bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enitociclib, a Selective CDK9 Inhibitor, Induces Complete Regression of MYC+ Lymphoma by Downregulation of RNA Polymerase II Mediated Transcription
Authors: Frigault Melanie M. , Mithal Arushi , Wong Harvey , Stelte-Ludwig Beatrix , Mandava Vinay , Huang Xin , Birkett Joseph , Johnson Amy J. , Izumi Raquel , Hamdy Ahmed 
Published: October 2023

Abstract

Double-hit diffuse large B-cell lymphoma (DH-DLBCL) is an aggressive, and often refractory, type of B-cell non–Hodgkin lymphoma (NHL) characterized by rearrangements in MYC and BCL2. Cyclin-dependent kinase 9 (CDK9) regulates transcriptional elongation and activation of transcription factors, including MYC, making it a potential targeted approach for the treatment of MYC+ lymphomas. Enitociclib is a well-tolerated and clinically active CDK9 inhibitor leading to complete metabolic remissions in 2 of 7 patients with DH-DLBCL treated with once weekly 30 mg intravenous administration. Herein, we investigate the pharmacodynamic effect of CDK9 inhibition in preclinical models and in blood samples from patients [DH-DLBCL (n = 10) and MYC+ NHL (n = 5)] treated with 30 mg i.v. once weekly enitociclib. Enitociclib shows significant regulation of RNA polymerase II Ser2 phosphorylation in a MYC-amplified SU-DHL-4 cell line and depletion of MYC and antiapoptosis protein MCL1 in SU-DHL-4 and MYC-overexpressing SU-DHL-10 cell lines in vitro. Tumor growth inhibition reaching 0.5% of control treated SU-DHL-10 xenografts is achieved in vivo and MYC and MCL1 depletion as well as evidence of apoptosis activation after enitociclib treatment is demonstrated. An unbiased analysis of the genes affected by CDK9 inhibition in both cell lines demonstrates that RNA polymerase II and transcription pathways are primarily affected and novel enitociclib targets such as PHF23 and TP53RK are discovered. These findings are recapitulated in blood samples from enitociclib-treated patients; while MYC downregulation is most robust with enitociclib treatment, other CDK9-regulated targets may be MYC independent delivering a transcriptional downregulation via RNA polymerase II.

Significance:
MYC+ lymphomas are refractory to standard of care and novel treatments that downregulate MYC are needed. The utility of enitociclib, a selective CDK9 inhibitor in this patient population, is demonstrated in preclinical models and patients. Enitociclib inhibits RNA polymerase II function conferring a transcriptional shift and depletion of MYC and MCL1. Enitociclib intermittent dosing downregulates transcription factors including MYC, providing a therapeutic window for durable responses in patients with MYC+ lymphoma.
All Christians Can Hear God’s Voice
Authors: Chrisna David Dwi 
Published: October 2023

Abstract
YWAM is one of the many actors that have played an important role in the “pentecostalization” of global Christianity. Rooted in a classical pentecostal denomination and committed to mission in the spirit of the ecumenical movement, YWAM has been a catalyst for the process of translating, introducing, and disseminating the pentecostal distinctives initially isolated only in classical pentecostal denominations and charismatic renewal groups to the broader Christian world. By looking at YWAM as a product of the classical pentecostal groups who struggled to define their relationship with other Christians, I argue that the pentecostal distinctives have two meanings. For some, they become a particular marker of identity that distinguishes Pentecostals from other Christians. For some others, like YWAM, it becomes a universal sign of spirituality that all Christians can experience.
The Holy Spirit in the Household
Authors: Sahoo Sarbeswar 
Published: October 2023

Abstract
Why are the Bhil tribals increasingly converting to Pentecostalism in India? Drawing on more than a decade of in-depth ethnographic fieldwork among the Bhils in southern Rajasthan, this article argues that the Pentecostals have approached conversion not as “change of religion” (dharma parivartan) but as “holistic transformation of life” (jeevan parivartan). In a context in which the state has been withdrawing from providing basic social services to people at its margins, the pentecostal churches have come to play a vital role. Specifically, the article discusses that the presence of the Holy Spirit has brought about three major transformations—miracle healing, ethical subjectivity, and gender relations—in the lives of the Bhils. Finally, the article concludes that by combining developmental programs with prayer and fellowship, the pentecostal churches have not only brought ethical transformations among the Bhils but have also converted them “to a morally inspired existence.”
The War in Ukraine and Arab Gulf States’ Foreign Policy Shifts
Authors: Dazi-Héni Fatiha 
Published: October 2023

