bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASK1/p38 axis inhibition blocks the release of mitochondrial “danger signals” from hepatocytes and suppresses progression to cirrhosis and liver cancer
Authors: Peng Zhenwei , Wei Guangyan , Huang Pinzhu , Matta Heansika , Gao Wen , An Ping , Zhao Shuangshuang , Lin Yi , Tan Li , Vaid Kahini , Skelton-Badlani Disha , Nasser Imad , Budas Grant , Lopez David , Li Li , Breckenridge David , Myers Rob , McHutchison John , Kuang Ming , Popov Yury V. 
Published: February 2024

Background and Aims:
Apoptosis Signal–regulating Kinase 1 (ASK1) is activated by various pathological stimuli and induces cell apoptosis through downstream p38 activation. We studied the effect of pharmacological ASK1 inhibition on cirrhosis and its sequelae using comprehensive preclinical in vivo and in vitro systems.

Approach and Results:
Short-term (4–6 wk) and long-term (24–44 wk) ASK1 inhibition using small molecule GS-444217 was tested in thioacetamide-induced and BALB/c.Mdr2−/− murine models of cirrhosis and HCC, and in vitro using primary hepatocyte cell death assays. Short-term GS-444217 therapy in both models strongly reduced phosphorylated p38, hepatocyte death, and fibrosis by up to 50%. Profibrogenic release of mitochondrial DAMP mitochondrial deoxyribonucleic acid from dying hepatocytes was blocked by ASK1 or p38 inhibition. Long-term (24 wk) therapy in BALBc.Mdr2−/− model resulted in a moderate 25% reduction in bridging fibrosis, but not in net collagen deposition. Despite this, the development of cirrhosis was effectively prevented, with strongly reduced p21+ hepatocyte staining (by 72%), serum ammonia levels (by 46%), and portal pressure (average 6.07 vs. 8.53 mm Hg in controls). Extended ASK1 inhibition for 44 wk in aged BALB/c.Mdr2−/− mice resulted in markedly reduced tumor number and size by ~50% compared to the control group.

Conclusions:
ASK1 inhibition suppresses the profibrogenic release of mitochondrial deoxyribonucleic acid from dying hepatocytes in a p38-dependent manner and protects from liver fibrosis. Long-term ASK1 targeting resulted in diminished net antifibrotic effect, but the progression to liver cirrhosis and cancer in BALBc/Mdr2

−/−
mice was effectively inhibited. These data support the clinical evaluation of ASK1 inhibitors in fibrotic liver diseases.
Strategies and Application of Compression Sutures With a Modified Technique for Rapid Resolution of Large (Grade III) Hydrops: A Prospective Interventional Study
Authors: Daza Jessica , Ramappa Muralidhar , Murthy Somasheila , Chaurasia Sunita 
Published: February 2024

Purpose:
The aim of this study was to describe the strategies and outcomes, with a modified technique, of compression sutures in large acute hydrops.

Methods:
This was a prospective interventional study in 29 eyes of 28 patients who underwent compression sutures using a modified technique. The degree of resolution after surgical intervention was quantified by 3 masked observers, using the slit-lamp photographic documentation and optical coherence tomography. The degree of resolution, best-corrected visual acuity, and complications were analyzed.

Results:
The mean age was 20.89 (7–46) years. Five patients had pellucid marginal degeneration (pellucid marginal corneal degeneration), 23 had keratoconus, and 1 had posttrauma hydrops. The preoperative visual acuity was hand motions in all eyes. The reduction in edema was 76% on day 1, 91.6% on 6 ± 2 days, 98.6% on 18 ± 3 days from surgical intervention. The baseline pachymetry assessed on optical coherence tomography was beyond measurement in 26 eyes. The mean pachymetry at day 1 was 704 μm (range 480–950) which reduced to 607 (range 422–850) microns at 6 ± 2 days and 518 (range 415–718) microns at 18 ± 3 days postintervention (P < 0.0001). The mean duration between the surgery and complete suture removal was 48 (35–68) days. No suture-related complications were noted. Twenty eyes could attain good visual rehabilitation with glasses/contact lenses (vision could not be assessed in 5 eyes). Penetrating keratoplasty was performed on 1 patient.

