bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Consciência das cores”: Natalie Kalmus e o technicolor na Grã-Bretanha
Authors: Street Sarah 
Published: November 2023

Quando o Technicolor foi visto pela primeira vez nos cinemas da Grã-Bretanha, ele foi recebido por uma onda de opiniões contraditórias, desde a queixa perplexa de que “com a tela em um ardente motim de cores é impossível se concentrar totalmente em qualquer indivíduo em particular” até a alegação de que “filmes em preto e branco em breve serão uma coisa do passado." Os modos do discurso contemporâneo a respeito da cor frequentemente abordavam o impacto das cores no público que, temia-se, poderia ser distraído por sua aparência espetacular no contexto do cinema narrativo. Para muitos diretores, diretores de fotografia e diretores de arte, contudo, a escolha da cor demonstrava o seu fascínio como registro simbólico, como uma ferramenta para apoiar a narrativa e como técnica expressiva. Este ensaio discute a chegada do Technicolor na Grã-Bretanha e o impacto que teve sobre as práticas vigentes, bem como sobre os regimes estéticos.
The individualized neural tuning model: Precise and generalizable cartography of functional architecture in individual brains
Authors: Feilong Ma , Nastase Samuel A. , Jiahui Guo , Halchenko Yaroslav O. , Gobbini M. Ida , Haxby James V. 
Published: November 2023

Abstract
Quantifying how brain functional architecture differs from person to person is a key challenge in human neuroscience. Current individualized models of brain functional organization are based on brain regions and networks, limiting their use in studying fine-grained vertex-level differences. In this work, we present the individualized neural tuning (INT) model, a fine-grained individualized model of brain functional organization. The INT model is designed to have vertex-level granularity, to capture both representational and topographic differences, and to model stimulus-general neural tuning. Through a series of analyses, we demonstrate that (a) our INT model provides a reliable individualized measure of fine-grained brain functional organization, (b) it accurately predicts individualized brain response patterns to new stimuli, and (c) for many benchmarks, it requires only 10–20 minutes of data for good performance. The high reliability, specificity, precision, and generalizability of our INT model affords new opportunities for building brain-based biomarkers based on naturalistic neuroimaging paradigms.
Clashes and agreements between regulatory agencies and courts: The influence on regulatory governance
Authors: Silva Jeovan , Guimaraes Tomas Aquino 
Published: November 2023

Literature on the operation of regulatory agencies and their interactions with the executive branch of government is well established. Much less attention has been devoted to the relationship between these agencies and the courts, especially in case of judicial review of regulators’ decisions. This paper examines how judicial review of regulatory decisions produces clashes and agreements between regulatory agencies and the courts, and the influence of these relationships on regulatory governance. The research was conducted in Brazil with 21 interviews, consisting of eight officials of six federal regulatory agencies, seven attorneys from five agencies, and six federal judges. Regulatory governance, institutional theory, and regulatory overlap were the main analytical frameworks for this research. Data was subjected to content analysis. The findings showed that judicial review plays an important role in the overlapping scopes between courts and regulatory agencies. The institutional details of regulatory governance are crucial for the regulatory bodies to function. Despite the conflicts, judges seek more coordination with regulators, because of a greater awareness of the specifics of regulatory policies. Attorneys of regulatory bodies perform a key role in the dialogue between regulators and courts, especially by bridging the gap between technical and legal protocols. Regulatory litigation provides powerful economic agents with the opportunity to obtain a successful remittance of fines, thereby diluting the regulators’ ability to enforce regulation. Points for practitioners Judicial review is the only coordinating mechanism between regulatory agencies and the courts and plays a crucial role in defining regulatory policies and in controlling administrative behavior. In the process of judicial review, regulatory bodies confront the uncertainties that mark the blurred boundaries between the roles performed by state actors and authorities in dealing with regulation. By examining the Brazilian case, the research sheds light on regulatory governance and deals with the balance of power between the judiciary and formally independent regulatory bodies. The findings indicate the value of closer dialogue between regulators and courts in a context where regulatory agencies are increasingly called upon to make important technical and social choices on highly sensitive public issues.
Development of Grapho-Narrative Neonatal Discharge Summary Format and its Comparison with Traditional Narrative Format
Authors: Murthy D Srinivasa 
Published: November 2023

