bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Nanoparticulate Cosmeceuticals: Boon for Hyperpigmentation
Authors: Pingale Prashant L. , Patil Rupali A. , Bedse Anjali P. , Raut Shilpa S. 
Published: October 2023

Abstract:
Recently nanotechnology has emerged with more attention to the cosmetic industry.
Formulations for skin whitening are widely applied but hyperpigmentation treatment remains
unnoticed. This review summarises use of nanotechnology in hyperpimentaion. Various organic
and inorganic nanoparticles used in cosmeceuticals are explained. Various approaches for treatment of hyperpigmentation, barriers for Nanodelivery, availability of organic and inorganic synthetic nanoparticles are stated in the study. The advantages and disadvantages of these organic
and inorganic compounds are enlisted. Special emphasis has been given to natural substances
including arbutin, Aloesin, hesperidin, niacinamide, liquorice, mulberry, polyphenols, ginseng,
gingko which are used used in hyperpigmentation. Regulatory challenges and issues for clinical
translation, Patents and publications available in last 20 years related to nanotechnology in hyperpigmentation are discussed in brief. It has been observed that amongst nanocosmeceuticals
used for hyperpigmentation, lipid nanoparticles are most widely used due to more skin permeability, biocompatibility, and biodegradable nature. Nonetheless, investigation on health effects
and safety profile of nanomaterials are essential for understanding the impact of using these materials.
Isolation and potency of Actinomycetes from rhizosphere of nutmeg (Myristica fragrans Houtt)
Authors: Mahulette Ferymon , Utarti Esti , Kurnia Tri Santi 
Published: October 2023

Nutmeg (Myristica fragrans Houtt) is commonly cultivated by people in the forests of Moluccas Islands. This plant grows well on relatively infertile soil types. This is presumably due to the presence of symbiotic microbes in the root of nutmeg. The research aimed to isolate, characterize and test the potential of Actinomycetes from rhizosphere of nutmeg. Soil sample were taken from the nutmeg forest in Ambon Island. The Actinomycetes isolation using humic acid vitamin, continued with yeast malt agar (YMA) media. The testing of antibacterial and antifungal activities using YMA media, while cellulolytic activity, phosphate solubilizing, and xylanolytic activity using carboxyl methyl cellulose, Picovskaya agar, and birchwood agar or oat spelt xylan agar. A total of 12 isolates of Actinomycetes were isolated and dominated by Streptomyces with various types of aerial mycelia. The substrate mycelium looks brown and cream, while the aerial mycelium looks white and gray. These isolates had the highest inhibitory power against Escherichia coli and Fusarium oxysporum with indexes of 16.5 mm and 16.0 mm, respectively. The other isolates have the ability of cellulolytic, phosphate solubilizing, and xylanolytic with indexes 3.26, 3.87, and 1.2, respectively. The Actinomycetes isolates that were found can be used as starter to improve the biofertilizer formula for nutmeg.
Bioactive peptides: a review
Authors: Besharati Maghsoud , Lackner Maximilian 
Published: October 2023

Abstract
Bioactive peptides are protein components which are inactive within the protein structure, and upon release by enzymatic hydrolysis, they exhibit special physiological functions. In the last years, the characteristics of bioactive peptides obtained from various plant, animal and microbial sources have received much attention. Bioactive peptides are produced using hydrolysis by enzymes extracted from plants or microorganisms, or digestive enzymes and fermentation by proteolytic starter cultures. The composition and sequence of the amino acids determines their different functions, including relaxing effects, solute binding properties, strengthening of the immune system, antioxidant, anti-microbial, anti-inflammatory, cholesterol-lowering and anti-hypertensive effects. Bioactive peptides are identified by different methods including membrane separation techniques and chromatography from protein hydrolysis products and using spectrometric techniques. The possibility of using bioactive peptides as health or therapeutic components depends on ensuring their bio stability, bioavailability and safety.
Comparative Thermal Behaviour Study of Thermal Layers Made Out of Woven and Nonwoven Fabric Using FR Viscose and p-Aramid Fibres
Authors: Chauhan Shweta , Parmar M S , Sisodia Nidhi 
Published: October 2023

