bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Role of DICER1 Mutations in Ovarian Sex Cord-Stromal Tumors: A Retrospective Analysis and Implications for Surveillance
Authors: Yıldırım Ülkü Miray , Dalay Doğa , Dural Ozlem , Yilmaz Ismail , Karakurt Neslihan , Eroğlu Egemen , Önder Semen , Schultz Kris Ann P. , Kebudi Rejin 
Published: October 2023

Objective: Ovarian sex cord-stromal tumors (OSCSTs) are a rare and heterogeneous group, accounting for less than 1% of all malignancies and about 10% of ovarian tumors in childhood and adolescence. Some OSCSTs have been associated with germline pathogenic DICER1 variations. This study aims to determine the incidence of DICER1 pathogenic variations in a small cohort of OSCSTs and evaluate the clinicopathological features and patient outcomes.
Material and Methods: We retrospectively reviewed the medical records of the patients diagnosed with OSCSTs between 2014-2021. Molecular genetic sequencing of the tumor samples to detect a RNase IIIb domain hot spot mutation in DICER1 was performed in five patients.
Results: Molecular genetic sequencing of the tumor samples revealed a DICER1 gene mutation in exon 27 c.5437G>C (p.E1813Q) in a patient with Sertoli-Leydig cell tumour.
Conclusions: Although our study included a small number of patients, our findings highlight the importance of knowing the possible association between OSCSTs and pathogenic germline DICER1 variants since detecting this mutation may provide the opportunity for surveillance of related conditions that could improve long-term outcomes and survival, and also enable screening of family members.
Atenção Primária à Saúde no controle das infecções do trato urinário em gestantes
Authors: Nascimento Bianca Thaís Silva do , Laurentino Adilma da Silva , Batista Suênia de Sousa Silva , Silva Thiago Antonio da , Cavalcanti Elismar de Souza , Silva Marcelo Flávio Batista da , Araújo José Natannael Moreira de , Melo Andréia Tenório Bezerra de , Torres Viviane Cavalcanti de , Freitas Eduardo dos Santos , Assis José Joceilson Cruz de , Muniz Marciely , Melo Evellyne Augusto , Silva Flaviane Silva da , Melo Eduarda Augusto 
Published: October 2023

Este artigo tem como evidenciar a atuação da APS no controle de ITU´s e prevenção de complicações. Com a finalidade de alcançar respostas ao seguinte questionamento: “Qual o papel da APS no controle das ITU´s em gestantes”. Foi realizada por meio de consultas nas bases de dados indexadas, com o cruzamento dos descritores em português “Infecção do trato urinário”, “Gestante”, “controle” e “Atenção Primária à Saúde”, através do operador booleano “AND”. Para compor a revisão, foram analisados 27 artigos. Durante o período gestacional é grande a vulnerabilidade na qual as mulheres estão expostas, principalmente pelas patologias bacterianas e infecciosas devido às mudanças anatômicas e fisiológicas que o processo da gravidez ocasiona, onde é mais frequentemente encontrada nas gestantes. as medidas adotadas pela APs mediantes a assistência ao controle da infecção do trato urinário, está no pre-natal, co m o objetivo de prevenir possíveis complicações clínicas para a mãe e o bebê, ressaltando da importância da detecção precoce e tratamento correto das ITU´s, sejam eficazes no período gravídico, torna-se necessário o acesso à informação de maneira que à gestante compreenda.
Radical-Scavenging Effect, Ferric Reducing Ability and Phytochemical Analysis of Urtica urens (L.) and Mercurialis annua (L.)
Authors: Zouhra Doukkali , El Jemli Meryem , Bouyahya Abdelhakim , Goh Khang Wen , Paneerselvam Ganesh Sritheran , Bahia Belatar , Cherrah Yahia , Alaoui Katim 
Published: October 2023

