bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Edukasi Konseling Berbasis Teori Health Belief Model Terhadap Pengetahuan Pencegahan Komplikasi Hipertensi di Semarang
Authors: Talango Farid , Kusdhiarningsih Betty 
Published: January 2024

Latar Belakang: Hipertensi merupakan tekanan darah persisten dimana tekanan sistoliknya ≥ 140 mmHg dan tekanan diastolik ≥90 mmHg. Hipertensi tergolong penyakit kronis yang dapat meningkatkan risiko terjadinya komplikasi seperti stroke, penyakit jantung koroner dan gagal ginjal, sehingga perlu dilakukan pengkajian kemampuan pengetahuan pencegahan komplikasi hipertensi. Tujuan: Untuk menganalisis Pengaruh edukasi konseling dan pembinaan kesehatan berbasis teori Health Belief Model terhadap pengetahuan pencegahan komplikasi hipertensi di Semarang. Metode: Penelitian ini menggunakan pre test dan post test design pada kelompok perlakuan dan kelompok kontrol. Pengambilan sampel menggunakan metode purposive sampling dengan kriteria pasien menderita hipertensi berusia > 46 tahun yang berobat di Puskesmas Kedung Mundu Semarang. Jumlah sampel masing-masing kelompok sebanyak 48 responden. Responden diberikan sebanyak 20 pertanyaan untuk mengukur pengetahuan pencegahan komplikasi hipertensi. Analisis data menggunakan Mann Whitney. Hasil: Hasil penelitian membuktikan bahwa karakteristik responden paling banyak berusia usia lansia akhir 43 responden (44,8%), berjenis kelamin laki-laki 53 responden (55,2%), berpendidikan SMA sederajat 39 repsonden (40,6%), bekerja sebagai swasta 55 responden (57,3%), dan menderita hipertensi antara 1 tahun sampai 5 tahun 63 repsonden (65,6%). Tingkat pengetahuan pencegahan komplikasi hipertensi pada kelompok perlakuan lebih tinggi sebesar 37,40 (Baik) dibandingkan dengan kelompok kontrol sebesar 31,77 (Baik). Terdapat perbedaan signifikan pada kelompok perlakuan pre test dan post test dengan nilai P-Value sebesar 0,000 < 0,05. Hasil penelitian membuktikan bahwa terdapat perbedaan yang signifikan pada kelompok kontrol pre test dan post test dengan nilai P-Value sebesar 0,000 < 0,05. Hasil penelitian terbukti bahwa terdapat perbedaan pengetahuan antara kelompok perlakuan dan kelompok kontrol dengan nilai P-Value sebesar 0,000 < 0,05. Kesimpulan: Edukasi konseling berbasis teori Health Belief Model dinilai efektif dalam meningkatkan pengetahuan pencegahan komplikasi hipertensi.
The Role of Youth in Management of BUMdes in Kedai Durian Village, Delitua District
Authors: Mutia  
Published: January 2024

This research took place in Kedai Durian Village, Delitua District, Deliserdang Regency. This location was chosen based on the researcher's investigation that the BUMDes in the village were managed and run by youths whose the institution they are incorporated in Karang Taruna Citra Yodha. The business that taken by the youth of the Kedai Durian village or Karang Taruna Citra Yodha is the renting (rental), where BUMDes Kedai Durian is a business to rent tents / tratak for party. The reason this business was chosen because it was adjusted to the pontential of the region where the Kedai Durian village has a dense population. The Kedai Durian village which borders the area of ​​Medan City, indirectly also affects the condition of the village which has moved into a densely populated community. Because of the population density in Kedai Durian Village, of course has a potential to develop the rental business, where people will use a lot of these rental services.
THE ROLE OF YOUTH IN THE MARKETING OF PONOT WATER TOURISM FOR REGIONAL DEVELOPMENT IN ASAHAN DISTRICT
Authors: JEDS  , Anazmi Feby 
Published: January 2024

