bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avelumab first-line maintenance therapy for locally advanced/metastatic urothelial carcinoma: Results from the real-world US PATRIOT-II study.
Authors: Grivas Petros , Barata Pedro C. , Moon Helen H. , Gupta Shilpa , Hutson Thomas E. , Sternberg Cora N. , Brown Jason , Dave Vaidehi , Downey Chad , Shillington Alicia C. , Katzenstein Howard , Kirker Melissa , Hanson Sarah , Liu Frank X. , Morris Valerie A. , Bhanegaonkar Abhijeet , Sonpavde Guru P. 
Published: January 2024

697 Background: In the JAVELIN Bladder 100 phase 3 trial, avelumab first-line maintenance (AVE 1LM) + best supportive care (BSC) improved overall survival (OS) and progression-free survival (PFS) vs BSC alone in patients (pts) with locally advanced/metastatic urothelial carcinoma (la/mUC) with no disease progression following 4-6 cycles of platinum-based chemotherapy (PBC). PATRIOT-II aimed to describe real-world outcomes in pts with la/mUC treated with AVE 1LM who were progression-free after 1L PBC. We hypothesized that outcomes would be similar to those of JAVELIN Bladder 100. Methods: PATRIOT-II is an observational, retrospective study in US pts with la/mUC treated in geographically dispersed community and academic centers. Pts receiving AVE 1LM were eligible. Data were collected via medical records for a minimum of 52 weeks (wks) from AVE 1LM initiation. This analysis focuses on ≥24 wks post AVE 1LM initiation. Survival and safety outcomes were assessed; analyses are descriptive in nature. Results: 160 pts from 37 sites, a mix of oncology practices and community/academic centers, were included with median age, 70 (range, 40-90) years; 123 (77%) male; 118 (74%) White, non-Hispanic; 77 (49%) lower tract and 49 (31%) upper tract tumors; 119 (74%) ECOG PS 0/1; 70 (44%) and 51 (32%) known visceral (excluding bone) or non-visceral metastases (mets), respectively; 31 (19%) liver mets; and 64 (40%) creatinine clearance >60 mL/min. 100 (62.5%) and 60 (37.5%) pts had received 1L cisplatin or carboplatin, respectively. 130 pts (objective response rate, 81% [complete response, 21; partial response, 109]) had an investigator-assessed response to 1L PBC. Pts initiated AVE 1LM at a median of 4 wks (IQR, 3-6) after PBC completion. At data cutoff, 120 pts (75%) had discontinued AVE 1LM, 89 (74% of 120) due to progression/adverse events (AEs)/other non-death related reasons. Median time on AVE 1LM was 4.1 months (mo) (IQR, 2.3-8.7); median follow-up time post AVE 1LM initiation was 11.5 mo (IQR, 7.5-16.3). Table shows OS and PFS data. Most common documented treatment-related AEs (any grade) included hypothyroidism (n=7 [4%]), anemia (n=6 [4%]), blood creatinine increased (n=6 [4%]), fatigue (n=6 [4%]), and nausea (n=6 [4%]). Grade 3+ AEs occurred in 19 (12%), with no Grade 5 AEs. No new safety signals were noted. Conclusions: Results complement JAVELIN Bladder 100 and align with other AVE 1LM real-world studies. Limitations include retrospective data, lack of randomization and central scan review, missing data, selection bias, and confounders. PATRIOT-II further supports the level I evidence for AVE 1LM as standard of care in la/mUC not progressing on 1L PBC. [Table: see text]
Azacitidine, Venetoclax, and Gilteritinib in Newly Diagnosed and Relapsed or Refractory FLT3-Mutated AML
Authors: Short Nicholas J. , Daver Naval , Dinardo Courtney D. , Kadia Tapan , Nasr Lewis F. , Macaron Walid , Yilmaz Musa , Borthakur Gautam , Montalban-Bravo Guillermo , Garcia-Manero Guillermo , Issa Ghayas C. , Chien Kelly S. , Jabbour Elias , Nasnas Cedric , Huang Xuelin , Qiao Wei , Matthews Jairo , Stojanik Christopher J. , Patel Keyur P. , Abramova Regina , Thankachan Jennifer , Konopleva Marina , Kantarjian Hagop , Ravandi Farhad 
Published: January 2024

