bluuebunny/crossref_metadata_2025_split huggingface dataset:
The involvement of cytokines in the prophylactic effect of duloxetine on indomethacin-induced gastric ulcer
Authors: Ding Hongwan , Wang Ying , Gao Yinge , Ye Fan , Yao Kai , Cao Linyu , Liu Zix , 王 贵彬 , Zhang Jianjun 
Published: December 2023

Abstract
Gastric ulcer is a common and global disease with high recurrence rate. It has been shown that selective serotonin-norepinephrine reuptake inhibitor duloxetine had protective effect on indomethacin-induced gastric ulcer, which was escorted by inflammation in the gastric mucosa. Cytokines, small-molecule peptides secreted from a variety of cells, are the principal mediators of inflammation. By screening the differential expression of cytokines in the gastric mucosa using cytokine array, we found that indomethacin induced increase in cytokines which promoted inflammation responses, whereas the protective effect of duloxetine was mediated through correcting the imbalance between pro-inflammatory cytokines and anti-inflammatory cytokines in gastric mucosa. Among them, RANTES was a key mediator in the prophylactic effect of duloxetine against indomethacin. We further identified that the protection was mediated by RANTES-chemokine receptor type 5 (CCR5) axis and inhibition of the axis by Met-Rantes or a CCR5 antagonist maraviroc suppressed the protection of duloxetine. Considering the pharmacologic action of duloxetine on reuptake of monoamine neurotransmitters, we examined the serotonin, norepinephrine and dopamine contents in the blood and discovered 20 mg/kg duloxetine increased serotonin levels in platelet-poor plasma, thus promoting expression of RANTES in gastric mucosa. Furthermore, increased RANTES activated PI3K-AKT-VEGF signaling pathway, which may be attributed to the protective effect of VEGF on endothelial cells and vessels in gastric mucosa. Together, our results identified the role of cytokines, particularly RANTES, and the underlying mechanisms in protection of duloxetine against indomethacin-induced gastric ulcer, which advanced our understanding in inflammatory modulation by monoamine-based antidepressant.
Knowledge, attitudes, and practices among caregivers of children with epilepsy in outpatient pediatric neurology clinic: a cross-sectional study at Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia
Authors: Negussie Absalat Serawit , Dehan Mansour Fayz , Mekonnen Samuel Ayalew , Zelleke Tesfaye Getaneh 
Published: December 2023

Abstract

Background: Caregivers' knowledge and attitudes significantly impact epilepsy care, influencing help-seeking behavior and treatment decisions. In Ethiopia, epilepsy is often misunderstood, associated with misconceptions, and accompanied by persistent negative attitudes. The objective of this study is to assess the knowledge, attitude, and practice of caregivers of children with epilepsy
Methods: A hospital-based cross-sectional study was conducted. A total of 120 caregivers were interviewed using a pretested structured questioner. Data were analyzed using SPSS version 23. Descriptive and analytical statistical procedures, with 95% confidence interval were employed and significance level was determined at p-value < 0.05.
Results: A significant proportion of the caregivers were familiar with the term 'epilepsy', with more than half having heard or read about it (62; 51.7%) or knowing someone other than the child with epilepsy (61; 50.8%). The identified causes of epilepsy varied, with birth injury 44 (36.7%) being the most common cause reported by caregivers. Notably, there were associations between caregiver sex, awareness of epilepsy through hearing or reading, knowing someone with epilepsy, and their level of knowledge about epilepsy. The study also revealed negative attitudes toward epilepsy. More than half of the participants (56.7%) believed that a child with epilepsy cannot have a high level of intelligence, the majority (76.7%) would not allow their child to play with a child who has epilepsy, and 39.1% believed that a child with epilepsy should never attend school. Additionally, a significant number of caregivers resorted to traditional treatments 35 (29%). A considerable percentage of children with epilepsy received alternative treatments (85 [70%] along with antiepileptic medications). The majority of caregivers recognized the importance of seeking medical attention for individuals with epilepsy.
Conclusions: A significant knowledge gap was identified among caregivers of children with epilepsy, revealing prevalent misconceptions and negative attitudes. Improving the epilepsy knowledge, attitude, and practice gap in caregivers will potentially contribute to overall improved awareness, as caregivers can serve as resources and advocates for people with epilepsy.
The Impact of Customer Service Quality on Customer Satisfaction: A study on Bangladeshi Banks
Authors: Anika Afrin , Islam Mahia , Ahmed Farhad 
Published: December 2023

