bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorescence determination of 3-MCPD by combining amino silica nanoparticles with fluorescein isothiocyanate
Authors: Xu Ting , Qingru Zeng , Fu Qing , Wang Zhaojie , Liu Xin , Xiao Shensheng , Jiang Xiaoming , Lu Yuepeng , Gong Zhiyong , Wu Yongning , Fang Min 
Published: October 2023

AbstractUsing amino silica modified with fluorescein isothiocyanate (FITC), a quick fluorescence analysis technique is used for the detection of 3-monochloropropane-1,2-diol (3-MCPD). At 100 °C and pH 8.5, FITC-modified amino silica exhibits the lowest fluorescence intensity in the presence of 3-MCPD. This can predominantly be explained mostly explained by 3-MCPD’s capacity to occupy the amino group that FITC normally binds to. The fluorescence intensity of FITC-modified amino silica was greatly quenched by 3-MCPD’s reaction with the amino group under alkaline conditions, and the fluorescence intensity is different at different reaction times, reaction pH, and reaction temperature. The effects of various 3-MCPD concentrations on the optical characteristics of FITC-modified amino silica were also investigated. Fluorescence analysis is used to obtain a linear range from 0.025 to 1.0 mg/L for 3-MCPD detection under optimal experimental conditions, with a detection limit of 0.025 mg/L and a correlation coefficient of 0.9915. The quantity of 3-MCPD in soy sauce was measured under ideal conditions. Using the optimized conditions, the contents of 3-MCPD in soy sauce were determined. These results suggest that this method is sensitive to 3-MCPD and may have a substantial application in the rapid detection of food contaminants particularly, where the quality and safety of food products are of paramount concern.
An enhanced version of FREM (Fracture Risk Evaluation Model) using national administrative health data: analysis protocol for development and validation of a multivariable prediction model
Authors: Kristensen Simon Bang , Clausen Anne , Skjødt Michael Kriegbaum , Søndergaard Jens , Abrahamsen Bo , Möller Sören , Rubin Katrine Hass 
Published: October 2023

Abstract
Background
Osteoporosis poses a growing healthcare challenge owing to its rising prevalence and a significant treatment gap, as patients are widely underdiagnosed and consequently undertreated, leaving them at high risk of osteoporotic fracture. Several tools aim to improve case-finding in osteoporosis. One such tool is the Fracture Risk Evaluation Model (FREM), which in contrast to other tools focuses on imminent fracture risk and holds potential for automation as it relies solely on data that is routinely collected via the Danish healthcare registers. The present article is an analysis protocol for a prediction model that is to be used as a modified version of FREM, with the intention of improving the identification of subjects at high imminent risk of fracture by including pharmacological exposures and using more advanced statistical methods compared to the original FREM. Its main purposes are to document and motivate various aspects and choices of data management and statistical analyses.

Methods
The model will be developed by employing logistic regression with grouped LASSO regularization as the primary statistical approach and gradient-boosted classification trees as a secondary statistical modality. Hyperparameter choices as well as computational considerations on these two approaches are investigated by an unsupervised data review (i.e., blinded to the outcome), which also investigates and handles multicollinarity among the included exposures. Further, we present an unsupervised review of the data and testing of analysis code with respect to speed and robustness on a remote analysis environment. The data review and code tests are used to adjust the analysis plans in a blinded manner, so as not to increase the risk of overfitting in the proposed methods.

Discussion
This protocol specifies the planned tool development to ensure transparency in the modeling approach, hence improving the validity of the enhanced tool to be developed. Through an unsupervised data review, it is further documented that the planned statistical approaches are feasible and compatible with the data employed.
Evaluation of chlorpyrifos and Beauveria bassiana as a strategy in the Egyptian sugar beet fields: impact on Spodoptera littoralis (Boisduval) and its associated predators populations and the sugar beetroot yield
Authors: Fergani Yasmin Adel , Refaei Elsayed Abd Elhameed , Faiz Neven Mohamed , Hamama Heba Mohamed 
Published: October 2023

