bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear Nitrogen‐Doped Carbon‐Based All‐Optical Switch and Wavelength Converter in Mid‐Infrared Region
Authors: Wang Ke , Xie Zhoufa , Ji Jianhua , Huang Haiming , Song Yufeng , Wang Zhenhong , Zhang Bin 
Published: January 2025

AbstractExploring all‐optical devices built upon new nanomaterials and moving toward all optical signal processing has been attracted ever‐growing interest. Nitrogen‐doped carbon shows tremendous application potential in nonlinear optics due to its excellent and stable optoelectronic characteristics. Due to the reduction in scattering intensity as increasing optical wavelength, the midinfrared 2 µm band is less affected by atmospheric scattering. This study presents an experimental demonstration of a 2 µm optical Kerr switch on a microfiber, designed using nonlinear nitrogen‐doped carbon nanospheres (NCN), and combined with a highly nonlinear fiber (HNLF) to achieve cascaded four‐wave mixing (FWM) phenomena. Experimental results show that the Kerr switch exhibits an extinction ratio of approximately 12.5 dB under appropriate pump light application, indicating effective signal light control. Moreover, the maximum conversion efficiency of the first‐order cascaded FWM reaches −20.08 dB, and the second‐order efficiency reaches −39.3 dB, with a maximum wavelength spacing of 18 nm. This represents the first investigation of optical Kerr switching and cascaded FWM in the 2 µm wavelength range. This study provides new insights and approaches for developing optical signal processing technology and lays the foundation for future high‐performance photonic devices in this wavelength range.
Discovering a Novel Cyan‐Light‐Emitting Thiosilicate Phosphor, Li2BaSiS4:Eu2+, via Experimental Active Learning
Authors: Cho Min Young , Asaithambi Sankaiya , Kim Heejeong , Lee Byung Do , Park Woon Bae , Sohn Kee‐Sun 
Published: January 2025

AbstractThere are likely numerous known and yet‐to‐be‐discovered alkaline earth (AE)‐alkali metal (A) thiosilicates, thioaluminates, and thiophosphates that can serve as suitable hosts for the Eu2+ 5d‐4f emission. These structures offer an infinite number of possible compositions, with the potential for multi‐elemental occupancy at the AE and A sites. Screening such an extensive exploratory space through conventional experimentation poses a significant challenge due to the so‐called combinatorial explosion issue. To address this challenge, an artificial intelligence, more specifically a particle swarm optimization (PSO) algorithm within an experimental active learning framework, that enables to explore the effectively infinite search space and ultimately identify a novel, promising host structure candidate for Eu2⁺ 5d‐4f emission is employed. Starting with completely random compositions and no preset structures in the vast exploratory space, the PSO‐driven experimental active learning process converges on a single‐phase Li2BaSiS4:Eu2+ phosphor, featuring a tetragonal structure with I‐42 m symmetry (a = 6.5825 Å, c = 8.0015 Å). The Li2BaSiS4:Eu2+ phosphor exhibits cyan‐blue light emission with a peak at 480 nm, a full width at half maximum of 35 nm (1423 cm−1), and a broad excitation range from 325 to 425 nm, indicating its potential for application in light‐emitting diodes (LEDs).
Osteopenic occult vertebral fracture is associated with poor oncological outcome in patients with hepatocellular carcinoma after hepatic resection
Authors: Haruki Koichiro , Furukawa Kenei , Akaoka Munetoshi , Tsunematsu Masashi , Matsumoto Michinori , Taniai Tomohiko , Shirai Yoshihiro , Onda Shinji , Hamura Ryoga , Ikegami Toru 
Published: January 2025

