bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possibilities of Therapeutic Angiogenesis in Patients with Critical Lower Limb Ischemia
Authors: Mikhailov I. P. , Borovkova N. V. , Kozlovsky B. V. , Ponomarev I. N. , Kudryashova N. Ye. , Leshchinskaya O. V. 
Published: January 2024

Two clinical observations of effective treatment of patients with critical ischemia of the lower extremities using plasma-free lysate autologous platelets. Both patients were male, 73 and 53 years old. Both were diagnosed with total damage to the arteries of the infrainguinal zone. One of them had previously undergone endarterectomy from the femoral artery with subsequent thrombosis. After examination and joint discussion with x-ray endovascular surgeons, they were found inoperable. Due to the ineffectiveness of standard conservative therapy, the patient was offered local administration of plasma-free lysate autologous platelets. After receiving written informed consent, the procedure for collecting venous blood and obtaining plasma-free lysate autologous platelets and the introduction of this drug into the muscles of the leg from the side of ischemia according to the original method. The method for assessing microcirculation was three-phase scintigraphy : before treatment, both patients showed a significant decrease in the inclusion of osteotropic radiopharmaceutical in the soft tissues of the legs. For areas of radiopharmaceutical hyperfixation, relative accumulation coefficients were calculated: for one patient, the calculation results demonstrated the formation of foci of aseptic necrosis. When patients were re-hospitalized after 6 months, there was an improvement in local status and relief of rest pain. According to scintigraphy, a significant improvement in microcirculation was noted; no foci of aseptic necrosis were identified. Thus, the use of plasma-free lysate autologous platelets in combination with complex conservative therapy has demonstrated positive results; this method can be considered as an alternative revascularization ischemic limb.
Design of a Drying Equipment Moringa Leaf with Utilizing Temperature Air Conditioning Condenser
Authors: Masykur Masykur , Saputra Maidi , Munawir Al , Pribadyo Pribadyo , Jalil Muhammad , Muzakir Muzakir , Yuvenda Dori , Setiawan M. Yasep , Y Fadhil 
Published: January 2024

This study conducted to get drying equipment a moringa leaf using air temperature from an air conditioning condenser. The first steps taken were collecting research literature, formulating problems, and design a drying equipment moringa leaf (moringa oleifera) using air temperature from an air conditioning condenser. Drying equipment tool made from plywood, wood, aluminum foil, styrofoam, and pipe channel to drying equipment. It works by utilizing air from the air conditioning condenser which is channeled through a pipe channel to drying equipment. The test was carried with modification intake channel to drying equipment without suction fan and using suction fan. Data collection is carried out every 30 minutes for 7 hours which starting from 10.00 AM to 05.00 PM. A sample of 800 grams of wet moringa leaf was placed on each drying rack. The result study without suction fan in the drying equipment show average temperature air from the condenser of 31.17 °C, average humidity of 68.8%, and a reduction in water content of moringa leaf of 35.5%. Meanwhile, the test using an air suction fan in the drying equipment was average temperature air from the condenser 34.10 °C, average humidity was 62.30% and the reduction in water content of moringa leaf was 40.8%. The drying rate of moringa leaf in the test using an exhaust fan is 0.0138 kg/hour, while the drying rate of moringa leaf in the test without using an exhaust fan is 0.01 kg/hour.
PREVALENSI PENDERITA OSTEOARTHRITIS LUTUT YANG MENDAPATAKAN PELAYANAN FISIOTERAPI DI RS YUKUM MEDICAL CENTER, LAMPUNG TENGAH
Authors: Khasanah Al Um Aniswatun , Fitri Diah Purnama , Yudistira Efraldo 
Published: January 2024

