bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involving patients in drug development for Neglected Tropical Diseases (NTDs): A qualitative study exploring and incorporating preferences of patients with cutaneous leishmaniasis into Target Product Profile development
Authors: Castro María del Mar , Erber Astrid C. , Arana Byron , Cota Gláucia , Denkinger Claudia M. , Harrison Nicole , Kutyi Julia , López-Carvajal Liliana , Plugge Emma , Walochnik Julia , Olliaro Piero 
Published: February 2024

BackgroundTarget Product Profiles (TPPs) are instrumental to help optimise the design and development of therapeutics, vaccines, and diagnostics – these products, in order to achieve the intended impact, should be aligned with users’ preferences and needs. However, patients are rarely involved as key stakeholders in building a TPP.MethodologyThirty-three cutaneous leishmaniasis (CL) patients from Brazil, Colombia, and Austria, infected with New-WorldLeishmaniaspecies, were recruited using a maximum variation approach along geographic, sociodemographic and clinical criteria. Semi-structured interviews were conducted in the respective patient’s mother tongue. Transcripts, translated into English, were analysed using a framework approach. We matched disease experiences, preferences, and expectations of CL patients to a TPP developed by DNDi(Drug for Neglected Diseasesinitiative) for CL treatment.Principal findingsPatients’ preferences regarding treatments ranged from specific efficacy and safety endpoints to direct and significant indirect costs. Respondents expressed views about trade-offs between efficacy and experienced discomfort/adverse events caused by treatment. Reasons for non-compliance, such as adverse events or geographical and availability barriers, were discussed. Considerations related to accessibility and affordability were relevant from the patients’ perspective.Conclusions/SignificanceNTDs affect disadvantaged populations, often with little access to health systems. Engaging patients in designing adapted therapies could significantly contribute to the suitability of an intervention to a specific context and to compliance, by tailoring the product to the end-users’ needs. This exploratory study identified preferences in a broad international patient spectrum. It provides methodological guidance on how patients can be meaningfully involved as stakeholders in the construction of a TPP of therapeutics for NTDs. CL is used as an exemplar, but the approach can be adapted for other NTDs.
Association of multi-phase rates of force development during an isometric leg press with vertical jump performances
Authors: Zushi Kodayu , Kariyama Yasushi , Nagahara Ryu , Yoshida Takuya , Zushi Amane , Ohyama-Byun Keigo , Ogata Mitsugi 
Published: February 2024

Purpose
This study aimed to elucidate characteristics of explosive force-production capabilities represented by multi-phase rate of force developments (IRFDs) during isometric single-leg press (ISLP) through investigating relationships with countermovement (CMJ) and rebound continuous jump (RJ) performances.

Methods
Two-hundred-and-thirty male athletes performed ISLP, CMJ with an arm swing (CMJAS), and RJ with an arm swing (RJAS). IRFDs were measured during ISLP using a custom-built dynamometer, while CMJAS and RJAS were measured on force platforms. The IRFDs were obtained as rates of increase in force across 50 ms in the interval from the onset to 250 ms. Jump height (JH) was obtained from CMJAS, while RJAS provided JH, contact time (CT), and reactive strength index (RSI) values.

Results
All IRFDs were correlated with CMJAS-JH (ρ = 0.20–0.45, p ≤ 0.003), RJAS-JH (ρ = 0.22–0.46, p ≤ 0.001), RJAS-RSI (ρ = 0.29–0.48, p < 0.001) and RJAS-CT (ρ = −0.29 to −0.25, p ≤ 0.025). When an influence of peak force was considered using partial rank correlation analysis, IRFDs during onset to 150 ms were correlated with CMJAS-JH (ρxy/z = 0.19–0.36, p ≤ 0.004), IRFDs during onset to 100 ms were correlated with RJAS-JH and RJAS-RSI (ρxy/z = 0.33–0.36, p < 0.001), and IRFD during onset to 50 ms was only correlated with RJAS-CT (ρxy/z = −0.23, p < 0.001).

