bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization control of guide bar array deformation in flexible‐oriented 3D woven process
Authors: Liu Yang , Shan Zhongde , Liu Feng , Sun Zheng 
Published: January 2024

AbstractThe flexible‐oriented 3D woven process (FO3DWP) enables the production of high‐performance 3D composite preforms. However, the deformation of the Guide Bar Array (GBA) during the weaving process poses a major challenge and hinders the further advancement of FO3DWP. This study aimed to address this challenge by developing an optimization control method for automatic GBA correction during the manufacturing of 3D orthogonal preforms. The deformation state was predicted using a theoretical model and a control path was designed to reverse the GBA deformation. The height and fiber tension of the control paths were calculated using the particle swarm optimization (PSO) algorithm. A series of 3D woven experiments were conducted to evaluate the effectiveness of the proposed method. The results showed good agreement between the experimental and theoretical deformation eigenvalues (with a difference of less than 15%), and the control path significantly reduced the deformation eigenvalues. This method holds great potential for aerospace applications as it enables high‐quality production through automatic GBA correction by the weaving mechanism.Highlights
A control path was designed to automatically correct the deformed GBA.
The height and the fiber tension of the control path were calculated using the PSO algorithm.
The experimental eigenvalues in the y‐direction were significantly reduced by the optimization control method.
Effect of particle size distribution on the cryogenic mechanical properties of triple‐base propellants
Authors: Li Qiang , Huang Juan , Wang Sheng , Gao Heng , Zhang Jianwei , Jin Guorui , Chen Ling , He Weidong , Wang Binbin 
Published: January 2024

AbstractFillers play a decisive role in the mechanical properties of polymer composites. In this paper, different particle sizes of nitroguanidine were obtained to regulate the internal filler structure of triple‐base propellants (TBP) to improve their mechanical response in different environments. A series of morphological and structural characterizations on nitroguanidine (NQ) particles were conducted using techniques. The results indicated that the obtained NQ particles maintained a high level of crystalline quality while preserving their molecular integrity. The mechanical properties of TBP were systematically evaluated under various loading conditions, including cryogenic tensile, compressive, and impact loads, as well as dynamic thermomechanical effects. Additionally, three‐point bending simulations were employed to elucidate the mechanical responses and damage mechanisms. Under axial tensile and compressive loads, reducing the particle size of NQ significantly enhanced the tensile and compressive strength. The maximum tensile strength and compressive strength can reach 344.62 MPa and 104.79 MPa. Moreover, the compressive failure mode transitioned from cracking to axial shrinkage. Conversely, when subjected to radial bending loads, TBP exhibited contrasting behavior, including a decrease in the glass transition temperature from 84.73°C to 76.93°C and a non‐monotonic trend in impact strength (initially increasing from 4.96 to 8.85 kJ/m2 and then decreasing to 2.27 kJ/m2). This study provides valuable insights into the mechanical performance of TBP, supporting the development of high‐energy, high‐strength TBP formulations.Highlights
SEM analysis confirms the pronounced orientation effect of rod‐like NQ.
The orientation and particle size of NQ decide TBP's radial impact resistance.
Submicron NQ enhances the compression resistance property of TBP.
Submicron NQ brings about a shift in the microscopic damage morphology of TBP.
Effect of pineapple leaf and ramie fiber length and weight percentage on the hybrid polymer composites dry sliding wear and air jet erosion studies
Authors: Arivendan Ajithram , Chen Xiaoqi , Zhang Yuan‐Fang , Gao Wenhua , Thangiah Winowlin Jappes Jebas 
Published: January 2024

AbstractIn this work, pineapple leaf fiber (PALF) and ramie hybrid fiber‐reinforced epoxy composite samples were evaluated for their hardness strength and resistance to dry slide wear and air jet erosion. Primary reinforcement using the hybrid material was chosen from different lengths (10, 15, 20, and 25 mm) and weight percentages (10%, 20%, 30%, 40%, and 50%). The hardness strength of the hybrid composite varied from 74 to 97 Shore D hardness strength. A dry sliding wear test was conducted with the key parameters of load (20, 30, and 40 N), time (20, 10, 7 min), and speed (160, 320, and 479 rpm). By using the data analyzing software, Taguchi optimization method, the key contribution parameters were identified. In the air jet erosion experiment, impact angle (45°, 60°, and 90°), erodent velocity (28, 41, and 72 m/s), and discharge rate (1, 2.5, and 3.3 g/min) parameters were used. Fiber and matrix materials agglomeration effect and bonding behavior were identified by using the scanning electron microscope (SEM) images. The 20 mm length with 30% of the PALF and ramie hybrid fiber‐reinforced composite sample achieved high hardness strength (97 shore D) and created a high resistance toward wear and erosion studies.Highlights
Natural plant pineapple leaf and ramie fibers are mixed with an epoxy matrix.
Used Taguchi analysis to determine the means and signal‐to‐noise ratios
Different weight percentages of the PALF and ramie hybrid composites
Dry sliding wear and air jet erosion studies are conducted.
Individual parameter contributions were identified.
BMI increase during early childhood in boys with cystic fibrosis and early adrenarche
Authors: Tamer Gizem , Arets Hubertus Gerardus Maria , van der Ent Cornelis Kors , van Santen Hanneke Margo , van der Kamp Hetty Jacoba 
Published: January 2024

