bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemokines, their receptors and features of development of the immune answer
Authors: Moskalev A. V. , Rudoy A. S. , Apchel V. Ya. 
Published: November 2023

The general characteristic chemokines as is given the fibers participating in various immunophysiological and immunopathological processes. Features of their secretion, interaction with profile receptors, expression immunologic competence cages are reflected. The priority principle of interaction chemokines with corresponding receptors, and also prevalence concrete cytokines for development of the immune answer either on Thl, or on a Th2-way is shown. Chemokines besides maintenance of migration of leukocytes regulate angiogenesis, stimulate an exit of haemopoetic predecessors in ischemia sites, and also regulate development and prolipheration B-lymphocytes. The metabolism of chemokines is closely connected with matrix metalloproteinase which carry out proteolysis chemokines, change transit of leukocytes. They are capable as to inactivate chemokines, and to split them, promoting occurrence of the antagonists connecting a receptor without carrying out of a signal.
Along with general characteristics of chemokines, features of participation chemokines in development antibacterial and antiviral immune answers are described. It is established that a number chemokines, operating through concrete receptors, provide angiogenesis tumours, promote progressing of tumoral process both direct, and the mediated mechanisms. Some chemokines, are necessary for metastasizing for a tumour, providing distribution of tumoral cages to bodies, where expression for them corresponding receptors. And others chemokines, produced, in particular fibroblastes, stimulate a survival and growth of neoplastic cages paracrine with a way. The special role lipoprotein is shown low density in an induction lisso and endotheliocyte by cages macrophage chemotaksis a protein, interleukin-8, fractalkine in processes aterogenesis.
Comparison of Ground-Shaking Hazard for Segmented versus Multifault Earthquake-Rupture Models in Aotearoa New Zealand
Authors: Howell Andy , Nicol Andrew , Bora Sanjay , Gerstenberger Matt , Van Dissen Russ , Chamberlain Chris , DiCaprio Christopher J. , Rollins Chris , Stirling Mark , Jurgens Oakley , Shaw Bruce E. 
Published: November 2023

Abstract
Multifault ruptures are common for historical earthquakes, and here we consider their impact on seismic hazard. We compare ground-shaking hazard forecasts from the 2022 Aotearoa New Zealand National Seismic Hazard Model (NZ NSHM 2022), which incorporates many multifault ruptures (referred to as the multifault model) with modeled hazard from a simpler model of characteristic earthquakes on individual faults or fault segments (referred to as the segmented model). The multifault model includes very-low-probability rupture lengths of up to ∼1100 km and a mean of 221–234 km, whereas the segmented model primarily comprises rupture lengths of &lt;200 km (mean, 43–51 km) and the maximum of 414 km. The annual rates of Mw 6.9–7.5 earthquakes are more than an order of magnitude higher for the segmented model (0.132–0.24/yr; recurrence times ∼4–7 yr) than the multifault model (0.027/yr; recurrence times 37 yr). Conversely, the rates of earthquakes are similar for segmented and multifault models at Mw&gt;7.5 (0.018–0.031/yr; recurrence times 32–56 yr). Despite differences in rupture lengths and annual rates of earthquakes, the calculated ground-shaking hazard at 10% probability of exceedance (PoE) in 50 yr for the segmented model differs by &lt;55% compared with the multifault model for 95% of sites across Aotearoa New Zealand. For 50% of sites, the modeled hazard differs by &lt;20% between the two models. If a distributed seismicity model (DSM) is included in the hazard calculations, 95% of sites differ in modeled hazard by &lt;18%, and 50% of sites differ by &lt;2.2%. In most areas, seismic hazard at 10% PoE in 50 yr is greater for the segmented model than the multifault model, with notable exceptions along the central Alpine fault in the western South Island and the Taupō volcanic zone in the central North Island.
Case report of palmoplantar psoriasis: Specific remedies to constitutional remedies for condition
Authors: Chothani Pulkesh , Rangani Pratiksha 
Published: November 2023

