bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of project risk allocation on PPP housing project delivery in Nigeria: partial least square structural equation modeling approach
Authors: Arijeloye Bamidele Temitope 
Published: November 2023

Purpose
This paper aims to help understand how adopting risk allocation criteria impacts the delivery of public–private partnership (PPP) mass housing in Nigeria with the view of promoting the adoption of PPP housing scheme in Nigeria.

Design/methodology/approach
The research design adopts the census sampling approach by using well-structured questionnaires distributed to stakeholders involved in PPP-procured mass housing projects, i.e. consultants, in-house professionals, contractors and the organized private sector, registered with PPP departments in the Federal Capital Territory Development Authority, Abuja, Nigeria. Sixty-three risk factors, nine risk allocation criteria and nine project delivery indices were submitted for the respondents to rank on a Likert scale of 7. Two hypotheses were formulated to test whether the risk allocation criteria impacted PPP mass housing delivery or otherwise. The study adopts partial least square-structural equation modeling to model the effect of risk on risk allocation criteria on project delivery indices and risk severity.

Findings
The finding shows that project risk allocation criteria have less effect on project delivery indices than on risk severity. The study concludes that risk allocation principles do not directly affect the delivery of PPP-procured mass housing projects. This is evident by the path coefficient of 0.724 values, which is not statistically significant at a 5% alpha protection value. The study concludes that allocating critical risk factors influences the performance of PPP-procured mass housing projects, as the path coefficient of 0.360 is also not significantly far from 0 and at a 5% alpha protection value.

Originality/value
The study is one of the recent studies conducted in PPP-procured mass housing projects in Nigeria owing to the novelty of procurement option in the sector. It highlights the risk factors that can jeopardize the PPP-procured mass housing project objectives. The study is of immense value to PPP actors in the sector by providing the necessary information required to formulate risk response methods to minimize the impact of the risk factors in PPP mass housing projects.
The ontogenetic dimension of plant functional ecology
Authors: Barton Kasey E. 
Published: November 2023

Abstract

Plant functional strategies change considerably as plants develop, driven by intraindividual variability in anatomical, morphological, physiological and architectural traits.

Developmental trait variation arises through the complex interplay among genetically regulated phase change (i.e. ontogeny), increases in plant age and size, and phenotypic plasticity to changing environmental conditions. Although spatial drivers of intraspecific trait variation have received extensive research attention, developmentally driven intraspecific trait variation is largely overlooked, despite widespread occurrence.

Ontogenetic trait variation is genetically regulated, leads to dramatic changes in plant phenotypes and evolves in response to predictable changes in environmental conditions as plants develop.

Evidence has accumulated to support a general shift from fast to slow relative growth rates and from shade to sun leaves as plants develop from the highly competitive but shady juvenile niche to the stressful adult niche in the systems studied to date.

Nonetheless, there are major gaps in our knowledge due to examination of only a few environmental factors selecting for the evolution of ontogenetic trajectories, variability in how ontogeny is assigned, biogeographic sampling biases on trees in temperate biomes, dependencies on a few broadly sampled leaf morphological traits and a lack of longitudinal studies that track ontogeny within individuals. Filling these gaps will enhance our understanding of plant functional ecology and provide a framework for predicting the effects of global change threats that target specific ontogenetic stages.

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Structural validity of nursing diagnosis insomnia in older adults of a community center
Authors: Szpalher Adriana Souza , de Souza Priscilla Alfradique , Weiss Carleara , de Oliveira Lopes Marcos Venícios , Cardoso Rosane Barreto , Silva Natália Chantal Magalhães da 
Published: November 2023

