bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chloroprocaine 3% for anesthesia during cesarean section in a patient with dopa-responsive dystonia: a case report
Authors: zhou wenqin , Luo Dong 
Published: October 2023

Abstract

Background
Dopa-responsive dystonia (DRD) is a rare autosomal dominant hereditary disorder with a prevalence of 0.5 per million population. The disease is characterized by onset of dystonia in childhood, progressive aggravation of the dystonia with diurnal fluctuation, and complete or near complete alleviation of symptoms with low-dose oral levodopa. The incidence of DRD is low, and only a few publications have described this disorder connected with anesthesia.
Case presentation
We present a case involving a pregnant woman with DRD who continued levodopa/benserazide throughout the pregnancy. The perioperative anesthesia management was described. We used chloroprocaine 3% for epidural anesthesia during cesarean section.
Conclusion
In summary, levodopa/benserazide was continued throughout our patient’s pregnancy with a good obstetric outcome, and chloroprocaine was safely used in epidural anesthesia without deterioration of her dystonic symptoms.
Pioneering Discoveries in Wireless Power Generation across Wide Geographical Ranges Harnessing Medium-Wave Radio Broadcasting Infrastructure
Authors: Shoji Eiichi 
Published: October 2023

Abstract
This study conducted field experiments using the radio-wave energy harvester of hoop-shaped radio (HOOPRA) to elucidate the relationship between the distance from the medium-wave (MW) radio broadcasting station and the resonance voltage as an index of harvested energy. Accordingly, we derived a numerical equation that described the relationship between the distance and voltage with a strong correlation coefficient of R2 > 0.996. HOOPRA can illuminate ultrabright white, green, and red LEDs within a 5 km radius of the public NHK JOFG (927 kHz, 5 kW) in Fukui, thereby serving as a valuable energy source for the 150,000 residents (60,000 households) in this region. The public JOAK (594 kHz, 300 kW) and JOAB (693 kHz, 500 kW) were examined for similar field experiments in the Kanto region. The results revealed that HOOPRA could illuminate ultrabright white, green, and red LEDs within a radius of 30 km and ultrabright red LEDs within a radius of 50 km from JOAB, which will benefit the 23 million residents (1.1 million households) in this region.
Implementing a PROM tool to improve the supportive care services referral patterns of adult idiopathic pulmonary fibrosis patients in a pulmonary clinic: A quality improvement pilot project
Authors: FOWORA TEMITOPE 
Published: October 2023

Abstract
Background: Delayed referrals to supportive care services often result in impaired health-related quality of life (HRQL) among patients with idiopathic pulmonary fibrosis (IPF). Pulmonologists can adhere to the ATS clinical treatment guidelines through the use of the patient-reported outcome measure (PROM) tool, which can improve referral to supportive care services.
Local problem: No PROM tool in the pulmonary clinic could assess patients' health-related quality of life (HRQL) of patients due to the disease burden of Idiopathic pulmonary fibrosis (IPF), hence delayed referral to supportive care services.
Method:  A pre and post-retrospective analysis of the chart
Intervention: The King's Brief Interstitial Lung Disease (KBILD) questionnaire was implemented as an evidenced-based PROM tool in the pulmonary clinic
Result: The use of the K-BILD questionnaire increased pulmonologist's awareness of stability or progression of disease burden among IPF patients based on HRQL, hence an increase in the referral of patients to supportive care services
Conclusion: The results suggest that implementing an evidence-based PROM tool such as the KBILD questionnaire can increase referrals to supportive care services in a busy pulmonary clinic
Technology everywhere! But who’s got the time? The influence of time pressures on technology integration in Australian secondary mathematics
Authors: Zunica Ben 
Published: October 2023

