bluuebunny/crossref_metadata_2025_split huggingface dataset:
PLANO ESTRATÉGICO COMO UM PRODUTO DE INOVAÇÃO E GOVERNANÇA INSTITUCIONAL: A EXPERIÊNCIA DA TRANSIÇÃO/IMPLANTAÇÃO DA UFNT
Authors: Medeiros Ana Lúcia , Abreu Sousa Kleber , Matos Ribeiro Mariana , De Carvalho Silva Andréia 
Published: December 2023

A Universidade Federal do Norte do Tocantins (UFNT) resultou do desmembramento da Universidade Federal do Tocantins (UFT). O processo de transição UFT/UFNT buscou conceder autonomia à nova universidade, demandando a criação de um modelo de governança e gestão. Esse modelo orientou desde a implantação dos grupos de trabalho atuantes nos níveis tático e operacional até a elaboração dos documentos essenciais. Este estudo tem como objetivo analisar a utilização do Planejamento Estratégico Situacional (PES) na elaboração do primeiro Planejamento Estratégico (PE) da UFNT, considerando-o como um produto de inovação decorrente do modelo de governança empregado durante a transição da UFNT. Realizou-se uma pesquisa qualitativa, por meio de estudo de caso e observação participante. A análise de conteúdo foi utilizada para analisar as informações coletadas. A hipótese é que a UFNT aplicou o PES como método na elaboração do PE. Embora as informações coletadas não atribuam explicitamente ao PES como o método aplicado, é possível observar uma forte influência desse método. Este estudo contribui para a compreensão do processo de construção do Planejamento Estratégico em uma instituição pública de ensino superior, destacando a vantagem metodológica do PES, especialmente em contextos acadêmicos complexos e participativos, como a transição e implantação de uma universidade.
The efficacy and safety of pyrotinib in treating HER2-positive metastatic breast cancer patients:A multi-center study
Authors: Gao Min , Li Yuhui , Dong Qingfen , Chen Fang , Fu Chao , Liu Shuaishuai , Liu Shuai , Ju Xiao , Zheng Xin , Lu Jie 
Published: December 2023

Abstract
Purpose: To investigate the efficacy and safety of pyrotinib in treating patients with HER2-positive metastatic breast cancers (MBC).
Patients and Methods: We performed a multi-center retrospective study, and the HER2-positive MBC patients were recruited. The progression-free survival (PFS), and overall survival (OS) were considered in the assessment of treatment outcomes.
Results: 275 female patients were enrolled. The objective response rate (ORR) and disease control rate (DCR) , were found in 154 of 275 (56%) and in 205 of 275 (75%), respectively. The median effective time was 45 days. The median follow-up time was 41 months.The median time for progression and OS were 16 and 35 months. The PFS of survival general population at 1-year, 2-year and 3-year was 72.7% , 40.4%, and 33.1%, respectively, whle the OS was 91.6% , 78.2%, and 63.2%, respectively. The PFS of brain metastases patients at 1-3-year was 67.3%, 25% and 13.5%, while, the OS was 84.6%, 63.5% and 46.2%.
Conclusion: Pyrotinib mono-therapy showed equivalent local control rates, PFS and OS, compared with the combined therapy of pyrotinib and chemotherapy in both the general population and patients with brain metastases, with manageable toxicity, highlighting the significance of mono-therapy of pyrotinib in treating HER-2 positive MBC.
An Inactivated Rabies-based Lassa Fever Virus Vaccine Candidate, LASSARAB, Protects Nonhuman Primates from Lethal Disease
Authors: Schnell Matthias , Scher Gabrielle , Yankowski Catherine , Kurup Drishya , Josleynl Nicole , Wilkinson Eric , Wells Jay , Steffens Jesse , Lynn Ginger , Vantongeren Sean , Zeng Xiankun (Kevin) , Twenhafel Nancy , Cashman Kathleen 
Published: December 2023

