bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of implementation reporting in opioid stewardship literature
Authors: Pattullo Champika , Suckling Benita , Dace William , Donovan Peter , Hall Lisa 
Published: November 2023

Abstract
Background
The increased awareness of opioid-related harms has resulted in a proliferation of safety strategies and hospital-based quality improvement initiatives, often referred to as ‘opioid stewardship’ interventions. The effective translation of these interventions into more widespread practice relies on understanding and adapting important details of the implementation process. However, as with many healthcare quality improvement studies, the context, and details of the implementation are often absent from the published literature, limiting the scale and spread of practice.

Aim
To systematically review studies describing opioid stewardship interventions in acute hospital settings and assess the reporting of their implementation.

Method
A literature search of opioid stewardship interventions in MEDLINE/PubMed, EMBASE, Web of Science and the Cochrane Library from January 2000 to August 2020 was performed. We used Preferred Reporting Items for Systematic Reviews and Meta-analyses. Studies were screened initially for an evaluation of the intervention and subsequently for the inclusion of implementation reporting. The latter was coded using the four Normalisation Process Theory (NPT) domains.

Results
The database searches identified a total of 4031 publications, of which 372 underwent a full text review and 13 studies were included in the final analysis. The main reasons for exclusion during full-text review were insufficient details of the intervention (n = 90/354, 25%) or implementation (n = 215/354, 61%) to undergo an NPT analysis. When evaluating the potential for scale and spread of an intervention, all studies (n = 13) met the criteria for coherence, cognitive participation, and collective action, but only 3 reported on reflexive monitoring.

Conclusion
We identified only a small number of opioid stewardship studies that described the implementation processes of the reported interventions. This may be a barrier to effective translation of interventions into broader practice, limiting the potential for impact and benefit to patients and the wider community. Future studies of opioid stewardship interventions should consider using implementation science e.g., NPT across all aspects of knowledge translation and reporting.
Terra Nova
Authors: Bouchard Jack 
Published: November 2023

RésuméAu début du xvie siècle, les marins européens établirent une pêcherie commerciale et un site d’occupation permanent dans l’Atlantique du Nord-Ouest. Comment nommer ce lieu ? Cet article défend l’idée que ces marins développèrent leur propre conception de l’espace par le prisme de la création de la pêcherie – une conception qui était le reflet des cartes mentales qu’ils avaient développées à travers la pratique du travail de la pêche. Il soutient qu’au lieu d’utiliser une terminologie contemporaine comme Newfoundland, les spécialistes devraient au contraire s’emparer de cette grille de lecture géographique pour traiter des premières années de la pêcherie et de la colonisation. Des marins de toute l’Europe ont utilisé l’expression Terra Nova et ses variantes afin de désigner un espace fluctuant, vaste et aqueux dans l’Atlantique du Nord-Ouest. Son usage s’est montré cohérent dans le temps et l’espace, et liait la géographie à la pratique de la pêche. Cet article restitue les cartes mentales du xvie siècle, retrace l’origine et la diffusion du syntagme Terra Nova et montre en quoi il diffère des géographies et des désignations des cartographes. Dans sa dernière partie, il réfléchit à la relation entre le travail, la mer et l’espace, et à la manière dont celle-ci a contribué à l’usage de Terra Nova. Ce faisant, il offre le moyen de retrouver les cartes mentales oubliées et de démontrer la malléabilité des géographies maritime au début de l’histoire de l’expansion européenne dans le bassin atlantique.
Specifications and control of spatial frequency errors of components in two-beam laser static holographic exposure for pulse compression grating fabrication
Authors: Hu Chen , Wan Songlin , Jiang Guochang , Gu Haojin , Zhang Yibin , Jin Yunxia , Liu Shijie , Zhao Chengqiang , Cao Hongchao , Wei Chaoyang , Shao Jianda 
Published: November 2023

