bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutrition self-efficacy intervention to improve nutritional status of Iranian older adults
Authors: Tavakoly Sany Seyedeh Belin , Ahangari Hamideh , Rasoulifar Amir , Salimi Mitra , Jamali Jamshid , Tehrani Hadi 
Published: February 2024

Abstract
Objectives
Older adults are a vulnerable group that is at risk of poor nutritional status, which can lead to disease and increase their healthcare costs. Our study aimed to investigate the impact of a self-efficacy intervention on the nutritional status of older adults.

Methods
A controlled before and after study was conducted on 110 older adults in the Mashhad, Iran, from 2020 to 2022. Participants were randomly allocated to the intervention (n = 55) and control groups (n = 55). Participants in the intervention group received educational training that was based on the self-efficacy theory. The control group received the routine care. Data collection tools included demographic information questionnaire, Mini Nutritional Assessment Questionnaire, and standard self-efficacy questionnaire. The questionnaires were completed at baseline (before intervention), instantly after the intervention, and at 3-months follow-up by participants in both groups. Data were analyzed using SPSS version 25 and the significance level was considered less than 0.05.

Results
The Mean of nutritional status in the intervention group, at the baseline, immediately after intervention and 3 months of follow-up were 25.1 ± 2.3, 28.3 ± 5.2 and 27.6 ± 6., respectively. This increase was significant (p < 0.001). Our findings revealed that self-efficacy among participants in the intervention group significantly changed (P < 0.001) across time from baseline through follow-up. There was no significant difference in the mean of self-efficacy and nutritional status in the control group during the study period (P > 0.05).

Conclusion
This current study provided a basis to examine in the effectiveness of such intervention using a properly powered randomized controlled study. Therefore, it can be concluded that self-efficacy interventions are a promising approach to improving the nutritional behaviors of the older adults.
Trial registration: IRCT20160619028529N9.
Understanding immune-mediated cobalt/chromium allergy to orthopaedic implants: a meta-synthetic review
Authors: Chen Arnold , Kurmis Andrew P. 
Published: February 2024

Abstract
Background
The frequency of primary joint replacement surgery continues to increase worldwide. While largely considered biologically inert entities, an increasing body of evidence continues to validate a not insignificant incidence of allergic reactions to such implants. Little previous work has explored genuinely immune-mediated reactivity in this context. In the absence of a contemporary published summary on the topic, this paper explored the current state of understanding of cobalt/chromium allergy and proposes a patient management algorithm whereby such immune reactions are clinically suggested.

Methods
A structured, systematic literature review was performed by following PRISMA search principles to provide an updated review of this area.

Results
Thirty-six topic-related articles were identified, the majority reflecting lower tiers of scientific evidence with a lack of homogeneous quantitative data to facilitate valid cohort comparisons. Largely, the available literature represented small case series’ or expert opinions.

Conclusions
Despite increasing clinical awareness and acknowledgement of true allergy to joint replacement components, this review highlighted that the evidence base underpinning the diagnosis and management of such patients is limited. Both patient-reported metal allergy or skin patch testing are grossly unreliable methods and show almost no correlation with true immune reactivity. Recent studies suggested a potential role for patient-specific in vitro cellular activation testing and/or targeted genetic testing when cobalt/chromium allergy is clinically suspected. However, while likely representing the contemporary “best available” approaches both can be costly undertakings, are not yet universally available, and still require broader validation in non-research settings before wider uptake can be championed.
Phase II study of pembrolizumab in combination with radiation with or without olaparib in localized high-risk prostate cancer.
Authors: Myint Zin , St. Clair William H , Strup Stephen , Hensley Patrick J. , Yan Donglin , Tward Jonathan David , Maughan Benjamin L. 
Published: February 2024

