bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learnings in Digital Health Design: Insights From a Pilot Web App for Structured Note-Taking for Patients With Rheumatoid Arthritis
Authors: Srivastava Ujwal , Dasari Shobha , Shah Neha 
Published: October 2023

Background
Patients fail to accurately remember 40% to 80% of medical information relayed during doctor appointments, and most standard after-visit summaries fail to effectively help patients comply with behaviors to manage their health conditions. The value of technology to empower and engage patients in their health management has been shown, and here we apply technology to help patients remember and act upon information communicated during their medical appointments.

Objective
We describe the development of WellNote, a digital notebook designed for patients to create a customized plan to manage their condition, plan for their appointments, track important actions (eg, medications and labs), and receive reminders for appointments and labs.

Methods
For this pilot, we chose to focus on rheumatoid arthritis, a chronic condition that relies on many of these features. The development of WellNote followed a structured method based on design thinking and co-design principles, with the app built in close collaboration with patients and a physician partner to ensure clinical relevance. Our design process consisted of 3 rounds: patient and physician interviews, visual prototypes, and a functional pilot app.

Results
Over the course of the design process, WellNote’s features were refined, with the final version being a digital notebook designed for patients with rheumatoid arthritis to manage their health by helping them track medications and labs and plan for appointments. It features several pages, like a dashboard, patient profile, appointment notes, preplanning, medication management, lab tracking, appointment archives, reminders, and a pillbox for medication visualization.

Conclusions
WellNote’s active and structured note-taking features allow patients to clearly document the information from their physician without detracting from the conversation, helping the patient to become more empowered and engaged in their health management. The co-design process empowered these stakeholders to share their needs and participate in the development of a solution that truly solves pain points for these groups. This viewpoint highlights the role of digital health tools and the co-design of new health care innovations to empower patients and support clinicians.
Diabetes mellitus and COVID-19: living with double risk
Authors: Muravlova O.V. , Shaienko Z.O. , Dvornyk I.L. , Sizova L.M. , Ilchenko V.I. , Purdenko T.I. , Shpetnyi O.A. 
Published: October 2023

Background. The purpose is to analyze and summarize the studies conducted to determine the impact of COVID-19 on the course of diabetes mellitus and the manifestations of chronic complications of this disease. Materials and methods. We did the search in PubMed and ScienceDirect databases using the following line: “SARS-CoV-2 or COVID-19 and diabetes or hyperglycemia”. Results. It was found that in patients with diabetes, the severity of COVID-19 is increased. In particular, the number of those who needed intensive care or artificial ventilation has elevated. The same negative trend is noted for the overall mortality rate in patients with diabetes. It has been found that COVID-19 contributes to an increase in the development of diabetes, including diabetic ketoacidosis, hyperosmolar syndrome, brain stroke and mental health disorders, which can potentiate the effect of COVID-19 in enhancing the manifestations of diabetes and double risk for these patients. Along with this, the common pathways of the pathogenesis of diabetes and COVID-19 determine the bidirectionality of the interaction in their comorbidity. Conclusions. We have demonstrated numerous links between COVID-19 pathogenetic mechanisms and diabetes. Despite this, current research shows only modest evidence of an increased risk of metabolic, neurological, and psychiatric complications in patients with diabetes who had COVID-19. However, along with the direct impact of patients’ infection, the conditions of pandemic are also affected, which complicate access to the necessary care and should be taken into account when studying the clinical consequences of COVID-19 in patients with diabetes.
Mitigation of 3-MCPDE and GE in palm oil in Indonesia
Authors: Elisabeth Jenny 
Published: October 2023

