bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of transvenous embolization of CSF-venous fistula in spontaneous intracranial hypotension: Case-series
Authors: Ellens Nathaniel R. , Schartz Derrek , Ismail Rahim , Kessler Alex , Ellika Shehenaz , Akkipeddi Sajal Medha K. , Rahmani Redi , Bender Matthew T. 
Published: December 2023

Background Spontaneous intracranial hypotension is a debilitating neurological condition which can be caused by a cerebrospinal fluid-venous fistula. Transvenous embolization is a promising technique to provide minimally invasive yet durable treatment. Methods A retrospective single-center case series was performed on all patients who underwent transvenous embolization of a cerebrospinal fluid (CSF)-venous fistula. Clinical and radiographic parameters, including Bern score, were reported preoperatively and at 3-month follow-up. Results Six patients underwent embolization of a CSF-venous fistula. All fistulae were located in the thoracic spine and technical success was achieved in all cases. Three patients had symptom resolution, two had significant improvement, and one had stable symptoms on follow-up. The mean Bern score was 6.83 (SD = 1.47) preoperatively and 1.83 (SD = 1.64) postoperatively with a mean improvement in Bern score of 5.0 (SD = 1.9, p = 0.0013). Conclusions CSF-venous fistulas are an increasingly recognized clinical entity which may be treated with transvenous embolization. This case series serves to further validate this technique and suggests it can be performed with similar outcomes in lower volume centers.
Evaluation of brain metastasis edema in breast cancer patients as a marker for Ki-67 and cell count—A single center analysis
Authors: Stojkova Marija , Behme Daniel , Barajas Ordonez Felix , Christ Sebastian M , March Christine , Surov Alexey , Thormann Maximilian 
Published: December 2023

Background Peritumoral edema is an important cause of morbidity and mortality in patients with breast cancer brain metastases (BCBM). The relationship between vasogenic edema and proliferation indices or cell density in BCBM remains poorly understood. Purpose To assess the association between tumor volume and peritumoral edema volume and histopathological and immunohistochemical parameters in BCBM. Materials and Methods Patients with confirmed BCBM were retrospectively identified. The tumor volume and peritumoral edema volume of each brain metastasis (BM) were semi-automatically calculated in axial T2w and axial T2-fluid attenuated inversion recovery (FLAIR) sequences using the software MIM (Cleveland, Ohio, USA). Edema volume was correlated with histological parameters, including cell count and Ki-67. Sub-analyses were conducted for luminal B, Her2-positive, and tripe negative subgroups. Results Thirty-eight patients were included in the study. There were 24 patients with a single BM. Mean metastasis volume was 31.40 ± 32.52 mL and mean perifocal edema volume was 72.75 ± 58.85 mL. In the overall cohort, no correlation was found between tumor volume and Ki-67 (r = 0.046, p = .782) or cellularity (r = 0.028, p = .877). Correlation between edema volume and Ki-67 was r = 0.002 ( p = .989), correlation with cellularity was r = 0.137 ( p = .453). No relevant correlation was identified in any subgroup analysis. There was no relevant correlation between BM volume and edema volume. Conclusion In patients with breast cancer brain metastases, we did not find linear associations between edema volumes and immunohistochemical features reflecting proliferation potential. Furthermore, there was no relevant correlation between metastasis volume and edema volume.
Eradicate Helicobacter pylori first, or treat peptic ulcer disease?
Authors: He Xinjue , Li Lan , Lu Chao 
Published: December 2023

