bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an advanced velocity modulator for a portable Mössbauer spectrometer
Authors: Yoon Joanne , Lee Jaegi , Ye Sung-Joon , Bang Young-bong 
Published: November 2023

AbstractMössbauer spectroscopy is a nuclear spectroscopic technique that measures changes in energy on an atomic scale. In a Mössbauer spectrometer, a velocity modulator oscillates a radioactive source to vary the energy of gamma rays. Conventional velocity modulators use wires primarily as motion guides; however, the tension state of these wires may change over time. Membrane springs are thus used as an alternative to wires; however, they also present certain challenges related to their design, manufacturing, and assembly. Instead of wires or membrane springs, this study used a linear bearing with preloaded compression springs. The advantage of this mechanism is that permanent deformation or changes in spring stiffness minimally occur during spring assembly and operation. The developed velocity modulator is compact and light, making it ideal for portable applications. A digital controller is used to easily modify and customize control parameters and the supporting algorithm, which is not easily achieved with conventional analog controllers. Moreover, by applying a switching amplifier, low-power operation is also achieved. Feedforward control values are calculated by an iterative learning method that is robust to the control of repeated motion. Using finite element method simulations and experiments, the performance of the developed prototype was evaluated. The velocity signal demonstrated linearity with a correlation with a straight line of approximately 0.996 for a triangular velocity profile (satisfactory performance).
Data-driven prediction of the shear capacity of ETS-FRP-strengthened beams in the hybrid 2PKT–ML approach
Authors: Tran Thai Son , Stitmannaithum Boonchai , Van Hong Bui Linh , Nguyen Thanh-Truong 
Published: November 2023

AbstractA new approach that combines analytical two-parameter kinematic theory (2PKT) with machine learning (ML) models for estimating the shear capacity of embedded through-section (ETS)-strengthened reinforced concrete (RC) beams is proposed. The 2PKT was first developed to validate its representativeness and confidence against the available experimental data of ETS-retrofitted RC beams. Given the deficiency of the test data, the developed 2PKT was utilized to generate a large data pool with 2643 samples. The aim was to optimize the ML algorithms, namely, the random forest, extreme gradient boosting (XGBoost), light gradient boosting machine, and artificial neural network (ANN) algorithm. The optimized ANN model exhibited the highest accuracy in predicting the total shear strength of ETS-strengthened beams and ETS shear contribution. In terms of predicting the total shear strength of ETS-strengthened beams, the ANN model achieved R2 values of 0.99, 0.98, and 0.96 for the training, validation, and testing data, respectively. By contrast, the ANN model could predict ETS shear contribution with high accuracy, with R2 values of 0.99, 0.99, and 0.97 for the training, validation, and testing data, respectively. Then, the effects of all design variables on the shear capacity of the ETS-strengthened beams were investigated using the hybrid 2PKT–ML. The obtained trends could well appraise the reasonability of the proposed approach.
Optimization of oil yield of Pelargonium graveolens L'Hér using Box-Behnken design in relation to its antimicrobial activity and in silico study
Authors: Wafa Sanagik Sabry Abu El , El-Ashmawy Ahmed A. , Kassem Hanaa A. H. , Eissa Ibrahim H. , Abu-Elghait Mohammed , Younis Nermin A. , Younis Inas Y. 
Published: November 2023

AbstractPelargonium graveolens L'Hér is an important species of genus Pelargonium with an economic value. The unique rose scent of its oil is used in perfume and cosmetic industry. The oil is characterized by the presence of citronellol, geraniol and rose oxide. Fresh aerial parts of P. graveolens at GC–MS analysis of four seasons revealed that autumn constituted the highest yield of the oil. For the first time, optimization of the yield of extracted oil of P. graveolens was performed employing 3-level Box-Behnken design using 3-factors. The GC–MS analysis of the essential oil was performed for the 17-runs. The optimized extraction of the oil was performed employing numerical optimization and studied for antimicrobial, Minimum Inhibitory Concentration (MIC) and biofilm inhibitory activities. The 3 factors followed rank (plant material amount > water volume > NaCl percent in water), in their magnitude of effect on increasing yield of the oil. Increasing the plant material amount increased the yield of the oil by 6-folds compared to NaCl percent in water. The optimized yield of oil (4 ml) was obtained from extraction criteria (150 g of plant, 750 ml of water and 3.585% (26.85 g) of NaCl). Computational docking was performed to overcome the multi-drug resistant Gram-negative bacilli targeting undecaprenyl pyrophosphate synthase (UPPS). The optimized oil exhibited a promising inhibitory activity against Gram-negative bacteria (K. pneumonia and P. aeruginosa) with significant antibiofilm action (P < 0.05). Moreover, it exerted a synergistic effect when combined with various antibiotics (Cefoxitin, Cloxacillin, Oxacillin and Vancomycin) against MRSA clinical strains.
Gezielte medikamentöse Therapie der pulmonalarteriellen Hypertonie bei Patient*innen ohne Komorbiditäten
Authors: Klose Hans , Harbaum Lars , Richter Manuel J. , Lichtblau Mona , Marra Alberto M. , Kabitz Hans-Joachim , Harutyunova Satenik , Milger-Kneidinger Katrin , Lange Tobias J. 
Published: November 2023

