bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specialized pediatric palliative care in Italy: where are we going? The Palliped 2022–2023 study
Authors: Benini Franca , Mercante Anna , Di Nunzio Sara , Papa Simonetta ,   the PalliPed 2022-2023 Working Group, Amarri Sergio , Barrocu Laura , Bolognani Marco , Calì Monica , Catalano Gaetano , Celentano Loredana , De Zen Lucia , Lazzarin Pierina , Lijoi Stefano , Manfredini Luca , Molinaro Grazia , Moliterni Paola , Orofino Rocco , Pellegatta Federico , Pizzi Simone , Raspi Marina , Salata Michele , Tornesello Assunta , Vezzoli Cesare 
Published: January 2025

Abstract

Background
The PalliPed project is a nationwide, observational, cross-sectional study designed with the aim of providing a constantly updated national database for the census and monitoring of specialized pediatric palliative care (PPC) activities in Italy. This paper presents the results of the first monitoring phase of the PalliPed project, which was developed through the PalliPed 2022–2023 study, to update current knowledge on the provision of specialized PPC services in Italy.

Methods
Italian specialized PPC centers/facilities were invited to participate and asked to complete a self-reporting, ad-hoc, online survey regarding their clinical activity in 2022–2023, in the revision of the data initially collected in the first PalliPed study of 2021.

Results
18 specialized PPC centers/facilities from 14 Italian regions and two autonomous provinces participated; 13 were identified as regional referral centers (72.2%), with the acquisition of three new centers in comparison to 2021. Full coverage of the regional territory was reported by 54% of them, compared with 45% in 2021, while a 24/7 service was offered by 23%, compared with 27% in 2021. Eight of 13 referral centers (61%) had a dedicated team, compared with 91% in 2021. Also, an overall increase in the number of followed patients was observed, rising from 1,209 (2019) to 2,734 (2023). In line with previous data, most PPC healthcare providers were nurses (n = 181) and physicians (n = 89), with an overall increased number of PPC providers from 2021.

Conclusions
The nationwide PalliPed project established the first comprehensive overview and monitoring of the state of specialized PPC in Italy. Data reported within the PalliPed 2022–2023 monitoring study suggest a general improving trend in the availability of the specialized PPC service in Italy, compared with data collected in 2021. At the same time, the need for a greater effort to provide better care models and resources for specialized PPC remains, especially considering that the number of children needing PPC is constantly increasing.
A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model
Authors: Randell Alison M. , Salia Stephanie , Fowler Lucas F. , Aung Toe , Puts David A. , Swift-Gallant Ashlyn 
Published: January 2025

Abstract
As the earliest measure of social communication in rodents, ultrasonic vocalizations (USVs) in response to maternal separation are critical in preclinical research on neurodevelopmental disorders (NDDs). While sex differences in both USV production and behavioral outcomes are reported, many studies overlook sex as a biological variable in preclinical NDD models. We aimed to evaluate sex differences in USV call parameters and determine if USVs are differently impacted based on sex in the preclinical maternal immune activation (MIA) model. Results indicate that sex differences in USVs vary with developmental stage and are more pronounced in MIA offspring. Specifically, developmental stage is a moderator of sex differences in USV call duration, with control females emitting longer calls than males in early development (up to postnatal day [PND] 8), but this pattern reverses after PND8. MIA leads to a reduction in call numbers for females compared to same-sex controls in early development, with a reversal post-PND8. MIA decreased call duration and increased total call duration in males, but unlike females, developmental stage did not influence these differences. In males, MIA effects varied by species, with decreased call numbers in rats but increased call numbers in mice. MIA timing (gestational day ≤ 12.5 vs. > 12.5) did not significantly affect results. Our findings highlight the importance of considering sex, developmental timing, and species in USVs research. We discuss how analyzing USV call types and incorporating sex as a biological variable can enhance our understanding of neonatal ultrasonic communication and its translational value in NDD research.
Extremely early initiation of vasopressors might not decrease short-term mortality for adults with septic shock: a systematic review and meta-analysis
Authors: Ma Cheng-Hsin , Healy Jack , Kinteh Ebrima , Ma Cheng-Chin , Tzeng Ching-Fang Tiffany , Chou Eric H. , Wu Chin-Chieh , Shao Shih-Chieh , Chen Kuan-Fu 
Published: January 2025

Abstract

Background
The optimal timing for initiating vasopressor therapy in patients with septic shock remains unclear. This study aimed to assess the impact of early versus late vasopressor initiation on clinical outcomes.