Psoriasis, an autoimmune and chronic inflammatory disease of the skin, can leave the patient in agony with its distressing infection episodes. Palmoplantar psoriasis is a chronic variant of psoriasis that characteristically affects the skin of the palms and soles and produces significant functional disability. It features hyperkeratotic, pustular, or mixed morphologies. Palmoplantar psoriasis is a variant of psoriasis and accounts for 3–4% of total cases of psoriasis. Though historically difficult to treat, recent studies on biologic therapies have shown promising results for the treatment of palmoplantar psoriasis. This activity describes the pathophysiology, evaluation, and management of palmoplantar psoriasis and highlights the role of the interprofessional team in the care of affected patients. The homoeopathic system of medicine offers a wide range of medicines that can have a beneficial role in managing cases of psoriasis as depicted in the previous studies. 1. Identify the trigger factors and aetiology for palmoplantar psoriasis. 2. Describe the mental and physical presentation of a patient with palmoplantar psoriasis. 3. Summarize the out of treatment and management options available fin homeopathy for palmoplantar psoriasis. 3. Review interprofessional team strategies for improving care coordination and communication to enhance outcomes for patients affected by palmoplantar psoriasis. 4. Review of recurrence of palmoplantar psoriasis.A distinct case of Palmoplantar psoriasis treated with homoeopathic remedies of ultrahigh potentised dilution has been presented here. The evidence-based illustrations were done before and after the treatment and the periodical objective assessment of the lesions with psoriasis area and severity index (PASI) calculation to ascertain the prognosis. The causal attribution of outcome to the treatment was evaluated using Modified Naranjo Criteria for Homoeopathy (MONARCH) tool. Marked improvement was found in the psoriatic lesions evidenced photographically and the PASI scores showed significant reduction affirming the same. The MONARCH score (+10) suggested that the clinical improvement was likely attributable to the homoeopathic treatment. This evidence-based case report suggests a beneficial role of homoeopathy in the treatment of palmoplantar psoriasis.
Application of Several Special Staining Methods for Paraffin Sections on Epon-Embedded Semithin Sections
Authors: AKBAŞ Ayşe , YAVAŞ Senem Esin , ERSOY Semiha , BAŞAR Doruk 
Published: November 2023

Aim: This study aimed to compare several specific staining protocols recommended for paraffin sections and toluidine blue and light green double staining combination to be tried for the first time with routine toluidine blue staining on semithin epon sections.
Material and Methods: Samples of 1x1x1 mm were taken from the liver, skin, and aorta tissues of Wistar albino adult rats. Tissue samples were fixed with 5% glutaraldehyde at +4º C overnight, postfixed with 1% osmium tetroxide for one hour, and then, blocked with Epon 812 after processing. Semithin sections of 1 μm thickness were obtained from the epon blocks. Sections were stained with Altmann’s method (for mitochondria), Verhoeff’s method (for elastic fibers), Gordon&Sweets’ silver impregnation method (for type III collagen), toluidine blue and light green double staining combination (for type I collagen) and routine toluidine blue method.
Results: In liver sections, mitochondria in hepatocytes were differentiated by the Altmann method, and stromal type III collagen fibers were distinguished with Gordon&Sweets’ method. Elastic lamellar structures were easily observed in black in the aortic sections stained with the Verhoeff method. Successful results were obtained in the staining of dermal type I collagen with toluidine blue and light green double staining in skin sections.
Conclusion: Since the specific staining tried for the first time gave positive results in epon sections, it was concluded that these methods can be used to determine the localization of cellular and intercellular components that are aimed to be examined at the ultrastructural level.
Filosofía y educación:
Authors: Soledad Martha , Ricardo Esaú 
Published: November 2023

En este libro, producto del trabajo realizado en el V Seminario de Investigación Permanente, nos enfrentamos en su edición con tres cuestiones que nos obligan a atravesar con muchas dificultades la formalidad académica y la lógica sistemática institucional, que se exige cuando se construyen problemas de investigación, y cuando se trata de poner en cuestión en un mismo espacio: por un lado los distintos puntos de vista, los diferentes problemas, estilos, preocupaciones y los objetos de estudio; por otro lado, estos elementos varían por su naturaleza, al igual que varían los tonos, acentos y marcas, y por último, los usos y las aplicaciones que se hace del saber filosófico, histórico, político y cultural para explicar y dar cuenta de estos en el campo de la educación.
El amanecer de una naranja roja
Authors: Neil Álvaro 
Published: November 2023

Álvaro Neil nos recuerda que somos hombres de aldea y que la poesía es una conversación, un diálogo infinito con el silencio en que los rituales de dioses milenarios nos llegan a través de la mansedumbre de la palabra. El poeta nos reta para regresar a lo esencial; el poeta es quien contempla, quien establece un diálogo interior con los elementos que componen el universo.
Simulación basada en dinámica de sistemas y agentes inteligentes, aplicada a un sistema complejo
Authors: Callejas Cuervo Mauro , Valero Bustos Helver Augusto , Alarcón Aldana Andrea Catherine 
Published: November 2023

