bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbodiimide and Isocyanate Hydroboration by a Cyclic Carbodiphosphorane Catalyst**
Authors: Janda Ben A. , Tran Julie A. , Chang Daniel K. , Nerhood Gabriela C. , Maduka Ogba O. , Liberman‐Martin Allegra L. 
Published: October 2023

AbstractWe report hydroboration of carbodiimide and isocyanate substrates catalyzed by a cyclic carbodiphosphorane catalyst. The cyclic carbodiphosphorane outperformed the other Lewis basic carbon species tested, including other zerovalent carbon compounds, phosphorus ylides, an N‐heterocyclic carbene, and an N‐heterocyclic olefin. Hydroborations of seven carbodiimides and nine isocyanates were performed at room temperature to form N‐boryl formamidine and N‐boryl formamide products. Intermolecular competition experiments demonstrated the selective hydroboration of alkyl isocyanates over carbodiimide and ketone substrates. DFT calculations support a proposed mechanism involving activation of pinacolborane by the carbodiphosphorane catalyst, followed by hydride transfer and B−N bond formation.
Study on Structures Stability, Mechanical Properties, and Electronic Properties of Alloy Ag–Au–Al: First‐Principles Calculations and Experiments
Authors: Han Xujin , Liu Manmen , Zhou Xiaolong 
Published: October 2023

AbstractIn this paper, the silver–gold–aluminum alloy is prepared, and its effect on the microstructure and properties is observed by changing the content of aluminum. SEM observes the surface morphology, EDS (Energy Dispersive Spectrometer) detects the related tissue composition, and XRD (X‐ray Diffraction) verifies the composition. Ternary alloys are tested for hardness and resistivity. The results show that Ag‐15wt.%Au‐14wt.%Al alloy has the highest hardness. The resistivity test shows that Ag‐15wt.%Au‐18wt.%Al alloy has the lowest resistivity. The change in Al content improves the alloy's mechanical properties and electrical conductivity. This paper uses the first‐principles calculation based on density functional theory to prove the structural stability from the atomic point of view. The mechanical properties, electrical properties, and thermodynamic properties of Ag‐Au‐Al ternary alloys are systematically studied, including elastic constants, elastic modulus (including bulk modulusB, shear modulusG, Young's modulusE, Poisson's ratioν), Vickers hardness. The mechanical properties of the single crystal are evaluated by Cauchy pressure, Pugh criterion, shear anisotropy factor, and directional Young's modulus, and the Debye temperature is calculated. The calculation results are in good agreement with the experiment. The research in this paper provides a new idea for studying the properties of new bonding wires.
Have corporate social responsibility strategies mattered during the pandemic: Symbolic CSR versus substantive CSR
Authors: Khanchel Imen , Lassoued Naima , Gargouri Rym 
Published: October 2023

AbstractThis paper contributes to the existing CSR decoupling literature by examining whether the COVID‐19 pandemic increased the likelihood of firms adopting a corporate social responsibility (CSR) decoupling strategy and by assessing the impact of a symbolic CSR strategy on abnormal returns. The study analyzes a sample of 75 socially responsible French‐listed firms. The findings indicate that symbolic CSR reporting strategies were more likely to be implemented in response to the COVID‐19 crisis. Furthermore, while the market initially rewarded greenwashing practices during the COVID‐19 crisis in the short term, it subsequently penalized such practices over the long term. Additionally, abnormal returns of firms operating in the most severely affected industries surpassed those of firms in the least affected industries. Finally, the results highlight that firms adopting a defensive CSR strategy during the health crisis experienced more significant abnormal returns compared to other firms.
Electrochemical Sodium Storage in Hard Carbon Powder Electrodes Implemented in an Improved Cell Assembly: Insights from In‐Situ and Ex‐Situ Solid‐State NMR
Authors: Šić Edina , Schutjajew Konstantin , Haagen Ulrich , Breitzke Hergen , Oschatz Martin , Buntkowsky Gerd , Gutmann Torsten 
Published: October 2023