Background: Helicobacter pylori infection is very common worldwide, and about 10%–16% of these patients develop peptic ulcer disease. However, there is limited research on the impact of H. pylori eradication and peptic ulcer disease treatment sequencing. Methods: We conducted a retrospective study of adult patients diagnosed with H. pylori infection and peptic ulcer disease between October 2020 and April 2021 at our center. Data on primary treatment outcomes, including H. pylori eradication and peptic ulcer disease healing, were collected, and factors that may influence treatment outcomes were analyzed. Results: A total of 306 patients were included in this study. The sequence of H. pylori eradication and peptic ulcer disease treatment did not significantly affect the outcomes of H. pylori eradication and peptic ulcer disease healing. In addition, patient age, peptic ulcer disease type, clinic type and treatment regimen (including choice of proton pump inhibitor) had no significant impact on H. pylori eradication. However, patient gender and the choice of antibiotic combination proved to be key factors, as eradication rates were lower in female patients compared to males, and the combination of levofloxacin and clarithromycin was the least effective in eradicating H. pylori. Regarding peptic ulcer disease healing, the peptic ulcer disease type was an important influencing factor, since gastric ulcers being more likely to get cured completely compared to duodenal ulcers. Conclusions: The sequence of H. pylori eradication and peptic ulcer disease treatment does not significantly affect the primary outcomes. Patient gender and the choice of antibiotic combination are important factors in H. pylori eradication, whereas peptic ulcer disease type plays a key role in ulcer healing.
Biomechanical Evaluation of the 2 Different Levels of Coracoid Graft Positions in the Latarjet Procedure for Anterior Shoulder Instability
Authors: Ganokroj Phob , Dey Hazra Maria , Dey Hazra Rony-Orijit , Brady Alex W. , Brown Justin R. , Rupp Marco-Christopher , Garcia Alexander R. , Whalen Ryan J. , Millett Peter J. , Provencher Matthew T. 
Published: December 2023

Background: In the Latarjet procedure, the ideal placement of the coracoid graft in the medial-lateral position is flush with the anterior glenoid rim. However, the ideal position of the graft in the superior-inferior position (sagittal plane) for restoring glenohumeral joint stability is still controversial. Purpose: To compare coracoid graft clockface positions between the traditional 3 to 5 o'clock and a more inferior (for the right shoulder) 4 to 6 o'clock with regard to glenohumeral joint stability in the Latarjet procedure. Study Design: Controlled laboratory study. Methods: A total of 10 fresh-frozen cadaveric shoulders were tested in a dynamic, custom-built robotic shoulder model. Each shoulder was loaded with a 50-N compressive load while an 80-N force was applied in the anteroinferior axes at 90° of abduction and 60° of shoulder external rotation. Four conditions were tested: (1) intact, (2) 6-mm glenoid bone loss (GBL), (3) Latarjet procedure fixed at 3- to 5-o’clock position, and (4) Latarjet procedure fixed at 4- to 6-o’clock position. The stability ratio (SR) and degree of lateral humeral displacement (LHD) were recorded. A 1-factor random-intercepts linear mixed-effects model and Tukey method were used for statistical analysis. Results: Compared with the intact state (1.77 ± 0.11), the SR was significantly lower after creating a 6-mm GBL (1.14 ± 0.61, P = .009), with no significant difference in SR after Latarjet 3 to 5 o'clock (1.51 ± 0.70, P = .51) or 4 to 6 o'clock (1.55 ± 0.68, P = .52). Compared with the intact state (6.48 ± 2.24 mm), LHD decreased significantly after GBL (3.16 ± 1.56 mm, P < .001) and Latarjet 4 to 6 o'clock (5.48 ± 3.39 mm, P < .001). Displacement decreased significantly after Latarjet 3 to 5 o'clock (4.78 ± 2.50 mm, P = .04) compared with the intact state but not after Latarjet 4 to 6 o'clock ( P = .71). Conclusion: The Latarjet procedure in both coracoid graft positions (3-5 and 4-6 o’clock) restored the SR to the values measured in the intact state. A more inferior graft position (fixed at 4-6 o’clock) may improve shoulder biomechanics, but additional work is needed to establish clinical relevance. Clinical Relevance: An inferior coracoid graft fixation, the 4- to 6-o’clock position, may benefit in restoring normal shoulder biomechanics after the Latarjet procedure.
Arthroscopy Association of Canada Position Statement on Opioid Prescription After Arthroscopic Surgery
Authors: Nucci Nicholas , Degen Ryan , Ekhtiari Seper , Gazendam Aaron , Ayeni Olufemi R. , Horner Nolan , Wong Ivan , Woodmass Jarret , Grant John , Sheehan Brendan , Pickell Michael , Kopka Michaela , Martin Ryan , Tucker Allison , Sommerfeldt Mark , Gusnowski Eva , Rousseau-Saine Alexis , Lebel Marie-Eve , Karpyshyn Jillian , Matache Bogdan , Carroll Michael , Da Cunha Rachael , Kwapisz Adam , Martin R. Kyle , Khan Moin 
Published: December 2023

