bluuebunny/crossref_metadata_2025_split huggingface dataset:
A possible production area of Chinese faience? Reference to beads decorating coffins from Shijia Yucun site, Gansu Province
Authors: Cao Shiyuan , Wang Yongan , Wen Rui , Sun Feng , Ren Yubo 
Published: January 2024

AbstractShijia Yucun site is a northwestern settlement from the Zhou period (1046–221 BCE). Faience beads used as a personal ornament and coffin decoration are notable among plenty of funerary objects. Thirteen faience objects are determined using analytical electron probe micro‐analysis (EPMA) and scanning electron microscopy‐energy dispersive X‐ray spectroscopy (SEM–EDS). The information on their provenance indicates that the types of faience beads around bodies include the mixed‐alkali faience from Europe or the Eurasian Steppe, the soda‐enriched faience from West Asia, and the local products rich in potash. However, faience samples adorning coffins are all local products, and the quality is rougher compared to the faience decorating the body. This unique feature is hardly found in other tombs of Zhou elites. As faience was a precious personal ornament in other stronger polities, it was already available as a general coffin decoration in such a small‐economy feudal state, so faience samples decorating coffins were not likely to be precious gifts from other elites. It is reasonable to assume that faience beads adorning coffins might have been made near the ruins. This investigation is significant to reveal the cultural exchange in the western frontier of the Zhou realm that dates back to the power decline of the Western Zhou period and highlight a possible high‐potash faience production area.
Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR
Authors: Xi Sujuan , Ding Wei , Weng Danping , Zeng Yue , Gao Kewei , Wu Qiuye , Huang Guoping , Li Yufang , Yue Haiyan 
Published: January 2024

AbstractProgrammed cell death (PCD) induction is a promising strategy for killing gastric cancer cells. In this study, we investigated the effects of chrysophanol on apoptosis and ferroptosis in gastric cancer cells. Chrysophanol in concentrations ranging from 0 to 100 μM were used to treat GES‐1, HGC‐27 and AGS cells. Cell counting kit‐8 assay, colony formation assay, 5‐ethynyl‐2′‐deoxyuridine staining, flow cytometry, JC‐1 probe insertion, dihydroethidium staining and western blotting were performed. The effects of chrysophanol on gastric cancer cells were evaluated in vivo using a xenograft mouse model. Chrysophanol had no cytotoxic effects on GES‐1 cells. Chrysophanol with concentrations higher than 25 μM inhibited gastric cancer cell colony formation and proliferation. Chrysophanol induces gastric cancer cell apoptosis in a dose‐dependent manner, accompanied by mitochondrial membrane potential dysfunction and cytochrome c release. Additionally, chrysophanol increased the levels of reactive oxygen species, total iron, and Fe2+ in HGC‐27 and AGS cells, in a dose‐dependent manner. Treatment of cells with the ferroptosis inhibitor ferrostatin‐1 attenuated the effects of chrysophanol on cell survival and the expression of ferroptosis markers SLC7A11 and GPX4. Screening by GEO software indicated that the mTOR signalling pathway is possibly regulated by chrysophanol. Furthermore, mTOR overexpression significantly reversed the inhibitory effects of chrysophanol on gastric cancer cells. In gastric cancer xenograft mouse models, chrysophanol treatment inhibited tumour growth and downregulated SLC7A11 and GPX4. Chrysophanol induces apoptosis and ferroptosis, making it a potential candidate for killing gastric cancer cells. The beneficial effects of chrysophanol may be attribute to the targeted regulation of mTOR.
School victimization and psychosocial adjustment among Eastern European adopted adolescents across Europe
Authors: Cáceres Isabel , Palacios Jesús , Ferrari Laura , Ranieri Sonia , Rosnati Rosa , Miller Laurie C. , Theie Steinar , Carrera Pablo , de Montclos Marie‐Odile Pérouse , Román Maite 
Published: January 2024

