bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin disease
Authors: Kommoss Katharina S. , Bieler Tabea , Ringen Julia , Lehmann Annika , Mihalceanu Silvia , Hobohm Lukas , Keller Karsten , Brand Anna , Fischer Berenice , Kramer Daniela , Wild Johannes , Waisman Ari , Enk Alexander , Schäkel Knut , Heikenwälder Mathias , Karbach Susanne 
Published: December 2023

Abstract
Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well as preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in psoriasis patients and five murine models of psoriasis-like skin disease based on topical imiquimod application and overexpression of IL-17A under different promotors. We performed a single-center prospective observational study in a German population, investigating psoriasis patients prior to, 4 weeks, and 16 weeks post begin of systemic anti-inflammatory therapy. Psoriasis area and severity index (PASI), blood count, and C-reactive protein (CRP) levels were attained at each timepoint. Additionally, five murine models of psoriasis-like skin disease involving five distinct experimental procedures differing in time of disease-onset and severity were investigated regarding PLR and NLR. Of 43 recruited psoriasis patients, 34 patients were followed up to 16 weeks. The cohort was 69.77% male, showing a median age of 32.0 years (range 19.0–67.0; IQR 26). The median PASI decreased from 16.35 (8.0–50.0; 10.20) to 1.6 (0–10.3; 2.56) after 16 weeks of systemic therapy. Spearman’s correlation showed statistically significant positive correlation for NLR with PASI (rs = 0.27, p = 0.006), however not for PLR. NLR, but not PLR, was significantly associated with PASI in a multiple linear regression analysis including age, sex, psoriasis arthritis, and smoking. In the murine models of psoriasis-like skin disease, both NLR and PLR were significantly increased in the acute-severe models compared to controls (p < 0.001, p = 0.005, and p = 0.02, respectively), demonstrating gradually less increased values from severe-acute to mild-late-onset psoriatic phenotype. NLR was significantly associated with PASI in psoriatic patients as well as psoriatic phenotype in different murine psoriasis models. Our data warrants investigation of NLR in psoriasis patients and preclinical psoriasis models as an objective biomarker of psoriatic skin inflammation.

Key messages

NLR, but not PLR, showed a statistically significant positive correlation with Psoriasis Area and Severity Index (PASI) in our human psoriasis cohort.

Both NLR and PLR were significantly increased in murine psoriasis models compared to matched controls, with gradually less increased values from severe-acute to mild-late-onset psoriatic phenotype.

NLR may represent an easily available, cheap, and objective parameter to monitor psoriatic inflammation in both clinical patient routine, as well as preclinical experimental murine models.
Mineralocorticoid receptor overactivation: targeting systemic impact with non-steroidal mineralocorticoid receptor antagonists
Authors: Savarese Gianluigi , Lindberg Felix , Filippatos Gerasimos , Butler Javed , Anker Stefan D. 
Published: December 2023

AbstractThe overactivation of the mineralocorticoid receptor (MR) promotes pathophysiological processes related to multiple physiological systems, including the heart, vasculature, adipose tissue and kidneys. The inhibition of the MR with classical MR antagonists (MRA) has successfully improved outcomes most evidently in heart failure. However, real and perceived risk of side effects and limited tolerability associated with classical MRA have represented barriers to implementing MRA in settings where they have been already proven efficacious (heart failure with reduced ejection fraction) and studying their potential role in settings where they might be beneficial but where risk of safety events is perceived to be higher (renal disease). Novel non-steroidal MRA have distinct properties that might translate into favourable clinical effects and better safety profiles as compared with MRA currently used in clinical practice. Randomised trials have shown benefits of non-steroidal MRA in a range of clinical contexts, including diabetic kidney disease, hypertension and heart failure. This review provides an overview of the literature on the systemic impact of MR overactivation across organ systems. Moreover, we summarise the evidence from preclinical studies and clinical trials that have set the stage for a potential new paradigm of MR antagonism.
Graphical Abstract
Optimisation of process parameters for improving surface quality in laser powder bed fusion
Authors: Qin Yuchu , Lou Shan , Shi Peizhi , Qi Qunfen , Zeng Wenhan , Scott Paul J. , Jiang Xiangqian 
Published: December 2023