AbstractBackgroundIncrease in body mass index (BMI) in early childhood (1−6 years) was found to be a contributing factor for impaired final height in boys with Cystic Fibrosis (CF). Early adrenarche (before age 9 years in boys) may contribute to an impaired final height by triggering an early acceleration of bone age resulting in a compromised growth spurt during puberty. We aimed to analyze the timing of adrenarche in boys with CF and to associate BMI increase in early childhood to timing of adrenarche.MethodsBoys with CF, aged 8−9 years, visiting the CF expertize center Utrecht were included. Since 2018, anthropomorphic, pubertal and endocrine data were collected. Early adrenarche in boys was defined as a dehydroepiandrosterone sulfate (DHEAS) ≥ 1 µmol/L before the age of 9 years.ResultsThirteen boys (mean age 8.55 ± 0.27 years) were enrolled. The median (IQR) DHEAS‐level was 1.3 µmol/L (0.71−2.40). Eight boys (61.5%) had an early rise in DHEAS‐levels ≥ 1 µmol/L. Mean increase in BMI Z‐score between 1 and 6 years of age (ΔBMI1−6) was −0.07 ± 0.86. A significant correlation was found between ΔBMI1−6 and DHEAS‐levels at the age of 8−9 years (r = 0.624, p = 0.040). In five boys with early rise in DHEAS, accelerated bone age was found (average 1.55 ± 0.96 years).ConclusionIn this small cohort, 61.5% of boys with CF between 8 and 9 years had an early rise of DHEAS, which was correlated to ΔBMI1−6 between 1 and 6 years. Early adrenarche may be caused by ΔBMI1−6.
Successful dabrafenib and trametinib combination therapy in a patient with recurrent BRAFV600E‐mutant non‐small‐cell lung cancer and coexisting radiation pneumonitis
Authors: Nakamura Eriko , Ota Masahide , Matsuda Ryosuke , Takeda Maiko , Fujii Tomomi , Yamamoto Yoshifumi , Hontsu Shigeto , Yamauchi Motoo , Yoshikawa Masanori , Muro Shigeo 
Published: January 2024

AbstractThere have been several reports of drug‐induced lung injury caused by molecular‐targeted agents. Additionally, medical history of interstitial lung disease and chest irradiation are established risk factors for the development and progression of drug‐induced lung injury. Moreover, the presence of fibrosis on chest computed tomography before treatment is a predictive factor for the appearance of pneumonia induced by anticancer drugs. Accordingly, patients with a history of interstitial lung disease or pneumonitis were excluded from clinical trials of dabrafenib and trametinib combination therapy for patients with previously treated BRAF V600E‐mutant metastatic non‐small‐cell lung cancer. This article presents a case of successful dabrafenib and trametinib combination therapy in a patient with BRAF V600E‐mutant non‐small‐cell lung cancer who had a history of radiation pneumonitis and developed recurrence after conventional chemoradiotherapy.
Liquidity risk and CMBX microstructure
Authors: Christopoulos Andreas D. , Barratt Joshua G. 
Published: January 2024

AbstractThis is the first paper in the literature to focus on CMBX price formation with dual techniques of liquidity estimation. In this paper, we introduce a generalizable method using principal component analysis to estimate daily risk decompositions of default, interest rate, liquidity and excess liquidity from previously simulated reduced form monthly risk decompositions. Our method generates these measures for CMBX. To assess liquidity estimates, we compare our risk decomposition measures of liquidity to classical microstructure effective bid–ask spreads, daily. We find our measures to be significant in explaining effective bid–ask spreads over 12 years of daily history and in 20‐day forecasts.
Stabilization of discrete‐time positive switched linear systems: A nonzero elements chain method
Authors: Zhang Hao , Shi Lei , Yao Shaojie , Yan Shuaiming , Zhou Yi 
Published: January 2024

