bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the impact of critical attributes on hard drive failure times: Multi‐state models for left‐truncated and right‐censored semi‐competing risks data
Authors: Oakley Jordan L. , Forshaw Matthew , Philipson Pete , Wilson Kevin J. 
Published: December 2023

AbstractThe ability to predict failures in hard disk drives (HDDs) is a major objective of HDD manufacturers since avoiding unexpected failures may prevent data loss, improve service reliability, and reduce data center downtime. Most HDDs are equipped with a threshold‐based monitoring system named self‐monitoring, analysis and reporting technology (SMART). The system collects several performance metrics, called SMART attributes, and detects anomalies that may indicate incipient failures. SMART works as a nascent failure detection method and does not estimate the HDDs' remaining useful life. We define critical attributes and critical states for hard drives using SMART attributes and fit multi‐state models to the resulting semi‐competing risks data. The multi‐state models provide a coherent and novel way to model the failure time of a hard drive and allow us to examine the impact of critical attributes on the failure time of a hard drive. We derive dynamic predictions of conditional survival probabilities, which are adaptive to the state of the drive. Using a dataset of HDDs equipped with SMART, we find that drives are more likely to fail after entering critical states. We evaluate the predictive accuracy of the proposed models with a case study of HDDs equipped with SMART, using the time‐dependent area under the receiver operating characteristic curve (AUC) and the expected prediction error (PE). The results suggest that accounting for changes in the critical attributes improves the accuracy of dynamic predictions.
Circumstellar disk and the first generation of stars
Authors: Riaz Rafeel 
Published: December 2023

AbstractCircumstellar disk (CD) around the first generation of stars have been numerically investigated here to see if the cooling regimes also play a role in the formation and evolution of the disk associated with the most massive protostars (MMPS). Also, an emphasis is given to exploring the effect of the initial turbulent motion of the metal‐free gas on the resulting morphology of the CD. For this, a systematic range of Mach number has been examined. It has been found that the disk‐to‐star mass ratio / is larger when the model evolution is based on the first H line cooling followed by subsequent cooling via collision‐induced emission than in the model where only H line cooling remains operative. Also, irrespective of the initial turbulence in the cloud, the former type of model yields a CD as massive as 7.66 M while the latter type produces a disk as massive as 1.29 M. Moreover, the inner part of the CD is found dominated by higher subsonic turbulent motions in the case of the former type of models than in the latter type. CDs around MMPS in both types of models show stable disk structures.
Recent advances in aggregation‐induced emission–active type I photosensitizers with near‐infrared fluorescence: From materials design to therapeutic platform fabrication
Authors: Xie Yili , Li Zhijia , Zhao Chunhui , Lv Ruizhi , Li Yan , Zhang Zhihong , Teng Muzhou , Wan Qing 
Published: December 2023

AbstractNear‐infrared (NIR) fluorescence imaging–guided photodynamic therapy (PDT) technology plays an important role in treating various diseases and still attracts increasing research interests for developing novel photosensitizers (PSs) with outstanding performances. Conventional PSs such as porphyrin and rhodamine derivatives have easy self‐aggregation properties in the physiological environment due to their inherent hydrophobic nature caused by their rigid molecular structure that induces strong intermolecular stacking π–π interaction, leading to serious fluorescence quenching and cytotoxic reactive oxygen species (ROS) reduction. Meanwhile, hypoxia is an inherent barrier in the microenvironment of solid tumors, seriously restricting the therapeutic outcome of conventional PDT. Aforementioned disadvantages should be overcome urgently to enhance the therapeutic effect of PSs. Novel NIR fluorescence–guided type I PSs with aggregation‐induced emission (AIE), which features the advantages of improving fluorescent intensity and ROS generation efficiency at aggregation as well as outstanding oxygen tolerance, bring hope for resolving aforementioned problems simultaneously. At present, plenty of research works fully demonstrates the advancement of AIE‐active PDT based on type I PSs. In this review, cutting‐edge advances focusing on AIE‐active NIR type I PSs that include the aspects of the photochemical mechanism of type I ROS generation, various molecular structures of reported type I PSs with NIR fluorescence and their design strategies, and typical anticancer applications are summarized. Finally, a brief conclusion is obtained, and the underlying challenges and prospects of AIE‐active type I PSs are proposed.
Agar plate‐based activity assay for easy and fast screening of recombinant Pichia pastoris expressing unspecific peroxygenases
Authors: Schmitz Fabian , Röder Annika , Hoffrogge Maike , Urlacher Vlada B. , Koschorreck Katja 
Published: December 2023

