bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Auto Driller, Rig Control Systems and Driller Procedures in Reduction of BHA Failures
Authors: Barajas Pablo E. , Pastusek Paul , Lacey Aaron , Sharp Matt , Whitlow Zack , Glenn Landon , Melton Micah , Menand Stephane , Holder Bradley , Kendrick Stephen , Witt-Doerring Ysabel 
Published: October 2023

Abstract
Reducing bottom hole assembly (BHA) failures has been the focus of this operator in US land intermediate and lateral sections to reduce cost per foot. BHA failures can be mitigated with better auto driller processes, improved rig control system technology and drilling mechanics based procedures. The operator, rig contractor and BHA service providers engaged in an intensive continuous improvement process for 18 months to help two rigs in Oklahoma reduce BHA's per well. The goal was to determine how to best tune the auto driller and standardize set point practices. By investigating this for each stand drilled, the plan was to improve bit run footage and reduce BHA tool failures per hole section. The rig contractor deployed a system upgrade and adjusted driller procedures to help identify auto driller dysfunction quicker. In-bit sensors that measured drilling parameters, vibration and strain were run to validate suspected downhole dysfunction and premature bit failure.
The operator's procedure to quickly evaluate and mitigate auto driller dysfunction was trialed to distinguish rig control system induced dysfunction from downhole drilling mechanics dysfunction. For the Oklahoma rigs, auto driller stability was evaluated and improved in ∼50 BHA runs in the 12-1/4″ intermediate hole sections and in ∼100 BHA runs in the 8-3/4″ lateral BHA runs. Motor failures in the 12-1/4″ intermediate section and in the 8-3/4″ lateral sections were reduced, as were premature bit failures.
Also, it was found that tool joint hang-up in the rotating head were exciting the rig control system into dysfunction and causing a significant reduction in downhole weight on bit (WOB), differential pressure (DP) and rate of penetration (ROP). These hang-up events were occurring 3 times per stand, and although ROP would recover after the tool joint exited the rotating head, damaging vibrations at the bit continued long after the ROP recovered. The operator's tool joint compensation procedure was implemented in subsequent runs and lateral bit vibration and dull condition improved substantially.
The learnings from the auto driller continuous improvement process were cascaded to two additional rigs in another basin in East Texas. Reducing depth of cut (DOC) variance through ROP set point management in interbedded formations reduced required bit runs in the second basin as well.
The rig contractor deployed an upgraded auto driller system to minimize parameter variance and extend the life motors in high temperature laterals reducing the risk of catastrophic failure. And the rig contractor and operator continue to develop and trial auto driller dysfunction alarms to alert to possible BHA dysfunction. New tools, processes and scorecards are being developed to aid in the identification of dysfunction in rotary and slide drilling.
Transport and Plugging Performance Evaluation of a Novel Re-Crosslinkable Microgel Used for Conformance Control in Mature Oilfields with Super-Permeable Channels
Authors: Alotibi Adel , Song T. , Bai Baojun , Schuman T. P. 
Published: October 2023

