bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of historic sediment characterisation on predicting polychaete distributions: a case study of so-called muddy habitat shovelhead worms (Annelida: Magelonidae)
Authors: Mills Kimberley , Mortimer Kate 
Published: November 2023

Abstract
Shovelhead worms are common polychaetes around the British Isles and have been recorded in numerous ecological surveys. Yet, understanding of their habitat conditions is poor, based heavily on visual observations of sediments from historical records. In this study, the drivers of abundance and geographical distribution of two morphologically and behaviourally diverse species Magelona alleni and Magelona minuta are investigated by reanalysing sediment characteristics and depths from museum marine monitoring surveys. Although both species are historically associated with muddy sediments, the records herein suggest that M. alleni occurs in an extensive range of sediments, but is more abundant at localities with more than 25% sand. In comparison, M. minuta shows a negative linear relationship between grain diameter and abundance, corroborating previous work that the species is abundant in fine-grained mud. The depth records show that while M. alleni predominates below 60 m, M. minuta is a distinct offshore species. These differences may be attributed to the interspecific variation in morphology and motility between the species: M. alleni is stout and tube-dwelling, while M. minuta is fragile, small, and fairly motile. To corroborate these findings, sediment grains from tubes of M. alleni were classified using the Udden–Wentworth grain size scale and suggest sand is the key component for tube construction. Overall, this study highlights that sediment parameters for M. alleni have been misinterpreted and generalised in historical records, emphasising the importance of quantitative sediment analysis in defining the habitat of Magelona.
Songs materialising as music: medieval monophony in song books and music manuscripts
Authors: HUCK OLIVER 
Published: November 2023

ABSTRACTThis survey of the mise-en-page of manuscripts that include medieval monophonic song focuses on complex multigraphic written artefacts presenting music on staves. Comparing the formatting of thirteenth-century French chansonniers and fifteenth-century collections of monophonic songs (BnF fr. 9346 and BnF fr. 12744), there are obvious differences in the mise-en-page. But when, where and why did the changes in the production of manuscripts and the materialisation of songs take place? This article proposes a distinction between entirely pre-ruled ‘“full” music manuscripts’, ‘music manuscripts’ employing pre-ruling and ‘manuscripts with music’ where the staves were drawn only after the text has been written. Moreover, ‘songbooks’ mainly interested in lyrics can be distinguished from ‘song books’ focusing on the music. The interrelation of production process, content and manuscript type is discussed using the example of the conductus In hoc ortus occidente. The emergence, interrelation and particularities of layouts are discussed for vernacular thirteenth- or fourteenth-century songbooks with Dutch, English/Anglo-Norman, French, Galego-Portuguese, German, Italian and Occitan texts. The two-column layout is found in songbooks all over Europe (except for Italian laudari). This article examines models such as rolls, libelli, Dominican liturgical books, particularities of layouts such as different strophic page layouts and as the separation of verses in some troubadour chansonniers and Galego-Portuguese cancionieros as well as the dissemination in German speaking regions through minstrel schools. Comparing French, German and Italian song books of monophonic song as well lais/Leich and/or polyphony reveals differences in the production process of Italian ‘“full” music manuscripts’ (BAV Rossi 215/I-OST, I-REas and I-Fl Mediceo Palatino 87), German ‘music manuscripts’ (A-Wn 2701, A-Wn 2777 and CZ-Pu XI E 9) and French ‘manuscripts with music’ (BnF fr. 146 and the Machaut-collections).
The responsories of the Old Hispanic Night Office and their sources
Authors: RANDEL DON MICHAEL 
Published: November 2023

ABSTRACTDespite their paucity, the surviving sources for the Old Hispanic Rite make possible the identification of the earliest kernel of responsories for the Night Office. They show how this first group of responsories, assigned to the Ferial Office, was subsequently distributed over the Sundays of Lent. Comparison of the notation for these responsories, both refrains and verses, across the several sources enables a more solid geographical grouping of the manuscripts than do the palaeographical studies of the verbal texts that have hitherto prevailed.
Development and Validation of a New Tool to Improve the Accuracy of the Hospital Mass-Casualty Incident Response Plan Activation: The PEMAAF Score
Authors: Ruffini Claudia , Trentin Monica , Corona Alberto , Caviglia Marta , Sechi Giuseppe Maria , Migliari Maurizio , Stucchi Riccardo , Ragazzoni Luca , Fumagalli Roberto 
Published: November 2023

