bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cine magnetic resonance imaging predicts thrombus adhesion in metastatic renal cell carcinoma with an inferior vena cava tumor thrombus: A case of pathological complete response with pembrolizumab plus lenvatinib
Authors: Hara Takuto , Furukawa Junya , Tsutiya Takahiro , Kodama Takayuki , Uehara Keiichiro , Terakawa Tomoaki , Harada Kenichi , Teishima Jun , Nakano Yuzo , Fujisawa Masato 
Published: November 2023

IntroductionRenal cell carcinoma with an inferior vena cava tumor thrombus is a challenging disease that requires a multimodal treatment approach. Pembrolizumab plus lenvatinib has displayed promising efficacy in metastatic renal cell carcinoma.Case presentationA 61‐year‐old man was diagnosed with metastatic renal cell carcinoma and a tumor thrombus adhering to the inferior vena cava wall by cine magnetic resonance imaging. After 6 months of pembrolizumab and lenvatinib therapy, tumor shrinkage was detected, excluding the advanced portion of the inferior vena cava thrombus, and nephrectomy and thrombectomy were performed. Adhesion of the tumor thrombus to the inferior vena cava wall was observed during surgery. Resection produced a remarkable pathological complete response with no viable cells in the resected specimens, including the thrombus site.ConclusionThis case highlights the potential of pembrolizumab plus lenvatinib for treating advanced renal cell carcinoma with an inferior vena cava thrombus and the utility of cine magnetic resonance imaging for evaluating thrombus adhesion to the inferior vena cava.
Enhancing the dung beetle iDNA tool for mammalian biodiversity monitoring and ecological studies
Authors: Nimalrathna Thilina S. , Fan Huan , Quan Rui‐Chang , Nakamura Akihiro 
Published: November 2023

AbstractMany species of dung beetles (Coleoptera: Scarabaeidae: Scarabaeinae) are coprophages and possess trophic connections with mammalian dung. Recent studies have shown that the use of genetic information from dung beetle guts (invertebrate‐derived DNA or iDNA) allows for the detection of mammals in a given habitat without intensively surveying the area. However, these studies used live or freshly killed beetles instead of preserved specimens. Here, we assessed the feasibility of extracting and sequencing iDNA from dung beetles that were collected using conventional baited pitfall traps with a mixture of propylene glycol and ethanol. We extracted iDNA from the guts of 18 dung beetles, comprising three species and three functional groups, collected from a seasonal tropical forest in Xishuangbanna, China. Eight mammalian species were detected, including rare species not previously recorded at the same location. Among the three functional groups, paracoprids (tunnelers) yielded the highest number of mammal species. Our study shows that iDNA can be successfully sequenced from preserved specimens, provided they are stored under appropriate conditions. The proposed technique offers a viable alternative to traditional cafeteria experiments for understanding dung beetle‐mammal interactions and can serve as a valuable complementary approach to current mammal survey techniques.
Using anti‐PD‐L1 antibody conjugated gold nanoshelled poly (Lactic‐co‐glycolic acid) nanocapsules loaded with doxorubicin: A theranostic agent for ultrasound imaging and photothermal/chemo combination therapy of triple negative breast cancer
Authors: Jiang Hui , Zhou Yingying , Zheng Dongdong , Cheng Yexiazi , Xiang Dacheng , Jiang Lixin , Du Jing 
Published: November 2023

