bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in research of exosomes associated with breast cancer over the past decade: a scientometric analysis
Authors: Wu Jiaxin , Zheng Daitian , Wang Haiting , Zhou Zhongming , Yang Qiuping , Wu Jinyao , Tian Huiting , Ji Zeqi , Chen Lingzhi , Cai Jiehui , Chen Yexi , Li Zhiyang 
Published: October 2023

IntroductionBreast cancer remains a significant global health challenge, accounting for 2.3 million new cases in 2020 and ranking as the most prevalent cancer by incidence and the fourth in cancer-related mortality worldwide. In China, breast cancer also rapidly increases incidence and burden. The research of exosomes in breast cancer has attracted more and more attention and has a rapid development. Recognizing the pivotal role of exosomes in breast cancer research, we have undertaken a comprehensive scientometric analysis of pertinent scholarly articles published over the past decade to elucidate the current research landscape for researchers.MethodsIn this study, we gathered all pertinent publications from the Web of Science. Biblioshiny (a web interface for Bibliometrix), VOSviewer software, and CiteSpace software were used to analyze the information on publications, including global trends, countries, institutions, journals, authors, keywords, and citations.ResultsA total of 1,239 articles and 625 review articles were retrieved. The annual global publication output has an increased trend in recent decades overall. China contributed the most articles. The publications of the USA had the most total link strength. Nanjing Medical University had the most total link strength. The most relevant source was the International Journal of Molecular Sciences. Tang JH contributed the most articles and had the highest H-index, G-index, and total link strength. The most cited document was “Tumor exosome integrins determine organotropic metastasis”, with 2730 citations. The basic themes included “exosomes”, “expression”, “cells”, “identification”, “biomarkers”, and “serum”. The keyword “membrane vesicle” had the strongest bursts. The keywords “target”, “biology”, “suppressor cell”, “molecular mechanism”, “tumor progression”, “inhibitor”, and “model” appeared as prominent focal points in current research and active areas of exploration.ConclusionOver the past decade, exosome research in breast cancer has undergone a discernible evolution, shifting from broader investigations of exosome roles to focused exploration of specific pathways relevant to breast cancer. Notably, the emphasis has extended to the clinical application of exosomes as biomarkers and potential therapeutic agents in breast cancer treatment.
An opponent model for agent-based shared decision-making via a genetic algorithm
Authors: Lin Kai-Biao , Wei Ying , Liu Yong , Hong Fei-Ping , Yang Yi-Min , Lu Ping 
Published: October 2023

IntroductionShared decision-making (SDM) has received a great deal of attention as an effective way to achieve patient-centered medical care. SDM aims to bring doctors and patients together to develop treatment plans through negotiation. However, time pressure and subjective factors such as medical illiteracy and inadequate communication skills prevent doctors and patients from accurately expressing and obtaining their opponent's preferences. This problem leads to SDM being in an incomplete information environment, which significantly reduces the efficiency of the negotiation and even leads to failure.MethodsIn this study, we integrated a negotiation strategy that predicts opponent preference using a genetic algorithm with an SDM auto-negotiation model constructed based on fuzzy constraints, thereby enhancing the effectiveness of SDM by addressing the problems posed by incomplete information environments and rapidly generating treatment plans with high mutual satisfaction.ResultsA variety of negotiation scenarios are simulated in experiments and the proposed model is compared with other excellent negotiation models. The results indicated that the proposed model better adapts to multivariate scenarios and maintains higher mutual satisfaction.DiscussionThe agent negotiation framework supports SDM participants in accessing treatment plans that fit individual preferences, thereby increasing treatment satisfaction. Adding GA opponent preference prediction to the SDM negotiation framework can effectively improve negotiation performance in incomplete information environments.
Burning bright or burning out: a qualitative investigation of leader vitality
Authors: Shapiro Jamie 
Published: October 2023

