bluuebunny/crossref_metadata_2025_split huggingface dataset:
Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients
Authors: Lofredi Roxanne , Krause Patricia , Feldmann Lucia K. , Scheller Ute , Neumann Wolf-Julian , Krauss Joachim K. , Saryyeva Assel , Schneider Gerd-Helge , Faust Katharina , Sander-Thömmes Tilmann , Kühn Andrea A. 
Published: October 2023

Abstract

Dystonia is a hyperkinetic movement disorder that has been associated with an imbalance towards the direct pathway between striatum and internal pallidum. To date, the neuronal underpinnings of this abnormal basal ganglia pathway activity and its link to dystonic symptoms remain unknown. Here, we report invasive recordings from ten dystonia patients via specific deep brain stimulation electrodes that allow for unique parallel recordings of several basal ganglia structures. This entails the striatum, the external and the internal pallidum, thus covering nuclei of the direct and indirect pathway. We show that all recorded basal ganglia nuclei display activity in the low frequency band (3–12 Hz). In addition to a correlation between dystonic symptom severity and low-frequency activity in the internal pallidum (R = .88, P = .001), we demonstrate that dystonic symptoms correlate specifically with low-frequency coupling between striatum and internal pallidum (R = .75, P = 0.009). These findings point towards a pathophysiological role of the direct striato-pallidal pathway in dystonia that is conveyed via coupling in the enhanced low-frequency band. Our study provides novel mechanistic insight into the pathophysiology of dystonia by revealing a link between symptom severity and frequency-specific coupling of distinct basal ganglia pathways.
Detection of Safety Helmet and Mask Wearing Using Improved YOLOv5
Authors: Li Shuangyuan , Lv Yanchang , Liu Xiangyang , Li Mengfan 
Published: October 2023

Abstract
With the advancement of society, ensuring the safety of personnel involved in municipal construction projects, particularly in the context of pandemic control measures, has become a matter of utmost importance. Municipal engineering projects, distinct from other types of engineering endeavors, often unfold within urban environments, are characterized by extended durations, encompass a range of outdoor activities, and are susceptible to the influence of factors such as concurrent operations, traffic, climate, and environmental conditions. Consequently, the approach to safety management in municipal engineering necessitates unique considerations. This paper introduces a method that combines deep learning and target detection technology to propose a lightweight artificial intelligence (AI) detection method capable of simultaneously identifying mask-wearing and safety helmet-wearing individuals. The method primarily incorporates the ShuffleNetv2 feature extraction mechanism within the framework of the YOLOv5s network to reduce computational overhead. Additionally, it employs the ECA attention mechanism and optimized loss functions to generate feature maps with more comprehensive information, thereby enhancing the precision of target detection. Experimental results indicate that this algorithm improves the mean Average Precision (mAP) value by 4.3%. Furthermore, it reduces parameter and computational loads by 54.8% and 53.8%, respectively, effectively striking a balance between lightweight operation and precision. This study serves as a valuable reference for research pertaining to lightweight target detection in the realm of municipal construction safety measures.
Laboratory Biosafety: a Visual Analysis in the Web of Science Database From 2000 to 2022
Authors: Qi Sunyun , Chen Siyuan , Gao Yanchao , Witte Dries , Molenberghs Geert , Zhang Qifeng , Gu Hua 
Published: October 2023

