bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer‐associated non‐bacterial thrombotic endocarditis—Clinical series from a single institution
Authors: Patrzalek Patryk , Wysokinski Waldemar E. , Kurmann Reto D. , Houghton Damon , Hodge David , Kuczmik Wiktoria , Klarich Kyle W. , Wysokinska Ewa M. 
Published: February 2024

AbstractPremortem clinical presentation of cancer‐associated non‐bacterial thrombotic endocarditis (Ca‐NBTE), therapy, and the clinal course is limited to case reports and small clinical series. An electronic search of Mayo Clinic records (03/31/2002–06/30/2022) with a subsequent manual review was performed to identify adult patients with echocardiographically detected NBTE and active malignancy, excluding those with infectious endocarditis or lupus anticoagulant/antiphospholipid antibodies. In this retrospective cohort study, we analyzed 115 Ca‐NBTE patients (mean age 63.2 ± 9.7 years, 66.1% female) involving 71 (61.7%) mitral, 58 (50.4%) aortic, 8 (6.9%) tricuspid, and 1 (0.9%) pulmonary valve. The most common cancer was lung (n = 45 cases (39.1%), followed by pancreatic (n = 19, 16.5%), gynecological (17, 14.8%), gastrointestinal (n = 10, 8.7%), and 10 (8.7%) with hematologic malignancy; 6 patients had two active cancers. Embolic complications at presentation were frequent: 94 (81.7%) brain, 11 splenic, 10 renal, 6 coronary, and 4 to the extremities. Of 104 anticoagulated patients, 60 received low molecular weight heparin, 17 unfractionated heparin, 16 apixaban, 8 warfarin, and 3 rivaroxaban. There were 18 arterial thromboembolisms; the Kaplan–Meier estimates of the incidence at 2 years were consistent with a rate of 15.9% [95% Confidence Interval (CI) 9.9–23.3], including 14 strokes (12.4%, 95%CI, 7.1–19.2), and 8 other arterial emboli (10.5%, 95%CI, 4.7–18.9); there were 10 venous thromboembolisms (8.9%, 95%CI, 4.5–15.0). Fourteen major bleedings occurred (12.8%, 95%CI, 7.3–19.9) and 94 patients died during follow‐up (77.9%, 95%CI, 71.1–85.8). Ca‐NBTE predominantly affected women with lung adenocarcinoma or digestive tract cancers and manifested by stroke with high mortality and frequent embolic and bleeding complications during anticoagulation therapy.
Reversible Selbstassemblierung von Nukleinsäuren in einer diffusiophoretischen Falle
Authors: Katzmeier Florian , Simmel Friedrich C. 
Published: February 2024

AbstractDie Bildung und Dissoziation von Duplexen oder komplexeren Strukturen aus Nukleinsäuresträngen ist ein fundamentaler Prozess mit vielfältigen Anwendungen in Biochemie und Nanotechnologie. Hier führen wir ein einfaches experimentelles System – eine diffusiophoretische Falle – für die Nichtgleichgewichts‐Selbstassemblierung von Nukleinsäurestrukturen ein, das einen Elektrolytgradienten als Antrieb nutzt. DNA‐Stränge können durch Diffusiophorese im elektrischen Feld eines Elektrolytgradienten bis zu hundertfach konzentriert werden. Geeignete Elektrolyte für diese diffusiophoretische Falle können mit Hilfe einer einfachen Gleichung bestimmt werden. Experimente mit carboxylierten Siliziumdioxidpartikeln zeigen, dass die diffusiophoretische Kraft langreichweitig und über hunderte von Mikrometern wirksam ist. Als Anwendung untersuchen wir die reversible Selbstassemblierung verzweigter DNA‐Nanostrukturen in der Falle zu einem makroskopischen Gel. Die Strukturen assemblieren in Anwesenheit eines Elektrolytgradienten und lösen sich bei dessen Entfernung wieder auf, was eine prototypische adaptive Reaktion auf einen makroskopischen Nichtgleichgewichtszustand darstellt.DiffusiophoreseDNA‐NanosterneSelbstorganisationDNA‐StrukturenNichtgleichgewichtsprozesse
Deoxygenative Coupling of CO with a Tetrametallic Magnesium Hydride Complex
Authors: Yang Wenbang , White Andrew J. P. , Crimmin Mark R. 
Published: February 2024

