bluuebunny/crossref_metadata_2025_split huggingface dataset:
Netupitant/palonosetron (NEPA) for prophylaxis of nausea and vomiting induced by chemotherapeutic conditioning before autologous stem cell transplantation
Authors: Akhmedov M. I. , Lunin V. V. , Khairullina L. S. , Cherkashina I. V. , Chervontseva A. M. , Vernyuk M. A. , Semochkin S. V. , Fedenko A. A. , Kaprin A. D. 
Published: January 2025

Background. Combination of 5-HT3-receptor inhibitors and NK1-inhibitors with dexamethasone and olanzapine is the standard-of-care measure for prevention of chemotherapy-induced nausea and vomiting in autologous hematopoietic stem cell transplant (auto-HCT) recipients.Aim. To assess the efficacy and toxicity of netupitant/palonosetron (NEPA) as monotherapy in the prevention of nausea and vomiting induced by pretransplant conditioning.Materials and methods. This prospective study included patients (n = 21) who underwent auto-HCT at the P.A. Herzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre. Patients with multiple myeloma were administered 1 capsule of NEPA 1 hour before conditioning, patients with lymphoma – 2 capsules: 1 hour before conditioning and 72 hours after the first dose of the drug. The primary endpoint was the complete response rate defined as no emesis and no rescue medication during the acute and delayed phases.Results. Complete response in the overall cohort was achieved in 81 % of patients both in the acute and delayed phases. In the high-dose melphalan group and LEAM-conditioning group (lomustine, etoposide, cytarabine, melphalan), the rates were also identical in the acute and delayed phases and were 75 and 88.9 %, respectively. Complete control in the entire cohort was achieved in 66.7 % during acute phase and 76.2 % during delayed phase. Corresponding rates in high-dose melphalan group were 66.7 and 75 %, respectively, and in LEAM-conditioning group – 66.7 and 77.8 %, respectively.Conclusion. NEPA monotherapy demonstrates high efficacy in auto-HCT recipients receiving highly-emetogenic pretransplant conditioning, while simplifying the antiemetic prophylaxis protocol as compared to four-drug-based regimens.
Multiple myeloma and anti-BCMA CAR-T therapy: a literature review
Authors: Faenko A. P. , Dudina G. A. , Mabudzade C. K. 
Published: January 2025

Significant progress has been made in the treatment of multiple myeloma (MM), leading to improved clinical outcomes. However, despite the success of traditional methods such as surgery, radiotherapy, and chemotherapy, the challenge of fully curing patients with relapsed and refractory MM remains pressing. A promising therapeutic approach is the use of chimeric antigen receptor T-cells (CAR-T), which has demonstrated efficacy in patients with resistant B-cell malignancies and is actively being studied for the treatment of MM. Special attention is being given to B-cell maturation antigen (BCMA) as a potential target for CAR-T therapy in MM.The objective is to analyze the current state of anti-BCMA CAR-T therapy in ММ, covering aspects of production, preclinical and clinical trials, as well as examining therapy-related toxicity and relapses.Data analysis was conducted using specialized medical databases such as PubMed, Scopus, Web of Science, Frontiers, and Google Scholar from 1974 to 2024. The article reviews latest achievements in CAR-T therapy for MM, current advances in the production and application of BCMA CAR T-cells, along with key challenges faced by this technology. The data obtained confirm significant progress in optimizing CAR T-cell structures and improving manufacturing processes, making the therapy more accessible for clinical use.Although early-phase trials of anti-BCMA CAR-T therapy show promising results, challenges remain, such as toxicity and insufficient response in some patients. Optimization of CAR structure and manufacturing technologies may improve the efficacy and accessibility of CAR T-cell therapy, making it a key direction for future research.
Reducing the Parameter Dependency of Phase-Picking Neural Networks with Dice Loss
Authors: Park Yongsoo , Beroza Gregory C. 
Published: January 2025

Abstract
Training a neural network for picking seismic phase arrivals has been commonly posed as a segmentation problem. It is a highly imbalanced segmentation problem in the sense that the background vastly dominates the foreground because we are trying to pick the optimal single sample point that represents the arrival of a seismic phase in a many seconds long time window. Here, we test the Dice loss, which is a preferred loss function for highly imbalanced image segmentation problems. We show that phase-picking neural networks trained on the Dice loss behave in a binary fashion for which the prediction output is almost always either nearly 1 or nearly 0. This feature removes the strong dependence of data processing workflows on the prediction score threshold, which is an otherwise critical parameter to determine when using neural networks trained on the cross-entropy loss. When strategically used, models trained on the Dice loss can reduce the parameter dependency of machine learning-based seismic monitoring.
Earthquake Recurrence Estimates for Northern Caribbean Faults from Combinatorial Optimization
Authors: ten Brink Uri S. , Geist Eric L. 
Published: January 2025

