bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coral reef state influences resilience to acute climate‐mediated disturbances
Authors: Cresswell Anna K. , Renton Michael , Langlois Tim J. , Thomson Damian P. , Lynn Jasmine , Claudet Joachim 
Published: October 2023

AbstractAimThe aim of this study was to understand the interplay between resistance and recovery on coral reefs, and to investigate dependence on pre‐ and post‐disturbance states, to inform generalizable reef resilience theory across large spatial and temporal scales.LocationTropical coral reefs globally.Time Period1966–2017.Major Taxa StudiedScleractinian hard corals.MethodsWe conducted a literature search to compile a global data set of total coral cover before and after acute storms, temperature stress and coastal run‐off from flooding events. We used meta‐regression to identify variables that explained significant variation in disturbance impact, including disturbance type, year, depth and pre‐disturbance coral cover. We further investigated the influence of these same variables, as well as post‐disturbance coral cover and disturbance impact, on recovery rate. We examined the shape of recovery, assigning qualitatively distinct, ecologically relevant, population growth trajectories: linear, logistic, logarithmic (decelerating) and a second‐order quadratic (accelerating).ResultsWe analysed 427 disturbance impacts and 117 recovery trajectories. Accelerating and logistic were the most common recovery shapes, underscoring non‐linearities and recovery lags. A complex but meaningful relationship between disturbance impact, the state of a reef pre‐ and post‐disturbance, and recovery rate was identified. Fastest recovery rates were predicted for intermediate to large disturbance impacts, but a decline in this rate was predicted when more than ~75% of pre‐disturbance cover was lost. We identified a shifting baseline, with declines in both pre‐ and post‐disturbance coral cover over the 50‐year study period.Main ConclusionsWe break down the complexities of coral resilience, showing interplay between resistance and recovery, as well as dependence on both pre‐ and post‐disturbance states, alongside documenting a chronic decline in these states. This has implications for predicting coral reef futures and implementing actions to enhance resilience.
Wilhelm Speyer's best‐selling novels of 1927 and male responses to female emancipation
Authors: Heady Katy 
Published: October 2023

AbstractThe Weimar Republic witnessed significant advances in the professional, political, and social opportunities available to German women, as well as a substantial increase in the visibility of women within the German public sphere. Existing research into the reactions of German men to female emancipation during this period has tended to focus on the fear and hostility that were most noticeable during the early years of the Republic. In contrast, this article discusses two more supportive responses to female liberation: Wilhelm Speyer's best‐selling novels Charlott etwas verrückt (1927) and Der Kampf der Tertia (1927). These novels depict their unconventional and powerful women protagonists in a sympathetic light, but their emancipatory potential is limited by the use of traditional motifs and perspectives within their descriptions of female characters.
Efficacy, safety and cost of emicizumab prophylaxis in haemophilia A patients with inhibitors: A nationwide observational study in Taiwan
Authors: Shen Ming‐Ching , Chou Sheng‐Chieh , Chiou Shyh‐Shin , Lin Pei‐Chin , Chen Yeu‐Chin , Lin Hsuan‐Yu , Lee Yang‐Cheng , Huang Cih‐En , Weng Te‐Fu , Huang Ting‐Huan , Chung Chih‐Yuan , Chen Jiann‐Shiuh , Chen Shu‐Huey , Cheng Shin‐Nan , Hsiao Chih‐Cheng , Huang Yen‐Min , Chen Shih‐Hsiang , Yu Yuan‐Bin , Lin Shih‐Chiang , Lin Ching‐Yeh , Peng Ching‐Tien , Wang Jiaan‐Der ,   Taiwan Society of Thrombosis and Hemostasis study group
Published: October 2023

