bluuebunny/crossref_metadata_2025_split huggingface dataset:
Вплив комплексної фармацевтичної композиції на показники системи ПОЛ-АОЗ печінки за умов експериментального метаболічного синдрому в хом’яків
Authors: Калько К. О. , Духніч Н. Ю. 
Published: November 2023

Сьогодні спосіб життя багатьох людей, який називають сучасним західним стилем життя, при­ зводить до поширеності метаболічного синдрому (МС), своєчасна профілактика та лікування якого є край важливою задачею.

Мета дослідження – встановити вплив комплексної фармацевтичної композиції (КФК) (Aevit premium) на показники системи ПОЛ­АОЗ за умов експериментального МС (ЕМС) у сирійських золотавих хом’яків.
МС у сирійських золотавих хом’яків індукували кафе­дієтою, складовими якої були суміш з про­ мислово­оброблених харчових продуктів з вмістом жирів не менше ніж 40 %. Приготовлену суміш давали тваринам з надлишком упродовж 7 тижнів (49 днів). Питну воду було замінено на 10 % р­н фруктози. Досліджувану КФК (25,8 мг/кг) і препарати порівняння метформін (60,0 мг/кг) і вітамін Е (100 мг/кг) застосовували внутрішньошлунково, починаючи з 5 тижня моделювання МС упродовж 3 тижнів (21 день), тобто, у лікувальному режимі.
Тривале перебування хом’яків групи контрольної патології на раціоні кафе­дієти призводило до розвитку МС, дисбалансу в системі ПОЛ­АОЗ, про що свідчило зниження вмісту відновленого глута­ тіону (ВГ), активності супероксиддисмутази (СОД) та каталази в тканині печінки та на тлі зростання вмісту тіобарбітурової кислоти активних продуктів (ТБК­АП). Досліджувана КФК сприяла відновлен­ню балансу в системі ПОЛ­АОЗ: збільшення вмісту ВГ, активності СОД та каталази та одночасне зменшення вмісту ТБК­АП. Встановлена здатність КФК пригнічувати оксидативний стрес та сприяти нормалізації балансу в системі ПОЛ­АОЗ обумовлена реалізацією прямої та непрямої антиокси­ дантної дії її складових (етиловими ефірами омега­3 кислот, вітаміном Е, коензимом Q10, цинком, вітаміном А, біотином, селеном), а також спроможністю останніх чинити метаболітотропну дію. За виразністю коригуючого впливу на стан системи ПОЛ­АОЗ печінки хом’яків в умовах ЕМС КФК пере­ важала препарати порівняння метформін та вітамін Е.
Отримані результати обґрунтовують доцільність застосування КФК у комплексній фармакокорек­ ції МС.
Efficacy of Combined Therapy of ACTH plus Vigabatrin Compared to ACTH Alone for Treatment of Infantile Spasm-A RCT
Authors: Sumi Samsun Nahar , Mistry Banita , Habib Md Ahsan , Chandra Mahua , Hoque Seikh Azimul , Saha Narayan Chandra 
Published: November 2023

Background: Infantile spasms (epileptic spasm) is difficult to treat and has a high morbidity. So it’s crucial to initiate an early effective therapy. ACTH, Prednisolone and Vigabatrin have shown better efficacy on cessation of spasms.
Objective: To compare the efficacy and tolerability of combined ACTH and Vigabatrin with ACTH alone in treatment of infantile spasms.
Materials & Methods: This randomized controlled trial was conducted from June, 2017 to June, 2018 at outdoor and indoor, department of Paediatric Neurology of National Institute of Neurosciences and Hospital, Dhaka. Fifty (50) patients aged 2 months to 24 months who had a clinical diagnosis of infantile spasms and hypsarrhythmia (classical or modified hypsarrhythmia) in EEG were enrolled. With parent’s written informed consent, they were randomized (1:1 by lottery method) into two groups, 25 in each. One group got ACTH only and another group got both ACTH and vigabatrin. At the end of the treatment two groups were compared regarding efficacy and safety of the drugs.
Result: The primary outcome was assessed in 50 children at 91st day. The primary outcome was cessation of spasms from 14th day to 42nd day after initiation of therapy. Cessation of spasms (between 14 to 42 days) occurred in 18 children (72%) in combination therapy and 11 children (44%) in hormonal therapy (p=0.045). Treatment response was faster on combination therapy (p=0.001). Treatment was well tolerated in both groups with few adverse effects.
Conclusion: Combination therapy of ACTH plus Vigabatrin was found better than ACTH therapy alone in cessation of infantile spasms.
BANGLADESH J CHILD HEALTH 2022; VOL 46 (1) : 14-18
Anti-tuberculosis Drug-induced Hepatitis
Authors: Karim ASM Bazlul , Musabbir Nadira 
Published: November 2023

