bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pentafluorophenyl‐Substituted Proline‐Derived Chiral Urea for “On Water” Asymmetric Hydrogen‐Bonding Catalysis
Authors: Wang Bingfu , Li Tianxing , Liu Jian , Wang Shuo , Shi Hu , Jin Hui , Ryu Do Hyun , Zhang Lixin 
Published: October 2023

AbstractThis work demonstrated the efficacy of a proline‐derived chiral urea for “on water” asymmetric hydrogen‐bonding catalysis by incorporating a hydrophobic and electron‐withdrawing pentafluoro‐phenyl substituent into the urea moiety. When employed as a catalyst, pentafluorophenyl‐substituted proline‐derived chiral urea exhibited significant enhancement of both the reaction rate and stereoselectivity when conducted “on water” compared to that of conventional organic solvents due to the hydrophobic hydration effect. Moreover, this catalyst did not display notable self‐aggregation during the “on water” hydrogen‐bonding catalysis and was confirmed to exist as a monomeric species with catalytic activity. Due to its remarkable acceleration in “on water” conditions, the catalyst load was significantly reduced. Consequently, complete conversion was achieved at room temperature within 2 hours while maintaining good enantioselectivities (up to 96% ee) even at 0.2 mol% catalyst loading in the Michael addition of dithiomalonate to nitrostyrene.
Recent Advances in the 1,2‐Diarylation of Alkenes
Authors: Jose Jisna , Mathew Thomas V. 
Published: October 2023

AbstractAlkenes are a fascinating functional class that can be converted into various structures. A desirable and durable synthetic method for forming two C−C bonds across an olefin is the dicarbofunctionalization of olefins, catalyzed by transition metals. This method enables a rapid expansion of molecular complexity in a single step. Among the myriad of efficient strategies for alkene difunctionalization, the 1,2‐diarylation mode stands out primarily due to its remarkable ability to incorporate two hindered aryl groups across the C=C bond in a versatile and straightforward manner. This review covers the recent advances in the 1,2‐diarylation of alkenes from 2018 to 2023, focusing on different transition metals employed as catalysts.
A Colorimetric Biosensing Platform with Aptamers, Rolling Circle Amplification and Urease‐Mediated Litmus Test
Authors: Chang Dingran , Li Jiuxing , Liu Rudi , Liu Meng , Tram Kha , Schmitt Natalie , Li Yingfu 
Published: October 2023

AbstractHere we report on an ultra‐sensitive colorimetric sensing platform that takes advantage of both the strong amplification power of rolling circle amplification (RCA) and the high efficiency of a simple urease‐mediated litmus test. The presence of a target triggers the RCA reaction, and urease‐labelled DNA can hybridize to the biotinylated RCA products and be immobilized onto streptavidin‐coated magnetic beads. The urease‐laden beads are then used to hydrolyze urea, leading to an increase in pH that can be detected by a simple litmus test. We show this sensing platform can be easily integrated with aptamers for sensing diverse targets via the detection of human thrombin and platelet‐derived growth factor (PDGF) utilizing structure‐switching aptamers as well as SARS‐CoV‐2 in human saliva using a spike‐binding trimeric DNA aptamer. Furthermore, we demonstrate that this colorimetric sensing platform can be integrated into a simple paper‐based device for sensing applications.
The influence of green human resource management on environmental performance: An empirical study investigated in the pollutant industries of Pakistan
Authors: Shakil Muhammad Haseeb , Mukarram Muhammad , Hussain Ghulam , Idrees Rana Nadir , Sajjad Ali 
Published: October 2023

AbstractThis research mainly aims to test the impact of green human resource management (GHRM) on environmental performance (EP) and to determine whether corporate social responsibility (CSR) mediates the relationship between GHRM and EP and whether organizational citizenship behavior (OCB) moderates the relationships between CSR and EP. The paper relied on a quantitative research approach with a sample of 204 employees from the pollutant industries of Pakistan. In this paper, the partial least square approach (PLS‐SEM) was employed to verify the proposed hypotheses. The outcomes confirmed that GHRM has a positive impact on EP. Additionally, the findings indicated that CSR affected EP. It was also revealed that CSR fully mediates the linkages between GHRM and EP. This paper acknowledges the existing gaps in the prior literature and enables us to clearly understand the significance of GHRM in affecting EP via CSR as a mediator.
Risk factors associated with preferential lateral lymph node metastasis in papillary thyroid carcinoma
Authors: Shao Liang , Wang Zhihong , Dong Wenwu , Sun Wei , Zhang Hao 
Published: October 2023

