bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Imbalanced Heart Sound Classification through Transfer Learning and Gammatonegram Image Analysis
Authors: Singh Sinam Ashinikumar , Singh Sinam Ajitkumar , Singh Aheibam Dinamani 
Published: November 2023

Abstract
Cardiovascular diseases remain the foremost global cause of mortality, necessitating timely and accurate diagnosis. Auscultation, relying on a physician's expertise and a stethoscope, stands as the primary diagnostic tool for cardiovascular disorders. However, its inherent subjectivity necessitates the development of an efficient clinical support system capable of transforming this subjective process into a computerized and proficient method. In real-world clinical settings, auscultation sounds frequently become entangled with ambient noise, demanding the implementation of an effective denoising technique followed by a robust classification model to ensure accurate categorization. In this research paper, we present an innovative preprocessing technique that harnesses the Variational Mode Decomposition (VMD) method to effectively denoise heart sounds. Subsequently, the denoised sound signals undergo processing through a Gammatone filter bank and Short-Time Fourier Transform (STFT) to generate time-frequency distributions in the form of Gammatonegram images and Spectrogram images. To tackle the challenges associated with imbalanced datasets, we incorporate a data augmentation method during the image processing phase. These images are then subjected to classification using various deep convolutional neural network architectures grounded in transfer learning principles, specifically CNN models, including AlexNet, SqueezeNet, GoogLeNet, and VGG19, to mitigate model overfitting.Our experimental results undergo rigorous validation using the publicly accessible PhysioNet 2016 dataset. Notably, our proposed methodology, particularly when leveraging Gammatonegram images, demonstrates highly promising results. These outcomes underscore the considerable clinical potential of our approach, particularly in the context of detecting imbalanced and noisy heart sound signals, ultimately contributing to the enhancement of cardiovascular disease diagnosis.
Data-driven and echo state network-based prediction of wave propagation behavior in dam-break flood
Authors: Li Changli , Han Zheng , Li Yange , Li Ming , Wang Weidong , Chen Ningsheng , Hu Guisheng 
Published: November 2023

Abstract

The computational prediction of wave propagation in dam-break floods is a long-standing problem in hydrodynamics and hydrology. We show that a reservoir computing echo state network (RC-ESN) that is well-trained on a minimal amount of data can accurately predict the long-term dynamic behavior of a one-dimensional dam-break flood. We solve the de Saint-Venant equations for a one-dimensional dam-break flood scenario using the Lax–Wendroff numerical scheme and train the RC-ESN model. The results demonstrate that the RC-ESN model has good prediction ability, as it predicts wave propagation behavior 286 time-steps ahead with a root mean square error smaller than 0.01, outperforming the conventional long short-term memory (LSTM) model, which only predicts 81 time-steps ahead. We also provide a sensitivity analysis of prediction accuracy for RC-ESN's key parameters such as training set size, reservoir size, and spectral radius. Results indicate that the RC-ESN is less dependent on training set size, with a medium reservoir size of 1,200–2,600 sufficient. We confirm that the spectral radius has a complex influence on the prediction accuracy and currently recommend a smaller spectral radius. Even when the initial flow depth of the dam break is changed, the prediction horizon of RC-ESN remains greater than that of LSTM.
Climate change and its effects on the streamflow of an Andean river basin with volcanic activity
Authors: Salas Hernán D. , Florian Carolina , Builes-Jaramillo Alejandro , Valencia Juliana , Mena Darwin , Parra Juan Camilo , Valdés Juan Carlos 
Published: November 2023

