bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical, mineralogical and physical study of Late Iron Age ceramics from Nditam: Cameroon (West central Africa)
Authors: Zoila Luz Epossi Ntah , Giuseppe Cultrone 
Published: January 2024

Abstract
This paper studied Late Iron Age ceramic fragments from Nditam village (Centre Region, Cameroon), the technological features and deduced the type of the raw materials used to produce them by combining different analytical techniques based on X-ray fluorescence, powder X-ray diffraction, thermogravimetry, polarized optical microscopy, spectrophotometry and hydric tests. Macroscopic observations suggest the existence of three types of ceramics according to their colour, black, greyish and red, in the two opposite surfaces, outer (or external) and inner (internal). The chemistry indicates that non-calcareous clayey material was used for ceramic production. The correlation between mineralogy, petrography and the geology of the region suggests a local production of ceramics. Moreover, the chemistry of the samples confirms the existence of the three macroscopic groups and suggests the use of local raw materials for their production. From the mineralogical point of view, quartz, feldspar and mica (biotite and muscovite) were identified in all the samples, while kaolinite and amphibole were detected in some of them. The differences in the mineralogy may indicate some variations in the firing temperature, being lower in the ceramics containing kaolinite compared to the other samples. All the samples have similar water absorption behaviour. According to the colours of the ceramics, a prevalence of oxidising firing conditions was present in the kilns. However, partial reducing and short duration firing conditions were also possible. Comparative study with the mineralogy of ethnographic ceramics from southern Cameroon shows some similarities and suggests a continuity in the use of different local clay pits in this region over time.
Ethnic differentiation in the internal spatial configuration of vernacular dwellings in the multi-ethnic region in Xiangxi, China from the perspective of cultural diffusion
Authors: Ding Chuanbiao , Zhuo Xiaolan , Xiao Dawei 
Published: January 2024

Abstract
Understanding the cultural characteristics and evolution of traditional dwellings in the context of ethnic integration is of great significance for protecting the diversity of residential cultural heritage of ethnic minorities. This article compares the ethnic differences in the internal spatial configuration of vernacular dwellings in Xiangxi region, China, a typical multi-ethnic area where “line-shaped” dwellings are prevalent among the Miao, Dong, Yao, Tujia, and Han groups. This study found that the spatial sequence, ritual axis, importance of fireplace, spatial hierarchy, and privacy of bedrooms of each ethnic group's dwellings present a trend towards Han’s dwelling culture in the order of "Western Miao, Southern Dong, Northern Dong, Yao, Eastern Miao, Tujia". Based on the analysis of the lifestyles, ethnic customs, and historical development processes of ethnic minorities, this study identifies that the main reasons for the formation of the aforementioned sequence lie in the differences in the historical diffusion patterns and paths of Han culture in Xiangxi. This article analyses the ethnicity of minority residential culture in Xiangxi and its spatial configuration formation process, revealing the relationship between the spatial effect of Han cultural diffusion pattern and the spatial difference pattern of each ethnic group's vernacular dwelling space configuration, and expanding the connotation of "cultural genotypes" in multi-ethnic areas.
A diffusion probabilistic model for traditional Chinese landscape painting super-resolution
Authors: Lyu Qiongshuai , Zhao Na , Yang Yu , Gong Yuehong , Gao Jingli 
Published: January 2024

Abstract
Traditional Chinese landscape painting is prone to low-resolution image issues during the digital protection process. To reconstruct high-quality images from low-resolution landscape paintings, we propose a novel Chinese landscape painting generation diffusion probabilistic model (CLDiff), which is similar to the Langevin dynamic process, and realizes the transformation of the Gaussian distribution into the empirical data distribution through multiple iterative refinement steps. The proposed CLDiff can provide ink texture clear super-resolution predictions by gradually transforming the pure Gaussian noise into a super-resolution landscape painting condition on a low-resolution input through a parameterized Markov Chain. Moreover, by introducing an attention module with an energy function into the U-Net architecture, we turn the denoising diffusion probabilistic model into a powerful generator. Experimental results show that CLDiff achieves better visual results and highly competitive performance in traditional Chinese Landscape painting super-resolution tasks.
Facial reconstruction of a deformed skull from the Roman period of Juliopolis
Authors: Sertalp Evren , Moraes Cicero , Bütün Erge 
Published: January 2024

