bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress report of a cross‐organ and biomarker‐based basket‐type clinical trial: BELIEVE Trial
Authors: Ando Yayoi , Shimoi Tatsunori , Sunami Kuniko , Okita Natsuko , Nakamura Kenichi , Shibata Taro , Fujiwara Yasuhiro , Yamamoto Noboru 
Published: December 2023

AbstractCancer genomic medicine using next‐generation sequencers has been developing. However, the number of patients who could receive genomically matched therapy is limited because off‐label use or patient‐oriented compassionate use was not permitted under National Health Insurance in Japan. To improve patient drug accessibility, we initiated a biomarker‐based basket‐type clinical trial (NCCH1901) in October 2019 under patient‐proposed healthcare services. We listed the drugs that had high medical needs but were not covered by National Healthcare Insurance. Then we included these drugs before patient proposal so that they could access off‐label drugs soon after they had the results of CGP tests. All drugs were provided free of charge by pharmaceutical companies. The objective was to administer off‐label drugs and to collect efficacy and safety data for these drugs. The primary endpoint was the response rate based on the best overall response for up to 16 weeks. As of January 31, 2022, we included 18 drug cohorts and 295 patients were treated in this study. The most common cancer was brain tumor, followed by carcinoma of endocrine organs and colorectal cancer. BRAF mutations and ERBB2 amplifications were the frequent genomic abnormalities to be enrolled. This study was one way to access off‐label drugs, and contributed significantly to providing treatment opportunities for patients in Japan.
The outsider within: The agentic practices of Family Group Conference coordinators in the context of families with children at risk
Authors: Shaibe Jordan , Shemer Orna 
Published: December 2023

AbstractFamily Group Conference (FGC) is a participatory decision‐making process for families with children at risk, for whom concerns were recognized by the family, the professionals and/or the community. In its initial stages, FGC is organized, and the families are accompanied, by independent coordinators. The study used a qualitative, action‐oriented methodology to explore what practices coordinators use to foster FGC's family‐led dynamic. The data collection included 13 semi‐structured, in‐depth interviews and two research group discussions with coordinators to learn about their perspectives and practices. The study found that these practices were guided by three main principles of action: to affirm the family's control and responsibility, to highlight the family's ability and to orient the family towards the future. The article explores how these practices contribute to the family‐led dynamic of FGC and situates them within the context of the welfare system and the positioning of the coordinators as ‘outsiders‐within’ to both the family and the welfare services. This study contributes to the body of knowledge on participatory child welfare models and agentic practices and offers implications for policy and implementation of FGC in a manner that recognizes and respects families' agency.
Pancreatic steatosis is an independent risk factor for post‐transplant diabetes mellitus in kidney transplant patients
Authors: Hasbal Nuri Baris , Copur Sidar , Peltek Ibrahim B. , Mutlu Ali , Atalay Hande Ozen , Kesgin Yavuz E. , Karakaya Afak Durur , Siriopol Dimitrie , Koçak Burak , Kanbay Mehmet 
Published: December 2023

AbstractBackground and AimPost‐transplant diabetes mellitus (PTDM) is associated with an increased risk of post‐transplant cardiovascular diseases, and several risk factors of PTDM have been shown in the literature. Yet, the relationship between hepatic and pancreatic steatosis with post‐transplant diabetes mellitus remains vague. We aimed to evaluate pancreatic steatosis, a novel component of metabolic syndrome, and hepatic steatosis association with post‐transplant diabetes mellitus in a single‐center retrospective cohort study conducted on kidney transplant recipients.MethodWe have performed a single‐center retrospective cohort study involving all kidney transplant recipients. We have utilized pretransplant Fibrosis‐4, nonalcoholic fatty liver disease fibrosis score, and abdominal computed tomography for the assessment of visceral steatosis status.ResultsWe have included 373 kidney transplant recipients with a mean follow‐up period of 32 months in our final analysis. Post‐transplant diabetes mellitus risk is associated with older age (p < .001), higher body‐mass index (p < .001), nonalcoholic fatty liver disease‐fibrosis score (p = .002), hepatic (p < .001) or pancreatic (p < .001) steatosis on imaging and higher pre‐transplant serum triglyceride (p = .003) and glucose levels (p = .001) after multivariate analysis.ConclusionOur study illustrates that recipients’ pancreatic steatosis is an independent predictive factor for post‐transplant diabetes mellitus including in kidney transplant patients.
Predictability of human exposure by human‐CYP3A4‐transgenic mouse models: A meta‐analysis
Authors: Damoiseaux David , Schinkel Alfred H. , Beijnen Jos H. , Huitema Alwin D. R. , Dorlo Thomas P. C. 
Published: December 2023

