bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction of occult metastatic disease by extension of the supraomohyoid neck dissection to include level IV
Authors: Crean St‐John , Hoffman A. , Potts John , Fardy M.J. 
Published: September 2003

AbstractBackground.Patients with clinically N0 necks will undergo elective removal of lymphatic tissue from levels I, II, and III as part of their routine surgical management. Level IV is omitted on the basis that there is negligible chance of containing significant occult disease. Evidence to support this approach is minimal, and the aim of this study was to increase the yield of metastatically involved lymph nodes by simply extending the supraomohyoid neck dissection (SOHND) to include level IV.Methods.The records of 49 patients with cancer of the oral cavity undergoing extended supraomohyoid neck dissection (ESOHND) during the period January 1996–March 1999 were reviewed. All patients were staged as having N0 disease. The follow‐up period ranged from 12 to 36 months.Results.Thirteen of 55 N0 stage necks showed occult metastasis (26.5%). Neck failure rate occurred in 4 of 49 patients (8.2%). Neck failure rate in the pN0 group was 5.4% and in the pN+ group was 16.6%. Complication rates of ESOHND were noted as 3.6%. No long‐term morbidity arose. Occult metastasis in level IV occurred in 5 of 49 cases (10%). Two cases involved other surgical levels.Conclusions.ESOHND as performed in this study removed occult level IV metastatic regional disease from an extra 10% of patients that, if the patients had undergone SOHND, would have remained undiscovered. No long‐term morbidity is associated with this procedure that the authors now recommend as a first‐line treatment in all patients with N0 necks. © 2003 Wiley Periodicals, Inc. Head Neck 25: 758–762, 2003
Kimura's disease of parotid gland presenting as solitary parotid swelling
Authors: Arshad A. R. 
Published: September 2003

AbstractBackground.Kimura's disease is a chronic inflammatory disorder of unknown etiology commonly seen among orientals and characterized histologically by lymphatic follicles, vascular proliferation, and marked eosinophilic infiltration. It has a predilection for the head and neck region. The lesion is benign but can be mistaken to be a malignant lesion.Methods.Between January 1987 and December 1999, eight cases of Kimura's disease were treated at the Department of Plastic Surgery, Hospital Kuala Lumpur. All the patients underwent surgical excision followed by initial high‐dose steroid therapy and low‐dose maintenance.Results.All the patients are men, seven belong to the Malay race and one is Chinese. The patients' ages at diagnosis are 18 to 46 years. All were initially seen with swelling in the parotid gland, ranging from 1 year to 20 years' duration. Pruritus of the overlying skin was seen in seven patients. Treatment by surgical excision and steroid therapy has led to no recurrences.Conclusion.Kimura's disease of parotid gland is rare. It is a chronic inflammatory condition also called eosinophilic hyperplastic lymphogranuloma. Treatment by surgical excision and steroid therapy has led to no recurrences. © 2003 Wiley Periodicals, Inc. Head Neck 25: 754–757, 2003
Mandibulotomy and implant insertion
Authors: Schoen Pieter J. , Raghoebar Gerry M. , Vissink Arjan , Roodenburg Jan L. N. 
Published: September 2003

AbstractBackground.A mandibulotomy can be necessary to approach a tumor in the oral cavity or oropharynx. The aim of this study was to develop and prospectively evaluate a technique enabling simultaneous performance of a mandibulotomy and insertion of endosseous implants in the same area.Methods.In five edentulous patients such a procedure was performed. The pilot drilling of the implants was done before performing the mandibulotomy. After tumor resection, reconstruction, and restoration of the continuity of the mandible, the final drilling and insertion of the implants were completed. In total, 20 implants were inserted. All patients received radiation therapy within 6 weeks after surgery. Implant‐supported overdentures were fabricated 6 months after irradiation. At regular time intervals, a standardized clinical and radiographic evaluation was performed.Results.No complications with respect to the combination of implant insertion and mandibulotomy were observed either during or after surgery. In addition, no adverse mucosal reactions were observed during the course of radiotherapy, no cases of osteoradionecrosis developed, and no implants were lost. Clinical and radiographic evaluation revealed healthy peri‐implant parameters.Conclusion.From this study it is concluded that, when following the technique described, a mandibulotomy can be combined safely with the insertion of implants in the ventral part of the edentulous mandible. © 2003 Wiley Periodicals, Inc. Head Neck 25: 748–753, 2003
Sinonasal adenocarcinoma: Immunohistochemical marking and expression of oncoproteins
Authors: Bashir Amani A. , Robinson Robert A. , Benda Jo A. , Smith Russell B. 
Published: September 2003

