bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ‘take‐5 theatre brief’: Group mindfulness practice for operating theatre teams
Authors: Schuster‐Bruce James , Crossley Eleanor , Peters David , Sathyanath Ananth , Rajasingam Daghni , Shylaja Venu , Syed Irfan , Lakhani Raj 
Published: January 2024

AbstractBackgroundA surgical team works in a high‐performance environment and is exposed to stress. Mindfulness practice is evidenced to reduce symptoms of stress, as well as burnout, which is high amongst health workers. The operating theatre is unique, with many job‐roles, needs and time‐critical tasks. It is plausible that group mindfulness may benefit the surgical team. This evaluates the take‐5 theatre brief, consisting of a ‘check‐in’ and short breathwork, when used by two surgical teams as part of the regular theatre team brief.ApproachThe take‐5 theatre brief was evaluated using domains of acceptability and implementation. Data were collected at two district general hospitals in the United Kingdom using 5‐point Likert scales hosted on electronic surveys Thematic analysis was performed of participant voice notes, strategic meeting notes and transcripts of interviews between key informants.EvaluationThere were 17 participants. Ten were from site A (59%), with the remainder being from site B (41%) and covered a range of roles within the theatre team. Participants found the take‐5 theatre brief helpful (median Likert 5) and felt that it would benefit themselves (median Likert 5) as well as the team (median Likert 5) and that it fitted into the day easily (median Likert 4). There was a high demand, no financial investment was required and overall it was easy to implement; however, it became challenged in theatre lists that were late to start.ImplicationThe take‐5 theatre brief is an acceptable initiative for these two operating theatre teams.
How does multi‐modal travel enhance tourist attraction accessibility? A refined two‐step floating catchment area method using multi‐source data
Authors: Zhang Yongqi , Fu Xiao , Yu Zhaoyuan , Luo Shuli 
Published: January 2024

AbstractIn the post‐pandemic era, tourism has emerged as the most popular form of recreation in densely populated areas, driven by the pursuit of improved quality of life and the younger generation's growing enthusiasm for connecting with nature or history. Accurate measurement of the accessibility of tourist attractions has become crucial due to this trend. However, existing methods for measuring accessibility, such as the widely used two‐step floating catchment area (2SFCA) method, show limitations in multi‐modal transport networks as it overlooks multi‐modal travels and assumes uniform access for each transport mode within the catchment area. In this article, we present a novel multi‐modal network‐based two‐step floating catchment area (MMN‐2SFCA) method, which incorporates a super‐network to explicitly model the multi‐modal travels. The proposed method emphasizes the modeling of transfer behavior, resulting in a more comprehensive and accurate measurement of tourist attraction accessibility compared to the conventional 2SFCA method. The proposed method emphasizes the modeling of transfer behavior, travel mode choice, and travel demand estimation by multi‐source big data (including mobile phone signaling data, travel survey data, subway smart card data, and bike‐sharing data), resulting in a more comprehensive and accurate measurement of tourist attraction accessibility compared to the conventional 2SFCA method. The results of the case study in Suzhou (a famous tourism city in China) demonstrate the effectiveness of the proposed MMN‐2SFCA method. The method can rectify the imbalance in accessibility distribution caused by considering only single‐modal trips, and avoid overestimation of accessibility by accounting for transfer behavior. This study contributes to advancing accessibility measurement for multi‐modal transport networks. Moreover, the MMN‐2SFCA method offers excellent extensibility, enabling authorities to optimize and coordinate multi‐modal transport networks for improving the accessibility of tourist attractions and other facilities.
Novel method for determining when a field‐collected donor unit is sufficiently full
Authors: Yazer Mark H. , Werneiwski Kendall , Thompson Patrick , Titlestad Kjell , Watkins Thomas , Smith Stephen , Bengtsson Jesper , Brunetta Denise M. , Carlos Luciana , Jenkins Donald , Salcido Julian , Ngamsuntikul Samantha G. , Taye Habetamu , Kinfu Abiy , Tadesse Demewoz , Jackson Bryon P. , Kutner José , Yokoyama Ana Paula , Hess John R. , Tuott Erin , Ilmakunnas Minna , de Regt Ann K. , Wiebke Handke , Seltsam Axel , Braverman Maxwell , Compton Frances , Sutor Laurie , Meledeo Michael A. , Messenger Jacquelyn M. , DePasquale Marc 
Published: January 2024