Abstract
We use combinatorial optimization to find the optimal spatial distribution of random samples of earthquakes (≥6.5) that minimize the misfit in target slip rates for all faults in the northeast Caribbean, and we derive magnitude–frequency relationships with uncertainties for these faults. Slip rates for many faults are derived from geodetic block models, not direct measurements, because of their underwater locations. Predicted recurrence rates for earthquakes on the East Hispaniola and Puerto Rico trench faults are 220–450 yr for moment magnitude (M) 7 and 3000–5000 yr for M 8, with the maximum feasible magnitude of M 8.2. The most frequent earthquakes with magnitudes ≥7.0 are predicted on the large upper plate strike-slip faults, Enriquillo (EF), and Septentrional faults, commensurate with the historical record. Calais et al. (2023) suggested that shortening in western Hispaniola is accommodated on the offshore Jérémie and onshore Malpasse faults north and south of EF, instead of on terrestrial faults in the western Hispaniola and EF. Because of our system-modeling approach, such a configuration predicts less frequent earthquakes on EF and western Hispaniola and Muertos convergent zones. Recurrence times of a few hundred years for M 6.7 earthquakes are predicted on the submerged faults in Mona Passage, and infrequent M &gt; 7 earthquakes are predicted on the Virgin Islands faults.
Engeramento e outras histórias: as narrativas orais no distrito de Barreira do Andirá
Authors: Nascimento Dilce Pio , Costa Érica Tridade , Curvelo Heloísa Reis 
Published: January 2025

Com esta pesquisa temos o intuito de discutir a cerca da literatura oral, mais precisamente a presença e a função sociocultural das narrativas orais nas comunidades ribeirinhas da Amazônia. Para isto, optou-se por uma pesquisa de campo, realizada através de entrevistas abertas, por meio da contação de histórias, com auxílio da História Oral, para coletar suas manifestações mais naturais, as variadas estórias disseminadas pelos mais velhos na comunidade de Barreira do Andirá, município de Barreirinha/AM, lugar de origem da família da pesquisadora. Os principais objetivos da referida pesquisa foram coletar narrativas orais de pessoas mais velhas, moradoras no Distrito de Barreira do Andirá com a finalidade de resgatar as narrativas orais que fazem parte da história da comunidade. A abordagem da pesquisa foi qualitativa, uma vez que a intenção deste trabalho não focou somente na coleta das narrativas, mas em entender a importância do ato de contar histórias, e quais elementos importantes estavam presentes em cada uma delas. A partir do que foi coletado, pôde-se conhecer mais sobre a construção histórico-cultural da região, assim como entender as influências da tecnologia no cotidiano daqueles sujeitos, e como essas narrativasorais estão sendo trabalhadas atualmente. O local onde se desenvolveu a coleta das narrativas, foi a comunidade de Barreira do Andirá, localizada em uma área fronteiriça entre os municípios de Parintins e Barreirinha, onde residem cerca de 206 famílias, compostas, principalmente por agricultores e pescadores. Os sujeitos da pesquisa foram cinco moradores do Distrito: Antônio Gonçalves Viana, Maria do Carmo, Moisés Viana, Paulo Sérgio dos Santos Trindade e Basílio Tenório. O critério para a escolha dessas pessoas, deu-se, primeiramente pela idade, pois a pesquisadora focou nas narrativas dos mais velhos moradores. Levou-se também em consideração o fato desses moradores pertencerem às famílias que protagonizaram a fundação daquele vilarejo. Os principais teóricos que embasaram esta pesquisa foram Ong (1998), Zumthor (1993 e 2000), Bosi (1979), Benjamim (1987), Cascudo (2006) e Freitas (2006).
Engaging Chemistry Learning: Combining Uno Flashcards And Assemblr Edu for Nomenclature Of Compound Material
Authors: Annisa Mutma’inna  , Mahartika Ira , Alfiah  , Pangoloan Soleman Ritonga  , Nofri Yuhelman  
Published: January 2025