Abstract
Background
The susceptibility of pests and natural enemies to conventional insecticides is a critical element in judging the success of integrated pest management programs implementing biological control as a tactic. In this study, the susceptibility of the cotton leafworm Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) to an organophosphorus insecticide (chlorpyrifos) and the entomopathogenic fungus Beauveria bassiana was evaluated through field applications during two successive sugar beet seasons. The populations of the coccinellid, chrysopid, and formicid predators were estimated to indicate pesticide risk assessment strategy. The root and sugar yields were compared during the whole experiment to emphasize the impact of both control strategies on the pre-harvest loss in this strategic crop.

Results
Results indicated that over the course of the two seasons of the investigation, chlorpyrifos significantly reduced the population density of S. littoralis and its associated predators. It showed a detrimental effect on S. littoralis larval population than untreated areas, causing an overall reduction of 97 and 92% during the 1st and 2nd seasons, respectively. The biopesticide based on entomopathogenic fungus Beauveria bassiana caused an overall reduction of S. littoralis, reaching 96 and 65% during the 1st and 2nd seasons, respectively. Meanwhile, B. bassiana slightly affects the population of predators compared to insecticide-free areas, so it was recommended for application in sugar beet fields without providing considerable risk to the associated insect predators. The sugar beetroot production and its sugar content increased significantly in both treatments during the two growing seasons compared to non-treated plots.

Conclusion
Chlorpyrifos is not recommended for pest control; instead, B. bassiana is considered an effective biopesticide in the Egyptian sugar beet fields infested with S. littoralis as part of an integrated pest management program. Their effect was direct through reducing pest population and indirectly increasing the sugar beetroot production and increasing its total sugar content. Hence, both the sugar beetroot quality and quantity were improved favoring the microbial agent over the chemical insecticide in application for mitigating the chemical hazards toward the associated predators.
Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100β under high-altitude conditions
Authors: Xie Huichao , Zeng Xiong , Wang Wensheng , Wang Wei , Han Ben , Tan QianShan , Hu Qiu , Liu Xingyu , Chen Shuaishuai , Chen Jun , Sun Lihua , Chen Yihui , Xiao Weidong 
Published: October 2023

AbstractDamage to the intestinal epithelial barrier (IEB) has been reported under high-altitude (HA) conditions and may be responsible for HA-associated gastrointestinal (GI) disorders. However, this pathogenetic mechanism does not fully explain the GI stress symptoms, such as flatulence and motility diarrhea, which accompany the IEB damage under HA conditions, especially for the people exposed to HA acutely. In the present study, we collected the blood samples from the people who lived at HA and found the concentration of enteric glial cells (EGCs)-associated biomarkers increased significantly. HA mouse model was then established and the results revealed that EGCs were involved in IEB damage. Zona occludens (ZO)-1, occludin, and claudin-1 expression was negatively correlated with that of glial fibrillary acidic protein (GFAP) and S100β under HA conditions. In order to learn more about how EGCs influence IEB, the in vitro EGC and MODE-K hypoxia experiments that used hypoxic stimulation for simulating in vivo exposure to HA was performed. We found that hypoxia increased S100β secretion in EGCs. And MODE-K cells cultured in medium conditioned by hypoxic EGCs showed low ZO-1, occludin, and claudin-1 levels of expression. Furthermore, treatment of MODE-K cells with recombinant mouse S100β resulted in diminished levels of ZO-1, occludin, and claudin-1 expression. Thus, HA exposure induces greater S100β secretion by EGCs, which aggravates the damage to the IEB. This study has revealed a novel mechanism of IEB damage under HA conditions, and suggest that EGCs may constitute a fresh avenue for the avoidance of GI disorders at HA.
‘It's a girl!’ Is gender disappointment a mental health or sociocultural issue?
Authors: Jayarajah Chrissy 
Published: October 2023