ZusammenfassungDie neuen Leitlinien der European Society of Cardiology (ESC) und European Respiratory Society (ERS) von 2022 zur pulmonalen Hypertonie fassen die aktuelle Evidenz zusammen und legen Therapiestrategien dar. Um der veränderten klinischen Präsentation der Patient*innen, bei denen eine pulmonalarterielle Hypertonie (PAH) in Europa diagnostiziert und behandelt wird, Rechnung zu tragen, werden Behandlungsempfehlungen für Patient*innen mit und ohne kardiopulmonale Komorbiditäten unterschieden. Dieser Artikel stellt die gezielte Therapie der PAH bei Patient*innen ohne kardiopulmonale Komorbiditäten vor und konzentriert sich auf Patient*innen mit idiopathischer, hereditärer, medikamenten-/toxinassoziierter oder mit Bindegewebserkrankungen-assoziierter PAH. Bei diesen Patient*innen orientiert sich die Therapieeinleitung und Anpassung im Krankheitsverlauf an einer multiparametrischen Bewertung des Mortalitätsrisikos. Für Patient*innen mit niedrigem oder intermediärem Risiko wird eine initiale, orale Kombinationstherapie (Phosphodiesterase-5-Inhibitor und Endothelin-Rezeptor-Antagonist) empfohlen. Bei Patient*innen mit hohem Risiko sollte eine Dreifach-Kombinationstherapie mit einem i. v./s. c. Prostazyklin-Analogon in Betracht gezogen werden. Wenn unter der Therapie ein niedriger Risikostatus nicht erreicht wird, sollte eine sequentielle Therapieerweiterung mit einem Prostazyklin-Rezeptor-Agonisten oder einem Prostazyklin-Analogon in Betracht gezogen werden. Alternativ kann eine Umstellung des Phosphodiesterase-5-Inhibitors auf einen Guanylatzyklase-Stimulator erwogen werden.
Medikamentöse Therapie der pulmonalarteriellen Hypertonie mit Komorbiditäten – Welche Phänotypen gibt es, was gibt es zu beachten?
Authors: Grünig Ekkehard , Halank Michael , Neurohr Claus , Behr Jürgen , Milger-Kneidinger Katrin , Ronczka Julia , Lichtblau Mona , Benjamin Nicola , Lange Tobias J. , Ulrich Silvia , Wilkens Heinrike , Grohé Christian , Skowasch Dirk 
Published: November 2023

ZusammenfassungIm letzten Jahrzehnt hat sich aufgrund zunehmenden Alters bei Erstdiagnose eine Veränderung des klinischen Phänotyps mit einem vermehrten Vorkommen von Komorbiditäten bei der pulmonalarteriellen Hypertonie herausgebildet. Durch Clusteranalysen von Registerdaten wurden insbesondere ein kardialer, kardiopulmonaler und klassischer Phänotyp identifiziert.Daten aus Subgruppenanalysen randomisierter, kontrollierter Studien und Registerdaten konnten bereits darauf hinweisen, dass auch bei Patient*innen mit pulmonalarterieller Hypertonie und kardialen Komorbiditäten, v. a. vom Linksherzphänotyp, ein Kombinationstherapieversuch unter engmaschiger Kontrolle des Therapieerfolgs und der unerwünschten Wirkungen erwogen werden kann. Das 4-Strata-Modell kann für das Monitoring und die Risikostratifizierung verwendet werden.Die individuelle Therapieentscheidung sollte im Zentrum für pulmonale Hypertonie getroffen werden. Dabei sollten Faktoren wie Hämodynamik, Alter, Phänotyp, Anzahl und Schwere der Komorbiditäten, Therapieansprechen, Nebenwirkungen und Patient*innenwunsch berücksichtigt werden. Prospektive, randomisierte Studien zur Einschätzung der Wirksamkeit und des Nebenwirkungsprofils bei pulmonalarterieller Hypertonie mit Komorbiditäten wären wünschenswert.Patient*innen mit einem überwiegend pulmonalen Phänotyp (Rauchen, DLCO < 45 % und/oder Lungengerüstveränderungen im CT) sprechen nach den bestehenden Daten möglicherweise weniger gut auf orale Medikamente an.
Allgemeine Maßnahmen und Management der pulmonalarteriellen Hypertonie
Authors: Lichtblau Mona , Harutyunova Satenik , Nechwatal Robert , Mayer Laura , Kabitz Hans-Joachim , Wilkens Finn Moritz , Uiker Sören , Grünig Ekkehard , Ritter Daniel , Florea Andreea , Benjamin Nicola 
Published: November 2023

