bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mortality experience of disabled persons in the United States during the COVID-19 pandemic
Authors: Weaver David A 
Published: December 2023

Abstract
New data from the Social Security Administration suggest there were 260 000 excess deaths in the United States among current or former disability beneficiaries during the first 22 months of the COVID-19 pandemic. These beneficiaries accounted for 26% of all excess deaths in the United States during this period. The pattern of deaths among disabled beneficiaries corresponds closely to known milestones in the pandemic's history. Disabled beneficiaries in New York, particularly those residing in institutions, had extremely elevated mortality with the onset of the pandemic in the spring of 2020. Across all regions in the United States, mortality among disability beneficiaries increased sharply with the onset of the winter of 2020–2021 and with the emergence of the Delta and Omicron variants in 2021. Elevated mortality was observed for persons with intellectual, mental, and physical impairments. Future public information campaigns about vaccines and other measures may be more successful if they include specific efforts to directly target disability beneficiaries. In addition, clinical trials and other research should consider including disabled persons as specific study groups as the severity of their underlying health impairments is likely comparable to that of persons of advanced age.
Inducing a summer brood break increases the efficacy of oxalic acid vaporization for Varroa destructor (Mesostigmata: Varroidae) control in Apis mellifera (Hymenoptera: Apidae) colonies
Authors: Berry Jennifer A , Braman S Kris , Delaplane Keith S , Bartlett Lewis J 
Published: December 2023

Abstract
The ectoparasitic mite, Varroa destructor (Anderson and Trueman), is the leading cause of western honey bee colony, Apis mellifera (L.), mortality in the United States. Due to mounting evidence of resistance to certain approved miticides, beekeepers are struggling to keep their colonies alive. To date, there are varied but limited approved options for V. destructor control. Vaporized oxalic acid (OA) has proven to be an effective treatment against the dispersal phase of V. destructor but has its limitations since the vapor cannot penetrate the protective wax cap of honey bee pupal cells where V. destructor reproduces. In the Southeastern United States, honey bee colonies often maintain brood throughout the year, limiting the usefulness of OA. Prior studies have shown that even repeated applications of OA while brood is present are ineffective at decreasing mite populations. In the summer of 2021, we studied whether incorporating a forced brood break while vaporizing with OA would be an effective treatment against V. destructor. Ninety experimental colonies were divided into 2 blocks, one with a brood break and the other with no brood break. Within the blocks, each colony was randomly assigned 1 of 3 treatments: no OA, 2 g OA, or 3 g OA. The combination of vaporizing with OA and a forced brood break increased mite mortality by 5× and reduced mite populations significantly. These results give beekeepers in mild climates an additional integrated pest management method for controlling V. destructor during the summer season.
Review: the risks of spray adjuvants to honey bees
Authors: Shannon Brandon , Jeon Hongyoung , Johnson Reed M 
Published: December 2023

Abstract
Pesticide applications are often made as tank mixes containing multiple pesticide products and may include spray adjuvants to enhance pesticidal activities. The primary aim of adjuvant products is to increase the spreading and sticking of spray droplets and to increase the penetration of active ingredients through the cuticles of leaves or targeted pests, which can reduce the amount of active ingredient needed for effective pest control. Adjuvants are made up of compounds drawn from the “inert ingredient” list maintained by EPA but are identified as “principal functioning agents” when used in adjuvant products. These inert compounds do not undergo the same testing and risk assessment process that is required of pesticide active ingredients and generally have no mitigation measures that prevent application onto crops during bloom at times of day when bees are foraging. Honey bees (Apis mellifera;Hymenoptera:Apidae) are at an increased risk of exposure to adjuvant tank mixtures while providing agricultural pollination services. Colony losses attributed to pesticide applications thought to have low risk to honey bees have been reported, highlighting the need to better understand the toxicity of adjuvants included in pesticide tank mixtures. This review summarizes current literature on the risks posed to honey bees by agricultural adjuvants and tank mix combinations of adjuvants with pesticides. Based on the current state of knowledge, we make recommendations to pesticide applicators, product manufacturers, regulatory agencies, and researchers regarding adjuvant toxicity to honey bees with the goal of reducing risks that adjuvants pose to honey bees and other beneficial insects.
Immature stages of Phloeosinus tacubayae (Curculionidae: Scolytinae): morphology and chaetotaxy of larva and pupa, sexual dimorphism of adults, and developmental time
Authors: Cervantes-Espinoza Montserrat , Alejandro Ruiz Enrico , Cuellar-Rodríguez Gerardo , Castro-Valderrama Ulises , Armendáriz-Toledano Francisco 
Published: December 2023

