bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixing Rates of the Geometrical Neutral Lorenz Model
Authors: Bruin Henk , Canales Farías Hector Homero 
Published: December 2023

AbstractThe aim of this paper is to obtain polynomial decay of correlations of a Lorenz-like flow where the hyperbolic saddle at the origin is replaced by a neutral saddle. To do that, we take the construction of the geometrical Lorenz flow and proceed by changing the nature of the saddle fixed point at the origin by a neutral fixed point. This modification is accomplished by changing the linearised vector field in a neighbourhood of the origin for a neutral vector field. This change in the nature of the fixed point will produce polynomial tails for the Dulac times, and combined with methods of Araújo and Melbourne (used to prove exponential mixing for the classical Lorenz flow) this will ultimately lead to polynomial upper bounds of the decay of correlations for the modified flow.
Retained EU Law and Implications for Pregnant Workers: A Therapeutic Jurisprudence Perspective
Authors: Kawalek Anna , Rosello Mercedes 
Published: December 2023

AbstractUsing the lenses and language of therapeutic jurisprudence, this paper will argue that the rights of pregnant workers are vulnerable in a post-Brexit climate. Whilst the sunset clause from the Retained EU Law Bill, which would have caused all retained EU law to automatically expire at the end of 2023 unless expressly stated otherwise by Ministers, was lifted, the original drafts of the Bill made clear the government’s lack of respect for and interest in protecting workers’ rights (amongst others). Furthermore, despite the abandonment of the sunset, the now legislated Retained EU Law (Revocation and Reform) Act 2023, aiming to deal with all laws that were once of European origin, still gives Ministers wide powers with limited input from Parliament to change EU derived legislation and replace with UK provision. Using an example from employment law, specifically, pregnant workers, this paper will show that the Act is a therapeutic jurisprudence unfriendly bottle as it has the potential to violate positive physical, social, and psychological outcomes. Recognising that these laws are currently vulnerable, we urge the government to keep intact (and potentially enhance) the laws protecting pregnant workers.
Noncoding RNAs regulating ferroptosis in cardiovascular diseases: novel roles and therapeutic strategies
Authors: Wu Changyong , Bao Suli , Sun Huang , Chen Xiaocui , Yang Lu , Li Ruijie , Peng Yunzhu 
Published: December 2023

AbstractThe morbidity and mortality rates of cardiovascular diseases (CVDs) are increasing; thus, they impose substantial health and economic burdens worldwide, and effective interventions are needed for immediate resolution of this issue. Recent studies have suggested that noncoding RNAs (ncRNAs) play critical roles in the occurrence and development of CVDs and are potential therapeutic targets and novel biomarkers for these diseases. Newly discovered modes of cell death, including necroptosis, pyroptosis, apoptosis, autophagy-dependent cell death and ferroptosis, also play key roles in CVD progression. However, ferroptosis, which differs from the other aforementioned forms of regulated cell death in terms of cell morphology, biochemistry and inhereditability, is a unique iron-dependent mode of nonapoptotic cell death induced by abnormal iron metabolism and excessive accumulation of iron-dependent lipid peroxides and reactive oxygen species (ROS). Increasing evidence has confirmed that ncRNA-mediated ferroptosis is involved in regulating tissue homeostasis and CVD-related pathophysiological conditions, such as cardiac ischemia/reperfusion (I/R) injury, myocardial infarction (MI), atrial fibrillation (AF), cardiomyopathy and heart failure (HF). In this review, we summarize the underlying mechanism of ferroptosis, discuss the pathophysiological effects of ncRNA-mediated ferroptosis in CVDs and provide ideas for effective therapeutic strategies.
Factors mitigating the decline of motivation during the first academic year: a latent change score analysis
Authors: Wild Steffen , Rahn Sebastian , Meyer Thomas 
Published: December 2023