PURPOSE Azacitidine plus venetoclax is a standard of care for patients with newly diagnosed AML who are unfit for intensive chemotherapy. However, FLT3 mutations are a common mechanism of resistance to this regimen. The addition of gilteritinib, an oral FLT3 inhibitor, to azacitidine and venetoclax may improve outcomes in patients with FLT3-mutated AML. METHODS This phase I/II study evaluated azacitidine, venetoclax, and gilteritinib in two cohorts: patients with (1) newly diagnosed FLT3-mutated AML who were unfit for intensive chemotherapy or (2) relapsed/refractory FLT3-mutated AML (ClinicalTrials.gov identifier: NCT04140487 ). The primary end points were the maximum tolerated dose of gilteritinib (phase I) and the combined complete remission (CR)/CR with incomplete hematologic recovery (CRi) rate (phase II). RESULTS Fifty-two patients were enrolled (frontline [n = 30]; relapsed/refractory [n = 22]). The recommended phase II dose was gilteritinib 80 mg once daily in combination with azacitidine and venetoclax. In the frontline cohort, the median age was 71 years and 73% of patients had an FLT3-internal tandem duplication (ITD) mutation. The CR/CRi rate was 96% (CR, 90%; CRi, 6%). Sixty-five percent of evaluable patients achieved FLT3-ITD measurable residual disease <5 × 10–5 within four cycles. With a median follow-up of 19.3 months, the median relapse-free survival (RFS) and overall survival (OS) have not been reached and the 18-month RFS and OS rates are 71% and 72%, respectively. In the relapsed/refractory cohort, the CR/CRi rate was 27%; nine additional patients (41%) achieved a morphologic leukemia–free state. The most common grade 3 or higher nonhematologic adverse events were infection (62%) and febrile neutropenia (38%), which were more frequent in the relapsed/refractory cohort. CONCLUSION The combination of azacitidine, venetoclax, and gilteritinib resulted in high rates of CR/CRi, deep FLT3 molecular responses, and encouraging survival in newly diagnosed FLT3-mutated AML. Myelosuppression was manageable with mitigative dosing strategies.
Red or blue tensor spectrum from GW170817-compatible Einstein-Gauss-Bonnet theory: A detailed analysis
Authors: Oikonomou V. K. , Tsyba Pyotr , Razina Olga 
Published: January 2024

Abstract
In this work we shall prove that the tensor spectral index of the primordial tensor perturbations for GW170817-compatible Einstein-Gauss-Bonnet theories, takes the approximate simplified form

at leading order, with

being a function of the scalar field which depends on the scalar field potential and the second derivative of the scalar-Gauss-Bonnet coupling

. With our analysis we aim to provide a definitive criterion for selecting Einstein-Gauss-Bonnet models that can provide a blue-tilted inflationary phenomenology, by simply looking at the scalar potential and the scalar-Gauss-Bonnet coupling. We shall prove this using two distinct approaches and as we show the tilt of the tensor spectral index is determined by the values of the potential

and of scalar-Gauss-Bonnet coupling at first horizon crossing. Specifically the blue-tilted tensor spectral index can occur when

at first horizon crossing.
Η Αγιότητα στην υπηρεσία της πολιτικής. Οι προπαγανδιστικές συνδηλώσεις της παράστασης του "Βουλγαροκτόνου" Αγίου Δημητρίου
Authors: ΟΙΚΟΝΟΜΟΥ Στυλιανός 
Published: January 2024

St. Demetrius, the patron saint of Thessaloniki through the ages, the myroblytos and miracle-worker, is the subject of an extremely rich iconography. In one scene the martyr is depicted on horseback, spearing or unhorsing Ioannitzes, a prominent Bulgarian king (1197-1207). The specific iconographical type was conceived during the 13th century in the frame of the byzantine counter-narrative against the second Bulgarian state’s founding ideology, in order to present the aforementioned ruler’s sudden death as one of Demetrius’ numerous miracles. The diffusion of this scene served multiple objectives of Michael VIII Palaiologos’ propaganda, given that St. Demetrius was considered as one of his personal patron saints, a policy which was followed and expanded by his son and successor, Andronicus II Palaiologos. This paper’s aims are to interpret the propaganda meaning of the representation of St. Demetrius as ‘Bulgar-Slayer’ and to offer suggestions upon its dating, based on sources, coins, lead seals and wall paintings.
Interrelation of the main hormonal markers in patients with metabolic syndrome
Authors: Prodan A. , Kamyshnyi O. , Dzhyvak V. 
Published: January 2024