Background Tiny and sick neonates stay for a longer duration in the Neonatal unit. Discharge of these neonates gets quite delayed due to typing the elaborative summary followed by other discharge formalities. This results in unpleasant experiences for most parents and some of them express the displeasure quite vocally. Apart from that, the presentation of crucial information is not uniform due to the variable levels of experience and language proficiency of the doctors who prepare discharge summaries. Primary Objective To develop a graphical format of discharge summary for neonatal patients and compare it with a traditional narrative discharge summary. Method In this study, we developed a Microsoft Excel template for a visual representation of main discharge information with scope for narration when required. We compared this with the traditional narrative summary of a hypothetical case. Results 20 pediatricians with experience in neonatal intensive care participated and filled in the scorecard after going through both formats of the discharge summary. Overall, the grapho-narrative summary scored significantly better with a median score of 114 compared to narrative summary score of 90 (p=.004). Conclusion Grapho-narrative format is quicker to prepare, provides the information as a snapshot which is preferred by pediatricians.
RoBERTa-Assisted Outcome Prediction in Ovarian Cancer Cytoreductive Surgery Using Operative Notes
Authors: Laios Alexandros , Kalampokis Evangelos , Mamalis Marios Evangelos , Tarabanis Constantine , Nugent David , Thangavelu Amudha , Theophilou Georgios , De Jong Diederick 
Published: November 2023

Introduction Contemporary efforts to predict surgical outcomes focus on the associations between traditional discrete surgical risk factors. We aimed to determine whether natural language processing (NLP) of unstructured operative notes improves the prediction of residual disease in women with advanced epithelial ovarian cancer (EOC) following cytoreductive surgery. Methods Electronic Health Records were queried to identify women with advanced EOC including their operative notes. The Term Frequency – Inverse Document Frequency (TF-IDF) score was used to quantify the discrimination capacity of sequences of words (n-grams) regarding the existence of residual disease. We employed the state-of-the-art RoBERTa-based classifier to process unstructured surgical notes. Discrimination was measured using standard performance metrics. An XGBoost model was then trained on the same dataset using both discrete and engineered clinical features along with the probabilities outputted by the RoBERTa classifier. Results The cohort consisted of 555 cases of EOC cytoreduction performed by eight surgeons between January 2014 and December 2019. Discrete word clouds weighted by n-gram TF-IDF score difference between R0 and non-R0 resection were identified. The words ‘adherent’ and ‘miliary disease’ best discriminated between the two groups. The RoBERTa model reached high evaluation metrics (AUROC .86; AUPRC .87, precision, recall, and F1 score of .77 and accuracy of .81). Equally, it outperformed models that used discrete clinical and engineered features and outplayed the performance of other state-of-the-art NLP tools. When the probabilities from the RoBERTa classifier were combined with commonly used predictors in the XGBoost model, a marginal improvement in the overall model’s performance was observed (AUROC and AUPRC of .91, with all other metrics the same). Conclusion/Implications We applied a sui generis approach to extract information from the abundant textual surgical data and demonstrated how it can be effectively used for classification prediction, outperforming models relying on conventional structured data. State-of-art NLP applications in biomedical texts can improve modern EOC care.
How Pharmacies and Retailer Shops Convey Information on Health Products to Their Customers
Authors: MacEachern Kelsey , Levine Mitchell 
Published: November 2023