AbstractUnspecific peroxygenases (UPOs) are promising biocatalysts that catalyze oxyfunctionalization reactions without the need for costly cofactors. Pichia pastoris (reclassified as Komagataella phaffii) is considered an attractive host for heterologous expression of UPOs. However, integration of UPO‐expression cassettes into the genome via a single cross‐over yields recombinant Pichia transformants with different UPO gene copy numbers resulting in different expression levels. Selection of the most productive Pichia transformants by a commonly used screening in liquid medium in 96‐well plates is laborious and lasts up to 5 days. In this work, we developed a simple two‐step agar plate‐based assay to screen P. pastoris transformants for UPO activity with less effort, within shorter time, and without automated screening devices. After cell growth and protein expression on agar plates supplemented with methanol and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), an additional top agar layer supplemented with ABTS and peroxide is added. UPO activity is visualized within 15 min by formation of green zones around UPO‐secreting P. pastoris transformants. The assay was validated with two UPOs, AbrUPO from Aspergillus brasiliensis and evolved PaDa‐I from Agrocybe aegerita. The assay results were confirmed in a quantitative 96‐deep well plate screening in liquid medium.
Consumers' textile disposal practices and their perceived value in the circular economy: A platform focused ethnography approach
Authors: Pera Rebecca , Ferrulli Eliana 
Published: December 2023

AbstractThis study builds on the Circular Economy paradigm which recognises consumers as key stakeholders in extending textiles' lifespan. The paper unfolds how consumers engage in the textile disposal practices of reuse, repair, donate and resell. In doing so, consumers create a value‐in‐disposition, here conceptualised as the enhanced value that consumers generate through the process of transforming depleted textiles into new meaningful ones. This research adopts a multimethod platform focused ethnography that combines textual, visual and audio data, generated in the domestic environment, which facilitates contextual and situational insights. The findings highlight that value‐in‐disposition goes far beyond the utilitarian aspects (e.g. economic or functional) and includes social, aesthetic, emotional and moral value dimensions, which contribute in building an overarching environmental value. The study shows that consumer disposal practices not only reduce waste but also favour consumer empowerment through the transformation of unused/depleted resources into new value. Finally, the article provides specific managerial insights on the design of textile products and services to encourage consumer engagement in reuse, repair, donation, and resell practices, supporting companies in the Circular Economy uptake.
Ten tips for successful assessment of risk of bias in randomized trials using the RoB 2 tool: Early lessons from Cochrane
Authors: Moore Theresa H. M. , Higgins Julian P. T. , Dwan Kerry 
Published: December 2023

AbstractIntroductionRoB 2 is a tool used by systematic reviewers to assess risk of bias in randomized trials. Over a period of 19 months working as editors for Cochrane, we saw many instances where users of RoB 2 frequently applied the tool in ways the developers had not intended, despite availability of detailed guidance, webinars and FAQs.MethodsIn this paper we highlight the ten main issues that we observed, with the aims of optimising the application of the RoB 2 tool, avoiding some of the frequent misapplications of the tool.ResultsIssues noted included failure to state an effect of interest, applying the tool to an entire study rather than to a specific numerical result, omitting key signaling questions and relying on outdated views of causes of bias.ConclusionSuch omissions and misapplications can lead to overly harsh or lenient assessments of bias with potential to change the confidence we have in an evidence base of randomized trials. We recommend that teams planning to use RoB 2 include at least one member familiar with the RoB 2 detailed guidance and that they use the free resources, such as webinars and FAQs, from the developers of RoB 2 and Cochrane. Our ten tips should be useful to non‐Cochrane systematic reviewers as well as to peer reviewers and editors in Cochrane and other journals.
Conventional maxillary denture versus maxillary implant‐supported overdenture opposing mandibular implant‐supported overdenture: Patient's satisfaction
Authors: Niakan Somayeh , Mahgoli Hosseinali , Afshari Aylar , Mosaddad Seyed Ali , Afshari Aysooda 
Published: December 2023

