bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Color Pure Organic Room Temperature Phosphorescent Materials with Long Lifetime and High Efficiency
Authors: Guan Zhihao , Tang Zhaorun , Deng Junjie , Zheng Yuewei , Li Houbin , Liu Xinghai 
Published: November 2023

AbstractOrganic room temperature phosphorescent (ORTP) materials have garnered significant interest in the fields of anti‐counterfeiting, optical display, and bio‐imaging owing to their distinctive optical properties. However, a major drawback of most existing ORTP materials is their short phosphorescence lifetime and low quantum yields (QYs), which greatly limit their applicability across multiple fields. In this paper, a covalently assisted host‐guest doping strategy that involves embedding three aminobenzoic acids with different carboxylate substitution positions into a cyanuric acid (CA) matrix through covalent bonding using microwave heating is proposed. All three prepared ORTP materials exhibit long phosphorescence lifetime exceeding 600 ms and high phosphorescence quantum yields (PhQYs) surpassing 20%. Among them, the composite of 2‐aminoterephthalic acid (2‐A) anuric acid stands out with its unique blue phosphorescence, boasting an exceptional absolute photoluminescence quantum yield (PLQY) of 98.95% and remarkable phosphorescence quantum yield (PhQY) of 76.42%, along with a long lifetime of 800 ms. Importantly, these high‐performance ORTP materials have been successfully utilized in anti‐counterfeiting and display applications.
Controllable Adaptive Molybdate‐Oligosaccharide Nanoparticles Regulate M2 Macrophage Mitochondrial Function and Promote Angiogenesis via PI3K/HIF‐1α/VEGF Pathway to Accelerate Diabetic Wound Healing
Authors: Huang Xiuhong , Zheng Liqin , Zhou Yueshan , Hu Shaonan , Ning Wancheng , Li Simin , Lin Ziling , Huang Shaohong 
Published: November 2023

AbstractThe complex wound environment of diabetic wounds leads to poor treatment efficacy, and the inflammatory disorders and vascular injury are the primary causes of death in such patients. Herein, a sprayable, controllable adaptive, pH‐responsive nanosystem of molybdate and oligosaccharide (CMO) is specially developed as an immunomodulatory and angiogenesis‐promotion material for diabetic wound healing. CMO exhibited pH‐responsive release of Mo2+ and oligosaccharide (COS), specifically in response to the alkalescent environment observed in diabetic wounds. CMO provide an anti‐inflammatory environment by promoting M2 polarization through significantly stimulating macrophage mitochondrial function. Specifically, CMO with a certain concentration reduce reactive oxygen species (ROS) and tumor necrosis factor α (TNF‐α) expression, and upregulated mitochondrial membrane potential (MMP), superoxide dismutase (SOD), and interleukin 10 (IL‐10) expression in macrophages. Moreover, CMO facilitate angiogenesis via upregulating the PI3K/HIF‐1α/VEGF pathway—a critical process for the formation of new blood vessels that supply nutrients and oxygen to the healing tissue. Remarkably, CMO promote cell viability and migration of endothelial cells, and enhance the expression of angiogenic genes. In vitro and in vivo studies suggest this simple but powerful nanosystem targeting mitochondrial function has the potential to become an effective treatment for diabetic wound healing.
Functionality of 1‐Butyl‐2,3‐Dimethylimidazolium Bromide (BMI‐Br) as a Solid Plasticizer in PEO‐Based Polymer Electrolyte for Highly Reliable Lithium Metal Batteries
Authors: Kim Eunhui , Jamal Hasan , Jeon Injun , Khan Firoz , Chun Sang‐Eun , Kim Jae Hyun 
Published: November 2023

