bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthèse de la Dé‐Pro7‐oxytocine, de la Dé‐Leu8‐oxytocine et de la Dé‐Gly9‐oxytocine
Authors: Jaquenoud P.‐A. , Boissonnas R. A. 
Published: December 2004

AbstractThree new analogues of Oxytocin in which one of the amino‐acids of the peptidic side‐chain has been omitted, i.e. De‐Pro7‐Oxytocin, De‐Leu8‐Oxytocin and De‐Gly9‐Oxytocin, have been synthesized according to the scheme (3+5). All three analogues exhibit about 1% of the uterus contracting and milk ejecting activities of Oxytocin, but no avian depressor property.
Die Glykoside von Streblus asper LOUR. 2. Mitteilung. Glykoside und Aglykone 238. Mitteilung
Authors: Khare M. P. , Schindler O. , Reichstein T. 
Published: December 2004

AbstractDie Konstitution von Asperosid und von Streblosid wurde ermittelt. Ersteres ist Digitoxigenin‐3‐2′,3′‐di‐O‐methyl‐β‐D‐glucosid‐〈1,5〉 und Streblosid ist Strophanthidin‐3‐[2′,3′‐di‐O‐methyl‐β‐D‐glucosid‐<1,5>]. Kamalosid enthält Periplogenin als Genin; der Zucker wurde nur papierchromatographisch als 2,3‐Di‐O‐methyl‐fucose ermittelt.
Über einen graphentheoretischen Zusammenhang zwischen dem HÜCKEL'schen MO‐Verfahren und dem Formalismus der Resonanztheorie
Authors: Heilbronner E. 
Published: December 2004

AbstractThe complete set of «unexcited» polar resonance‐structures that can be written for an even π‐electron‐system containing only six‐membered rings and/or linear chains of orbitals, defines a matrix which is the inverse of the Hückel‐matrix of the same system.
Über die Verrucarine und Roridine. 2. (vorläufige) Mitteilung. Partialstruktur von Verrucarin A
Authors: Tamm Ch. , Gutzwiller J. 
Published: December 2004

AbstractThe base catalysed hydrolysis of the antibiotic verrucarin A (C27H34O9) yields three products: (1) verrucarol (C15H22O4), a new sesquiterpene which is probably bicyclic, (2) muconic acid (C6H6O4), a new sesquiterpene which is probably bicyclic, (2) muconic acid (C6H6O4; cis,cis or cis, trans) and (3) verrucarinolactone (C6H10O3), the δ‐lactone of the hitherto unknown trans‐α,δ‐dihydroxy‐β‐methylvaleric acid. The absolute configuration of verrucarinolactone is deduced by its correlation with (R)‐(+)‐methylsuccinic acid. Verrucarinic acid represents a new natural isomer of mevalonic acid.
Alkalische Spaltung der Glycosidbindung in Methyl‐digalakturonosid‐dimethylester
Authors: Heim P. , Neukom H. 
Published: December 2004

AbstractMethyl‐digalacturonosido‐dimethylester is readilly cleaved by cold sodium methylate into galacturonicacid‐methylester and an unsaturated compound identified as α‐methyl‐Δ4,5‐D‐galacturonosido‐methylester.
Komplexone XXXIII. Reaktionsenthalpie und ‐entropie bei der Bildung der Metallkomplexe von Äthylendiamin‐ und Diaminocyclohexan‐tetraessigsäure
Authors: Anderegg G. 
Published: December 2004

AbstractThe enthalphy changes involved in teh formation of teh proton and the metal complexes of enthylenediamine ‐N,N,N′,N′ tetraacetate ion and trans‐1,2‐diaminocyclohexane‐N,N,N′,N′‐ tetraacetate ion have been determined using a direct calorimetric method.
La déshydratation du trichlorométhyl–2‐butanol‐2
Authors: Thomas A. F. , Palluy E. , Willhalm B. , Stoll M. 
Published: December 2004

