bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut microbiota in adults with moyamoya disease: characteristics and biomarker identification
Authors: Yu Xiaofan , Ge Peicong , Zhai Yuanren , Liu Wei , Zhang Qian , Ye Xun , Liu Xingju , Wang Rong , Zhang Yan , Zhao Jizong , Zhang Dong 
Published: October 2023

Background and purposeWhen it comes to the onset of moyamoya disease (MMD), environmental variables are crucial. Furthermore, there is confusion about the relationship between the gut microbiome, an environmental variable, and MMD. Consequently, to identify the particular bacteria that cause MMD, we examined the gut microbiome of MMD individuals and healthy controls (HC).MethodsA prospective case-control investigation was performed from June 2021 to May 2022. The fecal samples of patients with MMD and HC were obtained. Typically, 16S rRNA sequencing was employed to examine their gut microbiota. The QIIME and R softwares were used to examine the data. The linear discriminant analysis effect size analysis was used to determine biomarkers. Multivariate analysis by linear models (MaAsLin)2 were used to find associations between microbiome data and clinical variables. Model performance was assessed using the receiver operating characteristic curve and the decision curve analysis.ResultsThis investigation involved a total of 60 MMD patients and 60 HC. The MMD group’s Shannon and Chao 1 indices were substantially lower than those of the HC cohort. β-diversity was significantly different in the weighted UniFrac distances. At the phylum level, the relative abundance of Fusobacteriota/Actinobacteria was significantly higher/lower in the MMD group than that in the HC group. By MaAsLin2 analysis, the relative abundance of the 2 genera, Lachnoclostridium and Fusobacterium, increased in the MMD group, while the relative abundance of the 2 genera, Bifidobacterium and Enterobacter decreased in the MMD group. A predictive model was constructed by using these 4 genera. The area under the receiver operating characteristic curve was 0.921. The decision curve analysis indicated that the model had usefulness in clinical practice.ConclusionsThe gut microbiota was altered in individuals with MMD, and was characterized by increased abundance of Lachnoclostridium and Fusobacterium and decreased abundance of Bifidobacterium and Enterobacter. These 4 genera could be used as biomarkers and predictors in clinical practice.
Unraveling the role of disulfidptosis-related LncRNAs in colon cancer: a prognostic indicator for immunotherapy response, chemotherapy sensitivity, and insights into cell death mechanisms
Authors: Chi Hao , Huang Jinbang , Yan Yang , Jiang Chenglu , Zhang Shengke , Chen Haiqing , Jiang Lai , Zhang Jieying , Zhang Qinghong , Yang Guanhu , Tian Gang 
Published: October 2023

Background: Colon cancer, a prevalent and deadly malignancy worldwide, ranks as the third leading cause of cancer-related mortality. Disulfidptosis stress triggers a unique form of programmed cell death known as disulfidoptosis, characterized by excessive intracellular cystine accumulation. This study aimed to establish reliable bioindicators based on long non-coding RNAs (LncRNAs) associated with disulfidptosis-induced cell death, providing novel insights into immunotherapeutic response and prognostic assessment in patients with colon adenocarcinoma (COAD).Methods: Univariate Cox proportional hazard analysis and Lasso regression analysis were performed to identify differentially expressed genes strongly associated with prognosis. Subsequently, a multifactorial model for prognostic risk assessment was developed using multiple Cox proportional hazard regression. Furthermore, we conducted comprehensive evaluations of the characteristics of disulfidptosis response-related LncRNAs, considering clinicopathological features, tumor microenvironment, and chemotherapy sensitivity. The expression levels of prognosis-related genes in COAD patients were validated using quantitative real-time fluorescence PCR (qRT-PCR). Additionally, the role of ZEB1-SA1 in colon cancer was investigated through CCK8 assays, wound healing experiment and transwell experiments.Results: disulfidptosis response-related LncRNAs were identified as robust predictors of COAD prognosis. Multifactorial analysis revealed that the risk score derived from these LncRNAs served as an independent prognostic factor for COAD. Patients in the low-risk group exhibited superior overall survival (OS) compared to those in the high-risk group. Accordingly, our developed Nomogram prediction model, integrating clinical characteristics and risk scores, demonstrated excellent prognostic efficacy. In vitro experiments demonstrated that ZEB1-SA1 promoted the proliferation and migration of COAD cells.Conclusion: Leveraging medical big data and artificial intelligence, we constructed a prediction model for disulfidptosis response-related LncRNAs based on the TCGA-COAD cohort, enabling accurate prognostic prediction in colon cancer patients. The implementation of this model in clinical practice can facilitate precise classification of COAD patients, identification of specific subgroups more likely to respond favorably to immunotherapy and chemotherapy, and inform the development of personalized treatment strategies for COAD patients based on scientific evidence.
Imaging-based adipose biomarkers for predicting clinical outcomes of cancer patients treated with immune checkpoint inhibitors: a systematic review
Authors: Pei Xinyu , Xie Ye , Liu Yixuan , Cai Xinyang , Hong Lexuan , Yang Xiaofeng , Zhang Luyao , Zhang Manhuai , Zheng Xinyi , Ning Kang , Fang Mengyuan , Tang Huancheng 
Published: October 2023

