bluuebunny/crossref_metadata_2025_split huggingface dataset:
An inflammatory response-related gene signature can predict the prognosis and impact the immune infiltration of multiple myeloma
Authors: Zhao Qian , Li Feng , Li Jing , Xia Yuan , Wang Jing , Chen Lijuan 
Published: January 2024

AbstractMultiple myeloma (MM) is a highly heterogeneous and incurable disease. Inflammation plays a vital role in cancer genesis and progression. However, the relationship between inflammatory response-related genes (IRRGs) and the prognosis of MM patients remains unknown. We constructed a IRRGs prognosis model by least absolute shrinkage and selection operator regression analysis. Moreover, clinical multivariate regression was performed to identify clinical implications. Gene set enrichment analysis was implemented to conduct its biological properties. CIBERSORT deconvolution algorithm was utilized to calculate the immune cell infiltration in different risk groups. The flow cytometry was utilized to perform protein expression of prognostic gene. A Six-IRRGs (VCAM1, RGS1, KIT, CD81, BLNK, and BIRC3) prognostic risk model was successfully constructed and validated. The risk model was an independent predictor for overall survival. Enrichment analysis revealed autophagy and PI3K–Akt signaling pathways were enriched in the high-risk group. Furthermore, we found CD81 widely impacted on the infiltration of immune cells, especially on monocytes and macrophages2. At last, the role of CD81 in MM was confirmed to be an adverse prognostic factor in clinical. Our study explores the potential application value of IRRGs in MM. These findings may provide new insights into the treatment for MM patients.
FLI-1 is expressed in a wide variety of hematolymphoid neoplasms: a special concern in the differential diagnosis
Authors: Cho Uiju , Cha Hee Jeong , Kim Hyun Jung , Min Soo Kee , Kim Hee Kyung , Jung Hye Ra , Park Gyeongsin , Kim Ji Eun 
Published: January 2024

AbstractFriend Leukemia Virus Integration 1 (FLI-1) is a member of E26 transformation-specific family of transcription factors that participates in hematopoietic and vascular endothelial cell development. Immunohistochemical detection of FLI-1 has been widely used to diagnose vascular tumors or, more evidently, Ewing’s sarcoma. However, the expression pattern of FLI-1 in hematolymphoid neoplasms remains unclear. Therefore, in this study, we aimed to investigate the expression of FLI-1 in these tumors, focusing on high-grade lesions, which presents a diagnostic challenge by mimicking Ewing’s sarcoma. We evaluated the expression FLI-1 in various types of lymphoid and plasmacytic tumors, including 27 plasmablastic lymphomas, 229 diffuse large B-cell lymphomas, 22 precursor T- or B-lymphoblastic lymphomas, 24 angioimmunoblastic-type nodal T-follicular helper cell lymphomas, 52 peripheral T-cell lymphomas, NOS, 18 Burkitt lymphomas, 18 non-gastric lymphomas of mucosa-associated lymphoid tissue, 38 chronic lymphocytic leukemia/small lymphocytic lymphomas, 15 mantle cell lymphomas, 23 gastric MALT lymphomas, 50 plasma cell myelomas, and 38 follicular lymphomas. We calculated the H-scores of FLI-1 immunostaining, ranging from 0 to 200, and used the scores to analyze the clinicopathological significance of FLI-1 statistically. FLI-1 was expressed to varying degrees in all types of hematological tumors. FLI-1 expression was detected in 84.1% of patients (466/554). FLI-1 was highly expressed in precursor T- or B-lymphoblastic lymphomas. Follicular lymphomas exhibited low FLI-1 expression. In plasmablastic lymphoma, 85.2% of the patients were focally positive for FLI-1. FLI-1 expression did not correlate with clinicopathological variables, such as demographic data or disease stage, in patients with plasmablastic lymphoma and diffuse large B-cell lymphoma. However, FLI-1 overexpression was associated with poorer overall survival in patients with plasmablastic lymphoma. This study demonstrates that FLI-1 is expressed in various hematolymphoid neoplasms. FLI-1 expression can lead to diagnostic confusion, especially in small blue round cell tumors, such as lymphoblastic lymphoma, plasmablastic lymphoma, and plasma cell myeloma, when distinguishing tumors positive for CD99 and CD56 without CD3, CD20, or CD45. Our findings also suggested the possibility of FLI-1 as a potential prognostic biomarker for plasmablastic lymphoma.
The relationship between peripheral T follicular helper cells and disease severity in systemic sclerosis
Authors: Sahinoglu Melek , Sargin Gokhan , Yavasoglu Irfan , Senturk Taskin 
Published: January 2024

