bluuebunny/crossref_metadata_2025_split huggingface dataset:
De lo vivo a lo pintado. Dinámicas territoriales y representaciones culturales en una comarca mediterránea / From the living to the painting. Territorial dynamics and cultural representations in a Mediterranean region
Authors: Gómez Moreno María Luisa , Zayas Fernández Belén , Reyes Corredera Sergio 
Published: January 2024

El litoral mediterráneo experimenta tensiones crecientes ejercidas por la difusión de nuevos usos urbanos y agrarios que amenazan sus valores ambientales y patrimoniales. Este artículo explora las posibilidades del concepto sistema GTP (geosistema, territorio y paisaje)como instrumento de apoyo para la regulación de estos procesos en la comarca de la Axarquía (Málaga, España) con el objetivo de armonizar valores culturales, económicos y ambientales.La côte méditerranéenne connaît des tensions croissantes dues à la diffusion de nouveaux usages urbains et agricoles qui menacent ses valeurs environnementales et patrimoniales. Cet article explore les possibilités du concept de système GTP (géosystème, territoire et paysage) en tant qu’instrument de soutien pour la régulation de ces processus dans la région d’Axarquía (Malaga, Espagne) dans le but d’harmoniser les valeurs culturelles, économiques et environnementales.The Mediterranean coast is under increasing tensions exerted by the diffusion of new urban and agricultural uses that menace its environmental and heritage values. This article explores the possibilities of the GTP system concept (geosystem, territory and landscape) as a support instrument for the regulation of these processes in the Axarquía region (Malaga, Spain) with the aim of harmonizing cultural, economic and environmental values.
Specifics of cystic fibrosis genetic spectrum in Georgia
Authors: Khurtsilava Ia , Agladze Dodo , Parulava Tsitsino , Margvelashvili Lali , Kvlividze Oleg 
Published: January 2024

Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). F508del is the most common mutation in the world. Other mutations are rare and population specific. The study aimed to comprehensively analyze the distribution of CFTR mutations in Georgian CF patients. Knowing the prevalence and characteristics of specific mutations can be reflected in genetic counseling and management strategies. We reviewed the data of 129 CF patients, aged &#60; 18 years, from all parts of Georgia. 91 patients with a clinically confirmed CF diagnosis were tested for CF-causing mutations (constituting 70.5% of all currently registered CF patients in the country). These patients have been analyzed for rare CFTR variants by massively parallel sequencing of the entire CFTR coding region and adjacent introns combined with the analysis of intra-CFTR rearrangements. CFTR gene analysis revealed 29 mutations in Georgian CF patients. The most common mutation was c.1545_1546delTA (1677delTA) with a frequency of 42.7%, while the second most common mutation, W1282X, was detected in 11.2% of all CF alleles. Another 27 CFTR mutations have low frequency, including F508del (6.7% of alleles). 3 novel mutations were found (c.708dupT; CFTRdele16_17; c.3170C&#62;G) and reported to CFTR2 database.According to the data, the distribution of CFTR mutations in the Georgian CF population differs regarding the high frequency of mutation c.1545_1546delTA (1677delTA) and the low frequency of the predominant F508del mutation. Compared to patients with F508 del and W1282X mutations, patients with 1677delTA have typical manifestations and complications; however, the frequency of growth retardation and liver damage is 3 times, and the frequency of chronic respiratory manifestations and chronic malnutrition is 2 times lower, though pancreatic insufficiency is more severe in patients with 1677delTa. CF-associated diabetes, distal intestinal obstruction syndrome, and hemoptysis were only observed in patients with the 1677delTA mutation. The mortality rate is lower compared to patients with F508del and W1282X mutations.
Study of bacteriological profile and antibiotic susceptibility pattern of pus isolates in tertiary care hospital
Authors: Sajjanar Vijetha , DE Premalatha , KC Siddesh , N Prakash 
Published: January 2024

