bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescents' Perceived Opportunities for Creative Thinking, Creative Thinking Competency Belief and Career Interest in STEM: Joint Consideration of Situated Expectancy‐Value Beliefs and Gender
Authors: Saw Guan K. , Lin Shengjie , Kunisaki Lindsey T. , Culbertson Ryan , Megyesi‐Brem Kimberly 
Published: February 2025

ABSTRACTGender differences in creative thinking competency, career interest, and situated expectancy‐value beliefs in STEM, have been widely studied separately. This study brings these lines of research together by examining gender differences in the association between adolescents' perceived opportunities for creative thinking, creative thinking competency belief, and career interest in STEM, as well as the mediating role of STEM situated expectancy‐value beliefs. Results from structural equation models (SEMs) with 737 middle/high school students attending the Prefreshman Engineering Program (PREP) in the Southwestern United States showed that perceived opportunities for creative thinking in STEM education settings were positively associated with creative thinking competency belief and career interest in STEM, after controlling for pre‐measures and background characteristics. Multigroup SEM analyses indicated that there were no significant gender differences in the relationship between perceived opportunities for creative thinking in STEM and the two examined STEM outcomes in our student sample. A set of mediation analyses demonstrated that STEM expectancy belief, intrinsic value, and utility value serve as key mediators linking perceived opportunities for creative thinking in STEM to student STEM outcomes. However, only the indirect effect of perceived opportunities for creative thinking in STEM on creative thinking competency belief through STEM expectancy belief was significant for both girls and boys. The mediating effects of STEM intrinsic value on both outcomes and the mediating effect of STEM utility value on STEM career interest were only significant for boys and not girls. Taken together, the findings of this study advance our understanding of the benefits of opportunities for creative thinking in STEM for middle/high school students and the underlying mechanisms by which creative‐supporting contexts have influence on students STEM outcomes differently for girls and boys.
Presumed aortic thromboembolism in a 13‐year‐old dog, associated with an Amplatz canine duct occluder
Authors: Gregorio Rafaela Silva , Labrador Notario Jose Miguel 
Published: February 2025

AbstractA 13‐year‐old, female, neutered Border Collie visited the neurology department after suffering two separate episodes of hindlimb weakness and pain. The patient responded to rest and analgesia on both occasions, but continued to be reluctant to jump. Previous history reported closure of a patent ductus arteriosus, using an Amplatz canine duct occluder at the age of 1. An electrocardiogram‐gated computed tomography showed a lesion in the aortic arch, which was consistent with a thrombus, and was centred over the Amplatz canine duct occluder. A similar type of lesion was also found in the femoral artery. The recurrent and spontaneously resolving hindlimb weakness was thought to be related to thromboembolism of the external iliac arteries or their branches, associated with the thrombus in the aortic arch. Although rare, thrombus formation is a complication associated with the use of Amplatz type devices in humans, but it has never been reported in dogs with an Amplatz canine duct occluder.
Ultraviolet‐enhanced Fe0‐activated H2O2 process for the removal of refractory organic matter from landfill leachate: Performance and mechanism
Authors: Zhao Guonan , Feng Ke 
Published: February 2025

AbstractThe Fenton‐like process, utilizing zero‐valent iron (Fe0) and hydrogen peroxide (H2O2), is employed to degrade refractory organic matter in membrane bioreactor (MBR) effluent derived from landfill leachate. However, the rate‐limiting Fe2+/Fe3+ redox step diminishes treatment efficacy and generates substantial iron sludge. This study elucidates the mechanism by which ultraviolet (UV) irradiation augments the Fe0/H2O2 process for the removal of refractory organic matter in MBR effluent. The results show that the UV‐ enhanced H2O2 process effectively disrupts the aromatic structure of organic compounds, reducing molecular weight, degree of polymerization, and humification. Compared with the Fe0/H2O2 process, the removal efficiency of UV254, color number, and total organic carbon in the effluent treated by the UV/Fe0/H2O2 process increased by 24.16%, 14.62%, and 57.46%, respectively. Concurrently, the generation of iron sludge was reduced by 21.6%. This enhancement is primarily attributed to UV's ability to intensify the Fe2+/Fe3+ redox cycle and expedite the surface corrosion of Fe0, yielding more iron oxides. This accelerates the decomposition of H2O2, generating a higher quantity of •OH through both homogeneous and heterogeneous Fenton‐like reactions. The refractory organic matter is removed through the oxidation by •OH, as well as the adsorption and precipitation facilitated by iron‐based colloids.Practitioner Points
UV promotes Fe0/H2O2 process to degrade refractory organic matter in MBR effluent.
UV promotes Fe0 to dissolve more Fe2+ and the redox cycle of Fe2+ and Fe3+.
The dosage of H2O2 or Fe0 influences the treatment effect of the process.
Preparation of the titanium‐based composite coagulant PTFS and its coagulation performance on nanoparticles
Authors: Wang Zihan , Ma Jingqian , Wu Kun , Sun Wenquan , Sun Yongjun 
Published: February 2025

