bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined radiomics-clinical model to predict platinum-sensitivity in advanced high-grade serous ovarian carcinoma using multimodal MRI
Authors: Na Inye , Noh Joseph J. , Kim Chan Kyo , Lee Jeong-Won , Park Hyunjin 
Published: January 2024

IntroductionWe aimed to predict platinum sensitivity using routine baseline multimodal magnetic resonance imaging (MRI) and established clinical data in a radiomics framework.MethodsWe evaluated 96 patients with ovarian cancer who underwent multimodal MRI and routine laboratory tests between January 2016 and December 2020. The patients underwent diffusion-weighted, contrast-enhanced T1-weighted, and T2-weighted MRI. Subsequently, 293 radiomic features were extracted by manually identifying tumor regions of interest. The features were subjected to the least absolute shrinkage and selection operators, leaving only a few selected features. We built the first prediction model with a tree-based classifier using selected radiomics features. A second prediction model was built by combining the selected radiomic features with four established clinical factors: age, disease stage, initial tumor marker level, and treatment course. Both models were built and tested using a five-fold cross-validation.ResultsOur radiomics model predicted platinum sensitivity with an AUC of 0.65 using a few radiomics features related to heterogeneity. The second combined model had an AUC of 0.77, confirming the incremental benefits of the radiomics model in addition to models using established clinical factors.ConclusionOur combined radiomics-clinical data model was effective in predicting platinum sensitivity in patients with advanced ovarian cancer.
A real-world pharmacovigilance study of FDA adverse event reporting system events for diazepam
Authors: He Weizhen , Wang Yang , Chen Kaiqin 
Published: January 2024

Background: Diazepam, one of the benzodiazepines, is widely used clinically to treat anxiety, for termination of epilepsy, and for sedation. However, the reports of its adverse events (AEs) have been numerous, and even fatal complications have been reported. In this study, we investigated the AEs of diazepam based on real data from the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS).Methods: Disproportionality in diazepam-associated AEs was assessed through the calculation of reporting odds ratios (RORs), proportional reporting ratios (PRRs), Bayesian confidence–propagation neural networks (BCPNNs), and gamma-Poisson shrinkage (GPS).Results: Among the 19,514,140 case reports in the FAERS database, 15,546 reports with diazepam as the “principal suspect (PS)" AEs were identified. Diazepam-induced AEs occurred targeting 27 system organ categories (SOCs). Based on four algorithms, a total of 391 major disproportionate preferred terms (PTs) were filtered out. Unexpectedly significant AEs such as congenital nystagmus, developmental delays, and rhabdomyolysis were noted, which were not mentioned in the drug insert.Conclusion: Our study identified potential signals of new AEs that could provide strong support for clinical monitoring and risk identification of diazepam.
The effect of montages of transcranial alternating current stimulation on occipital responses—a sham-controlled pilot study
Authors: Wang Jingying , Choi Kai Yip , Thompson Benjamin , Chan Henry Ho Lung , Cheong Allen Ming Yan 
Published: January 2024

BackgroundTranscranial alternative current stimulation (tACS) refers to a promising non-invasive technique to improve brain functions. However, owing to various stimulation parameters in the literature, optimization of the stimulation is warranted. In this study, the authors aimed to compare the effect of tACS electrode montages on occipital responses.MethodsIn three montage sessions (i.e., Oz-Cz, Oz-cheek, and sham), 10 healthy young adults participated, receiving 20-min 2-mA alpha-tACS. Pattern-reversal visual evoked potentials (VEPs) were measured before tACS (T0), immediately after (T20), and 20 min (T40) after tACS. Normalized changes in time-domain features (i.e., N75, P100 amplitudes, and P100 latency) and frequency-domain features [i.e., power spectral density in alpha (PSDα) and beta (PSDβ) bands] were evaluated.ResultsIn contrast to our hypothesis, the occipital response decreased immediately (T20) after receiving the 20-min tACS in all montages in terms of P100 amplitude (p = 0.01). This reduction returned to baseline level (T0) in Oz-cheek and sham conditions but sustained in the Oz-Cz condition (T40, p = 0.03) after 20 min of tACS. The effects on N75 amplitude and P100 latency were statistically insignificant. For spectral analysis, both PSDα and PSDβ were significantly increased after tACS at T20, in which the effect sustained until T40. However, there was no differential effect by montages. There was no significant difference in the occurrence of sensations across the montages. The effectiveness of the blinding is supported by the participants’ rate of guessing correctly.ConclusionThis study revealed an immediate inhibitory effect of tACS, regardless of the montages. This inhibitory effect sustained in the Oz-Cz montage but faded out in other montages after 20 min.
Social support needs of caregivers rearing children with severe motor and intellectual disabilities at home in Japan
Authors: Wakimizu Rie , Fujioka Hiroshi 
Published: January 2024