AbstractIntroduction:Effective response to a mass-casualty incident (MCI) entails the activation of hospital MCI plans. Unfortunately, there are no tools available in the literature to support hospital responders in predicting the proper level of MCI plan activation. This manuscript describes the scientific-based approach used to develop, test, and validate the PEMAAF score (Proximity, Event, Multitude, Overcrowding, Temporary Ward Reduction Capacity, Time Shift Slot [Prossimità, Evento, Moltitudine, Affollamento, Accorpamento, Fascia Oraria], a tool able to predict the required level of hospital MCI plan activation and to facilitate a coordinated activation of a multi-hospital network.Methods:Three study phases were performed within the Metropolitan City of Milan, Italy: (1) retrospective analysis of past MCI after action reports (AARs); (2) PEMAAF score development; and (3) PEMAAF score validation. The validation phase entailed a multi-step process including two retrospective analyses of past MCIs using the score, a focus group discussion (FGD), and a prospective simulation-based study. Sensitivity and specificity of the score were analyzed using a regression model, Spearman’s Rho test, and receiver operating characteristic/ROC analysis curves.Results:Results of the retrospective analysis and FGD were used to refine the PEMAAF score, which included six items–Proximity, Event, Multitude, Emergency Department (ED) Overcrowding, Temporary Ward Reduction Capacity, and Time Shift Slot–allowing for the identification of three priority levels (score of 5-6: green alert; score of 7-9: yellow alert; and score of 10-12: red alert). When prospectively analyzed, the PEMAAF score determined most frequent hospital MCI plan activation (>10) during night and holiday shifts, with a score of 11 being associated with a higher sensitivity system and a score of 12 with higher specificity.Conclusions:The PEMAAF score allowed for a balanced and adequately distributed response in case of MCI, prompting hospital MCI plan activation according to real needs, taking into consideration the whole hospital response network.
Wenn es zu bunt wird, gehe ich wieder
Authors: Rüegg Sebastian 
Published: November 2023

Was ist zu diesem Thema bereits bekannt? Im Gegensatz zu der von Patient_innen ausgehenden Aggression und Gewalt gegenüber Fachpersonen, stellen die Gewaltanteile psychiatrischer Pflege ein Tabuthema dar. Wie wird eine neue Perspektive eingebracht? Im Artikel wird die Thematik mit Fokus auf die Sichtweise von Berufseinsteiger_innen und Studierenden aus dem letzten Ausbildungsjahr dargestellt. Was sind die Auswirkungen für die Praxis? Gewaltanteile Psychiatrischer Pflege können für Berufseinsteiger_innen und Studierende eine berufliche Sozialisation Widerwillen und eine hohe Unzufriedenheit mit der Berufsausübung mit sich bringen. Fehlende Reflexionsmöglichkeiten und die Tabuisierung der verschiedenen Gewaltanteile verstärken die Problematik zusätzlich.
Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis
Authors: Lambrecht Rebekka , Rudolf Franziska , Ückert Anna-Katharina , Sladky Valentina C. , Phan Truong San , Jansen Jasmin , Naim Samara , Kaufmann Thomas , Keogh Adrian , Kirschnek Susanne , Mangerich Aswin , Stengel Florian , Leist Marcel , Villunger Andreas , Brunner Thomas 
Published: November 2023

AbstractParacetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality. Here, we studied this switch of cell death modes and demonstrate a non-canonical role of the apoptosis-regulating BCL-2 homolog BIM/Bcl2l11 in promoting necrosis by regulating cellular bioenergetics. BIM deficiency enhanced total ATP production and shifted the bioenergetic profile towards glycolysis, resulting in persistent protection from APAP-induced liver injury. Modulation of glucose levels and deletion of Mitofusins confirmed that severe APAP toxicity occurs only in cells dependent on oxidative phosphorylation. Glycolytic hepatocytes maintained elevated ATP levels and reduced ROS, which enabled lysosomal recycling of damaged mitochondria by mitophagy. The present study highlights how metabolism and bioenergetics affect drug-induced liver toxicity, and identifies BIM as important regulator of glycolysis, mitochondrial respiration, and oxidative stress signaling.
Genetic evidence for causal effects of leukocyte counts on risk for rheumatoid arthritis
Authors: You Jin-Mei , Zhang Yao-Chen , Fan Ke-Yi , Bai Shang-Kai , Zhang Zi-Yu , Zhang He-Yi , Cheng Ting , Huo Yue-Hong , Wang Cai-Hong , Li Xiao-Feng , Zhang Sheng-Xiao 
Published: November 2023