Background. The study of the relationships between the main hormonal markers in patients with metabolic syndrome is relevant due to the growing prevalence of this syndrome in the world. The metabolic syndrome is a complex of risk factors, such as obesity, insulin resistance, hypertension and dyslipidaemia, and is known to significantly increase the risk of developing cardiovascular disease and diabetes.
The aim. The aim is to trace the relationship between hormonal markers of metabolic syndrome and assess their impact on its development.
Materials and methods. The study involved 96 participants from the Ukrainian population, comprising 53 cases of obesity and 43 non-obese individuals (controls), with no significant age and sex differences between the groups.
The hormonal markers investigated included Leptin, Ghrelin, Adiponectin, and Resistin. The determination of serum levels was performed using specific ELISA kits, and correlation analyses were conducted to assess the associations between these markers.
Results and discussion. The correlation analysis revealed a statistically significant close negative association between Ghrelin and Leptin levels (ρ = -0.633, p < 0.001). This implies that as Leptin levels decrease, Ghrelin levels tend to increase. The regression analysis demonstrated that 26.7% of the observed variance in Ghrelin levels could be explained by changes in Leptin levels. A strong negative correlation was observed between Adiponectin and Leptin levels (ρ = -0.818, p < 0.001). This indicates that as Leptin levels decrease, Adiponectin levels tend to increase. The regression analysis suggested that 54.8% of the observed variance in Adiponectin levels could be explained by changes in Leptin levels. The correlation analysis indicated a strong positive association between Resistin and Leptin levels (ρ = 0.776, p < 0.001). As Leptin levels increase, Resistin levels also tend to increase. The regression analysis suggested that 47.5% of the observed variance in Resistin levels could be explained by changes in Leptin levels.
Conclusions. The study reveals significant correlations between hormonal markers in metabolic syndrome patients
Improving RGB illuminant estimation exploiting spectral average radiance
Authors: Erba Ilaria , Buzzelli Marco , Thomas Jean-Baptiste , Hardeberg Jon Yngve , Schettini Raimondo 
Published: January 2024

We introduce a method that enhances RGB color constancy accuracy by combining neural network and k-means clustering techniques. Our approach stands out from previous works because we combine multispectral and color information together to estimate illuminants. Furthermore, we investigate the combination of the illuminant estimation in the RGB color and in the spectral domains, as a strategy to provide a refined estimation in the RGB color domain. Our investigation can be divided into three main points: (1) identify the spatial resolution for sampling the input image in terms of RGB color and spectral information that brings the highest performance; (2) determine whether it is more effective to predict the illuminant in the spectral or in the RGB color domain, and finally, (3) assuming that the illuminant is in fact predicted in the spectral domain, investigate if it is better to have a loss function defined in the RGB color or spectral domain. Experimental results are carried out on NUS: a standard dataset of multispectral radiance images with an annotated spectral global illuminant. Among the several considered options, the best results are obtained with a model trained to predict the illuminant in the spectral domain using an RGB color loss function. In terms of comparison with the state of the art, this solution improves the recovery angular error metric by 66% compared to the best tested spectral method, and by 41% compared to the best tested RGB method.
Challenges experienced by induced lactation women in Malaysia: An exploratory qualitative study
Authors: Che Abdul Rahim Norsyamlina , Sulaiman Zaharah , Ismail Tengku Alina Tengku 
Published: January 2024

BackgroundInduction of lactation occurs when breast milk is produced in a human (woman), without going through the process of pregnancy and delivery. Efforts to produce milk by women who had never been pregnant and give birth are not easy. According to the many who have attempted it, it is far more arduous a task than initiating postpartum lactation, but it is possible and worth the effort.Research aimThis study aimed to explore and understand the challenges for women during induced lactation in Malaysia.MethodsThis qualitative study was done in 2017 and utilized in-depth interview among women who induced lactation in five states based on five regions in Malaysia [Central Region (Selangor), Northern Region (Penang), Southern Region (Johor), East Coast Region (Kelantan), Malaysia Borneo (Sabah)]. All interviews were consented, audio-recorded then transcribed verbatim, followed by identification of main themes.ResultsData saturation was achieved after interviewing a total of 23 induced lactation women. Data synthesized using thematic analysis revealed six themes describing the main challenges during the induction process were (1) health condition, (2) work commitment, (3) overexertion, (4) not eligible to take leave, (5) inability to follow the treatment plan, and (6) difficulty attaching the adopted baby to initiate breastfeeding during induced lactation process.ConclusionsThe challenges faced by women during the process of induced lactation were complex and the induced lactation process requires considerable dedication and determination. The findings of this research will help other women and their spouses/partners comprehend the challenges, obstacles, and support that are needed along the induced lactation process. The Government and other stakeholders have roles in more efforts and programs to help these mothers breastfeed their adoptive child and make them feel more accomplished as women and mothers.
Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis
Authors: Azarboo Alireza , Hosseinkhani Shaghayegh , Ghaseminejad-Raeini Amirhossein , Aazami Hossein , Mohammadi Sayed Mohammad , Zeidi Saba , Razi Farideh , Bandarian Fatemeh 
Published: January 2024

