bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and validation of a prognostic signature based on seven endoplasmic reticulum stress-related lncRNAs for patients with head and neck squamous cell carcinoma
Authors: Zhou Mingzhu , Li Huihui , Hu Juanjuan , Zhou Tao , Zhou Liuqing , Li Yuncheng 
Published: December 2023

AbstractEndoplasmic reticulum stress (ERS) occurs when misfolded or unfolded proteins accumulate in the endoplasmic reticulum (ER), and it is often observed in tumors, including head and neck squamous cell carcinoma (HNSCC). Relevant studies have demonstrated the prognostic significance of ERS-related long non-coding RNAs (lncRNAs) in various cancers. However, the relationship between ERS and lncRNAs in HNSCC has received limited attention in previous studies. In this study, we aimed to develop an ERS-related lncRNAs prognostic model using correlation analysis, Cox regression analysis, least absolute shrinkage, and selection operator (LASSO) regression analysis based on data from The Cancer Genome Atlas (TCGA) database. The survival and predictive ability of this model were evaluated using Kaplan–Meier analysis and time-dependent receiver operating characteristics (ROC), while nomograms and calibration curves were constructed. Then, functional enrichment analyses, tumor mutation burden (TMB), tumor infiltration of immune cells, single sample Gene Set Enrichment Analysis (ssGSEA), and drug sensitivity analysis were performed. Additionally, we conducted a consensus cluster analysis to compare differences between subtypes of tumors. Finally, we validated the expression of the ERS-related lncRNAs that constructed prognostic risk score model in HNSCC tissues through quantitative real-time PCR (qRT-PCR). We developed a prognostic signature based on seven ERS-related lncRNAs, which showed better predictive performance than other clinicopathological features. The high-risk poor prognosis group had a poorer prognosis in comparison to the low-risk good prognosis. The area under the ROC curve (AUC) predicted by this model for 3-year survival rates of HNSCC patients was 0.805. Enrichment analysis revealed that the differentially expressed genes were primarily enriched in pathways related to immune responses and signal transduction. Low-risk patients had lower TMB, more immune cell infiltrations, and enhanced anti-tumor immunity. Cluster analysis indicated that cluster 3 may have a better prognosis and immunotherapy effect. In addition, the result of qRT-PCR was consistent with our analysis. This prognostic model based on seven ERS-related lncRNAs is a promising tool for risk stratification, survival prediction, and immune cell infiltration status assessment.
Sex differences in risk factors for coronary heart disease events: a prospective cohort study in Iran
Authors: Ramezankhani Azra , Azizi Fereidoun , Hadaegh Farzad 
Published: December 2023

AbstractWe investigated sex-specific associations and their differences between major cardiovascular risk factors and the risk of incident coronary heart disease (CHD) and hard CHD (defined as nonfatal myocardial infarction and CHD death). A total of 7518 (3377 men) participants from the Tehran Lipid and Glucose Study were included. Cox models were used to estimate the hazard ratios (HRs) and women-to-men ratios of HRs for CHD events associated with each risk factor. During 20 years of follow-up (1999–2018), 1068 (631 men) and 345 (238 men) new cases of CHD and hard CHD, respectively, were documented. In total population, the incidence rates per 1000 person-years were 9.5 (9.0–10.1) and 2.9 (2.6–3.2) for CHD and hard CHD, respectively. Hypertension, diabetes, pre-diabetes, and a high waist-to-hip ratio (WHR) were associated with a greater HR of hard CHD in women than men; the women-to-men HRs were 2.85 [1.36–5.98], 1.92 [1.11–3.31], 2.04 [1.09–3.80] and 1.42 [1.10–1.82], respectively. Diabetes was associated with a higher HR of CHD in women than men (ratio of HRs 1.49 (1.10–2.01). In conclusion, we found that hypertension, diabetes, pre-diabetes, and high WHR conferred a greater excess risk of CHD events in women than in men, suggesting that Iranian women may require greater attention for the prevention of CHD events.
Polystyrene nanoparticles induce concerted response of plant defense mechanisms in plant cells
Authors: Adamczyk Sylwia , Chojak-Koźniewska Joanna , Oleszczuk Sylwia , Michalski Krzysztof , Velmala Sannakajsa , Zantis Laura J. , Bosker Thijs , Zimny Janusz , Adamczyk Bartosz , Sowa Slawomir 
Published: December 2023