ZusammenfassungDie Betreuung von Patienten mit pulmonalarterieller Hypertonie (PAH) erfordert ein multimodales Konzept und Management vielschichtiger Maßnahmen, die die medikamentöse Therapie für das Management von Nebenwirkungen und der Rechtsherzinsuffizienz umfassen sowie die Aufklärung u. a. über Schwangerschaft und Flugreisen, psychosoziale Unterstützung, körperliches Training und Prophylaxe durch Impfungen.Positive Studienergebnisse haben zu einer gesteigerten Empfehlung eines spezifischen Trainings bei pulmonaler Hypertonie geführt. Auch wurde die Empfehlung zur Eisengabe auf die aktuelle Evidenzlage angepasst.Besonderen Fokus hat in den aktuellen Leitlinien die Ausarbeitung der Empfehlungen zu Schwangerschaftsaufklärung und Verhütung sowie dem Management einer Schwangerschaft erhalten.
In diesem Artikel soll ein Überblick über die Empfehlungen zu allgemeinen Maßnahmen und zum Management der PAH gemäß ESC/ERS-Leitlinien gegeben werden. Ergänzungen der Leitlinienempfehlungen wurden durch die Autoren als Kommentare gekennzeichnet.
Diabetes mellitus und kardiovaskuläre Prävention
Authors: Kellerer Monika , Qiu Hui Jing 
Published: November 2023

ZUSAMMENFASSUNGMenschen mit Diabetes leiden überproportional häufig an Herzkreislauferkrankungen. Hierzu tragen auch komplexe metabolische Veränderungen und vermehrte Freisetzung von inflammatorischen Zytokinen aus dem Fettgewebe bei. Nicht zuletzt aufgrund der Herzkreislauferkrankungen liegt ein mindestens zweifach erhöhtes Risiko für einen frühzeitigen Tod im Vergleich zu Menschen ohne Diabetes vor, und die Lebenserwartung ist im Durchschnitt um etwa 5–6 Jahre kürzer. Zur Prognoseverbesserung von Menschen mit Diabetes ist eine Reduzierung der kardiovaskulären Risikofaktoren unabdingbar.
When Reading Gets Ruff: Welfare Challenges and Strategies in an Elementary School Dog-Assisted Literacy Program
Authors: Kirnan Jean , Thompson Ashley 
Published: November 2023

Abstract
The co-authors of this case report have worked collaboratively for over 10 years in a dog-assisted literacy program at an elementary school. In their roles as a teacher and a dog handler, the authors are able to provide unique insights into the challenges and strategies of successfully implementing a school-wide program. This case report addresses animal and participant welfare considerations in the specific areas of recruiting and selecting dog-handler teams, preparing teachers and students, program adaptations for differing abilities, and navigating loss due to separation or retirement. While the examples and anecdotes are from elementary children in a reading program, readers interested in animal-assisted interventions (AAIs) in other settings and with different clients can also benefit as the discussion is broad and the topics relevant to many interventions. Readers are encouraged to exercise proper preparation and planning, as well as consider the various challenges discussed, as a way to facilitate the implementation of future AAIs.

Information
© The Authors 2023
Bird Watching Tourism in Sustainable and Accessible Destinations: The Case of the Entrepreneurial Venture Explora Caloccita in the Mexican Pacific Coast
Authors: Ramos Kenia , Pérez Luis Rubén , Bassols Narcís 
Published: November 2023

Summary
Bird watching is an activity that may prompt sustainable tourism development in remote communities. This case study lays out some lessons learned from the entrepreneurship case Explora Caloccita, a young venture offering bird watching to tourists in the Mexican Pacific coast. This case is based on descriptive research, laying out the practitioners’ insights and analysing the supply of experiences related to bird watching. The innovative vision of the entrepreneurs, the financial and logistical backing by the local hotel La Quinta, and the support of residents and local tour operators allow for the conclusion that bird-watching tourism has been, in this particular case, a sustainable economic alternative. Furthermore, the entrepreneurship Explora Caloccita is embedded in a destination that strongly supports accessible tourism, sustainable local development and nature preservation. The venture and the place’s sustainability are both possible thanks to the strong connections among all stakeholders and residents in the area, as locals also support the bird-watching routes and thus contribute to the conservation of the native and migrant bird species.

