bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Multi‐Stimulus‐Responsive E‐Skin Based on an Ionic Film with a Counter‐Ion Exchange Reagent
Authors: Chen Baozhong , Shen Kangxin , Li Yaping , Huang Bo , Su Huiming , Xu Jintao , Yang Shuai , Zhou Qi , Lan Linfeng , Peng Junbiao , Cao Yong 
Published: February 2024

AbstractSensing pressure and temperature are two important functions of human skin that integrate different types of tactile receptors. In this paper, a deformable artificial flexible multi‐stimulus‐responsive sensor is demonstrated that can distinguish mechanical pressure from temperature by measuring the impedance and the electrical phase at the same frequency without signal interference. The electrical phase, which is used for measuring the temperature, is totally independent of the pressure by controlling the surface micro‐shapes and the ion content of the ionic film. By doping the counter‐ion exchange reagent into the ionic liquid before pouring, the upper temperature measuring limit increases from 35 to 50 °C, which is higher than the human body temperature and the ambient temperature on Earth. The sensor shows high sensitivity to pressure (up to 0.495 kPa−1) and a wide temperature sensing range (−10 to 50 °C). A multimodal ion‐electronic skin (IEM‐skin) with an 8 × 8 multi‐stimulus‐responsive sensor array is fabricated and can successfully sense the distribution of temperature and pressure at the same time. Finally, the sensors are used for monitoring the touching motions of a robot‐arm finger controlled by a remote interactive glove and successfully detect the touching states and the temperature changes of different objects.
Political and economic instrumentalisation of science: Towards an extended concept of corruption
Authors: Žažar Krešimir , Roth Steffen 
Published: February 2024

AbstractPopular perception holds that science has been distorted by the pressure of expectations of economic utility or political desirability. Grounded in Niklas Luhmann's system theory, this paper examines the interplay of the political, economic and scientific subsystem of society to scrutinise the idea that science has been corrupted by economy and politics. To this end, we extend the notion of corruption beyond the common, predominantly legal meaning. As a result, we identify organisations as loci of corruptions that can occur at the interfaces of economy, politics and law as much as at the interfaces of science, education and economy or science, politics and health. We conclude that further conceptual and empirical research on these and similar cases of corruption is a worthy scientific goal.
Learning from artificial intelligence researchers about international business implications
Authors: Ratten Vanessa , Hasan Rakibul , Kumar Deepak , Bustard John , Ojala Arto , Salamzadeh Yashar 
Published: February 2024

AbstractArtificial intelligence is a dynamic and emerging form of technological innovation that has numerous ramifications for international business managers. The aim of this article is to obtain commentary from researchers about the role artificial intelligence will play in the global arena. This includes asking questions about how it will affect internationalization processes and whether it will lead to more international collaboration. Well‐known researchers provide advice on what international business managers should do in terms of staying competitive but also how they can integrate learning from artificial intelligence into their business operations. Lastly, suggestions for future research regarding the interplay between international business and artificial intelligence are provided.
Forecasting bathing water quality in the UK: A critical review
Authors: Krupska Karolina Urszula , Speight Linda , Robinson James Stephen , Gilbert Adam James , Cloke Hannah 
Published: February 2024

AbstractClimate change is altering rainfall patterns resulting in increasing variability and intensity of rainfall events worldwide. Increases to short duration, intense rainfall (i.e., convective rainfall), will lead to increases in sewage overflow and run‐off from agricultural land. Such events generate spikes in micro‐organisms from feces and manure, especially Escherichia coli and intestinal enterococci, that temporarily end up in bathing waters posing serious health risks to bathers. Forecasting of bathing water quality associated with convective rainfall presents a distinctive forecasting challenge due to high uncertainties associated with predicting the timing, location, and impact of such events. In this article, we review examples of bathing water quality forecasting practices, with a focus on the United Kingdom where convective rainfall in the summer bathing water season is a particular concern, and question whether the current approach is robust in a changing climate. We discuss potential upgrades in bathing water forecasting and identify the main challenges that must be addressed before an improved framework for bathing water forecasting can be achieved. Although developments in meteorological and hydrological short‐range forecasting capabilities are promising, convective rainfall forecasting has significant predictability limits. We suggest taking full advantage of short‐range forecasts to provide sub‐daily bathing water forecasts, focusing on targeted bathing water monitoring regimes to improve model accuracy with the ultimate goal of providing improved information and guidance for beach users.This article is categorized under:
Science of Water > Water and Environmental Change
Human Water > Water Governance
Science of Water > Water Quality
Equilibrium, kinetic, and thermodynamic studies on the biosorption of lead by human metallothionein gene‐cloned bacteria as a novel biosorbent
Authors: Akkurt Şeyma , Uçkun Aysel Alkan , Oğuz Merve , Uçkun Miraç , Kahraman Hüseyin 
Published: February 2024

