bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained response off‐treatment in eltrombopag‐treated adult patients with ITP who are refractory or relapsed after first‐line steroids: Primary, final, and ad‐hoc analyses of the Phase II TAPER trial
Authors: Cooper Nichola , Ghanima Waleed , Vianelli Nicola , Valcárcel David , Yavaşoğlu İrfan , Melikyan Anait , Ruiz Eduardo Yañez , Haenig Jens , Somenzi Olivier , Lee James , Clark Joan , Zhang Yifan , Zaja Francesco 
Published: November 2023

AbstractImmune thrombocytopenia (ITP) is characterized by reduced platelet count due to increased destruction and is categorized according to the time following diagnosis (newly diagnosed, persistent, chronic). First‐line corticosteroid therapy is associated with transient response, high relapse rates, and considerable toxicity. TAPER (NCT03524612) is a Phase II, prospective, single‐arm trial investigating whether eltrombopag can induce a sustained response off‐treatment (SRoT) in adult patients with ITP after first‐line corticosteroid failure. This study defines SRoT as an off‐treatment period wherein platelet count remains above 30 × 109/L in the absence of bleeding or rescue therapy. The primary endpoint was the proportion of patients who achieved SRoT until Month 12, which was 30.5% (n = 32/105; p < .0001 testing hypothesis H1: proportion >15%) following eltrombopag tapering and discontinuation, and median SRoT duration was ~8 months until Month 12. Median platelet count increased within 1 month of treatment and remained elevated until Month 12. Quality of life improved within 3 months and was maintained. Headache (21%) was the most common adverse event. None of the 4 deaths reported were considered treatment‐related. In summary, ~one‐third of patients achieved SRoT until Month 12 following eltrombopag tapering and discontinuation. An ad‐hoc early‐use analysis, stratified by ITP duration at baseline, assessed initial hematologic responses and safety. Results suggest that eltrombopag has similar efficacy in newly diagnosed and later stages of ITP. In follow‐up until Month 24, a median SRoT duration of ~22 months was observed (n = 20). The safety profile was comparable across analyses and ITP duration groups and aligned with its well‐established safety profile.
Emergency department activities at the Athletes' Village during the Tokyo 2020 Olympic and Paralympic Games
Authors: Kuroki Norihiro , Yagishita Kazuyoshi , Shimizu Keiki , Okuaki Sachiko , Doi Yuuri , Arakawa Yuki , Nakano Tomotsugu , Akama Takao 
Published: November 2023

AbstractAimMore than 15,000 elite athletes participated in the Tokyo 2020 Olympic and Paralympic Games. Providing adequate medical services to these elite athletes was a priority. Hence, a polyclinic was established in the Athletes' Village. Visitors were triaged at the emergency department of the polyclinic to enable early treatment of critical illnesses or injuries in the emergency room (ER) and to identify patients suspected of having coronavirus disease as early as possible. No reports of emergency department activities at large sporting events in the pandemic era are available. Here, we aim to summarize the activities at the emergency department of the polyclinic.MethodsData were collected using an electronic medical record system, nursing records, and questionnaires administered during triage from July 13 to September 8, 2021. Polyclinic data involving accredited athletes and team members were summarized.ResultsDuring the Olympic Games, 12,318 triage cases were reported, of which 75 were treated in the ER. During the Paralympic Games, 8398 triage cases were reported, of which 94 were treated in the ER. During the Olympic Games, musculoskeletal issues (26 patients) were the most common. During the Paralympic Games, ear, nose, and throat issues were the most common (21 patients). Two patients experienced cardiopulmonary arrest in the Athletes' Village and were transported to the hospital postresuscitation.ConclusionDuring the study period, many critically ill patients were triaged and treated at the emergency department. Our data can be used to improve medical care and infection prevention at future international sporting events.
Finite‐Frequency Noise and Dynamical Charge Susceptibility in Single and Double Quantum Dot Systems
Authors: Richard Samuel , Lavagna Mireille , Crépieux Adeline 
Published: November 2023

