bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rational Medium‐Range Charge Transfer Strategy Toward Highly Efficient Violet‐Blue Organic Light‐Emitting Diodes with Narrowed Emission
Authors: He Xin , Lou Jingli , Li Baoxi , Dong Xiaobin , Zhong Feiyang , Liu Wei , Feng Xing , Yang Dezhi , Ma Dongge , Zhao Zujin , Wang Zhiming , Tang Ben Zhong 
Published: November 2023

AbstractThe spectral narrowing engineering of pure‐organic emitters attracts great research interests in realizing high color purity. Here, the adjusted medium‐range charge transfer (MCT) strategy of TIC‐BO with rigid planar structure by fusing two typical UV‐emitting multiple resonance (MR) fragments via the ingenious double‐halide cyclized coupling reaction is reported. The resulting TIC‐BO with MCT nature shows efficient violet‐blue emission in dilute toluene and evaporated host–guest films, and desirably narrowed spectra are achieved by the suppression of structural relaxation and the shortened charge transfer states. The single‐doped device with TIC‐BO as emitter shows narrowed violet‐blue electroluminescence peaked at 428 nm with full‐width at half‐maximum of 43 nm (0.28 eV), and the Commission Internationale de l’Éclairage coordinates of (0.160, 0.050). A maximum external quantum efficiency (EQEmax) of 20.50% is achieved, which is among the best results of the corresponding violet‐blue emitting region. Further introduction of a stronger electron‐donating carbazole group makes TIC‐BNO exhibit red‐shifted sky‐blue emission with MR‐dominant properties, and good device performance is received with EQEmax of 34.58%. The outstanding performances of TIC‐BO successfully demonstrate the significance and prospect of the proposed molecular design strategy.
Spin‐Switchable Optics for Surface Plasmon Polaritons Utilizing Nanogroove‐Pair Array
Authors: Yang Xujun , Wang Jiayuan 
Published: November 2023

AbstractManipulating surface plasmon polaritons (SPPs) in a spin‐controlled manner has opened new possibilities in various applications. Generating spin‐switchable arbitrary complex wavefronts of SPPs using subwavelength structures is highly desirable. Here, the nanogroove‐pair unit (NP), a powerful structure enabling independent amplitude and phase control for spin‐encoded SPP generation, is introduced. Through an NP‐array structure, a comprehensive design strategy for generating SPPs with predefined wavefronts is presented for both left‐ and right‐handed circular polarizations. As an example, a plasmonic lens capable of spin‐switchable focusing is designed with an exceptionally high extinction ratio. Additionally, various complex wavefronts, such as bifocusing, nondiffracting beaming, asymmetric focusing, and focal length switching, all incorporating spin‐switchable features, are presented. The proposed scheme represents a significant advancement in polarization‐controlled wavefront shaping for SPPs, offering potential for diverse applications, including plasmonic switches, particle trapping and manipulation, and polarization sensing.
Asymmetric Overgrowth of Au/AuPt/PtSe2 and Au/AgPtSe2 Heterorods for Optimizing Nonlinear Enhancements
Authors: Dou Zhen‐Long , Cheng Li , Wu Zhi‐Yong , Chen Li‐Jiong , Zhou Li , Wang Qu‐Quan 
Published: November 2023

AbstractFavorable growth of asymmetric hetero‐nanostructures consisting of plasmonic metals and semiconductors or topological nanomaterials is highly desired because the performance of nonlinear optical antennas is closely related to their composition and morphology symmetry. In this work, two methods are proposed to overgrow PtSe2, a semiconductor or topological semimetal material, onto Au nanorods (AuNRs) to form Au/AuPt/PtSe2 and Au/AgPtSe2 heterorods via wet chemical technique. Both Au/AuPt/PtSe2 and Au/AgPtSe2 heterorods show asymmetric morphologies: the Au/AuPt/PtSe2 heterorods show a partially hollow morphology with an etched AuNR coated by AuPt and PtSe2 shells; the Au/AgPtSe2 heterorods prepared by Ag‐mediated overgrowth method have a toothbrush shape with AgPtSe2 attached on the side surface near one end of AuNRs. The two asymmetric heterorods show significantly enhanced nonlinear radiations of second harmonic generation with the excitation laser wavelength tuning from 1220 to 1315 nm, and a maximal nonlinear enhancement factor of 16 is achieved, which is attributed to the interaction of gold core with platinum selenide shell and the broken symmetry of heterostructures. The findings provide a strategy to prepare metal‐topological heterostructures as optical antennas with optimized performance in the application of nonlinear photonic nanodevices.
An Intrinsically Magnetic Epicardial Patch for Rapid Vascular Reconstruction and Drug Delivery
Authors: Qian Bei , Shen Ao , Huang Shixing , Shi Hongpeng , Long Qiang , Zhong Yiming , Qi Zhaoxi , He Xiaojun , Zhang Yecen , Hai Wangxi , Wang Xinming , Cui Yanna , Chen Ziheng , Xuan Huixia , Zhao Qiang , You Zhengwei , Ye Xiaofeng 
Published: November 2023

