bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of maltings microflora on malt quality
Authors: Stars A C , South J B , Smith N A 
Published: November 2023

Abstract
Variation in the pH of batches of malt can lead to inconsistent brewhouse performance, including inefficient removal of cold break and subsequent wort clarity problems. A major contributor to this variation is process-dependent fluctuation in the organic acid profile of the malt. These acids are found at all stages of malting and the pattern of their production is dependent upon both microbial and barley metabolism. This study demonstrates the interactions between grain environment and microbial populations during malting which govern final organic acid concentration. Kilning regime has been identified as a critical factor.
Practical experiences with immunological detection of Fusarium in barley and malt
Authors: Vaag Pia , Pedersen Stig 
Published: November 2023

Abstract
Immunological quantification of Fusarium metabolites has been used to evaluate Fusarium infection in Danish barley and development of the mold during storage and malting. The possibility of predicting gushing tendency in beer by determination of Fusarium antigens in barley and malt has also been investigated.
Developments in the evaluation of beer flavour
Authors: Hegarty P K , White F H 
Published: November 2023

Abstract
The application of quality systems such as ISO 9000 to tasting demands that flavour information can be shown to be repeatable and reliable. Computerised statistics packages are used to monitor the performance of every assessor for each flavour descriptor. This information is used for selection of panelists, panel monitoring and training. The Software is used to present information in a format that can be readily understood (eg. Principle Component Analysis, Spider Diagrams, etc.). Thus it is possible to “calibrate” the flavour profile panel analogous to the calibration of laboratory analytical instruments and present results that are highly reliable, easily understood and meet the business needs of today’s brewing industry.
Wort analysis by near-infrared spectroscopy
Authors: Sjöholm Katharina , Tenhunen Jussi , Home Silja , Pietilä Kirsti 
Published: November 2023

Abstract
Application of transmission near-infrared spectroscopy to the determination of glucose, maltose, maltotriose, nitrogen, free a-amino nitrogen and B-glucans in wort was studied. NIR spectra of traditional and high gravity worts were scanned at 1200-2400 nm. NIR spectroscopy was also used for monitoring biochemical changes during mashing. Good calibrations for individual fermentable sugars and for the sum of fermentable sugars were obtained with the PLS calibration method. Calibrations for process control purposes were developed for nitrogen and free a-amino nitrogen. Since no sample preparation other than filtration was required, the technique provided a rapid method for determination of wort quality.
Validation
Authors: O’Fegan Peter 
Published: November 2023

Abstract
In the past three decades, RIA systems have diversified to give microtitre plate enzyme-immunoassays, time-resolved immunofluorimetric assays, automated random access immunoanalysers and single-step qualitative immunotests that are usable by members of the general public. To be acceptable to end users, all must be validated and these validation criteria are to a large extent independent of test format. Validation criteria revolve around the key concepts of precision and accuracy.
However, with respect to many important details, how assay validity may be demonstrated depends on the analyte in question and on its chemical nature. When the analyte is available in highly pure form and is chemically definable, a true reference method may be available and the validation procedure may be more rigorous and straight-forward in many respects. However the analyte may be a specific antibody, be biochemically poorly characterized, genetically variable, biologically or chemically glycosylated to various degrees or exist in different forms owing to partial denaturation and partial hydrolysis (e.g. peptide nicking). In many such cases, validation procedures may be peculiar to the kind of analyte in question but they all would adhere to the principles outlined in this chapter.
The green fluorescent protein(GFP) as reporter in plant cells
Authors: Neuhaus Jean-Marc , Boevink Petra 
Published: November 2023

