bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term bone remodeling of maxillary anterior teeth with post-treatment alveolar bone defect in adult patients with maxillary protrusion: a prospective follow-up study
Authors: Guo Runzhi , Li Linwei , Lin Yifan , Huang Yiping , Liu Jian , Pan Mengqiao , Xu Li , Li Weiran 
Published: November 2023

Abstract
Background
Alveolar bone defects, particularly palatal bone dehiscence (PBD) and labial bone fenestration (LBF), occur frequently as a result of retraction of the maxillary anterior teeth. The study aims to explore the long-term bone remodeling of maxillary anterior teeth in adult patients with post-orthodontic treatment PBD and LBF.

Materials and methods
The study includes 24 adult patients with maxillary protrusion (8 males, 16 females) who were treated with extraction of four first premolars and had alveolar bone defects (PBD or LBF) in maxillary anterior teeth following orthodontic treatment. Cone-beam computed tomography imaging measurements were obtained before (T1), after (T2) orthodontic treatment, and after at least 1-year removable thermoplastic retainer retention (T3). The maxillary anterior teeth with PBD or LBF at T2 were divided into the PBD or LBF groups, respectively. The labial and palatal alveolar bone height (ABH), alveolar bone thickness (ABT), and movement of maxillary anterior teeth were measured during retraction (T2–T1) and retention (T3–T2) periods.

Results
The incidence of PBD and LBF in maxillary anterior teeth significantly increased after orthodontic treatment and decreased during the retention period. In the PBD group, the palatal ABH of all maxillary anterior teeth significantly increased from T1 to T2 but decreased from T2 to T3. The ABT of the maxillary central incisor and canine significantly increased on the palatal side and decreased on the labial side during the retention period. In the LBF group, the labial ABT of the maxillary central incisor at the apical level showed a significant decrease from T1 to T2, followed by an increase from T2 to T3. In both groups, the maxillary central incisor showed significant labial movement, with a relative intrusion during the retention period.

Conclusion
For adult patients with maxillary protrusion, the alveolar bone defect of maxillary anterior teeth caused by orthodontic retraction significantly improved during the retention period, indicating good long-term bone remodeling. Our findings suggest that a combination of spontaneous reorientation of maxillary anterior teeth and bone remodeling contributed to alveolar bone covering in these patients.
Infantile type I pleuropulmonary blastoma presenting with dyspnea due to compression by pneumothorax and an occupying tumor: a case report
Authors: Okamoto Mitsumasa , Kimura Shoka , Hotta Machiko , Tsuruno Yudai , Fukuzawa Hiroaki 
Published: November 2023

AbstractBackgroundPleuropulmonary blastoma (PPB) is an extremely rare and malignant pediatric lung tumor. Purely cystic PPB has a more favorable prognosis than solid PPB, but may be difficult to distinguish from a certain type of “benign” congenital pulmonary airway malformation before and during surgery. The influence of tumor rupture on long life prognosis has not been clarified in detail.Case presentationA 5-month-old boy underwent emergency transfer from another hospital due to a left thoracic cystic lesion and left pneumothorax detected on chest radiography performed for persistent wheeze and cough. Contrast-enhanced computed tomography of the chest revealed marked deviation of the mediastinum to the right due to a giant cystic lesion and pneumothorax. Thoracotomy was performed on hospital day 2. A cystic lesion had developed from the distal alveolar region of lower lobe of the left lung and the tumor showed a tiny adhesion to the left diaphragm and a tiny rupture near the adhesion. Partial lung excision including the cyst and scraping of the adhesion were performed. Histopathological investigations revealed immature blast cell-like mesenchymal cells and differentiated striated muscle cells in a dense cambium layer were found under the epithelium of the cystic lesion. Type I PPB was diagnosed.ConclusionsSurgery should be performed with the possibility of type I PPB in mind when an extrapulmonary cystic lung lesion is found. Since issues such as the pathogenesis and long-term prognosis of ruptured cases remain unclear, continued careful follow-up of this case will be required.
The misbeliefs and food taboos during pregnancy and early infancy: a pitfall to attaining adequate maternal and child nutrition outcomes among the rural Acholi communities in Northern Uganda
Authors: Acire Peter Vivian , Bagonza Arthur , Opiri Nicolas 
Published: November 2023