AbstractIntroductionEmicizumab mimicking the cofactor function of activated factor VIII (FVIII) restores haemostasis.MethodsThis nationwide observational study aimed to retrospectively investigate efficacy, safety, and cost in 1 year before and up to 3 years after emicizumab prophylaxis for haemophilia A (HA) patients with FVIII inhibitors.Results and discussionA total of 39 severe HA patients with a median age of 23.0 years were enrolled. The median historical peak FVIII inhibitor titre was 174.2 BU/mL with an interquartile range of 56.5–578.8 BU/mL. The median annualized bleeding rate reduced from 24 to 0 events in the first year after emicizumab prophylaxis (p < .01) and sustained in the second and third years. The median annualized joint bleeding rate reduced to 0 and maintained up to 3 years (p < .01). Twenty‐seven patients (69.2%) had target joints before emicizumab prophylaxis and only seven patients (17.9%) of them had target joints after prophylaxis. Medical costs, including cost of haemostatic therapy, frequency of outpatient department visits, emergency room visits and hospital admission, were significantly reduced after emicizumab prophylaxis (p < .01). FVIII inhibitor titre decreased after emicizumab prophylaxis. Overall, three (7.7%) patients experienced 202 grade 1 drug‐related adverse events after emicizumab prophylaxis. No serious adverse events were reported during emicizumab prophylaxis period. The adherence to emicizumab prophylaxis was 100% up to 3 years.ConclusionsHA patients with FVIII inhibitors treated with emicizumab prophylaxis resulted in a significant reduction in treated bleeds and associated costs. No new safety events were observed.
Two‐center validation of assays for the detection of binding and neutralizing anti‐factor VIII antibodies
Authors: Müller Jens , Neimanis Sonja , Kahle Jörg , Albert Thilo , Schultze Strasser Stephan , Rup Bonita , Pötzsch Bernd , Königs Christoph , Oldenburg Johannes ,   the ABIRISK Consortium
Published: October 2023

AbstractIntroductionPatients with hemophilia A treated with coagulation Factor VIII (FVIII) products are at risk for developing anti‐FVIII antibodies. The ABIRISK Consortium aimed to provide knowledge on the formation and detection of anti‐drug antibodies against biopharmaceutical products, including FVIII. Accordingly, standardized and validated assays for the detection of binding (total) and neutralizing antibodies are needed.AimTwo‐center validation of an ELISA for the detection of total FVIII‐binding IgG‐antibodies and Nijmegen‐Bethesda assays for the quantification of FVIII‐neutralizing antibodies according to consensus validation guidelines.MethodsValidation of assays at both sites was done according to published recommendations and included preanalytics, the determination of key assay parameters, including cut‐points, assay sensitivity, precision, and FVIII interference.ResultsThe validated assays reproducibly detected FVIII‐binding and ‐neutralizing antibodies with comparable performance in both laboratories. Floating screening cut‐points were established for both assays. Determined mass‐based sensitivity of both assays (all values ≤66 ng/mL) complied with the minimum sensitivity for the detection of anti‐drug antibodies as recommended by the FDA (<100 ng/mL). Intra‐ and inter‐assay coefficients of variation did not exceed 25%. Assay validation further revealed that pre‐analytical heat treatment led to potentially false‐positive ELISA results, while up to 0.15 IU/mL, residual FVIII showed no significant impact. Overall, good agreement of results was found for patient samples analyzed at both study sites.ConclusionComprehensive validation of different anti‐FVIII‐antibody assays in two laboratories gave novel insights into the impact of pre‐analytical sample treatment as well as the comparability of test results generated by the use of methodically different assays.
Long‐term quantitative hepatitis B surface antigen (HBsAg) trajectories in persons with and without HBsAg loss on tenofovir‐containing antiretroviral therapy
Authors: Begré Lorin , Boyd Anders , Salazar‐Vizcaya Luisa , Suter‐Riniker Franziska , Béguelin Charles , Rockstroh Jürgen K. , Günthard Huldrych F. , Calmy Alexandra , Cavassini Matthias , Stöckle Marcel , Schmid Patrick , Bernasconi Enos , Levrero Massimo , Zoulim Fabien , Wandeler Gilles , Rauch Andri ,   the Swiss HIV Cohort Study (SHCS)
Published: October 2023