AbstractFirst‐in‐human dose predictions are primarily based on no‐observed‐adverse‐effect levels in animal studies. Predictions from these animal models are only as effective as their ability to predict human results. To narrow the gap between human and animals, researchers have, among other things, focused on the replacement of animal cytochrome P450 (CYP) enzymes with their human counterparts (called humanization), especially in mice. Whereas research in humanized mice is extensive, the emphasis has been particularly on qualitative rather than quantitative predictions. Because the CYP3A4 enzyme is most involved in the metabolism of clinically used drugs, most benefit was expected from CYP3A4 models. There are several applications of these mouse models regarding in vivo CYP3A4 functionality, one of which might be their capacity to help improve first‐in‐human (FIH) dose predictions for CYP3A4‐metabolized drugs. To evaluate whether human‐CYP3A4‐transgenic mouse models are better predictors of human exposure compared to the wild‐type mouse model, we performed a meta‐analysis comparing both mouse models in their ability to accurately predict human exposure of small‐molecule drugs metabolized by CYP3A4. Results showed that, in general, the human‐CYP3A4‐transgenic mouse model had similar accuracy in the prediction of human exposure compared to the wild‐type mouse model, suggesting that there is limited added value in humanization of the mouse Cyp3a enzymes if the primary aim is to acquire more accurate FIH dose predictions. Despite the results of this meta‐analysis, corrections for interspecies differences through extension of human‐CYP3A4‐transgenic mouse models with pharmacokinetic modeling approaches seems a promising contribution to more accurate quantitative predictions of human pharmacokinetics.
Performance of handheld ultrasound devices in diagnosis of pulmonary hypertension and right heart dysfunction in ICU patients
Authors: Dayıoğlu Mürüvvet , Gürsel Gül , Özercan Seçil , Aydın Eda Macit , Nadastepe Özge 
Published: December 2023

AbstractAimThe use of handheld ultrasonography devices (HHUD) has increased recently but there are limited data about their performance in the evaluation of right heart dysfunction (RHD) and pulmonary hypertension (PHT). The aim of the study is to compare the performance of a HHUD with a conventional ultrasound device (CUD) in assessing PHT and RHD.MethodsThis single‐center prospective study was performed in a seven‐bed teaching hospital intensive care unit (ICU). PHT and RHD criteria were compared by HHUD and CUD. Additional PHT criteria and right ventricle (RV) systolic and diastolic dysfunction criteria were also measured.ResultsForty‐six patients were included in the study. There was no significant difference between the imaging rates and mean values of the parameters measured by both devices. When the positivity rates for additional PHT parameters and RHD criteria were compared, there were no significant differences between the devices. In Bland‐Altman's analysis, there was good agreement and there was no bias between the measurements of the two devices but left ventricular end‐systolic eccentricity index (LVSEI), right atrium area (RAA), and pulmonary artery diameter (PAD). Ninety percent of the patients had PHT probability, of whom 43% had a low, 37% had intermediate and 10% had a high probability of PHT. Ninety‐two percent of the patients had RHD and there was no significant difference between the devices in the diagnosis of RHD (p = .212). When RV systolic and diastolic dysfunction evaluations of the devices were compared according to the British Society of Echocardiography (BSE) criteria there was no significant difference between the devices’ measurements in the evaluation of systolic and diastolic function.ConclusionThe imaging and measurement capabilities of the HHUDs for PHT and RHD parameters were similar to CUDs, and considering the inconsistent parameters, the HHUD can be useful in diagnosing these problems.
“Long GFC”? The global financial crisis, health care, and COVID‐19 deaths
Authors: Moreno Antonio , Ongena Steven , Ventula Veghazy Alexia , Wagner Alexander F. 
Published: December 2023

