bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrostatic chuck having compliant multi-beam structures with rotatable bipolar pad-shaped electrodes
Authors: Taoka Yuki , Ryo Tomohiro , Xu Sanchuan , Saito Shigeki 
Published: January 2024

Abstract
The demand for the manipulation of flexible film-like objects and those with non-planar surfaces, which cannot be handled using current technologies, has increased considerably. A bipolar electrostatic chuck (ESC) is a device that clamps target objects using a uniform electrostatic force. Traditional ESCs cannot satisfy these demands because of their planar surfaces. Bipolar ESCs with a compliant multi-beam assembly have been proposed to manipulate such objects while leveraging the uniform force distribution of ESCs. Although the proposed compliant ESCs have the potential for such manipulations, increasing the attractive force remains a critical technical issue. This study aims to develop a compliant ESC with pad-shaped bipolar electrodes connected to beam tips with rotational degrees of freedom (RDOFs). Four ESC models with pad-shaped electrodes with different RDOFs between zero and three and one without a pad-shaped electrode are fabricated via 3D printing. The experimental comparison of the five models indicates that an increase in the RDOFs significantly improves the attractive force of each electrode. The high potential of compliant ESCs with three RDOFs at the beam tips is illustrated using three different demonstrations: picking and placing dielectric films, a rigid object with a plane surface, and a rigid object with a curved surface. The results provide insights into the development of industrial electrostatic grippers.
A reproducible extrusion printing process with highly viscous nanoparticle inks
Authors: Ungerer Martin , Debatin Christian , Martel Joachim , Maurer Volker , Reichert Klaus-Martin , Hofmann Andreas , Gengenbach Ulrich 
Published: January 2024

Abstract
Printing of functional materials such as nanoparticle inks is a class of additive fabrication techniques complementary to standard subtractive electronics fabrication techniques such as pcb technology on pcb level or silicon based microelectronics on integrated circuit level. To date the majority of digital printing processes for (micro)electronics is inkjet based. Moreover aerosol jet based printing also establishes itself for printing on non-planar substrates and for materials with higher viscosities. A material deposition technique available since decades and mainly used for dispensing of adhesives and sealing materials is fluid-filament printing. It allows to cover a wide range of materials and viscosities and thus, also holds potential for additive manufacturing of electronics. In this paper we systematically study the influences on fluid filament printing both theoretically taking into account ink and equipment tolerances and experimentally using mainly standard dispensing equipment and two commercial screen printing inks. At the end of the paper we derive recommendations for reproducible printing of conductive lines and pads and give an outlook to printing 2.5D structures.
Measuring an artificial intelligence language model’s trust in humans using machine incentives
Authors: Johnson Tim , Obradovich Nick 
Published: January 2024

Abstract
Will advanced artificial intelligence (AI) language models exhibit trust toward humans? Gauging an AI model’s trust in humans is challenging because—absent costs for dishonesty—models might respond falsely about trusting humans. Accordingly, we devise a method for incentivizing machine decisions without altering an AI model’s underlying algorithms or goal orientation and we employ the method in trust games between an AI model from OpenAI and a human experimenter (namely, author TJ). We find that the AI model exhibits behavior consistent with trust in humans at higher rates when facing actual incentives than when making hypothetical decisions—a finding that is robust to prompt phrasing and the method of game play. Furthermore, trust decisions appear unrelated to the magnitude of stakes and additional experiments indicate that they do not reflect a non-social preference for uncertainty.
SeedMatchR: identify off-target effects mediated by siRNA seed regions in RNA-seq experiments
Authors: Cazares Tareian , Higgs Richard E , Wang Jibo , Ozer Hatice Gulcin 
Published: January 2024

Abstract

Motivation
On-target gene knockdown, using siRNA, ideally results from binding fully complementary regions in mRNA transcripts to induce direct cleavage. Off-target siRNA gene knockdown can occur through several modes, one being a seed-mediated mechanism mimicking miRNA gene regulation. Seed-mediated off-target effects occur when the ∼8 nucleotides at the 5’ end of the guide strand, called a seed region, bind the 3’ untranslated regions of mRNA, causing reduced translation. Experiments using siRNA knockdown paired with RNA-seq can be used to detect siRNA sequences with off-target effects driven by the seed region. However, there are limited computational tools designed specifically for detecting siRNA off-target effects mediated by the seed region in differential gene expression experiments.