AbstractIn this study, a titanium‐based coagulant, (i.e., PTFS), with a three‐dimensional spatial mesh structure was prepared for the coagulation removal of polystyrene (PS) and titanium dioxide (TiO2) nanoparticles in water. The results of scanning electron microscopy, TGA‐DSC, Fourier infrared spectroscopy, X‐ray diffraction, and X‐ray photoelectron spectroscopy characterization showed that the PTFS was not a simple mixture of raw materials and a chemical reaction occurred, thereby generating new chemically connected bonds. The optimum removal of PS could reach 92.5% at the dosage of 0.6 mg/L, initial concentration of 70 mg/L, pH of 7, stirring intensity of 350 rpm, settling time of 60 min, and kaolin concentration of 70 mg/L. The best removal rate of TiO2 could reach 95.3% when the dosage was 0.8 mg/L, the initial concentration was 70 mg/L, the pH was 7, the stirring intensity was 350 rpm, the settling time was 60 min, and the kaolin concentration was 50 mg/L. The flocs produced by PTFS were large and dense. In the early stage of coagulation, the flocculation mechanism was dominated by electroneutralization, and in the middle and late stages of coagulation, adsorption, bridging, and netting were dominated. This study aims to provide a reference for the removal of nanopollutants by coagulation in the actual water treatment process.Practitioner Points
A titanium‐based coagulant PTFS with a three‐dimensional spatial mesh structure was prepared.
PTFS effectively removes nano‐PS and nano‐TiO2 from water.
The flocs produced by PTFS were large and dense flocs.
Removal of PS and TiO2 by PFTS has been a combination of multiple coagulation mechanisms.
A numerical and statistical analysis of the unsteady ternary hybrid nanofluid flow and heat transfer over a generalized stretching/shrinking wall
Authors: Wahid Nur Syahirah , Roşca Natalia C. , Roşca Alin V. , Pop Ioan 
Published: February 2025

AbstractThis study analyzes unsteady ternary hybrid nanofluid flow and heat transfer over a generalized stretching/shrinking wall using both analytical and numerical methods. By applying similarity transformations, the governing nonlinear partial differential equations are reduced to a system of ordinary differential equations, which are numerically solved using the MATLAB bvp4c function. We find that the system exhibits two solution branches—an upper and a lower—within certain parameter ranges. A detailed stability analysis is conducted to determine the stability of these solutions. Additionally, the study presents analytical solutions for specific cases, which are relevant to heat exchangers in low‐velocity environments. Next, MINITAB software is used to statistically model the interactions of the parameters and assess their impact on the heat transfer performance (measured through the local Nusselt number), identifying low, medium, or strong effects through regression analysis. Finally, a sensitivity analysis is performed on the regression function obtained in MINITAB, focusing on key input parameters. To the best of our knowledge, this study is novel, as no previous work has explored this problem, making both the analytical and numerical results original.
Jung-Stilling’s Afterlife Visions in Their Interconfessional and Intercultural Contexts
Authors: Folliero-Metz Grazia Dolores 
Published: February 2025

Abstract
The present study examines Johann Heinrich Jung-Stilling’s writings Scenen aus dem Geisterreich and Theorie der Geisterkunde, treating them as significant lay theological publications and situating them within a broader European context. It identifies affinities with Dante Alighieri’s Divine Comedy and Friedrich G. Klopstock’s Messias, as well as with William Blake’s illustrations of Dante’s Comedy. Through comparative analysis, this chapter demonstrates the intricate interconnections between Stilling’s educational endeavours in popular religious culture and the canonical giants of cultural literature, illustrating a dynamic interplay of influence and divergence that spans both interconfessional and intercultural contexts.
The link frame model (LFM), a tool for the seismic analysis of timber frame buildings considering system effects
Authors: López Nicol , Berwart Sebastián , Guindos Pablo 
Published: February 2025

