bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of low-intensity warm-up associated with blood flow restriction: A study protocol for a randomized controlled clinical trial
Authors: Filho Carlos Alberto Toledo Teixeira , Vendrame Julia Waszcuzuk , Cavina Allysiê Priscilla de Souza , Junior Eduardo Pizzo , Silva Gabriel Martins Da , Matsumoto Renan Alves , Brandão Guilherme Henrique Da Silva , Vanderlei Franciele Marques 
Published: October 2023

Abstract
Introduction: Warm-up has the function of preparing the body structures for a given task to be performed during sports, increasing body and muscle temperature, focused on improving performance. Therefore, the use of the blood flow restriction technique (BFR) can be seen as a promising alternative for promoting greater mechanical and muscular stress, thus providing a more efficient warm-up and optimizing performance.
Objectives: to analyze the effects of RFS used during low-intensity warm-up compared with low-intensity and high-intensity warm-up without RFS on performance, skin surface temperature, and perceptual and muscular outcomes.
Methods: a randomized controlled clinical trial will be carried out, with 33 amateur soccer players aged between 18 and 35 years who will be randomly divided into three groups: low intensity warm-up without BFR (30% VO2peak), high intensity warm-up without BFR (80% VO2peak) and low-intensity warm-up associated with BFR (80% of total occlusion pressure) [30% VO2peak-BFR]. All groups will carry out the warm-up protocol and the outcomes will be evaluated at baseline and immediately after the end of the warm-up, as well as 10 and 20 minutes after its completion, which are sequentially: skin surface temperature through thermography; tone, stiffness and muscle elasticity by myotometry, subjective perception of pain by analogue pain scale (VAS); pain threshold through the pressure algometer; subjective perception of exertion by the Borg scale; perception of discomfort in relation to BFR on the Likert-10 scale; 30 meter sprints measured through photocells and vertical jump measured through the force platform. Descriptive statistics will be used and comparisons will be made using the generalized linear mixed model, assuming a significance level of p<0.05.
Discussion: the clinical applicability of this study, if its hypothesis is confirmed, will have as its main focus the performance gain of amateur athletes, preparing them for the game subsequent to the warm-up period, and may also be extended to sports with similar demands, due to the BFR technique being easy to apply and access. Furthermore, BFR during warm-up can also be incorporated within training centers and not just in pre-game moments.
Trial registration number: ClinicalTrials.gov, NCT05523674. Registered on 08 November 2022.
Social Determinants of Health and Disparities in Pediatric Trauma Care: Protocol for a Systematic Review and Meta-Analysis
Authors: Gnanvi Janyce Jivroncia Judith A Eunice , Yanchar Natalie , Freire Gabrielle , Beaulieu Emilie , Tardif Pier-Alexandre , Bérubé Mélanie , Macpherson Alison , Pike Ian , Zemek Roger , Gagnon Isabelle J. , Carsen Sasha , Gabbe Belinda , Gnanou Soualio , Duval Cécile , Moore Lynne 
Published: October 2023

Abstract
Background
Social determinants of health (SDH), including "the conditions in which individuals are born, grow, work, live and age" affect child health and well-being. Several studies have synthesized evidence about the influence of SDH on childhood injury risks and outcomes. However, there is no systematic evidence about the impact of SDH on accessing care and quality of care once a child has suffered an injury. We aim to evaluate the extent to which access to care and quality of care after injury are affected by children and adolescents’ SDH.
Methods
Using Cochrane methodology, we will conduct a systematic review including observational and experimental studies evaluating the association between social/material elements contributing to health disparities, using the PROGRESS-Plus framework: Place of residence, Race/ethnicity/culture/language, Occupation, Gender/sex, Religion, Education, Socioeconomic status, and Social capital and care received by children and adolescents (≤ 19 years of age) after injury. We will consult published literature using PubMed, EMBASE, CINAHL, PsycINFO, Web of Science, and Academic Search Premier and grey literature using Google Scholar from their inception to a maximum of six months prior to submission for publication. Two reviewers will independently perform study selection, data extraction, and risk of bias assessment for included studies. Risk of bias will be assessed using the ROBINS-E and ROB-2 tools respectively for observational and experimental study designs. We will analyze data to perform narrative syntheses and if enough studies are identified, we will conduct a meta-analysis using random effects models.
Discussion
This systematic review will provide a synthesis of evidence on the association between SDH and pediatric trauma care (access to care and quality of care) that clinicians and policymakers can use to better tailor care systems and promote equitable access and quality of care for all children. We will share our findings through clinical rounds, conferences, and publication in a peer-reviewed journal.
Systematic review registration
: This review has been registered in the PROSPERO database (ID: CRD42023408467)
Emergent Pericardiocentesis is Lifesaving in Management of Acute Pericardial Tamponade Associated with Left Ventricular Free Wall Rupture "CASE REPORT"
Authors: Habibi Hamzeh , Nejad Sam Zeraatian , Amirfarhangi Abdollah , Piriai Elham , Vahmani Fatemeh , Rahvar Mostafa 
Published: October 2023

