bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal Colonization of Serine Protease esp-Positive Staphylococcus epidermidis Affecting Staphylococcus aureus
Authors: Goeun Kang  , Hyun Soo Kim  , Han-Sung Kim  , Wonkeun Song  , Jae-Seok Kim  
Published: October 2023

Background: Staphylococcus aureus is a common colonizer of the nasal vestibule found in approximately 20%–30% of healthy adults, while Staphylococcus epidermidis appears to be the most frequent colonizer in all regions of the upper respiratory tract. Esp, a serine protease of S. epidermidis, was reported to inhibit S. aureus colonization. This study was performed to examine the nasal colonization of S. aureus and S.epidermidis and the presence of esp determinants. Methods: Nasal swab specimens from 54 patients were cultured on blood agar plates (BAP) and selective media for S. aureus for bacteria isolation. After 48 hours of incubation with BAP, three or four colonies suspected of being coagulase-negative staphylococci (CNS) were identified by mass spectrometry. Polymerase chain reaction (PCR) for esp was performed on all CNS isolates identified as S. epidermidis. Results: Forty-three S.epidermidis strains were isolated from 18 (33.3%) of the 54 patients.Nine (50.0%) of the 18 patients carried S. aureus, while the other nine did not. Of the 36 S. epidermidis non-carriers, 13 (36.1%) were colonized by S. aureus. All S. epidermidis strains were confirmed by PCR to have esp determinants. Conclusion: S. epidermidis colonization did not affect S. aureus colonization in the nasal cavity. All S.epidermidis strains harbored the esp gene. There were no differences in the nasal colonization rates of S. aureus according to the presence of esp-positive S. epidermidis. Further research on the characterization of S.epidermidis in Korea is needed to understand the association between S. epidermidis and S. aureus colonization.
Towards agent-based travel demand simulation across all mobility choices – the role of balancing preferences and constraints
Authors: Scherr Wolfgang , Manser Patrick , Joshi Chetan , Frischknecht Nathalie , Métrailler Denis 
Published: October 2023

This article presents an agent-based travel demand model, where agents react to transport supply across all mobility choices. Long-term choices include mobility tool ownership and work locations. Daily travel patterns are simulated at the individual level by sequentially combining activity frequency, activity durations and destinations as well as a rule-based time-of-day scheduling. A key to success in this novel approach is balancing individual preferences of travelers with system constraints. The model incorporates two types of constraints: 1) capacity constraints of the transport infrastructure. 2) natural time and space constraints during the execution of individual 24-hour day plans. Model results are validated against empirical observations of travel demand in Switzerland. The article concludes with a perspective for further research and development in the field of applied agent-based modeling.
KEANEKARAGAMAN HAYATI, KEMANFAATAN HUTAN DAN SIMPANAN KARBON HKM SUKSES MANYAM SEJAHTERA DI LAMANDAU KALIMANTAN TENGAH
Authors: Maimunah Siti , Remario Remario , Hendriansyah Hendriansyah , F Amrin , AM Amin , Fatchurrohman A , Samek Jay H. , Supriyanto Bambang 
Published: October 2023

