bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathogenic and clinical features of neonatal bacterial conjunctivitis in southern China: a retrospective study
Authors: Luo Yasha , Gu Chunming , Sun Yuanxin , Guo Junfei , Lai Weiming , Deng Wenyu , Wu Yongbing , Luo Mingyong 
Published: January 2024

Abstract

Background: Bacterial conjunctivitis is one of the most common ocular problems of neonates. The aim of this study was to retrospectively analyse the clinical and pathogenic characteristics of neonatal bacterial conjunctivitis in southern China from 2017 to 2021.
Methods: Clinical and microbiological data of neonates with culture-proven bacterial conjunctivitis in our hospital were retrospectively collected from January 2017 to December 2021. Then, the distribution of the pathogens, the clinical characteristics and the antimicrobial susceptibility patterns were evaluated.
Results: Bacteria was separated from 299 samples (30.9%) out of the 967 samples assessed, and 8 patients were infected by two bacteria. A total of 307 pathogens were identified, of which 211 (67.2%) were Gram-positive, and 96 (30.1%) were Gram-negative. S. aureus (53.7%) was the most frequent causative organism, followed by C. macginleyi (10.7%) and E. coli (10.1%). Only one case of N. gonorrhoeae was isolated. An increasing detection rate during the last five years (χ2=16.68, P<0.001) was observed, and a similar trend was found in Gram-positive bacteria (χ2=9.898, P=0.002). Gram-negative bacteria related neonatal conjunctivitis were common among neonates suffered turbid amniotic fluid. Fifty-two S. aureus isolates (34.2%) were methicillin-resistant S. aureus (MRSA) and 5 strains (15.6%) E.coli were extended spectrum b-lactamases (ESBLs) producing bacteria. All S. aureus and C. macginleyi strains are susceptible to vancomycin and linezolid, and E. coli are susceptible to imipenem, ertapenem and amikacin.
Conclusion: Although most of neonatal bacterial conjunctivitis are self-limiting disease, investigating the pathogenic characteristics and antibiotics parttern may help to shorten the duration of conjunctival symptoms in neonates with acute bacterial conjunctivitis.
Development and validation of a scale to measure the care needs of Crohn's Disease Patients
Authors: Chen Danlei , Pan Ting , Liu Qing , Yu Zhihui , Zhang Ailing , Chen Yan , Kong Fang , Ding ChengLiang 
Published: January 2024

Abstract
Background
Crohn's disease (CD) patients require varying levels of supportive care. In order to facilitate caregivers and nurses in precisely evaluating the caregiving requirements of these patients, we developed the CD-specific Care Needs Scale (CD-CNS).
Methods
Qualitative interviews were conducted based on the supportive care needs framework and Maslow's hierarchy of needs, and scale items were constructed through a literature search and qualitative interviews. The initial version of the scale with 45 items was obtained after the items were verified and modified by expert consultation. A total of 250 CD patients admitted to the gastroenterology department of a hospital in China were selected for verification of the initial version of the scale. A self-designed general questionnaire was used to obtain patients' medical history and sociodemographic data, and the Chinese version of the IBDQ was used as the criterion. Exploratory factor analysis (EFA) was performed on the CD-CNS to evaluate the dimensions, factor structure, reliability, criterion validity, and construct validity.
Results
EFA identified 5 dimensions and retained 27 items with strong internal consistency reliability (α = 0.94). The Cronbach's α coefficients for each dimension ranged from 0.824–0.921. Criterion validity was assessed using Spearman's coefficient, which demonstrated a significant correlation with the IBDQ (P < 0.050). The test-retest reliability for each dimension after two weeks ranged from 0.824–0.895.
Conclusions
We developed and validated a new scale that can be used to assess the care needs of CD patients. This new tool can guide the specific supportive care of CD patients.
Trial registration:
This study was reviewed and approved by the Ethics Committee of the Second Hospital of Nanjing (2021-LS-ky-022). It was duly registered and approved online through the Trial Center of the Second Hospital of Nanjing in 2021. Confidentiality was ensured by anonymizing all data. The entire study process was conducted under the supervision of the Ethics Committee of Nanjing Second Hospital. Informed consent was obtained from the patients, and each patient volunteered and agreed to participate.
Designing of Airspeed Measurement Method for UAV Based on MEMS Pressure Sensors
Authors: chen zhipeng , Li Haojie , Yu Hang , Zhao Yuan , Zhang Chuanhao , Zhang He 
Published: January 2024

