bluuebunny/crossref_metadata_2025_split huggingface dataset:
CO2 Electroreduction To Syngas With Tunable Composition In An Artificial Leaf
Authors: Veenstra Florentine L. P. , Cibaka Thérèse , Martín Antonio J. , Weigand Daniel , Kirchhoff Joachim , Smirnov Vladimir , Merdzhanova Tsvetelina , Pérez‐Ramírez Javier 
Published: January 2024

AbstractInvited for this month's cover is the group of Javier Pérez‐Ramírez at ETH Zürich, which collaborated with the group of Tsvetelina Merdzhanova at Forschungszentrum Jülich. The image shows how artificial leaves, able to recycle carbon dioxide into syngas of variable composition, could be integrated with chemical plants. The Research Article itself is available at 10.1002/cssc.202301398.
Diagnostic models for predicting malignancy in thyroid nodules classified as Bethesda Category III in an endemic region
Authors: Kasap Zeliha Aydın , Kurt Burçin , Özsağır Elif , Ercin Mustafa Emre , Güner Ali 
Published: January 2024

AbstractBackgroundThis study aims to develop a diagnostic model to help physicians determine whether thyroid nodules categorized as atypia of undetermined significance (AUS) in category III of the Bethesda system are benign or malignant preoperatively. To create a diagnostic model for predicting thyroid nodules' benign or malignant with AUS cytology based on clinical, ultrasonographic, and cytopathological findings.MethodsThis is a retrospective cohort study involving patients (>19) at risk of thyroid cancer who had thyroidectomy after an AUS cytology. The dataset consists of 53 variables 204 nodules from 183 patients. Binary logistic regression and factor analysis methods were used to identify risk factors for malignancy. Finally, four prediction models were developed using different approaches, based on clinical, pathological clinical + pathological, and the factors.ResultsA total of 88 (48.1%) of 183 patients diagnosed with AUS were benign and 95 (51.9%) the malignant. After determining risk factors, four prediction models were developed based on different approaches to assist physicians in deciding to detect AUS nodules early. It was seen that bilaterality was found to be a risk factor for malignancy in the clinical model (pbilaterality = .03) and it was also seen that the pathological variables pale chromatin and irregular contours in the oncocyte variables were risk factors for malignancy (ppalechromatin = .02, pirregularcontoursintheoncocyte = .04). The best model obtained sensitivity and specificity values are 73% and 87% based on clinical and pathological variables.ConclusionThis comprehensive study may provide a more in‐depth understanding of AUS and make a notable contribution to healthcare professionals before surgery.
The role of autophagy in insulin resistance and glucolipid metabolism and potential use of autophagy modulating natural products in the treatment of type 2 diabetes mellitus
Authors: Yang Xiaoxue , Ding Wenwen , Chen Ziyi , Lai Kaiyi , Liu Ying 
Published: January 2024

AbstractType 2 diabetes mellitus (T2DM) is a severe, long‐term condition characterised by disruptions in glucolipid and energy metabolism. Autophagy, a fundamental cellular process, serves as a guardian of cellular health by recycling and renewing cellular components. To gain a comprehensive understanding of the vital role that autophagy plays in T2DM, we conducted an extensive search for high‐quality publications across databases such as Web of Science, PubMed, Google Scholar, and SciFinder and used keywords like ‘autophagy’, ‘insulin resistance’, and ‘type 2 diabetes mellitus’, both individually and in combinations. A large body of evidence underscores the significance of activating autophagy in alleviating T2DM symptoms. An enhanced autophagic activity, either by activating the adenosine monophosphate‐activated protein kinase and sirtuin‐1 signalling pathways or inhibiting the mechanistic target of rapamycin complex 1 signalling pathway, can effectively improve insulin resistance and balance glucolipid metabolism in key tissues like the hypothalamus, skeletal muscle, liver, and adipose tissue. Furthermore, autophagy can increase β‐cell mass and functionality in the pancreas. This review provides a narrative summary of autophagy regulation with an emphasis on the intricate connection between autophagy and T2DM symptoms. It also discusses the therapeutic potentials of natural products with autophagy activation properties for the treatment of T2DM conditions. Our findings suggest that autophagy activation represents an innovative approach of treating T2DM.
Evolution of two‐pore domain potassium channels and their gene expression in zebrafish embryos
Authors: Park Sung Jun , Silic Martin R. , Staab Peyton L. , Chen Jiapei , Zackschewski Ethan L. , Zhang GuangJun 
Published: January 2024

