bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molluscum contagiosum presenting as periorbital abscess in immunocompetent children
Authors: Mor-Shaham Moran , Gutovitz Joel , Levinkron Oz , Krausz Judit , Briscoe Daniel 
Published: October 2023

AbstractMolluscum contagiosum presenting as a periorbital region abscess is unusual. The virus generally causes a self-limiting localized disease in children. Presentation as an abscess has been reported mainly in immunocompromised patients. We performed a retrospective study of ten children treated for Molluscum contagiosum infection presenting as periorbital abscess. Data investigated included age, immunocompetence, systemic antibiotic treatment, clinical findings, and histopathology. All children were immunocompetent. Bacterial cultures taken in six of the ten children were positive in two. Seven patients received oral antibiotics before presentation but required IV antibiotics on admission. One patient received IV antibiotics only. All antibiotic treatment had very limited effect. Two patients had no antibiotic treatment. CT imaging in one case where orbital cellulitis was suspected showed no significant intraorbital findings with anterior involvement only. Nine out of ten children had surgery and intra-operative cryotherapy at our center with immediate improvement and recovery. One child whose parents initially refused surgical excision had initial limited clinical improvement of periorbital swelling with antibiotics. However, the lesions were excised shortly following discharge from our hospital at another medical center with a complete cure. Molluscum is a cause of periorbital abscess in immunocompetent children which should be part of the differential diagnosis in periorbital/adnexal infection. Antibiotic treatment has a limited effect, and the abscess is most likely a virally triggered reaction. Surgical excision and intra-operative cryotherapy are curative of the disease in our experience.
Analysis of influencing factors on vibration characteristics of electro-hydraulic vibration cutting system
Authors: Xie Miao , Meng Qingshuang , Zhang Wenzhuo , Wang He , Guo Jianfeng , Liu Yuan , Yan Wenxing , Li Bo 
Published: October 2023

AbstractThe cutting process of the cantilever tunneling machine mainly generates excitation through the cutting motor or the hydraulic cylinder driven by the hydraulic system. Regardless of the driving method, the frequency width of the excitation system is limited, difficult to control, and the excitation effect is poor. Therefore, in order to improve excavation efficiency, the excitation system parallel to the original cutting and rotating system is designed. Based on the excitation characteristics caused by alternating fluid flow, the core component of the excitation system, hydraulic exciter, is designed, and the dynamics and dynamic characteristics of the excitation system are analyzed. Based on AMESim software, analyze the impact of factors such as pump displacement, excitation frequency, and pipeline parameters on the operational performance of the electro-hydraulic vibration cutting system, and conduct experimental verification by building a cutting test bench. The experimental results show that as the inner diameter of the pipeline increases, the fluctuation at the acceleration turning point decreases in each cycle and approaches the peak faster. As the excitation frequency increases, the cutting acceleration of the electro-hydraulic excitation cutting system decreases first and then increases, verifying the accuracy of the simulation results. In the experiment, it was found that the acceleration transformation range of the cutting head of the excitation system is the smallest and most stable when the excitation frequency is 30 Hz. In order to verify that the excitation frequency of 30 Hz is the optimal frequency, further contact force tests were conducted on the cutting teeth. It was found that when the hydraulic excitation system adds a 30 Hz excitation frequency, the contact force on the cutting teeth is the smallest. It is more conducive to reducing the damage and wear of the cutting head, and the cutting effect of the cutting head is more obvious. The research results are beneficial for improving the cutting performance of the electro-hydraulic excitation cutting system, providing theoretical support for the selection of cutting parameters for excavation machinery and hydraulic excitation, and improving the existing theoretical system for active excitation cutting vibration analysis of excavation machines.
Omega 3 fatty acid improves sexual and erectile function in BPF-treated rats by upregulating NO/cGMP signaling and steroidogenic enzymes activities
Authors: Odetayo Adeyemi Fatai , Olayaki Luqman Aribidesi 
Published: October 2023