BackgroundSince the application of Immune checkpoint inhibitors (ICI), the clinical outcome for metastatic cancer has been greatly improved. Nevertheless, treatment response varies in patients, making it urgent to identify patients who will receive clinical benefits after ICI therapy. Adipose body composition has proved to be associated with tumor response. In this systematic review, we aimed to summarize the current evidence on imaging adipose biomarkers that predict clinical outcomes in patients treated with ICI in various cancer types.MethodsEmbase and PubMed were searched from database inception to 1st February 2023. Articles included investigated the association between imaging-based adipose biomarkers and the clinical outcomes of patients treated with ICI. The methodological quality of included studies was evaluated through Newcastle- Ottawa Quality Assessment Scale and Radiomics Quality Score tools. ResultsTotally, 22 studies including 2256 patients were selected. Non-small cell lung cancer (NSCLC) had the most articles (6 studies), followed by melanoma (5 studies), renal cell carcinoma (RCC) (3 studies), urothelial carcinoma (UC) (2 studies), head and neck squamous cell carcinoma (HNSCC) (1 study), gastric cancer (1 study) and liver cancer (1 study). The remaining 3 studies investigated metastatic solid tumors including various types of cancers. Adipose biomarkers can be summarized into 5 categories, including total fat, visceral fat, subcutaneous fat, intramuscular fat and others, which exerted diverse correlations with patients’ prognosis after being treated with ICI in different cancers. Most biomarkers of body fat were positively associated with survival benefits. Nevertheless, more total fat was predictable of worse outcomes in NSCLC, while inter-muscular fat was associated with poor clinical benefits in UC. ConclusionThere is relatively well-supported evidence for imaging-based adipose biomarkers to predict the clinical outcome of ICI. In general, most of the studies show that adipose tissue is positively correlated with clinical outcomes. This review summarizes the significant biomarkers proven by researches for each cancer type. Further validation and large independent prospective cohorts are needed in the future. The protocol of this systematic review has been registered at the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO, registration no: CRD42023401986).
A clinical-radiomics nomogram based on multimodal ultrasound for predicting the malignancy risk in solid hypoechoic breast lesions
Authors: Shiyan Guo , Liqing Jiang , Yueqiong Yan , Yan Zhang 
Published: October 2023

BackgroundIn routine clinical examinations, solid hypoechoic breast lesions are frequently encountered, but accurately distinguishing them poses a challenge. This study proposed a clinical-radiomics nomogram based on multimodal ultrasound that enhances the diagnostic accuracy for solid hypoechoic breast lesions.MethodThis retrospective study analyzed ultrasound strain elastography (SE) and automated breast volume scanner images (ABVS) of 423 solid hypoechoic breast lesions from 423 female patients in our hospital between August 2019 and May 2022. They were assigned to the training (n=296) and validation (n=127) groups in a 7:3 ratio by generating random numbers. Radiomics features were extracted and screened from ABVS and SE images, followed by the calculation of the radiomics score (Radscore) based on these features. Subsequently, a nomogram was constructed through multivariate logistic regression to assess the malignancy risk in breast lesions by combining Radscore with Breast Imaging Reporting and Data System (BI-RADS) scores and clinical risk factors associated with breast malignant lesions. The diagnostic performance, calibration performance, and clinical usefulness of the nomogram were assessed by the area under the curve (AUC) of the receiver operating characteristic curve, the calibration curve, and the decision analysis curve, respectively.ResultsThe diagnostic performance of the nomogram is significantly superior to that of both the clinical diagnostic model (BI-RADS model) and the multimodal radiomics model (SE+ABVS radiomics model) in training (AUC: 0.972 vs 0.930 vs 0.941) and validation group (AUC:0.964 vs 0.916 vs 0.933). In addition, the nomogram also exhibited a favorable goodness-of-fit and could lead to greater net benefits for patients.ConclusionThe nomogram enables a more effective assessment of the malignancy risk of solid hypoechoic breast lesions; therefore, it can serve as a new and efficient diagnostic tool for clinical diagnosis.
The effect of compression and combined compression-tactile stimulation on lower limb somatosensory acuity
Authors: Marchant Ashleigh , Wallwork Sarah B. , Ball Nick , Witchalls Jeremy , Waddington Gordon 
Published: October 2023

