bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Open Trial and Mixed Methods Evaluation of Affirmative Dialectical Behaviour Therapy (DBT) Skills Training for Malaysian LGBT Adults
Authors: Keng Shian‐Ling , Liem Andrian , Ting Rachel Sing‐Kiat , Chung Ker Rou , Toh Yuhang , Chrisanne Shaleen , Wong Man Kuan , Seah T. H. Stanley 
Published: January 2025

ABSTRACTObjectivesLesbian, gay, bisexual and transgender (LGBT) individuals are at greater risk of mental health problems relative to cisgender heterosexual people. While various evidence‐based interventions exist to address the mental health needs of LGBT individuals, there is an urgent need to adapt these interventions to address stressors unique to the LGBT individual in the Global South, where LGBT identity remains highly stigmatised. This study developed and evaluated a six‐session affirmative dialectical behaviour therapy (DBT) skills group to address depressive symptoms in a sample of Malaysian LGBT adults.MethodsSeventeen LGBT adults (Mage = 26.9 years) with mild‐to‐severe levels of depressive symptoms were recruited from the community. Participants attended a DBT skills group for 6 weeks (2.5‐h/session). They completed self‐report measures on psychological symptoms, well‐being and minority stress at pre‐ and post‐intervention and a focus group discussion regarding their experience with the DBT skills group.ResultsSignificant decreases in depressive symptoms, stress, borderline personality disorder symptoms, emotion dysregulation and distress due to heterosexist experiences were observed from pre‐ to post‐intervention. There were also significant increases in self‐compassion and subjective well‐being. The number of DBT skills sessions attended was significantly associated with reductions in emotion dysregulation, internalised homophobia and distress due to heterosexist experiences. Thematic analyses of qualitative feedback revealed several helpful and challenging aspects of participating in the DBT skills group (e.g., time commitment, online format, and relevance and applicability of treatment content).ConclusionsThe study found that an LGBT‐affirmative DBT skills group is feasible and acceptable among Malaysian LGBT adults and shows promise in improving psychological health. These findings have implications for the adaptation of DBT skills training for marginalised populations in diverse, low‐resource contexts.
Pembrolizumab‐Induced Secondary Hypocorticism Manifesting as a Transitory Ischemic Attack
Authors: Finsterer Josef 
Published: January 2025

ABSTRACTPembrolizumab is a monoclonal antibody directed against the programmed cell death‐1 (PD1) receptor, which binds to PD1 receptors on T lymphocytes and blocks their inactivation by tumor cells. Pembrolizumab is not free from side effects, a rare one of which is hypocorticism. Here we present a patient with pembrolizumab‐induced hypocorticism manifested by a cerebrovascular event. The patient is a 67‐year‐old male with a history of urothelial carcinoma of the left kidney and urothelial carcinoma of the urinary bladder. These malignancies were treated with resection and adjuvant chemotherapy. Pembrolizumab was added 6 months before admission. After the fifth cycle, he suffered loss of appetite, persistent nausea and recurrent vomiting, an itchy rash, expressive aphasia for a few seconds during which he was suddenly unable to pronounce words and sentences, and massive positional vertigo due to arterial hypotension. His serum cortisol level was significantly low. Hypocorticism was successfully treated with hydrocortisone. This case demonstrates that pembrolizumab can be complicated by hypocorticism even after uneventful previous administration and that hypocorticism can manifest with symptomatic arterial hypotension, cerebral hypoperfusion, and positional vertigo. Treating physicians should be aware that secondary hypocorticism is a potentially serious adverse reaction due to the cumulative toxicity of pembrolizumab.
Automated Fault Detection and Reconfiguration in Five‐Level Hybrid Inverter for Enhanced System Resilience
Authors: Singh Vikram , Yadav Anamika , Gupta Shubhrata 
Published: January 2025