AbstractSurface quality is one of the critical factors that affect the performance of a laser powder bed fusion part. Optimising process parameters in process design is an important way to improve surface quality. So far, a number of optimisation methods have been presented within academia. Each of these methods can work well in its specific context. But they were established on a few special surfaces and may not be capable to produce satisfying results for an arbitrary part. Besides, they do not consider the simultaneous improvement of the quality of multiple critical surfaces of a part. In this paper, an approach for optimising process parameters to improve the surface quality of laser powder bed fusion parts is proposed. Firstly, Taguchi optimisation is performed to generate a small number of alternative combinations of the process parameters to be optimised. Then, actual build and measurement experiments are conducted to obtain the quality indicator values of a certain number of critical surfaces under each alternative combination. After that, a flexible three-way technique for order of preference by similarity to ideal solution is used to determine the optimal combination of process parameters from the generated alternatives. Finally, a case study is presented to demonstrate the proposed approach. The demonstration results show that the proposed approach only needs a small amount of experimental data and takes into account the simultaneous improvement of the quality of multiple critical surfaces of an arbitrary part.
Functionality of the Na+-translocating NADH:quinone oxidoreductase and quinol:fumarate reductase from Prevotella bryantii inferred from homology modeling
Authors: Hau Jann-Louis , Schleicher Lena , Herdan Sebastian , Simon Jörg , Seifert Jana , Fritz Günter , Steuber Julia 
Published: December 2023

AbstractMembers of the family Prevotellaceae are Gram-negative, obligate anaerobic bacteria found in animal and human microbiota. In Prevotella bryantii, the Na+-translocating NADH:quinone oxidoreductase (NQR) and quinol:fumarate reductase (QFR) interact using menaquinone as electron carrier, catalyzing NADH:fumarate oxidoreduction. P. bryantii NQR establishes a sodium-motive force, whereas P. bryantii QFR does not contribute to membrane energization. To elucidate the possible mode of function, we present 3D structural models of NQR and QFR from P. bryantii to predict cofactor-binding sites, electron transfer routes and interaction with substrates. Molecular docking reveals the proposed mode of menaquinone binding to the quinone site of subunit NqrB of P. bryantii NQR. A comparison of the 3D model of P. bryantii QFR with experimentally determined structures suggests alternative pathways for transmembrane proton transport in this type of QFR. Our findings are relevant for NADH-dependent succinate formation in anaerobic bacteria which operate both NQR and QFR.
Reduction of malic acid in bilberry juice by Lactiplantibacillus plantarum-mediated malolactic fermentation
Authors: Bergentall Martina K. , Malafronte Loredana , As Dorine , Calmet Emeline , Melin Petter 
Published: December 2023

AbstractBilberries (Vaccinium myrtillus) are the most common wild berries in Northern Europe. A substantial amount of the berries are picked with the objective to extract highly valued products such as anthocyanins. A smaller amount of the bilberries is used to make jams and drinks, and these are generally restricted to the domestic market. One reason is the sour taste, partly as a result of the high content of malic acid. By using certain strains of lactic acid bacteria with the ability to convert malic acid to lactic acid, the taste is predicted to be more pleasant. This process is called malolactic fermentation, and historically it has mostly been used in winemaking. After testing five different starter cultures, we identified that the strain, Lactiplantibacillus plantarum LP58, can rapidly convert malic acid to lactic acid without any loss of sugar or citric acid, which strongly indicates a successful malolactic acid fermentation. As it has been reported that other strains of L. plantarum can be used as biopreservative agents, the resulting product was also tested in terms of microbial safety after prolonged storage, and by means of metagenome sequencing. The obtained product was quite tolerant to microbial growth, but this observation was rather due to an initial heat treatment than the addition of lactobacilli. Potentially, starter cultures with documented biopreservative activity can be combined with L. plantarum LP58 to obtain a more stable product. Until then, the fermented bilberry juice must be processed and preserved like non-fermented bilberry products.
Quick, Safe, Effective: Ultrasound-Guided Percutaneous Liver Biopsy in the Pediatric Patient
Authors: Salamo Russell M. , Miller Joseph 
Published: December 2023

Abstract
Background
Percutaneous liver biopsy has proven to be a valuable tool in the workup of pediatric acute liver failure and the management of post-transplant rejection. However, consensus regarding pre-procedure laboratory values and post-procedure monitoring is lacking.