BackgroundIn Japan, recently, the number of children with severe motor and intellectual disabilities (SMID) is steadily increasing. Caregivers such as parents and family members are struggling with how to live with their children at home and in the community after discharge.ObjectiveThe current study aimed to explore the social support needs faced by caregivers while rearing children with SMID in order to identify effective means of social support in Japan.MethodsWe conducted a cross-sectional survey of the primary caregivers of children with SMID at home through special-needs elementary, junior high, and senior high schools nationwide, using a self-administered, anonymous questionnaire to investigate the actual social support needs of the caregivers. All statements of social support need were coded using Krippendorff content analysis.ResultsQuestionnaire returns were obtained from 1,176 families, and the descriptions of 1,173 families were included in the analysis. The results of the analysis showed that the needs of the caregivers consisted of seven categories.ConclusionsThe social support needs expressed by the caregivers are necessary findings for Japan today, both for the soft side, such as the development of local systems and regulations to support these families, and for the hard side, such as the increase and improvement of facilities and equipment.
COVID-19 Outcomes in Lung Transplant Recipients Following Pre-Exposure Prophylaxis With Tixagevimab-Cilgavimab During the Omicron BA.5 Surge: A Single Center Analysis
Authors: Demolder Saartje , Schaevers Veronique , Lagrou Katrien , De Munter Paul , Beeckmans Hanne , Verleden Geert M. , Godinas Laurent , Dupont Lieven J. , Van Bleyenbergh Pascal , Lorent Natalie , Vos Robin 
Published: January 2024

Lung transplant (LTx) recipients are at high risk for COVID-19 related morbidity and mortality. Data regarding pre-exposure prophylaxis (PrEP) with tixagevimab-cilgavimab in this population are scarce. We therefore evaluated COVID-19 breakthrough infections and COVID-19 related complications after PrEP in a retrospective single-center study, including 264 LTx recipients who received PrEP between June 2022 and December 2022, when Omicron BA.5 was the dominant circulating SARS-CoV-2 variant. PrEP was indicated for fully vaccinated patients with poor seroconversion (anti-S &lt;260 BAU/mL). COVID-19 breakthrough infection after PrEP occurred in 11.0% within the first 3 months, increasing to 17.4% within 6 months. Hospitalization rate rose from 27.6% to 52.9% (p = 0.046), while ICU admissions and COVID-19 mortality remained low, respectively occurring in 6.5% and 4.3% of patients with breakthrough infection within 6 months. COVID-19 breakthrough infection and associated hospitalization remained an important problem during the Omicron BA.5 surge in fully vaccinated LTx recipients with deficient seroconversion, despite PrEP with tixagevimab-cilgavimab. However, ICU admissions and COVID-19 mortality were low. Waning of neutralizing effects of PrEP and changing circulating SARS-CoV-2 variants may explain increases in COVID-19 infections and hospitalizations over time after PrEP, highlighting the need for novel, long-term effective PrEP strategies in these high-risk patients.
Wide-Angle Beam Steering Closed-Form Pillbox Antenna Fed by Substrate-Integrated Waveguide Horn for On-the-Move Satellite Communications
Authors: Ikram Muhammad , Sultan Kamel , Mobashsher Ahmed Toaha , Moosazadeh Mahdi , Abbosh Amin 
Published: January 2024

Wide-angle mechanical beam steering for on-the-move satellite communications is presented in this paper based on a closed-form pillbox antenna system. It includes three main parts: a fixed-feed part, which is a substrate-integrated waveguide (SIW) horn with an extended aperture attached to a parabolic reflector; a novel quasi-optical system, which is a single coupling slot alongside and without spacing from the parabolic reflector; and a radiating disc, which is a leaky-wave metallic pattern. To make the antenna compact, pillbox-based feeding is implemented underneath the metallic patterns. The antenna is designed based on a substrate-guided grounded concept using leaky-wave metallic patterns operating at 20 GHz. Beam scanning is achieved using mechanical rotation of the leaky-wave metallic patterns. The proposed antenna has an overall size of 340 × 335 × 2 mm3, a gain of 23.2 dBi, wide beam scanning range of 120°, from −60° to +60° in the azimuthal plane, and a low side lobe level of −17.8 dB at a maximum scan angle of 60°. The proposed antenna terminal is suitable for next-generation ubiquitous connectivity for households and small businesses in remote areas, ships, unmanned aerial vehicles, and disaster management.
Makna Panggilan Surgawi Menurut Filipi 3:10-14 dan Aplikasinya bagi Mahasiswa Teologi
Authors: Simanjuntak Elisa Septian Suandana , Sumiwi Asih Rachmani Endang , Prabowo Yusak Sigit 
Published: January 2024

