bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy, safety, and patient satisfaction with oral semaglutide: first single-centre clinical experience
Authors: Janić Miodrag , Jovanović Marija , Janež Andrej , Lunder Mojca 
Published: November 2023

Objective To explore the effects of oral semaglutide on glycaemic parameters, body weight, and satisfaction in the first recipient patients with type 2 diabetes mellitus in Slovenia, in a real-world clinical practice setting. Methods The first consecutive adult patients with type 2 diabetes who were eligible for oral semaglutide treatment were included in this prospective, open-label interventional study. Patients received increasing doses of oral semaglutide and were evaluated at inclusion, at 1 month, then 3–5 months after starting treatment. Fasting blood glucose, glycosylated haemoglobin (HbA1c), body weight, patient satisfaction with oral semaglutide treatment (using the validated Treatment Satisfaction Questionnaire for Medication), and adverse effects, were analysed. Statistical analyses were performed using one-way analysis of variance, and, when significant interactions were found, Bonferroni post-hoc test. A P-value <0.05 was considered statistically significant. Results Twenty patients (11 male: 9 female; mean age, 59.9 ± 1.5 years; mean diabetes duration, 8.5 ± 1.4 years) were included. Oral semaglutide (7 and 14 mg) significantly decreased HbA1c (from 9.4 ± 0.3% to 8.2 ± 0.2% and 7.8 ± 0.2%, respectively) and fasting plasma glucose (from 11.2 ± 0.5 mmol/L to 9.2 ± 0.7 mmol/L and 8.9 ± 0.4 mmol/L, respectively). Oral semaglutide (14 mg) significantly decreased body weight (from 100.9 ± 2.7 kg to 92.7 ± 2.4 kg). Patients reported that treatment was easy to use and expressed high global satisfaction. Mild and transient, mostly gastrointestinal, adverse effects were reported in 10 patients. Conclusions Oral semaglutide, the first oral glucagon-like peptide 1 receptor agonist, was effective and safe, and associated with high patient satisfaction, in its first recipients in Slovenia. The results are important for daily clinical practice involving patients with type 2 diabetes, however, due to the small study population, lack of placebo control, and short exposure to oral semaglutide, the effectiveness of oral semaglutide in clinical practice requires further investigation.
Experiences of Providers and Immigrants/Refugees with Health Care: A Meta-Synthesis of the Latin American Context
Authors: Barreto Mayckel da Silva , Wolf Isadora , Souza Nathalie Campana de , Buzzerio Lorena Franco , Vieira Viviane Cazetta de Lima , Figueiredo-Barbieri Maria do Céu , Marcon Sonia Silva 
Published: November 2023

IntroductionThe experiences of providers and immigrants/refugees related to healthcare in the Latin American context have not yet been aggregated. This study aimed to synthesize the qualitative evidence on this theme.MethodA systematic review of qualitative evidence with meta-synthesis. After identification, eligible studies were evaluated for methodological quality, and information was systematically analyzed.ResultsThe sample comprised 26 articles. The meta-theme shows that the experiences of providers and immigrants/refugees are determined by multilevel factors. In a macro-context, these factors involve the vulnerabilities of immigrants/refugees and the healthcare system/model, and in a closer context, they involve the lack of professional training in cultural skills and communication; language barriers; and prejudice/xenophobia. Within healthcare, the relationship is mostly conflictual, asymmetric, and unable to solve problems, leading to negative repercussions for both.ConclusionsManagers involved in developing public policies and providers must consider improving the interrelationship between healthcare services and the migrant population.
A Study on Effect of Sleep Training Program in Children with ADHD: A Comparative Prospective Study
Authors: Shah Henal , Dani Allauki 
Published: November 2023

