bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propositive follow‐up: Long‐term immune responses to the 4CMenB and MenACWY vaccines in people living with HIV
Authors: San Francisco Ramos Alberto , Isitt Catherine , Athaide Shehnaz , Ladhani Shamez N. , Andrews Nicholas J. , Townsend‐Payne Kelly , Holland Ann , Louth Jennifer , Borrow Ray , Heath Paul T. , Cosgrove Catherine A. 
Published: November 2023

AbstractBackgroundPeople living with HIV have an increased risk of meningococcal disease. The Propositive trial evaluated co‐administration of two doses of a four‐component recombinant protein‐based MenB vaccine (4CMenB) and a quadrivalent conjugate polysaccharide MenACWY vaccine (MenACWY‐CRM197) given 1 month apart in people with HIV. The follow‐up trial assessed the immunogenicity of these vaccines at 1.5 and 2.5 years after primary vaccination.MethodsParticipants who completed the parent Propositive trial were invited to the follow‐up study. Immunogenicity analysis was performed at 18 and 30 months after primary vaccination. Primary outcome measures were serum bactericidal antibody (SBA) geometric mean titres (GMTs) against three MenB reference strains and the proportion of participants maintaining a protective SBA titre of ≥4 at 18 and 30 months. Secondary outcome measures were SBA GMTs against MenA, C, W, and Y serogroups and the proportion of participants maintaining a protective SBA titre of ≥8 at 18 and 30 months. The trial is registered with Clinicaltrials.gov (NCT042394300).ResultsA total of 40 participants aged 22–47 years were enrolled. Geometric mean titres waned by 18 and 30 months but remained higher than pre‐vaccination for all MenB strains and MenA, C, W, and Y. In total, 75%–85% of participants retained protective SBA titres by 30 months against individual MenB strains, whereas 68.8% of patients retained protective antibody titres against all three MenB strains. Antibodies against MenC waned more rapidly than did those against MenA, W, and Y. The proportion of participants with protective titres against MenC at 30 months was also lower (46.9%) than that with protective titres against MenA (87.5%), W (78.1%), and Y (87.5%).ConclusionsImmune responses against MenB in our cohort of people living with HIV at 2.5 years of follow‐up were reassuring, with 68.8% of participants retaining protection against all three reference strains. However, responses against MenC were lower than those against MenA, W, and Y serogroups.
Financial stressors and alternative financial service use: Extending the ABC‐X model of family stress
Authors: Fan Lu , Green Leslie E. , Park Narang 
Published: November 2023

AbstractThie study's purpose was to examine factors associated with alternative financial service (AFS) use among US consumers. The conceptual framework for this study was developed from the ABC‐X model of family stress with the purpose of identifying the interrelationships among financial stressors, economic hardship, negative credit experiences, and the use of AFS. Using the U.S. National Financial Well‐Being Survey and the structural equation modeling method, the results showed that financial stressor was not directly related to AFS use but were through two indirect routes: the financial stressor was positively linked to negative credit experience and then to AFS use; the financial stressor was positively linked to economic hardship, to negative credit experience, and then to AFS use. Economic hardship was positively associated with consumers' negative credit experiences. Negative credit experience was positively associated with the use of alternative financial services. The findings provide theoretical and practical implications.
Nosocomial COVID‐19 infection in the era of vaccination and antiviral therapy
Authors: McNeil Thomas , Zhang Frank , Moffatt Samuel , Emeto Theophilus I. , Tucker Emily 
Published: November 2023

