bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Leftward Biased Cold Wakes Induced by Tropical Cyclones in the North Hemisphere
Authors: Ye Hexin , Ma Zhanhong , Fei Jianfang , Duan Yihong 
Published: December 2023

AbstractThe cold wake features are one of the most significant characteristics left behind by tropical cyclones (TCs) over the warm ocean. In the past several decades, the cold wakes have been widely conceived to be rightward biased (in the Northern Hemisphere). This basic cognition is examined in this study based on satellite sea surface temperature (SST) data with the high‐resolution of ∼0.09° between 2002 and 2021. Statistical results reveal that roughly one third (∼30.58%) of TC cold wakes are actually leftward biased in real world. On average, the maximum cooling of leftward cold wakes is approximately −0.7°C, appearing at ∼60 km to the left of the storm track. The proportion of leftward cases decreases steadily with increasing TC intensity, while shows little relation with the translation speed. The leftward biased phenomena are found to be independent from meso‐scale oceanic features and mainly attributed to inhomogeneous large‐scale background oceanic environment. The generally deeper (shallower) pre‐storm mixed layer and weaker (stronger) stratification found in the right (left) of track can effectively suppress rightward (enhance leftward) surface cooling and synchronously deform the normal spatial patterns of cold wakes. These effects cooperate with leftward‐biased surface enthalpy flux resulted from asymmetric pre‐storm SST, and eventually contributes to the left‐shifted feature. A series of three‐dimensional simulations using the three‐dimensional Price‐Weller‐Pinkel (3DPWP) model consolidate these physical explanations. Further observations suggest that distributions of cold wakes could significantly affect the asymmetric precipitation of TCs, confirming the importance of leftward cases to the TCs structure.
Enhanced Turbulent Diapycnal Mixing in the Northern Sargasso Sea Inferred From a Finescale Parameterization
Authors: Li Zhuoran , Jing Zhao , Wu Lixin , Johnson Rodney J. , Yang Zhibin , Song Zhuo , Chen Zhaohui , Gan Bolan , Ma Xiaohui 
Published: December 2023

AbstractThe Sargasso Sea, accommodating marine species and mode water, is highly productive relative to other oligotrophic subtropical regions with intense air‐sea carbon and heat exchanges. Turbulent diapycnal mixing regulates these processes and is generally thought to be weakened in a more stratified ocean under anthropogenic forcing. However, by applying a finescale parameterization to long‐term hydrographic profiles collected during the Bermuda Atlantic Time‐Series Study (BATS), we show that its intensity has become stronger from 1994 to 2019 in the permanent thermocline. The enhanced turbulent diapycnal mixing is mainly attributed to the increase of wind power on internal waves along the Gulf Stream extension. Numerical simulations suggest that stronger internal waves excited along the Gulf Stream extension radiate downward and equatorward, causing enhanced turbulent diapycnal mixing in the northern Sargasso Sea including the BATS station. The findings have important implications for understanding responses of mode water and ecosystem in the Sargasso Sea to anthropogenic forcing.
Scale‐Awareness in an Eddy Energy Constrained Mesoscale Eddy Parameterization
Authors: Mak J. , Maddison J. R. , Marshall D. P. , Ruan X. , Wang Y. , Yeow L. 
Published: December 2023

AbstractThere is an increasing interest in mesoscale eddy parameterizations that are scale‐aware, normally interpreted to mean that a parameterization does not require parameter recalibration as the model resolution changes. Here we examine whether Gent–McWilliams (GM) based version of GEOMETRIC, a mesoscale eddy parameterization that is constrained by a parameterized eddy energy budget, is scale‐aware in its energetics. It is generally known that GM‐based schemes severely damp out explicit eddies, so the parameterized component would be expected to dominate across resolutions, and we might expect a negative answer to the question of energetic scale‐awareness. A consideration of why GM‐based schemes damp out explicit eddies leads a suggestion for what we term a splitting procedure: a definition of a “large‐scale” field is sought, and the eddy‐induced velocity from the GM‐scheme is computed from and acts only on the large‐scale field, allowing explicit and parameterized components to co‐exist. Within the context of an idealized re‐entrant channel model of the Southern Ocean, evidence is provided that the GM‐based version of GEOMETRIC is scale‐aware in the energetics as long as we employ a splitting procedure. The splitting procedure also leads to an improved representation of mean states without detrimental effects on the explicit eddy motions.
Modeling Pipe to Soil Potentials From Geomagnetic Storms in Gas Pipelines in New Zealand
Authors: Divett Tim , Ingham Malcolm , Richardson Gemma , Sigley Mark , Rodger Craig J. 
Published: December 2023

