bluuebunny/crossref_metadata_2025_split huggingface dataset:
Celiac Disease in Medical Curriculum
Authors: Kerns Elizabeth , Husmann, PhD Polly R. 
Published: January 2024

Introduction: Celiac disease is a common autoimmune illness precipitated by the ingestion of gluten, a protein contained in grains (e.g., wheat, barley, and rye). Celiac disease can present with a wide variety of manifestations across nearly any body system, but most individuals with celiac disease present with subclinical symptoms. Despite relatively inexpensive testing and an effective treatment (i.e., a gluten free diet), most individuals with celiac disease remain undiagnosed, leading to significant disease burden. Research suggests that physicians have poor knowledge of celiac disease, likely contributing to the high rates of missed diagnoses. This study sought to assess the information encountered by students in pre-clinical medical education regarding celiac disease.
Methods: Information was drawn from recent literature to create a rubric to evaluate the presentation of celiac disease in curricular and educational resources for pre-clinical medical students. Categories evaluated included prevalence, morbidity/mortality, manifestations, comorbidities, and testing recommendations. This rubric was used to assess the curriculum from a large US medical school and First Aid for the USMLE Step 1, a popular commercial resource used by medical students.
Results: The medical school curriculum scored higher overall than First Aid (31/48 and 12/48, respectively). The curriculum also scored higher in all categories except morbidity/mortality. The curriculum showed deficits predominantly in morbidity/mortality and testing recommendations. First Aid showed deficits in all categories.
Discussion: Results showed that the medical school curriculum provided more complete information about several aspects of celiac disease. First Aid did not thoroughly address any of the categories evaluated with the rubric. While First Aid may be an effective consolidation of Step 1 material, it seems likely that it is focused on “teaching to the test” rather than providing thorough medical education for future physicians. The medical curriculum is a more complete resource for students to learn about celiac disease.
ENSAIO FOTOGRÁFICO | MIGUEL CHIKAOKA
Authors: Chikaoka Miguel 
Published: January 2024

Apresentamos aqui o Ensaio Fotográfico especial de Miguel Chikaoka a partir do projeto O fazer teatral em Belém do Pará 1980/90: Lugar de aprendizados¹ realizado em 2021, contemplado com o Edital Multilinguagens - Lei Aldir Blanc Pará. Apresentado na exposição homônima com curadoria de Claudio Barros, Valéria Andrade e Wlad Lima.Para nós este trabalho é de suma importância por ser um recorte da história do teatro paraense das décadas de 1980 e 90, a partir de espetáculos que fazem parte da memória das artes cênicas amazônicas, registrados pelo olhar desse importante artista.Para a historiografia, fotografias são importantes fontes visuais para o exercício crítico sobre as práticas culturais. No caso do ensaio de Miguel Chikaoka, temos acesso a elementos poéticos que registram, pelo olhar sensível e criativo do artista, as performances na cena de artistas e obras que compõe o imaginário cultural paraense. Daí, reativamos o ensaio, agregamos fotografia e reeditamos, acreditando na potência dessas experiências vivas do teatro paraense.Assim, as imagens do artista juntam-se aos vários modos de contar histórias e como este número da Revista Arteriais é dedicado aos processos historiográficos teatrais, apresentamos cenas das memórias cênicas paraenses fundamentais para compreendermos o passado e imaginarmos o porvir, traduzidas pelo olhar sensível e atento de Miguel Chikaoka.Os Editores. ¹ As fotografias que compõem este ensaio fotográfico foram cedidas, gentilmente, pelo artista à Revista Arteriais e estão disponíveis no site da galeria Kamara Kó: <https://www.kamarakogaleria.com.br/galeria-t80-90>. Ficha técnica: Fotografias e coordenação geral de Miguel Chikaoka. Curadoria - artistas convidados: Claudio Barros, Valéria Andrade, Wlad Lima. Produção executiva: Makiko Akao. Assessoria de comunicação: Yvana Crizanto. PROJETO GRÁFICO E SOCIAL MEDIA: Brena Souza. DIGITALIZAÇÃO DE IMAGENS: Samir Damasceno. WEBDESIGN: Flavya Mutran. Realização: Kamara Kó Galeria.
PHYTOPHYSIOGNOMIES OF THE REDUCED FLOW STRETCH OF THE BELO MONTE HYDROELECTRIC POWER PLANT IN PARÁ, BRAZIL
Authors: Santos Ana Júlia Moreira dos , Ribeiro Cleber Da Silva , Silva Nadson De Pablo Costa , Reis Alisson Rodrigo Souza 
Published: January 2024