The purpose of this study is to look at the role of youth in Asahan Regency in marketing Ponot Waterfall Tourism. This research focuses on the role that has been carried out by young people in Asahan Regency in marketing Ponot Waterfall Tourism to become a leading tourist in Asahan Regency.
Asahan Regency is one of the regencies in North Sumatra Province which is famous for its tourist attractions. One of them is the natural tourism area of ​​Ponot Waterfall, located in Aek Songsongan sub-district, Asahan Regency. The development of the Ponot Waterfall Tourism Area is inseparable from the role of Asahan Regency youth who consistently and innovatively market the Ponot Waterfall Tourism area to become one of the leading tourist destinations in Asahan Regency. The method used in this research is descriptive method with a qualitative approach. This study took primary data through informants and secondary data from relevant agencies, namely the Asahan Regency Sports and Tourism Youth Service, Asahan KNPI, the Regency Statistics Agency.
The results of the study indicate that the role of Asahan Regency youth in marketing Ponot Waterfall tourism for regional development is that youth play a role as social control, moral strength and agents of change .
Phytochemical Profiles, in vitro Antioxidants, and Anti-inflammatory Activities of Flowers and Leaves of Lantana camara L. Grown in South of Tunisia
Authors: Ben Othman Khadija , Maaloul Najeh , Nhidi Sana , Cherif Mohamed Majdi , Idoudi Sourour , Elfalleh Walid 
Published: January 2024

The current study assesses the photochemical profiles, the in vitro antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), reducing power ferric and silver nanoparticule) and anti-inflammatory activity of Lantana camara L. leaves and flowers collected from the South of Tunisia. Bioactive extracts of two organs were prepared through an ultrasound-assisted extraction in ethanol. Herein, multivariate statistical analysis was performed to define the relationship between biological activities and the bioactive molecules content and composition. Phytochemical profiling showed higher phenolic and flavonoids contents in leaves extracts than in those obtained from flowers, while the condensed tannins was absent in both organs. LC-MS analysis identified 16 and 15 phenolic compounds from flowers and leaves extracts, respectively. The flowers extract was especially rich in Kaempferol, luteolin-7-O-glucoside, quinic acid and apigenin-7-O-glucoside. Kaempferol, luteolin-7-O-glucoside, quinic acid and syringic acid were identified as the prevalent compounds in leaves extract. The latter exhibited the highest DPPH and ABTS radical scavenging potentials. Whereas flowers extracts revealed the highest reducing potential of ferric and silver ions. However, the leaves and flowers extracts are unable to protect bovine serum albumin (BSA) from thermal denaturation. Furthermore, significant correlations (p < 0.05) were recorded between phytochemical profile and biological activities, as well as between different antioxidant studied assays. The obtained results present practical data for the potential application of L. camara as a sustainable source of multi-functional molecules in food and medicinal industries.
Exogenous Application of Potassium and Zinc for the Growth, Yield and Agronomic Zinc Biofortification of Wheat (Triticum aestivum L.)
Authors: Murtaza Ghulam , Shah Muhammad Nadeem , Saif Muhammad Talha , Shaheryar Muhammad , Ain Qurat Ul , Yaseen Muhammad Atif , Hayat Hafiz Saqib , Hussain Shabir , Aziz Aamir , Hayat Momna , Altaf Muhammad Tanveer , Rasool Muhammad Wajahat , Abbas Muneera , Shahbaz Muhammad 
Published: January 2024

In agriculture, the application of micronutrient application takes place through soil application, foliar spraying, or added seed treatments. Potassium (K) application fulfills the deficiency of K in soil due to a continuous exhaustive cropping system. Zinc (Zn) bio-fortification of seed by priming is responsible for increasing the concentration of Zn in the edible part of a seed with the aim of remedying malnutrition. For this, a field experiment was conducted at the Agronomic research area, Bahauddin Zakariya University, Multan. Treatment included different rates of K (0, 40, 60, and 80 kg ha-1) and different rates of Zn (0, 0.2, 0.4, and 0.6%). Potassium was applied in fertigation while zinc was applied in foliar form. The experiment was designed in Randomized complete block design (RCBD) and was repeated three times. It resulted that different rate of potassium and zinc application showed a significant effect on plant growth and yield attributes. Plant growth and yield increased with increasing the rate of potassium and zinc application and decreased with the decreasing the rate of application of potassium and zinc application. The maximum values for plant growth and yield attributes were observed with K3 and Zn3 while the minimum values were recorded with the application of K0 and Zn0. Results regarding the nutrient uptakes showed that maximum values for zinc uptake were also recorded in seed and stem attributes. Maximum values for zinc uptake in seed and stem (37.2 and 14.5 mg/kg) were observed in the Zn3 treatment and the minimum values for zinc uptake (30.1 and 11 mg/kg) were recorded Zn0 treatment, respectively. It was concluded that 80 kg ha-1 application of potassium with 0.6 % foliar application of zinc significantly affects the growth and yield of wheat crops. Zinc foliar application can be helpful for zinc fortification.
Intrinsic signal optoretinography of dark adaptation abnormality due to rod photoreceptor degeneration
Authors: Ding Jie , Kim Tae-Hoon , Ma Guangying , Yao Xincheng 
Published: January 2024

