bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smokeless Tobacco Consumption and Breast Cancer in Women: Findings of a Case-Control Study
Authors: Mustafa Munmun , Islam Md Ziaul 
Published: October 2023

Background: Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. Among the various risk factors of breast cancer, smokeless tobacco is the neglected potential one. Hence the study was conducted to assess the association between smokeless tobacco consumption & breast cancer risk among the women.
Objective: The objective of the study was to assess the association between smokeless tobacco consumption and breast cancer in women and to compare the pattern of smokeless tobacco consumption, relevant other factors of breast cancer and the socio-demographic characteristics between the cases and controls.
Methods: This case control study was conducted in 302 women of two tertiary hospitals of Dhaka city from January to December’2020. The study enrolled 151 breast cancer patients as cases and another 151 non cancer age-matched women as controls. Convenient technique was used for data collection. A pre-tested semi-structured questionnaire and a checklist were used for face to face interview and to review the medical record respectively. The data were analyzed by SPSS software. Quality control checks of the data were done at all stages of the study. All ethical issues were maintained strictly and informed written consent was taken from each case and control.
Results: The mean (±SD) age of cases and controls was 44.4(±10.56) &44.82(±10.2) years respectively (p=0.769). Maximum cases (90.1%) were married in comparison to controls (76.2%) and the association was significant (p=0.003). Majority of the cases (63.58%) had monthly income of 21000-50000tk compared to controls (51.66%) and this difference was significant (p=0.01).Among the cases, 36.4% were exposed to smokeless tobacco in comparison to 33.8% controls. Though this association was not significant (p=0.630) but maximum cases (70.9%) were found to be exposed for 16-30 years in comparison to controls (43.9%) and it was statistically significant (OR: 7.58, 95%CI: 0.865-66.404). Among the cases, who were exposed to zarda were 3.25 times more likely to have it >10 times in comparison to 2.6% controls (OR: 3.25, 95% CI: 1.05-9.99, p=0.040).
Conclusion: Increased frequency and duration of smokeless tobacco intake is found significantly associated with breast cancer so specific preventive intervention is required for prevention of smokeless tobacco consumption among women to alleviate breast cancer.
Bangladesh Medical Res Counc Bull 2023; 49(2): 83-90
VULNERABILITY ASSESMENT UNTUK MENCARI CELAH KEAMANAN WEB APLIKASI E-LEARNING PADA UNIVERSITAS XYZ
Authors: Aziz Muhammad Aziz 
Published: October 2023

Penelitian ini dilakukan atas dasar perkembangan teknologi informasi dan komunikasi pada saat ini membawa kemudahan bagi kehidupan manusia. Salah satu hal yang berkembang cukup pesat adalah aplikasi berbasis web. Menjamurnya aplikasi berbasis web menjadi tantangan sendiri bagi para pengembang aplikasi berbasis web dalam mengembangkan aspek keamanan. Vulnerability Assesment terhadap web aplikasi E-Learning bertujuan untuk mendeteksi kerentanan, mendeskripsikan kerentanan, menilai kerentanan berdasarkan CVSS (Common Vulnerability Scoring System), dan memberikan solusi. Tahapan penelitian yang digunakan adalah Vulnerability Assesment and Penetration Testing (VAPT) Life Cycle. Dalam mencari kerentanan pada penelitian ini menggunakan nessus vulnerability scanning versi home.Dari hasil vulnerability scanning ditemukan kerentanan critical, kerentanan high, kerentanan medium, dan keretanan low. Pada masing-masing kerentanan tentunya memiliki dampak kerentanan yang berbeda, namun pada kerentanan critical yaitu Elasticsearch Transport Protocol Unspecified Remote Code Execution memiliki dampak yang paling serius dengan base score 9.8, sehingga overall risk level pada Web aplikasi E-Learning adalah High. Jadi dapat disimpulkan Web aplikasi E-Learning pada Universitas XYZ dikatakan rentan, karena memiliki dampak serius yang mempengaruhi Confidentiality, Integrity, dan Availability pada Web Aplikasi E-Learning melalui kerentanan yang dimilikinya. Maka pihak Universitas XYZ harus segera melakukan perbaikan dan evaluasi terhadap keamanan pada Web Aplikasi E-Learning agar resiko kerentanan pada Web Aplikasi E-Learning dapat dikurangi.
Training of Garnish and Carving for The UKM Community in Pacar Kembang Village, Tambaksari District, Surabaya
Authors: Junairiah Junairiah , Wahyuni Dwi Kusuma , Suhargo Listijani 
Published: October 2023

