bluuebunny/crossref_metadata_2025_split huggingface dataset:
A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression
Authors: Tao Xiao , Jing Zheng Wen , Yuan Wang Kui , Yun Guo Hui , Fang Xie Jian , Sheng Liao Ming 
Published: February 2025

ObjectiveThis study compares the safety and effectiveness of theta-burst stimulation (TBS) and repetitive transcranial magnetic stimulation (rTMS) for treating treatment-resistant depression (TRD).MethodsWe reviewed randomized controlled trials (RCTs) that evaluated rTMS and TBS in managing TRD. Searches were conducted in PubMed, Embase, the Cochrane Library, and Web of Science for studies published up to July 31, 2024. Data from these studies were analyzed using statistical software.ResultsFive RCTs involving 1,196 patients were included, with 553 receiving rTMS and 663 receiving TBS. The analysis found no significant differences between rTMS and TBS in reducing depression [SMD = -0.07, 95% CI (-0.19, 0.04)] or anxiety [SMD = -0.02, 95% CI (-0.15, 0.11)], nor in side effects like headaches [OR = 1.00, 95% CI (0.72, 1.40)], nausea [OR = 1.42, 95% CI (0.79, 2.54)], or fatigue [OR = 0.87, 95% CI (0.46, 1.64)].ConclusionsBoth rTMS and TBS are similarly effective in reducing depression and anxiety symptoms, with comparable side effect profiles. However, TBS is more time-efficient, with sessions lasting only 192 seconds, making it a cost-effective option for patients. These findings support TBS as a practical treatment choice for TRD.
Specific endophenotypes in EEG microstates for methamphetamine use disorder
Authors: Gao Xurong , Chen Yun-Hsuan , Zeng Ziyi , Zheng Wenyao , Chai Chengpeng , Wu Hemmings , Zhu Zhoule , Yang Jie , Zhong Lihua , Shen Hua , Sawan Mohamad 
Published: February 2025

BackgroundElectroencephalogram (EEG) microstates, which reflect large-scale resting-state networks of the brain, have been proposed as potential endophenotypes for methamphetamine use disorder (MUD). However, current endophenotypes lack refinement at the frequency band level, limiting their precision in identifying key frequency bands associated with MUD.MethodsIn this study, we investigated EEG microstate dynamics across various frequency bands and different tasks, utilizing machine learning to classify MUD and healthy controls.ResultsDuring the resting state, the highest classification accuracy for detecting MUD was 85.5%, achieved using microstate parameters in the alpha band. Among these, the coverage of microstate class A contributed the most, suggesting it as the most promising endophenotype for specifying MUD.DiscussionWe accurately categorize the endophenotype of MUD into different sub-frequency bands, thereby providing reliable biomarkers.
The complex relationships among self-acceptance, perceived social support, drug use stereotype threat, and subthreshold depression in people with substance use disorder: exploring the mediating and buffering effects
Authors: Li Yongqiu , Wang Rufang , Liu Jun , Li Zuoliang , Zhou Yinghua 
Published: February 2025

IntroductionDepression levels are significantly higher among people with substance use disorder (SUD) than in the general population; however, studies on the level of subthreshold depression in this population are scarce. Research shows a significant correlation between self-acceptance and depression, with social support playing a key role in the process of recovery and social reintegration for people with SUD. This study aimed to explore the effects of self-acceptance, perceived social support, and stereotype threat of people with SUD on their subthreshold depression, as well as potential mediating and buffering effects.MethodsThis study was conducted from January-March 2024. 1068 drug addicts (548 males and 520 females) were recruited in Chengdu, Sichuan Province. After signing informed consent, their psychometric data were obtained using the Self-acceptance Questionnaire (SAQ), Perceived Social Support Scale (PSSS), Drug Use Stereotype Threat Scale (DSTS) and Center for Epidemiologic Studies Depression Scale(CES-D). Gender and group differences in relevant scale dimensions were explored. Linear regression models were used to assess the relationships between PSSS, SAQ, and DSTS scores and subthreshold depression in male and female participants. Bootstrap mediation effect tests were used to further test the mediation effect of drug use stereotype threat and perceived social support between self-acceptance and subthreshold depression. Line graphs were used to show the buffering effect of perceived social support on the relationship between self-acceptance and subthreshold depression in different groups.ResultsThe results showed that,gender, HIV-positive or not, education and monthly income level affect subthreshold depression in patients with SUD. Negative correlation between self-acceptance and subthreshold depression among SUD patients. Furthermore, perceived social support and substance use stereotypes threatmediated the relationship between self-acceptance and subthreshold depression, respectively, forming a parallel mediating relationship. Results exploring the buffering effect of perceived social support by subgroup showed that the buffering effect of perceived social support on subthreshold depression was most pronounced in the HIV-negative and and female groups. Social support, group stereotypes discrimination affect the mental health of sud patients.DiscussionOur study provides theoretical support for the alleviation of subthreshold depression among people with SUD, realizing that self-acceptance, perceived social support and reduction of drug use stereotype threat can be a psychoprotective factor for people with SUD.
Comprehensive health assessment of retired martial arts athletes: bone density, dietary intake, physical activity, and wellbeing
Authors: Alshaer Tasneem , Battikhi Nihad , Amawi Adam Tawfiq , Trabelsi Khalid , Jahrami Haitham , Bouedo Philippe , Ghazzawi Hadeel Ali 
Published: February 2025