This research aims to investigate the potential of using intrinsic optical signal (IOS) optoretinography (ORG) to objectively detect dark adaptation (DA) abnormalities related to rod photoreceptor degeneration. Functional optical coherence tomography (OCT) was employed in both wild-type (WT) and retinal degeneration 10 (rd10) mice to conduct this assessment. Dynamic OCT measurements captured the changes in retinal thickness and reflectance from light-to-dark transition. Comparative analysis revealed significant IOS alterations within the outer retina. Specifically, a reduction in thickness from external limiting membrane (ELM) peak to retinal pigment epithelium (RPE) peak was observed (WT: 1.13 ± 0.69 µm, 30 min DA; rd10: 2.64 ± 0.86 µm, 30 min DA), as well as a decrease in the intensity of the inner segment ellipsoid zone (EZ) in 30 min DA compared to light adaptation (LA). The reduction of relative EZ intensity was notable in rd10 after 5 min DA and in WT after 15 min DA, with a distinguishable difference between rd10 and WT after 10 min DA. Furthermore, our findings indicated a significant decrease in the relative intensity of the hypo-reflective band between EZ and RPE in rd10 retinas during DA, which primarily corresponds to the outer segment (OS) region. In conclusion, the observed DA-IOS abnormalities, including changes in ELM-RPE thickness, EZ, and OS intensity, hold promise as differentiators between WT and rd10 mice before noticeable morphological abnormalities occur. These findings suggest the potential of this non-invasive imaging technique for the early detection of dysfunction in retinal photoreceptors.
Cross-talk between Helicobacter pylori and gastric cancer: a scientometric analysis
Authors: Yang Shanshan , Hao Shaodong , Ye Hui , Zhang Xuezhi 
Published: January 2024

BackgroundHelicobacter pylori (HP) is considered a leading risk factor for gastric cancer (GC). The aim of this article is to conduct bibliometric and visual analysis to assess scientific output, identify highly cited papers, summarize current knowledge, and explore recent hotspots and trends in HP/GC research.MethodsA bibliographic search was conducted on October 24, 2023, to retrieve relevant studies on HP/GC research between 2003 and 2022. The search terms were attached to HP and GC. The main data were from the Web of Science Core Collection (WoSCC). Data visualization was performed using Biblioshiny, VOSviewer, and Microsoft Excel.ResultsIn HP/GC research, 1970 papers were retrieved. The total number of papers (Np) in HP/GC was growing from 2003 to 2022. China and Japan were in the leading position and made the most contributions to HP/GC. Vanderbilt University and the US Department of Veterans Affairs had the highest Np. The most productive authors were Peek Jr Richard M. and Piazuelo M Blanca. Helicobacter received the most Np, while Gastroenterology had the most total citations (TC). High-cited publications and keyword clustering were used to identify the current status and trends in HP/GC research, while historical citation analysis provided insight into the evolution of HP/GC research. The hot topics included the effect of HP on gastric tumorigenesis and progression, the pathogenesis of HP-induced GC (HP factors), and the mechanisms by which HP affects GC (host factors). Research in the coming years could focus on topics such as autophagy, gut microbiota, immunotherapy, exosomes, epithelial-mesenchymal transition (EMT), and gamma-glutamyl transpeptidase (GGT).ConclusionThis study evaluated the global scientific output in HP/GC research and its quantitative characteristics, identified the essential works, and collected information on the current status, main focuses and emerging trends in HP/GC research to provide academics with guidance for future paths.
Combining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration
Authors: McGinnis Kathleen A. , Justice Amy C. , Marconi Vincent C. , Rodriguez-Barradas Maria C. , Hauser Ronald G. , Oursler Krisann K. , Brown Sheldon T. , Bryant Kendall J. , Tate Janet P. ,   for the Veterans Aging Cohort Study
Published: January 2024

