bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of maternal voice in critically ill children undergoing suctioning with acute pain
Authors: Astuti Astuti , Nurhaeni Nani , Waluyanti Fajar Tri , Apriyanti Efa , Mutifa Juanda , Ardi Ni Bodro 
Published: November 2023

<p><strong><em>Background: </em></strong><em>Acute pain during suction in pediatric patients in the intensive care unit is unavoidable. However, it is necessary to provide non-pharmacological interventions that nurses can guide. One of the interventions that can applied in that situation is maternal voice. That intervention giving the opportunity to the children hearing the voice of their mother via voice recorder.</em><strong><em></em></strong></p><p><strong><em>Objective: </em></strong><em>This study was conducted to determine the effect of maternal voice on acute pain experienced by critically ill children during suctioning procedure.</em><strong><em></em></strong></p><p><strong><em>Methods: </em></strong><em>The research method used was quasi experiment pretest posttest without control group design. The study was conducted in May-June 2022 in the PICU in one of the hospitals in Jakarta. The research sample was selected by purposive sampling, 21 respondents assessed at the time of pretest and post-test (5 minutes before suctioning procedure, during procedure, and 5 minutes after procedure). The pain of the critically ill children was observed by FLACC (Face, Leg, Activity, Cry, Consolability) Scale.</em><strong><em></em></strong></p><p><strong><em>Results: </em></strong><em>The Saphiro Wilk test of normality data was carried out for all the data, either pretest or post-test data. Bivariate tests were analysed using Wilcoxon Signed Rank Test (for the abnormal data) and Paired T-Test (for the normal data) with the results of pain scores before and after being given maternal voice (when starting suction, p value = 0.001; after starting suction, p value = 0.001; 5 minutes after suction, p value = 0.002).</em><strong><em></em></strong></p><p><strong><em>Conclusions:</em></strong><em> PICU nurses should practice maternal voice along with suction to reduce the pain sensation received by children.</em><em></em></p>
The Journey of Data Within a Global Data Sharing Initiative: A Federated 3-Layer Data Analysis Pipeline to Scale Up Multiple Sclerosis Research
Authors: Pirmani Ashkan , De Brouwer Edward , Geys Lotte , Parciak Tina , Moreau Yves , Peeters Liesbet M 
Published: November 2023

Background
Investigating low-prevalence diseases such as multiple sclerosis is challenging because of the rather small number of individuals affected by this disease and the scattering of real-world data across numerous data sources. These obstacles impair data integration, standardization, and analysis, which negatively impact the generation of significant meaningful clinical evidence.

Objective
This study aims to present a comprehensive, research question–agnostic, multistakeholder-driven end-to-end data analysis pipeline that accommodates 3 prevalent data-sharing streams: individual data sharing, core data set sharing, and federated model sharing.

Methods
A demand-driven methodology is employed for standardization, followed by 3 streams of data acquisition, a data quality enhancement process, a data integration procedure, and a concluding analysis stage to fulfill real-world data-sharing requirements. This pipeline’s effectiveness was demonstrated through its successful implementation in the COVID-19 and multiple sclerosis global data sharing initiative.

Results
The global data sharing initiative yielded multiple scientific publications and provided extensive worldwide guidance for the community with multiple sclerosis. The pipeline facilitated gathering pertinent data from various sources, accommodating distinct sharing streams and assimilating them into a unified data set for subsequent statistical analysis or secure data examination. This pipeline contributed to the assembly of the largest data set of people with multiple sclerosis infected with COVID-19.

Conclusions
The proposed data analysis pipeline exemplifies the potential of global stakeholder collaboration and underlines the significance of evidence-based decision-making. It serves as a paradigm for how data sharing initiatives can propel advancements in health care, emphasizing its adaptability and capacity to address diverse research inquiries.
Nghiên cứu khả năng hấp phụ xanh methylene của than sinh học sản xuất từ cành thanh long (Hylocereus Sp.)
Authors: Đỗ Hải Sâm , Trần Tuyết Sương , Nguyễn Trung Hiệp , Trần Anh Khoa , Thái Phương Vũ 
Published: November 2023