Abstract
Background
In developing countries, the practice of food taboo is pervasive. The types of foods considered as taboos and the reasons attached to taboos vary from society to society. Food taboos have been recognized as one of the factors contributing to maternal undernutrition in pregnancy, especially in rural settings. In the rural Acholi community where malnutrition is prevalent, very little is known about these food taboos and misbeliefs. This study, therefore, aims to explore various misbeliefs and food taboos in the time of pregnancy that can influence maternal and child nutrition outcomes in Acholi.

Methods
A community-based qualitative cross-sectional study was conducted between April and May 2022 in five districts in the Acholi subregion. Focus group discussions (FGDs) and key informant interviews (KIIs) were used to collect data. Data transcription was done verbatim, organised into themes, assigned unique color codes, and manually analysed thematically.

Results
Upon scrutiny of the transcripts, three themes were eminent. The first theme focused on foods that are considered taboos in Acholi community and the reasons linked to them. Participants indicated offals, chicken, wild birds, smoked meat and fish, sugarcane, garden egg (‘Tula’), groundnut, bush meat, mushrooms, honey, sour fruits, or meals (oranges, mango, passion fruits, lemon, tamarind, ‘Malakwang’), goat’s meat, ‘Lalaa’ (the bitter green leafy vegetable), and ‘Lamola’ (Hyptis spicigera) as the major taboo foods. The second theme was the reasons underlying the adherence to the food taboos and misconceptions. Cultural dictates, individual characteristics, and societal context were the main reasons for the adherence to food taboos. The third theme looked at the misconceptions and other taboos during pregnancy. It was found that pregnant women are not allowed to touch grave soil, shave their hair, walk over an anthill, slaughter chicken or birds, have sex during pregnancy, sit on animal’s hide or skin, and/or touch needles.

Conclusions
Nutritional counseling and education should focus more on addressing food taboos. The mode of delivery of the nutrition message should be inclusive, targeting pregnant women and their spouses, school-going children, adolescent girls, and cultural leaders at their respective points of contact.
Perception and experiences of suicide among university students in Egypt
Authors: Kabbash Ibrahim Ali , Salama Basem , Mohammad Menatollah Ashraf , Galal Hagar , Yousef Noorhan , Elghazally Noha M. 
Published: November 2023

Abstract
Background
The worldwide prevalence of suicide ideation, planning, attempt, and death is a major public health issue. The highest rates of suicide are seen in those aged 15 to 29, largely correlating to their time spent in higher education.

Objectives
Identify the perception and experiences of medical students towards suicidal thoughts and attempts and explore some predictors.

Methods
A cross-sectional study was conducted at Kafrelshiekh University in Egypt, included 554 university students using predesigned questionnaire that included sociodemographic characteristics, perception of students about suicide, and their experience with knowing a person who had suicide thoughts or attempts and if they themselves had suicidal thoughts or attempts.

Results
Self-experience with suicidal thoughts was reported by 25.3% while 12.3% reported attempting suicide, and among those who attempted suicide the most frequent reason was feeling depressed (61.8) followed by educational pressures (54.4%) and feeling lonely (41.2%). Accepting the concept of suicide was the main predictor for having suicidal thoughts (OR = 7.784) followed by knowing a person who had suicidal attempt (OR = 2.234) or thoughts (OR = 4.609).