AbstractThis study reports on finite‐frequency noise and dynamical charge susceptibility in out‐of‐equilibrium quantum dot systems. Both single and double quantum dots connected to one or two reservoirs of electrons are considered, and these quantities are calculated by using the non‐equilibrium Green function technique. The results are discussed in the light of experimental results, particularly in the low‐frequency limit for which an interpretation in terms of an equivalent RC‐circuit is made. Anti‐symmetrized noise is also studied, defined as the difference between absorption and emission noises, and its relationship with the dynamical charge susceptibility in single quantum dots is established. In double quantum dots, the similarities between the dynamical charge susceptibility, the absorption noise, and the dot occupancy, are highlighted by comparing their respective variations with the bias voltage applied between the two reservoirs, and the detuning energy defined as the difference between the lowest level energies in the two dots.
Photonic Spin Hall Effect as a Highly Sensitive Refractive Index Sensing Platform for Glucose
Authors: Dong Peng , Xiang Yinjie , Cheng Jie 
Published: November 2023

AbstractThis study presents an innovative refractive index (RI) sensor that measures glucose concentration by utilizing the photonic spin Hall effect (SHE) in a resonant optical tunneling effect (ROTE) structure. The ROTE structure consists of three InP layers with the high RI and two analyte layers (with a high‐low‐high‐low‐high RI distribution), in which glucose solution samples with the low RI are injected. By subjecting the InP layers to external bias‐assisted light, the photonic SHE can be flexibly manipulated, enabling the modulation of the sensing performance accordingly. It is found that the transverse shift of photonic SHE presents a large variation in response to the tiny change in glucose concentrations. By optimizing the parameters (i.e., intensity or wavelength) of bias light, the sensitivity of this sensor can reach as high as 735.7 µm RIU−1. Compared to traditional glucose sensors, this original work implements the novel photonic SHE with the superior sensing performance. Therefore, the proposed design shows promising potential for biomedical applications, such as medical diagnoses and drug discovery.
Effect of infrared roasting of perilla seeds on the content of bioactive components and antioxidant capacity in oil
Authors: Huang Jianhua , Xu Yu , Chen Chuying , Song Zhihua , Chang Ming , Wang Xingguo , Wang Xiaosan 
Published: November 2023

AbstractThe effects of different infrared roasting temperatures (120, 140, and 160°C) and time (0, 10, 15, and 20 min) on the oxidative stability and content of active components in perilla oil were investigated. Fatty acid is one of the active components in perilla oil. The findings demonstrated that infrared baking had little impact on the fatty acids in perilla seed oil. The oxidative stability of perilla oil increased with the rising temperature of the infrared heating process. Phenolic substances were used as main antioxidants of polar extracts from perilla seed oil. Oxidative stability of perilla seed oil was highest after 20 min of exposure to 140°C. Furthermore, the amount of phenolic compounds and the DPPH radical scavenging activity of perilla seed oil treated at 140°C for 20 min were significantly higher compared to other infrared treatments, while the amount of total tocopherol was significantly lower. These results indicated that the quality and characteristics of perilla seed oil could be effectively improved by pressing perilla seed after infrared pretreatment.
Housing demolition and labour force participation: A gender difference perspective
Authors: Hu Mingzhi , Zhang Yating 
Published: November 2023

AbstractExisting research suggests that housing demolition negatively affects labour supply through the wealth effect of the demolition compensation. However, there is limited research on the gender differences in the impact of housing demolition on labour force participation. This study investigates the effects of housing demolition on labour force participation, with a specific focus on the gender difference. Using data from the Chinese Family Panel Studies, this study reveals a significant decline in labour force participation resulting from housing demolition, primarily driven by females. Moreover, housing demolition exerts a stronger effect on the labour force participation of married women, who tend to take on more responsibilities for household chores, while its impact on married men is less evident. These findings offer valuable insights into the issue of labour shortage and underscore the importance of reducing the traditional gender‐based division of household labour.
Topohistology of the cranial nerves IX–XII at the cranial base and upper parapharyngeal space: A histological study using human fetuses
Authors: Cho Kwang Ho , Honkura Yohei , Kim Ji Hyun , Hayashi Shogo , Kitamura Kei , Murakami Gen , Rodríguez‐Vázquez Jose Francisco 
Published: November 2023

