bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of musculoskeletal disorders among healthcare professionals in Africa: A systematic review and meta-analysis
Authors: Aremu Abdulmujeeb Babatunde , Afolabi Ismail Bamidele , Odongo Owino Alfred , Shehzad Sheeraz , Khan Khalid S. 
Published: October 2023

Abstract

Background
Musculoskeletal disorders (MSDs) decrease productivity. The objective of this systematic review was to estimate the regional prevalence of MSD among healthcare professionals in Africa.
Methods
After prospective registration (PROSPERO CRD42023455517), a literature search was conducted in PubMed, Science Direct and Google Scholar in August 2023. Observational studies that reported the prevalence of MSDs among healthcare professionals were included. Studies were assessed for risk of bias in duplicate. The data were pooled using random effects models to estimate the prevalence of MSD with 95% confidence interval (CI) and I2 statistic captured heterogeneity.
Results
From 17,322 citations, 18 studies (4486 participants) were included. Of these, 8 (44%) were high-quality studies and 10 (56%) medium-quality. The overall pooled prevalence of MSDs was 70.8% (95% CI 61.9–78.961.9–78.9, I2 97.5%). The regional prevalence of MSDs in East Africa was 68.7% (95% CI 58.4–78.1, I2 94.9%; 7 studies, 1885 participants); West Africa 72.0% (95% CI 53.2–87.4, I2 95.8%; 4 studies, 604 participants); South Africa 61.6% (95% CI 53.0–70.0, I2 77.5%; 3 studies, 681 participants); and, North Africa 79.6% (95% CI 50.6–97.5, I2 99.2%; 4 studies, 1316 participants). The prevalence of MSDs among different professional groupings was: Physiotherapists 89.8% (95% CI 74.3–98.6, I2 97.4%; 4 studies, 1061 participants); Nurses 65.3% (95% CI 55.2–74.8, I2 65.3%; 8 studies, 2239 participants); Dentists 67.8% (95% CI 58.2–76.7, I2 87.5%; 4 studies, 827 participants); and, Medical laboratory staff 52.8% (95% CI 43.6–61.9, I2 52.8%; 2 studies, 359 participants).
Conclusion
Pooling studies of mixed quality revealed a high prevalence of MSD among healthcare professionals in Africa. This meta-analysis will help in regional occupational healthcare policy and prevention programs among various healthcare professions.
Analysis of different expression RBP genes in mouse microglia cell from the brains of mice 72h after subarachnoid hemorrhage or sham operation
Authors: Pan Xinyi , Ouyang Hengyang , Xiao Xue , Zhou Xiaobing , Lai Lingfeng 
Published: October 2023

Abstract

Background
The prognosis of brain injury caused by subarachnoid hemorrhage (SAH) is poor. Previous studies showed that abnormal function of RBPs might be involved in brain injury, neuroinflammation and further affect microglia homeostasis. However, no studies have systematically analyzed the genome-wide abnormal expression of RBPs genes in microglia during SAH.
Methods
RNA-seq data of microglia from the SAH mouse group (SAH) and control sham-operated mouse group (sham) were downloaded from the GEO database in GSE167957, including four samples from the sham group and four samples from the SAH group for subsequent analysis. Further analysis of differentially expressed RBPs and differential ASEs between the SAH and sham groups revealed the potential mechanism of the role of aberrantly expressed RBPs in microglia during brain injury in SAH.
Results
ASEs and co-expression analyses of differentially expressed RBPs and differential ASEs were carried out in microglia in terms of gene expression. GO and KEGG functional enrichment analysis showed that aberrantly expressed RBPs such as Mcm7, Mtdh, SRSF3, and Hnrnpa2b1 may affect and regulate downstream Csnk1d, Uckl1 and other protein phosphorylation-related genes by alterative splicing.
Conclusion
RBPs were aberrantly expressed in microglia during the development of brain injury secondary to SAH, regulating alterative splicing of downstream genes and influencing the progression of SAH brain injury in this study. This implies that RBPs are important for the identification of new therapeutic targets for brain injury after SAH.
The Sun’s Large-Scale Flows I: Measurements of Differential Rotation &amp; Torsional Oscillation Solar Physics
Authors: Mahajan Sushant S. , Upton Lisa A. , Antia H. M. , Basu Sarbani , DeRosa Marc L. , Webber Shea A. Hess , Hoeksema J. Todd , Jain Kiran , Komm Rudolf W. , Larson Tim , Nagovitsyn Yury A. , Pevtsov Alexei A. , Roudier Thierry , Tripathy Sushanta C. , Ulrich Roger K. , Zhao Junwei 
Published: October 2023