Introduction Natural health products are frequently used by many people. However, many of these individuals do not discuss these products with their physicians, and instead seek information about the products from pharmacies or natural health product retailers. Previous research has shown that not all pharmacists are comfortable answering questions about these products as they receive little training in this area; natural health product retailers are unregulated and receive training at their own discretion. This study aimed to evaluate the accuracy of the information provided by pharmacies and natural health product retailers pertaining to use, adverse effects, and potential drug interactions for four currently popular products: garlic, peppermint, black licorice, and apple cider vinegar. Methods The literature surrounding these products was reviewed and compared to information provided by pharmacies and natural health product retailers. The interviews were conducted by an investigator who presented as a potential client to closely mimic real-world interactions. Statistical analysis was limited to generating proportions and 95% confidence intervals for statements made about each product. Results Overall, 10% of statements that were made regarding the uses for the four natural health products were consistent with the evidence-based literature, 40% of statements were consistent with the common use of the products, 47% of statements were inconsistent with the literature and 3% of statements reflected general opinions about the product. There was variation in the accuracy of statements depending on which product was discussed. When discussing adverse effects associated with the products 38% of statements made by pharmacists and 44% made by NHP retailers were consistent with the literature. Sixty-nine percent of pharmacists and 44% of NHP retailers correctly identified potential drug interactions for the products. Discussion The majority of statements were consistent with common use but few evidence-based statements were made and a large proportion of statements that were inconsistent with literature were made. Most interviewees required prompting to discuss adverse effects and potential drug interactions. Conclusions This study highlights a need for increased training of pharmacists and natural health product retailers to ensure that they are familiar with these popular natural health products and can provide accurate information to clients regarding use, adverse effects, and possible drug interactions.
Associations of Estradiol With Mortality and Health Outcomes in Patients Undergoing Hemodialysis: A Prospective Cohort Study
Authors: Lau Lina , Wiebe Natasha , Ramesh Sharanya , Ahmed Sofia , Klarenbach Scott , Carrero Juan-Jesus , Stenvinkel Peter , Thorand Barbara , Senior Peter , Tonelli Marcello , Bello Aminu K. 
Published: November 2023

Background: Both lower and higher estradiol (E2) levels have been associated with increased mortality among women with kidney failure. However, robust data are still lacking. Objective: We investigated the interaction of diabetes and age on linear and nonlinear associations between E2 levels, adverse outcomes, and health-related quality of life (HRQOL) in Canadian women undergoing hemodialysis (HD). Design: Population-based cohort study; data from Canadian Kidney Disease Cohort Study (CKDCS). Setting & patients: A total of 427 women undergoing HD enrolled in the CKDCS. Measurements: Baseline E2 (in pmol/L) and E2 tertiles (<38 pmol/L, 38-95 pmol/L, >95 pmol/L). Methods: Cox-proportional hazards used for all-cause and cardiovascular disease (CVD) mortality. Fine-Gray models used for incident CVD. Mixed models used for Health Utilities Index Mark 3 (HUI3), Kidney Disease Quality of Life Physical Component Scores (KDQOL12-PCS), and Mental Component Scores (KDQOL12-MCS). Results: Over a median follow-up of 3.6 (interquartile range [IQR]: 1.6-7.5) years, 250 (58.6%) participants died; 74 deaths (29.6%) were CV-related. Among 234 participants without prior CV events, 80 (34.2%) had an incident CVD event. There were no significant linear associations between E2 and all-cause mortality, CVD mortality, and incident CVD. However, E2 showed a significant concave association with all-cause mortality, but not with CVD mortality and incident CVD. Among patients aged ≥63 years, higher E2 levels were associated with lower HUI3 scores, mean difference (MD) = –0.062 per 1 – SD pmol/L, 95% confidence interval (CI) = –0.112 to –0.012, but the opposite was observed in younger patients (<63 years) in whom higher E2 levels were associated with higher HUI3 scores (MD = 0.032 per 1 – SD pmol/L, 95% CI = 0.008-0.055), Pinteraction = .045. No associations were observed among E2, KDQOL12-PCS (MD = –0.15 per 1 – SD pmol/L, 95% CI = –1.15 to 0.86), and KDQOL12-MCS (MD = –0.63 per 1 – SD pmol/L, 95% CI = –1.82 to 0.57). Limitations: Unmeasured confounding and small sample size. Conclusions: The association between E2 and all-cause mortality may be nonlinear, while no association was observed for CVD mortality, incident CVD, KDQOL12-PCS, and KDQOL12-MCS. Furthermore, the association between serum E2 and HUI3 was modified by age: Higher levels were associated with higher utility among women aged <63 years and the converse observed among older women.
Gender and Leadership: Student Perspectives on Gender Stereotypes in Round Square Schools
Authors: Hassan Kanwal Syeda , Wright Ewan 
Published: November 2023