AbstractThe large-aperture pulse compression grating (PCG) is a critical component in generating an ultra-high-intensity, ultra-short-pulse laser; however, the size of the PCG manufactured by transmission holographic exposure is limited to large-scale high-quality materials. The reflective method is a potential way for solving the size limitation, but there is still no successful precedent due to the lack of scientific specifications and advanced processing technology of exposure mirrors. In this paper, an analytical model is developed to clarify the specifications of components, and advanced processing technology is adopted to control the spatial frequency errors. Hereafter, we have successfully fabricated a multilayer dielectric grating of 200 mm × 150 mm by using an off-axis reflective exposure system with Φ300 mm. This demonstration proves that PCGs can be manufactured by using the reflection holographic exposure method and shows the potential for manufacturing the meter-level gratings used in 100 petawatt class high-power lasers.
Macauba (Acrocomia aculeata) pulp oil has the potential to enhance the intestinal barrier morphology, goblet cell proliferation and gut microbiota composition in mice fed a high-fat diet
Authors: Sant’ Ana Cíntia Tomaz , Verediano Thaísa Agrizzi , Grancieri Mariana , Lopes Toledo Renata Celi , Costa Neuza Maria Brunoro , Martino Hércia Stampini Duarte , Barros Frederico Augusto Ribeiro de 
Published: November 2023

AbstractMacauba (Acrocomia aculeata) is a palm tree native from Brazil, whose pulp is rich in oil that has a high content of oleic acid and carotenoids. Macauba pulp oil can bring health benefits due to its bioactive compounds; however, its effects on gut health are unknown. Thus, the objective of this study was to evaluate the effect of macauba pulp oil on the intestinal health in mice fed a high-fat (HF) diet. Male C57BL1/6 mice were randomly divided into three groups (10 animals/group): control diet, HF diet and HF diet with 4 % of macauba pulp oil (HFM). Concentration of short-chain fatty acids (SCFA), faecal pH and histomorphometric analysis of the colon were performed. Content of colon samples was used on microbiome analysis using 16S rRNA amplicon sequencing. Animals from the HFM group had higher butyric acid content and goblet cells number, greater circular and longitudinal muscle layer and higher α-diversity compared with the HF group. Moreover, consumption of MPO reduced Desulfobacterota phylum, Ruminococcaceae, Oscillospiraceae, Prevotellaceae, Bifidobacteriaceae family, Faecalibacterium, Prevotella, Ruminococcus and Enterorhabdus genus. Therefore, macauba pulp oil was able to modulate the gut microbiota and enhance intestinal barrier morphology, showing preventive effects on gut dysbiosis in mice fed a HF diet.
Type synthesis and trajectory planning of 5-DOF redundantly actuated parallel robots with large output rotational angles for large workpieces
Authors: Jiang Bingshan , Huang Guanyu , Zhu Shiqiang , Fang Hairong , Tian Xinyu , Xie Anhuan , Zhang Lan , Zhao Pengyu , Gu Jianjun , Kong Lingyu 
Published: November 2023

AbstractAerospace represents the development of national science and technology. It is an important foundation for exploring space and an important guarantee for the construction of aerospace power. There are many large workpieces in the aerospace field. The box insulation layer of large workpieces is an important processing problem. A new thick processing equipment is proposed to process the box insulation layer of large workpieces. The thick processing equipment consists of the XYZ shaft long guide rail and five degrees of freedom (5-DOF) RAPA. The mechanical structure of the 5-DOF RAPA is a redundantly actuated parallel mechanism (RAPM). Meanwhile, this paper proposes a new method to design 5-DOF redundantly actuated parallel mechanisms (RAPMs) with large output rotational angles. Based on configuration evolution and Li group, two articulated moving platforms (AMPs) and four kinds of limbs are designed, and a series of 3T2R (T represents translation, R represents rotation) RAPMs and 2T3R RAPMs are synthesized. To verify the designed RAPMs with large angle, an example of RAPMs, 4UPS-{2UPR}-R is analyzed. To ensure that the RAPM has no mechanism vibration impact in movement, this paper represents the RAPM adopts a newly proposed trajectory planning method. The results show that the 4SPU-(2UPR)R mechanism possesses large angles and verifies the efficiency of the new proposed trajectory planning method in simplified trajectories. This work lays the foundation for processing the box insulation layer of large workpieces with straight lines and arcs paths.
Reproductive outcomes with delayed blastocyst development: the clinical value of day 7 euploid blastocysts in frozen embryo transfer cycles
Authors: Abdala Andrea , Elkhatib Ibrahim , Bayram Aşina , El-Damen Ahmed , Melado Laura , Nogueira Daniela , Lawrenz Barbara , Fatemi Human M. 
Published: November 2023