AbstractDo financial crises affect long‐term public health? To answer this question, we examined the relationship between the 2007–2009 Global Financial Crisis (GFC) and the 2020–2022 COVID‐19 pandemic. Specifically, we examined the relationship between the financial losses derived from the GFC, and the health outcomes associated with the first wave of the pandemic. European countries that were more affected by the financial crisis had more deaths relative to coronavirus cases. An analogous relationship emerged across Spanish provinces and US states. Part of the transmission from finances to health outcomes appears to have occurred through cross‐sectional differences in health care facilities.
Let's give a voice to young soil researchers
Authors: Panagos Panos , Orgiazzi Alberto 
Published: December 2023

AbstractYoung soil researchers represent a generation that will respond to future soil challenges and implement connected policy developments. They will deal with emerging challenges and opportunities for soil protection, such as climate change, land use change, scenario analysis, big data, modelling integration, one health aspects, and soil living laboratories. In this context, the EU Soil Observatory (EUSO) provides an inclusive forum for participatory research in the EU and beyond. In 2021, at the first gathering of the EUSO Stakeholders Forum, young researchers were actively engaged through the establishment of the EU Young Soil Researchers Forum. This resulted in interesting presentations, discussions, and research outputs, which have been brought together in this virtual thematicissue. Similar support for young soil researchers is expected at the 2024 EUSO Stakeholders Forum.
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy
Authors: d'Orio Piergiorgio , Squarza Silvia , Revay Martina , Cardinale Francesco , Castana Laura , Sartori Ivana , Tassi Laura , Lo Russo Giorgio , Cossu Massimo 
Published: December 2023

AbstractObjectiveThe objective of this study was to identify risk factors associated with surgery‐related neurological morbidity in patients with drug‐resistant epilepsy undergoing suprasylvian operculoinsular resections. As secondary outcomes, we also analyzed the risk factors for ischemic lesion (IL) of corona radiata and seizure recurrence.MethodsA retrospective analysis was conducted on a cohort of patients who underwent suprasylvian operculoinsular resections for drug‐resistant epilepsy. The association of several presurgical, surgical, and postsurgical factors with both primary (persistent neurological deficits) and secondary (structural abnormalities on postoperative magnetic resonance imaging [MRI] and seizure recurrence) postoperative outcomes was investigated with univariate and multivariate statistical analysis.ResultsThe study included a total of 65 patients; 46.2% of patients exhibited postoperative neurological deficits, but only 12.3% experienced persistent deficits. On postoperative MRI, IL in the corona radiata and corticospinal tract Wallerian degeneration (CSTWd) were seen in 68% and 29% of cases, respectively. Only CSTWd was significantly associated with persistent neurological deficits (relative risk [RR] = 2.6). Combined operculoinsular resection (RR = 3.62) and surgery performed on the left hemisphere (RR = .37) were independently associated with IL in the corona radiata. Variables independently associated with CSTWd were the presence of malacic components in the IL (RR = 1.96), right central operculum resection (RR = 1.79), and increasing age at surgery (RR = 1.03). Sixty‐two patients had a postoperative follow‐up > 12 months (median = 56, interquartile range = 30.75–73.5), and 62.9% were in Engel class I at last outpatient control. The risk of seizure recurrence was reduced by selective opercular resection (RR = .25) and increased by the histological diagnosis of aspecific gliosis (RR = 1.39).SignificanceThis study provides insights into the risk factors associated with surgery‐related neurological morbidity, as well as further evidence on the postoperative occurrence of subcortical injury and seizure recurrence in epileptic patients undergoing suprasylvian operculoinsular resections. The findings highlighted in this study may be useful to better understand the processes supporting the increased surgical risk in the operculoinsular region.
The long‐term outcomes of standing superficial keratectomy as the sole treatment of corneal B‐cell lymphoma in five horses in the UK: Clinical, histopathology, immunohistochemical and molecular findings
Authors: De Oliveira Francesca , Scurrell Emma J. , Dixon Samantha , Lowe Rob 
Published: December 2023