IntroductionAs people age with HIV (PWH), many comorbid diseases are more common than among age matched comparators without HIV (PWoH). While the Veterans Aging Cohort (VACS) Index 2.0 accurately predicts mortality in PWH using age and clinical biomarkers, the only included comorbidity is hepatitis C. We asked whether adding comorbid disease groupings from the Charlson Comorbidity Index (CCI) improves the accuracy of VACS Index.MethodsTo maximize our ability to model mortality among older age groups, we began with PWoH in Veterans Health Administration (VA) from 2007–2017, divided into development and validation samples. Baseline predictors included age, and components of CCI and VACS Index (excluding CD4 count and HIV RNA). Patients were followed until December 31, 2021. We used Cox models to develop the VACS-CCI score and estimated mortality using a parametric (gamma) survival model. We compared accuracy using C-statistics and calibration curves in validation overall and within subgroups (gender, age &lt;/≥65 years, race/ethnicity, and CCI score). We then applied VACS-CCI in PWH and compared its accuracy to age, VACS Index 2.0, CCI and VACS-CCI with CD4 and HIV RNA added.ResultsThe analytic sample consisted of 6,588,688 PWoH and 30,539 PWH. Among PWoH/PWH, median age was 65/55 years; 6%/3% were women; 15%/48% were Black and 5%/7% Hispanic. VACS-CCI provided the best discrimination (C-statistic = 0.81) with excellent calibration (predicted and observed mortality largely overlapped) overall and within subgroups. When VACS-CCI was applied to PWH it demonstrated similar discrimination as VACS Index 2.0 (C-statistic = 0.77 for both) but superior calibration among those with CD4 &lt; 200. Discrimination was improved when CD4 and HIV RNA were added VACS-CCI (C-statistic = 0.79). Liver and kidney disease, congestive heart failure, malignancy, and dementia were negatively associated with CD4 (p-trends all &lt;0.0001).DiscussionAmong PWH and PWoH in VA care, age alone weakly discriminates risk of mortality. VACS Index 2.0, CCI, and VACS-CCI all provide better discrimination, but VACS-CCI is more consistently calibrated. The association of comorbid diseases with lower CD4 underscores the likely role of HIV in non-AIDS conditions. Future work will include adding CD4 and HIV RNA to VACS-CCI and validating it in independent data.
Association between acetaminophen administration and clinical outcomes in patients with sepsis admitted to the ICU: a retrospective cohort study
Authors: Sun Shilin , Liu Han , Liang Qun , Yang Yang , Cao Xuedan , Zheng Boyang 
Published: January 2024

BackgroundSepsis, affecting over 30 million people worldwide each year, is a key mortality risk factor in critically ill patients. There are significant regional discrepancies in its impact. Acetaminophen, a common over-the-counter drug, is often administered to control fever in suspected infection cases in intensive care units (ICUs). It is considered generally safe when used at therapeutic levels. Despite its widespread use, there’s inconsistent research regarding its efficacy in sepsis management, which creates uncertainties for ICU doctors about its possible advantages or harm. To address this, we undertook a retrospective cohort study utilizing the MIMIC-IV database to examine the correlation between acetaminophen use and clinical outcomes in septic patients admitted to the ICU.MethodsWe gathered pertinent data on sepsis patients from the MIMIC-IV database. We used propensity score matching (PSM) to pair acetaminophen-treated patients with those who were not treated. We then used Cox Proportional Hazards models to examine the relationships between acetaminophen use and factors such as in-hospital mortality, 30-day mortality, hospital stay duration, and ICU stay length.ResultsThe data analysis involved 22,633 sepsis patients. Post PSM, a total of 15,843 patients were matched; each patient not receiving acetaminophen treatment was paired with two patients who received it. There was a correlation between acetaminophen and a lower in-hospital mortality rate (HR 0.443; 95% CI 0.371–0.530; p &lt; 0.001) along with 30-day mortality rate (HR 0.497; 95% CI 0.424–0.583; p &lt; 0.001). Additionally, it correlated with a decrease in the duration of hospitalization [8.4 (5.0, 14.8) vs. 9.0 (5.1, 16.0), p &lt; 0.001] and a shorter ICU stay [2.8 (1.5, 6.0) vs. 3.1 (1.7, 6.5); p &lt; 0.05].ConclusionThe use of acetaminophen may lower short-term mortality in critically ill patients with sepsis. To confirm this correlation, future research should involve multicenter randomized controlled trials.
Outcomes of whole-body photobiomodulation on pain, quality of life, leisure physical activity, pain catastrophizing, kinesiophobia, and self-efficacy: a prospective randomized triple-blinded clinical trial with 6 months of follow-up
Authors: Navarro-Ledesma Santiago , Carroll James D. , González-Muñoz Ana , Burton Patricia 
Published: January 2024