Abstract

Lassa fever virus (LASV), a member of the Arenavirus family, is the etiological agent of Lassa fever, a severe hemorrhagic disease that causes considerable morbidity and mortality in the endemic areas of West Africa. LASV is a rodent-borne CDC Tier One biological threat agent and is on the World Health Organization’s (WHO) Priority Pathogen list. Currently, no FDA-licensed vaccines or specific therapeutics are available. Here, we describe the efficacy of a deactivated rabies virus (RABV)-based vaccine encoding the glycoprotein precursor (GPC) of LASV (LASSARAB). Nonhuman primates (NHPs) were administered a two-dose regimen of LASSARAB or an irrelevant RABV-based vaccine to serve as a negative control. NHPs immunized with LASSARAB developed strong humoral responses to LASV-GPC. Upon challenge, NHPs vaccinated with LASSARAB survived to the study endpoint, whereas NHPs in the control group did not. This study demonstrates that LASSARAB is a worthy candidate for continued development.
Prediction and assessment of meteorological drought characteristics in China based on a future climate model
Authors: Huang Tingting , Liu Yu , Jia Zhifeng , Zhang Zengxin , Ma Xiaoyi 
Published: December 2023

Abstract
Under the background of a warm and humid climate, predicting and evaluating the future pattern of wet and dry change characteristics in watersheds is of great research significance. Based on the Geophysical Fluid Dynamics Laboratory earth system coupling model and GFDL‒ESM2M climate model, which is highly applicable in China, the characteristics of standardized precipitation evapotranspiration index (SPEI) variations in China at annual and monthly scales was assessed based on downscaled climate data under four typical representative concentration pathway scenarios. The results are as follows: (1) In the future, the annual scale meteorological drought trend in China will become more "aridity", and the monthly scale dry and wet changes will be non-uniform. With the increase of carbon dioxide emission concentration, the proportion of regional aridity in China will be increased in the future. (2) The proportion of wetting area will decrease, and extreme weather events are more likely to occur. In the future, the drought duration in China will mainly be 1–4 months. (3) The return period of drought in large areas of the country will be 1–50 years, and the return period in some western regions even exceed 500 years.
Promoting the implementation of a computer-tailored physical activity intervention: Development and feasibility testing of an implementation intervention
Authors: Peels Denise A. , Boekhout Janet M. , Nassau Femke Van , Lechner Lilian , Bolman Catherine A.W. , Berendsen Brenda A.J. 
Published: December 2023

Abstract

Background
Although there are many proven effective physical activity (PA) interventions for older adults, implementation in a real world setting is often limited. This study describes the systematic development of a multifaceted implementation intervention targeting the implementation of an evidence-based computer-tailored PA intervention and evaluates its use and feasibility.
Methods
The implementation intervention was developed following the Intervention Mapping (IM) protocol, supplemented with insights from implementation science literature. The implementation intervention targets the municipal healthcare policy advisors, as an important implementation stakeholder in Dutch healthcare system. The feasibility of the implementation intervention was studied among these stakeholders using a pretest-posttest design within 8 municipal healthcare settings. Quantitative questionnaires were used to assess task performance (i.e. achievement of performance objectives), and utilization of implementation strategies (as part of the intervention). Furthermore, changes in implementation determinants were studied by gathering quantitative data before, during and after applying the implementation intervention within a one-year period. Additionally, semi-structured interviews with stakeholders assessed their considerations regarding the feasibility of the implementation intervention.
Results
A multi-faceted implementation intervention was developed in which implementation strategies (e.g. funding, educational materials, meetings, building a coalition) were selected to target the most relevant identified implementation determinants. Most implementation strategies were used as intended. Execution of performance objectives for adoption and implementation was relatively high (75–100%). Maintenance objectives were executed to a lesser degree (13–63%). No positive changes in implementation determinants were found. None of the stakeholders decided to continue implementation of the PA intervention further, mainly due to the unforeseen amount of labour and the disappointing reach of end-users.
Conclusion
The current study highlights the importance of a thorough feasibility study in addition to the use of IM. Although feasibility results may have demonstrated that stakeholders broadly accepted the implementation intervention, implementation determinants did not change favorably, and stakeholders had no plans to continue the PA intervention. Yet, choices made during the development of the implementation intervention (i.e. the operationalization of Implementation Mapping) might not have been optimal. The current study describes important lessons learned when developing an implementation intervention, and provides recommendations for developers of future implementation interventions.
Comparison of short-term complications and long-term prognostic of pancreaticoduodenectomy with and without preoperative biliary drainage in malignant obstructive jaundice
Authors: Qu Guangzhen , Lyu Shao-Cheng , Kou Jiantao , Gao Kun , Lang Ren 
Published: December 2023

