bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of the Russo-Ukrainian War on the Bilateral Trade in the Region: Evidence from a Panel Gravity Model
Authors: Korkmaz Özge , Karacan Semih 
Published: October 2023

This study aims to investigate the regional impact of the sanctions imposed by the West on the Russian Federation. To this end, we used two samples to estimate the determinants of bilateral trade. The first dataset belongs to ex-Soviet countries between 1992 and 2019, and the second dataset expands it with bilateral trade data relating to China, Iran and Turkey. The results reveal that there are structural differences between the two samples regarding the determinants of the bilateral trade flows and sanctions that have spillover effects in the region. We also projected our findings to the recent events. JEL Codes: C33, F13, F14
Olanzapine-Samidorphan for Schizophrenia: A Systematic Review and Meta-Analysis
Authors: Gupta Dhyuti , Singh Alok 
Published: October 2023

Background and Objective: United States Food and Drug Administration (USFDA) recently approved a novel combination of olanzapine-samidorphan (OLZSAM) for managing olanzapine-associated adverse events (weight gain) in adult patients with schizophrenia and bipolar disorder. To opine about the safety and efficacy of OLZSAM, authors performed a systematic review and meta-analysis to convene justifiable evidence. Methods: A thorough literature search was performed through the databases Embase, Cochrane Library, PubMed, and clinicaltrials.gov, from inception to September 2022, with the keywords: ‘olanzapine and samidorphan’ and schizophrenia; and “ALKS3831” and “lybalvi.” Clinical trials published in English that analyzed the efficacy and safety of OLZSAM were included. The significant outcomes included in this study were change from baseline (CFB) in Positive and Negative Syndrome Scale (PANSS) at the end of the study, the proportion of patients with weight gain at the end of the study, the proportion of patients with at least one adverse event, and the incidence of drug discontinuation due to adverse events. Results: The change in PANSS score at the end of the study was comparable among groups receiving OLZSAM and olanzapine alone: standardized mean difference (SMD) = 0.04; 95% CI = -0.09 to 0.17; p = 0.57. The OLZSAM group reported less incidence of weight gain: risk ratio (RR) = 0.91; 95% CI = 0.62–1.34; p = 0.63, and any adverse event: RR = 0.99; 95% CI = 0.90–1.09; p = 0.81. Drug discontinuation incidence was higher in the OLZSAM group: RR = 1.22; 95% CI = 0.84–1.79; p = 0.30. Conclusions: The combination OLZSAM showed comparable efficacy to olanzapine alone in schizophrenia patients, with relatively less incidence of weight gain and adverse events; however, the drug discontinuation due to adverse events was more in the OLZSAM group.
Validity of the self-administered comorbidity questionnaire in patients with inflammatory bowel disease
Authors: van Linschoten Reinier Cornelis Anthonius , Huberts Anouk Sjoukje , van Leeuwen Nikki , Hazelzet Jan Antonius , van der Woude Janneke , West Rachel Louise , van Noord Desirée , de Jonge V. , Wolfhagen F. H. J. , Bodelier A. G. L. , Hoekstra J. , van der Woude C. J. , de Vries A. C. , West R. L. , van Noord D. , van Linschoten R. C. A. , Visser E. , Verweij K. E. , Kubben F. J. G. M. , Holster I.L. , Fitzpatrick C. E. , Robbers K. , Vermeulen H. G. , van der Wiel S. K. , Jansen S. V. 
Published: October 2023

Background: The International Consortium for Health Outcomes Measurement has selected the self-administered comorbidity questionnaire (SCQ) to adjust case-mix when comparing outcomes of inflammatory bowel disease (IBD) treatment between healthcare providers. However, the SCQ has not been validated for use in IBD patients. Objectives: We assessed the validity of the SCQ for measuring comorbidities in IBD patients. Design: Cohort study. Methods: We assessed the criterion validity of the SCQ for IBD patients by comparing patient-reported and clinician-reported comorbidities (as noted in the electronic health record) of the 13 diseases of the SCQ using Cohen’s kappa. Construct validity was assessed using the Spearman correlation coefficient between the SCQ and the Charlson Comorbidity Index (CCI), clinician-reported SCQ, quality of life, IBD-related healthcare and productivity costs, prevalence of disability, and IBD disease activity. We assessed responsiveness by correlating changes in the SCQ with changes in healthcare costs, productivity costs, quality of life, and disease activity after 15 months. Results: We included 613 patients. At least fair agreement (κ > 0.20) was found for most comorbidities, but the agreement was slight (κ < 0.20) for stomach disease [κ = 0.19, 95% CI (−0.03; 0.41)], blood disease [κ = 0.02, 95% CI (−0.06; 0.11)], and back pain [κ = 0.18, 95% CI (0.11; 0.25)]. Correlations were found between the SCQ and the clinician-reported SCQ [ρ = 0.60, 95% CI (0.55; 0.66)], CCI [ρ = 0.39, 95% CI (0.31; 0.45)], the prevalence of disability [ρ = 0.23, 95% CI (0.15; 0.32)], and quality of life [ρ = −0.30, 95% CI (−0.37; −0.22)], but not between the SCQ and healthcare or productivity costs or disease activity (|ρ| ⩽ 0.2). A change in the SCQ after 15 months was not correlated with a change in any of the outcomes. Conclusion: The SCQ is a valid tool for measuring comorbidity in IBD patients, but face and content validity should be improved before being used to correct case-mix differences.
Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model
Authors: Xue Ling , Song Lin , Yu Xun , Yang Xiao , Xia Fan , Ding Xiaoliang , Huang Chenrong , Wu Depei , Miao Liyan 
Published: October 2023

