bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple normalized solutions for fractional elliptic problems
Authors: Nguyen Thin Van , Rădulescu Vicenţiu D. 
Published: January 2024

Abstract
In this article, we are first concerned with the existence of multiple normalized solutions to the following fractional p-Laplace problem:

{

(

-
Δ

)

p
s

⁢
v

+

𝒱
⁢

(

ξ
⁢
x

)

⁢

|
v
|

p
-
2

⁢
v

=

λ
⁢

|
v
|

p
-
2

⁢
v

+

f
⁢

(
v
)

in
⁢

ℝ
N

,

∫

ℝ
N

|
v
|

p

⁢

𝑑
x

=

a
p

,

\left\{\begin{aligned} \displaystyle{}(-\Delta)_{p}^{s}v+\mathcal{V}(\xi x)%
\lvert v\rvert^{p-2}v&\displaystyle=\lambda\lvert v\rvert^{p-2}v+f(v)\quad%
\text{in }\mathbb{R}^{N},\\
\displaystyle\int_{\mathbb{R}^{N}}\lvert v\rvert^{p}\,dx&\displaystyle=a^{p},%
\end{aligned}\right.

where

a
,
ξ

>
0

{a,\xi>0}

,

p
≥
2

{p\geq 2}

,

λ
∈
ℝ

{\lambda\in\mathbb{R}}

is an unknown parameter that appears as
a Lagrange multiplier,

𝒱
:

ℝ
N

→

[
0
,
∞
)

{\mathcal{V}:\mathbb{R}^{N}\to[0,\infty)}

is a continuous function, and f is a continuous function with

L
p

{L^{p}}

-subcritical growth. We prove that there exists the multiplicity of solutions by using the Lusternik–Schnirelmann category. Next, we show that the number of normalized solutions is at least the number of global minimum points of

𝒱

{\mathcal{V}}

,
as ξ is small enough via Ekeland’s variational principle.
The role of matrix metalloproteinase-2 in the metastatic cascade: a review
Authors: Murray Nigel P. 
Published: January 2024

Abstract
Matrix metalloproteinase-2 (MMP-2) is a gelatinase and is involved in multiple steps of the metastatic cascade. More than a decade ago an increased expression of MMP-2 in tumour cells or higher serum levels was reported to be a prognostic biomarker for a lower disease-free and overall survival rate. In recent years new evidence has indicated that MMP-2 has an important role in the tumour ecosystem. It is one of the many players in the onco-sphere, involved in interacting between tumour cells, host cells and the microenvironment. It plays a role in the dissemination of tumour cells, the epithelial–mesenchymal and mesenchymal–epithelial transitions, the formation of the pre-metastatic and metastatic niches, dormancy of tumour cells and modulating the immune system. The aim of this review is to highlight these multiple roles in the metastatic cascade and how many signalling pathways can up or down-regulate MMP-2 activity in the different stages of cancer progression and the effect of MMP-2 on the onco-sphere. Research in head and neck cancer is used as an example of these processes. The use of non-specific MMP inhibitors has been unsuccessful showing only limited benefits and associated with high toxicity as such that none have progressed past Phase III trials. Preclinical trials are undergoing using antibodies directed against specific matrix metalloproteinases, these targeted therapies may be potentially less toxic to the patients.
Isolating neural signatures of conscious speech perception with a no-report sine-wave speech paradigm
Authors: Zhu Yunkai , Li Charlotte , Hendry Camille , Glass James , Canseco-Gonzalez Enriqueta , Pitts Michael A. , Dykstra Andrew R. 
Published: January 2024

