bluuebunny/crossref_metadata_2025_split huggingface dataset:
EBF2 Links KMT2D‐Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN
Authors: Yao Bing , Xing Mengying , Meng Shixin , Li Shang , Zhou Jingwan , Zhang Ming , Yang Chen , Qu Shuang , Jin Yucui , Yuan Hongyan , Zen Ke , Ma Changyan 
Published: November 2023

AbstractMono‐methylation of histone H3 on Lys 4 (H3K4me1), which is catalyzed by histone‐lysine N‐methyltransferase 2D (KMT2D), serves as an important epigenetic regulator in transcriptional control. In this study, the authors identify early B‐cell factor 2 (EBF2) as a binding protein of H3K4me1. Combining analyses of RNA‐seq and ChIP‐seq data, the authors further identify killin (KLLN) as a transcriptional target of KMT2D and EBF2 in pancreatic ductal adenocarcinoma (PDAC) cells. KMT2D‐dependent H3K4me1 and EBF2 are predominantly over‐lapped proximal to the transcription start site (TSS) of KLLN gene. Comprehensive functional assays show that KMT2D and EBF2 cooperatively inhibit PDAC cells proliferation, migration, and invasion through upregulating KLLN. Such inhibition on PDAC progression is also achieved through increasing H3K4me1 level by GSK‐LSD1, a selective inhibitor of lysine‐specific demethylase 1 (LSD1). Taken together, these findings reveal a new mechanism underlying PDAC progression and provide potential therapeutic targets for PDAC treatment.
Mechanical Motion Tuned Carrier Transport Characteristic of Dynamic Diode
Authors: Yang Zunshan , Zhong Huikai , Wang Can , Lu Yanghua , Feng Lixuan , Yu Xutao , Liu Chang , Lin Shisheng 
Published: November 2023

AbstractSince the invention of the dynamic diode, its physical properties and potential applications have attracted wide attention. Lots of attempts are made to harvest the rebounding current and voltage of the dynamic diode. However, the underlying physical mechanism of its carrier transport characteristic is rarely explored carefully. Here, the electrical transport properties of the dynamic diode are systematically investigated with a mechanical motion‐tuned method, where the dynamic current‐voltage (I‐V) curve shows a gentler growth trend compared to the static curve. The rebounding current increases with motion velocity and contact force, resulting in a reduced current with the same bias voltage and an oscillation current with a changing velocity and force. This study shows a physical picture of adjusting microscopic carrier motion with macroscopic mechanical motion, which provides strong theoretical support for designing dynamic diode devices with better performance in the future.
An Ultrahigh‐Rectification‐Ratio WSe2 Homojunction Defined by High‐Efficiency Charge Trapping Effect
Authors: Wang Lihua , He Xiaoyu , Zhang Xiankun , Wei Xiaofu , Chen Kuanglei , Gao Li , Yu Huihui , Hong Mengyu , Zhang Zheng , Zhang Yue 
Published: November 2023

AbstractAlthough 2D material van der Waals heterostructures (vdWHs) exhibit many novel properties and applications, 2D homojunctions have unique advantages in interface lattice matching, band continuity, and charge transfer efficiency. However, the rectification performances of 2D homojunction diodes are severely limited by the small junction barrier, mainly due to inefficient charge doping. In this work, an ultrahigh‐rectification‐ratio WSe2 homojunction diode achieved by the semi‐floating gate doping of graphdiyne oxide (GDYO) is reported. Utilizing the WSe2/GDYO direct charge trapping mode can free the inhibition of charge capturing efficiency by removing conventional insulating barriers and thus improve the rectification ratio. The C─C(sp) and oxygen‐containing functional groups in the GDYO layer can provide outstanding charge‐trapping ability due to their unsaturation. Furthermore, the oxygen plasma treatment used for oxidizing graphdiyne (GDY) into GDYO can make GDYO a flatter surface, thus creating strong‐coupling WSe2/GDYO interfaces to improve the charge transfer efficiency and enhance the electrostatic doping effect. Besides, the WSe2/GDYO interfaces are confirmed to possess a higher junction barrier than that of the WSe2/GDY interfaces. This research proposes a brand‐new approach to building p–n junctions via charge trapping and the homojunction diode with a record‐highest rectification ratio of up to 106 is obtained.
Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK‐ADRC cohort
Authors: Foley Kate E. , Winder Zachary , Sudduth Tiffany L. , Martin Barbara J. , Nelson Peter T. , Jicha Gregory A. , Harp Jordan P. , Weekman Erica M. , Wilcock Donna M. 
Published: November 2023

