bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Polarized Cosmic Hand: IXPE Observations of PSR B1509−58/MSH 15−52
Authors: Romani Roger W. , Wong Josephine , Di Lalla Niccoló , Omodei Nicola , Xie Fei , Ng C.-Y. , Ferrazzoli Riccardo , Di Marco Alessandro , Bucciantini Niccoló , Pilia Maura , Slane Patrick , Weisskopf Martin C. , Johnston Simon , Burgay Marta , Wei Deng , Yang Yi-Jung , Zhang Shumeng , Antonelli Lucio A. , Bachetti Matteo , Baldini Luca , Baumgartner Wayne H. , Bellazzini Ronaldo , Bianchi Stefano , Bongiorno Stephen D. , Bonino Raffaella , Brez Alessandro , Capitanio Fiamma , Castellano Simone , Cavazzuti Elisabetta , Chen Chien-Ting , Cibrario Nicoló , Ciprini Stefano , Costa Enrico , De Rosa Alessandra , Del Monte Ettore , Di Gesu Laura , Donnarumma Immacolata , Doroshenko Victor , Dovčiak Michal , Ehlert Steven R. , Enoto Teruaki , Evangelista Yuri , Fabiani Sergio , Garcia Javier A. , Gunji Shuichi , Hayashida Kiyoshi , Heyl Jeremy , Iwakiri Wataru , Liodakis Ioannis , Kaaret Philip , Karas Vladimir , Kim Dawoon E. , Kitaguchi Takao , Kolodziejczak Jeffery J. , Krawczynski Henric , La Monaca Fabio , Latronico Luca , Madejski Grzegorz , Maldera Simone , Manfreda Alberto , Marin Frédéric , Marinucci Andrea , Marscher Alan P. , Marshall Herman L. , Massaro Francesco , Matt Giorgio , Middei Riccardo , Mitsuishi Ikuyuki , Mizuno Tsunefumi , Muleri Fabio , Negro Michela , O’Dell Stephen L. , Oppedisano Chiara , Pacciani Luigi , Papitto Alessandro , Pavlov George G. , Perri Matteo , Pesce-Rollins Melissa , Petrucci Pierre-Olivier , Possenti Andrea , Poutanen Juri , Puccetti Simonetta , Ramsey Brian D. , Rankin John , Ratheesh Ajay , Roberts Oliver J. , Sgró Carmelo , Soffitta Paolo , Spandre Gloria , Swartz Douglas A. , Tamagawa Toru , Tavecchio Fabrizio , Taverna Roberto , Tawara Yuzuru , Tennant Allyn F. , Thomas Nicholas E. , Tombesi Francesco , Trois Alessio , Tsygankov Sergey , Turolla Roberto , Vink Jacco , Wu Kinwah , Zane Silvia 
Published: October 2023

Abstract
We describe IXPE polarization observations of the pulsar wind nebula (PWN) MSH 15−52, the “Cosmic Hand.” We find X-ray polarization across the PWN, with B-field vectors generally aligned with filamentary X-ray structures. High-significance polarization is seen in arcs surrounding the pulsar and toward the end of the “jet,” with polarization degree PD > 70%, thus approaching the maximum allowed synchrotron value. In contrast, the base of the jet has lower polarization, indicating a complex magnetic field at significant angle to the jet axis. We also detect significant polarization from PSR B1509−58 itself. Although only the central pulse phase bin of the pulse has high individual significance, flanking bins provide lower-significance detections and, in conjunction with the X-ray image and radio polarization, can be used to constrain rotating vector model solutions for the pulsar geometry.
Transiting Exoplanet Yields for the Roman Galactic Bulge Time Domain Survey Predicted from Pixel-level Simulations
Authors: Wilson Robert F. , Barclay Thomas , Powell Brian P. , Schlieder Joshua , Hedges Christina , Montet Benjamin T. , Quintana Elisa , Mcdonald Iain , Penny Matthew T. , Espinoza Néstor , Kerins Eamonn 
Published: October 2023

