bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection performance and prognostic value of initial bone marrow involvement in diffuse large B-cell lymphoma: a single centre 18F-FDG PET/CT and bone marrow biopsy evaluation study
Authors: Doma Andrej , Zevnik Katarina , Studen Andrej , Prevodnik Veronika Kloboves , Gasljevic Gorana , Novakovic Barbara Jezersek 
Published: February 2024

Abstract

Background
Detection of bone marrow involvement (BMI) in diffuse large B-cell lymphoma (DLBCL) typically relies on invasive bone marrow biopsy (BMB) that faces procedure limitations, while 18F-FDG PET/CT imaging offers a noninvasive alternative. The present study assesses the performance of 18F-FDG PET/CT in DLBCL BMI detection, its agreement with BMB, and the impact of BMI on survival outcomes.

Patients and methods
This retrospective study analyzes baseline 18F-FDG PET/CT and BMB findings in145 stage II–IV DLBCL patients, evaluating both performance of the two diagnostic procedures and the impact of BMI on survival.

Results
DLBCL BMI was detected in 38 patients (26.2%) using PET/CT and in 18 patients (12.4%) using BMB. Concordant results were seen in 79.3% of patients, with 20.7% showing discordant results. Combining PET/CT and BMB data, we identified 29.7% of patients with BMI. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT for detecting DLBCL BMI were 88.4%, 100%, 100%, 95.3%, and 96.5%, respectively, while BMB showed lower sensitivity (41.9%) and NPV (46.8%). The median overall survival (OS) was not reached in any gender subgroup, with 5-year OS rates of 82% (total), 84% (female), and 80% (male) (p = 0.461), while different International Prognostic Index (IPI) groups exhibited varied 5-year OS rates: 94% for low risk (LR), 91% for low-intermediate risk (LIR), 84% for high-intermediate risk (HIR), and 65% for high risk (HR) (p = 0.0027). Bone marrow involvement did not impact OS significantly (p = 0.979).

Conclusions

18F-FDG PET/CT demonstrated superior diagnostic accuracy compared to BMB. While other studies reported poorer overall and BMI 5-year OS in DLBCL, our findings demonstrated favourable survival data.
RAD54B promotes gastric cancer cell migration and angiogenesis via the Wnt/β-catenin pathway
Authors: Li Jianchao , Geng Hui , Li Xin , Zou Shenshan , Xu Xintao 
Published: February 2024

Abstract

Background
Gastric cancer is an epidemic malignancy that is commonly diagnosed at the late stage. Evidence has elucidated that RAD54B exerts a crucial role in the progress of various tumors, but its specific role and mechanism in gastric cancer remain gloomy.

Materials and methods
The level of RAD54B was detected by western blot. RAD54B expression was downregulated or upregulated in both MKN45 and AGS cells by the transfection of shRAD54B or overexpression plasmid, respectively. The role of RAD54B in the growth, migration, invasion and tube formation of gastric cancer was evaluated by Edu, colony formation, transwell and tube formation assays. In addition, the molecular mechanism of RAD54B in gastric cancer was also determined by western blot. Moreover, in vivo experiment was conducted in xenografted mice.

Results
The expression of RAD54B was discovered to be upregulated in gastric cancer based on the ATGC and GEPIA databases, which was also confirmed in gastric cancer cell lines. Moreover, overexpression of RAD54B enhanced the growth, migration, invasion, tube formation and Wnt/β-catenin signaling axis in AGS and MKN45 cells. As expected, knockdown of RAD54B in AGS and MKN45 cells reversed these promotions. More importantly, in vivo assay also verified that RAD54B accelerated the growth of gastric cancer and Wnt/β-catenin signaling pathway.

Conclusions
Both loss-of-function and gain-of-function assays demonstrated that RAD54B facilitated gastric cancer cell progress and angiogenesis through the Wnt/β-catenin axis.
Role of diffusion-weighted imaging in response prediction and evaluation after high dose rate brachytherapy in patients with colorectal liver metastases
Authors: Karim Salma , Seidensticker Ricarda , Seidensticker Max , Ricke Jens , Schinner Regina , Treitl Karla , Rübenthaler Johannes , Ingenerf Maria , Schmid-Tannwald Christine 
Published: February 2024

Abstract

Background
The aim of the study was to assess the role of diffusion-weighted imaging (DWI) to evaluate treatment response in patients with liver metastases of colorectal cancer.

