bluuebunny/crossref_metadata_2025_split huggingface dataset:
How oral health care organizations formulate actionable statements to inform practice and policy: A protocol for a systematic survey
Authors: Verdugo-Paiva Francisca , Bonfill Cosp Xavier , Alonso-Coello Pablo , Ávila-Oliver Camila , Glick Michael , Carrasco-Labra Alonso 
Published: October 2023

Background: Oral diseases are a major global public health problem that impacts the quality of life of those affected. While widespread consensus exists on the importance of high-quality, evidence-informed guidelines to inform practice and public health decisions in medicine, appropriate methodologies and standards are not commonly adhered to among producers of oral health guidelines. This systematic survey aims to identify organizations developing evidence-informed guidelines and policy documents in oral health globally, and describe the methods and processes used. Methods: We will conduct manual searches on the websites of guideline developers, Ministries of Health, and scientific societies. Additionally, we will systematically search electronic databases to identify published guidelines and collect the name of the responsible entity. We will include organizations that regularly develop guidelines on any oral health topic and that explicitly declare the inclusion of research evidence in its development process. Subsequently, we will use a standardized form to extract data about the characteristics of the organization, the characteristics of their guideline or policy documents, and their formal recommendation development processes. These data will be extracted from various sources, such as the organization's official website, the methods section of each guideline, or methodological handbooks. We will use descriptive statistics to analyze the extracted data. Discussion: This systematic survey will synthesize key characteristics and methodologies used by organizations developing evidence-informed guidelines. This study will provide the basis for future development of a sustainable and connected collaborative network for evidence-informed guidelines and policy documents in oral health globally. The results will be disseminated through peer-reviewed publications, conference presentations, and targeted dissemination of findings with the identified organizations. Our systematic survey represents a necessary first step toward improving the field of oral health policies and guidelines.
Brain Tumour Related Headache: Features, Pathophysiology and Management Strategies
Authors: Doruch Patrycja , Senger Michał , Rogacka-Pyrak Karolina , Kędziora-Kornatowska Kornelia 
Published: October 2023

Introduction. Brain tumours constitute approximately 1% of all newly diagnosed cancers. Their manifestation typically involves headache, neurological impairment, focal onset seizures and syndromes related to tumour location. Severe headache presents as a prevailing symptom and occurs in over 50% of patients. Brain tumour associated headache exerts significant effect on quality of life in cancer patients. The following article aims to provide a comprehensive overview of most common and promising brain tumour related headache treatment strategies.
State of knowledge. Headache in brain tumour patients arises from traction or displacement of intracranial pain-sensitive structures, such as vascular tissue, dura mater or periosteum. This can be caused by tumour’s mass itself, by tumour associated oedema or as a sequela of anti-tumour treatment. Most common therapeutic modalities include tumour surgical resection, cerebral oedema management, radiotherapeutic interventions and administration of analgesic agents. Complete removal of the tumour stands as the most effective approach, often bringing substantial alleviation in majority of cases.
Conclusion. Headache affects the majority of individuals afflicted by brain tumours. Not all patients are suitable candidates for the resection of the underlying neoplasm. In such instances, the application of alternative approaches might be beneficial. Ongoing and future investigations may enhance the development of novel treatment strategies, possibly influencing the well-being of cancer patients, especially within palliative care area.
Current innovative treatments of obesity
Authors: Wach Damian , Głaz Aneta , Wiśniewska Jolanta , Radziejowska Zuzanna 
Published: October 2023

Obesity is a complex and pervasive chronic health concern with multifaceted origins in which abnormal or excessive fat accumulation worsens health, increases the risk of long-term medical complications and shortens life expectancy. It is associated with type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. More than 603.7 million adults are estimated to be obese. The cause of obesity is a long-term energy imbalance caused by a combination of increased energy intake and decreased energy expenditure.
The purpose of this study is to analyze the effectiveness of modern obesity treatments such as intermittent fasting, semaglutide and surgical interventions. Intermittent fasting involves voluntary periods of restricted or zero caloric intake at specified intervals. However, research results on the effectiveness of this dietary strategy are conflicting. The findings indicate that incorporating physical exercise can further enhance the outcomes of applying this diet. Semaglutide, a GLP-1 (glucagon-like peptide-1) analog, has shown efficacy in promoting weight loss among adults and adolescents, along with metabolic and cardiovascular improvements. Laparoscopic sleeve gastrectomy (LSG) is a common bariatric procedure, while Roux-en-Y gastric bypass (LRYGB) is another option. Long-term studies show that both methods effectively promote weight loss.
In conclusion, obesity is a multifaceted condition that requires a comprehensive treatment approach. Individualized strategies including dietary changes, pharmaceutical interventions such as semaglutide, and surgical options can together contribute to effective weight management and improved health outcomes.
Algorithm Aversion: Evidence from Ridesharing Drivers
Authors: Liu Meng , Tang Xiaocheng , Xia Siyuan , Zhang Shuo , Zhu Yuting , Meng Qianying 
Published: October 2023