Abstract
This paper discusses geopolitical shifts in the international order with regard to divergent perceptions and interests on the war in Ukraine between western states and the Gulf Cooperation Council states (gcc), specifically the Kingdom of Saudi Arabia (KSA) and the United Arab Emirates (UAE). These two leading gcc states now prioritise their own national interests by valuing multipolar partnerships, rather than solely relying on strong strategic ties with the West and US. The article aims to explore to what extent the war in Ukraine reveals a new phase in the power balance between the west and the Arab Gulf states. The initial outcomes of the war have already weakened Russia’s global status and forced Moscow to redirect its strategy towards the east, particularly China. This has also led to increased military cooperation between Russian and Iranian, as well as a rapprochement due to the weight of western economic sanctions imposed on both states. Concurrently, China’s significant role in world policy has become more evident through its direct political involvement in the restoration of Saudi-Iranian diplomatic relations, as seen in the agreement signed in Beijing on 10 March 2023. With the war in Ukraine significantly impacting the global energy market and regional power dynamics, the multipolar momentum gives the advantage to Gulf states that realise that this is an opportune time to capitalise on taking autonomous regional initiatives and fostering diversified partnerships from the west to the east.
Sustainable Seabed Mining—The Phase 1 Environmental Draft Standards and Guidelines
Authors: MacMaster Keith 
Published: October 2023

Abstract
The oceans are home to a rich diversity of plant and animal life and also provide a source of food and marine resources that drive economies. Climate change and pollution are changing ocean dynamics and the ability of the oceans to support life. Seabed mining in areas beyond national jurisdiction will add to the ocean’s stressors and could cause severe environmental damage. The International Seabed Authority (‘ISA’) is mandated to manage access to and benefits from the seabed, its subsoil, and mineral resources in areas beyond national jurisdiction (the ‘Area’). Although the United Nations Convention on the Law of the Sea sets out the legal framework for developing the Area and its resources, it does so in broad terms and leaves substantial gaps. These gaps include the scope of activities in the Area, the interrelationship of international obligations, the division of responsibilities between the ISA and sponsoring states, and the regulation of the mining system in situ. To partially fill these gaps, the ISA has drafted a set of ‘Phase 1’ Standards and Guidelines under the Draft Regulations on Exploitation of Mineral Resources in the Area. This paper investigates and critiques five environmental Draft Standards from a precautionary and comparative law perspective. Phase 1 standards and guidelines should adopt a more rigorous interpretation of the precautionary principle. Additional recommendations include creating enhanced governance processes and incorporating an ecosystem-based framework for regional environmental assessments and management plans not present in Draft Standards. This research will assist academics, practitioners, governments and the ISA with policies and strategies to enhance environmental and social protections from seabed mining.
Improving Postdoctoral Training Programs through Alumni Perspectives and Experiences: A Study of NCAR’s Advanced Study Program
Authors: Haacker Rebecca , Vara Marissa , Sloan Valerie , Montaño Patricia , Davis Chris , Landolt Scott , Briggs Scott 
Published: October 2023

Abstract
The Advanced Study Program (ASP) at the National Center for Atmospheric Research has supported the career development of postdoctoral fellows for over 60 years. This study of ASP alumni helps better understand their career paths and provides a window into the geoscience community. It examines career aspirations and job satisfaction, as well as experiences with mentoring and attitudes about diversity and inclusion in the workplace. While about half of ASP alumni today work in academia, job changes and pursuit of careers outside of academia are increasing. Former ASP participants are actively engaged in mentoring and are supportive of efforts in diversity, equity, and inclusion (DEI). Alumni who identify as women reported feeling less supported by their employers in their career growth and in their service activities such as mentoring than alumni who identify as men. The study also found that women engage in a broader range of DEI activities and mentor more often out of altruistic reasons rather than as an expectation of their position. In addition to mastering research and teaching skills, future postdocs will need training in leadership, grant writing, DEI, and project management to succeed in today’s geoscience workforce.
NOAA’s Air Resources Laboratory—75 Years of Research Linking Earth and Sky: A Historical Perspective
Authors: Stein Ariel F. , Hicks Bruce B. , Myles LaToya , Simon Margaret 
Published: October 2023

