bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-life data of Pasireotide LAR in acromegaly: a long-term follow-up
Authors: Urbani C. , Dassie F. , Zampetti B. , Mioni R. , Maffei P. , Cozzi R. , Bogazzi F. 
Published: January 2024

Abstract
Objective
Pasireotide LAR (PAS-LAR) was released in Italy in 2017 to treat acromegaly patients resistant to SRLs (Somatostatin Receptors Ligands). The long-term follow-up data of PAS-LAR therapy in Italy are limited. This study aimed to evaluate the efficacy and safety of PAS-LAR in acromegaly.

Design
Patients with acromegaly in PAS-LAR treatment were enrolled in three tertiary Italian endocrinological centers and evaluated by a retrospective observational real-life multicentre study.

Methods
Patients have been studied before (baseline) and 1, 6, 12, 24 and > 36 months after PAS-LAR start. Clinical, biochemical, and pituitary magnetic resonance data were collected, along with information on adverse events. Acromegaly disease activity was classified according to the IGF-1 index (normal value < 1.0).

Results
Fifty patients (female 23) were enrolled. PAS-LAR treatment (mean follow-up 24 ± 16 months) significantly decreased IGF-1 levels (IGF-1 index baseline vs last visit: 1.9 ± 0.6 vs 1.2 ± 0.6, p < 0.0001). At the last visit, 67% of patients had controlled disease, and 44% showed a decrease in tumor volume. Clinical and biochemical efficacy was observed as early as after 1-month of PAS-LAR treatment (IGF-1 index baseline vs 1-month: 1.9 ± 0.6 vs 1.4 ± 0.7, p < 0.0001). Also, 50% of patients referred headache improvement or disappearance. Fifteen patients discontinued PAS-LAR due to failure of treatment and poor glycaemic control. The prevalence of diabetes increased from 33% at the baseline to 54% at the last visit (p = 0.0072).

Conclusion
In real-life settings, PAS-LAR significantly decreases symptoms, IGF-1 levels, and the size of adenoma in patients with acromegaly resistant to SRLs. Beneficial effects may occur early after the first injection.
Fabrication of pollution-free coal gangue-based catalytic material utilizing ferrous chloride as activator for efficient peroxymonosulfate activation
Authors: Sun Zhiming , Wang Xinlin , Jia Shaoran , Liang Jialin , Ning Xiaotian , Li Chunquan 
Published: January 2024

AbstractNovel coal gangue-based persulfate catalyst (CG-FeCl2) was successfully synthesized by the means of calcinating under nitrogen atmosphere with the addition of ferrous chloride tetrahydrate (FeCl2·4H2O). The phase transformation of the prepared materials and gas products during the heating process are thoroughly investigated. It is suggested that ferrous chloride participated in the phase transformation and formed Si-O-Fe bonds. And the main gaseous products are H2O, H2, and HCl during the heating process. Besides, the ability of CG-FeCl2 to activate peroxymonosulfate (PMS) for catalytic degradation of polycyclic aromatic hydrocarbons (PAHs) and phenol was deeply studied. More than 95% of naphthyl, phenanthrene and phenol were removed under optimizied conditions. In addition, 1O2, ·OH, and SO4·− were involved in the CG-FeCl2/PMS system from the free radical scavenging experiment, where 1O2 played a major role during the oxidation process. Furthermore, CG-FeCl2/PMS system exhibited superior stability in a relatively wide pH range and the presence of common anion from related degradation experiments. Overall, the novel CG-FeCl2 is an efficient and environmentally friendly catalyst, displaying potential application prospect in the field of PAHs and phenol-contaminated wastewater treatment.
Low-carbon energy systems: seizing market-based business opportunities across borders
Authors: Kalirajan Kaliappa 
Published: January 2024

