bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of a brinzolamide/brimonidine fixed combination on optic nerve head blood flow in rabbits
Authors: Takahashi Nana , Sato Kota , Kiyota Naoki , Yamazaki Mai , Kunikane Eriko , Nakazawa Toru 
Published: December 2023

Purpose
The purpose of this study was to investigate the effect of a 1% brinzolamide and 0.1% brimonidine fixed combination (BBFC) on ONH blood flow (BF) in rabbits.

Methods
A crossover study was conducted on pigmented rabbits; a physiological saline solution, brinzolamide, or BBFC was administered for eight days. ONH BF, intraocular pressure (IOP) and systemic parameters were measured before the eighth day’s first dose and at 6, 9, 12, and 14 hours after the dose. ONH BF was assessed using laser speckle flowgraphy, and mean blur rate (MBR) values were calculated. The percentage against baseline of each parameter was calculated, and intergroup comparisons were performed at each time point.

Results
There were no significant differences in the percentage change in systemic parameters. At 6 hours after administration, the BBFC group showed a significantly higher percentage change in large vessel area-MBR (%MV) compared to the control group (98.6±16.8%MV vs. 81.3±7.9%MV, P = 0.03). On the other hand, the brinzolamide group did not show a significant difference. Both the brinzolamide and BBFC groups had significantly lower percentage change in IOP (%IOP) compared to the control group (90.6±5.0%IOP, 93.3±2.9%IOP, and 99.2±1.7%IOP, respectively, P < 0.01).

Conclusion
BBFC effectively reduces IOP and mitigates diurnal fluctuation-induced decreases in ONH BF.
integración de egresados en un ecosistema publicitario local: el caso de Alicante
Authors: Poveda Salvá Miquel , Vizcaíno Alcantud Pablo 
Published: December 2023

No existe una normativa legal que impida el desempeño profesional de la actividad publicitaria si no se dispone de la titulación universitaria de Publicidad y Relaciones Públicas. El intrusismo en esta área se vincula, más bien, a la necesidad de contar con la formación y preparación necesarias. Ahí radica la utilidad del actual grado universitario: será más o menos valioso en la medida que proporcione la formación que se requiere para desempeñar adecuadamente la profesión y responder de forma satisfactoria a las nuevas demandas que generan los profundos cambios en el sector comunicativo. Es evidente, por tanto, que el interés por seleccionar el grado como vía formativa, así como la posterior capacidad de empleabilidad de los egresados y egresadas, estará vinculado a la idoneidad del grado.
Por ese motivo es necesario que las universidades profundicen en el conocimiento de las exigencias cambiantes en el sector y muestren la agilidad suficiente para adaptar sus planes de estudio.
En este estudio, tras la realización de dos encuestas de carácter cuantitativo y una batería de entrevistas en profundidad, se plantea conocer el encaje de egresados y egresadas de Publicidad y Relaciones Públicas de la UA en el ecosistema de agencias de publicidad de la provincia de Alicante, así como el efecto que ha supuesto la existencia de estudios universitarios en el sector.
Prophylactic efficacy of 400 vs. 200 mg/kg /day calcium gluconate to prevent neonatal hypocalcemia
Authors: Apsera Liza , Sianturi Pertin , Nafianti Selvi 
Published: December 2023

Background Serum calcium is at its lowest level within 24–48 hours after birth, rendering the neonate vulnerable to hypocalcemia. In our center, despite prophylactic administration of 200 mg/kg/day calcium gluconate, the prevalence of neonatal hypocalcemia remains high.
Aim To determine the prophylactic efficacy of 400 vs. 200 mg/kg/day calcium gluconate in preventing neonatal hypocalcemia.
Methods A randomized clinical trial with a pre- and post-test experimental design was done on neonates who fasted or received only minimal enteral feeding. Subjects were randomized to receive either 400 mg/kg/day (intervention group) or 200 mg/kg/day (control group) of intravenous calcium gluconate. We compared serum ionized calcium levels on the first day of admission before calcium gluconate administration and on the third day of hospitalization between the intervention and control groups.
Results The median ionized calcium levels in the intervention vs. control group before calcium gluconate administration was 1.16 (range 0.4-2.4) mmol/L vs. 1.15 (range 0.6-4.5) mmol/L , respectively (P=0.561). After three days of calcium gluconate administration, the median ionized calcium level was 1.19 (range 0.7-1.45) mmol/L vs. 1.19 (range 0.68-4.6) mmol/L in the intervention vs. control group, respectively (P=0.828). The difference in pre- vs. post-administration ionized calcium levels was significant within the intervention group (P=0.032), but not within the control group (P=0.128).
Conclusion Prophylactic intravenous calcium gluconate at 400 mg/kg/day was not more effective in preventing neonatal hypocalcemia than 200 mg/kg/day.
Maternal barriers to stimulating early childhood development on Tidore Island
Authors: Kusila Gilbert Renardi 
Published: December 2023