In Pacar Kembang Village, Tambaksari District, Surabaya, there are many SMEs in the culinary sector. The problem with partners is less than optimal sales transactions, a difficult economy and a lack of knowledge to be able to increase purchasing power for this culinary specialty. Therefore, activities need to be carried out to increase people's purchasing power for culinary products produced by the UKM community. One way is to provide training in vegetable garnishing and fruit carving. Through this training activity, the appearance of culinary products can be made more attractive and can increase the selling value of culinary products. So the partner problems that must be addressed are the knowledge and skills aspect as well as the management aspect. The knowledge and skills aspect includes knowledge about selecting garnish ingredients, namely vegetables and carving (fruit) as well as the practice of making garnishes and carving. Management aspects include financial management and digital marketing. In this activity, partners are given training on making garnishes and carvings, applying garnishes and carvings to food products and evaluation is carried out using pre-test and post-test methods. Based on the evaluation results, it shows that the average pre-test score is 80.65; while the post test score was 87.78. This shows that after the training was held there was an increase in participants' knowledge and skills in making garnishes and carving. Keyword: Garnish, carving, UKM, Pacar Kembang
Phytoremediation Using Different Numbers of Individual Kayu Apu Plant (Pistia stratiotes) in Reducing Lead (Pb) Levels in Paper Recycling Factory Waste
Authors: Rahmawati Nurlaili , Lisminingsih Ratna Djuniwati , Prasetyo Hamdani Dwi 
Published: October 2023

Recycled paper mill waste contains inorganic materials, one of heavy metal lead. Metal lead is non-essential and non-degradable that harmful to living things. Reduce lead levels by using Kayu Apu plants (Pistia stratiotes) is needed. The aims, to determine number of Kayu Apu plants that effective in reducing lead levels, temperature and pH of optimum waste according to quality standards, increase in plant's wet weight, and morphological condition of plants. Method is experiment with completely randomized design. Treatment consisted of number of Kayu Apu plants A: control, B: 2 individuals, C: 5 individuals, and D: 9 individuals with 3 replications. Acclimatization of Kayu Apu plant was carried out, measuring physical, chemical and biological parameters, then data were analyzed using one-way ANOVA and paired sample t-test. Results showed that lead levels of treatment using 9 individuals decreased while in control, 2 individuals and 5 individuals increased. Average temperature and pH of waste are still optimum according to quality standards. Average fresh weight of plants increased in treatments B and C, while treatment D decreased. Number of Kayu Apu plants that effective in reducing lead was treatment using 9 individuals. Average temperature and pH of waste were optimum according to quality standards. Wet weight of plants increased in treatments B and C while D decreased. Morphology of Kayu Apu leaves in all treatments turned yellow, dried and fall off but the buds grow.Keywords: Kayu Apu (Pistia stratiotes), lead (Pb), Paper mil waste
Program Penyuluhan Teknologi Pengolahan Pakan Ternak Ruminansia Di Kelurahan Tlogowaru Kedungkandang
Authors: Krisnaningsih Aju Tjatur Nugroho , Leondro Henny , Brihandhono Ari 
Published: October 2023

Tujuan program pengabdian kepada masyarakat (PKM) di Kelurahan Tlogowaru Kedungkandang untuk meningkatkan pengetahuan dan ketrampilan kelompok petani peternak memanfaatkan limbah pertanian menjadi bahan pakan ternak ruminansia yang memiliki nutrisi dan daya cerna yang tinggi, sehingga pada saat musim kemarau, tidak mengalami kesulitan mencari pakan ternak. Target khusus pelaksanaan program yaitu transfer ilmu dan teknologi pembuatan pakan ternak berbasis limbah pertanian. Metode yang dilakukan dalam penyuluhan ini adalah sosialisasi, penyadaran, pelatihan/demplot, pendampingan, monitoring dan evaluasi serta keberlanjutan program. Berdasarkan hasil pelaksanaan kegiatan menunjukkan terdapat peningkatan pengetahuan dan pemahaman serta penguasaan teknik tentang introduksi teknologi pengolahan pakan silase dan amoniasi pada mitra kegiatan. Mitra mampu melaksanakan dan mempraktekkan sendiri seperti yang dicontohkan oleh tim pengabdi dengan benar. Kegiatan program pengabdian pada masyarakat ini dapat mendorong dan mendukung mitra untuk menciptakan dampak yang positip bagi kesejahteraan, kemandirian dan peningkatan produktivitas usaha peternakan.
RANCANG BANGUN SISTEM INFORMASI PENDAFTARAN PROGRAM AYO MENGHAFAL DAN MEMAHAMI AL-QURAN (AMMA) DI YAYASAN IHYAUL QURAN INDONESIA
Authors: Shoumi Milyun Ni’ma , Syulistyo Arie Rachmad , Kirana Annisa Puspa , Hani’ah Mamluatul 
Published: October 2023

