bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectories of Parental Warmth and the Role They Play in Explaining Adolescent Prosocial Behavior
Authors: Buckley Lisa , Atkins Tiffany , Perera Withanage , Waller Michael 
Published: October 2023

AbstractAdolescent prosocial behavior suggests social competence and it is associated with greater parental warmth yet the experience of warmth through child and adolescent development is not well understood as it relates to such prosocial behavior. A nationally representative dataset from the Longitudinal Study of Australian Children cohort was used. The analyses involved multiple waves beginning when children were aged 4–5. The main analyses used a sample of 2723 adolescents aged 16–17 years (Mean, S.D. = 16.45, 0.50; 49.2% female, 50.8% male). Parental warmth trajectories (from ages 4–5 through 16–17 years) were created and used to explore the accumulated effect of a lifecourse of parental warmth on adolescent prosocial behavior as measured when adolescents were aged 16–17 years. There were three trajectories described as, consistent (28.7%), slight decline (51.4%), and declining warmth (19.8%). These were associated with prosocial behavior; adolescents with a slight decline in warmth were 2.2 times less likely than those with consistent warmth to have the highest prosocial behavior. Consistent parental warmth likely provides greatest benefit for increased prosocial behavior in mid-adolescence.
Human Rights in Sports Arbitration: What Should the Court of Arbitration for Sport do for Protecting Human Rights in Sports?
Authors: Shinohara Tsubasa 
Published: October 2023

AbstractSports governing bodies establish their sporting rules and regulations. Nevertheless, they confront a complex question concerning whether a female athlete who inherently possesses an advantageous quantity of testosterone may participate in female athletic competitions. InCaster Semenya and Athletics South Africa (ASA) v. IAAF, the Court of Arbitration for Sport (CAS) held that she could not participate in female sports events because “the elevated testosterone levels that such athletes possess can create an insuperable advantage over other female athletes who do not have a 46 XY DSD condition”. Consequently, the CAS ruled that she would no longer be eligible to compete in professional female competitions. In this scenario, the primary focus of this article is to examine how the CAS should address human rights-related issues, even though it is not a human rights court like the European Court of Human Rights (ECtHR) but rather an arbitral tribunal. To achieve this purpose, this article will address the following questions: (1) How can athletes claim a violation of their human rights before the CAS?; and (2) What steps should the CAS take to safeguard human rights in sports? Through this research, it may serve to identify the CAS’s role in human rights protection in sports.
A Visit to the Pediatrician as a Part of Comprehensive Prenatal Care?
Authors: Mei Tiffany L. , Aligne C. Andrew , VanScott Jessica L. 
Published: October 2023

Abstract
Introduction
The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists recommend that expectant parents receive a preventive visit with a pediatrician in the prenatal period (a pediatric prenatal visit, or PPV). Discussing newborn health topics in the prenatal period tends to be more effective than immediately postpartum, and research suggests, for example, that the PPV increases timely childhood immunizations. However, only 22% of expectant parents have these visits, and there are significant disparities by race and income.

Methods
A 2-min online survey with open-ended questions was emailed to 304 eligible obstetrics providers in Rochester, NY. Simple descriptive statistics and chisquare analysis were applied to survey responses. Responses were organized within the framework of knowledge, attitudes, and practices to identify barriers to guideline adherence resulting in chronic under-utilization of the PPV.

Results
Ninety obstetric providers completed the survey. 66 reported awareness of the PPV, and 45 reported referring patients for a PPV. However, in open-ended questions, respondents expressed confusion between the PPV and a “meet and greet” visit with a pediatrician. Some respondents believed that the PPV is not covered by insurance, even though these visits are covered by Medicaid and marketplace insurance. Providers who had personally received one as a parent expressed positive attitudes.