In responding to heavenly calling, a person must realize that God created him as a unique person with different abilities and skills. God also calls each person to do His will uniquely and specially. Theology students face challenges that are not easy. However, they must understand and understand the heavenly calling to overcome the challenge. This research uses qualitative methods with a hermeneutic approach. This approach is done to find the meaning of heavenly vocation according to Philippians 3:10-14 and how it applies to students of theology. Theology students are people who have answered God's call to learn about God. They come from a variety of economic, cultural, and tribal backgrounds. The meaning of heavenly calling according to Philippians 3:10-14 is to forget the past, turn to the heavenly call, and run to the destination for the reward. The application of the meaning of the heavenly vocation for theological students is as follows: Theology students do not live in the past but focus on heavenly vocations; Theology students have purposeful, goal-focused lives; Theology students are persistent in discovering heavenly callings. Dalam menanggapi panggilan surgawi, seseorang harus menyadari bahwa Allah menciptakannya sebagai pribadi yang unik dengan kemampuan dan keahlian yang berbeda-beda. Allah juga memanggil setiap orang untuk menjalankan kehendak-Nya secara unik dan spesial. Mahasiswa teologi menghadapi tantangan yang tidak mudah. Namun, mereka harus mengerti dan memahami panggilan surgawi agar dapat mengatasi tantangan tersebut. Penelitian ini menggunakan metode kualitatif dengan pendekatan hermeneutik. Pendekatan ini dilakukan untuk mencari makna panggilan surgawi menurut Filipi 3:10-14 dan bagaimana aplikasinya bagi mahasiswa teologi. Mahasiswa teologi adalah orang-orang yang telah menjawab panggilan Tuhan untuk mempelajari tentang Allah. Mereka berasal dari berbagai latar belakang ekonomi, budaya, dan suku. Makna panggilan surgawi menurut Filipi 3:10-14 adalah untuk melupakan masa lalu, mengarahkan diri pada panggilan surgawi, dan berlari-lari kepada tujuan untuk memperoleh hadiah. Aplikasi makna panggilan surgawi bagi mahasiswa teologi adalah sebagai berikut: Mahasiswa teologi tidak hidup di masa lalu, tetapi fokus pada panggilan surgawi; mahasiswa teologi memiliki hidup yang terarah dan berfokus pada tujuan; mahasiswa teologi gigih dalam menemukan panggilan surgawi.
Education on The Role of Financial Literacy and Development at PT. Pawnshop
Authors: Munthe Herlin , Bayu Wulandari  , Namira Ufrida Rahmi  , Thomas Firdaus Hutahaean  , Maya Sabirina Panggabean  , Dianty Putri Purba  , Jessi Charina Sembiring  , Ribka Sari Butar-Butar  
Published: January 2024

Literasi keuangan dalah sebuah investasi jangka panjang yang sangat dibutuhkan dan bemanfaat pada masyarakat dalam mengelola dan menjaga keuangan agar dapat terjaga dan dapat dibutuhkan setiap saat yang memiliki kebutuhan yang mendesak. Adapun tujuan dari pengabdian kepada masyarakat ini untuk mengetahui bahwa peranan literasi dalam perkembangan keuangan sangat diperlukan. Pengabdian kepada masyarakat ini dilakukan oleh dosen universitas prima Indonesia fakultas ekonomi sebagai tri darama perguruan tinggi.
dilaksanakan di Kantor PT Pegadaian Gajah Mada Alamat: Jl. Gajah Mada, Sei Sikambing D, Kec. Medan Petisah, Kota Medan, Sumatera Utara 20114. Waktu pelasanaan 27 Oktober 2023. Kegiatan pengabdian yang dilakukan menggunakan metode ceramah dan diskusi. Literasi keuangan juga dapat mendukung kekayaan financial dalam pertumbuhan ekonomi. Dengan memahami literasi keuangan maka seseorang dapat menentukan produk investasi sesuai dengan kemampuan dan kebutuhn untuk jangka panjang.
Spectroscopic Distance, Mass, and Age Estimations for APOGEE DR17
Authors: Stone-Martinez Alexander , Holtzman Jon A. , Imig Julie , Nitschelm Christian , Stassun Keivan G. , Brownstein Joel R. 
Published: January 2024