SummaryEmbryos of optimal development reach blastocyst stage 116 ± 2 h after insemination. Usable D7 blastocysts represent nearly 5% of embryos in IVF with acceptable pregnancy and live birth rates, however data are still limited. Therefore, this study aimed to analyze the ongoing pregnancy rate (OPR) of D7 blastocysts in single euploid frozen embryo transfer (FET) cycles. An observational study was performed including 1527 FET cycles with blastocysts biopsied on D5 (N = 855), D6 (N = 636) and D7 (N = 36). Blastocysts were classified as good (AA/AB/BA), fair (BB) or poor (AC/BC/CC/CA/CB) (Gardner scoring). FETs were performed in natural cycles (NC) or hormone replacement therapy (HRT) cycles. Patient’s age differed significantly between D5, D6 and D7 blastocysts FET cycles (33.2 ± 5.6, 34.4 ± 5.3 and 35.9 ± 5.2, P < 0.001). OPRs were higher when D5 euploid blastocysts were transferred compared with D6 and D7 (56.0% vs. 45.3% and 11.1%, P < 0.001). Poor quality blastocysts were predominant in D7 blastocyst FET cycles (good quality: 35.4%, 27.2%, 5.6%; fair quality: 52.1%, 38.5%, 11.1%; poor quality: 12.5%, 34.3%, 83.3%, P < 0.001 for D5, D6 and D7 blastocysts; respectively). OPR was significantly reduced by D7 blastocyst FETs (OR = 0.23 [0.08;0.62], P = 0.004), patient’s BMI (OR = 0.96 [0.94;0.98], P < 0.001), HRT cycles (OR = 0.70 [0.56;0.88], P = 0.002) and poor quality blastocysts (OR = 0.33 [0.24;0.45], P < 0.001). OPR is significantly reduced with D7 compared with D5/D6 euploid blastocysts in FET cycles. The older the patient, the more likely they are to have an FET cycle with blastocysts biopsied on D7, therefore culturing embryos until D7 can be a strategy to increase OPR outcomes in patients ≥38 years.
A Community‐Based Approach to Climate Science Communication: Results From a Pilot Climate Extension Program
Authors: Clark Suzanna , Roop Heidi A. , Gonzales Katerina R. , Mohr Caryn , Dybsetter Anne , Kingery Linda 
Published: November 2023

AbstractWhile the majority of adults across the United States report that they believe that global warming is happening, far fewer report discussing global warming (Howe et al., 2015, https://doi.org/10.1038/nclimate2583; Marlon et al., 2022, https://climatecommunication.yale.edu/visualizations‐data/ycom‐us/). One way to inspire further climate action and engagement is to increase individuals' capacity to confidently and effectively discuss climate change. Climate communication science highlights that such communication is most effective when it is anecdotal, narrative, tailored to the audience, and place‐based. To generate climate conversations and inspire action in a variety of communities, partners at the University of Minnesota Extension piloted a program to train community members from across the state of Minnesota in effective climate communication through a series of instructional workshops, coaching, and participant‐led communication activities. Following the training portion of the program, participants identified and hosted their own climate‐related communication activities in their communities. These “climate conversations” took place across Minnesota and included community events, dialogue with elected leaders, and conversations stimulated through literature, among other activities. In their communities, program participants sparked conversations, initiated long‐term climate action efforts, and improved their sense of efficacy in response to climate change. Participants also reported that they improved their climate conversation skills, increased their local climate knowledge, established a support network with fellow participants, had reduced anxiety around communicating, and increased their confidence in being able to communicate about climate change in their communities. This pilot program provides a framework for future cohort‐ and community‐based climate communication programs in the state and beyond.
Development of the SURface Fast Emissivity Model for Ocean (SURFEM‐Ocean) Based on the PARMIO Radiative Transfer Model
Authors: Kilic Lise , Prigent Catherine , Jimenez Carlos , Turner Emma , Hocking James , English Stephen , Meissner Thomas , Dinnat Emmanuel 
Published: November 2023