Abstract
This article proposes a model that makes possible the seismic analysis of timber frame multistory buildings in general-purpose software. The model is entitled link frame model (LFM) and shows the following advantages in comparison to previous models: (1) it can model shearwalls only with frame elements and links with errors close to 0% with respect to analytical code models such as e.g. the special design provisions for wind and seismic (SDPWS); (2) for seismic analysis, both the static analysis method and the modal spectral analysis method can be used, in addition to the gravitational analysis; (3) the computation of the natural period shows deviations close to 0% in comparison with eigenvalues and eigenvectors; (4) it can be implemented in general purpose structural analysis software such as e.g. ETABS or SAP2000; and (5) building system effects, i.e. interaction of shearwalls with other assemblies, can optionally be captured if assigning the proper diaphragm out-of-plane flexural stiffness. Given the great impact of this last aspect in practical design, and the lack of its research, this paper does not only present the model and validation itself, but also analyzes the consequences of considering system effects in a representative case study building. The analysis demonstrates that the average shearwall tension (uplift) of regular buildings can decrease by 80% if considering system effects, which could make timber buildings much more cost competitive in seismic countries.
Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma
Authors: Nakamura Mayuna , Tanaka Yuka , Hakoda Keishi , Ohira Masahiro , Kobayashi Tsuyoshi , Kurachi Kenji , Tamura Kouichi , Ohdan Hideki 
Published: February 2025

Abstract
Mortality and recurrence rates of hepatocellular carcinoma (HCC) remain high despite the use of various treatment methods. Recently, cell-based immunotherapy using natural killer (NK) cells has attracted considerable attention in cancer immunotherapy. NK cells generated from induced pluripotent stem cells (iPSCs) are a new option for use as an NK cell resource. The eNK cells (HLCN061, developed by HEALIOS K.K.) are human iPSC-derived NK cells differentiated from clinical-grade iPSCs in which IL-15, CCR2B, CCL19, CD16a, and NKG2D have been introduced. In this study, we aimed to evaluate the potential of eNK cell therapy for HCC treatment. The analysis of eNK cells for cell surface and intracellular molecules revealed that antitumor-related surface molecules (TRAIL, CD226, and CD16) and intracellular cytotoxic factors (perforin, granzyme B, TNFα, and IFNγ) were highly expressed. In addition, eNK cells exhibited high cytotoxicity against HCC cell lines (HepG2, HuH7, and SNU-423), which are sensitive to NKG2D, TRAIL, and CD226. The TRAIL and perforin/granzyme B pathways are largely involved in this cytotoxic mechanism, as indicated by the reduction in cytotoxicity induced by TRAIL inhibitory antibodies and concanamycin A, which inhibits perforin/granzyme B-mediated cytotoxicity. Our data suggest that eNK cells, whose functions have been enhanced by genetic engineering, have the potential to improve HCC treatment.
A machine learning approach for predicting the best heuristic for a large scaled Capacitated Lotsizing Problem
Authors: Kärcher Jens , Meyr Herbert 
Published: February 2025

Abstract
For some NP-hard lotsizing problems, many different heuristics exist, but they have different solution qualities and computation times depending on the characteristics of the instance. The computation times of the individual heuristics increase significantly with the problem size, so that testing all available heuristics for large instances requires extensive time. Therefore, it is necessary to develop a method that allows a prediction of the best heuristic for the respective instance without testing all available heuristics. The Capacitated Lotsizing Problem (CLSP) is chosen as the problem to be solved, since it is a fundamental model in the field of lotsizing, well researched and several different heuristics exist for it. The CLSP addresses the problem of determining lotsizes on a production line given limited capacity, product-dependent setup costs, and deterministic, dynamic demand for multiple products. The objective is to minimize setup and inventory holding costs. Two different forecasting methods are presented. One of them is a two-layer neural network called CLSP-Net. It is trained on small CLSP instances, which can be solved very fast with the considered heuristics. Due to the use of a fixed number of wisely chosen features that are relative, relevant, and computationally efficient, and which leverage problem-specific knowledge, CLSP-Net is also capable of predicting the most suitable heuristic for large instances.
Lower extremity MRI: are their requests always appropriate in France?
Authors: Degremont Adeline , Lindecker-Cournil Valérie , Bisquay Catherine , Ertel-Pau Valérie , Gabach Pierre , Lecocq Teixeira Sophie , Pialat Jean-Baptiste , Jachiet Pierre-Alain , Boyer Louis , Faruch-Bilfeld Marie 
Published: February 2025

