bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bisphosphonate–ciprofloxacin bound to Skelite™ is a prototype for enhancing experimental local antibiotic delivery to injured bone
Authors: Buxton T B , Walsh D S , Harvey S B , McPherson J C , Hartmann J F , Plowman K M 
Published: July 2004

AbstractBackgroundThe risk of osteomyelitis after open bone fracture may be reduced by locally applied antibiotics. ENC-41-HP (E41), which comprises ciprofloxacin linked to a ‘bone seeking’ bisphosphonate, loaded on to carrier Skelite™ calcium phosphate granules (E41-Skelite™) has favourable in vitro characteristics for application to wounded bone. This study assessed E41-Skelite™ in a rat model of acute tibial osteomyelitis.MethodsMechanically induced tibial troughs were contaminated with approximately log10 4 colony forming units (c.f.u.) of Staphylococcus aureus (Cowan 1 strain) ‘resistant’ to E41 (minimum inhibitory concentration 8–16 µg/ml), lavaged and packed with Skelite™ alone, or with E41-Skelite™ slurry. Animals were killed at 24 h (n = 62), 72 h (n = 46) or 14 days (n = 12), and each tibia was assessed for S. aureus load (c.f.u./g tibia) and histological appearance (14 days only).ResultsAt 24 and 72 h, the tibias of rats treated with E41-Skelite™ (n = 54) had a significantly lower mean(s.e.m.) load of S. aureus than animals that received Skelite™ alone (n = 54): log10 3·6(0·2) versus 6·4(0·1) c.f.u./g respectively at 24 h (P &lt; 0·001, Mann–Whitney rank sum test) and log10 4·4(0·2) versus 6·6(0·1) c.f.u./g at 72 h (P &lt; 0·001). At 14 days, E41-Skelite™-treated tibias had fewer bacteria, no signs of osteomyelitis and histological signs of healing.ConclusionE41-Skelite™, a prototype granulated topical antibiotic delivery system, reduced the development of infection in experimental bone wounds.
Clinical pharmacokinetic data of racemic drugs obtained by the indirect method following precolumn diastereomer formation: is the influence of racemization during chiral derivatization significant?
Authors: Srinivas Nuggehally R. 
Published: July 2004

AbstractThis report reviews the stereoselective data of a number of racemic drugs (n = 17) obtained from indirect chiral method (via diastereomer formation) in comparison to similar data generated by the application of a direct chiral method. While it was noted that the indirect method still continued to be used to characterize the stereoselective disposition of racemic drugs, the present review critically evaluates the issue of racemization that has the potential to skew the stereoselective data obtained from the indirect method. The review describes various remedies to counter and/or minimize the impact of racemization on the final outcome of the stereoselective analysis by the indirect method. On the basis of this review it could be concluded that the indirect method is a viable and important tool for gathering stereoselective data of racemic drugs used in medical practice as well for those racemic drugs still in discovery and developmental stages. Copyright © 2004 John Wiley & Sons, Ltd.
Relative Binding Affinities of Molecular Capsules Investigated by ESI‐Mass Spectrometry
Authors: Zadmard Reza , Kraft Arno , Schrader Thomas , Linne Uwe 
Published: July 2004

AbstractESI‐MS(/MS) has been used as a method which allows the fast, unambiguous and sensitive simultaneous detection and relative stability approximation of supramolecular assemblies in mixtures. In spite of the obvious fundamental differences between solution and gas phase, ESI‐MS in the case of self‐assembled molecular capsules has been shown to produce very similar results to single binding experiments monitored by NMR titrations as well as conformational searches performed by Monte‐Carlo simulations. MS/MS experiments reveal the same relative order of gas phase stabilities as previously found in solution. Moreover, proton transfer reactions which lead to new molecular capsules, are not detectable in the time‐averaged NMR spectrum. However, the newly produced species are found in the complex mixtures by ESI‐MS and can be conveniently characterized by subsequent MS/MS experiments: in a collision‐induced dissociation the single half‐spheres are easily discovered and structurally assigned. Thus, ESI‐MS has worked as a valuable tool for the rapid screening of complex supramolecular mixtures and in combination with MS/MS experiments elucidated both the path of unexpected side reactions as well as the thermodynamic gas‐phase stabilities of all components in the mixture.
