bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moving towards One Health surveillance of antibiotic resistance in France: a semi-quantitative evaluation of the level of collaboration within the national surveillance system
Authors: Collineau Lucie , Rousset Léo , Colomb-Cotinat Mélanie , Bordier Marion , Bourely Clémence 
Published: February 2024

Abstract

Objectives
Collaboration between surveillance programmes is the keystone of One Health surveillance and international organizations call for integrated surveillance systems to manage antibiotic resistance (ABR). In France, the ABR surveillance system covers human, animal, food and the environment sectors, but appears to be fragmented, questioning its level of integration. This study aimed to evaluate collaboration within this system and to formulate recommendations towards more integration.

Methods
ECoSur, a semi-quantitative tool, was used to evaluate collaboration between surveillance programmes. A total of 31 attributes were evaluated using information from the literature and 52 interviews with surveillance actors from all four sectors. Evaluation results were visualized via three output figures displaying aspects related to governance and functionality of collaboration. Results were validated by an expert committee.

Results
Overall, the French collaborative strategy for ABR surveillance was well formalized and relevant to its objectives. However, a cross-sectoral coordination body was lacking to help with its practical implementation. The environmental sector was largely uncovered, but its integration appeared necessary to meet the strategy objectives. Data sharing and joint data analyses between programmes were insufficient, mainly due to limited resources and data interoperability issues. Collaboration was operational for internal and external communication of the results. Twelve recommendations were suggested to decision makers to foster collaboration within the French surveillance system and feed future strategies against ABR.

Conclusions
This first evaluation of collaboration within the French ABR surveillance system produced concrete recommendations to move towards One Health integrated surveillance. Both the approach and the findings could be of interest to other countries.
The Acute Effect of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers: A Randomized Trial
Authors: Kimura Reona , Schwartz Jonathon A , Romeiser Jamie L , Senzel Lisa , Galanakis Dennis , Halper Darcy , Bennett-Guerrero Elliott 
Published: February 2024

Abstract

Background
Chamomile administration may have desirable effects in the perioperative setting. Current practice, however, discourages perioperative chamomile use due to a theoretical increase in bleeding. Therefore, we evaluated if chamomile acutely (within 4 h of ingestion) prolongs coagulation assays.

Methods
Eight healthy volunteers were randomized to receive 2 interventions in a crossover design: (a) single dose of chamomile extract capsule (500 mg) and (b) single dose of chamomile tea (3 g in 150 mL water). Interventions were separated at least 3 days apart from each other. Blood was sampled pre-ingestion, 2 h post-ingestion, and 4 h post-ingestion for each intervention. The primary outcome was the maximal change in prothrombin time (PT) before vs after each intervention. Secondary outcomes included changes in international normalized ratio, activated partial thromboplastin time, thrombin time, reptilase time, and fibrinogen levels.

Results
All 8 subjects completed the study. The average pre-ingestion PT values for tea and capsules were 11.9 (1.1) s and 12.0 (0.9) s, respectively. Tea significantly increased the average maximum PT by 0.7 (0.2) s (P = 0.0078). Extract capsules increased the maximum PT by 0.3 (0.2) s (P = 0.06). Neither PT prolongation met the predefined 10% threshold for clinical significance. No significant changes in secondary outcomes were observed.

Conclusions
Chamomile tea ingestion prolongs PT. However, the clinical significance of this is unclear at this time and warrants further investigation.
ClinicalTrials.gov Registration Number: NCT05272475.
Are active and passive social media use related to mental health, wellbeing, and social support outcomes? A meta-analysis of 141 studies
Authors: Godard Rebecca , Holtzman Susan 
Published: February 2024

