bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneous bequests and social inequalities
Authors: Borissov Kirill , Bosi Stefano , Ha-Huy Thai , Pakhnin Mikhail 
Published: February 2025

Abstract
We study a growth model with two types of agents who are heterogeneous in their degree of family altruism. We prove that every equilibrium path of consumption, bequests, and capital converges to a unique steady state and study the effect of altruism on the properties of steady-state equilibrium. We show that aggregate income is positively related to both level of altruism and altruism heterogeneity. When altruism heterogeneity is low or moderate, income inequality follows an inverse U-shaped pattern relative to the level of altruism. These observations are consistent with the cross-country Kuznets curve linking different steady-state levels of income to steady-state levels of inequality. When altruism heterogeneity is high, income inequality decreases with the level of altruism. Our results suggest that heterogeneous altruism is a possible mechanism linking economic growth and income inequality.
Tunable attenuating diplexer using miniaturized multilayer graphene pads
Authors: Akkapanthula Sai Haranadh , Kagita Srujana 
Published: February 2025

Abstract
In this article, a coupled line diplexer (operating at 2.4 GHz and 3.5 GHz) which can be used as single-band filter with tunable attenuation characteristics in the pass band has been designed. Multilayer graphene (MLG) pads are used to achieve tunable features in this circuit. The graphene pads are placed at each branch of the diplexer. Single-band tunable attenuation characteristics are achieved by applying bias to graphene pads placed at optimum locations on the filter. The proposed tunable coupled line attenuating diplexer is realized on FR-4 glass epoxy substrate of thickness 1.58 mm with a total size of 45 × 75 mm2. By varying the bias voltage (0 V –6 V) of MLG pads the resistance of graphene pad placed in the circuit gets decreases thereby attenuating/controlling the transmission power to the other port in the required band. In lower pass band (2.28–2.55 GHz) the signal is attenuated from 3 to 10.8 dB and in higher pass band (3.2–3.58 GHz) signal is attenuated from 5 to 13 dB. Simulations of the structure with and without graphene pads have been carried out and are in good agreement with measured results.
Male Twin Live Births Following Unconditional Cash Transfers in Alaska: A Time-Series Analysis
Authors: Singh Parvati , Mark Nicholas , Cowan Sarah 
Published: February 2025

Abstract
Prior studies report a decline in male twin live births during economically stressful periods, presumably owing to higher selection in utero against frail male gestations, yet no study has examined the natural corollary: whether provision of economic support increases rates of male twin births. We examined whether male twin live births increase following income gains from the Alaska Permanent Fund Dividend (PFD)—the longest running unconditional cash transfer program in the US. We obtained the monthly volume of male (and female) twin and singleton live births, from January 1980 to December 2019, from Alaska’s Department of Health. Data on PFD timing and payment amounts came from Alaska’s Department of Revenue. We used time-series analyses to gauge whether the odds of male twin live births increase within 2−6 months following PFD receipt, controlling for autocorrelation. Results suggest that for every $1000 increase in PFD payments, the odds of male twin live births increase by 0.002 (p < .05) three months following PFD disbursement. This corresponds with 50 additional (individual) male twin live births statistically attributable to the cumulative PFD amount disbursed over our study period. Income gains through the PFD may correspond with reduced male-specific selection in utero in Alaska.
An interactive soft robotic hand-task training system with wireless task boards and daily objects on post-stroke rehabilitation
Authors: Shi Xiangqian , Yang Chengyu , Lee Pak Chung , Xie Disheng , Ye Zhongping , Li Zheng , Tong Raymond Kai-yu 
Published: February 2025

