bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Erythrocyte‐Templated Iron Single‐Atom Nanozyme for Wound Healing
Authors: Wang Xiaonan , Liu Ting , Chen Mengxia , Liang Qian , Jiang Jing , Chen Lei , Fan Kelong , Zhang Jinhua , Gao Lizeng 
Published: December 2023

AbstractIron single‐atom nanozymes represent a promising artificial enzyme with superior activity owing to uniform active sites that can precisely mimic active center of nature enzymes. However, current synthetic strategies are hard to guarantee each active site at single‐atom state. In this work, an erythrocyte‐templated strategy by utilizing intrinsic hemin active center of hemoglobin as sing‐atom source for nanozyme formation is developed. By combining cell fixation, porous salinization, and high‐temperature carbonization, erythrocytes are successfully served as uniform templates to synthesize nanozymes with fully single‐atom FeN4 active sites which derived from hemin of hemoglobin, resulting in an enhanced peroxidase (POD)‐like activity. Interestingly, the catalytic activity of erythrocyte‐templated nanozyme (ETN) shows dependence on animal species, among which murine ETN performed superior catalytic efficiency. In addition, the as‐prepared ETNs display a honeycomb‐like network structure, serving as a sponge to accelerate hemostasis based on the interactions with prothrombin and fibrinogen. These features enable ETN to effectively kill methicillin‐resistant Staphylococcus aureus (MRSA) by combining POD‐like catalysis with near‐infrared (NIR) induced photothermal effect, and subsequently suitable to promote wound healing. This study provides a proof‐of‐concept for facile fabrication of multifunctional nanozymes with uniform single‐atom active sites by utilizing intrinsic iron structure characteristics of biogenic source like erythrocytes.
Multimolecular Competition Effect as a Modulator of Protein Localization and Biochemical Networks in Cell‐Size Space
Authors: Nishikawa Saki , Sato Gaku , Takada Sakura , Kohyama Shunshi , Honda Gen , Yanagisawa Miho , Hori Yutaka , Doi Nobuhide , Yoshinaga Natsuhiko , Fujiwara Kei 
Published: December 2023

AbstractCells are small, closed spaces filled with various types of macromolecules. Although it is shown that the characteristics of biochemical reactions in vitro are quite different from those in living cells, the role of the co‐existence of various macromolecules in cell‐size space remains still elusive. Here, using a constructive approach, it is demonstrated that the co‐existence of various macromolecules themselves has the ability to tune protein localization for spatiotemporal regulation and a biochemical reaction system in a cell‐size space. Both experimental and theoretical analyses reveal that enhancement of interfacial effects by a large surface‐area‐to‐volume ratio facilitates membrane localization of molecules in the cell‐size space, and the interfacial effects are alleviated by competitive binding to lipid membranes among multiple proteins even if their membrane affinities are weak. These results indicate that competition for membrane binding among various macromolecules in the cell‐size space plays a role in regulating the spatiotemporal molecular organization and biochemical reaction networks. These findings shed light on the importance of surrounding molecules for biochemical reactions using purified elements in small spaces.
Nanoscale Reconfigurable Si Transistors: From Wires to Sheets and Unto Multi‐Wire Channels
Authors: Wind Lukas , Behrle Raphael , den Hertog Martien I. , Murphey Corban G. E. , Cahoon James F. , Sistani Masiar , Weber Walter M. 
Published: December 2023

AbstractIn this work, bottom‐up Al–Si–Al nanowire (NW) heterostructures are presented, which act as a prototype vehicle toward top‐down fabricated nanosheet (NS) and multi‐wire (MW) reconfigurable field‐effect transistors (RFETs). Evaluating the key parameters of these transistors regarding the on‐ and off‐currents as well as threshold voltages for n‐ and p‐type operation exhibit a high degree of symmetry. Most notably also a low device‐to‐device variability is achieved. In this respect, the investigated Al–Si material system reveals its relevance for reconfigurable logic cells obtained from Si NSs. To show the versatility of the proposed devices, this work reports on a combinational wired‐AND gate obtained from a multi‐gate RFET. Additionally, up‐scaling the current is achieved by realizing a MW RFET without compromising reconfigurability. The Al–Si–Al platform has substantial potential to enable complex adaptive and self‐learning combinational and sequential circuits with energy efficient and small footprint computing paradigms as well as for native components for hardware security circuits.
Wide‐Bandgap Nickel Oxide with Tunable Acceptor Concentration for Multidimensional Power Devices
Authors: Ma Yunwei , Qin Yuan , Porter Matthew , Spencer Joseph , Du Zhonghao , Xiao Ming , Wang Boyan , Wang Yifan , Jacobs Alan G. , Wang Han , Tadjer Marko , Zhang Yuhao 
Published: December 2023

