bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastatic prostatic adenocarcinoma presenting as generalized lymphadenopathy unmasked by a COVID booster vaccine
Authors: Bharathidasan Kavya , Tran Vivie , Ghafouri Sayed Reshad , Rehman Shabnam , Brandi Luis 
Published: November 2023

Key Clinical MessageLymphadenopathy following recent immunization is usually regional. Generalized lymphadenopathy should arouse suspicion for alternative underlying pathology. Prostate adenocarcinoma should be considered in the differential diagnosis for malignancy in an elderly male patient. Metastatic prostate adenocarcinoma can have good prognostic outcomes if treatment is started promptly, even in the setting of widespread disease.AbstractGeneralized lymphadenopathy is commonly attributed to infectious causes or malignancy, often lymphoproliferative disorders. We present a rare case of metastatic prostate cancer diagnosed after initially presenting as generalized lymphadenopathy following a coronavirus disease 2019 (COVID) booster vaccination. A 70‐year‐old Hispanic male presented with left lower quadrant abdominal pain, nausea, headache, myalgia, severe constipation, and a right‐sided neck swelling that had been increasing in size since the day of his vaccination. Computed tomography (CT) scans of soft tissue neck, chest, abdomen, and pelvis with contrast showed extensive lymphadenopathy. Ultrasound‐guided biopsy results of the enlarged right supraclavicular node and prostate revealed histopathology consistent with that of prostate acinar adenocarcinoma. He started on bicalutamide for 4 weeks, transitioned to gonadotropin releasing hormone analogue (leuprolide) injections every 3 months and oral androgen receptor signaling inhibitor (abiraterone with prednisone daily). PSA level declined from 121 ng/mL at diagnosis to 1.3 ng/mL after 3 months of therapy, and repeat imaging showed marked improvement in the size of his mediastinal, retroperitoneal, and pelvic lymphadenopathy. To the best of our knowledge, this is the first case reported of a COVID vaccine booster uncovering lymphadenopathy leading to the diagnosis of metastatic prostate cancer.
Hybrid Membrane Composed of Nickel Diselenide Nanosheets with Carbon Nanotubes for Catalytic Conversion of Polysulfides in Lithium‐Sulfur Batteries
Authors: Liu Hongtao , Ma Chao , Zhang Cuijuan , Zhang Wenwen , Deng Yuge , Sun Huayu , Shen Xiangqian , Yao Shanshan 
Published: November 2023

AbstractLithium‐sulfur batteries demonstrate enormous energy density are promising forms of energy storage. Unfortunately, the slow redox kinetics and polysulfides shuttle effect are some of the factors that prevent the its development. To address these issues, the hybrid membrane with combination of nickel diselenide nanosheets modified carbon nanotubes (NSN@CNTs) and utilized Li2S6 catholyte for lithium sulfur battery. The conductive CNTs facilitates fast electronic/ionic transport, while the polarity of NSN as a strong affinity to lithium polysulfides, effectively anchoring them, facilitating the redox conversion of polysulfide species, and effectively diminishing reaction barriers. The cell with NSN@CNTs delivers the first discharge capacity of 1123.8 mAh g−1 and maintains 786.5 mAh g−1 after 300 cycles (0.2 C) at the sulfur loading 5.4 mg. Its rate capability is commendable, enabling it to sustain a capacity of 559.8 mAh g−1 even at a high discharge rate of 2 C. In addition, its initial discharge capacity can remain 8.33 mAh even at 10.8 mg for duration of 100 cycles. This research indicates the potential application of NSN@CNTs hybrid materials in lithium‐sulfur batteries.
Activated Mn‐MACHO Complexes Form Stable CO2 Adducts
Authors: Singh Ajeet , Kemper Gregor , Weyhermüller Thomas , Kaeffer Nicolas , Leitner Walter 
Published: November 2023