AbstractBackground and AimsCoronavirus disease 2019 (COVID‐19) vaccination and antiviral therapies have altered the course of the COVID‐19 pandemic through mitigating severe illness and death. However, immunocompromised, elderly and multimorbid patients remain at risk of poor outcomes and are overrepresented in hospital populations. The aim of this study was to describe the characteristics and outcomes of patients with nosocomial COVID‐19 infection.MethodsThis was a retrospective, observational study of patients who acquired COVID‐19 after 7 days of hospital admission within the Southern Adelaide Local Health Network (SALHN) in South Australia between 1 June 2022 and 30 November 2022. Data were ascertained from the electronic medical record and the South Australian registry of births, deaths and marriages.ResultsOf 1084 COVID‐19 inpatient cases managed in SALHN, 295 (27%) were nosocomial, with 215 included in the study. The median age of patients was 80 years (interquartile range [IQR], 68–88 years), the median Charlson Comorbidity Index score was 5 (IQR, 4–7) and 6% were immunocompromised. Most nosocomial COVID‐19 infections were of mild severity (81%). The 30‐day all‐cause mortality rate following COVID‐19 infection was 6%, and, in most cases, a cause of death other than COVID‐19 was recorded on the death certificate.ConclusionThe majority of cases of nosocomial COVID‐19 infection were mild, with a lower mortality rate than in earlier studies. This finding is likely attributable to immunity through vaccination and prior infection, early antiviral therapy and attenuated severity of the Omicron variant. The high proportion of nosocomial infections supports ongoing infection control measures.
LRP4 mutations, dental anomalies, and oral exostoses
Authors: Kantaputra Piranit , Panichkul Weena , Sillapasorn Parisri , Adisornkanj Ploy , Kitsadayurach Panita , Kaewgaya Massupa , Intachai Worrachet , Olsen Bjorn , Ngamphiw Chumpol , Leethanakul Chidchanok , Jatooratthawichot Peeranat , Ketudat Cairns James R. , Tongsima Sissades 
Published: November 2023

AbstractBackgroundIn order to generate a normal set of teeth, fine‐tuning of Wnt/β‐catenin signaling is required, in which WNT ligands bind to their inhibitors or WNT inhibitors bind to their co‐receptors. Lrp4 regulates the number of teeth and their morphology by modulating Wnt/β‐catenin signaling as a Wnt/β‐catenin activator or inhibitor, depending on its interactions with the partner proteins, such as Sostdc1 and Dkk1.AimTo investigate genetic etiologies of dental anomalies involving LRP4 in a Thai cohort of 250 children and adults with dental anomalies.DesignOral and radiographic examinations and whole exome sequencing were performed for every patient.ResultsTwo novel (p.Leu1356Arg and p.Ala1702Gly) and three recurrent (p.Arg263His, p.Gly1314Ser, and p.Asn1385Ser) rare variants in low‐density lipoprotein receptor‐related protein 4 (LRP4: MIM 604270) were identified in 11 patients. Oral exostoses were observed in five patients.ConclusionAntagonism of Bmp signaling by Sostdc1 requires the presence of Lrp4. Mice lacking Lrp4 have been demonstrated to have alteration of Wnt–Bmp–Shh signaling and an abnormal number of incisors. Therefore, the LRP4 mutations found in our patients may disrupt Wnt–Bmp–Shh signaling, thereby resulting in dental anomalies and oral exostoses. Root maldevelopment in the patients suggests an important role of LRP4 in root morphogenesis.
Relationship among five categories of spiritual practices and five forms of well‐being: An empirical examination
Authors: Pawar Badrinarayan S. 
Published: November 2023

AbstractThis study notes that the existing literature suggests an important role for spirituality and religion in enhancing well‐being, and it hypothesizes the relationships of five categories of spiritual practices – religious practices, spiritual practices, existentialistic practices, humanistic practices and gratitude/awe‐related practices – with five forms of well‐being – physical well‐being, emotional well‐being, social well‐being, psychological well‐being and spiritual well‐being. In particular, this study develops an overall hypothesis specifying that the spiritual practices will be positively associated with five forms of well‐being and also develops four differential relationship hypotheses specifying that certain specific type of spiritual practices will have stronger associations with particular forms of well‐being. The results supported the overall hypothesis as the five spiritual practice categories collectively accounted for a statistically significant variance of 12% in physical well‐being, 14% in emotional well‐being, 29% in psychological well‐being, 28% in social well‐being and 40% in spiritual well‐being. The study results also provided varying levels of support for each of the remaining four differential relationship hypotheses, specifying that certain specific types of spiritual practices will have stronger associations with particular well‐being forms. The study makes significant theoretical contributions, provides directions for future research and has important implications for practice.
Synergic effect of photocatalysis and tribocatalysis for dye degradation by BaTiO3 ceramics
Authors: Gaur Akshay , Porwal Chirag , Chauhan Vishal Singh , Vaish Rahul 
Published: November 2023