AbstractTriple negative breast cancer (TNBC) has the worst prognosis of all breast cancers, and it is difficult to progress through traditional chemotherapy. Therefore, the treatment of TNBC urgently requires agents with effective diagnostic and therapeutic capabilities. In this study, we obtained programmed death‐ligand 1 (PD‐L1) antibody conjugated gold nanoshelled poly(lactic‐co‐glycolic acid) (PLGA) nanocapsules (NCs) encapsulating doxorubicin (DOX) (DOX@PLGA@Au‐PD‐L1 NCs). PLGA NCs encapsulating DOX were prepared by a modified single‐emulsion oil‐in‐water (O/W) solvent evaporation method, and gold nanoshells were formed on the surface by gold seed growth method, which were coupled with PD‐L1 antibodies by carbodiimide method. The fabricated DOX@PLGA@Au‐PD‐L1 NCs exhibited promising contrast enhancement in vitro ultrasound imaging. Furthermore, DOX encapsulated in NCs displayed good pH‐responsive and photo‐triggered drug release properties. After irradiating 200 μg/mL NCs solution with a laser for 10 min, the solution temperature increased by nearly 23°C, indicating that the NCs had good photothermal conversion ability. The targeting experiments confirmed that the NCs had specific target binding ability to TNBC cells overexpressing PD‐L1 molecules. Cell experiments exhibited that the agent significantly reduced the survival rate of TNBC cells through photochemotherapy combination therapy. As a multifunctional diagnostic agent, DOX@PLGA@Au‐PD‐L1 NCs could be used for ultrasound targeted contrast imaging and photochemotherapy combination therapy of TNBC cells, providing a promising idea for early diagnosis and treatment of TNBC.
Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis
Authors: Lozano‐Andrés Estefanía , Enciso‐Martinez Agustin , Gijsbers Abril , Ridolfi Andrea , Van Niel Guillaume , Libregts Sten F. W. M. , Pinheiro Cláudio , van Herwijnen Martijn J. C. , Hendrix An , Brucale Marco , Valle Francesco , Peters Peter J. , Otto Cees , Arkesteijn Ger J. A. , Wauben Marca H. M. 
Published: November 2023

AbstractExtracellular vesicles (EVs) in blood plasma are recognized as potential biomarkers for disease. Although blood plasma is easily obtainable, analysis of EVs at the single particle level is still challenging due to the biological complexity of this body fluid. Besides EVs, plasma contains different types of lipoproteins particles (LPPs), that outnumber EVs by orders of magnitude and which partially overlap in biophysical properties such as size, density and molecular makeup. Consequently, during EV isolation LPPs are often co‐isolated. Furthermore, physical EV‐LPP complexes have been observed in purified EV preparations. Since co‐isolation or association of LPPs can impact EV‐based analysis and biomarker profiling, we investigated the presence and formation of EV‐LPP complexes in biological samples by using label‐free atomic force microscopy, cryo‐electron tomography and synchronous Rayleigh and Raman scattering analysis of optically trapped particles and fluorescence‐based high sensitivity single particle flow cytometry. Furthermore, we evaluated the impact on flow cytometric analysis in the presence of LPPs using in vitro spike‐in experiments of purified tumour cell line‐derived EVs in different classes of purified human LPPs. Based on orthogonal single‐particle analysis techniques we demonstrate that EV‐LPP complexes can form under physiological conditions. Furthermore, we show that in fluorescence‐based flow cytometric EV analysis staining of LPPs, as well as EV‐LPP associations, can influence quantitative and qualitative EV analysis. Lastly, we demonstrate that the colloidal matrix of the biofluid in which EVs reside impacts their buoyant density, size and/or refractive index (RI), which may have consequences for down‐stream EV analysis and EV biomarker profiling.
Ultrasonic treatment as a modern technique to facilitate the extraction of phenolic compounds from organic sunflower seed cakes
Authors: Ali Mostafa , Khalil Mahmoud , Badawy Waleed Z. , Hellwig Michael 
Published: November 2023

AbstractBACKGROUNDThree different organic sunflower seed cakes, produced from seeds differing in the content of their hulls, were extracted by two different extraction methods – conventional extraction (CE) and ultrasound‐assisted extraction (UAE). The total phenolic compound (TPC) content of the extracts was evaluated using Folin–Ciocâlteu reagent (FCR) and high‐performance liquid chromatography (HPLC). The antioxidant capacity of extracts was evaluated with the Trolox equivalent antioxidant capacity (TEAC) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assays.RESULTSThe results showed that both extracts displayed high TPC content and antioxidant capacity. The UAE method showed significantly higher TPC content and antioxidant capacity values than CE. Individual phenolic compounds such as chlorogenic acid (CGA) isomers (3‐, 4‐ and 5‐O‐caffeoylquinic acids), di‐CGA isomers, and feruloylquinic and coumaroylquinic acids were identified according to their exact masses by HPLC coupled to time‐of‐flight mass spectrometry.CONCLUSIONThe results revealed that the UAE method could be used effectively to facilitate the extraction of phenolic compounds from sunflower seed cake. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Humidity‐Induced Reversible Crystallization of Laser‐Printing Perovskite Quantum Dots in Glass
Authors: Xiao Han , Lin Jidong , Chen Ronghua , Pang Tao , Huang Ping , Yu Yunlong , Zhuang Bin , Ye Qingying , Zhang Ruidan , Chen Daqin 
Published: November 2023

