bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Insights Can the Programme Share on Developing Decision Support Tools?
Authors: Perks Rachel , Robson Craig , Arnell Nigel , Cooper James , Dawkins Laura , Fuller Elizabeth , Kennedy-Asser Alan , Nicholls Robert , Ramsey Victoria 
Published: December 2023

Abstract

The definition of decision support tools in the context of climate change and adaptation is explored, highlighting the variation in approaches to design and form of tools.

Several challenges are identified that have impeded the successful development of decision support tools, including financial restrictions, time constraints and meaningful stakeholder engagement.

We highlight a number of potential areas for future research, including work to address the challenges of scaling up decision support tools and stronger frameworks for guiding stakeholder engagement.
Einleitung
Authors: West Nikolai , Klinkenberg Ralf , Deuse Jochen 
Published: December 2023

ZusammenfassungDas BMBF-Forschungsvorhaben AKKORD behandelt die vernetzte und integrierte Anwendung industrieller Datenanalysen für die wertschaffende und kompetenzorientierte Kollaboration in dynamischen Wertschöpfungsnetzwerken. In diesem Kapitel werden die wichtigsten Informationen zum Vorhaben eingeführt. Das übergeordnete Ziel im Forschungsvorhaben stellte die Umsetzung eines integrierten Referenzbaukastens dar, der bausteinartige Teillösungen zur Anwendung industrieller Datenanalysen bereitstellt. Dazu forschten vierzehn Konsortialpartner innerhalb von vier als Leistungsbereichen bezeichneten Teilgebieten. Untersucht wurden die Anwendungen integrierter und vernetzter Datenanalysen mit einem übergreifenden Daten-Backend-System sowie neuartige Möglichkeiten für Kollaborationen und Geschäftsmodelle sowie für die Kompetenzentwicklung und -sicherung. Neben einer Kurzvorstellung der vierzehn Partner werden in diesem Kapitel die vier zentralen Betrachtungsgegenstände des Vorhabens eingeführt und zusammenfassend erläutert. Die Ausführungen ermöglichen einen kompakten Überblick über das gesamte Forschungsvorhaben AKKORD und referenzieren bei Bedarf verwandte Kapitel sowie weiterführende wissenschaftliche Arbeiten.
Industrielle Datenanalysen im Mittelstand
Authors: West Nikolai , Huber Thomas , Deuse Jochen 
Published: December 2023

ZusammenfassungSeit über einem Jahrzehnt erfährt die Forschungslandschaft in Deutschland einen umfassenden Wandel unter dem Einwirken des als Industrie 4.0 bezeichneten Paradigmenwechsels. In diesem Kapitel wird der Hintergrund der Einflussfaktoren und Maßnahmen vorgestellt, die zur Entstehung des Forschungsvorhaben AKKORD beigetragen haben. Das Projekt geht auf eine Initiative der deutschen Bundesregierung vor dem Hintergrund der entwickelten Hightech-Strategie „Innovationen für Deutschland“ zurück. AKKORD beinhaltet acht praktische Anwendungsfälle, die in diesem Kapitel zusammenfassend vorgestellt werden. Ausgehend von den Ergebnissen einer Umfrage werden dann die identifizierten Handlungsbedarfe des produzierenden Gewerbes in Deutschland, und insbesondere des Mittelstandes, diskutiert. Den Abschluss des Kapitels bildet eine Auflistung der konkreten Nutzenvorteile, die sich für Unternehmen durch die Anwendung des im Projekt AKKORD entwickelten Referenzbaukastens zur industriellen Datenanalyse in dynamischen Wertschöpfungsnetzwerken eröffnen. Dieses Kapitel nimmt eine Schlüsselfunktion im zugehörigen Sammelband ein, da es die Ergebnisse aller verbleibenden Kapitel zusammenfassend behandelt und für weiterführende Details referenziert.
Measuring the sterile neutrino mass in spallation source and direct detection experiments
Authors: Alonso-González D. , Amaral D. W. P. , Bariego-Quintana A. , Cerdeño D. , de los Rios M. 
Published: December 2023