Abstract
Nine 1/1 plain weave fabric samples were developed using various combinations of low-twist ring spun yarns and rovings of FR viscose, p-aramid, and their blends. The three woven combinations were yarn/yarn, yarn/roving, and roving/roving. These fabric samples were compared for mechanical and thermal properties with needle-punched non-woven fabric samples. The radiant heat transfer index (RHTI24) and convective heat transfer index (HTI24) of the woven and non-woven fabrics were determined. In all samples, the HTI24 - HTI12 and RHTI24 - RHTI12 values were more than 4 seconds, which suggested that there was enough time between experiencing pain and sustaining second-degree burns.
From Kuwait to Ukraine: Conflict’s Implications on the Natural Environment and the Responses of International Humanitarian Law
Authors: Wirthová Lucia 
Published: October 2023

Summary
The natural environment has long been the silent casualty of war according to the Guidelines on the Protection of the Natural Environment in Armed Conflict issued by the International Committee of the Red Cross (ICRC). As presented by the ICRC, International Humanitarian Law (IHL) does not reflect the reality of warfare today. Hence, this article builds on the ICRC recommendations with the aim of underlining changes that are essential for protecting the environment during war. Drawing on the experiences from the past and applying them to the current conflict in Ukraine, I propose four broader categories of change. First and foremost, the consensus within the international community is viewed as the basis for any further developments. Thus far politicization has prevented agreement, yet the events since February 24th, 2022, show that there are lessons to be learned. Compromise on the standards and implementation is thus called for, particularly when it comes to the conditions severe, long-term, and widespread damage. From this point of view, international condemnation of environmentally harmful practices in warfare is limited by the conditions’ disproportionately broad scope which arguably needs to be narrowed. Secondly, I suggest that mainstreaming environmental protection during armed conflict is of great importance. Such mainstreaming might be most relevant among military personnel during non-international armed conflicts because of the individualistic approach of national military manuals. Nonetheless, mainstreaming could prove appropriate in international armed conflicts as well, given the limited number of rules relating to the environment in international customary and treaty law. Thirdly, the interconnectedness between energy and environment, and the dangers associated with the destruction of energy infrastructure must be made very clear. Bombings or destabilization of nuclear power plants might be even more catastrophic than the burning and spills of oil wells. The last point of this brief is the need for greater accountability for environmental destruction incurred during armed conflict, especially from a systematic point of view. From this standpoint, the past events such as the establishment of the United Nations Compensation Committee for Kuwait, which inter alia addressed the environmental impacts of the conflict, or the ICC decision to focus more on environmental issues could provide inspiration in relation to Ukraine. Besides, the situation in Ukraine could become a potential landmark case. Consequently, the aim of the four propositions presented here is to define the most pressing limitations of IHL related to the natural environment, and to outline potential recommendations for policy makers who address the crisis in Ukraine as well as any further conflicts to come.
Discovering the factors driving regional competitiveness in the face of climate change
Authors: Karman Agnieszka , Miszczuk Andrzej , Bronisz Urszula 
Published: October 2023

Abstract
This paper identifies the most influential factors in shaping the climate change competitiveness of the EU regions. We conducted multiple linear regression, geographically weighted regression and polynomial best subset regression analysis to explore the variability in regional competitiveness by economic, environmental, social, innovative and technological factors. The results of the study provide rigorously tested and evidence-based insights into the most instrumental factors shaping climate change competitiveness of the EU regions. The findings revealed that the most affected factors were the number of cooling and heating days, CO emissions, e-banking, digital skills, urbanisation levels and access to technology. On the contrary, the levels of migration and of international scientific publications turned out to be minor. The authors believe that this article highlights several interesting findings and new incentives for further research and discussion regarding regional competitiveness in the face of climate change.
Características da atuação publicitária e o uso de social media analytics: cenário do sul do Brasil
Authors: Spagnol Simi dos Santos Silvia , Carvalho Carlos Eduarto 
Published: October 2023

Objetivo – Com o avanço do uso das mídias sociais pelos consumidores e pelas marcas, a análise dos dados advindos de tais meios parece ter se tornado imprescindível para as agências publicitárias atingirem um bom desempenho em suas campanhas. Esta pesquisa explora as características do publicitário atuante no sul do Brasil bem como o cenário das agências de propaganda frente ao uso dos dados de Social Media Analytics (SMA).
Theoretical framework – Utilizou-se as características do publicitário, das agências publicitárias e do uso de análise de mídia social.