Abstract
The Nancy Grace Roman Space Telescope (Roman) is NASA’s next astrophysics flagship mission, expected to launch in late 2026. As one of Roman’s core community science surveys, the Galactic Bulge Time Domain Survey (GBTDS) will collect photometric and astrometric data for over 100 million stars in the Galactic bulge in order to search for microlensing planets. To assess the potential with which Roman can detect exoplanets via transit, we developed and conducted pixel-level simulations of transiting planets in the GBTDS. From these simulations, we predict that Roman will find between ∼60,000 and ∼200,000 transiting planets—over an order of magnitude more planets than are currently known. While the majority of these planets will be giants (R

p
> 4R
⊕) on close-in orbits (a < 0.3 au), the yield also includes between ∼7000 and ∼12,000 small planets (R

p
< 4R
⊕). The yield for small planets depends sensitively on the observing cadence and season duration, with variations on the order of ∼10%–20% for modest changes in either parameter, but is generally insensitive to the trade between surveyed area and cadence given constant slew/settle times. These predictions depend sensitively on the Milky Way’s metallicity distribution function, highlighting an opportunity to significantly advance our understanding of exoplanet demographics, in particular across stellar populations and Galactic environments.
Traversée du genre, traversée du fantasme
Authors: Hefez Serge 
Published: October 2023

La sexualité reste un terrain peu exploré des études sur la transidentité. Si sexe et genre recouvrent des données hétérogènes, il est difficile de ne pas entendre des questionnements qui s’entremêlent. L’auteur s’appuie sur ce que des jeunes en transition, en fluidité de genre, ou qui souhaitent échapper aux catégories homme/femme, homo/hétero, cis/trans disent de leurs pratiques sexuelles. Comment intervient la puissance d’agir de ces corps en transformation dans l’élaboration de nos théories ?
De l’effacement de soi à l’appropriation subjective
Authors: Ewanzo Lydia , Jung Johann 
Published: October 2023

Cet article explore la problématique de l’effacement de soi à l’adolescence et ses enjeux au regard du processus d’appropriation subjective à partir d’un cadre-dispositif original centré sur le « récit dessiné ». Le travail clinique engagé auprès d’une jeune adolescente aux prises avec une souffrance narcissique-identitaire nous conduit à repérer comment l’effacement de soi participe à la réorganisation des capacités réflexives et au rétablissement des conditions de subjectivation en appui sur la fonction miroir du médium et du thérapeute.
Dispositif « triple résonance » : accueillir le trauma
Authors: Hafhouf-Lacôte Hindi , Neyroud Julia 
Published: October 2023

À partir d’une clinique auprès d’adolescents en maison d’enfants à caractère social (MECS) qui confronte à la non-demande en même temps qu’à une modalité de lien aux prises avec la séduction narcissique, l’incestuel et la toute-puissance, nous interrogeons les modalités du dispositif qui permettraient d’engager un processus thérapeutique. À cet effet, nous proposons de définir le dispositif « en triple résonance » et d’illustrer, à partir de la situation d’un adolescent de quinze ans, ses potentiels effets et leviers.
Synthesis and biological evaluation of gallic acid esters as phagocyte oxidative burst inhibitors
Authors: Baheej M.A.A. , Haniffa H.M. , Siddiqui H. , Jabeen A. 
Published: October 2023