BackgroundThe management of fibromyalgia (FM) symptoms on a global scale remains a complex endeavor. This study endeavors to assess the impact of whole-body photobiomodulation (PBM) compared to placebo PBM on pain, functionality, and psychological symptoms in individuals afflicted with fibromyalgia.ObjectivesThe primary objectives of this research were to conduct a comparative analysis of the effects of whole-body photobiomodulation (PBM) and placebo PBM on pain, functionality, and psychological symptoms in patients suffering from fibromyalgia (FM).MethodsA total of 42 subjects were recruited from a private care practice for participation in this triple-blinded, placebo-controlled, randomized clinical trial. Participants underwent 12 treatment sessions, and assessments were conducted at various intervals, including baseline (T0), midway through the 12-session treatment (T1), at the completion of the 12 sessions (T2), and follow-ups at 2 weeks (T3), 3 months (T4), and 6 months (T5).ResultsStatistical analysis revealed significant reductions in pain at T2, T3, and T5. Additionally, quality of life exhibited marked improvements after sessions at T1, T2, T3, T4, and T5. Leisure activity also demonstrated statistically significant improvements at T2, T3, T4, and T5. Furthermore, kinesiophobia showed significant differences between groups immediately after treatment at T2, T3, T4, and T5. Self-efficacy, when compared between groups, demonstrated significant differences at T3, T4, and T5 (two weeks after treatment). Lastly, pain catastrophizing exhibited significant differences only at T5.ConclusionThe findings of this study indicate that whole-body PBM treatment for 4 weeks resulted in significant pain reduction and improved quality of life in individuals suffering from FM. Furthermore, kinesiophobia and self-efficacy demonstrated improvements in both short-term and long-term assessments, while pain catastrophizing showed improvement at the 6-month follow-up. Consequently, whole-body PBM emerges as a promising multifactorial treatment option for FM patients, though further studies are required to validate and strengthen these results.Clinical Trial Registration:Clinicaltrials.gov, NCT0424897.
Association between obesity and age-related cataract: an updated systematic review and dose–response meta-analysis of prospective cohort studies
Authors: Niazi Sana , Moshirfar Majid , Dastjerdi Mohammad H. , Niazi Feizollah , Doroodgar Farideh , Ambrósio Renato 
Published: January 2024

ObjectiveThere are inconsistent findings on the association between obesity and age-related cataract (ARC). This systematic review was done to summarize available findings on the association between obesity [defined by body mass index (BMI)] and ARC by performing a dose–response meta-analysis on eligible prospective cohort studies.MethodsWe performed a systematic search in PubMed, Scopus, ISI Web of Knowledge, and Google Scholar until June 2022 to identify eligible publications.ResultsIn total, 16 studies with a total sample size of 1,607,125 participants were included. Among all of these studies, there were 103,897 cases of ARC. In the follow-up periods ranging between 4 and 28 years, 4,870 cases of nuclear cataract, 1,611 cases of cortical cataract, and 1,603 cases of posterior subcapsular cataracts (PSC) were detected. By comparing the highest and lowest categories of BMI, we found that higher BMI was associated with an increased risk of ARC (RR: 1.18, 95% CI: 1.09–1.28) and PSC (RR: 1.44, 95% CI: 1.08–1.90). In the dose–response analysis, each 5 kg/m2 increase in BMI was associated with a 6 and 27% increased risk of ARC (RR: 1.06, 95% CI: 1.01–1.12) and PSC (RR: 1.27, 95% CI: 1.14–1.41), respectively. In addition, we found a positive association for cortical cataract among high-quality studies, in which higher BMI was associated with a 20% increased risk of cortical cataract (RR: 1.20, 95% CI: 1.02–1.42). In terms of nuclear cataract, we found no significant association either in the comparison between the highest and lowest categories of BMI or in the dose–response meta-analysis.ConclusionObesity (defined by BMI) was associated with an increased risk of ARC, PSC, and cortical cataract in adults. However, such a positive association was not seen for nuclear cataract.PROSPERO registrationCRD42022357132.