bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mecanismos de resistencia a la colistina, la nitrofurantoina y la fosfomicina en Enterobacterias
Authors: González-Carballo Gian Carlo , García-Marín Cristina 
Published: October 2023

Las enterobacterias son un grupo amplio y heterogéneo de bacilos Gram negativos que se aíslan de forma rutinaria en el laboratorio clínico y se asocian a una gran cantidad de cuadros clínicos. Aquellas resistentes a antibióticos de última línea, como a los carbapenémicos, representan un gran reto en los centros de salud. Ante la dificultad para tratar infecciones causadas por este tipo de bacterias, se ha retomado el uso de antimicrobianos clásicos como la colistina, la nitrofurantoína y la fosfomicina. El objetivo de este trabajo es detallar los principales mecanismos de resistencia para estos tres fármacos descritos en enterobacterias. Para ello, se efectuó una revisión bibliográfica de artículos científicos publicados entre los años 1999 y 2022, utilizando las bases de datos PubMed (NCBI), PLOS, Redalyc, Google Scholar y Science Direct. En este proceso, se usaron las palabras clave “Carbapenem-Resistant Enterobacteriaceae”, “colistin”, nitrofurantoin”, “fosfomycin”, “resistance” y “plasmids”. Se encontró que los mecanismos de resistencia son variados y abarcan fenómenos como modificación del sitio blanco, inactivación enzimática, impermeabilidad y eflujo. Además, los determinantes genéticos de resistencia se encuentran en cromosomas o en plásmidos. Conocer este tipo de información permite mejorar la vigilancia basada en el laboratorio, combatir el problema de resistencia a los antimicrobianos y optimizar el uso de estos antibióticos que forman parte del escaso arsenal para el tratamiento de ciertas infecciones causadas por microorganismos multidrogorresistentes.
O USO DE ZOLPIDEM, SEUS EFEITOS ADVERSOS E A QUALIDADE DE SONO: UMA ANÁLISE ENTRE OS ESTUDANTES DE MEDICINA DE UMA INSTITUIÇÃO DO OESTE DO PARANÁ
Authors: Brill Julia Alana , Alrai Omar Abdalalim , Oliveira Juliano Karvat de 
Published: October 2023

O uso de medicamentos para modular o sono é extremamente comum entre universitários, embora o apelo seja a melhora da condição, consigo estes fármacos trazem inúmeros efeitos indesejados. Objetivo foi avaliar o uso de Zolpidem, os efeitos adversos e a qualidade do sono entre estudantes de medicina de uma instituição particular do oeste do Paraná. Trata-se de um estudo transversal, exploratório, descritivo, com levantamento de dados por meio da aplicação de questionário pela plataforma Google Forms® para acadêmicos de medicina do 1º ao 6º ano, com 18 anos ou mais. A coleta de dados ocorreu no primeiro semestre de 2023 após a aprovação do Comitê de Ética sob CAAE nº 65005722.1.0000.5219. Responderam à pesquisa 64 participantes destes, 68,7% afirmaram possuir diagnóstico de algum transtorno psiquiátrico (ansiedade 47,7% e depressão 22,7%). A maior parte da amostra (67,2%) relatou fazer uso ou já ter utilizado algum medicamento para dormir, destes, (39%) responderam ter sido o Zolpidem. O tempo médio de utilização foi de 18 meses. A receita originada de um médico psiquiatra esteve presente em 52% dos casos. Sobre o uso do Zolpidem, 60% respondeu fazê-lo apenas em condições especiais, 28% todos os dias, 8% quatro vezes na semana e 4% duas vezes. Dentre os usuários de Zolpidem, 80% relatou ter pelo menos um efeito adverso, alucinação foi a mais frequente (28,5%), seguido por delirium (22,8%), amnésia (20%), pesadelos (20%) e sonambulismo (8,7%).
Inferring neutral winds in the ionospheric transition region from atmospheric-gravity-wave traveling-ionospheric-disturbance (AGW-TID) observations with the EISCAT VHF radar and the Nordic Meteor Radar Cluster
Authors: Günzkofer Florian , Pokhotelov Dimitry , Stober Gunter , Mann Ingrid , Vadas Sharon L. , Becker Erich , Tjulin Anders , Kozlovsky Alexander , Tsutsumi Masaki , Gulbrandsen Njål , Nozawa Satonori , Lester Mark , Belova Evgenia , Kero Johan , Mitchell Nicholas J. , Borries Claudia 
Published: October 2023