Objective: To study complementary effect of sleep training program in children with attention deficit hyperactivity disorder (ADHD) receiving tablet methylphenidate with respect to sleep, quality of life (social, behavioral, emotional, and executive functioning of children), and their parent’s emotional state. Methods and Materials: It was a comparative and prospective study, and it was conducted in child mental health services of a tertiary care municipal hospital. The children (age 8−12 years) were diagnosed with ADHD using DSM 5 criteria. The children’s sleep habit questionnaire (CSHQ) and Kiddie-SADS-PL questionnaire (K-SADS-PL) were used to select 100 consecutive participants (parent–child dyad). They were randomly equally divided into two groups: A and B. Semi-structured proforma was filled and different scales were applied for children; these scales include Strengths and Difficulties Questionnaire (SDQ), Pediatric Quality of Life Inventory (PQLI), Stroop test (ST) and Verbal fluency test (VFT), and to parent-Depression Anxiety Stress Scale-21 (DASS-21). The participants in group A received a validated sleep intervention and the scales were reapplied after 12 weeks. We used Chi-square test, paired t-test, unpaired t-test, Wilcoxon signed-rank test, Mann-Whitney U test, Spearman’s correlation test, and logistic regression analysis for data analysis. p-Value <.05 was taken as significant. SPSS version 20 software was used for data analysis. Results: We found significant post-intervention improvement in sleep, quality of life, social, emotional, behavioral, and executive functioning in children and emotional factors in parents. Conclusion: The combination of sleep intervention and tablet methylphenidate were more effective in improving these factors.
Insecticidal and Repellent Activities of Four Essential Oils Against Sitophilus zeamais (Coleoptera: Curculionidae)
Authors: Fouad Hany Ahmed , da Câmara Cláudio Augusto Gomes , de Moraes Marcílio Martins , Tavares Wagner de Souza , Legaspi Jesusa Crisostomo , Zanuncio José Cola 
Published: November 2023

Objective This study aimed to evaluate the efficacy of Corymbia citriodora, Melaleuca alternifolia (Myrtaceae), Mentha × piperita (Lamiaceae), and Schinus terebinthifolius (Anacardiaceae) essential oils as an alternative to manage Sitophilus zeamais (Coleoptera: Curculionidae) adults. Methods Acute contact toxicity, acute toxicity on treated maize grain, fumigation toxicity, repellency bioassays, and GC-MS analysis of the essential oils were carried out. Results Corymbia citriodora, M. alternifolia, M. × piperita, and S. terebinthifolius oils were toxic at different levels to S. zeamais through residual contact, ingestion and via fumigation, and were also repellent to adults of this pest. Melaleuca alternifolia oil was the most active in contact (LC50 = 18.98 μL.mL−1), ingestion (LC50 = 1.03 μL.g−1), and fumigant (LC50 = 20.05 μL.L−1 air) bioassays. Citronelal (53.6% in C. citriodora), terpinen-4-ol (46.9% in M. alternifolia), menthol (44.8% in M. × piperita), and β-caryophyllene (16.2% in S terebinthifolius) are the major constituents of these oils. Conclusions Melaleuca alternifolia and M. × piperita essential oils can be used by residual contact, while those of C. citriodora, M. alternifolia, and M. × piperita by mixing with maize grains. Melaleuca alternifolia essential oil can be used as a fumigant, while those of C. citriodora and S. terebinthifolius as repellents for S. zeamais adults.
Preoperative evaluation of nerve transfer recipients after spinal cord injury using stimulated manual muscle testing
Authors: Cheng Christopher , Perkins Blake , Keith Michael , Bryden Anne , Chepla Kyle J. 
Published: November 2023

Nerve transfer after spinal cord injury has become increasingly popular. Accurate preoperative identification of lower motor neuron involvement in potential recipient nerves is critical. Electrodiagnostic testing has been shown to correlate with intraoperative findings; however, it is time-consuming, costly and may not be readily available. Stimulated manual muscle testing is an alternative diagnostic approach. It is inexpensive and easily done by the surgeon or therapist in the office; however, correlation with intraoperative stimulation has not been reported. A retrospective review was conducted for patients who underwent nerve transfer for tetraplegia with recorded preoperative stimulated manual muscle testing and intraoperative stimulation results. Nine patients including 37 nerve transfers were included. Of the 37 nerve transfers, 36 were accurately graded preoperatively by stimulated manual muscle testing. Stimulated manual muscle testing had a sensitivity of 89%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 97%. This study supports stimulated manual muscle testing for preoperative distinction between upper versus lower motor neuron injuries. Level of evidence: IV
Preoperative Disability Influences Effectiveness of Minimal Clinically Important Difference and Patient Acceptable Symptom State in Predicting Patient Improvement Following Cervical Spine Surgery
Authors: Shahi Pratyush , Maayan Omri , Subramanian Tejas , Singh Nishtha , Singh Sumedha , Araghi Kasra , Tuma Olivia , Asada Tomoyuki , Korsun Maximilian , Sheha Evan , Dowdell James , Qureshi Sheeraz A. , Iyer Sravisht 
Published: November 2023

