bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green, Safe, and Reliable Synthesis of Bimetallic MOF‐808 Nanozymes With Enhanced Aqueous Stability and Reactivity for Biological Applications
Authors: Simms Charlotte , Mullaliu Angelo , de de Azambuja Francisco , Aquilanti Giuliana , Parac‐Vogt Tatjana N. 
Published: November 2023

AbstractBimetallic metal‐organic frameworks (MOFs) are promising nanomaterials whose reactivity towards biomolecules remains challenging due to issues related to synthesis, stability, control over metal oxidation state, phase purity, and atomic level characterization. Here, these shortcomings are rationally addressed through development of a synthesis of mixed metal Zr/Ce‐MOFs in aqueous environment, overcoming significant hurdles in the development of MOF nanozymes, sufficiently stable on biologically relevant conditions. Specifically, a green and safe synthesis of Zr/Ce‐MOF‐808 is reported in water/acetic acid mixture which affords remarkably water‐stable materials with reliable nanozymatic reactivity, including MOFs with a high Ce content previously reported to be unstable in water. The new materials outperform analogous bimetallic MOF nanozymes, showcasing that rational synthesis modifications could impart outstanding improvements. Further, atomic‐level characterization by X‐ray Absorption Fine Structure (XAFS) and X‐ray Diffraction (XRD) confirmed superior nanozymes arise from differences in the synthetic method, which results in aqueous stable materials, and Ce incorporation, which perturbs the ligand exchange dynamics of the material, and could ultimately be used to fine tune the intrinsic MOF reactivity. Similar rational strategies which leverage metals in a synergistic manner should enable other water‐stable bimetallic MOF nanozymes able to surpass existing ones, laying the path for varied biotechnological applications.
Fabrication of Zn–Air Battery with High Output Capacity Under Ultra‐Large Current
Authors: Zhang Xiuli , Wu Xueyan , Lv Yan , Guo Jixi , Liang Na , Guo Renhe , Zhu Yingfu , Liu Huibiao , Jia Dianzeng 
Published: November 2023

AbstractZn–air battery (ZAB) is advocated as a more viable option in the new‐energy technology. However, the limited‐output capacity at a high current density impedes the driving range in power batteries substantially. Here, a novel heterojunction‐based graphdiyne (GDY) and Ag29Cu7 alloy quantum dots (Ag29Cu7 QDs/GDY) for constructing a high‐performance aqueous ZAB are fabricated. The as‐fabricated ZAB achieves discharge at up to 100 mA cm−2 (the highest value ever reported) along with a remarkable output specific capacity of 786.2 mAh g−1Zn, which is mainly benefitted from the binary‐synergistic effect toward a stable triple‐phase interface for air electrode induced by the Ag29Cu7 QDs and GDY in harsh base, together with the decreasing reaction energy barrier and polarization. The results outperform the superior reports discharging at low current and will bring breakthrough progress toward the practical applications of ZAB on large power supply facilities.
Green Synthesis and Biosafety Assessment of MXene
Authors: Zhang Shengmin , Meng Ling , Hu Ying , Yuan Zihan , Li Jianhua , Liu Hong 
Published: November 2023

AbstractThe rise of MXene‐based materials with fascinating physical and chemical properties has attracted wide attention in the field of biomedicine, because it can be exploited to regulate a variety of biological processes. The biomedical applications of MXene are still in its infancy, nevertheless, the comprehensive evaluation of MXene's biosafety is desperately needed. In this review, the composition and the synthetic methods of MXene materials are first introduced from the view of biosafety. The evaluation of the interaction between MXene and cells, as well as the safety of different forms of MXene applied in vivo are then discussed. This review provides a basic understanding of MXene biosafety and may bring new inspirations to the future applications of MXene‐based materials in biomedicine.
Confinement Effect and 3D Design Endow Unsaturated Single Ni Atoms with Ultrahigh Stability and Selectivity toward CO2 Electroreduction
Authors: Ping Dan , Huang Siguang , Wu Shide , Zhang Yifei , Wang Shiwen , Yang Xuzhao , Han Lifeng , Tian Junfeng , Guo Dongjie , Qiu Hua‐Jun , Fang Shaoming 
Published: November 2023