IntroductionLeaders of organizations have incessant demands placed on them, including cultivating teams, building culture, and increasing the bottom line, in addition to caring for followers’ well-being and thriving. Numerous resources are required to meet these continuous demands, and vitality is one of the most valuable.MethodsThrough interviewing 20 of the most influential and pressured leaders ofFortune 1,000companies, this qualitative study answers three important questions: what drains vitality, what fosters it, and how do leaders most effectively utilize vitality for followers?ResultsThe results shed light on psychological mechanisms that drain leaders’ vitality, including emotional labor, self-control, loss of job control, the unproductive mindsets of others, and isolation created from the role. In terms of fostering vitality, several of the pathways of the PERMA+4 model of well-being were highlighted, including fostering relationships, physical health, accomplishment, mindset, meaning, environment, and engagement. Two additional themes that foster vitality included job autonomy and time away from work. Themes emerged that underscore how leaders utilize their vitality for followers, and the potentially detrimental impacts to leadership when leaders are drained.DiscussionOverall, results highlight the importance of vitality and self-care as critical for leaders’ ability to maximize their leadership performance.
The relationship between online learning self-efficacy, informal digital learning of English, and student engagement in online classes: the mediating role of social presence
Authors: Wu Ronglan 
Published: October 2023

IntroductionThis study investigates the interplay between Online Learning Self-Efficacy (OLSE), Informal Digital Learning of English (IDLE), student engagement in online classes, and the mediating effect of Social Presence (SP) among intermediate Chinese English as a Foreign Language (EFL) students. The research sample consisted of 389 participants enrolled in online English courses within a chain of language schools.MethodsData collection involved the use of validated scales to assess OLSE, IDLE, SP, and online student engagement. Structural Equation Modeling (SEM) was employed for data analysis.ResultsThe findings revealed direct influences of OLSE and SP on online student engagement. Additionally, IDLE exhibited a positive impact on online student engagement, with a partial mediation effect through SP. This suggests that informal digital English learning significantly contributes to students’ engagement in online classes, with this influence being facilitated by the sense of social presence experienced by students during virtual interactions.DiscussionThis research underscores the importance of OLSE, IDLE, and SP in shaping student engagement within online learning environments. The results highlight that fostering informal digital English learning can enhance students’ active participation in online courses, with SP serving as a key mediator in this relationship. These insights provide valuable guidance for educators and institutions seeking to improve student engagement in online educational settings.
Adolescent help-seeking: an exploration of associations with perceived cause of emotional distress
Authors: O'Neill Alisha , Stapley Emily , Rehman Ishba , Humphrey Neil 
Published: October 2023

BackgroundHelp-seeking is intrinsic to efforts to manage the onset, maintenance, or escalation of mental health difficulties during adolescence. However, our understanding of adolescent help-seeking remains somewhat nebulous. A greater comprehension of help-seeking behavior from the perspective of adolescents is needed. It is also prudent to explore help-seeking behavior in the context of perceived cause for emotional distress, particularly as causal beliefs have been found to influence help-seeking behavior in adults.ObjectivesThe present study sought to categorize adolescents' experiences of help-seeking, and to examine the extent to which these categories (or “types”) of help-seeking behavior are associated with their perceptions of causal factors for emotional distress.MethodsThe data for this study were drawn from interviews conducted as part of the HeadStart Learning Programme. The sample comprised of 32 young people aged 11–12 years. Ideal-type analysis, a qualitative form of person-centered analysis, was used to construct a typology of adolescent help-seeking. Participants' help-seeking “type” was then compared with their perceived cause for emotional distress “type.”FindingsWe developed four distinct categories of help-seeking: (1) guided by others who have taken notice; (2) skeptical with unmet needs; (3) motivated and solution focused; and (4) preference for self-regulation. Simultaneously, we identified principal associations between perceived cause of emotional distress—(1) perceived lack of control; (2) unfair treatment; (3) others: their actions and judgements as the catalyst; (4) concern for self and others; and (5) self as cause—and help-seeking approaches. “Perceived lack of control” was most likely to be associated with “others who have taken notice”; “Unfair treatment” with “skeptical with unmet needs”; “others: their actions and judgements as the catalyst” with “motivated and solution focused”; “concern for self and others' with ‘guided by others who have taken notice”; finally, “self as cause” was most likely to be associated with “preference for self-regulation.”ConclusionsThis study demonstrates meaningful and distinct categories of adolescent help-seeking and offers empirical evidence to support the assertion that perceived cause for emotional distress may influence the help-seeking approaches of adolescents.
Unmet needs for care for activities of daily living among older adults with functional disabilities in Vietnam
Authors: Phi Phong Manh , Giang Long Thanh , Pham Tham Thi Hong 
Published: October 2023