Students nowadays are used to take the advantage of technological advances in their daily lives, especially for education. Thus, students prefer to learn with by the collaboration of the latest electronic media. Therefore, electronic media is a must for the learning process. The purpose of this study is to determine the level of validity and practicality of Uno flashcard learning media on Assemblr Edu-based application on nomenclature of compound materials. The type of the research is DDR (Design and Development Research) development model with the stages of analysis, design, and development. This research was conducted in 2 schools, SMA Cendana Pekanbaru and SMA IT Al-Fityah Pekanbaru. The data was collected by interviews and questionnaires. Then the data analyzed quantitatively and qualitatively. The validity level obtained from this product is 93% (very valid), while the level of practicality obtained by teachers is 95% (very practical), and the response rate from students is 90% (very practical). Based on these results, it can be concluded that the uno flashcard learning media based on Assemblr Edu application on nomenclature of compound material is very feasible and practical to use in the process of learning nomenclature of compound. The implication of this research is that it can provide new and innovative learning experiences to teachers and students.
PENDAMPINGAN PETANI DALAM PENINGKATAN KUALITAS BUAH MELON DENGAN TRICHODERMA DAN BIOCHAR DI KWT ALAMANDA, KELURAHAN PACCERAKKANG
Authors: Mantja Katriani , Dermawan Rahmansyah , Yanti Cri Wahyuni Brahmi , Dariati Tigin , Ridwan Ifayanti , Sulaeha Sulaeha , Nurfaida Nurfaida , Iswoyo Hari , Faried Muhammad 
Published: January 2025

Kelompok Wanita Tani (KWT) merupakan komponen pendukung ketahanan pangan di kota. Salah satunya yang berada di Kota Makassar, KWT Alamanda, belum memiliki pengetahuan dan keterampilan dalam memanfaatkan biochar pada budidaya tanaman di lahannya. Selain itu, pengetahuan terkait manfaat mikroba yang dapat membantu dalam meningkatkan ketahanan tanaman budidaya terhadap serangan penyakit terutama Trichoderma juga masih kurang dikalangan KWT mitra ini. Tujuan pengabdian pada masyarakat ini adalah sebagai transfer pengetahuan kepada mitra tentang penggunaan Biochar dan Trichoderma pada budidaya tanaman Melon. Metode yang digunakan pada kegiatan pengabdian ini adalah penyuluhan dan pelatihan dalam bentuk pendampingan budidaya Melon pada lahan KWT mitra. Selama kegiatan pengabdian, kelompok mitra secara aktif mengikuti penyuluhan dan pelatihan. Sebanyak 20 orang anggota KWT Alamanda mengikuti kegiatan ini. Pendampingan dilakukan pada semua tahapan budidaya melon menggunakan biochar dan Trichoderma yang dilaksanakan pada demonstration plot sejak persiapan lahan sampai panen. Dari kegiatan pengabdian dapat disimpulkan bahwa terjadi peningkatan pengetahuan dan keterampilan mitra sebesar 25% dalam melakukan budidaya tanaman melon yang diindikasikan oleh hasil pre-test dan post-test.
ABSTRACT
Women Farmers Group (KWT) is a supporting component of food security in the city. One of the KWTs in Makassar City, KWT Alamanda, does not have the knowledge and skills to utilize biochar in cultivating crops on their land. In addition, knowledge related to the benefits of microbes that can help increase the resistance of cultivated plants to disease attacks, especially Trichoderma, is still lacking among these KWT partners. The purpose of this community service is to transfer knowledge to partners about the use of Biochar and Trichoderma in Melon crop cultivation. The method used in this community service activity is counseling and training in the form of Melon cultivation assistance on the KWT partner's land. The partner group actively participated in counseling and training during the service activities. A total of 20 members of KWT Alamanda participated in this activity. Assistance is carried out at all stages of melon cultivation using biochar and Trichoderma, which are carried out on demonstration plots from land preparation to harvest. From the service activities, it can be concluded that partners' knowledge and skills increased by 25% in cultivating melon plants, as indicated by the pre-test and post-test results.
Keywords: Melon, KWT, Biochar, Trichoderma.
PELATIHAN PRODUKSI KERIPIK SINGKONG DAN TEPUNG TAPIOKA KEPADA PEMUDA DESA WAIJARANG LEMBATA
Authors: Tukan Gerardus Diri , Bria Kristina , Wokal Monika Woli , Seran Sefriani Vidiani Luruk , Snoe Arkhangela Giriani , Matilda Oktaviana , Boikh Ananda Oky Mekel M. , Costa Silvestra Intan Nahak , Lasar Maria Wilhelmina , Tukan Gerardus Diri 
Published: January 2025

