bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Emissions and Costs in Solar Power: A Novel Approach with Aluminum Wiring
Authors: Sayyah Ali , Ahangari Mohammad , Mostafaei Jafar , Niaei Aligholi 
Published: January 2024

Abstract

One of the standout methods for harnessing renewable energy involves the conversion of solar radiation into electricity using solar cells. The globalization of photovoltaic systems faces challenges, such as balancing environmental, technical, and economic factors. This is addressed through the application of multi-criteria decision-making (MCDM) techniques, which are integral to sustainability. This study aims to determine optimal paths for electricity generation from solar panels, prioritizing minimal environmental impact, maximum efficiency, and the shortest cost payback period (CPP). After evaluating 108 different scenarios based on solar cell type, wiring material, wire sections, and pitch decisions, three solutions were identified. Decision-making tools were employed to select configurations that exhibited the least life cycle emissions, highest grid power injection capability, and the shortest CPP. A notable discovery is the recommendation to use aluminum wires instead of copper wires for electric installation, offering greater benefits. This finding underscores the significance of life cycle assessment in advising sustainable technology choices for solar power plants worldwide, challenging conventional practices like the use of copper wires.
Neuroinflammation driven by Human Immunodeficiency Virus-1 (HIV-1) directs the expression of long noncoding RNA RP11-677M14.2 resulting in dysregulation of Neurogranin in vivo and in vitro.
Authors: Reis Roberta S. Dos , Wagner Marc C.E. , McKenna Savannah , Ayyavoo Velpandi 
Published: January 2024

Abstract
Neuroinflammation and synaptodendritic damage represent the pathological hallmarks of HIV-1 associated cognitive disorders (HAND). The post-synaptic protein neurogranin (Nrgn) is significantly reduced in the frontal cortex of postmortem brains from people with HIV (PWH) and it is associated with inflammatory factors released by infected microglia/macrophages. However, the mechanism involved in synaptic loss have yet to be elucidated. In this study, we characterized a newly identified long non-coding RNA (lncRNA) transcript (RP11-677M14.2), which is antisense to the NRGN locus and is highly expressed in the frontal cortex of HIV-1 individuals. Further analysis indicates an inverse correlation between the expression of RP11-677M14.2 RNA and Nrgn mRNA. Additionally, the Nrgn-lncRNA axis is dysregulated in neurons exposed to HIV-1 infected microglia conditioned medium enriched with IL-1b. Moreover, in vitro overexpression of this lncRNA impact Nrgn expression at both mRNA and protein levels. Finally, we modeled the Nrgn-lncRNA dysregulation within an HIV-1-induced neuroinflammatory environment using brain organoids, thereby corroborating our in vivo and in vitro findings. Together, our study implicates a plausible role for lncRNA RP11-677M14.2 in modulating Nrgn expression that might serve as the mechanistic link between Nrgn loss and cognitive dysfunction in HAND, thus shedding new light on the mechanisms underlying synaptodendritic damage.
Changes in respiratory infection trends during the COVID-19 pandemic in patients with haematologic malignancy
Authors: Ryoo Jiwon , Kim Seok Chan , Lee Jongmin 
Published: January 2024

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has changed respiratory infection patterns globally. However, its impact on community-acquired pneumonia (CAP) in high-risk patients with haematological malignancies (HM) is uncertain. We aimed to examine how community-acquired pneumonia aetiology in patients with haematological malignancies changed during the COVID-19 pandemic.
Methods: This was a retrospective study that included 524 patients with haematological malignancies hospitalised with community-acquired pneumonia between March 2018 and February 2022. Patients who underwent bronchoscopy within 24 hours of admission to identify community-acquired pneumonia aetiology were included. Data on patient characteristics, laboratory findings, and results of bronchioalveolar lavage fluid cultures and polymerase chain reaction tests were analysed and compared to identify changes and in-hospital mortality risk factors.
Results: Patients were divided into the ‘pre-COVID-19 era’ (44.5%) and ‘COVID-19 era’ (55.5%) groups. The incidence of viral community-acquired pneumonia significantly decreased in the COVID-19 era, particularly for influenza A, parainfluenza, adenovirus, and rhinovirus (pre-COVID-19 era vs. COVID-19 era: 3.0% vs. 0.3%, P = 0.036; 6.5% vs. 0.7%, P = 0.001; 5.6% vs. 1.4%, P = 0.015; and 9.5% vs. 1.7%, P < 0.001, respectively), whereas that of bacterial, fungal, and unknown community-acquired pneumonia aetiologies remain unchanged. Higher Sequential Organ Failure Assessment scores and lower platelet counts correlated with in-hospital mortality after adjusting for potential confounding factors.
Conclusions: In the COVID-19 era, the incidence of community-acquired pneumonia with viral aetiologies markedly decreased among patients with haematological malignancies, with no changes in the incidence of bacterial and fungal pneumonia. Further studies are required to evaluate the impact of COVID-19 on the prognosis of patients with haematological malignancies and community-acquired pneumonia.
The research protocol of unpacking the “mind” and “body” pathways of antidepressant effects of school children with obesity in Hong Kong
Authors: Miao Chuhan , Ning Wenjing , Li Beilei , Bo Yan 
Published: January 2024