Abstract
Reporter proteins are an important tool in the study of gene expression in bacteria and eukaryotes. Their advantage resides in their easy and reproducible detection under standardized conditions in a large variety of organisms and cell types. The detection of most reporter proteins ( -galactosidase, -glucuronidase, luciferase) relies on the enzymatic production of a coloured, fluorescent, or luminescent product which then allows an easy quantification or localization. The advantage of enzymatic reporters resides in their sensitivity, as a single protein can produce abundant product molecules, while their disadvantage resides in the need to bring an artificial substrate into contact with the enzyme. This introduction may be differentially efficient in different tissues and may even require fixation and permeabilization of the tissue. The discovery of spontaneously fluorescent proteins that do not need extraneous fluorophores or substrates has permitted the study of the expression of genes and the localization of proteins in living cells, even in whole living organisms.
Long-Term Safety and Efficacy of Perfluorohexyloctane Ophthalmic Solution for the Treatment of Patients With Dry Eye Disease: The KALAHARI Study
Authors: Protzko Eugene E. , Segal Bruce A. , Korenfeld Michael S. , Krösser Sonja , Vittitow Jason L. 
Published: November 2023

Purpose:
The aim of this study was to assess the long-term safety and efficacy of perfluorohexyloctane (PFHO) ophthalmic drop (formerly NOV03) for treatment of dry eye disease (DED).

Methods:
KALAHARI was a phase 3, multicenter, single-arm, open-label extension study in patients aged 18 years or older with DED associated with Meibomian gland dysfunction who completed the randomized, double-masked, hypotonic saline-controlled GOBI study. Patients instilled 1 drop of PFHO (MIEBO, Bausch + Lomb) 4 times daily in both eyes for 52 weeks. Safety assessments included adverse events, best-corrected visual acuity, slit-lamp biomicroscopy, intraocular pressure, and dilated fundoscopy. Efficacy end points included change from GOBI study baseline in total corneal fluorescein staining and eye dryness score (0–100 visual analog scale).

Results:
Overall, 208 patients from GOBI (PFHO [n = 97]; saline [n = 111]) were rolled over into KALAHARI. Twenty-nine patients (13.9%) had ≥1 ocular adverse event, with most being mild or moderate in severity; the most common ocular adverse events were vitreous detachment (1.9%), allergic conjunctivitis (1.4%), blurred vision (1.4%), and increased lacrimation (1.4%). Other safety end points were unremarkable. For patients continuing PFHO from GOBI, improvements in total corneal fluorescein staining and visual analog scale dryness scores observed in GOBI were maintained throughout KALAHARI. Patients treated with saline in GOBI and switched to PFHO in KALAHARI showed improvements in total corneal fluorescein staining and visual analog scale scores by week 4 that were maintained for the rest of the study.

Conclusions:
PFHO was safe and well tolerated and maintained efficacy for improving signs and symptoms of DED in this year-long study of patients with DED associated with Meibomian gland dysfunction.
Implantation of Intracorneal Ring Segments in Keratectasia: Effects on Corneal Biomechanics in 112 Eyes
Authors: Hamon Loïc , Pfahl Luisa J. , Flockerzi Elias , Berger Tim , Langenbucher Achim , Seitz Berthold , Daas Loay 
Published: November 2023

Purpose:
The aim of this study was to analyze changes in corneal biomechanical properties after implantation of intracorneal ring segments (ICRSs) in keratectasia.

Methods:
This retrospective single-center study included 112 patient eyes that underwent femtosecond laser-assisted ICRS implantation (Intacs SK; Addition Technology Inc, Des Plaines, IL) for keratectasia. Biomechanical analysis was performed using the Ocular Response Analyzer (ORA; Reichert Inc, Depew, NY), with determination of corneal resistance factor, corneal hysteresis, and Keratoconus Match Index, as well as by Corvis ST (OCULUS, Wetzlar, Germany), with determination of stiffness parameter A1, Ambrosio relational thickness to the horizontal profile (Arth), integrated radius, deformation amplitude ratio, and stress–strain index as well as Corvis Biomechanical Index and Tomographic Biomechanical Index. Data collection was performed preoperatively and 6 months postoperatively for ORA and Corvis ST and additionally after 1 and 2 years for ORA.