AbstractDeveloping single‐atomic catalysts with superior selectivity and outstanding stability for CO2 electroreduction is desperately required but still challenging. Herein, confinement strategy and three‐dimensional (3D) nanoporous structure design strategy are combined to construct unsaturated single Ni sites (Ni‐N3) stabilized by pyridinic N‐rich interconnected carbon nanosheets. The confinement agent chitosan and its strong interaction with g‐C3N4 nanosheet are effective for dispersing Ni and restraining their agglomeration during pyrolysis, resulting in ultrastable Ni single‐atom catalyst. Due to the confinement effect and structure advantage, such designed catalyst exhibits a nearly 100% selectivity and remarkable stability for CO2 electroreduction to CO, exceeding most reported state‐of‐the‐art catalysts. Specifically, the CO Faradaic efficiency (FECO) maintains above 90% over a broad potential range (‐0.55 to ‐0.95 V vs. RHE) and reaches a maximum value of 99.6% at a relatively low potential of ‐0.67 V. More importantly, the FECO is kept above 95% within a long‐term 100 h electrolyzing. Density functional theory (DFT) calculations explain the high selectivity for CO generation is due to the high energy barrier required for hydrogen evolution on the unsaturated Ni‐N3. This work provides a new designing strategy for the construction of ultrastable and highly selective single‐atom catalysts for efficient CO2 conversion.
Crafting Corporate Sustainability Strategy
Authors: Beckmann Markus , Becker Thomas , Zipse Oliver 
Published: November 2023

AbstractCompanies are increasingly integrating sustainability into their strategies. The main drivers include changing societal expectations, regulatory policies, financial market pressures, and changing customer behavior. The generic business benefits of sustainability include securing the license to operate, managing risk, reducing costs, and increasing revenues through improved innovation and future market opportunities. How companies realize these generic benefits depends on their specific position and the maturity of their sustainability strategy. Strategies with high maturity do not treat sustainability as a separate add-on, but instead integrate it into how the company creates value. Moreover, sustainability strategies that aim at real life cycle improvements, such as in the case of climate-oriented strategies, need not only to integrate firm operations, but also to consider the entire value chain. This integrated approach to sustainability changes the entire strategy process. Its first step, environmental scanning, needs to consider a richer set of factors and stakeholders. Regarding strategy formulation, the strategy’s effectiveness and credibility depend on reliable target setting, such as in the case of Science-Based Targets for climate action. Strategy implementation requires an integrated approach to management that also engages relevant value chain partners. Finally, strategy evaluation and control must produce reliable data that can inform integrated reporting. Integrating sustainability throughout the full strategy process adds complexity while significantly increasing the potential for long-term sustainability and business benefits.
The Future of Corporate Disclosure
Authors: Fischer Thomas , Adolph Jennifer , Schober Markus , Townend Jonathan , Zipse Oliver 
Published: November 2023

AbstractThe growing interest in a company’s sustainability strategy and performance means that solely providing financial information in corporate disclosures will no longer fulfil stakeholder needs in the future. Traditional financial reporting is primarily targeted at capital providers and therefore provides information on the company’s current and future financial performance. Today, a broader focus on non-financial, sustainability-related aspects is required to meet the information needs of other stakeholders, such as employees, customers, suppliers, government and society. Non-financial information is also increasingly important for investors to assess a firm’s risks and opportunities related to sustainability issues, such as climate change, and to understand how the firm is preparing itself for these future challenges. The transition of non-financial reporting—in particular, sustainability reporting—is evolving from voluntarily applied frameworks to mandatory regulatory requirements by standard-setting institutions. The aim is to provide higher transparency and comparability and to build the basis for linking the former separate financial and sustainability reports of a firm on a concise integrated report. A key challenge is the choice (and clear definition) of appropriate performance indicators to achieve comparability between firms. As a result, new rules and formats for corporate reports and for financial, as well as non-financial, disclosures are already appearing on the horizon and will sustainably change the future of corporate reporting. Adapting to these new regulations while balancing the interests of multiple stakeholders will become a continuous challenge for companies and will require them to engage in comprehensive, integrated thinking.
The Power of Technological Innovation
Authors: Franke Jörg , Wasserscheid Peter , Ihne Thorsten , Lamp Peter , Guldner Jürgen , Zipse Oliver 
Published: November 2023

