bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overlapping systemic lupus erythematosus, seropositive erosive rheumatoid arthritis, and ANCA-associated vasculitis: A case report and literature review
Authors: Reesor Emma , Bhavsar Sankalp Virendrakumar 
Published: October 2023

ABSTRACT
The overlap of rheumatoid arthritis and systemic lupus erythematosus is well described, with a syndrome known as ‘rhupus’. ANCA-associated vasculitis, however, is uncommonly associated with other autoimmune conditions. Here, we present a case of lupus, rheumatoid arthritis, and ANCA-associated vasculitis, with significant time elapsed between presentations, resulting in an accumulation of the three diagnoses over the course of 35 years. The patient was diagnosed with lupus at age 45, presenting with inflammatory polyarthritis, thrombocytopenia, leukopenia, positive ANA, positive anti-DNA, and hypocomplementemia. She was maintained on hydroxychloroquine therapy with minimal disease activity. Approximately 20 years later, she had a flare of polyarthritis with bilateral wrist erosive arthropathy and a positive rheumatoid factor, diagnosed as rheumatoid arthritis. Anti-TNFα therapy was initiated, and she was stable for a further 10 years. At age 79, she developed ANCA-associated vasculitis AAV with pulmonary and renal manifestations, treated with rituximab induction therapy and steroids. She recovered and her MPO-ANCA titre normalised. One year later, off the anti-TNFα, she again experienced an acute kidney injury with a repeat rise in MPO-ANCA. She was re-induced and maintained on steroids and rituximab. This novel case highlights the range of possible overlap syndromes, as well as how multiple autoimmune diagnoses can evolve over decades in previously stable disease. There is growing work around polyautoimmunity with ANCA-associated vasculitis and other systemic autoimmune diseases, which has potential to identify common aetiologies and pathogenesis. Knowledge of these overlap syndromes can help to recognise and manage these conditions in a timely manner.
Effects of salt and protein intake on polyuria in V2RA-treated ADPKD patients
Authors: Geertsema Paul , Koorevaar Iris W , Ipema Karin J R , Kramers Bart J , Casteleijn Niek F , Gansevoort Ron T , Meijer Esther 
Published: October 2023

ABSTRACT

Background
The only treatment proven to be renoprotective in autosomal dominant polycystic kidney disease (ADPKD) is a vasopressin V2-receptor antagonist (V2RA). However, aquaresis-associated side effects limit tolerability. We investigated whether salt and/or protein intake influences urine volume and related endpoints in V2RA-treated ADPKD patients.

Methods
In this randomized, controlled, double-blind, crossover trial, ADPKD patients treated with maximally tolerated dose of a V2RA were included. While on a low salt and low protein diet, patients were given additional salt and protein to mimic regular intake, which was subsequently replaced by placebo in random order during four 2-week periods. Primary endpoint was change in 24-h urine volume. Secondary endpoints were change in quality of life, measured glomerular filtration rate (mGFR), blood pressure and copeptin level.

Results
Twelve patients (49 ± 8 years, 25.0% male) were included. Baseline salt and protein intake were 10.8 ± 1.3 g/24-h and 1.2 ± 0.2 g/kg/24-h, respectively. During the low salt and low protein treatment periods, intake decreased to 5.8 ± 1.6 g/24-h and 0.8 ± 0.1 g/kg/24-h, respectively. Baseline 24-h urine volume (5.9 ± 1.2 L) decreased to 5.2 ± 1.1 L (–11%, P = .004) on low salt and low protein, and to 5.4 ± 0.9 L (–8%, P = .04) on low salt. Reduction in 24-h urine volume was two times greater in patients with lower urine osmolality (–16% vs –7%). Polyuria quality of life scores improved in concordance with changes in urine volume. mGFR decreased during the low salt and low protein, while mean arterial pressure did not change during study periods. Plasma copeptin decreased significantly during low salt and low protein periods.

