bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abdominal sacrocolpopexy for vault prolapse without burial of mesh: a case series
Authors: Elneil Sohier , Cutner Alfred S. , Remy Mary , Leather Andrew T. , Toozs‐Hobson Philip , Wise Brian 
Published: March 2005

Objectives  To audit the clinical outcome of abdominal vault suspension (sacrocolpopexy, hysteropexy or cervicopexy) using non‐absorbable mesh, without burial by closure of the peritoneum.Design  A case series.Setting  Urogynaecology units of four hospitals.Population  One hundred and twenty‐eight women having open or laparoscopic sacrocolpopexy (121), hysteropexy (6) or cervicopexy (1) using non‐absorbable mesh for vault prolapse.Methods  Patients had suspension of the vault, uterus or cervix from the sacral promontory using a monofilament polypropylene mesh. The pelvic peritoneum was not closed over the mesh. Patients were followed up every six months.Main outcome measures  Incidence of bowel complications as a consequence of the mesh; cure rate of prolapse and incidence of other post‐operative complications; rate of re‐operation for prolapse or incontinence.Result  After a median follow up of 19 months (1.5–62), there were no bowel complications as a result of non‐burial of mesh. Three patients had asymptomatic vaginal mesh erosion, which required minor surgical intervention. Ninety percent of patients had good resolution of their prolapse symptoms while 10% of patients required further surgery.Conclusion  Leaving the mesh uncovered by the pelvic peritoneum was not associated with complications. It appears safe to perform vault suspension without closing the peritoneum.
Marked fetal acidosis and specific changes in power spectrum analysis of fetal heart rate variability recorded during the last hour of labour
Authors: Siira Saila M. , Ojala Tiina H. , Vahlberg Tero J. , Jalonen Jarmo O. , Välimäki Ilkka A. , Rosén Karl G. , Ekholm Eeva M. 
Published: March 2005

Objective  To assess whether intrapartum acidosis affects specific components of fetal heart rate variability.Design  Prospective clinical study.Setting  Twelve Nordic delivery units.Subjects  Fetal heart rate variability was studied in 334 fetuses divided into two groups according to cord pH value: the acidotic group (cord arterial pH <7.05 at birth, n= 15) and the control group (cord arterial pH ≥7.05 at birth, n= 319).Methods  In spectral analysis of fetal heart rate variability, frequencies were integrated over the total frequency band (0.04–1.0 Hz), low‐frequency band (0.04–0.15 Hz) and high‐frequency band (0.15–1.0 Hz). We also calculated the low‐to‐high frequency ratio.Main outcome measures  The spectral bands of fetal heart rate variability were compared between the acidotic and control fetuses.Results  We found that during the last hour of monitoring, baseline fetal heart rate gradually decreased, whereas total, low‐frequency and high‐frequency fetal heart rate variability initially increased but then, near the delivery, decreased in the acidotic fetuses when compared with the controls. Low‐to‐high frequency ratio was greater in the acidotic group during the whole study period (P= 0.002). Cord artery pH was inversely associated with total fetal heart rate variability (P < 0.001), low‐frequency fetal heart rate variability (P < 0.001) and low‐to‐high frequency ratio (P= 0.004).Conclusions  Marked fetal acidosis was associated with frequency‐specific changes in fetal heart rate variability as reflecting the compensation ability of autonomic nervous activation during the last hour of labour.
Predictive factors for fibroids recurrence after uterine artery embolisation
Authors: Marret Henri , Cottier Jean Philippe , Alonso Ana Maria , Giraudeau Bruno , Body Gilles , Herbreteau Denis 
Published: March 2005

