bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds
Authors: Jagielska Anna , Radzwill Kristin , Espinosa-Hoyos Daniela , Yang Mingyu , Kowsari Kavin , Farley Jonathan E. , Giera Stefanie , Byrne Ann , Sheng Guoqing , Fang Nicholas X. , Dodge James C. , Pedraza Carlos E. , Van Vliet Krystyn J. 
Published: November 2023

AbstractMultiple sclerosis (MS), a chronic neurodegenerative disease driven by damage to the protective myelin sheath, is currently incurable. Today, all clinically available treatments modulate the immune-mediated symptoms of the disease but they fail to stop neurodegeneration in many patients. Remyelination, the regenerative process of myelin repair by oligodendrocytes, which is considered a necessary step to protect demyelinated axons and stop neuronal death, is impaired in MS patients. One of the major obstacles to finding effective remyelinating drugs is the lack of biomimetic drug screening platforms that enable quantification of compounds’ potential to stimulate 3D myelination in the physiologically relevant axon-like environment. To address this need, we built a unique myelination drug discovery platform, by expanding our previously developed technology, artificial axons (AAs), which enables 3D-printing of synthetic axon mimics with the geometry and mechanical properties closely resembling those of biological axons. This platform allows for high-throughput phenotypic myelination assay based on quantification of 3D wrapping of myelin membrane around axons in response to compounds. Here, we demonstrate quantification of 3D myelin wrapping by rat oligodendrocytes around the axon mimics in response to a small library of known pro-myelinating compounds. This assay shows pro-myelinating activity for all tested compounds consistent with the published in vitro and in vivo data, demonstrating predictive power of AA platform. We find that stimulation of myelin wrapping by these compounds is dose-dependent, providing a facile means to quantify the compounds’ potency and efficacy in promoting myelin wrapping. Further, the ranking of relative efficacy among these compounds differs in this 3D axon-like environment as compared to a traditional oligodendrocyte 2D differentiation assay quantifying area of deposited myelin membrane. Together, we demonstrate that the artificial axons platform and associated phenotypic myelin wrapping assay afford direct evaluation of myelin wrapping by oligodendrocytes in response to soluble compounds in an axon-like environment, providing a predictive tool for the discovery of remyelinating therapies.
Association of daily health behavior and activity of daily living in older adults in China
Authors: Wang Ling-Ying , Feng Mei , Hu Xiu-Ying , Tang Meng-Lin 
Published: November 2023

AbstractThis study aims to describe the activity of daily living (ADL) situation and determine the relationship between health behavior and ADL among older adults in China. A cross-sectional, observational study was conducted in one urban community and one rural community in Chengdu (a city located in Southwest China), China, from October 2022 to March 2023. A total of 706 older adults were included in this study. The associations between health behaviour and ADL were assessed by logistic regression model. Of the 706 older adults, 169 (23.9%) were disabled in ADL. According to the logistic regression analysis, age (60–69 years old: OR = 0.015, 95% CI 0.007 to 0.035, P < 0.001; 70–79 years old: OR = 0.116, 95% CI 0.060 to 0.227, P < 0.001), resident(OR = 0.568, 95% CI 0.330 to 0.976, P = 0.041), chronic disease (0 type: OR = 0.023, 95% CI 0.001 to 0.379, P = 0.008; 1–4 types: OR = 0.357, 95% CI 0.219 to 0.582, P < 0.001), no exercise (OR = 4.562, 95% CI 2.263 to 8.026, P < 0.001), and physical examination (OR = 2.217, 95% CI 1.294 to 3.496, P = 0.003) were significantly associated with ADL among older adults in Southwest China. This study showed that older adults had a higher ADL disability ratio. Age, resident, chronic disease, exercise and physical examination were associated with ADL among older adults. The study indicates that medium/high exercise maybe a protective factor for older adults, and nursing staff can encourage older adults to exercise when carrying out primary prevention measures. The government and public health institutions should give special attention to older adults and help them to acquire the habit of having an annual physical examination.
The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation
Authors: Ran Xiao-min , Xiao Hui , Tang Yan-xiang , Jin Xia , Tang Xing , Zhang Juan , Li Hui , Li Yu-kun , Tang Zhen-zi 
Published: November 2023

