bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and properties of alcohol‐resistant thermal transfer printing inks for multifunctional label printing via physical blending of resins
Authors: Luo Zhuo , Chen Guangyu , Yang Yuanhao , Huang Liuqing , Zhang Chentong , Luo Haixiang , Yu Weiwei , Luo Xuetao 
Published: November 2023

AbstractDue to the rise of the logistics industry and the widespread use of ink labels, problems such as the narrow operating temperature range of ink, poor alcohol resistance, and insufficient scratch resistance need to be solved urgently. In this work, creates alcohol‐resistant thermal transfer inks by mixing polypropylene chloride (VP‐365) and epoxidized hydrogenated bisphenol A (P) resin and incorporating them into the ink formulation. The synthetic ink has a lower glass transition temperature (118.2°C), allowing the ink to print at lower temperatures. It has small wetting angles (68°, 63°, 58°, 46°, and 40°) and a large adhesion force (10.44 – 14.4 N) for different labels. Further, to evaluate the printing performance of the ink, the ink was scratched under 1000 g pressure and in the environment of isopropyl alcohol to evaluate its printing performance. The produced ink has high scratch resistance (300 times) and good alcohol resistance (140 times). Moreover, the developed ink showed good printability, printing media versatility, high adhesion, and excellent alcohol resistance. The synthesis method is facile and cost‐effective, which paves a novel way towards high‐performance ink printing and thermal transfer technology industries.
Study of long‐term skid and wear resistance of waterborne epoxy resin‐SBRcompound modified emulsified asphalt microsurfacing
Authors: Lu Chuan , Zheng Mulian , Gao Yuan , Ding Xiaoyan , Zhang Wenwu , Chen Wang 
Published: November 2023

AbstractAs an eco‐friendly technology for pavement preventive maintenance, microsurfacing (MS) has the potential properties of cost‐saving and excellent performance benefits in repairing distress. MS also improves the surface function, especially skid resistance, of old pavements that have gradually decayed under the coupled effects of long‐term environment and loads. Reasonable assessments of the long‐term skid and wear resistance of the MS can provide support for accurate decision‐making on preventive maintenance, which in turn reduces maintenance costs and saves maintenance costs, and ensures traffic safety. To evaluate the long‐term skid and wear resistance of MS in different natural and traffic environments, this paper investigated the change of British pendulum number (BPN), rutting depth, and mass loss rate of waterborne epoxy resin‐SBR compound emulsified asphalt micro‐surfacing (WER‐SBR MEAMS) under different environmental factors and traffic conditions based on the self‐developed accelerated loading abrasion instrument. The factors considered in the experiment include temperature, rainfall, UV radiation, speed, and load. The results showed that temperature and vehicle speed had a detrimental effect on the durability of WER‐SBR MEAMS, which was more pronounced after 10,000 wear loading cycles. Reducing immersion time and slowing down the aging rate can improve the durability of WER‐SBR MEAMS. Further, the influence degrees of different factors on the skid and wear resistance of MS were evaluated using the gray correlation method. From the results of the gray correlation analysis, the correlation coefficients between external variables and BPN, rutting depth, and mass loss rate are all greater than 0.8, which indicate that all the variables involved have relatively obvious and regular effects on the skid and wear resistance of WER‐SBR MEAMS.
Magnesium oxide synthesized with Alpinia zerumbet leaf extracts as a sustainable alternative to zinc oxide in nitrile rubber compounds: A comparative vulcanization kinetics investigation
Authors: da Silva Arianne A. , de Souza Marcelo A. V. , F de Sousa Ana Maria , Carvalho Nakédia M. F. , Furtado Cristina R. G. 
Published: November 2023

AbstractZinc oxide (ZnO) is the most widely used activator in the rubber industry; however, there is growing concern about its use as it can become toxic to the environment, particularly in aquatic systems. This study describes the synthesis of magnesium oxide (MgO) assisted by the Alpinia zerumbet extract, which is then used as an activator in the replacement of ZnO to vulcanize nitrile rubber (NBR) containing 33% and 45% acrylonitrile (ACN). The t90 for NBR‐33% and NBR‐45% are 20 and 15 min, respectively. This indicates a reduction of 5 min in t90 with an increase in ACN. In comparison, ZnO‐activated NBR compounds exhibit the opposite trend, with t90 increasing from 10 for NBR‐33% to 19 min for NBR‐45%. Furthermore, the decrease in activation energy (Ea) with the increase in conversion for 33%‐MgO and 45%‐MgO indicates that vulcanization with MgO is a complex process. This behavior is comparable to that of 45%‐ZnO, but not for 33%‐ZnO because its Ea remains oscillating at 80–90 kJ mol−1 in the entire conversion range. The crosslink densities of 33%‐MgO and 45%‐MgO are 5.87 and 4.78 mol cm−3, respectively. These values are slightly higher than those for 33%‐ZnO (5.77 mol cm−3) and 45%‐ZnO (4.38 mol cm−3).
Heavy Tetrel Clusters Based on the Bicyclobutane Framework: Bicyclo[1.1.0]butanes, [1.1.1]Propellanes, and Tricyclo[2.1.0.02,5]pentanes
Authors: Ya. Lee Vladimir , Gapurenko Olga A. 
Published: November 2023