AbstractWe use a Generalized Watershed Loading Function (GWLF) model to simulate streamflow in the Gualí River Basin. The model's performance is assessed using metrics such as percentage of bias (PBIAS), Nash–Sutcliffe efficiency (NSE), RMSE–observations standard deviation ratio (RSR), and Kling–Gupta efficiency (KGE) to indicate good performance. Furthermore, we analyze projections of precipitation and streamflow using several global climate models (GCMs) from the Coupled Model Intercomparison Project Phase 6 (CMIP6) and three shared socioeconomic pathways (SSP1-2.6, SSP2-4.5, SSP5-8.5). Despite the uncertainties and coarse resolution, our results show that increases in the mean streamflow and significantly decreasing trends in projected precipitation and streamflow are observed from 2015 to 2099 under the SSP5-8.5 scenario. Furthermore, our findings suggest an increase in long-term mid-flow and low-flow. Moreover, this work provides a methodological framework for hydrological modeling in small tropical river basins, by incorporating data from GCMs while raising concerns and caveats. This study offers valuable insights into the potential effects of climate change on streamflow in an Andean river basin characterized by volcanic activity and significant human impacts. The findings reported here provide useful information for future decisions related to water supply for the social, environmental, and productive sectors in the seven towns within the catchment.
Síndrome deleción de 22q11.2: a propósito de dos casos
Authors: Gutiérrez-Vargas María Camila , Ostos-Alfonso Henry 
Published: November 2023

El síndrome de deleción 22q11 es la microdeleción cromosómica más frecuente, con una prevalencia de 1 en 3 a 6000 nacidos vivos. Se presentarán dos casos femeninos pediátricos con microdeleción en 22q11.2 por hibridación genómica con pérdida de 2.54 Mb y 3 Mb cada uno. Caso 1: 12 años, con convulsiones, rasgos dismórficos, CIA tipo Ostium secundum. Caso 2: 11 años, alteración palatina, hiperlaxitud, hipocalcemia asintomática y deficiencia de vitamina D. Ambos comparten rasgos dismórficos, retraso global del neurodesarrollo y cariotipo normal. Este estudio evidencia rasgos claves del síndrome que permite optimizar el diagnostico en futuros casos.
The Efficacy and Safety of Inetetamab and Pyrotinib in Combination with
Vinorelbine for Second-line Therapy and Beyond in HER2-positive
Metastatic Breast Cancer: A Single-institution Clinical Experience
Authors: Wu Fan , Chen Mulan , Wang Lili , Li Nani , Wu Xiufeng , Chen Xinhua , Hong Yi , Li Chongyin , Lin Lin , Chen Kan , Huang Weiwei , Liu Jian 
Published: November 2023

Background and Objective:
This study aimed to observe the efficacy and safety of inetetamab
and pyrotinib in combination with vinorelbine in second-line therapy and beyond in
HER2-positive metastatic breast cancer (MBC).

Methods:
Patients with HER2-positive MBC admitted to our hospital from January 2016 to December
2021 were selected. For patients who could not receive antibody‒drug conjugates (ADCs)
during second-line (2nd-line) or third-line and beyond (≥ 3rd-line) anti-HER2 therapy, inetetamab +
pyrotinib + vinorelbine was used for treatment until unacceptable adverse events occurred or the
disease progressed, as evaluated by the Response Evaluation Criteria in Solid Tumors (RECIST)
1.1 every 2 cycles. The progression-free survival (PFS), objective response rate (ORR), clinical
benefit rate (CBR), and adverse reactions were recorded. Multivariate Cox regression analysis was
performed to explore the prognostic factors influencing the curative effect.

Results:
Overall, 52 patients were included; 13 patients received 2nd-line treatment, and 39 patients
received ≥ 3rd-line treatment. The median PFS (mPFS) for all patients treated with inetetamab +
pyrotinib + vinorelbine was 7 months. The mPFS of the 2nd-line subgroup was significantly better
than that of the ≥ 3rd-line subgroup (17 vs. 5 months, P = 0.001). The mPFS of the subgroups that
received trastuzumab (H) or trastuzumab and pertuzumab (HP) only was significantly better than
that of the H or HP and tyrosine kinase inhibitor (TKI) subgroups (8 vs. 5 months, P = 0.030). The
mPFS of the HER2 resistance subgroup was better than that of the HER2 refractoriness subgroup
(14 vs. 7 months, P = 0.025). Cox regression analysis showed that the treatment line (2nd-line more
so than ≥ 3rd-line) was an independent prognostic factor for PFS. In addition, the ORR and CBR of
2nd-line patients were significantly higher than those of ≥ 3rd-line patients (69.2% vs. 30.8% and
92.3% vs. 64.1%, respectively). The most common hematological toxicities were leukopenia and
neutropenia, and the most common nonhematological toxicity was diarrhea.

