bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergence of Mandal System in Anantapur District
Authors: Nagabhushana B 
Published: December 2023

The Mandal system, a pivotal administrative and political frame work in Andhra Pradesh has witnessed significant evolution since its inception. It explores the emergence of Mandal system in the state of Andhra Pradesh, tracing its historical roots, social – political significance, and transformative impacts. The Mandal system addressed the socio- economic disparities by implementing reservation system for historically disadvantaged communities. Mandal system become a catalyst for social justice and empowerment.
Peer support and psychedelics
Authors: Skiles Zachary , Dixon James R. , Friedrich Dan , Reed Donny , Stauffer Christopher S. 
Published: December 2023

LAY SUMMARYThe new practices of psychedelic-assisted psychotherapy and state-run psychedelic services need trained facilitators. This article aligns the role of peer support in both the psychedelic and the Veteran communities, displaying core competencies and current practices, while also highlighting further needs in training and supervision. Continued work with peer support in the legal facilitation of psychedelic experiences will deepen understanding of psychedelic peership (i.e., when someone with previous firsthand experience with psychedelics facilitates the psychedelic therapy session of another).
Tarihsel miras ve Özbek kimliğinin Özbekistan dış politikasının oluşumuna etkisi
Authors: YILMAZ Kadir Kürşat , DURAN Hasan 
Published: December 2023

Özbekistan dış politikasını etkileyen birçok faktörün ortaya konulması mümkün olsa da özellikle tarihsel miras ve Özbek kimliğinin oluşumunun üzerinde durulması gerekmektedir. Tarihsel miras bir milletin hafızası olarak gelecek planlarına yön vermektedir. Tarihsel süreçte yaşanmış olan zafer ve kahramanlıklara özlem duyulurken, yenilgi ve başarısızlıklardan ders alınmaktadır. Bu anlamda güçlü devlet yapısının varlığı Özbekistan’da mutlu ve güzel günleri hatırlatırken, güçlü devlet yapısının bozulduğu dönemler ise işgal ve yenilgileri hatırlatmaktadır.
1991 yılında SSCB’nin dağılmasıyla gerçekleşen bağımsızlık sonrası üzerinde durulan en önemli konulardan biri Özbek kimliğinin oluşturulmasıdır. Bu konu iç politika da olduğu gibi dış politikada da belirleyici bir role sahiptir. Özbek kimliğinin toprak esaslı ele alınması belirli problemlere neden olsa da özellikle komşu ülkelerde bulunan Özbeklerin dış politika aracı olarak kullanılmasının önlenmesi açısından olumludur. Özbekçenin yaygınlaştırılması politikaları ve bağımsız bir dış politika yürütme çabaları da Özbek kimliğinin oluşumuna katkı sağlamaktadır.
Tarihsel miras ve milli kimlik politikaları üzerinden Özbekistan dış politikasının değerlendirilmesi Özbekistan’ı daha anlaşılır kılacaktır. Dolayısı ile sadece dış politika kararları üzerinden değerlendirmeler yapmak yerine, etkili olan tarihsel miras ve milli kimlik oluşturma stratejisinin incelenmesi Özbek dış politikası hakkında daha isabetli analizler yapılmasını sağlayabilir.
Effect of E-PR-01 on non-specific low back pain in the adult population: A randomized, double-blind, placebo-controlled, parallel-group trial
Authors: Srivastava Shalini , Karvir Sagar , Girandola Robert N. 
Published: December 2023

BACKGROUND: Low back pain (LBP) has emerged as a major public health concern leading to significant work productivity loss and deterioration in the quality of life. OBJECTIVE: A randomized, double-blind, placebo-controlled parallel-group clinical trial was conducted to investigate the effect of E-PR-01, a proprietary blend of Vitex negundo leaves and zingiber officinale rhizome, in individuals with LBP. METHODS: Seventy-two individuals aged 18 to 60 years with LBP were randomized in a 1:1 ratio in either the E-PR-01 or placebo group. The participants were instructed to take 2 capsules/day of the study products in two divided doses for 30 days. The study outcomes were changes in functional activity, bending flexibility, pain intensity, work productivity, and sleep quality. The sustained effect of the study products was also evaluated on the pain and physical functioning for 7 days after stopping the product intake. The product’s safety was evaluated by adverse events reporting throughout the study. RESULTS: Compared to the placebo, the E-PR-01 demonstrated a statistically significant reduction in functional disability (mean RMQ score: -5.47 vs. -2.48), pain intensity (mean VAS score: -31.29 vs. -14.55) and improved bending flexibility (mean distance: -5.60 vs. -2.38 cm). In addition, a significant improvement in work productivity as well as sleep quality was also observed. In the E-PR-01 group, a statistically significant sustained effect was observed compared to the placebo for the pain intensity (p< 0.0005) and the functional activity (p< 0.0001) scores. No significant adverse event was reported in the study. CONCLUSION: E-PR-01 significantly improved low back pain and bending flexibility in adults without adverse effects. Moreover, the effect of E-PR-01 lasted 7 days after stopping the intervention.
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma
Authors: Attia Amany Selim , Hussein Samia , Sameh Hend , Khalil Amr , Waley Ahmad Barakat , Matar Ihab , Sameh Reham 
Published: December 2023

