bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of surgical randomised controlled trials on the management of FAI syndrome: a citation analysis
Authors: Abdel Khalik Hassaan , Lameire Darius L. , Park Lily J. , Ayeni Olufemi R. 
Published: October 2023

AbstractPurposeTo identify and assess the clinical impact of randomised controlled trials (RCTs) assessing the surgical management of femoroacetabular impingement syndrome (FAIS) through a citation analysis.MethodsMEDLINE, EMBASE and CENTRAL were searched from inception to April 22, 2023 for RCTs assessing the surgical management of FAIS. Study characteristics were directly abstracted from included trials and citation metrics were obtained from the Clarivate Web of Knowledge database on May 19, 2023. The continuous fragility index (CFI) was calculated for eligible outcomes. Univariate regression models were used to explore correlations between total citations per year and various study characteristics.ResultsTen studies comprising one thousand two hundred ninetypatients were eligible for analysis. Studies were published from 2013 to 2023. Eight countries were represented across various trials with 91% being either North American or European. The mean journal impact factor of published studies was 39.684 (median 2.982; range 1.31–202.73). The mean citation density was 14.17 (range 0.33–48.67). The median CFI was 4.8 (range 1–32.2). Correlation analysis demonstrated strong and statistically significant correlations to study sample size (R = 0.75, p = 0.012), journal impact factor (R = 0.80, p = 0.006) and continuous fragility index (R = 0.95, p = 0.015).ConclusionTrials assessing the surgical management of FAIS present with a wide range of clinical uptake based on citation density and are published in journals of broadly variable impact factor. Despite promising citation metrics, high‐quality evidence on arthroscopy for FAIS is limited to the United States and Europe with an unclear international impact. Future knowledge translation efforts are warranted to maximise the international uptake of evidence regarding arthroscopic management of FAIS.Level of evidenceI.
A photobioreactor for production of algae biomass from gaseous emissions of an animal house
Authors: Glockow Till , Velaz Martín Marta , Meisch Laura , Kapieske Denis , Meissner Kai , Correa Cassal Maximiano , Kaster Anne-Kristin , Rabe Kersten S. , Niemeyer Christof M. 
Published: October 2023

Abstract
Sustainable approaches to circular economy in animal agriculture are still poorly developed. Here, we report an approach to reduce gaseous emissions of CO2 and NH3 from animal housing while simultaneously using them to produce value-added biomass. To this end, a cone-shaped, helical photobioreactor was developed that can be integrated into animal housing by being freely suspended, thereby combining a small footprint with a physically robust design. The photobioreactor was coupled with the exhaust air of a chicken house to allow continuous cultivation of a mixed culture of Arthrospira spec. (Spirulina). Continuous quantification of CO2 and NH3 concentration showed that the coupled algae reactor effectively purifies the exhaust air from the chicken house while producing algal biomass. Typical production rates of greater than 0.3 g/l*day dry mass were obtained, and continuous operation was possible for several weeks. Morphological, biochemical, and genomic characterization of Spirulina cultures yielded insights into the dynamics and metabolic processes of the microbial community. We anticipate that further optimization of this approach will provide new opportunities for the generation of value-added products from gaseous CO2 and NH3 waste emissions, linking resource-efficient production of microalgae with simultaneous sequestration of animal emissions.

Key points
• Coupling a bioreactor with exhaust gases of chicken coop for production of biomass.
• Spirulina mixed culture removes CO2 and NH3 from chicken house emissions.
• High growth rates and biodiversity adaptation for nitrogen metabolism.

Graphical abstract
Towards a sustainable circular economy in livestock farming. The functional coupling of a helical tube photobioreactor with exhaust air from a chicken house enabled the efficient cultivation of Spirulina microalgae while simultaneously sequestering the animals’ CO2 and NH3 emissions.
Acute appendicitis in children: is preoperative hyponatremia a predictive factor of perforation/gangrene? A prospective study
Authors: Elgendy Ahmed , Khirallah Mohammad Gharieb , Elsawaf Mohamed , Hassan Hussam S. , Ghazaly Mohamed 
Published: October 2023

Abstract
Purpose
Distinguishing between perforated/gangrenous from uncomplicated appendicitis in children helps management. We evaluated hyponatremia as a new diagnostic marker for perforated/gangrenous appendicitis in children.

