bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ulinastatin ameliorates podocyte ferroptosis via regulating miR-144-3p/SLC7A11 axis in acute kidney injury
Authors: Yang Xiaosong , Guo Na 
Published: October 2023

AbstractFerroptosis is a newly discovered form of cell death characterized by intracellular iron accumulation and subsequent lipid peroxidation, which has been identified in various pathological processes, such as acute kidney injury (AKI). Ulinastatin (UTI), known as an antioxidant and anti-inflammatory, has been reported to prevent kidney injury. Here, we investigated the protective effects of UTI on LPS-induced podocyte ferroptosis in vivo and in vitro. Conditionally immortalized mouse podocyte was exposed to LPS in the presence or absence of UTI in vitro for 48 h. The levels of reactive oxygen species (ROS) and intracellular Fe2+ were detected to value the effect of UTI treatment on the podocyte cell ferroptosis. We also evaluated the influence of UTI on kidney injury in vivo. LPS-induced mice were treated with vehicle or UTI at 50 U/g/d for 6 wk. We identified the important function of UTI in repressing ferroptosis and ameliorating podocyte injury. The treatment of UTI reduced accumulation of Fe2+ and lipid ROS in podocyte. The cell proliferation was induced by UTI compared with the LPS-treated group in vitro. UTI attenuated the podocyte cytoskeletal as well. Regarding the mechanism, we found that UTI upregulated solute carrier family 7 member 11 (SLC7A11) expression by reducing miR-144-3p in the cells. The overexpression of miR-144-3p blocked the protective role of UTI in podocyte ferroptosis. MiR-144-3p/SLC7A11 axis was involved in UTI-mediated podocyte cell proliferation in vitro. Furthermore, the treatment of UTI repressed podocyte injury and proteinuria in vivo, and the level of miR-144-3p was decreased while SLC7A11 expression was increased in comparison with the model mice. UTI prevents LPS-induced podocyte ferroptosis and subsequent renal dysfunction through miR-144-3p/SLC7A11 axis. These findings might provide a potential novel therapeutic option for AKI and other renal diseases affecting podocyte.
Über 15 Jahre „Kein Täter werden“ – mehr Schaden als Nutzen?
Authors: König Andrej 
Published: October 2023

ZusammenfassungDer verursacherbezogene Dunkelfeldansatz des Präventionsnetzwerkes „Kein Täter werden“ bietet seit über einem Jahrzehnt nichtstrafverfolgten pädophilen und/oder hebephilen Hilfesuchenden therapeutische Unterstützung zur Verhinderung von sexualisierter Gewalt gegen Minderjährige an. Kritiker bemängeln jedoch methodische Schwächen in den durchgeführten Selbstevaluationsstudien der Projektverantwortlichen, die die kriminalpräventive Wirksamkeit infrage stellen. Die selbstberichtete Kriminalitätsbelastung liegt in einer aktuellen Follow-up-Untersuchung im Vergleich zu kriminologischen Hellfeldstudien mit Sexualstraftätern deutlich höher. Aus forensisch-kriminologischer Sicht lässt der in Berlin etablierte verursacherbezogene Dunkelfeldansatz erhebliche Zweifel an seiner kriminalpräventiven Wirksamkeit aufkommen.
Exploiting Electronic Data to Advance Knowledge and Management of Severe Infections
Authors: Laupland Kevin B. , Tabah Alexis , White Kyle C. , Ramanan Mahesh 
Published: October 2023

Abstract
Purpose of Review
To identify opportunities and recent advances in the use of multicentric digital data sources and networks to investigate the epidemiology and management of patients with infections admitted to intensive care units (ICUs).

Recent Findings
Electronic surveillance systems for a range of serious infections have been reported from large cohorts with evident improvements in efficiency, objectivity, and comprehensiveness of coverage as compared to traditional methods. Electronic data, most notably from electronic health records, has been used to define the epidemiology and outcomes of severe infections in several settings and conditions and has facilitated population-based evaluation. Automated alerts and notifications hold promise to identify patients at risk for sepsis and bloodstream infection although demonstration of efficacy in interventional trials is needed.