Osteoartritis lutut ini lebih umum seiring mengenai apabila seiring bertambahnya usia.Modalitas konservatif yang tersedia untuk pengobatan Osteoartritis lutut dengan melakukan pelayanan fisioterapi yang mana fisioterapi membantu memulihkan gerak dan fungsi pada tubuh manusia, dan fokus utama dalam manajemen Osteoartritis lutut adalah mempromosikan manajemen diri, mengurangi rasa sakit, mengoptimalkan fungsi, dan memodifikasi proses penyakit dan efeknya.Untuk itu perlu mengetahui bagaimana prevalensi kasus Osteoartritis lutut yang mendapatkan pelayanan fisioterapi terutama di RS Yukum Medical Center, Lampung Tengah. Rancangan Penelitian ini merupakan penelitian deskriptif analitik Penelitian dilakukan bulan Januari 2023, dan data penelitian diperoleh dari bulan Januari- Desember 2022, dengan kriteria data sampel yang diambil diagnosa oleh dokter Osteoartritis lutut yang melakukan pelayanan Fisioterapi di RS Yukum Medical Center, Lampung Tengah dengan jumlah sampel yaitu 143. dari data tersebut diperoleh bahwa penderita Osteoarthritis Lutut paling banyak direntang usia 51-60 tahun, jenis kelamin perempuan paling banyak, pekerjaan petani juga paling banyak mengalami Osteoarthritis Lutut dan rata-rata dalam 6x kunjungan fisioterapi mengalami penurunan nyeri.
FISIOTERAPI PADA KASUS DROP FOOT DI RS KELET DONOROJO JEPARA: STUDI KASUS
Authors: Ratnasari Eka Febri , Herawati Isnaini , Prihastomo Teguh 
Published: January 2024

Drop Foot adalah kondisi umum di mana seseorang kehilangan kendali atas dorsofleksi pergelangan kaki. Seringkali, disfungsi saraf peroneal umum (Common Peroneal Nerve) menyebabkan kelumpuhan otot dorsofleksi pergelangan kaki termasuk; tibialis anterior, dorsi flexors jari kaki, ekstensor digitorum brevis, dan ekstensor hallucis longus. Kusta adalah penyakit menular kronis yang disebabkan oleh Mycobacterium Lepra. Deformitas fungsional yang umum ditemukan pada kasus kusta adalah ulkus tangan, ulkus kaki, drop hand, drop foot dan juga claw hand. Drop foot ditemukan pada 2% hingga 5% pasien yang baru didiagnosis dengan kusta. Tujuan dari penelitian ini adalah untuk mengetahui apakah modalitas fisioterapi berupa TENS, Streching, dan Strengthening efektif digunakan dalam penanganan kasus drop foot. Dengan metode penelitian berupa case study yang dilakukan di RS KELET DONOROJO pada bulan Desember 2021. Hasil penelitian di dapatkan bahwa intervensi fisioterapi yang dilakukan selama 6 kali pertemuan menunjukkan hasil akhir berupa penurunan nyeri, peningkatan lingkup gerak sendi dan peningkatan kemampuan fungsional pasien.
Drop Foot is a common condition in which a person loses control of the dorsiflexion of the foot. Occasionally, generalized peroneal nerve dysfunction causes paralysis of the dorsiflexion muscles of the foot including; tibialis anterior, dorsi flexor toes, extensor digitorum brevis, and extensor hallucis longus. Leprosy is an infectious disease caused by Mycobacterium leprosy. Functional deformities commonly found in cases of leprosy are hand ulcers, foot ulcers, drop hands, drop feet and claw hands. Foot fall in 2% to 5% of patients newly diagnosed with leprosy is found. The purpose of this study was to determine whether physiotherapy modalities such as TENS, stretching, and stretching are effective in treating drop foot cases. With a research method in the form of a case study conducted at RS KELET DONOROJO in December 2021. The results showed that the physiotherapy intervention carried out for 6 meetings showed the final result in the form of decreasing pain, increasing joint ability and increasing the patient's functional ability.
A MANAJEMEN FISIOTERAPI PADA KASUS RETENSI SPUTUM et causa IMMOBILISASI POST CRANIOTOMY
Authors: Dzuria Rahma Affanatu , Susilo Taufik Eko 
Published: January 2024