Abstract

Airspeed measurement is crucial for UAV control. To achieve accurate airspeed measurements for UAV, this paper calculates airspeed data by measuring changes in air pressure and temperature. Based on this, a data processing method based on mechanical filtering and improved AR-SHAKF algorithm is proposed to indirectly measure airspeed with high precision. In particular, a mathematical model for an airspeed measurement system is established, and an installation method for the pressure sensor is designed to measure the total pressure, static pressure and temperature. Secondly, the measurement principle of the sensor are analyzed, and a metal tube is installed to act as a mechanical filter, particularly in cases where the aircraft has a significant impact on the gas flow field. Furthermore, a time-series model is used to establish the sensor state equation and the initial noise values. It also enhances the Sage-Husa adaptive filter to analyze the unavoidable error impact of initial noise values. By constraining the range of measurement noise, it achieves adaptive noise estimation. To validate the superiority of the proposed method, a low-complexity airspeed measurement device based on MEMS pressure sensors is designed. The results demonstrate that the airspeed measurement device and the designed velocity measurement method can effectively calculate airspeed with high measurement accuracy and strong interference resistance.
Mechanism of geraniol against E. coli infection by regulating YDIV
Authors: Long Nana , Dai Min , Wang Yuzhen , Zhang Yanjiao , Guo Wei , Pu Zhonghui 
Published: January 2024

Abstract
Purpose
Geraniol, an active component found in the essential oil of various medicinal plants, possesses a wide range of antibacterial properties, including against E. coli. Nevertheless, the precise inhibitory mechanism of geraniol on E. coli remains elusive.
Methods
Co-cultivation of multidrug-resistant Escherichia coli with geraniol was performed to investigate changes in biomass, gene expression, intracellular iron concentration, phagocytic activity, and complement-mediated killing ability. Additionally, protein expression alterations were assessed to evaluate the regulatory effects of geraniol.
Results
The compound geraniol demonstrated a downregulation of ydiv and iron metabolism gene fepA, fecB and fhuF expression. Concomitantly, it was observed that linalool led to a decrease in intracellular iron ion concentration. Meanwhile, treatment of E. coli with geraniol resulted in a downregulation of ompW gene expression. Additionally, it led to a decrease in the killing ability of antiserum complement and an increase in the phagocytic capacity of macrophages. Furthermore, geraniol demonstrated augmented binding effects, possibly facilitated through hydrogen bonding, relying on structural simulation or MST.
Conclusion
These results suggested for the first time that geraniol by regulating the iron transport-related proteins YdiV, thereby decreasing the ability of antiserum complement, and an increase in the phagocytic capacity of macrophages exerting inhibited E. coli.
Evolutionary and Synteny Analysis of BADH2, GBSS1, GBBS2, and HIS1 in Rice: Insights for Effective Introgression Breeding Strategies
Authors: Lim Insu , Park Yong-Jin , Ha Jungmin 
Published: January 2024

Abstract
The key genes BADH2, GBSS1, GBSS2, and HIS1 regulate the fragrance, starch synthesis, and herbicide resistance in rice. Although the molecular functions of four genes have been investigated in the Oryza sativa species, little is known regarding their evolutionary history in the Oryza genus. Here, we studied the evolution of four focal genes in 10 Oryza species using phylogenetic and syntenic approaches. The HIS1 family underwent several times of tandem duplication events in the Oryza species, resulting in copy number variation ranging from 2–7. At most one copy of BADH2, GBSS1, and GBSS2 orthologs were identified in each Oryza species, and gene loss events of BADH2 and GBSS2 were identified in three Oryza species. Gene transfer analysis proposed that the functional roles of GBSS1 and GBSS2 were developed in the Asian and African regions, respectively, and most allelic variations of BADH2 in japonica rice emerged after the divergence between the Asian and African rice groups. These results provide clues to determine the origin and evolution of the key genes in rice breeding as well as valuable information for molecular breeders and scientists to develop efficient strategies to simultaneously improve grain quality and yield potential in rice.
Time-Frequency Connectedness in Global Banking: Volatility and Return Dynamics of BRICS and G7 Banks
Authors: Dammak Wael , Gökgöz Halilibrahim , Jeribi Ahmed 
Published: January 2024

