bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of preventive parental education delivered from pregnancy to 1 month postpartum for improving infant sleep and parental sleep and depression: a systematic review protocol
Authors: Matsunaka Eriko , Ooshige Narumi , Ueki Shingo , Morokuma Seiichi 
Published: February 2024

Objective:
This review aims to evaluate the effectiveness of preventive parental education on infant sleep problems, delivered from pregnancy to 1 month postpartum, on infant sleep, postpartum parental sleep, and depression.

Introduction:
Infant sleep problems are likely to persist into childhood if not treated and are associated with difficulties in later development. Parents of children with sleep problems had lower sleep quality and emotional regulation than those without sleep problems. Chronic sleep deprivation and fragmentation increases the risk of maternal depression. Therefore, preventive parental education regarding infant sleep problems can improve the long-term well-being of both children and their parents.

Inclusion criteria:
Experimental and quasi-experimental study designs, including preventive parental education about infant sleep problems delivered from pregnancy to 1 month postpartum, will be considered. The outcomes will be infants’ sleep, postpartum parental sleep, and parental depression.

Methods:
MEDLINE (Ovid), CINAHL (EBSCOhost), PsycINFO (Ovid), the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (Japan Medical Abstracts Society) will be searched without restrictions on language or date of publication. Eligible studies will be critically appraised, and data will be extracted by 2 independent reviewers using the JBI methodology. The studies will be pooled for statistical meta-analysis. Where statistical pooling is not possible, the findings will be presented in narrative format. We will use the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach to assess the certainty in the quality of evidence.

Review registration:
PROSPERO CRD42023430562
A Multiscale Euler–Lagrange Model for High-Frequency Cavitation Noise Prediction
Authors: Wang Xincheng , Song Mingtai , Cheng Huaiyu , Ji Bin , Li Linmin 
Published: February 2024

Abstract
To simulate the microscale bubble distribution and its effect on high-frequency cavitation noise, we present a two-way transition and coupling Euler–Lagrange model. The model accounts for both cavity fission and environmental nucleation as sources of microscale bubbles, which are limited in the traditional mesh-based Euler models. We evaluate the model with the experimental data of truncated NACA0009 hydrofoil as well as the measured bubble size distributions, showing satisfactory results for velocity distribution, cavity patterns, and power law scalings of bubble size. Based on an acoustic analogy, we find that the model produces sound waves with smaller wavelengths and higher frequencies than the Euler model, which are mainly attributed to two factors: (1) microscale bubbles with high natural frequency and (2) intense multiple cavity collapse/rebound behavior. This model is promising for predicting the full-spectrum of cavitation noise.
Proactive therapeutic monitoring of dalbavancin concentrations in the long-term management of chronic osteoarticular/periprosthetic joint infections
Authors: Cattaneo Dario , Fusi Marta , Galli Lucia , Genovese Camilla , Giorgi Riccardo , Matone Maddalena , Merli Stefania , Colaneri Marta , Gori Andrea 
Published: February 2024

ABSTRACT

Here, we describe the use of proactive therapeutic drug monitoring (TDM) to individualize the optimal timing of drug injections in 16 adult patients with chronic osteoarticular infections receiving a median of 7 injections of dalbavancin (up to 12 injections in 15 months). Dalbavancin injections were repeated at medians of 39–47 days, with infusion intervals ranging from 26 to 69 days. TDM can facilitates a precise, targeted use of dalbavancin for infections requiring prolonged treatments.
Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity
Authors: Yu Shuang-Shuang , Tang Rong-Chun , Zhang Ao , Geng Shijin , Yu Hengxiang , Zhang Yan , Sun Xiu-Yuan , Zhang Jun 
Published: February 2024

ABSTRACT

Type I and type II IFNs are important immune modulators in both innate and adaptive immunity. They transmit signaling by activating JAK-STAT pathways. Sirtuin 1 (SIRT1), a class III NAD
+
-dependent deacetylase, has multiple functions in a variety of physiological processes. Here, we characterized the novel functions of SIRT1 in the regulation of type I and type II IFN-induced signaling. Overexpression of SIRT1 inhibited type I and type II IFN-induced interferon-stimulated response element activation. In contrast, knockout of
SIRT1
promoted type I and type II IFN-induced expression of ISGs and inhibited viral replication. Treatment with SIRT1 inhibitor EX527 had similar positive effects. SIRT1 physically associated with STAT1 or STAT3, and this interaction was enhanced by IFN stimulation or viral infection. By deacetylating STAT1 at K673 and STAT3 at K679/K685/K707/K709, SIRT1 downregulated the phosphorylation of STAT1 (Y701) and STAT3 (Y705).