AbstractWe aimed to investigate the association between follicular T helper cells (Tfh) and disease severity in systemic sclerosis (SSc), a chronic connective tissue disease characterized by progressive fibrosis. While Tfh cells have been extensively studied in other autoimmune diseases, their role in SSc remains poorly understood. A cohort of 50 SSc patients, diagnosed based on the ACR/EULAR 2013 classification criteria, was included in the study. Patient data, including demographic information, comorbidities, treatment history and organ involvement, were collected. Disease severity was assessed using the modified Rodnan skin score and Medsger disease severity index. Statistical analyses were performed, considering a p value of < 0.05 as statistically significant. 38% had SSc with limited skin involvement, while 62% had SSc with extensive skin involvement. However, there were no statistically significant differences observed in the levels of CD4+ CXCR5+ , CD4+ ICOS+ , CD4+ CD40L+ and CD4+ PD+ lymphocytes between the two groups. Notably, SSc patients with Raynaud’s phenomenon, digital ulcer and lung involvement exhibited higher levels of CD4+ CXCR5+ lymphocytes compared to those without these manifestations. Furthermore, a significant positive correlation was observed between CD4+ CXCR5+ lymphocyte levels and the severity of lung disease according to the Medsger disease severity index. Based on these findings, we conclude that elevated levels of Tfh cells are associated with lung involvement in SSc and there is a significant correlation between Tfh cell levels and the severity of lung disease. These observations suggest a potential role for Tfh cells in the pathogenesis of lung involvement in SSc and may guide the development of targeted therapies for this aspect of the disease.
Monitoring urban biological invasions using citizen science: the polyphagous shot hole borer (Euwallacea fornicatus)
Authors: Potgieter Luke J. , Cadotte Marc W. , Roets Francois , Richardson David M. 
Published: January 2024

AbstractBenefits provided by urban trees are increasingly threatened by non-native pests and pathogens. Monitoring of these invasions is critical for the effective management and conservation of urban tree populations. However, a shortage of professionally collected species occurrence data is a major impediment to assessments of biological invasions in urban areas. We applied data from iNaturalist to develop a protocol for monitoring urban biological invasions using the polyphagous shot hole borer (PSHB) invasion in two urban areas of South Africa. iNaturalist records for all known PSHB reproductive host species were used together with data on localities of sites for processing plant biomass to map priority monitoring areas for detecting new and expanding PSHB infestations. Priority monitoring areas were also identified using the distribution of Acer negundo, a highly susceptible host that serves as a sentinel species for the detection of PSHB infestations. iNaturalist data provided close to 9000 observations for hosts in which PSHB is known to reproduce in our study area (349 of which were A. negundo). High-priority areas for PSHB monitoring include those with the highest density of PSHB reproductive hosts found close to the 140 plant biomass sites identified. We also identified high-priority roads for visual and baited trap surveys, providing operational guidance for practitioners. The monitoring protocol developed in this study highlights the value of citizen or community science data in informing the management of urban biological invasions. It also advocates for the use of platforms such as iNaturalist as essential tools for conservation monitoring in urban landscapes.
Ensemble-based history matching of the Edvard Grieg field using 4D seismic data
Authors: Lorentzen Rolf J. , Bhakta Tuhin , Fossum Kristian , Haugen Jon André , Lie Espen Oen , Ndingwan Abel Onana , Straith Knut Richard 
Published: January 2024

