bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Neuroprotective Strategies: Unraveling the Potential of HDAC Inhibitors in Traumatic Brain Injury Management
Authors: Ye Lisha , Li Wenfeng , Tang Xiaoyan , Xu Ting , Wang Guohua 
Published: January 2024

:
Traumatic brain injury (TBI) is a significant global health problem, leading to high rates of
mortality and disability. It occurs when an external force damages the brain, causing immediate harm
and triggering further pathological processes that exacerbate the condition. Despite its widespread impact, the underlying mechanisms of TBI remain poorly understood, and there are no specific pharmacological treatments available. This creates an urgent need for new, effective neuroprotective drugs
and strategies tailored to the diverse needs of TBI patients. In the realm of gene expression regulation,
chromatin acetylation plays a pivotal role. This process is controlled by two classes of enzymes: histone acetyltransferase (HAT) and histone deacetylase (HDAC). These enzymes modify lysine residues
on histone proteins, thereby determining the acetylation status of chromatin. HDACs, in particular, are
involved in the epigenetic regulation of gene expression in TBI. Recent research has highlighted the
potential of HDAC inhibitors (HDACIs) as promising neuroprotective agents. These compounds have
shown encouraging results in animal models of various neurodegenerative diseases. HDACIs offer
multiple avenues for TBI management: they mitigate the neuroinflammatory response, alleviate oxidative stress, inhibit neuronal apoptosis, and promote neurogenesis and axonal regeneration. Additionally, they reduce glial activation, which is associated with TBI-induced neuroinflammation. This review
aims to provide a comprehensive overview of the roles and mechanisms of HDACs in TBI and to
evaluate the therapeutic potential of HDACIs. By summarizing current knowledge and emphasizing
the neuroregenerative capabilities of HDACIs, this review seeks to advance TBI management and contribute to the development of targeted treatments.
Occupational Therapy Students’ Evidence-Based Practice Skills as Reported in a Mobile App: Cross-Sectional Study
Authors: Johnson Susanne G , Espehaug Birgitte , Larun Lillebeth , Ciliska Donna , Olsen Nina Rydland 
Published: January 2024

Background
Evidence-based practice (EBP) is an important aspect of the health care education curriculum. EBP involves following the 5 EBP steps: ask, assess, appraise, apply, and audit. These 5 steps reflect the suggested core competencies covered in teaching and learning programs to support future health care professionals applying EBP. When implementing EBP teaching, assessing outcomes by documenting the student’s performance and skills is relevant. This can be done using mobile devices.

Objective
The aim of this study was to assess occupational therapy students’ EBP skills as reported in a mobile app.

Methods
We applied a cross-sectional design. Descriptive statistics were used to present frequencies, percentages, means, and ranges of data regarding EBP skills found in the EBPsteps app. Associations between students’ ability to formulate the Population, Intervention, Comparison, and Outcome/Population, Interest, and Context (PICO/PICo) elements and identifying relevant research evidence were analyzed with the chi-square test.

Results
Of 4 cohorts with 150 students, 119 (79.3%) students used the app and produced 240 critically appraised topics (CATs) in the app. The EBP steps “ask,” “assess,” and “appraise” were often correctly performed. The clinical question was formulated correctly in 53.3% (128/240) of the CATs, and students identified research evidence in 81.2% (195/240) of the CATs. Critical appraisal checklists were used in 81.2% (195/240) of the CATs, and most of these checklists were assessed as relevant for the type of research evidence identified (165/195, 84.6%). The least frequently correctly reported steps were “apply” and “audit.” In 39.6% (95/240) of the CATs, it was reported that research evidence was applied. Only 61% (58/95) of these CATs described how the research was applied to clinical practice. Evaluation of practice changes was reported in 38.8% (93/240) of the CATs. However, details about practice changes were lacking in all these CATs. A positive association was found between correctly reporting the "population" and "interventions/interest" elements of the PICO/PICo and identifying research evidence (P<.001).

