bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural killer cell‐based signature: Prognostic analysis in head and neck squamous cell carcinoma
Authors: Guo Zizhao , Zhao Yuxia , Xu Meng , Zhao Long , Wang Xiaolei 
Published: February 2024

AbstractBackgroundHead and neck squamous cell carcinoma (HNSC) is a challenging cancer with significant clinical implications. Natural killer (NK) cells have emerged as important players in tumor immunosurveillance, yet their role and potential as prognostic biomarkers in HNSC remain unclear.MethodsQuantitative analysis using multiple algorithms identified FCRL1, KIR3DL2 and ZNF541 as molecules significantly associated with local NK cell infiltration and patient survival. A prognostic model based on these molecules demonstrated robust predictive performance.ResultsAnalysis of high‐ and low‐risk patient groups revealed distinct differences in the tumor microenvironment, indicating an inhibitory immune microenvironment in high‐risk patients. Notably, low‐risk patients exhibited potential sensitivity to immunotherapy and showed favorable responses to specific drugs such as axitinib, methotrexate, rapamycin and vorinostat. NK cells, important effectors of the innate immune response, were found to play a crucial role in HNSC immunity. The present study provides valuable insights into the correlation between FCRL1, KIR3DL2, ZNF541 and NK cell infiltration, paving the way for future investigations into their roles in HNSC. Activation of NOTCH signaling, MYC targets, DNA repair, E2F targets, epithelial–mesenchymal transition, G2M checkpoint and mitotic spindle pathways in high‐risk patients suggests their involvement in disease progression and poor prognosis.ConclusionsThe present study reveals the significance of NK cells in HNSC and their potential as prognostic biomarkers. The CFKZ score offers a promising approach for predicting patient outcomes and guiding personalized treatment decisions in HNSC. These findings contribute to our understanding of HNSC immunobiology and hold implications for precision medicine in HNSC management.
The principle of reciprocity in Scharff interviews
Authors: Palena Nicola , Granhag Pär‐Anders , Vrij Aldert , Orthey Robin , Monticciolo Roberto , Caso Letizia 
Published: February 2024

AbstractStudies on the collection of information (intelligence) show the effectiveness of the Scharff technique and the principle of reciprocity. These two aspects have never been considered at the same time. In the present experiment, we compared the effect of two different forms of reciprocity (intrinsic vs. instrumental) and their combination on the elicitation of information in Scharff interviews. Participants were asked to imagine that an interview took place and were exposed to four reciprocity conditions (no reciprocity, intrinsic reciprocity, instrumental reciprocity, intrinsic and instrumental reciprocity). The results showed that instrumental reciprocity resulted in more information than intrinsic reciprocity.
Role of isomers and steric hindrance in the micellization of carboxylated carbosilane surfactants
Authors: Wu Tianquan , Liu Hailong , Tan Jinglin 
Published: February 2024

AbstractA series of carboxylated carbosilane surfactants with methyl, ethyl, branching CH3, phenyl, and cyclohexyl (Me‐Si2C‐COONa, Et‐Si2C‐COONa, Si2C‐La‐COONa, Ph‐Si2C‐COONa, and Cy‐Si2C‐COONa) were prepared. The effect of isomer and steric hindrance on their micellization in aqueous solution was investigated by surface tension, conductivity, transmission electron microscopy (TEM) and dynamic light scattering (DLS). Si2C‐La‐COONa with branching CH3 shows a lower γCMC value and higher the CMC value compared with Et‐Si2C‐COONa. Cy‐Si2C‐COONa with cyclohexyl (41.6 mN m−1) and Ph‐Si2C‐COONa with phenyl (43.9 mN m−1) have larger γCMC values due to the distinct steric hindrance and hydrophobicity. In aqueous solution, the aggregation behavior of Si2C‐La‐COONa, Cy‐Si2C‐COONa, and Ph‐Si2C‐COONa is enthalpy‐driven. However, the micellization process of Me‐Si2C‐COONa and Et‐Si2C‐COONa is governed by the enthalpy‐driven at high temperature and entropy‐driven at low temperature. DLS and TEM results indicate that the carboxylated carbosilane surfactants can self‐assemble into aggregate with hydrodynamic diameters of 50–400 nm.
GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR‐200/ataxia telangiectasia mutated axis in diabetic wound healing
Authors: Liang Zun‐Hong , Lin Shi‐Shuai , Qiu Zhi‐Yang , Pan Yun‐Chuan , Pan Nan‐Fang , Liu Yun 
Published: February 2024

