bluuebunny/crossref_metadata_2025_split huggingface dataset:
HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation duringDrosophilaoogenesis
Authors: Xu Fengmei , Suyama Ritsuko , Inada Toshifumi , Kawaguchi Shinichi , Kai Toshie 
Published: January 2024

AbstractHemK2 is a highly conserved methyltransferase spanning from yeast to humans. Despite its conservation, the identification of its genuine substrates has been controversial, and its biological importance in higher organisms remains unclear. In this study, we elucidate the role of HemK2 in the methylation of eukaryotic Release Factor 1 (eRF1), a process essential for female germline development inDrosophila melanogaster. Knockdown ofhemK2in the germline cells (hemK2-GLKD) induces apoptosis in these cells, accompanied by a pronounced decrease in both eRF1 methylation and protein synthesis. The overexpression of a methylation-deficient eRF1 variant recapitulates the defects observed inhemK2-GLKD, suggesting that eRF1 is a primary methylation target of HemK2. Furthermore,hemK2-GLKD leads to significant reduction mRNA levels in germline cell. We demonstrate that these defects in oogenesis and protein synthesis can be partially restored by inhibiting the No-Go Decay pathway. In addition,hemK2knockdown is associated with increased disome formation, suggesting that disruptions in eRF1 methylation may provoke ribosomal stalling, which subsequently activates translation-coupled mRNA surveillance mechanisms that degrade actively-translated mRNAs. We propose that HemK2-mediated methylation of eRF1 is critical for ensuring efficient protein production and mRNA stability, which are vital for the generation of high-quality eggs.
How does COVID-19 distort the impact of information interventions on low-carbon diet transitions: a case of dairy consumption in China
Authors: Zhou Li , Su Zifan , Lei Lei , Wei Zheng 
Published: January 2024

PurposeThis paper examines the impact of the COVID-19 pandemic on low-carbon consumption of dairy products through informational interventions. The empirical findings seek to enlighten developing countries' efforts in coping with climate change and potential dietary transitions.Design/methodology/approachA randomized controlled trial was designed to examine the effects of purpose-differentiated information interventions on individual dairy consumption. The experiment recruited and randomly assigned 1,002 college students into four groups to receive (or not) environmental or/and health information interventions.FindingsThe empirical analysis finds that health and combined information interventions have a positive impact on dairy consumption, while environmental information interventions' effect on dairy consumption is insignificant. In the context of the pandemic, health information interventions positively affected participants' perceptions and preferences for dairy products by delivering knowledge about their role in boosting immunity. However, environmental information interventions failed to do the same things as their insignificant effects on both perception and preference.Originality/valueMacro-external shocks, such as public health events, may offset the impact of universal information interventions promoting pro-environmental behaviors. For a smooth dietary transition to achieve long-term environmental sustainability, diverse stakeholders must be included in more individualized interventions to guide daily consumption, especially in developing countries with large populations.
Assessing project criticality in project portfolio: a vulnerability modeling approach
Authors: Bai Libiao , Xie Xiaoyan , Sun Yichen , Qu Xue , Han Xiao 
Published: January 2024

PurposeAssessing project criticality in a project portfolio (PP) is of great practical significance to improve robustness from damage. While project criticality assessment has increased diversity in approaches, the understanding of vulnerable project impacts is still limited. To promote a better understanding of assessing project criticality, a vulnerability measurement model is constructed.Design/methodology/approachFirst, integrating the tasks, projects and corresponding relationships among them, a project portfolio network (PPN) is constructed. Second, the project's vulnerability is measured by combining the topological structure and functional attributes. Third, project criticality is assessed by the vulnerability measurement results. Lastly, the proposed model is applied in a numerical example to illustrate its suitability and effectiveness.FindingsFor academia, this study provides a novel perspective on project vulnerability measurement and expands project criticality assessment tools. For practitioners, the straightforward model provides an effective tool for assessing project criticality and contributes to enhancing project portfolio management (PPM).Originality/valueThe impact of the task on the project is considered in this study. Topological structure and functional attributes are also integrated for measuring project vulnerability due to the impact of random attacks in an uncertain environment, providing a new perspective on the requirements of project criticality assessment and the measurement of project vulnerability.
Cross-border mergers and acquisitions from emerging economy firms: a new channel for technology augmentation
Authors: Hong Eunsuk , Shin Jong-Kook , Zou Huan 
Published: January 2024

Purpose
Extending the springboard perspective with the resource dependence theory, the authors posit that cross-border mergers and acquisitions (M&As) are a new channel for emerging economy firms (EEFs) to enhance their technology capabilities. This study aims to examine the impact of cross-border M&As initiated by EEFs on their technology augmentation vis-à-vis matched domestic M&A cases and investigate the factors influencing the difference in post-merger innovation capability.