Regular physical activity offers benefits like enhanced bone density, which often persists post-retirement. However, retirement can lead to weight gain and changes in quality of life due to reduced physical activity. Therefore, this study investigates the long-term effects of elite athletic experience by comparing retired Jordanian male elite athletes (ages 40–50) with non-athletes of the same age. The differences were explored in weight changes, bone density, quality of life, happiness, stress, insomnia, physical activity, and dietary intake to understand how martial arts impact these health dimensions.MethodsA descriptive case-control study was conducted among 30 retired male elite athletes and 20 age-matched non-athletes. Bone density and body composition were measured using dual-energy X-ray absorptiometry (DEXA) scans. Additional assessments included anthropometric measurements, a 3-day dietary recall, physical activity (International Physical Activity Questionnaire), quality of life (WHOQOL), happiness (Subjective Happiness Scale), stress (Perceived Stress Scale), and insomnia (Insomnia Severity Index).ResultsRetired athletes showed significantly higher Z-scores for the left femur (neck and total) and the AP spine, with p-values &lt;0.05. Among non-athletes, 65% had normal bone density with a Z-score ≥ −1.9 and a T-score &gt; −1.1, 20% had abnormal bone density with a Z-score &lt; −1.9, and 15% had osteopenia with a T-score between −1.1 and −2.4. In contrast, 100% of retired athletes had normal bone density with a Z-score ≥ −1.9 and a T-score &gt; −1.1. Retired athletes exhibited greater weight changes than non-athletes, with a p-value &lt;0.05; the average weight gain among retired athletes was 18.548 kg, and the mean weight gain among non-athletes was 4.3 kg. There were statistically significant mean differences in perceived stress levels between retired athletes and non-athletes with a p-value &lt;0.05. In contrast, there were no statistically significant mean differences between the groups in quality of life, subjective happiness, and the Insomnia Severity Index.ConclusionThe study reveals that retired elite athletes maintain better bone density but face greater weight gain and stress than their non-athlete counterparts. Both groups enjoy a high quality of life and low levels of insomnia. These findings underscore the importance of continued physical activity for health and suggest that both retired athletes and non-athletes should adopt a balanced lifestyle to manage weight and stress effectively.
Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol
Authors: Chmelova Irina , Pastucha Dalibor , Hudecek Tomas , Guran Zdenek , Ciecotkova Sona , Martínek Lubomír , Zubikova Jana , Matlova Alena , Dolezel Jakub , Salounova Dana , Chmelo Jakub 
Published: February 2025

