bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controls on induced polarization in sandy unconsolidated sediments and application to aquifer characterization
Authors: Slater L. D. , Glaser D. R. 
Published: September 2003

Resistivity and induced polarization (IP) measurements (0.1–1000 Hz) were made on clay‐free unconsolidated sediments from a sandy, alluvial aquifer in the Kansas River floodplain. The sensitivity of imaginary conductivity σ″, a fundamental IP measurement, to lithological parameters, fluid conductivity, and degree of saturation was assessed. The previously reported power law dependence of IP on surface area and grain size is clearly observed despite the narrow lithologic range encountered in this unconsolidated sedimentary sequence. The grain‐size σ″ relationship is effectively frequency independent between 0.1 and 100 Hz but depends on the representative grain diameter used. For the sediments examined here, d90, the grain diameter of the coarsest sediments in a sample, is well correlated with σ″. The distribution of the internal surface in the well‐sorted, sandy sediments investigated here is such that most of the sample weight is likely required to account for the majority of the internal surface. We find the predictive capability of the Börner model for hydraulic conductivity (K)estimation from IP measurements is limited when applied to this narrow lithologic range. The relatively weak dependence of σ″ on fluid conductivity (σw) observed for these sediments when saturated with an NaCl solution (0.06–10 S/m) is consistent with competing effects of surface charge density and surface ionic mobility on σ″ as previously inferred for sandstone. Importantly, IP parameters are a function of saturation and exhibit hysteretic behavior over a drainage and imbibition cycle. However, σ″ is less dependent than the real conductivity σ′ on saturation. In the case of evaporative drying, the σ″ saturation exponent is approximately half of the σ′ exponent. Crosshole IP imaging illustrates the potential for lithologic discrimination of unconsolidated sediments. A fining‐upward sequence correlates with an upward increase in normalized chargeability Mn, a field IP parameter proportional to σ″. The hydraulic conductivity distribution obtained from the Börner model discriminates a hydraulically conductive sand–gravel from overlying medium sand.
Quartic moveout coefficient: 3D description and application to tilted TI media
Authors: Pech Andres , Tsvankin Ilya , Grechka Vladimir 
Published: September 2003

Nonhyperbolic (long‐spread) moveout provides essential information for a number of seismic inversion/processing applications, particularly for parameter estimation in anisotropic media. Here, we present an analytic expression for the quartic moveout coefficient A4that controls the magnitude of nonhyperbolic moveout of pure (nonconverted) modes. Our result takes into account reflection‐point dispersal on irregular interfaces and is valid for arbitrarily anisotropic, heterogeneous media. All quantities needed to compute A4can be evaluated during the tracing of the zero‐offset ray, so long‐spread moveout can be modeled without time‐consuming multioffset, multiazimuth ray tracing.The general equation for the quartic coefficient is then used to study azimuthally varying nonhyperbolic moveout of P‐waves in a dipping transversely isotropic (TI) layer with an arbitrary tilt ν of the symmetry axis. Assuming that the symmetry axis is confined to the dip plane, we employed the weak‐anisotropy approximation to analyze the dependence of A4on the anisotropic parameters. The linearized expression for A4is proportional to the anellipticity coefficient η ≈ ε − δ and does not depend on the individual values of the Thomsen parameters. Typically, the magnitude of nonhyperbolic moveout in tilted TI media above a dipping reflector is highest near the reflector strike, whereas deviations from hyperbolic moveout on the dip line are substantial only for mild dips.The azimuthal variation of the quartic coefficient is governed by the tilt ν and reflector dip φ and has a much more complicated character than the NMO–velocity ellipse. For example, if the symmetry axis is vertical (VTI media, ν = 0) and the dip φ < 30°, A4goes to zero on two lines with different azimuths where it changes sign. If the symmetry axis is orthogonal to the reflector (this model is typical for thrust‐and‐fold belts), the strike‐line quartic coefficient is defined by the well‐known expression for a horizontal VTI layer (i.e., it is independent of dip), while the dip‐line A4is proportional to cos4φ and rapidly decreases with dip. The high sensitivity of the quartic moveout coefficient to the parameter η and the tilt of the symmetry axis can be exploited in the inversion of wide‐azimuth, long‐spread P‐wave data for the parameters of TI media.
Petro‐seismic inversion for sandstone properties
Authors: Koesoemadinata Adam P. , McMechan George A. 
Published: September 2003

