bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEKANISME KOPING PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS DI UNIT HEMODIALISA RSUD BANDUNG
Authors: Satria Pratama Angga , Pragholapati Andria , Nurrohman Ikhwan 
Published: February 2024

Gagal ginjal kronik merupakan gangguan renal yang progresif dan irreversible dimana kemampuan tubuh gagal mempertahankan metabolisme dan keseimbangan dan elektrolit, pasien gagal ginjal kronik harus menjalani terapi hemodialisis secara terus menerus seumur hidup dan akan menimbulkan masalah fisik dan psikologis yaitu depresi, pasien harus memiliki upaya dalam menyelesaikan masalah yang dihadapinnya yang dikenal dengan mekanisme koping. Tujuan penelitian untuk mengetahui mekanisme koping pada pasien gagal ginjal kronik yang menjalani terapi hemodialisis di unit hemodialisa Rumah Sakit Umum Daerah Kota Bandung.Metode penelitian menggunakan deskriptif kuantitatif. Sampel dalam penelitian ini menggunakan total sampling yaitu sebanyak 51 responden pasien gagal ginjal kronik yang menjalani terapi hemodialisis.Hasil penelitian mekanisme koping lebih dari setengahnya adalah mekanisme koping adaptif sebanyak 38 orang (74.5%). Berdasarkan hasil penelitian Perawat di ruang hemodialisa diharapkan dapat meningkatkan asuhan keperawatan secara menyeluruh yang bukan hanya biologisnya saja tapi pada psikologis pasien gagal ginjal kronik juga, seperti memberikan konseling sehingga pasien mampu menggunakan mekanisme koping yang adaptif. Kata Kunci: gagal ginjal; hemodialisis; mekanisme koping MECHANISM OF COPING IN CHRONIC KIDNEY FAILURE IN HEMODIALYSIS PATIENTS AT REGIONAL PUBLIC HOSPITAL OF BANDUNG ABSTRACT Chronic renal failure is a progressive and irreversible renal disorder in which the body's ability to fail to maintain metabolism and balance and electrolytes, patients with chronic renal failure must undergo continuous hemodialysis therapy for life and it will cause physical and psychological problems namely depression, patients must have the effort to resolve the problem that is facing by knowing the coping mechanism. The purpose of this study was to determine the coping mechanism in chronic kidney failure patients undergoing hemodialysis therapy in the hemodialysis unit of Regional Public Hospital of Bandung City.The research method used quantitative descriptive. The sample in this study used a total sampling of 51 respondents from chronic kidney failure patients undergoing hemodialysis therapy.The results of research on coping mechanisms more than half are adaptive coping mechanisms as many as 38 people (74.5%). Based on the results of research Nurses in the hemodialysis room are expected to improve overall nursing care that is not only biologically but also psychologically in patients with chronic kidney failure, such as providing counseling so that patients are able to use adaptive coping mechanisms. Keywords: kidney failure; hemodialysis; coping mechanism
Cardiovascular Risk Reduction in Diabetes Mellitus, Taking into Account the Updated Recommendations of the Global Initiative to Improve the Results of Treatment of Kidney Diseases
Authors: Мохорт Т.В. 
Published: February 2024

Хронические осложнения сахарного диабета, включая диабетическую болезнь почек (ДБП), определяют снижение качества и продолжительности жизни и являются предиктором смерти от кардиоваскулярной патологии. Обновленные рекомендации Глобальной инициативы по улучшению результатов лечения болезней почек определяют особенности мониторинга диабета, питания и тактики выбора антигипергликемической терапии. Современные походы основаны на выборе лекарственных средств, обеспечивающих низкий риск гипогликемических реакций, снижение кардиоваскулярных рисков и нефропротективное влияние. Также отражены инновационные походы, направленные на замедление развития почечного фиброза, основой которого является блокада альдостерона с использованием антагонистов минералокортикоидных рецепторов, включая финеренон.
Chronic complications of diabetes, including diabetic kidney disease, determine a decrease in the quality and duration of life and are a predictor of death from cardio-vascular pathology. The updated recommendations of the Global initiative to improve the results of treatment of kidney diseases determine the features of diabetes monitoring, nutrition and tactics of choosing antihyperglycemic therapy. Modern campaigns are based on the choice of medicines that provide a low risk of hypoglycemic reactions, reduction of cardio-vascular risks and nephroprotective effect. Innovative campaigns aimed at slowing the development of renal fibrosis, which is based on the blockade of aldosterone with the use of mineralocorticoid receptor antagonists, including finerenone, are also reflected.
Cardiac Involvement in High-Grade B-cell Lymphoma: A Case Report
Authors: Кондратьев Ф.В. , Зарадей И.И. , Гайшун Е.И. , Калыхан Д.М. , Булгак А.Г. , Пристром А.М. 
Published: February 2024