Background The first 5 years of life provide a foundation for neuroplastic development, which establishes the capacity to accomplish complicated tasks in later life. However, this period is vulnerable to multiple stressors and adversities that prevent children from achieving age-related developmental milestones. Mothers as primary caregivers may find it challenging to engage her child in stimulating activities.
Objectives To understand maternal barriers to stimulating early childhood development and potential interventions that can be developed.
Methods This explorative, qualitative study was conducted in 13 different service coverage areas of the Soasio Community Health Center (Puskesmas), Tidore Islands, North Maluku, Indonesia. A total of 30 mothers participated in structured interview sessions. The analysis was conducted inductively, by generating some key issues from the interview.
Results Eight maternal barriers to engaging in child stimulation activities were found: (1) family members, (2) gender-related interaction, (3) partial understanding of child health-related information, (4) prioritizing one developmental achievement over others, (5) timidity in decision making, (6) delaying stimulation due to overreliance on the role of school, (7) responsive feeding, and (8) media. Maternal motivation, societal awareness of child development, and support of maternal and family mental health are needed to improve maternal engagement in child stimulation.
Conclusions Family, community, and life experiences may become maternal barriers to stimulating childhood development. Providing better social support, information access, and woman empowerment in decision-making will help mothers to be more engaged in child development stimulation activities.
Optic nerve sheath diameter and severity of central nervous infection
Authors: Dewi Anggun Puspita , Lukmanul Hakim Dzulfikar Djalil , Rahayuningsih Sri Endah , Risan Nelly Amalia , Ghrahani Reni , Adrizain Riyadi 
Published: December 2023

Background Central nervous system (CNS) infection affects the brain, and can cause cerebral edema, increased intracranial pressure (ICP), cerebral herniation, and death. Measurement of the optic nerve sheath diameter (ONSD) by ultrasound is a new, non–invasive examination to predict ICP, with high sensitivity and specificity.Objective To analyze for a possible association between ONSD measured by ultrasonographic examination and severity of CNS infection.
Methods This cross–sectional study was performed in the Pediatric Department of Hasan Sadikin Hospital, Bandung, West Java. Subjects were chosen by consecutive sampling. We measured ONSD, examined clinical manifestations, as well as performed a cerebrospinal fluid (CSF) study and imaging of CNS infection. Data analysis was done by paired T–test and one–way ANOVA, followed by Tukey test on significant variables.
Results Subjects consisted of 32 children with CNS infection. The most common clinical symptoms were fever, decreased consciousness, and nuchal rigidity. Bivariate analysis revealed strong positive associations between ONSD and Glasgow Coma Scale (GCS), increased protein levels in CSF, and type of CNS infection.
Conclusion Larger ONSD is significantly associated with lower GCS, increases CSF protein, and particular CNS infections. The ONSD is also associated with meningitis tuberculosis grade III, with a higher mean ONSD of both eyes compares to other CNS infections. Hence, the higher the ONSD, the more severe the degree of CNS infection.
meio ambiente e o descarte de resíduos
Authors: Bem Judite Sanson , Menezes Jéssica Alberche de , Cademartori Cristina Vargas 
Published: December 2023

