bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monolithic 2D Perovskites Enabled Artificial Photonic Synapses for Neuromorphic Vision Sensors
Authors: Wang Yun , Zha Yanfang , Bao Chunxiong , Hu Fengrui , Di Yunsong , Liu Cihui , Xing Fangjian , Xu Xingyuan , Wen Xiaoming , Gan Zhixing , Jia Baohua 
Published: January 2024

AbstractNeuromorphic visual sensors (NVS) based on photonic synapses hold a significant promise to emulate the human visual system. However, current photonic synapses rely on exquisite engineering of the complex heterogeneous interface to realize learning and memory functions, resulting in high fabrication cost, reduced reliability, high energy consumption and uncompact architecture, severely limiting the up‐scaled manufacture, and on‐chip integration. Here a photo‐memory fundamental based on ion‐exciton coupling is innovated to simplify synaptic structure and minimize energy consumption. Due to the intrinsic organic/inorganic interface within the crystal, the photodetector based on monolithic 2D perovskite exhibits a persistent photocurrent lasting about 90 s, enabling versatile synaptic functions. The electrical power consumption per synaptic event is estimated to be≈1.45 × 10−16 J, one order of magnitude lower than that in a natural biological system. Proof‐of‐concept image preprocessing using the neuromorphic vision sensors enabled by photonic synapse demonstrates 4 times enhancement of classification accuracy. Furthermore, getting rid of the artificial neural network, an expectation‐based thresholding model is put forward to mimic the human visual system for facial recognition. This conceptual device unveils a new mechanism to simplify synaptic structure, promising the transformation of the NVS and fostering the emergence of next generation neural networks.
A Boron Scan of Ethyl Acetoacetate Leads to Versatile Building Blocks
Authors: Trofimova Alina , White Brandon , Diaz Diego B. , Širvinskas Martynas J. , Lough Alan , Dudding Travis , Yudin Andrei K. 
Published: January 2024

AbstractDiscovered in the 19th century, ethyl acetoacetate has been central to the development of organic chemistry, including its pedagogy and applications. In this study, we present borylated derivatives of this venerable molecule. A boron handle has been installed at either
‐ or
‐position of acetoacetate by homologation of acyl‐MIDA (N‐methyliminodiacetic acid) boronates with diazoacetates. Either alkyl or boryl groups were found to migrate with regiochemistry being a function of the steric bulk of the diazo species. Boryl
‐ketoesters can be further modified into borylated pyrazolones and oximes, thereby expanding the synthetic toolkit and offering opportunities for additional modifications.
Creating a Just Culture in the Perioperative Setting
Authors: Hooven Katie , Altmiller Gerry 
Published: January 2024

ABSTRACTThere has been an increased perioperative focus on avoiding adverse events and providing safe patient care since To Err Is Human: Building a Safer Health System published in 2000. Adverse events continue to occur in perioperative areas and are likely underreported. The interdisciplinary nature and high cost of perioperative care may discourage personnel from speaking up for fear of retribution and punishment when reporting. Organization leaders can implement a just culture that focuses on improving patient care processes and safety rather than placing blame after an adverse event. A tenet of just culture is achieving balanced accountability between systems and individuals. Strategies for just culture implementation include leader support, policies and procedures for reporting, accessibility of reporting systems, provision of information for staff members, identification of support champions, and creation of a good catch program. Leaders also should measure and track progress associated with the just culture in their facility.
Leveraging Clinical Ladder Nurses to Support an Education Program on Intraoperative Cell Salvage for Obstetric Patients
Authors: Ward Laura 
Published: January 2024

