bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene Signature Associated with Nervous System in an Experimental Radiation- and Estrogen-Induced Breast Cancer Model
Authors: Calaf Gloria M. , Roy Debasish , Jara Lilian , Aguayo Francisco , Crispin Leodan A. 
Published: November 2023

Breast cancer is frequently the most diagnosed female cancer in the world. The experimental studies on cancer seldom focus on the relationship between the central nervous system and cancer. Despite extensive research into the treatment of breast cancer, chemotherapy resistance is an important issue limiting the efficacy of treatment. Novel biomarkers to predict prognosis or sensitivity to chemotherapy are urgently needed. This study examined nervous-system-related genes. The profiling of differentially expressed genes indicated that high-LET radiation, such as that emitted by radon progeny, in the presence of estrogen, induced a cascade of events indicative of tumorigenicity in human breast epithelial cells. Bioinformatic tools allowed us to analyze the genes involved in breast cancer and associated with the nervous system. The results indicated that the gene expression of the Ephrin A1 gene (EFNA1), the roundabout guidance receptor 1 (ROBO1), and the kallikrein-related peptidase 6 (KLK6) was greater in T2 and A5 than in the A3 cell line; the LIM domain kinase 2 gene (LIMK2) was greater in T2 than A3 and A5; the kallikrein-related peptidase 7 (KLK7), the neuroligin 4 X-linked gene (NLGN4X), and myelin basic protein (MBP) were greater than A3 only in T2; and the neural precursor cell expressed, developmentally down-regulated 9 gene (NEDD9) was greater in A5 than in the A3 and E cell lines. Concerning the correlation, it was found a positive correlation between ESR1 and EFNA1 in BRCA-LumA patients; with ROBO1 in BRCA-Basal patients, but this correlation was negative with the kallikrein-related peptidase 6 (KLK6) in BRCA-LumA and –LumB, as well as with LIMK2 and ROBO1 in all BRCA. It was also positive with neuroligin 4 X-linked (NLGN4X) in BRCA-Her2 and BRCA-LumB, and with MBP in BRCA-LumA and –LumB, but negative with KLK7 in all BRCA and BRCA-LumA and NEDD9 in BRCA-Her2. The differential gene expression levels between the tumor and adjacent tissue indicated that the ROBO1, KLK6, LIMK2, KLK7, NLGN4X, MBP, and NEDD9 gene expression levels were higher in normal tissues than in tumors; however, EFNA1 was higher in the tumor than the normal ones. EFNA1, LIMK2, ROBO1, KLK6, KLK7, and MBP gene expression had a negative ER status, whereas NEDD9 and NLGN4X were not significant concerning ER status. In conclusion, important markers have been analyzed concerning genes related to the nervous system, opening up a new avenue of studies in breast cancer therapy.
Compact Tunable Resonance Filters with Ultra-Broad Rejection for Silicon Photonics
Authors: Priyadarshini Pratyasha , Goswami Arnab , Velamuri Ashitosh , Das Bijoy Krishna 
Published: November 2023

<p>This paper reports a novel design of compact tuneable resonance filter with a highly extinguished and ultra-broad out-of-band rejection in CMOS compatible silicon photonics technology platform. The proposed device is designed with two identically apodized distributed grating structures for guided Fabry-Pérot resonant transmissions in a silicon on insulator rib waveguide structure. The device design parameters are optimized by theoretical simulation for a low insertion loss singly-resonant transmission peak at a desired wavelength. However, the devices were fabricated (using in-house facilities) to demonstrate multiple resonant transmission peaks along with a singly-resonant one. We observed that a device length of as low as ∼35 𝜇m exhibits a rejection band as large as ∼60 nm with an extinction of ∼40 dB with respect to the resonant wavelength peak at 𝜆𝑟∼1550 nm (FWHM ∼80 pm, IL∼2 dB). The experimental results have been shown to be closely matching to our theoretical simulation and modelling results. As expected from the theoretical prediction, the trend pertaining to the trade-off between passive insertion loss and Q-value of the resonances has been observed depending on the device parameters. The thermo-optic tuning characteristics of resonant wavelengths have been obtained by integrating microheaters in the cavity. The resonance peak has been tuned at a rate of 96 pm per mW of consumed thermal power. The thermo-optic switching response has been measured to be in the order of ~5 𝜇s. As a potential application, noise associated with an amplified pump wavelength (𝜆𝑃∼1550 nm) has been shown to be suppressed by ∼15 dB (up to the detector noise floor) which can be investigated further for large-scale integrated quantum photonic circuits. The demonstrated device can also be explored further for many other applications such as modulation, add-drop multiplexing, sensing etc. </p>
Cuidados Paliativos em Pacientes com Doenças Terminais: uma abordagem abrangente
Authors: Leite de Sousa Sandyla , Rodrigues Pereira Borges Guilherme , Pinheiro Rossini Gustavo , Marçal Roriz Caio , De Lima Braga Thauanne 
Published: November 2023