Discussion
These findings indicate that unfamiliarity with the PPV is one barrier to referral. Educating providers about the guideline recommendations, evidence base, and insurance coverage could overcome this barrier. Doing so could reduce disparities in utilization of the pediatric prenatal visit.
Agenda-setting in nascent policy subsystems: issue and instrument priorities across venues
Authors: Lemke Nicole , Trein Philipp , Varone Frédéric 
Published: October 2023

AbstractThe “policy subsystem” has long been a key concept in our understanding of how policies on a given topic are produced. However, we know much less about policymaking in nascent policy subsystems. This article draws on the theories of agenda-setting and venue shopping to argue that the similarity and convergence of policy subsystems’ agendas across different institutional venues and over time are features that distinguish more nascent policy subsystems from their more established, mature counterparts. In simple terms, policy venues’ agendas converge when policy actors begin to discuss the same issues and instruments instead of talking past one another. The article illustrates this argument using textual data on Germany’s emerging Artificial Intelligence (AI) policy: print media debates, parliamentary debates, and a government consultation from the period between November 2017 and November 2019. The insights from our analysis show that actors emphasize somewhat different policy issues and instruments related to AI in different venues. Nevertheless, the longitudinal analysis suggests that the debate does seem to converge across different venues, which indicates the formation of a subsystem-specific policy agenda regarding AI.
Optimal mitigation and control over power system dynamics for stochastic grid resilience
Authors: Stewart Nathan , Arguello Bryan , Hoffman Matthew , Nicholson Bethany , Garrett Richard 
Published: October 2023

AbstractOptimal mitigation planning for highly disruptive contingencies to a transmission-level power system requires optimization with dynamic power system constraints, due to the key role of dynamics in system stability to major perturbations. We formulate a generalized disjunctive program to determine optimal grid component hardening choices for protecting against major failures, with differential algebraic constraints representing system dynamics (specifically, differential equations representing generator and load behavior and algebraic equations representing instantaneous power balance over the transmission system). We optionally allow stochastic optimal pre-positioning across all considered failure scenarios, and optimal emergency control within each scenario. This novel formulation allows, for the first time, analyzing the resilience interdependencies of mitigation planning, preventive control, and emergency control. Using all three strategies in concert is particularly effective at maintaining robust power system operation under severe contingencies, as we demonstrate on the western system coordinating council 9-bus test system using synthetic multi-device outage scenarios.
Learning to Collaborate in a Project-based Graduate Course: A Multilevel Study of Student Outcomes
Authors: Johnsen Mette Mari Wold , Sjølie Ela , Johansen Vegard 
Published: October 2023

AbstractThe context of this study is an interdisciplinary project-based course at a large public university in Scandinavia. The course is taught annually to 3,300 graduate students from all fields of study, and learning to collaborate is a specified learning objective. Similar courses are widespread in higher education institutions worldwide, and empirical evidence of their impacts on students’ skill development is needed. This study examined students’ collaboration skill outcomes; whether outcomes vary by gender, academic achievement, field of study, course format (accelerated and semester based); and variations in outcomes across student groups and course classes. We used a pretest-posttest design in which 89% of students answered a self-report questionnaire about collaboration skills. The results indicate that the participating students’ interdisciplinary, interpersonal, and conflict management skills improved significantly from the beginning to the end of the course (p < .001, d > 0.4). We also found that the accelerated course format positively influenced the students’ conflict management skill outcomes and that the variability in the students’ overall collaboration outcomes was related to their student group (not their course classes). Another important takeaway from our study is that the students’ gender, academic achievement, and field of study showed little impact on their collaboration skills. The non-significance of the measured individual characteristics and the significance of the student group for students’ collaboration outcomes are important reminders for teachers in higher education to guide and support both their students’ learning and group processes in project-based courses.
Analysis of the bacterial and fungal populations in South African sorghum beer (umqombothi) using full-length 16S rRNA amplicon sequencing
Authors: Hlangwani Edwin , Abrahams Adrian , Masenya Kedibone , Adebo Oluwafemi Ayodeji 
Published: October 2023