BackgroundGiven its low-middle-income status, Vietnam is experiencing a rapidly aging population. Along with this demographic trend, the care needs of older adults, particularly those with functional disabilities, have become an emerging policy issue.PurposeThis study examined the prevalence of unmet needs for care in activities of daily living (ADLs) among Vietnamese older adults with functional disabilities.MethodsWe used data from the Population Change and Family Planning Survey (PCS) in 2021, which was a nationally representative survey. Cross-tabulations and logistic regressions were applied to identify older adults' individual and household factors associated with their unmet care needs.ResultsOverall, 4.80% of older adults with at least one functional disability needing care to perform one or more ADLs suffered from unmet needs, of whom 2.32% did not receive any care and 3.05% received insufficient assistance. Logistic regression results revealed that age, sex, place of residence, ethnicity, marital status, education levels, and self-rated health were significantly associated with unmet needs. The higher risk of having unmet needs is associated with those in middle age (70–79), men, rural residents, ethnic minorities, currently unmarried people, those with less than a primary educational level, and those with normal or poor self-rated health.ConclusionAttention should be paid to vulnerable older adults, such as those living in rural areas with poor health status, in order to reduce their unmet needs for ADL assistance.
Update and validation of the Canadian Behavior, Attitude and Nutrition Knowledge Survey (C-BANKS 2.0)
Authors: Lafave Lynne M. Z. , Hayek Joyce , Lafave Mark R. 
Published: October 2023

AimUnderstanding knowledge, attitudes and behaviors related to nutrition is crucial in developing effective intervention strategies to promote healthy eating habits. This study revised and updated the Canadian Behavior, Attitude and Nutrition Knowledge Survey (C-BANKS) to align with the current Canada’s Food Guide and dietary guidance and report on its reliability and validity with a new population.MethodData from 167 early childhood educators were recruited to test the revised C-BANKS’ reliability and validity. Reliability, as measured by internal consistency, was assessed using Cronbach’s alpha, while concurrent validity was determined by correlating the C-BANKS 2.0 scores with the CHEERS (Creating Healthy Eating and Active Environments Survey) and Mindful Eating Questionnaire (MEQ). Responsiveness was assessed by comparing a baseline C-BANKS 2.0 score to a post-test score after completing an online healthy eating and physical activity educational intervention.ResultsThe adapted C-BANKS 2.0 questionnaire demonstrated good internal consistency (Cronbach’s alpha &gt;0.70) and construct validity with related measures CHEERS and MEQ (p &lt; 0.05). The C-BANKS 2.0 demonstrated strong responsiveness. Specifically, C-BANKS 2.0 scores increased after the nutrition education intervention (p &lt; 0.001). Additionally, there were no signs of floor or ceiling effects.ConclusionThe adapted C-BANKS 2.0 demonstrated satisfactory internal consistency, construct validity, and responsiveness to measure of nutrition knowledge, attitudes, and behaviors in an early childhood educator population. The revised C-BANKS 2.0 provides insight into the key factors that influence dietary habits thereby informing the design and evaluation of effective nutrition community intervention programs.
Multiple social identities cloud norm perception: responses to COVID-19 among university aged Republicans and Democrats
Authors: Krupka Erin , Hoover Hanna , Eckel Catherine , Rosenblat Tanya , Ojumu Oluwagbemiga , Wilson Rick K. 
Published: October 2023