Methods
A prospective study including all children with acute appendicitis who underwent appendectomy at our institution from May 2021 to May 2023. Medical history and clinical criteria were analyzed. All blood samples were taken upon admission including serum inflammatory markers and electrolytes. Patients were divided into two groups (Group I: uncomplicated and Group II: perforated/gangrenous), and data between both groups were compared.

Results
The study included 153 patients [Group I: 111 (73%), Group II: 42 (27%)]. Mean serum sodium concentration in children with perforated/gangrenous appendicitis was significantly lower compared to children with uncomplicated appendicitis (131.8 mmol/L vs. 138.7 mmol/L; p < 0.001). The ROC curve of preoperative sodium level to differentiate between perforated/gangrenous and uncomplicated appendicitis revealed an AUC of 0.981. The cut-off-value of sodium level < 135 mmol/L identified perforated/gangrenous appendicitis with a sensitivity of 94% and a specificity of 91% (p < 0.001). Predictive factors of perforated/gangrenous appendicitis were: age less than 5 years (12% vs. 3%; p = 0.02), experiencing symptoms for more than 24 h (100% vs. 58%; p < 0.001), body temperature more than 38.5 °C (52% vs. 13%; p < 0.001), a serum sodium level less than 135 mmol/L (90% vs. 6%; p < 0.001), and a CRP serum level more than 50 mg/L (71% vs. 17%; p < 0.001).

Conclusions
Hyponatremia, upon admission, is a novel, objective biochemical marker that can identify perforated/gangrenous appendicitis in children. We advocate that the assessment of serum sodium level should be added to the diagnostic algorithm in children with suspected acute appendicitis. Surgical intervention in patients with hyponatremia should not be delayed, and non-operative management should be avoided.
Use of patient-derived explants as a preclinical model for precision medicine in colorectal cancer: A scoping review
Authors: Mui Milton , Clark Molly , Vu Tamara M. S. H. , Clemons Nicholas , Hollande Frédéric , Roth Sara , Ramsay Robert , Michael Michael , Heriot Alexander G. , Kong Joseph C. H. 
Published: October 2023

Abstract
Purpose
Whilst the treatment paradigm for colorectal cancer has evolved significantly over time, there is still a lack of reliable biomarkers of treatment response. Treatment decisions are based on high-risk features such as advanced TNM stage and histology. The role of the tumour microenvironment, which can influence tumour progression and treatment response, has generated considerable interest. Patient-derived explant cultures allow preservation of native tissue architecture and tumour microenvironment. The aim of the scoping review is to evaluate the utility of patient-derived explant cultures as a preclinical model in colorectal cancer.

Methods
A search was conducted using Ovid MEDLINE, EMBASE, Web of Science, and Cochrane databases from start of database records to September 1, 2022. We included all peer-reviewed human studies in English language which used patient-derived explants as a preclinical model in primary colorectal cancer. Eligible studies were grouped into the following categories: assessing model feasibility; exploring tumour microenvironment; assessing ex vivo drug responses; discovering and validating biomarkers.

Results
A total of 60 studies were eligible. Fourteen studies demonstrated feasibility of using patient-derived explants as a preclinical model. Ten studies explored the tumour microenvironment. Thirty-eight studies assessed ex vivo drug responses of chemotherapy agents and targeted therapies. Twenty-four studies identified potential biomarkers of treatment response.

Conclusions
Given the preservation of tumour microenvironment and tumour heterogeneity, patient-derived explants has the potential to identify reliable biomarkers, treatment resistance mechanisms, and novel therapeutic agents. Further validation studies are required to characterise, refine and standardise this preclinical model before it can become a part of precision medicine in colorectal cancer.
Contributing and limiting factors to guideline-adherent therapy in senior and elderly breast cancer patients: a questionnaire-based cross-sectional study using clinical and cancer registry data in Germany
Authors: Heidenreich Andreas , Fuchshofen Rabea , Elsner Susanne , Gieseler Frank , Katalinic Alexander , Hübner Joachim 
Published: October 2023

Abstract
Purpose
Elderly cancer patients are less likely to be treated in accordance with evidence-based guideline recommendations. This study examines patient-related factors associated with deviations from guideline recommendations.