Background: Acute graft- versus-host disease (aGVHD) is a major complication following hematopoietic stem cell transplantation (HSCT). Objective: This study aimed to explore the risk factors for the incidence of aGVHD in patients post-HSCT. Design: This was a retrospective study. Methods: A total of 407 patients were enrolled. The patients’ data were recorded from the medical records. The exposure of cyclosporine was estimated based on a population pharmacokinetics model. The occurrence of aGVHD was clinically graded and staged in severity from grades I to IV. A proportional odds model that estimated the cumulative probabilities of aGVHD was used to analyze the data using a nonlinear mixed-effects model. Then, the model parameters and plausibility were evaluated by bootstrap and visual predictive checks. Results: The typical probabilities were 18.9% and 17.9% for grade II and grades III–IV, respectively. The incidence of grade II and grade III–IV aGVHD for human leukocyte antigen (HLA) haplo sibling donor patients was higher than that for HLA-matched donor patients. The incidence of grade II and grade III–IV aGVHD decreased with increasing early cyclosporine trough concentration; however, cyclosporine exposure was not associated with the incidence of aGVHD. Conclusion: HLA matching and early cyclosporine trough concentration were important factors for the occurrence of aGVHD.
Corrosion analysis of unearthed jade from Daye Zhen Tomb of Northern Zhou Dynasty
Authors: Zhang Kexin , Zhang Yaxu , Zhao Jing , Zhao Zhanrui , Zhao Meng , Zhao Xichen , Luo Hongjie 
Published: October 2023

Abstract
X-ray fluorescence spectroscopy, scanning electron microscopy energy spectrum, excitation-emission matrix spectroscopy, and Fourier transform infrared spectroscopy was applied to the unearthed jade with multilayered corrosion, to reveal the microstructure, composition structure, and distribution of organic matters. Our results showed that the interior of the jade was mainly composed of layered serpentine with a regular structure, while the white layer structure on the surface is scattered and irregular, and the content of calcite formed by elements Ca and C increases significantly; between the green matrix and the white layer on the surface, there are brown corrosion zones with obvious fluorescence effect and mainly composed of humic acid, which continuously extends inward along the corrosion cracks for accelerating the internal corrosion. This article, for the first time, argued for the corrosive and fluorescent humic acid bands that appear inside serpentine jade and cautions its role in investigating the corrosion of jade.
Nomograms integrating CT radiomic and deep learning signatures to predict overall survival and progression-free survival in NSCLC patients treated with chemotherapy
Authors: Chang Runsheng , Qi Shouliang , Wu Yanan , Yue Yong , Zhang Xiaoye , Qian Wei 
Published: October 2023

Abstract
Objectives
This study aims to establish nomograms to accurately predict the overall survival (OS) and progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC) who received chemotherapy alone as the first-line treatment.

Materials and methods
In a training cohort of 121 NSCLC patients, radiomic features were extracted, selected from intra- and peri-tumoral regions, and used to build signatures (S1 and S2) using a Cox regression model. Deep learning features were obtained from three convolutional neural networks and utilized to build signatures (S3, S4, and S5) that were stratified into over- and under-expression subgroups for survival risk using X-tile. After univariate and multivariate Cox regression analyses, a nomogram incorporating the tumor, node, and metastasis (TNM) stages, radiomic signature, and deep learning signature was established to predict OS and PFS, respectively. The performance was validated using an independent cohort (61 patients).

