bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionalized MXene Ink Enables Environmentally Stable Printed Electronics
Authors: Park Soo-Jin , Ko Tae Yun , Ye Heqing , Murali G. , Lee Seul-Yi , Park Young Ho , Lee Jihoon , Lee Juyun , Yun Dong-Jin , Gogotsi Yury , Kim Seon Joon , Kim Se , Jeong Yong Jin , In Insik 
Published: October 2023

Abstract

Establishing dependable, cost-effective electrical connections is vital for enhancing device performance and shrinking electronic circuits. MXenes, renowned for their remarkable electrical conductivity and high breakdown voltage offer great promise as contact materials in microelectronics. However, their hydrophilic surfaces, susceptible to environmental degradation, and poor stability in organic solvents, have restricted their electronic applications. Thus, we’ve harnessed the electrohydrodynamic (EHD) printing for fully solution-processed thin-film transistors (TFTs). These TFTs employ alkylated 3,4-dihydroxy-L-phenylalanine functionalized Ti3C2Tx (AD-MXene) as source, drain, and gate electrodes. AD-MXene excels in EHD printing due to its outstanding dispersion stability in ethanol and sustained high electrical conductivity, surpassing traditional vacuum-deposited gold and aluminum electrodes. It enhances the environmental stability of TFTs, enabling integration into complex systems such as engineering logic gates (NOT, NAND, and NOR) and one-transistor-one-memory cells. This advance highlights ligand-functionalized MXenes’ significant potential in printed electrical contacts and paves the way for environmentally robust MXene-based electronics (MXetronics).
Pushing the thinness and transparency limit of silver films for flexible optoelectronic devices via an ion-beam thinning-back process
Authors: Duan Huigao , Ma Dongxu , Ji Ming , Yi Hongbo , Fan Fu , Feng Bo , Chen Yiqin 
Published: October 2023

Abstract
Silver (Ag) films thinner than 10 nm are ideal candidates for transparent conductors for flexible optoelectronic devices due to their merits of a low sheet resistance (Rs), high transparency and excellent flexibility performance. Further reducing the Ag film thickness theoretically allows higher transparency but in practice leads to reduced transparency and drastically increased sheet resistance because the ultrathin film tends to be noncontinuous and unsmooth. Herein, we developed a thinning-back process to address this dilemma, in which Ag film is first deposited to a larger thickness with high continuity and then thinned back to a reduced thickness with an ultrasmooth surface, both implemented by a flood ion beam. Contributed by the slight implantation of silver atoms into the substrate during the ion-beam sputtering deposition process, high-quality Ag films with a thinned thickness down to 4.5 nm can be obtained with atomic-level surface roughness due to the implantation-induced pinning effect. Enabled by the reduced thickness, high continuity and improved smoothness, the obtained ultrathin Ag films exhibit excellent visible transparency and comparable electrical conductivity to commercial indium tin oxide (ITO). Especially, the ultrasmooth surface allows the lowest optical haze among all existing transparent conductors. As a flexible transparent conductor, the ultrathin Ag films demonstrate outstanding mechanical flexibility due to the ductility of Ag metal. Considering the overall performance of the obtained ultrathin Ag films, this ion-beam-based process presents a promising solution towards the best possible transparent conductor with ultimate thinness and transparency for flexible optoelectronic devices.
Weather forecast using WRFg at 2 km resolution over two provinces in northwestern Panama
Authors: Batista Josue , Pinzon Reinhardt 
Published: October 2023

Abstract
In this paper, the 24- and 48-hour precipitation and temperature forecasts generated by dynamic downscaling (DDS) using the WRF-ARW (running on CPU) and AceCAST (running on GPU) models are analyzed for the western region of Panama (particularly in the provinces of Bocas del Toro and Chiriquí) during hurricanes ETA and IOTA. Various microphysics and cumulus parameterization schemes are used to generate rainfall forecasts with 11 and 2 km resolution, then these forecasts are compared against measurements from weather stations. The results indicate that under the ETA and IOTA events, the rainfall generated by BMJ microphysics scheme and Kain-Fritsch cumulus parameterization was the most similar to the observed rainfall data. On the other hand, it was found that the computation time of the forecasts obtained by AceCAST (GPU) was at least two times shorter than the WRF-ARW (CPU) model, thus using the computing power of GPUs to generate weather forecasts significantly reduces the issuance time of forecasts.
Simultaneous Learning against to Sequential Learning via Haptic Interaction
Authors: Saracbasi Ozge Ozlem , Harwin William , Kondo Toshiyuki , Hayashi Yoshikatsu 
Published: October 2023

