bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of extended-spectrum β-lactamase–producing Enterobacterales infection in kidney transplant recipients
Authors: Promsuwan Oranuch , Malathum Kumthorn , Ingsathit Atiporn 
Published: November 2023

Abstract
Background
Extended-spectrum b-lactamase (ESBL)-producing gram-negative bacilli (ESBL-GNB) are the most important pathogenic bacteria infecting kidney transplant patients. Kidney transplantation has been shown to be a risk factor for nosocomial ESBL-GNB bacteremia. The aims of this study were to describe the epidemiology of ESBL-GNB acquisition and to identify factors associated with ESBL-GNB infection in kidney transplant recipients, including pretransplant ESBL-GNB fecal carriage.

Methods
A prospective study of patients undergoing kidney transplantation at Ramathibodi Hospital from March 1, 2019–November 30, 2020 was conducted. During this period, 66 patients who underwent kidney transplantation. Perianal swab cultures and urine cultures for ESBL-GNB were obtained from all subjects upon admission for transplantation and on Days 3, 7, 14 and 21 after surgery to determine the prevalence, incidence, and duration of admission before acquisition of the organisms.

Results
Of the 66 patients undergoing kidney transplantation, 18 preoperative perianal swabs were detected to be positive for ESBL-GNB upon admission, representing 27.3% of the cases. The in-hospital perianal swab tests showed a significant increase to 96.8% positive ESBL-GNB cultures at the end of week 3. Approximately one-fourth (27.8%) of patients who acquired ESBL-GNB developed a postoperative symptomatic infection. The infection occurred in 13% of such patients who were not ESBL positive at first. These infections included urinary tract infections (20 cases, [30%], of which 55% were due to ESBL-GNB) and bloodstream infections (13 cases; of which 9 [69.2%] were due to ESBL-GNB). E. coli was the most common pathogen. Previous exposure to antibiotics, including surgical prophylaxis, underlying disease, duration of indwelling urinary catheters and ureteric stents, as well as other operative factors were not found to be significantly associated with the acquisition of ESBL-producing organisms in this dataset.

Conclusions
ESBL carriage may be a risk factor for the development of bacteremia and other serious infections among kidney transplant recipients, although a statistically significant difference could not be demonstrated owing to the small size of the sample. The high rate of ESBL acquisition suggests that more stringent infection prevention and control efforts are needed.
Exploring the association between triglyceride-glucose index and thyroid function
Authors: Cheng Hui , Hu Yanyan , Zhao Haoran , Zhou Guowei , Wang Gaoyuan , Ma Chaoqun , Xu Yan 
Published: November 2023

Abstract
Background
Thyroid dysfunction is associated with abnormal glucose-insulin homeostasis, and the triglyceride-glucose (TyG) index has been recommended as a convenient surrogate of insulin resistance (IR). This study aimed to investigate the relationship between TyG and thyroid function in the US population.

Methods
We analyzed data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2007 to 2012 in a cross-sectional manner. Aside from conventional thyroid parameters, our study evaluated the central sensitivity to thyroid hormones (THs) using the thyroid feedback quantile-based index (TFQI), thyrotropin resistance index (TT4RI), and thyrotropin index (TSHI). To evaluate peripheral sensitivity to THs, we calculated the ratio of free triiodothyronine (FT3) to free thyroxine (FT4) and the sum activity of peripheral deiodinases (SPINA-GD). In the 1848 adults, multivariable linear regression, subgroup, and interaction analyses were employed to estimate the association between TyG and thyroid parameters. The nonlinear relationship was addressed by smooth curve fittings and generalized additive models.

