bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy analysis of the off-label use of pipeline embolization devices for intracranial aneurysms: a propensity score matching study
Authors: Ma Yajing , Deng Xin , Chen Zhen , Yuan Yongjie , Guan Sheng , Guo Xinbin 
Published: January 2024

Background and objectiveThe safety and efficacy of on-label use of pipeline embolization devices (PEDs) are well established; however, there is much controversy over their off-label use. This study aimed to investigate the safety and efficacy of the off-label use of PEDs for treating intracranial aneurysms.MethodsThis single-center study retrospectively included patients with digital subtraction angiography, computed tomographic angiography, or magnetic resonance angiography confirmed intracranial aneurysms treated with PEDs who were admitted to our institution between 1 January 2018 and 1 July 2022. Patients were divided into on- and off-label groups according to the Food and Drug Administration criteria published in 2021. Propensity score matching (PSM) was used to balance disparities in baseline information between the two groups. Safety outcomes included postoperative mortality and complication rates, whereas effectiveness outcomes included aneurysm occlusion rate (O’Kelly-Marotta grading system C + D grades), retreatment rate within 12 months, and postoperative functional score [modified Rankin scale (mRS) score]. The study was approved by the Ethics Committee of Scientific Research and Clinical Trial of the First Affiliated Hospital of Zhengzhou University (Ethics number: KY 2018–098-02). All patients provided informed consent.ResultsA total of 242 patients with 261 aneurysms (160 on-label and 101 off-label aneurysms) were included in this study. PSM yielded 81 pairs of patients matched for baseline information. Postoperative hemorrhagic, ischemic, and procedure-related complication rates did not reach statistical significance. In addition, no statistically significant differences in the aneurysm occlusion rate, retreatment rate within 12 months, postoperative functional score (mRS score), or mRS score deterioration rate were observed between the two groups. A higher incidence of in-stent stenosis was observed in the off-label (4.9% vs. 21%, p = 0.002) group than in the on-label group; however, all patients were asymptomatic.ConclusionCompared with on-label use, off-label use of PEDs for treating intracranial aneurysms did not increase the risk of complications, and the occlusion rates were comparable. Therefore, decisions regarding clinical management should not rely solely on on- or off-label indications.
Impact of smoking status on health-related quality of life (HRQoL) in cancer survivors
Authors: Nolazco José Ignacio , Rosner Bernard A. , Roebuck Emily H. , Bergerot Cristiane Decat , Rammant Elke , Iyer Geetha S. , Tang Yuzhe , Al-Faouri Ra’ad , Filipas Dejan K. , Leapman Michael S. , Mossanen Matthew , Chang Steven Lee 
Published: January 2024

IntroductionThe Health-Related Quality of Life (HRQoL) often declines among cancer survivors due to many factors. Some cancer patients who smoke before the cancer diagnosis continue this harmful habit, potentially contributing to a more significant decline in their HRQoL. Therefore, this study investigates the association between smoking status and HRQoL in cancer survivors.MethodsWe conducted a cross-sectional study utilizing self-reported cancer history from 39,578 participants of the Behavioral Risk Factor Surveillance System (BRFSS) database, leveraging 2016 and 2020 year questionaries. A multidimensional composite outcome was created to assess HRQoL, integrating four distinct dimensions - general health, mental health, physical health, and activity limitations. After accounting for the complex survey design, logistic regression models were used to analyze the association between smoking status and poor HRQoL, adjusting for demographic, socioeconomic, and health-related confounders.ResultsOur study found that, after adjusting for potential confounders, current smokers exhibited a significantly poorer HRQoL than never smokers (OR 1.65, 95%CI 1.40-1.93). Furthermore, former smokers showed a poorer HRQoL than never smokers; however, this association was not as strong as current smokers (OR 1.22, 95%CI 1.09-1.38).ConclusionOur findings highlight the adverse association of smoking with poor HRQoL in cancer survivors, underscoring the importance of healthcare professionals prioritizing smoking cessation and providing tailored interventions to support this goal.
Prognostic analysis of extrameningeal solitary fibrous tumor using the modified Demicco model: a clinicopathologic study of 111 Chinese cases
Authors: Yao Chen-chen , Zhou Jian , Li Xiao , Yang Jun , Chen Gang , Wei Jia , Fan Qin-he , Gong Qi-xing 
Published: January 2024