Effect of Conformational Changes on a One‐Electron Reduction Process: Evidence of a One‐Electron PP Bond Formation in a Bis(phosphinine)
Authors: Choua Sylvie , Dutan Cosmina , Cataldo Laurent , Berclaz Théo , Geoffroy Michel , Mézailles Nicolas , Moores Audrey , Ricard Louis , Le Floch Pascal 
Published: July 2004

AbstractEPR spectra show that one‐electron reduction of bis(3‐phenyl‐6,6‐(trimethylsilyl)phosphinine‐2‐yl)dimethylsilane (1) on an alkali mirror leads to a radical anion that is localized on a single phosphinine ring, whereas the radical anion formed from the same reaction in the presence of cryptand or from an electron transfer with sodium naphthalenide is delocalized on the two phosphinine rings. Density functional theory (DFT) calculations show that in the last species the unpaired electron is mainly confined in a loose PP bond (3.479 Å), which results from the overlap of two phosphorus p orbitals. In contrast, as attested by X‐ray spectroscopy, the PP distance in neutral 1 is large (5.8 Å). As shown by crystal structure analysis, addition of a second electron leads to the formation of a classical PP single bond (PP 2.389 Å). Spectral modifications induced by the presence of cryptand or by a change in the reaction temperature are consistent with the formation of a tight ion pair that stabilizes the radical structure localized on a single phosphinine ring. It is suggested that the structure of this pair hinders internal rotation around the CSi bonds and prevents 1 from adopting a conformation that shortens the intramolecular PP distance. The ability of the phosphinine radical anion to reversibly form weak PP bonds with neutral phosphinines in the absence of steric hindrance is confirmed by EPR spectra obtained for 2,6‐bis(trimethylsilyl)‐3‐phenylphosphinine (2). Moreover, as shown by NMR spectroscopy, in this system, which contains only one phosphinine ring, further reduction leads to an intermolecular reaction with the formation of a classical PP bond.
Unprecedented Polymerization of ε‐Caprolactone Initiated by a Single‐Site Lanthanide Borohydride Complex, [Sm(η‐C5Me5)2(BH4)(thf)]: Mechanistic Insights
Authors: Palard Isabelle , Soum Alain , Guillaume Sophie M. 
Published: July 2004

AbstractThe monoborohydride lanthanide complex [Sm(Cp*)2(BH4)(thf)] (1 a) (Cp* = η‐C5Me5), has been successfully used for the controlled ring‐opening polymerization of ε‐caprolactone (ε‐CL). The organometallic samarium(III) initiator 1 a produces, in quantitative yields, α,ω‐dihydroxytelechelic poly(ε‐caprolactone) displaying relatively narrow polydispersity indices (<1.3) within a short period of time (30 min). The polymers have been characterized by 1H and 13C NMR, SEC, and MALDI‐TOF MS analyses. Use of the single‐site initiator 1 a allows a better understanding of the polymerization mechanism, in particular with the identification of the intermediate compound [Sm(Cp*)2(BH4)(ε‐CL)] (1 b). Indeed, one molecule of ε‐CL initially displaces the coordinated THF in 1 a to give 1 b. Then, ε‐CL opening (through cleavage of the cyclic ester oxygen–acyl bond) and insertion into the SmHBH3 bond followed by reduction of the carbonyl function by the BH3 end‐group ligand, leads to the samarium alkoxyborane derivative [Sm(Cp*)2{O(CH2)6O(BH2)}] (2). This compound subsequently initiates the polymerization of ε‐CL through a coordination–insertion mechanism. Finally, upon hydrolysis, α,ω‐dihydroxypoly(ε‐caprolactone), HO(CH2)5C(O){O(CH2)5C(O)}nO(CH2)6OH (4) is recovered. The stereoelectronic contribution of the two Cp* ligands appears to slow down the polymerization and to limit transesterification reactions.
Synthesis, Crystal Structure, and Characterization of Ba(Ti1/2Mn1/2)O3: A High Permittivity 12R‐Type Hexagonal Perovskite.