ABSTRACTThis paper introduces an efficient approach for the rapid detection and rectification of open circuit (OC) and short circuit (SC) switch faults in a single‐phase, five‐level hybrid multilevel inverter (HMLI). The HMLI system is equipped with both main and redundant units designed to address OC and SC faults. The main unit incorporates an active neutral point clamped (ANPC) leg and a half‐bridge leg, whereas the redundant unit consists of an H‐bridge. This setup provides multiple switching options for each voltage level, significantly improving fault reconfiguration (FR) capabilities under various fault conditions, including single, double, and triple switch faults, as well as varying utility conditions like changes in modulation index, load, and source. The system employs a data‐driven technique for fault detection that uses the inverter's voltage signal as raw data. The discrete Fourier (DF) is applied to convert this voltage signal into a fundamental frequency‐based signal, which is then used to determine the threshold for fault detection. Once a fault is detected, the system initiates the FR switching scheme to restore voltage levels, power, and efficiency to their pre‐fault state. Additionally, the proposed topology inherently achieves self‐voltage balancing in the DC link capacitor and operates with a single DC source configuration. Furthermore, a comprehensive and comparative analysis, including both experimental and simulation studies, is performed to evaluate the effectiveness and robustness of this topology.
Regulations ‘Under the Weather’: Legal Factors of Stability and Change for the Implementation of Natural Stormwater Management in Finland
Authors: Venuti Francesco , Heinilä Aleksi , Davids Peter R. 
Published: January 2025

ABSTRACTThe implementation of natural stormwater management (SWM), namely SWM carried out through nature‐based solutions (NBS), is still problematic despite their benefits in climate change adaptation. Private landownership is commonly cited as the factor limiting extensive NBS. However, the Finnish model demonstrates that, regardless of whether the needed land is private or public, implementing actors face numerous legal challenges in efforts to carry out SWM using NBS. We study the Finnish SWM and land use planning frameworks to uncover the legal barriers to and drivers of NBS implementation as well as the interaction of the frameworks with the wider governance setting. By doing so, we highlight the need for a regulatory approach to NBS that will facilitate their uptake. We first explore how the Finnish legal framework regulates natural SWM. Secondly, we use the policy arrangement approach (PAA) and the framework on stability and change in flood risk management to combine the results of the legal analysis with the findings from a series of interviews with urban planners from several Finnish municipalities. This in turn enables us to visualise how the law interacts with the broader governance system to limit and shape the options for implementing natural SWM. The main factors of stability (namely, keeping the status quo) for NBS include the lack of regulations and unclear and fragmented SWM responsibilities. The main factors encouraging change include cities' acquisition or ownership of public land, an integrated governance approach to SWM, the Green Area Factor (GAF), pilot projects and stormwater working groups.
Double Fortified Salt Containing Iodine and Folic Acid and Triple Fortified Salt Containing Iodine, Folic Acid, and Vitamin B12 Are Acceptable to Ethiopian Women of Reproductive Age
Authors: Tesfaye Biniyam , Tessema Masresha , Arnold Charles D. , Kebebe Tadesse , Zeru Tesfaye , Assefa Teshome , Woldeyohannes Meseret , Tollera Getachew , Koning Marinus , Martinez Homero , McDonald Christine M. , Brown Kenneth H. 
Published: January 2025

ABSTRACTRecognizing the broader accessibility of iodized salt compared to wheat flour, the Ethiopian government is considering fortification of iodized salt with folic acid, and possibly vitamin B12, to address the high incidence of neural tube defects (NTDs) in Ethiopia. To prepare for this program, we assessed practices related to edible salt procurement and consumption, and the acceptability of novel salts fortified with iodine and folic acid (double‐fortified salt, DFS) or iodine, folic acid, and vitamin B12 (triple‐fortified salt, TFS) compared to iodized salt (IS). We surveyed 840 women of reproductive age in urban (Addis Ababa) and rural (Gimbichu Woreda) areas to describe their salt preferences and practices and used a three‐point hedonic scale to evaluate the sensory acceptability of fine and coarse forms of DFS, TFS, and IS for color, taste, aroma, texture and overall acceptability. We found that women were the primary salt purchasers (72.8% rural, 97.4% urban) for household. Rural women preferred coarse salt (76.1%), whereas urban women preferred fine salt (42.4%) or both types (30.0%). All salts received favorable mean sensory ratings (≥ 2.1), with fine salt preferred for all sensory characteristics (p < 0.05). Fine IS (2.8 ± 0.5) was rated slightly higher than DFS (2.6 ± 0.8) and TFS (2.5 ± 0.8) (p < 0.05). Rural women were more willing to purchase DFS (79.2%) and TFS (73.0%) than urban women (65.0% DFS, 63.8% TFS). In conclusion, DFS and TFS are highly acceptable in Ethiopia, with women being the key target for their introduction. Mandatory fortification of both coarse and fine salts is recommended to maximize reach.
Web of Science‐Based Visualization of Metabolic Dysfunction‐Associated Fatty Liver Disease in Pediatric and Adolescent Populations: A Bibliometric Study
Authors: Hu Liangyu , Du Huarong , Zhou QianQian , Liu Chunlei , Zhang Tiansong , Yuan Min 
Published: January 2025