Methods
A systematic review and meta-analysis were conducted by searching PubMed, Embase, and Cochrane databases. Studies comparing early and late vasopressor administration in septic shock patients were included. The primary outcome was short-term mortality, and subgroup analyses were performed based on different initiation timings.

Results
Eleven studies with 6,661 patients were included. Different studies define the ‘early administration’ timeframe variously, ranging from one to seven hours. No significant difference in short-term mortality was observed between early and late administration in the combined analysis of 3,757 patients from two RCTs and three quasi-experimental studies (OR: 0.66, 95% CI: [0.36, 1.19], I²: 82%). However, lower mortality was found in subgroups with early but not extremely early initiation (one to three hours, OR: 0.70, 95% CI: [0.60, 0.82], I²: 0%), and those using septic shock diagnosis as time zero (OR: 0.64, 95% CI: [0.48, 0.85], I²: 39%).

Conclusion
Our findings found that earlier initiation of vasopressor therapy, particularly within one to three hours after the diagnosis of septic shock, may be associated with reduced short-term mortality in certain subgroups. However, due to the heterogeneity in study definitions and potential confounding factors, these results should be interpreted cautiously. Further standardized investigations are warranted to precisely determine the optimal timing for vasopressor initiation to maximize survival outcomes in patients with septic shock.
Financial inclusion and fintech: a state-of-the-art systematic literature review
Authors: Ha Dao , Le Phuong , Nguyen Duc Khuong 
Published: January 2025

Abstract
This study presents an all-inclusive analysis of the literature on the augmentation of financial inclusion through fintech. Ninety-six papers were selected from the 2951 articles in the Web of Science, Scopus, and EBSCO databases. This study uses bibliometric and content analysis techniques to illuminate the underexplored aspects of fintech’s impact on financial inclusion. Unlike previous studies, this study consolidates a significant amount of the literature on financial inclusion by systematically contextualizing theories and viewpoints from the fintech sector. The key findings include the identification of three main research clusters: (1) the advent of novel services, (2) the transformation of the market landscape, and (3) the roles of stakeholders in the fintech ecosystem. The analysis reveals gaps in the existing research, such as the need for more studies on the tangible impact of fintech on financial inclusion and regulation. This study concludes by highlighting potential directions for future research and emphasizing the importance of policymakers paying greater attention to fintech’s implications for financial inclusion.
Perceptions of social interactions and second language willingness to communicate in different activities
Authors: Han He , Li Bing 
Published: January 2025

Abstract
This study examined whether students’ perceived social interactions within different learning activities predicted their willingness to communicate (WTC) in second language (L2) classrooms. The sample was 932 undergraduate students from 8 universities learning English as a foreign language. Data of student-perceived social interactions in classrooms including teacher-student relationships, peer relationships, cooperation and equity, and data of WTC including overall WTC, WTC in meaning-focused activities, and WTC in form-focused activities were collected through online questionnaires. Data analysis using Structural Equation Modelling showed that (1) teacher-student relationships, peer relationships and cooperation positively predicted overall WTC; (2) teacher-student relationships, peer relationships, cooperation and equity positively predicted WTC in meaning-focused activities; (3) cooperation positively but equity negatively predicted WTC in form-focused activities. The results suggested that students’ perceived social interactions had predictive effects on L2 WTC but such effects differed in line with learning activity types. Implications for enhancing WTC in L2 instruction were also discussed.
Commonly prescribed medications and risk of pneumonia and all-cause mortality in people with idiopathic pulmonary fibrosis: a UK population-based cohort study
Authors: Morgan Ann D. , Massen Georgie M. , Whittaker Hannah R. , Stewart Iain , Jenkins Gisli , George Peter M. , Quint Jennifer K. 
Published: January 2025

Abstract

Background
A growing body of evidence suggests that prolonged use of inhaled corticosteroids (ICS) and proton pump inhibitors (PPIs) is associated with increased risks of pneumonia. A substantial proportion of people with idiopathic pulmonary fibrosis (IPF) are prescribed PPIs or ICS to treat common comorbidities, giving rise to concerns that use of these medications may be associated with potential harms in this patient population.

