bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Simultaneous Dense Zinc Deposition and Broken Side‐Reaction Loops in the Zn//V2O5 System
Authors: Wang Huirong , Zhou Anbin , Hu Zhengqiang , Hu Xin , Zhang Fengling , Song Zhihang , Huang Yongxin , Cui Yanhua , Cui Yixiu , Li Li , Wu Feng , Chen Renjie 
Published: January 2024

AbstractThe Zn//V2O5 system not only faces the incontrollable growth of zinc (Zn) dendrites, but also withstands the cross‐talk effect of by‐products produced from the cathode side to the Zn anode, inducing interelectrode talk and aggravating battery failure. To tackle these issues, we construct a rapid Zn2+‐conducting hydrogel electrolyte (R‐ZSO) to achieve Zn deposition modulation and side reaction inhibition in Zn//V2O5 full cells. The polymer matrix and BN exhibit a robust anchoring effect on SO42−, accelerating Zn2+ migration and enabling dense Zn deposition behavior. Therefore, the Zn//Zn symmetric cells based on the R‐ZSO electrolyte can operate stably for more than 1500 h, which is six times higher than that of cells employing the blank electrolyte. More importantly, the R‐ZSO hydrogel electrolyte effectively decouples the cross‐talk effects, thus breaking the infinite loop of side reactions. As a result, the Zn//V2O5 cells using this modified hydrogel electrolyte demonstrate stable operation over 1,000 cycles, with a capacity loss rate of only 0.028 % per cycle. Our study provides a promising gel chemistry, which offers a valuable guide for the construction of high‐performance and multifunctional aqueous Zn‐ion batteries.
Identification of Cu(111) as Superior Active Sites for Electrocatalytic NO Reduction to NH3 with High Single‐Pass Conversion Efficiency
Authors: Xiao Lei , Mou Shiyong , Dai Weidong , Yang Weiping , Cheng Qin , Liu Siyuan , Dong Fan 
Published: January 2024

AbstractOpting for NO as an N source in electrocatalytic NH3 synthesis presents an intriguing approach to tackle energy and environmental challenges. However, blindly pursuing high NH3 synthesis rates and Faradaic efficiency (FE) while ignoring the NO conversion ratio could result in environmental problems. Herein, Cu nanosheets with exposed (111) surface is fabricated and exhibit a NO‐to‐NH3 yield rate of 371.89 μmol cm−2 h−1 (flow cell) and the highest FE of 93.19±1.99 % (H‐type cell). The NO conversion ratio is increased to the current highest value of 63.74 % combined with the development of the flow cell. Additionally, Crystal Orbital Hamilton Population (COHP) clearly reveals that the “σ‐π* acceptance‐donation” is the essence of the interaction between the Cu and NO as also supported by operando attenuated total reflection infrared spectroscopy (ATR‐IRAS) in observing the key intermediate of NO−. This work not only achieves a milestone NO conversion ratio for electrocatalytic NO‐to‐NH3, but also proposes a new descriptor that utilizes orbital hybridization between molecules and metal centers to accurately identify the real active sites of catalysts.
In situ Light‐Writable Orientation Control in Liquid Crystal Elastomer Film Enabled by Chalcones
Authors: Xu Yiyi , Zhang Xinfang , Song Zhenpeng , Chen Xiao , Huang Yinliang , Wang Jinyu , Li Bingxiang , Huang Shuai , Li Quan 
Published: January 2024

AbstractLiquid crystal elastomers (LCEs) are stimulus‐responsive materials with intrinsic anisotropy. However, it is still challenging to in situ program the mesogen alignment to realize three‐dimensional (3D) deformations with high‐resolution patterned structures. This work presents a feasible strategy to program the anisotropy of LCEs by using chalcone mesogens that can undergo a photoinduced cycloaddition reaction under linear polarized light. It is shown that by controlling the polarization director and the irradiation region, patterned alignment distribution in a freestanding LCE film can be created, which leads to complex and reversible 3D shape‐morphing behaviors. The work demonstrates an in situ light‐writing method to achieve sophisticated topography changes in LCEs, which has potential applications in encryption, sensors, and beyond.
Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes
Authors: Abu‐Dief Ahmed M. , El‐Khatib Rafat M. , El‐Dabea Tarek , Feizi‐Dehnayebi Mehran , Barnawi Ibrahim Omar , Alsehli Amal H. , Al‐Ghamdi Khalaf , El‐Remaily Mahmoud Abd El Aleem Ali Ali 
Published: January 2024