Abstract

Background: Malignant obstructive jaundice is a common symptom in patients with periampullary cancer. The impact of PBD on short-term complications after pancreaticoduodenectomy (PD) and the risk factors affecting long-term survival for periampullary cancer still unravel.
Methods: We retrospectively collected relevant data of patients with periampullary cancer who underwent pancreaticoduodenectomy for obstructive jaundice from 2017 to 2022. We divided them into PBD group and Non PBD group based on whether preoperative biliary drainage was performed. The postoperative complications between the PBD group and the Non-PBD group was compared. Binary logistic analysis is used to identify relevant risk factors affecting complications after PD. The differences in the incidence of postoperative complications among different biliary drainage methods and duration of biliary drainage were also analyzed. Afterwards, univariate Cox and multivariate Cox regression analyses were performed to identify risk factors associated with prognosis of pancreatic cancer, common bile duct cancer, and Vater ampullary cancer.
Results: A total of 165 patients were included in the analysis (PBD=84, Non PBD=81). There was no difference in age, gender, BMI, American Society of Anesthesiologists (ASA), and disease history between the PBD group and the Non PBD group. The incidence of postoperative complications in the PBD group was 55%, while in the Non PBD group it was 51%, with no statistical discrepancy (P = 0.10). The positive rate of postoperative drainage fluid culture in the PBD group was slightly higher than that in the Non-PBD group (19% versus 10%, P=0.095). Preoperative total bilirubin>200μmol/L (OR = 32.545, P ＜0.001) and prolonged surgical duration (OR = 1.006, P = 0.008) are independent risk factors for postoperative complications in PD. There was no discrepancy in the postoperative complications between the PBD ≤ 14 day subgroup and the PBD>14 day subgroup (P = 0.5), as well as between PTCD and ERCP drainage methods (P = 0.8). PBD and preoperative total bilirubin do not affect long-term survival after surgery for periampullary cancer.
Conclusions
Preoperative biliary drainage does not affect the incidence of postoperative complications in periampullary cancer with malignant obstructive jaundice, nor does it affect its long-term survival. Preoperative total bilirubin > 200μmol/L is an independent risk factor affecting the occurrence of complications after PD. The positive rate of postoperative drainage fluid bacterial culture in the PBD group is slightly higher than that in the Non-PBD group. Poor tumor differentiation and vein resection are common risk factors for long-term survival of pancreatic cancer and common bile duct cancer after PD.
Relationship between alveolar bone thickness, root apex position, and cephalometric skeletal indexes in the upper anterior teeth of adults with Class Ⅱ malocclusion.
Authors: Zheng Hui , Cui Shuxia 
Published: December 2023

Abstract
Objectives
To measure the alveolar bone thickness and root apex position in the upper anterior teeth of adults with Class Ⅱ malocclusion, and to explore the correlation with the corresponding cephalometric skeletal indexes.
Materials and Methods
Retrospective data collection was done on 90 adult patients with Class Ⅱ malocclusion. Measurement of sagittal skeletal patterns (SNA, SNB, ANB), vertical skeletal patterns (GoGn-SN), labial, lingual and total alveolar bone thickness in the root apex area (Tlabial, Tlingual, Ttotal), the labial, lingual and total rotation range of root (Rlabial, Rlingual, Rtotal), calculating root apex position (Pdistance, Pangle), and conducting correlation research.
Results
Tlabial(1.08 ± 0.96mm) and Rlabial (8.65 ± 7.33°) were significantly smaller then Tlingual(5.07 ± 1.7mm) and Rlingual(35.68 ± 14.82°) (P < 0.01) respectively; Ttotal was 6.15 ± 2.06mm, and Rtotal was 44.33 ± 14.38°; The maxillary central incisor root apex was situated at about 20% of the labial side of the alveolar bone (Pdistance: 19.04 ± 14.58%, Pangle: 21.10 ± 15.64%). Pearson correlation showed that: Ttotal, Rlingual and Rtotal were negatively correlated with GoGn-SN (r=-0.415, P < 0.01; r=-0.358, P < 0.05; r=-0.444, -0.411, P < 0.01); Ttotal, Rlingual and Rtotal were positively correlated with SNB (r = 0.316, P < 0.05; r = 0.421, P < 0.01; r = 0.476, P < 0.01).
Conclusions
In Class Ⅱ malocclusion the root apex is located on the labial side of the alveolar bone, and the thickness of the alveolar bone on the labial side is thin. The labial side of the maxillary incisor and the total alveolar bone thickness should be carefully examined in patients with high mandibular plane angle and mandibular retraction.
Clinical Relevance:
The study shows that it is important to evaluate the alveolar bone thickness and root apex position before orthodontic treatment, and to guide clinical practice from cephalometric measurement.
Lipoprotein(a) is associated with higher DNA damage in patients with heterozygous familial hypercholesterolemia
Authors: Woźniak Ewelina , Broncel Marlena , Woźniak Agnieszka , Satała Joanna , Pawlos Agnieszka , Bukowska Bożena , Gorzelak-Pabiś Paulina 
Published: December 2023