Methods
We used UK Clinical Practice Research Datalink (CPRD) Aurum primary care data linked to national mortality and hospital admissions data to create a cohort of people diagnosed with IPF on or after 1 January 2010. Patients were assigned to one of three exposure categories according to their prescribing history in the 12 months prior to IPF diagnosis as follows: “regular” users (≥ 4 prescriptions), “irregular” users (1–3 prescriptions) and “non-users” (no prescriptions). We explored the association between PPI/ICS prescription and pneumonia hospitalisation and all-cause mortality using multinomial Cox regression models.

Results
A total of 17,105 people met our study inclusion criteria; 62.6% were male and 15.9% were current smokers. Median age at IPF diagnosis was 76.7 years (IQR: 69.6–82.7). 19.9% were regularly prescribed PPIs, and 16.0% ICS, prior to IPF diagnosis. Regular prescribing of PPIs and ICS was positively associated with hospitalisation for pneumonia; the adjusted HR for pneumonia hospitalisation comparing regular PPI users with non-users was 1.14 (95%CI: 1.04–1.24); for regular ICS users the corresponding HR was 1.40 (95%CI: 1.25–1.55). We also observed a small increased risk for all-cause mortality in the “regular ICS user” group compared with the “non-user” control group (HRadj = 1.19, 1.06–1.33). We found no evidence of an association between PPI prescribing and all-cause mortality.

Conclusion
Prolonged prescription of medications used to treat common comorbidities in IPF may be associated with increased risks for severe respiratory infections. These findings point to a need to adopt an adequate risk–benefit balance approach to the prescribing of ICS-containing inhalers and PPIs in people with IPF without evidence of comorbidities, especially older patients and/or those with more advanced disease in whom respiratory infections are more likely to result in poorer outcomes.
Angus: efficient active learning strategies for provenance based intrusion detection
Authors: Wu Lin , Xie Yulai , Li Jin , Feng Dan , Liang Jinyuan , Wu Yafeng 
Published: January 2025

Abstract
As modern attack methods become more concealed and complex, obtaining many labeled samples in big data streams is difficult. Active learning has long been used to achieve better intrusion detection performance by using only a small number of training samples. Intrusion behaviors can be described by provenance graphs that record the dependency relationships between intrusion processes and the infected files. It is a challenge to develop active learning strategies that consider defining and selecting the most valuable provenance and ensure that the strategy for querying provenance is efficient. We present Angus, an active learning framework for provenance-based intrusion detection. We propose two novel active learning strategies: the most similar graph query strategy and the maximum difference query strategy. They either select samples to update the training set according to similarities of provenance graphs or preferentially select samples with low redundancy and large differences from the current training set. Besides, we also improve the above query strategies by using the parallel query to reduce detection time overheads. The experiments on various real-world applications demonstrate their performance and efficiency.
Pyrogallol acts as a novel anticancer factor to enhance the sensitivity to cisplatin in ovarian cancer cells through inducing miR-15a upregulation
Authors: Shirani Azin , Mirabbasi Razieh , Shabani Leila , Reiisi Somayeh 
Published: January 2025

Abstract

Introduction
Pyrogallol is a catechin compound, as an active ingredient extracted from Emblica officinalis, has antiproliferative and antiapoptotic effects on some of the human cancer cells. Cisplatin is known as an effective chemotherapeutic agent against cancer by inducing DNA damage and apoptosis. However, the effect of pyrogallol alone and in combination with cisplatin on proliferation and apoptosis of ovarian cancer has not yet been reported.

Methods
In the present study, ovarian carcinoma cell line A2780 was cultivated, and the anticancer properties of pyrogallol and cisplatin determined by cell treatment of the two drugs separately and combination. Cell viability and apoptosis rate was investigated by MTT assay and flow cytometry. The effects of the compounds in inhibiting colony formation and migration were measured by colony formation and scratch methods.