Patients and methods
In this retrospective, observational cohort study, we included 19 patients with 18 responding metastases (R-Mets; follow-up at least one year) and 11 non-responding metastases (NR-Mets; local tumor recurrence within one year) who were treated with high-dose-rate brachytherapy (HDR-BT) and underwent pre- and post-interventional MRI. DWI (qualitatively, mean apparent diffusion coefficient [ADCmean], ADCmin, intraindividual change of ADCmean and ADCmin) were evaluated and compared between pre-interventional MRI, first follow-up after 3 months and second follow-up at the time of the local tumor recurrence (in NR-Mets, mean: 284 ± 122 d) or after 12 months (in R-Mets, mean: 387+/−64 d). Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) for detection of local tumor recurrence were calculated on second follow up, evaluating (1) DWI images only, and (2) DWI with Gd-enhanced T1-weighted images on hepatobiliary phase (contrast-enhanced [CE] T1-weight [T1w] hepatobiliary phase [hb])

Results
ADCmean significantly increased 3 months after HDR-BT in both groups (R-Mets: 1.48 ± 0.44 and NR-Mets: 1.49 ± 0.19 x 10−3 mm2;/s, p < 0.0001 and p = 0.01), however, intraindividual change of ADCmean (175% vs.127%, p = 0.03) and ADCmin values (0.44 ± 0.24 to 0.82 ± 0.58 x 10−3 mm2/s) significantly increased only in R-Mets (p < 0.0001 and p < 0.001). ADCmin was significant higher in R-Mets compared to NR-Mets on first follow-up (p = 0.04). Sensitivity (1 vs. 0.72), specificity (0.94 vs. 0.72), PPV (0.91 vs. 0.61) and NPV (1 vs. 0.81) could be improved by combining DWI with CE T1w hb compared to DWI only.

Conclusions
DW-MRI seems to be helpful in the qualitative and quantitative evaluation of treatment response after HDR-BT of colorectal metastases in the liver.
Low Interest Rates and Uncreative Destruction in the Office Market
Authors: Olszewski Krzysztof , Trojanowski Dariusz , Łaszek Jacek 
Published: February 2024

Abstract
Low interest rates were introduced in the global economy to support the weak economic growth that followed the global financial crisis. In the real estate sector, low interest rates usually lead to a boom in investment and prices. This boom, however, is not spread throughout the economy, but rather concentrated in major cities. We demonstrate this phenomenon on the example of the office market in Warsaw (Poland). While it would be beneficial for the Polish economy to develop office space in smaller cities that have an insufficient supply of modern office space, investors have focused mainly on the capital. This has not only led to an increase in the cost of building land and construction, but has also pushed some relatively new existing office buildings off the market. We call such behaviour uncreative destruction and explain why it was possible.
Hydroxychloroquine Induced Cardiotoxicity: A Case Series
Authors: Schneider Artur , Sadhana Jonna , Menindez Maximiliano Diaz , Jeevaratnam Suren , Balistreri Lisa , Thomas Colleen , Chirila Razvan , Berianu Florentina 
Published: February 2024

Abstract
Hydroxychloroquine (HCQ) induced cardiotoxicity is a rare diagnosis and is often associated with chronic use of the medication. It has been shown that chronic HCQ use is associated with a drug-induced cardiomyopathy mainly driven by acquired lysosomal storage defects leading to hypertrophy and conduction abnormalities. As the only proven treatment is the discontinuation of the offending agent, prompt recognition is required to avoid further exposure to the drug and potential progression of disease. History, physical examination and advanced imaging modalities are useful diagnostic tools, but more invasive testing with an endomyocardial biopsy is required for definitive diagnosis. We present a descriptive case series of ten patients that were diagnosed with biopsy proven HCQ cardiotoxicity.
The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient
Authors: Virgolici Bogdana , Dobre Maria Zinaida , Lixandru Daniela , Petcu Laura , Picu Ariana , Ionescu-Târgovişte Constantin , Greabu Maria , Bacanu Elena Violeta 
Published: February 2024

Abstract

Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte Chemoattractant Protein-1) and TNF-α (tumour necrosis factor) as inflammatory markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in type 2 diabetic patients. The aim of this study was to evaluate the specific biological picture of type 2 diabetic patients that also associate higher GGT activity.

Methods. Eighty-five type 2 diabetes, aged 40–70 years with a duration of diabetes less than 6 years without infections, epilepsy, chronic liver or cardiac diseases, without alcohol consumption (>20 g/day) were divided in two subgroups, those with normal and those with high abnormal GGT.