AbstractResearch shows that in university education programs, students’ motivation decreases over time, which is associated with indicators of reduced academic success, such as student dropout rate. Consequently, researchers have analyzed motivation change and explored the options available to universities to maintain a high level of motivation among students. Using Person-environment fit theory, our research suggests that perceived support offered by lecturers and instructional quality influence students’ subject interest. We conducted a longitudinal design of 823 participants from Baden-Wuerttemberg Cooperative State University and estimated a latent change score model using data collected between the participants’ first and second academic years. Our findings suggest that perceived support from lecturers mitigated the decrease in subject interest. Moreover, our results support the hypothesis that universities can attenuate the decreasing change of subject interest from students. Our findings are contextualized with reference to contemporary research in the field and we offer practical suggestions for maintaining high motivation among students.
The genesis of the minimal mind: elements of a phenomenological and functional account
Authors: Marosan Bence Peter 
Published: December 2023

AbstractIn this article, we endeavour to lay the theoretical fundaments of a phenomenologically based project regarding the origins of conscious experience in the natural world. We assume that a phenomenological analysis (based upon Edmund Husserl’s philosophy) of first-person experience could substantially contribute to related empirical research. In this regard, two phenomenological conceptions provided by Husserl are of fundamental importance. The first relates to the essential and necessary embodiment of every subjective experience; the second concerns the intrinsically holistic and concrete character of consciousness. These considerations have two crucial implications. First, every mental content and capability ultimately refers to a bodily basis as its carrier and realizer (‘embodied manifestation thesis’). Second, there is a minimal set of bodily structures that carries and realizes the minimal mind (‘minimal context thesis’). Based upon these assumptions, we can use phenomenology to select from the empirical theories of consciousness. We argue that currently, Bjorn Merker’s subcortical theory of consciousness appears to be the best candidate for a phenomenological approach. In phenomenological regard, however, it is highly challenging to test a subcortical theory; therefore, we suggest that certain experiments based upon emergence from general anaesthesia might help test such a theory in a phenomenologically legitimate way.
Mobility knowledge graph: review and its application in public transport
Authors: Zhang Qi , Ma Zhenliang , Zhang Pengfei , Jenelius Erik 
Published: December 2023

AbstractUnderstanding human mobility in urban areas is crucial for transportation planning, operations, and online control. The availability of large-scale and diverse mobility data (e.g., smart card data, GPS data), provides valuable insights into human mobility patterns. However, organizing and analyzing such data pose significant challenges. Knowledge graph (KG), a graph-based knowledge representation method, has been successfully applied in various domains but has limited applications in urban mobility. This paper aims to address this gap by reviewing existing KG studies, introducing the concept of a mobility knowledge graph (MKG), and proposing a general learning framework to construct MKG from smart card data. The MKG represents hidden travel activities between public transport stations, with stations as nodes and their relations as edges. Two decomposition approaches, rule-based and neural network-based models, are developed to extract MKG relations from smart card data, capturing latent spatiotemporal travel dependencies. The case study is conducted using smart card data from a heavily used urban railway system to validate the effectiveness of MKG in predicting individual trip destinations. The results demonstrate the significance of establishing an MKG database, as it assists in a typical problem of predicting individual trip destinations for public transport systems with only tap-in records. Additionally, the MKG framework offers potential for efficient data management and applications such as individual mobility prediction and personalized travel recommendations.
Frailty-based Lee–Carter family of stochastic mortality models
Authors: Carannante Maria , D’Amato Valeria , Haberman Steven , Menzietti Massimiliano 
Published: December 2023

AbstractIn the actuarial literature, frailty is defined to be the unobserved variable which encompasses all the factors affecting human mortality other than gender and age. Heterogeneity in individual frailty can play a significant role in population mortality dynamics. In the present paper, we identify the main latent factors that explain the frailty component, in order to clarify its role in mortality projections. We show, using longitudinal survey data, that frailty is mainly due to co-morbidities that impact on the process of deterioration in terms of the human body’s physiological capacity. Accordingly, we provide frailty-based stochastic models for projecting mortality based on the Lee–Carter family of models. We propose several versions that consider frailty both as an age-dependent and a time-dependent factor and also combining the interaction effects of age and time in comparison with the general level of mortality, and compare the resulting mortality projections using data from England.
Age-period-cohort analysis of U.S. fertility: a realistic approach
Authors: Billari Francesco , Graziani Rebecca 
Published: December 2023

