bluuebunny/crossref_metadata_2025_split huggingface dataset:
City‐scale assessment of the material and environmental footprint of buildings using an advanced building information model: A case study from Canberra, Australia
Authors: Soonsawad Natthanij , Marcos‐Martinez Raymundo , Schandl Heinz 
Published: January 2024

AbstractAs cities grow, demand for urban materials is set to rise. Meeting sustainability targets will require transformative changes to how cities are constructed. Yet, accurate information on embodied building materials and their environmental impacts at the city scale is still lacking. We use Light Detection and Ranging data, building archetype information, and statistical models to estimate the embodied materials in buildings in Canberra, Australia, and their energy, carbon, and water footprint. In 2015, 57 million tonnes (Mt) of materials were embodied in 140,805 buildings. By weight, concrete was the most used material (44%), followed by sand and stone (32%), and ceramics (11%). Current population growth and building construction trends indicate a need for 2.4 times the building materials stock of 2015 by 2060. Producing such materials would require 1.6 thousand TJ of energy and 793 thousand megaliters of water and emit 48 Mt of CO2e—an environmental footprint 1.6 times the one in 2015. If the additional population were to live only in new single houses, material demand would be 4% higher than under current trends and the environmental footprint 5% higher. Housing new residents in low‐rise apartments would reduce from current trends the material demand by 5% and the environmental footprint by 12%. Using only apartments of four or more stories would reduce material demand by 28% and the environmental footprint by 14%. This research can inform circular economy efforts to improve building materials management by helping estimate the implications of alternative configurations of the urban built environment.
Categorization of manufacturing companies’ readiness profiles for the transition to the circular economy: A multidimensional cluster analysis
Authors: Zomer Thayla , McAloone Tim , Pigosso Daniela 
Published: January 2024

AbstractThe circular economy (CE) field has moved from purely conceptual research into empirical studies. However, the literature does not provide generalized conclusions regarding the overall state of CE transition in manufacturing companies. Existing studies lack a perspective in explaining differences among companies planning or already transitioning to the CE because most empirical research so far is based on single or few case studies, generally assuming that the transition to CE, once undertaken as a purpose, moves along a continuum from a linear model to a circular one. This paper identifies differences among manufacturing companies planning and transitioning to CE and conceptualizes readiness profiles along eight dimensions of change identified in the literature as essential to CE implementation in organizations. A cluster analysis of a sample of manufacturing companies from different sectors, sizes, and locations identified five readiness profiles: the laggards, the explorers, the frontrunners, the strategizers, and the information oriented. The results show that companies may follow different approaches when exploring the potential of CE in their businesses. While some companies decide to explore and experiment across all dimensions of change, others follow a more strategic or operational approach, suggesting different states in which companies find themselves. The findings offer evidence of the change happening across the manufacturing industry and how CE transition unfolds in practice, extending existing literature by providing more overall conclusions on how the transition might unfold in manufacturing companies and different states that companies might be regarding the multiple dimensions of change that should be considered.
Determinacy and E‐Stability with Interest Rate Rules at the Zero Lower Bound
Authors: EO YUNJONG , MCCLUNG NIGEL 
Published: January 2024

AbstractWe evaluate and compare alternative interest rate rules, namely, average inflation targeting (AIT), price‐level targeting (PLT), and traditional inflation targeting rules, in a standard New Keynesian model that features recurring, transient zero lower bound regimes. We use determinacy and expectational stability (E‐stability) of equilibrium as the criteria for stabilization policy. We find that PLT policy, including nominal GDP targeting as a special case, most effectively promotes determinacy and E‐stability among the policy frameworks, whereas standard inflation targeting rules are prone to indeterminacy. AIT can induce determinacy and E‐stability effectively, provided the averaging window is sufficiently long.
Investigator‐blinded, controlled, and randomized comparative study on 1565 nm non‐ablative fractional laser versus 5% minoxidil for treatment of androgenetic alopecia
Authors: Qu Huanhuan , Zhang Rongli , Xin Wuyan , Jing Huan , Wang Gang , Gao Lin 
Published: January 2024

