bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate-forced Hg-remobilization driving mutagenesis in ferns in the aftermath of the end-Triassic extinction
Authors: Bos Remco , Zheng Wang , Lindström Sofie , Sanei Hamed , Waajen Irene , Fendley Isabel , Mather Tamsin , Wang Yang , Rohovec Jan , Navrátil Tomáš , Sluijs Appy , de Schootbrugge Bas van 
Published: October 2023

Abstract

The long-term effects of the Central Atlantic Magmatic Province (CAMP), a large igneous province connected to the end-Triassic mass-extinction (201.5 Ma), remain largely elusive. Here, we document the persistence of volcanic-induced mercury pollution and its effects on the biosphere for 2 million years after the extinction event. In sediments recovered in Germany (Schandelah-1 core), we record not only high abundances of malformed fern spores at the Triassic-Jurassic boundary, but also during the Hettangian, indicating repeated vegetation disturbance and environmental stress that was eccentricity forced. Crucially, these abundances correspond to spikes in sedimentary Hg concentrations. Hg-isotope ratios (δ202Hg, Δ199Hg) indicate a volcanic source at the Triassic-Jurassic boundary but a terrestrial source for the early Jurassic peaks. We conclude that Hg injected by CAMP across the extinction was repeatedly remobilized from coastal wetlands and hinterland areas during eccentricity-forced phases of severe hydrological upheaval and erosion, focusing Hg-pollution in shallow marine basins.
Impact of Gadgets on Amblyopic Therapy and Risk of Astigmatism Development: A Prospective Case Report of 5 years old child.
Authors: Shah Mutahir , Ullah Saif 
Published: October 2023

Abstract
This prospective case report was carried out to investigate the effect of electronic gadget use during amblyopic therapy in a 5-year-old child with monocular hyperopia of +6DS. The child received glasses and underwent patching therapy for the amblyopic left eye while using electronic devices. The therapy successfully improved visual acuity over two years, an unexpected development of with-the-rule astigmatism in the left eye raised concerns about the role of gadget use in astigmatism development. This prospective case report highlights the efficacy of patching therapy combined with gadget, but suggests the need for further investigation of the potential risks of developing astigmatism.
The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer
Authors: Liu Songhua , Rong Yao , Tang Mingzheng , Zhao Qiqi , Li Chunyan , Gao Wenbin , Yang Xiaojun 
Published: October 2023

:
Gastric cancer (GC) is one of the most common malignancies worldwide. Despite significant
advancements in surgical and adjuvant treatments, patient prognosis remains unsatisfactory.
Long non-coding RNAs (lncRNAs) are a class of RNA molecules that lack protein-coding capacity
but can engage in the malignant biological behaviors of tumors through various mechanisms.
Among them, small nucleolar host genes (SNHGs) represent a subgroup of lncRNAs. Studies have
revealed their involvement not only in gastric cancer cell proliferation, invasion, migration, epithelial-
mesenchymal transition (EMT), and apoptosis but also in chemotherapy resistance and tumor
stemness. This review comprehensively summarizes the biological functions, molecular mechanisms,
and clinical significance of SNHGs in gastric cancer. It provides novel insights into potential
biomarkers and therapeutic targets for the exploration of gastric cancer.
Early Detection of Colorectal Cancer: Conventional Techniques and Current
Biomarkers
Authors: Ahmadpour Sajjad , Habibi Mohammad Amin , Pashaei Mohammad Reza , Mohammadpour Yousef , Jazi Kimia , Modarres Mehdi Pezeshgi 
Published: October 2023

Abstract:
Colorectal cancer (CRC) is the third most common cancer worldwide, and the incidence of
CRC seems to increase gradually. The survival of CRC varies in different countries, attributed to the
screening program. Generally, diagnostic approaches for CRC can be divided into visual detection
methods and laboratory methods. Colonoscopy, sigmoidoscopy, and computed tomography colonography are considered visual methods widely used in cancer detection. Although visual methods
provide some benefits, some disadvantages such as late detection, are present, making them useless in
rapidly progressing CRC patients. On the other hand, laboratory tests are developed to compensate
for the disadvantages of visual methods. More recent progression in laboratory tests makes them able
to superfine detection of CRC. For instance, molecular and genetic methods based on the components
of cancer cells, like nucleic acid and proteins, can prognosticate further cancer development in susceptible patients. Alongside new therapeutic approaches developed within decades, the number of
CRC detection methods has increased, which aims to reduce the duration between cancer initiation
and detection. This review sought to survey the CRC detection methods, including conventional and
recently-developed methods, to provide better insight into CRC screening.
An Overview of Diabetic Cardiomyopathy
Authors: Quaiyoom Abdul , Kumar Ranjeet 
Published: October 2023

