bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genomic basis of childhood T-lineage acute lymphoblastic leukemia
Authors: Mullighan Charles , Pölönen Petri , Giacomo Danika Di , Seffernick Anna , Elsayed Abdelrahman , Kimura Shunsuke , Benini Francesca , Montefiori Lindsey , Wood Brent , Xu Jason , Chen Changya , Cheng Zhongshan , Newman Haley , Myers Jason , Iacobucci Ilaria , Li Elizabeth , Sussman Jonathan , Hedges Dale , Hui Yawei , Diorio Caroline , Uppuluri Lahari , Frank David , Fan Yiping , Chang Yunchao , Meshinchi Soheil , Ries Rhonda , Shraim Rawan , Li Alexander , Bernt Kathrin , Devidas Meenakshi , Winter Stuart , Dunsmore Kimberley , Inaba Hiroto , Carroll William , Ramirez Nilsa , Philips Aaron , Kriwacki Richard , Yang Jun , Vincent Tiffaney , Loh Mignon , Rampersaud Evadnie , Raetz Elizabeth , Hunger Stephen , Tan Kai , Chang Ti-Cheng , Wu Gang , Pounds Stanley , Teachey David 
Published: October 2023

Abstract

T-lineage acute lymphoblastic leukemia (T-ALL) is a high-risk tumor that has eluded comprehensive genomic characterization, in part due to the high frequency of non-coding genomic alterations resulting in oncogene deregulation. Here we report integrated genome and transcriptome sequencing of T-ALL tumor and remission samples obtained from over 1300 uniformly treated children with T-ALL, coupled with epigenomic and single cell analysis of malignant and normal T cell precursors. Integrated analysis identified 15 subtypes with distinct genomic drivers, gene expression, developmental state and outcome. Integration with chromatin topology analyses enabled elucidation of multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific fashion, demonstrating a wide-spread involvement of the noncoding genome that has not been systematically interrogated in prior studies. We show that the immunophenotypically-described, high-risk entity of early T-cell precursor ALL is superseded by a broader category of “ETP-like” leukemia with variable immunophenotype and diverse genomic alterations of a core set of genes encoding regulators of hematopoietic stem cell development. Numerous genetic alterations and disease subtypes emerged as independent predictors of survival and treatment failure in univariable and multivariable outcome models. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease.
Drone Photogrammetry-Based Meticulous Monitoring and Management of Urban Park Green Space
Authors: Jin Rongye , Xiao Xiangdong 
Published: October 2023

Abstract

Urban park green spaces combine multiple ecological benefits and meet the entertainment and leisure needs of residents, and have attracted the attention of urban managers and various stakeholders. The benefits of urban park green space mainly come from vegetation, facilities, and the spaces they create. To better monitor and manage individual urban parks with data, suitable remote sensing methods and suitable protocols are needed for recording, evaluation, and visualization. Drones have become a potential tool for future monitoring and management of individual urban parks due to their ease of operation, cost-effectiveness, and ability to derive multiple types of data. However, previous relevant studies have not considered the particularity of urban park green space vegetation and the facilities and spaces that provide cultural value. Monitoring of vegetation mainly focused on homogeneous green spaces such as artificial forests, orchards, and street trees. Research on facilities focused on campus, cultural heritage, and road-supporting facilities. Therefore, it is necessary to explore how drones can be used to assess objects of concern (vegetation, facilities, and spaces) in urban park monitoring and management. This study draws inspiration from a variety of drone processing methods to explore a processing workflow and effective data suitable for heterogeneous urban park green spaces, making full use of all data that can be derived from drones. The results show that drones can effectively estimate tree heights through three-dimensional point clouds in heterogeneous green spaces. Missions with high-quality flight parameters have an accuracy comparable to missions targeting homogeneous green areas. At the same time, drones can effectively estimate crown width through orthophotos in heterogeneous green spaces. In addition, drones demonstrate excellent accuracy, efficiency, and good visualization when monitoring facilities and spaces. Therefore, it is feasible and effective to apply various data from drones (i.e., aerial photos, point clouds, orthophotos, and digital surface model (DSM)) in urban park green space monitoring and management. This will contribute significantly to the digital development of urban park green spaces, as well as the advancement of urban landscape ecology, landscape architecture, urban planning, and urban forestry disciplines.
Assessment of Risk Factors and Clinical Impact of Postoperative Diarrhea after Primary Colorectal Cancer Surgery
Authors: Chen Ying , Cai Zhongxiang , Liu Ying , Xie Fei , Zhong Jun , Ji Huiqin , Cheng Fan 
Published: October 2023