Conclusion:
Inetetamab and pyrotinib in combination with vinorelbine have good efficacy in ≥
2nd-line treatment of HER2-positive MBC with controllable toxicity, and the combination is a new
treatment option, especially for patients who cannot use ADCs in 2nd-line treatment.
Unusual Scenario: Ipsilateral Pelvic Lymph Node Metastasis in High-
Grade Serous Ovarian Carcinoma without Peritoneal Extension - A Case
Report
Authors: Kumar Naina , Rath Ashutosh , Mangla Mishu , Roy Subhrajyoti 
Published: November 2023

Introduction:
Ovarian cancers are the third most common gynecological cancers worldwide
with serous carcinomas being the most common subtype with 90% of them as high-grade carcinomas.

Case Presentation:
In the present case report a 60 years postmenopausal, nulliparous woman presented
with complaints of bleeding per vaginum for 1-2 months with a left-sided solid-cystic ovarian
mass of size 4x5 cm and ipsilateral enlarged external iliac and obturator lymph nodes which were
diagnosed on histopathological examination as high-grade serous ovarian carcinoma (HGSOCs) with
ipsilateral pelvic lymph node metastasis in presence of intact ovarian capsule and no metastatic deposits
over the uterus, contralateral ovary and fallopian tubes, omentum, or any other gross peritoneal
deposits. There was coexisting non-atypical endometrial hyperplasia. The patient was managed successfully
with staging laparotomy with modified radical hysterectomy, and bilateral pelvic lymphadenectomy
followed by six cycles of adjuvant chemotherapy with Paclitaxel and Carboplatin injections.

Conclusion:
Patients with HGSOCs can have varied presentations with unusual involvement of
lymph nodes in the absence of peritoneal spread. Hence, the clinician must be aware of these unusual
presentations for the successful management of such cases.
Eco-friendly Synthesis of Silver Nanoparticles using Bignay (Antidesma bunius) Leaves for Antibacterial Application
Authors: Duerme Khent Ivan , Montano Cathleen , Diamante Eliezer , Fundador Noreen Grace 
Published: November 2023

Background:
Foodborne pathogenic bacteria continue to become a global concern despite
the advancements in food packaging technology. Silver nanoparticles (AgNPs) are widely studied in
the field as they exhibit desirable inhibitory properties against foodborne pathogens. AgNPs are conventionally
synthesized by toxic chemical and physical means; hence, there is a need to seek environmentally
safe alternative routes for producing AgNPs.

Objective:
The study aimed to synthesize AgNPs using bignay (Antidesma bunius) leaf extract and
assess its antimicrobial activity against the common foodborne pathogens S. aureus and E. coli.

Methods:
Bignay leaf extract was characterized using total phenolic content (TPC) assay and 2,2-
Diphenyl-1-picrylhydrazyl (DPPH) assay. AgNPs were produced under optimized pH, temperature,
and incubation time and were characterized using UV-Vis spectroscopy, Fourier Transform Infrared
spectroscopy, and Transmission Electron Microscopy. The antimicrobial activity of AgNPs was evaluated
against S. aureus and E. coli using the Resazurin Microtiter Assay (REMA).

Results:
Bignay leaf extract exhibited a total phenolic content of 0.315 ± 0.015 mg GAE/mg extract
and an IC50 of 36.36 ± 0.003 μg/mL, which suggests its good reducing properties. The AgNPs synthesized
under reaction conditions of pH 7, 45 ºC, and 30 min showed SPR peaks in the range of 412-
426 nm. Particles were spherical with an average size of 23.72 ± 7.30 nm. FTIR analysis revealed
that the phenolic compounds in the extract capped the resulting nanoparticles. AgNPs demonstrated
superior inhibitory activity against S. aureus and E. coli with MIC90 values of 2.90 ± 0.03 and 3.08 ±
0.004 μg/mL, respectively.