Conclusion
Our results indicate the suicide ideation and behavior are prevalent among college undergraduates. Universities have the responsibility to educate students with effective life education as well as suicide prevention and intervention programs.
Application of bidirectional LSTM deep learning technique for sentiment analysis of COVID-19 tweets: post-COVID vaccination era
Authors: Akande Oluwatobi Noah , Lawrence Morolake Oladayo , Ogedebe Peter 
Published: November 2023

Abstract
Background
Social media platforms, especially Twitter, have turned out to be a major source of data repositories. They have become a platform that citizens can use to voice their concerns about issues that affect them. Most importantly, during the COVID-19 era, the platform was greatly used by governments and health organizations to sensitize people about the safety guidelines that they must adhere to so as to remain safe during the pandemic. As expected, people also used Twitter and other social media platforms to voice their opinions about how governments are handling the COVID-19 pandemic outbreak. Governments and organizations could, therefore, use these social media as a feedback mechanism that can help them know the view of the citizens about their policies. This could help them in making informed decisions about their policies.

Aim
The aim of this paper is to explore the use of BiLSTM deep learning technique for sentiment analysis of COVID-19 tweets.

Methodology
The study retrieved 197,327 tweets from the Nigeria Twitter domain using #COVID or #COVID-19 hashtags as keywords. The dataset was retrieved within the 1st month of COVID-19 vaccination in Nigeria, i.e., March 15–June 15, 2021. BiLSTM deep learning technique was trained using 789,306 sentiment annotated tweets obtained from Kaggle Sentiment140 tweet datasets. The preprocessed case study tweets were then used to evaluate the proposed model. Also, a precision of 78.26% and a recall value of 78.27% were also obtained.

Results
With an accuracy of 78.29%, 98,545 (49.93%) positive sentiments and 98,782 negative sentiments (50.06%) were recorded. Also, a precision of 78.26% and a recall value of 78.27% were also obtained. However, the presence of outliers which are tweets not related to COVID but which used the hashtag was observed.

Conclusion
This study has revealed the strength of BiLSTM deep learning technique for sentiment analysis. The results obtained revealed an almost balanced sentiments toward the pandemic with 49.93% positive disposition to the pandemic as compared to 50.06% negative disposition. This showed affirmed the impact of COVID vaccine in dousing citizen’s tension when it was made available for public use. However, the presence of outliers in the classified tweets could be a pointer to the reason why aspect-based sentiment analysis could be preferred to sentence-based sentiment analysis.
Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study
Authors: Živković Valentina , Cvetković Tatjana , Dinić Biljana Radovanović , Jurišić Vladimir 
Published: November 2023

Abstract
Background
The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-nucleosome and anti-C1q antibodies, and serum and urinary monocyte-chemoattractant protein-1 (MCP-1) with disease activity in patients with systemic lupus erythematosus (SLE).

Results
This study included 160 patients (145 female and 15 male patients), hospitalized at the Rheumatology Department. A positive correlation between NLR and ESR (p < 0.01), anti-dsDNA antibodies (p < 0.05), and PLR (p < 0.001) was obtained, with a negative correlation with C3 (p < 0.005). PLR shows a positive correlation with ESR (p < 0.001), CRP (p < 0.005), anti-dsDNA antibodies (p < 0.001), anti-nucleosome antibodies (p < 0.05), and urine MCP-1 (p < 0.05), with a negative correlation with C3 (p < 0.005). Univariate analysis showed that all the examined laboratory parameters were independent predictors of disease activity (p < 0.001), while the method of standard multiple regression analysis revealed the most significant ESR and serum MCP-1 (p < 0.05).

Conclusions
NLR and PLR, as inexpensive and accessible biomarkers, can help in routine clinical practice for the estimation of disease activity in SLE patients.
Assessing the early returns of robotic-assisted bronchoscopy in a patient population at high risk for cancer: factors associated with a diagnostic procedure and pathologic outcomes
Authors: Naaman Rami , Kapp Christopher M. , David Odile , Kovitz Kevin , Aronson Benjamin , Haas Kevin 
Published: November 2023

Abstract
Background
Lung cancer remains the most common cause of cancer-related deaths in the USA. Successful implementation of lung cancer screening programs has led to increased detection of peripheral pulmonary lesions (PPL). Robotic-assisted bronchoscopy (RB) is a relatively novel tool used to safely diagnose PPN. Additionally, with the developing precision of personalized medicine and targeted therapy, obtaining adequate tissue for next-generation sequencing (NGS) has become critical to optimizing the medical management of lung cancer. Our aim is to assess the diagnostic yield of RB, identify patient and procedure characteristics associated with performing a diagnostic biopsy, and evaluate the adequacy of tumor cellularity for biomarker identification.