ABSTRACTBackground and AimsThe prevalence of metabolism‐associated fatty liver disease (MAFLD) in children is on the rise. This study employs visualization and analysis to evaluate the research implications, current advancements, and emerging trends in pediatric MAFLD, with the aim of elucidating its pathogenesis and informing the development of clinical treatment strategies.MethodsUsing visualization software, we conducted a visual analysis and mapping of the journal distribution, leading institutions, prominent authors, annual publication trends, and keyword frequencies among the 1179 scholarly articles retrieved from the Web of Science Core Collection for this study.ResultsThe overall publication volume demonstrated an upward trend, with a total of 200 journals, contributions from 63 countries, 882 research institutions, and 5605 authors involved, including 84 who were identified as core authors. The main research team is led by Nobili, Valerio. The main research institutions are concentrated in Italy, the United States, and China. A total of 473 keywords were included, and the keywords with high frequency and medium centricity are insulin resistance, metabolic syndrome, children, steatohepatitis, adolescents, hepatic steatosis, nash, obesity, diagnosis, and fibrosis, which resulted in six keyword clusters.ConclusionMAFLD represents a significant public health concern. Research on children and adolescents with MAFLD continues to attract high interest. Noninvasive diagnostic methods, pathogenesis (intestinal microbiota research), disease prediction (gene research) are current research hotspots.
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
Authors: Perner Florian , Gadrey Jayant Y. , Armstrong Scott A. , Kühn Michael W. M. 
Published: January 2025

AbstractChromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of translocation partners. The most frequently found fusion partners of KMT2A in acute leukemia are the C‐terminal parts of AFF1, MLLT3, MLLT1 and MLLT10. Unfortunately, the presence of an KMT2A‐rearrangements is associated with adverse outcomes in leukemia patients. Moreover, non‐rearranged KMT2A‐complexes have been demonstrated to be crucial for disease development and maintenance in NPM1‐mutated and NUP98‐rearranged leukemia, expanding the spectrum of genetic disease subtypes that are dependent on KMT2A. Recent advances in the development of targeted therapy strategies to disrupt the function of KMT2A‐complexes in leukemia have led to the establishment of Menin–KMT2A interaction inhibitors that effectively eradicate leukemia in preclinical model systems and show favorable tolerability and significant efficacy in early‐phase clinical trials. Indeed, one Menin inhibitor, Revumenib, was recently approved for the treatment of patients with relapsed or refractory KMT2A‐rearranged acute leukemia. However, single agent therapy can lead to resistance. In this Review article we summarize our current understanding about the biology of pathogenic KMT2A‐complex function in cancer, specifically leukemia, and give a systematic overview of lessons learned from recent clinical and preclinical studies using Menin inhibitors.
The correlation between ANAs and pregnancy loss and their impact on IVF/ICSI‐ET pregnancy outcomes in patients with recurrent pregnancy loss
Authors: Liu Manman , Zhang Hebo , Xu Shilian , Zhang Rui , Yuan Mengfan , Ren Bingnan , Zhang Wenjuan , Liu Zhaozhao , Guan Yichun 
Published: January 2025