Results
The results of the present study revealed that pyrogallol significantly inhibited the proliferation of A2780 cells in a dose-dependent manner. The combination treatment of pyrogallol and cisplatin exhibited a prominent inhibitory effect on the growth, colony formation and migration, and increased the induction of apoptosis up to 2.5 times compared to single treatments. Also, the qPCR results showed a significant increase in the expression of miR-15a and a decrease in the expression of miRNA target genes under treatment with the drugs both separately and in their combination.

Conclusion
This study suggests that the combination treatment of pyrogallol and cisplatin significantly increases the death of ovarian cancer cells by inducing apoptosis. Therefore, it can boost the efficacy of chemotherapy and reduce its side effects. It is hoped that the findings of the present study can provide a new perspective for pyrogallol as a therapeutic agent in the treatment of ovarian cancer.
Sustainable digital leap: a bibliometric study on its impact on human learning and organizational development in the MENA region
Authors: Singh Ajay 
Published: January 2025

Abstract
The study aims to explore how sustainable digital transformation affects human learning and organizational development in MENA region using bibliometric analysis. The researchers used Scopus and WOS databases for data extraction. The researcher analyzed the cumulative data using performance analysis, and scientific mapping with VOS Viewer software. The findings indicated that Blau, I from Israel is the leading author, King Faisal University from Saudi Arabia is the most productive institution, “International Journal of Emerging Technologies in Learning” is the most productive journal, and “Investigating users’ perspectives on e-learning: An integration of TAM and IS success” is the highly cited article in target domain. Furthermore, the scientific mapping indicated that Saudi Arabia has highest co-author country collaboration. Finally, E-learning is the high co-occurred keyword because of collaborative research from MENA region for the subject. The study provides most productive author, institutions, journal, articles, country, and keyword in order to understand the literature for the impact of sustainable digital transformation on human learning and organizational development from MENA region.
How to improve psychiatric nosography in the XXI century: a phenomenologist”s viewpoint
Authors: Stanghellini Giovanni 
Published: January 2025

Abstract
Classifications of mental disorders reflect much more the minds of psychiatrists than the patients’ minds since these classifications are more focused on the interests of stakeholders (including governmental agencies, advocacy groups, medical insurance, and pharmaceutical companies) than on the experiences of patients. We live in times of rapid socio-cultural changes, and respective changes in the forms of mental suffering are increasingly characterized by fragmentariness and episodicity. These new forms of suffering may escape nosographic framing based on the identification of symptoms and syndromes. A paradigm shift in the psychiatric nosography is necessary. The way forward could be to enhance the ability of clinicians to grasp the “fragments” provided by patients rather than aggregations of symptoms. “Existential knots” can manifest themselves in these fragments to be used as “floating buoys” for clinical navigation, in the absence of exhaustive and detailed “maps” of the symptoms and syndromes that afflict patients. A tentative collection of these existential knots is provided, building on and extending the legacy of existential philosophy and phenomenological psychopathology.
Correlates of Cetuximab Efficacy in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma Previously Treated With Immunotherapy
Authors: Park Jong Chul , Ahn Jong Seok , Merkin Ross , Patel Manisha , Wirth Lori , Roberts Thomas J. 
Published: January 2025

PURPOSE
Immune checkpoint inhibitors (ICIs) are now first-line therapy for most patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), and cetuximab is most often used as subsequent therapy. However, data describing cetuximab efficacy in the post-ICI setting are limited.

METHODS
We performed a single-institution retrospective analysis of patients with R/M HNSCC treated with cetuximab, either as monotherapy or in combination with chemotherapy, after receiving an ICI. We extracted objective response rate (ORR), duration of treatment (DOT), and overall survival (OS) and compared them on the basis of patient characteristics. Multivariable models assessed associations between patient and tumor characteristics and outcomes.