Abstract
We have developed a comprehensive catalog of the variable differential rotation measured near the solar photosphere. This catalog includes measurements of these flows obtained using several techniques: direct Doppler, granule tracking, magnetic pattern tracking, global helioseismology as well as both time-distance and ring-diagram methods of local helioseismology. We highlight historical differential rotation measurements to provide context and thereafter provide a detailed comparison of the MDI-HMI-GONG-Mt. Wilson overlap period (April 2010-Jan 2011) and investigate the differences between velocities obtained from different techniques and attempt to explain discrepancies. A comparison of the rotation rate obtained by magnetic pattern tracking with the rotation rates obtained using local and global helioseismic techniques shows that magnetic pattern tracking measurements correspond to helioseismic flows located at a depth of 25 to 28 Mm. In addition, we show the torsional oscillation from sunspot cycles 23 and 24 and discuss properties that are consistent across measurement techniques. We find that acceleration derived from torsional oscillation is a better indicator of long-term trends in torsional oscillation compared to the residual velocity magnitude. Finally, this analysis will pave the way toward nderstanding systematic effects associated with various flow measurement techniques and enable more accurate determination of the global patterns of flows and their regular and irregular variations.
A Multi-Site Phase I Trial of Veliparib with Standard Radiation and Temozolomide in Patients with Newly Diagnosed Glioblastoma Multiforme (GBM)
Authors: Kleinberg Lawrence , Ye Xiaobu , Supko Jeff , Stevens Glenn H.J. , Shu Hui-Kuo , Mikkelsen Tom , Lieberman Frank , Lesser Glenn , Lee Emerson , Grossman Stuart 
Published: October 2023

Abstract
Purpose
A multi-site Phase I trial was conducted to determine the safety, maximum tolerated dose, and pharmacokinetics (PK) of Veliparib, a Poly (ADP-ribose) polymerase [PARP] enzyme inhibitor, when administered with temozolomide (TMZ) alone and then with temozolomide and radiation (RT) in patients with newly diagnosed glioblastoma.
Methods
Given the potential for myelosuppression when a PARP inhibitor is combined with chemotherapy, the first 6 patients accrued were given Veliparib 10 mg bid and TMZ 75 mg/m2/d daily for six weeks. If this was well tolerated, the same doses of Veliparib and TMZ would be tested along with standard radiation with plans to dose escalate the Veliparib in subsequent patient cohorts. Once a maximal tolerated dose was determined, a 78 patient phase II study was planned. Peripheral blood pharmacokinetics were assessed.
Results
Twenty-four patients were enrolled. In the first 6 patients who received 6 weeks of TMZ with Veliparib only one dose limiting toxicity (DLT) occurred. The next 12 patients received 6 weeks of RT + TMZ + veliparib and 4/12 (33%) had dose limiting hematologic toxicities. As a result, Veliparib was reduced by 50% to 10 mg BID every other week, but again 3/3 patients had dose limiting hematologic toxicities. The trial was then terminated. The mean clearance (± SD) CL/F of Veliparib for the initial dose (27.0 ± 9.0 L/h, n = 16) and at steady-state for 10 mg BID (23.5 ± 10.4 L/h, n = 18) were similar. Accumulation for BID dosing was 56% (± 33%).
Conclusions
Although Veliparib 10 mg BID administered with TMZ 75 mg/m2 for six weeks was well tolerated, when this regimen was combined with standard partial brain irradiation it was severely myelosuppressive even when the dose was reduced by 50%. This study again highlights the potential of localized cranial radiotherapy to significantly increase hematologic toxicity of marginally myelosuppressive systemic therapies.
Analysis of the genomic sequences and metabolites of Bacillus velezensis YA215 with antimicrobial activity
Authors: Yu FuTian , Shen YuanYuan , Chen ShangLi , Fan HeLiang , Pang YiYang , Liu MingYuan , Peng JingJing , Pei XiaoDong , Liu XiaoLing 
Published: October 2023