Information
© The Authors 2023
Integration of FDM and self-healing technology: evaluation of crack sealing by durability and mechanical strength
Authors: Hameed Noor A , Othman Farhad M , Abdul-Hamead Alaa A 
Published: November 2023

Abstract
The tensile zone of concrete is prone to cracking due to its limited ability to withstand tension. To address this issue, steel reinforcement is used in these specific regions. The occurrence of little cracks might potentially facilitate the ingress of liquids and gases into the reinforcing material, hence inducing corrosion. Self-healing concrete can repair and seal minuscule cracks, thus impeding the formation of corrosion. This study investigates the potential application of fused deposition modeling (FDM) for generating novel vascular networks and tubes using polylactic acid (PLA) as the material. Poly (lactic acid) (PLA) was fabricated using three-dimensional (3D) printing techniques, and its properties were compared to those of one-dimensional (1D) and two-dimensional (2D) networks. The external diameter measured 5.6 mm, while the internal diameter measured 4 mm. utilized a 10 ml volume to apply healing agents, specifically organic polyethylene glycol liquid and nano-powder (fly ash) derived from recycled materials, to all vascular structures (1D, 2D, and 3D). This application was carried out using a planetary ball mill. Following this, the prepared tubes were incorporated into a concrete beam to introduce self-healing capabilities. The water-to-cement ratio (W/C) utilized for all concrete mixtures was 0.6%, while the definite mixture proportions were 1:2.16:2.98. The quantification of the self-healing phenomenon was conducted by evaluating the restoration of load-carrying capacity following the application of a repaired specimen to a four-point bending test. Furthermore, these enhancements resulted in improved durability, increased compressive strength, and enhanced other physical characteristics. The pipes that are manufactured can be utilized to produce innovative concrete that possesses the ability to undergo self-healing processes by combining low-viscosity healing solutions (PEG) with powders (nano fly ash) that are appropriate for this application by injection into the vascular network , making it well-suited for various self-healing applications.
Sexually Transmitted Dermatophytes Can Cause Severe Infection Among Men who Have Sex With Men as Tinea Genitalis
Authors: Chromy David , Osmers Anthea-Margaux , Bauer Wolfgang Michael , Touzeau-Roemer Veronique , Borst Carina , Esser Stefan , Weninger Wolfgang , Willinger Birgit , Grabmeier-Pfistershammer Katharina 
Published: November 2023

AbstractVery limited data on tinea genitalis, a potentially severe dermatophytosis transmitted during sexual intercourse affecting the genital area, suggest its potential to cause outbreaks. Thus, we investigated genital dermatophyte infections at an HIV/sexually transmitted infection clinic and identified 17 men who have sex with men (all people with HIV or pre-exposure prophylaxis users) diagnosed with tinea genitalis.
The soft X-ray background with Suzaku. II. Supervirial temperature bubbles?
Authors: Sugiyama Hayato , Ueda Masaki , Fukushima Kotaro , Kobayashi Shogo B , Yamasaki Noriko Y , Sato Kosuke , Matsushita Kyoko 
Published: November 2023

Abstract
Observations of the hot X-ray emitting interstellar medium in the Milky Way are important for studying the stellar feedback and for understanding the formation and evolution of galaxies. We present measurements of the soft X-ray background emission for 130 Suzaku observations at 75° &lt; l &lt; 285° and |b| &gt; 15°. With the standard soft X-ray background model consisting of the local hot bubble and of the Milky Way halo, residual structures remain at 0.7–1 keV in the spectra of some regions. Adding a collisional-ionization-equilibrium component with a temperature of ∼0.8 keV, much higher than the virial temperature of the Milky Way, significantly reduces the derived C-statistic for 56 out of 130 observations. The emission measure of the 0.8 keV component varies by more than an order of magnitude: assuming the solar abundance, the median value is $3 \times 10^{-4}\, \rm {cm^{-6}\ pc}$ and the 16th–84th percentile range is $(1\!-\!8) \times 10^{-4}\, \rm {cm^{-6}\ pc}$. Regions toward the Orion–Eridanus superbubble, having a large cavity extending from the Ori OB1 association, have the highest emission measures of the 0.8 keV component. While the scatter is large, the emission measures tend to be higher toward lower galactic latitudes. We discuss possible biases caused by the solar wind charge exchange, stars, and background groups. The 0.8 keV component is probably heated by supernovae in the Milky Way disk, possibly related to Galactic fountains.
Effects of Early Aquatic Experience on Motor and Physiological Outcomes in Infants and Children Under 36 Months: A Systematic Review and Meta-analysis
Authors: Yen Hannah , Allen Diane D. , Anderson David I. 
Published: November 2023