AbstractGynecological cancers are a leading cause of mortality for women, including ovarian cancer (OC), cervical squamous cell carcinoma (CESC), and uterine corpus endometrial carcinoma (UCEC). Nevertheless, these gynecological cancer types have not elucidated the role of cuproptosis and the correlated tumor microenvironment (TME) infiltration features. CRGs had important potential molecular functions and prognostic significance in gynecological cancers, especially in UCEC. Hub CRG, FDX1, was correlated with the CD8+ T cell immune infiltration in UCEC and CESC. FDX1 OE could significantly repress the proliferation ability in UCEC cells by MTT, EdU, and clone formation. High levels of FDX1 could repress ATP and lactic acid but enhance ROS and glucose levels by metabolism assay. The xenograft tumor model indicated that FDX1 OE significantly inhibited the growth of UCEC and attenuated the PCNA, HK2, PKM2, and Ki-67 expression. These CRGs are significant roles that could be potential markers and treatment targets to optimize the TME immune cell infiltration features for gynecological cancer types. FDX1 is a hub CRGs in UCEC to promote immune infiltration and attenuate proliferation and metabolism.
Polarization-insensitive Archimedes’-spiral-shaped ultrathin metamaterial absorbers for microwave sensing application
Authors: Lateef Omar S. , Al-Badri Mohammed , Al-badri Khalid Saeed Lateef , Mohammed Sarah Adnan 
Published: November 2023

AbstractThis work has developed and simulated a planar complementary Archimedes-based metamaterial absorber with the goal of its application in refractive index sensing. Unlike designs that employ multiple layers or numerous resonators within a single unit cell, our proposed absorber adopts a more streamlined approach. It consists of three layers, with an FR4 dielectric substrate sandwiched between two copper layers. It's important to note that the absorption characteristics of this design are polarization-dependent. This polarization dependence arises from the asymmetrical resonance behavior observed in both the x and y directions. The absorber exhibits impressive absorption rates at various resonance frequencies, namely 98.5% at f1 = 8.49 GHz, 77.1% at f2 = 8.88 GHz, 88.7% at f3 = 9.3 GHz, 98.2% at f4 = 9.87 GHz, 99.7% at f5 = 10.65 GHz, 83.4% at f6 = 11.58 GHz, and 99.9% at f7 = 12.24 GHz. Furthermore, the article explored the refractive index sensing capabilities of this structure by introducing a 1 mm analyte layer on top of the patch structure. Through refractive index sensing analysis, we've determined that this absorber-based sensor yields an impressive high-quality factor value of 84.5, highlighting its remarkable sensitivity and precision. A more profound comprehension of the physical mechanisms in action has been attained by examining the distribution of surface currents. Furthermore, the behavior of the absorber has been investigated under varying polarization and incident angle conditions, ranging from zero degrees to sixty degrees. The thorough characterization establishes this absorber as a promising choice for microwave sensing applications.
Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study
Authors: Du Rui , Tang Xiaoyan , Jiang Meihua , Qian Shengli , Yang Li , Tong Xiaoling , Huang Wei 
Published: November 2023