PT Bumitama Gunajaya Agro berkomitmen untuk mendukung masyarakat melalui Krisnawati, H., W. C. Adinugroho, and R. Imanuddin. "Monograph allometric models for estimating tree biomass at various forest ecosystem types in Indonesia." Research and Development Center for Conservation and Rehabilitation, Forestry Research and Development Agency, Ministry of Forestry, Bogor (2012).pendekatan kemitraan pengelolaan perhutanan sosial di Hutan Sukses Manyam Sejahtera(SMS). Hal ini dilakukan agar pengelola mengetahui potensi spesies, nilai manfaatnya, potensi sumber pendapatan alternatif dari hasil hutan bukan kayu dan jasa lingkungan. Melalui kegiatan ini diharapkan akan terjadi transfer pengetahuan dengan harapan pengelola memiliki kompetensi dalam mengidentifikasi dan mengelola keanekaragaman hayati. Metodologi penelitian menggunakan metode untuk menilai keanekaragaman hayati yang dibuat oleh USAID LESTARI pada tahun 2018. Hasil penelitian menunjukkan bahwa dari 62 petak dalam 1.032ha dengan intensitas pengambilan sampel 0,221% diketahui bahwa nilai rata-rata pemanfaatan hutan bagi masyarakat adalah 25,58065 dimana nilai tersebut dikategorikan bahwa hutan SMS merupakan hutan yang sehat (21-30). Kondisi hutan sebagian ditebangi secara ilegal oleh masyarakat untuk pertanian, yang masih berhutan hanya di daerah dengan kondisi topografi yang terjal, dengan kondisi hutan yang baik. Satwa liar yang ditemui sangat beragam, yaitu Haruwei. Haruwei (Merak Kalimantan), ayam hutan, beruang madu, rangkong, trenggiling, landak, babi hutan, bidawang dan ikan jejulong. Pertemuan dalam bentuk jejak kaki, pendengaran, penglihatan, sarang dan kotoran. HKm SMS menyediakan 45 spesies Flora dan fauna yang secara langsung bermanfaat bagi masyarakat dan 7 flora dan habitat unik yang bermanfaat secara budaya dan kearifan lokal. Kandungan karbon daerah ini 60.310,67 ton karbon dengan 131 spesies pohon dengan indeks Menhenick 4,01; Indeks Margalef 18,64; Indeks Shannon 4,27; Indeks Simpson 0,98 dan kemerataan 0,88. Potensi tersebut dapat dikembangkan untuk kegiatan di HKm SMS yang dapat dilakukan bersama dengan PT BGA dalam hal konservasi hutan dan peningkatan kesejahteraan masyarakat.
Kemampuan Bacillus thuringiensis untuk Mengendalikan Spodoptera frugiperda J.E. Smith
Authors: Jani Raden , Soedijo Samharinto , Liestiany Elly 
Published: October 2023

Spodoptera frugiperda adalah hama utama yang menyerang tanaman jagung sehingga perlu dilakukan upaya pengendalian. Salah satu alternatif pengendalian menggunakan agensia hayati Bacillus thuringiensis (Bt). Pada penelitian ini penggunaan agensia hayati bakteri B. thuringiensis terhadap larva S. frugiperda. Penelitian ini bertujuan untuk mengetahui kemampuan dari bakteri B. thuringiensis dalam mengendalikan S. frugiperda untuk skala di laboratorium. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 6 kali ulangan. Perlakuan menggunakan dosis 2 ml, 2,5 ml dan 3 ml bakteri B. thuringiensis serta sebagai pembanding yaitu air steril yang bertindak sebagai kontrol dalam penelitian ini. Pengamatan mortalitas dilakukan setiap 12 jam selama 96 jam. Setiap ulangan diinfestasikan 10 ekor larva S. frugiperda sehingga didapatkan 240 ekor larva S. frugiperda pada setiap unit satuan percobaan. Hasil penelitian ini menunjukkan bahwa agensia hayati bakteri B. thuringiensis pada dosis 3 ml memiliki kemampuan patogenisitas terhadap mortalitas S. frugiperda dengan persentase yaitu sebesar 23,3% dan memilki nilai Lethal Time dengan waktu terbaik yaitu 9,3 hari untuk mematikan 50% S. frugiperda.
Efektivitas Komunikasi Pemasaran Produk Gapoktan Mitra
Authors: Hanifa Distantya , Winarno Joko , Suminah Suminah 
Published: October 2023

