bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silencing of secreted phosphoprotein 1 attenuates sciatic nerve injury‐induced neuropathic pain: Regulating extracellular signal‐regulated kinase and neuroinflammatory signaling pathways
Authors: Xie Haiyu , Lu Feng , Li Xiaoling , Wang Enfu , Mo Jiao , Liang Weidong 
Published: February 2024

AbstractBackgroundNeuropathic pain (NP) is a chronic pathological pain that affects the quality of life and is a huge medical burden for affected patients. In this study, we aimed to explore the effects of secreted phosphoprotein 1 (SPP1) on NP.MethodsWe established a chronic constriction injury (CCI) rat model, knocked down SPP1 via an intrathecal injection, and/or activated the extracellular signal‐regulated kinase (ERK) pathway with insulin‐like growth factor 1 (IGF‐1) treatment. Pain behaviors, including paw withdrawal threshold (PWT), paw withdrawal latency (PWL), lifting number, and frequency, were assessed. After sacrificing rats, the L4‐L5 dorsal root ganglion was collected. Then, SPP1 levels were determined using quantitative polymerase chain reaction (qPCR) and western blot analysis. The levels of interleukin (IL)‐1β, tumor necrosis factor (TNF)‐α, IL‐6, IL‐10, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)‐β were determined using qPCR and enzyme‐linked immunosorbent assay. The levels of ERK pathway factors were determined via western blot analysis.ResultsWe found that CCI decreased PWT and PWL, increased the lifting number and frequency, and upregulated SPP1 levels. The loss of SPP1 reversed these CCI‐induced effects. Additionally, CCI upregulated IL‐1β, TNF‐α, IL‐6, EGF, and VEGF levels, downregulated TGF‐β levels, and activated the ERK pathway, while silencing of SPP1 abrogated these CCI‐induced effects. Moreover, IGF‐1 treatment reversed the effects of SPP1 loss.ConclusionsThe data indicate that silencing SPP1 attenuates NP via inactivation of the ERK pathway, suggesting that SPP1 may be a promising target for NP treatment.
Timing of initial symptom onset during milk and wheat challenges: A retrospective study
Authors: Yanagida Noriyuki , Minoura Takanori , Sato Sakura , Takahashi Kyohei , Nagakura Ken‐ichi , Ogura Kiyotake , Itonaga Takaaki , Miura Yoko , Fusayasu Naoko , Ebisawa Motohiro 
Published: February 2024

AbstractBackgroundAllergic reactions to milk appear sooner than those to hen's eggs, irrespective of the total dose of the oral food challenges (OFCs) and type of matrices. The reported median times for the first symptom occurrence are 20–30 min with milk and 50–60 min with eggs. However, allergic reactions due to wheat have not yet been fully investigated.MethodsThis study retrospectively collected data from OFC for milk and wheat conducted at Sagamihara National Hospital and Sendai Medical Center from 2009 to 2023. The time from the start of the OFC to the onset of symptoms was compared between children with cow's milk and wheat allergy.ResultsTwenty‐five and 13 children reacted to single‐dose OFCs with milk products equivalent to 25 mL of raw cow's milk or 15 g of udon noodles, respectively. The median ages of patients with positive challenges were 1.4 and 2.8 years for milk and wheat, respectively, and the median times for the first symptom occurrence were 20 min and 53 min, respectively (p = .006).ConclusionThis multicenter study was the first to examine the time of symptom appearance during single‐medium‐dose milk and wheat challenges. Allergic reactions to wheat appear later than those for milk during OFC. For multiadministration OFC for wheat, the dosing interval should be longer than 60 min. Our findings can help improve the safety of OFCs.
An ecologically informed transdisciplinary prevention model for Black and Latine family wellbeing
Authors: Lozada Fantasy T. , Wheeler Naomi J. , Green McKenzie N. , Castro Andrene J. , Gómez Rachel F. , Gutierrez Daniel 
Published: February 2024