Abstract
Over the past 30 years, teachers have been urged to increase their use of digital technology in the classroom. However, mathematics teachers have been slow to integrate ICT, even though mathematics is naturally aligned with technology. While researchers have documented a variety of time and other related factors that contribute to this resistance, there has been little in-depth analysis of teacher reasoning that inhibits technology integration in mathematics. This article presents four case studies of secondary mathematics teachers employed in Australian schools that investigates the adverse effects of time pressures in not only inhibiting a teacher’s desire to use technology but removing as an option altogether. Data was collected in the form of interviews, lesson planning documentation and notes from observation lessons. Thematic analysis was used to determine how time pressures inhibited participants ability to use technology in their pedagogy. Three time-related obstacles were identified. The first was a lack of time to prepare lessons, the second was content-laden syllabuses and finally, the need to prepare students for traditional assessments. Participants claimed that these obstacles often proved too great to overcome, causing them to abandon any use of technology. I argue that when the obstacles to technology integration are perceived as too difficult to overcome, it is not enough to provide poorly targeted professional learning or encouragement to work harder to integrate technology. Rather, existing time pressures must be alleviated in terms of workload and syllabus demands if we want to remove the inhibitors to technology integration in mathematics.
Connecting the changing metallomic spectrum and survival in sarcoma: a pilot study
Authors: Collet Laetitia , Telouk Philippe , Albarede Francis , Girodet Magali , Maqua Clémence , Rogasik Muriel , Ducimetière Françoise , Tabone-Eglinger Séverine , Brahmi Mehdi , Dufresne Armelle , Thomas David M , Ballinger Mandy L , Blay Jean-Yves , Ray-Coquard Isabelle 
Published: October 2023

Abstract

Background
The role of metals and trace elements in the progression of cancer can be both passive and active. While some metals have clearly emerged as carcinogens, the homeostasis of other trace elements only trails cancer evolution and therefore offers some potential prognostic values. At this stage, modern-standard datasets including a large number of elements are missing. The present analysis established a first metallomic spectrum by relating the blood concentration of metals and trace elements in patients with sarcoma with survival data.
Methods
Patients with sarcoma and controls were retrospectively selected from the International Sarcoma Kindred Study database. Blood samples were prospectively collected at the Leon Bérard Cancer Center from February 2012 to July 2019. Stable specimens and copper isotopes (65Cu/63Cu) were analyzed using Triple Quadrupole ICP-MS and the MC-ICP-MS Nu Plasma HR 500. Wilcoxon rank sum test, log-rank test, and multivariate Cox regression models were used for statistics.
Results
In total, 151 patients and 59 healthy controls were included. At the time of blood sample collection, 62% of patients had locally advanced or metastatic disease, and 49% were undergoing chemotherapy. The median overall survival (OS) was 16.6 months. Copper (Cu), copper/zinc (Cu/Zn) and potassium /rubidium (K/Rb) ratio were significantly higher in patients compared to controls, whereas δ65Cu, selenium (Se), sulfur (S), Rb, K, phosphorus (P), iron (Fe) and Se / S ratio were significantly lower. Cu, Cu / Zn and K / Rb were also significantly higher in advanced compared to early stage disease. Of note, whereas S and Se were significantly correlated in patients, no correlation was observed in controls. Importantly, levels of K, Rb, Se, Fe, P, Si, S, δ65Cu, Cu, S / Se and Cu/Zn ratio were independently associated with OS.
Conclusions
These results depict the metallomic spectrum in sarcoma and highlight substantial variation associated with survival, some of them paving the way for future anti-cancer therapy development
Circumscribed ferroelectricity by phonon-decoupled oxygen tetrahedra in brownmillerite oxides
Authors: Choi Si-Young , Jang Jinhyuk , Jin Yeongrok , Park Heung-Sik , Kim Jaegyu , Kang Kyeong Tae , Go Kyoung-June , Kim Gi-Yeop , Hong Seungbum , Lee Jun Hee , lee Daesu , Han Myung Geun , Zhu Yimei , Cheong Sang-Wook , Yang Chan-Ho , Choi Woo Seok , Lee Jaekwang 
Published: October 2023

Abstract
Ultimate scaling limit in ferroelectric switching has been attracting broad attention in the fields of materials science and nanoelectronics1,2. Despite the immense efforts to scale down ferroelectric features, however, only few materials have been shown to exhibit ferroelectricity at the unit cell level3,4. Here, we report a controllable unit cell-scale domain in the brownmillerite oxides consisting of alternating octahedral/tetrahedral unit cells. By combining atomic-scale imaging and in-situ transmission electron microscopy, we directly probed unit cell-wide ferroelectricity patterned by neutral unit cell-wide walls and its switchable characteristics. The first-principles phonon calculations confirm that the phonon modes related with oxygen-octahedra are fully decoupled from those with oxygen-tetrahedra in the brownmillerite oxides, and such localized oxygen-tetrahedral phonons stabilize the unit cell-wide domain. Unit cell-wide ferroelectricity in our study provides unprecedented scaling limit of ferroelectric thin films for designing high-density memory devices at the quantum limit.
Effectiveness of low frequency vibration on the rate of canine retraction:A randomized controlled clinical trial
Authors: ElMotaleb Mohamed Atfy Abd , El-Beialy Amr Ragab , El-Sharaby Fouad Aly , ElDakroury Amr Emad , Eid Ahmed Abdelsalam 
Published: October 2023