Conclusion
The early phase (onset to 150 ms) IRFDs measured using ISLP enabled the assessment of multiple aspects of leg-extension strength characteristics that differ from maximal strength; these insights might be useful in the assessment of the athletes’ leg-extension strength capabilities.
Dealing with the diagnosis of Parkinson’s disease and its implications for couple functioning in the early stage: An interpretative phenomenological analysis
Authors: Wawrziczny Emilie , Flinois Bérengère , Constant Emilie , Brugallé Elodie , Sokolowski Céline , Manceau Charlotte , Baille Guillaume , Defebvre Luc , Dujardin Kathy , Antoine Pascal 
Published: February 2024

Background
For couples facing Parkinson’s disease, marital relationships are significantly impacted, even at the early stages of the disease. However, very few studies have explicitly explored the functioning of the couple and how both partners deal with Parkinson’s disease. The aim of this study was to explore the experiences and strategies of couples facing Parkinson’s disease in the early stage using dyadic interpretative phenomenological analysis.

Methods
Fifteen couples agreed to participate in the study. Semistructured interviews were conducted with each partner separately regarding his or her individual experience with Parkinson’s disease, the couple’s history, the impact of the diagnosis on the functioning of the couple, and his or her projections for the future.

Results
Three higher-order themes emerged from the analyses. The first theme, "Being tested by the diagnosis", highlights 4 dyadic configurations according to the individual’s and the couple’s capacity for adjustment following the diagnosis: "noncongruent", "collapsed", "relieved" and "avoidant". The second theme, "Talking about everything except the disease", underlines that communication about the disease is often avoided both within the couple and with relatives to protect the persons with Parkinson’s disease or respect their wishes. The third theme, "Supporting each other", describes the different levels of harmony between the two partners in the management of daily life and symptoms and their relational impacts.

Conclusion
These results allow us to better understand the experiences of both partners and to highlight the importance of promoting better acceptance of the diagnosis by persons with Parkinson’s disease to allow better communication between partners and with relatives. Such support prevents disease-specific distress and facilitates better adjustment in the later stages of the disease.
The level of antiretroviral therapy (ART) adherence among orphan children and adolescents living with HIV/AIDS: A systematic review and meta-analysis
Authors: Kamau Stanley Githaiga , Akatusasira Rita , Namatovu Angella , Kibet Emmanuel , Ssekitto Joseph Mayanja , Mamun Mohammed A. , Kaggwa Mark Mohan 
Published: February 2024

Background
Many children and adolescents living with HIV have ended up as orphans. Due to HIV taking away their parents leaves them deprived of their most important social network and support, which predisposes them to poor adherence to antiretroviral therapy (ART). Various studies have shown poor adherence to ART among orphaned children and adolescents. This systematic review and meta-analysis, therefore, aims to determine the level of ART adherence among orphaned children and adolescents living with HIV/AIDS.

Methods
This PROSPERO registered review (CRD42022352867) included studies from PubMed, Google Scholar, Scopus, Web of Science, Africa Journal Online, and selected HIV/AIDS journals from data inception to June 01, 2022. We included articles published in all languages that report the prevalence of adherence to ART among children and adolescent orphans (single parent orphans and/or double orphans) living with HIV/AIDS. We excluded qualitative studies, case studies, opinion papers, and letters to editors. We used the random-effect model to calculate the pooled prevalence of ART adherence based on the highest prevalence provided by the various methods in a particular study. We used the Joanna Briggs Institute Appraisal tool for the prevalence study to evaluate for risk of bias in the included studies. The Egger’s test was used to assess small study effects.

Results
Out of 1087 publications identified from the various databases, six met the selection criteria. The included six studies had a total 2013 orphans living with HIV/AIDS. The pooled prevalence of ART adherence was 78∙0% (95% Confidence Interval: 67.4–87.7; I2 = 82.92%, p<0∙001) and ranged between 7∙6% and >95%, using one of the following methods: pill count, caregiver’s self-report, clinical attendance, and nevirapine plasma levels (above three μg/mL). The factors associated with adherence were pill burden, caregiver involvement, stunting, and caregiver relationship.

Limitation
There was a high level of heterogeneity in the finding.

