bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of early hospital readmission after kidney transplantation: Perspectives from a Canadian transplant centre
Authors: Famure Olusegun , Kim Esther D. , Li Yanhong , Huang Johnny W. , Zyla Roman , Au Magdalene , Chen Pei Xuan , Sultan Heebah , Ashwin Monika , Minkovich Michelle , Kim S Joseph 
Published: December 2023

BACKGROUND
Early hospital readmissions (EHRs) after kidney transplantation range in incidence from 18%-47% and are important and substantial healthcare quality indicators. EHR can adversely impact clinical outcomes such as graft function and patient mortality as well as healthcare costs. EHRs have been extensively studied in American healthcare systems, but these associations have not been explored within a Canadian setting. Due to significant differences in the delivery of healthcare and patient outcomes, results from American studies cannot be readily applicable to Canadian populations. A better understanding of EHR can facilitate improved discharge planning and long-term outpatient management post kidney transplant.
AIM
To explore the burden of EHR on kidney transplant recipients (KTRs) and the Canadian healthcare system in a large transplant centre.
METHODS
This single centre cohort study included 1564 KTRs recruited from January 1, 2009 to December 31, 2017, with a 1-year follow-up. We defined EHR as hospitalizations within 30 d or 90 d of transplant discharge, excluding elective procedures. Multivariable Cox and linear regression models were used to examine EHR, late hospital readmissions (defined as hospitalizations within 31-365 d for 30-d EHR and within 91-365 d for 90-d EHR), and outcomes including graft function and patient mortality.
RESULTS
In this study, 307 (22.4%) and 394 (29.6%) KTRs had 30-d and 90-d EHRs, respectively. Factors such as having previous cases of rejection, being transplanted in more recent years, having a longer duration of dialysis pretransplant, and having an expanded criteria donor were associated with EHR post-transplant. The cumulative probability of death censored graft failure, as well as total graft failure, was higher among the 90-d EHR group as compared to patients with no EHR. While multivariable models found no significant association between EHR and patient mortality, patients with EHR were at an increased risk of late hospital readmissions, poorer kidney function throughout the 1st year post-transplant, and higher hospital-based care costs within the 1st year of follow-up.
CONCLUSION
EHRs are associated with suboptimal outcomes after kidney transplant and increased financial burden on the healthcare system. The results warrant the need for effective strategies to reduce post-transplant EHR.
Dosing strategies for de novo once-daily extended release tacrolimus in kidney transplant recipients based on CYP3A5 genotype
Authors: Diamond Adam , Karhadkar Sunil , Chavin Kenneth , Constantinescu Serban , Lau Kwan N. , Perez-Leal Oscar , Mohrien Kerry , Sifontis Nicole , Di Carlo Antonio 
Published: December 2023

BACKGROUND
Tacrolimus extended-release tablets have been Food and Drug Administration-approved for use in the de novo kidney transplant population. Dosing requirements often vary for tacrolimus based on several factors including variation in metabolism based on CYP3A5 expression. Patients who express CYP3A5 often require higher dosing of immediate-release tacrolimus, but this has not been established for tacrolimus extended-release tablets in the de novo setting.
AIM
To obtain target trough concentrations of extended-release tacrolimus in de novo kidney transplant recipients according to CYP3A5 genotype.
METHODS
Single-arm, prospective, single-center, open-label, observational study (ClinicalTrials.gov: NCT03713645). Life cycle pharma tacrolimus (LCPT) orally once daily at a starting dose of 0.13 mg/kg/day based on actual body weight. If weight is more than 120% of ideal body weight, an adjusted body weight was used. LCPT dose was adjusted to maintain tacrolimus trough concentrations of 8-10 ng/mL. Pharmacogenetic analysis of CYP3A5 genotype was performed at study conclusion.
RESULTS
Mean time to therapeutic tacrolimus trough concentration was longer in CYP3A5 intermediate and extensive metabolizers vs. CYP3A5 non-expressers (6 d vs. 13.5 d vs. 4.5 d; P = 0.025). Mean tacrolimus doses and weight-based doses to achieve therapeutic concentration were higher in CYP3A5 intermediate and extensive metabolizers vs. CYP3A5 non-expressers (16 mg vs. 16 mg vs. 12 mg; P = 0.010) (0.20 mg/kg vs. 0.19 mg/kg vs. 0.13 mg/kg; P = 0.018). CYP3A5 extensive metabolizers experienced lower mean tacrolimus trough concentrations throughout the study period compared to CYP3A5 intermediate metabolizers and non-expressers (7.98 ng/mL vs. 9.18 ng/mL vs. 10.78 ng/mL; P = 0 0.008). No differences were identified with regards to kidney graft function at 30-d post-transplant. Serious adverse events were reported for 13 (36%) patients.
CONCLUSION
Expression of CYP3A5 leads to higher starting doses and incremental dosage titration of extended-release tacrolimus to achieve target trough concentrations. We suggest a higher starting dose of 0.2 mg/kg/d for CYP3A5 expressers.
Digital Entrepreneurship as One of The Applications of Contemporary Administration in The Entrepreneurial Orientations
Authors: Alkasassbeh Wasfi Abdul Kareem 
Published: December 2023

