bluuebunny/crossref_metadata_2025_split huggingface dataset:
Provision of Radiology Reports Simplified With Large Language Models to Patients With Cancer: Impact on Patient Satisfaction
Authors: Gupta Amit , Singh Swarndeep , Malhotra Hema , Pruthi Himanshu , Sharma Aparna , Garg Amit K. , Yadav Mukesh , Kandasamy Devasenathipathy , Batra Atul , Rangarajan Krithika 
Published: January 2025

PURPOSE
To explore the perceived utility and effect of simplified radiology reports on oncology patients' knowledge and feasibility of large language models (LLMs) to generate such reports.

MATERIALS AND METHODS
This study was approved by the Institute Ethics Committee. In phase I, five state-of-the-art LLMs (Generative Pre-Trained Transformer-4o [GPT-4o], Google Gemini, Claude Opus, Llama-3.1-8B, and Phi-3.5-mini) were tested to simplify 50 oncology computed tomography (CT) report impressions using five distinct prompts with each LLM. The outputs were evaluated quantitatively using readability indices. Five LLM-prompt combinations with best average readability scores were also assessed qualitatively, and the best LLM-prompt combination was selected. In phase II, 100 consecutive oncology patients were randomly assigned into two groups: original report (received original report impression) and simplified report (received LLM-generated simplified versions of their CT report impressions under the supervision of a radiologist). A questionnaire assessed the impact of these reports on patients' knowledge and perceived utility.

RESULTS

In phase I, Claude Opus-Prompt 3 (explain to a 15-year-old) performed slightly better than other LLMs, although scores for GPT-4o, Gemini, Claude Opus, and Llama-3.1 were not significantly different (
P
> .0033 on Wilcoxon signed-rank test with Bonferroni correction). In phase II, simplified report group patients demonstrated significantly better knowledge of primary site and extent of their disease as well as showed significantly higher confidence and understanding of the report (
P
< .05 for all). Only three (of 50) simplified reports required corrections by the radiologist.

CONCLUSION
Simplified radiology reports significantly enhanced patients’ understanding and confidence in comprehending their medical condition. LLMs performed very well at this simplification task; therefore, they can be potentially used for this purpose, although there remains a need for human oversight.
Regional Anesthesia and Pain Outcomes After Anterior Cruciate Ligament Reconstruction Surgery in Pediatric Patients: Society of Pediatric Anesthesia Improvement Network
Authors: Sadacharam Kesavan , Mandler Tessa , Staffa Steven J. , Pestieau Sophie R. , Fuller Clinton , Ellington Matthew , Sparks J. William , Fernandez Allison M. ,   SPAIN-ACL Investigators
Published: January 2025

BACKGROUND:
Optimal perioperative pain management is unknown for adolescent patients undergoing anterior cruciate ligament reconstruction (ACLR). The study aimed to determine the association of nerve blocks with short- and long-term pain outcomes and factors influencing self-reported neurological symptoms.

METHODS:
We performed a multisite, prospective observational study of adolescent patients undergoing ACLR. Perioperative data included demographics, block details, anesthetic, and surgical techniques. Self-reported surveys documented pain scores, medication use, and neurological symptoms at various time points after the surgery (postoperative day [POD] 1, POD 3, week 6, and month 6). Associations between different groups of peripheral nerve blocks (PNBs) and the absence of a block were analyzed for their effects on acute postoperative pain outcomes. In addition, factors influencing self-reported neurological outcomes were determined using both univariate and multivariate regression.

RESULTS:
Data from 519 subjects (aged 15 years, 55.7% female) showed that 23.9% of patients with anterior plus posterior nerve blocks (A+P PNB) reported severe postanesthesia care unit (PACU) pain scores, compared to 40% with no PNB and 38.3% with anterior PNB (A-PNB). Patients receiving A-PNB or A+P PNB had significantly lower intraoperative morphine equivalents (MEs) (0.49 mg/kg and 0.46 mg/kg, respectively) vs no block patients (0.61 mg/kg). Total PACU MEs were lower for any patient who received a PNB. Multivariable logistic regression analysis showed that patients who received A+P PNB or a hamstring autograft had lower POD 1 severe pain scores (odds ratio [OR] = 0.35; 95% confidence interval [CI], 0.15–0.84 and OR = 0.35; 95% CI, 0.15–0.83, respectively). Patients with PNBs with local anesthesia concentration (LAC) greater than 0.25% reported higher POD1 pain scores (OR = 2.14; 95% CI, 1.1–4.16) compared to those with lower LAC. Patients with PNB catheters had reduced POD 1 pain. Multivariable logistic regression analysis for numbness at week 6 revealed a greater odds of numbness for A-PNB with LAC >0.25% (OR = 5.13; 95% CI, 1.27–20.8). At month 6, patients receiving PNB with perineural steroid adjuvant were more likely to report numbness (dexamethasone OR = 5.93; 95% CI, 1.61–21.9, methylprednisolone OR = 11.3; 95% CI, 2.16–58.6).