AbstractA key question for the explanation of fertility trends in advanced societies is whether, in addition to age, period- rather than cohort-related factors matter. In this paper, we analyze a standard set of age-specific fertility rates – from the Human Fertility Database – on the United States between 1933 and 2015. More specifically, we describe and apply an Age-Period-Cohort (APC) modeling approach that relies on second differences as identifiable parameters. Results of our APC analyses tend to be consistent with an interpretation that gives a greater weight to period effects over shorter time horizons, with a significant presence of smooth cohort effects over the longer term.
Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy
Authors: Chacar Stephanie , Abdi Abdulhamid , Almansoori Khalifa , Alshamsi Jawaher , Al Hageh Cynthia , Zalloua Pierre , Khraibi Ali A. , Holt Stephen G. , Nader Moni 
Published: December 2023

AbstractDiabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives maladaptive structural changes and functional damage to the vasculature. Attenuation of this pathological remodeling of blood vessels remains an unmet target owing to paucity of information on the metabolic signatures of this process. Ca2+/calmodulin-dependent kinase II (CaMKII) is expressed in the vasculature and is implicated in the control of blood vessels homeostasis. Recently, CaMKII has attracted a special attention in view of its chronic upregulated activity in diabetic tissues, yet its role in the diabetic vasculature remains under investigation.This review highlights the physiological and pathological actions of CaMKII in the diabetic vasculature, with focus on the control of the dialogue between endothelial (EC) and vascular smooth muscle cells (VSMC). Activation of CaMKII enhances EC and VSMC proliferation and migration, and increases the production of extracellular matrix which leads to maladaptive remodeling of vessels. This is manifested by activation of genes/proteins implicated in the control of the cell cycle, cytoskeleton organization, proliferation, migration, and inflammation. Endothelial dysfunction is paralleled by impaired nitric oxide signaling, which is also influenced by CaMKII signaling (activation/oxidation). The efficiency of CaMKII inhibitors is currently being tested in animal models, with a focus on the genetic pathways involved in the regulation of CaMKII expression (microRNAs and single nucleotide polymorphisms). Interestingly, studies highlight an interaction between the anti-diabetic drugs and CaMKII expression/activity which requires further investigation. Together, the studies reviewed herein may guide pharmacological approaches to improve health-related outcomes in patients with diabetes.
The interaction of a size-dependent tax policy and financial frictions: evidence from a tax reform in Japan
Authors: Hosono Kaoru , Hotei Masaki , Miyakawa Daisuke 
Published: December 2023

Abstract
This study examines the effects of the interaction of a size-dependent tax policy that exempts firms whose stated capital is at or below a certain threshold from taxation and financial frictions on firm growth and financing. Our empirical findings can be summarized as follows: First, firms with lower productivity, a positive potential tax benefit, and smaller stated capital are more likely to conduct the cash-out capital reduction to or below the threshold in response to the policy. Second, this capital reduction causes ex-post lower firm growth and fewer debt. Third, such causal effects are observed for firms with less cash flow ratios. These results indicate that the interaction between a size-dependent tax policy and financial constraints deters firm growth.

Plain English Summary
The interaction of a size-dependent tax policy that exempts firms whose stated capital is at or below a certain threshold from taxation and financial frictions deters firm growth. We use the introduction of the pro forma standard taxation system in Japan that exempts firms (SMEs), whose stated capital is at or below a threshold, from taxation to empirically examine how firms react to this institutional change and how such a reaction systematically affects their financing and real outcomes. We show that size-dependent tax policies can have a significant effect on firms’ growth and financing through financial constraints. It indicates that firms decide whether to obtain an SME status by considering the trade-off between a more severe borrowing constraint and a smaller tax payment. The results obtained in this study indicate that such indirect effects of a size-dependent tax policy on firm dynamics should be considered when designing the policy. Moreover, governments should understand that an institutional change in their tax systems generates a heterogeneous reaction from firms and thus has heterogeneous effects on their dynamics.
The Religious Sign from a Semiotic Perspective a Social-Semiotic Interpretation of the Challenges Presented by the Concept of Religious Sign in the Context of French Schools
Authors: Hauksson-Tresch Nathalie 
Published: December 2023