Authors: Keith Gillian M. , Kirk Caroline A. , Sarma Kumaravinothan , Alford Neil McN. , Cussen Edmund J. , Rosseinsky Matthew J. , Sinclair Derek C. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ternary Indides LnMgIn (Ln: Y, La—Nd, Sm, Gd—Tm, Lu). Synthesis, Structure and Magnetic Properties.
Authors: Kraft Rainer , Valldor Martin , Kurowski Daniel , Hoffmann Rolf‐Dieter , Poettgen Rainer 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Crystal Growth and Crystal Structure Determination of K2[Pt(CN)4Cl2], K2[Pt(CN)4Br2], K2[Pt(CN)4I2] and K2[Pt(CN)4]Cl2×2H2O.
Authors: Muehle Claus , Karpov Andrey , Nuss Juergen , Jansen Martin 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Boron Nitride Whiskers: Showing Strong Ultraviolet and Visible Light Luminescence.
Authors: Zhu Ying‐Chun , Bando Yoshio , Xue Dong‐Feng , Sekiguchi Takashi , Golberg Dmitri , Xu Fang‐Fang , Liu Quan‐Lin 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Molecule Derived Synthesis of Nanocrystalline YFeO3 and Investigations on Its Weak Ferromagnetic Behavior.
Authors: Mathur Sanjay , Veith Michael , Rapalaviciute Rasa , Shen Hao , Goya Gerardo F. , Martins Filho Waldir L. , Berquo Thelma S. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterization of the First Organically Templated Layered Cerium Phosphate Fluoride: [(CH2)2(NH3)2]0.5 [CeIVF3(HPO4)].
Authors: Yu Ranbo , Wang Dan , Ishiwata Shintaro , Saito Takashi , Azuma Masaki , Takano Mikio , Chen Yunfa , Li Jinghai 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
[{Zn(enMe)2}2 (enMe)2{Zn2As8V12O40 (H2O)}]× 4H2O: A Hybrid Molecular Material Based on Covalently Linked Inorganic Zn—As—V Clusters and Transition Metal Complexes via enMe Ligands.
Authors: Zheng Shou‐Tian , Zhang Jie , Yang Guo‐Yu 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
[SiNb12O40]16‐ and [GeNb12O40]16‐: Highly Charged Keggin Ions with Sticky Surfaces.
Authors: Nyman May , Bonhomme Francois , Alam Todd M. , Parise John B. , Vaughan Gavin M. B. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Soluble μ‐Fi Bridged Niobium Clusters: Synthesis and Crystal Structures of (Et4N)6 [Nb6F6iBr6i (NCS)6a]Br2 and Cs1.6K2.4 [Nb6F6iI6i (NCS)6a].
Authors: Naumov Nikolai G. , Cordier Stephane , Perrin Christiane 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diels—Alder Cycloadditions of Functionalized (Z)‐1‐Benzylidene‐2‐methylene Cyclohexanes: The Beneficial Effect of High Pressure.
Authors: Lomberget Thierry , Chataigner Isabelle , Bouyssi Didier , Maddaluno Jacques , Balme Genevieve 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
5‐Aryl‐2‐furaldehydes in the Synthesis of 2‐Substituted 1,3‐Benzazoles.
Authors: Ganushchak N. I. , Lesyuk A. I. , Fedorovich I. S. , Obushak N. D. , Andrushko V. N. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 1‐Benzothiepine and 1‐Benzazepine Derivatives as Orally Active CCR5 Antagonists.
Authors: Aramaki Yoshio , Seto Masaki , Okawa Tomohiro , Oda Tsuneo , Kanzaki Naoyuki , Shiraishi Mitsuru 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Design, Synthesis and Structure—Activity Relationship of Novel RXR‐Selective Modulators.
Authors: Michellys Pierre‐Yves , D'Arrigo Jennifer , Grese Timothy A. , Karanewsky Donald S. , Leibowitz Mark D. , Mais Dale A. , Mapes Christopher M. , Reifel‐Miller Anne , Rungta Deepa , Boehm Marcus F. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ecofriendly Solid‐State Oxidative Deprotection of 1,3‐Dithianes and 1,3‐Dithiolanes Using Ammonium Persulfate on Wet Montmorillonite K‐10 Clay Support under Microwave Irradiation.
