bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical Predictors of Access‐Related Vascular Complications Following Transfemoral Transcatheter Aortic Valve Replacement
Authors: Demirci Gökhan , Aslan Serkan , Şahin Ahmet Anıl , Demir Ali R. , Erata Yunus Emre , Türkmen İrem , Kanyılmaz Mehmet , Türkvatan Aysel , Ertürk Mehmet 
Published: January 2025

ABSTRACTBackgroundAccess‐related vascular complications (VCs) after percutaneous transfemoral transcatheter aortic valve replacement (TAVR) are associated with poor clinical outcomes and remain a significant challenge despite technological advances. The aim of this study was to identify anatomic predictors of access‐related VCs after TAVR on preprocedural contrast‐enhanced multidetector computed tomography (MDCT).AimsThe aim of this study was to identify anatomical predictors of access‐related VCs after TAVR on preprocedural contrast‐enhanced MDCT.MethodsA total of 348 consecutive patients with symptomatic severe AS who underwent transfemoral TAVR were included retrospectively. The primary endpoint of the study was the composite of minor and major access site complications as defined by the Valve Academic Research Consortium‐3 (VARC‐3) criteria. The study population was divided into two groups according to the VC including VC (+) and VC (−).ResultsA total of 101 patients (29%) developed VC (8.7% major, 20.3% minor) following TAVR. Regression analysis identified severe CFA calcification (p = 0.004), CFA depth (p < 0.001), minimum CFA diameter (p < 0.001), CFA depth‐to‐diameter ratio ≥ 5.6 (p < 0.001), and sheath‐to‐femoral artery ratio (SFAR) (p < 0.001) as significant predictors of VC. ROC curves generated for the occurrence of VC, the AUC for the femoral artery depth‐to‐diameter ratio (0.720) was higher than the AUC for the SFAR and the depth of the femoral artery (0.636, 0.630).ConclusionComplications related to vascular access sites continue to be a significant concern for patients undergoing TF‐TAVR. The CFA depth‐to‐diameter ratio has demonstrated superior predictive performance for VC compared to SFAR as expressed in the literature. Utilizing this criterion may enhance risk stratification for VC in high‐risk patients, potentially reducing associated morbidity and mortality.
Phase Behavior Determines Morphology of Amylose Crystallized From Aqueous Solutions
Authors: Ziegler Gregory R. , Creek John A. 
Published: January 2025

ABSTRACTBackground and ObjectivesHere, we present a simplified system comprising amylose of varying degrees of polymerization in water, with the goal of probing the temperature–concentration phase diagram to determine if a miscibility gap leading to liquid−liquid phase separation might serve as a model for starch granule initiation and, if so, under what conditions.FindingsA miscibility gap in the cooling‐rate‐dependent phase behavior is demonstrated for the amylose−water system, with its temperature and concentration depending on the degree of polymerization (DP) of the starch. Liquid–liquid phase separation within this miscibility gap followed by crystallization of the polymer‐rich phase produced spherulites. If crystallization preceded liquid–liquid phase separation, a precipitate or gel was formed. The upper critical solution temperature appeared between 60°C and 70°C, and the miscibility gap was observed between 5% and 30%–50% w/w starch, depending on DP for DP ≥ 68. For DP 29, the miscibility gap occurred at concentrations ≥ 20% w/w.ConclusionsA cooling‐rate‐dependent miscibility gap in the temperature–concentration phase diagram has been observed in aqueous amylose solutions under reasonable ambient conditions of temperature and starch concentration, allowing phase separation to occur within plastids in vivo.Significance and NoveltyThis work provides a biophysical complement to the biochemistry associated with starch granule initiation.
Predicting Hand Folded Japanese Sponge Cake Quality Using Rapid Visco Analyzer Flour Pasting Properties
Authors: Mense Andrew L. , Ross Andrew S. , Bock Jayne E. 
Published: January 2025