AbstractHeavy metals are the main pollutants in water and are an important global problem that threatens human health and ecosystems. In recent years, there has been an increasing interest in the use of genetically modified bacteria as an eco‐friendly method to solve heavy metal pollution problems. The goal of this study was to generate genetically modified Escherichia coli expressing human metallothioneins (hMT2A and hMT3) and to determine their tolerance, bioaccumulation, and biosorption capacity to lead (Pb2+). Recombinant MT2A and MT3 strains expressing MT were successfully generated. Minimum inhibition concentrations (MIC) of Pb for MT2A and MT3 were found to be 1750 and 2000 mg L−1, respectively. Pb2+ resistance and bioaccumulation capacity of MT3 were higher than MT2A. Therefore, only MT3 biosorbent was used in Pb2+ biosorption, and its efficiency was examined by performing experiments in a batch system. Pb2+ biosorption by MT3 was evaluated in terms of isotherms, kinetics, and thermodynamics. The results showed that Pb biosorption fits to the Langmuir isotherm model and the pseudo‐first‐order kinetic model, and the reaction is exothermic. The maximum Pb2+ capacity of the biosorbent was 50 mg Pb2+g−1. The potential of MT3 in Pb biosorption was characterized by Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), and scanning transmission electron microscopy (STEM) analyses. The desorption study showed that the sorbent had up to 74% recovery and could be effectively used four times. These findings imply that this biosorbent can be applied as a promising, precise, and effective means of removing Pb2+ from contaminated waters.Practitioner Points
In this study, the tolerance levels, bioaccumulation, and biosorption capacities of Pb in aqueous solutions were determined for the first time in recombinant MT2A and MT3 strains in which human MT2A and MT3 genes were cloned.
The biosorbent of MT3, which was determined to be more effective in Pb bioaccumulation, was synthesized and used in Pb biosorption.
The Pb biosorption mechanism of MT3 biosorbent was identified using isotherm modeling, kinetic modeling, and thermodynamic studies.
The maximum Pb removal percentage capacity of the biosorbent was 90%, whereas the maximum biosorption capacity was up to 50 mg Pb2+g−1.
These results indicated that MT3 biosorbent has a higher Pb biosorption capacity than existing recombinant biosorbents. MT3 biosorbent can be used as a promising and effective biosorbent for removing Pb from wastewater.
Interactions between microplastics and Culex sp. larvae in wastewater
Authors: Khedre Azza M. , Ramadan Somaia A. , Ashry Ali , Alaraby Mohamed 
Published: February 2024