Abstract
For over 75 years, the National Oceanic and Atmospheric Administration’s Air Resources Laboratory (NOAA ARL) has been at the forefront of federal meteorological and climate research. As the Special Projects Section (SPS) of the U.S. Weather Bureau (USWB), the laboratory pioneered the development of atmospheric trajectory modeling, initially used in studies related to nuclear weapons following World War II. Model development was guided by observations following weapons tests, assisted by later experiments using a wide variety of atmospheric tracers. Today’s familiar Gaussian plume dispersion model, previously in nascent form, was developed and promoted with ARL research, as was the much later and widely used HYSPLIT model. Much of ARL’s early research was focused on the challenges presented by the complex terrain surrounding nuclear installations, often addressed with high-spatial-resolution meteorological measurements, atmospheric tracers, and site-specific models. ARL has since extended boundary layer research to increasingly complex landscapes, such as forests, agricultural lands, and urban areas, and has expanded its research scope to air quality, weather, and climate applications based on the knowledge and experience developed throughout its long history. Examples of these research endeavors include the establishment of the U.S. Climate Reference Network, fundamental contributions to the development of the National Air Quality Forecast Capability, and foundational participation in the National Atmospheric Deposition Program. ARL looks forward to continuing to refine scientific understanding from field experiments, including coupling ground-based experimentation with modeling, and sustained observations, in order to facilitate the transfer of knowledge into practical applications of societal relevance.
The Role of the Indian Ocean in Controlling the Formation of Multiyear El Niños through Subtropical ENSO Dynamics
Authors: Lin Yong-Fu , Yu Jin-Yi 
Published: October 2023

Abstract
This study explores the key differences between single-year (SY) and multiyear (MY) El Niño properties and examines their relative importance in causing the diverse evolution of El Niño. Using a CESM1 simulation, observation/reanalysis data, and pacemaker coupled model experiments, the study suggests that the Indian Ocean plays a crucial role in distinguishing between the two types of El Niño evolution through subtropical ENSO dynamics. These dynamics can produce MY El Niño events if the climatological northeasterly trade winds are weakened or even reversed over the subtropical Pacific when El Niño peaks. However, El Niño and the positive Indian Ocean dipole (IOD) it typically induces both strengthen the climatological northeasterly trades, preventing the subtropical Pacific dynamics from producing MY events. MY events can occur if the El Niño fails to induce a positive IOD, which is more likely when the El Niño is weak or of the central Pacific type. Additionally, this study finds that such a weak correlation between El Niño and the IOD occurs during decades when the Atlantic multidecadal oscillation (AMO) is in its positive phase. Statistical analyses and pacemaker coupled model experiments confirm that the positive AMO phase increases the likelihood of these conditions, resulting in a higher frequency of MY El Niño events.
The effect of X-ray computed tomography scan parameters on porosity assessment of carbon fibre reinfored plastics laminates
Authors: Galvez-Hernandez Pedro , Smith Ronan , Gaska Karolina , Mavrogordato Mark , Sinclair Ian , Kratz James 
Published: October 2023

Combinations of X-ray Computed Tomography (XCT) scan times, from 30 s to 60 min, and voxel sizes, from 6 to 50 µm, were investigated for their effect on the porosity measurements of a unidirectional carbon fibre epoxy composite volume. The sample had a total void volume of around 2%, which is typical of the tolerance expected in the aerospace industry. The volume contained localised voids that create sub-volumes with representative high (5%) and low (1%) porosity regions. The ability to detect small-size voids in the lower porosity regions decreased as the voxel size increased. Scan resolutions above 25 µm resulted in a coarser segmentation and overestimation of the porosity due to the presence of partial volume effects. Scan times shorter than 2 min resulted in noisy images, requiring aggressive filtering that affected the segmentation of voids. Porosity segmentation was performed by thresholding and Deep Learning methods. Deep Learning segmentation was found to recognise noise better, providing more consistent and cleaner segmented data than thresholding. To capture micro-voids that contribute to porosity levels at the typical aerospace tolerance of 2%, scan parameters with a voxel size equal to or smaller than 25 µm, scan times of 2 to 8 min, and deep learning segmentation were found to be the most promising. These shorter scan times can be used to increase the productivity of CT scanning for porosity or observing time-resolved events. The data provided here contributes to the body of knowledge studying X-ray hardware settings and optimising image segmentation.
Fiber movement during twisting in air vortex spinning
Authors: Wang Qing , Lv Xushan , Dang Shuai , Liang Gaoxiang , Jiang Yuefu , Zhao Tiantian 
Published: October 2023