Results
TNM stages, S2 and S3 were identified as the significant prognosis factors for both OS and PFS; S2 (OS: (HR (95%), 2.26 (1.40–3.67); PFS: (HR (95%), 2.23 (1.36–3.65)) demonstrated the best ability in discriminating patients with over- and under-expression. For the OS nomogram, the C-index (95% CI) was 0.74 (0.70–0.79) and 0.72 (0.67–0.78) in the training and validation cohorts, respectively; for the PFS nomogram, the C-index (95% CI) was 0.71 (0.68–0.81) and 0.72 (0.66–0.79). The calibration curves for the 3- and 5-year OS and PFS were in acceptable agreement between the predicted and observed survival. The established nomogram presented a higher overall net benefit than the TNM stage for predicting both OS and PFS.

Conclusion
By integrating the TNM stage, CT radiomic signature, and deep learning signatures, the established nomograms can predict the individual prognosis of NSCLC patients who received chemotherapy. The integrated nomogram has the potential to improve the individualized treatment and precise management of NSCLC patients.
Assessment of telepsychiatry services provided by Okasha Institute of Psychiatry during COVID-19 pandemic
Authors: Sayed Maha , Gafary Maha el , Mohsen Nesreen , Khalil Shereen , Farid Hoda , Sabry Nouran , Yehia Mariam 
Published: October 2023

Abstract
Background
Telemedicine has a great role in delivering clinical services when distance and time are critical factors. Although this tool does not replace a medical examination, it was inevitably needed service during COVID-19 pandemic as it avoided the need for a patient’s visit, particularly at times when confinement measures are being enforced. As technology is sweeping the earth, the role of telemedicine should be evaluated precisely as an ongoing service with great emphasis on patient’s satisfaction.

Patients and methods
Participants of telepsychiatric services using Ain Shams University platform for three consecutive months (July, August, and September 2021) were enrolled in the study. Data were collected using Google form, and patients were approached via telephone calls. De novo questionnaire for assessing patient’s satisfaction was conducted in Arabic to assess patient satisfaction.

Results
A total of 104 participants receiving video consultation. Positive attitude towards remote consultations was concluded, where 80.8% (84) of the patients were satisfied from telepsychiatry services.

Conclusion
Our study highlights high degree of satisfaction among patients receiving telepsychiatry consultations provided by Okasha Institute of Psychiatry, Ain Shams University, Egypt.
The complexities in diagnosing intradiaphragmatic extrapulmonary sequestration: a case report
Authors: Ramos Anna-Kaelle K. J. , Teramae Tori R. , Liang Collin G. Z. , Brazer Miriam L. , Woo Russell K. 
Published: October 2023

Abstract
Background
Extralobar pulmonary sequestration–a congenital lung malformation characterized by nonfunctional lung tissue with its own visceral pleura and without a connection to the normal tracheobronchial tree–is often surgically resected given the potential for infectious complications. We report a case of a child with extralobar pulmonary sequestration in a rare and challenging intradiaphragmatic location, which made preoperative identification and planning difficult.

Case presentation
A 2-year-old boy presented for follow-up of a large left extralobar pulmonary sequestration initially diagnosed on an antenatal ultrasound. Follow-up imaging, including prenatal MRI and postnatal CT angiography, was inconclusive on the precise location of the extralobar pulmonary sequestration in relation to the diaphragm but did reveal a subdiaphragmatic arterial supply from a branch off the celiac trunk. Planned resection with diagnostic thoracoscopy revealed the mass to seemingly be below the diaphragm; however, subsequent abdominal laparoscopy identified it to be within the diaphragm. Once the supplying vessel off the celiac trunk was controlled and divided, the mass was circumferentially excised from the edges of the diaphragmatic muscle. The remaining diaphragmatic defect was then closed, and the patient did well postoperatively.

Conclusions
This case demonstrates the difficulty of making a definitive diagnosis of intradiaphragmatic extralobar pulmonary sequestration without operative intervention. CT angiography and identification of the sequestration’s arterial supply may not be conclusive in determining the precise location if in close proximity to the diaphragm.
Prognostic Impact of Mesenteric Lymph Node Status on Digestive Resection Specimens During Cytoreductive Surgery for Ovarian Peritoneal Metastases
Authors: Channawi Ali , Pop Florin-Catalin , Khaled Charif , Gomez Maria Galdon , Moreau Michel , Polastro Laura , Veys Isabelle , Liberale Gabriel 
Published: October 2023

Abstract
Background
The most common mode of ovarian cancer (OC) spread is intraperitoneal dissemination, with the peritoneum as the primary site of metastasis. Cytoreductive surgery (CRS) with chemotherapy is the primary treatment. When necessary, a digestive resection can be performed, but the role of mesenteric lymph nodes (MLNs) in advanced OC remains unclear, and its significance in treatment and follow-up evaluation remains to be determined. This study aimed to evaluate the prevalence of MLN involvement in patients who underwent digestive resection for OC peritoneal metastases (PM) and to investigate its potential prognostic value.