Among consumed-vegetable oils, RBDPO (refined, bleached and deodorized palm oil) is indicated containing higher level of 3-MCPDE and GE, which have been classified as potentially carcinogenic and/or genotoxic to human. Those contaminants in RBDPO are formed during deodorization process with high temperature and also correlate with chloride content and quality of CPO as raw material. The maximum limit for 3-MCPDE and GE content in vegetable oil has been set at 2500 and 1000 µg kg-1, and as low as 750 and 500 µg kg-1 when used for production of baby food and cereal-based foods for infants and young children. The mitigation of 3-MCPDE and GE in RBDPO is quite challenging for palm oil refineries in producing a good quality of palm oil in term of sensory, stability, safety, and nutritional value, especially in Indonesia. It has been proven that modification of conventional refining process can reduce the 3-MCPDE and GE content. They are including pre-treatment of CPO by water washing to reduce the chloride content, alkali neutralization to remove any acids present in the oil prior to deodorization, using neutral bleaching earth, adding antioxidants after bleaching to reduce free radical-mediated formation of 3-MCPDE and GE, lowering the deodorization temperature with a longer time, and even double bleaching and/or double deodorization of the palm oil. Post-refining treatment using specific adsorbents is also applied to remove the 3-MCPDE and GE. However, palm oil refineries have to apply combination of several mitigation strategies to adequately reduce the levels of 3-MCPDE and GE, including using good quality of CPO with low FFA, chloride, and oxidized components content.
ANALISIS KANDUNGAN METABOLIK SEKUNDER PADA DAUN KENIKIR (Cosmos Caudatus Kunth.) DENGAN PELARUT METANOL, ETANOL, DAN ETIL ASETAT
Authors: Masitah Masitah , Pribadi Teguh , Pratama Mohammad Indra , Harrist Reynaldi Ferdhani , Sari Prita Asminitya , Dianita Feby , Setiawan Volta Kellik 
Published: October 2023

Cosmos Caudatus Kunth. is one of the most commonly found medicinal plants. Cosmos leaves contain phytochemical compounds such as terpenoids, fatty acids, flavonoids, alkaloids, tannins, and saponins. This study aims to determine the effect of differences in methanol, ethanol, and ethyl acetate solvents on the phytochemical tests of Cosmos leaf samples. The study was conducted in the Biology Education Laboratory, Faculty of Teacher Training and Education, Mulawarman University, as well as the Organic Chemistry Laboratory, Faculty of Mathematics and Natural Sciences, Mulawarman University. Qualitative phytochemical screening is conducted by assessing the solubility qualities of the substances. The findings from the examination of secondary metabolic chemicals indicate that the methanol extract derived from Cosmos leaves comprises alkaloids, triterpenoids, flavonoids, phenolics, and quinones. While the ethanol extract of Cosmos leaves contains alkaloids, flavonoids, saponins, phenolics, and quinones. There is an ethyl acetate extract of Cosmos leaves, alkaloids, steroids, flavonoids, phenolics, and quinones.
Modern Javanese Canned Gudeg Viewed from Cultural, Food Safety, and Visual Design Perspectives
Authors: Utami Maya Putri , Maulana Anand Reyna , Dukut Ekawati Marhaenny , Wulandari Dyah 
Published: October 2023

Gudeg, a traditional culinary dish from Yogyakarta, Indonesia, is prepared by cooking young jackfruit with coconut milk and spices. It is commonly served with rice, eggs, chicken, and sambal goreng krecek, which is a spicy blended chili cooked with savory edible soft cowhide. Gudeg is interesting to discuss as it holds a rich history and is a cultural legacy that has been passed down through generations in Indonesia. Over time, gudeg producers have introduced an innovation of providing a visually attractive label on canned packages. This gives reason for research on gudeg using a cultural, food safety, and visual design perspective. The research found that culturally gudeg was the staple for the Mataram Kingdom army to survive the battle against enemies who wanted to colonialize the area. Next, the food safety test revealed that canned Gudeg Bagong had a microbial count of 1.3 x 10-1 CFU/ml, while canned Gudeg Andrawina Loka had a count of 2.4 x 10-2 CFU/ml. The findings demonstrated that the microbiological analysis met the standards set by Ministry of Health Regulation No. 416/MENKES/PER/IX/1990 and Indonesian Food and Drug Authority Regulation No. HK.00.06.1.S2.4011. Lastly, through visual design research, it was found among others that local and foreign tourists prefer to see the actual photo display of gudeg set with its jackfruit, egg, chicken, and sambal goreng krecek contents.
A COMPARATIVE ANALYSIS BETWEEN TRADITIONAL AND ALTERNATIVE EARLY CHILDHOOD EDUCATION, SUCH AS THE MARIA MONTESSORI METHOD, REGGIO EMILIA PEDAGOGICAL APPROACH
Authors: Avetisyan Mariana , Konjoyan Hasmik 
Published: October 2023