The Belo Monte hydroelectric power plant has a section known as the reduced flow stretch (RFS). In this area, the environmental classification of vegetation was based on unclear criteria and various inconsistencies. In view of this, the objective of the present study is to delimit and classify the phytophysiognomy and flora of this area by analyzing the botanical material collected at the RFS in 2019 in Belo Monte Hydroelectric Power Plant, Xingu River, Brazil. This material was described and systematized according to the APG IV classification system and compared with the existing literature on the theme for the definition of phytophysiognomies. Thus, the study identified 514 individuals distributed in 74 families, 180 genera, and 185 species, while the previously used names Sarobal, Beiradão, Açaizal, Grota, Restinga, Ilha, and Golosal do not correspond to distinct or scientifically recognized phytophysiognomies. Technical reports must be adapted to the scientifically recognized phytophysiognomies
Human Rights and Its Contested Legal Paradigm
Authors: Putro Widodo Dwi 
Published: January 2024

This article examines the philosophical foundation of the tension between two contested legal paradigms, namely the Sociological Jurisprudence and Historical School of Jurisprudence, and how the contestation affects human rights discourse in Indonesia. Sociological jurisprudence perceives law as a tool of social engineering, while the Historical School of Jurisprudence argues that the development of law is a subconscious and organic process. Such contested legal paradigms are relevant to the case of “kawin tangkap” or bride kidnapping in Sumba, East Nusa Tenggara Indonesia. This is certainly problematic from the human rights perspective, as it is contradictory to the protection of women and children. However, like in some other traditions, the practice has been continuously preserved in local communities. The article employs legal anthropology research methods to delve into the symbols and meanings embedded within the customary laws obeyed by local communities. Additionally, this research utilizes legal philosophy methodologies to scrutinize paradigmatic disputes among schools of thought and how these disputes affect the rights of women. The study also investigates variances in perspectives concerning customary law, state law, and human rights, particularly in the context of examining the tradition of captive bride kidnapping. The challenge lies in how human rights can be employed to foster a gradual shift away from deeply ingrained patriarchal cultural norms and practices, with the aim of enhancing the protection of women’s and children’s rights, all while preserving customary laws and the harmony of local communities. This article endeavors to address this challenge by advocating for effective communication strategies that encourage local communities to embrace human rights principles and abide by the law, driven by rational awareness. The findings from this research conscientiously raise awareness about human rights within local communities through effective legal communication, without disrupting the existing local order.

Keywords: Human Rights, Historical School of Jurisprudence, Bride Kidnapping, Sociological Jurisprudence, Communication.
Regulations and Funding to Create Enterprise Architecture for a Nationwide Health Data Ecosystem
Authors: Seidman Gabriel , AlKasir Ahmad , Ricker Kate , Lane J. T. , Zink Anne B. , Williams Michelle A. 
Published: January 2024

The COVID-19 pandemic highlighted the United States’ lack of a nationwide infrastructure for collecting, sharing, and using health data, especially for secondary uses (e.g., population health management and public health). The federal government is taking several important steps to upgrade the nation’s health data ecosystem—notably, the Centers for Disease Control and Prevention’s Data Modernization Initiative and the Office of the National Coordinator for Health Information Technology’s Trusted Exchange Framework and Common Agreement. However, substantial barriers remain. Inconsistent regulations, infrastructure, and governance across federal and state levels and between states significantly impede the exchange and analysis of health data. Siloed systems and insufficient funding block effective integration of clinical, public health, and social determinants data within and between states. In this analytic essay, we propose strategies to develop a nationwide health data ecosystem. We focus on providing federal guidance and incentives to develop state-designated entities responsible for the collection, integration, and analysis of clinical, public health, social determinants of health, claims, administrative, and other relevant data. These recommendations include a regulatory clearinghouse, federal guidance, model legislation and templated regulation, funding to incentive enterprise architecture, regulatory sandboxes, and a 3-pronged research agenda. ( Am J Public Health. 2024;114(2):209–217. https://doi.org/10.2105/AJPH.2023.307477 )
The association between common mental disorders, socioeconomic outcomes and social mobility: A systematic review
Authors: Oshinowo Iyinoluwa Deborah , Barnett Phoebe , Cooper Christopher , Smith Shubulade , Taylor Clare , Pilling Stephen 
Published: January 2024

