bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room‐Temperature Phosphorescence and Energy Transfer in Luminescent Multinuclear Platinum(II) Complexes of Branched Alkynyls
Authors: Tao Chi‐Hang , Zhu Nianyong , Yam Vivian Wing‐Wah 
Published: January 2005

AbstractA series of luminescent branched platinum(II) alkynyl complexes, [1,3,5‐{RCC(PEt3)2PtCCC6H4CC}3C6H3] (R=C6H5, C6H4OMe, C6H4Me, C6H4CF3, C5H4N, C6H4SAc, 1‐napthyl (Np), 1‐pyrenyl (Pyr), 1‐anthryl‐8‐ethynyl (HCCAn)), [1,3‐{PyrCC(PEt3)2PtCCC6H4CC}2‐5‐{(iPr)3SiCC}C6H3], and [1,3‐{PyrCC(PEt3)2PtCCC6H4CC}2‐5‐(HCC)C6H3], was successfully synthesized by using the precursors [1,3,5‐{Cl(PEt3)2PtCCC6H4CC}3C6H3] or [1,3‐{Cl(PEt3)2PtCCC6H4CC}2‐5‐{(iPr)3SiCC}C6H3]. The X‐ray crystal structures of [1,3,5‐{MeOC6H4CC(PEt3)2PtCCC6H4CC}3C6H3] and [1,8‐{Cl(PEt3)2PtCC}2An] have been determined. These complexes were found to show long‐lived emission in both solution and solid‐state phases at room temperature. The emission origin of the branched complexes [1,3,5‐ {RCC(PEt3)2PtCCC6H4CC}3C6H3] with R=C6H5, C6H4OMe, C6H4Me, C6H4CF3, C5H4N, and C6H4SAc was tentatively assigned to be derived from triplet states of predominantly intraligand (IL) character with some mixing of metal‐to‐ligand charge‐transfer (MLCT) (dπ(Pt)→π*(CCR)) character, while the emission origin of the branched complexes with polyaromatic alkynyl ligands, [1,3,5‐{RCC(PEt3)2PtCCC6H4CC}3C6H3] with R=Np, Pyr, or HCCAn, [1,3‐{PyrCC(PEt3)2PtCCC6H4CC}2‐5‐{(iPr)3SiCC}C6H3], [1,3‐{PyrCC(PEt3)2PtCCC6H4CC}2‐5‐(HCC)C6H3], and [1,8‐{Cl(PEt3)2PtCC}2An], was tentatively assigned to be derived from the predominantly 3IL states of the respective polyaromatic alkynyl ligands, mixed with some 3MLCT (dπ(Pt)→π*(CCR)) character. By incorporating different alkynyl ligands into the periphery of these branched complexes, one could readily tune the nature of the lowest energy emissive state and the direction of the excitation energy transfer.
Preferred Conformations of Peptides Containing tert‐Leucine, a Sterically Demanding, Lipophilic α‐Amino Acid with a Quaternary Side‐Chain Cβ Atom
Authors: Formaggio Fernando , Baldini Chiara , Moretto Vittorio , Crisma Marco , Kaptein Bernard , Broxterman Quirinus B. , Toniolo Claudio 
Published: January 2005

AbstractTerminally protected homopeptides of tert‐leucine, from the dimer to the hexamer, co‐oligopeptides of tert‐leucine in combination with α‐aminoisobutyric acid or glycine residues up to the hexamer level, and simple dipeptides representing known scaffolds for catalysts in asymmetric organic reactions were prepared by solution methods and fully characterized. The results of conformation analysis, performed by use of FT‐IR absorption, NMR, CD, and X‐ray diffraction techniques, indicate that this hydrophobic α‐amino acid with tetrasubstitution at the Cβ atom is structurally versatile. We show that it prefers extended or semiextended conformations, but can also be accommodated in folded structures, provided that these are biased by the presence of helicogenic residues. The current large‐scale production of Tle, combined with its conformational preferences unravelled in this work, should make this bulky, hydrophobic, Cα‐trisubstituted α‐amino acid a regular building block of any strategy seeking to tailor peptides with improved catalytic and pharmacological properties.
Stereoselective Syntheses of Dihydroxerulin and Xerulinic Acid, Anti‐Hypocholesterolemic Dyes from the Fungus Xerula melanotricha
Authors: Sorg Achim , Siegel Konrad , Brückner Reinhard 
Published: January 2005