AbstractDiabetic foot ulcer (DFU) is a serious complication of diabetic patients which negatively affects their foot health. This study aimed to estimate the role and mechanism of the miR‐200 family in DNA damage of diabetic wound healing. Human foreskin fibroblasts (HFF‐1 cells) were stimulated with high glucose (HG). Db/db mice were utilized to conduct the DFU in vivo model. Cell viability was evaluated using 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide assays. Superoxide dismutase activity was determined using detection kits. Reactive oxygen species determination was conducted via dichlorodihydrofluorescein‐diacetate assays. Enzyme‐linked immunosorbent assay was used to evaluate 8‐oxo‐7,8‐dihydro‐2′deoxyguanosine levels. Genes and protein expression were analyzed by quantitative real‐time polymerase chain reaction, western blotting, or immunohistochemical analyses. Luciferase reporter gene and RNA immunoprecipitation assays determined the interaction with miR‐200a/b/c‐3p and GLI family zinc finger protein 2 (GLI2) or ataxia telangiectasia mutated (ATM) kinase. HG repressed cell proliferation and DNA damage repair, promoted miR‐200a/b/c‐3p expression, and suppressed ATM and GLI2. MiR‐200a/b/c‐3p inhibition ameliorated HG‐induced cell proliferation and DNA damage repair repression. MiR‐200a/b/c‐3p targeted ATM. Then, the silenced ATM reversed the miR‐200a/b/c‐3p inhibition‐mediated alleviative effects under HG. Next, GLI2 overexpression alleviated the HG‐induced cell proliferation and DNA damage repair inhibition via miR‐200a/b/c‐3p. MiR‐200a/b/c‐3p inhibition significantly promoted DNA damage repair and wound healing in DFU mice. GLI2 promoted cell proliferation and DNA damage repair by regulating the miR‐200/ATM axis to enhance diabetic wound healing in DFU.
Scaling up open access publishing through transformative agreements: Results from 2019 to 2022
Authors: Hoogendoorn Ciaran , Redvers‐Mutton Gaynor 
Published: February 2024

Key Points
The Biochemical Society's transformative Read & Publish (R&P) agreements follow an all‐inclusive and unlimited model (developed in collaboration with other society publishers) that cover all titles, both hybrid and fully open access (OA), and does not place caps on article numbers.
This case study shows that these R&P agreements have significantly boosted OA uptake in the United Kingdom, Australia and New Zealand.
It also shows that the agreements are most effective in regions where there is adequate funding, high research output and a willingness from institutions to engage collectively (through consortium agreements).
Where these conditions do not exist alternative models will be needed to complement R&P—in our case we plan to implement Subscribe to Open from 2025 onwards.
Generalized noncooperative Schrödinger–Kirchhoff–type systems in RN$\mathbb {R}^N$
Authors: Chems Eddine Nabil , Repovš Dušan D. 
Published: February 2024

