bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating concentrations of vitamins C, D and E vary with age but not with pneumonia status in foals during the first 5 months of life
Authors: Helbig Hannah , Berghaus Londa J. , Venner Monica , Berghaus Roy , Hart Kelsey A. 
Published: January 2025

AbstractBackgroundAdequate vitamin availability is vital for cellular and immune function and for normal growth. Available data on age‐related changes in serum concentrations of vitamins in foals are limited. In addition, associations between circulating vitamin concentrations and the development of bronchopneumonia in foals are not described.Objectives(1) To quantify circulating concentrations of vitamins C, D and E from birth to weaning in foals; (2) to determine associations between vitamin concentrations and the development of bronchopneumonia during this period.Study designProspective cohort study.MethodsBlood samples were serially collected from 100 initially healthy Warmblood foals from birth to 5 months of age. Health status was evaluated weekly, and the development of subclinical and clinical bronchopneumonia was recorded. After weaning, foals were allocated to healthy, subclinical and clinical pneumonia groups, and samples from 15 foals/group were randomly selected for vitamin C, D and E quantification via ELISA and HPLC. Data were analysed with linear mixed models (p < 0.05).ResultsCirculating concentrations of vitamins C, D and E did not differ between healthy foals and foals with subclinical or clinical pneumonia. Foal age significantly impacted vitamin concentrations (p < 0.001) in a vitamin‐specific manner. Vitamins C and E concentrations increased during the first week of life and then decreased until weaning. Vitamin C concentrations were higher at pneumonia diagnosis in foals with pneumonia diagnosed at or before 8 weeks of age than in healthy foals. Vitamin D concentrations were lowest on Day 7 and then increased steadily until weaning.Main limitationsA small number of foals was included, and results may be specific to this study population due to environmental and farm management factors.ConclusionsCirculating concentrations of vitamins C, D and E vary with age in foals, but do not appear to be related to the development of bronchopneumonia.
Intrinsic Value, Transaction Price Movement, and Cointegration
Authors: Hardin William G. , Jiang Xiaoquan , Wu Zhongua , Zhang Qianying 
Published: January 2025

ABSTRACTThe commercial real estate market provides a unique environment to evaluate the movement of transaction price to intrinsic value. Given the latent nature of intrinsic value, empirical assessment has been difficult. Long‐term use of both judgment (appraisal)‐ and transaction‐based values in real estate to provide tradable price and return benchmark allows testing of the intrinsic value to price relation. Based on NCREIF property return data from 1984 to 2019, we show that the transaction‐based index (TBI) and the appraisal‐based index (NPI) are cointegrated, and the error correction term forecasts TBI returns but not NPI returns. These results indicate that when short‐run deviation occurs, it is the TBI not the NPI that eventually converges back to the equilibrium state of the TBI–NPI system. Further tests reveal that the common trend of the TBI–NPI cointegrated system is associated with the income stream from commercial properties (a fundamental variable).
Stakeholder orientation and insider trading
Authors: Akbulut Mehmet E. , Staer Arsenio , Ucar Erdem 
Published: January 2025

AbstractUsing the staggered adoption of constituency statutes across US states as an exogenous shock to stakeholder orientation, we examine its impact on opportunistic insider trading. We show a strong mitigating effect of stakeholder orientation on insider trading. We find that firms incorporated in states that passed stakeholder constituency statutes have a lower likelihood of opportunistic insider purchases, particularly in environments characterized by high information asymmetry and weak monitoring. Additionally, we find that stakeholder orientation mitigates other measures of financial misconduct, like securities class action lawsuits and financial misstatements. Our results are supported by a variety of robustness and causality tests.
Determinants of limitations in activities of daily living among community‐dwelling persons aged 80 years and older: Longitudinal national evidence from the Health, Aging and Retirement in Thailand study, 2015–2022
Authors: Pengpid Supa , Peltzer Karl , Hajek André , Gyasi Razak M 
Published: January 2025

