bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dapagliflozin Alleviates Myocardial Ischaemia Reperfusion Injury by
Activating Mitophagy via the AMPK-PINK1/Parkin Signalling Pathway
Authors: Zuo Wei , Wang Liang , Tian Ran , Wang Lun , Liu Yifan , Qian Hao , Yang Xinglin , Liu Zhenyu 
Published: December 2023

Introduction::
Myocardial ischaemia reperfusion injury (MIRI) determines infarct size and
long-term outcomes after acute myocardial infarction (AMI). Dapagliflozin, a sodium-glucose cotransporter
2 inhibitor, alleviates MIRI in animal models.

Method::
We investigated the potential mechanisms underlying the cardioprotective effect of dapagliflozin
against MIRI, focusing on mitochondrial injury and mitophagy. MIRI mouse and H9C2 cell
models were established.

Results::
2,3,5-Triphenyltetrazolium chloride (TTC) staining showed a significant alleviation of MIRI
after pre-treatment of dapagliflozin compared to the model group (14.91 ± 1.76 vs. 40.47 ± 3.69%).
Data from the pre-treatment dapagliflozin group showed a significant decrease in left ventricular
ejection fraction (LVEF) (44.8 ± 2.7 vs. 28.5 ± 5.3%, P<0.01), left ventricular end-diastolic volume
(LVEDV) (70.6 ± 9.5 vs. 93.5 ± 13.8 ul, P<0.05), and left ventricular end-systolic volume (LVESV)
(39.0 ± 8.3 vs. 67.9 ± 13.7 ul, P<0.05) compared to the model group. Dapagliflozin also reduced the
levels of reactive oxygen species (ROS) and fragmented mitochondrial DNA, reversed the decrease
in mitochondrial membrane potential, and suppressed apoptosis. Further study showed that dapagliflozin
could protect against mitochondrial injury by rapidly clearing damaged mitochondria via mitophagy
in a phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1)/parkindependent
manner. Dapagliflozin regulated mitophagy in cardiomyocytes by suppressing the adenosine
5’monophosphate-activated protein kinase (AMPK)-PINK1/parkin signalling pathway, resulting
in attenuated MIRI.

Conclusion::
Dapagliflozin alleviated MIRI by activating mitophagy via the AMPK-PINK1/parkin
signalling pathway.
Potential Indications of Dupilumab in Th-2 Inflammatory Disease
Authors: Ilaria Proietti , Nevena Skroza , Ersilia Tolino , Nicoletta Bernardini , Federica Trovato , Di Fraia Marco , Agniezska Dybala , Concetta Potenza 
Published: December 2023

Abstract:
Dupilumab is a fully humanized IgG4 monoclonal antibody, inhibiting IL-4 and IL-13
signaling, which are the main cytokines involved in type 2 inflammatory diseases. Its
introduction was a breakthrough in the treatment of moderate-to-severe atopic dermatitis, but it is
also used in other inflammatory diseases, including asthma, eosinophilic esophagitis and chronic
rhinosinusitis with nasal polyposis. Recent advances in the understanding of inflammatory
pathways have revealed that Th2-type inflammation is involved in a wider range of diseases than
previously thought. The aim of our review is to examine off-label therapeutic indications of
dupilumab, including bullous dermatoses (pemphigus, bullous pemphigoid) and alopecia areata,
and to investigate its potential applications in cancer patients on anti-PD1 therapy.
Characterizing Longitudinal Patterns in Cognition, Mood, And Activity in Depression With 6-Week High-Frequency Wearable Assessment: Observational Study
Authors: Cormack Francesca , McCue Maggie , Skirrow Caroline , Cashdollar Nathan , Taptiklis Nick , van Schaik Tempest , Fehnert Ben , King James , Chrones Lambros , Sarkey Sara , Kroll Jasmin , Barnett Jennifer H 
Published: December 2023

Background
Cognitive symptoms are an underrecognized aspect of depression that are often untreated. High-frequency cognitive assessment holds promise for improving disease and treatment monitoring. Although we have previously found it feasible to remotely assess cognition and mood in this capacity, further work is needed to ascertain the optimal methodology to implement and synthesize these techniques.