AbstractMultidimensional power devices can achieve performance beyond conventional limits by deploying charge‐balanced p‐n junctions. A key obstacle to developing such devices in many wide‐bandgap (WBG) and ultra‐wide bandgap (UWBG) semiconductors is the difficulty of native p‐type doping. Here the WBG nickel oxide (NiO) as an alternative p‐type material is investigated. The acceptor concentration (NA) in NiO is modulated by oxygen partial pressure during magnetron sputtering and characterized using a p‐n+ heterojunction diode fabricated on gallium oxide (Ga2O3) substrate. Capacitance and breakdown measurements reveal a tunable NA from < 1018 cm−3 to 2×1018 cm−3 with the practical breakdown field (EB) of 3.8 to 6.3 MV cm−1. This NA range allows for charge balance to n‐type region with reasonable process latitude, and EB is high enough to pair with many WBG and UWBG semiconductors. The extracted NA is then used to design a multidimensional Ga2O3 diode with NiO field‐modulation structure. The diodes fabricated with two different NA both achieve 8000 V breakdown voltage and 4.7 MV cm−1 average electric field. This field is over three times higher than the best report in prior multi‐kilovolt lateral devices. These results show the promise of p‐type NiO for pushing the performance limits of power devices.
Multilayer Superlattices of Monolayer Mesoporous Carbon Framework‐Intercalated MXene for Efficient Capacitive Energy Storage
Authors: Huang Xianwu , Lyu Xuanyu , Wu Guanhong , Yang Jing , Zhu Run , Tang Yi , Li Tongtao , Wang Yajun , Yang Dong , Dong Angang 
Published: December 2023

AbstractIncorporating conductive and porous components as pillaring materials into the interlayers of two‐dimensional (2D) materials offers a solution to the restacking issue and enables the creation of multifunctional hetero‐superstructures. Here, multilayer MXene superlattices intercalated with monolayer mesoporous carbon frameworks (MMCFs) are synthesized by colloidal co‐assembly of MXene Ti3C2Tx nanosheets and Fe3O4 nanoparticles. The intercalated MMCFs not only increase interlayer spacing and create porous channels for fast mass transport but also act as conductive pillars to facilitate electron transfer along the z‐direction. These unique structural features allow for the full utilization of unilamellar MXene, making the resulting Ti3C2Tx/MMCF superlattices particularly suitable for capacitive energy storage in organic electrolytes containing bulky ions. As a demonstration, supercapacitors made from Ti3C2Tx/MMCFs exhibit a volumetric capacitance of 317 F cm−3 in a tetraethylammonium tetrafluoroborate/propylene carbonate electrolyte. Furthermore, on‐chip micro‐supercapacitors (MSCs) fabricated from Ti3C2Tx/MMCFs, using the ionic liquid 1‐ethyl‐3‐methylimidazolium tetrafluoroborate as an electrolyte, achieve an areal energy density of 0.10 mWh cm−2, surpassing that of most state‐of‐the‐art MXene‐based MSCs developed to date. This study not only highlights the significant potential of Ti3C2Tx/MMCFs for efficient capacitive energy storage in organic electrolytes but also introduces a new method for synthesizing 2D porous hetero‐superstructures for various applications.
Mechanistic Understanding of Additive Reductive Degradation and SEI Formation in High‐Voltage NMC811||SiOx‐Containing Cells via Operando ATR‐FTIR Spectroscopy
Authors: Weiling Matthias , Lechtenfeld Christian , Pfeiffer Felix , Frankenstein Lars , Diddens Diddo , Wang Jian‐Fen , Nowak Sascha , Baghernejad Masoud 
Published: December 2023