Поражение сердца при лимфопролиферативных заболеваниях встречается, по данным аутопсий, в 8,7–20% случаев. Прижизненная диагностика данной патологии затруднена. В большинстве случаев поражение сердца носит вторичный характер, в то время как первичное составляет 0,25–2,1% всех опухолей данной локализации. Самой распространенной группой лимфопролиферативных заболеваний являются диффузные крупноклеточные B-клеточные лимфомы, а одной из редких и агрессивных групп – крупноклеточные B-клеточные лимфомы высокой степени злокачественности. C помощью трансторакальной эхокардиографии новообразования сердца диагностируются примерно в 60% случаев, при использовании чреспищеводной эхокардиографии – более чем в 90% случаев. Наиболее информативным неинвазивным методом является позитронно-эмиссионная томография / компьютерная или магнитно-резонансная томография всего тела с использованием 18F-фтордезоксиглюкозы. Верифицируется диагноз гистологическими, иммуногистохимическими, молекулярно-генотипическими методами. Поскольку опухоли сердца в клинической практике встречаются достаточно редко, каждый случай по-своему уникальный и должен тщательно изучаться.
Heart damage in lymphoproliferative diseases occurs, according to autopsies, in 8.7–20% of cases. During life, the percentage of diagnosis is significantly lower. In most cases, heart damage in is secondary, while primary heart damage occurs in 0.25–2.1% of all primary tumors of this localization. The most common group of lymphoproliferative diseases are diffuse B-cell lymphomas, and one of their rarest and most aggressive group is high-grade B-cell lymphoma. With the help of transthoracic echocardiography, neoplasms of the heart are diagnosed in about 60% of cases, with the use of transesophageal echocardiography – in more than 90% of cases. The most informative non-invasive method is positron emission tomography / computer or magnetic resonance imaging of the whole body using 18F-fluorodeoxyglucose. The diagnosis is verified by histological, immunohistochemical, molecular genotypic methods. Since heart tumors are rarely found in clinical practice, each case is unique in its own way and should be carefully studied.
ANALISIS SEMIOTIK TOKOH WEI ZHONGXIAN DALAM FILM BROTHERHOOD OF BLADES
Authors: Wibiyanto Agung , Syaifullah Jahid , Sukendar Markus Utomo 
Published: February 2024

Wei Zhongxian merupakan tokoh sejarah orang nomer dua setelah kaisar Tianqi secara nyata yang hidup di akhir kekaisaran Ming berhasil difilmkan di dalam film Brotherhood of Blades sebagai tokoh antagonis, di mana tergolong sebagai tokoh yang culas, manipulatif dan juga korupsi. Oleh sebab itu di dalam artikel ini akan mengulas semiotika tokoh Wei Zhongxian dalam beberapa scene di film Brotherhood of Blades. Metode yang digunakan ialah metode kualitatif dengan analisis deskriptif dengan mengambil sumber di dalam beberapa scene tokoh Wei Zhongxian di film Brotherhood of Blades. Dalam membedah tokoh Wei Zhongxian dalam film ini terdiri dari dua aspek denotasi, di mana untuk aspek denotasi di masing masing scene yang didapatkan dapat dirumuskan bahwa Wei Zhongxian masih mempunyai pengaruh yang cukup kuat di dalam jajaran Jinyiwei/pasukan pelindung Kaisar Ming sehingga cukup sulit untuk menyingkirkan dirinya dan juga jaringannya di dalam tubuh pemerintahan. Sedangkan untuk aspek konotasinya, dapat dirumuskan bahwa walaupun Wei Zhongxian sudah tersingkir dalam tubuh pemerintahan, dia mampu memainkan perannya sebagai seorang politisi handal, di mana dapat disimbolkan dalam film ini dengan kekayaan materinya dan dadu sebagai simbolik dari permainan yang dia ciptakan.Kata Kunci: Wei Zhongxian, analisis semiotik, film Brotherhood of Blades
Edukasi Pencegahan Hipertensi Dengan “Health Belief Model-Cerdik” Pada Masyarakat Di Wilayah Pesisir Desa Rugemuk Kecamatan Pantai Labu
Authors: Syaftriani Afina Muharani 
Published: February 2024

