bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODIFIED CYCLODEXTRIN-BASED THERMOSENSITIVE IN SITU GEL FOR VORICONAZOLE OCULAR DELIVERY AGAINST FUNGAL KERATITIS
Authors: SAMPATHI SUNITHA , MADDUKURI SRAVYA , RAMAVATH RAMDAS , DODOALA SUJATHA , KUCHANA VIJAYA 
Published: January 2024

Objective: Fungal keratitis is a severe corneal infection. The present study aims to design and formulate an inclusion complex of Voriconazole-Sulfobutyl ether-beta-cyclodextrin (V-SBECD) loaded thermosensitive in-situ gel to improve solubility, therapy efficacy, durability and reduce the dose-related side effect.
Methods: Poloxamer 407, a thermosensitive polymer along with hydroxypropyl methylcellulose (HPMC E 15), were used as gelling agents; the formulations with poloxamer (16% w/v) and HPMC E15 (1 and 1.5 % w/v) led to a consistent in-situ gel at 37 °C. The formulations were evaluated for drug content, pH, gelation temperature, viscosity, sterility test, antifungal studies, and cell lines studies.
Results: The molar ratio of the drug to SBECD (1:3), showing 42-fold increase in solubility, was chosen to prepare the inclusion complexes using the lyophilization method. The stability constant was found to be 721-m. ATIR peaks, DSC thermograms and NMR spectra indicate the inclusion behavior of Voriconazole and SBECD. In vitro and ex-vivo studies demonstrated that optimized formulation sustained the drug release for over 12 h. Cellular cytotoxicity on Human corneal epithelial cells showed that V-SBECD formulations do not cause corneal epithelial damage after 24 h. In-situ gel and marketed formulation have shown a markable reduction in the growth of the Aspergillus Niger. The optimized SBECD-loaded in-situ gel formulation (F10) did not vary significantly in pH, drug content, viscosity, and % cumulative drug release, signifying stable formulations when tested at 4, 25, and 40 °C.
Conclusion: The research findings envisaged V-SBECD in-situ gel formulation as a concrete strategy to treat severe fungal keratitis.
El mandatum pecuniae credendae como garantía personal: consideraciones para su redención
Authors: Ordelin Font Jorge Luis 
Published: January 2024

La volatilidad del desarrollo económico impone un replanteamiento de los medios tradicionales que aseguren la efectividad del crédito. El ordenamiento jurídico debe buscar garantías no sólo eficaces, sino también simples y que se puedan adaptar a las condiciones particulares de cada deudor, que permitan su adaptación a las necesidades cambiantes del contexto. Dentro de estas figuras encontramos el mandato de crédito. Empero los fundamentos legales de la figura no son suficientes para el propósito práctico de este artículo, redimir una añeja, pero válida figura. Ello sólo es posible si somos capaces a la luz de los fundamentos actuales del mandato y la fianza, sustentar la viabilidad e importancia del mandato de crédito como garantía crediticia.
La capacidad de testar. Los menores de edad y su evolución
Authors: Alvarado Guerrero Antonio 
Published: January 2024

Este artículo describe el momento en que nace el derecho que los menores de edad tienen para testar. El primer esbozo de este derecho se ubica en la antigua Roma. Varios siglos después, con la importante compilación que hace el Código Napoleónico sobre distintas normas civiles y de derecho familiar, podremos observar la inamovilidad de este derecho hasta nuestros días. Posteriormente identifica las tendencias de las normas actuales y, por lo tanto, la necesidad de que el derecho a testar de los menores se transforme porque ya existen normas vigentes que avalan dicha evolución.
Exploring Movement in Creative Dance: Introducing ‘Dancemblage’ in Physical Education Teacher Education
Authors: Engdahl Christopher , Ceder Simon 
Published: January 2024