Abstract
Background
This study will investigate the effects of Qigong, mindfulness, and low-intensity exercise on the mental and physical health of obese school children (6–18 years old). It seeks to unpack the mechanisms through which these mind-body interventions impact depressive symptoms in this population since these effects and the underlying pathways through which they exert their antidepressant effects remain unclear.
Methods
This protocol proposes a randomised controlled trial (RCT). It will recruit a sample of obese school children and randomly assign them to a qigong, mindfulness, low-intensity exercise, or control group first. Then, it will implement the interventions over a specified period and conduct pre- and post-intervention assessments to measure changes in depressive symptoms, weight, and psychological well-being. Quantitative measures will include standardised scales assessing depressive symptoms, cognitive function, and weight-related outcomes. Data analysis will involve regression and t-tests to examine interventions’ effects on depression and weight-related outcomes.
Discussion
This study expects to reveal the psychological and physiological mechanisms of the antidepressant effects of Qigong, mindfulness, and low-intensity exercise on obese school children by implementing this study, which will help develop more effective interventions to reduce the incidence of obesity. Ultimately, the findings may improve health outcomes in obese school children and contribute to developing healthcare strategies for this vulnerable population.
Trial registration:
ClinicalTrials.gov ID: NCT03615937.
11 C-methionine in the Diagnostics and Management of Glioblastoma Patients with Rapid Early Progression: Nonrandomized, Open Label, Prospective Clinical Trial (GlioMET)
Authors: Lakomý Radek , Lojová Martina , Souckova Lenka , Hynkova Ludmila , Polachova Katerina , Vasina Jiri , Demlová Regina , Poprach Alexandr , Sana Jiri , Prochazka Tomas , Smrcka Martin , Fadrus Pavel , Jancalek Radim , Selingerova Iveta , Belanova Renata , Slampa Pavel , Pospisil Petr , Kazda Tomas , Demlova Regina 
Published: January 2024

Abstract
Background:
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer. The treatment of GBM consists of a combination of surgery and subsequent oncological therapy, i.e., radiotherapy, chemotherapy, or their combination. If postoperative oncological therapy involves irradiation, magnetic resonance imaging (MRI) is used for radiotherapy treatment planning. Unfortunately, in some cases, a very early worsening (progression) or return (recurrence) of the disease is observed several weeks after the surgery and is called rapid early progression (REP). Radiotherapy planning was based on MRI in all patients. However, patients with REP may benefit from targeting radiotherapy with other imaging modalities. The purpose of the presented clinical trial is to evaluate the utility of 11C-methionine in optimizing radiotherapy for glioblastoma patients with REP.
Methods:
This study is a nonrandomized, open-label, parallel-setting, prospective, monocentric clinical trial. The main aim of this study was to refine the diagnosis in patients with GBM with REP and to optimize subsequent radiotherapy planning.
Glioblastoma patients who develop REP within approximately 6 weeks after surgery will undergo 11C-methionine positron emission tomography (PET/CT) examinations. Target volumes for radiotherapy are defined using both planning T1-weighted contrast-enhanced MRI and PET/CT. The primary outcome is progression-free survival defined using RANO criteria and compared to a historical cohort with REP treated without PET/CT optimization of radiotherapy.
Discussion:
PET is one of the most modern methods of molecular imaging and is a noninvasive in vivo method that allows physicians to study processes in the human body using radiolabelled radiopharmaceuticals. 11C-Methionine is an example of a radiolabelled (carbon 11) amino acid - a source of energy for tumor cells and a building material for new proteins. This radiopharmaceutical is commonly used in the diagnosis of brain tumors and in the evaluation of response to treatment. Optimized radiotherapy may also have the potential to cover those regions with a high risk of subsequent progression, which would not be identified using standard-of-care MRI for radiotherapy planning.
Trial Registration:
NCT05608395, registered on 8.11.2022 in clinicaltrials.gov; EudraCT Number: 2020-000640-64, registered on 26.5.2020 in clinicaltrialsregister.eu. Protocol ID: MOU-2020-01, version 3.2, date 18.09.2020.
Modeling inhibition efficiency of mango leaf extract for corrosion control of mild steel in HCl solution: Response Surface Methodology and Artificial Neural Network
Authors: Omotioma Monday , Onukwuli Okechukwu Dominic , Amaoge Obiora-Okafo Ifeoma , Archibong Friday Nwankwo , Nlemedim Peace Ugochinyerem 
Published: January 2024