AbstractTribocatalysis is one of the emerging processes for organic dye degradation application. The process uses mechanical energy as a source for breaking down organic pollutants present in water. The synergistic effect of two catalysis processes for eliminating organic pollutants, here in the present study photocatalysis an advanced oxidation process is integrated with the tribocatalysis process for enhancing the degradation efficiency of the tribocatalysis process by using BaTiO3 ceramic powder as a catalyst. The responsible factors for dye degradation via the tribocatalysis process such as surface roughness of the materials utilized, force applied, and energy band gap of the catalyst are also studied. The Methylene Blue dye's degradation was ∼39%, ∼60%, and ∼76 % through tribocatalysis, photocatalysis, and photo‐tribocatalysis respectively by using 400 mg BaTiO3 ceramic powder in 8 h. The synergistic effect of photocatalysis and tribocatalysis process showed enhanced degradation compared to individual processes.
Safety culture in maternity hospital: Perception of nurse‐midwives
Authors: Brás Cláudia Patrícia da Costa , Figueiredo Maria do Céu Aguiar Barbieri de , Ferreira Manuela Maria Conceição 
Published: November 2023

AbstractAimTo explore nurse‐midwives' perceptions of safety culture in maternity hospitals.DesignA descriptive phenomenological study was conducted using focus groups and reported following the Consolidated Criteria for Reporting Qualitative Research.MethodsData were obtained through two online focus group sessions in June 2022 with 13 nurse‐midwives from two maternity hospitals in the central region of Portugal. The first focus group comprised 6 nurse‐midwives, and the second comprised 7 nurse‐midwives. Qualitative data were analysed using content analysis.FindingsTwo main themes emerged from the data: (i) barriers to promoting a safety culture; (ii) safety culture promotion strategies. The first theme is supported by four categories: ineffective communication, unproductive management, instability in teams and the problem of errors in care delivery. The second theme is supported by two categories: managers' commitment to safety and the promotion of effective communication.ConclusionThe study results show that the safety culture in maternity hospitals is compromised by ineffective communication, team instability, insufficient allocation of nurse‐midwives, a prevailing punitive culture and underreporting of adverse events. These highlight the need for managers to commit to providing better working conditions, encourage training with the development of a fairer safety culture and encourage reporting and learning from mistakes. There is also a need to invest in team leaders who allow better conflict management and optimization of communication skills is essential.ImpactDisseminating these results will provide relevance to the safety culture problem, allowing greater awareness of nurse‐midwives and managers about vulnerable areas, and lead to the implementation of effective changes for safe maternal and neonatal care.Patient or Public ContributionThere was no patient or public contribution as the study only concerned service providers, that is, nurse‐midwives themselves.
METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy
Authors: Wang Fangfang , Bai Juan , Zhang Xin , Wang Dali , Zhang Xin , Xue Jingwen , Chen Haoyang , Wang Shuxiang , Chi Baojin , Li Jing , Ma Xiaoru 
Published: November 2023

ABSTRACTAimsThis research aimed to investigate the specific mechanism of methyltransferase like 3 (METTL3) in the progression of diabetic kidney disease (DKD).Materials and MethodsThe model of diabetic kidney disease was established with HK‐2 cells and mice in vitro and in vivo. The N6 methyladenosine (m6A) contents in the cells and tissues were detected with a commercial kit and the m6A levels of PTEN induced putative kinase 1 (PINK2) were detected with a MeRIP kit. The mRNA and protein levels were determined with RT‐qPCR and western blot. The ROS, TNF‐α, and IL‐6 levels were assessed with ELISA. The cell proliferative ability was measured by a CCK‐8 assay and cell apoptosis was determined with TUNEL staining. The HE and Masson staining was performed to observe the renal morphology. The RIP assay was conducted to detect the interaction between METTL3/YTHDF2 and PINK1.ResultsThe m6A content and METTL3 levels were prominently elevated in diabetic kidney disease. METTL3 silencing promoted the cell growth and the expression of LC3 II, PINK1, and Parkin, while inhibiting the cell apoptosis and the expression of LC3 I and p62 in the high glucose (HG) stimulated HK‐2 cells. METTL3 silencing also decreased the ROS, TNF‐α, and IL‐6 levels in diabetic kidney disease. PINK1 silencing neutralized the function of sh‐METTL3 in the HG stimulated HK‐2 cells. The HE and Masson staining showed that METTL3 silencing alleviated the kidney injury induced by DKD. METTL3 silencing decreased the m6A levels of PINK1, while increased the mRNA levels of PINK1 which depended on YTHDF2.ConclusionsMETTL3 silencing could inhibit the progression of diabetic nephropathy in vivo and in vitro by regulating the m6A modification of PINK1, which depends on YTHDF2. Our research lays the theoretical foundation for the precise treatment of diabetic kidney disease and the development of targeted drugs in the future.
Ultrasound‐assisted chlorogenic acid‐grafted chitosan soaking of sea bass (Lateolabrax japonicus) fillets to reduce protein oxidation and maintain gel properties
Authors: Yang Xin , Lan Weiqing , Sun Xiaohong 
Published: November 2023