Abstract
Preformed particle gels (PPG) have been widely applied in oilfields to control excessive water production. However, PPG has limited success in treating opening features because the particles can be flushed readily during post-water flooding. We have developed a novel micro-sized Re-crosslinkable PPG (micro-RPPG) to solve the problem. The microgel can re-crosslink to form a bulk gel, avoiding being washed out easily. This paper evaluates the novel microgels’ transport and plugging performance through super-permeable channels. Micro-RPPG was synthesized and evaluated for this study. Its storage moduli after fully swelling are approximately 82 Pa. The microgel characterization, self-healing process, transportation behavior, and plugging performance were investigated. A sandpack model with multi-pressure taps was utilized to assess the microgel dispersions’ transport behavior and plugging efficiency. In addition, micro-optical visualization of the gel particles was deployed to study the particle size changes before and after the swelling process. Tube tests showed that micro-RPPG could be dispersed and remain as separate particles in water with a concentration below 8,000 ppm, which is a favorable concentration for gel treatment. However, during the flooding test, the amount of microgel can be entrapped in the sandpack, resulting in a higher microgel concentration (higher than 8,000 ppm), endowing the gel particles with re-crosslinking ability even with excessive water. The microgel could propagate through the sandpack model, and the required pressure gradient mainly depends on the average particle/pore ratio and gel concentration. The gel dispersion significantly reduced channel permeability, providing sufficient resistance to post-water flooding (more than 99.97 % permeability reduction). In addition, the evaluation of micro-RPPG retention revealed that it is primarily affected by both gel concentration particle/pore ratios. We have demonstrated that the novel re-crosslinkable microgel can transport through large channels, but it can provide effective plugging due to its unique re-crosslinking property. However, by this property, the new microgel exhibits enhanced stability and demonstrates resistance to being flushed out in such high-permeability environments. Furthermore, with the help of novel technology, it is possible to overcome the inherited problems commonly associated with in-situ gel treatments, including chromatographic issues, low-quality control, and shearing degradation.
Unleashing Excellence: Using a Project Management Approach to Effectively Implement a Simulation Curriculum to Improve Resident’s Preparedness
Authors: Claudia Ebm , Pozo Ana Carolina del , Andrea Barbarello , Giovani Poli , Brusa Stefania 
Published: October 2023

Abstract
Background:The implementation of innovative, simulation-based training programs in medical education is confronted with well-known challenges such as skepticism, limited faculty time, and financial constraints. The Harvard Project Management (PM) Theory, famous for its effectiveness in business projects, holds potential for optimizing success equally in medical education. This study aims to evaluate the effectiveness of utilizing the Harvard project approach in enhancing curriculum design success, and to further assess the impact of the improved simulation-based training curriculum on the clinical preparedness of novice residents.
Methods:Twelve residency schools from Humanitas University in Milan, Italy were asked to participate in a monthly, high-fidelity simulation curriculum. Over a 12-month period, a total of twenty-two clinical high-fidelity cases were performed, focusing on patient safety and relevant topics for first-year residents across all specialties. The study employed a four-phase implementation approach: Ideation, Scale, Execution, and Closing, using project management tools like project charters, risk management, and monitoring mechanisms to standardize processes and enhance clinical deliverables. Key elements of this new management approach included defining milestones, engaging stakeholders, enhancing accountability, aligning to institutional policies and processes, and adhering to preset timelines and budgets.
Results: A total of 395 residents participated in the monthly simulation-based events, with an average participation rate of 39 +/- 19 residents per lecture. The average rating for expected skills learned significantly improved from 5.9/10 to 8.8/10 (p=0.0001). Participants found the impact on future clinical practice (4,7/5) and teamwork (4.8/5) most useful. Faculty members positively appreciated the new organizational structure, allowing them more visibility and time saving (4,8/5). The qualitative evaluation of the implementation process emphasized the importance of structured communication, specific incentive schemes, and illustrative data analysis and presentation.
Conclusion: This project highlights the positive impact of project management in simulation-based curriculum design, emphasizing the involvement of stakeholders, faculty motivation, and effective communication. The utilization of the Harvard Project Management Approach enhances curriculum design success and improves emergency preparedness for novice residents. Future implementations can build upon these findings to further optimize medical education programs.
The minimum effective dose (MED90) of remimazolam for inhibiting responses to the insertion of a duodenoscope during ERCP
Authors: GUO Yan , Dong Shu-an , SHI Jia , CHEN Hui-rong , Liu Sha-sha , Wu Li-li , Wang Jing-hua , Zhang Li , Li Huan-xi , YU Jian-bo 
Published: October 2023