AbstractMyocardial infarction (MI) is a major cause of mortality worldwide. The major limitation of regenerative therapy for MI is poor cardiac retention of therapeutics, which results from an inefficient vascular network and poor targeting ability. In this study, a two‐layer intrinsically magnetic epicardial patch (MagPatch) prepared by 3D printing with biocompatible materials like poly (glycerol sebacate) (PGS) is designed, poly (ε‐caprolactone) (PCL), and NdFeB. The two‐layer structure ensured that the MagPatch multifariously utilized the magnetic force for rapid vascular reconstruction and targeted drug delivery. MagPatch accumulates superparamagnetic iron oxide (SPION)‐labelled endothelial cells, instantly forming a ready‐implanted organization, and rapidly reconstructs a vascular network anastomosed with the host. In addition, the prefabricated vascular network within the MagPatch allowed for the efficient accumulation of SPION‐labelled therapeutics, amplifying the therapeutic effects of cardiac repair. This study defined an extendable therapeutic platform for vascularization‐based targeted drug delivery that is expected to assist in the progress of regenerative therapies in clinical applications.
CAFs Homologous Biomimetic Liposome Bearing BET Inhibitor and Pirfenidone Synergistically Promoting Antitumor Efficacy in Pancreatic Ductal Adenocarcinoma
Authors: Zhang Yin , Yu Ranran , Zhao Cheng , Liang Jiawei , Zhang Yixuan , Su Haochen , Zhao Jing , Wu Hao , Xu Shijin , Zhang Ziying , Wang Lei , Zou Xiaoping , Zhu Yun , Zhang Shu , Lv Ying 
Published: November 2023

AbstractBRD4 is a member of the BET protein family involved in chromatin remodeling and transcriptional regulation. Several BET inhibitors (BETi) have entered clinical trials, demonstrating potential in inducing cancer cell apoptosis and tumor regression. However, resistance to BETi is common in solid tumors. In pancreatic cancer, it is found that cancer‐associated fibroblasts (CAFs) in the tumor microenvironment reduce the BET inhibitor JQ1 sensitivity by inducing BRD4 expression. Moreover, CAFs play a crucial role in the formation of a dense stromal barrier. Therefore, targeting CAFs in the tumor microenvironment of pancreatic cancer not only enhances cancer cells sensitivity to JQ1 but also increases drug perfusion and improves oxygen supply, thus reducing glycolysis and limiting energy supply. To address this challenge, a homologous targeting mechanism utilizing activated fibroblast membrane‐coated liposomes is proposed for specific drug precise target to CAFs‐rich pancreatic cancer. Additionally, TAT peptides enable liposomes penetration, delivering PFD for targeted anti‐fibrotic therapy, reducing extracellular matrix generation and glycolysis, and enhancing JQ1 delivery and sensitivity. In conclusion, the findings indicate the tremendous potential of this CAFs‐targeting liposomal delivery system in pancreatic cancer.
Shortcut design method for multicomponent gradient simulated moving beds
Authors: Frandsen Jesper , Huusom Jakob K. , Gernaey Krist V. , Abildskov Jens 
Published: November 2023