Study Design Retrospective cohort. Objective To compare the characteristics of the minimal clinically important difference (MCID) and patient acceptable symptom state (PASS) metrics when interpreting Neck Disability Index (NDI) following cervical spine surgery. Methods Patients who underwent primary cervical fusion, discectomy, or laminectomy were included. NDI and global rating change (GRC) data at 6 months/1 year/2 years were analyzed. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of MCID and PASS in predicting improvement on GRC were calculated for the overall cohort and separately for patients with minimal (NDI <30), moderate (NDI 30 – 49), and severe (NDI ≥ 50) preoperative disability. Two groups with patients who achieved PASS but not MCID and patients who achieved MCID but not PASS were analyzed. Results 141 patients (206 responses) were included. PASS had significantly greater sensitivity for the overall cohort (85% vs 73% with MCID, P = .02) and patients with minimal disability (96% vs 53% with MCID, P < .001). MCID had greater sensitivity for patients with severe disability (78% vs 57% with PASS, P = .05). Sensitivity was not significantly different for PASS and MCID in patients with moderate preoperative disability (83% vs 92%, P = .1). 17% of patients achieved PASS but not MCID and 9% of patients achieved MCID but not PASS. Most of these patients still reported improvement with no significant difference between the 2 groups (89% vs 72%, P = .13). Conclusion PASS and MCID are better metrics for patients with minimal and severe preoperative disability, respectively. Both metrics are equally effective for patients with moderate preoperative disability.
Medical Student Experiential Learning in Telesimulation
Authors: Gerstenberger John P. , Hayes Lara , Chow Candace J. , Raaum Sonja 
Published: November 2023

OBJECTIVES Telesimulation utilizes telecommunication technology to engage learners in simulation while in different physical locations. Despite this potential advantage, understanding of the student experience and assessment of student learning in telesimulation activities is limited. This study evaluates medical student emotional experience and self-identified learning in telesimulation through the Kolb experiential learning framework and qualitative analysis. METHODS Fourth-year medical students enrolled in the Spencer Fox Eccles School of Medicine at the University of Utah participated in 3 telesimulation activities as part of a required internal medicine course. Students were surveyed regarding their satisfaction with the activity (N = 114) and responded to questions about their emotional experience and self-identified areas of learning. Free-text responses were analyzed using qualitative content analysis to identify themes until thematic saturation (N = 66). RESULTS Students were highly satisfied with telesimulation, with greater than 90% of students expressing a positive view of simulation realism, debrief quality, and group size. Themes of anxiety and uncertainty, confidence versus incompetence, team dynamics, fun, and difficult patient interaction were identified regarding the emotional experience. Themes of communication and teamwork, managing emotions, information gathering, differential diagnosis, resource reference, executing treatment, and medical knowledge were identified regarding student-identified learning. CONCLUSION In this analysis of medical student experiences with telesimulation, we found students have rich emotional, cognitive, and behavioral experiences and self-identify learning across a variety of domains. Our findings support further study of telesimulation for medical student learning and demonstrate how assessment of outcomes via Kolb framework, using the learner's reflective observation and self-identified learning, may help better define learning outcomes from simulation.
Predicting Psoriatic Arthritis in Psoriasis Patients – A Swiss Registry Study
Authors: Nielsen Mia-Louise , Petersen Troels C. , Maul Lara Valeska , Thyssen Jacob P. , Thomsen Simon F. , Wu Jashin J. , Navarini Alexander A. , Kündig Thomas , Yawalkar Nikhil , Schlapbach Christoph , Boehncke Wolf-Henning , Conrad Curdin , Cozzio Antonio , Micheroli Raphael , Erik Kristensen Lars , Egeberg Alexander , Maul Julia-Tatjana 
Published: November 2023

