bluuebunny/crossref_metadata_2025_split huggingface dataset:
GÉNERO Y CULTURA POPULAR EN LA INTERVENCIÓN DE PLAZAS COMERCIALES PATRIMONIALES
Authors: Rodas García María Paula , Toledo Dumas Johanna Cecilia , Cabrera Jara Natasha 
Published: December 2023

Las áreas históricas en América Latina han experimentado procesos de patrimonialización relativamente recientes, donde los centros históricos, correspondientes al tejido de fundación española, han retomado importancia. En consecuencia, se han ejecutado un sinnúmero de proyectos sobre sus espacios públicos con la finalidad de regenerarlos. En el caso de las plazas comerciales, que históricamente han ocupado determinados entornos del área patrimonializada, estas intervenciones se han caracterizado por la búsqueda de un orden y estética que se contrapone a su condición marcadamente popular. Con el objetivo de identificar la problemática derivada de estos procesos de regeneración, los valores patrimoniales que mantienen y las características que invisibilizan o desplazan, se aplica un diseño metodológico basado en técnicas de observación y levantamiento de encuestas y entrevistas en dos plazas comerciales del Centro Histórico de Cuenca, en Ecuador, tras ser intervenidas luego de su declaratoria como Patrimonio Cultural de la Humanidad, en 1999. Se obtienen dos hallazgos fundamentales: por una parte, el importante uso de estos contextos por mujeres, niños y niñas, quienes son omitidos dentro de los proyectos de intervención; y el desplazamiento de determinadas características. Finalmente, se propone una revisión a la planificación de este tipo de intervenciones para tornarlamás horizontal; para ello, se toma en consideración tres escalas de actuación.
Palabras clave: Centro Histórico, mercado popular, regeneración urbana, perspectiva de género.
AbstractHistoric areas in Latin America have undergone relatively recent processes of heritagization, where historic centers corresponding to the urban grid of Spanish foundations have regained importance. As a result, countless projects have been implemented in their public spaces with the aim of regenerating them. In the case of commercial squares, which have historically occupied certain spaces of the heritage area, these interventions have been characterized by the search for order and aesthetics that contrast with their markedly popular condition. To identify the problems derived from these regeneration processes, the heritage values they maintain,and the characteristics they omit or displace, a methodological design based on observation techniques, surveys, and interviews was applied in two commercial plazas in the Historic Center of Cuenca in Ecuador, after they were intervened following their declaration as Cultural Heritage of Humanity in 1999. Two fundamental findings were obtained: on the one hand, the critical use of these contexts by women and children, who are omitted from the intervention projects, and the displacement of certain characteristics. Finally, a revision of the planning of this type of intervention is proposed in order to make it more horizontal, to this end, three scales of action are considered.
Keywords: Historic Center, popular market, urban regeneration, gender perspective.
ARQUITECTURA Y MODERNIDAD EN EL CAMPUS DE LA PONTIFICIA UNIVERSIDAD CATÓLICA DEL ECUADOR. 1957 - 1999
Authors: Del Pino Martínez Inés 
Published: December 2023

El artículo expone la morfología de los edificios del campus de la Pontificia Universidad Católica del Ecuador (PUCE). Las circunstancias iniciales de la construcción tienen relación con el cambio que experimentó Quito entre 1930 y 1960 en el orden urbano, arquitectónico y tecnológico, que permitieron entender la ciudad de manera diferente. En un contexto de menor escala, la arquitectura de la universidad también cambió, no solo por el traslado de la sede hacia la zona de expansión, sino los planes de estudio y la adopción de una arquitectura como representación de un momento histórico diferente. Este artículo tiene por objeto situar los momentos que marcaron hitos en su crecimiento. En este recorrido, destacan los nombres de importantes arquitectos de la década del cincuenta y sesenta como Sixto Durán Ballén, Virgilio Flores, Eduardo Gortaire, y más tarde, Fernando Calle. El artículo concluye que el campus fue construido por etapas, en un recorrido que va desde la arquitectura funcionalista y moderna hasta el reciclaje, la rehabilitación, nuevos materiales y técnicas, que marcan el inicio de una nueva etapa.
Palabras clave: Arquitectura moderna, campus universitarios, Quito, Pontificia Universidad Católica del Ecuador, educación.
AbstractThe article discusses the morphology of buildings on the Pontificia Universidad Católica (PUCE) campus. The initial circumstances of the campus construction are related to Quito's changes between 1930 and 1960 in the urban, architectural, and technological order, which allowed the city to be understood differently. In a smaller-scale context, the university's architecture also changed, not only because of the transfer of the headquarters to the expansion area but also because of the curricula and the adoption of an architecture that represented a different historical moment. This article aims to situate the moments that marked milestonesin its growth. In this journey, essential architects of the fifties and sixties, such as Sixto Durán Ballén, Virgilio Flores, Eduardo Gortaire, and later, Fernando Calle. The article concludes that the campus was built in various stages, from functionalist and modern architecture to recycling, rehabilitation, new materials, and techniques, which mark the beginning of a new phase.
Keywords: Modern architecture, university campus, Quito, Pontificia Universidad Católica del Ecuador, education.
Baseline investigation on enzyme induced calcium phosphate precipitation for solidification of sand
Authors: Gowthaman Sivakumar , Yamamoto Moeka , Chen Meiqi , Nakashima Kazunori , Kawasaki Satoru 
Published: December 2023