AbstractBackgroundAlthough osteopenia has been associated with poor outcomes in patients with hepatocellular carcinoma (HCC), the oncological impact of occult vertebral fracture (OVF) has not been investigated.MethodsThe study comprised 235 patients who had undergone primary hepatic resection for hepatocellular carcinoma between 2008 and 2019. Osteopenia was evaluated with computed tomographic measurement of pixel density in the midvertebral core of the 11th thoracic vertebra. OVF was defined if the ratios of central/anterior or central/posterior heights of the vertebrae, measured using sagittal computed tomography reconstruction between 11th thoracic vertebra to 5th lumber vertebrae, <0.8. Multivariate Cox proportional hazard models were conducted to assess disease‐free and overall survival adjusting for potential confounders.ResultsOccult vertebral fracture was identified in 93 patients (40%), while osteopenia in 65 patients (28%). Osteopenic OVF was identified in 27 patients (12%). In multivariate analysis, gender (p < 0.001), serum PIVKA‐II level ≥ 200 mAU/ml (p = 0.005), C‐reactive protein‐to‐albumin ratio ≥0.04 (p = 0.03), multiple tumors (p < 0.001), type of resection (p < 0.001), low skeletal muscle index (p = 0.002), and osteopenic OVF (HR 3.07, 95% CI 1.78–5.28, p < 0.001) were independent and significant predictors of cancer recurrence, while gender (p = 0.002), Child–Pugh grade B (p = 0.009), C‐reactive protein‐to‐albumin ratio ≥0.04 (p = 0.03), multiple tumors (p = 0.005), low skeletal muscle index (p < 0.001), and osteopenic OVF (HR 4.75, 95% CI 2.41–9.39, p < 0.001) were independent predictors of overall survival.ConclusionsOsteopenic OVF is associated with poor oncological outcomes in patients with hepatocellular carcinoma after hepatic resection. Our findings provide a compelling rationale for the further investigation of the interplay between tumor and bone metabolism.
3D‐printed pillar array pore ceramic membrane for high areal capacity zinc‐based flow battery
Authors: Liu Xin , Xu Kenan , Ding Jingyi , Chen Ting , Hou Xiaoxuan , Cao Hongyan , Xia Yu , Lu Yuqin , Wang Yixing , Fan Su , Huang Kang , Xu Zhi 
Published: January 2025

AbstractZinc‐based flow batteries (ZFBs) are promising for large‐scale energy storage applications. However, the formation of Zn dendrites and the limited areal capacity of ZFBs hinder their further development. In this study, we designed a digital light‐processed 3D‐printed pillar array pore ceramic membrane (3DPC) to construct ZFBs with high areal capacity and long cycle life. The pillar array pore design reduces the transmembrane resistance by ~60% and facilitates K+ and Na+ transport. The pore arrays serve as electrolyte reservoirs to regulate interfacial ion distribution and provide sufficient space for Zn deposition. Moreover, the surface hardness of the ceramics up to 1.46 GPa provides resistance against zinc dendrite damage. Furthermore, the cell based on the designed 3DPC exhibits a stable energy efficiency exceeding 79% during operation for over 950 h at an areal capacity of 280 mAh cm−2. This study demonstrates the promising potential of 3D‐printed ceramic membranes for metal‐based flow batteries.
Cardiac Involvement and TBCK‐Related Neurodevelopmental Disorder: Is It a New Feature of This Condition?
Authors: Mastromoro Gioia , Guadagnolo Daniele , Gianno Francesca , Khaleghi Hashemian Nader , Terracciano Alessandra , Bernardini Laura , Giancotti Antonella , Novelli Antonio , Piacentini Gerardo , Di Gioia Cira , Pizzuti Antonio 
Published: January 2025