RESULTS

We identified 70 patients treated with cetuximab after an ICI. The mean age was 67.6 years, with 60% having virus-associated HNSCC. Overall, the ORR was 21.4%, the median DOT was 1.9 months, and the median OS was 6.3 months. Patients receiving cetuximab with chemotherapy had a higher ORR (27.7%
v
8.7%) and longer median DOT but similar OS compared with monotherapy. Virus-independent HNSCC had higher ORR (28.6%
v
10.7%), longer DOT (3.3
v
1.2 months; hazard ratio [HR], 0.47 [95% CI, 0.25 to 0.90]), and longer OS (8.1
v
4.6 months; HR, 0.40 [95% CI, 0.19 to 0.83]). In multivariable models, virus-independent disease and negative smoking history were associated with improved OS. Concurrent chemotherapy, age, and sex were not associated with differences in OS. When assessing genomic data,
TP53
mutations were associated with improved DOT (HR, 0.33 [95% CI, 0.15 to 0.70]) and OS (HR, 0.38 [95% CI, 0.17 to 0.86]).

CONCLUSION
Cetuximab-based therapy shows limited efficacy in R/M HNSCC post-ICI, although outcomes were better in virus-independent HNSCC and nonsmokers. The findings may improve prognostication and patient selection for cetuximab after ICI in R/M HNSCC.
Impact of Weak Vibration Generated by a Refrigerator on Protein Aggregation
Authors: Kizuki Shinji , Wang Zekun , Yamauchi Satoru , Torisu Tetsuo , Uchiyama Susumu 
Published: January 2025

Abstract
Protein aggregates and particles in biopharmaceuticals can induce adverse immune responses in patients. Thus, suppression of the formation of protein aggregates and particles is important for the successful development of therapeutic proteins. Mechanical stresses, including agitation, are widely recognized as stress factors that generate protein aggregates and particles. However, although refrigerators and storage chambers generate weak vibration, there have been no studies of the impact of such weak vibration on aggregate and particle formation during storage. In this study, monomer loss and aggregate formation of a CTLA4-Ig were evaluated during storage in a refrigerator (having a vibration acceleration less than 0.006 G) with or without three vibration isolators. The vibration isolators reduced the vibration acceleration, thereby decreasing the rate of monomer loss and nanometer-sized aggregate formation. The increase in the aggregation rate due to the weak vibration was not mitigated by adding poloxamer 188 or eliminating the air–liquid interface, which are processes known to be effective in preventing protein aggregation due to mechanical stresses. Thus, reducing vibration should be an effective way to mitigate the risk of aggregate formation.

Graphical Abstract
Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver
Authors: Dye Janice A , Stewart Erica J , Schladweiler Mette C , Nguyen Helen H , Grindstaff Rachel D , Padgett William T , Fisher Anna A , Miller Colette N 
Published: January 2025

Abstract
Maternal exposure to ozone during implantation results in reduced fetal weight gain in rats. Offspring from ozone-exposed dams demonstrate sexually dimorphic risks to high-fat diet feeding in adolescence. To better understand the adolescent hepatic metabolic landscape following fetal growth restriction, RNA sequencing was performed to characterize the effects of ozone-induced fetal growth restriction on male and female offspring. Pregnant Long–Evans rats were exposed to filtered air or 0.8 ppm ozone for 4 hours on both gestation days 5 and 6 (n = 6/group). At approximately postnatal day 48, liver tissue was obtained for RNA sequencing from offspring. Peri-implantation exposure to ozone in the dam had greater effects on hepatic gene expression in male offspring than in the females. Interestingly, heatmaps of these differentially expressed genes suggested that male offspring from ozone-exposed dams had a transcriptomic pattern like that of female offspring. Using a filtered set of highly female-predominant genes (n = 390), 57% were upregulated in the male offspring from ozone-exposed dams. Upregulated canonical pathways included sirtuin and orexin signaling, estrogen receptor signaling, and integration of energy metabolism. Relatively few genes altered in the male offspring from ozone-exposed dams were associated with endpoints of sexual maturity, signifying the likely source of the observed feminization was not attributed to sex hormones. This study provides initial evidence that growth restriction in utero may increase the risk of hepatic feminization in male offspring. Additional work is needed to further understand the relationship between developmental undernutrition and feminization in the male liver.