bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Design and Implementation of BPPT-lock Armored Groin for Sediment Control Structure in Front of Sea Water Intake
Authors: Firmansyah Raka , Jauzi Muhammad Zuhdan , Istiyanto Dinar Catur , Subarkah Aris , Sujoko Sungsang Urip , Wibowo Mardi , Yuniardi Rizaldi Caesar 
Published: January 2024

High rate accumulation of sediment materials in front of the sea water intake (SWI) of a petrochemical factory cooling water system has caused high maintenance dredging costs. A study was conducted to identify the pattern and rate of sedimentation and to find an engineering solution that enables controlling sedimentation rate reduction. Based on numerical simulation, it is identified that the existing total rate of sedimentation around the channel in front of the SWI is 50cm/year. Further numerical simulation series revealed an optimum mitigation scenario by the construction of a pair of groin along both sides of the channel in front of the SWI as a sediment control structure. Under this scenario, the average bed level change becomes 0.10 cm/year and the maximum value of the bed level change is around 24.96 cm/year. A BPPT-lock armored rubble mound-type structure was designed for this sediment control groin by considering its feasibility, ease of construction, and local availability of structure materials. BPPT-lock is selected due to its high hydraulic stability (KD) of 17 for the trunk application and 13 for the head application. It is found that about twenty-five percent more armor unit numbers were required at the final stage of construction compared to the designed one. The actual method of armor unit placement and arrangement during construction is considered the main cause of this difference. In this case, the calculation was designed for random placement, but the actual construction was in uniform placement. To provide economical insight, a calculation was made to compare the construction budget requirement between this constructed groin armored with BPPT-lock and if the same structure armored with tetrapod. The calculation result shows that BPPT-lock armor units required 64% less budget compared to the tetrapod.
Le récit de Théramène au Pays de Québec. Une lecture du Vendeur de Sébastien Pilote
Authors: Bélanger David 
Published: January 2024

L’espace est intimement lié à la tragédie. De Phèdre à Maria Chapdelaine jusqu’au Vendeur de Sébastien Pilote, cet article s’attache à démontrer la parenté des ressorts tragiques dans ces oeuvres. Plus particulièrement, l’annonce — le récit de Théramène, le récit d’Eutrope, le récit des policiers — constitue le centre de cette étude. Le quiproquo, la fatalité monstrueuse, les divinités sont autant de variables redistribuées dans ces récits que l’analyse met à profit. À terme, il s’agit d’éclairer le film de Sébastien Pilote, en postulant, centrale, sa constituante tragique.
Répétitions et rêveries au centre du terroir. Trois variations sur l’imaginaire d’une région (Lefebvre, Édoin, Messier)
Authors: Carrier-Lafleur Thomas 
Published: January 2024

Le parti pris de cet article consiste à parcourir « l’imaginaire de l’espace » des récits québécois de la terre à partir de la focale privilégiée d’un seul et même lieu : celui de la paroisse de Saint-Armand, dans la région de Brome-Missisquoi. Il s’agira ainsi de prendre conscience des moyens par lesquels un espace unique arrive à se répéter, mais aussi, comment, par le biais de différents auteurs, il arrive à se différencier, c’est-à-dire à se recréer. Ce jeu entre répétitions du même et différences hétérogènes sera aussi l’occasion d’une enquête intermédiatique, alors que seront à la fois étudiés des récits romanesques, ceux de William S. Messier, ainsi que des récits filmiques, ceux de Guy Édoin et de Jean Pierre Lefebvre. La constante entre ces différentes fictions de l’espace est, précisément, la terre de Saint-Armand, dont nous découvrirons les diverses strates.
Normand McLaren : pensée-cinéma et cinéplastique
Authors: Chateau Dominique 
Published: January 2024

Dans le débat sur la pensée-cinéma, il n’est fait référence explicitement ou implicitement qu’à une certaine sorte de cinéma, narratif ou documentaire. Norman McLaren, par son oeuvre singulière comme par son domaine d’exercice, le cinéma d’animation, nous demande de réfléchir différemment sur ce sujet : comment la pensée-cinéma investit-elle ce genre de film où le diégétique régresse, tandis que le filmique même redevient l’enjeu majeur ? Comment cette exploration de la définition du médium travaille-t-elle la pensée et comment s’accommode-t-elle d’un privilège accordé à la plasticité filmique ? En plus du fort sentiment d’accomplissement que donne l’ensemble de son oeuvre, McLaren nous offre l’occasion de renouveler la théorie du cinéma en la pensant autrement.
L’esthétique rock queer, de C.R.A.Z.Y. à Xavier Dolan
Authors: Laverdière Gabriel 
Published: January 2024