Esta investigación propone una forma de integrar dos técnicas de simulación, una basada en agentes inteligentes y la segunda en dinámica de sistemas, aplicado a un caso de estudio real, en el cual se busca evaluar la calidad del servicio prestado en la operación de un sistema de transporte público colectivo urbano en ciudades intermedias, teniendo en cuenta el comportamiento de las variables complejas: comodidad y rapidez. Con dinámica de sistemas se hace un análisis macroscópico de la información y con agentes inteligentes se realiza un análisis microscópico; es así que en la integración propuesta, los resultados obtenidos con la simulación del modelo basado en agentes son parámetros de entrada para ejecutar la simulación con dinámica de sistemas.
Metamodelo de medición de esfuerzo en proyectos de desarrollo de software
Authors: Otalora Luna Jorge Enrique , Alarcón Aldana Andrea Catherine , Callejas Cuervo Mauro 
Published: November 2023

En este libro se propone un metamodelo basado en las características generales de los procesos de estimación de esfuerzo y los modelos de calidad y mejora de procesos, de esta forma pretende contribuir en la predicción del esfuerzo al interior de las organizaciones y ayudar a mejorar la planificación de los proyectos software. Se propone una herramienta para fomentar que la organización cuente con procesos definidos para la realización de las actividades orientadas al desarrollo de sus productos de software, para lo cual, es fundamental que éstas cuenten con una política de calidad de mejora de sus procesos.
Síntesis de productos químicos derivados de la biomasa empleando catálisis heterogénea heterociclos de la biomasa
Authors: Martínez José J. , Rojas Hugo Alfonso , Cubillos Jairo , Silva David , Aguilera Ximena , H. Oscar , Páez Luis , Becerra Mónica , Chaparro Sandra , P. Gustavo , Ruíz Diego 
Published: November 2023

En este libro se presentan los aspecto más relevantes relacionados con la producción de 5-HMF ésteres de ácido levulímico y FDCA principalmente, desde el punto de vista de los sustratos utilizados, los sistemas catalíticos y las condiciones de reacción. El último capítulo se dedica a la síntesis de heterocíclicos nitrogenados representativos que pueden prontamente llegar a se considerados también moléculas plataforma. El texto es el resultado de los proyectos de investigación desarrollados desde el 2015, y es presentado en conmemoración de los 20 años del grupo de catálisis de la UPTC con la finalidad de proveer un material de consulta para estudiantes y profesionales del área de la química interesados en conocer el estado actual de moléculas derivadas de la biomasa.
Implementasi Sistem Penyiraman Otomatis Pada Kumbung sebagai Upaya Peningkatan Hasil Budi Daya Jamur Tiram Desa Menawan
Authors: Wibowo Budi Cahyo , Rozaq Imam Abdul 
Published: November 2023

<p>Jamur tiram atau dalam bahasa latin disebut Pleurotus ostreatus adalah jamur dengan ciri fisik berbentuk cekung seperti cangkang tiram. Konsumsi jamur tiram yang semakin meningkat tiap tahunnya dan potensi pasar luar negeri yang tinggi untuk konsumsi jamurnya menjadikan produksi jamur tiram perlu ditingkatkan. Petani jamur tiram di desa menawan mengalami permasalahan dalam peningkatan produksi jamur diantaranya adalah proses perawatan budidaya jamur yang memerlukan perhatian khusus, diantaranya adalah proses penyiraman yang rutin dan terjadwal sehingga petani harus secara rutin melakukan penyiraman untuk menjaga kelembaban kumbung jamur tiram sehingga tidak efisien dari segi waktu dan tenaga. Berdasarkan permasalahan tersebut maka diperlukan teknologi tepat guna untuk melakukan penyiraman secara otomatis berbasis IoT melalui <em>smartphone</em> yang telah diimplementasikan pada kumbung jamur tiram di desa menawan kabupaten kudus. Dengan implementasi teknologi ini maka penyiraman jamur tiram dapat dilakukan melalui jarak jauh sehingga petani jamur tiram tidak harus datang ke kumbung untuk melakukan penyiraman. Sistem penyiraman otomatis ini bekerja berdasarkan kondisi kelembaban udara pada kumbung yang terbaca oleh sensor pH. Hasil panen jamur dengan menerapkan sistem penyiraman otomatis berhasil meningkatkan hasil panen dalam waktu 14 hari dengan kenaikan 83% atau naik 1.209 gram dari hasil panen dengan penyiraman konvensional pada media uji 15 baglog jamur tiram.</p>
Geological Aspects of the Formation and Distribution of Gas Anomalies in Bottom Sediments of the New Siberian Sedimentary Basin and Adjacent Geostructures of the East Siberian Sea
Authors: Gresov A.I. , Yatsuk A.V. 
Published: November 2023

