bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occult endometrial cancer in women undergoing hysterectomy for benign indications: a retrospective cohort study in a tertiary hospital in China
Authors: Cao Yang , shi Honghui , Zhuo Xiuping 
Published: January 2024

Abstract

Purpose
To evaluate the feasibility of further reducing the incidence of occult endometrial cancer in women undergoing hysterectomy for benign gynecological indications.
Methods
Patients who underwent hysterectomies for presumed benign gynecologic conditions at Peking Union Medical College Hospital were retrospectively identified. Patients with occult endometrial cancer, which was defined as endometrial cancer diagnosed on postoperative histopathology with no preoperative confirmed malignancy, were selected.
Results
24/7558 (0.32%; 95% CI 0.20–0.47%) patients undergoing hysterectomy for benign indications had occult endometrial cancer. Asymptomatic patients with normal endometrial imaging all tended to have favorable pathology. Heavy menstrual bleeding was the most overlooked AUB pattern in the premenopausal group. In the postmenopausal group, all the patients with serous adenocarcinoma or G3 endometrioid adenocarcinoma histology/stage T1b disease/ LVSI space invasion had a history of persistent or recurrent PMB ≥ 6 months and/or an intracavitary lesion > 20 mm in diameter. 3/4 of the samples of the postmenopausal patients did not have adequate endometrium for evaluation.
Conclusion
To further reduce the incidence of occult endometrial cancer, physicians should focus on the patient's bleeding pattern and actively implement endometrial sampling whenever indicated. Transvaginal ultrasonography is a valuable preoperative evaluation. Hysteroscopy with directed biopsy is the preferred procedure in postmenopausal patients.
Ketone Esters partially and selectively rescue mitochondrial bioenergetics after acute cervical spinal cord injury in rats: A time-course
Authors: Seira Oscar , Park HyoJoon , Liu Jie , Poovathukaran Michelle , Clarke Kieran , Boushel Robert , Tetzlaff Wolfram 
Published: January 2024

Abstract
Spinal cord injury (SCI) pathology and pathophysiology can be attributed to both primary physical injury and secondary injury cascades. Secondary injury cascades involve dysregulated metabolism and energetic deficits, which are directly linked to compromised mitochondrial bioenergetics. Rescuing mitochondrial function and reducing oxidative stress are associated with neuroprotection. In this regard, ketosis after traumatic brain injury (TBI), or after SCI, improves secondary neuropathology by decreasing oxidative stress, increasing antioxidants, reducing inflammation, and improving mitochondrial bioenergetics. Here, we follow up on our previous study and have used an exogenous ketone monoester, (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (KE), as an alternative to a ketogenic diet, focusing on mitochondrial function between 1 and 14 days after injury. Starting 3 hours following a C5 hemi-contusion injury, animals were fed either a standard control diet (SD) or a ketone ester diet (KED) combined with KE administered orally (OKE). We found that mitochondrial function was reduced after SCI at all times post-SCI, accompanied by reduced expression of most of the components of the electron transport chain (ETC). The KE rescued some of the bioenergetic parameters 24 hours after SCI when BHB concentrations were ~ 2 mM, but most of the beneficial effects were observed at 2 weeks after injury with BHB concentrations reaching values of 4–6 mM. To our knowledge, this is the first report of beneficial effects of KE in rescuing mitochondrial function after SCI and demonstrates the suitability of KE to ameliorate the metabolic dysregulation that occurs after traumatic SCI without requiring a restrictive dietary regime.
Genome-wide Mapping of Quantitative Trait Loci Conferring Resistance to Stripe Rust in Spring Wheat Line PI 660072
Authors: Zhou Xinli , Wang Yuqi , Luo Yuqi , Shuai Jie , Jia Guoyun , Chen Hongyang , Zhang Liangqi , Chen Hao , Li Xin , Huang Kebing , Yang Suizhuang , Wang Meinan , Ren Yong , Li Gang , Chen Xianming 
Published: January 2024