AbstractPurposeInsomnia is an important sleep disorder in older persons. Conceptual analysis studies on this nursing diagnosis have been developed, but the diagnostic accuracy has not been verified. This study aimed to verify the diagnostic accuracy of the nursing diagnosis of Insomnia (00095) in older adults in a community center in Brazil.MethodsA validation study for diagnostic accuracy of the defining characteristics of the nursing diagnosis Insomnia. Data were collected through telephone interviews with 90 participants. Latent class analysis was used to verify the sensitivity and specificity of the defining characteristics. Poisson regression was used to assess the prevalence of the association of factors related to the nursing diagnosis of insomnia.FindingsA 47.42% prevalence of insomnia in the sample was identified. Defining characteristics such as expresses dissatisfaction with sleep and nonrestorative sleep–wake cycle showed the best accuracy values for insomnia, with a specificity of 0.92 (0.78–1.00) and 0.89 (0.74–1.00), respectively. Related factors such as stressors and frequent naps during the day were more likely to develop insomnia in individuals.ConclusionsThis study indicates diagnostic accuracy of nursing diagnosis of insomnia in community‐dwelling older people from a community center. The findings highlighted the importance of the defining characteristics of nursing diagnosis insomnia and its main related factors contributing to accurate diagnostic identification.Implications for nursing practiceThis study can contribute to providing objective clinical indicators of insomnia in the older population to guide nurses in early diagnostic confirmation for the selection of health interventions. In addition, it can be a consistent contribution to theoretical and conceptual reviews of this diagnosis.
Paternal preconception exposure to non‐steroid anti‐inflammatory drugs or opioids and adverse birth outcomes: A nationwide registry‐based cohort study
Authors: Lund Ken , Garvik Olav Sivertsen , Aagaard Signe Marie , Jølving Line Riis , Larsen Michael Due , Damkier Per , Nørgård Bente Mertz 
Published: November 2023

AbstractBackground and aimPaternal use of analgesics during the time of conception and adverse birth outcomes are poorly studied. We investigated the association between paternal exposure to non‐steroid anti‐inflammatory drugs and opioids within 3 months before the date of conception and the risk of adverse birth outcomes (preterm birth, small for gestational age, low Apgar score, and major congenital malformations).MethodsWe used nationwide data from the Danish health registers. We included information on all singleton live births, and their fathers and mothers from 1997 to 2018. We created two exposed cohorts, children with preconception paternal exposure to (1) non‐steroid anti‐inflammatory drugs and (2) opioids. The unexposed cohort was children without preconception paternal exposure to non‐steroid anti‐inflammatory drugs or opioids, and we performed a sub‐analysis against paternal use of acetaminophen (paracetamol). We used logistic regression models to estimate the odds ratios of adverse birth outcomes including 95% confidence intervals.ResultsWe identified 1,260,934 children, 45,667 children with paternal exposure to non‐steroid anti‐inflammatory drugs, 10,086 children with paternal exposure to opioids, and 1,205,181 unexposed children. The adjusted odds ratio for preterm birth was 1.08 (95% confidence interval, 1.03–1.13) after paternal exposure to non‐steroid anti‐inflammatory drugs and 1.21 (95% confidence interval, 1.08–1.35) after paternal exposure to opioids. The adjusted odds ratio for small for gestational age was 1.09 (95% confidence interval, 1.03–1.17) after paternal exposure to non‐steroid anti‐inflammatory drugs, and 1.03 (95% confidence interval, 0.88–1.21) after paternal exposure to opioids. We found null‐associations for a low Apgar score and major congenital malformations. Estimates were attenuated when compared against paternal paracetamol exposure.ConclusionsOverall, we found null‐associations across the comparisons made. Weak associations were found for paternal exposure to non‐steroid anti‐inflammatory drugs or opioids and preterm birth and small for gestational age, but not with low Apgar score or major congenital malformation. All associations were attenuated when compared against an active comparator of paternal paracetamol exposure. The effect sizes were small and less likely to be of clinical relevance.
Adoption of new medicines in primary care: A comparison between the uptake of new oral anticoagulants and diabetes medicines
Authors: Dankers Marloes , Hek Karin , Mantel‐Teeuwisse Aukje K. , van Dijk Liset , Nelissen‐Vrancken Marjorie H. J. M. G. 
Published: November 2023