Results
We performed a retrospective observational study consecutively enrolling 54 adult patients who underwent RB between January 2022 and March 2023. Records were reviewed for medical comorbidities and smoking status. PPL characteristics included size, location, presence of a bronchus sign on mapping computed tomography (CT) scans, distance from airway and pleura on CT, and days between obtaining CT and the bronchoscopy. Procedural factors included the radial endobronchial ultrasound (r-EBUS) view obtained and the sampling method(s) with which a diagnosis was achieved. Records were reviewed for final pathology and the need for further procedures to establish a diagnosis. Samples that yielded non-small cell lung cancer (NSCLC) were sent for an NGS panel if deemed adequate. The panels were reviewed to identify potentially actionable mutations. Multivariable logistic regression was performed to assess patients and lesions characteristics associated with a diagnostic biopsy. We sampled 56 lesions, 45 (80.4%) were from current or former smokers. The overall diagnostic yield was 73.2% and 68.9% for nodules less than 3 cm. Lesions size ranged from 8 mm nodules to 70 mm masses, with an average size 20.3 mm. Mean nodule size from diagnostic procedures was 21.5 mm and 16.9 mm from non-diagnostic ones (p = 0.04). Logistic regression analysis showed that the presence of a bronchus sign was associated with a diagnostic procedure (OR 19.4, p = 0.023), while lack of a r-EBUS view predicted a non-diagnostic bronchoscopy (OR 0.02, p = 0.013). 28 diagnostic biopsies (68.3%) yielded NSCLC and of the 25 cases that we followed, 22 samples (88%) were adequate for NGS.

Conclusions
The presence of a bronchus sign on CT and obtaining r-EBUS view during RB were associated with a higher diagnostic yield. RB successfully sampled PPL with adequate tumor cellularity for NGS.
Early intervention in psychosis services: A systematic review and narrative synthesis of barriers and facilitators to seeking access
Authors: Tiller Jacqui , Maguire Tess , Newman-Taylor Katherine 
Published: November 2023

Abstract

Background
The duration of untreated psychosis (DUP) continues to be a global priority. Early intervention services were established to reduce treatment delays but have had limited impact. This systematic review examines barriers and facilitators to seeking access to these services, to identify targets for service level change.

Methods
We conducted a systematic review of relevant databases (PsychINFO, MEDLINE, CINAHL, and PsychARTICLES) using pre-defined search terms for psychosis, early intervention, and barriers and facilitators. Given the majority of qualitative studies, a thematic synthesis rather than meta-analysis was indicated.

Results
The search yielded 10 studies. Mental health stigma and discrimination predict DUP, compounded by structural barriers which limit the impact of early intervention services on timely access to recommended treatments. Synthesis of the qualitative studies generated three themes: knowledge, relationships, and stigma. Lack of knowledge, absence of supportive relationships (social and professional), and self-stigma constitute significant barriers to seeking access to early intervention services.

Conclusions
This is the first review of the barriers and facilitators to seeking access to early intervention services. The findings highlight public health and secondary care service targets to expedite access to recommended treatments and thereby reduce the DUP.
Overall Survival With Circulating Tumor Cell Count–Driven Choice of Therapy in Advanced Breast Cancer: A Randomized Trial
Authors: Bidard François-Clément , Kiavue Nicolas , Jacot William , Bachelot Thomas , Dureau Sylvain , Bourgeois Hugues , Goncalves Anthony , Brain Etienne , Ladoire Sylvain , Dalenc Florence , Gligorov Joseph , Teixeira Luis , Emile George , Ferrero Jean-Marc , Loirat Delphine , Cabel Luc , Kadi Amir , Diéras Véronique , Alix-Panabières Catherine , Pierga Jean-Yves 
Published: November 2023