IntroductionSolitary fibrous tumor (SFT) represents a fibroblastic neoplasm exhibiting NAB2::STAT6 gene rearrangement, displaying diverse clinical manifestations, spanning from benign to malignant. To predict prognosis, the modified (four-variable) Demicco (mDemicco) model was introduced. This investigation aims to authenticate the mDemicco risk model’s precision in Asian patients while investigating the clinicopathological and molecular factors linked to the prognosis of extrameningeal SFTs.MethodsClinicopathological data from 111 extrameningeal SFT cases in East China, covering the period from 2010 to 2020, were thoroughly analyzed. The tumors were classified using the mDemicco model. Immunohistochemical evaluation of P16 and P53, molecular detection of TP53 and TERT promoter mutation, and fluorescence in situ hybridization for CDKN2A gene alterations were performed. Statistical methods were utilized to assess the associations between clinicopathological or molecular factors and prognosis.ResultsHistologically, only one parameter, the mitotic count, exhibited a statistical correlation with progression-free survival (PFS) and overall survival (OS). During the Kaplan-Meier analysis, the variation in PFS among the different risk groups exhibited a notable trend towards statistical significance. Nevertheless, 3 out of 74 patients classified as low-risk SFTs and 7 out of 21 patients classified as intermediate-risk exhibited disease progression. Among the 5 patients with TP53 mutations and/or mutant-type P53 immunophenotype, 3 experienced disease progression, including 2 intermediate-risk patients. Additionally, among the 4 patients with TERT promoter mutations who were followed up, 3 showed progression, including 2 intermediate-risk patients. Moreover, it was observed that hemizygous loss of CDKN2A was detected in more than 30% of one case, yet the patient exhibited a favorable survival outcome.ConclusionThe mDemicco risk model exhibits certain limitations when dealing with smaller tumor sizes, younger age groups, and occurrences of malignant and dedifferentiated SFTs. Furthermore, molecular factors, such as TP53 or TERT promoter mutations, may identify intermediate-risk SFTs with poorer prognoses.
Splenogonadal fusion: a case report of three cases and a literature review
Authors: Luo Na , Xu Qitao , Wang Hao , Su Jiahong , Li Shoulin 
Published: January 2024

PurposeThis case report aims to enhance the understanding of clinical physicians regarding splenogonadal fusion (SGF) and to help them consider SGF as a differential diagnosis when testicular tumors are suspected, thus avoiding unnecessary orchiectomies.MethodsWe report three cases of SGF admitted to our hospital, one of which presented as a suspected testicular tumor. We also searched the literature on scrotal masses from the last 25 years and summarize the characteristics of cases of SGF manifesting as scrotal swelling combined with our cases.ResultsAfter conducting a thorough search, we found a total of 24 publications relevant to this case study, which included 25 testes. All lesions were located on the left side, and the average age of those affected was 20.22 years. Seven cases were of the continuous type. Three cases presented with pain, all of which were intratesticular masses. Thirty cases had a definite onset duration, ranging from 3 weeks to 10 years. Nine patients (36%) underwent orchiectomy, and one underwent partial orchiectomy.ConclusionIt is crucial to identify SGF in the clinic. When a patient presents with scrotal swelling, diagnosing SGF preoperatively is challenging, and it should be considered when there is a long history of a stable testicular mass. An intraoperative frozen section should be performed if a testicular tumor is suspected to avoid unnecessary orchiectomy.
Phytochemical and biological studies of Panicum antidotale aerial parts ethanol extract supported by molecular docking study
Authors: Sarwar Imtisal , Asif Muhammad , Jamshaid Talha , Saadullah Malik , Zubair Hafiz Muhammad , Saleem Mohammad , Jamshaid Usama , Youssef Fadia S. , Ashour Mohamed L. , Elhady Sameh S. 
Published: January 2024

Panicum antidotale has traditionally been used as a poultice to alleviate local inflammation and painful diseases. This study aimed to evaluate the anti-inflammatory, wound-healing, analgesic, and antipyretic potential of its ethanol extract (PAAPEE) in vivo for the first time. In vitro antioxidant assays of Panicum antidotale using a 2,2-diphenyl-1-picrylhydrazyl assay revealed that it showed IC50 of 62.50 ± 6.85 μg/mL in contrast to standard, ascorbic acid, that showed IC50 of 85.51 ± 0.38 μg/mL. Administration of PAAPEE at a dose of 500 mg/kg (PAAPEE-500) displayed 78.44% and 75.13% inhibition of paw edema in carrageenen and histamine-induced edema models. respectively, 6 h post-treatment compared to that of the untreated group. Furthermore, it showed 68.78% inhibition of Freund’s complete adjuvant-induced edema 21 days after treatment. It reduced the animal’s rectal temperature in the yeast-induced fever model to 99.45 during the fourth h post-treatment. It significantly inhibited abnormal writhing by 44% in the acetic acid-induced pain model. PAE-500 also showed enhancement in wound closure by 72.52% with respect to that of the untreated group on the 10th day post-treatment using the excision healing of wound model. Histopathological examination of skin samples confirmed this improvement, showing enhanced tissue architecture with minimal infiltration of inflammatory cells. High-performance liquid chromatography (HPLC) of PAAPEE revealed the presence of quercetin, gallic, p-coumaric, benzoic, chlorogenic, syringic, ferulic, cinnamic, and sinapic acids. Molecular docking of 5-lipoxygenase and glycogen synthase kinase-3 β protein indicated their potential interaction within the active sites of both enzymes. Thus, P. antidotale serves as an effective natural wound-healing, anti-inflammatory, analgesic, and antipyretic agent.
Quality evaluation of four Ferula plants and identification of their key volatiles based on non-targeted metabolomics
Authors: Jiang Meng , Peng Mengwen , Li Yuxia , Li Guifang , Li Xiaobo , Zhuang Li 
Published: January 2024