Abstract
Backgroundː Compared to midazolam, remimazolam has a faster onset and offset of hypnotic effect, as well as cardiorespiratory stability, this study aims to determine the minimum effective dose (MED90) of remimazolam to inhibit responses to insertion of a duodenoscope during ERCP.
MethodsːA dose-response study was carried out undergoing ERCP who received remimazolam-alfentanil anesthesia using 10 µg/kg of alfentanil between September 2021 and November 2021. The initial dose of remimazolam was 0.2 mg/kg. The dose was then decided based on the responses of earlier patients by exploiting the sequential ascend and descend according to a 9: 1 biased coin design. Upon failure, the dose of remimazolam was increased by 0.025 mg/kg in the next patient. When the insertion was successful, the succeeding patient was randomized to an identical dose or a dose that was lower by 0.025 mg/kg.The MED90 of remimazolam for inhibiting responses to the insertion of a duodenoscope during ERCP was calculated. Adverse events and complications of remimazolam were recorded.
ResultsːA total of 55 elderly patients (age>65) were included in the study. 45 successfully anesthetized patients, and 10 unsuccessfully. The MED90 of remimazolam was 0.300 mg/kg (95% CI = 0.287–0.320). MED95 was 0.315 (95% CI = 0.312–0.323) and MED99 was 0.323 (95% CI = 0.323–0.325). Among the patients, 9 patients developed hypotension, 2 patients developed bradycardia and 1 patient developed tachycardia, and hypoxia occurred in 2 patients.
Conclusionː A loading dose of 0.300 mg / kg of remimazolam for elderly patients undergoing ERCP can safely, effectively, and quickly induce patients to fall asleep and inhibit responses to the insertion of a duodenoscope.
Trial registration：
The study protocol was registered at ClinicalTrials.gov (NCT05053763).
Stretchable Zein-Coated Alginate Fiber for Aligning Muscle Cells to Artificially Produce Cultivated Meat
Authors: Bae hojae , Jeong Dayi , Jang Goo , Jung Woo Kyung , Park Yong Ho 
Published: October 2023

Abstract
Numerous studies have explored the cultivation of muscle cells using non-animal materials for cultivated meat production. Achieving muscle cell proliferation and alignment using 3D scaffolds made from plant-based materials remains challenging. This study introduces a technique to culture and align muscle cells using only plant-based materials, avoiding toxic chemical modifications. Zein-alginate fibers (ZA fibers) were fabricated by coating zein protein onto alginate fibers (A fibers). Zein’s excellent cell compatibility and biodegradability enable high cell adhesion and proliferation rates, and the good ductility of the ZA fibers enable a high strain rate (> 75%). We demonstrate mature and aligned myotube formation in ZA fibers, providing a simple way to align muscle cells using plant-based materials. Additionally, cultivated meat was constructed by assembling muscle, fat, and vessel fibers. This method holds promise for the future mass production of cultivated meat.
Acupuncture for perimenopausal stable angina pectoris with insomnia: A protocol for randomized, double-blind, placebo-controlled trial research
Authors: Shi Rui , Liu Zhaozheng , Meng Wenyi , Chang Liping , Lu Ruozhu , Xue Wen , Chen Xingyu , Deng Yue , Song Zhenhua 
Published: October 2023