AbstractObjectivesImproving the understanding of the patterns of quantitative hepatitis B surface antigen (qHBsAg) trajectories associated with HBsAg loss is important in light of novel anti‐hepatitis B virus agents being developed. We evaluated long‐term qHBsAg trajectories in persons with HIV and HBV during tenofovir‐containing antiretroviral therapy in the Swiss HIV Cohort Study.MethodsWe included 29 participants with and 29 without HBsAg loss, defined as qHBsAg <0.05 IU/mL. We assessed qHBsAg decline during therapy in both groups and used agglomerative hierarchical clustering to identify different qHBsAg trajectory profiles in persons with HBsAg loss.ResultsThe median follow‐up time was 11.9 years (IQR 8.4–14.1), and the median time to HBsAg loss was 48 months (IQR 12–96). Among participants with HBsAg loss, 79% had a qHBsAg decline ≥1 log10 IU/mL 2 years after starting tenofovir. The trajectories in qHBsAg levels during tenofovir therapy were heterogeneous, characterized by five distinct profiles. Among participants without HBsAg loss, only 7% had a qHBsAg decline ≥1 log10 IU/ml after 2 years.ConclusionsMost persons with HIV who experienced HBsAg loss had an early decline in qHBsAg levels, with diverse trajectories during long‐term tenofovir therapy. In persons without HBsAg loss, qHBsAg levels remained remarkably stable over time.
(K0.5Bi0.5)(Mg1/3Nb2/3)O3‐modified Sr0.7Bi0.2TiO3 lead‐free ceramics for energy storage applications
Authors: Khan Murad Ali , Manan Abdul , Rehman Maqbool Ur , Khan Sami Ullah , Faisal Shah , Wazir Arshad Hussain , Alresheedi Faisal , Lanagan Michael T. 
Published: October 2023

AbstractIn the present study, Sr0.7Bi0.2TiO3 is mixed with [(K0.5Bi0.5)(Mg1/3Nb2/3)O3] to form a solid solution of [(1 − x)SBT–x(KB)(MNb), x = 0.02, 0.04, 0.06, 0.1]. From the XRD results, it is indicated that KB is the main substituent for SBT ceramic at the A‐site. The breakdown strength (BDS) of ceramic gradually increases with an increase in doping content and achieves a high value of 280 kV/cm for x = 0.06. In addition, the 0.94SBT–0.06(KB)(MNb) ceramic shows excellent temperature stability (−55 to 140°C), a high recoverable energy density (Wd)—2.6 J/cm3, and an efficiency (η)—88% at 280 kV/cm. Therefore, 0.94SBT–0.06(KB)(MNb) ceramic is one of the possible materials for energy storage capacitor applications.
Net‐shaping of advanced ceramic composites by gelcasting into precision molds made by rapid‐prototyping
Authors: Jeevankumar Pallagani , Rose Poly , Rajanikanth Ammanabrolu , Rajasekharan Thankappan Pillai , Seshu Bai Vummethala 
Published: October 2023

AbstractDense ceramic components of complex shapes are fabricated by combining the techniques of rapid prototyping and gelcasting (RPGC process). Free‐flowing slurries of ceramic powders are set into precision molds fabricated out of expanded polystyrene (EPS) from computer‐aided design files, employing subtractive manufacturing. The removal of the mold from gelled parts is often a serious problem when attempting to produce large and complex‐shaped products. The EPS molds have advantages over the commonly used acrylonitrile butadiene styrene (ABS) molds in this context. Process innovations led to easy demolding and near‐net shaping of components of large and complex geometries that required minimal machining. Fabrication of complex‐shaped products out of alumina with a density of 99%, flexural strength of 389 MPa, and fracture toughness of ∼3 MPa√m is demonstrated. The RPGC process is extended to fabricate composites of alumina and yttria‐stabilized zirconia (YSZ) with α‐alumina platelet inclusions, with enhanced fracture toughness. The components have exhibited uniform density across the body of large and complex‐shaped parts, uniform microstructures, and good mechanical properties. EPS molds are also cost effective for fabricating large parts. The process is generic, allows for easy design modifications to include corrections for shrinkage, and also enables uniform distribution of second phases.
Efficacy and safety of intravesical dimethyl sulfoxide treatment for patients with refractory Hunner‐type interstitial cystitis: Real‐world data postofficial approval in Japan
Authors: Akiyama Yoshiyuki , Niimi Aya , Nomiya Akira , Taguchi Satoru , Yamada Yuta , Sato Yusuke , Kawai Taketo , Yamada Daisuke , Kume Haruki , Homma Yukio 
Published: October 2023