Conclusion:
The study was able to develop a green approach for the synthesis of AgNPs with antibacterial
properties using bignay leaf extract.
Multimodal Discourse Analysis Theory Applied to Senior High School English Reading Teaching
Authors: Li Chuangang , Arumugam Nalini , Du Gang , Zhang Xinghui 
Published: November 2023

Reading English is required for high school students to gain language proficiency, enhance their cultural awareness, and broaden their global perspective. This study incorporates the theory of multimodal discourse analysis into English reading teaching for high school students based on the principles of social semiotics and systemic functional linguistics. The results indicate that utilizing multimodal discourse analysis theory in high school English reading enhances students' focus in class and boosts their English reading scores. Additionally, it facilitates their comprehension of text information and establishes a solid basis for developing multiple literacies.

Keywords: Multimodal discourse analysis theory; Senior high school; English reading teaching
Requirements for Application for Cancellation of Peace and Analysis of Decision Concerning Cancellation of Peace
Authors: Firdaus Gilbert , Sulistianingsih Dewi , Pujiono Pujiono 
Published: November 2023

This writing intends to examine the judge’s ruling on the terms of the peace annulment application. The key focus and main objective of the Suspension of Debt Payment Obligations revolves around the Settlement process, aiming to achieve a peace proposal in accordance with Article 281 of the Bankruptcy and Postponement of Debt Payment Obligations Law, commonly referred to as Law Number 37 of 2004. This occurs within the framework of the Commercial Court's management of the Suspension of Debt Payment Obligations case. If the debtor fails to keep their promise or fulfill the terms of the peace agreement, there is a legal solution to request the annulment of the peace. This research employs a normative juridical method with a descriptive-analytical approach to comprehensively and deeply describe the circumstances or symptoms studied in relation to the conditions for peace annulment applications and the application of these conditions to Decision Number 2/Pdt.Sus-Cancellation of Peace/2023/PN.Niaga Sby Jo. Number 69/Pdt.Sus-PKPU/2020/PN.Niaga Sby. It can be analyzed from the research that the regulations for requesting the annulment of a peace agreement are already established in Law Number 37 of The Year 2004. Article 170, along with Article 171 and Article 291 of the same law, forms the legal basis for the request, specifically addressing issues related to bankruptcy and the postponement of debt payment obligations.
Dimension of uncountably generated submodules
Authors: DAVOUDIAN Maryam 
Published: November 2023

In this article we introduce and study the concepts of uncountably generated Krull dimension and uncountably generated Noetherian dimension of an $R$-module, where $R$ is an arbitrary associative ring. These dimensions are ordinal numbers and extend the notion of Krull dimension and Noetherian dimension.
They respectively rely on the behavior of descending and ascending chains of uncountably generated submodules.
It is proved that a quotient finite dimensional module $M$ has uncountably generated Krull dimension if and only if it has Krull dimension, but
the values of these dimensions might differ.
Similarly, a quotient finite dimensional module $M$ has uncountably generated Noetherian dimension if and only if it has Noetherian dimension.
We also show that the Noetherian dimension of a quotient finite dimensional module $M$ with uncountably generated Noetherian dimension $\beta$ is less than or equal to $\omega _{1}+\beta $, where $\omega_{1}$ is the first uncountable ordinal number.
Contemporary Ecosophies and Ecorhythmology
Authors: Berszán István 
Published: November 2023

Abstract
The present paper compares the author’s original proposal called ecorhythmology with contemporary ecophilosophies. After briefly outlining the background and results of more than two decades of research, it examines the seminal theses of Object Oriented Ontology (Graham Harman), Action Network Theory (Bruno Latour) and the concept of being ecological (Timothy Morton) from an ecorhythmological perspective. Taking stock of interesting similarities and correspondences, this analysis also raises new questions, to which the author proposes different solutions. The paper presents two critiques of the reductionism of string theory and compares Harman’s theory of metaphor with the concept of art based on gestural resonance. Further investigations connect Latour’s redistribution of agency to the intersubjective relationship between the human and non-human, and relate hybridity to proximity. In the second part of the paper, Morton’s different temporalities are juxtaposed with rhythmic dimensions, and finally, the article makes a difference between the casual, political and ethical approaches to the phenomenon of tuning. The stakes are always learning and relearning what kind of contact making can lead to greater peace in difficult human – non-human coexistence.
There is no Other Air Here, we are Alive With the Air of the Paltinsky Meadow…”
Authors: Radics Rudolf 
Published: November 2023

