bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population
Authors: Shirai Toshiyuki , Okazaki Satoshi , Tanifuji Takaki , Otsuka Ikuo , Miyachi Masao , Okada Shohei , Shindo Ryota , Horai Tadasu , Mouri Kentaro , Takahashi Motonori , Kondo Takeshi , Ueno Yasuhiro , Hishimoto Akitoyo 
Published: January 2024

AbstractBackgroundMore than 800 000 people die by suicide annually. The heritability of suicide is 30%–50%. We focused on the hypoxia response element (HRE), which promotes the expression of macrophage migration inhibitory factor (MIF) via the hypoxia‐inducible factor (HIF) pathway, important in neurogenesis and neuroprotection. We examined a genetic polymorphism of rs17004038, a single‐nucleotide polymorphism (SNP), in suicide completers and controls.MethodsThe study population included 1336 suicide completers and 814 unrelated healthy controls. All participants were Japanese. We obtained peripheral blood, extracted DNA, and genotyped the patients for SNP rs17004038 (C > A).ResultsNo significant differences were observed between the two groups in either the allele or genotype analyses. Subgroup analyses by sex, age (<40 or ≥40), and suicide method (violent or nonviolent suicide) were performed with similar results.ConclusionNo association was observed between SNP rs17004038 and suicide completion. Although it is challenging to collect a large number of samples from suicide completers, further MIF‐related genetic studies, including those of rs17004038, are necessary with larger sample sizes.
Safety and tolerability of intravenous aprepitant and fosaprepitant in children with cancer: A retrospective, single‐center review
Authors: Kanukollu Srivarshini , Spatz Krisoula , Lavery Jessica A. , Bender Julia Glade , Mauguen Audrey , Mathew Sherry 
Published: January 2024

AbstractNK‐1 receptor antagonists (NK1‐RA) are key agents for chemotherapy‐induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy. Current pediatric practice guidelines recommend the use of intravenous fosaprepitant or oral aprepitant. However, there are reports of hypersensitivity reactions with fosaprepitant due to polysorbate 80. Intravenous aprepitant does not contain polysorbate 80, but its use in pediatric patients has not been described. In this retrospective, single‐center study, 106 pediatric patients received either fosaprepitant or intravenous aprepitant as part of their antiemetic regimen. Intravenous aprepitant was well tolerated and did not lead to any instances of hypersensitivity reactions requiring discontinuation.
Handheld lidar as a tool for characterizing wood‐rich river corridors
Authors: Marshall Anna , Morrison Ryan R. , Jones Brady , Triantafillou Shayla , Wohl Ellen 
Published: January 2024

AbstractWood accumulations influence geomorphic, hydraulic, and ecologic functions within a river corridor, but characterizing these accumulations presents challenges across a range of field and remote sensing methodologies. We evaluate the ability of handheld lidar scanners, specifically lidar‐scanning capabilities of a fourth‐generation iPad Pro, to collect three‐dimensional wood accumulation data, which can be used to inform measurements of wood volume, porosity, complexity, and roughness. We discuss the potential and limitations of this novel methodology for river research and management. We found that handheld lidar presents a cost‐effective input for data‐processing workflows that field measurements of wood accumulation dimensions cannot as easily replicate including (1) a user‐friendly means of data collection and visualization; (2) accurate comparisons of wood volume over time; (3) integration into workflows to measure porosity parameters; and (4) potential use in informing hydraulic and morphodynamic models. Consideration of study area constraints and intended use of scans are prerequisites to using handheld lidar as an effective tool. We identified some specific limitations of using handheld lidar scanners in wood‐rich river corridors, including (1) scanners perform poorly when wood is under water or surrounded by dense vegetation; (2) scanners require physical access to areas of interest at distances less than 5 m; (3) scans need to be manually georeferenced; and (4) scans require manual measurements for any dimensional data, which still have associated user time and error. Handheld lidar as a scientific tool is rapidly developing and there is substantial room for expansion of applications, utilization, and advances in the use of this tool in river research and management.
Fluorinated 1,2,3‐Triazoles: Terra Incognita in 1,2,3‐Triazoles Chemistry
Authors: Pokhodylo Nazariy , Levchenko Kostiantyn , Obushak Mykola 
Published: January 2024