Several degenerative diseases, including cancer, are caused by oxidative stress, which is caused by the overproduction and accumulation of free radicals. The purpose of the study was to synthesize gallic acid (GA or 3,4,5-trihydroxybenzoic acid) esters and evaluate their anti-inflammatory potential through the inhibition of reactive oxygen species (ROS). The compounds methyl gallate (2), sec-butyl gallate (3), ethyl gallate (4), isopropyl gallate (5), 2-methoxyethyl gallate (6), 4-methoxybutyl gallate (7), 2-methylbutyl gallate (8) and pentan-3-yl gallate (9) were synthesized. 1H NMR, MS and IR data are reported for compounds 2-9, and 13C NMR data for compounds 2, 3, 5, and 6. The molecular formulae of compounds 3 and 7-9 were established by HREI-MS spectroscopic data. All the synthesized compounds were tested for their anti-inflammatory and cytotoxic activities by chemiluminescence and MTT cytotoxicity assay respectively. The results revealed the anti-inflammatory potential of compounds 2-8 with an IC50 range between (13.3 – 54.3 µM) as compared to the standard anti-inflammatory drug, Ibuprofen (IC50 = 54.3 ± 9.2 μM). The most potent inhibitors were found to be compound 3 (ROS IC50 = 15.0 ± 6.6 µM) and compound 7 (ROS IC50 = 13.3 ± 0.8 µM). All compounds were found to be non-cytotoxic in the NIH-3T3 fibroblast cell line. Compounds 3, 7- 9 were identified as new compounds.
Management and Outcomes of High-energy Pilon Fractures: A Case of King Saud Medical City, KSA
Authors: Alshammari Ahmed Onayzan , Abdalrahman Ahmed Mohammed Ahmed , Serhan Hani , Shogair Majed Mouaffek Majed , Alyassain Hussain , Almustanir Bashah Mohammad Saleh , Alharbi Hani Nouran , Alshahrani Fahd , Alsadoon Mashael Sultan , Alhabobi Abdulmohsin Adnan , Idris Saadeldin Ahmed 
Published: October 2023

ABSTRACT

Background:
Despite being uncommon, pilon fractures are of interest to orthopedic surgeons because of the awkwardness of their treatment. Although various surgical techniques were used, poor outcomes are frequently encountered, and complications are highly prevalent.

Objective:
The objective of this study was to evaluate the clinical and radiographic outcomes of pilon fractures treated with a two-stage technique.

Materials and Methods:
The study included patients with tibial pilon fractures who had undergone two-stage procedures in King Saud Medical City (April 2017–March 2022). Fractures were categorized based on the Arbeitsgemeinschaftfur Osteosynthesefragen (AO) classification method. Outcomes were measured by the American Orthopedic Foot and Ankle Society (AOFAS) scoring system.

Results:
Twenty-one patients had tibial pilon fracture. Open fractures were seen in 23.8%, the majority was Gustilo type II in 60%. The mean follow-up was 24.7 months. The majority (47.6%) was AO type 43-B. Osteoarthritis was developed in 61.9%, and none mandates arthrodesis. Mean AOFAS was 86.91 points, it was excellent in 38.1%. Type 43 C fracture significantly had a poorer AOFAS score (P = 0.021). AOFAS score was significantly affected by fracture grade and association with fibular fracture, P = 0.025, and P = 0.019, respectively.

Conclusion:
Treatment for severe pilon fractures with a two-stage protocol yields favorable outcomes. Fewer soft-tissue complications and better articular reconstruction were the main benefits.
Isolated Muscle Activation Exercises on Lumbopelvic Muscle Strength and Lumbar Range of Motion among Bike Riders
Authors: Abinaya A. , Imtiaz G. Yasmeen 
Published: October 2023

ABSTRACT

Background:
Two-wheelers are the most important means of commuting as they provide fast transportation at a low cost in India. Acquired sitting posture for a prolonged period on the bike increases the fatigue level of the Lumbopelvic muscles.

Objective:
The study aims to find out whether there is a difference in Lumbopelvic muscle strength and lumbar range of motion (ROM) between bike riders and non-bike riders and to find out the acute effect of isolated muscle activation exercises on Lumbopelvic muscle strength and lumbar ROM among bike riders.