Conclusion
Lowering dietary salt and protein intake has a minor effect on urine volume in V2RA-treated ADPKD patients. Reduced intake of osmoles decreased copeptin concentrations and might thus increase the renoprotective effect of a V2RA in ADPKD patients.
Twenty-four-hour urine oxalate and risk of chronic kidney disease
Authors: Puurunen Marja , Kurtz Caroline , Wheeler Alistair , Mulder Kyra , Wood Kyle , Swenson Anna , Curhan Gary 
Published: October 2023

ABSTRACT

Background
To assess whether 24-h urine oxalate (UOx) excretion is a risk factor for incident chronic kidney disease (CKD).

Methods
This longitudinal observational USA-based study included 426 896 individuals aged ≥18 years with no CKD at baseline and with at least one UOx, and at least 6 months of baseline and 6 months of follow-up data. Of these, 11 239 (2.6%) had an underlying malabsorptive condition. Incident CKD, defined by relevant International Classification of Diseases codes, was identified from a multi-source data cloud containing individual-level healthcare claims and electronic medical records data. The association between categories of UOx and incident CKD was modeled using logistic regression adjusting for age, sex, race, body mass index, baseline urine calcium, urine citrate, urine volume, tobacco use, hypertension, diabetes, malabsorption and cardiovascular disease.

Results
Mean follow-up time was 38.9 months (standard deviation 21.7). Compared with individuals with UOx &lt;20 mg/24 h, the odds of developing incident CKD increased for UOx 20–29 mg/24 h [multivariable-adjusted odds ratio (MVOR) 1.14 (95% CI 1.07, 1.21)] through 80+ mg/24 h [MVOR 1.35 (1.21, 1.50)] and was statistically significant for each UOx category. A similar pattern was seen in the subgroup with a malabsorptive condition though the magnitudes of association were larger, with the odds of developing incident CKD increased for UOx 20–29 mg/24 h [MVOR 1.50 (1.03, 2.20)] through 80+ mg/24 h [MVOR 2.34 (1.50, 3.63)] as compared with UOx &lt;20 mg/24 h.

Conclusions
The risk of incident CKD increases with increasing 24-h UOx excretion. Future studies should examine whether reducing UOx diminishes the risk of developing CKD.
The serine–glycine–one-carbon metabolic network orchestrates changes in nitrogen and sulfur metabolism and shapes plant development
Authors: Rosa-Téllez Sara , Alcántara-Enguídanos Andrea , Martínez-Seidel Federico , Casatejada-Anchel Ruben , Saeheng Sompop , Bailes Clayton L , Erban Alexander , Barbosa-Medeiros David , Alepúz Paula , Matus José Tomás , Kopka Joachim , Muñoz-Bertomeu Jesús , Krueger Stephan , Roje Sanja , Fernie Alisdair R , Ros Roc 
Published: October 2023

Abstract
L-serine (Ser) and L-glycine (Gly) are critically important for the overall functioning of primary metabolism. We investigated the interaction of the phosphorylated pathway of Ser biosynthesis (PPSB) with the photorespiration-associated glycolate pathway of Ser biosynthesis (GPSB) using Arabidopsis thaliana PPSB-deficient lines, GPSB-deficient mutants, and crosses of PPSB with GPSB mutants. PPSB-deficient lines mainly showed retarded primary root growth. Mutation of the photorespiratory enzyme Ser-hydroxymethyltransferase 1 (SHMT1) in a PPSB-deficient background resumed primary root growth and induced a change in the plant metabolic pattern between roots and shoots. Grafting experiments demonstrated that metabolic changes in shoots were responsible for the changes in double mutant development. PPSB disruption led to a reduction in nitrogen (N) and sulfur (S) contents in shoots and a general transcriptional response to nutrient deficiency. Disruption of SHMT1 boosted the Gly flux out of the photorespiratory cycle, which increased the levels of the one-carbon (1C) metabolite 5,10-methylene-tetrahydrofolate and S-adenosylmethionine. Furthermore, disrupting SHMT1 reverted the transcriptional response to N and S deprivation and increased N and S contents in shoots of PPSB-deficient lines. Our work provides genetic evidence of the biological relevance of the Ser–Gly–1C metabolic network in N and S metabolism and in interorgan metabolic homeostasis.
Sustainability trade-offs in animal husbandry: Consumers’ choice when they can't have it all
Authors: Klink-Lehmann Jeanette , Tatic Milan , Weingarten Nina , Hartmann Monika 
Published: October 2023

