bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus
Authors: Yasaka Ken , Yamazaki Tomohide , Sato Hiroko , Shirai Tsuyoshi , Cho Minkwon , Ishida Koji , Ito Koyu , Tanaka Tetsuhiro , Ogasawara Kouetsu , Harigae Hideo , Ishii Tomonori , Fujii Hiroshi 
Published: October 2023

Abstract
Background
In systemic lupus erythematosus (SLE), autoreactive B cells are thought to develop by-passing immune checkpoints and contribute to its pathogenesis. Toll-like receptor (TLR) 7 and 9 signaling have been implicated in their development and differentiation. Although some B cell subpopulations such as T-bet + double negative 2 (DN2) cells have been identified as autoreactive in the past few years, because the upregulated surface markers of those cells are not exclusive to them, it is still challenging to specifically target autoreactive B cells in SLE patients.

Methods
Our preliminary expression analysis revealed that phospholipase D4 (PLD4) is exclusively expressed in plasmacytoid dendritic cells (pDCs) and B cells in peripheral blood mononuclear cells (PBMCs) samples. Monoclonal antibodies against human PLD4 were generated, and flow cytometry analyses were conducted for PBMCs from 23 healthy donors (HDs) and 40 patients with SLE. In vitro cell culture was also performed to study the conditions that induce PLD4 in B cells from HDs. Finally, recombinant antibodies were synthesized from subpopulations of PLD4 + B cells from a patient with SLE, and their antinuclear activity was measured through enzyme-linked immunosorbent assay.

Results
pDCs from both groups showed comparable frequency of surface PLD4 expression. PLD4 + B cells accounted for only a few percent of HD B cells, whereas they were significantly expanded in patients with SLE (2.1% ± 0.4% vs. 10.8% ± 1.2%, P < 0.005). A subpopulation within PLD4 + B cells whose cell size was comparable to CD38 + CD43 + plasmablasts was defined as “PLD4 + blasts,” and their frequencies were significantly correlated with those of plasmablasts (P < 0.005). PLD4 + blasts phenotypically overlapped with double negative 2 (DN2) cells, and, in line with this, their frequencies were significantly correlated with several clinical markers of SLE. In vitro assay using healthy PBMCs demonstrated that TLR7 or TLR9 stimulation was sufficient to induce PLD4 on the surface of the B cells. Finally, two out of three recombinant antibodies synthesized from PLD4 + blasts showed antinuclear activity.

Conclusion
PLD4 + B cells, especially “blastic” ones, are likely autoreactive B cells undergoing TLR stimulation. Therefore, PLD4 is a promising target marker in SLE treatment.
Antimicrobial peptides modulate lung injury by altering the intestinal microbiota
Authors: Abdelgawad Ahmed , Nicola Teodora , Martin Isaac , Halloran Brian A. , Tanaka Kosuke , Adegboye Comfort Y. , Jain Pankaj , Ren Changchun , Lal Charitharth V. , Ambalavanan Namasivayam , O’Connell Amy E. , Jilling Tamás , Willis Kent A. 
Published: October 2023

Abstract
Background
Mammalian mucosal barriers secrete antimicrobial peptides (AMPs) as critical, host-derived regulators of the microbiota. However, mechanisms that support microbiota homeostasis in response to inflammatory stimuli, such as supraphysiologic oxygen, remain unclear.

Results
We show that supraphysiologic oxygen exposure to neonatal mice, or direct exposure of intestinal organoids to supraphysiologic oxygen, suppresses the intestinal expression of AMPs and alters intestinal microbiota composition. Oral supplementation of the prototypical AMP lysozyme to hyperoxia-exposed neonatal mice reduced hyperoxia-induced alterations in their microbiota and was associated with decreased lung injury.

Conclusions
Our results identify a gut-lung axis driven by intestinal AMP expression and mediated by the intestinal microbiota that is linked to lung injury in newborns. Together, these data support that intestinal AMPs modulate lung injury and repair.
Exploring the effect of mobile-assisted task-based learning on vocabulary achievement and student attitude
Authors: Jedi-Sari-Biglar Leila , Liman-Kaban Aysegül 
Published: October 2023