AbstractBackgroundLittle is known about bullying experienced by internationally adopted teens residing in Europe.ObjectivesWithin the framework of an international research effort involving several European countries, the main goal of this study was to explore the experiences of bullying victimization suffered by adopted adolescents, as well as its impact on their psychological adjustment.MethodsThe sample consisted of 199 adolescents born in Eastern European countries and adopted in France (n = 50), Italy (n = 59), Norway (n = 25) and Spain (n = 65).ResultsMore than half of the adopted adolescents had been exposed to some form of peer victimization in the previous 2 months, with verbal harassment and social exclusion being the most common forms of victimization. Differences between receiving countries were not statistically significant, suggesting a common pattern for Eastern European adopted adolescents living in Western Europe. More frequent experiences of peer victimization were associated with more psychological difficulties among the adopted adolescents.ConclusionsFindings highlight that adopted adolescents might have considerable difficulties in social integration with peers; these experiences of peer victimization might play an important role hindering their psychosocial adjustment. The socioemotional development of adopted people is not only linked to their pre‐adoptive experiences; factors in their daily lives (i.e., peer relationships) may also be associated with their psychological adjustment later in life. Interventions are needed to promote the real inclusion of these groups of children in their social and educational contexts.
Behaviour change intervention for toothbrushing (lesson and text messages) to prevent dental caries in secondary school pupils: The BRIGHT randomized control trial
Authors: Innes Nicola , Fairhurst Caroline , Whiteside Katie , Ainsworth Hannah , Sykes Debbie , El Yousfi Sarab , Turner Emma , Chestnutt Ivor G. , Keetharuth Anju , Dixon Simon , Day Peter F. , Seifo Nassar , Gilchrist Fiona , Hicks Katie , Kellar Ian , Al‐Yaseen Waraf , Araujo Mariana , Dey Donna , Hewitt Catherine , Pavitt Sue , Robertson Mark , Torgerson David , Marshman Zoe 
Published: January 2024

AbstractObjectivesThis multicentre, assessor‐blinded, two‐arm cluster randomized trial evaluated the clinical and cost‐effectiveness of a behaviour change intervention promoting toothbrushing for preventing dental caries in UK secondary schools.MethodsPupils aged 11–13 years with their own mobile telephone attending secondary schools with above average free school meals eligibility were randomized (at year‐group level) to receive a lesson and twice‐daily text messages or to usual care. Year‐groups (n = 84) from 42 schools including 4680 pupils (intervention, n = 2262; control, n = 2418) were randomized.ResultsIn 2383 participants with valid data at baseline and 2.5 years, the primary outcome of presence of at least one treated or untreated carious lesion (D4‐6 MFT [Decayed, Missing and Filled Teeth] in permanent teeth using International Caries Detection and Assessment System) was 44.6% in the intervention group and 43.0% in control (odds ratio [OR] 1.04, 95% CI 0.85–1.26, p = .72). There were no statistically significant differences in secondary outcomes of presence of at least one treated or untreated carious lesion (D1‐6 MFT), number of D4‐6 MFT and D1‐6 MFT, plaque and bleeding scores or health‐related‐ (Child Health Utility 9D) or oral health‐related‐ quality of life (CARIES‐QC). However, twice‐daily toothbrushing, reported by 77.6% of pupils at baseline, increased at 6 months (intervention, 86.9%; control, 83.0%; OR 1.30, 95% CI 1.03–1.63, p = .03), but returned to no difference at 2.5 years (intervention, 81.0%; control, 79.9%; OR 1.05, 95% CI 0.84–1.30, p = .69). Estimated incremental costs and quality‐adjusted life‐years (QALYs) of the intervention, relative to control, were £1.02 (95% CI −1.29 to 3.23) and −0.003 (95% CI −0.009 to 0.002), respectively, with a 7% chance of being cost‐effective (£20 000/QALY gained threshold).ConclusionThere was no evidence of statistically significant difference for caries prevalence at 2.5‐years. The intervention's positive 6‐month toothbrushing behaviour change did not translate into caries reduction. (ISRCTN 12139369). COVID‐19 pandemic adversly affected follow‐up.
Glycolysis: An early marker for vancomycin‐specific T‐cell activation
Authors: Gardner Joshua , Hammond Sean , Jensen Rebecca , Gibson Andrew , Krantz Matthew S. , Ardern‐Jones Michael , Phillips Elizabeth J. , Pirmohamed Munir , Chadwick Amy E. , Betts Catherine , Naisbitt Dean J. 
Published: January 2024