Surgical wound causes invasion of pathogens causing surgical site infections which are commonly polymicrobial in nature. This pus forming infection causes delayed wound healing, wound dehiscence and wound breakdown contributing to important healthcare associated infections (HAI) Multidrug resistance has emerged among organisms isolated in pus sample due to failure of appropriate use of antibiotics.: 1. To study the bacteriological profile of pus samples 2. To determine the antibiotic susceptibility pattern of isolated pathogens from pus samples.The study was conducted in department of microbiology, Shimoga institute of medical sciences, Shimoga from January 2018 to June 2018.All pus samples were processed on blood agar, MacConkey agar and incubated at 37°c under aerobic conditions for 24 hours. The organisms were identified as per standard conventional methods. The antimicrobial susceptibility tests were done by Kirby–Bauer’s Disk Diffusion method on Mueller–Hinton Agar and interpreted as per clinical laboratory standard institution guidelines (CLSI). Out of 350 samples 250 were culture positive 100 were culture negative. Among culture positive most common organism isolated was followed by 86(34.45%), 72(28.8%), 55(22%), 20(8%), 9(3.6%), 2(0.8%), 3(1.2%) 3(1.2%), 3(1.2%). Gram positive organisms were most sensitive for linezolid, vancomycin and least sensitive to cefoxitin, erythromycin. Gram Negative Organisms Were Most Sensitive for Imipenam, Piperacillin tazobactam and least Sensitive for Ampicillin-sulbactam, Ciprofloxacin is most common etiology of pus forming infection most importantly surgical site infections (SSI). MRSA prevalence in hospital set up indicates the failure of proper infection control practices implementation in the hospitals causing healthcare associated infections (HAI). Emergence of multidrug resistance among the pus isolates is because of non-judicious use of antibiotics.
Piedra blanca: micosis superficial en un paciente pediátrico
Authors: Baquedano Ordoñez Abner Bladimir , Aguilar Gutiérrez Katia , Gómez Sosa Keshia Danae , Sierra Aguilar Sonia Ivana , Villanueva Ordoñez Josué David 
Published: January 2024

ANTECEDENTES: La piedra blanca es una micosis superficial crónica causada por hongos de levadura del género Trichosporon. Es una infección rara, asintomática y crónica que afecta el cabello externamente, sin invadirlo; aparece en forma de nódulos adherentes, blandos y blanquecinos. Se localiza principalmente en la cabeza, pero puede afectar otras áreas en menor frecuencia.
CASO CLÍNICO: Paciente pediátrica de 5 años, con dermatosis de 6 meses de evolución, localizada en piel cabelluda, caracterizada por nódulos asintomáticos, de 2 a 3 mm, de consistencia firme, blanquecinos, adherentes, que rodeaban el tallo del cabello en intervalos irregulares; recibió múltiples fármacos, como pediculosis resistente a tratamiento. Se llevaron a cabo estudios del pelo afectado (examen directo con KOH y cultivo por hongos). Se confirmó el diagnóstico de piedra blanca por Trichosporon cutaneum. Se brindó tratamiento tópico, con resultados satisfactorios luego de tres meses.
CONCLUSIONES: Existen enfermedades que producen lesiones nodulares en el pelo; por tanto, debe considerarse la piedra blanca dentro del diagnóstico diferencial, y efectuar en la medida de lo posible el abordaje integral y oportuno, para evitar el retraso en el diagnóstico, implementar tratamientos inadecuados y costos innecesarios a los pacientes.
Síndrome de Cushing iatrogénico y síndrome de supresión de esteroides por la prescripción de conticosteroides tópicos
Authors: Jaime Sànchez Myriam Azucena 
Published: January 2024

ANTECEDENTES: Los corticosteroides tópicos representan uno de los tratamientos de primera línea de diversas enfermedades dermatológicas, debido a su efecto antiinflamatorio y antiproliferativo. Cuando se aplican de forma adecuada son seguros y eficaces; no obstante, la exposición prolongada puede producir efectos secundarios graves.
CASO CLÍNICO: Paciente femenina de 1 año y 7 meses, quien manifestó síndrome de Cushing iatrogénico y síndrome de supresión esteroidea por uso crónico y no supervisado de corticosteroides por vía tópica en el área del pañal.
CONCLUSIONES: Los corticoides tópicos son fármacos efectivos para el tratamiento de múltiples afecciones de la piel. El conocimiento de su prescripción es fundamental; por lo tanto, conocer los efectos adversos y el perfil de seguridad es imprescindible para la práctica pediátrica diaria.
Pancasila and Citizenship Education Learning Model for Elementary School Students: A Literature Review
Authors: Retnasari Lisa , Hidayah Yayuk , Mulyoto Galih Puji , Istianah Anif 
Published: January 2024