AbstractBackground.Relatively little is known concerning the immunohistochemical marking of sinonasal adenocarcinoma (SNA). The most clinically problematic tumors are those that seem histologically identical to colonic adenocarcinoma, a neoplasm that may metastasize to the sinonasal region. To determine whether differentiated immunohistochemical expression of keratins could differentiate primary from metastatic tumors and to understand the biology of these tumors, differentiated keratin and oncoprotein expression was investigated.Methods.Eleven patients with sinonasal adenocarcinoma were investigated for expression of cytokeratins 7 and 20 (CK7, CK20), AE 1/3, CAM 5.2, smooth muscle–specific actin, muscle‐specific actin, desmin, S‐100, carcinoembryonic antigen (CEA), p53, and HER‐2/neu.Results.All sinonasal adenocarcinomas of intestinal type were cytokeratin 7 positive. None of the tumors showed myoepithelial differentiation. Strong HER‐2/neu staining was seen in some tumors.Conclusions.Strong HER‐2/neu staining in some cases suggests this oncogene may be involved in the genesis of SNA. Immunohistochemical staining with cytokeratin 7 may be potentially useful in differentiating primary from metastatic disease in sinonasal adenocarcinomas of the intestinal subtype. © 2003 Wiley Periodicals, Inc. Head Neck 25: 763–771, 2003
Refinement of the free radial forearm flap reconstructive technique after resection of large oropharyngeal malignancies with excellent functional results
Authors: Moerman Mieke , Vermeersch Hubert , Van Lierde Kristiane , Fahimi Hossein , Van Cauwenberge Paul 
Published: September 2003

AbstractBackground.Wide resection of oropharyngeal malignancies implicates the risk of velopharyngeal insufficiency, which can cause nasal regurgitation and hypernasality. A meticulous reconstruction is necessary to avoid impairment and handicap in deglutition and speech. In the classic reconstructive techniques for large oropharyngeal defects, functional outcome only regards deglutition. We also focus on nasality, because hypernasality often occurs as a consequence in this type of reconstruction.Methods.In four patients, the surgical defect is closed with a free radial forearm flap sutured to the posterior side of the hard palate, thus imitating a caudally based pharyngeal flap. Speech is assessed by an independent speech pathologist, perceptually and acoustically. Deglutition is evaluated by a questionnaire and videofluoroscopy.Results.All patients had normal food intake. They did not report alterations in speech quality or verbal communication. Perceptual evaluation of articulation, voice, and nasality was optimal. Objective measurements with acoustical analysis and nasality scores confirmed the excellent functional outcome. Videofluoroscopy showed an unimpaired bolus transport with a complete velopharyngeal closure and optimal oral and pharyngeal clearance times.Conclusions.This meticulous reconstructive technique ensures an excellent functional outcome. The absence of nasality, in particular, proves the value of this refinement. The technique allows wide surgical margins and complete velopharyngeal closure. © 2003 Wiley Periodicals, Inc. Head Neck 25: 772–777, 2003
Sclerosing cervicitis: Report of a skull base lesion with literature review
Authors: Deussing Eric C. , Daroca Philip J. , Nemechek Andrew J. 
Published: September 2003

AbstractBackground.Invasive fibrosclerotic lesions of the head and neck outside of the thyroid and orbit are extremely rare. To date 13 cases of sclerosing cervicitis have been described in the literature.Methods.We present a case of a sclerosing inflammatory lesion encountered at the skull base in a 49‐year‐old woman.Results.After surgical excision and pathologic examination, this lesion was identified as sclerosing cervicitis.Conclusions.This case report contributes to an awareness of a rare lesion of the head and neck that presents clinical and treatment challenges for surgeons managing these patients. © 2003 Wiley Periodicals, Inc. Head Neck 25: 778–783, 2003
Crystalline Corrugation in Multilayer Films on Aqueous Subphases
Authors: Buller R. , Weissbuch I. , Cohen S. , Kjaer K. , Lahav M. , Leiserowitz L. 
Published: September 2003