AbstractThe perishability of aquatic products is a challenge for the processing of aquatic products, so it is better to choose suitable preservatives to prevent the degradation of proteins and the fission of their gel properties. Thus, this study investigated the effects of ultrasound‐assisted chlorogenic acid grafted chitosan (GUA) soaking of sea bass (Lateolabrax japonicus) fillets on protein oxidation and gelation properties. The results showed that GUA could reduce the formation of protein carbonyls and maintain Ca2+‐ATPase activity. Intrinsic fluorescence intensity (IFI) and SDS‐PAGE results demonstrated that GUA stabilized the tertiary structure of protein and inhibited protein degradation. Interestingly, ultrasound attenuated the protein aggregation induced by the use of chitosan‐grafted‐chlorogenic acid (CS‐g‐CA), which has good particle size during storage. Meanwhile, GUA treatment endowed the gel with a dense network microstructure, increased water holding capacity (WHC), reduced water mobility, and improved MP gel color as well as textural properties.
Association of a calcium channel blocker and diuretic prescribing cascade with adverse events: A population‐based cohort study
Authors: Rochon Paula A. , Austin Peter C. , Normand Sharon‐Lise , Savage Rachel D. , Read Stephanie H. , McCarthy Lisa M. , Giannakeas Vasily , Wu Wei , Strauss Rachel , Wang Xuesong , Chen Simon , Gurwitz Jerry H. 
Published: November 2023

AbstractBackgroundPrescribing cascades occur when a drug adverse event is misinterpreted as a new medical condition and a second, potentially unnecessary drug, is prescribed to treat the adverse event. The population‐level consequences of prescribing cascades remain unknown.MethodsThis population‐based cohort study used linked health administrative databases in Ontario, Canada. The study included community‐dwelling adults, 66 years of age or older with hypertension and no history of heart failure (HF) or diuretic use in the prior year, newly dispensed a calcium channel blocker (CCB). Individuals subsequently dispensed a diuretic within 90 days of incident CCB dispensing were classified as the prescribing cascade group, and compared to those not dispensed a diuretic, classified as the non‐prescribing cascade group. Those with and without a prescribing cascade were matched one‐to‐one on the propensity score and sex. The primary outcome was a serious adverse event (SAE), which was the composite of emergency room visits and hospitalizations in the 90‐day follow‐up period. We estimated hazard ratios (HRs) with 95% confidence intervals (CI) for SAE using an Andersen–Gill recurrent events regression model.ResultsAmong 39,347 older adults with hypertension and no history of HF who were newly dispensed a CCB, 1881 (4.8%) had a new diuretic dispensed within 90 days after CCB initiation. Compared to the non‐prescribing cascade group, those in the prescribing cascade group had higher rates of SAEs (HR: 1.21, 95% CI: 1.02–1.43).ConclusionsThe CCB‐diuretic prescribing cascade was associated with an increased rate of SAEs, suggesting harm beyond prescribing a second drug therapy. Our study raises awareness of the downstream impact of the CCB‐diuretic prescribing cascade at a population level and provides an opportunity for clinicians who identify this prescribing cascade to review their patients' medications to determine if they can be optimized.
Preliminary content and construct validity of a new model to differentiate research skills from evidence‐based practice skills: Core, Evidence Application, Research (CEAR) Model
Authors: Jordan Raeanne , Watowicz Rosanna P. , King Carrie , Phillips Catherine , Obeid Rita , Hand Rosa K. 
Published: November 2023