AbstractBackgroundVancomycin, a glycopeptide antibiotic used for Gram‐positive bacterial infections, has been linked with drug reaction with eosinophilia and systemic symptoms (DRESS) in HLA‐A*32:01‐expressing individuals. This is associated with activation of T lymphocytes, for which glycolysis has been isolated as a fuel pathway following antigenic stimulation. However, the metabolic processes that underpin drug‐reactive T‐cell activation are currently undefined and may shed light on the energetic conditions needed for the elicitation of drug hypersensitivity or tolerogenic pathways. Here, we sought to characterise the immunological and metabolic pathways involved in drug‐specific T‐cell activation within the context of DRESS pathogenesis using vancomycin as model compound and drug‐reactive T‐cell clones (TCCs) generated from healthy donors and vancomycin‐hypersensitive patients.MethodsCD4+ and CD8+ vancomycin‐responsive TCCs were generated by serial dilution. The Seahorse XFe96 Analyzer was used to measure the extracellular acidification rate (ECAR) as an indicator of glycolytic function. Additionally, T‐cell proliferation and cytokine release (IFN‐γ) assay were utilised to correlate the bioenergetic characteristics of T‐cell activation with in vitro assays.ResultsModel T‐cell stimulants induced non‐specific T‐cell activation, characterised by immediate augmentation of ECAR and rate of ATP production (JATPglyc). There was a dose‐dependent and drug‐specific glycolytic shift when vancomycin‐reactive TCCs were exposed to the drug. Vancomycin‐reactive TCCs did not exhibit T‐cell cross‐reactivity with structurally similar compounds within proliferative and cytokine readouts. However, cross‐reactivity was observed when analysing energetic responses; TCCs with prior specificity for vancomycin were also found to exhibit glycolytic switching after exposure to teicoplanin. Glycolytic activation of TCC was HLA restricted, as exposure to HLA blockade attenuated the glycolytic induction.ConclusionThese studies describe the glycolytic shift of CD4+ and CD8+ T cells following vancomycin exposure. Since similar glycolytic switching is observed with teicoplanin, which did not activate T cells, it is possible the master switch for T‐cell activation is located upstream of metabolic signalling.
Does Lexical Coordination Affect Epistemic and Practical Trust? The Role of Conceptual Pacts
Authors: Pozzi Mélinda , Bangerter Adrian , Mazzarella Diana 
Published: January 2024

AbstractThe present study investigated whether humans are more likely to trust people who are coordinated with them. We examined a well‐known type of linguistic coordination, lexical entrainment, typically involving the elaboration of “conceptual pacts,” or partner‐specific agreements on how to conceptualize objects. In two experiments, we manipulated lexical entrainment in a referential communication task and measured the effect of this manipulation on epistemic and practical trust. Our results showed that participants were more likely to trust a coordinated partner than an uncoordinated one, but only when the latter broke previously established conceptual pacts.
Cardiopulmonary progenitors facilitate cardiac repair via exosomal transfer of miR‐27b‐3p targeting the SIK1‐CREB1 axis
Authors: Xiao Ying‐Ying , Xia Luo‐Xing , Jiang Wen‐Jing , Qin Jian‐Feng , Zhao Li‐Xin , Li Zhan , Huang Li‐Juan , Li Ke‐Xin , Yu Peng‐Jiu , Wei Li , Jiang Xue‐Yan , Chen Zhe‐Sheng , Yu Xi‐Yong 
Published: January 2024

AbstractIschemic heart disease, especially myocardial infarction (MI), is one of the leading causes of death worldwide, and desperately needs effective treatments, such as cell therapy. Cardiopulmonary progenitors (CPPs) are stem cells for both heart and lung, but their repairing role in damaged heart is still unknown. Here, we obtained CPPs from E9.5 mouse embryos, maintained their stemness while expanding, and identified their characteristics by scRNA‐seq, flow cytometry, quantitative reverse transcription‐polymerase chain reaction, and differentiation assays. Moreover, we employed mouse MI model to investigate whether CPPs could repair the injured heart. Our data identified that CPPs exhibit hybrid fibroblastic, endothelial, and mesenchymal state, and they could differentiate into cell lineages within the cardiopulmonary system. Moreover, intramyocardial injection of CPPs improves cardiac function through CPPs exosomes (CPPs‐Exo) by promotion of cardiomyocytic proliferation and vascularization. To uncover the underlying mechanism, we used miRNA‐seq, bulk RNA‐seq, and bioinformatic approaches, and found the highly expressed miR‐27b‐3p in CPPs‐Exo and its target gene Sik1, which can influence the transcriptional activity of CREB1. Therefore, we postulate that CPPs facilitate cardiac repair partially through the SIK1‐CREB1 axis via exosomal miR‐27b‐3p. Our study offers a novel insight into the role of CPPs‐Exo in heart repair and highlights the potential of CPPs‐Exo as a promising therapeutic strategy for MI.
Mouse islet‐derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function
Authors: Xu Wei , Zhou Yunting , Wang Tianyuan , Ni Chengming , Wang Chunlei , Li Rui , Liu Xuekui , Liang Jun , Hong Tzu‐wen , Liu Bo , King Aileen J. F. , Persaud Shanta J. , Sun Zilin , Jones Peter M. 
Published: January 2024