IntroductionMost work on social identity, defined as one's sense of self derived from membership to social groups, focuses on a single identity and its behavioral consequences. But a central insight of social identity theory is that people belong to multiple social groups, derive self-esteem from multiple identities and care to conform to the norms for those identities. However, very little work has turned its attention to understanding when and how multiple social identities interact. We motivate hypotheses with a framework that extends a social identity model to include multiple identities.MethodsUsing a longitudinal sample (N &gt; 600) of university students located primarily in Texas and throughout the US, we use university social identity, and the associated university norms, to characterize COVID related social distancing norms between April and October of 2020 and then unpack how another identity, the student's political identity, impacts perception of those norms.ResultsDespite incentives to do otherwise, we find that beliefs about university norms differ depending on the respondent's political identity. We interpret this as a spillover effect of attitudes from one identity to another.DiscussionWe relate our results back to a model of social identity, to the literature on spillovers where such psychological spillovers are hard to empirically identify, and to methods for future work on identity and spillovers.
The symptomatology and diagnosis of domoic acid toxicosis in stranded California sea lions (Zalophus californianus): a review and evaluation of 20 years of cases to guide prognosis
Authors: McClain Abby M. , Field Cara L. , Norris Tenaya A. , Borremans Benny , Duignan Pàdraig J. , Johnson Shawn P. , Whoriskey Sophie T. , Thompson-Barbosa Lorraine , Gulland Frances M. D. 
Published: October 2023

IntroductionDomoic acid (DA) is a glutaminergic excitatory neurotoxin that causes the morbidity and mortality of California sea lions (Zalophus californianus; CSL) and other marine mammals due to a suite of effects mostly on the nervous and cardiac systems. Between 1998 and 2019, 11,737 live-stranded CSL were admitted to The Marine Mammal Center (TMMC; Sausalito, CA, USA), over 2,000 of which were intoxicated by DA. A plethora of clinical research has been performed over the past 20 years to characterize the range of toxic effects of DA exposure on CSLs, generating the largest dataset on the effects of natural exposure to this toxin in wildlife.Materials and methodsIn this study, we review published methods for diagnosing DA intoxication, clinical presentation, and treatment of DA-intoxicated CSL and present a practical, reproducible scoring system called the neuroscore (NS) to help assess whether a DA-affected CSL is fit for release to the wild following rehabilitation. Logistic regression models were used to assess the relationships between outcome (released vs. euthanized or died) and multiple variables to predict the outcome for a subset of 92 stranded CSLs.ResultsThe largest proportion of DA-intoxicated CSLs was adult females (58.6%). The proportions of acute and chronic cases were 63.5 and 36.5% respectively, with 44% of affected CSL released and 56% either dying naturally or euthanized. The average time in rehabilitation was 15.9 days (range 0–169) for all outcomes. The best-performing model (85% accuracy; area under the curve = 0.90) assessing the relationship between outcome and predictor variables consisted of four variables: final NS, change in NS over time, whether the animal began eating in rehabilitation, and the state of nutrition on admission.DiscussionOur results provide longitudinal information on the symptomatology of CSL intoxicated by domoic acid and suggest that a behavioral scoring system is a useful tool to assess the fitness for the release of DA-intoxicated CSL.
Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study
Authors: Wang Ye , Jin Zibin , Xu Wenli , Chen Keyu , Wei Lingxin , Yang Dong , Deng Xiaoming , Tong Shiyi 
Published: October 2023

