bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicenter Population Pharmacokinetics of Fentanyl in Neonatal Surgical Patients Using Dried Blood Spot Specimen Collection Demonstrates Maturation of Elimination Clearance
Authors: Rzasa Lynn Rachael S. , Henthorn Thomas K. , Zuk Jeannie , Hammer Gregory B. , Drover David R. , Levy Richard J. , Maxwell Lynne G. , Sadhasivam Senthilkumar , Suresh Santhanam , Galinkin Jeffrey L. 
Published: January 2024

BACKGROUND:
Fentanyl is widely used for analgesia and sedation in neonates, but pharmacokinetic (PK) analysis in this population has been limited by the relatively large sample volumes required for plasma-based assays.

METHODS:
In this multicenter observational study of fentanyl kinetics in neonates up to 42 weeks of postmenstrual age (PMA) who received fentanyl boluses and continuous infusions, dried blood spots were used for small-volume sampling. A population PK analysis was used to describe fentanyl disposition in term and preterm neonates. Covariates for the model parameters, including body weight, PMA, birth status (preterm or term), and presence of congenital cardiac disease, were assessed in a stepwise manner.

RESULTS:
Clearance was estimated to be greater than adult clearance of fentanyl and varied with weight. Covariate selection did not yield a significant relationship for age as a continuous or dichotomous variable (term or preterm, the latter defined as birth with PMA of <37 weeks) and clearance.

CONCLUSIONS:
A supra-allometric effect on clearance was determined during covariate analyses (exponential scaling factor for body weight >0.75), as has been described in population PK models that account for maturation of intrinsic clearance (here, predominantly hepatic microsomal activity) in addition to scaling for weight, both of which impact clearance in this age group.
Missing Poetry: A historiography of Albanian Literature during the Communist Regime
Authors: Macaj Edlira 
Published: January 2024

The paper aims at a panoramic view of the partial representation of Albanian poetry in the texts of the history of Albanian literature published during the dictatorship period (1945–1990). The fragmentary presentation of Albanian poetry and poets in informative scholarly and university texts on literature highlights the complications and the problems derived from this one-sided representation. The information gained only after the fall of the dictatorship, changed the situation regarding the literary values specifically related to poetry. What crucial representative texts on Albanian literary history were published during the dictatorship? Who were the most noticeable authors and poets, and why were they set aside, censored, imprisoned, executed, and not published? The answers suggest that only thanks to political change and awareness of literature can the reader today reassess this missing part of Albanian literature in historical texts published during the communist regime.
The methodology relies on a historical, analytical, and critical approach to the most representative authors and their texts that is intertwined with factual data. The conclusions reinforce the idea that any evaluation of the literary process dictated by extra-literary principles damages the natural literary process. The revitalisation of literature after the 1990s, although with much delay, restored the natural process of aesthetic assessment. Now we can reassess the best part of that missing poetry.
Pembuatan Animasi Game Pemasangan NGT sebagai Media Pembelajaran Praktikum KDM
Authors: Siscadarsih Indraswari , Ramadhani Devy Kurnia , Dewi Nur Indah Kusuma 
Published: January 2024

The competence of a midwife has a major influence on the quality of midwifery services provided. The Midwifery education program structure contains 40% theory and 60% practice. Background: During the COVID-19 pandemic, there has been a rapid and drastic change in health education. With the restrictions during the pandemic, student access to the laboratory is also hampered. Objective: This research allows the creation of new learning media based on game animation that can provide students with a real audio-visual picture of a particular midwifery care procedure. Methods: The design of this research is Research and Development (Research and Development). The development research model used is ADDIE with the stages of Analysis, Design, Development and, Production, Implementation, Evaluation. The data collection method used in this study was means of observation and questionnaires. Tests in this study were conducted to test the usability aspect. Results: This application can be used on Windows-based personal computers and Android-based mobile phones. The results of testing the usability quality of the NGT installation game application are 91.56% and get a very good predicate so that this application can be used for practical learning. Conclusion: The NGT installation game application can be used as a KDM practicum learning media.
Miskoncepce z pedologie u studentů učitelství přírodních věd
Authors: Chmelová Štěpánka 
Published: January 2024