Among the first line anti-TB drugs, INH, Rifampicin and Pyrazinamide are considered to be the most hepatotoxic drugs and cause drug induced hepatitis. Pyrazinamide causes both dose-dependent and idiosyncratic hepatitis whereas Isoniazid and Rifampicin induced hepatotoxicity are considered to be idiosyncratic. There are several risk factors for hepatotoxicity such as old age, malnutrition, genetic predisposition, HIV infection as well as chronic Hepatitis B and C infections. Anti-TB drug induced hepatitis usually occurs within 2 months after starting treatment. Patient may present with mild symptoms to severe acute hepatitis or even acute liver failure. Various guidelines have been published regarding the management of ATT and restarting anti TB drugs. This article reviews the incidence, risk factors, mechanism, diagnosis and management strategies of anti-TB drug induced hepatitis.
BANGLADESH J CHILD HEALTH 2022; VOL 46 (1) : 23-27
Idiopathic Short Stature - A Case Report
Authors: Begum Suraiya , Biswas Dhiraj Chandra 
Published: November 2023

Short stature in childhood is the most common reason for referral to pediatric endocrinologists. Idiopathic short stature is defined as ³2 SD below the corresponding mean height for a given age, sex, and population in a child with a normal birth size and normal body proportions and without evidence of any systemic, endocrine, nutritional, or chromosomal abnormalities. ISS children have normal GH responses to stimulation test and GH therapy has approved for the treatment of children with ISS. A six-year-old girl presented with not growing well in comparison to other peers since 6 months of her age. Her WAZ was -4.5 SD, HAZ was -7.7 SD, and projected height is far below parental target height. Bone age was 2-3 year and growth hormone stimulation showed normal growth hormone secretion. Here we reported a six-yearold girl diagnosed as a case of non-familial ISS and treated with growth hormone. Diagnosis of Idiopathic short stature was done by exclusion of other causes of short stature and growth hormone therapy was indicated.
BANGLADESH J CHILD HEALTH 2022; VOL 46 (1) : 28-29
Bantuan Teknis Dalam Penyusunan Rencana Anggaran Biaya (Rab) Program Kerja Desa Berbasis Dana Desa
Authors: Saputra Taufiq Yuda , Ahadian Edward Rizky , Amal Ihlasul 
Published: November 2023

Pulau MaitaraÂ merupakan salah satu kawasan wisata di Kota Tidore Kepulauan Provinsi Maluku Utara yang terletak diantara Pulau Tidore dan sekatan Pulau Ternate adalah suatu bongkahan pulau kecil yang alamiah berpenduduk 1900 jiwa denga keramahtamaan, budaya dan jiwa sosialnya yang tinggi serta menyimpang kekayaan yang potensial untuk pengembangan sebagai kawasan wisata. Dengan demikian, berdasarkan potensi yang ada di daerah ini, kegiatan dariÂ PKM ini sangat berpeluang besar sebaggai upaya peningkatan ekonomiÂ di tingkat keluarga guna mewujudkan kesejahteraan desa. Dalam pelaksanaannya, dana desa mulai dialokasikan dalam APBN sejak 2015 sebesar Rp. 20,76 triliun. Dalam periode 2015-2020, alokasi dana desa melalui APBN telah mencapai Rp. 328,07 triliun. Pagu Dana Desa Tahun 2022 telah ditetapkan sebesar Rp. 68 triliun dan dialokasikan kepada 74.961 desa di 434 kabupaten/kota se-Indonesia. Berdasarkan pantauan, selama tahun 2021, secara umum permasalahan dana desa dapat dilihat dari aspek perencanaan, pengelolaan dan pertanggungjawaban. Hal ini menunjukkan bahwa pendampingan dan pengawasan pengelolaan dana desa belum berjalan dengan optimal. Oleh karena itu, peningkatan pembinaan, pendampingan dan pengawasan pengelolaan dana desa menjadi kewajiban yang harus DilakukanKata Kunci: Dana Desa, Program Kerja
Sosialisasi dan Edukasih Zona Selamat Sekolah Pada Murid Kelas V SD Mononutu Kota Ternate
Authors: M. Nurmaiyasa , Gaus Abdul , Amalia Ema 
Published: November 2023