AbstractAlpha klotho (α-Klotho) is an anti-aging molecule associated with aging and several diseases. Previous studies have reported inconsistent levels of α-Klotho in smokers. This study aimed to demonstrate serum α-Klotho levels in smokers among the US population. This cross-sectional study recruited 11,559 participants (aged 40–79 years; 48.2% males). All data were collected from the 2007–2016 National Health and Nutrition Examination Survey. The study comprised adults with reliable Klotho and smoking questionnaire results. The relationship between smoking and serum α-klotho levels was assessed using multivariate linear regression models after adjusting for potential confounders. We also performed a stratified analysis of clinically important variables. The mean serum α-klotho level among the 11,559 participants was 843.85 pg/mL. After full adjustment, habitual smoking was significantly associated with decreased serum levels of α-klotho level (β = − 34.89; 95% CI − 54.97, − 14.81; P = 0.0013) in the total study population. Furthermore, the stratified analysis indicated that the association was insignificant in the 60–79 age group. Quitting smoking was not significantly associated with serum levels of α-klotho as expected (P = 0.1148) in the total study population. However, stratified analyses showed a significant inversed association in the male, those with chronic kidney disease, or those with cancer who quit smoking (all P < 0.05). Cigarette smoking was inversely associated with serum α-Klotho levels among US adults.
Detection of factors related to treatment reduction in docetaxel and ramucirumab for non-small cell lung cancer treatment
Authors: Saito Yoshitaka , Tamaki Shinya , Hirate Daisuke , Takada Shinya , Takahashi Kenta , Takekuma Yoh , Sakakibara-Konishi Jun , Shimizu Yasushi , Kinoshita Ichiro , Sugawara Mitsuru 
Published: November 2023

AbstractTreatment using docetaxel (DOC) and ramucirumab (RAM) is an effective regimen in second or later line advanced non-small cell lung carcinoma (NSCLC) treatment. However, it induces severe adverse effects, resulting in treatment reduction such as dose reduction and/or discontinuation. This study aimed to reveal the factor(s) associated with treatment reduction in DOC + RAM. We retrospectively evaluated patients with advanced NSCLC (n = 155). Treatment reduction of the second course due to severe adverse effects was conducted in 25.8% of the participants, and relative dose intensity at the second course was 95.7 ± 8.4% for DOC and 91.9 ± 24.8% for RAM. Multivariate logistic regression analyses identified that baseline anemia and prophylactic granulocyte colony-stimulating factor (G-CSF) administration are preventive factors for the reduction (adjusted odds ratio, 0.29; 95% confidence interval, 0.12–0.66; P = 0.004 for baseline anemia, 0.18; 0.08–0.42; P < 0.0001 for prophylactic G-CSF administration). The primary cause of the reduction was febrile neutropenia, and the same factors were identified. Our study revealed that patients with baseline anemia and prophylactic G-CSF administration have less risk for treatment reduction in DOC + RAM for NSCLC treatment.
Optimization and antifungal efficacy against brown rot fungi of combined Salvia rosmarinus and Cedrus atlantica essential oils encapsulated in Gum Arabic
Authors: Annemer Saoussan , Ez-zoubi Amine , Ez zoubi Yassine , Satrani Badr , Stambouli Hamid , Assouguem Amine , Ullah Riaz , Bouayoun Taoufik , Fettoukh Nezha , Farah Abdellah 
Published: November 2023

AbstractThe stability, sensitivity, and volatility of essential oils are some of their most serious limitations, and nanoencapsulation has been considered one of the most effective techniques for solving these problems. This research aimed to investigate the incorporation of Salvia rosmarinus Speen and Cedrus atlantica Manetti (MEO) essential oil mixture in Gum Arabic (GA) and to evaluate nanoencapsulation’s ability to promote antifungal activity against two brown rot fungi responsible for wood decay Gloeophyllum trabeum and Poria placenta. The optimization of encapsulation efficiency was performed using response surface methodology (RSM) with two parameters: solid-to-solid (MEO/GA ratio) and solid-to-liquid (MEO/ethanol). The recovered powder characterization was followed by various techniques using a scanning electron microscope (SEM), X-ray diffractometry (XRD), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), and thermo-gravimetric analysis (TGA). The optimal nanoencapsulating conditions obtained from RSM were ratios of MEO/GA of 1:10 (w/w) and MEO/ethanol of 10% (v/v), which provided the greatest encapsulation efficiency (87%). The results of SEM, XRD, DLS, FTIR, and TGA showed that the encapsulation of MEO using GA modified particle form and molecular structure and increased thermal stability. An antifungal activity assay indicated that an effective concentration of MEO had an inhibitory effect on brown rot fungi. It had 50% of the maximal effect (EC50) value of 5.15 ± 0.88 µg/mL and 12.63 ± 0.65 µg/mL for G. trabeum and P. placenta, respectively. Therefore, this product has a great potential as a natural wood preservative for sustainable construction and green building.
Sociodemographic characteristics of healthy volunteers along with their experience, attitude and concerns of clinical trials in Wuhan, China
Authors: Yu Hengyi , Fang Yinian , Qi Xinxin , Wang Kaifu , Lei Yongfang , Zhang Donglin , Chen Qian , Liu Dong , Ren Xiuhua 
Published: November 2023