AbstractThis essay explores the intricate challenges surrounding the concept of religious signs in the context of secular French schools through a social-semiotic lens, drawing inspiration from Michael Halliday's Systemic-Functional Linguistics. It delves into the interplay of language and society, shedding light on three crucial metafunctions: ideational, interpersonal, and textual. The ideational function investigates how religious signs serve as semiotic tools for representing the world and interpreting human experiences. The interpersonal function helps to examine how these signs foster reaction among diverse groups within the school community. Furthermore, the essay scrutinizes the textual function's role in weaving these two functions into coherent discourse, enabling (or not) effective communication. Through an examination of these linguistic components, this essay unravels the complexities of navigating religious signs in French schools, providing insights into the broader socio-cultural dynamics and challenges faced in reconciling diverse religious perspectives with a secular educational system.
Improving Fairness and Equity by Minimizing Community Vulnerability to Food Accessibility: A Computational Urbanism Approach
Authors: Perez-Pereda Maria Jose , Krstikj Aleksandra , Ramirez-Marquez Jose Emmanuel 
Published: December 2023

AbstractOne important point of interest in urban areas is the food outlet, especially retailers that provide fresh and healthy food. Street markets, or tianguis are an affordable option throughout Mexico. Unfortunately, this type of outlet is sometimes inaccessible or significantly far to reach. This paper provides a vulnerability minimization framework to determine the optimal re-allocation of street markets by considering equity and reachability and the exact walking distance and demand by blocks in a city. The framework introduces new concepts of vulnerability along with a novel implementation of the Facility Location Problem. A case study has been used to exemplify the framework based on actual data from a region in Mexico City’s urban zone showing how significant improvements in equity and reachability can be achieved.
Representability of Kleene Posets and Kleene Lattices
Authors: Chajda Ivan , Länger Helmut , Paseka Jan 
Published: December 2023

AbstractA Kleene lattice is a distributive lattice equipped with an antitone involution and satisfying the so-called normality condition. These lattices were introduced by J. A. Kalman. We extended this concept also for posets with an antitone involution. In our recent paper (Chajda, Länger and Paseka, in: Proceeding of 2022 IEEE 52th International Symposium on Multiple-Valued Logic, Springer, 2022), we showed how to construct such Kleene lattices or Kleene posets from a given distributive lattice or poset and a fixed element of this lattice or poset by using the so-called twist product construction, respectively. We extend this construction of Kleene lattices and Kleene posets by considering a fixed subset instead of a fixed element. Moreover, we show that in some cases, this generating poset can be embedded into the resulting Kleene poset. We investigate the question when a Kleene poset can be represented by a Kleene poset obtained by the mentioned construction. We show that a direct product of representable Kleene posets is again representable and hence a direct product of finite chains is representable. This does not hold in general for subdirect products, but we show some examples where it holds. We present large classes of representable and non-representable Kleene posets. Finally, we investigate two kinds of extensions of a distributive poset $${\textbf{A}}$$
A
, namely its Dedekind-MacNeille completion $${{\,\mathrm{\textbf{DM}}\,}}({\textbf{A}})$$

DM

(
A
)

and a completion $$G({\textbf{A}})$$

G
(
A
)

which coincides with $${{\,\mathrm{\textbf{DM}}\,}}({\textbf{A}})$$

DM

(
A
)

provided $${\textbf{A}}$$
A
is finite. In particular we prove that if $${\textbf{A}}$$
A
is a Kleene poset then its extension $$G({\textbf{A}})$$

G
(
A
)

is also a Kleene lattice. If the subset X of principal order ideals of $${\textbf{A}}$$
A
is involution-closed and doubly dense in $$G({\textbf{A}})$$