This article aims to conduct a comparative analysis between early childhood traditional education and alternatives in primary education, such as the Maria Montessori method and Reggio Emilia approach. This article will be relevant and advisable for educators and parents to understand the key differences between each approach. There is no doubt that early childhood education plays an essential role in educating young minds. The question is how to find the best way to educate young children, what to choose: teacher-centered or child-centered models of teaching? Furthermore, from a parental view, the question is not only which method works the best, but also which one is more beneficial for “My Child”. Parents have difficulty choosing the right teaching option specifically for their children, which would help them become successful members of modern society in the future.
Taking into consideration our teaching experience of more than twenty-five years, along with researching many pedagogical and educational books and articles, we came to an interesting conclusion about both – traditional and alternatives in teaching young minds. Alongside, we discovered that no matter how beneficial is the true idea of any teaching method, unfortunately, not every school is a true barrier to the philosophy, theory, and teaching approach behind the school’s name brand.
Receptor-based approaches and therapeutic targets in Alzheimer’s disease along with role of AI in drug designing: Unraveling pathologies and advancing treatment strategies
Authors: Patwekar Mohsina , Patwekar Faheem , Shaikh Daniyal , Fatema Shaikh Rohin , Aher Sunil J. , Sharma Rohit 
Published: October 2023

Alzheimer’s disease (AD) is a prevalent cause of dementia in the elderly, characterized by progressive cognitive decline and neurodegeneration. This review focuses on the etiology of AD, the role of various receptors [TNF (Tumor necrosis factor) receptor, nAChR (Neuronal nicotinic acetylcholine receptors), NMDARs (N-Methyl-D-aspartate receptors), APOE (Apolipoprotein E) receptor, and amyloid-beta receptor], and risk factors contributing to its development. AD progresses through mild, moderate, and severe stages, each exhibiting distinct symptoms. The hallmark pathologies are neurofibrillary tangles and amyloid plaques, comprised of hyperphosphorylated tau protein and amyloid-beta peptides, respectively. Current pharmacotherapeutic options alleviate symptoms but lack a complete cure. To address the challenges in developing effective AD treatments, researchers have turned to artificial intelligence (AI) and computational approaches in drug design. AI techniques, including machine learning and molecular docking, enable the analysis of large datasets and prediction of molecular interactions between potential drug candidates and target receptors. Virtual screening and molecular modeling aid in identifying novel therapeutic compounds. Predictive modeling and optimization algorithms optimize drug properties and predict efficacy. AI also facilitates the repurposing of existing drugs by analyzing their interactions with AD-related receptors and pathways. Clinical trial optimization using AI algorithms enhances patient selection, treatment monitoring, and outcome prediction. Integrating AI into AD drug design holds tremendous promise for accelerating the discovery of effective interventions. By leveraging AI’s capabilities, researchers can efficiently analyze extensive data, predict drug-target interactions, and optimize drug properties, leading to the identification of novel AD treatments. However, further research and validation are needed to translate AI-driven drug design approaches into clinically viable solutions for AD patients. Through continued advancements in AI and collaborative efforts, the development of targeted and advanced therapies for AD is within reach.
Adrenomedullin induces cisplatin chemoresistance in ovarian cancer through reprogramming of glucose metabolism
Authors: Dou Lei , Lu Enting , Tian Dongli , Li Fangmei , Deng Lei , Zhang Yi 
Published: October 2023

Abstract

Background and Objectives
The metabolic network of cancer cells has been reprogrammed – relying more on aerobic glycolysis to gain energy, which is an important reason for drug resistance. Expression of adrenomedullin (ADM) in ovarian cancer tissues is related to resistance to platinum-based drugs. In view of this, we intended to investigate the correlation between ADM and glucose metabolism reprogramming of tumor cells to clarify the possible mechanism of ADM-induced ovarian cancer cisplatin resistance through glucose metabolism reprogramming.