AbstractChina has became the world’s second largest pharmaceutical market, and the number of her registered clinical trials exceeded 3000 in 2021. Although thousands of healthy volunteers are participating in a large number of clinical trials in this country, there is no report about the characteristics, recognition, attitude of Chinese healthy volunteers and their concerns of clinical trials. A questionnaire survey was designed and given to 324 healthy volunteers participating in clinical trials in Wuhan, China. Four important findings emerged from our data. First, young, single and less educated men constituted the majority of Chinese healthy volunteers. Second, differences between the male and female healthy volunteers were observed. Female healthy volunteers are supposed to face more challenges and pressure in life, be more cautious about the clinical trials and more concerned about their health and feelings than the male. Third, no sociodemographic characteristic was associated with poorly understanding of the protocol research content, which was subjectively evaluated. Fourth, more support from society/family and more positive media reports about the participation of healthy volunteers in clinical trials are badly needed. These findings would help us to get a better understanding of Chinese healthy volunteers as a group for protecting them and promoting drug development.
Three-Year Program Evaluation of a University–Public School Collaborative Partnership
Authors: Koutsoftas Anthony D. , Maffucci Dawn , Dayalu Vikram N. 
Published: November 2023

Purpose:
This clinical focus article reports on an innovative program that provides classroom-based speech and language services to school children receiving speech-language therapy while addressing the need for clinical placements for graduate students in speech-language pathology. This program evaluation report centers around the logic model used to develop and implement the program.

Method:
The program was implemented in partnership between a university program in speech-language pathology and a nearby school district. The program took place in two different schools within the district, each with one state licensed and American Speech-Language-Hearing Association–certified speech-language pathologist (SLP) who supervised two or three graduate student interns per year of the project for a total of 17 graduate students over 3 years. Data sources for this program evaluation included child-level data collected by graduate student interns, teacher satisfaction surveys, and semistructured interviews.

Results:
Program stakeholders including graduate student interns, speech-language pathology supervisors, and the school district administrator provided converging positive feedback about the program implementation. This was corroborated by favorable ratings from teachers who collaborated with graduate student interns and an increase in the number of classroom-based intervention hours for school children receiving speech-language services.

Conclusions:
The short-, medium-, and long-term outcomes of the program's logic model were achieved in part or fully as supported by data sources used for program evaluation procedures. Clinical implications are provided about the need for innovation in school-based services with a focus on collaborative classroom-based intervention.
Robust model reference tracking control for high‐order descriptor linear systems subject to parameter uncertainties
Authors: Gao Ya‐Jun , Duan Guang‐Ren 
Published: November 2023

AbstractThis paper investigates the robust model reference tracking control problem for high‐order descriptor linear systems (HODLS) subject to norm‐bounded parameter uncertainties. The problem is divided into two subproblems: a robust proportional plus derivative state feedback stabilization (RPPDSFS) problem and a robust feed‐forward compensation (RFFC) problem. In the presence of uncertainties, by using the controller consisting of RPPDSFS part and RFFC part, all the signals of the closed‐loop system are bounded. The latter is equivalent to seeking three coefficient matrices such that a series of linear matrix equations are satisfied, and simultaneously the effect caused by uncertainties is minimized. Based on the right coprime factorization, the RFFC problem is further converted into a minimization problem with a quadratic performance index and some linear constraints. Thereafter, a linear matrix equation that determines the optimal solution is achieved. The restrictive condition that the coefficient matrix of the augmented reference system is non‐defective is relaxed, which reduces the conservativeness. A numerical example and the application of a three‐axis dynamic flight motion simulator manifest the effectiveness and the practicability of the proposed algorithm.
Bio‐fabrication of silver nanoparticles using an aqueous extract of Quercus baloot: Preparation, characterization and in vitro antimicrobial evaluation
Authors: Rabbi Fazle , Nisar Amna , Nawaz Noor Ul Ain , AlMasoud Najla , Alomar Taghrid S. , Rauf Abdur 
Published: November 2023