Abstract
Introduction
Ventricular free wall rapture and subsequent pericardial tamponade are among the most challenging and life-threatening complications of acute myocardial infarction (MI), which is associated with a high mortality rate.
Case presentation
in this report, we describe a 62-year-old man who suffered from LV free wall rupture and pericardial tamponade following MI. Despite relative contraindication of percutaneous pericardiocentesis in post MI tamponade, timely diagnosis and immediate pericardiocentesisfollowed by emergency surgery, resulted in patient’s survival.
conclusions
This study suggests that immediate pericardiocentesis in hemodynamically unstable patients may be life-saving before the arrival of the surgical team.
Cell Division Cycle-Associated Protein 8 in Pan-Cancer: A Comprehensive Prognostic and Immune Infiltration Investigation
Authors: Zheng Wanrong , Zhong Chengqian , Lai Fobao 
Published: October 2023

Abstract
The Cell Division Cycle-Associated Protein 8 (CDCA8) protein is a vital player in the process of cell division and can influence numerous physiological and pathological events in the body by triggering certain proteins such as cell cycle-controlling proteins, transcription factors, and signal transmission molecules. Despite numerous studies indicating that dysregulation of CDCA8 is prevalent in human cancers, no systematic pan-cancer analysis has been conducted. In this study, we used The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), and Gene Expression Omnibus (GEO) datasets, and several bioinformatics tools to investigate the role of CDCA8 in 33 different tumor types. The results showed that Patients with malignancies that overexpressed CDCA8, such as adrenocortical carcinoma, kidney renal clear cell carcinoma, and liver hepatocellular carcinoma, typically had poor overall survival (OS). We also found that CDCA8 expression was favorably correlated with immune cell infiltration levels in numerous human cancer types. Furthermore, GSEA results showed that overexpression of CDCA8 in human malignancies may accelerate the development of cancer by triggering a number of oncogenic signaling pathways. In conclusion, our comprehensive assessment of the oncogenic activity of CDCA8 in several human cancer types suggests that CDCA8 can be used as a potential therapeutic target and prognostic biomarker in various human cancer types.
Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism
Authors: Li Dan , Li Yujuan , Yang Shengjie , Zhang Xiaonan , Cao Yu , Zhao Ran , Zhao Yixi , Jin Xiao , Lu Jing , Wang Xinyue , Liu Longtao , Wu Min 
Published: October 2023

Abstract
Background
Atherosclerosis is a widely studied pathophysiological foundation of cardiovascular diseases. The gut microbiota and their metabolites are considered independent risk factors for atherosclerosis. Polydatin combined with hawthorn flavonoids (PH), as the extracts of Polygonum cuspidatum Sieb. et Zucc. (P. cuspidatum) and Crataegus pinnatifida Bunge (C. pinnatifida), have shown excellent cardiovascular protective effects. However, the underlying mechanism requires further investigation. Our study aimed to explore the anti-atherosclerotic mechanism of PH through gut microbiota and their metabolites.
Methods
ApoE−/− mice were fed either a normal-chow diet or a high-fat diet. The PH group received varied doses of polydatin and hawthorn flavonoids: a high dose (polydatin 200 mg/kg daily; hawthorn flavonoids 100 mg/kg daily), a medium dose (polydatin 100 mg/kg daily; hawthorn flavonoids 50 mg/kg daily), and a low dose (polydatin 50 mg/kg daily; hawthorn flavonoids 25 mg/kg daily). The control and model groups were administered distilled water (0.2 mL daily). The experiment lasted for 24 weeks.
Results
PH administration significantly reduced lipid and inflammatory cytokine levels, meanwhile, the atherosclerotic lesions in a high-fat diet-induced ApoE−/− mice were significantly decreased. Additionally, PH also inhibited the enhancement of trimethylamine N-oxide (TMAO), trimethylamine (TMA) levels of HFD-induced ApoE−/− mice by regulating the expression of hepatic flavin-containing enzyme monooxygenase 3 (FMO3). 16S rRNA sequencing results demonstrated that high-dose PH treatment reduced Firmicutes/Bacteroidetes ratio, increased the abundance of Actinobacteriota, Atopobiaceae and Coriobacteriaea_UCG-002, and decreased the abundance of Desulfobacterota. Norank_f_Muribaculaceae was enriched in the medium-dose PH and simvastatin groups, and Lactobacillus was mainly increased in the simvastatin and the low-dose PH groups. According to the metagenetic results, functional annotations also suggested that the biological processes of each group mainly focused on metabolism-related processes. Specifically, PH may regulate the abundance of TMA-producing bacteria (Coriobacteriaceae, Desulfovibrio, Muribaculum, and Clostridium) and related enzymes in glycolipid metabolic pathways to exert an important effect on the prevention of atherosclerosis.
Conclusions
Our results suggested that PH could regulate the glucolipid metabolism-related pathway, attenuate inflammatory cytokine levels, and reduce atherosclerotic plaques by remodeling gut microbiota.
Trial registration:
Not applicable.
The effect of pacing at different sites on cardiac function ： A network analysis
Authors: Li Han , Zhang Qian , Wang Qing-Yi , Yang Li-Hong , Xu Jin-Yi 
Published: October 2023