Identifying neural correlates of conscious perception is a fundamental endeavor of cognitive neuroscience. Most studies so far have focused on visual awareness along with trial-by-trial reports of task relevant stimuli, which can confound neural measures of perceptual awareness with post-perceptual processing. Here, we used a three-phase sine-wave speech paradigm that dissociated between conscious speech perception and task relevance while recording EEG in humans of both sexes. Compared to tokens perceived as noise, physically identical sine-wave speech tokens that were perceived as speech elicited a left-lateralized, near-vertex negativity, which we interpret as a phonological version of a perceptual awareness negativity. This response appeared between 200 and 300 ms after token onset and was not present for frequency-flipped control tokens that were never perceived as speech. In contrast, the P3b elicited by task-irrelevant tokens did not significantly differ when the tokens were perceived as speech versus noise, and was only enhanced for tokens that were both perceived as speechandrelevant to the task. Our results extend the findings from previous studies on visual awareness and speech perception, and suggest that correlates of conscious perception, across types of conscious content, are most likely to be found in mid-latency negative-going brain responses in content-specific sensory areas.Significance StatementHow patterns of brain activity give rise to conscious perception is a fundamental question of cognitive neuroscience. Here, we asked whether markers of conscious speech perception can be separated from task-related confounds. We combined sine-wave speech - a degraded speech signal that is heard as noise by naive individuals but can readily be heard as speech after minimal training - with a no-report paradigm that independently manipulated perception (speech versus non-speech) and task (relevant versus irrelevant). Using this paradigm, we were able to identify a marker of speech perception in mid-latency responses over left frontotemporal EEG channels that was independent of task. Our results demonstrate that the “perceptual awareness negativity” is present for a new type of perceptual content (speech).
An approximation of the Hurwitz zeta function by a finite sum
Authors: Garunkštis Ramūnas 
Published: January 2024

We obtain the following version of the approximation of the Hurwitz zeta-function. Let σ ≥ 0 and |t| ≤ π x. Thenζ(s, α) = ∑0 ≤ n ≤ x 1/(n + α)s +{ (x + α)1−s}/(s − 1) + Θ ({7√2π−1 + 3}/xσ).
A three-wave longitudinal study on the underlying metacognitive mechanism between depression and Internet gaming disorder
Authors: Dang Le , Yang Hong Mian , Spada Marcantonio M. , Wu Anise M. S. 
Published: January 2024

AbstractBackground and aims: Internet Gaming Disorder (IGD) and depression have negative consequences on individuals' mental health, but their relationships are complex. This three-wave longitudinal study aimed to detect the metacognitive mechanisms underlying the association between IGD tendency and depression based on the self-regulatory executive function model. Methods: A total of 1,243 Chinese undergraduate student gamers (57% female, M = 19.77, SD = 1.29) were recruited at the baseline survey (Wave 1 [W1]), with 622 and 574 of them taking part in the two follow-up surveys (Wave 2 [W2] at 6 and Wave 3 [W3] at 12 months later), respectively. Results: The three-wave path model demonstrated, after controlling for the autoregressive effect of each variable, that depression consistently predicted IGD tendency but not vice versa, while negative but not positive metacognitions about online gaming (MOG) significantly predicted both depression and IGD tendency. Moreover, two statistically significant mediation paths: (i) negative MOG [W1] → depression [W2] → IGD tendency [W3]; and (ii) depression [W1] → negative MOG [W2] → IGD tendency [W3] were identified. Discussion and conclusions: These findings extend the understanding of the associations among depression, IGD tendency, and MOG, highlighting how negative MOG has a stronger prospective effect than positive MOG on depression and IGD tendency, and also reveal the mutual mediation effects of depression and negative MOG on IGD tendency. Integrated programmes with both emotional regulation training and Metacognitive Therapy are recommended for IGD treatment.
Determinism of Media Technology and Distortion of Siri’ Culture
Authors: Qadaruddin Muhammad , Bakri Wahyuddin , Md Shah Jalihah , Cahyadi Irlan , Sasriani Andini 
Published: January 2024

The rapid development of communication technology, particularly in social media platforms such as Facebook, TikTok, and Instagram, profoundly influences the entire human experience. The influence includes cultural shifts among adolescents, precisely distortions to the "Siri" culture that affect their self-concept, self-esteem, and self-image. This qualitative research aimed to analyze changes in the Siri’ culture in communication among adolescents, the impact of communication media technology, and indicators of Siri' character building. The data was collected through observations, surveys, and interviews. The results showed two main findings: first, in the culture of adolescents in Parepare City, Siri’ is interpreted as a local philosophy that emphasizes the importance of maintaining self-respect in the daily style, speech, and behavior. It has a direct impact on the formation of adolescents' self-concept. The second, media technology has a significant influence on cultural changes and adolescents' self-concept (macca, lempu, warani, getting), self-esteem (penggalik), and self-image (malebbi, mekkeade, makanja).
ECONOMÍA CIRCULAR UNA EXPERIENCIA DE INNOVACIÓN
Authors: Luque Martínez Inírida , Ospina Luz Mary , Rodríguez Deisy Andrea , Cerón Mario , Uribe Arévalo Aura 
Published: January 2024