AbstractA Passive and Active Reference Microwave to Infrared Ocean (PARMIO) physical radiative transfer model has been selected by an international team of experts to be used as a community ocean surface emissivity model. A fast version of this physical community model is developed within the framework of European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) Numerical Weather Prediction Satellite Application Facilities visiting scientist programme: the SURface Fast Emissivity Model for Ocean (SURFEM‐Ocean), for implementation in the Radiative Transfer code for TOVS (RTTOV) as an alternative/replacement of the well‐known FAST microwave Emissivity Model (FASTEM). First, the configuration of the PARMIO model is adapted to microwave frequencies from 500 MHz to 700 GHz, and issues observed in the preliminary studies with cold sea surface temperatures (SST) and high ocean wind speeds (OWS) are corrected. Second, an artificial neural network method is used to reproduce the results of the PARMIO model much faster. The computation of the analytical Jacobians is also implemented. Finally, SURFEM‐Ocean results are compared with satellite observations and other ocean emissivity models. SURFEM‐Ocean extends the capability of FASTEM. It computes emissivities from 500 MHz to 700 GHz, for all incidence angles, for the fourth Stokes polarizations, for OWS from 0 to 50 m/s, SST from −2 to 30°C, sea surface salinity from 0 to 40 psu, and for all wind directions.
Homogenization of Porous Thin Layers With Internal Stratification for the Estimation of Seismic Reflection Coefficients
Authors: Sotelo Edith , Barbosa Nicolás D. , Solazzi Santiago G. , Rubino J. Germán , Favino Marco , Holliger Klaus 
Published: November 2023

AbstractStratified thin layers often present a prominent mechanical contrast with regard to the embedding background and, hence, are important targets for seismic reflection studies. An efficient way to study the reflectivity response of these thin layers is to employ their homogenized viscoelastic equivalents. We aim to homogenize a simple, yet realistic, thin‐layer model, which is composed of a finite non‐periodic sequence of homogeneous porous strata embedded in a background deemed impermeable at the seismic frequencies. The overarching objective is to reproduce the reflectivity response of such stratified thin layers. However, the estimation of the equivalent moduli is inherently affected by the boundary conditions (BC) associated with the embedding background. Therefore, classical homogenization procedures, which assume the existence of a periodic structure, are not readily applicable. We, therefore, propose a novel homogenization procedure that incorporates naturally the appropriate BC. To this end, we consider a sample that includes both a part of the background and a section of the thin layer, to which we apply classical oscillatory relaxation tests. However, we estimate the average of stress and strain components only over the thin layer section of interest. To test the accuracy of the method, we consider a sandstone composed of two strata saturated with different fluids embedded in impermeable half‐spaces. After estimating the corresponding equivalent moduli, we compare the resulting P‐wave reflectivities with those obtained using the original model. Our results show that the inferred viscoelastic equivalent closely reproduces the reflectivities of the stratified thin layer in the seismic frequency range.
Coevolution of Rock Slope Instability Damage and Resonance Frequencies From Distinct‐Element Modeling
Authors: Jensen E. K. , Moore J. R. 
Published: November 2023