Sistem informasi (SI)cadalah salah satu faktor yang penting bagi sebuah instansi yang bergerak di bidang pendidikan. SI memungkinkan instansi untuk lebih produktif dalam memperoleh, memproses, dan menggunakan informasi secara akurat. Salah satu jenis sistem informasi yang dapat membantu proses operasional sebuah instansi di bidang pendidikan adalah Sistem Informasi Pendaftaran untuk program-program yang diselenggarakan oleh lembaga pendidikan. Yayasan Ihyaul Quran merupakan salah satu jenis yayasan pendidikan di Kota Malang yang memiliki beberapa program, diantaranya Program Pendidikan Sekolah Balita, Tahfidz Quran, Kursus Quran, Kuttab Ibadurrahman, dan Ayo Menghafal dan Memahami Al-Quran (AMMA). Saat ini dalam proses pendaftarannya, khususnya program AMMA masih dilakukan secara manual. Kegiatan PKM ini mengusulkan sebuah pengembangan aplikasi dan pelatihan Sistem Informasi Pendaftaran Program Ayo Menghafal dan Memahami Al-Quran (AMMA) di Yayasan Ihyaul Quran Indonesia. Dengan adanya sistem ini diharapkan dapat memudahkan calon peserta dalam melakukan pendaftaran, dan juga memudahkan admin program dalam melakukan pengelolaan data calon peserta.
Allografts for partial meniscus repair: an in vitro and ex vivo meniscus culture study
Authors: Dabaghi Mohammad , Eras Volker , Kaltenhaeuser Daniel , Ahmed Norus , Wildemann Britt 
Published: October 2023

The purpose of this study was to evaluate the treatment potential of a human-derived demineralized scaffold, Spongioflex® (SPX), in partial meniscal lesions by employing in vitro models. In the first step, the differentiation potential of human meniscal cells (MCs) was investigated. In the next step, the ability of SPX to accommodate and support the adherence and/or growth of MCs while maintaining their fibroblastic/chondrocytic properties was studied. Control scaffolds, including bovine collagen meniscus implant (CMI) and human meniscus allograft (M-Allo), were used for comparison purposes. In addition, the migration tendency of MCs from fresh donor meniscal tissue into SPX was investigated in an ex vivo model. The results showed that MCs cultured in osteogenic medium did not differentiate into osteogenic cells or form significant calcium phosphate deposits, although AP activity was relatively increased in these cells. Culturing cells on the scaffolds revealed increased viability on SPX compared to the other scaffold materials. Collagen I synthesis, assessed by ELISA, was similar in cells cultured in 2D and on SPX. MCs on micro-porous SPX (weight &gt;0.5 g/cm3) exhibited increased osteogenic differentiation indicated by upregulated expression of ALP and RUNX2, while also showing upregulated expression of the chondrogen-specific SOX9 and ACAN genes. Ingrowth of cells on SPX was observed after 28 days of cultivation. Overall, the results suggest that SPX could be a promising biocompatible scaffold for meniscal regeneration.
Lower-limb internal loading and potential consequences for fracture healing
Authors: Heyland Mark , Deppe Dominik , Reisener Marie Jacqueline , Damm Philipp , Taylor William R. , Reinke Simon , Duda Georg N. , Trepczynski Adam 
Published: October 2023