AbstractIn this work, we report on an improved cell assembly of cylindrical electrochemical cells for 23Na in‐situ solid‐state NMR (ssNMR) investigations. The cell set‐up is suitable for using powder electrode materials. Reproducibility of our cell assembly is analyzed by preparing two cells containing hard carbon (HC) powder as working electrode and sodium metal as reference electrode. Electrochemical storage properties of HC powder electrode derived from carbonization of sustainable cellulose are studied by ssNMR. 23Na in‐situ ssNMR monitors the sodiation/desodiation of a Na|NaPF6|HC cell (cell 1) over a period of 22 days, showing high cell stability. After the galvanostatic process, the HC powder material is investigated by high resolution 23Na ex‐situ MAS NMR. The formation of ionic sodium species in different chemical environments is obtained. Subsequently, a second Na|NaPF6|HC cell (cell 2) is sodiated for 11 days achieving a capacity of 220 mAh/g. 23Na ex‐situ MAS NMR measurements of the HC powder material extracted from this cell clearly indicate the presence of quasi‐metallic sodium species next to ionic sodium species. This observation of quasi‐metallic sodium species is discussed in terms of the achieved capacity of the cell as well as of side reactions of sodium in this electrode material.
A novel compact and tunable positive and negative impedance simulator and multiplier
Authors: Al‐Absi Muneer A. 
Published: October 2023

SummaryThis paper presents a novel CMOS tunable positive and negative active inductor simulator (AIS), positive capacitance and resistance multiplier, and negative capacitance and resistance simulator. The proposed designs use only one analog building block (ABB), one grounded capacitor, and two resistors. Applications to the proposed designs in different types of tunable filters and parasitic compensation schemes are also presented. The functionality of the designs is confirmed using Tanner Tspice in 0.18 μm TSMC CMOS technology. Simulation results indicate that the proposed designs are superior to previous arts in number of ABB, number of functions, and power consumptions.
Clinical and biological significance of circulating miRNAs in chronic pancreatitis patients undergoing total pancreatectomy with islet autotransplantation
Authors: Vasu Srividya , Saracino Giovanna , Darden Carly M. , Kumano Kenjiro , Liu Yang , Lawrence Michael C. , Naziruddin Bashoo 
Published: October 2023

AbstractBackgroundSpecific microRNAs (miRNAs) were elevated in chronic pancreatitis (CP) patients during islet infusion after total pancreatectomy (TPIAT). We aimed to identify circulating miRNA signatures of pancreatic damage, predict miRNA‐mRNA networks to identify potential links to CP pathogenesis and identify islet isolation and transplantation functional outcomes.MethodsSmall RNA sequencing was performed to identify distinct circulating miRNA signatures in CP. Plasma miRNAs were measured using miRCURY LNA SYBR green quantitative real‐time polymerase chain reaction assays. Correlation analyses were performed using R software. The miRNA target and disease interactions were determined using miRNet and the miRNA enrichment and annotation tool.ResultsAlterations were found in circulating miRNAs in CP patients compared to healthy controls. Further studies were conducted on 12 circulating miRNAs enriched in the pancreas, other tissues and other diseases including cancer and fibrosis. Approximately 2888 mRNAs in the pancreas were their targets, demonstrating interactions with 76 small molecules. Three miRNAs exhibited interactions with morphine and five exhibited interactions with glucose. The miRNA panel targeted 22 genes associated with pancreatitis. The islet‐specific, acinar cell‐specific and liver‐specific miRNAs were elevated at 6 h after islet infusion and returned to baseline levels 3 months after TPIAT. Circulating levels of miRNAs returned to pre‐transplant levels 1‐year post‐transplant. Circulating miRNAs measured before and 6 h after islet infusion were directly or inversely associated with metabolic outcomes at 3 and 6 months post‐transplant.ConclusionsmiRNAs may contribute to CP pathogenesis, and elevated circulating levels may be specific to pancreatic inflammation and fibrosis, warranting further investigation.
Single‐cell RNA sequencing analysis reveals transcriptional heterogeneity of multiple primary lung cancer
Authors: Guo Wei , Zhou Bolun , Bie Fenglong , Huai Qilin , Xue Xuemin , Guo Lei , Tan Fengwei , Xue Qi , Zhao Liang , Gao Shugeng 
Published: October 2023