AimFew studies have longitudinally assessed the determinants of limitations in activities of daily living (LADL) among persons aged ≥80 years. The aim of this study was to estimate the determinants of LADL among persons aged ≥80 years based on 4‐wave national longitudinal data from Thailand.MethodsData from the Health, Aging and Retirement in Thailand study from 2015, 2017, 2020 and 2022 were utilized. The sample was restricted to community‐dwelling persons aged ≥80 years (analytic sample: n = 3113 observations). For the pooled sample, the average age was 85.4 years (range 80–117 years). Established measurements were used to assess LADL. Linear fixed effects regression was applied to assess the time‐varying determinants and outcomes.ResultsLinear fixed effects regressions showed that increasing age, an increase in the number of chronic conditions, an increase in depressive symptoms, higher religious involvement and being underweight increased LADL, whereas increases in exercise frequency and increases in subjective life expectancy decreased LADL. In addition, in subgroup analysis among 60–79‐year‐olds, transitioning to widowhood and work status decreased LADL. Further differences between ≥80‐year‐olds and 60–79‐year‐olds include that an increase in depressive symptoms and increase in chronic conditions only increased LADL among ≥80‐year‐olds and not among 60–79‐year‐olds.ConclusionsThis longitudinal study enhances our understanding of the determinants of LADL among persons aged ≥80 years. Strategies to delay or decrease depressive symptoms and chronic conditions, proper weight management and increasing physical activity might help in reducing LADL. Geriatr Gerontol Int 2025; ••: ••–••.
Toward a Comprehensive Understanding of Nurses' Compassion Fatigue: A Meta‐Integrative Qualitative Synthesis
Authors: Zhang Huiling , Dator Wireen Leila 
Published: January 2025

ABSTRACTAimsThe study aims to conduct a thematic synthesis approach of existing qualitative research to synthesise the real experiences of nurses dealing with compassion fatigue. This integration seeks to provide a comprehensive overview, identify common themes, and offer theoretical support for developing effective intervention strategies to mitigate compassion fatigue in healthcare settings.DesignA thematic synthesis approach was utilised, synthesising qualitative studies on nurses' experiences of compassion fatigue.Data SourcesData were collected from major academic databases, including PubMed, CINAHL, Scopus, and Web of Science. A total of 15 studies met the inclusion criteria.Review MethodsThis study systematically reviewed 11 qualitative research articles from China, the United States, Japan, Spain, Iran and Finland, involving 1076 nurses, to analyse and integrate the phenomenon of compassion fatigue among nurses and extract common themes.ResultsThe analysis revealed that the leading causes of compassion fatigue include insufficient time and resources, psychosocial stressors, compassion overload and organisational and environmental factors. The manifestations of compassion fatigue primarily consist of work‐related difficulties and impacts on family life, emotional and physical exhaustion and a mix of positive and negative emotions. Coping strategies focus on self‐care and emotional regulation, symptom recognition and response strategies and organisational interventions and training.ConclusionThis study's findings provide theoretical support for healthcare institutions to develop effective intervention strategies to alleviate compassion fatigue among nurses and improve the quality of care.ImpactThe study contributes to the body of knowledge by systematically synthesising qualitative evidence on compassion fatigue among nurses. The results have practical implications for nursing management and policy, emphasising the need for supportive measures to protect nurses from compassion fatigue and ensure sustainable care practices.Patient or Public ContributionThis research does not directly involve patients or public participants but focuses on synthesising the experiences of nurses as reported in existing studies, thereby indirectly contributing to improving patient care by addressing the well‐being of healthcare providers.
First Reports of Dual‐Chamber Leadless Pacemaker Implantation via Intrajugular Access
Authors: Suresh Sruthi Prabha , Buchanan Emily Boone , Yoo Dale 
Published: January 2025