AbstractRecent advances in knowledge suggest that micro- and nanoplastics pose a threat to plant health, however, the responses of plants to this stressor are not well-known. Here we examined the response of plant cell defence mechanisms to nanoparticles of commonly used plastic, polystyrene. We used plant cell cultures of widely cultivated plants, the monocots wheat and barley (Triticum aestivum L., Hordeum vulgare L.) and the dicots carrot and tomato (Daucus carota L., Solanum lycopersicum L.). We measured the activities of enzymes involved in the scavenging of reactive oxygen species and nonenzymatic antioxidants and we estimated potential damages in plant cell structures and functioning via lipid peroxidation and DNA methylation levels. Our results demonstrate that the mode of action of polystyrene nanoparticles on plant cells involves oxidative stress. However, the changes in plant defence mechanisms are dependent on plant species, exposure time and nanoplastic concentrations. In general, both monocots showed similar responses to nanoplastics, but the carrot followed more the response of monocots than a second dicot, a tomato. Higher H2O2, lipid peroxidation and lower enzyme activities scavenging H2O2 suggest that tomato cells may be more susceptible to polystyrene-induced stress. In conclusion, polystyrene nanoplastics induce oxidative stress and the response of the plant defense mechanisms involving several chain reactions leading to oxidoreductive homeostasis.
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition
Authors: Kimani Serah W. , Perveen Sumera , Szewezyk Magdalena , Zeng Hong , Dong Aiping , Li Fengling , Ghiabi Pegah , Li Yanjun , Chau Irene , Arrowsmith Cheryl H. , Barsyte-Lovejoy Dalia , Santhakumar Vijayaratnam , Vedadi Masoud , Halabelian Levon 
Published: December 2023

AbstractCbl-b is a RING-type E3 ubiquitin ligase that is expressed in several immune cell lineages, where it negatively regulates the activity of immune cells. Cbl-b has specifically been identified as an attractive target for cancer immunotherapy due to its role in promoting an immunosuppressive tumor environment. A Cbl-b inhibitor, Nx-1607, is currently in phase I clinical trials for advanced solid tumor malignancies. Using a suite of biophysical and cellular assays, we confirm potent binding of C7683 (an analogue of Nx-1607) to the full-length Cbl-b and its N-terminal fragment containing the TKBD-LHR-RING domains. To further elucidate its mechanism of inhibition, we determined the co-crystal structure of Cbl-b with C7683, revealing the compound’s interaction with both the TKBD and LHR, but not the RING domain. Here, we provide structural insights into a novel mechanism of Cbl-b inhibition by a small-molecule inhibitor that locks the protein in an inactive conformation by acting as an intramolecular glue.
Arsenic is a potent co-mutagen of ultraviolet light
Authors: Speer Rachel M. , Nandi Shuvro P. , Cooper Karen L. , Zhou Xixi , Yu Hui , Guo Yan , Hudson Laurie G. , Alexandrov Ludmil B. , Liu Ke Jian 
Published: December 2023

AbstractArsenic enhances the carcinogenicity of ultraviolet radiation (UVR). However, the mechanisms of arsenic-driven oncogenesis are not well understood. Here, we utilize experimental systems to investigate the carcinogenic and mutagenic properties of co-exposure to arsenic and UVR. In vitro and in vivo exposures indicate that, by itself, arsenic is not mutagenic. However, in combination with UVR, arsenic exposure has a synergistic effect leading to an accelerated mouse skin carcinogenesis and to more than 2-fold enrichment of UVR mutational burden. Notably, mutational signature ID13, previously found only in UVR-associated human skin cancers, is observed exclusively in mouse skin tumors and cell lines jointly exposed to arsenic and UVR. This signature was not observed in any model system exposed purely to arsenic or purely to UVR, making ID13, to the best of our knowledge, the first co-exposure signature to be reported using controlled experimental conditions. Analysis of existing skin cancer genomics data reveals that only a subset of cancers harbor ID13 and these exhibit an elevated UVR mutagenesis. Our results report a unique mutational signature caused by a co-exposure to two environmental carcinogens and provide comprehensive evidence that arsenic is a potent co-mutagen and co-carcinogen of UVR.
Evidence of compensated semimetal with electronic correlations at charge neutrality of twisted double bilayer graphene
Authors: Ghosh Ayan , Chakraborty Souvik , Ghorai Unmesh , Paul Arup Kumar , Watanabe K. , Taniguchi T. , Sensarma Rajdeep , Das Anindya 
Published: December 2023