Os Cuidados Paliativos em Pacientes com Doenças Terminais representam uma abordagem abrangente e essencial no âmbito da assistência à saúde. Diante da complexidade inerente a condições terminais, essa modalidade de cuidado visa proporcionar alívio de sintomas, suporte emocional e melhoria na qualidade de vida dos pacientes, assim como de seus familiares. A abordagem abrangente dos Cuidados Paliativos transcende a mera gestão de sintomas físicos, estendendo-se à atenção às necessidades psicossociais, espirituais e éticas dos indivíduos em fase avançada de doenças. Este enfoque visa promover um cuidado integrado que respeite a dignidade e a autonomia dos pacientes, proporcionando conforto em todas as dimensões de sua experiência, mesmo diante de prognósticos desafiadores.
Ao abordar o tema dos Cuidados Paliativos em Pacientes com Doenças Terminais, este estudo busca contribuir significativamente para o entendimento profundo e abrangente dessa prática clínica. Com uma base metodológica sólida, que incluiu a análise crítica da literatura científica mais relevante e atualizada, o artigo destaca a importância de uma abordagem holística na prestação de cuidados paliativos. O objetivo é não apenas aliviar sintomas, mas também proporcionar suporte emocional e melhorar a qualidade de vida dos pacientes diante das condições terminais. Essa abordagem se baseia em evidências científicas sólidas, assegurando a robustez da revisão e fornecendo subsídios para a prática clínica.
No escopo dos Cuidados Paliativos em Pacientes com Doenças Terminais, ressalta-se a necessidade de uma seleção cuidadosa e personalizada das estratégias de intervenção, considerando a complexidade variável dessas condições. Similar à abordagem cirúrgica na Enfermidade de Crohn mencionada como exemplo, este estudo destaca a importância de escolher a estratégia mais apropriada para cada paciente. A análise profunda das abordagens disponíveis visa proporcionar insights valiosos para profissionais de saúde na tomada de decisões, visando não apenas a eficácia clínica, mas também o respeito à individualidade e dignidade dos pacientes em cuidados paliativos.
Konsep Sombong dalam Al-Qur’an
Authors: Islamiati Dian , Hamnah  , Sunantri Sri 
Published: November 2023

This research uses a type of literature research (Library Reseach) with qualitative methods. The sources in this study consist of two types, namely primary and secondary data sources. The primary data source is Tafsir Jalalain which amounts to 2 volumes, while secondary data consists of books or journals related to the theme, such as Minhâjul Qâshidin, Tazkiyatun Nafs, about the dangers of Takabur, thematic studies on Takabur in the perspective of the Qur'an and so on. In addition, data collection techniques in this study use library data sources with content analysis. As for data analysis techniques, researchers use a form of description analysis which is a form of research effort in telling problem solving based on data presentation, analysis and interpertation. The result of this study is the existence of a form of difference in terms of the definition of the meaning of arrogant contained in surah Luqman verse 18. The word consists of Marahân, mukhtal and fakhur. Marahân is an arrogant person with haughty feelings inside. Mukhtâl is an attitude of pretending to be arrogant when walking in front of others. As for fakhûr is defined as a person who is arrogant by boasting himself excessively. Based on the analysis of the interpretation of surah Luqman Verse 18 in Tafsir Jalalain, it can be concluded that one who pretends to be arrogant in walking with his face away, then the act is called Mukhtâl While one who walks on earth haughtily and feels arrogant, then the act is called fakhûr.
Validación de un instrumento para tamizaje de ca prostático en individuos mayores de 40 años
Authors: Ruiz-Pérez Alfonso Antonio , Casaubon-Vargas Mariana 
Published: November 2023