Results
After adjusting covariates, we demonstrated a significant negative association between TyG and FT4 (β = − 0.57, p < 0.001), and a positive relationship between TyG and thyroid-stimulating hormone (β = 0.34, p = 0.037), as well as TgAb (β = 17.06, p = 0.005). Subgroup analysis indicated that the association between TyG and TgAb was more pronounced in the female subjects (β = 32.39, p < 0.001, p for interaction = 0.021). We also confirmed an inverse correlation between TyG and central sensitivity to THs, as assessed by TSHI and TT4RI (βTSHI = 0.12, p < 0.001; βTT4RI = 2.54, p = 0.023). In terms of peripheral sensitivity to THs, we found a significant positive correlation between TyG and FT3/FT4 (β = 0.03, p = 0.004), and SPINA-GD (β = 2.93, p = 0.004).

Conclusion
The present study established a noteworthy association between TyG and thyroid parameters, indicating a strong link between IR and thyroid dysfunction. Further investigations are warranted to validate these results.
The impact of IFRS mandate and institutional governance on underpricing and aftermarket performance of IPO shares in Turkey
Authors: Azimli Asil 
Published: November 2023

AbstractAlong with the European Union, policymakers in Turkey passed a regulation that mandated all listed companies use the International Financial Reporting Standards (IFRS) starting from January 1, 2005. Using a before-after estimation design, this study examines the impact of this policy change and the role of institutional governance quality on the initial trading day and aftermarket trading performance of initial public offerings (IPO) in Turkey from 1998 to 2019. The results show that the IFRS mandate does not affect initial trading day returns but improves the aftermarket trading performance of IPO shares. This finding may imply that Turkey’s secondary market also suffers from information asymmetry and that IFRS-compliant reports help alleviate this problem. Furthermore, none of the six institutional governance quality measures tested loaded significantly against initial trading day or long-term returns. However, when examined together, two institutional measures with a negative value, voice and accountability, and political stability, offset the positive effect of the IFRS-compliant reporting on long-term IPO returns, providing support to the premise that institutional quality matters for realizing the economic benefits of the IFRS mandate.
Image calibration in choroidal vascularity index measurement
Authors: Shariati Mehrdad Motamed , Shoeibi Nasser 
Published: November 2023

AbstractChoroid is a tissue with a very high blood flow which is a metabolic supporter of the retina. Recently, the study of choroidal blood flow in ocular and systemic disorders is a hot topic in scientific research. With the advent of enhanced depth imaging OCT (EDI-OCT), it is possible to measure the entire choroidal thickness. The choroidal vascularity index (CVI) is a relatively new index in studying choroidal hemodynamics. However, the CVI measurement needs image processing. Image calibration is a necessary step before any image processing with software such as ImageJ.
From safety net to trampoline: elevating learning with growth mindset in healthcare simulation
Authors: Hopkins Samantha Rae , Rae Valerie Isobel , Smith Samantha E. , Meldrum Stephen , Tallentire Victoria R. 
Published: November 2023

AbstractThe Implicit Theory of Mindset proposes two different mindsets that sit at opposite ends of a spectrum: a fixed mindset versus a growth mindset. With a fixed mindset, an individual believes they are born with a certain amount of an attribute, and so their potential is both pre-determined and static. With a growth mindset, an individual believes their attributes are malleable and can strengthen over time with repeated effort, adaptable learning strategies, and challenge seeking. Adoption of a growth mindset is associated with improved academic success, more effective learning strategies, increased resilience in the face of adversity, and better mental wellbeing.The theoretical underpinning of psychological safety resonates with the Implicit Theory of Mindset as it infers that a significant number of simulation participants have a fixed mindset and are therefore more likely to be fearful of making an error. The simulation community agree that participants need to feel comfortable making errors for simulation to be successful. The key word here is comfortable. Participants feeling comfortable to make errors just scratches the surface of adopting a growth mindset. With a growth mindset, participants see errors as a positive in the simulation experience, an inevitability of the learning process, evidence that they are adequately challenging themselves to improve.Encouraging adoption of a growth mindset in participants is a powerful addition to the establishment of psychological safety because a growth mindset will re-frame participants’ experiences of social comparison from negative to positive and optimize information processing. We propose a novel idea: simulation educators should be explicit in the pre-brief about what a growth mindset is and its associated benefits to encourage its adoption during the simulation activity—a simulation growth mindset intervention. If this is not possible due to time constraints, an online module or article about growth mindset would be appropriate as pre-reading to encourage adoption of a growth mindset in participants. The message is not that a simulation growth mindset intervention should replace the focus on psychological safety but rather that it should be used synergistically to provide the highest quality simulation experience.
The Curies’ element: state of the art and perspectives on the use of radium in nuclear medicine
Authors: Franchi Sara , Asti Mattia , Di Marco Valerio , Tosato Marianna 
Published: November 2023