AbstractObjectiveTo explore the correlation between antinuclear antibodies (ANAs) and pregnancy loss (PL), and to observe its impact on the pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection‐embryo transfer (IVF/ICSI‐ET) in recurrent PL (RPL) patients.MethodsIn this retrospective study, patients first seen at the hospital between January 2016 and December 2022 and who underwent two ANA tests within 4–6 weeks were included. After exclusion of confounding factors, patients were allocated to the non‐pregnancy loss (non‐PL), single‐PL, or RPL group according to previous number of PLs, and the correlation between PL and ANAs was analyzed. The first embryo transfer (ET) after in vitro IVF/ICSI without immunological treatment was placed in the RPL group, and patients were classified into the ANA‐negative or ANA‐positive subgroup according to ANA titer. The effect of ANAs on pregnancy outcomes in the RPL patients after IVF/ICSI‐ET was further analyze.ResultsThe results of multivariate unordered logistic regression showed that when the non‐PL group was used as the reference, ANA positivity was an independent risk factor for RPL (P = 0.023) but not for single PL (P = 0.654). When the single‐PL group was used as the reference, ANA positivity was an independent risk factor for RPL (P = 0.022). Multivariate logistic regression analysis revealed that the early PL rate of the ANA‐positive subgroup was significantly higher than that of the ANA‐negative subgroup (P = 0.009), and the total PL rate of the ANA‐positive subgroup was significantly higher than that of the ANA‐negative subgroup (P = 0.049).ConclusionThe results showed that ANA positivity may be related to RPL occurrence, but there was no significant correlation between ANA positivity and single PL. ANA positivity is associated with PL occurrence in RPL patients after transfer, and the correlation is reflected mainly in the first trimester.
Projector‐Based Quantum Embedding Study of Iron Complexes
Authors: Waldrop Jonathan M. , Panyala Ajay , Mejia‐Rodriguez Daniel , Windus Theresa L. , Govind Niranjan 
Published: January 2025

ABSTRACTProjection‐based embedding theory (PBET) is used to calculate and assess the challenging spin‐crossover energies for a selection of small Fe‐containing systems by embedding the metal center into the frozen potential of the ligands. MP2, CCSD, and CCSD(T) are embedded in potentials from the SCAN and r2SCAN functionals and compared with the canonical values for the constituent methods and previously reported reference values. Considering the PBET calculations as a correction for the underlying DFT, the embedding calculations are able to provided improvement for most cases. In some cases, the PBET methods are able to compensate for limitations in the wave function methods and produce results similar to more rigorous calculations from the literature. For the systems with spin‐crossover energies near zero, the current methodology fails to provide consistent improvement. The isolated recalculation of the electronic structure around the metal center when embedded into a DFT treatment of the ligand field shows promise as a pragmatic and lower cost treatment compared to the canonical treatment of the whole system of the difficult class of spin‐crossover complexes.
An ultrasensitive chemosensor based on Pb(II) complex of a xanthene ligand as an easily commercially available dye for the detection of cysteine in biological samples
Authors: Moalemian Mehdi , Tavallali Hossein , Khazali Fereydoon , Hosseini Mina 
Published: January 2025

AbstractIn this study, an ultra‐sensitive colorimetric chemosensor was designed and built for the identification and determination of Pb2+ and cysteine (Cys) by optical color variation based on indicator displacement evaluation (IDA) using xanthine, bromopyrogallol red (BPR) dye. Label exchange between BPR and Cys occurred when Cys was added to the lead(II) complex (BPR), resulting in a clear and immediate color variation from red to purple in a DMSO/MES buffer (10.0 mmol/L, pH 5.5 (1:4 v/v)). The suggested method shows a detection limit of 5.0 nmol/L and a good linear range of 0.04–4.71 μmol/L for cysteine. Moreover, based on the produced absorbance and color variation, this chemosensor is suggested as an “IMPLICATION” logic gate discussing Pb2+ and cysteine as input. As an application in molecular devices, based on such a fast and repeatable signal, a molecular‐scale sequential memory unit has been designed to exhibit “keypad lock” behavior. The expanded receptor provides satisfactory reproducibility, good precision, and is used for selective determination of Cys in human blood plasma and urine. In addition, the procedure's precision was compared with the results of the suggested procedure with the HPLC method.
Fast and efficient preparation of a carbonaceous catalyst from the rice husk under microwave irradiation for the conversion of xylose into furfural
Authors: Doan Vinh Thanh Chau , Nguyen Nhung Tuyet Thi , Le Thinh An Tan , Tran Phuong Hoang 
Published: January 2025