ANTECEDENTES: El cáncer de próstata, es un crecimiento descontrolado de células epiteliales de la próstata. Las acciones de detección inician a partir de los 40 años e incluyen: examen médico completo y determinación de Antígeno Prostático Específico. OBJETIVO: Elaborar y validar un instrumento para tamizaje de Cáncer de Próstata. MATERIAL Y MÉTODOS: Se realizó un estudio observacional, analítico, prospectivo, para construir, validar y aplicar un instrumento de tamizaje para Cáncer de Próstata, el cual se comparó con resultado de APE en sangre como Gold standard. RESULTADOS: El instrumento obtuvo un valor alfa de Cronbach de 0.949 en la prueba piloto y de 0.915 en la aplicación final. Se identificó una frecuencia de 0.5% en alta sospecha de riesgo de ca de próstata y un 1.4% en sospecha moderada, el 89.1% riesgo bajo y un 8.9% sin riesgo. La sensibilidad y especificidad del instrumento con respecto al APE fue de un 38% y 100% respectivamente, y con respecto al diagnóstico definitivo fueron 100% y 98%. CONCLUSIONES: El instrumento de riesgo para detección de ca de próstata es un buen candidato para ser incluido en el tamizaje clínico en poblaciones que no tienen la posibilidad de evaluar constantemente marcadores bioquímicos.
A Wolf 359 in Sheep's Clothing: Hunting for Substellar Companions in the Fifth-closest System Using Combined High-contrast Imaging and Radial Velocity Analysis
Authors: Bowens-Rubin Rachel , Akana Murphy Joseph M. , Hinz Philip M. , Limbach Mary Anne , Seifahrt Andreas , Kiman Rocio , Salama Maïssa , Mukherjee Sagnick , Brady Madison , Carter Aarynn L. , Jensen-Clem Rebecca , van Kooten Maaike A. M. , Isaacson Howard , Kosiarek Molly , Bean Jacob L. , Kasper David , Luque Rafael , Stefánsson Gudmundur , Stürmer Julian 
Published: November 2023

Abstract
Wolf 359 (CN Leo, GJ 406, Gaia DR3 3864972938605115520) is a low-mass star in the fifth-closest neighboring system (2.41 pc). Because of its relative youth and proximity, Wolf 359 offers a unique opportunity to study substellar companions around M stars using infrared high-contrast imaging and radial velocity monitoring. We present the results of Ms-band (4.67 μm) vector vortex coronagraphic imaging using Keck-NIRC2 and add 12 Keck-HIRES and 68 MAROON-X velocities to the radial velocity baseline. Our analysis incorporates these data alongside literature radial velocities from CARMENES, the High Accuracy Radial velocity Planet Searcher, and Keck-HIRES to rule out the existence of a close (a < 10 au) stellar or brown dwarf companion and the majority of large gas giant companions. Our survey does not refute or confirm the long-period radial velocity candidate, Wolf 359 b (P ∼ 2900 days), but rules out the candidate's existence as a large gas giant (>4 M
Jup) assuming an age of younger than 1 Gyr. We discuss the performance of our high-contrast imaging survey to aid future observers using Keck-NIRC2 in conjunction with the vortex coronagraph in the Ms band and conclude by exploring the direct imaging capabilities with JWST to observe Jupiter- and Neptune-mass planets around Wolf 359.
Rapid Dust Growth during Hydrodynamic Clumping due to Streaming Instability
Authors: Tominaga Ryosuke T. , Tanaka Hidekazu 
Published: November 2023

Abstract
Streaming instability is considered to be one of the dominant processes in promoting planetesimal formation by the gravitational collapse of dust clumps. The development of streaming instability is expected to form dust clumps in which the local dust density is strongly enhanced and even greater than the Roche density. The resulting clumps can collapse to form planetesimals. Recent simulations showed that such strong clumping occurs in a wider parameter space than previously expected. However, the indicated timescale for strong clumping can be on the order of tens to hundreds of Keplerian periods. In this paper, we estimate the growth time of dust grains during the pre-clumping phase. We find that the dust growth proceeds considerably before the strong clumping because even the moderate clumping due to streaming instability increases the local dust-to-gas ratio to ≳10. Depending on the sound speed, the dust collision velocity can be kept below ∼1 m s−1 once sufficiently strong dust clumping occurs. Thus, even silicate grains might have the potential to grow safely toward the size whose Stokes number is unity during the clumping. Our results demonstrate the importance of local dust coagulation during dust clumping due to streaming instability.
Cannonball or Bowling Ball: Proper Motion and Parallax for PSR J0002+6216
Authors: Bruzewski S. , Schinzel F. K. , Taylor G. B. , Demorest P. , Frail D. A. , Kerr M. , Kumar P. 
Published: November 2023