Metodologia – Trata-se de um estudo quantitativo e descritivo, operacionalizado por coleta de dados primários por meio de uma survey online a aplicada a 92 profissionais publicitários atuantes em diferentes agências sul brasileiras. Procedeu-se com análise descritiva e de variância (ANOVA) utilizando o software SPSS®.
Resultados – Os resultados mostram o perfil do publicitário e das agências bem como indicam um forte uso de ferramentas de análise convencionais. As agências carecem de pessoas, pesquisa e investimento quanto a coleta de dados em plataformas e softwares complexos como de coleta de dados de big data.
Implicações – Com base nos achados estabelecidos, os futuros pesquisadores podem desejar investigar outras ferramentas a fim de atualizar o campo. Implicações práticas convergem para um maior investimento por parte dos gerentes de mídia social em ferramentas e aprendizado de big data, já que seu uso pode impactar de forma significativa na atuação do profissional no ambiente digital.
Originalidade/Valor – Poucos estudos investigaram os publicitários e agências brasileiras. As descobertas podem ser vistas como um passo preliminar para uma maior compreensão das atividades relacionadas ao fazer publicitário, especialmente frente ao ambiente digital. O estudo também é original pois testou uma escala de uso de ferramentas de SMA, o que fortalece o campo e amplia os conhecimentos específicos inerentes a atividade publicitária no ambiente digital.
Analysis of avian influenza A (H3N8) viruses in poultry and their zoonotic potential, China, September 2021 to May 2022
Authors: Cui Pengfei , Shi Jianzhong , Yan Cheng , Wang Congcong , Zhang Yuancheng , Zhang Yaping , Xing Xin , Chen Yuan , Zhang Jie , Liu Liling , Zeng Xianying , Tian Guobin , Li Chengjun , Suzuki Yasuo , Deng Guohua , Chen Hualan 
Published: October 2023

Background
Two human cases of avian influenza A (H3N8) virus infection were reported in China in 2022.

Aim
To characterise H3N8 viruses circulating in China in September 2021−May 2022.

Methods
We sampled poultry and poultry-related environments in 25 Chinese provinces. After isolating H3N8 viruses, whole genome sequences were obtained for molecular and phylogenetic analyses. The specificity of H3N8 viruses towards human or avian receptors was assessed in vitro. Their ability to replicate in chicken and mice, and to transmit between guinea pigs was also investigated.

Results
In total, 98 H3N8 avian influenza virus isolates were retrieved from 38,639 samples; genetic analysis of 31 representative isolates revealed 17 genotypes. Viruses belonging to 10 of these genotypes had six internal genes originating from influenza A (H9N2) viruses. These reassorted viruses could be found in live poultry markets and comprised the strains responsible for the two human infections. A subset of nine H3N8 viruses (including six reassorted) that replicated efficiently in mice bound to both avian-type and human-type receptors in vitro. Three reassorted viruses were shed by chickens for up to 9 days, replicating efficiently in their upper respiratory tract. Five reassorted viruses tested on guinea pigs were transmissible among these by respiratory droplets.

Conclusion
Avian H3N8 viruses with H9N2 virus internal genes, causing two human infections, occurred in live poultry markets in China. The low pathogenicity of H3N8 viruses in poultry allows their continuous circulation with potential for reassortment. Careful monitoring of spill-over infections in humans is important to strengthen early-warning systems and maintain influenza pandemic preparedness.
Water fleas of Lviv region (Crustacea: Cladocera) in hydrobiological research by B. Dybovsky and M. Grohovsky (based on the materials of the round table of the ecological commission of the Shevchenko Scientific Society)
Authors:   Ivan Franko National University of Lviv, Ivanets O. 
Published: October 2023