Abstract

Addressing recent disturbances in the global financial landscape, this paper investigates volatility and return spillovers within the banking indices of BRICS and G7 countries using a time-varying parameter autoregressive model. We analyze daily bank stock indices from January 2018 to October 2023, focusing on the role of interconnectedness in shaping global financial stability, particularly during significant events. Our empirical findings shed light on the dynamic nature of volatility and return spillovers between the banking sectors of these countries. These interconnections are notably influenced by specific countries and are significantly affected by turbulent events. The connectedness among the indices shows varying patterns across different time frequencies, with short-term (1–5 days) and intermediate-long term (5 days to infinity) connectedness displaying distinct characteristics, especially during periods of global shocks. This heterogeneity underscores the complexity of financial market responses over different time horizons during crises. The study reveals that the connectedness among these indices is dynamic, showing considerable changes over time. We find that national banking indices frequently switch roles, oscillating between being net transmitters and receivers of volatility. This finding emphasizes the need to account for the varied impacts of global events on financial markets across different time frames. The research highlights the critical importance of understanding the interconnectedness in global banking markets and advocates for a dynamic approach by investors and policymakers in financial markets, stressing the necessity to adapt strategies to the continuously evolving market scenarios.
The attitude of Maths teachers in England and Egypt towered using E- tools during the School Closure during the Covid-19 Pandemic
Authors: Harb Mahmoud 
Published: January 2024

Abstract
This research, focused on education, presents a comparative case study investigating the challenges and impacts of teaching math remotely during the COVID-19 lockdown. The study examines math teachers' experiences in schools in Egypt and England, exploring the use of e-tools for remote instruction and its effects on various aspects of the teaching and learning process. Utilising a case study methodology, the research provides a detailed analysis of teachers' experiences in both contexts, capturing their reflections and observations. By comparing teachers' experiences in Egypt and England, the study aims to identify similarities and differences in the challenges and impacts of remote math instruction during the COVID-19 lockdown. The comparative case study sheds light on key challenges teachers faces in both countries, including student attendance, engagement, assessment, incomplete coverage of the curriculum, and deviations from the planned curriculum map. It explores the contextual factors that influence these challenges, such as disparities in technology access, cultural and educational norms, and policy responses to the pandemic. Through the comparative analysis, the research offers insights into the unique challenges and adaptations made by teachers in each country. It highlights the importance of considering local contexts and educational systems when designing strategies for remote math instruction during times of crisis. Findings from the comparative case study contribute to the broader field of education by providing a nuanced understanding of the challenges and impacts of remote teaching and learning in math education. The research underscores the need for context-specific approaches, considering students' and teachers' diverse needs and resources in different educational settings. By examining the experiences of math teachers in Egypt and England, this research informs educational practitioners, policymakers, and researchers about effective strategies and best practices for remote math instruction. It emphasizes the importance of collaboration and knowledge exchange across international borders to enhance the quality of education during challenging circumstances like the COVID-19 lockdown.
Causal association of chronic diseases with herpes zoster and postherpetic neuralgia: a two-sample Mendelian randomization study
Authors: Luan Shuwei , Wang Yan , Li Qing , Zheng Xiaojun , Shang Nan 
Published: January 2024

Abstract

Background
The incidence of herpes zoster and postherpetic neuralgia is higher in people with compromised immune function. This study aimed to explore whether there is a causal correlation between different types of chronic diseases and herpes zoster and postherpetic neuralgia using two-sample Mendelian randomization (MR) analysis.
Methods
Phenotypic single-nucleotide polymorphisms (SNPs) associated with chronic diseases (obesity, hypertension, type 2 diabetes, rheumatoid arthritis, systemic lupus erythematosus, asthma, hyperlipidemia, depression, stroke, ischemic stroke, coronary heart disease, and chronic kidney disease) and herpes zoster were obtained from publicly available databases or published genome-wide association studies (GWAS) and used as genetic instrumental variables. SNPs were examined for strength, horizontal pleiotropy, and heterogeneity. The results of MR were based on inverse variance weighted (IVW) analysis and expressed as odds ratio (OR) with 95% confidence interval (CI).
Results
Our findings demonstrated that genetically predicted ischemic stroke [IVW: OR = 1.420 (95%CI: 1.044–1.933), P = 0.0256] increased the risk of herpes zoster. Furthermore, genetically predicted obesity [IVW: OR = 1.851 (95%CI: 1.058–3.239), P = 0.0311] and type 2 diabetes [IVW: OR = 1.685 (95%CI: 1.023–2.775), P = 0.0404] were associated with an increased risk of postherpetic neuralgia. No significant causal relationship was observed between genetically predicted other chronic diseases and the risk of herpes zoster and postherpetic neuralgia (P > 0.05).
Conclusion
This study found a causality for ischemic stroke-herpes zoster, obesity- postherpetic neuralgia, and type 2 diabetes-postherpetic neuralgia.
The effects of familiarity, degree of controllability and varying contents of the environment to embodied and emotional experiences in virtual nature
Authors: Lau Joyce S.Y. , Hui Ho Yin , Kwong Ka Long , Lam Wing Tung , Lau Ho Sum , Yeung Cheuk Lam , Zhong Junpei 
Published: January 2024