AbstractBackgroundResearch is the scientific basis for the profession of dietetics, as it must be located and applied in evidence‐based practice (EBP). EBP is often presented as a foundational skill for research. CEAR – Core, Evidence Application, Research – is a newly proposed model that separates Research and Evidence Application skills into distinct domains, jointly supported by a set of Core skills, thus acknowledging that education and advancement in one domain neither requires nor precipitates education and advancement in the other. The goal was to investigate the content and construct validity of the new CEAR Model.MethodsA cross‐sectional online survey of randomly selected dietitians in the United States was used to collect CEAR domain scores, validated measures of research or EBP skills and self‐reported characteristics. Exploratory factor analysis, Cronbach's α and Pearson correlation between various tools and CEAR domains were used to assess validity and reliability. Analysis of variance (ANOVA) and multiple linear regression between CEAR domains and participant characteristics were used to assess convergent and divergent validity.ResultsOne hundred and fifty‐four responses with a valid CEAR score were received and led to a three‐factor solution, supporting the theorised differentiation of research from evidence application skills (content validity). Internal reliability for the CEAR Model overall and for each domain was high. The hypothesised correlations between existing research or EBP measurement tools and the relevant CEAR domains were found (construct validity). Known groups analysis demonstrated the expected differences in CEAR domain scores based on participant characteristics.ConclusionsThe CEAR Model demonstrates preliminary validity and internal reliability. It adds to the current literature by acknowledging the separateness of evidence application skills from research skills.
Comparison of anaesthesia‐related outcomes in patients monitored by newly recruited nurse anaesthetists and anaesthesiologists: An observational study
Authors: Cao Qinqin , Fan Chengjuan , Ren Xiaolei , Bai Shuling , Dong Hemin , Wei Min , Meng Haihong 
Published: November 2023

AbstractAimsTo compare anaesthesia‐related outcomes between patients monitored by newly recruited nurse anaesthetists and those monitored by newly recruited anaesthesiologists.DesignThis was a retrospective study.MethodsWe conducted a retrospective study that collected demographic information on newly recruited nurse anaesthetists and anaesthesiologists between 2017 and 2022 and recorded information on patients within 6 months of monitoring. Postoperative pain, emergency agitation, nausea, and vomiting were designated anaesthesia‐related outcomes. Propensity score matching was used to adjust for covariates. The study adhered to the STROBE guidelines.ResultsThe study's statistical analysis included 4483 patients monitored by 22 newly recruited nurse anaesthetists and 4959 patients monitored by 23 newly recruited anaesthesiologists. Compared with patients monitored by newly trained anaesthesiologists, the patients monitored by nurse anaesthetists were younger (42.07 ± 20.00 vs. 47.39 ± 18.45 years, p < 0.001) and had a lower body mass index (23.56 ± 4.46 vs. 24.19 ± 4.25, p < 0.001). Patients monitored by anaesthesiologists had a greater proportion of women (61.62% vs. 59.25%, p < 0.001), a high proportion of ASA III and ASA IV (17.1% vs. 8.88%, p < 0.001), and a longer mean surgery duration (78.65 ± 59.01 vs. 70.70 ± 60.65 min, p < 0.001). After propensity score matching was used to adjust for covariates, no statistically significant differences were found in the prevalence of postoperative pain, emergency agitation, or postoperative nausea and vomiting between the two groups (p < 0.05).ConclusionNurse anaesthetists monitoring alone during anaesthesia maintenance is feasible and safe. The two groups had no significant differences in the incidence of postoperative pain, emergency agitation, or postoperative nausea and vomiting.Relevance to Clinical PracticeThe shortage of anaesthesiologists leads to heavy work burden and high incidence of occupational burnout among anaesthesiologists. The study found that it was safe for nurse anaesthetists to perform anaesthetic monitoring alone in the operating room under the supervision of the attending anaesthesiologist and did reduce the burden of anaesthesiologists’ work. The results of the current study contribute to the expansion of occupational categories for nurse anaesthetists in countries where anaesthesiologists are in short supply. It provides new ideas for hospital administrators and policy‐makers to formulate medical and nursing service policies.