AbstractMicroplastics (MPs) are a growing issue because they endanger both aquatic organisms and humans. Studies have indicated that wastewater treatment plants (WWTPs) are one of the major contributors to MPs in the environment. However, studies on the abundance of MP contamination in WWTPs and its transmission into aquatic organisms are still scarce, especially in Egypt. The goal of this study was to examine the temporal fluctuations in the distribution of MPs in surface water and the dominant macroinvertebrate fauna (Culex sp. larvae) in a fixed wastewater basin in Sohag Governorate, Egypt. The average of MPs in the surface water was 3.01 ± 0.9 particles/L. The results indicated to seasonal variation of MP abundance in the wastewater basin that was significantly higher in winter than in the other seasons. The risk index for polymers (H), pollution load index (PLI), and potential ecological risk index (RI) were used to assess the degree of MP contamination. The basin has moderate H values (<1000) because of the presence of polymers with moderate hazard scores such as polyester (PES), polyethylene (PE), and polypropylene (PP). According to the PLI values, surface water is extremely contaminated with MPs (PLI: 88 to 120). The RI values of surface water showed higher ecological risk (level V). MPs in Culex sp. larvae were seasonally changed with an 85% detection rate, and an abundance average of 0.24 ± 0.65 particles/ind, MP concentration in Culex sp. larvae was influenced by the MP characters (shape, color, and polymer). The larvae of Culex sp. showed a greater preference for black and red fibrous polyester (PES) with sizes (<1000 μm) of MPs. These findings suggest that Culex sp. larvae prefer ingesting MPs that resemble their food. It is possible to overestimate Culex sp.'s preference for lower sizes because of their catabolism of MPs. To better understand the preferences of Culex sp. larvae for MPs, further controlled trials should be conducted.Practitioner Points
Wastewater is highly contaminated with microplastics (MPs) in the different seasons.
First report of detection of the seasonal abundance of MP in Culex sp. larvae.
Culex sp. larvae showed a stronger feeding preference for MPs with specific characteristics.
Smaller size and blue polyester fibers were the dominant characteristics of MPs in wastewater.
The Data Mine model for accessible partnerships in data science
Authors: Betz Margaret A. , Sharples Rebecca L. , Ward Mark Daniel 
Published: February 2024

AbstractThe Data Mine at Purdue University is a pioneering experiential learning community for undergraduate and graduate students of any background to learn data science. The first data‐intensive experience embedded in a large learning community, The Data Mine had nearly 1300 students in academic year (AY) 2022–2023 and nearly 1700 students for AY 2023–2024. The Data Mine embodies data‐infused education, research, and collaboration. Students learn Python, R, SQL, and shell‐scripting, while working on weekly projects within a high‐performance computing (HPC) cluster. In the Corporate Partners cohort, students work on teams of 5–15 students, led by a paid student team leader. Each cohort follows an Agile approach, working on data‐intensive projects provided by industry partners and mentored by company employees. Students develop professional and data skills throughout the academic year, from August through April. Many students return in subsequent years to the program, increasing their tenure with a Corporate Partner. Student teams are inherently interdisciplinary; students from 133 different majors are involved in the program, ranging from new incoming students through PhD level students. These interdisciplinary teams of students bring new perspectives to challenging problems in which data science is a key part of the solution. The interdisciplinary teams foster an environment of synthesis with ideas and solutions. Students come together with different life experiences, different levels of technical skill, but also varying ways they navigate paths to solutions because of the variety of majors represented, resulting in a more creative and robust solution than a traditional data science program.This article is categorized under:
Applications of Computational Statistics > Education in Computational Statistics
Management of intraoperatively identified small bile duct stones in patients undergoing cholecystectomy
Authors: Bunting David , Adesuyi Abidemi , Findlay John , Pawlak Maciej , Sanders David 
Published: February 2024

Abstract
Introduction
The management of CBDS (common bile duct stones) in patients with co-existing gallbladder stones has been debated. Guidelines recommend patients with CBDS identified on imaging should be offered duct clearance; however, this is based on low-quality evidence. This study aimed to investigate the natural history of small CBDS identified using IOUS (intraoperative ultrasound) in patients undergoing cholecystectomy. This may provide evidence to support a short-term expectant management approach in such patients.

Methods
Patients with CBDS diagnosed on IOUS during cholecystectomy were identified from a database of consecutive patients undergoing surgery. Patients with CBDS identified were divided into small stone (SS, ≤5 mm) and large stone (LS, >5 mm) groups. Intraoperative CBDS management, postoperative investigations, postoperative bile duct clearance, re-admissions, complications, length of stay (LOS) and follow-up are described.

