bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beziehungsgeschichten. Kunstaffine Ärzt:innen, begabte Künstlerpatient:innen und die Debatte um Kunst aus psychiatrischem Kontext nach 1945
Authors: Beyer C. , Gümpel C. F. , Röske T. , Rotzoll M. 
Published: January 2024

Zusammenfassung
Hintergrund
1945 prägte der Künstler und Sammler J. Dubuffet den Begriff Art brut u. a. für originelle Werke von Psychiatrieinsassen, die außerhalb von Traditionen und Kunstströmungen entstanden waren. In den Jahrzehnten danach standen diese Werke im Zentrum von Aushandlungsprozessen, in die sich neben Psychiater:innen nun auch verstärkt Ausstellungsmacher:innen, Galerist:innen etc. einmischten.

Fragestellung
Anhand von vier „Beziehungsgeschichten“ zwischen Psychiater:innen und Künstlerpatient:innen (H. Müller-Suur – P. Goesch; M. in der Beeck – E. Spießbach; J. Porret-Forel – A. Corbaz; L. Navratil – R. Limberger) werden schlaglichtartig Herangehensweisen an das Spannungsfeld Kunst und Psychiatrie nach 1945 dargestellt.

Material und Methoden
Die dargestellten Ergebnisse des Teilprojektes „Normal#verrückte Kunst. Werke aus psychiatrischem Kontext zwischen Diagnostik und Ästhetik nach 1945“ der DFG-Forschungsgruppe „Normal#Verrückt“ (FOR 3031) werden durch die Auswertung von Archivbeständen, Nachlässen, Zeitzeug:inneninterviews und zeitgenössischen Medien erzielt.

Ergebnisse
Es wird gezeigt, dass die unterschiedliche Haltung der genannten Psychiater:innen zu „ihren“ Künstlerpatient:innen deren Eingang in die Kunstwelt stark beeinflussten. Wichtig waren dabei v. a. Impulse jenseits der Psychiatrie, um rein diagnostische Sichtweisen auf die Werke durch andere Zugänge zu erweitern.

Diskussion
Das erneute Interesse an der individuellen Kreativität von Patient:innen nach 1945 kann als Reaktion auf ihre Entmenschlichung im Faschismus und Nationalsozialismus verstanden werden. Jedoch konnte die Konzentration auf die pathologisierte Persönlichkeit der Künstlerpatient:innen alternative Blickwinkel auf ihre Kunst verstellen, wie auch die Verfügung über ihre Werke durch Psychiater:innen ihre Verbreitung behindern konnte.
Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study
Authors: Werkman Nikki C. C. , García-Sáez Gema , Nielen Johannes T. H. , Tapia-Galisteo Jose , Somolinos-Simón Francisco J. , Hernando Maria E. , Wang Junfeng , Jiu Li , Goettsch Wim G. , van der Kallen Carla J. H. , Koster Annemarie , Schalkwijk Casper G. , de Vries Hein , de Vries Nanne K. , Eussen Simone J. P. M. , Driessen Johanna H. M. , Stehouwer Coen D. A. 
Published: January 2024

Abstract
Aims/hypothesis
Type 2 diabetes is a highly heterogeneous disease for which new subgroups (‘clusters’) have been proposed based on disease severity: moderate age-related diabetes (MARD), moderate obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD) and severe insulin-resistant diabetes (SIRD). It is unknown how disease severity is reflected in terms of quality of life in these clusters. Therefore, we aimed to investigate the cluster characteristics and cluster-wise evolution of quality of life in the previously defined clusters of type 2 diabetes.

Methods
We included individuals with type 2 diabetes from the Maastricht Study, who were allocated to clusters based on a nearest centroid approach. We used logistic regression to evaluate the cluster-wise association with diabetes-related complications. We plotted the evolution of HbA1c levels over time and used Kaplan–Meier curves and Cox regression to evaluate the cluster-wise time to reach adequate glycaemic control. Quality of life based on the Short Form 36 (SF-36) was also plotted over time and adjusted for age and sex using generalised estimating equations. The follow-up time was 7 years. Analyses were performed separately for people with newly diagnosed and already diagnosed type 2 diabetes.

Results
We included 127 newly diagnosed and 585 already diagnosed individuals. Already diagnosed people in the SIDD cluster were less likely to reach glycaemic control than people in the other clusters, with an HR compared with MARD of 0.31 (95% CI 0.22, 0.43). There were few differences in the mental component score of the SF-36 in both newly and already diagnosed individuals. In both groups, the MARD cluster had a higher physical component score of the SF-36 than the other clusters, and the MOD cluster scored similarly to the SIDD and SIRD clusters.