Purpose: The objective of this research was to investigate how Digital entrepreneurship influences the achievement of entrepreneurial orientations within communication companies located in Tabuk region. To attain these goal, the researcher adopted an analytical descriptive approach and utilized a questionnaire as the primary tool for collecting data.

Theoretical framework: The theoretical basis is the literature on Digital Entrepreneurship and the Entrepreneurial Orientations.

Design/methodology/approach: Data was gathered quantitativel The study involved study consisted of all Zain communication companies in Tabukwith a total of (6) branches, Mobilycompany with its (5) branches, and STC company with its branches its (5), where the total number of employees was (180).

Findings: According to the findings, indicate that the findings indicated that the overall average scores for both Digital entrepreneurship and entrepreneurial orientations were notably high. Furthermore, the results highlighted a statistically significant relationship between Digital entrepreneurship and its various dimensions, and the attainment of entrepreneurial orientations. Specifically, the variables that had a significant impact on entrepreneurial orientations were innovation and creativity, digital knowledge base, and the digital business environment.

Research, Practical & Social Implications: This study examines digital entrepreneurship as a crucial aspect of modern administration in entrepreneurial contexts. It explores the intricate facets of digital entrepreneurship, uncovering its implications for research, practical applications, and societal impact. Through a detailed analysis of the dynamic relationship between administration and entrepreneurial orientations in the digital realm, the research aims to provide valuable contributions to both academic knowledge and Different sectors.

Originality/value: The study's worth lies in the additional insights it gives into the rising Digital Entrepreneurship as one of the Applications of Contemporary Administration in the Entrepreneurial Orientations.
Local Public Broadcasting Institutions and Digital Literacy in Distance Learning Activities
Authors: Sjuchro Dian Wardiana , Rusmana Agus , Sjafirah Nuryah Asri , Lusiana Elnovani , Sujana Lusi Romaddyniah 
Published: December 2023

Purpose: This study aimed to examine digital literacy practice by utilizing the Local Public Broadcasting Institution in Distance Learning activities with a qualitative descriptive approach.

Theoretical Framework: Local Public Broadcasting Institutions contribute as a means of digital literacy in Distance Learning online activities (using internet channels) often encounter constraints and obstacles. Local Public Broadcasting Institutions is present as a solution that facilitates digital distance learning literacy through radio channels.

Result: The study results show the effectiveness of radio as part of the Local Public Broadcasting Institutions platform in supporting digital literacy in Distance Learning.

Conclusion: Local Public Broadcasting Institutions through a digital literacy program based on a broadcast radio platform, is proven to provide solutions in the field of Distance Learning, facilitating digital literacy for the public to develop the ability to use information and communication technology, obtain information, evaluate, create, and communicate the information obtained.
The Regulations of The Law Concerning Hate Speech Offenses
Authors: Kurniawan  , Judhariksawan  , Sampurno Slamet , Maskun  
Published: December 2023

Objective: This research aims to examine the legal regulations of hate speech crimes in the ITE Law and the Indonesian Criminal Code (KUHP), and further explore the resolution of hate speech conflicts.

Theoretical Framework: The theoretical foundations include Legal Certainty theory, Law Enforcement theory, and Legal Convergence theory concerning hate speech conflict resolution following the principle of legal certainty.

Method: This study employs a qualitative normative approach (doctrinal) utilizing various legal instruments and indirect observation through conceptual, historical, legal, comparative, and case study approaches. Data collection involves literature review and field research through interviews. The data are analyzed qualitatively, generating descriptive data to reveal legal issues.