TPS351 Background: Definitive radiation therapy (DRT) combined with androgen deprivation therapy (ADT) remains the standard of care in patients with high-risk prostate cancer (HRPC) who do not want surgery. However, up to 50% experience biochemical recurrence (BCR) within 5 years. A phase 3 NCIC group reported the 10-year biochemical recurrence free survival was 63% in ADT plus DRT vs. 27% in ADT alone. There is an urgent need for effective novel combination strategies. We hypothesize combined immune sensitizing effects of PARPi and radiation will result in significant activity of immunotherapy in men with HRPC. Methods: This is a multicenter phase II randomized study to assess biochemical response rates, safety and tolerability of combined therapy in pts with localized HRPC who elected for concurrent DRT. A total of 64 pts will be randomized 1:1 to receive either pembrolizumab (P) combined with olaparib or single agent P in addition to the standard of care ADT with DRT. Hypofractionated IMRT (2.4 to 4 Gy per fraction over 4-6 weeks) will be delivered and all pts will receive adjuvant P for one year and ADT for at least 18 months. All pts will undergo germline testing. Key eligible criteria include biopsy confirmed prostate adenocarcinoma who meets at least one of the four high-risk features: 1) clinical T3a, T3b or T4, 2) N1, 3) Gleason grade group 4 or 5, and 4) PSA >20 ng/ml. Patients with less than 2 cm pelvic nodes and received ADT therapy within 3months prior to study enrollment are allowed. PSA >150 ng/ml and patients with distant metastases will be excluded. The primary endpoint is to assess the proportion of patients who achieve a PSA nadir level of ≤ 0.06 ng/ml within six months after completion of radiation therapy in each arm. The secondary objectives include safety/tolerability, BCR and metastasis-free survival at 3 years. BCR is defined by the Phoenix definition. The study is designed to detect a 15% improvement in PSA nadir ≤ 0.06 ng/mL within 6 months after completion of the combined therapy versus historical control group data Geara FB et al., 2017. Enrollment began in August 2023. Clinical trial information: NCT05568550 .
Continuous PEGasparaginase Dosing Reduces Hypersensitivity Reactions in Pediatric ALL: A Dutch Childhood Oncology Group ALL11 Randomized Trial
Authors: van der Sluis Inge M. , Brigitha Leiah J. , Fiocco Marta , de Groot-Kruseman Hester A. , Bierings Marc , van den Bos Cor , de Haas Valerie , Hoogerbrugge Peter M. , Tissing Wim J.E. , Veening Margreet A. , Pieters Rob 
Published: February 2024

PURPOSE The primary objective of this randomized study was to determine whether a continuous dosing schedule (without the asparaginase-free interval) would result in less hypersensitivity reactions to PEGasparaginase (PEGasp) compared with the standard noncontinuous dosing schedule. METHODS Eight hundred eighteen patients (age 1-18 years) with ALL were enrolled in the Dutch Childhood Oncology Group-ALL11 protocol and received PEGasp. Three hundred twelve patients stratified in the medium-risk arm were randomly assigned to receive 14 individualized PEGasp doses once every two weeks in either a noncontinuous or continuous schedule after the first three doses in induction (EudraCT: 2012-000067-25). Hypersensitivity reactions were defined as allergies, allergic-like reactions, and silent inactivation. Secondary end points were other asparaginase-related toxicities, asparaginase activity and antibody levels, and outcome. RESULTS During induction, 27 of 818 patients (3.3%) experienced hypersensitivity reactions. After random assignment, 4 of 155 (2.6%) in the continuous treatment arm versus 17 of 157 (10.8%) patients in the noncontinuous treatment arm had hypersensitivity reactions ( P < .01), of which two (1.3%) versus 13 (8.3%) were inactivating reactions ( P < .01). The occurrence of inactivating hypersensitivity reactions was seven times lower in the continuous arm (odds ratio, 0.15 [0.032-0.653]). In addition, antibody levels were significantly lower in the continuous arm ( P < .01). With exception of a lower incidence of increased amylase in the continuous arm, there were no significant differences in total number of asparaginase-associated toxicities between arms. However, the timing of the toxicities was associated with the timing of the asparaginase administrations. No difference in 5-year cumulative incidence of relapse, death, or disease-free survival was found between both treatment arms. CONCLUSION A continuous dosing schedule of PEGasp is an effective approach to prevent antibody formation and inactivating hypersensitivity reactions. The continuous PEGasp schedule did not increase toxicity and did not affect the efficacy of the therapy.
Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project
Authors: MARMOL-PEREZ ANDRES , MIGUELES JAIRO H. , UBAGO-GUISADO ESTHER , GIL-COSANO JOSE J. , RODRIGUEZ-SOLANA ANDREA , REDONDO-TÉBAR ANDRÉS , LLORENTE-CANTARERO FRANCISCO J. , LABAYEN IDOIA , ORTEGA FRANCISCO B. , RUIZ JONATAN R. , GRACIA-MARCO LUIS 
Published: February 2024