Conclusions
We assessed the students’ EBP skills based on how they documented following the EBP steps in the EBPsteps app, and our results showed variations in how well the students mastered the steps. “Apply” and “audit” were the most difficult EBP steps for the students to perform, and this finding has implications and gives directions for further development of the app and educational instruction in EBP. The EBPsteps app is a new and relevant app for students to learn and practice EBP, and it can be used to assess students’ EBP skills objectively.
Exploring the Types of Social Support Exchanged by Survivors of Pediatric Stroke and Their Families in an Online Peer Support Community: Qualitative Thematic Analysis
Authors: Wright William J A , Howdle Charlotte , Coulson Neil S , De Simoni Anna 
Published: January 2024

Background
Pediatric stroke is relatively rare and underresearched, and there is little awareness of its occurrence in wider society. There is a paucity of literature on the effectiveness of interventions to improve rehabilitation and the services available to survivors. Access to online health communities through the internet may be a means of support for patients with pediatric stroke and their families during recovery; however, little research has been done in this area.

Objective
This study aims to identify the types of social support provided by an online peer support group to survivors of pediatric stroke and their families.

Methods
This was a qualitative thematic analysis of posts from a pediatric stroke population on a UK online stroke community active between 2004 and 2011. The population was split into 2 groups based on whether stroke survivors were aged ≤18 years or aged >18 years at the time of posting. The posts were read by 2 authors who used the adapted Social Support Behavior Code to analyze the types of social support exchanged.

Results
A total of 52 participants who experienced a pediatric stroke were identified, who posted a total of 425 messages to the community. About 41 survivors were aged ≤18 years at the time of posting and were written about by others (31/35 were mothers), while 11 were aged >18 years and were writing about themselves. Survivors and their families joined together in discussion threads. Support was offered and received by all participants, regardless of age. Of all 425 posts, 193 (45.4%) contained at least 1 instance of social support. All 5 types of social support were identified: informational, emotional, network, esteem support, and tangible aid. Informational and emotional support were most commonly exchanged. Emotional support was offered more often than informational support among participants aged ≤18 years at the time of posting; this finding was reversed in the group aged >18 years. Network support and esteem support were less commonly exchanged. Notably, the access subcategory of network support was not exchanged with the community. Tangible aid was the least commonly offered type of support. The exchanged social support provided insight into rehabilitation interventions and the unmet needs of pediatric stroke survivors.

Conclusions
We found evidence of engagement of childhood stroke survivors and their families in an online stroke community, with peer support being exchanged between both long- and short-term survivors of pediatric stroke. Engagement of long-term survivors of pediatric stroke through the online community was key, as they were able to offer informational support from lived experience. Further interventional research is needed to assess health and rehabilitation outcomes from engagement with online support groups. Research is also needed to ensure safe, nurturing online communities.
Global Trends in the Incidence of Anxiety Disorders From 1990 to 2019: Joinpoint and Age-Period-Cohort Analysis Study
Authors: Cao Huiru , Wu Yang , Yin Hui , Sun Yanqi , Yuan Hui , Tao Mengjun 
Published: January 2024

Background
Anxiety disorders (ADs) are the most common mental illness with high prevalence, chronicity, and comorbidity. Despite rapid economic and cultural development, the global incidence of ADs continues to increase, with predominance in male individuals.

Objective
To address the above issues, we analyzed the dynamic trends of the global incidence and disease burden of ADs from 1990 to 2019 and their different effects on age, period, and birth cohort and predicted the future trend of AD incidence.

Methods
The data were obtained from the Global Burden of Disease study in 2019. A joinpoint regression model was used to calculate the annual percent change in AD incidence, and age-period-cohort analysis was used to estimate the independent effects of age, period, and cohort. Nordpred age-period-cohort analysis was used to predict the incidence of ADs from 2020 to 2044.

Results
The age-standardized incidence rate of ADs increased by 1.06% for both sexes, and the age-standardized disability-adjusted life-year (DALY) rate (ASDR) decreased by 0.12%. Joinpoint regression indicated that increments in average annual percent changes in the age-standardized incidence rate (0.068 vs 0.012) and ASDR (0.035 vs –0.015) for ADs globally were higher among male individuals than female individuals. The age-period-cohort analyses revealed that the relative risk (RR) of the incidence and DALYs of ADs among people of different sexes increased with age in adolescence and middle age and then decreased. For the period effect, the RR of incidence decreased, whereas the RR of DALYs increased in both sexes. Moreover, the RR of the incidence gradually increased and DALYs slowly decreased with birth year for both male and female individuals. New cases of ADs in male individuals are predicted to increase in the coming 25 years.