AbstractBackgroundWhole blood (WB) collections can occur downrange for immediate administration. An important aspect of these collections is determining when the unit is sufficiently full. This project tested a novel method for determining when a field collection is complete.MethodsThe amount of empty space at the top of WB units, destined to become LTOWB or separated into components, that were collected at blood centers or hospitals was measured by holding a WB unit off the ground and placing the top of a piece of string where the donor tubing entered the bag. The string was marked where it intersected the top of the column of blood in the bag and measured from the top. The WB units were also weighed.ResultsA total of 15 different bags, two of which were measured in two different filling volumes, from 15 hospitals or blood centers were measured and weighed. The most commonly used blood bag, Terumo Imuflex SP, had a median string length of 9 mm (range: 2–24 mm) and weighed a median of 565.1 g (range: 524.8–636.7 g).ConclusionPieces of string can be precut to the appropriate length depending on the type of bag before a mission where field WB collections might be required and a mark placed on the bag before the collection commences to indicate when the unit is full.
Stepwise astronomical tuning of obliquity-driven evaporite cycles in an Eocene salt lake (Jianghan Basin, Hubei Province, China): Implications for middle Eocene East Asian monsoon-like climate evolution
Authors: Kong Xiangxin , Jiang Zaixing , Wu Shiqiang , Ge Taoyuan 
Published: January 2024

Abstract
The rhythmic evaporation cycle is an ideal recorder of astronomical cycle signals, but studies on cyclostratigraphy have yet to be directly conducted on halite-rich strata. The Qianjiang Depression of the Jianghan Basin is a representative Eocene East Asian halite-rich basin, and the salt rhythmites that developed therein are important recorders of climate evolution in East Asia. This study selected five wells for basin-scale cyclostratigraphy analysis, taking the Lower Qian 4 member of the Qianjiang Formation as the research object. This study found that the basinal salt lake facies were dominated by obliquity cycles, whereas the shallow-water deposits mainly recorded short eccentricity cycles. The study also found that s3–s6 obliquity cycles could be detected throughout the salt lake sedimentary record. Therefore, a stepwise astronomical tuning scheme was adopted. First, the target intervals in different sedimentary areas were preliminarily tuned to s3–s6 obliquity cycles, and stratigraphic correlation was performed. Then, the tuned data were further adjusted using obliquity cycles to reveal the impact of obliquity on the development of salt rhythmites and establish a floating astronomical time scale (ATS). Sedimentary noise models and pollen analysis further demonstrated that obliquity amplitude modulation cycles drove periodic changes in hydrology and climate. Based on the spatiotemporal distribution of salt rhythmite–rich strata in Paleogene East Asia, this study proposes that the development of rhythmic evaporites can reveal the existence of a monsoon-like climate. Astronomical influence was an important driving force for developing the middle Eocene East Asian monsoon.
Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature
Authors: Thomas Claire E. , Georgeson Peter , Qu Conghui , Steinfelder Robert S. , Buchanan Daniel D. , Song Mingyang , Harrison Tabitha A. , Um Caroline Y. , Hullar Meredith A. , Jenkins Mark A. , Van Guelpen Bethany , Lynch Brigid M. , Melaku Yohannes Adama , Huyghe Jeroen R. , Aglago Elom K. , Berndt Sonja I. , Boardman Lisa A. , Campbell Peter T. , Cao Yin , Chan Andrew T. , Drew David A. , Figueiredo Jane C. , French Amy J. , Giannakis Marios , Goode Ellen L. , Gruber Stephen B. , Gsur Andrea , Gunter Marc J. , Hoffmeister Michael , Hsu Li , Huang Wen-Yi , Moreno Victor , Murphy Neil , Newcomb Polly A. , Newton Christina C. , Nowak Jonathan A. , Obón-Santacana Mireia , Ogino Shuji , Sun Wei , Toland Amanda E. , Trinh Quang M. , Ugai Tomotaka , Zaidi Syed H. , Peters Ulrike , Phipps Amanda I. 
Published: January 2024

Abstract

Background:
The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors’ association with colorectal cancer risk and survival differs by SBS88.

Methods:
Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer–specific survival using Cox proportional hazards regression (N = 3,465 cases).