Sirt1
+/−

primary peritoneal macrophages and

Sirt1
+/−

mice exhibited enhanced IFN-induced signaling and antiviral activity. Thus, SIRT1 is a novel negative regulator of type I and type II IFN-induced signaling through its deacetylase activity.

IMPORTANCE
SIRT1 has been reported in the precise regulation of antiviral (RNA and DNA) immunity. However, its functions in type I and type II IFN-induced signaling are still unclear. In this study, we deciphered the important functions of SIRT1 in both type I and type II IFN-induced JAK-STAT signaling and explored the potential acting mechanisms. It is helpful for understanding the regulatory roles of SIRT1 at different levels of IFN signaling. It also consolidates the notion that SIRT1 is an important target for intervention in viral infection, inflammatory diseases, or even interferon-related therapies.
Genome sequence and annotation of
Arthrobacter globiformis
phage Vulpecula (AS1) isolated from soil in Dahlonega, Georgia
Authors: Chuhran Lily , Whitlow Chase , Teems Carson , Kanak Alison , Webb Shane A. 
Published: February 2024

ABSTRACT

Vulpecula, a temperate bacteriophage collected from soil in Dahlonega, Georgia using host
Arthrobacter globiformis
, is an AS1 subcluster virus of 37,766 bp (67.7% GC). Genome annotation suggests 64 open reading frames, no predicted tRNA genes, and ~98% sequence similarity to AS1 phages Ruchi (from GA) and Jamun (New Hampshire).
Randomised, blinded, cross-over evaluation of the palatability of and preference for different potassium binders in participants with chronic hyperkalaemia in the USA, Canada and Europe: the APPETIZE study
Authors: Wheeler David C , Søndergaard Henning , Gwynn Cathy , Hedman Katarina , Hedberg Jonatan , Allum Alaster , Chung Hui-Lan , Någård Mats , Stjernlöf Gunilla , Wittbrodt Eric , Kim Jennifer , Morris Jon 
Published: February 2024

ObjectivesTraditional potassium (K+) binders for treating hyperkalaemia are unpalatable and poorly tolerated. Newer K+binders are reportedly better tolerated; however, no published data describe their palatability, a determinant of long-term adherence. This study evaluated the palatability of and preference for three K+binders: sodium and calcium polystyrene sulfonate (S/CPS), sodium zirconium cyclosilicate (SZC) and calcium patiromer sorbitex (patiromer).DesignPhase 4, randomised, participant-blinded, cross-over study. Participants were randomised to one of six taste sequences and, using a ‘sip and spit’ approach, tasted each K+binder before completing a survey.Setting17 centres across the USA, Canada and European Union.Participants144 participants with chronic kidney disease, hyperkalaemia and no recent use of K+binders.Main outcome measuresFor the primary (USA) and key secondary (Canada and European Union) endpoints, participants rated palatability attributes (taste, texture, smell and mouthfeel) and willingness to take each K+binder on a scale of 0–10 (rational evaluation). Feelings about each attribute, and the idea of taking the product once daily, were evaluated using a non-verbal, visual measure of emotional response. Finally, participants ranked the K+binders according to palatability.ResultsIn each region, SZC and patiromer outperformed S/CPS on overall palatability (a composite of taste, texture, smell and mouthfeel), based on rational evaluation and emotional response. Taking the product once daily was more appealing for SZC and patiromer, creating greater receptivity than the idea of taking S/CPS. The emotional response to mouthfeel had the strongest influence on feelings about taking each product. In each region, a numerically greater proportion of participants ranked SZC as the most preferred K+binder versus patiromer or S/CPS.ConclusionsPreference for more palatable K+binders such as SZC and patiromer may provide an opportunity to improve adherence to long-term treatment of hyperkalaemia.Trial registration numberNCT04566653.
Primary lateral sclerosis: application and validation of the 2020 consensus diagnostic criteria in an expert opinion-based PLS cohort
Authors: Witzel Simon , Micca Veronika , Müller Hans P , Huss André , Bachhuber Franziska , Dorst Johannes , Lulé Dorothée E , Tumani Hayrettin , Kassubek Jan , Ludolph Albert C 
Published: February 2024