Conclusions
This study provided the changing trend of the global incidence and disease burden of ADs in the past 3 decades, indicating that early prevention and effective control cannot be ignored. We analyzed the age-period-cohort effect of potential trends in ADs and predicted future incidence trends. The results suggest that we should take active intervention measures, focusing on high-risk groups and developing effective management and control policies to reduce the global burden of disease.
Evaluation of the Quality and Readability of Web-Based Information Regarding Foreign Bodies of the Ear, Nose, and Throat: Qualitative Content Analysis
Authors: Ko Tsz Ki , Tan Denise Jia Yun , Fan Ka Siu 
Published: January 2024

Background
Foreign body (FB) inhalation, ingestion, and insertion account for 11% of emergency admissions for ear, nose, and throat conditions. Children are disproportionately affected, and urgent intervention may be needed to maintain airway patency and prevent blood vessel occlusion. High-quality, readable online information could help reduce poor outcomes from FBs.

Objective
We aim to evaluate the quality and readability of available online health information relating to FBs.

Methods
In total, 6 search phrases were queried using the Google search engine. For each search term, the first 30 results were captured. Websites in the English language and displaying health information were included. The provider and country of origin were recorded. The modified 36-item Ensuring Quality Information for Patients tool was used to assess information quality. Readability was assessed using a combination of tools: Flesch Reading Ease score, Flesch-Kincaid Grade Level, Gunning-Fog Index, and Simple Measure of Gobbledygook.

Results
After the removal of duplicates, 73 websites were assessed, with the majority originating from the United States (n=46, 63%). Overall, the quality of the content was of moderate quality, with a median Ensuring Quality Information for Patients score of 21 (IQR 18-25, maximum 29) out of a maximum possible score of 36. Precautionary measures were not mentioned on 41% (n=30) of websites and 30% (n=22) did not identify disk batteries as a risky FB. Red flags necessitating urgent care were identified on 95% (n=69) of websites, with 89% (n=65) advising patients to seek medical attention and 38% (n=28) advising on safe FB removal. Readability scores (Flesch Reading Ease score=12.4, Flesch-Kincaid Grade Level=6.2, Gunning-Fog Index=6.5, and Simple Measure of Gobbledygook=5.9 years) showed most websites (56%) were below the recommended sixth-grade level.

Conclusions
The current quality and readability of information regarding FBs is inadequate. More than half of the websites were above the recommended sixth-grade reading level, and important information regarding high-risk FBs such as disk batteries and magnets was frequently excluded. Strategies should be developed to improve access to high-quality information that informs patients and parents about risks and when to seek medical help. Strategies to promote high-quality websites in search results also have the potential to improve outcomes.
Análisis sobre el debido proceso en la actuación de la autoridad aduanera colombiana sobre mercancías importadas.
Authors: Duque - Castaño Yeny Paola , Lukau - Quintero Claudia Elena 
Published: January 2024

Objetivo: Este artículo tiene como finalidad analizar el debido proceso en la actuación de la autoridad aduanera colombiana sobre las mercancías. Método: la investigación responde a un enfoque cualitativo, en la que se realiza una línea jurisprudencial mediante el análisis de sentencias emitidas por la Corte Constitucional y el Consejo de Estado. Resultados y discusión: Es claro que la autoridad aduanera colombiana, es competente para hacer control previo y posterior a la mercancía extranjera que ingresa al país, no obstante, el proceso y las condiciones para cada procedimiento no son claras, toda vez que, los importadores evidencian inconformidad frente a las actuaciones extemporáneas, dilación de procesos, actos administrativos emitidos por misma la entidad aduanera que vulnera el debido proceso, sobre todo en actuaciones de aprehensión y decomiso. Conclusiones: La Sentencia C 441 de 2021 emitida por la Corte Constitucional, determinó que el proceso que realiza la autoridad aduanera respecto al régimen sancionatorio no es acorde con el principio de reserva legal, toda vez que en materia sancionatoria quien tiene la potestad para regularla es el Congreso de la República, por lo tanto, otorgó como plazo máximo hasta el 20 de junio del año 2023 para expedir el régimen sancionatorio y de decomiso de mercancías en materia aduanera, así como el proceso administrativo aplicable.
Blog-Based Writing Instruction in Fostering EFL Writing Performance: Students’ Belief and Attitudes
Authors: St Hartina  , Nurhasanah Safei  , Nur Tahan Riani  
Published: January 2024