Abstract
The use of digital technologies in archaeological research has become considerably more widespread in recent years. While the earliest records of the use of electronic data in archaeology date from the 1950 and 1960s, the field has kept growing with the increasing interest in digital tools such as digital photography, three-dimensional imaging, GIS, virtual and artificial reality applications, CAD and facial reconstruction. Such digitization practices are used frequently for documenting, record keeping, and preserving and representing the data recovered from archaeological contexts, and are linked to other fields, such as cultural heritage studies and museology. Facial reconstruction is used to recreate the faces of individual from the past using their skeletal remains. It has been practiced for different reasons in the fields of forensics, anthropology, and archaeology. This study focuses on the facial reconstruction of a skull unearthed from Juliopolis. The reason for choosing this skull in this study is that it is the first and only known deformed skull dated to the Roman period in Anatolia. For the facial reconstruction application, authors created a 3D modelling of the skull by photogrammetry. Then, the missing parts of the skull are completed using the virtual donor library. The results are presented in different forms, as grayscale, in colour with eyes closed or open. Also, the type of deformation is demonstrated in the skull. This study adopts a digital process and is more strongly linked to data interpolation related to the external surface of the face. The prominent advantage of the methodology is being strongly supported by information obtained from computed tomography (CT) scans of living individuals, leaving a little room for the artistic issue in relation to the basic aspect resulting from the interpolation of data. The benefit of facial reconstruction is especially important since it is a way of preserving and presenting archaeological and anthropological data.
Solvent effects on terpenoid compositions and antioxidant activities of Cinnamomum camphora (L.) J. Presl extracts and the main antioxidant agent evaluation through in vitro and in vivo assay
Authors: Wang Yingying , Zhang Siyi , Ma Yuandan , Du Xianmin , Zong Qi , Lin Die , Lai Meng , Huang Tianyu , Luo Qingyun , Yang Lin , Li Zhanyong , Zuo Zhaojiang 
Published: January 2024

AbstractPlant secondary metabolites can protect organisms against oxidative stress caused by adverse environmental conditions. Cinnamomum camphora (L.) J. Presl contains plentiful terpenoids and is subdivided into 5 chemotypes. To develop natural antioxidants using the plant terpenoids, the terpenoid composition and antioxidant abilities of methanol, ethyl acetate, n-hexane and petroleum ether extracts from linalool and eucalyptol chemotypes were investigated, and the solvent effects on in vitro antioxidant activity of 8 main terpenoids were analyzed. Meanwhile, the in vivo effects of two strong antioxidant terpenoids were evaluated. For the two chemotypes, the 4 solvents exhibited the same extracting effects on the terpenoid types, but methanol extracts contained the highest content of terpenoids, which should contribute to their strongest scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals. In linalool and eucalyptol chemotype extracts, linalool, eucalyptol, ocimene, α-pinene, D-limonene, terpinene, β-pinene and longifolene were the 8 main terpenoids. Among the 4 solvents, the 8 terpenoids showed the strongest free radical-scavenging activity with methanol as the reaction medium, which might result from strong-polarity methanol easily activating C = C unsaturated bonds in these compounds. This might also contribute to the strongest scavenging activity of methanol extracts against free radicals. Among these main components, ocimene and longifolene separately showed the strongest activity in scavenging DPPH and ABTS free radical. In in vivo assay, the two compounds significantly lowered the reactive oxygen species (ROS) levels in Chlamydomonas reinhardtii, a single-celled model organism, under H2O2 stress, and the lowering effects gradually enhanced with increasing the compound concentration, resulting in the corresponding promoting effect on the algal growth. At the same concentration, longifolene showed the strongest effect on protecting the algal cells against oxidative stress. Therefore, methanol was suitable for extracting terpenoids in natural antioxidant development, and ocimene and longifolene were two strong antioxidant terpenoids without cell toxicity, with the latter having stronger in vivo antioxidant activity.
Graphical Abstract
Three policy perspectives on Japanese female employment
Authors: Guo Yunwei , Yao Yiwei , Yu Xiao 
Published: January 2024