ABSTRACTTBCK (TBC1 Domain‐Containing Kinase) encodes a protein playing a role in actin organization and cell growth/proliferation via the mTOR signaling pathway. Deleterious biallelic TBCK variants cause Hypotonia, infantile, with psychomotor retardation and characteristic facies 3. We report on three affected sibs, also displaying cardiac malformations. The parents, a consanguineous couple of first cousins, were referred to schedule invasive diagnosis for their sixth pregnancy. They were known to carry the pathogenic c.1532G>A TBCK variant. The variant was originally identified in homozygosity in the first and second children of the couple, both affected. One also presented a right‐sided aortic arch. The other had Tetralogy of Fallot. Present pregnancy ultrasound revealed cystic hygroma and hypoplastic nasal bone, not previously reported in this condition. Chromosomal microarray analysis found no imbalance and identified 8.6% runs of homozygosity. Whole exome sequencing confirmed the TBCK variant without additional pathogenic or candidate variants. Fetal echocardiography revealed left ventricle and aortic arch hypoplasia. The couple opted for pregnancy termination. Fetopsy confirmed sonographic findings and revealed a hypoplastic aorta arising from right ventricle and corpus callosum agenesis. Interestingly, the cardiac phenotype segregates with variants and cardiac involvement might be considered a new feature of this variant causing Hypotonia, infantile, with psychomotor retardation and characteristic facies 3.
Lanthanide‐Controlled Protein Switches: Development and In Vitro and In Vivo Applications
Authors: Guo Zhong , Smutok Oleh , Ronacher Chantal , Aguiar Rocha Raquel , Walden Patricia , Mureev Sergey , Cui Zhenling , Katz Evgeny , Scott Colin , Alexandrov Kirill 
Published: January 2025

AbstractLanthanides, which are part of the rare earth elements group have numerous applications in electronics, medicine and energy storage. However, our ability to extract them is not meeting the rapidly increasing demand. The discovery of the bacterial periplasmic lanthanide‐binding protein lanmodulin spurred significant interest in developing biotechnological routes for lanthanide detection and extraction. Here we report the construction of β‐lactamase‐lanmodulin chimeras that function as lanthanide‐controlled enzymatic switches. Optimized switches demonstrated dynamic ranges approaching 3000‐fold and could accurately quantify lanthanide ions in simple colorimetric or electrochemical assays. E.coli cells expressing such chimeras grow on β‐lactam antibiotics only in the presence of lanthanide ions. The developed lanthanide‐controlled protein switches represent a novel platform for engineering metal‐binding proteins for biosensing and microbial engineering.
Porous 3 d‐4 f Coordination Clusters for Selective Visible‐Light Photocatalytic CO2 Reduction to CO
Authors: Chen Wei‐Peng , Bai Kai‐Peng , Lv Man‐Ting , Ni Shuang , Huang Chang , Yang Qing‐Yuan , Zheng Yan‐Zhen 
Published: January 2025

AbstractWe report herein two families of porous coordination clusters (PCCs) with 216 nuclearity (M120RE96 or PCC‐216MR) and 300 nuclearity (Co144Gd156 or PCC‐300CG). For the first family M could be either nickel or cobalt, and RE = Pr, Nd, Sm, Eu, and Gd; while the latter features the highest nuclearity of transition‐rare earth metal clusters. Characterized by their cube‐like, hollow structures, these clusters exhibit the ability to absorb N2 and CO2. Besides, these clusters can be dissolved in both aqueous and acetonitrile/methanol solutions, and capable of acting as homogeneous catalysts for converting CO2 to CO under visible light. The gadolinium analogues of these clusters all show turnover numbers over 10000 and turnover frequencies over 1 s−1. In particular, the nickel based bimetallic cluster (PCC‐216NG) demonstrates nearly 100 % selectivity for the reduction product, which may open a new direction for the design and development of PCCs based catalysts.
Investigation on the Regulation Mechanisms of Viscosity–Temperature Characteristics of High Calcium–Iron Coal by Coal Blending
Authors: Liu Xuefei , Li Fenghai , Ma Mingjie , Wang Yong , Yang Ziqiang , Fang Yitian 
Published: January 2025