Background: Despite the ongoing opioid epidemic, most patients are still prescribed a significant number of opioid medications for pain management after arthroscopic surgery. There is a need for consensus among orthopaedic surgeons and solutions to aid providers in analgesic strategies that reduce the use of opioid pain medications. Purpose: This position statement was developed with a comprehensive systematic review and meta-analysis of exclusively randomized controlled trials (RCTs) to synthesize the best available evidence for managing acute postoperative pain after arthroscopic surgery. Study Design: Position statement. Methods: The Embase, MEDLINE, PubMed, Scopus, and Web of Science databases were searched from inception until August 10, 2022. Keywords included arthroscopy, opioids, analgesia, and pain, and associated variations. We included exclusively RCTs on adult patients to gather the best available evidence for managing acute postoperative pain after arthroscopic surgery. Patient characteristics, pain, and opioid data were extracted, data were analyzed, and trial bias was evaluated. Results: A total of 21 RCTs were identified related to the prescription of opioid-sparing pain medication after arthroscopic surgery. The following recommendations regarding noninvasive, postoperative pain management strategies were made: (1) multimodal oral nonopioid analgesic regimens—including at least 1 of acetaminophen—a nonsteroidal anti-inflammatory drug—can significantly reduce opioid consumption with no change in pain scores; (2) cryotherapy is likely to help with pain management, although the evidence on the optimal method of application (continuous-flow vs ice pack application) is unclear; (3) and (4) limited RCT evidence supports the efficacy of transcutaneous electrical nerve stimulation and relaxation exercises in reducing opioid consumption after arthroscopy; and (5) limited RCT evidence exists against the efficacy of transdermal lidocaine patches in reducing opioid consumption. Conclusion: A range of nonopioid strategies exist that can reduce postarthroscopic procedural opioid consumption with equivalent vocal pain outcomes. Optimal strategies include multimodal analgesia with education and restricted/reduced opioid prescription.
The Impact of Short Intensive Care Rotation on Residents’ Experience in the COVID-19 Pandemic: A Mixed-Methods Study
Authors: Khan Muhammad F. , Aziz Ayesha , Riaz Qamar , Ghaffar Waleed B. , Khan Fiza , Latif Asad 
Published: December 2023

Objectives To assess the impact and utility of an intensive care unit (ICU) rotation during the coronavirus disease 2019 (COVID-19) pandemic and the need for mandatory ICU rotations in training for all clinical specialties. Methods A mixed methods study was conducted from January to September 2021 at the Aga Khan University Hospital, including resident doctors who rotated through COVID ICU between May and September 2020. An online survey was undertaken, followed by two focused group discussions (FGDs). Results Fifty-nine complete responses out of a total of 86 were analyzed. Around 42.3% (n = 25) of doctors belonged to medicine/allied specialties and 57.6% (n = 34) had previous ICU experience. Both groups, with and without prior ICU experience, found the rotation equally challenging (82.3% (n = 28) versus 84% (n = 21), P = .776) and gained similar practical skills (35.3% (n = 12) versus 16% (n = 4), P = .072), however, those with experience gained significantly more knowledge (58.5% (n = 20) versus 32% (n = 8), P = .047). On opinion regarding mandatory ICU rotation, the majority agreed to have a mandatory rotation (82% (n = 28) versus 72% (n = 18), P = .421)) with an optimal duration of 1 to 2 months. The FGDs found that all residents encouraged the idea of mandatory training in ICU which must be tailored to their training specialty and suggested extending the duration beyond 1 week to ensure learning. Conclusions COVID ICU rotation was a good avenue for learning and the idea of mandatory ICU training was supported. Mandating ICU rotation might theoretically enhance response to emergencies. More research is needed to understand for feasible incorporation of ICU training in the curriculum.
The development of an advanced diploma program for palliative care leaders in Chile
Authors: Stoltenberg Mark , Leiva-Vásquez Ofelia , Pérez-Cruz Pedro E. , Daubman Bethany-Rose 
Published: December 2023

Context: The majority of people with serious health-related suffering in low- and middle-income countries lack access to palliative care (PC). Increased access to PC education is greatly needed. Objectives: This paper describes the process to adapt an advanced PC training course for a Chilean context. Methods: A joint team of intercultural PC educators from the US and Chile conducted a series of key informant interviews and a target audience survey to iteratively design a PC training course in Chile. Results: Eight key informant interviews identified a strong need for formal PC education pathways, confirmed the five central learning domains, and helped to identify potential course sub-topics. A target audience survey of 59 PC providers from across Chile confirmed a strong desire to participate in such a course. Conclusion: Our team of intercultural PC educators adapted an advanced PC course to the unique context of Chilean providers.
Circulating small extracellular vesicles microRNAs plus CA-125 for treatment stratification in advanced ovarian cancer
Authors: Zhou Xiaofang , Liu Mu , Sun Lijuan , Cao Yumei , Tan Shanmei , Luo Guangxia , Liu Tingting , Yao Ying , Xiao Wangli , Wan Ziqing , Tang Jie 
Published: December 2023