Nghiên cứu trình bày quy trình xử lý cành thanh long bằng phương pháp nhiệt phân ở 550oC thu than sinh học, ứng dụng xử lý chất màu xanh methylen (MB) trong nước thải. Kết quả khảo sát cho thấy khi thời gian hấp phụ là 90 phút với nồng độ MB 40 mg/L thì hiệu suất hấp phụ có thể đạt > 95% đối với 0,3 g biochar sử dụng trong khoảng pH 8-11. Nghiên cứu xây dựng mô hình đẳng nhiệt cho thấy quá trình hấp phụ MB bằng than từ cành thanh long phù hợp với mô hình hấp phụ đơn lớp Langmuir với độ tuyến tính R2 = 0,9889 và dung lượng hấp phụ cực đại là 13,7 mg/g. Khảo sát động học cho thấy mô hình động học giả bậc 2 là phù hợp để giải thích động học quá trình hấp phụ MB lên than sinh học. Các kết quả khảo sát này chứng tỏ than sinh học từ nhiệt phân cành thanh long có thể ứng dụng trong lĩnh vực xử lý nước thải bằng phương pháp hấp phụ nhằm giải quyết vấn đề ô nhiễm từ cành thanh long và MB.
Terampil berbahasa Inggris melalui learning apps dalam mendukung sektor pariwisata dan UMKM
Authors: Sadikin Irma Savitri , Lutfiyah Lutfiyah 
Published: November 2023

Industri pariwisata di Indonesia semakin berkembang dengan pesat. Sektor pariwisata yang saat ini mengusung next normal di wilayah Indonesia semakin menggeliat. Salah satunya adalah sektor industri pariwisata yang berlokasi di Desa Kadugenep, Kecamatan Petir, Kabupaten Serang, Provinsi Banten. Potensi desa wisata dengan keindahan alam dan wilayahnya yang strategis mendorong masyarakat setempat terutama para pemuda karang taruna untuk meningkatkan keterampilan berkomunikasi dalam behasa Inggris untuk membangun dan mendorong Â sektor industri pariwisata dan UMKM semakin lebih unggul dan maju di era industri 4.0. Peserta yang mengikuti pelatihan yaitu para pemuda karang taruna desa Kadugenep yang berjumlah 20 orang. Sebagian besar telah bekerja di Kawasan wisata daerah setempat dan juga sebagai pelaku ekonomi kreatif. Pembekalan dan pelatihan melalui beberapa aplikasi pembelajaran menjadi salah satu alternatif pembelajaran mendiri yang mampu membantu para pemuda karang taruna di desa Kadugenep belajar dan berlatih menggunakan bahasa Inggris dalam bidang pariwisata seperti greeting dan introduction, travel, shopping, dining and vacation, tourism and recreation, dan topik materi pengayaan bidang pariwisata lainnya. Metode yang digunakan selama dua sesi pelatihan adalah ceramah, tanya jawab, bermain peran, dan presentasi. Hasilnya menunjukan bahwa para peserta mampu mengikuti dan memahami materi dengan cukup baik. Sebagian besar peserta mulai percaya diri dalam menggunakan bahasa Inggris dan mampu memanfaatkan aplikasi sebagai media belajar dan berlatih bahasa Inggris secara mandiri yang dapat diakses dimanapun dan kapanpun.Â
Efficacy and Safety of Mazdutide in Chinese Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial
Authors: Zhang Bo , Cheng Zhifeng , Chen Ji , Zhang Xin , Liu Dexue , Jiang Hongwei , Ma Guoqing , Wang Xiaoyun , Gan Shenglian , Sun Juan , Jin Ping , Yi Jianjun , Shi Bimin , Ma Jianhua , Ye Shandong , Wang Guixia , Ji Linong , Gu Xuejiang , Yu Ting , An Pei , Deng Huan , Li Haoyu , Li Li , Ma Qingyang , Qian Lei , Yang Wenying 
Published: November 2023

OBJECTIVE
We conducted a randomized, double-blind, placebo-controlled phase 2 trial to evaluate the efficacy and safety of mazdutide, a once-weekly glucagon-like peptide 1 and glucagon receptor dual agonist, in Chinese patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
Adults with type 2 diabetes inadequately controlled with diet and exercise alone or with stable metformin (glycated hemoglobin A1c [HbA1c] 7.0–10.5% [53–91 mmol/mol]) were randomly assigned to receive 3 mg mazdutide (n = 51), 4.5 mg mazdutide (n = 49), 6 mg mazdutide (n = 49), 1.5 mg open-label dulaglutide (n = 50), or placebo (n = 51) subcutaneously for 20 weeks. The primary outcome was change in HbA1c from baseline to week 20.