Abstract
We explore the complementarity of direct detection (DD) and spallation source (SS) experiments for the study of sterile neutrino physics. We focus on the sterile baryonic neutrino model: an extension of the Standard Model that introduces a massive sterile neutrino with couplings to the quark sector via a new gauge boson. In this scenario, the inelastic scattering of an active neutrino with the target material in both DD and SS experiments gives rise to a characteristic nuclear recoil energy spectrum that can allow for the reconstruction of the neutrino mass in the event of a positive detection. We first derive new bounds on this model based on the data from the COHERENT collaboration on CsI and LAr targets, which we find do not yet probe new areas of the parameter space. We then assess how well future SS experiments will be able to measure the sterile neutrino mass and mixings, showing that masses in the range ~15 − 50 MeV can be reconstructed. We show that there is a degeneracy in the measurement of the sterile neutrino mixing that substantially affects the reconstruction of parameters for masses of the order of 40 MeV. Thanks to their lower energy threshold and sensitivity to the solar tau neutrino flux, DD experiments allow us to partially lift the degeneracy in the sterile neutrino mixings and considerably improve its mass reconstruction down to 9 MeV. Our results demonstrate the excellent complementarity between DD and SS experiments in measuring the sterile neutrino mass and highlight the power of DD experiments in searching for new physics in the neutrino sector.
Wood properties of mature loblolly pine grown in Hawaii, North Carolina, and Mississippi: impacts of climate conditions on specific gravity and chemical composition
Authors: Eberhardt Thomas L. , Kim Keonhee , Labbé Nicole , Samuelson Lisa J. 
Published: December 2023

AbstractHigher productivities for loblolly pine (Pinus taeda L.) growing at exotic locations (e.g., Hawaii, Brazil) indicate that the full growth potential of this southern pine species has yet to be reached in plantations across the southeastern United States (US). The higher productivity of Hawaii-grown loblolly pine has been attributed to more favorable climate conditions. To date, physical, anatomical, and chemical property data for loblolly pine wood from exotic locations are scarce. Mid-infrared spectroscopy coupled with multivariate analysis was used to screen for chemical differences between wood samples from Hawaii (HI), North Carolina (NC), and Mississippi (MS). The principal component analysis scores plot showed that the MS samples formed a distinct cluster apart from overlapping clusters for the other two sites. Using standard wet chemistry procedures, we found that the mean lignin content for the MS site (30.1%) was significantly lower than that determined for the NC (34.5%) and HI (33.9%) sites; said lower lignin value was offset by significantly higher glucose and mannose contents. Results on the US mainland were seemingly consistent with the greater formation of latewood at sites with longer growing seasons, and the lower lignin content of latewood relative to earlywood shown for pines. Given the low percent latewood for the HI site (37.2%) relative to both mainland sites (MS, 54.8%; NC, 53.1%), yet similar lignin contents between the NC and HI sites, it appears that the relative lignin value for these exotically-grown loblolly pine trees cannot be solely attributed to the proportion of latewood.
Impaired glymphatic system revealed by DTI-ALPS in cerebral palsy due to periventricular leukomalacia: relation with brain lesion burden and hand dysfunction
Authors: Yin Yu , Peng Ying , Nie Lisha , Li Xianjun , Xiao Yaqiong , Jiang Haoxiang , Gao Lei , Liu Heng 
Published: December 2023

Abstract
Purpose
Preterm children with cerebral palsy (CP) often have varying hand dysfunction, while the specific brain injury with periventricular leukomalacia (PVL) cannot quite explain its mechanism. We aimed to investigate glymphatic activity using diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and evaluate its association with brain lesion burden and hand dysfunction in children with CP secondary to PVL.

Methods
We retrospectively enrolled 18 children with bilateral spastic CP due to PVL and 29 age- and sex-matched typically developing controls. The Manual Ability Classification System (MACS) was used to assess severity of hand dysfunction in CP. A mediation model was performed to explore the relationship among the DTI-ALPS index, brain lesion burden, and the MACS level in children with CP.

Results
There were significant differences in the DTI-ALPS index between children with CP and their typically developing peers. The DTI-ALPS index of the children with CP was lower than that of the controls (1.448 vs. 1.625, P = 0.003). The mediation analysis showed that the DTI-ALPS index fully mediated the relationship between brain lesion burden and the MACS level (c′ = 0.061, P = 0.665), explaining 80% of the effect.

