bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring disproportional use of exclusionary punitive practices by disability group: Evidence of higher disproportionality in low‐SES Chilean students with ADHD
Authors: López Verónica , Allende Claudio , Bosch Christina , Ortiz‐Mallegas Sebastián , Valenzuela Juan Pablo , González Luis 
Published: November 2023

AbstractAlthough inclusive education policies conflict with punitive discipline measures, inclusion in mainstream schools may coexist with or allow such exclusionary punitive discipline. In Latin America, however, there is scarce research on how punitive measures are distributed, and if and how they affect students with disabilities enrolled in regular school settings. The purpose of this study was to characterize the occurrence of punitive exclusionary practices among students with disabilities enrolled in mainstream schools. We analysed reports from a national sample of Chilean students (N = 447,697) and parents on the frequency of punitive exclusionary discipline practices to identify the contribution of individual, classroom and school factors to student exclusion from general education settings. Individual characteristics included different disability groups. Multilevel logistic regression results consistently showed that students with ADHD were more likely to receive disciplinary exclusions, both in primary and in high school, with an odds‐ratio increase from 30% to nearly 150%, with higher rates for low‐SES students with ADHD. These findings suggest that in Chile, student‐level factors of gender, class and disability are strongly associated with exclusionary punitive discipline in schools. We discuss the intersectional dynamics of gender, class, race and disability in disciplinary processes of exclusion.
Forensic odontology in DVI—A path forward
Authors: Wood Robert E. , Gardner Taylor 
Published: November 2023

AbstractDental identification is a pillar of disaster victim identification (DVI). Dental identification is accurate, efficient, inexpensive, and accepted in courts of law. The (known) antemortem (AM) dental charts and radiographic images acquired from the dentist of the missing person are evaluated, processed, and compared to post mortem (PM) findings present in the dentition or fragments of the dentition of the deceased individual. These comparisons evaluate and assess individuating restorative dental work, dental anatomical areas of concordance, spatial relationships of teeth one to another, and occasionally calculate the degree of “uniqueness” of either or both of the AM and PM dentition compared to known population databases. In a multiple fatality incident, odontologists may utilize age stratification to assist other means of identification. Computer comparison algorithms using recorded data can indicate possible matches between AM and PM data sets. Following clinical assessment, collection of post mortem tooth specimens for DNA profiling generation may be undertaken. This paper will highlight modern and efficient use of these tools. The framework for how dental identification in these incidents is currently managed is presented. The authors propose a change to this approach that moves away from interpretive subjective assessment toward comparisons based largely on objective data. The aim of this paper is to highlight the benefits of minimizing subjective decisions and maximizing objective data in the dental DVI process while simultaneously reducing risk to clinical personnel and minimizing costs by reducing the number of clinicians required onsite.
Unravelling the enigma of the human microbiome: Evolution and selection of sequencing technologies
Authors: Yi Xin , Lu Hong , Liu Xiang , He Junyi , Li Bing , Wang Zhelong , Zhao Yujing , Zhang Xinri , Yu Xiao 
Published: November 2023

AbstractThe human microbiome plays a crucial role in maintaining health, with advances in high‐throughput sequencing technology and reduced sequencing costs triggering a surge in microbiome research. Microbiome studies generally incorporate five key phases: design, sampling, sequencing, analysis, and reporting, with sequencing strategy being a crucial step offering numerous options. Present mainstream sequencing strategies include Amplicon sequencing, Metagenomic Next‐Generation Sequencing (mNGS), and Targeted Next‐Generation Sequencing (tNGS). Two innovative technologies recently emerged, namely MobiMicrobe high‐throughput microbial single‐cell genome sequencing technology and 2bRAD‐M simplified metagenomic sequencing technology, compensate for the limitations of mainstream technologies, each boasting unique core strengths. This paper reviews the basic principles and processes of these three mainstream and two novel microbiological technologies, aiding readers in understanding the benefits and drawbacks of different technologies, thereby guiding the selection of the most suitable method for their research endeavours.
ESG, financial constraint and financing activities: A study in the Chinese market
Authors: Guo Xuejing , Li Shi , Song Xiaoping , Tang Zilin 
Published: November 2023

