bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traduction et restes sémantiques. Réflexions autour du mot arabe « taḥlîl » (analyse)
Authors: Ben Rejeb Riadh 
Published: December 2023

Cet article est une invitation à voyager à travers les méandres des langues, des cultures et les labyrinthes de l’inconscient. Il traite de la traduction vers l’arabe de trois mots-clés : psychanalyse, psychanalyser et psychanalyste. Les équivalents arabes de ces trois mots dérivent de la même racine « Ḥa-La-La ». L’analyse se dit en arabe « taḥlîl », analyser se dit « ḥallala » et l’analyste est appelé « muḥallil ». Se cache en filigrane un lien avec la dichotomie morale musulmane : « ḥalâl » / « ḥarâm » désignant le permis et le non permis, le licite et l’illicite. Ces aspects sémantiques oubliés (ou refoulés) invitent à revoir le sens du travail analytique ainsi que le rôle particulier joué par l’analyste dans l’environnement culturel arabo-musulman. La psychanalyse véhiculerait dans ce contexte une dimension particulière, celle de « rendre ḥalâl », c’est-à-dire de nettoyer, d’épurer et pourquoi pas, celle d’autoriser.
James et Husserl : Perception des formes et polarisation des flux de conscience
Authors: Leclerq B. , Galetic S. 
Published: December 2023

Les notes prises par Husserl dans son exemplaire personnel des Principles of Psychology attestent de l’intérêt qu’il porta aux travaux psychologiques de William Jameset singulièrement aux développements du chapitre XX consacré à la perception de l’espace. Le propos du présent article est double : éclairer dans le détail les raisons de l’importance que Husserl accorde au traitement jamesien de la perception spatiale pour définir sa conception de l’expérience ; souligner le rôle pivot que joue cette problématique dans l’architecture de l’œuvre de William James lui-même, au regard notamment de cette théorie ambulatoire de la connaissance qui constitue le socle de son empirisme radical et de son pragmatisme.
Alasdair MacIntyre en France
Authors: Descombes Vincent 
Published: December 2023

En France, l’œuvre d’Alasdair MacIntyre a été l’objet de lectures politiques contrastées. Pour les uns, l’auteur, trop influencé par Wittgenstein, ne parvient pas à donner une portée politique à sa critique de l’individualisme libéral. Pour d’autres, à l’inverse, MacIntyre, trop aristotélicien, tire Wittgenstein dans le camp conservateur. MacIntyre a-t-il une philosophie politique ? En fait, la question que pose MacIntyre à la fin d’ Après la vertu est profondément politique, puisqu’il s’agit de savoir où mène la critique du marxisme. A cet égard, le retour à Aristote que préconise MacIntyre – un retour qui maintient le sens politique de l’éthique – peut être rapproché de celui qu’opère Castoriadis à la même époque.
Uterine Manipulation May Not Influence Ongoing Pregnancy: Case Report and Literature Review
Authors: Wan* Kaijing , Hameed Mohamed Siraj Shahul , Wright Ann , Chern Bernard Su Min 
Published: December 2023

Abstract
Abdominal pain is a very common presentation in early pregnancy. Its cause may be gynecological or totally nonpregnancy related. While acute appendicitis is the most common nonobstetric cause of pain in pregnant women, diagnosis and differentiation from other causes, including ectopic pregnancy, remain challenging. In clinical situations of uncertainty, laparoscopy is a useful diagnostic tool, but uterine manipulation should be avoided if an intrauterine pregnancy is a possibility. In this report, we describe a case of complicated appendicitis in very early pregnancy where the patient ended with a full-term healthy pregnancy despite undergoing a diagnostic laparoscopy with inadvertent uterine manipulation.
Survival analysis of ovarian cancer patients with distant metastasis after chemotherapy: A SEER-based study
Authors: Cheng Lifang , Zhang Jian 
Published: December 2023

Abstract

Background:
This study investigated the overall survival (OS) of patients with distant metastasis of ovarian cancer after chemotherapy and surgery, and explored differences in the survival of these patients with single-site metastasis.