49 taxa of Cladocera were registered in the reservoirs of Lviv region according to the materials of B. Dybovskyi and M. Grohovskyi. From the point of view of faunal diversity, the studied locations can be divided into two groups. The first group of locations (registered 10 or more taxa each): Pelchynsky pond, Yanivsky pond, Big Golosko. The second group of locations (up to 5 taxa are registered): Kilinsky Park, Sobka pond, Small Golosko, Zboishcha, Snopkiv, Horodok, Zhydachiv. The largest number of Cladocera taxa was registered in the Janivsky pond (21 taxa). The smallest number (1 taxon) was registered in the location Zboyishcha. Taking into account the frequency of occurrence, 4 groups of taxa were distinguished. The first group has a frequency of 10 % (34 taxa), the second – 21 % (10 taxa), the third – 30 % (4 taxa), the fourth – 50 % (1 taxa). The most common taxa with a frequency of 30 % include Alona affinis, Leydig., Ceriodaphnia polonica, nob., Peracantha truncata, O. Fr. Müll., Sida crystallina, O. Fr. Müll. The frequency of occurrence of 50 % is characteristic of Simocephalus vetulus, O. F. Müll. The measure of pairwise similarity of the Cladocera fauna of reservoirs of various locations, calculated by the Jaccard index and the Sørensen index, has the same trends. 23 pairs of water bodies do not have common species. For them, the Jaccard index and the Sørensen index are equal to zero. The highest coefficient of similarity of fauna between the reservoirs of the locations Kilinsky Park and Zboiyshche (Jaccard’s index – 33 %, Sørensen’s index – 50 %). The lowest rate was registered for the locations Yaniv – Zhidachiv and Small Golosko – Yaniv (Jaccard’s index – 4 %, Sørensen’s index – 8 %). The Jaccard index is characterized by a larger amplitude of the calculated indicators and gives better differentiation at high and average indicators of similarity. With low indicators of similarity, the Sørensen index is preferred. The conducted research is of particular interest in view of the faunal analysis of Cladocera groups and the comparative characteristics of indicators identifying long periods of time. Such materials are one of the key aspects on which the issue of hydroecological monitoring is based.
Prevention of disorders in the mucous membrane of the digestive tract of female rats with estrogen, protein and calcium deficiency
Authors:   Odesa I. I. Mechnykov National University, Sidletskyi O. , Makarenko O. ,   State institution “Institute of Stomatology and Maxillo-Facial Surgery” NAMS of Ukraine
Published: October 2023

Purpose. Substantiation of the preventive efficacy of a complex consisting of quercetin, calcium citrate, vitamins, macro- and microelements in relation to the biochemical parameters of the mucous membranes of the digestive tract of rats with oophorectomy and insufficient protein and calcium in the diet. Materials and methods. The study was conducted on 24 female rats of herd breeding: in 16 animals, the state of estrogen deficiency was modeled by ovariectomy followed by their maintenance on an inadequate diet, half of which were injected with a prophylactic complex of vitamins and minerals. After 4 months, the rats were taken out of the experiment. In the homogenates of the mucous membranes of the oral cavity, stomach, small and large intestine, markers of inflammation (activity of elastase, acid phosphatase and the content of malonic dialdehyde) and the index of bacterial contamination (activity of urease) were determined. Results. As a result of the study, the development of inflammation was established in the mucous membranes of the digestive tract of rats with hypoestrogenism and when receiving a diet deficient in protein and calcium. The development of inflammation was accompanied by an increase in the activity of acid phosphatase (in the oral cavity – by 16.5 %, in the stomach – by 23.3 %, in the small intestine – by 27.0 %, in the large intestine – by 29.6 %), elastase ( in the oral cavity – by 9.2 %, in the stomach – by 52.6 %, in the small intestine – by 93.6 %, in the large intestine – by 28.7 % and the content of malondialdehyde (in the oral cavity – by 25.8 %, in the stomach – by 40.7 %, in the small and large intestine – by 26.4 %, in the large intestine – by 35.7 %) relative to the control group. In addition, an increase in urease activity was registered in the mucous membranes of the digestive tract of rats with pathology, which means an increase in the contamination of opportunistic microorganisms on the mucous membranes. The introduction of the prophylactic complex to rats prevented an increase in inflammation and dysbiosis in the mucous membranes of the digestive tract of animals, which was caused by pathology modeling. Findings. Anti-inflammatory and anti-dysbiotic properties of the prophylactic complex of vitamins and minerals based on quercetin and calcium citrate from Black Sea oyster shells allow us to recommend this composition of preparations for a deeper study in order to create an alternative to hormone replacement therapy for hypoestrogenism with alimentary deficiency of protein and calcium.
Halal Market for Food Productions
Authors: MAHDI Yousef , DJAKELI Kakhaber 
Published: October 2023