Abstract
—In bottom sediments of the New Siberian sedimentary basin and adjacent geostructures of the East Siberian Sea, we identified СН4, as well as its limit and unsaturated homologues (up to and including C5H12), CO2, CO, H2, He, H2S, O2, N2, and Ar. Isotope-gas-geochemical parameters δ13С СО2, СН4 and С2Н6, of the molecular mass of hydrocarbon fraction and genetic coefficients indicate the presence of both syngenetic and epigenetic gases of various gas sources in sediments, including recent sediments, peatlands, coal-bearing and gas-bearing formations, solid bitumen, igneous formations, accumulations of gas hydrates and prognostic condensate-gas, condensate, oil-and-gas and gas-and-oil reservoirs. Concentrations of CO2 and CO reach 29.25 and 0.06 cm3/kg, CH4 and the sum of its homologues – 5.93 and 0.031, Н2 and He – 0.78 and 0.318, H2S – 0.092 cm3/kg; this indicates that gas-geochemical anomalies, exceeding the anomaly criteria by 6–124 times, form in bottom sediments. The formation and distribution of abnormal concentrations of natural gases depend on the complex influence of gas-controlling factors – geological structure, fold and fault tectonics, magmatism, coal-oil-gas content, bituminous content, organic saturation, lithological composition, water-physical and reservoir properties of sediments, hydrogeological, geocryological and other conditions for accumulation of natural gases or their degassing.
Geographic Object-Based Image Analysis (GEOBIA) for Landslide Identification using Machine Learning on Google Earth Engine (GEE)
Authors: Khadka Diwakar , Zhang Jie 
Published: November 2023

Abstract
Landslides significantly threaten human life and infrastructure, requiring accurate and timely identification for effective hazard assessment and management. In this study, we propose a novel approach for landslide identification by integrating Geographic Object-Based Image Analysis (GEOBIA) with advanced techniques and machine learning algorithms. Our methodology includes Simple Non-iterative Clustering (SNIC) segmentation, which divides the image into super-pixels, enabling a detailed analysis at the object level, Gray Level Co-occurrence Matrix (GLCM) feature extraction, which is employed to capture important textural information, Principal Component Analysis (PCA) for dimensionality reduction which helps to reduce the dataset's complexity by transforming the original set of variables into smaller sets of uncorrelated variables recognized as principal components, and the utilization of various machine learning algorithms such as (i) Support vector machine (SVM), (ii) Random Forest (RF), and (iii) Classification and Regression Trees (CART). We utilize the Google Earth Engine (GEE) platform to leverage extensive geospatial data and computational power. The performance of SVM, RF, and CART algorithms is evaluated for landslide detection. SVM demonstrates superior accuracy in detecting landslides, achieving an overall accuracy of 89.01%, surpassing RF (87.82%) and CART (73.31%). The effectiveness of our proposed approach, which involves integrating SNIC segmentation, GLCM feature extraction, PCA analysis, and SVM classification, has been underscored in accurately and efficiently identifying landslides. Combining advanced techniques and machine learning algorithms within the GEOBIA framework with the GEE platform offers promising results for improving landslide identification, monitoring, risk assessment, supporting proactive measures, and mitigating landslide risks.
AdductHunter: Identifying Protein-Metal Complex Adducts in Mass Spectra
Authors: Long Derek , Eade Liam , Sullivan Matthew P , Dost Katharina , Meier-Menches Samuel M , Goldstone David C , Hartinger Christian G , Wicker Jörg S , Taskova Katerina 
Published: November 2023