Abstract
The current knowledge of morphology and chaetotaxy of the different developmental stages within the subfamily Scolytinae presents an information deficit that needs to be addressed. Thus, the objective of the present study was to describe, the chaetotaxy and morphology of larvae and pupae, and determine the number of larval instars, the sexual dimorphism in adults, and the development time in Phloeosinus tacubayae. The number of larval instars was determined using traditional morphometry of cephalic capsule and multivariate analysis; description of morphology and chaetotaxy of larvae and pupae, and sexual dimorphism in adults was based on light microscopy and scanning electron microscopy photographs; finally, we quantified development time by mean reviews of 10 gallery systems selected randomly in infested logs, in the laboratory. Morphometric analysis of the cephalic capsule allowed the recognition of 3 different instars. Our results showed that the larvae of P. tacubayae have unique attributes in the body that differentiate them from other genera of the subfamily for example the epicranial suture is not marked, and differentiated from Phloeosinus canadensis, such as a smaller number of setae in the maxillae and without a tergal plate. The pupa had a smaller number of setae on the whole body. The most useful morphological characters to identify a sexual dimorphism in adults were found in the shape and relative position of the seventh and eighth tergites; development time lasted 40 days in total, being the pupal stage the one that took the longest to complete.
Cosmic metallicity evolution of Active Galactic Nuclei: implications for optical diagnostic diagrams
Authors: Dors Oli L , Cardaci M V , Hägele G F , Ilha G S , Oliveira C B , Riffel R A , Riffel R , Krabbe A C 
Published: December 2023

ABSTRACT
We analyse the validity of optical diagnostic diagrams relying on emission-lines ratios and in the context of classifying Active Galactic Nuclei (AGNs) according to the cosmic metallicity evolution in the redshift range $0 \le z \le 11.2$. In this regard, we fit the results of chemical evolution models (CEMs) to the radial gradients of the N/O abundances ratio derived through direct estimates of electron temperatures (Te-method) in a sample of four local spiral galaxies. This approach allows us to select representative CEMs and extrapolate the radial gradients to the nuclear regions of the galaxies in our sample, inferring in this way the central N/O and O/H abundances. The nuclear abundance predictions for theoretical galaxies from the selected CEMs, at distinct evolutionary stages, are used as input parameters in AGN photoionization models built with the Cloudy code. We found that standard BPT diagnostic diagrams are able to classify AGNs with oxygen abundances $\rm 12+\log (O/H) \gtrsim 8.0$ [$(Z/Z_{\odot }) \gtrsim 0.2$] at redshift $z \lesssim 4$. On the other hand, the He iiλ4685/Hβ versus [N ii]λ6584/Hα diagram produces a reliable AGN classification independent of the evolutionary stage of these objects.
Machine-learning applications for cataclysmic variable discovery in the ZTF alert stream
Authors: Mistry D , Copperwheat C M , Darnley M J , Olier I 
Published: December 2023