Abstract
This research study examines the impact of customer service quality on customer satisfaction at Bangladeshi Banks. The study aimed to fill existing gaps in understanding the correlation between customer service quality and customer satisfaction in the banking sector, specifically within the context of this bank. The research design adopted for this study was qualitative, allowing for an in-depth exploration of participants' perspectives and experiences. Semi-structured interviews were conducted with key bank representatives and customers to gather rich and contextualized data. The findings from the study shed light on the critical factors influencing customer satisfaction. Responsive service, efficiency in service delivery, and personalization emerged as key drivers of customer satisfaction. Customers highly value prompt and effective responses to their inquiries and seek quick and hassle-free transactions. Personalized services that cater to individual needs and preferences were found to enhance customer perceptions and foster stronger relationships. Additionally, the study highlighted the importance of effective complaint resolution in influencing customer satisfaction. Respondents emphasized the significance of handling complaints with empathy and efficiency to turn dissatisfied customers into loyal advocates. Communication also played a vital role in customer interactions. Clear and prompt communication of information regarding banking products, services, and policies positively impacted customer satisfaction. Furthermore, the study identified a strong link between customer service quality and overall customer satisfaction with Bangladeshi Banks. Positive customer service experiences contributed to higher levels of satisfaction, while negative experiences had the potential to lead to dissatisfaction and affect the bank's reputation. Based on the findings, several recommendations were provided to enhance customer service quality and improve overall customer satisfaction. These recommendations included strengthening responsiveness, investing in customer service training, streamlining processes, leveraging technology, offering personalized services, acting on customer feedback, and fostering a customer-centric culture. This study underscores the critical role of customer service quality in shaping customer satisfaction and loyalty in the banking sector. By prioritizing customer service excellence and implementing the provided recommendations, Bangladeshi Banks can enhance customer relationships, drive loyalty, and establish itself as a customer-centric institution in the competitive banking market. The insights from this study have implications for the bank's strategic decision-making processes and long-term success in delivering exceptional customer experiences.
Optimizing Segmentation Strategies: Self-Supervised Methods for COVID-19 Imaging
Authors: Gao Yuan , Geng Dehua , Xu Longwei , Hua Qianqian , Wang Pengwei 
Published: December 2023

Abstract
The segmentation of COVID-19 lesions can aid in the diagnosis and treatment of COVID-19. Due to the lack of rich labelled datasets and a comprehensive analysis of representation learning for COVID-19, few studies exist in this field. In order to address the aforementioned issues, we propose a self-supervised learning scheme for COVID-19 using unlabeled COVID-19 data in order to investigate the significance of pre-training for this task. We have significantly improved the pre-training performance of the model by effectively leveraging unlabeled data and implementing a variety of pretraining strategies. In addition, the performance of the self-supervised model has been enhanced by the integration of the channel-wise attention mechanism module, the Squeeze-and-Excitation (SE) block, into the network architecture. Experiments demonstrate that our model performs better than other SOTA models on the publicly available COVID-19 medical image segmentation dataset.
Electric Vehicle Accidents Attitude Scale (EVAAS) for Healthcare Professionals: Reliability and Validity Study
Authors: KAYHAN Uğur , LİMAN Zafer , ÖZDİNÇ Şerife , KILIÇ İbrahim 
Published: December 2023

Abstract
Background/aim: Although traffic accidents are an important public health problem, reducing mortality and morbidity is directly related to the knowledge, attitudes and behaviors of healthcare professionals. Investigating the causes of injury and death in vehicle accidents has gained importance with the development of electric vehicle technology in recent years. These issues are directly or indirectly under the responsibility of forensic medicine. The aim of this study is to develop an Electric Vehicle Accidents Attitude Scale (EVAAS) regarding cognitive, affective and behavioral dimensions to determine the attitudes of healthcare professionals towards electric vehicle accidents.
Materials and methods: The sample group of the study consisted of 386 physicians, paramedics, emergency medicine technicians and ambulance drivers working in the emergency services and 112 units of public state and university hospitals in Türkiye. The Delphi technique including expert opinions was utilized in the development of EVAAS and validity and reliability analyses were carried out after a focus group study and pilot application process were completed.
Results: The 27-item EVAAS was grouped under 3 dimensions-factor- (cognitive, affective, and behavioral) explaining 65.257% of the total variance. Cronbach's Alpha coefficient for EVAAS was 0.859, retest reliability was 0.781, and the test-retest reliability was calculated as 0.766 (Table 2).
Conclusion: A valid and reliable EVAAS consisting of 27 items in three dimensions: cognitive, affective and behavioral was developed in the study.
Investigation of Colistin Utilization in the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Bloodstream Infections in Children and Literature Review
Authors: Geniş Cankat , Kaman Ayşe , Öztürk Betül , Tanır Gönül 
Published: December 2023