AbstractThe dehydration products of 2‐trichloromethyl–2‐butanol are the 2‐trichloro‐methyl–1‐and ‐2‐butenes. The first of these easily rearranges to 1, 1‐dichloro‐2‐chloro‐methyl‐1‐butene, but the allyl rearrangement product from the other is highly reactive, and gives further transformation products under the conditions used for the rearrangement.
Zur Kenntnis der sogenannten «Alkalicarbonyle» III. Die «Alkalicarbonyle» als Substangemische einer metalloganischen Verbindung und Metallacetylendiolaten
Authors: Büchner W. 
Published: December 2004

AbstractThe pyrophoric products obtained from the alkalimetals lithium, sodium, potassium, rubidium, and cesium with carbon monoxide in liquid ammonia are shown to be mixtures of the metal acetylene diolates, MOC  COM, with an organometallic compounds, the possible structures of which are discussed.
Der pro‐oxydative Effekt tumorhemmender Methylhydrazin‐Verbindungen
Authors: Berneis K. , Kofler M. , Bollag W. , Zeller P. , Kaiser A. , Langemann A. 
Published: December 2004

AbstractTumour inhibiting methylhydrazino compounds such as 1‐methyl‐2‐benzyl‐hydrazine phosphate and 1‐methyl‐2‐( p‐isopropylcarbamoyl‐benzyl)‐hydrazine hydro‐chloride in aqueous solution in the presence of molecular oxygen cause a degradation of deoxyribonucleic acid (DNA), whereby the DNA molecule is split into smaller fragments without substantial destruction of its double helix structure. This degradation is inhibited by catalase, by peroxydase and by cysteamine, whereas cysteine has only a minor influence. The degrading action on DNA of the methylhydrazino compounds is due to the formation of hydrogen peroxide during their autoxidation. From experimental evidence it is concluded that hydrogen peroxide is formed by a chain reaction with free radicals as intermediates. In the course of autoxidation of the methylhydrazino compounds, strong reducing agents are formed which can cause the formation of OH radicals from hydrogen peroxide. As is known, the latter radicals are very reactive and can cause the degradation of DNA. DNA can be used as a reagent for indicating the presence of OH radicals. It cannot be claimed at present that an attack on DNA is the deciding factor for the cytotoxic effect of the methylhydrazino compounds.
Über Dithiyliumcyanine (III). und Oxathiyliumcyanine (I)
Authors: Wizinger R. , Dürr D. 
Published: December 2004

AbstractDie Synthese einiger symmetrischer und unsymmetrischer Cyanine mit dem Benz‐l,3‐dithiylium‐, dem 5‐Äthoxy‐benz‐l,3‐dithiylium‐, dem 4,5‐Dihydro‐l, 3‐dithiylium‐ und dem Benz‐l,3‐oxathiylium‐Ring als Endglied wird beschrieben. Die Beziehungen zwischen Konstitution und Farbe werden kurz erörtert. In allen Reihen zeigen die Hemicyanine mit Dimethylaminostyrylgruppen kräftige positive Ab‐weichungen vom Mittelwert auf.
Multiple Homoallyl‐Umlagerungen bei der Hydrolyse von 3,5‐Dibrom‐tricyclo [2,2,2,02,6] octanen. Bicyclo [2,2,2] octan‐Reihe, 7. Mitteilung
Authors: Grob C. A. , Hostynek J. 
Published: December 2004

AbstractHydrolysis of the trans and exo‐cis forms of 3,5‐dibromo‐tricyclo[2,2,2,02,6]‐octane, 6 and 7 respectively, proceeds at an enhanced rate and leads exclusively to tricyclo[2,2,2,0]2,6]octane‐3,5‐endo‐cis‐diol (diol B, 31). In the presence of acid, ca 70% of this kinetically controlled product is converted into five isomeric diols, viz. bicyclo[3,2,l]oct76‐ene‐2, 8‐exo‐diol (diol A, 25), bicyclo[2,2,2]oct‐5‐ene‐2,3‐trans‐diol (diol C, 29), bicyclo[3,2,l]oct‐6‐ene‐2‐exo‐8‐endo‐diol (diol D, 27), tricyclo‐[2,2,2,02,6]octane‐3, 5‐trans‐diol (diol E, 33) and tricyclo[2,2,2,02,6]octane‐3, 5‐exo‐cis‐diol (diol F, 32).
Polarographie an Festelektroden I. Gleichspannungspolarographie von Blei an intermittierend polarisierten Festelektroden
Authors: Schmidt E. , Moser P. , Riesen W. 
Published: December 2004