AbstractThis study explores the effect of mobile-assisted task-based learning (M-TBL) on vocabulary achievement and student attitude among English as a in content and language integrated learning (CLIL) science lessons, the researcher focused on foreign language (FL) students. To investigate this, a quasi-experimental research design was utilized. In the first semester of the 2022–2023 academic year, 34 fourth-grade students from a private school in Istanbul took part in the study. During the course of 6 weeks, the experimental group engaged in six different M-TBL activities and were assigned a one-page worksheet as homework, while the control group completed only the one-page worksheet. Quantitative data for the study were collected through vocabulary achievement tests and a student attitude questionnaire. The data underwent analysis through paired sample t-tests and descriptive analyses. The results indicated a significant difference in vocabulary achievement between the experimental and control groups, and they also revealed a positive impact on student attitudes, igniting their interest in learning the target language. In light of these findings, it can be concluded that mobile-assisted task-based activities yield positive effects on both vocabulary achievement and student attitude in primary FL learners participating in CLIL science lessons.
Rehabilitation after lumbar spine surgery in adults: a systematic review with meta-analysis
Authors: Manni Tiziana , Ferri Nicola , Vanti Carla , Ferrari Silvano , Cuoghi Ilaria , Gaeta Claudia , Sgaravatti Isabella , Pillastrini Paolo 
Published: October 2023

Abstract
Background
The role of rehabilitation after surgery in patients with low back pain is well recognized. The aim of this systematic review is to summarize and update the existing evidence according to the type of clinical condition and rehabilitation approach.

Methods
This systematic review included RCTs on the effectiveness of rehabilitation after surgery for lumbar disc herniation, spinal stenosis, and spondylolisthesis. We searched the literature for randomized controlled trials indexed in MEDLINE, Embase, CINHAL, CENTRAL, Scopus, PEDro, and Web of Science databases, up to April 15, 2023. We used Cochrane Risk of Bias 2.0 tool to assess each study. We conducted a quantitative synthesis when population, intervention, control, and outcome were sufficiently homogeneous; otherwise, we conducted a qualitative analysis.

Results
Forty-five studies (3.036 subjects) were included and analyzed according to the population considered: lumbar stenosis (1 trial), spondylolisthesis (3 trials), and disc herniation (41 trials). Regarding lumbar stenosis, a supervised active exercise program appears to improve outcomes related to pain, disability, and quality of life both in the short- and mid-term (1 study, n = 60). Concerning spondylolisthesis, kinesiophobia is reduced in the home exercises group compared to usual care, at 3-months follow-up (3 studies, n = 98). For disk herniation, supervised exercises are better than non-supervised exercises to reduce pain (MD -1.14; 95% CIs -1.65, -0.62; 5 trials, n = 250) and disability (SMD -0.70; 95% CIs -1.14, -0.26; 4 trials, n = 175). Supervised exercises are better than advice in reducing pain (SMD -0.91; 95% CIs -1.61, -0.21; 5 trials, n = 341) and disability (SMD -0.80; 95% CIs -1.59, -0.01; 4 trials, n = 261), in the short-term. Supervised exercises are equal to no treatment in reducing pain and disability, at 3 and 6 months after intervention (2 trials, n = 166). These results are supported by a very low to low quality of evidence.

Conclusions
Our research suggests that supervised exercise may be effective in improving patient’s pain and disability after lumbar surgery, but RCTs regarding lumbar spinal stenosis and lumbar spondylolisthesis are still scarce, with significant heterogeneity of proposed interventions.
Synergistically enhancing hydrogen bonding, hydrophobic interaction and electrostatic association of collagen fiber to flavonoid aglycones for their effective separation by polyethyleneimine modification
Authors: Zhang Qixian , Wang Rui , Shi Bi 
Published: October 2023

AbstractCompared with flavonoid glycosides, flavonoid aglycones are difficult to be separated since they have less hydroxyls. Collagen fiber (CF), a natural polymer, was once used as packing material for separation of kaempferol and quercetin (the typical flavonoid aglycones) after crosslinking by glutaraldehyde mainly based on hydrogen bonding and hydrophobic interaction in column length-diameter ratio of 60:1. Hydrophobic modification by grafting alkyl chains was then employed to enhance the hydrophobic interaction between CF and flavonoid aglycones, which can improve the separation efficiency and decrease column length-diameter ratio to 19:1. In order to further improve the adsorption capacity and separation efficiency, the strategy of simultaneously grafting hydrophobic alkyl chains (–CH2–CH2–) and alkali groups (–NH2) was adopted in this work to enhance hydrophobic interaction, hydrogen bonding and electrostatic association to flavonoid aglycones at the same time through grafting polyethyleneimine (PEI). PEI modified CF (PEI-CF) maintained the fiber structure of CF, and had higher adsorption extent and rate to flavonoid aglycones through the enhanced synergetic effect of hydrophobic interaction, hydrogen bonding and electrostatic association. As a result, PEI-CF presented a satisfactory column separation efficiency for kaempferol and quercetin even the length-diameter ratio of column was decreased to 11:1, which was much better than previously developed glutaradehyde-crosslinked collagen fiber and isobutyl-grafted collagen fiber, as well as commonly used polyamide and Sephadex LH-20.
Graphical abstract
A double sideband combined tracking method for Galileo E5 AltBOC signals
Authors: Fan Tongwen , Zhang Tisheng , Zhang Hongping , Mo Jun , Niu Xiaoji 
Published: October 2023

