bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facial cutaneous phaeohyphomycosis in an immunocompetent individual
Authors: Rana Neha , Sagar Tanu , Saxena Sonal , Chaudhary Kanika 
Published: January 2024

ABSTRACT
Fungal infection is a rare condition in immunocompetent individuals, and it is associated with high rates of morbidity and mortality. We report on a case of cutaneous phaeohyphomycosis in healthy 25-year-old man. Based on the clinical findings, the case was first thought to be cervico-facial actinomycosis, but Alternaria was identified on the culture after debridement. Simple surgical excision resulted in the complete cure without administration of systemic antifungals.
Study of the association of the known prognostic variables with EGFR expression in head and neck squamous cell carcinomas
Authors: Jadhav Toyaja , Malik Ajay , Kashif Ahmed Waheed , Shelly Divya , Mishra Prabhashankar S. , Baranwal Ajay Kumar , Sahu Rajesh 
Published: January 2024

Abstract

Context:
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most frequent malignancy in the world. Epidermal growth factor receptors (EGFRs) are members of Erb B family of receptors. EGFR is known to act as a driver of tumorigenesis in various carcinomas. Over expression of EGFR in HNSCC is associated with poor prognosis and resistance to radiotherapy. It is a useful prognostic marker, marker for response to therapy, and also a therapeutic target.

Aim:
To study the association of the known prognostic variables with EGFR expression in HNSCCs and to correlate it with the clinical outcome

Settings and Design:
Cross-sectional observational study.

Materials and Methods:
A total of 170 patients of HNSCC were evaluated for EGFR expression and followed up for at least two years, with correlation of EGFR expression with various histopathological factors and their clinical outcome.

Statistical Analysis Used:
Chi-square test.

Results:
The expression of EGFR in HNSCC in this study population was 88.82%. Statistical significance was noted between EGFR reactivity and age of the patient, its histological grade and perineural invasion. Statistical significance was also noted between EGFR reactivity and recurrence of malignancy as well as the site of recurrence.

Conclusion:
EGFR expression in patients with HNSCC is a poor prognostic biomarker and has a comparatively lower survival outcome as compared to non-EGFR expressing HNSCC cases. Hence, it will be helpful for all those patients diagnosed with HNSCC to ideally undergo an additional EGFR immunohistochemical evaluation, which, in turn, will help the oncologists in management of the tumor with anti-EGFR therapy combined with radiotherapy, to obtain a better response and a survival outcome.
Fibroblastic reticular cell tumor of eyelid: Rare case report and review of literature
Authors: Mishra Pragnya P. , Madan K , Biswas Siddhartha , Rao Anuradha Calicut Kini 
Published: January 2024

ABSTRACT
Fibroblastic reticular cell tumours (FRCT) originate from the fibroblastic reticular cells (FBRC) which are histiocytic cells, belonging to the dendritic cell family. These tumours are extremely rare, with only a few cases reported in literature. Histomorphologically, they resemble follicular dendritic cell sarcoma (FDCS); however, they differ immunophenotypically. Extranodal presentations are rare. We report a case of malignant FBRC tumour of the left eyelid, in a 23-year-old woman, who had presented with a recurrent swelling over left lower eyelid. Microscopy revealed an ill circumbscribed tumour composed of oval to spindle cells in storiform pattern, sprinkled with lymphocytes. Immunohistochemistry was performed and diagnosis of FRCT was offered. To the best of our knowledge, this is the first report of malignant FBRC tumour arising in the eyelid region. Here we present this extremely rare case with review of the available literature.
A Comparative Study of Duloxetine with Pregabalin as a Preemptive Analgesic in Lumbar Spine Surgery: A Prospective Randomized Study
Authors: Arman S. M. , Usmani Hammad , Siddiqui Obaid Ahmad , Sheikh Kulsum , Amir Syed Hussain 
Published: January 2024

Abstract

Background:
Preemptive analgesia is a method of administration of drugs prior to surgery involving blocking noxious stimuli across the perioperative period. It involves blocking the pain pathway preemptively before injury-induced hypersensitivity manifests.

Objective:
To compare the analgesic efficacy of duloxetine with pregabalin as preemptive analgesic in lumbar spine surgeries.

Design:
Randomised, double-blinded, prospective study.

Methods:
Fifty patients of both sexes between 18-55yrs undergoing elective lumbar spine surgery were randomly allocated into two groups, group P and group D of twenty-five patients each. Group P received 75 mg pregabalin once daily for three days, followed by 150 mg pregabalin daily for the next four days till the day of surgery. Group D received 20 mg duloxetine once daily for three days, followed by 40 mg duloxetine twice daily for the next four days till the day of surgery.