Results:
The corneal resistance factor decreased significantly postoperatively (5.8 ± 1.7 mm Hg) compared with preoperatively (6.75 ± 3.7 mm Hg; P = 0.021) and increased again during follow-up (6.2 ± 1.9 mm Hg; P = 0.024), without regaining preoperative values. Corneal hysteresis and Keratoconus Match Index did not change significantly. Stiffness parameter A1 (P = 0.045) increased significantly after ICRS implantation and Arth decreased significantly from 181 ± 85 to 150 ± 92 (P = 0.016). However, there was no significant postoperative change for others Corvis parameters.

Conclusions:
Corneal biomechanical properties showed inconsistent changes after ICRS implantation. Classical corneal biomechanical parameters (using single central air-puff tonometers) do not seem to be suitable for follow-up after ICRS implantation.
Descemet Stripping Only: Long-Term Outcomes
Authors: Hakim Farida Esaa , Nagra Avneet Kaur , Dhaliwal Deepinder Kaur 
Published: November 2023

Purpose:
Descemet stripping only (DSO) is a relatively novel treatment for Fuchs endothelial corneal dystrophy (FECD). In this procedure, a central area of Descemet membrane and endothelium is removed without the insertion of donor tissue. Evaluation of long-term outcomes (≥5 years) after DSO is imperative to establish the validity of this procedure and to determine its role in the management of Fuchs endothelial dystrophy. Published outcomes are limited but promising. This study evaluates the 5- and 6-year outcomes of patients who had DSO at a single institution.

Methods:
This is a retrospective chart review of patients with FECD who underwent DSO in 2016 and 2017.

Results:
Eleven patients and 13 eyes met the criteria. Twelve of 13 eyes achieved corneal clearance. Two eyes had corneal decompensation requiring subsequent endothelial keratoplasty (EK). Of the 10 eyes that maintained clear corneas, 9 had a best-corrected visual acuity (BCVA) of at least 20/30 (mean logarithm of the minimim angle of resolution [logMAR] visual acuity [VA] 0.18 ± 0.16) at 5 years post-operatively (POY5). At 6 years, 7 of 8 eyes had a VA better than 20/40 (mean logMAR VA 0.17 ± 0.04). One patient had decreased VA due to progression of macular degeneration. Patients who required EK achieved good vision and corneal clearance.

Conclusions:
This is the largest series of patients with long-term follow-up after DSO. Ten of the 13 eyes (77%) responded and maintained clear central corneas for at least 5 years. Patients with failed DSO can achieve corneal clearance and good vision with subsequent EK. These patient outcomes support the role of DSO in the management of patients with FECD.
The cost of universal design for public buildings: exploring a realistic, context-dependent research approach
Authors: Ielegems Elke , Vanrie Jan 
Published: November 2023

PurposeA challenge in implementing Universal Design (UD) is the perceived additional cost, which acts as a barrier to its widespread adoption. The few studies that have examined the cost for UD apply a theoretical research approach, failing to account for the unique design context that influences construction costs. This article presents a research methodology to calculate the UD cost in a realistic, context-dependent manner.Design/methodology/approachTo address this gap, “Research-by-Design” is applied in a case study approach involving twelve cases from three typologies: secondary schools, town halls and small retail shops. Two scenarios are compared to the existing situation: (1) “renovating into a 100% inclusive building” and (2) “building fully inclusive right away”.FindingsAlthough the methodology is time-consuming, it allows for a fair, realistic and detailed comparison between costs in different scenarios and cases. Findings show how financial implications are strongly related to its scale. Both “renovation” and “new build” scenarios involve costs, but these are considerably lower for the latter. “Circulation” and “Exterior stairs and ramps” are among the most expensive to renovate, but have almost no additional cost in the examined cases for the “new build scenario”.Research limitations/implicationsThe research methodology presented in this study is time-consuming, which may limit its feasibility for large-scale cost assessments in diverse contexts.Practical implicationsThe research methodology proposed in this study provides valuable insights for architects, designers and stakeholders involved in the implementation of UD. It offers a realistic and context-dependent approach to assess the cost implications of UD, enabling informed decision-making during the design and construction phases.Social implicationsBy revealing the specific cost implications of UD in different building contexts, this study contributes to promoting greater accessibility and inclusion in the built environment.Originality/valueThe applied approach distinguishes this study for its ability to provide rich contextual information on actual cost implications for UD. By considering real cases and their unique design contexts, valuable insights are offered into the true costs of implementing UD in the built environment.
Cited by: automating citation counts for monographs using Google Scholar
Authors: Coughlin Daniel , Dudash Andrew , Gordon Jacob 
Published: November 2023

Purpose
The purpose of this paper is to investigate the feasibility of automating Google Scholar searching to harvest citation data of monographs for collection analysis.