Background Psoriatic arthritis (PsA) is a prevalent comorbidity among patients with psoriasis, heavily contributing to their burden of disease, usually diagnosed several years after the diagnosis of psoriasis. Objectives To investigate the predictability of psoriatic arthritis in patients with psoriasis and to identify important predictors. Methods Data from the Swiss Dermatology Network on Targeted Therapies (SDNTT) involving patients treated for psoriasis were utilized. A combination of gradient-boosted decision trees and mixed models was used to classify patients based on their diagnosis of PsA or its absence. The variables with the highest predictive power were identified. Time to PsA diagnosis was visualized with the Kaplan-Meier method and the relationship between severity of psoriasis and PsA was explored through quantile regression. Results A diagnosis of psoriatic arthritis was registered at baseline of 407 (29.5%) treatment series. 516 patients had no registration of PsA, 257 patients had PsA at inclusion, and 91 patients were diagnosed with PsA after inclusion. The model’s AUROCs was up to 73.7%, and variables with the highest discriminatory power were age, PASI, physical well-being, and severity of nail psoriasis. Among patients who developed PsA after inclusion, significantly more first treatment series were classified in the PsA-group, compared to those with no PsA registration. PASI was significantly correlated with the median burden/severity of PsA ( P = .01). Conclusions Distinguishing between patients with and without PsA based on clinical characteristics is feasible and even predicting future diagnoses of PsA is possible. Patients at higher risk can be identified using important predictors of PsA.
Defining valid breeding goals for animal breeds
Authors: Wellmann Robin , Gengler Nicolas , Bennewitz Jörn , Tetens Jens 
Published: November 2023

Abstract
Background
The objective of any valid breeding program is to increase the suitability of a breed for its future purposes. The approach most often followed in animal breeding for optimizing breeding goals assumes that the sole desire of the owners is profit maximization. As this assumption is often violated, a generalized approach is needed that does not rely on this assumption.

Results
The generalized approach is based on the niche concept. The niche of a breed is a set of environments in which a small population of the breed would have a positive population growth rate. Its growth rate depends on demand from prospective consumers and supply from producers. The approach involves defining the niche that is envisaged for the breed and identifying the trait optima that maximize the breed’s adaptation to its envisaged niche within the set of permissible breeding goals. The set of permissible breeding goals is the set of all potential breeding goals that are compatible with animal welfare and could be reached within the planning horizon of the breeding program. In general, the breed’s adaptation depends on the satisfaction of the producers with the animals and on the satisfaction of the consumers with the products produced by the animals. When consumers buy live animals, then the breed needs to adapt to both the environments provided by the producers, and the environments provided by the consumers. The profit function is replaced by a more general adaptedness function that measures the breed’s adaptation to its envisaged niche.

Conclusions
The proposed approach coincides with the traditional approach if the producers have the sole desire to maximize their income, and if consumer preferences are well reflected by the product prices. If these assumptions are not met, then the traditional approach to breeding goal optimization is unlikely to result in a valid breeding goal. Using the example of companion breeds, this paper shows that the proposed approach has the potential to fill the gap.
The association between blood pressure control and long-term cardiovascular outcomes in Hypertension coexistent with obstructive sleep apnea
Authors: Yao Xiaoguang , Li Nanfang , Heizhati Mulalibieke , Wang Yingchun , Ma Yue , Wang Run , Zhang Delian , Luo Qin , Hu Junli , Wang Menghui , Zhu Qing 
Published: November 2023

Abstract
Purpose
The goal of blood pressure (BP) control will be lower when hypertensive patients have comorbidities that can affect the risk of cardiovascular diseases. But, the goal of BP control for hypertensive patients coexistent with obstructive sleep apnea (OSA) is not discussed, which is a special population at high risk of cardiovascular diseases.

Patients and methods
Using data from a retrospective study(Urumqi Research on Sleep Apnea and Hypertension (UROSAH) study, we enrolled 3267 participants who were diagnosed with hypertension and performed polysomnography during 2011–2013 to explore the association between BP control and long-term major adverse cardiovascular and cerebrovascular event (MACCE). Outcomes of interest was the levels of BP control, MACCE, cardiac event and cerebrovascular event. Then we calculated the cumulative incidence of MACCE and performed Cox proportional hazards with stepwise models.

Results
379 of 3267 patients experienced MACCE during a median follow-up of 7.0 years. After full risk adjustment, BP control of 120-139/80-89mmHg was associated with the lowest risk of cerebrovascular event (HR: 0.53, 95%CI:0.35–0.82) rather than MACCE and cardiac event in the total cohort. The association did not change much in patients with OSA. When the SBP and DBP were discussed separately, the SBP control of 120-139mmHg or < 120mmHg was associated with the decreased incidence of MACCE and cerebrovascular event. When DBP control < 80 mm Hg, the risk of cerebrovascular event showed 54% decrease [(HR:0.46, 95%CI: 0.25–0.88)] in patients with hypertension and OSA.