AbstractWe consider a class of noncooperative Schrödinger–Kirchhof–type system, which involves a general variable exponent elliptic operator with critical growth. Under certain suitable conditions on the nonlinearities, we establish the existence of infinitely many solutions for the problem by using the limit index theory, a version of concentration–compactness principle for weighted‐variable exponent Sobolev spaces and the principle of symmetric criticality of Krawcewicz and Marzantowicz.
Preparation of Chladophora‐Based Biochar and Its Adsorption Properties for Antibiotics
Authors: Liu Luxing , Shang Dawei , Zhao Yang , Zhao Qun , Guo Yue , Zhang Fengrong , Kong Qiang , Zhang Huanxin , Wang Qian , Zhao Congcong 
Published: February 2024

AbstractThe biochar prepared by Chladophora (CB) was used to adsorb the ibuprofen and ofloxacin in sewage. SEM showed that CB preserved the natural tubular structure and increased its specific surface area. According to the BET results, the specific surface area of CB was 296.831 m2 g‐1. The adsorption of ibuprofen and ofloxacin on biochar conformed to the pseudo second‐order kinetic model, indicating that their adsorption rate was controlled by the chemical adsorption mechanism. According to the adsorption isotherms study, the adsorption of ibuprofen on CB met the Dubin‐Radushkevich model, while it fitted well with the Freundlich model for ofloxacin adsorption, making their adsorption onto biochar relating to non‐uniform surface and adsorption layer, respectively. The pore filling and electrostatic interaction were considered the main mechanism for the adsorption of pharmaceuticals and personal care products on CB, whereas the π‐π electron donor acceptor (EDA) interaction and hydrogen bond would also partially contribute to the adsorption process.
Amidation‐Reaction Strategy Constructs Versatile Mixed Matrix Composite Membranes towards Efficient Volatile Organic Compounds Adsorption and CO2 Separation
Authors: Li Boyu , Liu Xiaohui , He Xuanting , Liu Jiaxiang , Mao Shun , Tao Wenquan , Li Zhuo 
Published: February 2024

AbstractMixed matrix composite membranes (MMCMs) have shown advantages in reducing VOCs and CO2 emissions. Suitable composite layer, substrate, and good compatibility between the filler and the matrix in the composite layer are critical issues in designing MMCMs. This work develops a high‐performance UiO‐66‐NA@PDMS/MCE for VOCs adsorption and CO2 permea‐selectivity, based on a simple and facile fabrication of composite layer using amidation‐reaction approach on the substrate. The composite layer shows a continuous morphological appearance without interface voids. This outstanding compatibility interaction between UiO‐66‐NH2 and PDMS is confirmed by molecular simulations. The Si─O functional group and UiO‐66‐NH2 in the layer leads to improved VOCs adsorption via active sites, skeleton interaction, electrostatic interaction, and van der Waals force. The layer and ─CONH─ also facilitate CO2 transport. The MMCMs show strong four VOCs adsorption and high CO2 permeance of 276.5 GPU with a selectivity of 36.2. The existence of VOCs in UiO‐66‐NA@PDMS/MCE increases the polarity and fine‐tunes the pore size of UiO‐66‐NH2, improving the affinity towards CO2 and thus promoting the permea‐selectivity for CO2, which is further verified by GCMC and EMD methods. This work is expected to offer a facile composite layer manufacturing method for MMCMs with high VOC adsorption and CO2 permea‐selectivity.
Constructing Built‐In Electric Field in NiCo2O4‐CeO2 Heterostructures to Regulate Li2O2 Formation Routes at High Current Densities
Authors: Huang Renshu , Zhai Zhixiang , Chen Xingfa , Liang Xincheng , Yu Tianqi , Yang Yueyao , Li Bin , Yin Shibin 
Published: February 2024