Conclusion
Approximately four fifth of orphan children and adolescents living with HIV/AIDS adhere to ART. Strategies to improve adherence among this group should be prioritized, especially among the double orphaned children and adolescents.
Loneliness and fearfulness are associated with non-fatal drug overdose among people who inject drugs
Authors: Falade-Nwulia Oluwaseun , Ward Kathleen , Wagner Karla D. , Karimi-Sari Hamidreza , Hsu Jeffrey , Sulkowski Mark , Latkin Carl , Nwulia Evaristus 
Published: February 2024

Background
People who inject drugs (PWID) experience high rates of drug overdose death with the risk of mortality increasing after each non-fatal event. Racial differences exist in drug overdose rates, with higher rates among Black people who use drugs. Psychological factors may predict drug overdose.

Methods
Cross-sectional data from a survey administered to PWID in Baltimore, MD enrolled in a social network-based intervention were analyzed. Linear regression methods with generalized estimating equations were used to analyze data from indexes and network members to assess for psychological factors significantly associated with self-reported number of lifetime drug overdoses. Factors associated with number of overdoses were assessed separately by race.

Results
Among 111 PWID enrolled between January 2018 and January 2019, 25.2% were female, 65.7% were Black, 98.2% reported use of substances in addition to opioids, and the mean age was 49.0 ± 8.3 years. Seventy-five individuals (67.6%) had a history of any overdose with a mean of 5.0 ± 9.7 lifetime overdoses reported. Reports of feeling fearful (β = 9.74, P = 0.001) or feeling lonely all of the time (β = 5.62, P = 0.033) were independently associated with number of drug overdoses. In analyses disaggregated by race, only the most severe degree of fearfulness or loneliness was associated with overdose among Black participants, whereas among White participants, any degree of fearfulness or loneliness was associated with overdose.

Conclusions
In this study of PWID loneliness and fearfulness were significantly related to the number of reported overdose events. These factors could be targeted in future interventions.
Association of cesarean section and infectious outcomes among infants at 1 year of age: Logistic regression analysis using data of 104,065 records from the Japan Environment and Children’s Study
Authors: Maeda Hajime , Hashimoto Koichi , Iwasa Hajime , Kyozuka Hyo , Kume Yohei , Go Hayato , Sato Akiko , Ogata Yuka , Murata Tsuyoshi , Fujimori Keiya , Shinoki Kosei , Nishigori Hidekazu , Yasumura Seiji , Hosoya Mitsuaki ,   the Japan Environment and Children’s Study (JECS) Group
Published: February 2024

Background
There has been a recent decrease in the prevalence of infectious diseases in children worldwide due to the usage of vaccines. However, the association between cesarean delivery and infectious diseases remains unclear. Here, we aimed to clarify the association between cesarean delivery and the development of infectious diseases.

Methods
This study is a cross-sectional study. We used data from the Japan Environment and Children’s Study, which is a prospective, nationwide, government-funded birth cohort study. The data of 104,065 records were included. Information about the mode of delivery, central nervous system infection (CNSI), otitis media (OM), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), gastrointestinal infection (GI), and urinary tract infection (UTI) was obtained from questionnaires and medical records transcripts. Multiple logistic regression analysis was used to assess the association between cesarean delivery and CNSI, OM, URTI, LRTI, GI, and UTI risk.

Results
We included a total of 74,477 subjects in this study, of which 18.4% underwent cesarean deliveries. After adjusting for the perinatal, socioeconomic, and postnatal confounding factors, children born by cesarean delivery did not have an increased risk of developing CNSI (95% confidence interval [CI] 0.46–1.35), OM (95% CI 0.99–1.12), URTI (95% CI 0.97–1.06), LRTI (95% CI 0.98–1.15), GI (95% CI 0.98–1.11), or UTI (95% CI 0.95–1.45).