AbstractIntroductionWith the advancements in early diagnosis, more and more patients with multiple primary lung cancer (MPLC) have been identified. However, the progression of MPLC involves complex changes in cell composition and metabolic function, which remains largely controversial.ObjectiveOur study aims to comprehensively reveal the cellular characteristics and inter‐cellular connections of MPLC.MethodsWe performed scRNA‐seq from 23 samples of six MPLC patients, combined with bulk whole‐exome sequencing. We performed trajectory analysis to investigate the transition of different cell types during the development of MPLC.ResultsA total of 1 67 397 cells were sequenced derived from tumour and adjacent tissues of MPLC patients, and tumour, normal, immune and stromal cells were identified. Two states of epithelial cells were identified, which were associated with immune response and cell death, respectively. Furthermore, both CD8+ naïve and memory T cells participated in the differentiation of CD8+ T cells. The terminal states of CD8+ T cells were exhausted T cells and cytotoxic T cells, which positively regulated cell death and were implicated in the regulation of cytokine production, respectively. Two main subpopulations of B cells with distinct functions were identified, which participate in the regulation of the immune response and antigen presentation, respectively. In addition, we found a specific type of endothelial cells that were abundant in tumour samples, with an increasing trend from normal to tumour samples.ConclusionsOur study showed the comprehensive landscape of different cells of MPLC, which might reveal the key cellular mechanisms and, therefore, may provide new insights into the early diagnosis and treatment of MPLC.
WntA and Wnt4 during the regeneration of internal organs in the holothurian Eupentacta fraudatrix
Authors: Girich A. S. 
Published: October 2023

SummaryBackgroundOver the past few years, it has been established that wnt genes are involved in the regenerative processes of holothurians. The wnt4 gene was identified as one of the most active genes in Eupentacta fraudatrix regeneration using differential gene expression analysis and qPCR of individual genes. Also, the wntA gene was found in holothurians, which is present only in invertebrates and can perform unique functions.ResultsIn this regard, both these genes and proteins were studied in this work. During regeneration, the Wnt4 protein is found in the cells of the coelomic and ambulacral epithelium, retractor muscles, and radial nerves. Single cells with this protein are also found in the connective tissue of the developing aquapharyngeal bulb and in the hypoderm of the body wall. Cells with WntA are found exclusively in the hypoderm of the body wall.ConclusionWe assume that both genes are involved in regeneration, but Wnt4 coordinates the formation of the epithelial tissue structure, while WntA maintains the state of the intercellular substance of the body wall.
Integration of environmental DNA metabarcoding technique to reinforce fish biodiversity assessments in seagrass ecosystems: A case study of Gazi bay seagrass meadows
Authors: Mwamburi Samuel Mwakisha , Uku Jacqueline , Wambiji Nina , Kairo James , Oketch Fredrick , Oduor Kennedy Omondi , Amondi Laureen , Ishmael Nimrod 
Published: October 2023

AbstractAssessing biodiversity in marine nearshore ecosystems is crucial for effective management, especially in the context of climate change and overexploitation of marine resources. Conventional methods often fall short in providing comprehensive information for managing seagrass ecosystems. However, the emergence of environmental DNA (eDNA) techniques has transformed the field by enabling noninvasive surveys that are cost effective and provide detailed information with high resolution. In this study, we utilized eDNA to assess fish diversity and compared its effectiveness to conventional techniques such as catch assessment surveys and underwater surveys. We sampled three habitats (A: mangrove‐seagrass, B: seagrass only, and C: coral‐seagrass) with 4 replicates. Site A recorded 8 fish species, site B had 16 species, and site C, characterized by coral and seagrass habitats, exhibited the highest fish diversity with 45 species (mean H′ index = 2.455), underscoring its ecological importance. To ensure accurate taxonomic identification, we utilized an updated MiFish reference database containing a larger number of fish species compared to the initial library. This expanded reference database with 9569 fish species, facilitated more precise identification and enhanced the reliability of our findings. Notably, the eDNA technique outperformed conventional methods by detecting 23 additional fish species that went undetected using traditional surveys. Moreover, our study documented five fish species previously unknown to occur within the study region, further emphasizing the value of eDNA analysis in uncovering hidden biodiversity. These findings strongly advocate for integrating eDNA techniques into the monitoring and assessment of biodiversity in shallow tropical habitats of the Western Indian Ocean. By leveraging eDNA surveys, we can gain valuable insights into fish diversity, discover hidden species, and make informed decisions for the conservation and management of these ecologically significant areas.
Prospective cohort study assessing patient satisfaction and diagnostic accuracy in channeled endoscope local anesthetic biopsy in the investigation of head and neck cancer
Authors: Lim Alison E. , Rogers Alexander D. G. , Montgomery Jenny 
Published: October 2023