Methods:
We selected only patients with stage IV ovarian cancer who had undergone chemotherapy. Using GraphPad Prism 7 software and Kaplan-Meier survival analysis, we confirmed the factors that were meaningful for OS. Survival-related risk factors were compared using the Cox proportional hazards model.

Results:
Patients with lung, bone, and brain metastasis experienced shorter survival than patients with liver metastasis who underwent chemotherapy. Among patients with distant metastasis who underwent chemotherapy and surgery, patients with brain metastasis experienced longer survival than patients with liver metastasis, while patients with bone and lung metastasis presented shorter survival than patients with liver metastasis. Finally, surgery prolonged the survival of patients with stage IV ovarian cancer with single-site metastasis, who were treated with chemotherapy.

Conclusions:
Chemotherapy combined with surgery significantly prolonged OS and cancer-specific survival (CSS) of patients with distant metastatic stage IV ovarian cancer. Lung metastasis resulted in a shorter survival than liver metastasis in patients treated with chemotherapy alone or in combination with surgery.
Effectiveness of tobacco counseling training module (TCTM) in enhancing the knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling among undergraduate dental students – An interventional study
Authors: Chandrashekar Byalakere R. , Chacko Thomas V. , Jayashankar HP , Suma S , Anand KM , Kannappan Suvetha 
Published: December 2023

Background:
Tobacco use has emerged as a major public health issue with increasing tobacco-related morbidity and mortality. Despite evidence that even brief tobacco counseling by health care professionals is effective in motivating a tobacco user to quit, there was a lack of customized tobacco counseling training module (TCTM) for students of dentistry in their existing curriculum. This study was undertaken to evaluate the effectiveness of a customized TCTM in improving KAASS in tobacco counseling among undergraduate dental students.

Methods:
TCTM that was previously pilot tested was implemented as a value addition in Public Health Dentistry for two academic years. Changes in knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling were assessed before and after implementation of TCTM. Mean pre and post intervention scores were compared.

Results:
Mean scores for knowledge, attitude, ability to identify oral manifestations, and self-confidence (KAAS) at baseline were 4.4 ± 0.9, 5.1 ± 0.7, 4.5 ± 1.1, and 1.3 ± 0.4, respectively. Mean KAAS scores post intervention were 13.5 ± 1.0, 8.7 ± 0.4, 9.4 ± 0.7, and 3.5 ± 0.5, respectively. There was a significant improvement in the mean KAAS score post intervention compared to baseline. Tobacco counseling skills also significantly improved among the participants following implementation of the training module (68.8%) did well compared to the baseline (0%).

Conclusion:
TCTM was effective in enhancing knowledge, attitude, ability to identify oral manifestations, and self-confidence in tobacco counseling among undergraduate dental students.
Bevacizumab-containing regimens for children with relapsed or refractory tumors
Authors: Yağcı-Küpeli Begül , Pehlivan Duygu 
Published: December 2023

Background:
We aimed to evaluate the effect of bevacizumab-containing regimens (BCRs) on the survival of children with relapsed or refractory solid tumors.

Materials and Methods:
Files of children with relapsed or refractory solid tumors treated with BCR were retrospectively reviewed for age, gender, follow-up time, histopathological diagnosis, adverse events observed with BCR, number of chemotherapy protocols used before BCR, the best overall response obtained with BCR, time to progression, number of BCR courses given to patients, the status of patient at last visit, and outcome.

Results:
Thirty patients (16 boys, 14 girls) were treated with BCR. The median age at diagnosis was 8.5 (2 - 17) years and at the time of the study was 11 (3-21) years. The median follow-up time was 25.7 (5-79.4) months. The median follow-up time after the start of BCR was 3.2 (1-27) months. Histopathological diagnosis was central nervous system tumors in 25, Ewing sarcoma in two, osteosarcoma in two, and rhabdomyosarcoma in one patient. BCR was given as second-line in 21, third-line in six, and fourth-line protocol in three patients. No chemotherapy toxicity was observed in 22 (73.3%) patients. The best overall response was progressive disease in 17 (56.7%), partial response in seven (23.3%), and stable disease in 6 (20%) patients at first-response evaluation. The median time until progression was 77 (12-690) days. During the study period, 17 patients died of progressive disease.