AbstractThe complex and high‐precision patterning of perovskite quantum dots (PeQDs) is of vital importance for exploring their new functionalities and device applications. In this work, a strategy based on the combination femtosecond (fs) laser‐irradiation and humidity‐control is reported to construct patterns of cyan CsPb(Cl/Br)3 PeQDs in a transparent glass medium. Benefiting from their ionic crystal feature and low formation energy, CsPb(Cl/Br)3 PeQDs can be locally crystallized and decomposed via fs laser irradiation without further heat‐treatment. More notably, it is found that a water molecule is able to affect the growth of CsPb(Cl/Br)3 PeQDs in glass. By modulation of relative humidity in air, the selectively decomposed perovskite structure is spontaneously regenerated, and the highly emissive CsPb(Cl/Br)3 PeQDs can be in situ manufactured in the confined glass region. This allows for reversible luminescence from the same patterns of laser printing‐erasing‐recovering, and the process can be repeated for multiple cycles without destruction of optical performance and robustness. The results provide a flexible method to develop new encryption/decryption technology for information security and anti‐counterfeiting.
Clinical Characteristics and Outcomes in Young‐Onset Multiple System Atrophy
Authors: Badihian Negin , Savica Rodolfo , Adler Charles H. , Wszolek Zbigniew K. , Jackson Lauren M. , Benarroch Eduardo E. , Sandroni Paola , Low Phillip A. , Singer Wolfgang , Coon Elizabeth A. 
Published: November 2023

AbstractBackgroundYoung‐onset multiple system atrophy (YOMSA) is defined as the onset of multiple system atrophy (MSA) before the age of 40 years old. YOMSA is rare and there is much uncertainty of the phenotype and natural history in patients with YOMSA.ObjectiveThe objective is to evaluate the characteristics and disease course of patients with YOMSA.MethodsWe retrospectively reviewed medical records of patients with MSA who were evaluated at all Mayo Clinic sites from 1998 to 2021. We identified patients with YOMSA and evaluated clinical characteristics, autonomic function testing results, and disease course.ResultsOf 1496 patients with a diagnosis of clinically probable or clinically established MSA, 20 patients had YOMSA. The median age of onset was 39.1 (interquartile range [IQR] = 37.1, 40.1) years; 13 patients (65%) were male. MSA‐parkinsonism was the most common subtype (65%). The median duration of symptom onset to YOMSA diagnosis was 4.9 (IQR = 3.7, 9) years. At the time of medical record review, 17 patients were deceased with a median survival of 8.3 (IQR = 7, 10.9) years. Univariate analysis showed that initial onset of autonomic failure predicted unfavorable survival (hazard ratio = 2.89, P = 0.04) compared to those who presented with motor impairment only at onset. At the time of YOMSA diagnosis, composite autonomic severity score was available in 19 patients with a median of 5 (IQR = 4, 6.5).ConclusionsYOMSA resembles MSA in most aspects including phenotype and prognosis, although the diagnosis is usually delayed. The presence of autonomic failure at symptom onset may be a poor predictor for survival.
Understanding the role of demand and supply integration in achieving retail supply chain agility: An information technology capability perspective
Authors: Bai Bingfeng 
Published: November 2023

AbstractWith the popularity of e‐commerce business, the evolution of information technology (IT) has played an important role in the evolution of global retail industry over the past two decades. Although the existing supply chain theories have discussed the effects of demand management on supply chain; however, there is a lack of in‐depth theoretical discussions among demand and supply integration (DSI) and supply chain agility from an IT capability view. The purpose of this study is to explore the role of DSI in achieving retail supply chain agility. Based on the information processing theory, this study takes JD.com and Alibaba, China's largest retailers, as business cases to conduct empirical investigations. We offer semi‐structured interviews with senior executives from IT, operations, and marketing department, and depict the coding process of survey data through a multi‐disciplinary literature review, grounded theory, and case study method. For retail firms, this study opens the black box of the antecedent research of supply chain agility by information processing theory, and puts forward some practical inspirations about retail IT capability under the COVID‐19 epidemic era.
Top management team stability and corporate default risk: The moderating effects of industry competition and strategic deviance
Authors: Liao Jia , Zhan Yun , Yuan Yu 
Published: November 2023