AbstractThis paper investigates the impact of Chinese firms' environmental, social, and governance (ESG) performance on their financial constraint and financing activities. We find a negative association between firms' ESG performance and their financial constraint driven by the Chinese government's commitment to tackling climate change. Compared with state‐owned enterprises (SOEs), non‐SOEs have alleviated their financial constraint through both equity and debt issuance, thanks to the stock price appreciation and green credit. High‐pollution firms benefit from both equity and debt issuance, while low‐pollution firms mainly finance through equity issuance. Our findings demonstrate the leading role of the Chinese government in its domestic capital markets.
Alcohol initiation before age 15 predicts earlier hazardous drinking: A survival analysis of a 7‐year prospective longitudinal cohort of Australian adolescents
Authors: Gardner Lauren A. , Stockings Emily , Champion Katrina E. , Mather Marius , Newton Nicola C. 
Published: November 2023

AbstractBackground and aimsEarly alcohol use may predict later alcohol problems, but the magnitude of this effect and impact of delayed onset remain uncertain. This study measured age‐based differences in progression from first full alcoholic drink to hazardous drinking in one of the largest and most recent prospective cohorts of Australian adolescents.Design, settings, participants and measurementA 7‐year (2012–19) prospective longitudinal cohort of 2082 Australian adolescents was established from the Climate and Preventure (cohort 1) and Climate Schools Combined (cohort 2) studies. Participants completed surveys annually from ages 13 to 20 years. Interval censored survival analyses were conducted with first episode of hazardous drinking [three or more on proxy Alcohol Use Disorders Identification Test (AUDIT‐C)] as the survival end‐point, controlling for age, sex and mental health symptomatology. Onset of hazardous drinking was expressed as hazard ratios (HRs), and median survival time (years) was used to model first onset of hazardous alcohol use in survival curves.FindingsCompared with those aged 15 or older, those who had their first full drink at 12 or younger had significantly elevated risk of hazardous drinking onset during the study period [log (HR): 9.3; 95% confidence interval (CI) = 7.0–12.0, P < 0.001]. Compared with those who had their first full drink at ages 13–14, those who delayed until 15 or older had significantly later onset of hazardous drinking; 1.63 years for males (95% CI = 1.31–1.92, P < 0.001) and 1.50 for females (95% CI = 1.15–1.81, P < 0.001), resulting in a median age of onset of hazardous drinking of > 19 for both sexes (male: 19.05 years, 95% CI = 18.74–19.38; female: 19.47 years, 95% CI = 19.19–19.75). First drink at ages 13–14 was associated with the earliest onset of hazardous drinking (males: 17.43 years; females: 17.98 years).ConclusionsIn Australia, alcohol initiation prior to age 15 appears to be associated with an earlier onset of hazardous drinking than initiation after age 15.
Understorey vegetation moderates climate in open forests: The role of the skirt‐forming grass tree Xanthorrhoea semiplana F.Muell
Authors: Kok Xiangning , Bruns Liene , Guerin Greg , Keppel Gunnar 
Published: November 2023

AbstractMicrosites are created by abiotic and biotic features of the landscape and may provide essential habitats for the persistence of biota. Forest canopies and understorey plants may moderate wind and solar radiation to create microclimatic conditions that differ considerably from regional climates. Skirt‐forming plants, where senescent leaves create hut‐like cavities around the stem, create microsites that are sheltered from ambient conditions and extreme weather events, constituting potential refuges for wildlife. We investigate day and night temperatures and humidity for four locations (grass tree cavities, soil, 20 cm above‐ground, 1 m above‐ground) in a South Australian forest with relatively open canopy of stringybark eucalypts (Eucalyptus baxteri, E. obliqua) and an understorey of skirt‐forming grass trees (Xanthorrhoea semiplana) at 5, 10, 20, and 40 m from the forest edge. We also measured the percentage of canopy and understorey covers. Generally, temperature and humidity differed significantly between more sheltered (grass tree cavities, soil) and open‐air microsites, with the former being cooler during the day and warmer and more humid during the night. Furthermore, our results suggest that canopy cover tends to decrease, and understorey cover tends to increase, the temperature of microsites. Distance to the edge was not significantly related to temperature for any microsite, suggesting that the edge effect did not extend beyond 10 m from the edge. Overall, grass trees influenced microclimatic conditions by forming a dense understorey and providing cavities that are relatively insulated. The capacity of grass tree cavities to buffer external conditions increased linearly with ambient temperatures, by 0.46°C per degree increase in maximum and 0.25°C per degree decrease in minimum temperatures, potentially offsetting climate warming and enabling persistence of fauna within their thermal limits. These climate moderation properties will make grass trees increasingly important refuges as extreme weather events become more common under anthropogenic climate change.
The Impact of Foundational AI on International Trade, Services and Supply Chains in Asia
Authors: Meltzer Joshua P. 
Published: November 2023