Authors: Ganguly Nemai C. , Datta Mrityunjoy 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction of β‐Ethoxyvinyl Lithium Generated from Phenyltellanyl‐ and Ethyltellanylacetaldehyde Diethyl Acetals with Aldehydes and Ketones and Successive Hydrations.
Authors: Yoshimatsu Mitsuhiro , Hatanaka Fumihiro 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Functionalization of the Methyl Ketone Fragment in 1‐[(1S,3R)‐2,2‐Dimethyl‐3‐(2‐methoxymethyloxyethyl)cyclopropyl] ‐2‐propanone.
Authors: Gimalova F. A. , Sadretdinov I. F. , Spirikhin L. V. , Miftakhov M. S. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Synthesis of 2‐Alkoxy‐3‐hydroxytropones and 2,7‐Dihydroxytropones from Dialkoxy‐8‐oxabicyclo[3.2.1]oct‐6‐en‐3‐ones.
Authors: Zinser Hartmut , Henkel Sonja , Foehlisch Baldur 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiinflammatory Activity of N‐[2‐(p‐Hydroxyphenyl)‐1,1‐dialkylethyl] ‐α‐dialkylaminoacetamides.
Authors: Glushkov V. A. , Anikina L. V. , Vikharev Yu. B. , Stryapunina O. G. , Shklyaev Yu. V. , Tolstikov A. G. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Sequential Highly Stereoselective Hydroboration and Suzuki—Miyaura Cross‐Coupling Reaction of Fluoroalkylated Internal Acetylenes: A Practical One‐Pot Synthesis of Fluoroalkylated Trisubstituted Alkenes.
Authors: Konno Tsutomu , Chae Jungha , Tanaka Tomoo , Ishihara Takashi , Yamanaka Hiroki 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Spectral Properties of N‐Aryl‐5‐hydroxy‐1,4‐naphthoquinone 4‐Imines.
Authors: Bukhtoyarova A. D. , Ektova L. V. , Alekseev S. N. , Beregovaya I. V. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Carbocationic Cyclizations. Part 9. Rearrangement of Long‐Lived 4‐(2‐Biphenylyl)‐1,2,3,4‐tetramethylcyclobutenyl Cation into trans‐ and cis‐4,5,6,6‐Tetramethyl‐4,5,6‐trihydrocyclopenta[j,k]phenanthren‐5‐yl Cations.
Authors: Bushmelev V. A. , Genaev A. M. , Osadchii S. A. , Shakirov M. M. , Shubin V. G. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
α‐Oxoketene Dithioacetals Mediated Heteroaromatic Annulation Protocol for Benzoheterocycles: An Efficient Regiocontrolled Synthesis of Highly Substituted and Annulated Indazoles.
Authors: Peruncheralathan S. , Khan T. A. , Ila H. , Junjappa H. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Fine‐Tuned Aminal Cleavage: A Concise Route to Differentially Protected Enantiopure syn‐α,β‐Diamino Esters.
Authors: Viso Alma , Fernandez de la Pradilla Roberto , Lopez‐Rodriguez Maria L. , Garcia Ana , Flores Aida , Alonso Marta 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Method for the Synthesis of 2(3H)‐Benzimidazolones, 2(3H)‐Benzoxazolone, and 2(3H)‐Benzothiazolone via in situ Generated ortho Substituted Benzoic Acid Azides: Application of Ammonium Azide and Vilsmeier Complex for Acid Azide Generation.
Authors: Sridhar Radhakrishnan , Perumal Paramasivan T. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Structure and Properties of N‐Acetylated Derivatives of Methyl 5‐Amino‐1H‐[1,2,4]triazole‐3‐carboxylate.