Abstract
Background: To conduct a visual analysis of institutional publications, individual publications and publication keywords in the field of laboratory biosafety using the Web of Science database from 2000 to 2022.
Methods: The Web of Science database was searched and downloaded for the literature database from January 1, 2000 to December 31, 2022. VOSviewer 1.6.18 was used to study the relation between paper authors, and CiteSpace 6.1.R3 was used to visualize the collaboration between the paper institutions, the paper keywords and the timeline.
Results: The main research institutions included the Centers for Disease Control and Prevention (USA), the University of Chinese Academy of Sciences (China), and the National Institute of Allergy and Infectious Diseases (USA). The collaboration between the research institutions was limited and dispersed. According to the publication keywords, research hotspots and frontiers emphasize the prevention and management of major emerging infectious diseases, the identification and detection of unknown risk factors, and the advancement and application of biotechnology.
Conclusions: Evidently, the centralization of research teams and individuals in the field of laboratory biosafety is not conducive to the growth of disciplinary diversity. In general, laboratory infrastructure, financial investment and policy support are the basic conditions for research, and European and American countries have a clear first-mover advantage. Differences in intellectual property policies and the confidentiality of related research are one of the important factors hindering international cooperation. Focusing on maintaining human life and health and improving people's quality of life is what research should focus on.In the future, it should explore international consultation and cooperation and exchange mechanisms for intellectual property protection, and accelerate the promotion of laboratory infrastructure and policy and financial support.
Macromolecular Proton Fraction and Diffusion Mapping Brain Microstructure in Patients with Major Depressive Disorder: pilot MR trial
Authors: Abramova Victoria , Petrovskiy Evgeniy , Savelov Andrey , Mazhirina Kseniya , Korostyshevskaya Aleksandra 
Published: October 2023

Abstract

In this study, we utilized advanced quantitative MRI techniques, specifically Diffusion Tensor Imaging, Diffusion Kurtosis Imaging, and Мacromolecular Proton Fraction Mapping, to investigate microstructural differences and alterations in the specific regions in patients diagnosed with major depressive disorder. Previous studies have illustrated that the cingulate and prefrontal gyrus, along with the amygdala, are involved in emotional processing and the development of abnormal emotional responses in depression. Our findings revealed no significant interaction between Мacromolecular proton fraction Mapping with depressive disorder. However, patients with major depressive disorder exhibited a statistically significant increase in mean, axial and radial diffusivity (F = 6.3, p = 0.01, F = 5.0, p = 0.03, F = 7.08, p = 0.01, respectively) in the bilateral amygdala compared to healthy controls, as well as in mean and radial diffusivity in the anterior cingulate cortex (F = 5.61, p = 0.02, F = 7.08, p = 0.01, respectively). These results suggest that altered molecular diffusion characteristics in the amygdala and the anterior cingulate cortex may be specifically associated with major depressive disorder. The identification of novel markers for brain microstructural changes could have implications for early prediction of depressive disorder. Our study demonstrates the utility of new quantitative MRI techniques in assessing structural alterations on the molecular level in the brain and enhances our understanding of the pathophysiology of depression.
Microscopic polyangiitis associated with myelodysplastic syndrome mimicking infectious pneumonia, with complications including complete atrioventricular block and fatal intra-alveolar hemorrhage.
Authors: Sudria Axel , Hyvernat Herve 
Published: October 2023

Abstract
The association between ANCA-associated vasculitis and hematologic malignancy has been previously described and remains a rare phenomenon, albeit potentially underdiagnosed. We report the case of an 81-year-old patient with myelodysplastic syndrome who was managed for an infectious-appearing pneumonia, which subsequently complicated into complete heart block and severe acute respiratory distress syndrome with a fatal outcome. The final diagnosis is severe hemorrhagic alveolitis associated with ANCA-associated vasculitis meeting the criteria for microscopic polyangiitis. This article provides an opportunity to discuss the association between ANCA-associated vasculitis and hematologic malignancies and the adverse prognosis associated with it.
Prediction of Tamoxifen Benefit in Premenopausal Breast Cancer Patients Evaluated by Three Methods for Determination of Hormone Receptor Status
Authors: Engström Terese , Ekholm Maria , Fernö Mårten , Lundgren Christine , Nordenskjöld Bo , Stål Olle , Bendahl Pär-Ola , Tutzauer Julia , Rydén Lisa 
Published: October 2023