L’analyse proposée des films C.R.A.Z.Y. (Jean-Marc Vallée, 2005), J’ai tué ma mère (Xavier Dolan, 2009), Les amours imaginaires (Dolan, 2010) et Laurence Anyways (Dolan, 2012) convoque trois perspectives : le rock, le camp et le queer. Dans ces films québécois, la musique rock semble orienter la narration et l’esthétique. Elle fait également le pont entre l’anticonformisme auquel renvoie le paradigme rock et l’identité marginale des personnages. L’esthétique de l’image se plie parfois à la bande sonore, qui encourage certains effets visuels. Cela dit, les films de Vallée et de Dolan se servent différemment de l’esthétique rock et du camp, ce qui s’accorde aux représentations distinctes qu’ils produisent eu égard à l’orientation ou à la diversité sexuelles et au genre. L’excès des films de Dolan, leur hyper-référentialité, leur jeu constant entre recherche d’émotions esthétiques et d’émois narratifs, leur fréquente suspension de la réalité contribuent à une écriture du différé dans laquelle les personnages queer jouissent d’une amplitude considérable, alors que dans C.R.A.Z.Y. la performance hyperbolique s’articule plutôt à une analytique de l’homophobie (sociétale et intériorisée) que le film s’efforce de dresser, sans pouvoir échapper à un certain malaise.
La réflexion médiatique dans Kid Sentiment de Jacques Godbout
Authors: Carrier-Lafleur Thomas , Lavoie Guillaume 
Published: January 2024

Réalisé en 1967 et sorti en 1968, Kid Sentiment propose une réflexion dont le sujet est au moins double. D’un côté, il s’agit d’enquêter sur la « jeunesse d’aujourd’hui », grâce à la participation de deux membres du groupe rock Les Sinners, François Guy et Louis Parizeau, accompagnés de leurs deux amies de coeur, Andrée Cousineau et Michèle Mercure, quatre jeunes gens qui pour l’occasion incarnent des adolescents très « à gogo » en pleine découverte de la carte de Tendre. Par un maillage très serré de modes de communications, dont le présent article proposera l’analyse structurale, Godbout explore les différentes situations et thématiques constitutives de l’imaginaire de cette jeunesse « gogo » ou « yéyé ». D’un autre côté, ce treizième film sert de laboratoire réflexif pour le réalisateur, dans la mesure où à la question symbolique « qu’est-ce que la jeunesse en 1967-68? » s’ajoute une réflexion formelle sur le statut du cinéma direct, dont Kid Sentiment représente une manifestation tardive, et en cela maniériste.
A peptide encoded by the circular form of the SHPRH gene induces apoptosis in neuroblastoma cells
Authors: Gao Jingjing , Pan Hong , Li Jie , Jiang Jun , Wang Wenxian 
Published: January 2024

Background
Circular RNAs (circRNAs) and their derived peptides represent largely unchartered areas in cellular biology, with many potential roles yet to be discovered. This study aimed to elucidate the role and molecular interactions of circSHPRH and its peptide derivative SHPRH-146aa in the pathogenesis of neuroblastoma (NB).

Methods
NB samples in the GSE102285 dataset were analyzed to measure circSHPRH expression, followed by in vitro experiments for validation. The role of SHPRH-146aa in NB cell proliferation, migration, and invasion was then examined, and luciferase activity assay was performed after SHPRH-146aa and RUNX1 transfection. Finally, the regulation of NB cell apoptosis by SHPRH-146aa combined with NFKBIA was tested.

Results
The GSE102285 dataset indicated overexpression of circSHPRH in NB samples, further supported by in vitro findings. Overexpression of circ-SHPRH and SHPRH-146aa inhibited proliferation, migration, and invasion of NB cells. A significant increase in apoptosis was observed, with upregulation of Caspase-3 and downregulation of Bcl-2. Furthermore, the peptide derivative SHPRH-146aa, derived from circSHPRH, suppressed NB cell malignancy traits, suggesting its role as a therapeutic target. A direct interaction between SHPRH-146aa and the transcription factor RUNX1 was identified, subsequently leading to increased NFKBIA expression. Notably, NFKBIA knockdown inhibited the pro-apoptotic effect of SHPRH-146aa on NB cells.