Abstract:
Diabetic cardiomyopathy (DCM) is a myocardial disorder that is characterised by
structural and functional abnormalities of the heart muscle in the absence of hypertension, valvular heart disease, congenital heart defects, or coronary artery disease (CAD). After witnessing a
particular form of cardiomyopathy in diabetic individuals, Rubler et al. came up with the moniker diabetic cardiomyopathy in 1972. Four stages of DCM are documented, and the American
College of Cardiology/American Heart Association Stage and New York Heart Association
Class for HF have some overlap. Diabetes is linked to several distinct forms of heart failure.
Around 40% of people with heart failure with preserved ejection fraction (HFpEF) have diabetes, which is thought to be closely associated with the pathophysiology of HFpEF. Diabetes and
HF are uniquely associated in a bidirectional manner. When compared to the general population
without diabetes, those with diabetes have a risk of heart failure that is up to four times higher. A
biomarker is a trait that is reliably measured and assessed as a predictor of healthy biological activities, pathological processes, or pharmacologic responses to a clinical treatment. Several biomarker values have been discovered to be greater in patients with diabetes than in control subjects among those who have recently developed heart failure. Myocardial fibrosis and hypertrophy are the primary characteristics of DCM, and structural alterations in the diabetic myocardium are often examined by non-invasive, reliable, and reproducible procedures. An invasive
method called endomyocardial biopsy (EMB) is most often used to diagnose many cardiac illnesses.
A Narrative Review on the Potential of Black Seeds (Nigella Sativa) in the
Management of West Nile Virus Infection
Authors: Maideen Naina Mohamed Pakkir , Balasubramanian Rajkapoor , Shanmugam Arun 
Published: October 2023

Abstract:
West Nile virus (WNV) infection is a mosquito-borne illness that is endemic to Africa,
Asia, the Middle East, Australia, and Europe. WNV-infected individuals can only be managed
with symptomatic therapy and supportive care at this point of time. Thus, we have analyzed the
possible beneficial effects of black seeds (N. sativa) in this literature review. To find relevant articles,
various online databases, such as the Web of Science, Medline, PMC, PubMed, Embase, EBSCO,
Google Scholar, Science Direct, and reference lists were searched. The antiviral, analgesic,
anti-inflammatory, antioxidant, and immunomodulatory effects of black seeds (N. sativa) have
been established by numerous clinical, animal, in vivo, in vitro, and in silico studies. It has been
found that black seeds (N. sativa) have the potential to be included as adjuvant therapy in addition
to symptomatic treatment and supportive care in the early stages of WNV infection once randomized
controlled clinical trials (RCTs) affirm the safety and efficacy of black seeds (N. sativa)
in WNV infection management as they have been considered the gold standard of treatment in
clinical studies.
The values of leadership in badminton game
Authors: Komari Amat , Sugiyono Sugiyono , Siswantoyo Siswantoyo , Dwi Marhaendro Agus Susworo , Suhadi Suhadi , Solikhin Muhamad Nanang , Sadewa Yanuar Rachman 
Published: October 2023