Introduction: Mechanical loading is known to determine the course of bone fracture healing. We hypothesise that lower limb long bone loading differs with knee flexion angle during walking and frontal knee alignment, which affects fracture healing success.Materials and methods: Using our musculoskeletal in silico modelling constrained against in vivo data from patients with instrumented knee implants allowed us to assess internal loads in femur and tibia. These internal forces were associated with the clinical outcome of fracture healing in a relevant cohort of 178 extra-articular femur and tibia fractures in patients using a retrospective approach.Results: Mean peak forces differed with femoral compression (1,330–1,936 N at mid-shaft) amounting to about half of tibial compression (2,299–5,224 N). Mean peak bending moments in the frontal plane were greater in the femur (71–130 Nm) than in the tibia (from 26 to 43 Nm), each increasing proximally. Bending in the sagittal plane showed smaller mean peak bending moments in the femur (−38 to 43 Nm) reaching substantially higher values in the tibia (−63 to −175 Nm) with a peak proximally. Peak torsional moments had opposite directions for the femur (−13 to −40 Nm) versus tibia (15–48 Nm) with an increase towards the proximal end in both. Femoral fractures showed significantly lower scores in the modified Radiological Union Scale for Tibia (mRUST) at last follow-up (p &lt; 0.001) compared to tibial fractures. Specifically, compression (r = 0.304), sagittal bending (r = 0.259), and frontal bending (r = −0.318) showed strong associations (p &lt; 0.001) to mRUST at last follow-up. This was not the case for age, body weight, or localisation alone.Discussion: This study showed that moments in femur and tibia tend to decrease towards their distal ends. Tibial load components were influenced by knee flexion angle, especially at push-off, while static frontal alignment played a smaller role. Our results indicate that femur and tibia are loaded differently and thus require adapted fracture fixation considering load components rather than just overall load level.
Significant dysregulation of lipid metabolism in patients with papillary thyroid carcinoma after thyroidectomy
Authors: Zhou Liang , Li Shuo , Wu Yuqi , Chen Qianming , Hu Xiaotong , Jiang Junchang , Shi Yaoyao , Shen Dan , Xie Lei 
Published: October 2023

IntroductionThyroidectomy and thyrotropin suppressive therapy is the widely used surgical treatment for papillary thyroid carcinoma (PTC) patients. However, systematic metabolic changes of post-operative PTC patients were rarely reported.MethodsHere, untargeted metabolomic detection of cohorts from PTC before (t0) and 1-month-after (t1) thyroidectomy, were performed to characterize circulating metabolic signatures after surgical treatment.ResultsOur results showed PTC patients exhibited lower thyroid stimulating hormone degree, higher total thyroxine, and significant lipid-related metabolic alternations after thyroidectomy, which included 97 upregulations (including 93 lipids) and 5 downregulations (including 2 lipids and 3 nucleotides). Enrichment of metabolic pathways mainly included biosynthesis of fatty acids, purine metabolism, and linoleic acid metabolism. We also demonstrated that differential surgical approaches (hemi- and total thyroidectomy) and post-operative complication phenotypes (insomnia, fatigue), might lead to characteristic metabolic signatures.DiscussionThis study revealed dynamic changes of metabolite characteristics of PTC patients after surgical treatment, which were associated with clinical thyroid function parameters, surgical approaches, and complication occurrence. It enlightened us to pay more attention on the post-operative metabolic dysregulation of PTC patients and their long-term qualities of life, so as to provide cautious clinical decisions on surgical choices, treatments, and follow-up details.
A shifting carnivore’s community: habitat modeling suggests increased overlap between the golden jackal and the Eurasian lynx in Europe
Authors: Serva Davide , Iannella Mattia , Cittadino Viviana , Biondi Maurizio 
Published: October 2023

IntroductionThe European large carnivore community is recently showing positive trends. Beyond those, other species are expanding in Europe. In recent decades, the golden jackal (Canis aureus), a medium-sized canid, has rapidly expanded to western and northern Europe, after being historically confined to the Balkans. The Eurasian lynx (Lynx lynx), an apex predator once widely distributed throughout Europe, was nearly eradicated in the 19th century. Recent reintroductions, legal protection, and its natural expansion brought the lynx to recover, though some populations still face extinction. As the carnivores’ community across Europe is rearranging, ecological interactions are changing as well. Indeed, recent observations reported the golden jackal to kleptoparasitize the lynx. Our research aims to predict the potentially suitable habitats for the golden jackal and the Eurasian lynx, detailing the areas where those are expected to coexist soon.MethodsWe model their distribution in Europe for current and future scenarios, using both citizen-science and literature data, using the latter to buffer the possible biases of the former. For this aim, we included not only climatic variables, but also several biotic and abiotic predictors relevant to both species. Moreover, given his strong influence on the golden jackal, we compare our results with the predicted distribution of the grey wolf (Canis lupus).ResultsOur predictions show an increase in habitat suitability for the golden jackal, while an opposite trend is predicted for the Eurasian lynx. Also, we predict the target species to share a large portion of their range in the future, with most of these areas suitable for wolves, too.DiscussionOur results may have several impacts in the context of large-scale management, helping to predict further expansion of the golden jackal, and to identify critical areas for lynx conservation, supporting the management of possible reintroductions, also shedding light on the large carnivores’ changing community
Current biologics in treatment of pemphigus foliaceus: a systematic review
Authors: Carver Caden A. , Kalesinskas Mikole , Ahmed A. Razzaque 
Published: October 2023