BackgroundValidation of the 2020 consensus criteria for primary lateral sclerosis (PLS) is essential for their use in clinical practice and future trials.MethodsIn a large cohort of patients diagnosed with PLS by expert opinion prior to the new criteria with detailed clinical baseline evaluation (n=107) and longitudinal follow-up (n=63), we applied the new diagnostic criteria and analysed the clinical phenotype, electromyography (EMG), diagnostic accuracy and prognosis, adding neurofilaments and MRI as potential biomarkers.ResultsThe criteria for definite PLS were met by 28% and those for probable PLS by 19%, whereas 53% did not meet the full criteria at baseline, mainly due to the time, EMG and region criteria. Patients not meeting the criteria had less generalised upper motor neuron involvement but were otherwise similar in demographic and clinical characteristics. All patients with definite and probable PLS maintained PLS diagnosis during follow-up, while four patients not meeting the criteria developed clinical lower motor neuron involvement. Definite PLS cases showed improved survival compared with probable PLS and patients who did not meet the criteria. Despite a clinical PLS phenotype, fibrillation potentials/positive sharp waves and fasciculations in one or more muscles were a frequent EMG finding, with the extent and prognostic significance depending on disease duration. Serum neurofilament light and a multiparametric MRI fibre integrity Z-score correlated with clinical parameters and were identified as potential biomarkers.ConclusionValidation of the 2020 PLS consensus criteria revealed high diagnostic certainty and prognostic significance, supporting their value for research and clinical practice.
Percutaneous auricular neuromodulation (nerve stimulation) for the treatment of pain following total knee arthroplasty: a randomized, double-masked, sham-controlled pilot study
Authors: Ilfeld Brian M , Finneran John J , Alexander Brenton , Abramson Wendy B , Sztain Jacklynn F , Ball Scott T , Gonzales Francis B , Abdullah Baharin , Cha Brannon J , Said Engy T 
Published: February 2024

Background
Percutaneous auricular nerve stimulation (neuromodulation) is an analgesic technique involving the percutaneous implantation of multiple leads at various points on/around the ear followed by the delivery of electric current using an external pulse generator. A device is currently available within the USA cleared to treat symptoms from opioid withdrawal, and multiple reports suggest a possible postoperative analgesic effect. The current randomized, controlled pilot study was undertaken to (1) determine the feasibility and optimize the protocol for a subsequent definitive clinical trial and (2) estimate the treatment effect of auricular neuromodulation on postoperative pain and opioid consumption following total knee arthroplasty.

Methods

Within the recovery room following primary, unilateral, total knee arthroplasty, an auricular neuromodulation device (NSS-2 Bridge, Masimo, Irvine, California, USA) was applied using three percutaneous leads and one ground electrode. Participants were randomized to 5 days of either electrical stimulation or sham stimulation in a double-masked fashion. Participants were discharged with the stimulator
in situ
and removed the disposable devices at home. The dual primary treatment effect outcome measures were the cumulative opioid use (oral oxycodone) and the mean of the “average” daily pain measured with the Numeric Rating Scale for the first 5 postoperative days.

Results
During the first five postoperative days, oxycodone consumption in participants given active stimulation (n=15) was a median (IQR) of 4 mg (2–12) vs 13 mg (5–23) in patients given sham (n=15) treatment (p=0.039). During this same period, the average pain intensity in patients given active stimulation was a median (IQR) of 2.5 (1.5–3.3) vs 4.0 (3.6–4.8) in those given sham (p=0.014). Awakenings due to pain over all eight postoperative nights in participants given active stimulation was a median (IQR) of 5 (3–8) vs 11 (4–14) in those given sham (p<0.001). No device-related localized cutaneous irritation, systemic side effects, or other adverse events were identified.