AbstractThe title compounds 2 and 3, which are inhibitors of the biosynthesis of cholesterol, were synthesized in a convergent and perfectly stereoselective manner. In the key step, bromobutenolide 6 (obtained from levulinic acid in two steps) was coupled with either of the novel bis(stannanes) trans,cis,trans‐35 or trans,trans,trans‐35 [each accessible from 3‐(tributylstannyl)allyl alcohol (17) in four steps], giving γ‐alkylidenebutenolide trans,trans,trans‐32. This compound was coupled with iododiyne 42 or the bromoenediynoate 44 leading to dihydroxerulin (2) and to the (trimethylsilylethyl)ester 45 of xerulinic acid, respectively. Deprotection of the latter provided totally synthetic xerulinic acid (3) for the first time.
Structures and Magnetic Properties of Tetranuclear Nickel(II) Complexes with Unusual μ3‐1,1,3 Azido Bridges
Authors: Meyer Franc , Demeshko Serhiy , Leibeling Guido , Kersting Berthold , Kaifer Elisabeth , Pritzkow Hans 
Published: January 2005

AbstractPyrazolate‐based dinucleating ligands with thioether‐containing chelate arms have been used for the synthesis of a family of novel tetranuclear nickel(II) complexes [L2Ni4(N3)3(O2CR)](ClO4)2 that incorporate three azido bridges and one carboxylate (R = Me, Ph). Molecular structures have been elucidated by X‐ray crystallography in four cases, revealing Ni4 cores with a unique topology in which two of the azido ligands adopt an unusual μ3‐1,1,3 bridging mode. The compounds were further characterized by mass spectrometry, IR spectroscopy, and variable‐temperature magnetic susceptibility measurements. Magnetic data analyses indicate a combination of significant intramolecular ferromagnetic and antiferromagnetic exchange interactions that give rise to an overall ST = 0 ground state. The sign and the magnitude of the individual couplings have been rationalized in the framework of the common magnetostructural correlations for end‐to‐end and end‐on azido linkages, suggesting that these correlations also remain valid for the respective fragments of multiply bridging μ3‐1,1,3 azido ligands.
The Clusters [Ma(ECp*)b] (M=Pd, Pt; E=Al, Ga, In): Structures, Fluxionality, and Ligand Exchange Reactions
Authors: Steinke Tobias , Gemel Christian , Winter Manuela , Fischer Roland A. 
Published: January 2005

AbstractThe synthesis and structural characterization of the novel homoleptic cluster complexes [Pd2(GaCp*)2(μ2‐GaCp*)3] (1 c), [Pd3(GaCp*)4(μ2‐GaCp*)4] (2 b) and [Pd3(AlCp*)2(μ2‐AlCp*)2(μ3‐AlCp*)2] (3) (Cp*=C5Me5) are presented. Furthermore, ligand exchange reactions of these cluster complexes are explored. In contrast to the electronically and sterically saturated complexes [M(ECp*)4] (M=Ni, Pd, Pt), the new unsaturated analogues [Ma(ER)b] (E=Al, Ga, In) react with a variety of typical ligands (Cp*Al, CO, phosphines, isonitriles) to give new di‐ and tri‐substituted compounds like [Pt2(GaCp*)2(μ2‐AlCp*)3] (1 d), [PdPt(GaCp*)(PPh3)(μ2‐GaCp*)3] (4 b), or [Pd3(PPh3)3(μ2‐InCp*)(μ3‐InCp*)2] (8). The trends of the reactivity of [Ma(ER)b] as well as their fluxional behavior in solution has been elucidated by NMR spectroscopy, resulting in a mechanistic rationale for the ligand exchange reactions as well as the fluxional processes.
Metal Phosphonates Applied to Biotechnologies: A Novel Approach to Oligonucleotide Microarrays
Authors: Bujoli Bruno , Lane Sarah M. , Nonglaton Guillaume , Pipelier Muriel , Léger Jean , Talham Daniel R. , Tellier Charles 
Published: January 2005

AbstractA new process for preparing oligonucleotide arrays is described that uses surface grafting chemistry which is fundamentally different from the electrostatic adsorption and organic covalent binding methods normally employed. Solid supports are modified with a mixed organic/inorganic zirconium phosphonate monolayer film providing a stable, well‐defined interface. Oligonucleotide probes terminated with phosphate are spotted directly on to the zirconated surface forming a covalent linkage. Specific binding of terminal phosphate groups with minimal binding of the internal phosphate diesters has been demonstrated. The mixed organic/inorganic thin films have also been extended for use arraying DNA duplex probes, and therefore represent a viable general approach to DNA‐based bioarrays. Ideas for interfacing mixed organic/inorganic interfaces to other bioapplications are also discussed.
Direct asymmetric aldol reactions catalyzed by (4R)‐4‐(β‐Naphthalenyl)methoxy‐(S)‐proline
Authors: Shen Zongxuan , Chen Wuhong , Jiang Hong , Ding Yi , Luo Xiaoqing , Zhang Yawen 
Published: January 2005