Objective
The objective of this study was to examine (1) longitudinal changes in mood, cognition, activity levels, and heart rate over 6 weeks; (2) diurnal and weekday-related changes; and (3) co-occurrence of fluctuations between mood, cognitive function, and activity.

Methods
A total of 30 adults with current mild-moderate depression stabilized on antidepressant monotherapy responded to testing delivered through an Apple Watch (Apple Inc) for 6 weeks. Outcome measures included cognitive function, assessed with 3 brief n-back tasks daily; self-reported depressed mood, assessed once daily; daily total step count; and average heart rate. Change over a 6-week duration, diurnal and day-of-week variations, and covariation between outcome measures were examined using nonlinear and multilevel models.

Results
Participants showed initial improvement in the Cognition Kit N-Back performance, followed by a learning plateau. Performance reached 90% of individual learning levels on average 10 days after study onset. N-back performance was typically better earlier and later in the day, and step counts were lower at the beginning and end of each week. Higher step counts overall were associated with faster n-back learning, and an increased daily step count was associated with better mood on the same (P<.001) and following day (P=.02). Daily n-back performance covaried with self-reported mood after participants reached their learning plateau (P=.01).

Conclusions
The current results support the feasibility and sensitivity of high-frequency cognitive assessments for disease and treatment monitoring in patients with depression. Methods to model the individual plateau in task learning can be used as a sensitive approach to better characterize changes in behavior and improve the clinical relevance of cognitive data. Wearable technology allows assessment of activity levels, which may influence both cognition and mood.
INFLUENCE OF GOOD CORPORATE GOVERNANCE TOWARDS COMPANY VALUE WITH PROFITABILITY AS INTERVENING VARIABLE IN MANUFACTURING COMPANIES
Authors: Manik Florentia Tiurma Puspita , Purwanto Purwanto 
Published: December 2023

Good corporate governance and profitability are efforts to increase company value. The company was established to increase the company value to provide prosperity for the owners or shareholders. This study aims to determine the effect of corporate governance on company value with profitability as an intervening variable in manufacturing industries in manufacturing companies. The data research is taken from the financial reports of 19 selected companies on the Indonesia Stock Exchange for 2015-2020 using quantitative research. The independent variables are proxied by institutional ownership, audit committee, managerial ownership, independent Board of Commissioners, and Board of Director. Return on equity is a proxy of the profitability as an intervening variable and Tobin's q as a dependent variable. The method of data analysis used in this research is multiple linear regression analysis using statistical software. The data results show that the independent Board of commissioners and directors significantly influences ROE. The other three variables are not significant in predicting ROE. The audit committee and independent panel of commissioners do not affect the company's value.
On the other hand, company value is affected by institutional ownership, managerial ownership, and the Board of directors. Those five variables of good corporate governance and ROE simultaneously effectively predict company value with a 75.17% contribution. Profitability mediates the relation between good corporate governance and company value.
LIVING AL-QUR'AN DALAM RUANG POLITIK
Authors: Alif Muhtarul 
Published: December 2023