AbstractThere is a need to profile microorganisms which exist pre-and-post-production ofumqombothi, to understand its microbial diversity and the interactions which subsequently influence the final product. Thus, this study sought to determine the relative microbial abundance inumqombothiand predict the functional pathways of bacterial and fungal microbiota present. Full-length bacterial 16S rRNA and internal transcribed spacer (ITS) gene sequencing using PacBio single-molecule, real-time (SMRT) technology was used to assess the microbial compositions. PICRUSt2 was adopted to infer microbial functional differences. A mixture of harmful and beneficial microorganisms was observed in all samples. The microbial diversity differed significantly between the mixed raw ingredients (MRI), customary beer brew (CB), and optimised beer brew (OPB). The highest bacterial species diversity was observed in the MRI, while the highest fungal species diversity was observed in the OPB. The dominant bacterial species in the MRI, CB, and OPB wereKosakonia cowanii,Apilactobacillus pseudoficulneus, andVibrio alginolyticus, respectively, while the dominant fungal species wasApiotrichum laibachii.The predicted functional annotations revealed significant (p < 0.05) differences in the microbial pathways of the fermented and unfermented samples. The most abundant pathways in the MRI were the branched-chain amino acid biosynthesis super pathway and the pentose phosphate pathway. The CB sample was characterised by folate (vitamin B9) transformations III, and mixed acid fermentation. Biotin (vitamin B7) biosynthesis I andl-valine biosynthesis characterised the OPB sample. These findings can assist in identifying potential starter cultures for the commercial production ofumqombothi. Specifically,A. pseudoficulneuscan be used for controlled fermentation during the production ofumqombothi. Likewise, the use ofA. laibachiican allow for better control over the fermentation kinetics such as carbohydrate conversion and end-product characteristics, especially esters and aroma compounds.
Poultices as biofilms of titanium dioxide nanoparticles/carboxymethyl cellulose/Phytagel for cleaning of infected cotton paper by Aspergillus sydowii and Nevskia terrae
Authors: Mansour Maisa M. A. , Salem Mohamed Z. M. 
Published: October 2023

AbstractIn this study, TiO2 nanoparticle (TiO2NP)-coated film was produced to protect manuscripts against microorganisms using ecofriendly benign materials. As a result, a simple method was created that uses poultice biofilm made of carboxymethyl cellulose (CMC) and Phytagel plant cell (PGP) loaded with TiO2NPs to preserve manuscripts against microbes in an environmentally responsible way. Three volumes (1, 2, 4 mL) of TiO2NPs were put into a biofilm combination to produce the poultices known as CMC/PGP/TiO2-1, CMC/PGP/TiO2-2, and CMC/PGP/TiO2-3. The synthesized TiO2NPs were nearly spherical in shape, small in size (98 nm), and stable (zeta potential value − 33 mV). The results showed that the unique deposition of TiO2NPs on the biofilm surface gave the produced films loaded with TiO2NPs a rough structure. The highest values of mechanical characteristics were determined to be in CMC/PGP/TiO2-1 with values of 25.4 g, 6.6 MPa, and 11.4%, for tensile strength, elongation at break, and tear strength, respectively. Based on molecular identification, the fungus Aspergillus sydowii and the bacterium Nevskia terrae, with accession numbers MG991624 and AB806800, respectively, were isolated and identified from an antiquated manuscript formed from cellulosic fibers. Before the experiments, the produced cotton paper samples were aged, and then, one group was infected for 6 months by A. sydowii and the second group with N. terrae. Following the preparation of a CMC/PGP biofilm loaded with various volumes of TiO2NPs, poultices were applied to infected cotton paper in order to clean it. The infected cotton paper was placed inside the sandwich-like poultices that were created. The poultice CMC/PGP/TiO2-2 demonstrated potential for preventing the growth of A. sydowii and N. terrae-infected cotton paper, when the fibers were saved, cleaned, and coated with CMC/PGP/TiO2-2 after absorbing the fungus and the bacterium and exhibiting exceptional antimicrobial activities. Finally, the novel biofilms have demonstrated their capacity to lessen microbial contamination of cotton paper. In order to generalize the usage of these poultices, it is also advised that they be produced on a large scale and tested on a variety of organic materials in the future.
Graphical Abstract
Evidence-Based Recommendations for the Pharmacological Treatment of Women with Schizophrenia Spectrum Disorders
Authors: Brand Bodyl A. , Willemse Elske J. M. , Hamers Iris M. H. , Sommer Iris E. 
Published: October 2023

Abstract
Purpose of Review
Despite clear evidence that sex differences largely impact the efficacy and tolerability of antipsychotic medication, current treatment guidelines for schizophrenia spectrum disorders (SSD) do not differentiate between men and women. This review summarizes the available evidence on strategies that may improve pharmacotherapy for women and provides evidence-based recommendations to optimize treatment for women with schizophrenia.