Model pembelajaran merupakan kerangka konseptual yang digunakan guru dalam mengorganisir pembelajaran. Model pembelajaran dianggap mampu mengatasi permasalahan yang timbul dalam proses pembelajaran terjadi. Model pembelajaran yang inovatif akan memudahkan dalam mencapai tujuan pembelajaran yang dirumuskan.Penelitian ini secara khusus bertujuan untuk mengetahui model pembelajaran PPKn SD. Jenis penelitian ini adalah kualitatif studi literatur. Hasil penelitian menunjukan bahwa model pembelajaran yang tepat dalam PPKn SD ialah 1) Value Clarification Technique (VCT), 2) Analisis kasus, 3) Contextual Teaching and Learning (CTL), 4) Problem Based Learning (PBL).
HUBUNGAN MANAJEMEN WAKTU BELAJAR DENGAN PRESTASI BELAJAR MENUJU ERA SOCIETY 5.0 [THE RELATIONSHIP OF STUDY TIME MANAGEMENT WITH LEARNING ACHIEVEMENT TOWARDS THE ERA OF SOCIETY 5.0]
Authors: Nurlaila Nugraheni , Rigianti Henry Aditia 
Published: January 2024

<p><span id="speechify-first-word-listening-nudge-49"><span id="speechify-first-word-listening-nudge-49"><span id="speechify-first-word-listening-nudge-36"><span id="speechify-first-word-listening-nudge-36">Studying time management</span></span></span></span> is the management of learning opportunities. This governance is very important as an effort to improve learning achievement. The method used by researchers is literature review. From this research and literature review, results include that students who manage training duration are able to achieve or increase training manifestations substantially. By managing the training period, students become more determined in carrying out training.</p><div class="speechify-ipvczq"> </div><div class="speechify-ipvczq"><strong><span class="speechify-1pieqac">Bahasa Indonesia Abstrak</span></strong></div><p>Manajemen waktu belajar merupakan tata kelola kesempatan dalam belajar. Tata Kelola ini sangat penting sebagai upaya meningkatkan prestasi belajar. Metode yang peneliti tempuh ialah kajian literatur. Dari penelitian dengan kajian pustaka ini membuahkan hasil antara lain siswa yang melakukan pengelolaan durasi pelatihan mampu meraih atau meningkatkan manifestasi pelatihan dengan substansial. Dengan melakukan pengelolaan masa pelatihan, siswa menjadi lebih bertekat dalam melakukan pelatihan.</p>
Xanthophore Distribution of Nemo (Amphiprion ocellaris) Skin Based on various Concentrations of Carotenoid Sources
Authors: Pratiwi Rini , Karim Muhammad Yusri , Trijuno Dody Dh 
Published: January 2024

Abstract
The decreased color intensity of Nemo is related to the amount of carotenoid concentration in the xanthophore of Nemo’s skin. Therefore, efforts are needed to maintain stable carotenoid production. Tomato is one of the most abundant carotenoid producers. The utilization of carotenoids can maintain the morphological color of aquatic organisms. This study aimed to analyze the effect of carotenoid compounds on total carotenoid content, the size, and distribution of xanthophores on Nemo skin. A total of 60 Nemo with an average initial weight of 0.84±0.14 g and an average length of 2.95±0.08 cm. The research was conducted using a completely randomized design (CRD), consisting of four carotenoid concentrations in addition to fish pellet, 0%, 0.5%, 1%, and 1.5% with three replications. The results showed that the optimum dose of carotenoid compounds in increasing the total carotenoid content in nemo fish skin is 1.5%. Carotenoids added to the fish feed affected the distribution and maturity of xanthophore. However, it did not affect the size of the xanthophore.
Highlight Research

Nemo contains three types of pigment cells, namely melanophores, xanthophores, and iridophores.
Carotenoid supplementation is related to xanthophore in fish skin
The pigment pattern is determined mainly by the number, size, and distribution of different cell types
xanthophores were not found in the histology HE (hematoxylin-eosin) staining method in fish skin.
Effect of M-CSF on the expression of endothelial progenitor cell markers in blood mononuclear cell culture in coronary heart disease
Authors: Chumakova S. P. , Urazova O. I. , Shipulin V. M. , Gladkovskaya M. V. , Andreev S. L. , Nevskaya K. V. , Zima A. P. , Nikulina E. L. 
Published: January 2024