AbstractThis study takes Chinese A‐share listed firms from 2007 to 2020 as samples to examine the impact of top management team (TMT) stability on corporate default risk. The research findings reveal that TMT stability significantly mitigates corporate default risk. Furthermore, industry competition significantly strengthens the inhibitory effect of TMT stability on corporate default risk, while strategic deviance notably weakens this inhibitory effect. Heterogeneity analysis results indicate that the inhibitory effect of TMT stability on default risk is more pronounced for non‐state‐owned enterprises, firms situated in regions with higher levels of social trust, and during periods of elevated economic policy uncertainty.
Recent advances in TiO2 nanotube layers – A mini review of the latest developments in nanotube preparation and applications in photocatalysis and microwave sensing
Authors: Sopha Hanna , Alijani Mahnaz , Sepúlveda Marcela , Macak Jan M. 
Published: November 2023

AbstractSelf‐organized anodic TiO2 nanotube (TNT) layers prepared by anodization of Ti substrates have attracted great interest within the last 20 years, due to their unique properties and low‐cost synthesis. This mini review article aims to shortly summarize the most recent developments in the TNT layer synthesis and applications. It presents the synthesis of high aspect ratio (HAR) TNT layers in a short time by accelerating the TNT layer growth rates in lactic acid containing electrolytes. Furthermore, the etching of TNT layers towards TNT bundles of homogeneous size and single tube powders is discussed, as well as the possibility to grow TNT layers on non‐planar Ti substrates, which cannot be directly connected to the potentiostat (e.g., Ti spheres or 3D Ti meshes). As a relatively new application, the employment of TNT layers in microwave resonator sensors is introduced. Last, but not least, approaches of upscaling the TNT layer size from the laboratory scale towards significantly larger scale are outlined and reviewed.
Optimizing two‐variable gamma accelerated degradation tests with a semi‐analytical approach
Authors: Tung Hung‐Ping 
Published: November 2023

AbstractIn this paper, we provide a semi‐analytical approach to determine the optimal designs for two‐variable gamma accelerated degradation tests under three criteria: ‐optimality, ‐optimality, and ‐optimality. We first use general equivalence theorem to prove that the optimal approximate designs only allocate test units at the four vertices of a rectangular design region, and the corresponding optimal proportion of total number of measurements at each stress level is derived. Next, we apply the concept of prescribed accuracy level and total experimental cost to further determine optimal integer designs. More specifically, a numerical approach is used to resolve the number of test units and number of measurements at each stress level. Finally, an example is presented to illustrate the proposed procedure and compare the efficiency of optimal designs under three optimal criteria.
Numerical methods for rectangular multiparameter eigenvalue problems, with applications to finding optimal ARMA and LTI models
Authors: Hochstenbach Michiel E. , Košir Tomaž , Plestenjak Bor 
Published: November 2023

AbstractStandard multiparameter eigenvalue problems (MEPs) are systems of linear ‐parameter square matrix pencils. Recently, a new form of multiparameter eigenvalue problems has emerged: a rectangular MEP (RMEP) with only one multivariate rectangular matrix pencil, where we are looking for combinations of the parameters for which the rank of the pencil is not full. Applications include finding the optimal least squares autoregressive moving average (ARMA) model and the optimal least squares realization of autonomous linear time‐invariant (LTI) dynamical system. For linear and polynomial RMEPs, we give the number of solutions and show how these problems can be solved numerically by a transformation into a standard MEP. For the transformation we provide new linearizations for quadratic multivariate matrix polynomials with a specific structure of monomials and consider mixed systems of rectangular and square multivariate matrix polynomials. This numerical approach seems computationally considerably more attractive than the block Macaulay method, the only other currently available numerical method for polynomial RMEPs.
Bio‐inspired metal ion coordination cross‐linking synergistic strategy to enhance the interfacial properties of carbon fiber composites
Authors: Quan Guipeng , Wu Yunhuan , Zhang Yuxin , Xiao Linghan , Liu Yujing 
Published: November 2023