Results. The diabetic patients with high GGT (n=31) had dysglycaemia, dyslipidemia, higher inflammatory markers (CRP, TNF-α, MCP-1) and endothelial dysfunction (high leptin and sICAM). sICAM, serum MCP-1 and TNF-α levels had significant correlations with GGT activity (r= 0.38, r=0.30 and 0.26 respectively, p<0.05).

Conclusion. This study underlines that in non-alcoholic diabetic patients, with a duration of the metabolic disease less than 6 years, sICAM, serum MCP-1 and TNF-α might play an important role in dysmetabolism, and higher level for GGT represents the „red flag” for this condition.
An Explication of Anthropogenic Climate Change in Anuradha Roy’s An Atlas of Impossible Longing
Authors: Augustus Karen , Gnanadurai Christopher 
Published: February 2024

Objective: Climate change is an alarming concept prevailing as a threat to human existence. The paper aims to emphasise on climate change, a concern for environment portrayed in Anuradha Roy’s novel An Atlas of Impossible Longing (2008). Extending this hypothesis, the paper aims to scrutinize the changes happening in the climate and environment in the novel during the partition period in India.

Method: The researchers have used qualitative research and to bring this research with a descriptive approach. However, the researcher lays out the study under the main theory of ecocriticism and narrows it down to the specific concept of ‘Climate change’.

Result: The novel An Atlas of Impossible Longing (2008) is set on the outskirts of West Bengal, which is located in the northern part of India. A widower character in the novel is finding it difficult to get attached to his motherless daughter who is quite close to an orphan boy named Mukunda, adopted by the family. The characters in the novel live in tune with nature and find certain difficulties to continue their lifestyle because of climate change.

Conclusion: In the explication on the concept of ‘climate change’ the researcher examines the relevant concepts like anthropocentric and anthropogenic which might be the cause of climate change. The main scope of this paper is to prioritize the concept of climate change for sustaining nature.
Single Mothers’ Perspectives on Social Welfare Programs for Women in Tamil Nadu
Authors: Dharani Muthu Kamarajan , Balamurugan Janarthanan 
Published: February 2024

Objective: The study aims to examine the awareness of assistance policies and schemes for women among single mothers. Therefore, the current study concentrates on demographic profile of single mothers and to examine the awareness, accessibility, and effectiveness of schemes and welfare policies among rural single mothers.

Methods: The research employed a quantitative and descriptive research design to examine 230 rural single mothers from the Gudiyattam Division, Vellore District. The responses are gathered using semi-structured questionnaires and interview schedules, and the data are analysed using the Statistical Package for the Social Sciences (SPSS).

Result and Conclusion: The study rejects the hypothesis because education plays a significant role in shaping an individual's pursuit of knowledge about the various welfare schemes instituted specifically for rural women. As a result, women must be educated at the grassroots level about these welfare schemes and policies for better survival in society, and policymakers must implement steps to raise the level of education for women in the nation.

Implications of the research: Awareness of the scheme is a crucial metric for determining the success of any programme. Even the utilisation rate of the programme is extremely low. Therefore, researching large samples of single mothers is necessary to identify their level of awareness and to benefit from the schemes.
Disain CAD Mekanisme Paralel Tiga Derajat Translasi Murni Dengan Rantai Kinematik Kombinasi Sambungan Revolut dan Prismatik
Authors: Huda Syamsul , Bur Mulyadi , Aris Zul Arifin 
Published: February 2024

In this study it was discussed kinematic design of a 3-RRRPP translational parallel mechanism. The design was carried out by using simulation performed using CAD software. Motion platform was analyzed based on screw and reciprocal screw theory. The evaluation mechanism performance was determined by introducing the stages of research in the form to determine mechanism parts such as base, links, and platform. The work was continued with the assembly process of each part. Furthermore, kinematic response represented by displacement of platform positions was figured out by a CAD simulation. Based on the results of the simulation, it was successfully designed the mechanism performing the translational motion of the Platform.
E-LIXO ELETRÔNICO DE INFORMÁTICA EDUCAR PARA O DESCARTE CORRETO
Authors: Hayashi Arthur Yukio , De Ré Angelita Maria , Michelon Gisane Aparecida , Prestes Marcus Vinicyus Pires 
Published: February 2024