In order to clarify the twisting mechanism of the air vortex spinning machine, this paper investigates the motion law of air vortex spinning fiber from the guided access into the twisting chamber during the whole process. While considering the bi-directional coupling effects of the airflow and fiber, the airflow–fiber fluid–solid coupling solution model of the guiding parts is established, and the fluid–solid bi-directional coupling solution platform is built based on ANSYS Workbench software. The movement trajectories of fibers in the process of single and double fibers entering the twisting zone from the guiding channel to the hollow spindle guiding channel were obtained, respectively. Through the fluid–solid coupling analysis, (1) under the action of airflow, the fiber movement is complex and variable, while the movement of the fiber affects the distribution of the surrounding airflow velocity and pressure. (2) Due to the asymmetric structure of the guiding channel, the airflow distribution on both sides of the fiber in motion is uneven, so that the fiber as a whole is wavy forward, and from time to time collisions occur with the tube wall. (3) The fibers are sucked into the twisting chamber under the effect of pressure difference, and the fibers are twisted under the combined effect of axial airflow and tangential airflow. The head end of the fiber enters the guided access in the middle of the hollow spindle under the guidance of the guiding pins. (4) In double fiber movement, there will be mutual adsorption, fibers becoming closer together, contact, stagger, separation and other phenomena that also affect the fiber in the airflow under the action of the twisting winding movement process.
Mycophenolate mofetil increases the risk of diarrhea in allogeneic hematopoietic stem cell transplantation recipients
Authors: Lin Liangmo , Hong Mianhui , Fu Xiangjun 
Published: October 2023

Objectives Mycophenolate mofetil (MMF) was reported to be a main cause of diarrhea following organ transplantation. However, research on MMF-induced diarrhea following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently insufficient. This retrospective study examined the incidence of MMF-induced diarrhea among allo-HSCT recipients. Methods Recipients were divided according to the receipt of MMF and the appearance of diarrhea. The differences in clinical information, MMF usage and trough concentrations, and the occurrence of diarrhea from the first day of conditioning treatment to 100 days after transplantation were analyzed. Results In total, 32.9% of the recipients reported diarrhea. The incidence rate of diarrhea was higher in the MMF group than in the non-MMF group (40.0% vs. 16.7%). MMF-induced diarrhea usually occurred within 9 days of MMF initiation and persisted for 7.27 ± 3.54 days. The average body weight, MMF daily dose, and MMF trough concentration were higher in patients with diarrhea. Conclusion MMF increased the risk of diarrhea in allo-HSCT recipients, and the risk was related to the MMF dose and trough concentration. The difference in onset time could be a basis for identifying the cause of diarrhea in allo-HSCT recipients.
Body mass index and migraine in adolescence: A nationwide study
Authors: Zloof Yair , Tsur Avishai M. , Simchoni Maya , Derazne Estela , Tzur Dorit , Honig Asaf , Braun Maya , Ganelin-Cohen Esther , Amarilyo Gil , Pinhas-Hamiel Orit , Afek Arnon , Twig Gilad 
Published: October 2023