Methods
This retrospective, descriptive study included patients who underwent CRS with curative intent for OC with PM between 1 January 2007 and 31 December 2020. The study assessed MLN status and other clinicopathologic features to determine their prognostic value in relation to overall survival (OS) and progression-free survival (PFS).

Results
The study enrolled 159 women with advanced OC, 77 (48.4%) of whom had a digestive resection. For 61.1% of the patients who underwent digestive resection, MLNs were examined and found to be positive in 56.8%. No statistically significant associations were found between MLN status and OS (p = 0.497) or PFS ((p = 0.659).

Conclusions
In anatomopathologic studies, MLNs are not systematically investigated but are frequently involved. In the current study, no statistically significant associations were found between MLN status and OS or PFS. Further prospective studies with a systematic and standardized approach should be performed to confirm these findings.
Estimasi Cadangan Karbon Pada Ekosistem Mangrove Di Desa Pengudang Kecamatan Teluk Sebong Kabupaten Bintan
Authors: Alviana Diah , Anggraini Rika , Hidayati Jelita Rahma , Karlina Ita , Lestari Febrianti , Apdillah Dony , Syakti Agung Dhamar , Sihite Dermawati 
Published: October 2023

Mangrove have a role in the absorption and storage of carbon from the atmosphere, which is stored in the form of biomass and sediment, so that mangroves have enormous potential in mitigation global climate change because they can reduce greenhouse gas emission is carbon. Mangrove store carbon in carbon pools including above ground biomass, below ground biomass, litter or dead wood, and soil. The purpose of this study was to calculate the value of carbon stock and carbon sequestration in mangroves in Pengudang Villages, Teluk Sebong District, Bintan Regency. This research was conducted in September – October 2022, the research method used purposive sampling non-destructive method with allometric model and sediment sampling was carried out at 30 cm intervals until the discovery of humus soil. The result of biomass calculations were then converted into carbon stock values and mangrove carbon sequestration. Data analysis was carried out by calculating biomass, carbon stock value and carbon sequestration in mangroves in Pengudang Villages, Teluk Sebong District, Bintan Regency. The result showed the total biomass value was 498,77 tons/ha, the carbon stock value was 1203,27 tonsC/ha, while the carbon sequestration value was 4412,05 tonsC/ha. Mangrove berperan dalam penyerapan dan penyimpanan karbon dari atmosfer yang disimpan dalam bentuk biomassa dan sedimen, sehingga mangrove memiliki potensi yang sangat besar dalam mitigasi perubahan iklim global karena dapat mengurangi emisi gas rumah kaca yaitu karbon. Mangrove menyimpan karbon dalam kantong karbon diantaranya adalah biomassa bagian atas, biomassa bagian bawah, serasah atau kayu mati dan tanah. Tujuan penelitian ini untuk menghitung nilai stok karbon dan sekuestrasi karbon pada mangrove di Desa Pengudang Kecamatan Teluk Sebong Kabupaten Bintan. Penelitian ini dilakukan pada bulan September – Oktober tahun 2022, metode penelitian yang digunakan adalah purposive sampling metode non-destruktif dengan model alometrik dan dilakukan pengambilan sampel sedimen per-interval 30cm hingga ditemukannya tanah humus. Hasil perhitungan biomassa kemudian dilakukan konversi nilai stok karbon dan sekuestrasi karbon mangrove. Analisis data dilakukan dengan menghitung biomassa, nilai stok karbon dan sekuestrasi karbon pada mangrove di Desa Pengudang Kecamatan Teluk Sebong Kabupaten Bintan. Hasil penelitian menunjukkan nilai total biomassa 498,77 ton/ha nilai stok karbon adalah 1203,27 tonC/ha sedangkan nilai sekuestrasi karbon adalah 4412,05 tonC/ha.
Catatan Pertama Distribusi Tridacna noae (Röding, 1798) dari Perairan Kepulauan Kei, Maluku
Authors: Triandiza Teddy , Hernawan Udhi Eko , Kusnadi Agus 
Published: October 2023