AbstractGas pipelines can experience elevated pipe to soil potentials (PSPs) during geomagnetic disturbances due to the induced geoelectric field. Gas pipeline operators use cathodic protection to keep PSPs between −0.85 and −1.2 V to prevent corrosion of the steel pipes and disbondment of the protective coating from the pipes. We have developed a model of the gas pipelines in the North Island of New Zealand to identify whether a hazard exists to these pipelines and how big this hazard is. We used a transmission line representation to model the pipelines and a nodal admittance matrix method to calculate the PSPs at nodes up to 5 km apart along the pipelines. We used this model to calculate PSPs resulting from an idealized 100 mVkm−1 electric field, initially to the north and east. The calculated PSPs are highest are at the ends of the pipelines in the direction of the applied electric field vector. The calculated PSP follows a characteristic curve along the length of the pipelines that matches theory, with deviations due to branchlines and changes in pipeline direction. The modeling shows that the PSP magnitudes are sensitive to the branchline coating conductance with higher coating conductances decreasing the PSPs at most locations. Enhanced PSPs produce the highest risk of disbondment and corrosion occurring, and hence this modeling provides insights into the network locations most at risk.
Contrasting Land and Atmospheric Controls on the Generalized Complementary Relationship of Evaporation Over Grasslands and Forests
Authors: Han Songjun , Yan Jianwei , Liu Yaping , Tian Fuqiang , Zhang Baozhong , Wang Xiaochun , Shao Changliang , Wang Liming 
Published: December 2023

AbstractThe generalized complementary relationship (CR) rooted on land–atmosphere coupling has been widely used to study evaporation over various ecosystems. Evaporation estimation models based on CR usually contain two parameters. The first one controls the shape of CR, and the second one is related to potential evaporation (Epo). Previous studies have found substantial variations in these parameters, but how they are affected by land surface and/or the atmosphere under conditions with varying land–atmosphere coupling remains unclear. In this study, the land and atmospheric controls for the generalized CR were comparatively investigated focusing on the two parameters of the sigmoid type function by using the data of 24 grassland and 19 forest flux sites and by considering the contrasting land–atmosphere coupling strength. The strong coupling to the outer atmosphere at the forest sites resulted in a large variation in the Epo‐related parameter and its significant correlation with the mean relative humidity. The shape parameter had a large variation at the grassland sites due to the weak coupling with the outer atmosphere and was significantly correlated with the mean soil water content. The simple parameterizations for the two parameters based on the correlations improved the predictions of monthly actual evaporation compared with the parameterizations for the fixed parameters corresponding to ecosystem types. The effects of land surface wetness and local advections on the generalized CR over grasslands and forests were also discussed respectively.
Development and validation of a machine learning model using electronic health records to predict trauma- and stressor-related psychiatric disorders after hospitalization with sepsis
Authors: Papini Santiago , Iturralde Esti , Lu Yun , Greene John D. , Barreda Fernando , Sterling Stacy A. , Liu Vincent X. 
Published: December 2023

AbstractA significant minority of individuals develop trauma- and stressor-related disorders (TSRD) after surviving sepsis, a life-threatening immune response to infections. Accurate prediction of risk for TSRD can facilitate targeted early intervention strategies, but many existing models rely on research measures that are impractical to incorporate to standard emergency department workflows. To increase the feasibility of implementation, we developed models that predict TSRD in the year after survival from sepsis using only electronic health records from the hospitalization (n = 217,122 hospitalizations from 2012-2015). The optimal model was evaluated in a temporally independent prospective test sample (n = 128,783 hospitalizations from 2016-2017), where patients in the highest-risk decile accounted for nearly one-third of TSRD cases. Our approach demonstrates that risk for TSRD after sepsis can be stratified without additional assessment burden on clinicians and patients, which increases the likelihood of model implementation in hospital settings.
Position-sensitive non-destructive detection of charged-particle bunches in low-energy beamlines
Authors: Ringleb Stefan , Kiffer Markus , Ballentin Jonas K. C. , Stöhlker Thomas , Vogel Manuel 
Published: December 2023