SummaryThis case report describes five horses with solitary corneal B‐cell lymphoma treated with superficial keratectomy as a sole treatment and their long‐term follow‐up. All five cases had a presumed clinical diagnosis of immune‐mediated keratitis (IMMK) which was initially responsive to immunosuppressive or immunomodulatory treatment. Between 6 and 71 months from the start of clinical disease, these cases became refractory to treatment. All five horses underwent superficial keratectomy under standing sedation and regional anaesthesia. A focal superficial keratectomy was performed in one horse to remove the affected area, and in the remaining four horses, the superficial cornea was removed in its entirety. Histopathology, immunohistochemistry (IHC) and polymerase chain reaction for antigen receptor rearrangements (PARR testing) were performed on all five keratectomy specimens. The histopathological and immunohistochemical findings indicated a florid stromal infiltrate of mitotically active, intermediate to large B‐lymphocytes amidst a variable background of chronic keratitis. In three of the five cases, the lymphocytes displayed prominent epitheliotropism. PARR testing confirmed rearrangements of, specifically, IGH2, IGH3 and KDE, indicating B‐cell clonal expansion consistent with B‐cell lymphoma. There has been no local recurrence in any of the five horses over 24–84 months of follow‐up and no clinical evidence of multicentric lymphoma. No adjunctive treatment was given post‐keratectomy and all eyes have remained comfortable and off treatment. Results of this report show that standing superficial keratectomy is a viable diagnostic tool and a long‐term treatment option for diffuse intermediate to large corneal B‐cell lymphoma.
3D numerical analysis of stability and onset of hydraulic fracture in the vertical‐oblique‐horizontal wells under wide range of in situ stresses
Authors: Shan Zhigang , Zhao Liuyuan , Ni Weida , Wu Jie , Zhang Fang , Aliha M. R. M. 
Published: December 2023

AbstractInfluence of the depth and location of perforation, direction and magnitudes of in situ stresses, wellbore angle, and pumping pressure is investigated numerically for the hydraulic fracture. 3D models of rock formation with vertical, inclined or horizontal wells containing semi‐circular crack are analyzed to obtain both KI and the minimum pumping pressure. By computing the magnitude and sign of the T‐stress it is demonstrated that hydraulic fracture path is generally stable except for a very limited situations in which the vertical well is subjected to the lowest in situ stresses. The minimum horizontal in situ stress has the most dominant role in controlling the hydraulic fracture. A direct relationship between KI and T was obtained for different ranges of in situ stresses and some relations were presented for estimating the critical stress intensity factor at the onset of hydraulic fracture and minimum injection pressure in terms of the applied in situ stresses.
The role of roasting on changes in bioactive properties, fatty acid and phenolic compound profiles in the free and bound fraction of black quinoa seeds
Authors: Mohamed Ahmed Isam A. , Özcan Mehmet Musa , Uslu Nurhan , Mohammed Belal M. , Adiamo Oladipupo 
Published: December 2023