Conclusion
The study demonstrates that circ-SHPRH and SHPRH-146aa play significant roles in inhibiting the malignant progression of NB. They induce apoptosis primarily by modulating key apoptotic proteins Caspase-3 and Bcl-2, a process that appears to be regulated by NFKBIA. The SHPRH-146aa-RUNX1 interaction further elucidates a novel pathway in the regulation of apoptosis in NB. These findings indicate that circ-SHPRH and its derived peptide SHPRH-146aa could be potential therapeutic targets for NB treatment.
Adverse Events Following Immunization of COVID-19 Vaccines in People Vaccinated from June 2021 to March 2022 in Ouagadougou
Authors: Diallo Ismaël , Sawadogo Abdoulaye , Ouédraogo Gafourou Arsène , Ouédraogo Smaïla , Diendéré Eric Arnaud , Zoungrana Jacques , Bognounou Réné , Savadogo Mamoudou , Sondo Apoline Kongnimissom 
Published: January 2024

Aims: To study adverse events following immunization of Covid-19 vaccines in people vaccinated from June 14, 2021 to March 13, 2022 at the vaccination center of University Hospital Yalgado Ouedraogo.
Study Design: Our study was a descriptive and analytical cross-sectional study.
Place and duration of study: Department of Medicine, from June 14, 2021 to March 13, 2022 at CHU-YO.
Methodology: To identify the factors associated with the occurrence of adverse events following immunization, we used univariate binary logistic regression and a threshold of p < 0.2 was used for inclusion in the multivariate analysis. The significance threshold was then 0.05. We have obtained authorization to use the data from the ethics committee.
Results: A total of 646 people were included. The mean age was 49.84 years [18 - 78 years]. The sex ratio (M/F) was 1.73. Health workers accounted for 32.2% of those vaccinated. Hypertension, allergy and diabetes were the most frequently reported medical conditions in 15.2%, 10.4% and 6.7% of those vaccinated respectively. Four hundred and forty-eight 448 (69.3%) presented at least one adverse event following immunization, of which 446 (99.6%) were minor and 2 (0.4%) major. Pain at the injection site, headache and fever accounted for 87.4%, 82.6% and 67.8% of cases respectively. The two major adverse events following immunization were anaphylactic shock and hemiparesis. In the majority of cases, adverse events following immunization occurred within 48 h of COVID-19 vaccination. Healthcare workers and history of allergy were statistically associated with the occurrence of adverse events following immunization.
Conclusion: We need to study the adverse events following immunization associated with COVID-19 vaccines, in order to increase the population's adherence to the vaccine and better combat this Coronavirus pandemic.
Direct Numerical Simulation of Composite Structures
Authors: Kim Seung Jo , Lee Chang Sung , Yeo Hea Jin , Kim Jeong Ho , Cho Jin Yeon 
Published: July 2003

Fiber-reinforced composites are not chemical compounds but physical mixtures of fiber and matrix, and the constituents are bonded together. Therefore, it is natural and essential to adopt a full microscopic model and directly analyze the model with no assumptions for local deformation or local loading conditions, in order to understand and predict not only the averaged or homogenized behaviors but also the detailed microscopic behaviors of composite structures. However, in spite of the necessity, full microscopic models of composite structures have rarely been dealt with, mainly because of their difficulties arising in the actual computation of the finite element model with immense degree of freedoms. In this work, to overcome the difficulties and analyze full microscopic models of composite structures, an efficient parallel multifrontal solver, which can utilize distributed computing resources unlimitedly, is developed and applied to the Direct Numerical Simulation (DNS) of composite structures. Using the developed code, feasibility studies are carried out to observe whether or not the proposed solver is adequate for the DNS of composite structures, such as in parallel performance and others. As an example of DNS, virtual experiments are carried out, where material constants are directly obtained through DNS. Comparisons with previous experimental and theoretical results show the promising possibility that the present virtual experiments by the DNS of composite structures can be an alternative way to obtain material constants without expensive real experiments. Additionally, a microscopic model with defects is also analyzed and compared with a perfect model to validate the potential of the DNS in dealing with irregularity of microscopic models of composite structures coming from imperfection. The examples show the future direction of analysis and design of composite structures as well as the usefulness of the proposed DNS methodology.
Validation of the Quadratic Composite Failure Criteria with Out-of-Plane Shear Terms
Authors: Huybrechts Steven , Maji Arup , Lao Jennifer , Wegner Peter , Meink Troy 
Published: July 2003