Abstract. Atmospheric gravity waves and traveling ionospheric disturbances can be observed in the neutral atmosphere and the ionosphere at a wide range of spatial and temporal scales. Especially at medium scales, these oscillations are often not resolved in general circulation models and are parameterized. We show that ionospheric disturbances forced by upward-propagating atmospheric gravity waves can be simultaneously observed with the EISCAT very high frequency incoherent scatter radar and the Nordic Meteor Radar Cluster. From combined multi-static measurements, both vertical and horizontal wave parameters can be determined by applying a specially developed Fourier filter analysis method. This method is demonstrated using the example of a strongly pronounced wave mode that occurred during the EISCAT experiment on 7 July 2020. Leveraging the developed technique, we show that the wave characteristics of traveling ionospheric disturbances are notably impacted by the fall transition of the mesosphere and lower thermosphere. We also demonstrate the application of using the determined wave parameters to infer the thermospheric neutral wind velocities. Applying the dissipative anelastic gravity wave dispersion relation, we obtain vertical wind profiles in the lower thermosphere.
Accounting for precipitation asymmetry in a multiplicative random cascade disaggregation model
Authors: Maloku Kaltrina , Hingray Benoit , Evin Guillaume 
Published: October 2023

Abstract. Analytical multiplicative random cascades (MRCs) are widely used for the temporal disaggregation of coarse-resolution precipitation time series. This class of models applies scaling models to represent the dependence of the cascade generator on the temporal scale and the precipitation intensity. Although determinant, the dependence on the external precipitation pattern is usually disregarded in the analytical scaling models. Our work presents a unified MRC modelling framework that allows the cascade generator to depend in a continuous way on the temporal scale, precipitation intensity and a so-called precipitation asymmetry index. Different MRC configurations are compared for 81 locations in Switzerland with contrasted climates. The added value of the dependence of the MRC on the temporal scale appears to be unclear, unlike what was suggested in previous works. Introducing the precipitation asymmetry dependence into the model leads to a drastic improvement in model performance for all statistics related to precipitation temporal persistence (wet–dry transition probabilities, lag-n autocorrelation coefficients, lengths of dry–wet spells). Accounting for precipitation asymmetry seems to solve this important limitation of previous MRCs. The model configuration that only accounts for the dependence on precipitation intensity and asymmetry is highly parsimonious, with only five parameters, and provides adequate performances for all locations, seasons and temporal resolutions. The spatial coherency of the parameter estimates indicates a real potential for regionalisation and for further application to any location in Switzerland.
ЧИСЛЕННОЕ ИССЛЕДОВАНИЕ ВОПРОСА НЕЕДИНСТВЕННОСТИ РЕШЕНИЙ ЗАДАЧИ ШОУОЛТЕРА – СИДОРОВА ДЛЯ МАТЕМАТИЧЕСКОЙ МОДЕЛИ ДЕФОРМАЦИИ ДВУТАВРОВОЙ БАЛКИ
Authors: Манакова Наталья , Николаева Надежда , Гаврилова Ольга , Перевозчикова Ксения 
Published: October 2023