AbstractThe implementation of silicon (Si)‐containing negative electrodes is widely discussed as an approach to increase the specific capacity of lithium‐ion batteries. However, challenges caused by severe volume changes and continuous (re‐)formation of the solid‐electrolyte interphase (SEI) on Si need to be overcome. The volume changes lead to electrolyte consumption and active lithium loss, decaying the cell performance and cycle life. Herein, the additive 2‐sulfobenzoic acid anhydride (2‐SBA) is utilized as an SEI‐forming electrolyte additive for SiOx‐containing anodes. The addition of 2‐SBA to a state‐of‐the‐art carbonate‐based electrolyte in high‐voltage LiNi0.8Mn0.1Co0.1O2, NMC811||artificial graphite +20% SiOx pouch cells leads to improved electrochemical performance, resulting in a doubled cell cycle life. The origin of the enhanced cell performance is mechanistically investigated by developing an advanced experimental technique based on operando attenuated total reflection Fourier‐transform infrared (ATR‐FTIR) spectroscopy. The operando ATR‐FTIR spectroscopy results elucidate the degradation mechanism via anhydride ring‐opening reactions after electrochemical reduction on the anode surface. Additionally, ion chromatography conductivity detection mass spectrometry, scanning electron microscopy, energy dispersive X‐ray analysis, and quantum chemistry calculations are employed to further elucidate the working mechanisms of the additive and its degradation products.
Adequate gross resection margin length ensuring pathologically complete resection in gastrectomy for gastric cancer: A systematic review and meta‐analysis
Authors: Hayami Masaru , Ohashi Manabu , Kurihara Nozomi , Nunobe Souya 
Published: December 2023

AbstractAimA positive resection margin (RM) is associated with poor survival after gastrectomy for gastric cancer (GC). However, the adequate RM length to avoid a positive RM remains controversial. We performed a systematic review to examine the RM length required to avoid a positive RM in gastrectomy for GC.MethodsThis systematic review involved all relevant articles identified in PubMed, the Cochrane Library, Web of Science, and ClinicalTrials.gov until August 2023. The incidence of a positive RM related to the RM length and the possible incidence of a positive RM estimated from the discrepancy between the gross and pathological RM length were evaluated. The Newcastle–Ottawa Scale was used to quantify study quality.ResultsThirteen studies involving 8983 patients were analyzed. Investigation of the incidence of a positive RM in relation to the RM length showed that a proximal RM length of 6 cm guaranteed a negative RM in gastrectomy. Analyses of the possible incidence of a positive RM revealed that a negative RM would be guaranteed if the proximal RM length was 6 cm in distal gastrectomy, if the esophageal resection length was 2 cm in total gastrectomy for GC without esophageal invasion and 2.5 cm in total or proximal gastrectomy for GC with esophageal invasion or esophagogastric junction cancer, and if the distal RM length was 4 cm in proximal gastrectomy for early GC.ConclusionsThe adequate RM lengths to ensure a pathologically negative RM in each type of gastrectomy for GC were herein suggested.
Li‐ion hopping conduction enabled by associative Li‐salt in acetonitrile solutions
Authors: Koo Bonhyeop , Lee Hyejin , Park Kisung , Hwang Sunwook , Lee Hochun 
Published: December 2023

AbstractTo date, ionic conduction in nonaqueous electrolytes has been explained through the vehicle‐type migration mechanism. Yet, new research hints at another conduction mode: ion‐hopping, seen in highly concentrated solutions with multi‐coordinating solvents. Our research uncovers that Li‐ion hopping conduction also occurs in monodentate acetonitrile (AN) electrolytes, enabled by a highly associative Li‐salt. Using techniques like pulse‐field gradient NMR, Raman spectroscopy, and dielectric relaxation spectroscopy, we examined AN solutions with lithium trifluoroacetate (LiTFA) and lithium bis(fluorosulfonyl)imide (LiFSI). Results showed that Li‐ion diffusion in LiTFA‐AN was faster due to an anion‐bridge structure formed by the associative nature of LiTFA. In contrast, the LiFSI‐AN solution demonstrated slower Li‐ion movement. In practical applications, like LiFePO4 symmetric cells, 4 M LiTFA‐AN outperformed 1 M LiTFA‐AN in rate performance, despite its lower ionic conductivity. This challenges the belief that associative Li‐salts are unsuitable for battery electrolytes and prompts reconsideration of other associative Li‐salts.
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft‐versus‐host disease
Authors: Qi Ling , Peng Jie , Huang Xianbao , Zhou Ting , Tan Genmei , Li Fei 
Published: December 2023