We use empirical relations derived from laboratory and log data for sandstones to estimate unknown parameters from given parameters. The known and unknown parameters may be any of the following: compressional and shear wave velocities (Vp and Vs), density (ρ), compressional and shear wave quality factors (Qp and Qs), effective pressure (P), frequency (f), water saturation (S), porosity (φ), clay content (C), fluid permeability (k), and Vp/Vs and Qs/Qp ratios. The goal is to obtain estimates of all thirteen of these petro‐seismic variables from subsets of these as input; whether this is achievable depends on the particular combination of input variables. The inversion typically proceeds through a hierarchy of three levels of parameter estimation, in order of the expected reliability of the estimates. First, we solve for the parameters that can be obtained directly from the fitted empirical equations. Then, a grid search is performed to simultanously fit more than one unknown parameter by finding values that best predict the known parameters. Finally, various approximations are invoked to predict values when the inputs are insufficient to use the direct equations or a grid search. These three procedures can be initiated in any desired order and any number of times. Even if the complete set of seismic parameters (Vp, and Vs, ρ, Qp, Qs, and f) are given, it is not possible to uniquely obtain any of the remaining petrophysical variables (S, φ, C, P, or k) directly from the fitted equations without constraints on (or assumptions about) some of the other variables. There is a trade‐off between porosity and clay content that can be resolved by simultaneous fitting of multiple seismic parameters (i.e., Vp, Vs, and Vp/Vs). The predictability of the parameters from various combinations of the available data is expressed using correlation coefficients (R2) and standard deviations. With optimal input combinations, parameters with R2 ≥ 0.8 are (in order from best to worst) Vp, 100/Qp, ρ, Vs, and S. Other parameters with 0.63 ≥ R2 ≤, 0.79 are (in order from best to worst) φ, Qs/Qp, Vp/Vs, ln k, 100/Qs, and C. P and f are the least reliably estimated. All of the seismic parameters can be accurately estimated if all of the petrophysical parameters are known.
Controls of traveltime data and problems of the generalized reciprocal method
Authors: Leung Tak Ming 
Published: September 2003

Traveltime data required for 2D seismic refraction surveys are 2D first arrivals. To obtain a high degree of consistency between traveltime data and the seismic model, it is important to verify that traveltime data are appropriate for interpretation or an inversion process. Controls or checkpoints presented here inspect compatibility among traveltime data. Similar to the ray‐trace check on the consistency of interpretation, these controls provide an objective means of quality assessment of seismic refraction data.The theoretical aspects of the generalized reciprocal method (GRM) are studied because concerns have been raised regarding the accuracy of some interpretations using this method. The problem of the GRM is that the optimum XY value, which is the most important parameter in the method, is assumed to be twice the offset distance. Consequently, based on this unproven assumption, the efficacy of the optimum XY value is somewhat exaggerated.
Reduced‐time migration of transmitted PS waves
Authors: Sheley David , Schuster Gerard T. 
Published: September 2003