AbstractDeveloping catalysts with suitable adsorption energy for oxygen‐containing intermediates and elucidating their internal structure‐performance relationships are essential for the commercialization of Li–O2 batteries (LOBs), especially under high current densities. Herein, NiCo2O4‐CeO2 heterostructure with a spontaneous built‐in electric field (BIEF) is designed and utilized as a cathode catalyst for LOBs at high current density. The driving mechanism of electron pumping/accumulation at heterointerface is studied via experiments and density functional theory (DFT) calculations, elucidating the growth mechanism of discharge products. The results show that BIEF induced by work function difference optimizes the affinity for LiO2 and promotes the formation of nano‐flocculent Li2O2, thus improving LOBs performance at high current density. Specifically, NiCo2O4‐CeO2 cathode exhibits a large discharge capacity (9546 mAh g−1 at 4000 mA g−1) and high stability (>430 cycles at 4000 mA g−1), which are better than the majority of previously reported metal‐based catalysts. This work provides a new method for tuning the nucleation and decomposition of Li2O2 and inspires the design of ideal catalysts for LOBs to operate at high current density.
Catalyzing Desolvation at Cathode‐Electrolyte Interface Enabling High‐Performance Magnesium‐Ion Batteries
Authors: Deng Rongrui , Lu Guanjie , Wang Zhongting , Tan Shuangshuang , Huang Xueting , Li Rong , Li Menghong , Wang Ronghua , Xu Chaohe , Huang Guangsheng , Wang Jingfeng , Zhou Xiaoyuan , Pan Fusheng 
Published: February 2024

AbstractMagnesium ion batteries (MIBs) are expected to be the promising candidates in the post‐lithium‐ion era with high safety, low cost and almost dendrite‐free nature. However, the sluggish diffusion kinetics and strong solvation capability of the strongly polarized Mg2+ are seriously limiting the specific capacity and lifespan of MIBs. In this work, catalytic desolvation is introduced into MIBs for the first time by modifying vanadium pentoxide (V2O5) with molybdenum disulfide quantum dots (MQDs), and it is demonstrated via density function theory (DFT) calculations that MQDs can effectively lower the desolvation energy barrier of Mg2+, and therefore catalyze the dissociation of Mg2+‐1,2‐Dimethoxyethane (Mg2+‐DME) bonds and release free electrolyte cations, finally contributing to a fast diffusion kinetics within the cathode. Meanwhile, the local interlayer expansion can also increase the layer spacing of V2O5 and speed up the magnesiation/demagnesiation kinetics. Benefiting from the structural configuration, MIBs exhibit superb reversible capacity (≈300 mAh g−1 at 50 mA g−1) and unparalleled cycling stability (15 000 cycles at 2 A g−1 with a capacity of ≈70 mAh g−1). This approach based on catalytic reactions to regulate the desolvation behavior of the whole interface provides a new idea and reference for the development of high‐performance MIBs.
We Belong and Connect When We Have a Voice: Towards a Learning Design for Inclusive Learning
Authors: Pinto Marta , Svoen Brit 
Published: February 2024

AbstractWhen people have their voice heard and are willing to share their stories, they become empowered with a sense of belonging and social inclusion. This chapter proposes a learning design approach for online and face-to-face learning, which aims to deliver social inclusion for adult migrants and refugees, through digital literacy. The design is based on the participation of a community encompassing students, teachers and technologists. Developing online learning resources entails being culturally and gender sensitive, through stories in every step of the learning journey, focusing on the learners needs and sense of connectedness.
Notes on gauging noninvertible symmetries. Part I. Multiplicity-free cases
Authors: Perez-Lona A. , Robbins D. , Sharpe E. , Vandermeulen T. , Yu X. 
Published: February 2024

Abstract
In this paper we discuss gauging noninvertible zero-form symmetries in two dimensions. We specialize to certain gaugeable cases, specifically, fusion categories of the form $$ \textrm{Rep}\left(\mathcal{H}\right) $$
Rep

H

for $$ \mathcal{H} $$
H
a suitable Hopf algebra (which includes the special case Rep(G) for G a finite group). We also specialize to the case that the fusion category is multiplicity-free. We discuss how to construct a modular-invariant partition function from a choice of Frobenius algebra structure on $$ {\mathcal{H}}^{\ast } $$

