bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between Diet Quality Index–International score and risk of diminished ovarian reserve: a case–control study
Authors: Ziaei Rahele , Ghasemi-Tehrani Hatav , Movahedi Minoo , Kalatehjari Maryam , Vajdi Mahdi , Mokari-Yamchi Amin , Elyasi Mahshid , Ghavami Abed 
Published: November 2023

IntroductionAlthough limited evidence exists on the beneficial reproductive effects of diet quality indices, the association is still largely unknown. We aimed to investigate the association between Diet Quality Index-International (DQI-I) and antral follicle count (AFC) and serum antimullerian hormone (AMH) as precise and sensitive markers of ovarian reserve and to assess the risk of diminished ovarian reserve (DOR) in women seeking fertility treatments.MethodsIn a case-control study, 370 women (120 women with DOR and 250 women with normal ovarian reserve as controls), matched by age and body mass index (BMI), were recruited. Dietary intake was obtained using a validated 80-item semi-quantitative food frequency questionnaire (FFQ). The quality of diets was assessed using DQI-I, which included four major dietary components: variety (0–20 points), adequacy (0–40 points), moderation (0–30 points), and overall balance (0–10 points). DQI-I score was categorized by quartiles based on the distribution of controls. AFC, serum AMH and anthropometric indices were measured. Logistic regression models were used to estimate multivariable odds ratio (OR) of DOR across quartiles of DQI-I score.ResultsIncreased adherence to DQI-I was associated with higher AFC in women with DOR. After adjusting for potential confounders, the odds of DOR decreased with increasing DQI-I score (0.39; 95% CI: 0.18–0.86).ConclusionGreater adherence to DQI-I, as a food and nutrient-based quality index, may decrease the risk of DOR and improve the ovarian reserve in women already diagnosed with DOR. Our findings, though, need to be verified through prospective studies and clinical trials.
Global research trends of the application of artificial intelligence in bladder cancer since the 21st century: a bibliometric analysis
Authors: Zhou Yingjian , Xu Wenchao , Zeng Yan , Li Hao , Liu Zhuo , Wang Tao , Liu Jihong , Jiang Hongyang 
Published: November 2023

IntroductionSince the significant breakthroughs in artificial intelligence (AI) algorithms, the application of AI in bladder cancer has rapidly expanded. AI can be used in all aspects of the bladder cancer field, including diagnosis, treatment and prognosis prediction. Nowadays, these technologies have an excellent medical auxiliary effect and are in explosive development, which has aroused the intense interest of researchers. This study will provide an in-depth analysis using bibliometric analysis to explore the trends in this field.MethodDocuments regarding the application of AI in bladder cancer from 2000 to 2022 were searched and extracted from the Web of Science Core Collection. These publications were analyzed by bibliometric analysis software (CiteSpace, Vosviewer) to visualize the relationship between countries/regions, institutions, journals, authors, references, keywords.ResultsWe analyzed a total of 2368 publications. Since 2016, the number of publications in the field of AI in bladder cancer has increased rapidly and reached a breathtaking annual growth rate of 43.98% in 2019. The U.S. has the largest research scale, the highest study level and the most significant financial support. The University of North Carolina is the institution with the highest level of research. EUROPEAN UROLOGY is the most influential journal with an impact factor of 24.267 and a total citation of 11,848. Wiklund P. has the highest number of publications, and Menon M. has the highest number of total citations. We also find hot research topics within the area through references and keywords analysis, which include two main parts: AI models for the diagnosis and prediction of bladder cancer and novel robotic-assisted surgery for bladder cancer radicalization and urinary diversion.ConclusionAI application in bladder cancer is widely studied worldwide and has shown an explosive growth trend since the 21st century. AI-based diagnostic and predictive models will be the next protagonists in this field. Meanwhile, the robot-assisted surgery is still a hot topic and it is worth exploring the application of AI in it. The advancement and application of algorithms will be a massive driving force in this field.
Surgical oncological emergencies in octogenarian patients
Authors: Friziero Alberto , Sperti Cosimo , Riccio Federica , Zuin Irene Sole , Vallese Lorenzo , Serafini Simone , Amico Alessandra , Valli Valeria , Da Re Chiara , Baldan Nicola , Valmasoni Michele , Da Dalt Gianfranco 
Published: November 2023