Authors: Dzygiel Anetta , Rzeszotarska Barbara , Masiukiewicz Elzbieta , Cmoch Piotr , Kamienski Bohdan 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
4‐Aryl(benzyl)amino‐4‐heteroarylbut‐1‐enes as Building Blocks in Heterocyclic Synthesis. Part 4. Synthesis of 4,6‐Dimethyl‐5‐nitro(amino)‐2‐pyridylquinolines and Their Antiparasitic Activities.
Authors: Kouznetsov Vladimir V. , et al. et al. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Tetrahydroacridin‐9‐ones, 9‐Chlorotetrahydroacridines, 9‐Amino‐tetrahydroacridines and 9‐(Pyrazol‐1‐yl)‐tetrahydroacridines Derived from Chiral Cyclanones.
Authors: Frideling Aline , Faure Robert , Galy Jean‐Pierre , Kenz Ahmed , Alkorta Ibon , Elguero Jose 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses and EGFR Kinase Inhibitory Activity of 6‐Substituted‐4‐anilino [1,7] and [1,8] Naphthyridine‐3‐carbonitriles.
Authors: Wissner Allan , Hamann Philip R. , Nilakantan Ramaswamy , Greenberger Lee M. , Ye Fei , Rapuano Timothy A. , Loganzo Frank 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
5‐Amino‐2H‐pyran‐3(6H)‐one. Part 1. A Convenient Intermediate in the Synthesis of Pyran Containing 1,4‐Dihydropyridines.
Authors: Altenbach Robert J. , Agrios Konstantinos , Drizin Irene , Carroll William A. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation of New Nitrogen‐Bridged Heterocycles. Part 55. Reinvestigation of the Bromination/Dehydrobromination of Ethyl 3‐[2‐(Methylthio)indolizin‐3‐yl]acrylate Derivatives.
Authors: Kakehi Akikazu , Ito Suketaka , Suga Hiroyuki , Kobayashi Yuhichi , Zuo Peng , Iriye Ryozo 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Pyridazine Derivatives. Part 38. Efficient Heck Alkenylation at Position 5 of the 6‐Phenyl‐3(2H)‐pyridazinone System.
Authors: Coelho Alberto , Sotelo Eddy , Novoa Hector , Peeters Oswald M. , Blaton Norbert , Ravina Enrique 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Simple and Efficient Synthesis of new 6‐Arylimino‐6H‐indolo[2,1‐b]quinazolin‐12‐ones under Microwave Irradiation.
Authors: Azizian Javad , Mohammadi Ali A. , Ardakani F. , Karimi Ali R. , Mohammadizadeh Mohammad R. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, anti‐Mycobacterial, anti‐Trichomonas and anti‐Candida in vitro Activities of 2‐Substituted‐6,7‐difluoro‐3‐methylquinoxaline 1,4‐Dioxides.
Authors: Carta Antonio , Loriga Mario , Paglietti Giuseppe , Mattana Antonella , Fiori Pier Luigi , Mollicotti Paola , Sechi Leonardo , Zanetti Stefania 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Microwave Irradiation for Accelerating Each Step for the Synthesis of 1,2,4‐Triazino[5,6‐b]indole‐3‐thiols and Their Derivatives from Isatin and 5‐Chloroisatin.
Authors: El Ashry El Sayed H. , Ramadan El Sayed , Abdel Hamid Hamida M. , Hagar Mohamed 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Approach to the Synthesis of Cytotoxic C2—C3 Unsaturated Pyrrolo[2,1‐c][1,4]benzodiazepines (PBDs) with Conjugated Acrylyl C2‐Substituents.
Authors: Chen Zhizhi , Gregson Stephen J. , Howard Philip W. , Thurston David E. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Selective Reduction of Aromatic Azides with Hexamethyldisilathiane: Synthesis of New 2‐Azidopyrrolo[2,1‐c][1,4]benzodiazepines.
Authors: Kamal Ahmed , Reddy K. Laxma , Reddy G. Suresh Kumar , Reddy B. S. Narayan 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two Contrasting Ethynyl Hydroboration Pathways in the Formation of a Novel Tris‐hydroboration Product from Reaction of Dimesitylborane with 2,5‐Diethynylpyridine.