G
(
A
)

then it generates $$G({\textbf{A}})$$

G
(
A
)

and it is isomorphic to $${\textbf{A}}$$
A
itself.
Early assessment of the pharmacokinetic and pharmacodynamic effects following acetylsalicylic acid loading: toward a definition for acute therapeutic response
Authors: Gurbel Paul A. , Bliden Kevin P. , Kundan Parshotam , Kraft Danielle , Parekh Rueshil , Singh Sahib , Babu Aravind D. , Shah Anika P. , Chaudhary Rahul , Tantry Udaya S. 
Published: December 2023

AbstractDespite decades of investigations, the optimal assessment of the “therapeutic response” to early after loading dose of acetylsalicylic acid (ASA) remains unclear. Limited information is available on the relation between pharmacodynamic (PD) and pharmacokinetic (PK) measurements assessed immediately after ASA administration. Serial PD and PK analyses were performed immediately after a single 162 or 650 mg dose of chewed and swallowed ASA in ten healthy adults. ASA response was defined as > 95% inhibition of serum thromboxane (Tx)B2, < 550 aspirin reaction units (ARU) by VerifyNow Aspirin (VN) test, and ≤ 20% arachidonic acid (AA)-induced platelet aggregation (PA). Correlation analyses between PK and PD measurements and receiver operating characteristic (ROC) curve analyses were performed. ASA response measured by VN test and AA-induced PA was achieved within 30 min of ASA administration. A correlation was observed between ARU and AA-induced maximum PA (r = 0.69, p < 0.001), serum TxB2 (r = 0.74 and p < 0.001), and serum TxB2 inhibition (r = 0.79, p < 0.001). In ROC curve analyses, ≤ 558 ARU and ≤ 7% AA-induced PA were associated with > 95% inhibition of TxB2. 686 ng/ml plasma ASA cut-off point was associated with > 95% inhibition of serum TxB2, ≤ 7% 1 mM AA-induced PA, and ≤ 585 ARU. A modest ~ 50% inhibition of TxB2 inhibition was associated with marked inhibition of 1 mM AA-induced platelet aggregation by LTA. Our analyses demonstrated important relationships between pharmacodynamic, and pharmacokinetic parameters measured immediately following oral ASA and cutoff values for ARU and AA-induced PA that is associated with > 95% inhibition of serum TxB2.
Association between the cardiometabolic index and chronic kidney disease: a cross-sectional study
Authors: Guo Qian , Wang Yani , Liu Yuchen , Wang Yun , Deng Lin , Liao Lihua , Lin Xueqin , Wu Mingxin , Sun Meirui , Liao Ying 
Published: December 2023

Abstract
Background
Central obesity is a risk factor for chronic kidney disease (CKD). However, the exact correlation between the cardiometabolic index (CMI), an indicator of central obesity, and CKD remains unclear. Here, we aimed to investigate the correlation between the CMI and CKD in the general American population.

Methods
This cross-sectional study involved 64,313 members of the general population (≥ 20 years of age) with data in the National Health and Nutrition Examination Survey (NHANES) 1999–2020. The individuals were grouped into three categories by CMI tertile: T1 group (n = 7,029), T2 group (n = 7,356), and T3 group (n = 7,380). Logistic regression analysis was performed, with NHANES recommended weights, to assess the association between the CMI and CKD.

Results
A total of 21,765 participants were included; the overall prevalence of CKD was 12.2%. From the low to the high CMI tertile, the prevalence of CKD increased from 8.9% to 16.0% (P < 0.001). After full adjustment for confounders, the higher tertile of CMI (OR: 1.08, 95% CI: 1.03 − 1.13, P = 0.002) had the higher risk of CKD. Compared with the T1 group, the groups with higher CMI levels had a higher CKD risk (T2: OR: 1.01, 95%CI: 0.87–1.18, P = 0.812; T3: OR: 1.22, 95%CI: 1.05–1.43, P = 0.013).

Conclusions
Higher CMI was independently associated with higher CKD risk in the general population.