New Cu (II), VO (II), Ag(I), and Pd (II)‐[BIP = 4,6‐dimethyl‐N‐(octahydro‐2H‐benzimidazol‐2‐ylidene)pyrimidin‐2‐amine] chelates have been synthesized by the reaction of BIP ligand resulting from the condensation of benzimidazole guanidine as well as acetylacetone with tested metal salts. The suggested structures of prepared compounds have been investigated spectroscopically through (FT‐IR, NMR, Mass spectra, and UV–Vis spectra), CHN analyses, conductivity, pH stability as well asmagnetic moment measurements. TGA studies have been also studied to govern the thermal behavior, stability, and decomposition of the metal chelates. Structural study of the tested chelates exposed their chemical transformation of ligand by chelation with the studied metals. The studies predicted a hexa‐coordinated geometry for the Cu and VO chelates, whereas tetra‐coordinated for the Ag and Pd chelates. DFT/B3LYP theoretical method was applied to obtain optimized geometry, molecular electrostatic potential (MEP) surface, and HOMO‐LUMO analysis for tested compounds. For estimation in the in vitro study, all the tested compounds have been screened for their biochemical features, including antioxidant, antimicrobial performances, and cytotoxicity. The antioxidant performance of prepared molecules has been studied by DPPH study and all the tested chelates displayed close antioxidant performance against the standard drugs. The cytotoxic analysis of tested compounds has been estimated against various cancer cell lines: (Hep‐G2, HCT‐116, and MCF‐7) using MTT analysis as well as calculated the cell viability for the corresponding human cell. The DNA binding capability for the tested compounds has been evaluated through absorption spectroscopic, viscosity estimation, as well as gel electrophoresis. The outcomes displayed a good binding tendency through the binding constant from 1.01 × 104to 1.99 × 104 M−1in the order BIPCu> BIPVO > BIPPd > BIPAg, respectively. Finally, docking simulation results indicated that the complexes were located in the intercalation site of DNA and confirmed experimental findings.
Study on the combination of the annular jet pump and static mixer to improve the fluid‐carrying capacity of gas wells
Authors: Liang Huizhen , Li Chengzhen , Ma Jian , Mu Lin 
Published: January 2024

AbstractAiming at the problem that the suction chamber of the gas‐driven jet pump has insufficient mixing of the power gas and the sucked fluid leading to efficiency reduction, this study proposes to effectively combine the static mixer with the annular jet pump and design a new type of annular jet pump and apply it to the gas wells to improve the fluid recovery capacity. Numerical simulations based on the gas–liquid two‐phase flow model are carried out for a conventional annular jet pump (CAJP) and a new annular jet pump (NAJP). The reliability of the simulation results is verified by gas–liquid two‐phase flow experiments, and the differences between the two in terms of velocity, pressure loss, and turbulent kinetic energy are analyzed. Meanwhile, the validity of NAJP is verified, and the effects of different structures such as static mixer torsion angle, suction chamber angle, and area ratio on the performance of NAJP are analyzed. The results show that NAJP enhances the degree of mixing between the sucked fluid and the power gas through the cyclonic effect created by the static mixer compared with CAJP. It results in a 10.6% year‐on‐year increase in the velocity of the sucked fluid, a 3% year‐on‐year increase in the pressure drop, and a 12.2% year‐on‐year increase in efficiency. NAJP can significantly improve the fluid‐carrying performance. With a mixer angle of 210°, a suction chamber angle of 21°, and an area ratio of 1.77, the NAJP achieves an efficiency of 39.7%, which is a year‐on‐year increase of 7.3% compared to the structure under the same conditions before optimization. This study lays a foundation for the determination of the optimal design scheme of the annular jet pump and at the same time can provide theoretical and technical support for researchers in related fields.
Structure‐guided design of potent JAK1‐selective inhibitors based on 4‐amino‐7H‐pyrrolo[2,3‐d]pyrimidine with anti‐inflammatory efficacy
Authors: Zhang Jiahao , Xing Shuming , Cui Jianming , Wei Xiujian , Cao Zhi , Shao Bin , Jiang Nan , Zhai Xin 
Published: January 2024