AbstractTo address the challenges associated with solid polymer electrolytes, flame‐retardant organic ionic plastic crystals (OIPCs) have been utilized as a solid plasticizer in composite polymer electrolytes (CPEs). In this study, 1‐butyl‐2,3‐dimethylimidazolium bromide (BMI‐Br) is used as an OIPC material. BMI‐Br and LiTFSI are initially mixed in an acetonitrile (ACN) organic solvent for a certain time. Anion exchange takes place in this mixing, replacing the Br− in BMI‐Br with TFSI−. As a result, BMI‐TFSI and Li‐Br are formed. Here, BMI‐TFSI acts as an ionic liquid, while Li‐Br serves as a salt. The 10% BMI‐Br content (BMI‐Br‐10 CPE) exhibits significant ionic conductivity (σ = 2.34 × 10−3 S cm−1 at 30 °C), wide window (up to 4.57 V), and flame retardancy. Furthermore, the BMI‐Br‐10 CPE demonstrates galvanostatic lithium plating stripping cycling stability at 100 and 300 µA cm−2 for 800 and 500 h against Li‐metal, respectively, without a significant overpotential shooting. Furthermore, at 60 °C, the BMI‐Br‐10 CPE in [LiFePO4/BMI‐Br‐10/Li] batteries demonstrates an initial capacity of 146.9 mAh g−1, capacity retention of 99.7% and high coulombic efficiency (99.5%) after 300 cycles at 1C.
Consumers' intention to adopt plant‐based meat
Authors: Chen Nai‐Hua , Tsai Meng‐Hua 
Published: November 2023

AbstractThe consumption of plant‐based meat is increasing, reflecting consumers' concerns about health, animal welfare, the environment, and sustainability. However, plant‐based meat consumption remains low owing to the barriers to shifting consumers to this nonmeat diet. We evaluate consumers' intentions to consume plant‐based meat from the perspectives of exploratory behavior and the regulatory focus theory. We collect 642 valid responses and use structural equation modeling to explore the relationship between exploratory behavior, regulatory focus values, and plant‐based meat purchase intention. exploratory behaviors encompass risk‐taking, variety‐seeking, and curiosity, while regulatory‐focus values comprise promotion‐ and prevention‐focus values. The results show that exploratory behaviors affect plant‐based meat purchase intention. Promotion‐focus value has a greater impact on purchase intention than prevention‐focus value. Promotion‐focus value mediates the relationship between exploratory behaviors and purchase intention, whereas prevention‐focus value mediates the relationship between risk‐taking and purchase intention. Drawing on consumers' consumption values, we reveal distinct managerial implications, such as providing important information and adopting online selling to attract buyers [EconLit Citations: Q01, Q13, Q55, Q56].
Association of BDNF risk variant and dorsolateral cortical thickness with long‐term treatment response to valproate in type I bipolar disorder: An exploratory study
Authors: Rodríguez‐Ramírez Alejandra Monserrat , Cedillo‐Ríos Valente , Sanabrais‐Jiménez Marco Antonio , Becerra‐Palars Claudia , Hernández‐Muñoz Sandra , Ortega‐Ortíz Hiram , Camarena‐Medellin Beatriz 
Published: November 2023

AbstractValproate is among the most prescribed drugs for bipolar disorder; however, 87% of patients do not report full long‐term treatment response (LTTR) to this medication. One of valproate's suggested mechanisms of action involves the brain‐derived neurotrophic factor (BDNF), expressed in the brain areas regulating emotions, such as the prefrontal cortex. Nonetheless, data about the role of BDNF in LTTR and its implications in the structure of the dorsolateral prefrontal cortex (dlPFC) is scarce. We explore the association of BDNF variants and dorsolateral cortical thickness (CT) with LTTR to valproate in bipolar disorder type I (BDI). Twenty‐eight BDI patients were genotyped for BDNF polymorphisms rs1519480, rs6265, and rs7124442, and T1‐weighted 3D brain scans were acquired. LTTR to valproate was evaluated with Alda's scale. A logistic regression analysis was conducted to evaluate LTTR according to BDNF genotypes and CT. We evaluated CT differences by genotypes with analysis of covariance. LTTR was associated with BDNF rs1519480 and right dlPFC thickness. Insufficient responders with the CC genotype had thicker right dlPFC than TC and TT genotypes. Full responders reported thicker right dlPFC in TC and TT genotypes. In conclusion, different patterns of CT related to BDNF genotypes were identified, suggesting a potential biomarker of LTTR to valproate in our population.
Adapting Synthetic Models of Heme/Cu Sites to Energy‐Efficient Electrocatalytic Oxygen Reduction Reaction
Authors: Meng Jia , Qin Haonan , Lei Haitao , Li Xialiang , Fan Juan , Zhang Wei , Apfel Ulf‐Peter , Cao Rui 
Published: November 2023