Abstract
Background
Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomized tamoxifen trial, to determine if any method is superior at identifying patients that benefit from tamoxifen.
Methods
Premenopausal patients (n = 564) were randomized to two years of tamoxifen or no systemic treatment. Estrogen receptor (ER) and progesterone receptor (PR) status by protein expression measured by cytosol-based methods and IHC, and mRNA by GEX analysis were compared in 313 patients with available data from all methods. Kaplan Meier estimates and Cox regression were used to evaluate the treatment-predictive value for recurrence-free interval (RFi) and overall survival (OS). Median follow-up for event-free patients was 26 (RFi) and 33 (OS) years.
Results
The mRNA data of ESR1 and PGR distributed bimodally, patterns confirmed in an independent cohort. Kappa-values between all methods were 0.76 and 0.79 for ER and PR respectively. Tamoxifen improved RFi in patients with ER-positive (ER+) or PR-positive (PR+) tumors (Hazard Ratio (HR) and 95% confidence interval (CI)), cytosol-ER + 0.53 (0.36–0.79); IHC-ER + 0.55 (0.38–0.79); GEX-ER + 0.54 (0.37–0.77); cytosol-PR + 0.49 (0.34–0.72); IHC-PR + 0.58 (0.40–0.85); GEX-PR + 0.55 (0.38–0.80)). Results were similar for OS.
Conclusion
Cytosol-based methods, IHC, and GEX analysis can all identify patients that benefit from two years of tamoxifen with equal performance, indicating that GEX data might be used to guide adjuvant tamoxifen therapy.
The trial is registered on ISRCTN: ISRCTN12474687
Construct the Validity of STEM and Project-based Critical Thinking Skills Test Instruments Using the Rasch Model
Authors: Setyawati Rina Dwi , Prasad Binod , Kathmandu University, Nepalramasdyahsari Agnita Siska , Aini Sindi Nur 
Published: October 2023

Abstract. Students' critical thinking skills are very important abilities in the 21st century. To measure critical thinking skills, a valid and reliable instrument is needed. This article uses the Rasch model to construct an instrument for critical thinking skills on number pattern material whose learning uses STEM PjBL. The development method uses the analysis, design, development, implementation, and evaluation (ADDIE) stages. Data processing uses the Rasch model assisted by the Winstep program. The instrument was tested on 33 public junior high school students in Semarang. The research results include validity, namely the validity test by experts with an average percentage of 92.4% in the very valid category, the quality of the questions in the instrument reliability aspect is good, and the average critical thinking ability of students who use STEM-based and Project Based instruments Learning was 61.46, higher than other classes at 49.79. The critical thinking test instrument is based on STEM and the project needs to be further developed on other materials.
Heterogeneous Catalysis under Continuous Flow Conditions
Authors: Gupta Ashu , Gupta Radhika , Arora Gunjan , Yadav Priya , Sharma Rakesh Kumar 
Published: October 2023

Abstract:
Heterogeneous catalysis using continuous flow processing is one of the most demanding
subjects from the viewpoint of manufacturing industrial-scale organic compounds.
An amalgamation of the two areas of technology, i.e., heterogeneous catalysis and flow
chemistry, has opened new avenues for green synthetic chemistry. These processes are particularly
convenient in terms of short diffusion paths and improved mixing due to the sensing
of high local concentration of catalytic species on solid catalytic surface when the liquid/
gaseous reagents pass through the column, ultimately resulting in quicker and more efficient
reaction with increased reaction rates and higher turnover numbers. It imparts several
key benefits over conventional batch systems, such as time and energy-saving methodologies,
better productivity, reproducibility, economic viability, waste reduction, and ecofriendly
nature. Also, it eradicates the need for any intermediate isolation, separation of catalysts,
and use of excess reagents. The present review article focuses on heterogeneous catalysis
under continuous flow conditions. Various key reactions, for instance, carbon-carbon bond formation, hydrogenation,
condensation, and oxidation, are presented well, along with their recent developments in the manufacturing
of active pharmaceutical ingredients and platform chemicals. Asymmetric catalysis has also been discussed
with its applications in the synthesis of complex organic molecules. It is anticipated that the review article
will proliferate significant interest in modernizing chemical syntheses through continuous flow processes.
A Classification Scheme for Hostile Design
Authors: Rosenberger Robert 
Published: October 2023

