bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond for Better and for Worse: Expanding Environmental Sensitivity into a Post-Traumatic Growth perspective
Authors: Sperati Alessandra , Spinelli Maria , Fasolo Mirco , Moscardino Ughetta , Passaquindici Ilenia , Straziuso Domenico , Gigliotti Gilberto , D'Urso Giulio , Pluess Michael , Lionetti Francesca 
Published: January 2024

Abstract

People differ in their responses to experiences with some showing a heightened Environmental Sensitivity (ES) for better and for worse. Highly sensitive people tend to get easily overwhelmed in adverse conditions but also to flourish in enriched environments. Yet, no studies have investigated whether people with a heightened ES may experience a positive outcome as well, in terms of Post-traumatic Growth (PTG), when a traumatic event occurs. This study provided a first empirical evidence regarding the relationship between ES and PTG on a general population of 2387 adults (age range: 18-88yy) surveyed online during the first Covid-19 lockdown. Correlations showed that ES was positively associated with PTG, though with a small effect size. Interaction effects from regression analyses provided evidence that the ES-PTG association was stronger when the individuals experienced anxiety to some extent, and not too much depression. To conclude, findings suggested highly sensitive people as not only more susceptible to adversities, but also more open to experience a growth when faced with challenging events. Identifying potential paths of growth in individuals who are more prone to negative feelings can have important implications for clinical practice as well as for theory by broadening our understanding of the concept of environmental sensitivity.
A miniature alternative to Cas9 and Cas12: Transposon-associated TnpB mediates targeted genome editing in plants
Authors: Molla Kutubuddin , Karmakar Subhasis , Panda Debasmita , Panda Sonali , Dash Manaswini , Saha Romio , Das Priya , Avinash SP , Shih Justin , Yang Yinong , Nayak Amaresh , Baig Mirza 
Published: January 2024

Abstract
Identifying and engineering RNA-guided genome editing nucleases for size reduction is a highly coveted pursuit aimed at overcoming various bottlenecks. The size reduction not only facilitates effective delivery but also contributes to the generation of fusion proteins, enabling versatile applications in genome engineering. In this study, we demonstrate high-efficiency genome editing in both monocots and dicots, with average editing rates ranging from 0.63% to 33.58% and reaching up to 69%, using a 408-amino acid-long transposon-associated TnpB. Furthermore, we repurpose a catalytically dead TnpB system for transcriptional activation and base editing. This miniature TnpB, approximately one-third the size of canonical Cas9/Cas12a, emerges as a highly valuable tool for diverse applications in plant genome engineering and gene regulation.
Mental Health Literacy and Information Needs of Young Persons with Psychosis and their Support Persons
Authors: Murphy Colleen , Hardman Madison P. , Reynolds Kristin A. , Mota Natalie 
Published: January 2024

Abstract

Background
First episode psychosis can significantly impact both young people and their loved ones who provide support. Recognizing that a young person is experiencing psychosis can be a crucial first step in accessing appropriate services. Higher mental health literacy may facilitate improved symptom recognition and reduce the stigma associated with psychosis. The aim of this research was to evaluate the mental health literacy and information needs of young people experiencing early-onset psychosis and of their loved ones who provide support.
Methods
Participants were recruited from an early psychosis clinic in Central Canada. A total of 57 service users and 43 support persons participated (N = 100) from December 2021 to February 2023. Data were collected through an online mixed-methods survey. Linear and logistic regressions were conducted to determine whether higher mental health literacy predicted improved outcomes among both groups (e.g., treatment satisfaction, psychiatric hospital admissions, use of crisis services). Linear regressions examined whether longer treatment predicted higher mental health literacy and lower information needs. Participants identified specific information needs and preferences through two open-ended questions, which were analyzed using Reflexive Thematic Analysis.
Results
Higher mental health literacy significantly predicted higher treatment satisfaction among service users and support persons, and lower stress levels among service users. Longer involvement in the treatment service significantly predicted greater willingness to seek information about psychosis from a pre-determined list of sources, including family, friends, and mental health clinicians. Both service users and support persons predominately had a moderate to good understanding of psychosis and did not endorse stigmatizing beliefs about psychosis. Both groups had a broad range of information preferences. Participants identified additional information needs related to the themes: Psychosis: Diagnosis and Recovery, Treatment, and Healthy Functioning; and preferred to learn content through Reliable Sources, Group Programming, and Peer Support.
Conclusions
Findings highlight the important role that mental health literacy can play in treatment satisfaction for both young persons experiencing psychosis and their support persons, and provide a better understanding of information needs and preferences of these groups. These findings have implications for both psychoeducation and treatment planning.
Extended Duration and Intense Manifestations of COVID-19-Linked Cytotoxic Lesions of the Corpus Callosum: Case Reports and Literature Review
Authors: Li Jing , Jia xiangdong , ge junling , yao guoen 
Published: January 2024