Abstract
We have developed an interactive system comprising a soft wearable robot hand and a wireless task board, facilitating the interaction between the hand and regular daily objects for task-oriented training in stroke rehabilitation. A ring-reinforced soft actuator (RSA) to accommodate different hand sizes and enable flexion and extension movements was introduced in this paper. Individually controlled finger actuators assist stroke patients during various grasping tasks. A wireless task board was developed to support the training, allowing for the placement of training objects and seamless interaction with the soft robotic hand. Evaluation with seven stroke subjects shows significant improvements in upper limb functions (FMA), hand-motor abilities (ARAT, BBT), and maximum grip strengths after 20 sessions of this task-oriented training. These improvements were observed to persist for at least 3 months post-training. The results demonstrate its potential to enhance stroke rehabilitation and promote hand-motor recovery. This lightweight, user-friendly interactive system facilitates frequent hand practice and easily integrates into regular rehabilitation therapy routines.
Radially Anisotropic 3D Velocity Model of the Central Apennines Lithosphere: The CI23 $C{I}_{23}$ Model
Authors: Stallone Angela , Krischer Lion , Magnoni Federica , Casarotti Emanuele , Baccheschi Paola , Fichtner Andreas 
Published: February 2025

AbstractWe present the first application of Full‐Waveform Inversion (FWI) for a radially anisotropic 3D velocity model of the lithosphere beneath central Italy. The retrieved model constrains P‐wave (, ) and S‐wave velocities (, ) in the period range 8–50 s. model correlates well with regional lithological formations and highlights a negative radial anisotropy anomaly localized beneath the epicentral region of the 2016–2017 Amatrice‐Visso‐Norcia (AVN) seismic sequence. An opposite trend (positive radial anisotropy anomaly, i.e. ) is observed in the area affected by the 2009 L’Aquila (AQ) seismic sequence. We interpret the velocity anomalies in terms of local tectonic structures, particularly the Olevano‐Antrodoco‐Sibillini (OAS) thrust—Gran Sasso Thrust (GST) systems, while also considering possible evidence of overpressured fluids and fluid migration. Additionally, the observed anomalies may reflect transient velocity variations induced by the ANV and AQ seismic sequences.
Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases
Authors: Wen Pei , Sun Zhixin , Yang Dongming , Li Jie , Li Zhiping , Zhao Mengyang , Wang DongDong , Gou Fengting , Wang Jingjing , Dai Yuexin , Zhao Deming , Yang Lifeng 
Published: February 2025

Abstract
Prion diseases are a group of fatal neurodegenerative disorders characterized by the abnormal folding of cellular prion proteins into pathogenic forms. The development of these diseases is intricately linked to oxidative stress and mitochondrial dysfunction. Irisin, an endogenous myokine, has demonstrated considerable neuroprotective potential due to its antioxidative properties. However, the protective effects of irisin against prion diseases have yet to be clarified. Our findings indicate that treatment with exogenous irisin can mitigate the apoptosis induced by PrP106–126. Additionally, irisin significantly reduces oxidative stress and alleviates the mitochondrial dysfunction triggered by PrP106–126. Furthermore, irisin treatment targets uncoupling protein 2 (UCP2) and activates the AMPK-Nrf2 pathway, substantially improving oxidative stress and mitochondrial dysfunction in N2a cells induced by PrP106–126. These results suggest that irisin represents a novel and promising therapeutic approach for treating prion diseases.
LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress
Authors: Yi Ying , Wu Min-Yu , Chen Kai-Tian , Chen An-Hai , Li Lin-Qiu , Xiong Qin , Wang Xian-Ren , Lei Wen-Bin , Xiong Guan-Xia , Fang Shu-Bin 
Published: February 2025