AbstractA novel proline derivative, (4R)‐4‐(β‐Naphthalenyl)methoxy‐(S)‐proline, was conveniently prepared from the naturally occurring (4S)‐hydroxy‐(S)‐proline; 5 mol % of this compound efficiently catalyzes the asymmetric aldol reactions of various benzaldehydes with acetone in excess of acetone as the solvent, giving the aldol adducts in good yields with ee up to 89.8%. Chirality 17:119–120, 2005. © 2005 Wiley‐Liss, Inc.
The association of body mass index and prostate‐specific antigen in a population‐based study
Authors: Baillargeon Jacques , Pollock Brad H. , Kristal Alan R. , Bradshaw Patrick , Hernandez Javier , Basler Joseph , Higgins Betsy , Lynch Steve , Rozanski Thomas , Troyer Dean , Thompson Ian 
Published: January 2005

AbstractBACKGROUNDRecent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced‐stage disease and lower overall survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate‐specific antigen (PSA) is widely used to screen for prostate carcinoma.METHODSThe authors examined the association between BMI and PSA in a population‐based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute.RESULTSThe mean PSA value decreased in a linear fashion with an increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age.CONCLUSIONSLower levels of PSA in obese and overweight men could mask biologically consequential prostate carcinoma. Cancer 2005. Published 2005 by the American Cancer Society.
Prospective evaluation of major vascular events in patients with nonsmall cell lung carcinoma treated with cisplatin and gemcitabine
Authors: Numico Gianmauro , Garrone Ornella , Dongiovanni Vincenzo , Silvestris Nicola , Colantonio Ida , Di Costanzo Gianna , Granetto Cristina , Occelli Marcella , Fea Elena , Heouaine Abdelamid , Gasco Milena , Merlano Marco 
Published: January 2005

AbstractBACKGROUNDCancer and cisplatin‐based chemotherapy both are well recognized risk factors for coagulation disorders and thrombosis. However, vascular events (VEs) seldom are considered adverse effects of treatment and may not even be taken into account in reports of chemotherapy trials.METHODSVEs were recorded prospectively in a population of patients with nonsmall‐cell lung carcinoma (NSCLC) who were treated consecutively with cisplatin and gemcitabine using a diagnostic flow chart based on a thorough clinical examination, hematologic and coagulative parameters, and imaging assessments when appropriate.RESULTSFrom January, 2000 to January 2003, 108 patients with Stage III–IV NSCLC underwent chemotherapy and were evaluated. Overall, 22 VEs occurred in 19 patients (17.6%; 95% confidence interval [95% CI], 10.3–24.8%), including 10 arterial VEs (2 myocardial infarctions, 7 lower limb arterial thrombosis, and 1 ischemic stroke) and 12 venous VEs (3 catheter‐related upper limb VEs, 6 venous thrombosis of the lower limb, and 3 pulmonary embolisms). The cumulative proportion of VEs at 1 year after the start of chemotherapy was 22.0% (95% CI, 12.7–31.3%). Four patients died due to the VE (overall mortality, 3.7%), and 3 patients needed surgical revascularization. In the other patients, conservative medical treatment was effective. Baseline patient‐related and disease‐related characteristics of the patients with VEs did not differ significantly from the characteristics of patients without VE; liver and brain metastases were more frequent in patients with VE, although the difference did not reach statistical significance. Response rates were similar in the two groups. A double VE was detected in three patients who were given further chemotherapy after resolution of the first event.CONCLUSIONSVEs were a common finding in chemotherapy‐treated NSCLC patients. Chemotherapy itself seem to be a powerful risk factor for VE. Strategies to predict the occurrence of VEs should be developed to spare this life‐threatening toxicity. Cancer 2005. © 2005 American Cancer Society.
Differential expression of Eph receptors and ephrins in the cochlear ganglion and eighth cranial nerve of the chick embryo
Authors: Siddiqui Shazia A. , Cramer Karina S. 
Published: January 2005