Abstract
The relationships between active (e.g., creating content) and passive (e.g., scrolling) social media (SM) use (SMU) and mental health, wellbeing, and social support outcomes have received significant attention, yet findings have been mixed. We conducted a meta-analysis of 141 studies (N ≈ 145,000) containing 897 effect sizes (ESs) between active and passive SMU and 13 outcomes. Most ESs were negligible (|r| &lt; .10), with the exception of between-person associations for active SMU and greater online support (r = .34), wellbeing (r = .15), positive affect (r = .11), and symptoms of anxiety (r = .12), and passive SMU and greater online support (r = .15). Moderator analyses revealed that passive use was associated with worse emotional outcomes in general SM contexts, but not in the context of SM groups. User age also emerged as an important contextual factor. Implications for future research, theory development, and healthy SMU are discussed.
Parasite evolution of host manipulation strategies with fluctuating ecological dynamics
Authors: Oliver Megan Grace , Best Alex 
Published: February 2024

Abstract
Trophically transmitted parasites often infect an intermediate prey host and manipulate their behaviour to make predation more likely, thus facilitating parasite transmission to the definitive host. However, it is unclear when such a manipulation strategy should be expected to evolve. We develop the first evolutionary invasion model to explore the evolution of manipulation strategies that are in a trade-off with parasite production of free-living spores. We find that the size of the susceptible prey population together with the threat of predation drives manipulation evolution. We find that it is only when the susceptible prey population is large and the threat of predation is relatively small that selection favours manipulation strategies over spore production. We also confirm that the system exhibits cyclic population dynamics, and this can influence the qualitative direction of selection.
Inexact augmented Lagrangian method-based full-waveform inversion with randomized singular value decomposition
Authors: Li Jiahang , Mikada Hitoshi , Takekawa Junichi 
Published: February 2024

Abstract
The main advantage of full-waveform inversion (FWI) is the ability to obtain useful subsurface structure information, such as velocity and density, from complex seismic data. We have developed a novel inversion algorithm to improve the capability of FWI to achieve high-resolution imaging, even under complex conditions caused by random noise contamination, initial model dependence, or the selection of parameters to be estimated. Our algorithm considers an effective image processing and dimension reduction tool, randomized singular value decomposition-weighted truncated nuclear norm regularization, for embedding FWI to achieve high-resolution imaging results. This algorithm obtains a truncated matrix approximating the original matrix by reducing the rank of the velocity increment matrix, thus achieving the truncation of noisy data, with the truncation range controlled by weighted truncated nuclear norm regularization. Subsequently, we employ an inexact augmented Lagrangian method algorithm in the optimization to compress the solution space range, thus relaxing the dependence of FWI and randomized singular value decomposition-weighted truncated nuclear norm regularization on the initial model and accelerating the convergence rate of the objective function. We tested on one set of synthetic data, and the results show that, compared with traditional FWI, our method can more effectively suppress the impact of random noise, thus obtaining higher resolution and more accurate subsurface model information. This work indicates that the combination of randomized singular value decomposition-weighted truncated nuclear norm regularization and FWI is an effective imaging strategy that can help to solve the challenges faced by traditional FWI.
Unfair competition in the Arab world: a remedy completing IP limits?
Authors: El Khoury Pierre 
Published: February 2024

Abstract
Some Arab countries incorporate unfair competition clauses within their IP laws, while others address these issues through separate legal frameworks, adding complexity to the legal landscape. The crucial distinction between clauses filling gaps in IP laws and the broader concept of unfair competition is vital for establishing a clear and comprehensive legal environment conducive to sustained innovation and equitable business practices. Fortifying IP protection and safeguards against unfair competition in the Arab region can unlock the full potential of its innovation narrative. This approach fosters an environment where creativity thrives, securely anchored in legal principles. Viewing unfair competition rules not as replacements but as complementary measures enhances overall protection. By aligning these rules with the ongoing wave of innovation, the Arab world can establish a framework that not only attracts talents but also ensures a harmonious balance between fostering creativity and safeguarding IP rights. This presents a promising avenue for the collective pursuit of progress and prosperity in the region.
Seven-year prospective study on yearly incidence of Orbivirus infection of captive white-tailed deer and potential Culicoides vectors
Authors: Becker Michael , Gentry Glen , Husseneder Claudia , Foil Lane 
Published: February 2024