Methods
Epithelial ovarian cancer (EOC) cell viability and apoptosis were determined. Different gene expression and protein levels were detected by real-time revere transcription polymerase chain reaction and western blotting. Oxygen consumption rate (OCR) and extracellular acidification rates (ECARs) were measured.

Results

ADM expression was upregulated in cisplatin-resistant EOC cells. ADM attenuated cisplatin-inhibited cell survival and cisplatin-induced apoptosis in sensitive EOC cells; knockdown of ADM enhanced cisplatin chemosensitivity of cisplatin-resistant EOC cells. ADM enhanced glycolysis in cisplatin-sensitive EOC cells; knockdown of ADM significantly inhibited glycolysis in cisplatin-resistant EOC cells. ADM significantly upregulated pyruvate kinase isozyme type M2 (PKM2) protein level, the key enzyme during glycolysis; PKM2 inhibitor significantly abolished the ADM-improved cell survival and ADM-inhibited apoptosis.

Conclusion
ADM promoted proliferation and inhibited apoptosis of ovarian cancer cells through reprogramming of glucose metabolism, so as to promote cisplatin resistance. The study is expected to identify multidrug resistance markers of ovarian cancer and provide a target for the prevention and treatment of ovarian cancer, which is important for clinical translational research.
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke
Authors: Luan Yingyi , Huang Enping , Huang Jiajia , Yang Zhenjia , Zhou Zhipeng , Liu Yan , Wang Conglin , Wu Ming 
Published: October 2023

Abstract

Background and Objectives
Myoglobin released by rhabdomyolysis (RM) is considered to be involved in pathogenesis of kidney disease caused by crush injury, but whether high level of serum myoglobin predisposes patients to acute kidney injury (AKI) and its molecular mechanisms are still unclear in exertional heatstroke (EHS). We aimed to determine the association and potential mechanism of myoglobin and AKI, and further investigate the targeted therapeutic agents for myoglobinemia.

Methods
Serum myoglobin concentrations in patients with EHS were measured at admission, 24 h and 48 h after admission and discharge. The risk of AKI at 48 h was the primary outcome; the secondary outcome was composite outcome events with myoglobin levels and AKI at discharge and death at 90 days. In experimental studies, we further investigated the mechanisms of human kidney proximal tubular (HK-2) cells that were exposed to human myoglobin under heat stress conditions and the effect of baicalein.

Results
Our measurements showed that the highest myoglobin quartile (vs. the lowest) had an adjusted odds ratio (OR) of 18.95 (95% confidence interval [CI], 6.00–59.83) for AKI and that the OR (vs. quartile 2) was 7.92 (95% CI, 1.62-38.89) for the secondary outcome. The survival rate of HK-2 cells treated with myoglobin under heat stress was significantly decreased, and the production of Fe2+ and reactive oxygen species (ROS) was markedly increased, accompanied by changes in ferroptosis proteins, including increased p53, decreased SLC7A11 and GPX4, and alterations in endoplasmic reticulum stress (ERS) marker proteins. Treatment with baicalein attenuated HK-2 cell ferroptosis induced by myoglobin under heat stress through inhibition of ERS.