Abstract
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most devastating diseases of wheat worldwide. Identifying resistance genes is crucial for developing resistant cultivars to control the disease. Spring wheat PI 660072 (Triticum aestivum) has been identified to possess both adult-plant resistance (APR) and all-stage resistance (ASR) to stripe rust. To elucidate the genetic basis of the resistance in PI 660072, a mapping population consisting of 211 F5 - F7 recombinant inbred lines (RILs) was developed from a cross of PI 660072 with susceptible spring wheat Avocet S. The mapping population was phenotyped for stripe rust responses across five field environments from 2020 to 2022 and genotyped using the 15K SNP (single nucleotide polymorphism) array to map stripe rust resistance loci. The mapping population was also tested at the seedling stage with predominant Chinese Pst races CYR31, CYR32, CYR34 and PST-YX1-3-1 in the greenhouse. Stripe rust resistance genes were identified using the quantitative trait locus (QTL) mapping approach. Two QTL were identified with QYrPI660072.swust-2BL mapped on the long arm of chromosome 2B for ASR and QYrPI660072.swust-4BL on the long arm of chromosome 4B for APR. To facilitate marker-assisted selection breeding, Kompetitive allele specific PCR (KASP) markers, KASP-1269 for QYrPI660072.swust-2BL and KASP-3209 for QYrPI660072.swust-4BL, were developed. These markers could be used to introgress the effective resistance QTL into new wheat cultivars.
LCN2 attenuates sepsis-induced liver injury by alleviating PTGS2-mediated Ferroptosis
Authors: Jiang Yun , Wang Jian-yi , jiang Zhi-tian , Cai Jing-Wen , Song Jie , Wang Jing , Zhou Zhen , Wang Qian , Zhao Gang , Nie Hong-Ming , Ling Qi-Hua 
Published: January 2024

Abstract
Sepsis, which is strongly linked to sepsis-induced liver injury, is a significant contributor to mortality in critical care units. In this study, we explore the role of lipocalin 2 (LCN2) in sepsis-induced liver injury. We observed increased expression of LCN2 in the livers of septic mice induced by caecal ligation and puncture (CLP), as well as in hepatocytes treated with lipopolysaccharide (LPS). To elucidate the function of LCN2 in sepsis-induced liver injury, we established septic mice with LCN2 knockdown. To evaluate liver injury in mice, levels of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) were measured in both serum and liver samples. Oxidative stress was evaluated by measuring the levels of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in serum and liver samples. Additionally, ferroptosis was assessed by examining the expression of Prostaglandin-Endoperoxide Synthase 2 (Ptgs2), solute carrier family 7 member 11 (Slc7a11) and glutathione peroxidase 4 (Gpx4) in the liver tissue of the mice. Our findings demonstrated that LCN2 knockdown significantly exacerbated sepsis-induced liver injury, oxidative stress, and ferroptosis. Moreover, in an in vitro study, LCN2 overexpression notably ameliorated LPS-induced liver injury, oxidative stress, and ferroptosis in hepatocytes by inhibiting PTGS2 expression. In conclusion, our study provides evidence that LCN2 attenuates sepsis-induced liver injury by alleviating PTGS2-mediated ferroptosis.
High-Order Χ Points Driven Multi-Polarized Emission in a Square Plasmonic Lattice
Authors: Wang Wenxin , Hu Jiang , Zhang Yiqun , Nečada Marek , Yuan Jiazhi , Xiao Jiamin , Zhao Xuchao 
Published: January 2024

Abstract

Multi-polarized light sources are important in applications such as polarization multiplexing signals and polarization imaging. In photonic and plasmonic systems, one way to achieve multi-polarized light sources is via high-symmetry points of the lattices. In this work, we designed a centimeter-scale square lattice of aluminum nanocones array mimics an infinite lattice to facilitate exploration the possibility of multi-polarized beams emission at high-symmetry points. Compared to beam directly diffract on the lattices, after coupling plasmonic lattice with dye gain, four beams of multi-polarized with a symmetric distribution generated at Χ (1) points within an iso-frequency plane. Detailed analysis of far-field emission polarizations and near-field dipole distributions linked to Χ (1) points emissions confirms their origin as the singlet eigenmode B2 at Χ (2) points. This work experimental generated multi-polarized light sources via high-symmetry points of the lattice and identified the mode of amplified spontaneous emissions by using symmetry arguments, which provides new application prospects in polarized imaging and optical communication.
Risk prediction model of acute kidney injury in geriatric pelvic fracture patients
Authors: Wang Lei , Ruan Feng , Ge Yun , Ge Huamin , Wang Ziyi , Xu Shanxiang 
Published: January 2024