AbstractAimThe gut microbiota has been reported to be associated with acute graft‐versus‐host disease (aGvHD) in hematopoietic stem cell transplantation (HSCT). Dynamic surveillance of the microbiota is required to understand the detailed pathogenesis involved in the process of aGvHD.MethodsFecal samples were collected prospectively at four timepoints, including pre‐HSCT (T1), graft infusion (T2), neutrophil engraftment (T3), and 30 days after transplantation (T4). Fecal samples were profiled by 16S ribosomal RNA gene sequencing to assess the microbiota composition.ResultsFrom the T1 to T4 timepoint, the diversity of the gut microbiota decreased, and the dominant species also changed, with a decrease in the obligate anaerobic bacteria and a shift toward a “pathogenic community”. Compared with non‐aGvHD patients, aGvHD patients had a lower abundance of Roseburia at T1 and a higher abundance of Acinetobacter johnsonii at T2. Furthermore, Acinetobacter johnsonii was negatively correlated with the secretion of IL‐4 and TNF‐α. At T3, Rothia mucilaginos was demonstrated to be linked with a decreased risk of aGvHD, which was accompanied by decreased secretion of IL‐8. At T4, higher abundances of Lactobacillus paracasei and Acinetobacter johnsonii were identified to be related with aGvHD. Lactobacillus paracasei was associated with the downregulation of IL‐10, and Acinetobacter johnsonii was associated with the downregulation of IL‐2 and TNF‐α.ConclusionsDynamic changes in gut microbiota composition and related cytokines were found to be related to aGvHD, including pathogenic or protective changes. These findings suggested that manipulation of gut microbiota at different timepoints might be a promising avenue for preventing or treating this common complication.
Five‐year follow‐up after percutaneous pulmonary valve implantation using the Venus P‐valve system for patients with pulmonary regurgitation and an enlarged native right ventricular outflow tract
Authors: Jin Qinchun , Long Yuliang , Zhang Gejun , Pan Xin , Chen Mao , Feng Yuan , Liu Jinfen , Yu Shiqiang , Pan Wenzhi , Zhou Daxin , Ge Junbo 
Published: December 2023

AbstractBackgroundPercutaneous pulmonary valve implantation (PPVI) with the self‐expandable Venus P‐valve system is a promising treatment for patients with pulmonary regurgitation (PR) and a native right ventricular outflow tract (RVOT). However, limited data is available regarding its midterm outcomes. This study assessed the midterm clinical and echocardiographic outcomes following Venus P‐valve implantation.MethodsFrom 2013 to 2018, 55 patients with moderate or severe PR after surgical RVOT repair with a transannular or RVOT patch were consecutively enrolled from six hospitals in China. Five‐year clinical and echocardiographic outcomes were collected and evaluated. The primary endpoint was a freedom from all‐cause mortality and reintervention.ResultsAt 5 years, the primary endpoint was met for 96% of patients, corresponding to a freedom from all‐cause mortality of 96% (95% confidence interval [CI]: 86%−99%) and freedom from reintervention of 98% (95% CI: 87%−100%). Endocarditis was reported in five patients (four patients within 1 year and one patient at 5 years) following PPVI. Transpulmonary gradient and stent orifice diameter remained stable compared to at discharge (p＞0.05). No paravalvular leak was reported while only 1 patient gradually increased to moderate PR during follow‐up. Significant improvement of RV diameter and LVEF (p＜0.001) sustained over the 5‐year follow‐up, in consistent with remarked improved New York Heart Association(NYHA) functional class (p＜0.001).ConclusionThe 5‐year results of the China VenusP Study demonstrated the midterm benefits of Venus P‐valve implantation in the management of patients with severe PR with an enlarged native RVOT by providing sustained symptomatic and hemodynamic improvement.
Extralobar pulmonary sequestration: A case report and literature review
Authors: Wang Tao , Zhao Zonglei , Kong Lingqun , Lyu Xiaoqin , Cao Xuefeng , Zhang Xingyuan , Chen Qiangpu 
Published: December 2023

Key Clinical MessagePulmonary sequestration is a congenital malformation of lung development in which part of the lung tissue is separated from the normal lung during the embryonic phase and develops separately and receives blood supply from an aberrant systemic artery forming a nonrespiratory mass. In brief, early in embryonic development, certain tissues that should have atrophied and been gradually absorbed are left behind due to impairment of the atrophy process and form anomalous branches of the aorta, which pull parts of the lung tissue, isolating them from normal lung tissue and bronchi, and thus forming separate lung tissue. According to the relationship of the mass to the pleural covering, pulmonary sequestration can be divided into two types, intralobar pulmonary sequestration (ILS) and extralobar pulmonary sequestration (ELS), of which approximately 75% of cases are ILS, but ELS is less common. Symptoms are not obvious in either type, making diagnosis and differential diagnosis more difficult. Here we report a 33‐year‐old patient with only insignificant abdominal distension who was eventually diagnosed with retroperitoneal ELS.
Practical Synthesis of Valbenazine via 1,3‐Dipolar Cycloaddition†
Authors: Peng Yalan , Lin Zuming , Zhu Lili , Han Shiqing , Huang Sha‐Hua , Hong Ran 
Published: December 2023