Abstract
This paper investigates consumer choices in the presence of conflicting goals, with and without information making conflicts salient. An experimental online study was conducted with a sample of German consumers, focusing on pig farming. The results show that personal health benefits outweigh animal welfare considerations, while the latter still weigh more than environment-related sustainability attributes. Providing information can have ambiguous effects, depending on the sustainability trade-off being investigated and the type of information provided. The findings reveal that consumers are heterogeneous in their preferences for different protected goods, and these differences can be attributed to psychographic and socio-demographic factors.
The Cost of Bank Regulatory Capital
Authors: Plosser Matthew C , Santos João A C 
Published: October 2023

Abstract
Basel I introduced capital requirements for undrawn commitments, but only for revolvers with an original maturity greater than one year. We use this regulatory discontinuity to estimate the impact of capital regulation on the cost and composition of credit. Following Basel I, short-term commitment fees declined relative to long-term commitments and issuance of short-term facilities increased. Our results highlight the sensitivity of credit provision to capital regulation, particularly for banks with less capital. We are able to infer that low-capital banks are willing to forego twice as much income from fees to reduce required regulatory capital by a dollar.
A Rule of Law Analysis: Botswana’s Non-Conviction-Based Confiscation and Forfeiture Regime Under the Proceeds and Instruments of Crime Act, 2014
Authors: Lekgowe Gosego Rockfall 
Published: October 2023

Abstract
On its inception, the non-conviction-based asset confiscation and forfeiture regime attracted both praise and criticism. Using the Rule of Law as an analytic framework, this paper evaluates the non-conviction-based asset confiscation and forfeiture regime under Botswana’s Proceeds and Instruments of Crime Act, 2014. The paper finds that whilst the regime has withstood constitutional attacks, it still retains some shortcomings. For instance, there is lack of clarity on the standards of proof, procedures and inadequate protection of third-party rights. The paper recommends reforms.
Weak response of bovine hepcidin induction to iron through decreased expression of Smad4
Authors: Sadakane Hiroyuki , Matsumura Manami , Murakami Masaru , Itoyama Erina , Shimokawa Fumie , Sakota Shotaro , Yoshioka Hidetugu , Kawabata Hiroshi , Matsui Tohru , Funaba Masayuki 
Published: October 2023

AbstractHepcidin negatively regulates systemic iron levels by inhibiting iron entry into the circulation. Hepcidin production is increased in response to an increase in systemic iron via the activation of the bone morphogenetic protein (BMP) pathway. Regulation of hepcidin expression by iron status has been proposed on the basis of evidence mainly from rodents and humans. We evaluated the effect of iron administration on plasma hepcidin concentrations in calves and the expression of bovine hepcidin by the BMP pathway in a cell culture study. Hematocrit as well as levels of blood hemoglobin and plasma iron were lower than the reference level in calves aged 1–4 weeks. Although intramuscular administration of iron increased iron‐related parameters, plasma hepcidin concentrations were unaffected. Treatment with BMP6 increased hepcidin expression in human liver‐derived cells but not in bovine liver‐derived cells. A luciferase‐based reporter assay revealed that Smad4 was required for hepcidin reporter transcription induced by Smad1. The reporter activity of hepcidin was lower in the cells transfected with bovine Smad4 than in those transfected with murine Smad4. The lower expression levels of bovine Smad4 were responsible for the lower activity of the hepcidin reporter, which might be due to the instability of bovine Smad4 mRNA. In fact, the endogenous Smad4 protein levels were lower in bovine cells than in human and murine cells. Smad4 also confers TGF‐β/activin‐mediated signaling. Induction of TGF‐β‐responsive genes was also lower after treatment with TGF‐β1 in bovine hepatocytes than in human hepatoma cells. We revealed the unique regulation of bovine hepcidin expression and the characteristic TGF‐β family signaling mediated by bovine Smad4. The present study suggests that knowledge of the regulatory expression of hepcidin as well as TGF‐β family signaling obtained in murine and human cells is not always applicable to bovine cells.
Targeting sphingosine kinase 1 in p53KO thymic lymphoma
Authors: Velazquez Fabiola N. , Stith Jeffrey L. , Zhang Leiqing , Allam Amira M. , Haley John , Obeid Lina M. , Snider Ashley J. , Hannun Yusuf A. 
Published: October 2023