The environment and waste disposal: study of the legislation in the RMPA regarding the prohibition of plastic straws in the metropolitan region of Porto Alegre
O objetivo desta pesquisa é investigar, a partir de dados secundários, quais os municípios da RMPA que apresentam alguma legislação relacionada ao uso de canudos plásticos e analisá-las. O plástico foi criado no início do século XX e, desde então, a indústria deste material só cresceu. Apesar deste material ser leve, barato e durável, causa problemas ao meio ambiente, pois se acumula, ao longo do tempo, provocando poluição e difícil degradação. Os canudos são feitos de plásticos e seu tempo de consumo não ultrapassa 15 minutos o que se traduz em uma relação custo/benefício altíssima. Do ponto de vista dos procedimentos metodológicos, esta pesquisa foi inicialmente documental e bibliográfica, através de livros, artigos, pesquisa na internet em sites do IBGE, da ABRELPE, ABIPLAST e pesquisas realizadas nas prefeituras. Ainda, foi realizado um levantamento da legislação dos municípios da Região Metropolitana de Porto Alegre (RMPA) quanto à exigência de lei de proibição dos canudos plásticos ou de projeto de lei neste sentido que esteja em tramitação na Câmara. Dos 34 municípios avaliados concluiu-se que 18 não possuem nenhuma lei ou projeto de lei relacionado à proibição dos canudos plásticos, 15 municípios possuem lei e apenas um município possui um projeto de lei. Todos os municípios que possuem esse tipo de legislação apresentam alternativas sustentáveis para a substituição, como canudos de papel e de material biodegradável.
Governo aberto na produção científica em ciência da informação
Authors: Sena Priscila Machado Borges , Ribeiro Nivaldo Calixto , Melo Bianca Amaro de , Carvalho Segundo Washington Luís Ribeiro de 
Published: December 2023

Estabelece-se para este capítulo o objetivo de reconhecer na produção científica brasileira em Ciência da Informação os tipos de abordagens em torno da Parceria para Governo Aberto (Open Government Partnership – OGP). Efetuou-se uma revisão rápida da literatura, no dia 25 de maio de 2022, com busca estruturada na Base de Dados em Ciência da Informação (BRAPCI), com o termo "Governo Aberto" em todos os campos dos documentos. Encontrou-se 39 documentos. Eliminados os documentos oriundos de eventos e as duplicações, a busca resultou em 34 documentos. Após a leitura do resumo, para identificação do alinhamento ao escopo deste trabalho, selecionou-se 24 documentos. Na fase de análise de dados, utilizou-se o modelo proposto por Oliveira em 2008, composto por três etapas: 1. Pré-análise, 2. Exploração do material ou codificação e, 3. Tratamento dos resultados. Foram estabelecidas cinco unidades de análise: Acesso à informação, Dados abertos, Gestão, Governo Aberto, e Recursos tecnológicos abertos. Conclui-se que, se por um lado há identificações e busca de suporte teórico na Ciência da Informação, por outro há aplicações de métodos e ferramentas com a finalidade de garantir o fortalecimento das ações de Governo Aberto e o acesso da sociedade à informações com efetividade e eficiência.
EDUCAÇÃO BÁSICA
Authors: Ferreira Jany Fabia , Paes Lucilene da Silva 
Published: December 2023

O processo da experimentação no ensino de ciências deve proporcionar o meio de motivação para o aprendizado no dia a dia na escola, de uma maneira que possibilite o professor estimular o desenvolvimento cognitivo do seu aluno, mas para isso é necessário observar a realidade com as quais o docente trabalha e vivencia suas experiências pedagógicas. Neste artigo apresentamos relatos sobre os desafios enfrentados por professores de ciências da educação básica no ensino fundamental anos finais na região norte do Brasil, quanto ao processo de ensino e aprendizagem sobre a prática da experimentação, tendo como base uma pesquisa de forma qualitativa com método exploratório realizado por meio de levantamento de dados com docentes sobre experiências profissionais nas aulas de ciências e de acordo com resultado foi evidenciado impasses no que se refere o processo de aprendizado por meio da atividade prática.
Palavras-chave: Experimentação. Ciências. Desafios. Professor.
Sustentabilidade e educação
Authors: Rosa Marina Comerlatto da , Antiqueira Lia Maris Orth Ritter 
Published: December 2023

Este estudo bibliográfico aborda as contribuições do pensamento freiriano nas discussões sobre sustentabilidade baseando-se na relação ser humano – planeta. Fundamenta-se em Gadotti (2005, 2009), Boff (2012), Loureiro (2012), Capitango e Callejas (2019), Freire (1959, 1989, 1995, 1996, 1997, 2000, 2001, 2005, 2016) e Brandão (2005, 2014). A temática socioambiental não é uma discussão explícita nos textos de Paulo Freire, no entanto percebe-se o constante cuidado, afeto e a responsabilidade para com o tema. A educação freiriana, enquanto meio de compreensão da relação sociedade e natureza, se dá através de uma educação libertadora e crítica em que o sujeito entende e compreende a conjuntura ambiental que vive. Entende-se que a perspectiva freiriana é capaz de contribuir nas discussões do tema, pois preconiza a formação de sujeitos éticos, preocupados com o que incide no cotidiano da sua rua, bairro, município, estado, país e/ou planeta.
A Tale of Two Cities
Authors: Magistris Francesco Ignazio De 
Published: December 2023