AbstractBackgroundLateral lymph node metastasis (LLNM) is common in patients with papillary thyroid cancer (PTC), usually occurring after central lymph node metastasis (CLNM). However, some patients experience LLNM without first developing CLNM. This study aimed to identify the risk factors for developing LLNM without CLNM.MethodsWe retrospectively reviewed 421 patients diagnosed with PTC who underwent lobectomy or total thyroidectomy with central and ipsilateral lateral lymph node dissection. We collected clinicopathological data and used univariate and multivariate logistic regression analyses to determine the risk factors associated with LLNM without CLNM.ResultsThe LLNM without CLNM frequency was 18.3% (77/421). Univariate analyses demonstrated that age over 55 years, primary tumor in the upper portion of the thyroid, the number of central lymph node (CLN) and LLNM, primary tumor size, and the summed size of multi‐foci tumors smaller than 1 cm were significantly associated with LLNM without CLNM (p < 0.05). Multivariate analysis revealed that LLNM without CLNM was more likely to occur in patients aged ≥55 years (odds ratio [OR], 2.309; 95% confidence interval [CI], 1.133–4.704; p = 0.021), and primary tumor in the upper portion of the thyroid (OR, 0.524; 95% CI, 0.295–0.934; p = 0.028).ConclusionThe lymph node metastasis pattern in patients with PTC is not constant. Therefore, surgeons should evaluate the lateral lymph nodes, especially in patients older than 55 years or when the primary tumor is in the upper portion of the thyroid.
Modified nail folding approach: A novel strategy for the treatment of subungual glomus tumors—A case series study
Authors: Ahangar Parviz , Akbaribazm Mohsen , Rahimi Mohsen , Pirmohamadi Hosein 
Published: October 2023

Key Clinical MessageThe modified nail folding approach, a new surgical technique, has been shown to be safe and effective for the treatment of subungual glomus tumors, providing clinicians with a new treatment option for patients with this condition.AbstractGlomus tumors (GTs) are rare benign tumors that originate from the glomus body in the skin of the fingertips, toes, and nail beds. GTs are more prevalent in women than in men and can occur sporadically or as part of an inherited condition known as multiple GTs. The exact cause of GTs is unknown, but it is believed that mutations in the cells of the glomus body contribute to their development. In this study, we present the efficacy of a novel surgical technique called the modified nail folding approach for treating subungual GTs. We report a case series involving 17 patients who underwent the nail folding approach for surgical removal of subungual GTs. The primary objective of this article is to provide evidence supporting the safety and effectiveness of this technique. Additionally, we aim to introduce clinicians to a new, secure, and efficient treatment option for patients with subungual GTs.
Esophageal squamous carcinoma in a 25‐year‐old female, changing trend in epidemiology: A case report
Authors: Karki Deepika , Pant Prashant , Shrestha Asim , Chhetri Suchit Thapa , Kadel Isabel , Karna Gagan Prakash 
Published: October 2023

Key Clinical MessageTimely diagnosis, comprehensive assessment, and a multidisciplinary treatment approach are essential for young patients with esophageal squamous cell carcinoma, even when conventional risk factors are absent. This report emphasizes the need for increased clinical awareness and improved patient outcomes in an evolving epidemiological landscape.
Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes
Authors: Hofmann Silja , Winter Johannes , Prenzel Tobias , de Jesús Gálvez‐Vázquez María , Waldvogel Siegfried R. 
Published: October 2023

AbstractIsoxazol(in)es are widely featured structural motifs in natural products, agrochemicals, and pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis from readily available aldoximes is reported. Isoxazoles and isoxazolines were obtained in yields up to 81 %. The synthesis is carried out in an undivided cell as the simplest electrochemical set‐up and requires only the use of electric current as traceless oxidizing agent. The application of inexpensive and widely available electrode materials in combination with recyclable supporting electrolytes and solvents paves the path for translation of the presented reaction onto preparative scale. This is underlined by successful scale‐up to multi‐gram runs.
Unexpected Reduction of a Coordinated Diazapyridinophane Ligand Bound to Chromium(III) Ion Leading to Delocalization of the Unpaired Electron across Two Isolated Pyridine Units
Authors: Krämer Kristin , Schmitz Markus , Kelm Harald , van Wüllen Christoph , Krüger Hans‐Jörg 
Published: October 2023