Abstract
Background
The alpha-emitter radium-223 (223Ra) is presently used in nuclear medicine for the palliative treatment of bone metastases from castration-resistant prostate cancer. This application arises from its advantageous decay properties and its intrinsic ability to accumulate in regions of high bone turnover when injected as a simple chloride salt. The commercial availability of [223Ra]RaCl2 as a registered drug (Xofigo®) is a further additional asset.

Main body
The prospect of extending the utility of 223Ra to targeted α-therapy of non-osseous cancers has garnered significant interest. Different methods, such as the use of bifunctional chelators and nanoparticles, have been explored to incorporate 223Ra in proper carriers designed to precisely target tumor sites. Nevertheless, the search for a suitable scaffold remains an ongoing challenge, impeding the diffusion of 223Ra-based radiopharmaceuticals.

Conclusion
This review offers a comprehensive overview of the current role of radium radioisotopes in nuclear medicine, with a specific focus on 223Ra. It also critically examines the endeavors conducted so far to develop constructs capable of incorporating 223Ra into cancer-targeting drugs. Particular emphasis is given to the chemical aspects aimed at providing molecular scaffolds for the bifunctional chelator approach.
Loss distribution analysis and accurate calculation method for bulk-power MMC
Authors: Song Yonghui , Luo Yongjie , Xiong Xiaofu 
Published: November 2023

AbstractAccurate evaluation of power losses in a modular multilevel converter (MMC) is very important for circuit component selection, cooling system design, and reliability analysis of power transmission systems. However, the existing converter valve loss calculation methods using the nearest level modulation (NLM) method and the traditional sorting-based capacitor voltage balancing strategy are inaccurate since the submodule (SM) switching logics in the MMC arms are uncertain. To solve this problem, the switching principle of the SMs in the sorting-based voltage balancing strategy is analyzed. An accurate MMC power loss calculation method based on the analysis of loss distribution of various SM topologies, including half-bridge submodule (HBSM), full-bridge submodule (FBSM) and clamp double submodule (CDSM), is proposed in this paper. The method can accurately calculate the losses caused by the extra switching actions during the capacitor voltage balancing process, thus greatly increasing the calculation accuracy of switching losses compared with existing methods. Simulation results based on a practical ± 350 kV/1000 MW MMC-HVDC system with variety of MMC topologies with different voltage balancing strategies demonstrate the effectiveness of the proposed method.
Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea
Authors: Koriem Khaled M. M. , Abdeen Alaa M. A. 
Published: November 2023

Abstract
Background
Diarrhea is the increase of excretion of human water content and an imbalance in the physiologic processes of the small and large intestine while shikimic acid is an important biochemical metabolite in plants. This study aims to study the anti-diarrheal activity of shikimic acid through restoring kidney function, antioxidant activity, inflammatory markers, sodium/potassium-ATPase activity, apoptosis genes, and histology of the kidney in SD rats fed lactose diet to induce diarrhea.