Recent Findings
We systematically searched PubMed and Embase for peer-reviewed studies on three topics: (1) sex differences in dose-adjusted antipsychotic serum concentrations, (2) hormonal augmentation therapy with estrogen and estrogen-like compounds to improve symptom severity, and (3) strategies to reduce antipsychotic-induced hyperprolactinemia. Based on three database studies and one RCT, we found higher dose-adjusted concentrations in women compared to men for most antipsychotics. For quetiapine, higher concentrations were specifically found in older women. Based on two recent meta-analyses, both estrogen and raloxifene improved overall symptomatology. Most consistent findings were found for raloxifene augmentation in postmenopausal women. No studies evaluated the effects of estrogenic contraceptives on symptoms. Based on two meta-analyses and one RCT, adjunctive aripiprazole was the best-studied and safest strategy for lowering antipsychotic-induced hyperprolactinemia.

Summary
Evidence-based recommendations for female-specific pharmacotherapy for SSD consist of (1) female-specific dosing for antipsychotics (guided by therapeutic drug monitoring), (2) hormonal replacement with raloxifene in postmenopausal women, and (3) aripiprazole addition as best evidenced option in case of antipsychotic-induced hyperprolactinemia. Combining these strategies could reduce side effects and improve outcome of women with SSD, which should be confirmed in future longitudinal RCTs.
Decision support in engineering design: the ELIGERE open source software platform
Authors: Grazioso Stanislao , Caporaso Teodorico , Di Gironimo Giuseppe 
Published: October 2023

AbstractIn engineering design, the selection of the optimal design solution represents a critical phase for the development of successful products. In this paper, we present ELIGERE, an open source decision support system targeted at engineering design applications. It allows to rank multiple design solutions with respect to different evaluation criteria according to the evaluations provided by a group of experts. ELIGERE is composed by three main modules: (1) a distributed web application, for generation and participation to the decision making session; (2) a mathematical engine, based on the fuzzy analytical hierarchy process, to quantify the results of the decision making session according to the evaluation of the experts; (3) a relational database, to collect and store data. The most important contribution of this paper is introducing a practical and effective software tool that facilitates decision-making analysis based on the fuzzy analytical hierarchy process, thereby allowing better-informed choices on concept selection, as it has been designed with a specific focus on the engineering field. In this paper we describe the key concepts of ELIGERE and its modalities of use in several real use cases. Finally, we compare ELIGERE with the widely used general purpose decision support software based on the fuzzy analytical hierarchy process.
Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma
Authors: Suzuki Hiroyuki , Iwamoto Hideki , Tanaka Toshimitsu , Sakaue Takahiko , Imamura Yasuko , Masuda Atsutaka , Nakamura Toru , Koga Hironori , Hoshida Yujin , Kawaguchi Takumi 
Published: October 2023

Abstract
Background & aims
Combination immunotherapy refers to the use of immune checkpoint inhibitors (ICI) and molecular-targeted agents (MTA), which have recently been approved for the treatment of advanced hepatocellular carcinoma (HCC). Owing to its relatively low antitumor effect (up to 30%), sequential therapy following ICIs treatment is required in patients with HCC. This study aimed to determine the impact of MTAs on the tumor immune microenvironment (TIME).