ABSTRACTEntrained‐flow bed gasification was an important way to realize clean coal conversion. However, the high calcium–iron coal ash had a low flow temperature, low viscosity, and strong fluctuations in viscosity, which severely affected the service life of the gasifier. It was necessary to regulate its ash fusion temperature and viscosity–temperature characteristics (AFV). In the paper, the AFV of Datong coal (DTC, a high calcium–iron coal) and its regulation mechanism were investigated by ash fusion temperature tester, high‐temperature viscometer, Raman spectrometer, differential scanning calorimetry, X‐ray diffractometer, FactSage software, and activation energy calculation. With the increasing Pingdingshan coal (PDS, a high silicon–aluminum coal) mass ratio, the AFV of DTC mixtures increased, and the viscosity fluctuation of DTC mixtures disappeared gradually. When PDS mass ratio is in the range of 18%–24%, the flow temperature and viscosity of DTC ash were 1375°C–1400°C and 18–22 Pa·s, respectively. The increasing PDS mass ratio, the formation of high melting point anorthite and its increasing content, the polymerization degree of DTC mixed ash increasing, and a gradual increase in activation energy as well as their corresponding crystallization behavior led to the increase in the AFV. The mineral transformations and the position variation in the ternary phase diagram of ash compositions with PDS addition by FactSage calculation also explained the variations in the viscosity–temperature characteristics.
Bioactive Functionalized Chitosan Thermo‐Responsive Hydrogels as Promising Platforms for Therapeutic, Regenerative Oral, and Maxillofacial Applications
Authors: Alkandari Meshari , Barai Paritosh , Atia Gamal Abdel Nasser , Mohamed Sara Z. , Ghobashy Mohamed Mohamady , Shalaby Hany K. , Foda Tarek , Rabbee Muhammad Fazle , Mallick Samir , Barai Hasi Rani , Hossain Mohammad Nazir 
Published: January 2025

ABSTRACTDue to their superior physicochemical features, chitosan thermosensitive hydrogels are multipurpose platforms that are frequently used in the biomedical industry. Many investigations have been conducted recently to modify their pore dimensions, expansion, biodegradability, stimulus‐reaction characteristics, and other characteristics in order to better tailor them to the complex craniofacial tissues. They have been the focus of various studies that have attempted to load biological cargos for therapeutic and regenerative uses in the oro‐facial tissues. This article assesses the utility and advancements of chitosan thermosensitive hydrogel‐based pharmaceutical delivery devices for the management of craniofacial disorders such as dental caries, endodontic diseases, periodontitis, temporomandibular disorders, mucosal diseases, cancer, and so forth.
Does It Pay Off to Disclose Sustainability Information? The Effect of ESG Disclosure on ESG Controversies in European Banks
Authors: Carè Rosella , Agnese Paolo , Cerciello Massimiliano , Taddeo Simone 
Published: January 2025

ABSTRACTThis paper empirically investigates the relationship between specific dimensions of ESG disclosure and ESG controversies. We analyze an unbalanced panel sample of European banks between 2015 and 2022, implementing the GMM‐SYS version of the Arellano‐Bond estimator for dynamic panels. The study results indicate that banks disclosing full information are more likely to face scandals. In addition, EU membership has a positive impact on the ESG controversies. Overall, our research suggests that while transparency is intended to enhance accountability, it may also lead to heightened scrutiny and the exposure of more controversies. Our study, therefore, sheds new light on current knowledge on ESG disclosure and controversies, integrating theoretical, practical, policy, and investor perspectives.
Cuproplasia and cuproptosis, two sides of the coin
Authors: Lu Kaizhong , Wijaya Chandra Sugiarto , Yao Qinghua , Jin Hongchuan , Feng Lifeng 
Published: January 2025