Abstract
Discovering more novel antimicrobial compounds has become an keen research problem. In this study, YA215 genome was sequenced by the Illumina HiSeq + PacBio sequencing platform. Genome assembly was performed by Unicycler software and the gene clusters responsible for secondary metabolite biosynthesis were predicted by antiSMASH. The genome comprised 3976514 bp and had a 46.56% G + C content. 3809 coding DNA sequences, 27 rRNAs, 86 tRNAs genes and 79 sRNA were predicted. Strain YA215 was re-identified as Bacillus velezensis based on ANI and OrthoANI analysis. In the COG database, 23 functional groups from 3090 annotations were predicted. In the GO database, 2654 annotations were predicted. 2486 KEGG annotations linked 41 metabolic pathways. Glycosyl transferases, polysaccharide lyases, auxiliary activities, glycoside hydrolases, carbohydrate esterases and carbohydrate-binding modules were predicted among the 127 annotations in the CAZy database. AntiSMASH analysis predicted that strain B. velezensis YA215 boasted 13 gene clusters involved in synthesis of antimicrobial secondary metabolites including surfactin, fengycin, macrolactin H, bacillaene, difficidin, bacillibactin, bacilysin, and plantazolicin. Three of the gene clusters (gene cluster 5, gene cluster 9 and gene cluster 10) have the potential to synthesize unknown compounds. The research findings have the potential to contribute significantly to the development of natural novel compounds with antimicrobial activity in B. velezensis YA215.
Kinetics and Modeling of Osmotic Dehydration of Plantain (Musa paradisiaca) using a Low- calorie Sugar
Authors: Lobe Elias Eyembe , Nde Divine Bup , Jean Sonchieu 
Published: October 2023

Abstract

The study was aimed at evaluating the influence of process variableon mass transfer parameters; water loss (WL) and solute gain (SG) on osmotic dehydration of plantain (Musa paradisiaca) in low calorie sugar solution. Fully matured unripe plantain fruits of the ´´False Horn´´ cultivar were peeled and sliced into thicknesses of 2.5, 5 and 10mm. The slices were immersed in the commercial low-calorie sugar solutionsof concentrations 12.5, 25 and 50% and varying sample /solution ratio (1:5, 1:10 and 1:20) at room temperature (27 ± 2). To investigate the effect of temperature, plantain slices of thickness 5mm were immersed in low calorie sugar solution of concentration 12.5 and sample/solution ratio 1:20 at temperatures 30, 40 and 50°C. The water WL and SG of the slices under the different experimental conditions were measured at various time intervals (10, 20, 40, 60, 80, 100, 120 and 140min). The kinetics of the osmotic dehydration was modeled using the Azuara, Peleg and Page models.Plantain slice of thickness 5mm, low-calorie sugar solution concentration of 50% at temperature 40°C, and a sample/solution ratio of 1:20 was judged best for osmotic treatment of plantains in low-calorie sugar solution.The Peleg model best described the dehydration kinetics with the highest R2(> 0.999) and the least RMSE.
Edge Manipulations for the Maximum Vertex-Weighted Bipartite b-matching
Authors: Auricchio Gennaro , Ma Qun , Zhang Jie 
Published: October 2023

Abstract

MDFS, and MAP – that, given an MVbM problem as input, return a b-matching. We weighted b-Matching (MVbM) problem on bipartite graphs(A∪T,E). The setAcomprises agents,whileTrepresents tasks. The set E, which connectsAandT, is the private information of either agents or tasks. In this framework, we investigate three mechanisms – MBFS, MDFS, and MAP– that, given an MVbM problem as input, return a b-matching. We examine scenarios in which either agents or tasks are strategic and report their adjacent edges to one of the three mechanisms. In both cases, we assume that the strategic entities are bounded by their statements: they can hide edges, but they cannot report edges that do not exist. First, we consider the case in which agents can manipulate. In this framework,MBFSand MDFSare optimal but not truthful. By characterizing the Nash Equilibria induced by MBFSand MDFS, we reveal that both mechanisms have a Price of Anarchy(PoA)and Price of Stability(PoS)of 2. These efficiency guarantees are tight; no deterministic mechanism can achieve a lowerPoAorPoS. In contrast, the third mechanism, MAP, is not optimal, but truthful and its approximation ratio is 2. We demonstrate that this ratio is optimal; no deterministic and truthful mechanism can outperform it. We then shift our focus to scenarios where tasks can exhibit strategic behaviour. In this case,MBFS,MDFS, and MAPall maintain truthfulness, making MBFS and MDFStruthful and optimal mechanisms. In conclusion, we investigate the manipulability of MBFS and MDFSthrough experiments on randomly generated graphs. We observe that (i) MBFSis less prone to be manipulated by the first agent than MDFS; (ii) MBFSis more manipulable on instances in which the total capacity of the agents is equal to the number of tasks; (iii) randomizing the agents’ order reduces the agents’ ability to manipulate MBFS.
The effect of tropicamide 0.5% versus tropicamide 1% on intraocular pressure in patients with diabetes mellitus: a randomized clinical trial
Authors: Sadr Navid Elmi , Mirsharif Seyyedeh Sedigheh , Lavvaf Samaneh , Hariri Ramyar 
Published: October 2023