We develop the novel theory of transmitted PS migration and show that PS transmitted arrivals in a Gulf of Mexico vertical seismic profile (VSP) data set can be migrated to accurately image a salt sheet even though the receiver array is below the transmitting boundary. We also show that migrating transmitted arrivals is effective in illuminating the base of an orebody invisible to PP reflections. In general, interfaces that bisect wavepath propagation (i.e., the source and receiver are on opposite sides of the interface and therefore invisible to PP reflections) can be imaged by migration of PS transmitted waves. These results suggest that migration of PS transmitted waves opens new opportunities in imaging nearly vertical impedance boundaries that are typically invisible to conventional reflection imaging of crosswell and VSP data.We also present a new interferometric method, denoted as reduced‐time migration, which uses the arrival‐time difference between the direct P‐wave and subsequent events to increase migration accuracy. Reduced‐time migration removes static time shifts in the data, decreases the focusing error due to an incorrect migration velocity model, and relocates reflection or PS transmission events to be closer to their true positions. Although limited to crosswell and VSP geometries, synthetic‐ and field‐data examples show that reduced‐time migration is noticeably more accurate than conventional migration in the presence of static shifts and/or migration velocity errors. The main assumption of reduced‐time migration is that the direct wave samples errors which are representative of errors in the migration aperture. Transmission wavepaths, in general, are subparallel to the direct wave and therefore the two modes encounter similar errors and, hence, reduced‐time migration is effective in improving the focusing of migration energy. For the PP reflection case, the direct wave and the reflected waves often traverse different parts of the earth, therefore, reduced‐time migration will remove static shifts but it is not expected to mitigate velocity errors if the errors are spatially variant. However, if there is a general and consistent bias in the velocity model, reduced‐time migration is expected to deliver improved results over conventional Kirchhoff migration.
Value of Dual-Phase 2-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography in Cervical Cancer
Authors: Yen Tzu-Chen , Ng Koon-Kwan , Ma Shih-Ya , Chou Hung-Hsueh , Tsai Chien-Sheng , Hsueh Swei , Chang Ting-Chang , Hong Ji-Hong , See Lai-Chu , Lin Wuu-Jyh , Chen Jenn-Tzong , Huang Kuan-Gen , Lui Kar-Wai , Lai Chyong-Huey 
Published: September 2003

Purpose: The role of positron emission tomography (PET) with fluorine-18–labeled fluoro-2-deoxy-d-glucose (FDG) in cervical cancer has not yet been well defined. We conducted a prospective study to investigate its efficacy in comparison with magnetic resonance imaging and/or computed tomography (MRI-CT). Materials and Methods: Patients with untreated locally advanced (35%) or recurrent (65%) cervical cancer were enrolled onto this study. In the first part of this study, 41 patients had a conventional FDG-PET (40 minutes after injection), and in the second part, 94 patients received dual-phase PET (at both 40 minutes and 3 hours after injection). The overall results of PET scans were compared with MRI-CT, and the two protocols of PET were also compared with each other. Lesion status was determined by pathology results or clinical follow-up. The receiver operating characteristic curve method with area under the curve (AUC) calculation was used to evaluate the discriminative power. Results: Overall (N = 135), FDG-PET was significantly superior to MRI-CT in identifying metastatic lesions (AUC, 0.971 v 0.879; P = .039), although the diagnostic accuracy was similar for local tumors. Dual-phase PET was also significantly better than the 40-minute PET (n = 94). The latter accurately recognized 70% of metastatic lesions and the former detected 90% (AUC, 0.943 v 0.951; P = .007). Dual-phase FDG-PET changed treatment of 29 patients (31%; upstaging 27% and downstaging 4%). Conclusion: This study shows that dual-phase FDG-PET is superior to conventional FDG-PET or MRI-CT in the evaluation of metastatic lesions in locally advanced or recurrent cervical cancer.
The Phase III Trial in the Era of Targeted Therapy: Unraveling the “Go or No Go” Decision
Authors: Roberts Thomas G. , Lynch Thomas J. , Chabner Bruce A. 
Published: September 2003