Abstract
This study advanced the establishment of natural plant-based inhibitors for corrosion prevention procedures. It entails modelling the efficiency of leaf extract for mild steel corrosion control in HCl solution. The mango leaf extract are characterize to ascertain its molecules/molecular structures using gas chromatography-mass spectrophotometer (GCMS). The efficiency undergo modeling using response surface methodology (RSM) and artificial neural network (ANN). Critical phenomena of the inhibitor’s bio-molecules in the HCl solution and interfacial transition between the molecules and mild steel’s surface are examine using Langmuir, Frumkin, Temkin and Flory-Huggins adsorption isotherms. The results showed that 2-hydroxycyclopentadecanone (C15H28O2), 4-hepten-3-one (C8H14O), benzenemethanol (C9H12O), and 2,7-dimethyloct-7-en-5-yn-4-yl ester (C14H20O4 are the predominant molecular constituents (of higher inhibitive properties) in the mango leaf extract. The highest efficiency of 91.42% is obtain at an inhibition concentration of 0.6 g/L, temperature of 318 K and immersion time of 16 hours. Efficiency of the extract are model by optimization tools of RSM and ANN. Based on statistical analyses (correlation coefficient, RMSE and standard error of prediction), ANN performed better than RSM in the prediction of inhibition efficiency of the extract. Interfacial transition between the extract’s molecules and the mild steel surface established. The bio-molecular constituents inhibited the corrosion by process of adsorption.
Risk factors associated with intraventricular hemorrhage in very-low-birth-weight premature infants
Authors: Puerta-Martínez Alejandra Guadalupe , López-Garrido Esteban , Guerrero-Nava José Miguel , Vargas-Ruiz Rodrigo , Martinez-Padron Hadassa Yuef 
Published: January 2024

Abstract
Purpose
To analyze the association between risk factors and severe intraventricular hemorrhage (Grade II-IV) in PNB under 1500 grams.
Methods
Multicenter, retrospective, analytical, case-control, study in PNB under 34 weeks and under 1500 grams admitted to the NICU Case: PNB with severe intraventricular hemorrhage (grade II-IV). Logistic regression analysis was used to adjust for IVH-associated variables and odds ratios (OR).
Results
A total of 90 PNB files were analyzed, 45 cases and 45 controls. The highest risk factors for severe IVH were lower gestational age (OR:1.3, p < 0.001), perinatal asphyxia (OR:12, p < 0.001), Apgar < 6 at minute 1 and 5 (OR:6.3, p < 0.001).
Conclusion
Lower gestational age, birth asphyxia, Apgar score lower of 6, and respiratory-type factors are associated with increased risk for severe IVH.
Analysis of factors influencing hospitalization cost of patients with distal radius fractures: an empirical study based on public traditional Chinese medicine hospitals in two cities, China
Authors: Chen Mengen , Yang Jingyu , Hou Haojia , Zheng Baozhu , Wu Guoping , Sun Henong , Jia Xuan , Xia Shiji , Wang Yuhan , Yu Jing , Zhang Xiaoxi , Ning Hao , Chang Hui , Yuan Youshu , Wang Zhiwei 
Published: January 2024