Abstract
While clinical instances of cytotoxic lesions of the corpus callosum (CLOCCs) are well-documented, international reports specific to COVID-19-related cases remain limited. This paper presents the case of a 40-year-old female patient admitted due to "sudden dizziness and poor limb coordination for 7 weeks following fever." She tested positive for COVID-19 and experienced symptoms like dizziness, temporary confusion, nausea, vomiting, cerebellar speech issues, and ataxia after fever onset. Later, she developed pyramidal tract symptoms and behavioral abnormalities. Head MRI revealed abnormal high signal in the splenium of the corpus callosum and abnormal signals in the left cerebellar peduncle on DWI. With no significant medical history and exclusion of other causes during treatment (including steroid therapy and two doses of intravenous immunoglobulin), a follow-up MRI after one month showed the lesions had disappeared. However, clinical recovery was slow, with residual symptoms persisting for almost a year, including involuntary tremors in the upper limbs and head. Phenytoin, gabapentin, and pregabalin showed limited effectiveness in treatment, but Arotinolol and donepezil led to slight improvement in involuntary tremors. This case suggests that COVID-19-associated CLOCCs might have a protracted course and severe symptoms, demanding differentiation from ischemic cerebrovascular diseases, particularly in early stages.
Unveiling Hybrid Teaching Efficacy: An Association Rule-Based Approach to Evaluating Quality
Authors: Chourasiya Leeladhar , Dwivedi Sunita 
Published: January 2024

Abstract
This paper presents a teaching quality evaluation method based on association rules, using the Analytic Hierarchy Process (AHP) and the Apriori algorithm to improve the effectiveness of the evaluation results of teaching quality in blended learning mode. The experimental results show that this method has a good teaching quality evaluation effect in the mixed teaching mode, with a high average coverage rate of quality evaluation indicators and correlation degree of quality evaluation model. These experimental results imply that the method employed in the study is not only thorough in evaluating various quality indicators but also efficient in terms of processing time. However, it's important to consider the specific indicators and methodologies used in the study, as well as the context in which the evaluation was conducted, to fully understand the implications and generalizability of the findings.
Mortality-related risk factors of carbapenem-resistant Enterobacteriaceae infection with focus on Antimicrobial regimens optimization: a real-world study in China
Authors: Deng Sheng , Chen Jinglan , Zhou Pengxiang , Hu Qin 
Published: January 2024