Methodology and Procedure:
It is a quasi-experimental study in which the lumbopelvic muscle strength and lumbar ROM were measured for both bike riders (15) and nonbike riders (15). Isolated lumbopelvic muscle activation exercises were given to bike riders. Postintervention measurement of lumbopelvic muscle strength and lumbar ROM was measured after 10 days. Outcome measures: were manual muscle testing, modified MRC grading for muscle strength and modified-modified Schober test for lumbar ROM.

Results and Conclusion:
Results show that the bike riders group has significantly reduced lumbopelvic muscle power and lumbar spine ROM than nonbike riders and isolated lumbopelvic muscle activation exercise has a significant effect on lumbopelvic muscle strength and lumbar ROM in bike riders.
Association of CORADS Classification and Cardiorespiratory Fitness Profile among Symptomatic and Asymptomatic Post-Coronavirus Disease 2019 Individuals
Authors: Hariharan S. , Gayathri K. , Abishek J. R. , Priya M. Anbu 
Published: October 2023

ABSTRACT

Background:
Physiotherapy treatment is focused for coronavirus disease 2019 (COVID-19) patients in critical, acute, and postacute phases, and the physiotherapists have the responsibility of recovering COVID-19 individuals back to their usual quality of life (QOL). Hence, evaluating the COVID-19 survivor’s QOL is important to improve their independence. Objective: This study aims to assess the patient’s cardiorespiratory fitness in association with their CORADS classification and QOL in post-COVID-19 individuals is essential during this pandemic.

Methodology:
A retrospective study was conducted with 60 post-COVID-19 individuals who were recruited by convenience.

Result:

P value of symptomatic and asymptomatic is 0.001, which is considered significant based on their VO2, and that the mean difference, standard error difference, and 95% confidence interval of the difference for both are −6.68, 0.73, and −8.14, respectively. The physical component of QOL is significant in symptomatic individuals (0.005), but all other components are nonsignificant.

Conclusion:
The impact of COVID-19 on health-related QOL and cardiorespiratory fitness is higher in symptomatic individuals than symptomatic individuals.
Computational Insights Into the Epilepsy-related Phytoconstituents of Acacia farnesiana: In silico Analysis, Molecular Modeling, and ADMET Profiling
Authors: Gupta Shristi , Mittal Payal , Arya Girish Chandra 
Published: October 2023

ABSTRACT

Objective:
This study aimed to evaluate the anticonvulsant potential of phytochemicals from Acacia farnesiana using molecular docking and compare their binding affinities with ethosuximide, a common anticonvulsant. Additionally, we conducted a comprehensive ADMET analysis of leucoxol, a promising phytochemical with strong docking scores against leucine-rich glioma-inactivated protein 1 (PDB ID-5Y30).

Methods:
Auto Dock Vina was employed for in silico analysis to predict binding affinities. Leucoxol exhibited significantly higher binding affinity (-7.9 kcal/mol) than ethosuximide (-4.9 kcal/mol), suggesting superior anticonvulsant potential. We thoroughly examined leucoxol’s ADMET profile to assess its pharmacokinetic and toxicological properties.

Results:
Comparative analysis indicated that leucoxol may be a more effective anticonvulsant with reduced toxicity compared to ethosuximide. It displayed strong binding and a favorable ADMET profile.

Conclusion:
Phytochemicals from Acacia farnesiana, especially leucoxol, exhibit promising binding affinities compared to ethosuximide, indicating their potential as anticonvulsant agents. Leucoxol, in particular, demonstrates strong anticonvulsant potential and a favorable ADMET profile, making it a candidate for further research as an anticonvulsant with reduced toxicity. However, additional experimental and clinical investigations are needed to confirm their efficacy and safety in treating convulsive disorders.
Study of Knowledge, Attitude, and Practice of Prescribing Generic Medicines by Resident Doctors at a Tertiary Care Teaching Hospital
Authors: Dudhia Sneh Hemantbhai , Parmar Kesha Ajaykumar , Mehta Maulin Dhiren 
Published: October 2023

ABSTRACT

Context:
In this era of rapidly rising health-care costs, generic medications offer a more cost-effective alternative to branded medications.