AbstractWe have developed and operated an electronic detection system for the non-destructive single-pass detection of bunches of charged particles in a beamline that allows for a measurement of their lateral position with respect to the central beamline axis on a shot-to-shot basis. It provides all features of our related development reported in Kiffer et al. (Rev Sci Instrum 90:113301, 2019), namely single-pass measurement of bunch length, kinetic energy and absolute charge, and is additionally designed to provide the lateral position of bunches with sub-mm accuracy. We show the setup, associated methods and provide characterizing measurements with bunches of highly charged ions in the keV regime of kinetic energy that demonstrate the capabilities and show a typical application.
Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace
Authors: Rafaqat Saira , Sharif Saima , Majeed Mona , Naz Shagufta , Saqib Muhammad , Manzoor Farkhanda 
Published: December 2023

AbstractAdiponectin, an adipocytokine produced and secreted by adipose tissue, has anti-diabetic, anti-atherogenic, and anti-inflammatory properties. This case-control study was aimed to assess the expression and serum levels of adiponectin in subject suffereing from atrial fibrillation (AF). The study's subjects (n = 690) were enrolled from the Punjab Institute of Cardiology, Lahore and were grouped into control, AF without Metabolic syndrome (MetS), and AF with MetS groups. Along with the collection of demographic data, an analysis of adiponectin and biochemical parameters were performed. A highly significant difference in serum levels of adiponectin was observed among the control, AF without MetS, and AF with MetS groups (61.61 ± 45.30 ng/ml, 37.20 ± 19.46 ng/ml, 63.78 ± 61.69 ng/ml). The expression analysis of adiponectin was decreased (n-fold = ̴ 0.30) in AF without MetS group as compared to control group (n-fold =  ~ 1.16) but increased in AF with MetS group (n-fold = ̴ 6.26). The correlation analysis revealed a highly significant positive relationship between the expression of the adiponectin gene with waist-to-hip ratio (WHR) in AF without MetS group. Whereas, serum adiponectin was negatively related to serum triglycerides (TG) in AF with MetS group. In multiple regression analysis using adiponectin expression as the dependent variable, WHR was a determinant in AF without MetS. Whereas, when serum adiponectin was used as the dependent variable, serum TG was the determinant in group AF with MetS. The present study implicates that decreased expression and serum levels of adiponectin were associated with the development of AF in which WHR and serum TG also contributed towards the onset of atrial fibrillation.
Global trends in antimicrobial resistance on organic and conventional farms
Authors: Ager Eldon O. , Carvalho Tamilie , Silva Erin M. , Ricke Steven C. , Hite Jessica L. 
Published: December 2023

AbstractThe important hypothesis that organic livestock management reduces the prevalence of antimicrobial resistance is either fiercely supported or bitterly contested. Yet, empirical evidence supporting this view remains fragmentary, in part because relationships between antimicrobial use and drug resistance vary dramatically across contexts, hosts, pathogens, and country-specific regulations. Here, we synthesize global policies and definitions of ‘organic’ and ask if organic farming results in notable reductions in the prevalence of antimicrobial resistance when directly examined alongside conventional analogs. We synthesized the results of 72 studies, spanning 22 countries and five pathogens. Our results highlight substantial variations in country-specific policies on drug use and definitions of ‘organic’ that hinder broad-scale and generalizable patterns. Overall, conventional farms had slightly higher levels of antimicrobial resistance (28%) relative to organic counterparts (18%), although we found significant context-dependent variation in this pattern. Notably, environmental samples from organic and conventional farms often exhibited high levels of resistance to medically important drugs, underscoring the need for more stringent and consistent policies to control antimicrobial contaminants in the soil (particularly on organic farms, where the application of conventional manure could faciliate the spread antimicrobial resistance). Taken together, these results emphasize the challenges inherent in understanding links between drug use and drug resistance, the critical need for global standards governing organic policies, and greater investment in viable alternatives for managing disease in livestock.
Flow-induced oscillations of vocal-fold replicas with tuned extensibility and material properties
Authors: Luizard Paul , Bailly Lucie , Yousefi-Mashouf Hamid , Girault Raphaël , Orgéas Laurent , Henrich Bernardoni Nathalie 
Published: December 2023