This article examines how Georgian products can join the Halal country’s markets and why this market has grabbed attention of many companies from all over the world. The paper discusses the culture and rules of the Muslim market and how to enter to this market. This research focuses on Georgian food products and how to extend them to the Muslims market with their strength and opportunity whichcan be acceptable by this market. The aim of this article is to help those Georgian manufacturers and companies who want to export their products and develop their business, market and their brands and integrate them in the single biggest market in the world that has been largely overlooked.
Occurrence and characterization of plasmids carrying tmexCD1-toprJ1, blaDHA-1, and blaCTX-M-127, in clinical Klebsiella pneumoniae strains
Authors: Qu Ying , Wang Wenji , Lu Qinhong , Qiu Jihai , Wang Dongguo , Ma Liman 
Published: October 2023

ObjectiveToday, the emergence of Klebsiella pneumoniae with the tmexCD1-toprJ1 gene cassette in patients has presented a significant clinical challenge.MethodsTo present the detailed genetic features of the tmexCD1-toprJ1 gene cassette of K. pneumoniae strain F4_plasmid pA, the whole bacterial genome was sequenced by Illumina and nanopore platforms, and mobile genetic elements related to antibiotic resistance genes were analyzed with a series of bioinformatics methods.ResultsK. pneumoniae strain F4 was determined to be a class A+C beta-lactamase, and was resistant to routinely used antibiotics, especially tigecycline, because of the oqxAB gene localized on the F4_chromosome and tmexCD1-toprJ1 on F4_plasmid A. After plasmid transfer assays, the F4_plasmid pA or F4_plasmid pB could be recovered with an average conjugation frequencies of 3.42×10-4 or 4.19×10-4. F4_plasmid pA carried tmexCD1-toprJ1 and blaDHA-1 accompanied by genetic intermixing of TnAs1, Tn5393, TnAs3, and In641, while F4_plasmid pB, bearing blaCTX-M-174, had structural overlap of TnAs3 and In641. ConclusionsWe suggested that plasmids carrying tmexCD1- toprJ1 might be strongly related to IS26-integrated loop intermediates. This study showed that due to the structural evolution of F4 and related strains, their resistances were so strong that effective antibiotics were virtually unavailable, therefore their spread and prevalence should be strictly controlled.
Analysis of the gut microbiota in children with gastroesophageal reflux disease using metagenomics and metabolomics
Authors: Ye Xiaolin , Yu Feihong , Zhou Jin , Zhao Chunna , Wu Jie , Ni Xin 
Published: October 2023

BackgroundThere is no direct evidence of gut microbiota disturbance in children with gastroesophageal reflux disease (GERD). This study aimed to provide direct evidence and a comprehensive understanding of gut microbiota disturbance in children with GERD through combined metagenomic and metabolomic analysis.Methods30 children with GERD and 30 healthy controls (HCs) were continuously enrolled, and the demographic and clinical characteristics of the subjects were collected. First, 16S rRNA sequencing was used to evaluate differences in the gut microbiota between children with GERD and HC group, and 10 children with GERD and 10 children in the HC group were selected for metagenomic analysis. Nontargeted metabolomic analysis was performed using liquid chromatography/mass spectrometry (LC/MS), and metagenomic and metabolomic data were analyzed together.ResultsThere were significant differences in the gut microbiota diversity and composition between children with GERD and HCs. The dominant bacteria in children with GERD were Proteobacteria and Bacteroidota. At the species level, the top three core bacterial groups were Bacteroides stercoris, Bacteroides vulgatus and Alistipes putredinis. The main differential pathways were identified to be related to energy, amino acid, vitamin, carbohydrate and lipid metabolism. LC/MS detected 288 different metabolites in the positive and negative ion modes between children with GERD and HCs, which were mainly involved in arachidonic acid (AA), tyrosine, glutathione and caffeine metabolism.ConclusionThis study provides new evidence of the pathogenesis of GERD. There are significant differences in the gut microbiota, metabolites and metabolic pathways between HCs and children with GERD, and the differences in metabolites are related to specific changes in bacterial abundance. In the future, GERD may be treated by targeting specific bacteria related to AA metabolism.