Abstract
Objectives: To investigate the effectiveness of AcceleDent Aura vibrating device on rate of canine retraction.
Materials and Methods: Thirty-two patients requiring extraction of upper first premolars and canine retraction were randomly allocated with a 1:1 ratio into either no-appliance group or the AcceleDent Aura appliance group. Canine retraction was done applying 150gm of retraction force using NiTi coil springs on 16*22 stainless steel archwires. The duration of the study was 4 months. Digital models were obtained directly after extraction of upper first premolars and at monthly intervals during canine retraction for recording the monthly as well as the total distance moved by the canine. Digitized models were superimposed on the initial model and data were statistically analyzed. Anchorage loss, rotation, tipping, torque and root condition were evaluated using cone beam computed tomography imaging. Pain was evaluated by visual analog scale.
Results: No patients were dropped-out during this study. There was no statistically significant difference between both groups regarding the total distance travelled by the canine (P=0.436), as well as the rate of canine retraction per month (P=0.17). Regarding the pain level, there was no statistically significant difference between the two groups at day 0 (P=0.721), after 24 hrs.(P=0.882), after 72 hrs. (P=0.378) and after 7 days(P=0.964).
Conclusion: AcceleDent Aura was not able to accelerate orthodontic tooth movement. Pain level couldn’t be reduced by vibrational force with an AcceleDent device during orthodontic treatment. Root condition was not affected by the vibrational forces.
A step towards sustainability: Life cycle assessment of coffee produced in the indigenous community of Ocotepec, Chiapas, Mexico
Authors: Carrillo-Arriola Atzin Elihu , Navarro Perla Xochitl Sotelo 
Published: October 2023

Abstract
Coffee is one of the tropical crops of great relevance. Mexico occupies one of the first places to produce it. Chiapas is the state that contributes the most significant amount of grain to the national and international market, harvested by organized groups such as cooperatives of origin indigenous. In these regions, cultivation is divided into five stages: cultivation, harvest, wet processing, dry processing and roasting. Thus, the agroecological approach based on the agroforestry system of coffee in the community of Ocotepec allowed generating an intercultural dialogue with a Zoque indigenous cooperative, where its members expressed the need to develop information regarding their production process and thus take the relevant decisions. Concerning environmental impacts. The life cycle analysis was applied as a methodological tool to evaluate the process of producing a kilogram of ground coffee in its honey and speciality varieties offered to the national market, showing the most significant impacts for both types of coffee. Cultivation level (water consumption around 80% and land use with effects close to 98%), wet processing (impacting the ecotoxicity of water sources close to 99% followed by marine ecotoxicity with 73%) and in its distribution stage affecting at least 15 environmental categories, likewise, comparative tests were carried out to calculate the carbon footprint and the water footprint, with shade-grown honey coffee being the type of coffee that has the most negligible environmental impact and contributes the most profits to the cooperative.
Occurrence characteristics and ecological risk assessment of microplastics in Urban river in cold regions during ice-covered periods
Authors: Chen Lei , Liao YingFei , Zeng Kangjun , Wu Yining , Wang He 
Published: October 2023