BackgroundSurgical oncological emergencies represent a frequent challenge in acute settings, with postoperative courses characterized by high morbidity and mortality. An accurate selection of patients who could benefit from surgery is essential to avoid unnecessary invasive treatment. In this study, we tried to determine if advanced age (&gt;80 years) represents a risk factor for negative short-term outcome in patients undergoing emergency surgery for acute abdominal oncological illness.MethodsWe retrospectively analyzed the records of patients who underwent emergency oncological surgery at the Department of Acute Care Surgery of Padua General Hospital from January 2018 to December 2022. One hundred two cancer patients were included in the study. Among them, 42 were aged ≥80 years (41%). Multiple preoperative and postoperative parameters were recorded, and the follow-up period was at least 90 days. Multivariate logistic regression analyses were used to identify factors associated with short-term postoperative outcomes.ResultsIn the octogenarian group, 30-day mortality was 11% vs. 9.5% in the younger group [p = not significant (ns)] and 90-day mortality was 17.6% in the octogenarian group vs. 20.5% in the younger group (p = ns). Postoperative morbidity and hospital length of stay were not significantly different in the two groups. Low albumin levels [odds ratio (OR) 30.6, 9.51–87.07] and elevated lactate dehydrogenase (LDH) levels (OR 26.4, 9.18–75.83) were predictive for short-term mortality in surgical oncological emergencies.ConclusionAdvanced age is not a risk factor for negative outcomes in surgical oncological emergencies. Therefore, surgical options should be considered in octogenarians with oncological emergencies and acceptable clinical conditions. Serum albumin levels and LDH can help predict the postoperative outcome after surgery for oncological emergencies.
First operation of the JUNGFRAU detector in 16-memory cell mode at European XFEL
Authors: Sikorski Marcin , Ramilli Marco , de Wijn Raphael , Hinger Viktoria , Mozzanica Aldo , Schmitt Bernd , Han Huijong , Bean Richard , Bielecki Johan , Bortel Gábor , Dietze Thomas , Faigel Gyula , Kharitonov Konstantin , Kim Chan , Koliyadu Jayanath C. P. , Koua Faisal H. M. , Letrun Romain , Lopez Luis M. , Reimers Nadja , Round Adam , Sarma Abhisakh , Sato Tokushi , Tegze Miklós , Turcato Monica 
Published: November 2023

The JUNGFRAU detector is a well-established hybrid pixel detector developed at the Paul Scherrer Institut (PSI) designed for free-electron laser (FEL) applications. JUNGFRAU features a charge-integrating dynamic gain switching architecture, with three different gain stages and 75 μm pixel pitch. It is widely used at the European X-ray Free-Electron Laser (EuXFEL), a facility which produces high brilliance X-ray pulses at MHz repetition rate in the form of bursts repeating at 10 Hz. In nominal configuration, the detector utilizes only a single memory cell and supports data acquisition up to 2 kHz. This constrains the operation of the detector to a 10 Hz frame rate when combined with the pulsed train structure of the EuXFEL. When configured in so-called burst mode, the JUNGFRAU detector can acquire a series of images into sixteen memory cells at a maximum rate of around 150 kHz. This acquisition scheme is better suited for the time structure of the X-rays as well as the pump laser pulses at the EuXFEL. To ensure confidence in the use of the burst mode at EuXFEL, a wide range of measurements have been performed to characterize the detector, especially to validate the detector alibration procedures. In particular, by analyzing the detector response to varying photon intensity (so called ‘intensity scan’), special attention was given to the characterization of the transitions between gain stages. The detector was operated in both dynamic gain switching and fixed gain modes. Results of these measurements indicate difficulties in the characterization of the detector dynamic gain switching response while operated in burst mode, while no major issues have been found with fixed gain operation. Based on this outcome, fixed gain operation mode with all the memory cells was used during two experiments at EuXFEL, namely in serial femtosecond protein crystallography and Kossel lines measurements. The positive outcome of these two experiments validates the good results previously obtained, and opens the possibility for a wider usage of the detector in burst operation mode, although compromises are needed on the dynamic range.
Asymmetric and symmetric dimethylarginine in high altitude pulmonary hypertension (HAPH) and high altitude pulmonary edema (HAPE)
Authors: Hannemann Juliane , Freytag Julius , Schiefer Lisa Maria , Macholz Franziska , Sareban Mahdi , Schmidt-Hutten Lena , Stang Heike , Schwedhelm Edzard , Swenson Erik R. , Böger Rainer , Berger Marc Moritz 
Published: November 2023