Abstract
There is a paucity of information pertaining to the epidemiology and risk factors associated with acute kidney injury (AKI) in geriatric patients diagnosed with pelvic fractures. A retrospective analysis was conducted, employing multivariate analysis and model prediction analysis to identify these factors. A total of 247 pelvic fracture patients were admitted to our trauma centre between January 2021 and December 2021, and of these patients, 78 (31.6%) had AKI. During the study period, a total of 247 pelvic fracture patients were 65 years or older. Among them, 78(31.6%) developed AKI, and 14.3% of patients with AKI underwent Renal replacement therapy (RRT). Multivariate logistic regression showed that hemoglobin (Hb) (OR=0.852, p＜0.001), Albumin(OR = 0.683, p＜0.001), Injury Severity Score (ISS) (OR = 1.442, p＜0.001), Lactate(OR = 24.079, p＜0.001) , Base excess (BE)(OR=0.509, p＜0.001),CK(OR=18.713, p＜0.001), Tile C fractures (OR =10.244, p＜0.001) ,Chest injury(OR=20.272, p＜0.001) were risk factors of AKI in geriatric pelvic fracture patients. Early identification and effective intervention can improve the prognosis of geriatric patients with pelvic fracture.
A Qualitative Study on Iranian EFL Teachers’ Perceptions of a Diversified Education
Authors: zadeh Seyed Mohammad Reza Marvasti , Varnosfadrani Azizollah Dabaghi , Amiryousefi Mohammad 
Published: January 2024

Abstract

One characteristic of societal changes is the emergence of societies that possess a diverse and pluralistic orientation towards digital platforms. These societies recognize the importance of implementing pluralistic educational approaches within their educational programs. The objective of this research was to investigate the perspectives of Iranian English as a Foreign Language teachers regarding a diverse digital education. To achieve this goal, a qualitative thematic analysis and a semi-structured interview were employed. The study participants consisted of 20 Iranian English teachers, both male and female, who were selected through convenience sampling. The results of the analysis revealed several key themes, including the utilization of diverse teaching methods, materials, tools, and activities; the development of curricula that cater to the interests, needs, and opinions of students; the provision of equal opportunities for all students to maximize their potential; the promotion of individual and group pride and identity; the encouragement of critical thinking skills in students; the establishment of a fair distribution of power within society; the recognition and utilization of individual and group differences; the emphasis on personal growth and development; the creation of inclusive classrooms that value all perspectives, experiences, and thought processes; the teaching of effective responses to cultural and ethnic differences; the incorporation of diversity in evaluation procedures; the importance of fairness in the evaluation process; the evaluation of learning outcomes and achievements; the promotion of multicultural awareness among students; and the encouragement of gender equality. These findings hold important implications for EFL learners, teachers, and curriculum planners.
Exploring Essential Newborn Care Practices and Predictors Among Non-Institutional Births in Urban Bangladesh
Authors: Khanam Shimlin Jahan , Alam Md Badsha , Kabir Md Awal , Khan Md Nuruzzaman 
Published: January 2024

Abstract

Background Non-institutional births, often occurring at home or in traditional settings, remain prevalent in Bangladesh despite ongoing efforts to promote facility-based deliveries. Ensuring essential newborn care (ENC) practices for these non-institutional births is crucial for reducing neonatal mortality and improving child health outcomes. This study aimed to identify current status and factors associated with the adoption of ENC practices among non-institutional births in urban areas of Bangladesh. Methods A secondary analysis of the 2165 mother-child dyads was conducted extracted from the 2019 Bangladesh Urban Health Facility Survey. Six ENC indicators as well as their composite index was considered as the outcome variables. Respondents’ socio-demographic factors were considered as the explanatory variables. Multivariate logistic regression model was used to explore association between outcome and explanatory variables. Results Approximately 37% of all mothers reported employing a minimum of three out of the six ENC practices. Among individual indicators, the highest adherence was observed for the use of a sterilized instrument to sever the umbilical cord (90%), while the lowest adherence was noted for delayed bathing (7.4%). The likelihood of adopting at least three of the six ENC indicators was lower among mothers in relatively higher wealth quintiles, while it was higher among those residing in non-slum areas of city corporations and in the divisions of Chattogram, Khulna, and Sylhet. Concerning individual indicators, factors associated with each ENC practice varied, with no specific indicator consistently significant across all categories. Conclusion More than two-thirds of all mothers do not report employing a minimum of three ENC practices in urban areas of Bangladesh. This lower adherence to ENC practices may be linked to elevated neonatal and under-five mortality rates in Bangladesh. There is a crucial need for awareness-building programs to educate the population about the significance of practicing ENC for improving child health outcomes.
Renal Amyloidogenic Leukocyte Chemotactic Factor 2 Combined with Immunoglobulin A Nephropathy: 2 Case Reports and literature review
Authors: Zhao Li , Li Yanan , Shen Ruihua , Niu Dan , Han Wei xia , Wang Chen , Yao Shulei , Zhang Xiao hua , Zhang Lingyun , Wang Lihua , Qiao Xi 
Published: January 2024

