bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombocyte transfusion and rebleeding rate in patients using antiplatelet agents before aneurysmal subarachnoid hemorrhage
Authors: Sebök Martina , Zaugg Natalie , Keller Emanuela , Willms Jan , Regli Luca , Germans Menno 
Published: October 2023

OBJECTIVE
The reason for a rebleed after an initial hemorrhage in patients with aneurysmal subarachnoid hemorrhage (aSAH) is considered multifactorial. Antiplatelet use is one of the factors that has been related to early rebleed and worse outcome after aSAH. Thrombocyte transfusion overcomes the inhibitory effects of antiplatelet agents by increasing the number of functional thrombocytes, but its impact on the rebleed rate and clinical outcome remains unknown. The aim of this study was to assess the effect of thrombocyte transfusion on rebleeding and clinical outcome in patients with aSAH and prehemorrhage antiplatelet use, considering confounding factors.

METHODS
Data were prospectively collected at a single tertiary reference center for aSAH in Zurich, Switzerland. Patients with aSAH and prehemorrhage antiplatelet use were divided into "thrombocyte transfusion" and "nontransfusion" groups based on whether they did or did not receive any thrombocyte transfusion in the acute stage of aSAH after hospital admission and before the exclusion of the bleeding source. Using multivariate logistic regression analysis, the impact of thrombocyte transfusion on the rebleed rate and on clinical outcome (defined as Glasgow Outcome Scale score 1–3) was calculated.

RESULTS
One hundred fifty-seven patients were included, 87 (55.4%) of whom received thrombocyte transfusion. Eighteen (11.5%) of 157 patients had a rebleed during the hospital stay. The rebleed risk was 6.9% in the thrombocyte transfusion group and 17.1% in the nontransfusion group. After adjusting for confounders, thrombocyte transfusion showed evidence for a reduction in the rebleed rate (adjusted OR [aOR] 0.29, 95% CI 0.10–0.87). Fifty-seven patients (36.3%) achieved a poor outcome at 6 months’ follow-up. Among those 57 patients, 31 (54.4%) underwent at least one thrombocyte transfusion. Thrombocyte transfusion was not associated with poor clinical outcome at 6 months’ follow-up (aOR 0.91, 95% CI 0.39–2.15).

CONCLUSIONS
Thrombocyte transfusion in patients with aSAH and prehemorrhage antiplatelet use is independently associated with a reduction in rebleeds but shows no impact on clinical outcome at 6 months’ follow-up. Larger and randomized studies are needed to investigate the impact of thrombocyte transfusion on rebleed and outcome.
Safety of dual antiplatelet therapy in the acute phase of aneurysmal subarachnoid hemorrhage: a propensity score–matched study
Authors: Qoorchi Moheb Seraj Farid , Mirbolouk Mohammad Hossein , Vaezi Marjan , Ebrahimnia Feizollah , Gorji Reza , Najafi Sajjad , Pahlavan Shamsi Hashem , Sadeghian Shahi Ali , Sasannejad Payam , Zabihyan Samira , Mowla Ashkan , Kheradmand Daniel , Baharvahdat Humain 
Published: October 2023

OBJECTIVE
With the evolution of neuroendovascular treatments, there is a great trend to treat acutely ruptured wide-necked aneurysms with stent-assisted coiling (SAC) and flow diverters (FDs), which inevitably requires dual antiplatelet therapy (DAPT). This therapy can increase the rate of hemorrhagic complications following other neurosurgical maneuvers, such as external ventricular drain (EVD) placement or removal. In this study, the authors aimed to evaluate the safety of DAPT in patients with aneurysmal subarachnoid hemorrhage (SAH) treated with SAC or FDs and the therapy’s potential benefit in reducing cerebral ischemia and cerebral vasospasm.

METHODS
In this retrospective study, the authors reviewed the records of patients who had been admitted to their hospital with acute aneurysmal SAH and treated with SAC, FDs, and/or coiling between 2012 and 2022. Patients were classified into two groups: a DAPT group, including patients who had received DAPT for SAC or FDs, and a non-DAPT group, including patients who had not received any antiplatelet regimen and had been treated with coiling. Perioperative hemorrhagic and ischemic complications and clinical outcomes were compared between the two groups.