AbstractBackgroundThe two‐pore domain potassium (K2P) channels are a major type of potassium channels that maintain the cell membrane potential by conducting passive potassium leak currents independent of voltage change. They play prominent roles in multiple physiological processes, including neuromodulation, perception of pain, breathing and mood control, and response to volatile anesthetics. Mutations in K2P channels have been linked to many human diseases, such as neuronal and cardiovascular disorders and cancers. Significant progress has been made to understand their protein structures, physiological functions, and pharmacological modifiers. However, their expression and function during embryonic development remain largely unknown.ResultsWe employed the zebrafish model and identified 23 k2p genes using BLAST search and gene cloning. We first analyzed vertebrate K2P channel evolution by phylogenetic and syntenic analyses. Our data revealed that the six subtypes of the K2P genes have already evolved in invertebrates long before the emergence of vertebrates. Moreover, the vertebrate K2P gene number increased, most likely due to two whole‐genome duplications. Furthermore, we examined zebrafish k2p gene expression during early embryogenesis by in situ hybridization. Each subgroup's genes showed similar but distinct gene expression domains with some exceptions. Most of them were expressed in neural tissues consistent with their known function of neural excitability regulation. However, a few k2p genes were expressed temporarily in specific tissues or organs, suggesting that these K2P channels may be needed for embryonic development.ConclusionsOur phylogenetic and developmental analyses of K2P channels shed light on their evolutionary history and potential roles during embryogenesis related to their physiological functions and human channelopathies.
Genomic insights into differentiation and adaptation of Amorphophallus yunnanensis in the mountainous region of Southwest China
Authors: Gao Yong , Dai Dongqin , Wang Haibo , Wu Weijia , Xiao Penghui , Wu Lifang , Wei Xiaomei , Yin Si 
Published: January 2024

AbstractThe role of geographical isolation and environmental adaptation in driving the differentiation and radiation of species has been a hotspot in evolutionary biology. The extremely complicated and fragmented geography of the mountainous region of Southwest China provides an excellent system for investigating the process of species divergence in heterogeneous habitats. Amorphophallus yunnanensis is a species of extreme habitat preference that resides mainly in the mountainous region of Southwest China. Here, we used restriction site‐associated DNA sequencing (RAD‐seq) to characterize the geographic pattern of genetic variation among 19 populations of A. yunnanensis as well as the genomic basis of environmental adaptation. A pattern of low population genetic diversity and high level of genetic differentiation was observed. The genomic data revealed a clear east–west genetic differentiation, with two distinct genetic lineages corresponding to the Guizhou plateau and Yunnan plateau, respectively. However, we discovered demographic expansion of the Guizhou Plateau lineage and recent hybridization in populations at the contact region. Significant levels of isolation by distance along with isolation by environment were detected. Outlier tests and genome–environment association analyses identified 89 putatively adaptive loci that might play a role in environmental adaptation. Our results suggest that the genetic divergence of A. yunnanensis is attributed to geographical isolation together with divergent selection in the mountainous region of Southwest China.
Study on the resistance characteristics of layered vegetation to overland flow
Authors: Zhang Lili , Zhang Shengtang , Huang Haiping 
Published: January 2024