Abstract
We derive distances and masses of stars from the Sloan Digital Sky Survey (SDSS) Apache Point Observatory Galactic Evolution Experiment Data Release 17 using simple neural networks. Training data for distances comes from Gaia EDR3, supplemented by literature distances for star clusters. For masses, the network is trained using asteroseismic masses for evolved stars and isochrone masses for main-sequence stars. The models are trained on effective temperature, surface gravity, metallicity, and carbon and nitrogen abundances. We found that our distance predictions have median fractional errors that range from ≈20% at low log g and ≈10% at higher log g with a standard deviation of ≈11%. The mass predictions have a standard deviation of ±12%. Using the masses, we derive ages for evolved stars based on the correspondence between mass and age for giant stars given by isochrones. The results are compiled into a Value Added Catalog called DistMass that contains distances and masses for 733,901 independent spectra, plus ages for 396,548 evolved stars.
Star Formation in the H ii Region Sh2-87: Evidence of Global Hierarchical Collapse
Authors: Biswas Siddhartha , Mondal Soumen , Hoque Ariful , Panja Alik , Baug Tapas , Das Ramkrishna 
Published: January 2024

Abstract
We present a detailed study of the Sh2-87 H ii region using a multiwavelength data set in optical to radio bands. A Herschel column density map revealed that the host cloud is filamentary in nature, and together they formed a central dense hub. The extinction map generated using near-infrared photometric data also signifies the nonuniform distribution of the cloud and reveals its filamentary nature. We estimated a sizable variable extinction over the region up to A

V
= 34.4 mag, with an average value of A

V
= 3.4 mag. Using the various infrared color–color criteria, we identified 13 Class I and 202 Class II young stellar objects (YSOs) and 22 Hα-emitting sources toward this region. Further analysis showed that the cluster is mainly composed of low-mass YSOs with a typical age of ∼3 Myr having masses in the range of 0.1–6.0 M
⊙. The identified evolved YSOs (i.e., Class II YSOs) are primarily distributed along the filaments and in the outer parts of the cloud, while the recent star formation, inferred by the presence of Class I YSOs, ionized gas, and star-forming clumps, is observed in the hub region. The overall star formation scenario in the Sh2-87 region resembles the global hierarchical collapse model of star formation, where younger massive star formation activity is expected at the central hub along with the distribution of evolved low-mass YSOs in the filaments and the outer parts of the cloud.
The JWST Discovery of the Triply Imaged Type Ia “Supernova H0pe” and Observations of the Galaxy Cluster PLCK G165.7+67.0
Authors: Frye Brenda L. , Pascale Massimo , Pierel Justin , Chen Wenlei , Foo Nicholas , Leimbach Reagen , Garuda Nikhil , Cohen Seth H. , Kamieneski Patrick S. , Windhorst Rogier A. , Koekemoer Anton M. , Kelly Pat , Summers Jake , Engesser Michael , Liu Daizhong , Furtak Lukas J. , del Carmen Polletta Maria , Harrington Kevin C. , Willner S. P. , Diego Jose M. , Jansen Rolf A. , Coe Dan , Conselice Christopher J. , Dai Liang , Dole Hervé , D’Silva Jordan C. J. , Driver Simon P. , Grogin Norman A. , Marshall Madeline A. , Meena Ashish K. , Nonino Mario , Ortiz Rafael , Pirzkal Nor , Robotham Aaron , Ryan Russell E. , Strolger Lou , Tompkins Scott , Willmer Christopher N. A. , Yan Haojing , Yun Min S. , Zitrin Adi 
Published: January 2024

Abstract
A Type Ia supernova (SN) at z = 1.78 was discovered in James Webb Space Telescope Near Infrared Camera imaging of the galaxy cluster PLCK G165.7+67.0 (G165; z = 0.35). The SN is situated 1.5–2 kpc from the host-galaxy nucleus and appears in three different locations as a result of gravitational lensing by G165. These data can yield a value for Hubble’s constant using time delays from this multiply imaged SN Ia that we call “SN H0pe.” Over the cluster, we identified 21 image multiplicities, confirmed five of them using the Near-Infrared Spectrograph, and constructed a new lens model that gives a total mass within 600 kpc of (2.6 ± 0.3) × 1014
M
⊙. The photometry uncovered a galaxy overdensity coincident with the SN host galaxy. NIRSpec confirmed six member galaxies, four of which surround the SN host galaxy with relative velocity ≲900 km s−1 and projected physical extent ≲33 kpc. This compact galaxy group is dominated by the SN host galaxy, which has a stellar mass of (5.0 ± 0.1) × 1011
M
⊙. The group members have specific star formation rates of 2–260 Gyr−1 derived from the Hα-line fluxes corrected for stellar absorption, dust extinction, and slit losses. Another group centered on a strongly lensed dusty star-forming galaxy is at z = 2.24. The total (unobscured and obscured) SFR of this second galaxy group is estimated to be (≳ 100 M
⊙ yr−1), which translates to a supernova rate of ∼1 SNe yr−1, suggesting that regular monitoring of this cluster may yield additional SNe.
Small-scale Magnetic Fields Are Critical to Shaping Solar Gamma-Ray Emission
Authors: Li 李 Jung-Tsung 融宗 , Beacom John F. , Griffith Spencer , Peter Annika H. G. 
Published: January 2024