Abstract
Purpose: The aim of this systematic review was to identify published evidence on the association between common mental disorders (CMDs), changes in socioeconomic outcomes, and social mobility.
Methods: Systematic literature searches were conducted across seven databases up to May 2022. Quantitative studies were included based on the following criteria: 1) cohort study design, 2) the population had a common mental disorder, 3) Outcomes reported related to social mobility and social class (due to the limited direct measures of social mobility and social class, changes in socioeconomic outcomes were included as proxies of social mobility). The identified studies were analysed using narrative synthesis.
Results: There was more evidence for the negative intragenerational than intergenerational association of CMDs on educational attainment, income, and occupational status. Considering the intergenerational association on educational attainment, there was an association between parental mental health disorders on parent-child interactions which subsequently affects their child’s mental health. This in turn may negatively impact their child’s educational progression. Only one study investigated the direct association of CMDs with changes in social class and subsequent social mobility.
Conclusion: Given the evidence of the negative intragenerational association between CMDs and socioeconomic outcomes, it is important to promote mental health interventions adapted to the work and educational environment that adequately equip individuals to maintain their own mental health. Additionally, within the home environment, there is a need to further understand how negative parent-child interactions impact a child’s mental health and develop strategies to mitigate how this may impact subsequent social mobility.
Habituation to threats in times of crisis: Lessons from the temporal trajectory of risk perceptions throughout COVID-19
Authors: Grillo Tito L.H. , Henderson Ty , Ward Adrian F. 
Published: January 2024

Abstract
From wars to epidemics to economic recessions, societies worldwide are subject to extended periods of crisis. Perceptions of crisis-related risks are crucial for how people respond to communications about ongoing threats, protective behaviors, and crisis-management policies. However, people’s perceptions often do not accurately reflect the reality around them. The authors test a habituation-to-threat pattern that can produce a mismatch between risk perceptions and actual threats over the course of sustained crises: initially, people feel highly at risk despite low levels of objective threat; as crises persist, perceived risks decline even in the face of increasing objective threat levels. Consistent with this pattern, participants in a nationwide American survey conducted bi-weekly for more than a year during the COVID-19 pandemic initially estimated high probabilities that they could contract the virus, be hospitalized, and even die. However, as the number of people affected by COVID-19 increased, these risk perceptions declined instead.
Growth phase-dependent reorganization of cryptophyte photosystem I antennas
Authors: Li Mei , Zhang Shumeng , Si Long , Su Xiaodong 
Published: January 2024

Abstract

Cryptophytes are oxyphototrophic algae that utilize membrane-embedded chlorophyll a/c binding proteins (CACs) and lumen-localized phycobiliproteins (PBPs) as their light-harvesting antennas. Here we solved four structures of cryptophyte photosystem I (PSI) bound with CACs that show the rearrangement of CACs in different growth phases. We identified a cryptophyte-unique protein, PsaQ, which specifically binds to the lumenal region of PSI during logarithmic growth phase, suggesting a potential role in binding PBPs.
Duration of Endocrine Treatment for DCIS impacts second events: Insights from a large cohort of cases at two academic medical centers
Authors: O'Keefe Thomas , Yau Christina , Iaconetti Emma , Jeong Eliza , Brabham Case , Kim Paul , McGuire Joseph , Griffin Ann , Wallace Anne M. , Esserman Laura J. , Harismendy Olivier , Hirst Gillian L. 
Published: January 2024

Abstract
Ductal carcinoma in situ (DCIS) incidence has risen rapidly with the introduction of screening mammography, yet it is unclear who benefits from both the amount and type of adjuvant treatment (radiation therapy, (RT), endocrine therapy (ET)) versus what constitutes over-treatment. Our goal was to identify the effects of adjuvant RT, or ET+/- RT versus breast conservation surgery (BCS) alone in a large multi-center registry of retrospective DCIS cases (N = 1,916) with median follow up of 8.2 years. We show that patients with DCIS who took less than 2 years of adjuvant ET alone have a similar second event rate as BCS. However, patients who took more than 2 years of ET show a significantly reduced second event rate, similar to those who received either RT or combined ET+RT, which was independent of age, tumor size, grade, or period of diagnosis. This highlights the importance of ET duration for risk reduction.

