bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the efficacy and safety of a proposed biosimilar MSB11456 with tocilizumab reference product in subjects with moderate-to-severe rheumatoid arthritis: results of a randomised double-blind study
Authors: Zubrzycka-Sienkiewicz Anna , Klama Kamilla , Ullmann Martin , Petit-Frere Corinne , Baker Peter , Monnet Joëlle , Illes Andras 
Published: February 2024

ObjectiveTo evaluate the efficacy, immunogenicity and safety of the proposed biosimilar MSB11456 versus European Union (EU)-approved tocilizumab reference product in patients with rheumatoid arthritis (RA) in a multicentre, randomised, double-blind, multinational, parallel-group study (NCT04512001).MethodsAdult patients with moderate-to-severe active RA and inadequate clinical response to ≥1 disease-modifying antirheumatic drug (synthetic or biologic) receiving methotrexate were randomised to receive 24 weekly subcutaneous 162 mg injections of either MSB11456 or EU-approved tocilizumab. Equivalence between treatments was considered if the 95% CI (European Medicines Agency)/90% CI (US Food and Drug Administration) for the difference in mean change from baseline to week 24 in Disease Activity Score-28 Joint Count with erythrocyte sedimentation rate (DAS28-ESR) between treatments was entirely within prespecified equivalence intervals (−0.6 to 0.6 and −0.6 to 0.5, respectively). At week 24, patients were rerandomised to continued treatment or MSB11456. Secondary efficacy endpoints to week 52, and safety and immunogenicity to week 55 were also evaluated.ResultsAt week 24, the least squares mean difference in the change from baseline in DAS28-ESR between treatments was 0.01 (95% CI −0.19 to 0.22) in the 604 randomised patients. Similarity between treatments was shown for all other efficacy, safety and immunogenicity endpoints, including in patients who switched from EU-approved tocilizumab to MSB114466.ConclusionsTherapeutic equivalence was demonstrated for efficacy endpoints, and safety and immunogenicity analyses support the similarity of the two treatments. The results of this study strengthen the evidence that the proposed biosimilar MSB11456 and EU-approved tocilizumab exert similar clinical effects.
Integrated agroforestry system affects the dynamics of inorganic phosphorus fractions in the savanna of Brazilian Northeast
Authors: Silva Alcilane A. , Lacerda Julian J. de J. , de Araújo-Neto Raimundo B. , Sagrilo Edvaldo , Lustosa-Filho José F. , Andrade Hosana A. F. de , de Souza Henrique A. 
Published: February 2024

The savanna (Cerrado) of northeastern Brazil has undergone significant transition in land use to expand agricultural activities. In this region, soils are highly weathered, with phosphorus (P) commonly bound to aluminum (Al) and iron (Fe), creating conditions that demand the supply of P fertilizers to build soil fertility. Conservation systems, such as integrated agroforestry, can increase the inorganic P lability. The aim of this study was to evaluate soil P availability in components of an integrated agroforestry system. Four systems were studied from a 3-year experiment: eucalyptus ( E. urophylla × E. tereticornis) rows (ER), sabiá ( Mimosa caesalpiniifolia) rows (SR), inter-planted maize, and inter-planted soybean in addition to an area of native Cerrado (NC) used as a control. Inter-planted soybean and maize components showed an increase in available P in relation to NC, as a response to a liming-induced increase in soil pH and phosphate fertilization. Eucalyptus and sabiá row components showed an increase in available P in soil because of higher P recycling promoted by forest species and lower P adsorption onto Fe and Al due to the high concentrations of organic matter. Phosphorus forms, following a descending order for all components of the agroforestry system, are P–Al > P–Fe > P–Ca. This information can be used to improve management and soil quality of agricultural production in the Cerrado of the Brazilian northeast region.
Does foreign direct investment cause economic growth in India? An econometric analysis
Authors: Kumar Ranjeet 
Published: February 2024