Abstract
The ice-covered periods is a natural phenomenon where ice forms on the water surface of rivers in areas with high latitude and cold climate. Ice blocks the diffusion of pollutants, thus causing changes in water quality characteristics. This paper focuses on the Harbin section of the Songhua River in the cold region of northern China. The occurrence characteristics and pollution level of microplastics (MPs) are explored in both ice and water of urban inland rivers and estuaries during the ice-covered periods. The results identified the discharge of domestic sewage as the main source of MPs in urban inland rivers. The abundance of MPs in MaJiaGou average of 324.36 ± 261.45 item/L, the abundance of MPs in SongHua ice raverage of 65.02 ± 68.15 item/L, while in the water with different depths of SongHua, the MPs it ranged from 1.03 ± 0.66 item/L to 12.86 ± 9.35 item/L,average is 5.59 ± 7.57 item/L.The amount of MPs in ice is about 11 times that in water.Ice formation caused a decline in MPs prevalence within the aquatic environment primarily due to the inclusion of a relatively large proportion of MPs within the ice mass during freezing. Additionally, it restricted atmospheric MPs from entering the river waters, contributing to the decrease.The abundance of MPs in urban inland rivers gradually increased from south to north, while that in the mainstream of the Songhua River showed an increasing trend from east to west. Detected MPs were mainly fibrous and white in shape and color, respectively, with a particle size < 0.5 mm. The fragmentation of micro plastics in ice is greater than that in water. Polyethylene, polypropylene, and polyacrylonitrile,etc were the main types of polymers. The results of ecological risk assessment showed that the MPs pollution in the Harbin section of the Songhua River reached moderate and severe pollution levels during the ice-covered periods Its potential risk should receive more attention and control should be strengthened. The research results have important reference significance for providing basic information for river pollution control and ecological protection in cold regions, providing a new direction for future research. In the future, more attention should be directed to the transfer and toxic effects of environmental MPs.
Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility
Authors: Chander Atul Munish , Teixeira Marcus Melo , Singh Nitin K. , Williams Michael P. , Parker Ceth W. , Leo Patrick , Stajich Jason E. , Torok Tamas , Tighe Scott , Mason Christopher E. , Venkateswaran Kasthuri 
Published: October 2023

Abstract

Members of the family Trichomeriaceae, belonging to the Chaetothyriales order and the Ascomycota phylum, are known for their capability to inhabit hostile environments characterized by extreme temperatures, nutrient scarcity (oligotrophic conditions), presence of toxic compounds, or drought conditions. Within this family, the genus Knufia encompasses the vast majority of polyextremophilic species. In this report, the genomic and morphological features of the strain FJI-L2-BK-P2, identified as Knufia obscura, are presented. The identification is based on multi-locus sequence analysis and whole genome sequence phylogeny. The strain FJI-L2-BK-P2 was isolated from the Mars 2020 mission spacecraft assembly facility located at the Jet Propulsion Laboratory in Pasadena, California. Additionally, the type strain of K. obscura (CBS 148926T), originally isolated from a car's gas tank in Italy, has been sequenced and annotated. The morphological analysis and description of the genomic characteristics of K. obscura FJI-L2-BK-P2 may contribute to refining the taxonomy of Knufia species. Key morphological features are reported in this K. obscura strain, resembling microsclerotia and chlamydospore-like propagules. These features, known to be significant in black fungi, could potentially facilitate their adaptation to harsh environments.
Fingolimod Attenuates Lung Injury after Diffuse Brain Injury
Authors: Feng Dongyi , Zhang Xinjie , Xiang Tangtang , Su Wanqiang , Liu Tao , Li Fanjian , Qian Yu , Fan Yibing , Li Wanjing , An Shuo , Tian Yu , Jiang Rongcai 
Published: October 2023

Abstract
One of the severe and common extracranial injuries associated with severe traumatic brain injury (TBI), such as diffuse brain injury (DBI), is acute lung injury (ALI). The inflammatory reaction plays a key role in ALI development. Fingolimod inhibits multiple inflammatory responses. We hypothesized that fingolimod administration could attenuate ALI by modulating the inflammatory reaction secondary to TBI. Fingolimod was administered for 3 consecutive days after DBI. Immunohistochemistry and hematoxylin and eosin staining were performed for histopathological evaluation to assess the degree of inflammatory cell infiltration and ALI after DBI. Pulmonary edema and capillary leakage were quantified by assessing the lung wet-to-dry ratio and Evans blue dye leakage. Western blotting was used to assess the concentrations of inflammatory factors, blood–air barrier tight junction proteins, and apoptosis proteins in lung tissue after DBI. Flow cytometry was used to analyze the peripheral blood Treg content and to evaluate the changes in peripheral immunity after DBI. It was found that DBI induced significant lung injury and caused changes in the peripheral blood Treg content. Fingolimod treatment significantly alleviated lung barrier injury and reduced inflammatory cytokine production, inflammatory cell infiltration, apoptotic protein levels, and the wet/dry weight ratio in lung tissue 3 days after DBI, accompanied by an increase in the peripheral blood Treg content. Thus, it was found that DBI can result in significant pulmonary damage accompanied by significant inflammatory responses. Fingolimod reduced the inflammatory response and alleviated DBI-induced lung injury, providing a potential new approach for the treatment of ALI in DBI.
First Evidence on Genomic Potential of Stenotrophomonas Rhizophila Strain Is26 Able to Reduce Aflatoxin B1 Produced by Aspergillus Flavus in a Solid-based Medium
Authors: Dif Guendouz , Djemouai Nadjette , Belaouni Hadj Ahmed , Meklat Atika , Toumatia Omrane , Zitouni Abdelghani 
Published: October 2023