AbstractIn the tetraazamacrocyclic ligand N,N’‐dimethyl‐2,11‐diaza‐[3.3](2,6)pyridinophane (L‐N4Me2), the two pyridine units are separated from each other by sp3‐hybridized triatomic bridges. Such electronically isolated pyridine moieties are considerably less prone to reductions than di‐ or triimines. A detailed structural, magnetic, and spectroscopic investigation of the complexes [Cr(L‐N4Me2)(OAc)2] and [Cr(L‐N4Me2)(OAc)2](PF6), in combination with theoretical calculations, reveals that the reduced complex must be described as a chromium(III) ion coordinated to the anionic radical ligand (L‐N4Me2)⋅− rather than a low‐spin chromium(II) ion bound to closed‐shell ligands. Thus, it is, to the best of our knowledge, only the second example of a stable and structurally characterized metal complex containing a reduced isolated pyridine unit. The stability is attributed to the delocalization of the unpaired electron across the two pyridine units, mediated by their interaction to the metal ion.
Computational Insights into SN2 and Proton Transfer Reactions of CH3O− with NH2Y and CH3Y
Authors: Feng Huining , Li Rui , Wu Yang , Liu Xu 
Published: October 2023

AbstractBimolecular nucleophilic substitution (SN2) reactions have been extensively studied in both theory and experiment. While research on C‐centered SN2 reactions (SN2@C) has been ongoing, SN2 reactions at neutral nitrogen (SN2@N) have received increased attention in recent years. To recommend methods for dynamics simulations, the comparison for the properties of the geometries, vibrational frequencies, and energies is done between MP2 and six DFT functional calculations and experimental data as well as the high‐level CCSD(T) method for CH3O−+NH2Cl/CH3Cl reactions. The relative energy diagrams at the M06 method for CH3O− with CH3Y/NH2Y reactions (Y=F, Cl, Br, I) in the gas and solution phase are explored to investigate the effects of the leaving groups, different reaction centers, and solvents. We mainly focus on the computational of inv‐SN2 and proton transfer (PT) pathways. The PT channel in the gas phase is more competitive than the SN2 channel for N‐center reactions, while the opposite is observed for C‐centered reactions. Solvation completely inhibits the PT channel, making SN2 the dominant pathway. Our study provides new insight into the SN2 reaction mechanisms and rich the novel reaction model in gas‐phase organic chemistry.
Application of environmental DNA metabarcoding and quantitative PCR to detect blooming jellyfish in a temperate bay of northern China
Authors: Peng Saijun , Wang Lei , Ma Yuanqing , Ye Lijing , Hou Chaowei , Liu Yongliang , Li Yongxue , Sun Tingting , Zhao Jianmin , Dong Zhijun 
Published: October 2023

AbstractFrequently occurring jellyfish blooms have severe impacts on the socioeconomics of coastal areas, which stress the importance of early detection and assessments of blooming jellyfish taxa. Environmental DNA (eDNA) techniques (quantitative PCR and eDNA metabarcoding) have the advantage of high sensitivity and are an emerging powerful tool for investigations of target species. However, a comprehensive analysis of the biodiversity and biomass of jellyfish taxa in the target area by combining the two eDNA techniques is still lacking. Here, we developed eDNA metabarcoding and quantitative PCR for the detection and assessment of jellyfish taxa in the temperate Yantai Sishili Bay (YSB) and estimated the spatial distribution of Aurelia coerulea. Species‐specific quantitative PCR assays targeting the mitochondrial cytochrome c oxidase subunit I gene of A. coerulea were developed. Additionally, eDNA metabarcoding based on the mitochondrial 16S rDNA sequences identified six jellyfish species in YSB. Moreover, our results indicate that A. coerulea aggregations were more likely to occur in the inner part of the bay than in the outer part, and they gathered in the bottom layer of seawater rather than in the surface layer. Our results demonstrate the potential of two eDNA techniques in jellyfish biomass investigation and jellyfish taxa detection. These eDNA techniques may contribute to the discovery of jellyfish aggregation so as to achieve early warning of large‐scale jellyfish blooms in coastal areas.
(−)‐Epigallocatechin gallate alleviates chronic unpredictable mild stress‐induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation
Authors: Zhang Yulin , Wu Hongxian , Xu Chaozhi , Li Shanqian , Hu Yue , Zhang Zongyi , Wu Guixian , Liu Yuling , Yang Lin , Huang Yue , Lu Wenjun , Hu Lina 
Published: October 2023