Abstract
Background
Insomnia has emerged as a major public health issue jeopardizing human wellbeing. Furthermore, insomnia and angina arise concomitantly and exert reciprocal effects. Multiple studies suggest that perimenopausal females are more prone to experiencing both angina and insomnia, consequently substantially compromising their quality of life.Credible evidence suggests that acupuncture exerts a beneficial impact in alleviating insomnia. Nevertheless, the exhaustive investigation into the potential of acupuncture for mitigating insomnia co-occurring with stable angina in perimenopausal females remains a realm yet to be traversed in the realm of randomized controlled trials. Hence, the primary intent of this research protocol was to evaluate the effectiveness and safety profile of acupuncture when administered to perimenopausal subjects grappling with concomitant conditions of stable angina and insomnia.
Methods
This study entails a single-center, randomized, double-blind, placebo-controlled clinical trial. A total of 110 patients exhibiting insomnia concomitant with stable angina in the perimenopausal period will be enlisted and randomized to either acupuncture or sham acupuncture. Participants in both arms will undergo 30-minute sessions thrice weekly over a 12-week intervention period, with a 12-week maximum follow-up. The primary outcome measure is the Pittsburgh Sleep Quality Index(PSQI). Secondary outcomes encompass the Health-Related Quality of Life Questionnaire (SF-36), Dosage of hypnotic medications, SAP-associated evaluations (including C-reactive protein, lipoprotein-associated phospholipase A2, cardiac fatty acid-binding protein levels, and the Seattle Angina Questionnaire), the Hamilton Depression Inventory (HAMD), and the Generalized Anxiety Disorder Scale (GAD-7). Primary and secondary outcomes will be evaluated at baseline, 4 weeks, 8 weeks, 12 weeks (upon completion of the intervention), and at an additional 12-week follow-up. Any adverse events will be rigorously classified and characterized with respect to time of onset and abatement, therapeutic interventions implemented, impact on the primary morbidity, and regression.
Discussion
The current study is poised to furnish pivotal clinical data on the utility of acupuncture for stable angina with concomitant insomnia in perimenopausal women, with the findings to be propagated through academic conferences and peer-reviewed publications.
Trial registration:
TCTR20221121001. Registered 19 November 2022
Performance Indicators for effective Asset Management and Leakage Reduction in Drinking Water Infrastructures
Authors: Giustolisi Orazio , Mazzolani Gianfredi , Ciliberti Francesco Gino , Laucelli Daniele Biagio , Berardi Luigi 
Published: October 2023

Abstract
Recent regulation initiatives and the ongoing digital transition in the water sector are opening a new era in drinking water infrastructure management boosted by unprecedented funding opportunities from the post-pandemic recovery plans worldwide. These investments are not solely directed at updating equipment or replacing aging pipes, but they are geared towards enhancing the efficiency of such infrastructures. Asset management, with respect to the need of leakage reduction and control in drinking water infrastructure, is a major concern for the utilities since water loss undermines the socio-economic and environmental sustainability also with respect to energy resources. In fact, the level of water loss represents an indicator of the infrastructure’s “health” status, thus assuming importance for asset management. The effectiveness of a water loss performance indicator is a relevant issue because it guides the investment, thereby the quality of the public expenditure. The present effort aims at the detailed and scientific analysis of the effectiveness of the linear and percentage water loss indicator. The linear water loss indicator proves to be effective, because scalable, and it is the basis of novel indicator, named Asset Management Support Indicator, which can drive the quality of the expenditure for water loss reduction.
Safety and short-term efficacy of GERD patients with ineffective esophageal motility treated with RefluxStop™ device implantation – a multicentric observational study
Authors: Feka Joy , Saad Merola , Boyle Nicholas , Paireder Matthias , Kristo Ivan , Rieder Erwin , Asari Reza , Schoppmann Sebastian F. 
Published: October 2023

Abstract
Background
Gastroesophageal reflux disease (GERD) presents a general health problem with a variety of symptoms and an impairment of life quality. Conservative therapies do not offer sufficient symptom relief in up to 30% of patients. Especially in patients with GERD and ineffective esophageal motility (IEM), surgical treatment is often inevitable, due to possible side effects. RefluxStop is a new alternative anti-reflux surgery potentially reducing postoperative dysphagia rates.
Methods
In this bicentric tertiary hospital observational study consecutive patients diagnosed with PPI refractory GERD and IEM that received RefluxStop implantation were included. A first safety and efficacy evaluation including clinical examination and GERD-HRQL questionnaire was conducted.
Results
40 patients (25 male and 15 female) were included. 31 patients (77.5%) were on PPI at time of surgery, with mean acid exposure time of 8.14% ± 2.53. The median hospital stay was 3 days. Postoperative QoL improved significantly measured by GERD HRQL total score from 32.83 ± 5.08 to 6.6 ± 3.71 (p < 0.001). A 84% reduction of PPI usage (p < 0.001) was noted. 36 patients (90%) showed gone or improved symptoms and were satisfied at first follow-up. Two severe adverse events need mentioning: one postoperative slipping of the RefluxStop with need of immediate revisional operation on the first postoperative day (clavian-dindo score 3b) and one device migration with no necessary further intervention.
Conclusion
RefluxStop device implantation is safe and efficient in the short term follow up in patients with GERD and IEM. Further studies and longer follow-up are necessary to prove long-lasting positive effects.
An atypical case of anterograde type A dissection masked as Giant Cell Arteritis: Case Report
Authors: Martinez Camilo J. , Murundi Shamanth , Price Jonathan 
Published: October 2023