AbstractRecently, magic-angle twisted bilayer graphene (MATBLG) has emerged with various interaction-driven novel quantum phases at the commensurate fillings of the moiré superlattice, while the charge neutrality point (CNP) remains mostly a trivial insulator. Here, we show an emerging phase of compensated semimetallicity at the CNP of twisted double bilayer graphene (TDBLG), a close cousin of MATBLG, with signatures of electronic correlation. Using electrical and thermal transport, we find two orders of magnitude enhancement of the thermopower at magnetic fields much smaller than the extreme quantum limit, accompanied by large magnetoresistance ( ~ 2500%) at CNP, providing strong experimental evidence of compensated semimetallicity at CNP of TDBLG. Moreover, at low temperatures, we observe unusual sublinear temperature dependence of resistance. A recent theory1 predicts the formation of an excitonic metal near CNP, where small electron and hole pockets co-exist. We understand this sublinear temperature dependence in terms of critical fluctuations in this theory.
Metastable liquid immiscibility in the 2018–2021 Fani Maoré lavas as a mechanism for volcanic nanolite formation
Authors: Thivet Simon , Pereira Luiz , Menguy Nicolas , Médard Étienne , Verdurme Pauline , Berthod Carole , Troadec David , Hess Kai-Uwe , Dingwell Donald B. , Komorowski Jean-Christophe 
Published: December 2023

AbstractNanoscale liquid immiscibility is observed in the 2018–2021 Fani Maoré submarine lavas (Comoros archipelago). Heat transfer calculations, Raman spectroscopy, scanning and transmission electron microscopy reveal that in contrast to thin (500 µm) outer rims of homogeneous glassy lava (rapidly quenched upon eruption, >1000 °C s−1), widespread liquid immiscibility is observed in thick (1 cm) inner lava rims (moderately quenched, 1–1000 °C s−1), which exhibit a nanoscale coexistence of Si- and Al-rich vs. Ca-, Fe-, and Ti-rich melt phases. In this zone, rapid nanolite crystallization contrasts with the classical crystallization process inferred for the slower cooled ( < 1 °C s−1) lava interiors. The occurrence of such metastable liquid immiscibility at eruptive conditions controls physicochemical characteristics of nanolites and residual melt compositions. This mechanism represents a common yet frequently unobserved feature in volcanic products, with the potential for major impacts on syn-eruptive magma degassing and rheology, and thus on eruptive dynamics.
A data assimilation method to track excitation-inhibition balance change using scalp EEG
Authors: Yokoyama Hiroshi , Kitajo Keiichi 
Published: December 2023

AbstractRecent neuroscience studies have suggested that controlling the excitation and inhibition (E/I) balance is essential for maintaining normal brain function. However, while control of time-varying E/I balance is considered essential for perceptual and motor learning, an efficient method for estimating E/I balance changes has yet to be established. To tackle this issue, we propose a method to estimate E/I balance changes by applying neural-mass model-based tracking of the brain state using the Ensemble Kalman Filter. In this method, the parameters of synaptic E/I gains in the model are estimated from observed electroencephalography signals. Moreover, the index of E/I balance was defined by calculating the ratio between synaptic E/I gains based on estimated parameters. The method was validated by showing that it could estimate E/I balance changes from human electroencephalography data at the sub-second scale, indicating that it has the potential to quantify how time-varying changes in E/I balance influence changes in perceptual and motor learning. Furthermore, this method could be used to develop an E/I balance-based neurofeedback training method for clinical use.
Feasibility assessment of remanufacturing waste sheet steel into angle mesh steel
Authors: Abdullah Ziyad Tariq 
Published: December 2023