ABSTRAK
Pendahuluan: Craniotomy adalah prosedur operasi untuk membuka bagian tengkorak (cranium) dengan tujuan memperbaiki dan mengetahui kerusakan yang ada di otak. Tindakan ini dilakukan karena adanya tumor otak, hematoma, trauma ataupun infeksi pada otak. Kondisi ini bisa menimbulkan probematik fisioterapi akibat tirah baring yang lama, diantaranya penurunan lingkup gerak sendi, atrofi, gangguan pernafasan, penurunan kemampuan fungsional, dan produksi sputum atau dahak berlebihan. Manajemen fisioterapi yang diberikan kepada pasien post craniotomy yang mengalami retensi sputum adalah chest fisioterapi, yaitu Deep Breathing Exercise, tapotement, vibration. Tujuannya untuk meningkatkan respirasi dan mengeluarkan sputum yang ada di dalam paru-paru akibat tirah baring. Intervensi lain yang diberikan yaitu pasif exercise yang dilakukan dengan tujuan mencegah terjadinya perlengketan jaringan dan memelihara elastisitas otot.
Tujuan: untuk mengetahui efektifitas chest fisioterapi, yaitu Deep Breathing Exercise, tapotement, vibration untuk mengurangi sesak napas dan mengeluarkan sputum pada pasien post craniotomy. Metode Penelitian : Studi yang dilakukan saat ini menggunakan single-subject research dengan pendekatan desain ABA. Hasil : adanya penurunan sesak napas yang diukur dengan borg scale dan adanya peningkatan kemampuan fungsional. Kesimpulan : Berdasarkan hasil penelitian menunjukkan bahwa chest fisioterapi ( deep breathing exercise, tapotement, vibration) efektif dalam mengurangi sesak napas dan mengeluarkan sputum pada pasien dengan kondisi post craniotomy.
Kata kunci : Craniotomy, Retensi Sputum, Chest Fisioterapi
PENATALAKSANAAN FISIOTERAPI PADA KASUS POST DOUBLY COMMITTED SUBARTERIAL VENTRICULAR SEPTAL DEFECTS CLOSURE:
Authors: Randa Meybi , Wijianto Wijianto , Susilo Ridwan Andi 
Published: January 2024

Pendahuluan: Subarterial doubly committed (SADC) merupakan subtipe VSD yang dikenal sebagai tipe VSD infundibular yang terletak di bawah katup semilunar (aorta dan pulmonal) di septum outlet ventrikel kanan diatas crista supraventricularis. Jenis VSD ini pada populasi Asia menyumbang sekitar 30% dibandingkan dengan populasi Barat (5-10%). Kelainan ini menyebabkan tidak mampunya katup menutup secara spontan dan prolaps katup aorta, serta regurgitasi aorta (AR) yang diperkirakan melebihi 40% akibat tidak adanya septum infundibular. Metode: Metode penelitian yang digunakan adalah case report dengan identitas seorang pria berusia 24 tahun terdiagnosa subarterial doubly committed pasca operasi VSD closure atau penutupan katup jantung yang akan mengikuti program rehabilitasi jantung di RSUD Moewardi Surakarta dengan jenis latihan aerobic sebanyak 3 kali pertemuan dan keluhan pasien sekarang adalah mudah lelah, serta intoleransi aktivitas. Hasil: Latihan pertama diperoleh METS 9,131 atau VO2Max 31,960, latihan kedua diperoleh METS 8,90 atau VO2Max 31,151 dan latihan ketiga 7,65 METS. Simpulan: Adanya pengaruh latihan aerobic terhadap proses penyembuhan pasca operasi VSD closure, tetapi terjadi penurunan kapasitas aerobic akibat latihan home program yang jarang dilakukan pasien.