AbstractIn this review, the current state of affairs in the novel field of the group 14 element clusters based on the bicyclo[1.1.0]butane framework, namely, bicyclo[1.1.0]butane, [1.1.1]propellane, and tricyclo[2.1.0.02,5]pentane derivatives, are overviewed. Structural similarities and differences between these three classes of highly strained polycyclic compounds are considered from the viewpoint of the critically important nature of their bridgehead bonds. Synthetic strategies towards bicyclo[1.1.0]butanes, [1.1.1]propellanes, and tricyclo[2.1.0.02,5]pentanes, as well as their peculiar structural and bonding features, and specific reactivity, are also presented and discussed in this review.
Prolonged neural encoding of visual information in autism
Authors: Marsicano Gianluca , Casartelli Luca , Federici Alessandra , Bertoni Sara , Vignali Lorenzo , Molteni Massimo , Facoetti Andrea , Ronconi Luca 
Published: November 2023

AbstractAutism spectrum disorder (ASD) is associated with a hyper‐focused visual attentional style, impacting higher‐order social and affective domains. The understanding of such peculiarity can benefit from the use of multivariate pattern analysis (MVPA) of high‐resolution electroencephalography (EEG) data, which has proved to be a powerful technique to investigate the hidden neural dynamics orchestrating sensory and cognitive processes. Here, we recorded EEG in typically developing (TD) children and in children with ASD during a visuo‐spatial attentional task where attention was exogenously captured by a small (zoom‐in) or large (zoom‐out) cue in the visual field before the appearance of a target at different eccentricities. MVPA was performed both in the cue‐locked period, to reveal potential differences in the modulation of the attentional focus, and in the target‐locked period, to reveal potential cascade effects on stimulus processing. Cue‐locked MVPA revealed that while in the TD group the pattern of neural activity contained information about the cue mainly before the target appearance, the ASD group showed a temporally sustained and topographically diffuse significant decoding of the cue neural response even after the target onset, suggesting a delayed extinction of cue‐related neural activity. Crucially, this delayed extinction positively correlated with behavioral measures of attentional hyperfocusing. Results of target‐locked MVPA were coherent with a hyper‐focused attentional profile, highlighting an earlier and stronger decoding of target neural responses in small cue trials in the ASD group. The present findings document a spatially and temporally overrepresented encoding of visual information in ASD, which can constitute one of the main reasons behind their peculiar cognitive style.
Einfluss der Bügelschlösser auf das Tragverhalten von Stahlbetonstützen
Authors: Matz Henrik , Empelmann Martin 
Published: November 2023

AbstractZur Sicherung der Integrität eines Gesamttragwerks sollten Stahlbetonstützen nach Erreichen ihrer Traglast noch eine definierte Resttragfähigkeit bzw. Robustheit aufweisen. Ein robustes Nachbruchverhalten kann z. B. durch eine geeignete konstruktive Durchbildung erzielt werden. Hierbei wird der Einfluss der Bügelschlösser häufig unterschätzt und baupraktischen Belangen untergeordnet. Im vorliegenden Beitrag wird dieser Aspekt experimentell untersucht. Durchgeführte Stützenversuche zeigen deutlich, dass die Ausbildung der Bügelschlösser einen maßgeblichen Einfluss auf das Nachbruchverhalten von Stahlbetonstützen hat und die Regelungen des EC2 sowie die verschiedenen Empfehlungen der kommentierten Fassung nicht zu einem gleichartigen Verhalten führen.
Improved adeno‐associated virus empty and full capsid separation using weak partitioning multi‐column AEX chromatography
Authors: Di Wenjun , Koczera Kyle , Zhang Peilun , Chen Dennis P. , Warren James C. , Huang Chao 
Published: November 2023

