bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in flower size and shape of Impatiens capensis is correlated with urbanization in Montreal, Canada
Authors: Faure Julie , Volz Valentine , Joly Simon 
Published: December 2023

AbstractUrbanization is changing the conditions in which many species live, forcing them to adjust to these novel environments. Floral size and shape are critical traits for the reproduction of plants pollinated by animals as they are involved in the attraction of pollinators and in efficient pollination. Variation in size and shape could be affected by urbanization via its modification of the abiotic environment (habitat fragmentation, water availability, temperature, soil properties), or via its impact on the biotic environment of plants (pollination, herbivory). Although numerous studies have assessed the impact of urbanization on pollinator communities and many plant traits, few have investigated its impact on floral size and shape while quantifying the proportion of the total urbanization effect that is due to biotic interactions. In this study, we tested if urbanization and pollinator visitation rates affect the flower shape of the spotted jewelweed, Impatiens capensis. We quantified the size and shape of flowers in frontal and profile views using geometric morphometrics for 228 individuals from six populations from the region of Montreal, Canada. Pollinator visitation rates were estimated at each site and the main pollinators were found to be bumblebees, honeybees and hummingbirds. We found that floral size and shape are significantly correlated with urbanization as measured by the amount of vegetation in the surrounding environment of the plants (mean normalized vegetation index, NDVI) and by the visitation rates of bumblebees and honey bees. Partitioning of the total flower shape variation suggests that urbanization affects flower shape through abiotic factors and via its impact on pollinator visitation rates. While further studies from other cities are necessary to confirm the role of urbanization in shaping the floral shape of I. capensis, these results support the idea that urbanization could affect flower shapes.
Ion mobility in gas and liquid phases: How much orthogonality is obtained in capillary electrophoresis–ion mobility–mass spectrometry?
Authors: Schairer Jasmin , Plathe Florian , Hudelmaier Sonja , Belau Eckhard , Pengelley Stuart , Kruse Lena , Neusüß Christian 
Published: December 2023

AbstractIon mobility–mass spectrometry (IM–MS) is an ever‐evolving tool to separate ions in the gas phase according to electrophoretic mobility with subsequent mass determination. CE is rarely coupled to IM–MS, possibly due to similar separation mechanisms based on electrophoretic mobility. Here, we investigate the orthogonality of CE and ion mobility (IM) by analyzing a complex peptide mixture (tryptic digest of HeLa proteins) with trapped ion mobility mass spectrometry (TIMS–MS). Using the nanoCEasy interface, excellent sensitivity was achieved by identifying thousands of peptides and achieving a peak capacity of 7500 (CE: 203–323 in a 150 cm long capillary, IM: 27–31). Plotting CE versus mass and CE versus (inverse) mobility, a clear grouping in curved striped patterns is observed according to the charge‐to‐size and mass‐to‐charge ratios. The peptide charge in the acidic background electrolyte can be estimated from the number of basic amino acids, with a few exceptions where neighboring effects reduce the positive charge. A surprisingly high orthogonality of CE and IM is observed, which is obviously caused by solvation effects leading to different charges and sizes in the liquid phase compared to the gas phase. A high orthogonality of CE and ion mobility is expected to be observed for other peptide samples as well as other substance classes, making CE–IM–MS a promising tool for various applications.
Empirical prediction intervals for additive Holt–Winters methods under misspecification
Authors: Yang Boning , Tang Xinyi , Yau Chun Yip 
Published: December 2023

AbstractHolt–Winters (HW) methods have been widely used by practitioners for the prediction of time series. However, traditional prediction intervals associated with the HW methods are only theoretically justified for a few types of SARIMA processes. In this article, we propose an empirical prediction interval for a general class of prediction procedures containing the HW methods as special cases. We establish the asymptotic validity of the prediction intervals under mild conditions, which allow model misspecification. Simulation experiments and an application to financial time series are provided to illustrate the good performance of the prediction intervals.
Performance of hybrid vaccine freezer that combined thermoelectric coolers with vapor compression refrigeration: Experimental assessment
Authors: Ashour Ali M. , Salman Ali D. , Al Jubori Ayad M. 
Published: December 2023