Important Moroccan medicinal plants known for their food and medicinal potential include Urtica urens and Mercurialis annua. We examined the antioxidant activity of the methanolic and aqueous extracts by several in vitro systems of the assay, namely the ferric reducing/antioxidant power (FRAP) assay, the DPPH radical-scavenging activity, and the ABTS free radical-scavenging capacity. In addition, all active extracts were subjected to phytochemical screening to determine the key groups of chemicals implicated in their therapeutic activity. Total phenolic and flavonoid concentrations were also measured to see how they affected the antioxidant properties of the plant extracts. The extracts of Urtica urens and Mercurialis annua were found to have different levels of antioxidant effect in the systems tested. Based on the three different antioxidant assays, the Mercurialis annua extracts showed the highest values of antioxidant ability, based on the three used assays. Phytochemical testing of studied extracts revealed the presence of flavonoids, anthocyanins, and tannins. Total phenol and flavonoid contents were shown to provide the highest association with different antioxidant methods. The present study provides evidence that the extracts of Urtica urens and Mercurialis annua are a potential source of natural antioxidants, and this justifies their uses in Moroccan traditional medicine.
Update on Remdesivir in the Treatment of Novel Coronavirus Pneumonia
Authors: Feng Huang , Lakshmi K. Vijaya , Ng Chin Tat , Sasikumar Murthy , Arip Masita , Hassan Masriana , Chin Voon Kin , Rajagopal Mogana , Fatokun Omotayo , Parvathi N. , Selvaraja Malarvili 
Published: October 2023

Worldwide epidemic prevention and control remain under significant stress due to the global novel coronavirus disease 2019 (COVID-19) pandemic and the ongoing emergence of variants like Omicron. The total confirmed COVID-19 cases globally as of now topped 620 million, while the total number of fatalities exceeded 6.6 million. The screening, drug discovery, and clinical development of novel treatments are still the hottest subjects in the treatment of COVID-19, and scientists throughout the world are dedicated to identifying prospective therapeutic agents to treat COVID-19 patients, including the new uses of old medications. Remdesivir, a COVID-19 therapeutic medication developed by Gilead Sciences, exerts antiviral effects by suppressing the RNA-dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Remdesivir has maintained high inhibitory activity against all existing SARS-CoV-2 variants, including the Omicron variant. We systematically retrieved Web of Science, CNKI, PubMed, and Clinicaltrials.gov to gather information related to Remdesivir on COVID-19 treatment. In this review, we summarized and reviewed the drug targets for COVID-19 management, especially the mechanism of action and research progress of Remdesivir. More importantly, the outcome of current clinical trials of Remdesivir alone and when combined with other drugs for COVID-19 management was analyzed, and the limitations and clinical significance of each clinical trial were evaluated. From this review, we can understand the development progress of Remdesivir for COVID-19 management, deepens the current understanding of Remdesivir research status, and gives us some inspiration for better drug use in COVID-19 management.
PROFILING OF CLINICAL DYNAMICS OF TYPE 2 DIABETES MELLITUS IN PATIENTS: A PERSPECTIVE REVIEW
Authors: Ikwuka Aloysius Obinna , Omoju Daniel Inioluwa , Mahanera Ousainou K 
Published: October 2023

Type 2 diabetes mellitus (T2DM), also known as Non-Insulin Dependent Diabetes Mellitus (NIDDM) is one of the common metabolic disorders in the world. T2DM accounts for around 90% of all cases of diabetes mellitus, afflicting millions worldwide. It is a significant global health burden with a steadily increasing prevalence. In T2DM, the response to insulin is diminished, and this is defined as insulin resistance. Risk factors for T2DM are diverse. Some are modifiable, and others are not. Modifiable risk factors include overweight/obesity, lack of exercise or physical inactivity, poor nutrition, etc. Non-modifiable risk factors include age, ethnicity/race, family history, history of gestational diabetes mellitus, etc. The starting points and mainstays of treatment for T2DM are diet and lifestyle modifications such as increased physical activity and stoppage of smoking. In addition to the diet and lifestyle modifications, drugs are also used in the management of T2DM. This study aimed to profile the clinical dynamics of type 2 diabetes mellitus in patients. Current literatures from different databases including MEDLINE, PubMed, EMBASE, CINAHL, Google Scholar, etc. on the topic were searched online and reviewed.
Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants
Authors: Byrski Adam , Kopernik Magdalena , Major Łukasz , Kasperkiewicz Katarzyna , Dyner Marcin , Lackner Juergen M. , Lumenta David , Major Roman 
Published: October 2023

Purpose
The research was focused on determining basic mechanical properties, surface and phase structure taking into consideration basic cytotoxicity analysis towards human cells.
Methods
Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing, and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing.
Results
Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance
Conclusions
Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.
Quantitative evaluation of stereoscopic augmented reality visualization using an optical see-through head-mounted display
Authors: Żuk Magdalena , Majak Marcin , Szczur Izabela , Popek Michał , Świątek-Najwer Ewelina 
Published: October 2023