Abstract
Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) are arthropod-borne viruses that are transmitted by biting midges in the genus Culicoides (Diptera: Ceratopogonidae) and can cause hemorrhagic disease in certain ruminants. The objectives of this study were to measure the incidence of BTV and EHDV infections in captive white-tailed deer herd as well as tissues and corresponding presence of Culicoides midges at a location near Clinton, LA. During a 7-yr study with yearly outbreaks of hemorrhagic disease in the deer herd, 15 species of Culicoides were captured using Centers for Disease Control (CDC) black light traps. Reverse transcriptase quantitative polymerase chain reaction (PCR) was performed to screen for BTV and EHDV in pools of midges and tissues of deer. From 2012 to 2018, 1,711 pools of midges representing 24,859 specimens were tested, and specimens from 5 of the 15 collected species (Culicoides debilipalpis, Culicoides stellifer, Culicoides venustus, Culicoides haematopotus, and Culicoides crepuscularis) were found to be PCR positive for BTV and EHDV. Most of the BTV-positive pools of biting midges were from specimens of C. debilipalpis and C. stellifer, and most of the EHDV-positive pools were from specimens of C. venustus and C. stellifer. During the 7-yr period, 112 white-tailed deer that died at the study location were PCR positive for BTV or EHDV: detected BTV serotypes were 10 and 12 and EHDV serotypes were 1, 2, and 6. There was a significant increase in BTV/EHDV antibody prevalence in white-tailed deer during the study; antibody-positive rates increased from 15% to 78% in the deer herd of approximately 100 animals.
Will Bazball finally knock its critics for six?
Authors: Newans Tim , Drovandi Christopher 
Published: February 2024

Abstract
“Bazball” describes an aggressive, high-risk, high-reward style of cricket. But is it even a tangible phenomenon? And is it likely to improve the England men's team's chances on their Test tour of India in February 2024? Tim Newans and Christopher Drovandi offer some statistical speculation
Examining the Intersection of Strategic Thinking and Continuous Process Improvement Through the Lens of Military Medical Education to Build a Novel Model
Authors: Lazarus Melanie M , Bush Ruth L , McNeil Sara 
Published: February 2024

ABSTRACT
In 2020, the U.S. Air Force School of Aerospace Medicine hired its first civilian dean since its founding in 1918, tasked with building the school’s first strategic plan to modernize and improve the institution. Using a combination of military continuous process improvement and academic strategic thinking, the dean produced a highly successful strategic plan. However, its resource-heavy and time-consuming methodology made it difficult to replicate. This study aimed to create a novel and streamlined strategic planning model that combined best practices from continuous process improvement and strategic thinking without redundancy. A qualitative descriptive case study was used to analyze the detailed efforts through content analysis of 150 pages of documentation. A hybrid approach to coding uncovered 44 deductive codes and 5 inductive codes from 10 strategic tools. Results indicated a converging relationship between all strategic processes tested—strategic planning, strategic thinking, and continuous process improvement and their associated tools. A five-step model called the Triple “O” OODA Loop was created, combining best practice tools from strategic planning (purpose trident and SWOT analysis or strengths, weaknesses, opportunities, and threats), strategic thinking (Hot Spots scale and GOST framework or goals, objectives, strategies, and tactics) and continuous process improvement (phases 6–8).
Validating the sub-burst slope law: a comprehensive multisource spectro-temporal analysis of repeating fast radio bursts
Authors: Brown Katie , Chamma Mohammed A , Rajabi Fereshteh , Kumar Aishwarya , Rajabi Hosein , Houde Martin 
Published: February 2024