AbstractObjectivesTo examine real‐world data regarding intravesical dimethyl sulfoxide (DMSO) therapy after official approval as a treatment for Hunner‐type interstitial cystitis (HIC) in Japan.MethodsThis single institution, retrospective observational study was conducted between 2021 and 2022 to evaluate the outcomes of 30 patients with refractory HIC who received intravesical DMSO therapy according to the approved standardized regimen: administration of DMSO every 2 weeks for a total of 12 weeks. Treatment outcomes were evaluated using a 7‐graded global response assessment scale, O'Leary and Sant's symptom and problem indices (OSSI/OSPI), the overactive bladder symptom score (OABSS), an 11‐point pain intensity numerical rating scale, quality of life (QOL) score, and frequency volume chart variables. Related complications were also documented.ResultsThe response rates at 2, 4, 6, 8, 10, and 12 weeks were 36.7%, 43.3%, 53.3%, 60.0%, 70.0%, and 70.0%, respectively. Compared with baseline, OSSI/OSPI, pain intensity, urinary frequency, and the QOL score improved significantly from 4 weeks of treatment. The OABSS score and functional bladder capacity also showed a tendency toward moderate improvement, but the difference was not significant. The mean duration of symptom relapse after termination of treatment was 6.4 ± 3.9 months. No patients discontinued treatment due to adverse events, although acute bladder irritation during infusion was noted in 21 patients (70%), which disappeared within 3 days.ConclusionsThis study verifies the safety, moderately durable efficacy, and tolerability of the standard intravesical treatment with DMSO for HIC in Japan.
Subjective well‐being of older migrants in the Netherlands: A conceptual and methodological discussion
Authors: Conkova Nina , Fokkema Tineke , van Tilburg Theo G. 
Published: October 2023

AbstractSocial policy is most effective when evidence‐based. In this research, we scrutinise 11 surveys to produce evidence on the subjective well‐being (SWB) of older migrants in the Netherlands. The descriptive analysis and literature review revealed that the study of the diversity among older migrants is hindered by several factors, including the inclusion of a limited number of distinct migrant groups, their almost exclusive comparison to non‐migrants, and a focus on first‐generation and urban‐based migrants. Different concepts are used for three dimensions of SWB, both migrant‐specific and general. The validity of concepts and measurement instruments is not well examined. By means of multi‐group analysis, we demonstrate that the overarching concept of SWB is multidimensional and cannot be easily used to compare different groups of migrants. In conclusion, we argue that survey data can be used to further refine the concept of SWB, compare differences between and within migrant groups and over time, and ultimately inform social policy better.
The role of digital literacy in satisfaction with online migration services in Ghana: A cross‐sectional survey
Authors: Bokpin Hayford Alufar , Akakpo Martin Gameli 
Published: October 2023

AbstractLike in many other fields of human endeavour, digital literacy is rising in importance. As migration continues unabated, key stages of the process are now possible online. This study investigated the role of digital literacy and migration intent in satisfaction with online migration services. Deploying a cross‐sectional survey of 100 students at a Ghanaian university, the study tested the hypotheses with a linear regression (r = 0.85, R‐square = 0.72, p = 0.00). Results indicate support for digital literacy and migration intent in satisfaction with online migration services. Age and level of education are correlated with satisfaction, digital literacy and migration intent. The meaning and implications of these findings are discussed.
The impact of a music enrichment program during infancy and early toddlerhood on effortful control at age 3: A preliminary investigation
Authors: Smith Amy R. , McGregor Casey M. , Carr Katelyn , Epstein Leonard H. , Serwatka Catherine , Paluch Rocco , Piazza Jacqueline , Shisler Shannon , Kong Kai Ling 
Published: October 2023