AbstractThe cochleovestibular ganglion of the chick differentiates at early embryonic stages as VIIIth nerve axons enter the brainstem. The tonotopic organization of the auditory portion of the VIIIth nerve can be discerned at the time axons initially reach their brainstem targets. The mechanisms underlying this early organization are not known. Eph receptor tyrosine kinases and their ligands, the ephrins, have a demonstrated role in guiding axons to topographically appropriate locations in other areas of the nervous system. In order to begin to test whether Eph proteins have a similar role in the auditory system, we investigated the tonotopic expression of several Eph receptors and ephrins in the VIIIth nerve during embryonic ages corresponding to the initial innervation of the auditory brainstem. Expression patterns of EphA4, EphB2, EphB5, ephrin‐A2, and ephrin‐B1 were evaluated immunohistochemically at embryonic days 4 through 10. Protein expression was observed in the cochlear ganglion and VIIIth nerve axons at these ages. EphB5, ephrin‐A2, and ephrin‐B1 were expressed throughout the nerve. EphA4 and EphB2 had complementary expression patterns within the nerve, with EphA4 expression higher in the dorsolateral part of the nerve and EphB2 expression higher in the ventromedial part of the nerve. These regions may correspond to auditory and vestibular components, respectively. Moreover, EphA4 expression was higher toward the low‐frequency region of both the centrally and peripherally projecting branches of cochlear ganglion cells. Regional variation of Eph protein expression may influence the target selection and topography of developing VIIIth nerve projections. J. Comp. Neurol. 482:309–319, 2005. © 2005 Wiley‐Liss, Inc.
Distribution of L1cam mRNA in the adult mouse brain: In situ hybridization and Northern blot analyses
Authors: Horinouchi Kazuhiro , Nakamura Yukiko , Yamanaka Hiroki , Watabe Takashi , Shiosaka Sadao 
Published: January 2005

AbstractPrevious immunohistochemical analysis revealed a wide distribution of L1cam‐positive neural and nonneural structures in adult mouse brain. Although there were numerous punctate immunoreactive nerve terminals, only a few immunoreactive neuronal cell somata were present (Munakata et al. [2003] BMC Neurosci. 4:7). To explore the distribution of L1cam mRNA‐containing cells, which are interpreted to be L1cam‐producing cells, we performed in situ hybridization histochemistry with an antisense L1cam cRNA probe. L1cam mRNA was distributed widely from the olfactory bulb to the upper cervical cord with an uneven localization pattern in adult brain. All positive cell somata with silver grains after emulsion autoradiography were neuronal, and no grains were detected on nonneural cells in the present study. A high density of signals for neuronal L1cam mRNA was found in the thalamus, mammillary body, and hippocampus. In addition, strong hybridization signals were localized in various nuclei: main and accessory olfactory bulb, compact part of the substantia nigra, pontine gray matter, tegmental reticular nucleus, Edinger‐Westphal nucleus, trigeminal motor nucleus, locus coeruleus, mesencephalic trigeminal nucleus, raphe nuclei, facial nucleus, ambiguus nucleus, dorsal motor vagal nucleus, and inferior olivary nucleus. Some long projection neurons such as the pyramidal, mitral, principal neurons of several cranial nuclei, and presumably monoaminergic cells containing noradrenalin, dopamine, and serotonin, expressed high levels of L1cam. J. Comp. Neurol. 482:386–404, 2005. © 2005 Wiley‐Liss, Inc.
Acoustic stria: Anatomy of physiologically characterized cells and their axonal projection patterns
Authors: Smith Philip H. , Massie Ann , Joris Philip X. 
Published: January 2005

AbstractThe mammalian cochlear nucleus (CN) has been a model structure to study the relationship between physiological and morphological cell classes. Several issues remain, in particular with regard to the projection patterns and physiology of neurons that exit the CN dorsally via the dorsal (DAS), intermediate (IAS), and commissural stria. We studied these neurons physiologically and anatomically using the intra‐axonal labeling method. Multipolar cells with onset chopper (OC) responses innervated the ipsilateral ventral and dorsal CN before exiting the CN via the commissural stria. Upon reaching the midline they turned caudally to innervate the opposite CN. No collaterals were seen innervating any olivary complex nuclei. Octopus cells typically showed onset responses with little or no sustained activity. The main axon used the IAS and followed one of two routes occasionally giving off olivary complex collaterals on their way to the contralateral ventral nucleus of the lateral lemniscus (VNLL). Here they can have elaborate terminal arbors that surround VNLL cells. Fusiform and giant cells have overlapping but not identical physiology. Fusiform but not giant cells typically show pauser or buildup responses. Axons of both cells exit via the DAS and take the same course to reach the contralateral IC without giving off any collaterals en route. J. Comp. Neurol. 482:349–371, 2005. © 2005 Wiley‐Liss, Inc.
Comparative analysis ofCorazonin‐encoding genes (Crz's) inDrosophilaspecies and functional insights intoCrz‐expressing neurons
Authors: Choi Youn J. , Lee Gyunghee , Hall Jeffrey C. , Park Jae H. 
Published: January 2005