Objectives  To assess clinical failure and symptom recurrence after uterine artery embolisation (UAE) and to define predictive factors.Design  Prospective study of a case series.Setting  Gynaecology and radiology departments of a French University Hospital.Population  Eighty‐five women who underwent embolisation for the treatment of uterine fibroids.Method  Vascular access was obtained via the right common femoral artery. Free‐flow embolisation was performed using 150–250 μm polyvinyl alcohol particles and an absorbable particle sponge.Main outcome measures  Clinical failure was defined as persistence of symptoms at three months of follow up and recurrence as return of symptoms. The main outcome measure was the need for further treatment after UAE.Results  Results are available for 81 patients. Median follow up was 30 months. There were 15 clinical failures and recurrences requiring further treatment (eight hysterectomies, five hysteroscopic resections for submucous fibroids, one second embolisation and one woman refusing further treatment). Recurrence‐free survival rate at 30 months (no clinical failure, no recurrence) was 82.8% (95% CI 73.7–91.8%). Multivariate analysis identified two predictive factors: dominant fibroid size on ultrasound imaging (each 1 cm increase: HR = 1.68, 95% CI 1.10–2.69) and number of fibroids (each additional fibroid: HR = 1.34, 95% CI 1.08–1.66).Conclusions  Symptom recurrence rate 30 months after fibroid embolisation was 17.2%. Fibroid size and number were predictive factors for recurrence. As most recurrences occurred after two years, we recommend that patients be monitored clinically and that imaging be for more than two years after UAE.
Injuries in Swedish elite football—a prospective study on injury definitions, risk for injury and injury pattern during 2001
Authors: Waldén Markus , Hägglund Martin , Ekstrand Jan 
Published: March 2005

The purpose of this study was to study the risk for injury and injury pattern in Swedish male elite football and to compare two different injury definitions. A prospective cohort study was conducted during 2001 on all 14 teams (310 players) in the Swedish top division. Injuries and individual exposure were recorded. Injury was defined as time‐lost injury (715 injuries) and for comparison as tissue injury (765 injuries). No significant difference in the risk for injury between tissue injuries and time‐lost injuries was found during matches (27.2 vs. 25.9 injuries per 1000 match hours, P=0.66) or training sessions (5.7 vs. 5.2 injuries per 1000 training hours, P=0.65). The risk for injury during training was significantly higher during the pre‐season compared with the competitive season (P=0.01).Thigh strain was the single most common injury (14%). Knee sprain was the most common major injury (absence >4 weeks). Overuse injuries and re‐injuries were frequent and constituted 37% and 22% of all injuries. Re‐injuries caused significantly longer absence than their corresponding initial injuries (P=0.02). The risk for re‐injury (P=0.02) and overuse injury (P<0.01) was significantly higher during the pre‐season compared with the competitive season.
Inflammation suppressor genes: please switch out all the lights
Authors: Wells Christine A , Ravasi Timothy , Hume David A 
Published: March 2005

AbstractAn effective immune system requires rapid and appropriate activation of inflammatory mechanisms but equally rapid and effective resolution of the inflammatory state. A review of the canonical host response to gram-negative bacteria, the lipopolysaccharide-Toll-like receptor 4 signaling cascade, highlights the induction of repressors that act at each step of the activation process. These inflammation suppressor genes are characterized by their induction in response to pathogen, typically late in the macrophage activation program, and include an expanding class of dominant-negative proteins derived from alternate splicing of common signaling components. Despite the expanse of anti-inflammatory mechanisms available to an activated macrophage, the frailty of this system is apparent in the large numbers of genes implicated in chronic inflammatory diseases. This apparent lack of redundancy between inflammation suppressor genes is discussed with regard to evolutionary benefits in generating a heterogeneous population of immune cells and consequential robustness in defense against new and evolving pathogens.
Systematic Review of the Diagnosis and Management of Malignant Extradural Spinal Cord Compression: The Cancer Care Ontario Practice Guidelines Initiative‘s Neuro-Oncology Disease Site Group
Authors: Loblaw D. Andrew , Perry James , Chambers Alexandra , Laperriere Normand J. 
Published: March 2005

Purpose This systematic review describes the diagnosis and management of adult patients with a suspected or confirmed diagnosis of extradural malignant spinal cord compression (MSCC). Methods MEDLINE, CANCERLIT, and the Cochrane Library databases were searched to January 2004 using the following terms: spinal cord compression, nerve compression syndromes, spinal cord neoplasms, clinical trial, meta-analysis, and systematic review. Results Symptoms for MSCC include sensory changes, autonomic dysfunction, and back pain; however, back pain was not predictive of MSCC. The sensitivity and specificity for magnetic resonance imaging (MRI) range from 0.44 to 0.93 and 0.90 to 0.98, respectively, in the diagnosis of MSCC. The sensitivity and specificity for myelography range from 0.71 to 0.97 and 0.88 to 1.00, respectively. A randomized study detected higher ambulation rates in patients with MSCC who received high-dose dexamethasone before radiotherapy (RT) compared with patients who did not receive corticosteroids before RT (81% v 63% at 3 months, respectively; P = .046). There is no direct evidence that supports or refutes the type of surgery patients should have for the treatment of MSCC, whether surgical salvage should be attempted if patient is progressing on or shortly after RT, and whether patients with spinal instability should be treated with surgery. Conclusion Patients with symptoms of MSCC should be managed to minimize treatment delay. MRI is the preferred imaging technique. Treatment for patients with MSCC should consider pretreatment ambulatory status, comorbidities, technical surgical factors, the presence of bony compression and spinal instability, potential surgical complications, potential RT reactions, and patient preferences.
Expression of the Caudal-Type Homeodomain Transcription Factors CDX 1/2 and Outcome in Carcinomas of the Ampulla of Vater
Authors: Hansel Donna E. , Maitra Anirban , Lin John W. , Goggins Michael , Argani Pedram , Yeo Charles J. , Piantadosi Steven , Leach Steven D. , Biankin Andrew V. 
Published: March 2005