Aim. To evaluate the nature of changes in the expression of markers of endothelial progenitor cells (VEGFR2, CD34, CD14) and endothelial cells (CD146) in association with the expression of the leukocyte common antigen CD45 in the culture of blood mononuclear cells in the presence of M-CSF in patients with coronary heart disease (CHD) and healthy donors.Materials and methods. The study included 12 patients with CHD with class III–V angina pectoris and 10 healthy donors, from whom 30 ml of venous blood was taken on an empty stomach in the morning and stabilized with heparin. Blood mononuclear cells were isolated by Ficoll density gradient centrifugation (1.077 g / cm3) and subject to immunomagnetic separation using CD14-MicroBeads and CD34-MicroBead Kit (Miltenyi Biotec B.V. & Co. KG, Germany). The resulting CD14+ and CD34+ culture of mononuclear cells was incubated for 6 days in a complete nutrient medium with and without M-CSF 50 ng / ml (Cloud-Clone Corp., USA) with complete replacement of the medium and repeated application of M-CSF on day 3. After 6 days, the proportions of CD45+, CD14+, CD34+, VEGFR2+, and CD146+ cells in the culture were assessed by flow cytometry using CD14-FITC, CD34-PE, VEGFR2-Alexa Fluor 647; CD45-FITC and CD146-PerCP antibodies (BD Biosciences, USA).Results. It was shown that in healthy donors, the proportion of CD146+ cells in the co-culture of blood mononuclear cells with M-CSF exceeded their number in the sample without it, with comparable expression rates of CD45, CD14, and VEGFR2 markers between the control and stimulated cultures. In CHD patients, the number of CD146+ and VEGFR2+ cells did not change when M-CSF was added to the mononuclear cell culture; however, the proportion of CD14+ cells increased and the proportion of CD45+ cells decreased compared to the control sample. The number of CD34+ cells was comparable both between control and stimulated samples, and between the groups of examined individuals. At the same time, in patients with CHD, an increased proportion of VEGFR2+ cells was found in the control and stimulated samples compared to healthy individuals, while an increased proportion of CD14+ cells was detected only in the stimulated culture.Conclusion. The development of CHD disrupts the response of blood mononuclear cells to the effect of M-CSF, increasing the number of CD14+ and reducing the proportion of CD45+ cells in the culture in the absence of stimulating effects on the expression of endothelial cell marker CD146. At the same time, M-CSF does not affect the expression of CD34 and VEGFR2 in endothelial progenitor cells both in patients with CHD and in healthy individuals.
Notch signaling pathway in the development of imbalanced immune responses in patients with disseminated pulmonary tuberculosis
Authors: Sanina A. E. , Serebryakova V. A. , Urazova O. I. , Gadzhiev A. A. 
Published: January 2024

Aim. To determine the role of the Notch signaling pathway in the regulation of Th1 / Th2 lymphocyte balance in patients with disseminated drug-sensitive (DS) and drug-resistant (DR) pulmonary tuberculosis (PT).Materials and methods. Mononuclear leukocytes were isolated from the venous blood of 13 patients with disseminated PT by density gradient centrifugation. The cells were cultured for 72 h in the complete cell culture medium at 5% CO2 and 37 °C. Preliminarily, CFP10 and ESAT6 mycobacterial antigens or γ-secretase inhibitor DAPT (5 μM / l; 10 μM / l) together with CFP10 and ESAT6 antigens were added to the culture medium. Immunophenotyping of Th1 and Th2 lymphocytes was performed by multicolor flow cytometry by determining the expression of CD4 receptor and intracellular transcription factors T-bet and GATA-3.Results. In patients with disseminated DS and DR PT, an increase in the number of Th1 and Th2 lymphocytes was found in intact cultures. Stimulation of cells with mycobacterial antigens CFP10 and ESAT6 resulted in an increase in the number of CD4+T-bet+ and CD4+GATA-3+ cells in all comparison groups. Addition of CFP10 and ESAT6 antigens and DAPT (10 μM / l) to the incubation medium was accompanied by a decrease in the number of Th2 lymphocytes in PT patients in both groups. A rise in the number of Th1 cells was registered only in patients with DS PT. Suppression of the Notch signaling pathway with the γ-secretase inhibitor DAPT (10 μM / l) resulted in an increase in the Th1 / Th2 lymphocyte balance in both DS and DR variants of the disease.Conclusion. The Notch signaling pathway has a modulating effect on the differentiation of the key lymphocyte populations that determine the balance between cell-mediated and humoral immune responses to PT. Suppression of the Notch signaling cascade by the γ-secretase inhibitor DAPT (10 μM / l) in vitro promotes an increase in the Th1 / Th2 ratio in patients with disseminated DS and DR PT. The positive regulatory effect on the Th1 / Th2 lymphocyte balance allows to consider the Notch signaling pathway as a promising potential target in the development of new approaches to the pathogen-specific therapy for PT.
Flipped Book Based E-Module Interactive to Develop Meat Processing Technology Learning Media
Authors: Cakrawati Dewi - , Fitri Dewi - , Rahayu Dwi Lestari 
Published: January 2024