AbstractThis work describes a method for design (and verification) of isocratic and gradient simulated moving bed (SMB) chromatography, based on the triangle theory. The method is tested using both constant selectivity and nonconstant selectivity isotherms as well as implicit and explicit isotherms through the Linear, Langmuir, and SMA isotherms. The results show that the method is applicable to a wide range of isotherms and to multicomponent systems. The study also investigates the influence of modifier concentrations on gradient SMB performance, by determining the optimal flow rate ratios for calculating volume‐specific productivity and eluent consumption. These findings demonstrate the potential of the method to improve the performance of a gradient SMB and serve as a useful initial step in the design and optimization of operational flow rates and modifier concentrations.
The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy
Authors: Pierpont Elizabeth I. , Bennett Anton M. , Schoyer Lisa , Stronach Beth , Anschutz April , Borrie Sarah C. , Briggs Benjamin , Burkitt‐Wright Emma , Castel Pau , Cirstea Ion C. , Draaisma Fieke , Ellis Michelle , Fear Vanessa S. , Frone Megan N. , Flex Elisabetta , Gelb Bruce D. , Green Tamar , Gripp Karen W. , Khoshkhoo Sattar , Kieran Mark W. , Kleemann Karolin , Klein‐Tasman Bonita P. , Kontaridis Maria I. , Kruszka Paul , Leoni Chiara , Liu Clifford Z. , Merchant Nadia , Magoulas Pilar L. , Moertel Christopher , Prada Carlos E. , Rauen Katherine A. , Roelofs Renée , Rossignol Rodrigue , Sevilla Christine , Sevilla Gigi , Sheedy Ryan , Stieglitz Elliot , Sun Daochun , Tiemens Dagmar , White Forest , Wingbermühle Ellen , Wolf Cordula , Zenker Martin , Andelfinger Gregor 
Published: November 2023

AbstractGermline pathogenic variants in the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway are the molecular cause of RASopathies, a group of clinically overlapping genetic syndromes. RASopathies constitute a wide clinical spectrum characterized by distinct facial features, short stature, predisposition to cancer, and variable anomalies in nearly all the major body systems. With increasing global recognition of these conditions, the 8th International RASopathies Symposium spotlighted global perspectives on clinical care and research, including strategies for building international collaborations and developing diverse patient cohorts in anticipation of interventional trials. This biannual meeting, organized by RASopathies Network, was held in a hybrid virtual/in‐person format. The agenda featured emerging discoveries and case findings as well as progress in preclinical and therapeutic pipelines. Stakeholders including basic scientists, clinician‐scientists, practitioners, industry representatives, patients, and family advocates gathered to discuss cutting edge science, recognize current gaps in knowledge, and hear from people with RASopathies about the experience of daily living. Presentations by RASopathy self‐advocates and early‐stage investigators were featured throughout the program to encourage a sustainable, diverse, long‐term research and advocacy partnership focused on improving health and bringing treatments to people with RASopathies.
Dearomative Insertion of Fluoroalkyl Carbenes into Azoles Leading to Fluoroalkyl Heterocycles with a Quaternary Center
Authors: Li Linxuan , Ning Yongquan , Chen Hongzhu , Ning Yongyue , Sivaguru Paramasivam , Liao Peiqiu , Zhu Qingwen , Ji Yong , de Ruiter Graham , Bi Xihe 
Published: November 2023

AbstractThe skeletal ring expansion of heteroarenes through carbene insertion is gaining popularity in synthetic chemistry. Efficient strategies for heterocyclic ring expansion to access heterocycles containing a fluoroalkyl quaternary carbon center through fluoroalkyl carbene insertion are highly desirable because of their broad applications in medicinal chemistry. Herein, we report a general strategy for the dearomative one‐carbon insertion of azoles using fluoroalkyl N‐triftosylhydrazones as fluoroalkyl carbene precursors, resulting in ring‐expanded heterocycles in excellent yields with good functional‐group compatibility. The broad generality of this methodology in the late‐stage diversification of pharmaceutically interesting bioactive molecules and versatile transformations of the products has been demonstrated.
Synthesis of 2‐Azanorbornanes via Strain‐Release Formal Cycloadditions Initiated by Energy Transfer
Authors: Chang Yu‐Che , Salome Christophe , Fessard Thomas , Brown M. Kevin 
Published: November 2023