Abstract

From a parent assisting to their child to use a spoon, to a physical therapist helping stroke patients to relearn walking, haptic assistance via haptic feedback plays an important role in skill learning. It is known that skill learning is associated with learning unknown dynamics within the interaction. For instance, while learning skills with a new partner under unknown environmental dynamics, humans are specifically exposed to two unknown dynamics: partner dynamics and environmental dynamics. Although recent studies have focused on skill learning mostly through adaptation to environmental dynamics or partner dynamics, much less is known about ’dual instability’. Is it possible to deal with dual instability? We developed a new paradigm in which we asked paired participants to control the joint cursor, representing the interaction dynamics e.g. partner, own self and environment. Note that the haptic device controls the joint cursor through two springs connected to cursors controlled by the paired participants, however, only the joint cursor was made visible. As the environmental dynamics exert the forces on the joint cursor, dual instability for the participants was realised. Under the cooperative task, we assessed whether one can learn to bring the joint cursor to the target with a partner. We examined skill learning under four conditions: (1) cooperative sequential learning, (2) simultaneous learning of partner and environmental dynamics, (3) individual sequential learning, (4) individual learning. Skill learning were quantified using time to target, trajectory smoothness and force. Experimental results suggested that if two-people interact actively (i.e. move the joint cursor together), there could be a separation of dual dynamics, which result in skill learning. The order of the unknown dynamics is not matter (e.g. sequential or simultaneous). There could be skill learning even though exposed to the most difficult condition, in simultaneous learning.
Mental Health App Boost My Mood (BMM) as Preventive Early Intervention for Adolescents With (Sub)clinical Depressive Symptoms
Authors: Willems Linda , Rasing Sanne P. A. , Heijs Dewi A. M. , Vermulst Ad A. , Huvenaars Mireille J. , Onrust Simone A. , Creemers Daan H. M. 
Published: October 2023

Abstract

Background
Depression is a common mental disorder. Detecting (sub)clinical depressive symptoms in adolescents at an early stage and offering a low-threshold early intervention can minimize the risk of serious and/or long-term depression. As such, a digital intervention can be a low-threshold preventive and early intervention. This study aims to examine whether the Boost My Mood (BMM)-app is a suitable preventive early intervention for adolescents with (sub)clinical depressive symptoms.
Methods
This naturalistic single-arm evaluation study (N = 50) was conducted in adolescents aged 16–21 with (sub)clinical depressive symptoms. Furthermore, the BMM-app was studied in relation to anxiety, worrying, stress, and sleeping problems. An exploratory objective was to determine whether positive expectations and social support are related to app use.
Results
The study showed a significant decrease in not only depressive symptoms, but also anxiety, worrying and stress while using the BMM-app. Sleeping problems did not significantly decrease over time while using the BMM-app. The degree of use of the BMM-app and telling significant others about using the BMM-app were both not related to a decrease in depressive symptoms. The BMM-app was used significantly more when the adolescent had told relatives about their depressive symptoms.
Conclusions
A digital intervention, such as the BMM-app, can be a low-threshold preventive and early intervention for adolescents with (sub)clinical depressive symptoms. Beneficial effects of the BMM-app were reported on depressive symptoms as well as other aspects of quality of life, such as anxiety, worrying, and stress. Whereas several factors may have played a role in the current findings on depressive symptoms, there are reasons to assume that part of the reduction in symptoms could be attributed to the BMM-app. Although no causality can be assumed, this study is a first step in the implementation of preventive apps in mental health care.
Adaptation of a standardized lifestyle intervention to maximize health outcomes in adolescent metabolic and bariatric surgery patients
Authors: Misserian Maral , Wheelington Alicia , King Rashon , Francis Jackson , Mathew M Sunil , Allicock Marlyn , Cartwright Bethany R. , Adewunmi Adejumoke , Chandrasekhar Aparajita , Polavarapu Dhatri , Barlow Sarah , Messiah Sarah E. 
Published: October 2023