AbstractThe Galileo navigation satellite system (Galileo) E5 Alternative Binary Offset Carrier (AltBOC) signal brings various challenges due to its complex modulation, wide bandwidth, and multi-peaked auto-correlation function. While wideband tracking needs to solve the ambiguity problem and design dedicated baseband channels, the single-sideband cannot have the outstanding performance of the AltBOC signal. We propose a new tracking method called “Double Sideband Combined Tracking” (DSCT), which can fully exploit the AltBOC signal’s code tracking accuracy without ambiguity and ensure compatibility with Binary Phase Shift Keying (BPSK) processing channels, easily implemented in hardware. The DSCT employs one phase locked loop and one delay locked loop to track the carrier and code, respectively. The double-sideband correlation results used by the two loops are recovered by coherently combining the single-sideband correlation results of the two BPSK channels. Meanwhile, the combined model, the loop discriminator, and the ambiguity detection of the DSCT are discussed. Furthermore, the code tracking error caused by thermal noise is modeled and analyzed. The test results based on real Galileo E5 signals show that the DSCT exhibits better or comparable code tracking accuracy to the AltBOC wideband tracking method. When the loop falsely locks onto a side-peak, the DSCT can quickly detect and re-lock on the main peak.
Influence of visual perception on movement decisions by an ungulate prey species
Authors: Newman Blaise A. , Dyal Jordan R. , Miller Karl V. , Cherry Michael J. , D'Angelo Gino J. 
Published: October 2023

ABSTRACT
Visual perception is dynamic and depends on physiological properties of a species’ visual system and physical characteristics of the environment. White-tailed deer (Odocoileus virginianus) are most sensitive to short- and mid-wavelength light (e.g. blue and green). Wavelength enrichment varies spatially and temporally across the landscape. We assessed how the visual perception of deer influences their movement decisions. From August to September 2019, we recorded 10-min locations from 15 GPS-collared adult male deer in Central Florida. We used Hidden-Markov models to identify periods of movement by deer and subset these data into three time periods based on temporal changes in light environments. We modeled resource selection during movement using path-selection functions and simulated 10 available paths for every path used. We developed five a priori models and used 10-fold cross validation to assess our top model's performance for each time period. During the day, deer selected to move through woodland shade, avoided forest shade, and neither selected nor avoided small gaps. At twilight, deer avoided wetlands as cloud cover increased but neither selected nor avoided other cover types. Visual cues and signals are likely more conspicuous to deer in short-wavelength-enriched woodland shade during the day, while at twilight in long-wavelength-enriched wetlands during cloud cover, visual cues are likely less conspicuous. The nocturnal light environment did not influence resource selection and likely has little effect on deer movements because it's relatively homogenous. Our findings suggest visual perception relative to light environments is likely an underappreciated driver of behaviors and decision-making by an ungulate prey species.
An interactive resource of molecular signalling in the developing human haematopoietic stem cell niche
Authors: Crosse Edie I. , Binagui-Casas Anahi , Gordon-Keylock Sabrina , Rybtsov Stanislav , Tamagno Sara , Olofsson Didrik , Anderson Richard A. , Medvinsky Alexander 
Published: October 2023

ABSTRACT
The emergence of definitive human haematopoietic stem cells (HSCs) from Carnegie Stage (CS) 14 to CS17 in the aorta-gonad-mesonephros (AGM) region is a tightly regulated process. Previously, we conducted spatial transcriptomic analysis of the human AGM region at the end of this period (CS16/CS17) and identified secreted factors involved in HSC development. Here, we extend our analysis to investigate the progression of dorso-ventral polarised signalling around the dorsal aorta over the entire period of HSC emergence. Our results reveal a dramatic increase in ventral signalling complexity from the CS13-CS14 transition, coinciding with the first appearance of definitive HSCs. We further observe stage-specific changes in signalling up to CS17, which may underpin the step-wise maturation of HSCs described in the mouse model. The data-rich resource is also presented in an online interface enabling in silico analysis of molecular interactions between spatially defined domains of the AGM region. This resource will be of particular interest for researchers studying mechanisms underlying human HSC development as well as those developing in vitro methods for the generation of clinically relevant HSCs from pluripotent stem cells.
HEXOKINASE1 and glucose-6-phosphate fuel plant growth and development
Authors: Vanderwall Morgan , Gendron Joshua M. 
Published: October 2023