AbstractEs wird die Aufnahme von Gleichspaiinungspolarogrammen von Blei aus wässerigen Chlorid‐, Bromid‐, Nitrat‐ und Acetatlösungen an intermittierend polarisierten Silber‐, Gold‐ und Platinelektroden beschrieben.
Über in 5‐Stellung basisch substituierte 5H‐Dibenzo[b,e]‐1,4‐diazepine. 2. Mitteilung über siebengliedrige Heterozyklen
Authors: Hunziker F. , Künzle F. , Schmutz J. 
Published: December 2004

AbstractEs wird die Synthese von 3 Typen in 5‐Stellung basisch substituierter 5H‐Di‐benzo[b, e]‐1, 4‐diazepine beschrieben.
Synthèse de nouveaux analogues de la lysine‐vasopressine: Asp(NH2)4‐lysine‐vasopressine, Ala4‐lysine‐vasopressine, Sér4‐lysine‐vasopressine, Sér5‐lysine‐vasopressine, Val7‐lysine‐vasopressine et (Nϵ‐For‐Lys)8‐vasopressine
Authors: Boissonnas R. A. , Guttmann St. , Huguenin R. L. , Jaquenoud P.‐A. , Sandrin Ed. 
Published: December 2004

AbstractSix new analogues of Lysine‐vasopressin have been synthesized 1 Asp(NH2)4‐lysine‐vasopressin, Ala4‐lysine‐vasopressin, Ser4‐lysine‐vasopressin, Ser5‐lysine‐vaso‐pressin, Val7‐lysine‐vasopressin and (Nϵ‐For‐Lys)8‐vasopressin. All were prepared by the 3 + 6 scheme. The hexapeptides necessary for the synthesis of the former four were prepared by recurrent synthesis, those utilized for the synthesis of the last two, by condensation of two tripeptides. The analogues substituted in position 4 were found to still possess a significant level of activity, whereas those substituted in positions 5 or 7 were almost inactive. Masking of the ϵ‐amino group of lysine in position 8 caused no decrease in the oxytocic activities, but affected, to a different degree, the pressor and the antidiuretic activities.
Über die Oxydation der Ascorbinsäure durch salpetrige Säure Teil VII. Die säurekatalysierte Reaktion in Deuteriumoxid
Authors: Dahn H. , Loewe Lotte 
Published: December 2004

AbstractIn the oxidation (= nitrosation) of ascorbic acid by the nitrous acidium ion 0,1 to 0,2 N aqueous acid, a solvent isotope effect kD/kH = 1,8 was found.
3‐O‐Methyl‐6‐desoxy‐D‐allose. Desoxyzucker, 38. Mitteilung
Authors: Krasso Anna F. , Weiss Ek. 
Published: December 2004

Abstract3‐O‐Methyl‐6‐deoxy‐D‐allose (V) and its methyl β‐D‐pyranoside (IV) have been synthesized and obtained in a crystalline state, although in low yield, starting from methyl 6‐deoxy‐β‐D‐allopyranoside (I) via the 2,4‐di‐O‐benzoyl derivative II.
Über die Autoxydation eines α‐Aminoketon‐Derivates und ihre Beeinflussung durch Metall‐Ionen
Authors: Zell R. , Erlenmeyer H. 
Published: December 2004

AbstractIt is shown that during the autoxidation of a dihydropyrazine, formed by intramolecular cyclisation of the α‐acylaminoketone RCH(COR′)NHCOCH(R)NH2 (R′ = (CH3)2CHCH2–, R = CH3CH2–), evolution of H2O2 is strongly catalysed by Mn diphosphate complexes.
Zur Kenntnis des 14‐Desoxy‐14αH‐digitoxigenins
Authors: Hauser Emil , Linde Horst , Meyer Kuno 
Published: December 2004