Abstract
Purposes
The objective of this study was to assess the clinical significance and risk factors for postoperative diarrhea following primary colorectal cancer (CRC) surgery.
Methods
This prospective cohort study included patients with CRC who underwent radical non-stomy surgery between December 2021 and April 2022 at three tertiary care hospitals in Wuhan, Hubei Province. Assessment of risk factors and clinical impact of postoperative diarrhea after CRC surgeryby univariate and multifactorial logistic regression.
Results
The incidence of postoperative diarrhea was 20.3% (41/202). Multifactorial regression analysis showed that hypertension and diabetes mellitus were strongly associated with postoperative diarrhea (P=0.035 and P=0.037). Patients who after rectal resection were more likely to have postoperative diarrhea than patients after colectomy (P=0.030). Elevated postoperative C-reactive protein (CRP) was a strong predictor of postoperative diarrhea (P＜0.001). The probability of other complications was significantly higher in patients with diarrhea than in those without diarrhea (36.6% and 14.3%, P=0.001), with a significant impact on the development of late intestinal anastomotic fistula and abdominal infection in particular (P=0.001 and P=0.003).
Conclusions
Postoperative diarrhea in CRC is independently predicted by high postoperative CRP, hypertension, diabetes mellitus, and rectal resection. Early postoperative diarrhea can cause more serious problems to emerge.
Conservative versus surgical approachs in the treatment of intracapsular condylar fractures: a retrospective study
Authors: Qi JiangHong , Deng Ying , Jiang Ling , Lu Yang , Li Wei 
Published: October 2023

Abstract
Background
Various procedures have been described for the Intracapsular condylar fractures (ICFs), but a lack of consensus on therapeutic methods. This study aimed to compare the clinical efficacy of conservative management and surgical of intracapsular condylar fractures.
Methods
This was a retrospective study. Thirty-five patients with unilateral or bilateral intracapsular condylar fractures were divided into two groups between April 2013 and April 2017. The patients in the surgery group were treated with open reduction to remove condylar fracture fragments, and those in the conservative treatment group were treated with manual reduction of the temporomandibular joint. Clinical parameters were assessed, including maximum mouth opening, occlusion, radiographic outcomes, complications, condylar reconstruction assessment using three-dimensional computed tomography, and to evaluate the function of the TMJ by observing the mouth opening function, facial shape, and occlusal relationship. The clinical features and demographic data (age, sex, fracture type, etiology, concomitant fracture, and fracture location) were also recorded.
Results
Included in the study were 35 patients (47 sides) with intracapsular condylar fractures. There were 30 male patients (85.71%) and 5 female patients (14.29%), with a mean age of 34.2 years (range: 18–59 years). The main mechanism of injury was road traffic accidents (91.43%). Furthermore, we observed that patients treated with the conservative procedure had less than treated with surgery in terms of complications (P < 0.05). No significant differences were observed between the two groups of patients regarding mouth opening and occluding (P > 0.05).
Conclusion
The results of our study showed no statistically significant difference in the clinical outcomes was found among the groups. Both surgical management and conservative management approaches for intracapsular condylar fractures are associated with significant improvements, but the conservative group had fewer complications.
Radiative Darcy-Forchheimer fluid Flow under Buongiorno model in a Moving Thin Needle with MHD and Entropy Generation
Authors: Jawad Muhammad , Fu Zhuojia 
Published: October 2023