Purpose Adenocarcinomas of the ampulla of Vater demonstrate a characteristic histology but vary significantly in outcome. As a consequence, prognostic factors for these cancers are poorly defined. The caudal-type homeodomain transcription factors 1 (CDX1) and 2 (CDX2) regulate axial development and intestinal differentiation. We assessed the expression of these putative intestinal epithelial-specific transcription factors and their influence on patient outcome. Patients and Methods Fifty-three resected carcinomas of the ampulla of Vater, 31 pancreatic ductal adenocarcinomas, and 15 extrahepatic biliary carcinomas were analyzed for CDX1 and CDX2 expression using immunohistochemistry. Results Forty percent of carcinomas of the ampulla of Vater but less than 5% of pancreatic and biliary adenocarcinomas expressed CDX. Expression of CDX was associated with a better prognosis (P = .0009). Individually, both CDX1 (P = .02) and CDX2 (P = .02) expression were associated with a survival advantage on univariate analysis. Advanced T stage (P = .02), lymph node metastases (P = .004), and vascular space invasion (P = .0009) were associated with a poor prognosis. Multivariate analysis revealed vascular space invasion (P = .01) and CDX expression (P = .01) to be independent prognostic factors. Conclusion Expression of CDX was an independent marker of outcome in patients with resected adenocarcinoma of the ampulla of Vater. Expression of CDX may distinguish good prognosis intestinal-like tumors, which potentially arise within intestinal epithelium, from poorer prognosis pancreatobiliary tumors, which arise in adjacent pancreatic and/or biliary ductal epithelium.
Graft-Versus-Tumor Effects After Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning
Authors: Baron Frédéric , Maris Michael B. , Sandmaier Brenda M. , Storer Barry E. , Sorror Mohamed , Diaconescu Razvan , Woolfrey Ann E. , Chauncey Thomas R. , Flowers Mary E.D. , Mielcarek Marco , Maloney David G. , Storb Rainer 
Published: March 2005

PurposeWe have used a nonmyeloablative conditioning regimen consisting of total-body irradiation (2 Gy) with or without fludarabine (30 mg/m2/d for 3 days) for related and unrelated hematopoietic cell transplantation (HCT) in patients with hematologic malignancies who were not candidates for conventional HCT because of age, medical comorbidities, or preceding high-dose HCT. This approach relied on graft-versus-tumor (GVT) effects for control of malignancy.Patients and MethodsWe analyzed GVT effects in 322 patients given grafts from HLA-matched related (n = 192) or unrelated donors (n = 130).ResultsOf the 221 patients with measurable disease at HCT, 126 (57%) achieved complete (n = 98) or partial (n = 28) remissions. In multivariate analysis, there was a higher probability trend of achieving complete remissions in patients with chronic extensive graft-versus-host disease (GVHD; P = .07). One hundred eight patients (34%) relapsed or progressed. In multivariate analysis, achievement of full donor chimerism was associated with a decreased risk of relapse or progression (P = .002). Grade 2 to 4 acute GVHD had no significant impact on the risk of relapse or progression but was associated with increased risk of nonrelapse mortality and decreased probability of progression-free survival (PFS). Conversely, extensive chronic GVHD was associated with decreased risk of relapse or progression (P = .006) and increased probability of PFS (P = .003).ConclusionNew approaches aimed at reducing the incidence of grade 2 to 4 acute GVHD might improve survival after allogeneic HCT after nonmyeloablative conditioning.
Early separation anxiety and adult attachment style in women with eating disorders
Authors: Troisi Alfonso , Massaroni Paola , Cuzzolaro Massimo 
Published: March 2005