AbstractEs wird ein reproduzierbares Verfahren zur Bereitung von reinem 14‐Desoxy‐14αH‐digitoxigenin aus β‐Anhydrodigitoxigenin beschrieben.
Zur Konformation des Bicyclo[2.2.2]octan‐Systems
Authors: Ermer O. , Dunitz J. D. 
Published: December 2004

AbstractCrystals of bicyclo [2.2.2] octane‐1, 4‐dicarboxylic acid are monoclinic, a = 6.01 Å, b = 16.73 Å, c = 10.29 Å, β = 115.08°, space group P21/c, with 4 molecules in the unit cell. The structure was solved with the help of direct methods and refined by full‐matrix least‐squares analysis of the three‐dimensional intensity data. Within experimental error the bicyclo [2.2.2]‐octane (BCO) skeleton has apparent D3h‐symmetry, corresponding to the totally eclipsed conformation. Analysis of the thermal ellipsoids in terms of the translational and rotational motion of the BCO skeleton leads to an r.m.s. amplitude of 5.9 ± 0.2° for rotation about the threefold axis.On the assumption that the bond lengths remain effectively constant during a torsional vibration of BCO, the potential energy surface has been calculated for a range of semi‐empirical potential functions. These calculations show that the energy minimum may be slightly displaced from D3h symmetry, but if so the barrier between the two such equivalent minima is only about 0.1 kcal mole−1. The energy eigenvalues and eigenfunctions for a typical variation of potential energy vs torsion angle have been calculated. From the form of the eigenfunction of the ground vibrational state we conclude that BCO has effective D3h symmetry at all temperatures as far as diffraction methods are concerned.
Synthèse du «Propylure», phéromone sexuelle de Pectinophora gossypiella SAUNDERS
Authors: Stoll M. , Flament I. 
Published: December 2004

Abstract10‐Propyl‐trans‐trideca‐5, 9‐dien‐1‐yl acetate (propylure), the sex pheromone of the female pink bollworm moth, has been synthesized by an original procedure. The spectroscopic and physiological properties of the material are identical to that of the natural attractant.
Synthèses stéréospécifiques et étude organoleptique comparée de onze triméthyl‐2,2,3‐exo‐norbornyl‐5‐exo‐cyclohexanols racémiques
Authors: Demole Edouard 
Published: December 2004

AbstractThe stereospecific syntheses of the eleven racemic 2,2, exo‐3‐trimethyl‐exo‐5‐norbornyl‐cyclohexanols related to the formula VI have been achieved. Moreover, the fragrant properties of these isomeric and stereomeric cyclohexanols have been carefully estimated by a team of four well‐experienced perfumers. In good agreement with our earlier observations [1 ab], it was concluded that the axial 3‐(2,2, exo‐3‐trimethyl‐exo‐5‐norbornyl)‐cyclohexanols, threo (XXIV) and erythro (XXIX), are the only isomers which display a very powerful and genuine sandalwood odour. The other cyclohexanols were found to be about 20–100 times less fragrant (4 compounds), or practically odourless (5 compounds).
Synthèse électrochimique du cycle époxydique. Communication préliminaire
Authors: Gerdil Raymond 
Published: December 2004

AbstractThe polarographic behaviour of ditosyloxy alkanes TsO(CH2)nOTs in aprotic medium suggests that intramolecular cyclisation takes place after reductive cleavage of a single SO2O bond at the dropping electrode. This hypothesis was verified by controlled potential electrolysis of the lower homologues at a mercury cathode. High yields of epoxy compounds are obtained by this method.
Mesomeric Vinyl Cations. Part II. Solvolysis of 2‐bromo‐1, 3‐butadienes
Authors: Grob C. A. , Spaar R. 
Published: December 2004