Abstract

Objectives
The primary aim is to assess current lower extremity MRI requests’ relevance with a secondary focus on the knee.

Materials and methods
Using data from the National Health Data System (SNDS), we conducted an observational study of adults (18+) who underwent lower extremity MRI between July 1 and December 31, 2021. This study included analyzing medical consultations and imaging procedures (particularly X-rays) in the 6 months before and after the index MRI, as well as medical procedures and hospitalizations related to knee procedures within 6 months post-MRI.

Results
During the study period, 779,721 adults underwent lower extremity MRI, marking a 76% increase compared to a previous study conducted in 2012. General practitioners requested MRI in 70.5% of cases, often as the primary imaging modality. Notably, 52.1% of patients had not undergone lower extremity X-rays in the 6 months preceding MRI, and 13% underwent at least two MRI examinations within a year. Focusing on the knee, most patients (80%) did not undergo any outpatient medical procedure or hospitalization involving the knee within the 6 months post MRI.

Conclusion
In France, lower extremity MRI, particularly knee MRI, is frequently used as a first-line imaging procedure, unlike what is recommended.

Key Points

Question

How often are requests for lower extremity MRI examinations appropriate?

Findings

Lower extremity MRI is often performed as a first-line imaging procedure, even though it is not recommended.

Clinical relevance

The study findings underscore the importance of disseminating guidelines regarding lower extremity MRI appropriateness to increase its availability for appropriate purposes, thereby improving patient care.
Polycythemia vera and essential thrombocythemia in children, still a challenge for pediatricians
Authors: Picard Agathe , Bayart Sophie , Deparis Marianna , De Maricourt Cécile Dumesnil , Haro Sophie , Jourdain Anne , Mallebranche Coralie , Rialland Fanny , Luque Paz Damien , Pastoret Cedric , Gandemer Virginie , Cousin Elie 
Published: February 2025

Abstract
Polycythemia vera (PV) and essential thrombocythemia (ET) are rare myeloproliferative neoplasms (MPN) in children, adolescents and young adults. No recommendations are available concerning these patients’ management. Transposing to children the knowledge established in adult patients is not acceptable. For a better understanding of difficulties encountered by pediatricians and adult hematologists, we conducted a national practice analysis concerning follow-up of patients under 18 diagnosed with ET or PV, in France. Then, we present data from a multicentric, descriptive, retrospective study, including 17 patients with ET or PV, diagnosed under 18, coming from 7 hematopediatric departments in France. Interviewed physicians reported a lack of expertise and theoretical training in the hematological field to diagnose and follow children with MPNs. Data from 17 patients (15 ET, 2 PV) confirmed a high proportion of asymptomatic patients at the time of diagnosis (41%). Proportion of “triple-negative” patients (59%) was higher than in adult cohorts. 60% of patients underwent a bone marrow biopsy and 31% of cases were discussed during a multi-disciplinary staff meeting. 76.5% patients were treated, with a high frequency of antithrombotic and cytoreductive drugs. No complications were observed during the 45 months of median follow-up. Conclusion: Physicians insisted on the need for training. Only the accumulation of descriptions of MPNs in children will lead to a better management of these diseases. Considering the small proportion of pediatric patients with complications after diagnosis, rapid therapeutic de-escalation seems essential to consider during the follow-up in a close collaboration with adult hematologists.

What is Known:
• Myeloproliferativ neoplams are rare and chronic deseases, most of the time affecting adults but also found in few pediatric patients. • There are no recommendations for the diagnosis, therapeutic management or follow-up of children with polycythemia vera or essential thrombocythemia.

