bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Cardiac Troponin T May Be a Marker of Worsening Skeletal Myopathy in Inclusion Body Myositis
Authors: Fu Zhiqing , Zhang Xiujin 
Published: January 2025

Abstract
Previous studies have reported elevated cardiac troponin T (cTnT) in patients with inclusion body myositis due to skeletal myopathy. Although the trends of cTnT have been reported in some cases, the onset of elevation has barely been reported. In this case, elevated cTnT in a patient diagnosed with inclusion body myositis is discussed. The routine laboratory tests of a 68-year-old male patient showed a positive cTnT test. Eight months later, he developed symptoms of myasthenia gravis. Subsequently, after a series of examinations, the patient was diagnosed with inclusion body myositis. Despite a transient decrease in cTnT levels following intravenous immunoglobulin treatment, the levels rapidly rebounded and continued to rise, suggesting continued progression of skeletal muscle damage in inclusion body myositis. It was concluded that the elevated cTnT was due to re-expression of cTnT in the damaged skeletal muscles of inclusion body myositis. This suggests that dynamic monitoring of cTnT levels in inclusion body myositis patients may predict the progression of myositis and promote timely treatment.
Comparison of 2-Bag Method With Serial Bag Method for Treatment of Pediatric Diabetic Ketoacidosis
Authors: Hone Kristina , Agus Michael S. D. , Russ Christiana M. , Manzi Shannon , Berbert Laura , Engstrand Shannon , Reed Mary Poyner 
Published: January 2025

Background
There have been 2 primary methods of intravenous fluid administration for diabetic ketoacidosis (DKA) treatment described in the literature: the serial bag method and the 2-bag method.

Objectives
This study will assess the clinical outcomes and workflow efficiency after a transition in practice from the serial fluid method to the 2-bag method for pediatric DKA.

Methods
This was a retrospective chart review of pediatric DKA patients 18 years or younger, 1 year before and after the transition was conducted. After exclusion criteria, 94 patients in the serial bag method group and 100 patients in the 2-bag method group remained. Variables included patient demographics, laboratory values, and duration of therapy.

Results
Patients achieving physiologic resolution of DKA had a median duration of 8.7 hours using the serial bag method and 7.5 hours using the 2-bag method (P = .193). Duration of DKA pharmacologic therapy had median values of 11.6 and 12.7 hours, between the serial bag and 2-bag method, respectively (P = .203). The 2-bag method resulted in faster workflow efficiency per bag for intravenous fluids, with a median duration of 35.5 minutes compared with 44.5 minutes using the serial bag (P = .025). Episodes of hypokalemia (P = .010) and hyperchloremia (P = .002) with the 2-bag method were significantly more frequent.

Discussion
Duration of DKA pharmacologic therapy and that of physiologic DKA were not statistically different between methods. Workflow efficiency improved with the 2-bag method. Further studies are needed to address potential electrolyte disturbances with the 2-bag method.
Prevalence and predictors of genitourinary syndrome of menopause: a population-based study in middle-aged Brazilian women
Authors: Bevilacqua Mariana Rosa Ribeiro , Costa-Paiva Lucia , Pedro Adriana Orcesi 
Published: January 2025

Abstract

Objective
This study aimed to determine the prevalence and predictors of genitourinary syndrome of menopause (GSM) in Brazilian women.

Methods
A cross-sectional population-based household survey was conducted among 749 women aged 45 to 60 years. The dependent variable was the presence of GSM, which was assessed using a pretested structured questionnaire. The independent variables included sociodemographic data, health-related habits and morbidities, self-perception of health, and gynecological background.

Results
The mean age of the participants was 52.5 ± 4.4 years, and the mean age of menopause was 46.4 ± 6.2 years. GSM was prevalent in 51.4% of the women. The most prevalent symptoms were dyspareunia (35%), daily vaginal dryness (25.1%), and intercourse vaginal dryness (24%). Poisson regression analysis demonstrated that global GSM was associated with having a partner, topical estrogen treatment (TET), depression/anxiety, and rheumatological diseases. The genital symptoms of GSM were related to peri/postmenopausal status, TET, multimorbidity, sexual activity, and the absence of vaginal birth. Factors associated with GSM urinary symptoms were negative self-perception of health, having at least one vaginal birth, depression/anxiety, and rheumatological diseases. Sexual symptoms were associated with having a partner, using TET, depression/anxiety, and rheumatic disease. GSM affected the lives of 42.8% of the women to some degree, and 43% discussed their symptoms with their gynecologists.