AbstractTo gain insight into regulatory mechanisms of tissue‐specificCorazonin(Crz) gene expression and its functions inDrosophila, we cloned theCrzgenes from fourDrosophilaspecies (D. melanogaster, D. simulans, D. erecta, andD. virilis) and performed comparative analyses ofCrzgene sequences and expression patterns using in situ hybridization and immunohistochemistry. AlthoughCrzgene sequences showed a great deal of diversity, its expression patterns in the CNS were highly conserved in theDrosophilaspecies examined here. InD. melanogasterlarva,Crzexpression was found in four pairs of neurons per cerebral lobe and in eight pairs of bilateral neurons in the ventral nerve cord; in adult, the number ofCrz‐producing neurons increased to 6–8 in the pars lateralis of each brain lobe, whereas neurons in the ventral nerve cord were no longer detectable.Crztranscripts were also found in the optic lobes; however, these mRNAs do not seem to be translated. Such adult‐likeCrzexpression patterns were established within 48 hours after pupation. Somata ofCrz‐neurons in the pars lateralis are located in the vicinity of terminals emanating from PDF‐containing pacemaking neurons, indicating a functional connection between the two peptidergic nervous systems. A subset ofCrzneurons coexpressed theperiodclock gene; however, normalCrztranscription was unaffected by central clockworks. Two pairs of ectopicCrzcells were detected in the adult brains of behaviorally arrhythmicClockJrkorcycle02mutants, suggesting that CLOCK and CYCLE proteins negatively regulateCrztranscription in a cell‐specific manner. J. Comp. Neurol. 482:372–385, 2005. © 2005 Wiley‐Liss, Inc.
Erratum: Corrêa SAL, 2004. Re‐evaluation of the afferent connections of the pituitary in the weakly electric fish Apteronotus leptorhyncus: an in vitro tract‐tracing study. J Comp Neurol 470:39‐49.
Authors: Corrêa Sônia A.L. , Zupanc Günther K.H. 
Published: January 2005

AbstractThe original article to which this Erratum refers was published in The Journal of Comparative Neurology (2004) 482: 39–49.
Comparison between the dynamic behaviour of Chua–Yang and full‐range cellular neural networks
Authors: Corinto F. , Gilli M. 
Published: January 2005

AbstractThe mathematical model of a cellular neural network (CNN) consists of a large set of coupled non‐linear differential equations that has been mainly studied through numerical simulations; the knowledge of the dynamic behaviour is essential for developing rigorous design methods and for establishing new applications. This manuscript is devoted to a comparison of the dynamic behaviours of two CNN models: the original Chua–Yang model and the full‐range model that was exploited for VLSI implementations. It is shown that, even if the two models exhibit similar properties, they are not topologically equivalent, i.e. there exist sets of identical parameters for which they present a qualitatively different dynamic behaviour. Copyright © 2003 John Wiley & Sons, Ltd.
On the simultaneous amplitude and phase approximations of wave digital lattice filters
Authors: Yaseen M. 
Published: January 2005

AbstractThe paper presents new solution for the problem of simultaneously approximating the amplitude and phase functions of wave digital lattice filters. The approximation is relying on translating the amplitude and phase specifications into corresponding specifications for the difference and sum phase functions of the two branch polynomials. As a consequence, the phase specifications for each of the two branch polynomials is determined. Accordingly, these two polynomials are generated such that the amplitude and phase functions are approximated alternatively. This means that while one of these functions is approximated, the other is fixed. By iterating this alternative process, the two functions converge to their optimal response. Copyright © 2003 John Wiley & Sons, Ltd.
A novel compact piecewise‐linear representation
Authors: Wen Chengtao , Wang Shuning , Zhang Hao , Khan Muhammad Junaid 
Published: January 2005

AbstractA new compact MAX representation for 2‐D continuous piecewise‐linear (PWL) functions is developed in this paper. The representation is promising since it can be easily generalized into higher dimensions. We also establish the explicit functional form of basis function and demonstrate that the proposed basis function is the elementary ‘building block’ from which a fully general 2‐D PWL function can be constructed. In addition, we reveal the relationship of basis function with minimal degenerate intersection and Hinging Hyperplane, which shows that the MAX model can unify Chua's canonical expression, Li's representation, lattice PWL function and Bremann's Hinging Finding Algorithm into one common theoretical framework. Copyright © 2005 John Wiley & Sons, Ltd.