Tato studie se zabývá analýzou miskoncepcí z pedologie u budoucích učitelů přírodopisu, kteří studují na Pedagogické fakultě Jihočeské univerzity v Českých Budějovicích. Nejčastější miskoncepce byly zjišťovány pomocí 10 testových úloh s otevřenou odpovědí. Soubor respondentů tvořilo celkem 35 studentů bakalářského studia. V rámci této studie byly zjištěny četné miskoncepce u budoucích pedagogů. Nejčastěji zjištěné miskoncepce byly tyto: půda není „živá“, půdní druh a půdní typ je jedno a to samé, půda se řadí mezi obnovitelný zdroj, rostliny si z půdy berou vše pro svůj růst a vývoj, humus jsou jen rozložené rostliny. Až 37 % respondentů se potýká s jedním nebo dokonce s více miskoncepty z učiva pedologie. Půda, její vznik, význam a vlastnosti jsou důležité pro pochopení souvislostí mezi živou a neživou přírodou a patří mezi jedno z nejdůležitějších integrovaných přírodovědných témat. V didaktickém výzkumu je proto potřeba se zaměřit na moderní výukové strategie a snažit se odstranit tyto miskoncepce ve výuce o půdě.
Weakly Kähler hyperbolic manifolds and the Green–Griffiths–Lang conjecture
Authors: Bei Francesco , Diverio Simone , Eyssidieux Philippe , Trapani Stefano 
Published: January 2024

Abstract
We introduce the notion of weakly Kähler hyperbolic manifold which generalizes that of Kähler hyperbolic manifold given in the early 1990s by M. Gromov, and establish its basic features. We then investigate its spectral properties and show a spectral gap result (on a suitable modification).
As applications, we prove that weakly Kähler hyperbolic manifolds are of general type and we study the geometry of their subvarieties and entire curves, verifying – among other things – various aspects of the Lang and the Green–Griffiths conjectures for this class of manifolds.
Self-presentation as an ELF user in social media: an analysis of Japanese young adults’ online language practices
Authors: Tanaka Aina 
Published: January 2024

Abstract
This paper delves into the identity constructions of Japanese young adults as users of English as a lingua franca on social media, with a specific focus on Instagram, a widely utilized platform among this demographic. Grounded in the premise that social media serves as a space for self-presentation, drawing from the social constructivist idea that the self is a performative act, the study centers on three Japanese young individuals with overseas experiences. It explores how they employ English as a communicative lingua franca in a transnational space while remaining highly conscious of their Japanese followers, endeavoring to portray idealized English-speaking selves. An ethnographic approach (Netnography) to the participants’ online practices involves prolonged online observations and interviews, seeking not only screen-based linguistic data but also uncovering the speakers’ voices behind the online screen. The findings illuminate that their identities as experienced English users evolves into a distinct aspiration to present themselves as competent English users. This aspiration is intricately attached to English ideologies, including native speakerism and the social status of English. The study provides valuable insights into the importance of scrutinizing the complex identity construction and language negotiation among speakers in ELF contexts, particularly within the realm of everyday online discourse. It sheds light on how young online users navigate between identities as English users and learners in the dynamic context of both global and local friendships.
Effects of co-inoculation of indole-3-acetic acid- and ammonia-producing bacteria on plant growth and nutrition, soil elements, and the relationships of soil microbiomes with soil physicochemical parameters
Authors: Pongsilp Neelawan , Nimnoi Pongrawee 
Published: January 2024