Pendidikan mengenai keselamatan berlalu lintas harus ditanamkan sejak dini di kalangan anak-anak sekolah. Untuk itu Pemerintah pun memberi perhatian khusus terhadap anak-anak usia sekolah ini yang ditandai dengan inisiatif untuk menggulirkan program Zona Selamat Sekolah (ZoSS) yaitu dengan memberikan edukasi serta dukungan sarana dan prasarana dalam penyelenggaraan perlindungan anak. Lokasi yang dipilih dalam pengabdian kepada masyarakat ini adalah sekolah dasar yang lokasi sekolahnya masuk dalam kategori rawan lalu lintas, lokasinya berada pada SD Mononutu kota TernateÂ Ketersedian Zona Selamat Sekolah (ZoSS) di SD Mononutu belum berfungsi maksimal, ini terlihat Â masih adanya terjadi kecelakaan ringan maupun berat yang terjadi di seputaran ruas jalan sekolah, dari hasil sosialisasi pemaparan zona selamat sekola yang di sampikan ke pada siswa SD kelas V hampir seluruh murid kelas V belum paham dan mengerti tentang atribut dan rambu-rambu zona selamat sekolah serta fungsinya-fungsi dari marka dan rambu-rambu yang ada di lingkungan ruas jalan sekolah yang berada di lokasi sekolah mereka, hasil dari sosialisasi Â dan edukasi Zona Selamat Sekolah diharapkan siswaseluruh siswa SD Mononuti dapat memahami dan mengerti tentang edukasi fungsi dan kegunaan zona selamat sekolah, serta memberikan rasa aman kepada para murid yang akan menyeberang di jalan. DiharapkanÂ dengan adanya kegiatan PKM dapat membantu penerapan tentang zona selamat sekolah dan dapat meminimalisir kecelakaan lalu lintas, yang ada di ruas jalan depan sekolah mereka.Kata Kunci: Zona, Selamat, Sekolah, Murid
Kesiapan Perawat Gawat Darurat Rumah Sakit Umum Daerah Kabupaten Bandung Dalam Menghadapi Bencana
Authors: Lestari Diah Ayu Sri 
Published: November 2023

Bencana merupakan peristiwa yang mengancam serta mengganggu kehidupan masyarakat. Respon cepat dalam situasi tanggap bencana merupakan hal penting yang dilakukan oleh seorang first responder untuk meminimalisir korban jiwa. Kesiapan perawat merupakan hal krusial, termasuk kesiapan perawat sebagai first responder bencana dalam fase tanggap darurat. Sementara dalam pelaksanaannya, perawat tidak melakukan implementasi secara maksimal. Hal ini diperkuat oleh sebuah penelitian yang mengatakan bahwa perawat tidak memiliki persiapan yang baik dalam penanganan bencana. Penelitian ini bertujuan untuk mengetahui kesiapan perawat gawat darurat RSUD Kabupaten Bandung dalam menghadapi bencana.
Penelitian ini menggunakan metode deskriptif kuantitatif dengan jumlah populasi sebanyak 33 perawat IGD RSUD Soreang dan RSUD Majalaya dengan menggunakan teknik total sampling. Penelitian menggunakan instrumen Emergency Preparedness Information Questionnaire (EPIQ) yang membagi kesiapan perawat menjadi 8 dimensi dengan jumlah 24 item pernyataan diukur menggunakan skala likert dan hasil pengukurannya dihitung dengan menggunakan analisis deskriptif.
Hasil penelitian ini menunjukkan bahwa sebanyak 85% perawat memiliki kesiapan sedang dalam menghadapi bencana, dengan skor mean tertinggi (3,16) berada pada dimensi sistem komando kejadian dan terendah (2,80) berada pada populasi khusus.
Kesiapan perawat berada dalam kesiapan sedang berarti dikatakan sudah cukup siap terlebih dalam sistem komando kejadian. Meskipun ada dimensi yang masih kurang, yaitu populasi khusus. Hal ini dapat dikarenakan penanganan pada populasi khusus paling banyak memerlukan perhatian pada perawatannya dan kegagalan dalam penanganannya akan berdampak kurang baik bagi kehidupan mereka selanjutnya. Maka untuk memenuhi kebutuhan tersebut dapat dilakukan program pelatihan penanganan populasi khusus.