Purpose: To review characteristics of contemporary phase III oncology trials and create an explicit framework to help clinical researchers prioritize novel therapies for phase III testing. Methods: We searched the MEDLINE and EMBASE databases for all reviews of phase III trials; cataloged all phase III trials in two national clinical trial databases; and reviewed approval criteria of recently approved oncology drugs from public data provided by the US Food and Drug Administration. Industry data not available elsewhere in the medical literature were obtained from a sourcebook published by a large contract research organization. Results: Phase III oncology trials are the most expensive and time-consuming aspect of the drug development process. The results of these trials continue to exert the greatest influence on the treatment decision of oncologists and remain pivotal to the granting of drug approval. Making optimal decisions about which agents to advance to phase III testing may decrease the overall cost of cancer drug development and limit the number of patients exposed to ineffective drugs. A conceptual decision model for prioritizing novel therapies for phase III testing is presented. Conclusion: Cancer drug development has become more complex and expensive, whereas overall clinical progress remains slow. The transition from phase II to phase III requires a strategic decision that is based on new considerations. A greater investment in phase I and II drug trials may be required to provide the information necessary for phase III planning.
Postoperative Nomogram for Disease-Specific Survival After an R0 Resection for Gastric Carcinoma
Authors: Kattan Michael W. , Karpeh Martin S. , Mazumdar Madhu , Brennan Murray F. 
Published: September 2003

Purpose: Few published studies have addressed individual patient risk after R0 resection for gastric cancer. We developed and internally validated a nomogram that combines these factors to predict the probability of 5-year gastric cancer–specific survival on the basis of 1,039 patients treated at a single institution. Methods: Nomogram predictor variables included age, sex, primary site (distal one-third, middle one-third, gastroesophageal junction, and proximal one-third), Lauren histotype (diffuse, intestinal, mixed), number of positive lymph nodes resected, number of negative lymph nodes resected, and depth of invasion. Death as a result of gastric cancer was the predicted end point. The concordance index was used as an accuracy measure, with bootstrapping to correct for optimistic bias. Calibration plots were constructed. Results: Gastric cancer–specific survival at 5 years was 50%. A nomogram was constructed on the basis of a Cox regression model. The bootstrap-corrected concordance index was 0.80. When compared with the predictive ability of American Joint Committee on Cancer stage, the nomogram discrimination was superior (P < .001). Nomogram calibration appeared to be excellent. Conclusion: A nomogram was developed to predict 5-year disease-specific survival after R0 resection for gastric cancer. This tool should be useful for patient counseling, follow-up scheduling, and clinical trial eligibility determination.
High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin
Authors: Pohl Gudrun , Rudas Margaretha , Dietze Otto , Lax Sigurd , Markis Eva , Pirker Robert , Zielinski Christoph C. , Hausmaninger Hubert , Kubista Ernst , Samonigg Hellmut , Jakesz Raimund , Filipits Martin 
Published: September 2003

Purpose: To determine the predictive value of p27Kip1 in premenopausal women with early-stage hormone receptor–positive breast cancer. Patients and Methods: We retrospectively examined tumor specimens from 512 patients with breast cancer who were enrolled onto Austrian Breast and Colorectal Cancer Study Group (ABCSG) Trial 5. In this trial, premenopausal, hormone receptor–positive breast cancer patients with stage I and II disease were randomly assigned to receive either 5 years of tamoxifen plus 3 years of goserelin or six cycles of cyclophosphamide, methotrexate, and fluorouracil. p27Kip1 expression was assessed by immunohistochemistry, and its association with clinical outcome was determined. Statistical analyses were performed to test for interaction between p27Kip1 status and treatment. Results: High p27Kip1 expression (nuclear p27Kip1 staining in ≥ 50% of tumor cells) independently predicted superior relapse-free survival (RFS) and overall survival (OS) in both the total study population (RFS: relative risk [RR], 0.53; 95% CI, 0.34 to 0.82; P = .004; OS: RR, 0.29; 95% CI, 0.15 to 0.58; P < .001) and patients treated with combination endocrine therapy (RFS: RR, 0.32; 95% CI, 0.16 to 0.63; P = .001; OS: RR, 0.16; 95% CI, 0.05 to 0.53; P = .003). The interaction between p27Kip1 expression and treatment was statistically significant for RFS (P = .04) but not for OS (P = .27). Conclusion: High p27Kip1 expression was an independent predictor of responsiveness to hormonal therapy and thus may be useful for the selection of premenopausal women with early-stage hormone receptor–positive breast cancer for adjuvant combination endocrine therapy.
Analysis of Surgical Salvage After Failure of Primary Therapy in Rectal Cancer: Results From Intergroup Study 0114
Authors: Tepper J.E. , O’Connell M. , Hollis D. , Niedzwiecki D. , Cooke E. , Mayer R.J. 
Published: September 2003