What is New:
• Find out how adult haematologists and paediatricians feel about the management and follow-up of paediatric patients with myeloproliferative syndrome through a national practice analysis. • Description of the “real life” follow-up of children with polycythemia vera or essential thrombocythemia in France.
Surgical risk stratification and outcome analysis of Tenckhoff catheter implantations in paediatric patients: a single-centre experience
Authors: Aftzoglou Michail , Dadouli Katerina , Eich Gwendolyn , Reinshagen Konrad , Tomuschat Christian 
Published: February 2025

Abstract
This study aimed to assess the risk factors for complications post-Tenckhoff catheter implantation in paediatric patients. All records of children who underwent the procedure from 2002 to 2022 at the University Medical Centre of Hamburg were analyzed. The demographic and anthropometric characteristics were scrutinized, with particular attention given to complications such as catheter leakage, occlusions, and peritonitis. Univariate and multivariate analyses were employed to determine the hazard ratios for complications. In total, 299 implantations were performed in 116 females and 130 males; 67% were under 5 years old, and 85% had renal disease. Fifty-one percent needed an acute catheter insertion, 26% of the patient‘s required revision, and 24% of the patients experienced peritonitis. Neonates had a 22% mortality rate, and infants had a 37% reimplantation rate. Compared with the other subgroups, a glomerular filtration rate of 15–29 ml/kg/1.7 3m2 was associated with a 10.7-fold higher risk of peritonitis. Male patients had a threefold greater chance of reimplantation or inguinal hernia. Omentectomy revealed no increased risk of peritonitis, and only two catheter occlusions were observed. Patients with inguinal hernias or gastric tubes had higher odds of complications (HR = 3.60, p = 0.003 and OR = 2.47, p = 0.014). Neither the implantation side nor acute insertion was correlated with complications.

Conclusion: Infants, male patients with kidney disease, prolonged use of catheter, and those with a GFR of 15–29 ml/kg/1.73 m2 were at increased risk. The presence of peritonitis, inguinal hernia, and gastric tubes were adverse prognostic factors.

What is Known:• Omentectomy can serve as a protective factor and correlates with a lower incidence of catheter malfunction.• The insertion of gastric tubes is commonly associated with complications but has lower risk of complications if inserted prior to the initiation of peritoneal dialysis.

What is New:• Males have been found to have a 2.14 hazard ratio for revision in both acute and chronic peritoneal dialysis groups.• The incidence of revisions seems to be greater in the first 36 months, while the incidence of peritonitis rises by 7% for each additional year of age.
Relationships between tilt angles of rectus muscles and positions of rectus muscle pulleys in patients with sagging eye syndrome
Authors: Kono Reika , Hamasaki Ichiro , Kishimoto Fumiko , Shibata Kiyo , Morisawa Shin , Morizane Yuki 
Published: February 2025

Abstract

Purpose
To examine the relationship between the rectus muscle (RM) angle and RM pulley displacement in patients with sagging eye syndrome (SES) without myopia.

Study design
Retrospective cross-sectional case series.

Methods
High-resolution quasi-coronal magnetic resonance imaging (MRI) data from 20 orbits of ten Japanese patients with SES but without high myopia were analyzed. The patients had no abduction deficiency. The RM angles were measured between the major axes of the horizontal and vertical RMs relative to the vertical and horizontal planes, respectively. The positions of the RM pulleys relative to the center of the globe were analyzed as previously described.

Results
The mean age of the patients was 75.8 ± 4.5 years (standard deviation). The average axial length was 23.6 ± 0.6 mm. The lateral rectus (LR) muscle angle (22 ± 6°) had moderate negative correlations with the inferior displacement of the inferior rectus (IR), superior rectus (SR), and LR pulleys (r =– 0.63,– 0.45, and– 0.45, respectively); however, no change was observed in the medial rectus (MR) pulley (r =– 0.41). No correlations were found between the angles of the SR (4 ± 8°), IR (– 13 ± 8°), and MR (– 1 ± 6°) muscles and the positions of the RM pulleys.

Conclusion
Given the correlation between increased LR muscle angle and inferior displacement of adjacent RM pulleys in SES, the LR muscle angle may serve as a diagnostic clue, even when inferior displacement is not identifiable on MRI. Further confirmation in larger studies is warranted.