bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review and meta-analysis: the efficiency of bacteriophages previously patented against pathogenic bacteria on food
Authors: Romero-Calle Danitza Xiomara , de Santana Vinicius Pereira , Benevides Raquel Guimarães , Aliaga Maria Teresa Alvarez , Billington Craig , Góes-Neto Aristóteles 
Published: October 2023

AbstractFood-borne diseases are a global public health issue with 1 in 10 people falling ill after eating contaminated food every year. In response, the food industry has implemented several new pathogen control strategies, such as biotechnological tools using the direct application of bacteriophages for biological control. We have undertaken a systematic review and meta-analysis that evaluated the efficiency of patented phages as a biological control for food-borne pathogens and determined the physical–chemical characteristics of the antimicrobial effect. Included and excluded criteria was developed. Included criteria: Phage patent files with an application in biological control on food and scientific articles and book chapters that used phages patented for food biological control. Excluded criteria: Patent documents, scientific articles, and book chapters that included phage therapy in humans, animals, and biological control on plants but did not have an application on food were not considered in our study. The systematic analysis identified 77 documents, 46 scientific articles, and 31 documents of patents and 23 articles was included in the meta-analysis. Listeria monocytogenes and Salmonella sp. comprised most of the targets identified in the screening, so that we focused on these strains to do the meta-analysis. There are a total of 383 and 192 experiments for Listeria and Salmonella phages for quantitative data analysis.Indexing databases for the bibliographic search (Scopus, Web of Science (WoS) and PubMed (Medline) were addressed by an automated script written in Python 3 Python Core Team (2015) and deposited on GitHub (https://github.com/glenjasper).A random-effects meta-analysis revealed (i) significant antimicrobial effect of Listeria phages in apple, apple juice, pear, and pear juice, (ii) significant antimicrobial effect of Salmonella phages in eggs, apple, and ready-to-eat chicken, (iii) no heterogeneity was identified in either meta-analysis, (iv) publication bias was detected for Listeria phages but not for Salmonella phages. (v) ListShield and Felix01 phages showed the best result for Listeria and Salmonella biological control, respectively, (vi) concentration of phage and bacteria, time and food had significant effect in the biological control of Listeria, (vii) temperature and time had a significant effect on the antimicrobial activity of Salmonella phages. The systematic review and meta-analyses to determine the efficiency of bacteriophages previously patented against pathogenic bacteria on dairy products, meat, fruits and vegetables. Besides, the discovering of key factors for efficacy, so that future applications of phage biotechnology in foods can be optimally deployed.
Systematic oxidative stress indices predicts prognosis in patients with urothelial carcinoma of the upper urinary tract after radical nephroureterectomy
Authors: Liu Jianyong , Lai Shicong , Wu Pengjie , Wang Jiawen , Wang Jianye , Wang Jianlong , Zhang Yaoguang 
Published: October 2023

Abstract
Background
Oxidative stress plays an important role in the occurrence and development of malignancy. However, the relationship between oxidative stress and upper urinary tract urothelial carcinoma (UTUC) prognosis remains elusive. This study aimed to evaluate the prognostic value of systematic oxidative stress indices as a predictor of patient outcomes in UTUC after radical nephroureterectomy.

Methods
Clinical data for 483 patients with UTUC who underwent radical nephroureterectomy were analyzed. Patients were categorized according to an optimal value of systematic oxidative stress indices (SOSIs), including fibrinogen (Fib), gamma-glutamyl transpeptidase (γ-GGT), creatinine (CRE), lactate dehydrogenase (LDH) and albumin (ALB). Kaplan–Meier analyses were used to investigate associations of SOSIs with overall survival (OS) and progression-free survival (PFS). Moreover, associations between SOSIs and OS and PFS were assessed with univariate and multivariate analyses.