RESULTS
Mean changes in HbA1c from baseline to week 20 ranged from −1.41% to −1.67% with mazdutide (−1.35% with dulaglutide and 0.03% with placebo; all P &lt; 0.0001 vs. placebo). Mean percent changes in body weight from baseline to week 20 were dose dependent and up to −7.1% with mazdutide (−2.7% with dulaglutide and −1.4% with placebo). At week 20, participants receiving mazdutide were more likely to achieve HbA1c targets of &lt;7.0% (53 mmol/mol) and ≤6.5% (48 mmol/mol) and body weight loss from baseline of ≥5% and ≥10% compared with placebo-treated participants. The most common adverse events with mazdutide included diarrhea (36%), decreased appetite (29%), nausea (23%), vomiting (14%), and hypoglycemia (10% [8% with placebo]).

CONCLUSIONS
In Chinese patients with type 2 diabetes, mazdutide dosed up to 6 mg was generally safe and demonstrated clinically meaningful HbA1c and body weight reductions.
Arbetsintegrerat lärande genom lärandesamtal med föräldrar: En grund för pedagogers utveckling i arbete
Authors: Seitl Camilla , Eriksson Lisbeth 
Published: November 2023

I följande studie undersöks hur pedagoger beskriver sitt eget lärande och sin identitetsutveckling i ljuset av införandet av en ny typ av föräldrasamtal. Föräldrasamtalen som genomförts har skett på gruppnivå med föräldragrupper istället för de traditionella utvecklingssamtalen. I samtalen riktar pedagogerna in sig på interaktion och kollektivt lärande hos barn och vårt material för den här studien utgörs av texter som pedagogerna har skrivit för att reflektera över den nya samtalsmodellen. Syftet med studien är att förstå samtalen som en aktivitet genom vilken pedagogers lärande och identitet i arbete kan utvecklas. Texterna har analyserats genom innehållsanalys. Genom studien belystes hur förskolepedagogerna utmanas kunskapsmässigt i sammanhang med föräldrar och kollegor, varför det blir viktigt för pedagogerna att reflektera över arbetet och den egna utvecklingen. Resultatet visar hur dessa gruppsamtal bidrar till pedagogernas yrkesidentitet och lärande i arbete.
ENGLISH ABSRACT
Work integrated learning through learning conversations with Parents: A Platform for developing Preschool Teachers’ Learning at Work
The following study examines how preschool teachers describe their own learning and their own identity development concerning the introduction of a new type of parent-teacher conference. The conversation that has been conducted has taken place with groups of parents instead of the traditional individual conversations between parents and preschool teachers. In the conversations, the preschool teachers focus on interaction and collective learning among children, and our material for this study consists of texts that the preschool teachers have written to stimulate reflection concerning the new conversation model. The purpose of the study is to understand the conversations as an activity through which a preschool teacher’s learning and identity at work can be developed. Using content analysis, the study highlights how preschool teachers are challenged in terms of knowledge in the context of parents and colleagues, which is why it becomes important for preschool teachers to reflect upon their work and their own development. In addition, the results show how these group conversations contribute to the preschool teacher’s professional identity and learning at work.
Suggested Approach to Solve Nonlinear Ordinary Differential Equations
Authors: A. Hussein Noor , Obaid Firas Jawad 
Published: November 2023

In this research a suggested method has been proposed to solve the non-linear ordinary differential equations, This method is somewhat similar to the Adomain decomposition method of solving equations but it is quite different in the using steps to find the non-linear boundaries , in the suggested method does not use an unknown parameter to calculate non-linear boundaries as well as the steps used to calculate non-linear boundaries are very simple and do not need many and complex steps. we can be called this approach by Fatima style to solve nonlinear ODE.
Prognostic value of coronary microvascular dysfunction in patients with aortic stenosis and nonobstructed coronary arteries
Authors: Mohammed Ayman A. , Zhang Hengbin , Li Siqi , Liu Lu , Mareai Redhwan M. , Xu Yawei , Abdu Fuad A. , Che Wenliang 
Published: November 2023