Abstract
Objective: This retrospective study aimed to assess the effectiveness and safety of combined colistin therapy in treating nosocomial infections caused by multi-drug resistant gram-negative pathogens in pediatric patients.
Materials and Methods: 45 pediatric patients who received intravenous colistin for healthcare-associated infections at Dr. Sami Ulus Training and Research Hospital between January 2015 to 2020 were included. Patient-specific detailed clinical information, prognoses, and laboratory findings on days 1, 3, and 7 of colistin treatment were obtained from medical records
Results: Among the patients, 26 [57.8%] were male and 19 [42.2%] were female, with a median age of 18 months. Clinical and microbiological responses were observed in 37 patients [82.2%], while two patients [4.4%] discontinued colistin due to side effects without assessing treatment response. Six patients [13.3%] did not achieve clinical and microbiological response and succumbed to the infection. Nephrotoxicity was the most common side effect, occurring in eight patients on the third day of treatment. One patient with nephrotoxicity had underlying chronic renal failure.
Conclusion: Combined colistin therapy is effective and safe for treating nosocomial infections caused by multi-drug resistant gram-negative bacteria in pediatric patients, which often have high mortality rates and limited treatment options.
Synergistic effect of Fe-amorphous and bionic microtexture in enhancing high-temperature tribological properties of Al-12Si piston materials
Authors: Wang Yingdong , Lin Zuxiang , Yin Chengbin , Kong Detong , Zhao Deyong , Wang Zhijun , Ma Beibei , Xu Zehua , Wang Yuan 
Published: December 2023

Abstract
The objective of this study is to enhance the friction properties of piston materials under high temperatures. To achieve this, we developed a novel piston composite material (Fe-amorphous/Al-12Si) by incorporating Fe-amorphous. Additionally, we employed bionic micro-textured laser surface treatment technology to improve its wear resistance. The influence of Fe-amorphous content on the frictional properties of the composite material was investigated, together with the synergistic mechanism of Fe-amorphous addition and biomimetic texture on Al-12Si under the lubrication conditions of B30 biodiesel diluted engine oil. The results indicate that the frictional properties of the untextured surface of the Fe-amorphous/Al-12Si composite material depend primarily on the amount of Fe-amorphous added. The 10 wt% Fe-amorphous/Al-12Si composite exhibits a dense, void-free microstructure with optimum anti-friction and anti-wear performance. It is noteworthy that the interaction between the "anchoring effect" caused by the Fe-amorphous addition and the "fluid-dynamic lubrication effect" induced by the biomimetic texture further enhances the high-temperature friction properties of Al-12Si. Therefore, this study provides a novel approach for the development of piston materials for biodiesel engines.
Nonlinear Analysis and Control with Nonlinear Driving Terms for Small-Emittance Storage Ring
Authors: Oh Bonghoon , Ko Jinjoo , Shin Seunghwan , Kim Jaehyun , Lee Jaeyu , Jang Gyeongsu 
Published: December 2023

Abstract

Storage rings that use the hybrid multi-bend achromat (MBA) lattice concept [1] have been realized. ESRF-EBS was the first hybrid MBA machine to be built and is now in operation. Main characteristics of hybrid MBA as a typical lattice for 4th generation storage ring are to adopt two large dispersion bumps in cell, and to make a -I-transformation between two dispersion bumps to cancel nonlinear effects. To increase the effectiveness of nonlinear control, analytical investigation of nonlinear phenomenon is essential. In this paper, we describe the result of analytical investigation with a nonlinear driving term and simple model. We obtained similar results to the existing time-consuming MOGA optimization using a simplex optimizer with a small number of nonlinear control knobs.
Derivation of two human induced pluripotent stem cell lines carrying a missense mutation in FHL1 (c.377G&gt;A, p.C126Y) linked to familial muscular dystrophy
Authors: Zabalegui Federico , Castañeda Sheila Lucia , Amin Guadalupe , Belli Carolina , Miriuka Santiago Gabriel , Moro Lucía Natalia 
Published: December 2023