ABSTRACTBackground and ObjectivesThe objective of this study was to evaluate a series of Rapid Visco Analyzer (RVA) methods for their ability to produce results that were predictive of hand folded Japanese sponge cake (JSC) quality. Two solvents (water and 50% [w/w] aqueous sucrose) and two temperature profiles (Standard 1 [STD 1] and an internal cake temperature profile) were selected to run across a set of flour samples from two crop years. The RVA results were previously analyzed (and published) for their ability to produce results that were predictive of mechanically folded JSC. Due to the continued use of the hand fold method, there was a need to understand how these RVA methods produced results that were predictive of hand folded JSC quality. Hand folded JSC is prepared by manually folding the flour into the egg sugar mixture using a wooden paddle, while the mechanical folding method utilizes a KitchenAid with attached paddle.FindingsWater, 5% lactic acid, 5% sodium carbonate, and 50% sucrose SRC solvents showed no significant correlations with JSC quality. RVA viscosity results from both profiles using water were generally not significantly correlated with JSC quality while the sucrose solvent batter pasting viscosity (BPV) was significantly correlated. RVA BPV run with the internal cake temperature profile using the sucrose solvent showed significant correlations with hand folded JSC volume (r = 0.76, p ≤ 0.05), firmness (r = −0.89, p ≤ 0.01), and overall score (r = 0.79, p ≤ 0.01).ConclusionsThe RVA BPV results showed that a 50% (w/w) sucrose solvent, when compared to water, could more accurately be used to predict and screen for JSC quality outcomes. The internal cake temperature profile BPV was better correlated with hand folded JSC quality than the STD 1 profile when using sucrose solvent.Significance and NoveltyThis research identified that the RVA BPV employing the internal cake temperature profile, and a 50% sucrose solvent could estimate hand folded JSC quality using less flour and taking less time than a bake test.
Intravascular Large B‐Cell Lymphoma Mimicking Intrahepatic Cholangiocarcinoma
Authors: Oshima Seigi , Sakamoto Soichiro , Takahashi Ken , Kitano Toshiyuki 
Published: January 2025

ABSTRACTIntravascular large B‐cell lymphoma (IVLBL) poses a diagnostic challenge due to its varied, nonspecific symptoms. Utilizing PET‐CT can be valuable in identifying lesions across the body, aiding clinicians in targeted biopsy planning. Clinicians need to be aware that IVLBL may manifest hepatic lesions along Glisson's sheath mimicking intrahepatic cholangiocarcinoma.
Pulmonary Embolism: Highlighting Iron Deficiency Anemia as a Contributing Factor in the Development of Pulmonary Embolism—A Case Report
Authors: Yogeeta Fnu , Devi Muskan , Rauf Sameer Abdul , Tooba Fnu , Sumar Khadija Asif , Haque Md Ariful 
Published: January 2025

ABSTRACTThis case emphasizes iron deficiency anemia (IDA) as a potential risk factor for pulmonary embolism (PE), especially in patients with type 2 diabetes. Early recognition and management of PE and IDA are crucial. Further research is needed to clarify the mechanisms linking IDA to thrombosis and improve prevention strategies.
Recent advances in non‐noble metal‐based electrocatalysts for hybrid water electrolysis systems
Authors: Zhang Xiaoyu , Wang Jiayi , Zong Kai , Chen Zhen , Yang Xin , Yang Lin , Wang Xin , Chen Zhongwei 
Published: January 2025

AbstractThe electrocatalytic water‐splitting process is widely acknowledged as the most sustainable and environmentally friendly technology for hydrogen (H2) production. However, its energy efficiency is significantly constrained by the kinetically slow oxygen evolution reaction (OER) at the anode, which accounts for about 90% of the electrical energy consumption in the water‐splitting process. A new strategy is urgently needed to reduce its energy consumption. In recent years, electrochemical oxidation of small molecules has been considered for replacement of OER for efficient H2 production, due to its benign operational conditions, low theoretical thermodynamic potential, high conversion efficiency and selectivity, and environmental sustainability. Hybrid electrolysis systems, by integrating cathodic hydrogen evolution reaction with anodic oxidation of small molecules, have been introduced, which can generate high‐purity H2 and produce value‐added products or pollutant degradation. In this review, we highlight the recent advancements and significant milestones achieved in hybrid water electrolysis systems. The focus is on non‐noble metal electrocatalysts, reaction mechanisms, and the construction of electrolyzers. Additionally, we present the prevailing challenges and future perspectives pertinent to the evolution of this burgeoning technology.
Digital twins: Transforming the chemical process industry—A review
Authors: Pal Pratyush Kumar , Hens Abhiram , Behera Narottam , Lahiri Sandip Kumar 
Published: January 2025