Conclusions
Percutaneous auricular neuromodulation reduced pain scores and opioid requirements during the initial week after total knee arthroplasty. Given the ease of application as well as the lack of systemic side effects and reported complications, a definitive clinical trial appears warranted.

Trial registration number

NCT05521516
.
Burnout and attachment in oncology and palliative care healthcare professionals
Authors: Gonçalves Florbela , Gaudencio Margarida , Castelo Branco Miguel , Viana Joaquim 
Published: February 2024

ObjectivesExamine the prevalence of burn-out in health professionals working in a hospital dedicated to patients with cancer. Explore the relationship between attachment style and burn-out in healthcare professionals working in Oncology and Palliative Care.MethodsCross-sectional descriptive and correlational study with a sample of 337 health professionals working in a tertiary hospital dedicated to oncology care. The evaluation protocol included a sociodemographic questionnaire, two burn-out (Copenhagen Burnout Inventory (CBI) and Maslach Burnout Inventory) and attachment (Adult Attachment Scale) scales. Statistical analysis was performed by IBM SPSS Statistics V.25. The tests were performed at a significance level of 5%.ResultsIn the sample, there is a predominance of professionals working in oncology services (76,8%). Comparing professionals who work in oncology services and palliative care, it appears that just over half have high levels of personal burn-out, however the groups do not differ significantly (53.5% vs 56.8%, p=0.619); the same is observed in work-related (p=0.626) and patient-related burn-out (p=0.672). The number of hours per week in which one has the perception that is exposed to suffering is positively correlated with personal, work-related burn-out and exhaustion (p<0.05). Correlating the two burn-out scales in the sample, it is observed that higher levels of personal, work-related and patient-related burn-out are associated with higher levels of emotional exhaustion and depersonalisation, as well as lower levels of personal accomplishment (p<0.001). Considering the correlation between the burn-out dimensions and attachment scale, it appears that high levels of exhaustion, depersonalisation, personal, work-related and patient-related burn-out were associated with higher levels of anxiety (p<0.001). Similar results were found in the palliative care professionals sample.ConclusionsThe constant exposure to the suffering of others places high emotional demands on oncology and palliative care professionals, making them vulnerable to burn-out. Burn-out is a multifactorial process, that involves individual characteristics with environmental effects. There are no significant differences between Oncology and Palliative Care professionals. Higher levels of personal, work-related and patient-related burn-out are associated with higher levels of anxiety. These results suggest that an anxious attachment style increases the risk of burn-out . In the sample, the most important predictor of burn-out was the number of hours per week exposed to suffering. In order to prevent burn-out, there is a growing evidence that suggests mindfulness, exercise, high-quality sleep and pursuit of happiness can improve burn-out in healthcare professionals. This work brings the advantage of using two burn-out assessment scales (particularly CBI scale), in addition to trying to correlate the level of burn-out and attachment in professionals exposed to suffering.
A new approach for spatializing the Canadian National Forest Inventory (SCANFI) using Landsat dense time series
Authors: Guindon Luc , Manka Francis , Correia David L.P. , Villemaire Philippe , Smiley Byron , Bernier Pierre , Gauthier Sylvie , Beaudoin André , Boucher Jonathan , Boulanger Yan 
Published: February 2024

Accurate and fine-scale forest data are essential to improve natural resource management, particularly in the face of climate change. Here, we present SCANFI, the Spatialized CAnadian National Forest Inventory, which provides coherent, 30 m resolution 2020 wall-to-wall maps of forest attributes (land cover type, canopy height, crown closure, aboveground tree biomass, and main species composition). These maps were developed using the NFI photo-plot dataset, a systematic regular sample grid of photo-interpreted high-resolution imagery covering all of Canada's non-arctic landmass. SCANFI was produced using temporally harmonized summer and winter Landsat spectral imagery along with hundreds of tile-level regional models based on a multiresponse k-nearest neighbours and random forest imputation method. This tile-level approach revealed the importance of radiometric variables in predicting vegetation attributes, namely winter radiometry, as the large-scale climate gradients were controlled at the tile-level. SCANFI was validated with rigorous cross-validation analyses, which revealed robust model performance for structural attributes (biomass R2 = 0.76; crown closure R2 = 0.82; height R2 = 0.78) and tree species cover (e.g., Douglas fir R2 = 0.60). SCANFI attributes were also validated with several independent external products, ranging from ground plot-based tree species cover (e.g., black spruce R2 = 0.53) to satellite LiDAR height data products (e.g., crown closure R2 = 0.71). SCANFI total aboveground biomass trends also followed those published by other studies. The methodology presented herein can be used to map time series of these attributes, identify the original training points used to make any given prediction, as well as map additional variables associated with the NFI photo-plots that are challenging to map using traditional remote sensing approaches.
Impurity-doped stable domain walls in spherically symmetric spacetimes
Authors: Bazeia D. , Liao M. A. , Marques M. A. 
Published: February 2024