AbstractThe Edvard Grieg field is a highly complex and heterogeneous reservoir with an extensive fault structure and a mixture of sandstone, conglomerate, and shale. In this paper, we present a complete workflow for history matching the Edvard Grieg field using an ensemble smoother for Bayesian inference. An important aspect of the workflow is a methodology to check that the prior assumptions are suitable for assimilating the data, and procedures to verify that the posterior results are plausible and credible. We thoroughly describe several tools and visualization techniques for these purposes. Using these methods we show how to identify important parameters of the model. Furthermore, we utilize new compression methods for better handling large datasets. Simulating fluid flow and seismic response for reservoirs of this size and complexity requires high numerical resolution and accurate seismic models. We present a novel dual-model concept for a better representation of seismic data and attributes, that deploy different models for the underground depending on simulated properties. Results from history matching show that we can improve data matches for both production data and different seismic attributes. Updated parameters give new insight into the reservoir dynamics, and are calibrated to better represent water movement and pressure.
Existential Social Work in Coping with Death and Grief
Authors: Temiz Rıdvan 
Published: January 2024

AbstractThis article delves into the use of existential social work in coping with death and grief. After defining death and grief, the article explores individuals' attitudes towards death and the theoretical perspectives related to death and grief. The article further examines the fundamental concept of existentialism within the context of coping with death and grief. The article then considers the theoretical basis of an existentialist approach to social work evaluation and intervention. It highlights the importance of an existentialist approach in the process of coping with death and grief, as it encourages individuals to confront the reality of death and find meaning in life. Ultimately, the article contributes to the field of social work by providing insights into the theoretical foundations of existential social work in the context of death and grief. In order to enhance understanding, this article includes a case example, contributing to a deeper understanding of the practical application of existential social work in dealing with death and grief.
Regulatory Stringency and Emission Leakage Mitigation
Authors: Antoniou Fabio , Hatzipanayotou Panos , Tsakiris Nikos 
Published: January 2024

AbstractWe construct a two-country trade model where emissions are an input in production and generate cross-border pollution. We examine the strategic incentives of an active regulator who sets a binding level of emissions in production. We show that, in the presence of terms of trade and emission leakage strategic motives, tighter regulation can mitigate emission leakage, reduce global pollution, and improve a country’s welfare. This result and the corresponding policy implications depend on the relative magnitude of emissions intensities of goods between sectors and on their relationship in production and consumption.
Covariational reasoning in Bayesian situations
Authors: Büchter Theresa , Eichler Andreas , Böcherer-Linder Katharina , Vogel Markus , Binder Karin , Krauss Stefan , Steib Nicole 
Published: January 2024

AbstractPrevious studies on Bayesian situations, in which probabilistic information is used to update the probability of a hypothesis, have often focused on the calculation of a posterior probability. We argue that for an in-depth understanding of Bayesian situations, it is (apart from mere calculation) also necessary to be able to evaluate the effect of changes of parameters in the Bayesian situation and the consequences, e.g., for the posterior probability. Thus, by understanding Bayes’ formula as a function, the concept of covariation is introduced as an extension of conventional Bayesian reasoning, and covariational reasoning in Bayesian situations is studied. Prospective teachers (N=173) for primary (N=112) and secondary (N=61) school from two German universities participated in the study and reasoned about covariation in Bayesian situations. In a mixed-methods approach, firstly, the elaborateness of prospective teachers’ covariational reasoning is assessed by analysing the arguments qualitatively, using an adaption of the Structure of Observed Learning Outcome (SOLO) taxonomy. Secondly, the influence of possibly supportive variables on covariational reasoning is analysed quantitatively by checking whether (i) the changed parameter in the Bayesian situation (false-positive rate, true-positive rate or base rate), (ii) the visualisation depicting the Bayesian situation (double-tree vs. unit square) or (iii) the calculation (correct or incorrect) influences the SOLO level. The results show that among these three variables, only the changed parameter seems to influence the covariational reasoning. Implications are discussed.
Homotopy equivalent boundaries of cube complexes
Authors: Fernós Talia , Futer David , Hagen Mark 
Published: January 2024