Conclusions
GSM was prevalent in half of the women in this study, and several factors were associated with its presence. These results highlight the compelling need to understand these factors, improve diagnoses, and increase access to treatment.
The complementary effects of formal and informal budgetary performance feedback on doctor-managers' responsibilities
Authors: Paolini Manuela , Raucci Domenico , Morandi Federica , Di Vincenzo Fausto 
Published: January 2025

Background
The reforms that have affected public health care organizations have changed the tasks and responsibilities of physicians heading operational units, who have become doctor-managers. This hybridization makes doctor-managers vulnerable to role ambiguities, with possible dysfunctional effects on their managerial behaviors and performance. The enhancement of different sources of budgetary performance feedback (BPF) and perceived organizational support (POS) can help them reconcile their managerial and clinical professional domains.

Purpose
Rooted in psychology-based budgeting research, this study aimed to show the role of doctor-managers' perceptions of BPF by examining the complementary effects of formal and informal BPF on POS and their satisfaction with the budget-holder role.

Methodology/Approach
We collected self-reported data by administering questionnaires to a sample of doctor-managers from Italian public health care organizations. The hypotheses were tested using a linear regression model, clustered at the hospital level. Mediation analysis was used to test the mediating effects of POS.

Results
Findings showed that formal and informal BPF perceptions positively influenced POS and satisfaction with the budget-holder role. Further, POS mediated the BPF–role satisfaction link.

Conclusion
The study adds to the limited research on the individual-level benefits of perceived formal and informal BPF as complementary mechanisms for improving doctor-managers' attitudes toward the budget-holder role.

Practice Implications
Top management and controllers should develop budgeting practices that consider the psychological factors related to the complementary functioning of formal and informal BPFs. These factors may support doctor-managers in meeting their responsibilities as budget holders and mitigate role ambiguities.
Dissatisfaction after implantation of extended depth-of-focus intraocular lenses
Authors: Wanten Joukje C. , Bauer Noël J.C. , Berendschot Tos T.J.M. , van den Biggelaar Frank J.H.M. , Nuijts Rudy M.M.A. 
Published: January 2025

Purpose:
To evaluate the symptoms, etiology and treatment of patient dissatisfaction after extended depth-of-focus (EDOF) intraocular lens (IOL) implantation.

Setting:
University Eye Clinic, Maastricht University Medical Center, the Netherlands

Design:
Retrospective case series.

Methods:
For this study, all medical records of patients who received an EDOF IOL from July 2020 to July 2022 were reviewed. Patients were included if they had reported any dissatisfaction after surgery. The main outcome parameters were reasons for dissatisfaction (subjective complaints) and the presumed etiology of the complaints.

Results:
Out of 202 patients (354 eyes) who underwent EDOF IOL implantation, 83 eyes (22.8%) of 52 dissatisfied patients were included. Blurred vision was the predominant complaint, reported in 78 eyes (94%). Photic phenomena were reported in 21 eyes (25.3%), with 16 eyes (76.2%) experiencing coexisting blurred vision. The major etiologies for dissatisfaction in this cohort were residual ametropia (51.8%), dry eye disease (26.5%), and posterior capsular opacification (12.0%). Treatments were administered to 85.5% of the eyes, including interventions such as artificial tears, spectacles, or refractive surgery enhancement. A small number of patients (n=12; 5.9%) remained dissatisfied despite intervention.

Conclusion:
Based on this real-world data study, dissatisfaction following EDOF IOL implantation can be effectively identified and treated in most cases.
Symptoms in Persons With Either Active or Inactive Crohn‘s Disease Are Agnostic to Disease Phenotype
Authors: Bernstein Charles N. , Nugent Zoann , Panaccione Remo , Marshall Deborah A. , Kaplan Gilaad G. , Dieleman Levinus A. , Vanner Stephen , Graff Lesley A. , Otley Anthony , Jones Jennifer , Buresi Michelle , Murthy Sanjay , Borgaonkar Mark , Bressler Brian , Bitton Alain , Croitoru Kenneth , Sidani Sacha , Fernandes Aida , Moayyedi Paul 
Published: January 2025

Background:
We aimed to examine the relationship between disease symptoms and disease phenotype in a large Canadian cohort of persons with Crohn’s disease (CD).