Abstract
Background
No residual disease (R0 resection) after debulking surgery is the most critical independent prognostic factor for advanced ovarian cancer (AOC). There is an unmet clinical need for selecting primary or interval debulking surgery in AOC patients using existing prediction models.

Methods
RNA sequencing of circulating small extracellular vesicles (sEVs) was used to discover the differential expression microRNAs (DEMs) profile between any residual disease (R0, n = 17) and no residual disease (non-R0, n = 20) in AOC patients. We further analyzed plasma samples of AOC patients collected before surgery or neoadjuvant chemotherapy via TaqMan qRT-PCR. The combined risk model of residual disease was developed by logistic regression analysis based on the discovery-validation sets.

Results
Using a comprehensive plasma small extracellular vesicles (sEVs) microRNAs (miRNAs) profile in AOC, we identified and optimized a risk prediction model consisting of plasma sEVs-derived 4-miRNA and CA-125 with better performance in predicting R0 resection. Based on 360 clinical human samples, this model was constructed using least absolute shrinkage and selection operator (LASSO) and logistic regression analysis, and it has favorable calibration and discrimination ability (AUC:0.903; sensitivity:0.897; specificity:0.910; PPV:0.926; NPV:0.871). The quantitative evaluation of Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI) suggested that the additional predictive power of the combined model was significantly improved contrasted with CA-125 or 4-miRNA alone (NRI = 0.471, IDI = 0.538, p < 0.001; NRI = 0.122, IDI = 0.185, p < 0.01).

Conclusion
Overall, we established a reliable, non-invasive, and objective detection method composed of circulating tumor-derived sEVs 4-miRNA plus CA-125 to preoperatively anticipate the high-risk AOC patients of residual disease to optimize clinical therapy.
Crescentic glomerulonephritis associated with syphilis: a case report and review of the literature
Authors: Kaiga Akiko , Sato Yuka , Arakawa Haruna , Rai Tatemitsu , Tojo Akihiro 
Published: December 2023

Abstract
Background
Crescentic glomerulonephritis with syphilis infection is rare, and the mechanism underlying the formation of glomerular capillary wall damage-induced crescent has not been elucidated.

Case presentation
A 62-year-old Japanese male showed edema, eruption, and rapid deterioration of the renal function after an acute syphilis infection. A renal biopsy showed crescentic glomerulonephritis with C3 deposition in the glomerular capillary wall, and immunostaining for anti-Treponema pallidum antibody was weakly positive in some interstitium and one glomerulus. Electron microscopy revealed the presence of string-shaped structures in the glomerular capillary walls. After treatment with penicillin followed by prednisolone, the renal function and urinary abnormalities, including Treponema pallidum protein, disappeared.

Conclusions
Crescentic glomerulonephritis associated with syphilis showed a string-shaped deposition in the glomerular capillary and urinary Treponema pallidum protein excretion, and was effectively treated with penicillin and prednisolone.
New refinements of the Cauchy–Bunyakovsky inequality
Authors: Montazeri Saeed 
Published: December 2023

AbstractThis paper presents new refinements on the integral form of Cauchy–Schwartz inequality known as Cauchy–Bunyakovsky inequality. It is proved that when we possess a weighted sum of a set of Cauchy–Bunyakovsky inequalities, there are two forms of refinements enhancing the precision of the original inequality. The superiority of one refinement over the other depends on the problem in which the presented theorem is utilized.
An overview of food insecurity during the global COVID-19 outbreak: transformative change and priorities for the Middle East
Authors: Doustmohammadian Azam , Fadavi Ghasem , Alibeyk Sepide , Hajigholam-Saryazdi Maryam , Mohammadi-Nasrabadi Fatemeh 
Published: December 2023