AbstractBisphenol F (BPF) is an environmental pollutant that has been implicated in sexual dysfunction. Omega 3 fatty acid (O3FA), on the other hand, is an antioxidant with the ability to improve fertility indices. However, no study has explored the possible ameliorative effect of O3FA on BPF-induced sexual dysfunction. Thus, the effect of BPF and/or O3FA on male sexual performance was investigated. Male Wistar rats were randomized into 6 groups, corn oil-treated, O3FA low and high dose (100 and 300 mg/kg), BPF-treated, BPF + O3FA low and BPF + O3FA high dose. BPF significantly impaired male sexual competence, evidenced by a reduction in motivation to mate, prolonged mount, intromission and ejaculation latency, and post-ejaculatory index. Furthermore, a reduction in mount, intromission, and ejaculation frequency were observed. Also, BPF caused a decrease in gonadotropin releasing hormone, follicle stimulating hormone, luteinizing hormone, testosterone, nitric oxide (NO) cyclic guanosine monophosphate (cGMP), 3beta-hydroxysteroid dehydrogenase (3β-HSD), 17beta-hydroxysteroid dehydrogenase (17β-HSD), dopamine, and acetylcholine esterase. Furthermore, it was accompanied by a significant increase in prolactin and estrogen and poor pregnancy outcomes. These observed BPF-led alterations were abolished by O3FA administration. This study showed that O3FA ameliorates BPF-induced sexual dysfunction by upregulating NO/cGMP signaling and steroidogenic enzymes activities.
Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep
Authors: Cao Yutao , Ai Yue , Zhang Xiaosheng , Zhang Jinlong , Long Xianlei , Zhu Yaning , Wang Linli , Gu Qingyi , Han Hongbing 
Published: October 2023

AbstractHypertrophy and fiber transformation are two prominent features of postnatal skeletal muscle development. However, the role of epigenetic modifications is less understood. ATAC-seq, whole genome bisulfite sequencing, and RNA-seq were applied to investigate the epigenetic dynamics of muscle in Hu sheep at 3 days, 3 months, 6 months, and 12 months after birth. All 6865 differentially expressed genes were assigned into three distinct tendencies, highlighting the balanced protein synthesis, accumulated immune activities, and restrained cell division in postnatal development. We identified 3742 differentially accessible regions and 11799 differentially methylated regions that were associated with muscle-development-related pathways in certain stages, like D3-M6. Transcription factor network analysis, based on genomic loci with high chromatin accessibility and low methylation, showed that ARID5B, MYOG, and ENO1 were associated with muscle hypertrophy, while NR1D1, FADS1, ZFP36L2, and SLC25A1 were associated with muscle fiber transformation. Taken together, these results suggest that DNA methylation and chromatin accessibility contributed toward regulating the growth and fiber transformation of postnatal skeletal muscle in Hu sheep.
Lunar ejecta origin of near-Earth asteroid Kamo’oalewa is compatible with rare orbital pathways
Authors: Castro-Cisneros Jose Daniel , Malhotra Renu , Rosengren Aaron J. 
Published: October 2023

AbstractNear-Earth asteroid, Kamo’oalewa (469219), is one of a small number of known quasi-satellites of Earth; it transitions between quasi-satellite and horseshoe orbital states on centennial timescales, maintaining this dynamics over megayears. The similarity of its reflectance spectrum to lunar silicates and its Earth-like orbit both suggest that it originated from the lunar surface. Here we carry out numerical simulations of the dynamical evolution of particles launched from different locations on the lunar surface with a range of ejection velocities in order to assess the hypothesis that Kamo‘oalewa originated as a debris-fragment from a meteoroidal impact with the lunar surface. As these ejecta escape the Earth-Moon environment, they face a dynamical barrier for entry into Earth’s co-orbital space. However, a small fraction of launch conditions yields outcomes that are compatible with Kamo‘oalewa’s orbit. The most favored conditions are launch velocities slightly above the escape velocity from the trailing lunar hemisphere.
A Comparison of Listening Skills of Autistic and Non-Autistic Youth While Using and Not Using Remote Microphone Systems
Authors: Thompson Emily , Feldman Jacob I. , Valle Annalise , Davis Hilary , Keceli-Kaysili Bahar , Dunham Kacie , Woynaroski Tiffany , Tharpe Anne Marie , Picou Erin M. 
Published: October 2023

Objectives:
The purposes of this study were to compare (a) listening-in-noise (accuracy and effort) and (b) remote microphone (RM) system benefits between autistic and non-autistic youth.

Design:
Groups of autistic and non-autistic youth that were matched on chronological age and biological sex completed listening-in-noise testing when wearing and not wearing an RM system. Listening-in-noise accuracy and listening effort were evaluated simultaneously using a dual-task paradigm for stimuli varying in type (syllables, words, sentences, and passages). Several putative moderators of RM system effects on outcomes of interest were also evaluated.