Objective
To characterize the incidence of complications, procedural time, and specimen adequacy for percutaneous liver biopsy in the pediatric patient.

Methods
Retrospective review of percutaneous liver biopsies at a single institution was performed for a 5-year span. Procedural notes and anesthesia records were sampled for patient weight and procedural factors across a continuous 6-month period, as well as for the subgroup of patients under 24 months of age. A representative continuous subset of pathology reports comprising 376 patients were reviewed for estimation of specimen adequacy.

Results
Eight hundred and sixty-seven ultrasound-guided percutaneous liver biopsies were performed in a 5-year period, 450 of which were in the post-transplant setting with about a 3:1 ratio of split: whole liver transplant. Patient ages ranged from 1 month to 21 years old, with weight ranging from 2.7 to 125 kg. Of the 376 pathology reports available, none were found to be inadequate for evaluation. Two major complications occurred, both of which were biliary leaks in the setting split-liver transplant. There were no incidences of post-procedure hemorrhage. Of the sample reviewed, mean “skin-to-skin” procedure time was under 8.5 min (median of 7 min). Solely among transplant patients, biopsies for split livers averaged 9.2 min, biopsies for whole livers averaged 6.2 min (two-tailed independent t test, p = 0.0426).

Conclusion
Ultrasound guided percutaneous liver biopsy is fast, useful, and safe in pediatric patients on an outpatient basis with same day discharge.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Evidence mapping on how to perform an optimal surgical repair of large hiatal hernias
Authors: Nickel Felix , Müller Philip C. , Cizmic Amila , Häberle Frida , Muller Markus K. , Billeter Adrian T. , Linke Georg R. , Mann Oliver , Hackert Thilo , Gutschow Christian A. , Müller-Stich Beat P. 
Published: December 2023

Abstract
Background
Symptomatic and large hiatal hernia (HH) is a common disorder requiring surgical management. However, there is a lack of systematic, evidence-based recommendations summarizing recent reviews on surgical treatment of symptomatic HH. Therefore, this systematic review aimed to create evidence mapping on the key technical issues of HH repair based on the highest available evidence.

Methods
A systematic review identified studies on eight key issues of large symptomatic HH repair. The literature was screened for the highest level of evidence (LE from level 1 to 5) according to the Oxford Center for evidence-based medicine’s scale. For each topic, only studies of the highest available level of evidence were considered.

Results
Out of the 28.783 studies matching the keyword algorithm, 47 were considered. The following recommendations could be deduced: minimally invasive surgery is the recommended approach (LE 1a); a complete hernia sac dissection should be considered (LE 3b); extensive division of short gastric vessels cannot be recommended; however, limited dissection of the most upper vessels may be helpful for a floppy fundoplication (LE 1a); vagus nerve should be preserved (LE 3b); a dorso-ventral cruroplasty is recommended (LE 1b); routine fundoplication should be considered to prevent postoperative gastroesophageal reflux (LE 2b); posterior partial fundoplication should be favored over other forms of fundoplication (LE 1a); mesh augmentation is indicated in large HH with paraesophageal involvement (LE 1a).

Conclusion
The current evidence mapping is a reasonable instrument based on the best evidence available to guide surgeons in determining optimal symptomatic and large HH repair.
Therapeutische Eigenanteile in der Gegenübertragung
Authors: Berger J. A. , Kästner D. , Gumz A. 
Published: December 2023

ZusammenfassungGegenübertragung (GÜ) gilt mittlerweile als eines der wichtigsten Werkzeuge psychodynamischer Verfahren. Während die interpersonellen Muster des/r Patient:in, die sich in dieser wiederfinden, praktisch und theoretisch vielfach beachtet werden, ist noch wenig über die Eigenanteile des/r Therapeut:in in der GÜ bekannt. Eine Schwierigkeit in der Beforschung dieser besteht in der Erfassung eines Phänomens, das viele Forscher:innen als ich-synton und damit unbewusst begreifen. Eine Annäherung an das Thema erfolgte bisher überwiegend durch Fallberichte klinisch tätiger Autor:innen. Der vorliegende Beitrag bietet einen Überblick über die bisherige empirische Forschung zu dem Thema.Die systematische Suche erfolgte über die elektronischen Datenbanken PsycINFO, PsycArticles, PubMed und PSYNDEX und bezog nach Titel- und Abstractscreening von 1037 Studien schließlich 10 Publikationen in die Auswertung ein. Dabei wurde deutlich, dass die eingeschlossenen Studien sowohl hinsichtlich der zugrunde liegenden Definitionen von Eigenanteil und GÜ sowie der Versuche, diese messbar zu machen, stark divergieren.Um Eigenanteile im Kontext des GÜ-Geschehens zu erfassen, wird eine Erweiterung des Konzeptes von Hayes vorgeschlagen, das folgende Therapeut:innenanteile integriert: Persönlichkeitseigenschaften und Einstellungen, soziodemografische Merkmale und biografische Erfahrungen (subjektive Einschätzungen versus objektive Informationen).
Kidney biopsy findings in children with diabetes mellitus
Authors: Weerasooriya Lasanthi , Howie Alexander J. , Wakeman Matthew P. , Cavanagh Susan , Milford David V. 
Published: December 2023

