bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of novel biomarkers for the prediction of subclinical coronary artery atherosclerosis in patients with rheumatoid arthritis: an exploratory analysis
Authors: Bathon Joan M. , Centola Michael , Liu Xiaoqian , Jin Zhicheng , Ji Weihua , Knowlton Nicholas S. , Ferraz-Amaro Iván , Fu Qin , Giles Jon T. , Wasko Mary Chester , Stein C. Michael , Van Eyk Jennifer E. 
Published: October 2023

Abstract
Background
Cardiovascular (CV) risk estimation calculators for the general population underperform in patients with rheumatoid arthritis (RA). The purpose of this study was to identify relevant protein biomarkers that could be added to traditional CV risk calculators to improve the capacity of coronary artery calcification (CAC) prediction in individuals with RA. In a second step, we quantify the improvement of this prediction of CAC when these circulating biomarkers are added to standard risk scores.

Methods
A panel of 141 serum and plasma proteins, which represent a broad base of both CV and RA biology, were evaluated and prioritized as candidate biomarkers. Of these, 39 proteins were selected and measured by commercial ELISA or quantitative mass spectroscopy in 561 individuals with RA in whom a measure of CAC and frozen sera were available. The patients were randomly split 50:50 into a training/validation cohort. Discrimination (using area under the receiver operator characteristic curves) and re-classification (through net reclassification improvement and integrated discrimination improvement calculation) analyses were performed first in the training cohort and replicated in the validation cohort, to estimate the increase in prediction accuracy for CAC using the ACA/AHA (American College of Cardiology and the American Heart Association) score with, compared to without, addition of these circulating biomarkers.

Results
The model containing ACC/AHA score plus cytokines (osteopontin, cartilage glycoprotein-39, cystatin C, and chemokine (C–C motif) ligand 18) and plus quantitative mass spectroscopy biomarkers (serpin D1, paraoxonase, and clusterin) had a statistically significant positive net reclassifications index and integrated discrimination improvement for the prediction of CAC, using ACC/AHA score without any biomarkers as the reference category. These results were confirmed in the validation cohort.

Conclusion
In this exploratory analysis, the addition of several circulating CV and RA biomarkers to a standard CV risk calculator yielded significant improvements in discrimination and reclassification for the presence of CAC in individuals with RA.
Multivariable prediction models of caries increment: a systematic review and critical appraisal
Authors: Havsed Kristian , Hänsel Petersson Gunnel , Isberg Per-Erik , Pigg Maria , Svensäter Gunnel ,   the Foresight Research Consortium, Rohlin Madeleine 
Published: October 2023

Abstract
Background
Multivariable prediction models are used in oral health care to identify individuals with an increased likelihood of caries increment. The outcomes of the models should help to manage individualized interventions and to determine the periodicity of service. The objective was to review and critically appraise studies of multivariable prediction models of caries increment.

Methods
Longitudinal studies that developed or validated prediction models of caries and expressed caries increment as a function of at least three predictors were included. PubMed, Cochrane Library, and Web of Science supplemented with reference lists of included studies were searched. Two reviewers independently extracted data using CHARMS (Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies) and assessed risk of bias and concern regarding applicability using PROBAST (Prediction model Risk Of Bias ASessment Tool). Predictors were analysed and model performance was recalculated as estimated positive (LR +) and negative likelihood ratios (LR −) based on sensitivity and specificity presented in the studies included.

Results
Among the 765 reports identified, 21 studies providing 66 prediction models fulfilled the inclusion criteria. Over 150 candidate predictors were considered, and 31 predictors remained in studies of final developmental models: caries experience, mutans streptococci in saliva, fluoride supplements, and visible dental plaque being the most common predictors. Predictive performances varied, providing LR + and LR − ranges of 0.78–10.3 and 0.0–1.1, respectively. Only four models of coronal caries and one root caries model scored LR + values of at least 5. All studies were assessed as having high risk of bias, generally due to insufficient number of outcomes in relation to candidate predictors and considerable uncertainty regarding predictor thresholds and measurements. Concern regarding applicability was low overall.