AbstractDigital twin (DT) technology represents a significant advancement in the digital transformation of the chemical process industry (CPI), offering innovative capabilities for real‐time monitoring, predictive maintenance, and process optimization. This review investigates the current deployment status, frameworks, architectures, and applications of DTs within CPI, highlighting their transformative potential in improving operational efficiency, enhancing safety, and promoting sustainability. By examining case studies from industry leaders and analyzing recent advancements, this study elucidates the critical roles of DTs in asset health monitoring, process optimization, and environmental performance. The review identifies key components of DT frameworks, including data integration, hybrid modelling, and real‐time analytics, which are essential for effective implementation. It further explores challenges such as high computational requirements, integration with legacy systems, cybersecurity risks, and the lack of standardization, which impede widespread adoption. Despite these challenges, the paper emphasizes opportunities for leveraging advanced technologies such as artificial intelligence, edge computing, and 5G connectivity to enhance DT capabilities and scalability. In addition, this review underscores the importance of DTs in addressing global sustainability goals, mainly through their ability to optimize energy consumption, reduce emissions, and facilitate circular economy practices. By synthesizing insights from academia and industry, this study provides a comprehensive understanding of DTs' current state and future potential in CPI, offering strategic directions for research and development. The findings contribute to advancing the deployment of DTs as a cornerstone technology in achieving operational excellence, safety, and sustainability in the chemical process industry.
Simulation of a bubbling fluidized bed reactor for phosphogypsum decomposition with carbon monoxide
Authors: Laasri Fadoua , Mostoufi Navid , Garcia Adrian Carrillo , Chaouki Jamal 
Published: January 2025

AbstractPhosphogypsum (PG), a by‐product of the phosphoric acid industry and rich in calcium sulphate (CaSO4), has an unfavourable environmental impact, making its management one of the crucial issues of phosphoric acid production. As a result, PG production is integrated with or without treatment in many industries, such as agriculture, building materials, and sulphuric acid. In the latter application, carbon monoxide (CO) is used to decompose PG to extract the sulphur according to a two‐parallel reaction producing calcium sulphide (CaS) and calcium monoxide (CaO) in the solid phase. To depict the effect of the solid temperature (T), CO partial pressure (PCO), inlet gas velocity (U0), residence time (), particle size (PS), and solid exchange coefficient () on the overall fluidized bed reactor performance, a simulation study was performed according to the dynamic two‐phase model. The results show that CO partial pressure, solid residence time, particle size, and inlet gas velocity have the most significant effect on the PG conversion. On the other hand, the temperature and partial pressure of CO have the most critical effect on product selectivity. The concentration profiles of both reactants CaSO4 and CO reveal that the reaction in the emulsion phase is faster than in the bubble phase due to the good mixing in this phase.
Effect of High‐Fat Diets on the Pharmacokinetics of Bedaquiline Fumarate Tablet: A Trial in Healthy Chinese Participants
Authors: Wang Xuanxuan , Zhao Xiaoyu , Yang Shaomei , He Kun , Wen Qing , Zhang Wenyu 
Published: January 2025

AbstractBedaquiline is employed to treat multidrug‐resistant and extensive drug‐resistant tuberculosis by inhibiting the proton pump of adenosine triphosphate synthase in Mycobacterium tuberculosis. This study aims to investigate the effect of high‐fat diets on the pharmacokinetics of bedaquiline through a single‐center, open‐label, randomized trial in healthy Chinese participants. Bedaquiline fumarate tablets were administered at a dosage of 100 mg under both fasted conditions and high‐fat diet conditions. The concentrations were determined using liquid chromatography‐tandem mass spectrometry, and the pharmacokinetic parameters were calculated using a noncompartmental model. The high‐fat diet group showed a maximum plasma concentration that exceeded that of the fasted group by more than 4‐fold and an area under the concentration‐time curve from time 0 to the last measurable point that was more than twice as high. Moreover, compared to the fasted group, the high‐fat diet group exhibits significantly lower levels of apparent clearance, indicating that the high‐fat diet markedly enhances the rate and extent of gastrointestinal absorption of bedaquiline. To optimize drug bioavailability and absorption and ensure safety, the administration of bedaquiline with food is recommended in accordance with clinical usage guidelines and expert consensus.
The High Place Phenomenon: Associations With Markers of Positive and Negative Mental Health in Individuals Suffering From Specific Phobia or Agoraphobia
Authors: Wiesmann Lara , Wannemüller André , Teismann Tobias 
Published: January 2025