Penelitian ini bertujuan untuk mendeskripsikan efektivitas komunikasi pemasaran produk dan mendeskripsikan variabel serta menganalisis pengaruh periklanan, promosi penjualan, personal selling (pejualan perseorangan), direct marketing(penjualan langsung), dan word of mouth baik secara simultan dan parsial terhadao efektivitas komunikasi pemasaran produk di Roko Tani Indonesia Center Yogyakarta. Penelitian menggunakan metode kuantitatif dengan pemilihan sampel secara non-probably sampling. Data dianalisis melalui analisis deskriptif, verifikatif, uji asumsi klasik, dan regresi linier berganda. Hasil menunjukkan efektivitas komunikasi pemasaran produk gapoktan mitra pada Toko Tani Indonesia Center Yogyakarta meliputi komponen pengetahuan dan behaviour change secara keseluruhan berada pada kategori tinggi. Variabel promosi penjualan, personal selling, direct marketing, dan word of mouth berpengaruh signifikan terhadap efektivitas komunikasi pemasaran produk gapoktan mitra pada Toko TaniIndonesia Center Yogyakarta. Sedangkan variabel periklanan tidak berpengaruh. Nilai koefisien determinasi (R2) sebesar 0,874, artinya 87,4% efektivitas komunikasi pemasaran produk gapoktan mitra pada TTIC Yogyakarta dapat dijelaskan oleh variabel periklanan, promosi penjualan, personal selling, direct marketing, dan word of mouth.
The Influence of Science Skills Through Scientific Learning Model In Biology Learning: A Review Study
Authors: Imtihana Ezif Rizqi , Restiana Restiana 
Published: October 2023

<p>Scientific learning is a common approach that is quite effective in learning, especially in learning biology. This research was conducted with the aim to find out (1) the influence of science skills through scientific learning models, (2) types of scientific learning models that affect students' science skills, and (3) natural science topics using scientific learning models that affect students' science skills. This research was a meta-analysis study with a qualitative approach that adopted a literature review method by Durst &amp; Edvardsson consisting of the following 4 steps. 15 articles were selected from 27 articles published in the last 5 years (2018-2022). The research article was searched using the Educational Resources Information Center (ERIC), SINTA Indonesia online database. Results of these analyses show that science skills affected through scientific learning model are 3C, thinking skill, literacy skill, and science process skill. These science skills are influenced through scientific learning model by project-based learning, problem-based learning and discovery learning. Biology topics used in this research are environment, plantae, histology, endocrine system, animal kingdom, ecosystem, and biodiversity; environment is the most commonly used topic in science learning.</p>
KUALITAS LAYANAN DAN THEORY OF PLANNED BEHAVIOR: DAMPAK PADA KEPUASAN PELANGGAN DALAM LAYANAN DRIVER ONLINE MAKANAN DI MASA PANDEMI COVID-19
Authors: Prasanti Tissa Permata , Aprilia Anisa , Dewi Heptari Elita 
Published: October 2023

<p>Masyarakat menjadi lebih konsumtif dalam hal membeli produk, terutama makanan, sebagai akibat dari pandemi COVID-19. Kondisi ini juga disebabkan oleh anjuran pemerintah agar masyarakat tidak melakukan aktivitas di luar rumah. Masyarakat tetap dapat memenuhi kebutuhan pangannya dengan menggunakan jasa pengiriman <em>online</em>.<em> </em>Tujuan penelitian adalah menganalisis kualitas layanan dan <em>planned behavior</em> terhadap kepuasan pelanggan dalam layanan <em>driver </em>online makanan di masa pandemi COVID-19. Lokasi penelitian berada di Kota Malang, Jawa Timur dengan 62 responden yang diambil dengan <em>purposive sampling. </em>Teknik analisis data menggunakan metode SEM-PLS (<em>Structural Equation Modelling-Partial Least Square)</em> dengan <em>software </em>WarpPLS 7.0.<strong> </strong>Hasil penelitian menunjukkan bahwa variabel kualitas layanan berpengaruh signifikan terhadap kepuasan pelanggan. Variabel niat sebagai variabel mediasi memiliki pengaruh signifikan terhadap kepuasan pelanggan. Variabel sikap dan norma subjektif berpengaruh signifikan terhadap niat individu. Sedangkan, variabel kontrol perilaku persepsi tidak berpengaruh signifikan terhadap niat. Berdasarkan temuan penelitian, para pelaku usaha sejenis diharapkan dapat melakukan peningkatan kualitas layanan, seperti memperhatikan rating dari pelanggan dan menghimbau <em>driver </em>untuk mengikuti SOP (<em>Standart Operating Procedure)</em>. Kemudian, pelaku usaha dapat meningkatkan kegiatan promosi dan memberikan kupon diskon dengan tujuan untuk terciptanya <em>mouth to mouth </em>di lingkungan masyarakat. Semakin individu percaya dan yakin terhadap jasa atau produk yang digunakan, maka akan terciptanya sebuah niat individu untuk melakukan pembelian produk. <strong></strong></p>
KONSUMSI MINUMAN HERBAL DAN PROBIOTIK DI KALANGAN MAHASISWA PADA MASA PANDEMI COVID-19
Authors: Halim Indah Oktavia , Rasmikayati Elly , Saefudin Bobby Rachmat 
Published: October 2023

