bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Elevated Vacuum Socket System-Based Below-the-Knee Prosthetic Improves Residual Limb Health as Determined by Non-Invasive Spatial Frequency Domain Imaging of Tissue Oxygenation and Hemoglobin Perfusion
Authors: GNYAWALI SURYA C. , Masry Mohamed El , Dennune Jeffry , Ghatak Subhadip , Pratt Whitney M. , Gordillo Gayle M. , Sen Chandan K. , Roy Sashwati 
Published: February 2024

Abstract

Preserving residual limb health in lower-limb amputees is of paramount significance, given its pivotal role in their overall well-being and mobility. This work reports that the elevated vacuum suspension (EVS) system improves blood hemoglobin oxygenation and reduces the potential risk of limb ischemia compared to the standard-of-care (SOC) socket-liner system via a global oxygen mapping modality of spatial frequency domain imaging (SFDI) to assess skin oxygenation and hemoglobin perfusion qualitatively and quantitatively in individuals with lower-limb loss. Conventional methodologies, such as pulse oximetry, are recognized for their inherent limitations in yielding localized tissue oxygenation measurements, thereby failing to offer a comprehensive evaluation. The introduced imaging modality is postulated to provide a more holistic and detailed analysis of the content of tissue chromophores compared to traditional point measurement techniques. The research protocol enlisted six subjects who participated in a protracted 32-week regimen. This encompassed an array of assessments, including evaluations of limb health, socket fit tests, and surveys gauging the impact of socket pressure on the limb skin, both pre-, and post-physical activity. This study also sought to ascertain the efficacy of an experimental prosthesis incorporating EVS technology, contrasting its performance against standard-of-care prostheses. The findings indicate that compared to SoC, the use of the EVS socket system has benefited the effects of residual limb as measured by improved tissue oxygen and better deeper tissue hemoglobin perfusion. Such insightful data holds substantial promise in aiding clinicians to render more informed decisions about managing individuals with limb loss.
FOUR has the Best Predictive Validity for Patients with Severe Consciousness Disorders or Mechanical Ventilation
Authors: Liu Dandan , Cheng Jiaqi , Li Bianfang , Zhou Yuchen , Wang Yuefu , Li Guanggang 
Published: February 2024

Abstract

Background: To investigate the predictive validity of GCS, GCS-Pupils and FOUR for patients admitted to the Neuro-Surgical ICU.
Methods: In this retrospective study, all the adult patients admitted to Neuro-Surgical ICU from January 2017 to January 2020 were recruited. The GCS, GCS-pupils and FOUR scores were obtained at their ICU admission. Correlation analyses were conducted between the scores and the outcomes.
Results: 181 patients were included in the outcomes analysis. The average scores of GCS was 5 (3-9), GCS-Pupils was 5 (1-10) and FOUR was 7 (0-16).The scores of all the three scales were correlated with the primary outcome (6-month GOSE), FOUR had the best predictive value(OR=0.5, 95%CI: 0.4~0.5) and the most refined cut-off value.The scores of the FOUR and GCS-Pupils were correlated with all the secondary outcomes(p<0.05), the scores of GCS was not correlated with the ICU LOS and MV time(p>0.05).
In the subgroup analysis of more severe patients, the scores of FOUR were correlated with all the outcomes(p<0.01) except the ICU LOS and MV time(p>0.05), the scores of the GCS-Pupils were not correlated with the outcomes(p>0.05).
Conclusions: FOUR has the best predictive validity for patients admitted to NSICU, especially for those with severe consciousness disorders or mechanical ventilation.
Characterization of a novel Pseudomonas aeruginosa phage species PaYy-2
Authors: Fang Lihua , Ning Jie 
Published: February 2024

Abstract
A novel Pseudomonas aeruginosa phage, PaYy-2 was isolated from a lake in China and its genome has been sequenced and characterized. Payy-2 has a 92,348 bp double-stranded DNA genome encoding 168 proteins, which has 68% similarity with the genome of the known Pseudomonasphage YS35. According to the phylogenetic analysis, the putative RNA polymerase was similar to that of Pseudomonasphage SRT6（similar index 94%）and the putative terminase_large_subnit was similar to that of the phages YS35（similar index 96%）which belongs to the Pakpunavirus genus. We also observed the morphology of the new phage by TEM whcih demonstrated the phage tails and particles morphology. All these findings indicate that the PaYy-2 phage can be classified as a new species of the Pakpunavirus genus of the family Myoviridae for the first time.
An Improved LM-GN Assisted INS/GNSS Dual-Threshold Fault Detection Algorithm
Authors: Zhao Guiling , Jiang Zihao , Wang Jinbao , Gao Shuai 
Published: February 2024