AbstractDifferent types of plants in the vegetation community near the surface of the basin coexist, forming a layered vegetation distribution with high and low plants in the morphology. In order to research the characteristics of flow resistance generated by layered vegetation on slope runoff, a flume experiment was carried out by simulating layered vegetation. The Manning roughness coefficient n was used to characterize the flow resistance of vegetation. Three kinds of vegetation with height combinations of 5 and 7 cm, 6 and 8 cm, and 7 and 9 cm were used for this experiment. By studying the relationship between Manning roughness coefficient n and water depth, it is found that the change of flow resistance of layered vegetation is closely related to the submerged state. The distribution of n shows an inverted “J” type with the increase of water depth. Under the condition of nonsubmerged state and transitional submerged state, n increases with the increase of water depth. The critical point n values of the two states will plummet, and the growth rate of n in the nonsubmerged state is greater than that in the completely submerged state. In the transitional submerged state and completely submerged state, the higher the plant height below the water surface, the higher the corresponding n value and the greater the change rate of n. Formula for predicting overland flow resistance of layered vegetation was established by considering the influence of combined vegetation height and Reynolds number.
Non‐uniform voltage distribution characteristics of metallized film capacitors in flexible HVDC projects
Authors: Zhao Zheng , Teng Shangfu , Liu Shuo , Zhao Zixuan , Wang Cong , Tu Youping 
Published: January 2024

AbstractThe problem of non‐uniform voltage distribution in the internal element of metallized film capacitors in flexible HVDC transmission systems exists, the influence of electrical parameters of dielectric and metal copper row are not considered in the existing metallized film capacitor equivalent circuit model. In this paper, the conductance of biaxially oriented polypropylene film (BOPP) for metalized film capacitors is measured at different electric field intensity and dielectric properties at different frequencies. The current density distribution and voltammetric properties of the metalized film capacitor elements under AC and DC superimposed voltages are calculated by the finite element method, and the voltammetric properties of the copper row considering the skin effect are derived. The equivalent circuit model of the metalized film capacitor under the AC‐DC superposition voltage is proposed. The simulation results of the capacitor equivalent circuit model show that the voltage distribution of the internal elements of the capacitor is uniform at low frequency AC voltages (<102 Hz), and the voltage amplitude and phase difference between the elements of the capacitor gradually increases with increasing AC voltage frequency. At an AC voltage frequency of 105 Hz, the difference in magnitude between the two capacitor elements on the same copper row was up to 2.01% and the phase difference was 13.5%, while the difference in magnitude between capacitors at the same horizontal position on different copper rows was up to 56.8% and the phase difference was 10.44%. The results of this paper provide some guidance for the modeling of the internal components of metalized film capacitors, the calculation of voltage distribution and the structural optimization design.
AFHO‐based link reliable routing and power‐assisted channel allocation protocol in cognitive radio networks for healthcare applications
Authors: Sekar Hemalatha , Appranchi Sumathi 
Published: January 2024

AbstractIn the realm of cognitive networks, accommodating the increasing need for radio spectrum to facilitate both secondary and primary users stands as an intricate and demanding task. This study introduces a tailored framework for healthcare applications in Cognitive Radio (CR) networks for link reliable routing and power‐assisted channel allocation. Through the integration of Adaptive Fire Hawk Optimization for routing, the strategy addresses optimization complexities while prioritizing robust link quality via optimal hop selection for effective communication. A new routing optimization challenge is formulated, aiming to establish reliable communication pathways and extend link reliability. Moreover, the framework incorporates power‐assisted channel allocation to strategically enhance resource management and overall network performance. The rigorous evaluation demonstrates significant enhancements across key performance metrics, which showcase percentage improvements of 9.86%, 14.56%, 3.85%, 5.06%, 6.94%, and 17.80% for active nodes, delay, Packet Delivery Ratio (PDR), residual energy, and throughput, respectively. These advancements underscore the proposed approach's efficacy in enhancing CR network performance, particularly for healthcare applications.
Textural dynamic crisping mechanism of crisp grass carp: Oxidative stress, apoptosis, collagen filling, and cross‐linking
Authors: Tang Mi , Shao Ting , Ma Liang , Dai Hongjie , Yong Yu , Feng Xin , Zhang Yuhao 
Published: January 2024