Abstract
According to the World Health Organization, more than 12% of the world’s population suffers from noise-induced hearing loss (NIHL). Oxidative stress-mediated damage to the stria vascularis (SV) is one of the pathogenic mechanisms of NIHL. Recent studies indicate that glycolysis plays a critical role in endothelial cells (ECs)-related diseases. However, the specific role of glycolysis in dysfunction of SV-ECs remain largely unknown. In this study, we investigated the effects of glycolysis on SV-ECs in vitro and on the SV in vivo. Our previous research identified the glycolysis pathway as a potential mechanism underlying the SV-ECs injuries induced by oxidative stress. We further examined the expression levels of glycolytic genes in SV-ECs under H2O2 stimulation and in noise-exposed mice. We found that the gene and protein expression levels of glycolytic-related enzyme LDHA significantly decreased at early phase after oxidative stress injury both in vitro and in vivo, and exhibited anti-inflammatory effects on macrophages (Mφ). Moreover, we analyzed the differential secretomes of SV-ECs with and without inhibition of LDHA using LC-MS/MS technology, identifying CX3CL1 as a candidate mediator for cellular communication between SV-ECs and Mφ. We found that CX3CL1 secretion from SV-ECs was decreased following LDHA inhibition and exhibited anti-inflammatory effects on Mφ via the CX3CR1 pathway. Similarly, the pro-inflammatory effect of LDHA-overexpressing SV-ECs was attenuated following inhibition of CX3CL1. In conclusion, our study revealed that glycolysis-related LDHA was reduced in oxidative stress-induced SV-ECs, and that LDHA inhibition in SV-ECs elicited anti-inflammatory effects on Mφ, at least partially through the CX3CL1-CX3CR1 pathway. These findings suggest that LDHA represent a novel therapeutic strategy for the treatment of NIHL.
Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer
Authors: Duranti Claudia , Iorio Jessica , Manganelli Valeria , Bagni Giacomo , Colasurdo Rossella , Lottini Tiziano , Martinelli Michele , Capitani Chiara , Boso Giulia , D’Alessandro Franco Nicolas , Sorice Maurizio , Becchetti Andrea , Misasi Roberta , Garofalo Tina , Arcangeli Annarosa 
Published: February 2025

Abstract
Plasma membrane macromolecular complexes function as signaling hubs that regulate cell behavior, which is particularly relevant in cancer. Our study provides evidence that the complex formed by the hERG1 potassium channel and the β1 subunit of integrin receptors preferentially localizes in Lipid Rafts (LRs) in Pancreatic Ductal Adenocarcinoma (PDAC) cell lines and primary samples. The complex recruits the p85 subunit of phosphatidyl-inositol-3-kinase (PI3K), activating phosphoinositide metabolism and triggering an intracellular signaling pathway centered on Akt. This pathway ultimately affects cancer cell proliferation through cyclins and p21, and cell migration through the small GTPase Rac-1 and f-actin organization. The hERG1/β1 integrin complex in LRs can be dissociated and the downstream signaling pathway can be inhibited by either disrupting LRs through methyl-beta-cyclodextrin (MβCD) or inhibiting cholesterol synthesis by statins. Treatment with a single chain bispecific antibody—scDb-hERG1-β1—specifically targeting the complex significantly potentiates the effects of both MβCD and statins on intracellular signaling. Consequently, these treatments decrease PDAC cell proliferation and motility in vitro. From a pharmacological perspective, different statins produce anti-neoplastic effects in synergy with scDb-hERG1-β1. Such combination also enhances tumor sensitivity to chemotherapeutic drugs, such as gemcitabine and oxaliplatin. The efficacy of these combination treatments depends on the amount of the hERG1/β1 integrin complex present on the plasma membrane of cancer cells. Finally, the combined treatment with statins and scDb-hERG1-β1 significantly reduces tumor growth and improves survival in vivo, in a preclinical mouse model. These results suggest that the combination of scDb-hERG1-β1 and statins represent a potential novel strategy for treating PDAC patients.
Extensive off-fault damage around the 2023 Kahramanmaraş earthquake surface ruptures
Authors: Liu Jihong , Jónsson Sigurjón , Li Xing , Yao Wenqian , Klinger Yann 
Published: February 2025

Abstract
Quantifying coseismic fault offsets for surface ruptures of major earthquakes is important for earthquake cycle and slip-rate studies, and thus for earthquake hazard assessments. However, measurements of such offsets generally underestimate fault slip due to inelastic deformation and secondary fault offsets, i.e., off-fault damage. Here, we use satellite synthetic aperture radar images to quantify off-fault damage in the two 2023 Kahramanmaraş (Türkiye) magnitude 7.8 and 7.6 earthquakes. We first derive three-dimensional coseismic surface displacements and show that on average ~35% of the coseismic slip is accommodated by off-fault damage within 5–7 km of the coseismic surface ruptures. Fault sections exhibiting geometrical complexities (e.g., bends and step-overs) experienced a higher level of off-fault damage than simpler fault sections. Our results highlight the importance of extending off-fault damage assessments to several km away from fault ruptures and indicate that fault offset measurements may underestimate slip-rate estimations by as much as a third.
Left–right-alternating theta sweeps in entorhinal–hippocampal maps of space
Authors: Vollan Abraham Z. , Gardner Richard J. , Moser May-Britt , Moser Edvard I. 
Published: February 2025