Abstract
In the current study, a novel method was used to synthesize silver nanoparticles (AgNPs) by utilizing Quercus baloot aqueous extract as a reducing agent. The biosynthesized AgNPs were then subjected to various physicochemical characterizations to assess their effectiveness against microbial familiarity. The characterization techniques included ultraviolet‐visible spectro‐photometry (UV‐Vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X‐ray diffractometer (XRD), and Fourier‐transform infrared spectroscopy (FTIR). The UV‐Vis analysis revealed a distinctive spectral peak at 420 nm, indicating the presence of silver nanoparticles. SEM imaging displayed the nanoparticle size range of about 100 nm at a magnification of 30,000x, while TEM demonstrated that the nanoparticles had a spherical morphology with a size of approximately 100 nm. Moreover, the crystalline structure of the silver nanoparticles was confirmed by XRD analysis, further validating their successful synthesis. Additionally, FTIR analysis provided evidence of the presence of phytochemicals involved in synthesizing the AgNPs. the biosynthesized silver nanoparticles (AgNPs) were evaluated for antibacterial and antifungal activities. The AgNPs displayed substantial efficacy against common bacterial strains, including Staphylococcus aureus (71%), Escherichia coli (59%), and Klebsiella pneumoniae (64%). Furthermore, they demonstrated significant antifungal activity against plant pathogenic fungi, namely Aspergillus niger (65%), Aspergillus flavus (70%) and Fusarium oxysporum (61%).
Radar‐based human activity recognition using denoising techniques to enhance classification accuracy
Authors: Yu Ran , Du Yaxin , Li Jipeng , Napolitano Antonio , Le Kernec Julien 
Published: November 2023

AbstractRadar‐based human activity recognition is considered as a competitive solution for the elderly care health monitoring problem, compared to alternative techniques such as cameras and wearable devices. However, raw radar signals are often contaminated with noise, clutter, and other artifacts that significantly impact recognition performance, which highlights the importance of prepossessing techniques that enhance radar data quality and improve classification model accuracy. In this study, two different human activity classification models incorporated with pre‐processing techniques have been proposed. The authors introduce wavelet denoising methods into a cyclostationarity‐based classification model, resulting in a substantial improvement in classification accuracy. To address the limitations of conventional pre‐processing techniques, a deep neural network model called Double Phase Cascaded Denoising and Classification Network (DPDCNet) is proposed, which performs end‐to‐end signal‐level classification and achieves state‐of‐the‐art accuracy. The proposed models significantly reduce false detections and would enable robust activity monitoring for older individuals with radar signals, thereby bringing the system closer to a practical implementation for deployment.
Un shot de synTac pour activer la réponse cytotoxique des lymphocytes T CD8+ spécifiques du VIH
Authors: Flescq Charlène , Gachon Alexis , Saez Cirion Asier 
Published: November 2023

Dans le cadre de leur module d’analyse scientifique, des étudiants des Master 2 « Immunologie Translationnelle et Biothérapies » (ITB) et « Immunologie Intégrative et Systémique » (I2S) (mention biologie moléculaire et cellulaire, parcours immunologie, Sorbonne université) se sont penchés sur la littérature et ont pris la plume pour partager avec les lecteurs de m/s quelques-uns des faits marquants de l’actualité en immunologie. Voici une sélection de ces nouvelles, illustrant certaines des stratégies actuellement développées pour optimiser les immunothérapies.