Results:
392 (9%) tumors were SBS88 positive. Among all cases, the highest quartile of fruit intake was associated with lower risk of SBS88-positive colorectal cancer than SBS88-negative colorectal cancer [odds ratio (OR) = 0.53, 95% confidence interval (CI) 0.37-0.76; OR = 0.75, 95% CI 0.66–0.85, respectively, Pheterogeneity = 0.047]. Among cohort studies, associations of body mass index (BMI), alcohol, and fruit intake with colorectal cancer risk differed by SBS88. BMI ≥30 kg/m2 was associated with worse colorectal cancer–specific survival among those SBS88-positive [hazard ratio (HR) = 3.40, 95% CI 1.47–7.84], but not among those SBS88-negative (HR = 0.97, 95% CI 0.78–1.21, Pheterogeneity = 0.066).

Conclusions:
Most epidemiologic factors did not differ by SBS88 for colorectal cancer risk or survival. Higher BMI may be associated with worse colorectal cancer–specific survival among those SBS88-positive; however, validation is needed in samples with whole-genome or whole-exome sequencing available.

Impact:
This study highlights the importance of identification of tumor phenotypes related to colorectal cancer and understanding potential heterogeneity for risk and survival.
Trends and Disparities in Curative-Intent Treatment for Early-Stage Non–Small Cell Lung Cancer: A Population-Based Analysis of Surgery and SBRT
Authors: Liu Qinran , Medina Heidy N. , Rodriguez Estelamari , Jacobs Kamaria T. , Brown Clyde , Koru-Sengul Tulay , Lopes Gilberto , Pinheiro Paulo S. 
Published: January 2024

Abstract

Background:
Despite the increasing adoption of stereotactic body radiotherapy (SBRT) as a recommended alternative for early-stage non–small cell lung cancer (NSCLC), population-based research on racial/ethnic disparities in curative-intent treatment accounting for SBRT remains limited. This study investigated trends and disparities in receiving curative-intent surgery and/or SBRT in a diverse, retrospective cohort.

Methods:
Early-stage NSCLC cases (2005–2017) from the Florida cancer registry were linked to individual-level statewide discharge data containing comorbidities and specific treatment information. Joinpoint regression assessed trends in treatment receipt. Multivariable logistic regression examined associations between race/ethnicity and treatment type.

Results:
Among 64,999 patients with early-stage NSCLC, 71.6% received curative-intent treatment (surgery and/or SBRT): 73.1%, 72.4%, and 60.3% among Hispanic, White, and Black patients, respectively (P &lt; 0.01). SBRT use increased steeply from 2005 to 2007 and then by 7.9% annually from 2007 to 2017 (P &lt; 0.01); curative-intent surgery remained stable from 2005 to 2014 before declining by 6.2% annually during 2014–2017 (P = 0.04). The Black-White disparity in receipt of curative-intent treatment was significant [ORadj, 0.65; 95% confidence interval (CI), 0.60–0.71]. Patients with Charlson comorbidity index (CCI)≥3 had 36% (ORadj, 0.64; 95% CI, 0.60–0.69) lower odds of receiving curative-intent surgery and no significant difference for SBRT (ORadj, 1.06; 95% CI, 0.93–1.20) compared with CCI = 0.

Conclusions:
Racial disparities in receiving curative-intent treatment for early-stage NSCLC persist despite the availability of SBRT, suggesting the full potential of curative-intent treatment for early-stage NSCLC remains unachieved.

Impact:
Addressing disparities in early-stage NSCLC requires addressing differential treatment patterns and enhancing accessibility to treatments like underutilized SBRT, particularly for high-comorbidity populations such as Black patients.
From Serendipity to Intention: Development of Brain-Penetrant PARP1-Selective Inhibitors
Authors: Lynce Filipa , Lin Nancy U. 
Published: January 2024

SummaryPrimary and secondary brain tumors cause significant mortality and constitute an important unmet need. The development of AZD9574, a brain-penetrant, PARP1-selective inhibitor with favorable pharmacologic properties and intriguing preclinical activity, has led to an ongoing clinical trial evaluating it alone and in combination with temozolomide or antibody drug conjugates.See related article by Staniszewska et al., p. 1338
Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts
Authors: Ji Jianxiong , Dragojevic Sonja , Callaghan Cameron M. , Smith Emily J. , Talele Surabhi , Zhang Wenjuan , Connors Margaret A. , Mladek Ann C. , Hu Zeng , Bakken Katrina K. , Sarkaria Paige P. , Carlson Brett L. , Burgenske Danielle M. , Decker Paul A. , Rashid Mohammad Abdur , Jang Mi-hyeon , Gupta Shiv K. , Eckel-Passow Jeanette E. , Elmquist William F. , Sarkaria Jann N. 
Published: January 2024