Results
Thirty-six male SD rats (150 ± 10 g, 12 weeks old) were divided into 2 equal groups (18 rats/group) as follows: normal and diarrheal rats. Normal rats were divided into 3 equal groups of 6 rats each: the control, shikimic acid, and desmopressin drug groups. Diarrheal rats were also divided into 3 equal groups of 6 rats each: diarrheal, diarrheal rats + shikimic acid, and diarrheal rats + desmopressin drug groups. Shikimic acid restored serum urea and creatinine, urinary volume, kidney weight, sodium, potassium, and chloride balance in serum and urine. The acid returned the antioxidant (superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, NADPH oxidase activity, conjugated dienes, and oxidative index) activity and the inflammatory markers (tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-10) to values approaching the control values. Shikimic acid also restored the sodium/potassium-ATPase activity, the apoptosis genes p53 and bcl-2, and the histology of kidney tissue in diarrheal rats to be near the control group.

Conclusions
Shikimic acid rescues diarrhea and its complications through restoring kidney function, serum and urinary electrolytes, antioxidant activity, inflammatory markers, sodium/potassium-ATPase activity, the apoptosis genes, and the histology of the kidney in diarrheal rats to approach the control one.
Holistic multiphysics simulation of climatic responses of cold region pavements
Authors: Jiang Yusheng , Yu Xiong 
Published: November 2023

AbstractIn cold regions, the environment dynamics lead to variations of soil temperature, water content, and deformation, which are characterized by highly coupled physical interplay. The hydraulic and thermal properties of unsaturated soils are highly nonlinear, which is further complicated when subjected to freezing. This paper presents a comprehensive multiphysics coupling model to evaluate these complex processes. The model considers the behaviors of unsaturated frozen soils. It accounts for the influences of meteorological, geothermal, and hydrological factors. The model is validated through two pavement case studies using Long-Term Pavement Performance (LTPP) road section data. The first case analysis is performed for a pavement section in Vermont, and the simulation lasted for 30 days during a non-freezing season on an hourly basis. The results validated the performance of the model considering unsaturated soil behaviors. The second case study is based on a daily analysis of a pavement section in South Dakota over a freezing–thawing cycle over 194 days. The results validated the model in considering the frozen unsaturated soil behaviors. Both case studies demonstrate the performance of this comprehensive model in quantifying the spatial and temporal variations of soil temperature and water content in response to environmental stressors. The capability of the model in accurately predicting the responses of pavement to the meteorological factors unleashes the potential of this model to assess the effects of climate and climate change on cold region pavement, as well as other types of geo-structures.
Media Picture of the World as an Object of Academic Study
Authors: Dobrosklonskaya T. , Lomakin B. 
Published: November 2023

The purpose of the article is to consider the formation, development and modern approaches to the study of one of the key concepts for media research — the media picture of the world. The relevance of the study is due to the growing influence of media representation of events formed by the media with the help of linguomedia construction technologies on public consciousness and behavior. The study of the media picture of the world as an object of scientific description is based on an integrative approach,
including its consideration in a historical perspective, analysis of various approaches to definition, as well as a review of modern theories and methods of study. Particular attention is paid to the historical and philosophical roots of the modern interpretation of the concept of “media picture of the world”, domestic research in this area, as well as methods of modeling the modern media picture of the world, which allows us to analyze the processes of formation of media images in dynamics. As a result of the study, the key properties of the media picture of the world are highlighted, such as:the media picture of the world is an open nonlinear dynamic system that has both a holistic and mosaic character; The media picture of the world,formed by national media, reflects and reproduces the sociocultural specifics of a certain civilizational community and region.
Survivorship and risk factors for revision of metal-on-metal hip resurfacing
Authors: Subbiah Ponniah Hariharan , Logishetty Kartik , Edwards Thomas C. , Singer Gian C. 
Published: November 2023