ABSTRACTPostpartum hemorrhage continues to be a leading cause of maternal morbidity and mortality in the United States. With the use of appropriate screening tools and treatment modalities, most of these deaths are preventable. Various interventions are used to prevent and treat postpartum hemorrhage, though intraoperative cell salvage historically has been contraindicated in the obstetric setting. This article explores the implementation of intraoperative cell salvage in the obstetric setting at two campuses of a health care system with the assistance of nurses participating in a professional nurses advancement program (ie, a clinical ladder). The initiative comprised a literature review, interdisciplinary collaboration, and education planning and execution. The educational approach focused on adult learners and included both self‐directed and instructor‐led elements. Including clinical nurses in clinical education is beneficial because they are highly motivated to share evidence‐based practice with their peers to elevate patient safety and quality measures, making them ideal education partners.
Synthesis of mesocarbon microbeads from high‐temperature coal tar pitch: Effects of quinoline insoluble
Authors: Zishuo Gu , Fei Wang , Yunyang Wang , Yilin Fang , Yaming Zhu , Jun Lv , Junxia Cheng , Ying Wang , Xuefei Zhao 
Published: January 2024

AbstractMesocarbon microbeads (MCMBs) were a kind of functional artificial carbon materials, which was widely used in varied areas with its excellent properties. MCMB was generally produced by thermal‐polymerization of high‐temperature coal tar pitch under oxygen‐free atmosphere. Generally, the content of primary quinoline insoluble (PQI) play a key role on the quality of the derived MCMB. In order to confirm the relationship between the content of PQI and the properties of MCMB, 15 kinds of high‐temperature coal tar pitch with varied content of PQI were used as the raw materials to produce MCMB. The particle size distribution, optical micro‐structure, surface morphology, and carbon micro‐crystalline of calcinated MCMB were determined in this work. The results shown that the content of PQI from 7% to 13% was a suitable content to generate high quality MCMB. What is more, the derived MCMB has a high yield of 33.09% with good sphericity, the uniformity index of particle size was 1.02, and the graphite carbon content of calcinated MCMB (calcinated temperature of 1100°C) was 79.92%. Thus, the high‐temperature coal tar pitch with the PQI content of 7%–13% was the preferably raw materials to produce high‐quality MCMB by thermal‐polymerization method.
Effect of hygrothermal conditioning on compressive strength after impact in carbon fiber/epoxy composites
Authors: de Paiva Jane Maria Faulstich , Hosokawa Meire Noriko , Montagna Larissa Stieven , Rezende Mirabel Cerqueira 
Published: January 2024

AbstractCarbon fiber‐reinforced polymers have been widely applied in structural parts and components in several sectors, in addition to being constantly used in environments with the presence of humidity and high temperatures, which can affect their density, hardness, and rigidity. In this work, the influence of hydrothermal conditioning on carbon fiber (CF)/epoxy composites was investigated using three types of epoxy resin and two different CF fabric reinforcements, that is, plain weave and eight harness satin (8HS) arrangements. The CF/epoxy composites were subjected to compression after impact (CAI) test by 28 and 40 J energy and then exposed to hydrothermal conditioning for 8 weeks. After the CAI tests, the visual analysis of all composites presented microbuckling mechanisms. The composites tested with 40 J energy absorbed only 2% more moisture compared with the other composites, nonimpacted, and tested with 28 J, indicating that the impact damage did not cause delamination between the layers of the composites, which could facilitate the absorption of water. All composites analyzed showed resistance to CAI even after exposure to humidity, with decreases ranging from 2.8% to 23.8% about the unconditioned specimens. The decrease in CAI also shows the influence of the type of epoxy matrix and the arrangement of the CF in fabrics.
Effect of Recent Antirheumatic Drug on Features of Rheumatoid Arthritis–Associated Lymphoproliferative Disorders
Authors: Hoshida Yoshihiko , Tsujii Atsuko , Ohshima Shiro , Saeki Yukihiko , Yagita Masato , Miyamura Tomoya , Katayama Masao , Kawasaki Tomonori , Hiramatsu Yasushi , Oshima Hisaji , Murayama Toshihiko , Higa Shinji , Kuraoka Kazuya , Hirano Fuminori , Ichikawa Kenji , Kurosawa Mitsutoshi , Suzuki Hiroaki , Chiba Noriyuki , Sugiyama Takao , Minami Yuko , Niino Hitoshi , Ihata Atsushi , Saito Ikuo , Mitsuo Akiko , Maejima Toshitaka , Kawashima Atsuhiro , Tsutani Hiroshi , Takahi Koichiro , Kasai Takahiko , Shinno Yoko , Tachiyama Yoshiro , Teramoto Norihiro , Taguchi Kenichi , Naito Shinji , Yoshizawa Shigeru , Ito Masahiro , Suenaga Yasuo , Mori Shunsuke , Nagakura Shoichi , Yoshikawa Norie , Nomoto Mitsuharu , Ueda Atsuhisa , Nagaoka Shouhei , Tsuura Yukio , Setoguchi Keigo , Sugii Shoji , Abe Asami , Sugaya Toshiaki , Sugahara Hiroyuki , Fujita Shigeki , Kunugiza Yasuo , Iizuka Norishige , Yoshihara Ryosuke , Yabe Hiroki , Fujisaki Tomoaki , Morii Eiichi , Takeshita Morishige , Sato Masakazu , Saito Kazuyoshi , Matsui Kiyoshi , Tomita Yasuhiko , Furukawa Hiroshi , Tohma Shigeto 
Published: January 2024