Materialities play a crucial role in both the educational practice of physical education (PE), and in physical education teacher education (PETE). This article explores how, often unnoticed, materialities, human as well as non-human, play part in movement exploration in creative dance in PETE. The methodological point of departure is a pedagogical unit in creative dance enacted as part of an optional dance course in a Swedish PETE program where movement exploration was studied. In the unit, students and a teacher collaboratively explored movement and movement assignments, including the use of materialities. In order to understand how materialities ‘co-act’ in movement exploration during class, this article provides a post-anthropocentric and Deleuzian approach. The concept dancemblage is introduced both as a way to analyse materiality and as something to work with in pedagogical practice. Moreover, the article suggests that by recognising dancemblages in creative dance teaching, teachers can be given a tool to further learn about learners’ explorations and to become open to divergent understandings about what it means to participate in creative dance.
Determinants of Toeplitz–Hessenberg Matrices with Generalized Leonardo Number Entries
Authors: Goy Taras , Shattuck Mark 
Published: January 2024

Abstract
Let un
= un
(k) denote the generalized Leonardo number defined recursively by un
= un−

1 + un−

2 + k for n ≥ 2, where u
0 = u
1 = 1. Terms of the sequence un
(1) are referred to simply as Leonardo numbers. In this paper, we find expressions for the determinants of several Toeplitz–Hessenberg matrices having generalized Leonardo number entries. These results are obtained as special cases of more general formulas for the generating function of the corresponding sequence of determinants. Special attention is paid to the cases 1 ≤ k ≤ 7, where several connections are made to entries in the On-Line Encyclopedia of Integer Sequences. By Trudi’s formula, one obtains equivalent multi-sum identities involving sums of products of generalized Leonardo numbers. Finally, in the case k = 1, we also provide combinatorial proofs of the determinant formulas, where we make extensive use of sign-changing involutions on the related structures.
Estimation of the Needed Regolith for Covering Lunar Habitat by Protective Layer
Authors: Konečný Petr , Katzer Jacek , Kobaka Janusz , Seweryn Karol 
Published: January 2024

Abstract
The article deals with estimation of the amount of regolith to be mined with respect to the preparation of lunar habitat. Estimation of the size of the pit is related to the overlay of regolith for habitat made of a composite concrete-like structure. The evaluation is based on the number of inhabitants, necessary floor area, and the considered structure that is made of three segments. The first segment is a linear vault with a half cylinder cross section ending with a half sphere on both sides of the vault. Elementary formulas for the computation of volume of cylinder and sphere are applied.
Derivations of the stress-strain relations for viscoanelastic media and the heat equation in irreversible thermodynamic with internal variables
Authors: Ciancio Vincenzo 
Published: January 2024

Abstract
By using a procedure of classical irreversible thermodynamics with internal variable (CIT-IV), some possible interactions among heat conduction and viscous-anelastic flows for rheological media are studied. In particular, we introduce as internal variables a second rank tensor

ε

α
β

(
1
)

\varepsilon _{\alpha \beta }^{(1)}

that is contribution to inelastic strain and a vector ξα
that influences the thermal transport phenomena and we derive the phenomenological equations for these variables in the anisotropic and isotropic cases. The stress-strain equations, the general flows and the temperature equation in visco-anelastic processes are obtained and when the medium is isotropic, we obtain that the total heat flux J
(q) can be split in two parts: a first contribution J
(0), governed by Fourier law, and a second contribution J
(1), obeying Maxwell-Cattaneo-Vernotte (M-C-V) equation.
A new approach to the Benjamin-Bona-Mahony equation via ultraspherical wavelets collocation method
Authors: Mulimani Mallanagoud , Srinivasa Kumbinarasaiah 
Published: January 2024