SummaryIn present investigation, the effect of roasting in microwave and oven on bioactive compounds, antioxidant capacity, fatty acid profiles and phenolic constituents of quinoa seeds for free and conjugated phenolic profile fractions are studied. The oil contents of seeds roasted in both roasting systems were recorded between 4.25% (microwave) and 4.80% (oven).Total phenolic amounts of free and bound fractions of quinoa seeds were measured to be between 1668.1 (control) and 2037.5 mg/100 g (microwave) to 638.9 (microwave) to 1615.3 mg/100 g (oven), respectively. Antioxidant activities of free and bound fractions of quinoa seeds were recorded to be between 36.86% (microwave) and 39.28% (oven) to 74.83% (control) and 77.18% (microwave), respectively. Oleic and linoleic acid results of quinoa seed oils roasted in microwave and oven were identified between 17.26% (oven) and 22.41% (control) to 48.39% (oven) and 59.92% (microwave), respectively. 3,4‐Dihydroxybenzoic acid results of raw and roasted quinoa seeds for free and bound fractions were identified to be between 2.84 (microwave) and 4.01 mg/100 g (oven) to 7.43 (oven) and 12.60 mg/100 g (control), respectively. K results of roasted quinoa seeds were recorded between 8701.17 (oven) and 9638.45 (microwave). Results showed some changes depending on roasting systems and fraction types.
Tuning the thermal and insulation properties of bismuth borate glass for SiC power electronics packaging
Authors: Chen Junwei , Chen Wei , Zhang Liangzhu , Yan Xuyang , Fan Jiajie , Zeng Huidan 
Published: December 2023

AbstractSilicon carbide (SiC) power devices are attracting significant attention due to their outstanding stability in high‐voltage, high‐temperature, and high‐frequency environments. To replace toxic Pb‐based glass, there is an urgent need to develop Pb‐free glass for SiC power device encapsulation, considering its superior electrical insulation properties and processing capabilities. Here, we developed a Bi‐based glass for effective encapsulation practical of SiC power devices. By increasing the content of glass modifier BaO, the structure of bismuth borate glass can be tuned to reduce glass network density, leading to the transition of structural units from [BO4] to [BO3]. The softened temperature is reduced to 363.4°C with the BaO content increasing to 15 mol%. After encapsulating the SiC power devices using Bi‐based glass, the glass demonstrated a reverse breakdown voltage of 650 V and an extremely low leakage current. Therefore, our work provided a route for adapting Pb‐free‐based low‐melting glass for encapsulating SiC devices and offered potential for advanced semiconductor packaging.
Parental presence, participation, and engagement in paediatric hospital care: A conceptual delineation
Authors: Harlow Ashleigh B. , Ledbetter Leila , Brandon Debra H. 
Published: December 2023

AbstractAimTo delineate between the concepts of parental presence, participation, and engagement in paediatric hospital care.DesignThe concepts' uses in the literature were analysed to determine attributes, influences, and relationships.MethodsDelineations of each concept are established and conceptual definitions are proposed following Morses' methods.Data SourcesMEDLINE (PubMed); CINAHL, PsycINFO, Sociology Source Ultimate (EBSCOhost); Embase, Scopus (Elsevier); Google Scholar. Search dates October 2021, February 2023.ResultsMultinational publications dated 1991–2023 revealed these concepts represent a range of parental behaviours, beliefs, and actions, which are not always perceptible to nurses, but which are important in family‐integrated care delivery. Parental presence is the state of a parent being physically and/or emotionally with their child. Parental participation reflects parents' performing caregiving activities with or without nurses. Parental engagement is a parents' state of emotional involvement in their child's health and the ways they act on their child's behalf.ConclusionThese concepts' manifestations are important to parental role attainment but may be inadequately understood and considered by healthcare providers.ImplicationsNurses have influence over parents' parental presence, participation, and engagement in their child's care but need support from healthcare institutions to ensure equitable family‐integrated care delivery.ImpactProblem: Lack of clear definition among these concepts results in incomplete and at times inequitable family‐integrated care delivery. Findings: Parental presence is an antecedent to parental participation, and parental presence and participation are elements of parental engagement. The concepts interact to influence one another. Impact: Hospitalized children, their families, nurses, and researchers will benefit through a better understanding of the concepts' attributes, interactions, and implications for enhanced family‐integrated care delivery.