AbstractThis review is devoted to the synthesis and application of fluoro‐substituted 1,2,3‐triazoles. The analysis of the available studies of fluorinated triazoles indicates exceptional value properties especially for biomedical research, despite the significant limitations of synthetic methods of their preparation. In general, it can be noted that today there are only two strategic approaches to obtaining fluorinated triazoles. First, Huisgen 1,3‐dipolar cycloaddition, which is significantly limited by stability problems of fluorine‐unsaturated dipolarophiles, regioselectivity and low conversion problems. This approach allows preferentially obtaining 4‐fluoro‐1‐substituted triazoles. Second, nucleophilic substitution, which allows obtaining 5‐fluoro‐1,4‐disubstitution, but under rather hard conditions and is also limited by the nature of the substituent. Finally, there are practically no protocols for the preparation difluorotriazoles, and, also, the use of fluoro‐substituted 1,2,3‐triazoles as regents for further transformations is not enough studied.
Fluorescent Carbon Dots from Bamboo Stem Waste: Synthesis, Characterization, and Inkjet Printing
Authors: V Bavya , Pillai Adarsh Sivan , Surendran Kuzhichalil Peethambharan , T.P.D. Rajan , K.I. Suresh 
Published: January 2024

AbstractAmong the various anti‐counterfeiting solutions, fluorescent compounds gained attention as challenging to copy solutions because of astute technological improvements. However, fluorescent compound usage in counterfeit detection is limited due to high price of rare earth metals, the low photostability of pigments or organic dyes, and the long‐term toxicity of conventional semiconductor quantum dots. Herein lies the value of carbon dot, a very stable, reasonably priced, and environmentally friendly material with intriguing features. In this work the development of blue fluorescent, N‐doped carbon dots (NCD) from waste bamboo stem cuttings via hydrothermal route is presented as an environmentally friendly approach to reduce the risk of toxic gas evolution from burning of bamboo waste. The carbon dot's practical application in anti‐counterfeit printing was ascertained by comprehending it's superior properties, such as high water solubility, eco‐friendliness, dazzling fluorescence, and surface functionalization through various characterization techniques. Inkjet printing of the designs on paper substrate using the aqueous NCD ink displayed reversible encryption‐decryption ability through variation of pH. The development paves the way for value‐added utilization of waste bamboo cuttings in fluorescent ink production.
Design, Synthesis, in vitro Anti‐inflammatory Activity and in silico Studies of Imidazole‐Based 1,2,3‐Triazole Hybrids Targeting p38 MAP Kinase
Authors: Awasthi Archana , Azizur Rahman Md. , Pingili. Divya , Raju M. Bhagavan 
Published: January 2024

Abstractp38 MAP kinases are involved in numerous inflammatory diseases. A series of 14 molecules of 1,2,3 triazole linked 4‐((2‐cyclohexyl‐4,5‐diphenyl‐1H‐imidazol‐1‐yl) methyl)‐1‐phenyl hybrids(7 a–7 n) has been synthesized by click reaction. Spectral data characterized all the synthesized compounds. The final compounds were screened for in vitro p38 MAP kinase inhibitory activity. Three compounds from the series 7 c, 7 f, and 7 n expounded superior activity with IC50 values 234.08±19.65 nM, 222.68±20.69 nM, and 241.70±20.51 nM respectively while two compounds (7 d and 7 e) showed considerable activity compared to prototype drug Adezmapimod (SB203580) (IC50 value 257.13±23.94 nM). The docking study of synthesized molecules revealed that the three compounds (7 f,7 g, and 7 n) showed higher binding affinities than Adezmapimod. The “Desmond v3.6 Program” was utilized to conduct MD simulations. The result revealed that compound 7 f was conformationally stable. The ADME studies were performed using the Swiss ADME algorithm. Studies revealed that all the compound‘s defiance of Lipinski's rule is within acceptable ranges with few violations. Compound 7 f was orally active and showed good gastrointestinal absorption within the acceptable range. The search for newer compounds with increased activity compared to Adezmapimod resulted in identifying a novel subclass of p38 MAP kinase inhibitors.
Synthesis and cooperative guest binding of tetrameric porphyrin macrocycle
Authors: Tanabe Kouta , Hisano Naoyuki , Haino Takeharu 
Published: January 2024