Работа посвящена численному исследованию вопроса единственности решения задачи Шоуолтера – Сидорова – Дирихле для уравнения Хоффа на отрезке. Уравнение Хоффа моделирует динамику деформации двутавровой балки, находящейся под постоянной нагрузкой. Для исследования вопроса (не)единственности решений задачи Шоуолтера – Сидорова будет использован метод фазового пространства, который был разработан Г.А. Свиридюком при исследовании разрешимости уравнений соболевского типа. Ранее было показано, что фазовое пространство исследуемой модели содержит особенности типа 2-сборки Уитни, что влечет за собой возможную неединственность решений. Представлены условия единственности или множественности решений задачи Шоуолтера – Сидорова – Дирихле в зависимости от параметров системы, построен алгоритм численного решения задачи на основе метода Галеркина и представлены вычислительные эксперименты.
О РЕШЕНИЯХ СИСТЕМ ЛИНЕЙНЫХ ИНТЕГРАЛЬНЫХ УРАВНЕНИЙ ФРЕДГОЛЬМА ТРЕТЬЕГО РОДА С ВЫРОЖДЕННЫМИ МАТРИЧНЫМИ ЯДРАМИ НА ПОЛУОСИ
Authors: Асанов Авыт , Асанов Рухидин , Асанова Каныкей 
Published: October 2023

Исследована система линейных интегральных уравнений Фредгольма третьего рода с вырожденными матричными ядрами но полуоси. Рассматриваемая система линейных интегральных уравнений третьего рода относиться к классу некорректных задач.На основе сравнительно нового подхода показано, что решения для одного класса систем линейных интегральных уравнений Фредгольма третьего рода с вырожденными матричными ядрами но полуоси эквивалентно решению систем линейных алгебраических уравнений. Далее,изучены вопросы существования и единственности решения для этой системы линейных интегральных уравнений третьего рода.
THE EFFICACY AND SAFETY OF SILODOSIN FOR THE TREATMENT OF BENIGN HYPERPLASIA PROSTATE: A SYSTEMATIC REVIEW
Authors: Sapta Putra Steven 
Published: October 2023

Background: BPH is a prevalent and costly condition affecting the quality of life for older men. adrenoceptor antagonists provide effective relief for bothersome symptoms but do not prevent the need for surgery or acute urinary obstruction. Silodosin, newer adrenoceptor antagonist, offers comparable symptom relief to tamulosin
Aim: This systematic review evaluates the efficacy and safety of silodosin for the treatment of benign prostatic hyperplasia (BPH) and its suitability for daily clinical practice..
Methods: This systematic review examined the use of silodosin in men with benign prostatic hyperplasia (BPH). Multiple databases were searched for relevant literature. (PubMed and Cochrane Library)
Results: This systematic review included four randomized trials involving 2504 patients with benign prostatic hyperplasia. The analysis showed that silodosin demonstrated significant improvements in International Prostate Symptom Score, specifically in storage and voiding symptoms, compared to placebo.
Conclusion: Silodosin shows efficacy and safety for treating benign prostatic hyperplasia (BPH), but the higher incidence of retrograde ejaculation warrants further high-quality, long-term studies, including direct comparisons with tamsulosin.
Jóvenes Indígenas, Afrodescendientes y de Comunidades Locales de Latinoamerica Unidos por la Defensa de los Territorios Ancestrales
Authors:   Rights and Resources Initiative
Published: October 2023

Los días 6 y 7 de septiembre de 2023, un grupo de 18 jóvenes líderes Indígenas, Afrodescendientes y de comunidades locales de organizaciones de la Coalición de RRI se reunieron por primera vez en Bogotá, Colombia Los jóvenes líderes, procedentes de 10 países de América Latina, comparten un objetivo en común: defender las tierras ancestrales y los derechos territoriales de sus pueblos y comunidades, para la gestión sostenible de estos territorios y la protección de sus ecosistemas. Estos líderes también comparten un deseo: fortalecer los vínculos entre ellos y con otras redes juveniles de la región para afianzar sus habilidades de liderazgo y conocimiento en torno a los procesos de derechos territoriales, conservación liderada por las comunidades y adaptación al cambio climático Tras dos días de diálogo franco, los participantes crearon un Manifiesto que expresa sus prioridades mutuas con respecto a los procesos de conservación basados en los derechos y de gestión sostenible de la tierra de los que han formado parte en sus comunidades. En definitiva, este Manifiesto representa el deseo y compromiso de los representantes juveniles de continuar desarrollando sus habilidades de liderazgo y conocimientos para ser agentes activos de cambio en la defensa de los territorios ancestrales de sus pueblos y del planeta en su conjunto. El Manifiesto también servirá de guía a la coalición mundial de RRI, que se ha comprometido a incorporar el liderazgo y la participación de los jóvenes en sus actividades regionales y mundiales en el futuro.
Does Fibular Displacement Predict Tibial Malrotation in Simulated Tibia-Fibula Fractures
Authors: Robles Abrianna S. , Blough Christian L. , Kurapaty Steven , Lee Anderson , Ewing Brett A. , Marecek Geoffrey S. 
Published: October 2023