AbstractEffortful control (EC), a self‐regulation skill, is associated with long‐term developmental outcomes. Music has been associated with infant self‐regulation and may be an intervention strategy for enhancing EC during toddlerhood. This investigation included 32 parent‐child dyads from a previously conducted randomized controlled trial (RCT). Participants (9‐15‐months old at baseline) attended either a music enrichment program or a playdate control once a week for 1 year and monthly for an additional year. At age 3, participants completed snack and gift delay effortful control tasks. Groups were compared using one‐way ANOVA. We found that participants in the music group had a significantly higher score during snack delay (music mean = 3.47 ± 0.94; control mean = 2.45 ± 1.51; p = 0.03; Cohen's d = 0.84). We did not find a significant group difference for latency to peek (music mean = 39.10 ± 20.10; control mean = 30.90 ± 19.88; p = 0.25; d = 0.57) or latency to touch (music mean = 105.73 ± 417.69; control mean = 98.35 ± 28.84; p = 0.38; d = 0.29) for the gift task. This study provides initial evidence that early participation in a music enrichment program may benefit later development of EC. This study is registered at ClinicalTrials.gov (NCT02936284).
Evaluating psychometric properties of three mentoring scales among nurses and midwives in hospital settings: A methodological study
Authors: Kakyo Tracy Alexis , Xiao Lily Dongxia , Chamberlain Diane 
Published: October 2023

AbstractBackgroundScales used to evaluate nurses’ perspectives of mentoring programmes are mainly designed in developed countries, making them unsuitable for nurses and midwives working in resource‐poor developing countries.AimTo explore the psychometric properties of the perceived cost of mentoring (PCM) scale, negative mentoring experiences (NME) scale and relational mentoring index (RMI) for adaptation in hospital settings in Uganda.MethodsA cross‐sectional study design was used. In total, 303 hospital nurses/midwives in Ugandan participated in the study to evaluate the psychometric properties of the three mentoring scales.ResultsRevisions based on word choice were made in adapting the scales to the Ugandan context. The PCM showed three factors (risk to reputation, mentoring effort and nepotism) and had an intra‐class correlation (ICC) of 0.609 (95% CI, 0.324–0.793) and Cronbach's alpha of 0.705. The NME scale had two factors (lack of mentor expertise and mismatch between the dyad) consistent with the original scale with an ICC of 0.568 (95% CI, 0.271–0.767) and Cronbach's alpha of 0.841. The RMI showed two factors (individual influence and relational quality) with an ICC of 0.664 (95% CI, 0.410–0.824) and Cronbach's alpha of 0.933.ConclusionsThe initial psychometric assessment indicates satisfactory validity and reliability of the scales for implementation among nurses and midwives within Ugandan hospital contexts. Subsequent research is warranted to validate the factor structures of the scales on a different sample.Implications for nursing and health policyIn using mentoring programmes to develop the hospital workforce, nurse and midwifery policymakers need to use culturally adapted and validated PCM, NME, and RMI scales to evaluate the quality of these mentoring programmes to maximise the benefits while avoiding unintended consequences.
Nurse practitioner affecting systems change in the context of a LEADS leadership framework: Experience from the field
Authors: Diaczun Tessa , Miller Minna K 
Published: October 2023

AbstractAimThis paper highlights a new role of Advanced Practice Nurse/Nurse Practitioner as the clinical planning lead in the development of a unique model of care and service delivery for children living with health complexity, in the context of a LEADS leadership framework and related capabilities.BackgroundThe LEADS in a Caring Environment Framework is an effective tool for leadership development and systems change. An experienced Advanced Practice Nurse/Nurse Practitioner hired into a leadership role contributes to system change for a complex population across a large geographic area.Sources of evidenceWorld Health Organization, Canadian Nurses Association and other websites, academic databases (PubMed and CINAHL) and relevant books were explored, and the expertise and knowledge of the authors and the redevelopment project team were utilized.DiscussionThe Advanced Practice Nurse/Nurse Practitioner (first author) shares and reflects on her own lived experience as a leader in the planning for programmes and services at the new centre utilizing the five LEADS domains and related capabilities.ConclusionThe utilization of the LEADS in a Caring Environment Capabilities Framework showcases the strengths and skills of an Advanced Practice Nurse/Nurse Practitioner shifting from direct clinical care to successfully leading system‐level change. By incorporating the LEADS framework into practice, in any setting or role, Advanced Practice Nurse/Nurse Practitioners can both evaluate and develop their leadership skills while positively effecting system transformation.Implications for nursing practiceThe LEADS framework fosters ongoing professional development and can be used to measure the added value of Advanced Practice Nurses within an organization.Implications for nursing policyAdvanced Practice Nurses improve outcomes within the health care system. Leaders must consider this evidence in health workforce planning, ensuring that Advanced Practice Nursing roles become fully integrated and are supported in the context of national and regional health systems.