AbstractThe application of carbon fiber (CF) in carbon fiber composites has faced limitations due to its surface chemical inertness. To overcome this challenge, this study draws inspiration from metal ion‐enhancing exquisite hierarchical and multiphase structures observed in biological materials. The research proposes a novel approach to enhance the interfacial bonding of CF/Epoxy (E‐51) composites by utilizing tannic acid (TA), carboxylated cellulose nanocrystals (CNCs), Fe3+ ions, and polyvinyl alcohol (PVA). This approach aims to create hydrogen bonding and metal synergistic networks on the surface of CFs through metal ion (Mn+) coordination cross‐linking synergistic (MCCS) interactions. Implementing MCCS strategy resulted in significant improvements in the mechanical properties of the hybrid reinforcements compared to untreated CF composites. The flexural strength, flexural modulus, interlaminar shear strength, and interfacial shear strength experienced respective increase of 50.9%, 72.8% 59.4%, and 61.9%. Moreover, the damping properties of the composites exhibited significant improvements. These positive outcomes can be attributed to the formation of chelation and dense hydrogen bonding networks between TA, Fe3+, CNC, and PVA. Furthermore, CNC and PVA formed cross‐linked nanolayers that effectively deflected cracks and facilitated high energy consumption at the interface. This proposed approach provides a sustainable, environmentally friendly, and efficient method for surface modification in the preparation of high‐performance fiber composites.Highlights
Metal ion (Mn+) coordination cross‐linking synergistic strategy is proposed.
Tannins/Fe3+/CNCs/PVA form multiphase nanolayers.
Metal ion coordination cross‐linking enhances delicate multiphase structures.
The prepared carbon fiber composites exhibit excellent properties.
The as‐prepared carbon fiber composite has promising applications.
Plastically deformable polyethylene with excellent transparency and stress whitening resistance properties fabricated by constructing massive chain entanglement
Authors: Wu Buyong , Xia Bingqi , Du Wenhao , Zhou Yingguo 
Published: November 2023

AbstractStress whitening is one of the most prominent macroscopic defects for polyethylene (PE), which greatly affects the appearance and quality of its commodity. In order to eliminate the stress whitening defects of PE, ultrahigh molecular weight polyethylene (UHMWPE) was blended with PE to fabricated PE/UHMWPE, and the enhanced intermolecular entanglement and stretchability was achieved, which greatly suppressed and impeded the occurrence of heterogeneous plastic deformation and fibrillar bundle structure during applying tensile stress, resulting in the sharply deceased of the nanoscale cavities defects for the sample. And thus, the elimination of stress whitening defects and high‐light transmittance in the visible region with excellent optical transparency performance were successfully achieved for PE/UHMWPE. Moreover, introduction of UHMWPE chains significantly improved the orientation degree and formed a dense oriented crystalline network with fine lamellae for the sample, which highly enhanced the mechanical strength of PE/UHMWPE after applying stress. This work provided a new strategy for developing stress whitening eliminating polyolefin materials with high performance, which was of great significance for sustainable development and environmental friendliness.
Computational prediction of the properties of bis(ethynylthienyl)dialcoxynaphthalene‐based conjugated polymers for organic solar cell applications
Authors: Camarada María B. , Angel Felipe A. , Jessop Ignacio A. 
Published: November 2023

AbstractA series of homo‐ (P0) and copolymers (P1‐P5) based on the electron‐donor building‐block 2,2′‐(2,3‐bis(2‐ethylhexyloxy)naphthalene‐1,4‐diyl)bis(ethyne‐2,1‐diyl)dithiophene (1,4‐NET) including ethynyl linkers aiming to promote coplanarity were designed, and their properties predicted using theoretical methodologies to evaluate their potential in organic solar cell applications. The geometries, FMO levels, energy bandgaps, and absorption spectra of trimer models were determined using time‐dependent density functional theory, while their photovoltaic and charge‐transport properties were estimated by the Scharber's model and semiclassical Marcus theory, respectively. Compared to high‐performance conjugated polymers (CPs), such as PTB7‐Th or PM6, and similar systems based on the 1D‐BDT unit, the HOMO and LUMO levels of P0‐P5 tend to be higher. In addition, the new CPs have complementary absorptions with narrow‐bandgap acceptors, such as ITIC and Y6, and adequate matches between their HOMO and LUMO levels. Although the simulated photovoltaic and charge‐transport properties could be overestimated, the best candidate to be synthesized and tested in organic solar cells is P5 due to its suitable and well‐balanced properties, demonstrating the positive effect of incorporating ethynyl bridges to improve the optoelectronic properties of CPs.