Kata Kunci : Bencana, EPIQ, Kesiapan Perawat
Pengaruh Metoda Ceramah Dan Demonstrasi Terhadap Pengetahuan Kader Kesehatan Mengenai Perawatan Infeksi Saluran Nafas Akut (Ispa) Dan Deteksi Dini Pneumonia Pada Balita di Cikijing Kabupaten Majalengka
Authors: Adistie Fanny , Nurhidayah Ikeu , Mardhiyah Ai , Hendrawati Sri , Maryam Nenden Nur Asriyani 
Published: November 2023

Di Indonesia, penyakit infeksi saluran pernapasan akut (ISPA) menjadi fokus program kesehatan terutama pneumonia karena merupakan penyebab utama mortalitas anak balita di Indonesia. Maka dari itu, mengoptimalkan peran kader kesehatan dapat membantu masyarakat untuk dapat melakukan perawatan ISPA dengan benar serta mendeteksi adanya tanda bahaya dari ISPA tersebut seperti pneumonia. Tujuan dari penelitian ini adalah untuk mengidentifikasi pengaruh metode ceramah dan demonstrasi terhadap pengetahuan kader kesehatan mengenai perawatan ISPA dan deteksi dini pneumonia pada anak. Penelitian ini menggunakan desain penelitian pre-eksperimental dengan one group pretest-posttest. Responden pada penelitian ini sebanyak 39 kader kesehatan, dengan intervensi yang dilakukan adalah pelatihan pada kader kesehatan mengenai perawatan ISPA dan deteksi dini pneumonia pada anak dengan menggunakan metode ceramah serta demonstrasi. Hasil penelitian didapatkan sebelum dilakukan intervensi pengetahuan kader kesehatan menunjukkan 44,4% responden memiliki pengetahuan yang cukup dan sebagian besar responden 55,6% responden memiliki pengetahuan yang kurang. Setelah dilakukan intervensi pengetahuan kader kesehatan menunjukkan sebagian besar 77,8% responden memiliki pengetahuan yang baik dan hanya 22,2% responden yang memiliki pengetahuan yang cukup. Hasil Uji dengan Wilcoxon didapatkan pengaruh yang signifikan dari metode ceramah dan demonstrasi terhadap pengetahuan kader kesehatan mengenai perawatan ISPA dan deteksi dini pneumonia pada anak (p = 0.000). Implikasi dari penelitian ini adalah metode ceramah yang dikombinasikan dengan demonstrasi terbukti efektif untuk meningkatkan pengetahuan para akder kesehatan, maka dari itu metode pada intervensi ini dapat digunakan dalam memberikan pelatihan kepada para kader kesehatan.
Establishing a three-dimensional scaffold model of hepatoblastoma
Authors: Weigl Elena Johanna , Demir Salih , Schmid Tanja , Hotes Alina , Muensterer Oliver , Kappler Roland 
Published: November 2023

Introduction: Emerging technologies such as three-dimensional (3D) cell culture and the generation of biological matrices offer exciting new possibilities in disease modelling and tumour therapy. The paucity of laboratory models for hepatoblastoma (HB), the most prevalent malignant liver tumour in children, has hampered the identification of new treatment options for HB patients. We aimed to establish a reliable 3D testing platform using liver-derived scaffolds and HB cell lines that reflect the heterogeneous biology of the disease so as to allow reproducible preclinical research and drug testing.Methods: In a sequence of physical, chemical and enzymatic decellularisation techniques mouse livers were stripped off all cellular components to obtain a 3D scaffold. HB cell lines were then seeded onto these scaffolds and cultivated for several weeks.Results: Our newly generated biological scaffolds consist of liver-specific extracellular matrix components including collagen IV and fibronectin. A cultivation of HB cell lines on these scaffolds led to the formation of 3D tumour structures by infiltration into the matrix. Analyses of drug response to standard-of-care medication for HB showed reliable reproducibility of our stocked models.Discussion: Our HB models are easy-to-handle, producible at large scale, and can be cryopreserved for ready-to-use on-demand application. Our newly generated 3D HB platform may therefore represent a faithful preclinical model for testing treatment response in precision cancer medicine.
Novel venous balloon for compliance measurement and stent sizing in a post-thrombotic swine model
Authors: Wang Mengjun , Lu Xiao , Han Ling , Wang Amy M. , Raju Seshadri , Kassab Ghassan S. 
Published: November 2023