Abstract
To cope with the problem of the reduction in agricultural productivity, the massive usage of chemical fertilizers for boosting agricultural productivity is popular across the world. In return, it thereby declines soil quality and biodiversity. We therefore determined the potential of co-inoculation of the indole-3-acetic-acid- and ammonia-producing bacteria, Pseudomonas sp. strain NK2/7 and Bacillus sp. strain NK1/19, immobilized in agar to promote mustard greens growth and investigated the effects of co-inoculation of both strains on plant and soil elements as well as soil bacterial community structure, in comparison with a chemical fertilizer and single-strain inoculations. The knowledge on the relationships of both species with plant and soil microbiota in field conditions is limited. The results show that the co-inoculation of both strains immobilized in agar increased plant dry weight up to 62.02% and plant elements, including N (38.46%), P (28.37%), K (203.16%), Ca (10.89%), Mg (25.8%), and Na (70.3%). The co-inoculation also conferred the highest organic matter (OM) (by 429.45%) and increased soil elements including Fe (92.74%), Mn (126.88%), Cu (12.05%), and Zn (107.46%). Illumina next-generation sequencing demonstrated that the establishment of both strains affected the soil bacterial community by reducing bacterial diversity and richness. Bacterial classes Bacteroidia, alpha-Proteobacteria, Vicinamibacteria, Gemmatimonadetes, Verrucomicrobiae, Polyangia, Nitrososphaeria, and Blastocatellia were significantly decreased, whereas the amounts of gamma-Proteobacteria and Bacilli were significantly increased. Soil parameters, including pH, OM, total Fe, Mn, Cu, and Zn, were the major factors influencing the soil bacterial community structure.
Fault diagnosis using signal processing and deep learning-based image pattern recognition
Authors: Ren Zhenxing , Guo Jianfeng 
Published: January 2024

Abstract
The vibration signal is a typical non-stationary signal, making it challenging to use traditional time-frequency analysis techniques for fault diagnosis. Therefore, this work investigates the processing of vibration signals and proposes a deep learning method based on processed signals for the fault diagnosis of ball bearings. In this work, the fault diagnosis is formulated as an image classification problem and solved with deep learning networks. The intrinsic mode functions (IMFs), converted from the vibration signals in the time domain, are then transformed into symmetrized dot pattern (SDP) images. In order to increase classification accuracy, the SDP parameters in this study are chosen by optimizing image similarity. The feasibility and accuracy of the proposed approach are examined experimentally.
Metalinguistic discourses of ‘styling the other’
Authors: Makoni Busi 
Published: January 2024

This article explores how mobility shapes language, gender and sexuality during periods of indeterminacy, focusing on the discursive construction of masculinities. Using styling/‘styling the other’ as an interpretive framework, the article analyses how economic precarity leads to ambivalence in the masculinities of Zimbabwean heterosexual-identifying male migrants (ages 26–30 years) in Johannesburg. Interview data suggests that these men engaged in male-to-male sex work to achieve economic security. To solicit wealthy white men, the men performed stereotypical Black hypermasculinity and sophisticated, cosmopolitan gay subjectivities through language crossing and physical styling. These performances ultimately aimed to achieve the normative masculine identity of being a husband and provider. The article elucidates the paradox in which the men appropriated Polari, a British gay patois, and foreign or white understandings of Black/African masculinity to style the ‘other’ while fulfilling traditional Zimbabwean notions of masculinity.
Implications from an Ongoing Scabies Outbreak During the COVID-19 Isolation Period: Clues for Controlling Scabies Today
Authors: GÜLBAŞARAN Fatmagül , GÜNDÜZ Kamer 
Published: January 2024

Background: Contrary to the expectation that the number of scabies cases will decrease during the COVID-19 isolation period, scabies has been frequently reported in Turkey.
Objective: The aim of this study is to investigate the epidemiological pattern of the scabies outbreak in the context of the pandemic to provide additional information for the control of the devastating scabies outbreak that continues today.
Methods: Patients seen in our dermatology clinic before and during the pandemic were evaluated retrospectively.
Results: There was no decrease in the rate of scabies patients among all dermatology admissions during the pandemic period (n=143/2912; 4.9%) compared to the pre-pandemic period (n=526/11679; 4.5%) (p=0.348). The high incidence of the new scabies cases before the detection of COVID-19 in the country decreased in the quarantine period. However, the high recurrent admissions of old scabies cases, who already got scabies before pandemic but could not be cured despite repeated treatments, contributed to the ongoing high prevalance of scabies during the pandemic (one-third of all scabies cases seen during the pandemic, n=30/87).
Conclusions: We suggest that self-quarantine and increased hygiene during COVID-19 reduced re-infestations and led to a decrease in new cases. Treatment failure of old cases has been observed to contribute to the high prevalence of scabies in the pandemic. Permethrin resistance may have led to inadequate treatment success, given that treatment application errors, which may also lead to treatment failure, are managed with active surveillance in our patient population. Studies addressing permethrin resistance are needed as a priority.
Theoretical and Experimental Study on Parameter Optimization of Active Sources in Seismic Tomography
Authors: Tian Xinyuan , Gong Siyuan , Dou Linming , Hu Shun , Chen Bengang , Lu Qiang 
Published: January 2024