El año 2023 está dejando cifras récord de calentamiento global, la comunidad científica alerta sobre los posibles efectos negativos para la supervivencia de especies. En el 2022 la temperatura media mundial fue aproximadamente 1,15°C superior a los datos históricos (ONU), no obstante seguimos con el mismo modelo de consumo que ha marcado el desarrollo desde el siglo XX, el uso de materias primas para ser transformado por la industria en productos que luego la población consume y desecha, a esta forma de producir y consumir se le llama el “modelo lineal”; modelo que debe replantearse y cambiar a un modelo más sensato y con menores impactos ambientales que se denominada “economía circular”. En este modelo se pretende que todo lo que se utiliza en la producción, en particular los desechos, pueden tener otra oportunidad en la cadena productiva, es decir, impulsar el aprovechamiento de recursos y residuos, dándole así al planeta tiempo y oportunidad de regeneración.
La ONU ha declarado una serie de objetivos en la llamada agenda 2030, con la que todos los países miembros deben comprometerse para mitigar los efectos del deterioro ambiental y lograr la sostenibilidad de la vida, son 17 los objetivos y en particular el No. 11 puede orientarse a los postulados de la economía circular: “Lograr que las ciudades y los asentamientos humanos sean inclusivos, seguros, resilientes y sostenibles”.
Este contexto da lugar a investigaciones que ofrezcan alternativas de cambio o soluciones para enfrentar el deterioro ambiental y darle un giro a esta realidad. Este artículo tiene como objetivos divulgar y dar conocer una experiencia empresarial de reconciliación con el entorno a partir de la economía circular, se pretende resaltar cómo la visión empresarial, el compromiso social han sido los impulsores de un modelo de negocio con un cambio de pensamiento. Se realiza como una investigación de tipo cualitativa, descriptiva y documental, mediante la búsqueda de artículos científicos y la entrevista directa, para la obtención de información que permitan entender el proceso de implementación de la ruta de la economía circular diseñada por la empresa GODOS PLAZA CENTER, ubicada en la ciudad de Machala-Ecuador y como resultado final se busca consolidar un caso de estudio.
Correlação entre o pH do ambiente aquático superficial e subterrâneo e a pKa na ionização do agrotóxico e a contribuição para contaminação da água
Authors: Mendes Luzia Suerlange Araújo dos Santos , Lima Eveline Cunha , Sousa Joyce Shantala Fernandes de Oliveira , Silva Neto Tomaz Alexandre da , Cavalcante Itabaraci Nazareno 
Published: January 2024

O comportamento de um agrotóxico no ambiente depende das propriedades físicas e químicas do meio. A migração dessas substâncias entre as matrizes ambientais depende das propriedades físico-químicas como pH e a constante de equilíbrio de ionização ácido ou base (pKa), onde definem o tempo de permanência dessas substâncias no ambiente, tendo em vista que pH mais ácido são mais propícios um tempo maior de permeância no ambiente. Nesse contexto, a pesquisa teve como objetivo correlacionar os valores de pH, medidos nas amostras de águas coletadas em ambiente aquático superficial, canal de irrigação do Perímetro Irrigado tabuleiro de Russas (PITR), e subterrâneo no município de Russas – Ceará. As propriedades foram analisadas em quatro ciclos de coletas para os agrotóxicos: Acefato, Aldicarbe, Ametrina, Dimetoato, Imidacloprido, Permetrina e Tebuconazol. Os valores de pKa dos agrotóxicos foram obtidos da International Union of Pure and Applied Chemistry (IUPAC), as medidas de pH foram realizadas in situ. O estudo mostrou que os resultados apresentam tendência ácida das amostras coletada nos períodos chuvosos, o que favorece a lixiviação de substâncias e um maior tempo de permanência no ambiente. Observa-se, ainda, que as águas do PITR apresentaram tendência básica, e se deve, possivelmente, pela presença de matéria orgânica ao longo do canal. Nesse estudo foi observado que as substâncias, Acefato e Tebuconazol, são ácidos fraco de intensidade moderada, que pode permanecer maior tempo no ambiente; já o Aldicarbe e a Ametrina são ácidos muito fracos com intensidade moderada.
Indicadores Urbanos de Meio Ambiente: Estudo de Caso de Passo Fundo-RS
Authors: Campestrini Júlia Brum , Silva Thaísa Leal da 
Published: January 2024