AbstractAsia has been experiencing much faster economic growth than the world average and has been consuming more energy and natural resources than our planet’s regenerative capacity can provide. With each passing day, Asia’s carbon emissions have been growing, as does its vulnerability to climate risks. The poor are the most vulnerable to these disruptions, lacking options to adapt to changing climatic conditions. The transition to a low-carbon green growth in almost all of emerging economies in the Asian region is underway. This transition has become unstoppable and irreversible. In this context, it is important to realize that the Coronavirus (COVID-19) pandemic has its own impact on the economies. Nevertheless, it has also created new once-in-a-generation opportunities for implementing hard policy reforms through economic recovery and stimulus packages. The need to accelerate the low-carbon transition as part of the pandemic recovery is unquestionable, but the question is how to do it in a cost-effective way. This research presents a broad diagnosis of new regional cooperation opportunities in areas essential to complete the transition to a low-carbon economy by 2030 and a net zero economy by 2050–2060. It highlights where regional cooperation and coordination can have the greatest impact. It points to a number of policy areas—trade, carbon taxation, carbon pricing, and innovation—where regional cooperation reduces the cost of implementing national actions and complements global pacts. This model also creates business opportunities for developing competitive green industries and low-carbon technologies across countries in the region.
Design and characterization of iron–calcium–aluminium–silicate–hydrate as low-temperature binder
Authors: Tchio Julson Aymard , Yerima Ngu , Kaze Cyriaque Rodrigue , Kamseu Elie , Chinje Florence Uphie , Leonelli Cristina 
Published: January 2024

AbstractThis work aims to synthesize new cementitious materials (binders) using marble powder, rice husk ash, activated laterite and NaOH solution by applying low energy process. The binder was used to stabilize solid precursors (laterite and pozzolan). To achieve this objective, calcium–silicate–hydrate (CSH) was first synthesized at different temperatures (26, 50, 80 and 100 °C). The best physical–mechanical properties were chosen to produce iron–calcium–aluminium–silicate–hydrate [Fe–C(A)SH] at different concentrations of sodium hydroxide solution: 4, 5, 6 M. Finally, the formulated binder at 6 M of NaOH solution was used to stabilize laterite and pozzolans at the following proportions 20%, 30%, 40% and 50%. The samples were characterized after 28 days of curing at room temperature. FT-infrared spectroscopy, X-ray diffraction, and environmental scanning electron microscope ESEM-EDS permitted to confirm the formation of CSH, and Fe–C(A)SH. The mechanical test used to evaluate the performance showed that the incorporation of 10% iron-rich laterite into CSH increased the strength up to 42.93 MPa and the addition of Fe–C(A)SH in the laterite/pozzolans increased the compressive strength of the final product (15.34 and 15.8 MPa for laterite and pozzolan, respectively). The highest concentration (6 M) increases the alkalinity and reduces the efficiency of silicate polymerization affecting the final structural compound. From the results, low-energy Fe–C(A)SH-based cement and stabilized compounds appeared promising for the development of sustainable infrastructures.
Bullying and Autism Spectrum Disorder: Correlating the Victimization of High-Functioning Autism Students with Educational Practices in the Context of Inclusion in Primary Education
Authors: Gkatsa Tatiani , Antoniou Irene 
Published: January 2024

AbstractBullying and victimization in children with autism spectrum disorder (ASD) is a problem of particular importance, as this category of students is at high risk of victimization by other students, which negatively affects their psychosocial and emotional development. The purpose of this study is to investigate the rate of victimization of children with high-functioning autism (AHF) by their peers in primary school, and whether this rate correlates with teachers’ education professionals’ classroom practices for the inclusion. Data collection was conducted using two questionnaires, the Autism Inclusion Questionnaire (AIQ) (Segall & Campbell in Autism inclusion questionnaire, 2007), which explores the educational practices that teachers utilize in terms of including students with ASD in the general classroom (Segall & Campbell in Research in Autism Spectrum Disorders 6(3):1156–1167, 2012), and the questionnaire on victimization of children with ASD by their peers (Belidou in Autism spectrum disorder and victimization: teachers’ views of the association with theory of mind and friendship (Master thesis), 2017). The survey was based on the responses of 143 teachers who teach primary school students diagnosed with high-functioning ASD. The results showed that 34.3% of teachers observed that AHF children are at higher risk of victimization compared to typically developing children. Also, it was found that there are several educational practices of children with autism, which are associated with the victimization of children belonging to the high-functioning autism spectrum.
Is identifying boredom the answer to controlling the bombardment of notifications on mobile devices?
Authors: Kamal Rashid , Rextin Aimal , Nugent Chris , Cleland Ian , McCullagh Paul 
Published: January 2024