Desa Waijarang, Kabupaten Lembata berdiri tahun 1995 dan menjadi lokasi relokasi bagi pengungsi. Masyarakat dominan sebagai petani dan menggarap lahan milik warga desa lain untuk berkebun. Desa Waijarang kini menjadi satu pintu masuk kabupaten Lembata dari jalur laut, karena terdapat pelabuhan kapal Fery, dan merupakan satu potensi bisnis. Namun, para pemuda desa kurang memiliki pengetahuan dan keterampilan untuk berwirausaha di bidang makanan dari hasil pertanian, seperti produk makanan camilan. Berdasarkan kondisi tersebut dilakukan pelatihan produksi keripik singkong dan tepung tapioka. Metode kegiatan yaitu praktek produksi. Hasil kegiatan yang dilaksanakan selama dua minggu yakni diproduksi keripik singkong dari singkong parutan. Para pemuda terlibat aktif. Evaluasi kegiatan dilakukan setiap akhir pekan. Luaran yang dihasilkan yakni produk keripik berlogo Kingkong Waijar dan tepung tapioka. Peserta pelatihan serta pemerintah desa menyatakan gembira karena memperoleh pengetahuan dan inovasi baru tentang pengolahan singkong segar. Disimpulkan bahwa kegiatan pelatihan berhasil dilakukan dan produk langsung dipasarkan.
ABSTRACT
Waijarang Village, Lembata Regency was established in 1995 and became a relocation location for refugees. The dominant community is farmers and works on land belonging to other villagers for gardening. Waijarang Village is now the entrance to Lembata Regency from the sea route, because there is a ferry port, and has business potential. However, village youth lack the knowledge and skills to become entrepreneurs in the field of food from agricultural products, such as snack food products. Based on these conditions, training was carried out on the production of cassava chips and tapioka flour. The activity method is production practice. The results of the activities carried out for two weeks were the production of cassava chips from grated cassava. The youth are actively involved. Evaluation of activities is carried out every weekend. The products produced are chips with the Kingkong Waijar logo and tapioka flour. The training participants and the village government expressed happiness because they had gained new knowledge and innovation about processing fresh cassava. It was concluded that the training activities were successful and the product was immediately marketed.
Keywords: Kingkong waijar, Waijarang Village youth, production training.
PELATIHAN TEKNOLOGI BUDIDAYA LADA PERDU DI PEKARANGAN PADA KELOMPOK WANITA DI DESA PADANGLAMPE PANGKEP
Authors: Syam Netty , Nurliani Nurliani , Jabir Sitti Rahmah , Hidrawati Hidrawati 
Published: January 2025

Pesantren Darul Mukhlisin milik Universitas Muslim Indonesia (UMI) yang ada di Desa Mitra Binaan Desa Padanglampe memiliki lahan yang sebahagian digunakan untuk tanaman lada sejak tahun 2015. Populasi lada sekitar 800 pohon dan sudah beberapa kali dipanen. Pengembangan lada oleh masyarakat di sekitar pesantren terkendala oleh adanya musim kering yang panjang di Desa Padanglampe yang berlangsung selama ≥ 6 bulan. Upaya pengembangan lada dilakukan dengan Program Pemberdayaan kelompok wanita untuk membangun daya, mendorong motivasi, membangkitkan kesadaran akan potensi yang dimilikinya dan berusaha untuk mengembangkannya. Metode yang digunakan berupa metode pelatihan partisipatif, yaitu melibatkan sebanyak mungkin peran serta mitra dalam kegiatan ceramah, diskusi, dan praktek pendampingan teknologi dan cipta karya. Teknologi yang diberikan pada mitra berupa Pembibitan lada perdu dan metode penanaman bibit ke planterbag di pekarangan. Pelaksanaan kegiatan Pelatihan dan pendampingan sudah dilaksanakan melalui transfer teknologi pada Aspek produksi Mitra sangat antusias dan berpartisipasi sangat aktif dalam semua kegiatan pelatihan dan pendampingan.
ABSTRACT
Darul Mukhlisin Islamic Boarding School owned by the Indonesian Muslim University (UMI) located in the Partner Village of Padanglampe Village has land that has been partly used for pepper plants since 2015. The pepper population is around 800 trees and has been harvested several times. The development of pepper by the community around the Islamic boarding school is hampered by the long dry season in Padanglampe Village which lasts for ≥ 6 months. Efforts to develop pepper are carried out through the Women's Group Empowerment Program to build power, encourage motivation, raise awareness of their potential, and strive to produce it. The method used is a training method and community mentoring through active partner participation. The technology provided to partners is in the form of pepper shrub nurseries and a method of planting seeds in planter bags in the yard. Training and mentoring activities have been carried out through technology transfer in the production aspect. Partners are enthusiastic and participate actively in all training and mentoring activities.
Keywords: Shrubs pepper, group empowerment, Padanglampe Village.
BIOKONVERSI LIMBAH PABRIK TEH DALAM MENINGKATKAN PENDAPATAN USAHA PRODUKSI PUPUK ORGANIK PADA PT. MADINA ANEKA SUBUR
Authors: Haruna Harsani , Poleuleng Andi Besse , Hala Dian Magfirah , Nurnawati Andi Ayu , Indriani Susi , Rasbawati Rasbawati , Fajri Syarif Al , Mutmainna Mutmainna , Servianti Servianti , Yusbasari Yuki , Para’pean Yulius Tina’ 
Published: January 2025