AbstractManganese(I) carbonyl complexes bearing a MACHO‐type ligand (HN(CH2CH2PR2)2) readily react in their amido form with CO2 to generate 4‐membered {Mn−N−C−O} metallacycles. The stability of the adducts decreases with the steric demand of the R groups at phosphorous (R=isopropyl>adamantyl). The CO2‐adducts display generally a lower reactivity as compared to the parent amido complexes. These adducts can thus be interpretated as masked forms of the active amido catalysts and potentially play important roles as off‐loop species or branching points in catalytic transformations of carbon dioxide.
Detecting Protein‐Ligand Interactions with Nitroxide Based Paramagnetic Cosolutes
Authors: Penk Anja , Danielsson Annemarie , Gaardløs Margrethe , Montag Cindy , Schöler Andrea , Huster Daniel , Samsonov Sergey A. , Künze Georg 
Published: November 2023

AbstractNMR spectroscopy techniques can provide important information about protein‐ligand interactions. Here we tested an NMR approach which relies on the measurement of paramagnetic relaxation enhancements (PREs) arising from analogous cationic, anionic or neutral soluble nitroxide molecules, which distribute around the protein‐ligand complex depending on near‐surface electrostatic potentials. We applied this approach to two protein‐ligand systems, interleukin‐8 interacting with highly charged glycosaminoglycans and the SH2 domain of Grb2 interacting with less charged phospho‐tyrosine tripeptides. The electrostatic potential around interleukin‐8 and its changes upon binding of glycosaminoglycans could be derived from the PRE data and confirmed by theoretical predictions from Poisson‐Boltzmann calculations. The ligand influence on the PREs and NMR‐derived electrostatic potentials of Grb2 SH2 was localized to a narrow protein region which allowed the localization of the peptide binding pocket. Our analysis suggests that experiments with nitroxide cosolutes can be useful for investigating protein‐ligand electrostatic interactions and mapping ligand binding sites.
Analysis of the high‐pressure steam import behaviour of an integrated ethylene oxide/ethylene glycol petrochemical plant under different production scenarios
Authors: Sharifara Ehsan , Abbaspour Madjid , Saraei Alireza 
Published: November 2023

AbstractIntegrated ethylene oxide/ethylene glycols (EO/EG) plants are prominent energy consumers in the petrochemical sector, particularly concerning high‐pressure steam (HPS) usage which holds the potential for substantial energy savings. This study focuses on an unexplored territory: Examining the impact of EO catalyst type, selectivity, and glycols production capacity on HPS import in a plant in the Pars Special Economic Energy Zone (PSEEZ). Utilizing Python3 for data preprocessing and ordinary least squares linear regression analysis, we evaluate how varying catalyst loads and production scenarios influence HPS import. Regression models are created, encompassing normal and efficient HPS import scenarios, yielding positive outcomes in terms of correlation, mean error percentage, and R2 analysis. Comparing normal and efficient HPS import models highlights potential savings, uncovering opportunities to conserve between 45 and over 200 tonnes per day of HPS. We also explore the plant's HPS behaviour under 1% selectivity and production capacity reductions. Notably, catalyst activity decline markedly escalates HPS import for hybrid catalysts, while selectivity decline decreases HPS import for high‐activity catalysts. The models demonstrate that HPS import is ~150 tonnes per day more sensitive to a 1% change in selectivity compared to production capacity. Moreover, when comparing high activity and hybrid catalyst scenarios in normal and efficient cases, the most substantial HPS import difference arises under conditions of low selectivity, amounting to nearly 200 tonnes per day. Our methodology applies to other EO/EG plants. It is incorporated into our plant's energy management system, enabling continuous monitoring of steam import behaviour relative to catalyst and plant performance.
Prognosis and risk of suicide after cancer diagnosis
Authors: Kinslow Connor J. , Kumar Prashanth , Olfson Mark , Wall Melanie M. , Petridis Petros D. , Horowitz David P. , Wang Tony J. C. , Kachnic Lisa A. , Cheng Simon K. , Prigerson Holly G. , Yu James B. , Neugut Alfred I. 
Published: November 2023