AbstractAimsEvidence is accumulating of the therapeutic benefits of mesenchymal stromal cells (MSCs) in diabetes‐related conditions. We have identified a novel population of stromal cells within islets of Langerhans – islet stellate cells (ISCs) – which have a similar morphology to MSCs. In this study we characterize mouse ISCs and compare their morphology and function to MSCs to determine whether ISCs may also have therapeutic potential in diabetes.MethodsISCs isolated from mouse islets were compared to mouse bone marrow MSCs by analysis of cell morphology; expression of cell‐surface markers and extracellular matrix (ECM) components; proliferation; apoptosis; paracrine activity; and differentiation into adipocytes, chondrocytes and osteocytes. We also assessed the effects of co‐culture with ISCs or MSCs on the insulin secretory capacity of islet beta cells.ResultsAlthough morphological similar, ISCs were functionally distinct from MSCs. Thus, ISCs were less proliferative and more apoptotic; they had different expression levels of important paracrine factors; and they were less efficient at differentiation down multiple lineages. Co‐culture of mouse islets with ISCs enhanced glucose induced insulin secretion more effectively than co‐culture with MSCs.ConclusionsISCs are a specific sub‐type of islet‐derived stromal cells that possess biological behaviors distinct from MSCs. The enhanced beneficial effects of ISCs on islet beta cell function suggests that they may offer a therapeutic target for enhancing beta cell functional survival in diabetes.
Criminality in patients with autoimmune encephalitis: A case series
Authors: Michael Sophia , Varley James , Williams Robyn , Bajorek Tomasz , Easton Ava , Irani Sarosh R. 
Published: January 2024

AbstractBackground and purposeDespite it being an immunotherapy‐responsive neurological syndrome, patients with autoimmune encephalitis (AE) frequently exhibit residual neurobehavioural features. Here, we report criminal behaviours as a serious and novel postencephalitic association.MethodsThis retrospective cohort study included 301 AE patients. Five of who committed crimes underwent direct assessments and records review alongside autoantibody studies.ResultsFive of 301 patients (1.7%) with AE exhibited criminal behaviours, which included viewing child pornography (n = 3), repeated shoplifting, and conspiracy to commit murder. All five were adult males, with LGI1 autoantibodies (n = 3), CASPR2 autoantibodies, or seronegative AE. None had evidence of premorbid antisocial personality traits or psychiatric disorders. Criminal behaviours began a median of 18 months (range = 15 months–12 years) after encephalitis onset. At the time of crimes, two patients were immunotherapy‐naïve, three had been administered late immunotherapies (at 5 weeks–4 months), many neurobehavioural features persisted, and new obsessive behaviours had appeared. However, cognition, seizure, and disability measures had improved, alongside reduced autoantibody levels.ConclusionsCriminal behaviours are a rare, novel, and stigmatizing residual neurobehavioural phenotype in AE, with significant social and legal implications. With caution towards overattribution, we suggest they occur as part of a postencephalitis limbic neurobehavioural syndrome.
The cost of crossing gender boundaries: Trans women of color and the racialized workplace gender order
Authors: Greene Joss , Ervin Woods 
Published: January 2024