Introduction: Bio-cementation processes [namely, microbial induced carbonate precipitation (MICP) and enzyme induced carbonate precipitation (EICP)] have recently become promising techniques for solidifying loose sands. However, these methods release gaseous ammonia to the atmosphere, which is not desirable for real-scale applications. This study aims to propose an enzyme induced calcium phosphate precipitation (EICPP) method as a sustainable direction for the solidification of sand.Methods: Precipitation of calcium phosphate compound (CPC) was driven through pH-dependent mechanism regulated by enzymatic hydrolysis of urea. The baseline study was designed to consist of a series of precipitation tests and sand column tests, evaluating the influence of various recipes of cementation media (CM) on treatment efficiency. The evaluation program consisted of Unconfined compression tests, precipitation content measurement, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction.Results: The observations showed that the content of urea had an important role in proposed EICPP treatment, which determined the extent of the pH increase. This increase had a great influence on 1) utilization of soluble calcium, 2) precipitation content of calcium phosphate, and 3) the morphology of the precipitates. Results of sand column test suggested that injecting CM that consisted of acid-dissolved bone meal, urea and urease enzyme could result in the deposition of insoluble CPC that enabled the solidification of sand particles.Discussion: The precipitation quantity was found to increase with the increase in urea content; however, the treatment media with high urea content resulted amorphous-like crystals. The plate-like crystals were evidenced in CM with [Ca]/[urea] molar ratio between 1.5–2.0. X-ray Diffraction (XRD) analysis revealed that irrespective of the urea contents, the formed crystals were identified as brushite. Since the final pH of proposed EICPP method could be controllable within acidic-neutral conditions, the emission of ammonia gas would be eliminated.
Comparison of esketamine versus dexmedetomidine for attenuation of cardiovascular stress response to double-lumen tracheal tube intubation: a randomized controlled trial
Authors: Liu Chunyu , Zhang Tianhua , Cao Longhui , Lin Wenqian 
Published: December 2023

IntroductionThe insertion of a double-lumen tracheal tube may cause a transient but more intense sympathetic response. We examined the effects of esketamine vs. dexmedetomidine as an adjuvant to anesthesia induction to blunt double lumen tracheal (DLT) intubation induced cardiovascular stress response.MethodsIn a randomized, double-blind trial, 78 adult patients scheduled for elective thoracotomy under general anesthesia requiring DLT intubation were enrolled. The patients were randomly divided into three groups: each group received one of the following drugs prior to induction of anesthesia: dexmedetomidine 0.8 µg/kg (Group A), esketamine 0.5 mg/kg (Group B), or normal saline (group C). The primary outcome was the incidence of a DLT intubation-related cardiovascular stress response, defined as an increase in mean arterial pressure or heart rate of &gt;30% above the baseline values. The secondary outcomes were changes in hemodynamic and cardiac function.ResultsThe incidence of the response to cardiovascular stress was 23.1%, 30.8%, and 65.4% in groups A, B, and C, respectively. There was a significant decrease in intubation response in groups A and B in comparison with group C (P &lt; 0.01); however, there was no significant difference between group A and group B (P &gt; 0.05). Following the drug infusion and the induction of anesthesia, there was a significant decrease in HR and cardiac output in group A compared with group B. In contrast, no significant differences were observed in the left ventricular ejection fraction or in stroke volume between the three groups during induction of anesthesia.DiscussionEsketamine 0.5 mg/kg and dexmedetomidine 0.8 µg/kg attenuate cardiovascular stress responses related to DLT intubation. As adjuvants to etomidate induction, they do not impair cardiac function (ChiCTR1900028030).
Interrater variability of ML-based CT-FFR during TAVR-planning: influence of image quality and coronary artery calcifications
Authors: Gohmann Robin F. , Schug Adrian , Pawelka Konrad , Seitz Patrick , Majunke Nicolas , El Hadi Hamza , Heiser Linda , Renatus Katharina , Desch Steffen , Leontyev Sergey , Noack Thilo , Kiefer Philipp , Krieghoff Christian , Lücke Christian , Ebel Sebastian , Borger Michael A. , Thiele Holger , Panknin Christoph , Abdel-Wahab Mohamed , Horn Matthias , Gutberlet Matthias 
Published: December 2023