AbstractAmbient vibration measurements can detect resonance frequency changes related to rock slope instability damage or boundary condition changes during progressive failure. However, the impact of slope kinematics on resonance changes and the expected form and sensitivity of frequency evolution during destabilization require clarification to improve the implementation of this technique across diverse settings. Since instrumented rock slope failures are rare, numerical modeling is needed to study the anticipated spectral response from in situ monitoring. We used 2D distinct‐element modeling to evaluate the sensitivity and evolution of rock slope resonance behavior for slab toppling, flexural toppling, and planar sliding instabilities during progressive failure. Model simulations revealed that fundamental resonance frequency decreases between 20% and 60% with changes correlated with increasing length of open joints. Changes to higher‐order frequencies associated with landslide sub‐volumes were also detectable for cases with multiple fracture networks. Resonance behavior was most pronounced for failures dominated by steeply dipping open tension cracks, that is, flexural and slab toppling. Additionally, amplification patterns across the slope varied for the flexural toppling and sliding cases, providing potential new information with which to characterize landslide failure mechanisms using ambient vibration array measurements. Our results demonstrate landslide characteristics well‐suited for in situ ambient resonance monitoring and provide new data describing the anticipated changes in resonance frequencies during progressive rock slope failure.
Forecasting Geomagnetic Storm Disturbances and Their Uncertainties Using Deep Learning
Authors: Conde D. , Castillo F. L. , Escobar C. , García C. , García J. E. , Sanz V. , Zaldívar B. , Curto J. J. , Marsal S. , Torta J. M. 
Published: November 2023

AbstractSevere space weather produced by disturbed conditions on the Sun results in harmful effects both for humans in space and in high‐latitude flights, and for technological systems such as spacecraft or communications. Also, geomagnetically induced currents (GICs) flowing on long ground‐based conductors, such as power networks, potentially threaten critical infrastructures on Earth. The first step in developing an alarm system against GICs is to forecast them. This is a challenging task given the highly non‐linear dependencies of the response of the magnetosphere to these perturbations. In the last few years, modern machine‐learning models have shown to be very good at predicting magnetic activity indices. However, such complex models are on the one hand difficult to tune, and on the other hand they are known to bring along potentially large prediction uncertainties which are generally difficult to estimate. In this work we aim at predicting the SYM‐H index characterizing geomagnetic storms multiple‐hour ahead, using public interplanetary magnetic field (IMF) data from the Sun‐Earth L1 Lagrange point and SYM‐H data. We implement a type of machine‐learning model called long short‐term memory (LSTM) network. Our scope is to estimate the prediction uncertainties coming from a deep‐learning model in the context of forecasting the SYM‐H index. These uncertainties will be essential to set reliable alarm thresholds. The resulting uncertainties turn out to be sizable at the critical stages of the geomagnetic storms. Our methodology includes as well an efficient optimization of important hyper‐parameters of the LSTM network and robustness tests.
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
Authors: Talukdar Priyanka Dey , Chatterji Urmi 
Published: November 2023

AbstractSpecific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the co-activators. Deregulation of these regulatory molecules is associated with cell state transitions, which in turn is accountable for diverse maladies, including developmental disorders, metabolic disorders, and most significantly, cancer. A decade back most transcription factors, the key enablers of disease development, were historically viewed as ‘undruggable’; however, in the intervening years, a wealth of literature validated that they can be targeted indirectly through transcriptional co-activators, their confederates in various physiological and molecular processes. These co-activators, along with transcription factors, have the ability to initiate and modulate transcription of diverse genes necessary for normal physiological functions, whereby, deregulation of such interactions may foster tissue-specific disease phenotype. Hence, it is essential to analyze how these co-activators modulate specific multilateral processes in coordination with other factors. The proposed review attempts to elaborate an in-depth account of the transcription co-activators, their involvement in transcription regulation, and context-specific contributions to pathophysiological conditions. This review also addresses an issue that has not been dealt with in a comprehensive manner and hopes to direct attention towards future research that will encompass patient-friendly therapeutic strategies, where drugs targeting co-activators will have enhanced benefits and reduced side effects. Additional insights into currently available therapeutic interventions and the associated constraints will eventually reveal multitudes of advanced therapeutic targets aiming for disease amelioration and good patient prognosis.