Conclusion
This study provides new insights into the neural basis of hand dysfunction in children with CP, demonstrating an important role of glymphatic impairment in such patients. These results suggest that PVL might affect hand function in children with CP by disrupting glymphatic drainage.
Prediction of therapy response of breast cancer patients with machine learning based on clinical data and imaging data derived from breast [18F]FDG-PET/MRI
Authors: Jannusch Kai , Dietzel Frederic , Bruckmann Nils Martin , Morawitz Janna , Boschheidgen Matthias , Minko Peter , Bittner Ann-Kathrin , Mohrmann Svjetlana , Quick Harald H. , Herrmann Ken , Umutlu Lale , Antoch Gerald , Rubbert Christian , Kirchner Julian , Caspers Julian 
Published: December 2023

Abstract
Purpose
To evaluate if a machine learning prediction model based on clinical and easily assessable imaging features derived from baseline breast [18F]FDG-PET/MRI staging can predict pathologic complete response (pCR) in patients with newly diagnosed breast cancer prior to neoadjuvant system therapy (NAST).

Methods
Altogether 143 women with newly diagnosed breast cancer (54 ± 12 years) were retrospectively enrolled. All women underwent a breast [18F]FDG-PET/MRI, a histopathological workup of their breast cancer lesions and evaluation of clinical data. Fifty-six features derived from positron emission tomography (PET), magnetic resonance imaging (MRI), sociodemographic / anthropometric, histopathologic as well as clinical data were generated and used as input for an extreme Gradient Boosting model (XGBoost) to predict pCR. The model was evaluated in a five-fold nested-cross-validation incorporating independent hyper-parameter tuning within the inner loops to reduce the risk of overoptimistic estimations. Diagnostic model-performance was assessed by determining the area under the curve of the receiver operating characteristics curve (ROC-AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy. Furthermore, feature importances of the XGBoost model were evaluated to assess which features contributed most to distinguish between pCR and non-pCR.

Results
Nested-cross-validation yielded a mean ROC-AUC of 80.4 ± 6.0% for prediction of pCR. Mean sensitivity, specificity, PPV, and NPV of 54.5 ± 21.3%, 83.6 ± 4.2%, 63.6 ± 8.5%, and 77.6 ± 8.1% could be achieved. Histopathological data were the most important features for classification of the XGBoost model followed by PET, MRI, and sociodemographic/anthropometric features.

Conclusion
The evaluated multi-source XGBoost model shows promising results for reliably predicting pathological complete response in breast cancer patients prior to NAST. However, yielded performance is yet insufficient to be implemented in the clinical decision-making process.
Potential radiation dose reduction in clinical photon-counting CT by the small pixel effect: ultra-high resolution (UHR) acquisitions reconstructed to standard resolution
Authors: Fix Martinez Markel , Klein Laura , Maier Joscha , Rotkopf Lukas Thomas , Schlemmer Heinz-Peter , Schönberg Stefan Oswald , Kachelrieß Marc , Sawall Stefan 
Published: December 2023

Abstract
Objective
To assess the potential dose reduction achievable with clinical photon-counting CT (PCCT) in ultra-high resolution (UHR) mode compared to acquisitions using the standard resolution detector mode (Std).

Materials and methods
With smaller detector pixels, PCCT achieves far higher spatial resolution than energy-integrating (EI) CT systems. The reconstruction of UHR acquisitions to the lower spatial resolution of conventional systems results in an image noise and radiation dose reduction. We quantify this small pixel effect in measurements of semi-anthropomorphic abdominal phantoms of different sizes as well as in a porcine knuckle in the first clinical PCCT system by using the UHR mode (0.2 mm pixel size at isocenter) in comparison to the standard resolution mode (0.4 mm). At different slice thicknesses (0.4 up to 4 mm) and dose levels between 4 and 12 mGy, reconstructions using filtered backprojection were performed to the same target spatial resolution, i.e., same modulation transfer function, using both detector modes. Image noise and the resulting potential dose reduction was quantified as a figure of merit.

Results
Images acquired using the UHR mode yield lower noise in comparison to acquisitions using standard pixels at the same resolution and noise level. This holds for sharper convolution kernels at the spatial resolution limit of the standard mode, e.g., up to a factor 3.2 in noise reduction and a resulting potential dose reduction of up to almost 90%.

Conclusion
Using sharper convolution kernels, UHR acquisitions allow for a significant dose reduction compared to acquisitions using the standard detector mode.

Clinical relevance
Acquisitions should always be performed using the ultra-high resolution detector mode, if possible, to benefit from the intrinsic noise and dose reduction.