Conclusions:
Compression sutures using the modified technique was safe and effective in the rapid resolution of acute hydrops in keratoconus and pellucid marginal corneal degeneration. No complications were noted, and visual restoration with spectacles and contact lenses was satisfactory.
Disseminated Mycobacterial Infection With Reactive Polyarthritis (Poncet’s Disease) During Immune-suppressive Treatment Including Ustekinumab for Pediatric Crohn’s Disease
Authors: Minotti Chiara , Costenaro Paola , Donà Daniele , Zuliani Monica , Bosa Luca , Leon Alberta , Perilongo Giorgio , Gaio Paola , Martini Giorgia , Cananzi Mara 
Published: February 2024

Background:
The incidence of pediatric inflammatory bowel disease is increasing. tumor necrosis factor alpha inhibitors medicines improved the prognosis of affected subjects. Nonetheless, a proportion of patients do not respond or lose response to treatment. Newer biologics, like ustekinumab, have been approved for adults. The pediatric off-label use of these drugs is increasing, despite limited safety evidence. We report a case of disseminated mycobacterial infection (MI) presenting with reactive polyarthritis (Poncet’s disease, PD) in a girl with Crohn’s disease receiving various immunosuppressants, including ustekinumab.

Case Report:
A 12-year-old girl with Crohn’s disease was admitted for acute-onset migratory polyarthritis of large and small joints and opioid-resistant pain. She had recently received adalimumab and methotrexate and was currently under treatment with ustekinumab. She was vaccinated with Bacillus Calmette-Guérin and screened for tuberculosis before starting immunosuppressants. Interferon-gamma release assay, Mantoux test and chest computed tomography scan were negative. Disseminated MI with PD was diagnosed following positive cultures for Mycobacterium tuberculosis complex in blood and intestinal biopsies (with negative in synovial fluid and gastric aspirate). Whole-exome sequencing did not identify any genetic susceptibility to MI. Antituberculosis treatment eradicated MI.

Conclusions:
Children with inflammatory bowel disease receiving combination immunosuppressive treatments including tumor necrosis factor alpha inhibitors and anti-IL-12/23 agents are at higher risk for MI. Disseminated MI should be considered and ruled out in these patients when presenting with pulmonary, extrapulmonary or unusual clinical manifestations, like PD. The collection of multiple specimens (including intestinal biopsies) for mycobacterial culture is recommended when mycobacterial disease is suspected.
Clinical outcomes and rotational stability after implantation of a monofocal toric intraocular lens with textured haptics in normal vs high axial lengths
Authors: Brar Sheetal , Ganesh Sri , Karegowda Manjushree 
Published: February 2024

Purpose:
To compare the clinical outcomes and rotational stability after implantation of a toric intraocular lens (IOL) with textured haptics in eyes with normal vs high axial lengths (ALs).

Setting:
Nethradhama Superspeciality Eye Hospital, Bangalore, India.

Design:
2-arm, retrospective comparative study.

Methods:
This retrospective study included 114 eyes of 114 patients who underwent femtolaser cataract surgery followed by implantation of the HOYA Vivinex Toric monofocal IOL (Model XY1A-SP), of which 62 and 52 eyes belonged to normal (≤23.9 mm) and high (≥24 mm) AL groups, respectively. 1 week and 3 months postoperatively, clinical outcomes and rotational stability of the toric IOL was evaluated.

Results:
3 months postoperatively, % eyes achieving refractive astigmatism accuracy within ≤0.50 diopter, was 100% (n = 62) in the normal vs 94% (n = 49) in the high AL group. All eyes that is, 100% (n = 62) in the normal and 96.15% (n = 50) eyes in the high myopia group were <5 degrees of the intended axis. The mean change in postoperative rotation from 1 week to 3 months was 0.28 ± 0.09 degrees in the normal, and 0.30 ± 1.11 degrees in the high AL group (P = .80). No significant correlation was observed between AL and white-to-white diameter with 1-week postoperative rotation values. No eye required repositioning of toric IOL for significant misalignment.

Conclusions:
No significant differences were observed for clinical outcomes and postoperative rotational stability between eyes with normal and high ALs, suggesting excellent rotational stability of the Vivinex Toric IOL with textured haptics in all eyes, irrespective of the preoperative AL measurements.
The effect of slow-release vaginal dinoprostone on maternal and fetal oxidative stress in term pregnancies complicated by oligohydramnios: Prospective cohort study
Authors: Yilmaz Gamze , Neselioglu Salim , Aydogdu Fatma Ece , Erel Ozcan , Uzunlar Ozlem , Moraloglu Tekin Ozlem 
Published: February 2024

Background:
To evaluate changes in oxidant status using thiol/disulfide homeostasis in mothers and fetuses after induction of labor with slow-release vaginal dinoprostone inserts.