AbstractAs a better alternative to the energy‐intensive process of recycling waste sheet steel (WSS) from the exterior components of end‐of‐life vehicles to produce new steel, the feasibility of remanufacturing WSS into angle mesh steel (AMS) for construction applications is evaluated. A remanufacturing unit with a capacity of 1278 m2/day of WSS (30,000 vehicle/year) was evaluated using a triple‐bottom‐line sustainability analysis of the technological, economic, and environmental feasibilities by hybrid defuzzification–curve‐fitting, solid‐waste recoverability management, and weighting methods. Based on the remanufacturing productivity, an economic feasibility index was calculated considering the sales potential and profit, while the energy and CO2 emission savings were used to evaluate the environmental feasibility. The technical feasibility considered machine parameters and topological properties of the WSS. The Volkswagen Passat has the best remanufacturability of 200 analysed vehicle models. Remanufacturability indexes of 0.61 and 0.86 were calculated, giving remanufacturing efficiencies of 58%–82%. All feasibility indexes exceed literature thresholds, indicating that the proposed remanufacturing process is a sustainable business strategy and contributes to the United Nations Sustainability Goals of climate action; responsible consumption and production; no poverty; and industry, innovation, and infrastructure.
An extended impedance‐based fault location algorithm in power distribution system with distributed generation using synchrophasors
Authors: Chandran Sandhya , Gokaraju Ramakrishna , Narendra Krish 
Published: December 2023

AbstractAccurately locating power distribution faults reduces the total outage duration and provides better system reliability. Fault location using the traditional impedance‐based method may be very challenging in an active distribution system. However, taking into consideration the ease of implementation and cost effectiveness, a novel impedance‐based method is proposed to locate the fault by using the highly accurate time‐synchronized voltage and current phasors obtained from distribution phasor measurement units. The synchrophasor measurements obtained from the substation and various feeder segments are used in a two‐step algorithm based on the apparent impedance calculation to locate the exact source of the event. The algorithm uses phasor estimates to first identify the faulted feeder sub‐region and later uses measurements from a remote end device to eliminate pseudo‐faulted points to obtain the actual fault location. The effectiveness of the proposed method is realized using IEEE 34 bus system. Based on different fault types simulated at various parts of the system, the algorithm accurately estimates fault location in the range of ±1% of the line length. The proposed method is effective in locating faults for any type of network and topologies, with as many or as few (minimum 2) phasor measurement units in the system.
Post-colonoscopy colorectal cancers in a national fecal immunochemical test-based colorectal cancer screening program
Authors: Wisse Pieter H. A. , de Boer Sybrand Y. , Oudkerk Pool Marco , Terhaar sive Droste Jochim S , Verveer Claudia , Meijer Gerrit A. , Dekker Evelien , Spaander Manon C. W. 
Published: December 2023

Abstract
Background Post-colonoscopy colorectal cancers (PCCRCs) decrease the effect of colorectal cancer (CRC) screening programs. To enable PCCRC incidence reduction in the long-term, we classified PCCRCs diagnosed after colonoscopies performed in a fecal immunochemical test (FIT)-based screening program.
Methods PCCRCs diagnosed after colonoscopies performed between 2014–2016 for a positive FIT in the Dutch CRC screening program were included. PCCRCs were categorized according to the World Endoscopy Organization consensus statement into (a) interval PCCRC (diagnosed before the recommended surveillance); (b) non-interval type A (diagnosed at the recommended surveillance interval); (c) non-interval type B (diagnosed after the recommended surveillance interval); or (d) non-interval type C (diagnosed after the intended recommended surveillance interval, with surveillance not implemented owing to co-morbidity). The most probable etiology was determined by root-cause analysis. Tumor stage distributions were compared between categories.
Results 116362 colonoscopies were performed after a positive FIT with 9978 screen-detected CRCs. During follow-up, 432 PCCRCs were diagnosed. The 3-year PCCRC rate was 2.7%. PCCRCs were categorized as interval (53.5%), non-interval type A (14.6%), non-interval type B (30.6%), and non-interval type C (1.4%). The most common etiology for interval PCCRCs was possible missed lesion with adequate examination (73.6%); they were more often diagnosed at an advanced stage (stage III/IV; 53.2%) compared with non-interval type A (15.9%; P<0.001) and non-interval type B (40.9%; P=0.03) PCCRCs.
Conclusions The 3-year PCCRC rate was low in this FIT-based CRC screening program. Approximately half of PCCRCs were interval PCCRCs. These were mostly caused by missed lesions and were diagnosed at a more advanced stage. This emphasizes the importance of high quality colonoscopy with optimal polyp detection.
Predicting Morphological Changes to Vessel Walls Adjacent to Unruptured Cerebral Aneurysms Using Computational Fluid Dynamics
Authors: Sasaki Kento , Komatsu Fuminari , Miyatani Kyosuke , Tanaka Riki , Yamada Yasuhiro , Kato Yoko , Hirose Yuichi 
Published: December 2023