AimsThe concept of prehabilitation, defined as interventions aimed at enhancing a patient's functional capacity prior to an impending physiological stressor, may contribute to reduced postoperative morbidity and mortality. The study's goal is to verify or refute the feasibility of a prehabilitation programme for two diagnostic patient groups during neoadjuvant chemo(radio)therapy, which is prescribed before the scheduled surgical procedure. This is a single group study design, with all patients enrolled receiving the intervention.MethodsThis is an interventional feasibility study of a prehabilitation programme in the form of physical training conducted at home. The training consists of progressively dosed walking and strength exercises for selected muscle groups. Data will be monitored telemetrically and also through telephone contact with participants. Primary outcomes include: the percentage of patients interested in participating in the study out of all patients indicated for neoadjuvant therapy at University Hospital Ostrava during the observed period, the percentage of patients who complete the prehabilitation programme until the date of surgery and individual patient compliance. Secondary outcomes include physical fitness parameters obtained from cardiopulmonary exercise testing, grip strength measured by a dynamometer, changes in body composition, EORTC QLQ-C30 quality of life questionnaire, and a questionnaire on the subjective perception of the exercise programme. Both primary and secondary outcomes will be compared between study arms (two diagnostic groups). The study is registered at ClinicalTrials.gov, ID: NCT05646043.ConclusionThe results of this study can serve as a foundation for larger, multicentre, controlled studies in the future.
The FIT FIRST 10 dose-response study: evaluation of implementation outcomes
Authors: Koch Sofie , Eckert Caroline , Ntoumanis Nikos , Thøgersen-Ntoumani Cecilie , Cimenti Chiara , Larsen Malte Nejst , Krustrup Peter , Skov Christiansen Lars Breum 
Published: February 2025

IntroductionIncreasing physical activity (PA) levels among children is critical to mitigate health risks associated with physical inactivity. Schools have been highlighted as ideal setting for promoting PA. However, existing school-based PA programs often face implementation challenges. The FIT FIRST 10 (FF10) multi-sport program has been introduced in Denmark, aiming to increase PA and to enhance children's health, fitness, and well-being. This study evaluates the implementation of the FF10 program for 2nd and 3rd graders.Materials and methodsThe FF10 program was implemented in a 20-week cluster randomized controlled trial across 27 schools. Schools were assigned to a control arm or intervention arms receiving either 3 (full dose) or 1.5 (half dose) FF10 40-min lessons weekly. Teachers received a one-day training session, comprehensive manuals, and necessary equipment. Data were collected from teachers via logbooks documenting implementation fidelity, and an online questionnaire assessing program acceptability, appropriateness, and feasibility, and teachers' capability, opportunity, and motivation for implementing the FF10 program.ResultsA total of 18 intervention schools with 36 classes participated in this study. Program fidelity was high in both intervention groups (2.8 and 2.0 session/week for full and half-dose, respectively). Confidence intervals indicated no differences between the two intervention groups for any outcomes. Teachers (n = 32) in both groups rated FF10 moderately acceptable, appropriate, and feasible (3.5–4.0 out of a potential maximum of 5). Both groups exhibited moderate physical and psychological capabilities (3.5–4.0) and high social opportunities (&gt;4.0), but poor motivation scores (&lt;3.5), particularly regarding the perceived benefits and automatization in delivering the FF10 program.ConclusionThe FF10 program was almost delivered as intended, but time constraints, limited facilities, and modest teacher motivation might have hindered implementation. Reducing the program's dosage did not improve implementation outcomes, emphasizing the need for ongoing support to boost teacher motivation and integration of the program into school timetables.
Analgesic efficacy of hydromorphone in American alligators (Alligator mississippiensis)
Authors: Henke Scott E. , Wester David B. , Eversole Cord B. , Huerta Javier O. , Hilton Clayton D. , Sladky Kurt K. 
Published: February 2025

BackgroundAmerican alligators (Alligator mississippiensis) are maintained in zoos, aquaria, and farms for educational, research, and production purposes. The standard of veterinary medical care and welfare for captive reptiles requires managing pain and discomfort under conditions deemed painful in mammals. While analgesic efficacy and pharmacokinetic data for several reptile species are published, data with respect to analgesic efficacy in crocodilians are clearly lacking.ObjectiveThe objective of this study was to determine the analgesic efficacy of hydromorphone in alligators.MethodsFemale American alligators (N = 9; 57 months of age) were exposed to mechanical noxious stimuli at multiple anatomic sites using von Frey filaments ranging in size from 1.65 to 6.65 grams-force, and their behavioral reactions recorded. In order to evaluate analgesic efficacy, hydromorphone (0.5 mg/kg SC) was administered in the axillary region to the same alligators and the mechanical noxious stimuli were repeated and behaviors recorded.ResultsAdministration of hydromorphone contributed to a range from 62 to 92% reduced avoidance reactions to mechanical noxious stimuli for two anatomic sites (i.e., naris and lateral mandible, respectively).ConclusionAlligators did not appear to experience clinically relevant respiratory depression, hypothermia, or other adverse reactions. Therefore, hydromorphone shows promise as an analgesic option to be administered under painful conditions in American alligators.
Regional blood flow in dental patients with reduced interalveolar distance and auditory disorders (Part 2)
Authors: Gaivoronskaya A. A. , Tsimbalistov A. V. , Voityatskaya I. V. , Lopushanskaya T. A. , Gaivoronskaya M. G. , Chernogaeva E. A. , Solovykh E. A. 
Published: February 2025