Results
Fifty-nine of 427 patients had CBDS identified on IOUS. In the SS group (n=51), 46 patients underwent short-term expectant management rather than immediate/planned bile duct clearance. Following short-term expectant management, 41/46 patients (89.1%) did not require postoperative endoscopic retrograde cholangiopancreatography and at >3 year follow-up, none has since presented with residual CBDS. Median LOS was 0 days in the short-term expectant management group and 2 days in the immediate/planned bile duct clearance group, P=0.039.

Conclusions
This study reports the natural history of small CBDS identified on IOUS in patients undergoing cholecystectomy. Such patients were safely treated with short-term expectant management associated with a reduced hospital LOS. This provides rationale for undertaking further research to establish this as a preferred management strategy.
First-line treatment of driver gene-negative metastatic lung adenocarcinoma with malignant pleural effusion: Should chemotherapy be combined with an immune checkpoint inhibitor or bevacizumab?
Authors: Zhao Yuanyuan , Mei Ting , Na Feifei , Tian Xiaoman , Ao Rui , Long Xiangyu , Luo Qiang , Duan Ping , Zhu Jiang , Wang Yongsheng , Huang Meijuan , Liu Yongmei , Gong Youling 
Published: February 2024

SummaryPatients with metastatic lung adenocarcinoma (MLA) and malignant pleural effusion (MPE) without driver gene mutations have a poor prognosis. None of the standard treatment strategies is recommended for such patients. We retrospectively analyzed the efficacy of the first-line treatment for this specific population: standard platinum-based doublet chemotherapy (CT), CT plus an immune checkpoint inhibitor (CT plus ICI), and CT plus bevacizumab (CT plus Bev). A total of 323 eligible patients were enrolled: CT alone (n = 166), CT plus Bev (n = 72), and CT plus ICI (n = 85). Treatment efficacy assessments were performed every two cycles according to the RECIST guidelines. The endpoints were overall survival (OS) and progression-free survival (PFS). Kaplan-Meier (K‒M) curves and the log-rank test were used to compare OS and PFS. p < 0.05 was the threshold of significance (statistical software: SPSS). The median follow-up was 11.4 months (range, 2.1–49.6 months). PFS and OS in the CT plus ICI/CT plus Bev cohort were significantly longer than those in the CT group (PFS: 7.8/6.4/3.9 months, p < 0.0001; OS: 16.4/15.6/9.6 months, p < 0.0001, respectively). CT plus Bev had better PFS and OS than CT plus ICI/CT in PD-L1 < 1% patients (PFS: 8.4/5.0/3.8 months, p < 0.0001; OS: 15.6/12.9/9.3 months, p < 0.0001). Among patients with PD-L1 1–49%, CT plus ICI led to a longer PFS and OS (PFS: 8.9/5.8/4.2 months, p = 0.009; OS: 24.2/18.8/11.5 months, p = 0.03). In the cohort with PD-L1 ≥ 50%, CT plus ICI was still the best first-line treatment (PFS: 19.7/13.8/9.6 months, p = 0.033; OS: 27.2/19.6/14.9 months, p = 0.047). In driver gene-negative MLA with MPE, CT plus Bev or ICI better controlled MPE and significantly prolonged survival compared to CT alone. PD-L1 expression (negative/positive) may be a key factor influencing the choice of CT plus Bev or ICI.
Palliative radiotherapy for painful non-bone lesions in patients with advanced cancer: a single center retrospective study
Authors: Shindo Yurika , Koide Yutaro , Nagai Naoya , Kitagawa Tomoki , Aoyama Takahiro , Shimizu Hidetoshi , Hashimoto Shingo , Tachibana Hiroyuki , Kodaira Takeshi , Ishihara Shunichi , Naganawa Shinji 
Published: February 2024

Abstract
Purpose
This retrospective study aimed to assess the efficacy and safety of palliative radiotherapy for painful non-bone lesions in patients with advanced cancer.

Materials and methods
We enrolled patients with painful non-bone lesions who underwent conventional palliative radiotherapy between September 2018 and September 2022. The treatment targets included primary tumor lesions, lymph node metastases, non-bone hematogenous metastases, and other lesions. The primary endpoint was the overall pain response rate in evaluable patients, determined based on the International Consensus Pain Response Endpoint criteria. The secondary endpoints included overall survival, pain recurrence, and adverse events.