Introduction:
Tibial malrotation can occur with medullary nailing of diaphyseal tibial fractures. Fibular alignment has been proposed as a surrogate for axial plane reduction intraoperatively. The purpose of this study was to determine whether fibular alignment is a reliable marker of accurate tibial rotation.

Methods:
Deidentified CT scans of 50 patients with normal tibial anatomy were selected. Using ImageJ software, we simulated osteotomies at three sites (proximal third, mid-diaphysis, and distal third). We overlaid adjacent CT slices and rotated them around the central axis of the tibia in 5° increments of external rotation (ER) and internal rotation (IR). At each increment, measurements of fibular overlap (%) were obtained from anteroposterior (AP) and lateral views. To simulate fixation of the fibula, we repeated rotation around the axis of the fibula with and without a simulated medullary implant in the tibia.

Results:
A total of 50 patients were included. The mean age was 62 years, average BMI was 25.8, and 28 of 50 patients (56%) were male. Earliest loss of fibular contact occurred at 24° ER and 22° IR at the proximal site. Contact was lost at 26° ER and 28° IR on the AP view and 42° ER and 29° IR on the lateral view. The mean fibular contact at each 5° increment was similar for ER and IR. Fibular contact was reduced to 50% at 10 to 15° of rotation in ER and IR at all sites. Tibial canal contact was lost at 24° in both ER and IR around the fibula. With a virtual medullary implant, the mean maximal rotation was 6°.

Discussion:
Surgeons should be aware that 20° or more of malrotation is likely present when fibular contact is lost during medullary nailing of the tibia. Greater than 50% loss of contact should raise suspicion for malrotation. A fixed fibula and medullary tibial implant theoretically preclude significant tibial malrotation.
Analisa Rugi Daya Berbasis ETAP pada Jaringan Distribusi 20kV Penyulang Ahuru
Authors: Pratiwi Rizky Wulandari , Haurissa Marceau A F 
Published: October 2023

Proses penyaluran energi listrik melalui jaringan distribusi ke beban akan mengalami rugi-rugi daya terutama pada jaringan distribusi radial. Penyulang ahuru adalah termasuk penyulang dengan sistem radial yang sangat panjang. Panjang saluran peyulang Ahuru dari pangkal sumber GI Sirimau hingga ke ujung beban di Wayomar Seri adalah 33,91 kms, oleh sebab itu perlu dilakukan analisa berapa besar rugi daya teknis pada jaringan distribusi tegangan menengah 20 kV pada penyulang ahuru. Semakin panjang saluran distribusi semakin besar drop tegangan dan rugi daya teknis pada saluran distribusi tersebut. Kehilangan energi listrik secara teknis perlu diketahui dan diantisipasi agar berada dalam batas yang normal dan wajar sesuai SPLN. Analisa rugi daya dilakukan menggunakan simulasi ETAP dengan pilihan metode newton raphson, dimana single line diagram (SLD) penyulang ahuru didisain sesuai data real kedalam aplikasi ETAP. Hasil penelitian diperoleh setelah running ETAP 12.6 didapati nilai rugi-rugi daya penyulang ahuru pada kondisi normal sebesar 295,1kW atau 7,48%, pada waktu beban puncak (WBP) sebesar 271,9kW atau 6,76%, dan luar waktu beban puncak (LWBP) sebesar 209,1kW atau 6,25%. Berdasarkan hasil analisa tersebut diperoleh besar rugi daya teknis telah melebihi presentase dari SPLN. Setelah melakukan perbaikan sistem pada ETAP dan melakukan simulasi load flow, diperoleh data rugi daya teknis hasil perbaikan pada waktu beban puncak (WBP) sebesar 166kW atau sebesar 4,13% yang mana masih memenuhi batas presentase rugi daya sesuai SPLN No. 72 tahun 1987 yaitu sebesar 5%.
The History of Brittany from the 13th to the 21st Century
Authors: Coativy Yves 
Published: October 2023