AbstractFeeding faba beans to freshwater fish could crisp its muscle texture to avoid softening. However, the dynamic crisping mechanism was unclear. Herein, a 120‐day feeding trial was conducted to systemically investigate the textural crisping mechanism of crisp grass carp (CGC) via molecular‐level, gene/protein expression analysis. In the early crisping stage (0–30 days), the total antioxidant capacity significantly decreased (by 16.79%), TUNEL staining and qRT‐PCR results revealed that apoptosis occurred, which was induced by oxidative stress validating by proteomics. Meanwhile, the content of dityrosine and hydroxylysyl pyridinoline rose, thereby substantially increasing the hardness and chewiness of CGC by 37.51% and 40.84%, respectively. With further crisping (30–90 days), Masson staining exhibited collagen gradually filling the gap between myofibrils, the content and cross‐linking degree of collagen further increased, finally elevating the hardness and chewiness of CGC. This study laid a theoretical foundation for producing and supplying aquatic raw materials with different texture characteristics.
Exploring the past through lynchet landscapes in the Vosges Mountains and the Lorraine Plateau (France)
Authors: Keller Benjamin , Vincent Robin , Schwartz Dominique , Ertlen Damien 
Published: January 2024

AbstractLynchets are ridges formed by erosion and sediment accumulation downstream of agricultural plots and offer valuable insights into past agricultural activity. These microtopographies cover vast areas and serve as indicators of historical changes in land use. As a result, their ubiquity across Europe makes them particularly interesting. In this study, we propose a geoarchaeological approach to analyze six lynchets, four in the Vosges Mountains and two on the Lorraine Plateau (France). The lynchets can be considered soil archives with no stratigraphic organization or chronological sequence from bottom to top, making it difficult to determine the age of the lynchets and identify changes in land use over time. To this end, we propose the analysis of historical and geo‐historical archives combined with the “pedosedimentary” archives of lynchets through charcoal identification and dating combined with near‐infrared spectroscopy to determine the age, vegetation, and past land use changes associated with lynchet landscapes. By combining these multiple data sources, we are better able to show the chronological development of these ancient agricultural systems and uncover valuable information on landscape history. Charcoal dating suggests a higher frequency of fires from the Middle Ages. The dating aligns with the regional dynamics of anthropogenic fires, indicating a potential use of fire for cultural purposes. We also demonstrate the difficulty of extrapolating the dating of a lynchet to the entire lynchet system. Our results highlight the difficulties of interpreting the formation and dating of lynchets and the lynchet system on the sole basis of charcoal analysis. However, we highlight the value of applying pedoanthracology to lynchets to determine the dynamics of land use change in former fields.
Burnout in emergency department personnel—A continuing concern post pandemic
Authors: Tan Mei Ling , Pek Jen Heng , Wong Shiu Hong 
Published: January 2024

AbstractIntroductionHigh incidences of burnout has been reported amongst emergency department (ED) personnel during the COVID‐19 pandemic. Emerging from the pandemic, organisational support for psychological health may dwindle and become secondary to economic priorities. We aimed to ascertain the level of burnout within ED staff at our hospital, identify professional groups, which were more vulnerable and domains, which contributed most towards burnout.MethodsWe conducted a cross‐sectional study approximately 8 months after major moves to remove COVID‐19 restrictions in Singapore. Data was collected via a self‐administered survey employing the Copenhagen Burnout Inventory (CBI). Demographics, occupational details, work satisfaction and motivation to stay in the job were also collected and analysed.ResultsA total of 115 ED staff participated. Overall CBI score was 62.3 ± 22.0. Scores for personal, work‐related and client burnout were 64.9 ± 23.2, 61.6 ± 23.1 and 60.4 ± 26.1, respectively. A total of 44.5% had to take medical leave because of burnout. Nurses had higher overall CBI scores than doctors (67.5 ± 20.5 vs. 54.6 ± 23.0, p = 0.01). Those who were satisfied with their present job had lower overall CBI scores compared to those not satisfied (42.7 ± 17.9 vs. 84.0 ± 14.4, p < 0.001). Overall CBI scores were also lower in those motivated compared with those not motivated to continue in their current job (50.1 ± 16.3 vs. 79.0 ± 15.1, p < 0.001).ConclusionED staff continue to record high rates of burnout as we transit out of the pandemic. Accompanying rates of medical leave and low levels of motivation to remain in the job are serious occupational health concerns. Factors contributing to burnout in at risk groups such as nurses should be further analysed. High mean CBI scores in the personal and work domains indicate that related factors contribute most towards burnout and interventions should be focused accordingly.
Skeletal muscle index impacts the treatment outcome of elderly patients with diffuse large B cell lymphoma
Authors: Niiyama‐Uchibori Yui , Okamoto Haruya , Miyashita Akihiro , Mizuhara Kentaro , Kanayama‐Kawaji Yuka , Fujino Takahiro , Tsukamoto Taku , Mizutani Shinsuke , Shimura Yuji , Teramukai Satoshi , Kuroda Junya 
Published: January 2024