BACKGROUND: Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignancy. Histopathological examination is widely accepted as the gold standard test for the diagnosis of PTC. However, the histopathological examination sometimes can’t differentiate PTC from other thyroid diseases. Differentiating PTC from other thyroid diseases is essential for a therapeutic approach and prognosis. OBJECTIVES: The current study was performed to investigate the utility of TROP-2, SPL-2, and CXCL12 mRNA and protein expression in discriminating PTC from other thyroid diseases that mimic PTC. METHODS: The current study was performed on 75 cases of surgically resected thyroid glands. The cases were distributed in two groups: the PTC group and the non-PTC group. The PTC group consisted of 35 cases (25 patients of the classic PTC variant and 10 patients of the PTC follicular variant). The non-PTC group consisted of 40 cases (10 cases were multinodular goiter, 5 cases were Graves’ disease, 5 cases were Hashimoto thyroiditis, 15 patients were follicular adenoma (FA) and 5 cases were follicular carcinoma). TROP-2, SPL-2, and CXCL12 mRNA expression were estimated by qRT-PCR, and protein expression was estimated by immunohistochemistry. RESULTS: There were upregulated TROP-2, SPL-2, and CXCL12 mRNA and protein expressions in PTC compared to non-PTC ([Formula: see text] 0.001, for each). There was a statistically significant upregulation in the mRNA expression of the three genes among PTC cases with larger tumor sizes ([Formula: see text] 0.001, for each), those with tumor stages III and IV ([Formula: see text] 0.008, 0.002 and [Formula: see text] 0.001 respectively), and those with LN metastasis ([Formula: see text] 0.001, for each). Moreover, there was a statistically significant upregulation in CXCL-12 gene expression among PTC cases with extra-thyroid extension ([Formula: see text] 0.001). CONCLUSION: mRNA expression of TROP-2, SPL-2, and CXCL12 among PTC cases increased in larger tumor size, tumor stages III and IV, and LN metastasis. Moreover, there was an increase in CXCL-12 gene expression among PTC cases with extra-thyroid extension. Thus, TROP-2, SPL-2, and CXCL12 expressions could be possible diagnostic and prognostic markers in PTC.
Hong Kong–Macau Severe Hives and Angioedema Referral Pathway
Authors: Li Philip H. , Au Elaine Y. L. , Cheong Si-Leong , Chung Ling , Fan Ka I. , Ho Marco H. K. , Leung Agnes S. Y. , Chung Martin M. H. , Wong Jane C. Y. , Coelho Ricardo 
Published: December 2023

BackgroundUrticaria (defined as the presence of hives, angioedema, or both) can be caused by a variety of etiologies ranging from more common conditions such as chronic spontaneous urticaria (CSU) to rarer conditions such as hereditary angioedema (HAE). Specialist referral may be necessary in cases of severe urticaria or HAE, but access to specialist services remains limited in certain regions, such as the Greater Bay Area (GBA) of China. To address this, the Hong Kong–Macau Severe Hives and Angioedema Referral Pathway (SHARP) was initiated by the Hong Kong Institute of Allergy and Macau Society of Dermatology to promote multidisciplinary collaboration and regional exchange of expertise in the diagnosis and management of severe urticaria.MethodsA nominated task force of dermatologists and immunologists who manage patients with severe urticaria formulated the consensus statements (CS) using the Delphi method. The consensus was defined a priori as an agreement of ≥80%.ResultsA total of 24 CS were formulated, including four statements on classifications and definitions, seven statements on diagnosis, and 13 statements on management and referral. The definitions for acute/chronic urticaria and severe CSU were stated. Unnecessary investigations and inappropriate medications were discouraged. The characteristics and recommended approach to suspected bradykinergic angioedema were specified. Stepwise treatment options using second-generation antihistamines, omalizumab, or cyclosporin for patients with CSU were addressed, and the importance of access to HAE-specific medications was emphasized. Furthermore, an integrated referral pathway for patients with severe hives and angioedema was constructed.ConclusionThe SHARP provides guidance for the management and specialist referral of patients with severe hives and angioedema in Hong Kong and Macau.
Breast cancer is associated with coronary heart disease: a cross-sectional survey of NHANES 1999–2018
Authors: Dai Luyao , Li Ruoxuan , Hao Qian , Bao Yuanhang , Hu Liqun , Zhang Yaohui , Kang Huafeng , Wu Hao , Ma Xiaobin , Song Yafan 
Published: December 2023