<p align="center">Drinks are fluids that are needed by the body, these drinks are categorized into healthy drinks and sweet drinks. Drink consumption changed during the Covid-19 pandemic, which is a new virus originating from Wuhan, China with a very fast spread that has an impact on the economy, changes in social relations, and changes in lifestyle. Efforts that can be made to reduce the spread of the virus is to maintain the body's immunity, one way is by consuming healthy drinks. Although healthy drinks for students during the pandemic have increased, the consumption of sweet drinks is still favored by students and until now there are still few studies that discuss the habits of consuming healthy drinks in students. The purpose of this study was to determine of consumption of healthy drinks both before and during the Covid-19 pandemic. This study uses a quantitative descriptive design with a survey method. The study was conducted on students of the Faculty of Agriculture, Padjadjaran University batch 2020. The analytical method used was descriptive statistics with column diagrams, frequency distribution tables and cross tabulations. The results showed that there was an increase in the consumption of healthy drinks, namely herbal drinks and probiotic drinks during the Covid-19 pandemic.</p>
NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting
Authors: Sharma Swati , Ehrlich Marcelo , Zhang Manqi , Blobe Gerard , Henis Yoav 
Published: October 2023

Abstract
Endothelial cells express neuropilin 1 (NRP1), endoglin (ENG) and vascular endothelial growth factor receptor 2 (VEGFR2), which regulate VEGF-A-mediated vascular development and angiogenesis. However, the link between complex formation among these receptors with VEGF-A-induced signaling and biology was unclear. Here, we quantified surface receptor interactions by IgG-mediated immobilization of one receptor, and fluorescence recovery after photobleaching (FRAP) measurements of the mobility of another coexpressed receptor. We observed stable ENG/NRP1, ENG/VEGFR2, and NRP1/VEGFR2 complexes, which were enhanced by VEGF-A. ENG augmented NRP1/VEGFR2 interactions, suggesting formation of tripartite complexes bridged by ENG. Effects on signaling were measured in murine embryonic endothelial cells expressing (MEEC+/+) or lacking (MEEC-/-) ENG, along with NRP1 overexpression or knockdown. Optimal VEGF-A-mediated phosphorylation of VEGFR2 and Erk1/2 required ENG and NRP1. ENG or NRP1 increased VEGF-A-induced sprouting, becoming optimal in cells expressing all three receptors, and both processes were inhibited by a MEK1/2 inhibitor. We propose a model where the maximal potency of VEGF-A involves a tripartite complex where ENG bridges VEGFR2 and NRP1, providing an attractive therapeutic target for modulation of VEGF-A signaling and biological responses.
Using Artificial Neural Network for Forecasting PM2.5 Levels in a Prominent Industrial and Historically Significant Urban Center in Iran: Evaluating Health Implications
Authors: bardshahi ali mohammadi , Jaafarzadeh Neemat , Tabatabaie Tayebeh , Amiri Fazel 
Published: October 2023