Methods
We established immune syngeneic orthotopic HCC mouse models using Hep-55.1C and Hep-53.4, and treated them with MTAs (lenvatinib, sorafenib, regorafenib, cabozantinib, and DC101 as anti-vascular endothelial growth factor receptor-2 antibodies, and AZD4547 as a fibroblast growth factor receptor (FGFR)-1/2/3/4 inhibitor) for 2 weeks. Subsequently, alterations in the TIME caused by MTAs were evaluated using immunohistochemistry (antibodies for CD3, CD8, Foxp3, Granzyme B, Arginase-1, NK1.1, F4/80, CD11c, PD-1, and PD-L1). We conducted RNA-seq analysis using lenvatinib- and AZD4547-treated tumors. To confirm the clinical relevance of these findings, we analyzed the transcriptome data of human HCC cells (MHCC-97H) treated with various concentrations of lenvatinib for 24 h using RNA-seq data from the Gene Expression Omnibus database.

Results
The number of Foxp3- and F4/80-positive cells in the TIME was decreased in many MTAs. Cabozantinib increased the numbers in NK1.1-, Granzyme B, and CD11c-positive cells. Lenvatinib and AZD4547 increased the number of CD8, Granzyme B, and PD-L1-positive cells. Gene ontology enrichment analysis revealed that lipid metabolism-related genes were downregulated by lenvatinib and AZD4547. In total, 161 genes downregulated by FGFR inhibition in rodent models overlapped with those downregulated by lenvatinib in human HCC cells.

Conclusions
In this study, we showed that cabozantinib activated the innate immune system, and lenvatinib and AZD4547, which commonly inhibit FGFR signaling, altered TIME to a hot immune state by downregulating lipid metabolism-related genes. These findings support the therapeutic use of combination immunotherapies.
Are Schools in Prison Worth It? The Effects and Economic Returns of Prison Education
Authors: Stickle Ben , Schuster Steven Sprick 
Published: October 2023

AbstractRecent expansions in prison school offerings and the re-introduction of the Second Chance Pell Grant have heightened the need for a better understanding of the effectiveness of prison education programs on policy-relevant outcomes. We estimate the effects of various forms of prison education on recidivism, post-release employment, and post-release wages. Using a sample of 152 estimates drawn from 79 papers, we conducted a meta-analysis to estimate the effect of four forms of prison education (adult basic education, secondary, vocational, and college). We find that prison education decreases recidivism and increases post-release employment and wages. The largest effects are experienced by prisoners participating in vocational or college education programs. We also calculate the economic returns on educational investment for prisons and prisoners. We find that each form of education yields large, positive returns due primarily to the high costs of incarceration and, therefore, high benefits to crime avoidance. The returns vary across education types, with vocational education having the highest return per dollar spent ($3.05) and college having the highest positive impact per student participating ($16,908).
A Comparative Study of Effects of Biodegradable and Non-biodegradable Microplastics on the Growth and Development of Black Soldier Fly Larvae (Hermetia illucens)
Authors: Heussler Carina D. , Dittmann Isabel L. , Egger Bernhard , Robra Sabine , Klammsteiner Thomas 
Published: October 2023

Abstract
Purpose
This study aimed to investigate the digestion process of biodegradable and non-biodegradable microplastics (MPs) within black soldier fly larvae (BSFL) and assess their impact on larval growth and development. The goal was to understand the fate of MPs within BSFL, considering their potential for waste conversion polluted with MPs.

Methods
BSFL were exposed to two types of MPs, and their growth, development, potential accumulation and excretion of MPs were monitored.

Results
The findings revealed that the MPs accumulated solely in the larval gut and had no adverse effects on the growth and development of BSFL. Larvae efficiently excreted MPs before reaching the pupation stage.

Conclusion
This research emphasizes the potential of BSFL as a bioconversion agent for organic waste, even in the presence of MPs. The effective excretion of MPs by BSFL before pupation suggests their ability to mitigate potential harm caused by MP accumulation. The fact that BSFL may excrete MPs before pupation would contribute to their safe use as animal feedstock. A careful evaluation of the effects of using BSFL reared on contaminated substrates especially containing visually non-detectable residuals like nanoplastics, chemicals or toxic metals and further examination of the broader implications for waste management and sustainable livestock farming remains important.

Graphical Abstract
Experimental design outlining the workflow for the analyses used to investigate the effect of two types of microplastics, polyamide (PA), and polylactic acid (PLA), on growth and development of black soldier fly larvae.