BackgroundUnderstanding the correlation between female breast cancer (BC) and the prevalence of coronary heart disease (CHD) is important for developing prevention strategies and reducing the burden of female social disease. This study aimed to evaluate the relationship between BC and CHD using data from the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2018.MethodsThe study cohort included 16,149 eligible non-pregnant female participants aged 20 years or older. Logistic regression was used to analyze the relationship between BC and CHD, excluding the interaction between covariates and BC through hierarchical subgroup analysis.ResultsThe study found that participants with BC had a 2.30 times greater risk of developing CHD compared to those without BC [95% confidence interval (CI): 2.29–2.31]. After adjusting for all included covariates, BC was still significantly associated with CHD risk (odds ratio: 1.11, 95% CI: 1.10–1.12). When participants were stratified by age, education level, and prevalence of hypertension, it was evident that participants with BC had a higher risk of developing CHD compared to those without BC, although the effect of BC on CHD varied across stratification.ConclusionsOur study demonstrates the close relationship between CHD and female BC. Therefore, it is necessary to screen patients with CHD for BC and monitor BC survivors for the long-term risk of developing CHD.
Relationships between body composition, anthropometrics, and standard lipid panels in a normative population
Authors: Weeks Marcus , Delgado Andrew D. , Wood Jamie , Zhang Bodi , Pesce Sarah , Kunces Laura , Lili Loukia , Putrino David 
Published: December 2023

IntroductionMore than one third of adults in the United States (US) meet the clinical criteria for a diagnosis of metabolic syndrome, but often diagnosis is challenging due to healthcare access, costs and discomfort with the process and invasiveness associated with a standard medical examination. Less invasive and more accessible approaches to collecting biometric data may have utility in identifying individuals at risk of diagnoses, such as metabolic syndrome or dyslipidemia diagnoses. Body composition is one such source of biometric data that can be non-invasively acquired in a home or community setting that may provide insight into an individual's propensity for a metabolic syndrome diagnosis. Here we investigate possible associations between body composition, anthropometrics and lipid panels in a normative population.MethodsHealthy participants visited the Lab100 clinic location at a hospital setting in New York City and engaged in a wellness visit led by a nurse practitioner. Blood was analyzed at point-of-care using the Abbott Piccolo Xpress portable diagnostic analyzer (Abbott Laboratories, IL, USA) and produced direct measures of total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), very-low density lipoprotein (VLDL-C), and triglycerides (TG). Body composition and anthropometric data were collected using two separate pieces of equipment during the same visit (Fit3D and InBody570). Regression analysis was performed to evaluate associations between all variables, after adjusting for age, sex, race, AUDIT-C total score (alcohol use), and current smoking status.ResultsData from 199 participants were included in the analysis. After adjusting for variables, percentage body fat (%BF) and visceral fat levels were significantly associated with every laboratory lipid value, while waist-to-hip ratio also showed some significant associations. The strongest associations were detected between %BF and VLDL-C cholesterol levels (t = 4.53, p = 0.0001) and Triglyceride levels (t = 4.51, p = 0.0001).DiscussionThis initial, exploratory analysis shows early feasibility in using body composition and anthropometric data, that can easily be acquired in community settings, to identify people with dyslipidemia in a normative population.
netMUG: a novel network-guided multi-view clustering workflow for dissecting genetic and facial heterogeneity
Authors: Li Zuqi , Melograna Federico , Hoskens Hanne , Duroux Diane , Marazita Mary L. , Walsh Susan , Weinberg Seth M. , Shriver Mark D. , Müller-Myhsok Bertram , Claes Peter , Van Steen Kristel 
Published: December 2023