ABSTRACT

Purpose
We aimed to examine the associations of 24-h movement behaviors (moderate to vigorous physical activity [MVPA], light physical activity [LPA], sedentary behavior [SB], and sleep) with age-, sex-, and race-specific areal bone mineral density (aBMD) z-score parameters at clinical sites in young pediatric cancer survivors.

Methods
This cross-sectional multicenter study was carried out within the iBoneFIT framework in which 116 young pediatric cancer survivors (12.1 ± 3.3 yr old; 42% female) were recruited. We obtained anthropometric and body composition data (i.e., body mass, stature, body mass index, and region-specific lean mass), time spent in movement behaviors over at least seven consecutive 24-h periods (wGT3x-BT accelerometer, ActiGraph), and aBMD z-score parameters (age-, sex-, and race-specific total at the body, total hip, femoral neck and lumbar spine). Survivors were classified according to somatic maturity (pre or peri/postpubertal depending on the estimated years from peak height velocity). The adjusted models’ coefficients were used to predict the effect of reallocating time proportionally across behaviors on the outcomes.

Results
In prepubertal young pediatric cancer survivors, reallocating time to MVPA from LPA, SB, and sleep was significantly associated with higher aBMD at total body (B = 1.765, P = 0.005), total hip (B = 1.709, P = 0.003), and lumbar spine (B = 2.093, P = 0.001). In peri/postpubertal survivors, reallocating time to LPA from MVPA, SB, and sleep was significantly associated with higher aBMD at all sites (B = 2.090 to 2.609, P = 0.003 to 0.038). Reallocating time to SB from MVPA or LPA was significantly associated with lower aBMD at most sites in prepubertal and peri/postpubertal survivors, respectively. Finally, reallocating time to sleep from MVPA, LPA, and SB was significantly associated with lower aBMD at total body (B = −2.572, P = 0.036) and total hip (B = −3.371, P = 0.015).

Conclusions
These findings suggest that every move counts and underline the benefits of increasing MVPA or LPA, when low MVPA levels are present, for bone regeneration after pediatric cancer treatment completion.
Ο φθοροποιός καταναλωτισμός και η ελληνική κρίση
Authors: Λάλλας Δημήτρης , Ζαρίκος Ιάσωνας , Σωτηροπούλου Μαρία (Μάνια) 
Published: February 2024

Στο άρθρο αυτό αναδεικνύουμε τον τρόπο νοηματοδότησης του καταναλωτισμού και της προβληματοποίησης της σχέσης του με την ελληνική κρίση, αναλύοντας τη σχετική αρθρογραφία στο έντυπο της Καθημερινής της Κυριακής κατά την περίοδο 2010-2016. Αξιοποιώντας τη μεθοδολογία της Θεματικής Ανάλυσης, παρουσιάζουμε τα βασικά θεματικά μοτίβα μέσα από τα οποία αναδεικνύονται συγκεκριμένες πολιτικές νοηματοδότησης του καταναλωτισμού και της πολυδιάστατης (όχι μόνο δημοσιονομικής) ελληνικής κρίσης ως φαινομένων στενά συνυφασμένων. Η ανάδειξη του καταναλωτισμού ως φθοροποιού και παθογενούς ήθους σε κεντρικό θεματικό μοτίβο υποδεικνύει πολιτικές νοηματοδότησης του καταναλωτισμού ως αιτίου, συμπτώματος και ως παράγοντα επίτασης της πολυδιάστατης κρίσης του ελληνικού κοινωνικού σχηματισμού. Πρόκειται για πολιτικές νοήματος μαζικής απεύθυνσης και φαίνεται ότι εγγράφονται στην ευρύτερη φιλελεύθερη προοπτική επιχειρώντας να ερμηνεύσουν την ελληνική κρίση μέσα από το αναλυτικό πρίσμα της κατανάλωσης και, κυρίως, του καταναλωτισμού.
Diagnostic value of radiological examination methods in the detection of odontogenic sinusitis
Authors: Storozhchuk Yuliia , Kundina Viktoriia 
Published: February 2024