AbstractHuman vocal folds are highly deformable non-linear oscillators. During phonation, they stretch up to 50% under the complex action of laryngeal muscles. Exploring the fluid/structure/acoustic interactions on a human-scale replica to study the role of the laryngeal muscles remains a challenge. For that purpose, we designed a novel in vitro testbed to control vocal-folds pre-phonatory deformation. The testbed was used to study the vibration and the sound production of vocal-fold replicas made of (i) silicone elastomers commonly used in voice research and (ii) a gelatin-based hydrogel we recently optimized to approximate the mechanics of vocal folds during finite strains under tension, compression and shear loadings. The geometrical and mechanical parameters measured during the experiments emphasized the effect of the vocal-fold material and pre-stretch on the vibration patterns and sounds. In particular, increasing the material stiffness increases glottal flow resistance, subglottal pressure required to sustain oscillations and vibratory fundamental frequency. In addition, although the hydrogel vocal folds only oscillate at low frequencies (close to 60 Hz), the subglottal pressure they require for that purpose is realistic (within the range 0.5–2 kPa), as well as their glottal opening and contact during a vibration cycle. The results also evidence the effect of adhesion forces on vibration and sound production.
Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells
Authors: Islam Kittiya , Balasubramanian Brinda , Venkatraman Simran , Thummarati Parichut , Tunganuntarat Janpen , Phueakphud Nut , Kanjanasirirat Phongthon , Khumpanied Tanawadee , Kongpracha Pornparn , Kittirat Yingpinyapat , Tohtong Rutaiwan , Janvilisri Tavan , Wongtrakoongate Patompon , Borwornpinyo Suparerk , Namwat Nisana , Suthiphongchai Tuangporn 
Published: December 2023

AbstractA poor outcome for cholangiocarcinoma (CCA) patients is still a clinical challenge. CCA is typically recognized by the desmoplastic nature, which accounts for its malignancy. Among various extracellular matrix proteins, laminin is the most potent inducer for CCA migration. Herein, we accessed the expression profiles of laminin gene family and explored the significance of the key laminin subunit on CCA aggressiveness. Of all 11 laminin genes, LAMA3, LAMA5, LAMB3 and LAMC2 were concordantly upregulated based on the analysis of multiple public transcriptomic datasets and also overexpressed in Thai CCA cell lines and patient tissues in which LAMA3A upregulated in the highest frequency (97%) of the cases. Differential expression genes (DEGs) analysis of low and high laminin signature groups revealed LAMA3 as the sole common DEG in all investigated datasets. Restratifying CCA samples according to LAMA3 expression indicated the association of LAMA3 in the focal adhesion pathway. Silencing LAMA3 revealed that it plays important roles in CCA cell proliferation, adhesion, migration and epithelial-to-mesenchymal transition. Taken together, this research signifies the roles of dysregulated ECM homeostasis in CCA malignancy and highlights, for the first time, the potential usage of LAMA3 as the diagnostic biomarker and the therapeutic target to tackle the CCA stromal.
Task-evoked pulse wave amplitude tracks cognitive load
Authors: Pavlov Yuri G. , Gashkova Anastasia S. , Kasanov Dauren , Kosachenko Alexandra I. , Kotyusov Alexander I. , Kotchoubey Boris 
Published: December 2023