Conclusions
This nationwide cohort study did not find an association between cesarean delivery and CNSI, OM, URTI, LRTI, GI, and UTI. However, further studies are needed to evaluate the role of cesarean delivery in the development of infectious diseases.
The use of biologic therapy in patients with ankylosing spondylitis and coxitis: dynamics of clinical and laboratory parameters and structural progression
Authors: Erdes Sh. F. , Achikyan V. F. , Agafonova E. M. 
Published: February 2024

Hip joint inflammation (coxitis) occurs in almost half of patients with ankylosing spondylitis (AS) and often leads to early disability. A therapy for this condition has not yet been developed, although it is one of the indications for the initiation of biologic therapy in national recommendations. The review presents data from recent clinical trials on the use of biologics, focusing on the Russian national multicenter study of GO-COX in patients with AS with coxitis.Tumour necrosis factor-α inhibitors have been shown to be effective against inflammatory affection of the hip joint in patients with AS, and their administration over a two-year period inhibits the progression of coxitis.
Peculiarities of pharmacotherapy of patients with rheumatoid arthritis associated with interstitial lung disease
Authors: Gordeev A. V. , Galushko E. A. , Matyanova E. V. , Pozhidaev E. V. , Zotkin E. G. , Lila A. M. 
Published: February 2024

Objective: a comparative study of the peculiarities of pharmacotherapy of rheumatoid arthritis (RA) in presence and in absence of interstitial lung disease (ILD).Material and methods. The study included 1034 patients with active RA who met the 2010 ACR/EULAR criteria. Patients were divided into two groups: with ILD according to high-resolution computed tomography of the lungs (n=82) and without ILD or other types of chronic obstructive pulmonary diseases, including bronchial asthma (52 patients excluded; n=900). Based on medical documentation, archived medical records and medical history, a “drug card” was created for all stages of pharmacotherapy of patients with active RA. The Cumulative Illness Index Score (CIRS) was used to assess the profile and severity of comorbidities.Results and discussion. The main indicators of RA activity in the patients of the two groups were comparable, but a greater number of comorbidities (p˂0.0001) and a higher value of the CIRS multimorbidity index (p˂0.0001) were found in the group with ILD. The presence of ILD had no influence on the frequency of prescription, the total duration of use and the maximum dose of glucocorticoids (GC) (p˂0.05). The average dose of GC was statistically significantly higher in the group with ILD (p=0.008). These patients were taking disease-modifying antirheumatic drugs (DMARDs): methotrexate (p=0.04), leflunomide (p=0.02) and sulfasalazine (p=0.03), less frequently, but they took hydroxychloroquine significantly more frequently (p=0.02) with a comparable total duration of use of each medication. RA patients with ILD and without ILD received biologic DMARDs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) in 62.2 and 59.6% of cases, respectively (p˂0.05). At the same time, patients without ILD had experience of taking a greater number of different bDMARDs/tsDMARDs (p=0.03). In the group with ILD, patients more frequently received anti-B-cell therapy (p˂0.0001) and significantly less frequently drugs of other classes: tumour necrosis factor α inhibitors (p˂0.0001) and interleukin 6 inhibitors (p=0.01), T-cell costimulation blocker (p=0.04) and Janus kinase inhibitors (p=0.001). Patients with ILD were statistically significantly older at the start of bDMARD/tsDMARD therapy (p˂0.0001), and the period from the onset of RA to the start of bDMARD/tsDMARD therapy was comparable in both groups (p˂0.05).Conclusion. The observed peculiarities of pharmacotherapy in the group with ILD (frequency of use, choice and dose of GC, DMARDs, biologics and tsDMARDs) are probably related to the presence of ILD on the one hand and to the characteristics of concomitant pathology and older age on the other, as the activity of RA was comparable in our patients with and without ILD.
Statistical models for assessing agreement for quantitative data with heterogeneous random raters and replicate measurements
Authors: Ekstrøm Claus Thorn , Carstensen Bendix 
Published: February 2024