The low rate of adoption by human users often hinders AI algorithms from achieving their intended efficiency gains. This is particularly true for algorithms that prioritize system-wide objectives because they can create misalignment of incentives and cause confusion among potential users. We provide one of the first large-scale field studies on algorithm aversion by leveraging an algorithmic recommendation rollout on a large ridesharing platform. We identify contextual experience and herding as two important factors that explain ridesharing drivers’ aversion to an algorithm that is designed to help drivers make better location choices. Specifically, we find that drivers are less likely to follow the algorithm when the algorithmic recommendation does not align with their past experience at a given location-time unit and when their peers’ actions contradict the algorithmic recommendations. We discuss the managerial implications of these findings. This paper was accepted by Catherine Tucker, Special Issue on The Human-Algorithm Connection. Funding: The research at Shanghai Jiaotong University was supported by the National Natural Science Foundation of China [Grants 72202135, 72110107001, 72231003]. S. Zhang acknowledges the support of Shanghai Pujiang Program [Grant 21PJC070], and Special Fund for Creative Research Groups [Grant 72221001]. Y. Zhu acknowledges the support of National University of Singapore [Grant WBS A-8000489-00-00]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.02475 .
The Complexity of Pacing for Second-Price Auctions
Authors: Chen Xi , Kroer Christian , Kumar Rachitesh 
Published: October 2023

Budget constraints are ubiquitous in online advertisement auctions. To manage these constraints and smooth out the expenditure across auctions, the bidders (or the platform on behalf of them) often employ pacing: each bidder is assigned a pacing multiplier between zero and one, and her bid on each item is multiplicatively scaled down by the pacing multiplier. This naturally gives rise to a game in which each bidder strategically selects a multiplier. The appropriate notion of equilibrium in this game is known as a pacing equilibrium. In this work, we show that the problem of finding an approximate pacing equilibrium is PPAD-complete for second-price auctions. This resolves an open question of Conitzer et al. [Conitzer V, Kroer C, Sodomka E, Stier-Moses NE (2022a) Multiplicative pacing equilibria in auction markets. Oper. Res. 70(2):963–989]. As a consequence of our hardness result, we show that the tâtonnement-style budget-management dynamics introduced by Borgs et al. [Borgs C, Chayes J, Immorlica N, Jain K, Etesami O, Mahdian M (2007) Dynamics of bid optimization in online advertisement auctions. Proc. 16th Internat. Conf. World Wide Web (ACM, New York), 531–540] are unlikely to converge efficiently for repeated second-price auctions. This disproves a conjecture by Borgs et al. [Borgs C, Chayes J, Immorlica N, Jain K, Etesami O, Mahdian M (2007) Dynamics of bid optimization in online advertisement auctions. Proc. 16th Internat. Conf. World Wide Web (ACM, New York), 531–540], under the assumption that the complexity class PPAD is not equal to P. Our hardness result also implies the existence of a refinement of supply-aware market equilibria which is hard to compute with simple linear utilities. Funding: This work was supported by National Science Foundation (CCF-1703925, IIS-1838154).
DAYA HASIL DAN KANDUNGAN ANTOSIANIN GENOTIP UBI JALAR UNGU (PURPLE-FLESHED SWEET POTATO) DI JATINANGOR, JAWA BARAT
Authors: Noerrizki Amalia Murnihati , Prayudha Harlino Nandha , Ustari Debby , Suganda Tarkus , Concibido Vergel , Karuniawan Agung 
Published: October 2023