Key Points
• Ionizing radiation used in computed tomography examinations is a concern to public health.
• The ultra-high resolution of novel photon-counting systems can be invested towards a noise and dose reduction if only a spatial resolution below the resolution limit of the detector is desired.
• Acquisitions should always be performed in ultra-high resolution mode, if possible, to benefit from an intrinsic dose reduction.
Correlation analysis of feeding intolerance and defecation after primary anastomosis for neonatal intestinal atresia
Authors: Zhou Ling , Chen Yang , Wang Zhiyong , Chu Dongdong , Xiao Dong , Zhu Ledao , Guan Aihui , Liao Qianghui , Liu Jiashu , Li Jiahui , Ren Feng 
Published: December 2023

Abstract
Purpose
To investigate the correlation between postoperative feeding intolerance and defecation, with a view to carrying out prognostic assessment and timely intervention for the recovery of postoperative gastrointestinal function.

Methods
The 114 neonates with congenital intestinal atresia who underwent primary anastomosis admitted to Shenzhen Children's Hospital from January 2014 to December 2022 were studied, and the patients' basic information, intraoperative conditions, postoperative feeding and defecation, and hospitalization time were retrospectively analyzed.

Results
The risk factors for feeding intolerance after primary anastomosis for intestinal atresia are the gestational days, the time of the first postoperative defecations, the number of defecations on the previous day and the average number of defecations before feeding.

Conclusion
The incidence of postoperative feeding intolerance is higher in preterm infants, and pediatricians can decide the timing of breastfeeding on the basis of the patients’ defecation. The focus on accurate defecation may be more meaningful in determining and predicting postoperative feeding intolerance in the infants.
Cytokine profile levels and their relationship with parasitemia and cardiomyopathy in people with Chagas disease in Spain. A prospective observational study
Authors: Ramos-Rincon Jose-Manuel , Torrús-Tendero Diego , García-Morante Hilarion , Gimeno-Gascón Adelina , Marco Francisco , Gil-Anguita Concepción , Wikman-Jorgensen Philip , Lucas-Dato Ana , Rodriguez-Diaz Juan-Carlos , Amador Concepción , Llenas-García Jara 
Published: December 2023

AbstractImmunoregulatory networks may have a role in controlling parasitemia in the chronic phase of human Chagas disease. The aim was to describe the serum cytokine profile of Trypanosoma cruzi in chronically infected patients and to evaluate its relationship with parasitemia and Chagas cardiomyopathy.This prospective observational study included adult patients with chronic Chagas disease. Demographic and clinical data were collected, and peripheral blood samples were used to perform T. cruzi real-time polymerase chain reaction (RT-PCR) and determine the serum cytokine profile.Fifty-eight patients were included; 17 (29.3%) had positive RT-PCR results. This group had a higher median concentration of TNF-α (p = 0.003), IL-6 (p = 0.021), IL-4 (p = 0.031), IL-1β (p = 0.036), and IL-17A (p = 0.043) than those with a negative RT-PCR. Patients with cardiac involvement had a higher median concentration of IL-5 (p = 0.016) than those without.These results reinforce the key role that cytokines play in Chagas disease patients with parasitemia and cardiac involvement.
Lipschitz regularity for solutions of a general class of elliptic equations
Authors: Marino Greta , Mosconi Sunra 
Published: December 2023

AbstractWe prove local Lipschitz regularity for local minimisers of$$\begin{aligned} W^{1,1}(\Omega )\ni v\mapsto \int _\Omega F(Dv)\, dx \end{aligned}$$W1,1(Ω)∋v↦∫ΩF(Dv)dxwhere$$\Omega \subseteq {\mathbb {R}}^N$$Ω⊆RN,$$N\ge 2$$N≥2and$$F:{\mathbb {R}}^N\rightarrow {\mathbb {R}}$$F:RN→Ris a quasiuniformly convex integrand in the sense of Kovalev and Maldonado (Ill J Math 49:1039–1060, 2005), i. e. a convex$$C^1$$C1-function such that the ratio between the maximum and minimum eigenvalues of$$D^2F$$D2Fis essentially bounded. This class of integrands includes the standard singular/degenerate functions$$F(z)=|z|^p$$F(z)=|z|pfor any$$p>1$$p>1and arises as the closure, with respect to a natural convergence, of the strongly elliptic integrands of the Calculus of Variations.
On the GIT-Stability of Foliations of Degree 3 with a Unique Singular Point
Authors: Castorena Abel , Pantaleón-Mondragón P. Rubí , Vásquez Aquino Juan 
Published: December 2023

