bluuebunny/crossref_metadata_2025_split huggingface dataset:
A videoconferencing verification method for enrollment of breastfeeding dyads to an online prospective mixed methods study during the COVID‐19 pandemic
Authors: Wood Natsuko K. , Bindler Ross J. 
Published: November 2023

AbstractAimsTo apply videoconferencing as a new verification method prior to enrollment for an online survey‐based study.DesignA prospective‐observational, mixed methods, three group, repeated measures study involved recruiting a population‐based sample of breastfeeding mothers and infants (N = 81). Twenty‐seven mothers were recruited for each group: mothers returning to work outside of the home, mothers returning to work from home and mothers staying home with their infants full‐time.MethodsData were collected at four time points, infant age 4, 12, 20 and 24 weeks, via online survey. Participating mothers received a $10 gift card for completing each survey. Social media, word of mouth and brochures promoted United States‐based recruitment nationwide. A publicly available direct link to the survey was initially provided to interested mothers. After the suspicion of online fraud, videoconferencing was instituted for self‐referrals and phone calls for professional referrals.ResultsThe survey was invaded by response fraud 3 weeks after the initial survey deployment. Out of 109 respondents who visited the survey site during that timeframe, only eight mothers (10%) were eligible (22 June 2022 to 14 July 2022). After recruitment modification, 313 individuals emailed the study team with 65 self‐referred mothers (80%) enrolled in the study via videoconferencing while eight mothers (10%) had a professional referral and enrolled via phone call (23 August 2022 to 30 March 2023).ConclusionProviding a direct survey link, even with CAPTCHA‐protection, evoked fraudulent responses. Videoconferencing is an emerging verification method that can be readily applied to the enrollment of breastfeeding dyads for an online study.ImpactThe emergence of fraudulent respondents and internet bots threatens data quality. This study addressed the strategy of videoconferencing as a new verification method for recruitment and enrollment of breastfeeding dyads. This knowledge can be applied by researchers to secure sample validity and data integrity.
How perceived discrimination and professional rejection sensitivity impact women's career success
Authors: Reyes Denise L. , Dinh Julie , Granillo‐Velasquez Kenneth , Luna Miguel , Hebl Mikki , Salas Eduardo 
Published: November 2023

AbstractProfessional rejection is a widespread phenomenon—most, if not all, of us have or will experience it in our lifetimes. However, some are more adept at handling it than others. This paper examines individual differences in how people interpret and handle professional rejection, proposing a construct called professional rejection sensitivity. We focused on whether this construct predicts decreased self‐promoting behaviors and increased self‐silencing behaviors and, subsequently, whether that impacts career success for junior faculty. Moreover, we investigated whether women may be disproportionally predisposed to professional rejection sensitivity because they tend to experience more discrimination in the workplace than men. We collected self‐report data (i.e., individual differences) and biodata (i.e., curriculum vitae) from 300 junior faculty and found evidence of gender differences, such that women perceive more discrimination and report higher professional rejection sensitivity than men. We also found that individuals who are higher in professional rejection sensitivity are more likely to practice self‐silencing behaviors, and individuals who perceive more discrimination have lower career success. This paper serves as the first step in demonstrating the existence of professional rejection sensitivity, which can guide future research that addresses how individuals can overcome this disposition. To support this path of research, we conclude with suggestions for potential interventions.
Managing ventricular arrhythmias and implantable cardiac defibrillator shocks after left ventricular assist device implantation
Authors: Soni Bosky , Gopinathannair Rakesh 
Published: November 2023