Abstract
Much has been written of the events concerning the Egyptian, Mittanian, and Hittite presence in the northern Levant during the so-called ʿAmārna Period. Decades of work from excellent scholars have established that the Egyptians elected two cities to be their “capitals” in the region, centres from where they could establish their control over the territory of modern Lebanon: Ṣumur on the ʿAkkār Plain, and Kumidi in the Biqāʿ (Beqaa) Valley. Many points remain relatively unclear, such as the succession of events in the region, the developments of war, and the reasons why the Egyptians decided to create a second centre in Kumidi, when they already controlled Ṣumur. This paper reanalyses the data at our disposal and reconstructs the diachronic succession of events related to the two centres, arguing that Kumidi became an Egyptian centre only after Ṣumur had fallen prey to Abdi-Aširta of Amurru.
Teacher–researcher collaborative development of critical (trans)languaging awareness through leveraging linguistic strengths
Authors: Pontier Ryan W. 
Published: December 2023

Abstract
This study explores the collaborative process that two Korean–English and one Spanish–English bilingual Early Head Start family childcare educators, two instructional coaches, and the author engaged in as they co-created intentional bilingual pedagogical approaches to support young emergent bilinguals and co-develop critical (trans)languaging awareness. Data included participant and non-participant observations; field notes; debriefing sessions between the teachers and the author, and instructional coaches and the author; informal interviews with teachers; and two Saturday meet-ups with all participants and the author. Data were analyzed using thematic analysis to identify salient themes in the creation and implementation of practices and pedagogies that leveraged both teachers’ and children’s languaging practices as we deepened our critical language awareness. The design-based collaborative approach that involved co-learning, co-planning, and co-shifting supported our focus on critical language use, trial of different (trans)languaging practices that transgressed English hegemony, and decision-making around how to best leverage everyone’s linguistic strengths in support of children’s developing bilingualism.
The Method Radar: a way to organize methods for technology development with participation in mind
Authors: Schmidt Marc , Bente Stefan , Zanón Bruno Baruque , Lara Palma Ana María 
Published: December 2023

Abstract
Identifying appropriate methods for any process, such as uncovering needs of juveniles in social welfare or designing interactive systems, requires intensive research and generally using a categorization system that brings methods in a systematic order. These taxonomy systems are heavily responsible for the later method usage and start the thinking process for researchers and practitioners alike in a specific direction. So making participation visible in such taxonomy systems directly affects the later method usage and makes participation more visible and easier to use. This article presents the Method Radar, a visualized categorization of methods with a focus on participation using the ladder of participation, that makes participation visible right at the beginning of any method selection. The Method Radar builds on the radar representation established in the technology sector, which allows a multi-dimensional classification. In addition, an implementation and systematic process for categorizing these methods are presented. It can be used for any form of method categorization in which participation is supposed to be thought of.
Crystal structure of 3,3′-(1,4-phenylenebis(methylene))bis(1-isopropyl-1H-imidazol-3-ium) bis(hexafluorophosphate(V)), C10H14F6N2P
Authors: Zou Yi-Chen , Lin Nian-Cheng , Xiong Wan-Ming , Nie Xu-Liang , Wu Su-Qin 
Published: December 2023

Abstract
C10H14F6N2P, orthorhombic, Pbca (no. 61), a = 9.5929(10) Å, b = 15.9201(16) Å, c = 17.8640(19) Å, V = 2728.2(5) Å3, Z = 8, R

gt
(F) = 0.0587, wR

ref
(F
2) = 0.1735, T = 296(2) K.
SLC25 family with energy metabolism and immunity in malignant tumors
Authors: Zhang Guiqian , Wang Ning , Ma Shixun , Wei Zhenhong , Tao Pengxian , Cai Hui 
Published: December 2023