AimsTo gain insight in the uptake and practice variation in the prescription of 2 new medicine groups for common conditions in primary care (direct‐acting oral anticoagulants [DOACs] and incretin‐based therapies) from introduction, around 2007, to 2019 and the correlation between the adoption of those medicines in primary care.MethodsPrescription data from general practices in the Dutch Nivel Primary Care Database from 2007 to 2019 were used. The percentage of patients with prescriptions for DOACs of all patients with prescriptions for DOACs and vitamin K antagonists was calculated per practice per year, as was the percentage of patients prescribed incretin‐based therapies as a proportion of all patients with diabetes medication. Multilevel models were used to estimate practice variation for DOACs and incretin‐based therapies, expressed as intraclass correlation coefficients. Linear regression analysis was used to study the association between the prescription of DOACs and incretin‐based therapies.ResultsPer year, 46–424 general practices and 179 933–1 654 376 patients were included. In 2019, the mean percentage of patients per practice using DOACs or incretin‐based therapies was 54.9 and 9.7%, respectively. The intraclass correlation coefficient decreased from 0.75 to 0.024 for DOACs and from 0.33 to 0.074 for incretin‐based medicines during the study period. No clear correlation was found between the prescription of DOACs and incretin‐based therapies.ConclusionDOACs and incretin‐based therapies have different adoption profiles and practice variation is large, especially in the years before these medicines were introduced in guidelines. Early adopters of both medicine classes differ.
Biallelic inactivation of the NF1 tumour suppressor gene in juvenile myelomonocytic leukaemia: Genetic evidence of driver function and implications for diagnostic workup
Authors: Ramamoorthy Senthilkumar , Lebrecht Dirk , Schanze Denny , Schanze Ina , Wieland Ilse , Andrieux Geoffroy , Metzger Patrick , Hess Maria , Albert Michael H. , Borkhardt Arndt , Bresters Dorine , Buechner Jochen , Catala Albert , De Haas Valerie , Dworzak Michael , Erlacher Miriam , Hasle Henrik , Jahnukainen Kirsi , Locatelli Franco , Masetti Riccardo , Stary Jan , Turkiewicz Dominik , Vinci Luca , Wlodarski Marcin W. , Yoshimi Ayami , Boerries Melanie , Niemeyer Charlotte M. , Zenker Martin , Flotho Christian 
Published: November 2023

SummaryJuvenile myelomonocytic leukaemia (JMML) is characterized by gene variants that deregulate the RAS signalling pathway. Children with neurofibromatosis type 1 (NF‐1) carry a defective NF1 allele in the germline and are predisposed to JMML, which presumably requires somatic inactivation of the NF1 wild‐type allele. Here we examined the two‐hit concept in leukaemic cells of 25 patients with JMML and NF‐1. Ten patients with JMML/NF‐1 exhibited a NF1 loss‐of‐function variant in combination with uniparental disomy of the 17q arm. Five had NF1 microdeletions combined with a pathogenic NF1 variant and nine carried two compound‐heterozygous NF1 variants. We also examined 16 patients without clinical signs of NF‐1 and no variation in the JMML‐associated driver genes PTPN11, KRAS, NRAS or CBL (JMML‐5neg) and identified eight patients with NF1 variants. Three patients had microdeletions combined with hemizygous NF1 variants, three had compound‐heterozygous NF1 variants and two had heterozygous NF1 variants. In addition, we found a high incidence of secondary ASXL1 and/or SETBP1 variants in both groups. We conclude that the clinical diagnosis of JMML/NF‐1 reliably indicates a NF1‐driven JMML subtype, and that careful NF1 analysis should be included in the genetic workup of JMML even in the absence of clinical evidence of NF‐1.
Phase 1/2 study of CPX‐351 for patients with Int‐2 or high risk International Prognostic Scoring System myelodysplastic syndromes and chronic myelomonocytic leukaemia after failure to hypomethylating agents
Authors: Montalban‐Bravo Guillermo , Jabbour Elias , Borthakur Gautam , Kadia Tapan , Ravandi Farhad , Chien Kelly , Pemmaraju Naveen , Hammond Danielle , Dong Xiao Qin , Huang Xuelin , Schneider Heather , John Rosmy , Kanagal‐Shamana Rashmi , Loghavi Sanam , Kantarjian Hagop , Garcia‐Manero Guillermo 
Published: November 2023