Results
SeedMatchR is an R package developed to provide users a single, unified resource for detecting and visualizing seed-mediated off-target effects of siRNA using RNA-seq experiments. SeedMatchR is designed to extend current differential expression analysis tools, such as DESeq2, by annotating results with predicted seed matches. Using publicly available data, we demonstrate the ability of SeedMatchR to detect cumulative changes in differential gene expression attributed to siRNA seed region activity.

Availability
SeedMatchR is available on CRAN. Documentation and example workflows are available through the SeedMatchR GitHub page at https://github.com/tacazares/SeedMatchR.
Chronic High-Level Parasitemia in HIV–Infected Individuals With or Without Visceral Leishmaniasis in an Endemic Area in Northwest Ethiopia: Potential Superspreaders?
Authors: van Griensven Johan , van Henten Saskia , Kibret Aderajew , Kassa Mekibib , Beyene Hailemariam , Abdellati Saïd , de Hondt Annelies , Adriaensen Wim , Vogt Florian , Pareyn Myrthe , Ritmeijer Koert , Diro Ermias 
Published: January 2024

Abstract

Background
People with human immunodeficiency virus (PWH) with recurrent visceral leishmaniasis (VL) could potentially drive Leishmania transmission in areas with anthroponotic transmission such as East Africa, but studies are lacking. Leishmania parasitemia has been used as proxy for infectiousness.

Methods
This study is nested within the Predicting Visceral Leishmaniasis in HIV-InfectedPatients (PreLeisH) prospective cohort study, following 490 PWH free of VL at enrollment for up to 24–37 months in northwest Ethiopia. Blood Leishmania polymerase chain reaction (PCR) was done systematically. This case series reports on 10 PWH with chronic VL (≥3 VL episodes during follow-up) for up to 37 months, and 3 individuals with asymptomatic Leishmania infection for up to 24 months.

Results
All 10 chronic VL cases were male, on antiretroviral treatment, with 0–11 relapses before enrollment. Median baseline CD4 count was 82 cells/µL. They displayed 3–6 VL treatment episodes over a period up to 37 months. Leishmania blood PCR levels were strongly positive for almost the entire follow-up (median cycle threshold value, 26 [interquartile range, 23–30]), including during periods between VL treatment. Additionally, we describe 3 PWH with asymptomatic Leishmania infection and without VL history, with equally strong Leishmania parasitemia over a period of up to 24 months without developing VL. All were on antiretroviral treatment at enrollment, with baseline CD4 counts ranging from 78 to 350 cells/µL.

Conclusions
These are the first data on chronic parasitemia in PWH from Leishmania donovani–endemic areas. PWH with asymptomatic and symptomatic Leishmania infection could potentially be highly infectious and constitute Leishmania superspreaders. Xenodiagnosis studies are required to confirm infectiousness.
Funding and Resourcing Quality Improvement Effort in Infectious Diseases
Authors: Naureckas Li Caitlin , Jhaveri Ravi 
Published: January 2024

Abstract
Infectious diseases physicians are frequently called on to perform quality improvement and patient safety (QIPS) work. We describe a newly created faculty position at our institution that allows a faculty member with graduate training in quality and safety methodologies to address QIPS priorities at both the division and hospital levels.
High-resolution quantification of stress perfusion defects by cardiac magnetic resonance
Authors: Scannell Cian M , Crawley Richard , Alskaf Ebraham , Breeuwer Marcel , Plein Sven , Chiribiri Amedeo 
Published: January 2024

Abstract

Aims
Quantitative stress perfusion cardiac magnetic resonance (CMR) is becoming more widely available, but it is still unclear how to integrate this information into clinical decision-making. Typically, pixel-wise perfusion maps are generated, but diagnostic and prognostic studies have summarized perfusion as just one value per patient or in 16 myocardial segments. In this study, the reporting of quantitative perfusion maps is extended from the standard 16 segments to a high-resolution bullseye. Cut-off thresholds are established for the high-resolution bullseye, and the identified perfusion defects are compared with visual assessment.

Methods and results
Thirty-four patients with known or suspected coronary artery disease were retrospectively analysed. Visual perfusion defects were contoured on the CMR images and pixel-wise quantitative perfusion maps were generated. Cut-off values were established on the high-resolution bullseye consisting of 1800 points and compared with the per-segment, per-coronary, and per-patient resolution thresholds. Quantitative stress perfusion was significantly lower in visually abnormal pixels, 1.11 (0.75–1.57) vs. 2.35 (1.82–2.9) mL/min/g (Mann–Whitney U test P &lt; 0.001), with an optimal cut-off of 1.72 mL/min/g. This was lower than the segment-wise optimal threshold of 1.92 mL/min/g. The Bland–Altman analysis showed that visual assessment underestimated large perfusion defects compared with the quantification with good agreement for smaller defect burdens. A Dice overlap of 0.68 (0.57–0.78) was found.