RESULTS
From among 938 cases of acute ruptured aneurysms treated during 10 years of study, 192 patients were included in this analysis, with 96 patients in each treatment group, after propensity score matching. All basic clinical and imaging characteristics were equivalent between the two groups except for the neck size of aneurysms (p < 0.001). EVD-related hemorrhage was significantly higher in the DAPT group than in the non-DAPT group (p = 0.035). In most patients, however, the EVD-related hemorrhage was insignificant. Parent artery or stent-induced thrombosis was higher in the DAPT group than in the non-DAPT group (p = 0.003). The rate of cerebral ischemia was slightly lower in the DAPT group than in the non-DAPT group (11.5% vs 15.6%, p = 0.399). In the multivariate analysis, cerebral ischemia, rebleeding before securing the aneurysm, extracranial hemorrhage, and cerebral vasospasm were the predictive factors of a poor clinical outcome (p < 0.001, p < 0.001, p = 0.038, and p = 0.038, respectively).

CONCLUSIONS
The DAPT regimen may be safe in the setting of acute aneurysmal SAH. Although EVD-related hemorrhage is more common in the DAPT group than the non-DAPT group, it is usually insignificant without any neurological deficit.
Combined stent retriever angioplasty and continuous intra-arterial nimodipine infusion as salvage therapy for cerebral vasospasm and delayed cerebral ischemia after subarachnoid hemorrhage: illustrative case
Authors: Knoll Andreas , Durner Gregor , Braun Michael , Schmitz Bernd , Wirtz Christian Rainer , König Ralph , Pala Andrej 
Published: October 2023

BACKGROUND
Delayed cerebral ischemia (DCI) and cerebral vasospasm (CV) are severe complications of spontaneous subarachnoid hemorrhage (SAH) contributing to an inferior outcome. Rescue therapies include intra-arterial balloon angioplasty and repetitive and finally continuous intra-arterial nimodipine infusion.

OBSERVATIONS
In the presented case, a young female patient with fulminant refractory DCI and CV, despite induced hypertension and nimodipine application, was treated with three-vessel continuous intra-arterial infusion and additional repetitive angioplasty of the basilar and middle cerebral arteries using a stent retriever, leading to a good clinical outcome. Additional stent retriever dilatation to continuous intra-arterial nimodipine application in three vessel territories may represent a further escalation step in the rescue therapy for severe CV and DCI after SAH. Montreal Cognitive Assessment and SF-36 testing showed satisfactory results 3 months after initial treatment with intra-arterial nimodipine catheters in three vessel territory circulations and additional stent retriever vasodilation of severe CV.

LESSONS
We report a unique rescue strategy involving implantation of an additional intra-arterial catheter into the vertebral artery and repetitive stent retriever dilatations of the middle cerebral and basilar arteries as an extra therapy for continuous intra-arterial nimodipine vaspospasmolytic therapy in three vessel territories, resulting in a very good clinical outcome.
Spontaneous pseudoaneurysm of the superficial temporal artery in neurofibromatosis type 1: illustrative case
Authors: Shen Fang , Li Shi-ze , Shan Yuan-yuan , Ji Xiao , Sheng Han-song 
Published: October 2023

BACKGROUND
A pseudoaneurysm of the superficial temporal artery is an uncommon clinical entity that has largely been linked with direct traumatic causes. Neurofibromatosis type 1 (NF1)-related vasculopathy is a rare cause of idiopathic arterial bleeding in the craniofacial region.

OBSERVATIONS
A 46-year-old male with clinical features of NF1 presented to the hospital with an enlarging and tender right temporal mass without a history of trauma. Computed tomography angiography suggested the development of a pseudoaneurysm, and surgery was performed to resect the mass. Histopathological examinations showed focal interruption of the epithelium layer and elastic lamina, well-demarcated thickening of the smooth muscle layers of the arterial wall, supporting the diagnosis of pseudoaneurysm.

LESSONS
NF1-associated vasculopathy is likely the predisposing factor for the development of a superficial temporal artery pseudoaneurysm.
Recurrence of arteriovenous malformation in an adult patient after complete resection: illustrative case
Authors: Mazza Elizalde Delfina C , Menendez Ricardo H , Di Fabio Maximiliano , Ruiz Douglas , Eiroa Juan Manuel , Vittar Catalina , Arias German , Sole Horacio A 
Published: October 2023

BACKGROUND
Complete resection of an arteriovenous malformation (AVM) is considered a curative treatment. In this paper the authors discuss two possibilities in the event of hemorrhage after satisfactory resection of an AVM: recurrence or remnant.