AbstractContinuous flow left ventricular assist devices (CF‐LVADs) have been shown to reduce mortality and morbidity in patients with advanced heart failure with reduced ejection fraction. However, ventricular arrhythmias (VA) are common, are mostly secondary to underlying myocardial scar, and have a higher incidence in patients with pre‐LVAD VA. Sustained VA is well tolerated in the LVAD patient but can result in implantable defibrillator (ICD) shocks, right ventricular failure, hospitalizations, and reduced quality of life. There is limited data regarding best practices for the medical management of VA as well as the role for procedural interventions in patients with uncontrolled VA and/or ICD shocks. Vast majority of CF‐LVAD patients have a preexisting cardiovascular implantable electronic device (CIED) and ICD and/or cardiac resynchronization therapies are continued in many. Several questions, however, remain regarding the efficacy of ICD and CRT following CF‐LVAD. Moreover, optimal CIED programming after CF‐LVAD implantation. Therefore, the primary objective of this review article is to provide the most up‐to‐date evidence and to provide guidance on the clinical significance, pathogenesis, predictors, and management strategies for VA and ICD therapies in the CF‐LVAD population. We also discuss knowledge gaps as well as areas for future research.
microRNA‐365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3
Authors: Jiang Chao , Liu Youjun , Zhao Weigong , Yang Yimin , Ren Zhiwei , Wang Xiaohui , Hao Dingjun , Du Heng , Yin Si 
Published: November 2023

AbstractThis present study is aimed to investigate the role of microRNA‐365 (miR‐365) in the development of intervertebral disc degeneration (IDD). Nucleus pulposus (NP) cells were transfected by miR‐365 mimic and miR‐365 inhibitor, respectively. Concomitantly, the transfection efficiency and the expression level of miRNA were detected by quantitative reverse transcription polymerase chain reaction (qRT‐PCR). Meanwhile, NP cells apoptosis was measured through propidium iodide (PI)‐AnnexinV‐fluorescein isothiocyanate (FITC) apoptosis detection kit. Subsequently, immunofluorescence (IF) staining was performed to assess the expression of collagen II, aggrecan and matrix metalloproteinase 13 (MMP‐13). In addition, bioinformatic prediction and Luciferase reporter assay were used to reveal the target gene of miR‐365. Finally, we isolated the primary NP cells from rats and injected NP‐miR‐365 in rat IDD models. The results showed that overexpression of miR‐365 could effectively inhibit NP cells apoptosis and MMP‐13 expression and upregulate the expression of collagen II and aggrecan. Conversely, suppression of miR‐365 enhanced NP cell apoptosis and elevated MMP‐13 expression, but decreased the expression of collagen II and aggrecan. Moreover, the further data demonstrated that miR‐365 mediated NP cell degradation through targeting ephrin‐A3 (EFNA3). In addition, the cells apoptosis and catabolic markers were increased in NP cells when EFNA3 upregulated. More importantly, the vivo data supported that miR‐365‐NP cells injection ameliorated IDD in rats models. miR‐365 could alleviate the development of IDD by regulating NP cell apoptosis and ECM degradation, which is likely mediated by targeting EFNA3. Therefore, miR‐365 may be a promising therapeutic avenue for treatment IDD through EFNA3.
Institutional investors and mispricing of unionized firms
Authors: Lantushenko Viktoriya , Marciukaityte Dalia , Szewczyk Samuel H. 
Published: November 2023

AbstractWe examine investment by different types of institutional investors in firms with strong labor unions. We find that hedge funds own a lower percentage of shares in these firms than in other firms. In contrast, passive institutional investors and institutional investors as a group own a higher percentage. Our tests suggest that the relation between unionization and hedge fund ownership is causal: When union power changes in a firm, hedge fund ownership changes in the opposite direction. Instead, passive investor holdings in unionized firms seem to be driven by other firm characteristics.
The impact of the COVID‐19 pandemic on Positive Health among older adults in relation to the complexity of health problems
Authors: van der Klei Veerle M. G. T. H. , Moens Isabelle S. , Simons Twan , den Elzen Wendy P. J. , Mooijaart Simon P. , Gussekloo Jacobijn , Trompet Stella , Drewes Yvonne M. 
Published: November 2023