Introduction: Multi-view data offer advantages over single-view data for characterizing individuals, which is crucial in precision medicine toward personalized prevention, diagnosis, or treatment follow-up.Methods: Here, we develop a network-guided multi-view clustering framework named netMUG to identify actionable subgroups of individuals. This pipeline first adopts sparse multiple canonical correlation analysis to select multi-view features possibly informed by extraneous data, which are then used to construct individual-specific networks (ISNs). Finally, the individual subtypes are automatically derived by hierarchical clustering on these network representations.Results: We applied netMUG to a dataset containing genomic data and facial images to obtain BMI-informed multi-view strata and showed how it could be used for a refined obesity characterization. Benchmark analysis of netMUG on synthetic data with known strata of individuals indicated its superior performance compared with both baseline and benchmark methods for multi-view clustering. The clustering derived from netMUG achieved an adjusted Rand index of 1 with respect to the synthesized true labels. In addition, the real-data analysis revealed subgroups strongly linked to BMI and genetic and facial determinants of these subgroups.Discussion: netMUG provides a powerful strategy, exploiting individual-specific networks to identify meaningful and actionable strata. Moreover, the implementation is easy to generalize to accommodate heterogeneous data sources or highlight data structures.
Primary carnitine deficiency: Estimation of prevalence in Chinese population and insights into newborn screening
Authors: Ji Xiaoshan , Ge Yanzhuang , Ni Qi , Xu Suhua , Xiong Zhongmeng , Yang Lin , Hu Liyuan , Cao Yun , Lu Yulan , Wei Qiufen , Kang Wenqing , Zhuang Deyi , Zhou Wenhao , Dong Xinran 
Published: December 2023

Primary carnitine deficiency (PCD) caused by pathogenic variants in the solute carrier family 22 member 5 (SLC22A5) gene is a rare autosomal recessive disease that results in defective fatty acid oxidation. PCD can be detected through tandem mass spectrometry (MS/MS), but transplacental transport of free carnitine from mothers may cause false negatives or positives during newborn screening (NBS). This study aimed to analyze the genetic characteristics of SLC22A5 and estimate the prevalence of PCD in the Chinese population, providing useful information for NBS and genetic counseling. We manually curated SLC22A5 pathogenic or likely pathogenic (P/LP) variants according to the American College of Medical Genetics and Genomics (ACMG) guidelines and identified 128 P/LP variants. Based on the China Neonatal Genomes Project (CNGP), the estimated PCD prevalence was 1:17,456, which was higher than that in other populations. The genotype–phenotype association analysis showed that patients carrying homozygous c.760C&gt;T and c.844C&gt;T were more likely to present cardiomyopathy, whereas those carrying homozygous c.1400C&gt;G were more likely to be asymptomatic (all p-values &lt; 0.05). We found that there was no significant difference in initial C0 concentrations between patients and carriers, but there was a significant difference in the second-tier screening of C0 concentration between them (p-value &lt; 0.05). We established a cost-effective variant panel containing 10 high-frequency sites and developed a screening algorithm incorporating gene panels with MS/MS, which could rescue one more patient who was undetected from MS/MS. In conclusion, the prevalence of PCD in the Chinese population is relatively high. The combination of conventional NBS with genetic sequencing is suggested for early diagnosis of PCD.
Acupuncture combined with pelvic floor rehabilitation training for postpartum stress urinary incontinence: protocol for a systematic review and meta-analysis
Authors: Wenming Chu , Xiaoman Deng , Ling Gao , Yun Li , Xiyan Gao 
Published: December 2023