A rápida urbanização resulta em diversos desafios relacionados à infraestrutura urbana, e possuem dificuldades para traçar novas soluções de melhorias, adequação e planos para um melhor desenvolvimento urbano. Nesse contexto, este estudo tem o objetivo de analisar os indicadores urbanos de Meio Ambiente da cidade de Passo Fundo, no norte do Rio Grande do Sul, segundo o Ranking Connected Smart Cities (RCSC) a fim de identificar pontos positivos e negativos no dos indicadores analisados em relação ao objeto de estudo. Para isso, a metodologia de pesquisa foi dividida nas seguintes etapas: revisão bibliográfica, diagnóstico da cidade, levantamento dos indicadores do eixo de Meio Ambiente analisado, e comparação dos indicadores de Passo Fundo/RS com os indicadores das cidades de médio porte da Região Sul do Brasil mais bem classificadas no Ranking nos anos de 2019, 2020 e 2021. A partir da comparação dos resultados foi possível verificar o desenvolvimento de Passo Fundo durante os três anos de análise, averiguando que houve uma preocupação com investimentos para melhoria de infraestruturas e serviços voltados ao Meio Ambiente. Com o estudo, foi possível perceber que Passo Fundo busca melhorar seus serviços, mas carece de atenção no âmbito dos índices de perdas de água durante a sua distribuição e à coleta e tratamento de esgoto da cidade. Além disso, notou-se a importância de mensurar e monitorar indicadores urbanos para que contribuir para o planejamento de novas diretrizes municipais, e para o desenvolvimento de iniciativas de combate e prevenção de problemas urbanos voltados a saúde.
A permacultura como referencial para adequação curricular para as escolas do campo jurisdicionadas a Diretoria de Ensino da Região de Mirante do Paranapanema/SP
Authors: Gonçalves Moacir , Okimoto Fernando Sérgio 
Published: January 2024

A educação do campo é uma metodologia de educação que procura vincular o as disciplinas da Base Nacional Comum Curricular com as especificidades dos saberes e vivências da comunidade que reside no meio rural, promovendo a sua emancipação. Para que ela ocorra é necessária toda uma mudança nas escolas instaladas na zona rural, principalmente em seus Projetos Político Pedagógicos que deve refletir a identidade local. As políticas públicas de educação brasileira gestadas e implementadas nos últimos anos tanto em nível federal, quanto estadual, fruto de uma visão neoliberal, acabaram direcionando o ensino nas escolas a currículos engessados, pouca autonomia do professor e desconexão do que é ensinado à vivência dos alunos. Consequentemente tornou muito difícil a metamorfose das escolas rurais para escolas do campo. Na área atendida pela Diretoria de Ensino da Região de Mirante do Paranapanema existe onze escolas instaladas em projetos de assentamentos rurais que seguem a política educacional tradicional. Estas escolas podem cumprir melhor o seu papel de agente de promoção social se adotasse as premissas da educação do campo. A permacultura, ao trabalhar temas de todas as áreas do conhecimento humano com objetivos de realizar uma relação sustentável entre homem e natureza, pode ser o eixo integrador para a transformação destas escolas. Os desafios são enormes, porém a disseminação do conhecimento acerca dos referenciais da educação do campo e da permacultura podem ser o elemento disparador da mobilização das comunidades rural e escolar para transformação de suas escolas.
Role of dermoscopy in hyperpigmented skin disorders: A tertiary care centre experience
Authors: Oza Rutu Harsh , Agrwal Shreya , Tank Jaydipkumar , Sutaria Amita , Parmar Kirti S , Shah Bela J , Chaudhary Navin R , Saini Kriteeka , Vyas Harshita , Shah Shikha R , Mistry Deval 
Published: January 2024