AbstractMobile notifications have become ubiquitous in modern life, yet excessive volumes contribute to interruption overload. This paper investigates intelligent notification management leveraging user context. A three-stage methodology employed a focus group, survey, and in-the-wild data collection app. The focus group $$(n=12)$$

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provided preliminary insights into notification perceptions during boredom which informed survey design. The survey $$(n=106)$$

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probed usage habits across times, days, and app categories. The SeektheNotification app gathered real-world notification data from 20 Android users over 3 months.Analysis revealed social and personal apps dominate notification volumes (91% combined). Shorter response delays occurred on weekends and after 12 pm, suggesting heightened user receptivity during boredom. Random Forest classification achieved 88% accuracy, outperforming 13 other algorithms, underscoring machine learning’s potential for context-aware notification systems.Our exploratory findings indicate notifications could be optimized by considering situational factors like boredom. Further research should expand context beyond boredom and employ advanced deep learning techniques. This preliminary study demonstrates the promise of leveraging user psychology and machine intelligence to develop smarter interruption management systems to combat notification overload.
Digitisation and Georeferencing of an Oversized Historical Map of the Bailiwick of Neuland (Winsen/Luhe) using Structure-from-Motion (SFM) Photogrammetry
Authors: Kersten Thomas , Stößel Leon , Lindstaedt Maren 
Published: January 2024

AbstractThe study of historical maps has gained significant importance in recent years due to their ability to shed light on past geographical and topographic landscapes since they serve as crucial sources for understanding past conditions. They not only provide insights into the geography and topography during the time they were created but also allow for studying long-term changes over time. In this study, an oversized historical map of the Bailiwick of Neuland from the years 1780 to 1790 was discovered in the archives of the municipal building office in Winsen an der Luhe, Germany. The map, measuring approximately 5 m × 2 m, was digitised by photogrammetric methods and subsequently georeferenced. The process involved photographing the map with two different cameras and two UAV systems at the Geodetic Laboratory of HafenCity University Hamburg. This allowed to generate a high-resolution orthophoto from each data set. The resulting orthophoto achieved a pixel size of 0.2 mm, ensuring a detailed representation of the map. To ensure accuracy, the best photo block was scaled in a bundle block adjustment using ground control points with an accuracy of 1 mm and scale bars with an accuracy of 0.1 mm. Georeferencing of the historical map was conducted using current digital orthophotos of Lower Saxony with a resolution of 20 cm. A third-degree polynomial transformation was applied during georeferencing, resulting in mean residuals of 2.5 m at the ground control points. This process ensured that the historical map was accurately aligned with the current digital orthophotos, allowing for precise spatial referencing.
Spectral of the nonlinear weighted superposition operator on Fock spaces
Authors: Felke Yonas Eshetu , Mengestie Tesfa , Takele Mollalgn Haile 
Published: January 2024

AbstractWe follow several approaches in nonlinear spectral theory and determine the various spectral forms for the nonlinear weighted superposition operator on Fock spaces. The results show that most of the forms introduced so far coincide and contain singeltons. The classical, asymptotic, and connected eigenvalues, and some numerical ranges of the operator are also identified. We further prove that the operator is both linear and odd asymptotically with respect to the pointwise multiplication operator on the spaces.
How Does the Pinatubo Eruption Influence Our Understanding of Long‐Term Changes in Ocean Biogeochemistry?
Authors: Olivarez Holly C. , Lovenduski Nicole S. , Eddebbar Yassir A. , Fay Amanda R. , McKinley Galen A. , Levy Michael N. , Long Matthew C. 
Published: January 2024

