bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Polifarmasi dan Potensi Interaksi Obat Antihipertensi Pada Pasien Rawat Jalan di RSUD dr. Soehadi Prijonegoro Sragen
Authors: Kumalasari Adisty , Endrawati Susi , Wahyuningsih Sri Saptuti , Indrasari Tika 
Published: January 2025

Hipertensi adalah kondisi tekanan darah melebihi batas normal, merupakan penyakit tidak menular, tetapi menjadi masalah kesehatan yang signifikan. Kejadian hipertensi sering kali disertai dengan penyakit lain, yang meningkatkan potensi terjadinya polifarmasi pada pasien. Polifrmasi merujuk pada penggunaan obat dalam satu resep dengan jumlah yang banyak. Penelitian ini bertujuan untuk mengetahui hubungan antara polifarmasi dan potensi interaksi obat antihipertensi pada pasien rawat jalan di RSUD dr.Soehadi Prijonegoro Sragen. Jenis penelitian yang digunakan adalah non-eksperimental, dengan pengambilan data retrospektif. Populasi penelitian adalah seluruh lembar resep pasien rawat jalan di RSUD dr. Soehadi Prijonegoro Sragen periode Juli – Desember 2023 sebanyak 1256 lembar resep. Sampel yang diambil 92 lembar resep sesuai kriteria inklusi. Teknik pengambilan sampel dengan menggunakan simple random sampling. Variabel yang diteliti meliputi jumlah jenis obat dan potensi interaksi obat antihipertensi. Instrumen yang digunakan adalah checklist dan aplikasi drugs.com. Analisis statistik dilakukan menggunakan software SPSS versi 26 dengan uji Chi-Square. Hasil penelitian menunjukkan bahwa dari 92 sampel, 75% memilki potensi interaksi obat antihipertensi, dengani nilai ? = 0,000. Kesimpulannya, golongan obat yang paling banyak digunakan adalah Beta-blockers, khususnya bisoprolol dengan 75% resep menunjukkan potensi interaksi positif dan 25% tidak menunjukkan potensi interaksi. Terdapat hubungan antara polifarmasi dan potensi interaksi obat antihipertensi pada pasien rawat jalan di RSUD dr. Soehadi Prijonegoro Sragen.
HUBUNGAN ANEMIA DENGAN KEJADIAN PENDARAHAN POSTPARTUM DI RSUD BIMA TAHUN 2024
Authors: Linda yulianti  , Tri Yubiah  , Muhd. Firmansyah  
Published: January 2025

Anemia atau yang dikenal oleh masyarakat Indonesia dengan istilah kurang darah merupakan masalah kesehatan yang ditandai dengan penurunan kadar hemoglobin dari batas normal. Angka Kematian Ibu di Indonesia masih tinggi dibandingkan dengan Negara ASEAN lainnya. Angka Kematia Ibu di negara-negara Asean sudah menempati posisi 40-60 per 100.000 kelahiran hidup. Sedangkan di Indonesia masih menempati posisi 305 per 100.000 kelahiran hidup (Survei Penduduk Antar Sensus 2020). Untuk menganalisis hubungan Anemia dengan kejadian pendarahan postpartum di RSUD Bima tahun 2024. Jenis penelitian yang digunakan adalah penelitian Kuantitatif, rancangan penelitian deskriptif korelasional dengan menggunakan pendekatan Cross Sectional. Populasi pada penelitian ini adalah Ibu Postpartum di RSUD Bima tahun 2024 berjumlah 724 orang. Pengambilan sampel 88 ibu Postpartum menggunakan teknik purposive sampling, analisis bivariat menggunakan uji chi-square, dengan menggunakan p value < 0,05. Menunjukkan bahwa responden yang anemia sebanyak 66 responden (75%), tidak anemia sebanyak 22 responden (25%), pendarahan sebanyak 68 responden (77.3%) dan tidak pendarahan sebanyak 20 responden (22.7%) RSUD Bima tahun 2024. Berdasarkan Hasil analisa data dengan menggunakan uji Chi-squer diperoleh p value = 0,008 berarti lebih kecil dari α = 0,05 dengan demikian Ha diterima. Dalam hal ini dikatakan bahwa ada hubungan anemia dengan kejadian pendarahan postpartum di RSUD Bima tahun 2024.
Relationships among COVID-19 causal factors perceived by children, basic psychological needs and social anxiety
Authors: González-García Higinio , Álvarez-Kurogi Leandro , Prieto Andreu Joel , Tierno Cordón Javier , Castro López Rosario , Salas Sánchez Jesús 
Published: January 2025

Background
The pandemic caused by COVID-19 had a great impact on our society as the lives of children have been affected, as well as their psychological health and social anxiety.