ABSTRACT
Cataclysmic variables (CV) encompass a diverse array of accreting white dwarf binary systems. Each class of CV represents a snapshot along an evolutionary journey, one with the potential to trigger a type Ia supernova event. The study of CVs offers valuable insights into binary evolution and accretion physics, with the rarest examples potentially providing the deepest insights. However, the escalating number of detected transients, coupled with our limited capacity to investigate them all, poses challenges in identifying such rarities. Machine learning (ML) plays a pivotal role in addressing this issue by facilitating the categorization of each detected transient into its respective transient class. Leveraging these techniques, we have developed a two-stage pipeline tailored to the Zwicky Transient Facility transient alert stream. The first stage is alerts filter aimed at removing non-CVs, while the latter is an ML classifier produced using Extreme Gradient Boosting, achieving a macro average area under the curve score of 0.92 for distinguishing between CV classes. By utilizing the generative topographic mapping algorithm with classifier posterior probabilities as input, we obtain representations indicating that CV evolutionary factors play a role in classifier performance, while the associated feature maps present a potent tool for identifying the features deemed most relevant for distinguishing between classes. Implementation of the pipeline in 2023 June yielded 51 intriguing candidates that are yet to be reported as CVs or classified with further granularity. Our classifier represents a significant step in the discovery and classification of different CV classes, a domain of research still in its infancy.
Molecular mechanism of specific DNA sequence recognition by NRF1
Authors: Liu Ke , Li Weifang , Xiao Yuqing , Lei Ming , Zhang Ming , Min Jinrong 
Published: December 2023

Abstract
Nuclear respiratory factor 1 (NRF1) regulates the expression of genes that are vital for mitochondrial biogenesis, respiration, and various other cellular processes. While NRF1 has been reported to bind specifically to GC-rich promoters as a homodimer, the precise molecular mechanism governing its recognition of target gene promoters has remained elusive. To unravel the recognition mechanism, we have determined the crystal structure of the NRF1 homodimer bound to an ATGCGCATGCGCAT dsDNA. In this complex, NRF1 utilizes a flexible linker to connect its dimerization domain (DD) and DNA binding domain (DBD). This configuration allows one NRF1 monomer to adopt a U-turn conformation, facilitating the homodimer to specifically bind to the two TGCGC motifs in the GCGCATGCGC consensus sequence from opposite directions. Strikingly, while the NRF1 DBD alone could also bind to the half-site (TGCGC) DNA of the consensus sequence, the cooperativity between DD and DBD is essential for the binding of the intact GCGCATGCGC sequence and the transcriptional activity of NRF1. Taken together, our results elucidate the molecular mechanism by which NRF1 recognizes specific DNA sequences in the promoters to regulate gene expression.
Starch phosphorylation regulates starch granule morphological homogeneity in Arabidopsis thaliana
Authors: Li Xiaoping , Ahmad Abubakar Musa , Zhong Yuyue , Ding Li , Blennow Andreas , Fettke Joerg 
Published: December 2023

Abstract
Starch granule morphological homogeneity presents a gap in starch research. Transitory starch granules in wild-type plants are discoid, regardless of species. Notably, while the shape of starch granules can differ among mutants, it typically remains homogeneous within a genotype. We found an Arabidopsis thaliana mutant, dpe2sex4, lacking both the cytosolic disproportionating enzyme 2 (DPE2) and glucan phosphatase SEX4, showing an unprecedented bimodal starch granule diameter distribution when grown under a light/dark rhythm. dpe2sex4 contained 2 types of starch granules: large granules and small granules. In contrast to the double starch initiation in wheat (Triticum aestivum) endosperm, where A-type granules are initiated first and B-type granules are initiated later, dpe2sex4 small and large granules developed simultaneously in the same chloroplast. Compared with the large granules, the small granules had more branched amylopectin and less surface starch-phosphate, thus having a more compact structure that may hinder starch synthesis. During plant aging, the small granules barely grew. In in vitro experiments, fewer glucosyl residues were incorporated in small granules. Under continuous light, dpe2sex4 starch granules were morphologically homogeneous. Omitting the dark phase after a 2-wk light/dark cycle by moving plants into continuous light also reduced morphological variance between these 2 types of granules. These data shed light on the impact of starch phosphorylation on starch granule morphology homogeneity.
Assessing Admiration for Women Who Do “Men’s Work”
Authors: Pike Isabel , Pierotti Rachael S , Mbaye Mame Soukeye 
Published: December 2023