AbstractIn the medical field, refrigeration systems are used to store and transport vaccines, blood, and other medical supplies that require specific temperature ranges to remain effective. As technology continues to advance, the demand for more efficient and sustainable refrigeration systems is also increasing. The freezer compartment is typically designed to maintain a temperature of −18°C to −23°C for storing frozen items. Consequently, this work aims to develop a hybrid refrigeration system that combines a thermoelectric cooler system (TEC) and a vapor compression refrigeration cycle (VCC) system to achieve lower temperatures than conventional refrigerators. Also, the performance of the proposed hybrid refrigeration system is experimentally assessed with various operating conditions, including varying the voltage delivered to the system. The experimental results exhibited that the temperature inside the freezer room reached −33°C, while the cold side temperature is −47°C. Also, the maximum coefficient of performance of the VCC system, TEC, and hybrid system is 2.07, 1.06, and 0.37, respectively, at a DC voltage applied of 6 V. Moreover, the results revealed that the hybrid system combining a TEC and a VCC system can be a valuable technology for specific applications with low temperatures and limited capacity requirements.
Identification of Public Service Logic (PSL) and Public Service Motivation (PSM) elements in Open Government Data (OGD) initiatives
Authors: Ishengoma Fredrick , Shao Deo , da Silva Raphael Gouvêa , Wiedenhöft Guilherme Costa , Matheus Ricardo , Alexopoulos Charalampos , Rizun Nina , Saxena Stuti 
Published: December 2023

AbstractWhile previous research on Open Government Data (OGD) has primarily focused on reuse and adoption, this study aims to explore the implications of the Public Service Logic (PSL) and Public Service Motivation (PSM) dimensions in the context of OGD initiatives. This study is contextualized in Tanzania wherein the OGD initiatives are at an evolving stage. For the present study, the perspectives of the 15 public officials involved in the management of the OGD initiatives are being solicited. Findings underscore the need for furthering the marketing and refurbishing the OGD initiatives' quality alongside the increased involvement of the stakeholders to engage in value co‐creation. Furthermore, as a study contextualized in a developing country to understand the involvement of the public personnel in the refurbishment of the OGD initiatives, the study contributes to the extant OGD literature while identifying the OGD publisher‐side challenges and strengths in a still‐evolving OGD initiative. Finally, with its societal implications in terms of the impact on societal stakeholders' engagement with OGD given the PSL‐PSM of the public officials, the study's relevance is also clinched.
Implementing preemptive, multigene, pharmacogenomic testing in the inpatient setting: Preliminary results from a small, rural facility
Authors: Cole Jennifer L. 
Published: December 2023

AbstractIntroductionPreemptive pharmacogenomic (PGx) testing is on the rise among United States health care centers, with the majority of testing performed in the primary care setting. For broader implementation, there is a call for descriptions of the implementation and workflow of successful PGx programs in a large variety of health care settings.ObjectiveThe purpose of this study was to describe the implementation and initial outcomes of preemptive PGx (11‐gene, multipanel) testing in inpatient workflow at a Veterans Affairs medical center.MethodsThe inpatient clinical pharmacist incorporated patient screening, informed consent, and PGx lab ordering into their daily workflow in March 2023. Included adult patients had to be enrolled into the facility's primary care program and able to provide informed consent. Patients were excluded if they had a history of bone marrow or liver transplant, were consulted for palliative or hospice care, or had altered mental status at the time of screening. A retrospective chart review was used to collect demographics and PGx results from March to August 2023.ResultsThere were 247 patients screened for PGx testing in the 6‐month study period. Of these, 74 already had PGx performed, 31 declined or deferred testing, and 142 consented to testing. Laboratory blood draw was not performed as ordered on 12 patients, leaving 130 samples with results. Of 130 patients, 129 (99%) had an actionable PGx variant, with most having multiple variants: one variant (6%), two variants (15%), three variants (32%), four variants (24%), five variants (18%), and six variants (3%). At the time of follow‐up, 64 (49%) patients were prescribed an affected medication: one medication (38%), two medications (8%), and three medications (3%).ConclusionIncorporating preemptive PGx testing into inpatient workflow is feasible in a rural facility with a significant proportion of patients being affected by the results.
Epigallocatechin gallate alleviated the in vivo toxicity of ZnO nanoparticles to mouse intestine
Authors: Wang Canyang , Huang Chaobo , Cao Yi 
Published: December 2023