AbstractHow does persistent and cumulative gender regulation produce economic insecurity? Trans people face markedly high levels of workplace discrimination, unemployment, and poverty, and therefore offer unique insight into this question. Prior research theorizes how trans workers get repositioned in a binary, patriarchal gender order, but we lack a conceptual model to explain the labor market experience of people who are systematically sanctioned as gender deviants. By analyzing work history interviews from 23 trans women of color based across the United States, this article argues that crossing gender boundaries is a racialized experience that can come with an economic cost. After transitioning, trans women of color face three forms of economic sanctioning: exclusion, a racially gendered glass ceiling, and constrained employment options within a segmented labor market. Thus, work organizations premised on a hierarchical classification scheme have the option, not only to reposition people on the basis of a classification change, but to deem them unassimilable.
Effect of PyC/BN interfacial phases on mechanical behavior of SiC/SiC composites
Authors: Qiu Haipeng , Zhang Qiyue , Luo Wendong , Xie Weijie , Ma Xin , Zhang Bingyu , Chen Yi , Chen Mingwei 
Published: January 2024

AbstractPyC/BN multiphase interfacial phases were prepared on the surface of SiC fiber preform, then the near stoichiometric ratio SiC fiber reinforced SiC ceramic matrix composites were obtained by polymer impregnation and pyrolysis (PIP) process. The mechanical behavior of SiC/SiC composites was characterized by three‐point bending tests and fracture toughness tests. The stress release and load transfer effects of the interfaces under external loads were analyzed by scanning electron microscope (SEM). Results showed that with the increasing of PyC component thickness from .10 to.30 µm in the PyC/BN multiphase interfacial phases, the bending strength and fracture toughness both increased first and then decreased. The results occurred due to the competition between load transfer and stress release of the interfaces. The relatively optimized interfacial phase structure was that the thickness of the PyC interfacial phase and BN interfacial phase were .20 and.30 µm. The bending strength and fracture toughness of the optimized SiC/SiC composites reached 660.65 MPa and 29.01 MPa•m1/2. Respectively, many matrix cracks appeared in the horizontal and vertical directions, occupying almost the entire fracture section. The growth path of the matrix crack was significantly increased with many long fibers pulled out and broken, which was conducive to the strengthening and toughening of SiC/SiC composites.
The relationship between self‐regulated learning strategy use and task engagement
Authors: Zare Javad , Delavar Khadijeh Aqajani , Derakhshan Ali , Pawlak Mirosław 
Published: January 2024

AbstractDrawing on the explanatory sequential mixed‐methods design, the present study aims to investigate the relationship, if any, between self‐regulated learning (SRL) strategy use and task engagement. The participants of the study were 361 Iranian EFL students majoring in English language teaching or English language and literature for the B.A. degree, with a B1 English language proficiency level, based on the Common European Framework of Reference for Languages. Questionnaire surveys, narrative frames, and semi‐structured interviews were used to collect the data remotely during the COVID‐19 pandemic. The results of quantitative data analysis showed that SRL strategy use is a significant predictor of task engagement. The results of the qualitative analysis also pointed to the importance of SRL strategies, including (meta)cognitive, (meta)affective, (meta)motivational, and (meta)social strategies, to maintain task engagement. The results of the study may be used to inform English language teachers, learners, materials developers, and measurement instrument developers.
Two inclusion complexes of cinnamon essential oil and lemongrass essential oil with β‐CD: preparation, characterisation and effect on the preservation of mango fruits
Authors: Phan Chiuyen , Do Thithuyvan , Thuong Thikimphuong 
Published: January 2024

SummaryMango is a nutritious fruit but susceptible to the development of black spots on its skin, which can significantly reduce the post‐harvest fruit quality. In response to this challenge, this study focused on preparing and characterising two inclusion complexes (ICs) by combining cinnamon essential oil (CEO) and lemongrass essential oil (LEO) with β‐cyclodextrin (β‐CD), named CEO‐β‐CD and LEO‐β‐CD. Their effectiveness in preserving mango fruit were evaluated. The findings demonstrated the successful encapsulation of essential oils by β‐CD, forming two distinct ICs. Moreover, these ICs notably extended the shelf‐life of mangoes by 40% and 25%, respectively, while reducing black spot occurrence on the fruit skin. Additionally, analysis of physicochemical parameters revealed that the CEO‐β‐CD IC, at a dosage of 2.5 mg per gram of mango, could notably enhance the overall fruit quality. In conclusion, the application of CEO‐β‐CD, at an appropriate concentration, exhibits promising potential as an effective preservative for mangoes.