Purpose
The objectives of the current study were to propose a calibration method for accurate augmented reality visualisation using an optical see-through head-mounted display, and to qualitatively evaluate visualisation accuracy for the application in computer assisted surgery.
Methods
An adaptation of stereo single-point active alignment method was proposed as the calibration procedure together with verification Three tests were performed: display of points in 3D space, on the plane, and on the surface of a skull phantom on inexperience users ( 5 participants) and experienced users ( 17 participants).
Results
The highest accuracy of visualization was obtained for skull phantom visualisation for an inexperienced user (3.00 mm, std 0.75 mm), while the lowest accuracy was obtained in a 3D visualisation test for an inexperienced user (22.95 mm, std 18.04 mm). The largest error was related to the depth component and amounted to 18.49 mm, std 18.10 mm for an inexperienced user.
Conclusions
It is possible to achieve relatively high visualisation accuracy (less than 5 mm for visualisation in space) for selected users but providing it for the group of inexperienced users seems to remain a major challenge. The accuracy of point indication can be substantially and statistically significantly increased by visualising objects on surfaces. The proposed methods and obtained results can serve as a basis for further implementation of augmented reality visualisation on an optical see-through head-mounted display in applications requiring high-quality augmented reality guidance of manual tasks.
PERANAN BADAN USAHA MILIK DESA DI MASA PANDEMIC COVID-19 DALAM UPAYA MENINGKATKAN PEREKONOMIAN MASYARAKAT DI DESA SUKALAKSANA KABUPATEN GARUT (KAJIAN HUKUM EKONOMI SYARIAH)
Authors: Gaussian Gini , Abu Bakar Azmi Al-Atiq 
Published: October 2023

Abstrak

Kesejahteraan masyarakat sangat penting dalam upaya pembangunan dan pemberdayaan masyarakat. Kebijakan pemerintah dengan dibentuknya Bumdes untuk mensejahterakan masyarakat desa dalam bidang perekonomian dengan memanfaatkan potensi. Tujuan dari penelitian ini adalah untuk mengetahui peranan Badan Usaha Milik Desa dalam meninggkatkan perekonomian masyarakat pada masa pandemic covid-19 di Desa Sukalaksana berdasarkan ekonomi Islam. Metode yang di gunakan untuk menganalisis data dalam penelitian ini adalah deskriptif kualitatif dengan pengumpulan data kepada para narasumber melalui teknik observasi dan wawancara. Berdasarkan analisis dilihat dari peningkatan jumlah penghasilan masyarakat setelah bekerjasama dengan pihak Badan Usaha Milik Desa Binalaksana dan sebagian masyarakat Desa Sukalaksana yang terkena dampak pandemic Covid-19 disalurkan oleh pihak pemerintah desa untuk bekerja di Bumdes Binalaksana dalam upaya penurunan angka pengangguran di masa pandemic Covid-19. Menurut kajian hukum ekonomi syariah peran Badan Usaha Milik Desa di Desa Sukalaksana telah sesuai dengan nilai-nilai Islam, hal itu dilihat dari tujuan utama dari berdirinya Bumdes Binalaksana untuk mensejahterakan masyarakat serta membantu masyarakat yang membutuhkan bantuan finansial serta motto yang diterapkan yaitu “Iuran Sambil Ibadah”. Kesimpulan dari penelitian ini adalah Peran Badan Usaha Milik Desa Pada Masa Pandemic Covid-19 di Desa Sukalaksana telah menjadikan masyarakat sejahtera melalui bidang ekonomi dengan berbagai unit usaha yang berjalan yang sesuai dengan nilai-nilai Islam.