ABSTRACTFoundational artificial intelligence (AI) is a general purpose technology that will affect economic activity across industries, with potentially significant impacts on jobs and international trade. This could include automation of routine and nonroutine white‐collar jobs, which reduces international trade where these jobs are on‐shored. However, where AI compliments existing jobs and leads to higher productivity, this could open up new opportunities for international trade in services. How foundational AI affects international trade will also depend on how it is regulated. Governments are moving to regulate AI, which could become a barrier to international trade. Geopolitics could also undermine opportunities for AI to deepen globalization and trade in AI as the USA and China restrict trade in the technology needed to build and run foundational AI systems. Regulating the impact of AI on international trade is an increasing focus in free trade agreements (FTAs) and digital economy agreements (DEAs). The World Trade Organization (WTO) Joint Statement Initiative (JSI) e‐commerce negotiations could also support trade in AI. Yet, there is much more that trade policy could do to minimize barriers to trade in AI.
Combination treatment with monoclonal antibodies: Dupilumab and ustekinumab for the treatment of severe atopic dermatitis and Crohn disease
Authors: Alegre‐Bailo Alberto , Sánchez‐Gilo Araceli , Gonzalo González Inés , Vicente Martín Francisco Javier 
Published: November 2023

AbstractEvidence of effectiveness and safety in combined therapies is scarce and based on case reports and small case series. We report a case of dual biologic therapy with ustekinumab and dupilumab in a patient with severe Crohn disease and atopic dermatitis. There was no interference between these drugs after a 7‐month follow‐up.
Association of maternal SARS‐CoV‐2 infection at the time of admission for delivery with labor process and outcomes of vaginal birth: A cohort study
Authors: Chen An , Acharya Ganesh , Hu Min , Gao Xin , Cheng Guizhi , Jiang Lai , Ni Qianqian 
Published: November 2023

AbstractIntroductionThis study aimed to investigate the impact of maternal SARS‐CoV‐2 infection at the time of admission for delivery on labor process and outcomes of vaginal birth.Material and methodsA cohort study was carried out at the Obstetrics Department of Anhui Provincial Hospital, China, where universal reverse transcriptase polymerase chain reaction (RT‐PCR) testing for SARS‐CoV‐2 infection was introduced for all women admitted for labor and delivery from December 1–31, 2022. Women were divided into positive and negative groups based on the test result. All women having a singleton vaginal birth were included in final analysis. The effect of SARS‐CoV‐2 positivity on labor process and outcomes of vaginal birth was estimated by regression analyses.ResultsAmong a total of 360 women included, 87 had a positive SARS‐CoV‐2 test and 273 a negative test. Women in the positive group had an increased likelihood of having longer labor (median 9.3 vs 8.3 hours; sB [log‐transformed] 0.19; 95% confidence interval [CI] 0.09–0.28), episiotomy (39.1% vs 23.8%; adjusted odds ratio [aOR] 2.31; 95% CI 1.27–4.21), grade III meconium‐stained amniotic fluid (19.5% vs 7.0%; aOR 2.52; 95% CI 1.15–5.54) and postpartum hospital stay exceeding 37 hours (58.6% vs 46.5%; aOR 1.71; 95% CI 1.00–2.91). They had reduced rates exclusive breastfeeding (26.7% vs 39%; aOR 0.21; 95% CI 0.09–0.46) as well as mixed feeding (46.5% vs 52.2%; aOR 0.28; 95% CI 0.13–0.60) at 1 week postpartum. No significant differences were observed in other aspects of labor process and birth outcomes, including the uptake of labor analgesia, postpartum hemorrhage (>500 mL) or neonatal outcomes.ConclusionsA positive maternal SARS‐CoV‐2 test in labor among women having vaginal birth was associated with a slightly longer duration of labor, increased likelihood of episiotomy, increased incidence of grade III meconium‐stained amniotic fluid, a longer postpartum hospital stay and a lower rate of breastfeeding 1 week postpartum. However, it did not have an adverse impact on other birth outcomes.
Maternal ethnicity and gestational age at birth predict hypoglycaemia among neonates of mothers with gestational diabetes
Authors: Oladimeji Oluwatoyin Ibukun , Harding Jane , Gamble Greg , Crowther Caroline , Lin Luling 
Published: November 2023