AbstractA finite-dimensional CAT(0) cube complex X is equipped with several well-studied boundaries. These include the Tits boundary$$\partial _TX$$

∂
T

X

(which depends on the CAT(0) metric), the Roller boundary$${\partial _R}X$$

∂
R

X

(which depends only on the combinatorial structure), and the simplicial boundary$$\partial _\triangle X$$

∂
▵

X

(which also depends only on the combinatorial structure). We use a partial order on a certain quotient of $${\partial _R}X$$

∂
R

X

to define a simplicial Roller boundary $${\mathfrak {R}}_\triangle X$$

R
▵

X

. Then, we show that $$\partial _TX$$

∂
T

X

, $$\partial _\triangle X$$

∂
▵

X

, and $${\mathfrak {R}}_\triangle X$$

R
▵

X

are all homotopy equivalent, $$\text {Aut}(X)$$

Aut
(
X
)

-equivariantly up to homotopy. As an application, we deduce that the perturbations of the CAT(0) metric introduced by Qing do not affect the equivariant homotopy type of the Tits boundary. Along the way, we develop a self-contained exposition providing a dictionary among different perspectives on cube complexes.
Agroforestry Distribution and Contributions in Ancient Hawaiian Agriculture
Authors: Lincoln Noa Kekuewa , Lee Tiffany M. , Quintus Seth , Haensel Thomas P. , Chen Qi 
Published: January 2024

AbstractAgriculture is one of the most fundamental ways in which human societies interact with the environment. The form and function of agriculture have important socio-political implications in terms of yields, labor requirements, variability and resilience, and elite control. Hawai‘i has been used as a model system for the discussion of coupled human and natural systems, and how the uneven distribution of agricultural opportunities has manifested in the political ecology. However, consideration of agriculture has emphasized forms with physical infrastructure documented through archaeology and have not included arboricultural forms that were extensive among Pacific Islands. We leverage existing, independent data sets to build and validate spatial models of two intensities of arboriculture across the Hawaiian archipelago: Agroforestry and Novel Forest. Model validation demonstrates good accuracy that includes both expected and unexpected sources of errors. Results of the models demonstrate that arboricultural techniques accounted for ~70% of the agricultural potential by area and ~40% of the agricultural potential by yield. Unlike existing agricultural forms modeled, such as flooded wetland terrace cultivation and rainfed field production, which have strong distributional patterns based on the age of the islands, arboricultural potential is well distributed across all the islands. The extent, distribution, and characteristics of arboricultural methods provide important augmentation of the current narrative of production dynamics and distribution, and the political ecology, of pre-contact Hawai‘i.
Quality of Life in Hungarian Parents of Autistic Individuals
Authors: Volgyesi-Molnar Marta , Gyori Miklos , Eapen Valsamma , Borsos Zsofia , Havasi Agnes , Jakab Zoltan , Janoch Laszlone , Nemeth Vivien , Oszi Tamasne , Szekeres Agota , Stefanik Krisztina 
Published: January 2024

Abstract

Purpose
Parents of autistic individuals have been known to have a lower overall quality of life (QQL) than those of typically developing children. We present the first Hungarian large-sample study whose objective was to explore the differences in QOL between parents of autistic individuals (AS) and those of neurotypical (NT) persons.

Methods
Based on the ABCX model we developed a questionnaire comprising standardized scales to characterize the life of parents involved. Our data came from parents of 842 individuals (ASD = 521, NT = 321) between 0 and 49 years. Battery deployed standardized instruments to examine quality of life (WHO-QQL BREF and Quality of Life in Autism questionnaire, QOLA). We assessed the families’ socio-economic/demographic characteristics, parents’ psychological well-being, the autistic/neurotypical individuals’ characteristics, and the interventions.