AbstractBackgroundCharacterized by progressive hair loss due to an excessive response to androgens, androgenetic alopecia (AGA) affects up to 50% of males and females. Minoxidil is one of approved medications for AGA but inadequate responses occur in many patients.AimsTo determine whether 1565 nm non‐ablative fractional laser (NAFL) could yield better therapeutic benefits for patients with AGA as compared with 5% minoxidil.MethodsThirty patients with AGA were enrolled; they were randomly assigned into the laser or minoxidil treatment groups. For the laser treatment group, patients were treated by 1565 nm NAFL at 10 mJ, 250 spots/cm2 with 2 weeks intervals for 4 sessions in total. For the minoxidil treatment group, 1‐milliliter of topical 5% minoxidil solution was applied to hair loss area twice a day.ResultsThe primary outcomes were the changes in numerous hair growth indexes at the Week 10 as compared with the baselines. Both 1565 nm NAFL and 5% minoxidil led to significantly greater hair densities and diameters in patients at the Week 10 than the baselines (p < 0.01). As compared with 5% minoxidil, 1565 nm NAFL showed significantly greater improvements in total hair number, total hair density (hair/cm2), terminal hair number, terminal hair density (hair/cm2), number of hair follicle units, and average hair number/number of hair follicle units.ConclusionsOur data demonstrate that 1565 nm NAFL exhibits superior clinical efficacy in some aspects of hair growth to the topical minoxidil. It is a safe and effective modality in treating AGA.
Sleep–wake state discrepancy does not impair the efficacy of cognitive behavioural therapy for insomnia: Findings from a large clinic sample
Authors: Moulder Zoe , Sweetman Alexander , Lovato Nicole , Micic Gorica , Lack Leon , Scott Hannah 
Published: January 2024

SummaryThe current study determined the extent to which sleep–wake state discrepancy impairs the efficacy of cognitive behavioural therapy for insomnia in a real‐world clinical sample. Sleep–wake state discrepancy occurs when there is an inconsistency between a person's subjective and objective sleep, and is a common phenomenon amongst patients with insomnia. Limited information is available on the effectiveness of cognitive behavioural therapy for insomnia in treating patients who experience significant sleep–wake state discrepancy in “real‐world” samples. In the present study, all patients with insomnia received cognitive behavioural therapy for insomnia through an outpatient insomnia program (N = 386; mean age = 51.96 years, SD = 15.62; 65.97% [N = 254] female). Prior to treatment, participants completed a polysomnography sleep study and sleep diary, which was used to calculate sleep–wake state discrepancy. At pre‐treatment, post‐treatment and 3‐month follow‐up, participants completed the Insomnia Severity Index and other questionnaires, and 1 week of sleep diaries from which sleep‐onset latency, wake after sleep onset and other sleep variables were calculated. There were no differences in self‐reported sleep‐onset latency, wake after sleep onset or Insomnia Severity Index scores at post‐treatment or 3‐month follow‐up between quintiles of sleep–wake state discrepancy. These results indicate that sleep–wake state discrepancy at pre‐treatment does not predict treatment response to cognitive behavioural therapy for insomnia. Future research could examine multi‐night assessments of sleep–wake state discrepancy to determine whether variations in discrepancy may relate to pre‐treatment insomnia severity and cognitive behavioural therapy for insomnia outcomes.
Strewn field, mineralogy, and petrology of Al Haggounia 001: A unique enstatite chondrite
Authors: Leili M. H. , Chennaoui Aoudjehane H. , Devouard B. , Rochette P. , Gattacceca J. , Folco L. , Gemelli M. , Baziotis I. 
Published: January 2024