Methods
Using medical documentation and cancer registry data, we investigated the treatment courses of female breast cancer patients aged 50 and older in Germany regarding compliance with German guidelines. Participants completed a questionnaire querying factors hypothesized to be associated with guideline adherence. We conducted univariate analyses to explore the data and select variables for multivariate logistic regression to estimate adjusted odds ratios.

Results
Of 1150 participants, 206 (17.9%) were treated in deviation from guideline recommendations. Patients 70 years and older were more likely to be treated deviating from guideline recommendations than patients 50–69 years old (OR: 2.07; 95% CI: 1.52–2.80). Patients aged 50–69 years who reported that quality of life guided their treatment decision were more likely to be treated in deviation from guideline recommendations (AOR: 2.08; 95% CI: 1.11–3.92) than the elderly. In older patients, higher age was associated with an increased chance of receiving guideline-discordant care (AOR: 1.06; 95% CI: 1.01–1.11), as was depression diagnosed prior to cancer (AOR: 1.84; 95% CI: 1.00–3.40).

Conclusion
Reasons for deviations from guideline recommendations in breast cancer patients differ by age. In decision-making concerning elderly patients, particular attention should be paid to those with pre-existing depressive disorders. Adequately addressing their needs and concerns could prevent inappropriate deviations from guideline recommendations.
The importance of patch shape at threshold occupancy: functional patch size within total habitat amount
Authors: Keller Jeffrey K. , Sullivan Patrick J. 
Published: October 2023

AbstractThe habitat amount hypothesis (HAH) stresses the importance of total patch amount over the size of individual patches in determining species richness within a local landscape. However, the absence of some species from patches too small to contain a territory would be inconsistent with the HAH. Using the association of territory size with body size and the circle as optimal territory shape, we tested several HAH predictions of threshold patch occupancy and richness of 19 guilds of primarily insectivorous breeding birds. We characterized 16 guild-associated patch types at high spatial resolution and assigned one type to each guild. We measured functional patch size as the largest circle that fit within each patch type occurring in a local landscape. Functional patch size was the sole or primary predictor in regression models of species richness for 15 of the 19 guilds. Total patch amount was the sole or primary variable in only 2 models. Quantifying patch size at high resolution also demonstrated that breeding birds should be absent from patches that are too small to contain a territory and larger species should occur only in larger patches. Functional patch size is a readily interpretable metric that helps explain the habitat basis for differences in species composition and richness between areas. It provides a tool to assess the combined effects of patch size, shape and perforation on threshold habitat availability, and with total patch amount can inform design and/or evaluation of conservation, restoration or enhancement options for focal taxa or biodiversity in general.
Randomized Strategies for Robust Combinatorial Optimization with Approximate Separation
Authors: Kawase Yasushi , Sumita Hanna 
Published: October 2023

AbstractIn this paper, we study the following robust optimization problem. Given a set family representing feasibility and candidate objective functions, we choose a feasible set, and then an adversary chooses one objective function, knowing our choice. The goal is to find a randomized strategy (i.e., a probability distribution over the feasible sets) that maximizes the expected objective value in the worst case. This problem is fundamental in wide areas such as artificial intelligence, machine learning, game theory, and optimization. To solve the problem, we provide a general framework based on the dual linear programming problem. In the framework, we utilize the ellipsoid algorithm with the approximate separation algorithm. We prove that there exists an $$\alpha $$
α
-approximation algorithm for our robust optimization problem if there exists an $$\alpha $$
α
-approximation algorithm for finding a (deterministic) feasible set that maximizes a nonnegative linear combination of the candidate objective functions. Using our result, we provide approximation algorithms for the max–min fair randomized allocation problem and the maximum cardinality robustness problem with a knapsack constraint.
Practical Concepts for Design, Construction and Application of Halbach Magnets in Magnetic Resonance
Authors: Blümler Peter , Soltner Helmut 
Published: October 2023