AbstractIn nature, cytochrome c oxidases catalyze the 4e− oxygen reduction reaction (ORR) at the heme/Cu site, in which CuI is used to assist O2 activation. Because of the thermodynamic barrier to generate CuI, synthetic Fe‐porphyrin/Cu complexes usually show moderate electrocatalytic ORR activity. We herein report on a Co‐corrole/Co complex 1‐Co for energy‐efficient electrocatalytic ORR. By hanging a CoII ion over Co corrole, 1‐Co realizes electrocatalytic 4e− ORR with a half‐wave potential of 0.89 V versus RHE, which is outstanding among corrole‐based electrocatalysts. Notably, 1‐Co outperforms Co corrole hanged with CuII or ZnII. We revealed that the hanging CoII ion can provide an electron to improve O2 binding thermodynamically and dynamically, a function represented by the biological CuI ion of the heme/Cu site. This work is significant to present a remarkable ORR electrocatalyst and to show the vital role of a second‐sphere redox‐active metal ion in promoting O2 binding and activation.
Palladium‐Catalyzed Enantioselective C−H Olefination to Access Planar‐Chiral Cyclophanes by Dynamic Kinetic Resolution
Authors: Dong Ziyang , Li Jia , Yao Ting , Zhao Changgui 
Published: November 2023

AbstractPlanar‐chiral cyclophanes have received increasing attention for drug discovery and catalyst design. However, the catalytically asymmetric synthesis of planar‐chiral cyclophanes has been a longstanding challenge. We describe the first Pd(II)‐catalyzed enantioselective C−H olefination of prochiral cyclophanes. The low rotational barrier of less hindered benzene ring in the substrates allows the reaction to proceed through a dynamic kinetic resolution. This approach exhibits broad substrate scope, providing the planar‐chiral cyclophanes in high yields (up to 99 %) with excellent enantioselectivities (up to >99 % ee). The ansa chain length scope studies reveal that the chirality of the cyclophanes arises from the bond rotation constraint of the benzene ring around the macrocycle plane, rather than the C−N axis. The C−H activation approach is also applicable to the late‐stage modification of bioactive molecules and pharmaceuticals.
Enantioselective Synthesis of Bicyclo[3.2.1]octadienes via Palladium‐Catalyzed Intramolecular Alkene‐Alkyne Coupling Reaction
Authors: Li Qiuyu , Li Jiajia , Zhang Jie , Wu Shu , Zhang Yu , Lin Aijun , Yao Hequan 
Published: November 2023

AbstractBicyclo[3.2.1]octadiene compounds and derivatives exist in a number of natural products and bioactive compounds. Nevertheless, catalytic enantioselective protocols for the synthesis of these skeletons have not been disclosed. Herein we reported a palladium‐catalyzed asymmetric intramolecular alkene‐alkyne coupling of alkyne‐tethered cyclopentenes, affording a library of enantionenriched bicyclo[3.2.1]octadienes in excellent yields and enantioselectivities (mostly >99 % ee). Moreover, the products could undergo an unusual iodination‐induced 1,2‐acyl migration, forming iodinated bicyclo[3.2.1]octadienes with three vicinal stereocenters. The enone and isolated olefin motifs embedded in the products provide useful handles for downstream elaboration.
Stratification of the vertical spread‐skill relation by radiosonde drift in a convective‐scale ensemble
Authors: Flack David L. A. 
Published: November 2023

AbstractEnsemble forecasting systems provide useful insight into the uncertainty in the prediction of the atmosphere. However, most analysis considers ensembles in latitude, longitude, and time. Here, the vertical aspects of the spread‐skill relation are considered in a convective‐scale ensemble via comparisons with radiosonde ascents. The specific focus is on the impact of stratifying the spread‐skill relation by radiosonde drift. The drift acts as a proxy for the mobility of the atmosphere. The overall spread‐skill relation shows the temperature has a better relation than the dewpoint. However, the total variance comparisons between model and observations indicates that the dewpoint is underspread throughout the atmosphere, whilst the temperature is overspread through the lower atmosphere and underspread aloft. This suggests that the model bias is influencing the spread‐skill relation. Stratifying these results by the radiosonde drift indicates that the spread‐skill relation, and model bias, for both temperature and dewpoint degrades with increased mobility. For the most mobile situations, the ensemble is underspread throughout the atmosphere. These results have implications for ensemble design in terms of the role and influence of the driving ensemble in regional systems as more mobile situations will have a stronger dependence on the lateral boundary conditions. Longer term it may also imply that different strategies are required depending on the mobility of the synoptic conditions. Therefore, it argues for more consideration of “on‐demand” ensemble forecasting systems to allow a fairer representation of the uncertainty in different situations.
Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma
Authors: Hou Kai , Xu Xiaohui , Ge Xin , Jiang Jiacen , Ouyang Fan 
Published: November 2023