Results
High values of Fib, γ-GGT, CRE, and LDH, and low values of ALB were associated with reduced OS. SOSIs status correlated with age, tumor site, surgical approach, hydronephrosis, tumor size, T stage, and lymph node status. The Kaplan–Meier survival analysis showed a significant discriminatory ability for death and progression risks in the two groups based on SOSIs. Multivariate Cox proportional hazards models showed that SOSIs were an independent prognostic indicator for OS (p = 0.007) and PFS (p = 0.021). SOSIs and clinical variables were selected to establish a nomogram for OS. The 1-, 3-, and 5-year AUC values were 0.77, 0.78, and 0.81, respectively. Calibration curves of the nomogram showed high consistencies between the predicted and observed survival probability. Decision curve analysis curves showed that the nomogram could well predict the 1‐year, 3-year, and 5‐year OS.

Conclusions
SOSIs are an independent unfavorable predictor of OS and PFS in patients diagnosed with UTUC undergoing RNU. Therefore, incorporating SOSIs into currently available clinical parameters may improve clinical decision-making.
The impact of conflict on food security: evidence from household data in Ethiopia and Malawi
Authors: Muriuki James , Hudson Darren , Fuad Syed 
Published: October 2023

Abstract
Background
Violent conflicts threaten food security and household welfare in sub-Saharan Africa. While a more robust understanding of the causal relationship between food security and conflict is vital in mitigating food insecurity and bolstering peace prospects, only limited research exists on this topic, especially at the household level where estimations are more empirically challenging given data constraints and identification issues. Our analysis utilizes a newly developed and novel difference-in-differences model developed by de Chaisemartin and D’Haultfoeuille (2020) to determine the causal relationship between violent conflicts and food security in two sub-Saharan African countries—Malawi and Ethiopia using household-level data from the World Bank’s Household Living Standards Measurement Survey.

Results
Our results suggest that exposure to violent conflict on average decreases the food consumption score (FCS) by 6.84 units, which corresponds to a 16.13% reduction in FCS. With respect to individual countries, Malawi shows the largest effect-size, with the FCS decreasing by 10.54 units (equivalent to a 20.22% reduction in FCS). In Ethiopia, the causal estimate was slightly smaller at − 4.32 (equivalent to a 11.67% reduction in FCS) although the baseline food security status was lower relative to Malawi. Disaggregated analyses show that the effect-size can be several orders of magnitude larger when conflict is experienced simultaneously with natural shocks. Robustness checks using different iterations of propensity score matching generate comparable causal estimates and reinforce the overall findings.

Conclusions
The findings help improve our understanding of a broader issue by providing new direct and granular evidence regarding the relationship between conflict and food security using household data. The results hold implications for aid and humanitarian efforts to help households facing food insecurity stemming from violence and other factors.
ASENN: attention-based selective embedding neural networks for road distress prediction
Authors: Philip Babitha , Xu Zhenyu , AlJassmi Hamad , Zhang Qieshi , Ali Luqman 
Published: October 2023

AbstractThis study proposes an innovative neural network framework, ASENN (Attention-based Selective Embedding Neural Network), for the prediction of pavement deterioration. Considering the complexity and uncertainty associated with the pavement deterioration process, two fundamental frameworks, SEL (Selective Embedding Layer) and MDAL (Multi-Dropout Attention Layer), are combined to enhance feature abstraction and prediction accuracy. This approach is significant while analyzing the pavement deterioration process due to the high variability of the contributing deterioration factors. These factors, represented as tabular data, undergo filtering, embedding, and fusion stages in the SEL, to extract crucial features for an effective representation of pavement deterioration. Further, multiple attention-weighted combinations of raw data are obtained through the MDAL. Several SELs and MDALs were combined as basic cells and layered to form an ASENN. The experimental results demonstrate that the proposed model outperforms existing tabular models on four road distress parameter datasets corresponding to cracking, deflection, international roughness index, and rutting. The optimal number of cells was determined using different ablation settings. The results also show that the feature learning capabilities of the ASENN model improved as the number of cells increased; however, owing to the limited combination space of feature fields, extreme depths were not preferred. Furthermore, the ablation investigation demonstrated that MDAL can improve performance, particularly on the cracking dataset. Notably, compared with mainstream transformer models, ASENN requires significantly less storage and achieves faster execution speed.
Increased ACL direct insertion coverage provided more positive biomechanical effects on graft and bone tunnel during knee flexion: a simulation study
Authors: Xiao Yang , Liang Zhaoxin , Shen Shiwen , Liu Fei , Hu Hai , Chen Bin 
Published: October 2023