AbstractWith a detailed historical analysis of postwar Japanese female employment, this article presents three underlying policy perspectives that shape the fact that women have less chance for high-quality employment despite the rising labor force participation rate. The three assumptions of women's role in policy-making are as follows: (1) women as housewives—dependent on males, do not earn a living salary and are thus marginalized in the labor market; (2) women as individuals pursuing gender equality should be treated without discrimination in the workplace; and (3) women as key drivers for economic growth can contribute to the solution to labor shortages. The postwar history of Japanese female employment is full of interaction among these three policy perspectives. Generally, it passes through phases of the dominance of the housewife perspective, the reformation from the equality perspective and the counterattack from the housewife perspective, as well as the mainstreaming of the economic actor perspective.
Five years of safety profile of bevacizumab: an analysis of real-world pharmacovigilance and randomized clinical trials
Authors: Wang Li , Fei Yibo , Qu Han , Zhang Haiyang , Wang Yuanyuan , Wu Zhenghua , Fan Guorong 
Published: January 2024

Abstract
Objective
Bevacizumab is a monoclonal antibody against vascular endothelial growth factor. It has a wide range of clinical applications in various cancers and retinal diseases. The drugs entered the Chinese market by a large margin in 2017, and the user population changed to some extent. This study reevaluated the safety of bevacizumab through an analysis of the World Pharmacovigilance database (Food and Drug Administration Open Vigil 2.1) in conjunction with a comprehensive meta-analysis of RCTs.

Methods
Real-world pharmacovigilance data originating from case reports were mined using Open Vigil and coded at the preferred term (PT) level using the Standardized MedDRA Query. Proportional reporting ratios (PRR) and reporting odds ratios (ROR) were used to detect safety signals. Eligible items were screened by searching PubMed, Wanfang, and Web of Science, and data were extracted for systematic review and meta-analysis using RevMan 5.4 software.

Results
Analysis of the drug pharmacovigilance database revealed that the most significant PRRs were limb decortication syndrome (PRR = 2926), stomal varices (PRR = 549), anastomotic (PRR = 457) and ureteral fistula (PRR = 406). Most safety signals at the PT level emerged as various types of injuries, toxicities, operational complications, systemic diseases, various reactions at the administration site, hematological and lymphatic disorders, and gastrointestinal disorders. Adverse reactions such as nasal septal perforation (PRR = 47.502), necrotizing fasciitis (PRR = 20.261), and hypertensive encephalopathy (PRR = 18.288) listed as rare in drug specifications should not be ignored with a high signal in the real world. A total of 8 randomized controlled trials (RCTs) were included in the meta-analysis, and the overall risk of adverse reactions following bevacizumab administration was relatively low, indicating a good safety profile (HR = 1.19, 95% CI:0.85 ~ 1.65, p = 0.32).

Conclusion
The frequent adverse reactions of bevacizumab occurring in the real world are consistent with the data provided in RCTs and drug specifications. However, adverse reactions such as nasal septum perforation, necrotizing fasciitis, hypertensive encephalopathy and so on, listed as rare in drug specifications, may have a high signal of correlation in the real world, which all requires active monitoring and timely adjustment of bevacizumab posology during its clinical use.
Temporal trends in antipsychotic prescriptions for pediatric patients using an administrative hospital database in Japan: a retrospective study
Authors: Kikuchi Daisuke , Obara Taku , Obara Ryo , Hino Hiroaki , Suzuki Naoto , Kashiwagura Shota , Watanabe Takashi , Ouchi Ryusuke , Usui Kensuke , Okada Kouji 
Published: January 2024

Abstract
Background
Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions, and other symptoms. Although treatment guidelines for schizophrenia have been established in Japan, drugs are not recommended for pediatric schizophrenia. Additionally, the temporal trends in prescribing antipsychotics for pediatric patients with schizophrenia are unclear. Therefore, we aimed to clarify the trends in antipsychotic prescriptions for Japanese pediatric outpatients from 2015 to 2022.