OBSERVATIONS
A 33-year-old female patient was diagnosed with an incidental right frontal AVM that was microsurgically resected and whose postoperative angiography showed no remnant. Eight years later, she presented with an episode of headache and speech arrest. Magnetic resonance imaging showed bleeding in the previous surgical site, and a new angiography revealed the presence of a vascular blush not seen previously. The patient did not show the most frequently associated factors for recurrence described in the literature, which are hemorrhage on presentation and deep venous drainage. In addition, factors related to undetected vascular remnants, such as preoperative hemorrhage and early postoperative angiography, were absent.

LESSONS
Considering the characteristics of the case, we believe that the most likely explanation is the development of a de novo vascular formation secondary to factors not yet elucidated. Preexisting views on AVM formation, the curative value of resection, and long-term follow-up in certain patients should be reevaluated.
MANAJEMEN KEAMANAN INFORMASI UNTUK TRANSFORMASI DIGITAL INSURCO BERBASIS COBIT 2019 FOCUS AREA INFORMATION SECURITY
Authors: Andyas Muhammad Anugerah , Mulyana Rahmat , Nurtrisha Widyatasya Agustika 
Published: October 2023

Previous research has shown the contribution of IT governance to digital transformation. However, further exploration is needed regarding the role of information security management in overseeing such changes through a case study of InsurCo insurance company. This is necessary in line with the latest guidance provided by PER-2/MBU/03/2023 on corporate governance and the Indonesian Financial Services Sector Master Plan 2021–2025 regarding the acceleration of digital transformation. This research method utilizes Design Science Research based on interview data. DSS05 Managed Security Service, APO13 Managed Security, and APO12 Managed Risk were selected as the priority implementation areas of the COBIT 2019 Information Security Focus Area. Capability assessments, gap analysis, recommendation development, solution design, and roadmap have been conducted on the seven related governance components. An estimated average maturity improvement of 0,8 (30,77%) was observed in these three processes. This study contributes to the knowledge base on the concept of prioritizing information security management to support organizational digital transformation, and it is particularly beneficial for InsurCo in ensuring the success of its strategic programs, as well as for the insurance industry in general.
Perancangan Konveyor Untuk Angkut Sampah pada Saluran Air Kapasitas 6 Ton/Jam
Authors: Pratama Anggi 
Published: October 2023

Sampah merupakan limbah buangan yang dihasilkan oleh manusia dan alam. Keberadaan sampah menjadi masalah bagi semua orang, karena dapat menyebabkan masalah serius pada lingkungan akibat dari penumpukan sampah yang terjadi dari waktu ke waktu. Â Penelitian ini bertujuan untuk merancangÂ alat yang dapat melakukan tugas pengangkutan dan pemindahan sampah terkhusus pada daerah saluran air. Perancangan diawali dengan pengumpulan data, pembuatan konsep rancangan, perhitungan serta analisis untuk mengetahui tegangan pada poros serta pembuatan gambar rancangan dari alat dengan software autodesk autocad 2022. Hasil rancangan ini menggunakan konveyor rantai dengan kecepatan 0,25 m/s,Â chain Tsubaki RS 40-3 Single Strand, motor AC Houle Gear Production Motor dan bantalan misumi. Konveyor pengangkat sampah ini akan ditempatkan daerah saluran air dengan lebar 1 m dan kedalam 1 meter. Rancangan konveyor memakai sistem rantai yang dipasangkan bilah-bilah pengangkut yang dapat bekerja secara kontinyu.
Lowness properties for strong reducibilities and the computational power of maximal sets
Authors: Ambos-Spies Klaus , Downey Rod , Monath Martin 
Published: October 2023