AbstractTo evaluate the oral toxicity of nanoparticles (NPs), it is necessary to consider the interactions between NPs and nutrient molecules. Recently, we reported that epigallocatechin gallate (EGCG), a healthy component in green tea, alleviated the toxicity of ZnO NPs to 3D Caco‐2 spheroids in vitro. The present study investigated the combined effects of EGCG and ZnO NPs to mice in vivo. Mice were administrated with 35 or 105 mg/kg bodyweight ZnO NPs with or without the presence of 80 mg/kg bodyweight EGCG via gastric route, once a day, for 21 days, and the influences of EGCG on the toxicity of ZnO NPs to intestine were investigated. We found that EGCG altered the colloidal properties of ZnO NPs both in water and artificial intestine juice. As expected, ZnO NPs induced toxicological effects, such as decreased bodyweight, higher Chiu's scores, and ultrastructural changes in intestine, whereas EGCG alleviated these effects. Combined exposure to EGCG and ZnO NPs also changed trace element levels in mouse intestine. For example, the levels of Ti, Co, and Ni were only significantly elevated after co‐exposure to EGCG and ZnO NPs, and Fe levels were only significantly decreased by ZnO NPs. Western blot analysis suggested that tight junction (TJ) and endoplasmic reticulum (ER) proteins were elevated by ZnO NPs, but EGCG inhibited this trend. Combined, these data suggested that gastric exposure to ZnO NPs induced intestinal damage, trace element imbalance, and TJ/ER protein expression in mouse intestine, whereas EGCG alleviated these effects of ZnO NPs.
Performance assessment of an injectable hyaluronic acid/polylactic acid complex hydrogel with enhanced biological properties as a dermal filler
Authors: Zhao Jiajing , Chen Ziwei , Li Xiaoshuo , Tong Zheren , Xu Zijin , Feng Peishi , Wang Ping 
Published: December 2023

AbstractInjectable hyaluronic acid (HA) hydrogel plays an important role in dermal filling. However, conventional HA dermal fillers mostly lack bio‐functional diversity and frequently cause adverse reactions because of the chemical stiffness of highly modified degree and crosslinker residues. In this study, polylactic acid (PLA) was embedded into HA hydrogel as a bioactive substance and 1,4‐butanediol diglycidyl ether was used as a crosslinker to prepare the HA/PLA composite hydrogel with enhanced biocompatibility and biological performance. We aimed to investigate the properties of HA/PLA composite hydrogels as dermal fillers by assessing the rheological properties, surface microstructure, enzymolysis stability, swelling ratio, degradation rate, cytotoxicity, and anti‐wrinkle effect on photo‐aged skin. The results showed that the stability and stiffness of the composite hydrogel decreased with an increasing amount of PLA, while the in vivo safety of the HA/PLA hydrogel was enhanced, showing no adverse reactions such as edema, redness, or swelling. Moreover, the composite hydrogel with 2 wt% PLA exhibited excellent anti‐wrinkle effects, showing the highest collagen production. Thus, the PLA‐embedded HA composite hydrogel showed potential as a dermal filler with high safety, easy injectability, and excellent anti‐wrinkle effects.
Upadacitinib in end stage renal disease: A case of acute severe ulcerative colitis
Authors: Hilley Patrick , Con Danny , Choy Matthew C. , Srinivasan Ashish , De Cruz Peter 
Published: December 2023

AbstractRecent data, indicating that inflammatory bowel disease (IBD) may be a risk factor for future chronic kidney disease, highlight the need to study the safety and clinical effectiveness of advanced IBD therapies in patients with end stage renal disease (ESRD), defined as an eGFR <15 mL/min/1.73m2. Upadacitinib, a selective oral Janus kinase (JAK) 1 inhibitor, has demonstrated efficacy in the management of moderate to severe ulcerative colitis. There is also emerging data indicating that JAK inhibition may be clinically effective in the setting of steroid‐refractory acute severe ulcerative colitis (ASUC). There is, however, a lack of “real‐world” data documenting the use of JAK inhibitors in patients with ESRD. Here, we report the use of upadacitinib in a patient with ESRD for the management of steroid‐refractory ASUC, demonstrating, for the first time, the safe and clinically effective use of upadacitinib in this population.
4‐substituted push‐pull quinazoline chromophores with extended π‐conjugated linker
Authors: Bonnaud Thibault , Scaviner Mathieu , Robin‐le Guen Françoise , Achelle Sylvain 
Published: December 2023