AbstractThe topographical relationships among the lower cranial nerves, internal carotid artery (ICA), and internal jugular vein (IJV) in the upper parapharyngeal neurovascular bundle remain obscure. Thus, details of the anatomy were examined in human fetus histology. We observed the horizontal histological sections from 20 midterm (9–18 weeks) and 12 near‐term (28–40 weeks) fetuses. At the external skull base, the glossopharyngeal nerve crosses the anterior aspect of the IJV to reach the medially located Hyrtl's fissure in the petrous temporal bone. The nerve crossed the anterior aspect of the ICA medially near or below the first cervical nerve root. Below the hypoglossal nerve canal, the accessory nerve crosses the anterior or posterior aspects of the IJV and moves laterally. During the half‐spiral course, the hypoglossal nerve was tightly attached to the posterolateral–anterior aspects of the vagus nerve and surrounded by a common nerve sheath. The glossopharyngeal ganglia sometimes extended inferiorly to the level of the hypoglossal nerve canal but were absent along the inferior course. The inferior vagal ganglion rarely extends above the occipital condyle. The superior cervical sympathetic ganglion occasionally extends above the first cervical nerve root. The IJV (or ICA) descends to the lateral (or medial) margins of the parapharyngeal neurovascular bundle. The glossopharyngeal (or accessory) nerve crosses the ICA (or IJV) to exit the bundle at the base of the skull (or below the hypoglossal nerve canal). The glossopharyngeal and vagus inferior ganglia differ at each site.
The Reduction of Metallabenzenes: Different Scenarios Highly Dependent on the Central Group 14 Elements, Si vs. Ge
Authors: Tsuji Shingo , Tokitoh Norihiro , Yamada Hiroko , Mizuhata Yoshiyuki 
Published: November 2023

AbstractIn order to synthesize a silabenzenyl anion, in which the anionic carbon atom of a phenyl anion was replaced with a silicon atom, the reductive dearylation reaction of 1‐Tbt‐2‐tert‐butyl‐silabenzene (Tbt=2,4,6‐tris[bis(trimethylsilyl)methyl]phenyl) with KC8 was attempted. Unexpectedly, this reaction resulted in the formation of a dianion species without the elimination of the Tbt group. This is totally different from the reactions of Tbt‐substituted germa‐ or stannabenzene with KC8, which resulted in the formation of the corresponding heavy analogues of phenyl anion, together with the elimination of Tbt group. Experimental and theoretical investigation revealed that one of the protons of the o‐benzyl positions of the Tbt group was abstracted by the negatively charged silicon atom of an in‐situ generated intermediate. Compared with the previously reported germanium system, the contrasting results indicate that the central heavy group 14 element has a great influence on the elimination step of the Tbt group.
Face‐to‐face live eye‐tracking in toddlers with autism: Feasibility and impact of familiarity and face covering
Authors: Vernetti Angelina , Butler Maureen , Banarjee Chitra , Boxberger Alexandra , All Katherine , Macari Suzanne , Chawarska Katarzyna 
Published: November 2023

AbstractStudies utilizing eye‐tracking methods have potential to promptly capture real‐world dynamics of one of the core areas of vulnerability in autism spectrum disorders (ASD), selective social attention. So far, no studies have successfully reported utilizing the method to examine social attention in toddlers with neurodevelopmental vulnerabilities in real world and challenging settings such as an interactive face‐to‐face. This study examined the feasibility and validity of live eye‐tracking method in response to live interaction occurring in several contexts in toddlers with and without ASD. Forty‐seven toddlers with ASD, with atypical development (ATYP), or typically developing (TD), underwent a 30‐s live eye‐tracking procedure during a face‐to‐face interaction with a masked stranger using child‐directed‐speech (16 ASD, 14 ATYP, 17 TD; Mage = 23.44 months, SD = 6.02). Out of this group of toddlers, 29 (10 ASD, 8 ATYP, 11 TD, Mage = 21.97 months, SD = 5.76) underwent the same procedure with one of their maskless parent. Task completion rate, calibration accuracy, and affective response (feasibility measures) as well as attention to the task and the social partner (validity measures) were examined. Task completion rate and calibration accuracy were excellent. Despite the challenging context of face‐to‐face interaction, the toddlers exhibited a neutral affect, and high attention to the task and the speaker. As anticipated, toddlers with ASD looked less at the social partner compared with control groups. However, attention was comparable between the Stranger and Parent conditions, indicating that the effect was consistent regardless of presence of face covering or the familiarity of the interactive partner. The study demonstrates the high feasibility and validity of a live eye‐tracking task involving face‐to‐face interaction in neurodiverse toddlers with social vulnerabilities. The effect of diminished attention to social partners in toddlers with autism is robust and present when interacting with an unfamiliar person and parent. The results suggest that a brief live eye‐tracking method constitutes a promising ecologically valid candidate biomarker and potential intervention outcome in autism.
Research progress in the application of proteomics technology in brain injury
Authors: Liu Wenhu , Wen Zhaomeng , Shi Yuwei , Bao Juan , Ma Shaobo , Liang Jin 
Published: November 2023