ABSTRACT
We conduct a comprehensive spectro-temporal analysis of repeating fast radio bursts (FRBs) utilizing nine distinct sources, the largest sample to date. Our data set includes 175 sub-bursts and 31 multicomponent bursts from 11 data sets, with centre frequencies ranging from 149 to 7144  MHz and durations spanning from 73 µs to 13 ms. Our findings are consistent with the predictions of the triggered relativistic dynamical model (TRDM) of FRB emission. We affirm the predicted quadratic relationship between sub-burst slope and central frequency, as well as a linear dependence of the sub-burst bandwidth on central frequency that is consistent with mildly relativistic Doppler broadening of narrow-band emission. Most importantly, we confirm the sub-burst slope law, a predicted inverse relationship between sub-burst slope and duration, to hold consistently across different sources. Remarkably, we also discover that the drift rates of multicomponent bursts follow the same law as the sub-burst slopes, an unexplained result that warrants further investigation. These findings not only support the TRDM as a viable framework for explaining several aspects of FRB emission, but also provide new insights into the complex spectro-temporal properties of FRBs.
Optimization of FFPE preparation and identification of gene attributes associated with RNA degradation
Authors: Lin Yu , Dong Zhou-Huan , Ye Ting-Yue , Yang Jing-Min , Xie Mei , Luo Jian-Cheng , Gao Jie , Guo An-Yuan 
Published: February 2024

Abstract
Formalin-fixed paraffin-embedded (FFPE) tissues are widely available specimens for clinical studies. However, RNA degradation in FFPE tissues often restricts their utility. In this study, we determined optimal FFPE preparation conditions, including tissue ischemia at 4°C (&lt;48 h) or 25°C for a short time (0.5 h), 48-h fixation at 25°C and sampling from FFPE scrolls instead of sections. Notably, we observed an increase in intronic reads and a significant change in gene rank based on expression level in the FFPE as opposed to fresh-frozen (FF) samples. Additionally, we found that more reads were mapped to genes associated with chemical stimulus in FFPE samples. Furthermore, we demonstrated that more degraded genes in FFPE samples were enriched in genes with short transcripts and high free energy. Besides, we found 40 housekeeping genes exhibited stable expression in FF and FFPE samples across various tissues. Moreover, our study showed that FFPE samples yielded comparable results to FF samples in dimensionality reduction and pathway analyses between case and control samples. Our study established the optimal conditions for FFPE preparation and identified gene attributes associated with degradation, which would provide useful clues for the utility of FFPE tissues in clinical practice and research.
NovelEGFRmutations in diffuse midline gliomas using cost-effective strategies: A report of 2 cases
Authors: Dandapath Iman , Sahu Saumya , Bhardwaj Supriya , Mohan Trishala , Chakraborty Rituparna , Singh Jyotsna , Singh Swati , Garg Ajay , Gupta Deepak , Sharma Mehar C , Suri Vaishali 
Published: February 2024

AbstractBackgroundDiffuse midline gliomas (DMGs) are malignant tumors predominantly affecting children, often leading to poor outcomes. The 2021 World Health Organization classification identifies 3 subtypes of DMGs, all characterized by the loss of H3K27 trimethylation. Here, we report 2 cases of DMG with Epidermal Growth Factor Receptor (EGFR) mutations within exon 20, contributing to the understanding of the molecular complexity of these pediatric brain tumors.MethodsAn economical immunohistochemical panel was designed to aid in the diagnosis of most DMGs in resource-constrained regions. Sanger sequencing was employed to identify rare EGFR mutations in exon 20 of 2 cases.ResultsMolecular analyses of 2 cases of DMG revealed novel EGFR mutations within exon 20. These mutations were identified using cost-effective diagnostic approaches. The presence of EGFR mutations expands the molecular landscape of DMGs and highlights the genetic heterogeneity within this tumor entity.ConclusionsThese findings underscore the molecular heterogeneity of DMGs and the significance of identifying novel mutations, such as EGFR mutations in exon 20. Further research into the molecular mechanisms underlying DMGs is warranted to advance therapeutic strategies and improve outcomes for pediatric patients.
An Emergent Change in Epidemiologic and Microbiological Characteristics of Bloodstream Infections in Adults With Febrile Neutropenia Resulting From Chemotherapy for Acute Leukemia and Lymphoma at Reference Centers in Chile, Ecuador, and Peru
Authors: Rabagliati Ricardo , Salazar Grace , Pérez-Lazo Giancarlo , Iturrieta Maria Paz , Portillo Diana , Soria-Segarra Carmen , Ojeda María José , Flores Jimena , Galarza Margarita , Sandoval-Ahumada Roxana , Cartes Aguilera Pablo , Dimitrakis Lady , Avelga Reinoso Fabiola , Garcia Patricia 
Published: February 2024

Abstract

Background
Febrile neutropenia is a life-threatening condition commonly observed in patients with hematologic malignancies. The aim of this article is to provide updated knowledge about bloodstream infections in febrile neutropenia episodes within the Andean region of Latin America.