AbstractIn a continuous effort to develop Janus kinase 1 (JAK1)‐selective inhibitors, a novel series of 4‐amino‐7H‐pyrrolo[2,3‐d]pyrimidine derivatives bearing the piperidinyl fragment were designed and synthesized according to a combination strategy. Through enzymatic assessments, the superior compound 12a with an IC50 value of 12.6 nM against JAK1 was identified and a 10.7‐fold selectivity index over JAK2 was achieved. It was indicated that 12a displayed considerable effect in inhibiting the pro‐inflammatory NO generated from lipopolysaccharide (LPS)‐induced RAW264.7 macrophages, while on normal RAW264.7 cells, 12a exerted a weak cytotoxicity effect (IC50 = 143.3 μM). Furthermore, H&E stain assay demonstrated the conspicuous capacity of 12a to suppress CCl4‐induced hepatic fibrosis levels in a dose‐dependent manner in vivo. The binding model of 12a ideally reflects the excellent activity of JAK1 over the homologous kinase JAK2. Overall, 12a, a JAK1‐selective inhibitor, exhibited potential for liver fibrosis and inflammatory diseases.
A comprehensive stem cell laboratory module with blended learning for medical students at Tongji University
Authors: Xu Jie , Shao Zhihua , Jia Song , Sha Jihong , Li Jiao , Gao Furong , Shi Xiujuan , Wang Juan , Jin Caixia , Jiang Mei , Tian Haibin , Cao Jinfeng , Pu Hu , Xu Lei , Lu Lixia 
Published: January 2024

AbstractThe laboratory practice “Primary culture and directional differentiation of rat bone marrow mesenchymal stem cells (BMSCs)” is part of a required course for sophomore medical students at Tongji university, which has been conducted since 2012. Blended learning has been widely applied in medical courses. Based on a student‐centered teaching philosophy, we reconstructed a comprehensive stem cell laboratory module with blended learning in 2021, aiming to facilitate students in enhancing their understanding of the multi‐lineage differentiation potential of stem cells and improve their experimental skills, self‐directed learning ability, and innovative thinking. First, we constructed in‐depth online study resources, including videos demonstrating laboratory procedures, a PowerPoint slide deck, and published literature on student self‐learning before class. In class, students performed a primary culture of BMSCs, freely chose among adipogenic, osteogenic, or chondrogenic differentiation, and used cytochemical or immunofluorescence staining for identification. After class, the extracurricular part involved performing quantitative polymerase chain reaction to examine the expression of multi‐lineage differentiation marker genes, which was designed as an elective. After 2 years of practice, positive feedback was obtained from both students and faculty members who achieved, the learning goal as expected. The reconstructed stem cell laboratory module provides comprehensive practice opportunities for students. Students have a better understanding of BMSC at the molecular, cellular, and functional levels and have improved their experimental skills, which forms a basis for scientific research for medical students. Introducing blended learning into other medical laboratory practices thus seems valuable.
The value of an MRI‐based radiomics model in predicting the survival and prognosis of patients with extrahepatic cholangiocarcinoma
Authors: Wang Limin , Liu Jiong , Zeng Yanyan , Shu Jian 
Published: January 2024

AbstractObjectivesThe study aimed to establish radiomics models based on magnetic resonance imaging (MRI) multiparameter images to predict the survival and prognosis of patients with extrahepatic cholangiocarcinoma (ECC).MethodsSeventy‐eight patients with ECC confirmed by pathology were collected retrospectively. The radiomics model_a/b/c were constructed based on the 1/2/3‐year survival of patients with ECC. The best texture features were selected according to postoperative survival time and ECC patient status to calculate the radiomics score (Rad‐score). A cutoff value was selected, and patients were divided into high‐risk and low‐risk groups.ResultsModel_a, model_b, and model_c were used to predict 1‐, 2‐, and 3‐year postoperative survival rates, respectively. The area under the curve values in the training and test groups were 1.000 and 0.933 for model_a, 0.909 and 0.907 for model_b, 1.000 and 0.975 for model_c, respectively. The survival prediction model based on the Rad‐score showed that the postoperative mortality risk differed significantly between risk groups (p < 0.0001).ConclusionsThe MRI radiomics model could be used to predict the survival and prognosis of patients with ECC.
Bone mineral density fall during aromatase inhibitor treatment may predict lower breast cancer recurrence
Authors: Martin Hilary , Redfern Andrew 
Published: January 2024