Abstract

Amyloidogenic leukocyte chemotactic factor 2 (ALECT2) is a recently discovered pathological type of amyloidosis that primarily affects the kidney. Though immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease in China, the coexistence of IgAN and ALECT2-associated renal amyloidosis has rarely been reported. Herein, we present 2 patients with renal ALECT2 amyloidosis and mesangial IgA deposition. After traditional proteinuria reduction therapy, their serum creatinine increased slightly along with stable proteinuria. In conclusion, the management of renal ALECT2 amyloidosis in conjunction with IgAN is mostly centered on managing IgAN.
Targeting host-virus interactions: In silico analysis of the binding of human milk oligosaccharides to viral proteins involved in respiratory infections
Authors: Ali Anees Ahmed Mahaboob , Vishal Adarsh , Nelson Everette Jacob Remington 
Published: January 2024

Abstract
Respiratory viral infections, a major public health concern, necessitate the continuous development of novel antiviral strategies, particularly in the face of emerging and re-emerging pathogens. In this study, we explored the potential of human milk oligosaccharides (HMOs) as broad-spectrum antiviral agents against key respiratory viruses. By examining the structural mimicry of host cell receptors and their known biological functions, including antiviral activities, we assessed the ability of HMOs to bind and potentially inhibit viral proteins crucial for host cell entry. Our in silico analysis focused on viral proteins integral to host-virus interactions, namely, the hemagglutinin protein of influenza, fusion proteins of respiratory syncytial and human metapneumovirus, and the spike protein of SARS-CoV-2. Using molecular docking and simulation studies, we demonstrated that HMOs exhibit varying binding affinities to these viral proteins, suggesting their potential as viral entry inhibitors. This study identified several HMOs with promising binding profiles, highlighting their potential in antiviral drug development. This research provides a foundation for utilizing HMOs as a natural source for designing new therapeutics, offering a novel approach in the fight against respiratory viral infections.
Risk factors and prognostic significance of early postoperative complications for patients who underwent pneumonectomy for lung cancer
Authors: Batıhan Güntuğ , Ceylan Kenan Can , Kaya Şeyda Örs 
Published: January 2024

Abstract

Background
Although pneumonectomy has relatively high mortality and morbidity rates, it remains valid in the surgical treatment of lung cancer. This study aims to evaluate the prognostic significance of postoperative complications after pneumonectomy and demonstrate the risk factors related to early postoperative complications.
Methods
Patients who underwent pneumonectomy for non-small cell lung cancer between January 2008 and May 2021 were included in the study. Factors related to the development of early postoperative complications and overall survival were evaluated by univariate and multivariate analyses.
Results
A total of 136 patients were included in the study. Early postoperative complications were seen in 33 (24.3%) patients and late postoperative complications in 7 (5.1%) patients. The amount of cigarette smoking, and the operation side were the independent variables that affect the development of early postoperative complications. In multivariate analysis, smoking amount and pericardial invasion were associated with the development of postoperative hemorrhage, and advanced age was associated with the development of postoperative pneumonia.
Conclusions
Early postoperative complications have a negative effect on the prognosis after pneumonectomy therefore careful patient selection and preoperative risk assessment are essential to minimize the occurrence of complications and improve patient outcomes.
Trial registration
This observational study was approved by the (Ethical Committee of Dr. Suat Seren Chest Diseases and Chest Surgery Education and Research Center) Institutional Review Board of our center (E-49109414-604.02.02-218625439).
Exploring cognitive reserve's influence: unveiling the dynamics of digital telerehabilitation in Parkinson's Disease Resilience
Authors: Isernia Sara , Tella Sonia Di , Rossetto Federica , Borgnis Francesca , Realdon Olivia , Cabinio Monia , Pagliari Chiara , Torchio Alessandro , Castagna Anna , Blasi Valeria , Silveri Maria Caterina , Baglio Francesca 
Published: January 2024