AbstractImmune checkpoints (ICPs) can promote tumor growth and prevent immunity‐induced cancer cell apoptosis. Fortunately, targeting ICPs, such as programmed cell death 1 (PD‐1) or cytotoxic T lymphocyte associated protein 4 (CTLA‐4), has achieved great success in the past few years and has gradually become an effective treatment for cancers, including hepatocellular carcinoma (HCC). However, many patients do not respond to ICP therapy due to acquired resistance and recurrence. Therefore, clarifying the specific mechanisms of ICP in the development of HCC is very important for enhancing the efficacy of anti‐PD‐1 and anti‐CTLA‐4 therapy. In particular, antigen presentation and interferon‐γ (IFN‐γ) signaling were reported to be involved in the development of resistance. In this review, we have explained the role and regulatory mechanisms of ICP therapy in HCC pathology. Moreover, we have also elaborated on combinations of ICP inhibitors and other treatments to enhance the antitumor effect. Collectively, recent advances in the pharmacological targeting of ICPs provide insights for the development of a novel alternative treatment for HCC.
Association between gut microbial change and acute gastrointestinal toxicity in patients with prostate cancer receiving definitive radiation therapy
Authors: Jang Bum‐Sup , Chung Moon Gyu , Lee Dong Soo 
Published: November 2023

AbstractBackgroundThis prospective study investigated the association between gut microbial changes and acute gastrointestinal toxicities in prostate cancer patients receiving definitive radiation therapy (RT).MethodsSeventy‐nine fecal samples were analyzed. Stool samples were collected at the following timepoints: pre‐RT (prRT), 2 weeks after the start of RT (RT‐2w), 5 weeks after the start of RT (RT‐5w), 1 month after completion of RT (poRT‐1 m), and 3 months after completion of RT (poRT‐3 m). We computed the microbial community polarization index (MCPI) as an indicator of RT‐induced dysbiosis.ResultsPatients experiencing toxicity had lower alpha diversity, especially at RT‐2w (p = 0.037) and RT‐5w (p = 0.003). Compared to patients without toxicity, the MCPI in those experiencing toxicities was significantly elevated (p = 0.019). In terms of predicted metabolic pathways, we found linearly decreasing pathways, including carbon fixation pathways in prokaryotes (p = 0.035) and the bacterial secretion system (p = 0.005), in patients who experienced toxicities.ConclusionsWe showed RT‐induced dysbiosis among patients who experienced toxicities. Reduced diversity and elevated RT‐related MCPI could be helpfully used for developing individualized RT approaches.
Three rare etiologies of urinary retention in pediatrics: A case series and review of the literature
Authors: Hekmati Pooya , Arshadi Hamid , Kamran Hooman , Kajbafzadeh Abdol‐Mohammad , Zahir Mazyar , Amirzargar Hossein , Ghahestani Seyyed Mohammad 
Published: November 2023

Key Clinical MessageEtiology of urinary retention in pediatric age differs significantly from adults and the elderly. Therefore, a comprehensive diagnosis is crucial before specific treatment. Every effort must be made to minimize invasive procedures as far as possible in children.
Non‐osseous intradural tuberculoma of the thoracic spine with compressive myelopathy
Authors: Duvuru Shyam , Sanker Vivek , Naureen Syed , Prakash Gupta , Sanjana Rajurkar , Dave Tirth 
Published: November 2023

