bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey on the state of the art of force myography technique (FMG): analysis and assessment
Authors: Sherif Omar , Bassuoni Mohamed Mahgoub , Mehrez Omar 
Published: February 2024

AbstractPrecise feedback assures precise control commands especially for assistive or rehabilitation devices. Biofeedback systems integrated with assistive or rehabilitative robotic exoskeletons tend to increase its performance and effectiveness. Therefore, there has been plenty of research in the field of biofeedback covering different aspects such as signal acquisition, conditioning, feature extraction and integration with the control system. Among several types of biofeedback systems, Force myography (FMG) technique is a promising one in terms of affordability, high classification accuracies, ease to use, and low computational cost. Compared to traditional biofeedback systems such as electromyography (EMG) which offers some invasive techniques, FMG offers a completely non-invasive solution with much less effort for preprocessing with high accuracies. This work covers the whole aspects of FMG technique in terms of signal acquisition, feature extraction, signal processing, developing the machine learning model, evaluating tools for the performance of the model. Stating the difference between real-time and offline assessment, also highlighting the main uncovered points for further study, and thus enhancing the development of this technique.
Graphical abstract
PLCD3 inhibits apoptosis and promotes proliferation, invasion and migration in gastric cancer
Authors: Yu Yantao , Baral Shantanu , Sun Qiannan , Ding Jianyue , Zhang Qi , Zhao Fanyu , Gao Shuyang , Yao Qing , Yu Haoyue , Liu Bin , Wang Daorong 
Published: February 2024

AbstractGastric cancer (GC) is a heterogeneous disease whose development is accompanied by alterations in a variety of pathogenic genes. The phospholipase C Delta 3 enzyme is a member of the phospholipase C family, which controls substance transport between cells in the body. However, its role in gastric cancer has not been discovered. The purpose of this study was to investigate the expression and mechanism of action of PLCD3 in connection to gastric cancer. By Western blot analysis and immunohistochemistry, PLCD3 mRNA and protein expression levels were measured, with high PLCD3 expression suggesting poor prognosis. In N87 and HGC-27 cells, the silencing of PLCD3 using small interfering RNA effectively induced apoptosis and inhibited tumor cell proliferation, invasion, and migration. Conversely, overexpression of PLCD3 using overexpressed plasmids inhibited apoptosis in AGS and BGC-823 cells and promoted proliferation, migration, and invasion. In order to investigate the underlying mechanisms, we conducted further analysis of PLCD3, which indicates that this protein is closely related to the cell cycle and EMT. Additionally, we found that overexpression of PLCD3 inhibits apoptosis and promotes the development of GC cells through JAK2/STAT3 signaling. In conclusion, PLCD3 inhibits apoptosis and promotes proliferation, invasion, and migration, which indicated that PLCD3 might serve as a therapeutic target for gastric cancer.
Service evaluation of an embedded Early Intervention in Psychosis programme
Authors: Connolly Paula , Carey Cornelia , Staunton John , Harney Bridget , Chambers Liah , Clarke Ana-Maria , McLaughlin Patrick , Kerins Kathy , Kearney Katrina , Whitty Peter 
Published: February 2024

Abstract

Background:
An average of 1300 adults develop First Episode Psychosis (FEP) in Ireland each year. Early Intervention in Psychosis (EIP) is now widely accepted as best practice in the treatment of conditions such as schizophrenia. A local EIP programme was established in the Dublin South Central Mental Health Service in 2012.

Methods:
This is a cross-sectional study of service users presenting to the Dublin South Central Mental Health Service with FEP from 2016 to 2022 following the introduction of the EIP programme. We compared this to a previously published retrospective study of treatment as usual from 2002 to 2012.

Results:
Most service users in this study were male, single, unemployed and living with their partner or spouse across both time periods. Cognitive Behavioural Therapy for psychosis was provided to 12% (n = 8) of service users pre-EIP as compared to 52% (n = 30) post-programme introduction (p < 0.001), and 3% (n = 2) of service users engaged with behavioural family therapy pre-EIP as opposed to 15% (n = 9) after (p < 0.01). Rates of composite baseline physical healthcare monitoring improved significantly (p < 0.001).