Abstract
Solute Carrier Family 25 (SLC25) is the largest family of mitochondrial membrane proteins in the human body, consisting of 53 members. Mitochondrial phosphate carriers (MPiC), cellular iron metabolism, voltage-dependent anion channels (VDAC), and oxidative phosphorylation in the SLC25 family play dominant roles in material transport, energy metabolism, etc. SLC25 family-related proteins are involved in the regulation of the progression of a variety of cancers, including colon, gastric, and lung cancers. In addition, the SLC25 family has been implicated in endoplasmic reticulum stress (ERS) and immunity. Since SLC25 family proteins are involved in cancer progression and are associated with endoplasmic reticulum stress and immunity, exploring inhibitors of SLC25 family-related proteins is essential. However, the exact mechanism of SLC25 family-related proteins involved in cancer, as well as potential targets and SLC25 inhibitors have not been reported in the literature. This article focuses on summarizing the relevance of the SLC25 family to cancer, ERS, and immunity. This review also provides a comprehensive overview of SLC25 family-related inhibitors.
Conditions for Nynorsk language use – the role of capacity, opportunity, and desire in the maintenance of Nynorsk among Norwegian adolescents
Authors: Sønnesyn Janne 
Published: December 2023

Abstract
This study investigates conditions for language use among Norwegian adolescents using the minoritized Norwegian written language Nynorsk. By combining survey data and focus group interviews, and deploying the framework of ‘capacity’, ‘opportunity’, and ‘desire’ as an analytical lens, the study explores some of the factors and forces that influence the adolescents’ choice to maintain the use of this non-hegemonic Norwegian written language. The paper thus seeks to add to the body of research investigating language maintenance of minoritized languages. The findings illuminate the discrepancy between regulations and practices in the Norwegian language community. Still, even if the collective structures are not optimal, many of the adolescents display a willingness to keep using Nynorsk – a willingness which is partly rendered possible by the existence of these same collective structures. The study thus demonstrates the dialectic relationship between these structures and individual language choices. Moreover, the data show that under given circumstances, some of the same factors and forces that usually further language shift, may also promote language maintenance.
Upcycling of the industrial waste as a sustainable source of axenic fungal strain (Aspergillus oryzae) for scale up enzymatic production with kinetic analysis and Box–Behnken design application
Authors: Iftikhar Tehreema , Majeed Hammad , Altaf Faizah , Khalid Ayesha 
Published: December 2023

Abstract
The utilization of industrial waste for valuable product synthesis is essential for mitigating the environmental impact of climate change and managing waste disposal challenges. Industrial waste is always a big challenge for global warming. In this study, a novel fungus strain was isolated, and identified as Aspergillus oryzae (AKMS), from the oily surface of industrial effluent from an oil industry. Submerged fermentation was exploited to achieve maximum lipases production. A sequence of batch experiments was performed, altering five primary components: sucrose (for carbon), molasses (constituting nutrient mix), yeast extract (as nitrogen supply), sunflower oil (used as an activating agent), and Tween-80 (functioning as an emulsifying agent). These elements are recognized for their substantial impact on the proliferation of microorganisms and, consequently, the synthesis of lipases. The maximum lipase activity for each ingredient was determined, with sucrose showing 2.4 ± 0.539 U/mL at 0.15 g/L, molasses at 1.499 ± 0.291 U/mL at 0.25 g/L, Tween 80 % at 3.33 ± 0.484 U/mL at 0.25 g/L, sunflower oil at 7.49 ± 0.282 U/mL at 1 % v/v, and yeast extract at 4.165 ± 0.841 U/mL at 0.075 % v/v. The optimization of the lipase production and activity was done by using RSM (Box–Behnken design) with the 41st run yielding the maximum activity of 9 U/mL, while the 25th run showed the minimum activity of 4 U/mL, enzyme estimation (U/mL and U/g), glucose (g/L), and dry cell mass estimation (g/L) were monitored up to 120 h of fermentation in a custom-made fermenter with a working volume of 7 L. The highest production of extracellular and intracellular lipases (27.4 ± 0.378 U/mL and 25.4 ± 0.208 U/g, respectively) was observed at the 40 h interval, with the highest value of dry cell mass at 20 g/L. Glucose concentration initially peaked and subsequently decreased over time. A. oryzae exhibited the capability to produce triacyl glycerol acyl hydrolases, demonstrating its potential significance in biotechnological applications. These novel findings shed light on the efficient utilization of oil industry waste soil for isolation of microorganism for sustainable lipase production and highlight the biotechnological promise of the novel isolated fungal strain, which was reported first time in this study.