Summary
Exploitation of electronic data in ICUs has led to a better understanding of the epidemiology of severe infections and holds promise for future interventional clinical trials.
“Land-sparing benefits biodiversity while land-sharing benefits ecosystem services”: Stakeholders’ perspectives on biodiversity conservation strategies in boreal forests
Authors: Löfroth Therese , Merinero Sonia , Johansson Johanna , Nordström Eva-Maria , Sahlström Emma , Sjögren Jörgen , Ranius Thomas 
Published: October 2023

AbstractBiodiversity conservation and economic profit from forests can be combined by various land-sparing and land-sharing approaches. Using a semi-structured survey, we evaluated support for scenarios representing contrasting conservation strategies in a managed boreal forest landscape. Land-sparing approaches were supported by the conservation organisation, regional administrations and the forest company, mainly motivated by the benefit for biodiversity based on ecological theory. Land-sharing approaches were supported by one recreational organisation, some municipalities and the forest owners’ association, mainly motivated by the delivery of ecosystem services. Stakeholder groups using certain ecosystem services had motivations that we related to an anthropocentric mindset, while others focused more on species conservation, which can be related both to an anthropocentric or an ecocentric mindsets. Forest conservation planning should consider stakeholders’ preferences to handle land-use conflicts. Since reaching consensus among multiple stakeholders seems unfeasible, a combination of land-sparing and land-sharing approaches is probably the best compromise.
Optimizing the number of crews working in parallel and their work sequence to minimize project duration and cost for repetitive construction projects
Authors: Abdelbasset Emad , Hassan Abbas , Amer Nabil H. , Khalifa Yasser A. 
Published: October 2023

AbstractScheduling repetitive construction projects poses a significant challenge in optimally utilizing multiple concurrent crews and sequencing their work to minimize project duration and cost. To address this challenge, this study presents the development of a multi-objective scheduling optimization model for repetitive construction projects consisting of three modules. First, a scheduling module ensures the harmonious coordination of multiple concurrent crews for each activity while considering varying productivity rates, work continuity constraints, and project precedence relationships. Second, a cost module incorporates various contractual cost components to enable a thorough evaluation of project costs and provides flexibility to contractors encountering different contract terms. Third, an optimization module utilizes a genetic algorithm to identify optimal combinations of crews working in parallel and their optimal work sequence, to simultaneously minimize project duration and cost. An application example from the literature was analyzed to validate the model and demonstrate its superiority over previous models. The results showed significant reductions of 8% and 0.78% in project duration and overall costs, respectively, compared to previous models. Furthermore, the capabilities of the model were demonstrated through a real-life case study involving a highway development and renovation project, highlighting its practical benefits and effectiveness in a real-world construction scenario.
Change point detection in text data
Authors: Preis Axel , Schwaar Stefanie 
Published: October 2023

AbstractThe analysis of text data using artificial intelligence and statistical methods has become increasingly important in recent years. One application is the automatic assignment of documents. For this purpose, a classification model is trained on the basis of historical data. If the structure of the texts to be classified changes over time, the quality of the classification will decrease. Change point detection algorithms can counteract this. Such algorithms automatically detect changes in the structure of the texts and indicate that the trained classification model has to be adapted. However, the undesired influence of the length of the document needs to be handled when modeling the text data. We present a multinomial change-point model detecting changes in text structures. The results are supported by simulation studies.
GIS-assisted Flood-risk Potential Mapping of Ilorin and its Environs, Kwara State, Nigeria
Authors: Alimi S. A. , Oriola E. O. , Senbore S. S. , Alepa V. C. , Ologbonyo F. J. , Idris F. S. , Ibrahim H. O. , Olawale L. O. , Akinlabi O. J. , Ogungbade O. 
Published: October 2023