AbstractIntroductionSuicide rates are elevated after cancer diagnosis. Existential distress caused by awareness of one’s impending death is well‐described in patients with cancer. The authors hypothesized that suicide risk is associated with cancer prognosis, and the impact of prognosis on suicide risk is greatest for populations with higher baseline suicide risk.MethodsThe authors identified patients (≥16 years old) with newly diagnosed cancers from 2000 to 2019 in the Surveillance, Epidemiology, and End Results database, representing 27% of US cancers. Multiple primary‐standardized mortality ratios (SMR) were used to estimate the relative risk of suicide within 6 months of diagnosis compared to the general US population, adjusted for age, sex, race, and year of follow‐up. Suicide rates by 20 most common cancer sites were compared with respective 2‐year overall survival rates (i.e., prognosis) using a weighted linear regression model.ResultsAmong 6,754,704 persons diagnosed with cancer, there were 1610 suicide deaths within 6 months of diagnosis, three times higher than the general population (SMR = 3.1; 95% confidence interval, 3.0–3.3). Suicide risk by cancer site was closely associated with overall prognosis (9.5%/percent survival deficit, R2 = 0.88, p < .0001). The association of prognosis with suicide risk became attenuated over time. For men, the risk of suicide increased by 2.8 suicide deaths per 100,000 person‐years (p < .0001) versus 0.3 in women (p < .0001). The risk was also higher for persons ≥60 old and for the White (vs. Black) race.ConclusionsPoorer prognosis was closely associated with suicide risk early after cancer diagnosis and had a greater effect on populations with higher baseline risks of suicide. This model highlights the need for enhanced psychiatric surveillance and continued research in this patient population.
Effectiveness of perioperative oral hygiene management using a cetylpyridinium chloride‐, dipotassium glycyrrhizinate, and tranexamic acid‐based mouthwash as an adjunct to mechanical oral hygiene in patients with maxillomandibular fixation: A randomized controlled clinical trial
Authors: Aijima Reona , Yamashita Yoshio 
Published: November 2023

AbstractObjectivesMaxillomandibular fixation requires the jawbones to remain static. Mechanical cleaning is also carried out by brushing or with a water flosser to maintain the oral cavity in a hygienic state, but this cannot be considered sufficient. Mouthwashes are used as a substitute for mechanical cleaning or in a supplementary role after such cleaning. The aim is to evaluate the effectiveness of HABITPRO mouthwash, which contains cetylpyridinium chloride, dipotassium glycyrrhizinate, and tranexamic acid in the specific environment created by maxillomandibular fixation used as an adjunct to mechanical cleaning.Material and MethodsA total of 55 patients who had undergone maxillomandibular fixation were randomly allocated to either a HABITPRO group (n = 29) or a placebo group (n = 26). To investigate their oral hygiene status, their plaque control record (PCR) was reviewed, and the caries‐related bacterial counts, pH, acid buffering capacity, white blood cell count, and ammonia in saliva were measured immediately before maxillomandibular fixation, on Day 10 of fixation, and immediately after fixation was released.ResultsAfter approximately 2–3 weeks of mouthwash use, the PCR index also increased significantly in the placebo group compared with baseline, whereas it remained almost steady in the HABITPRO group. Additionally, salivary ammonia levels decreased significantly in the HABITPRO group compared to that of the placebo group.ConclusionsEven with maxillomandibular fixation, continued gargling with HABITPRO mouthwash in the perioperative period as an adjunct to mechanical cleaning can help maintain better oral hygiene and reduce bacterial counts.
Revisiting the nexus between corporate social responsibility and corporate value: Evidence from China
Authors: Wu Jing , Liew Chee Yoong 
Published: November 2023

AbstractPurposeUnder the concept of sustainable development guided by ‘carbon peak’ and ‘carbon neutral’, corporate social responsibility (CSR) performance has become the focus of attention in all sectors of society. With the gradual deepening of China's ‘new economic normal’ development, firms face increasing environmental uncertainty in the market. This study aims to embed CSR, financial flexibility (FF), institutional investors (INST), and corporate value into the same theoretical framework and conduct heterogeneity analysis on the nature of property rights, heavily polluting industries, and marketisation level.Design/Methodology/ApproachBased upon the observation data of listed firms in Shanghai and Shenzhen A‐shares in China from 2011 to 2021, this study uses Stata software for data processing, analysis, and two‐stage least‐squares (2SLS) models to solve endogenous problems.FindingsThe research results show that improving CSR performance increases corporate value, while INST and FF moderate the relationship between them. Further heterogeneity analysis found that the nature of property rights, heavily polluting industries, and marketisation level have different impacts on these moderating effects. This result provides ideas for clarifying the economic impact of enhancing the firms' CSR performance in the current era.Originality/ValueFirst, from the standpoint of CSR performance, it enhances the literature on the key corporate values in China. Second, from the perspective of corporate value, it has enriched the CSR literature and provided a new perspective for further clarifying the significance of improving the CSR performance of firms at this stage. Third, from the perspective of INST and FF, this research examines the moderating mechanism of CSR performance on corporate value. Hence, it provides a reference for further improving the efficiency of resource allocation in the capital markets.
Molecular testing of cytology specimens: Issues in specimen adequacy and clinical utility
Authors: Ghous Ghulam , Ijaz Komal , Esebua Magda , Layfield Lester J. 
Published: November 2023