Design/methodology/approach
This study discusses the creation and refinement of a Scraper application programming interface query structure created to match library collection inventories to their Google Scholar listings to retrieve citation counts.

Findings
This paper indicates that Google Scholar is a feasible and usable tool for retrieving monograph citation data.

Originality/value
This study shows that Google Scholar citation data can be harvested for monographs in an automated fashion to serve as a source of bibliographic data, something not typically done outside of individual academics and writers tracking their personal academic impact factors.
A hypothalamus‐habenula circuit regulates psychomotor responses induced by cocaine
Authors: Ahn Dan Bi , Jang Han Byeol , Ryu Yeonhee , Kim Hyung Kyu , Guan Xiaowei , Fan Yu , Lee Bae Hwan , Kim Hee Young 
Published: November 2023

AbstractAdministration of cocaine increases synaptic dopamine levels by blocking dopamine reuptake and leads to increased locomotor activity and compulsive drug‐seeking behaviour. It has been suggested that the lateral hypothalamus (LH) or lateral habenula (LHb) is involved in drug‐seeking behaviours. To explore the role of the LH and the LHb in cocaine‐induced psychomotor responses, we tested whether modulation of the LH or the LH‐LHb circuit affects cocaine‐induced locomotion. Cocaine‐induced locomotor activity and dopamine release were suppressed by the activation of the LH with 2‐[2,6‐difluoro‐4‐[[2‐[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide (PEPA), an AMPA receptor agonist. When the LH was inhibited by microinjection of a GABA receptor agonists mixture prior to cocaine injection, the cocaine's effects were enhanced. Furthermore, optogenetic activation of the LH‐LHb circuit attenuated the cocaine‐induced locomotion, while optogenetic inhibition of the LH‐LHb circuit increased it. In vivo extracellular recording found that the LH sent a glutamatergic projection to the LHb. These findings suggest that the LH glutamatergic projection to the LHb plays an active role in the modulation of cocaine‐induced psychomotor responses.
Moving house: How much choice do people with learning disabilities have about where they live?
Authors: Blood Lauren , Ribenfors Francesca , Hatton Chris , Marriott Anna 
Published: November 2023

AbstractBackgroundPeople with learning disabilities have the right to choose where they live. However, evidence suggests people's choices are limited due to a shortage of housing.Methods200 Lives was a mixed methods research project, which evaluated supported living and residential care for people with learning disabilities in England; 107 people with learning disabilities took part, 77 from supported living and 30 from residential care.FindingsTwo‐thirds of people in supported living compared to half of those in residential care chose the place they were currently living in; however, less than half of all participants looked at another property before moving to their current house. People in supported living were significantly more likely to have chosen who they lived with. Reasons for moving mainly consisted of reactive moves following an issue with the previous living situation. Many people had not considered moving in the future.ConclusionFindings suggest that people's choices about where to live were constrained regarding the properties on offer and who to live with. This suggests that people's housing rights were not being upheld. Support and housing providers should ensure that housing can adapt to people's changing needs and wishes over the course of their lives.
Featured Cover
Authors: Zhu Meng‐Chao , Hu Wei , Lin Lei , Yang Qing‐Wen , Zhang Lu , Xu Jia‐Lin , Xu Yi‐Tong , Liu Jia‐Sheng , Zhang Meng‐Di , Tong Xiao‐Yu , Zhu Kai‐Yi , Feng Ke , Feng Yi , Su Jian‐Zhong , Huang Xiu‐Feng , Li Jin 
Published: November 2023