AbstractGiven noted racial disparities in mental health and wellbeing, Black and Latine families are often the focus of prevention and intervention efforts. These efforts are traditionally embedded in deficit perspectives about these communities, ignoring their cultural wealth and collective agency. Yet increasing recognition of the interconnected systems and social determinants that lead to racial disparities and negative outcomes among Black and Latine populations requires counselors and other practitioners to broaden their conceptions of prevention and engage in collaboration to develop more effective and comprehensive prevention efforts. In the current paper, we provide an ecologically informed transdisciplinary model of family empowerment, prevention, and wellbeing with Black and Latine families. We apply this model to counseling practice as a potential roadmap for future counseling prevention work with Black and Latine families.
内頸動脈海綿静脈洞瘻のプラチナコイル塞栓術後に脳膿瘍を合併したLemierre症候群の1例(Lemierre syndrome with brain abscess following platinum coil embolization for internal carotid artery cavernous sinus fistula: A case report)
Authors: 裕介 清水 , 勇希 持田 , 良平 西沢 , 賢彦 海田 , 芳裕 山口 
Published: February 2024

要旨Lemierre症候群は口腔咽頭領域の感染症を契機として内頸静脈の血栓性静脈炎と遠隔臓器感染を起こす，抗菌薬の発展とともに激減した症候群である。今回我々は，内頸動脈海綿静脈洞瘻のコイル塞栓術後に歯周病が波及し脳膿瘍と肝膿瘍を合併したLemierre症候群の１例を経験した。症例は60歳代の男性。外傷性内頸動脈海綿静脈洞瘻に対する経動静脈プラチナコイル塞栓術の１か月後に発熱と意識障害を主訴に救急搬送された。CTにて脳膿瘍と肝膿瘍を認めたため，それぞれ穿頭ドレナージと経皮経肝ドレナージを施行した。血液培養検査からFusobacterium naviformeが検出され，歯周炎と内頸静脈内の血栓も確認できたことからLemierre症候群と診断した。脳膿瘍は一度縮小傾向であったが再度増大し膿瘍が脳室穿破したため内視鏡的膿瘍除去術を施行し，その後は抗菌薬加療で膿瘍再増大を認めず，入院79日目にリハビリ転院となった。Lemierre症候群による脳膿瘍形成は稀であるが，頭蓋内病変に対するプラチナコイル塞栓後の脳膿瘍形成も同様に稀である。コイル術後の膿瘍形成の場合には，Lemierre症候群の可能性も考慮し早期に感染巣の全身検索を行うことが肝要である。
ツツガムシ病による敗血症性ショック, 血球貪食症候群に対し, ポリミキシンB固定化カラムによる直接血液灌流法, 血漿交換などの集学的治療を行った1例(A case of septic shock, hemophagocytic syndrome due to scrub typhus treated with polymyxin B immobilized fiber column direct hemoperfusion, plasma exchange)
Authors: 真也 坂戸 , 太 永嶋 , 知也 松田 , 元博 菊川 , 修 藤崎 , 保 後藤 , 誠人 小林 
Published: February 2024

要旨症例は72歳の女性。発熱，体幹部紅斑と全身倦怠感を主訴に救急搬送され，原因不明の敗血症およびDICとしてICUに入院した。入院時のSOFA scoreは14点，APACHE II scoreは28点であった。入院後，虫刺症を疑う痂皮のpolymerase chain reaction（PCR）検査でツツガムシ病と確定診断した。入院後，重篤な敗血症性ショック状態となり，polymyxin B immobilized fiber column direct hemoperfusion（PMX–DHP）を導入した。また，血球貪食症候群（hemophagocytic syndrome: HPS）を合併し，ステロイドパルス療法，血漿交換（plasma exchange: PE）を施行した。これらの集学的治療により，循環動態，SOFA score，DIC scoreは改善傾向を示し，フェリチン，LDHといったHPSの治療マーカーも改善した。その後，徐々に全身状態は良好となり，49病日に転院した。ツツガムシ病は時に重篤化する。敗血症性ショック，ARDS，HPSを呈した場合，時期を逸さないPMX–DHP，PEといった集学的な治療が有効である可能性がある。
Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta‐analysis
Authors: Keating Niamh , Cevik Jevan , Hopkins David , Lippey Jocelyn 
Published: February 2024