Attempting to present eight centuries of Breton history in one article is of course a daunting task and my aim here is simply to provide an outline highlighting the major trends and events that will enable the reader seeking a historical introduction to better understand Breton history and culture. Covering such a long span of time necessarily implies selecting only the most salient historical events and aspects of Brittany’s cultural development.
Until the Revolution of 1789, there were nine Catholic dioceses in Brittany and Breton history inscribed itself within the administrative framework of the Church. In three of these Breton dioceses (Léon, Trégor, Cornouaille) Breton was by far the dominant language; in the dioceses of Saint-Brieuc and Vannes people spoke Breton and French or Gallo (a romance language with Latin roots), while in those of Nantes and Dol, Gallo or French were spoken, with Breton used in an enclave situated in the area around Guérande. The diocese of Dol was particular in that its possessions were disseminated throughout Brittany and as far as the Norman border. This reflects the donations it had received from the Breton aristocracy.
The use of the Breton language varied through the centuries, with the Breton-speaking areas receding westwards as time went by. The impact that this had on Breton history should not be underestimated: Brittany shares this linguistic plurality with other regions or states like Belgium, Switzerland or Canada and the Celtic countries. The linguistic status of Breton is considerably different though since it is not officially recognised by the French government. This should be kept in mind when considering the nature of Breton cultural and political identities until the present day.
FORMAÇÃO DE PROFESSORES DA REDE PÚBLICA MUNICIPAL DE EDUCAÇÃO DE SÃO LUÍS/MA PARA A PROGRESSÃO NA CARREIRA FUNCIONAL: ENTRE A EXIGÊNCIA E A PRÁTICA
Authors: Scrima Jucineide Silva , Da Silva Bruna Victória Silva , Reis Odilea Silva Aguiar , Da Silva Otávio Bruno Silva , Dos Remédios Pamela Carvalho Ferreira 
Published: October 2023

Este trabalho resulta do estudo realizado pelos autores na Secretaria Municipal de Educação- SEMED/SÃO LUÍS/MA sobre a formação inicial e continuada de professores da Rede Pública Municipal de Educação. Os resultados das ações dessa secretaria são considerados para estudo, apenas no horizonte temporal de 2021 a 2023. A pesquisa segue abordagem qualitativa, a partir da análise de entrevistas com professores, professores suporte pedagógico, gestores escolares, superintendentes, técnicos de núcleo e coordenadores de setor por meio de questionário on-line do Google Forms. O estudo teve como objetivo destacar a formação inicial e continuada oferecida aos profissionais da educação, nos anos 2021, 2022 e 2023 no sentido que estes possam progredir na carreira funcional cumprindo o disposto no Plano de Cargos, Carreiras e Vencimento dos Profissionais do Magistério do Sistema de Ensino Público da Prefeitura de São Luís (PCCV) - LEI Nº 4931, DE 07 DE ABRIL DE 2008. A pesquisa conclui que a Secretaria de educação do município de São Luís, ofertou formação continuada para os profissionais da rede de educação, mas apresenta ressalvas na questão.
Deel of geheel?
Authors: Broers L.B. , Buiten L.G. 
Published: October 2023