AbstractBackgroundThere are delays in the head and neck Urgent Suspicion of Cancer (USOC) pathway. Local anesthetic (LA) biopsy with channeled endoscopes in outpatients can reduce time to diagnosis.MethodsQuestionnaire‐based prospective study of LA or general anesthetic (GA) biopsy for investigation of cancer from September 2021 to July 2022.Results100% (n = 48) were very satisfied or satisfied with their overall experience. 71% (n = 20) of LA patients reported they would prefer to have a biopsy under LA. LA biopsy was 68% sensitive and 100% specific for cancer diagnosis. 28.6% (8) and 10% (2) of LA and GA patients had palliative MDT outcomes. Median time to diagnosis was 44.5 and 49.0 days for LA and GA biopsy, respectively.ConclusionLA biopsy had a high satisfaction rate and is sensitive for diagnosing cancer. LA biopsy can expedite treatment pathways. LA biopsy should be considered as an option for first line investigation.
Comparative evaluation of fetal renal artery hemodynamics in normohydramnios, idiopathic oligohydramnios and polyhydramnios in third trimester pregnancy
Authors: Jain Deepak , Kumar Singh Rajesh , Jaiswal Jyoti , Mittal Pranjali , Singh Netam Satyabhuwan 
Published: October 2023

AbstractObjectiveTo compare the renal artery (RA) flow indices (RI and PI) among normohydramnios, idiopathic oligohydramnios, and polyhydramnios and determine applicability of fetal RA Doppler indices in predicting the pregnancy outcome.MethodsTotal 106 3rd trimester pregnant patients were divided into cases and controls based on amniotic fluid index. Routine antenatal and color Doppler (including kidneys) ultrasound was performed for all patients in this study. The postnatal follow‐up was done, and the pregnancies having poor outcomes in terms of NICU admissions were assessed.ResultsStatistically significant differences were noted when comparing RI and PI values of normohydramnios (0.91 ± 0.04 and 2.38 ± 0.21, respectively) with oligohydramnios (1.02 ± 0.07 and 2.99 ± 0.38, respectively) and polyhydramnios (0.90 ± 0.12 and 2.7 ± 0.84, respectively) independently (p value < 0.05). Our study demonstrated an increase in NICU admissions in the fetus having raised values of RI and PI.ConclusionFetal RA RI and PI can be used as an antenatal predictor for the pregnancy outcome associated with idiopathic oligohydramnios; however, fetal RA PI was found to be a better predictor for the pregnancy outcome than fetal RA RI value in our study.
Small molecules (CO2, iPrNCO, and iPrNCNiPr) activation by the metallomimetics (μ‐Hydrido) diborane anion: A DFT investigation on mechanism and chemoselectivity controlling
Authors: Sun ChenFei , Liu Qing , Meng Lingpeng , Li Xiaoyan 
Published: October 2023

AbstractMain‐group metallomimetics provide a new way to replace transition metal complexes to activate inert small molecules under mild conditions. In this work, the activation mechanisms of CO2, iPrNCO, and iPrNCNiPr by (μ‐Hydrido) diborane anion ([1H]−) have been investigated by density functional theory (DFT) calculations. Two different activation sites, BB versus BH bond of [1H]−, are investigated and compared. The results show that these inert molecules can be activated by [1H]− through cycloadditions under mild conditions. The reactions with iPrNCO and iPrNCNiPr are dynamic and thermodynamic controlling, the obtained products are related not only to the energy barrier but also to the stability of the products. Moreover, the competition for BB/BH bond site activation is directly related to the steric effect of small molecules. CO2, which is without steric hindrance, can only be activated by the BB bond, whereas iPrNCNiPr can only be activated by the BH bond due to the large steric effect. The medium iPrNCO can be activated not only by the BB bond but also by the BH bond. Our study provides theoretical explanations for the reaction activity and chemoselectivity controlling of the title reaction, and displays the potential applications for compounds containing boron‐boron bonds and inert small molecule activation.
Zinc oxide‐doped carbon aerogel derived from bagasse cellulose/sodium alginate/zinc nitrate composite for dye adsorption, storage energy and electrochemical sensing
Authors: Lam Cao Vu , Vy Dang Ngoc Chau , Duyen Nguyen Hoang Kim , Xuan Nguyen Thien Thanh , Trinh Trinh Tu , Linh Nguyen Hoang Gia , Ngan Nguyen Xuan , Tu Phan Minh , Son Nguyen Truong , Hieu Nguyen Huu 
Published: October 2023