Abstract
In this study, the Darcy-Forchheimer fluid flow in a thin needle with entropy generation is scrutinized. Nonlinear thermal radiation and MHD are considered. The consequences of Darcy flow along with Joule heating effect, Brownian motion and thermophoresis are scrutinized. Variable viscosity as well as thermal conductivity is the art of current study. To get a solution by using HAM, systems of PDEs are transmuted into non-dimensional forms by using similarity transformation. Influence of porosity parameter, Prandtl number, variable viscosity parameter, size of the needle, inertial parameter, buoyancy ratio parameter, MHD and variable thermal conductivity parameters, thermophoresis parameter and Brownian motion parameter on dimensionless cocentration, Sherwood number, velocity, temperature and Nusselt number, skin friction are explored by graphical representation. It is perceived that flow with variable thermal conductivity and viscosity is expressively dissimilar and genuine in associated with constant properties-based flow. Velocity and Temperature profile have converse influence for greater estimate of magnetic field. Larger Prandtl number declines the temperature. Amplification in values of thermal radiation parameters improved the temperature profile.
Geoelectric analysis for groundwater potential assessment and aquifer protection in a part of Shango, Northcentral Nigeria
Authors: Ejepu J.S , Jimoh M.O , Abdullahi S , Abdulfatai A I , Musa S.T , George N.J 
Published: October 2023

Abstract

Groundwater plays a crucial role in sustainable development. This study focuses on the challenges of potable water supply faced by the inhabitants of Shango area, northcentral Nigeria. The objective of this research is to identify suitable sites for new wells and boreholes by leveraging the geological and geoelectrical attributes of existing productive boreholes and hand-dug wells in the area. Vertical Electrical Sounding (VES) was employed to assess the groundwater potential, aquifer protective capacity and the corrosivity of the overburden units. The VES results revealed five subsurface geoelectric units, each exhibiting distinct characteristics contributing to the lithological variability of the research area. Hydraulic conductivity ranged from 0.465 to 0.534 m/day, while transmissivity varied from 9.589 m²/day to 26.029 m²/day across different VES points. Zones with thick layers and low resistivity values were indicative of high longitudinal conductivity. Regions with low protective capacity were found to be vulnerable to pollution and contamination from leaks, and waste sites. Conversely, regions with high protective capacity and sealing make groundwater pollution in such areas very difficult. Except for one VES point with low groundwater potential and limited withdrawal capacity for local water supply, the aquifers in the study area generally have intermediate designations. The study revealed that all VES points are in practically non-corrosive zones, making them suitable for burying underground tanks without extremely low deterioration rates. Based on geoelectrical characteristics, the study area was divided into three groundwater potential zones: low, medium, and high. These findings provide valuable insights into the groundwater potential and protective capacity of the Shango area, aiding in the sustainable management of water resources.
Integrated valorization of MSW incursion into water resources: a tool for environmental monitoring and assessment near dumpsite areas, Akwa Ibom State, Nigeria
Authors: Inyang N.E , George N.J , Ehibor I.U , Ekot A.E , Udoh I.G 
Published: October 2023

Abstract

Sites set aside for the dumping of municipal solid waste (MSW) are not used for any other purposes other than the dumping of refuse. Aside from the stench released from the dumpsites, which pollutes the air, the major issue is the dispersion of leachate from the MSW sites into the groundwater aquifers within the dumpsites and the contiguous groundwater resources. This research aims at using an integrated technique to valorize the effect of leachate from MSW sites in Uyo and Eket on the groundwater resources. Geo-electrical technology involving vertical electrical techniques and constant electrode separations were used to acquire 1D and 2D resistivity data. The interpreted resistivity results constrained by ground-truthing data were combined with hydro-physiochemical analysis to valorize the effect of MSW sites on groundwater. The VES curve types in the survey area are primarily K (57.1%), HK (21.3%), Q (14.3%) and H (7.3%), which exhibit the intercalations of various lithological suites. The inferred image maps at MSW sites showed a dispersion of leachate, which appears to follow the inverse square law between the source and the sink. The BOD-COD ratio revealed that the waste is partially biodegradable. The analyses of hydro-geochemistry of surface and groundwater in the area showed a sequence of average abundance of cations of light metals in the order:; heavy metals as:. The anionic average relative abundance takes the following order:. The use of surface water and groundwater resources for irrigation in the MSW sites has been found to be dependent on the sodium adsorption ratio and total hardness required by the crops. With the results of this study, the valorization of the ingress of leachate into groundwater resources near the MSW sites should be assessed annually to ameliorate the unfortunate environmental hazards.
Assessing the Effect of Land Use and Land Cover Changes on Land Surface Temperature in Jessore District, Bangladesh using Remote Sensing Techniques
Authors: Islam Md. Tarequl , Shahriar Md. Adil 
Published: October 2023