O consumo desenfreado de equipamentos eletrônicos incentivado pela obsolescência programada desses produtos gera um acúmulo de lixo eletrônico crescente no mundo todo. Os computadores constituem a base do avanço da tecnologia e, por serem itens que são substituídos muito facilmente, exigem um cuidado maior. Pois, muitas vezes, computadores inteiros são descartados por conta de uma única peça defeituosa que impossibilita o seu funcionamento. Nesse contexto, o programa E-Lixo de Informática surge como uma alternativa extensionista, que junto à comunidade da UNICENTRO, realiza um processo que envolve desde a coleta até a doação de computadores e/ou peças após o conserto dos mesmos. Além de estabelecer uma relação com o ensino, pois a participação dos acadêmicos do curso de Ciência da Computação permite a esses complementarem de forma prática a formação acadêmica. Nos anos de 2022 e 2023 o programa realizou a doação para a comunidade universitária da UNICENTRO de desktops, notebooks, periféricos e componentes. Além disso foram doados também para projetos sociais e ações comunitárias.
ASISTENSI PENGGUNAAN E-FILING DALAM PELAPORAN SPT TAHUNAN BAGI WAJIB PAJAK ORANG PRIBADI DI KPP PRATAMA KARAWANG
Authors: Nurhidayat Intan , Mahpudin Endang 
Published: February 2024

<p><strong><em>Abstract.</em></strong> <em>Some taxpayers do not understand how to operate e-filing because the various features and menus seem complicated. Therefore, assistance in filling out and reporting the Annual SPT is needed to assist individual taxpayers in operating e-filing to submit the Annual SPT. The method applied in this service is assistance in filling out and reporting the annual SPT to WPOP located in the Karawang area with 3 (three) implementation stages, namely the technical guidance stage, the assistance implementation stage, and the evaluation stage. Around 4,102 taxpayers received assistance from the tax volunteer team to submit SPT 1770SS and SPT 1770S. This assistance was carried out offline for 2 (two) months, namely February and March 2023. To measure the success of implementing this assistance, KPP Pratama Karawang and the Tax Center FE Singaperbangsa University Karawang carried out a 2023 tax volunteer service satisfaction survey with 3 (three) indicators assessment, namely assessment of attitudes/behavior with a value scale of 94.46%, assessment of understanding of taxation with a value scale of 94.10%, and assessment of communication skills with a value scale of 94.46%. The survey results show that respondents are very satisfied with the services provided by tax volunteers in helping individual taxpayers to submit annual tax returns.</em></p><p> </p><p><strong>Abstrak.</strong> Sebagian wajib pajak belum memahami cara pengoperasian <em>e-filing </em>karena berbagai fitur dan menu yang terkesan rumit. Oleh karena itu, pendampingan pengisian dan pelaporan SPT Tahunan diperlukan guna membantu wajib pajak orang pribadi dalam mengoperasikan <em>e-filing</em> untuk menyampaikan SPT Tahunan. Metode yang diterapkan dalam pengabdian ini adalah pendampingan pengisian dan pelaporan SPT tahunan kepada WPOP yang terletak di daerah Karawang dengan 3 (tiga) tahap pelaksanaan, yaitu tahap bimbingan teknis, tahap pelaksanaan asistensi, dan tahap evaluasi. Sekitar 4.102 wajib pajak yang mendapat pendampingan dari tim relawan pajak untuk menyampaikan SPT 1770SS dan SPT 1770S. Asistensi ini dilakukan secara luring yang dilaksanakan selama 2 (dua) bulan yaitu Februari dan Maret 2023. Untuk mengukur keberhasilan dari pelaksanaan asistensi ini, KPP Pratama Karawang dan Tax Center FE Universitas Singaperbangsa Karawang melaksanakan survei kepuasan layanan relawan pajak 2023 dengan 3 (tiga) indikator penilaian, yaitu penilaian terhadap sikap/tingkah laku dengan skala nilai 94,46%, penilaian terhadap pemahaman perpajakan dengan skala nilai 94,10%, dan penilaian terhadap kemampuan komunikasi dengan skala nilai 94,46%. Hasil survei tersebut menunjukkan bahwa responden sangat puas dengan pelayanan yang diberikan oleh relawan pajak dalam membantu wajib pajak orang pribadi untuk menyampaikan SPT Tahunan.</p><p> </p><div id="gtx-trans" style="position: absolute; left: -105px; top: 475.889px;"> </div>
Impactos da pandemia da Covid-19 nas Leis de Acesso à Informação no Brasil e no mundo
Authors: Rodrigues Georgete Medleg , Geraldes Elen Cristina , Kaya Gabriela Tyemi 
Published: February 2024