ABSTRACT
As photoautotrophic organisms, plants produce an incredible spectrum of pigments, anti-herbivory compounds, structural materials and energic intermediates. These biosynthetic routes help plants grow, reproduce and mitigate stress. HEXOKINASE1 (HXK1), a metabolic enzyme and glucose sensor, catalyzes the phosphorylation of hexoses, a key introductory step for many of these pathways. However, previous studies have largely focused on the glucose sensing and signaling functions of HXK1, and the importance of the enzyme's catalytic function is only recently being connected to plant development. In this brief Spotlight, we describe the developmental significance of plant HXK1 and its role in plant metabolic pathways, specifically in glucose-6-phosphate production. Furthermore, we describe the emerging connections between metabolism and development and suggest that HXK1 signaling and catalytic activity regulate discrete areas of plant development.
Case Report: Solid pseudo-papillary tumor of the pancreas
Authors: Ghanney Olfa , Saad Rim , Ben A mor soumaya , Mayada Trimech 
Published: October 2023

Solid pseudo-papillary tumors (SPT) of the pancreas are rare neoplasms accounting for less than 2% of all pancreatic tumors and primarily affecting young women. They are generally characterized by a clinical and radiological polymorphism. In most cases, complete surgical resection is curative. We report a case of a young woman presenting with a pancreatic tumor revealed through a vague non-specific abdominal pain. The diagnosis was based on the histological examination of the surgically-removed piece.
Bibliometric analysis of scientific production on university social responsibility in Latin America and the Caribbean
Authors: Urrunaga-Pastor Diego , Bendezu-Quispe Guido , Dávila-Altamirano Deici , Asmat Milagritos N. , Grau-Monge Jordi 
Published: October 2023

Objective: To evaluate the scientific production on university social responsibility (USR) from institutions in Latin America and the Caribbean. Methods: A bibliometric analysis was conducted on documents published in indexed journals in the Scopus database from its inception until April 2023. Eligible documents included those on USR describing experiences carried out by universities in Latin America and the Caribbean. The number of articles per author, average authors per article, average citations per article, and the number of documents with one or more author were described. Bibliometric indicators regarding authors per article, co-authors per article, and institutional collaboration were presented. Bibliometric networks were constructed based on bibliographic coupling analysis of documents by countries and term co-occurrence in titles and abstracts. Results: Of a total of 4075 documents retrieved from Scopus, 150 were included. Documents published between 1997 and 2023 were identified, with an average annual growth rate of 2.7%. A total of 439 authors were identified, 18 articles had a single author, and an average of 0.3 articles per author and a co-authorship index of 3.13 were found. The percentage of international collaborations was 30.7%. Brazil had the highest proportion of publications (26.4%), followed by Chile (17%) and Colombia (13.2%). Opción and Revista de Ciencias Sociales were the journals with the highest number of articles published (13 each). In the analysis of term co-occurrence, recent years showed an increase in the use of terms related to e-learning, information and communication technologies, virtual education, COVID-19, sustainable development goals, and URSULA (initiative on USR in institutions in Latin America and the Caribbean). Conclusions: A growth in scientific production on USR in Latin America and the Caribbean was identified. The interest in USR documents in recent years has been focused on COVID-19 and the challenges of virtual education and sustainable development.
Polska grzeczność językowa – dawniej i dziś
Authors: Sikora Kazimierz 
Published: October 2023

Polska grzeczność językowa – dawniej i dziś
Tekst omawia najważniejsze zmiany w polskiej etykiecie językowej, dokonujące się głównie za sprawą zwyczajów językowych młodego pokolenia Polek i Polaków. Autor konfrontuje je z tzw. tradycyjną polską grzecznością językową i wskazuje na fundamentalną zmianę w modelu grzeczności, polegającą na zmianie orientacji: z nastawienia na TY (na rozmówcę) na nastawienie na JA (na nadawcę). Wśród najważniejszych czynników zmian wymienia i omawia egalitaryzm grzecznościowy i dążenie do skracania dystansu pomiędzy uczestnikami komunikacji, przyspieszenie cywilizacyjne, kult młodości, emancypację kobiet i ogólną amerykanizację (makdonaldyzację) stylu życia – powiązaną z wpływami postmodernizmu.
O dwóch pobytach Stanisława Wyspiańskiego na Łemkowszczyźnie
Authors: Łopatkiewicz Tadeusz 
Published: October 2023