AbstractAimHypoglycaemia is common in neonates born to mothers with gestational diabetes mellitus (GDM). We aimed to determine predictors of hypoglycaemia among neonates of women with GDM and association with short‐term outcomes.MethodsWe conducted a secondary cohort analysis of data from a multi‐centre randomised trial (the TARGET trial) conducted across ten maternity hospitals in New Zealand between May 2015 and November 2017. Data were analysed using univariate analysis and multivariable forward stepwise logistic regression.ResultsAmong 1085 neonates, those born to Asian mothers had reduced odds of hypoglycaemia (OR [95% CI]: 0.54 [0.38, 0.75], p = 0.001), as did those born at higher gestational ages (0.76 [0.68, 0.85], p < 0.001). Neonates born to Pacific mothers had increased odds of hypoglycaemia (OR [95% CI]: 1.57 [1.04, 2.39], p = 0.034). Neonates who experienced hypoglycaemia were more likely to experience neonatal intensive care unit admission (8.3% vs. 2.1%; p ≤ 0.001), hyperbilirubinaemia (8.6% vs. 3.3%; p ≤ 0.001) and receive respiratory support (11.4% vs. 4.8%; p ≤ 0.001) and less likely to be breastfed at discharge (92.4% vs. 96.2%; p = 0.009).ConclusionAmong neonates of women with GDM, maternal ethnicity and gestation at birth are independent predictors of hypoglycaemia, and hypoglycaemia is associated with short‐term comorbidities. Additional surveillance may be appropriate for neonates in these high‐risk groups.
COVID‐19 and mental health in the UK: Depression, anxiety and insomnia and their associations with persistent physical symptoms and risk and vulnerability factors
Authors: Yu Lin , McCracken Lance M. 
Published: November 2023

AbstractObjectivesMental health problems and persistent COVID‐19 symptoms were prevalent in the context of COVID‐19. However, despite the long‐observed association between physical symptoms and mental health problems, such association has not been adequately examined in the context of COVID‐19. Our understanding of wider patterns of risk and vulnerability factors for mental health also remains limited. This study investigated the associations between general mental health, and persistent physical symptoms, and additional risk and vulnerability factors in the context of COVID‐19.MethodsTwo hundred fourteen adults, living in the UK, recruited via social media, completed the online survey and were included in the analyses. Correlation and regression analyses were conducted to examine the associations of persistent physical symptoms and risk and vulnerability factors with measures of general mental health including depressive symptoms, anxiety and insomnia.Results78.5% of the participants reported between 1 and 26 persistent symptoms, and about 28%–92% of them associated these symptoms with COVID‐19 infection. Persistent physical symptoms were uniquely associated with all measures of mental health, β = .19–.32. Mental health history and worries were the most prominent risk factors, |β| = .12–.43.ConclusionsPeople who experience more persistent physical symptoms post‐COVID‐19 have poorer mental health. It may be important to consider and discuss the recovery from COVID‐19 beyond a negative COVID‐19 test. Multidisciplinary interventions that address the complex impact of COVID‐19 for people with long COVID are needed.
The interplay between siliciclastic and carbonate depositional systems: Maastrichtian to Danian basin‐floor sediments of the mid‐Norwegian Møre Basin
Authors: Kjøll Hans Jørgen , Midtkandal Ivar , Planke Sverre , Millett John , Manton Ben , Anderskouv Kresten 
Published: November 2023