Kata Kunci: BUMDes, Hukum Ekonomi Syariah
The Landscape Urban Planning Approach for Improving Urban Air Quality, Case Study of Algiers, Algeria
Authors: SOUICI Belgacem 
Published: October 2023

Gardens and urban parks are areas of great importance for the support of the urban ecosystem, in addition to their psychological and therapeutic values; they provide the urban environment with a large amount of oxygen. Trees produce oxygen through the operation of photosynthesis; one hectare of eucalyptus tree annually produces oxygen for 37 to 80 people, and absorbs 25, 000 kg of carbon dioxide for the same period of time. Wooded zone in urban areas significantly improve and purify the quality of the air that we breathe and make living environments healthier. A recent study carried out by the World Health Organization (WHO) revealed that the MENA region (Middle East and North Africa) is one of the most polluted in the world, air polluted by particulate matter smaller than 2.5µm (PM2.5). For the case of Algiers, measurements were taken during the first two months of the year 2023 by the station of the United States Embassy in Algiers, showed that daily average of 14 µm/m3 for particulate matter less than 2.5 µm/m3 and a daily average of 50 for the IQA, air quality index. According to the US EPA's NAAQS, any measurement above 12.0 μg/m 3 (US AQI 50) may be hazardous to human health. Several factors of an exogenous and endogenous nature act directly on the quality of the air in large urban concentrations, CO2 emissions, modes and nature of urban mobility, uncontrolled urban sprawl. High population densities, urban forms, morphology, the size of cities, which getting larger and larger, the choice of urbanization models, and the surface of wooded areas, all are, factors responsible for air quality. This study will be particularly interested in the contribution of gardens, parks and wooded areas in improving air quality, and consequently on the quality of the living environment in urban areas. In this respect, and to understand the situation, we take the city of Algiers as a case study. The field work will allow us to understand in a qualitative and quantitative way the contribution of the tree and the choice of tree species, understanding co-relation between landscape architecture decision and results obtained on the urban air quality, and try to research on how it would possible to improve air quality in urban areas by using trees new essence.
City Sediments in Beirut: An Urban Ecology Perspective
Authors: Hindi Nadine 
Published: October 2023

Cities are products of urbanization processes, economic changes, technology and climate change. Adversely, in specific contexts, they are affected by wars’ enduring physical effect, long after armed conflicts are over. Hence cities are perceived as dynamic organisms, in continuous change of spatial abandonment, neglect and regeneration process, unfolding a continuum of space and time. In tandem between urban ecology and the urban history specificities, this paper addresses Beirut as a case study in its actual condition, and the different representations of the informal resurgence of green areas. It follows a methodology of identification and mapping of the different urban sediments which constituted over time potential reservoirs for urban ecology. These include previous war demarcation line, train tracks traces, cemeteries, destroyed wheat silos following the 2020 port explosion and other liminal spaces. This approach brings in a new perspective for approaching urban ecology differently according to the urban contexts historiography
The Level of COVID-19 Fear in Pregnant Women and Affecting Factors
Authors: BEYDAĞ Kerime Derya , KARABULUTLU Özlem 
Published: October 2023

Objective: The objective of this research is to determine the COVID-19 fear levels of pregnant women during the pandemic period and to reveal the factors that affect their fear levels.
Methods: This descriptive and cross-sectional study was conducted with 440 married pregnant women between August 1st and December 31st, 2020. The research data were obtained using the COVID-19 Fear Scale and the demographic questionnaire prepared in line with the relevant literature.
Results: The mean COVID-19 Fear Scale score of pregnant women was found as 22.25 ± 6.60 (min:7, max:35). COVID-19 fear was found to be higher among the pregnant women, who do not have a child, who stated that they needed psychological support, who were in the 4th-6th month of their pregnancy, who stated that they always feel fear whenever they go out, who restrict home visits, who are afraid of becoming infected by COVID-19, who are concerned about their babies getting harmed by COVID-19, who have had someone among their kith and kin that became infected by COVID-19, who are worried about giving birth in a health institution, who were not able to go to their prenatal check-ups, who are afraid of losing their babies, who are afraid of giving birth prematurely and who are afraid of giving birth to a baby that incurs a disability due to COVID-19.
Conclusion: Up-to-date information should be shared with pregnant women during the pandemic period ensuring that their fear levels are alleviated.
Gebelerde Evlilik Doyumunun Prenatal Bağlanmaya Etkisi
Authors: ÜNAL TOPRAK Filiz , TURAN Zekiye 
Published: October 2023