AbstractObjectivesThis study sought to determine the impact of age, gender, and use of maxillary implant‐supported overdenture (UISOD) versus conventional denture (CMD) opposing mandibular implant‐supported overdenture (LISOD) and the number of years the patient has used their prosthesis on the ratings of satisfaction. This study aimed to assess the long‐term influence of different factors on patients' satisfaction with LISODs needing a maxillary prosthesis, helping dentists choose a treatment pathway that leads to a higher satisfaction rate.Material and MethodsThis cross‐sectional study included 84 participants. They were treated with LISOD opposing either CMD or UISOD from 2015 to 2020. They were all eligible to participate in the study. An oral health impact profile (OHIP‐14) questionnaire was given to each patient and filled out by them. OHIP‐14 scores were gathered and went under statistical analysis with PASS‐11 software to determine the relationship between patients' satisfaction with the scores.ResultsAge and gender had no significant influence on how satisfied patients were. Patients with maxillary overdentures showed more satisfaction than the CMD group (p < .05). Moreover, patients' satisfaction decreased with increasing years of prostheses usage (p < .05).ConclusionsThis study demonstrated that satisfaction is related to the type of maxillary prosthesis (conventional or implant‐supported) used opposing LISODs and the number of years the patient had used the prostheses.
Understanding sensitivity and cross‐reactivity of xylazine lateral flow immunoassay test strips for drug checking applications
Authors: Sisco Edward , Nestadt Danielle F. , Bloom Madeline B. , Schneider Kristin E. , Elkasabany Rae A. , Rouhani Saba , Sherman Susan G. 
Published: December 2023

AbstractThe continued prevalence of xylazine in the illicit drug market has necessitated development of quick and simple methods for identification, including lateral flow immunoassays (also known as “test strips”), like those frequently used to detect fentanyl. This study explored the drug checking applicability of the first publicly available xylazine test strips (XTS) using four sub‐studies: reproducibility (i.e., consistency of positive results in a highly‐concentrated xylazine solution); limit of detection on a calibration curve of xylazine concentrations; cross‐reactivity against 77 commonly encountered drugs, cutting agents, and other structurally similar compounds; and applicability for analyzing community‐acquired samples—where 100 drug residue samples were analyzed using XTS, direct analysis in real time mass spectrometry (DART‐MS), and gas chromatography tandem mass spectrometry (GC–MS/MS). XTS consistently detected xylazine at concentrations ≥2.5 μg/ml, and XTS results were reproducible. Sensitivity and specificity of XTS were calculated by comparing expected versus obtained results based on xylazine concentration of community‐acquired samples measured by GC‐MS/MS. XTS consistently detected xylazine in samples with concentration >2 μg/ml and yielded a sensitivity of 0.974, specificity of 1.00, and overall accuracy of 0.986. Cross‐reactivity with lidocaine, a common cutting agent, and lack of XTS reactivity with other α2‐agonists found in the illicit drug supply highlight the need to offer consumers comprehensive drug checking services that identify a range of substances and better inform them about drug contents.
The treatment of dissociative identity disorder in an eating disorder residential treatment setting
Authors: Brewerton Timothy D. , Perlman Molly M. , Gavidia Ismael , Suro Giulia 
Published: December 2023