AbstractPinatubo erupted during the first decadal survey of ocean biogeochemistry, embedding its climate fingerprint into foundational ocean biogeochemical observations and complicating the interpretation of long‐term biogeochemical change. Here, we quantify the influence of the Pinatubo climate perturbation on externally forced decadal and multi‐decadal changes in key ocean biogeochemical quantities using a large ensemble simulation of the Community Earth System Model designed to isolate the effects of Pinatubo, which cleanly captures the ocean biogeochemical response to the eruption. We find increased uptake of apparent oxygen utilization and preindustrial carbon over 1993–2003. Nearly 100% of the forced response in these quantities are attributable to Pinatubo. The eruption caused enhanced ventilation of the North Atlantic, as evidenced by deep ocean chlorofluorocarbon changes that appear 10–15 years after the eruption. Our results help contextualize observed change and contribute to improved constraints on uncertainty in the global carbon budget and ocean deoxygenation.
Impacts of Mid‐Pliocene Ice Sheets and Vegetation on Afro‐Asian Summer Monsoon Rainfall Revealed by EC‐Earth Simulations
Authors: Han Zixuan , Power Katherine , Li Gen , Zhang Qiong 
Published: January 2024

AbstractThe impact of mid‐Pliocene boundary conditions on Afro‐Asian summer monsoon (AfroASM) rainfall is examined using the fully coupled Earth System Model EC‐Earth3‐LR. Our focus lies on the effects of varying CO2 concentration, diminished ice sheets and vegetation dynamics. We find that the enhanced AfroASM rainfall is predominantly caused by the “warmer‐gets‐wetter” mechanism due to elevated CO2 levels. Additionally, the ice sheet, similar in size to that of the mid‐Pliocene era, creates several indirect effects. These include sea ice‐albedo feedback and inter‐hemispheric atmosphere energy transport. Such influences result in the southward shift of Hadley circulation and formation of Pacific‐Japan pattern, leading to reduced rainfall in North African and South Asian monsoon regions but increased rainfall in East Asian monsoon region. Interestingly, while dynamic vegetation feedback has a minimal direct effect on AfroASM rainfall, it significantly influences rainfall in the mid‐high latitudes of the North Hemisphere by enhancing water vapor feedback.
Migrating Foreshocks Driven by a Slow Slip Event Before the 2021 MW 6.1 Yangbi, China Earthquake
Authors: Wang Kaiying , Peng Zhigang , Liang Shiming , Luo Jiahong , Zhang Keliang , He Changrong 
Published: January 2024

AbstractForeshocks are known to occur before certain large earthquakes, but the physical mechanism is still in debate. Recent field and laboratory studies have supported either cascade‐triggering, pre‐slip or a combination of both models. Here we use a dense seismic and geodetic network deployed in 2018 in Southwest China to quantify the long‐term background seismicity, short‐term spatio‐temporal evolutions of foreshocks and transient deformation before the 2021 MW 6.1 Yangbi earthquake. We find multiple episodes of migrating foreshocks and repeating earthquakes in the last 4 days of the Yangbi mainshock. A rapid migration of microseismicity started in the last 30 minutes toward the eventual initiation point of the Yangbi mainshock, well beyond the rupture zone of the largest MW 5.2 foreshock at that time. The Coulomb stress changes due to relatively large‐size foreshocks at the mainshock hypocenter are positive but relatively small (0.005–0.05 MPa). We also observe continuous geodetic signals with ∼20 mm of cumulative displacement at a nearby GPS station coinciding with the last hour of intense foreshocks. The inverted aseismic moment is equivalent to a MW 5.56 event with the maximum slip of ∼200 mm at 6 km depth, larger than the cumulative seismic slip of ∼60–120 mm inverted from waveforms of several large M4+ foreshocks. In addition, the predicted surface displacements based on the coseismic slips of the M4+ foreshocks are unobservable in the GPS data. We propose a migratory slow‐slip model where a transient slow‐slip event drives the last hour of foreshock sequence and eventually trigger the Yangbi mainshock.
Buoyant Impact Partial Melts on Ancient Mars
Authors: Black B. A. , Marchi S. 
Published: January 2024