Abstract
Background To determine the mortality-related risk factors for carbapenem-resistant Enterobacteriaceae (CRE) infection in hospitalized patients and to compare the clinical efficacy of different antimicrobial regimens, mainly from the perspective of mortality.Methods Data were retrospectively collected from a 3,000-bed regional medical center with CRE infections between January 2021 and June 2022. The clinical characteristics, microbiological characteristics, and antimicrobial therapies of the patients with different outcomes were analyzed. Mortality-related risk factors were analyzed by the Cox proportional regression model for multivariate analysis.Results 120 patients were included. All patients received definitive therapy, and 65.0% (78/120) received active drug treatment. Among those receiving active drug treatment, 65.4% (51/78) received combination therapy, and 34.6% (27/78) received monotherapy. The all-cause mortality of CRE infection was 20.8% (25/120). Multivariate analysis showed that the length of hospital stay after CRE infection (hazard ratio [HR], 0.868; 95% confidence interval [CI], 0.806–0.936; P = 0.000), Sequential Organ Failure Assessment (SOFA) score (HR = 1.169; 95%CI, 1.066–1.281; P = 0.001), central venous catheter (HR = 3.858; 95%CI, 1.411–10.547; P = 0.009), age (HR = 1.035; 95%CI, 1.002–1.070; P = 0.036), and combination therapy (HR = 3.152; 95%CI, 1.205–8.245; P = 0.019) were independent mortality risk factors after CRE infection. Subgroup analysis of the non-sepsis group among 78 patients who received active drug treatment showed significantly lower mortality in monotherapy than in combination therapy (0% versus 22.2%, P = 0.034). Patients who received carbapenem-containing therapy had significantly higher mortality than those who received carbapenem-sparing therapy (31.3% versus 13.9%, P = 0.022).Conclusions Patients with a higher SOFA score, central venous catheter, shorter hospital stay after CRE infection, older age, and combination therapy had poor outcomes. Since patients with non-sepsis have a lower mortality rate from monotherapy, combination antibiotic treatment should not be routinely recommended to treat CRE infections.
Adherence to diabetes diet and glycemic control among type 2 diabetes mellitus adult patients attending diabetes clinics in selected hospitals, Addis Ababa, Ethiopia: a health facility based unmatched case-control study.
Authors: Eyob Mahlet , Desalegn Yakob , Mohammed Abdulrazak , Egata Gudina 
Published: January 2024

Abstract
Background
Suboptimal adherence to diabetes diet can drive the occurrence of diabetes complications. However, the association between adherence to diabetes diet and glycemic control was limited to non-analytical surveys and fasting blood sugar determinationin in low-income countries.
Objective
This study was aimed to assess the association between adherence to diabetes diet and glycemic control among adult type 2 DM patients on follow-up in selected hospitals, Addis Ababa, Ethiopia.
Methods
Hospital-based unmactched case-control study was conducted among 156 diabetes patients ( 104 controls and 52 cases ) from May to September 2022. Pretested structured questionnaire was used to collect data. Blood sugar level was tested using HgA1c test. Cases were patients with HgA1c < 7% while controls had HgA1c ≥ 7%. Descriptive statistics was used to describe all relevant data. Binary logistic regression analysis was done to assess the association between glycemic control and adherence to diabetes diet and other predictors. Adjusted odds ratios alongside 95% confidence intervals (CIs) were estimated to measure the strength of association between response and explanatory variables at p-value less than 0.05.
Results
A total of 156 type 2 diabetes patients were enrolled in this study. The mean (± SD) age of respondents was 52.65(± 9.94) and 51.04 (± 10.84) years among cases and controls respectively. In multivariable analysis, poor adherence to diabetes diet [(AOR = 3.89,95%CI:(1.58,9.54)] and diabetes medication [(AOR = 3.74,95% CI:(1.42,9.85)], lack of dietary education [(AOR = 4.97,95% CI:(1.56,15.87)], patient’s income level of ≤ 2500 Ethiopian birr (ETB) [(AOR = 3.17,95%CI:(1.24,8.07)], presence of diabetes comorbidities [(AOR = 4.78,95%CI:(1.37,16.71)] and diabetes complications [(AOR = 5.11,95%CI:( (1.60,15.87)] were significant determinants of poor glycemic control.
Conclusions
Poor dietary and medication -adherence ,lack of dietary education, low economic status, presence of comorbidities ,and diabetes complications were important determinants of poor glycemic control. Thus, health care providers should design appropriate interventions in line with modifiable determinants of poor glycemic control.
Mediolateral Upper-body Gyroscopic Moment Perturbations During Walking: Exploring Muscle Activation Patterns and Control Strategies
Authors: Mohseni Omid , Berry Andrew , Schumacher Christian , Seyfarth Andre , Vallery Heike , Sharbafi Maziar A. 
Published: January 2024