SummaryFailure after hypomethylating agents (HMAs) is associated with dismal outcomes in higher risk myelodysplastic syndromes (HR‐MDS) or chronic myelomonocytic leukaemia (CMML). We aimed to evaluate the safety and preliminary activity of lower doses of CPX‐351, a liposomal encapsulation of cytarabine and daunorubicin, in a single‐centre, phase 1/2 study for patients with HR‐MDS or CMML after HMA failure. Four doses of CPX‐351 (10, 25, 50 and 75 units/m2) administered on Days 1, 3 and 5 of induction and Days 1 and 3 of consolidation were evaluated. Between June 2019 and June 2023, 25 patients were enrolled (phase 1: n = 15; phase 2: n = 10) including 19 (76%) with HR‐MDS and 6 (24%) with CMML. Most common grade 3–4 non‐haematological treatment‐emergent adverse events were febrile neutropenia (n = 12, 48%) and lung infection (n = 5, 20%). Three patients (age >75) experienced cardiac toxicity at the 75 units/m2 dose. Further enrolment continued at 50 units/m2. Four‐ and 8‐week mortality were 0% and 8% respectively. The overall response rate was 56% with median relapse‐free and overall survivals of 9.2 (95% CI 3.2–15.1 months) and 8.7 months (95% CI 1.8–15.6 months) respectively. These data suggest that lower doses of CPX‐351 are safe. Further studies are needed to evaluate its activity.
Disentangling genetic and environmental influences on early language development: The interplay of genetic propensity for negative emotionality and surgency, and parenting behavior effects on early language skills in an adoption study
Authors: Cheung Rachael W. , Austerberry Chloe , Fearon Pasco , Hayiou‐Thomas Marianna E. , Leve Leslie D. , Shaw Daniel S. , Ganiban Jody M. , Natsuaki Misaki N. , Neiderhieser Jenae M. , Reiss David 
Published: November 2023

AbstractParenting and children's temperament are important influences on language development. However, temperament may reflect prior parenting, and parenting effects may reflect genes common to parents and children. In 561 U.S. adoptees (57% male) and their birth and rearing parents (70% and 92% White, 13% and 4% African American, and 7% and 2% Latinx, respectively), this study demonstrated how genetic propensity for temperament affects language development, and how this relates to parenting. Genetic propensity for negative emotionality inversely predicted language at 27 months (β = −.15) and evoked greater maternal warmth (β = .12), whereas propensity for surgency positively predicted language at 4.5 years (β = .20), especially when warmth was low. Parental warmth (β = .15) and sensitivity (β = .19) further contributed to language development, controlling for common gene effects.
Young children's adaptive partner choice in cooperation and competition contexts
Authors: Grueneisen Sebastian , Török Georgina , Wathiyage Don Anushari , Ruggeri Azzurra 
Published: November 2023

AbstractChoosing adequate partners is essential for cooperation, but how children calibrate their partner choice to specific social challenges is unknown. In two experiments, 4‐ to 7‐year‐olds (N = 189, 49% girls, mostly White, data collection: 03.2021–09.2022) were presented with partners in possession of different positive qualities. Children then recruited partners for hypothetical tasks that differed with respect to the quality necessary for success. Children and the selected partner either worked together toward a common goal or competed against each other. From age 5, children selectively chose individuals in possession of task‐relevant qualities as cooperative partners while avoiding them as competitors. Younger children chose partners indiscriminately. Children thus learn to strategically adjust their partner choice depending on context‐specific task demands and different social goals.
Medikamente als Auslöser Bradykinin‐vermittelter Angioödeme – mehr als ACE‐Hemmer
Authors: Lochbaum Robin , Hoffmann Thomas K. , Greve Jens , Hahn Janina 
Published: November 2023