Abstract

Objectives: To assess and compare the effects of tropicamide 0.5% and tropicamide 1% on intraocular pressure (IOP) and pupil diameter (PD) in patients with diabetes mellitus.
Methods: A total of 98 eyes of 98 diabetic patients were included in this double-masked randomized clinical trial. Patients were randomly assigned to receive either tropicamide 0.5% (49 eyes) or tropicamide 1% (49 eyes). IOP was measured by Goldmann applanation tonometry; PD was measured by Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany), before and 30 min after tropicamide administration.
Results: Mean PD change and IOP change was 2.99 ± 0.62 mm and 0.12 ± 1.71 mm Hg in tropicamide 0.5% group, and was 3.11 ± 0.55 mm and 0.25 ± 1.70 mm Hg in tropicamide 1% group, with no significant difference (P = 0.31, P = 0.72, respectively). No participants had IOP increase of 5 mm Hg or more.
Conclusion: The effect of tropicamide 0.5% and tropicamide 1% drops on IOP and PD was similar. Mydriasis with tropicamide did not result in significant IOP change.
Developing an Automated Analysis System of Lexical Richness for Chinese As a Second Language Text
Authors: Zhang Chao , Ma Rong 
Published: October 2023

Abstract

Lexical richness is an essential construct in second language writing research. The existing method to measure lexical richness in Chinese as a second language (CSL) research is inaccurate and time-consuming, which reduces the reliability and comparability of research conclusions and limits sample sizes. The present study develops a lexical richness automated analysis system for CSL text (i.e. the LRAAS) that can process CSL text documents in batches and produce fifteen main indices of lexical richness. The LRAAS has shown high reliability and accuracy in calculating the lexical richness of CSL text by comparing artificial and automated calculation results with different Chinese proficiency levels. Furthermore, the LRAAS will achieve greater accuracy as the lexicon and dynamic corpus training data expand. At present, the LRAAS is a reliable tool for CSL researchers analyzing learners’ lexical richness and has several potential applications in the field.
Mining-Business: Analysis of the Socio-Environmental Impacts of an Environmental Disaster in the City of Maceió, Brazil
Authors: Filho Walter Araujo Lima , Levino Natallya Almeida , Guanieri Patrícia 
Published: October 2023

Abstract

In mid-2018, several neighbourhoods in Maceió, Brazil were affected by soil subsidence in the region. Since then, unprecedented developments and consequences have been observed in the affected areas. Against this backdrop, the study aims to analyse the socio-environmental impacts suffered by the five neighbourhoods affected by subsidence from rock salt extraction in the municipality of Maceió. We collected secondary data from documents (Geological Survey studies, information made available by the Federal Public Prosecutor's Office, Compensation Plan, Terms of Agreement, Socio-urban Action Plan, Environmental Impact Study, Study of the economic impact of the disaster) to assess the socio-environmental impacts caused by the socio-environmental disaster. The results highlight the complexity of the effects, since they were observed from the perspective of the physical, biotic and anthropic environments. In addition, it is clear that these impacts were relevant and important from the specialists' point of view and when analysed quantitatively and qualitatively. The study also constated that it is pertinent to take measures to mitigate the impacts indicated as possible through integration between public authorities and the mining company. These results can be relevant for practitioners and policymakers involved in decisions related to mining operations.
Design, implementation and evaluation of e-learning program for common diseases to smartphone-based medical students: at a Developing University
Authors: niromand Elham , Mansoory Meysam Siyah , Ramezani Ghobad , Khazaei Mohammad Rasool 
Published: October 2023