Methods
Administrative data (as of November 2023) of Japanese pediatric outpatients with schizophrenia aged 0–18 years who visited acute-care diagnosis procedure combination hospitals between January 1, 2015, and December 31, 2022, were included in this study. The target drugs for schizophrenia were all indicated for treating schizophrenia and marketed in Japan as of December 2022. Annual prescription trends for antipsychotics during this period were calculated based on their proportions. The Cochran–Armitage trend test was used to evaluate the proportion of prescriptions for each antipsychotic.

Results
The main drugs prescribed for these patients were aripiprazole and risperidone. Among male patients, the proportion of prescriptions for aripiprazole increased significantly from 21.2% in 2015 to 35.9% in 2022, whereas that for risperidone decreased significantly from 47.9% in 2015 to 36.7% in 2022 (both P < 0.001). Among female patients, the proportion of prescriptions for aripiprazole increased significantly from 21.6% in 2015 to 35.6% in 2022, whereas that for risperidone decreased significantly from 38.6% in 2015 to 24.8% in 2022 (both P < 0.001).

Conclusions
Aripiprazole and risperidone were primarily prescribed for pediatric schizophrenia in Japan during the study period. Additionally, the proportion of aripiprazole prescriptions increased over time.
A surgical case of anti-coagulant ileus mimicking small-bowel tumors: a case report
Authors: Masui Hideyuki , Kobayashi Hiroyuki , Sakamoto Yusuke , Yagi Shintaro , Kaihara Satoshi 
Published: January 2024

Abstract
Background
Anti-coagulant ileus, characterized by intramural hematoma due to excessive anti-coagulant therapy, presents a diagnostic challenge. Although previously considered uncommon, recently, reporting cases of anti-coagulant ileus have become more frequent. Herein, we report a rare surgical case of anti-coagulant ileus mimicking small-bowel tumors.

Case presentation
A 79-year-old man was admitted to our hospital for fatigue. He had been administered warfarin for 5 months for atrial fibrillation. On admission, the patient exhibited mild epigastric tenderness. Laboratory test results revealed anemia (hemoglobin, 8.4 g/dL); unmeasurably prolonged prothrombin time (PT) with international normalized ratio (INR) > 8; and elevated soluble interleukin 2 receptor (sIL-2R) levels (849 IU/mL; normal range, 122–496 IU/mL). Abdominal plain computed tomography (CT) showed a circumferentially thickened intestinal wall at one site in the jejunum and two in the ileum. After hospitalization, bowel obstruction did not improve with conservative treatment. Suspecting small-bowel tumors such as lymphoma, the patient subsequently underwent open surgery on day 3 after admission. No obvious tumor mass was observed intra-operatively. However, only thickened and hemorrhagic segments were identified at the suspected sites. We performed partial jejunal and ileal resections of 12 and 27 cm, respectively. Histopathology confirmed submucosal congestion, edema, and hemorrhage in each area without tumor components, leading to the final diagnosis of intramural hematoma. The postoperative course was uneventful, and he was discharged on postoperative day 9. No recurrence occurred during the 5-year follow-up period.