AbstractA new family of macrocyclic host molecules that possess two bisporphyrin clefts was synthesized. The tetrameric porphyrin macrocycle provides the two guest binding sites in which two electron‐deficient aromatic molecules are encapsulated through donor‐acceptor and π‐π stacking interactions. The tetrameric porphyrin macrocycle showed positive cooperativity, whereas the nonmacrocyclic analog did not. The preorganization concept drives positive cooperativity, which is directed by the entropy benefit to macrocyclization.
Suppressed Droplet Splashing on Positively Skewed Surfaces for High‐Efficiency Evaporation Cooling
Authors: Wang Zhaochang , Liu Xiaojun , Ji Jiawei , Guo Yuhang , Zhu Yongqing , Zhang Guotao , Tong Baohong , Jiao Yunlong , Liu Kun 
Published: January 2024

AbstractTwo types of functional surfaces with the same roughness but completely different surface topographies are prepared, namely positively skewed surfaces filled with micropillar arrays (Sa ≈4.4 µm, Ssk >0) and negatively skewed surfaces filled with microcavity arrays (Sa ≈4.4 µm, Ssk <0), demonstrating promoting droplet splashing. Remarkably, the critical Weber number for generating satellite droplets on the negatively skewed surfaces is significantly lower than that on the positively skewed surfaces, indicating that the negatively skewed surface with microcavity arrays is more likely to promote droplet splashing. It is mainly attributed to the fact that air on the negatively skewed surface can make the liquid film take on a Cassie‐Baxter state on the surface so that the stabilizing capillary force of the liquid film exceeds the destabilizing stress of the air film. Moreover, the surface topography promoting droplet spreading and the mechanical properties of three‐phase moving contact lines are analyzed from the perspective of microscopic interface mechanics. Finally, it is demonstrated the designed positively skewed surfaces can be employed for large‐area heat dissipation by means of high‐efficiency evaporation.
Biocompatible Polysaccharide‐Based Wound Dressing Comprising Cellulose Fabric Treated with Gum Tragacanth, Alginate, Bacterial Cellulose, and Chamomile Extracts
Authors: Tohidi Azadeh , Montazer Majid , Mianehro Ali , Rad Mahnaz Mahmoudi 
Published: January 2024

AbstractMedical fabrics and gauze are some of the most utilized functional fabrics. In this study, an appropriate wound dressing for quick wound healing is produced utilizing natural materials that are compatible with human skin. Because of its biodegradability, biocompatibility, and nontoxic characteristics, gum tragacanth demonstrates a wide range of applications in a variety of sectors, including healthcare, pharmaceutical, and other fields. Chamomile extract is chosen from a variety of extracts and essences for this study. In situ composition of materials and plant extract are employed on cotton fabric. The optimal sample, which contains 0.5 w% gum tragacanth, 0.5 w% alginate, and 0.5 w% bacterial cellulose, has the best antibacterial features while being biocompatible.
Enhancing the Formulation of Chemically Modified Starch Bionanoparticles Through Ultrasonic Assisted Emulsification: A Parameter Study
Authors: Mohyuddin Maradiya , Rami Gaurang , Vora Jabali 
Published: January 2024

AbstractThe design of polymeric nanoparticles has gained significant attention for drug delivery and controlled release applications. Biocompatible and degradable polyesters have emerged as promising materials for this purpose. However, achieving precise control over the size of nanoparticles (NPs) is crucial to ensure selective delivery and avoid clearance by the reticuloendothelial system. This study investigates the impact of external parameters, including polymer concentration, sonication amplitude, and sonication time, on the preparation of polymeric NPs using starch butyrate (SB) via the single emulsification‐solvent evaporation (SE‐SE) technique with ultrasound assistance. Employing a Box–Behnken method, this study optimizes the conditions for nanoformulation, obtaining response surfaces that reveal the effects of these parameters on particle size. These findings highlight that sonication time is the most influential parameter, followed by sonication amplitude and polymer concentration. By utilizing the statistical model, this study predicts and controls the variables to achieve particle diameters ranging from 152 to 346 nm. The optimal conditions for NPs preparation involve a polymer concentration of 1 mg mL−1, 40% sonication amplitude, and a 30‐min sonication time, resulting in particle sizes of 142 nm. Furthermore, this model demonstrates the capability to develop nanoformulations with excellent size homogeneity, enhancing their attractiveness and efficacy in drug delivery applications.
Effect of pH on the Properties of Potato Flour Film‐Forming Dispersions and the Resulting Films
Authors: Fu Zong‐qiang , Li Yi , Guo Shao‐xiang , Yao Xu , Zheng Zi‐xu , Li Fei‐fei , Wu Min 
Published: January 2024