A discussion is emerging over what is called “hostile design,” among other names, i.e., the construction of public-space objects in ways that exclude particular usages, and with an alleged effect of discrimination against already vulnerable populations. Critics outline various examples, from spikes added to a ledge to deter loiterers from sitting, to armrests added to a bench to discourage the unhoused from using it as a place to sleep. In an effort to sharpen the notion of hostile design as a critical tool, I develop an original typology, one in which the various examples are organized in terms of the mechanisms through which their hostility is enacted. This sets up reflections on some variables of hostile design—such as their level of “conspicuousness,” and their “domain of effect”—that cut differently across these categories.
YouTube Expectations in a Canvas World
Authors: Burek Pierce Jennifer , Theisen Colleen 
Published: October 2023

How do students’ previous experiences with online educational video shape their expectations of online learning in higher education? Through this exploratory project, we look for ways to bridge the gap between student expectations and the norms of faculty practices in online instruction, which often include recorded video lectures. Our literature review indicates the prevalence of online video in students’ lives before they enroll in master’s programs, and we argue that these prior encounters with online education form an understudied context for student learning in higher education. Expert studies of U.S. online activity indicate the frequency with which users turn to YouTube for answers, and recognized online educational video companies from Complexly to Khan Academy to PBS Studios figure strongly in the resources that people turn to for online learning outside the academy. By analyzing the norms of prominent online educational videos and the production companies that create them, we identify the rhetorical norms of this media. One notable feature of online video production that students see before higher ed is that it is team-produced. We direct attention, through practices identified in the literature and in our experiences in online educational settings, to ways that faculty can respond to this cultural gap to improve learning and instruction. Understanding students’ preceding experiences with online informational videos, collaboration, and drawing on university resources that support media production are among strategies faculty can use to bridge the expectations gap.
Moving Between Scales
Authors: Shang Wenyi 
Published: October 2023

This dissertation employs the perspective of library and information science (LIS) to inform and guide methodological reflections in two interdisciplinary fields, computational social science (CSS) and digital humanities (DH). However, CSS often prioritizes recent digital trace data over archival material from earlier periods, and the large-scale methods used in DH face criticism from humanists for their incapability to capture perspectival and interpretative nuances.
This dissertation blends humanistic and social-scientific approaches to study premodern China, emphasizing the importance of “moving between scales.” It bridges different scales of analysis by transitioning dynamically between them, examines small-scale structures to uncover how they reflect large-scale dynamics, and explores mid-range social phenomena by investigating prosopography of elite society members. Four research questions are posed: (1) What are the challenges and opportunities in investigating a social network based on biased text? (2) How can prosopographical data lead to conclusions about the shifting center of political power? (3) How can structural characteristics in multiple networks reveal changes in political culture? (4) What can bibliographic metadata reveal about the particularity of publishing history of 16th-to-19th-century Chinese books?
By addressing these questions, this dissertation intends to leverage theories and practices of LIS to develop computational models unveiling historical trends. It seeks to contribute to CSS by enhancing social scientists’ understanding on how societies and cultural systems evolve over time, to DH by revealing the historical changes in the longue durée in premodern China, and to LIS by fulfilling its mission of providing an information perspective to traditional academic disciplines.
Data Science Education in iSchools across the Asian-Pacific Region
Authors: Tang Rong , Jiang Jie , Maurici-Pollock Danielle 
Published: October 2023