Outcome Measure:
Both the groups were primarily evaluated in terms of time for request of 1st rescue analgesic and total intraoperative analgesic requirement in terms of fentanyl boluses required; among other parameters.

Results:
The time for request of 1st rescue analgesic postoperatively was significantly longer in the pregabalin group (396 ± 267.77 min) than in the duloxetine group (218.4 ± 96.9 min), P = 0.003. Pregabalin recipients required considerably less rescue analgesics in terms of dosage, P = 0.006. Also, pregabalin exhibited better postoperative pain control than duloxetine as reflected by NRS comparative scores. No statistical difference was appreciated in terms of intraoperative fentanyl requirement, intraoperative hemodynamic control; nausea and sleepiness.

Conclusion:
Pregabalin is more efficacious as a preemptive analgesic than duloxetine in lumbar spine surgery.
Anomalous Great Cardiac Vein Mistaken for Left Main Coronary Artery Aneurysm in a Case of Anomalous Left Coronary Artery Arising from the Main Pulmonary Artery
Authors: Middha Rahul , Guleria Munish , Tanwar Rekha , Arora Suryansh , Bhatt Dheeraj Deo , Taneja Anil , Singh Tamanna Veer 
Published: January 2024

Abstract
Anomalous coronary venous drainage is rare and likely to be under-reported, with many cases found incidentally in cardiac imaging and autopsy studies. It may also occasionally have an important clinical implication. We report a rare case of anomalous great cardiac vein bypassing the coronary sinus to drain directly into the left brachiocephalic vein in a patient with anomalous left coronary artery arising from the main pulmonary artery. This anomalous course resulted in a misdiagnosis of coronary aneurysm on echocardiography.
Reversible Constrictive Pericarditis: Implications for Management in India
Authors: Riyaz Mirza Shohiab Ur , Devakiruba D. Nathaniel Samson , Krupa Jesu , Vimla Leena Robinson , Thomson Viji Samuel 
Published: January 2024

Abstract
Tuberculosis is the most common etiology for constrictive pericarditis in developing part of world, but a certain diagnosis may remain obscure. Reversal of constrictive physiology is possible if antitubercular therapy (ATT) and steroids are administered in early stage of disease and only few case reports are available indicating the role of ATT alone in reversing constriction.
Long-term outcomes of single-incision laparoscopic colectomy for right-sided colon cancer utilising a craniocaudal approach
Authors: Miyasaka Mamoru , Kitashiro Shuji , Takahashi Mamoru , Okawa Yuki , Sekiya Sho , Saikawa Daisuke , Teramura Koichi , Hayashi Satoshi , Suzuki Yoshinori , Matsumoto Joe , Kawada Masaya , Kawarada Yo , Kaga Kichizo , Okushiba Shunichi , Hirano Satoshi 
Published: January 2024

Abstract

Introduction:
This study aimed to evaluate the short- and long-term outcomes of single-incision laparoscopic colectomy (SILC) for right-sided colon cancer (CC) using a craniocaudal approach.

Patients and Methods:
The data of patients who underwent SILC for right-sided CC at our hospital between January 2013 and December 2022 were retrospectively collected. Surgery was performed using a craniocaudal approach. Short- and long-term operative outcomes were analysed.

Results:
In total, 269 patients (127 men, 142 women; median age 74 years) underwent SILC for right-sided CC. The cases included ileocaecal resection (n = 138) and right hemicolectomy (n = 131). The median operative time was 154 min, and the median operative blood loss was 0 ml. Twenty-seven cases (10.0%) required an additional laparoscopic trocar, and 9 (3.3%) were converted to open surgery. The Clavien–Dindo classification Grade III post-operative complications were detected in 7 (2.6%) cases. SILC was performed by 25 surgeons, including inexperienced surgeons, with a median age of 34 years. The 5-year cancer-specific survival (CSS) was 96.1% (95% confidence interval [CI] 91.3%–98.2%), and CSS per pathological disease stage was 100% for Stages 0–I and II and 86.2% (95% CI 71.3%–93.7%) for Stage III. The 5-year recurrence-free survival (RFS) was 90.6% (95% CI 85.7%–93.9%), and RFS per pathological disease stage was 100% for Stage 0–I, 91.7% (95% CI 80.5%–96.6%) for Stage II and 76.1% (95% CI 63.0%–85.1%) for Stage III.