Abstract
Background: Metabolic and bariatric surgery (MBS) is safe and efficacious in treating adolescents with severe obesity. Behavioral/lifestyle programs can support successful preparation for surgery and post-MBS weight loss, but no standardized lifestyle intervention exists for adolescents. Here we describe the process of developing and adapting the Diabetes Prevention Program Group Lifestyle Balance (DPP/GLB) curriculum to support adolescents pre- and post-MBS.
Methods: We collected both qualitative and quantitative data from a diverse group of adolescents (N=19, mean age 15.2 years, range 13-17, 76.0% female, 42.1% non-Hispanic Black, 42.1% non-Hispanic White, 15.8% Other, 59% Hispanic). Additionally, we included data from 13 parents, all of whom were mothers. These participants were recruited from an adolescent MBS program at Children’s Health System of Texas. In an online survey, we asked participants to rank their preferences and interests in DPP/GLB content topics. We complemented these results with in-depth interviews from a subset of 10 participants. This qualitative data triangulation informed the development of the TeenLYFT lifestyle intervention program, designed to support adolescents who were completing MBS. This program was adapted from the DPP/GLB, incorporating the social cognitive model (SCM) and the socioecological model (SEM) constructs to better cater to the needs of adolescent MBS patients.
Results: Adolescents’ top 3 ranked areas of content were: (1) steps to adopt better eating habits and healthier foods; (2) healthy ways to cope with stress; and (3) steps to stay motivated and manage self-defeating thoughts. Nearly all adolescent participants preferred online delivery of content (versus in-person). Mothers chose similar topics with the addition of information on eating healthy outside the home. Key themes from the adolescent qualitative interviews included familial support, body image and self-confidence, and comorbidities as key motivating factors in moving forward with MBS.
Conclusions: The feedback provided by both adolescents and parents informed the development of TeenLYFT, an online support intervention for adolescent MBS candidates. The adapted program may reinforce healthy behaviors and by involving parents, help create a supportive environment, increasing the likelihood of sustained behavior change. Understanding adolescent/parent needs to support weight management may also help healthcare providers improve long-term health outcomes for this patient population.
Down-regulated FDX1 inhibited the proliferation and migration of renal cell carcinoma cells
Authors: Bai Zhijie , Wang Chun , Zhang Mingpeng , Yang Yanjie , Liu Qian , Shang Zhiqun 
Published: October 2023

Abstract
Background
With the intensive study of cell death, a copper-related cell death mechanism has been uncovered that is different from other forms of cell death, which researchers have named cuproptosis. Ferredoxin1 (FDX1) is a key gene in cuproptosis. Available studies have shown that FDX1 expression is down-regulated in a variety of solid tumors and plays an inhibitory role in tumors. However, studies related to the role of FDX1 in renal cell carcinoma (RCC) and its mechanism are scarce and still need to be further explored.
Methods
Expression spectrum and clinical data obtained from TCGA were used to analyze the differential expression of FDX1 in various types of tumors, the relationship between FDX1 and different clinical features as well as patient survival and prognosis. Immunohistochemical staining experiments were used to verify the difference in FDX1 expression between RCC tissues and normal tissues. RT-qPCR and western blot were carried out to validate the expression of FDX1 between normal renal tubular epithelial cells and RCC cells at the mRNA and protein levels. The effects of FDX1 on the proliferation and migration ability of RCC cells were explored by CCK-8 and scratch assays. Finally, potential signaling pathways involved in FDX1 in RCC were analyzed via Gene Set Enrichment Analysis (GSEA)and subsequently validated using RT-qPCR.
Results
We found that FDX1 was lowly expressed in RCC tissues and cells, suggesting that FDX1 acts as a protective factor in RCC and that increased expression of FDX1 is favorable to the prognosis of patients. Tumor proliferation and invasive ability were inhibited after the expression of FDX1. In addition, GSEA analysis was significantly enriched in multiple signaling pathways including oxidative phosphorylation. RT-qPCR results indicated that the expression of some important genes in the oxidative phosphorylation pathway was also up-regulated after overexpression of FDX1 in RCC cells.
Conclusion
Low expression of FDX1 in RCC is associated with poor patient survival. Overexpression of FDX1 may be involved in inhibiting the proliferation and migration of RCC cells through the oxidative phosphorylation pathway.
New-Onset Atrial High-Rate Episodes in Left Bundle Branch Area Pacing Versus Right Ventricular Pacing for Patients With Atrioventricular Block
Authors: Zhang Shigeng , Yang Wen , Wang Shengchan , Cheng Yandi , Jiang Zhixin , zhou xiujuan , Shan qijun 
Published: October 2023