Abstract

Objective Mobile-based educational software offers a wealth of resources that can foster the growth of learners and facilitate the creation of an interactive learning environment. This environment encourages both students and instructors to engage in exploration and the examination of various medical issues. The objective of this study is to design, implement, and evaluate an electronic educational program focused on common medical conditions, specifically tailored for medical students and accessible through mobile phones. Method The study was conducted following an action research approach, which comprised four key stages: needs assessment, application design, training, and evaluation. This research took place at the Kermanshah University of Medical Sciences' Medical School. In the needs assessment phase, a formal survey was distributed to the teaching faculty members, requesting them to identify diseases and medical issues of high importance for medical interns' education that were suitable for virtual teaching. Each faculty member was asked to prioritize a minimum of three and a maximum of seven cases. Subsequently, 10 faculty members from various departments completed the survey, leading to the identification of 47 common diseases after eliminating duplicates. These 47 cases were then presented to 30 medical interns, who were asked to select the 20 most significant cases. The 20 diseases with the highest statistical frequency were selected for further development due to resource constraints. The mobile application was developed for the Android platform using the Java programming language and the Android Studio development environment. To assess the application's effectiveness from the students' perspective, a questionnaire was designed, encompassing 25 questions across five domains: satisfaction, performance, learning, usability, and educational effectiveness. The questionnaire employed a Likert scale, with response options ranging from 'completely disagree' to 'completely agree,' scored from 1 to 5. One hundred medical interns and trainees were invited to participate in the evaluation, with 92 of them completing the questionnaires. Results The findings revealed a significant disparity in the average scores between students who underwent traditional teaching methods and those who engaged in mobile-based app-assisted education. This discrepancy was statistically significant across all three examined components. Conclusion Mobile-based learning represents a burgeoning educational approach with profound implications for healthcare education and the enhancement of patient care quality. The widespread integration of mobile phones into the educational framework offers a flexible teaching paradigm, fostering the potential for continuous lifelong learning.
Study of Anesthesia Agents Used for Ophthalmic Surgery
Authors: Fahed Aya mohammad nabeel , Jubran Wafaa Muafaq , Rekmani Najwa fajr 
Published: October 2023

Abstract

Background and Aim:
Selecting an anesthetic agent for ophthalmic surgery has crucial implications for the surgeon, anesthesiologist, and patient, this study explores the common classes of anesthesia used in ophthalmology and the influence of age, gender, duration of surgery, surgical and comorbid antecedents, and type of surgery on those techniques.
Methods and material:
A cross-sectional descriptive study, in Damascus Hospital between 1/6/2023 and 11/8/2023. 100 male and female patients were collected to be included in the study, according to certain inclusion and exclusion criteria, and several statistical methods were used to explain and clarify the results.
Results
We studied a group of valuable results and found that the average age of patients (54.61 ± 18.584) and the average age of the group of anesthesia patients (retrobulbar and sub conjunctival block) (63.41 ± 10.057 years) (P-value = 0.000), and according to gender (54% males, 46% females) and the ratio of the use of anesthesia (retrobulbar and sub conjunctival block) among males to females (38% / 26%) and general anesthesia (12% / 15%) (P-value = 0.391), and it was found that the average duration of surgery was (50.23 ± 22.811 minutes), the average duration of surgery for anesthesia patients (retrobulbar and sub conjunctival block) (45.16 ± 12.311 minutes) (P-value = 0.003), the percentage of surgery (elective/ emergency) (95% / 5%), most patients The paramedics were given general anesthesia (P-value = 0.007).
Conclusion
Anesthetizing the eye has rapidly evolved in recent years, supporting the safety, efficacy and comfort of ocular surgery. Since there are many viable options of anesthetics available for ophthalmic surgery, a robust understanding of the patients’ needs, the skill of the surgical team, and surgery-specific factors ought to be considered when creating an anesthetic plan for surgery.
Review of Sponge City implementation in China: performance and policy
Authors: Chikhi Faiza , Li Chuangcheng , Ji Qunfeng , Zhou Xilin 
Published: October 2023

Abstract
Urban flooding is a major problem for large cities around the world. Rapid urbanization in China has tremendously increased, resulting in more frequent incidences of urban flooding. In 2013, China launched a program of 30 pilot sponge cities (SPCs) to establish integrated urban stormwater management. However, today, after several years of implementation, some sponge cities still experience flooding. This study provides answers and solutions to these problems, by evaluating the overall performance of SPC in China from a systematic perspective considering the variable climatic conditions. This paper also highlights the limitations associated with implementing the current SPC. The adoption of overseas models, before adhering them to Chinese catchment properties, has generated significant uncertainty for simulation outputs and material provision challenges at various stages of the implementation process. Furthermore, hydrological connectivity between neighboring catchments has been neglected in most SPC projects. Developing local models based on local conditions and needs would address these issues and open new research windows for exploring more effective stormwater management initiatives. That includes the advancement of cost-effective evaluation studies, modern optimum efficiency design studies, and the analysis of groundwater contamination due to high infiltration rates and so on.