Conclusion
In this retrospective study, antihypertensive-drug-induced office and home BP control at 120-139/80-89mmHg showed possible beneficial effect on incident MACCE. However, current results need to be verified in future studies.
Gaps in guideline-recommended anticoagulation in patients with atrial fibrillation and elevated thromboembolic risk within an integrated healthcare delivery system
Authors: Malik Sushmita , Gustafson Shanshan , Chang Huai-En R. , Tamrat Yonas , Go Alan S. , Berry Natalia 
Published: November 2023

Abstract
Background
Atrial Fibrillation (AF) is the leading cause of stroke, which can be reduced by 70% with appropriate oral anticoagulation (OAC) therapy. Nationally, appropriate anticoagulation rates for patients with AF with elevated thromboembolic risk are as low as 50% even across the highest stroke risk cohorts. This study aims to evaluate the variability of appropriate anticoagulation rates among patients by sex, ethnicity, and socioeconomic status within the Kaiser Permanente Mid-Atlantic States (KPMAS).

Methods
This retrospective study investigated 9513 patients in KPMAS’s AF registry with CHADS2 score ≥ 2 over a 6-month period in 2021.

Results
Appropriately anticoagulated patients had higher rates of diabetes, prior stroke, and congestive heart failure than patients who were not appropriately anticoagulated. There were no significant differences in anticoagulation rates between males and females (71.8% vs. 71.6%%, [OR] 1.01; 95% CI, 0.93-1.11; P = .76) nor by SES-SVI quartiles. There was a statistically significant difference between Black and White patients (70.8% vs. 73.1%, P = .03) and Asian and White patients (68.3% vs. 71.6%, P = .005). After adjusting for CHADS2, this difference persisted for Black and White participants with CHADS2 scores of ≤3 (62.6% vs. 70.6%, P < .001) and for Asian and White participants with CHADS2 scores > 5 (68.0% vs. 79.3%, P < .001).

Conclusions
Black and Asian patients may have differing rates of appropriate anticoagulation when compared with White patients. Characterizing such disparities is the first step towards addressing treatment gaps in AF.
Repeatability and agreement of AOCT-1000 M, RTVue XR and IOL master 500 in measuring corneal thickness mapping and axial length applying principle of optical coherence tomography
Authors: Ni Hailong , Xu Suzhong , Tian Li , Mao Jieli , Li Jing , Lin Na , Hu Peike , Wu Zhiyi , Chen Xiang , Bao Zhishu , Zheng Jingwei , Yan Peihua , Deng Ruzhi 
Published: November 2023

Abstract
Purpose
To evaluate the repeatability and agreement of Fourier-domain optical coherence tomography (AOCT-1000 M and RTVue XR) and partial coherence interferometry biometer (IOL Master 500) in measuring corneal thickness mapping and axial length respectively.

Methods
Corneal thickness was measured by AOCT-1000 M and RTVue XR. Axial lengths were measured by AOCT-1000 M and IOL Master 500. The repeatability and agreement of corneal thickness and axial length were calculated in two groups of devices. The intraclass correlation coefficient (ICC) was used to verify the repeatability of the device. The 95% confidence interval of the difference compared to the set cut-off value was used to verify the agreement between the two devices.

Results
A total of 60 subjects with 58 eyes were included. The central corneal thickness measured by AOCT-1000 M and RTVue XR were 504.46 ± 42.53 μm and 504.43 ± 42.89 μm respectively. The average difference between groups was 0.03 ± 4.58 μm, and the 95% confidence interval was (-1.17, 1.24), which was far less than the set threshold value of 15 μm (P < 0.001). Both RTVue XR and AOCT-1000 M had very good ICC values of central corneal thickness (0.998 and 0.994, respectively). The average axial lengths measured by AOCT-1000 M and IOL Master 500 were 24.28 ± 1.25 mm and 24.29 ± 1.26 mm respectively and the 95% confidence interval was (-0.02, 0.01), which was less than the set threshold value of 0.15 mm (P < 0.001). The ICC for both devices were 1.000.

Conclusion
Good repeatability and agreement were seen in measurements of central corneal thickness and axial length by AOCT-1000 M.