Conclusions/interpretation
Disease severity suggested by the clusters of type 2 diabetes is not entirely reflected in quality of life. In particular, the MOD cluster does not appear to be moderate in terms of quality of life. Use of the suggested cluster names in practice should be carefully considered, as the non-neutral nomenclature may affect disease perception in individuals with type 2 diabetes and their healthcare providers.

Graphical Abstract
New insights into the association of air pollution and kidney diseases by tracing gold nanoparticles with inductively coupled plasma mass spectrometry
Authors: Angel Souzana , Eades Lorna J. , Sim Gavin , Czopek Alicja , Dhaun Neeraj , Krystek Petra , Miller Mark R. 
Published: January 2024

AbstractExposure to particles from air pollution has been associated with kidney disease; however, the underlying biological mechanisms are incompletely understood. Inhaled particles can gain access to the circulation and, depending on their size, pass into urine, raising the possibility that particles may also sequester in the kidney and directly alter renal function. This study optimised an inductively coupled plasma mass spectrometry (ICP-MS) method to investigate the size dependency of particle accumulation in the kidneys of mice following pulmonary instillation (0.8 mg in total over 4 weeks) to gold nanoparticles (2, 3–4, 7–8, 14 or 40 nm or saline control). Due to the smallest particle sizes being below the limit of detection in single particle mode, ICP-MS was operated in total quantification mode. Gold was detected in all matrices of interest (blood, urine and kidney) from animals treated with all sizes of gold nanoparticles, at orders of magnitude higher than the methodological limit of detection in biological matrices (0.013 ng/mL). A size-dependent effect was observed, with smaller particles leading to greater levels of accumulation in tissues. This study highlights the value of a robust and reliable method by ICP-MS to detect extremely low levels of gold in biological samples for indirect particle tracing. The finding that nano-sized particles translocate from the lung to the kidney may provide a biological explanation for the associations between air pollution and kidney disease.
Graphical Abstract
Basidiomycota strains as whole-cell biocatalysts for the synthesis of high-value natural benzaldehydes
Authors: Serra Stefano , Marzorati Stefano , Szczepańska Ewa , Strzała Tomasz , Boratyński Filip 
Published: January 2024

Abstract
Substituted benzaldehydes are the most commonly used natural-occurring flavours in the world. The consumer’s preference for ‘natural or organic’ aromas has increased the request for flavours possessing the ‘natural’ status. The resulting shortage of aromatic aldehydes of extractive origin, such as vanillin, veratraldehyde and piperonal, can be offset by developing a new biotechnological synthesis method. Here, we report a study on the microbiological reduction of five natural benzoic acid derivatives, namely p-anisic, vanillic, veratric, piperonylic and eudesmic acids, to produce the corresponding fragrant aldehydes. We found that different Basidiomycota strains can efficiently perform this transformation, with good chemical selectivity and tolerance to the toxicity of substrates and products. Besides confirming the carboxylic acid reductase activity of the already studied fungi Pycnoporus cinnabarinus, we discovered that other species such as Pleurotus eryngii, Pleurotus sapidus and Laetiporus sulphureus as well as the non-ligninolytic fungi Lepista nuda are valuable microorganisms for the synthesis of anisaldehyde, vanillin, veratraldehyde, piperonal and 3,4,5-trimethoxybenzaldehyde from the corresponding acids. According to our findings, we propose a reliable process for the preparation of the above-mentioned aldehydes, in natural form.

Key points
• Fragrant benzaldehydes were obtained by biotransformation.
• Basidiomycota strains reduced substituted benzoic acid to the corresponding aldehydes.
• Anisaldehyde, vanillin, veratraldehyde, piperonal and 3,4,5-trimethoxybenzaldehyde were prepared in natural form.