AbstractINTRODUCTIONProtein‐based plasma assays provide hope for improving accessibility and specificity of molecular diagnostics to diagnose dementia.METHODSPlasma was obtained from participants (N = 837) in our community‐based University of Kentucky Alzheimer's Disease Research Center cohort. We evaluated six Alzheimer's disease (AD)‐ and neurodegeneration‐related (Aβ40, Aβ42, Aβ42/40, p‐tau181, total tau, and NfLight) and five inflammatory biomarkers (TNF𝛼, IL6, IL8, IL10, and GFAP) using the SIMOA‐based protein assay platform. Statistics were performed to assess correlations.RESULTSOur large cohort reflects previous plasma biomarker findings. Relationships between biomarkers to understand AD–inflammatory biomarker correlations showed significant associations between AD and inflammatory biomarkers suggesting peripheral inflammatory interactions with increasing AD pathology. Biomarker associations parsed out by clinical diagnosis (normal, MCI, and dementia) reveal changes in strength of the correlations across the cognitive continuum.DISCUSSIONUnique AD–inflammatory biomarker correlations in a community‐based cohort reveal a new avenue for utilizing plasma‐based biomarkers in the assessment of AD and related dementias.Highlights
Large community cohorts studying sex, age, and APOE genotype effects on biomarkers are few.
It is unknown how biomarker–biomarker associations vary through aging and dementia.
Six AD (Aβ40, Aβ42, Aβ42/40, p‐tau181, total tau, and NfLight) and five inflammatory biomarkers (TNFα, IL6, IL8, IL10, and GFAP) were used to examine associations between biomarkers.
Plasma biomarkers suggesting increasing cerebral AD pathology corresponded to increases in peripheral inflammatory markers, both pro‐inflammatory and anti‐inflammatory.
Strength of correlations, between pairs of classic AD and inflammatory plasma biomarker, changes throughout cognitive progression to dementia.
Ultrafast Surface‐Specific Spectroscopy of Water at a Photoexcited TiO2 Model Water‐Splitting Photocatalyst
Authors: Backus Ellen H. G. , Hosseinpour Saman , Ramanan Charusheela , Sun Shumei , Schlegel Simon J. , Zelenka Moritz , Jia Xiaoyu , Gebhard Maximilian , Devi Anjana , Wang Hai I. , Bonn Mischa 
Published: November 2023

AbstractA critical step in photocatalytic water dissociation is the hole‐mediated oxidation reaction. Molecular‐level insights into the mechanism of this complex reaction under realistic conditions with high temporal resolution are highly desirable. Here, we use femtosecond time‐resolved, surface‐specific vibrational sum frequency generation spectroscopy to study the photo‐induced reaction directly at the interface of the photocatalyst TiO2 in contact with liquid water at room temperature. Thanks to the inherent surface specificity of the spectroscopic method, we can follow the reaction of solely the interfacial water molecules directly at the interface at timescales on which the reaction takes place. Following the generation of holes at the surface immediately after photoexcitation of the catalyst with UV light, water dissociation occurs on a sub‐20 ps timescale. The reaction mechanism is similar at pH 3 and 11. In both cases, we observe the conversion of H2O into Ti−OH groups and the deprotonation of pre‐existing Ti−OH groups. This study provides unique experimental insights into the early steps of the photo‐induced dissociation processes at the photocatalyst‐water interface, relevant to the design of improved photocatalysts.
‘It's a magnifying glass for your relationship’: a thematic analysis of motivations, benefits, and challenges in consensually non‐monogamous relationships
Authors: Codrington Rebecca , du Plooy Daniel R. 
Published: November 2023