Abstract
In this paper, we develop a precise and efficient ultraspherical wavelet method for a famous Benjamin-Bona-Mahony (BBM) mathematical model. The suggested technique uses the collocation method and ultraspherical wavelets. The proposed scheme is applied to linear and nonlinear BBM equations to inspect the efficiency and accuracy of the proposed technique. The effectiveness of this practical approach is verified. Moreover, the method based on the ultraspherical wavelets is simple, accurate, fast, flexible, and convenient. The results are analyzed using tables and graphs and compared with other methods in literature. As we know, many partial differential equations (PDEs) don’t have exact solutions, and some semi-analytical methods work based on controlling parameters, but this is a controlling parameter-free technique. Also, it is pretty simple to implement and consumes less time to execute the programs. The recommended wavelet-based numerical approach is interesting, productive, and efficient. The proposed technique's convergence analysis is also presented through the theorem.
New results for generalized Hurwitz-Lerch Zeta functions using Laplace transform
Authors: Yağcı Oğuz , Şahin Recep , Nisar Kottakkaran Sooppy 
Published: January 2024

Abstract
Fractional Kinetic equations (FKEs) including a wide variety of special functions are widely and successfully applied in describing and solving many important problems of physics and astrophysics. In this work, the solutions of the FKEs of the generalized Hurwitz-Lerch Zeta function using the Laplace transform are derived and examined.
Comparing some plant communities in a region of Türkiye via fuzzy similarity
Authors: Bingöl Mesrur Ümit , Şafak Sanem Akdeniz , Akýn Ömer 
Published: January 2024

Abstract
In this study, the results obtained from forest vegetation via the research project on plant sociology which was conducted in the Black Sea region of Türkiye is evaluated with the help of a fuzzy similarity measures approach. Via this project, the plant sociology in an area which has not been studied in the Black Sea region of Türkiye is performed to investigate the plant communities and ecological and sociological relationships with each other. The similarity relations among the plant communities and relevés (sampling areas) which they covered are investigated. The issue of fuzzy similarity of sets and elements in sets is studied. According to this point of view, the fuzzy similarity among the plant communities and among the relevés is introduced. This joint study is carried out in a fuzzy environment, considering the classical results found in the project in question to be obtained in more detail for application. It is also understood that such studies can only be best performed with an interdisciplinary working group.
Aktualisasi Konsep Hredaya Kamala Madya dalam Penciptaan Tari Kamala Madya di Desa Tanjung Benoa, Bali
Authors: Ruspawati Ida Ayu Wimba 
Published: January 2024

Penelitian ini bertujuan untuk mengungkap konsep filosofis Hredaya Kamala Madya dalam Kakawin Siwaratri Kalpa dan bagaimana konsep tersebut diintegrasikan dalam penciptaan tari berjudul Kamala Madya di Desa Tanjung Benoa, Bali. Melalui metode kualitatif dengan pendekatan analisis deskriptif, penelitian ini memanfaatkan wawancara mendalam dengan Ida Bagus Wiryanatha, seorang pakar sastra kakawin, untuk merumuskan cerita dan nilai-nilai penting dalam Kakawin Siwaratri Kalpa, termasuk konsep Hredaya Kamala Madya. Analisis juga dilakukan pada video rekaman karya tari Kamala Madya untuk mengungkap bagaimana konsep tersebut terwujud dalam gerakan, musik, kostum, dan elemen penting tari. Hasil penelitian menunjukkan bahwa konsep filosofis Hredaya Kamala Madya melambangkan abstraksi bunga teratai di hati manusia, merepresentasikan penyucian batin sebagai langkah penting menuju kedamaian hati. Penelitian ini mengungkap inspirasi yang mendasari penciptaan Tari Kamala Madya dan memperkaya nilai artistik melalui simbolisme filosofis dalam elemen artistik seperti gerak tari, musik, tata rias dan busana serta property utama tarian berupa kipas. Penelitian ini diharapkan mampu memberikan wawasan mendalam terhadap pemahaman Tari Kamala Madya khususnya dalam usaha memberdayakan masyarakat Desa Tanjung Benoa sebagai destinasi pariwisata pasca Covid-19. Kata kunci: Hredaya Kamala Madya, Kakawin Siwaratri Kalpa, Inspirasi, Penciptaan Tari, Tari Kamala Madya.
Transculturalidad crítica en los <i>Seis ensayos en busca de nuestra expresión</i> de Pedro Henríquez Ureña
Authors: Barrera Enderle Víctor 
Published: January 2024