The giant clams are the biggest living bivalves that not only play a vital role in coral reef ecosystem, but also as a food provider for coastal inhabitant. One of these species was Tridacna noae which is a crpyctic species due to morphoplogial characteristic similarity and habitat preferences with Tridacna maxima. Tridacna noae was recorded at the first time found in Kei Islands on November and December 2017 based on morphological characteristic and DNA barcoding analysis. This research found 8 individu of T. Noae in total, 7 individu was found in Kur Island and one individu from Ohoidertom at 2-3 m depth. The mantle pattern of T. noae was very unique and can be used to distinguished from T. maxima. Special feature of ormanent mantle of T. noae indicated with oval-shape patch with white line on the edge, has hyaline organ scattered along the margin of mantle and the presence of papillae that clearly seen. The result on Blasting from GenBank NCBI for COI sequence of giant clam sample revealed that 99.79%-100% was identical with T. noae species. Furthermore, result on genetic distance analysis of T. noae sample from Kei Island compare with T.noae from GenBank was 0.00-0.051, while genetic distance value compare with T. maxima was 0.159 – 0.205. The new finding of T. noae in Kei Island has added the number of giant clam species recorded previously become 7 species. This finding was also has enhanced the information on biogeographical distribution of T.noae in Indonesia. Kerang kima merupakan kelompok bivalvia berukuran paling besar yang memlilki peranan penting di ekosistem terumbu karang serta menjadi sumber nutrisi bagi masyarakat peisir. Salah satu species kima adalah Tridacna noae yang bersifat cryptic spesies karena memiliki banyak kesamaan karakteristik morfologi dan preferensi habitat dengan T. Maxima. T. noae tercatat pertama kali ditemukan di Perairan Kepulauan Kei pada bulan November dan Desember 2017 berdasarkan pengamatan karekteristik morfologi dan aplikasi DNA barcoding. Hasil peneltian menemukan delapan individu T. noae, tujuh individu ditemukan di Perairan Pulau Kur, satu individu ditemukan di Perairan Ohoidertoom dengan kedalaman perairan 2-3 m. Ornamen mantel T. noae sangat khas dan dapat digunakan untuk membedakan dari T. maxima. Ornamen mantel ditandai dengan patch berbentuk oval terpisah dengan garis putih di tepi, memiliki organ hialin yang tersebar di sepanjang margin mantel, dan kehadiran papila yang terlihat jelas. Hasil blasting di GenBank NCBI untuk sekuens COI sampel kima menghasilkan tingkat kemiripan 99.79%-100% (identik) dengan T. noae. Hasil analisis jarak genetik sampel T. noae asal Kepulauan Kei dengan T. noae Genbank adalah sebesar 0.00 hingga 0.051, sedangkan jarak genetik dengan T. maxima adalah 0.159 hingga 0.205. Temuan T. noae di Kepulauan Kei menambahkan jenis kima yang tercatat sebelumnya di Kepulauan Kei menjadi 7 jenis. Temuan ini juga menambahkan lebih banyak informasi tentang distribusi geografis T. noae di Indonesia
RNA/DNA Ratio Performance of Blue Swimming Crab (Portunus pelagicus) Fed with Natural Food Phronima sp. and Artemia salina in Juvenile Phase
Authors: Mulyani Sri , Indrawati Erni , Bahri Syamsul 
Published: October 2023

The availability and quality of fry is a major problem in blue swimming crab aquaculture, with the high mortality at the larval stage. RNA/DNA ratio is one of the parameters that can be used to evaluate the quality of crab fry, including health, nutrition, and growth conditions. This study aims to analyze the effect of Phronima sp. as a substitute feed for Artemia salina on the RNA/DNA ratio performance of blue swimming crab in juvenile phase (crablet 5) during rearing before cultivation in aquaculture ponds. This research was conducted at the Crab Hatchery Unit of the Brackish Water Aquaculture Fisheries Center (BPBAP) Takalar in February 2023. The study used a quantitative experimental completely randomized design (CRD) with five treatments and three repetitions. The ratio of Phronima sp. and Artemia sp. used were: Treatment A 100% Phronima sp; Treatment B 100% Artemia sp; Treatment C 75% Phronima sp and 25% Artemia sp; Treatment D 25% Phronima sp and 75% Artemia sp.; and E: Phronima 75%+Artemia salina 25%. The results showed that Artemia salina combined with Phronima sp. increased the RNA/DNA ratio of the crab compared to a single feed (100% Phronima sp. or Artemia salina 100%). The feed combination with the highest RNA/DNA ratio was shown in treatment E (Phronima sp. 25% + Artemia salina 75%) with an RNA/DNA ratio of 2.02 +0.032 ng/µL.