Abstract
Radioresistance of melanoma brain metastases limits the clinical utility of conventionally fractionated brain radiation in this disease, and strategies to improve radiation response could have significant clinical impact. The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is critical for repair of radiation-induced DNA damage, and inhibitors of this kinase can have potent effects on radiation sensitivity. In this study, the radiosensitizing effects of the DNA-PKcs inhibitor peposertib were evaluated in patient-derived xenografts of melanoma brain metastases (M12, M15, M27). In clonogenic survival assays, peposertib augmented radiation-induced killing of M12 cells at concentrations ≥100 nmol/L, and a minimum of 16 hours exposure allowed maximal sensitization. This information was integrated with pharmacokinetic modeling to define an optimal dosing regimen for peposertib of 125 mpk dosed just prior to and 7 hours after irradiation. Using this drug dosing regimen in combination with 2.5 Gy × 5 fractions of radiation, significant prolongation in median survival was observed in M12-eGFP (104%; P = 0.0015) and M15 (50%; P = 0.03), while more limited effects were seen in M27 (16%, P = 0.04). These data support the concept of developing peposertib as a radiosensitizer for brain metastases and provide a paradigm for integrating in vitro and pharmacokinetic data to define an optimal radiosensitizing regimen for potent DNA repair inhibitors.
Green Cancer Prevention and Beyond
Authors: Ross Sharon A. , Emenaker Nancy J. , Kumar Amit , Riscuta Gabriela , Biswas Kajal , Gupta Shanker , Mohammed Altaf , Shoemaker Robert H. 
Published: January 2024

Abstract
The concept of green chemoprevention was introduced in 2012 by Drs. Jed Fahey and Thomas Kensler as whole-plant foods and/or extract-based interventions demonstrating cancer prevention activity. Refining concepts and research demonstrating proof-of-principle approaches are highlighted within this review. Early approaches included extensively investigated whole foods, including broccoli sprouts and black raspberries showing dose–responsive effects across a range of activities in both animals and humans with minimal or no apparent toxicity. A recent randomized crossover trial evaluating the detoxification of tobacco carcinogens by a broccoli seed and sprout extract in the high-risk cohort of current smokers highlights the use of a dietary supplement as a potential next-generation green chemoprevention or green cancer prevention approach. Challenges are addressed, including the selection of dose, duration and mode of delivery, choice of control group, and standardization of the plant food or extract. Identification and characterization of molecular targets and careful selection of high-risk cohorts for study are additional important considerations when designing studies. Goals for precision green cancer prevention include acquiring robust evidence from carefully controlled human studies linking plant foods, extracts, and compounds to modulation of targets for cancer risk reduction in individual cancer types.
Social Construction of Unsubsidized Healthy Latrines
Authors: Sucahya Media , Sihabudin Ahmad , Widowati Dewi 
Published: January 2024

Recent data have shown that approximately 5.86% of 275.773 million of the Indonesian population are practicing open defecation. To align with the sustainable development goals (SDGs), efforts are being made to eradicate unhealthy lifestyle behaviors, including open dedication, by 2030. This achievement requires the intervention of both government and non-governmental organizations, as shown by LAZ HARFA in the Banten Province. The organizations successfully motivated impoverished citizens to construct proper sanitation facilities without subsidies.
This study aimed to understand social construction of the impoverished community towards unsubsidized healthy latrines program implemented by LAZ HARFA in the Kertaraharja village, Pandeglang Regency, Banten. The analysis was carried out using a qualitative approach, by employing a purposive sampling technique to select informants based on their involvement in healthy latrines program. The total number of informants was 15, consisting of 8, 6, and 4 as key, main, and additional informants, respectively.
The results showed that the community firmly believed in achieving unsubsidized healthy latrines program was possible, despite their impoverished conditions. This program was recognized as a step towards adopting a clean and healthy lifestyle. The community shifted the mindset from practicing open defecation to embracing a clean and healthy lifestyle through collaborative efforts, conducting transcheck walks, village mapping, and making commitments to participate in healthy latrines program. Furthermore, social interaction was fostered among the community through the purchase of materials for constructing latrines facilities and toiletries. LAZ HARFA also employed participatory development communication model that focused on provocation and simulation to evoke feelings of shame, disgust, and nausea. The community introduced economic empowerment and environmental quality enhancement programs to accelerate the progress of healthy latrines program.
A Ficção Científica, a urgência climática e a importância de diálogo entre os saberes: entrevista com a escritora e pesquisadora Ana Rüsche
Authors: Matangrano Bruno Anselmi 
Published: January 2024