AbstractThe last decade has seen an increase in public and academic interest in consensual non‐monogamy (CNM). CNM involves sexual and/or romantic relationships between multiple partners, with the consent of all individuals involved. Engagement in CNM is estimated at 5% of the general population, although due to stigma with the strong idealisation of monogamy in many cultures, it is a hidden population. This qualitative study explores the motivations, benefits, and challenges experienced in CNM relationships, an area that has been understudied despite the resurgence of interest in it. While previous research has mainly focused on comparisons between CNM and monogamy or individual types of CNM such as polyamory, this study seeks to provide a broader understanding of CNM relationships. We employ a critical realist framework and thematically analyse semi‐structured interviews with eight participants. The results identify three overarching themes: mononormativity and cultural norms; growth and responsibility; and diversity and complexity; each has several subthemes. These findings suggest that CNM provides opportunities for greater diversification of needs and increased community and individual growth. The study also highlights the challenges experienced in CNM relationships and the strategies used to manage them, such as personal responsibility for managing difficult emotions and temporarily closing a relationship at times for relationship security. A novel finding in this study is that some individuals involved in CNM have internalised cultural norms and the idealisation of monogamy and need to unlearn these norms. This study adds to the existing knowledge on CNM and is expected to be of interest to clinicians and researchers seeking to understand its motivations, benefits, and challenges. Relationship therapists will benefit from increased knowledge of how to work with clients interested or engaged in CNM relationships. Overall, this study supports previous findings that CNM is a viable, enjoyable, yet sometimes challenging type of relationship.
Statistics of sudden stratospheric warmings using a large model ensemble
Authors: Ineson Sarah , Dunstone Nick J. , Scaife Adam A. , Andrews Martin B. , Lockwood Julia F. , Pang Bo 
Published: November 2023

AbstractUsing a large ensemble of initialised retrospective forecasts (hindcasts) from a seasonal prediction system, we explore various statistics relating to sudden stratospheric warmings (SSWs). Observations show that SSWs occur at a similar frequency during both El Niño and La Niña northern hemisphere winters. This is contrary to expectation, as the stronger stratospheric polar vortex associated with La Niña years might be expected to result in fewer of these extreme breakdowns. Here we show that this similar frequency may have occurred by chance due to the limited sample of years in the observational record. We also show that in these hindcasts, winters with two SSWs, a rare event in the observational record, on average have an increased surface impact. Multiple SSW events occur at a lower rate than expected if events were independent but somewhat surprisingly, our analysis also indicates a risk, albeit small, of winters with three or more SSWs, as yet an unseen event.
Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways
Authors: Takahashi Hiroki , Ito Ryo , Matsumura Yoshihiro , Sakai Juro 
Published: November 2023

AbstractOrganisms must adapt to environmental stresses to ensure their survival and prosperity. Different types of stresses, including thermal, mechanical, and hypoxic stresses, can alter the cellular state that accompanies changes in gene expression but not the cellular identity determined by a chromatin state that remains stable throughout life. Some tissues, such as adipose tissue, demonstrate remarkable plasticity and adaptability in response to environmental cues, enabling reversible cellular identity changes; however, the mechanisms underlying these changes are not well understood. We hypothesized that positive and/or negative “Integrators” sense environmental cues and coordinate the epigenetic and transcriptional pathways required for changes in cellular identity. Adverse environmental factors such as pollution disrupt the coordinated control contributing to disease development. Further research based on this hypothesis will reveal how organisms adapt to fluctuating environmental conditions, such as temperature, extracellular matrix stiffness, oxygen, cytokines, and hormonal cues by changing their cellular identities.
Accelerating wound healing: Unveiling synergistic effects of P25/SWCNT/Ag and P25/rGO/Ag nanocomposites within PRP‐gelatin scaffold, highlighting the synergistic antimicrobial activity
Authors: Gomaa Salma , Elkodous Mohamed Abd , EL‐Sayed Abeer I. M. , Tohamy Hossam , Abou‐Ahmed Howaida , Abdelwahed Ramadan , Elkhenany Hoda 
Published: November 2023

AbstractWound healing is a multifaceted biological process requiring innovative strategies to enhance efficiency and counter infections. In this groundbreaking study, we investigate the regenerative potential of platelet‐rich plasma (PRP) integrated into a gelatin (GLT) scaffold along with nanocomposites of titanium dioxide (TiO2) (P25)/single‐walled carbon nanotubes (SWCNTs)/Ag and P25/reduced graphene oxide (rGO)/Ag. Incorporating these advanced materials into the PRP/GLT delivery system aims to optimize the controlled release of growth factors (GFs) and leverage the exceptional properties of nanomaterials for enhanced tissue repair and wound healing outcomes. Antioxidant activity assessment using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity reveals the superior performance of P25/SWCNTs/Ag compared to P25/rGO/Ag. Their synergistic effects are evaluated in conjunction with antibacterial and antifungal antibiotics. Furthermore, the wound healing potential of P25/SWCNTs/Ag and P25/rGO/Ag, combined with PRP/GLT, is examined. Notably, both nanocomposites exhibit promising synergistic effects with gentamicin and fluconazole against pathogenic strains. Significantly, the inclusion of non‐activated PRP substantially augments the wound healing efficacy of P25/SWCNTs/Ag on days 3 (p < 0.01) and 15 (p < 0.05). These findings pave the way for advanced wound dressing and therapeutic interventions, capitalizing on the synergistic effects of PRP and nanomaterials, thus ultimately benefiting patients and advancing regenerative medicine.
Inclusive business for rural development: New typology and differentiated value creation in the agri‐food sector
Authors: Weng Xiaoxue , Schoneveld George C. , Pokorny Benno , Mutayoba Geofrey , Fold Niels , Gallagher Emily J. , Ezekiel Edward , van der Haar Selma 
Published: November 2023