Proses pembuatan pupuk organik oleh PT Madina Aneka Subur memanfaatkan limbah pabrik teh berupa ampas sebagai bahan baku pupuk organik. Limbah ampas teh merupakan bahan organik dan memiliki berbagai macam kandungan. Masih awamnya pemahaman mengenai Maggot yang meliputi manfaat dan cara budidaya Maggot sehingga jarang yang memanfaatkan Maggot sebagai pengurai bahan organik. Pelatihan dan pendampingan ini bertujuan untuk meningkatkan pemahaman PT Madina Aneka Subur dalam mengelola limbah pabrik teh dalam meningkatkan pendapatan usaha produksi pupuk. Metode pelaksanaan pelatihan dilakukan dengan cara ceramah serta diskusi, sedanngkan pendampingan dilakukan dengan cara praktek di lokasi PT Madina Aneka Subur. Hasil kegiatan menjunukkan semangat dan antusias dari PT Madina Aneka Subur yang ingin memahami lebih lanjut proses pengolahan dengan memanfaatkan Maggot. Hal ini ditunjukkan pada saat kegiatan lanjutan berupa pendampingan budidaya Maggot. Kegiatan pelatihan dan pendampingan biokonversi limbah pabrik teh dengan memanfaatkan maggot berlangsung lancar dan sukses serta pemahaman peserta dari PT Madina Aneka Subur meningkat terkait pengolahan limbah pabrik teh dengan budidaya Maggot
Successful Healing After Minimally Invasive Subtalar Fusion Following Comminuted Open Calcaneus Fracture
Authors: Ranganathan Noopur , Aslan Lercan , Raza Marium , Miller Christopher P. 
Published: January 2025

Case:
A 51-year-old male polytrauma patient presented with bilateral calcaneus fractures after a fall. This report describes treatment of his right comminuted Sanders IV calcaneus fracture with percutaneous open reduction internal fixation (ORIF) and minimally invasive surgery (MIS) primary subtalar fusion to restore alignment and preserve soft tissue.

Conclusion:
Unlike traditional open approaches, which are prone to wound complications due to larger incisions, our approach of maintaining fracture alignment during joint preparation using an MIS burr for acute posttrauma subtalar arthrodesis and percutaneous ORIF appears to have reduced these risks, resulting in successful radiological healing and functional recovery at 1-year follow-up.
High-resolution, Wide-frequency-range Magnetic Spectroscopy with Solid-state Spin Ensembles
Authors: Walsworth Ronald , Yin Zechuan , Welter Justin , Hart Connor , Petruzzi Paul 
Published: January 2025

Abstract

Quantum systems composed of solid-state electronic spins can be sensitive detectors of narrowband magnetic fields. A prominent example is the nitrogen-vacancy (NV) center in diamond, which has been employed for magnetic spectroscopy with high spatial and spectral resolution. However, NV-diamond spectroscopy protocols are typically based on dynamical decoupling sequences, which are limited to low-frequency signals (≲ 20 MHz) due to the technical requirements on microwave (MW) pulses used to manipulate NV electronic spins. In this work, we experimentally demonstrate a high-resolution magnetic spectroscopy protocol that integrates a quantum frequency mixing (QFM) effect in a dense NV ensemble with coherently averaged synchronized readout (CASR) to provide both a wide range of signal frequency detection and sub-Hz spectral resolution. We assess the sensitivity of this QFM-CASR protocol across a frequency range of 10 MHz to 4 GHz. By measuring the spectra of multi-frequency signals near 0.6, 2.4 and 4 GHz, we demonstrate sub-Hz spectral resolution with a nT-scale noise floor for the target signal, and precise phase measurement with error <1°. Compared to state-of-the-art NV-diamond techniques for narrowband magnetic spectroscopy, the QFM-CASR protocol greatly extends the detectable frequency range, enabling applications in high-frequency radio frequency (RF) and MW signal microscopy and analysis, as well as tesla-scale nuclear magnetic resonance (NMR) spectroscopy of small samples.