ObjectiveIn this study, we examine how advancements in novel antirheumatic drugs affect the clinicopathologic features of lymphoproliferative disorder (LPD) in patients with rheumatoid arthritis (RA).MethodsIn this multicenter study across 53 hospitals in Japan, we characterized patients with RA who developed LPDs and visited the hospitals between January 1999 and March 2021. The statistical tools used included Fisher's exact test, the Mann‐Whitney U‐test, the log‐rank test, logistic regression analysis, and Cox proportional hazards models.ResultsOverall, 752 patients with RA‐associated LPD (RA‐LPD) and 770 with sporadic LPD were included in the study. We observed significant differences in the clinicopathologic features between patients with RA‐LPD and those with sporadic LPD. Histopathological analysis revealed a high frequency of LPD‐associated immunosuppressive conditions. Furthermore, patients with RA‐LPD were evaluated based on the antirheumatic drugs administered. The methotrexate (MTX) plus tacrolimus and MTX plus tumor necrosis factor inhibitor (TNFi) groups had different affected site frequencies and histologic subtypes than the MTX‐only group. Moreover, MTX and TNFi may synergistically affect susceptibility to Epstein‐Barr virus infection. In case of antirheumatic drugs administered after LPD onset, tocilizumab (TCZ)–only therapy was associated with lower frequency of regrowth after spontaneous regression than other regimens.ConclusionAntirheumatic drugs administered before LPD onset may influence the clinicopathologic features of RA‐LPD, with patterns changing over time. Furthermore, TCZ‐only regimens are recommended after LPD onset.image
Diglyme as a Promoter for the Electrochemical Formation of Quaternary Graphite Intercalation Compounds Containing two Different Types of Solvents
Authors: Son Youhyun , Åvall Gustav , Ferrero Guillermo A. , Freytag Annica I. , Escher Ines , Janßen Knut Arne , Jauregui Maria , Saurel Damien , Galceran Montserrat , Adelhelm Philipp 
Published: January 2024