Conclusion:
Our study revealed that adding antiangiogenic agent bevacizumab to cytotoxic chemotherapy provided no survival benefit in children with relapsed or refractory solid tumors.
Nano silver fluoride versus silver diamine fluoride with potassium iodide on carious dentine of primary teeth
Authors: Ghareep Sara Mohamed Ezz Eldeen , Elhendawy Fatma Abd Almoniem , Khatab Arafa Mohamed , Amer Wessam Hatem Saad 
Published: December 2023

Background
Dental caries is one of the most prevalent diseases, and treating carious lesions remains a major concern, especially in pediatric dentistry. Minimally invasive interventions have been proposed as a promising treatment modality for caries control.

Aim
This study evaluated nano silver fluoride versus silver diamine fluoride with potassium iodide for the treatment of carious dentine in primary teeth.

Material and methods
This in vivo study was performed on 30 children presented with 60 primary molars with soft dentinal lesions. Carious teeth were assigned into two equal groups: group I received silver diamine fluoride with potassium iodide, while group II received nano silver fluoride. Teeth were diagnosed and treated at the baseline visit and followed up for clinical evaluation at 3, 6, and 9 months. Also, dentine samples were obtained from the initial carious teeth and after 9 months of applying the treatments for microbiological evaluation.

Results
Both groups had comparable clinical values at 3, 6, and 9 months, with no statistically significant difference. While after 9 months, there was a highly significant increase in the number of teeth showing dentine color change in group I compared with group II. Microbiological results showed no significant difference in the reduction of Lactobacillus count between both groups. While there was a significant difference between both groups in terms of Streptococcus mutans count.

Conclusion
Silver diamine fluoride with potassium iodide and nano silver fluoride provides simple and effective dentinal caries management.
Three-dimensional customized titanium plate versus conventional titanium miniplate for management of mandibular angle fractures
Authors: Hashish Ahmed Sobhy Ibrahim Abou , Khedr Mohamed M. Saad , Nowair Ibrahim M. , Eid Mohamed K. 
Published: December 2023

Background
Surgical treatment of mandibular angle fractures using an internal fixation has changed in the last decades to achieve the required rigidity, stability, and immediate restoration of function.

Purpose
The aim of the study was to evaluate both clinically and radiologically the efficacy of three-dimensional customized titanium plate versus conventional titanium miniplate in the management of mandibular angle fractures.

Patients and methods
Sixteen adult patients with unilateral mandibular angle fracture indicated for reduction and internal fixation were selected from the Outpatient Clinic, Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Tanta University. Patients were divided into two equal groups according to the type of plating system used in fracture fixation, for group I mandibular angle fractures were fixed with 3-D customized titanium plate while for group II mandibular angle fractures were fixed with single conventional titanium miniplate. Postoperative clinical and radiographic evaluations were performed immediately, one week, two weeks, one month, three months and six months. The postoperative clinical evaluation included presence or absence of infection, position and stability of the mandibular lower border, state of occlusion, maximal mouth opening, sensory nerve function, condition of teeth related to the fracture line and patient's tolerance to the plate. The postoperative radiographic examinations evaluated the accuracy of reduction and bony union by measuring the inter-fragmentary gap and the intergonial distance.

Results
Uneventful wound healing was obtained in all cases of both groups except case no 4 of group II in which dehiscence and mild infection was happened. Satisfactory occlusion was obtained in all cases of both groups except case no 7 of group II where it had mild occlusal derangement. Other parameters including clinical stability, maximal mouth opening, sensory nerve function, and plate tolerance were comparable in both groups. There were no significant differences between group I and group II regarding inter-fragmentary gap and intergonial distance regarding postoperative radiographs.

