bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Tai Chi combined with music therapy on the cognitive function in older adult individuals with mild cognitive impairment
Authors: Zhou Chunhui 
Published: January 2025

BackgroundWith the global aging population increasing, cognitive impairment among the older adult, particularly Mild Cognitive Impairment (MCI), has garnered remarkable attention. MCI, often a precursor to dementia, presents an opportunity for early intervention. This study investigates the effects of Tai Chi combined with music therapy on the cognitive function in older adult individuals with MCI.MethodsIn this randomized controlled trial, 66 older adult participants with MCI were randomly assigned to one of the following three groups: a Control Group (CG), a Tai Chi Group (TCG), and a Tai Chi Combined with Music Group (TCMG), with 22 participants in each group. Cognitive function was evaluated over a 12-week intervention using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and Stroop Color and Word Test.ResultsBaseline characteristics showed no significant differences among the groups. The TCG and TCMG exhibited significant improvements after 16-week intervention. The participants with TCG group improved in MoCA score (P = 0.005), attention accuracy (P = 0.031), and delayed recall (P = 0.003). The participants with TCMG showed notable enhancements in MoCA (P = 0.000), MMSE (P = 0.001), attention accuracy (P = 0.025), visuospatial and executive functions (P = 0.001), naming (P = 0.014), abstraction (P = 0.020), and delayed recall (P = 0.006). The CG experienced decreased language repetition ability (P = 0.042) and delayed recall (P = 0.030).ConclusionTwelve weeks of Tai Chi combined with music therapy substantially improved cognitive function in older adult individuals with MCI. This combined intervention is more effective than Tai Chi alone, highlighting its potential as a non-pharmacological approach to enhance cognitive health in the aging population.
Seroprevalence against SARS-CoV-2 after booster vaccination in a prison in Alicante (Spain)
Authors: Montagud Ana C. , Moragues Raul , Vicente-Alcalde Nancy , Montagud Emilia , Hurtado-Sánchez José Antonio , Tuells José 
Published: January 2025

BackgroundConfinement conditions in prison communities are associated with increased susceptibility to infectious outbreaks. The COVID-19 pandemic has been characterized by high transmissibility and clinical severity resulting in a high number of infections and deaths worldwide. Vaccination has been a crucial tool in mitigating its devastating effects. The aim of this study is to asses the prevalence of antibodies against the Spike protein of SARS-CoV-2 in vaccinated prisoners and staff at a specific prison in Alicante.MethodsA cross-sectional epidemiological study was designed for the population in scope using a rapid lateral flow immunochromatography serological test, conducted on July 27, 2023. Demographic and clinical variables were collected through a questionnaire. Statistical analysis was performed using the SPSS 29.0 software.ResultsA total of 560 people participated in the study; the predominant profile was men (77.3%) with an average age of 45.7 years. 71.4% of subjects were prisoners and 28.6% were prison staff. Regarding the detection of anti-SARS-CoV-2 antibodies obtained through serological test, 60.9% of the sample gave a positive result. 69.1% of participants received the last dose in 2022 or later and 62.2% received booster doses. The vaccines administered in the last dose were Biontech/Pfizer and Moderna in 88.6% of the cases. 59.5% of sample had suffered from COVID-19 and 67.0% did not have any clinical comorbidity. In the regression analysis, it was observed that the variables with a stronger statistical relationship with presence of anti-SARS-CoV-2 antibodies were: the number of years since last vaccine dose was received (aOR: 0.08; 95%CI: 0.05; 0.16) the number of vaccine doses received (aOR: 4.8; 95%CI: 2.9; 8.0) and presenting any comorbidity (aOR: 4.3; 95%CI: 2.4; 8.0). The staff received more booster doses and obtained a better response to seropositivity, with 72.5% of anti-SARS-CoV-2 result positive while prisoners reached 56.3%.ConclusionThe COVID-19 vaccination status within the prison community following the initiation of primary immunization and subsequent booster doses, shows a low immunization coverage (60.9%), which is below expectations given the immunization strategies implemented since the start of the pandemic. There are notable differences in vaccination rates between prison staff and prisoners. These disparities are concerning, and authorities responsible for prison public health should take a more proactive approach to ensuring vaccination among prisoners.
Co-design of the neurodevelopment assessment scale
Authors: Wong Tsz Ying , Azim Syeda Ishra , Lam-Cassettari Christa , Lin Ping-I. , Mendoza Diaz Antonio , Montgomery Alicia , Masi Anne , Mallitt Kylie-Ann , Whitehouse Andrew , Dadds Mark R. , Eapen Valsamma 
Published: January 2025