Abstract

The conventional residual chi-square detection method has a low detection rate for slow-changing faults in the integrated navigation system of the Inertial Navigation System/Global Navigation Satellite System (INS/GNSS). To tackle this issue, we propose an improved Levenberg-Marquardt-Gauss-Newton (LM-GN) algorithm to aid the integrated navigation system in detecting slow-changing faults. The algorithm is designed to tackle this issue. When constructing the detection statistics, the measurement data is assessed independently for failures. The paper proposes a dual-threshold detection method. It then divides the measurement data into three parts for classification processing. When the detection data falls within the two thresholds, the trust region technology is used. It improves the iteration speed and accuracy of the LM algorithm and improves the sensitivity of fault detection. An experiment is conducted to validate the proposed method's effectiveness. It tests fault detection in the INS/GNSS integrated navigation system. The experimental results demonstrate that the improved LM-GN algorithm-assisted dual-threshold fault detection reduces the system's missed fault alarm rate by 46.7%. It also improves speed accuracy by 43.9% compared to the traditional dual-threshold residual chi-square detection method. Additionally, the positional accuracy has increased by 16.9%.
Allelopathic effects of rapeseed (Brassica juncea) on invasive weed Phalaris minor Retz
Authors: Xu Gaofeng , Shan Shicai , Yun Zhang , Clements David Roy , Yun-hai Yang , Shao-song Yang , Feng-ping Zhen , Gui-mei Jin , Zhang Fu-dou , Feng Zhi-ke , Dong Li-yao 
Published: February 2024

Abstract

Background
Growing allelopathic crops to control invasive weeds is considered as an environmental friendly, and economically sustainable approach, understanding the reasons are essential for current and future green control of invasive weeds. Phalaris minor Retz. is one of the most troublesome invasive weeds worldwide. Our previous studies found that rapeseed(Brassica juncea)exhibited strong inhibitory effects of this weed in agroecosystems, but it is unknown whether allelopathic effects are involved in this process. In this study, we assessed the allelopathic effects of B. juncea to P. minor, then, allelochemicals were separated and identified from its leaves, further, biological activity and physiological responses by some individual compounds were investigated.
Results
Our results showed that water extracts from roots, stems, and leaves of B. juncea have strong allelopathic potential which can significantly inhibit the seedling growth of P. minor, and leaves have the strongest allelopathic inhibitory effects. Different solvents extracts from leaves water extracts of B. juncea significantly inhibited seed germination and seedling growth of P. minor at higher concentration (20 mg/mL), but no significantly inhibited at lower concentration (1.25 mg/mL), allelopathic effects of different solvents extracts were ranked in order from petroleum ether (strongest), ethyl acetate (moderate), N-butyl alcohol, and residual water (least). The petroleum ether extracts of B. juncea affected the protective oxidase activity and chlorophyll content, resulting in a significant increase of malondialdehyde (MDA) content and a significant reduced superoxide dismutase (SOD) activity and chlorophyll content of P. minor. Twenty-one components were identified by GS-MS, with proportion of 96.47% of petroleum ether extracts of B. juncea. The major components were erucic acid (EA) (19.08%), palmitic acid(PA) (14.16%), dibutyl phthalate(DP) (13.19%), ethyl palmitate(EP) (12.31%), linoleic acid(LA) (9.43%), and oleic acid(OA) (6.24%), among which components PA, EP, and LA exhibited strong inhibitory activity against P. minor.
Conclusions
Overall, these relults suggested that B. juncea has strong allelopathic inhibitory effect on P. minor, and PA, EP and LA were major compounds of petroleum ether extract of B. juncea and exhibited strong inhibitory activity against P. minor, suggested that B. juncea can be used for ecological control and developing environmentally friendly herbicides to control P. minor.
Identification of Lysine lactylation (kla) -related lncRNA signatures using XGBoost to predict prognosis and immune microenvironment in breast cancer patients
Authors: Chen Yu , Lin Feng , Li Hang , Liu Huan , Shen Jianlin , Zheng Lemin , Huang Shunyi 
Published: February 2024