Background
Previous research has suggested that the ELMO1 gene may play a role in the development of diabetic kidney disease. Diabetic kidney disease (DKD) is a serious complication of diabetes and the leading cause of chronic kidney disease and end-stage renal disease (ESRD).

Objective and rationale
This study aim was to systematically review and explore the association between ELMO1 gene polymorphisms and diabetic kidney disease. A comprehensive systematic review provides a clear conclusion and high-level evidence for the association between ELMO1 gene and DKD for future application in personalized medicine.

Methods
A comprehensive search of electronic databases, per PRISMA instructions, was conducted in Scopus, EMBASE, Web of Science, and PubMed databases from 1980 to January 2023. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using appropriate models. Subgroup and sensitivity analyses were performed to explore potential sources of heterogeneity and assess the robustness of the findings.

Results
A total of 5794 diabetes patients with DKD, 4886 diabetes patients without DKD, and 2023 healthy controls were included in the 17 studies that made up this systematic review. In the investigation of DM (Diabetes Mellitus) with DKD vs. DM without DKD, the susceptibility for DKD for the EMLO1 rs741301 polymorphism indicated a significant difference under the dominant, homozygote, and recessive genetic models. The susceptibility for DKD for the EMLO1 rs1345365, rs10255208, and rs7782979 polymorphisms demonstrated a significant difference under the allele genetic models in the analysis of DM with DKD vs. DM without DKD groups. There was a considerable increase in DKD risk in the Middle East when the population was stratified by the region.

Conclusion
The findings of the meta-analysis show that there are a significant connection between the EMLO1 rs741301 polymorphism and DKD susceptibility in overall analyses; as well as rs1345365, rs10255208, and rs7782979 polymorphisms; especially in the Middle East region.
Influence of controlled environmental conditions in potential salivary ocular pain biomarkers for enhancing the assessment of ocular pain
Authors: Sobas Eva M. , Amanda Vázquez , Fernández Itziar , Reinoso Roberto , García-Vázquez Carmen , Ortega Enrique , Enríquez-de-Salamanca Amalia 
Published: January 2024

Purpose
We endeavored to identify objective salivary biomarkers for pain, a subjective sensation with a biological basis, using molecules already described related to pain. The study aimed to analyze inter-individual differences and intersession variability in salivary potential ocular pain biomarkers on healthy subjects, in samples obtained under the influence of controlled environmental conditions.

Methods
Thirty-four healthy subjects, 20 male, 14 female, median age 35.44 years (range 30–40) were exposed for 30 minutes under standard environmental conditions (T: 22°C, 50% relative humidity) in the Controlled Environmental Research Laboratory (CE-Lab, Vision R&D, Valladolid Spain) in two separate visits (V1, V2) at least 24 hours apart. Saliva was collected after the exposure in each of the visits, and cortisol, α-amylase (sAA), secretory IgA (sIgA), testosterone, and soluble fraction of TNFα receptor II (sTNFαRII) were analyzed by ELISA. Repeatability of inter-subject inter-session measurements was assayed by intraclass correlation coefficient (ICC).

Results
There were no significant inter-session differences in testosterone (p = 0.2497), sTNFαRII (p = 0.6451) and sIgA (p = 0.9689) salivary levels. The reproducibility for salivary cortisol, sAA, testosterone, sTNFαRII and sIgA were 0.98 ng/ml, 20.58 U/ml, 21.07 μg/ml, 24.68 pg/ml and 0.19 pg/ml, respectively. Salivary cortisol, sAA, testosterone, sTNFαRII and sIgA yielded the following ICCs: 0.506, 0.569, 0.824, 0.870 and 0.4295, respectively; all these ICCs (except that for cortisol and sIgA) were found to be improved compared to those found previously by our group in a previous study in salivary samples obtained from healthy subjects under non-controlled environmental conditions; Cortisol´s ICC didn´t improve and was in both cases at the limit of acceptability.