AbstractBACKGROUNDFollowing the trend of green and sustainable development, multi‐application materials utilizing biomass waste have been developed, leading that trend is carbon aerogel (CA). In this study, zinc oxide‐doped CA was synthesized from bagasse cellulose (Zn‐BCA) through simple processes: Cross‐linking to form a sol–gel system, freeze‐drying, and pyrolysis. To synthesize suitable materials, precursor and crosslinking ratios, the content of Zn2+, and pyrolysis temperature in N2 were investigated. The characteristics of ZnO were investigated through modern methods: Scanning electron microscopy, Raman spectroscopy, X‐ray diffraction, Fourier‐transform infrared spectroscopy, and energy‐dispersive X‐ray spectroscopy. The dye adsorption capacity of Zn‐BCA was evaluated through the UV–Vis method. Furthermore, the electrochemical properties are shown through cyclic voltammetry, galvanostatic charge‐discharge, electrochemical impedance spectroscopy results, and glucose sensing results were obtained through linear sweep voltammetry.RESULTSZn‐BCA shows potential for multiple applications with crystal violet pigment adsorption capacity up to 39 mg/g, specific capacitance reaching 164 F/g, and glucose sensing capabilities.CONCLUSIONThus, Zn‐BCA shows wide applicability in adsorbents and electrode materials, in addition to using bagasse biomass as green precursor to synthesize materials. © 2023 Society of Chemical Industry (SCI).
Bio‐reductive synthesis of silver nanoparticles, its antibacterial efficiency, and possible toxicity in common carp fish (Cyprinus carpio)
Authors: Kakakhel Mian Adnan , Narwal Nishita , Khan Alam , Ayub Huma , Jiang Zewen , Xiaotao Shi 
Published: October 2023

AbstractThe biological synthesis of nanoparticles is an emerging field of study that seeks to synthesize nanoparticles using non‐chemical mechanisms such as microorganisms, plants, and animal blood serum. Among these, plants have gained particular attention due to their ease of handling, availability, and ability to synthesize a wide range of nanoparticles. Therefore, the current study aimed to fabricate the silver nanoparticles (AgNPs) using Chinese medicinal plants (CMP) for their possible toxicity in common carp fish (Cyprinus carpio). For this purpose, CMP was dried, ground, and used as a bio‐reductive agent. The fabricated AgNPs were characterized and a well dispersed AgNPs were obtained. Moreover, the C. carpio was exposed to the AgNPs for bioaccumulation and histological alterations. The obtained findings revealed that the AgNPs were mostly accumulated in the intestines followed by the gills, muscles, liver, and brain. The accumulated AgNPs caused histological alterations in gills and intestines at the highest concentration (0.08 mg/L). However, very less alterations were caused by the lowest concentration, especially in the intestine. In conclusion, further in‐depth research is needed to determine the risks associated with the usage of nanoparticles to reveal their harmful impacts on fish and the aquatic environment.Highlights
The biological fabrication of AgNPs is considered eco‐friendly.
Chinese medicinal plants play a significant role in AgNPs synthesis.
AgNPs have excellent antibacterial activity.
AgNPs are bioaccumulated in various organs of fish.
The inflammatory response‐related robust machine learning signature in endometrial cancer: Based on multi‐cohort studies
Authors: Zhou Chufan , Xiang Pan , Xu Xindi , Yue Chaomin , Gao Kefei 
Published: October 2023

AbstractUterine corpus endometrial carcinoma (UCEC) is a prevalent form of cancer in women, affecting the inner lining of the uterus. Inflammation plays a crucial role in the progression and prognosis of cancer, making it important to identify inflammatory response‐related subtypes in UCEC for targeted therapy and personalized medicine. This study discovered significant variation in immune response within UCEC tumors based on molecular subtypes of inflammatory response‐related genes. Subtype A showed a more favorable prognosis and better response to immunotherapies like anti‐CTLA4 and anti‐PDCD1 therapy. Functional analysis revealed subtype‐specific differences in immune response, with subtype A exhibiting higher expression of genes related to cytokine signaling pathways, NK cell‐mediated cytotoxicity pathways and inflammatory processes. Subtype A also showed increased sensitivity to three chemotherapeutic agents. A 12‐gene inflammatory response‐related signature was found to have prognostic value for 1, 2 and 3 year survival in UCEC patients. Additionally, a validated machine learning‐based signature demonstrated significant differences in clinical traits between low‐risk and high‐risk cohorts. Elevated risk scores were associated with higher pathological grading, older age, advanced stage and immune subtype C2. Low‐risk groups had higher infiltration of immune cell types such as CD8 + T cells and activated CD4 + cells. However, the abundance of cytotoxic immune cells decreased with increasing risk scores. Finally, PCR was applied to test the different expression in P2PX4. P2RX4 knockdown inhibited the proliferation and proliferation of the endometrial carcinoma Ishikawa cell line. In conclusion, this developed signature can serve as a clinical prediction index and reveal distinct immune expression patterns. Ultimately, this study has the potential to enhance targeted therapy and personalized medicine for UCEC patients.