Abstract

Breast cancer (BC) stands as a predominant global malignancy, significantly contributing to female mortality. Recently uncovered, histone lysine lactylation (kla) has assumed a crucial role in cancer progression. However, the correlation with lncRNAs remains ambiguous. Scrutinizing lncRNAs associated with Kla not only improves clinical breast cancer management but also establishes a groundwork for antitumor drug development. We procured breast tissue samples, encompassing both normal and cancerous specimens, from The Cancer Genome Atlas (TCGA) database. Utilizing Cox regression and XGBoost methods, we developed a prognostic model using identified kla-associated lncRNAs. The model's predictive efficacy underwent validation across training, testing, and the overall cohort. Functional analysis concerning kla-related lncRNAs ensued. We identified and screened 8 kla- associated lncRNAs to formulate the risk model. Pathway analysis disclosed the connection between immune-related pathways and the risk model of kla-associated lncRNAs. Significantly, the risk scores exhibited a correlation with both immune cell infiltration and immune function, indicating a clear association. Noteworthy is the observation that patients with elevated risk scores demonstrated an increased tumor mutation burden (TMB) and decreased tumor immune dysfunction and exclusion (TIDE) scores, suggesting heightened responses to immune checkpoint blockade. Our study uncovers a potential link between Kla-related lncRNAs and BC, providing innovative therapeutic guidelines for BC management.
Synthesis and gamma-ray shielding efficiency of borosilicate glasses doped with Zinc oxide: Comparative study
Authors: Saleh Abdelmoneim , Sayyed M. I. , Kumar Anjan , Mansour Fatma Elzahraa 
Published: February 2024

Abstract

This study examined the suitability of several glass compositions as a gamma-ray shielding substance. The compositions tested were of varying ZnO concentrations, specifically (60-x) B2O3 − 10Na2O − 15SiO2 − 5Al2O3 - (x + 10 )ZnO (where X = 5, 10, 15 and 20 mol%). Measurements were performed at energy levels of 0.6642, 1.1776, and 1.3343 MeV radiated from Cs137 and Co60 point sources along with a scintillation detector [NaI(TL)]. We investigated the critical properties related to gamma radiation shielding, determining the effective atomic number (Zeff), electron density (Nel), half-value layer (HVL), linear attenuation (µ) and mass attenuation (µm) coefficients, and mean free path (λ). Our results show that all glass compositions provide adequate protection against gamma radiation at the specified energy levels. The values of µ went up from 0.157 to 0.214 cm− 1 (0.6642 MeV), from 0.119 to 0.160 cm− 1 (1.1776 MeV), and from 0.114 to 0.151 (1.3343 MeV). For samples B1 and B4, the observed HVL values dropped from 4.41, 5.84, and 6.12 cm to 3.21, 4.31, and 4.61 cm at 0.6642, 1.1736, and 1.3343 MeV, respectively. Among the materials tested, prepared glasses show higher shielding capacity compared to regularly used glass and concrete samples. The study highlights these glass compositions' potential as practical materials that can shield gamma radiation.
Effects of on TLRs/MyD88 related pathways with infected by spring viremia of carp virus (SVCV) in Common Carp
Authors: Jiao Xue , Guo Zheng-yao , Dai Jing , Qian Ai-Dong , Li Yue-hong 
Published: February 2024

Abstract
Spring Viremia of Carp (SVCV) is a highly lethal viral infection that poses a significant threat to the survival and economic value of carp populations. The innate immune system serves as a robust defense mechanism against microbial intrusions. In this study, we delve into the intricate interaction between the Toll-like receptor (TLR) signaling pathway and SVCV.Our research findings unveil a noteworthy response to SVCV infection in EPC cells, characterized by an upregulation in the mRNA expression of key TLRs, namely TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9. These findings strongly suggest their pivotal role in triggering the immune response against SVCV. Furthermore, our investigation delves into the therapeutic potential of ST2825, a MyD88 inhibitor, in mitigating the impact of SVCV infection. We observe that ST2825 effectively suppresses the production of the MyD88 protein, resulting in a notable reduction in mRNA expression levels of SVCV-G. This inhibition extends to the modulation of immune-related genes such as IRAK1 and IRF7, showcasing its potential as a therapeutic intervention. Notably, the ST2825-treated group demonstrates a significant decrease in the rate of cell apoptosis, underlining its potential in mitigating the detrimental effects of SVCV infection. Additionally, our study explores the mRNA expression of TRAF6, IRAK1, IRF3, and IRF7 in renal tissue. We observe a substantial increase in their expression levels in both the ST2825 and SVCV groups when compared to the control group, shedding further light on the intricate interplay within the TLR/MyD88-associated pathways during SVCV infection. In conclusion, our research enhances our understanding of how SVCV infection influences the TLR/MyD88-associated pathways. These findings provide critical insights into SVCV development and lay the groundwork for potential disease control strategies and the development of innovative therapeutic approaches.
Examining the Factors that Impact the Formation of Barite Scale in Water Injection Operations: Experimental Study and Quantification of Scale Formation
Authors: Hosny R. , Selim Hanaa , Mubarak Mahmoud. F 
Published: February 2024