Daya hasil adalah kemampuan tanaman untuk memproduksi hasil sesuai dengan potensinya. Ubi jalar ungu mengandung senyawa antosianin yang merupakan senyawa yang dapat dimanfaatkan untuk berbagai produk karena memberikan efek yang baik untuk kesehatan. Tujuan penelitian ini adalah untuk mengestimasi daya hasil dan kandungan antosianin pada 12 genotip ubi jalar ungu. Penelitian lapangan dilakukan menggunakan Rancangan Acak Kelompok (RAK) dengan 3 kali ulangan. Pengamatan dilakukan terhadap karakter bentuk ubi, warna daging ubi, warna kulit, panjang ubi, diameter ubi, jumlah ubi dan bobot ubi per plot berdasarkan Descriptors for Sweet Potato (Huaman, 1999). Kandungan antosianin dievaluasi dengan metode pH Differential sedangkan variabel warna ekstrak dianalisis berdasarkan nilai L*, a*, b*. Hasil menunjukkan terdapat keragaman pada bentuk ubi, panjang ubi, diameter ubi, jumlah ubi dan bobot ubi per plot. Bentuk ubi bervariasi yaitu oval memanjang, elips membulat, elips, obovate, berlengkung. 11 genotip ubi jalar ungu memiliki warna daging berpigmen dengan antosianin dan warna kulit yaitu ungu. Hasil analisis LSI menunjukkan PF 4, PF 5, PF 6, PF 7, PF 8, PF 9 dan PF 12 memiliki penampilan lebih baik dari varietas pembanding. Kandungan antosianin tertinggi yaitu PF 12 (84,02 mg/100g). Analisis korelasi menunjukkan antosianin memiliki korelasi positif dengan karakter hasil dan nilai a*.
Growth Evaluation of Red Tilapia (Oreochromis spp) Under Different Cycles of Fasting And Re-Feeding
Authors: Robisalmi Adam 
Published: October 2023

Feed restriction through fasting is a widely recommended feed management strategy in aquaculture, where this strategy is believed to have a positive effect on fish growth performance. This study aims to evaluate the growth performance of red tilapia in various cycles of fasting and re-feeding. The activity was carried out at Research Institute Fish Breeding from August to November 2020 . The research method used was experimental with 5 treatments with 4 replications, namely control (fish were fed daily), then the fasting treatment was S7 (7 days of fasting), S14 (14 days of fasting), S21 (21 days of fasting) and S28 (28 fasting day) followed by refeeding until the end of maintenance. Maintenance was carried out for 90 days in a concrete tub measuring 2x1m3 with a stocking density of 28 fishes / unit. During the rearing period the fish were fed satiation three times a day. The results showed that there was a decrease in growth along with the increase of the fasting period, but there was a trend of increasing growth after re-feeding with over compensatory growth in treatment S7 and partial compensatory growth in treatments S14 and S21. Likewise, the value of the condition factor and the hepatosomatic index during the fasting period decreased, but after feeding, the values were not different from those of fish fed continuously.
Nanoparticles in Enhancing Mechanical Properties of Silicone for Maxillofacial Rehabilitation - A Review
Authors: Shahad Fadhil Bunyan  , Fatanah Mohamad Suhaimi  , Faraedon Mohidden Mostafa Zardawi  , Siti Noor Fazliah Mohd Noor  , Muhammad Azrul Zabidi  
Published: October 2023

BACKGROUND
Facial prostheses are made to restore a missing part of the face, so they must be made from a material that mimics the surrounding soft tissues and skin in properties. The studies nowadays show that the maxillofacial silicone elastomer is widely used for this purpose because of its biocompatibility, can be easily colored by intrinsic or extrinsic coloration, and good elasticity. The drop points of the pure silicone elastomers are the mechanical properties such as the tear strength and the tensile strength, which need to be improved to be clinically applicable. This improvement may be done by the addition of some types of Nano-oxide fillers. The objective of the study was to review the results of previous studies that evaluated the effect of adding different types of nanoparticles on improving the silicone maxillofacial rehabilitation material mechanical properties.
METHODS
Search Methods: An electronic search in PubMed/Medline was used to find applicable papers that were published in English before September 2022.
Selection Criteria: By examining the title, abstract, and full text of the articles to ensure that they fit the inclusion criteria, the relevance of the articles was confirmed. The term was chosen based on the following: silicone elastomer as the population, nanoparticles as the intervention, and silicone elastomer with and without nanoparticle reinforcement as the comparison (mechanical properties).
Data Collection: Data regarding the published articles on the effect of adding nanoparticles to silicone material to enhance its mechanical properties has been collected.
RESULTS
Out of 27 articles, 18 articles met the requirements for data extraction for review of the results of studies that evaluated the effect of different nanoparticle addition on improving the mechanical properties of the silicone elastomer. Among the essential properties to be considered was that the silicone’s mechanical characteristics were enhanced by the incorporation of various nanoparticles at concentrations ranging from 1% to 3%.
CONCLUSIONS
An ideal maxillofacial silicone that exhibits perfect mechanical properties in a variety of human and environmental aging situations hasn't yet been found.
Optimizing Endoscopy Education in Gastroenterology Fellowship
Authors: Chalikonda Divya M. , Henry Christopher H. 
Published: October 2023