AbstractSphingosine kinase 1 (SK1) is a key sphingolipid enzyme that is upregulated in several types of cancer, including lymphoma which is a heterogenous group of malignancies. Treatment for lymphoma has improved significantly by the introduction of new therapies; however, subtypes with tumor protein P53 (p53) mutations or deletion have poor prognosis, making it critical to explore new therapeutic strategies in this context. SK1 has been proposed as a therapeutic target in different types of cancer; however, the effect of targeting SK1 in cancers with p53 deletion has not been evaluated yet. Previous work from our group suggests that loss of SK1 is a key event in mediating the tumor suppressive effect of p53. Employing both genetic and pharmacological approaches to inhibit SK1 function in Trp53KO mice, we show that targeting SK1 decreases tumor growth of established p53KO thymic lymphoma. Inducible deletion of Sphk1 or its pharmacological inhibition drive increased cell death in tumors which is accompanied by selective accumulation of sphingosine levels. These results demonstrate the relevance of SK1 in the growth and maintenance of lymphoma in the absence of p53 function, positioning this enzyme as a potential therapeutic target for the treatment of tumors that lack functional p53.
Study of sustainable development goals of Syrian higher education: strategy, effects and future insights
Authors: Al-Raeei Marwan 
Published: October 2023

PurposeThis research mainly aims to shed light on sustainable development in Syrian higher education during the Syrian crisis.Design/methodology/approachIn this research, the authors mainly study sustainable development in the Syrian Arab Republic through the bibliometrics data of universities and research centres in Syrian Arab Republic, where these data are related to sustainable development. Also, the authors study the strategies used in the university with the largest research output of sustainable development in the Syrian Arab Republic. The authors extract research data arranged in sustainable development goals in the Syrian Arab Republic from SciVal database.FindingsBased on the bibliometric data on sustainable development research in the Syrian Arab Republic, the authors find that universities and research centres in the Syrian Arab Republic have taken important steps towards the goals of sustainable development, especially in the year 2022. The authors also find that the University of Damascus had the largest share in research related to the goals of sustainable development, and the authors find that this is due to the strategies taken by the University of Damascus towards the goals of sustainable development, such as the policy of digital transformation, the policy of recycling and the increase of green areas in the university.Originality/valueThis study is the first of its kind to study the goals of sustainable development in Syrian higher education during the Syrian crisis period.
Job pride and work orientation among blue-collar workers in the Finnish vehicle industry
Authors: Koivunen Tuija , Pyöriä Pasi , Saari Tiina 
Published: October 2023

PurposeAlthough the number of blue-collar industrial workers has been declining, manufacturing jobs continue to have considerable importance, even in technologically advanced economies. This study gives a voice to this often-overlooked group of workers, focusing on the Finnish vehicle industry.Design/methodology/approachThe study assessed how manual workers in automotive manufacturing describe their job pride and how their accounts were related to conceptualizations of work orientation. The data included semi-structured interviews and an open-ended survey question on situations in which the respondents had felt proud of their work. The data were analysed using thematic analysis.FindingsAccording to the results, the respondents had a high level of job pride in general, but the meaning given to this attitude varied considerably, depending on the situation. The study participants' work orientation was a mixture of instrumental and intrinsic traits. However, there were also respondents who did not experience job pride or who had lost it because of the work circumstances.Originality/valueRelatively little research has assessed the importance of job pride in the context of industrial manufacturing. Recognizing job pride in its variety is crucial information for employers who aim to develop working conditions and employee retention.
Family in societal redistribution: a theoretical inquiry
Authors: Frericks Patricia 
Published: October 2023

