bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing of Acute Pediatric Cough in Africa: prescription of Cough Suppressants and Associated Complications
Authors: Mbiya Benoît Mukinayi , Mbuyi Denis Kalambayi , Kasongo Steve Tshiala , Daubie Valery 
Published: December 2023

Background: The use of antitussives is a crucial issue in pediatrics and can lead to respiratory complications that can affect the prognosis.
Objectives: to determine the frequency of respiratory complications associated with the use of an-titussives in pediatrics in a remote city in the Democratic Republic of Congo.
Method: This is a cross-sectional retrospective study conducted between January 1, 2017 and De-cember 2022. Patients under 12 years of age with an acute cough were eligible. The parameters studied were treatment with cough suppressants and associated respiratory complications.
Results: A total of 218 children suffered from an acute cough. The average age was 11 months 10, the sex ratio (H/F) was 126/92. In 30% of cases, children were treated with cough suppressants for an average of 7 days prior to admission. Respiratory complications were observed in 11% (23/218) of cases. The majority of these complications, 61% (14 of 23), had received antitussive treatment prior to hospitalization. Respiratory complications were associated with cough medications (p-value = 0.0012, relative risk (RR) = 3.66, IC90 [1.696; 7,873]). Acute respiratory distress was reported in 87% (20/23) of cases and was associated with the use of cough suppressants (p-value = 0.0065, RR: 3.060, IC90: [1.433; 6,485]).
Conclusion: The use of antitussives in pediatrics poses a risk of acute respiratory distress in a remote city that does not have sufficient human and material resources for management.
Keywords: cough, cough suppressants, pediatrics, complications, Mbujimayi, Democratic Republic of Congo.
Uterine Fibroid prevalence in a predominantly Black, Chicago-Based Cohort
Authors: Ndebele Sithembinkosi , Turner Tecora , Liao Chuanhong , Aschebrook-Kilfoy Briseis , Randorf Nina , Ahsan Habibul , Odunsi Kunle , Madueke-Laveaux Obianuju Sandra 
Published: December 2023

ABSTRACT
Objectives: To investigate the effect of individual-level, neighborhood, and environmental variables on uterine fibroid (UF) prevalence in a Chicago-based cohort.
Methods: Data from the Chicago Multiethnic Prevention and Surveillance Study (COMPASS) were analyzed. Individual-level variables were obtained from questionnaires, neighborhood variables from the Chicago Health Atlas, and environmental variables from NASA satellite ambient air exposure levels. The Shapiro-Wilks test, logistic regression models, and Spearman’s correlations were used to evaluate the association of variables to UF diagnosis.
Results: We analyzed 602 participants (mean age: 50.3±12.3) who responded to a question about UF diagnosis. More Black than White participants had a UF diagnosis (OR, 1.32; 95% CI, 0.62–2.79). We observed non-significant trends between individual-level and neighborhood variables and UF diagnosis. Ambient air pollutants, PM2.5 and DSLPM were protective against UF diagnosis (OR 0.20, CI: 0.04–0.97: OR 0.33, CI: 0.13–0.87).
Conclusions: Associations observed within a sample in a specific geographic area may not be generalizable and must be interpreted cautiously.
In and Out Beauty and Sensitive Skin, a Psychophysiological Exploration: Myth or Reality?
Authors: Falcao Leila , Kappes Rachida Nachat , Filaire Edith 
Published: December 2023

Knowing that biomolecules, such as β-amyrin and α-amyrin, have some pharmacological effects, the aim of this study was directed towards exploring the protective effect of a Tomato Peel and Seed Extract (TPSE) for its soothing function but also for its capacity to modulate the adrenal axis, involved in stress response. Ex vivo tests were carried out on skin explants to evaluate the effectiveness of TPSE formulated at 0.5% on Calcitonin Gene-Related Peptide (CGRP) and IL-10 release, Kappa Opioid Receptor (KOR) and Caspase 14 expression. An in vivo study combined a clinical evaluation of skin homogeneity, psychological parameter as well as analysis of salivary cortisol and dehydroepiandrosterone concentrations. All measurements were carried out at the beginning and after 28 days of applying a TPSE face cream. TPSE regulated not only the release of CGRP and Il-10, reflecting an anti-neurogenic and anti-inflammatory properties, but also modulated KORs. Twenty height days of TPSE application induced a significant decrease in intensity and extent erythrosis, a lower output of salivary cortisol and a significant increase in pleasant emotions when compared to placebo.
These results provide encouragement to continue exploring the impact of cosmetic ingredient on psychophysiological parameters to improve skin health and well-being.
Evaluation of Proximal Femoral Bone Mineral Density in Cementless Total Hip Arthroplasty
Authors: Hooper Gary , Thompson Deirdre , Frampton Christopher , Lash Nicholas , Sharr Jonathan , Fulker David , Gilchrist Nigel 
Published: December 2023