ABSTRACTIntroductionThe Aveir Dual‐Chamber (DR) is the first entirely intracardiac dual‐chamber leadless pacing system. Implantation of this device is typically achieved via femoral access, which may be a significant obstacle in patients with complex femoral vasculature or contraindications to femoral access.Methods and ResultsThis report describes the world's first three cases of dual‐chamber leadless pacemaker implantation via the right internal jugular vein.ConclusionsThe intrajugular approach is a feasible, safe, and efficient alternative to femoral access for any patient receiving or upgrading to an Aveir DR.
Issues Related to Patient Participation in Psychiatric Hospital Care—An Integrative Literature Review of Patient Safety Research
Authors: Antikainen Reija , Turunen Hannele , Kuosmanen Anssi , Haatainen Kaisa 
Published: January 2025

ABSTRACTAimExplore how previous patient safety research has described issues related to patient participation in psychiatric hospital care.DesignIntegrated literature review.MethodsThe literature review was conducted according to Cooper's framework with the following five‐step protocol: problem identification, a literature search, data evaluation, data analysis, and the presentation of results.Data SourcesCINAHL, PubMed, PsycINFO, Scopus databases, years 2005–2023. After quality appraisal, a total of 62 articles were reviewed.ResultsThree main categories related to patient participation in psychiatric hospital care were identified: communication (having information, being heard, therapeutic relationships and interaction quality), decision‐making (treatment planning, treatment decisions, activities and working on behalf of patients) and restrictive measures (setting limits, exercising power, balancing patient autonomy and safety).ConclusionPsychiatric hospital care nursing staff continuously balance patients' autonomy, self‐determination, and safety, taking into account their well‐being and issues of responsibility. Wider use of positive risk‐taking is needed to increase patient participation and safety in psychiatric hospital care.Implications for the Profession and Patient CareNursing staff should create favourable facilities for patient participation, foster an atmosphere of trust, respect, and encouragement, provide patients individual time to improve patient safety and recognise that they can exert power over patients due to constantly balancing patient autonomy and safety.Reporting MethodPRISMA guidelines.Patient or Public ContributionNo patient or public contribution.
(Re)assessment of the COSMED Quark CPET and VO2Master Pro Systems for Measuring Pulmonary Gas Exchange and Ventilation
Authors: Thiessen Johan S. , Guluzade Nasimi A. , Faricier Robin , Keir Daniel A. 
Published: January 2025

ABSTRACTWe assessed the validity, reliability, and transferability of gas exchange and ventilatory variables from two commonly used metabolic measurement systems (COSMED Quark and VO2Master Pro). Two identical devices from each system were independently connected to a metabolic simulator (VacuMed), and 2 min of steady‐state data was recorded at simulated oxygen uptake (V̇O2) of 1, 2, 3, and 4 L∙min−1 achieved through minute ventilation (V̇E) of 30, 60, 105, and 150 L∙min−1. Each metabolic analyzer recorded data three times for each “intensity” in a randomized order, and assessments were completed on two separate days. Douglas bag‐based measurements were also made once at each simulated “intensity”. Measured steady‐state data (average of final 1.5 min) for both V̇O2 (STPD) and V̇E (ATPS) were compared with simulated values to assess validity, repeated values between and within days assessed reliability, and between‐device comparisons provided transferability. Including both COSMED devices at all intensities, the mean percent error for V̇O2 was 3.5% (range: −2.5%–8.1%) and, for V̇E, was 2.0% (−0.5%–7.6%). For the VO2Master, these values averaged 0.6% (−9.3%–4.8%) and 1.1% (−6.3%–4.0%) for V̇O2 and V̇E, respectively. Mean percent error for Douglas Bag was 1.5%, −3.7%, −3.1%, and −2.0% for 1, 2, 3, and 4 L∙min−1, respectively. Between‐day differences (reliability) for V̇O2 of both COSMED devices ranged from −4.1% to 2.2% (mean 0.1%) and, for both VO2Masters, between −1.6% and 11.1% (mean 1.2%). Between‐device differences (transferability) ranged from −3.5% to 0.5% (mean 1.3%) for COSMED and from −11.0% to 3.6% (mean 0.0%) for VO2Master. Mean values and ranges for V̇E were similar. When used appropriately in laboratory settings, the COSMED Quark and VO2Master Pro systems provide gas exchange and ventilatory data within an acceptable range for metabolic testing equipment that are both reliable and transferable between optimally performing devices.
Application of Syndromic Panels for respiratory Tract Infections in Lung Transplantation: A Critical Review on Current Evidence and Future Perspectives
Authors: Lombardi Andrea , Renisi Giulia , Liparoti Arianna , Bobbio Chiara , Bandera Alessandra 
Published: January 2025