AbstractThis article studies the stability problem of discrete‐time positive switched linear systems by introducing a nonzero elements chain method. Compared to existing works, the highlight of this article is reflected in the inclusiveness of the subsystem, that is, each subsystem is allowed to be stable, marginally stable or even unstable. Some sufficient conditions depending on the characteristics of system matrices and the time‐dependent switching signals are established, so as to guarantee the exponential stability of positive switched linear systems. In addition, the main result is extended to the case of time‐varying delay. At last, the superiority of the obtained results is well verified by numerical examples.
Community and Social Support
Authors: Lin Chichun , Hwahng Sel J. 
Published: January 2024

AbstractLesbian, gay, bisexual, transgender, and queer (LGBTQ or LGBTQ+ if the latter context includes other identities) individuals tend to experience high levels of minority stress, which might increase their mental health challenges. Especially for LGBTQ individuals in low- and middle-income countries (LMICs), they might additionally experience inadequate access to physical and mental health services, limited financial support, low levels of education, and limited capacity of their governments to solve the societal oppression of this population, which can aggravate minority stress. Social support can buffer the negative effects of minority stress and allow someone to feel cared for, loved, esteemed, valued, and as belonging in their communities. This chapter presents a general overview of social support LGBTQ people may receive from their parents, siblings, school peers, teachers, intimate partners, and colleagues. We also describe the benefits of specific communities of LGBTQ-identifying people, including those who identify as a nonbinary gender, intersex, or asexual/aromantic; those with interests in BDSM, leather, or polyamory lifestyles; people living with HIV; LGBTQ youth and seniors; and virtual and religious communities.
Single cell multi-omics of fibrotic kidney reveal epigenetic regulation of antioxidation and apoptosis within proximal tubule
Authors: Chen Zhejun , Ye Liqing , Zhu Minyan , Xia Cong , Fan Junfen , Chen Hongbo , Li Zhijian , Mou Shan 
Published: January 2024

Abstract
Background
Until now, there has been no particularly effective treatment for chronic kidney disease (CKD). Fibrosis is a common pathological change that exist in CKD.

Methods
To better understand the transcriptional dynamics in fibrotic kidney, we make use of single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq) and single-cell RNA sequencing (scRNA-seq) from GEO datasets and perform scRNA-seq of human biopsy to seek possible transcription factors (TFs) regulating target genes in the progress of kidney fibrosis across mouse and human kidneys.

Results
Our analysis has displayed chromatin accessibility, gene expression pattern and cell–cell communications at single-cell level in kidneys suffering from unilateral ureteral obstruction (UUO) or chronic interstitial nephritis (CIN). Using multimodal data, there exists epigenetic regulation producing less Sod1 and Sod2 mRNA within the proximal tubule which is hard to withstand oxidative stress during fibrosis. Meanwhile, a transcription factor Nfix promoting the apoptosis-related gene Ifi27 expression found by multimodal data was validated by an in vitro study. And the gene Ifi27 upregulated by in situ AAV injection within the kidney cortex aggravates kidney fibrosis.

Conclusions
In conclusion, as we know oxidation and apoptosis are traumatic factors during fibrosis, thus enhancing antioxidation and inhibiting the Nfix-Ifi27 pathway to inhibit apoptosis could be a potential treatment for kidney fibrosis.
Künstliche Intelligenz in der Orthopädie
Authors: Mathis Dominic , Ackermann Jakob , Günther Daniel , Laky Brenda , Deichsel Adrian , Schüttler Karl Friedrich , Wafaisade Arasch , Eggeling Lena , Kopf Sebastian , Münch Lukas , Herbst Elmar 
Published: January 2024