The values in sport settings have long been discussed in the literature, including the ones in the context of badminton. Despite there have been many leadership values in the literature, there is no explicit leadership value coming from research in badminton. Therefore, the purpose of the current study was to investigate the values of leadership being learned from the badminton game and develop value products through Research and Development. The research method used was a mixed method. Participants of the study included 7 former badminton players having leadership positions and 122 students in physical education teacher education program. Data were collected through in-depth interviews and survey. The results of these interviews were then interpreted, reduced, and given codes so that the values of leadership in badminton were obtained converging. The results of the research on leadership values in badminton games included (1) knowing the boundaries of territory (2) realizing the limits of authority (3) working together (4) obeying rules (5) keeping secrets (6) depth of knowledge (7) elegant decisions (8) obeying superiors (9) act with heart. The value products have been implemented and measured their effectiveness. It concludes that badminton provides opportunities to learn and develop leadership competencies. The value products are effective as a model for teaching leadership through badminton.
ETHNOMATHEMATICS IN STRUCTURE AND CARVING PATTERNS OF TORAJAN TRADITIONAL HOUSE BUILDING
Authors: Sari Lidia Widia 
Published: October 2023

Toraja is one of the tribes in South Sulawesi, precisely in Tana Toraja. The Tana Toraja people are very famous for their strong cultural customs; there are so many spiritual activities, a series of traditional ceremonies, and cultures that are still very well preserved among the local community. Tongkonan is a Torajan traditional house building that is very popular and always attracts attention, including people from outside Tana Toraja, because the shapes and motifs of the carvings are unique; the shapes and motifs of these carvings cannot be separated from mathematical elements. This study is aimed at identifying the ethnomathematics contained in the carving patterns of the Tongkonan traditional house building. The research was qualitative with a descriptive method. The data collection technique used was a literature study. Results indicate that ethnomathematics in the structure of carving patterns on the Torajan traditional houses building can be integrated into various models of mathematics learning.
Unfolded protein response in gastric glandulocytes of rats with the pharmacological correction of type 2 diabetes
Authors: Klys Y.G. , Kerimov T.R. , Savosko S.I. , Osadchuk Y.S. , Smirnov S.M. , Natrus L.V. 
Published: October 2023

Background. The cellular and molecular mechanisms underlying gastrointestinal complications caused by type 2 diabetes mellitus (T2DM) may involve accumulation of misfolded proteins in the endoplasmic reticulum that disrupts protein homeostasis and activates a signaling pathway termed the unfolded protein response (UPR). The goal of the present study was to assess the state of the UPR system in gastric glandulocytes of untreated and metformin- and propionate-treated T2DM rats. Materials and methods. Rats with induced T2DM received metformin, propionate, and their combination. Analysis of the levels of 78-kDa glucose-regulated protein (GRP78), activating transcription factor 6 (ATF6), protein kinase R-like endoplasmic reticulum kinase (PERK), and inositol-requiring enzyme 1 (IRE1) was performed by Western blotting and immunohistochemical assessment of slices. Results. In T2DM rats, an increase in GRP78 vs. control (normal) group was found. Metformin and propionate treatment led to an increase in GRP78; under combination therapy, its content was registered at the level in untreated T2DM group. An increase in the ATF6 in T2DM rats was found, and all treatment regimens contributed to its growth. The PERK level in T2DM rats exceeded that in controls, and propionate treatment caused its decrease to the level observed in control group. An immunohistochemical assessment revealed a tendency to increase the intensity of immunoreaction for GRP78 in T2DM rats. With metformin treatment, an intensive immunoreaction for GRP78 was revealed. The general trend in T2DM rats was a significant increase in ATF6 expression. Conclusions. Combination treatment with metformin and propionate led to a significant decrease in GRP78, which may indicate a positive effect of such therapy. New data on propionic acid effect on UPR in the stomach have been obtained that may be beneficial for developing possible treatment strategies in complications of gastropathy caused by diabetes.
The level of pancreatic fecal elastase-1 and the risk of cardiovascular complications in patients with chronic pancreatitis combined with arterial hypertension
Authors: Filippova A.Yu. , Kryvoshei V.V. 
Published: October 2023