Abstract

Purpose
Left bundle branch area pacing (LBBAP) has demonstrated beneficial effects on clinical outcomes. Comparative data on the risk of atrial high-rate episodes (AHREs) between LBBAP and right ventricular pacing (RVP) are lacking. This study aimed to investigate whether LBBAP can reduce the risk of new-onset AHREs compared with RVP in patients with atrioventricular block (AVB).
Methods
A total of 175 consecutive AVB patients undergoing dual-chamber pacemaker implantation (LBBAP or RVP) and with no history of atrial fibrillation were enrolled. Propensity score matching for baseline characteristics yielded 43 matched pairs. The primary outcome was new-onset AHREs detected on scheduled device follow-up. Changes in echocardiographic measurements were also compared between groups.
Results
New-onset AHREs occurred in 42(24.0%) of all enrolled patients (follow-up 14.1 ± 7.5 months) and the incidence of new-onset AHREs in the LBBAP group was significantly lower than RVP (19.8% vs 34.7%, P = 0.039). After propensity score matching, LBBAP still resulted in significantly lower incidence of new-onset AHREs (11.6% vs 32.6%, P = 0.019), and a lower hazard ratio for new-onset AHREs compared with RVP (HR 0.274; 95% CI 0.113–0.692). At 1 year, LBBAP achieved preserved left ventricular ejection fraction (LVEF) (63.0 ± 3.2% to 63.1 ± 0.8%, P = 0.562), while RVP resulted in reduced LVEF (63.4 ± 4.9% to 60.5 ± 0.8%, P = 0.01). Changes in LVEF were significantly different between 2 groups {2.6% (0.2 to 5.0), P = 0.031}.
Conclusion
LBBAP demonstrated a reduced risk of new-onset AHREs compared with RVP in patients with AVB.
Non-invasive kidney diagnosis: A multimodal transformer system for diabetic nephropathy diagnosis via retinal imaging
Authors: Chen Xiangmei , Zheyi Dong , Wang Xiaofei , Pan Sai , Weng Taohan , Jiang Shuangshuang , Chen Xiao-Niao , Wang Qian , Li Ying , Wang Zonghua , Lin Wenwen , Li Liu , Jiang Lai , Li Shengxi , Deng Xin , Fu Yibing , Cheng Haimei , Cao Xueying , Yang Jian , Zhang Li , Yong Wang , Wu Jie , Tang Li , Chen Pu , Zhou Jianhui , Yu Xinyue , Yang Jin-Kui , He Yani , Lin Hong-Li , Geng Yanqiu , Li Jijun , Wang Liqiang , Xu Mai 
Published: October 2023

Abstract
It remains a formidable challenge to differentiate between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) without resorting to kidney biopsy, resulting in missed opportunities for targeted interventions that may significantly alter the prognosis of NDRD. To reform the traditional biopsy-all diagnostic paradigm and avoid unnecessary biopsy, we developed a transformer-based deep learning (DL) system for detecting DN and NDRD upon non-invasive multi-modal data of fundus images and clinical characteristics. Our Trans-MUF achieved an AUC of 0.980 (95% CI: 0.979 to 0.980) over the internal retrospective set, and also had the superior eneralizability over a prospective dataset (AUC: 0.989, 95% CI: 0.987 to 0.990) and a multicenter, cross-machine and multi-operator dataset (AUC: 0.932, 95% CI: 0.931 to 0.939). On the other hand, the accuracy of antidiastole detection by nephrologists can be improved by 21%, through visualization assistance of the DL system. Therefore, this paper lays a foundation for automatically differentiating DN and NDRD without biopsy.
Regulation of multi-condensates miscibility is required for limiting transgenerational epigenetic inheritance
Authors: Wan Gang , Zhao Changfeng , Cai Shiyu , Ruona shi , Yang Shuhan , Huang Jing , Liang Yonglin , Lu Pu , Zhang Xiaofei , Kennedy Scott 
Published: October 2023