AbstractBiodegradable films are considered an alternative to petroleum‐based plastics to solve environmental problems. In this study, potato flour films are prepared with dispersions at pH 3, 5, 7, 9, and 11. The film‐forming dispersion at pH 7 shows the highest apparent viscosity. Dispersions at alkaline conditions show a reduction in particle size, resulting in a smooth film surface. Films at alkaline conditions present a yellow appearance and have the lower transmittance. The film at pH 5 has the highest retrogradation enthalpy and glass transition temperature, while its moisture content and solubility are the lowest. The water contact angle increases from 33.33° to 93.67° with the increase in pH. However, pH has no significant effect on the water vapor permeability. The tensile strength and elongation at break increase slightly with the increase in pH. Overall, pH modifies the properties of potato flour films. Film with appropriate performance can be selected based on actual needs, such as the use of packaging materials for food preservation.
A tough nutlet to crack: Resolving the phylogeny of Thesium (Thesiaceae), the largest genus in Santalales
Authors: García Miguel A. , Mucina Ladislav , Nickrent Daniel L. 
Published: January 2024

AbstractWith over 350 species, Thesium is the largest genus in Santalales. It is found on all continents except Antarctica; however, its highest diversity is in the Cape Floristic Region of South Africa where approximately half the species occur. Thesium samples of ca. 590 collections from throughout its entire geographic range were obtained and nuclear ribosomal ITS sequenced from 396 accessions representing 196 named taxa and 30 currently unnamed taxa for a total of ca. 230 species. In addition, two chloroplast genome spacers (trnDT, trnLF) were sequenced from 269 and 315 accessions, respectively. Maximum parsimony, maximum likelihood and Bayesian methods were employed to generate gene trees and infer phylogenies. The value of the morphological characters traditionally used in the taxonomy of the genus and previous infrageneric classifications are discussed. Broad scale relationships were generally congruent among the ITS and the chloroplast trees. For example, both the nuclear and chloroplast trees support the presence of Eurasian and African clades. In contrast, major incongruence was detected between nuclear and chloroplast trees for a number of taxa including the recently described T. nautimontanum that is sister to the entire African clade on the ITS tree. Although the causes of this incongruence are currently unknown, a novel form of chloroplast capture is hypothesized. A hypothesis of the biogeographical history of the genus based on our molecular phylogeny is presented.
Report of the Nomenclature Committee for Fungi: 23
Authors: May Tom W. 
Published: January 2024

SummaryFive lists of names for protection assembled by working groups set up under Art. F.2.1 are approved. The lists contain one family name along with 39 names of genera and 10 names of species, to be treated as protected against listed and unlisted synonymous or homonymous names. Lists were compiled by working groups (WGs) approved by the International Commission on the Taxonomy of Fungi and the Nomenclature Committee for Fungi: on Homobasidiomycetes, Heterobasidiomycetes, Orbiliomycetes, Sordariomycetes (excluding Diaporthales, Hypocreales and Magnaporthales) and Miscellaneous fungi. The list from the Pyricularia/Magnaporthe WG did not require any formal action. Acceptance of two proposals to conserve names under Art. 14.1 associated with two of the names (Typhula, Typhulaceae) originally included in the list for protection from the Homobasidiomycetes WG led to the removal of those two names from consideration for protection. The names Drechslerella and Dactylellina, initially included in the list from the Orbiliomycetes WG, were withdrawn from that list. In relation to two proposals under Art 14.1 that are connected to the list from the Dothideomycetes WG, the following family name is not recommended for conservation: Pleomassariaceae against Prosthemiaceae; and the following generic name is not recommended for conservation: Pleomassaria against Prosthemium. As a result of consideration of the set of proposals that contained the two proposals connected to Typhulaceae, the following family name is recommended for conservation: Phyllotopsidaceae against Sclerotiaceae; the following two names of genera are recommended for conservation: Macrotyphula against Sclerotium, and Typhula with a conserved type; and the following species name is recommended for rejection under Art. 56: Sclerotium fulvum. A modified proposal resulted in a recommendation to conserve the name Peziza medicaginis against Sporonema phacidioides. The generic name Discosphaera Haeckel (Algae) is recommended for conservation against Discosphaera Dumort. (Fungi). Two individual proposals under Art. 14.1 are listed as having been withdrawn.
Bilomas in a dog secondary to a bite injury
Authors: Pujante Santiago , Mena Beatriz , Carrillo Juana , Soler Marta , Agut Amalia 
Published: January 2024