AbstractRigid bicycles are becoming more popular in the pharmaceutical industry because they allow for expansion to new and unique chemical spaces. This work describes a new strategy to construct 2‐azanorbornanes, which can act as rigid piperidine/pyrrolidine scaffolds with well‐defined exit vectors. To achieve the synthesis of 2‐azanorbornanes, new strain‐release reagent, azahousane, is introduced along with its photosensitized strain‐release formal cycloaddition with alkenes. Furthermore, new reactivity between a housane and an imine is disclosed. Both strategies lead to various substituted 2‐azanorbornanes with good selectivities.
Effect of the water content and the lengthening of fatty acids chain on the iCALB‐catalyzed esterification in deep eutectic solvents
Authors: Maurente Lorena , Callejas Nicolás , Volonterio Elisa , Baréa Bruno , Barouh Nathalie , Bourlieu‐Lacanal Claire , Durand Erwann , Villeneuve Pierre , Figueroa‐Espinoza Maria Cruz , Jachmanián Iván 
Published: November 2023

AbstractFour Deep Eutectic Solvents (DES) based on choline chloride (ChCl) and different hydrogen bond donors (1,4‐butanediol, glycerol, isosorbide, and urea) were tested as reaction medium for the immobilized Candida antarctica B (iCALB) lipase‐catalyzed esterification of fatty acids with n‐butanol. Although the strong hydrogen bonds between DES components were expected to lower their reactivity, all except urea, competed in the esterification reaction. To study the effect of acyl group donor and water, different chain length of saturated fatty acids (ranging from 6:0 to 18:0) and water content (ranging from 0, 1, 2 or 3 molar ratio of water/ChCl) were tested in the lipase‐catalyzed esterification with n‐butanol in ChCl:urea (1:2, molar ratio). When the incubation was performed in the absence of water, the shorter the fatty acid chain length, the higher the conversion. Upon water addition, a drastic increase in the esterification rate of all the fatty acids was observed and, conversely to what occurred in the anhydrous media, the longer the fatty acid chain length, the higher the conversion. Results suggest that water concentration in the DES medium possesses a multifactorial effect, as it influences the enzyme activity, the solvent viscosity, the DES structure, and the interaction between DES components, substrates, and enzymes, thus determining the efficiency and yield of the esterification reaction.
Preparation of carboxy sulfonic acid‐containing copolymer scale inhibitors and their scale inhibition effect on CaCO3
Authors: Ma Wentao , Hu Zhijie , Zhang Yu , Ma Jie , Xin Guopeng 
Published: November 2023

AbstractFree radical polymerization was selected to obtain a promising copolymer scale inhibitor IA‐AM‐SAS with good water solubility and temperature and salt resistance, which is suitable for the treatment of surface pipeline water in oil fields, using itaconic acid (IA), acrylamide (AM), and sodium acrylsulfonate (SAS) as the monomers. The structure of the synthesized copolymer was verified by Fourier transform infrared spectroscopy and nuclear magnetic resonance hydrogen spectroscopy. Thermogravimetric results showed that the copolymer does not undergo significant thermal degradation at temperatures below 356°C, indicating that the copolymer has good thermal stability. The molecular weights of the polymers at different monomer ratios were measured using gel permeation chromatography and the relationship between the molecular weights and scale inhibition performance was discussed. The results showed that the scale inhibition effect was best when the monomer molar ratio n(IA): n(AM): n(SAS) was 0.5:2:1.5 and the number of average molecular weight of the prepared copolymer was 7712 g/mol, and the inhibition efficiency of CaCO3 was 84.02% when IA‐AM‐SAS was at a concentration of 30 mg L−1, and the inhibition rate was measured by the standard of static scale inhibition test in the oilfield measured. The range of conditions (PH, Ca2+ concentration, water temperature, and time) of the static scale inhibition test was then expanded using a one‐way controlled variable experiment to explore the performance of IA‐AM‐SAS scale inhibitors under different water quality conditions. The scale inhibition mechanism was explored by scanning electron microscopy, x‐ray diffraction, and x‐ray photoelectron spectroscopy. Briefly, the combination of multiple functional groups enables IA‐AM‐SAS to be applied in complex and challenging environments.
Synthesis of β‐Hydroxysulfides via Multi‐Component Cascade Hydroxysulfenylation of Styrenes with NH4SCN and Water under Transition‐metal‐free Conditions
Authors: Liu Xian , Hao Liqiang , Wang Yangyang , Ji Yafei 
Published: November 2023