Conclusions:
SILC for right-sided CC can be safely performed with a craniocaudal approach, with reasonable short- and long-term outcomes.
Spillage of endoscopic tattoo before laparoscopic colectomy: A case report and literature search
Authors: Baig Sarfaraz Jalil , Varma Aishwarya 
Published: January 2024

Abstract
Endoscopic tattooing with India ink is a common practice before the laparoscopic resection of polyps/tumours. Sometimes, due to inadvertent intramuscular instead of submucosal injection, it may lead to peritoneal spillage precluding the laparoscopic approach and warrant open resection. There are a few reports of post-operative abdominal sepsis. We report a case where spillage led to open conversion due to poor visibility and post-operative abdominal sepsis necessitating a change of antibiotics and prolonged hospital stay. Surgeons should be aware of these complications from this apparently innocuous step. We also did a review of the literature to see how this can be prevented and what alternative approaches have been developed.
Laparoscopic repair of iatrogenic celiac artery injury during median arcuate ligament release: A retrospection and tips at troubleshooting
Authors: Shenoy Ganesh , Thomas Marina , Ramesh B. S. 
Published: January 2024

Abstract
Median arcuate ligament (MAL) syndrome or celiac artery (CA) compression syndrome previously treated mainly by vascular surgeons using the open approach is now being increasingly performed by general surgeons with training in advanced laparoscopy. Although this approach has all the advantages of minimal access surgery, the procedure is fraught with serious complications like injury to major vascular structures during dissection. Vascular injury by far is the major cause of conversion to open procedure. Herein, we report a laparoscopic repair of iatrogenic CA injury by intra-corporeal suturing during MAL release. We also elaborate the causes, the preventive measures that can be applied to avoid such catastrophic occurrences in future. To the best of our knowledge, this is the first report of a laparoscopic repair of CA bleed during MAL release.
Laparoscopic choledochal cyst excision and biliary reconstruction in patients with previous surgery/ intervention: Feasibility and outcome
Authors: Ojha Sunita , Bharadia Lalit , Sharma Ravi , Bansal Rajiv Kumar , Chaturvedi Anupam 
Published: January 2024

Abstract

Introduction:
The aim of the study was to evaluate the feasibility and outcome of laparoscopic surgery in complicated choledochal cyst (CDC) with previous interventions (laparotomy or biliary drainage).

Patients and Methods:
Patients with CDC who underwent surgery from July 2014 to July 2019 were evaluated. CDC without previous interventions (Group A) was compared with CDC that had previous interventions (Group B) to assess the feasibility and outcome of laparoscopic surgery.

Results:
In 5 years’ period, 38 patients were operated for CDC. The mean age was similar in both groups (3.78 ± 2.27 in Group A and 4.08 ± 2.73 in Group B). Out of six CDC with previous intervention (Group B), five patients were previously managed at other institutions as follows: (1) Laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) stenting. (2) Laparotomy for biliary peritonitis and ERCP. (3) Percutaneous drainage of the large cyst. (4) Laparoscopic cholecystectomy. (5) ERCP stenting. (6) Percutaneous drainage for biliary ascites. All patients underwent laparoscopic CDC excision and hepatico-duodenostomy. The mean duration of surgery was 160.3 ± 17.22 in Group A and 169.2 ± 17.5 in Group B (P = 0.258). None required intraoperative blood transfusion. None had a bile leak. Drain was removed at 4.47 ± 0.98 in Group A, while at 4.17 ± 0.75 days in Group B (P = 0.481). There was statistically no significant difference in feed starting time or length of stay. In follow-up of 6 months–3 years, all patients are asymptomatic.

Conclusions:
Laparoscopy in complicated CDC with previous intervention is technically tedious but is feasible. The procedure is safe and delivers a good outcome.
A novel technique to identify midline during endoscopic thyroidectomy
Authors: Kataria Kamal , Garg Richa , Saini Vikram , Yadav Pritam , Preet Sehaj , Virwadia Yashwant , Nelson T 
Published: January 2024

Abstract
Endoscopic thyroidectomy is a minimally invasive surgical approach that has become popular due to its cosmetic advantages and reduced post-operative discomfort. Central to the success of this procedure is the accurate identification of the midline, which becomes a challenge in endoscopic surgeries. We propose a novel method of using methylene blue, a Food and Drug Administration-approved dye, which offers the ability to clearly mark the midline, enhancing orientation and reducing the potential for injury to critical anatomical structures. Although using methylene blue has many benefits, there are drawbacks, including the requirement for intraoperative ultrasonography. Continued research and clinical experience will be critical in improving and extending its use in the field of thyroid surgery.
Reflux Symptom and Sign Instrument: A New Instrument to Diagnose Pediatric Laryngopharyngeal Reflux
Authors: Rachmawati Elvie Zulka Kautzia , Hermani Bambang , Tamin Susyana , Hegar Badriul , Surono Agus , Harahap Alida , Kusumayati Agustin 
Published: January 2024