Background
Patients with aortic valve stenosis have been postulated to have coronary microvascular dysfunction (CMD) contributing to the clinical symptoms and adverse outcomes. The coronary angiography (CAG)-derived index of microcirculatory resistance (caIMR) is proposed as a novel, less invasive and pressure-wire-free index to assess CMD. This study aimed to quantify CMD assessed by caIMR and investigate its prognostic impact in patients with aortic valve stenosis.

Methods
This study included 77 moderate or severe aortic valve stenosis patients with no obstructive coronary disease (defined as having no stenosis more than 50% in diameter) who underwent caIMR measurement. CMD was defined by caIMR at least 25. Major adverse cardiovascular events (MACE) were the clinical outcomes during the median 40 months of follow-up.

Results
The incidence of CMD was 47.7%. Seventeen MACE occurred during the follow-up duration. CMD was associated with an increased risk of MACE (log-rank P < 0.001) and an independent predictor of clinical outcomes [hazard ratio 5.467, 95% confidence interval (CI) 1.393–21.458; P = 0.015]. The receiver-operating characteristic (ROC) curve analysis demonstrated that caIMR could provide a significant predictive value for MACE in aortic valve stenosis patients (AUC 0.785, 95% CI 0.609–0.961, P < 0.001). In addition, the risk of MACE was higher in CMD patients with severe aortic valve stenosis (log-rank P < 0.001) and no aortic valve replacement (log-rank P = 0.003) than in other groups.

Conclusion
Aortic valve stenosis patients demonstrated markedly impaired caIMR. CMD assessed by caIMR increases the risk of MACE and is an independent predictor of adverse outcomes in aortic valve stenosis patients. This finding suggests that using caIMR in the clinical assessment may help identify high-risk groups and stimulate earlier intervention.
Assessing stakeholders’ opinions on sharing antimicrobial susceptibility testing data from animals is key to developing a centralized database and dashboard tool
Authors: Raineri Raissa R. , Shivley Chelsey B. , Plummer Paul J. , Kreuder Amanda J. 
Published: November 2023

Abstract

OBJECTIVE
To present, analyze, and discuss stakeholders’ opinions regarding sharing antimicrobial susceptibility testing (AST) data from animals into a centralized database and dashboard tool that would collect, aggregate, store, and analyze this type of data from veterinary diagnostic laboratories (VDLs) across the country.

SAMPLE
1 in-person focus group (9 participants), 9 virtual focus groups (49 participants), and online pre- and postmeeting surveys (76 and 35 participants, respectively).

METHODS
Focus groups and surveys were conducted to assess the opinions of veterinarians, producers, researchers, diagnosticians, and government officials.

RESULTS
A strong majority of stakeholders recognize AMR as a serious concern for both human and animal health and see several benefits in establishing a centralized AMR database; however, several concerns were raised associated with data confidentiality, security, curation, and harmonization. In the interest of alleviating those concerns, among other items, stakeholders suggested education and training of data users, providers, and the public in addition to assuring strong data confidentiality protections.

CLINICAL RELEVANCE
Stakeholder engagement is a critical component of all stages of development, implementation, and utilization of an AMR database and dashboard tool that could be used to inform antimicrobial stewardship in veterinary medicine. This assessment of stakeholders’ needs and concerns can be used to help guide future recommendations for data legal protections as well as a data confidentiality and security framework. Maintaining open communication on data usage, storage, and security as well as involvement and education of data providers, users, and the public will remain key to enabling development of an AMR database and dashboard tool for domesticated animals.
Advantages of laparoscopic-assisted ovariohysterectomy versus open ovariohysterectomy for dogs with pyometra not detected in randomized clinical trial
Authors: Brückner Michael , Dörfelt Rene 
Published: November 2023

Abstract

OBJECTIVE
To compare results for surgery time, perioperative pain, need for rescue analgesia, variables, serum C-reactive protein concentration, and postoperative complications for dogs with pyometra treated with laparoscopic-assisted ovariohysterectomy (LaOVH) versus open-surgery (OS) ovariohysterectomy.