AbstractIn contrast to 2‐bromo‐1, 3‐butadiene (5), the di‐, tri‐ and tetramethyl derivatives 6–11 show remarkable solvolytic reactivity. First order rate constants and products of these bromodienes in 80% ethanol have been determined. Rates are very sensitive to the ionising power of the solvent but are not affected by triethylamine. Three types of products are formed, i.e. alkenynes, α,β‐unsaturated ketones and 4‐ethoxyallenes.One methyl group on C‐4 of 5 increases the reaction rate by a factor of ca. 102; two methyl groups increase the rate by ca. 104. Methyl substituents at C‐1 have only a slight influence, apparently as a result of a rate‐decreasing polar effect and a compensating rate‐increasing steric effect.The results of this study are consistent with a unimolecular ionization mechanism involving a mesomeric vinyl cation 12a ↔ 12b as an intermediate.
Die Herstellung von 3, 5‐disubstituierten Cyclopentenen durch Ozonolyse von Norbornadien
Authors: Grob C. A. , Pfaendler H. R. 
Published: December 2004

AbstractThe ozonization of norbornadiene is described. Oxidation of the intermediate with silver oxide furnishes 4‐cyclopentene‐cis‐1, 3‐dicarboxylic acid, reduction with sodium borohydride cis‐1, 3‐bis‐hydroxymethylcyclopent‐4‐ene. The latter was converted to cis‐3, 5‐dimethylcyclopentene by reduction of the corresponding bis‐tosylate with LiAlH4. Hydrogenation of the ozonization intermediate over palladium‐lead carbonate (Lindlar's catalyst) afforded 4‐cyclopentene‐cis‐1, 3‐dialdehyde. This reaction represents a new and selective method for the reduction of unsaturated ozonization intermediates.
Addition von Enolen an negativ substituierte Benzochinone
Authors: Fumagalli S. E. , Eugster C. H. 
Published: December 2004

Abstract2‐Acetyl‐1, 4‐benzochinon und 2‐Methoxycarbonyl‐1, 4‐benzochinon setzen sich unter sehr milden Bedingungen mit Enolen (Acetessigester, Cyclohexan‐1, 2‐ und Cyclohexan1, 3‐dione) unter C‐C‐Verknüpfung um. Die entstandenen Hydrochinone wurden in substituierte Benzofuran‐3‐carbonsäureester und Cumaran‐2‐one umgewandelt. Oxydation von 2‐Methyl‐3‐acetyl‐4‐hydroxy‐benzofuran‐3‐carbonsäure‐äthylester führte zum 2‐Methyl‐benzofuran‐4, 7‐chinon‐3‐carbonsäure‐äthylester.
Eine neue Fulvensynthese. 4. Mitteilung
Authors: Kyburz R. , Schaltegger H. , Neuenschwander M. 
Published: December 2004

AbstractFulvenes are prepared by condensation of sodium cyclopentadienide with x‐acetoxy‐x‐chloro‐hydrocarbon derivatives, followed by elimination of acetic acid with triethylamine. The yields are approximately 60% for 6‐alkylfulvenes and similar to those of the classical synthesis for 6, 6‐polymethylenefulvenes. The reaction is carried out at low temperatures and under water‐free conditions. The purification of the fulvenes is simple.
Quantitative Auswertung von Gas‐Chromatogrammen partiell getrennter Stoffgemisch
Authors: Bosshard Ch. , Piringer O. , Gäumann T. 
Published: December 2004

AbstractA simple method is described for the qualitative and quantitative analysis of gas chromatograms with considerably overlapping peaks, based on the assumption of known retention indices and peak shapes. Its application to mixtures of deuteriated hydrocarbons is indicated.The extent to which the results are reproducible is shown to be about the same as that of high‐resolution gas chromatography or mass spectrometry.
11, 12‐Dihydro‐ 12‐hydroxy‐tribenzo[c,g,m]‐1,2,5,6,9,12‐hexa‐azacyclotetradecine; a Neutral Homoaromatic [14]Annulene Macrocyclic Aza Compounds, I
Authors: Skrabal P. , Zollinger H. 
Published: December 2004