Methods:
Adults (n=1515) with CD from 14 Canadian centers participated in the Mind And Gut Interactions Cohort (MAGIC) between 2018 and 2023. Disease activity was measured using the 24-item IBD Symptom Inventory-Short-Form (IBDSI-SF). We compared the symptoms commonly associated with active versus inactive disease, and explored symptoms patterns in relation to disease phenotype, based on the Montreal Classification. To assess psychological status the Generalized Anxiety Disorder-7 and Patient Health Questionnaire-9 were used.

Results:
The mean disease duration was 15.6±11.8 years. The 5 most common symptoms were similar for those with active disease, although at higher prevalence (89% to 98%) versus those with inactive disease (47% to 79%), and included fatigue, diarrhea, gas, bloating, and urgency. The intensity of symptoms was higher in those with active than inactive IBDSI-SF scores. The rank order and relative distribution of the symptoms and intensity of the symptoms reported were similar between those with different disease phenotypes B1, B2, and B3 and L1, L2, and L3. Persons with active IBDSI-SF had a higher prevalence of anxiety (24.6%) and depression (38.2%) versus persons with inactive IBDSI-SF (6.3% and 8%, respectively)

Conclusions:
Individuals with CD with active and inactive disease by IBDSI, experience similar symptoms, but the prevalence of symptoms and their intensity is greater in persons with active IBDSI. Persons with inactive IBDSI report many symptoms. There was no difference in symptom reporting by disease behavior or location.
Association between socioeconomic status and nonurgent presentations to pediatric emergency departments: a retrospective study
Authors: Mancheron Alexandre , Vincent-Cassy Christophe , Guedj Romain , Chappuy Hélène , De Groc Thibault , Duval Arnould Marc , Gajdos Vincent , Galerne Aurélien , Soussan-Banini Valérie , Titomanlio Luigi , Michel Morgane , Aupiais Camille 
Published: January 2025

Background and importance
Access to healthcare remains a persistent challenge. Socially disadvantaged populations often encounter barriers to care and may frequently seek out emergency departments (EDs), including for nonurgent medical care.

Objective
The objective of this study is to study the association between nonurgent presentations to pediatric EDs and patients’ socioeconomic environment in an urban setting.

Design, setting, and participants
A retrospective study of all visits to a pediatric ED in eight participating centers of the Paris metropolitan area (France) between 1 January 2017 and 31 December 2021 was carried out. Routinely collected data were analyzed.

Exposure
Socioeconomic status was evaluated using ecological variables defined at the municipality level. These variables were collected from public sources and included a social deprivation index, the accessibility to general practitioners, the proportion of single-parent families, and the proportion of immigrants.

Outcome measure and analysis
The primary endpoint was a nonurgent ED presentation, defined as being assigned one of the two lowest triage categories on a five-point scale. A multilevel logistic model assessed the association between nonurgent ED presentations and patients’ characteristics, socioeconomic environment, and healthcare accessibility.

Main results
Nonurgent visits accounted for 51.6% of the 1 499 108 visits during the study period. The admission rate was 2.1% for nonurgent presentations and 18.8% for urgent presentations. In the final multivariate model (n = 1 412 895 visits), after adjustment for sex, age, time of day, day of the week, month, and year, the risk of nonurgent presentation was significantly higher for children living in less advantaged areas and in areas where the rate of single-parent families was high. It was also higher for children living close to the ED.

Conclusion
This extensive retrospective multicenter study emphasizes the increased risk of visiting EDs for nonurgent medical care among children from disadvantaged urban areas.
The reemergence of Streptococcus pyogenes in skin and soft tissue infections: a review of epidemiology, pathogenesis, and management strategies
Authors: Bassetti Matteo , Giacobbe Daniele Roberto , Larosa Barbara , Lamarina Annaflavia , Vena Antonio , Brucci Giorgia 
Published: January 2025

Purpose of review
To discuss skin and soft tissue infections (SSTIs) caused by group A Streptococcus (GAS) by focusing on their pathogenesis, clinical manifestations, and management strategies.