IntroductionNeurodevelopmental disorders (NDDs) have high comorbidity rates and shared etiology. Nevertheless, NDD assessment is diagnosis-driven and focuses on symptom profiles of individual disorders, which hinders diagnosis and treatment. There is also no evidence-based, standardized transdiagnostic approach currently available to provide a full clinical picture of individuals with NDDs. The pressing need for transdiagnostic assessment led to the development of the Neurodevelopment Assessment Scale (NAS).MethodsThis paper describes the co-design process used in the development of NAS prototype with stakeholders including individuals with NDDs, parents of children with NDDs, and health professionals.Results and discussionResults indicated stakeholder consensus that NAS would be useful for NDD assessment, and included recommendations for fine-tuning the way some questions were asked (e.g., child's diagnoses), question flow (e.g., branching logic), and the language and presentation of the prototype (e.g., readability). Stakeholders also suggested the administration protocol should be flexible using electronic, face-to-face, online formats etc.
It's not always easy to buy the idea: strategies, perceptions, and implications of learner-centered teaching in coach education
Authors: Salles William das Neves , Martins Lincoln Cruz , Nascimento Juarez Vieira do , Milistetd Michel 
Published: January 2025

IntroductionThe study aims to investigate the development of a learner-centered teaching (LCT), a constructivist-based proposal focused on the learner and the learning process, in a university-based coach education program (CEP) through an action research (AR) approach.MethodsParticipants were six students, the researcher and the professor of a Sport Pedagogy course of a public Brazilian university. The classes were taught in a collaborative way between the professor and the researcher, and rubrics were used to guide the LCT development process.Results and discussionThe proposal was developed gradually and progressively in the course, through diversified teaching strategies that prioritized student interaction and reflection. Facilitators were constantly concerned to ensure that students' perspectives and knowledge were valued during the construction of new teaching content, contributing to align the course with the LCT perspective. While at the beginning of the course the dimensions function of content and role of the teacher were emphasized, in subsequent classes greater attention was devoted to increasing students' responsibility for learning, balance the power between facilitators and students, and promote integrated, authentic assessment processes. To advance the investigated CEP, we recommend the LCT development in other courses of the program, enabling the consolidation of a curricular culture aligned to the constructivist perspective.
Correlation between follicle diameter and pre-ovulatory metabolic profile in Bos grunniens
Authors: Yan Jiuru , Fu Yuxin , Lan Lan , Zhang Huizhu , Huang Ling , Wang Yaying , Xiong Xianrong , Yin Shi , Li Jian , He Honghong 
Published: January 2025

IntroductionIn this study, we investigated the metabolic profiles of yak (Bos grunniens) follicles during the development period from the perspective of metabolomics, aiming to screen out the differential metabolites of yak follicles in different sizes and potential pathways during yak follicle development and to provide a basis for the study of follicle development and developmental mechanisms in the further stage of development.MethodsA total of 20 four-year-old female yaks were selected, and follicles of different sizes were collected after slaughter and divided into d &lt; 3 mm, 3–6 mm and d &gt; 6 mm. The follicular fluid was collected, 6 replicates per group and subjected to LC–MS assay, combined with multidimensional and unidimensional statistical analyses to screen the differential metabolites between follicles of different sizes. Differential metabolites enriched KEGG pathways to screen the pathways that might be related to follicle development.ResultsWe found that most of the metabolites were mainly enriched in amino acid metabolism pathways, energy metabolism pathways and other pathways of cofactor synthesis, and that during the development of the small follicle to the large follicle, 2-Lysophosphatidylcholine, PC (17:0/0:0), PC (16:0/0:0), and LysoPC (18:0/0:0) were down-regulated; Dioctyl succinate, P-Coumaraldehyde, ISOPRENE, L-Isoleucine, Dioctyl succinate up-regulated.ConclusionThese results suggest that amino acid metabolism, the production of steroid hormones and their metabolites, and the metabolic activity of granulosa cells play important roles in follicle development. The results provide a theoretical basis for further exploration of follicular development in yak.
Early embryonic thermal programming and post-hatch flavonoid (Scutellaria baicalensis) supplementation enhanced immune response markers in broiler chickens
Authors: Al Amaz Sadid , Shahid Md Ahosanul Haque , Jha Rajesh , Mishra Birendra 
Published: January 2025