Abstract

Adaptive motor control and seamless coordination of muscle actions in response to external perturbations are crucial to maintaining balance during bipedal locomotion. There is an ongoing debate about the specific roles of individual muscles and underlying neural control circuitry that humans employ to maintain balance in different perturbation scenarios. To advance our understanding of human motor control in perturbation recovery, we conducted a study using a portable Angular Momentum Perturbator (AMP). Unlike other push/pull perturbation systems, the AMP can generate perturbation torques on the upper body while minimizing the perturbing forces at the center of mass. In this study, ten participants experienced trunk perturbations during either the mid-stance or touchdown phase in two frontal plane directions (ipsilateral and contralateral). We recorded and analyzed the electromyography (EMG) activity of eight lower-limb muscles from both legs to examine muscular responses in different phases and directions. Based on our findings, individuals primarily employ short-latency hip strategies to effectively counteract perturbation torques, with the occasional use of ankle strategies. Furthermore, it was found that proximal muscles such as Rectus Femoris, Hamstrings, and Tensor Fasciae Latae exhibited higher activation levels than other muscles. Additionally, we observed that the fastest reactions generally stem from muscles in close proximity to the perturbation site. However, the temporal sequence of muscles’ activation depends on the timing and direction of the perturbation. This suggests that, in response to unexpected torque perturbations, the body recruits the repertoire of muscles at its disposal, enabling effective coping with perturbations when necessary instead of relying on learned central motor programs. These findings enhance reflex response modeling, aiding the development of simulation tools for accurately predicting exogenous disturbances. Additionally, they hold the potential to shape the development of assistive devices, with implications for clinical interventions, particularly for the elderly.
Validation and assessment of psychometric properties of the Greek Eating Behaviors Assessment for Obesity (GR-EBA-O)
Authors: Mavrandrea Panagiota , Aloi Matteo , Geraci Matteo , Gonidakis Fragiskos , Segura-Garcia Cristina 
Published: January 2024

Abstract

Introduction
With increasing morbidity and risk of death, obesity has become a serious health problem largely attributable to difficulties in finding proper treatments for related diseases. Many studies show how detecting abnormal eating behaviors could be useful in developing effective clinical treatments. This study aims at validating the Greek version of the Eating Behaviors Assessment for Obesity (EBA-O).
Method
After a double English/Greek forward/backward translation of the EBA-O, 294 participants completed the Greek version (GR-EBA-O), the Eating Disorder Examination Questionnaire, the Binge Eating Scale, and the Yale Food Addiction Scale. Confirmatory factor analysis (CFA) and construct validity were calculated, and Two-way MANOVA was computed with the factors of GR-EBA-O controlling for sex and BMI categories.
Results
CFA confirmed the second-order five factors (i.e., food addiction, night eating, binge eating, sweet eating, and prandial hyperphagia) structure of the original EBA-O with excellent fit indices. GR-EBA-O factors were highly correlated. The GR-EBA-O subscales were also significantly correlated with the remaining measures, demonstrating good concurrent validity.
Conclusion
The Greek version of the EBA-O has demonstrated sound psychometric properties and appears a reliable and user-friendly tool to identify pathological eating behaviors in obesity.
Level of evidence:
Level V, descriptive research.
Which Social responsibility indicators impact Technical Efficiency of Public Sector Banks in India? Insights from supervised AI Techniques
Authors: Gupta Vipul , Layek Shirshendu , Bhushan Megha 
Published: January 2024