Graphical Abstract
Loop-mediated isothermal amplification linked a nanoparticles-based biosensor for detecting Epstein-Barr virus
Authors: Yang Xinggui , Zeng Xiaoyan , Huang Junfei , Yang Ludi , Mao Sha , Chen Xu , Wang Yu , Wei Xiaoyu , Li Shijun 
Published: January 2024

Abstract
Epstein-Barr virus (EBV) is a ubiquitous gamma herpesvirus that maintains a lifelong latent association with B lymphocytes. Here, a rapid and reliable diagnosis platform for detecting EBV infection, employing loop-mediated isothermal amplification (LAMP) combined with a gold nanoparticles–based lateral flow biosensors (AuNPs-LFB) (termed LAMP Amplification Mediated AuNPs-LFB Detection, LAMAD), was developed in the current study. A set of specific LAMP primers targeting the Epstein-Barr nuclear antigen (EBNA) leader protein (EBNA-LP) gene was designed and synthesized. Subsequently, these templates extracted from various pathogens and whole blood samples were used to optimize and evaluate the EBV-LAMAD assay. As a result, the limit of detection (LoD) of the EBV-LAMAD assay was 45 copies/reaction. The EBV-LAMAD assay can detect all representative EBV pathogens used in the study, and of note, no cross-reactions were observed with other non-EBV organisms. Moreover, the whole workflow of the EBV-LAMAD assay can be completed within 70 min, including rapid EBV template preparation, EBV-LAMP amplification, and AuNPs-LFB-mediated detection. Taken together, the EBV-LAMAD assay targeting the EBNA-LP gene is a rapid, simplified, sensitive, reliable, and easy-to-use detection protocol that can be used as a competitive potential diagnostic/screening tool for EBV infection in clinical settings, especially in basic laboratories in resource-limited regions.

Key points
• A novel, simplified, and easy-to-use AuNPs-LFB biosensor was designed and prepared.
• LAMP combined with an AuNPs-LFB targeting the novel EBNA-LP gene was established.
• EBV-LAMAD is a rapid, sensitive, and reliable detection protocol for EBV infection.

Graphical Abstract
Potential social facilitation through song in bird communities
Authors: Rossetto Federica , Laiolo Paola 
Published: January 2024

Abstract
The main function of birdsong is to attract mates and defend territories among conspecifics, but little is known about the potential of this behavior in generating interactions among co-existing bird species that signal at the same time. Different hypotheses have been put forward to explain the mechanisms that govern signaling in crowded acoustic spaces, including competition for acoustic space, interspecific territoriality, environmental filters, and acoustic social facilitation. We tested these hypotheses in a forest bird community by studying the behavioral, acoustic, and ecological characteristics of 13 co-occurring species. We used passive recordings to assess the magnitude and the determinants of heterospecific song co-occurrence (i.e., when different species sing at the same time and place), and playback experiments to quantify the propensity of birds to sing if stimulated by heterospecific songs. Birds more frequently sang with species with dissimilar songs. In the breeding season, they also actively sang after the playback of other species, especially if these had dissimilar songs, and occasionally after non-avian unfamiliar playbacks. Heterospecific songs may trigger song utterance because they indicate a predator-free environment, or reduce predation risk through dilution effects, and these benefits may be maximized if there is little acoustic similarity. In line with ecological theory on community assembly mechanisms, these results are compatible with limiting similarity (species with similar songs sing at different times) and suggests social facilitation between phenotypically dissimilar species. These potential biotic interactions through songs may represent a mechanism that leads to bird species coexistence and are worth exploring at the community level.

Significance statement
It is generally assumed that bird species avoid acoustic overlap with birds singing similar songs, but there is also evidence of active interspecific territoriality through song displays between pairs of species. Community-wide responses through songs have never been investigated in birds, and to fill this knowledge gap we performed both observations and experiments on multiple coexisting species. Birds tended to sing with species with more dissimilar songs and they were also actively stimulated to sing when the songs of species with dissimilar songs were played back. An interaction between species with dissimilar songs therefore emerged, potentially yielding anti-predatory benefits. Such active behavior, which would have gone unnoticed if observations only were performed, involves multiple species, and therefore may represent a community-wide mechanism of species coexistence.
A column generation approach for the lexicographic optimization of intra-hospital transports
Authors: Bärmann Andreas , Martin Alexander , Müller Alexander , Weninger Dieter 
Published: January 2024