Abstract

Background Distal radius fractures (DRFs) have become a public health problem for all countries, bringing a heavier economic burden of disease globally, with China's disease economic burden being even more acute due to the trend of an aging population. This study aimed to explore the influencing factors of hospitalization cost of patients with DRFs in traditional Chinese medicine (TCM) hospitals to provide a scientific basis for controlling hospitalization cost. Methods With 1306 cases of DRFs patients hospitalized in 15 public TCM hospitals in two cities of Gansu Province in China from January 2017 to 2022 as the study object, the influencing factors of hospitalization cost were studied in depth gradually through univariate analysis, multiple linear regression, and path model. Results Hospitalization cost of patients with DRFs is mainly affected by the length of stay, surgery and operation, hospital levels, use of TCM preparations, complications and comorbidities, clinical pathways, and payment methods of medical insurance. The length of stay is the most critical factor influencing the hospitalization cost, and the longer the length of stay, the higher the hospitalization cost. Conclusions TCM hospitals should actively take advantage of TCM diagnostic modalities and therapeutic methods to ensure the efficacy of treatment and effectively reduce the length of stay at the same time, to lower hospitalization cost. It is also necessary to further deepen the reform of the medical insurance payment methods and strengthen the construction of the hierarchical diagnosis and treatment system, to make the patients receive reasonable compensation for medical expenses, thus effectively alleviating the economic burden of the disease in the patients with DRFs.
In vivo mitral valve repair for the transplanted donor heart in orthotopic heart transplantation
Authors: Handa Kazuma , Misumi Yusuke , Yoshioka Daisuke , Kawamura Masashi , Kawamura Takuji , Kawamura Ai , Miyagawa Shigeru 
Published: January 2024

Abstract
A 53-year-old woman with the dilated phase of hypertrophic cardiomyopathy underwent orthotopic heart transplantation. The donor heart was evaluated as normal preoperatively without mitral regurgitation or the left atrium dilation, transplanted using the modified bicaval technique. Although the heart beat satisfactorily after aortic declamping, massive mitral regurgitation was observed without any prolapse or annular dilation. Because of the difficulty in weaning from cardiopulmonary bypass, a second aortic cross-clamp was applied, and we detached the inferior vena cava and the right side of the left atrial anastomosis to approach the mitral valve, obtaining a satisfactory exposure. No abnormalities were observed in the mitral valve leaflets, annulus or subvalvular apparatus. Subsequent in vivo mitral annuloplasty using prosthetic full ring successfully controlled the regurgitation, and the patient was easily weaned from cardiopulmonary bypass. She discharged to home with good mitral valve and cardiac functions.
Integrated Disaster Nursing Response for Public Healthcare Settings in Pakistan: A Sequential Mixed Method Approach Study Protocol
Authors: Gulzar Saleema , Andaleeb Sumia , Jetha Zohra , Qutb Syeda Humera , Saleem Zulekha , Lalani Sharifa , Atiq Huba , Muhammad Shah , Hirani Rimsha , Salman Ahad , Ali Tazeen 
Published: January 2024

Abstract
Background
Natural disasters such as floods, hurricanes, earthquakes, etc. are unforeseen circumstances that overwhelm and affect millions of people. Pakistan is one of the countries which is highly susceptible to getting affected by floods every year. Among the various cities of Pakistan Sanghar and Dadu are the low-lying areas making them vulnerable to being greatly affected by natural disasters. These calamities can cause large human and infrastructure losses, putting the healthcare system's ability to respond effectively at risk. The capacity of healthcare providers to cope with crisis circumstances and offer crucial medical aid is critical to saving lives and minimizing the long-term effects of catastrophic events on human life.
Methods
The study will employ a sequential mixed-method design approach with an embedded experimental component where quantitative and qualitative data are collected and analyzed in two distinct phases respectively. In Phase 1, a Quasi-experimental design will be utilized, consisting of pre-tests and post-tests. The study will be conducted on 310 healthcare providers (155 per district). A nursing post-disaster response capacity-building intervention will be integrated between the pre and post-tests. Phase 2 will involve a qualitative approach, where focus group interviews will be conducted from both areas. These will be analyzed through inductive thematic analysis.
Discussion
This project is anticipated to provide an intervention program to improve healthcare practitioners' disaster response capacities, as well as their ability to deal successfully with catastrophe victims. The role of nurses in disaster response is critical, making this study significant. The findings are expected to have a significant impact on nursing education and practice, particularly in terms of adding disaster nursing response into the nursing curriculum.
Is Cabrol fistula techniques really justified in surgical of aortic disease?
Authors: Han Yaru , Ren Xinglei , Li Ruru , Wang Miao , Jin Jiaqi , Cheng Haoming , Zhong Jiajun , Jiang Nan , Wang Chiyin , Zhang Liqing , Wang Jue 
Published: January 2024