Conclusion
The use of three-dimensional customized titanium plate and conventional titanium miniplate fixation systems provided enough stability for proper bone healing, establishment of optimal occlusion, and early return to normal function.
Effect of ultrasound-guided lumbar square muscle block on stress response in patients undergoing radical gastric cancer surgery
Authors: Wang Xin-Ran , Xu Dan-Dan , Guo Meng-Jiao , Wang Yi-Xin , Zhang Meng , Zhu Dong-Xiao 
Published: December 2023

BACKGROUND
Radical surgery is a common treatment for patients with gastric cancer; however, it can lead to postoperative complications and intestinal barrier dysfunction. Ultrasound-guided quadratus lumborum block is often used for postoperative analgesia, but its effects on stress response and intestinal barrier function are not well understood.
AIM
To investigate the effects of an ultrasound-guided quadratus lumborum block on stress response and intestinal barrier function in patients undergoing radical surgery for gastric cancer.
METHODS
A total of 100 patients undergoing radical surgery for gastric cancer were randomly categorized into observation and control groups. Plasma adrenaline and cortisol levels, intestinal mucosal barrier indexes, and complication rates were compared between the two groups before, during, and 1 day after surgery.
RESULTS
The observation group had significantly lower plasma adrenaline and cortisol levels during surgery and at 1 day postoperatively than that of the control group (P < 0.05). Additionally, intestinal barrier indexes (endotoxin and D-dimer) at 1 day postoperatively were significantly lower in the observation group than in the control group (P < 0.05).
CONCLUSION
Ultrasound-guided quadratus lumborum block could reduce stress response, protect intestinal barrier function, and decrease the incidence of complications in patients undergoing radical surgery for gastric cancer. This technique has the potential for clinical applications.
Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study
Authors: Zhang Wen-Jing , Yue Ke-Lin , Wang Jing-Zhai , Zhang Yu 
Published: December 2023

BACKGROUND
We previously demonstrated that heat shock factor protein 4 (HSF4) facilitates colorectal cancer (CRC) progression. DNA methylation, a major modifier of gene expression and stability, is involved in CRC development and outcome.
AIM
To investigate the correlation between HSF4 methylation and CRC risk, and to uncover the underlying molecular mechanisms.
METHODS
Differences in β values of HSF4 methylation loci in multiple malignancies and their correlation with HSF4 mRNA expression were analyzed based on Shiny Methylation Analysis Resource Tool. HSF4 methylation-related genes were identified by LinkedOmics in CRC, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed. Protein-protein interaction network of HSF4 methylation-related genes was constructed by String database and MCODE algorithm.
RESULTS
A total of 19 CpG methylation loci were identified in HSF4 , and their β values were significantly increased in CRC tissues and exhibited a positive correlation with HSF4 mRNA expression. Unfortunately, the prognostic and diagnostic performance of these CpG loci in CRC patients was mediocre. In CRC, there were 1694 HSF4 methylation-related genes; 1468 of which displayed positive and 226 negative associations, and they were involved in regulating phenotypes such as immune, inflammatory, and metabolic reprogramming. EGFR , RELA , STAT3 , FCGR3A , POLR2K , and AXIN1 are hub genes among the HSF4 methylation-related genes.
CONCLUSION
HSF4 is highly methylated in CRC, but there is no significant correlation between it and the prognosis and diagnosis of CRC. HSF4 methylation may serve as one of the ways in which HSF4 mediates the CRC process.
Association of MBOAT7 rs641738 polymorphism with hepatocellular carcinoma susceptibility: A systematic review and meta-analysis
Authors: Lai Min , Qin Ya-Lu , Jin Qiong-Yu , Chen Wen-Jing , Hu Jia 
Published: December 2023