Findings and Conclusion: The main findings indicate that Article 28 paragraph (2) of the ITE Law still leads to multiple interpretations. The absence of the term "incitement" allows subjective interpretation and constitutes a very broad formulation. A comparison of hate speech crimes in Article 28 Paragraph (2) Jo Article 45A Paragraph (2) of the ITE Law with Article 243 Paragraph (1) and Paragraph (2) of the new Indonesian Criminal Code shows significant differences in terms of elements of the crime, general criminal law principles, additional penalties, lower/proportional sanctions, public virtual domain, integrated codification, and expanded meanings.

Originality/Value: This paper recommends urging the government to refine hate speech regulations to prevent multiple interpretations and emphasizes the need for guidelines in law enforcement application.
A Study of Customers Knowledge and Satisfaction with Ott Platforms
Authors: Varalakshmi Chadalavada , Rani Padala Lalitha , Srividya Godmala , Beig Naim , Pradeep Gowthu Suresh 
Published: December 2023

Purpose: The main objective of this study is to find out how well users are aware of OTT platforms and how satisfied they are with their utilization of OTT platforms. It investigated at how demographic characteristics like gender, age, occupation, educational attainment, marital status, income level, and region affect users' awareness of and enjoyment with OTT platforms.

Theoretical framework: There is little empirical data available to assess user satisfaction and awareness of OTT platforms. OTT platforms have become quite common and many people have begun to use them due to their low cost and ease of usage.

Design/Methodology/Approach: An assessment of the survey of literature utilized by the research design. A data collecting tool, such as a questionnaire, and a non-probability sampling approach, such as the Snow ball sampling technique, are employed. To collect data, a standard questionnaire is employed. The data was gathered from respondents in the Andhra Pradesh state's West Godavari area.

Findings: Various statistical approaches, such as comparison of means, ANOVA, and regression, are employed to analyze the data. User satisfaction and degree of awareness were assessed by taking demographic factors into account. The age, occupation, marital status, and amount of income of OTT platform users all have a statistically significant association with their level of satisfaction. The user's gender, educational level, and geography have no statistically significant impact on their degree of satisfaction with OTT platforms. The user's age is statistically significant in terms of their awareness of the use of OTT platforms. Gender, occupation, educational level, marital status, income level, and location are statistically insignificant factors in OTT platform knowledge.

Research, Practical &social implication: This study evaluated the user’s level of awareness and satisfaction with the using OTT platforms.

Originality/Value: The goal of this study is to identify and evaluate the impact of various demographical characteristics on users' level of understanding and contentment with OTT platforms.
Economic Aspects of Pilgrimages of The People of Central Asia (1500-1860)
Authors: Tanieva Guldona M. , Zakhidova Sakhovat A. , Khamidova Mukhabbat S. 
Published: December 2023

Objectives: In this section, the primary goals of the article are outlined. The focus is on identifying and understanding the key objectives that the author aims to achieve through their scientific analysis of pilgrimage travel from Central Asia to Mecca during the first half of the XVI-XIX centuries.

Methods: Here, the methods employed by the author in conducting their research are detailed. This includes a description of the sources utilized, such as writings by Central Asian authors, travelogues of foreign tourists, and information extracted from the archives of Uzbekistan, Turkey, and Russia. The methods section provides insight into the research process and the tools used to gather and analyze data.

Results: This section presents the outcomes of the scientific analysis, revealing the findings derived from the author's examination of pilgrimage travel from Central Asia to Mecca. It may include information on the economic costs associated with the journey, the factors influencing the choice of pilgrimage routes based on financial capabilities, and the role of patronage, religious, and ideological foundations in shaping these pilgrimages.

Conclusion: The conclusion section encapsulates the key takeaways from the study. It summarizes the significant findings, discusses their implications, and potentially suggests avenues for further research. This part of the article serves as a culmination of the author's analysis, offering a comprehensive understanding of the complexities involved in pilgrimage travel during the specified historical period.
Problems of Maintaining Public Health, Improving Medical Culture, and Improving the Socio-Ecological Situation in Uzbekistan
Authors: Babajanova Diloram , Yermetov Avaz , Khaydarov Izzatilla , Isakov Bakhadir , Madaminova Durdona 
Published: December 2023

Objectives: The primary focus of this article is to investigate various aspects related to healthcare in Uzbek families. It aims to contribute to the improvement of medical culture and the socio-ecological situation in the region. The specific objectives include assessing and addressing problems within the healthcare system, identifying factors that influence the health and standard of living of the population, and promoting the adoption of a healthy lifestyle.