Objective
To examine whether COVID-19 causal factors perceived by children predicted basic psychological needs and social anxiety, and if basic psychological needs predicted social anxiety.

Methods
A sample of 58 schoolchildren (Mage = 10.18; SD = 0.77; 36 boys, 22 girls) participated in the study and completed a series of self-report measures. The relationship between the study variables was examined using partial least square path modelling (PLS-PM).

Results
Social distancing and protection were found to significantly reduce competence satisfaction. Perceived psychological impact significantly negatively predicted relatedness satisfaction and significantly positively autonomy frustration and competence frustration. Perceived psychological impact significantly negatively predicted anxiety in the interaction with the opposite sex. Autonomy satisfaction significantly positively predicted anxiety in the interaction with the opposite sex. Autonomy frustration significantly positively predicted anxiety in public speaking interaction with teachers, significantly positively anxiety in the interaction with the opposite sex, significantly positively anxiety of being embarrassed or ridiculed and significantly positively anxiety in the interaction with strangers.

Conclusion
Perceived psychological impact was the causal factor that revealed a higher impact on basic psychological needs. As such, it is important to take measures with children in pandemic situations to minimize this variable. On the other hand, Autonomy frustration revealed a higher impact on social anxiety. Thus, it is necessary to emphasize autonomy in children respecting the restrictions imposed to minimize the impact of social anxiety.
A narrative review on the role of cognition, nutrition and energy availability in athletes of competitive sports to combat RED-S
Authors: M. Subalatha , Rachaveti Dhanush , S. Amutha , M. Ponpandi 
Published: January 2025

Background
In the present scenario, competitive sports require athletes to achieve a phenomenal balance between cognitive abilities, motor skills, nutritional intake, and energy deficiencies. Such stability would enable the athletes to excel in their sporting field. Evidence shows that athletes develop specific cognitive abilities based on their sporting field. Nutrition is vital in creating an athlete’s cognitive ability and physical needs required to participate in competitive sports. The reduction in the intake of nutrients required before, after and during sports participation could result in relative energy deficiency in sports (RED-S), affecting the parts of the body.

Methods
The rationale behind the survey is to understand the role of nutrition and energy deficiency on the athletes’ cognitive abilities. The review’s research areas were identified as athletes’ cognition and nutrition in the context of RED-S. Search keywords were found based on the research area, such as “cognitive”, “nutrition”, and “energy deficiency/availability” in athletes. The search keywords were combined to form search queries (SQs). SQs were used to carry out the search on the Web of Science and Scopus databases.

Results
Sports play an important role in athletes’ cognitive abilities, such as decision-making, attention, memory, etc. Nutritional intakes, such as caffeinated, carbohydrate, alkaline, and protein-based supplements and diets, also significantly affect athletes’ cognitive and motor abilities. Low energy availability (LEA) causes cognitive and physical health problems in both female and male athletes.

Conclusion
The review identified that nutrition and LEA play crucial roles in athletes’ cognitive performance. Deficits in nutritional intake and energy availability lead to RED-S. Hence, cognitive performance could be used as an early indication to identify the nutritional and energy deficits in advance, enabling athletes to combat RED-S.
Exploring the Barriers to Proper Management of Personal Protective Equipment (PPE) During a Pandemic in Hospitals
Authors: Ajuwon Margaret , Chen Guangming 
Published: January 2025

Background: Effective management of personal protective equipment (PPE) in healthcare settings is critical, especially during health crises like the COVID-19 pandemic. This study aims to identify barriers to effective PPE utilization and assess the impact of training frequency on PPE management.
Methods: Using quantitative and qualitative analyses, the study evaluated 100 survey responses and performed a chi-square test to examine associations between role types and training frequencies.
Results: Findings revealed that only 59% of respondents received yearly PPE training, with inadequate preparation, insufficient knowledge, and high costs identified as primary barriers.
Conclusion: Addressing these barriers through improved training and resource management is essential for enhancing PPE effectiveness and ensuring the safety of healthcare workers and patients.
Melanoma Incidence Rates Among Non-Hispanic American Indian/Alaska Native Individuals, 1999-2019
Authors: Townsend Julie S. , Melkonian Stephanie C. , Jim Melissa A. , Holman Dawn M. , Buffalo Melissa , Julian Anne K. 
Published: December 2023