Conclusions
We encountered a surgical case of anti-coagulant ileus, which was difficult to differentiate from malignant lymphoma based on CT findings and high sIL-2R levels. The possibility of anti-coagulant ileus should always be considered in patients on long-term anticoagulation medication and bowel obstruction with high PT-INR values.
A unified compendium of prokaryotic and viral genomes from over 300 anaerobic digestion microbiomes
Authors: Centurion Victor Borin , Rossi Alessandro , Orellana Esteban , Ghiotto Gabriele , Kakuk Balázs , Morlino Maria Silvia , Basile Arianna , Zampieri Guido , Treu Laura , Campanaro Stefano 
Published: January 2024

Abstract
Background
The anaerobic digestion process degrades organic matter into simpler compounds and occurs in strictly anaerobic and microaerophilic environments. The process is carried out by a diverse community of microorganisms where each species has a unique role and it has relevant biotechnological applications since it is used for biogas production. Some aspects of the microbiome, including its interaction with phages, remains still unclear: a better comprehension of the community composition and role of each species is crucial for a cured understanding of the carbon cycle in anaerobic systems and improving biogas production.

Results
The primary objective of this study was to expand our understanding on the anaerobic digestion microbiome by jointly analyzing its prokaryotic and viral components. By integrating 192 additional datasets into a previous metagenomic database, the binning process generated 11,831 metagenome-assembled genomes from 314 metagenome samples published between 2014 and 2022, belonging to 4,568 non-redundant species based on ANI calculation and quality verification. CRISPR analysis on these genomes identified 76 archaeal genomes with active phage interactions. Moreover, single-nucleotide variants further pointed to archaea as the most critical members of the community. Among the MAGs, two methanogenic archaea, Methanothrix sp. 43zhSC_152 and Methanoculleus sp. 52maCN_3230, had the highest number of SNVs, with the latter having almost double the density of most other MAGs.

Conclusions
This study offers a more comprehensive understanding of microbial community structures that thrive at different temperatures. The findings revealed that the fraction of archaeal species characterized at the genome level and reported in public databases is higher than that of bacteria, although still quite limited. The identification of shared spacers between phages and microbes implies a history of phage-bacterial interactions, and specifically lysogenic infections. A significant number of SNVs were identified, primarily comprising synonymous and nonsynonymous variants. Together, the findings indicate that methanogenic archaea are subject to intense selective pressure and suggest that genomic variants play a critical role in the anaerobic digestion process. Overall, this study provides a more balanced and diverse representation of the anaerobic digestion microbiota in terms of geographic location, temperature range and feedstock utilization.
Socio-economic, demographic, and contextual predictors of malnutrition among children aged 6–59 months in Nigeria
Authors: Obasohan Phillips Edomwonyi , Walters Stephen J. , Jacques Richard , Khatab Khaled 
Published: January 2024

AbstractMalnutrition has remained a global public health issue, particularly in low- and middle-income countries (LMICs). Researchers have committed to studying malnutrition (especially in children under the age of five) to address the nine malnutrition targets, set by the WHO to be achieved by 2025. This study seeks to evaluate the prevalence, the individual and contextual predictors of malnutrition among children aged 6–59 months across Nigeria and its states. Two separates, independently collected, nationally representative cross-sectional surveys, the National Human Development Report (NHDR 2018) and the 2018 Nigeria Demographic and Health Survey (2018 NDHS) were linked for this study. Spatial map was used to describe the prevalence of malnutrition, a 3-level multivariate multilevel logistic regression models were fitted where children/individuals (at level 1) were nested in communities/clusters (at level 2) and nested in states (at level 3). A weighted sample of 7,770 children 6–59 months were considered in this study. The results showed that an estimated 43.6% of children aged 6–59 months are poorly nourished in Nigeria. The proportions of poorly nourished children were generally highest in the Northern Nigeria. Child’s gender, age, birth size, preceding birth order, anaemia status, maternal education, work status, body weight, household wealth status, number of bedrooms were among individual/household predictors of malnutrition. On the community level, being from community with high wealth index, distance to nearest health facilities is no big problem. Regional variations and gender inequality index were the state level predictors of malnutrition among children in Nigeria. This study has shown that two-third of children aged 6–59 months in Nigeria were poorly nourished, an indication of a growing concern of double burden of malnutrition in Nigeria.