AbstractObjectiveChild maltreatment, dissociation and dissociative disorders have been noted in relationship to eating disorders (EDs) for decades, and their co‐occurrence generally is associated with greater morbidity, self‐harm and mortality. The concomitant presentation of dissociative identity disorder (DID) with an ED (ED + DID) is especially challenging, and there is limited information on approaches to and the effects of integrated treatment for this serious comorbidity, especially in higher levels of care. There are also limited treatment resources for such patients, since they are often turned away from specialty units due to lack of expertise with or bias toward one or the other disorder.MethodWe report our experience with a case series of 18 patients with DSM‐5 defined ED + DID (mean age (SD) = 32.6 (11.8) years) admitted to residential treatment (RT) and assessed using validated measures for symptoms of ED, major depression (MD), PTSD, state–trait anxiety, quality of life (QOL), age of ED onset, and family involvement during treatment. All patients received integrated, multimodal, trauma‐focused approaches including those based on DID practice guidelines, principles of cognitive processing therapy (CPT), and other evidence‐based approaches. Fifteen of 18 patients also completed discharge reassessments, which were compared to admission values using paired t‐tests.ResultsFollowing integrated, trauma‐focused RT, patients with ED + DID demonstrated statistically significant improvements in all measures, with medium (anxiety) to high (ED, PTSD, MD, QOL) effect sizes.DiscussionThese results provide positive proof of concept that patients with ED + DID can be effectively treated in a specialty, trauma‐focused ED program at higher levels of care.Public SignificanceEDs and dissociative identity disorder (DID) are related conditions, but little is known about treating patients with both conditions. We describe the clinical features and integrated treatment of 18 such patients, 15 of whom completed discharge assessments. Significant clinical improvements were found in multiple domains (ED, PTSD, mood, anxiety, quality of life), which demonstrate positive proof of concept that ED + DID can be effectively treated in a specialty, trauma‐focused ED program.
Assessing habitat quality at Poyang Lake based on InVEST and Geodetector modeling
Authors: Yuan Wenrui , Chen Lingkang , Chen Haixia , Deng Shaofu , Ji Hong , Liang Fenshuo 
Published: December 2023

AbstractPoyang Lake is an essential natural wetland in the Yangtze River basin and plays a vital role in maintaining the ecosystem function and ecological security in the middle and lower reaches of the Yangtze River. However, the relative importance and spatial heterogeneity of the impacts of human activities and land use changes on ecological security needs to be further explored. Here, we analyzed the habitat quality level around Poyang Lake in 2022 and explored the factors of habitat quality change from a geographical perspective. The land use structure changes around the Poyang Lake basin from 2000 to 2022 were quantitatively analyzed, and then the relative importance and spatial heterogeneity of each factor on ecological security changes were investigated using geographic probes. The results show that (1) The worst quality habitat (0–0.1) consists mainly of construction land (1624.9 km2) with an area of 1634.64 km2; (2) Construction land continues to increase with the most significant change, and the dynamic land use attitude is 0.47. Grassland and mudflats have the greatest decrease. The increase in cultivated land in different periods is mainly due to the shift of water surface and forest land; (3) The drivers of habitat quality in Poyang Lake were significantly influenced by the interaction of socioeconomic factors. The explanatory power of population density interacting with the total year‐end population and population density interacting with administrative area exceeded 0.84. These values were higher than the explanatory power of each individual factor, indicating that habitat quality was primarily associated with population density, total year‐end population, and administrative area. These results suggest that human activities contribute to the degradation of wetlands around Poyang Lake. This study has significant reference value for coordinating human–land relationships in Poyang Lake, optimizing land management policy, and improving the sustainable development of cities.
Zfp36l1 establishes the high‐affinity CD8 T‐cell response by directly linking TCR affinity to cytokine sensing
Authors: Petkau Georg , Mitchell Twm J. , Evans Marian Jones , Matheson Louise , Salerno Fiamma , Turner Martin 
Published: December 2023