AbstractPurposeFlattened femoral tunnels were recently applied in anatomical single‐bundle anterior cruciate ligament (ACL) reconstruction. Little is known about the biomechanical effect of such changes during knee flexion. The aim of the present simulation study was to assess the effect of altered ACL direct insertion coverage on the biomechanics of the graft and bone tunnel.MethodsFive finite element (FE) models, including a round femoral tunnel and four progressively flattened rounded rectangular femoral tunnels, were established to represent the ACL reconstructions. In vivo knee kinematics data obtained from the validated dual fluoroscopic imaging techniques controlled the FE models to simulate lunge motions. The maximal principal stress of the graft and the volume of equivalent strain within 1000–3000 microstrain (V1000‐3000) of the cancellous bone were subsequently calculated at 0°, 30°, 60° and 90° of knee flexion.ResultsA lower stress state on the graft and a more beneficial strain state on the cancellous bone were observed when the femoral tunnel better covered the ACL direct insertion. The average maximal principal stress of each model were 3.93 ± 0.60 MPa, 3.82 ± 0.54 MPa, 3.43 ± 0.44 MPa, 3.45 ± 0.44 MPa and 3.05 ± 0.43 MPa, respectively. The average V1000‐3000 of the cancellous bone of each model were 179.06 ± 89.62 mm3, 221.40 ± 129.83 mm3, 247.57 ± 157.78 mm3, 282.74 ± 178.51 mm3 and 295.71 ± 162.59 mm3, respectively. Both the stress and strain values exhibited two peaks during the flexion simulation. The highest value occurred at 30° of flexion, and the second highest value occurred at 90° of flexion.ConclusionsIncreased ACL direct insertion coverage provided more positive biomechanical effects after anatomical single‐bundle ACL reconstruction during knee flexion.
Qualifications and supports for teaching teams in state-funded preschool in the United States
Authors: Weisenfeld Georgenne G. , Hodges Kate Schellie , Copeman Petig Abby 
Published: October 2023

AbstractIn the United States, state-funded preschool is a critical component of both K-12 public education and the early childhood education and care system. In 2021, 44 states and the District of Columbia operated 63 school/center-based preschool programs serving over 1.3 million children. The vast majority of state-funded preschool programs require two adults in each classroom: typically, a lead teacher and an assistant teacher, with an expectation for team teaching. This paper examines the trends and variations in state policies that address the qualifications requirements, compensation, and professional development supports for preschool lead and assistant teachers in state-funded preschool programs that provide a foundation for supporting a culture of collective success and potential quality of the classroom.
World Cafés as a participatory approach to understanding research agendas in primary care with underserved communities: reflections, challenges and lessons learned
Authors: McGrath Carmel , Kennedy Mari-Rose , Gibson Andy , Musse Samira , Kosar Zahra , Dawson Shoba 
Published: October 2023

Abstract
Background
Certain communities are underserved by research, resulting in lower inclusion rates, under researched health issues and a lack of attention to how different communities respond to health interventions. Minoritised ethnic groups are often underserved by research and services. They experience health inequalities and face significant barriers to accessing health services. It is recognised that new approaches are needed to reach underserved communities and make research more relevant. The purpose of this work was to utilise World Cafés, a participatory method, to explore research agendas with diverse communities.