ImportanceNon-Hispanic American Indian/Alaska Native people have the second highest incidence rate of invasive cutaneous melanoma in the US after non-Hispanic White people.ObjectiveTo examine invasive cutaneous melanoma incidence rates and trends over time among non-Hispanic American Indian/Alaska Native people.Design, Setting, and ParticipantsThis descriptive, observational cross-sectional study used population-based cancer registry data (US Cancer Statistics AI/AN Incidence Analytic Database) linked to the Indian Health Service administrative database to examine incidence rates by age, sex, region, histology, tumor site, stage, and other demographic and clinical characteristics. The study examined trends from 1999 to 2019 time period by age, sex, stage at diagnosis, and region. Non-Hispanic American Indian/Alaska Native people 15 years and older who received a diagnosis of invasive cutaneous melanoma from 1999 to 2019 who were members of federally recognized tribes and resided in Indian Health Service purchased/referred care delivery areas were included in this study to reduce racial misclassification and provide more accurate rates. The data were analyzed in 2022.ExposuresDemographic and clinical characteristics, such as age, sex, geographic region, histology, stage, and tumor site.Main Outcomes and MeasuresInvasive cutaneous melanoma incidence rates by age group, sex, region, resident county characteristics (poverty level, rurality, education level, and socioeconomic status), stage at diagnosis, tumor site, and histology. Trends over time by age, sex, region, and stage.ResultsFrom 1999 to 2019, 2151 non-Hispanic American Indian/Alaska Native people (1021 female individuals [47.5%]) received a diagnosis of incident cutaneous melanoma (rate, 10.7 per 100 000; 95% CI, 10.3-11.2). Rates were higher among male than female individuals (13.0 [95% CI, 12.2-13.8] vs 9.2 [95% CI, 8.6-9.8]) and for people 55 years and older (24.2; 95% CI, 22.8-25.7) compared with those aged 15 to 39 years (3.5; 95% CI, 3.2-3.9). Rates were highest for male individuals 55 years and older (34.5; 95% CI, 31.8-37.3) and people living in the Southern Plains (male individuals: 23.8; 95% CI, 21.5-26.2; female individuals: 15.5; 95% CI, 14.0-17.2) and Pacific Coast region (male individuals: 16.5; 95% CI, 14.5-18.7; female individuals: 12.3; 95% CI, 10.9-13.9). Rates increased among female individuals from 1999 to 2019 (average annual percent change [AAPC], 2.5; P &amp;lt; .001); among regional/distant stage tumors (AAPC, 2.5; P = .01) and people 55 years and older (AAPC, 2.8; P = .001).Conclusions and RelevanceThe results of this study suggest that additional studies could potentially identify risk factors among non-Hispanic American Indian/Alaska Native people.
ED Visits for Schizophrenia Spectrum Disorders During the COVID-19 Pandemic at 5 Campus Health Systems
Authors: Singh Parvati , Nawaz Saira , Seiber Eric E. , Bryant Ian , Moon Kyle , Wastler Heather , Breitborde Nicholas J. 
Published: December 2023

ImportanceAlthough substantial research has reported grave population-level psychiatric sequelae of the COVID-19 pandemic, evidence pertaining to temporal changes in schizophrenia spectrum disorders in the US following the pandemic remains limited.ObjectiveTo examine the monthly patterns of emergency department (ED) visits for schizophrenia spectrum disorders after the onset of the COVID-19 pandemic.Design, Setting, and ParticipantsThis observational cohort study used time-series analyses to examine whether monthly counts of ED visits for schizophrenia spectrum disorders across 5 University of California (UC) campus health systems increased beyond expected levels during the COVID-19 pandemic. Data included ED visits reported by the 5 UC campuses from 2016 to 2021. Participants included persons who accessed UC Health System EDs had a diagnosis of a psychiatric condition. Data analysis was performed from March to June 2023.ExposuresThe exposures were binary indicators of initial (March to May 2020) and extended (March to December 2020) phases of the COVID-19 pandemic.Main Outcomes and MeasuresThe primary outcome was monthly counts of ED visits for schizophrenia spectrum disorders. International Statistical Classification of Diseases and Related Health Problems, Tenth Revision diagnosis codes, categorized within Clinical Classification Software groups, were used to identify ED visits for schizophrenia spectrum disorders and all other psychiatric ED visits, from the University of California Health Data Warehouse database, from January 2016 to December 2021. Time-series analyses controlled for autocorrelation, seasonality, and concurrent trends in ED visits for all other psychiatric conditions.ResultsThe study data comprised a total of 377 872 psychiatric ED visits, with 37 815 visits for schizophrenia spectrum disorders. The prepandemic monthly mean (SD) number of ED visits for schizophrenia spectrum disorders was 519.9 (38.1), which increased to 558.4 (47.6) following the onset of the COVID-19 pandemic. Results from time series analyses, controlling for monthly counts of ED visits for all other psychiatric conditions, indicated 70.5 additional ED visits (95% CI, 11.7-129.3 additional visits; P = .02) for schizophrenia spectrum disorders at 1 month and 74.9 additional visits (95% CI, 24.0-126.0 visits; P = .005) at 3 months following the initial phase of the COVID-19 pandemic in California.Conclusions and RelevanceThis study found a 15% increase in ED visits for schizophrenia spectrum disorders within 3 months after the initial phase of the pandemic in California across 5 UC campus health systems, underscoring the importance of social policies related to future emergency preparedness and the need to strengthen mental health care systems.
Low-Carbohydrate Diet Macronutrient Quality and Weight Change
Authors: Liu Binkai , Hu Yang , Rai Sharan K. , Wang Molin , Hu Frank B. , Sun Qi 
Published: December 2023