Conclusion:
Exclusive allocation of multidisciplinary team staff to EIP leads to improved compliance with recommended guidelines, particularly CBT-p, formal family therapy and physical health monitoring.
Transnational Echoes of Spenceanism: A Text-Mining Exploration in English-Language Newspapers (1790–1850)
Authors: Cazzola Matilde , Küsters Anselm 
Published: February 2024

AbstractBy tracing mentions of the English radical thinker Thomas Spence (1750–1814), his revolutionary “Plan”, and his disciples (the “Spencean Philanthropists”) in digitized collections of English-language Irish, Caribbean, Indian, Australian, Canadian, and US-American newspapers in the 1790s–1840s, this article explores the dissemination of the ideas and militancy inspired by Spence (“Spenceanism”) across the British Empire and the United States. By applying Digital Humanities methods to investigate British radical history from a transnational perspective, the global reception of Spenceanism is reconstructed by examining and comparing a corpus of 275 newspaper articles through text-mining methods such as keyword analysis, co-occurrences, and sentiment analysis. These methods enable the identification of key themes in references to Spenceanism and advance hypotheses concerning both their geographical and chronological distribution: not only when and where Spence and the Spenceans were alluded to and commented upon, but also how a newspaper's geographical location may have impacted its rhetoric in a specific year and historical context. By combining quantitative and qualitative analysis, this article contributes new insights regarding the global circulation of radical ideas across the nineteenth-century English-reading world.
Affective and sensory–motor norms for idioms by L1 and L2 English speakers
Authors: Morid Mahsa , Sabourin Laura 
Published: February 2024

AbstractIn the present study, we developed affective (valence and arousal) and sensory–motor (concreteness and imageability) norms for 210 English idioms rated by native English speakers (L1) and English second-language speakers (L2). Based on internal consistency analyses, the ratings were found to be highly reliable. Furthermore, we explored various relations within the collected measures (valence, arousal, concreteness, and imageability) and between these measures and some available psycholinguistic norms (familiarity, literal plausibility, and decomposability) for the same set of idioms. The primary findings were that (i) valence and arousal showed the typical U-shape relation, for both L1 and L2 data; (ii) idioms with more negative valence were rated as more arousing; (iii) the majority of idioms were rated as either positive or negative with only 4 being rated as neutral; (iv) familiarity correlated positively with valence and arousal; (v) concreteness and imageability showed a strong positive correlation; and (vi) the ratings of L1 and L2 speakers significantly differed for arousal and concreteness, but not for valence and imageability. We discuss our interpretation of these observations with reference to the literature on figurative language processing (both single words and idioms).
Constitutional Liberties and Cyberspace: Analysing the Anuradha Bhasin v Union of India Case and its Impact on Fundamental Rights
Authors: Juyal Rebant 
Published: February 2024

AbstractThe right to free speech and expression is a fundamental right guaranteed under Article 19 (1) (a) of part III of the Indian constitution. The fundamental rights act as the constitutional restraints over the state's authority to intervene within the protective gamut of civil liberties of the people. However, the Indian judiciary remains the principal enforcer of the constitutional liberties guaranteed as fundamental rights whenever breached by the state. As the interpreters of the constitution and guardians of civil liberties, the Indian constitutional courts have consistently acted to protect people from state-authorised interventions in their respective domains of fundamental rights. To this concept, this research article by Rebant Juyal attempts to study the landmark judgment of the Indian Supreme Court in the case of Anuradha Bhasin v Union of India, where the court upheld the fundamental right of people to express their speech and expression on the internet.
Transgenderism, Othering and Third Way Buddhist Monasticism in Chiang Mai, Thailand
Authors: Kidpromma Amnuaypond , Taylor James L. 
Published: February 2024