AbstractPurposeAromatase inhibitors (AIs) are associated with reduction in bone mineral density (BMD). The use of bone strengthening agents zoledronic acid and denosumab are associated with improved breast cancer outcomes for post‐menopausal patients treated with AIs. This study investigates whether change in BMD with AI therapy is associated with breast cancer recurrence.MethodsA cohort of patients treated at a single institution diagnosed with hormone receptor‐positive breast cancer with baseline BMD and subsequent BMD test while receiving adjuvant aromatase inhibitor therapy were studied. Demographic, treatment and outcome data was obtained. Simple and multiple linear regression analysis was performed to investigate predictors of annual percent BMD change at the LS and hip. Univariate and multivariate Cox proportional hazards modelling were undertaken to investigate predictors of breast cancer recurrence.Results353 patients eligible patients were identified. In multivariate analysis of lumbar spine BMD change, the difference between those in quartile 1, which showed the greatest reduction in BMD, and quartile 3, with substantially less reduction, was significant (HR = 3.02, 95% CI 1.15–7.90 p = 0.025). Hip BMD reduction was also not significantly associated with breast cancer recurrence. The two quartiles with the least reduction in hip BMD showing a non‐significant reduced risk of recurrence relative to the quartile with the greatest (p = 0.10).ConclusionsThe findings suggest an association may exist between lumbar spine BMD change and breast cancer recurrence for patients treated with adjuvant AI. Further research is required to determine whether BMD change can be utilised as a biomarker.
A study of machine learning models for rapid intraoperative diagnosis of thyroid nodules for clinical practice in China
Authors: Ma Yan , Zhang Xiuming , Yi Zhongliang , Ding Liya , Cai Bojun , Jiang Zhinong , Liu Wangwang , Zou Hong , Wang Xiaomei , Fu Guoxiang 
Published: January 2024

AbstractBackgroundIn China, rapid intraoperative diagnosis of frozen sections of thyroid nodules is used to guide surgery. However, the lack of subspecialty pathologists and delayed diagnoses are challenges in clinical treatment. This study aimed to develop novel diagnostic approaches to increase diagnostic effectiveness.MethodsArtificial intelligence and machine learning techniques were used to automatically diagnose histopathological slides. AI‐based models were trained with annotations and selected as efficientnetV2‐b0 from multi‐set experiments.ResultsOn 191 test slides, the proposed method predicted benign and malignant categories with a sensitivity of 72.65%, specificity of 100.0%, and AUC of 86.32%. For the subtype diagnosis, the best AUC was 99.46% for medullary thyroid cancer with an average of 237.6 s per slide.ConclusionsWithin our testing dataset, the proposed method accurately diagnosed the thyroid nodules during surgery.
Cost‐effectiveness analysis of continuing bevacizumab plus chemotherapy versus chemotherapy alone after first progression of metastatic colorectal cancer
Authors: Li Yulian , Hu Min , Zhang Zhe , Chu Mingming , Xu Rufu , Liu Lulu , Dong Wenxing , Yang Mengmeng , Zhang Rong 
Published: January 2024

AbstractBackgroundContinuation of bevacizumab plus second‐line chemotherapy has significantly improved overall and progression‐free survival in patients with metastatic colorectal cancer (mCRC). However, the cost‐effectiveness of such high cost therapy is still uncertain in China; so this analysis was performed to evaluate the cost‐effectiveness of these treatment options from the Chinese health care system perspective.MethodsA cost‐effectiveness analysis was conducted using data from the ML18147 trial (ClinicalTrials.gov identifier NCT00700102) by modeling a partitioned survival model. Main evaluation indicators were quality‐adjusted life years (QALYs) and incremental cost‐effectiveness ratio (ICER) with a willingness to pay (WTP) threshold of $38,201 per QALY. One‐way and probabilistic sensitivity analyses were conducted to assess the robustness and stability of the model. Subgroup and scenario analyses were also performed to make our study more relevant.ResultsBevacizumab plus chemotherapy increased 0.12 QALYs and an incremental cost of $22,761.62 compared with chemotherapy, resulting in an ICER of $188,904.09 per QALY. The model was most sensitive to the utility of progression‐free survival and the cost of bevacizumab. Compared with chemotherapy, bevacizumab plus chemotherapy had a 0% cost‐effectiveness probability, and no cost‐effectiveness in subgroups at the WTP threshold of $38,201 per QALY. The scenario analysis found that bevacizumab biosimilar gained an ICER of $126,397.38 per QALY when assuming the cost of drugs was calculated at the most affordable price.ConclusionsAt the WTP threshold of $38,201 per QALY, continuation of bevacizumab plus chemotherapy is unlikely considered cost‐effective for patients after first progression of mCRC.
Metabolomic Approaches in Assessing the Insecticidal Activity of the Extracts from Argemone ochroleuca Sweet (Papaveraceae) Against Three Diverse Crop Pests of Economic Importance
Authors: Reyes‐Luna Alfonso , Yáñez‐Barrientos Eunice , Alba‐Mares Xochitl N. , Luis Olivares‐Romero José , Josabad Alonso‐Castro Ángel , Cruz Cruz David , Villegas Gómez Clarisa 
Published: January 2024