AbstractAddition of CO to a tetrametallic magnesium hydride cluster results in both carbon‐carbon bond formation and deoxygenation to generate an acetaldehyde enolate [C2OH3]− which remains coordinated to the cluster. To the best of our knowledge, this is the first example of formation of an isolable complex containing an [C2OH3]− fragment from reaction of CO with a metal hydride, and the first example of CO homologation and deoxygenation at a main group metal. DFT studies suggest that key steps in the mechanism involve nucleophilic attack of an oxymethylene on a formyl ligand to generate an unstable [C2O2H3]3− fragment, which undergoes subsequent deoxygenation.
Multisite Fine‐Tuning in Hybrid Cadmium Halides Enables Wide Range Emissions for Anti‐Counterfeiting
Authors: Zhang Zhizhuan , Jin Jiance , Lin Yangpeng , Xu Haiping , Cheng Juan , Zeng Hongmei , Lin Zhien , Xia Zhiguo , Zou Guohong 
Published: February 2024

AbstractAchieving tunable emissions spanning the spectrum, from blue to near‐infrared (NIR) light, within a single component is a formidable challenge with significant implication, particularly in tailoring multicolor luminescence for anti‐counterfeiting purposes. In this study, we demonstrate a broad spectrum of emissions, covering blue to red and extending into NIR light in [BPy]2CdX4 : xSb3+ (BPy=Butylpyridinium; X=Cl, Br; x=0 to 0.08) through precise multisite structural fine‐tuning. Notably, the multicolor emissions from [BPy]2CdBr4 : Sb3+ manifest a distinctive pattern, transitioning from blue to yellow in tandem with the host [BPy]2CdBr4 and further extending from yellow to NIR with its homologous [BPy]2CdCl4 : Sb3+, resulting in the simultaneous presence of intersecting and independent emission colors. Detailed modulation of chemical composition enables partial luminescence switching, facilitating the creation of diverse patterns with multicolor luminescence by employing [BPy]2CdX4 : xSb3+ as phosphors. This study for the first time successfully implements several groups of tunable emission colors in a single matrix via multisite fine‐tuning. Such an effective strategy not only develops the specific relationships between tunable emissions and adjustable compositions, but also introduces a cost‐effective and straightforward approach to achieving unique, high‐level, plentiful‐color and multiple‐information‐storage labels for advanced anti‐counterfeiting applications.
Optical Sensor Arrays for the Detection of Neurotransmitters
Authors: Jana Palash , Bandyopadhyay Subhajit 
Published: February 2024

AbstractNeurotransmitters are essential for electrochemical communication between neurons. Accurate detection and monitoring of neurotransmitters are crucial for comprehending the intricacies of the human nervous system. Despite their crucial role, neurotransmitters exist in the human body at low concentrations amidst other cellular components, posing challenges for their precise detection and quantification. While electrochemical detection stands as an important technique, its point‐of‐care diagnostic applications are constrained by complex machinery and sample preparation. To address this limitation, alternative detection strategies for neurotransmitters have been explored. This review discusses the development and principles of array‐based sensors designed for facile and rapid detection of neurotransmitters. Moreover, it explores future prospects for the implementation and advancement of these techniques, envisioning a promising trajectory for improved understanding and manipulation of the human nervous system.
Late Holocene hunting economies in coastal southeastern Australia: Insights from the archaeological fauna of Curracurrang 1 Rockshelter, Royal National Park
Authors: Koungoulos Loukas G. , Balme Jane , O'Connor Sue , Ingrey Shane 
Published: February 2024

ABSTRACTCurracurrang 1 (1CU5) is a rockshelter site located in the Royal National Park (RNP) on the coast south of Sydney. Excavated from 1962 to 1966, the site's rich Holocene cultural deposit has become important for understanding regional Late Holocene developments in Australian lithic and shell technologies. Our comprehensive analysis of 1CU5's faunal remains is presented here, accompanied by new AMS radiocarbon dates and a reinterpretation of the site's occupation sequence. Much of the midden deposit spans from about 2500 BP to approximately 1850 AD, rather than only the last ∼1500 years as originally believed based on less comprehensive dating. A wide range of terrestrial and marine fauna were exploited at 1CU5, with the relative importance of the latter group increasing within the last ∼1500 years. Greater fish consumption during the later period may relate to use of novel hook and line fishing technology using hooks made from shellfish, but concurrent increases in seals, seabirds and marine invertebrates suggest a broader increased reliance on marine resources. By comparison, the earlier period, which coincides with the manufacture of backed microliths, displays relatively greater reliance on terrestrial marsupials. Taxonomic representation suggests occupation of the shelter from winter through spring, and potentially into summer. Analysis of the 1CU5 fauna marks an important contribution to the understanding of Late Holocene economies at the interface of the greater Sydney and NSW South Coast cultural and biogeographic regions.
Selenium mitigates methotrexate‐induced testicular injury: Insights from male NMRI mice model
Authors: Gholami Mohammadreza , Nemati Afsaneh , Zarasvand Azita Alasvand , Zendehdel Abolfazl , Jalili Cyrus , Rashidi Iraj , Mansouri Kamran , Taheri Forough , Assadollahi Vahideh , Gholami Elham 
Published: February 2024