Written over two decades, the works that made up the book Seis ensayos en busca de nuestra expresión (published in Buenos Aires in 1928) deployed critical strategies to appropriate and resignify different metropolitan theoretical approaches (philological, historiographical and linguistic) for their application. to Latin American literature. Since the publication of Ensayos críticos, in 1905, Pedro Henríquez Ureña studied the formation and development of Latin American literature, both during his stay in Mexico as in Argentina. Henríquez Ureña thus became one of the first critics to propose a theoretical instrumental adapted to the particularities of the literary fields in Latin America. In this essay I propose to describe these strategies (including them in the concept of critical transculture) in Seis ensayos en busca de nuestra expresión and its importance in the configuration of Latin American critical theory.
Effect of Biopesticide Application in Suppressing the Population of Onion Caterpillar Pests (Spodoptera exigua L) in Shallot Plants (Allium ascalonikum L)
Authors: HARAHAP SRIWINATY , HARAHAP RASMITA ADELINA 
Published: January 2024

ABSTRAK
Bawang merah merupakan salah satu komoditas sayuran unggulan yang sejak lama telah diusahakan oleh petani secara intensif Komoditas ini juga merupakan sumber pendapatan yang memberikan kontribusi cukup tinggi terhadap perkembangan ekonomi wilayah, karena memiliki nilai ekonomi yang tinggi maka budidaya bawang merah telah menyebar di hampir semua provinsi di Indonesia. Jenis hama yang sering dijumpai pada tanaman bawang merah yaitu ulat bawang (Sexigua). Bawang merah merupakan inang utama bagi larva S.exigua. Kellilangan hasil akibat serangan hama ini dapat mencapai570/o karena terjadi sejak fase pertumbuhan awal sampai dengan fase pematangan umbi, bahkan bisa mengakibatkan gagal panen terutama di musim kernarau apabila pengendalian tidak dilakukan sesegera mungkin. Salah satu cara yang dapat digunakan untuk menekan pertumbuhan yaitu ulat bawang pada bawang merah dengan menggunakan pestisida nabati. Pestisida nabati mengandung senyawa aktifyang mampu mengganggu proses perkembangan ulat bawang Metode dalam penelitian ini adalah Rancangan Acak Kelompok Non Faktorial dengan masingmasing perlakuan DO ( kontrol), Dl (100 ml masing-masing daun Nimba, Serai dan Lengkuas/ liter air), D2 (200 ml masing-masing daun Nimba, Serai dan Lengkuas Iliter air), D3 (300 ml masing-masing daun Nimba, Serai dan Lengkuas [liter air) dan D4 (400 ml masing-masing daun Nimba, Serai dan Lengkuas Iliter air). Hasil penelitian menunjukkan bahwa perlakuan Biopestisida menunjukkan pengaruh yang nyata terhadap semua perlakuan yaitu intensitas serangan, persentase serangan, bobot umbi segar dan bobot umbi kering. Perlakuan terbaik terdapat pada D4.
Kata Kunci : Bawang merah, Biopestisida, Ulat bawang (Spodoptera exigua).
IMPLEMENTASI E-LEARNING DALAM PEMBELAJARAN BAHASA INDONESIA DAN LITERASI DIGITAL
Authors: Dewi Ria Candra 
Published: January 2024