SummaryGender disappointment can be defined as subjective feelings of sadness when discovering that the sex/gender of a child is the opposite of what the parent had hoped or expected. Wanting a boy (or ‘son preference’) has long been noted in many cultures, particularly in South and East Asian communities, but it is now becoming more recognised in the UK, Europe and North America. This article aims to improve understanding of gender disappointment by exploring medical and social sciences research; it also discusses the clinical and risk implications of assessing and managing gender disappointment (or not doing so) when individuals present to perinatal and/or community mental health services.
Functionalised Carbon Nanotubes: Promising Drug Delivery Vehicles for Neurovascular Disorder Intervention
Authors: Komane Patrick , Kumar Pradeep , Choonara Yahya 
Published: October 2023

AbstractNeurovascular diseases are linked to the brain’s blood vessels. These disorders are complicated to treat due to the strict selective characteristics of the blood–brain barrier. Consequently, the potency of the pharmacological treatments for these conditions is immensely diminished, leading to a rise in neurovascular-associated morbidity and mortality. Carbon nanotubes are regarded as essential nanoparticles with a promise of treating neurovascular disorders. Current findings have demonstrated the effectiveness of carbon nanotubes as vehicles for ferrying drugs to the site of interest. This review accentuates the theoretical utilisation of carbon nanotubes as drug nanocarriers equipped with the penetrating capability to the blood–brain barrier for treating neurovascular disorders such as ischemic stroke. The success of the carbon nanotube system may result in the development of a new and highly relevant drug delivery procedure. This review will also cover carbon nanotube functionalisation for applications in the biomedical fields, toxicity, in vitro and in vivo drugs and biomolecule delivery, and the future outlook of carbon nanotubes.
Graphical Abstract
ITO-based UV dielectric metasurface absorber: Achieving polarization-insensitive operation
Authors: Houran Mohamad Abou , Saqlain Muhammad , Baqir Muhammad Abuzar 
Published: October 2023

Abstract
In this paper, a metasurface-based ultraviolet absorber made of periodically arranged nanospheres of indium tin oxide (ITO) is studied. The wideband absorptivity was observed due to photonics resonance of the top metasurface with an aggregative absorption of over 85% within the 200–320 nm operating range. The proposed absorber features insensitivity to different polarized waves. Furthermore, we employ the Fabry-Pérot model to understand the absorption mechanism and these results show a fair agreement with our simulated work. This absorber can be useful to use in applications related to photodetection conversion and ultraviolet protection.
Thick Description for Critical AI: Generating Data Capitalism and Provocations for a Multisensory Approach
Authors: Schuster Caroline E. , Schuster Kristen M. 
Published: October 2023

Abstract
This article argues that critical AI studies should make a methodological investment in “thick description” to counteract the tendency both within computational design and business settings to presume (or, in the case of start-ups, hope for) a seamless and inevitable journey from data to monetizable domain knowledge and useful services. Perhaps the classic application of that critical data-studies framework is Marion Fourcade and Kevin Healy's influential 2017 essay, “Seeing Like a Market,” which advances a comprehensive account of how value is extracted from data-collection processes. As important as these critiques have been, the apparent inevitability of this assemblage of power, knowledge, and profit arises in part through the metaphor of “sight.” Thick description—especially when combined with a feminist and queer attention to embodiment, materiality, and multisensory experience—can in this respect supplement Fourcade and Healey's critique by revealing unexpected imaginative possibilities built out of social materialities.
Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis
Authors: Yang Mingyao , Ma Wenzhi , Oatley Jon , Liu Wan-Sheng 
Published: October 2023