AbstractThe incessant reoccurrence of flooding disasters across Nigeria has mandated an urgent outlook on flood-risk management techniques. Ilorin and its environs have suffered immensely from annual flood reoccurrence. This study aims to assess flood risk within Ilorin and its environs and proffer adequate flood mitigation strategies that governments and policymakers can adopt to placate future flooding events within the state. Satellite imagery data were acquired and analyzed for flood-risk assessment of the area. Ten highly influential flood causative factors were synergized using Multi-Criteria Decision-Making techniques in this research; they are Land Surface Temperature, Elevation, Soil Moisture Index, and Distance to Stream, Drainage Density, Stream Power Index, Normalized Difference Vegetation Index, Land Use Land Cover, Slope, and Topographic Wetness Index. Findings showed that approximately 47.2% of the study area had low flood risk, while moderate and high flood-risk zones occupied 33.5% and 19.29%, respectively. Most parts of Ilorin and its environs are safe from flood disasters; only about one-quarter of the total area under investigation lies in the high flood-risk zones; these areas mostly fall within the shores of major streams, rivers, and dams within the state. A plot of previous flood cases in the state placed the affected areas in the high and moderate zones of flood risk, confirming the efficacy of geospatial techniques in flood-risk assessment. It is hoped that this study's findings and recommendations can be implemented to prevent future devastating flooding occurrences within the state.
Molecular layer deposition of hybrid silphenylene-based dielectric film
Authors: Li Xinzhi , Vehkamäki Marko , Chundak Mykhailo , Mizohata Kenichiro , Vihervaara Anton , Putkonen Matti , Leskelä Markku , Ritala Mikko 
Published: October 2023

AbstractMolecular layer deposition (MLD) offers molecular level control in deposition of organic and hybrid thin films. This article describes a new type of inorganic–organic silicon-based MLD process where Aluminium chloride (AlCl3) and 1,4-bis(triethoxysilyl)benzene (BTEB) were used as precursors. Hybrid films were deposited at a temperature range of 300 to 500 °C and high growth per cycle (GPC) up to 1.94 Å was obtained. Field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) were used to analyze the appearance of the film surface. The hybrid film was amorphous in low-magnification FESEM images but some particulates appeared in high-magnification FESEM images (200 k). Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), Time-of-flight elastic recoil detection analysis (ToF-ERDA), and X-ray photoelectron spectroscopy (XPS) were employed to analyze the structure and composition of the hybrid film. The ratio of Al/Si in the hybrid film was 0.8. The storage environment of the films affected their capacitance, dielectric constant, leakage performance, and breakdown voltage. A film stored in a high vacuum (10–6 mbar) environment had low leakage current density (< 10–6 A × cm−2 at an applied voltage of 28 V) and a dielectric constant of 4.94, which was much smaller than after storing in a humid ambient environment.
Graphical abstract
Influence of pH on the Hydrothermal Synthesis of Al-Substituted Smectites (Saponite, Beidellite, and Nontronite)
Authors: Criouet I. , Viennet J. C. , Baron F. , Balan E. , Buch A. , Delbes L. , Guillaumet M. , Remusat L. , Bernard S. 
Published: October 2023

AbstractSmectitic clay minerals are unique indicators of paleoenvironmental conditions and exhibit a unique reactivity in the mineral world. Smectites may exhibit tetrahedral substitutions (Al3+, and sometimes Fe3+, can substitute for Si4+ in tetrahedral sites), resulting in a layer-charge increase, thereby impacting their properties (e.g. swelling and sorption capacities, catalytic properties, expandable abilities). The objective of the present study was to determine the influence of pH conditions on the hydrothermal production of smectite end-members exhibiting tetrahedral Al substitutions (saponite, beidellite, and nontronite), using X-ray diffraction (XRD) and Fourier-transform infrared (FTIR) methods. The results of a series of syntheses conducted at various pH values allowed discussion of the crystallization pathways of these smectites from a mechanistic point of view. Altogether, the present study provided easily reproducible protocols for the hydrothermal production of pure saponite, nontronite, or beidellite (i.e. with no other mineral). The successful synthesis of pure saponite was achieved by exposing the starting gels to 230°C for 4 days in solutions at pH ranging from 5.5 to 14. The successful synthesis of pure beidellite was achieved by exposing the starting gels to 230°C for 9 days in a solution at pH 12. The successful synthesis of pure nontronite was achieved by exposing the starting gels to 150°C for 2.5 days in a solution at pH 12.5. Although extrapolating experimental results to natural settings remains difficult, the results of the present study may be of great help to constrain better the geochemical conditions existing or having existed on extraterrestrial planetary bodies.
The Characteristics of the Yangtze Flooding During 1998 and 2020 Based on Atmospheric Water Tracing
Authors: Pan Chen , Zhao Jiuwei , Chen Hao , Kang Zhiming , Chen Shengjie , Jin Xiaoxia 
Published: October 2023