With the lack of finance, many developing nations are struggling for investment in several areas to generate an opportunity for sustainable livelihood, and Foreign Direct Investment (FDI) emerged as an engine of economic growth, especially in developing nations. It helps to strengthen the economy by mainly promoting capital inflow and technical improvement into the recipient economies. However, some literatures found economic growth, responsible for the inflow of FDI. Therefore, this paper attempts to examine the causal relationship between FDI and Economic Growth in India. By running the Granger causality test in VECM settings, this study found, GDP causes inflow of FDI in India.
Encrypted Video Search with Single/Multiple Writers
Authors: Zheng Yu , Zhang Wenchao , Song Wei , Wang Xiuhua , Fu Chong 
Published: February 2024

Video-based services have become popular. Clients often outsource their videos to the cloud to relieve local maintenance. However, privacy has become a major concern, since many videos contain sensitive information. Although retrieving (unencrypted) videos has been extensively investigated, retrieving encrypted multimedia has received relatively rare attention, at best in a limitation of image-based similarity searches.
We initiate the study of scalable encrypted video search, enabling clients to query videos similar to an image search. Our modular framework leverages intrinsic attributes of videos, such as semantics and visuals, to effectively capture their contents. We propose a two-step approach whereby lightweight searchable encryption techniques are used for pre-screening, followed by an interactive approach for fine-grained search. Furthermore, we present three instantiations, including one centralized-writer instantiation and two distributed-writer instantiations, to effectively cater to varying needs and scenarios: (1) The centralized one employs forward and backward private searchable encryption [CCS 2017] over deep hashing [CVPR 2020]. (2) Motivated by distributed computing, the multi-writer instantiations building atop HSE [Usenix Security 2022] allows searching the relevant videos contributed by multiple intuitions collaboratively. Our experimental results illustrate their practical performance over multiple real-world datasets, whether in a centralized setting or distributed setting.
Natural History of Germline BRCA1 Mutated and BRCA Wild-type Triple-negative Breast Cancer
Authors: Gardi Nilesh , Chaubal Rohan , Parab Pallavi , Pachakar Sunil , Kulkarni Suyash , Shet Tanuja , Joshi Shalaka , Kembhavi Yogesh , Chandrani Pratik , Quist Jelmar , Kowtal Pradnya , Grigoriadis Anita , Sarin Rajiv , Govindarajan Raman , Gupta Sudeep 
Published: February 2024

Abstract

We report a deep next-generation sequencing analysis of 13 sequentially obtained tumor samples, eight sequentially obtained circulating tumor DNA (ctDNA) samples and three germline DNA samples over the life history of 3 patients with triple-negative breast cancer (TNBC), 2 of whom had germline pathogenic BRCA1 mutation, to unravel tumor evolution. Tumor tissue from all timepoints and germline DNA was subjected to whole-exome sequencing (WES), custom amplicon deep sequencing (30,000X) of a WES-derived somatic mutation panel, and SNP arrays for copy-number variation (CNV), while whole transcriptome sequencing (RNA-seq) was performed only on somatic tumor.
There was enrichment of homologous recombination deficiency signature in all tumors and widespread CNV, which remained largely stable over time. Somatic tumor mutation numbers varied between patients and within each patient (range: 70–216, one outlier). There was minimal mutational overlap between patients with TP53 being the sole commonly mutated gene, but there was substantial overlap in sequential samples in each patient. Each patient's tumor contained a founding (“stem”) clone at diagnosis, which persisted over time, from which all other clones (“subclone”) were derived (“branching evolution”), which contained mutations in well-characterized cancer-related genes like PDGFRB, ARID2, TP53 (Patient_02), TP53, BRAF, BRIP1, CSF3R (Patient_04), and TP53, APC, EZH2 (Patient_07). Including stem and subclones, tumors from all patients were polyclonal at diagnosis and during disease progression. ctDNA recapitulated most tissue-derived stem clonal and subclonal mutations while detecting some additional subclonal mutations. RNA-seq revealed a stable basal-like pattern, with most highly expressed variants belonging to stem clone.