Abstract
Objective: Cabrol fistulas are often used as a bailout procedure in cases of reoperation and severe calcifications in complex aneurysm surgery. However, the justification for using Cabrol fistulas in aortic dissection has been controversial. This study retrospectively evaluated the clinical outcomes of the prophylactic use of Cabrol fistulas.
Methods: The design of this study was a retrospective study. We queried 414 patients with aortic aneurysms or type A aortic dissection who underwent emergency or selective aortic surgery at our center from January 2015 to December 2020 and were followed up until 2022. Among them, 280 patients were treated with the Cabrol fistula (Cabrol group), and 134 patients did not receive this technique (non-Cabrol group). The clinical data of all patients were retrospectively analyzed and followed up.
Results: The 30-day mortality rate of the Cabrol group was higher than that of the non-Cabrol group (n = 29, 10.36% vs n = 7, 5.22%, p < 0.001). The Cabrol group had a lower drainage volume 3 days after surgery (1241 [IQR, 939-1638.5 ml] vs 1480 [IQR, 1245-1725 ml]). There were no significant differences in postoperative complications, BNP levels, CCU stay time, ventilation time, or reoperation (p > 0.05). These outcomes did not appear to differ in subgroup analysis for patients between the two groups.
Conclusions: This study provides evidence that Cabrol fistulas can reduce postoperative drainage. However, patients who underwent Cabrol fistulas had increased 30-day mortality. The Cabrol technique can be used as an emergency measure for aortic surgical bleeding but cannot be used as a routine method.
Construction and validation of a risk prediction model for postoperative ICU admission in patients with colorectal cancer: Clinical prediction model study
Authors: Wang Lu , Wu Yanan , Deng Liqin , Tian Xiaoxia , Ma Junyang 
Published: January 2024

Abstract
Background:
ICU transfer is a common situation after all non-cardiac surgeries, including radical resection of colorectal cancer (CRC). It is important to understand the rational use of expensive ICU medical resources and supportive postoperative treatment. The purpose of this research was to construct and validate a nomogram to predict which patients would need immediate ICU admission after radical CRC resection.
Methods:
Data of 1003 patients who underwent radical resection or palliative surgery for CRC at Ningxia Medical University General Hospital from August 2020 to April 2022 were analyzed retrospectively. Patients were randomly allocated to training and validation queues (7:3, respectively). Using the least absolute shrinkage and selection operator (LASSO) approach and multivariate logistic regression, the nomogram was built by identifying independent predictors in the training cohort. An online prediction tool was generated for clinical application.
Results:
The final predictive model included: age (P = 0.003, odds ratio [OR] 3.623, 95% confidence interval [CI] 1.535–8.551); NRS2002 (P = 0.000, OR 6.129, 95% CI 2.920-12.863); ALB (P = 0.013, OR 0.921, 95% CI 0.863–0.982); atrial fibrillation (P = 0.000, OR 20.017, 95% CI 4.191–95.609); COPD (P = 0.009, OR 8.151, 95% CI 1.674–39.676); FEV1/FVC (P = 0.040, OR 0.966, 95% CI 0.935–0.998); and surgical method (P = 0.024, OR 0.425, 95% CI 0.202–0.891), among others. The nomogram's area under the curve and consistency index were 0.865 and 0.367, respectively. The Hosmer-Lemeshow test revealed that the model fit was excellent (P = 0.367). Predictive performance was confirmed by internal validation.
Conclusion:
Predictors of ICU admission after radical resection of CRC include: age, preoperative serum albumin level, nutritional risk screening, atrial fibrillation, chronic obstructive pulmonary disease, FEV one-second rate, and surgical route. Postoperative ICU admission risk prediction line chart and online web server facilitate clinical decision making on the need for postoperative ICU admission for patients undergoing radical colorectal cancer surgery.
Trial registration:
Despite the retrospective nature of this study, we have proactively registered it with the Chinese Clinical Trial Registry. The registration number is ChiCTR2200062210, and the date of registration is 29/07/2022.