AbstractAn entire, Pomeranian, female dog was presented to the emergency unit with anorexia, fever, abdominal pain, jaundice and an inguinal hernia. The patient had been bitten by a dog 2 weeks earlier and was on antibiotics and non‐steroidal anti‐inflammatory drug without improvement. Ultrasonographic exam showed peritoneal effusion and hepatic cystic lesions. Fluid analysis was compatible with bile. Bilomas and an inguinal hernia were diagnosed. Computed tomography scan did not reveal the origin of the bilomas. Ultrasound‐guided drainage of the bilomas resulted in a slight improvement. The patient worsened, and an exploratory laparotomy was recommended. The owner declined the surgery due to a guarded prognosis and the dog was humanely euthanased. On postmortem examination, a small laceration of the common bile duct was observed, which was probably the cause of the biliary peritonitis. To the authors’ knowledge, this report represents the first description of intrahepatic bilomas secondary to a bite injury.
Performance investigation of poly(vinylidene fluoride‐cohexafluoropropylene) membranes containing SiO2 nanoparticles in a newly designed single vacuum membrane distillation system
Authors: Hussain mana Turki , Alam Javed , Shukla Arun Kumar , Alkhudhiri Abdullah , Mohammed Abdullah Najib , Alhoshan Mansour 
Published: January 2024

AbstractThe current study focuses on the development of a superhydrophobic poly(vinylidene fluoride‐cohexafluoropropylene) nanocomposite membrane suitable for vacuum membrane distillation by incorporating SiO2 nanoparticles. At loading hydrophobic nano‐SiO2 particle concentration (0.50–1.50 wt.%), the developed nanocomposite membranes are optimized in terms of vacuum membrane distillation performance. The influence of temperature, vacuum pressure, and feed water flow is studied for desalinating high‐salinity brine. The results show that the developed vacuum distillation membrane is capable of 95% salt rejection during the treatment of a highly saline feed (65,000 ppm) at fixed flow rates of 120 L/h saline feed and different operating conditions consisting of feed inlet temperatures ranging from 40°C to 70°C and distillate inlet temperatures of 7–15°C. The vacuum membrane distillation process achieves 0.38–1.66% water recovery with increasing concentration factor, meaning that recovery is increased, and shows a specific electrical energy consumption of 5.16–23.90 kWh/m3 for product water. Overall, the newly designed membrane demonstrates suitability for a vacuum membrane distillation system.Practitioner Points

Desalinate high‐salinity brine (TDS > 35,000 ppm) using a vacuum membrane distillation system.
A hydrophobic PVDF‐HFP/SiO2 nanocomposite membrane development for vacuum membrane distillation.
A newly designed single vacuum membrane distillation system for RO brine treatment.
LGBTQ Stigma
Authors: Earnshaw Valerie A. , Logie Carmen , Wickersham Jeffrey A. , Kamarulzaman Adeeba 
Published: January 2024

AbstractLesbian, gay, bisexual, transgender, and/or queer (LGBTQ) individuals face significant stigma globally. Examples of stigma range from extreme acts of violence, such as murder, to more subtle yet pervasive forms of marginalization and social exclusion, such as being socially rejected, denied employment opportunities, and given poor healthcare. Stigma has been identified as a fundamental cause of global LGBTQ health inequities. This chapter summarizes research on and theory that defines LGBTQ stigma, documents ways in which stigma is manifested and experienced by LGBTQ individuals, articulates how stigma leads to health inequities among LGBTQ populations, and identifies evidence-based intervention strategies to address LGBTQ stigma. Moreover, recommendations for addressing stigma to promote LGBTQ health equity globally are provided. As examples, promoting policy change and investing in social norm campaigns can reduce stigma at the structural level, enhancing education and providing opportunities for interpersonal contact can reduce stigma among individuals who perpetrate stigma, and bolstering resilience can protect LGBTQ individuals from stigma. Intervention strategies that have been developed in the Global South are being applied in the Global North (e.g., participatory theatre) and vice versa. As the field moves toward addressing stigma to achieve LGBTQ health equity, it is worth bearing in mind that stigma is neither fixed nor insurmountable. Rather, it is malleable and intervenable: it has changed and will continue to change with time. Public health researchers, practitioners, policy makers, and other stakeholders have key roles to play in advocating for continued change in LGBTQ stigma worldwide.