We introduce the notion of eventually uniformly weak truth table array computable (e.u.wtt-a.c.) sets. As our main result, we show that a computably enumerable (c.e.) set has this property iff it is weak truth table ([Formula: see text]-) reducible to a maximal set. Moreover, in this equivalence we may replace maximal sets by quasi-maximal sets, hyperhypersimple sets or dense simple sets and we may replace [Formula: see text]-reducibility by identity-bounded Turing reducibility (or any intermediate reducibility). Here, a set A is e.u.wtt-a.c. if there is an effective procedure which, for any given partial [Formula: see text]-functional [Formula: see text], yields a computable approximation [Formula: see text] of the domain of [Formula: see text] together with a computable indicator function [Formula: see text] and a computable order [Formula: see text] such that, once the indicator becomes positive, i.e., [Formula: see text], the number of the mind changes of the approximation g on x after stage s is bounded by [Formula: see text] where, for total [Formula: see text], the indicator eventually becomes positive on almost all arguments x of [Formula: see text]. In addition to our main result, we show several properties of the computably enumerable e.u.wtt-a.c. sets. For instance, the class of these sets is closed downwards under [Formula: see text]-reductions and closed under join. Moreover, we relate this class to – and separate it from – well known classes in the literature. On the one hand, the class of the [Formula: see text]-degrees of the c.e. e.u.wtt-a.c. sets is strictly contained in the class of the array computable c.e. [Formula: see text]-degrees. On the other hand, every bounded low set is e.u.wtt-a.c. but there are e.u.wtt-a.c. c.e. sets which are not bounded low. Here a set A is bounded low if [Formula: see text], i.e., if [Formula: see text] is ω-c.a., where [Formula: see text] is the [Formula: see text]-jump of A (Anderson, Csima and Lange ( Archive for Mathematical Logic 56(5–6) ( 2017 ) 507–521)). Finally, we prove that there is a strict hierarchy within the class of the bounded low c.e. sets A depending on the order h that bounds the number of mind changes of a computable approximation of [Formula: see text], and we show that there exists a Turing complete set A such that [Formula: see text] is h-c.a. for any computable order h with [Formula: see text].
Development and evaluation of food photograph series software for portion size estimation among urban North Indian adults
Authors: Sharma Vidisha , Chadha Ravinder 
Published: October 2023

BACKGROUND: Accurate population specific aids are needed for food portion size estimation in diet assessment. OBJECTIVE: To develop and evaluate a food photograph series software for accurate portion size estimation among urban North Indian adults. METHODS: A preliminary food consumption survey was conducted on 60 adults (25–60 years, male = female = 30) selected purposively from urban Delhi. A range of portion sizes of commonly consumed food items were standardized and photographed at 45 degree angle. An online portion size estimation tool was developed comprising data on 368 recipes and photographs for 313 food items. Real time (part A) and recalled estimation after 24 hours (part B) was done for pre-weighed food portions by participants ( n = 30, 25–60 years, male = female = 15) using the software. RESULTS: The % mean relative error in estimation of 24 pre-weighed food portions was –5±22.61% and 13.07±53.22% for parts A and B respectively. Significant correlation between actual and estimated food portions was observed ( r > 0.90, p < 0.0001). Correct picture was selected by participants in≥60% estimations while correct or adjacent picture was selected in≥89% estimations. CONCLUSIONS: The software is a useful aid for dietitians and other nutrition professionals for accurate portion size estimation among urban North Indian adults.
Evaluation of patients with low back pain due to facet joint arthrosis: The relationship between pain beliefs and pain, function, and quality of life
Authors: Okudan Begum , Çelik Derya , Koban Orkun 
Published: October 2023

OBJECTIVE: The study aimed to determine the clinical and functional status of patients with chronic low back pain (CLBP) due to facet joint arthrosis (FJA) and to examine the relationship, if any, between pain beliefs and clinical and functional status. METHODS: This descriptive, cross-sectional study involved patients who had been diagnosed with CLBP due to mild to moderate FJA. The participants were evaluated using the Numeric Pain Rating Scale (NPRS rest and activity), the Oswestry Disability Index (ODI), the Short-Form Quality of Life Index 12 version 2 (SF-12v2; PCS and MCS) and the Pain Beliefs Questionnaire (PBQ). Statistical analyses were performed using SPSS. RESULTS: This study involved 58 patients (28 females and 30 males) with a mean age of 52.12±4.64 years. The reported pain intensity was 1.93±1.52 at rest and 5.10±1.10 during activity, while the ODI was 24.59±6.61. The MCS was higher than the PCS, with mean scores of 43.52±5.86 and 38.97±5.01, respectively. The participants had higher scores for organic pain beliefs (3.81±0.51) than for psychological pain beliefs (3.35±0.69). A weak positive correlation was found between psychological pain beliefs and functional status ( r = 0.336; p = 0.010). CONCLUSIONS: Patients with CLBP due to FJA experienced mild pain at rest, moderate pain during activity, and moderate functional disability. Participants with stronger psychological pain beliefs exhibited a higher level of functional disability. Addressing pain beliefs may help to improve functional outcomes.
Can emotional distress induce acute low back pain? A systematic review
Authors: Collins Shane , McDevitt-Petrovic Orla , Henderson Ellen 
Published: October 2023