Abstract
The accumulation of barium sulfate scale presents significant challenges in oil and gas production processes that involve water injection, leading to operational hurdles and reduced efficiency. This in-depth study investigates the complex factors influencing the formation of barium sulfate scale, aiming to quantify the extent of scale accumulation. The experimental methodology adopted in this research involves meticulous sample preparation, precise measurements of turbidity and electrical conductivity, rigorous jar testing, thorough analysis of the scale, and systematic evaluation across various experimental parameters. Through this comprehensive approach, the study aims to provide valuable insights into the compatibility of brine and the intricate composition of barium sulfate scale crystals. By examining the results and conducting a thorough analysis, the research seeks to contribute essential knowledge to the understanding of barium sulfate scale deposition, ultimately offering solutions to mitigate its impact on operational efficiency in oil and gas production processes involving water injection.
Potentiation of anti-obesity activity of berberine through its encapsulation in guar-acacia gum nanocomplexes in Wistar albino rats
Authors: Bakshi Jyoti , Lathar Prity , Verma Assim , Lather Deepika , Grewal Sapna , Dhingra Dinesh , Kumari Santosh 
Published: February 2024

Abstract

Berberine is a promising bioactive compound that has gained great attention against numerous diseases but its low solubility and poor systemic bioavailability hinders its clinical applicability. Therefore, this study attempted to enhance the therapeutic potential of berberine by its nanoencapsulation. Berberine loaded guar-acacia gum nanocomplexes (Ber/Gu-AGNCs) were prepared by ionic complexation method; characterized and evaluated for anti-obesity activity in high fat diet (HFD) induced obese rats. HFD was given to animals for 6 consecutive weeks. Orlistat (20 mg/kg, p.o.), berberine (10 mg/kg), Ber/Gu-AGNCs (10 and 20 mg/kg, p.o) and Gu-AGNCs (blank) were administered once a day after giving HFD for 6 weeks; and continued up to 12 weeks along with HFD. Obesity was evaluated by the measurement of morphological parameters, blood glucose, serum lipid profiles, liver enzymes and levels of oxidative stress markers. Moreover, histopathological studies of liver and adipose tissue were also carried out. The results showed that Ber/Gu-AGNCs exhibited spherical morphology and narrow size distribution. In addition, Ber/Gu-AGNCs were significantly more effective in controlling the body weight, BMI, adiposity index, liver index, blood glucose levels, serum lipids and oxidative stress levels in comparison to berberine in HFD-induced obese rats. Furthermore, histopathological examination of liver and adipose tissue revealed the anti-obesity effect of Ber/Gu-AGNCs (10 and 20 mg/kg), as indicated by decrease in hepatosteatosis and inflammation in liver tissue; and decrease in the size of adipocytes in fat depots. Thus, nanoencapsulation of berberine into gum nanocomplexes displayed better anti-obesity activity when compared to free berberine.
Extending X-reality technologies to digital twin in cultural heritage risk management：A comparative evaluation from the perspective of situation awareness
Authors: Guo Yuqing , Lu Shizhu , Shen Min , Liu Lin , Huang Wei , Yi Xiaolie , Zhang Jifa 
Published: February 2024