CONCLUSIONS:
Patients who received A+P PNB had lower postoperative pain scores than those who received no block. Additional studies are necessary to discern how PNB type, graft harvest site, LAC, and adjuvants influence pain control, persistent numbness, and weakness.
Behavioural patterns of university students during the COVID-19 pandemic: A cross-sectional study of the effects of active transportation, uninterrupted sitting time, and screen use on physical activity and sitting time
Authors: Marchant Gonzalo , Chevance Guillaume , Ladino Andrés , Lefèvre Brice , Jacquemond Nicolas 
Published: January 2025

Background The closure of universities due to the coronavirus disease 2019 (COVID-19) pandemic significantly affected students’ behaviours, particularly regarding physical activity, sitting time, and screen use. This study aimed to determine the effect of active transportation duration, uninterrupted sitting time, and screen time to study on physical activity and sitting time during the confinement. Methods This was a cross-sectional study based on data collected via an online questionnaire for university students during the second confinement in France (between October and December 2020). The questionnaire assessed physical activity and sedentary behaviour, and contained questions about modes of transport, and perception of uninterrupted sitting time and screen time to study prior to confinement and during confinement. Participants (N=2873) completed the International Physical Activity Questionnaire (IPAQ) in an average time of around 15 minutes, after providing digital informed consent. Multiple regression models assessed how time duration of active transportation, uninterrupted sitting time, and screen time studying increased or reduced confinement effects on physical activity and sitting time. Results The regression models showed that physical activity decreased during confinement for students who engaged in more prolonged periods of active transportation prior to confinement. Moreover, the perception of long, uninterrupted sitting time and high screen time prior to confinement significantly increased sitting time during confinement. Students who adopted the most active transport time prior to confinement were the least likely to increase their screen time during confinement. Conclusions Confinement reduced physical activity levels and increased sitting time, mainly among students who adopted active transport and accumulated longer uninterrupted sitting time prior to confinement. Students who combined-long periods of uninterrupted sitting time with high screen use could be a riskier profile for health. Analysis of physical activity time and sitting position should include its accumulation patterns.
Quilombos virtuais: as novas expressões de (re)territorialização, resistência, ativismo e empoderamento negro nas redes sociais.
Authors: Dos Santos Cristiano Henrique , Da Silva Renata Nascimento 
Published: January 2025

O presente artigo busca analisar os processos, fluxos e refluxos, de desterritorialização e territorialização, no contexto da diáspora negra no Brasil. Através dos conceitos de quilombismo e comunidade, examinará as comunidades virtuais “Ponte para Pretx” e “Intelectuais Negras: escrita de si mesma” localizadas no Facebook, articulando ponderações e reflexões em torno dos processos de empoderamento negro, ativismo, solidariedade e resistência negra, nucleados na ideia de comunidade virtual. Desta maneira, através dos pressupostos da hermenêutica histórica, a pesquisa demonstrará de que maneira as comunidades virtuais fortalecem a cultura negra, segundo a potência de construir territórios de sentido às populações negras brasileiras em torno de arranjos e organizações sociais e culturais.
Nondestructive Assessment of Hardwood Cross-Laminated Timber
Authors: Omotayo Richard , França Frederico J. N. , França Tamara S. F. A. , Seale R. Daniel 
Published: January 2025