AbstractOver the last few years, the efficient design of processes in hospitals and medical facilities has received more and more attention, particularly when the improvement of the processes is aimed at relieving the workload of medical staff. To this end, we have developed a method to determine optimal allocations of intra-hospital transports to hospital transport employees. When optimizing transport plans in hospitals, there are various optimization goals to strive for. Therefore, we used a lexicographic approach to solve this multi-criteria optimization problem. To calculate optimal transport plans in a sufficiently short computation time, we have decomposed the problem at hand with the Dantzig–Wolfe reformulation and solved the resulting pricing subproblem with an enumerative column generation approach. To improve the efficiency of the column generation process, we have investigated and implemented different pruning methods, dominance rules and a column reuse mechanism for the online setting of the application at hand. In an extensive computational study, we first evaluated the efficiency of the different pruning methods before we compared our solution approach with the standard branch-and-bound column search approach, classical column generation methods and the solution of an integrated MIP model solved by a commercial solver. Finally, we present performance indicators of the transport optimization tool, which was developed from our method and is now productively used in a German hospital.
Macular dystrophy in Kabuki syndrome due to de novo KMT2D variants: refining the phenotype with multimodal imaging and follow-up over 10 years: insight into pathophysiology
Authors: Vaclavik Veronika , Navarro Aurelie , Jacot-Guillarmod Alain , Bottani Armand , Sun Young Joo , Franco Joel A. , Mahajan Vinit B. , Smirnov Vasily , Bouvet-Drumare Isabelle 
Published: January 2024

Abstract
Background
Kabuki Syndrome is a rare and genetically heterogenous condition with both ophthalmic and systemic complications and typical facial features. We detail the macular phenotype in two unrelated patients with Kabuki syndrome due to de novo nonsense variants in KMT2D, one novel. A follow-up of 10 years is reported. Pathogenicity of both de novo nonsense variants is analyzed.

Methods
Four eyes of two young patients were studied by full clinical examination, kinetic perimetry, short wavelength autofluorescence, full field (ff) ERGs, and spectral-domain optical coherence tomography (SD-OCT). One patient had adaptive optic (AO) imaging. Whole exome sequencing was performed in both patients.

Results
Both patients had de novo nonsense variants in KMTD2. One patient had c.14843C>G; p. (Ser4948ter) novel variant and the second c.11119C>T; p. (Arg3707ter). Both had a stable Snellen visual acuity of 0.2–0.3. The retinal multimodal imaging demonstrated abnormalities at the fovea in both eyes: hyperreflectivity to blue light and a well-delimited gap—disruption of ellipsoid and interdigitation layer on OCT. The dark area on AO imaging is presumed to be absent for, or with structural change to photoreceptors. The ff ERGs and kinetic visual fields were normal. The foveal findings remained stable over several years.

Conclusion
Kabuki syndrome–related maculopathy is a distinct loss of photoreceptors at the fovea as shown by multimodal imaging including, for the first time, AO imaging. This report adds to the literature of only one case with maculopathy with two additional macular dystrophies in patients with Kabuki syndrome. Although underestimated, these cases further raise awareness of the potential impact of retinal manifestations of Kabuki syndrome not only among ophthalmologists but also other healthcare professionals involved in the care of patients with this multisystem disorder.
Host and parasite identity interact in scale-dependent fashion to determine parasite community structure
Authors: Brian Joshua I. , Aldridge David C. 
Published: January 2024

AbstractUnderstanding the ecological assembly of parasite communities is critical to characterise how changing host and environmental landscapes will alter infection dynamics and outcomes. However, studies frequently assume that (a) closely related parasite species or those with identical life-history strategies are functionally equivalent, and (b) the same factors will drive infection dynamics for a single parasite across multiple host species, oversimplifying community assembly patterns. Here, we challenge these two assumptions using a naturally occurring host–parasite system, with the mussel Anodonta anatina infected by the digenean trematode Echinoparyphium recurvatum, and the snail Viviparus viviparus infected by both E. recurvatum and Echinostoma sp. By analysing the impact of temporal parasite dispersal, host species and size, and the impact of coinfection (moving from broader environmental factors to within-host dynamics), we show that neither assumption holds true, but at different ecological scales. The assumption that closely related parasites can be functionally grouped is challenged when considering dispersal to the host (i.e. larger scales), while the assumption that the same factors will drive infection dynamics for a single parasite across multiple host species is challenged when considering within-host interspecific competition (i.e. smaller scales). Our results demonstrate that host identity, parasite identity and ecological scale require simultaneous consideration in studies of parasite community composition and transmission.
A comparison of the effects of thoracolumbar interfascial plane (TLIP) block and erector spinae plane (ESP) block in postoperative acute pain in spinal surgery
Authors: Dilsiz Pelin , Sari Sinem , Tan Kadir Berkay , Demircioğlu Murat , Topçu İsmet , Erel Varlik Kamil , Aydin Osman Nuri , Turgut Mehmet 
Published: January 2024

Abstract
Purpose
Spinal surgeries are a very painful procedure. New regional techniques for postoperative pain management are being considered. The present study aimed to evaluate the hypothesis that the ultrasound-guided erector spinae plane (ESP) block would lead to lower opioid consumption compared to the thoracolumbar interfascial plane (TLIP) block after lumbar disk surgery. The study's primary objective was to compare postoperative total opioid consumption, and the secondary objective was to assess postoperative pain scores.