Artikel ini bertujuan untuk melacak tradisi memasukkan ayat Al-Qur’an ke dalam simbol politik. Studi Living Al-Qur’an mempelajari bagaimana Al-Qur’an mempengaruhi dan dipengaruhi oleh pemahaman masyarakat. Namun, jarang ada kajian Living Al-Qur’an dalam ranah politik, padahal ranah politik merupakan kekuatan yang sangat besar dalam mempengaruhi massa. Bendera Pusaka Jayakarta merupakan simbol perlawanan bangsa Indonesia yang memuat ayatayat Al-Qur’an. Penelitian ini akan menyingkap apa maksud internalisasi ayat tersebut, bagaimana ayat tersebut merespon dan direspon oleh masyarakat pada kala itu, serta menjelaskan pentingnya nilai-nilai Al-Qur’an dalam kehidupan sosial. Adapun metode yang digunakan dalam artikel ini adalah metode kualiatif dengan pendekatan semiotika C.S. Pierce. Hal ini dikarenakan setiap bendera memiliki makna dan filosofi yang dipercayai oleh penggunanya. Objek observasi dalam penelitian adalah bendera pusaka Jayakarta dengan dukungan referensi dari berbagai literatur. Hasil penelitian ini adalah Bendera Pusaka Jayakarta memiliki sembilan bagian yang mencirikan nilai Islam. Surah al-Ikhlas mencerminkan ketauhidan, Surah al-An'am/6: 103 menguatkan keyakinan, Basmalah meminta keberkahan, Surah as-Saff/61: 13 sebagai pemacu semangat. Hasil penelitian ini diharapkan dapat memberikan sudut pandang baru dalam kajian Living Al-Qur’an serta mengetahui nilai yang menjadi inspirasi perjuangan masyarakat.
NUKILAN AL-QUR’AN DALAM NASKAH TAREKAT SYEKH H. ALI IMRAN HASAN RINGAN-RINGAN (2017-1926)
Authors: Zakirman Zakirman , Mahmudi Elva , Bary Shafwatul 
Published: December 2023

Penelitian ini adalah sebuah upaya menelisik lebih jauh tentang khazanah ulama nusantara dalam proses transmisi ilmu-ilmu agama Islam. Objek utama penelitian dalam studi pustaka ini adalah naskah tulis tangan Syekh Ali Imran Hasan. Datanya diperoleh dari wawancara mendalam dengan sumber-sumber kredibel yang dipilih secara purposive dan dianalisa secara kualitatif. Adapun fokus utama yang jadi angel research dalam penelitian atas manuskrip ini adalah aspek Al-Qur’an yang cukup unik di dalamnya. Beberapa ayat Al-Qur’an dikutip dan dijelaskan sedemikian rupa dalam ranah penafsiran esoterik ala kaum sufi lazimnya. Selain itu, beberapa ayat Al-Qur’an dituliskan ulang dalam bentuk pola-pola tertentu yang masing-masingnya memiliki makna-makna filosofis guna mencapai maksud-maksud tertentu dalam proses bertarekat. Teori yang digunakan dalam menganalisa teks-teks yang termaktub dalam naskah tersebut adalah pendekatan hermeneutika ala Jorge Gracia di mana dalam menganalisa teks dibutuhkan dua sub-teori umum yaitu; meaning function dan implicative function. Hasil penelitian ini menunjukkan bahwa persentuhan ulama Nusantara dengan Al-Qur’an yang diinterpretasikan sebagimana horizon mereka masingmasing mengalami dinamika yang cukup variatif, bahkan berbeda dari penafsiran ala ulama klasik yang terkesan tunggal dan normatif.
PENERJEMAHAN RAMAH DIFABEL
Authors: Parwanto Wendi , 'Afifah Farida Nur 
Published: December 2023

Dalam Al-Qur’an dan Terjemahannya Edisi Penyempurnaan 2019 (QTK Edisi 2019) yang diterbitkan oleh Kemenag masih ditemukan sejumlah ayat difebal yang belum diterjemahkan dengan penerjemahan ramah difabel. Padahal saat peluncuran QTK Edisi penyempurnaan 2019 dijelaskan bahwa QTK edisi 2019 ini sudah mengakomodir terjemahan yang responsif dan ramah difabel. Dengan demikian, maka studi ini perlu dilakukan untuk menjelaskan bagaiamana terjemahan yang ‘dianggap’ ramah difabel oleh Kemenag. Kajian ini adalah jenis kajian kepustakaan, menggunakan metode deskriptif-analitis, serta menggunakan teori penerjemahan Peter Newmark. Kesimpulan studi ini menjelaskan bahwa: Pertama, penerjamahan ayat-ayat difabel fisik dan mental dalam QTK edisi 2019 cenderung belum konsisten. Kedua, masih diperlukan catatan tambahan untuk memahamkan pembaca, khususnya pada penekananan informasi ayat yang berindikasi difabel, sehingga tidak menimbulkan kesalahpahaman. Ketiga, dalam penerjemahan masih bertendesi pada konteks ayat, padahal susunan diksi dan kalimat juga perlu diperhatikan untuk menciptakan penerjemahan yang ramah difabel. Keempat, belum ada barometer yang jelas dalam QTK edisi 2019 khususnya pada penerjemahan yang ‘dianggap’ ramah difabel.
Comparison of Different Ultrafiltration Devices for the Study of Plasma Protein Binding of Carvedilol
Authors: Toma Camelia-Maria , Farczádi Lénárd , Ion Valentin , Muntean Daniela-Lucia , Imre Silvia 
Published: December 2023