Abstract
Given the high cost of active seismic tomography and the large influence on mining production, as well as the uncontrollable inversion period and accuracy of the target area during the passive seismic tomography, an optimization algorithm based on adding a certain number of artificial microseism (active sources) was proposed through the distribution characteristic of microseismic events (passive sources). The active source parameter optimization method realizes the combination of active source and passive source and improves the accuracy of inversion at the same time. The method uses a multiobjective optimization genetic algorithm to fuse the accuracy index and stability index that preevaluates the inversion effect and solves the best combination of active sources to improve the inversion effect. At the same time, experimental studies were carried out. After the active source was added, the inversion accuracy of high-stress areas and the ability to resist data errors were greatly improved. The inversion results were more in line with the law of stress transfer and stress distribution, which enhanced the connectivity of the low-velocity area of the fault zone or weakened zone.
Carbon Isotopic Behavior During Hydrocarbon Expulsion in Semiclosed Hydrous Pyrolysis of Type I and Type II Saline Lacustrine Source Rocks in the Jianghan Basin, Central China
Authors: Li Shaojie , Zheng Lunju , Guo Xiaowen , Han Yuanjia 
Published: January 2024

Abstract
Organic carbon isotopic analysis is a significant approach for oil-source correlation, yet organic carbon isotopic behavior during oil expulsion from saline lacustrine source rocks is not well constrained, and this hinders its wide application for fingerprinting oils generated by saline lacustrine source rock. To resolve this puzzle, semiclosed hydrous pyrolysis was conducted on typical saline lacustrine source rocks from the Qianjiang Formation (type I kerogen) and Xingouzui Formation (type II kerogen) sampled in the Jianghan Basin, China, under high-temperature high-pressure conditions (T = 275℃–400℃; P = 65–125 MPa). Experimental results show that there is minor carbon isotopic fractionation (&lt;3‰) between pyrolyzed and nonpyrolyzed retained oil fractions during the main oil generation/expulsion stage of both type I and II source rocks. Carbon isotopic fractionations between expelled and retained oil fractions are also minor (&lt;2‰) during this stage. The δ13C values of retained and expelled oil fractions generated by the type I saline lacustrine source rock correlate positively with the degree of oil expulsion, whereas the influence of oil expulsion on the δ13C values of oil fractions generated by the type II source rock was not consistent. In addition, carbon isotopic analysis also unravels the mixing of oil-associated gases with different maturity levels and/or generated via different processes. Outcomes of this study demonstrate that oil expulsion from type I and II saline lacustrine source rocks cannot be able to result in large-degree carbon isotopic fractionation, indicating that carbon isotopic analysis is a feasible approach for conducting oil-source correlation works in saline lacustrine petroleum systems.
Impact of the regulation of the New Brazilian Forest Code on Health: evidence based on respiratory diseases and deforestation in the Legal Amazon
Authors: Costa Edward Martins , Nascimento José Alex Bento do , Khan Ahmad Saeed , Irffi Guilherme , de Araujo Jair Andrade 
Published: January 2024

Abstract

In 2012, the Brazilian government implemented the New Forest Code, an update to the previous code, aiming to contain deforestation and promote the sustainable use of forest resources. However, regarding the Legal Amazon region, more rigorous requirements and instruments are needed. In this context, this study measured the impact of this policy on respiratory disease hospitalizations caused by deforestation. From the estimates found with the difference-in-differences method, based on panel data between 2000 and 2019, increases in respiratory disease hospitalizations and in deforestation occurred after the enactment of this policy, possibly due to rural private properties not complying with the code, but also to deforestation on public lands. The results also suggest that the underlying mechanism of these effects was the fragile compliance with the restrictions and regulations established by the current forest code, which is the main instrument to combat deforestation in Brazil.
JEL Code: C1, I1, Q12, Q23, Q50, Q56.
Classification of fish freshness using a convolutional neural network
Authors: Flores Edwin Wilson Mamani , Huisa Roger Pedraza 
Published: January 2024