Abstract
This study aimed to investigate the relations of emotion, relaxation and embodied experiences by providing the Virtual Reality (VR)-based nature. 31 participants without a clinical diagnosis of mental illness were invited to attend VR sessions to view natural sceneries under different levels of controlling the VR equipment. Participants’ mood states, experiences of embodiment and presence, and sickness induced in the sessions were evaluated after the sessions using the profile of mood states scale (POMS), the experience of embodiment scale (EES), the connectedness to nature scale (CNS), the presence questionnaire (PQ), and the simulator sickness questionnaire (SSQ). The results showed a significant difference in mood and experience of embodiment before and after viewing VR sceneries. There was a significant difference in emotions and embodiment before and after the VR sessions. This suggests that VR sceneries have potential to be applied in treatment of mood disorders. In contrast, no significant finding was found in emotions and embodiment when the VR contents or the degree of controllability were changed, nor among groups with different familiarities with sceneries. Overall, the findings show the VR sceneries may be useful for mental health. Future study for a more comprehensive investigation is recommended.
Clinical Association Between Immune-Related Adverse Events and Treatment Efficacy in Non-Small Cell Lung Cancer Patients Treated with Nivolumab plus Ipilimumab-Based Therapy
Authors: Ebi Noriyuki , Inoue Hiroyuki , Igata Fumiyasu , Okuma Rei , Kinoshita Eriko , Kawabata Toshiaki , Tan Ibun , Osaki Yusuke , Ikeda Takato , Nakao Akira , Shundo Yuki , Hamada Naoki , Fujita Masaki 
Published: January 2024

Abstract

Nivolumab and ipilimumab combination therapy, explored for advanced non-small cell lung cancer (NSCLC) in trials like CheckMate 227 and CheckMate 9LA, raises questions about the relationship between immune-related adverse events (irAEs) and treatment efficacy in real-world settings. In our retrospective analysis of 28 advanced or recurrent NSCLC patients treated with nivolumab plus ipilimumab (with/without platinum-doublet chemotherapy) from February 2021 to January 2023, we aimed to understand the clinical association between irAEs and treatment efficacy. Among the 28 patients, 22 (78.6%) experienced irAEs. Patients with irAEs demonstrated significantly longer median progression-free survival (PFS) and overall survival (OS) than those without (P = 0.0158 and P = 0.000394, respectively). irAE severity did not significantly influence PFS or OS. The objective response rate was higher in patients with irAEs than those without (50.0% versus 0.0%, P = 0.0549). Multivariate analysis identified irAE occurrence as an independent factor for PFS (hazard ratio = 0.2084, P = 0.01383) and OS (hazard ratio = 0.0857, P = 0.001588). Interstitial lung disease was inferior to other irAE profiles for both PFS and OS. In conclusion, advanced NSCLC patients experiencing irAEs demonstrated superior clinical outcomes with nivolumab plus ipilimumab-based therapy, though interstitial lung disease may be less linked with PFS and OS than other irAE profiles.
A heart derived-soluble factor which controls kidney and cardiovascular function after acute cardiorenal syndrome
Authors: Hutchens Michael , Funahashi Yoshio , Hebert Jessica , Munhall Adam , Burfeind Kevin , Nguyen Elizabeth , Groat Tahnee , Nickerson Megan , Eiwaz Mahaba , Andeen Nicole , Yanagita Motoko , Gurley Susan 
Published: January 2024