Key Clinical MessageAn uncommon form of CNS tuberculosis called non‐osseous IDEM tuberculoma frequently results from paradoxical drug interactions. It should be considered one of the differentials when patients receiving ATT experience acute neurological impairment.AbstractTuberculoma affecting the spinal cord is a rare condition in modern times. The occurrence of non‐osseous intradural tuberculosis, specifically in the spine, is even more exceptional. In fact, it is uncommon to encounter an intradural extramedullary tuberculous granuloma that lacks radiological indications of vertebral involvement, especially within the thoracic region. We present a case of a patient with a neurological deficit caused by a non‐osseous intradural tuberculoma in the thoracic region, without any associated bone involvement. The patient experienced a gradual deterioration of neurological function. An MRI of the thoracic spine revealed the presence of a tuberculoma located intradurally, extramedullary, and juxtamedullary of the T5 vertebra. The compression of the spinal cord resulted in paraparesis which was worsening to paraplegia. A D4–D6 laminectomy and microsurgical excision were performed under intraoperative neurophysiological monitoring (IONM), and the patient showed clinical recovery. Excellent clinical outcomes were achieved. However, it is crucial to consider the possibility of a non‐osseous intradural tuberculoma as a rare condition when encountering a SOL, particularly in patients with a history of tuberculosis and spinal cord compression. In cases where a progressing neurological deficit is present, a combination of surgical intervention and anti‐tuberculous treatment should be considered as the optimal approach.
Recurrent amebic liver abscesses despite metronidazole treatment: A rare case report
Authors: Noveir Sasan D. , Hoang Anh , Li Katherine , Lam John C. , Akkad Khushboo 
Published: November 2023

Key Clinical MessageAmebic liver abscesses should be considered in adult males with a liver abscess and a history of travel to endemic areas. Effective treatment includes metronidazole, followed by paromomycin.
Cobalt‐Catalyzed Hydroalkylation of Alkenes and Alkynes: Advantages and Opportunities
Authors: Liu Bingxue , Liu Qiang 
Published: November 2023

AbstractSp3‐hybridized carbons‐rich molecules play a crucial role in drug discovery. Cobalt‐catalyzed hydroalkylation of alkenes and alkynes is an efficient method to synthesize these compounds. These reactions exhibit a wide range of applicability and high tolerance for functional groups, utilizing readily available alkenes and alkynes instead of hyperactive metallic reagents. Herein, we summarize the advancements of cobalt‐catalyzed hydroalkylation of alkenes and alkynes, according to different reaction mechanisms. We present a detailed discussion of the scope and limitations, plausible mechanisms and the opportunities for further development.
Modulating Cation and Water Transports for Enhanced CO Electrolysis via Ionomer Coating
Authors: Adnan Muflih A. , Nabil Shariful Kibria , Kannimuthu Karthick , Kibria Md Golam 
Published: November 2023

AbstractElectrification of the chemical industry has been considered an enabler for energy transition on a massive scale. In this context, carbon monoxide electroreduction (COR) to produce multi‐carbon (C2+) products is considered one of the forefront emerging technologies. The key challenge in COR comes from the excessive cation crossover to the cathode via electromigration and water diffusion, which limits CO availability and impedes product selectivity. Commercial anion exchange membrane (AEM) suppresses the electromigration of cations, however, suffers from water diffusion which facilitates cation crossover. Here, we tackled these problems emerging from cation crossover and water diffusion by directly depositing an ultrathin Nafion ionomer on the cathode (sputtered Cu) surface. Our approach enables full‐cell energy efficiency of 21 % for converting CO into ethylene (C2H4) at 100 mA/cm2 with over 200 hours of stable operation. We also exhibited record high energy efficiency for ethanol (C2H5OH) production with CO‐to‐C2H5OH electrolysis efficiency of 17 %. This approach to directly depositing ultrathin ionomer on the cathode to enhance system performance may benefit other electrochemical systems to overcome challenges associated with scalability, stability, and efficiency to produce high‐value chemicals.
Driver behaviour prediction and enhanced ad hoc on‐demand distance vector routing protocol in VANET
Authors: Swamynathan Cloudin , Ravi Vidhya , Ranganayakulu Dhanalakshmi , Kandasamy Ramesh 
Published: November 2023

SummaryMobility pattern recognition is a complex task in vehicle ad hoc networks (VANET) because the driving state of each vehicle is different. An intelligent transportation system on VANET is used for traffic control and accident prevention. For this reason, human driver behaviour is first analysed to identify mobility patterns. A novel driver behaviour prediction model using a Siamese deep learning architecture is proposed to achieve the goal. Here, an image‐based behaviour prediction model is performed to achieve the highly accurate driving state of the driver. A warning message is forwarded to the neighbouring vehicles based on the driver's behaviour. Due to the dynamic properties of real‐time vehicle mobility, a faster data transmission model is achieved using the ad hoc on‐demand distance vector routing protocol. To achieve faster data transmission and nullified retransmission, here a weighted location‐based routing model is framed. The optimization problem in the location‐aided routing protocol is solved using the vector algorithm's weighted mean. As a result, the proposed method improved the throughput of ASHLOSR to 8.1% and AODV to 7.6%.