Abstract
There has been a scarcity of comprehensive studies that aim to predict both the levels of PM2.5 particles and their corresponding impacts on human health. To fill this gap, we developed an artificial neural network model and AirQ+ software to predict PM2.5 concentrations and assess their associated health effects. The ANN model utilized five distinct input parameters, specifically wind velocity, wind orientation, atmospheric temperature, relative moisture content, and PM2.5 levels, observed within the time frame of 2018 to 2019. The concealed stratum comprised a total of ten neurons, in addition to the presence of an output layer. The MLP neural network demonstrated strong correlations at each stage: 0.908 (training), 0.910 (validation), 0.914 (testing), and 0.907 overall. The RMSE was determined as 6.52 µg/m3 when evaluating the neural network, thus indicating the notable predictive precision exhibited by the multilayer perceptron (MLP) neural network when forecasting the concentration of PM2.5 particles. The AirQ+ software, created by the World Health Organization (WHO), was employed to assess the magnitude and consequences of PM2.5 concentrations. The average concentration of PM2.5 particles throughout the duration of the study was recorded as 26.5 μg/m3, which exceeds the recommended limit provided by the WHO by a factor of 5.3. The study estimated the proportions and numbers of deaths attributed to various conditions. Specifically, chronic obstructive pulmonary disease (COPD), ischemic heart disease (IHD), lung cancer (LC), stroke, and all-cause mortality accounted for approximately 11.67%, 15.02%, 13.25%, 15.225%, and 9.45% respectively. The estimated number of deaths were 19,195 for all causes, 10,063 for COPD, 564 for IHD, and 1,063 for lung cancer. The findings of this investigation demonstrate a high degree of reliability in the methodologies utilized. Through the utilization of these approaches, individuals in positions of authority and responsibility can aptly evaluate the cost-benefit analysis, leading to a reduction in human casualties and mitigating the economic burdens on society.
Epidemiological, Clinical and imaging features, and outcome of patients with Crisscross heart disease: A Systematic review of 46 published case reports
Authors: Ramadan Alaa , Roshdy Merna Raafat , Hamad Abdullah Ashraf , Refaey Neveen , Abdelazeem Basel , Essam Mohamed , Soliman Mostafa A , Abdelaziz Ahmed , Shieba Yusuf 
Published: October 2023

Abstract
Background and objectives
The crisscross heart (CCH) is a rare congenital cardiac abnormality defined by the crossing of the inflow streams of the two ventricles due to the heart's apparent twisting about its long axis. Despite being considered a defect, the CCH is more of a spatial than a functional aberration, so the heart can still work normally. The severity of this anomaly is determined by the difficulty of knowing the obscurity of the etiology, the lack of early diagnosis, and the exacerbation of its symptoms. The choice of optimal surgical interventions for managing complex heart defects leads to a marked reduction in morbidity and mortality incidence. We conducted this study to provide a summary and critical evaluation of the existing evidence knowledge on the nature of this defect and to emphasize the importance of early diagnosis.
Methods
We searched PubMed, Scopus, Web of Science, and Embase databases in addition to cross-checking against the bibliographies of retrieved articles to identify additional reports until September 15th,2022.
Results
Our inclusion criteria are met by 46 case reports, which include 101 patients of both sexes ≥1 month of age, published from 1974 to 2021. CCH was diagnosed in 45 (44.6%) females and 56 (55.4%) males with a median age of 66 months [interquartile range (IQR): 12-216 months] who came from 19 countries worldwide. The common clinical features manifested with dyspnea in 17 (16.8%), cyanosis in 39 (38.6%), and tachycardia in 12 (11.9%) patients. The most common associated congenital heart diseases were ventricular septal defect in 85 (84.3%) patients, double outlet right ventricle in 52 (51.5%) patients, and pulmonary stenosis in 62 (61.4%) patients. The Surgical intervention took place in 65.4% of the patients. A two-ventricle repair may not be possible in most patients, and these patients are prepared for a Fontan-type surgery.
Conclusion
Understanding this complex congenital heart disease allows clinicians to provide their patients with the best care and prompt intervention. Further investigation of the histopathology pictures and genetic sequences is needed to determine a clear pathogenesis.
Comparison of Home Exercise Under Supervision and Self Home Exercise in Pregnant Women with Gestational Diabetes: Randomized Controlled Trial
Authors: Menek Merve Yılmaz , Kaya Ayse Kavasoglu 
Published: October 2023