ZusammenfassungWir befinden uns in einer Phase exponentiellen Wachstums bei der Nutzung von künstlicher Intelligenz (KI). Knapp 90 % der KI-Forschung in der Orthopädie und Unfallchirurgie wurde in den letzten 3 Jahren veröffentlicht. In der Mehrzahl der Untersuchungen wurde KI zur Bildinterpretation oder als klinisches Entscheidungsinstrument eingesetzt. Die am häufigsten untersuchten Körperregionen waren dabei Wirbelsäule, Knie und Hüfte. Mit der Verbesserung der Datenerfassung verbessern sich auch die mit KI assoziierten Möglichkeiten einer genaueren Diagnostik, von patientenspezifischen Behandlungsansätzen, verbesserter Ergebnisvorhersage und erweiterter Ausbildung. KI bietet einen potenziellen Weg, um Ärztinnen und Ärzte zu unterstützen und gleichzeitig den Wert der Behandlung zu maximieren. Ein grundlegendes Verständnis dafür, was KI beinhaltet und wie sie sich auf die Orthopädie und die Patientenversorgung auswirken kann, ist unerlässlich. Dieser Artikel gibt einen Überblick über die Anwendungsbereiche von KI-Systemen in der Orthopädie und stellt sie in den komplexen Gesamtkontext bestehend aus Interessensvertretern aus Politik, Industrie, Behörden und Medizin.
Local Well-Posedness of the Skew Mean Curvature Flow for Small Data in $$d\geqq 2$$ Dimensions
Authors: Huang Jiaxi , Tataru Daniel 
Published: January 2024

AbstractThe skew mean curvature flow is an evolution equation for d dimensional manifolds embedded in $${\mathbb {R}}^{d+2}$$

R

d
+
2

(or more generally, in a Riemannian manifold). It can be viewed as a Schrödinger analogue of the mean curvature flow, or alternatively as a quasilinear version of the Schrödinger Map equation. In an earlier paper, the authors introduced a harmonic/Coulomb gauge formulation of the problem, and used it to prove small data local well-posedness in dimensions $$d \geqq 4$$

d
≧
4

. In this article, we prove small data local well-posedness in low-regularity Sobolev spaces for the skew mean curvature flow in dimension $$d\geqq 2$$

d
≧
2

. This is achieved by introducing a new, heat gauge formulation of the equations, which turns out to be more robust in low dimensions.
Classical Yang–Baxter Equation, Lagrangian Multiforms and Ultralocal Integrable Hierarchies
Authors: Caudrelier Vincent , Stoppato Matteo , Vicedo Benoît 
Published: January 2024

AbstractWe cast the classical Yang–Baxter equation (CYBE) in a variational context for the first time, by relating it to the theory of Lagrangian multiforms, a framework designed to capture integrability in a variational fashion. This provides a significant connection between Lagrangian multiforms and the CYBE, one of the most fundamental concepts of integrable systems. This is achieved by introducing a generating Lagrangian multiform which depends on a skew-symmetric classical r-matrix with spectral parameters. The multiform Euler–Lagrange equations produce a generating Lax equation which yields a generating zero curvature equation. The CYBE plays a role at three levels: (1) it ensures the commutativity of the flows of the generating Lax equation; (2) it ensures that the generating zero curvature equation holds; (3) it implies the closure relation for the generating Lagrangian multiform. The specification of an integrable hierarchy is achieved by fixing certain data: a finite set $$S\subset \mathbb {C}P^1$$

S
⊂
C

P
1

, a Lie algebra $$\mathfrak {g}$$
g
, a $$\mathfrak {g}$$
g
-valued rational function with poles in S and an r-matrix. We show how our framework is able to generate a large class of ultralocal integrable hierarchies by providing several known and new examples pertaining to the rational or trigonometric class. These include the Ablowitz–Kaup–Newell–Segur hierarchy, the sine-Gordon (sG) hierarchy and various hierarchies related to Zakharov–Mikhailov type models which contain the Faddeev–Reshetikhin (FR) model and recently introduced deformed Gross–Neveu models as particular cases. The versatility of our method is illustrated by showing how to couple integrable hierarchies together to create new examples of integrable field theories and their hierarchies. We provide two examples: the coupling of the nonlinear Schrödinger system to the FR model and the coupling of sG with the anisotropic FR model.
Variability of corticospinal and spinal reflex excitability for the ankle dorsiflexor tibialis anterior across repeated measurements in people with and without incomplete spinal cord injury
Authors: Brangaccio J. A. , Phipps A. M. , Gemoets D. E. , Sniffen J. M. , Thompson Aiko K. 
Published: January 2024