Comprehensive SummaryValbenazine (Ingrezza), a potent and highly selective inhibitor of vesicular monoamine transporter type 2 (VMAT2) through the active metabolite hydrotetrabenazine (HTBZ), has been approved for the treatment of tardive dyskinesia and, very recently, for chorea, which is associated with Huntington's disease. Despite numerous synthetic efforts dedicated to the synthesis of HTBZ, the industrial preparation of valbenazine uses dihydroisoquinoline as a starting material and the chiral resolution of racemic HTBZ derived from ketone reduction. Herein, we present a practical synthesis of HTBZ and valbenazine featuring a highly stereoselective 1,3‐dipolar cycloaddition and enzymatic kinetic resolution. The cascade process includes cycloaddition, N—O bond cleavage, and lactamization, which proved to be operationally simple. The allure of the enzymatic resolution developed in this work offers a rapid access toward affording tetrahydroisoquinoline (THIQ)‐fused piperidine in the production of medically significant compounds, such as yohimbine and reserpine.
Reproductive outcomes and reproductive health care utilization among male survivors of childhood cancer: A DCCSS‐LATER study
Authors: Claessens Joyce J. M. , Penson Adriaan , Bronkhorst Ewald M. , Kremer Leontien C. M. , van Dulmen‐den Broeder Eline , van der Heiden‐van der Loo Margriet , Tissing Wim J. E. , van der Pal Helena J. H. , Blijlevens Nicole M. A. , van den Heuvel‐Eibrink Marry M. , Versluys A. Birgitta , Bresters Dorine , Ronckers Cécile M. , Walraven Iris , Beerendonk Catharina C. M. , Loonen Jacqueline J. ,   for the Dutch LATER study group
Published: December 2023

AbstractBackgroundTreatment‐related gonadal dysfunction leading to fertility problems is a frequently encountered late effect in childhood cancer survivors (CCSs). This study evaluated reproductive outcomes and reproductive health care utilization among male CCSs compared with male siblings.MethodsA nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor LATER study part 1, a questionnaire and linkage study. A questionnaire addressing reproductive outcomes and reproductive health care was completed by 1317 male CCSs and 407 male siblings. A total of 491 CCSs and 185 siblings had a previous or current desire for children and were included in this study.ResultsFewer CCSs had biological children compared with siblings (65% vs. 88%; p < .001). The type of conception by men who fathered a child was comparable between CCSs and siblings (spontaneous conception of 90% of both groups; p = .86). The percentage of men who had consulted a reproductive specialist because of not siring a pregnancy was higher in CCSs compared with siblings (34% vs. 12%; p < .001). Following consultation, fewer CCSs underwent assisted reproductive techniques (ART) compared with siblings (41% vs. 77%; p = .001). After ART, fewer CCSs fathered a child compared with siblings (49% vs. 94%; p = .001).ConclusionsMore male survivors consult a reproductive specialist, but fewer survivors undergo ART and father a child after ART compared with siblings. This insight is important for understanding potential problems faced by survivors regarding family planning and emphasizes the importance of collaboration between oncologists and reproductive specialists.
Grounded synthetic series lossy inductor simulator circuits employing single current differencing buffered amplifier
Authors: Bhaskar Data Ram , Bhagat Ram , Raj Ajishek , Kumar Pragati 
Published: December 2023

SummaryIn this communication, two new positive lossy series inductor simulator circuits using single current differencing buffered amplifier (CDBA), one capacitor, and three resistors are presented. In both the proposed circuits, the inductance value is independently controllable through a grounded resistor, which may be implemented using a voltage‐controlled resistor (VCR), facilitating electronic tuning. Moreover, one of the circuits presented utilizes the intrinsic resistance (internal resistance available at input ports p and n) of the CDBA, thereby enabling electronic control and establishing the inductor simulator as canonical. Both the circuits are analyzed for non‐ideal behavior by taking into account the parasitic elements of CDBA and compared with their ideal counterparts. To demonstrate the efficacy of the proposed series RL simulator circuits, SPICE simulations are performed using CMOS CDBA, and the performance of the proposed circuits is evaluated by designing a lead compensator. The simulation and experimental results of the proposed circuits, along with the application examples employing CDBA realized with the off‐the‐shelf available IC AD844, have also been corroborated.