Relevance. Reduced interalveolar distance, resulting from increased wear of dental hard tissues, generalized periodontitis, and tooth loss, leads to morphofunctional changes not only in the masticatory muscles and temporomandibular joint (TMJ) but also in other structures of the maxillofacial region. These changes affect hemodynamics in the vascular regions of the face, neck, brain, TMJ, and upper cervical spine. Objective. To evaluate regional blood flow in dental patients with reduced interalveolar distance and auditory disorders.Materials and methods. The study was conducted on a group of patients with signs of reduced interalveolar distance (n = 50), aged 34 to 73 years, with a mean age of 53.5 ± 2.4 years. The group comprised 22 men (44.0%) and 28 women (56.0%). The examination included the functional-physiological method for determining the central relationship of the jaws using the Apparatus for Determining Central Occlusion (AOTSO) and duplex ultrasound scanning of the head, neck, and TMJ vessels.Results. In patients with reduced interalveolar distance in habitual occlusion, a high asymmetry coefficient of linear blood flow velocity was observed in the examined arteries, reaching up to 40%, along with signs of venous dysgemia. Using loading tests during the functional-physiological method achieved optimal positioning of the mandibular condyles in the mandibular fossa and optimized occlusion. This significantly reduced the blood flow asymmetry coefficient to 4%, with no signs of venous outflow disorders. These improvements indirectly influenced the hemodynamics of the peripheral auditory system, enhancing its function. Conclusion. reduced interalveolar distance, temporomandibular joint, auditory disorders.
Uptake of Peritoneal Dialysis (PD) by Minoritized Patients
Authors: Arnaoudova Ivelina , Wilson Clara , Rizzolo Katherine , Shen Jenny , Ehtesham Nahian , Wilson Jennifer , Golestaneh Ladan 
Published: February 2025

Background:
In a cohort of patients with late-stage kidney disease who completed dialysis modality education and who self-identified as racial ethnic minorities, we studied characteristics of those choosing PD, and perception of usefulness of the education session in modality selection.

Methods:
In this study of individuals with kidney failure cared for by nephrologists at Montefiore Medical Center, Bronx, NY, who were referred for modality education, we: 1-tested the association of patient characteristics with modality selection in 113 patients from 2021-2023, and 2-examined patient perception of the quality of modality education from 13 semi-structured interviews. We compared sociodemographic, clinical attributes, and patient responsiveness to attempts made by staff among those who selected and initiated PD to those who a-did not select PD, or b-initiated on HD urgently . We performed qualitative analysis of interviews to reach consensus on theoretical domain framework concepts and how they fit events in the kidney failure trajectory.

Results:
Compared to individuals who required urgent HD, those who selected, and were initiated on, PD were younger (54 yrs vs 66 yrs), had fewer comorbidities, and did not require as many attempts to schedule modality education. Qualitative analysis of interviews showed that experience with staff and quality of information conveyed during education was generally positive, but the following gaps were identified: lack of support for the emotional trauma of kidney failure diagnosis, inability to address structural barriers to PD specific to the patient population, and the lack of a deliberate program to lessen anxiety about the responsibility of PD.