The Tsai–Wu Quadratic Failure Criterion is a modified tensor polynomial criterion, that is widely used and the most readily accepted failure criterion for orthotropic materials. While it is an excellent criterion for the majority of composite structures, there is limited experimental validation of this criterion when predicting the failure envelope for “combined shear” failures or, better stated, failures that involve both 2-D (in-plane) and 3-D (out-of-plane) shear stresses in an orthotropic material or laminate. Since several common types of material failure involve complex stress states, the ability to incorporate the effect of 3-D shear stress into failure prediction is attractive. The 3-D Tsai–Wu quadratic failure criterion that incorporates multiple shear stresses is presented in this text and tests were conducted on several laminate specimens in an effort to validate this criterion. Failure load predictions were made to validate the modified 3-D criterion and compare the results with the 2-D Tsai–Wu criterion for specialized cases where multiple shear stresses were present at failure. This testing clearly shows strong agreement between the 3-D criterion’s predictions and experiments for these cases, implying that the standard 2-D Tsai–Wu quadratic failure criterion can be safely extended, through the addition of terms, to 3-D cases.
Cure Kinetic Model, Heat of Reaction, and Glass Transition Temperature of AS4/3501-6 Graphite–Epoxy Prepregs
Authors: Kim Jonghyun , Moon Tess J. , Howell John R. 
Published: July 2003

A new isothermally-based, cure kinetic model for the carbon graphite–epoxy AS4/3501-6 prepreg is presented using an industrially supplied prepreg rather than the neat epoxy resin. A two-stage model is used: first, rate-controlled (autocatalytic); then diffusion-controlled. A Differential Scanning Calorimeter (DSC) is employed to investigate the prepreg’s cure kinetics using both isothermal and dynamic DSC scans, although only isothermal DSC scan data is used to fit the model’s parameters. A Thermogravimetric Analyzer (TGA) is used to determine the mass fraction of the epoxy resin in the prepreg. The coefficients are provided for a prepreg having 37.4% resin mass fraction; they must be re-evaluated for prepregs having significantly different resin mass fractions. The ultimate heat of reaction of the resin incorporated within the prepreg is measured as 433.7 J/g (based upon a linear baseline) or 422.7 J/g (based upon a specific-heat-corrected baseline) using dynamic DSC scans at 20°C/min. This value is 8–17% less than the reported 472–508 J/g for the neat 3501-6 epoxy also measured using dynamic DSC scans at 20°C/min. Important to manufacturing applications, dynamic DSC scans reveal that the prepreg’s ultimate heat of reaction is sensitive to scan rate. Finally, the prepreg’s carbon fiber and/or sizing appears to suppress the curing reaction and decrease the ultimate heat of reaction over that for the neat epoxy resin. The glass transition temperature Tg (°C) of partially-cured AS4/3501-6 prepregs is measured using DSC and is expressed as a function of degree of cure: Tg = 22.9 exp(2.16α) – markedly similar to 3501-6 neat resin Tg data measured earlier using a dynamic mechanical analyzer. The small specimen DSC thermal scans provide an effective means to measure the Tg of completely- or partially-cured prepregs. The Tg of the 100%-cured prepreg was experimentally determined to be 199°C, slightly higher than the 193°C reported for the 100%-cured neat epoxy resin. The AS4 fibers play little or no role in the degree-of-cure dependence of the AS4/3501-6 prepreg’s Tg. Recommended for general purpose structural applications, the AS4/3501-6 prepreg is composed of continuous, PAN-based, AS4C carbon (graphite) fibers and an amine-cured epoxy resin system. The epoxy resin, 3501-6, is a tetraglycidyl diamino diphenyl methane (TGDDM) with diaminodiphenylsulfone (DDS) catalyzed with boron trifluoride monoethylamine. 3501-6 was developed to operate in atemperature environment of up to 350°F (177°C).
Population and Individual Bioequivalence: Lessons from Real Data and Simulation Studies
Authors: Zariffa Nevine M.‐D. , Patterson Scott D. 
Published: July 2003