ObjectiveTo compare machine learning (ML)-based CT-derived fractional flow reserve (CT-FFR) in patients before transcatheter aortic valve replacement (TAVR) by observers with differing training and to assess influencing factors.BackgroundCoronary computed tomography angiography (cCTA) can effectively exclude CAD, e.g. prior to TAVR, but remains limited by its specificity. CT-FFR may mitigate this limitation also in patients prior to TAVR. While a high reliability of CT-FFR is presumed, little is known about the reproducibility of ML-based CT-FFR.MethodsConsecutive patients with obstructive CAD on cCTA were evaluated with ML-based CT-FFR by two observers. Categorization into hemodynamically significant CAD was compared against invasive coronary angiography. The influence of image quality and coronary artery calcium score (CAC) was examined.ResultsCT-FFR was successfully performed on 214/272 examinations by both observers. The median difference of CT-FFR between both observers was −0.05(−0.12-0.02) (p &lt; 0.001). Differences showed an inverse correlation to the absolute CT-FFR values. Categorization into CAD was different in 37/214 examinations, resulting in net recategorization of Δ13 (13/214) examinations and a difference in accuracy of Δ6.1%. On patient level, correlation of absolute and categorized values was substantial (0.567 and 0.570, p &lt; 0.001). Categorization into CAD showed no correlation to image quality or CAC (p &gt; 0.13).ConclusionDifferences between CT-FFR values increased in values below the cut-off, having little clinical impact. Categorization into CAD differed in several patients, but ultimately only had a moderate influence on diagnostic accuracy. This was independent of image quality or CAC.
Exploring public participation process and its differing degrees in influencing risk perception within the petrochemical industry: a scoping review
Authors: Gheitasi Mahdi , Serrano Giné David , Pérez-Albert Yolanda 
Published: December 2023

To evaluate perceived risk, it is necessary to understand both the type of risk and the residents’ perceptions. With the rise of information on technology and digital platforms, new avenues have emerged for examining citizens’ risk perception in participatory settings. However, the lack of theoretical and methodological approaches in this area calls for further research. The objective of this article is to fill the existing research gap by conducting a scoping review of published literature that examines risk perception related to the petrochemical industry, specifically focusing on digital platforms and the utilization of participatory processes in assessing risk perception within this industry context. The review analyzes the types of questions and responses encountered during participatory processes. The authors selected and studied 10 papers in-depth after applying specific selection criteria. They identified two types of risks—natural and technological—associated with the petrochemical industry, and two types of questions: general questions such as demographics, education, and employment, and specific questions such as risk perception, trust in government and company information, type of risk, or proximity to polluted areas. The paper identifies two question types in participatory processes: general and specific. It emphasizes that the most frequent participation level is consultation, involving seeking public feedback for decision-making. Risk perception is a common topic in participatory processes, highlighting the importance of understanding and addressing public concerns about activities risks. Understanding risk and questions raised during participation is crucial to studying risk perception. This knowledge can improve policies, identify risk mitigation solutions, and identify relevant questions to aid in logical answers.Systematic Review Registration:http://www.prisma-statement.org/?AspxAutoDetectCookieSupport=1
A climate-spatial matrix growth model for major tree species in Lesser Khingan Mountains and responses of forest dynamics change to different representative concentration path scenarios
Authors: Sheng Qi , Liu Zhaogang , Dong LingBo 
Published: December 2023