Introduction: Subarterial double committed (SADC) is a subtype of VSD known as the infundibular VSD type which is located below the semilunar valves (aortic and pulmonary) in the right ventilation outlet septum above the supraventricular crista. This type of VSD in the Asian population accounts for about 30% compared to the Western population (5-10%). This condition causes the inability of the valve to close spontaneously and prolapse of the aortic valve, as well as aortic regurgitation (AR) which is estimated to exceed 40% due to the absence of an infundibular septum. Methods: The research method used was a case report with the identity of a 24-year-old man diagnosed with subarterial double commit after VSD closure surgery or heart valve closure who was going to take part in a cardiac rehabilitation program at the regional public hospital Moewardi Surakarta with a type of aerobic exercise for 3 meetings and the patient's complaints are now easily tired and activity intolerance. Results: The first exercise obtained METS 9.131 or VO2Max 31.960, the second exercise obtained METS 8.90 or VO2Max 31.151 and the third exercise 7.65 METS. Conclusion: There is an effect of aerobic exercise on the healing process after VSD closure surgery, but there is a decrease in aerobic capacity due to exercise programs at home which patients rarely do.
Intermediate site of development of Anaplasma marginale in feeding adult Dermacentor andersoni ticks that were infected as nymphs
Authors: Kocan Katherine M. , Stich Roger W. , Claypool P. L. , Ewing S. A. , Hair Jakie A. , Barron Selwyn J. 
Published: January 2024

SUMMARY
The development of Anaplasma marginale in midgut epithelial cells was studied in feeding, transmitting adult Dermacentor andersoni ticks. Laboratory-reared ticks experimentally infected as nymphs were allowed to feed from 1 to 9 days on susceptible calves. Gut tissues from ticks were collected on each day they fed (total, 9 days) and were processed for light and transmission electron microscopy. Colonies of A marginale were abundant during the first 6 days of feeding, after which numbers decreased. Colonies were adherent to the basement membrane of gut cells early during feeding, with resultant flattening of the colonies. Colonies also were seen in muscle cells on the hemocoel side of the basement membrane. Morphologic features of A marginale within muscle cells varied and were similar to those observed in gut cells. In addition, however, a large reticulated form in the colonies was observed in muscle cells and appeared to give rise to small particles by budding. Development of A marginale in muscle cells appears to represent an intermediate site of development between those in gut and in salivary glands.
Cardiopulmonary effects of position in conscious cattle
Authors: Wagner Ann E. , Muir William W. , Grospitch Beverly J. 
Published: January 2024

SUMMARY
The cardiopulmonary effects of 4 positions (standing, right lateral, left lateral, and dorsal recumbency) were evaluated in conscious cattle in which no sedatives or anesthetic drugs were given. Each position was maintained for 30 minutes, during which time there were no significant changes in heart rate, respiratory rate, mean arterial blood pressure, arterial pH, PaCO2, arterial base excess, or venous blood gas values. Significant decreases in PaO2 developed when cattle were in lateral positions and dorsal recumbency. Cardiac index was unchanged in all positions, except in dorsal recumbency at 30 minutes, when it was significantly decreased.
Disassociation of bactericidal and fungistatic activities from the oxidative burst of avian macrophages
Authors: Harmon Barry G. , Glisson John R. 
Published: January 2024

SUMMARY
Avian peritoneal exudate macrophages, when exposed to phagocytic stimuli, produced an appreciable oxidative burst as measured by production of chemiluminescence, superoxide anion, and hydrogen peroxide. Metabolic inhibitors of the oxidative burst and scavengers of oxygen radicals clearly inhibited macrophage chemiluminescence, but had no significant effect on macrophage bactericidal activity against Escherichia coli or fungistatic activity against Candida tropicalis. Therefore, avian macrophages were capable ofox ygen-independent bactericidal and fungistatic activities.
Early effects of ethylene glycol on the ultrastructure of the renal cortex in dogs
Authors: Smith B. J. , Anderson B. G. , Smith S. A. , Chew D. J. 
Published: January 2024