Abstract
Background
Diabetic nephropathy may begin in childhood, but clinical kidney disease ascribable to this is uncommon in children with type 1 (insulin dependent) diabetes mellitus.

Methods
We reviewed our experience of kidney biopsies in children with type 1 diabetes mellitus.

Results
Between 1995 and 2022, there were biopsies in 17 children, with various clinical indications for kidney biopsy, making this the largest series of biopsies in diabetic children with clinical kidney abnormalities. Four biopsies showed diabetic nephropathy, three showed the combination of diabetic nephropathy and IgA nephropathy, and ten showed a variety of conditions other than diabetic nephropathy: minimal change disease (2), membranous nephropathy (2), thin glomerular basement membrane lesion (2), non-glomerular chronic damage in Wolcott–Rallison syndrome (2), acute pauciimmune necrotizing crescentic glomerulonephritis (1) and IgA nephropathy (1). Clinical clues of something other than diabetic nephropathy included acute kidney injury, microscopic haematuria or chronic kidney impairment with little or no proteinuria and the nephrotic syndrome after a short duration of diabetes.

Conclusions
We confirm that changes better known in adults with either type 1 or type 2 diabetes mellitus can occur in children with type 1 diabetes mellitus: overt diabetic nephropathy either on its own or combined with other conditions and kidney disorders other than diabetic nephropathy.

Graphical abstract
2023 updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following high-emetic-risk antineoplastic agents
Authors: Herrstedt Jørn , Celio L , Hesketh PJ , Zhang L , Navari R , Chan A , Saito M , Chow R , Aapro M 
Published: December 2023

Abstract
Purpose
This systematic review updates the MASCC/ESMO recommendations for high-emetic-risk chemotherapy (HEC) published in 2016–2017. HEC still includes cisplatin, carmustine, dacarbazine, mechlorethamine, streptozocin, and cyclophosphamide in doses of > 1500 mg/m2 and the combination of cyclophosphamide and an anthracycline (AC) in women with breast cancer.

Methods
A systematic review report following the PRISMA guidelines of the literature from January 1, 2015, until February 1, 2023, was performed. PubMed (Ovid), Scopus (Google), and the Cochrane Database of Systematic Reviews were searched. The literature search was limited to randomized controlled trials, systematic reviews, and meta-analyses.

Results
Forty-six new references were determined to be relevant. The main topics identified were (1) steroid-sparing regimens, (2) olanzapine-containing regimens, and (3) other issues such as comparisons of antiemetics of the same drug class, intravenous NK1 receptor antagonists, and potentially new antiemetics. Five updated recommendations are presented.

Conclusion
There is no need to prescribe steroids (dexamethasone) beyond day 1 after AC HEC, whereas a 4-day regimen is recommended in non-AC HEC. Olanzapine is now recommended as a fixed part of a four-drug prophylactic antiemetic regimen in both non-AC and AC HEC. No major differences between 5-HT3 receptor antagonists or between NK1 receptor antagonists were identified. No new antiemetic agents qualified for inclusion in the updated recommendations.
Locally harmonic Maass forms of positive even weight
Authors: Mono Andreas 
Published: December 2023