Recent findings
GAS is responsible for a wide range of infections from mild disease to severe fatal invasive infections with high mortality rates. Invasive GAS (iGAS) infections affect both young and old individuals and account for 1.8 million cases worldwide, with a mortality rate of up to 20%. In addition, conditions resulting by immune responses triggered by GAS also contribute to GAS-associated morbidity, and should not be overlooked. GAS has the ability to produce a wide set of virulence factors which contribute to its pathogenicity and its ability to colonize different body site and subsequently cause invasive infections. Management of SSTIs caused by GAS is challenging due to the risk of rapid progression and the risk of developing complications.

Summary
During the COVID-19 pandemic, a relevant increase in iGAS infections has been registered. A constantly updated knowledge of the clinical presentation of iGAS infections is thus necessary to reduce their high mortality rates. Proper recognition and treatment of iGAS infections remain crucial.
99mTc-FAPI-46 Scan and 177Lu-FAPI-2286 Treatment in a Patient With Nasopharyngeal Carcinoma
Authors: Barashki Somaye , Hadad Bentolhoda , Raeisi Nasrin , Aryana Kamran 
Published: January 2025

Abstract
We present a 24-year-old man with a history of metastatic nasopharyngeal cancer. Despite receiving standard treatments, including surgery, radiotherapy, and chemotherapy, he has shown progression. Consequently, he has been referred to the nuclear medicine department for theranostic purposes. The 99mTc-FAPI-46 whole-body scan showed tracer uptake in mediastinal large mass, both external lymph nodes and osseous metastases. Treatment with 177Lu-FAPI-2286 initiated, with subsequent planar scans revealing sustained uptake up to day 10, particularly in the large mediastinal mass. This case indicates promising FAPI-targeted theranostic potential in metastatic nasopharyngeal carcinoma and proper retention of 177Lu-FAPI-2286 in metastatic lesions.
Response Evaluation Using 68Ga-DOTA-IBA in a Case of Metastatic Prostate Cancer
Authors: Li Linwei , Chen Yue 
Published: January 2025

Abstract
We report a case of a patient with metastatic prostate cancer receiving first-line endocrine therapy. Clinical symptoms, PSA level, and CT confirmed the significant progression of his bone metastatic lesions. In comparison to images at baseline, follow-up bone scan incorrectly showed remission of the bone lesions, whereas follow-up 68Ga-DOTA-IBA correctly showed disease progression.
Subcutaneous Infection With Snow Leopard Sign on 18F-FDG PET/CT Mimicking Subcutaneous Panniculitis-Like T-Cell Lymphoma
Authors: Zheng Xinyue , Zhang Tingting , Yan Xiaofang , Su Xinhui , Wang Peipei 
Published: January 2025

Abstract
A 37-year-old man presented with a 2-month history of fever of unknown origin and erythema rashes on the trunk and limbs. 18F-FDG PET/CT revealed increased 18F-FDG uptake in subcutaneous panniculitis, forming a snow leopard sign, along with enlarged lymph nodes, which suggested subcutaneous panniculitis-like T-cell lymphoma. However, skin biopsy indicated subcutaneous infection, and bone marrow biopsy revealed no abnormal lymphocytes. After anti-infection treatment, symptoms improved, leading to a final diagnosis of systemic infection. This case demonstrates how extensive subcutaneous infections on PET/CT could be misinterpreted as subcutaneous panniculitis-like T-cell lymphoma.
High PSMA Avidity, Yet Still Benign
Authors: Reddy Ryan , Ulaner Gary A. 
Published: January 2025

Abstract
A 64-year-old man with newly diagnosed prostate cancer underwent 18F-Piflufolastat PET/CT. Radiotracer avidity localized to the primary prostate malignancy and to a left rib (SUVmax, 9.0). The high 18F-Piflufolastat avidity may have been mistaken for a metastasis if not for the corresponding CT images demonstrating a well-circumscribed sclerotic rim at the site of the PET focus. This CT finding is uncommon for osseous malignancy, but common in benign fibrous dysplasia. Biopsy confirmed benign fibrous dysplasia. This case emphasizes that benign CT morphology may supersede even high avidity on PSMA-targeted PET imaging. Physicians interpreting PET/CT must recognize CT findings that supersede PET findings.
Diversity and seasonality of ectoparasite burden on two species of Madagascar fruit bat,Eidolon dupreanumandRousettus madagascariensis
Authors: Andrianiaina Angelo F. , Andry Santino , Kettenburg Gwenddolen , Ranaivoson Hafaliana Christian , Lacoste Vincent , Dussart Philippe , Heraud Jean-Michel , Laverty Theresa M. , Guth Sarah , Young Katherine I. , Andrianarimisa Aristide , Brook Cara E. 
Published: January 2025