AbstractPreviously reported upgrade rates for benign breast intraductal papilloma (IDP) are widely variable. However, many previous studies have failed to consider radiologic‐pathologic discordance of lesions. This review aims to synthesize malignant upgrade data for benign, concordant IDP at surgical excision. Thirteen studies were included in our meta‐analysis. The pooled estimate for percentage underestimation of carcinoma was 1.4% (95% CI: 0.8%−2.0%). We conclude that these lesions can be safely managed by active surveillance.
Oxidation behavior of lightweight Al2NbTi3V2Zr high entropy alloy at 1000°C
Authors: Tan Xinrong , Zhi Qian , Pei Rong , Chen Yuhua , Xiong Wenwen , Xie Wen , Chen Yuqiang , Liu Yang 
Published: February 2024

AbstractLightweight high entropy alloy (LWHEA) has great potential in aeroengine hot component applications. Anticorrosion property of LWHEA at high temperatures is one of the key determining factors. In this study, an LWHEA containing Al, Nb, Ti, V, and Zr elements with a molar ratio of 2: 1: 3: 2: 1 was designed and prepared by low energy (LE) and high energy (HE) mechanical milling followed by vacuum hot pressing. The sintered LE alloy consisted of a simple cubic matrix and α intermetallic while the BCC matrix along with α and β intermetallic phases were observed in HE alloy. The oxidation of LE and HE at 1000°C for 48 h was mainly concentrated on α and β phases, and the resultant oxides were ZrO2 and TiO2. Weight gain curve of HE sample within oxidation time of 48 h followed the parabolic law while a two‐stage parabola was found in LE bulk. The steady‐state oxidation of α precipitate was dominant within 12 h and showed a preferential oxidation mode. High temperature induced simple cubic matrix to stable BCC phase transformation and thus LE alloy with longer oxidation time and HE exhibited a similar uniform oxidation. The oxidation rate of the alloy is related to the content of α and β phases.
Regulating unproductive contract adaptation: A payment deduction mechanism
Authors: Zhong Wenqin , Ren Ligang , Wang Mengyi 
Published: February 2024

AbstractTo the best of our knowledge, our paper offers a first attempt to uncover a payment deduction mechanism for regulating unproductive contract adaptation. Our model uncovers that the payment deduction mechanism can expropriate the ex post unproductive profit of a contractor. Using the data from California Department of Transportation, we confirm the positive effect of ex post payment deduction on ex post unproductive profit. Our estimates are robust to different estimation methods with different types of standard errors and the potential endogeneity bias. The payment deduction mechanism offers general applications to constrain ineffective contract implementation in the infrastructure industry.
Design of multiband frequency reconfigurable antenna with switchable polarization states
Authors: Vinayagam Kanniyappan , Natarajan Rajesh 
Published: February 2024

AbstractThis paper presents the design of multiband frequency reconfigurable patch antenna with switchable radiation pattern and polarization states. The antenna design is based on a circular patch radiator with a pair of metallic strips placed on diametrically opposite sides of it. Circular polarization (CP) from the antenna is excited by etching a pair of slots with a coaxial feed. When the diodes are OFF, the antenna resonates at 4.2, 6.6 GHz, (C band) and 8.07 GHz (X band) and the main beam is located at 0⁰ with CP at X band. The resonance at 4.2 and 8.5 GHz are observed when one of the diode is ON. The main beam at X band is being shifted from −30⁰ to 0⁰ and +30⁰ in the elevation plane during the change in operating modes. Peak gain of the antenna is 6 dBi in all the operating modes.
Method for solving state‐path constrained optimal control problems using adaptive Radau collocation
Authors: Byczkowski Cale A. , Rao Anil V. 
Published: February 2024