Abstract
Drawing on interviews and focus groups from Conakry, the capital city of the Republic of Guinea in West Africa, this article examines how people talk about women working in male-dominated skilled trades alongside women’s accounts of their work experiences in those sectors. We find that the idea of women doing gender atypical work, whom we call “crossovers,” evokes widespread admiration. They are unanimously described as brave and virtuous, contrasted with women who rely on money from relationships with men. However, this celebration falters in the workplace, where crossovers often experience paternalism and harassment. Building on theories of both gender beliefs and femininities, we attribute this discrepancy to the differential threats to the gender order that are posed by accommodating crossovers at work versus speaking positively about them. Working together requires men to confront actual women’s unexpected capabilities, while rhetorically celebrating crossovers may in fact reify stereotypes about most women and fail to fundamentally undermine men’s authority. Crossovers can serve as sources of inspiration for an alternative gender order, but we find that professed admiration for “exceptional” groups of women has both limitations and risks. We conclude by suggesting that the subversive potential of admiration for gender atypical behavior must be empirically examined, rather than assumed, with attention to why such women are seen as admirable as well as how this admiration is borne out in social interactions.
Gas Humidification During Helmet Continuous Positive Airway Pressure
Authors: Ambrosetti Lorenzo , Giani Marco , Rezoagli Emanuele , Fiorillo Chiara , Vitale Daniela , Giacchè Damiano , Ravasio Giambattista , Fumagalli Roberto , Foti Giuseppe , Lucchini Alberto 
Published: December 2023

Background
In the last decades, the use of the helmet interface to deliver noninvasive respiratory support has steadily increased. When delivering oxygen therapy, conditioning of inspired gas is mandatory, as the water content of medical gas is neglectable. To minimize the risk of airway damage, it is recommended to achieve an absolute humidity greater than 10 mg H2O/L. The primary aim of the study was to assess the performance of 3 different heated humidifiers to condition gas during helmet continuous positive airway pressure and to compare them with a setting without active humidification.

Methods
We performed a crossover randomized physiological study in healthy volunteers. Absolute humidity, relative humidity, and temperature were measured during 4 steps (no humidification and the 3 heated humidifiers, performed in a randomized order) and at 3 time points (after 1, 5, and 10 minutes).

Results
Eight subjects participated to the study. Without active humidification, absolute humidity was constantly below the recommended level. All humidifiers conditioned the inspired gases to an average absolute humidity greater than 10 mg H2O/L. Overall, the best performance, in terms of absolute humidity, was obtained with H900 (19.74 ± 0.50 mg H2O/L), followed by TurbH2O (−6.82 mg H2O/L vs H900; 95% confidence interval, −8.49 to −5.14; P < .05) and F&P 810 (−9.03 mg H2O/L vs H900; 95% confidence interval, −10.70 to −7.35; P < .05).

Conclusions
Active humidification is required to achieve adequate conditioning of inspired gas during helmet continuous positive airway pressure. The choice between different humidifiers available on the market should be made according to the local needs and expertise.
HCC is associated with diabetes and longitudinal blood glucose control in a national cohort with cirrhosis
Authors: Mezzacappa Catherine , Mahmud Nadim , Serper Marina , John Binu V. , Taddei Tamar H. , Kaplan David E. 
Published: December 2023

Background:
Diabetes is associated with HCC; however, the impact of longitudinal blood glucose (BG) control on HCC risk in cirrhosis is not well known. We investigated this knowledge gap in a cohort of United States Veterans with cirrhosis from 2015 to 2021.

Methods:
We used repeated hemoglobin A1c measurements to categorize follow-up time according to BG control (defined as hemoglobin A1c < 7%) state over time: uncontrolled, nonsustained control (≤2 y), or sustained control (>2 y). We performed a sensitivity analysis using hemoglobin A1c < 8% to define BG control. We used Fine and Gray Cox proportional hazards regression with death and transplant as competing events to compare rates of incident HCC.

Results:
Our study included 81,907 individuals, 56.2% of whom had diabetes at baseline. There were 8,002 incident HCCs. The rate of HCC was 18% higher in diabetes (95% CI: 13% – 24%), and the relative increase in the rate of HCC varied by etiology of cirrhosis from nonsignificant (HCV) to an increase of 120% (HBV). Uncontrolled and nonsustained BG control was associated with 1.80 (95% CI: 1.70–1.91) and 2.34 (95% CI: 2.21–2.48) times the rate of HCC compared to sustained BG control, respectively. Using Hgb A1c < 8% to define BG control, HCC rates in uncontrolled and nonsustained BG control were 2.43 (2.28–2.58) and 2.23 (2.11–2.36) times that observed in sustained BG control.