AbstractAchieving the urgent need for rapid decarbonization to meet the 1.5 °C target requires disruptive technological change. In the automotive industry, technological progress is closely linked to improved sustainability, and sustainability goals drive the need for technological innovation. However, new technologies in the mobility sector are fraught with uncertainties that challenge both original equipment manufacturers (OEMs) and their stakeholders, such as suppliers, customers, and policy-makers. Therefore, this chapter focuses on the technical, economic, and environmental evaluation of alternative powertrain concepts and the management of uncertainties associated with emerging technological innovation as part of the broader transition to net zero.Electric mobility plays a central role in the sustainability transition and is characterized by a high degree of variance. Battery electric vehicles (BEVs) are expected to dominate private transport in the future due to their greenhouse gas and pollutant-free operation and high efficiency. In addition to charging infrastructure, the technical challenges currently lie primarily in cell chemistry and power electronics. Advances in battery technology and infrastructure electrification will help eliminate the range problem in the future. Another important future fuel is hydrogen. One application is the fuel cell vehicle, which combines the advantages of a chemical energy carrier with high gravimetric energy density with those of an electrical energy converter. Hydrogen also plays an important role as an energy carrier for specific energy supply processes in manufacturing processes and simplifies the transport of regeneratively generated energy. In addition, hybrid vehicles are a transitional technology, and alternative fuel internal combustion engines can contribute to the decarbonization of the existing fleet and to specific applications.This chapter assesses the performance of alternative powertrains; highlights the interrelationship between powertrain systems, energy ecosystems, and sustainability goals; and identifies future research directions for electric and hydrogen mobility.
The Road to Net Zero and Beyond
Authors: Beckmann Markus , Feige Irene 
Published: November 2023

AbstractThe Road to Net Zero is an iterative, rather than a linear journey. This concluding chapter revisits the insights and lessons learned from each preceding chapter, while also looking beyond to reflect on overarching lines of thought. First, the Road to Net Zero calls for both integrative thinking and integrative management. As a moving target, sustainability is a race that cannot be won alone, thereby demanding robust collaboration with multiple stakeholders. Second, the Road to Net Zero is a data-driven journey that requires measurable indicators and targets, and implies digitization to ensure transparency across value chains. Third, sustainability transformation transcends mere decarbonization based on emission pathways and reducing negative impacts. It also involves creating balanced, sustainable business solutions that generate positive societal impacts. Lastly, championing change for sustainability necessitates a multitude of innovations in technology, management, and policy. Catalyzing these innovations calls for the persistent advancement and refinement of innovative, inclusive, and effective platforms for interdisciplinary, cross-sector, and global learning.
Hide and seek: how PDFs can conceal new physics
Authors: Hammou Elie , Kassabov Zahari , Madigan Maeve , Mangano Michelangelo L. , Mantani Luca , Moore James , Alvarado Manuel Morales , Ubiali Maria 
Published: November 2023

Abstract
The interpretation of LHC data, and the assessment of possible hints of new physics, require the precise knowledge of the proton structure in terms of parton distribution functions (PDFs). We present a systematic methodology designed to determine whether and how global PDF fits might inadvertently ‘fit away’ signs of new physics in the high-energy tails of the distributions. We showcase a scenario for the High-Luminosity LHC, in which the PDFs may completely absorb such signs of new physics, thus biasing theoretical predictions and interpretations. We discuss strategies to single out the effects in this scenario, and disentangle the inconsistencies that stem from them. Our study brings to light the synergy between the high luminosity programme at the LHC and future low-energy non-LHC measurements of large-x sea quark distributions. The analysis code used in this work is made public so that any users can test the robustness of the signal associated to a given BSM model against absorption by the PDFs.
First-site-metastasis pattern in patients with inoperable stage III NSCLC treated with concurrent chemoradiotherapy with or without immune check-point inhibition: a retrospective analysis
Authors: Hofstetter Kerstin , Taugner Julian , Käsmann Lukas , Mansoorian Sina , Flörsch Benedikt , Eze Chukwuka , Tufman Amanda , Reinmuth Niels , Duell Thomas , Belka Claus , Manapov Farkhad 
Published: November 2023

Abstract
Purpose
The aim of this study was to investigate a first-site-metastasis pattern (FSMP) in unresectable stage III NSCLC after concurrent chemoradiotherapy (cCRT) with or without immune checkpoint inhibition (ICI).