AbstractA series of four push‐pull compounds based on a 4‐phenylquinazoline scaffold were designed. Three of these compounds exhibit dual state emission with intense fluorescence in solution and solid state. Their emission properties are sensible to environement stimuli with intense emission solvatochromism and halochromism. In case of methoxy derivative, both neutral and protonated form are luminescent and white light emission can be observed by controlled partial protonation.
Impact of temperature variation on linearity parameters of nanotube surrounding gate (NT‐SG) MOSFETs
Authors: Garg Nitin , Pandey Ashish , Pandey Avanish Kumar , Tyagi Ashutosh , Singh Aniket Pratap 
Published: December 2023

AbstractThe work investigates the effect of temperature variation on the linearity performance of Nanotube Junctionless Surrounding Gate (NT‐SG) MOSFET. In this study, the linearity parameters of NT‐SG MOSFET is investigated by changing the temperature range from 300 to 500 K using the Silvaco 3D Simulator. For the specified temperature range, characteristics including high‐order trans‐conductance (gm2 and gm3), IIP3, VIP3, and VIP2 have been assessed. All of these metrics exhibit great linearity and little distortion at the NT‐SG MOSFET's zero crossover point for Vds = 0.01 V. The VIP2 and VIP3 are found to be increased when the temperature range increases from 300 to 500 K and thus the device is found to be more suitable for high‐frequency applications. In addition to this, the NT‐SG MOSFET manifests enhanced analog performance and is also more immune toward SCEs.
Metal cation‐induced conformational changes of soybean protein isolate/soybean soluble polysaccharide and their effects on high‐internal‐phase emulsion properties
Authors: Zhao Guilan , Wang Shengnan , Li Yangyang , Liu Xiulin , Yang Lina , Song Hong , Liu He 
Published: December 2023

AbstractBACKGROUNDMetal ions commonly inevitably appear in food products and have adverse effects on high‐internal‐phase emulsions (HIPEs) foods, but conformational conversion of soybean protein isolate (SPI)/soybean soluble polysaccharide (SSPS) on the interface layer of HIPEs influenced by different metal ions has rarely been reported.RESULTSHere, the conformational conversion of SPI/SSPS induced by Na+, K+, Ca2+, Mg2+ and Fe3+ ions and its effects on HIPEs were investigated. After adding the ions to SPI and SPI/SSPS dispersions, the particle size and zeta potential results showed different degrees of flocculation; the zeta potential and Fourier transform infrared spectra indicated that SPI and SPI/SSPS changes in structure involve electrostatic interactions and hydrogen bonding. Moreover, Raman spectra showed that the content of β‐sheet of SPI/SSPS HIPEs increased with the addition of Ca2+, Mg2+ and Fe3+, suggesting that SPI molecules at the interface formed a more orderly structure. The ultraviolet and fluorescence results showed that the hydrophobic environment of tryptophan and tyrosine residues inside protein molecules played a vital role in the emulsifying stability of SPI.CONCLUSIONThese findings suggested that the SPI/SSPS complexes for food applications were not susceptible to ions, thus ensuring complex stability, showing potential for commercial application in the production of emulsions. © 2023 Society of Chemical Industry.
Agroclimatic mapping for olive cultivation in Brazil: pinpointing optimal growing regions
Authors: de Oliveira Aparecido Lucas Eduardo , Torsoni Guilherme Botega , de Lima Rafael Fausto , Mesquita Daniel Zimmermann , Peche Pedro Maranha 
Published: December 2023

AbstractBACKGROUNDThis research aimed to identify the agroclimatic zones in Brazil, excluding Rio Grande do Sul, that are suitable for olive (Olea europaea L.) cultivation, considering both climatic and topographical factors. Olives require specific conditions: moderate winter temperatures (7–15 °C), warmer summers (25–35 °C) and sufficient water during growth and fruit maturation. They can endure some drought, making them a viable option for agricultural diversification. Using daily meteorological data from 1989 to 2023 from NASA‐POWER, this study analyzed variables like air temperature (minimum and maximum) and rainfall. Key climate variables were the mean air temperature in winter (T_w), spring (T_s), summer (T_su) and autumn (T_a) and total annual precipitation (Prec). Criteria for suitability included: T_w between 5 and 20 °C, T_s between 15 and 23 °C, T_su between 15 and 30 °C, T_a between 15 and 22 °C, annual precipitation over 900 mm and altitude below 900 m. Geographic information system software and Python 3.8 were employed for data analysis and zoning.RESULTSResults indicated that only 1.92% of the analyzed area, mainly in Minas Gerais, was suitable for olive cultivation. High temperatures and low rainfall in Brazil, particularly in the North and Midwest, make 59.56% of the country unsuitable for olive farming. Additionally, 18.58% of the land, mainly in the Northeast, faces challenges due to extreme heat (T_w) and insufficient water supply. © 2023 Society of Chemical Industry.
Spatiotemporal heterogeneity of soil available nitrogen during freeze–thaw cycles in a watershed: A 3‐year investigation
Authors: Zhang Shaoliang , Aurangzeib Muhammad , Xiao Ziliang , Wang Hao , Xu Weitao 
Published: December 2023