ABSTRAK: Penelitian ini bertujuan untuk mengidentifikasi Implementasi E-Learning dalam pembelajaran Bahasa Indonesia dan Literasi Digital. Metode deskriptif analisis adalah metode atau pendekatan pemecahan masalah yang melibatkan penggambaran, penerangan, klarifikasi, dan penilaian keadaan dan keadaan suatu objek masalah dari sudut pandang penulis berdasarkan temuan penelitian kepustakaan (literature review) yang memberikan dukungan. Pemanfaatan e-learning dalam literasi digital dan pembelajaran bahasa Indonesia menjadi fokus permasalahan. Hasilnya menunjukkan betapa efektifnya penggunaan e-learning dalam mengajarkan literasi digital dan bahasa Indonesia kepada siswa karena dapat menyederhanakan berbagai hal bagi mereka.
KATA KUNCI: Implementasi E- Learning, Pembelajaran Bahasa Indonesia, Literasi Digital

IMPLEMENTATION OF E-LEARNING IN INDONESIAN LANGUAGE LEARNING AND DIGITAL LITERACY

ABSTRACT: This study aims to identify the Implementation of E-Learning in Indonesian learning and Digital Literacy. The descriptive method of analysis is a problem-solving method or approach that involves describing, enlightening, clarifying, and assessing the state and state of a problem object from the author's point of view based on the findings of literature review research that provides support. The use of e-learning in digital literacy and learning Indonesian the focus of the problem. The results show how effective the use of e-learning is in teaching digital literacy and Indonesian to students because it can simplify things for them.
KEYWORDS: E-Learning Implementation, Indonesian Learning, Digital Literacy
Evaluation of Chemistry Content Knowledge and Verbal Analogical Reasoning as Potential Predictors of Teachers' Quality of Chemistry Concept Analogies
Authors: Asenjo Stephen Bryan 
Published: January 2024

This study evaluated the possible relationship of Chemistry Content Knowledge and Verbal Analogical Reasoning to Teacher's Chemistry Concept analogies among 20 Public High School Science Teachers in Cebu, Philippines using validated questionnaires. Test for Chemistry Content Knowledge showed that teacher-respondents' scores has a mean of 34.90, indicating an approaching proficiency level of knowledge in Chemistry concepts with Chemical reactions and Atomic structure as the least and mastered topics, respectively in the test. A mean of 23.10 was a result for the test in Verbal Analogical reasoning, indicating a below-average analogical reasoning skills among teacher-respondents. These then implied the need to improve teacher-respondents Chemistry Content Knowledge and Verbal Analogical Reasoning skills. Moreover, analogies by the teacher-respondents on Chemistry concepts exhibited qualities of good analogies, although some qualities such as the use of functional similarities and discussing the deviation of the target and analog concept were not observed. It was also found out that there were no significant relationship among the variables, Chemistry Content Knowledge and Verbal Analogical Reasoning as indicated by the p-value of 0.360. Moreover, relationships between Chemistry Content Knowledge to Chemistry Concept Analogies and Verbal Analogical Reasoning Analogies to Chemistry Concept Analogies were also not significant as indicated by p-values 0.097 and -0.068, respectively. Hence, Levels of Chemistry Content Knowledge and Verbal Analogical Reasoning were not predictors of the quality of analogies employed by teachers in teaching Chemistry concepts. This study aimed to provide educational experts insights into these factors' underlying relationships and improve chemistry education quality by supporting teachers' understanding of Chemistry concepts and use of analogies. Moreover, results of this study filled the gap of understanding the relationship between Chemistry Content Knowledge and Analogical Reasoning to teachers' effective use of analogies in teaching Chemistry concepts.
Consumption of Glucosinolate-Rich Nasturtium officinale and Brassica oleracea L. var. sabellica May Reduce the Risk of Cancer Occurrence in Humans
Authors: Malabed Raymond , Noel Marissa , Cabusido Marguerita Gabrielle , Chua Johnica , Janairo Lorenzo Gabriel , Sy Mikaela Beatrice , Oyong Glenn 
Published: January 2024