Significance:
In germline BRCA1 mutated and BRCA wild-type patients, TNBC shows a branching evolutionary pattern of mutations with a single founding clone, are polyclonal throughout their disease course, and have widespread copy-number aberrations. This evolutionary pattern may be associated with treatment resistance or sensitivity and could be therapeutically exploited.
First records of Microdesmus longipinnis (Weymouth, 1910) (Actinopteri, Gobiiformes, Microdesmidae) for the Brazilian semiarid coast
Authors: Gurgel-Lourenço Ronaldo César , Pinto Leonardo Mesquita , Bezerra Luis Artur Valões , Garcez Danielle Sequeira , Sánchez-Botero Jorge Iván 
Published: February 2024

Microdesmus longipinnis was documented for the first time in the Brazilian semiarid coast. Previous occurrences of this species ranged from the Western Atlantic, North Carolina (USA) to the southeastern coast of Brazil, and there is still a substantial gap between these regions. Specimens were collected in the Curu and Pacoti estuaries, Ceará state, Brazil. These new records of M. longipinnis can help to fill a portion of the geographical distribution gap for species inhabiting estuaries under the semiarid climate of Brazil.
The Hybrid Recharge Delayed Oscillator: A More Realistic El Niño Conceptual Model
Authors: Izumo Takeshi , Colin Maxime , Jin Fei-Fei , Pagli Bastien 
Published: February 2024

Abstract
El Niño–Southern Oscillation (ENSO) is the leading mode of climate interannual variability, with large socioeconomical and environmental impacts, potentially increasing with climate change. Improving its understanding may shed further light on its predictability. Here we revisit the two main conceptual models for explaining ENSO cyclic nature, namely, the recharge oscillator (RO) and the advective–reflective delayed oscillator (DO). Some previous studies have argued that these two models capture similar physical processes. Yet, we show here that they actually capture two distinct roles of ocean wave dynamics in ENSO’s temperature tendency equation, using observations, reanalyses, and Climate Model Intercomparison Project (CMIP) models. The slow recharge/discharge process mostly influences central-eastern Pacific by favoring warmer equatorial undercurrent and equatorial upwelling, while the 6-month delayed advective–reflective feedback process dominates in the western-central Pacific. We thus propose a hybrid recharge delayed oscillator (RDO) that combines these two distinct processes into one conceptual model, more realistic than the RO or DO alone. The RDO eigenvalues (frequency and growth rate) are highly sensitive to the relative strengths of the recharge/discharge and delayed negative feedbacks, which have distinct dependencies to mean state. Combining these two feedbacks explains most of ENSO frequency diversity among models. Thanks to the two different spatial patterns involved, the RDO can even capture ENSO spatiotemporal diversity and complexity. We also develop a fully nonlinear and seasonal RDO, even more robust and realistic, investigating each nonlinear term. The great RDO sensitivity may explain the observed and simulated richness in ENSO’s characteristics and predictability.

Significance Statement
El Niño and La Niña events, and the related Southern Oscillation, cause the largest year-to-year variations of Earth’s climate. Yet the theories behind them are still debated, with two main conceptual models being the recharge oscillator and the delayed oscillator. Our purpose here is to address this debate by developing a more realistic theory, a hybrid recharge delayed oscillator. We show how simple yet realistic it is, with equivalent contributions from the slow recharge process and from the faster delayed feedback. It even captures the observed El Niño and La Niña diversity in space and in frequency. Future studies could use the simple theoretical framework provided here to investigate El Niño–Southern Oscillation (ENSO) in observations, theories, climate models diagnostics and forecasts, and global warming projections.
Diverse Characteristics of Extreme Orographic Snowfall Events in Little Cottonwood Canyon, Utah
Authors: Wasserstein Michael L. , Steenburgh W. James 
Published: February 2024

Abstract
Heavy orographic snowfall can disrupt transportation and threaten lives and property in mountainous regions but benefits water resources, winter sports, and tourism. Little Cottonwood Canyon (LCC) in northern Utah’s Wasatch Range is one of the snowiest locations in the interior western United States and frequently observes orographic snowfall extremes with threats to transportation, structures, and public safety due to storm-related avalanche hazards. Using manual new-snow and liquid precipitation equivalent (LPE) observations, ERA5 reanalyses, and operational radar data, this paper examines the characteristics of cool-season (October–April) 12-h snowfall extremes in upper LCC. The 12-h extremes, defined based on either 95th percentile new snow or LPE, occur for a wide range of crest-level flow directions. The distribution of LPE extremes is bimodal with maxima for south-southwest or north-northwest flow, whereas new-snow extremes occur most frequently during west-northwest flow, which features colder storms with higher snow-to-liquid ratios. Both snowfall and LPE extremes are produced by diverse synoptic patterns, including inland-penetrating or decaying atmospheric rivers from the south through northwest that avoid the southern high Sierra Nevada, frontal systems, post-cold-frontal northwesterly flow, south-southwesterly cold-core flow, and closed low pressure systems. Although often associated with heavy precipitation in other mountainous regions, the linkages between local integrated water vapor transport (IVT) and orographic precipitation extremes in LCC are relatively weak, and during post-cold-frontal northwesterly flow, highly localized and intense snowfall can occur despite low IVT. These results illustrate the remarkable diversity of storm characteristics producing orographic snowfall extremes at this interior continental mountain location.