AbstractThis review is a compilation of relevant concepts in designing Halbach multipoles for magnetic resonance applications. The main focus is on providing practical guidelines to plan, design and build such magnets. Therefore, analytical equations are presented for estimating the magnetic field from ideal to realistic systems. Various strategies of homogenizing magnetic fields are discussed together with concepts of opening such magnets without force or combining them for variable fields. Temperature compensation and other practical aspects are also reviewed. For magnetic resonance two polarities (di- and quadrupole) are of main interest, but higher polarities are also included.
Investigation of friction and scuffing during loss of lubrication on a high velocity twin-disc test rig
Authors: Cihak-Bayr Ulrike , Wopelka Thomas , Wintersteiger Christoph 
Published: October 2023

AbstractIncreasing demands on gear components such as high-pressure and high speeds are aggravated by weight saving strategies eliminating an optional secondary lubrication system during negative g operations or windmilling, which result in loss of lubrication conditions (LOL) and scuffing. In order to understand gear design options able to withstand LOL at high velocities, systematic, fundamental studies on model test-rigs, e.g. twin-disc rigs, are required. For this purpose, a twin-disc rig was designed which is able to perform test at high entrainment velocities of up to 80 m/s and high lubricant injection temperatures. Systematic studies have been carried out in continuous lubrication and LOL condition and evaluated in terms of friction and time-of failure (TOF). A mixed EHL model complemented the experimental matrix for wider range of temperatures and additionally compared the influence of the grinding direction on the lubricant gap.Entrainment velocity showed to have the most prominent influence on friction in continuous mode, mostly for the increase from 8 m/s to 23 m/s, followed by minor changes upon further increase to 30 m/s. The influence of injection temperature was mostly prominent at high entrainment velocities. Contact pressure had the strongest influence on TOF. Comparisons with superfinished disc surfaces exhibited a high increase in TOF and significantly less scuffing damage fractures on the runway.
STRONGHOLD first-year results of biomechanically calculated abdominal wall repair: a propensity score matching
Authors: Lesch C. , Nessel R. , Adolf D. , Hukauf M. , Köckerling F. , Kallinowski F. ,   For the STRONGHOLD/Herniamed-Collaborators GROUP, Willms A. , Schwab R. , Zarras K. 
Published: October 2023

Abstract
Purpose
Every year around 70,000 people in Germany suffer from an abdominal incisional hernia that requires surgical treatment. Five years after reconstruction about 25% reoccur. Incisional hernias are usually closed with mesh using various reconstruction techniques, summarized here as standard reconstruction (SR). To improve hernia repair, we established a concept for biomechanically calculated reconstructions (BCR). In the BCR, two formulas enable customized patient care through standardized biomechanical measures. This study aims to compare the clinical outcomes of SR and BCR of incisional hernias after 1 year of follow-up based on the Herniamed registry.

Methods
SR includes open retromuscular mesh augmented incisional hernia repair according to clinical guidelines. BCR determines the required strength (Critical Resistance to Impacts related to Pressure = CRIP) preoperatively depending on the hernia size. It supports the surgeon in reliably determining the Gained Resistance, based on the mesh-defect-area-ratio, further mesh and suture factors, and the tissue stability. To compare SR and BCR repair outcomes in incisional hernias at 1 year, propensity score matching was performed on 15 variables. Included were 301 patients with BCR surgery and 23,220 with standard repair.

Results
BCR surgeries show a significant reduction in recurrences (1.7% vs. 5.2%, p = 0.0041), pain requiring treatment (4.1% vs. 12.0%, p = 0.001), and pain at rest (6.9% vs. 12.7%, p = 0.033) when comparing matched pairs. Complication rates, complication-related reoperations, and stress-related pain showed no systematic difference.