Conclusions:
Associations between diabetes and HCC in cirrhosis vary according to the longitudinal BG control state. Inadequate BG control is consistently associated with a higher risk of HCC, and long-term BG control should be considered in comprehensive cirrhosis care.
Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage
Authors: Srinivasan Amudan J. , Secunda Zachary A. , Mota-Alvidrez Roberto I. , Luc Norman F. , Disharoon Dante , Traylor Baylee , Pawlowski Christa L. , Brown Joshua B. , Bruckman Michael A. , Gupta Anirban Sen , Neal Matthew D. 
Published: December 2023

BACKGROUND
Early platelet transfusion is associated with reduced mortality in traumatic hemorrhage. However, platelet usage is severely limited because of the challenges of donor availability, platelet portability, and storage. Here, we report on a bioinspired synthetic platelet (SP) nanoconstruct that utilizes liposome surface-decoration with peptides that mimic injury site-specific platelet adhesion to von Willebrand Factor and collagen, and fibrinogen-mediated platelet aggregation. Synthetic platelet has previously shown promising hemostatic outcomes in vitro and in vivo. Here, we evaluated hemostasis and hemodynamic effects of SP in a rabbit model of abdominal hemorrhage.

METHODS
Twenty-three adult male New Zealand white rabbits (2.5–3.5 kg) were treated with either buffer, control particles (CPs), or SP. Under general anesthesia with invasive monitoring, rabbits underwent laparotomy with combined splenic and hepatic injury. Hemodynamics were monitored for 30 minutes and blood loss was quantified. Blood counts, aggregometry, catecholamine and platelet factor 4 (PF4) assays were performed at multiple timepoints. Analysis used analysis of variance and post hoc Tukey testing with α = 0.05.

RESULTS
Rabbits in the SP (n = 7) group had significantly lower weight-normalized blood loss compared with both buffer (n = 8) and CP (n = 8) animals (21.1 vs. 33.2 vs. 40.4 g/kg, p < 0.001). Synthetic platelet–treated animals had higher systolic blood pressure area under curve compared with buffer- and CP-treated animals (1567 vs. 1281 vs. 1109 mm Hg*min, p = 0.006), although post hoc differences were only significant for the SP/CP comparison (p = 0.005). Platelet counts, catecholamine levels, PF4, and aggregometry were similar between groups.

CONCLUSION
Synthetic platelet treatment significantly reduced blood loss and improved hemodynamics in a rabbit abdominal hemorrhage model. Synthetic platelet has potential as an intravenous hemostatic platelet surrogate with donor-independent availability and scalable manufacture.
SAN: mitigating spatial covariance heterogeneity in cortical thickness data collected from multiple scanners or sites
Authors: Zhang Rongqian , Chen Linxi , Oliver Lindsay D. , Voineskos Aristotle N. , Park Jun Young 
Published: December 2023

AbstractIn neuroimaging studies, combining data collected from multiple study sites or scanners is becoming common to increase the reproducibility of scientific discoveries. At the same time, unwanted variations arise by using different scanners (inter-scanner biases), which need to be corrected before downstream analyses to facilitate replicable research and prevent spurious findings. While statistical harmonization methods such as ComBat have become popular in mitigating inter-scanner biases in neuroimaging, recent methodological advances have shown that harmonizing heterogeneous covariances results in higher data quality. In vertex-level cortical thickness data, heterogeneity in spatial autocorrelation is a critical factor that affects covariance heterogeneity. Our work proposes a new statistical harmonization method called SAN (Spatial Autocorrelation Normalization) that preserves homogeneous covariance vertex-level cortical thickness data across different scanners. We use an explicit Gaussian process to characterize scanner-invariant and scanner-specific variations to reconstruct spatially homogeneous data across scanners. SAN is computationally feasible, and it easily allows the integration of existing harmonization methods. We demonstrate the utility of the proposed method using cortical thickness data from the Social Processes Initiative in the Neurobiology of the Schizophrenia(s) (SPINS) study. SAN is publicly available as an R package.