Penyakit tekanan darah tinggi salah satu penyebab ancaman penduduk di daerah pantai, seperti Kecamatan Pantai Labu khususnya Desa Rugemuk. Hipertensi pada wilayah pantai di Rugemuk mencapai 30%. Beberapa cara dalam mengurangi akibat tekanan darah tinggi adalah dengan meningkatkan upaya promotif dan preventif dari penyakit hipertensi. Health Belief Model (HBM) adalah upaya promotif untuk mengubaah tingkah laku seseorang yang didasarkan pada pemahamannya. Edukasi Health Belief Model efektif dalam meningkatkan perilaku preventif maupun pengetahuan pasien terkait penyakitnya. PKM ini bertujuan sebagai pemberian materi dalam mengurangi Hipertensi dengan Health Belief Model-Cerdik pada penduduk Wilayah Pesisir Rugemuk. Kegiatan PKM akan dilakukan dengan edukasi/ penyuluhan. Sasaran pelaksanaan kegiatan merupakan penduduk Wilayah Pesisir Desa Rugemuk Kecamatan Pantai Labu. Hasil pengabdian masyarakat ini Masyarakat dapat menambah pengetahuan dan keterampilannya dalam Pencegahan Penyakit Hipertensi dengan metode “CERDIK (Cek kesehatan secara rutin, Enyahkan kafein, alkohol asap rokok, Rajin aktivitas fisik, Diet seimbang dengan mengurangi makanan yang mengandung lemak tinggi, tinggi kalori, berminyak, kolestrol, santan, garam berlebihan dan penggunaan kadar gula tinggi, Istirahat cukup, Kelola stress)”. Disarankan bagi masyarakat di di Wilayah Pesisir Desa Rugemuk Kecamatan Pantai Labu untuk selalu menjaga pola hidup sehat yang diawali dengan konsumsi nutrisi yang cukup agar terhindar dari hipertensi, sehingga tercipta masyarakat sehat bebas hipertensi.
Gill morphometrics of freshwater Tilapia zillii as an indicator of fish welfare
Authors: Jenjan Dr. Hussein B , Farag , Fathe Ben-Ali , Ben ahmeid Asma. A 
Published: February 2024

Tilapia zillii was used to examine the effect of environment on gill morphometric therefore to discover the probability of using gill morphometrics to measure welfare in wild fish. Thirty mature Tilapia zillii was collected from Lagoon of Ain-Ziyana in eastern of Benghazi city and the sizes of their gills were estimated. The gill respiratory surface area of Tilapia zillii reached from 851.31 mm² to 1929.32 mm² ̸ g of body weight. The connection among gill respiratory surface area and fish body weight was found to be highly significant (P= 0.001). The gill respiratory surface area of Tilapia zillii rise as the fish grows this may be since the gill filaments number, the secondary lamellae number and the surface area of secondary lamellae increases. Great gill surface area might support survival of Tilapia fish in oxygen-stressed. This recommends that the measure developed here could be possibly used as an guide of welfare in wild fish.
السِّياسة الخارجيَّة الأوروبيَّة المُشتركة: ملامحُ الواقع وتحدِّياتُ المُستقبل
Authors: السحاتي أ.خالد خميس , الدرسي أ. خالد صـالــح , الفيتوري أ. نـوال بالعيد سالم 
Published: February 2024