AbstractApplying Geometric Invariant Theory (GIT), we study the stability of foliations of degree 3 on $$\mathbb {P}^{2}$$

P

2

with a unique singular point of multiplicity 1, 2, or 3 and Milnor number 13. In particular, we characterize those foliations for multiplicity 2 in three cases: stable, strictly semistable, and unstable.
Verbal and non-verbal recognition memory assessment: validation of a computerized version of the Recognition Memory Test
Authors: Baruzzo Elena , Terruzzi Stefano , Feder Beatrice , Papagno Costanza , Smirni Daniela 
Published: December 2023

Abstract
Background
The use of computerized devices for neuropsychological assessment (CNADs) as an effective alternative to the traditional pencil-and-paper modality has recently increased exponentially, both in clinical practice and research, especially due to the pandemic. However, several authors underline that the computerized modality requires the same psychometric validity as "in-presence" tests. The current study aimed at building and validating a computerized version of the verbal and non-verbal recognition memory test (RMT) for words, unknown faces and buildings.

Methods
Seventy-two healthy Italian participants, with medium–high education and ability to proficiently use computerized systems, were enrolled. The sample was subdivided into six groups, one for each age decade. Twelve neurological patients with mixed aetiology, age and educational level were also recruited. Both the computerized and the paper-and-pencil versions of the RMT were administered in two separate sessions.

Results
In healthy participants, the computerized and the paper-and-pencil versions of the RMT showed statistical equivalence for words, unknown faces and buildings. In the neurological patients, no statistical difference was found between the performance at the two versions of the RMT. A moderate-to-good inter-rater reliability between the two versions was also found in both samples. Finally, the computerized version of the RMT was perceived as acceptable by both healthy participants and neurological patients at System Usability Scale (SUS).

Conclusion
The computerized version of the RMT can be used as a reliable alternative to the traditional version.
Stillbirth of a mandrill (Mandrillus sphinx) in the wild: perinatal behaviors and delivery sequences
Authors: Roura-Torres Berta , Amblard-Rambert Paul , Lepou Pascal , Kappeler Peter M. , Charpentier Marie J. E. 
Published: December 2023

AbstractBirth is a fundamental event in the life of animals, including our own species. More reports of wild non-human primate births and stillbirths are thus needed to better understand the evolutionary pressures shaping parturition behaviors in our lineage. In diurnal non-human primates, births generally occur at night, when individuals are resting. Consequently, they are difficult to observe in the wild and most of the current knowledge regarding perinatal behaviors comes from rare daytime births. Information about stillbirths is even rarer and their proximate causes are generally unknown. Here, we present detailed observations of a daytime birth of a stillborn wild mandrill (Mandrillus sphinx). During this event, which lasted an entire day, we recorded the behaviors of the parturient female ad libitum, using video recordings and photos. The 5-year-old female was primiparous and of low dominance rank. The length of her pregnancy was shorter than usual and the partum phase was extremely long compared to other birth reports in non-human primates. The female disappeared shortly after this event and was assumed to have died. We discuss the possible causes of this stillbirth including the infant’s presentation at birth and maternal inexperience.
Influence of Epoxy Spray Binder on Infusion and Cure in Liquid Composite Molding Processes
Authors: Möllers Hendrik , Schmidt Carsten , Meiners Dieter 
Published: December 2023

AbstractBinders are known to influence the different steps in liquid composite molding process chains. Most reseach focuses on powder binder and veils. Spray binders are rarely studied. Therefore, the effect of an epoxy spray binder on the infusion and cure steps of liquid composite molding processes is studied in this paper. Permeability measurements, solubility tests and measurements of glass transition temperature, resin cure time and resin viscosity show a complex interaction between binder and resin depending on the process conditions. The binder mostly increased the permeability of the tested preforms. This effect increases with increasing binder loading. At low fiber volume fractions the binder had a positive effect on preform permeability, most likely by to delaying the closure of macro flow channels or textile inhomogeneity. The binder did not dissolve in the resin until temperatures of around 120 °C, while remaining as a separate phase at 22 °C, 40 and 80 °C. This has to be considered when defining the cure profile of the resin, as the binder is expected to participate in the cure reaction. The glass transition temperature remained unchanged for the binder-resin combination used. An increase in viscosity by a factor of 1.5-2 was observed when the binder was dissolved in the resin. Samples with dissolved binder cured slightly faster than pure resin. The experimental results were theoretically transferred to real infusion processes.