*Thomas O’Keefe and Christina Yau are joint co-authors.
Pan-cancer copy number variant analysis identifies optimized size thresholds and co-occurrence models for individualized risk-stratification
Authors: Raleigh David , Nguyen Minh , Chen William , Zakimi Naomi , Mirchia Kanish , Lucas Calixto-Hope 
Published: January 2024

Abstract
Chromosome instability leading to accumulation of copy number gains or losses is a hallmark of cancer. Copy number variant (CNV) signatures are increasingly used for clinical risk-stratification, but size thresholds for defining CNVs are variable and the biological or clinical implications of CNV size heterogeneity or co-occurrence patterns are incompletely understood. Here we analyze CNV and clinical data from 565 meningiomas and 9,885 tumors from The Cancer Genome Atlas (TCGA) to develop tumor- and chromosome-specific CNV size-dependent and co-occurrence models for clinical outcomes. Our results reveal prognostic CNVs with optimized size thresholds and co-occurrence patterns that refine risk-stratification across a diversity of human cancers.
Isolation and identification of a high-efficiency hexavalent uranium adsorption strain and preliminary study of the influencing factors and adsorption mechanism
Authors: Wu Faming , Li Xiang , Wei Peng , Liu Zhirong 
Published: January 2024

Abstract
In this study, a bacterial strain WK-3 with high adsorption efficiency of hexavalent uranium U(VI) was isolated from the rhizosphere soil of a uranium (U) tailings in southern China, with an adsorption rate of 92.3%, and was identified as Chryseobacterium bernardetii. The influence of different environmental conditions on the adsorption rate of Chryseobacterium bernardetii was investigated, and the adsorption mechanism was preliminarily discussed by scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS). The results showed that: 1) The optimal adsorption conditions for Chryseobacterium bernardetii were pH = 5, temperature 30 ℃, NaCl concentration 1%, and inoculation volume 10%; 2) Under the condition of initial concentration of 50 mg/L U(VI), the maximum adsorption rate of Chryseobacterium Bernardetii was reached and maintained in equilibrium within 24 h; Under the condition of initial concentration of 50 ~ 150 mg/L U(VI), the time for Chryseobacterium bernardii to reached its maximum adsorption rate and maintained equilibrium was extended to 48 h; 3) Under the condition of initial concentration of ≥ 200 mg/L U(VI), Chryseobacterium bernardii did not grow and had no adsorption capacity; 4) Under the condition of coexistence of 2 mmol/l Zn(II) and 50 mg/L U(VI), the adsorption of Chryseobacterium bernardii to U(VI) was significantly inhibited. ESM-EDS results show that phosphorus in cells participates in the interaction of uranyl ions, which may indicate that phosphate is produced during cell metabolism and is further combined to form U(VI)-phosphate minerals. Meanwhile, the possibility of complexation between cell surface groups and U(VI) cannot be ruled out.
Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers
Authors: Nelander Sven , Larsson Ida , Held Felix , Popova Gergana , Koc Alper , Kundu Soumi , Jörnsten Rebecka 
Published: January 2024

Abstract

Nervous system cancers contain a large spectrum of transcriptional cell states, reflecting processes active during normal development, injury response and growth. However, we lack a good understanding of these states' regulation and pharmacological importance. Here, we describe the integrated reconstruction of such cellular regulatory programs and their therapeutic targets from extensive collections of single-cell RNA sequencing data (scRNA-seq) from both tumors and developing tissues. Our method, termed single-cell Regulatory-driven Clustering (scRegClust), splits target genes into modules and predicts essential kinases and transcription factors in little computational time thanks to a new efficient optimization strategy. Using this method, we analyze scRNA-seq data from both adult and childhood brain cancers to identify transcription factors and kinases that regulate distinct tumor cell states. In adult glioblastoma, our model predicts that blocking the activity of PDGFRA, DDR1, ERBB3 or SOX6, or increasing YBX1-activity, would potentiate temozolomide treatment. We further perform an integrative study of scRNA-seq data from both cancer and the developing brain to uncover the regulation of emerging meta-modules. We find a meta-module regulated by the transcription factors SPI1 and IRF8 and link it to an immune-mediated mesenchymal-like state. Our algorithm is available as an easy-to-use R package and companion visualization tool that help uncover the regulatory programs underlying cell plasticity in cancer and other diseases.
Testing an informatics consulting service for systematic bias using negative control reference sets
Authors: Jackson Michael , Gombar Saurabh , Manickam Raj , Brown Robert , Tekumalla Ramya , Ballentine Phillip , Low Yen 
Published: January 2024