Abstract
Background: The slow arrhythmia caused by sick sinus syndrome and conduction disorder is mainly manifested in palpitation, dizziness, and even syncope. If not treated in time, it will lead to heart failure, shock, and even endanger the life of patients, posing a great threat to the life and health of patients.At present, the most effective treatment is pacemaker implantation.Pacemaker can help excite the patient's heart according to the patient's own heart rate, thus treating bradyarrhythmia.The ventricular pacing electrode can be placed at multiple locations. Pacing at different locations in the medium and long term may have different effects on the heart function of patients[1]。
Objective: To investigate the effects of right ventricular middle septum (RVMS), right ventricular high septum (RVHS), right ventricular septum (RVS), right ventricular outflow tract (RVOT), right ventricle (RVA) and His bundle (HB) pacemakers on left ventricular function 6 to 36 months after implantation.
Methods PubMed, Embase, Cochrane and Wanfang databases were searched through computer retrieval databases. The retrieval time was up to June 2022. Clinical studies on the effects of pacing at different sites on left ventricular function were collected, and the effects of pacing at different sites on left ejection fraction (LVEF), 6-minute walk test (6MWT), NT proBNP, and QRS duration were compared.
Results: A total of 14 randomized controlled trials were included in our research;All trials were reported postoperative LVEF, 7 trials were reported 6MWT, 5 trials were reported NT proBNP, and 8 trials were reported QRS duration;The results of reticular meta-analysis showed that in terms of LVEF, HB group was superior to other groups in SMD-0.82 (95% CI-1.28, -0.37) in RVS group and SMD-0.77 (95% CI-1.34, -0.19) in RVB group. There was no statistical difference between RVHS group, RVMS group, RVOT group and each group.In 7 articles about the study of 6MWT after pacemaker implantation, the HB group was superior to the RVA group SMD-0.51 (95% CI-0.99, -0.03), and there was no statistical significance between other groups.The SUCRA scores were HB (92.9)>RVS (72.5)>RVHS (30.7)>RVMS (24.6).Five articles related to the study of NT proBNP after pacemaker implantation, HB group was better than RVA group SMD 0.42 (95% CI 0.06,0.79);SMD 0.67 (95% CI 0.13,1.21) in RVS group;SMD 0.69 (95% CI 0.24,1.13) in RVHS group was not significantly different from that in RVMS group.There was no statistical significance between the RVMS group and each group. The HB group was the best, and the SUCRA score was 97.8 for HB.In 8 articles about the study of QRS duration after pacemaker implantation, the HB group was superior to the RVA group SMD1.79 (95% CI 0.32,3.27).There was no statistical significance among other groups.HB group was the best, and the SUCRA score was 85.8.
Conclusion: His bundle pacing is the best in hemodynamics and ventricular synchrony.
Dexmedetomidine versus midazolam for conscious sedation during blind nasotracheal intubation with bispectral index monitoring: a randomized and controlled clinical trial
Authors: Li Zhengyu , Wang Man , Jin Bi , Hou Nina , Yang Heng , Luo Hong , Zhang Yuwei 
Published: October 2023