IntroductionFerula is a traditional, edible, and important medicinal plant with high economic value. The distinction between edible and non-edible Ferula remains unclear.MethodsIn this study, headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry (HS-SPME/GC-MS) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) non-targeted metabolomics techniques were used to systematically and comprehensively analyse secondary metabolites in the leaves and roots of four species of Ferula, considering their edibility.ResultsA total of 166 leaf volatile organic compounds (VOCs) and 1,079 root metabolites were identified. Additionally, 42 potential VOCs and 62 differential root metabolites were screened to distinguish between edible and non-edible Ferula. Twelve volatile metabolites were specific to F. feurlaeoides, and eight compounds were specific to the three edible Ferula species. The results showed that compounds containing sulphur, aldehydes, and ketones, which produce pungent odours, were the primary sources of the strong odour of Ferula. The root differential metabolites include 13 categories, among which the high concentration group is organic acids, amino acids, terpenoids and fatty acids. The bioactive metabolites and VOCs in the roots exhibited species-specific characteristics. VOCs with various odors were linked to the distribution of root metabolites in both edible and non-edible Ferula plants. The screened root markers may contribute to the formation of characteristic VOCs.DiscussionThis study identified the difference in flavour between edible and non-edible Ferula plants and, for the first time, demonstrated the contribution of the efficacy of Ferula root to the unique flavour of the above-ground parts of Ferula. These results provide a theoretical basis for selecting Ferula for consumption and help evaluate the quality of different species of Ferula. Our findings may facilitate food processing and the further development of Ferula.
Youth recidivism: youth self-report matters
Authors: Holloway Evan D. , Irgens Megan , McPhee Jeanne , Folk Johanna B. , Tolou-Shams Marina 
Published: January 2024

Introduction“Recidivism” is used ubiquitously in juvenile justice research and typically describes repeat legal contact; however, researchers, policymakers, and clinicians operationalize it in various ways. Despite assuming each measure is a proxy for continued delinquent behavior leading to further legal contact, few have examined the association between youth delinquent behavior and self-reported and official records of legal contact. Furthermore, systemic bias against ethnoracial and gender minoritized youth often results in more harsh treatment by the legal system, which could influence recidivism measurement. Latent variable modeling of legal contact is understudied; thus, it is important to examine the feasibility of measuring this construct as a latent variable, including measurement invariance by gender.MethodsAmong 401 youth ages 12–18 years at first ever court contact, we examined three metrics of legal contact over a 2-year follow-up period: youth-report of arrest, caregiver-report of their adolescent’s arrest, and official records of the number of new court charges. We examined between-group differences on each metric based on gender and ethnoracial identity. We then measured: (1) the association between youths’ self-reported delinquency and each metric, (2) gender-specific associations between self-reported delinquency and each metric, and (3) gender-based measurement invariance for a latent recidivism variable using confirmatory factor analysis.ResultsYouth were consistent reporters of their own delinquent behavior and prospective legal contact measured by arrests. There were no between-group differences based on gender or ethnoracial identity for any legal contact measures. Delinquency and all legal contact variables were positively intercorrelated for the overall sample and the male subsample. For females, delinquency was not associated with caregiver-reported youth arrest or number of new charges. The latent legal contact variable had unique factor structures for male and female subsamples, suggesting no measurement invariance.DiscussionYouth-reported delinquency at first ever legal contact was most strongly associated with youth-reported arrest during a 2-year follow-up period, followed by caregiver-reported arrest, and the number of new charges. Unique latent variable factor structures for male and female subsamples suggests the inter-relation between legal contact variables is gender-specific. Stakeholders should consider prioritizing youth-reported delinquency since it is most strongly related to prospective youth-reported arrest.
Association between suicidal ideation and tandem repeats in contactins
Authors: Parikh Kairavi , Quintero Reis Andrea , Wendt Frank R. 
Published: January 2024