Conclusions
High myoglobin was associated with AKI in the EHS, and its mechanisms involved ERS-associated ferroptosis. Baicalein may be a potential therapeutic drug for the treatment of AKI in patients with high myoglobin induced by rhabdomyolysis following EHS.
The crucial role of gadolinium-enhanced MRI in a case of amaurosis fugax – a case report and literature review
Authors: Manea Maria Mirabela , Dragoş Dorin , Dobri Ana-Maria , Ghenu Maria Iuliana , Stoican Iulia-Cosmina , Enache Iulia-Ioana , Tuta Sorin 
Published: October 2023

Abstract
Optic perineuritis is the inflammation of the optic nerve sheath. This affliction can lead to visual field impairment and other signs and symptoms related to the orbital space, such as pain, disc edema, ophthalmoplegia, proptosis. However, not all patients present with such suggestive symptoms, requiring a thorough assessment. We report the case of a young male admitted to our hospital for recurrent episodes of monocular blindness. Amaurosis fugax is a well-known presentation of transient ischemic attacks (TIA) and it was ruled out. Gadolinium-enhanced MRI revealed a typical aspect of optic perineuritis. It was mandatory to consider all possible causes of secondary optic perineuritis as they all represent serious clinical conditions, even if the idiopathic form is more frequent. The clinical and paraclinical evaluation of the patient excluded an underlying disease and primary optic perineuritis was diagnosed. Corticosteroid therapy is usually curative and a course of methylprednisolone was initiated for our patient with good outcome. However, response to treatment is not diagnostic as both primary and secondary optic perineuritis are normally responsive, hence thorough differential diagnosis is necessary.
The Main Determinants of the Government Expenditure: A Case Study of Côte D’ivoire
Authors: Mohsen Adel Shakeeb 
Published: October 2023

Abstract
Based on the importance of government expenditure in supporting economic growth in the country, the main objective of this study is to investigate the determinants of government expenditure in Cote d’Ivoire over the period 1980-2020. To achieve the objective, this study examines the effect of external debt, national income, inflation, and population on government expenditure, by using the ADF unit root test, Johansen cointegration test, Granger causality test, and CUSUM test. Results from the Johansen cointegration test indicated that there are long-run relationships among the variables. Government expenditure is positively related to external debt, national income, and population, but it is negatively related to inflation. The population has the biggest effect on government expenditure. The Granger causality test shows that there is a unidirectional short-run causality relationship running from external debt to government expenditure, but there is no evidence of any short-run causality relationship between national income, inflation, population, and government expenditure. On the other hand, there are bidirectional long-run causality relationships between inflation, population, and government expenditure, and unidirectional long-run causality relationships running from external debt and national income to government expenditure in Côte d’Ivoire. Lastly, the CUSUM test indicated that there are no structural changes in the model. The study recommends that the government should use government expenditure more efficiently in improving the infrastructure and creating an attractive investment climate, as well as upgrading the quality of human capital by improving the education system, health services, and the standard of living.
Impacts of the Use of Brazilian Fauna and Flora in Food and Medicinal Use
Authors: Da Costa Matheus Gomes , Araújo Raiana Cristina Simião , Carvalho Aldenor de Sousa , Brito Eliete da Silva , Aguiar João Vitor Castro , Oliveira Rainara Ribeiro , Da Mata Raylane Rocha , De Almeida Ricardo Santos , Rocha Thiara Lopes 
Published: October 2023

Objective: To describe the main repercussions of the use of Brazilian fauna and flora for food and medicinal purposes.

Method: This is an integrative literature review with a descriptive and qualitative approach. Searches were conducted in the Virtual Health Library system of the Ministry of Health using the following descriptors: medicinal teas, phytotherapeutic medication, and medicinal plants. Initially, 415 results were found without filters, and after applying the filters, the number of studies reduced to 74. From these, the titles from the database search were read, resulting in a final sample of only 15 articles for qualitative synthesis.

Results and conclusion: Through the conducted searches, it was found that the use of plants as medicines dates back to prehistoric times when humans began to utilize nature to cure their illnesses. Currently, medicinal plants are widely used in different parts of the world and are important sources of new bioactive molecules that can be used in the development of new medicines, dietary supplements, and natural cosmetics.

Research implications: The study highlights the richness and diversity of Brazilian flora, emphasizing the importance of preserving these natural resources. This is crucial for the conservation of unique plant and animal species in Brazil.

Originality/value: The study emphasizes the need for policies for the preservation and sustainable use of Brazilian fauna and flora resources. This is essential to ensure the survival of these species and to provide safe and effective treatments for people.