Methods: To achieve the stated objectives, the article employs a comprehensive methodology. It involves the examination of the new worldview formation, identification of social factors crucial in preventing negative situations, and an analysis of the practical activities undertaken to understand the social situation resulting from these consequences. Additionally, the research delves into proposals for changing attitudes towards the environment and fostering a healthier lifestyle.

Results: The findings of this study focus on understanding the factors contributing to environmental actions in Uzbekistan, particularly in the context of protecting the health of mothers and children. The research addresses issues related to an unhealthy environmental situation and environmental protection, aiming to reveal specific aspects that influence and shape these concerns.

Conclusion: In conclusion, this article synthesizes the research by emphasizing the critical importance of addressing environmental issues in Uzbekistan to protect the health of vulnerable populations, such as mothers and children. The findings underscore the need for concerted efforts to tackle problems associated with the socio-ecological situation. The conclusion also highlights specific aspects of the identified issues and suggests potential directions for future interventions or policies to enhance healthcare and environmental protection in Uzbek families. Overall, the article serves as a valuable contribution to the understanding of the complex interplay between healthcare, social factors, and environmental conditions in Uzbekistan.
The Role of Linguistic Anthropocentrism Theories in Uzbek National Linguistics
Authors: Khudayberganova Durdona , Mukimova Zokhida , Karimova Feruzakhon 
Published: December 2023

Objectives: The primary objective of this article is to explore the impact of the anthropocentric paradigm on Uzbek linguistics and its subsequent formation. The focus is on the shift towards an anthropocentric approach in world linguistics, especially since the late 20th century. The article aims to highlight the specific areas within Uzbek linguistics that have been influenced by this paradigm, emphasizing changes and developments in scientific views and ideas.

Methods: To achieve the stated objectives, the article employs a methodological approach that involves an examination of the anthropocentric paradigm and its integration into Uzbek linguistics. It explores how the subject of language, along with its owner, national mentality, and culture, has gained prominence in linguistic studies. The methods also include an analysis of the fields that emerged based on anthropocentric views and the notable changes witnessed in 21st-century Uzbek linguistics.

Results: The results of this study shed light on the significant impact of the anthropocentric paradigm on various aspects of Uzbek linguistics. The article analyzes the emergence of fields such as Uzbek cognitive linguistics, linguistic and cultural studies, and pragmalinguistics. It delves into the exploration of spiritual values and linguistic experiences within national-cultural communities, offering insights into the signs of interdependence between language and culture.

Conclusion: In conclusion, the article synthesizes the findings by providing general conclusions on the influence of the anthropocentric paradigm on Uzbek linguistics. It underscores the importance of studying language in conjunction with its owner and cultural context. The changes and developments observed in the 21st century within Uzbek linguistics, shaped by anthropocentric views, are highlighted. The conclusion emphasizes the continued relevance of the relationship between language and culture, as well as language and thinking, within the anthropocentric approach in world linguistics. Overall, the article contributes to the understanding of the evolving landscape of Uzbek linguistics under the influence of the anthropocentric paradigm.
PERLINDUNGAN HUKUM BAGI PEMEGANG HAK ATAS MEREK TERHADAP PENGGUNAAN MEREK TERDAFTAR OLEH PIHAK LAIN
Authors: Irwan Prasetia  , Suroto  
Published: December 2023