AbstractRecombinant adeno‐associated virus (rAAV) empty and full capsid separation has been a topic of interest in the rAAV gene therapy community for many years and the anion exchange chromatography (AEX) step has undergone various process optimizations to improve rAAV empty capsid separation, including AEX stationary phase, mobile phase, and process parameters. Here, we present a new AEX method that employs both weak partitioning chromatography (WPC) and multi‐column chromatography (MCC) to achieve improved full rAAV percentage in the AEX pool. The WPC technology allows empty rAAV to be displaced by full rAAV during loading, while the MCC technology enables parallel column processing which further increases AEX step productivity. Our results show that, compared to baseline AEX batch chromatography, the AEX‐WPC‐MCC method demonstrated improvements in both AEX pool full rAAV percentage (∼ 20% increase) and rAAV genome recovery (∼ 20% increase). As a result, the productivity (full capsid generated per liter of AEX column per hour of processing time) of the AEX step increased by ∼34‐fold from the baseline AEX batch run to the AEX‐WPC‐MCC run. It is foreseeable that this AEX‐WPC‐MCC method could find applications in large‐scale rAAV manufacturing processes to improve AEX yield and reduce the cost of goods of rAAV manufacturing.
Joining multi‐stakeholder initiatives to fight climate change: The environmental impact of corporate participation in the Science Based Targets initiative
Authors: Romito Stefano , Vurro Clodia , Pogutz Stefano 
Published: November 2023

AbstractThis study theorizes and empirically tests whether firms' decisions to join multi‐stakeholder initiatives, targeting climate mitigation, lead to improved environmental performance. We focus on firms' participations in the Science Based Targets initiative, a multi‐stakeholder initiative meant to support firms in setting greenhouse gas (GHG) emission reduction targets in line with the thresholds defined by the Paris Agreement in 2015. The study hypothesizes that participation reduces firm's concerns about uncertainty and encourages investments in timeous internal climate change activities. We used the coarsened exact matching methodology to create a matched sample of European and North American listed firms participating in the initiative and comparable, non‐participating firms over a 3‐year period from 2015 to 2017. The results showed that firms' participation led to lower levels of GHG emissions compared to similar non‐participating counterparts, especially when they committed to the initiative with the intention to follow the proposed indications.
Managing integrated continuous bioprocesses in real time: Deviations in product quality
Authors: Grampp Gustavo , Bosley Allen , Qadan Maen , Schiel John , Spasoff Andy , Valax Pascal , Schaefer Gene 
Published: November 2023

AbstractThe N‐mAb case study was produced by the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) to support teaching and learning for both industry and regulators around adoption of advanced manufacturing process technologies such as integrated continuous bioprocesses (ICB) for monoclonal antibodies (mAbs). N‐mAb presents the evolution of an integrated control strategy, from early clinical through process validation and commercial manufacturing with a focus on elements that are unique to ICB. The entire N‐mAb case study is quite comprehensive, therefore this publication presents a summary of the chapter on managing deviations from a state of control in real time. This topic is of critical importance to ICB and is also applicable to batch processes operated at a rapid cadence.
Chemical Characterization, DNA‐Damage Protection, Antiproliferative Activity and in Silico Studies of the Essential Oils from Perralderia coronopifolia Coss.**
Authors: Boussaha Sara , Lassed Somia , Abdelwahab Ahmed B. , Krid Adel , Altun Muhammed , Chalard Pr.Pierre , Chalchat Pr.Jean Claude , Figueredo Gilles , Zama Pr.Djamila , Demirtas Pr.Ibrahim , Benayache Pr.Samir , Benayache Pr.Fadila 
Published: November 2023

AbstractIn this study, for the first time, we analyzed the chemical composition of essential oils (EOs) steam‐distilled from the flowers and leaves of Perralderia coronopifolia by GC‐FID/MS. The objective was to explore new anticancer and antioxidant bioactive substances and understand their mechanisms of action through the use of plant‐derived natural products. The major chemical components characterizing the EOs were cis‐chrysanthenyl acetate 1, 6‐oxocyclonerolidol 2, cis‐8‐acetoxychrysanthenyl acetate 3, and 6α‐hydroxycyclonerolidol 4, respectively. Furthermore, the EOs inhibited cell proliferation in HeLa (human cervix carcinoma) and PC3 (human prostate cancer) cells and protected plasmid DNA from oxidative damage caused by UV‐photolyzed H2O2. Employing a molecular docking study, we elucidated the main compounds′ inhibition mechanisms. Consequently, the antitumor activity could be related to the inhibitory property of compound 3 against CDC25B phosphatase. The evaluation of ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties and the density functional theory (DFT) calculations of the major compounds, especially compound 3, offer potential insights for designing and developing new cancer drug candidates. In conclusion, our study provides a framework for future research and development in the field by establishing a scientific foundation for the use of Perralderia coronopifolia essential oils as a prospective source of antioxidant and anticancer agents.
Prenatal sirenomelia diagnosis in the first trimester: A case report and literature review
Authors: Shi Xiaqing , Kong Fengbei , Wu Guoru , Shi Yu 
Published: November 2023