AbstractReligion and trans studies are a relatively new domain of study, one which surrounds subjects gendered and sexed as (religiously) “Other,” and in the articulation of such voices in a public space. In this paper we employ a case study of a transgendered monastic teacher named Khun Mae Tritrinn in northern Thailand to highlight a case of gendered religious “Othering,” and the construction of the third-way religiosity in the context of traditional hetero-patriarchal Buddhist monasticism. We refer to this thematic domain in the context of an emergent third-way religiosity; theorising in an experiential knowing of transgender subjects, which emerges from their trans-other lives. In the case study we show by resisting the gender binary of Buddhist monasticism how a particular transgendered person seeks a third-way monastic alternative; how she established her own hermitage and religious community, and manages the relationship between discourse and institutions that act upon and through her. The ethnographic focus sheds light on historical moments and voices that have been referred to elsewhere as forms of “subjugated knowledge” (Foucault 1980; Hartman 2000). However, despite being subject to religious Othering, recent trans-other identities have gained an increasingly de-subjugated and respected third-space alternative; an intelligibility and opening beyond a heteronormative binarism. It is argued that religious “thirding” creates a turning point for those seeking alternative spiritual bases, and as a salvific epistemology in an engaged religiosity and praxis.
Electrical Properties of Vertical Dominant Charge Structures Observed in Corsican Thunderstorms With a LMA
Authors: Houel Ronan , Defer Eric , Lambert Dominique , Prieur Serge , Pédeboy Stéphane 
Published: February 2024

AbstractLightning characteristics of Corsican storms with different charge structures are investigated in this study. Observations of an LMA network are used to document the total lightning activity. Complementary lightning observations of the lightning detection network Météorage are also used. A clustering algorithm is used to build a database of electrical cells from June to October 2018. A method is also applied to infer the vertical charge structure, as dominant dipoles, per 10‐min period for each electrical cell. As an example, one cell recorded in July 2018 is discussed. The cell database is then presented as well as the main electrical properties according to the dominant charge structures. For instance, the higher in altitude the dominant dipole, the higher the flash rate. Overall, dominant negative dipole are observed for 25% of the 10‐min periods and can be separated into two categories: (a) low altitude negative dipole class dominated by negative cloud‐to‐ground (CG) flashes with a main positive layer located between 2 and 4 km height and (b) high altitude negative dipole class, dominated by negative intracloud (IC) with a main positive layer at 5 km height. Dominant positive dipole can also be separated into two categories with (a) a dominant positive dipole located between 4.5 and 10 km high, −CG dominance, weak flash rate and (b) higher altitude dominant positive dipole, +IC dominance and a larger +CG fraction. The synergistic use of LMA and Météorage observations independently gives a rational type and polarity classification with regard to the vertical charge structure.
Understanding Links Between Water Scarcity and Violent Conflicts in the Sahel and Lake Chad Basin Using the Water Footprint Concept
Authors: Nkiaka Elias , Bryant Robert G. , Kom Zongho 
Published: February 2024

AbstractWhilst there are several empirical studies linking water scarcity and violent conflicts, existing quantitative studies use mostly climate and environmental variables even though such variables have been shown to not be strong predictors of water conflicts by some studies. The aim of this study was to use the water footprint concept and the Falkenmark index to identify water scarcity hotspots at the sub‐national scale and to understand the links between water scarcity and violent conflicts in the Sahel and Lake Chad Basin over a period of two decades (2000–2021). We achieve this by developing five water scarcity metrics at a monthly timescale using runoff, soil moisture, potential evapotranspiration, water consumption and demographic data. The developed metrics show high levels of water scarcity across the study area during the dry, pre‐monsoon and post‐monsoon seasons. Analyses further reveal high green water scarcity (GWS) (soil moisture deficit) and low Falkenmark index scores (water stress) during the dry, pre‐monsoon and post‐monsoon seasons, across all reported water conflict locations. This suggest that there is an indirect link between GWS, the Falkenmark index scores and water conflicts. Results from this study may be used to enhance water management, mitigate, and prevent water conflicts in the study area and likewise the methodology adopted may be used to address water scarcity and conflicts in other regions.
Artificial Space Weathering to Mimic Solar Wind Enhances the Toxicity of Lunar Dust Simulants in Human Lung Cells
Authors: Chang J. H. M. , Xue Z. , Bauer J. , Wehle B. , Hendrix D. A. , Catalano T. , Hurowitz J. A. , Nekvasil H. , Demple B. 
Published: February 2024