AbstractSarcopenia is a crucial factor in the physical fitness of elderly individuals. This study investigated the prognostic values of multiple parameters of sarcopenia in association with established prognostic factors in elderly Japanese patients with diffuse large B cell lymphoma (DLBCL). As candidate indicators for sarcopenia, the skeletal muscle index (SMI) (cm2/m2), the psoas muscle index, the erector spinae muscle index, the visceral fat index, the subcutaneous fat index, and the visceral to subcutaneous fat area ratio at the third lumbar level were assessed by computed tomography at their initial diagnosis in 102 patients with DLBCL over 75 years old those were diagnosed and treated in our institute from 2007 to 2020. The primary endpoint was overall survival (OS), and the secondary endpoint was progression‐free survival (PFS). The median age of patients analyzed was 80 years at diagnosis. The sex‐specific cut‐offs for the indices adopted two approaches: (i) the historical cut‐off values established in the previous study for healthy Japanese individuals (Hamaguchi Y. J Cachexia Sarcopenia Muscle. 2018), and (ii) each sex‐specific lowest quartile in our cohort. As the results, SMI evaluated by the historical cut‐off and sex‐specific lowest quartile was identified as the most influential independent prognostic factor for both OS and PFS among various parameters for sarcopenia. Furthermore, we developed an elderly sarcopenia prognostic index (ESPI). ESPI, which combines SMI evaluated by the historical cut‐off and LDH > ULN, demonstrated statistically significant prognostic impacts on OS and PFS. Moreover, compared to the R‐IPI, ESPI showed the ability to identify intermediate‐risk groups and indicated a trend toward improved predictive accuracy. Our study revealed that SMI is the most appropriate assessment method for evaluating sarcopenia and the critical prognostic factor in OS and PFS of elderly patients with DLBCL.
Testing reliability and validity of practitioner‐rated parental sensitivity: A novel tool for practice
Authors: Forrer Mirte L. , Oosterman Mirjam , Tharner Anne , Schuengel Carlo 
Published: January 2024

AbstractImproving parental sensitivity is an important objective of interventions to support families. This study examined reliability and validity of parental sensitivity ratings using a novel package of an e‐learning tool and an interactive decision tree provided through a mobile application, called the OK! package. Independent raters assessed parental sensitivity using the OK! package (N = 11 raters) and the NICHD Parental Sensitivity rating scales (N = 22 raters) on the basis of videotaped mother‐child interactions at 10‐ or 12‐months‐old (N = 294) and at 24‐months‐old (N = 204) from the Dutch longitudinal cohort study Generation2. Mothers reported on children's externalizing and internalizing problems and social competence when children were 4 and 7 years old. Results showed excellent single interrater reliability for raters using the OK! package (mean ICC = .79), and strong evidence for convergent validity at 10‐ or 12‐month‐old (r = .57) and 24‐month‐old (r = .65). Prospective associations of neither parental sensitivity rated using the OK! package or the NICHD Parental Sensitivity rating scales with child developmental outcomes were statistically significant (p > .05), with overlapping 95% confidence intervals for both measures. The OK! package provides a promising direction for testing alternatives to current training and instruction modalities.