AbstractRheumatoid arthritis (RA) is an autoimmune disease characterized by the accumulation of leukocytes and inflammatory mediators within the synovial tissue. Leukocyte counts are proposed to play a role in the pathogenesis of RA. However, the causality remains unclear. To investigate the causal relationship between various leukocytes and RA by implementing two-sample univariable Mendelian Randomization (MR) and multivariable MR. MR analysis was performed using respective genome-wide association study (GWAS) summary statistics for the exposure traits (eosinophil counts, neutrophil counts, lymphocyte counts, monocyte counts, basophil counts, and white blood cell counts) and outcome trait (RA). Summary statistics for leukocytes were extracted from the Blood Cell Consortium meta-analysis and INTERVAL studies. Public GWAS information for RA included 14,361 cases and 43,923 controls. Inverse variance weighted, weighted median, MR-Egger regression, MR pleiotropy residual sum and outlier, and multivariable MR analyses were performed in MR analysis. Univariable MR found elevated eosinophil counts (OR 1.580, 95% CI 1.389–2.681, p = 1.30 × 10–7) significantly increased the risk of RA. Multivariable MR further confirmed that eosinophil counts were a risk factor for RA. Increased eosinophils were associated with higher risk of RA. Further elucidations of the causality and mechanisms underlying are likely to identify feasible interventions to promote RA prevention.
A population-based study on incidence trends of myeloma in the United States over 2000–2020
Authors: Mousavi Seyed Ehsan , Ilaghi Mehran , Aslani Armin , Yekta Zahra , Nejadghaderi Seyed Aria 
Published: November 2023

AbstractMyeloma is one of the most common types of haematological malignancies. We aimed to investigate the incidence rates of myeloma by sex, race, age, and histological subgroups in the United States (US) over 2000–2020. Data were retrieved from the the Surveillance, Epidemiology, and End Results (SEER) 22 database. The International Classification of Diseases for Oncology version 3 morphological codes 9731, 9732, and 9734 were assigned for solitary plasmacytoma of bone, plasma cell myeloma, and extraosseous plasmacytoma, respectively. Average annual percent change (AAPC) and the pairwise comparison with the parallelism and coincidence were reported. All estimates were reported as counts and age-adjusted incidence rates per 100,000 individuals. Over 2000–2019, most of myeloma cases were among those aged at least 55 years (85.51%), men (54.82%), and non-Hispanic Whites (66.67%). Among different subtypes, plasma cell myeloma with 193,530 cases had the highest frequency over the same period. Also, there was a significant decrease in the age-standardized incidence rate of myeloma across all races/ethnicities in both sexes within all age groups (AAPC: − 8.02; 95% confidence interval (CI): − 10.43 to − 5.61) and those aged < 55 (AAPC: − 8.64; 95% CI − 11.02 to − 6.25) from 2019 to November 2020. The overall trends of myeloma incidence rates were not parallel, nor identical. There was an increase in myeloma incidence in both sexes, with a highly increasing rate, particularly among younger Hispanic and non-Hispanic Black women over 2000–2019. However, a remarkable decline was observed in the incidence rates following the COVID-19 pandemic in 2020.
Influence of Breed and Body Conformation on Vertebral Implant Insert Angles in Dogs
Authors: Nowak Lina , Grapes N. , De Decker S. 
Published: November 2023