Purpose Leadership is a valuable skill for young people to navigate transformations in modern societies and find solutions to overcome global crises. However, gender stereotypes regarding leadership persist, potentially limiting female students’ leadership aspirations, experiences, and opportunities in schools. This study explores student perspectives on gender and leadership through the conceptual lens of student voice. Design/Approach/Methods Interviews were conducted with students ( n = 93) from 12 Round Square secondary schools in 11 countries: Australia, Argentina, Chile, China, India (two schools), New Zealand, the United States, Korea, Switzerland, Tanzania, and South Africa. Findings The findings demonstrate how interest in developing and practicing leadership transcends gender. The students exhibited a deep conviction in their ability to initiate change through leadership in their schools and communities. However, female students were more cognizant of gender stereotypes regarding leadership and how this represented a barrier to realizing leadership opportunities. Originality/Value This study presents students’ perspectives on leadership and gender in contexts that appear favorable for student leadership. Primarily, it argues that although schools may seek to promote equality in leadership opportunities, female students often remain comparatively sensitive to and aware of gender stereotypes. Overall, the study highlights the complex and deeply entrenched barriers to female leadership.
Depression among older adults in an urban slum of Raipur city – a community based cross-sectional study
Authors: Kumar Mohan , Ruikar Manisha , Surya V. L. 
Published: November 2023

Abstract
Background
Older adults are at risk of chronic, silent depressive changes and the vulnerability of older adults in urban slums of India is rarely exposed. The objective of this study was to estimate the prevalence of depression among the older adults in the urban slums of India and to study the factors associated with it.

Methods
This was a community based analytical cross-sectional study conducted in Urban Field Practice Area of a tertiary care teaching hospital in Chhattisgarh, India among older adults more than or equal to 60 years of age selected using two stage, simple random sampling. The data was collected in a sample of 400 older adults by face-to-face interview using self-designed, semi-structured and pretested proforma that included validated Hindi version of Geriatric Depression Scale (GDS-15) and analyzed using SPSS v23.

Results
The prevalence of depression among older adults was 51.5% in the present study; with 27%, 12.8% and 11.8% having mild, moderate and severe depression respectively. Number of family members, living status of spouse, emotional attachment to family members, conflict in family, loneliness, social isolation, marginal friendship ties, functional status, physical exercise, active complains and diastolic BP were independent predictors of depression in older adults.

Conclusion
Early identification of depression in older adults using GDS-15 and incorporation of social isolation and functionality assessment routinely by healthcare providers for all older adults attending the outpatient departments is the need of the hour. A holistic approach to care of older adults is vital as healthcare providers seek to understand the impact of multiple, complex, interconnected factors on overall health and well-being of older adults.
Laboratory markers to identify acute histological chorioamnionitis in febrile parturients undergoing epidural analgesia: a retrospective study
Authors: Xu Chenyang , Fan Chong , Zhang Jingjing , Zeng Xin , Fan Yuru , Feng Shanwu 
Published: November 2023

Abstract
Background
This study aimed to investigate the effect of the pathological staging of acute histological chorioamnionitis (HCA) on laboratory indicators and to conduct further studies to reassess the threshold values used by clinicians to identify acute HCA in febrile parturients undergoing epidural analgesia.