Key Clinical MessageSirenomelia is a lethal condition in the perinatal period. The sonographic examination in the first trimester can effectively detect sirenomelia with a high degree of accuracy. Furthermore, vascular examinations using color flow imaging and augmented imaging techniques such as 3D sonography can improve diagnostic accuracy. Parents should get advice from a multidisciplinary team concerning sirenomelia care and prognosis as soon as possible.AbstractSirenomelia is a rare condition with an uncommon congenital malformation; its most remarkable feature is lower extremity fusion with multiple visceral anomalies. Accordingly, the appearance resembles a mermaid's tail, hence mermaid syndrome. Sirenomelia has an incidence rate of 1.5–4.2 per 100,000 births, a male‐to‐female 2.7:1 ratio, and shows no differences across races. The condition is generally associated with renal agenesis, exterior genitalia defects, a single umbilical artery, and an imperforate anus. Here, we describe the first sirenomelia case in our hospital; a 13‐week‐old fetus with conjoined lower limbs was identified by ultrasound in the first trimester. We discuss this rare case with reference to the literature and provide insights on diagnosing this condition by ultrasound.
Isolated breast hydatid cyst: A case report
Authors: Mesfin Telila , Sahiledengle Biniyam , Taha Muhammadamin , Nigusu Fikadu , Seyoum Kenbon , Geta Girma , Ejigu Neway , Zenbaba Demisu , Gomora Degefa , Beressa Girma , Dadi Sisay , Ibrahim Elias , Tsegaye Mesfin , Kusa Getu , Bezaw Elias 
Published: November 2023

Key Clinical MessageA hydatid cyst is a parasitic infestation most frequently caused by the larval tapeworm known as Echinococcus granulosus. Breast hydatidosis is a very uncommon condition that may be the main site or one of its components in cases of extensive hydatidosis. We discussed a 28‐year‐old female patient who had been experiencing left breast pain for a year prior to her presentation.
Metabolic alkalosis masked presentation of diabetic ketoacidosis: A case report
Authors: Wuttiputhanun Thunyatorn , Townamchai Natavudh , Eiam‐Ong Somchai , Takkavatakarn Kullaya 
Published: November 2023

Key Clinical MessageManaging mixed acid–base disorders can be diagnostically challenging, particularly when metabolic acidosis and metabolic alkalosis occur simultaneously. When dealing with metabolic alkalosis, a comprehensive approach involves taking a detailed medical history, assessing volume status, and performing urine chloride analysis. Routine calculation of the anion gap is important to identify masked wide anion gap metabolic acidosis. We report a case of a 32‐year‐old female with type 1 diabetes mellitus, presented with intractable vomiting for 2 days with hyperglycemia, hypokalemia, and metabolic alkalosis, along with a wide anion gap. She was diagnosed with “diabetic ketoalkalosis” due to diabetic ketoacidosis combined with vomiting‐induced metabolic alkalosis. She became clinically stable after resuscitation with normal saline, intravenous potassium, and intravenous insulin.
Intramuscular cavernous malformation in the temporalis muscle: Diagnosis and treatment of a rare tumor in a rare site
Authors: Jafarian Mohammad , Alizadeh Tabrizi Mohammad Amir , Mashhadi Abbas Fatemeh , Torabi Zahra Sadat 
Published: November 2023

Key clinical messageIn this case report we present a very rare case of intramuscular cavernous hemangioma in the temporalis muscle which was successfully managed with surgical excision with no evidence of recurrence in follow‐up.
Hashimoto thyroiditis in a lingual thyroid: An interesting case
Authors: Dahal Prajwal , Parajuli Sabina 
Published: November 2023