Abstract
The aim of the present study was to assess the suitability of different Amicon Ultra and Centrifree ultrafiltration devices for the study of the plasma protein binding process in the case of carvedilol, a highly protein-bound and lipophilic beta-blocking agent. Samples at different levels of concentration were prepared in both proteic and non-proteic matrices (human plasma, 5% human serum albumin solution and saline solution) and subjected to the classical ultrafiltration method using the different devices considered. Furthermore, an attempt to apply a previously described modified ultrafiltration method was also made. The analysis and quantification was achieved using a validated LC-MS/MS method. For the Centrifree devices, the determined unbound fractions of carvedilol and the corresponding binding degree were in accordance to literature data, while for the Amicon Ultra devices a great degree of carvedilol adsorbtion to the sample reservoir was observed, the analyte not being detected in the ultrafiltrate samples. Thus, it was further demonstrated that the type of ultrafiltration device used has a significant influence on the outcome of a plasma protein binding study. In the case of carvedilol, the evaluation of the protein binding interaction could be achieved using the Centrifree ultrafiltration devices, but not the Amicon Ultra devices.
Liverworts and Mosses from Romania with Medicinal Potential
Authors: Costică Mihai , Stratu Anisoara , Costică Naela 
Published: December 2023

Abstract
Liverworts and mosses are terrestrial plants that contain biologically active substances that give them important medicinal qualities. After reviewing the available literature on the pharmacological activity of the most used liverworts and mosses, we present 34 species found in Romania, used for the treatment of common diseases in folk medicine around the world. Their uses in traditional medicine are sometimes confirmed by pharmacological research, especially external ones (as antimicrobial or cytotoxic remedies). The species of liverworts and mosses are mentioned with their distribution in Romanian flora and the habitats where they live.
Intercultural Bilingual Education (EIB) in Peru
Authors: Liñán Hugo Flores , Sano Jonasa Gamarra , Paucar Carmen Justina Mamani , Tafur Llasmin Vilcarromero 
Published: December 2023

Abstract
The article presents characteristics of the curriculum for the Regular Basic Education in Peru which addresses initial, primary, and secondary education. The curriculum takes into account that the country is home to diverse indigenous communities with different languages who are a prominent part of the society. As a consequence, intercultural bilingual education was implemented in many areas, and it is practiced mostly in a rural context. Short interviews with teachers show specific challenges of the bilingual class and underpin the importance of integrating the daily environment of the students in mathematics and science classes.
Eco-enzyme and mushroom bag-logs waste stimulate production and nutrients content of celery microgreen (Apium graveolens L.)
Authors: Elisabet  , Titisari Prima Wahyu 
Published: December 2023