SUMMARY
A sublethal dose of ethylene glycol was administered orally to 3 groups of dogs; dogs of a control group were given distilled water instead. Renal cortical biopsy samples were obtained from dogs of experimental and control groups at various times after treatment. Tissue was examined by use of light microscopy and transmission electron microscopy. In dogs of the control group, the light and electron microscopic appearances of tissue were within normal limits at all sample collection hours. In dogs of the experimental groups, renal corpuscular structure remained within normal limits by use of light and electron microscopy throughout the study, though morphologic change was seen in other structures of the cortex. Light microscopic lesions first appeared at 12 hours, and were similar to those reported in the literature. Ultrastructural lesions were first observed in the 5-hour samples, and similar to the light microscopic lesions, were most common in the proximal convoluted tubules (pct). Initial pct cellular changes included vacuolization of cells and distention of the parabasal extracellular spaces; pct cellular lesions seen in later-hour samples included formation of apical buds and cellular rupture. Internalization or sloughing of the pct brush border was not observed. Distal convoluted tubules (dct) were frequently dilated and/or packed with cellular debris. A few dct cells had degenerative or necrotic changes. In pct and dct, abnormal cells were frequently flanked by normal or nearly normal cells. During later hours, a few cells with types of changes first observed in early hours continued to be observed, implying ongoing response of cells to the toxin.
Prevalence of four enterotoxin (STaP, STaH, STb, and LT) and four adhesin subunit (K99, K88, 987P, and F41) genes among Escherichia coli isolates from cattle
Authors: Mainil Jacques G. , Bex Françoise , Jacquemin Etienne , Pohl Pierre , Couturier Martine , Kaeckenbeeck Albert 
Published: January 2024

SUMMARY
Colony hybridizations with DNA probes for 3 heat-stable (STap, STaH, and STb) enterotoxins and 1 heat-labile (LT) enterotoxin and for 4 adhesins (K99, F41, K88, 987P) were performed on 870 Escherichia coli isolates to determine pathotypes prevalent among enterotoxigenic E coli (ETEC) isolated form cattle in Belginum. One hundred thirty-two E coli isolates (15.2%) hybridized with probes STap, K99, and/or F41. The 5 other probes were not hybridized by E coli isolates. Therefore, only STaP enterotoxin and K99 and F41 adhesins were virulence factors of ETEC isolated from cattle. Two major pathotypes accounted for 95% of the ETEC: STaP+ K99+ F41+ (67.4%) and STaP+ K99+ (27.3%). The last 5% of probe-positive isolates had STaP+ STaP+ F41+, or K99+ F41+ minor pathotypes. Of 12 American ETEC isolates also assayed, 7 were positive with STb and/or 987P probes (pathotypes STap+ STb+ STaP+ 987P+, or STaP+STb+987P+) and may be porcine-rather than bovine-specific enteropathogens. The remaining 5 American ETEC isolates belonged to 3 minor pathotypes (STaP+, STaP+, F41+, and K99+ F41+) also found among Belgian E coli isolates. Such isolates may be derivatives of STaP+ K99+ F41+ or STaP+ K99+ etec after in vivo or in vitro loss of virulence genes and /or non-etec isolates, which have acquired virulence genes by in vivo transfer.
Optimization of the under-agarose assay of porcine neutrophil migration
Authors: Elliott Glenn S. , Rebar Alan H. , McCabe George P. , Alzola Carlos 
Published: January 2024

SUMMARY
Important procedural factors in the under-agarose assay for porcine neutrophil migration were identified, and optimal conditions were established. Three factors were tested: the concentration of zymosan-activated serum inoculated into the outer well; the number of neutrophils inoculated into the center well; and the time of incubation of the agarose plates. All factors had a significant (P < 0.0001, 0.0001, and 0.01, respectively) effect on the chemotactic index of porcine neutrophils. The optimal combination of these 3 factors was undiluted zymosan-activated serum as the chemoattractant, 8 × 105 neutrophils inoculated into the center well, and 5 hours of incubation. The assay was validated, using standard conditions, and the data were used to predict the number of pigs and/or repetitive assays needed to identify differences among experimental groups.
Quantitation of the hepatobiliary dynamics in clinically normal dogs by use of 99mTc-iminodiacetate excretory scintigraphy
Authors: van den Brom Walter E. , Rothuizen Jan 
Published: January 2024