AbstractBackground and AimChemotherapy, particularly with methotrexate (MTX), often elicits testicular toxicity, leading to impaired spermatogenesis and hormone imbalances. This study aimed to investigate the potential protective effects of selenium (Se) against MTX‐induced testicular injury.Materials and MethodsMale mice were divided into control, MTX, Se, and MTX + Se groups. Histopathological examination involved the preparation of testicular tissue sections using the Johnsen's tubular biopsy score (JTBS) for spermatogenesis evaluation. Biochemical tests included the assessment of testosterone, malondialdehyde (MDA), luteinizing hormone (LH), and follicle‐stimulating hormone (FSH) levels. Real‐time quantitative polymerase chain reaction (RT‐qPCR) was employed to analyze the expression of caspase 3 (casp3), tumor protein 53 (p53), B‐cell lymphoma 2 (Bcl2), and Bcl2‐associated X protein (Bax) genes. Statistical analysis was performed using ANOVA and Tukey's tests (p < .05).ResultsHistopathological analysis revealed significant testicular damage in the MTX group, with decreased spermatogenesis and Leydig cell count, while Se administration mitigated these effects, preserving the structural integrity of the reproductive epithelium. Biochemical analysis demonstrated that MTX led to elevated malondialdehyde (MDA) levels and reduced testosterone, LH, and FSH levels, suggesting oxidative stress and Leydig cell dysfunction. Gene expression analysis indicated that MTX upregulated proapoptotic genes (casp3, p53, and bax) while downregulating the antiapoptotic Bcl2 gene. In contrast, Se treatment reversed these trends, highlighting its potential antiapoptotic properties.ConclusionOur findings underscore the potential of Se as a therapeutic agent to mitigate the reproductive toxicity associated with MTX‐induced testicular injury. Se exerts protective effects by regulating oxidative stress, preserving hormone balance, and modulating apoptotic pathways. These results suggest that Se supplementation could be a promising strategy to alleviate chemotherapy‐induced testicular damage and preserve male fertility.
How to improve IARC's RF‐EMF cancer hazard communication
Authors: Wiedemann Peter M. , Croft Rodney J. 
Published: February 2024

AbstractA crucial aspect of IARC's evaluation of the relative carcinogenicity of agents is the communication of its conclusions. The present paper addressed the experimental risk perception literature pertaining to IARC's radiofrequency electromagnetic field evaluation communication, and derived specific recommendations for improving it.
Plasma SOMAmer proteomics of postoperative delirium
Authors: Leung Jacqueline M. , Rojas Julio C. , Sands Laura P. , Chan Brandon , Rajbanshi Binita , Du Zhiyuan , Du Pang ,   the Perioperative Medicine Research group
Published: February 2024

AbstractBackgroundPostoperative delirium is prevalent in older adults and has been shown to increase the risk of long‐term cognitive decline. Plasma biomarkers to identify the risk for postoperative delirium and the risk of Alzheimer's disease and related dementias are needed.MethodsThis biomarker discovery case–control study aimed to identify plasma biomarkers associated with postoperative delirium. Patients aged ≥65 years undergoing major elective noncardiac surgery were recruited. The preoperative plasma proteome was interrogated with SOMAmer‐based technology targeting 1433 biomarkers.ResultsIn 40 patients (20 with vs. 20 without postoperative delirium), a preoperative panel of 12 biomarkers discriminated patients with postoperative delirium with an accuracy of 97.5%. The final model of five biomarkers delivered a leave‐one‐out cross‐validation accuracy of 80%. Represented biological pathways included lysosomal and immune response functions.ConclusionIn older patients who have undergone major surgery, plasma SOMAmer proteomics may provide a relatively non‐invasive benchmark to identify biomarkers associated with postoperative delirium.
Racial disparities in the relationship of regional socioeconomic status and colorectal cancer survival in the five regions of Georgia
Authors: Tsai Meng‐Han , Vernon Marlo , Su Shaoyong , Coughlin Steven S. , Dong Yanbin 
Published: February 2024