Methods
Two World Cafés were conducted as research agenda setting activities with individuals from minoritised ethnic communities in Bristol, UK. World Café 1 explored Black and Asian women’s perspectives about supporting mental health. World Café 2 with men from the Somali community, focused on prostate cancer. Community members co-developed the focus and questions of each World Café and were also instrumental in recruiting individuals to the sessions and facilitating discussions, including translation. Audio and written records were made of the discussions and from these key issues about each topic were identified, and a visual representation of the discussion was also generated. These were shared with participants to check for accuracy.

Results
Community members identified a range of issues that are important to them in relation to mental health and prostate cancer, including barriers to help seeking and accessing primary and secondary care, ideas for service improvements and a need for health information that is accessible and culturally relevant.

Conclusions
World Cafés are a flexible method that can be successfully adapted for research agenda setting with individuals from minoritised ethnic communities. The role of community members in co-developing the focus of sessions, recruiting community members and co-facilitating sessions is crucial to this success. The discussions at both World Cafés provided a rich insight into the experiences of participants in relation to the topics mental health and prostate cancer and identified issues that are important to these communities that will be followed-up with communities, researchers and clinicians to co-develop research and service improvement strategies.
Refugee COVID-19 protocol adherence and NGO staff perceptions: paternalism and power in humanitarian assistance
Authors: Karaoglu Ezgi , Nawyn Stephanie J. , Qaji Natalynn , Qaji Natalie , Nashwan Ayat J. , Gasteyer Stephen 
Published: October 2023

AbstractDuring the COVID-19 pandemic, humanitarian NGOs have instituted safety protocols intended to reduce the risk of spreading infection during services to refugees. But those protocols are not always followed, and how staff attribute refugee non-adherence reveals underlying power dynamics in humanitarian assistance which can shape how they approach improving adherence in order to enhance effective service provision to the refugees. Using the data from 1466 interviews conducted with 468 different NGO staff in Türkiye, Jordan, and Lebanon, this study exhibits how paternalistic rhetoric operated in humanitarianism during the initial stages of the pandemic. While staff attribute the non-adherence of refugees to essential refugee culture and sometimes “immoral” character, they attribute their own non-adherence to morally neutral situational factors. Some NGO staff even perceived the refugees as incapable of complying with the safety protocols without assistance. While the literature on paternalism focuses on North/South power dynamics between service providers and refugees, our data show that these dynamics also exist in South-South humanitarian interventions where both the service providers and the refugees are from the region and have similar cultural backgrounds.
Economic Evaluation of a Nonmedical Financial Assistance Program on Missed Treatment Appointments Among Adults With Cancer
Authors: Biddell Caitlin B. , Spees Lisa P. , Trogdon Justin G. , Kent Erin E. , Rosenstein Donald L. , Angove Rebekah S.M. , Rogers Cindy D. , Wheeler Stephanie B. 
Published: October 2023

PURPOSE We retrospectively evaluated the clinical and economic impact of a program providing nonmedical financial assistance on missed treatment appointments among patients receiving cancer treatment at a large, Southeastern public hospital system. MATERIALS AND METHODS We used patient electronic health records, program records, and cancer registry data to examine the impact of the program on rates of missed (or no-show) radiation therapy and infusion chemotherapy/immunotherapy appointments in the 180 days after treatment initiation. We used propensity weighting to estimate the effect of the program, stratified by treatment appointment type (radiation therapy, infusion chemotherapy/immunotherapy). We developed a decision tree–based economic model to conduct a cost-consequence analysis from the health system perspective in a hypothetical cohort over a 6-month time horizon. RESULTS Of 1,347 patients receiving radiation therapy between 2015 and 2019, 53% (n = 715) had ≥1 no-shows and 28% (n = 378) received program assistance. Receipt of any assistance was associated with a 2.1 percentage point (95% CI, 0.6 to 3.5) decrease in the proportion of no-shows, corresponding to a 51% decrease in the overall mean no-show proportion. Under the current funding model, the program is estimated to save the health system $153 in US dollars per missed appointment averted, relative to not providing nonmedical financial assistance. Of the 1,641 patients receiving infusion chemotherapy/immunotherapy, 33% (n = 541) received program assistance, and only 14% (n = 223) had ≥1 no-shows. The financial assistance program did not have a significant effect on no-show proportions among infusion visits. CONCLUSION This study used a novel approach to retrospectively evaluate a nonmedical financial assistance program for patients undergoing active cancer treatment. Findings support investment in programs that address patients' nonmedical financial needs, particularly for those undergoing intensive radiation therapy.
Exploring Stakeholders' Perspectives on Implementing Universal Germline Testing for Colorectal Cancer: Findings From a Clinical Practice Survey
Authors: Rodgers-Fouche Linda , Arora Sanjeevani , Ricker Charité , Li Dan , Farooqi Maheen , Balaguer Francesc , Dominguez-Valentin Mev , Guillem Jose G. , Kanth Priyanka , Liska David , Melson Joshua , Mraz Kathryn A. , Shirts Brian H. , Vilar Eduardo , Katona Bryson W. , Hodan Rachel 
Published: October 2023