PurposeThe family is one of the foundations of society; its significance for societal redistribution in modern societies, though, remains particularly unclear. A major reason for this is that theoretical approaches to societal redistribution have not adequately included family either in social philosophy or in welfare state theory. As a consequence, also empirical analyses of differences and developments in societal redistribution have not included family or only in as far as family is affected by other redistributive principles. This paper contributes to filling this theoretical gap.Design/methodology/approachThis paper theorises family as a redistributive principle. With reference to the major theoretical concepts of redistribution, it identifies the relevant dimensions of family in societal redistribution and develops a typology of its inclusion in societal redistribution.FindingsApproaches to redistribution are shaped by distinct concepts of equal or unequal exchange, the relevant actors they identify and by different understandings of the economy. These distinctions are central to understanding the position of family in societal redistribution. With reference to the major theoretical concepts of redistribution, this paper identifies the relevant dimensions of family in societal redistribution and develops a typology of its inclusion in societal redistribution. Further investigations might draw on this typology and detect the theoretical foundations of its conceptualisations and its similarities to and deviations from the developed types.Originality/valueThis paper provides a theoretical groundwork for theoretical and empirical investigations of societal redistribution and for better comprehending its international variation. It aims to initiate a fundamental rethinking of the usual understanding of societal redistribution that widely ignores family as a redistributive principle of its own.
Dynamic civil facility degradation prediction for rare defects under imperfect maintenance
Authors: Leu Sou-Sen , Fu Yen-Lin , Wu Pei-Lin 
Published: October 2023

PurposeThis paper aims to develop a dynamic civil facility degradation prediction model to forecast the reliability performance tendency and remaining useful life under imperfect maintenance based on the inspection records and the maintenance actions.Design/methodology/approachA real-time hidden Markov chain (HMM) model is proposed in this paper to predict the reliability performance tendency and remaining useful life under imperfect maintenance based on rare failure events. The model assumes a Poisson arrival pattern for facility failure events occurrence. HMM is further adopted to establish the transmission probabilities among stages. Finally, the simulation inference is conducted using Particle filter (PF) to estimate the most probable model parameters. Water seals at the spillway hydraulic gate in a Taiwan's reservoir are used to examine the appropriateness of the approach.FindingsThe results of defect probabilities tendency from the real-time HMM model are highly consistent with the real defect trend pattern of civil facilities. The proposed facility degradation prediction model can provide the maintenance division with early warning of potential failure to establish a proper proactive maintenance plan, even under the condition of rare defects.Originality/valueThis model is a new method of civil facility degradation prediction under imperfect maintenance, even with rare failure events. It overcomes several limitations of classical failure pattern prediction approaches and can reliably simulate the occurrence of rare defects under imperfect maintenance and the effect of inspection reliability caused by human error. Based on the degradation trend pattern prediction, effective maintenance management plans can be practically implemented to minimize the frequency of the occurrence and the consequence of civil facility failures.
Multiparameter least‐squares reverse time migration using the viscoacoustic‐wave equation
Authors: Nogueira Peterson , Porsani Milton 
Published: October 2023

AbstractIn viscoacoustic least‐squares reverse time migration methods, the reflectivity image associated with the Q factor is negligible, inverting only the velocity (v) parameter or v‐related variables such as squared slowness or bulk modulus. However, the Q factor influences the amplitude and phase of the seismic data, especially in basins containing gas reservoirs or storing . Therefore, the Q factor and its associated parameters must be considered in the context of viscoacoustic least‐squares reverse time migration. Thus, we propose a multiparameter viscoacoustic least‐squares reverse time migration procedure, which obtains the inverse of bulk modulus (κ) and the Q magnitude (τ) simultaneously. We derive and implement the multiparameter forward and adjoint pair Born operators and the gradient formulas concerning κ and τ parameters. Then, we apply these derivations in our proposed multiparameter approach, which can produce images with better balanced amplitudes and more resolution than conventional reverse time migration images.