Abstract
This study investigated the use of longitudinal vibration technique to evaluate the mechanical properties of cross-laminated timber (CLT) of four species of lumber—red oak (Quercus rubra), sweetgum (Liquidambar spp.), yellow poplar (Liriodendron spp.), and southern pine (SYP; Pinus spp.). The hardwood CLTs for this study were made from low-grade lumber; SYP CLT was industrially manufactured. The dynamic modulus of elasticity (dMOE) was assessed using the Fakopp device. After nondestructive testing (NDT) evaluation, samples were then destructively tested and correlations between various properties were developed. These properties included bending modulus of elasticity (MOE), modulus of rupture (MOR), density, and dMOE. There was moderate correlation between MOE and dMOE for three of the species tested—red oak, sweet gum, and SYP; however, a weaker relationship was observed between MOR and dMOE for all species tested. The coefficient of correlation for MOE against density showed that 30 to 64 percent of tested samples fit into the linear relationship. The coefficient of correlation result suggests that NDT could be reliable for predicting the bending MOE of CLT. The NDT result for hardwood samples also showed that CLT from low-value hardwood lumber could be used for construction purposes, with 95 of 96 hardwood samples exceeding 8,300 MPa, the minimum allowable strength value specified in American National Standards Institute/The Engineered Wood Association for softwood CLT. This research shows that NDT techniques can be used for estimation of mechanical properties of hardwood CLT and are able to improve the grading of mass timber products.
The quality of life and well-being of nursing home residents and their relatives during the COVID-19 pandemic: A quantitative approach
Authors: Schneider Philippe , Abt Maryline , Cohen Christine , Marmier Nadine , Carvalho Lucia Ribeiro , Bucher Claudia Ortoleva 
Published: January 2025

Background
During the COVID-19 pandemic, nursing homes implemented protection measures to limit contact with others. Measures implemented in Switzerland included in-room isolation, prohibitions on group eating, and limitations on visiting and group activities. Nursing home residents thus experienced long periods of social isolation, which could have impacted their well-being and that of their relatives (whether direct family or other loved ones). The present study aimed to quantitatively describe and compare the quality of life, well-being and coping strategies of nursing home residents and their relatives during the implementation of protection measures against COVID-19 in the French-speaking part of Switzerland.

Method
136 residents and 47 relatives from 13 nursing homes responded to the Perceived Stress Scale (PSS), the Brief Coping Orientation to Problems Experienced (Brief-COPE) questionnaire, the Impact of Event Scale-6 (IES-6) and the Post-Trauma Growth Inventory (PTGI). The only (minimal) difference between groups was that resident’s QoL was evaluated using the WHOQOL-OLD, and relatives’ QoL was evaluated using the WHOQOL-BREF scale. Non-parametric T-test were used to compare between group when possible, and linear regression to evaluate predictor of quality of life.

Results
Results showed that relatives coped better with lockdown isolation than did residents, residents developed lower levels of post-traumatic stress symptoms than relatives but there was no difference between the groups regarding perceived stress. Multiple linear regression calculations on indicators of quality of life showed that overall quality of life was most impacted by perceived stress. In the Psychological Health subscale, the familial link also reached significance: relatives who were part of a resident’s direct family had a better psychological QoL than other loved ones from outside.

Conclusion
The protection measures against COVID-19 isolated nursing residents, which impacted their quality of life and distanced residents and their relatives. In both populations, stress symptoms were the single most important predictor of quality of life.
Relationships between multivitamins, blood biochemistry markers, and BMC and BMD based on RF: A cross-sectional and population-based study of NHANES, 2017–2018
Authors: Xu Lijuan , Wu Mengqi , Zhang Ying , Kun Hongsheng , Xu Jiangbao 
Published: January 2025

Background
Previous studies have separately suggested a possible association between the vitamin exposure, blood biochemical indicators, and bone density. Our study aimed to investigate the relationship between vitamin exposure serum concentrations, blood biochemical indicator serum concentrations, and BMC and BMD using the NHANES 2017–2018 nutrient survey data. This population-based cross-sectional study aimed to explore these associations.

Methods
In this study, we measured vitamin serum concentrations, serum ion serum concentrations, and serum biochemical indicators in adults participating in the NHANES. Skeletal status was assessed by evaluating BMC and BMD in the whole body. Given the inclusion of multiple variables and diverse data types, we used the RF to fit a multivariable model to estimate the associations between vitamin serum concentrations, blood biochemical indicator serum concentrations, and skeletal status.

Results
Under the dimension reduction and comparison selection of RF model, we identified ALP, CPK, and creatinine serum concentrations as the most important factors associated with BMC and BMD in multiple skeletal sites, and the gender, age, height, weight, and body mass index which were found to be related to BMC and BMD in different skeletal sites. Vitamin D and blood calcium serum concentrations were not the important factors associated with BMC and BMD and the three blood biochemical indexes were more important than the vitamin level for BMC and BMD.