Conclusions
The review calls attention to several methodological deficiencies and the significant heterogeneity observed across the studies ruled out meta-analyses. Flawed or distorted study estimates lead to uncertainty about the prediction, which limits the models’ usefulness in clinical decision-making. The modest performance of most models implies that alternative predictors should be considered, such as bacteria with acid tolerant properties.

Trial registration
PROSPERO CRD#152,467 April 28, 2020
Food wastes clean water wastes: melon peel peroxidase isolation and immobilization onto magnetite nanoparticles for phenol removal
Authors: Al-Madhagi Haitham , Yazbik Valantina , Abdelwahed Wassim 
Published: October 2023

AbstractIn this study, melon peel waste was utilized to isolate peroxidase enzyme through three-phase portioning (TPP) and subsequently immobilized onto magnetite nanoparticles for effective bioremediation of phenol pollutants from water. The optimization of TPP parameters ensured maximum activity recovery and enzyme purity. Magnetite nanoparticles were synthesized and used as a substrate for immobilizing the isolated peroxidase, achieving an activity recovery of 157% and a purification fold of 5.2. Protein homogeneity testing confirmed the purity of the peroxidase enzyme. The magnetite nanoparticles had an average diameter of 62 nm, and the immobilization efficiency reached 93% at pH 8 with an enzyme/nanoparticles v/v ratio of 1:9. The immobilized peroxidase demonstrated the ability to degrade 57% of phenol within 3 h and retained 30% relative activity even after five catalytic cycles. This immobilized melon peel peroxidase on magnetite nanoparticles proves to be a robust, enduring, and reusable biocatalyst with potential for various applications, especially in bioremediation processes.
Graphical Abstract
Resisting the Clockwork of Occupation
Authors: Falak Uzma 
Published: October 2023

Abstract
Despite its centrality as a locus of both occupation and resistance in Kashmir, the inquiry into time has received scant academic attention. This essay undertakes two lines of inquiry. First, it attempts to foreground the temporal extraction integral to the Indian state’s matrix of control, arguing that its military occupation and settler-colonial project in Kashmir operates not only through the logics of spatial control but also through a control over time. The state has not only tried to erase people out of their own futures but also weaponized the idea of future itself—as a site of a permanent and multimodal extraction. Second, Kashmir’s liberation praxis is anchored on a rejection of an occupational and settler-colonial temporal order and, through two ethnographic fragments, this essay explores enactments of alternate temporal imaginaries and consciousness and foregrounds multiple registers of “in-betweenness” within this imaginary. The essay redirects attention from future as an event or a discrete unit of time, and from its not-yetness, toward the intimate and everyday articulations and enactments of future—a complex ongoing process of becoming and unbecoming unfolding in the everyday. Thus the essay calls for reimagining “ruptures”—instead of “futures”—as a locus of liberation.
“I Am Very Sexy, Sexy, Sexy”
Authors: Fox Diana J. , Malik Shazia 
Published: October 2023

Abstract
This article focuses on the story of one transfeminine (transgen, in local parlance) wedding singer, Shabu, identifying through interviews, observation, and song analysis the possibilities of self-expression for transgens as well as for cisgender women who attend these performances. How have they carved out agency for themselves amid Kashmir’s territorial conflict over its sovereignty? The article demonstrates how Kashmiri gendered futures are intimately tied to courageous and innovative performances in women’s spaces, even within pronounced systemic constraints. Shabu’s songs concern women’s agency, gender dynamics and roles, family relationships, and gender presentation both in and outside women’s familial household and community/kin networks. The songs both embody accepted tradition and open doors to innovation, protest, and political commentary. The digital life of these performances on YouTube has contributed to their dissemination and popularity. This article addresses questions arising from shifting contexts of transgens’ wedding-song performances and contributes to the body of analysis of digital folklore through decolonial feminist and queer folkloristic lenses.
Digitalization As a Form of Innovative Development of the Real Estate Market
Authors: Gudimenko G. , Dorofeeva V. 
Published: October 2023