AbstractIn this work, radially symmetric domain wall solutions in the presence of impurities are investigated for both flat and curved $$D+1$$

D
+
1

spacetimes, with geometry generated by a rotationally invariant background metric. We have examined the constraints placed upon the model by Derrick’s theorem, and found out the Bogomol’nyi bound and equations of the symmetric restriction to this theory. Impurity-doped versions of a $$\phi ^4$$

ϕ
4

model in two dimensions and a model with logarithmic potential in a Schwarzschild background have been explicitly worked out. The resulting configurations have been compared with those found in the homogeneous version of the theory, so that the effect of impurities in the form of solutions may be better appreciated. We have also generalized to higher dimensions some of the results that had been presented in the recent literature. These results relate to the possibility of BPS-preserving impurities, which we have found to still exist in the spacetimes considered in this work. We also investigate ways in which these results may be extended in a curved background.
Investigation of scalar and fermion dark matter in mono-photon production at high-energy colliders
Authors: da Silveira G. Gil , Mateus M. S. 
Published: February 2024

AbstractMany theories about dark matter have emerged due to its strong theoretical appeal in explaining astrophysical phenomena. However, experimental and theoretical particle physics have yet not provided evidence that dark matter is part of the observable Universe. Our work aims to investigate the interaction between Standard Model (SM) fermions and different species of dark matter (DM) particles in high-energy collisions through interaction of a new massive vector mediator, $$Z^{\prime }$$

Z
′

. The production of scalar and fermion DM pairs via fermion annihilation into the new vector boson is investigated near a resonance $$(m_{\chi }\sim M_{Z^{\prime }}/2)$$

(

m
χ

∼

M

Z
′

/
2
)

, where a SM signal from hard photon emission is considered as initial state radiation, namely a mono-photon production. Values of coupling constants between the DM and the SM particles are mapped in contrast to the Planck satellite data for thermal relic density DM computed in the correct framework for the relic density near a resonance, where a weaker suppression of the relic density is expected. We show for the CLIC and LHC kinematic regimes that certain mass ranges and coupling constants of these DM particles are in agreement with the expected relic density near a resonance and are not excluded by collider and astrophysical limits.
Dual CFT on Nariai limit for Kerr–Sen–dS black holes
Authors: Sakti Muhammad Fitrah Alfian Rangga , Burikham Piyabut 
Published: February 2024

AbstractIn this work, we study the Kerr–Sen–de Sitter black hole (BH) in the Nariai limit where the event and cosmological horizon coincide. We show that the near-horizon Kerr–Sen–de Sitter black hole in Nariai limit is a fiber over AdS$$_2$$

2

with an appropriate coordinate transformation, instead of fiber over dS$$_2$$

2

. Hence, we can compute the associated central charge and CFT temperature by using the Kerr/CFT method. It is remarkably exhibited that through Cardy’s growth of states, the Bekenstein–Hawking entropy on cosmological horizon is reproduced. Moreover, we show that the radial equation of the quantum scalar field in J- and Q-pictures on this charged rotating background in Nariai limit can be portrayed in quadratic Casimir operator form with $$SL(2,R)\times SL(2,R)$$

S
L
(
2
,
R
)
×
S
L
(
2
,
R
)

isometry. We also compute the corresponding thermodynamic quantities from CFT to find the absorption cross-section and real-time correlator in J-picture. In Q-picture, we do not find a well-defined CFT description. We then extend the study of quantum scalar field in Nariai limit for Kerr–Newman–dS black hole solution and show that the hidden conformal symmetry on this black hole’s background in J- and Q-pictures is well-defined.