The cover image is based on the Original Article Single‐cell RNA sequencing reveals new subtypes of lens superficial tissue in humans by Meng‐Chao Zhu et al., https://doi.org/10.1111/cpr.13477.
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Co‐designing a community lifestyle intervention program to reduce postpartum weight retention
Authors: Makama Maureen , Skouteris Helen , Moran Lisa J. , Hill Briony , Redman Leanne M. , Lim Siew 
Published: November 2023

AbstractBackgroundPostpartum weight retention is a major contributor to obesity in later life resulting in long‐term health consequences in women. Postpartum lifestyle interventions are known to be effective in reducing postpartum weight retention and improving the overall health and wellbeing of mothers but have poor reach and engagement. This study describes the engagement of mothers with young children in the development of a theory‐ and evidence‐based intervention to reduce postpartum weight retention.MethodsA participatory design methodology with input from a community mothers' group, literature reviews and an expert advisory group was applied. Mothers who were members of ‘Mothers of Preschoolers’ (MOPS) were invited to participate in a focus group discussion and two co‐design workshop sessions.ResultsThirteen women participated in a focus group discussion and 12 women in each co‐design workshop. We found that mothers valued having social support from their peers, practical support such as meal delivery, and learning opportunities that focus on the mother's health and wellbeing. The advisory group suggested leveraging the unique skills and prior experiences of mothers within the group and developing a curriculum that mothers can be trained to deliver.ConclusionA program that emphasizes the strengths and value of mothers can increase their self‐worth and self‐confidence resulting in intrinsic motivation to improve lifestyle behaviours. An intervention designed to be implemented by MOPS for its members and incorporated into their regular sessions has the potential for feasibility and acceptability among mothers with young children.Patient or Public ContributionMothers with young children were part of the program planners and were involved in the design and conduct of this study and in the interpretation of the findings. A member of a community mothers' group recruited other mothers with young children within the group to participate in a series of sessions to discuss their experiences of the postpartum period and preferences for a lifestyle program. The mothers identified the behavioural outcomes and program goals for a postpartum lifestyle program and then generated the program ideas based on these.
SPECTRORADIOMETRY AND COLORIMETRY IN THE LIGHTING INDUSTRY
Authors: JEROME CHARLES W. 
Published: November 2023

ABSTRACTSpectroradiometry is fundamental in the measurement and evaluation of color. It is used in the evaluation of new light sources, in the analysis of problem areas, and for the compilation of data for inclusion in the technical brochures describing lighting products. The basic elements of a spectroradiometer are described and the application of spectral‐power distribution measurements to photometry and colorimetry is illustrated.
ADDITIVE COLOR MIXTURE WITH FLUORESCENT PIGMENTS AND SPECIAL ILLUMINATION
Authors: STRAIN RICHARD A. 
Published: November 2023

ABSTRACTAlthough the artist uses subtractive color mixture when the starting point is a white surface and color mixture is accomplished by physically intermixing paints, he can use additive color mixture if he applies his paints to the canvas in small dots, creating a mosaic structure. Conventional pigments, however, lack a high enough relative brightness to synthesize white; the artist must revert to mixing white pigment to his paints to get a full range of lights and darks, just as in subtractive color mixture painting methods. By employing fluorescent pigments with special illumination, the visual artist can now obtain additive primaries of sufficient brightness to synthesize white; thus, for the first time, he can create images in his graphic media using purely additive color mixture.
Money and Credit Coexistence, Excess Capacity, and the Size of Monetary Aggregates
Authors: MENNUNI ALESSANDRO 
Published: November 2023

AbstractThis paper develops a model where money is demanded in excess of spending needs. As a result, money coexists with large availabilities of credit and the model explains the levels of monetary aggregates held in modern economies via the endogenous creation of inside money. At the heart of the model, there is a search friction in the goods market, which generates spare production and spending capacity. As a consequence, there is an endogenous productivity wedge, due to spare production capacity, and an endogenous money velocity, due to spare spending capacity.