The article highlights the main trends in the innovative development of the Russian real estate market, which have emerged under the influence of the introduction of digitalization. It is shown that at present the real estate market is undergoing significant changes, moving to a new qualitative state. This is due to the emergence and introduction of innovative construction technologies, the global change in the types of urbanization, changes in the social requirements of the population, the improvement of legislative and organizational support for the functioning of the real estate market and, above all, the widespread use of digital technologies. The analysis of digital services used in the Russian real estate market is carried out. It is determined that a significant number of operations are involved in the process of managing real estate and infrastructure, which are subject to transformation and optimization through the use of innovative digital technologies. The existing problems of digitalization of the real estate market have been clarified and the key directions of their solution have been identified. It is concluded that digitalization will lead to a change in the behavior of all participants in the real estate market real estate market developers, sellers, tenants, agents, property owners.
As a result, the real estate market will become more open and transparent.
Probabilistic graphical modelling of early childhood caries development
Authors: Ugolini Alessandro , Porro Francesco , Carli Federico , Agostino Paola , Silvestrini-Biavati Armando , Riccomagno Eva 
Published: October 2023

In order to develop a statistical model for complex interactions among factors affecting early childhood caries development (ECC), 234 children from the “XXXX oral growth longitudinal study” were analysed at ages 3, 4 and 5. A questionnaire for children’s parents (clinical history, nutritional and oral hygiene habits) and clinical oral examinations were recorded each year. The probabilistic dependence structure on the most significant factors was modelled with an Undirected Graphical Model (UGM or Markov random fields) which provides a probabilistic reasoning approach for the establishment of multi-way associations. The best fitting UGM was estimated through the maximum likelihood principle and two-way factor associations were verified through Fisher’s exact statistical hypothesis tests for count data. The effect of sugar intake on caries incidence is mediated by oral hygiene; for caries incidence, oral hygiene quality is more relevant than toothbrushing time; the effect of pacifier on caries incidence is statistically significant only when considered in combination with breastfeeding time. Among behavioural ECC risk factors, the quality of oral hygiene, and not the toothbrushing frequency, is a primary factor that modulates the sugar intake in his primary role of the ECC developer. School-based oral health programs for ECC prevention should be improved with supervised toothbrushing program. UGM analysis could improve the school-based oral health programs with more effective and efficient prevention strategies based on the hierarchical interactions among the ECC risk factors. Oral hygiene plays a pivotal role in early childhood caries and can modulate positively or negatively their development. Supervised toothbrushing is a crucial intervention to be included in the daily educational and clinical practice and in the school-based oral health promotion programs.Trial registration: Clinical trial registration number:NCT02798809.
Pengembangan Modul Kimia berbasis Relating, Experiencing, Applying, Cooperating dan Transfering (REACT) bermuatan Etnokimia
Authors: Anisatul Insyiroh  
Published: October 2023

Penelitian pengembangan ini bertujuan untuk mengembangkan modul kimia berbasis relating, experiencing, applying, cooperating dan transferring (REACT) bermuatan etnokimia pada materi asam basa dan mengetahui kualitas produk berdasarkan penilaian ahli materi,ahli media, guru kimia dan respon peserta didik. Penelitian ini merupakan penelitian pengembangan (Research & Development) dengan model pengembangan ADDIE yang terdiri dari 5 tahap yaitu analysis, design, development, implementation, dan evaluation. Namun penelitian ini dibatasi sampai tahap ketiga yaitu development. Penilaian kualitas produk dilakukan oleh satu ahli materi, satu ahli media, empat guru Kimia SMA/MA dan direspon oleh sepuluh peserta didik SMA/MA. Instrumen penelitian berupa lembar penilaian kualitas produk dengan skala Likert dan lembar respon siswa skala Guttman. Teknik analisis data yang digunakan yaitu dengan mengubah data kualitatif menjadi data kuantitatif. Hasil produk pengembangan berupa modul berukuran B5 berisi materi asam basa yang disusun sesuai dengan rangkaian strategi pembelajaran REACT dan dilengkapi dengan muatan etnokimia. Hasil penilaian ahli materi memperoleh persentase 91,8% dengan kategori Sangat Baik (SB), penilaian ahli media memperoleh persentase 92,63% dengan kategori Sangat Baik (SB), dan penilaian guru Kimia SMA/MA memperoleh persentase 92,5% dengan kategori Sangat Baik (SB). Sedangkan respon peserta didik terhadap produk sangat positif dengan persentase 96,7%.
Bump feature detection of the road surface based on the Bi-LSTM
Authors: Lyu Haiyang , Xu Ke , Jiao Donglai , Zhong Qiqi 
Published: October 2023