AbstractBackgroundNext generation sequencing (NGS) is standard of care for workup of many neoplasms including adenocarcinomas of the lung. Molecular testing of cytology samples is used for many types of neoplasms but the value of such testing for the selection of “first”‐ and “second‐line” treatment protocols is incompletely understood.MethodsFifty‐six sequentially performed cytology specimens (49 fine needle aspirates and 7 fluids) submitted for molecular analysis were reviewed by a medical oncologist to determine specimen adequacy and utility of results for therapy selection. Chart review was performed to determine availability of microsatellite instability status, tumor mutational burden, and presence of driver mutations treatable with targeted therapy in a “first”‐ or “second‐line” application.ResultsForty of 56 cases were successfully sequenced and 34% (19/56) had targetable mutations detected by NGS. Ten of these 19 cases (53%) received targeted therapy for their tumor type with five of 10 patients receiving “first‐line” therapy and five (50%) “second‐line” therapy. Twenty‐two mutations were detected where no targeted therapy for the patient's tumor type existed but targeted therapies were available for other tumor types. Of these specimens, only one patient received treatment using protocols associated with a second tumor type. Total mutation burden and microsatellite instability status results were obtained in 29 of 56 cases (52%).Conclusions71% (40/56) of cytologic specimens were adequate for sequencing with 34% (19/56) demonstrating a targetable mutation and 53% of these patients receiving therapy targeted to the driver mutation of their tumor type.
I2/CAN as a Mild and Efficient Reagent for Oxidative Csp3‐Csp2 Cleavage of 3,3′‐Bis‐7‐azaindolylmethane: A Rapid One‐Pot Access to 3‐Formyl and 3‐Iodo‐7‐azaindoles
Authors: Elavarasan Pavithra , Kannadasan Sathananthan , Shanmugam Ponnusamy 
Published: November 2023

AbstractThe combination of I2/CAN has emerged as a mild and powerful reagent for the oxidative Csp3‐Csp2 cleavage of 3,3′‐bis‐7‐azaindolylmethane to provide a quantitative combined yield of 3‐formyl and 3‐iodo‐7‐azaindole in a one‐pot reaction at RT. A plausible mechanism and characterization, including XRD, has been described. The synthetic transformations of title compounds were explored by reduction, Click, reductive amination, and Suzuki coupling reaction.
The game of energy transition: A game theoretical perspective on public participation procedures in infrastructure planning
Authors: Ruffing Eva , Brendler Viktoria 
Published: November 2023

AbstractFor energy transition, infrastructure construction is often indispensable but also contested and potentially problematic for social cohesion. Through a game theoretical lens, we examine the basic configuration of infrastructure conflicts. Informed by the empirical example of German electricity grid planning, we discuss three approaches to resolve multilevel infrastructure conflicts, (1) technocratic decision‐making, (2) participatory decision‐making, and (3) redistribution and compensation, as well as the conditions under which we can expect them to mitigate conflicts. Each of the three approaches has been tried out in German grid planning over time, which allows us to analyze whether the respective conditions were met and why the approaches were (not) able to resolve existing conflicts. We demonstrate that enduring conflicts in German grid expansion are not caused by a fundamentally ill‐defined decision‐making procedure but rather by a particularly “wicked” conflict structure that can hardly be resolved within planning procedures.
The levels of vitamins and cytokines in serum of elderly patients with community‐acquired pneumonia: A case–control study
Authors: Jing Yongfa , Chen Lingling , Geng Linna , Shan Zhaofei , Yang Juling 
Published: November 2023