Abstract
Place cells in the hippocampus and grid cells in the entorhinal cortex are elements of a neural map of self position1–5. For these cells to benefit navigation, their representation must be dynamically related to the surrounding locations2. A candidate mechanism for linking places along an animal’s path has been described for place cells, in which the sequence of spikes in each cycle of the hippocampal theta oscillation encodes a trajectory from the animal’s current location towards upcoming locations6–8. In mazes that bifurcate, such trajectories alternately traverse the two upcoming arms when the animal approaches the choice point9,10, raising the possibility that the trajectories express available forward paths encoded on previous trials10. However, to bridge the animal’s path with the wider environment, beyond places previously or subsequently visited, an experience-independent spatial sampling mechanism might be required. Here we show in freely moving rats that in individual theta cycles, ensembles of grid cells and place cells encode a position signal that sweeps linearly outwards from the animal’s location into the ambient environment, with sweep direction alternating stereotypically between left and right across successive theta cycles. These sweeps are accompanied by, and aligned with, a similarly alternating directional signal in a discrete population of parasubiculum cells that have putative connections to grid cells via conjunctive grid × direction cells. Sweeps extend into never-visited locations that are inaccessible to the animal. Sweeps persist during REM sleep. The sweep directions can be explained by an algorithm that maximizes the cumulative coverage of the surrounding manifold space. The sustained and unconditional expression of theta-patterned left–right-alternating sweeps in the entorhinal–hippocampal positioning system provides an efficient ‘look around’ mechanism for sampling locations beyond the travelled path.
Microtubule inhibition as a proposed mechanism for the anthelmintic effect of phytochemicals isolated from Cicerbita alpina
Authors: Horgan Mark James , Sigg Ines , Poulopoulou Ioanna , Rodriguez-Mejias Francisco J. , Albertini Eva , Fusani Pietro , Fischer Florian , Martinidou Eftychia , Schuster Daniela , Martens Stefan , Dürr Pidder Jansen , Gauly Matthias , Stuppner Hermann , Weiss Alexander , Temml Veronika , Siewert Bianka 
Published: February 2025

Abstract
The alpine plant Cicerbita alpina (L.) Wallr., when grown as a sprout, is known as a bitter-tasting culinary delicacy. Recently it has also been reported to have anthelmintic activity, prompting further investigation into its mechanism of action. Liquid–liquid fractions were prepared from a methanolic extract of the aerial parts and were submitted in parallel to embryo development (ED), worm motility (WMT), and cytotoxicity assays for anthelmintic and toxicity evaluations. The anthelminthic assays revealed the more polar fractions to be most active against Ascaridia galli embryos (BuOH | 68% ED | c = 500 µg/ml and EtOAc | 65% ED | c = 500 µg/ml) and Caenorhabditis elegans adult worms (BuOH | 49% WMT | c = 150 µg/ml and EtOAc | 74% WMT | c = 150 µg/ml) suggesting the fraction’s constituents possess dual anthelmintic activity against multiple life-cycle stages (i.e., eggs, worms) of helminths. Additionally, the BuOH fraction was non-cytotoxic to human cell-lines. Subsequent FCC and SEC derived subfractions were submitted to the anthelmintic assay workflow and the enriched subfractions B1 and E3.8, phytochemically assigned as 11-β,13-dihydrolactucin and luteolin, demonstrated bioactivity against the embryo phenotype (B1 | 58% ED | c = 1.8 µM and E3.8 | 46% ED | c = 1.7 µM) within range of the flubendazole control. Furthermore, luteolin was found to inhibit C. elegans egg hatching (luteolin | 65% EH | c = 10 µM | t = 10 h) within the range of the control albendazole. Both identified anthelmintic phytochemicals were found to affect tubulin polymerisation at a concentration of c = 50 µM. Together with in silico virtual screening studies, these results suggest microtubule stabilisation as a possible anthelmintic target and mechanism of action. This work effectively advocates the consideration of C. alpina extracts and fractions for the development of herbal therapeutics against parasitic helminths.
Quantum-inspired K-nearest neighbors classifier for enhanced printer source identification in forensic document analysis
Authors: Darwish Saad M. , Ali Raad A. , Elzoghabi Adel A. 
Published: February 2025