IntroductionThe purpose of this study is to systematically evaluate the efficacy and safety of acupuncture combined with pelvic floor rehabilitation training in the treatment of postpartum stress urinary incontinence, and to promote the further promotion and application of acupuncture in the field of rehabilitation.Methods and analysisRandomized controlled trials (RCTs) of acupuncture combined with pelvic floor rehabilitation in the treatment of postpartum stress urinary incontinence will be searched in PubMed, Web of Science (WOS), Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wanfang (WF), and VIP databases. The clinical trial Registry (ClinicalTrials.gov and Chinese clinical trial Registry) will also be searched. The search period is limited to July 1, 2023, and the language limit of this systematic review is Chinese and English. The primary outcome is clinical effective rate. International Consultation on Incontinence Questionnaire-Short Form (ICI-Q-SF), 1-h pad test, pelvic floor muscle potential value, incidence of adverse events are secondary outcomes. A meta-analysis will be performed using RevMan 5.4 statistical software. If feasible, subgroup analysis and sensitivity analysis will be performed to address potential causes of inconsistency and heterogeneity. The risk of bias will be assessed using the approach recommended by Cochrane Handbook for Systematic Reviews of Interventions, and the quality of evidence will be assessed using GRADE. This Protocol has been developed in accordance with the guideline of Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) 2015.DiscussionAcupuncture combined with pelvic floor rehabilitation training can effectively promote the rehabilitation of postpartum stress urinary incontinence patients, and provide a reference for the clinical application of integrated Chinese and Western medicine treatment in the field of rehabilitation.Systematic review registrationPROSPERO CRD42023455801.
Commonalities and distinctions between the type 2 diabetes mellitus and Alzheimer’s disease: a systematic review and multimodal neuroimaging meta-analysis
Authors: Xie Hao , Yu Ying , Yang Yang , Sun Qian , Li Ze-Yang , Ni Min-Hua , Li Si-Ning , Dai Pan , Cui Yan-Yan , Cao Xin-Yu , Jiang Nan , Du Li-Juan , Gao Wen , Bi Jia-Jun , Yan Lin-Feng , Cui Guang-Bin 
Published: December 2023

BackgroundAlzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are aging related diseases with high incidence. Because of the correlation of incidence rate and some possible mechanisms of comorbidity, the two diseases have been studied in combination by many researchers, and even some scholars call AD type 3 diabetes. But the relationship between the two is still controversial.MethodsThis study used seed-based d mapping software to conduct a meta-analysis of the whole brain resting state functional magnetic resonance imaging (rs-fMRI) study, exploring the differences in amplitude low-frequency fluctuation (ALFF) and cerebral blood flow (CBF) between patients (AD or T2DM) and healthy controls (HCs), and searching for neuroimaging evidence that can explain the relationship between the two diseases.ResultsThe final study included 22 datasets of ALFF and 22 datasets of CBF. The results of T2DM group showed that ALFF increased in both cerebellum and left inferior temporal gyrus regions, but decreased in left middle occipital gyrus, right inferior occipital gyrus, and left anterior central gyrus regions. In the T2DM group, CBF increased in the right supplementary motor area, while decreased in the middle occipital gyrus and inferior parietal gyrus. The results of the AD group showed that the ALFF increased in the right cerebellum, right hippocampus, and right striatum, while decreased in the precuneus gyrus and right superior temporal gyrus. In the AD group, CBF in the anterior precuneus gyrus and inferior parietal gyrus decreased. Multimodal analysis within a disease showed that ALFF and CBF both decreased in the occipital lobe of the T2DM group and in the precuneus and parietal lobe of the AD group. In addition, there was a common decrease of CBF in the right middle occipital gyrus in both groups.ConclusionBased on neuroimaging evidence, we believe that T2DM and AD are two diseases with their respective characteristics of central nervous activity and cerebral perfusion. The changes in CBF between the two diseases partially overlap, which is consistent with their respective clinical characteristics and also indicates a close relationship between them.Systematic review registrationPROSPERO [CRD42022370014].
Efficient and robust second-harmonic generation in thin-film lithium niobate using modal phase matching
Authors: Hansen Mikkel T. , Ulsig Emil Z. , Labbé Fabien , Madsen Magnus L. , Ding Yunhong , Rottwitt Karsten , Volet Nicolas 
Published: December 2023

A double-ridge waveguide is designed for efficient and robust second-harmonic generation (SHG) using the thin-film lithium-niobate-on-insulator (LNOI) platform. Perfect phase matching (PhM) is achieved between the fundamental waveguide mode at 1,550 nm and a higher-order mode at the second harmonic. The fabrication tolerances of the PhM condition are simulated using a finite-difference method mode solver, and conversion efficiencies as high as 3.92 W−1 are obtained for a 1-cm long waveguide. This design allows access to the largest element of the second-order nonlinear susceptibility tensor, and represents a scalable alternative to waveguides based on periodically-poled lithium niobate (PPLN). The design has the potential for generating pairs of entangled photons in the infrared C-band by spontaneous parametric down-conversion (SPDC).