ABSTRACT
Education in endoscopy encompasses a wide breadth of topics and skills. Despite a shared interest in improving training in endoscopy, there is wide variation among programs, largely because of broad requirements put forth by the Accreditation Council on Graduate Medical Education. Historically, efforts to improve education in endoscopy were focused on numerics as a surrogate for competence. However, there is a role for “milestone” development goals to ensure trainees are on the right track to developing procedural competence. These milestones should encompass aspects of preprocedural assessment, intraprocedural technique, and postprocedural management and interpretation. Two important aspects of intraprocedural technique that are not universally emphasized among training programs but would be immensely beneficial to fellow education are (i) mucosal examination and (ii) device education. In this article, we will discuss the importance of developing the aforementioned skills and how we can approach a competency-based assessment of endoscopic skills during fellowship.
Increased Liver Enzymes: An Under-Recognized Finding in Maturity-Onset Diabetes of the Young Type 5 (MODY 5)
Authors: Veerareddy Sudiksha , Reddy Saigopala , Barreto Mauricio , Vedherey Niharika , Gopalareddy Vani V. 
Published: October 2023

ABSTRACT
Maturity-onset diabetes of the young type 5 (MODY 5) is characterized by a single gene mutation in the HNF1B gene. This frequently leads to insulin resistance and presents as young-onset diabetes. Other manifestations can occur in organs expressing hepatocyte nuclear factor-1 beta. This case report highlights family members with MODY 5 presenting with increased liver enzymes with no etiology. The siblings and their mother had a point mutation p.Arg235Trp in HNF1B gene located at 17q12. This variant is associated with autosomal dominant MODY 5 with renal cysts also known as renal cysts and diabetes syndrome.
Calcifying Nested Stromal-Epithelial Tumor: An Extremely Rare Hepatic Tumor
Authors: Khan Bilal Ahmed , Syed Imran Ali , Ulhaq Ihsan , Rashid Sohail , Khan Muhammad Yasir , Khalid Abdullah , Shafi Urfa , Aujla Usman Iqbal , Dar Faisal Saud 
Published: October 2023

ABSTRACT
Calcifying nested stromal-epithelial tumor is a rare hepatic malignancy with approximately 50 cases reported in the literature. Its clinical presentation is nonspecific, and the diagnosis is mainly based on histology which shows nests of spindle and epithelioid cells along with a desmoplastic myofibroblastic stroma containing variable calcification and ossification. In this report, we present a case of a 24-year-old woman with a history of abdominal pain, distension, and dyspepsia. She had a palpable liver with normal liver function test results. Serum alpha-fetoprotein levels were within normal range, and serologies for hepatitis B and C virus remained negative. Radiological investigations (magnetic resonance imaging and computed tomography) showed a large, right hepatic lobe mass with tumor invasion into the right posterior portal vein, but the 2 modalities could not characterize the lesion. Finally, an ultrasound-guided biopsy of the liver lesion provided the diagnosis of calcifying nested stromal-epithelial tumor. The tumor was resected successfully.
Preoperative Nasobiliary Drainage as a Predictor of Response Before Surgical Fistula Creation in Joubert Syndrome With Refractory Cholestatic Pruritis
Authors: Biermann Maya , Sundar Preeyanka Rubiana , Veeramachaneni Hima , Willingham Field 
Published: October 2023

ABSTRACT
Cholestatic pruritus is a debilitating symptom associated with many liver diseases and is often refractory to medical management. Nasobiliary drainage is a relatively safe and effective method for treating intractable cholestatic pruritus. It should be considered for patients with refractory cholestatic pruritus who have failed or have contraindications to medical therapy as a predictor of response before surgical fistula creation.
Development and Validation of Serum Markers as Noninvasive Diagnostic Methods for Achalasia
Authors: Jia Xingyu , Chen Songfeng , Hou Xun , Zhuang Qianjun , Tan Niandi , Zhang Mengyu , Wang Jinhui , Xing Xiangbin , Xiao Yinglian 
Published: October 2023

INTRODUCTION:
Currently, the diagnosis of achalasia mainly relies on invasive or radioactive examinations. This study aimed to develop a noninvasive diagnostic method for achalasia based on specific serum markers.