AbstractMost of the Martian crust formed prior to ∼4 Ga, but the magmatic processes responsible for finalizing the structure and composition of the ancient crust remain enigmatic. Impacts can produce large volumes of melt under a wide range of melting pressures, temperatures, and degrees of melting. Hellas, Argyre, Isidis, and Utopia basins date to around 4 Ga, demonstrating that basin‐scale impacts helped to place the finishing touches on an already established crust. In this work, we focus on the ascent and intrusion of impact partial melts generated at mantle depths and the consequences for the petrology and structure of the Martian crust. Specifically, we show that the majority of impact partial melts are buoyant, favoring ascent to the surface or to neutral buoyancy levels in the crust, where magmas solidify as intrusive rocks. The composition of these polybaric melts overlaps with some ancient Martian igneous materials. We propose that the process of ascent of deep‐seated impact partial melts and intrusion at shallower levels may have contributed to the observed crustal stratification and ancient petrologic diversity on Mars.
Late Cretaceous Sevier Versus Laramide Orogenies in Wyoming‐Utah‐Colorado, USA: New Insights From Basin Subsidence History
Authors: Zhou Danya , Liu Shaofeng , Wang Lianbin , Wan Neng , Steel Ronald 
Published: January 2024

AbstractVariability in subsidence rates within Upper Cretaceous strata of the Western Interior Basin offers crucial insights into the response of surface sedimentation styles to Sevier‐to‐Laramide tectonics and related deep mantle processes. The formation mechanisms of the Late Cretaceous Western Interior Basin in North America have long been a subject of debate. A re‐evaluation of the basin's subsidence history reveals rapid subsidence pulses lasting ca. 2 Myr within longer‐term (average 5.7 Myr) progradational or aggradational clastic wedges. The timing of these wedges, especially the widespread marine flooding resulting from subsidence, is constrained through the calibration of ammonite zonation with absolute dates. Sevier wedges exhibit a different architecture compared to the Laramide wedges. The former recorded initial rapid and widespread marine transgressions followed by long‐term coastal progradation, whereas the latter developed by initial erosional and progradational growth followed by aggradation and long‐term coastal transgression. The Sevier clastic wedges, initially accumulated within a N‐S elongated, long‐wavelength tectonic subsidence zone close to the thrust belt, gradually migrated cratonward. Starting in the early Campanian (ca. 82 Ma), the Laramide Orogeny developed along a NW‐SE trend and then migrated northeastward, roughly consistent with coeval long‐wavelength frontal basin subsidence. The spatio‐temporal variations in long‐wavelength tectonic subsidence indicate a shift in the dynamic subsidence's migration direction from eastward to northeastward, driven by changes in Farallon subduction direction and mode. Our work shows how repeated subsidence behavior in the Sevier‐to‐Laramide transition records evolving architectural responses and the trajectory of coeval dynamic topography.
Adipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians
Authors: Gadgil Meghana D. , Cheng Jing , Herrington David M. , Kandula Namratha R. , Kanaya Alka M. 
Published: January 2024

Abstract
Background
South Asians are at higher risk for type 2 diabetes (T2D) than many other race/ethnic groups. Ectopic adiposity, specifically hepatic steatosis and visceral fat may partially explain this. Our objective was to derive metabolite risk scores for ectopic adiposity and assess associations with incident T2D in South Asians.

Methods
We examined 550 participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort study aged 40–84 years without known cardiovascular disease or T2D and with metabolomic data. Computed tomography scans at baseline assessed hepatic attenuation and visceral fat area, and fasting serum specimens at baseline and after 5 years assessed T2D. LC-MS-based untargeted metabolomic analysis was performed followed by targeted integration and reporting of known signals. Elastic net regularized linear regression analyses was used to derive risk scores for hepatic steatosis and visceral fat using weighted coefficients. Logistic regression models associated metabolite risk score and incident T2D, adjusting for age, gender, study site, BMI, physical activity, diet quality, energy intake and use of cholesterol-lowering medication.

Results
Average age of participants was 55 years, 36% women with an average body mass index (BMI) of 25 kg/m2 and 6% prevalence of hepatic steatosis, with 47 cases of incident T2D at 5 years. There were 445 metabolites of known identity. Of these, 313 metabolites were included in the MET-Visc score and 267 in the MET-Liver score. In most fully adjusted models, MET-Liver (OR 2.04 [95% CI 1.38, 3.03]) and MET-Visc (OR 2.80 [1.75, 4.46]) were associated with higher odds of T2D. These associations remained significant after adjustment for measured adiposity.

Conclusions
Metabolite risk scores for intrahepatic fat and visceral fat were strongly related to incident T2D independent of measured adiposity. Use of these biomarkers to target risk stratification may help capture pre-clinical metabolic abnormalities.