Abstract
We report the results of careful astrometric measurements of the cannonball pulsar J0002+6216 carried out over 3 yr using the High Sensitivity Array. We significantly refine the proper motion to μ = 35.3 ± 0.6 mas yr−1 and place new constraints on the distance, with the overall effect of lowering the velocity and increasing the inferred age to 47.60 ± 0.80 kyr. Although the pulsar is brought more in line with the standard natal kick distribution, this new velocity has implications for the morphology of the pulsar wind nebula that surrounds it, the density of the interstellar medium through which it travels, and the age of the supernova remnant (CTB 1) from which it originates.
Une interview inédite de John Bowlby, par le pédiatre américain Milton Senn, à Londres en 1977
Authors: Guédeney Antoine 
Published: November 2023

Interview publiée seulement en ligne, de John Bowlby par Milton Senn, ancien directeur du Child Study Center de Yale. L’interview a eu lieu à Londres le 19 octobre 1977. Ceci est la seule interview, à notre connaissance, qui ait été donnée par John Bowlby et qui soit librement disponible et dans laquelle Bowlby parle de façon très libre de ses influences, de sa trajectoire et de ses collaborations.
Une difficile proximité. Obscurité, vision et désir chez Dante et le pseudo-Denys
Authors: Piro Vincenzo 
Published: November 2023

L’essai de rapprocher le monde de Dante dans sa complexité de la spiritualité et des constructions théologiques de Denys l’Aréopagite n’a pas encore produit un résultat unanime. Malgré une proximité de thèmes, la richesse des formes du monde dantesque, sa sensibilité aux événements historiques et la figure de Béatrice semblent, au moins en partie, résister à l’intensité silencieuse de la théologie dionysienne. L’article met en évidence le caractère décisif de la question de l’obscurité dans la tentative d’établir un rapport entre la perspective dantesque et celle de Denys. À partir de la sémantisation variée du rapport entre la lumière et les ténèbres à l’œuvre chez Dante, on cherche à établir la persistance d’une inspiration dionysienne – avec une attention particulière à l’articulation entre la vision de Dieu, l’obscurité et le mouvement du désir –, telle qu’elle émerge du Chant XXXIII du Paradis .
Le sens de la route
Authors: Fabre Clément 
Published: November 2023

Comment les discours médicaux sur la différence des corps interviennent-ils dans le fonctionnement des ordres coloniaux ? La concession internationale de Shanghai, au cœur du semi-colonialisme et des réseaux médicaux occidentaux dans la Chine du xix e - xx e siècle, offre un riche observatoire pour explorer cette question. Un corpus exceptionnel sur la gestion municipale des accidents de la circulation entre 1911 et 1918 permet ici d’y traquer les conséquences pratiques des théories raciales par lesquelles certains médecins expliquent alors ces mêmes accidents.
Internalized Mental Illness Stigma is Linked to Suicidality in Rural Indian Adults with Depression or Anxiety and Chronic Physical Illness
Authors: Heylen Elsa , Srinivasan Krishnamachari , Johnson-Pradeep Ruben , Ekstrand Maria L. 
Published: November 2023

Background:
Mental illness (MI) remains stigmatized globally, including in India, where suicide and suicidality have been rising. Internalization of society’s negative stereotypes by people with MI is known as internalized MI stigma.

Aims:
The present paper examined the prevalence of internalized MI stigma in a large sample of rural Indian participants with comorbid chronic medical conditions and previously undiagnosed, mostly mild-to-moderate depression/anxiety. It further examined correlates of internalized MI stigma and its association with suicidality.

Subjects and Methods:
Face-to-face interviews were conducted at four-time points with adults with depression/anxiety and chronic physical illness in primary health centers in Ramanagaram, Karnataka. Topics included demographics, social support, depression (9-item Patient Health Questionnaire scale), anxiety (7-item General Anxiety Disorder scale), suicidality (Mini-International Neuropsychiatric Interview), and internalized MI stigma (Internalized Stigma of Mental Illness [ISMI] scale). Data analysis included linear and hierarchical logistic regression.