IntroductionGenetic selection in broiler chickens has led to increased muscle mass without comparable respiratory and cardiovascular system development, limiting the birds’ capacity to withstand high ambient temperatures and making them vulnerable to heat stress (HS). Early embryonic Thermal Manipulation (TM) has been suggested as an effective and sustainable way to mitigate the adverse effects of HS. This study investigated how these interventions influenced the immune status of broiler chickens exposed to HS.MethodsCobb 500 fertile eggs (n = 600) were incubated according to guidelines. On embryonic day (ED) 12, the eggs were split into two groups: (1) Control, kept at standard temperature until hatch day (ED 21) and (2) Thermal Manipulation (TM), exposed to 38.5°C with 55% humidity for 12 h daily from ED 12 to ED 18. After hatching, chicks were divided into (1) Control, (2) TM, (3) Control under Heat Stress (CHS), (4) TM under Heat Stress (TMHS), (5) Control with Heat Stress and Supplementation (CHSS), and (6) TM with Heat Stress and Supplementation (TMHSS). For the first 21 days, all chicks were raised under normal conditions. From day 22 to day 35, groups CHS, TMHS, CHSS, and TMHSS experienced chronic heat stress (32–33°C for 8 h daily), while the Control and TM groups remained in a thermoneutral environment (22–24°C).Results and discussionTM significantly increased (p &lt; 0.05) AvBD11, IL4, and TLR21 expression in the spleen. TM and baicalein supplementation significantly decreased (p &lt; 0.05) TLR15 expression. In the bursa, TM significantly increased (p &lt; 0.05) IL4 expression. The combination of TM with baicalein significantly increased (p &lt; 0.05) CD3 and decreased (p &lt; 0.05) TLR1 expression. Interestingly, TM alone significantly decreased (p &lt; 0.05) IFNg expression under HS condition. In the thymus, TM significantly decreased (p &lt; 0.05) IL10 and TLR15, while incorporating baicalein with TM decreased (p &lt; 0.05) AvBD6 expression.ConclusionTM improved the immune status of broiler chickens under normal conditions. When combined with baicalein, TM mitigated the negative effects of heat stress by boosting key immune-related gene expression in the spleen, bursa, and thymus.
Acoustic Emission During Rubber-like Deformation in Ni51Fe18Ga27Co4 Single Crystalline Shape Memory Alloys
Authors: Daróczi Lajos , Kamel Sarah M. , Tóth László Z. , Panchenko Elena Yu. , Chumljakov Yuri I. , Beke Dezső L. 
Published: January 2025

Acoustic emission, AE, belonging to a rubber-like deformation in a martensitic state after the stabilization aging of the stress-induced martensite (SIM aging) of Ni51Fe18Ga27Co4 single crystals in compression, were investigated. AE activity in the plateau regions of the stress–strain loop is due to a massive reorientation from the variants produced by SIM aging to the variants preferred by the compressive stress (perpendicular to the stress used in SIM aging) and vice versa. For unloading, the large AE activity just at the knee point of the stress–stain curve is attributed to the difficulty of the re-nucleation of the SIM aging-stabilized martensite variant. The amplitude, peak energy, and area of signals can be described by power-like distributions and the characteristic exponents are in good agreement with data obtained in other alloys. Power law cross-correlations between the energy, E, and amplitude, A, as well as between the area, S, and the amplitude, A, were also analyzed. It was found that the exponents are given by 3−φ as well as 2−φ, respectively, with φ≅0.7. Normalized universal temporal shapes of avalanches (i.e., the UA versus tA1−φ plots, where U is the detected voltage) for a fixed area scale very well together. The tail of the normalized temporal shape decays more slowly than the theoretical prediction, which can be attributed to an intrinsic absorption of AE signals and/or to the overlap of sub-avalanches.
Feasibility and Tolerability of Daily Microgreen Consumption in Healthy Middle-Aged/Older Adults: A Randomized, Open-Label, Controlled Crossover Trial
Authors: Lee Sylvia Y. , Michell Kiri A. , Butler Michelle M. , Smith Brayden T. , Woolf Emily K. , Holmes Sydney C. , Grabos Lauren E. , Vazquez Allegra R. , Isweiri Hanan , Bunning Marisa , Uchanski Mark E. , Rao Sangeeta , Newman Steven E. , Weir Tiffany L. , Johnson Sarah A. 
Published: January 2025