ABSTRACT
Spermatogenesis begins when cell fate-committed prospermatogonia migrate to the basement membrane and initiate spermatogenesis in response to retinoic acid (RA) in the neonatal testis. The underlying cellular and molecular mechanisms in this process are not fully understood. Here, we report findings on the involvement of a cancer/testis antigen, PRAMEL1, in the initiation and maintenance of spermatogenesis. By analyzing mouse models with either global or conditional Pramel1 inactivation, we found that PRAMEL1 regulates the RA responsiveness of the subtypes of prospermatogonia in the neonatal testis, and affects their homing process during the initiation of spermatogenesis. Pramel1 deficiency led to increased fecundity in juvenile males and decreased fecundity in mature males. In addition, Pramel1 deficiency resulted in a regional Sertoli cell-only phenotype during the first round of spermatogenesis, which was rescued by administration of the RA inhibitor WIN18,446, suggesting that PRAMEL1 functions as an inhibitor of RA signaling in germ cells. Overall, our findings suggest that PRAMEL1 fine-tunes RA signaling, playing a crucial role in the proper establishment of the first and subsequent rounds of spermatogenesis.
Major Intraoperative Complications During Minimally Invasive Esophagectomy
Authors: Söderström H. , Moons J. , Nafteux P. , Uzun E. , Grimminger P. , Luyer M. D. P. , Nieuwenhuijzen G. A. P. , Nilsson M. , Hayami M. , Degisors S. , Piessen G. , Vanommeslaeghe H. , Van Daele E. , Cheong E. , Gutschow Ch A. , Vetter D. , Schuring N. , Gisbertz S. S. , Räsänen J. 
Published: October 2023

Abstract
Background
Studies have shown minimally invasive esophagectomy (MIE) to be a feasible surgical technique in treating esophageal carcinoma. Postoperative complications have been extensively reviewed, but literature focusing on intraoperative complications is limited. The main objective of this study was to report major intraoperative complications and 90-day mortality during MIE for cancer.

Methods
Data were collected retrospectively from 10 European esophageal surgery centers. All intention-to-treat, minimally invasive laparoscopic/thoracoscopic esophagectomies with gastric conduit reconstruction for esophageal and GE junction cancers operated on between 2003 and 2019 were reviewed. Major intraoperative complications were defined as loss of conduit, erroneous transection of vascular structures, significant injury to other organs including bowel, heart, liver or lung, splenectomy, or other major complications including intubation injuries, arrhythmia, pulmonary embolism, and myocardial infarction.

Results
Amongst 2862 MIE cases we identified 98 patients with 101 intraoperative complications. Vascular injuries were the most prevalent, 41 during laparoscopy and 19 during thoracoscopy, with injuries to 18 different vessels. There were 24 splenic vascular or capsular injuries, 11 requiring splenectomies. Four losses of conduit due to gastroepiploic artery injury and six bowel injuries were reported. Eight tracheobronchial lesions needed repair, and 11 patients had significant lung parenchyma injuries. There were 2 on-table deaths. Ninety-day mortality was 9.2%.

Conclusions
This study offers an overview of the range of different intraoperative complications during minimally invasive esophagectomy. Mortality, especially from intrathoracic vascular injuries, appears significant.
The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy
Authors: Filipe W. F. , Meyer Y. M. , Buisman F. E. , van den Braak R. R. J. Coebergh , Galjart B. , Höppener D. J. , Jarnagin W. R. , Kemeny N. E. , Kingham T. P. , Nierop P. M. H. , van der Stok E. P. , Grünhagen D. J. , Vermeulen P. B. , Groot Koerkamp B. , Verhoef C. , D’Angelica M. I. 
Published: October 2023

Abstract
Background
Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP is associated with multi-organ recurrence and inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy in CRLM.

Methods
Patients undergoing resection of CRLM and perioperative systemic chemotherapy in two centers were included. Survival outcomes and the predictive value of HAIP versus no HAIP per HGP group were evaluated through Kaplan–Meier and Cox regression methods, respectively.

Results
We included 1233 patients. In the dHGP group (n = 291, 24%), HAIP chemotherapy was administered in 75 patients (26%). In the non-dHGP group (n = 942, 76%), HAIP chemotherapy was administered in 247 patients (26%). dHGP was associated with improved overall survival (OS, HR 0.49, 95% CI 0.32–0.73, p < 0.001). HAIP chemotherapy was associated with improved OS (HR 0.61, 95% CI 0.45–0.82, p < 0.001). No interaction could be demonstrated between HGP and HAIP on OS (HR 1.29, 95% CI 0.72–2.32, p = 0.40).