In this poster, we report preliminary findings of our investigation of data science education in iSchools around the world. For our analysis, we randomly sampled 20 iSchools within the regions of Asian-Pacific, European, and North American. We report here the findings from the 20 iSchools in the Asian Pacific region: these iSchools come from 9 different countries/areas, including China (n=9), Korea (n=3), New Zealand (n=2), Australia (n=1), Malaysia (n=1), Thailand (n=1), Indonesia (n=1), Philippines (n=1), and Taiwan, China (n=1). Of 20 iSchools, 15 had DS course information, with an average of 8.13 per program, range 1-21, and mode 4. The majority of the programs offered DS courses at both the undergraduate and graduate levels (n=11, 73.33%), three (20.00%) offered at the graduate level only, one (6.67%) only offered at the undergraduate level.
In terms of the course coverage, there were 30 unique topics, with 15 topics included in multiple iSchools’ curriculum, and the remaining 15 were uniquely offered by one iSchool. The most common course topics were Data Structure or Data Organization (n=10, 66.67%), Data Mining & Data Warehouse (n=9, 60.00%), Data Visualization (n=6, 40.00%), Introduction to Data Science (n=6, 40.00%), Machine Learning (n=6, 40.00%), and NLP Text Analysis/Text Mining (n=5, 33.33%). Other repeated topics include Research Data Management, Big Data, AI, Programming, Data governance, Data Analytics, and more. Examples for unique course topics were blockchain, Data Asset Management, Data Security, UX, and more. Further coding and analysis for all three regions are in progress.
Pathways to Librarianship
Authors: Roylance Tay , Clarke Rachel , Furgal Tim , Scretching Desiree 
Published: October 2023

Pathways, a joint project between the New York Library Association (NYLA) and the Syracuse University School of Information Studies (iSchool), is guided by four essential research questions: What are people’s current experiences of pathways into and within the library profession? What are the challenges or barriers people face along their pathways? How, if at all, do those challenges vary among library types and settings? How can we reduce or eliminate these barriers with the goal of increasing diversity and representation in New York’s library workforce? These four questions are multifaceted in their potential answers. In order to attempt addressing the problem holistically, Pathways consists of a three-phase plan in which we have dedicated a year to each phase. We are currently on the first phase: Identify. In this phase, we are seeking answers to the first three research questions laid out above via journey mapping sessions held throughout the state of New York. A team of research assistants, two from each regional library consortia, will be trained on research ethics and methods, as well as qualitative data collection and analysis. After training, they will be connected to interview participants within their district in order to conduct in-person journey mapping sessions. Participants will be able to self-identify personal barriers they’ve individually faced, and then can extrapolate based on the overall data trends what the most prevalent roadblocks are for our second phase, in which we will be recruiting stakeholders to brainstorm viable solutions we can then pilot in year three.
Pedagogical Trends in Librarian Support for Open Science Practices in Higher Education
Authors: Gidakovic Sanja 
Published: October 2023

Librarians have an opportunity to collaborate with faculty and students in supporting and teaching transparency in research. Much of the focus in librarianship has been on supporting research practices, for instance, open access publishing, research data management and guidance on pre-registration of studies (Sayre & Riegelman, 2018; Sayre & Riegelman, 2019) or finding and using open access resources for instance, demonstration of Open Educational Resources (OER). However, there is a shift to embed the research practices of open science (OS) and transparency into teaching in higher education. Since open science practices focus on making research processes and data open accessible to the public, librarians can help to educate students and faculty on the benefits of OS practices and provide resources on how to incorporate OS into teaching.
This poster describes the results of an exploratory study focusing on the trends in librarian teaching support for OS practices in higher education. A mixed methods sequential exploratory design was used where a semi-structured interview and survey were administered to describe the current trends in librarian support for teaching OS at higher education institutions. The results indicate that academic librarians have varied approaches to teaching OS and different opportunities to collaborate within institutions. There were common pedagogical OS topics and perspectives on teaching OS practices in higher education.