Abstract
FHL1 gene locates in the Xq26 region and encodes for four and half LIM domain protein 1. It plays a crucial role in muscle cells and mutations in FHL1 are related to muscular dystrophy (MD). Peripheral blood mononuclear cells (PBMCs) were obtained from 2 family patients with MD that carry a pathogenic missense mutation in FHL1 (c.377G > A, p.C126Y). Induced pluripotent stem cells (iPSCs) were generated by PBMCs reprogramming using the lentiviral-hSTEMCCA-loxP vector, obtaining FHL1-T and FHL1-V iPSCs lines from patients. FHL1 genotype was maintained, and stemness and pluripotency were confirmed in both iPSCs lines.
Experimental and finite element study of the application of ferro cement composite on runway rigid pavement
Authors: samra Hassan Abdel elrahman Abo 
Published: December 2023

Abstract
Aircraft with different weights and gear configurations are landing on airport runways. It is clear that this difference in airplanes causes different quantities of damage to rigid and flexible pavements [1]. The main objective of this research is to study the impact resistance and energy absorption properties of reinforced ferrocement concrete slabs. Ferrocement is a composite material in which the inherent properties of two constituent materials are optimally utilized. The filler material is reinforced with layers of reinforcing mesh in both principal directions. However, the subdivision and distribution of ductile material (wire mesh) throughout the matrix increase its elasticity [2, 3, 4]. For this study, 18 different ferrocement slabs of dimensions 400mm X 400mm X 50mm and reinforced with 1Ø5.5 every 100 mm were casted with alteration in the combinations of mesh layers, and test results were analyzed. The impact load testing has been performed after the slabs have been heated in the oven for 24 hours at a temperature of 50°C and 100°C. The impact loading was applied to the specimens by dropping a 5-kg steel ball from a height of 1 m at the center of the slabs. The impact energy at the initial cracking stage and at failure was determined for all the slabs. Experimental results are then compared to analytical models using (ABAQUS) programs. The results indicated that higher energy absorption, maximum numbers of blows, and maximum displacement at the last blow are achieved in slabs of a combination of 2 layers of woven mesh and 4 layers of welded mesh at a temperature of 50°C as they are effective in controlling the developed cracks. It was observed that slabs of a combination of 2 layers of woven mesh and 4 layers of welded mesh at a temperature of 50°C had maximum numbers of blows, higher energy absorption, and maximum displacement at the last blow. In addition, a slab of a combination of 1 layer of welded mesh at a temperature of 100°C showed lower numbers of blows, energy absorption, and displacement.
Germination specifics and introduction into in vitro culture of Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk.
Authors: Elisafenko T V. , Zheleznichenko T. V. , Yugrina P. N. , Zhigmittsyrenova B. M. , Kazakov M. V. , Taraskin V. V. 
Published: December 2023

The article examines the effect of storage conditions, mericarp processing, and germination conditions of the endemic Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk. on germination. The technological process of obtaining aseptic in vitro culture was perfected. Mericarps collected from introduced species in 2022 were examined. Explants were sterilized once or twice with 0.1% AgNO3 or 0.1% AgNO3, followed by the use of 10% Н2О2. The pericarp was removed from the sterilized mericarps, and seeds were germinated on a solid 1/2 Murashige and Skoog medium. Callus genesis was induced by culturing the true leaves of seedlings on a Murashige and Skoog medium supplemented with 2,4-dichlorophenoxyacetic acid (10 μM) and 6-benzylaminopurine (0–5 μM) in the dark. The seeds of S. divaricata exhibit shallow dormancy, and the most favorable conditions for their germination are stratification for 30 days at 4 °С or the scarification of mericarps and germination in an environmental chamber (photoperiod of 16.5 h and a daytime temperature of 27 °С with its slight decrease at night). Laboratory germination capacity reaches 94%. The absence of whole seeds at the end of the experiment suggests a small soil seed bank, which accounts for the vulnerability of natural populations along with monocarpy. The in vitro culture of S. divaricata was obtained. Pericarp removal from mericarps was shown to accelerate germination and improve germination capacity while significantly reducing contamination. A callus was formed on leaf petioles in 66% of explants on an auxin medium, while on a medium with auxin and cytokinin, it was formed across the entire surface of the leaf blade in 72% of explants. Further callus development occurred only on the auxin medium.
Biochemical composition of fruit must from small-fruit apple varieties grown in the Southern Baikal Region
Authors: Suprun N. P. , Gusakova G. S. , Anikina N. S. , Slastya E. A. 
Published: December 2023