Background. Chronic pancreatitis and malnutrition are associated with cardiovascular diseases and cardiovascular events, while the role of exocrine pancreatic insufficiency as a risk factor for cardiovascular events is unknown. The purpose of the study was to evaluate the level of pancreatic fecal elastase-1 in patients with chronic pancreatitis combined with hypertension and to determine the relationship with cardiovascular risk. Materials and methods. One hundred and ten patients (46 men, 64 women) aged 45–65 years with chronic pancreatitis were included in the study. The first group consisted of people with a combined course of chronic pancreatitis and hypertension; the second — with chronic pancreatitis alone. The levels of total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very low-density cholesterol, pancreatic fecal elastase-1, total protein, serum content of albumin, iron, vitamin D, zinc and magnesium were evaluated in all patients. Results. In the group 1, there were significantly more cases of severe exocrine pancreatic insufficiency and a significantly lower number of patients with a normal level of pancreatic fecal elastase-1 (p < 0.05). In addition, a very high cardiovascular risk was detected significantly more often in this group — 11.5 % (p < 0.05). The main cardiovascular risk factors among patients with chronic pancreatitis, in addition to hypertension, included obesity and increased body weight — 70.9 % of cases. Elevated levels of TG, LDL, and total cholesterol were observed in 86.4, 94.5, and 91.8 % of patients with chronic pancreatitis combined with hypertension, respectively, and a reduced content of HDL-C was found in 34.5 % (p < 0.05). Significantly higher levels of TG, LDL-C, total cholesterol, and a lower level of HDL were revealed in the group 1 compared to the group 2 (p < 0.05). In patients of the group 1, a reliable inverse correlation was found between the pancreatic fecal elastase-1 and TG, atherogenic index, the SCORE2 scale (r = –0.43, p < 0.05; r = –0.52, p < 0.05; r = –0.48, p < 0.05, respectively), as well as a reliable direct correlation with HDL level (r = 0.50; p < 0.05). Conclusions. The combined course of chronic pancreatitis with exocrine pancreatic insufficiency and hypertension is associated with an increased cardiovascular risk. A decrease in the level of pancreatic fecal elastase-1 and malnutrition may be associated with an increase in the frequency of dyslipidemia and in the risk of cardiovascular events among these patients.
Spectrophotometric Determination of Trace Quantities of Pure Atropine and Pharmaceutical Preparations with SbI<sub>4</sub><sup>2−</sup> Ion
Authors: Ali Riyadh Hasan Mohammed , Abdullah Bashar Mudhaffar , Ahmed Rasha Ismail 
Published: October 2023

This study aims to estimate a simple, rapid and sensitive method for a trace amount of atropine (ATR) in medicinal compounds. Two approaches were followed to accomplish this aim, i.e., spectrophotometric determination of pure ATR and pharmaceutical preparations using SbI42− ion as a new reagent. The procedure involves the implementation of an ion-association complex with this alkaloid. The resulting complex was extracted and detected spectrophotometrically at 492 nm. Appropriate parameters were investigated, including the ion SbI42− concentration and the pH value of the complex formation. Using chloroform to extract the complex, taking into consideration extraction time and volume of solvent used. The calibration graph is linear in the ranges of 0.5–5.0 × 10−3 M. Precision, accuracy, detection limit, and RSD %, as well as relative standard deviation (n = 5), were calculated. The test sensitivity was 0.013 µg cm−2. Several interference additives were studied by investigating the effect of equal and duplicate quantities of some common excipients on selectivity, such as starch, glucose, lactose, glycerin, and talc. The molar ratio of the SbI42−_ATR was determined. The amount of ATR in the pharmaceutical tablets and eye drop preparation was calculated using Erel at ratios of 2.24 and 2.75%, respectively.
Volatile Organic Compounds and Antioxidant, Cytotoxic Activities of Extracts from the Leaves of <i>Grewia bulot</i>
Authors: Pham Ty Viet , Ho Duc Viet , Le Anh Tuan , Ngo Y Duy , Dang Nhan Thi Thanh , Le Thang Quoc , Nguyen Bao Chi 
Published: October 2023