AbstractBackground and AimsThe community acquired pneumonia (CAP) is a common disease with high incidence rate and mortality among the elderly. This study aims to explore the association between vitamins, cytokines, and CAP infected by different pathogens in Handan First Hospital.MethodsThe subjects of this study were elderly patients with community‐acquired pneumonia in Handan First Hospital and healthy elderly people in the community from February 2018 to December 2019. The study include 234 CAP patients and 180 healthy elderly people. The differences between the healthy and CAP groups were analyzed by blood routine test, urine routine test, Liquid chromatography tandem mass spectrometry (LC‐MS/MS) detection of vitamin level, and Enzyme linked immunosorbent assay (ELISA) detection of cytokine level. Sputum culture was used to detect pathogens.ResultsAccording to our results, there was no significant difference in the contents of vitamin A, vitamin D, vitamin E, and vitamin C in serum between the healthy and CAP elderly. However, compared with the control group, the levels of serum cytokines of IL‐2, IL‐17, and TGF‐β in the CAP patients were significantly increased. In addition, IL‐17 was positively correlated with white blood cells, neutrophils, platelet/lymphocyte ratio and neutrophil/lymphocyte ratio of CAP patients, and negatively correlated with lymphocytes. The four pathogens with the highest positive rates were Streptococcus pneumoniae, Klebsiella pneumoniae, Mycoplasma pneumoniae and H. influenza. In patients with S. pneumoniae infection, the IL‐2, IL‐17, and TGF‐β levels were significantly higher than the levels in the control group; IL‐17 was also significantly increased in the serum of patients infected with M. pneumoniae, K. pneumoniae, and H. influenza.ConclusionsThere is no direct association between vitamins in serum and community acquired pneumonia (CAP). However, the cytokines are closely related to the clinical indicators and pathogens of CAP patients, which can provide references for the diagnosis, prognosis and treatment of CAP patients.
Evaluating the effects of climate change and chemical, physical, and biological stressors on nearshore coral reefs: A case study in the Great Barrier Reef, Australia
Authors: Mentzel Sophie , Nathan Rory , Noyes Pamela , Brix Kevin V. , Moe S. Jannicke , Rohr Jason R. , Verheyen Julie , Van den Brink Paul J. , Stauber Jennifer 
Published: November 2023

Abstract
An understanding of the combined effects of climate change (CC) and other anthropogenic stressors, such as chemical exposures, is essential for improving ecological risk assessments of vulnerable ecosystems. In the Great Barrier Reef, coral reefs are under increasingly severe duress from increasing ocean temperatures, acidification, and cyclone intensities associated with CC. In addition to these stressors, inshore reef systems, such as the Mackay–Whitsunday coastal zone, are being impacted by other anthropogenic stressors, including chemical, nutrient, and sediment exposures related to more intense rainfall events that increase the catchment runoff of contaminated waters. To illustrate an approach for incorporating CC into ecological risk assessment frameworks, we developed an adverse outcome pathway network to conceptually delineate the effects of climate variables and photosystem II herbicide (diuron) exposures on scleractinian corals. This informed the development of a Bayesian network (BN) to quantitatively compare the effects of historical (1975–2005) and future projected climate on inshore hard coral bleaching, mortality, and cover. This BN demonstrated how risk may be predicted for multiple physical and biological stressors, including temperature, ocean acidification, cyclones, sediments, macroalgae competition, and crown of thorns starfish predation, as well as chemical stressors such as nitrogen and herbicides. Climate scenarios included an ensemble of 16 downscaled models encompassing current and future conditions based on multiple emission scenarios for two 30-year periods. It was found that both climate-related and catchment-related stressors pose a risk to these inshore reef systems, with projected increases in coral bleaching and coral mortality under all future climate scenarios. This modeling exercise can support the identification of risk drivers for the prioritization of management interventions to build future resilient reefs. Integr Environ Assess Manag 2024;20:401–418. © 2023 Norwegian Institute for Water Research and The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC). This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.