BackgroundDeath by suicide is one of the leading causes of death among adolescents. Genome-wide association studies (GWAS) have identified loci that associate with suicidal ideation and related behaviours. One such group of loci are the six contactin genes (CNTN1-6) that are critical to neurodevelopment through regulating neurite structure. Because single nucleotide polymorphisms (SNPs) detected by GWAS often map to non-coding intergenic regions, we investigated whether repetitive variants in CNTNs associated with suicidality in a young cohort aged 8 to 21. Understanding the genetic liability of suicidal thought and behavior in this age group will promote early intervention and treatment.MethodsGenotypic and phenotypic data were obtained from the Philadelphia Neurodevelopment Cohort (PNC). Across six CNTNs, 232 short tandem repeats (STRs) were analyzed in up to 4,595 individuals of European ancestry who expressed current, previous, or no suicidal ideation. STRs were imputed into SNP arrays using a phased SNP-STR haplotype reference panel from the 1000 Genomes Project. We tested several additive and interactive models of locus-level burden (i.e., sum of STR alleles) with respect to suicidal ideation. Additive models included sex, birth year, developmental stage (“DevStage”), and the first 10 principal components of ancestry as covariates; interactive models assessed the effect of STR-by-DevStage considering all other covariates.ResultsCNTN1-[T]N interacted with DevStage to increase risk for current suicidal ideation (CNTN1-[T]N-by-DevStage; p = 0.00035). Compared to the youngest age group, the middle (OR = 1.80, p = 0.0514) and oldest (OR = 3.82, p = 0.0002) participant groups had significantly higher odds of suicidal ideation as their STR length expanded; this result was independent of polygenic scores for suicidal ideation.DiscussionThese findings highlight diversity in the genetic effects (i.e., SNP and STR) acting on suicidal thoughts and behavior and advance our understanding of suicidal ideation across childhood and adolescence.
Empowering 6G maritime communications with distributed intelligence and over-the-air model sharing
Authors: Zetas Menelaos , Spantideas Sotirios , Giannopoulos Anastasios , Nomikos Nikolaos , Trakadas Panagiotis 
Published: January 2024

Introduction: Shipping and maritime transportation have gradually gained a key role in worldwide economical strategies and modern business models. The realization of Smart Shipping (SMS) powered by advanced 6G communication networks, as well as innovative Machine Learning (ML) solutions, has recently become the focal point in the maritime sector. However, conventional centralized learning schemes are unsuitable in the maritime domain, due to considerable data communication overhead, stringent energy constraints, increased transmission failures in the harsh propagation environment, as well as data privacy concerns.Methods: To overcome these challenges, we propose the joint adoption of Federated Learning (FL) principles and the utilization of the Over-the-Air computation (AirComp) wireless transmission framework. Thus, this paper initially describes the mathematical considerations of a 6G maritime communication system, focusing on the heterogeneity of the relevant nodes and the channel models, including an Unmanned Aerial Vehicle (UAV)-aided relaying model that is usually required in maritime communications. The communication network, enhanced with the AirComp technique for efficiency purposes, forms the technical basis for the collaborative learning across multiple Internet of Maritime Things (IoMT) nodes in FL tasks. The workflow of the FL/AirComp scheme is illustrated and proposed as a communication-efficient and privacy-aware SMS framework, considering spectrum and energy efficiency aspects under a sum transmitting power constraint.Results: Then, the performance of the proposed methodology is assessed in an important ML task, related to intelligent maritime transportation systems, namely, the prediction of the Cargo Ship Propulsion Power using real data originating from six cargo ships and utilizing long-short-term-memory (LSTM) neural networks. Upon extensive experimentation, FL showed higher prediction accuracy relative to the typical Ensemble Learning technique by a factor of 3.04. The AirComp system performance was evaluated under varying noise conditions and number of IoMT nodes, using simulation data for the channel state information by regulating the power of the transmitting IoMT entities and the scaling factor at the shore base station.Discussion: The results clearly indicate the efficiency of the proposed FL/AirComp scheme in achieving low computation error, collaborative learning, spectrum efficiency and privacy protection in wireless maritime communications, while providing adequate accuracy levels with respect to the optimization objective.
SWI/SNF chromatin remodelers in prostate cancer progression
Authors: Ordonez-Rubiano Sandra C. , Strohmier Brayden P. , Sood Surbhi , Dykhuizen Emily C. 
Published: January 2024

Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer-related deaths in men in the US. The majority of PCa cases arise in the luminal cells of the prostate and develop into adenocarcinoma. Primary PCas are heterogeneous and have alterations in a variety of tumor suppressors and oncogenes; however, the vast majority are dependent on gene expression regulation by androgen receptor (AR), making it the focus for most targeted therapy development. As the incidence of PCa cases resistant to AR-targeted therapies rises, there is renewed attention on how additional genetic and epigenetic alterations contribute to PCa progression and resistance. In this review we summarize the efforts made over the past 20 years to dissect the function of the SWI/SNF chromatin remodelers in PCa. We mainly focus on how SWI/SNF complexes regulate different aspects of AR signaling, facilitate other key drivers in PCa, promote the advancement of the disease, and regulate the tumor microenvironment.