Introduction: High altitude exposure may lead to high altitude pulmonary hypertension (HAPH) and high altitude pulmonary edema (HAPE). The pathophysiologic processes of both entities have been linked to decreased nitric oxide (NO) availability.Methods: We studied the effect of acute high altitude exposure on the plasma concentrations of asymmetric (ADMA) and symmetric dimethylarginine (SDMA), L-arginine, L-ornithine, and L-citrulline in two independent studies. We further investigated whether these biomarkers involved in NO metabolism were related to HAPH and HAPE, respectively. Fifty (study A) and thirteen (study B) non-acclimatized lowlanders were exposed to 4,559 m for 44 and 67 h, respectively. In contrast to study A, the participants in study B were characterized by a history of at least one episode of HAPE. Arterial blood gases and biomarker concentrations in venous plasma were assessed at low altitude (baseline) and repeatedly at high altitude. HAPE was diagnosed by chest radiography, and HAPH by measuring right ventricular to atrial pressure gradient (RVPG) with transthoracic echocardiography. AMS was evaluated with the Lake Louise Score (LLS) and the AMS-C score.Results: In both studies SDMA concentration significantly increased at high altitude. ADMA baseline concentrations were higher in individuals with HAPE susceptibility (study B) compared to those without (study A). However, upon high altitude exposure ADMA only increased in individuals without HAPE susceptibility, while there was no further increase in those with HAPE susceptibility. We observed an acute and transient decrease of L-ornithine and a more delayed but prolonged reduction of L-citrulline during high altitude exposure. In both studies SDMA positively correlated and L-ornithine negatively correlated with RVPG. ADMA was significantly associated with the occurrence of HAPE (study B). ADMA and SDMA were inversely correlated with alveolar PO2, while L-ornithine was inversely correlated with blood oxygenation and haemoglobin levels, respectively.Discussion: In non-acclimatized individuals ADMA and SDMA, two biomarkers decreasing endothelial NO production, increased after acute exposure to 4,559 m. The observed biomarker changes suggest that both NO synthesis and arginase pathways are involved in the pathophysiology of HAPH and HAPE.
Mobile social media use and life satisfaction among adolescents: a moderated mediation model
Authors: Meng Sujie , Kong Fanchang , Dong Wanghao , Zhang Ying , Yu Tingting , Jin Xiangdong 
Published: November 2023

IntroductionAdolescence is a sensitive transitional period accompanied by great physical, mental, and behavioral changes. Therefore, maintaining physical and mental health is crucial to the growth and development of adolescents. As one of the important indicators of mental health, the influencing factors of life satisfaction have been widely concerned by scholars. In recent years, with the rapid development of Internet technology, mobile social media has penetrated into all aspects of adolescents’ life, which has a subtle impact on their physical and mental health. Existing studies have indicated that mobile social media use can affect adolescents’ life satisfaction. However, little is known about the mediating and moderating mechanisms linking this association. This study developed a moderated mediation model to examine the mediating role of meaning in life and the moderating role of childhood psychological maltreatment.MethodsA total of 1,198 adolescents across four provinces and municipalities of China completed questionnaires on mobile social media use, life satisfaction, meaning in life, and childhood psychological maltreatment.ResultsAfter controlling for gender and age, the results demonstrated that mobile social media use was positively associated with life satisfaction and meaning in life among adolescents. Moreover, meaning in life fully mediated the association between mobile social media use and life satisfaction. Finally, the association between mobile social media use and life satisfaction, as well as that between mobile social media use and meaning in life, was moderated by childhood psychological maltreatment. Specifically, these associations are stronger for adolescents with high levels of psychological maltreatment.DiscussionThese findings shed light on the important mechanism underlying mobile social media use’s effects on adolescents’ life satisfaction, which is helpful to formulate targeted measures for improving adolescents’ life satisfaction.
Assessing pandemic preparedness, response, and lessons learned from the COVID-19 pandemic in four south American countries: agenda for the future
Authors: Ramírez Varela Andrea , Touchton Michael , Miranda J. Jaime , Grueso Juliana Mejía , Laajaj Rachid , Carrasquilla Gabriel , Florez Martha Vives , Gaviria Ana María Vesga , Hoyos Ana María Ortiz , Duarte Esteban Orlando Vanegas , Morales Alejandra Velásquez , Velasco Nubia , Restrepo Silvia Restrepo 
Published: November 2023