AbstractThe June‐July Yangtze flooding in 1998 and 2020 drew incredible attention owing to the extreme precipitation events and devastating societal/economic damages. However, the quantitative estimation of the moisture transport mechanism is intensely discussed but still unresolved. Here we investigated two events from a unique perspective of Eulerian atmospheric water tracers that tries to explain the two events from model physics. The results showed that the moisture supplies from the Northwest Pacific decreased despite of different inducements, whereas the southwest summer monsoon (SWSM)‐related moisture supplies exhibited conspicuous enhancements in both events, suggesting that the SWSM‐related moisture supplies controlled the occurrence of Yangtze flooding. The physical processes of the two events were further compared. The 2020 flooding was more severe than the 1998 event, which was related to the stronger advective convergences and in‐stratus condensations of the SWSM‐related moisture.
Exciton fine structure in twisted transition metal dichalcogenide heterostructures
Authors: Kundu Sudipta , Amit Tomer , Krishnamurthy H. R. , Jain Manish , Refaely-Abramson Sivan 
Published: October 2023

AbstractMoiré superlattices of transition metal dichalcogenide (TMD) heterostructures give rise to rich excitonic phenomena associated with the interlayer twist angle. Theoretical calculations of excitons in such systems are typically based on model moiré potentials that mitigate the computational cost. However, predictive understanding of the electron-hole coupling dominating the excitations is crucial to realize the twist-induced modifications of the optical selection rules. In this work, we use many-body perturbation theory to evaluate the relation between twist angle and exciton properties in TMD heterostructures. We present an approach for unfolding excitonic states from the moiré Brillouin zone onto the separate-layer ones. Applying this method to a large-angle twisted MoS2/MoSe2 bilayer, we find that the optical spectrum is dominated by mixed electron–hole transitions with different momenta in the separate monolayers, leading to unexpected hybridization between interlayer and intralayer excitons. Our findings offer a design pathway for exciton layer-localization in TMD heterostructures.
The burden of splice-disrupting variants in inherited heart disease and unexplained sudden cardiac death
Authors: Singer Emma S. , Crowe Joshua , Holliday Mira , Isbister Julia C. , Lal Sean , Nowak Natalie , Yeates Laura , Burns Charlotte , Rajagopalan Sulekha , Macciocca Ivan , King Ingrid , Wacker Julie , Ingles Jodie , Weintraub Robert G. , Semsarian Christopher , Bagnall Richard D. 
Published: October 2023

AbstractThere is an incomplete understanding of the burden of splice-disrupting variants in definitively associated inherited heart disease genes and whether these genes can amplify from blood RNA to support functional confirmation of splicing outcomes. We performed burden testing of rare splice-disrupting variants in people with inherited heart disease and sudden unexplained death compared to 125,748 population controls. ClinGen definitively disease-associated inherited heart disease genes were amplified using RNA extracted from fresh blood, derived cardiomyocytes, and myectomy tissue. Variants were functionally assessed and classified for pathogenicity. We found 88 in silico-predicted splice-disrupting variants in 128 out of 1242 (10.3%) unrelated participants. There was an excess burden of splice-disrupting variants in PKP2 (5.9%), FLNC (2.7%), TTN (2.8%), MYBPC3 (8.2%) and MYH7 (1.3%), in distinct cardiomyopathy subtypes, and KCNQ1 (3.6%) in long QT syndrome. Blood RNA supported the amplification of 21 out of 31 definitive disease-associated inherited heart disease genes. Our functional studies confirmed altered splicing in six variants. Eleven variants of uncertain significance were reclassified as likely pathogenic based on functional studies and six were used for cascade genetic testing in 12 family members. Our study highlights that splice-disrupting variants are a significant cause of inherited heart disease, and that analysis of blood RNA confirms splicing outcomes and supports variant pathogenicity classification.
A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response
Authors: Mazboudi Ryan , Mulhall Maasz Hannah , Resch Matthew D. , Wen Ke , Gottlieb Paul , Alimova Aleksandra , Khayat Reza , Collins Natalie D. , Kuschner Robert A. , Galarza Jose M. 
Published: October 2023