Vegetables containing glucosinolates, commonly referred to as crucifers, are gaining popularity due to their anticancer benefits in human. Glucosinolates are secondary metabolites that are usually found in cruciferous vegetables belonging to the family Brassicaceae. Several studies pointed out that glucosinolates could undergo hydrolysis and produce bioactive isothiocyanates, via the action of enzyme myrosinase. In this study, the total glucosinolates in watercress (Nasturtium officinale) and kale (Brassica oleracea L. var. sabellica) were quantified using high-performance liquid chromatography (HPLC). HPLC analysis revealed that watercress contains 228.93 ± 26.39 μmol/g, while kale contains 87.60 ± 80.12 μmol/g of total glucosinolates. Analysis of cyclocondensation products via HPLC directly correlates the amount of isothiocyanates present in the extracts, which were found to be 0.398 ± 0.018 and 0.378 ± 0.014 for unhydrolyzed watercress and kale, respectively. An increase in isothiocyanate content was observed for both watercress and kale after subjecting them to hydrolysis in the presence of myrosinase enzyme. Moreover, the biological activity of the extracts derived from the plants was determined using standard assay methods. Free radical DPPH assay showed that methanolic extracts of both watercress and kale exhibit antioxidant properties with the IC50 values of 13.04 ± 1.11 µg/mL and 33.14 ± 1.44 µg/mL, respectively. On the other hand, the hydrolysates showed higher scavenging activity values reported at the IC50 values of 7.69 ± 0.93 µg/mL and 20.40 ± 1.26 µg/mL, for watercress and kale, respectively. PrestoBlue™ assay also revealed the ability of the aqueous extracts to selectively target cancer cells. Watercress showed anticancer potential towards breast adenocarcinoma (MCF-7, IC50 = 17.67 ± 1.64 µg/mL). On the other hand, kale showed anticancer potential towards small lung cancer cell (H69PR, with IC50 = 19.35 ± 1.54 µg/mL) and colon cancer cell (HT-29, IC50 = 18.32 ± 2.41 µg/mL). Moreover, the extracts were found to be non-cytotoxic to normal cells (HDFn, human dermal fibroblast neonatal, IC50 >100 µg/mL), which indicates that the extracts are selective towards targeting cancer cells.
A Brief History of the Kapisanang Kimika Ng Pilipinas
Authors: Sevilla Fortunato III 
Published: January 2024

The community of chemists in the country developed from the graduates of the pharmacy program established in the University of Santo Tomas during the Spanish regime. The number of university-trained chemists increased during the American era, and eventually a formal organization of chemists, the Chemical Society of the Philippines, was established in 1937. The various aspects of the organization, from its By-Laws to its activities, during its 85 years of existence are reviewed in this paper.
Evaluating the Efficacy of Interventional Approaches for Cardiac Arrhythmias in Acute Myocardial Infarction
Authors: Wang Bin , Zhong Deshan , Shi Zhangwei , Zhang Fulong 
Published: January 2024

Objective: To assess the effectiveness of interventional treatments for cardiac arrhythmias in acute myocardial infarction (AMI). Methods: Eighty AMI patients admitted between August 2022 and August 2023 were selected and randomly assigned into groups using the random number table method. The control group (n = 40) received conventional thrombolytic treatment, while the observation group (n = 40) underwent percutaneous coronary intervention (PCI). Clinical effects were compared between the two groups. Results: Before treatment, there were no significant differences in heart rate indicators, cardiac function indicators, and physiological indicators between the two groups (P > 0.05). After treatment, the observation group showed significantly improved heart rate indicators, cardiac function indicators, and physiological indicators compared to the control group (P < 0.05). The adverse reaction rates in the observation group were lower than in the control group (P < 0.05). Conclusion: PCI treatment demonstrated significant improvements in heart rate, cardiac function, and physiological indicators among AMI patients, leading to a reduced incidence of adverse reactions such as arrhythmia. The overall effect is deemed significant.