AbstractFor years, crop protection from pest attack, has been dominated by the use of synthetic insecticides. However, many of them can cause severe environmental problems and human health. In this context, the use of plant extracts constitutes an alternative to avoid this kind of contaminants. In this work, we investigated the chemical constituents and insecticidal activity of different extracts of leaves and stems of Argemone ochroleuca Sweet (Papaveraceae) against three economically important pests Sitophilos zeamais (Coleoptera:Curculionidae), Galleria mellonella (Lepidoptera:Pyralidae) and Xyleborus ferrugineus (Coleoptera:Scolytidae). A GC‐MS analysis mostly revealed the presence benzylisoquinoline alkaloids such as allocryptopine, protopine, among others. For the insecticidal activity, after nine hours of contact, the methanolic leaves extract showed a 100 % of mortality, followed by the dichloromethane stems extract with up to 93 % of mortality. The results suggest that the benzylisoquinoline alkaloids are involved in the insecticidal activity through the octopaminergic system of the tested insects.
Molecular insights on intracellular Wnt/β‐catenin signaling in alcoholic liver disease
Authors: Shree Harini Karthik , Ezhilarasan Devaraj , Mani Uthirappan 
Published: January 2024

AbstractAlcoholic liver disease (ALD) is one of the most common health problems worldwide, especially in developing countries caused by chronic consumption of alcohol on a daily basis. The ALD spectrum is initiated with the early stages of alcoholic fatty liver (steatosis), progressing to alcoholic steatohepatitis, followed by the later stages of fibrosis and in some cases, cirrhosis and hepatocellular carcinoma (HCC). The Wnt/β‐catenin signaling required for healthy liver development, function, and regeneration is found to be aberrated in ALD, attributed to its progression. This review is to elucidate the association of Wnt/β‐catenin signaling with various stages of ALD progression. Alcohol causes downregulation of Wnt/β‐catenin signaling components and thereby suppressing the pathway. Reports have been published that aberrated Wnt/β‐catenin signaling, especially the absence of β‐catenin, results in decreased alcohol metabolism, causing steatosis followed by steatohepatitis via lipid accumulation, lipid peroxidation, liver injury, increased oxidative stress and apoptosis of hepatocytes, contributing to the advancement of ALD. Contrastingly, the progression of later stages of ALD like fibrosis and HCC depends on the increased activation of Wnt/β‐catenin signaling and its components. Existing studies reveal the varied expression of Wnt/β‐catenin signaling in ALD. However, the dual role of the Wnt/β‐catenin pathway in earlier and later stages of ALD is not clear. Therefore, studies on the Wnt/β‐catenin pathway and its components in various manifestations of ALD might provide insight in targeting the Wnt/β‐catenin pathway in ALD treatment.
Particulate bone grafting with a resorbable collagen membrane and horizontal alveolar ridge augmentation with tenting screws in dental implant placement: A case report
Authors: Mirdad Amani 
Published: January 2024

Key Clinical MessageWe used a mixture of particulate bone grafts (xenografts/allografts) with tenting screws to prevent membrane collapse and covered the graft with a resorbable collagen membrane to guide bone regeneration. This strategy can exclude the need for additional procedures, such as non‐resorbable membranes and major block grafting surgeries. Although the initial outcomes are promising, continuous follow‐up is required to examine the stability of the newly regenerated bone and the long‐term success of the implant.AbstractThis case demonstrates the use of particulate bone grafts covered with a resorbable collagen membrane and supported by tenting screws to correct horizontal alveolar ridge defects. A man in his 40s presented with missing maxillary anterior central and lateral incisors and required a fixed dental prosthesis. One year before, #12, #11, #21, and #22 had been extracted. The area showed horizontal and slight vertical bone loss. We used a mixture of particulate bone grafts (xenografts and allografts) with tenting screws to prevent membrane collapse and covered the graft with a resorbable collagen membrane to guide bone regeneration. After 6 months, complete bone regeneration was achieved, and the dental implants were submerged in the bone. After another 6 months, the patient was administered with a fixed dental prosthesis. This method can be used to correct horizontal alveolar ridge defects and achieve esthetic restoration without the need for more extensive procedures.