AbstractTransition‐mental‐free multi‐component hydroxysulfenylation of styrenes with NH4SCN and water to from β‐hydroxysulfides is established. The reaction mechanism proceeded via a domino reaction after a radical addition to 2‐phenylimidazo[1,2‐a]pyridines. This approach features a wide substrate scope and functional group compatibility, providing 34 compounds in acceptable yields.
The effect of recasting by mothers with different conversational styles on the communication behavior of autistic children: Lag sequential analysis
Authors: Li Xiaoyan , Peng Yonghan , Lu Yiting , Zhang Yumin 
Published: November 2023

AbstractRecasting is the adult rephrasing of a child's immediately preceding utterance. It has been shown to have outstanding effects on promoting language development in autistic children. This study used lag sequential analysis to explore the impact of mothers' conversational styles on the communicative behavior of autistic children when using recasting. This study recruited 30 Chinese autistic children (aged 3–6 years) and their mothers. The utterances of the children and their mothers during 30‐min interactions were transcribed, coded, and analyzed. The mothers' conversational styles were determined by the percentages of child‐dominant, mother‐dominant, and equality styles. The results indicated that mothers' conversational styles were predominantly child‐dominant, differing from the expected mother‐dominant style that is typical in Eastern cultures and traditions. However, some mothers still demonstrated a significant proportion of mother‐dominant style in their conversation, while some exhibited a considerable amount of equality style. Moreover, mothers with a mainly child‐dominant style and minimal use of mother‐dominant and equality styles used recasting after the child's response, triggering the child to initiate new topics. Mothers with a child‐dominant style combined with prominent mother‐dominant features implemented untargeted self‐recasting, the children did not respond significantly. Mothers with a child‐dominant style combined with prominent equality features used recasting after the children responded, initiated, or expanded the conversation, which often facilitated the child's expansion of the conversation. These findings provide suggestions for designing parent‐mediated early language interventions for autistic children.
Triboluminescence and crystal structure of the complex [Eu(MBA)3Dipy]2(HMBA)
Authors: Bukvetskii Boris V. , Kalinovskaya Irina V. 
Published: November 2023

AbstractThe atomic structure of the crystals [Eu(MBA)3Dipy]2(HMBA) (MBA–аnion toluic acid, Dipy–2,2′‐dipyridyl, HMBA–toluic acid), displaying intensive luminescence and triboluminescence was determined using single crystal X‐ray diffraction analysis. The triclinic centrosymmetric crystals have the following parameters: a = 10.620(2), b = 11.849(2), c = 14.9868(2) Å, α = 68.297(1), β = 76.172(1), γ = 80.378(1)°, sp.gr. P −1, Z = 1, ρcalc. = 1.537 g/cm3. The structure belongs to the insular type and is presented as the isolated complex Eu2‐dimeric formations and outer‐sphere HMBA. The structural aspects of the observed luminescence and triboluminescence properties of the compound were discussed, and the cleavage plane role in the process of the crystal destruction was revealed.
Kahoot: A game‐based web tool to assess motivation, engagement fun, and learning outcomes among engineers
Authors: Lashari Tahira A. , Fiayaz Rimsha , Lashari Saima A. , Khan Ijaz , Sultana Sidra , Afzal Tashfa 
Published: November 2023

AbstractIt can be very difficult and demanding to keep students interested and motivated to learn difficult concepts and ideas; this is especially true if the task seems difficult and unique to the students. The digital generation enjoys using mobile applications. The study's goal was to encourage instructors to use digital assessment tools and approaches to enhance students' psychological abilities, such as motivation, enjoyment, and performance in learning. The study used the educational technology application Kahoot for formative assessment. The main objective is to determine how the use of the online game “Kahoot” affects the students' motivation, enjoyment, engagement, concentration, and learning outcome, which is a supplement to traditional teacher‐centered learning. Quantitative research was carried out, volunteered participants were divided into two groups: Kahoot (n = 32) and paper‐based (n = 32), and were given lectures on a particular topic in mechanics for a specific period. Lately, quiz was conducted in groups; the participants in the Kahoot groups gave the test on Kahoot mobile application, while the student in the paper‐based group traditionally gave the quiz, data was collected from the participants in both groups using a Likert‐scale questionnaire to determine their perceptions of participants on the above‐stated themes. Then, the mean, standard deviation, z‐test and t‐test were used to determine the perceptions in both groups. The findings from the study ultimately agreed to the hypothesis that effective learning, motivation, engagement, and fun were all in the Kahoot‐based group compared to the paper‐based group with a statistically significant difference.