Background and Purpose:
Early aquatic experiences may benefit infants and young children with and without developmental delays, but research is limited. Our purpose was to review aquatic experience effects on motor skill, heart rate, and weight gain for participants younger than 3 years of age.

Methods:
PubMed, Science Direct, and CINAHL were searched from inception through February 2022. Included studies examined infants and children younger than 36 months having aquatic experiences, compared with not having or prior to aquatic experiences, and reported outcomes that included motor skills, heart rate, or infant weight gain. Studies were assessed for quality and potential bias using the PEDro or STROBE checklists. Effect sizes were calculated as the standardized mean difference (Cohen's d; 95% confidence interval) within and between groups in individual studies and combined across studies using random-effects models.

Results:
Twelve of 16 articles met the criteria, with 110 participants in studies assessing motor skills, 58 participants in studies assessing heart rate, and 421 newborns in studies assessing infant weight gain. Significant within-group effects were found in motor skills (d = 1.16; 0.09, 2.23), heart rate (d = −0.93; −1.54, −0.31), and weight gain (d = 1.01; 0.09, 1.92). Between-group effects were not significant in motor skills (d = 0.48; −0.49, 1.44), but were significant in newborn weight gain (d = 0.63; 0.43, 0.83). No articles reported between-group data for heart rate.

Discussion and Conclusions:
Moderately strong evidence supports the beneficial effects aquatic experiences have in infants and young children. Limitations include heterogeneity across aquatic experience protocols and measures, retrospective study design for one study, and lack of recommendations for optimal timing and duration for protocols. Additional research is needed to determine effectiveness in subpopulations at developmental risk.
Development of a Nomogram for Predicting the Risk of Hospital-Acquired Pressure Injuries in Patients in the Cardiovascular Intensive Care Unit
Authors: Li Hao-yue , Zhang Yan , Shui Xiao-lan , Che Zhi-gang , Liu Qi-fan , Guo Shan-shan 
Published: November 2023

AbstractPurposeHospital-acquired pressure injuries (HAPIs) increase the medical burden of patients in the cardiovascular intensive care unit (CCU). Thus, identification of CCU patients with a risk for HAPIs is important. To establish a nomogram model for predicting the occurrence of HAPIs in patients in the CCU.MethodsThis was a retrospective cohort study in patients in the CCU at our hospital who developed HAPIs between January 2023 and June 2023. Patient data were extracted from the hospital’s information management system. Risk factors for HAPIs were identified using univariate and multivariate logistic regression analyses and the screened indicators were integrated into a nomogram. The effectiveness of the nomogram was evaluated and verified using receiver operating characteristic curve and decision curve analysis (DCA).ResultsIn this study, a total of 161 patients were enrolled. Univariate logistic regression analysis showed that vasopressor use (OR=2.51, 95%CI=1.24–5.09,p=.010) and NT-proBNP (OR=2.92, 95%CI=1.45–5.92,p=.003), lactic acid (OR=9.43, 95%CI=4.15–21.41,p<.000), procalcitonin (OR=1.37, 95%CI=1.07–1.75,p=.012), D-dimer (OR=1.16, 95%CI=1.05–1.28,p= .004), and albumin (OR=0.88, 95%CI=0.81–0.95,p=.002) levels were independent risk factors for HAPIs. Multivariate logistic regression analysis showed that vasopressor use (OR=3.05, 95%CI=1.20–7.73,p=.019) and lactic acid (OR=12.05, 95%Cl=4.13–35.21,p<.000), procalcitonin (OR=1.30, 95%Cl=1.01–1.69,p=.043) and albumin (OR=0.82, 95%Cl=0.73–0.93,p=.002) levels were independent risk factors for HAPIs. The nomogram was well-calibrated and showed good discriminative ability (AUC=.87). The DCA showed a better net benefit, and the results were confirmed within the validation cohort.ConclusionThe nomogram model developed in this study showed good predictability and can identify patients at risk of developing HAPIs and aid the formulation of targeted interventions.