PURPOSE New guidelines recommend considering germline genetic testing for all patients with colorectal cancer (CRC). However, there is a lack of data on stakeholders' perspectives on the advantages and barriers of implementing universal germline testing (UGT). This study assessed the perspectives of members of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC) regarding the implementation of UGT for patients with CRC, including readiness, logistics, and barriers. METHODS A cross-sectional survey was sent to 317 active members of CGA-IGC. The survey included sections on demographics, clinical practice specialty, established institutional practices for testing, and questions pertaining to support of and barriers to implementing UGT for patients with CRC. RESULTS Eighty CGA-IGC members (25%) participated, including 42 genetic counselors (53%) and 14 gastroenterologists (18%). Forty-seven (59%) reported an academic medical center as their primary work setting, and most participants (56%) had more than 10 years of clinical practice. Although most participants (73%) supported UGT, 54% indicated that changes in practice would be required before adopting UGT, and 39% indicated that these changes would be challenging to implement. There was support for both genetics and nongenetics providers to order genetic testing, and a majority (57%) supported a standardized multigene panel rather than a customized gene panel. Key barriers to UGT implementation included limited genetics knowledge among nongenetics providers, time-consuming processes for obtaining consent, ordering tests, disclosing results, and lack of insurance coverage. CONCLUSION This study demonstrates wide support among hereditary GI cancer experts for implementation of UGT for patients with CRC. However, alternative service delivery models using nongenetics providers should be considered to address the logistical barriers to UGT implementation, particularly the growing demand for genetic testing.
How to be an authentic leader, 1. Understanding authentic leadership
Authors: Thomas Vinice 
Published: October 2023

Strong leaders with an approach that supports, empowers and inspires staff are vital to the delivery of quality care and services for patients and service users. Every failing identified in the NHS, and the subsequent reviews examining them have pointed to the failing of leadership to maintain the standards of care, protection and quality required for clinical services eg Mid Staffordshire ( Francis, 2013 ) and the Shipman Inquiries ( Smith, 2003 ). Over the next few months, we will be looking at several leadership styles and how these can impact on patients, staff and health and social care. In simple terms, a leader influences others (either directly, or by delegating) to carry out a specific action or set of objectives. The essence of followers and followership is considered by authors as an essential aspect of understanding leadership and the importance of the interaction between the two parties ( Winston and Patterson, 2006 ). Authentic leadership is one of the leadership styles that is categorised as relational eg it focuses on building relationships with others, and it is also seen as a positive leadership form (Malila et al, 2017). Authentic leaders are considered to be key in creating improved nursing and organisational outcomes through promoting a positive emotional wellbeing and such leadership is associated with lower staff turnover ( Laschinger et al, 2016 ; Lee et al, 2019 ). Furthermore, authentic leadership has been linked with improved patient outcomes ( Boamah et al, 2017 ).