AbstractDepression is a global public health issue that is widely studied due to the large number of people it affects and its serious consequences. Clinical studies have shown that regular tea consumption may reduce depression risk. (−)‐Epigallocatechin gallate (EGCG), the main tea polyphenol, was observed to alleviate depression, but the underlying mechanism has not been elucidated. In this study, chronic unpredictable mild stress (CUMS) was used to induce depression‐like behavior in mice, and behavioral tests, such as sucrose preference test and forced swim test, were performed. Then, ELISA, western blot and QT‐PCR tests were used to assess the expression of the key components of the NLRP3 inflammasome and its downstream inflammatory effectors (e.g., IL‐1β, IL‐18), autophagy markers (Beclin‐1, LC3, P62) and apoptosis markers (Bax, Bcl‐2) in mouse brain tissues. Changes in serum lipid levels were also assessed. EGCG alleviated CUMS‐induced depression‐like behavioral changes in mice, reduced activation of the NLRP3 inflammasome, inhibited the mTOR signaling pathway, restored autophagy levels, reduced apoptosis marker expression and attenuated abnormal changes in blood lipid levels. Our study demonstrates that EGCG exerts antidepressive effects through multiple mechanisms, providing new insight into the pathological mechanism of depression and laying the foundation for the development of new therapeutic measures.
Quality and antioxidant activity of dandelion root infusions as affected by cold plasma pretreatment
Authors: Elcik Berfin Eda , Kirkin Celale 
Published: October 2023

AbstractGround and unground dandelion roots were subjected to dielectric barrier discharge cold plasma (DBDCP) at 40 kV for 0 (control), 10, or 20 min. Then, infusions of the pretreated dandelion roots in water were prepared, and the changes in color, total phenolic content (TPC), antioxidant activity, and sensory properties were investigated. The 20‐min pretreatment increased the b* value, TPC, antioxidant activity, and sage odor of the ground dandelion root infusions compared with the control, whereas decreases in the TPC, antioxidant activity, and sage odor were noted in the 10‐min pretreated infusions of the unground roots. DBDCP pretreatment did not affect the overall likeliness of infusions of ground and unground roots. In addition, the TPC, antioxidant activity, and overall likeliness of infusions of the ground dandelion roots were higher than those of the unground samples. In conclusion, it can be said that the DBDCP pretreatment can be utilized to improve the TPC and antioxidant activity of ground dandelion roots.
Preparedness of Iranian nurses against COVID‐19: An analytical study
Authors: Ahmadi Marzaleh Milad , Peyravi Mahmoudreza , Shokrpour Nasrin , Khaledi Firouz , Shaikhy Rahimali , Saadatmand Vahid , Khaledi Hassan 
Published: October 2023

AbstractBackground and AimsThe reasons for the unfavorable performance of hospitals in providing care to Coronavirus Disease 2019 (COVID‐19) patients include the lack of preparation, knowledge, and relevant skills, making it necessary to evaluate the preparedness of nurses to respond to COVID‐19. Therefore, the present study aimed to investigate the preparedness of hospitals affiliated with Shahrekord University of Medical Sciences during the COVID‐19 pandemic in 2022.MethodsIn this analytical study, data were collected from 350 randomly selected nurses who worked in three hospitals affiliated with Shahrekord University of Medical Sciences; demographic information tools and the preparation of nurses for COVID‐19 patients were used to collect the data. We analyzed the data using SPSS software version 26.ResultsThe mean and standard deviation of the total preparation score was 118.85 ± 0.98. The lowest (6.80 ± 0.18) and highest (23.35 ± 0.19) average values belonged to risk assessment and management and COVID‐19, respectively. The score of nurses' preparedness to deal with COVID‐19 was not statistically correlated with age, work experience, and so on. The average preparation score was significantly different in different treatment departments (operating room and COVID‐19).ConclusionThe preparation of nurses was low in dealing with COVID‐19. Thus, managers of nursing services should design and implement educational programs to strengthen the nurses' weaknesses and ultimately increase their awareness and skills in dealing with disasters.
Three‐dimensional multicellular biomaterial platforms for biomedical application
Authors: Hao Jianxin , Qin Chen , Wu Chengtie 
Published: October 2023