The existence of blogs offers an innovation that encourages a new writing style integrated with technology. However, it seems that there are still not many EFL writing classes in Indonesia using online blogs, and little research has been conducted on how students’ perception of a blog in writing. This study aims to analyze the Indonesian EFL learners' perceptions toward the use of Blog as the medium of learning practices in English Writing class. This study use qualitative research involving a questionnaire and semi-structured interviews were used. For 12 weeks, thirty-four students participated in this study by posting weekly entries from their English writing assignments on blogs. The data from the questionnaire reveals that the majority of students strongly agree and agree with the usefulness, effectiveness, attitudes, and practicality of using a blog in English writing class. It means that blog as learning media is very influential in the development of students' learning process. The interview result also showed that online blogging provided many advantages such as being easy to operate, writing can be accessed by all readers in the world, receiving and giving comments on friends' blogs, no longer needing to the stationary, and encouraging the student's creativity to write systematically.
Analysis of the Law Enforcement Practices in Regulating the Territorial Planning and Forming the Targeted Land Use Criteria
Authors: Tikhonova Kseniya V. , Burdova Darya V. , Penko Valeriya V. , Chirva Ekaterina A. 
Published: January 2024

The issues of the territorial planning legal regulation and territorial entities’ land resource potential application are studied, as well as the law enforcement practices of development and
validation of the territorial planning documents as a single legal and technical framework for deployment of the capital construction facilities and establishment of the appropriate legal land use regimes. Moreover, the problems of the territorial planning documents’ quality and possible ways to minimise their number or eliminate thereof are analysed. Thus, the necessity to optimise the Federal State Information System of Territorial Planning (FSIS TP) based on integrating the data of the Unified State Register of Real Property, the Urban Planning and Management Information System and other related information sources involved in the territorial planning is justified, which would enable accumulation and reflection of their structural components in a single geospatial system.
Implementation of the Artificial Intelligence Technologies in the Agribusiness: State of the Art and Prospects
Authors: Polyakov Vyacheslav V. 
Published: January 2024

The specific features of implementing the artificial intelligence technologies in the work of the agribusiness enterprises are studied. The main directions for using such technologies are distinguished,
the successful practices of implementing thereof in the work of the national enterprises are noted, and
the trends for supporting the above mentioned processes are analysed. The importance of the state
support aimed at enhancing accessibility of the AI-based technologies for the agribusiness sector is
substantiated.
Reformulasi Hubungan Kerja bagi Driver Online: Analisis Kekosongan Hukum untuk Mengkonstruksi Pekerjaan yang Layak
Authors: I Komang Dananjaya  , Ni Kadek Ayu Sri Undari  , I Made Halmadiningrat  
Published: January 2024

Nuansa eksploitatif dalam hubungan pekerjaan antara driver online dengan perusahaan penyedia layanan memunculkan diskursus penentuan klasifikasi hubungan hukum bagi para pihak. Penggunaan istilah “hubungan kemitraan” yang saat ini diterapkan tanpa dasar hukum yang jelas mengakibatkan perusahaan memiliki tendensi untuk memperoleh keuntungan yang tinggi tanpa memiliki kewajiban dalam pemenuhan terhadap hak-hak driver online sebagai pekerja. Situasi ini bertolak belakang dengan Sustainable Development Goals 2030 poin ke delapan yang menghendaki adanya perlindungan terhadap hak-hak pekerja sebagai salah satu indikator dalam menciptakan pekerjaan yang layak dan pertumbuhan ekonomi. Dalam menganalisa permasalahan hubungan pekerjaan antara driver online dengan penyedia layanan, penelitian ini menggunakan metode penelitian secara normatif dengan pendekatan perundang-undangan (statute approach), pendekatan konseptual (conceptual approach) dan pendekatan perbandingan (comparative approach). Hasil penelitian ini menunjukkan kedudukan hubungan kerja antara pekerja driver online dengan penyedia layanan sejatinya merupakan bentuk penyelundupan hukum yang mengatasnamakan hubungan kemitraan yang pada prakteknya menunjukkan (i) tidak sejalan dengan filosofi dari asas kebebasan berkontrak dan (ii) ketidakseimbangan kedudukan para pihak dalam perjanjian kemitraan. Padahal, apabila bersandar pada pertimbangan konsep hubungan tidak standar oleh International Labour Organization, interpretasi unsur hubungan kerja dan perbandingan dengan negara lain menunjukkan bahwa hubungan para pihak seharusnya dikategorikan sebagai jenis hubungan baru dalam sistem ketenagakerjaan Indonesia. Untuk itu, penelitian ini menawarkan konstruksi berkaitan dengan relasi kerja para pihak dalam peraturan perundang-undangan yang berusaha memproteksi driver online dari tendensi eksploitasi penyedia layanan. Hal tersebut mencakup pengupahan, Keselamatan dan Kesehatan Kerja (K3), hak istirahat, maupun hak cuti.