Abstract
This work aimed to study the interaction between Stenotrophomonas rhizophila strain IS26 and an isolate of Aspergillus flavus NRRL 62477 able to synthesize aflatoxin B1. Our results demonstrated that, when co-cultivated with A. flavus on ISP2 medium, the strain IS26 reduced the aflatoxin B1 residual concentration by 47%. The assembly of 5189077 Illumina's paired-end sequencing reads resulted in 42 contigs for a total genome assembly size of 4.09 Mb with 66.4% GC content. An overall total of 3624 genes was predicted using the NCBI Prokaryotic Genome Automatic Annotation Pipeline (NCBI-PGAAP). A total of 304 subsystems with 27% subsystem coverage was predicted using RAST annotation of the S. rhizophila strain IS26 genome. The genome sequence analysis of the strain IS26 detected the presence of genes involved in inhibition of aflatoxins (Afs) biosynthesis as well as genes involved in the degradation of AFs. Thus, these results suggest that S. rhizophila IS26 decreased aflatoxin B1 via down-regulated gene expression in terms of aflatoxin B1 biosynthesis and/or degradation of Afs. In summary, S. rhizophila IS26 can be employed for the biological reduction of aflatoxin B1 produced by A. flavus NRRL 62477.
Adherence to dental home care in dogs with periodontitis: a post-treatment survey
Authors: Svärd John , Enlund Karolina Brunius 
Published: October 2023

Abstract
Background
Periodontitis is a common disease in dogs, and daily dental home care in the form of tooth brushing is essential for prevention and treatment. Despite this, many studies reveal low adherence to tooth brushing advice. This study aimed to assess compliance with dental home care among dogs with periodontitis and understand the factors influencing brushing routines. A questionnaire survey was emailed to 63 dog owners whose dogs had been diagnosed with periodontitis, received dental cleaning at the University Animal Hospital, and were given tooth brushing instructions. The survey was supplemented by telephone interviews, resulting in a 57% response rate.
Results
The study presents dog owners' routines, experiences, attitudes, and motivation regarding tooth brushing. Approximately 42% brushed their dogs' teeth daily while others did so less frequently or not at all. Reported challenges, such as uncooperative dogs and difficulty establishing a routine, may explain infrequent brushing.
Conclusions
While the study suggests that owners of dogs with periodontitis tend to follow dental care recommendations better than the general dog owner population, it also reveals that preventive care is inadequate for more than half of the dogs. Given the high prevalence of periodontitis, there's a need for resources to address infrequent tooth brushing. Understanding dog owners' needs can help establish daily brushing as a routine, improving canine oral health and overall well-being.
Perceived isolation, social disconnectedness, and the mental health of young adults in South Korea
Authors: Choi Seongsu , Lee Yeongju , Park Sojeong 
Published: October 2023

Abstract

Background
While perceived isolation and social disconnectedness in older adults and adolescents are considered to be risk factors for mental health, limited research on the association between these variables in young adults. This study aims to investigate the prevalence of perceived isolation and social disconnectedness among young adults in Korea and the impact of these factors on mental health.
Methods
We utilized data from the 2021 Young Adult Socio-economic Survey, which approved by Statistics Korea. A sample of 2,041 participants was selected. Logistic regression analysis was conducted to examine the association between perceived isolation and social disconnectedness and mental health.
Results
Perceived isolation and social disconnectedness were associated with mental health. Perceived isolation (OR 1.86, 95% CI = 1.61–2.15) and going out (OR 2.59, 95% CI = 1.47–4.58) significantly influenced depression. Additionally, subjective well-being was significantly influenced by perceived isolation (OR 1.17, 95% CI = 1.03–1.33), going out (OR 1.96 95% CI = 1.21–3.16), and number of friends (OR 0.79, 95% CI = 0.69–0.90).
Conclusions
Overall, the findings suggest that social connection is crucial to young adults’ mental health.