Background:
Femoral stem design affects periprosthetic bone mineral density (BMD), which may impact long-term survival of cementless implants in total hip arthroplasty (THA). The aim of this study was to examine proximal femoral BMD in 3 morphologically different uncemented femoral stem designs to investigate whether any particular design resulted in better preservation of BMD.

Methods:
A total of 119 patients were randomized to receive a proximally coated collarless dual-taper wedge stem, a proximally coated collarless anatomic stem, or a fully coated collarless triple-taper stem. All surgeries were performed via the posterior approach, with mobilization on the day of surgery. Dual x-ray absorptiometry scans (Lunar iDXA, GE Healthcare) assessed BMD across the 7 Gruen zones preoperatively and at 6 weeks and 2 years postoperatively; if available, the native contralateral femur was also assessed as a control. Patient-reported outcomes of pain, function, and health were also assessed at these follow-ups.

Results:
Averaged across all stems, BMD increased in zones 1 (2.5%), 2 (17.1%), 3 (13.0%), 5 (10%), and 6 (17.9%) at 2 years. Greater preservation of BMD was measured on the lateral cortex (zone 2) for both the dual-taper wedge and anatomic stems (p = 0.019). The dual-taper wedge stem also demonstrated preservation of BMD in the medial calcar (zone 7), while the anatomic and triple-taper stems declined in this region; however, the difference did not reach significance (p = 0.059). Averaged across all stems, BMD decreased in the mid-diaphysis region, distal to the stem tip (zone 4). All stems performed similarly at the time of final follow-up with respect to the patient-reported outcomes.

Conclusions:
This study demonstrated maintenance of femoral BMD after use of 3 different cementless femoral stem designs, with all achieving excellent improvements in patient-reported outcomes. The stems designed to load the proximal metaphyseal region resulted in higher BMD in that region. No significant stress-shielding was observed; however, longer follow-up is required to elucidate the impact of this finding on implant survivorship.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Intermediate to Long-Term Results Following Traumatic Hip Dislocation
Authors: Jaecker Vera , Zocholl Malin , Friederichs Jan , Osten Philipp , Fuchs Thomas , Stuby Fabian M. , Regenbogen Stephan 
Published: December 2023

Background:
Traumatic hip dislocation is a rare yet severe injury. As the long-term morbidity, subsequent complications, and clinical outcomes are nearly unknown, we aimed to analyze traumatic hip dislocations and identify specific factors that may predict the clinical outcome.

Methods:
Data on injury-related characteristics and computed tomographic (CT) scans for all consecutive adult patients who had been managed for traumatic hip dislocation between 2009 and 2021 were analyzed. At the time of follow-up, the patients were assessed with regard to osteonecrosis, posttraumatic osteoarthritis (OA), further operations and complications, return to sports and work, and patient-reported outcome measures (PROMs), including the Tegner Activity Scale and modified Harris hip score.

Results:
One hundred and twelve patients (mean age [and standard deviation], 43.12 ± 16.6 years) were included. Associated acetabular rim and femoral head fractures (Pipkin Type I to IV) were observed in 44% and 40% of patients, respectively. Concomitant injuries occurred in 67% of the patients, most commonly involving the knee (29% of patients). Sixty-nine patients (61.6%) were available for follow-up; the mean duration of follow-up was 6.02 ± 3.76 years. The rates of osteonecrosis and posttraumatic OA were 13% and 31.9%, respectively, and were independent of the timing of hip reduction, leading to subsequent total hip arthroplasty (THA) in 19% of patients. Sciatic nerve injury occurred in 27.5% of the patients who were available for follow-up. Both THA and sciatic nerve injury were associated with posterior acetabular rim or Pipkin Type-IV fractures (p < 0.001). Only 33.3% of the patients returned to their pre-injury level of sports, 24.6% did not return to work, and 27.5% reported having sexual dysfunction. PROMs (Tegner Activity Scale, modified Harris hip score) were significantly worse in patients with osteonecrosis, posttraumatic OA, or residual sciatic nerve injury (p < 0.05).