Conclusion
This study introduces a high-resolution bullseye consisting of 1800 points, rather than 16, per patient for reporting quantitative stress perfusion, which may improve sensitivity. Using this representation, the threshold required to identify areas of reduced perfusion is lower than for segmental analysis.
Diabetes mellitus and presentation, care and outcomes of patients with NSTEMI: the Association for Acute Cardiovascular Care-European Association of Percutaneous Cardiovascular Interventions EURObservational Research Programme NSTEMI Registry of the European Society of Cardiology
Authors: Nadarajah Ramesh , Ludman Peter , Laroche Cécile , Appelman Yolande , Brugaletta Salvatore , Budaj Andrzej , Bueno Hector , Huber Kurt , Kunadian Vijay , Leonardi Sergio , Lettino Maddalena , Milasinovic Dejan , Ajjan Ramzi , Marx Nikolaus , Gale Chris P 
Published: January 2024

Abstract

Aims
Diabetes mellitus (diabetes) is common amongst patients with non-ST-segment elevation myocardial infarction (NSTEMI). We describe presentation, care, and outcomes of patients admitted with NSTEMI by diabetes status.

Methods and results
Prospective cohort study including 2928 patients (1104 with prior diabetes, 1824 without) admitted to hospital with NSTEMI from 287 centres in 59 countries. Quality of care was evaluated based on 12 guideline-recommended care interventions. Outcomes included in-hospital acute heart failure, cardiogenic shock, repeat myocardial infarction, stroke/transient ischaemic attack (TIA), BARC Type ≥ 3 bleeding and death, as well as 30-day mortality. Patients with diabetes had higher comorbidity burden and more frequently presented with Killip Class II–IV heart failure (10.2% vs. 3.7%, P &lt; 0.001), haemodynamic instability (7.1% vs. 3.7%, P &lt; 0.001), and ongoing chest pain (43.1% vs. 37.0%, P &lt; 0.001), than those without diabetes. Overall, care quality received was similar by diabetes status (60.0% vs. 60.5% received ≥ 80% of eligible care interventions, P = 0.786), but patients with diabetes experienced higher rates of in-hospital acute heart failure (15.3% vs. 6.8% P &lt; 0.001), cardiogenic shock (4.5% vs. 2.5%, P = 0.002), stroke/TIA (2.0% vs. 0.8%, P = 0.006), and death (2.5% vs. 1.4%, P = 0.022), and higher 30-day mortality (3.3% vs. 2.0%, P = 0.025). Of NSTEMI with diabetes, only 1.9% and 9.0% received prescription for glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors, respectively, on discharge, and only 45.9% were referred for cardiac rehabilitation.

Conclusion
NSTEMI patients with diabetes, compared with those without, present more clinically unwell and have worse outcomes despite receiving equal quality of care. Prescription of cardiovascular-protective glycaemic agents is an actionable target to reduce risk of further events.
Initial thickness of the crescent may not be a reliable predictor of complications in type A intramural haematoma
Authors: Kitamura Tadashi , Shikata Fumiaki , Torii Shinzo , Mishima Toshiaki , Fukuzumi Masaomi , Motoji Yusuke , Tamura Yoshimi , Kaneda Sakura , Ishiwaki Daiki , Miyaji Kagami 
Published: January 2024

Abstract

OBJECTIVES
This study aimed to investigate changes in haematoma thickness during the early period and their association with disease progression in patients who received initial medical treatment for type A intramural haematoma (IMH).

METHODS
Medical records and serial computed tomography angiography (CTA) images of patients who did not undergo emergency aortic repair for type A IMH upon presentation were retrospectively reviewed. The haematoma remodelling rate was determined using the following equation: thickness of the haematoma on the first CTA (mm) - thickness of the haematoma on the second CTA (mm)time between the first and second CTAs (h).