Abstract
Mass spectrometry (MS) is an analytical technique for molecule identification that can be used for investigating protein-metal complex interactions. Once the MS data is collected, the mass spectra are usually interpreted manually to identify the adducts formed which arise from the interactions between proteins and metal-based species. However, with increasing resolution, dataset size, and species complexity, the time required to identify adducts and the error-prone nature of manual assignment have become limiting factors in MS analysis. AdductHunter is an analysis tool to automate the peak identification process using constraint integer optimization to find feasible combinations of protein and fragments, and dynamic time warping to calculate the dissimilarity between the theoretical isotope pattern of a species and its experimental isotope peak distribution. Our results show fast and accurate identification of protein adducts to aid mass spectrometry analysis.
Genetic and comparative genome analysis of the dibenzothiophene-desulfurizing Gordonia SWX-4
Authors: Xu Yuanyuan , Cheng Tao , Ma Zhiwei , Zhang Shuqi , Rao Qingyan , ma yanling 
Published: November 2023

Abstract

Biodesulfurization of crude oil is a highly promising technology for achieving thorough desulfurization. In this study, a bacterial strain, designated as SWX-4, was isolated from sandstone oil in the Ordos Basin that had the ability to utilize dibenzothiophene (DBT) as a carbon source. Through physiological and biochemical characterization as well as 16S rRNA sequencing, the isolate was identified as Gordonia sp. The genome of strain SWX-4 was found to be 5,303,410 bp in size, with a GC content of 67.44%. It comprised 12 rRNA genes, 51 tRNA genes, and two plasmids. Genome analysis revealed the presence of 4,683 functional genes potentially involved in DBT desulfurization, as well as the oxidation of alkanes and aromatic compounds. Notably, the genome of strain SWX-4 also contained genes encoding sfnG, sfnB, and terD, which are known to be responsible for the desulfurization activity of DBT. These genes exhibited functional similarity to the well-conserved dszABC operons. Furthermore, a comparative genomic analysis of 43 Gordonia strains isolated from various habitats was conducted to explore their genetic diversity. The results revealed that Gordonia sp. possesses an open pan-genome with a total of 774 core genes present across all strains. On average, these core genes accounted for 18% of each individual genome. Additionally, phylogenetic tree analysis and the distribution of accessory genes showed that each strain harbored a distinct set of unique genes. Interestingly, genes associated with biodesulfurization were found to be distributed among different branches of the phylogenetic tree. This suggests that these strains have the capacity to acquire new genes through horizontal gene transfer from their environments, thereby increasing the diversity of their bacterial genomes. However, we did not observe a direct evolutionary correlation between the bacterial genome and desulfurization metabolism. Overall, our findings provide valuable insights into the biodegradation of DBT by the SWX-4 strain and offer an efficient bacterial resource for biodesulfurization.
Immune-Oncology Targets and Therapeutic Response of Cell Pyroptosis-Related Genes with Prognostic Implications in Neuroblastoma
Authors: Liu Xingyu , Xu Zhongya , Yin Hanjun , Zhao Xu , Duan Jinjiang , Zhou Kai , Shen Qiyang 
Published: November 2023

Abstract
Objective Construction of a NB prognostic model based on pyroptosis-related genes (PRGs) to improve individualized management of NB patients.
Methods The GEO-NB cohort from the Gene Expression Omnibus (GEO) database was obtained and randomized into training and test groups, and finally 498 cases were included for analysis. The model was constructed using the training set, and the test set data were used as the validation set to screen for prognostically significant variables using the Log-rank test, and then the optimal multigene prognostic model was built using LASSO-Cox regression analysis. The accuracy of the prognostic model was assessed using ROC curves, column plots, and calibration curves.
Results A prognostic model was first developed with the training set: the risk score formula was (-0.30 × GSDMB) + (-0.46 × IL18) + (-0.21 × NLRP3) - (0.56 × AIM2). Patients were categorized into high- and low-risk groups based on the median risk score value. Survival analysis showed that NB patients in the high-risk group had a significantly lower survival rate than those in the low-risk group (P < 0.001). The area under curve (AUC) of the time-dependent ROC curve predicting 5-, 7.5-, and 10-year survival was 0.843, 0.802, and 0.797, respectively. In the GEO test cohort, patients in the high-risk group had worse prognostic patients compared with those in the low-risk group (P=0.035). The calibration curve of the alignment diagram show that the alignment diagram has good clinical value.
Conclusion A prognostic model for predicting survival in NB patients was constructed based on PRGs, and the accuracy of the model was validated in an overall cohort and test cohort.