AbstractCopper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory network, defined as cuproplasia. Thus, targeting copper chelation to reduce copper levels has been considered a rational tumor therapy strategy. However, overloaded copper ions could be toxic, which leads to the aggregation of lipoylated mitochondrial proteins and the depletion of iron‐sulfur clusters, ultimately resulting in cell death, termed cuproptosis. Upon its discovery, cuproptosis has attracted great interest from oncologists, and targeting cuproptosis by copper ionophores exhibits as a potential anti‐tumor therapy. In this review, we present the underlying mechanisms involved in cuproplasia and cuproptosis. Additionally, we sum up the chemicals targeting either cuproplasia or cuproptosis for cancer therapy. Further attention should be paid to distinguishing cancer patients who are suitable for targeting cuproplasia or cuproptosis.
Patterns of Treatment and Real‐World Outcomes of Patients With Non‐small Cell Lung Cancer With EGFR Exon 20 Insertion Mutations Receiving Mobocertinib: The EXTRACT Study
Authors: Liu Geoffrey , Nyaw Shi Feng , Mok Tony S. K. , Curcio Hubert , Cortot Alexis B. , Kam Tsz Yeung , Descourt Renaud , Chik Yin Kwan , Cheema Parneet , Gwinnutt James M. , Churchill Eric N. , Nyborn Justin , Curran Eileen , Savell Alexandra , Yin Yu , Chong Katie , Tanaka‐Chambers Yuka , Kretz Julian , Cadranel Jacques 
Published: January 2025

ABSTRACTBackgroundReal‐world data regarding patients with non‐small cell lung cancer (NSCLC) with EGFR exon 20 insertion (ex20ins) mutations receiving mobocertinib are limited. This study describes these patients' characteristics and outcomes.MethodsA chart review was conducted across three countries (Canada, France, and Hong Kong), abstracting data from eligible patients (NCT05207423). The inclusion criteria were: ≥ 18 years old; diagnosis of stage IIIB‐IV NSCLC with EGFR ex20ins between January 1, 2017 and November 30, 2021; received mobocertinib. Data on demographics, clinical parameters, treatment patterns, mobocertinib exposure, real‐world outcomes, and adverse events (AEs) were collected. Results are also reported by Asian/Non‐Asian races.ResultsOverall, 105 patients were enrolled (median [IQR] age at initial diagnosis: 64.0 years [56, 71]; women: 62.9%). The most common first‐line of therapy (LoT) was chemotherapy; the most common second LoT was EGFR tyrosine kinase inhibitors. Most patients received mobocertinib during LoT two and three (74.3%); the maximum dose was 160 mg/day for 67.6% of the cohort (mean [SD] daily dose: 130.6 mg [36.68]). The median real‐world progression‐free survival (PFS) on mobocertinib was 4.76 months (95% CI: 3.98, 6.21). The overall response rate and disease control rate were 20.0% and 48.6%, respectively (median duration of response: 8.34 months [95% CI: 3.61, 9.49]). The median overall survival (OS) was 26.28 months (95% CI: 20.21, 36.44). Asian patients had numerically superior PFS and OS compared with non‐Asian patients. Regarding safety analysis, 73 patients (69.5%) experienced any AE. The most common AE was diarrhea (any grade) (52 patients; 49.5%).ConclusionsThese data illustrate the real‐world effectiveness of mobocertinib.
Characterization of Hospital Admissions During Immune Checkpoint Inhibitor Therapy: Insights From the ICOG Study
Authors: Wiegmann Jonas Paul , Fröhlich Tabea , Möhn Nora , Duzzi Laura , Narten Emily , Aurich Johanna , Thomas Janin , Grote‐Levi Lea , Mahjoub Susann , Berliner Dominik , Wirth Thomas , Golpon Heiko , Bollmann Benjamin‐Alexander , Von Wasilewski Imke , Gutzmer Ralf , Heidel Florian H. , Skripuletz Thomas , Beutel Gernot , Ivanyi Philipp ,   ICOG‐CCCH (Immune Cooperative Oncology Group, Comprehensive Cancer Center Hannover)
Published: January 2025