AbstractBackgroundThe broad concept of health as “the ability to adapt and self‐manage in the face of social, physical and emotional challenges” has been operationalized by “Positive Health,” a framework increasingly used in the Netherlands. We explored to what degree the impact of the COVID‐19 pandemic and preventive measures on Positive Health differed between community‐dwelling older adults without, with mild and with complex health problems, as well as differences flowing from their use of preventive measures.MethodsDuring the second wave in the Netherlands (November 2020–February 2021), a convenience sample of adults aged ≥65 years completed an online questionnaire. Positive Health impact was measured based on self‐reported change of current health status, across six dimensions, compared to before the pandemic (decreased/unchanged/increased). The complexity of health problems (past month) was assessed using the validated ISCOPE tool, comparing subgroups without, with mild or with complex health problems. High use of preventive measures was defined as ≥9 of 13 measures and compared to low use (<9 measures).ResultsOf the 2397 participants (median age 71 years, 60% female, and 4% previous COVID‐19 infection), 31% experienced no health problems, 55% mild health problems, and 15% complex health problems. Overall, participants reported a median decrease in one Positive Health dimension (IQR 1–3), most commonly in social participation (68%). With an increasing complexity of health problems, subjective Positive Health declined more often across all six dimensions, ranging from 3.3% to 57% in those without, from 22% to 72% in those with mild, and from 47% to 75% in those with complex health problems (p‐values for trend <0.001; independent of age and sex). High users of preventive measures more often experienced declined social participation (72% vs. 62%, p < 0.001) and a declined quality of life (36% vs. 30%, p = 0.007) than low users, especially those with complex health problems.ConclusionAs the complexity of health problems increased, the adverse impact of the COVID‐19 pandemic and related preventive measures was experienced more frequently across all dimensions of Positive Health. Acknowledging this heterogeneity is pivotal to the effective targeting of prevention and healthcare to those most in need.
Comparative severe dermatologic toxicities of immune checkpoint inhibitors in malignant melanoma: A systematic review and network meta‐analysis
Authors: Mao Yun‐tao , Wang Ying , Chen Xiao‐Xiao , Liu Cheng‐jiang , Bao Qi 
Published: November 2023

AbstractBackgroundImmune checkpoint inhibitors (ICIs) have advanced the therapeutic landscape for malignant melanoma patients. However, they can cause permanent and irreversible dermatologic immune‐related adverse events (irAEs) that may lead to interruption of ICI treatment or become life‐threatening. To assess the risk of severe dermatologic irAEs (grade 3 or higher) among ICIs for advanced melanoma, we conducted a network meta‐analysis (NMA).MethodsPhase II/III randomized controlled clinical trials (RCTs) involving ICIs were retrieved from various databases, including PubMed, Embase, Cochrane Library, and Web of Science. These trials were published from the inception of databases to October 15, 2022. In addition, the risk of severe dermatologic irAEs associated with ICI types and doses was evaluated and compared by NMA.ResultsThis study included 20 Phase II/III RCTs with a total of 10 575 patients. The results indicated that ICIs carry a higher risk of severe dermatologic irAEs compared to chemotherapy. Additionally, the combinational therapy of Nivolumab + Ipilimumab was associated with a higher risk than ICI monotherapy. Comparatively, the latest treatment option involving dual ICI therapy with Relatlimab + Nivolumab showed a lower toxicity risk, but higher than Ipilimumab alone. Lastly, Nivolumab, at a dose of 3 mg/kg every 2 weeks, was observed as the lowest‐risk dosing regimen for severe dermatologic irAEs in patients with advanced melanoma.ConclusionThe findings suggest that Nivolumab (1 mg/kg) + Ipilimumab (3 mg/kg) administered every 3 weeks should be used cautiously in patients with advanced melanoma at high risk for dermatologic irAEs. While we recommend the preferred regimen of Nivolumab (dose = 3 mg/kg, every 2 weeks).
Post‐operative nursing activities to prevent wound complications in patients undergoing colorectal surgeries: A scoping review
Authors: Tobiano Georgia , Chaboyer Wendy , Tong Mavis Ying Ting , Eskes Anne M. , Musters Selma C. W. , Colquhoun Janelle , Herbert Georgina , Gillespie Brigid M. 
Published: November 2023