IntroductionClimate change affects forest distribution, species composition, structure, and yield due to the sensitivity of forests to temperature, precipitation, and CO2. Therefore, for forest management decisions regarding climate change, it is crucial to explore the response of forest growth, mortality, and recruitment to future climate. We aimed to establish tree species’ responses by introducing variables such as climate, stand spatial structure parameters, and diversity indices.MethodsWe produced fixed parameter transition matrix model (FM), climate-sensitive matrix growth model (CM) and climate-spatial matrix growth model (SCM) using data from 786 plots collected during the 7th (2010), and 8th (2015), Chinese National Forest Inventories in Heilongjiang Province, and long-term predictive performance of CM, SCM, and FM were compared using same data. The models were compared using tenfold cross-validation and long-term predictive performance analysis. To predict the response of major tree species in the Lesser Khingan Mountains to three future climate change scenarios (RCP2.6, RCP4.5, RCP8.5).Results and discussionThe cross-validation results show small significant differences among the three models for short-term prediction (5 years), with the FM performing slightly better than the CM and the SCM. In contrast, for long-term projections (85 years), SCM outperformed FM and CM under three different RCPs, and SCM and CM under three representative concentration paths (RCPs), i.e., RCP2.6, RCP4.5, and RCP8.5, suggesting that rather different dynamics are more reliable, since climatic factors are taken into account which may significantly affect forest dynamics, while changes in stand spatial structure also affect the sensitivity of trees to climate, especially in long-term prediction interval, the results of this paper may provide a theoretical basis for optimizing forest management strategies under climate change.
Evidence for genetic causal relationships between gut microbiome, metabolites, and myasthenia gravis: a bidirectional Mendelian randomization study
Authors: Sheng Dandan , Wang Song , Li Peihong , Li Jiaxin , Xiao Zheng , Lv Hui , Liu Weiping , Xiao Bo , Zhou Luo 
Published: December 2023

BackgroundMyasthenia gravis (MG) is an autoimmune disease observed to have connections with gut microbiome. We aimed to systematically assess the causal relationships between gut microbiome, gut microbiome-derived metabolites, and MG using Mendelian randomization (MR) approach.MethodsSummary-level genetic datasets from large-scale genome-wide association studies regarding 196 gut microbial taxa from the MiBioGen consortium (n=18,340), 72 derived metabolites from the TwinsUK and KORA studies (n=7,824), and antiacetylcholine receptor (AChR) antibody-positive MG (case=1,873, control=36,370) were employed for MR causal estimates. The inverse-variance weighted (IVW) method was utilized as the main analysis with MR-Egger, maximum likelihood, simple mode, and weighted median as complements. The tests of Cochran’s Q, MR-Egger intercept, Steiger, MR-PRESSO and leave-one-out were implemented for sensitivity analyses.ResultsThe forward MR estimates of IVW revealed significant causal associations of the abundance of phylum Actinobacteria, class Gammaproteobacteria, family Defluviitaleac, family Family XIII, and family Peptococcaceae with a reduced risk of MG. Conversely, the abundance of phylum Lentisphaerae, order Mollicutes RF9, order Victivallales, and genus Faecalibacterium was causally associated with an increased risk of MG. The reversed MR analysis proved negative causal correlations between the MG and the abundance of family Peptostreptococcaceae, genus Romboutsia, and genus Subdoligranulum. Regarding the derived metabolites, the IVW estimates revealed that elevated levels of beta-hydroxyisovalerate and methionine were causally associated with a decreased risk of MG, while increased levels of choline and kynurenine were linked to an increased risk of MG. Furthermore, genetically predicted MG was associated with a decreased level of cholesterol. The results obtained from complementary MR methods were similar. These findings remained robust in all sensitivity analyses.ConclusionOur MR findings support the causal effects of specific gut microbiome taxa and derived metabolites on AChR antibody-positive MG, and vice versa, yielding novel insights into prevention and therapy targets of MG. Future studies may be warranted for validation and pursuing the precise mechanisms.
Effects of participatory ‘A’rt-Based Activity On ‘Health’ of Older Community-Dwellers: results from a randomized control trial of the Singapore A-Health Intervention
Authors: Ho Andy Hau Yan , Ma Stephanie Hilary Xinyi , Tan Michael Koon Boon , Bajpai Ram , Goh Shannon Shuet Ning , Yeo Gabriellia , Teng Alicia , Yang Yilin , Galéry Kévin , Beauchet Olivier 
Published: December 2023