Abstract

Digital twins possess characteristics such as real-time capability, high precision, and high integration. The digital twin system for cultural heritage risk management includes comprehensive information about heritage, contextual data, and expert knowledge. Considering the role of Situational Awareness (SA), it facilitates more efficient risk assessment, analysis, and strategic decision-making for management personnel, thereby reducing damage to cultural heritage.This study extends X-reality technologies into the digital twin system for cultural heritage risk management. It simulates three sets of procedures for remote risk management of cultural heritage (2D desktop, VR, and AR) and explores the effectiveness of VR and AR in enhancing situational awareness from three dimensions of SART (SART-DAR, SART-SAR, SART-UOS). Additionally, we further analyze how the technological attributes of VR and AR (immersion and interactivity) impact the functional mechanism of situational awareness.The results indicate that, compared to the traditional 2D desktop, VR and AR have advantages in enhancing situational awareness of heritage risk. However, in AR mode, SART-DAR and SART-SAR dimensions did not show significant improvement. Furthermore, there is a significant difference in immersion's impact on the SART-DAR dimension. Regarding interactivity, although the results show differences in the impact on the SART-DAR dimension between VR and AR, no significant differences were observed.This study provides design references for building a digital twin system for cultural heritage risk management by deeply understanding the impact of X-reality technologies on the functional mechanism of cultural heritage risk situational awareness. Simultaneously, it offers insights for heritage site managers, heritage experts, and relevant stakeholders to enhance efficiency in risk perception.
COVID-19 and its impact on biodiversity in coffee farms in the Andean landscape
Authors: Medina David Coral , Fernández Germán Rivera , Rosero-García Doris , Martinez Ricardo Pereira , Galindo Leonardo Fabio 
Published: February 2024

Abstract
In Buesaco (BUE) and The Tablón of Gómez (TTG), farms in the Nariño Department fauna likely benefited from reduced human activities by COVID-19. However, this phenomenon has not been documented, and perhaps this article is the first on this topic. A survey was conducted on 431 farmers to identify fauna sightings and plant species. The non-parametric Kruskal Wallis test and multiple regression explored variables influencing species composition. Additionally, BUE and TTG’s fauna composition reports were utilized in a multi-temporal analysis before and after the COVID-19 lockdown. Analyzing data resulted in a compilation of lists containing the names of existing plant and fauna species. Sixty-four species of fauna were mentioned in BUE and TTG; birds accounted for 50%, and mammals accounted for 25%. Sciurus pucheranii had the highest mention frequency (MF), with 165 times by the producers in BUE and 188 times in TTG. This is the first record for the Nariño Department. According to the dominance index, four shade species within coffee plantations are considered the most dominant. Besides, five forest species around coffee are considered dominants. The Kruskal Wallis test (p = 0,013) and the regression analyses (R2 = 0,14) indicate that the null hypothesis should be rejected (p > 0.05). Species interaction between forest and fauna probably did not influence the increased biodiversity. The COVID-19 lockdown impacted how other fauna species appeared in BUE and TTG. Moreover, from 2021 to 2023, it can be determined that more species are mentioned than those recorded in years before COVID-19.
Postoperative urinary retention induced hyponatremic seizure following total knee arthroplasty with an enhanced recovery after surgery protocol: a case report and literature review
Authors: Lee Hsin-Hsin , Tsai Yuan-Hsin 
Published: February 2024

Abstract
Background: Although the enhanced recovery after surgery (ERAS) protocol in total knee arthroplasty (TKA) aimed at facilitating overall outcomes and reducing complication rates, the incidence of postoperative urinary retention (POUR) is still of concern.
Case presentation: A 70-year-old woman underwent TKA with an ERAS protocol for severe osteoarthritis of right knee. She developed generalized tonic-clonic seizure on post-operative day 1. The occurrence of altered consciousness initiated further investigation, revealing hyponatremia of 117 mEq/L and significant urinary retention. Following urinary catheterization, during which 1350 mL of urine was immediately drained and an additional 2550 mL over the next 8 hours, her sodium level improved to 130 mEq/L under regular saline solution supply, accompanied by a marked improvement in consciousness. Subsequently, she was discharged with a normal sodium level and complete recovery of the conscious level. The prompt resolution of neurological symptoms highlights the correlation between hyponatremia-induced seizures and POUR.
Conclusions: Hyponatremic seizure related to POUR after TKA with an ERAS protocol represents an uncommon yet potentially lethal complication. This case emphasized the importance of recognizing and addressing hyponatremic seizure as well as considering POUR as a potential cause despite the implementation of ERAS protocol. Urinary catheterization and early removal are suggested in elderly patients scheduled for TKA under spinal anesthesia.