ABSTRACTBackgroundThe Call of the Void phenomenon describes an inexplicable urge to consider dangerous or self‐destructive actions in certain situations. Previous studies have focused on the high place phenomenon (HPP), which is the sudden urge to jump from high places. One aim of this study is to replicate the previously found associations of HPP with suicidality and anxiety in a larger sample of patients suffering from flight phobia or agoraphobia. Furthermore, the influence of personality traits and protective factors, such as self‐efficacy and self‐esteem, will be examined to identify associations between the HPP and potential markers of both positive and negative mental health.MethodsThe study sample comprised 612 patients (76% female; Mage = 43.77, SDage = 12.82) suffering from clinically relevant fear of flying. Participants filled out questionnaires on experiences with the high place phenomenon, depression, personality traits, anxiety sensitivity, suicidal ideation, insecurity in social contact, flight phobia symptoms, positive mental health, self‐efficacy expectations, self‐esteem and satisfaction with life.ResultsConsistent with previous findings, the high place phenomenon was known to nearly 43% of the patient sample. Multiple regression analysis showed that openness to experiences, neuroticism, suicidal ideation and insecurity in social contacts were positively related to the high place phenomenon, whereas agreeableness, self‐efficacy and self‐esteem were negatively related.ConclusionThe high place phenomenon is a common experience in individuals, whether or not they suffer from suicidal ideation. It is therefore cautioned not to interpret such experiences as an expression of a hidden death wish. Nevertheless, the occurrence of the HPP is influenced by the presence of negative and positive mental health markers. Future studies should examine the association between HPP and intrusions in the context of obsessive‐compulsive disorders.
Localized Janus Kinase Inhibition Modulation as Standalone or Synergistic Therapy With Narrowband UVB Photo Stimulation in Vitiligo Management: A Systematic Review and Meta‐Analysis
Authors: Kumar Vaibhav , Kapoor Rinky , Gulhane Avani , Shome Debraj , Pai Khot Atrey J. , Mhatre Pranjal , Bellani Depti 
Published: January 2025

ABSTRACTBackgroundVitiligo is a chronic autoimmune dermatosis characterized by progressive hypopigmentation, which affects ~0.2%–2% of the global population. This condition can have significant psychosocial impacts, particularly in individuals with darker skin phenotypes. Recent studies have suggested that Janus kinase (JAK) inhibitors, especially topical ruxolitinib, could offer therapeutic potential in managing vitiligo.ObjectiveTo systematically review the therapeutic efficacy, safety profile, and potential synergistic effects of topical JAK inhibitors, particularly ruxolitinib, in the treatment of vitiligo.MethodsA systematic review was conducted in accordance with the PRISMA guidelines. Data from 6 studies, encompassing 385 subjects, were synthesized. The primary outcome measure was the improvement in Vitiligo Area Scoring Index (VASI), and the methodological quality was assessed using the MINORS scale.ResultsTopical ruxolitinib demonstrated a statistically significant improvement in VASI scores (pooled estimate = 0.58; 95% CI: 0.44–0.73; p ≤ 0.001). The synergistic effect of ruxolitinib combined with narrowband ultraviolet B (NB‐UVB) phototherapy yielded a mean VASI score improvement of 37.6%. Furthermore, 30.4% of patients receiving 1.5% ruxolitinib cream achieved a 75% improvement in facial VASI (F‐VASI) scores.ConclusionTopical JAK inhibitors, including ruxolitinib, show considerable efficacy in improving VASI scores and facilitating repigmentation in vitiligo patients. The combination of JAK inhibitors with NB‐UVB therapy demonstrates enhanced therapeutic effects. These findings underscore the potential of JAK inhibitors as effective treatment modalities, although further research is needed to standardize treatment protocols and evaluate long‐term impacts on patient quality of life.
Time‐series ground surface deformation revealed by advanced land observing satellite‐2 and Sentinel‐1 along the Bei'an‐Hei'he highway in Northeast China
Authors: Yan Aoxiang , Guo Ying , Shan Wei , Zeng Xujing , Qiu Lisha , Zhang Chengcheng , Liu Shuai , Shan Monan , Ji Qingzhao 
Published: January 2025