AbstractCo‐intercalation using ether‐based electrolytes renders graphite as a promising anode material in sodium‐ion batteries (SIBs). While most research on electrochemical solvent co‐intercalation in graphite has focused on linear ethers such as mono‐, di‐, tri‐, tetra‐, and penta‐glyme, we herein investigate the possibility of reversible electrochemical co‐intercalation with alternative solvents, especially cyclic ethers tetrahydrofuran (THF) and 1,3‐dioxolane (DOL), which show no signs of co‐intercalation on their own. We demonstrate, however, that this reaction becomes feasible when incorporating diethylene glycol dimethyl ether (2G, diglyme) as an additive. Operando X‐ray diffraction and ex‐situ ss‐NMR techniques are employed comprehensively to understand the co‐intercalation reaction of these cyclic ethers, along with Na+‐glymes, into graphite during cycling. When using these mixed electrolytes i. e., THF/2G and DOL/2G, the voltage profiles changes compared to the pure glyme‐based electrolyte, while showing comparable specific capacities and good long‐term durability. Overall, we propose that even trace amounts of diglyme prompt the co‐intercalation of THF and DOL into graphite layers. This leads to the formation of quaternary graphite intercalation compounds (q‐GICs), expanding beyond the realm of ternary graphite intercalation compounds (t‐GICs).
A deep‐red xanthene‐based highly sensitive fluorescent probe for detection of hypochlorite
Authors: Sun Jie , Abdulahat Mehrigul , Obolda Ablikim , Ma Xuelian , Hazretomar Parida , Ding Zhaoze , Wang Jinquan 
Published: January 2024

AbstractAs an oxidant, deodorant and bleaching agent, the hypochlorous acid (HClO) and hypochlorite (ClO−) are widely used in corrosion inhibitors, textile dyes, pharmaceutical intermediates and in our daily lives. However, excess usage or aberrant accumulation of ClO− leads to tissue damage or some diseases and even cancer. Therefore, it is necessary to develop a fluorescent probe that specifically identifies ClO−. In this article, we synthesized a deep‐red xanthene‐based fluorescent probe (XA‐CN). The strong electron deficient group dicyano endows the probe XA‐CN deep‐red fluorescent emission with high solubility, selectivity and sensitivity for ClO− detection. Studies showed that the probe demonstrated turn‐off fluorescence (643 nm) at the presence of ClO− in dimethylsulfoxide/phosphate‐buffered saline 1:1 (pH 9) solution with a limit of detection of 1.64 μM. Detection mechanism investigation revealed that the electron deficient group ‐CN and the hydroxyl group was oxidized into aldehyde or carbonyl groups at the presence of ClO−, resulting ultraviolet‐visible absorption of the probe blue shifted and turned‐off fluorescence. Furthermore, XA‐CN was successfully used for the detection of ClO− in tap water samples.
LGBTQ+ inequity in crowdfunding cancer costs: The influence of online reach and LGBTQ+ state policy
Authors: Waters Austin R. , Easterly Caleb W. , Turner Cindy , Ghazal Lauren , Tovar Ida , Mulvaney Megan , Poquadeck Matt , Rains Stephen A. , Cloyes Kristin G. , Kirchhoff Anne C. , Kent Erin E. , Warner Echo L. 
Published: January 2024

AbstractBackgroundEmerging literature suggests that LGBTQ+ cancer survivors are more likely to experience financial burden than non‐LGBTQ+ survivors. However, LGBTQ+ cancer survivors experience with cost‐coping behaviors such as crowdfunding is understudied.MethodsWe aimed to assess LGBTQ+ inequity in cancer crowdfunding by combining community‐engaged and technology‐based methods. Crowdfunding campaigns were web‐scraped from GoFundMe and classified as cancer‐related and LGBTQ+ or non‐LGBTQ+ using term dictionaries. Bivariate analyses and generalized linear models were used to assess differential effects in total goal amount raised by LGBTQ+ status. Stratified models were run by online reach and LGBTQ+ inclusivity of state policy.ResultsA total of N = 188,342 active cancer‐related crowdfunding campaigns were web‐scraped from GoFundMe in November 2022, of which N = 535 were LGBTQ+ and ranged from 2014 to 2022. In multivariable models of recent campaigns (2019–2022), LGBTQ+ campaigns raised $1608 (95% CI: −2139, −1077) less than non‐LGBTQ+ campaigns. LGBTQ+ campaigns with low (26–45 donors), moderate (46–87 donors), and high (88–240 donors) online reach raised on average $1152 (95% CI: −$1589, −$716), $1050 (95% CI: −$1737, −$364), and $2655 (95% CI: −$4312, −$998) less than non‐LGBTQ+ campaigns respectively. When stratified by LGBTQ+ inclusivity of state level policy states with anti‐LGBTQ+ policy/lacking equitable policy raised on average $1910 (95% CI: −2640, −1182) less than non‐LGBTQ+ campaigns from the same states.Conclusions and RelevanceOur findings revealed LGBTQ+ inequity in cancer‐related crowdfunding, suggesting that LGBTQ+ cancer survivors may be less able to address financial burden via crowdfunding in comparison to non‐LGBTQ+ cancer survivors—potentially widening existing economic inequities.
Design of Functional Globular β‐Sheet Miniproteins
Authors: Pham Truc Lam , Thomas Franziska 
Published: January 2024