RESULTS
Among the 40 patients included in this study, 38 were indicated for initial watch-and-wait strategy, whereas 2 were indicated for emergency aortic repair but declined it. During hospitalization, 10 patients developed disease progression, with 2 in-hospital mortality cases. Analysis of the haematoma remodelling rate in 39 patients revealed that such a rate was significantly associated with the reciprocal of the time from onset. Analysis of all 70 CTA examinations performed within 24 h after the onset of IMH showed that haematoma thickness was significantly associated with the logarithm of the time from onset. Initial regression of the haematoma was not necessarily associated with avoidance of disease progression.

CONCLUSIONS
In type A IMH, the thickness of the haematoma in the ascending aorta tended to decrease in the very early period; however, prompt regression of the haematoma was not necessarily associated with avoidance of disease progression.
Performance and safety of temperature- and flow-controlled radiofrequency ablation for ventricular arrhythmia
Authors: Kobza Richard , Hilfiker Gabriela , Rissotto Sophie , Mahida Saagar , Grebmer Christian , Duru Firat , Pürerfellner Helmut , Berte Benjamin 
Published: January 2024

Abstract

Aims
High-power ablation is effective for ventricular arrhythmia ablation; however, it increases the risk of steam pops. The aim of this study was to define the safety and efficacy of QMODE ablation in the ventricle and the risk of steam pop.

Methods and results
Consecutive patients undergoing ventricular ablation using QDOT were included in a prospective single-centre registry. Procedural data, complications, and follow-up were systematically analysed and compared with a historical ventricular tachycardia (VT) and premature ventricular complexes (PVC) cohort ablated using STSF. QMODE (≤50 W) ablation was performed in 107 patients [age 62 ± 13 years; 76% male; VT (n = 41); PVC (n = 66)]. A total of 2456 applications were analysed [power: 45.9 ± 5.0 W with minimal power titration (90% &gt; 95% max power); duration 26 ± 8 s; impedance drop 9.4 ± 4.7 Ω; ablation index: 569 ± 163; mean–max temperature 44.3 ± 2.6°C]. Ventricular tachycardia ablation was associated with shorter radiofrequency (RF) time and a trend towards shorter procedure times using QDOT (QDOT vs. STSF: 20.1 ± 14.7 vs. 31 ± 17 min; P = 0.002, 151 ± 59 vs. 172 ± 48 min; P = 0.06). Complications, VT recurrence, and mortality rates were comparable (QDOT vs. STSF: 2% vs. 2%; P = 0.9, 24% vs. 27%; P = 0.82, and 2% vs. 4%; P = 0.67). Five audible steam pops (0.02%) occurred. Premature ventricular complex ablation was associated with comparable RF and procedure times (QDOT vs. STSF: 4.8 ± 4.6 vs. 3.9 ± 3.1 min; P = 0.25 and 96.1 ± 31.9 vs. 94.6 ± 24.7 min; P = 0.75). Complication and PVC recurrence were also comparable (QDOT vs. STSF: 0% vs. 3%; P = 0.17 and 19% vs. 22%; P = 0.71).

Conclusion
Ventricular ablation using QMODE ≤ 50 W is safe and effective for both VT and PVC ablation and is associated with a low risk for steam pop.
Arrhythmias including atrial fibrillation and congenital heart disease in Kleefstra syndrome: a possible epigenetic link
Authors: Vasireddi Sunil K , Draksler Tanja Zdolsek , Bouman Arianne , Kummeling Joost , Wheeler Matthew , Reuter Chloe , Srivastava Siddharth , Harris Jacqueline , Fisher Paul G , Narayan Sanjiv M , Wang Paul J , Badhwar Nitish , Kleefstra Tjitske , Perez Marco V 
Published: January 2024

Abstract

Aims
Kleefstra syndrome (KS), often diagnosed in early childhood, is a rare genetic disorder due to haploinsufficiency of EHMT1 and is characterized by neuromuscular and intellectual developmental abnormalities. Although congenital heart disease (CHD) is common, the prevalence of arrhythmias and CHD subtypes in KS is unknown.

Methods and results
Inspired by a novel case series of KS patients with atrial tachyarrhythmias in the USA, we evaluate the two largest known KS registries for arrhythmias and CHD: Radboudumc (50 patients) based on health record review at Radboud University Medical Center in the Netherlands and GenIDA (163 patients) based on worldwide surveys of patient families. Three KS patients (aged 17–25 years) presented with atrial tachyarrhythmias without manifest CHD. In the international KS registries, the median [interquartile range (IQR)] age was considerably younger: GenIDA/Radboudumc at 10/13.5 (12/13) years, respectively. Both registries had a 40% prevalence of cardiovascular abnormalities, the majority being CHD, including septal defects, vascular malformations, and valvular disease. Interestingly, 4 (8%) patients in the Radboudumc registry reported arrhythmias without CHD, including one atrial fibrillation (AF), two with supraventricular tachycardias, and one with non-sustained ventricular tachycardia. The GenIDA registry reported one patient with AF and another with chronic ectopic atrial tachycardia (AT). In total, atrial tachyarrhythmias were noted in six young KS patients (6/213 or 3%) with at least four (three AF and one AT) without structural heart disease.