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. In patients with hormone receptor–positive, human epidermal growth factor receptor 2–negative advanced breast cancer, the STIC CTC trial established that, for choosing between endocrine therapy (ET) or chemotherapy, the use of circulating tumor cell (CTC) count is noninferior to the investigator's choice in terms of progression-free survival. Here, we report overall survival (OS) results, a secondary end point. Patients were randomly assigned in a 1:1 ratio to have their first-line treatment (ET or chemotherapy) determined by investigators or CTC count (chemotherapy if ≥ 5 CTCs/7.5 mL; ET if low CTC count; CellSearch). OS was assessed at the discontinuation of follow-up. After a median follow-up of 4.7 years, 382 deaths (50.6%) had occurred among 755 patients. Median OS was 51.3 months (95% CI, 46.8 to 55.1) in the CTC arm and 45.5 months (95% CI, 40.9 to 51.1) in the standard arm (hazard ratio [HR] for death, 0.85; 95% CI, 0.69 to 1.03; P = .11). Among 189 patients (25.0%) with ET recommended by clinicians and high CTC count, chemotherapy was superior to ET (HR for death, 0.53; 95% CI, 0.36 to 0.78; P = .001). In case of a discordant estimate, OS data demonstrate the clinical utility of CTC count.
Impact of dysfunctional parenting, affective temperaments, and stressful life events on the development of melancholic and non-melancholic depression: A path analysis study
Authors: Tamada Yu , Inoue Takeshi , Sekine Atsushi , Toda Hiroyuki , Takeshima Minoru , Sasaki Masaaki , Fujimura Yota , Ohmae Susumu 
Published: November 2023

Background
The influence of psychosocial factors on differentiating between melancholic depression (MEL) and non-melancholic depression (NMEL) remains unclear. In this study, we aimed to investigate the interrelationship between dysfunctional parenting, personality traits, stressful life events, and the diagnosis of MEL and NMEL among patients with major depressive disorder (MDD).

Methods
Ninety-eight patients with MDD completed the following self-administered questionnaires: the Parental Bonding Instrument (PBI) for dysfunctional parenting, the short version of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) for affective temperaments, and the Life Experiences Survey (LES) for stressful life events. The data were analyzed using single and multiple regression analyses and path analysis.

Results
Dysfunctional parenting did not have a significant direct effect on MEL. However, paternal care had a significant indirect effect on MEL through depressive temperament. The total indirect effect of paternal care on MEL was significant (indirect path coefficient = 0.161, p <0.05). In other words, low levels of paternal care were associated with the development of NMEL via increased depressive temperament. None of the paths from paternal care to MEL via negative change scores of the LES were significant.

Limitations
This study used cross-sectional data, so the possibility that current depressive status may affect the assessment of LES and TEMPS-A cannot be ruled out.

Conclusions
We found that low levels of paternal care did not directly affect the development of NMEL, but affected the development of NMEL through the mediation of depressive temperament rather than stressful life events.
Qualidade de Vida no Ambiente de Trabalho: Implementação e Desafios
Authors: Oliveira Rodrigues Vinícius , Sales Silva Rogerio 
Published: November 2023

A implementação da qualidade de vida, e também de trabalho, se constituiu nesses últimos tempos em meio a globalização, a redução dos afastamentos por conta de presenteísmo e do absenteísmo, bem como de doenças relacionadas ao LER/DORT. Além disso, a implementação de programas de qualidade de vida no ambiente de trabalho (PQVT) tinham também como objetivo o aumento da produtividade, e o equilíbrio entre as demandas da empresa e dos colaboradores. A partir desse contexto, a presente pesquisa teve como objetivo descrever a ergonomia e sua relação com a qualidade de vida no trabalho. Com relação aos resultados, foi observado que a implementação da qualidade de vida depende diretamente da cultura organizacional, do apoio da alta gerência, e de investimentos por parte da empresa na implementação do PQVT. Concluiu-se que a criação de programas de qualidade de vida no ambiente de trabalho podem trazer uma melhoria da produtividade, diminuindo o absenteísmo laboral, o que por sua vez pode implicar em na melhoria dos resultados organizacionais.