H
∗

. We discuss how ordinary G orbifolds for finite groups G are a special case of the construction, corresponding to the fusion category Vec(G) = Rep(ℂ[G]*). For the cases Rep(S3), Rep(D4), and Rep(Q8), we construct the crossing kernels for general intertwiner maps. We explicitly compute partition functions in the examples of Rep(S3), Rep(D4), Rep(Q8), and $$ \textrm{Rep}\left({\mathcal{H}}_8\right) $$
Rep

H
8

, and discuss applications in c = 1 CFTs. We also discuss decomposition in the special case that the entire noninvertible symmetry group acts trivially.
The θ-dependence of the SU(N) critical temperature at large N
Authors: Bonanno Claudio , D’Elia Massimo , Verzichelli Lorenzo 
Published: February 2024

Abstract
We investigate, by means of numerical lattice simulations, the θ-dependence of the critical deconfinement temperature of SU(N) gauge theories at large N : Tc(θ) = Tc(0)[1 – Rθ2 + O(θ4)], with R ~ O(1/N2). We follow two different strategies to determine R, one based on the calculation of the latent heat of the transition and on the jump of the topological susceptibility at the θ = 0 critical point, the other relying on a direct probe of Tc(θ) by means of imaginary-θ Monte Carlo simulations. Our results show that R follows the expected large-N scaling.
Development and characterization of a new sunflower source of resistance to race G of Orobanche cumana Wallr. derived from Helianthus anomalus
Authors: Fernández-Melero Belén , del Moral Lidia , Todesco Marco , Rieseberg Loren H. , Owens Gregory L. , Carrère Sébastien , Chabaud Mireille , Muños Stéphane , Velasco Leonardo , Pérez-Vich Begoña 
Published: February 2024

Abstract
Key message
A new OrAnom1 gene introgressed in cultivated sunflower from wild Helianthus anomalusconfers late post-attachment resistance toOrobanche cumana race G and maps to a target interval in Chromosome 4 where two receptor-like kinases (RLKs) have been identified in theH. anomalusgenome as putative candidates.

Abstract
Sunflower broomrape is a parasitic weed that infects sunflower (Helianthus annuus L.) roots causing severe yield losses. Breeding for resistance is the most effective and sustainable control method. In this study, we report the identification, introgression, and genetic and physiological characterization of a new sunflower source of resistance to race G of broomrape developed from the wild annual sunflower H. anomalus (accession PI 468642). Crosses between PI 468642 and the susceptible line P21 were carried out, and the genetic study was conducted in BC1F1, BC1F2, and its derived BC1F3 populations. A BC1F5 germplasm named ANOM1 was developed through selection for race G resistance and resemblance to cultivated sunflower. The resistant trait showed monogenic and dominant inheritance. The gene, named OrAnom1, was mapped to Chromosome 4 within a 1.2 cM interval and co-segregated with 7 SNP markers. This interval corresponds to a 1.32 Mb region in the sunflower reference genome, housing a cluster of receptor-like kinase and receptor-like protein (RLK-RLP) genes. Notably, the analysis of the H. anomalus genome revealed the absence of RLPs in the OrAnom1 target region but featured two RLKs as possible OrAnom1 candidates. Rhizotron and histological studies showed that OrAnom1 determines a late post-attachment resistance mechanism. Broomrape can establish a vascular connection with the host, but parasite growth is stopped before tubercle development, showing phenolic compounds accumulation and tubercle necrosis. ANOM1 will contribute to broadening the genetic basis of broomrape resistance in the cultivated sunflower pool and to a better understanding of the molecular basis of the sunflower-broomrape interaction.
Artificial intelligence applied to magnetic resonance imaging reliably detects the presence, but not the location, of meniscus tears: a systematic review and meta-analysis
Authors: Zhao Yi , Coppola Andrew , Karamchandani Urvi , Amiras Dimitri , Gupte Chinmay M. 
Published: February 2024

Abstract
Objectives
To review and compare the accuracy of convolutional neural networks (CNN) for the diagnosis of meniscal tears in the current literature and analyze the decision-making processes utilized by these CNN algorithms.