AbstractIn this work, we investigate macroscopic characteristics, magnetic susceptibility, mineralogy, and mineral composition of Al Haggounia 001. The samples were collected during eight field missions in the period between 2015 and 2019. In the strewn field of about 65 km in length, the specimens are found either on the surface or shallowly buried in loose sediments, which rules out the previous suggestions that this meteorite is a fossil meteorite. Macroscopically, the samples exhibit three major lithologies with various colors, porosities, and distributions of oxidized veins. The data obtained using transmitted and reflected light microscopy, scanning electron microscopy, and electron microprobe analysis confirm the macroscopic observations and show a heterogenous distribution of silicates and metal sulfides. Al Haggounia 001 is composed of enstatite, plagioclase, kamacite, taenite, schreibersite, daubreelite, troilite, graphite, sinoite, and silica polymorphs. We identified a new type of chondrules that are flattened and composed of rods of albite and enstatite, as well as elongated nodules of metal and sulfides, in addition to compression fractures in the form of subparallel veinlets. These features presumably reflect the deformation caused by shock. The magnetic susceptibility of Al Haggounia 001 (4.39 ± 0.20) is much lower than that of usual EH (5.48 ± 0.16) and EL (5.46 ± 0.04) chondrites but is in the range of E finds (5.05 ± 0.43). The thermomagnetic and hysteresis measurements are controlled by type, size, distribution of metal‐sulfide nodules, arrangement of oxyhydroxide veins, and weathering. Al Haggounia 001 is an anomalous meteorite with a polymict nature. It records multiple events revealing its unique origin which expends the groups of enstatite chondrites and provides insights into the complex formation and evolution history of their parent body.
The genomic consequences of selection across development
Authors: James Maddie E. , Ortiz‐Barrientos Daniel 
Published: January 2024

Understanding how natural selection drives diversification in nature has been at the forefront of biological research for over a century. The main idea is simple: natural selection favours individuals best suited to pass on their genes. However, the journey from birth to reproduction is complex as organisms experience multiple developmental stages, each influenced by genetic and environmental factors (Orr, 2009). These complexities compound even further as each stage of development might be governed by a unique underlying set of alleles and genes. In this issue of Molecular Ecology, Goebl et al. (2022) examine the role of natural selection in driving ecotypic divergence across different life history stages of the prairie sunflower Helianthus petiolaris. The authors used reciprocal transplant experiments, demographic models, and genomic sequencing to explore fitness variation across developmental stages. They show how natural selection impacts population divergence across multiple life history stages and evaluate the resulting allele frequency changes. Goebl et al. link these results to the role of chromosomal inversions, thus furthering our understanding of how ecological divergence proceeds in the face of gene flow. Below, we explore these results in detail and complement their interpretation by considering the evolution of genetic correlations amongst traits governing fitness.
Skin innate immune response against fungal infections and the potential role of trained immunity
Authors: Bombassaro Amanda , Figueiredo Julia Marcondes , Taborda Carlos P. , Joosten Leo A. B. , Vicente Vania A. , Queiroz‐Telles Flavio , Meis Jacques F. , Kischkel Brenda 
Published: January 2024

AbstractFungal skin infections are distributed worldwide and can be associated with economic and social traits. The immune response related to skin cells is complex and its understanding is essential to the comprehension of each cell's role and the discovery of treatment alternatives. The first studies of trained immunity (TI) described the ability of monocytes, macrophages and natural killer (NK) cells to develop a memory‐like response. However, the duration of TI does not reflect the shorter lifespan of these cells. These conclusions supported later studies showing that TI can be observed in stem and haematopoietic cells and, more recently, also in non‐immune skin cells such as fibroblasts, highlighting the importance of resident cells in response to skin disorders. Besides, the participation of less studied proinflammatory cytokines in the skin immune response, such as IL‐36γ, shed light into a new possibility of inflammatory pathway blockade by drugs. In this review, we will discuss the skin immune response associated with fungal infections, the role of TI in skin and clinical evidence supporting opportunities and challenges of TI and other inflammatory responses in the pathogenesis of fungal skin infections.
Novel ultrasound‐guided supraclavicular stellate ganglion block
Authors: Fajardo Pérez Mario , Yamak‐Altinpulluk Ece , Díez Tafur Rodrigo , Salazar‐Zamorano Carlos H. , Espinosa Morales Karla , Oliver‐Fornies Pablo , Rocha‐Romero Andrés , Aguilar Ureña Ricardo , Juarez‐Lemus Angel , Galluccio Felice , Abd‐Elsayed Alaa 
Published: January 2024