AbstractThe spatial pattern of soil available nitrogen (AN) is the key reference for farmland fertilization however, it is still unclear how freeze–thaw cycles (FTC) altered the spatiotemporal heterogeneity of AN at the watershed scale. In this study, the geostatistical, traditional analysis and structural equation models were used to detect how topography, land management, and soil properties influence the spatiotemporal heterogeneity of AN in both before‐ and after FTCs of Mollisols of a watershed in Northeast China for three consecutive years. The results showed that AN decreased in >88% of areas of the watershed after FTCs, and the mean value significantly decreased by >7.6% (>10.4 mg kg−1) in 0–20 cm soil depth during 2016–2017 years and 2017–2018 years. The AN distribution, especially in the surface soil layer, tended to be aggregated after FTCs. The AN decreased in the areas near the areas of top slope position, while it tended to increase in areas of downslope position covered by forest although the total N decreased here after FTCs. The AN‐change (ANbefore FTCs minus ANafter FTCs) influenced by land use types was greater than slope steepness. The slope aspect as the key factor combined with slope steepness, slope position, and previous crops influenced the spatiotemporal heterogeneity of AN‐change after FTCs. The higher content of AN before FTCs accelerated more N loss during FTCs, and this process was mainly influenced by soil pH, nitrogen (N), and phosphorus. The N loss (5.7%) did not significantly alter the AN‐change after FTCs in the watershed. Generally, the spatial heterogeneity of AN‐change was mainly influenced by topography, land management, and soil properties (before FTCs) during FTCs in the watershed. In order to sustain a high level of AN, the mediation of N transformation and both vertical‐ and horizontal migration, caused by the dynamics of soil water potential and snowmelt erosion should be considered during FTCs.
The perceived ecological and human well‐being benefits of ecosystem restoration
Authors: Jurjonas Matthew , May Christopher A. , Cardinale Bradley , Kyriakakis Stephanie , Pearsall Douglas R. , Doran Patrick J. 
Published: December 2023

Abstract

Traditionally, ecosystem restoration has focussed on standard ecological indicators like water or habitat quality, species population abundance or vegetation cover to determine success. However, there is growing interest in how restoration might impact people and communities. For example, researchers have documented positive socio‐ecological links between restoration and human well‐being indicators like property value, natural hazard mitigation, recreation opportunity and happiness. Furthermore, public health benefits from restoration have been linked to public support for programmes.

Drawing from this research, the United Nations declared 2021–2030 the ‘Decade of Ecosystem Restoration’ and set a goal to promote more socio‐ecological goals in ecosystem restoration. Nonetheless, there is still a lack of information on the extent to which restoration practitioners consider well‐being because many granting programmes only require ecological goals and monitoring.

To explore how restoration practitioners design, implement and measure the success of their projects, we used the federally funded Great Lakes Restoration Initiative (GLRI) as a case study. Since 2010, GLRI has awarded over $3.5 Billion to over 5300 projects across the midwestern United States, but it does not presently require human well‐being considerations. We performed an online survey targeting project managers with a sample of GLRI projects (N = 1574). We received 437 responses and found that almost half set a human well‐being goal, and more than 70% of those who did believe they reached it. In comparison, 90% of project managers believed they met their ecological goals.

These documented perceptions of positive impacts for both people and nature suggest that restoration may already transcend traditional indicators and monitoring for socio‐ecological metrics could capture many ‘unseen’ benefits. Therefore, we recommend that ecosystem restoration programmes adopt a socio‐ecological lens to document the full extent of their restoration outcomes.

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