AbstractTo adequately evaluate the corticospinal and spinal plasticity in health and disease, it is essential to understand whether and to what extent the corticospinal and spinal responses fluctuate systematically across multiple measurements. Thus, in this study, we examined the session-to-session variability of corticospinal excitability for the ankle dorsiflexor tibialis anterior (TA) in people with and without incomplete spinal cord injury (SCI). In neurologically normal participants, the following measures were obtained across 4 days at the same time of day (N = 13) or 4 sessions over a 12-h period (N = 9, at 8:00, 12:00, 16:00, and 20:00): maximum voluntary contraction (MVC), maximum M-wave and H-reflex (Mmax and Hmax), motor evoked potential (MEP) amplitude, and silent period (SP) after MEP. In participants with chronic incomplete SCI (N = 17), the same measures were obtained across 4 days. We found no clear diurnal variation in the spinal and corticospinal excitability of the TA in individuals with no known neurological conditions, and no systematic changes in any experimental measures of spinal and corticospinal excitability across four measurement days in individuals with or without SCI. Overall, mean deviations across four sessions remained in a range of 5–13% for all measures in participants with or without SCI. The study shows the limited extent of non-systematic session-to-session variability in the TA corticospinal excitability in individuals with and without chronic incomplete SCI, supporting the utility of corticospinal and spinal excitability measures in mechanistic investigation of neuromodulation interventions. The information provided through this study may serve as the reference in evaluating corticospinal plasticity across multiple experimental sessions.
Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization
Authors: Hou Li-qiong , Liu Jun-Ru , Gu Jing-Li , Chen Mei-Lan , Kuang Li-Fen , Huang Bei-Hui , Zou Wai-yi , Li Juan 
Published: January 2024

AbstractHigh-dose cyclophosphamide (HD-Cy) (3 g/m2) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem cell (PBSC) mobilization. Unfortunately, it is associated with an increased risk of neutropenic fever (NF). We analyzed the effect of NF on PBSC apheresis results and the efficacy of prophylactic antibiotics for the prevention of NF associated with HD-Cy plus G-CSF for PBSC mobilization in patients with newly diagnosed multiple myeloma (MM). First, patients were divided into NF ( +) and NF ( −) groups according to whether they suffered from NF during mobilization. Second, we divided patients into an antibiotic prophylaxis group and a nonantibiotic prophylaxis group according to whether antibiotic prophylaxis was used during the mobilization period. Our study showed that NF( +) patients (n = 44) had lower CD34 + cell dose collection (median 2.60 versus 5.34 × 106/kg, P < 0.001) and slower neutrophil engraftment and platelet engraftment (median 11 versus 10 days, P = 0.002, and median 13 versus 11 days, P = 0.043, respectively) than NF( −) patients (n = 234). Of note, the nonantibiotic prophylaxis group patients (n = 30) had a 26.7% incidence of NF. In the patients receiving antibiotic prophylaxis (n = 227), the incidence was reduced to 9.3% (P = 0.01). The antibiotic prophylaxis patients had higher CD34 + cell collection (median 5.41 versus 2.27 × 106/kg, P < 0.001) and lower hospitalization cost of mobilization ($ median 3108.02 versus 3702.39, p = 0.012). Thus, our results demonstrate that NF is associated with lower CD34 + cell collection and that antibiotic prophylaxis can reduce the incidence of NF and improve stem cell mobilization and collection outcomes, which reduces the hospitalization cost of mobilization.
Interacting with autistic virtual characters: intrapersonal synchrony of nonverbal behavior affects participants’ perception
Authors: Bloch Carola , Tepest Ralf , Koeroglu Sevim , Feikes Kyra , Jording Mathis , Vogeley Kai , Falter-Wagner Christine M. 
Published: January 2024

AbstractTemporal coordination of communicative behavior is not only located between but also within interaction partners (e.g., gaze and gestures). This intrapersonal synchrony (IaPS) is assumed to constitute interpersonal alignment. Studies show systematic variations in IaPS in individuals with autism, which may affect the degree of interpersonal temporal coordination. In the current study, we reversed the approach and mapped the measured nonverbal behavior of interactants with and without ASD from a previous study onto virtual characters to study the effects of the differential IaPS on observers (N = 68), both with and without ASD (crossed design). During a communication task with both characters, who indicated targets with gaze and delayed pointing gestures, we measured response times, gaze behavior, and post hoc impression formation. Results show that character behavior indicative of ASD resulted in overall enlarged decoding times in observers and this effect was even pronounced in observers with ASD. A classification of observer’s gaze types indicated differentiated decoding strategies. Whereas non-autistic observers presented with a rather consistent eyes-focused strategy associated with efficient and fast responses, observers with ASD presented with highly variable decoding strategies. In contrast to communication efficiency, impression formation was not influenced by IaPS. The results underline the importance of timing differences in both production and perception processes during multimodal nonverbal communication in interactants with and without ASD. In essence, the current findings locate the manifestation of reduced reciprocity in autism not merely in the person, but in the interactional dynamics of dyads.