AbstractThe three‐dimensional (3D) multicellular platforms prepared by cells or biomaterials have been widely applied in biomedical fields for the regeneration of complex tissues, the exploration of cell crosstalk, and the establishment of tissue physiological and pathological models. Compared with the traditional 2D culture methods, the 3D multicellular platforms are easier to adjust the components and structures of extracellular matrix (ECM) because of the synthesis of ECM by cells and the use of biomaterials. Moreover, the 3D multicellular platforms also can customize the cell distribution and precisely design micro and macro structures of the systems. Based on these typical advantages of 3D multicellular platforms and their increasingly important position in the biomedical field, this review summarizes the present 3D multicellular platforms. Herein, current 3D multicellular platforms are divided into two major types: scaffold‐free and scaffold‐based 3D multicellular platforms. The specific characteristics and applications of different types of 3D multicellular platforms are thoroughly introduced to help readers understand how different models affect and regulate cell behaviors and inspire researchers on how to select and design suitable 3D multicellular platforms according to different application scenarios.
Anisotropy, Anatomical Region, and Additional Variables Influence Young's Modulus of Bone: A Systematic Review and Meta‐Analysis
Authors: Kovács Krisztián , Váncsa Szilárd , Agócs Gergely , Harnos Andrea , Hegyi Péter , Weninger Viktor , Baross Katinka , Kovács Bence , Soós Gergely , Kocsis György 
Published: October 2023

ABSTRACTThe importance of finite element analysis (FEA) is growing in orthopedic research, especially in implant design. However, Young's modulus (E) values, one of the most fundamental parameters, can range across a wide scale. Therefore, our study aimed to identify factors influencing E values in human bone specimens. We report our systematic review and meta‐analysis based on the recommendation of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) 2020 guideline. We conducted the analysis on November 21, 2021. We included studies investigating healthy human bone specimens and reported on E values regarding demographic data, specimen characteristics, and measurement specifics. In addition, we included study types reporting individual specimen measurements. From the acquired data, we created a cohort in which we performed an exploratory data analysis that included the explanatory variables selected by random forest and regression trees methods, and the comparison of groups using independent samples Welch's t test. A total of 756 entries were included from 48 articles. Eleven different bones of the human body were included in these articles. The range of E values is between 0.008 and 33.7 GPa. The E values were most heavily influenced by the cortical or cancellous type of bone tested. Measuring method (compression, tension, bending, and nanoindentation), the anatomical region within a bone, the position of the bone within the skeleton, and the bone specimen size had a decreasing impact on the E values. Bone anisotropy, specimen condition, patient age, and sex were selected as important variables considering the value of E. On the basis of our results, E values of a bone change with bone characteristics, measurement techniques, and demographic variables. Therefore, the evaluation of FEA should be performed after the standardization of in vitro measurement protocol. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Osmoregulatory and immunological role of new canceled cells: Mitochondrial rich cells and its future perspective: A concise review
Authors: Ali Waseem , Chen Yan , Hassan Mohammad Farooque , Wang Tao , Khatyan Uzma , Sun Jian , Liu Zongping , Zou Hui 
Published: October 2023

AbstractMitochondrial‐rich cells (MRCs) are one of the most significant canceled type of epithelial cells. Morphologically these cells are totally different from other epithelial cells. These cells primarily implicated in sea‐water and fresh‐water adaptation, and acid–base regulation. However, in this review paper, we explored some of the most intriguing biological and immune‐related functional developmental networks of MRCs. The main pinpoint, MRCs perform a dynamic osmoregulatory and immunological functional role in the gut and male reproductive system. The Na+/K+_ATPase (NKA) and Na+/K+/2Cl cotransporter (NKCC) are key acidifying proteins of MRCs for the ion‐transporting function for intestinal homeostasis and maintenance of acidifying the luminal microenvironment in the male reproductive system. Further more importantly, MRCs play a novel immunological role through the exocrine secretion of nano‐scale exosomes and multivesicular bodies (MVBs) pathway, which is very essential for sperm maturation, motility, acrosome reaction, and male sex hormones, and these an essential events to produce male gametes with optimal fertilizing ability. This effort is expected to promote the novel immunological role of MRCs, which might be essential for nano‐scale exosome secretion.