Abstract
Heterozygous familial hypercholesterolemia (HeFH) is a frequent autosomal-dominant inherited disorder associated with premature cardiovascular disease (CVD). HeFH subjects have a higher lipoprotein(a) (Lp(a)) concentration than the general population. Patients with FH are exposed to elevated levels of LDL from birth and ox-LDL may induce other oxidation pathways. The aim of the study was to determine the levels of markers of oxidative stress, and DNA damage in patients with HeFH and describe the effect of Lp(a) on the resulting damage. Higher DNA damage was identified in patients with HeFH compared the normolipidemic and CVD was associated with higher damage (determined by comet assay). Oxidative stress markers are elevated in HeFH patients (determined by comet assay); however, only ox-LDL was higher in the CVD group and its level correlated with DNA damage. Patients with HeFH show a positive correlation between the levels of DNA damage and Lp(a). Higher levels of Lp(a) are associated with greater DNA damage, especially in patients with HeFH and CVD. In HeFH patients, the optimal cut-off point of Lp(a) level associated with CVD is > 25nmol/L, i.e. much lower than for the general population. However this cut-off point needs validation in a larger group of HeFH patients.
Hydraulic fracturing of specimens with holes by using the fluid-solid coupling method based on the continuum-discontinuum method
Authors: Bai Xueyuan , Wang Xuebin 
Published: December 2023

Abstract
Using the self-developed fluid-solid coupling method base on the continuum-discontinuum method (which combined the Lagrangian element method and the discrete element method) considering element splitting, the seepage with single fracture and the hydraulic fracturing of specimens with holes are simulated, and the influence of the size of the hole and the preset fracture on the hydraulic fracturing is studied. It is found that for the unsteady seepage with single fracture, under different conditions, the flow of fluid from one end with the high pressure to the other end with the low pressure, and the numerical results are consistent with the theoretical results. For the disc with a hole, the propagation of fractures is obtained. With the increase of time steps, the maximum principal stress near the surface of the hole increases; then these positions creaking; four main fractures form gradually and their direction are almost radial. The number of tensile fracture segments-time steps curves show two stages: the number of tensile fracture segments is zero and the number of tensile fracture segments increases rapidly. The lager of the hole is, the time corresponding to the propagation of fractures is earlier. For the square specimen with a hole, under the hydrostatic pressure, the maximum principal stress is negative at first; with the increase the fluid pressure, fractures occur near the hole and propagate into the specimen; the farther away from the hole, the lower the fluid pressure is. Compared with the results no preset fracture, the fractures are prone to cracking; the propagation of fractures from the preset fractures first, then the propagation of fractures shows a symmetrical trend for the preset fractures specimens.
Women's preferred childbirth positions and associated factors among postpartum mothers in public hospitals of South West Shoa Zone,Oromia, Ethiopia, cross-sectional study supplemented by qualitative data
Authors: Kebede Tadele , Wakgari Negash , Kolola Tufa , Abdissa Gizachew 
Published: December 2023

Abstract

Background: maternal birth position is the position a mother assumes during childbirth. Freedom to choose birth positions will benefit the woman, baby, and health system. In Ethiopia, women are still giving birth by the lithotomy position, despite of their preference. The issue of birth position is the most neglected one during childbirth in Ethiopia. This study can provide clues for healthcare providers to respect women’s preferred childbirth position, hence, this study was intended to assess the magnitude of women's preferred childbirth positions and associated factors among postpartum mothers in public hospitals of South West Shoa Zone, Oromia, Ethiopia.
Method: Facilities-based cross-sectional study design supplemented by qualitative data was conducted. A systematic random sampling technique was used to select 633 mothers. Data was collected using interviewer-administered structured questionnaires. Bivariables and multivariable logistic regression analysis were done to identify associated factors.
Results: About391 (64.2%) of study participants gave birth by their preferred birth position. Mother age 21-30years (AOR=0.05;95%CI[0.004-0.75]) and 31-40years (AOR=0.02;95%CI[0.002-0.35]), attending school (AOR=3.88;95%CI[1.38-10.93]), Government employee (AOR=2.33;95%CI[1.08-5.01]), a monthly income of 2500-5000ETB(AOR=2.95;95%CI[1.32-6.56]),previous history of home delivery (AOR=1.96;95%CI[1.02-3.80]) and rural residence (AOR=0.43;95%CI[0.23-0.82]) were associated with women's preferred childbirth position. The qualitative finding depicts that health facility and health care providers-related barriers were the main barriers to women's preferred childbirth position in the study area.
Conclusion: women's preferred childbirth position was not respected for more than one-third of study participants. Mother age, educational level, occupation, monthly income, previous place of birth, and residence were associated with women's preferred childbirth positions. Health facility and health care provider’s related barriers were the main barriers to women's preferred childbirth position.
Plastome structure, phylogeny and evolution of plastid genes in Reevesia (Helicteroideae, Malvaceae)
Authors: Geng Li-Yang , Jiang Tian-Yi , Chen Xin , Li Qiang , Ma Jian-Hui , Hou Wen-Xiang , Tang Chen-Qian , Wang Qin , Deng Yun-Fei 
Published: December 2023