Abstract
Objective To evaluate the effect of breed and body conformation on the vertebral insertion corridor angles for stabilizing spinal surgery in dogs.
Study Design Computed tomography studies of the vertebral column of 100 dogs from 10 representatives of 10 FCI (Fédération Cynologique Internationale) breed groups were randomly and blindly evaluated for vertebral insertion corridor angles. Insertion angles were measured for the last six cervical vertebrae (C2–C7), the last four thoracic vertebrae (T10–T13), the seven lumbar vertebrae (L1–L7), and the sacrum (S1).
Results Insertion angle was significantly influenced by breed at C6 (p = 0.001), C7 (p = 0.008), T13 (p = 0.032), L6 (p = 0.011), and S1 (p = 0.009). At C6, Pugs had significantly larger mean insertion angles (MIAs) compared with Beagles (p = 0.016), Miniature Dachshunds (p = 0.024), Greyhounds (p = 0.004), and West Highland White Terriers (p = 0.001). English Springer Spaniels had significantly smaller MIA at C7 compared with Siberian Huskies (p = 0.037) and Pugs (p = 0.033). German Shepherds had significantly smaller MIA at L6 compared with Beagles (p = 0.044), Miniature Schnauzers (p = 0.029), and English Springer Spaniels (p = 0.047). Miniature Dachshunds had significantly larger MIA at S1 compared with Beagles (p = 0.009), Pugs (p = 0.015), Miniature Schnauzers (p = 0.010), and English Springer Spaniels (p = 0.006).
Conclusion Breed and body conformation are important factors when planning instrumented spinal surgery in dogs. Individualized planning for spinal instrumentation seems to be critical.
Lymphatic venous anastomosis and complex decongestive therapy for lymphoedema: randomized clinical trial
Authors: Mihara Makoto , Hara Hisako , Kawasaki Yohei , Mitsuhashi Toshiharu , Orikasa Hideki , Ando Hirohiko , Naito Munekazu 
Published: November 2023

Abstract

Background
Lymphatic venous anastomosis is associated with a low incidence of lower extremity lymphoedema-associated cellulitis; however, the exact relationship is unknown. This multicentre RCT evaluated the effect of lymphatic venous anastomosis on prevention of cellulitis.

Methods
Patients with secondary lower extremity lymphoedema who underwent at least 3 months of non-operative decongestive therapy were assigned randomly to lymphatic venous anastomosis or conservative therapy. The primary and secondary outcomes were cellulitis frequency, and assessments of circumference, hardness, and pain respectively.

Results
Overall, 336 patients were divided into two groups: 225 in the full-analysis set (primary outcome 225; secondary outcomes 170) and 156 in the per-protocol set (primary outcome 156; secondary outcomes 110). In both analyses, lymphatic venous anastomosis with non-operative decongestive therapy was more effective in preventing cellulitis than non-operative decongestive therapy alone; the difference between groups in reducing cellulitis frequency over 6 months was −0.35 (95 per cent c.i. −0.62 to −0.09; P = 0.010) in the full-analysis set (FAS) and −0.60 (−0.94 to −0.27; P = 0.001) in the per-protocol set (PPS) Limb circumference and pain were not significantly different, but lymphatic venous anastomosis reduced thigh area hardness (proximal medial and distal and lateral proximal). Four patients experienced contact dermatitis with non-operative decongestive therapy alone.

Conclusion
Lymphatic venous anastomosis in combination with non-operative decongestive therapy prevents cellulitis.

Registration number
UMIN00025137, UMIN00031462.
Differential involvement of mitochondria in post-tetanic potentiation at intracortical excitatory synapses of the medial prefrontal cortex
Authors: Lee Hyoung-Ro , Choi Sung Hoon , Lee Suk-Ho 
Published: November 2023