A crise sanitária mundial em função do novo coronavírus, além das graves consequências sociais e econômicas, impactou também na forma de comunicação dos governos com seus cidadãos. No Brasil, houve tentativa do governo federal de alterar a Lei de Acesso Ã Informação. Com base no estudo do Right to Information Rating (RTI), que faz um ranking global das Leis de Acesso Ã Informação no mundo e inclui as mudanças propostas pelos países durante a emergência sanitária, sistematiza-se as alterações propostas, por país, e os tipos de alterações e se foram suspensas as obrigações de direito Ã informação. Faz-se uma breve fundamentação teórica sobre Comunicação Pública, a Lei de acesso Ã informação e pandemias, a contextualização sobre o ranking, como ele funciona. Sintetiza documentos de organismos internacionais que reforçam a obrigatoriedade dos governos em fornecer e dar acesso Ã informação e direito dos cidadãos de ter acesso Ã informação. Conclui que durante a pandemia do novo coronavírus a maioria dos países tentou alterar os prazos de resposta Ã s demandas de informações.
Análise de acesso e divulgação de informação da COVID-19 nos países BRICS
Authors: Matos Christine Martins de , Pinto Adilson Luiz 
Published: February 2024

O objetivo do estudo foi apresentar uma análise de acesso e divulgação de informação da COVID-19 nos países BRICS. Foi feita abordagem de checklist de avaliação de usabilidade nos websites governamentais para atendimento ao Plano Estratégico de Preparação e Resposta definido pela World Health Organization do ano de 2020, contemplando 05 dimensões de questionamentos e procedendo análise no mínimo em 26 websites, com diversos formatos de informação. Conforme resultados emanados, os países BRICS sustentam índices adequados de divulgação de combate Ã COVID-19, tendo facilidade de acesso em grande parte das comunicações de saúde pertinentes Ã gestão de crise existente, e a China apresenta o melhor índice de atendimento ao checklist elaborado. Não houve nenhum país que tenha obtido 100% de atendimento em cada uma das dimensões traçadas o que denota a necessidade de aprimorar e/ou proceder a efetiva divulgação de ações de respostas elaboradas pelo país para que o direito Ã informação seja mais democrático. As conclusões são que a análise por meio de abordagem do checklist elaborado denota o papel preponderante dos serviços de governo eletrônico, possibilitando respostas mais eficazes no combate a emergência da pandemia, com resultados similares ao que consta no Índice de Desenvolvimento de Governo Eletrônico.
Patrimônio científico e memorial de Augusto Ruschi: reflexões, encontros e atualidade do pensamento ecológico no Brasil
Authors: Miguel Marcelo Calderari , Moraes Margarete Farias de , Carvalho Sandra Maria Souza de 
Published: February 2024

O estudo averigua o empenho teórico do naturalista brasileiro Augusto Ruschi (1915-1986) diante a valorização planetária da ecologia para sustentabilidade das nações. Objetiva-se evidenciar os princípios e postulados de Ruschi que sustentam a complexidade dos encontros e parâmetros sobre patrimônio científico e memorial. Dessa forma, é importante demonstrar que o pensamento de Ruschi abre novos espaços de difusão da crítica e de dilemas próprios da linguagem científica. A metodologia envolve uma pesquisa bibliográfica e a análise de conteúdo. Consulta-se trechos da obra e depoimentos do naturalista para enfocar a questão do desenvolvimento, da inclusão social e da educação ambiental. Os resultados indicam um legado social, refletindo a visão progressista no entorno do bens naturais e culturais de valor juridicamente protegido, desde o solo, as águas, a flora, a fauna, as belezas naturais e artificiais, o patrimônio histórico, artístico, turístico, paisagístico, arquivístico, arquitetônico, monumental, espeleológico, arqueológico, fossilífero, geológico, urbanístico e etc. Diversas contribuições servem para se pensar o paradigma social da ciência da informação, fortalecendo e apoiando a abordagem informacional. Conclui-se que Augusto Ruschi foi visionário, edificando um legado, sobretudo, intelectual que avançou internacionalmente. As memórias de Ruschi são fonte inspiradora de políticas públicas, pesquisas e extensões universitárias que desdobram múltiplas potencialidades de exaltar o meio ambiente.