Dermoscopy, performed with a handheld instrument called dermatoscope, is a non-invasive and in-vivo technique for the evaluation of various skin lesions in clinical practice. Although many studies have shown the importance of dermoscopy in diagnosing skin lesions by supplementing naked-eye evaluation, Indian data on its usefulness is scarce. We aimed to describe dermoscopic findings in various pigmented conditions in skin of colour.A retrospective observational study was carried out in a tertiary care hospital in western India for the period of two years- October 2015 to September 2018. Patients were selected from the available records by using pre-specified selection criteria. Detailed demographic and clinical parameters were recorded. The dermoscopic examination was done using Dermlite DL3 polarised device. The histopathological findings, when available, were also evaluated. A total of 352 patients were identified, 181 males and 171 females. Out of the total number, 272 patients had melanocytic and 80 had non-melanocytic lesions. Benign melanocytic nevi (100 out of 272) and seborrheic keratosis (58 out of 70) were the most common observations for melanocytic and non-melanocytic lesions respectively. The study provides real-world data on a large scale for dermoscopic findings in hyperpigmented lesions in Indian patients. This study corroborates with observations from previous studies to suggest quick and non-invasive use of dermoscopy for reliable diagnosis. Larger studies in future may obviate the need for biopsy while managing these patients.
A clinico-epidemiological study of breast eczema sparing nipple and areola from a tertiary care hospital in western Rajasthan
Authors: Awake Praneet , Verma Manjulata , Waghmare Swagat , Kachhawa Dilip , Sharma Deepak 
Published: January 2024

Nipple eczema can be a local manifestation of atopic dermatitis/eczema when it arises with classic age-related patterns of eczema on other body sites, or it can occur in isolation. In our study, breast eczema sparing nipple and areola, was observed in females of western Rajasthan. This study reports the demography, clinico-morphological patterns and factors causing it. After due informed consent, thirty consecutive female patients of breast eczema were undergone a detailed history, clinical examination and patch testing. Hamilton Anxiety Rating Scale was used for anxiety severity assessment. Most common site of breast eczema was the upper-outer quadrant (15/30) followed by upper-inner quadrant (9/30). The cell-phone was the most common object which was kept in close contact with the breast followed by purse (26/30) and money (11/30). Total 20 positive patch tests were seen in 17 patients. Fifteen patch tests were relevant to the current dermatitis. Mild anxiety cases were significantly more in acute type whereas moderate-severe type was more with chronic type (p value=0.021). Larger study is required to establish the exact cause of this type of breast eczema. Breast eczema seems to have diverse etiology, supplemented by various factors such as anxiety, perspiration in hot arid weather, traditional loosely-fit inner clothing of women in this region of western Rajasthan and friction produced by the objects (cell phones) that are kept in contact with breasts, work together to produce dermatitis.
A case control study of risk factors in chronic urticaria
Authors: Godse Kiran , Tiwari Kritika , Patidar Vatsal , Patil Sharmila , Nadkarni Nitin 
Published: January 2024

Urticaria presents as erythematous, often pruritic, raised transient wheals. The aetiology of Chronic Urticaria (CU) is not well understood. Autoimmunity, chronic infections, allergens and metabolic syndrome are some known implicated factors. But the role of life style factors like diet, smoking, alcohol, occupation, family history etc is relatively unknown. This study aims to uncover the role of these modifiable factors in causation of CU.Data from 20 individuals with chronic urticaria (duration &#60;1 year) and 20 age and sex matched Controls (healthy/patients without chronic urticaria) was collected using questionnaires to assess lifestyle and risk factors like diet, alcohol consumption, smoking, medications, stress, sleep etc in the implication of CU.Our study revealed notable if not significant associations. Out of these, 6 cases (30%) had a family history of CU, while 10 cases (50%) had a prior history of acute urticaria episodes. Additionally, 6 cases (30%) reported food allergies, and 10 cases (50%) had a documented medical history. Furthermore, 7 cases (35%) reported insect bites as a factor, while 1 case (5%) was linked to H. Pylori infections. Notably, 12 cases (60%) showed a lower consumption of fruits, while 9 cases (45%) exhibited a relatively higher intake of foods containing dyes and additives. These findings collectively suggest some potential connections in the development of CU.This study underscores the intricate connections between risk factors, lifestyle choices, and CU. Differences in sleep quality, food allergies, dietary habits, and seafood consumption provide potential insights into associations. This investigation may contribute to improved CU management approaches.