Abstract

Heart and kidney are bi-directionally interacting organs. Because heart and kidney disease are amongst the most common human diseases, investigating disease-causing interactions is important. Here, we identified a new heart-derived endocrine mediator of kidney function, cardiac cysteine-and-glycine-rich protein 3 (CSRP3). We determined CSRP3's stimulus for release from the heart, plasma transit, and kidney disease-causing mechanism. We found that cardiac CSRP3 was upregulated after cardiac injury (modeled using cardiac arrest and cardiopulmonary resuscitation in the mouse), and released into the systemic circulation, subsequently undergoing megalin-dependent endocytosis in the renal proximal tubule and changing kidney cell phenotype. Administration of CSRP3 to mice experiencing focal kidney injury reproduced the kidney phenotype observed in cardiac arrest-exposed mice. Genetic deletion of cardiac CSRP3 or renal megalin ameliorated cardiac injury-induced chronic kidney injury. Lastly, pharmacologic megalin inhibition ameliorated CSRP3-mediated chronic renal injury. We describe the role of cardiac CSRP3 in a heart-kidney interaction which directs specific renal dysfunction and renovascular remodeling after injury. We describe a novel mechanism of the intricate coupling of heart and kidney which determines renal function. These investigations may eventually lead to novel therapy for heart-induced kidney disease.
KU60019 induced ATM blockage regulates GPR91/has-miR-576-3p to inhibit ovarian cancer progression
Authors: Zhou Yangyang , Guo Xiaolei , Dang Rongjing , Cong Lin , Zhao Xin 
Published: January 2024

Abstract
Ataxia telangiectasia mutated (ATM) protein play a key role in the DNA damage response and sustain genomic stability, targeting which has been widely studied in different types of cancer as a potential therapeutic strategy for antitumor therapies. However, the mechanism of targeting ATM in ovarian cancer has not been fully elaborated. In the current study, we explore the influence of GPR91 on ovarian cancer cells in the context of ATM blockage in vitro. We identified that GPR91 might be a potential target of miR-576-3p in ovarian cancer cells upon KU60019 treatment. KU60019 induced cell apoptosis by downregulating GPR91 level. Inhibition of miR-576-3p reversed KU60019 induced cell apoptosis by upregulating GPR91 in vitro. Our results revealed cellular and molecular pathways in KU60019 induced cell death as well as identified a novel potential target for antitumor research.
Empirical formula model and process parameter optimization of two-dimensional ultrasonic assisted grinding force based on 2.5D-Cf/SiC fiber orientation
Authors: Wang Yashuai , Xin Bo , Li Jiangtao , Zhu Lida 
Published: January 2024

Abstract

Due to the anisotropic characteristic of carbon fiber-reinforced silicon carbide ceramics, the fiber orientation angle significantly affects the grinding force. Therefore, it is important to study the influence rule of different fiber orientations on the grinding force of 2.5D-Cf/SiC composites. To study the comprehensive influence of machine tool parameters and the anisotropy of carbon fiber reinforced ceramic matrix composites on the grinding force, two-dimensional ultrasonic plane grinding was studied by orthogonal test and single factor experiment. Based on the multi-exponential fitting analysis method of multiple linear regression equation, the empirical equations of power exponential grinding force prediction model of 2D ultrasonic assisted grinding and conventional grinding 2.5D-Cf/SiC composites at 0°, 45°, 90° fiber orientation and considering fiber orientation and ultrasonic amplitude were established respectively. To verify the empirical formula model in predicting the grinding force of 2.5D-Cf/SiC composites under various fiber orientation angles, the regression equation and regression coefficient of the model were examined. The influence of 2.5D-Cf/SiC grinding parameters on the grinding force was analyzed. The parameters of the grinding force model were optimized based on range analysis and variance analysis, and the optimal process parameter combination was obtained. The results show that the grinding force is negatively correlated with the linear speed, and positively correlated with the feed speed and grinding depth within the range of experimental parameters. The maximum reduction of the normal grinding force is 29.78% when the line speed is 10.48m/s, the feed speed is 100 mm/min, the grinding depth is 50µm, and along the 45° fiber direction. The optimal grinding parameter combination is a line speed of 23.60m/s, feed speed of 5mm/min, and grinding depth of 10µm along the 0° fiber orientation.