Conclusion
The effect of vitamin serum concentrations and blood calcium serum concentrations on human bone density was not significant. ALP, CPK and creatinine serum concentrations body development indicators were identified as the most important factors related to bone status. The RF model can be used to comprehensively evaluate the effects of vitamin content and blood biochemistry serum concentrations in adults on BMC and BMD.
Cost-effectiveness analysis for implementation of smoking cessation strategies at primary health care settings in Tamil Nadu
Authors: Mahalingam Vasantha , Santhanakrishnan Ramesh Kumar , Malaisamy Muniyandi , Chelvanayagam Karthick , Mathiyazhagan Kavi , Bhaskar Adhin , Nagarajan Karikalan , Maria Selvam Jerard , Veeraiah Surendran , Rajsekar Kavitha , Tyagi Kirti , Chinnaiyan Ponnuraja 
Published: January 2025

Background
Smoking is a major public health concern in Tamil Nadu, as it is in many parts of the world. It is a leading cause of preventable diseases and deaths, with a significant economic burden on healthcare systems and society as a whole. Recognizing the need to address this issue, the implementation of smoking cessation strategies at primary health care (PHC) settings has gained attention. Conducting a cost-effectiveness analysis in this context can help policymakers and healthcare providers make informed decisions about the allocation of resources for such interventions.

Objectives
To compare the cost-effectiveness of the smoking cessation of proposed strategies (PSs), PS1: enhanced counselling (EC) + nicotine replacement therapy (NRT) + bupropion tablet; PS2: behavioural intervention (BI) + NRT + promotion of bupropion sustained release (SR); PS3: EC + NRT + promotion of bupropion SR with the current strategy (BI +NRT+ Bupropion) in a population of smokers aged ≥15 years attending the PHC in Tamil Nadu.

Methods
In this hypothetical cohort of 100,000 individuals using the decision tree analysis, a cost-effectiveness assessment was conducted for both proposed and existing strategies. The results were evaluated in terms of incremental cost-effectiveness ratios (ICERs) per person quitting smoking. To assess the robustness of the findings, one-way sensitivity analysis and probabilistic sensitivity analysis were performed which aims to explore and address the uncertainties associated with the outcomes.

Results
The cost of the current strategy (CS) was higher (₹359 or $4.28 million) when compared with PS1 (₹327 or $3.90 million) and PS3 (₹327 or $3.90 million) strategies. The PS2 with BI + bupropion SR + NRT was found to be more cost (₹2,720,571 or $ 32,414.76) as compared to current strategy. ICER values indicates that compared to the current strategy, the PS1 and PS3 were found to be cost-saving, whereas the PS2 was found to be cost-effective. The cost-effectiveness acceptability curve demonstrated that the PS1 and PS3 indicates 100% probability of the intervention being cost-saving. After excluding dominated interventions (PS2 and CS), the remaining strategies (PS1 and PS3) were compared. The PS3, with an incremental cost of ₹462,497 ($5,510) for 131 additional quitters, resulted in an ICER of ₹3,531 ($42) per quitter, making it a cost-effective option compared to PS1.

Conclusion
Our study findings indicate that the need for healthcare providers and policymakers to implement PS3 with EC, NRT, Bupropion SR, as which was found to be cost-saving compared to current practices.
Postanarchism and Critical Art Practices, Saul Newman and Tihomir Topuzovski (2024)
Authors: Vojnić Marko 
Published: January 2025

Review of: Postanarchism and Critical Art Practices, Saul Newman and Tihomir Topuzovski (2024)
London: Bloomsbury, 198 pp.,
ISBN 978-1-35041-034-3, h/bk, £85.00
Geschichte greifbar machen – 3D-Digitalisierungsprojekt am Landesarchiv Baden-Württemberg
Authors: Leiske Patrick 
Published: January 2025