METHODS:
Serum levels of profilin-1, galectin-10, immunoglobulin heavy variable 3–9, vasodilator-stimulated phosphoprotein, and transgelin-2 were measured in patients with achalasia and controls by enzyme-linked immunosorbent assay. The diagnostic values and thresholds were determined by the receiver operating characteristic curve analysis. Then, patients with dysphagia were prospectively enrolled to validate the ability of these molecules for achalasia diagnosing.

RESULTS:
A total of 142 patients with achalasia and 50 nonachalasia controls (healthy volunteers and patients with reflux esophagitis) were retrospectively included. The serum levels of profilin-1, galectin-10, and transgelin-2 in patients with achalasia were significantly higher than those in healthy volunteers and patients with reflux esophagitis (P all < 0.001). Profilin-1, galectin-10, and transgelin-2 were of good performance in diagnosing achalasia, with optimal thresholds of 2,171.2, 33.9, and 1,630.6 pg/mL, respectively. Second, 40 patients with dysphagia were prospectively enrolled to the validation of achalasia. For profilin-1, the positive predictive value, negative predictive value, sensitivity, and specificity were 100.0%, 64.5%, 45.0%, and 100.0%, respectively. The figures for transgelin-2 were 65.5%, 90.9%, 95.0%, and 50.0%. When both increased, the positive predictive value reached to 100.0%. When both indexes were normal, the negative predictive value was 100.0%.

DISCUSSION:
Profilin-1 and transgelin-2 were promising biomarkers for achalasia diagnosis and performed better in combination. Further multicenter studies are necessary to verify their application as preliminary screening tools for achalasia.
Kerapatan Lamun dan Hubungan dengan Parameter Lingkungan di Perairan Pesisir Teluk Lampung
Authors: Isnaini Isnaini , Aryawati Riris 
Published: October 2023

Ekosistem lamun memiliki peranan sangat penting di wilayah pesisir. Seiring waktu wilayah pesisir menghadapi ancaman yang cukup besar akibat dari meningkatnya dan berkembangnya kegiatan pembangunan, seperti disebagian besar yang terjadi di ekosistem laut di Teluk Lampung. Penelitian ini bertujuan menentukan parameter lingkungan perairan yang mempengaruhi kerapatan lamun. Penelitian ini terdiri dari delapan stasiun yang ditentukan secara purposive sampling. Pengukuran parameter lingkungan perairan dilakukan secara insitu dan pengambilan contoh air. Pengambilan data kerapatan lamun menggunakan metode transek kuadrat. Analasis hubungan kerapatan lamun dengan parameter lingkungan perairan dianalisis menggunakan Analisis Komponen Utama (Principal Component Analysis/PCA). Hasil penelitian ditemukan sebanyak enam jenis lamun, yaitu Oceana serrulata, Enhalus acoroides Thalassia hemprichii, Halodule ovalis, Halodule pinifolia dan Halodule uninervis. Hubungan kerapatan lamun dengan parameter lingkungan perairan menunjukkan di kolom air kerapatan lamun dipengaruhi oleh nitrat (NO3), fosfat (PO4) dan salinitas, sedangkan untuk sedimen tempat tumbuh lamun, kerapatan lamun lebih dipengaruhi oleh kandungan C-organik dan tekstur sedimen lanau. Seagrass ecosystems have a very important role in coastal areas, but over time face considerable threats as a result of the increase and development of development activities in coastal areas, such as most of the marine ecosystem areas in Lampung Bay. This study aims to determine the parameters of the aquatic environment that affect the density of seagrass. This study consisted of eight stations determined by purposive sampling. Measurement of aquatic environmental parameters was carried out in situ and water samples were taken. Seagrass density data retrieval using the quadratic transect method. Analysis of the relationship between seagrass density and aquatic environmental parameters was analyzed using Principal Component Analysis (PCA). The results of the study found as many as six types of seagrass, namely Oceana serrulata, Enhalus acoroides Thalassia hemprichii, Halodule ovalis, Halodule pinifolia and Halodule uninervis. The relationship between seagrass density and aquatic environmental parameters shows that in the water column the density of seagrass is influenced by nitrate (NO3), phosphate (PO4) and salinity, while in sediments the density of seagrass is more influenced by organic C content and silt sediment texture.