IntroductionThe COVID-19 pandemic emerged in a context that lacked adequate prevention, preparedness, and response (PPR) activities, and global, regional, and national leadership. South American countries were among world’s hardest hit by the pandemic, accounting for 10.1% of total cases and 20.1% of global deaths.MethodsThis study explores how pandemic PPR were affected by political, socioeconomic, and health system contexts as well as how PPR may have shaped pandemic outcomes in Argentina, Brazil, Colombia, and Peru. We then identify lessons learned and advance an agenda for improving PPR capacity at regional and national levels. We do this through a mixed-methods sequential explanatory study in four South American countries based on structured interviews and focus groups with elite policy makers.ResultsThe results of our study demonstrate that structural and contextual barriers limited PPR activities at political, social, and economic levels in each country, as well as through the structure of the health care system. Respondents believe that top-level government officials had insufficient political will for prioritizing pandemic PPR and post-COVID-19 recovery programs within their countries’ health agendas.DiscussionWe recommend a regional COVID-19 task force, post-pandemic recovery, social and economic protection for vulnerable groups, improved primary health care and surveillance systems, risk communication strategies, and community engagement to place pandemic PPR on Argentina, Brazil, Colombia, and Peru and other South American countries’ national public health agendas.
The mediation effect of social support between stigma and social alienation in patients with stroke
Authors: Wu Yu , Yan Zeping , Fornah Lovel , Zhao Jun , Wu Shicai 
Published: November 2023

BackgroundSocial alienation is prevalent and causes adverse outcomes in stroke. Previous studies have linked stigma with social alienation. However, little is known about the mechanisms behind this relationship. This study explored the mediation effects of social support between stigma and social alienation.MethodsA cross-sectional design was used to study 248 patients with stroke admitted to a tertiary rehabilitation hospital in Beijing, China, from December 2022 to July 2023. Patients were assessed using a general information questionnaire, the Stroke Stigma Scale, the Social Support Rating Scale, and the Generalized Social Alienation Scale. The PROCESS macro in SPSS was used to examine the mediation model.ResultsThe results showed that stigma has a negative effect on social support (β = −0.503, p&lt;0.001); stigma has a positive effect on social alienation (β = 0.768, p&lt;0.001). Social support mediated the relationship between stigma and social alienation, with a mediation effect of 0.131 (95%CI: 0.060, 0.214), and indirect effects accounted for 17.06% of the total effect.ConclusionSocial support mediated the relationship between stigma and social alienation. These findings suggest that intervention targeting the enhancement of social support may prevent or reduce social alienation among patients with stroke.
Analysis of anthropometric and physical performance variables in U-17 soccer players
Authors: Honório Samuel , Batista Marco , Serrano João , Petrica João , Rebelo Miguel , Vieira Fernando , Lopes André , Santos Jorge 
Published: November 2023

IntroductionSoccer is considered a multifaceted collective sport, and to reach an elevated level, players must have moderate to high power, good agility, joint flexibility and muscle development. Also, players must be able to generate high torques during fast movements, which implies the development of different capacities, understood as multifactorial preparation. The objective was to analyse the effects of training (aerobic and continuous) on the leg power, fatigue levels, speed, agility, body fat, muscle mass and bone mass of these players.MethodsSeventy-two soccer players, male and under 17, from 4 teams participated. The teams performed 3 times a week training sessions of about 60–90 min each. Informed consent requests were given to their parents for authorisation to participate in this investigation. Data was collected in two different time points, about ten months apart. Specific tests were performed for each variable: the vertical jump with Bosco System for leg power, the T-Test for agility, the linear sprint test for speed and the RAST test for fatigue levels. A precision Tanita scale was used for the anthropometric tests such as body fat, muscle mass and bone mass. Statistical procedures were applied through the Wilcoxon test to compare the two time points of evaluation.ResultsImprovements were found between evaluations regarding the level of anthropometric and physical fitness variables.ConclusionsThe implemented training improved all the analysed variables with significant statistical values for leg power, speed, bone mass, muscle mass and fat mass.
Using ultrasonography for verifying feeding tube placements in cats
Authors: Bruno Barbara , Savarino Paolo , Zanatta Renato , Rallo Silvia , De Giovanni Andrea , Maurella Cristiana , Borrelli Antonio 
Published: November 2023