Abstract

Introduction:
Laryngopharyngeal reflux (LPR) is commonly found in children, usually connected to airway problems. LPR remains controversial as no standardized diagnostic instrument. Diagnostic tools available have been validated mostly in adults, i.e. Reflux Symptom Index (RSI) and reflux finding score (RFS).

Objective:
The objective of the study was to obtain a cost-effective, simple, convenient, noninvasive instrument with good diagnostic outcome.

Methods:
We compared RSI and RFS with esophageal double probe 24-h pHmetry results. A total of 29 children were recruited, aged 5–18 years. The inclusion criterion was phlegmy throat, frequent odynophagia, sensation of a lump in the throat, throat clearing, choking episodes, hoarseness, and chronic cough for at least 4 weeks. The subjects underwent nasopharyngolaryngoscopy and pHmetry insertion. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated using three scenarios.

Results:
The Reflux Symptoms-Sign Instruments (RSII), consisting of frequent throat clearing, annoying cough, choking, vocal cords abnormalities, and subglottic edema has a cutoff score of 4 and demonstrated 75% sensitivity, 77% specificity, 80% PPV, and 71% NPV.

Conclusions:
The RSII has shown a good diagnostic result in diagnosing LPR in children.
Enhanced Parent-child Interaction and Language Development during COVID-19 Quarantine in Children with Cochlear Implants
Authors: Alsari Nada A. M. , Najmaldeen Ghada T. A. 
Published: January 2024

Abstract

Objectives:
The study aimed to assess how the COVID-19 quarantine affected parent-child interaction (PCI) in children with cochlear implants (CI) and to investigate the role of parental knowledge in the early language development for these children.

Methods:
We conducted our survey primarily utilizing social media platforms such as Facebook, Twitter, and LinkedIn to recruit participants. A total of 40 parents took part in the study, with a majority being females (70%) under the age of 44 years. Most of the children with CIs (87.5%) were under the age of 10 years. Around 67.5% (n = 27) received bilateral implants, while 32.5% of children had unilateral CI The parents filled out a questionnaire which had five domains, and responses related to demographic information, PCI, and the child’s communication skills were recorded.

Results:
Our statistical analysis, using paired t-tests, revealed a significant and positive impact of the quarantine period on both PCI (P = 0.001, t = 6.50) and the communication skills of the children (P = 0.001, t = 3.77). A simple linear regression analysis indicated that parental knowledge did not significantly affect PCI (R
2 = 0.003; P = 0.73). PCI accounted for 14% of the variation in children’s communication skills (P = 0.01).

Conclusions:
In conclusion, our study sheds a light on the impact of the COVID-19 quarantine on the quality of PCI in children with CIs. The findings underscore the resilience and adaptability of both parents and children facing challenging circumstances. Notably, the increased quality and duration of time spent together allowed for enhanced PCI and subsequently led to improvements in the communication skills of the children.
High-intensity aerobic exercise training improves exercise capacity, dyspnea, and fatigue in patients with severe asthma using triple inhaler
Authors: Jao Lun-Yu , Hsieh Po-Chun , Wu Yao-Kuang , Tzeng I-Shiang , Yang Mei-Chen , Su Wen-Lin , Lan Chou-Chin 
Published: January 2024

Objectives:
Asthma is a chronic respiratory disease that affects millions of people worldwide and causes severe symptoms such as wheezing, coughing, and breathing difficulty. Despite modern treatments, 3%–10% of patients develop severe asthma, which requires high-dose medications, and they may still experience frequent and severe symptoms, exacerbations, and psychological impacts. This study aimed to investigate the effects of high-intensity aerobic exercise training (HIAET) in patients with severe asthma.

Materials and Methods:
Patients with severe asthma were recruited, and cardiopulmonary exercise tests, dyspnea, and leg fatigue scores were performed before HIAET. Participants underwent a 12-week hospital-based HIAET, which involved exercising twice weekly to reach 80% of their peak oxygen uptake (VO2).