AbstractCognitive load is a crucial factor in mentally demanding activities and holds significance across various research fields. This study aimed to investigate the effectiveness of pulse wave amplitude (PWA) as a measure for tracking cognitive load and associated mental effort in comparison to heart rate (HR) during a digit span task. The data from 78 participants were included in the analyses. Participants performed a memory task in which they were asked to memorize sequences of 5, 9, or 13 digits, and a control task where they passively listened to the sequences. PWA and HR were quantified from photoplethysmography (PPG) and electrocardiography (ECG), respectively. Pupil dilation was also assessed as a measure of cognitive load. We found that PWA showed a strong suppression with increasing memory load, indicating sensitivity to cognitive load. In contrast, HR did not show significant changes with task difficulty. Moreover, when memory load exceeded the capacity of working memory, a reversal of the PWA pattern was observed, indicating cognitive overload. In this respect, changes in PWA in response to cognitive load correlated with the dynamics of pupil dilation, suggesting a potential shared underlying mechanism. Additionally, both HR and PWA demonstrated a relationship with behavioral performance, with higher task-evoked HR and lower PWA associated with better memory performance. Our findings suggest that PWA is a more sensitive measure than HR for tracking cognitive load and overload. PWA, measured through PPG, holds significant potential for practical applications in assessing cognitive load due to its ease of use and sensitivity to cognitive overload. The findings contribute to the understanding of psychophysiological indicators of cognitive load and offer insights into the use of PWA as a non-invasive measure in various contexts.
Multitechnique characterization of secondary minerals near HI-SEAS, Hawaii, as Martian subsurface analogues
Authors: Mulder Sebastian J. , van Ruitenbeek Frank J. A. , Foing Bernard H. , Sánchez-Román Mónica 
Published: December 2023

AbstractSecondary minerals in lava tubes on Earth provide valuable insight into subsurface processes and the preservation of biosignatures on Mars. Inside lava tubes near the Hawaii-Space Exploration and Analog Simulation (HI-SEAS) habitat on the northeast flank of Mauna Loa, Hawaii, a variety of secondary deposits with distinct morphologies were observed consisting of mainly sodium sulphate powders, gypsum crystalline crusts, and small coralloid speleothems that comprise opal and calcite layers. These secondary deposits formed as a result of hydrological processes shortly after the formation and cooling of the lava tubes and are preserved over long periods of time in relatively dry conditions. The coralloid speleothem layers are likely related to wet and dry periods in which opal and calcite precipitates in cycles. Potential biosignatures seem to have been preserved in the form of porous stromatolite-like layers within the coralloid speleothems. Similar secondary deposits and lava tubes have been observed abundantly on the Martian surface suggesting similar formation mechanisms compared to this study. The origin of secondary minerals from tholeiitic basalts together with potential evidence for microbial processes make the lava tubes near HI-SEAS a relevant analog for Martian surface and subsurface environments.
LPS and its relationship with subjective–objective discrepancies of sleep onset latency in patients with psychiatric disorders
Authors: Kawai Keita , Iwamoto Kunihiro , Miyata Seiko , Okada Ippei , Ando Motoo , Fujishiro Hiroshige , Ando Masahiko , Noda Akiko , Ozaki Norio 
Published: December 2023

AbstractSubjective–objective discrepancies in sleep onset latency (SOL), which is often observed among psychiatric patients, is attributed partly to the definition of sleep onset. Recently, instead of SOL, latency to persistent sleep (LPS), which is defined as the duration from turning out the light to the first consecutive minutes of non-wakefulness, has been utilized in pharmacological studies. This study aimed to determine the non-awake time in LPS that is most consistent with subjective sleep onset among patients with psychiatric disorders. We calculated the length of non-awake time in 30-s segments from lights-out to 0.5–60 min. The root mean square error was then calculated to determine the most appropriate length. The analysis of 149 patients with psychiatric disorders showed that the optimal non-awake time in LPS was 12 min. On the other hands, when comorbid with moderate or severe obstructive sleep apnea (OSA), the optimal length was 19.5 min. This study indicates that 12 min should be the best fit for the LPS non-awake time in patients with psychiatric disorders. When there is comorbidity with OSA, however, a longer duration should be considered. Measuring LPS minimizes discrepancies in SOL and provides important clinical information.