Kata Kunci: Ketenagakerjaan, Hubungan Kemitraan, Driver Online, Sustainable Development Goals
A PHYSIOTHERAPY MANAGEMENT IN ANKLE SPRAIN CASES USING TENS MODALITY AND EXERCISE THERAPY
Authors: Alfian Luthfi , Akbar Bota Muhammad , Khasanah AL Um Aniswatun 
Published: January 2024

ABSTRAKSprain ankle adalah gangguan muskuloskeletal penyebab oleh peregangan berlebihan atau robeknya ligament ankle. Dalam kebanyakan kasus terjadinya akibat keseleo lateral atau medial yang tiba-tiba yang merobek ligament ankle. Masalah lain yang menyebabkan sprain ankle adalah cedera yang dialami sebelumnya atau terbatasnya mobilitas pergelangan kaki. Transcutaneus Electrical Nerve Stimlation (TENS) digunakan pada penelitian ini.
TENS bekerja dengan cara merangsang pada serabut serabut saraf tipe α β sehingga bisa menurunkan rasa nyeri. Terapi lathan pada sprain ankle memiliki tujuan yang meliputi peningkatan kekuatan otot, stabilitas dan proprioception sendi, postur yang lebih baik, perbaikan gerakan berjalan, serta peningkatan fungsi secara keseluruhan.
Metode : Metode penelitian yaitu studi kasus untuk mengetahui penataksanaan fisioterapi pada kasus sprain ankle dengan modalitas TENS dan terapi latihan.Hasil : Penatalaksanaan proses fisioterapi selama 6 kali pertemuan dengan modalitas TENS dan terapi latihan pada pasien Sprain Ankle telah dilakukan dengan standar dengan oprasonal yang didapatkan hasil peningkatan stabilisasi, penurunan nyeri dan peningkatan aktivitas fungsional.Kesimpulan : Modalitas TENS dan terapi latihan pada pasien sprain ankle dapat meningkatkan stabilisasi, penurunan nyeri dan aktivitas fungsional pada pasien.
Kata Kunci : TENS, Sprain Ankle, Terapi Latihan
AI Chatbot for Tourist Recommendations: A Case Study in Vietnam
Authors: Nguyen Hai Thanh , Tran Thien Thanh , Nham Phat Tan , Nguyen Nhi Uyen Bui , Le Anh Duy 
Published: January 2024

Abstract
Living standards are rising due to a more developed society, and recreation, particularly tourism, is becoming more critical. Expanding the tourist industry is one of the most significant concerns in economic growth. Tourism revenue has helped increase residents’ income, leading to socio-economic development. In recent years, emerging Vietnamese tourism spots like Hon Son, Sapa, Hue, Phu Quoc in Vietnam, and others have consistently drawn travellers to visit and experience through social networking platforms. Tourism potential is tremendous, but foreign visitors’ information about tourist destinations still needs to be improved. This work proposes an approach to integrating machine learning algorithms into an information system to consult tourism traveling. Machine learning algorithms can classify question topics, predict user intent, and predict conversation scenarios to give appropriate responses. Our method is evaluated on the dataset, including 7319 samples on 11 topics collected from the TWCS dataset, using three algorithms: Bag of Words, BERT, and RoBERTa. BERT achieved the highest performance among the surveyed algorithms with 90 % in accuracy and 90.1 % in F1-Score. From the trained model, the team built a mobile application on Android to deploy the chatbot application with the Flutter framework based on Dart, an object-oriented programming language developed by Google using the concept of containers. The system’s functionality serves two primary user groups: administrators and application users. Administrators can utilize the application’s primary functions to manage content set up, and train a chatbot. Users can access information about locations, read location articles, check hotel prices, and use chatbots to find answers to their location-related questions. Administrators can also train the chatbot model to expand its knowledge.