AbstractA new method is developed for accurately approximating the solution to state‐variable inequality path constrained optimal control problems using a multiple‐domain adaptive Legendre–Gauss–Radau collocation method. The method consists of the following parts. First, a structure detection method is developed to estimate switch times in the activation and deactivation of state‐variable inequality path constraints. Second, using the detected structure, the domain is partitioned into multiple‐domains where each domain corresponds to either a constrained or an unconstrained segment. Furthermore, additional decision variables are introduced in the multiple‐domain formulation, where these additional decision variables represent the switch times of the detected active state‐variable inequality path constraints. Within a constrained domain, the path constraint is differentiated with respect to the independent variable until the control appears explicitly, and this derivative is set to zero along the constrained arc while all preceding derivatives are set to zero at the start of the constrained arc. The time derivatives of the active state‐variable inequality path constraints are computed using automatic differentiation and the properties of the chain rule. The method is demonstrated on two problems, the first being a benchmark optimal control problem which has a known analytical solution and the second being a challenging problem from the field of aerospace engineering in which there is no known analytical solution. When compared against previously developed adaptive Legendre–Gauss–Radau methods, the results show that the method developed in this paper is capable of computing accurate solutions to problems whose solution contain active state‐variable inequality path constraints.
Electrical properties of elastomer‐based composites reinforced with carbon nanotubes—A review
Authors: Aït Hocine Nourredine , Miranda Catalina , Nauman Saad , Langlet André 
Published: February 2024

AbstractEven though carbon nanotubes offer an excellent solution for the design of strain sensors, their widespread commercial utilization has been hampered by the unavailability of design rules, inconsistencies in their macro‐scale properties, and lack of understanding of the effects of various parameters on their characteristics. Nevertheless, many researches have been carried out to characterize elastomeric nanocomposites filled with carbon nanotubes in order to optimize their properties such as electrical conductivity and strain sensitivity range. This article reviews the effect of different parameters on the electrical properties of such nanocomposites, followed by the analysis of performances of elastomer strain sensors.
Biochemical and patient factors as predictors for multiple surgeries in diabetic foot disease
Authors: Amarasena Danuksha K , Bilal Ahmad , Elkhidir Ibrahim H , Flatman Michael , Pillai Anand 
Published: February 2024

AbstractDiabetic foot disease (DFD) bestows a huge surgical burden on patients and health care systems worldwide. Medical and surgical management centres around limb preservation and maintaining patient mobility. Despite vast experience in managing DFD, little is understood about the surgical prognosis of a patient presenting for their first DFD procedure.We evaluated for predictive factors, observable at a patient's first presentation for a surgical procedure on their diabetic foot, which may indicate an increased likelihood of requiring similar procedures in the future.Method: Our study included 70 patients with diabetes mellitus who underwent surgery on their diabetic foot. These patients were split into cohorts. Cohort 1 received only one surgery on their diabetic foot; Cohort 2 received multiple surgeries on their diabetic foot. Statistical analysis was conducted looking at various parameters between the cohorts to assess for any significant differences at the time of first surgery.Results: On Mann‐Whitney U test, there was a significant difference in C‐reactive protein (CRP) between patients who had a single surgery and those receiving multiple surgeries (p=0.009). A binomial logistic regression model found CRP to be a significant predictor of whether a patient will undergo one surgery or multiple surgeries (Exp[B] 0.988, 95% CI 0.978–0.998). On analysis of the ROC curve, 84mg/L was the best cut‐off for CRP in predicting number of surgeries.Clinical relevance: These predictive factors could highlight patients who are ‘at risk’ for needing further procedures, so they can be managed with more intense surveillance and follow‐up. Copyright © 2024 John Wiley & Sons.
Enhancing academic resilience through mindfulness‐based practices in the schools: A study on vocational high school students
Authors: Erdemir Nihan , Karanfil Ferhat , Şengül Raziye 
Published: February 2024