Results:
At baseline, 29.1% of participants showed a high level of internalized stigma, and 10.4% exhibited at least moderate suicidality. Hierarchical logistic regression showed that every 1-point increase on the ISMI scale more than tripled the odds of moderate to high suicidality (adjusted odds ratio [AOR] 3.24). Those being at least moderately depressed/anxious were 2.4 times more likely to be at least moderately suicidal than participants with no-mild depression/anxiety. Social support lowered the odds of suicidality (AOR 0.44).

Conclusions:
Internalized MI stigma and suicidality were substantial among these rural adults with mostly mild-to-moderate anxiety/depression. Higher stigma was associated with increased suicidality, independently of depression/anxiety. Therefore, efforts to reduce internalized MI stigma should be included in mental health treatment.
Meta-Analysis of Effectiveness of Psychosocial Treatment Programs in Epilepsy
Authors: Ghosh Rinki , Baruah Arunjyoti 
Published: November 2023

Background:
Epilepsy is a chronic condition with numerous social and psychological consequences. There are numerous psychological and social factors associated with epilepsy, such as anxiety, depression, and stigma. These factors are prone to have poorer self-esteem, leading to lower quality of life (QOL).

Purpose:
The purpose of the current review was to identify the evidence on the effectiveness of psychosocial treatment programs in epilepsy aimed at enhancing the overall QOL in people with epilepsy.

Methods:
Various online databases such as Medline, PubMed, Science Direct, Wiley online library, and Google Scholar were searched to obtain the literature using appropriate search terms/keywords. A total of 68 articles with full texts were reviewed, of which 12 articles (11 randomized studies and 1 nonrandomized study) met the criteria and were included in the meta-analysis with a total sample size of 1712 participants. The methodological quality of the randomized studies was assessed by using the Cochrane Risk of Bias Tool.

Results:
Various psychosocial treatment programs significantly improved the QOL, self-management, and drug adherence and reduced stigma among persons with epilepsy. However, there was no evidence for effects on epilepsy self-efficacy, depression, anxiety, knowledge, and seizure frequency among persons with epilepsy.

Conclusion:
Planned psychosocial treatment programs showed significantly important benefit on a number of outcomes but found limited evidence in reducing anxiety, depression, seizure frequency, and improving knowledge among persons with epilepsy. Thus further research is needed to target those specific outcomes. Psychosocial treatment programs must be incorporated by all health-care personnel as an integral part of epilepsy care to promote patients’ optimum well-being.
Undergraduate Training in Psychiatry: Observational Perspective of Medical Officers Working at Primary Health-care Settings
Authors: Mehra Aseem , Rana Arvind , Kumar Manoj 
Published: November 2023

Background:
Primary care physicians are not adequately trained to tackle mental health problems. The study aimed to evaluate undergraduate training in Psychiatry: An observational perspective of medical officers.

Materials and Methods:
It was a cross-sectional study conducted in North India. Participants were assessed on a self-designed questionnaire developed by the Indian psychiatric society to assess various aspects of undergraduate training. Other questionnaires measured residents’ satisfaction with the quality of training programs and perceived need for psychiatric training in undergraduate courses.

Results:
The participant’s mean age was 32.4 years; majorities were male medical officers. About one-tenth reported that there were no separate psychiatry departments and designated psychiatry consultants in their college. Approximately 50% reported: No regular supervision by any psychiatric faculty or having psychiatric disorders discussions in clinical rounds. More than half (50.9%) were not confident enough to identify common signs and symptoms of psychiatric problems. From one-third to half of the participants were unsatisfied with various aspects of the training program, like teaching skills, diagnostic interviews, clinical posting, etc. Majority (77.3%–83.7%) agreed that there is a need to improve the psychiatry training program; during the clinic rounds, psychiatric diagnosis should be discussed, and psychiatry should be a separate subject in under-graduation.

Conclusion:
Primary health-care physicians were unsatisfied with an undergraduate psychiatry training program. Hence, psychiatry should be an independent subject during the undergraduate training program, with dedicated theoretical and clinical hours for psychiatry training and a separate paper for evaluation.