It is emphasized that odontogenic sinusitis frequency for at least 9–11% of the total number of inflammatory diseases of the maxillofacial area, and the frequency of their complications ranges from 30% to 50%. Emphasis is placed on the fact that a frequent cause of the development of odontogenic sinusitis is errors in the endodontic treatment of teeth and errors in dental implantation, which is accompanied by the use of tools for processing root canals (root needles, drills, canal fillers, pulp extractors), as well as filling material and an implant behind the apex tooth root into the sinus cavity.
Radiological research methods play a leading role in the diagnosis of odontogenic sinusitis. Traditionally, for the evaluation of paranasal sinuses, radiography in the nasolabial projection, inspection radiographs of the skull in direct and lateral projections are used. The advantages and disadvantages of multispiral computed tomography (MCT), magnetic resonance imaging (MRI) and cone beam computed tomography (CBCT) are given separately. For a group of 130 patients, the results of the diagnostic informativeness of radiological examination methods in the detection of odontogenic sinusitis are given.
The obtained results allow to conclude that in all cases computer tomography (MCT or CBCT) made it possible to accurately diagnose the form of the disease, determine the extent of sinus damage, assess the condition of the lower bone wall of the sinus (reveal a violation of its integrity and report a tooth socket with a sinus), to determine the center of inflammation in the periodontium, as well as to detect the presence of foreign bodies in the maxillary sinus. At the same time, MCT and CBCT data were fully compared with each other, surpassed traditional radiological methods in terms of diagnostic informativeness and had such advantages as the absence of superposition, high contrast resolution, and the possibility of obtaining higher-quality image reconstructions in different planes.
The aim of study. To analyze the diagnostic value of radiological examination methods in the detection of odontogenic sinusitis.Material and methods: We examined 130 patients in the period from 2022 to 2023. X-ray examinations were performed on a Planmeca ProMax 3D cone beam computed tomography scanner and MCT.Results: Regarding the data of СBCT, it is possible to specify the localization of the foreign body and its connection with the odontogenic factor with high probability. It is worth noting that these sinusitis belong to the iatrogenic group of diseases.Conclusions: CT methods (MCT or CBCT) are a necessary component of the complex diagnosis of odontogenic sinusitis.
Cutaneous manifestations associated with COVID-19: summary of current knowledge
Authors: Jung Magdalena , Woźniak Kinga , Jung Maximilian , Sysło Oliwia , Hedesz Patryk , Gardian-Baj Monika , Szczerbiak Alicja , Jędral Krystian , Żuk-Łapan Aleksandra , Doryń Aleksandra 
Published: February 2024

Introduction and purpose: Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had been spreading rapidly throughout the world, mainly affecting respiratory system. Except pulmonary symptoms, skin lesions might also occur. The precise percentage of patients with confirmed COVID-19 who presented cutaneous manifestations is still unknown (0.2% - 20.4%). Part of the skin lesions might be drug-induced.
Brief description of the state of knowledge: Cutaneous manifestations in the course of the coronavirus disease could be divided into six main groups: maculopapular rash, urticarial lesions, chilblain‐like lesions, vesicular eruptions, petechial/purpuric lesions and livedoid lesions. The most common skin lesions are maculopapular eruptions (47%). Trunk is the most affected location, whereas pruritus is the most frequent additional symptom among patients with skin lesions associated with coronavirus disease. These lesions appear mainly in elderly patients except pseudo chilblains which are present among children and young adults with SARS-Cov-2 infection. The majority of cutaneous manifestations occur after COVID-19 systemic symptoms, but the appearance of vesicular lesions before the respiratory signs was also reported. Cutaneous manifestations resolved spontaneously at different times, ranging from a few days to 2-4 weeks. Moreover, patients with severe course of COVID-19 with maculopapular rash have better prognosis (2% mortality rate) in comparison to patients who developed livedoid lesions in course of the coronavirus disease (10% mortality rate).
Summary: Pseudo-chilblains and vesicular lesions are the most specific cutaneous manifestations of coronavirus disease. Healthcare professionals should pay attention to patients who present skin symptoms in the course of COVID-19. Cutaneous manifestations can facilitate the doctor the diagnosis and even estimate the severity of coronavirus disease.
Periodontal health status in systemic sclerosis patients: Systematic review and meta-analysis
Authors: Sredojevic Stefan , Colak Dejana , Gaspersic Rok , Pavlov Dolijanovic Slavica , Jakovljevic Aleksandar , Nikolic-Jakoba Natasa 
Published: February 2024