ABSTRACTBackgroundBats are important reservoir hosts for a variety of microparasites, some of which are transmitted by ectoparasite vectors that include mites, fleas, lice, ticks, and bat flies (families Nycteribiidae and Streblidae). All of these ectoparasite taxa are known to parasitize two endemic fruit bats of Madagascar,Eidolon dupreanumandRousettus madagascariensis.We aimed to describe the diversity of ectoparasite infestation for both bat species through morphological observation and DNA barcoding and elucidate ecological and climatic correlates of seasonal nycteribiid parasitism of these hosts.MethodsLiveE. dupreanumandR. madagascariensisfruit bats were captured monthly in northern and central-eastern Madagascar from 2013-2020. Ectoparasites on all captured bats were counted and identified in the field, then collected into ethanol. Field identification of a subset of samples were confirmed via microscopy and DNA barcoding of the cytochrome C oxidase subunit 1 (COI) and 18S genes. The seasonal abundance of nycteribiid bat flies on both host bats was analyzed using generalized additive models, and the role of climate in driving this seasonality was assessed via cross-correlation analysis combined with generalized linear models. Phylogenetic trees were generated to compare COIand 18S sequences of Madagascar nycteribiid and streblid bat flies with available reference sequences from GenBank.ResultsEctoparasites corresponding to four broad taxa (mites, ticks, fleas, and bat flies) were recovered from 628 of 873E. dupreanumand 831 of 862R. madagascariensis.E. dupreanumwere most commonly parasitized byCyclopodia dubianycteribiids andR. madagascariensisbyEucampsipoda madagascariensisnycteribiids orMegastrebla wenzelistreblids. We observed significant seasonality in nycteribiid abundance on both bat hosts, which varied by bat sex and was positively correlated with lagged temperature, precipitation, and humidity variables. Barcoding sequences recovered for all three bat fly species grouped with previously reported sequences, confirming morphological species identification. Our study contributes the first DNA barcodes of any kind reported forM. wenzeliand the first 18S barcodes forC. dubia.ConclusionThis study explores the diversity and abundance of ectoparasite burdens in two Malagasy fruit bat species, highlighting the importance of seasonal ecology and the influence of climate variables on parasitism, which correlates with resource availability.
Limited genetic diversity amongMalassezia furfurisolates during two one-year neonatal and pediatric bloodstream infection surveys confirms preference for one specific IGS1 genotype in deep-seated infections
Authors: Theelen Bart , Cafarchia Claudia , Hagen Ferry , Boekhout Teun 
Published: January 2025

AbstractIn recent years, multiple reports indicated thatMalasseziafungemia may be of emerging concern in immunocompromised patients and neonates. In combination with observations of reduced antifungal susceptibility, this highlights the need for a better understanding of the extent ofMalasseziaetiology in deep seated infections. The use of media without lipid supplementation in most clinics underlines the likelihood of underdiagnosis. Here, we utilize multiple genetic markers to explore the genetic diversity of number oneMalasseziafungemia speciesMalassezia furfur, observed from two one-year surveys investigating neonatal and pediatric bloodstream infections. All strains isolated from skin and deep seated neonatal or pediatric sites belong to IGS1-genotype A, except for nine isolates from one pediatric patient. This confirms previous observations of a preferential genotype for deep seated body sites. The mitochondrialcox3-nad3 intergenic region provided additional typing resolution, and including ITS, translation elongation factor 1-α, chitin synthase 2, and the mating type, 16 genotypes (MF1-16) could be distinguished among all isolates from both surveys and reference isolates. These results present a promising MLST scheme that requires further testing. We observed a decreased genetic variation ofM. furfurisolates among NICU and pediatric surgery patients over the course of 5 years and showed that the skin likely serves as a reservoir for residentM. furfurstrains from where they can enter the bloodstream, causing infections among susceptible patient groups. Overall, reduced susceptibility for amphotericin B and specifically fluconazole was observed.