Conclusion
In addition to a high prevalence of CHD, evolving data reveal early-onset atrial tachyarrhythmias in young KS patients, including AF, even in the absence of structural heart disease.
Age-Dependent Effects of Voluntary Wheel Running Exercise on Voiding Behavior and Potential Age-Related Molecular Mechanisms in Mice
Authors: Liu Teresa T , Pascal Laura E , Bauer Scott R , Miles Hannah N , Panksepp Jules B , Lloyd Granville L , Li Lingjun , DeFranco Donald B , Ricke William A 
Published: January 2024

Abstract

Background
Older men frequently develop lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). Risk factors for LUTS/BPH include sedentary lifestyle, anxiety/depression, obesity, and frailty, which all increase with age. Although physical exercise may reduce the progression and/or severity of LUTS/BPH, the age-related mechanisms responsible remain unknown.

Methods
Voiding symptoms, body mass, and frailty were assessed after 4-weeks of voluntary wheel running in 2-month (n = 10) and 24-month (n = 8) old C57Bl/6J male mice. In addition, various social and individual behaviors were examined in these cohorts. Finally, cellular and molecular markers of inflammation and mitochondrial protein expression were assessed in prostate tissue and systemically.

Results
Despite running less (aged vs young X¯ = 12.3 vs 30.6 km/week; p = .04), aged mice had reduced voiding symptoms (X¯ = 67.3 vs 23.7; p &lt; .0001) after 1 week of exercise, which was sustained through week 4 (X¯ = 67.3 vs 21.5; p &lt; .0001). Exercise did not affect voiding symptoms in young mice. Exercise also increased mobility and decreased anxiety in both young and aged mice (p &lt; .05). Exercise decreased expression of a key mitochondrial protein (PINK1; p &lt; .05) and inflammation within the prostate (CD68; p &lt; .05 and plasminogen activator inhibitor-1; p &lt; .05) and in the serum (p &lt; .05). However, a frailty index (X¯ = 0.17 vs 0.15; p = .46) and grip strength (X¯ = 1.10 vs 1.19; p = .24) were unchanged after 4 weeks of exercise in aged mice.

Conclusions
Voluntary aerobic exercise improves voiding behavior and mobility, and decreases prostatic mitochondrial protein expression and inflammation in aged mice. This promising model could be used to evaluate molecular mechanisms of aerobic exercise as a novel lifestyle intervention for older men with LUTS/BPH.
Ensemble Kalman inversion of induced polarization data
Authors: Tso Chak-Hau Michael , Iglesias Marco , Binley Andrew 
Published: January 2024

SUMMARY
This paper explores the applicability of ensemble Kalman inversion (EKI) with level-set parametrization for solving geophysical inverse problems. In particular, we focus on its extension to induced polarization (IP) data with uncertainty quantification. IP data may provide rich information on characteristics of geological materials due to its sensitivity to characteristics of the pore–grain interface. In many IP studies, different geological units are juxtaposed and the goal is to delineate these units and obtain estimates of unit properties with uncertainty bounds. Conventional inversion of IP data does not resolve well sharp interfaces and tends to reduce and smooth resistivity variations, while not readily providing uncertainty estimates. Recently, it has been shown for DC resistivity that EKI is an efficient solver for inverse problems which provides uncertainty quantification, and its combination with level set parametrization can delineate arbitrary interfaces well. In this contribution, we demonstrate the extension of EKI to IP data using a sequential approach, where the mean field obtained from DC resistivity inversion is used as input for a separate phase angle inversion. We illustrate our workflow using a series of synthetic and field examples. Variations with uncertainty bounds in both DC resistivity and phase angles are recovered by EKI, which provides useful information for hydrogeological site characterization. Although phase angles are less well-resolved than DC resistivity, partly due to their smaller range and higher percentage data errors, it complements DC resistivity for site characterization. Overall, EKI with level set parametrization provides a practical approach forward for efficient hydrogeophysical imaging under uncertainty.