Results:
Autistic youth outperformed non-autistic youth in some conditions on listening-in-noise accuracy; listening effort between the two groups was not significantly different. RM system use resulted in listening-in-noise accuracy improvements that were nonsignificantly different across groups. Benefits of listening-in-noise accuracy were all large in magnitude. RM system use did not have an effect on listening effort for either group. None of the putative moderators yielded effects of the RM system on listening-in-noise accuracy or effort for non-autistic youth that were significant and interpretable, indicating that RM system benefits did not vary according to any of the participant characteristics assessed.

Conclusions:
Contrary to expectations, autistic youth did not demonstrate listening-in-noise deficits compared to non-autistic youth. Both autistic and non-autistic youth appear to experience RM system benefits marked by large gains in listening-in-noise performance. Thus, the use of this technology in educational and other noisy settings where speech perception needs enhancement might be beneficial for both groups of children.
Water ice: Temperature-dependent refractive indexes and their astrophysical implications
Authors: Rocha W. R. M. , Rachid M. G. , McClure M. K. , He J. , Linnartz H. 
Published: October 2023

Context. Interstellar and circumstellar ices are largely composed of frozen water. Therefore, it is important to derive fundamental parameters for H2O ice such as absorption and scattering opacities, for which accurate complex refractive indexes are needed.
Aims. The primary goal of the work presented here is to derive ice-grain opacities based on accurate H2O ice complex refractive indexes at low temperatures and to assess the impact this has on the derivation of water ice column densities and porosity in space.
Methods. We used the optool code to derive ice-grain scattering and absorption opacity values based on new and previously reported mid-infrared (mid-IR) complex refractive index measurements of H2O ice, primarily in its amorphous form, but not exclusively. Next, we used those opacities in the RADMC-3D code to run a radiative transfer simulation of a protostellar envelope containing H2O ice, which was then used to calculate water ice column densities.
Results. We found that the real refractive index in the mid-IR of H2O ice at 30 K is ~14% lower than previously reported in the literature. This has a direct impact on the ice column densities derived from the simulations of embedded protostars. Additionally, we found that ice porosity plays a significant role in the opacity of icy grains and that the H2O libration mode can be used as a diagnostic tool to constrain the porosity level. Finally, the refractive indexes presented here allowed us to estimate a grain size detection limit of 18 μm based on the 3 μm band, whereas the 6 μm band allowed us to trace grain sizes larger than 20 μm.
Conclusions. Based on radiative transfer simulations using new mid-IR refractive indexes, we conclude that H2O ice leads to more absorption of infrared light than previously estimated. This implies that the 3 and 6 μm bands remain detectable in icy grains with sizes larger than 10 μm. Finally, we also propose that the H2O ice libration band can be used as a diagnostic tool to constrain the porosity level of the interstellar ice, in addition to the OH dangling bond, which is now routinely used for this purpose.
Liver Injury after Selective Androgen Receptor Modulator Intake: A Case Report and Review of the Literature
Authors: Mertens Jonas E. , Bömmer M. Till C. , Regier Manuel B. , Gabriëls Gert , Pavenstädt Hermann , Grünewald Inga , Horvath Judit , Trebicka Jonel , Schmidt Hartmut , Schlevogt Bernhard 
Published: October 2023

AbstractLiver injury associated with selective androgen receptor modulators (SARMs) is an issue that has not been reported often. We report a case of a previously healthy 24-year-old male, who was referred to our hospital for severe jaundice with intense pruritus. He had previously taken the SARM Enobosarm (also known as Ostarine) for muscle-building purposes. Blood serum levels of total bilirubin exceeded 30 mg/dL with only a slight elevation of liver enzymes. Liver biopsy revealed isolated hepatocellular cholestasis (bland cholestasis) with limited inflammation or necrosis. Supportive treatment was begun in our hospital with molecular adsorbent recirculation system (MARS) albumin dialysis, as well as cholestyramine for pruritus relief. During therapy, bilirubin levels and symptoms regressed, and after five sessions of dialysis, the patient could be released from our clinic in a markedly improved clinical and laboratory condition. However, bilirubin parameters regressed slowly after this, reaching normal levels as late as six months after first intake of the compound. Exome-based genetic testing brought about no pathogenic variants for cholestatic liver disease in our patient. Nevertheless, three common heterozygous polymorphisms associated with an increased risk for intrahepatic cholestasis could be identified. Our case demonstrates that SARMs can cause severe liver injuries not prominently mentioned in safety data sheets. Therefore, these compounds constitute a potential danger to the user’s health. This holds especially true when taking SARMs without supervision by a medical professional, which should consist of a thorough monitoring of liver enzyme and bilirubin levels.
Augenbeteiligung bei kongenitalen Infektionen – TORCH
Authors: Thurau Stephan 
Published: October 2023