The Food and Drug Administration (FDA) has proposed replacing the 1992 average bioequivalence (ABE) with population and individual bioequivalence (PBE & IBE), as outlined in the preliminary draft guidance of December 1997, which was subsequently replaced by the draft guidances of August 1999 and resolved in the final guidance of October 2000. This has led to considerable public debate among regulatory, academic, and industry experts at numerous conferences (e.g., FDA/AAPS March 1998, FDA/AAPS August‐September 1999, FDA Pharmaceutical Sciences Advisory Committee September 1999) and in the literature. The final guidance calls for ABE to remain as the primary criterion by which new formulations may be judged ready for access to the marketplace. In addition, the FDA recommends the use of replicate study designs for the specific drug classes of controlled release formulations and highly variable drugs. The final guidance also alludes to the possibility of a sponsor requesting alternative criteria such as PBE and IBE following consultation with the FDA. This procedure amounts to a data collection period during which data suitable to evaluate the operating characteristics of PBE and IBE would be generated, analyzed, and discussed among interested parties. A comprehensive review of currently available databases is useful in determining the ultimate value of this data collection period. This report provides an update to the previous publication by the authors. In all, 28 data sets from 20 replicate crossover bioequivalence studies have been analyzed (n = 12–96) using the statistical methodology in the most recent FDA draft guidance. The results are presented below.Review of the database reveals many interesting features, most notably the lack of consistent results within a given data set across all three criteria. The sensitivity of subject‐by‐formulation interaction to sample size and inherent variability of the compounds is further explored through simulation studies. It is concluded that additional simulation assessments must be considered when evaluating the value of a data collection period for PBE and IBE assessment. It will be shown that definitive conclusions regarding some of the operating characteristics of PBE and IBE can be achieved through a combination of data‐driven hypotheses followed by simulation studies to further evaluate the hypotheses. Some recommendations for further data collection will be made.
Contributions of Five Human Cytochrome P450 Isoforms to the N‐demethylation of Clozapine In Vitro at Low and High Concentrations
Authors: Olesen Ole V. , Linnet Kristian 
Published: July 2003

The authors assessed the in vitro contribution of cytochrome P450 (CYP) isoforms 1A2, 3A4, 2C9, 2C19, and 2D6 to the N‐demethylation of clozapine mediated by human liver microsomal preparations (HLM). In contrast to previous studies, the authors focused on a relatively low hepatic concentration level, 5 pM, to assess the conditions at a therapeutically relevant hepatic concentration level of clozapine. The optimal concentrations of specific inhibitors were ini‐tially established using cDNA‐expressed CYP isoforms. The mean contributions of CYPs 1A2, 2C19, 3A4, 2C9, and 2D6 amounted to 30%, 24%, 22%, 12%, and 6%, respectively, with regard to the total HLM‐mediated N‐demethylation.Thus, the present in vitro study on clozapine N‐demethylation suggests that CYP1A2 is the most important form at low concentrations, which is in agreement with clinical findings. CYP2C19 is also of considerable importance, while the roles of CYP2C9 and 2D6 are more modest. CYP3A4 attained a dominating role with an average contribution of 37% at a high clozapine concentration (50 μM). The rate of other metabolic routes mediated by CYP2D6 only corresponded to about one fifth of the CYP2D6catalyzed N‐demethylation rate.
Diverging Academic Paths in Rural Caribbean Village Children
Authors: Durbrow Eric H. , Schaefer Barbara A. , Jimerson Shane 
Published: July 2003

In many Caribbean countries, secondary school positions are rationed to children who pass an examination they take at age 12. In St Vincent, children from villages are more likely to fail this examination, the Common Entrance Examination, than are urban children. Despite being a major determinant in children's futures, little within community research has been conducted on factors influencing children's ability to pass this examination. We analysed longitudinal data from village children to identify accurate and early predictors of CEE passes. We included 66 children (35 boys, 31 girls). Academic scores and achievement test scores assessed academic performance. The Raven Coloured Progressive Matrices assessed abstract reasoning. A modified version ofthe Revised Behaviour Problem Checklist completed by teachers assessed behaviour problems. A modified version of the HOME Inventory and other measures assessed home environment. Discriminant analyses indicated that children's achievement, aca demic and behaviour problems and cognitive abilities as early as age 8 can predict later examination success or failure. Of these variables, achievement and academic performance were the most significant contributors. Results suggest that children's academic paths are estab lished by at least age 8 (Grade 3) and that children diverge academically and cognitively over the primary school years. Interventions designed to reduce the rural/urban gap in secondary school admissions may be more effective if started by age 8.