AbstractAdenoviruses (AdVs) cause infections in humans that range from mild to severe, and can cause outbreaks particularly in close contact settings. Several human AdV types have been identified, which can cause a wide array of clinical manifestations. AdV types 4 and 7 (AdV-4 and AdV-7), which are among the most commonly circulating types in the United States, are known to cause acute respiratory disease that can result in hospitalization and rarely, death. Currently, the only vaccines approved for use in humans are live virus vaccines against AdV-4 and AdV-7, though these vaccines are only authorized for use in U.S. military personnel. While they are efficacious, use of these live virus vaccines carries considerable risks of vaccine-associated viral shedding and recombination. Here, we present an alternative vaccination strategy against AdV-7 using the virus-like particle platform (AdVLP-7). We describe the production of stable recombinant AdVLP-7, and demonstrate that AdVLP-7 is structurally analogous to wild-type AdV-7 virions (WT AdV-7). Preclinical immunogenicity studies in mice show that AdVLP-7 elicits a potent humoral immune response, comparable to that observed in mice immunized with WT AdV-7. Specifically, AdVLP-7 induces high titers of antibodies against AdV-7-specific antigens that can effectively neutralize AdV-7.
Erasure conversion in a high-fidelity Rydberg quantum simulator
Authors: Scholl Pascal , Shaw Adam L. , Tsai Richard Bing-Shiun , Finkelstein Ran , Choi Joonhee , Endres Manuel 
Published: October 2023

AbstractMinimizing and understanding errors is critical for quantum science, both in noisy intermediate scale quantum (NISQ) devices1and for the quest towards fault-tolerant quantum computation2,3. Rydberg arrays have emerged as a prominent platform in this context4with impressive system sizes5,6and proposals suggesting how error-correction thresholds could be significantly improved by detecting leakage errors with single-atom resolution7,8, a form of erasure error conversion9–12. However, two-qubit entanglement fidelities in Rydberg atom arrays13,14have lagged behind competitors15,16and this type of erasure conversion is yet to be realized for matter-based qubits in general. Here we demonstrate both erasure conversion and high-fidelity Bell state generation using a Rydberg quantum simulator5,6,17,18. When excising data with erasure errors observed via fast imaging of alkaline-earth atoms19–22, we achieve a Bell state fidelity of$$\ge 0.997{1}_{-13}^{+10}$$≥0.9971−13+10, which improves to$$\ge 0.998{5}_{-12}^{+7}$$≥0.9985−12+7when correcting for remaining state-preparation errors. We further apply erasure conversion in a quantum simulation experiment for quasi-adiabatic preparation of long-range order across a quantum phase transition, and reveal the otherwise hidden impact of these errors on the simulation outcome. Our work demonstrates the capability for Rydberg-based entanglement to reach fidelities in the 0.999 regime, with higher fidelities a question of technical improvements, and shows how erasure conversion can be utilized in NISQ devices. These techniques could be translated directly to quantum-error-correction codes with the addition of long-lived qubits7,22–24.
Flexible circuit mechanisms for context-dependent song sequencing
Authors: Roemschied Frederic A. , Pacheco Diego A. , Aragon Max J. , Ireland Elise C. , Li Xinping , Thieringer Kyle , Pang Rich , Murthy Mala 
Published: October 2023

AbstractSequenced behaviours, including locomotion, reaching and vocalization, are patterned differently in different contexts, enabling animals to adjust to their environments. How contextual information shapes neural activity to flexibly alter the patterning of actions is not fully understood. Previous work has indicated that this could be achieved via parallel motor circuits, with differing sensitivities to context1,2. Here we demonstrate that a single pathway operates in two regimes dependent on recent sensory history. We leverage the Drosophila song production system3 to investigate the role of several neuron types4–7 in song patterning near versus far from the female fly. Male flies sing ‘simple’ trains of only one mode far from the female fly but complex song sequences comprising alternations between modes when near her. We find that ventral nerve cord (VNC) circuits are shaped by mutual inhibition and rebound excitability8 between nodes driving the two song modes. Brief sensory input to a direct brain-to-VNC excitatory pathway drives simple song far from the female, whereas prolonged input enables complex song production via simultaneous recruitment of functional disinhibition of VNC circuitry. Thus, female proximity unlocks motor circuit dynamics in the correct context. We construct a compact circuit model to demonstrate that the identified mechanisms suffice to replicate natural song dynamics. These results highlight how canonical circuit motifs8,9 can be combined to enable circuit flexibility required for dynamic communication.