Aims:
The main objective of this study is to evaluate junior (resident) doctors’ knowledge, attitude, and practice regarding the prescription of generic medications in a tertiary care teaching hospital.

Settings and Design:
It is an observational, cross-sectional study held at a tertiary care teaching hospital.

Materials and Methods:
An online, prevalidated questionnaire was used for this study.

Results:
A total response of 102 resident doctors was recorded. 75.70% (78) of the participants responded positively that generic medicines are cheaper than branded medicines. 68.90% (71) of participants had knowledge regarding Jan Aushadhi Yojana and generic medicine stores. About 90.30% (93) of participants positively suggested conducting a training program to increase the awareness regarding generic medicines and 86.40% (89) of participants suggested promoting the use of generic medicines. However, 26.20% (27) of participants had not read any article on generic medicines and 30.10% (31) participants disagreed with the substitution of a branded drug with a generic medicine by pharmacists. Sixty-five percent (67) of the participants preferred to prescribe generic medicines and 79.60% (82) of participants suggested that they are willing to encourage the patients to use generic medicines.

Conclusions:
Our study found that the resident doctors were well-versed in the idea of generic medications and their advantages. However, promoting training initiatives, setting up workshops, running journal club meetings, continuing medical education, etc., need to be planned to boost the number of prescriptions for generic drugs.
Antioxidant Properties of Methanolic and Acetone Extracts of Pictacia palaestina, Verbena triphylla and Nigella sativum
Authors: Alabdallat Nessrin Ghazi , Alanazi Hana 
Published: October 2023

ABSTRACT

Aims:
The aim of the study was to estimate the antioxidant characteristics of methanolic and acetone extracts of Pistacia palaestina, Verbena triphylla, and Nigella sativa.

Materials and Methods:
The biochemical antioxidant assays that used were total phenols and flavonoids, total antioxidant capacity, ferric reducing power and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging.

Results:
The maximum antioxidant capacity and the ferric-reducing power of the examined plant extracts were shown in P. palaestina/methanol whereas N. sativa L./methanol was the lowest. The maximum scavenging activity of DPPH was shown in N. sativa L./acetone (IC50 = 2688 μg/ml), followed by, V. triphylla/acetone (IC50 = 573.5 μg/ml), N. sativa/methanol (IC50 = 437.7 μg/ml), V. triphylla/methanol (IC50 = 64 μg/ml), and P. palaestina methanol and acetone extracts (IC50 = 9.5 μ/g) being the lowest.

Conclusion:
The findings with methanol extract of P. palaestina methanol shown the highest antioxidant property which and can be due to the presence of high quantity of phenols and flavonoids in the methanol extract of this plant; moreover, N. sativa acetone extract has maximum DPPH-free radical scavenging activity. This may be because the acetone extract demonstrated capabilities to scavenge radicals remarkably for Nigella sativa L seeds.
Stability Testing of Modified Amino Acid Solutions in Neonatal Parenteral Nutrition Formulations
Authors: Premakumar Chandini Menon , Dwyer Paul , Herwitker Shakeel , Turner A. Mark , Morgan Colin 
Published: October 2023

ABSTRACT

Context:
Aqueous neonatal parenteral nutrition (PN) formulations are made up of glucose, amino acids (AAs), and electrolytes. Different AA solutions are used to make these formulations. Most licensed products do not meet the nutritional needs of preterm neonates specifically for arginine. Therefore, AA solutions with additional arginine need to be developed and proven stable before being tested for clinical efficacy. PN formulations containing modified AA solutions with 15% arginine were tested in this study.

Aims:
This study aims to design a stability testing protocol and assign a shelf life to the modified PN formulations being tested.

Methods:
Physical tests including appearance, pH, optical rotation, ultraviolet absorbance, and subvisible particle count tests as well as chemical analysis using AA assay were performed in this study.