AbstractThe structure of the title compound 2 is supported by spectra and analysis; homoaromaticity is deduced from its NMR. and electronic spectra.
The Electronic Spectrum of Tricyclo[3.3.0.0.2,6]octa‐3,7‐diene
Authors: Gleiter R. , Kobayashi T. 
Published: December 2004

AbstractThe unusual electronic spectrum of the title compound is shown to be due to the strong interaction between the π‐orbitals of the double bonds and the Walsh‐orbitals of the fourmembered ring.
Über Pterinchemie. 36. Mitteilung [1]. Herstellung von 6‐Aminomethyl‐6,7‐dimethyl‐5,6,7,8‐tetrahydropterin und Mechanismus seiner Oxydation unter physiologischen Bedingungen
Authors: Viscontini M. , Cogoli‐Greuter M. 
Published: December 2004

AbstractZur Herstellung von 6‐Aminomethyl‐6,7‐dimethyl‐5,6,7,8‐tetrahydropterin wurde das durch Blausäureaddition an 6,7‐Dimethyl‐7,8‐dihydropterin entstandene 6‐Cyano‐6,7‐dimethyl‐5,6,7,8‐tetrahydropterin acetyliert, reduziert und anschliessend desacetyliert. Wie das 6‐Aminomethyl‐6‐methyl‐5,6,7,8‐tetrahydropterin bildet das 6,7‐Dimethylhomologe während seiner Oxydation mit Luftsauerstoff unter physiologischen Bedingungen kein Parachinoiddihydropterin. Nach der vollständigen Oxydation wurde neben dem erwarteten 6,7‐Dimethylpterin auch 6‐Methylpterin isoliert. Der Mechanismus der 6‐Methylpterin‐Bildung wird diskutiert.
Darstellung und spektroskopische Untersuchungen von Kupferkomplexen mit verschiedenen Mikrostrukturen, III Komplexe mit dreifach koordiniertem Kupfer (II)
Authors: Ludwig W. , Textor M. 
Published: December 2004

AbstractDie Existenz monomerer Teilchen CuCl3− und CuBr3− wird bestätigt. Ihre Elektronenspektren ohne Störung durch Fremdteilchen werden mitgeteilt und auf der Basis der Molekelorbital‐Theorie interpretiert. Ausserdem wird gezeigt, dass alle theoretisch möglichen Komplexe mit gemischtem Chloro‐Bromo‐Ligandensystem existieren, und dass dreifach koordiniertes CuII weicher ist als Kupfer mit den normalen Koordinationszahlen 4 bzw. 6. In nichtkoordinierenden Lösungsmitteln sind die Teilchen planar und assoziieren sich bei den erreichbaren Konzentrationen nicht merklich. Der erste erlaubte Elektronentransfer‐Übergang ist von kleiner Halbwertsbreite und wird bei den Mischkomplexen nicht aufgespalten, sondern ändert seine Energie symbath mit der mittleren optischen Ligand‐Elektronegativität bei sukzessivem Austausch der einzelnen Halogenidliganden. In den Elektronentransferzuständen liegt demnach in Übereinstimmung mit der Erwartung aus der Molekelorbital‐Theorie eine kollektive Oxydation der Liganden vor. Relativistische Effekte (Spin‐Bahn‐Kopplung) haben selbst beim Tribromokomplex keinen auffallenden Einfluss auf das Elektronentransferspektrum. Schliesslich werden die Elektronenspektren der CuX3−‐ mit denjenigen der CuX42−‐Komplexe verglichen.
Protonenresonanzspektren von aromatischen N‐Oxiden Berechnung der chemischen Verschiebungen, verursacht durch die Feldeffekte der NO‐gruppe
Authors: Hamm P. , Philipsborn W. V. 
Published: December 2004

