The efficacy of Mercurius solubilis, an homeopathic medication, for the treatment of periodontal disease
Authors: Monterde‐Coronel María Elena , Asbun‐Bojalil Juan , Hernández‐Campos María Elena , Lopez‐Sánchez Pedro , Aguilar‐Faisal Jose Leopoldo 
Published: November 2023

BackgroundPeriodontal disease, is a public health problem affecting 60–90% of the world adult population. The destructive stage is characterized by gingival inflammation, clinical attachment loss, and the formation of periodontal pockets between the gums and teeth. Gram‐negative bacteria can produce chronic infections by attaching themselves and growing on the surface of periodontal tissue. They respond poorly to antibiotic treatment and cannot be prevented by immunization.1,2,3,4,5 Research has provided insights into metabolic elements of the host that are implicated in this disease.Homeopathy utilizes small doses of diverse substances to stimulate the processes of the body to cure and regulate itself.7 It is a medical approach based on the Law of Similarity.8 If a substance produces a series of signs and symptoms in a healthy individual, it is capable of curing similar symptoms in a patient. For periodontal disease, Mercurius solubilis Hg2 (NO3)2) was selected.ObjectiveTo evaluate the effect of Mercurius solubilis 12c administered orally during the treatment of patients with periodontitis, based on quantification of the matrix metalloproteinases (MMPs) in saliva by the immunoblot technique.Materials and MethodsThis was a random, double‐blind clinical trial with two modes of treatment: Mercurius solubilis and placebo. Inclusion criteria were relapse of periodontal disease and the signing of informed consent. A health questionnaire was applied to each participant, as well as a clinical exploration using standards established by the World Workshop on Clinical Periodontology. Each patient was instructed on the proper techniques for brushing his/her teeth and controlling plaque, as well as the use of hygiene aids.13,14 Saliva was obtained (unstimulated) and stored at −70 °C. The quantification of total proteins in saliva was carried out by the Lowry method, and the separation of proteins by electrophoresis (SDS Page), with the specificity of immunochemical recognition of MMPs and control of the charge of β actin. Quantity (Version 4.1, Biorad) software was used for statistical analysis, applying two‐way ANOVA (p<0.05).ResultsPatients completely adhered to the combined treatment. No adverse effects have been reported during treatment with Mercurius solubilis. The diagnostic probe and posterior reassessment was carried out by a blinded professional. A decrease was found in the depth of the periodontal pockets of both treatment groups. MMP‐8 expression decreased in both groups after 3‐week treatments. No differences between groups have been identified in the interim analysis.DiscussionThe treatment of periodontal disease requires the combination of dental, surgical and pharmacological procedures. The selection of beta‐lactam antibiotics to treat this condition is based on epidemiological criteria in function of the clinical assessment. These antibiotics are only effective against some Gram‐negative bacteria and produce a high proportion of adverse effects. The use of alternative therapy, such as homeopathy, allows the doctor to consider mental and physical aspects of the disease, thus contributing to the total recovery of oral hygiene.Conclusionand patients have made note of the benefits of the easy administration and innocuousness. Additionally, this homeopathic therapy for patients with periodontal disease is safe and effective.Support or Funding InformationClinical study founded by special grants of Escuela Superior de Medicina del Instituto Politécnico Nacional