Design/methodology/approach
This paper estimates the post-acquisition innovation capability of acquirers from emerging economies (EEs) that engage in cross-border M&As. To remove possible selection bias, the authors leverage a difference-in-difference-style approach in combination with a matched sample constructed by pairing each cross-border M&A case with a similar domestic deal. The data set contains 266 cross-border M&As and 266 matched domestic M&A deals between 2003 and 2011, whereby acquirers are based in 6 EEs and targets are in 36 countries consisting of both EEs and advanced economies (AEs).

Findings
The present empirical results show that cross-border M&As engaged by EEFs are an important engine for improving EEFs’ innovation capability through technology augmentation. The main empirical results are as follows. First, compared with matched domestic acquirers with similar characteristics, EE cross-border M&As have a positive effect on innovation capability. Second, the positive effect of the EEFs’ cross-border M&As relative to the matched domestic M&As on innovation capability is driven largely by cross-border M&As with targets in AEs. Third, the increase in post-M&A innovation capability of the EE cross-border acquirers comes mainly from deals where targets are based in countries with relatively superior human capital and innovation capability than those of the acquirers.

Originality/value
To the best of the authors’ knowledge, this study is the first systematic study of whether cross-border M&As serve as an effective channel of technology augmentation for EE acquirers compared to matched domestic acquirers with similar characteristics.
Public servants’ political activity online in an institutional environment of caution: the role of personality traits
Authors: Cooper Christopher A. 
Published: January 2024

PurposeAs social media has become an ingrained aspect of our lives—including our political relationships with other citizens and the state—various governments have warned public servants that being politically active online might threaten the reputed impartiality of themselves and the public service. This study examines whether public servants are less likely to be politically active on social media than other citizens, and seeks to understand public servants’ varying disposition to be politically active online by investigating the role of employees’ underlying Big 5 personality traits.Design/methodology/approachMultivariate regression, along with marginal effects and predicted probabilities, are used to investigate public servants’ online political activity with survey data from Canada, a country where impartiality is a core public service value, and where governments, public service commissions and even public sector unions have voiced cautious messages about the threat online political activity presents to the reputed impartiality of public servants, and the public service at large.FindingsAnalysis of the direct effects of being a public servant and each Big 5 personality trait finds that being a public servant significantly, and substantively, reduces the probability of engaging in online political activity, meanwhile, Extraversion and Conscientiousness have consistent, significant and substantive relationships with being politically active online. Subsequent analysis investigating the dynamic between the Big 5 and being a public servant, uncovers a more complex story. Among public servants, Openness and Neuroticism, rather than Extraversion and Conscientiousness, are associated with significant and substantive changes in the probability of engaging in some online politically activities. This is consistent with research investigating the relationship between the Big 5 and risk aversion, given that public servants in Canada work in an environment with a highly cautious discourse portraying social media as a serious risk to impartiality.Practical implicationsThe findings also speak to best practices for public service human resource managers by shedding light how public servants’ behavior can be better understood and managed by paying attention to their underlying personality traits.Originality/valueThis study moves beyond analyzing trends between public and private sector employees, to instead examine public servants’ online political activity. This study offers theoretical and empirical insight into how public servants’ disposition to be politically active online is, in part, influenced by their underlying Big 5 personality traits, specifically, Neuroticism and Openness.
Effect of consistency of the review set on causal attribution: the moderating roles of repeating purchase cues and product knowledge
Authors: Peng Xiao , Vali Hessam , Peng Xixian , Xu Jingjun (David) , Yildirim Mehmet Bayram 
Published: January 2024