AbstractIn recent years, the positive correlation between mindfulness and resilience has gained visible importance. For this purpose, this study aims to increase the academic resilience and mindfulness level of vocational high school students with a low socioeconomic background, who often have lower resilience toward learning English as a foreign language (EFL) in Türkiye. The study adopted an experimental research design. Before and after an eight‐session mindfulness‐based intervention, the Academic Resilience Scale and Mindful Attention Awareness Scale‐Adolescent measured the levels of mindfulness awareness and academic resilience. The pretest and posttest results in control and experimental groups were analyzed in SPSS, and independent samples t‐test and analysis of covariance were conducted for data analysis. Focus‐group interviews explored possible attributions toward mindfulness awareness and academic resilience, using MAXQDA. The results revealed that there is a significant difference between the groups in terms of academic resilience, but there is no significant difference in the case of mindfulness. On the other hand, most students reported that their academic resilience increased, and they had positive attitudes toward mindfulness‐based practices. However, it was observed that their classmates' distractive and biased behaviors in the classroom setting mostly resulted in a lapse in their mindfulness.
Academic procrastination and fear of failure: The role of irrational/rational academic beliefs
Authors: Balkis Murat , Duru Sibel , Duru Erdinç 
Published: February 2024

AbstractExtant research has consistently demonstrated that both irrational and rational beliefs contribute to the occurrence and persistence of procrastination. Most of these studies have focused on the role of general irrational and rational beliefs, without addressing domain‐specific beliefs that may influence academic procrastination. This cross‐sectional study aims to fill that gap by investigating the relationship between irrational/rational academic beliefs, fear of failure, and academic procrastination in a sample of undergraduate students (N = 354). The current findings suggest that irrational academic beliefs are indirectly associated with academic procrastination through fear of failure. Furthermore, the positive relationship between irrational academic beliefs and academic procrastination via fear of failure differs based on the level of rational academic beliefs. These findings suggest that interventions designed to improve domain‐specific rational academic beliefs and reduce fear of failure may help prevent or reduce academic procrastination, especially among undergraduates with high levels of irrational beliefs.
From pixels to riverscapes: How remote sensing and geospatial tools can prioritize riverscape restoration at multiple scales
Authors: Glassic Hayley C. , McGwire Kenneth C. , Macfarlane William W. , Rasmussen Cashe , Bouwes Nicolaas , Wheaton Joseph M. , Al‐Chokhachy Robert 
Published: February 2024

AbstractPrioritizing restoration opportunities effectively across entire riverscape networks (i.e., riverine landscape including floodplain and stream channel networks) can be difficult when relying on in‐channel, reach‐scale monitoring data, or watershed‐level summaries that fail to capture riverscape heterogeneity and the information necessary to implement restoration actions. Leveraging remote sensing and geospatial tools to develop spatially continuous information across nested hierarchical scales may support increased understanding of local riverscape reaches in their broader network context. Using riparian (vegetation) and geomorphic (elevation) indicators to assess status of riverscape health, along with a measure of restoration capacity (valley bottom area), could be adapted to fit specific management goals related to riverscape restoration. Frameworks using remotely sensed vegetation and elevation data to prioritize restoration continuously across riverscapes at restoration‐relevant, reach‐scales may uphold the ecosystem services provided by riverscapes. By incorporating local knowledge and identifying caveats for using these datasets, continuous inferences can be applied at network scales (watershed to regional extent and reach‐scale resolution) to prioritize restoration over a wide variety of ecoregions.This article is categorized under:
Water and Life > Conservation, Management, and Awareness
Water and Life > Methods
Water and Life > Stresses and Pressures on Ecosystems
Fractures and other chest wall abnormalities after thoracotomy for esophageal cancer: A retrospective cohort study
Authors: Van Wijck Suzanne F. M. , Barza Athiná , Vermeulen Jefrey , Eyck Ben M. , Van der Wilk Berend J. , Van der Harst Erwin , Verhofstad Michael H. J. , Lagarde Sjoerd M. , Van Lieshout Esther M. M. , Wijffels Mathieu M. E. 
Published: February 2024