Abstract
Urbanization has had a significant impact on global environmental change, with more than half of the population now living in cities. Rapid population growth and changes in land use and land cover (LULC) are closely linked, leading to significant impacts on ecosystems, habitats, and regional and local climates. The drastic changes in LULC resulting from rapid urban growth have played a major role in these impacts. The rise in urban surface temperature is a result of inadequate planning and uncontrolled management of land use and land cover changes. This study utilizes multi-temporal and multi-spectral Landsat 7 ETM and Landsat 8 OLI satellite data to analyze the impact of different land use and land cover changes on surface temperature in the Jessore region of Bangladesh for the years 2000, 2010, and 2020. The analysis of land use and land cover changes indicates a significant increase in populated areas, accompanied by a noticeable decrease in vegetation, aquatic land, and agricultural land. Over the past two decades, the built-up area of the study region has almost doubled. An analysis of changes in Land Surface Temperature (LST) reveals that the built-up parts experienced the most significant increase in temperature, followed by empty space, vegetation, farmland, and water bodies. The research LULC-LST profiles also showed that the degree of heat was highest in populated regions and lowest in water bodies. The LST has risen by about\(3^\circ\)C over the past 20 years. The research shows that the amount of vegetation in the study area is declining, while the amount of non-evaporating surfaces is increasing, and the surface temperature is significantly rising. Remote sensing is an effective method for quickly studying urban growth and determining how urbanization affects LST. The findings contributed to the establishment of a policy that promoted inclusive climate resilience and made Jessore more resilient to the effects of climate change by increasing knowledge about urban LST's relationship to LULC.
Peningkatan Kemampuan Motorik Kasar Anak Melalui Permainan Tradisional Taktuk Payung Pada Anak Kelompok B TK Dharma Wanita Pacing Padas Ngawi
Authors: Hidayah Nurul , Wijayanti Arwendis , Tanto Octavian Dwi 
Published: October 2023

Tujuan penelitian ini adalah untuk mengetahui apakah permainan tradisional taktuk payung dapat meningkatkan motorik kasar anak dan untuk mengetahui bagaimana kegiatan permainan tradisional taktuk payung dapat meningkatkan motorik kasar anak di TK Dharma Wanita Pacing Tahun 2022-2023. Subjek penelitian ini yaitu 20 orang anak. Metode penelitian ini adalah Penelitian Tindakan yang mengacu pada model Penelitian Tindakan Kelas Kemmis dan Mc. Taggart yang meliputi empat tahap : perencanaan, tindakan, observasi, dan refleksi. Penelitian ini terdiri dari dua siklus, setiap siklus terdiri dari 3 kali pertemuan. Tehnik analisis data yang digunakan dalam penelitian ini adalah analisis kualitatif dan kuantitatif. Analisis data kualitatif dengan menganalisis data dari wawancara selama penelitian untuk langkah-langkah reduksi data, display data dan verifikasi data. Analisis data kuantitatif dengan statistik deskriptif yang membandingkan hasil yang diperoleh dari prasiklus, siklus I dan siklus II. Hasil penelitian ini menunjukkan adanya peningkatan kemampuan motorik kasar anak melalui permainan tradisional taktuk payung, dibuktikan dengan rata-rata pemahaman skor kemampuan motorik kasar prasiklus sebesar 92, kemudian meningkat pada siklus I sebesar 116, dan siklus II sebesar 154. Kata Kunci: kemampuan, motorik kasar, permainan tradisional taktuk payung
Correlations among AHP-based scenic beauty estimation and water quality indicators of typical urban constructed WQT wetland park landscaping
Authors: Huang Yan , Li Tianjie , Jin Yang , Wu Wenting 
Published: October 2023