Purpose: Dexmedetomidine exerts a sedative effect by promoting the sleep pathway endogenously and producing a state similar to N2 sleep. This study aimed to study the efficacy and safety of dexmedetomidine nasal spray in the treatment of postoperative sleep disturbance.Methods: This study enrolled 120 participants [men and women; age, 18–40 years; American Society of Anesthesiologists grade, I or II] who underwent maxillofacial surgery under general anesthesia through nasotracheal intubation. The participants were randomly divided into three groups: blank control group (BC group), 1.0 μg/kg dexmedetomidine group (1.0 Dex group), and 1.5 μg/kg dexmedetomidine group (1.5 Dex group), with 40 patients allocated to each group. At 21:30 on the night after the operation, the intervention groups were administered their corresponding doses of dexmedetomidine nasal spray. The Pittsburgh Sleep Quality Index (PSQI) scale was used to evaluate the baseline sleep status of participants 1 month preoperatively and on the night after the operation. Polysomnography (PSG) was used to record the sleep status on the night after the operation. We recorded the rescue times of sedative and analgesic drugs on the first night after surgery, adverse reactions, total hospital stay duration, and total costs.Results: Compared with patients in the BC group, those in 1.0 Dex and 1.5 Dex groups had longer N2 sleep duration, were awake for a shorter time after dose administration, woke up less often, and had significantly improved sleep efficiency (p &lt; 0.05). Compared with the BC group, the PSQI scores of 1.0 Dex and 1.5 Dex groups were significantly lower on the night after operation, and the proportion of PSQI &gt; 5 was significantly lower (p &lt; 0.05). Compared with patients in the BC group and the 1.0 Dex group, those in the 1.5 Dex group had significantly prolonged N3 sleep, reduced frequency of requiring sufentanil rescue, lower incidence of sore throat after surgery, and shorter average length of hospital stay (all, p &lt; 0.05).Conclusion: The sleep quality of participants on the night after having undergone maxillofacial surgery was safely and effectively improved by 1.0–1.5 μg/kg dexmedetomidine atomized nasal sprays. Notably, only the latter could prolong N3 sleep. Level of Evidence II: Evidence was obtained from at least one properly designed randomized controlled trial.
Rhizosphere Bacterial Isolation from Indigenous Plants in Arid and Semi-Arid Algerian Soils: Implications for Plant Growth Enhancement
Authors: Novello Giorgia , Bona Elisa , Toumatia Omrane , Vuolo Francesco , Bouras Noureddine , Titouah Houda , Zitouni Abdelghani , Gorrasi Susanna , Massa Nadia , Cesaro Patrizia , Todeschini Valeria , Lingua Guido , Gamalero Elisa 
Published: October 2023

The Mediterranean area is one of the geographic zones most affected by land degradation and desertification and these conditions appear to be even more exacerbated by climate change. Based on this idea, this work aimed to isolate, identify, characterize, and select bacterial strains able to tolerate salinity and drought, which could possibly be used in agriculture as plant biofertilizers. The sampling of rhizosphere soil was performed in two Algerian regions, Ghardaïa and Djelfa (arid and semi-arid zones, respectively) in six provinces, targeting fourteen native plant species, known for their therapeutic use. A total of 288 bacterial strains were isolated, identified, and characterized for their growth at different temperatures and salt tolerance. Based on these capabilities, 95 isolates were selected. These strains underwent further evaluation for their plant-beneficial traits, including siderophore synthesis, auxin production, and phosphate solubilization. Additionally, we assessed their impact on tomato, cucumber, and sorghum seed germination. In a final screening step, nine bacterial strains were tested for their potential plant growth-promoting activity on tomato plants grown in semi-controlled conditions. Our results demonstrated that three strains (Bacillus simplex AH24, Microbacterium arborescens PU10, and Microbacterium paludicola AEA23) showed plant growth promotion activities on tomato.
Budidaya Kepiting Bakau (Scylla Serrata) Teknologi Apartemen Sistem Resirkulasi Desa Cot Lamkuweueh, Kota Banda Aceh
Authors: Akbar Said Ali , Putra Dedi Fazriansyah , Rusydi Ichsan 
Published: October 2023

It is one of the important and potential economic products of Aceh province. Wild crabs have great potential and prospects for aquaculture development. This can be seen from the large number of ponds in Banda Aceh city. Currently, the mangrove crab farming model using a floating cage system is the most popular in Aceh. The problem is that natural conditions cannot be controlled, so water quality changes drastically, making it difficult for farming to achieve success above 80%. Syiah Kuala University Aquaculture Research Program Community Services Group has developed a mangrove crab farming unit with a vertical apartment system equipped with a water circulation system or RAS. The apartment system is designed with 4 floors, each floor has 10 crab boxes. The time it takes for crabs to molt during spawning is 15-20 days with a survival rate of 80-90%. Hopefully this technology transfer to partners will become an educational model for mangrove crab farmers in Cot Lamkuweueh village, Banda Aceh city.