Conclusions:
Incorporation of tailored content that addresses clinical comorbidity, structural barriers to care and emotional trauma constitute aspects of modality education that can be improved to increase PD uptake among minoritized patients.
ІННОВАЦІЙНА ДІЯЛЬНІСТЬ ЯК ОБ'ЄКТ УПРАВЛІННЯ ТРАНСПОРТНОЮ СИСТЕМОЮ УКРАЇНИ
Authors: Костенюк Наталія , Костенюк Катерина 
Published: February 2025

У статті розглянуто інноваційна діяльність як об'єкт управління транспортною системою України. Наголошено на її ролі у підвищенні ефективності функціонування транспортної галузі, її здатності швидко та ефективно адаптуватися до сучасних глобальних викликів і тенденцій, а також у забезпеченні сталого, довготривалого розвитку. Автори акцентують увагу на нагальній необхідності впровадження сучасних, передових технологій, активізації процесів цифровізації, оптимізації та модернізації управлінських підходів, а також імплементації та гармонійної інтеграції кращого європейського досвіду в національну практику. Підкреслюється, що інноваційна діяльність є не просто одним із факторів, а основним рушієм модернізації транспортної інфраструктури, підвищення конкурентоспроможності галузі на міжнародному рівні та зміцнення економіки України в цілому. У статті акцентовано увагу на першочерговій важливості впровадження інноваційних технологій для модернізації транспортної інфраструктури та підвищення ефективності роботи транспорту в країні. Дослідженням виявлено, що інноваційні процеси здатні не тільки значно покращити основні економічні показники, але й вплинути на екологічну та соціальну складові, забезпечуючи, таким чином, стійкість і поступальний розвиток транспортної системи. Для досягнення цих амбітних цілей необхідно ретельно та зважено організувати управлінські механізми, орієнтуючи їх на сучасні світові тенденції та новітні технологічні досягнення, що дозволить максимально ефективно використовувати потенціал інновацій.
У статті детально розглядається саме поняття інноваційної діяльності, як невід'ємного аспекту управління транспортною системою України, оскільки вона є каталізатором модернізації інфраструктури, значного підвищення ефективності та безпеки транспортних перевезень, як пасажирських, так і вантажних. Впровадження нових технологій і прогресивних підходів дозволяє ефективно вирішувати наявні проблеми, такі як критичне перенавантаження доріг, значне погіршення стану навколишнього середовища, а також сприяє оптимізації складних логістичних процесів. Для успішної реалізації інноваційних ініціатив та досягнення бажаного результату необхідно комплексно підходити до формування стратегії розвитку транспортної галузі, обов'язково враховуючи економічні, соціальні та екологічні фактори. Це, в свою чергу, вимагає високого рівня узгодженості та ефективної взаємодії між державними структурами, представниками бізнесу та науковими установами, що є запорукою стабільного зростання та гармонійного розвитку транспортної галузі України в довгостроковій перспективі.
Polityka historyczna a propaganda polityczna
Authors: Opulski Rafał 
Published: February 2025

DEFINICJA POJĘCIA: Polityka historyczna pozostaje w złożonej relacji z propagandą polityczną rozumianą jako zorganizowane i świadome wywieranie informacyjno-manipulacyjnego wpływu na odbiorcę, by ten postrzegał rzeczywistość i zachowywał się zgodnie z intencjami nadawcy działającego na zlecenie depozytariuszy władzy bądź osób aspirujących do jej sprawowania.
ANALIZA HISTORYCZNA POJĘCIA: Początkowo propagandę rozumiano jako działalność reklamowo-polityczną, która nie denotowała pejoratywnych asocjacji. Dopiero z czasem kojarzono ją coraz częściej z totalitaryzmem i autorytaryzmem. Współcześnie, by zwiększyć skuteczność oddziaływania, propagandyści unikają używania tego terminu.
UJĘCIE PROBLEMOWE POJĘCIA: W systemach niedemokratycznych, gdzie historia jest instrumentalizowana przez władzę, następuje zrównanie propagandy politycznej z polityką historyczną. W krajach demokratycznych krytycy polityki historycznej, zarzucając jej manipulację i fałszowanie przeszłości, de facto utożsamiają ją z propagandą polityczną.
REFLEKSJA SYSTEMATYCZNA Z WNIOSKAMI I REKOMENDACJAMI: Prawidłowo prowadzona polityka historyczna w państwach demokratycznych nie jest propagandą polityczną. Warunkami jej skuteczności jest umiarkowanie i konsensus w wymiarze wewnętrznym, a zewnętrznym – odwoływanie się do wartości innych narodów i wspólnot.