Abstract
Objective Exercise programs at home are successful in treating gestational diabetes by controlling blood glucose. The aim is to compare the efficacy of the self-directed home exercise program, the standard care alone and the supervised home exercise program in pregnant women with gestational diabetes on blood glucose, quality of life and pregnancy outcomes.
Methods This randomized, parallel, single-blind study included forty-five pregnant women who were 24-28 weeks of gestation. Participants were randomly divided into the supervised home exercise group (SHEG), home exercise group (HEG) and control group (CG). While the home exercises program was taught and controlled by a physiotherapist in SHEG, the home exercise brochure was given without any training by the gynecologist in HEG. Control group maintained their usual daily care. The home exercise intervention included low to moderate structured exercise performed three days per week for 8 weeks. Their glucose responses, quality of life and pregnancy outcomes were assessed pre- and post intervention.
Results Fasting glucose and 2 h postprandial glucose levels were improved statistically in SHEG and HEG groups after intervention (p<0.05). Differences in SHEG were statistically higher than HEG (p<0.017). When the HEG and CG were compared, there was no superiority between the two groups in all outcome measures except the physical health. Additionally, there were no statistically significant differences in values of cesarean birth and preterm birth between groups (p>0.05).
Conclusions This study revealed that pregnant women should be under the supervision of physiotherapists while doing home exercises.
Clinical Trial Registration The trial was approved by the registration of ClinicalTrials.gov and registration number: NCT05195333.
Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of Inflammatory bowel disease
Authors: liu xianqiang , Li Dingchang , Gao Wenxing , Zhao Wen , Chen Peng , Liu Hao , Zhao Yingjie , Dong Guanglong 
Published: October 2023

Abstract

Objective
The literature has previously reported the associations between inflammatory bowel disease (IBD) and certain inflammatory cytokines, such as CRP, IL-1, and TNFα. To additionally evaluate the causal relationships between 41 inflammatory cytokines and IBD, a Mendelian randomization (MR) study was conducted.
Methods
The two-sample MR investigation utilized data from three large publicly available genome-wide association studies (GWAS) on IBD, ulcerative colitis (UC), and Crohn's disease (CD) genetic variants. Additionally, inflammatory cytokine data from a GWAS meta-analysis, including 8,293 healthy individuals, were incorporated into the study. Causal relationships between exposures and outcomes were predominantly determined utilizing inverse variance-weighted methods. To evaluate the heterogeneity, pleiotropy, and stability of these genetic variants, the MR-Egger intercept test, Cochran's Q test, and leave-one-out sensitivity analysis were conducted.
Results
The findings revealed that IL13 was linked to an elevated risk of IBD, UC, and CD, while MIF demonstrated a correlation with an elevated risk of CD. Conversely, TNF-related apoptosis-inducing ligand (TRAIL) was linked to a decreased risk of IBD and UC. Additionally, reverse MR analyses revealed that IBD was correlated with elevated levels of Monokine Induced by Gamma Interferon (MIG) and Stromal Cell-Derived Factor-1α (SDF1A), while UC showed an association with elevated levels of MIG and IL10. The CD was linked to elevated levels of stem cell factor (SCF) and decreased levels of TNF-β.
Conclusion
In the MR study, three upstream regulatory factors and five downstream regulatory factors were identified for IBD and its subtypes, providing avenues for developing new therapies for IBD.