Abstract

Telerehabilitation represents a novel digital approach to deliver rehabilitation for Parkinson's Disease (PD), particularly beneficial in the early stages of the condition to foster resilience, the capacity of the brain to maintain function with aging and disease. Within the resilience framework, the present work aims to investigate the role of cognitive reserve (CR) on response after telerehabilitation by deepening how experiential factors mediate the link between neural reserve and rehabilitation-enhanced functional capabilities changes. Forty-two PD participants (23 males, mean age: 68.88 ± 8.02) were administered a 4-month multidimensional neuromotor telerehabilitation intervention. To test the role of the CR on the link between brain change and treatment response the following measures were assessed: 1) CR proxy through the Cognitive Reserve Index questionnaire (CRIq), 2) disease-related brain changes by the total gray volume (TGV) index extracted by a 3T MRI examination (T1-3D sequence), 3) treatment response by computing 6-Minute Walk Distance (6MWD) Δ changes (baseline-after treatment). Participants were categorized as responders (N = 23) or non-responders (N = 19) based on 6MWD Minimal Clinical Important Difference. Correlations between neuromotor functions, CR proxy, and TGV were tested both at baseline and after treatment separately for responders and non-responders. Then, a multiple regression model (Wald backward option) was run to test significant predictors of 6MWT changes in each group. Results showed a direct association between 6MWD and CRIq both at baseline (r = 0.582, p < 0.001) and after the treatment (r = 0.681, p < 0.001) only in the responders. Moreover, in this group, the CRIq score (β = 0.24, p = 0.024), and especially the CRIq Leisure-Time sub-index (β = 0.19, p = 0.067), significantly predicted a 6MWD increment, together with the 6MWD baseline score (β = 0.70, p < 0.001). These findings suggest the role of the CR as a predictor and booster of telerehabilitation effect on PD neuromotor functioning.
Bi-Objective Optimization of Bandwidth Resources and Energy Consumption for Efficient Virtual Machine Placement in Cloud Computing
Authors: Deresa Ketema , Lemma Frezewd 
Published: January 2024

Abstract
Cloud computing transformed IT organizations with its on-demand model, notably Infrastructure as a Service (IaaS). Cloud providers manage extensive physical devices, consuming substantial energy and bandwidth for data traffic during virtual machine deployment. Balancing energy and bandwidth are critical. This thesis presents BOHGOA integrated with ACO to optimize virtual machine placement in clouds, simultaneously considering bandwidth and energy. It yields Pareto-optimal solutions for this trade-off. Using CloudSim, BOHGOA outperformed GA, ACO, and FFD algorithms, reducing bandwidth consumption by 54.14%, 32.11%, 57.47% (240 VMs) and 38.12%, 22.76%, 47.05% (500 VMs) respectively. Additionally, it decreased physical machine energy usage by 37.70%, 34.01%, 40.14% (240 VMs) and 27.50%, 22.28%, 30.52% (500 VMs) respectively. These results underscore BOHGOA's effectiveness in optimizing cloud VM placement.
Iron sucrose induced ferroptosis for recruiting and awakening immune cells in the ascite fluid of hepatocellular carcinoma: Preparation for immunotherapy
Authors: Yu Baofa , Jing Guoqin , Zhang Hongxi , Jing Peng , Gao Feng 
Published: January 2024

Abstract
Background: Cervical cancer is one of the most common and deadly cancers in women, for who with persistent infection of high-risk human papillomavirus (HPV). Current treatment of cervical cancer involves radical hysterectomy, radiotherapy and chemotherapy or a combination.
Objective: We investigated if hapten enhanced intratumoral chemotherapy (HEIC) was effective in boosting immunity for effective treatment of precancerous cervical lesions and HPV infection
Study Design: We used single-cell RNA sequencing (scRNA-Seq) to obtain transcriptome profiles of 40239 cells from biopsy of precancerous cervical lesions at the cervix directly from one patient before the start of HEIC and about 1 week after HEIC. The blood samples were taken at same time as biopsies. We compared the expression characteristics of malignant epithelial cells and immune cells, including Epithelial Cells, Ecs, Fibroblasts, Mural Cells, Tcells, Bcells, TandNK Neutrophils, Mast Cells, MPs, and Platelets, as well as the dynamic changes in cell percentage and cell subtype heterogeneity.
Results: Intratumoral injection of chemotherapy drug plus hapten induces acute immune response in precancerous cervical lesions with HPV, and further awakens immune cells to prevent abnormal proliferation of the precancerous cells.
Conclusion: HEIC provides a potential treatment methodfor cervical cancer and HPV infection tailored to each patient's condition.