Abstract
The focus of this paper is an ecocritical examination of Ádám Bodor’s The Birds of Verhovina. The study begins with an introduction to Hubert Zapf ’s theory of sustainable texts and the ecocritical concept of Greg Garrard’s Ecocriticism, and concludes with an interpretation of the chosen work along ecocritical tropes. The paper starts from the premise that Ádám Bodor’s work employs the rhetoric of ecocriticism, thereby closely linking literature to a wider web of discourses on nature and the environment. The hypothesis of the study is that the relationship between human and nature, nature and culture, and power and the individual are emphasised in the work. The inhabitants of Verhovina live in harmony with nature; wild and untamed nature not only provides the community with raw materials, but also creeps into the consciousness of the characters, determining their behaviour, their attitudes towards each other, as well as their way of thinking about life. However, the various signs of this shift of power suggest that a rupture has occurred in the hitherto harmonious relationship between the community and nature, the individual and nature.
It is Possible to Work with Them and Develop such a Mutually Good Relationship…”
Authors: Balogh Pál Géza 
Published: November 2023

Abstract
In this study, I examine the complex intertwining of the relationship between man and nature through the activities of a typical group of farmers dominated by urban-rural farmers, the artisan cheese makers of Hungary. I focus on a specific issue, raw milk cheese making, where humans and microbes work together on a daily basis to produce a sellable product. In this context, I will describe how the complex, hybrid nature of the knowledge required for this process of cheese making is produced, and then review the different narratives of Hungarian cheesemakers about the method. I will then show how this method and the particular perspective it entails affects the daily practice of farming, and how working with invisible microbes transforms the fundamental way these farmers think about the relationship between humans and non-human actors.
Complications in Classifying Suicide Incitement as a Crime
Authors: Matua Nukri 
Published: November 2023

Abstract
The article describes and evaluates Georgian legislation in comparison to foreign legislation, as well as, based on the practical analysis, highlights the critical elements of the actual composition leading to suicide and suicide attempt. The problem of identifying whether a crime leading to suicide, or a suicide attempt qualifies for prosecution before investigative bodies and national courts is the main concern. Because of this, the article analyzes topics covered by European and National Court judgments on human rights. The intricacies of the suicide investigation are explained based on the author’s personal professional and practical knowledge, likewise, the conditions that need to be proven all through the case investigations. This article provides an overview of the problems with the current legislative architecture, its weaknesses, and basic suggestions for improving them.
Genesis of Legal Regulation of Pre-Trial Detention in Sweden and Ukraine: Comparative Analysis
Authors: Melnykova Dariia 
Published: November 2023

Abstract
The paper goes on to discuss the prevalence of issues in pre-trial detention practices in both Sweden and Ukraine, as noted by international and national organizations. Sweden has witnessed a growing trend in pre-trial detention statistics, while Ukraine, despite a decreasing trend in remand, faces a substantial number of cases brought against it at the European Court of Human Rights (ECHR) pertaining to pre-trial detention. The historical context reveals that these two countries have responded differently to criticism and challenges, reflecting variations in their legal systems and corresponding regulations on pre-trial detention. Nonetheless, both nations have pursued reforms with a shared objective: to improve the pre-trial detention system. Given these divergent experiences, statistical data, and overall context, it is evident that a comparative analysis of pre-trial detention policies in Sweden and Ukraine is warranted. Such a comparison can offer valuable insights into the existing problems in both countries and suggest pertinent solutions, taking into consideration their distinctive experiences and circumstances.
QUO Quadis Romanian Education? Brief Introspection
Authors: Vedinaş Verginia , Godeanu Teodor Narcis 
Published: November 2023

Abstract
This study aims to conduct a brief introspection of the current state of Romanian education, in general and of academic education, in particular. The approach is achieved under four coordinates: legislative evolution; a review of constitutional and legal provisions; a critical approach to academic education and possible solutions.