Methods
We defined three patient subgroups according to the year of initial multimodal treatment: A (2011–2014), B (2015–2017) and C (2018–2020). Different treatment-related parameters were analyzed. Observed outcome parameters were brain metastasis-free survival (BMFS), extracranial distant metastasis-free survival (ecDMFS) and distant metastasis-free survival (DMFS).

Results
136 patients treated between 2011 and 2020 were included with ≥ 60.0 Gy total dose and concurrent chemotherapy (cCRT); thirty-six (26%) received ICI. Median follow-up was 49.7 (range:0.7–126.1), median OS 31.2 (95% CI:16.4–30.3) months (23.4 for non-ICI vs not reached for ICI patients, p = 0.001).
Median BMFS/ecDMFS/DMFS in subgroups A, B and C was 14.9/16.3/14.7 months, 20.6/12.9/12.7 months and not reached (NR)/NR/36.4 months (p = 0.004/0.001/0.016).
For cCRT+ICI median BMFS was 53.1 vs. 19.1 months for cCRT alone (p = 0.005). Median ecDMFS achieved 55.2 vs. 17.9 (p = 0.003) and median DMFS 29.5 (95% CI: 1.4–57.6) vs 14.93 (95% CI:10.8–19.0) months (p = 0.031), respectively.
Multivariate analysis showed that age over 65 (HR:1.629; p = 0.036), GTV ≥ 78 cc (HR: 2.100; p = 0.002) and V20 ≥ 30 (HR: 2.400; p = 0.002) were negative prognosticators for BMFS and GTV ≥ 78 cc for ecDMFS (HR: 1.739; p = 0.027).
After onset of brain metastasis (BM), patients survived 13.3 (95% CI: 6.4–20.2) months and 8.6 months (95% CI: 1.6–15.5) after extracranial-distant-metastasis (ecDM). Patients with ecDM as FSMP reached significantly worse overall survival of 22.1 (range:14.4–29.8) vs. 40.1 (range:18.7–61.3) months (p = 0.034) in the rest of cohort. In contrast, BM as FSMP had no impact on OS.

Conclusion
This retrospective analysis of inoperable stage III NSCLC patients revealed that age over 65, V20 ≥ 30 and GTV ≥ 78 cc were prognosticators for BMFS and GTV ≥ 78 cc for ecDMFS. ICI treatment led to a significant improvement of BMFS, ecDMFS and DMFS. ecDM as FSMP was associated with significant deterioration of OS, whereas BM as FSMP was not.
Future weakening of southeastern tropical Atlantic Ocean interannual sea surface temperature variability in a global climate model
Authors: Prigent Arthur , Imbol Koungue Rodrigue Anicet , Lübbecke Joke F. , Brandt Peter , Harlaß Jan , Latif Mojib 
Published: November 2023

AbstractFuture changes in the southeastern tropical Atlantic interannual sea surface temperature (SST) variability in response to increasing greenhouse gas concentrations are investigated utilizing the global climate model FOCI. In that model, the Coastal Angola Benguela Area (CABA) is among the regions of the tropical Atlantic that exhibits the largest surface warming. Under the worst-case scenario of the Shared Socioeconomic Pathway 5-8.5 (SSP5-8.5), the SST variability in the CABA decreases by about 19% in 2070–2099 relative to 1981–2010 during the model’s peak interannual variability season May–June–July (MJJ). The weakening of the MJJ interannual temperature variability spans the upper 40 m of the ocean along the Angolan and Namibian coasts. The reduction in variability appears to be related to a diminished surface-layer temperature response to thermocline-depth variations, i.e., a weaker thermocline feedback, which is linked to changes in the mean vertical temperature gradient. Despite improvements made by embedding a high-resolution nest in the ocean a significant SST bias remains, which might have implications for the results.
Placental progesterone and its receptor in HIV-infected pre-eclamptic women
Authors: Sewnarain Serisha , Singh Shoohana , Naicker Thajasvarie 
Published: November 2023