Abstract
The road network is the basic facility for transportation systems in the city. Every day, a large number of vehicles move on the road and exert different pressure on the ground, which leads to various problems for the road surface, such as the bump features of the road surface (BFRS). However, traditional methods, such as detecting BFRS manually or with professional equipment, require a lot of professional management and devices. Based on the mobile sensor and the bidirectional long short-term memory (Bi-LSTM), a detection method for BFRS is proposed. The BFRS detection method proposed in this article solves the problem that other BFRS detection methods cannot detect large area road surface efficiently and provides an algorithm idea for efficient detection of large area road surface BFRS. The mobile phone with multi-sensors is carried on vehicles, and the BFRS information is logged during the movements. The orientation of the mobile is computed according to the gyroscope. The actual posture of the acceleration sensor is adjusted with the reference coordinate system, whose z-axis is vertical to the ground. This article uses the adjusted acceleration data as the training dataset and labels it according to time stamps and videos recorded by the driving recorder. Finally, the Bi-LSTM is constructed and trained, followed by the BFRS detection. The results show that it can detect BFRS in different regions. The detection accuracy of the campus section and the extended experiment was 92.85 and 87.99%, respectively.
Microwave-accelerated pretreatment technique in green extraction of oil and bioactive compounds from camelina seeds: Effectiveness and characterization
Authors: Mortazavi Pardis , Azadmard-Damirchi Sodeif , Piravi-Vanak Zahra , Ahmadi Omid , Anarjan Navideh , Martinez Fleming , Jafarizadeh-Malmiri Hoda 
Published: October 2023

Abstract
The effect of microwave pretreatment and moisture levels of Camelina sativa seeds on the quality of extracted oil by cold press was investigated. The seed moistures were adjusted to 2.5%, 5.0%, 7.5%, and 10.0% and pretreated with microwaves for 0, 1, 2, and 3 min. Microwave pretreatment (3 min) of the seeds with 2.5% moisture increased the oil extraction yield by ∼11% compared to the control sample. The highest amount of acidity (0.564 g FFA·g−1 oil), peroxide value (2.4 meq O2·kg−1 oil), carotenoid (5.26 mg·kg−1 oil), and browning index (0.710) were found in the oil extracted from seeds with 10% moisture and 3 min microwave pretreatment. The total phenolic compound was increased by microwave pretreatment but was mitigated by the seed moisture content, and the highest amount (208.24 mg caffeic acid·100 g−1 oil) was observed at 3 min microwave pretreatment of the seeds with 2.5% moisture. Chlorophyll content decreased by both microwave pretreatment and seed moisture content in camelina oil. Generally, the fatty acid composition of the extracted oils was not affected by the seed pretreatments. In conclusion, pretreatment of the camelina seeds before oil extraction is suggested to obtain a high oil extraction yield with a good quality oil.
Molecular dynamics study on dynamic interlayer friction of graphene and its strain effect
Authors: Huang Jianzhang , Gan Shuang , Cai Yi , Liu Yijie , Liang Yingjing 
Published: October 2023