Abstract

Background
We used negative control reference sets to estimate whether automated statistical methods can lead to unbiased effect estimates in the context of a clinical informatics consult.
Methods
We used clinical data from two national databases and one regional academic medical center. We used treatment-comparator-outcome triads defined by the Observational Health Data Sciences and Informatics network as negative control reference sets. For each set, we estimated the hazard ratio for the outcome between populations exposed to treatment vs. comparator medication in each dataset via a new-user cohort design. We estimated hazard ratios both unadjusted and adjusted via demographic and propensity score matching.
Results
Unadjusted estimates showed systematic bias in all three databases, with expected absolute systematic error (EASE) up to 0.19. In contrast, bias was minimal after propensity score adjustment (EASE range, -0.04 to 0.04) and propensity score matching yielded low mean squared error. After empirical calibration, the false positive rates were as expected (type one error rate of close to 0.05).
Conclusions
Data-driven propensity score matching has been shown to produce estimates consistent with manual confounder adjustment, but it is not known whether such methods are consistent with true population values. Through the use of negative controls, where the true association is known to be null, we have shown that automated confounder adjustment can produce estimates that are free of systematic bias in the context of clinical informatics consulting.
Hydrophobic and anti-fouling polyelectrolyte complex coating for durable flame-retardant cotton fabric
Authors: He Jia-Lin , Luo Wei , Deng Jin-Ni , Wang Ting , Fu Zhi-Cheng , Xia Chang-Lin , Huang Sheng-Chao , Chen Ming-Jun 
Published: January 2024

Abstract

Surface treatment is one of the most effective ways to impart flame retardancy to fabrics, woods, etc. Especially, water-soluble polyelectrolyte complex (PEC) coating deposition is one of the most environmentally benign and facile technologies. However, durability, especially washing durability, remains a huge challenge for almost all PEC coated materials. In an effort to keep the desirable flame retardancy of cotton against multiple washing, in this work, perfluorodecyltrichlorosilane modified polyethylenimine (PEI) was prepared to coat onto the ammonium polyphosphate (APP) based PEC coating. The extra 2 wt% fluorinated PEI have not only hardly lost the high LOI value (28.5%) of 10 wt% PEC-coated cotton, but also endowed this coated cotton with high water contact angle of 117 °. And the treated cotton displayed excellent antifouling performance to milk, coffee, honey, cola and ink. Notably, it still preserved self-extinguishing behavior on a vertical flame test, and high LOI value of 26.5%, after vigorously stirring in water at 40°C for 20 times. This facile and efficient method could provide a new strategy for durable flame-retardant cotton fabric against humid and pollutant conditions.
Evolution of resistance to KRASG12C inhibitor in a non-small cell lung cancer responder
Authors: Leung Elaine , Xu Jiahui , Wang Shijia , Wang Ziming , Huang Jumin , Xie Chun , Cao Yabing , Ming Chen 
Published: January 2024

Abstract
Despite initial therapeutic successes, most patients with non-small cell lung cancer (NSCLC) who carry the KRASG12C mutation ultimately exhibit resistance to targeted treatments. To improve our comprehension of how acquired resistance develops, we present an unprecedented longitudinal case study profiling the transcriptome of peripheral blood mononuclear cells (PBMCs) over 5 months from an NSCLC patient with the KRASG12C mutation and initial response to sotorasib followed by resistance and death. Single-cell RNA sequencing analysis uncovered notable fluctuations in immune cell populations throughout treatment with sotorasib. Specifically, we observed a decline in circulating CD8+CD161hi T cells correlating with periods of therapeutic response, followed by a resurgence during phases of nonresponse. This study established a high-resolution atlas detailing the evolutionary trajectory of resistance to sotorasib and characterizes a CD8+CD161hi T cells population in KRASG12C mutation patient.