AbstractGiven the high prevalence of HIV infection and pre-eclampsia (PE) in South Africa, this study evaluated and compared the placental immunostaining of progesterone (P) and progesterone receptors (PR) in the synergy of HIV-infected PE compared to normotensive pregnant women using immunohistochemistry interfaced with morphometric image analysis. Progesterone immunostaining was expressed widely across exchange and conducting villi within mesenchymal, endothelial, and trophoblast cells. In contrast, PR was expressed within syncytiotrophoblasts and was absent within endothelial cells. In exchange villi, P and PR immuno-expression was significantly lower in PE compared to the normotensive group (p = < 0.0001 and p = < 0.0001, respectively) and within the early-onset pre-eclampsia (EOPE) compared to the late-onset pre-eclampsia (LOPE) group (p = < 0.0001 and p = < 0.0001, respectively). Progesterone immuno-expression was significantly lower in the HIV+ compared to the HIV− group (p = < 0.0001), whilst PR was non-significant. In conducting villi, P and PR immuno-expression was significantly lower in the EOPE compared to the LOPE group (p = < 0.0001 and p = < 0.0001, respectively) and in the HIV+ compared to the HIV− group (p = < 0.0001 and p = 0.0009, respectively). Progesterone immuno-expression was slightly higher in the PE compared to normotensive group, and PR immuno-expression was non-significant. There was a significant difference between P and PR within exchange versus conducting villi regardless of pregnancy type, with villi type accounting for 34.47% and 15.28% of total variance for P and PR, respectively. Placental P and PR immuno-expression is downregulated in the duality of PE and HIV+ infection. The use of combined antiretroviral therapy (cART) may result in defective P synthesis, which causes insufficient binding to its receptors. Consequently, PI3K/AKT, JAK-STAT, and MAPK signalling pathways are affected, impairing trophoblast invasion and leading to pre-eclampsia development. Notably, the decrease in P and PR immuno-expression in EOPE validates their effect on placentation.
Cow’s Milk-related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6–12 months: a cross-sectional study
Authors: Jankiewicz Mateusz , Ahmed Fatme , Bajerova Katerina , Carvajal Roca Maria Eva , Dupont Christophe , Huysentruyt Koen , Kuitunen Mikael , Meyer Rosan , Pancheva Rouzha , Koninckx Carmen Ribes , Salvatore Silvia , Shamir Raanan , Staiano Annamaria , Vandenplas Yvan , Szajewska Hania 
Published: November 2023

AbstractThe Cow’s Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating cow’s milk-related symptoms. Previous studies have focused on providing CoMiSS values for healthy and symptomatic infants aged 0–6 months. However, there is a notable gap in the literature concerning CoMiSS values for infants older than 6 months. This cross-sectional study aimed to determine CoMiSS values in presumed healthy infants who have completed 6 months and are up to 12 months old, hereafter referred to as 6 to 12 months old. Physicians from six European countries prospectively determined CoMiSS values in infants attending well-child clinics. Exclusion criteria included preterm delivery, acute or chronic disease, and the consumption of a therapeutic formula, dietary supplements (except vitamins), or medication. The following information was collected: gestational age, gender, age, type of feed (breast milk or infant formula), and complementary feeding. Descriptive statistics were summarized with mean and standard deviation for normally distributed continuous variables, median and IQR for non-normally distributed variables, and differences in CoMiSS values were analyzed with appropriate tests. Data from 609 infants were obtained. The overall median (Q1–Q3) CoMiSS values were 3 (1–5). Significant differences were found across age groups (p < 0.001), but not across groups based on gender (p = 0.551) or feeding type (p = 0.880). Conclusions: This study provided CoMiSS values in presumed healthy infants aged 6–12 months. Additional studies should be conducted to establish the use of CoMiSS to assess cow’s milk-related symptoms in infants 6 months and older.

What is Known:• The Cow’s Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating symptoms related to cow’s milk.• CoMiSS values for presumed healthy infants aged 0-6 months infants are already available.

What is New:• CoMiSS values in European infants aged 6-12 months are provided.• These CoMiSS values differed across various age groups but not across groups based on gender or feeding type.