Purpose: Intergroup Study 0114 was designed to study the effect of various chemotherapy regimens delivered after potentially curative surgical resection of T3, T4, and/or node-positive rectal cancer. A subset analysis was undertaken to investigate the prevalence and influence of salvage therapy among patients with recurrent disease. Patients and Methods: Adjuvant therapy consisted of two cycles of fluorouracil (FU)-based chemotherapy followed by pelvic irradiation with chemotherapy and two more cycles of chemotherapy after radiation therapy. A total of 1,792 patients were entered onto the study and 1,696 were assessable. After a median of 8.9 years of follow-up, 715 patients (42%) had disease recurrence, and an additional 10% died without evidence of disease. Five hundred patients with follow-up information available had a single organ or single site of first recurrence (73.5% of all recurrences). Results: A total of 171 patients (34% of those with a single organ or single site of recurrence) had a potentially curative resection of the metastatic or locally recurrent disease. Single-site first recurrences in the liver, lung, or pelvis occurred in 448 patients (90% of the single-site recurrences), with 159 (35%) of these undergoing surgical resection for attempted cure. Overall survival differed significantly between the resected and nonresected groups (P < .0001), with overall 5-year probabilities of .27 and .06, respectively. Controlling for worst performance status at the time of recurrence does not alter this relationship. Patients who underwent salvage surgery had significantly increased survival (P < .001) for each site. Conclusion: Attempted surgical salvage of rectal cancer recurrence is performed commonly in the United States. The chance of a long-term cure with such intervention is approximately 27%.
Altered Expression of MLH1, MSH2, and MSH6 in Predisposition to Hereditary Nonpolyposis Colorectal Cancer
Authors: Renkonen Elise , Zhang Yange , Lohi Hannes , Salovaara Reijo , Abdel-Rahman Wael M. , Nilbert Mef , Aittomäki Kristiina , Järvinen Heikki J. , Mecklin Jukka-Pekka , Lindblom Annika , Peltomäki Päivi 
Published: September 2003

Purpose: A considerable fraction (30% to 70%) of families with verified or putative hereditary nonpolyposis colorectal cancer fails to show mutations in DNA mismatch repair (MMR) genes. Our purpose was to address the genetic etiology of such families. Materials and Methods: We scrutinized a population-based cohort of 26 families from Finland that had screened mutation-negative by previous techniques. Blood was tested for allelic messenger RNA (mRNA) expression of MLH1, MSH2, and MSH6 by single nucleotide primer extension (SNuPE), and tumor tissue for MMR protein expression by immunohistochemistry (IHC) as well as for microsatellite instability (MSI). Full-length cDNAs of genes implicated by SNuPE or IHC were cloned and sequenced. Results: Unbalanced mRNA expression of MLH1 alleles was evident in two families. An inherited nonsense mutation was subsequently identified in one family, and complete silencing of the mutated allele was identified in the other family. Extinct protein expression by IHC implicated MLH1 in these two and in four other families, MSH2 in four families, and MSH6 in one family. Although no unequivocal genomic mutations were detected in the latter families, haplotype and other findings provided support for heritable defects. With one exception, all tumors with IHC alterations showed MSI, in contrast to the remaining families, which showed neither IHC changes nor MSI. Conclusion: Our expression-based strategy stratified the present “mutation-negative” cohort into two discrete categories: families linked to the major MMR genes MLH1, MSH2, and MSH6 (11 [42%] of 26) and those likely to be associated with other, as yet unknown susceptibility genes (15 [58%] of 26).