Results:
Resampling of PN bag samples posed a risk for oxidation and hence single sampling of fresh PN bags for each test point is the best practice for PN stability testing trials. AA assay is a feasible method to ensure AA stability in PN formulations.

Conclusion:
Modified PN formulations with 15% arginine were stable for 90 days without the addition of the trace element solution. Upon the addition of trace elements, the shelf life was limited to 7 days.
Quantitative Estimation of Quercetin of Some Selected Edible Plants of West Bengal by High-performance Thin-layer Chromatography Densitometry Method
Authors: Das Barnali , Saha Prerona , Maity Nandadulal 
Published: October 2023

ABSTRACT

Introduction:
Quercetin is a polyphenol, widely found in most edible fruits and vegetables. This plant pigment provides cardiovascular, anti-inflammatory, antidiabetic, asthma, and many more health benefits.

Objective:
The aim of this study is to quantify the quercetin by high-performance thin-layer chromatography (HPTLC) method from the methanolic leaf extracts of three edible plants of Bengal, viz., Nyctanthes arbor-tristis L., Oxalis corniculata L., and Polygonum plebeium R.Br.

Materials and Methods:
HPTLC was carried out on aluminum-backed plate precoated with silica gel 60 F254, using the solvent system of toluene, ethyl acetate, formic acid, and methanol (5.5:3:1:0.5 v/v/v/v). The method validation was done according to the International Conference on Harmonization guidelines in terms of linearity, limit of detection, limit of quantification, accuracy, precision, and specificity.

Results:
The desired compound was well separated using the solvent system toluene, ethyl acetate, formic acid, and methanol (5.5:3:1:0.5 v/v/v/v) which gave a sharp and well-defined band with Rf 0.60 for quercetin. The calibration curves showed a good linear correlation coefficient (R
2 = 0.9774). The linearity range was found to be 20–100 (μg/spot). Among the selected plants, the highest amount of quercetin was found in the leaf extracts of O. corniculata L. (220.035 ± 0.06 mg/100 g) and the lowest for N. arbor-tristis L. (31.253 ± 0.99 mg/100 g).

Conclusion:
The proposed HPTLC method for quercetin estimation was found to be simple, cost-effective, precise, and accurate and can be used for the quality control of plant material. O. corniculata L. was found to be a potent source of quercetin as it possesses a decent amount of quercetin.
Evaluation of Root Coverage Procedures Using Root Coverage Esthetic Score System – A Case Series
Authors: Sidharthan Sangamithra , Babu K. Vijay , Subramanian Swetha , Farooqui Arjumand , Ubale Prerna 
Published: October 2023

ABSTRACT

Background:
Gingival recession, characterized by root surface exposure due to apical gingival margin migration, is a prevalent condition in the general populace, frequently prompting patient intervention. Mucogingival therapy may be indicated for recession control, plaque management, and dentin hypersensitivity; nevertheless, the consideration of esthetics correction as a therapeutic rationale is increasingly significant in contemporary clinical practice.

Objective:
The goal of this case series was to evaluate the most esthetic root coverage procedure of the three procedures performed.

Methods:
Patients with localized recession were treated with three different root coverage procedures, namely the free gingival graft (FGG), connective tissue graft + coronally repositioned flap (CTG + CAF), and platelet-rich fibrin (PRF) + coronally positioned flap. The root coverage procedures were assessed for the root coverage esthetic score (RES) system after 6 months. The RES scores of these procedures were compared to determine if one procedure offered a greater esthetic result over the other.

Results:
All three procedures were effective in obtaining root coverage and improved clinical parameters. However, CTG with CAF, along with complete root coverage (CRC), produced a better esthetic outcome than other root coverage procedures compared in this case series. The success of root coverage procedures is based on the overall esthetic outcome along with CRC. Thus through the incorporation of the RES into everyday clinical practice, clinicians can enhance the accuracy and consistency of their evaluations, leading to improved patient care and optimizing treatment planning.