Materials and methods
PubMed, MEDLINE, EMBASE, and Cochrane databases up to December 2022 were searched in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. Risk of analysis was used for all identified articles. Predictive performance values, including sensitivity and specificity, were extracted for quantitative analysis. The meta-analysis was divided between AI prediction models identifying the presence of meniscus tears and the location of meniscus tears.

Results
Eleven articles were included in the final review, with a total of 13,467 patients and 57,551 images. Heterogeneity was statistically significantly large for the sensitivity of the tear identification analysis (I2 = 79%). A higher level of accuracy was observed in identifying the presence of a meniscal tear over locating tears in specific regions of the meniscus (AUC, 0.939 vs 0.905). Pooled sensitivity and specificity were 0.87 (95% confidence interval (CI) 0.80–0.91) and 0.89 (95% CI 0.83–0.93) for meniscus tear identification and 0.88 (95% CI 0.82–0.91) and 0.84 (95% CI 0.81–0.85) for locating the tears.

Conclusions
AI prediction models achieved favorable performance in the diagnosis, but not location, of meniscus tears. Further studies on the clinical utilities of deep learning should include standardized reporting, external validation, and full reports of the predictive performances of these models, with a view to localizing tears more accurately.

Clinical relevance statement
Meniscus tears are hard to diagnose in the knee magnetic resonance images. AI prediction models may play an important role in improving the diagnostic accuracy of clinicians and radiologists.

Key Points
•Artificial intelligence (AI) provides great potential in improving the diagnosis of meniscus tears.
•The pooled diagnostic performance for artificial intelligence (AI) in identifying meniscus tears was better (sensitivity 87%, specificity 89%) than locating the tears (sensitivity 88%, specificity 84%).
•AI is good at confirming the diagnosis of meniscus tears, but future work is required to guide the management of the disease.
On Compact Packings of Euclidean Space with Spheres of Finitely Many Sizes
Authors: Messerschmidt Miek , Kikianty Eder 
Published: February 2024

AbstractFor $$d\in {\mathbb {N}}$$

d
∈
N

, a compact sphere packing of Euclidean space $${\mathbb {R}}^{d}$$

R

d

is a set of spheres in $${\mathbb {R}}^{d}$$

R

d

with disjoint interiors so that the contact hypergraph of the packing is the vertex scheme of a homogeneous simplicial d-complex that covers all of $${\mathbb {R}}^{d}$$

R

d

. We are motivated by the question: For $$d,n\in {\mathbb {N}}$$

d
,
n
∈
N

with $$d,n\ge 2$$

d
,
n
≥
2

, how many configurations of numbers $$0<r_{0}<r_{1}<\cdots <r_{n-1}=1$$

0
<

r
0

<

r
1

<
⋯
<

r

n
-
1

=
1

can occur as the radii of spheres in a compact sphere packing of $${\mathbb {R}}^{d}$$

R

d

wherein there occur exactly n sizes of sphere? We introduce what we call ‘heteroperturbative sets’ of labeled triangulations of unit spheres and we discuss the existence of non-trivial examples of heteroperturbative sets. For a fixed heteroperturbative set, we discuss how a compact sphere packing may be associated to the heteroperturbative set or not. We proceed to show, for $$d,n\in {\mathbb {N}}$$

d
,
n
∈
N

with $$d,n\ge 2$$

d
,
n
≥
2

and for a fixed heteroperturbative set, that the collection of all configurations of n distinct positive numbers that can occur as the radii of spheres in a compact packing is finite, when taken over all compact sphere packings of $${\mathbb {R}}^{d}$$

R

d

which have exactly n sizes of sphere and which are associated to the fixed heteroperturbative set.