Abstract
Post-tetanic Ca2+ release from mitochondria produces presynaptic residual calcium, which contributes to post-tetanic potentiation. The loss of mitochondria-dependent post-tetanic potentiation is one of the earliest signs of Alzheimer’s model mice. Post-tetanic potentiation at intracortical synapses of medial prefrontal cortex has been implicated in working memory. Although mitochondrial contribution to post-tetanic potentiation differs depending on synapse types, it is unknown which synapse types express mitochondria-dependent post-tetanic potentiation in the medial prefrontal cortex. We studied expression of mitochondria-dependent post-tetanic potentiation at different intracortical synapses of the rat medial prefrontal cortex. Post-tetanic potentiation occurred only at intracortical synapses onto layer 5 corticopontine cells from commissural cells and L2/3 pyramidal neurons. Among post-tetanic potentiation-expressing synapses, L2/3-corticopontine synapses in the prelimbic cortex were unique in that post-tetanic potentiation depends on mitochondria because post-tetanic potentiation at corresponding synapse types in other cortical areas was independent of mitochondria. Supporting mitochondria-dependent post-tetanic potentiation at L2/3-to-corticopontine synapses, mitochondria-dependent residual calcium at the axon terminals of L2/3 pyramidal neurons was significantly larger than that at commissural and corticopontine cells. Moreover, post-tetanic potentiation at L2/3-corticopontine synapses, but not at commissural-corticopontine synapses, was impaired in the young adult Alzheimer’s model mice. These results would provide a knowledge base for comprehending synaptic mechanisms that underlies the initial clinical signs of neurodegenerative disorders.
Detecting a disc bending wave in a barred-spiral galaxy at redshift 4.4
Authors: Tsukui Takafumi , Wisnioski Emily , Bland-Hawthorn Joss , Mai Yifan , Iguchi Satoru , Baba Junichi , Freeman Ken 
Published: November 2023

ABSTRACT
The recent discovery of barred spiral galaxies in the early Universe (z &gt; 2) poses questions of how these structures form and how they influence galaxy evolution in the early Universe. In this study, we investigate the morphology and kinematics of the far-infrared (FIR) continuum and [C ii] emission in BRI1335-0417 at z ≈ 4.4 from ALMA observations. The variations in position angle and ellipticity of the isophotes show the characteristic signature of a barred galaxy. The bar, $3.3^{+0.2}_{-0.2}$ kpc long in radius and bridging the previously identified two-armed spiral, is evident in both [C ii] and FIR images, driving the galaxy’s rapid evolution by channelling gas towards the nucleus. Fourier analysis of the [C ii] velocity field reveals an unambiguous kinematic m = 2 mode with a line-of-sight velocity amplitude of up to ∼30–40 km s−1; a plausible explanation is the disc’s vertical bending mode triggered by external perturbation, which presumably induced the high star formation rate and the bar/spiral structure. The bar identified in [C ii] and FIR images of the gas-rich disc galaxy (≳ 70 per cent of the total mass within radius R ≈ 2.2 disc scale lengths) suggests a new perspective of early bar formation in high redshift gas-rich galaxies – a gravitationally unstable gas-rich disc creating a star-forming gaseous bar, rather than a stellar bar emerging from a pre-existing stellar disc. This may explain the prevalent bar-like structures seen in FIR images of high-redshift submillimeter galaxies.
Probing cosmic isotropy in the Local Universe
Authors: Franco Camila , Avila Felipe , Bernui Armando 
Published: November 2023

ABSTRACT
This is a model-independent analysis that investigates the statistical isotropy in the Local Universe using the Arecibo Legacy Fast ALFA (ALFALFA) survey data (0 &lt; z &lt; 0.06). We investigate the angular distribution of H i extragalactic sources from the ALFALFA catalogue and study whether they are compatible with the statistical isotropy hypothesis using the two-point angular correlation function (2PACF). Aware that the Local Universe is plenty of clustered structures and large voids, we compute the 2PACF with the Landy–Szalay estimator performing directional analyses to inspect 10 sky regions. We investigate these 2PACF using power-law best-fitting analyses, and determine the statistical significance of the best-fitting parameters for the 10 ALFALFA regions by comparison with the ones obtained through the same procedure applied to a set of mock catalogues produced under the homogeneity and isotropy hypotheses. Our conclusion is that the Local Universe, as mapped by the H i sources of the ALFALFA survey, is in agreement with the hypothesis of statistical isotropy within $2\sigma$ confidence level, for small- and large-angle analyses, with the only exception of one region – located near the Dipole Repeller – that appears slightly outlier ($2.4\sigma$). Interestingly, regarding the large angular distribution of the H i sources, we found three regions where the presence of cosmic voids reported in the literature left their signature in our 2PACF, suggesting projected large underdensities there, with number-density contrast δ ≃ −0.7. According to the current literature, these regions correspond, partially, to the sky position of the void structures known as Local Cosmic Void and Dipole Repeller.