Abstract
At work, the freshness of rainbow trout (Oncorhynchus mykiss) was analyzed, this aspect being very important to determine its quality. The objective is to propose a computational model based on a CNN to classify the freshness of the trout based on changes in the color of their eyes and gills. For this purpose, a dataset of images with acquired trout was created. To obtain the results, three experiments were conducted: the first with 2 classes (days 1 and 9), the second with 3 classes (days 1, 5, and 9), and the third with 5 classes (days 1, 3, 5, 7, and 9). All experiments were carried out in Google Colab. The results were validated using a confusion matrix ROC curve. The best results were obtained by the ResNeXt5032x4d model, with 2 classes achieving an accuracy of 0.9833, with 3 classes an accuracy of 0.9222, and with 5 classes an accuracy of 0.8800.
Multi-polygenic score prediction of mathematics, reading, and language abilities independent of general cognitive ability
Authors: Procopio Francesca , Liao Wangjingyi , Rimfeld Kaili , Malanchini Margherita , von Stumm Sophie , Allegrini Andrea , Plomin Robert 
Published: January 2024

Abstract

Specific cognitive abilities (SCA) correlate genetically about 0.50, which underpins general cognitive ability (g), but it also means that there is considerable genetic specificity. If g is not controlled, then genomic prediction of specific cognitive abilities is not truly specific because they are all perfused with g. Here, we investigated the heritability of mathematics, reading, and language ability independent of g (SCA.g) using twins and DNA, and the extent to which multiple genome-wide polygenic scores (multi-PGS) can jointly predict these SCA.g as compared to SCA uncorrected for g. We created SCA and SCA.g composites from a battery of 14 cognitive tests administered at age 12 to 5,000 twin pairs in the Twins Early Development Study (TEDS). Univariate twin analyses yielded an average heritability estimate of 40% for SCA.g, compared to 53% for uncorrected SCA. Using genome-wide SNP genotypes, average SNP-based heritabilities were 26% for SCA.g and 35% for SCA. We then created multi-PGS from at least 50 PGS to predict each SCA and SCA.g using elastic net penalised regression models. Multi-PGS predicted 4.4% of the variance of SCA.g on average, compared to 11.1% for SCA uncorrected for g. The twin, SNP and PGS heritability estimates for SCA.g provide further evidence that the heritabilities of SCA are not merely a reflection of g. Although the relative reduction in heritability from SCA to SCA.g was greater for PGS heritability than for twin or SNP heritability, this decrease is likely due to the paucity of PGS for SCA. We hope that these results encourage researchers to conduct genome-wide association studies of SCA, and especially SCA.g, that can be used to predict PGS profiles of SCA strengths and weaknesses independent of g.
Cognitive and Psychiatric Relevance of
Dynamic Functional Connectivity States in a Large (N&gt;10,000) Children Population
Authors: Fu Zening , Sui Jing , Iraji Armin , Liu Jingyu , Calhoun Vince 
Published: January 2024

Abstract

Children’s brains dynamically adapt to the stimuli from the internal state and the external environment, allowing for changes in cognitive and mental behavior. In this work, we performed a large-scale analysis of dynamic functional connectivity (DFC) in children aged 9 ~ 11 years, investigating how brain dynamics relate to cognitive performance and mental health at an early age. A hybrid independent component analysis framework was applied to the Adolescent Brain Cognitive Development (ABCD) data containing 10,988 children. We combined a sliding-window approach with k-means clustering to identify five brain states with distinct DFC patterns. Interestingly, the occurrence of a strongly connected state was negatively correlated with cognitive performance and positively correlated with dimensional psychopathology in children. Meanwhile, opposite relationships were observed for a sparsely connected state. The composite cognitive score and the ADHD score were the most significantly correlated with the DFC states. The mediation analysis further showed that attention problems mediated the effect of DFC states on cognitive performance. This investigation unveils the neurological underpinnings of DFC states, which suggests that tracking the transient dynamic connectivity may help to characterize cognitive and mental problems in children and guide people to provide early intervention to buffer adverse influences.