AbstractInclusive businesses (IBs) resonate with policymakers seeking to leverage private capital in support of poverty alleviation and sustainable development. In the agri‐food sector, which represents the largest segment of the base‐of‐the‐pyramid (BOP) market and a key source of livelihood for the rural poor, there is limited evidence on their diversity and social value creation mechanisms. This prevents practitioners from identifying impactful IB types and design features. A statistical analysis of 46 cases in Tanzania and Ghana identified four IB types: (1) self‐reliant agribusinesses, (2) domestic plantation companies, (3) social enterprises, and (4) locally‐embedded Small and medium‐sized enterprises (SMEs). Our findings suggest that socially‐driven and localized IBs hold high impact potential but require significant external support, while more self‐sufficient IBs adopt less socially innovative designs. This study demonstrates the utility of a data‐driven approach to capture the complexity of real‐world IBs, which yielded practical insights for more effective poverty alleviation through business means.
Increased STX3 transcript and protein levels were associated with poor prognosis in two independent cohorts of esophageal squamous cell carcinoma patients
Authors: Shinozuka Takahiro , Kanda Mitsuro , Sato Yusuke , Shimizu Dai , Tanaka Chie , Umeda Shinichi , Inokawa Yoshikuni , Hattori Norifumi , Hayashi Masamichi , Nakayama Goro , Kodera Yasuhiro 
Published: November 2023

AbstractBackgroundSome conventional prognostic biomarkers for esophageal squamous cell carcinoma (ESCC) have the disadvantage that they have only been investigated at the level of either mRNA or protein levels or only in individual cohorts. Associations between Syntaxin 3 (STX3) expression and malignancy have been reported in several tumor types but not in ESCC. Here, we investigated the levels of both STX3 mRNA and protein, and its prognostic potential in two independent cohorts of patients with ESCC.MethodsSTX3 mRNA levels were examined in surgical specimens by quantitative PCR in a cohort that included 176 ESCC patients. STX3 protein levels were investigated in surgically resected ESCC tissues by immunohistochemistry using tissue microarrays in a different cohort of 177 ESCC patients. Correlations were analyzed between the expression of STX3 mRNA and protein with clinicopathological factors and long‐term prognosis.ResultsQuantitative PCR indicated a significant association between high level of STX3 mRNA expression and lymph node involvement, pathological stage, and poor overall survival. The multivariate analysis demonstrated that high STX3 mRNA expression was independently associated with poor overall survival outcomes. Immunohistochemistry revealed that STX3 protein expression in ESCC tissues and high STX3 protein expression were also significantly correlated with unfavorable overall survival.ConclusionsOverexpression of STX3 mRNA and protein may serve as potential prognostic biomarkers for ESCC patients.
New Facts on the Antimicrobial Essential Oil of Satureja kitaibelii
Authors: Dimitrijević Marija V. , Miladinović Ljiljana C. , Marković Marija S. , Arsić Biljana , Mihajilov‐Krstev Tatjana M. , Miladinović Dragoljub L. 
Published: November 2023

AbstractThe objective of the present study was to assess the difference in antimicrobial activity of Satureja kitaibelii Wierzb. ex Heuff. essential oil at three growth stages. In addition, using statistical and chemometric tools, we tried to explain why the essential oil from a certain vegetation stage shows the highest antimicrobial activity. S. kitaibelii essential oils demonstrated minimum inhibitory concentration values from 160 to 10000 μg mL−1, and minimum microbicidal concentration values from 630 to 20000 μg mL−1. Geraniol, borneol, limonene and p‐cymene are the dominant compounds of S. kitaibelii essential oil. The most abundant compound, geraniol, possesses antimicrobial activity in a range of MIC values from 40 to 5000 μg mL−1 and MMC values from 80 to 10000 μg mL−1. The highest activity of essential oil for all tested strains of microorganisms was recorded in November. Results of statistical analysis indicate that the percentage of dominant compounds of essential oils does not affect the antibacterial activity of essential oils. Chemometric analyses leads to the conclusion that borneol, spathulenol, caryophyllene oxide and limonene can be the main contributors to the antibacterial activity of essential oil from November and that their mutual ratio is important. These results may represent a new methodological approach for future research on essential oils.
Assessing the Chemical Composition, Antioxidant and enzyme Inhibitory Effects of Pentapleura subulifera and Cyclotrichium glabrescens Extracts
Authors: Nilofar Nilofar , Zengin Gokhan , Acar Mikail , Bouyayha Abdelhakim , Youssra Aalilou , Eldahshan Omayma , Fayez Shaimaa , Fahmy Nouran 
Published: November 2023