ABSTRACTBackgroundInfections are a common complication among lung transplant recipients (LuTR), particularly in the first year post‐transplant, with respiratory tract infections (RTI) being predominant. Syndromic molecular panels have been suggested to reduce morbidity and mortality by providing a diagnosis quickly. However, integrating these panels into clinical practice remains debated.MethodsAn electronic search was conducted in PubMed, Scopus, and Embase to identify studies on applying syndromic panels for RTI diagnosis in LuTR. Three reviewers independently screened‐extracted data from relevant studies, focusing on concordance between syndromic panels and standard microbiologic tests and reporting isolates not detected by syndromic panels.ResultsFour studies met the inclusion criteria, including 308 patients. The BioFire FilmArray Pneumonia Panel was the syndromic panel most frequently employed. In three studies, the syndromic panel was employed in LuTR with suspected RTI or during routine surveillance bronchoalveolar lavage; only in one case was the syndromic panel employed during the transplant procedure on samples from the donor. Agreement between syndromic panels and standard tests ranged from 0.56 to 0.98, with result turnaround times between 2.3 and 21.2 h. Sensitivity ranged from 58% to 94%, and specificity from 78% to 100%. Pathogens outside syndromic panels targets but identified by standard tests included Candida spp., unspecified gram‐negative rods, and Aspergillus spp.ConclusionSyndromic panels offer a faster alternative to standard microbiologic tests. However, they miss numerous possible pathogens, highlighting the necessity for concurrent standard testing. Further research is needed to establish the most efficient integration of syndromic panels in LuTx infection diagnostic.
image
The complete genome of
Mycoplasmoides cavipharyngis
strain 117C, a close relative of hemotrophic mycoplasma
Authors: Kramer Janina , Zübert Christina , Huettel Bruno , Kube Michael , Hoelzle Ludwig E. 
Published: January 2025

ABSTRACT

Mycoplasmoides cavipharyngis
is one of the closest relatives of the highly host-adapted and uncultivable hemotrophic mycoplasma. The complete genome of strain 117C was constructed from long-reads derived from Pacific Biosciences single-molecule, real-time sequencing technology. The genome is organized into one circular, gapless chromosome with a length of 1,034 kb.
Abortion and unintended pregnancy in Pakistan: new evidence for 2023 and trends over the past decade
Authors: Sathar Zeba , Singh Susheela , Shah Iqbal H , Niazi Muhammad Rehan , Parveen Tahira , Mulhern Octavia , Mir Ali Mohammad 
Published: January 2025

BackgroundDespite induced abortion being highly legally restricted in Pakistan, studies in 2002 and 2012 showed that many women rely on abortion when faced with an unintended pregnancy. Following the 2012 study, concerted efforts were made to improve contraceptive services and to strengthen postabortion care. The availability and use of misoprostol also expanded in the past decade. Our primary objective was to provide new evidence on the rates of unintended pregnancy, induced abortion and postabortion care in 2023 and to assess trends in these outcomes since 2012.MethodsThis is a cross-sectional study based on a Health Professional Survey, and a nationally representative Health Facilities Survey, conducted in 2023. A widely applied methodology is used to estimate rates of abortion and unintended pregnancy. Data sources and methods are comparable across the 2012 and 2023 studies.ResultsIn 2023, an estimated six million unintended pregnancies occurred and 64% of them or 3.8 (95% CI 2.2 to 6.4) million resulted in induced abortions. This corresponds to an annual unintended pregnancy rate of 104 and an induced abortion rate of 66 (95% CI 38 to 111) per 1000 women aged 15–49. There was no significant change in the unintended pregnancy rate, but the abortion rate increased by 25% between 2012 and 2023. In 2023, 697 913 women were treated for postabortion complications, corresponding to an annual rate of 12.1 (95% CI 6.4 to 16.5) per 1000 women ages 15–49. This treatment rate declined by 16% between 2012 and 2023.ConclusionsThe unintended pregnancy rate has remained stable in the past decade. However, Pakistani women are increasingly relying on abortion to resolve unintended pregnancy. The treatment rate of postabortion complications has declined, owing largely to widespread access to misoprostol. This transformation of the abortion landscape calls for concerted efforts to increase contraceptive use and strengthen postabortion care.
Continuous individual feedback to nurses at emergency medical dispatch centres: a stepped-wedge, interrupted time series analysis
Authors: Spangler Douglas Nils , Blomberg Hans 
Published: January 2025