Abstract
This study delves into the mechanism of dynamic sliding friction between layers of graphene and its strain effect, through numerical analysis using molecular dynamics simulations. To eliminate the influence of commensurability and edge effect, a friction pair model with annular graphene as a slider is established. The research explores the quantifying effects of temperature, normal load, sliding velocity, support stiffness, and axial strain on the friction between graphene layers. The coupling effect of temperature and other influencing factors is also clarified. The results indicate that the interlayer friction increases with normal load by decreasing the interlayer spacing and increasing the atomic vibration amplitude. The ploughing phenomenon does not appear since the edge effect is eliminated by the model. Friction is initially enhanced at higher sliding velocities, but is later reduced by severe residual deformation and lattice resonance frequency. The support stiffness regulates interlayer friction by affecting the atomic vibration amplitude of the graphene lattice. Mechanism analysis shows that the number of effective contact atoms increases under axial strain, and the lattice vibration frequency is the main way to regulate the interlayer friction by strain effect. Our findings provide a fundamental understanding of the strains engineering of nanoscale friction and reveal the influence mechanism of affecting factors on the dynamic friction of graphene.
Weak Decisionism and Political Polytheology: The Neutralization of Carl Schmitt’s Political Theology by Hans Blumenberg and the Ritter School
Authors: Griffioen Sjoerd Laurens Victor 
Published: October 2023

Abstract
In this article, I explore the liberal–conservative reception of Carl Schmitt’s political theology in post-war West-Germany. By focusing on the work of prominent members of the Ritter School – Hermann Lübbe, Ernst-Wolfgang Böckenförde, and Odo Marquard – and on the contributions of Hans Blumenberg, I will demonstrate how Schmitt’s thought was appropriated and critically inverted, in order to provide theoretical support to liberalism. This project of liberalizing Schmitt involved developing a “weak decisionism,” which avoids the state of exception, providing a liberalist reading of Schmitt’s Hobbes-inspired narrative on the origin of the modern state and even formulating a “political polytheology.” Finally, this article offers a reflection on “political theology” as a conceptual field. I argue that the liberal–conservative, “neutralizing” reading of Schmitt is to some extent already available as an option within this framework, and I conclude that this finding problematizes Schmitt’s own dualistic antagonism.
Publishing Via Social Media Sites and The Civil Liability of the Publisher in The Jordanian Legislation
Authors: Migdad Mohammad Ali Mohammad Bani 
Published: October 2023

This study showed the adequacy of the legal regulation of civil liability resulting from publishing via social media sites, and it also showed the lack of legal texts that dealt with this subject, which raises many problems. Then the study dealt with the issue of civil liability for publishing via social media sites in the Jordanian law: the concept of civil liability, whether contractual or tort, the provisions of this responsibility, and then the pillars of civil liability (error, damage, and causal relationship). This study discussed the legal protection for electronic publishing and the compensation due, with the obligation to pay compensation and the consequences of it. The study concluded that it is necessary to conclude an international agreement that regulates the relationship to solve the problems that occur when the actual location of the data that led to electronic violations is in one country and the victim is in another. The Jordanian legislator is responsible for clearly and explicitly regulating the procedures affecting the sanctity of private life, by enacting a law regulating electronic publishing through social media sites. The law must regulate the amount of fair compensation commensurate with the electronic damage
Evaluating the Impact of Leader-Member Exchange (LMX) Theory on the Interactions Between Managers and Employees in Chosen Ghanaian Banking Institutions
Authors: Sulemana Iddrisu , Bawah Mohammed , Sadiq Mohammed Abubakari 
Published: October 2023

Purpose - The objective of this study is to explore how employee results, including job performance and job contentment, are linked to evaluations made by both employees and managers concerning the caliber of. the leader-member relationship (referred to as LMX). Design/Methodology/Approach – A correlational design and descriptive survey method were employed to collect data through a questionnaire administered to both superiors and their subordinates. The study utilized data from 10 banks to test the hypothesis. Findings: The study revealed a moderate link in relation to the exchanges within leader-member relationships and their impact on employee job performance. The investigation identified a minor but positive association between the motivation of employees and the efficacy of interactions between leaders and subordinates. The gender of leaders did not notably affect the caliber of interactions between leaders and followers.