Conclusion
Environmental factors such as temperature and relative humidity affect the reproducibility of measurement of some salivary molecules which have been proposed as potential pain biomarkers. The exposure of subjects to standard controlled environmental conditions before salivary sample obtention would improve the reproducibility of these molecule measures’ as potential biomarkers of chronic ocular pain.
Lipid metabolism and functional somatic disorders in the general population. The DanFunD study
Authors: Jørgensen Torben , Jacobsen Rikke Kart , Sæbye Ditte , Petersen Marie Weinreich , Fink Per , Gormsen Lise , Linneberg Allan , Bjerregaard Anne Ahrendt , Schovsbo Signe Ulfbeck , Benros Michael Eriksen , Eplov Lene Falgaard , Jørgensen Niklas Rye , Dantoft Thomas Meinertz 
Published: January 2024

Objectives
Earlier studies on the association between plasma lipid profiles and functional somatic disorders (FSD) are mainly small case control studies hampered by selection bias and do not consider the great overlap between the various FSDs. The aim of the present study was to investigate the associations between various FSDs and plasma lipid profiles (total cholesterol, HDL cholesterol, non-HDL cholesterol and triglycerides) in a large, unselected population.

Design
A cross-sectional general population-based study

Setting
The Danish Study of Functional Somatic Disorders (DanFunD) conducted in 2011–2015 in 10 municipalities in the western part of greater Copenhagen, Denmark.

Participants
A total of 8,608 men and women aged 18–76 years were included in the analyses. Various delimitations of FSD such as chronic fatigue, chronic widespread pain, irritable bowel, and bodily distress syndrome were measured using validated self-administrated questionnaires. Lipid parameters were measured from fasting plasma samples using colorimetric slide methods with Vitros 4600/5600 Ortho Clinical Diagnostics.

Outcome measures
Logistic regression analyses were used to calculate possible associations between plasma lipids and the various delimitations of FSD. Associations are presented by OR (95% CI) and shown in boxplots.

Results
We found a positive association between bodily distress syndrome and triglycerides and non-HDL cholesterol and a negative association with HDL-cholesterol, but no consistent association with total cholesterol. A similar pattern was observed for persons with chronic fatigue, and to some degree for persons with chronic widespread pain, whereas persons with irritable bowel did not show a clear association with the lipid profiles.

Conclusion
This is the first major study on plasma lipid profiles and FSD indicating an association between some delimitations of FSD and an unfavorable lipid profile. Due to the cross-sectional design, it cannot be determined whether the findings are consequences or determinants of FSD. Further studies–preferable prospective studies—are needed.
Association between breastfeeding cessation among under six-month-old infants and postpartum depressive symptoms in Nevada
Authors: Neupane Smriti , de Oliveira Clariana Vitória Ramos , Palombo Cláudia Nery Teixeira , Buccini Gabriela 
Published: January 2024

Background
Postpartum depression affects 13% of women after childbirth in the United States. Mothers who experience depression are less likely to breastfeed than those who do not experience depression. On the other hand, breastfeeding may have a positive effect on maternal mental health.

Research aim
We aimed to analyze whether breastfeeding cessation is associated with postpartum depression symptoms among mothers of infants under six months old in Clark County, Nevada.

Method
A cross-sectional study was conducted in 2021 using a purposive sample of 305 mother-infant dyads. Postpartum depression symptoms were assessed using the Patient Health Questionnaire-2 (PHQ-2), and the breastfeeding cessation was determined through a 24-hour dietary recall. Descriptive, bivariate, and multivariate logistic regression analyses were conducted.

Results
Most participants were between 25 and 34 years old (n = 183, 60.0%), multiparous (n = 167, 55.1%), and had a vaginal delivery (n = 204, 70.6%). High frequency of postpartum depressive symptoms was found among mothers who were young (18–24 years) (24.2%), without a partner (25.0%), had unplanned pregnancies (12.7%), and were primiparous (13.2%). Breastfeeding cessation was independently associated with postpartum depressive symptoms (AOR = 3.30, 95% CI: 1.16–9.32) after controlling for sociodemographic, environmental, and obstetric characteristics.

Conclusion
Breastfeeding cessation is strongly associated with postpartum depressive symptoms among mother-infant dyads in Nevada. Early identification of postpartum depressive symptoms and the promotion of breastfeeding can create a positive feedback loop to foster the well-being of mothers and infants.