IntroductionThis study aimed to investigate the use of ultrasonography for verifying feeding tube placement in hospitalized cats compared with radiographic evaluation.MethodsThis prospective investigation was performed on client-owned cats. The position of the feeding tube was checked using right lateral thoracic radiography and ultrasonography. Ultrasound examinations were performed using a high-frequency linear transducer and a microconvex transducer. The examination was performed in three steps: transverse and longitudinal planes of the left side of the animal’s neck to identify the feeding tube in the esophagus, and a longitudinal angled plane of the epigastrium to identify the tube at the lower esophageal sphincter.ResultsA total of 25 cats were included in this study. Assessing the correct positioning of the feeding tubes using a right lateral thoracic radiograph revealed that the tube was in the distal esophagus in 12/25 cats and reached the stomach in 13/25 cases.DiscussionIn all cats, both ultrasonography and right lateral chest radiography identified the feeding tube at the esophageal level. For stomach, ultrasonography demonstrated good values of diagnostic performance compared to radiography, with excellent reliability and validity in terms of sensitivity and predictive value. Ultrasonography is a valid tool for confirming tube placement in the esophagus and is almost as efficient as radiology.
Evaluation of Fungicides as Protective and Curative Treatments against Canker Disease of Eucalyptus urograndis Caused by Chrysoporthe deuterocubensis in Malaysia
Authors: Ambrose Annya , Peter Remun Attlee Banyang , Shamsul Kamar Nura Adilla , Mohamad Pazi Ahmad Mustapha , Wan Azhar Wan Muhammad Azrul , Awing Norida Hanim , Liam Jack , Terhem Razak 
Published: November 2023

Over the years, Eucalyptus plantations have rapidly expanded in Sarawak, Malaysia, accounting for 19% of the total forest plantation area. In a routine forest health surveillance conducted in 2022 at Sarawak, Malaysia, tree stands of Eucalyptus urograndis (Eucalyptus grandis × Eucalyptus urophylla hybrid) were detected with symptoms of stem canker disease caused by Chrysoporthe infection. Given the limited information on the chemical control of Chrysoporthe stem canker disease, there is a growing need to develop effective chemical control strategies to protect and cure Chrysoporthe infection on E. urograndis trees. Therefore, this study aimed to identify the causal pathogen of this stem canker disease in 7-year-old E. urograndis trees in Sarawak, Malaysia, and evaluate the efficacy of various fungicides as curative or protectant treatments on canker infection using artificial inoculation methods. Fungal isolates were first collected and subjected to molecular identification and pathogenicity analysis. Then, in vitro efficacy tests were evaluated using five licensed fungicides: thiram, prochloraz manganese chloride, copper hydroxide, dimethomorph, and mancozeb. Subsequently, the performance of these fungicides was assessed through preventive and curative field experiments on 10-year-old E. urograndis trees using the artificial inoculation technique. Based on the morphological and phylogenetic analysis of the ITS1/ITS4, β-tubulin 2 (BT2), and the combined ITS1/ITS4 and BT2 sequences extracted from 20 fungal isolates, Chrysoporthe deuterocubensis was identified as the causal pathogen of the canker disease, with isolate CHRY18 recording the highest virulence. The in vitro efficacy tests showed that prochloraz manganese chloride achieved 100% inhibition against C. deuterocubensis at 1.0 mg/mL. In the preventive experiment, thiram significantly inhibited C. deuterocubensis infection, yielding the shortest lesion length (19.40 mm) compared to the non-treated control (47.48 mm) at 20 weeks post-inoculation. In the curative experiment, a significant reduction of 54.7% in lesion length was observed in inoculated symptomatic trees after 20 weeks of post-fungicide treatment with copper hydroxide. In conclusion, this study demonstrated prochloraz manganese chloride, thiram, and copper hydroxide as effective chemical controls of C. deuterocubensis stem canker on E. urograndis.