<p>The application of interesting learning media during the learning process is important to increase student enthusiasm which leads to increasing students’ cognitive results. This study aimed to develop meat processing technology learning media using a flipped-book based e-module interactive. Meat processing technology was one of the subjects for students in class XI Agribusiness vocational high school. The learning media was developed based on the research and development method by applying the ADDIE model that consists of five steps: Analysis, <em>Design</em>, <em>Development</em>, <em>Implementation</em> dan <em>Evaluation</em>. The learning media was validated by judgment experts namely computer teacher, language teacher, and subject-related teacher. The instruments used for validation were questionnaires with a Likert scale from 1-to 4. Judgment expert validation showed the learning media was qualified based on content (95.45%), language (95.83%), and features (86.67%). Features of media had the lowest grade according to judgment experts since several improvements were needed namely repairing the media cover, changing the font color to brighter color, give different colors to the font to differentiate the menu in the e-module. The media was improved based on suggestions from judgment experts before being used as learning media for meat processing technology subjects.</p>
The Relationship between Students' Searning Interest and Learning Outcome
Authors: Wahdi Anang Saiful , Effendi Agus , Khurniawati Wiji 
Published: January 2024

<p>Penelitian ini bertujuan untuk mengetahui pengaruh minat belajar terhadap hasil belajar siswa pada sekolah vokasi jurusan pengembang perangkat lunak &amp; gim di salah satu sekolah kejuruan daerah Surakarta. Metode yang digunakan dalam penelitian ini adalah metode survei dengan pendekatan kuantitatif-kualitatif. </p><p> </p>
Spinal Epidural Tuberculoma with Adjacent Vertebral Fracture
Authors: Kageshima Koutaro , Nagai Sota , Kawabata Soya , Ito Kei , Takeda Hiroki , Ikeda Daiki , Kaneko Shinjiro , Fujita Nobuyuki 
Published: January 2024

Case:
An 85-year-old woman was transported to our institution due to difficulty in walking. Preoperative imaging showed spinal cord lesions indicative of spinal cord tumor at the T7-8 level, accompanied by T8 vertebral fracture. Intraoperatively, the spinal lesion was suspected to be an epidural abscess; therefore, the capsule was resected, and the abscess was drained. We added pedicle screw fixation at the T6-10 level. Postoperatively, the spinal cord lesion was definitively diagnosed as spinal epidural tuberculoma.

Conclusion:
Spinal epidural tuberculomas should be considered in the treatment of spinal cord lesions causing paralysis attributed to spinal cord compression.
The Effect of Mood on Shaping Belief and Recollection Following False Feedback
Authors: Li Chunlin , Otgaar Henry , Battista Fabiana , Muris Peter , Zhang Yikang 
Published: January 2024

Abstract
The current study examined how mood affects the impact of false feedback on belief and recollection. In a three-session experiment, participants first watched 40 neutral mini videos, which were accompanied by music to induce either a positive or negative mood, or no music. Following a recognition test, they received false feedback to reduce belief in the occurrence of the events displayed in some of the videos (Session 2). This was followed by an immediate memory test and a delayed memory assessment one week later (Session 3). The results revealed that participants in negative mood reported higher belief scores compared to those in positive moods, despite an overall decline in belief scores for all groups following the false feedback. Notably, individuals in negative moods exhibited less reduction in their belief scores after encountering challenges, thereby maintaining a higher accuracy in their testimonies. Over time, a reduction in the clarity of participants’ memory recall was observed, which correspondingly reduced their testimony accuracy. This study thus indicates that mood states play a role in shaping belief and memory recall under the influence of false feedback.
A universal strategy to induce oxidative stress-mediated cell death in biological systems
Authors: Möckl Leonhard , Almahayni Karim , Salvador Jana Bachir , Conti Riccardo , Widera Anna , Spiekermann Malte , Wehner Daniel , Grützmacher Hansjörg 
Published: January 2024

Abstract
Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and the expansive reactivity of chemical agents. Current platforms are often limited by their complexity, toxicity, and poor physical/chemical properties. Here, we integrate the spatio-temporal precision of light delivery and the structural versatility of bisacylphosphane oxides (BAPOs), establishing a universal strategy for on-demand, precise cellular ablation in vitro and in vivo.