AimsMetal-on-metal hip resurfacing (MoM-HR) has seen decreased usage due to safety and longevity concerns. Joint registries have highlighted the risks in females, smaller hips, and hip dysplasia. This study aimed to identify if reported risk factors are linked to revision in a long-term follow-up of MoM-HR performed by a non-designer surgeon.MethodsA retrospective review of consecutive MoM hip arthroplasties (MoM-HRAs) using Birmingham Hip Resurfacing was conducted. Data on procedure side, indication, implant sizes and orientation, highest blood cobalt and chromium ion concentrations, and all-cause revision were collected from local and UK National Joint Registry records.ResultsA total of 243 hips (205 patients (163 male, 80 female; mean age at surgery 55.3 years (range 25.7 to 75.3)) with MoM-HRA performed between April 2003 and October 2020 were included. Mean follow-up was 11.2 years (range 0.3 to 17.8). Osteoarthritis was the most common indication (93.8%), and 13 hips (5.3%; 7M:6F) showed dysplasia (lateral centre-edge angle < 25°). Acetabular cups were implanted at a median of 45.4° abduction (interquartile range 41.9° - 48.3°) and stems neutral or valgus to the native neck-shaft angle. In all, 11 hips (4.5%; one male, ten females) in ten patients underwent revision surgery at a mean of 7.4 years (range 2.8 to 14.2), giving a cumulative survival rate of 94.8% (95% confidence interval (CI) 91.6% to 98.0%) at ten years, and 93.4% (95% CI 89.3% to 97.6%) at 17 years. For aseptic revision, male survivorship was 100% at 17 years, and 89.6% (95% CI 83.1% to 96.7%) at ten and 17 years for females. Increased metal ion levels were implicated in 50% of female revisions, with the remaining being revised for unexplained pain or avascular necrosis.ConclusionThe Birmingham MoM-HR showed 100% survivorship in males, exceeding the National Institute for Health and Care Excellence ‘5% at ten years’ threshold. Female sex and small component sizes are independent risk factors. Dysplasia alone is not a contraindication to resurfacing.Cite this article: Bone Jt Open 2023;4(11):853–858.
2π ambiguity-free digital holography method for stepped phase imaging: erratum
Authors: Zhang Duo , Li Tuo , Lei Wenxiu , Zhang Qian , Wang Shuai , Dong Jun 
Published: November 2023

We present an erratum to J. Opt. Soc. Am. A, 39, 2376 (2022)JOAOD60740-323210.1364/JOSAA.476200. This erratum adds the mathematical proof of the unique solution of Eq. (3) in Appendix A. At the same time, we correct an unintended error in which the phase step in Fig. 3(a2) and Fig. 4(a2) did not exceed 2π. The signal-to-noise ratio (SNR) required in the proposed method is related to the step size. We analyze the required SNR under different step sizes and find that the smaller the step size, the higher the SNR that is required.
Maternal varicella antibodies in children aged less than one year: Assessment of antibody decay
Authors: Bolotin Shelly , Hughes Stephanie L. , Savage Rachel D. , McLachlan Elizabeth , Severini Alberto , Arnold Callum , Richardson Susan , Crowcroft Natasha S. , Deek Shelley , Halperin Scott A. , Brown Kevin A. , Hatchette Todd , Osman Selma , Gubbay Jonathan B. , Science Michelle 
Published: November 2023

Objectives
To investigate maternal antibody levels to varicella in infants <12 months of age in Ontario, Canada.

Study design
In this study, we included specimens from infants <12 months of age, born at ≥37 weeks gestational age, who had sera collected at The Hospital for Sick Children (Toronto, Canada) between 2014–2016. We tested sera using a glycoprotein-based enzyme-linked immunosorbent assay (gpELISA). We measured varicella susceptibility (antibody concentration <150mIU/mL) and mean varicella antibody concentration, and assessed the probability of susceptibility and concentration between one and 11 months of age using multivariable logistic regression and Poisson regression.

Results
We found that 32% of 196 included specimens represented infants susceptible to varicella at one month of age, increasing to nearly 80% at three months of age. At six months of age, all infants were susceptible to varicella and the predicted mean varicella antibody concentration declined to 62 mIU/mL (95% confidence interval 40, 84), well below the threshold of protection.

Conclusions
We found that varicella maternal antibody levels wane rapidly in infants, leaving most infants susceptible by four months of age. Our findings have implications for the timing of first dose of varicella-containing vaccine, infection control measures, and infant post-exposure prophylaxis recommendations.