AbstractAimsTo identify postoperative interventions and quality improvement initiatives used to prevent wound complications in patients undergoing colorectal surgeries, the types of activities nurses undertake in these interventions/initiatives and how these activities align with nurses' scope of practice.DesignA scoping review.Data SourcesThree health databases were searched, and backward and forward citation searching occurred in April 2022. Research and quality improvement initiatives included focussed on adult patients undergoing colorectal surgery, from 2010 onwards. Data were extracted about study characteristics, nursing activities and outcomes. The ‘Dimensions of the scope of nursing practice’ framework was used to classify nursing activities and then the Patterns, Advances, Gaps, Evidence for practice and Research recommendations framework was used to synthesise the review findings.ResultsThirty‐seven studies were included. These studies often reported negative wound pressure therapy and surgical site infection bundle interventions/initiatives. Nurses' scope of practice was most frequently ‘Technical procedure and delegated medical care’ meaning nurses frequently acted under doctors' orders, with the most common delegated activity being dressing removal.ConclusionThe full extent of possible interventions nurses could undertake independently in the postoperative period requires further exploration to improve wound outcomes and capitalise on nurses' professional role.Impact Statement

Nurses' role in preventing postoperative wound complications is unclear, which may inhibit their ability to influence postoperative outcomes.

In the postoperative period, nurses undertake technical activities, under doctors' orders to prevent wound infections.

For practice, nurses need to upkeep and audit their technical skills. New avenues for researchers include exploration of independent activities for postoperative nurses and the outcomes of these activities.

Implications for the Profession and/or Patient CareThere may be opportunities to broaden nurses' scope of practice to act more autonomously to prevent wound complication.Reporting MethodScoping Reviews (PRISMA‐ScR) checklist.Patient or Public ContributionA health consumer interpreted the data and prepared the manuscript.
Lung ultrasound score in dogs and cats: A reliability study
Authors: Oricco Stefano , Medico Daniele , Tommasi Ilaria , Bini Richard Marcello , Rabozzi Roberto 
Published: November 2023

AbstractBackgroundLung ultrasound (LUS) is a noninvasive tool for examining respiratory distress patients. The lung ultrasound score (LUSS) can be used to quantify and monitor lung aeration loss with good reliability.Hypothesis/ObjectivesAssess the reliability of a new LUSS among raters with different levels of experience and determine how well the same raters agree on identifying patterns of LUS abnormalities.AnimalsForty LUS examinations of dogs and cats and 320 videos were reviewed from a digital database.MethodsRetrospective reliability study with post hoc analysis. Protocolized LUS were randomly selected; intrarater and interrater reliability of the LUSS and pattern recognition agreement among 4 raters with different levels of experience in LUS were tested.ResultsThe intrarater intraclass correlation coefficient (ICC) single measurement, absolute agreement, and 2‐way mixed effects model was 0.967 for the high‐experience rater (H‐Exp), 0.963 and 0.952 for the medium‐experience raters (M‐Exp‐1; M‐Exp‐2), and 0.950 for the low‐experience rater (L‐Exp). The interrater ICC average measurement, absolute agreement, and 2‐way random effects model among the observers was 0.980. The Fleiss' kappa (k) values showed almost perfect agreement (k = 1) among raters in identifying pleural effusion and translobar tissue‐like pattern, strong agreement for A‐lines (k = 0.881) and B‐lines (k = 0.806), moderate agreement (k = 0.693) for subpleural loss of aeration, and weak agreement (k = 0.474) for irregularities of the pleural line.Conclusions and Clinical ImportanceOur results indicate excellent intra‐ and interrater reliability for LUS scoring and pattern identification, providing a foundation for the use of the LUSS in emergency medicine and intensive care.
Beyond the dominant voices: Unveiling Latin American perspectives on the international order
Authors: Malacalza Bernabé 
Published: November 2023