PurposeThe study examines the potential moderating effects of repeating purchase cues and product knowledge on the relationship between the varying consistency of the review set and causal attribution. This study also investigates how causal attribution correlates with the perceived misleadingness of the review set.Design/methodology/approachA scenario-based experiment was conducted with 170 participants to explore the relationship between the consistency of the review set and causal attribution and how repeating purchase cues and product knowledge moderates this relationship.FindingsFindings suggest that inconsistent review sets lead to more product (vs reviewer) attribution than consistent review sets. The repeating purchase cues mitigate the negative relationship between the consistency of the review set and product attribution, whereas product knowledge mitigates the positive relationship between the consistency of the review set and reviewer attribution. Furthermore, the results indicate that high product attribution and low reviewer attribution are associated with low perceived misleadingness.Originality/valueThis study is novel because it examines the moderating effects of repeating purchase cues and product knowledge on the relationship between the consistency of the review set and causal attribution. It adds to the literature by shedding light on the causal attribution process underlying the formation of perceived misleadingness of online reviews. The findings of this study provide valuable insights for managers on how to enhance the positive effects of consistent review sets and mitigate the negative effects of inconsistent review sets.
A performance management framework for smart health-care supply chain based on industry 4.0 technologies
Authors: Hossain Md Kamal , Thakur Vikas 
Published: January 2024

Purpose
The study aims to envisage upon conceptualizing and developing the scales of smart health-care supply chain (HCSC) performance in the era of the fourth industrial revolution.

Design/methodology/approach
This study has implemented structural equation modelling to analyse the survey data. To analyse the collected data from the field investigation involving a sample size of 323, the IBM SPSS AMOS 26 software package is considered to implement exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) in this study.

Findings
The measurement model of the study developed using EFA and CFA has resulted in validating 32 items out of the 42 items. Resultantly, the analysis using the above-mentioned tools and the parsimony of items to scale development makes it more susceptible to contributing significantly to the current HCSC literature.

Research limitations/implications
The HC providers need to consider a holistic and systematic approach while taking into account the constructs of smart HCSC performance, specifically, the effect of HCSC responsiveness and industry 4.0 between the independent and dependent variables. The scales are validated from the perspectives of developing countries such as India, and hence, their generalizability with respect to first-world countries is practically limited.

Originality/value
The scales validated in this study would facilitate managers and key decision-makers to apply the various elements of HCSC practices, gauge the application of these scales and monitor the performance of health-care facilities.
Place and avoiding the race to the bottom of the fractured well
Authors: Pearson John 
Published: January 2024

Purpose
This paper aims to consider the potential implications of the layering of regulation in relation to hydraulic fracturing (fracking) at the borders between the nations of the UK.

Design/methodology/approach
This paper uses a qualitative research method grounded in particular in legal geography to examine the existing approaches to regulating hydraulic fracturing and identify the places and their features that are constructed as a result of their intersection at the borders of the nations comprising the UK.

Findings
The current regulatory framework concerning hydraulic fracturing risks restricts the places in which the practice can occur in such a manner as to potentially cause greater environmental harm should the process be used. The regulations governing the process are not aligned in relation to the surface and subsurface aspects of the process to enable their management, once operational, as a singularly constructed place of extraction. Strong regulation at the surface can have the effect of influencing placement of the site only in relation to the place at which the resource sought reaches the surface, whilst having little to no impact on the environmental harms, which will result at the subsurface or relative to other potential surface site positions, and potentially even increasing them.

Research limitations/implications
This paper is limited by uncertainty as to the future use of hydraulic fracturing to extract oil and gas within the UK. The issues raised within it would also be applicable to other extractive industries where a surface site might be placed within a radius of the subsurface point of extraction, rather than having to be located at a fixed point relative to that in the subsurface. This paper therefore raises concerns that might be explored more generally in relation to the regulation of the place of resource extraction, particularly at legal borders between jurisdictions, and the impact of regulation, which does not account for the misalignment of regulation of spaces above and below the surface that form a single place at which extraction occurs.

Social implications
This paper considers the potential impacts of misaligned positions held by nations in the UK in relation to environmentally harmful practices undertaken by extractive industries, which are highlighted by an analysis of the extant regulatory framework for hydraulic fracturing.