AbstractThe aim of this article is to review the application progress of proteomics technology in brain injury research in recent years, point out the current problems that need to be overcome, and explore the application prospects of proteomics analysis in brain injury. This study also aims to retrieve all literature on brain injury and proteomics and summarize it. Through searching and screening, the widespread application of proteomics technology in the treatment of traumatic brain injury (TBI) and the use of a large number of TBI biomarkers were discovered. The pathways mediated by some biomarkers and the physiological and pathological mechanisms of occurrence were elucidated. The current classification of brain injury is mainly based on subjective evaluation of clinical symptoms, combined with objective imaging. However, its practical value is often limited when applied to prognosis evaluation in brain injury. Proteomics technology can make up for this deficiency and provide a reference for the prevention and treatment of brain injury.
‘Attachment is such a core issue’: Therapist perspectives on attachment injuries in marriages in India
Authors: Oberoi Nikita , Desai Geetha , Satyanarayana Veena A. 
Published: November 2023

AbstractBackgroundMarital distress is a risk factor for a panoply of mental and physical health disorders. One of the causes of marital distress that is increasingly gaining relevance is attachment injuries in the marital relationship. Emerging from the confluence of adult attachment theory and emotionally focussed couples therapy, attachment injuries refer to tears in the relationship bond caused by abandonment or betrayal in the marriage, especially at times of critical need when attachment needs are salient.ObjectiveThe objective of this study was to investigate how therapists in India conceptualise and assess attachment injuries in marital relationships.MethodA qualitative design was used, whereby in‐depth interviews were conducted with 13 therapists and the transcripts were analysed using thematic analysis.ResultsThe analysis resulted in two overarching themes. The first was ‘Attachment Injuries are a Common Phenomenon in Couples undergoing Marital Distress’, which included themes related to markers of attachment injuries, injurious events, the gendered nature of attachment injury experiences and the impact of attachment injuries. The second overarching theme was ‘Therapists Utilize Diverse Methods for the Crucial Process of Identification of Attachment Injuries’, which included themes related to the methods used for assessment, the significance of attachment lens, the role of early experiences and the utility of identifying attachment injuries.ConclusionThe results highlighted how attachment injuries, originating from various injurious events, are often a component of marital distress in couples accessing therapy. The findings also pointed towards the need for therapists to develop competency in assessing and addressing attachment injuries, irrespective of their primary therapy orientation.
Picroside III Ameliorates Colitis in Mice: A Study Based on Colon Transcriptome and Fecal 16S Amplicon Profiling
Authors: Sun Yating , Zhang Yingdi , Wang Tao , Wen Liping , Xing Tianhang , Peng Jiao , Liang Yue 
Published: November 2023

AbstractPicroside III (Pic), an iridoid glycoside derived from Picrorhiza scrophulariiflora, exhibits therapeutic potential in mending damage to the intestinal mucosa. This study aimed to explore Pic′s regulatory impact on intestinal inflammation and the gut microbiota in mice with dextran sulfate sodium (DSS)‐induced colitis. The findings revealed that pretreatment with Pic mitigated the DSS‐induced escalation of the disease activity index (DAI), alleviated intestinal damage, and attenuated intestinal inflammation in mice. RNA‐seq analysis, complemented by experimental validation, elucidated that Pic significantly hindered Akt phosphorylation in the colon tissues of colitis‐afflicted mice. Furthermore, 16S rRNA sequencing demonstrated that Pic pretreatment effectively rectified microbial dysbiosis in colitis mice by elevating the abundance of Lactobacillus murinus and Lactobacillus gasseri. These observations suggest that Pic′s efficacy in colitis treatment stems from its inhibition of intestinal inflammation via the suppression of the PI3K‐Akt pathway and modulation of gut microbiota. This study contributes novel scientific insights into the potential application of Pic in the management of inflammatory bowel disease (IBD).
Real‐world experience of rIX‐FP prophylaxis at dosing intervals of up to 14 days in a pediatric patient with hemophilia B during the COVID‐19 pandemic
Authors: Díaz‐Jordán Bolívar Luis , Cebanu Tamara , García Barcenilla Sara , Álvarez‐Román Maria Teresa 
Published: November 2023