AbstractA strong Bragg peak, attributed to regular corrugation in a crystalline film, was detected in a series of self‐assembled supramolecular complexes of bifunctional bolaamphiphiles of different lengths, with divalent ions of Pb and Cu, at the airaqueous interface. This peak has a d spacing half that of the proposed corrugation‐repeat length of ca. 82 Å, which is not a multiple of the long lattice spacing of the crystalline structure, and is susceptible to film compression. This corrugation is interpreted in terms of unfavorable interactions between the polar aqueous surface and the nonpolar hydrocarbon part of the bolaamphiphiles. To establish the nature of the corrugation, grazing‐incidence X‐ray diffraction and specular X‐ray reflectivity with synchrotron radiation were applied, as well as scanning force microscopy of films deposited on mica.
Synthesis and Enzymic Hydrolysis of Oligoribonucleotides Incorporating 3‐Deazaguanosine: The Importance of the Nitrogen‐3 Atom of Single Conserved Guanosine Residues on the Catalytic Activity of the Hammerhead Ribozyme
Authors: Seela Frank , Debelak Harald , Andrews Lori , Beigelman Leonid 
Published: September 2003

AbstractFour base‐modified hammerhead ribozyme/substrate complexes were constructed in which single guanosine (1) residues were replaced by 3‐deazaguanosine (2) in the positions G5, G8, GL2.1, and G12. The base‐modified ribozyme complexes were prepared by solid‐phase synthesis of oligoribonucleotides employing the novel phosphoramidite 3 derived from 2. Phosphoramidite 3 carried a phenoxyacetyl group at the amino function and a diphenylcarbamoyl residue at the oxo group of the nucleobase. The 2′‐hydroxy group was blocked with a triisopropylsilyl residue. Kinetic analysis of the phosphodiester hydrolysis showed a moderate decrease of the ribozyme catalytic activity when the residues G5 or G8 were replaced by 3‐deazaguanosine and a 200‐fold decrease when G12 was substituted. A 6‐fold catalytic increase occurred when 3‐deazaguanosine was replacing GL2.1 in the loop region. The data indicate that the N(3) atom of compound 2, in particular at position G12 is critical for the ribozyme activity.
Convergent Approaches to Saudin Intermediates
Authors: Cravero Raquel M. , González‐Sierra Manuel , Labadie Guillermo R. 
Published: September 2003

AbstractDifferent convergent approaches to the highly oxygenated sesquiterpene natural product saudin (1), has been investigated. Our strategy has included a Michael addition and aldol condensation reaction as key steps. During the synthetic development, we have found serious steric hindrance when an α‐Me‐substituted alkyl vinyl ketone was used. Such steric hindrance has been overcome by synthesizing the vinyl ketone 16 through an anionic fragmentation, which was carefully studied. Finally, the intermediate 18 has been synthesized in a one‐pot reaction from the vinyl ketone 16 and has been cyclized to obtain the promising tricyclic intermediate 20.
Synthesis of Novel (Phenylalkyl)amines for the Investigation of StructureActivity Relationships, Part 3
Authors: Trachsel Daniel 
Published: September 2003

AbstractAn easy and efficient pathway for the preparation of 4‐ethynyl‐2,5‐dimethoxyphenethylamine (=4‐ethynyl‐2,5‐dimethoxybenzeneethanamine; 2C‐YN; 1) was developed, an ethynyl analogue of the potent 5‐HT2A/C agonists, e.g., 4‐iodo‐2,5‐dimethoxy‐amphetamine (DOI; 2b). The ethynyl moiety was introduced by a Pd‐catalyzed Sonogashira reaction of (trimethylsilyl)ethyne with N‐(trifluoroacetyl)‐protected 4‐iodo‐2,5‐dimethoxyphenethylamine (7) in almost quantitative yield within only 1 h. Removal of the Me3Si group was accomplished with Bu4NF. Final N‐deprotection by NaOH treatment afforded the novel phenethylamine 1 in an overall yield of 88%.
Two New Insecticidal Amides and a New Alcoholic Amide from Piper nigrum Linn.
Authors: Siddiqui Bina S. , Gulzar Tahsin , Begum Sabira , Rasheed Munawwer , Sattar Fouzia A. , Afshan Farhana 
Published: September 2003