Celery microgreen is celery harvested at a young stage, which is a suitable production model to support urban farming. The study aimed to investigate the potential use of eco-enzyme and oyster mushroom media waste (bag-logs waste) on the growth of celery as microgreen. The present study employed a fully randomized factorial design comprising two factors. The first factor was the dosage of eco-enzyme (E): 0.5, 15, and 25 mL L-1 of water, while the second factor was the dosage of bag-log waste (L): 0.50, 100, and 150 g/tray. The variables that were assessed included wet weight, fresh economic weight, longest root length, root volume, moisture content, vitamin C, Mg, and Ca levels. The data were subjected to ANOVA analysis and subsequently followed by the application of the HSD test at a significance level of 5%. The findings indicated that there was a substantial interaction between the eco-enzyme and bag-log waste in all observed parameters. The best treatment was the combination of eco-enzyme at a concentration of 25 mL L-1 and bag-log waste at a rate of 150 g/tray. The eco-enzyme treatment exhibited a significant impact on all observed parameters, with the most effective treatment being the application of 25 mL L-1. The bag-log waste application affected all measured parameters with 150 g/tray yielding the most favorable results. Therefore, eco-enzymes and bag-log waste have the potential as growing media for celery microgreen cultivation.
Keywords: celery, healthy food, organic farming, urban farming, zero waste
Paradoxos no acesso à saúde do idoso
Authors: Rosa Andressa Lima Sena , Luz Jenie Lana Evangelista de Sousa , Loiola Jéssica Beatriz da Silva , De Carvalho Luma Sérvulo , Leite Maria Rita do Nascimento Teixeira , Moura Michelly Bruna Soares de , Fortaleza Monique Melo , Vilanova Victor José Campelo , Nogueira Luciana Tolstenko 
Published: December 2023

Objetivo: Apresentar e analisar os fatores que corroboram o paradoxo do acesso do idoso à saúde, contrapondo os direitos previstos em lei. Revisão Bibliográfica: O aumento da expectativa de vida no Brasil despertou a necessidade da criação de leis e Estatutos específicos, a fim de garantir a saúde integral e universal aos senis. Contudo, existem entraves que impedem o acesso à saúde e, consequentemente, o bem-estar dos idosos, dentre eles a falta de recurso material e estrutural para atender essa parcela da população. Diante disso, pontua-se a infraestrutura insatisfatória das unidades de saúde, devido à falta de acessibilidade dos espaços, somado à dificuldade no deslocamento, além da escassez de insumos materiais e a burocracia exacerbada. Outrossim, existe a carência de insumos humanos, como a falta de geriatras e a ausência de um atendimento especializado e inclusivo para os idosos. Considerações finais: A partir do estudo entende-se que as leis estão sendo executadas de forma inadequada, o que prejudica o acesso do idoso à saúde. Logo, faz-se necessário a criação de políticas públicas eficientes que provoquem a mudança do cenário atual.
Prevalence of non-communicable diseases among camel milk consumers and non-consumers tribal population aged more than equal to 30 years in rural Rajasthan: A community-based cross-sectional study
Authors: Soni Vaishali , Halder Pritam 
Published: December 2023

Objectives:
There is an ongoing trend of increasing burden of non-communicable diseases among the tribal population. The objective was to determine the prevalence of non-communicable diseases among camel milk consumers (CMC) and non-consumers tribal population aged ≥ 30 years in rural Rajasthan.

Material and Methods:
A community-based cross-sectional study was conducted among 60 adults CMC aged >30 years from the Riaka tribe. Same number of non-camel milk consumers (NCMC) were recruited with respect to similar age, gender, and residence from the same tribe. After obtaining informed consent, a semi-structured interview schedule containing sociodemographic dietary characteristics was introduced to all participants in June 2013. The participants were assessed for their random blood glucose, blood pressure, and lipid profile. Data was entered into Microsoft Excel version 2013 and analyzed in Stata version 13.

Results:
Among all, 26.6% male and 23.3% female NCMC participants were found to be suffering from diabetes and in CMC male participants, only 3.3 % were found to be suffering from diabetes. The mean standard deviation (SD) random blood glucose level of CMC and NCMC participants was 98.67 ± 8.81 and 115.50 ± 28.12 mg/dL for male participants and 95.93 ± 5.17 and 110.50 ± 35.22 mg/dL for female participants, respectively, with significant statistical differences. Stage-I hypertension (HTN) was reported in only NCMC male participants, which are further classified as systolic and diastolic stage-I HTN in 4 % and 2% participants, respectively. No cases of stage II HTN were observed. Mean (SD) systolic blood pressures (mmHg) were more in NCMC (122.36 ± 7.67) than CMC (118.84 ± 5.81) female participants with a statistically significant difference (P < 0.05). In this study, we found that total cholesterol, low-density lipoprotein levels were less, and high-density lipoprotein level was more in CMC compared to NCMC irrespective of gender.