ANIMALS
12 client-owned dogs with pyometra between June 1, 2016, and December 31, 2019.

METHODS
Dogs enrolled in this prospective single-center randomized clinical trial had pyometra confirmed by history, physical examination, ultrasonography, and blood work and were randomly assigned to treatment group LaOVH or OS. Differences in results for variables of interest were compared between groups using the Mann-Whitney U test, except the number of dogs requiring rescue analgesia was analyzed using the Fisher exact test. Values of P ≤ .05 were considered significant.

RESULTS
6 dogs were recruited in each group; results for 1 dog in the LaOVH group were excluded from further analysis due to free abdominal fluid detected during surgery. Median surgery time was significantly shorter and median total incision length was longer for the OS group (23 minutes; 106 mm), compared to the LaOVH group (37 minutes; 38 mm). No other results differed significantly between groups.

CLINICAL RELEVANCE
Although fewer patients in the LaOVH group required rescue analgesia, this was not statistically significant. Therefore, our results could not prove previously suggested advantages of LaOVH (eg, less perioperative pain or faster recovery) in dogs with pyometra. Additionally, for the LaOVH group, the median surgical time was approximately 50% longer, an assistant was needed, and specialized equipment was required.
Laparoscopic surgical treatment for sliding hiatal hernia is associated with an owner-perceived improvement in clinical outcome in dogs
Authors: Singh Ameet , Hawker William , Mitchell Krista , Appleby Ryan , Bersenas Alexa , Collier Allison 
Published: November 2023

Abstract

OBJECTIVE
To report perioperative complications and client-perceived outcome following laparoscopic surgical treatment for sliding hiatal hernia (SHH) in dogs.

ANIMALS
Client-owned dogs (n = 9).

METHODS
Medical records were reviewed and perioperative data collected including preoperative diagnostic imaging, operative details, complications, and need for conversion to open celiotomy. A single-incision, multicannulated port was inserted in the subumbilical region followed by placement of an additional 2 or 3 instrument portals. Hiatal plication, esophagopexy, and left-sided gastropexy were performed laparoscopically. Follow-up information was collected with telephone interview with the owners and/or referring veterinarian. A standardized questionnaire was completed by dog owners postoperatively.

RESULTS
Intraoperative pneumothorax occurred in 5 of 9 (55.6%) dogs and resulted in conversion to open celiotomy in 2 (22.2%) dogs. In 4 dogs, pneumothorax was suspected to be the result of progressive leakage of capnoperitoneum through the suture bite holes of the esophageal hiatal plication sutures. Hiatal plication was performed using intracorporeal simple interrupted sutures (n = 4) or a simple continuous pattern with barbed suture (4). Esophagopexy was performed using barbed suture in all dogs. Gastropexy was performed using a total laparoscopic technique (n = 4) or laparoscopic-assisted technique (3). Using a standardized questionnaire, dog owners perceived a postoperative improvement in regurgitation after eating and regurgitation after excitement/increased activity.

CLINICAL RELEVANCE
Laparoscopic treatment of SHH resulted in owner-perceived improvement in clinical signs. Intraoperative pneumothorax occurred in a high proportion of dogs but did not result in long-term sequelae.
The effects of more intensive counseling for disadvantaged unemployed youth
Authors: Eppel Rainer , Mahringer Helmut 
Published: November 2023

Abstract
Many European countries are facing the key challenge of integrating low-skilled jobless young people into the labor market. From 2018 to 2020, the Public Employment Service (PES) in Vienna tested a new model of intensified support (“case management”). The target group consisted of young unemployed persons with low formal qualifications who were drawing on social assistance. Based on the pilot project and a propensity matching approach, we show that the increase in staff significantly increased the intensity of the counseling. It led to an increase in job proposals and active labor market program participation, as well as sanctions in the form of benefit suspensions for failure to keep PES appointments. In line with the goal, more of the young people were encouraged to take part in training and further education instead of being quickly placed in an unskilled job. However, in the three-year follow-up period, the intensified counseling did not (yet) have a significant effect on the overall extent of integration into employment. Regarding post-unemployment job quality, we find no effects on wages at the start of a job.