and Earth system simulations. Furthermore, the effects of widespread near-bottom downwelling on sediments, microplastics, and biota need to be investigated in the future.
Sentiment analysis of Twitter posts related to a COVID-19 Test and Trace Program in NYC
Authors: Tsai Krystle A , Chau Michelle M , Wang Juncheng , Thorpe Lorna E. , Massar Rachel E. , Conderino Sarah , Berry Carolyn A. , Islam Nadia S. , Bershteyn Anna , Bragg Marie A 
Published: January 2024

Abstract

As part of a program evaluation of the New York City Test & Trace program (T2)–one of the largest such programs in the US–we conducted a study to assess how implementing organizations (NYC Health & Hospitals, other government agencies, CBOs) communicated information about the T2 program on Twitter. Study aims were: 1) quantify reach and engagement of T2 Twitter posts by NYC organizations and celebrities; 2) examine social media users’ perceptions of T2 through sentiment analysis of social media users’ T2-related posts; and 3) examine the engagement associated with Chelsea Clinton’s tweet about T2. In our sample of 1,987 T2-related posts, celebrities and CBOs generated more user engagement (0.26% and 0.07%, respectively) compared to government agencies (e.g., Mayor’s Office, 0.0019%). Sentiment analysis revealed that positive tweets (46.5%) had higher user engagement than negative tweets (number of likes: R2 = .095, p < .01), reinforcing the value of engaging with celebrities and CBOs.