Abstract
Objective
Despite the rapid progress of tracheal intubation visualization techniques, blind nasotracheal intubation remains a significant approach for difficult airway management, requiring satisfactory conscious sedation. The purpose of this study was to evaluate and compare the efficacy and safety of dexmedetomidine (DEX) and midazolam (MID) for conscious sedation during blind nasotracheal intubation under bispectral index (BIS) monitoring.
Methods
This study included 60 patients undergoing elective oral and maxillofacial surgery who were randomized into two groups: the DEX group (dexmedetomidine, 1.0 µg/kg, continuous infusion for 15 minutes) and the MID group (midazolam, 0.02 mg/kg). Under BIS monitoring, the primary outcome, time of intubation, was recorded. Additionally, changes in vital signs and stress hormone levels were measured before and after intubation. Intraoperative sufentanil consumption was determined, and such parameters as the end-tidal carbon dioxide partial pressure (PETCO2) after intubation as well as pain and satisfaction scores were assessed. Also, postoperatively, the incidence of adverse events associated with nasotracheal intubation was assessed in both groups.
Results
All patients successfully intubated. The DEX group had a shorter intubation time (P < 0.05) when compared to the MID group. In comparison to pre-induction values, BIS, heart rate (HR) and mean arterial pressure (MAP) were significantly decreased after induction of anesthesia in both groups (P < 0.05), with BIS (P < 0.001) and HR (P = 0.001) being significantly lower in the DEX group than the MID group. BIS, MAP and pulse oximeter oxygen saturation (SpO2) immediately after intubation were significantly lower in both groups than before the induction.HR was significantly lower in DEX group than that in the MID group (P < 0.05). The levels of epinephrine (E), and beta-endorphin (β-EP) were significantly reduced at three and fifteen minutes after intubation in the MID group compared to pre-induction values (P < 0.05). Similarly, compared to pre-induction, at three and fifteen minutes after intubation, cortisol (Cor), norepinephrine (NE), E, and β-EP were significantly lower in both groups (P < 0.05). Moreover, the DEX group had lower PETCO2 post-intubation, lower sufentanil consumption, lower postoperative pain scores, and higher patient satisfaction scores (P < 0.05).
Conclusion
Although, using BIS monitoring, both DEX and MID have shown safe and effective conscious sedation for blind nasotracheal intubation, the efficacy of DEX is greater than that of MID.
Trial registration:
This study was registered on the China Clinical Trial Registry website (https://www.chictr.org.cn/index.html) on 26/05/2023 (Registration number: ChiCTR2300071838).
A Novel Pathogenic Tau Conformer Playing Part in Tau Pathology in Human Neurons Upon Aging Stress
Authors: Tofigh Nahid , Agahi Sadaf , Riazi Gholam , Pakdaman Hossein , Moazzam Mahboobeh Ghalamkar , Shahpasand koorosh 
Published: October 2023

Abstract
Alzheimer’s disease (AD), is the most prevalent cause of dementia, with no effective treatment thus far. It is clear that tau protein hyperphosphorylation is the major pathogenic process, leading to neurodegeneration upon AD. It has been previously shown that tau phosphorylation at Thr231 is of crucial importance in tauopathy process. It was reported that pT231-tau in the cis conformation is the early driver of tau pathogenicity in the tauopathy mouse models. In this study, we identified gauche P-tau pathology (a novel P-tau conformer) in human postmortem brain tissue and as well as induced pluripotent stem cell (iPSC) derived neurons from AD patients as the neurotoxic pT231-tau conformer. We observed gauche P-tau levels dramatically increase in neurons under aging stress which disrupts the microtubule network, propagates to other neurons, and ultimately leads to apoptosis and cell death. Moreover, while cis p-tau depletion using respective monoclonal antibody suppressed neurodegeneration in mouse neurons, gauche p-tau elimination using respective monoclonal antibody stopped neurodegeneration in the human AD cultured neurons. Taken these together, we concluded that gauche p-tau is the leading cause of neuronal cell death in human neurons, and the anti gauche p-tau antibody could be introduced as an efficient therapeutic for blocking neurodegeneration upon AD.
Sweat lactate sensor for detecting anaerobic threshold in heart failure: a prospective clinical trial (LacS-001)
Authors: Katsumata Yoshinori , Muramoto Yuki , Ishida Noriyuki , Takemura Ryo , Nagashima Kengo , Ikoma Takenori , Kawamatsu Naoto , Araki Masaru , Goda Ayumi , Okawara Hiroki , Sawada Tomonori , Ichihara　Kawakubo Yumiko , Hattori Osamu , Yamaoka Koki , Seki Yuta , Ryuzaki Toshinobu , Ikura Hidehiko , Nakashima Daisuke , Nagura Takeo , Nakamura Masaya , Sato Kazuki , Shiraishi Yasuyuki 
Published: October 2023