Authors: Entwistle Christopher D. , Batsanov Andrei S. , Howard Judith A. K. , Fox Mark A. , Marder Todd B. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Lewis Acid Catalyzed Aza‐Diels—Alder versus Mannich Reactions of N‐Diethyl Phosphoryl Imino Dienophiles with Oxygenated Dienes and Application of a Chiral Lewis Acid.
Authors: Di Bari Lorenzo , Guillarme Stephane , Hermitage Stephen , Howard Judith A. K. , Jay David A. , Pescitelli Gennaro , Whiting Andrew , Yufit Dmitrii S. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Orthogonally Protected 2‐Deoxystreptamine Stereoisomers.
Authors: Verhelst Steven H. L. , Wennekes Tom , van der Marel Gijsbert A. , Overkleeft Herman S. , van Boeckel Constant A. A. , van Boom Jacques H. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Total Synthesis Without Protection: Three‐Step Synthesis of Optically Active Clavicipitic Acids by a Biomimetic Route.
Authors: Yokoyama Yuusaku , Hikawa Hidemasa , Mitsuhashi Masaharu , Uyama Aki , Hiroki Yasuhiro , Murakami Yasuoki 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Three‐Component Sequential Aza[4 + 2] Cycloaddition/Allylboration/Retro‐Sulfinyl‐Ene Reaction: A New Stereocontrolled Entry to Palustrine Alkaloids and Other 2,6‐Disubstituted Piperidines.
Authors: Toure Barry B. , Hall Dennis G. 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
2‐(N‐Acyl) and 2‐N‐Acyl‐N6‐substituted Analogues of Adenosine and Their Affinity at the Human Adenosine Receptor.
Authors: Jagtap Prakash G. , Chen Zhiyu , Szabo Csaba , Klotz Karl‐Norbert 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Absolute Stereochemistry of Immunosuppressive Macrolide Brasilinolide A (Ia) and Its New Congener Brasilinolide C (Ib).
Authors: Komatsu Kazusei , Tsuda Masashi , Tanaka Yasushi , Mikami Yuzuru , Kobayashi Jun'ichi 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antifungal Activity of Novel 14‐Membered Benzomacrolides as Galbonolide Analogues.
Authors: Sakoh Hiroki , Sakuraba Shunji , Sugimoto Yuichi , Imamura Hideaki , Jona Hideki , Yamada Koji , Bamba‐Nagano Rie , Hashizume Terutaka , Morishima Hajime 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and in vitro Antimycobacterial Activity of Novel 3‐(1H‐Pyrrol‐1‐yl)‐2‐oxazolidinone Analogues of PNU‐100480.
Authors: Sbardella Gianluca , Mai Antonello , Artico Marino , Loddo Roberta , Setzu Maria Grazia , La Colla Paolo 
Published: July 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Real‐time primer design for DNA chips
Authors: Simmler H. , Singpiel H. , Männer R. 
Published: July 2004

AbstractThe design of PCR or DNA chip experiments is a time‐consuming process where bioinformatics is extensively used. The selection of the primers, which are immobilized on the DNA chip, requires a complex algorithm. Based on several parameters an optimized set of primers is automatically determined for a given gene sequence.This paper describes a parallel architecture which performs the optimization of the primer selection on a hardware accelerator. In contrast to the pure software approach, the parallel architecture gains a speedup of factor 500 using a PCI‐based hardware accelerator. This approach allows an optimization of a specified primer set in real time. Copyright © 2004 John Wiley & Sons, Ltd.
Parallelization of IBD computation for determining genetic disease maps
Authors: Rizk Nouhad J. 
Published: July 2004

AbstractA number of software packages are available for the construction of comprehensive human genetic maps. In this paper we parallelize the widely used package Genehunter. We restrict our attention to only one function of the package, namely the computations of Identity By Descent (IBD) genes of a family. We use a master–slave model with the Message Passing Interface parallel environment. Our tests are done on two different architectures: a network of workstations and a shared memory multiprocessor. A new and efficient strategy to classify the parallelization of genetic linkage analysis programs results from our experiments. The classification is based on values of parameters which affect the complexity of the computation. Copyright © 2004 John Wiley & Sons, Ltd.