AbstractThree new amides, pipgulzarine (1), pipzorine (2), and piptahsine (3), have been isolated from the dried seeds of Piper nigrum Linn. along with nine known constituents: (2E,4E,8Z)‐N‐(isobutyl)eicosatrienamide, pellitorine, pipercide, piperine, stigmastanol, stigmasterol, decurrenal, stigmasterol 3‐O‐β‐D‐glucopyranoside, and 5,10(15)‐cadinen‐4‐ol. The structures of the new constituents have been established as (2E,11E)‐12‐(benzo[1,3]dioxol‐5‐yl)‐N‐(2‐methylpropyl)dodeca‐2,11‐dienamide (1), (2E,12Z)‐N‐(4‐methylpentyl)octadeca‐2,12‐dienamide (2), and (2E,4S)‐4‐hydroxy‐N‐(2‐methylpropyl)hex‐2‐enamide (3). The structures of 1–3 were derived by spectral studies and chemical reactions, and by comparison of spectral data in the case of known constituents. Compounds 1 and 2, and most of the already known compounds, exhibited toxicity against fourth instar larvae of Aedes aegypti Liston. The isolated (Z) double bond in 2 was assigned on the basis of its EI‐MS fragmentation pattern and its reaction with OsO4. The (S) configuration at C(4) of 3 was determined by Horeau's method. This is the first report of the isolation of a 4‐methylpentylamide from P. nigrum, while shorter branched amides have been reported from this genus [1].
Isolation and On‐Line LC/CD Analysis of 3,8″‐Linked Biflavonoids from Gnidia involucrata
Authors: Ferrari Julien , Terreaux Christian , Kurtán Tibor , Szikszai‐Kiss Attila , Antus Sándor , Msonthi Jerome D. , Hostettmann Kurt 
Published: September 2003

AbstractInvestigation of the methanol extract of the roots of Gnidia involucrata (Thymelaeaceae) led to the isolation and characterization of two new 3,8″‐biflavonoid diastereoisomers, named GB‐4 (6a) and GB‐4a (6b). Their absolute configurations were determined in mixture by on‐line LC/CD measurements, which also allowed the revision of absolute configurations of the biflavanoids GB‐1 and GB‐2, and the configurational assignment of GB‐3.
Competing Formations of Oxonium and Carbonyl Ylides with Carbonylcarbenes
Authors: Talinli E. Naciye , Anaç Olcay , Kumbaracı I. Volkan 
Published: September 2003

AbstractA series of 2‐mono‐ and 2,2‐disubstituted 1,3‐dioxepin derivatives, two of which also had a carbonyl function in one of their 2‐R groups, were prepared and reacted with dimethyl diazomalonate with copper(II) acetylacetonate as a catalyst. Ylide formation probabilities with allyl ether and/or carbonyl functions were investigated. A chemoselectivity in favor of carbonyl ylide was observed.
Triptowilfolide, a Novel Compound from Tripterygium wilfordii
Authors: Luo Duqiang , Zhang Xing , Tian Xuan , Liu Jikai 
Published: September 2003

AbstractA novel diterpenoid‐related compound, triptowilfolide (1), was isolated from the root bark of the Tripterygium wilfordii. Its structure was established by spectroscopic means.
Chemical Constituents of the Flowers of Azadirachta indica
Authors: Siddiqui Bina S. , Ali Syed Tariq , Rasheed Munawwer , Kardar Muhammad Nadeem 
Published: September 2003

AbstractStudies on the chemical constituents of the flowers of Azadirachta indica have led to the isolation of two new flavanones, flowerine (=5‐hydroxy‐7,4′‐dimethoxy‐8‐(3‐methylbut‐2‐enyl)flavan‐4‐one; 1) and flowerone (=5,7,8,4′‐tetrahydroxy‐3′‐(3‐methylbut‐3‐enyl)flavan‐4‐one; 2), and two new triterpenoids, O‐methylazadironolide (=7α‐(acetoxy)‐23ξ‐methoxy‐21,23‐epoxy‐24,25,26,27‐tetranorapotirucalla‐1,14,20(22)‐trien‐3,21‐dione; 3) and diepoxyazadirol (=(20S,23S,24R)‐7‐α‐(acetoxy)‐25‐hydroxy‐21,24 : 23,24‐diepoxyapotirucalla‐1,14‐dien‐3‐one; 4) along with the known triterpenoid trichilenone acetate (=7α‐(acetoxy)‐14,15 : 21,23‐diepoxy‐24,25,26,27‐tetranorapotirucalla‐1,20,22‐trien‐3‐one; 5), two known flavanones, nimbaflavone (=5,7‐dihydroxy‐4′‐methoxy‐8,3′‐bis(3‐methylbut‐2‐enyl)‐flavan‐4‐one; 6) and 3′‐prenylnaringenin (=5,7,4′‐trihydroxy‐3′‐(3‐methylbut‐2‐enyl) flavan‐4‐one; 7), and 4‐(2‐hydroxyethyl)phenol (8). Their structures have been elucidated through spectral studies, including 2D‐NMR experiments, and chemical transformation. Compounds 5, 7 and 8 are heretofore unreported from any part of tree, while 6 has been isolated earlier from leaves.
Chemical Constituents from the Roots of Schnabelia tetradonta
Authors: Dou Hui , Liao Xun , Peng Shu‐Lin , Pan Yuan‐Jiang , Ding Li‐Sheng 
Published: September 2003