AbstractThe consequences of COVID-19 on the economy and agriculture have raised many concerns about global food security, especially in Middle Eastern countries, where unsustainable farming practices are widespread. Regarding the unprecedented crisis of the COVID-19 pandemic and the importance of early implementation of prevention programs, it is essential to understand better its potential impacts on various food security dimensions and indicators in these countries. In this scoping review, research databases were searched using a search strategy and keywords developed in collaboration with librarians. The review includes community trials and observational studies in all population groups. Two researchers separately conducted the literature search, study selection, and data extraction. A narrative synthesis was implemented to summarize the findings. The impacts of COVID-19 on three of four dimensions of food security through the food and nutrition system were identified: availability, accessibility, and stability. Disruption of financial exchanges, transportation, and closing of stores led to reduced production, processing, and distribution sub-systems. Rising unemployment, quitting some quarantined jobs, increasing medical healthcare costs, and increasing food basket prices in the consumption sub-system lead to lower access to required energy and nutrients, especially in the lower-income groups. Increased micronutrient deficiency and decreased immunity levels, increased overweight, obesity and non-communicable diseases would also occur. The current review results predict the effect of COVID-19 on food security, especially in vulnerable populations, and develop effective interventions. This review provides information for policymakers to better understand the factors influencing the implementation of these interventions and inform decision-making to improve food security.PROSPERO identifier: CRD42020185843.
Nanoscale inhomogeneity and the evolution of correlation strength in FeSe$$_{1-x}$$S$$_x$$
Authors: Liu Yu , Wang Aifeng , Du Qianheng , Wu Lijun , Zhu Yimei , Petrovic Cedomir 
Published: December 2023

AbstractWe report a comprehensive study of the nanoscale inhomogeneity and disorder on the thermoelectric properties of FeSe$$_{1-x}$$

1
-
x

S$$_x$$

x

($$0 \le x \le 1$$

0
≤
x
≤
1

) single crystals and the evolution of correlation strength with S substitution. A hump-like feature in temperature-dependent thermpower is enhanced for x = 0.12 and 0.14 in the nematic region with increasing in orbital-selective electronic correlations, which is strongly suppressed across the nematic critical point and for higher S content. Nanoscale Se/S atom disorder in the tetrahedral surroundings of Fe atoms is confirmed by scanning transmission electron microscopy measurements, providing an insight into the nanostructural details and the evolution of correlation strength in FeSe$$_{1-x}$$

1
-
x

S$$_x$$

x

.
First-episode psychosis intervention programme versus standard care for the clinical management of early phases of psychosis: cost analysis
Authors: Ibarrondo Oliver , Recio-Barbero María , Ustarroz Iker , Cabezas-Garduño Janire , Mentxaka Oihane , Acaiturri Teresa , Gómez Elisa , Segarra Rafael 
Published: December 2023

Background
Early intervention programmes (EIPs) in psychosis have gained attention as specialised interventions to improve health-related and societal impacts for people with psychotic disorders. Previous studies have presented evidence in favour of EIPs over the first year of intervention, despite none considering the critical period before psychosis onset (5 years).

Aims
To compare the associated costs of the First Episode Psychosis Intervention Program (CRUPEP) and treatment as usual (TAU) in a real-world cohort in a non-specialised psychiatric community setting.

Method
Direct and indirect mental health-related costs were calculated over 1 year and up to 7 years. Healthcare and societal costs were calculated from economic data related to the consumption of all healthcare resources, including emergency department attendances, hospital admissions, psychotropic medication prescriptions and societal costs.

Results
From a healthcare perspective, the intervention (CRUPEP) group initially showed a marginally higher cost per patient than the TAU group (€7621 TAU group v. €11 904 CRUPEP group) over the first year of follow-up. However, this difference was reversed between the groups on considering the entire follow-up, with the TAU group showing considerably higher associated costs per patient (€77 026 TAU v. €25 247 CRUPEP).

Conclusions
The EIP (CRUPEP) showed clinical benefits and minimised the direct and indirect health-related costs of the management of psychosis. Although the CRUPEP intervention initially reported increased costs over 1 year, TAU surpassed the global costs over the entire follow-up.
The BJPsych journals: open for business and faster than a speeding bullet in advancing psychiatry internationally
Authors: Malhi Gin S. 
Published: December 2023

SummaryThe Royal College of Psychiatry journals have an outstanding reputation for excellence, integrity and impact in psychiatry. Facilitated by Cambridge University Press, which is equally steeped in tradition, the family of College journals remains committed to enriching our understanding of mental science and exploring the clinical issues that matter.