ZusammenfassungBradykinin‐vermittelte Angioödeme sind seltene, nichtallergische und potenziell lebensbedrohliche Krankheiten. Die beiden bekanntesten Formen sind das ACE‐Hemmer‐induzierte Angioödem und das hereditäre Angioödem (HAE). Die therapeutischen Möglichkeiten, die Pathophysiologie und die Diagnostik werden weiter erforscht, wobei beim HAE in den letzten Jahrzehnten erhebliche Fortschritte erzielt wurden. Für alle Patienten mit Bradykinin‐vermittelten Angioödemen gibt es Medikamente, die vermieden oder mit Vorsicht verabreicht werden sollten. Einige dieser auslösenden Medikamente sind gut bekannt, bei anderen wird ein Zusammenhang vermutet oder ihre Bedeutung ist unbekannt. Ein gemeinsamer Nenner ist, dass es keine zugelassene Therapie für das Bradykinin‐vermittelte Angioödem als Arzneimittelnebenwirkung gibt. Bei einigen Medikamenten, wie dem gewebespezifischen Plasminogenaktivator, ist die Inzidenz von Angioödemen mit möglicher Beeinträchtigung der Atemwege höher als bei ACE‐Hemmern, wobei diese Tatsache weitgehend unterschätzt wird. In dieser Übersichtsarbeit fassen wir zusammen, was derzeit über die Begleitmedikation bei HAE‐Patienten und die Interaktion mit anderen Bradykinin‐beeinflussenden Medikamenten bekannt ist und empfohlen wird.
Hautbeteiligung bei Infektionen mit Mycobacterium haemophilum: Zwei Fallberichte und eine aktualisierte Literaturübersicht
Authors: Yasen Dilidaer , Liu Chaocheng , Mei Xingxing , Zhou Hui , Tang Xuhua , Chen Xiaohong 
Published: November 2023

ZusammenfassungMycobacterium haemophilum (MH) ist ein langsam wachsendes, nicht‐tuberkulöses Mykobakterium. Infektionen treten am häufigsten bei Patienten mit beeinträchtigtem Immunsystem auf; sie manifestieren sich meist an der Haut und kommen isoliert oder bei disseminierten Infektionen vor. Wir berichten hier über einen Fall mit isolierter MH‐Infektion an der Hand sowie über einen weiteren Fall von disseminierter MH‐Infektion mit multiplen Hautläsionen. Zusätzlich haben wir weitere Fallberichte über MH‐Infektionen mit kutaner Beteiligung aus den letzten zehn Jahren (2011–2022) ausgewertet. Die am häufigsten beobachteten Hautmanifestationen der insgesamt 79 Fälle waren Knötchen, Ulzera, Abszesse, Schwellungen und Pusteln. Patienten mittleren Alters mit iatrogener Immunsuppression durch Glucocorticoide, Mycophenolat‐Mofetil, Ciclosporin und Cyclophosphamid scheinen besonders anfällig für MH‐Infektionen zu sein und haben auch ein höheres Risiko für eine Dissemination in die inneren Organe. Disseminierte MH‐Infektionen manifestieren sich gewöhnlich als Tenosynovitis, Arthritis/Arthralgie oder Osteomyelitis. Derzeit gibt es keine starke Evidenz für bestimmte Therapeutika; in der Praxis wird am häufigsten eine Dreifachkombination aus Chinolon, Makroliden und Rifampicin eingesetzt. Die Prognose ist allgemein gut. Iatrogene Immunsuppression, Läsionen im proximalen Bereich der Extremitäten sowie disseminierte Manifestation sind mit schlechteren klinischen Verläufen assoziiert.
KI‐basierte Bestimmung des PRO‐Scores in aktinischen Keratosen anhand von LC‐OCT‐Bilddatensätzen
Authors: Thamm Janis R. , Daxenberger Fabia , Viel Théo , Gust Charlotte , Eijkenboom Quirine , French Lars E. , Welzel Julia , Sattler Elke C. , Schuh Sandra 
Published: November 2023