Abstract
Objective This study compared intraoperative findings with preoperative computed tomography angiography (CTA) and computational fluid dynamics (CFD) analysis of perianeurysmal findings for the indication of possible vessel wall thinning.
Materials and Methods Participants comprised 38 patients with unruptured middle cerebral artery aneurysms treated by surgical clipping at our hospital between May 2020 and April 2021. We defined parent artery radiation sign (PARS) as the presence of each of the following three findings in CFD analysis based on preoperative CTA: (1) impingement of the stream line on the outer parent vessel wall of the aneurysm; (2) radiation of wall shear stress vectors outwards from the same site; and (3) increased wall pressure compared with the surrounding area. CFD analysis showing PARS was compared with intraoperative findings.
Results In all nine cases with PARS, no morphological abnormalities were found in the same area on CTA. However, intraoperative findings showed thinning of the parent artery wall in one of the nine cases and formation of a very small mass in three cases, differing from CTA findings. All nine patients underwent additional clipping and/or wrapping and coating at the site of PARS.
Conclusion Detecting thinning of the vessel wall or the presence of a microaneurysm may be difficult in endovascular therapy, which is based on the visualization of the vessel lumen. CFD analysis suggests the necessity of confirming findings for the vessel wall around an aneurysm by direct manipulation, as the presence of PARS may indicate partial thinning of the vessel wall or formation of a microaneurysm.
Hand Radiographs in Skeletal Dysplasia: A Pictorial Review
Authors: S. Dheeksha D. , Chandola Stuti , Jain Aayush , Gupta Neerja , Kabra Madhulika , Jana Manisha 
Published: December 2023

AbstractSkeletal dysplasias or osteochondrodysplasias comprise a large heterogeneous group of genetic disorders and possess significant overlap on imaging, which adds to the dilemma of the reporting radiologist. These entities are routinely evaluated with a detailed skeletal survey and hand radiographs form a crucial part of a complete survey. Certain conditions have characteristic imaging findings that enable a diagnosis be made on hand radiograph alone. Additionally, hand radiographs may also demonstrate findings that may be suggestive of a particular diagnosis/differential diagnoses and would warrant further assessment for proving the same. We aim to demonstrate the use of hand radiographs in diagnosis of various such entities through this review. Although they cannot replace a complete skeletal survey in the diagnosis, hand radiographs performed for other indications might alert a radiologist to the diagnosis of an unsuspected skeletal dysplasia.
Transjugular Intrahepatic Portosystemic Shunt (TIPS) Extension for Transhepatic Mesocaval Shunt Creation: A Case Series for Treating Refractory Upper Gastrointestinal Bleeding in Patients with Chronic Portal Vein Thrombosis
Authors: Patidar Yashwant , Babbar Sushant , Mukund Amar , Sarin Shiv Kumar 
Published: December 2023

AbstractTransjugular intrahepatic portosystemic shunt (TIPS) is known to benefit patients with decompensated liver disease by alleviating portal pressure. However, TIPS creation is technically difficult and challenging to perform in patients with chronic portal vein thrombosis (PVT) (4,5). Multiple endovascular techniques for portal vein recanalization with or without creating portosystemic shunt are available to decompress and alleviate portal hypertension in patients with PVT. In this case series, we represent TIPS extension to create an endovascular mesocaval shunt for the treatment of refractory upper gastrointestinal bleeding.
Impact of the 2023 FIGO Staging System for Endometrial Cancer on the Use of Imaging Services: An Indian Perspective
Authors: Chandramohan Anuradha , Manchanda Smitha , Renganathan Rupa , Popat Palak Bhavesh , Shah Diva , Dhamija Ekta , Sen Anitha 
Published: December 2023

AbstractThe new 2023 update of the International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer incorporates the advances made in the understanding of the pathology and molecular classifications into the staging system. While the new staging system aids in precision medicine and may lead to better documentation of prognostic risk categories of endometrial cancer, it is complex and calls for an integrated approach and better communication between multiple disciplines involved in the management of endometrial cancer. In this review article, we address how the referral patterns to imaging services might change considering the updated staging system for endometrial cancer. We also discuss the practical aspects and nuances involved in the radiology service delivery and reporting practices as we adopt the new FIGO staging system for managing endometrial cancer patients.