AbstractHow individual T cells compete for and respond to IL‐2 at the molecular level, and, as a consequence, how this shapes population dynamics and the selection of high‐affinity clones is still poorly understood. Here we describe how the RNA binding protein ZFP36L1, acts as a sensor of TCR affinity to promote clonal expansion of high‐affinity CD8 T cells. As part of an incoherent feed‐forward loop, ZFP36L1 has a nonredundant role in suppressing multiple negative regulators of cytokine signaling and mediating a selection mechanism based on competition for IL‐2. We suggest that ZFP36L1 acts as a sensor of antigen affinity and establishes the dominance of high‐affinity T cells by installing a hierarchical response to IL‐2.
Status of epilepsy care delivery and referral in clinics, hospitals, and epilepsy centers in Japan: A nationwide survey
Authors: Tokumoto Kentaro , Terada Kiyohito , Kawaguchi Norihiko , Nishida Takuji , Yamano Mitsuhiko , Aoyagi Tomoo , Tadokoro Yuji , Usui Naotaka , Inoue Yushi 
Published: December 2023

AbstractObjectiveCollaboration among medical facilities is crucial to deliver comprehensive epilepsy care to a diverse and large population of people with epilepsy. We conducted a survey among medical facilities of various sizes throughout Japan to investigate the status of epilepsy care delivery, functioning, and referral.MethodsWith the cooperation of the Japan Neurological Society (1428 facilities), Japanese Neurosurgical Society (3489 specialists), and Epilepsy Care Network (948 facilities), a questionnaire was mailed to 5865 locations that provide epilepsy care in Japan. The facilities were classified into clinics (19 beds or less), small hospitals (SH, 20–199 beds), large hospitals (LH, 200 beds or more), and epilepsy centers (EC). The status of epilepsy care delivery, functioning, and referral was compared among the four groups.ResultsResponses were received from 1014 facilities (17.3% response rate). After excluding duplicate responses, 957 facilities were analyzed (394 clinics, 149 SH, 388 LH, 26 EC). EC responded “manageable” in more items of epilepsy care functions in general, especially those related to epilepsy surgery, compared to LH with similar facility size. However, EC responded being less manageable in psychiatric service (61.5%), dietary therapy (46.2%), rehabilitation (53.8%), and patient employment support (61.5%). The percentage of facilities that responded “always able to refer” was highest in clinics (67.6%) and the lowest in EC (40%). Referral difficulties were more commonly encountered in EC, and less common in clinics. In EC, the most common reason for inability to refer was patient or family refusal (64%).SignificanceWe have clarified the epilepsy care delivery, functioning, and referral in facilities of various sizes in Japan. This study highlights the issues of downward referral and patient stagnation in EC, which have not received much attention.Plain Language SummaryA nationwide survey of healthcare facilities ranging in size from small clinics to large hospitals in Japan examined medical care delivery and patient referrals related to epilepsy. Compared to other facilities, epilepsy centers provided a variety of medical services to people with epilepsy but were inadequate in addressing psychiatric symptoms, providing dietary therapy, rehabilitation, and patient employment support. Referrals from epilepsy centers to other medical facilities were often refused by patients and their families. This results in patient crowding at epilepsy centers
RAKSHAM: Responsive approach to Knock‐off scavenging hackers and attack mitigation
Authors: Bhardwaj Sonam , Dave Mayank 
Published: December 2023

AbstractWith the increasing interconnectivity of devices and systems in the Internet of Things (IoT) landscape, the importance of cybersecurity has grown significantly. This work presents a comprehensive solution that combines deceptive techniques and AI‐based detection to strengthen the security of IoT networks against sophisticated cyber threats. Deceptive techniques, such as the utilization of honeypots, deceptive IoT devices, and deceptive network traffic, are deliberately employed with the aim of misleading potential attackers. However, the effectiveness of these systems is often challenged by highly skilled attackers and the complexities associated with allocating resources. To address these challenges, “RAKSHAM” is a unique approach to improving the security of IoT networks. It combines deceptive techniques with AI‐based detection mechanisms, minimizing false positives and operational outages in IoT networks. This approach utilizes Eigenvector Centrality (EVC) to identify nodes with a higher risk level. It also evaluates the performance of an AI‐based attack detection model. The AI model, which utilizes a Convolutional Neural Network (CNN), demonstrates exceptional efficacy in the detection of attacks with 99% accuracy and a minimal attack success probability rate of 0.10. RAKSHAM offers a pragmatic and efficient solution for securing IoT networks by accurately detecting attacks and minimizing false positives and operational outages.