Abstract

Background
Acute aortic dissections are medical emergencies that necessitate prompt diagnosis. Stanford Type A aortic dissections – classically presenting with tearing chest pain – can have atypical symptoms that are only recognized upon imaging.
Case Presentation
: We present a 70-year-old female presenting to the emergency department after outpatient visits with concern for temporal arteritis. She has a significant rheumatologic history of systemic lupus erythematosus, osteoporosis, fibromyalgia, and bilateral anserine bursitis. Given her symptoms of jaw claudication, otalgia, and elevated inflammatory markers, a diagnosis of giant cell arteritis was pursued and managed with prednisone. She endorsed worsening shortness of breath in the past week, prompting evaluation for new onset congestive heart failure. A CT was obtained and a Type A dissection extending into the bilateral carotid arteries was incidentally found. She was immediately taken to the operating room for ascending and hemiarch aortic replacement. She recovered well and did not have any complications.
Conclusions
Given the growing awareness of a relationship between GCA and aortic involvement, vigilance in this population can identify complications early. Clinicians should consider further examination of long standing rheumatological patients with atypical presentations given the possibility of an undiagnosed aortic dissection.
The impact of space, host dissimilitude and environment on prokaryotic communities of golf ball sponges
Authors: Cleary Daniel FR , de Voogd Nicole J 
Published: October 2023

Abstract

Golf ball sponges are small, sometimes inconspicuous, sponges. They can be found across a range of habitats varying from perturbed and pristine coral reefs to harbours and marine lakes and from the deep sea to shallow waters. They can be difficult to distinguish in the field and have presented some problems with taxonomists lumping and splitting species due to the difficulty in defining clear species traits. In the present study, we sampled golf ball sponges from Indo-Pacific and Caribbean locations and used 16S gene amplicon sequencing to study their prokaryotic communities. We show that golf ball sponges harbour a wide variety of prokaryotic communities. Among the most prevalent operational taxonomic units (OTUs), several belonged to a range of taxa, including AqS1 and ED94, which have been associated with genes known to facilitate interactions between hosts and microbes. Certain host taxa were enriched with OTUs assigned to the SAR202 clade of Chloroflexi. Our findings show that prokaryotic dissimilarity varied as a function of space (geographical distance) and host dissimilitude. The importance of space and host dissimilitude, however, varied depending on the data transformation with host dissimilitude a more important predictor of untransformed data whereas space was a more important predictor of log-transformed data. Given that log-transformation down scales the influence of abundant taxa, we interpret these results by the tendency of closely related host organisms to host similar abundant symbiotic microorganisms whereas specimens that are distantly sampled tend to harbour less abundant prokaryotic microorganisms that mirror the characteristics of their distant environments.
Functional analysis of the Dof gene family in sugar beet root tuber development
Authors: Sun Yaqing , Zhang Yongfeng , Jian Caiyuan , Wang Tong , Cao Guoli , Li Ningning , Li Guolong , Zhang Shaoying 
Published: October 2023

Abstract

In this study, members of the BvDof transcription factor family were identified in the beet genome data (Beta vulgaris L.) Through systematic analysis, 22 BvDof family genes were found in the beet genome, and they were divided into nine groups by phylogenetic analysis. Fifteen members of the BvERF family were involved in the transition to rapid root tuber growth. There was a tandem replication during the generation of the Dof gene family in sugar beet. Bv1_zfms, Bv_ofna, Bv5_racn, and Bv6_augo may be involved in the regulation of secondary cambium development in the beet root tuber. Bv9_nood, Bv1_zfms, and Bv6_cdca may be related to the growth rate of root tubers. The results provide a reference for further elucidating the molecular mechanism of the BvDof transcription factor, which regulates the development of beet root tubers.