Objective
The present systematic review and meta-analysis aimed to evaluate the periodontal health of systemic sclerosis patients compared with non-systemic sclerosis controls.

Materials and methods
Online databases were searched for eligible studies on February 24, 2023. The primary outcomes of interest in systemic sclerosis patients and controls included the clinical attachment level, periodontal probing depth, recession depth, plaque index, bleeding on probing score, gingival index, number of teeth with periodontitis, prevalence of periodontitis and gingivitis, and extent and severity of periodontitis.

Results
Fourteen studies met inclusion criteria and were incorporated in the qualitative and quantitative analysis. In comparison with the controls, systemic sclerosis patients had a higher prevalence of periodontitis (OR = 7.63 (1.74–33.50), p = 0.04, I2 = 69%), including more severe forms of periodontitis (OR = 6.68 (3.39–13.15), p = 0.85, I2 = 0%), as well as higher periodontal probing depth ((0.88 (0.45–1.31), p = 0.02, I2 = 99%)), clinical attachment level (1.22 (0.8–1.64), p = 0.003, I2 = 98%), and plaque presence (0.83 (0.13–1.53), p = 0.03, I2 = 96%). There was no statistically significant difference in gingival inflammation (1.14 (0.07–2.21), p = 0.04, I2 = 98%).

Conclusions
The systematic review and the meta-analysis showed that systemic sclerosis patients suffer from worse periodontal health than non-systemic sclerosis individuals.
Modelling HIV/AIDS epidemiological complexity: A scoping review of Agent-Based Models and their application
Authors: Anderle Rodrigo Volmir , de Oliveira Robson Bruniera , Rubio Felipe Alves , Macinko James , Dourado Ines , Rasella Davide 
Published: February 2024

Objective
To end the AIDS epidemic by 2030, despite the increasing poverty and inequalities, policies should be designed to deal with population heterogeneity and environmental changes. Bottom-up designs, such as the Agent-Based Model (ABM), can model these features, dealing with such complexity. HIV/AIDS has a complex dynamic of structural factors, risk behaviors, biomedical characteristics and interventions. All embedded in unequal, stigmatized and heterogeneous social structure. To understand how ABMs can model this complexity, we performed a scoping review of HIV applications, highlighting their potentialities.

Methods
We searched on PubMed, Web of Science, and Scopus repositories following the PRISMA extension for scoping reviews. Our inclusion criteria were HIV/AIDS studies with an ABM application. We identified the main articles using a local co-citation analysis and categorized the overall literature aims, (sub)populations, regions, and if the papers declared the use of ODD protocol and limitations.

Results
We found 154 articles. We identified eleven main papers, and discussed them using the overall category results. Most studies model Transmission Dynamics (37/154), about Men who have sex with Men (MSM) (41/154), or individuals living in the US or South Africa (84/154). Recent studies applied ABM to model PrEP interventions (17/154) and Racial Disparities (12/154). Only six papers declared the use of ODD Protocol (6/154), and 34/154 didn’t mention the study limitations.

Conclusions
While ABM is among the most sophisticated techniques available to model HIV/AIDS complexity. Their applications are still restricted to some realities. However, researchers are challenged to think about social structure due model characteristics, the inclusion of these features is still restricted to case-specific. Data and computational power availability can enhance this feature providing insightful results.