Results
Our data showed significantly lower QOL in parents of autistic individuals in all domains of questionnaires. We analyzed 20 relevant factors to uncover the predictors of parental QOL. We confirmed the existence of most but not all predictors present in earlier literature and identified intervention-related predictors.

Conclusion
Our study confirms the importance of supporting parents in their role, and of providing health and social supports that focus on quality of life, in addition to child care.
Washing machine ownership and girls' school attendance: a cross-sectional analysis of adolescents in 19 middle-income countries
Authors: Karlsson Omar , De Neve Jan-Walter 
Published: January 2024

AbstractExcessive work among adolescents may compromise educational development. Without home appliances, household work can take over 50 h a week and an additional 30 h when an infant is present. School-aged girls are often tasked with doing laundry, which is time-consuming and inflexible without a washing machine. We determined the association between washing machine ownership and school attendance among adolescents ages 10–19 years in 19 middle-income countries between 2000 and 2021 (N = 1,622,514). We controlled for socioeconomic and demographic characteristics, all neighborhood-level factors, and examined differences by sex, age, household wealth, and period. No relationship between washing machine ownership and school attendance was found in most countries: However, there was a substantial association for girls in Türkiye and a small to moderate association for girls in Egypt and Albania. In Türkiye, for example, girls living in households with a washing machine had 28% (95% CI 19, 37) greater school attendance compared to girls living in households which did not. No association was observed for boys. The results suggest that household ownership of a washing machine does generally not improve school attendance among girls, except possibly in specific contexts.
Different energy storage techniques: recent advancements, applications, limitations, and efficient utilization of sustainable energy
Authors: Kumar Raj , Lee Daeho , Ağbulut Ümit , Kumar Sushil , Thapa Sashank , Thakur Abhishek , Jilte R. D. , Saleel C. Ahamed , Shaik Saboor 
Published: January 2024

AbstractIn order to fulfill consumer demand, energy storage may provide flexible electricity generation and delivery. By 2030, the amount of energy storage needed will quadruple what it is today, necessitating the use of very specialized equipment and systems. Energy storage is a technology that stores energy for use in power generation, heating, and cooling applications at a later time using various methods and storage mediums. Through the storage of excess energy and subsequent usage when needed, energy storage technologies can assist in maintaining a balance between generation and demand. Energy storage technologies are anticipated to play a significant role in electricity generation in future grids, working in conjunction with distributed generation resources. The use of renewable energy sources, including solar, wind, marine, geothermal, and biomass, is expanding quickly across the globe. The primary methods of storing energy include hydro, mechanical, electrochemical, and magnetic systems. Thermal energy storage, electric energy storage, pumped hydroelectric storage, biological energy storage, compressed air system, super electrical magnetic energy storage, and photonic energy conversion systems are the main topics of this study, which also examines various energy storage materials and their methodologies. In the present work, the concepts of various energy storage techniques and the computation of storage capacities are discussed. Energy storage materials are essential for the utilization of renewable energy sources and play a major part in the economical, clean, and adaptable usage of energy. As a result, a broad variety of materials are used in energy storage, and they have been the focus of intense research and development as well as industrialization. This review article discusses the recent developments in energy storage techniques such as thermal, mechanical, electrical, biological, and chemical energy storage in terms of their utilization. The focus of the study has an emphasis on the solar-energy storage system, which is future of the energy technology. It has been found that with the current storage technology, the efficiency of the various solar collectors was found to be increased by 37% compared with conventional solar thermal collectors. This work will guide the researchers in making their decisions while considering the qualities, benefits, restrictions, costs, and environmental factors. As a result, the findings of this review study may be very beneficial to many different energy sector stakeholders.