AbstractBACKGROUNDFurfural is an important platform compound obtained through the dehydration of xylose, a key component of lignocellulosic biomass. Carbonaceous catalysts for this conversion have received rising interest due to low‐cost price and easy modification. Rice husk is an abundant agricultural waste that could be employed as a carbon source for the preparation of many carbon materials, especially through green methods.RESULTSA carbonaceous catalyst (RH‐SO₃H) derived from rice husk through microwave (MW)‐assisted carbonization and sulfonation was employed as the catalyst for the conversion of xylose to furfural in dimethyl sulfoxide (DMSO). Fourier transform infrared (FT‐IR) spectroscopy results indicated that RH‐SO3H had typical signals of Brønsted acid groups while other characteristics were examined through other techniques, namely X‐ray diffraction (XRD), energy‐dispersive X‐ray (EDX) spectroscopy, Raman spectroscopy, scanning electron microscopy (SEM), and elemental mapping. Through many investigations, the furfural yields were impacted by the nature of solvents, substrate concentrations, catalyst dosages, reaction temperatures, and reaction time. A furfural yield of 60.3% was obtained at 160 °C for 8 h. The catalyst recyclability and the scalability ability of the procedure were examined, and a mechanism was also proposed.CONCLUSIONRice husk could be used as a starting source to prepare a carbon material via a MW‐irradiated protocol. The conversion of xylose to furfural under the catalysis of RH‐SO3H was easily operated, and the desired product was obtained in good yield. The crucial advantages of the current process are environmentally friendly, inexpensive, simple, and highly large‐scale application. The findings pave the way for eco‐friendly industrial applications, promoting circular economy principles and reducing reliance on non‐renewable resources in platform chemical production. © 2025 Society of Chemical Industry (SCI).
Deep Learning‐Assisted Computer‐Aided Diagnosis System for Early Detection of Lung Cancer
Authors: Lisha R. , Agees Kumar C. , Ajith Bosco Raj T. 
Published: January 2025

ABSTRACTPurposeThe largest cause of cancer‐related fatalities worldwide is lung cancer. The dimensions and positioning of the primary tumor, the presence of lesions, the type of lung cancer like malignant or benign, and the good mental health diagnosis all play a part in the diagnosis of the disease.MethodsThree processes should be used by standard computer‐assisted diagnosis (CAD) systems to detect lung cancer: preprocessing, feature extraction, and classification. Fast nonlocal means filter is first used for preprocessing (FNLM). The lung pictures are processed using the Binary Grasshopper Optimization Algorithm (BGOA) to extract the features.ResultsThe 10 levels of the neural network architecture which automatically gathers data and categorizes them are added to the current study's suggested model, which subtracts the five levels of Imagenet. Using the same Modèle dataset, the proposed model was compared to deep learning techniques.ConclusionIn terms of accuracy and sensitivity, the suggested model performed better than the existing techniques (99.53% accuracy and 98.95% sensitivity). The effectiveness of the suggested strategy is superior to that of alternative methods when it is near the true positive values at the ROC curve.
Navigating Nature's Terrain: Jumping Performance Robust to Substrate Moisture and Roughness by Blackspotted Rockskippers (Entomacrodus striatus)
Authors: Bartlett Daniel T. , Raffle Kaylin O. , Pettit Hayley N. , Brainard Miranda K. , Houglan Paityn M. , Gamel Kaelyn , Nopper Zachary O. , Harden Rebekah K. , Garner Austin M. , Londraville Richard L. , Astley Henry C. 
Published: January 2025

ABSTRACTEscape responses are vital for the survival of prey. The high speeds and accelerations needed to evade predators successfully require exerting forces on the environment. Unlike water, terrestrial habitats can vary in ways that constrain the forces applied, requiring animals to adjust their behavior in response to variable conditions. We evaluated the terrestrial jumping of an amphibious fish, the blackspotted rockskipper (Entomacrodus striatus), to determine if substrate roughness and wetness influence jumping performance. We predicted that rockskippers would produce a greater force output as substrate roughness increased and wetness decreased. Using a novel waterproof force plate capable of detecting millinewton loads, we collected ground reaction forces from rockskippers jumping on wet and dry sandpapers of varying grits. We also used micro‐CT scans to quantify muscle mass as a relative fraction of body mass to determine if these jumps could be performed without power amplification. Mixed‐model analysis of jumps revealed significantly higher maximum horizontal forces, jump duration, and maximum power on dry versus wet substrates, but no effect of substrate roughness. However, the final jump outcomes (takeoff speed and angle) were unaffected. Peak jump power was within the range of typical fish muscle. Thus, these fish display a jumping behavior which is robust to substrate property variation.