Key Clinical MessageSwitching to rIX‐FP prophylaxis at dosing intervals of up to 14 days in a hemophilia B pediatric patient decreased treatment burden by reducing the number of administrations and hospital visits, without affecting efficacy or treatment adherence. This is particularly important in contexts of limited mobility and overloaded healthcare services.
Lipid‐poor vertebral hemangioma mimicking a vertebral metastasis of cervical carcinoma
Authors: Traore Wend‐Yam Mohamed , Ait Belhaj El Mahdi , Compaore Bertrand Ghislain , Touarsa Firdous , Lahfidi Amal , Jiddane Mohamed 
Published: November 2023

Key Clinical MessageVertebral hemangiomas are classified into typical and atypical forms. On imaging, atypical forms may look like malignant lesions. The confrontation of data from different imaging modalities (MRI; CT; scintigraphy) facilitates the diagnosis.
Lemierre syndrome causing empyema and pulmonary embolism: A reemerging disease from a bygone era?
Authors: Jassal Shalvin Singh , Steen Christopher , Wong Enoch 
Published: November 2023

Key Clinical MessageLong considered a “forgotten disease” of a bygone era, the apparent reemergence of Lemierre syndrome highlights the need for awareness of this rare condition to ensure timely diagnosis and treatment. Lemierre syndrome should be suspected in young adults presenting with a chest or neck infection and requires prolonged antibiotic therapy, surgical drainage of collections, and often anticoagulation.
Unraveling a rare presentation of bivalvular infective endocarditis using POCUS
Authors: Dvalishvili Mariam , Ahmad Soban , Qavi Ahmed Hassaan , Ardhanari Sivakumar 
Published: November 2023

Key Clinical MessageInfective endocarditis (IE) is rare, and involvement of two valves is rarer yet. We present a case of a 22‐year‐old male with liver failure who was found to have bivalvular IE. This case sheds light on the association between bivalvular IE and seemingly unrelated symptoms, emphasizing the need for early recognition.
Surviving the perilous: A case report on an urgent approach to necrotizing fasciitis
Authors: Kunwor Bishal , Chhetri Suchit Thapa , Thapa Niranjan , Regmi Shiva , Basukala Sunil 
Published: November 2023

Key Clinical MessageNecrotizing fasciitis is a rare, fatal, and rapidly progressing bacterial infection of fascia and subcutaneous tissues. Skin necrosis, pain, bullae, and erythema are the common manifestations. Early diagnosis and prompt treatment can improve outcome.
Transesophageal echocardiography combined with ProAQT/PulsioFlex hemodynamic monitoring in anesthetic management of a patient with septic shock associated with septic cardiomyopathy: A case report
Authors: Gu Hui , Yang Lei 
Published: November 2023

Key Clinical MessagePatients with septic shock complicated by septic cardiomyopathy (SCM) can be extremely ill and at high risk for mortality. If early assessment of cardiac function is neglected during treatment, sepsis may be further exacerbated. We report a 77‐year‐old male patient with severe septic shock who underwent intraoperative transesophageal echocardiography (TEE) because of progressive circulatory instability, SCM was diagnosed. Further perioperative treatment to support the circulation was successfully adjusted based on TEE and pulse index continuous cardiac output (CO) by ProAQT/PulsioFlex hemodynamic monitoring. We should consider a diagnosis of SCM in the perioperative period and perform ultrasonography routinely. The use of TEE with ProAQT/PulsioFlex offers a new option for anesthetic management.