تناولنا في هذه الدراسة موضوع: "السِّياسة الخارجيَّة الأوروبيَّة المُشتركة: ملامحُ الواقع وتحدِّياتُ المُستقبل"، من خلال خمسة محاور رئيسة هي: المحور الأول: تـأسيـسُ "الاتحـــاد الأوروبي"، الثاني: السِّياسةُ الخارجيَّةُ الأوروبيَّةُ المُشتركةُ: لمْحةٌ عامَّةٌ، الثالث: أهـدافُ السِّياسة الخارجيَّة الأوروبيَّة المُشتركة، الرابع: آليَّـاتُ السِّيـاسة الخـارجيَّة الأوروبيَّة المُشتركـة، الخامس: أبرزُ التَّحدِّياتُ التي تُعيقُ من تحقيق السِّياسة الخارجيَّة المُشتركة للاتحاد الأوروبي. وتم التركيز على أبرز التحديات الداخلية والخارجية، فالأولى أبرزها عشرة تحديات: إشكالية الانسجام السياسي، الخلافاتُ المُتعلقة بالسِّيادة الوطنيَّة، الخلافاتُ والانقساماتُ الأوروبيَّة نتيجة تبايُن المصالح، رفضُ الدستُور الأوروبيِّ، إشكاليَّاتُ ميزانيَّة الاتِّحاد الأورُوبيِّ ومُخصَّصاتُ السِّياسة الخارجيَّة المُشتركة، مسألة اختلاف الثقافات في أوروبا، "التوسُّعُ الجديدُ" انضمامُ دُولٍ أُخْرى لعُضويَّة "الاتِّحاد الأوروبيِّ"، مسارُ صُنع القرار وإشكاليَّاته، تزايد حالة التشكيك في الاتحاد الأوروبي، وأخيرا الحربُ الرُّوسيَّة-الأوكرانيَّة في أوروبا. أما أبرز التحديات الخارجية: الوزنُ السِّياسيُّ المحدُود لأوروبا في النِّظام الدَّوليِّ، العـلاقـة مع الولايات المتحـدة الأمريكية، استمـرار نفـوذ الاتحاد الأوروبي على الساحة الدولية.
إن ما يمكن استخلاصه من خلال هذه الدراسة، هو أن الاتحاد الأوروبي كتكتل إقليمي قد نجح في تحقيق التكامل الاقتصادي الذي ولد الرغبة في مواصلة مسيرة التكامل والانتقال من التكامل الاقتصادي إلى الرغبة في تحقيق التكامل السياسي المتمثل في توحيد السياسة الخارجية والأمنية المشتركة، فمنذ نهاية الحرب الباردة، وانهيار الاتحاد السوفيتي وظهور تحديات تشكل خطرا على الأمن الأوروبي تزايدت التوجهات الأوروبية نحو التفكير في صياغة سياسة خارجيَّة وأمنيَّة مُشتركة. إن الضعف في السياسة الخارجية للاتحاد الأوروبي راجع إلى انقسام دول الاتحاد في تحديد مفهوم دقيق للسياسة الخارجية والأمنية المشتركة، وكذلك اختلاف خصائص الدول وثقافتها السياسية، وعلاقات بعض دول الاتحاد الأوروبي مع الولايات المتحدة الأمريكية. والاستراتيجيَّة التي يُعوَّلُ عليها لتحقيق فاعليَّةٍ وتقدُّمٍ في السِّياسة الخارجيَّة المُشتركة هي الإرادةُ السِّياسيَّةُ القويَّة، التي يستطيعُ من خلالها الاتحادُ الأوروبيُّ الوُقُوف على أرضٍ صُلبةٍ، وتعزيز قُوَّته السِّياسيَّة في المجتمع الدولي.
Evaluating the Appropriateness of Learner-centered Education in Higher Education
Authors: Masaud Mohamed Mabrouk 
Published: February 2024

This study aims at introducing learner-centered education as an alternative to the conventional education that exists in higher education institutions in Libyan universities. The assumption is that the didactic teaching hinders learners from participating effectively in the learning process. The study will explore possible obstacles and factors that influence the learning situation. Possible ways to improve the situation will be suggested. This will include adopting the ways of learning which encourage learners to be active participants rather than recipient of knowledge. This study is an attempt to introduce the learner-centered approach to both teachers and learners. It is hoped that it will be possible to replace the strict teacher-centered approach to learning which prevail in Libyan universities with the suggested approach. The ultimate goal is to encourage learners to be themselves, and to learn by themselves instead of passively regurgitate information remembered from lectures. By the end of the study, some suggestions are introduced in an attempt to encourage both university teachers and students to adopt the learner-centered education. This of course necessitate the modification of both teachers and learners roles in the learning process.
The role of TrkB receptor signaling in Alzheimer’s disease
Authors: He Kaiwu , Nie Lulin , Dai Zhongliang , Li Shupeng , Yang Xifei , Liu Gongping 
Published: February 2024

Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders among the elderly. However, there is no reliable drug for the treatment of AD, which is largely due to the unknown mechanisms and the lack of credible drug targets. Some studies demonstrated the hat the brain-derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) signaling pathway may be a potential therapeutic target for AD. As the most widely studied neurotrophin in the brain, BDNF has a high affinity for TrkB receptor and plays an important role in the regulation of neuronal survival, growth, and synaptic plasticity. Mechanistically, TrkB signaling cascade is considered to be the most important way in which BDNF exerts neuroprotective effects. The expression of TrkB receptor was also found to be significantly decreased in AD patients and AD animals compared with the control, suggesting the involvement of TrkB receptor and TrkB-dependent signal in AD pathogenesis. In this review, we aim to discuss the possible role of TrkB-dependent signal in AD pathogenesis, focusing on three major downstream pathways including phosphatidylinositol-3 kinase/protein kinase B (PI3K/AKT), extracellular regulated kinase (ERK), and phospholipase C-γ1 (PLC-γ1) pathways.
Dynamical Architectures of S-type Transiting Planets in Binaries. I. Target Selection Using Hipparcos and Gaia Proper Motion Anomalies*
Authors: Zhang 张 Jingwen 婧雯 , Weiss Lauren M. , Huber Daniel , Jensen Eric L. N. , Brandt Timothy D. , Collins Karen , Conti Dennis M. , Isaacson Howard , Lewin Pablo , Marino Giuseppe , Massey Bob , Murgas Felipe , Palle Enric , Radford Don J. , Relles Howard M. , Srdoc Gregor , Stockdale Chris , Tan Thiam-Guan , Wang Gavin 
Published: February 2024

Abstract
The effect of stellar multiplicity on planetary architecture and orbital dynamics provides an important context for exoplanet demographics. We present a volume-limited catalog of up to 300 pc of 66 stars hosting planets and planet candidates from Kepler, K2, and TESS with significant Hipparcos-Gaia proper motion anomalies, which indicates the presence of companions. We assess the reliability of each transiting planet candidate using ground-based follow-up observations, and find that the TESS Objects of Interest (TOIs) with significant proper anomalies show nearly four times more false positives due to eclipsing binaries compared to TOIs with marginal proper anomalies. In addition, we find tentative evidence that orbital periods of planets orbiting TOIs with significant proper anomalies are shorter than those orbiting TOIs without significant proper anomalies, consistent with the scenario that stellar companions can truncate planet-forming disks. Furthermore, TOIs with significant proper anomalies exhibit lower Gaia differential velocities in comparison to field stars with significant proper anomalies, suggesting that planets are more likely to form in binary systems with low-mass substellar companions or stellar companions at wider separation. Finally, we characterize the three-dimensional architecture of LTT 1445 ABC using radial velocities, absolute astrometry from Gaia and Hipparcos, and relative astrometry from imaging. Our analysis reveals that LTT 1445 is a nearly flat system, with a mutual inclination of ∼2.°88 between the orbit of BC around A and that of C around B. This coplanarity may explain why multiple planets around LTT 1445 A survive in the dynamically hostile environments of this system.
Illuminating the Dark Side of Cosmic Star Formation. III. Building the Largest Homogeneous Sample of Radio-selected Dusty Star-forming Galaxies in COSMOS with PhoEBO
Authors: Gentile Fabrizio , Talia Margherita , Behiri Meriem , Zamorani Giovanni , Barchiesi Luigi , Vignali Cristian , Pozzi Francesca , Bethermin Matthieu , Enia Andrea , Faisst Andreas L. , Giulietti Marika , Gruppioni Carlotta , Lapi Andrea , Massardi Marcella , Smolčić Vernesa , Vaccari Mattia , Cimatti Andrea 
Published: February 2024

Abstract
In the last decades, an increasing scientific interest has been growing in the elusive population of dark (i.e., lacking an optical/near-IR, hereafter NIR, counterpart) dusty star-forming galaxies (DSFGs). Although extremely promising for their likely contribution to the cosmic star formation rate density (SFRD) and for their possible role in the evolution of the first massive and passive galaxies around z ∼ 3, the difficulty in selecting statistically significant samples of dark DSFGs is limiting their scientific potentialities. This work presents the first panchromatic study of a sample of 263 radio-selected NIR-dark (RS-NIRdark) galaxies discovered in the COSMOS field following the procedure by Talia et al. These sources are selected as radio-bright galaxies (S
3 GHz > 12.65 μJy) with no counterpart in the NIR-selected COSMOS2020 catalog (Ks ≳ 25.5 mag). For these sources, we build a new photometric catalog including accurate photometry from the optical to the radio obtained with a new deblending pipeline (Photometry Extractor for Blended Objects, or PhoEBO). We employ this catalog to estimate the photo-zs and the physical properties of the galaxies through an spectral energy distribution-fitting procedure performed with two different codes (Magphys and Cigale). Finally, we estimate the active galactic nucleus contamination in our sample by performing a series of complementary tests. The high values of the median extinction (A