BackgroundClinical feedback is often lacking in prehospital care, and while performance data is increasingly available to clinical and operational leadership, it is seldom made available to care providers themselves. In this study, we investigate the impact of a simple intervention consisting of the provision of monthly feedback reports via email to emergency medical dispatch nurses in three Swedish regions.MethodIndividualised reports consisting of 14 measures divided into descriptive (eg, priority-setting and call times), process (eg, dispatch times and documentation completeness) and outcome (eg, over/under triage rate) categories were developed with staff and management input. Report delivery was implemented using a stepped-wedge design, and effects were evaluated using a hierarchical regression-based interrupted time series analysis.Results40 dispatchers were included in the study between March 2020 and October 2023, who handled a total of 246 353 incidents. Some impacts on documentation-related process measures were identified, with the odds of complete documentation increasing by 7.5% (95% CI 5.1 to 9.9) and the odds of having a documented contact reason increasing by 3.8% (1.5–5.9). These effects remained robust over the post-intervention period. Weaker impacts on outcome measures were identified which could be explained by a higher priority given to emergency medical dispatches overall.ConclusionProviding performance data can influence care providers to adjust their behaviour to improve process-related quality metrics under their direct control. The intervention may also have induced nurses to more often upgrade the priority of their patients. Improving outcome metrics may however require more intensive, multifaceted interventions.
Risk of long covid in patients with pre-existing chronic respiratory diseases: a systematic review and meta-analysis
Authors: Terry Paul , Heidel R Eric , Wilson Alexandria Q , Dhand Rajiv 
Published: January 2025

BackgroundAn estimated 10–30% of people with COVID-19 experience debilitating long-term symptoms or long covid. Underlying health conditions associated with chronic inflammation may increase the risk of long covid.MethodsWe conducted a systematic review and meta-analysis to examine whether long covid risk was altered by pre-existing asthma or chronic obstructive pulmonary disease (COPD) in adults. We identified studies by searching the PubMed and Embase databases from inception to 13 September 2024. We excluded studies that focused on children or defined long covid only in terms of respiratory symptoms. We used random-effects, restricted maximum likelihood models to analyse data pooled from 51 studies, which included 43 analyses of asthma and 30 analyses of COPD. The risk of bias was assessed using a ROBINS-E table.ResultsWe found 41% increased odds of long covid with pre-existing asthma (95% CI 1.29 to 1.54); pre-existing COPD was associated with 32% increased odds (95% CI 1.16 to 1.51). Pre-existing asthma, but not COPD, was associated with increased odds of long covid-associated fatigue. We observed heterogeneity in the results of studies of asthma related to hospitalisation status. Potential confounding and inconsistent measurement of exposure and outcome variables were among the identified limitations.ConclusionsOur findings support the hypothesis that pre-existing asthma and COPD increase the risk of long covid, including chronic fatigue outcomes in patients with asthma. Because COVID-19 targets the respiratory tract, these inflammatory conditions of the lower respiratory tract could provide mechanistic clues to a common pathway for the development of long-term sequelae in patients with long covid.