Abstract

Background
A simple method for determining the anaerobic threshold in patients with heart failure (HF) is needed. This prospective clinical trial (LacS-001) investigated the safety of a sweat lactate-monitoring sensor and the correlation between lactate threshold in sweat (sLT) and ventilatory threshold (VT).
Methods
We recruited 50 patients with HF and New York Heart Association functional classification I–II (mean age: 63.5 years, interquartile range: 58.0–72.0 years). Incremental exercise tests were conducted while monitoring sweat lactate levels using our sensor. sLT was defined as the first steep increase in lactate levels from baseline. Primary outcome measures were a correlation coefficient of ≥ 0.6 between sLT and VT, similarities as assessed by the Bland–Altman analysis, and standard deviation of the difference within 15 W.
Results
A correlation coefficient of 0.651 (95% confidence interval, 0.391–0.815) was achieved in 32/50 cases. The difference between sLT and VT was − 4.9 ± 15.0 W. No comparative error was noted in the Bland–Altman plot. No device-related adverse events were reported among the registered patients.
Conclusions
Our sweat lactate sensor is safe and accurate for detecting VT in patients with HF in clinical settings, thereby offering valuable additional information for treatment.
Clinical characteristics and prognostic factors of patients with intraocular foreign bodies from a Tertiary Eye Center in North China
Authors: Xing XiaoLi , Liu Fang , Qi Yan , Li Jun , Yu Bin , Wan Lei 
Published: October 2023

Abstract
Background
This study aims to describe the epidemiology and clinical features of patients with intraocular foreign bodies (IOFBs) and analyze the prognostic factors influencing final vision.
Methods
We retrospectively reviewed medical records of 159 patients (159 eyes) with IOFBs admitted to Qingdao Eye Hospital of Shandong First Medical University between January 1, 2014, and December 31, 2021. Demographic characteristics, clinical features, and prognostic factors were analyzed.
Results
This study analyzed 159 patients (159 eyes) with IOFBs. The mean age of the patients was 41.58 ± 11.97 years, with 151 (95.0%) being males. The most common age group was 40–49 years. Based on discharge and follow-up results, IOFB removal was performed through pars plana incision in 105 (67.9%) eyes, corneoscleral limbus incision in 24 (15.1%) eyes, and original wound in 27 (17.0%) eyes. Of these, 44 eyes underwent IOFB removal without vitrectomy, while 55 eyes were treated with silicone oil. Post-vitrectomy, three cases showed secondary macular membrane, five cases exhibited retinal detachment, and enucleation was necessary in three cases. The final best corrected visual acuity (BCVA, logMAR) was 1.65 ± 0.87, significantly better than preoperative visual acuity of 1.06 ± 0.88 (t = 8.21, p < 0.01). Multi-factor logistic regression analysis indicated that wound length, IOFB size, initial presenting visual acuity (VA), and macular lesions were prognostic factors for postoperative vision after intraocular foreign body surgery (p < 0.05).
Conclusions
In a tertiary eye center in northern China, IOFBs predominantly affected the working-age group, particularly males. Factors such as wound length, IOFB size, initial presenting VA, and macular lesions might impact the final visual outcome.
A signal-on electrochemical aptasensor for rapid detection of methylamphetamine based on competition with complementary DNA
Authors: Chang Wenzhuo Chang , Zheng Zhixiang , Ma Yongjun , Du Yongling , Shi Xuezhao , Wang Chunming 
Published: October 2023

Abstract
A simple and rapid electrochemical sensing method with high sensitivity and specificity of aptamers was developed for the detection of methylamphetamine (MAMP).A short anti-MAMP thiolated aptamer (Apt) with a methylene blue (MB) probe at 3’-end was immobilized on the surface of a gold electrode (MB-Apt-S/GE). The electrochemical signal appeared when MAMP presenting in the sample solution competed with cDNA for binding with MB-Apt-S. Under optimized conditions, the liner range of this signal-on electrochemical aptasensor for the detection of MAMP achieved from 1.0 to 10.0 nmol/L and 10.0 to 400 nmol/L. Satisfactory spiked recoveries of saliva and urine were also obtained. In this method, only 5 minutes were needed to incubate before the square wave voltammetry (SWV) analysis, which was much more rapid than other electrochemical sensors, leading to a bright and broad prospect for the detection of MAMP in biological sample. This method can be used for on-site rapid detection on special occasions, such as drug driving scenes, entertainment venues suspected of drug use, etc.