Background The association between body mass index (BMI) and migraine in adults has been well established. However, studies in children and adolescents are inconclusive. We aimed to study the association between BMI and migraine using a national dataset that comprises the electronic medical records of more than two million adolescents. Methods This study included all Israeli adolescents (57.7% males, 42.3% females; mean age 17 years) who were medically assessed before mandatory military service during 1990-2020. As part of the pre-recruitment medical assessment, all the adolescents were screened for migraine and their height and weight were measured. Diagnoses of migraine were confirmed by board-certified neurologists. Prevalences and odds ratios (ORs) for migraine were computed across BMI subgroups. Spline models were applied. Results A total of 2,094,862 adolescents were included, of whom 57,385 (2.8%) had active migraine. Among males, the adjusted ORs for migraine were 1.11 (95% confidence interval, 1.06-1.16), 1.13 (1.08-1.17), and 1.24 (1.19-1.30), for the underweight, overweight, and obesity subgroups, respectively, compared to the reference group of low-normal BMI (5th-49th percentile). Among females, the respective adjusted ORs were 1.12 (1.05–1.19), 1.23 (1.19–1.28), and 1.38 (1.31–1.46). Results persisted in sensitivity analyses accounting for other medical and psychiatric comorbidities and parental history of migraine. Spline models demonstrated a J-shaped relation between BMI and migraine. Conclusions Both adolescent obesity and underweight were associated with migraine in a sex-dependent manner. This association peaked in female adolescents with overweight and obesity.
Phytochemical Profiling and Assessment of Habbe Musaffe Khoon Against Cervical Cancer
Authors: Sharma Nidhi , Raina Prerna , Mulla Ghazalla , Shindikar Anand , Patil Prajakta , Bhalerao Supriya , Kaul-Ghanekar Ruchika 
Published: October 2023

Background In India, cancer of the cervix is the second most common cancer in women. Nowadays, various traditional herbal formulations can be used as adjuncts during conventional cancer therapies due to their anticancer activity. Habbe Musaffi Khoon (HMK), a Unani compound formulation, is traditionally used as a blood purifier and thus used to treat boils, scabies, acne, and pimples. It is also indicated in skin diseases, Habis-ud-Dam (styptic), and therapeutically used in Nafz-ud-Dam (hemorrhagic). Objectives The main purpose of this work was to phytochemically characterize HMK aqueous extract (HMKaq) and determine its activity against cervical cancer cells. Materials and Methods HMKaq was subjected to liquid chromatography-mass spectrometry (LC-MS) and evaluated for the presence of phytocompounds. HMKaq was evaluated for its effect on the viability of cervical cancer cells (HeLa, SiHa, and C33A) and was determined by MTT assay. Trypan blue dye exclusion was used to determine the outcome of HMKaq on the growth kinetics of cervical cancer cells. The role of HMK in regulating the cell cycle was analyzed by FACS and its effect on apoptosis was evaluated by checking mitochondrial membrane potential readings of JC-1 aggregates on a microplate reader and on the mRNA expression of caspase-3 and cytochrome C was evaluated by PCR. Results LC-MS analysis revealed 3845 compounds, out of which 58 were the major compounds. These included phenolics, esters, fatty acids, furans, quinones, tannins, flavonoids, and terpenes. HMKaq reduced the viability and growth of the cells. It induced arrest in the cell cycle of HeLa and apoptosis in SiHa and C33A by depolarizing the membrane potential of the mitochondria and upregulation of mRNA expression of Cas3 and Cyt C. Conclusion HMK exhibited anticancer activity against cervical cancer cells, thereby signifying its therapeutic potential.
Active noise control with resonant flush-mounted piezoelectric cells in the presence of airflow: Wind tunnel experiments
Authors: Rodriguez Jonathan , Ezzine Mouhamed , Collet Manuel , Clair Vincent 
Published: October 2023

Methods and technologies to control the noise coming from turbulent flows impinging on outlet guide vanes in turbofan engines are tremendously needed nowadays to comply with new legislation on acoustic environment pollution. The following paper relies on preliminary research proposing a new experimental design of active noise control system to be further integrated into a jet engine outer guide vane prototype, consisting of multiple flush-mounted piezoelectric cells. Here, three active cells are placed on the bottom wall of a wind tunnel with upstream acoustic excitation generating grazing incident waves for different airflow velocities. Using a downstream microphone as an error sensor, the active system succeeds in improving the transmission loss of the sample by 2.5 dB at the target frequency (670 Hz) corresponding to the main piezo acoustic mode with airflow velocities up to 20 m.s−1. These early experimental results confirm the ability of the concept to interact with the ambient acoustics without disturbing the airflow as in passive solutions using porous materials, for instance, leading the path to future experiments with realistic turbulence generating acoustic sources on the leading edge of the vane profile.