AbstractThe design of discrete β‐sheet peptides is far less advanced than e. g. the design of α‐helical peptides. The reputation of β‐sheet peptides as being poorly soluble and aggregation‐prone often hinders active design efforts. Here, we show that this reputation is unfounded. We demonstrate this by looking at the β‐hairpin and WW domain. Their structure and folding have been extensively studied and they have long served as model systems to investigate protein folding and folding kinetics. The resulting fundamental understanding has led to the development of hyperstable β‐sheet scaffolds that fold at temperatures of 100 °C or high concentrations of denaturants. These have been used to design functional miniproteins with protein or nucleic acid binding properties, in some cases with such success that medical applications are conceivable. The β‐sheet scaffolds are not always completely rigid, but can be specifically designed to respond to changes in pH, redox potential or presence of metal ions. Some engineered β‐sheet peptides also exhibit catalytic properties, although not comparable to those of natural proteins. Previous reviews have focused on the design of stably folded and non‐aggregating β‐sheet sequences. In our review, we now also address design strategies to obtain functional miniproteins from β‐sheet folding motifs.
Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population
Authors: Sharma Sachin , Ghufran Shaikh Maryam , Aftab Mehreen , Bihari Chhagan , Ghose Sampa , Biswas Subhrajit 
Published: January 2024

AbstractPersistent activation of hepatic stellate cells (HSCs) in the injured liver leads to the progression of liver injury from fibrosis to detrimental cirrhosis. In a previous study, we have shown that survivin protein is upregulated during the early activation of HSCs, which triggers the onset of liver fibrosis. However, the therapeutic potential of targeting survivin in a fully established fibrotic liver needs to be investigated. In this study, we chemically induced hepatic fibrosis in mice using carbon tetrachloride (CCl4) for 6 weeks, which was followed by treatment with a survivin suppressant (YM155). We also evaluated survivin expression in fibrotic human liver tissues, primary HSCs, and HSC cell line by histological analysis. αSMA+ HSCs in human and mice fibrotic liver tissues showed enhanced survivin expression, whereas the hepatocytes and quiescent (qHSCs) displayed minimal expression. Alternatively, activated M2 macrophage subtype induced survivin expression in HSCs through the TGF‐β‐TGF‐β receptor‐I/II signaling. Inhibition of survivin in HSCs promoted cell cycle arrest and senescence, which eventually suppressed their activation. In vivo, YM155 treatment increased the expression of cell senescence makers in HSCs around fibrotic septa such as p53, p21, and β‐galactosidase. YM155 treatment in vivo also reduced the hepatic macrophage population and inflammatory cytokine expression in the liver. In conclusion, downregulation of survivin in the fibrotic liver decreases HSC activation by inducing cellular senescence and modulating macrophage cytokine expression that collectively ameliorates liver fibrosis.
Probing the Isolobal Relation between Cp′′′NiP3 and White Phosphorus by Experimental Charge Density Analysis
Authors: Meurer Florian , Kleemiss Florian , Riesinger Christoph , Balázs Gábor , Vuković Vedran , Shenderovich Ilya G. , Jelsch Christian , Bodensteiner Michael 
Published: January 2024