ImportanceThe associations of low-carbohydrate diets (LCDs) with long-term weight management remains unclear, and the source and quality of macronutrients within LCDs are less explored.ObjectivesTo prospectively examine associations between changes in LCD indices and weight change among US adults.Design, Setting, and ParticipantsThis prospective cohort study included initially healthy participants at baseline from the Nurses’ Health Study (NHS; 1986-2010), Nurses’ Health Study II (NHSII; 1991-2015), and Health Professionals Follow-up Study (HPFS; 1986-2018). Data analysis was performed between November 2022 and April 2023.ExposuresFive LCD indices were examined: (1) a total LCD (TLCD) emphasizing overall lower carbohydrate intake; (2) an animal-based LCD (ALCD) that emphasized animal-sourced protein and fat; (3) a vegetable-based LCD (VLCD) that emphasized plant-sourced protein and fat; (4) a healthy LCD (HLCD) emphasizing less refined carbohydrates, more plant protein, and healthy fat; and (5) an unhealthy LCD (ULCD) emphasizing less healthful carbohydrates, more animal protein, and unhealthy fat.Main Outcomes and MeasuresThe outcome of interest was 4-year changes in self-reported body weight.ResultsA total of 123 332 participants (mean [SD] age, 45.0 [9.7] years; 103 320 [83.8%] female) were included in this study. The median carbohydrate intake (as a percentage of energy) of the highest quintiles of TLCD score at baseline ranged from 38.3% in HPFS to 40.9% in NHSII. Mean weight gain over 4-year intervals among participants varied from 0.8 kg in the HPFS to 1.8 kg in the NHSII. After adjusting for demographics and baseline and concomitant changes of selected lifestyle factors, each 1-SD increase in TLCD score was associated with 0.06 (95% CI, 0.04-0.08) kg more weight gain over the 4-year periods. Similarly, participants gained 0.13 (95% CI, 0.11 to 0.14) kg per each 1-SD increase in ALCD score and 0.39 (95% CI, 0.37 to 0.40) kg per each 1-SD change in ULCD score. In contrast, each 1-SD increase in VLCD score was associated with 0.03 (95% CI, 0.01 to 0.04) kg less weight gain, and each 1-SD increase in HLCD score was associated with 0.36 (95% CI, 0.35 to 0.38) kg less weight gain. The associations were more pronounced among obese individuals (per 1-SD increase in HLCD score: BMI ≥30, 0.88 [95% CI, 0.80, 0.97] kg less weight gain; BMI &amp;lt;25, 0.23 [95% CI, 0.20, 0.26] kg less weight gain; P for interaction &amp;lt; .001).Conclusions and RelevanceThese findings suggest that the quality of LCDs may play a critical role in modulating long-term weight change. Only LCDs that emphasized high-quality protein, fat, and carbohydrates from whole grains and other plant-based foods were associated with less weight gain.
Comparison of Capture Rates of the National Cancer Database Across Race and Ethnicity
Authors: Satpathy Yasoda , Nam Percival , Moldovan Matthew , Murphy James D. , Wang Luke , Derweesh Ithaar , Rose Brent S. , Javier-DesLoges Juan 
Published: December 2023