Methods:
A total of 70 pregnant women were divided into two groups. Thirty-five women in whom labor was induced with slow-release vaginal dinoprostone inserts (10 mg of prostaglandin E2, group A) were compared before and after the administration. The other 35 women, who were followed up spontaneously during labor (group B), were included as a control group. Both groups were diagnosed with isolated oligohydramnios without signs of placental insufficiency. The thiol/disulfide homeostasis parameters were calculated before medical induction and after removal of the insert at the beginning of the active phase of labor. Maternal and cord blood values were measured in both groups.

Results:
Although the balance shifted to the antioxidant side after the slow-release vaginal dinoprostone insert was applied, there was no significant difference in maternal oxidative load compared to the pre-application status (5.32 ± 014/5.16 ± 0.15, p = 0.491). Despite the shift toward the antioxidant side, maternal antioxidants were still significantly lower in the group that received slow-release vaginal dinoprostone at the beginning of the active phase of labor than in the control group (295.98 ± 13.03/346.47 ± 12.04, respectively, p = 0.009). There was no statistically significant difference in terms of oxidative balance or newborn Apgar score (p > 0.05).

Conclusion:
Induction of labor with slow-release vaginal dinoprostone inserts in pregnancies with isolated oligohydramnios does not cause further oxidative stress and is safe for both mothers and neonates in terms of oxidant load by thiol/disulfide homeostasis.
Work-Related Mental Health Problems in Switzerland
Authors: Scholz-Odermatt Stefan M. , Zyska Cherix Anja 
Published: February 2024

Objective
The study identifies work-related risk factors that are relevant to mental health and quantifies their influence. This allows estimation of risk levels for individual workplaces and of the proportion of occupational causation in the emergence of mental health problems.

Methods
Swiss Health Survey data, containing information on several potential risk factors and health indicators that cover aspects of mental health, were used in multiple multivariate logistic regression analyses.

Results
Stress was the predominant risk factor, followed by exposure to violence, unergonomic work processes, and work that conflicted with family life. Hotel and restaurant industries and health and social services had high exposure to risk factors. One of 20 workplaces was deemed high-risk based on an odds ratio >4.

Conclusions
Up to one-third of mental health problems within the active workforce may have highly predominant occupational causation.
Prevalence, Knowledge, and Perceived Impact of Urinary Incontinence in Female Collegiate Athletes
Authors: Stickley Lois , McDowell Debra 
Published: February 2024

Background:
Urinary incontinence (UI) is prevalent among collegiate female athletes at much higher rates than in sedentary women. Athletes participating in high-impact sports have a greater risk of UI, which can negatively impact performance.

Objectives:
The objectives of this study were (1) to assess the prevalence of UI among female collegiate athletes, (2) to evaluate the impact of incontinence on individual function and perceived athletic performance, and (3) to determine athletes' awareness of physical therapist management of UI.

Study Design:
An observational, cross-sectional design with convenience sampling was used.

Methods:
Two hundred seventy-nine female collegiate student athletes were invited to participate in an online survey. The survey included informed consent, questions about age and athletic participation, and questions about participants' experience with UI and knowledge of pelvic floor physical therapy. Descriptive statistics were performed to identify frequencies for age and sports/athletic participation. Frequencies for all variables were used as an exploratory measure to assess sample characteristics. Pearson correlation analyses were used to examine relationships between demographic variables and survey responses.

Results:
Online surveys were received from 52 respondents. Twenty-one (40.4%) reported never experiencing UI. In those who did report UI, it was consistent with activities related to stress UI. Most respondents were not aware that physical therapists treat pelvic floor dysfunction including UI.

Conclusion:
Prevalence of UI among female college athletes was consistent with prior research. More education is needed in this population on the impact and treatment of UI, including the role of physical therapists.
Racism and Nursing Leadership in Massachusetts
Authors: Banister Gaurdia , Harris Allyssa , Masson Patricia , Dzurec Laura , Daniello Carmela , Raymond Nadia , Yactayo Jhoana , Horick Nora , Huang Weixing 
Published: February 2024

BACKGROUND
Nursing in the United States has evolved within the same historical context that has reproduced and spread racism worldwide. Nurse administrators are integral to the quality of nurses' practice and play a key role in eliminating racial injustice in places of work.

PURPOSE
Using a feminist and critical race feminist framework, this study examined Massachusetts nurses' experiences of racism in their places of work, focusing on nurse administrators' influence on the nonadministrator (staff nurse) experience of racism experiences before and after George Floyd's death.