BackgroundPemphigus foliaceus (PF) differs from pemphigus vulgaris (PV) in that it affects only the skin and mucous membranes are not involved. Pemphigus is commonly treated with systemic corticosteroids and immunosuppressive agents (ISAs). More recently, biologics have been used. The current literature on biologic therapy often combines treatment of PF with PV, hence it is often difficult for clinicians to isolate the treatment of PF from PV. The purpose of this review was to provide information regarding the use of current biological therapy, specifically in PF.Materials and methodsA search of PubMed, Embase, and other databases was conducted using keywords pemphigus foliaceus (PF), rituximab (RTX), intravenous immunoglobulin (IVIg), and biologics. Forty-one studies were included in this review, which produced 105 patients with PF, treated with RTX, IVIg, or a combination of both. Eighty-five patients were treated with RTX, eight patients with IVIg, and 12 received both RTX and IVIg.ResultsMost patients in this review had PF that was nonresponsive to conventional immunosuppressive therapies (CIST), and had significant side effects from their use. RTX treatment resulted in complete remission (CR) in 63.2%, a relapse rate of 39.5%, an infection rate of 19.7%, and a mortality rate of 3.9%. Relapse was greater in the lymphoma (LP) protocol than the rheumatoid arthritis (RA) protocol (p&lt;0.0001). IVIg led to CR in 62.5% of patients, with no relapses or infections. Patients receiving both biologics experienced better outcomes when RTX was first administered, then followed by IVIg. Follow-up durations for patients receiving RTX, IVIg, and both were 22.1, 24.8, and 35.7 months, respectively.DiscussionIn pemphigus foliaceus patients nonresponsive to conventional immunosuppressive therapy or in those with significant side effects from CIST, RTX and IVIg appear to be useful agents. Profile of clinical response, as well as relapse, infection, and mortality rates in PF patients treated with RTX were similar to those observed in PV patients. The data suggests that protocols specific for PF may produce better outcomes, less adverse effects, and improved quality of life.
Soil microbial community parameters affected by microplastics and other plastic residues
Authors: Li Yüze , Hou Yuting , Hou Quanming , Long Mei , Wang Ziting , Rillig Matthias C. , Liao Yuncheng , Yong Taiwen 
Published: October 2023

IntroductionThe impact of plastics on terrestrial ecosystems is receiving increasing attention. Although of great importance to soil biogeochemical processes, how plastics influence soil microbes have yet to be systematically studied. The primary objectives of this study are to evaluate whether plastics lead to divergent responses of soil microbial community parameters, and explore the potential driving factors.MethodsWe performed a meta-analysis of 710 paired observations from 48 published articles to quantify the impact of plastic on the diversity, biomass, and functionality of soil microbial communities.Results and discussionThis study indicated that plastics accelerated soil organic carbon loss (effect size = −0.05, p = 0.004) and increased microbial functionality (effect size = 0.04, p = 0.003), but also reduced microbial biomass (effect size = −0.07, p &lt; 0.001) and the stability of co-occurrence networks. Polyethylene significantly reduced microbial richness (effect size = −0.07, p &lt; 0.001) while polypropylene significantly increased it (effect size = 0.17, p &lt; 0.001). Degradable plastics always had an insignificant effect on the microbial community. The effect of the plastic amount on microbial functionality followed the “hormetic dose–response” model, the infection point was about 40 g/kg. Approximately 3564.78 μm was the size of the plastic at which the response of microbial functionality changed from positive to negative. Changes in soil pH, soil organic carbon, and total nitrogen were significantly positively correlated with soil microbial functionality, biomass, and richness (R2 = 0.04–0.73, p &lt; 0.05). The changes in microbial diversity were decoupled from microbial community structure and functionality. We emphasize the negative impacts of plastics on soil microbial communities such as microbial abundance, essential to reducing the risk of ecological surprise in terrestrial ecosystems. Our comprehensive assessment of plastics on soil microbial community parameters deepens the understanding of environmental impacts and ecological risks from this emerging pollution.