Significance Statement
Little Cottonwood Canyon in northern Utah’s central Wasatch Range frequently experiences extreme snowfall events that pose threats to lives and property. In this study, we illustrate the large diversity of storm characteristics that produce this extreme snowfall. Meteorologists commonly use the amount of water vapor transport in the atmosphere to predict heavy mountain precipitation, but that metric has limited utility in Little Cottonwood Canyon where heavy snowfall can occur with lower values of such transport. Our results can aid weather forecasting in the central Wasatch Range and have implications for understanding precipitation processes in mountain ranges throughout the world.
Serum Trefoil Factor-3 Predicts Survival in Peripheral Artery Disease
Authors: Pesau Gerfried , Zierfuss Bernhard , Hoebaus Clemens , Koppensteiner Renate , Schernthaner Gerit-Holger 
Published: February 2024

Trefoil factor 3 (TFF3) has been studied in processes leading to atherosclerosis. Data are scarce in manifest disease and missing in peripheral artery disease (PAD). This study aims to elucidate TFF3 with disease stages, degrees of atherosclerosis, and outcomes. TFF3 was measured in serum in 364 PAD patients without critical limb ischemia and mild to moderate chronic kidney disease (CKD). Mortality data were retrieved from the Austrian central death registry (median observation 9.6 years). Survival analyses were performed using Cox regression and the Kaplan–Meier method. A negative association between ankle-brachial index and TFF3 ( P < .001) was observed, while levels were similar in asymptomatic and symptomatic PAD. TFF3 increased with history of cardiovascular and cerebrovascular disease ( P < .001). TTF3 was associated with the estimated glomerular filtration rate (R = −0.617, P < .001) and urinary albumin-creatinine ratio (R = 0.229, P < .001). One SD increase in TFF3 showed a worsening in all-cause mortality (hazard ratio 1.68, CI 1.37–2.05) which persisted after multiple adjustment for cardiovascular risk, inflammatory, and angiogenetic markers (hazard ratio 1.35, CI 1.01–1.81). This study is the first to link TFF3 with both disease markers and outcomes in PAD. TFF3 demonstrated associations with renal function, PAD severity measured by ankle-brachial index, and additional atherosclerotic burden in PAD.
Longitudinal outcomes of a work inclusion program in mental health departments in the city of Milan
Authors: Vanzetto Simone , Quarenghi Andrea , Varinelli Alberto , Dragoni Chiara , Conti Dario , Boscacci Maria , Carrà Giuseppe , Percudani Mauro , Morganti Carla , Gambini Orsola , Barbieri Valentina , Brambilla Paolo , Lazzaretti Matteo , Rubelli Paola , Mencacci Claudio , Fusi Antonio , Viganò Caterina , Dell’Osso Bernardo 
Published: February 2024