ZusammenfassungIn dieser Übersichtsarbeit werden die opththalmologischen Befunde bei kongenitalen Infektionen zusammengefasst. Intrauterine Infektionen sind eine wichtige Ursache für Erblindungen im
Kindesalter. Die häufigsten Infektionen werden unter dem Akronym TORCH zusammengefasst, das für Toxoplasma gondii, andere (others), Rubella, CMV und Herpes simplex steht. Insgesamt sind
diese Infektionen in den Ländern der Ersten Welt in der Schwangerschaft nicht sehr häufig, aber wegen der Bedrohung des Sehvermögens von besonderer Bedeutung. Die Diagnostik von Infektionen
oder Reaktivierungen ist eine gynäkologische Herausforderung. Die augenärztliche Untersuchung der Neugeborenen kann aber entsprechend gezielt erfolgen, wenn der Erreger bekannt ist. Die
wichtigsten Therapeutika, die beim Neugeborenen Anwendung finden, sind dargestellt.
β-Thalassemia and Diabetes Mellitus: Current State and Future
Directions
Authors: Taneera Jalal , Mahgoub Eglal , Qannita Reem , Alalami Ayah , Shehadat Ola Al , Youssef Mona , Dib Ayah , Hajji Alaa Al , Hajji Amani Al , Al-Khaja Fatheya , Dewedar Hany , Hamad Mawieh 
Published: October 2023

Abstractβ-Thalassemia major is a congenital hemoglobin disorder that requires
regular blood transfusion. The disease is often associated with iron overload
and diabetes mellitus, among other complications. Pancreatic iron overload in
β-thalassemia patients disrupts β-cell function and insulin
secretion and induces insulin resistance. Several risk factors, including family
history of diabetes, sedentary lifestyle, obesity, gender, and advanced age
increase the risk of diabetes in β-thalassemia patients. Precautionary
measures such as blood glucose monitoring, anti-diabetic medications, and
healthy living in β-thalassemia patients notwithstanding, the prevalence
of diabetes in β-thalassemia patients continues to rise. This review
aims to address the relationship between β-thalassemia and diabetes in
an attempt to understand how the pathology and management of
β-thalassemia precipitate diabetes mellitus. The possible employment of
surrogate biomarkers for early prediction and intervention is discussed. More
work is still needed to better understand the molecular mechanism(s) underlying
the link between β-thalassemia and diabetes and to identify novel
prognostic and therapeutic targets.
Medical Treatment for Androgenetic Alopecia
Authors: Panchaprateep Ratchathorn 
Published: October 2023

AbstractAndrogenetic alopecia is a common type of hair loss, which is generally influenced by genetic factors and systemic androgens resulting in follicular miniaturization.1 It can cause cosmetic problems leading to psychological distress among affected men and women. Effective standard medical treatments available are topical minoxidil 2 to 5%, oral finasteride, oral dutasteride, and hair transplantation.1 However, some patients do not achieve favorable results with standard treatments. For these reasons, other novel treatments have been developed, including new medications, regenerative medicines (autologous platelet-rich plasma, adipose-derived stem cells, micrograft generation, and exosome), and low-level laser therapy
Maternal Group B Streptococcus Prophylaxis Improvement using an Electronic Medical Record Dynamic Order Set
Authors: Tomlinson Mark W. , Baker Rachael , Ulrich Jennifer , Shah Maulin , Marginean Horia , Girolami Stephen 
Published: October 2023