AbstractIntroductionThe study's purpose was to examine 5‐year colorectal cancer (CRC) survival rates between White and Black patients. We also determined whether regional socioeconomic status (SES) is associated with CRC survival between White and Black patients in the Clayton, West Central, East Central, Southeast, and Northeast Georgia public health districts.MethodsWe performed a retrospective cohort analysis using data from the 1975 to 2016 Surveillance, Epidemiology, and End Results program. The 2015 United States Department of Agriculture Economic Research Services county typology codes were used to identify region‐level SES with persistent poverty, low employment, and low education. Kaplan–Meier method and Cox proportional hazard regression were performed.ResultsAmong 10,876 CRC patients (31.1% Black patients), 5‐year CRC survival rates were lower among Black patients compared to White patients (65.4% vs. 69.9%; p < 0.001). In multivariable analysis, White patients living in regions with persistent poverty had a 1.1‐fold increased risk of CRC death (HR, 1.12; 95% CI, 1.00–1.25) compared to those living in non‐persistent poverty regions. Among Black patients, those living in regions with low education were at a 1.2‐fold increased risk of CRC death (HR, 1.19; 95% CI, 1.01–1.40) compared to those living in non‐low education regions.Discussion and ConclusionsBlack patients demonstrated lower CRC survival rates in Georgia compared to their White counterparts. White patients living in regions with persistent poverty, and Black patients living in regions with low education had an increased risk of CRC death. Our findings provide important evidence to all relevant stakeholders in allocating health resources aimed at CRC early detection and prevention and timely referral for CRC treatment by considering the patient's regional SES in Georgia.
3D versus 2D: Effects of the number of dimensions of product images on perceptions of product size
Authors: Kwon Soonho , Suda Takanori , Nomura Takuya 
Published: February 2024

AbstractWhen shopping online, it is difficult to estimate size from visual cues in the form of product images. While package shape and color have been discussed as factors influencing perceptions of product size, this research focuses on the influence of visual cues, such as the number of dimensions of the product image (i.e., two‐dimensional image vs. three‐dimensional image) on perceptions of product size. This study involved three surveys whose results revealed that three‐dimensional product images are perceived as larger products than two‐dimensional product images. Moreover, three‐dimensional product images positively influenced perceived product weight, suggesting a downstream effect from perceived weight on willingness to pay (WTP, Study 3). The results of this study contribute to a better understanding of how consumers perceive product size from product images in online retailing. Specifically, the results of this study extend our understanding of the mechanisms behind product size perception by including the influential factor of product image dimensionality in size perception bias. In addition, these findings have practical implications. In recent years, food packaging has become smaller, but consumers may react negatively to smaller packages, even when the volume of the contents remains unchanged. For these practical concerns, it may be possible to mitigate the negative effects of downsizing by presenting product images in a three‐dimensional format.
Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications
Authors: Allani Meghana , Akhilesh  , Tiwari Vinod 
Published: February 2024

AbstractApoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed cell death, which plays an important role in cancer as a classical mechanism of tumor cell death causing minimal inflammation without causing damage to other cells in the vicinity. Induction of apoptosis by activation of caspases is one of the primary targets for cancer treatment. Over the years, a diverse range of natural, synthetic, and semisynthetic compounds and their derivatives have been investigated for their caspase‐mediated apoptosis‐induced anticancer activities. The review aims to compile the preclinical evidence and highlight the critical mechanistic pathways related to caspase‐induced cell apoptosis in cancer treatment. The focus is placed on the key components of the mechanisms, including their chemical nature, and specific attention is given to phytochemicals derived from natural sources and synthetic and semisynthetic compounds. 180+ compounds from the past two decades with potential as anticancer agents are discussed in this review article. By summarizing the current knowledge and advancements in this field, this review provides a comprehensive overview of potential therapeutic strategies targeting apoptosis in cancer cells. The findings presented herein contribute to the ongoing efforts to combat cancer and stimulate further research into the development of effective and targeted anticancer therapies.
The effect of photobiomodulation therapy in common maxillofacial injuries: Current status
Authors: Alam Mostafa , Karami Shahryar , Mohammadikhah Meysam , Badkoobeh Ashkan , Golkar Mohsen , Abbasi Kamyar , Soufdoost Reza Sayyad , Hakim Lotfollah Kamali , Talebi Sahar , Namanloo Reza Abdollahi , Hussain Ahmed , Heboyan Artak , Tebyaniyan Hamid 
Published: February 2024