AbstractClimate warming, human activities and the subsequent warming and thawing of permafrost have led to ground surface instability, threatening infrastructures and indigenous northern communities. The northern Da and Xiao Xing'anling mountain ranges, home to the largest latitudinal permafrost region in China, highlight the importance of monitoring the thermal state of permafrost for understanding climate change and regional economic development. This study utilized 11 scenes of the Advanced Land Observing Satellite‐2 (ALOS‐2) data and 54 scenes of Sentinel‐1 data from March 2018 to December 2019 to evaluate the ground surface deformation of the Bei'an‐Hei'he Highway (BHH) in Northeast China. ALOS‐2 results showed deformation rates ranging from −30 to +35 mm/year, while Sentinel‐1, from −30 to +30 mm/year (negative values indicate subsidence and positive, frost heaving). The subsidence zone (deformation rate exceeding −15 mm/year) was found in areas with significant variations in permafrost temperature (greater than ±0.8°C), and deformation rates correlated positively to daily precipitation and air temperature. Thaw settlement was predominantly observed in areas at low elevations (140 to 425 m) and on gentle slope angles (2–6°), affecting both south‐ and north‐facing slopes. A comparison of data sources revealed that ALOS‐2 data were more sensitive to areas with high normalized difference vegetation index (NDVI) values, while Sentinel‐1 provided more detailed deformation data in regions with low NDVI. This study contributes valuable data and ongoing assessments for road surface stability in permafrost regions of Northeast China.
Mannitol Induces Mercury Tolerance in Lettuce (Lactuca sativa) Through Improved Growth, Photosynthetic Efficiency, and Antioxidant Activity
Authors: Abdulveli Busra Arikan 
Published: January 2025

ABSTRACTMercury (Hg) is a hazardous heavy metal that disrupts plant growth and metabolism, posing significant risks to agriculture and human health. The widespread use of Hg in industrial activities and agricultural chemicals has exacerbated Hg contamination in soil and water, resulting in severe phytotoxic effects on crops, including lettuce (Lactuca sativa L.). This study explores the potential of mannitol, an osmolyte known for its protective properties, to mitigate Hg‐induced stress in lettuce. Lettuce plants were exposed to Hg stress (10 mg L−1) and treated with foliar applications of mannitol (15 mM) to assess its impact on growth, photosynthetic performance, and oxidative stress responses. Under Hg stress, lettuce exhibited a significant reduction in relative growth rate (RGR) by 31% and relative water content (RWC) by 20%. However, mannitol treatment enhanced RGR by 18% and improved RWC by 13% in Hg‐stressed plants. Nutrient analysis revealed that mannitol treatment restored K, Fe, Mn, and Zn levels, which were otherwise depleted by Hg exposure. Photosynthetic parameters were adversely affected by Hg, with a 62% reduction in carbon assimilation rate (A). Mannitol treatment partially recovered A by 55% and improved PSII photochemistry, including Fv/Fm and Fv/Fo. Mannitol also moderated oxidative stress indicators, evidenced by decreased H2O2 and lipid peroxidation levels, and enhanced the activities of key antioxidant enzymes such as superoxide dismutase (SOD), peroxidase (POX), and catalase (CAT). The results indicate that mannitol treatment significantly alleviates Hg‐induced phytotoxicity in lettuce by improving growth, enhancing photosynthetic efficiency, and modulating oxidative stress responses. This study highlights the potential of mannitol as a viable strategy for mitigating Hg pollution effects, offering new insights into its application for improving crop resilience under heavy metal stress.