Abstract

Biomolecular condensates, such as nucleolus, stress granules/P bodies, and germ granules in Caenorhabditis elegans, are multiphase assemblages. However, the mechanisms underlying the formation of these multi-phase condensates and their significance remain poorly understood. Here, we demonstrate that the spatially ordered PZMS assemblage of germ granules in Caenorhabditis elegans is established hierarchically by three LOTUS domain proteins. Additionally, we identified a Z granules protein termed HERD-1 that prevents the mixing of P granules, Z granules, and Mutator foci. Surprisingly, loss of herd-1 leads to RNAi defect but paradoxically results in prolonged transgenerational epigenetic inheritance of RNAi for over 50 generations due to uncontrolled pUG RNAs-siRNAs cycles after PZM fusion. Moreover, ectopic recruitment of Mutator foci to P granules or Z granules closely mimics the phenotype observed in herd-1mutant. Our findings propose an assembly principle for multi-phase condensates and highlight the active maintenance of immiscibility between condensates by specific cellular machinery, which restrict transgenerational epigenetic inheritance.
Validation of the ROX index to predict high flow nasal cannula therapy treatment failure in infants with bronchiolitis
Authors: Cloney Kellie , Stevens Hannah , Foster Jennifer , Gallant Julien , Sandila Navjot , Verma Neeraj , Krmpotic Kristina 
Published: October 2023

Abstract
Purpose
High-flow nasal cannula (HFNC) therapy is commonly used to provide an intermediate level of respiratory support for infants with bronchiolitis. The ratio of SpO2/FiO2 to respiratory rate (ROX index) has previously been shown to aid in prediction of HFNC treatment failure in adults and children with diverse respiratory diseases. We aimed to evaluate the utility of the ROX index in predicting HFNC treatment failure in infants with bronchiolitis.
Methods
Retrospective analysis of previously well infants (< 1 year) hospitalized for bronchiolitis and initiated on HFNC as their primary modality of respiratory support.
Results
Of 64 infants (median age 70 days), 5 (7.8%) required intubation within 6 hours of HFNC initiation (median time to intubation 225 minutes; interquartile range 125–290 minutes). No between-group differences were observed with respect to sex, age, weight, respiratory syncytial virus infection status, presumed bacterial pneumonia, hospital unit of HFNC initiation, or respiratory parameters at initiation and 1 hour following. Compared to infants who were successfully treated with HFNC, infants who required intubation were initiated earlier in the course of their illness (3 days vs 4 days; p = 0.02). The ROX index did not demonstrate discriminatory ability at time of HFNC initiation (AUROC 0.6; p = 0.5) or 1 hour after initiation (AUROC 0.6; p = 0.6).
Conclusions
The ROX index at HFNC initiation and 1 hour did not predict early treatment failure in infants with bronchiolitis. Examination of a larger cohort of infants and greater number of treatment failures is required.
Comparative clinical study of phosphorous-necrosis and medical-related osteonecrosis of the jaws
Authors: Xie Rongju , Wang Weihong , Bian Longchun , Qian Yemei , Li Jingyi , Zhang Hongrong 
Published: October 2023

Abstract
Background: Phosphorous necrosis of the jaw (PNJ) shares similar clinical and pathological features to medical-related osteonecrosis of the jaw (MRONJ). This study aims to compare the similarities and differences between PNJ and medical-related osteonecrosis of the jaw (MRONJ) in terms of clinical and pathological features, and to provide a theoretical basis for the clinical diagnosis and management of PNJ.
Material and Methods: A retrospective analysis assessed clinical differences among 38 PNJ patients and 31 MRONJ patients diagnosed and treated between January 2009 and October 2022. Pathological alterations in bone tissue were assessed using EDS, H&E, Masson and TRAP staining on five specimens from both MRONJ and PNJ cases, and immunohistochemistry was used to determine the expression levels of OPG, RANKL, and Runx2. The mandibular coronoid process was removed from individuals with temporomandibular joint ankylosis as control.
Results: CBCT imaging indicated necrotic bone formation in block, strip, or plaque shapes. EDS analysis revealed that the calcium/phosphorus ratio in the bone tissue of PNJ and MRONJ was significantly lower than that of the control group (P<0.05). Additionally, staining indicated reduced osteoblast counts, disrupted bone trabecular structure, and decreased collagen fiber content in the bone tissues of PNJ and MRONJ. Immunohistochemistry revealed that RANKL expression was significantly lower in MRONJ compared to PNJ and control groups (P<0.05). Conversely, Runx2 expression was significantly higher in PNJ than in MRONJ and control groups (P<0.05), with no significant difference in OPG expression.
Conclusion: PNJ and MRONJ exhibit comparable clinical manifestations and pathological traits, although disparities may exist in their underlyingexhibit comparable clinical manifestations and pathological traits, although disparities may exist in their underlying molecular mechanisms.