Method
This retrospective study was based in 6 hospitals in Chile, Ecuador, and Peru and included adult patients with acute leukemia or lymphoma and febrile neutropenia between January 2019 and December 2020.

Results
Of the 416 febrile neutropenia episodes, 38.7% had a bloodstream infection, 86% of which were caused by gram-negative rods, with Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa being the most frequently identified bacteria. K pneumoniae isolates were more frequently resistant than E coli to cefotaxime (65% vs 39.6%), piperacillin-tazobactam (56.7% vs 27.1%), and imipenem (35% vs 2.1%) and were more frequently multidrug resistant (61.7% vs 12.5%). Among P aeruginosa, 26.7% were resistant to ceftazidime, piperacillin-tazobactam, and imipenem, and 23.3% were multidrug resistant. Overall 30-day mortality was 19.8%, being higher with vs without a bloodstream infection (26.7% vs 15.3%, P = .005). Fever duration was also significantly longer, as well as periods of neutropenia and length of hospital stay for patients with bloodstream infection. Additionally, the 30-day mortality rate was higher for episodes with inappropriate vs appropriate empirical antibiotic therapy (41.2% vs 26.6%, P = .139).

Conclusions
Considering the high rates of bacteria-resistant infection and 30-day mortality, it is imperative to establish strategies that reduce the frequency of bloodstream infections, increasing early identification of patients at higher risks of multidrug bacteria resistance, and updating existing empirical antibiotic recommendations.
Rice false smut virulence protein subverts host chitin perception and signaling at lemma and palea for floral infection
Authors: Li Guo-Bang , Liu Jie , He Jia-Xue , Li Gao-Meng , Zhao Ya-Dan , Liu Xiao-Ling , Hu Xiao-Hong , Zhang Xin , Wu Jin-Long , Shen Shuai , Liu Xin-Xian , Zhu Yong , He Feng , Gao Han , Wang He , Zhao Jing-Hao , Li Yan , Huang Fu , Huang Yan-Yan , Zhao Zhi-Xue , Zhang Ji-Wei , Zhou Shi-Xin , Ji Yun-Peng , Pu Mei , He Min , Chen Xuewei , Wang Jing , Li Weitao , Wu Xian-Jun , Ning Yuese , Sun Wenxian , Xu Zheng-Jun , Wang Wen-Ming , Fan Jing 
Published: February 2024

Abstract
The flower-infecting fungus Ustilaginoidea virens causes rice false smut, which is a severe emerging disease threatening rice (Oryza sativa) production worldwide. False smut not only reduces yield, but more importantly produces toxins on grains, posing a great threat to food safety. U. virens invades spikelets via the gap between the 2 bracts (lemma and palea) enclosing the floret and specifically infects the stamen and pistil. Molecular mechanisms for the U. virens–rice interaction are largely unknown. Here, we demonstrate that rice flowers predominantly employ chitin-triggered immunity against U. virens in the lemma and palea, rather than in the stamen and pistil. We identify a crucial U. virens virulence factor, named UvGH18.1, which carries glycoside hydrolase activity. Mechanistically, UvGH18.1 functions by binding to and hydrolyzing immune elicitor chitin and interacting with the chitin receptor CHITIN ELICITOR BINDING PROTEIN (OsCEBiP) and co-receptor CHITIN ELICITOR RECEPTOR KINASE1 (OsCERK1) to impair their chitin-induced dimerization, suppressing host immunity exerted at the lemma and palea for gaining access to the stamen and pistil. Conversely, pretreatment on spikelets with chitin induces a defense response in the lemma and palea, promoting resistance against U. virens. Collectively, our data uncover a mechanism for a U. virens virulence factor and the critical location of the host–pathogen interaction in flowers and provide a potential strategy to control rice false smut disease.