BackgroundLower limb somatosensation and proprioception are important for maintaining balance. Research has shown that compression garments or exposure to textured surfaces, can enhance somatosensation however, little is known about the effect of combined compression and texture on somatosensory acuity in the lower limb. This study aimed to assess the effects of combined compression socks with a plantar textured sole, on lower limb somatosensory acuity.MethodsThirty participants completed a somatosensory acuity task (active movement extent discrimination apparatus; AMEDA) under three conditions: barefoot (control condition), standard knee-high compression sock (compression sock), and knee-high compression sock with internal rubber nodules situated on the sole (textured-compression sock). Somatosensory acuity was assessed between the different sock conditions for the (i) entire group, (ii) high performers, and (iii) low performers. It was hypothesized that low performers would see gains wearing either sock, but the greatest improvement would be in the textured-compression sock condition.ResultsAMEDA scores were not significantly different between conditions when the entire group was analyzed (p = 0.078). The low performers showed an improvement in somatosensory acuity when wearing the compression sock (p = 0.037) and the textured compression sock (p = 0.024), when compared to barefoot, but there was no difference between the two sock conditions (p &gt; 0.05). The high performers did not show any improvement (p &gt; 0.05 for all).ConclusionThese findings demonstrate that additional sensory feedback may be beneficial to individuals with lower baseline somatosensory acuity but is unlikely to provide benefit for those with higher somatosensory acuity.
The Association of Different Genetic Variants with the Development of Hypoxic–Ischemic Encephalopathy
Authors: Pavlov Vesna , Papazovska Cherepnalkovski Anet , Marcic Marino , Marcic Ljiljana , Kuzmanic Samija Radenka 
Published: October 2023

The aim of this study is to investigate the frequency of six tag SNPs (single nucleotide polymorphisms) within specific genes (F2, F5, F7, MTHFR, NOS2A, PAI 2-1, PAI 2-2, and PAI 3-3): F2 (rs1799963), F5 (rs6025), F7 (rs6046), NOS 2 (rs1137933), PAI 2 (SERPINB2) (rs6103), MTHFR (rs1801133). The study also investigates their association with the development and severity of HIE. The genes F2, F5, and F7 code for proteins involved in blood clotting. MTHFR is a gene that plays a significant role in processing amino acids, the fundamental building blocks of proteins. NOS2A, PAI 2-1, PAI 2-2, and PAI 3-3 are genes involved in the regulation of various physiological processes, such as the relaxation of smooth muscle, regulation of central blood pressure, vasodilatation, and synaptic plasticity. Changes in these genes may be associated with brain injury. This retrospective study included 279 participants, of which 132 participants had Hypoxic–Ischemic Encephalopathy (HIE) and 147 subjects were in the control group. Our study found that certain genetic variants in the rs61103 and rs1137933 polymorphisms were associated with hypoxic–ischemic encephalopathy (HIE) and the findings of the magnetic resonance imaging. There was a correlation between Apgar scores and the degree of damage according to the ultrasound findings. These results highlight the complex relationship between genetic factors, clinical parameters, and the severity of HIE.
Evaluation of Toxoplasma gondii, CMV, and Rubella Seropositivity and Avidity Tests in the First Trimester of Pregnancy: Why to Test?
Authors: UĞUR Ayşe Rüveyda , ESENKAYA Ümmügülsüm , GÜNENC Oğuzhan 
Published: October 2023