Abstract
Agreement between methods for quantitative measurements are typically assessed by computing limits of agreement between pairs of methods and/or by illustration through Bland–Altman plots. We consider the situation where the observed measurement methods are considered a random sample from a population of possible methods, and discuss how the underlying linear mixed effects model can be extended to this situation. This is relevant when, for example, the methods represent raters/judges that are used to score specific individuals or items. In the case of random methods, we are not interested in estimates pertaining to the specific methods, but are instead interested in quantifying the variation between the methods actually involved making measurements, and accommodating this as an extra source of variation when generalizing to the clinical performance of a method. In the model we allow raters to have individual precision/skill and permit linked replicates (i.e., when the numbering, labeling or ordering of the replicates within items is important). Applications involving estimation of the limits of agreement for two datasets are shown: A dataset of spatial perception among a group of students as well as a dataset on consumer preference of French chocolate. The models are implemented in the MethComp package for R [Carstensen B, Gurrin L, Ekstrøm CT, Figurski M. MethComp: functions for analysis of agreement in method comparison studies; 2013. R package version 1.22, R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2012].
Coherent transient exciton transport in disordered polaritonic wires
Authors: Aroeira Gustavo J. R. , Kairys Kyle T. , Ribeiro Raphael F. 
Published: February 2024

Abstract
Excitation energy transport can be significantly enhanced by strong light–matter interactions. In the present work, we explore intriguing features of coherent transient exciton wave packet dynamics on a lossless disordered polaritonic wire. Our main results can be understood in terms of the effective exciton group velocity, a new quantity we obtain from the polariton dispersion. Under weak and moderate disorder, we find that the early wave packet spread velocity is controlled by the overlap of the initial exciton momentum distribution and its effective group velocity. Conversely, when disorder is stronger, the initial state is nearly irrelevant, and red-shifted cavities support excitons with greater mobility. Our findings provide guiding principles for optimizing ultrafast coherent exciton transport based on the magnitude of disorder and the polariton dispersion. The presented perspectives may be valuable for understanding and designing new polaritonic platforms for enhanced exciton energy transport.
Metasurface for programmable quantum algorithms with classical and quantum light
Authors: Tanuwijaya Randy Stefan , Liang Hong , Xi Jiawei , Wong Wai Chun , Yung Tsz Kit , Tam Wing Yim , Li Jensen 
Published: February 2024

Abstract
Metasurfaces have recently opened up applications in the quantum regime, including quantum tomography and the generation of quantum entangled states. With their capability to store a vast amount of information by utilizing the various geometric degrees of freedom of nanostructures, metasurfaces are expected to be useful for processing quantum information. Here, we propose and experimentally demonstrate a programmable metasurface capable of performing quantum algorithms using both classical and quantum light with single photons. Our approach encodes multiple programmable quantum algorithms and operations, such as Grover’s search algorithm and the quantum Fourier transform, onto the same metalens array on a metasurface. A spatial light modulator selectively excites different sets of metalenses to carry out the quantum algorithms, while the interference patterns captured by a single-photon camera are used to extract information about the output state at the selected output directions. Our programmable quantum metasurface approach holds promising potential as a cost-effective means of miniaturizing components for quantum computing and information processing.
Temporally deuterogenic plasmonic vortices
Authors: Yuan Xinyao , Xu Quan , Lang Yuanhao , Yao Zhibo , Jiang Xiaohan , Li Yanfeng , Zhang Xueqian , Han Jiaguang , Zhang Weili 
Published: February 2024

Abstract
Over the past decade, orbital angular momentum has garnered considerable interest in the field of plasmonics owing to the emergence of surface-confined vortices, known as plasmonic vortices. Significant progress has been made in the generation and manipulation of plasmonic vortices, which broadly unveil the natures of plasmonic spin–orbit coupling and provide accessible means for light–matter interactions. However, traditional characterizations in the frequency domain miss some detailed information on the plasmonic vortex evolution process. Herein, an exotic spin–orbit coupling phenomenon is demonstrated. More specifically, we theoretically investigated and experimentally verified a temporally deuterogenic vortex mode, which can be observed only in the time domain and interferes destructively in the intensity field. The spatiotemporal evolution of this concomitant vortex can be tailored with different designs and incident beams. This work extends the fundamental understanding of plasmonic spin–orbit coupling and provides a unique optical force manipulation strategy, which may fuel plasmonic research and applications in the near future.