Este trabalho trata-se de uma entrevista com a escritora e pesquisadora Ana Rüsche, concedida ao pesquisador Bruno Anselmi Matangrano, sobre a ficção científica enquanto uma das categorias literárias que mais tem se ocupado de questões urgentes e presentes nos debates contemporâneos. Dando especial enfoque à representação da crise climática na literatura contemporânea e ao papel da ficção científica no diálogo e na difusão de outros saberes, Rüsche define em suas respostas, em uma abordagem transdisciplinar, conceitos como a própria “ficção científica”, a teoria “ecocrítica”, a categoria da “ficção climática” e sua relação com o conceito geológico e histórico de “antropoceno” e sua contraparte, o “capitaloceno”, ao mesmo tempo em que defende a autonomia e a importância da produção literária feita no sul global e, em particular, no Brasil, em uma perspectiva decolonial. Comenta ainda a relação entre seus estudos e sua própria ficção, demonstrando o diálogo tão pouco comentado nos meios acadêmicos, mas de suma importância, entre a escrita criativa e a pesquisa acadêmica.
Circulating Sex-Specific Markers of Plaque Instability in Women and Men With Severe Carotid Atherosclerosis
Authors: Gasbarrino Karina , Zheng Huaien , Daskalopoulou Stella S. 
Published: January 2024

BACKGROUND:
Sex-specific differences in plaque composition and instability underscore the need to explore circulating markers for better prediction of high-risk plaques. This cross-sectional study aims to (1) investigate differences in lipid, immune, and adipokine circulating profiles between men and women with stable versus unstable plaques and (2) identify circulating markers that can better classify men and women according to plaque instability.

METHODS:

Preoperative blood samples and plaque specimens were collected from consecutive men and women with carotid artery stenosis ≥50% and who underwent a carotid endarterectomy between 2009 and 2018. Adipokine, lipid, and immune profiling was conducted. Plaque stability was determined by gold-standard histological classifications. Statistical analyses, including χ
2
, ANOVA, Kruskal–Wallis, and logistic regression, assessed differences in plaque features and blood parameters between men and women with stable and unstable plaques.

RESULTS:

Of 470 recruited patients (aged 70.8±9.2 years), the final study analyses included 317 men and 143 women (aged 71.0±9.0 years). Men exhibited more unstable plaques (
P
<0.001), characterized by increased plaque hemorrhage, larger lipid core, and inflammation (
P
<0.001), along with less favorable circulating profiles. Antagonistic interactions between sex and white blood cell (WBC) counts, basophil-to-WBC ratio, and platelet counts influenced plaque instability. In men, low WBC counts, high monocyte-to-WBC ratio, low basophil-to-WBC ratio, and high LDL-C (low-density lipoprotein cholesterol) levels were associated with greater plaque instability (odds ratio, 0.827 [95% CI, 0.713–0.926], 1.158 [95% CI, 1.027–1.305], 0.495 [95% CI, 0.281–0.871], and 1.564 [95% CI, 1.001–2.443], respectively) and more unstable features (ie, inflammation, foam cells, and neovascularization). In women, a high basophil-to-WBC ratio was associated with greater plaque instability (3.142 [95% CI, 1.220–8.093]), hemorrhage, and thrombosis, while a high molecular weight-to-total adiponectin ratio was associated with decreased instability (0.014 [95% CI, 0.000–0.646]) and inflammation.

CONCLUSIONS:
Our findings demonstrated sex-specific differences, with women displaying more stable plaque phenotypes and favorable circulating profiles compared with men. This proof-of-concept study was also designed as the key first step in exploring novel sex-specific associations between circulating lipid, immune, and adipokine profiles and carotid plaque instability.