AbstractWe twist Zagier’s function fk,D by a sign function and a genus character. Assuming weight 0 < k ≡ 2 (mod 4), and letting D be a positive non-square discriminant, we prove that the obstruction to modularity caused by the sign function can be corrected obtaining a locally harmonic Maaß form or a local cusp form of the same weight. In addition, we provide an alternative representation of our new function in terms of a twisted trace of modular cycle integrals of a Poincaré series due to Petersson.
On the packing/covering conjecture of infinite matroids
Authors: Joó Attila 
Published: December 2023

AbstractThe Packing/Covering Conjecture was introduced by Bowler and Carmesin motivated by the Matroid Partition Theorem of Edmonds and Fulkerson. A packing for a family $$({M_i}:i \in \Theta)$$
(

M
i

:
i
∈
Θ
)
of matroids on the common edge set E is a system $$({S_i}:i \in \Theta)$$
(

S
i

:
i
∈
Θ
)
of pairwise disjoint subsets of E where Si is panning in Mi. Similarly, a covering is a system (Ii: i ∈ Θ) with $${\cup _{i \in \Theta}}{I_i} = E$$

∪

i
∈
Θ

I
i

=
E
where Ii is independent in Mi. The conjecture states that for every matroid family on E there is a partition $$E = {E_p} \sqcup {E_c}$$
E
=

E
p

⊔

E
c

such that $$({M_i}\upharpoonright{E_p}:i \in \Theta)$$
(

M
i

↾

E
p

:
i
∈
Θ
)
admits a packing and $$({M_i}.{E_c}:i \in \Theta)$$
(

M
i

.

E
c

:
i
∈
Θ
)
admits a covering. We prove the case where E is countable and each Mi is either finitary or cofinitary. To do so, we give a common generalisation of the singular matroid intersection theorem of Ghaderi and the countable case of the Matroid Intersection Conjecture by Nash-Williams by showing that the conjecture holds for countable matroids having only finitary and cofinitary components.
An examination of auxetic componentry for applications in human-centred biomedical product design settings
Authors: Urquhart Lewis , Tamburrino Francesco , Neri Paolo , Wodehouse Andrew , Fingland Craig , Razionale Armando Viviano 
Published: December 2023

AbstractThis paper explores how the examination of additively manufactured auxetic componentry can be applied in human-centred design settings with particular focus on biomedical products. Firstly, the design applications of auxetics are detailed followed by a review of the key problems facing practical researchers in the field with the treatment of boundary conditions identified as a key issue. The testing setup that is then introduced utilises a novel method of part mounting and facilitates optical analysis and real-time force–displacement measurements. A study is advanced that analyses three different auxetic structures (re-entrant, chiral, and semi-rigid), a set of samples of which were additively manufactured in flexible TPU material. A range of parameters were varied across the three designs including interior geometry and wall thicknesses in order to demonstrate the effectiveness of the setup for the examination of the different structures. The results from these examinations are subsequently discussed and a number of suggestions made regarding how this kind of analysis may be integrated into novel design development workflows for achieving human-centred biomedical devices which often require detailed consideration of ergonomic and usability factors.
Volatile Organic Compounds Detected in Amniotic Fluid of Women During Normal Pregnancy
Authors: Minet-Quinard Régine , Goncalves-Mendes Nicolas , Gallot Denis , Pereira Bruno , Lambert Celine , Brailova Marina , Blanchon Loic , Bouvier Damien , Sapin Vincent 
Published: December 2023

AbstractExposure to volatile organic compounds (VOCs) during the fetal period may induce negative effects on children’s health (e.g. increased risk of low birth weight and imbalanced development). Whereas VOCs have been analysed extensively in various human biological fluids (i.e. urine, blood, and breath), during pregnancy only urine has been studied and no work has been performed on amniotic fluid (AF), which is in direct contact with the fetus and is essential for its well-balanced development and maturation. This study aimed to detect VOCs in AF and to investigate their links to the lifestyle habits of pregnant women. The VOC composition of the AF collected from 76 healthy pregnant women was analysed using a gas chromatograph coupled to a mass spectrometer. The sources of VOC exposure in pregnant women were assessed using a questionnaire about their home living conditions and their professional exposure. A total of 126 VOCs belonging to 13 chemical families were detected in AF. The majority of these VOCs (92) had an exogenous origin, and their presence was linked to lifestyle habits, especially smoking and fragrance use. Considering the direct contact of these VOCs with multiple fetal organs, this study is an important contribution to the literature exploring the future potential relationships between VOCs and abnormal fetal development.