Background: Work functioning impairment is a key diagnostic and prognostic criterion in patients with psychiatric disorders and work inclusion is a major goal of their therapeutic pathway. Since 2009, the Regional Innovative Program (PIR) TR106, promoted by ASST Fatebenefratelli-Sacco of Milan in collaboration with other Departments of Mental Health and Addictions (DSMDs) in the town of Milan (Italy), has been developing the employment inclusion of psychiatric patients. Aims: The objective of this study is to evaluate its outcomes over 8 years of observation. Method: We reported the results of a retrospective epidemiologic analysis on 2,142 interventions on 1,066 patients recruited, investigating PIR TR106 outcomes per year focusing on different subgroups. We focused on ‘positive’, ‘negative’, and ‘other’ outcomes. Results: We preliminary calculated job maintenance interventions (5%, 107) and excluded these interventions from the overall. We observed 29 job firing (1.4%) and 15 job resignations (0.7%) as negative results (equal to 2.2% of the total) and 388 job hiring (16.6%), 647 traineeships (31.8%), and 413 work formation (20.3%) as positive outcomes (equal to 68.75%). In other outcomes (29.1%) we found 305 dismissals from PIR TR 106 (15%) and transitory outcomes (14.1%). Job hiring increased from 8.9% in 2012 to 23.8 % in 2019 ( p < .001), while the dismissals diminished from 26.7% to 13.3% ( p < .001). The effectiveness of traineeships in terms of job hiring increased in the ratio of annual job hiring versus job traineeship (+48.8%). The majority of hired patients (15.1%) were affected by a psychotic disorder. A significant hiring increase was observed in patients with psychotic disorders and personality disorders ( p < .005). Conclusions: PIR-TR106 represents a territorial employment inclusion program with progressively increasing effectiveness and specificity, as suggested by changes in outcomes during the 8-year observation. The adaptive capacity and sustainability of the intervention are worth further investigation.
Producing domestic energy benchmarks using a large disaggregate stock model
Authors: Godoy-Shimizu Daniel , Liddiard Rob , Evans Stephen , Hong Sung Min , Humphrey Dominic , Ruyssevelt Paul , Mumovic Dejan , Steadman Philip 
Published: February 2024

Within the UK, domestic buildings account for 16% of total national emissions. Considerable improvements to the performance of the existing building stock will be necessary in the context of the UK’s commitment to emissions reductions, and for this to be achieved successfully and efficiently will require an improved understanding of the current performance of the stock. This paper presents an analysis of metered gas and electricity use from 808,559 dwellings with detailed building characteristic data in London, showing how energy use can be examined using a highly detailed, fully disaggregate building stock model. New gas and electricity benchmarks have been produced for houses (split by the level of attachment) and flats, for both gas- and electrically-heated properties. The paper shows how energy use varies with form, and how the choice of units influences the relative performance of different types. Comparing gas use across the types, for example, when calculated as kWh/m2, consumption follows building compactness, but when calculated as kWh/household, the trends follow building size. Finally, the paper examines how energy use varies with building thermal performance, using the Heat Loss Parameter (HLP), a standardised measure which accounts for thermal transfer through building envelopes as well as via air flow. Practical Application: This paper presents domestic energy consumption benchmarks based on measured not modelled data, produced from a large sample of London houses and flats. Results are shown for different dwelling types and heating fuels. Additionally, the relationship between gas use and envelope thermal performance is explored. The results will hopefully be beneficial for researchers, policy-makers and designers interested in better understanding current domestic energy use, and informing decisions about future improvements to energy efficiency within the stock. This paper also provides details for anyone interested in the production of the domestic benchmarks for the CIBSE benchmarking tool.
UTIL: An ultra-wideband time-difference-of-arrival indoor localization dataset
Authors: Zhao Wenda , Goudar Abhishek , Qiao Xinyuan , Schoellig Angela P. 
Published: February 2024

Ultra-wideband (UWB) time-difference-of-arrival (TDOA)-based localization has emerged as a promising, low-cost, and scalable indoor localization solution, which is especially suited for multi-robot applications. However, there is a lack of public datasets to study and benchmark UWB TDOA positioning technology in cluttered indoor environments. We fill in this gap by presenting a comprehensive dataset using Decawave’s DWM1000 UWB modules. To characterize the UWB TDOA measurement performance under various line-of-sight (LOS) and non-line-of-sight (NLOS) conditions, we collected signal-to-noise ratio (SNR), power difference values, and raw UWB TDOA measurements during the identification experiments. We also conducted a cumulative total of around 150 min of real-world flight experiments on a customized quadrotor platform to benchmark the UWB TDOA localization performance for mobile robots. The quadrotor was commanded to fly with an average speed of 0.45 m/s in both obstacle-free and cluttered environments using four different UWB anchor constellations. Raw sensor data including UWB TDOA, inertial measurement unit (IMU), optical flow, time-of-flight (ToF) laser altitude, and millimeter-accurate ground truth robot poses were collected during the flights. The dataset and development kit are available at https://utiasdsl.github.io/util-uwb-dataset/ .