Objective. To ascertain whether women with eating disorders have a higher frequency of separation anxiety symptoms in childhood, and a higher prevalence of insecure styles of adult attachment, compared with healthy women.Methods. The Separation Anxiety Symptom Inventory (SASI) and the Attachment Style Questionnaire (ASQ) were administered to 78 women with eating disorders and 64 healthy women.Results. Compared with control women, women with eating disorders reported more severe symptoms of separation anxiety during childhood, and scored higher on the ASQ scales, reflecting insecure styles of adult attachment. Early separation anxiety and insecure attachment were not correlated with age of onset or illness duration. The diagnostic subgroup was not associated with a specific style of insecure attachment: compared with control women, both anorexic and bulimic women scored higher on the ASQ scales reflecting anxious attachment, but not on the scales reflecting avoidant attachment.Conclusions. The results confirm the link between eating disorders and insecure attachment that has been found in previous studies, and extend it to childhood symptoms of separation anxiety.
Autobiographical memory specificity and emotional abuse
Authors: Raes Filip , Hermans Dirk , Williams J. Mark G. , Eelen Paul 
Published: March 2005

Objective. Examined the relationship between trauma and memory specificity and the importance in this of level of support received.Method. Fifty‐two female undergraduates completed the Autobiographical Memory Test (AMT; Williams & Broadbent, 1986), assessing memory specificity and the Traumatic Experiences Checklist (TEC; Nijenhuis, Van der Hart, & Vanderlinden, 1999), assessing qualitative aspects of trauma.Results. In low‐specific students, those who reported emotional abuse were less specific in their memory. The scores of students who had not received any support for the abuse showed a trend towards retrieval of less specific memories, as compared with those who had received support.Conclusion. Results provide evidence for an association between trauma (emotional abuse) and reduced memory specificity, and suggest that receiving support following the abuse might protect individuals from developing over‐general memory.
The nature of imagery processes underlying food cravings
Authors: Harvey Kirsty , Kemps Eva , Tiggemann Marika 
Published: March 2005

Objective. The study used a working memory approach to examine the nature of the imagery processes underlying food cravings.Design and method. A sample of 60 dieters and 60 non‐dieters were asked to imagine either a food induction or a holiday induction scenario. Participants then performed 18 trials of either a visual imagery task (loading the visuo‐spatial sketch pad) or auditory imagery task (loading the phonological loop). Food craving was measured before and after the induction scenario, and then after every 6 trials of the imagery task.Results. Craving intensity increased following instructions to imagine the food (but not holiday) induction scenario, especially for dieters. As predicted, the visual imagery task was superior to the auditory imagery task in reducing the level of food craving.Discussion. The results confirmed the imaginal basis of food cravings. Specifically, they demonstrated that the imagery processes involved in food cravings are predominantly visual in nature. Hence concurrent tasks that load the visuospatial sketch pad of working memory can be used to reduce food cravings. The findings have potential application in the treatment of craving episodes in clinical populations.
Complement Factor H as a Marker for Detection of Bladder Cancer
Authors: Cheng Zhu-Zhu , Corey Michael J , Pärepalo Maria , Majno Sandra , Hellwage Jens , Zipfel Peter F , Kinders Robert J , Raitanen Mika , Meri Seppo , Jokiranta T Sakari 
Published: March 2005

AbstractBackground: The BTA TRAK™ and BTA stat™ tests for bladder cancer use monoclonal antibodies (mAbs) X13.2 and X52.1 to detect factor H (FH)-related material in urine. The exact ligands remain unknown.Methods: Western blot analyses of purified FH, recombinant factor H-related protein 1 (FHR-1), and serum and urine samples were used to identify the ligands of X13.2 and X52.1. Recombinant FH constructs were used to identify the target sites of X13.2 and X52.1. To analyze whether natural ligands of FH could compete with its recognition by the capture mAb X52.1, we used surface plasmon resonance analysis. The role of the ligands of X52.1 in the BTA TRAK assay was tested with use of purified proteins and FH-depleted samples.Results: X13.2 bound to domain 3 of FH and FH-like protein 1, whereas X52.1 bound to domain 18 of FH and to FHR-1. Using specific FH depletion from a bladder cancer patient’s urine and purified FH, we demonstrated that FH is the ligand recognized by the BTA TRAK test. By contrast, FHR-1 in urine reduced the FH-dependent test signal.Conclusions: FH is a tumor marker for bladder cancer. To reveal the presence of bladder cancer, the BTA TRAK assay detects FH, whereas FHR-1 is able to partly inhibit this detection. This indicates a special mechanism for a diagnostic immunoassay based on the combined effect of simultaneous positive and negative signals in a single sample.
Collapse and Self-Reconstruction of Mesoscopic Architectures of Supramolecular J Aggregates in Solution: From Strings to Tubular Rods
Authors: Yao Hiroshi , Michaels Chris , Stranick Stephan , Isohashi Takeshi , Kimura Keisaku 
Published: March 2005