Results
Of the 420 screened patients, 142 received palliative radiotherapy for painful non-bone lesions, and 112 were evaluable. A pain response was achieved in 67 patients (60%) of the 112 evaluable patients within a median of 1.2 months. Among these patients, 25 exhibited complete response, 42 partial response, 18 indeterminate response, and 27 pain progression. The median survival time was 5.5 months, recorded at a median follow-up of 6.0 months, during which 67 patients died. Multivariate analysis identified poor performance status scores of 2–4, opioid use, and re-irradiation as independent factors associated with a reduced likelihood of achieving a pain response. Pain recurrence occurred in 18 patients over a median of 4.1 months. Seventeen patients had grade 1–2 adverse events, while none experienced grade 3 or higher toxicity.

Conclusion
Palliative radiotherapy can potentially be a safe and well-tolerated modality for managing painful non-bone lesions, with a low rate of adverse events.
Conceptualising State-Centric Mediation: An Analysis of China's Foreign Investment Complaints Mechanism
Authors: McLaughlin Mark 
Published: February 2024

AbstractThis article argues that China's foreign investor complaints system constitutes ‘state-centric investment mediation’. The Rules on Handling Complaints of Foreign-Invested Enterprises, which entered into force on 1 October 2020, place a state agency in the position of facilitating negotiations between a foreign investor and the agency being complained against. The prospects for this complaints system depend on how the state-as-mediator dynamic is perceived by foreign investors. To this end, it will be argued that settlement agreements reached pursuant to this system may be enforceable under the Singapore Convention on Mediation in certain circumstances. Investors and government entities operating similar systems worldwide should be cognisant of the broad drafting terminology of the Singapore Convention. Moreover, it is proposed that further clarification of the procedural rules and the inclusion of China's foreign-related dispute resolution institutions may enhance investor confidence and encourage use of the complaints system.
Waste not, want not: Value chain stakeholder attitudes to surplus dairy calf management in Australia
Authors: Bolton Sarah E , Vandresen Bianca , von Keyserlingk Marina AG 
Published: February 2024

Abstract
The management of surplus dairy calves in Australia has traditionally been influenced by the economic viability of different practices. When beef prices are favourable, more surplus calves are raised for beef, and when beef prices are low, more calves are killed in the first few days of life. Early life killing of surplus calves may however threaten the dairy industry’s social licence to operate. The aim of this study was to describe the views of value chain stakeholders regarding the management of surplus calves. Representatives from seven post-farm gate organisations participated in semi-structured interviews and were asked about their views on current practices, alternatives to early life killing and how best to implement change. Responses were analysed using inductive thematic analysis and were organised into three themes: (1) ethics of surplus calf management; (2) economics of surplus calf management; and (3) moving towards solutions including approaches to affecting change. We conclude that stakeholders widely recognised early life killing of surplus calves as a threat to the industry’s social licence. Whilst technical solutions such as beef on dairy breeding programmes were cited as important, participants emphasised that implementing sustainable solutions will require collaboration, leadership, and commitment by all stakeholders along the value chain.
To Blockade or Not To Blockade? The Legal Status of Russia's Suspension of Shipping in the Sea of Azov
Authors: Friedman Shani 
Published: February 2024

AbstractThis article explores the legal situation relating to the Sea of Azov in the light of the Russian suspension of shipping on 24 February 2022. While this act received little scholarly or political attention, there is a debate concerning the legality of the suspension of shipping, mainly whether it is governed by the law of naval blockade under the laws of naval warfare. The article analyses the situation from the perspectives of both international humanitarian law (IHL) and the law of the sea (LOS) and examines how the interaction between the two legal regimes affects the analysis. The article supports the conclusion that the Russian conduct does not constitute a naval blockade but may be an accepted practice within the legal regime of naval warfare. In addition, it holds that LOS affects both the laws of naval warfare and the status of the Sea of Azov. Furthermore, the article raises doubts as to the relevance and applicability of the legal concept of naval blockade in modern international law.