AbstractThe new rearranged‐abietane diterpene 1, the four new triterpenoids 2–5, and the new aminoethylphenyl oligoglycoside 6, besides 19 known compounds, were isolated from the roots of Schnabelia tetradonta, a Chinese endemic herb. The structures of the new compounds were elucidated on the basis of spectroscopic evidence as 12,17‐epoxy‐11,14,16‐trihydroxy‐17(15→16)‐abeo‐abieta‐8,11,13,15‐tetraen‐7‐one (1), 21β‐(β‐D‐glucopyranosyloxy)‐2α,3α‐dihydroxyolean‐12‐en‐28‐oic acid (2), 2β,3β,16β‐trihydroxy‐15‐oxo‐28‐norolean‐12‐en‐23‐oic acid (3), 3β‐[(4‐O‐acetyl‐β‐D‐glucopyranuronosyl)oxy]‐2β,16β‐dihydroxy‐28‐norolean‐15‐oxo‐12‐en‐23‐oic acid (4), 3β‐[(4‐O‐acetyl‐6‐O‐methyl‐β‐D‐glucopyranuronosyl)oxy]‐2β,16β‐dihydroxy‐15‐oxo‐28‐norolean‐12‐en‐23‐oic acid (5), and 4‐[2‐(acetylamino)ethyl]phenyl O‐6‐O‐[(Z)‐p‐methoxycinnamoyl]‐β‐D‐glucopyranosyl‐(1→2)]‐O‐[β‐D‐glucopyranosyl‐(1→3)]‐4‐O‐acetyl‐α‐L‐rhamnopyranoside (6), respectively.
A Novel Synthetic Approach to (±)‐Desoxynoreseroline
Authors: Mekhael Maged K. G. , Heimgartner Heinz 
Published: September 2003

Abstract(±)‐Desoxynoreseroline (3), the basic ring structure of the pharmacologically active alkaloid physostigmine (1), was synthesized starting from 3‐allyl‐1,3‐dimethyloxindole (9). The latter was prepared from the corresponding 2H‐azirin‐3‐amine 6 by a BF3‐catalyzed ring enlargement via an amidinium intermediate 7 (Scheme 1). An alternative synthesis of 9 was also carried out by the reaction of N‐methylaniline with 2‐bromopropanoyl bromide (12), followed by intramolecular Friedel–Crafts alkylation of the formed anilide 13 to give Julian's oxindole 11. Further alkylation of 11 with allyl bromide in the presence of LDA gave 9 in an excellent yield (Scheme 3). Ozonolysis of 9, followed by mild reduction with (EtO)3P, gave the aldehyde 14, whose structure was chemically established by the transformation to the corresponding acetal 15 (Scheme 4). Condensation of 14 with hydroxylamine and hydrazine derivatives, respectively, gave the corresponding imine derivatives 16a–16d as a mixture of syn‐ and anti‐isomers. Reduction of this mixture with LiAlH4 proceeded by loss of ROH or RNH2 to give racemic 3 (Scheme 5).
Synthesis of Branched Oligonucleotides as Templates for the Assembly of Nanomaterials
Authors: Grimau Marta G. , Iacopino Daniela , Aviñó Anna , de la Torre Beatriz G. , Ongaro Andrea , Fitzmaurice Donald , Wessels Jurina , Eritja Ramon 
Published: September 2003