ImportanceThe National Cancer Database (NCDB) is an invaluable and widely used resource for cancer research, but the current state of representation of different racial and ethnic groups compared with the United States Cancer Statistics (USCS) database is unknown.ObjectiveTo examine whether Hispanic and American Indian or Alaska Native individuals have lower representation in the NCDB compared with the USCS database.Design, Setting, and ParticipantsThis multicenter, retrospective cohort study assessed individuals diagnosed with breast, colorectal, lung, and prostate cancer from January 1, 2004, to December 31, 2006, and January 1, 2017, to December 31, 2019, in the NCDB and USCS databases. Data analysis was performed from September 2022 to October 2023.ExposureTime.Main Outcomes and MeasuresThe primary outcome was the absolute percentage change (APC) in capture rate across the study period.ResultsThe cohort included 5 175 007 individuals (0.50% American Indian or Alaska Native, 3.10% Asian or Pacific Islander, 12.01% Black, 6.58% Hispanic, and 77.81% White) who were diagnosed with breast, colorectal, lung, and prostate cancer. Capture rates were the lowest for individuals who were Hispanic (40.83% in 2004-2006 and 54.75% in 2017-2019; P &amp;lt; .001) or American Indian or Alaska Native (20.72% in 2004-2006 and 41.41% in 2017-2019; P &amp;lt; .001). The APCs were positive for both racial categories across all 4 cancers. However, overall APCs for Hispanic individuals (13.92%) remained lower than the overall APCs of White individuals (22.23%; P &amp;lt; .001). The APCs were greater for American Indian or Alaska Native individuals than for White individuals for prostate (14.68% vs 11.57%) and breast (21.61% vs 17.90%) cancer (P &amp;lt; .001), but the APCs for American Indian or Alaska Native individuals were lower than for White individuals for lung cancer (24.54% vs 33.03%; P &amp;lt; .001).Conclusions and RelevanceIn this cohort study of individuals diagnosed with cancer in the NCDB, Hispanic and American Indian or Alaska Native individuals diagnosed with breast, colorectal, lung, and prostate cancer were undercaptured in the NCDB, but their representation improved over time. Increased study is needed to determine where these populations predominantly seek cancer care.
Magnetic Seed vs Guidewire Breast Cancer Localization With Magnetic Lymph Node Detection
Authors: Pantiora Eirini , Jazrawi Allan , Hersi Abdi-Fatah , Abdsaleh Shahin , Ahlstedt Hanna , Molnar Eva , Wärnberg Fredrik , Eriksson Staffan , Karakatsanis Andreas 
Published: December 2023

ImportanceGuidewires have been the standard for breast lesion localization but pose operative and logistic challenges. Paramagnetic seeds have shown promising results, but to the authors’ knowledge, no randomized comparison has been performed.ObjectiveTo determine whether the combination of a paramagnetic seed and superparamagnetic iron oxide (SPIO) is equivalent to guidewire and SPIO for breast cancer localization and sentinel lymph node detection (SLND).Design, Setting, and ParticipantsThis was a phase 3, pragmatic, equivalence, 2-arm, open-label, randomized clinical trial conducted at 3 university and/or community hospitals in Sweden from May 2018 to May 2022. Included in the study were patients with early breast cancer planned for breast conservation and SLND. Study data were analyzed July to November 2022.InterventionsParticipants were randomly assigned 1:1 to a paramagnetic seed or a guidewire. All patients underwent SLND with SPIO.Main Outcomes and MeasuresRe-excision rate and resection ratio (defined as actual resection volume / optimal resection volume).ResultsA total of 426 women (median [IQR] age, 65 [56-71] years; median [IQR] tumor size, 11 [8-15] mm) were included in the study. The re-excision rate was 2.90% (95% CI, 1.60%-4.80%), and the median (IQR) resection ratio was 1.96 (1.15-3.44). No differences were found between the guidewire and the seed in re-excisions (6 of 211 [2.84%] vs 6 of 209 [2.87%]; difference, −0.03%; 95% CI, −3.20% to 3.20%; P = .99) or resection ratio (median, 1.93; IQR, 1.18-3.43 vs median, 2.01; IQR, 1.11-3.47; P = .70). Overall SLN detection was 98.6% (95% CI, 97.1%-99.4%) with no differences between arms (203 of 207 [98.1%] vs 204 of 206 [99.0%]; difference, −0.9%; 95% CI, −3.6% to 1.8%; P = .72). More failed localizations occurred with the guidewire (21 of 208 [10.1%] vs 4 of 215 [1.9%]; difference, 8.2%; 95% CI, 3.3%-13.2%; P &amp;lt; .001). Median (IQR) time to specimen excision was shorter for the seed (15 [10-22] minutes vs 18 [12-30] minutes; P = .01), as was the total operative time (69 [56-86] minutes vs 75.5 [59-101] minutes; P = .03). The experience of surgeons, radiologists, and surgical coordinators was better with the seed.Conclusions and RelevanceThe combination of SPIO and a paramagnetic seed performed comparably with SPIO and guidewire for breast cancer conserving surgery and resulted in more successful localizations, shorter operative times, and better experience.Trial RegistrationISRCTN.org Identifier: ISRCTN11914537