v
∼ 4) and star formation rate (SFR ∼ 500 M
⊙ yr−1) confirm the likely DSFG nature of the RS-NIRdark galaxies. The median photo-z (z ∼ 3) and the presence of a significant tail of high-z candidates (z > 4.5) suggest that these sources are important contributors to the cosmic SFRD and the evolutionary path of galaxies at high redshifts.
Zero and Extremely Low-metallicity Rotating Massive Stars: Evolution, Explosion, and Nucleosynthesis Up to the Heaviest Nuclei
Authors: Roberti Lorenzo , Limongi Marco , Chieffi Alessandro 
Published: February 2024

Abstract
We present the evolution and the explosion of two massive stars, 15 and 25 M
⊙, spanning a wide range of initial rotation velocities (from 0 to 800 km s−1) and three initial metallicities: Z = 0 ([Fe/H] = −∞), 3.236 × 10−7 ([Fe/H] = −5), and 3.236 × 10−6 ([Fe/H] = −4). A very large nuclear network of 524 nuclear species extending up to Bi has been adopted. Our main findings may be summarized as follows: (a) rotating models above Z = 0 are able to produce nuclei up to the neutron closure shell N = 50, and in a few cases up to N = 82; (b) rotation drastically inhibits the penetration of the He convective shell in the H-rich mantle, a phenomenon often found in zero metallicity nonrotating massive stars; (c) vice versa, rotation favors the penetration of the O convective shell in the C-rich layers with the consequence of significantly altering the yields of the products of the C, Ne, and O burning; (d) none of the models that reach the critical velocity while in H burning lose more the 1 M
⊙ in this phase; (e) conversely, almost all models able to reach their Hayashi track exceed the Eddington luminosity and dynamically lose almost all their H-rich mantle. These models suggest that rotating massive stars may have contributed significantly to the synthesis of the heavy nuclei in the first phase of enrichment of the interstellar medium, i.e., at early times.
A note on the $H^{s}$-critical inhomogeneous nonlinear Schrödinger equation
Authors: An JinMyong , Kim JinMyong 
Published: February 2024

In this paper, we consider the Cauchy problem for the

H^{s}

-critical inhomogeneous nonlinear Schrödinger (INLS) equation

iu_{t} +\Delta u=\lvert{x}\rvert^{-b}f(u),\quad u(0)=u_{0} \in H^{s} (\mathbb{R}^{n}),

where

n\in \mathbb{N}

,

0\le s<\smash{\frac{n}{2}}

,

0<b<\min\{2, n-s, 1+\smash{\frac{n-2s}{2}}\}

and

f(u)

is a nonlinear function that behaves like

\lambda \lvert{u}\rvert^{\sigma}u

with

\lambda \in \mathbb{C}

and

\sigma=\smash{\frac{4-2b}{n-2s}}

. First, we establish the local well-posedness as well as the small data global well-posedness in

H^{s}(\mathbb{R}^{n})

for the

H^{s}

-critical INLS equation by using the contraction mapping principle based on the Strichartz estimates in Sobolev–Lorentz spaces. Next, we obtain some standard continuous dependence results for the

H^{s}

-critical INLS equation. Our results about the well-posedness and standard continuous dependence for the

H^{s}

-critical INLS equation improve the ones of Aloui–Tayachi [Discrete Contin. Dyn. Syst. 41 (2021), 5409–5437] and An–Kim [Evol. Equ. Control Theory 12 (2023), 1039–1055] by extending the validity of

s

and

b

. Based on the local well-posedness in

H^{1}(\mathbb{R}^{n})

, we finally establish the blow-up criteria for

H^{1}

-solutions to the focusing energy-critical INLS equation. In particular, we prove the finite time blow-up for finite-variance, radially symmetric or cylindrically symmetric initial data.