AbstractThe use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering and regenerative medicine. Some studies suggest that PBMT may offer a promising therapy for traumatic maxillofacial injuries because it can stimulate the differentiation and proliferation of various cells, including dental pulp cells and mesenchymal stem cells, enhancing bone regeneration and osseointegration. PBMT reduces pain and swelling after oral surgery and tooth extraction in human and animal models of maxillofacial injuries. Patients with temporomandibular disorders also benefit from PBMT in terms of reduced inflammation and symptoms. PBMT still has some limitations, such as the need for standardizing parameters. PBMT must also be evaluated further in randomized controlled trials in various maxillofacial injuries. As a result, PBMT offers a safe and noninvasive treatment option for patients suffering from traumatic maxillofacial injuries. PBMT still requires further research to establish its efficacy in clinical practice and determine the optimal parameters.
Human 2′‐Deoxynucleoside 5′‐Phosphate N‐Hydrolase 1: The Catalytic Roles of Tyr24 and Asp80
Authors: Carberry Anna E. , Devi Suneeta , Harrison David J. , da Silva Rafael G. 
Published: February 2024

AbstractThe human enzyme 2′‐deoxynucleoside 5′‐phosphate N‐hydrolase 1 (HsDNPH1) catalyses the hydrolysis of 5‐hydroxymethyl‐2′‐deoxyuridine 5′‐phosphate to generate 5‐hydroxymethyluracil and 2‐deoxyribose‐5‐phosphate via a covalent 5‐phospho‐2‐deoxyribosylated enzyme intermediate. HsDNPH1 is a promising target for inhibitor development towards anticancer drugs. Here, site‐directed mutagenesis of conserved active‐site residues, followed by HPLC analysis of the reaction and steady‐state kinetics are employed to reveal the importance of each of these residues in catalysis, and the reaction pH‐dependence is perturbed by each mutation. Solvent deuterium isotope effects indicate no rate‐limiting proton transfers. Crystal structures of D80N‐HsDNPH1 in unliganded and substrate‐bound states, and of unliganded D80A‐ and Y24F‐HsDNPH1 offer atomic level insights into substrate binding and catalysis. The results reveal a network of hydrogen bonds involving the substrate and the E104‐Y24‐D80 catalytic triad and are consistent with a proposed mechanism whereby D80 is important for substrate positioning, for helping modulate E104 nucleophilicity, and as the general acid in the first half‐reaction. Y24 positions E104 for catalysis and prevents a catalytically disruptive close contact between E104 and D80.
Psychosis secondary to COVID‐19 in pediatric sickle cell disease
Authors: Khanchandani Ashish , Onuoha Chinonso , Fuh Beng 
Published: February 2024

Key Clinical MessageCOVID‐19 psychosis is a potential long‐term sequela of COVID‐19. Vulnerable populations, such as individuals with sickle cell disease, are at high risk for psychosis. Given the limited number of cases, more investigations in the etiopathology and management of this new disease is needed.AbstractWe report a case of a 15‐year‐old female with a past medical history of depression who developed psychosis post‐SARS‐CoV‐2 infection (COVID‐19). After an initial moderate COVID‐19 infection, the patient appeared to recover and was discharged home. Four weeks later, she presented with symptoms of psychosis and symptoms of cognitive impairment. Imaging studies did not show any evidence of stroke and toxicology studies were negative. She was treated with antipsychotics and required inpatient neuropsychiatric rehabilitation. Acute psychotic syndrome resolved after 3 weeks, antipsychotics were weaned, and an antidepressant was initiated. Mild cognitive impairment with significant memory loss persisted for about 1 year. Thereafter, she returned to her baseline but remains on an antidepressant. Some studies have previously reported the occurrence of psychosis in individuals with COVID‐19. This report is the first outline of severe prolonged post‐COVID‐19 psychosis in a child with sickle cell disease. Given the neurologic vulnerability of children with sickle cell disease, these individuals should be monitored for neuropsychiatric symptoms post COVID‐19.