AbstractDuring NASA's Apollo missions, inhalation of dust particles from lunar regolith was identified as a potential occupational hazard for astronauts. These fine particles adhered tightly to spacesuits and were unavoidably brought into the living areas of the spacecraft. Apollo astronauts reported that exposure to the dust caused intense respiratory and ocular irritation. This problem is a potential challenge for the Artemis Program, which aims to return humans to the Moon for extended stays in this decade. Since lunar dust is “weathered” by space radiation, solar wind, and the incessant bombardment of micrometeorites, we investigated whether treatment of lunar regolith simulants to mimic space weathering enhanced their toxicity. Two such simulants were employed in this research, Lunar Mare Simulant‐1 (LMS‐1), and Lunar Highlands Simulant‐1 (LHS‐1), which were added to cultures of human lung epithelial cells (A549) to simulate lung exposure to the dusts. In addition to pulverization, previously shown to increase dust toxicity sharply, the simulants were exposed to hydrogen gas at high temperature as a proxy for solar wind exposure. This treatment further increased the toxicity of both simulants, as measured by the disruption of mitochondrial function, and damage to DNA both in mitochondria and in the nucleus. By testing the effects of supplementing the cells with an antioxidant (N‐acetylcysteine), we showed that a substantial component of this toxicity arises from free radicals. It remains to be determined to what extent the radicals arise from the dust itself, as opposed to their active generation by inflammatory processes in the treated cells.
The Green's Function Model Intercomparison Project (GFMIP) Protocol
Authors: Bloch‐Johnson Jonah , Rugenstein Maria A. A. , Alessi Marc J. , Proistosescu Cristian , Zhao Ming , Zhang Bosong , Williams Andrew I. L. , Gregory Jonathan M. , Cole Jason , Dong Yue , Duffy Margaret L. , Kang Sarah M. , Zhou Chen 
Published: February 2024

AbstractThe atmospheric Green's function method is a technique for modeling the response of the atmosphere to changes in the spatial field of surface temperature. While early studies applied this method to changes in atmospheric circulation, it has also become an important tool to understand changes in radiative feedbacks due to evolving patterns of warming, a phenomenon called the “pattern effect.” To better study this method, this paper presents a protocol for creating atmospheric Green's functions to serve as the basis for a model intercomparison project, GFMIP. The protocol has been developed using a series of sensitivity tests performed with the HadAM3 atmosphere‐only general circulation model, along with existing and new simulations from other models. Our preliminary results have uncovered nonlinearities in the response of the atmosphere to surface temperature changes, including an asymmetrical response to warming versus cooling patch perturbations, and a change in the dependence of the response on the magnitude and size of the patches. These nonlinearities suggest that the pattern effect may depend on the heterogeneity of warming as well as its location. These experiments have also revealed tradeoffs in experimental design between patch size, perturbation strength, and the length of control and patch simulations. The protocol chosen on the basis of these experiments balances scientific utility with the simulation time and setup required by the Green's function approach. Running these simulations will further our understanding of many aspects of atmospheric response, from the pattern effect and radiative feedbacks to changes in circulation, cloudiness, and precipitation.
How Can We Improve the Seamless Representation of Climatological Statistics and Weather Toward Reliable Global K‐Scale Climate Simulations?
Authors: Takasuka Daisuke , Kodama Chihiro , Suematsu Tamaki , Ohno Tomoki , Yamada Yohei , Seiki Tatsuya , Yashiro Hisashi , Nakano Masuo , Miura Hiroaki , Noda Akira T. , Nasuno Tomoe , Miyakawa Tomoki , Masunaga Ryusuke 
Published: February 2024