AbstractThe concept of international order has undergone significant evolution, but the dominant voices of great powers have often overshadowed regional perspectives, particularly in Latin America. Still, this region has played a crucial role in shaping the contemporary discourse on the international order. Today, the term is used in various contexts within Latin America, reflecting the increasing presence of nonstate actors and the interdependent nature of societies and the planet overall. This article focuses on Latin American diplomacy and civil society's understandings of international order, contending that the region has developed analytical and practical approaches that converge into a normative vision centered on international justice. Both the analytical and practical approaches view the international order as a normative concept. Civil society especially perceives the international order as a practice concept, utilizing its voice and actions as instruments for change. Yet, civil society is not monolithic, and various groups seek different outcomes. This article reviews critically analytical and normative perspectives of the international order, providing a comprehensive understanding of Latin American viewpoints through various data collection methods.
Front Cover
Authors: Shalaby Sarah , Ronzoni Luisa , Hernandez‐Gea Virginia , Valenti Luca 
Published: November 2023

The cover image is based on the Review The genetics of portal hypertension: Recent developments and the road ahead by Sarah Shalaby et al., https://doi.org/10.1111/liv.15732 Image Credit: Anna Shalaby
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Jeptha Knob, Kentucky, a probable meteorite impact structure
Authors: Schedl Andrew 
Published: November 2023

AbstractJeptha Knob is a deformed structure, 4.5 km in diameter, composed entirely of carbonate rocks in the stable craton of North America. At Jeptha Knob, conventional evidence of meteorite impact, shock metamorphism, has not been found. I used calcite twin analysis to test the hypothesis that Jeptha Knob is a meteorite impact crater. Calcite twinning gives differential stresses of >170 MPa in rocks that were 600 to ≈800 m below the surface when the rocks were deformed. Under these conditions, high differential stresses cannot be explained by tectonic processes. In addition, twin intensities are >150 twins/mm which are >50% higher than the highest twin intensities observed in limestone from a wide variety of tectonic settings. Twin intensities and differential stresses are the same magnitudes as those found at Serpent Mound, a proven impact structure. Consistent with meteorite impact, differential stresses increase toward the center of the structure. If one accepts that Jeptha Knob is a marine impact crater, then (1) the presence of high temperature (>250°C) thick twins in calcite from a resurge deposit; (2) the extensive dolomitization of the central uplift with water/rock ratios >1.0; and (3) two episodes of calcite twin recorded incremental strains, are explained.
Oomycete effector AVRblb2 targets cyclic nucleotide‐gated channels through calcium sensors to suppress pattern‐triggered immunity
Authors: Lee Soeui , Lee Hye‐Young , Kang Hui Jeong , Seo Ye‐Eun , Lee Joo Hyun , Choi Doil 
Published: November 2023

Summary

Transient and rapid increase in cytosolic Ca2+ plays a crucial role in plant–pathogen‐associated molecular pattern (PAMP)‐triggered immunity (PTI). Cyclic nucleotide‐gated channels (CNGCs) have been implicated in mediating this Ca2+ influx; however, their regulatory mechanisms remain poorly understood.

Here, we have found that AVRblb2 requires the calmodulin (CaM) and calmodulin‐like (CML) proteins as co‐factors to interact with the NbCNGCs, resulting in the formation of AVRblb2‐CaM/CML‐NbCNGCs complex. Furthermore, CaM and CML are dissociated from NbCNGC18 during PTI response to increase Ca2+ influx; however, Avrblb2 inhibits calcium channel activation by disrupting the release of CaM and CML from NbCNGC18.

Following recognition of PAMP, NbCNGC18 forms active heteromeric channels with other NbCNGCs, which may give selectivity of CNGC complex against diverse signals for fine‐tuning of cytosolic Ca2+ level to mediate appropriate responses. Silencing of multiple NbCNGCs compromised the function of AVRblb2 on the pathogenicity of Phytophthora infestans, confirming that AVRblb2 contributes to pathogen virulence by targeting CNGCs.

Our findings provide new insights into the regulation of CNGCs in PTI and the role of pathogen effectors in manipulating host cell physiology to promote infection.