METHODS
An investigator-developed, electronic survey was sent to Massachusetts professional nursing organizations for distribution to their members in 2021. Two hundred nineteen nurse respondents completed Likert-scale and open-ended branching logic survey questions to yield the quantitative and qualitative data analyzed for this mixed-methods study.

FINDINGS
Nurse administrators were: 1) more likely than staff nurses to state that policies and meetings to address racism and diversity, equity, and inclusion had taken place before and after George Floyd's murder; and 2) less likely than staff nurses to directly experience racism at the hands of a colleague or a superior. Nurse administrators influence staff nurses' experiences of racism.
The Impact of Moral Injury on Self-reported Work Performance in Hospital Nurses Following the Global Pandemic Surge
Authors: Callis Annette (Browning) , Saul Trisha , Bindler Ross J. 
Published: February 2024

OBJECTIVE
The aim of this study was to determine relationships between moral injury (MI) and self-reported nurse work performance (NWP) among hospital nurses after the COVID-19 pandemic surges.

BACKGROUND
Previously studied in the military, nurse MI became evident due to the pandemic. No previous studies have examined the impact of MI on NWP. Few studies have attended to how MI in nurses can be addressed by nursing leadership.

METHODS
A convenience sample of 191 nurses from 7 hospitals in Southern California participated in a multisite correlational survey-design study.

RESULTS
Significant levels of MI occurred in 57% (n = 114) of participants. Increased levels of MI were a significant predictor of decreased levels of self-reported NWP. Younger and less experienced nurses reported greater levels of MI.

CONCLUSIONS
This study relates MI in nurses to NWP. There is a need for further research to assist nursing administrators in ameliorating MI in nurses and in preparing for the impact of MI on the nursing workforce in future emergent situations.
Diminution of Primary Cilia in the Stromal Cells at the Tumor-stromal Interface Correlates With an Aggressive Tumor Biology in the Urothelial Carcinoma of the Urinary Bladder
Authors: Kapaganti Vamsi K. , Purkait Suvendu , Nayak Prasant , Biswas Dipanwita , Mohamedali Rasheeda , Adhya Amit K. , Mitra Suvradeep 
Published: February 2024

Background and Aims:
Primary cilia (PC) are cellular organelles that regulate the cellular homeostasis. They are the seats of many oncogenic pathways and indirectly regulate the epithelial-mesenchymal transition (EMT) and extracellular matrix, both critical for the tumor microenvironment (TME). Though there are a few studies highlighting the alteration of PC in the tumor cells of various malignancies, none depict the PC in the stromal cells in the urothelial carcinoma of the urinary bladder (UC), the stromal cells being an essential component of TME. Therefore, we intend to evaluate the PC in the stromal cells at the tumor-stromal interface in UC.

Methods:
Immunohistochemistry for acetylated-α-tubulin (for PC), Ki67, E-cadherin, and SNAI1 was performed in 141 cases of UC and 5 normal controls, and primary cilium: nucleus (C:N) ratio was counted in the stromal cells at the tumor-stromal interface. The C:N ratio was correlated with various clinical and histopathological parameters.

Results:
The C:N ratio showed significant diminution from normal control (mean=0.75) to low-grade UC (mean=0.24) (P=0.001) to high-grade UC (mean value=0.17) (P=0.001). There was a significant diminution of the C:N ratio from the noninvasive to invasive UC (P=0.025). The C:N ratio did not show any correlation with EMT although negatively correlated with the Ki67 index (r=−0.32; P=0.001), and a higher ratio showed a trend with a higher recurrence-free survival (P=0.07).

Conclusions:
The diminution of the PC in the stromal cells at the tumor-stromal interface is an early event and correlates with an aggressive tumor biology of UC.
Decreased Bed Mobility Function Is Associated With Postdischarge Mortality for Cancer Patients in Inpatient Rehabilitation
Authors: Roy Ishan , Marks Julia , Fram Julia , Jayabalan Prakash , Spill Gayle 
Published: February 2024

Objective
The establishment of rehabilitation goals for hospitalized cancer patients depends on accurate medical prognosis and matching goals to clinical timelines. Current tools for estimating prognosis are limited. We hypothesized that bed mobility is a predictor of mortality in cancer patients admitted to inpatient rehabilitation.

Design
In a retrospective cohort of 187 subjects with nonneurologic cancer admitted to inpatient rehabilitation, Functional Independence Measure scores and 6-mo mortality were analyzed.