Objective: Real-time accurate venous lesion characterization is needed during endovenous interventions for stent deployment. The goal of this study is to validate a novel device for venoplasty sizing and compliance measurements.Methods: A compliance measuring sizing balloon (CMSB) uses real-time electrical conductance measurements based on Ohm’s Law to measure the venous size and compliance in conjunction with pressure measurement. The sizing accuracy and repeatability of the CMSB system were performed with phantoms on the bench and in a swine model with an induced post thrombotic (PT) stenosis in the common femoral vein of swine.Results: The accuracy and repeatability of the CMSB system were validated with phantom bench studies of known dimensions in the range of venous diameters. In 9 swine (6 experimental and 3 control animals), the luminal cross-sectional areas (CSA) increased heterogeneously along the PT stenosis when the CMSB system was inflated by stepwise pressures. The PT stenosis showed lower compliance compared to the non-PT vein segments (5 mm2 vs. 10 mm2 and 13 mm2 at a pressure change of 40 cm H2O). Compliance had no statistical difference between venous hypertension (VHT) and Control. Compliance at PT stenosis, however, was significantly smaller than that at Control and VHT (p &lt; 0.05, ANOVA).Conclusion: The CMSB system provides accurate, repeatable, real-time measurements of CSA and compliance for assessment of venous lesions to guide interventions. These findings provide the impetus for future first-in-human studies.
Quercetin improves and protects Calu-3 airway epithelial barrier function
Authors: DiGuilio K. M. , Rybakovsky E. , Valenzano M. C. , Nguyen H. H. , Del Rio E. A. , Newberry E. , Spadea R. , Mullin J. M. 
Published: November 2023

Introduction: In light of the impact of airway barrier leaks in COVID-19 and the significance of vitamin D in COVID-19 outcomes, including airway barrier protection, we investigated whether the very common dietary flavonoid quercetin could also be efficacious in supporting airway barrier function.Methods: To address this question, we utilized the widely used airway epithelial cell culture model, Calu-3.Results: We observed that treating Calu-3 cell layers with quercetin increased transepithelial electrical resistance while simultaneously reducing transepithelial leaks of 14C-D-mannitol (Jm) and 14C-inulin. The effects of quercetin were concentration-dependent and exhibited a biphasic time course. These effects of quercetin occurred with changes in tight junctional protein composition as well as a partial inhibition of cell replication that resulted in decreased linear junctional density. Both of these effects potentially contribute to improved barrier function. Quercetin was equally effective in reducing the barrier compromise caused by the pro-inflammatory cytokine TNF-α, an action that seemed to derive, in part, from reducing the elevation of ERK 1/2 caused by TNF-α.Discussion: Quercetin improved Calu-3 barrier function and reduced TNF-α-induced barrier compromise, mediated in part by changes in the tight junctional complex.
Establishment of the mechanism of purification and levigation of green chemistry-assisted biocomposites of red ochre (Gairika): synthesis, characterization, and antibacterial, prebiotic, antioxidant, and antacid activities of the traditional Ayurvedic medicine Laghu Sutashekhara Rasa
Authors: Charde Vaibhav , Kumar Vijay , Dane Ganesh , Gandhi Yashika , Soni Hemant , Jagtap Chandrashekar , Mishra Sujeet K. , Shakya Santosh K. , Singh Arjun , Singh Ravindra , Sharma Bhagwan S. , Khanduri Shruti , Srikanth Narayanam , Acharya Rabinarayan , Webster Thomas J. 
Published: November 2023