Zusammenfassung
Anfang 2024 führte das Landesarchiv Baden-Württemberg als Pilotprojekt eine 3D-Digitalisierungsaktion durch, um von ausgewählten Archivobjekten virtuelle Zwillinge zu erstellen. Ziel des Projekts war neben dem Scannen der Objekte die Gewinnung von Erfahrung beim Erstellen und Archivieren von 3D-Dateien. Der Artikel geht auf die besonderen Anforderungen der 3D-Digitalisierung im Vergleich zur herkömmlichen 2D-Digitalisierung ein und beleuchtet die Möglichkeiten, die 3D-Technik in Zukunft bieten wird.
Von der Theorie zur Praxis – User Story Mapping in der Entwicklung von Onlineanwendungen für den Kulturbereich
Authors: Wachtel Ann-Christin , Rückert Susanne 
Published: January 2025

Zusammenfassung
Der Beitrag untersucht den Einsatz von User Story Mapping in der Entwicklung digitaler Projekte im Bibliotheksbetrieb, basierend auf einem Workshop der Thüringer Universitäts- und Landesbibliothek (ThULB). Die Methode, die Nutzer*innenbedürfnisse in den Fokus stellt, erleichtert die Priorisierung, fördert die Teamkommunikation und ermöglicht flexible Anpassungen. Der Workshop zeigte, dass User Story Mapping Projekte effizienter gestaltet und ein agiles Mindset etabliert. Potenziale bestehen besonders in der Ressourcenoptimierung und der nutzer*innenorientierten Weiterentwicklung digitaler Angebote.
Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics
Authors: Zhang Suping , Liu Yuqing , Dong Jin , Jiao Min , Gu Yongchun , Chen Liling , Yuan Na , Wang Jianrong , Yang Dezhao , Meng Fanwen 
Published: January 2025

Abstract
Dental pulp stem cells hold significant prospects for tooth regeneration and repair. However, a comprehensive understanding of the molecular differences between dental pulp stem cells (DPSC, from permanent teeth) and stem cells from human exfoliated deciduous teeth (SHED, from deciduous teeth) remains elusive, which is crucial for optimizing their therapeutic potential. To address this gap, we employed a novel data-independent acquisition (DIA) proteomics approach to compare the protein expression profiles of DPSC and SHED. Based on nano-LC-MS/MS DIA proteomics, we identified over 7,000 proteins in both cell types. By comparing their expression levels, 209 differentially expressed proteins were identified. Subsequent Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, along with protein–protein interaction network construction, revealed significant metabolic differences and key regulatory nodes. DPSC exhibited significantly higher expression of proteins belonging to the NDUFB family, SMARC family, RPTOR and TLR3. These proteins are known to be involved in critical cellular processes such as mitochondrial energy metabolism, mTOR-related autophagy pathway, and innate immune response. Conversely, SHED displayed elevated expression of AKR1B family, which participated in glycerolipid metabolism and adipogenic differentiation, PRKG1, MGLL and UQCRB proteins associated with thermogenesis. These findings highlight the specific proteomic landscape of DPSC and SHED, suggesting their distinct biological roles and potential applications.
Differentiating true precocious puberty and puberty variants in consecutive 275 girls: a single center experience
Authors: Sarıkaya Emre , Kilci Fatih 
Published: January 2025

Abstract

Objectives
This study aimed to identify clinical features of girls referred to a pediatric endocrinology clinic for suspected precocious puberty, differentiate true precocious puberty from other variants, evaluate treatment status, and identify distinguishing factors between patient groups.

Methods
We retrospectively evaluated the records of 275 consecutive girls aged 0–10 years referred for suspected precocious puberty.

Results
Among the patients, 30 (10.9 %) were diagnosed with precocious puberty, 35 (12.7 %) with premature adrenarche, 22 (8 %) with premature thelarche, 33 (12 %) with rapidly progressing early puberty, 108 (39.3 %) with early puberty, and 47 (17.1 %) had a normal diagnosis. Precocious puberty was associated with higher rates of overweight/obesity (p=0.002), advanced bone age (p<0.001), height SD, and mid-parental height SD difference (p<0.001), as well as a history of preterm birth (p=0.041). Patients with rapidly progressing early puberty had mothers with a lower age at menarche (p=0.040). No significant differences were found for being born small for gestational age, maternal polycystic ovary syndrome, screen time, and junk food consumption (p>0.05). Treatment was recommended for 32 patients (11.6 %), including 11 with precocious puberty and 21 with rapidly progressing early puberty.

Conclusions
Most patients referred for early pubertal development are diagnosed with normal puberty or its variants. Assessing preterm birth, early maternal menarche age, and advanced bone age helps identify true precocious puberty and rapidly progressing early puberty, aiding timely treatment.