Background/Objectives: Microgreens are rich in nutrients and phytochemicals that can support healthy aging, including attenuation of cardiovascular disease risk. The nutrient and phytochemical contents of red beet (i.e., bull’s blood’ beet, Beta vulgaris) and red cabbage (Brassica oleracea var capitate) microgreens, as well as existing preclinical evidence suggest their cardioprotective effects, but the feasibility, gastrointestinal tolerability, and human health effects of daily microgreen consumption are unknown. This study aimed to evaluate the feasibility and gastrointestinal tolerability of 2 weeks of daily microgreen consumption in healthy middle-aged/older (MA/O) adults. A secondary aim was to characterize potential health effects. Methods: Healthy MA/O adults (initial n = 26) were randomized to consume either 2 cups of ‘bull’s blood’ beet or red cabbage microgreens daily for 2 weeks in a crossover design, with each treatment period separated by 2 weeks. Feasibility was determined through participant retention and intervention compliance (i.e., total doses consumed divided by 14 days), while gastrointestinal tolerability was determined by a gastrointestinal health questionnaire and bowel movement log. Impacts of microgreen consumption on brachial and aortic hemodynamic parameters, and gut microbiota composition were evaluated. Results: Daily consumption for 2 weeks of ‘bull’s blood’ beet and red cabbage microgreens was found to be feasible as indicated by high participant retention (final n = 24) and overall treatment compliance of 95.6%. Gastrointestinal symptom severity was not impacted overall, though an improvement in gastrointestinal inflammation-associated symptom severity scores following the red cabbage microgreen intervention (p = 0.047) was observed. There were no changes in bowel movement quality, hemodynamic parameters, or on alpha or beta diversity of the gut microbiota. Conclusions: Daily consumption of ‘bull’s blood’ beet and red cabbage microgreens is feasible and tolerable in healthy MA/O adults. Future studies designed to evaluate their health impacts are needed.
PULSE: A Fast Portable Unit for Lab-on-Site Electrochemistry
Authors: Ferreira Cláudia , Barry Fiona , Todorović Miomir , Sugrue Patrick , Teixeira Sofia Rodrigues , Galvin Paul 
Published: January 2025

This study aims to develop and validate a novel fast-detection electrochemical sensing platform to enhance portable electrochemical sensor solutions. The research focuses on optimising analogue front-end circuits, developing data analysis algorithms, and validating the device through experiments to enhance measurement accuracy and detection speed, enabling on-site measurements across diverse applications. This work successfully designed a Portable Unit for Lab-on-Site Electrochemistry (PULSE) system with dimensions of (78×100×2) mm3. The device’s implementation was complemented by robust firmware that performed desired electrochemical measurements, including open circuit potentiometry (OCP), chronoamperometry (CA), and cyclic voltammetry (CV). To assess its reliability, the PULSE was benchmarked against a well-established benchtop potentiostat. The results obtained highlight the system’s rapid sensing capabilities, achieving pH detection in 2 s and performing CA in 20 s. The pH calibration curve exhibited Nernstian behaviour with an accuracy of 97.58%. A correlation analysis comparing the calibration curve datasets across all electrochemical techniques from both systems revealed high correlation coefficients (>0.99), confirming the strong agreement between the two systems.
Immunoprotection Provided by Salivary and Intestinal Protein-Based Antigens Against the Ixodid Tick Amblyomma sculptum
Authors: Natividade Ulisses A. , Abreu Jessica F. , Ribeiro Izabela C. T. , Pereira Filho Adalberto A. , Silva Augusto V. , Ribeiro Helen S. , Giunchetti Rodolfo C. , Sant’Anna Mauricio R. V. , Gontijo Nelder F. , Pereira Marcos H. , Araujo Ricardo N. 
Published: January 2025

Background/Objectives: Amblyomma sculptum is among the most dangerous ticks in South America, as it is the species most associated with humans and is the main vector of Rickettsia rickettsii. In the face of the problems related to tick control based on chemical acaricides, vaccines emerge as a promising method. In previous works, three salivary recombinant proteins (rAs8.9kDa, rAsKunitz, and rAsBasicTail) and one protein based on intestinal immunogenic regions (rAsChimera) were described with 59 to 92% vaccine efficacy against A. sculptum females. Here, we evaluate novel vaccine formulations containing binary or multiple combinations of the antigens rAs8.9kDa, rAsKunitz, rAsBasicTail, and rAsChimera against the three instars of the tick. Methods: A control group of mice was immunized with adjuvant alone (aluminum hydroxide gel) and compared to five groups immunized with formulations containing two, three, or four of the antigens. Results: The formulations were safe, with no significant alterations to host behavior and hematological or biochemical parameters. Immunizations induced a significant increase in the CD19+ B lymphocyte percentage in all groups, but no difference was seen for CD8+ and CD4+ T lymphocytes or CD14+ monocytes. The best protection was observed for the formulations containing two antigens, which reached above 98% efficacy, while the groups containing three or four antigens presented 92.7 and 94.4% efficacy, respectively. Conclusions: All antigen combinations were promising as vaccine formulations against A. sculptum. The formulation containing rAs8.9kDa and rAsChimera showed the best efficacy and should be focused on in further experiments.
Beds and Bed Pavilions in Java before 1500 CE
Authors: Jákl Jiří 
Published: January 2025