AbstractIntroductionStellate ganglion block (SGB) provides diagnostic and therapeutic benefits in pain syndromes in the head, neck, and upper extremity, including complex regional pain syndrome Types I and II, Raynaud's disease, hyperhidrosis, arterial embolism in the region of the arm.MethodsWe present a novel ultrasound‐guided supraclavicular stellate ganglion block. Considering the existing anatomical structures of the targeted area.Results and ConclusionsWe hope that we can provide fewer complications and additional benefits with this new approach.
The transcription factor OsbZIP48 governs rice responses to zinc deficiency
Authors: Hu Shubao , Du Binbin , Mu Guangmao , Jiang Zichen , Li Hui , Song Yuxinrui , Zhang Baolei , Xia Jixing , Rouached Hatem , Zheng Luqing 
Published: January 2024

AbstractZinc (Zn) deficiency is the most prevalent micronutrient disorder in rice and leads to delayed development and decreased yield. Nevertheless, despite its primary importance, how rice responds to Zn deficiency remains poorly understood. This study presents genetic evidence supporting the crucial role of OsbZIP48 in regulating rice's response to Zn deficiency, consistent with earlier findings in the model plant Arabidopsis. Genetic inactivation of OsbZIP48 in rice seedlings resulted in heightened sensitivity to Zn deficiency and reduced Zn translocation from roots to shoots. Consistently, OsbZIP48 was constitutively expressed in roots, slightly induced by Zn deficiency in shoots and localized into nuclei induced by Zn deficiency. Comparative transcriptome analysis of the wild‐type plants and osbzip48 mutant grown under Zn deficiency enabled the identification of OsbZIP48 target genes, including key Zn transporter genes (OsZIP4 and OsZIP8). We demonstrated that OsbZIP48 controlled the expressions of these genes by directly binding to their promoters, specifically to the Zn deficiency response element motif. This study establishes OsbZIP48 as a critical transcription factor in rice's response to Zn deficiency, offering valuable insights for developing Zn‐biofortified rice varieties to combat global Zn limitation.
Volatile organic compounds as potential biomarkers of Cadophora luteo‐olivacea presence on kiwifruits
Authors: Di Francesco Alessandra , Reddi Giorgia , Moret Erica , Cignola Rudy , Ermacora Paolo 
Published: January 2024

AbstractCadophora luteo‐olivacea is the causal agent of the skin‐pitting disease of kiwifruit, a syndrome that appears after 4–5 months of cold storage. However, it is assumed that the infection takes place in the field during fruit development. The present work takes into consideration the production of volatile organic compounds (VOCs) of Actinidia deliciosa ‘Hayward’ at different phenological phases as potential C. luteo‐olivacea infection biomarkers. In vitro assays were conducted to gain knowledge on the effect of kiwifruit VOCs on pathogen conidial germination and mycelial growth. VOCs produced by kiwifruit either inoculated or not with C. luteo‐olivacea were analysed at different phenological phases by SPME/GC–MS analysis. In particular, ethanol, o‐xylene, d‐limonene and acetic acid showed a significant increase in the presence of fungal inoculation. Ethanol and d‐limonene were also detected as volatile metabolites of the pathogen. The effect of each compound (ethanol, o‐xylene, d‐limonene and acetic acid) was tested on the fungal conidial germination at different concentrations, showing a growth stimulation at lower amounts. These results show how the production of some VOCs can contribute to the knowledge of fruit–pathogen interaction in the field with the aim of developing future tools for early disease detection and consequent effective control.
Intelligent play: How improv can improve clinician's emotional intelligence
Authors: Mehta Ankit , Hendel‐Paterson Brett , Shah Nilesh , Hemphill Jesse , Adams Nell , Fredrickson Mary 
Published: January 2024