Results:
Eighteen patients with severe asthma underwent HIAET, which resulted in significant improvement in peak VO2 (1214.0 ± 297.9–1349.4 ± 311.2 mL/min, P = 0.004) and work rate (80.6 ± 21.2–96.2 ± 24.8 watt, P < 0.001) and decrease in dyspnea (5.1 ± 1.8–4.1 ± 1.2, P = 0.017) and fatigue scores (5.2 ± 2.3–4.0 ± 1.2, P = 0.020) at peak exercise. No significant changes were observed in spirometry results, respiratory muscle strength, or circulatory parameters.

Conclusion:
HIAET can lead to improved exercise capacity and reduced dyspnea and fatigue scores at peak exercise without changes in spirometry, respiratory muscle strength, and circulatory parameters.
Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome
Authors: Chen Jie , Zhang Wan-Chao , Tang Xiao-Qiang , Yin Ruo-Han , Wang Tao , Wei Xiao-Yu , Pan Chang-Jie 
Published: January 2024

BACKGROUND
Cardiovascular disease is a major complication of diabetes mellitus (DM). Type-2 DM (T2DM) is associated with an increased risk of cardiovascular events and mortality, while serum biomarkers may facilitate the prediction of these outcomes. Early differential diagnosis of T2DM complicated with acute coronary syndrome (ACS) plays an important role in controlling disease progression and improving safety.
AIM
To investigate the correlation of serum bilirubin and γ-glutamyltranspeptidase (γ-GGT) with major adverse cardiovascular events (MACEs) in T2DM patients with ACS.
METHODS
The clinical data of inpatients from January 2022 to December 2022 were analyzed retrospectively. According to different conditions, they were divided into the T2DM complicated with ACS group (T2DM + ACS, n = 96), simple T2DM group (T2DM, n = 85), and simple ACS group (ACS, n = 90). The clinical data and laboratory indices were compared among the three groups, and the correlations of serum total bilirubin (TBIL) levels and serum γ-GGT levels with other indices were discussed. T2DM + ACS patients received a 90-day follow-up after discharge and were divided into event (n = 15) and nonevent (n = 81) groups according to the occurrence of MACEs; Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in patients.
RESULTS
The T2DM + ACS group showed higher γ-GGT, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin (HbA1c) and lower TBIL and high-density lipoprotein cholesterol levels than the T2DM and ACS groups (P < 0.05). Based on univariate analysis, the event and nonevent groups were significantly different in age (t = 3.3612, P = 0.0011), TBIL level (t = 3.0742, P = 0.0028), γ-GGT level (t = 2.6887, P = 0.0085), LDL-C level (t = 2.0816, P = 0.0401), HbA1c level (t = 2.7862, P = 0.0065) and left ventricular ejection fraction (LEVF) levels (t=3.2047, P = 0.0018). Multivariate logistic regression analysis further identified that TBIL level and LEVF level were protective factor for MACEs, and age and γ-GGT level were risk factors (P < 0.05).
CONCLUSION
Serum TBIL levels are decreased and γ-GGT levels are increased in T2DM + ACS patients, and the two indices are significantly negatively correlated. TBIL and γ-GGT are independent influencing factors for MACEs in such patients.
Effect of Student Perception on Teaching and Learning Mathematics in Secondary Schools in El’arish in North Sinai Governorate in Egypt
Authors: BYIRINGIRO Emmanuel 
Published: January 2024

Purpose: The aim of this paper was to investigate the effect of students ‘perception on teaching and learning Mathematics students in public Schools in El’arish in North Sinai Governorate in Egypt. The hypothesis of the study was formulated and tested to guide the study.
Methodology: The survey research design type was adopted and the targeted population of one hundred and ninety-nine (119) respondents composed by 5 principals, 16 mathematic teachers and 98 students from senior secondary schools, were sampled by using stratified sampling and sample random sampling techniques. The collected data was analyzed using descriptive statistics, correlation, and regression analysis through the statistical package for social science (SPSS) version 21. The data collected were analysed using descriptive statistics and multiple regression.
Findings: The results of the findings indicated that the students’ perception was more correlated with teaching and learning Mathematics (r = 0.822; p= 0.000). Multiple linear regression analysis showed that students ‘perception contributed to 70.2% of variation on the performance, hence plays a vital role in teaching and learning Mathematics students in secondary schools in El Arish in North Sinai Governorate in Egypt. Additionally, the relationship between perception and students Mathematics performance in the study was very strong.
Unique Contribution to Theory, Practice and Policy: The study recommended that Mathematics teacher should be diverse in their use of methodology which can as well help their student in their own area of learning mathematics.