O dwóch pobytach Stanisława Wyspiańskiego na Łemkowszczyźnie
Twórczość Stanisława Wyspiańskiego tradycyjnie wiązana jest z Młodą Polską, przynależąc aksjologicznie do świata kultury zachodniej oraz chrześcijaństwa łacińskiego. Mimo to Artysta od wczesnej młodości żywo interesował się Kresami Rzeczypospolitej, a także kulturą artystyczną chrześcijaństwa wschodniego. Znajomość tej problematyki przyniosła Wyspiańskiemu indywidualna wycieczka do Lwowa i okolic, którą odbył w sierpniu 1887 roku. W dwa lata później, nieoczekiwanie i raczej przypadkowo, Artysta, wraz z Józefem Mehofferem, znalazł się w łemkowskiej wsi Królowa Ruska (dzisiaj Królowa Górna), gdzie w ciągu dwudniowego pobytu rysunkowo i opisowo zinwentaryzował siedemnastowieczne wyposażenie artystyczne wnętrza miejscowej cerkwi, ponadto odbył naradę z Łemkami oraz księdzem greckokatolickim na temat projektu nowego ikonostasu do świątyni.
Drugi z pobytów Wyspiańskiego na Łemkowszczyźnie miał miejsce w lecie 1901 roku, kiedy to Artysta wraz z rodziną mieszkał przez pięć tygodni w łemkowskim Desznie, opodal Rymanowa-Zdroju, w nieistniejącym dziś domu dla kuracjuszy. Badania terenowe, które przeprowadził autor artykułu, pozwoliły nie tylko zweryfikować dotychczasowe domysły w kwestii miejsca, gdzie Wyspiańscy zamieszkiwali w 1901 roku, ale też zebrać przekonujący materiał faktograficzny, na podstawie którego można dziś o tych kwestiach wnioskować w sposób pewny.
Pułapki dosłownego tłumaczenia rosyjskiego wykrzyknika Ба! Na przykładach z „Mistrza i Małgorzaty” oraz innych dzieł literackich
Authors: Styrcz-Przebinda Leokadia 
Published: October 2023

Pułapki dosłownego tłumaczenia rosyjskiego wykrzyknika Ба! Na przykładach z „Mistrza i Małgorzaty” oraz innych dzieł literackich
Tekst dotyczy problemu przekładu wykrzykników i adekwatności przekazu komunikowanych przez nie emocji. Liczne cytaty, egzemplifikujące znaczenie rosyjskiego słowa Ба!, w oryginale dotyczą zdziwienia, zaskoczenia na widok kogoś/czegoś, w szczególności przy nieoczekiwanym spotkaniu. Dosłowne tłumaczenie w takich sytuacjach jest w polszczyźnie nieuzasadnione, ponieważ polska równobrzmiąca jednostka ba – nietożsama z rosyjską – funkcjonuje inaczej. Zalicza się ona do kategorii komentarza metatekstowego, dopowiedzeń, odnoszących się zawsze do treści wcześniejszego kontekstu.
„To co złe, przepowiadam bezbłędnie”. Wywiad z Dmitrijem Bykowem (Kraków, październik 2019)
Authors: Przebinda Grzegorz 
Published: October 2023

„To co złe, przepowiadam bezbłędnie”. Wywiad z Dmitrijem Bykowem (Kraków, październik 2019)
Rozmowa z bardzo znanym pisarzem rosyjskim średniego pokolenia Dmitrijem Bykowem (ur. w 1967), obecnie na emigracji w USA, przeprowadzona w Krakowie w październiku 2019 roku. Dotyczy wielojęzyczności pisarzy różnych narodowości na emigracji, niereformowalności Rosji putinowskiej oraz zakresu wpływu kultury polskiej na twórczość samego Bykowa. Ważny fragment wywiadu dotyczy rosyjskich pisarzy, będących w niewoli niemieckiej podczas II wojny (Witalij Siomin, Konstanin Worobiow) oraz wstrząsającej dokumentalnej opowieści Elżunia autorstwa Iriny Irosznikowej – o polskiej dziewczynce zamordowanej przez żołnierza niemieckiego, z takim wstrząsającym mottem: „„Była sobie raz Elżunia, umierała sama / Bo jej ojciec w Oświęcimiu / Na Majdanku mama”.