Abstract

Reevesia is an eastern Asian-eastern North American disjunction genus in the family Malvaceae s.l. and comprises approximately 25 species. The relationship within the genus is little understood. Here, 15 plastomes representing 12 Reevesia species were compared, with the aim of better understanding the species circumscription and phylogenetic relationships within the genus and among genera in the family Malvaceae s.l. The 11 newly sequenced plastomes range between 161,532 and 161, 945 bp in length. The genomes contain 114 unique genes, and 18 of which are duplicated in the inverted repeats (IRs). Gene content of these plastomes is nearly identical. All the protein-coding genes are under purifying selection in the Reevesia plastomes compared. The top ten hypervariable regions, SSRs, and the long repeats identified are potential molecular markers for future population genetic and phylogenetic studies. Phylogenetic analysis based on the whole plastomes confirmed the monophyly of Reevesia and a close relationship with Durio (traditional Bombacaceae) in subfamily Helicteroideae, but not with the morphologically similar genera Pterospermum and Sterculia (both of traditional Sterculiaceae). Phylogenetic relationships within Reevesia suggested that two species, R. pubescens and R. thyrsoidea, as newly defined, are not monophyletic. Six taxa, R. membranacea, R. xuefengensis, R. botingensis, R. lofouensis, R. longipetiolata and R. pycnantha, are suggested to be recognized.
Relationship between minute ventilation and carbon dioxide production in cardiopulmonary exercise test and ventricular ejection fraction
Authors: Tuta-Quintero Eduardo , Bastidas-Goyes Alirio , Botero Juan D. , Botero-Rosas Daniel , Prieto Daniel , Rubio Daniela , López Cristian , Hincapié Gustavo A. , Mantilla Barbarita , Brito Abraham , Vargas Tatiana , Forero Stefanía , Villarraga Laura , Giraldo Andrea , Briceño Mónica , Porras Alejandra 
Published: December 2023

Abstract
Background
Cardiopulmonary exercise testing is a non-invasive alternative in the evaluation of subjects with heart failure and because it comprehensively evaluates the respiratory and cardiovascular systems under conditions of physical stress. The objective is validity of the values in the ventilatory equivalents in the diagnosis of heart failure with reduced left ventricular ejection fraction.
Methods
Cross-sectional study in subjects with cardiopulmonary exercise testing and transthoracic echocardiography. The participants had a diagnosis of heart failure according to the American Heart Association, a group with reduced left ventricular ejection fraction < 40% and no reduced ≥ 40%, this last group included patients with intermediate or normal ejection fraction.
Results
In the final analysis, 138 patients were included, of whom 88% (122/138) had reduced left ventricular ejection fraction and 12% (16/138) not reduce, mean age was 58.9 years (SD: 16.37), 65% were men, and the body mass index was 27.6 (SD: 4.56). In patients with reduced left ventricular ejection fraction, maximum oxygen consumption presented an average of 1.6 l/min (SD: 0.68) compared to 1.7 l/min (SD: 0.66) in the control group (p = 0.513). The ventilatory equivalents for carbon dioxide (VE/VCO2) during the ventilatory and maximum threshold presented an average of 38.4 (SD: 7.38) and 44.6 (SD: 8.24), respectively. The discriminatory performance of VE/VCO2 versus peak oxygen consumption was 0.737 (95% CI: 0.596–0.878; p = 0.008) in patients with left ventricular ejection fraction < 40%.
Conclusions
VE/VCO2 was a reliable predictor of normal or reduced left ventricular ejection fraction and performs well against peak oxygen consumption.