Results
In the cohort, survival rate was 71% at 6 mos. In univariate analysis, discharge bed mobility score (odds ratio = 0.75, 95% confidence interval = 0.61–0.90, P = 0.003), bed mobility Functional Independence Measure gain (odds ratio = 0.66, 95% confidence interval = 0.51–0.85, P = 0.002), and bed mobility Functional Independence Measure efficiency (odds ratio = 0.011, 95% confidence interval = 0.00032–0.21, P = 0.006) were inversely associated with 6-mo mortality after discharge from inpatient rehabilitation facility. In multivariate analysis with additional motor Functional Independence Measure items, only bed mobility (odds ratio = 0.73, 95% confidence interval = 0.54–0.97, P = 0.029) and grooming (odds ratio = 0.79, 95% confidence interval = 0.63–0.99, P = 0.041) were independently associated with mortality.

Conclusions
Lower discharge and lower change in bed mobility Functional Independence Measure scores are associated with mortality in cancer patients in inpatient rehabilitation. Bed mobility could serve as a clinical tool for estimating medical prognosis in hospitalized cancer patients and should be validated in prospective studies.
Efficacy of Targeted Scapular Stabilization Exercise Versus Conventional Exercise for Patients With Shoulder Pain
Authors: Tang Lan , Chen Kang , Huang Lihua , Liang Juan , Wang Man , He Lanjuan , Liu Lintao , Li Lixing , Ma Yanhong 
Published: February 2024

Objective
The aim of the study is to investigate the efficacy of targeted scapular stabilization exercise in shoulder pain.

Design
This is an evaluator-blinded, multicenter, randomized controlled trial. The scapular stabilization exercise group (n = 45) received scapular stabilization exercise based on the type of scapular dyskinesis for 6 wks; the conventional exercise group (n = 45) received pendulum, wall climbing and stick exercises for 6 wks. Constant-Murley score, numerical rating scale, range of motion, type of scapular dyskinesis, lateral scapular sliding test, pectoralis minor index, scapular index, and satisfaction were assessed at baseline, 2-, 4-, and 6-wk treatment as well as a 6-wk follow-up.

Results
After a 6-wk intervention, the improvement of Constant-Murley score was greater in the scapular stabilization exercise group than in the conventional exercise group, and improvement continued at the 6-wk follow-up (F = 15.39, P < 0.001, partial η2 = 0.17). The results were also significant for numerical rating scale during activity, lateral scapular sliding test, pectoralis minor index, type of scapular dyskinesis, and satisfaction in favor of the scapular stabilization exercise group (P < 0.05).

Conclusions
Targeted scapular stabilization exercise is an effective intervention program that might be applied to the rehabilitation of shoulder pain.
Postbariatric Panniculectomy: Postoperative Complications by Weight Loss Surgery Type
Authors: Fahmy Joseph N. , Kong Lingxuan , Benítez Trista M. , Sanders Hayley M. , Wang Lu , Chung Kevin C. 
Published: February 2024

Background:
More than 250,000 patients undergo bariatric surgery each year in the United States. Approximately 21% will undergo subsequent body contouring after massive weight loss. Patients with prior bariatric surgery are at a greater risk for complications relative to the general population. However, it is unknown whether bariatric surgery type is associated with differential complication risk after panniculectomy.

Methods:
A retrospective chart review of postbariatric patients who underwent abdominal panniculectomy at a single large quaternary care center was performed. Postoperative complications were graded according to the Clavien-Dindo classification. Descriptive statistics, multivariable logistic regression, and power calculations were performed.

Results:
In total, 216 patients were included. Restrictive bariatric surgery accounted for 48.6%, whereas 51.3% had a history of malabsorptive bariatric surgery. The overall rate of complications was 34.3% (restrictive, 36.2%; malabsorptive, 32.8%; P = 0.66). Wound complications were observed in 25.5% (n = 55) of patients. Systemic complications occurred in 11.1% of patients overall, with statistically similar rates between restrictive and malabsorptive groups. After adjusting for both patient and operative factors, no significant difference in total complications (OR, 1.15; 95% CI, 0.47 to 2.85; P = 0.76), systemic complications (OR, 0.26; 95% CI, 0.05 to 1.28; P = 0.10), or wound complications (OR, 2.31; 95% CI, 0.83 to 6.41; P = 0.11) was observed.

Conclusions:
Complication rates following panniculectomy in bariatric surgery patients are high and predominantly related to wound healing. No significant difference between type of bariatric surgery and complication risk was found.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.