Originality/value
Whilst the potential for cross internal border extraction of gas within the UK via hydraulic fracturing and the regulatory consequences of this has been highlighted in academic literature, this paper examines the implications of regulation for the least environmentally harmful placement of the process.
Platform financing and CSR performance in an E-commerce marketplace
Authors: Phan Dinh Anh , Vo Thi Le Hoa 
Published: January 2024

PurposeThis paper investigates whether and how the financial services offered by an e-commerce platform can help budget-constrained small- and medium-sized suppliers improve their corporate social responsibility (CSR) performance.Design/methodology/approachThe authors examine a supply chain in which a budget-constrained supplier engages in CSR, produces a finished product and sells it on the marketplace of an e-commerce platform. This platform offers financial services to the supplier, choosing among three types of financing models: target rate of return, credit limit and CSR-linked financing. Using a Stackelberg game approach, the authors can drive the equilibrium decisions under each financing model.FindingsThe results reveal that all three financing models help improve the supplier's CSR investment as long as consumer sensitivity toward CSR exists. Moreover, the last one leads to the highest profitability of the overall supply chain and each member.Originality/valueThe findings shed light on the role of platform financing and how to design the most appropriate financing model to improve CSR for supply chain managers.
Prioritizing dark patterns in the e-commerce industry – an empirical investigation using analytic hierarchy process
Authors: Singh Vibhav , Vishvakarma Niraj Kumar , Mal Hoshiar , Kumar Vinod 
Published: January 2024

Purpose
E-commerce companies use different types of dark patterns to manipulate choices and earn higher revenues. This study aims to evaluate and prioritize dark patterns used by e-commerce companies to determine which dark patterns are the most profitable and risky.

Design/methodology/approach
The analytic hierarchy process (AHP) prioritizes the observed categories of dark patterns based on the literature. Several corporate and academic specialists were consulted to create a comparison matrix to assess the elements of the detected dark pattern types.

Findings
Economic indicators are the most significant aspect of every business. Consequently, many companies use manipulative methods such as dark patterns to boost their revenue. The study revealed that the revenue generated by the types of dark patterns varies greatly. It was found that exigency, social proof, forced action and sneaking generate the highest revenues, whereas obstruction and misdirection create only marginal revenues for an e-commerce company.

Research limitations/implications
The limitation of the AHP study is that the rating scale used in the analysis is conceptual. Consequentially, pairwise comparisons may induce bias in the results.

Practical implications
This paper suggests methodical and operational techniques to choose the priority of dark patterns to drive profits with minimum tradeoffs. The dark pattern ranking technique might be carried out by companies once a year to understand the implications of any new dark patterns used.

Originality/value
The advantages of understanding the trade-offs of implementing dark patterns are massive. E-commerce companies can optimize their spent time and resources by implementing the most beneficial dark patterns and avoiding the ones that drive marginal profits and annoy consumers.
A systematic review of the CPTED–quality of life relationship
Authors: Songole Hillary Shiverenje 
Published: January 2024

Purpose
CPTED’s premise to the improvement of quality of life (QOL) is crime prevention and safety, and yet there is little concern for the impact of CPTED implementation to QOL when the crime increases after the interventions.

Design/methodology/approach
This study systematically analyzed articles both quantitatively and qualitatively.

Findings
This study found that the CPTED–QOL relationship discussion was highly inadequate in research. Improvement of QOL has been elevated to an unquestionable and certain truth of CPTED and yet the evidence on this is highly inconclusive.

Originality/value
This study is a contribution to the CPTED–QOL discussion that has been lacking.
Receipt survey of prescription continuation rates for patients with onychomycosis and web‐based survey of dermatologists on prescribing policies for onychomycosis therapeutics
Authors: Tsunemi Yuichiro , Otsuka Atsushi , Nonaka Yusuke 
Published: January 2024

AbstractOnychomycosis can be treated with topical and oral medications. However, it is important to appropriately select these medications according to the type and severity of the disease and ensure treatment is continued for the recommended duration. In Japan, treatment options for onychomycosis have increased in recent years. Moreover, in 2019, the guidelines for dermatomycosis treatment were revised. In this study, we conducted a receipt survey to clarify the actual treatment status of onychomycosis cases as indicated by the continuation rates of prescribed treatment drugs, together with a web‐based survey to ascertain the prescribing policy of dermatologists regarding drugs for onychomycosis treatment. In agreement with past surveys, this receipt survey showed that the prescription continuation rate for oral medications was higher than that for topical medications. The 1‐year prescription continuation rate for topical onychomycosis medications was found to be low (<10%). The web‐based survey showed that the percentage of physicians who prescribed oral medications as their first choice increased by approximately 10% for each disease type, compared with the results of the previous survey conducted around 7 years ago. However, the study also confirmed that topical drugs are still prescribed for some disease types for which oral drugs are better suited. To ensure complete cure without patient drop‐out, oral drugs with a high probability of achieving complete cure and a high continuation rate should be prescribed for patients with onychomycosis.