Objective: The influence of intrauterine and perinatal infections on fetal and neonatal mortality rates and childhood morbidity is substantial. Toxoplasmosis gondii, cytomegalovirus (CMV), and rubella are widely recognized as the major causative agents of in utero infection. The surveillance of preventable and treatable diseases within populations at risk are crucial for public health. The objective of this study is to investigate the seropositivity rates and avidity incidences of T. gondii, CMV, and rubella in pregnant women during the first trimester.
Methods: The electrochemiluminescence immunoassay method (Elecsys, Roche, Germany) was employed for the detection of the anti-Toxo IgM, anti-Toxo IgG, anti-CMV IgM, anti-CMV IgG, anti-rubella IgM, and anti-rubella IgG during the time period of January 1, 2021, to June 15, 2023. The anti-Toxo IgG, anti-CMV, and anti-rubella IgG avidity tests were performed with the enzyme-linked fluorescent assay method (VIDAS, bioMérieux, France).
Results: The T. gondii IgM incidance was 2.1%; and the T. gondii IgG seroprevalance was 22%. For T. gondii, low avidity was observed in 13.6% (n = 31) of cases, while high avidity index was detected in 75.8% (n = 172) of cases. The anti-CMV IgM incidance was 1.6%; while IgG seroprevalance was 96.9%. The IgG avidity with a high index for CMV was determined as 99.4%. The anti-rubella IgM incidance was 0.8%; while the IgG seroprevalance was found to be 98.7%. The IgG avidity with a high index for Rubella was 99.1%.
Conclusion: Seroprevalance of T.gondii, CMV, and rubella may vary according to geographical and socioeconomic conditions. Treatment for T. gondii diagnosed during pregnancy, preventive behavioral measures for CMV and vaccination against rubella prior to pregnancy may help reduce congenital infections. The prioritization of T. gondii, CMV, and rubella screening in high-risk populations, including women of reproductive age and pregnant women, is crucial for public health.
PERSPEKTIF EKONOMI ISLAM TERHADAP PENETAPAN NISBAH BAGI HASIL TABUNGAN UMUM SYARIAH DI BMT UGT NUSANTARA CAPEM NUSA DUA KEDONGANAN BADUNG BALI
Authors: Hasan Zainol , Syarifuddin Syarifuddin , Lutfiyah Sri 
Published: October 2023

Since the time of Rasulullah SAW, the economy of Muslims has been carried out with contracts that are in accordance with sharia and have become a tradition. Islamic economics is a social science that studies the economic problems of society based on Islamic values. The instrument used to apply sharia principles in the financial sector is the Baitul Maal wat Tamwil (BMT). One of them is BMT UGT Nusantara Sub Branch Nusa Dua. In sharia savings at BMT UGT Nusantara Sub Branch Nusa Dua, the percentages are set from BMT, but the process for taking profit sharing ratios is not explained, so it is not known whether the profit sharing has been fair or not. Based on this phenomenon, the focus of research is how to determine the profit sharing ratio for sharia savings at BMT UGT Nusantara Sub Branch Nusa Dua? and what is the review from the perspective of Islamic economics?. In this study, researchers used a type of qualitative research. Data collection are observation, interview and documentation. There are three procedures in data analysis techniques, they are: data reduction, data presentation and data verification. Determination of profit-sharing ratios for sharia savings using a akad musyarakah with a profit sharing of 70% for BMT and 30% for members. The nominal amount of profit-sharing rupiah for each member will differ depending on the length and amount of money kept at the BMT. The Islamic economic perspective on determining profit sharing ratios through musyarakah contracts in BMT is in accordance with Islamic economic principles because it has been fair.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUASAN KONSUMEN
Authors: Hidayan Nanda , Faiz Zainuddin  , Nurul Nafilah  
Published: October 2023

Beberapa faktor yang mempengaruhi kepuasan konsumen adalah harga dan lokasi. Harga merupakan nilai tukar dari sebuah produk atau jasa yang nilainya ditentukan dan ditetapkan oleh penjual atau pembeli melalui tawar menawar. Lokasi adalah tempat bertransaksi berbagai aktivitas pemasaran yang berusaha memperlancar dan mempermudah penyampaian atau penyaluran barang dan jasa dari produsen kepada konsumen.
Metode penelitian yang dilakukan adalah metode kuantitatif melalui pendekatan asosiatif. Lokasi penelitian, yakni Toko Berkah Ilahi Mayang Jember. Sampel yang digunakan dalam penelitian ini yakni berjumlah 80 orang. Metode pemilihan sampel dalam penelitian ini berupa sampel jenuh (sensus). Teknik analisis data menggunakan uji validitas, uji reliabilitas, uji asumsi klasik, uji regresi linier berganda, uji-t, dan uji-f.
Hasil penelitian ini menunjukkan bahwa: (1) Harga (X1) berpengaruh signifikan secara parsial terhadap kepuasan konsumen di toko berkah Ilahi Mayang Jember; (2) Lokasi (X2) berpengaruh signifikan secara parsial terhadap kepuasan konsumen di toko Berkah Ilahi Mayang Jember; dan (3) Harga (X1) dan Lokasi (X2) berpengaruh signifikan secara simultan terhadap kepuasan konsumen di toko Berkah Ilahi Mayang Jember. Berdasarkan analisis tersebut, maka diketahui bahwa arah dan besarnya tingkat hubungan antara variabel harga dan lokasi terhadap kepuasan konsumen sebesar 62,7%.
STRATEGI MANAJEMEN PEMASARAN ISLAMI DALAM PENINGKATAN PENJUALAN PADA KEDAI SATE H.QADIR
Authors: Amir Amir , Al A'luf Wilda 
Published: October 2023