Conclusions:
Traumatic hip dislocations are predominantly associated with Pipkin and acetabular rim fractures, leading to overall limitations of activities of daily living, sports, and sexual function at intermediate to long-term follow-up. Patients with associated acetabular rim or Pipkin Type-IV fractures are most likely to require THA for the treatment of osteonecrosis or posttraumatic OA and are at greater risk for sustaining sciatic nerve injury.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Deploying the World's Largest Bismuth Alloy Plug for Cost Effective P&A
Authors: Talapatra Didhiti , Carragher Paul John 
Published: December 2023

Abstract
This paper focusses on the successful re-abandonment of a subsea well in the Gulf of Mexico using a rigless approach. The operator had already abandoned the well using conventional technology, but it was still bubbling. The objective was to re-abandon the well by setting a reliable and permanent gas tight seal in the 36" conductor. To achieve this a herculean engineering and operational feat was undertaken to design and manufacture a custom tool using record breaking volume of bismuth and thermite. The tool was deployed from a lift boat and guided into the conductor using ROV's. A timer activation mechanism initiated the thermite heater melting the bismuth alloy cast on to the outside of the tool. The bismuth alloy once molten flowed into the well filling the entire cross section of the 36" conductor. The thermite heater was then retrieved from the molten alloy leaving a solid gas tight metal to metal seal inside the conductor. Observations confirmed the success of the operation, as the bismuth alloy plug created a reliable gas tight seal, with no observed bubbles for a duration of 20 hours. By utilizing bismuth alloy technology, the complexity associated with traditional abandonment methods was eliminated, while ensuring long term reliability. The use of bismuth alloy allowed for a shorter plug length, enabling deployment in the shallow conductor without extensive workover efforts not only reducing costs but also saving time and mitigating HSE risks.
Dissolver Treatments to Re-Instate Functionality of Subsurface Safety Valves in Water Injection Wells
Authors: Hatscher S. T. , Havrevoll N. , Herrmann T. , Gjersdal S. , Dzhuraev D. , Torsvik M. 
Published: December 2023

Abstract
The Downhole Safety Valve (DHSV) integrity tests of two water injection wells on the Nova subsea oil field on the Norwegian Continental Shelf failed after one month in operation. One of the two wells, W-1, also showed issues with the Injection Master Valve (IMV). The objective was to re-instate the functionality of all compromised valves as soon as possible.
First, the root cause for the malfunction was to be identified. Several hypotheses were developed and assessed, including mechanical and chemical issues. Both injectors (W-1 and W-4) are completed in the oil leg of the reservoir and have been cleaned up to rig before an injection test was conducted. The wells were then suspended for several months prior to initial start-up and commencement of water injection. Although wax inhibition was used during the clean-up, wax deposition at DHSV depth could not be fully discarded. Monoethylene glycol (MEG) has been deployed for hydrate mitigation after the injection tests and during initial well start-up. Pressure data indicated that at least partially, a column inversion within the tubing, from water to hydrocarbons, occurred during the suspension period. This observation gave support to that wax or hydrate deposition might restrict the DHSVs' flappers' movement.
Based on this hypothesis, an operation with an Inspection Maintenance and Repair (IMR) vessel was planned, organized and conducted within five weeks after the failed tests. The treatment concept included not only a wax dissolver, but also MEG and heated fluids to combine the benefits of temperature as well as chemical dissolution towards either potential type of deposit. Both wells were treated from the vessel as per plan. The operation successfully re-instated the functionality of all three compromised valves, allowing to safely commence water injection into the reservoir.
Primary Depletion Characterization with No Flow Boundaries Drainage Concept
Authors: Prabowo W. , Rincones M. D. , Boyd D. , Chen C. , Dutta A. 
Published: December 2023