Abstract
The Sun is a bright gamma-ray source due to hadronic cosmic-ray interactions with solar gas. While it is known that incoming cosmic rays must generally first be reflected by solar magnetic fields to produce outgoing gamma rays, theoretical models have yet to reproduce the observed spectra. We introduce a simplified model of the solar magnetic fields that captures the main elements relevant to gamma-ray production. These are a flux tube, representing the network elements, and a flux sheet, representing the intergranular sheets. Both the tube and sheet have a horizontal size of order 100 km and serve as sites where cosmic rays are reflected and gamma rays are produced. While our simplified double-structure model does not capture all the complexities of the solar-surface magnetic fields, such as Alfvén turbulence from wave interactions or magnetic fluctuations from convection motions, it improves on previous models by reasonably producing both the hard spectrum seen by Fermi Large Area Telescope at 1–200 GeV and the considerably softer spectrum seen by the High Altitude Water Cherenkov Observatory (HAWC) at near 103 GeV. We show that lower-energy (≲10 GeV) gamma rays are primarily produced in the network elements and higher-energy (≳few × 10 GeV) gamma rays in the intergranular sheets. Notably, the spectrum softening observed by HAWC results from the limited effectiveness of capturing and reflecting ∼104 GeV cosmic rays by the finite-sized intergranular sheets. Our study is important for understanding cosmic-ray transport in the solar atmosphere and will lead to insights into small-scale magnetic fields at the photosphere.
Sensibilidad al cambio de las escalas de la teoría psicológica interpersonal del suicidio de jóvenes con riesgo suicida en México
Authors: Cruz Víctor Hugo Trejo , De la Torre Alicia Edith Hermosillo , González María Guadalupe Sánchez 
Published: January 2024

La teoría interpersonal del suicidio explica el punto crítico que pasa de la ideación a la conducta suicida. A partir de la teoría se han desarrollado instrumentos que permiten identificar la presencia de variables proximales asociadas a la ideación y conducta suicida. Por otra parte, la terapia dialéctica conductual es un tratamiento con elementos de la teoría conductual, cognitivo, terapia de apoyo y elementos contextuales que muestran eficacia en tratar las variables más asociadas al riesgo suicida. Así, Se relaciona la teoría psicológica interpersonal del suicidio del suicidio con la terapia dialéctica conductual para probar si las escalas de la teoría interpersonal son sensibles al tratamiento dialéctico conducta en adolescentes con tendencias suicidas de la ciudad de Aguascalientes. Se usó la confiabilidad medida como estabilidad temporal test retest para detectar cambios en el tratamiento. Los resultados del Cuestionario de necesidades interpersonales de la propuesta son la confiabilidad medida como estabilidad temporal test retest r = 0 .50 a un mes, p < 0.05, consistencia interna α = 0.80. Muestra sensibilidad al cambio en adolescentes con riesgo suicida. Para la Escala de temeridad hacia la muerte la confiabilidad medida como estabilidad temporal test retest r = 0 .50 a un mes, p < 0.05, consistencia interna α = 0.78. Muestra sensibilidad al cambio en adolescentes con riesgo suicida. Para la Escala de eventos causales de dolor la Confiabilidad medida como estabilidad temporal test retest r = 0 .50 a un mes, p < 0.05, consistencia interna α = 0.84. Muestra sensibilidad al cambio con adolescentes en riesgo suicida. Se concluye que las escalas de la teoría psicológica interpersonal del suicidio detectan cambios a través del tiempo en las variables asociadas al riesgo suicida con tratamiento dialéctico conductual en jóvenes en riesgo suicida en México. Por lo tanto, se pueden utilizar para medir el riesgo suicida y para futuros estudios que expliquen la naturaleza del suicidio.