Most climatic zones of the Russian Federation include vast apple plantations that serve as the primary source of raw materials for the production of cider and fruit alcoholic beverages. The technological potential of new apple varieties in the production of fruit alcoholic beverages is understudied. The present study aims to examine the chemical composition (including the fractional composition of sugars and organic acids) of fruit must from small-fruit apple varieties grown in the Southern Baikal region and to identify the most suitable varieties for cider production.The biochemical composition of must was determined via conventional methods as per state standards. Smallfruit semi-cultivars grown in the Southern Baikal Region are characterized by variability in the content of extractive substances. In different years, the fruit of the same variety accumulates different amounts of dissolved solids (12.5–14.5%), primarily sugars (109.3–135.3 g/dm3). Among sugars, fructose is the most abundant (over 50%), followed by glucose. The proportion of disaccharides in the composition of sugars in the fruits of different varieties ranges from 9.1 to 21.5%. The concentration of organic acids in the studied varieties ranges from 7.2 to 13.0 g/dm3. The detected organic acids include malic acid (up to 83.4%), citric acid (up to 6.7%), lactic acid (up to 6.4%), succinic acid (up to 2.5%), as well as trace amounts of tartaric and acetic acids. The amount of phenolic compounds in the specimens varies from 522.5 to 1704.6 mg/dm3. The studied semi-cultivars were classified as sharp and bittersharp cider apple varieties.
STAFNE KEMİK KAVİTESİNİN PANORAMİK RADYOGRAFİ İLE DEĞERLENDİRİLMESİ : RETROSPEKTİF BİR ÇALIŞMA
Authors: YÜKSEL KAYA Ebru , GEDUK Gediz , ŞEKER Çiğdem 
Published: December 2023

Amaç: Stafne kemik kavitesi (SKK) terimi, çoğunlukla mandibular kemiği etkileyen lokalize bir kemik defektini tanımlar. Bu çalışmanın amacı, kliniğimize başvuran hastalarda SKK prevelansını belirlemek, SKK’nin panoramik radyografilerdeki özelliklerini tanımlamak ve olası karakteristik özelliklerini belirlemektir.
Gereç ve Yöntemler: Zonguldak Bülent Ecevit Üniversitesi’ne 2019-2022 yılları arasında çeşitli nedenlerle başvuran 17.258 hastanın panoramik radyografileri retrospektif olarak tarandı. Çalışmaya dahil edilen 16.115 panoramik radyografi içinden SKK tespit edilen hastaların yaşı, cinsiyeti kayıt altına alındı ve defektin bulunduğu taraf , defektin şekli, marjin sklerozu, internal radyolusensi derecesi, lokularitesi, mandibular kanalla olan ilişkisi, mandibula inferior korteksiyle ilişkisi değerlendirildi, yatay ve dikey boyut ölçümleri kaydedildi.
Bulgular: İncelenen 16.115 görüntü arasından 15’inde (% 0.09) SKK belirlendi. En fazla gördüğümüz radyografik özellikler; oval şekil (% 73.3), kalın sklerotik sınır (% 53.3), homojen olmayan radyolusent içerikti (% 53.3). Defektlerin sadece 1 tanesi multiloküleydi. Defektlerin mandibular kanalla olan ilişkisinde ise defektlerin çoğu mandibular kanalın alt duvarının altında bulunuyordu (% 53.3).
Sonuç: Bu çalışma, rutin diş hekimliği pratiğinde önemli radyografik incelemeler olan panoramik radyografilerde SKK’nın temel görüntüleme özelliklerini açıkladığı için önemlidir.
Anahtar Kelimeler: Mandibula, Panoramik Radyografi, Prevalans, Retrospektif çalışmalar