This article focuses on furniture, and more specifically beds and bed pavilions in pre-Islamic Java, hence before 1500 CE . In this way, it intends to contribute to the knowledge of an aspect of Javanese material culture that is still in need of comprehensive studies. Old Javanese and Malay texts read against the iconographic evidence on temple stone reliefs and metalware identify four types of “sleeping apparatus” in pre-Islamic Java: a mat unrolled on the floor; a wooden or bamboo bed-platform, standing on four or more legs, which were supported on stone or terracotta bases (umpaks); a movable bed consisting of a bedstead standing on wooden legs (what one might be tempted to call a “true” bed); and a canopy bed, which probably developed from the curtained bedchamber. The article also considers the elements that complete the beds’ functional equipment, such as mattress padding and curtains that ensure privacy for their users. Even in their terse form, the different sources can be used to develop hypotheses on the association of some of these beds with groups of people identified by social rank or gender, and on the influence of foreign furniture on the design of beds in Java. Finally, this study also seeks to determine the precise meaning of various Javanese terms used to designate items of furniture intended for rest or pleasure, as tilām/tilam, </i>palaṅka</i>, and jinǝm.
Eksistensi Perkawinan Sirri Setelah Keluarnya Putusan Mahkamah Konstitusi No. 46/PUU-VIII/2010
Authors: Kusumo Bambang Ali , Supriyanta Supriyanta 
Published: January 2025

<p>Dalam wacana Hukum Perkawinan, Perkawinan Sirri masih terjadi perdebatan baik dari masyarakat maupun dari pihak pemerintah. Termasuk perkawinan Sirri yang dilakukan oleh Hj. Macicha Moehtar dengan Murdiono pada Tahun 1993. Pihak Macicha Moehtar mengajukan Yudicial Review ke Mahkamah Konstitusi untuk menyelesaikan kasus yang dialaminya. Selanjutnya Mahkamah Konstitusi mengeluarkan Putusan Nomor 46/PUU-VIII/2010 yang isinya mengesahkan perkawinan sirri yang dilakukan oleh Hj. Aisyah Muhtar dengan Murdiono dan menyatakan bahwa anak luar nikah hasil perkawinan sirri tersebut mempunyai hubungan perdata dengan ibu dan bapaknya. Namun dalam Putusan Mahkamah Konstitusi tersebut menambahkan anak luar nikah hasil perzinaan, perselingkuhan dan samen leven selain juga mempunyai hubungan perdata dengan ibunya dan keluarganya juga mempunyai hubungan perdata dengan ayahnya dan keluarga ayahnya sepanjang dapat dibuktikan berdasarkan ilmu pengetahuan dan teknologi dan/atau alat bukti lain menurut hukum ternyata mempunyai hubungan darah. Yang menjadi kontroversi adalah anak luar nikah hasil zina, perselingkuhan dan samen leven mempunyai hubungan perdata dengan ibu dan bapaknya. Penelitian ini merupakan penelitian yuridis normatif yang data utamanya adalah data sekundair, yang terdiri dari bahan hukum primer, bahan hukum sekundair dan bahan hukum tersier. Analisis data dilakukan dengan diskriptif kualitatif. Hasil penelitian menunjukkan bahwa perkawinan sirri berdasarkan Putusan Mahkamah Konstitusi No. 46/PUU-VIII/2010 merupakan perkawinan yang sah dan lahirnya anak dari perkawinan itu merupakan tanggung jawab dari ibunya dan bapaknya. Dengan adanya putusan Mahkamah Konstitusi tersebut, maka perkawinan Sirri selanjutnya dinyatakan sah dan anak yang lahir dari perkawinan tersebut merupakan tanggung jawab dari ibu dan bapaknya.</p>