Amaç: Çalışmada, gebelerde evlilik doyumu ve prenatal bağlanmayı etkileyen faktörler ile evlilik doyumunun prenatal bağlanma üzerine etkisini incelemek amaçlanmıştır.
Yöntem: Çalışma tanımlayıcı tipte yapılmıştır. Çalışmanın verileri 01 Nisan 2021- 30 Haziran 2021 tarihleri arasında örnekleme dâhil edilme kriterlerine uyan ve araştırmaya katılmayı kabul eden toplam 252 gebeden toplanmıştır. Veriler kişisel bilgi formu, Prenatal Bağlanma Envanteri (PBE) ve Evlilik Doyum Ölçeği (EDÖ) kullanılarak toplanmıştır. Verilerin değerlendirilmesinde sayı ve yüzdelik dağılımlar, ortalama, non-parametrik testler (Kruskal Wallis, Mann Whitney-U) ile sürekli değişkenler arasındaki ilişkiyi incelemede Spearman korelasyon analizi kullanılmıştır.
Bulgular: Gebelerin ekonomik durumu (p=0.027), evlenme yaşı (p=0.030), eşi ile tanışma şekli (p=0.006), gebeliğin planlanma durumu (p=0.017), gravidite (p=0.003) ve gebelik trimesteri (p=0.033) prenatal bağlanmalarını etkilemektedir (p
The Effect of Neutrophil/Lymphocyte Ratio and Mean Platelet Volume on the use of Antivenom in Snake Bites and Scorpion Stings
Authors: TALAY Mehmet Nur , ORHAN Özhan 
Published: October 2023

Objective: We evaluated the distribution, use of antivenom, treatments applied during the follow-ups, and effects on the use of NLR and MPV antivenom in cases of snake bites and scorpion stings followed in the paediatric intensive care unit (PICU) and the effects of these cases on the length of stay in the intensive care unit and hospital.
Materials and Methods: Demographic characteristics of the patients followed in the PICU and the severity of their clinical findings at admission, antivenom use after snake and scorpion bites were retrospectively examined from the clinical course in the hospital automation system and archived file records.
Results: Of 38 patients who were followed up in the PICU for snake and scorpion bites, half were followed up for snake bites and half for scorpion bites. Antivenom treatment was applied according to the clinical stage. There was a positive correlation between antivenom-administered patients and NLR (p
Investigation of COVID-19 Anxiety Levels of Emergency Workers
Authors: ÜSTÜNTAŞ Onur , KAVALCI Cemil 
Published: October 2023

Objective: The coronavirus pandemic has affected human and societal psychology worldwide. The Coronavirus Anxiety Scale is used to detect dysfunctional anxiety about the COVID-19 pandemic. In this study, our aim was to determine the anxiety levels of workers of the our emergency serrvices during the pandemic.
Material Methods: The Coronavirus Anxiety Scale questionnaire was applied to emergency workers. According to the scores obtained from the questionnaire, the participants were divided into two groups: those with anxiety (Group 1) and those without anxiety (Group 2). The Mann-Whitney U test was used to compare two independent groups for continuous data, and Pearson’s chi-square test was used for frequency data. A p value of 0.05). There was also no statistically significant difference between the groups in terms of having previously contracted COVID-19, receiving a COVID-19 vaccine, to get psychiatric support before or during the pandemic, and having a deceased relative due to the pandemic.
Conclusion: During the COVID-19 pandemic, anxiety rate is 8.1% in emergency workers. Anxiety rates were higher in female, non-alcohol users and non-smokers during the pandemic.
Connection between Polytropic Index and Heating
Authors: Livadiotis G. , McComas D. J. 
Published: October 2023

Abstract
The paper derives the one-to-one connecting relationships between plasma heating and its polytropic index, and addresses the consequences through the transport equation of temperature. Thermodynamic polytropic processes are classified in accordance to their polytropic index, the exponent of the power-law relationship of thermal pressure expressed with respect to density. These processes generalize the adiabatic one, where no heating is exchanged between the system and its environment. We show that, in addition to heating terms, the transport equation of temperature depends on the adiabatic index, instead of a general, nonadiabatic polytropic index, even when the plasma follows nonadiabatic processes. This is because all the information regarding the system's polytropic index is contained in the heating term, even for a nonconstant polytropic index. Moreover, the paper (i) defines the role of the polytropic index in the context of heating; (ii) clarifies the role of the nonadiabatic polytropic index in the transport equation of temperature; (iii) provides an alternative method for deriving the turbulent heating through the comparably simpler polytropic index path; and, finally, (iv) shows a one-component plasma proof-of-concept of this method and discusses the implications of such derived connecting relationships in the solar wind plasma in the heliosphere.