Marketing management strategy is a process capable of delivering organizations/companies to large market opportunities to increase sales and achieve the expected advantages. The marketing management strategy is also an important tool so that companies are able to win the competition. The purpose of marketing is to carry out transactions, serve, fulfill needs, and desires to satisfy consumers. While the marketing function is product development, if the products that have been circulating experience a decrease, to avoid this, it is necessary to add product functions according to business development.

From the description of the problems that occur, the author focuses on two problem formulations, namely:
1) How is the marketing management strategy in increasing sales at Kedai Sate H.Qadir Denpasar Bali 2) What are the supporting and inhibiting factors of the marketing management strategy in increasing sales at Kedai Sate H.Qadir Denpasar Bali.
The research method used is a qualitative research method with data collection techniques by means of observation, interviews, and documentation. The results obtained from this researcher are expected to provide a detailed and systematic explanation of Islamic marketing management strategies in increasing sales.
The Islamic marketing management strategy carried out at Kedai Sate H. Qadir uses (marketing mix) called the 4Ps of product, price, promotion, place. The priority supporting factor is having a strategic place that is easily accessible to consumers and also communication aimed at attracting consumers who are outside the Denpasar Bali area. The inhibiting factor at Kedai Sate H. Qadir is that there are quite a lot of conditions in the Denpasar Bali area.
IMPLEMENTASI MANAJEMEN RESIKO DI ERA NEW NORMAL
Authors: Baiq Paria Indrawati  , Ahmadi  , Nanda Hidayan Sono  
Published: October 2023

Implementasi Manajemen resiko di era new normal dilakukan dalam sebuah perusahaan dengan tujuan utama suatu perusahaan atau lembaga dapat tetap eksis, berinovasi dan memberikan manfaat di tengah keadaan yang tidak memungkinkan. Implementasi manajemen resiko sangat penting dilakukan karena semua perusahan berpotensi mengalami resiko kapan dan dimana saja, oleh karenanya sebagai preventif manajemen resiko.
Motode penilitian yang digunakan adalah penelitian kualitatif, dengan menggunakan pendekatan studi kasus. Subyek dari penelitian adalah bagaimana implentasi manajemen resiko yang digunakan Home Industri Datu Lunge sehingga mampu bertahan dan tetap eksis meski di era pandemi bahkan era new normal. Pengumpulan data dilakukan dengan tiga cara yaitu observasi, wawancara dan dokumentasi. Sedangkan analisis data dilakukan dengan beberapa tahap yaitu reduksi data, penyajian data dan penarikan kesimpulan.
Hasil dari penelitian ini menunjukkan bahwa Home Industri Datu Lunge menggabungkan sumber eksternal dan internal dalam pengimplementasian manajemen resiko. Proses Implementasi manajemen resiko yang dilakukan Home Industri Datu Lunge ialah dimulai dari identifikasi resiko yang dikemas dengan adanya RAB, memperkirakan terjadinya resiko dengan istilah LOSICOT, mencari alternatif resiko, implementasi keputusan, monitoring dan evaluasi dan untuk mengetahui sejauh mana perkembangan dan penurunan perusahaan Home Industri Datu Lunge menerapkan studi analisis SWOT. Faktor pendukung dalam implementasi manajemen resiko di era new normal ialah dengan adanya dukungan dari masyarakat sekitar, kekompakan antar lini organisasi, ruang kerja yang tidak membutuhkan jangkauan dunia luar, harga yang mudah dijangkau dan kesadaran akan manfaat produk Datu Lunge pada saat yang tepat, Adapun faktor penghambatnya adalah: produksi yang dihasilkan tidak sebanding dengan pemesanan, SDM yang minim sebab domisili lintas kabupaten, kurang mengekplorasikan diri, target inovatif kurang maksimal dan pendistribusian kurang merata.