SUMMARY
The hepatobiliary dynamics of a 99mTc-labeled derivative of iminodiacetate were investigated in 29 healthy dogs. A 2-compartment model proved to be adequate to describe the hepatic time-activity curve. Model-derived variables for the hepatic accumulation and the biliary excretion and transport were used as a reference for evaluation of a number of commonly used measurements directly derived from hepatic and biliary time-activity curves (graphic variables). The difference between t50(ex) and t95(ex), representing the moments when 50 and 95%, respectively, of the maximal count rate during the hepatic excretory phase were measured, proved to be an adequate graphic variable to quantitate biliary excretion. The use of other graphic variables to quantitate hepatobiliary functions seemed unjustified.
Pharmacokinetics of phenylbutazone given intravenously or orally in mature Holstein bulls
Authors: Williams R. Joel , Smith John A. , Boudinot F. Douglas , Knight Anthony P. 
Published: January 2024

SUMMARY
Six mature Holstein bulls were each given 10 mg of phenylbutazone (pbz)/kg of body weight, po. Of the 6 bulls, 3 were given 10 mg of pbz/kg by rapid iv administration 4 weeks later. Plasma concentration-vs-time data were analyzed, using nonlinear regression modeling (sum of exponential functions). The harmonic mean of the biologic half-life of pbz was 62.6 ± 12.9 hours after oral administration and 61.6 ± 7.2 hours after iv administration. The mean residence time was 94.61 ± 8.44 hours and 90.49 ± 8.93 hours for oral and iv administration, respectively. The mean total body clearance was 0.0015 ± 0.0003 L/h/kg, with the mean apparent volume of distribution 0.134 ± 0.021 L/kg. Mean bioavailability was 73 ± 2% after oral administration. Phenylbutazone was adequately absorbed from the gastrointestinal tract in bulls. The apparent volume of distribution was small, indicating that pbz distributed mainly into plasma and extracellular fluid. The total body clearance was also small, which accounted for the long half-life of pbz in bulls.
Pharmacokinetics of phenylbutazone in mature Holstein bulls: Steady-state kinetics after multiple oral dosing
Authors: Williams R. Joel , Boudinot F. Douglas , Smith John A. , Knight Anthony P. 
Published: January 2024

SUMMARY
Six mature Holstein bulls were given an 8-day course of phenylbutazone (pbz) orally (loading dose, 12 mg of pbz/kg of body weight and 7 maintenance doses of 6 mg of pbz/kg, q 24 h). Plasma concentration-vs-time data were analyzed, using nonlinear regression modeling. The harmonic mean ± pseudo-sd of the biologic half-life of pbz was 61.8 ± 12.8 hours. The arithmetic mean ± sem of the total body clearance and apparent volume of distribution were 0.0021 ± 0.0001 L/h/kg and 0.201 ± 0.009 L/kg, respectively. The predicted mean minimal plasma concentration of pbz with this dosage regimen was 75.06 ± 4.05 μg/ml.
The predicted minimal plasma drug concentration was compared with the observed minimal plasma drug concentration in another group of bulls treated with pbz for at least 60 days. Sixteen mature Holstein bulls were given approximately 6 mg of pbz/kg, po, daily for various musculoskeletal disorders. The mean observed minimal plasma concentration of pbz in the 16 bulls was 76.10 ± 2.04 μg/ ml, whereas the mean predicted minimal plasma concentration was 74.69 ± 3.10 μg/ml.
Dosages of 4 to 6 mg of pbz/kg, q 24 h, or 10 to 14 mg of pbz/kg, q 48 h, provided therapeutic plasma concentrations of pbz with minimal steady-state concentrations between 50 and 70 μg/ml.