Suatu merek yang memiliki persamaan dengan merek yang sudah terdaftar dapat menimbulkan sengketa hak atas merek terdaftar karena dianggap merugikan pemegang merek terdftar pertama kali. Permasalahan dirumuskan sebagai berikut: 1). Apa yang melatar belakangi terjadinya sengketa hak atas merek pada Putusan Kasasi Mahkamah Agung Republik Indonesia Nomor 575 K/Pdt.Sus-HKI/2020 tanggal 20 Mei 2020? 2). Apa yang menjadi dasar pertimbangan hakim dalam memberikan perlindungan hukum bagi pemegang hak atas merek terhadap penggunaan merek terdaftar oleh pihak lain dalam Putusan Kasasi Mahkamah Agung Republik Indonesia Nomor 575 K/Pdt.Sus-HKI/2020 tanggal 20 Mei 2020? 3). Apa akibat hukum bagi para pihak atas Putusan Kasasi Mahkamah Agung Republik Indonesia Nomor 575 K/Pdt.Sus-HKI/2020 tanggal 20 Mei 2020? Penelitian ini menggunakan pendekatan yuridis normatif, spesifikasi penelitian bersifat deskriptif analitis, sumber data yaitu data sekunder, metode pengumpulan data dengan studi pustaka. Metode analisis data secara kualitatif. Hasil Penelitian menunjukkan: 1). Hal yang melatarbelakangi terjadinya sengketa hak atas merek pada Putusan Kasasi Mahkamah Agung Republik Indonesia Nomor 575 K/Pdt.Sus-HKI/2020 tanggal 20 Mei 2020, yaitu adanya gugatan pembatalan merek karena merasa sebagai pendaftar pertama (First to File). 2). Dasar pertimbangan hakim dalam memberikan perlindungan hukum bagi pemegang hak atas merek terhadap penggunaan merek terdaftar oleh pihak lain dalam Putusan Kasasi Mahkamah Agung Republik Indonesia Nomor 575 K/Pdt.Sus-HKI/2020 tanggal 20 Mei 2020, yaitu: a. Unsur Kesamaan, b. Unsur Itikad tidak baik. 3). Akibat hukum bagi para pihak atas Putusan Kasasi Mahkamah Agung Republik Indonesia Nomor 575 K/Pdt.Sus-HKI/2020 tanggal 20 Mei 2020, yaitu Ruben Samuel Onsu tidak lagi bisa menggunakan ke enam merek yang telah dibatalkan pendaftaranya oleh Pengadilan.
PENYELESAIAN SERTIFIKASI ASET PEMERINTAH DAERAH DI KABUPATEN BANYUWANGI
Authors: Siti Arini  , Widyarini Indriasti Wardani  
Published: December 2023

Sertifikasi aset Pemerintah selain sebagai bentuk tertib administrasi juga menjadi atensi dari KPK, karena sertifikasi aset merupakan upaya pencegahan kehilangan aset negara. Pemerintah Daerah Kabupaten Banyuwangi bersama Kantor Pertanahan Kabupaten Banyuwangi tengah mendaftarkan seluruh bidang tanah asetnya namun belum semua aset tersebut dapat disertifikasi/disertifikatkan. Oleh karena itu, penting untuk mengetahui dan menganalisis bagaimana penyelesaian pendaftaran tanah aset Pemerintah Banyuwangi; jenis Hak Atas Tanah yang diberikan; dan hambatan apa yang terjadi serta upaya yang dapat diambil untuk mengatasinya. Hasil penelitian ini antara lain Penyelesaian sertifikasi aset Pemerintah Daerah Kabupaten Banyuwangi dilaksanakan sesuai dengan perundang-undangan yang mengatur pendaftaran tanah. Kantor Pertanahan memberikan fasilitas loket prioritas serta tim khusus agar sertifikasi aset Pemerintah dapat segera diselesaikan. Hak atas tanah yang diberikan kepada Pemerintah Daerah adalah Hak Pakai Selama Dipergunakan. Jenis hak ini diberikan karena penggunaan bidang tanah aset yang didaftarkan untuk kepentingan umum/masyarakat banyak. Beberapa kendala yang dihadapi dalam pendaftaran aset antara lain, terjadinya pencatatan ganda antar instansi, masuknya aset pada kawasan kehutanan, ketidaklengkapan bukti alas hak, ketidaksingkronan satuan data, Sumber Daya Manusia, serta kendala penganggaran. Kendala tersebut dapat diatasi dengan mengadakan rapat koordinasi lintas instansi dengan supervisi dari KPK agar masing-masing instansi dapat saling melakukan crosscheck asetnya, Koordinasi dengan Kementerian Kehutanan, pembuatan Surat Pertanggungjawaban Mutlak dari Kuasa Pengguna Barang sebagai penguat alas hak, persiapan sertifikasi aset serta penganggaran dilakukan satu tahun sebelum dilaksanakan, bekerja sama dengan kantor pertanahan mengadakan pelatihan pendaftaran tanah untuk pegawai.