Abstract
In economics, the concept of Social Responsibility (SR) emerged in the late 1970s with the critical words of Milton Friedman. The term SR implies the responsibility obliged towards society from which various institutions derive the benefits. The present work aims to analyze the impact of social responsibility on the technical efficiency of Public Sector Banks (PSBs) with artificial intelligence podiums. It also identifies an important social responsibility indicator inclusive of four dimensions of SR. Mathematically extracting the importance of each parameter related to the efficiency metrics is tedious. Therefore, supervised machine learning algorithms like Random Forest (RF) and XGBoost (XGB) are applied in this study.
Furthermore, banks' effective implementation of SR policy for sustainable development is discussed based on supervised learning. In this study, the impact of 46 social responsibility indicators on the technical efficiency of PSBs is investigated using Machine Learning and non-parametric techniques. Furthermore, the present paper adds to the body of literature by analyzing which indicator of responsibility better influences bank efficiency using a machine learning model. The results revealed that an important indicator impacting efficiency concerning constant and variable return to scale is an area of specialization and background of employees working in PSBs. This showed that PSBs must look towards their work efficiency towards their employees and staff regarding social responsibility.
JEL Classification: B22, C12, G30, G38
Analyzing the topological properties of resting-state brain function network connectivity based on graph theoretical methods in patients with high myopia
Authors: Wei Bin , Huang Xin , Ji Yu , Fu Wen-Wen , Cheng Qi , Shu Ben-Liang , Huang Qin-Yi , Chai Hua , Zhou Lin , Hao-Yu Hao-Yu , Wu Xiao-Rong 
Published: January 2024

Abstract
Aim
Recent imaging studies have found significant abnormalities in the brain’s functional or structural connectivity among patients with high myopia (HM), indicating a heightened risk of cognitive impairment and other behavioral changes. However, there is a lack of research on the topological characteristics and connectivity changes of the functional networks in HM patients.In this study, we employed graph theoretical analysis to investigate the topological structure and regional connectivity of the brain function network in HM patients.
Methods
We conducted rs-fMRI scans on 82 individuals with HM and 59 healthy controls (HC), ensuring that the two groups were matched for age and education level. Through graph theoretical analysis, we studied the topological structure of whole-brain functional networks among participants, exploring the topological properties and differences between the two groups.
Results
In the range of 0.05 to 0.50 of sparsity, both groups demonstrated a small-world architecture of the brain network. Compared to the control group, HM patients showed significantly lower values of γ(P = 0.0101) and σ(P = 0.0168). Additionally, the HM group showed lower nodal centrality in the right Amygdala (P<0.001, Bonferroni-corrected). Notably, there is an increase in functional connectivity (FC) between the SN and SMN in the HM group, while the strength of FC between the basal ganglia is relatively weaker (P<0.01).
Conclusion
HM Patients exhibit reduced small-world characteristics in their brain networks, with significant drops in γ and σ values indicating weakened global interregional information transfer ability. Not only that, the topological properties of the amygdala nodes in HM patients significantly decline, indicating dysfunction within the brain network.In addition, there are abnormalities in the FC between the saliency network (SN) , Sensorimotor Network (SMN), and basal ganglia networks in HM patients , which is related to attention regulation, motor impairment, emotions, and cognitive performance. These findings may provide a new mechanism for central pathology in HM patients.
The enhanced selectivity of oxygen delignification of kraft pine wood pulps: The effects of pentosane-based cherry and guar gum additions
Authors: İskefyeli Ayşegül , Kırcı Hüseyin , Kalyoncu Evren Ersoy , Erişir Emir 
Published: January 2024

Abstract
The objective of this study was to decrease the adverse effects of radicals created in the reaction medium by adding cherry gum or guar gum, which are sugar-based polymers, into the oxygen delignification (OD) solution used in the bleaching process of pine wood pulp produced by the kraft process. In order to enhance the dissolution of lignin, peroxide was introduced into the oxygen delignification solution, resulting in the formation of a more intensive oxidative environment. The impact of each gum addition on cellulose and hemicelluloses during oxidation processes was assessed by determining pulp viscosity, kappa number, and yield values. The addition of 2% cherry gum to the OD pulp resulted in a 2.1% increase in the removal of residual lignin and a 1.9% increase in viscosity compared to the pulp without cherry gum. Similar results were also achieved in the examination of OD pulps reinforced with guar gum. The study revealed that using cherry gum and peroxide-reinforced OD pulps resulted in the lightest-colored pulps. It was observed that additions of both gums increased the strength of the pulp except for the tearing index.