INTRODUCTION: Low back pain (LBP) is a leading cause of disability worldwide. A spectrum of psychological conditions such as anxiety, fear, stress and low mood are often reported to co-occur in individuals with persistent back pain and are cited as reasons for the continued experience of pain. However, any potential causal effect of emotional distress on new onset LBP is understudied. Therefore, the aim of this review is to examine the impact of emotional distress as a risk factor for new presentations of acute low back pain. METHODS: A systematic review was performed in accordance with the PRISMA guidelines. The Medline, Embase and APA databases were searched for primary research articles exploring emotional distress and low back pain. Prospective studies that investigated subjects initially free from back pain, who also undertook some form of psychometric testing at baseline, were included in the review. In total, 6 studies were identified with a broad geographical spread and diverse population cohorts including pregnant women, forestry workers, nursing students, adolescents, individuals with medical comorbidities and adult population studies. RESULTS: The results from all six studies found a significant relationship between an initial presence of emotional distress and subsequent onset of acute low back pain. CONCLUSION: This review encourages the acknowledgement of underlying emotional distress as a risk factor in acute low back pain, and to address it as part of the overall management plan.
Evaluasi Lingkungan Pengendalian dengan Kerangka Pengendalian Internal COSO di KPP Pratama Jakarta Pesanggrahan
Authors: Setiyaviani Sekar Puspita Ayu , Julian Lufti 
Published: October 2023

The control environment is crucial for establishing a reliable internal control system to prevent corporate fraud at the Jakarta Pesanggrahan Tax Office. It collects state revenue and accesses sensitive taxpayer information, including personal identity and financial data, making it susceptible to fraud risks. This study evaluates the control environment components of the Jakarta Pesanggrahan Tax Office using the 2013 edition of the COSO Internal Control Framework. The study used qualitative descriptive and case study methods. The population of this tax office consists of 93 employees. Primary data was collected through semi-structured interviews with 20 informants from various sections. Secondary data was collected through online sources, regulations, reports, and a literature review. The novelty in this study is that researchers used thematic analysis to produce 37 themes used as indicators in the suitability assessment of control environment components. The research results show that Jakarta Pesanggrahan Tax Office has 31 out of 37 indicators. In the "The organization demonstrates a commitment to integrity and ethical values" component, there are findings of working hours violations. In the component "The board of directors demonstrates independence from management and exercises oversight of the development and performance of internal control," there are repeated findings from the Supreme Audit Agency of the Republic of Indonesia, and the structure of the Internal Compliance Unit needs to operate independently. In the component "Management establishes, with board oversight, structures, reporting lines, and appropriate authorities and responsibilities in the pursuit of objectives," there are differences in perceptions between personnel of the Compliance Committee and inconsistencies in work positions. In the "The organization demonstrates a commitment to attract, develop, and retain competent individuals in alignment with objectives," the Jakarta Pesanggrahan Tax Office has fulfilled all indicators. Finally, in the component "The organization holds individuals accountable for their internal control responsibilities in the pursuit of objectives," the finding is the form of quality inequality resulting from employee performance ratings. Overall, the study aims to contribute to developing knowledge about the control environment in the tax office.
The Influence Of Solvatibility Ration, Company Size, TATO, ROA, DER On Return Price Of Properties Subsectors In 2019-2021
Authors: Dimyati Firda Farhany 
Published: October 2023

The purpose of this paper is to analyze the effect of solvency ratios, firm size, total turnover (TATO), return on equity (ROA) and debt-to-equity ratio (DER) on company performance/share prices in real terms. in the real estate subsector. 2019-2021 The purpose of this research is to understand the factors affecting the stock price of real estate. The research method is panel regression analysis, which uses secondary information obtained from the financial statements of listed real estate companies. The research sample consists of several companies in the real estate subsector covering a certain period. The results of the present study show that the solvency ratio, firm size, TATO, ROA and DER significantly affect the performance/share price of companies in the real estate sub-sector. Importance ratios, firm size, and ROA positively affect stock return/price, while TATO and DER affect negatively. This shows that investors tend to pay attention to these factors when evaluating the performance of real estate and determining stock prices. This study helps to understand the factors influencing the performance/share price of companies in the real estate sub-sector. The results of this study can be used as a benchmark for investors, company management and regulatory authorities in making investment decisions and policies related to real estate.