AbstractThe proton NMR. spectra of a series of aromatic amines, their N‐oxides and the corresponding protonated species are analysed. The results for different protons are expressed in terms of differential chemical shifts of the N‐oxide with respect to the corresponding amine or to the hydrocarbon. These data are compared with calculated shielding values obtained according to the theories of McConnell & Buckingham using published data for the magnetic susceptibilities and electric dipoles of the functional groups. The major part of the shielding by the N‐oxide group originates from the electric dipole. If one considers resonance structures for the aromatic N‐oxides the single bond structure and the double bond structure for the NO bond are of approximately equal importance.
Oxydative Demethylierung durch Leberhomogenat von Ratten nach Vitamin E‐Mangel und nach Tocopherolgaben
Authors: Bernhard K. , Markstein R. , Zimmerli W. 
Published: December 2004

AbstractZusammenfassung. Das sauerstoffabhängige demethylierende Enzymsystem aus Leberhomogenat oder Lebermikrosomenpräparaten wird durch α‐Tocopherol nicht beeinflusst. Eine deutliche, aber langsamer verlaufende Enzyminduktion nach Angewöhnung mit dem Substrat (N‐Methyl‐glutethimid) ist indessen auch in durch Vitamin E‐Mangel geschädigten Zellen nachweisbar.
The Reaction of Methyl Tosylate with Halide Ions in Pyridine‐Dimethylformamide
Authors: Müller Paul , Siegfried Bernard 
Published: December 2004

AbstractThe reactivity of the lithium halides in 83.3% pyridine‐dimethylformamide changes from Cl− > Br− > I− to Br− > I− to Br− > I− > Cl− with increasing concentration of the salt from 0 to 0.35 M. This behaviour is explained by ion pairing which reduces the concentration of reactive free nucleophiles. Equilibrium constants K for ion pair dissociation and rate constants k2 for the reaction of the free nucleophiles were determined from the variation of the observed rate constant with the total halide concentration and from conductivity measurements.
Über das Lipoxygenase‐«Lipoperoxidase»‐System in Cerealien: II. Charakterisierung des hydroperoxide‐abbauenden enzyms
Authors: Schreier P. , Heimann W. 
Published: December 2004

AbstractZusammenfassung. Durch an Hafer mit einem Ammoniumsulfatpräparat ausgeführten Untersuchungen wird bestätigt, dass am enzymatischen Linolsäurehydroperoxid (LHPO)‐Abbau eine Peroxidase beteiligt ist, welche die Bildung von Hydroxy‐cis‐trans‐dienfettsäuren aus LHPO katalysiert. Dabei fungieren die aus der H2O2‐Peroxidase‐Katalyse bekannten Verbindungen als Wasserstoffdonatoren. Durch Messungen mit p‐Phenylendiamin‐dihydrochlorid als Wasserstoffdonator werden die für das Enzym charakteristischen Eigenschaften ermittelt.
Neue β‐Lactam‐Antibiotika. Über die Darstellung der «7‐Aminocephalocillansäure». Modifikationen von Antibiotika, 4. Mitteilung [1]
Authors: Scartazzini R. , Peter H. , Bickel H. , Heusler K. , Woodward R. B. 
Published: December 2004

Abstract‘7‐aminocephalocillanic acid’ 1, an intermediate for the preparation of new β‐lactam antibiotics was prepared by transforming the β‐lactam carbinol 2a to the phosphorane 9a through several steps. Oxydation of 9a with DMSO/Ac2O led directly to the cyclized ester 11a, which has been converted into 1 by known methods.
Neue β‐Lactam‐Antibiotika. Über die Darstellung von N‐Acylderivaten der 7‐Amino‐ceph‐3‐em‐4‐carbonsäure. Modifikationen von Antibiotica, 6. Mitteilung [1]
Authors: Scartazzini R. , Bickel H. 
Published: December 2004

AbstractOxydation of 2 with iodine followed by acylation leads to β‐lactamdisulfides of type 3. Compounds 3 can be transformed into alcohols 4 by reductive alkylation with ethylenoxide and zinc/acetic acid. Compounds 4 are used as starting materials for the synthesis of N‐acylderivatives 12 of 7‐amino‐ceph‐3‐em‐4‐carboxylic acid (D).