This research aims to determine the volatile compounds present in Grewia bulot leaf extracts and evaluate their cytotoxic and antioxidant activities. The volatile constituents of the n-hexane and dichloromethane extracts were identified by using gas chromatography–mass spectrometry. The main compounds identified in the former were neophytadiene (18.2%), methyl palmitate (14.4%), methyl linoleate (9.7%), β-sitosterol (4.5%), and methyl stearate (3.4%), while those in the latter were palmitic acid (9.8%), hexadecane (7.4%), octadecane (6.0%), neophytadiene (5.3%), and 2-tert-butoxyethanol (5.3%). The cytotoxicities of the extracts were examined against four human cancer cell lines (SK-LU-1, Hep-G2, MCF-7, and KB), while their antioxidant activities were assessed using the DPPH radical scavenging assay. The n-hexane and dichloromethane extracts displayed weak activity against these cancer cell lines, with IC50 values ranging from 90.60 ± 3.49 to 98.27 ± 2.77 µg/mL. All extracts showed antioxidant activities, and the methanol extract exhibited the strongest at an SC50 value of 9.39 ± 0.90 µg/mL. This is the first report on the volatile constituents and bioactivities of G. bulot leaf extracts, suggesting their potential application as antioxidants.
Enhancing the CO<sub>2</sub> Adsorption Performance of UiO-66 by Imidazolium-Based Room-Temperature Ionic Liquids (RTILs) Incorporation
Authors: Mukaromah Laela , Haryanto Andi , Permana Yessi , Patah Aep 
Published: October 2023

Functionalization of metal-organic frameworks resulting in efficient CO2 adsorption materials became substantial in preventing the worsening environment upon the emission of CO2. In this study, several room-temperature ionic liquids (RTILs) with an imidazolium-based cation of 1-butyl-3-methylimidazolium [bmim]+ and anions of bis(trifluoromethylsulfonyl)imide [TFSI]−, trifluoromethanesulfonate [OTf]−, hexafluorophosphate [PF6]−, and tetrafluoroborate [BF4]− were incorporated into UiO-66 by wet impregnation method under air. The RTILs/UiO-66 composites were characterized by PXRD, FTIR, TGA, nitrogen physisorption, and CO2 adsorption. Based on the type of anions of imidazolium-based RTILs, the CO2 uptake of RTILs/UiO-66 composites followed the trend: [OTf]− > [TFSI]− > [PF₆]− > [BF₄]− at low temperature (273 K) and pressure (100 kPa). The CO2 uptake of pristine UiO-66 increased approximately 1.5 times upon incorporating [bmim][OTf]. The type of anions of imidazolium-based RTILs influences the CO2 adsorption performance of RTILs/UiO-66 composites in which anions containing fluoroalkyl group ([OTf]−, [TFSI]−) exhibited a higher CO2 uptake compared to inorganic fluorinated anions ([BF4]−, [PF6]−). Hence, the incorporation of hydrophobic imidazolium-based RTILs showed a potential to enhance the performance of UiO-66 for CO2 adsorption application.
Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes
Authors: Gimblet Colin J. , Kruse Nicholas T. , Geasland Katharine , Michelson Jeni , Sun Mingyao , Mandukhail Safur Rehman , Wendt Linder H. , Eyck Patrick Ten , Pierce Gary L. , Jalal Diana I. 
Published: October 2023

Background
Patients with CKD and diabetes are at higher risk of developing cardiovascular disease, in part, because of impaired endothelial function. Cardioprotective compounds such as resveratrol could improve endothelial function and attenuate the cardiovascular burden in patients with CKD and diabetes. We hypothesized that resveratrol supplementation would improve endothelial function in patients with CKD and diabetes.

Methods
Twenty-eight adults aged 68±7 years (84% men) with stage 3 CKD and diabetes were enrolled in a randomized, double-blind, placebo-controlled, crossover study to investigate the effects of 6-week resveratrol supplementation (400 mg/d) on endothelial function. Endothelial function was determined through brachial artery flow-mediated dilation.

Results
The mean values for eGFR and hemoglobin A1c were 40±9 ml/min per 1.73 m2 and 7.36%±0.72%, respectively. Compared with placebo, resveratrol supplementation increased flow-mediated dilation (ratio of geometric mean changes and 95% confidence interval for between-group comparisons, 1.43 (1.15 to 1.77); P value = 0.001). eGFR, hemoglobin A1c, BP, and nitroglycerin-mediated dilation were unchanged with resveratrol or placebo (P = 0.15), suggesting the observed change in flow-mediated dilation was likely independent of changes in traditional cardiovascular risk factors.

Conclusions
Resveratrol supplementation improved endothelial function in patients with CKD and diabetes.

Clinical Trial registry name and registration number
Resveratrol and Vascular Function in CKD, NCT03597568.