Abstract
In unconventional reservoirs, spacing and stacking directly influence the hydrocarbon resources available to be drained by a given lateral. Hypothetically, these available resources, rock properties and stimulation effectiveness will drive the well performance (i.e., Estimated Ultimate Recovery (EUR)). Characterization of the effectively contacted volume is an important element in understanding the well performance and the depletion efficiency of the intended development.
This paper will present a simple but novel way of characterizing a well's drainage volume and demonstrates how this characterization can be applied to improve the understanding of expected well recovery, primary depletion efficiency (i.e., recovery factor), and their relationship with petrophysics and geology. The methodology is proposed as a method to help lead to optimum development and resource economic value for the operator.
The proposed method uses the concept of no flow boundaries driven by frac geometry established between wells to define a drainage polygon surrounding neighboring laterals. Incorporating supplementary datasets allows further characterization (i.e., well-log to obtain fluid-in-place distribution).
The method provides insights which can be tied back to the well performance. For example, the method shows the importance of geology and petrophysics, reflected through the Original Oil in Place (OOIP) within the drainage volume, driving the well's EUR and recovery factor.
Significance/Novelty: Improved reservoir drainage volume and well performance characterization can significantly impact the optimum development plan, maximizing both the exploitation efficiency and value for operators.
UPF3B modulates endoplasmic reticulum stress through interaction with inositol-requiring enzyme-1α
Authors: Wen Jikai , Sun Xingsheng , Lin Ruqin , Qi Xueying , Lu Xinxia , Wu Zhikai , Jiang Tianqing , Jiang Jun , Mu Peiqiang , Chen Qingmei , Deng Yiqun 
Published: December 2023

Abstract

The unfolded protein response (UPR), as a conserved and adaptive intracellular pathway, relieves the endoplasmic reticulum (ER) stress by activating ER transmembrane stress sensors. As the consequence of ER stress, the inhibition of nonsense mediated mRNA decay (NMD) is due to an increase in the phosphorylation of eIF2α, which has the effect of inhibiting translation. However, the role of NMD in the maintenance of ER homeostasis remains unclear. In this study, we found that the three NMD factors, UPF1, UPF2 or UPF3B, are required to negate UPR. Among these three NMD factors, UPF3B specifically interacts with inositol-requiring enzyme-1α (IRE1α). This interaction inhibited the kinase activity of IRE1α, abolished autophosphorylation and reduced IRE1α clustering for ER stress. BiP and UPF3B jointly control the activation of IRE1α on both sides of the ER membrane. Under stress condition, the phosphorylation of UPF3B was increased and the phosphorylated sites were identified. Both the genetic mutation UPF3BY160D and the phosphorylation at Thr169 of UPF3B abolished its interaction with IRE1α and UPF2, respectively, led the activation of ER stress and NMD disfunction. Our study reveals a key physiological role for UPF3B in the reciprocal regulatory relationship between NMD and ER stress.
A Dark Energy Paradigm: V. Feynman Diagrams with a Hidden Neutrino to Predict Fundamental Boson and Proton Masses
Authors: Moon Yong-Jae , Koh Wook 
Published: December 2023

Abstract
Previously, no theory could explain how the masses of elementary particles are actually set in the Standard Model. In order to solve the problem, a dark energy paradigm a unified dark sector that is based on Planck’s dimensional analysis, ΛCDM , energy conservation, and force equilibrium was first developed by authors to predict lepton6 and quark7 masses successfully. In this paper, we propose that, in the Higgs mechanism, “Feynman diagrams with a hidden neutrino” can be used to predict fundamental boson and proton masses as evidence. We find that the predicted H, Z and W boson masses agree with the observed data with 0.1%, 0.2%, and 0.9% differences. We also find that the predicted proton mass and proton radius agree with the observed data with 0.0006% and 0.03% differences.
A Hybrid-Box tool for Explainable and Interactive Simulated Annealing Strategy
Authors: Ibrahim Osman Ali Sadek , Younis Eman M. G. 
Published: December 2023