Conclusions
There is no evidence that HGPs of CRLM modify the survival benefit of adjuvant HAIP chemotherapy in patients with resected CRLM.
“Waiting for the best day of your life”. A qualitative interview study of patients’ and clinicians’ experiences of Perthes’ disease
Authors: Galloway Adam M. , Pini Simon , Holton Colin , Perry Daniel C. , Redmond Anthony , Siddle Heidi J. , Richards Suzanne 
Published: October 2023

AimsPerthes’ disease is an idiopathic avascular necrosis of the developing femoral head, often causing deformity that impairs physical function. Current treatments aim to optimize the joint reaction force across the hip by enhancing congruency between the acetabulum and femoral head. Despite a century of research, there is no consensus regarding the optimal treatment. The aim of this study was to describe the experiences of children, their families, and clinicians when considering the treatment of Perthes’ disease.MethodsA qualitative study gathered information from children and their families affected by Perthes’ disease, along with treating clinicians. Interviews followed a coding framework, with the interview schedule informed by behavioural theory and patient and public involvement. Transcripts were analyzed using the framework method.ResultsA total of 24 interviews took place, with 12 child/family dyads and 12 clinicians from UK NHS centres. Interviews identified widespread variation of routine care. Children/their families recounted positive experiences when included in the decision-making process for treatment. There is a strong desire from clinicians and children/families for consistent guidance from everyone involved in care, which should be based on clinical consensus.ConclusionThis is the first study to describe how children/families and clinicians experienced receiving or providing treatment in Perthes’ disease. The results indicate the need for robust evidence to support treatment decisions. Children and families valued feeling involved in the clinical decision-making process. Clinicians acknowledged the central importance of providing patient-centred care, particularly in the absence of robust evidence to guide the optimal treatment decisions. This study will inform a future Delphi project to develop clinical consensus guidelines for the treatment of Perthes’ disease.Cite this article: Bone Jt Open 2023;4(10):735–741.
Single-mode regenerative amplification in multimode fiber
Authors: Haig Henry , Bender Nicholas , Eisenberg Yishai , Wise Frank 
Published: October 2023

The peak power performance of ultrafast fiber lasers scales with fiber
mode area, but large fibers host multiple modes that are difficult to
control. We demonstrate a technique for single-mode operation of
highly multimode fiber based on regenerative amplification. This
results in a short-pulse fiber source with, to our knowledge, an
unprecedented combination of features: high gain (>55dB) with negligible amplified
spontaneous emission, high pulse energy (>50µJ), good beam quality (M2≤1.3), and transform-limited
(300 fs) pulses from a single amplification stage. We discuss
peak intensity scaling to much higher levels and other opportunities
for short-pulse generation in regenerative fiber amplifiers.
Scaling Up Innovation - Exemplary Initiatives for Sustainable Development in European Smart Cities with a Focus on Smart Mobility
Authors: Derlukiewicz Niki , Szałata Łukasz , Mańkowska Dominika 
Published: October 2023

The development of a sustainable economy is the goal of the whole society in the European Union. With over half of the global population residing in urban areas, the significance of building resilient cities cannot be overstated. Cities are at the forefront of driving adaptation and building resilience implementing ambitious strategies and activities to effectively cope, adapt, and transform, considering three pillars of sustainable development: economic growth, environmental management and social inclusion. This study explores the toolbox of best practices - activities and innovations that European cities are implementing to achieve sustainable development goals. In the article, the best practices and innovative approaches that cities are taking toward sustainability were identified. This article explores the key aspects of smart mobility and its potential to reshape urban transportation systems for a more sustainable future. The findings in the paper indicate that European cities are making significant efforts to adopt sustainable practices, including investments in renewable energy, green infrastructure, public transportation, waste management, and sustainable urban planning. The study highlights the importance of the need for inter-sectoral collaborations to achieve SD goals. The insights gained from this study can inform policy-making and assist cities in developing effective strategies for sustainable development.
Keywords: smart city, innovation, sustainable development, urban development, smart mobility