IntroductionThe practice of participatory art has been found to support the promotion, prevention, and management of health across the lifespan. However, clinical trials investigating the benefits of creative activities curated with and conducted in museums among older adults in East Asia remains limited.MethodsThe current research utilized a single-site, open-label randomized control trial (RCT) to evaluate a standardized Participatory ‘A’rt-Based Activity On ‘Health’ of Older Community-Dwellers – the Singapore A-Health Intervention. Outcome measures include frailty as assessed by the Centre of Excellence on Longevity Self-administered Questionnaire, wellbeing as assessed by the Warwick-Edinburgh Mental Wellbeing Scales, and quality of life as assessed by the EuroQol-5D. 112 participants aged 60 and above were randomized into the intervention group (n = 56) or an inactive control group (n = 56). Participants completed four standardized online self-administered assessments at baseline, 5-week, 9-week and 12-week follow-up during the intervention period.ResultsLinear mixed model analyses revealed no statistically significant differences between the intervention group and control group for all outcome measures. However, within the intervention group, a consistent significant reduction in frailty was observed across time from baseline to 9 weeks (MD −0.44, 95% CI −0.85 to −0.039, p = 0.032), 5-weeks to 9-weeks (MD −0.64, 95% CI −1.03 to −0.24, p = 0.002), and 5-weeks to 12-weeks (MD −0.51, 95% CI −0.91 to −0.10, p = 0.014). Moreover, the post-test mean wellbeing score in the intervention group significantly improved over time at 9-weeks (MD 1.65, 95% CI 0.09 to 3.22, p = 0.039) and 12-week (MD 2.42, 95% CI 0.67 to 4.16, p = 0.006) as compared to baseline scores.DiscussionThe findings demonstrate the potential of a structured art and museum-based intervention as a resource for promoting health among aging populations. Such benefits transcend social, cultural, and societal contexts.Clinical trial registrationClinicalTrial.gov, NCT05945589.
Development and validation of a predictive nomogram for subsequent contralateral hip fracture in elderly patients within 2 years after hip fracture surgery
Authors: Liang Jiahui , Zhang Jian , Lou Zhiyuan , Tang Xin 
Published: December 2023

PurposeContralateral hip refracture following initial hip fracture surgery is life-threatening in the elderly with high incidence and mortality. This study investigated the associated independent risk factors and established a nomogram prediction model.MethodsTotally 734 elderly patients with hip fractures who underwent surgical treatment (January 2016–December 2020) were enrolled. Following analyses on demographic variables, clinical characteristics, and laboratory examination, independent risk factors of contralateral hip fractures in the elderly were identified through the least absolute shrinkage and selection operator (LASSO) regression, and univariate and multivariate logistic regression. Patients were randomly allocated into training (n = 513) and validation sets (n = 221). A training set-based nomogram prediction model was established and assessed for predictability, discriminatory ability, and clinical applicability using the receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) in both sets.ResultsContralateral hip refractures occurred in 7.08% (52/734) patients within 2 years after surgery. Age, hemoglobin (Hb), heart disease, neurovascular disease, Parkinson’s disease (PD), Alzheimer’s disease (AD), chronic obstructive pulmonary disease (COPD), and chronic kidney disease (CKD) were independent risk factors. The nomogram prediction model had a favorable discriminatory ability, as indicated by the areas under the ROC curves (AUC): 0.906 (95% CI, 0.845–0.967) in the training set and 0.956 (95% CI, 0.927–0.985) in the validation set. The calibration curves demonstrated a good consistency between the actual subsequent contralateral hip fracture incidence and the predicted probability. The DCA of the nomogram demonstrated the model’s excellent clinical efficacy.ConclusionThe nomogram model enabled accurate individualized prediction for the occurrence of subsequent contralateral hip fracture in the elderly within 2 years after surgical treatment, which might help clinicians with precise references for appropriate perioperative management and rehabilitation education following initial hip surgery for their patients.