ZusammenfassungHintergrundMit Hilfe des histologischen PRO‐Scores (I–III) kann das Risiko einer malignen Transformation aktinischer Keratosen (AK) abgeschätzt werden, indem er das Ausmaß der Undulation und basalen Proliferation der dermoepidermalen Junktionszone (DEJ) bewertet. Die konfokale Line‐Field optische Kohärenztomographie (LC‐OCT) ermöglicht eine nichtinvasive Bestimmung des PRO‐Scores in Echtzeit. Anhand von LC‐OCT‐Bilddatensätzen kann eine künstliche Intelligenz (KI) mit Hilfe von Convolutional Neural Networks (CNN) zur automatischen Quantifizierung des PRO‐Scores von AK in vivo trainiert werden.Patienten und MethodikConvolutional Neural Networks wurden trainiert, um LC‐OCT‐Bilder von gesunder Haut und von AK zu segmentieren. PRO‐Score‐Modelle wurden in Übereinstimmung mit dem histopathologischen Goldstandard entwickelt und an einer Teilmenge von 237 LC‐OCT‐AK‐Bildern trainiert und an 76 Bildern getestet, wobei der von der KI‐berechnete PRO‐Score mit dem visuellen Konsens der Bildgebungsexperten verglichen wurde.ErgebnisseEine signifikante Übereinstimmung wurde in 57/76 (75%) Fällen festgestellt. Die KI‐basierte Bewertung des PRO‐Scores korrelierte am besten mit dem visuellen Score für PRO II (84,8%) vs. PRO III (69,2%) vs. PRO I (66,6%). In 25% der Fälle kam es zu Fehlinterpretationen, die meist auf eine Verschattung der DEJ sowie störende Merkmale wie Haarfollikel zurückzuführen waren.SchlussfolgerungenDie Ergebnisse deuten darauf hin, dass CNN für die automatische Quantifizierung des PRO‐Scores in LC‐OCT‐Bilddatensätzen hilfreich sind. Dies könnte zur nichtinvasiven Bewertung des Proliferationsrisikos in der Diagnostik und Nachsorge von AK herangezogen werden.
Education in exile: Ukrainian refugee students in the schooling system in Poland following the Russian–Ukrainian war
Authors: Herbst Mikołaj , Sitek Michał 
Published: November 2023

AbstractFollowing the Russian war of aggression in Ukraine since February 2022, Poland adopted institutional solutions and policies to facilitate the inclusion of Ukrainian refugees in the schooling system. We analyse geographical patterns and local determinants of the participation of children and young people from Ukraine in education in Poland. Applying a computer‐based geographic information system and statistical analysis to administrative data from schools and municipalities in Poland, we found that about 50% of the Ukrainian refugees at schools in Poland are of primary school age, while the rates for other age groups are significantly lower. Ukrainian refugees are more likely to attend public schools in affluent urban municipalities and places with more developed accommodation infrastructure. Clearly, the role of local resources was of key importance in the territorial distribution of refugee families in Poland during the first year of the war. Another factor that proved to be important in attracting refugees was the presence of pre‐war Ukrainian immigrants in schools. Observed patterns differ between spring and autumn 2022, which partly reflects the changes in migration to Poland and then back to Ukraine. We anticipate that much of the Ukrainian migration to Poland may outlast the current conflict. This situation creates further challenges for education in Poland—and even more so for Ukraine.