AbstractBackgroundChest pain following a thoracotomy for esophageal cancer is frequently reported but poorly understood. This study aimed to (1) determine the prevalence of thoracotomy‐related thoracic fractures on postoperative imaging and (2) compare complications, long‐term pain, and quality of life in patients with versus without these fractures.MethodsThis retrospective cohort study enrolled patients with esophageal cancer who underwent a thoracotomy between 2010 and 2020 with pre‐ and postoperative CTs (<1 and/or >6 months). Disease‐free patients were invited for questionnaires on pain and quality of life.ResultsOf a total of 366 patients, thoracotomy‐related rib fractures were seen in 144 (39%) and thoracic transverse process fractures in 4 (2%) patients. Patients with thoracic fractures more often developed complications (89% vs. 74%, p = 0.002), especially pneumonia (51% vs. 39%, p = 0.032). Questionnaires were completed by 77 after a median of 41 (P25–P75 28–91) months. Long‐term pain was frequently (63%) reported but was not associated with thoracic fractures (p = 0.637), and neither were quality of life scores.ConclusionsThoracic fractures are prevalent in patients following a thoracotomy for esophageal cancer. These thoracic fractures were associated with an increased risk of postoperative complications, especially pneumonia, but an association with long‐term pain or reduced quality of life was not confirmed.
Konzepte zur Analyse von Performativität in der Kulturproduktion
Authors: Schwegler Guy 
Published: February 2024

ZusammenfassungIn diesem Kapitel werden Konzepte vorgestellt, mit denen die Performativität kultur- und sozialwissenschaftlicher Theorien in einem bestimmten gesellschaftlichen Teilbereich analysiert werden kann: der Kulturproduktion. Zunächst handelt es sich um verschiedene Konzeptualisierungen von Lebensstilen. Die Ergebnisse der Kulturproduktion, die durch die Theorien realisiert werden, können einerseits als Distinktions- und andererseits als Reflexionsressourcen erfasst werden. Darüber hinaus ermöglichen die Feldtheorie und die Konzeptualisierung sozialer Welten die Berücksichtigung unterschiedlicher Interessen im Kontext einer Produktion. Schließlich wird in diesem Kapitel die sogenannte Mediation erläutert, um eine Ontologie der Kulturproduktion genauer zu betrachten.
Methodologien und Methoden für die Analyse von Performativität
Authors: Schwegler Guy 
Published: February 2024

ZusammenfassungIn diesem Kapitel wird erläutert, wie sich die methodologischen Grundüberlegungen der Arbeit in das konkrete Vorgehen einer qualitativen Studie umsetzen ließen. Erstere Überlegungen stehen insbesondere im Zusammenhang mit der Herausforderung einer Sozio-Epistemologie: Wie kann gemeinsam mit theoretisch informierten Akteur*innen Wissen über die Performativität der Kultur- und Sozialwissenschaften produziert werden? Unterschiedliche und zum Teil widersprüchliche Antworten auf diese Frage werden dann integriert, indem einerseits auf eine Vermittlung der beiden Megaparadigmen Pragmatismus und Strukturalismus verwiesen wird. Andererseits wird verdeutlicht, wie mit dem Ansatz der Grounded Theory und der daraus abgeleiteten Situationsanalyse bereits ein adäquates Vorgehen ermöglicht werden kann. Abschließend werden die weiteren Ergänzungen erläutert, welche konkret die empirische Arbeit angeleitet haben.