Gairika (red ochre) has a long history of influencing human civilization. Gairika is a rich source of nutrients used for reproductive and brain health. Gairika is mentioned as an antacid drug in Indian Ayurvedic medicine under Laghu Sutashekhara Rasa (LSR). However, a detailed study on LSR has not been reported to date. In the present study, LSR was prepared, and a pharmaceutical SOP (standardization procedure) was reported to obtain batch-to-batch reproducibility. LSR was characterized using FTIR, XRD, SEM-EDX, and TGA analyses. LSR was tested in vitro for its antacid activity. Advanced instrumentation revealed that LSR formation produced symmetrical particles (5–8 µm) with kaolin, kaolinite, quartz, goethite, and hematite, along with the phytoconstituents of Goghrita (clarified cow’s butter), Shunthi, and Nagawalli, as confirmed by GC-MS/MS analysis. The FTIR study revealed the formation of a chelating complex of goethite and hematite along with their phytoconstituents. XRD analysis confirmed the presence of kaolin, kaolinite, quartz, goethite, and hematite. Using in vitro antacid experiments, LSR and Shunthi demonstrated significant antacid activity as compared to antacid drugs and standards in the market, such as CaCO3. The DPPH assay revealed IC50 values of 12.16 ± 1.23 mg/mL, which is 0.0029 of Trolox-equivalent antioxidant activity. The inhibition (18 ± 4 mm) against pathogens (S. aureus, E. coli, P. aeruginosa, and B. subtilis) and the prominent growth of gut microbiota-supported strains (S. boulardii, L. paracasei, and L. plantarum) observed on LSR formulation were indicative of LSR application as a prebiotic. Here, the mechanism of purification and levigation mentioned in the classical literature of LSR was established. Overall, purification of Gairika with cow ghee and levigation with Nagawalli may enhance the solubility, bioavailability, and shelf-life of LSR through hydration and co-crystallization mechanisms. This is the first comprehensive report on the pharmaceutical validation of LSR and its characterization. The results of the present study could contribute to the development and reliable reproduction of LSR and the utility of environmental red ochre as a medicine in combination with Shunthi (Zingiber officinale Roxb.), as prescribed under Indian Ayurvedic medicine.
Association between the variability of non-high-density lipoprotein cholesterol and the neutrophil-to-lymphocyte ratio in patients with coronary heart disease
Authors: Chen Yifan , Zhang Sisi , Tao Yecheng , Hu Wenyi , Li Duanbin , Shen Xiaohua , Li Ya , Lin Maoning , Zhang Wenbin , Liu Xianglan , Xie DaQi 
Published: November 2023

BackgroundLowering lipid variability may be a potential strategy for improving the inflammatory state in patients with coronary heart disease (CHD). This study investigated the association between the variability of non-high-density lipoprotein cholesterol (non-HDL-C) and the neutrophil-to-lymphocyte ratio (NLR).MethodsThis study enrolled 2,711 CHD patients subjected to percutaneous coronary intervention (PCI). During the 1-year follow-up period after PCI, the variability of non-HDL-C was assessed using standard deviation (SD), coefficient of variation (CV), and variability independent of mean (VIM). NLR was calculated as the ratio of absolute neutrophil count to absolute lymphocyte count. The relationship between the non-HDL-C variability and the average NLR level during follow-ups was examined using a linear regression analysis.ResultsThe mean age of the patients was 64.4 ± 10.8 years, with 72.4% being male. The average NLR level was 2.98 (2.26–4.14) during the follow-up (1 year after PCI). The variability of non-HDL-C was 0.42 (0.26–0.67) for SD, 0.17 (0.11–0.25) for CV, and 0.02 (0.01–0.03) for VIM. A locally weighted scatterplot smoothing curve indicates that the average levels of NLR increased with increasing variability of non-HDL-C. Regardless of the variability assessment method used, non-HDL-C variability was significantly positively associated with the average NLR level during follow-ups: SD [β (95% CI) = 0.681 (0.366–0.996)], CV [β (95% CI) = 2.328 (1.458–3.197)], and VIM [β (95% CI) = 17.124 (10.532–23.715)]. This association remained consistent across subgroups stratified by age, gender, diabetes, and hypertension.ConclusionThe variability of non-HDL-C was positively associated with NLR in patients with CHD, suggesting that reducing non-HDL-C variability may improve the low-grade inflammatory state in CHD patients.