Conclusion:
The prevalence of non-communicable diseases was relatively less in CMC than NCMC irrespective of gender, suggesting the beneficial effects of camel milk consumption. It is advised that additional research be conducted in the future.
الأمير أحمد بن مروان رائد التأسيس للعمل الإنساني في الإمارة المروانية الكردية
Authors: أجقو علي 
Published: December 2023

يعتبر الامير ناصر الدولة أحمد بن مروان (401-453ه/1010-1061) من أشهر الأمراء الذين تعاقبوا على حكم الامارة المروانية. تميزت فترة حكمه بسياسة إنسانية متقدمة تمثلت في ترسيخ حق اللجوء اذ فتح باب الامارة لاستقبال الغرباء (اللاجئين) ، الترحيب بهم، توفير العيش اللائق بهم وبمكانة كل واحد منهم وفوق ذلك التعهد بعدم تسليمهم لطالبيهم بأي حال من الأحوال، حتى غدت حواضر الإمارة خاصة آمد وميفارقين ملاذا آمنا لهؤلاء الذين من بينهم الملك الأمير، الوزير، العالم ، طالب العلم والتاجر و وفر الأمان والرعاية لكل من يقصد إمارته من طلاب العلم ومن عامة الناس. وبخصوص اللاجئين، نجد الأمير يرفض طلب تسليمهم مهما كان السبب، وهو بذلك يؤسس لمبدأ عدم التسليم ئالقصري للاجئين والذي لم يتم العمل به إلا في اتفاقية عام 1951، أي بعد أكثر من 900 سنة. وهناك مسألة مهمة تحسب للأمير المرواني وهو حرصه على تعزيز سياسة حسن الجوار وعدم التدخل في الشؤون الداخلية للدول وحل الخلافات بالطرق السلمية.
Analisis Gaya Bahasa Pada Puisi "Ziarah" dan "Selamat Tidur" Karya Joko Pinurbo
Authors: Oktaviana Irma Bela , Azizah Dewi Nur , Mutammimah Nahdliyya Izzatul , Prayogi Rahmat 
Published: December 2023

Penelitian ini berisi pembahasan mengenai gaya bahasa atau majas yang terdapat dalam puisi yang berjudul “Ziarah” dan “Selamat Tidur” karya Joko Pinurbo. Tujuan dari penelitian ini untuk mengetahui jenis-jenis gaya bahasa yang terdapat pada puisi “ziarah” dan “Selamat Tidur” karya Joko Pinurbo. Dari hasil penelitian ini, pembaca diharapkan dapat mengetahui isi dari makna dalam puisi melalui diksi dan gaya bahasa yang terdapat pada puisi. Penelitian ini juga diharapkan dapat bermanfaat agar pembaca dapat dengan mudah memahami puisi dan maknanya. Analisis ini mencari gaya bahasa yang digunakan pengarang puisi agar pembaca dapat mengetahui bahasa yang digunakan oleh pengarang. Penelitian ini menggunakan metode deskriptif kualitatif dengan analisis isi yang dilakukan secara rinci. Ditemukan beberapa jenis majas seperti majas alegori, majas paralelisme, majas alusi, majas metonimia dan majas personifikasi, sarkasme, pleonasme dan majas ironi. Dari hasil pembahasan terdapat gaya Bahasa dalam puisi ziarah dan selamat tidur karya joko pinurbo terdapat dua majas personifikasi, dua majas alegori, satu majas metonimia, satu majas paralelisme, dua majas alusi,satu majas sarkasme, satu majas pleonasme, dan satu majas epitet disertai dengan frasa yang sangat menarik.Gaya Bahasa serta diksi yang terdapat dalam puisi ini sebagai pendukung khayalan atau imajinasi penulis dalam puisi tersebut. Dari hasil penelitian ini, pembaca diharapkan dapat mengetahui isi dari makna dalam puisi melalui diksi dan gaya bahasa yang terdapat pada puisi.
Kata Kunci : Gaya Bahasa, Joko Pinurbo, Puisi