AbstractBranched oligonucleotides with symmetric arms 6–15, which may contain biotin as a second recognition code, were prepared. These molecules are designed to be used for the directed assembly of nanomaterials. The branched structure of the desired oligonucleotides was confirmed by mass spectrometry on small branched oliognucleotides, by gel electrophoresis, and by hybridization with complementary oligonucleotidenanoparticle conjugates, followed by visualization of the complexes by transmission electron microscopy.
Enzymatic Synthesis of Nucleoside‐5′‐O‐(1‐thiophosphates) and (SP)‐Adenosine‐5′‐O‐(1‐thiotriphosphate)
Authors: Barai Vladimir N. , Zinchenko Anatoli I. , Kvach Sergei V. , Titovich Olga I. , Rubinova Elena B. , Kalinichenko Elena N. , Mikhailopulo Igor A. 
Published: September 2003

AbstractTreatment of adenosine with PSCl3 in trimethyl phosphate gave, after ion‐exchange chromatography, adenosine‐5′‐O‐monophosphate (AMP; 28%) and adenosine‐5′‐O‐monothiophosphate (AMPS; 48%). AMPS was studied as a thiophosphate residue donor in an enzymatic transphosphorylation with nucleoside phosphotransferase (NPase) of the whole cells of Erwinia herbicola. As exemplified by a number of natural and sugar‐ and base‐modified nucleosides, it was demonstrated that NPase of the whole cells of Erwinia herbicola catalyzes the transfer of both thiophosphate and phosphate residues with a similar efficiency. An incubation of AMPS in a phosphorylating extract of Saccharomyces cerevisiae (K‐phosphate buffer (0.3 M, pH 7.0); 3% glucose; 15 mM MgCl2; 28°, 8 h), followed by ion‐exchange column chromatography afforded AMP (8%), AMPS (recovered, 23%), ATP (11%), and (SP)‐adenosine‐5′‐O‐(1‐thiotriphosphate) ((SP)‐ATPαS); (total yield 37%; 48% based on the consumed AMPS). For comparison of physicochemical properties, adenosine was chemically transformed into ATPαS as a mixture of the (SP) (53%) and (RP) (44%) diastereoisomers.
1,3‐Oxathiolanes from the Reaction of Aromatic and Enolized Thioketones with Monosubstituted Oxiranes
Authors: Fu Changchun , Linden Anthony , Heimgartner Heinz 
Published: September 2003

AbstractThe reactions of 4,4′‐dimethoxythiobenzophenone (1) with (S)‐2‐methyloxirane ((S)‐2) and (R)‐2‐phenyloxirane ((R)‐6) in the presence of a Lewis acid such as BF3⋅Et2O, ZnCl2, or SiO2 in dry CH2Cl2 led to the corresponding 1 : 1 adducts, i.e., 1,3‐oxathiolanes (S)‐3 with Me at C(5), and (S)‐7 and (R)‐8 with Ph at C(4) and C(5), respectively. A 1 : 2 adduct, 1,3,6‐dioxathiocane (4S,8S)‐4 and 1,3‐dioxolane (S)‐9, respectively, were formed as minor products (Schemes 3 and 5, Tables 1 and 2). Treatment of the 1 : 1 adduct (S)‐3 with (S)‐2 and BF3⋅Et2O gave the 1 : 2 adduct (4S,8S)‐4 (Scheme 4). In the case of the enolized thioketone 1,3‐diphenylprop‐1‐ene‐2‐thiol (10) with (S)‐2 and (R)‐6 in the presence of SiO2, the enesulfanyl alcohols (1′Z,2S)‐11 and (1′E,2S)‐11, and (1′Z,2S)‐13, (1′E,2S)‐13, (1′Z,1R)‐15, and (1′E,1R)‐15, respectively, as well as a 1,3‐oxathiolane (S)‐14 were formed (Schemes 6 and 8). In the presence of HCl, the enesulfanyl alcohols (1′Z,2S)‐11, (1′Z,2S)‐13, (1′E,2S)‐13, (1′Z,1R)‐15, and (1′E,1R)‐15 cyclize to give the corresponding 1,3‐oxathiolanes (S)‐12, (S)‐14, and (R)‐16, respectively (Schemes 7, 9, and 10). The structures of (1′E,2S)‐11, (S)‐12, and (S)‐14 were confirmed by X‐ray crystallography (Figs. 1–3). These results show that 1,3‐oxathiolanes can be prepared directly via the Lewis acid‐catalyzed reactions of oxiranes with non‐enolizable thioketones, and also in two steps with enolized thioketones. The nucleophilic attack of the thiocarbonyl or enesulfanyl S‐atom at the Lewis acid‐complexed oxirane ring proceeds with high regio‐ and stereoselectivity via an Sn2‐type mechanism.