AbstractSource‐to‐sink sedimentary systems associated with volcanic rifted margins serve as important archives for basin development by recording lithospheric changes affecting the depositional systems. Distinguishing between sediment transport processes and their sediment source(s) can guide the interpretation of a basin's history, and thereby inform regional paleogeographic reconstructions. In this contribution, we integrate and utilize wireline geophysical logs, detailed petrographic observations from side‐wall cores, and seismic analysis to describe and decipher a Maastrichtian to Danian‐aged basin‐floor depositional system in the deep outer Møre Basin, mid‐Norwegian margin. Well 6302/6‐1 (Tulipan) is a spatially isolated borehole drilled in 2001 that penetrates Maastrichtian and younger strata. A succession of hitherto undescribed carbonates and sandstones in the outer Møre Basin was discovered. It is investigated for sediment transport, provenance, and depositional processes on the basin floor surrounded by structural highs and ridges. The strata from the lower parts form a basin‐floor apron consisting of redeposited carbonate sourced from a westerly sub‐aerial high. The apron transitions vertically from mixed siliciclastic and carbonate into a purely siliciclastic fan with intercalated sandstone and mudstone, providing a rare high‐resolution record of how depositional environments experience a complete shift in dominant processes. The development coincides with similar latest Cretaceous‐earliest Palaeocene sequences recorded south of this region (e.g., well 219/20‐1) and may have been influenced by regional uplift associated with the onset of magmatism in the Northeast Atlantic. This study improves our understanding of a late, pre‐breakup source‐to‐sink sedimentary system developed near the breakup axis of an infant ocean, and documents what is possibly the northernmost chalk deposit in the Chalk Group.
Discovery a series of novel inhibitors of human dihydroorotate dehydrogenase: Biological activity evaluation and molecular docking
Authors: Ren Xiaoli , Liu Xiaoyong , Hua Miao , Dai Yan , Ren Xiaoping , Sui Chaoya , Li Xiangbi , Jiang Zhiyong , Tian Min , Yang Bing 
Published: November 2023

AbstractHuman dihydroorotate dehydrogenase (hDHODH) is a key enzyme that catalyzes the de novo synthesis of pyrimidine. In recent years, various studies have shown that inhibiting this enzyme can treat autoimmune diseases such as rheumatoid arthritis (RA) and cancer. This study designed and synthesized a series of novel thiazolidone hDHODH inhibitors. Through biological activity evaluation, Compound 14 was found to have high inhibitory activity, with an IC50 value reaching nanomolar level. Preliminary structure–activity relationship studies found that the carboxyl group in R1 and the naphthalene in R2 are key factors in improving activity. Through molecular docking, the binding mode between inhibitors and proteins was elucidated. This study provides an important reference for further optimizing hDHODH inhibitors.
Parents' expected barriers to psychosocial care for children with complex problems
Authors: Pannebakker Noortje M. , Reijneveld Sijmen A. , Numans Mattijs E. , Kocken Paul L. 
Published: November 2023

AbstractBackground and objectiveEven though children with complex problems frequently need psychosocial care, two thirds does not receive treatment. Various barriers, particularly expectations of barriers, can hinder effective access of care. Our aim was to assess the practical barriers expected by parents, and the child, family and need factors associated with these expected barriers.MethodsWe sent web‐based questionnaires to parents of a random sample of children known to have or be at risk of having complex problems (response = 77%). We used backward regression analyses to examine which factors were associated with expected barriers for children using psychosocial care, or no care at all.ResultsSeventy‐three percent of all parents expected practical barriers. Parents of children using psychosocial care expected more barriers than when using no care at all. For children who used no care, parents of girls expected more barriers (regression coefficient 0.54; 95%—confidence interval 0.16, 0.92) as did families having less social support (−0.30; −0.50, −0.11). When children used psychosocial care, parents expected more barriers when their child was of school‐age (0.38; 0.01, 0.75), of non‐western origin (vs. native) (0.52; 0.17, 0.88), when parents were older (i.e., 36+ years) (−0.77; −1.12, −0.42), experienced more adverse life events (0.29; 0.13, 0.45) or had less social support (−0.17; −0.34, 0.00).ConclusionEven when their child is already receiving treatment, parents continue to expect practical barriers to psychosocial care. Psychosocial care services and their gatekeepers should address these concerns. Access to psychosocial care can be improved by removing practical barriers, especially if children already receive psychosocial care, or when parents have a limited network or belong to an ethnic minority.