ABSTRACTIntroductionImmune checkpoint inhibitors (ICI) have improved the therapeutic arsenal in outpatient oncology care; however, data on necessity of hospitalizations associated with immune‐related adverse events (irAEs) are scarce. Here, we characterized hospitalizations of patients undergoing ICI, from the prospective cohort study of the immune cooperative oncology group (ICOG) Hannover.MethodsBetween 12/2019 and 06/2022, 237 patients were included. Clinical data and characteristics of ICI were collected during a 6‐month observation period after the initiation of therapy. Descriptive statistics and Kaplan–Meier statistics were administered.ResultsDuring the observation period, 30/237 patients were hospitalized (HA(+)). Most common underlying tumor entities were malignant melanoma (59.5%), renal cell carcinoma (13.1%), and nonsmall‐cell lung carcinoma (12.7%). HA(+) patients exhibited an increased rate of pulmonary and cerebral metastases. We observed a significantly higher hospitalization rate during dual ICI with Nivolumab and Ipilimumab (p = 0.001). The predominant irAEs for hospitalization were colitis (26.7%), followed by hypophysitis (13.3%), leading to a median hospitalization of 7 (1–34) days. Interdisciplinary consultations were frequent, especially to gastroenterology (46.7%) and neurology (26.7%). Although a trend toward a prolonged overall survival in the HA(+) subgroup was identified, no statistically significant differences were found.DiscussionThe hospitalization rate of 12.6% is comparable to rates reported in previous studies. There was a disproportionate admission of patients with immune‐related colitis and hypophysitis compared to the prevalence described under ICI. We observed a high need for interdisciplinary consultations in line with the heterogeneity of immune‐mediated side effects. Compared to non‐hospitalized patients, there was no survival disadvantage in the HA(+) cohort.ConclusionWith a relatively low hospitalization rate, short length of stay, and good clinical outcome, our data support the outpatient nature of ICI. The findings underscore the importance of interdisciplinary collaboration and vigilant monitoring of irAEs to ensure timely recognition and management.
Design, Synthesis, and In Silico Molecular Docking Studies of Adamantanyl Hydrazinylthiazoles as Potential Antidiabetic Agents
Authors: Choudhry Sabah Siddique , Mehmood Hasnain , Akhtar Tashfeen , Haroon Muhammad , Musa Mustapha , Sajid Zaroon 
Published: January 2025

ABSTRACTDiabetes mellitus (DM) is a widespread disease that poses a major threat to millions of people. To address this issue, we have synthesized seventeen new 4‐(adamantan‐1‐yl)‐(2‐(arylidene)hydrazinyl)thiazoles (3a–q) via Hantzsch synthetic approach. The molecular structures of all the compounds were confirmed using FT‐IR, 1H‐ and 13C‐NMR spectroscopy, and HR‐mass spectrometry. Protein kinase, α‐amylase, glycation, and oxidation inhibition potential of all compounds were also investigated, and it was found that compounds 3b, 3c, 3e–3g, and 3i–3q have shown excellent α‐amylase inhibition (IC50 = 7.91 ± 0.07 to 28.57 ± 0.1 µM), compounds 3c, 3e, 3i, 3k, and 3p (IC50 = 30.6 ± 0.06 to 37.8 ± 0.005 ppm) were found to be highly potent anti‐glycating agents, and compounds 3c, 3g, 3h, 3k, and 3m were found to be more potent protein kinase inhibitors as compared to standards. The compounds 3b, 3c, 3d, 3e, 3f, 3g, 3i, 3k, 3l, 3m, 3n, 3p, and 3q have shown good antioxidant potential (IC50 = 27.5 ± 0.09 to 48.8 ± 0.09 µM) as compared to standard ascorbic acid (IC50 = 51.3 ± 0.1 µM). The biocompatibility of all samples was also tested by employing brine shrimp lethality and in vitro hemolytic assays and was found to be safe to human erythrocytes at tested concentrations. Furthermore, the molecular docking simulation study also revealed that almost all synthesized compounds have potential interactions with target proteins at the molecular level.