Key Clinical MessageWhenever an enlarging mass is seen in throat, possibility of lingual thyroid should be considered. Thyroid function test should be done whenever ectopic thyroid is detected. Imaging (ultrasonography or Tc‐99m scintigraphy) is adequate for diagnosis. Conservative treatment with levothyroxine helps in reducing size of lingual thyroid.AbstractHashimoto thyroiditis in lingual thyroid results in enlargement of the thyroid gland and oropharyngeal symptoms. Suppression therapy with levothyroxine results in reduction in size of the gland. We present an interesting case of Hashimoto disease in an adolescent female presenting as oropharyngeal mass.
Insight into the Role of the Amino‐Organosilane Modifier in Improving the Catalytic Activity of ZnO‐Supported Gold Species in Base‐Free Oxidation of Benzyl Alcohol
Authors: Wolski Lukasz , Sobańska Kamila , Wolska Joanna , Rozmyślak Mateusz , Nowaczyk Grzegorz , Frankowski Marcin , Pietrzyk Piotr 
Published: November 2023

AbstractUnderstanding the factors that affect the reactivity of gold nanoparticles (Au NPs) in the catalytic oxidation of organic compounds remains an important issue. Of particular significance is tuning the effect of metal‐support interaction toward improving the catalytic performance of Au NPs. The main goal of this study is to provide new insight into the role of the amino‐organosilane (APMS) modifier, used for anchoring of gold species on ZnO support, in controlling the reactivity of Au NPs in H2O2 activation and the subsequent catalytic oxidation of benzyl alcohol. This study reveals that APMS modifier weakens the electronic interaction between ZnO and Au NPs, leading to a lower catalase‐like activity toward H2O2 in comparison to that observed for modifier‐free gold catalyst of similar size of nanoparticles. As a result, a slower rate of oxygen evolution resulted in higher activity in the oxidation of benzyl alcohol and enabled more efficient utilization of H2O2 under base‐free conditions. No radical species were formed during the oxidation reaction, and molecular oxygen formed in situ in the reaction medium was the primary oxidant responsible for the catalytic conversion of benzyl alcohol.
NDI based C2‐symmetric Chiral Supramolecular Hydrogels Towards Enhanced Conductivity
Authors: Razaq Hamaela , Mehwish Nabila , Xia Jingyi , Feng Chuanliang 
Published: November 2023

AbstractTo comprehend the significance of improved conductive properties in C2‐symmetric hydrogels, it is vital to investigate how non‐gelating achiral functional group isomers influence the conductivity of such supramolecular hydrogels, whereas understanding the major driving forces behind this regulatory process is first and foremost. Herein, we report a hydrogel system containing tryptophan‐conjugated NDI as the backbone (L/D‐NTrp), enabling effective supramolecular assembly with the bipyridyl functional group isomers. This co‐assembly behavior results in materials with exceptional mechanical properties and high conductivities, surpassing most previously reported C2‐symmetrical hydrogels, as well as the ability to form controlled morphologies. Notably, the co‐hydrogels displayed an eight‐fold increase in mechanical strength, making them more robust and resistant to deformation compared to the original gel. Additionally, all hydrogels exhibited favorable electrical conductivity, with the co‐assembled hydrogels showcasing notable performance, making them a promising candidate for use in electronic devices and sensors. This report lays the foundation for further investigation into the properties and potential applications of L/D‐NTrp compound in the range of fields, including drug delivery, tissue engineering, and electronics.
A meta‐analysis investigating the efficacy and adverse events linked to sacubitril‐valsartan in various heart failure subtypes
Authors: Ji Qing 
Published: November 2023

AbstractBackgroundSacubitril‐valsartan, an inhibitor of the angiotensin receptor neprilysin (ARNi), has been purported to exhibit superiority over angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in individuals diagnosed with heart failure.HypothesisThis paper gives an updated meta‐analysis comparing the efficacy and safety of sacubitril‐valsartan to that of standard treatment for different types of heart failure.ResultsThe meta‐analysis comprised a total of nine randomized controlled trials (RCTs), incorporating data from a substantial sample size of 15 939 patients. The study observed a decrease in overall mortality and mortality related to cardiovascular causes among patients in the heart failure with reduced ejection fraction (HFrEF) category who were treated with sacubitril‐valsartan. However, no statistically significant variation in this outcome was seen among patients with heart failure with preserved ejection fraction and HFmrEF. Patients who were administered sacubitril‐valsartan had a notably elevated likelihood of experiencing hypotension. Nevertheless, no significant disparities were observed in terms of other adverse events among the various treatment groups.ConclusionCurrent meta‐analysis provide support for use of sacubitril‐valsartan in decreasing mortality in patients with HFrEF. However, more numbers of studies are required to draw a definite conclusion on other benefits associated with sacubitril‐valsartan use over standard treatment of ACE inhibitors and ARBs.