Conclusion
Biomechanically calculated repairs improve patient care. BCR shows a significant reduction in recurrence rates, pain at rest, and pain requiring treatment at 1-year follow-up compared to SR.
A new foundation for the study of bird behaviour: Konrad Lorenz’s ‘Kumpan’ paper of 1935
Authors: Birkhead Tim , Schulze-Hagen Karl 
Published: October 2023

AbstractThe Nobel Prize in Physiology or Medicine was awarded to Konrad Lorenz, Niko Tinbergen and Karl von Frisch in 1973 for their pioneering work during the 1930s and 1940s, in the study of animal behaviour. Lorenz established the foundations of ethology in 1935 in what has become known as his “Kumpan paper”. The paper focussed on the social relationships between conspecifics (i.e. ‘kumpans’, companions) and provided a much-needed conceptual framework for the study of animal behaviour. We describe the origins and immediate reception of Lorenz’s paper using his correspondence with colleagues, mainly Erwin Stresemann who was then the influential editor of Journal für Ornithologie. The Kumpan paper was notable for its extraordinary originality, but also for its length and—in parts—its incomprehensible language. Most of Lorenz’s concepts were rapidly superseded as the field of Ethology/Animal Behaviour developed over the following decades. The paper (translated in full into English only in 1970) is rarely read today, but as we show, many of Lorenz’s observations of birds are both timeless and highly original and have the potential to inspire further research today.
The Strength of Diversity: Macrolithic Artefacts and Productive Forces During the Chalcolithic of Southern Iberia
Authors: Eguíluz Marina , Delgado-Raack Selina , Risch Roberto 
Published: October 2023

AbstractAny approach to the economic organization of a society depends on our knowledge of the productive forces and relations of production involved. In archaeology, this line of research requires an analysis of the technical quality and quantity of the means of production, as well as their spatial distribution and contextualisation. Macrolithic artefacts constituted the means of production in many of the productive processes of past communities, from the Neolithic period to the end of prehistory. This article seeks to utilize macrolithic data to gain a more comprehensive understanding of the economic organisation of the Chalcolithic communities in the southern half of the Iberian Peninsula between c. 3100 and 2200 cal BC. These communities produced one of the most outstanding, but at the same time puzzling archaeological records known in later prehistory. The main aim of this exploratory approach, the first of its kind, is to determine if the different forms of occupation of the Chalcolithic, namely monumental, ditched enclosures, fortified and unfortified hill-top settlements, and simple, open settlements were distinguished by specific modes of production. This issue is crucial to the on-going debate about the meaning and relevance of the notion of social complexity in the context of Chalcolithic societies and their political organisation. Our study describes the productive forces of the Chalcolithic settlements as highly variable, both in the type of productive tasks performed and in their intensity, and such variability is not explained by aspects like geographic location, form of occupation, or monumentality. The observed wealth and productive diversity, without signs of marked social hierarchies, emerge as a characteristic feature of what can be defined as cooperative affluent societies.
Practice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease
Authors: Hung Shao-Min , Adams Sara W. , Molloy Cathleen , Wu Daw-An , Shimojo Shinsuke , Arakaki Xianghong 
Published: October 2023

AbstractEarly screening to determine patient risk of developing Alzheimer’s will allow better interventions and planning but necessitates accessible methods such as behavioral biomarkers. Previously, we showed that cognitively healthy older individuals whose cerebrospinal fluid amyloid/tau ratio indicates high risk of cognitive decline experienced implicit interference during a high-effort task, signaling early changes in attention. To further investigate attention’s effect on implicit interference, we analyzed two experiments completed sequentially by the same high- and low-risk individuals. We hypothesized that if attention modulates interference, practice would affect the influence of implicit distractors. Indeed, while both groups experienced a strong practice effect, the association between practice and interference effects diverged between groups: stronger practice effects correlated with more implicit interference in high-risk participants, but less interference in low-risk individuals. Furthermore, low-risk individuals showed a positive correlation between implicit interference and EEG low-range alpha event-related desynchronization when switching from high- to low-load tasks. This suggests that lower attention on the task was correlated with stronger interference, a typical phenomenon in the younger population. These results demonstrate how attention impacts implicit interference and highlight early differences in perception between high- and low-risk individuals.