Abstract
This concise paper introduces the inaugural Explainable and Interactive Learning to Rank (LTR) Package within the field of Information Retrieval (IR). The framework presented here is built upon the fusion of the Simulated Annealing Strategy with the (1+1)-Evolutionary Strategy, known as SAS-Rank, a ranking algorithm previously established in prior research. In this context, the paper showcases the ranking models associated with both offspring and parent chromosomes during each iterative step. Additionally, it offers three distinct options for modifying the SAS-Rank parameters, allowing for the observation of resulting evaluation outcomes. Notably, this application marks a pioneering endeavor by incorporating interactive learning within the domain of ranking problems in IR.
GZMK+CD8+ T cells Target a Specific Acinar Cell Type in Sjögren’s Disease
Authors: Warner Blake , Pranzatelli Thomas , Perez Paola , Ku Anson , Matuck Bruno Fernandes , Huynh Khoa , Sakai Shunsuke , Abed Mehdi , Jang Shyh-Ing , Yamada Eiko , Dominick Kalie , Ahmed Zara , Oliver Amanda , Wasikowski Rachael , Easter Quinn , Magone M. Teresa , Baer Alan , Pelayo Eileen , Khavandgar Zohreh , Gupta Sarthak , Kleiner David , Lessard Christopher , Farris A , Martin Daniel , Morell Robert , Zheng Changyu , Rachmaninoff Nicholas , Maldonado-Ortiz Jose , Qu Xufeng , Aure Marit , Dezfulian Mohammad , Lake Ross , Teichmann Sarah , Barber Daniel , Tsoi Lam , Sowalsky Adam , Tyc Katarzyna , Gudjonsson Johann , Byrd Kevin , Johnson Philip , Liu Jinze , Chiorini John 
Published: December 2023

Abstract

Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a comprehensive understanding of the cellular landscape of healthy salivary glands and how that landscape changes in SjD patients. We identified novel seromucous acinar cell types and identified a population of PRR4+CST3+WFDC2- seromucous acinar cells that are particularly targeted in SjD. Notably, GZMK+CD8 T cells, enriched in SjD, exhibited a cytotoxic phenotype and were physically associated with immune-engaged epithelial cells in disease. These findings shed light on the immune response's impact on transitioning acinar cells with high levels of secretion and explain the loss of this specific cell population in SjD. This study explores the complex interplay of varied cell types in the salivary glands and their role in the pathology of Sjögren's Disease.
Timing of planned caesarean delivery among patients with two previous cesarean sections
Authors: Haleluya Noa leybovitz , SABAN Alla , YARIV Adi , HERSHKOVITZ Reli 
Published: December 2023

Abstract
Objectives: The timing of planned repeat cesarean delivery (CD) is debateful in clinical practice. Planned repeat CD is typically scheduled before the spontaneous onset of labor in order to minimize the risk of uterine rupture during labor and the associated risk for fetal demise. This timing should be balanced with the potential risk of delivering an infant who could benefit from additional maturation in utero. We aim to study the influence of gestational age at the time of repeat CD on maternal and fetal complications.
Study design: A population-based retrospective cohort study including all term singleton third CDs (>37 weeks of gestation), between February-2020 and January-2022 at a tertiary medical center was conducted. Maternal and neonatal adverse outcomes were compared by gestational age at the time of the CD. A logistic regression models were constructed to adjust for confounders.
Results: The study population included624 third CDs. Among them,two study groups were defined: 199were at 37+0 to 37+6 weeks of gestation, and 44 were at >39 weeks of gestation at the time of delivery. 381 were at 38+0-38+6 weeks. Since our routine practice is to schedule elective CD at 38+0-38+6 weeks of gestation, we defined this group as control group. In a multivariate analysis, both study groups were associated with significantly higher rates of emergent CDs after adjusting for maternal age, parity, ethnicity, premature rapture of membranes, spontaneous onset of labor and birthweight. After adjusting also for emergent CDs, CDs at 37+0-37+6 weeks of gestation was significantly associated with maternal and neonatal length of stay exceeding four days. Additionally, CDs at 37+0-37+6 weeks of gestation was also associated with composite of adverse neonatal and maternal outcomes.
Conclusions:
Our study demonstrated that our institutional policy regarding scheduling third CD at 38+0 to 38+6 weeks is associated with reduced risk of emergent CD, as well as beneficial maternal and neonatal outcomes.