Deel of geheel? Een visie op de toepassing van de streefcijferregeling door vennootschappen met een monistisch bestuursmodel
Sinds 1 januari 2022 kent Nederland een streefcijferregeling om een evenwichtigere man-vrouwverhouding te bereiken in de top van het bedrijfsleven. De regeling is toegeschreven op vennootschappen met een dualistisch bestuursmodel. Dit artikel gaat in op de toepassing van deze regeling door vennootschappen met een monistisch bestuursmodel.
Een emissiereductiebevel aan bestuurders van vervuilende vennootschappen
Authors: Kroeze R. 
Published: October 2023

Een emissiereductiebevel aan bestuurders van vervuilende vennootschappen. Zijn bestuurders na de Nederlandse Staat en Shell de volgende in de rij?
Deze bijdrage onderzoekt de mogelijkheid om een emissiereductiebevel op te leggen aan bestuurders van vervuilende vennootschappen. Hierbij zet de auteur het juridisch kader van de gebodsvordering jegens bestuurders uiteen en gaat zij in op de vraag of een reductieverplichting van bestuurders kan worden gebaseerd op de ongeschreven zorgvuldigheidsnorm.
Természetvédelmi célú botanikai, takarmányozástani és talajtani vizsgálatok a Tapolcai és Káli-medence szürkemarha és bivaly legelőin
Authors: Penksza Károly , Tasi Julianna , Szentes Szilárd , Centeri Csaba 
Published: October 2023

In the present work we introduce the coenological and pedological results of examination on the Balaton Upland (Badacsonytördemic, Csobánc, Káptalantóti and Kővágóőrs). Grass management plays an important role in nature conservation, rural development thus in the viability of rural population. Soil and water suffer from extreme degradation and pollution, partly because of agricultural activities, growing settlements and mining activity. We evaluated the changes in species composition and coverage, the possibly occurring regeneration or degradation and the effects of botanical composition changes on forage values, especially in case of economically valuable species. Investigations show strengths and weaknesses of having animals on grasslands. Sample sites were in Balaton Upland National Park, Hungary. Results proved that among the plants there are either weeds and/or poisonous and/or prickly species, too. We examined how important grasses and pulses appeared or disappeared, how did the number of overgrazing tolerant species changed and how did the species composition of the grazed and non-grazed land differed. Based on the results the characteristics of the examined pastures show the effects of overgrazing. With the decrease of the number of the animals, nature conservation and economical values could be increased. The examined areas had totally different soil characteristics, pH, soil thickness and nutrient content varied greatly. In the Gyulakeszi area even a small catena was found on a single pasture. The high soil organic matter and nutrient content ensure the good grass yield thus the areas are suitable for grazing and for grass cutting, too.
Állati magterjesztés, kiemelten a vaddisznó (Sus scrofa) szerepe a növényzeti mintázatok kialakulásában – áttekintés
Authors: Mráz Benedek , Katona Krisztián 
Published: October 2023

A pollináció mellett a növényi szaporítóképletek terjesztése a növényi génáramlás egyik legfontosabb biztosítója. Az állatok általi magterjesztés (zoochoria) a hatékonysága és a terjesztési távolság nagysága miatt fontos szerepet tölt be a növényi génáramlásban. A terjesztett növények lehetnek számunkra, illetve az adott életközösség számára hasznosak, de nem kívánatosak is (például őshonos vs. idegenhonos fajok). Jelen irodalmi áttekintés célja képet adni az állati magterjesztés, kiemelten egy nagyhatású, és igen ellentmondásos megítélésű vadfajunk, a vaddisznó (Sus scrofa) magterjesztésének a növényzeti mintázatok alakításával betöltött ökológiai szerepéről, pozitív és negatív hatásairól. A téma természetvédelmi szempontból, illetve mindazon gazdálkodási ágazatok (erdő- és vadgazdálkodás, gyepgazdálkodás, szántóföldi növénytermesztés) szemszögéből is érdekes lehet, amelyek számára valamilyen módon jelentősek azok a lágyszárú és fásszárú növények, amelyeket a vaddisznók terjeszthetnek.