BACKGROUND
The MBOAT7 rs641738 single-nucleotide polymorphism (SNP) has been proven to influence various liver diseases, but its association with hepatocellular carcinoma (HCC) susceptibility has been debated. To address this discrepancy, we conducted the current systematic review and meta-analysis.
AIM
To perform a systematic review and meta-analysis on association of MBOAT7 SNP and HCC susceptibility.
METHODS
We performed a systematic review in PubMed, Web of Science, Scopus, and EMBASE; applied specific inclusion and exclusion criteria; and extracted the data. Meta-analysis was conducted with the meta package in R. Sensitivity and subgroup analyses were also performed. This meta-analysis was registered in PROSPERO (CRD42023458046).
RESULTS
Eight studies were included in the systematic review, and 12 cohorts from 6 studies were included in the meta-analysis. Our meta-analysis revealed an association between the MBOAT7 SNP and HCC susceptibility in both the dominant [odds ratio (OR): 1.14, 95% confidence interval (95%CI): 1.02-1.26, P = 0.020] and recessive (OR: 1.21, 95%CI: 1.05-1.39, P = 0.008) models. Subgroup analysis revealed that stratification of the included patients by geographical origin showed a significant association in Asia (OR: 1.20, 95%CI: 1.03-1.39).
CONCLUSION
This meta-analysis underscores the contribution of the MBOAT7 rs641738 SNP to hepatocarcinogenesis, especially in Asian populations, which warrants further investigation.
Impact of Opt-Out Therapy Appointments on Resident Physicians’ Mental Health, Well-Being, Stigma, and Willingness to Engage
Authors: Kevern Taylor , Davies D. Rob , Stiel Katie , Raaum Sonja 
Published: December 2023

Background Health care professionals report higher levels of mental health symptoms, pandemic-related stress, personal health concerns, and reduced proactive coping, especially in recent years marked by the COVID-19 pandemic. As physician utilization rates of mental health and well-being services remain low, the need for preemptive care is crucial.
Objective The present study sought to ascertain satisfaction, value, and attitude toward future mental health services among resident physicians.
Methods Throughout the 2020-2021 academic year, resident physicians within 8 training programs at a large academic training hospital were offered single opt-out mental health appointments from hospital-funded, graduate medical education wellness staff at no cost to the resident. Appointments were conducted virtually during protected work time. A survey was sent to participants within 2 weeks following their appointment.
Results A total of 153 residents (postgraduate years 1 to 7) were offered one-time opt-out appointments. Overall, 91 (59%) residents attended their opt-out appointments. Survey response rate was 57% (n=52). Respondents reported high levels of satisfaction (96%, 50 of 52), felt the appointment was worth their time (96%, 50 of 52), and felt that the opt-out appointments demonstrated training programs cared about their well-being (94%, 49 of 52). Nearly all residents (98%, 51 of 52) recommended appointments be offered to future residents. Most respondents (80%, 42 of 52) indicated that appointments increased their willingness to engage in mental health services.
Conclusions Opt-out appointments increased resident willingness to engage in mental health services, positive attitudes toward future mental health services, perceived training program’s care about their well-being, and reduced perceived mental illness stigma.
Implementation of a Quality Metrics Competition to Improve Panel Management Among Internal Medicine Residents
Authors: Deffendall Catherine , Lopez Christine , Trumbo Silas P. , Garrard Aelinor , Jones Jill , Peterson Neeraja B. 
Published: December 2023

Background Panel management is essential for residents to learn, yet challenging to teach. To our knowledge, prior literature has not described curricula utilizing a financially incentivized competition to improve resident primary care metrics.
Objective We developed a panel management curriculum, including a financially incentivized quality competition, to improve resident performance on quality metrics.
Methods We developed a cancer screening and diabetes metric quality competition for internal medicine residents at Vanderbilt University Medical Center for their primary care clinics for the 2020-2021 (pilot) and 2021-2022 academic years. Residents received several educational tools, including a 1-hour introduction to the health maintenance dashboard within the electronic medical record (EMR) and instructions on how to access the quality dashboard outside the EMR, and were encouraged to discuss panel management with preceptors. Chief residents distributed measures to trainees 3 times annually, so residents were aware of their competition ranking. Residents’ composite metrics at year end were compared to baseline to determine top performers. The top 15 performers received $100 gift cards as incentives. We also assessed the curriculum’s impact on the residents’ metrics in aggregate.
Results At curriculum completion, residents (n=100) demonstrated an average improvement of 1.9% from baseline composite metrics for the percent of patients receiving screening. In aggregate, residents improved in every measure except HbA1c testing. Breast cancer screening had the largest improvement from 69.5% (1518 of 2183) to 75.6% (1646 of 2178) of all patients receiving recommended screening.
Conclusions The curriculum resulted in more patients receiving recommended cancer and diabetes screenings.