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This Letter reports the collapse and subsequent self-reassembly of mesoscopic architectures of supramolecular J aggregates in solution. Ultrasonication of the string-like 5,5-dichloro-3,3-disulfopropyl thiacyanine (TC) J aggregates caused fragmentation (collapse) of the initial morphology, followed by a prompt self-reconstruction into mesoscopic rod-like architectures. Fluorescence microscopy, polarized light microscopy, atomic force microscopy and near-field scanning optical microscopy revealed that the apparent rod-like morphology was a tubular architecture with a monomolecular wall (single-wall) and open ends.
Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations
Authors: Small Aeron M. , Pournamdari Ashley , Melloni Giorgio E.M. , Scirica Benjamin M. , Bhatt Deepak L. , Raz Itamar , Braunwald Eugene , Giugliano Robert P. , Sabatine Marc S. , Peloso Gina M. , Marston Nicholas A. , Natarajan Pradeep 
Published: February 2024

ImportanceElevated lipoprotein(a) (Lp[a]) is a putative causal risk factor for atherosclerotic cardiovascular disease (ASCVD). There are conflicting data as to whether Lp(a) may increase cardiovascular risk only in the presence of concomitant inflammation.ObjectiveTo investigate whether Lp(a) is associated with cardiovascular risk independent of high-sensitivity C-reactive protein (hs-CRP) in both primary and secondary prevention populations.Design, Setting, and ParticipantsThis cohort study uses data from 3 distinct cohorts, 1 population-based cohort and 2 randomized clinical trials. Participants included individuals from the UK Biobank (data from 2006-2010) without prevalent ASCVD, participants in the FOURIER (TIMI 59) trial (data from 2013-2017) who had baseline Lp(a) and hs-CRP data, and participants in the SAVOR-TIMI 53 trial (data from 2010-2013) who had prevalent ASCVD and baseline values for Lp(a) and hs-CRP. The data analysis took place from November 2022 to November 2023.ExposureBaseline plasma Lp(a), considered either as a continuous variable or dichotomized at 125 nmol/L.Main Outcomes and MeasuresRisk of major adverse cardiovascular events (MACE) (composite of cardiovascular death, myocardial infarction [MI], or ischemic stroke), the individual MACE components, and peripheral artery disease (PAD).ResultsAmong 357 220 individuals in the UK Biobank without prevalent ASCVD, 232 699 (65%) had low hs-CRP (&amp;lt;2 mg/L), and 124 521 (35%) had high hs-CRP (≥2 mg/L) values. In a Cox proportional hazard model adjusted for ASCVD risk factors, higher Lp(a) was associated with increased cardiovascular risk regardless of baseline hs-CRP value for MACE (hs-CRP ≥2 mg/L: hazard ratio [HR] per 50-nmol/L higher Lp[a], 1.05; 95% CI, 1.04-1.07; P &amp;lt; .001; for hs-CRP &amp;lt;2 mg/L: HR, 1.05; 95% CI, 1.04-1.07; P &amp;lt; .001; P = .80 for interaction), as well as MI, ischemic stroke, and PAD individually. Among 34 020 individuals in the FOURIER and SAVOR trials with baseline cardiometabolic disease, there were 17 643 (52%) with low and 16 377 (48%) with high baseline hs-CRP values. In Cox proportional hazard models using aggregated data from FOURIER and SAVOR, higher baseline Lp(a) was associated with increased cardiovascular risk regardless of baseline hs-CRP for MACE (hs-CRP ≥2 mg/L: HR per 50-nmol/L higher Lp[a], 1.02; 95% CI, 1.00-1.05; P = .04; hs-CRP &amp;lt;2 mg/L: HR, 1.05; 95% CI, 1.02-1.08; P &amp;lt; .001; P = .16 for interaction), MI, and PAD.Conclusions and RelevanceIn this study, higher levels of Lp(a) were associated with MACE, MI, and PAD in both primary and secondary prevention populations regardless of baseline hs-CRP value.