AbstractBackgroundEmotional intelligence (EI) of physicians significantly impacts their personal well‐being and professional success with broad implications in health care. A focused training on EI is often lacking in medical curricula. We sought to understand the impact of improvisation training on clinicians' EI.ApproachFour online medical improv workshops were offered to a diverse group of physicians with varied levels of practice experience including medicine‐paediatric residents, paediatric educators, practising paediatricians and internal/family medicine clinicians. The improv training was thoughtfully curated and remained consistent for all four cohorts, lasting 2 h. Self‐reported EI scales (pre and post) were captured using an online survey tool. The overall EI score and the scores of three EI components were compared before and after training.EvaluationOut of 64 participants, 41 participants (64%) completed both the pre‐ and post‐surveys and were included in the final analysis. Participant's pre‐training score (mean:123.9, range: 121.1–126.7) was compared to their post‐training score (mean:128.9, range: 126.3–131.3). The t tests comparing EI scores showed that compared to pre‐intervention, participants on average scored 4.9 points higher (95% CI: 3.1–6.7; p < 0.01) on the overall scale, 2.2 points higher (95% CI: 1.2–3.2; p < 0.01) on the appraisal score, 1.4 points higher (95% CI: 0.8–2.0; p < 0.01) on the regulation score and 1.2 points higher (95% CI: 0.4–2.1; p = 0.01) on the utilisation score.ImplicationsImprov training is an innovative method to fill the crucial gap in EI curricula. There was a statistically significant improvement in average score for clinicians' EI after a pilot improv training programme.
Reimagining rural clinical education from lessons learnt during COVID
Authors: Billett Stephen , Noble Christy , Sturman Nancy , O'Shannessy Megan , Brumpton Kay , Le Anh Hai 
Published: January 2024

AbstractBackgroundSecuring access to sufficient and focussed learning experiences is a perennial challenge for medical trainees. This challenge was accentuated during the COVID‐19 pandemic lockdowns and with physical isolation processes that decreased in‐person patient presentations and a shift to telehealth consultations. This situation has prompted the need to optimise the available experiences and educational responses to overcome the limitations in the number, quantum and range of available clinical learning experiences.MethodsSemi‐structured interviews were conducted with medical practice teams in four rural general practices to understand how medical trainees' education in rural general practices can be sustained in such circumstances.FindingsKey considerations included optimising the available experiences to assist medical trainees to generate the kinds of mental models needed by trainees to conduct medical work, and particularly, when it became even more restricted through remote or physically distanced consultations. It also identified lessons learnt during COVID‐19 pandemic lockdowns to inform and improve the provision of trainees' experiences in such practices.DiscussionProviding experiences for trainees to participate fully in clinical activities is imperative. A sequenced set of experiences was proposed to incrementally prepare trainees to engage in and conduct clinical consultations remotely using digital technologies.ConclusionSuch an approach may not always be easy or possible to enact but offers a pathway of experiences most likely to lead to positive outcomes for the trainees whilst maintaining patient care and safety considerations.
How medical students' trauma histories affect their clinical clerkship experiences
Authors: Neff Katherine , McKean Erin , Miller Madison , Fitzgerald James T. , Owens Lauren , Morgan Helen K. 
Published: January 2024

AbstractBackgroundAs the gender demographics of medical students have evolved over the past decades, it is important to understand potential stressors and challenges that may affect clinical learning experiences. This study investigated the prevalence of prior sexual assault (SA) and interpersonal violence (IPV) in medical students and how these affect their clinical clerkship experiences.MethodsA survey was distributed to third‐ and fourth‐year medical students at a single institution in August 2022 querying respondents on demographics and prior experiences with SA/IPV at any point in their lives. Respondents who indicated they had previously experienced SA/IPV were directed to questions about how these experiences affected clerkships.FindingsOf 419 students, 125 responded to the survey (30.8% response rate). Forty (31.1%) reported a history of SA/IPV—32 (80.0%) women, five (12.5%) men, and three (7.5%) who did not report gender or identified as non‐binary. Of the 40 respondents with a history of SA/IPV, 20 (50.0%) reported that their prior history affected their overall clinical experience, and nine (22.5%) felt that it affected their performance. Only seven (17.5%) reported using any resources, such as counselling, during their clerkships. Narrative responses discussed significant effects on performing physical exams, taking a history, interacting with team members, and engaging during clerkships.DiscussionThis work demonstrates the high number of students affected by SA/IPV and how these prior experiences affected core components of their clerkship experiences.ConclusionsInstitutions must be proactive to create better supports for learners with histories of trauma, including SA/IPV.