Methods
Sixty-eight patients who underwent elective lumbar disk surgery were randomly assigned to either the ESP block group or the TLIP block group. The current pain status of the patients in both the ESP and TLIP block groups was assessed using the Numerical Rating Scale (NRS) at specific time intervals (30 min, 1, 6, 12 and 24 h) during the postoperative period. The number of times patients administered a bolus dose of patient-controlled analgesia, (PCA) within the first 24 h was recorded.

Results
In the ESP group, the total opioid consumption in terms of morphine equivalents was found to be significantly lower (ESP group: 7.7 ± 7.0; TLIP group: 13.0 ± 10.1; p < 0.05). The NRS scores were similar between the groups at 30 min, 1, 6, and 12 h, but at 24 h, they were significantly lower in the ESP group. Moreover, the groups had no significant difference regarding observed side effects.

Conclusion
This study demonstrated the analgesic efficacy of both techniques, revealing that the ESP block provides more effective analgesia in patients undergoing lumbar disk surgery.
Analytical Estimation of Strain Energy Accumulation in Retreating Longwall Mining and Sensitivity Analysis Using the Orthogonal Testing Method
Authors: Agrawal Harshit , Durucan Sevket , Cao Wenzhuo , Cai Wu 
Published: January 2024

AbstractExcessive strain energy accumulation in the coal seam is one of the essential conditions for rockbursts to occur. It is imperative to understand the parameters that affect the strain energy accumulation in retreating longwall mining to optimise the design and minimise rockbursts occurrences. In this paper, new analytical models were developed to calculate the strain energy accumulation considering the current state-of-the-art longwall machinery being used in the industry. Seven parameters, i.e., mining depth, length of the cantilever roof, coal seam thickness, thickness of the immediate roof, Young’s modulus of coal and the roof, and Poisson’s ratio of the coal seam, were identified as the parameters affecting the strain energy accumulation. A detailed statistical analysis of the parameters was conducted using the orthogonal testing method, which revealed that mining depth, Young's modulus of coal and the coal seam thickness significantly influence the strain energy accumulation within a 99% confidence interval.
Tumorassoziierte Epilepsie bei Gliomen
Authors: Böhm Vincent , Leibetseder Annette 
Published: January 2024

ZusammenfassungEpileptische Anfälle stellen eine häufige und die Lebensqualität stark beeinträchtigende Symptomatik bei Patient:innen mit diffusen Gliomen dar. Im Vergleich zu höhergradigen Gliomen sind niedriggradigere mit einem höheren Anfallsrisiko assoziiert. Neueste pathophysiologische Forschungsergebnisse zeigen einen engen Zusammenhang zwischen neuronaler Überaktivierung und deren tumorproliferativen Wirkung und damit zwischen epileptischer Aktivität und Tumorwachstum. Dementsprechend gilt als therapeutischer Ansatz der hirntumorassoziierten Epilepsie, die Tumormasse bestmöglich zu reduzieren und eine adäquate anfallssuppressive Medikation (ASM) zu etablieren. Insbesondere die operative Entfernung, aber auch eine Radiotherapie und/oder Chemotherapie können die Häufigkeit epileptischer Anfälle günstig beeinflussen. Die Wahl der ASM richtet sich nach verschiedenen Faktoren wie Anfallsart, Wirkmechanismus, Komorbiditäten und Nebenwirkungsprofil. In Monotherapie stellt Levetiracetam im europäischen Raum derzeit das beliebteste ASM dar. Auf die Gabe von ASM der ersten Generation sollte aufgrund starker enzymmodulierender Effekte möglichst verzichtet werden. Eine abschließende Bewertung möglicher antiproliferativer Effekte von ASM mit hemmendem Einfluss auf das Tumorwachstum lässt die derzeitige Studienlage nicht zu.Die Dauer der Behandlung wie auch der Zeitpunkt der Beendigung einer ASM bei Gliompatient:innen unterliegt einer strengen Nutzen/-Risikoabwägung und ist individuell zu treffen.Direkte Vergleichsstudien einzelner ASM wie auch detaillierte Register mit Auflistung der gewählten (Kombinations‑)Therapien sollten zukünftig forciert werden, um eine bessere Bewertung von Wirksamkeit und Verträglichkeit im Einsatz bei der hirntumorassoziierten Epilepsie zu ermöglichen.