Objective To develop and implement a Group B Streptococcal (GBS) dynamic order set to improve adherence to the American College of Obstetricians and Gynecologists/Centers for Disease Control and Prevention (ACOG/CDC) guidelines.
Study Design A team of information technology and clinical experts developed a dynamic order block. The content was patterned after the CDC “Prevent GBS” mobile app. It was then embedded in the labor and delivery/induction order set and piloted at a single high-volume obstetric unit. Following the pilot and incorporation of the 2019 ACOG update of the CDC guidelines, the order set was rolled out in five additional hospitals within a region of a large health system. Information on GBS prophylaxis performance before and after implementation was available for the pilot site and four of the additional hospitals. Information before implementation was obtained electronically from electronic medical record (EMR) laboratory and pharmacy data and supplemented by manual chart review. Postimplementation data were obtained from discrete order set EMR data elements. Adherence to the guidelines before and after were compared using chi-squared test.
Results There were 7,114 deliveries before implementation and 4,502 after implementation. Preterm delivery occurred in 6.8 and 6.9%, respectively. There was an increase in appropriate treatment of preterm patients (positive and unknown GBS) delivering after implementation (88.7–99.1%, p < 0.001). More patients were reported to have a penicillin allergy before implementation than after implementation (14.7 vs. 11.1%, respectively, p = 0.01). Associated changes in therapy noted after implementation included a nonsignificant decrease in the proportion reporting a high-risk allergy (50.3 vs. 41.9%, p = 0.18), an increase in the appropriate use of clindamycin and vancomycin (64.4 vs. 92.3%, p < 0.001) and a decrease in clindamycin use in those without sensitivity testing.
Conclusion Routine universal use of a dynamic admission labor/induction order set was associated with high and improved adherence to GBS prophylaxis guidelines.
Key Points
Impact of Strength Training Intensity on Brain-derived Neurotrophic
Factor
Authors: Borges Junior Marcos , Tavares Larissa Ferreira Jacomini , Nagata Gabriela Yumi , Barroso Lucélia Scarabeli Silva , Fernandes Heliana Barros , Souza-Gomes Antonio Felipe , Miranda Aline Silva , Nunes-Silva Albená 
Published: October 2023

AbstractThe present study employed a randomized crossover design to investigate the
effect of strength-training exercise at varying intensities on acute changes in
plasma brain-derived neurotrophic factor (BDNF) levels. Fourteen trained male
subjects (41.0±5.8 years old) were enrolled in the current study. The
strength-training protocol included bench press, leg press, and lat pull-down
exercises. Participants performed four sets with repetition failure at
60% or 80% of their one-repetition maximum (1RM), with a
two-minute rest period. The order of intensity was randomized among volunteers.
Blood samples were collected before, immediately after, and one hour after each
exercise protocol. A time-point comparison revealed that a single session of
strength training at 60% of 1RM increased lactate plasma concentrations
from 1.2 to 16 mmol/L (p<0.0001). However, no
significant changes were observed in the plasma BDNF concentration. Conversely,
the training session at 80% of 1RM increased lactate concentrations from
1.3 to 14 mmol/L (p<0.0001) and BDNF concentrations from
461 to 1730 pg/ml (p=0.035) one hour after the session’s
conclusion. These findings support the hypothesis that a single
strength-training session at 80% 1RM can significantly enhance
circulating levels of BDNF.
Electromyographic Activity of Lower Limb Muscles during Ankle
Destabilizing Tests
Authors: Dury Jeanne , Michel Fabrice , Ravier Gilles 
Published: October 2023

AbstractAnkle destabilizing devices were developed to improve the recruitment of the
evertor muscles. Nevertheless, the activity of lower-leg muscles has never been
compared to each other during functional tests performed with destabilization.
The objectives were i) to compare the electromyographic activity between the
lower-leg muscles during four functional tests performed with ankle
destabilization, and ii) to determine sex-related differences in neuromuscular
activation. Twenty-six healthy volunteers (13 males, 13 females) performed the
modified Star Excursion Balance Test (mSEBT), unipedal balance and
weight-bearing inversion and eversion tests with a destabilizing device, while
recording electromyographic activity of the peroneus longus and brevis, tibialis
anterior, gastrocnemius lateralis and gluteus medius. The activity of peroneal
muscles was significantly greater than other muscles during all functional
tests. Furthermore, the anterior direction of the mSEBT was the one implying the
greatest activity of the peroneus longus muscle compared to the posteromedial
(p=0.003) or posterolateral (p<0.001) directions. Finally, no
significant sex-related differences in neuromuscular activity were reported.
This study highlights the effectiveness of the destabilizing device to involve
specifically the peroneal muscles when performing various functional tests. This
device should be used by clinicians to be more specific to the stabilizers of
the ankle joint during functional exercises.