Methods
A retrospective study of febrile mothers receiving epidural analgesia at Nanjing Maternal and Child Health Care Hospital from January 1, 2018 to December 31, 2018. The participants were grouped by the progression of acute HCA, and the laboratory parameters were compared between groups. The ability of C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and monocyte-leukocyte ratio (M%), alone or in combination, to identify acute HCA in febrile parturients undergoing epidural analgesia was assessed using logistic regression and ROC curves.

Results
The area under the curve (AUC) of the best logistic regression model predicting HCA climbed to 0.706 (CRP + MLR). Maternal CRP, NLR, and MLR significantly and progressively increased with the progression of acute HCA (p < 0.0001). Based on the ROC curves, the following thresholds were selected to define increased laboratory indicators for identifying acute HCA: CRP ≥ 6.90 mg/L, NLR ≥ 11.93, and MLR ≥ 0.57. In addition, the AUC of the best logistic regression model predicting HCA ≥ stage 2 was 0.710, so these inflammatory markers were more precise in predicting HCA ≥ stage 2.

Conclusion
Increased CRP (≥ 6.90 mg/L), NLR (≥ 11.93), and MLR (≥ 0.57) may help clinicians to identify early potential acute HCA in febrile parturients receiving epidural analgesia and to monitor progression to optimize clinical treatment options.

Trial registration
The study was registered in the Chinese Clinical Trial Registry on November 24, 2021 (http://www.chictr.org.cn, ChiCTR2100053554).
Angiotensin-(1–7) suppresses airway inflammation and airway remodeling via inhibiting ATG5 in allergic asthma
Authors: Xu Jianfeng , Yu Zhenyu , Liu Xueping 
Published: November 2023

Abstract
Background
Angiotensin (Ang)-(1–7) can reduce airway inflammation and airway remodeling in allergic asthma. Autophagy-related 5 (ATG5) has attracted wide attentions in asthma. However, the effects of Ang-(1–7) on ATG5-mediated autophagy in allergic asthma are unclear.

Methods
In this study, human bronchial epithelial cell (BEAS-2B) and human bronchial smooth muscle cell (HBSMC) were treated with different dose of Ang-(1–7) to observe changes of cell viability. Changes of ATG5 protein expression were measured in 10 ng/mL of interleukin (IL)-13-treated cells. Transfection of ATG5 small interference RNA (siRNA) or ATG5 cDNA in cells was used to analyze the effects of ATG5 on secretion of cytokines in the IL-13-treated cells. The effects of Ang-(1–7) were compared to the effects of ATG5 siRNA transfection or ATG5 cDNA transfection in the IL-13-treated cells. In wild-type (WT) mice and ATG5 knockout (ATG5−/−) mice, ovalbumin (OVA)-induced airway inflammation, fibrosis and autophagy were observed. In the OVA-induced WT mice, Ang-(1–7) treatment was performed to observe its effects on airway inflammation, fibrosis and autophagy.

Results
The results showed that ATG5 protein level was decreased with Ang-(1–7) dose administration in the IL-13-treated BEAS-2B and IL13-treated HBSMC. Ang-(1–7) played similar results to ATG5 siRNA that it suppressed the secretion of IL-25 and IL-13 in the IL-13-treated BEAS-2B cells, and inhibited the expression of transforming growth factor (TGF)-β1 and α-smooth muscle actin (α-SMA) protein in the IL-13-treated HBSMC cells. ATG5 cDNA treatment significantly increased the secretion of IL-25 and IL-13 and expression of TGF-β1 and α-SMA protein in IL-13-treated cells. Ang-(1–7) treatment suppressed the effects of ATG5 cDNA in the IL-13-treated cells. In OVA-induced WT mice, Ang-(1–7) treatment suppressed airway inflammation, remodeling and autophagy. ATG5 knockout also suppressed the airway inflammation, remodeling and autophagy.

Conclusions
Ang-(1–7) treatment suppressed airway inflammation and remodeling in allergic asthma through inhibiting ATG5, providing an underlying mechanism of Ang-(1–7) for allergic asthma treatment.