Abstract

Water environments of urban constructed water quality treatment (WQT) wetland waterscapes are strongly related to water quality, whereas scenic beauty values help achieve better aquatic environments. However, correlations between several water quality indicators (WQIs) and scenic beauty indexes (SBIs) have not been thoroughly revealed in the existing studies. In this research, an analytic hierarchy process (AHP)-based on scenic beauty estimation (SBE) per site in two WQT wetlands has been developed. The weights of indicators were determined by the AHP voting, which includes three main criteria, i.e., conditions of vegetation, physical geographical conditions, and human geographical conditions. SBIs are voted and calculated from the professional group and the unprofessional group. WQIs of typical pollutants (i.e., dissolved oxygen (DO), CODCr, NH3-N, pH, and total phosphorus) were sampled in situ simultaneously. Inter-relationships among SBIs and WQIs are indicated by correlative analysis and a regression model, which highlights that DO increase, CODCr removal, and NH3-N removal can explain 68.8% of changes in the SBI. Accordingly, applications for WQT wetland eco-engineered landscaping (EEL) were suggested to be conducted on quantitative estimations in three aspects, i.e., following strategies of EEL, improving WQT techniques, and applying the attention restoration theory.
Landak Industrial Park (LIP) Development Strategy
Authors: Sagala Tanty , . Surjono , . Antariksa , Cahayaning Sari Indah , Admire Dzvimbo Munyaradzi , LeaBarrett Janine 
Published: October 2023

Landak Industrial Park (KIL; Kawasan Industri Landak) is a national strategic project for Industrial Estates in West Kalimantan and is included in the List of 14 Priority Industrial Estate Developments Outside Java Island in the 2020-2024 National Medium-Term Development Plan (RPJMN; Rencana Pembangunan Jangka Menengah Nasional). The construction of KIL is experiencing delays, and to prevent the project from stalling, the main sources of industrial growth are new investment and increased utility from the current capacity. This study’s approach is both qualitative and quantitative. The analysis technique used is SWOT analysis using Internal Strategic Factor Analysis Summary (IFAS) and External Strategic Factor Analysis Summary (EFAS), developed using spatial analysis techniques from the concept of economic aggregation, which then generates value propositions and makes them the basis of a marketing strategy that includes market segmentation (segmenting), setting market targets (targeting), and creating a unique position (positioning). The result is from the SWOT analysis. KIL is in the turnaround quadrant, a position with a strategy of maximizing opportunities because it has major internal weaknesses. The geographical reach of other economic groups or business clusters that are quite close together is a trigger for the development of KIL. Scenarios from the KIL development strategy are expected to support strategic business decisions.
Innovative Approaches to Menstruation and Fertility Tracking Using Wearable Reproductive Health Technology: Systematic Review
Authors: Lyzwinski Lynnette , Elgendi Mohamed , Menon Carlo 
Published: October 2023

Background
Emerging digital health technology has moved into the reproductive health market for female individuals. In the past, mobile health apps have been used to monitor the menstrual cycle using manual entry. New technological trends involve the use of wearable devices to track fertility by assessing physiological changes such as temperature, heart rate, and respiratory rate.

Objective
The primary aims of this study are to review the types of wearables that have been developed and evaluated for menstrual cycle tracking and to examine whether they may detect changes in the menstrual cycle in female individuals. Another aim is to review whether these devices are effective for tracking various stages in the menstrual cycle including ovulation and menstruation. Finally, the secondary aim is to assess whether the studies have validated their findings by reporting accuracy and sensitivity.

Methods
A review of PubMed or MEDLINE was undertaken to evaluate wearable devices for their effectiveness in predicting fertility and differentiating between the different stages of the menstrual cycle.

Results
Fertility cycle–tracking wearables include devices that can be worn on the wrists, on the fingers, intravaginally, and inside the ear. Wearable devices hold promise for predicting different stages of the menstrual cycle including the fertile window and may be used by female individuals as part of their reproductive health. Most devices had high accuracy for detecting fertility and were able to differentiate between the luteal phase (early and late), fertile window, and menstruation by assessing changes in heart rate, heart rate variability, temperature, and respiratory rate.

Conclusions
More research is needed to evaluate consumer perspectives on reproductive technology for monitoring fertility, and ethical issues around the privacy of digital data need to be addressed. Additionally, there is also a need for more studies to validate and confirm this research, given its scarcity, especially in relation to changes in respiratory rate as a proxy for reproductive cycle staging.