AbstractToward the achievement of reliable global kilometer‐scale (k‐scale) climate simulations, we improve the Nonhydrostatic ICosahedral Atmospheric Model (NICAM) by focusing on moist physical processes. A goal of the model improvement is to establish a configuration that can simulate realistic fields seamlessly from the daily‐scale variability to the climatological statistics. Referring to the two representative configurations of the present NICAM, each of which has been used for climate‐scale and sub‐seasonal‐scale experiments, we try to find the appropriate partitioning of fast/local and slow/global‐scale circulations. In a series of sensitivity experiments at 14‐km horizontal resolution, we test (a) the tuning of terminal velocities of rain, snow, and cloud ice, (b) the implementation of turbulent diffusion by the Leonard term, and (c) enhanced vertical resolution. These tests yield reasonable convection triggering and convection‐induced tropospheric moistening, and result in better performance than in previous NICAM climate simulations. In the mean state, double Intertropical Convergence Zone bias disappears, and the zonal contrast of equatorial precipitation, top‐of‐atmosphere radiation balance, vertical temperature profile, and position/strength of subtropical jet are reproduced dramatically better. Variability such as equatorial waves and the Madden–Julian oscillation (MJO) is spontaneously realized with appropriate spectral power balance, and the Asian summer monsoon, boreal‐summer MJO, and tropical cyclone (TC) activities are more realistically simulated especially around the western Pacific. Meanwhile, biases still exist in the representation of low‐cloud fraction, TC intensity, and precipitation diurnal cycle, suggesting that both higher spatial resolutions and further model development are warranted.
An advanced 3D lymphatic system for assaying human cutaneous lymphangiogenesis in a microfluidic platform
Authors: Kim Minseop , Choi Sieun , Choi Dong-Hee , Ahn Jinchul , Lee Dain , Song Euijeong , Kim Hyun Soo , Kim Mijin , Choi Sowoong , Oh Soojung , Kim Minsuh , Chung Seok , Park Phil June 
Published: February 2024

Abstract
The human cutaneous lymphatic system strictly controls lymphatic functions by coordinating with skin cells. The lymphatic system plays important roles in removing cell waste, residual proteins, various antigens, and immune cells from tissues to maintain homeostasis and activate the immune system through the drainage of interstitial fluid1,2. The skin protects our body from external stimuli such as pathogens through the cutaneous lymphatic system3,4. Herein, to develop an in vitro human cutaneous lymphatic model, we present two 3D microfluidic platforms: a lymphangiogenesis model with a precollecting lymphatic vessel-like structure and an advanced lymphangiogenesis model with a functional cutaneous barrier and a precollecting lymphatic vessel-like structure. In addition, we rapidly analyzed prolymphangiogenic effects using methods that incorporate a high-speed image processing system and a deep learning-based vascular network analysis algorithm by 12 indices. Using these platforms, we evaluated the pro-lymphangiogenic effect of Lymphanax, a natural product derived from fresh ginseng. As a result, we demonstrated that Lymphanax induces robust lymphangiogenesis without any structural abnormalities. In conclusion, we suggest that these innovative platforms are useful for studying the interaction between the skin and lymphatic system as well as evaluating the prolymphangiogenic effects of drugs and cosmetics.
Unlocking Li superionic conductivity in face-centred cubic oxides via face-sharing configurations
Authors: Chen Yu , Lun Zhengyan , Zhao Xinye , Koirala Krishna Prasad , Li Linze , Sun Yingzhi , O’Keefe Christopher A. , Yang Xiaochen , Cai Zijian , Wang Chongmin , Ji Huiwen , Grey Clare P. , Ouyang Bin , Ceder Gerbrand 
Published: February 2024

AbstractOxides with a face-centred cubic (fcc) anion sublattice are generally not considered as solid-state electrolytes as the structural framework is thought to be unfavourable for lithium (Li) superionic conduction. Here we demonstrate Li superionic conductivity in fcc-type oxides in which face-sharing Li configurations have been created through cation over-stoichiometry in rocksalt-type lattices via excess Li. We find that the face-sharing Li configurations create a novel spinel with unconventional stoichiometry and raise the energy of Li, thereby promoting fast Li-ion conduction. The over-stoichiometric Li–In–Sn–O compound exhibits a total Li superionic conductivity of 3.38 × 10−4 S cm−1 at room temperature with a low migration barrier of 255 meV. Our work unlocks the potential of designing Li superionic conductors in a prototypical structural framework with vast chemical flexibility, providing fertile ground for discovering new solid-state electrolytes.