AbstractThe Lamiaceae family, encompassing diverse plant species, holds significant value in food, medicine, and cosmetics. Within this family, Pentapleura subulifera and Cyclotrichium glabrescens, relatively unexplored species, were investigated for their chemical composition, antioxidant capacity, and enzyme‐inhibiting effects. The chemical composition of hexane, methanolic, and aqueous extracts from P. subulifera and C. glabrescens were analyzed using LC‐ESI‐MS/MS and the non‐polar hexane fraction was investigated via GC‐MS. The antioxidant potential of the extracts was determined through radical scavenging, reducing power and metal chelating assays. Additionally, inhibitory activity against six enzymes – acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase – was examined. The aqueous extract of P. subulifera and the methanolic extract of C. glabrescens exhibited elevated phenolic content at 129.47 mg gallic acid equivalent (GAE)/g and 55.97 mg GAE/g, respectively. Chemical profiling of the constituents of the two plant species resulted in the identification of a total of twenty compounds. The majority of which belonged to flavonoids and quinic acid derivatives, primarily concentrated in the methanol and aqueous extracts. Among all antioxidant assays, the aqueous extracts of P. subulifera demonstrated superior antioxidant activity, with the highest recorded activity of 404.93 mg trolox equivalent (TE)/g in the cupric reducing antioxidant capacity (CUPRAC) test. Meanwhile, the hexane extract of C. glabrescens exhibited the highest AChE inhibitory activity at 2.71 mg galanthamine equivalent (GALAE)/g, followed by the methanol extract of P. subulifera at 2.41 mg GALAE/g. These findings unequivocally establish the notable antioxidant and enzyme inhibitory activity of P. subulifera and C. glabrescens extracts, underscoring their potential as a source of valuable natural antioxidants.
Modeling of Enhanced Oil Recovery Using Nanofluid
Authors: Godiwal Rishabh , Mandal Monisha Mridha 
Published: November 2023

AbstractNanofluid flow in porous media was modeled for enhanced oil recovery. The effects of parameters such as the matrix porosity, nanoparticles, and diffusion coefficients on the oil recovery factor were reported. The velocity, temperature, and oil saturation contours were examined. The study showed that the oil recovery and heat transfer were enhanced by the use of a nanofluid. A 30 % and 10 % increase in the oil recovery factor were found using the Al2O3‐water nanofluid as compared to water and the polystyrene‐water nanofluid, respectively. The temperature in the porous matrix was significantly reduced by the Al2O3‐water nanofluid as compared to the polystyrene‐water nanofluid and water. In the future, this model could be used to screen the performance of other chemical agents and eventually lead to a more efficient and sustainable oil extraction process.
Radical‐Formation Management: Towards Aza‐Analogues of the Benzothioxanthene Imide
Authors: Sánchez Darío Puchán , Josse Pierre , Mutovska Monika G. , Siegler Benjamin , Allain Magali , Morice Korentin , Blanchard Philippe , Gohier Frédéric , Le Bahers Tangui , Monnereau Cyrille , Zagranyarski Yulian , Lungerich Dominik , Cabanetos Clément 
Published: November 2023

AbstractWhile benzothioxanthene imide (BTI) has shown promise in organic electronics and more recently in photodynamic therapy, its full potential remains yet undiscovered. In this context, this study repots the synthesis and characterization of aza derivatives in which the characteristic sulfur atom is replaced by an amino group. Adapted from the synthetic route of the BTI, a way was found to control the electronic structure of the radical intermediates, by means of a simple chemical modification. As a result, either the thermodynamically six‐membered or the kinetically favored five‐membered ring regioisomers can selectively be accessed. Photophysical rationalization of their structure‐property relationships confirmed the richness, versatility and tunability of this class of rylene imide‐based dyes.