Abstract
Document source identification in printer forensics focuses on determining the source printer of a document by analyzing characteristics such as printer model, serial number, defects, or unique artifacts. This is crucial in forensic investigations involving counterfeit documents or anonymous threats. However, identifying consistent patterns across different printers remains challenging, especially when perpetrators attempt to obscure these artifacts. Machine learning models in this field must identify discriminative features that differentiate printers while minimizing noise. In particular, choosing an appropriate distance metric for K-Nearest Neighbors (KNN) classifiers is critical and requires experimentation. This study proposes a quantum-inspired approach to improve KNN’s performance in printer source identification. By exploring alternative number of neighbors (K), quantum-inspired computing can optimize feature space calculations, even in noisy conditions. This allows the system to iteratively refine and select the optimal K value based on classification performance, ensuring that the best K is identified for the specific dataset and task. The system utilizes the Grey Level Co-occurrence Matrix (GLCM) for feature extraction, which is robust to changes in rotation and scale. Experimental results demonstrate that the Quantum-inspired KNN (QKNN) classifier outperforms classical KNN, achieving higher accuracy in identifying subtle printing artifacts, even under variable conditions.
Association between parental education level and intelligence quotient of children referred to the mental healthcare system: a cross-sectional study in Poland
Authors: Sajewicz-Radtke Urszula , Łada-Maśko Ariadna , Olech Michał , Jurek Paweł , Bieleninik Łucja , Radtke Bartosz M. 
Published: February 2025

Abstract
Considering the gap in understanding of the link between parental education and child intelligence quotient (IQ), our study aimed to investigate the association between parental education and the IQ of children referred to the mental healthcare system, explore which parent’s education level is more influential, and examine the impact of the child’s age and sex on these relationships. This cross-sectional study included 80,303 children aged 3–18 years who were referred to the mental healthcare system between 2018 and 2023. We predefined IQ composite score (Full IQ Scale), as measured by the Stanford Binet 5 Intelligence Scale, Fifth Edition (SB-5) as the primary outcome; the remaining SB-5 composite scores were the secondary outcomes. Linear regression analysis was performed using staircase coding for ordinal predictors with several binary independent variables. A significant correlation was found between parental education levels and IQ of the sampled children, with higher levels of parents’ education predicting higher IQ scores, particularly with mother’s education explaining 18.23% of the variance in children’s overall intelligence. No significant interaction was observed between parental education and child’s sex in predicting child IQ. However, a significant interaction was observed with age, showing that IQ decreases with age in children of parents with lower education, while it increases with age in children of parents with higher education. Our study underscores the pivotal influence of parental education on the IQ levels of children referred to mental healthcare services. Maternal education level was a stronger predictor of child IQ, potentially because mothers tend to be the primary caregivers. These findings suggest the need for targeted support programs for caregivers, particularly those with lower education levels, to facilitate the early detection of developmental challenges. Integrated education and healthcare efforts are crucial for equitable mental healthcare access.
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Authors: Bischoff-Ferrari Heike A. , Gängler Stephanie , Wieczorek Maud , Belsky Daniel W. , Ryan Joanne , Kressig Reto W. , Stähelin Hannes B. , Theiler Robert , Dawson-Hughes Bess , Rizzoli René , Vellas Bruno , Rouch Laure , Guyonnet Sophie , Egli Andreas , Orav E. John , Willett Walter , Horvath Steve 
Published: February 2025

Abstract
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per day) and/or omega-3 (1 g per day) and/or a home exercise program on four next-generation DNA methylation (DNAm) measures of biological aging (PhenoAge, GrimAge, GrimAge2 and DunedinPACE) over 3 years. Omega-3 alone slowed the DNAm clocks PhenoAge, GrimAge2 and DunedinPACE, and all three treatments had additive benefits on PhenoAge. Overall, from baseline to year 3, standardized effects ranged from 0.16 to 0.32 units (2.9–3.8 months). In summary, our trial indicates a small protective effect of omega-3 treatment on slowing biological aging over 3 years across several clocks, with an additive protective effect of omega-3, vitamin D and exercise based on PhenoAge.