AbstractAn in‐depth analysis of the description of bonding within Cp′′′Ni‐cyclo‐P3 (Cp′′′=1,2,4‐tri‐tert‐butylcyclopentadienyl, [Ni]P3) employing X‐ray diffraction based multipolar modeling, density functional theory (DFT) as well as an “experimental wavefunction” obtained from X‐ray restrained wavefunction (XRW) fitting is presented. The results are compared to DFT calculations on white phosphorus – an isolobal analogue to [Ni]P3. A complementary bonding analysis shows insights into the reactivity of [Ni]P3. The isolobal principle is reflected in every aspect of our analysis and the employed methods seamlessly predict the differences in reactivity of [Ni]P3 and P4. Crystallographic modeling, solid‐state NMR, and DFT calculations describe the dynamic behavior of the cyclo‐P3 unit in the title molecule.
Reversible Restrain and Release of the Dynamic Valence Isomerization in a Shape‐shifting Bullvalene by Complex Formation
Authors: Dohmen Christoph , Paululat Thomas , Ihmels Heiko 
Published: January 2024

AbstractIn search for structural features that enable the control of the valence isomerization of the fluxional bullvalene, a bullvalene‐bis(harmane) conjugate is identified that acts as chelating ligand in complexes with metal ions. Spectrometric titrations show that this ligand forms 1 : 1 complexes with Ag+, Cu+, Cu2+, and Zn2+. Most importantly, detailed NMR‐spectroscopic analysis at different temperatures reveals that the complexation with Ag+ strongly affects the dynamic isomerization of the bullvalene unit of the ligand such that only one predominant valence isomer is formed, even at 5 °C. Detailed 1H‐NMR‐spectroscopic studies disclose an increased barrier (~11 kJ mol−1) of the Cope rearrangement. Furthermore, the addition of hexacyclene displaces the Ag+ from the complex, so that the valence isomerization is accelerated and an equilibrium with two predominant isomers is formed. In turn, repeated addition of Ag+ regains the complex with the restrained isomerization of the bullvalene unit. This method to control the valence isomerism by straightforward chemical stimuli may be used to simplify structural analysis at elevated temperatures, i. e. a feature not available so far with bullvalenes, and it may be employed as functional element in dynamic supramolecular assemblies.
Synthesis and Biological Evaluations of Novel Human Parathyroid Hormone 1 Receptor (hPTHR1) Agonists Bearing Bicyclic Aromatic Moiety
Authors: Nishimura Yoshikazu , Esaki Toru , Isshiki Yoshiaki , Furuta Yoshiyuki , Emura Takashi , Watanabe Yoshiaki , Ohta Masateru , Arai Shinichi , Noda Hiroshi , Shimizu Masaru , Tamura Tatsuya , Sato Haruhiko 
Published: January 2024

AbstractWe have previously shown that the small molecule hPTHR1 agonist PCO371 (1) orally and dose‐dependently induces PTH‐like calcemic and hypophostemic activity in thyroparathyroidectomized rats. Compound 2a, bearing a bicyclic aromatic ring, was identified as a novel hPTHR1 agonist during hit to lead modification. It showed moderate PTHR1 agonistic activity with an EC20 value of 15 μM, and its metabolic stability in human liver microsome (hLM) as well as its solubility in phosphate buffer (PPb) and Fasted state simulated intestinal fluid (FaSSIF) were found to be poor. As results of the initial derivatization of 2a, we identified the indole derivatives as another scaffold. In this article, we report on the structure‐activity relationship (SAR), structure‐metabolism relationship (SMR), and structure‐solubility relationship (SSR) of bicyclic aromatic derivatives, and the in vivo efficacy of 2j.