bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sfumato as a Metaphor for Creating a Common Understanding in Complex Projects
Authors: Gotcheva Nadezhda 
Published: October 2023

AbstractSfumato painting technique is proposed as an artistic metaphor for creating a shared understanding about safety and risk in complex safety-critical multi-stakeholder projects. The aim is to illuminate a mindset and suggest approaches for softening potentially detrimental effect of sharp dysfunctional boundaries between and within different project parties, which might impair quality of communication, coordination, and collaboration and impact safety.
State of the Evidence on Climate (Im)mobilities and Well-Being
Authors: Bergmann Jonas 
Published: October 2023

AbstractIn this chapter, I assess the existing evidence with relevance to the research questions. Based on the review of the empirical knowledge on climate-immobility linkages as well as of the objective and subjective well-being impacts of (climate) (im)mobilities, I draw implications for this study. The review yielded a breadth of evidence on migration, but implications on immobility are uncertain. First, the evidence suggests that internal migration can have mixed effects on people’s OWB. Key determinants include how voluntarily and how prepared migrants can leave; under what conditions they move and into which contexts of reception they arrive; the time passed since settling; and how intersectional factors shape (dis-)advantages throughout the process. Some gains seem possible under positive conditions of moving but even then, high costs will likely accompany these gains. Finally, the effects on sending communities depend on the strength of translocal ties; remittances are one central effect but should not detract from others, including those on social relationships. Second, SWB effects greatly depend on context. As in other poor countries, most involuntary migrants and rural-to-urban migrants may be bound to lose present SWB. Only a few, specific groups of migrants might lose SWB shortly before migrating, but then make gains beyond the prior set range. It is possible that climate migrants’ SWB will remain worse than that of stayers and locals. Additionally, negative feelings are likely for stayers, but may be accompanied by positive feelings and gains in satisfaction, especially for poorer recipients of remittances in areas where migration is common. Strong stressors, including those related to climate change, could negatively shape outlooks to the future, but personal-level factors may create buffering effects. More positive views of the future are possible where migrants perceive opportunities, agency, and pathways to desired futures, including for next generations. Critically, if the affected people end up holding more hope or fear could have feedback effects on OWB. Third, the review shows that migrants’ OWB and SWB may converge or diverge, stressing the need to analyze both jointly. Finally, present SWB and views of the future can also converge to varying degrees depending on external and personal-level factors. This study intends to add insights into the array of possible outcomes.
Comparative Analysis and Overarching Propositions
Authors: Bergmann Jonas 
Published: October 2023

AbstractIn this chapter, I comparative and assess the full empirical evidence from three case studies on the highlands, rainforest, and coastal zone of Peru. By doing so, I identify resemblances and divergences regarding the well-being impacts of climate (im)mobilities and mechanisms of action. Findings show that the studied (im)mobilities led to a range of total well-being outcomes, with more net-negative than net-positive results on average. More often than not, significant structural constraints set hard limits on people’s well-being pathways. Foremost, weak governance as well as development and climate inequalities, together with other structures of neglect and marginalization, created an uneven distribution of opportunities to migrate in the first place, to move or stay under tolerable conditions, and to subsequently preserve or enhance well-being. Simultaneously, people’s well-being trajectories also depended on the varying nature and impacts of hazards, which shaped their baseline resources to different extents. Severe abrupt or late-stage gradual climate impacts created particularly heavy well-being burdens for subsequent (im)mobilities. Moreover, the analysis demonstrates that most farmers had very limited agency to address climate impacts or circumvent state failures and other structural hurdles, which further lowered their chances of maintaining or enhancing their well-being. Few affected people managed to use their limited agency to achieve small advances within their constrained room to maneuver. Using the full empirical evidence base generated in this book, I conclude by distilling nine key propositions regarding the well-being impacts of climate (im)mobilities that can be applied beyond the contexts studied here and tested in future research.
Venlafaxine’s therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis
Authors: Lense X.M. , Hiemke C. , Funk C.S.M. , Havemann-Reinecke U. , Hefner G. , Menke A. , Mössner R. , Riemer T.G. , Scherf-Clavel M. , Schoretsanitis G. , Gründer G. , Hart X.M. 
Published: October 2023

Abstract
Introduction
The selective serotonin and norepinephrine reuptake inhibitor venlafaxine is among the most prescribed antidepressant drugs worldwide and, according to guidelines, its dose titration should be guided by drug-level monitoring of its active moiety (AM) which consists of venlafaxine (VEN) plus active metabolite O-desmethylvenlafaxine (ODV). This indication of therapeutic drug monitoring (TDM), however, assumes a clear concentration/effect relationship for a drug, which for VEN has not been systematically explored yet.

Objectives
We performed a systematic review and meta-analysis to investigate the relationship between blood levels, efficacy, and adverse reactions in order to suggest an optimal target concentration range for VEN oral formulations for the treatment of depression.

Methods
Four databases (MEDLINE (PubMed), PsycINFO, Web of Science Core Collection, and Cochrane Library) were systematically searched in March 2022 for relevant articles according to a previously published protocol. Reviewers independently screened references and performed data extraction and critical appraisal.

Results
High-quality randomized controlled trials investigating concentration/efficacy relationships and studies using a placebo lead-in phase were not found. Sixty-eight articles, consisting mostly of naturalistic TDM studies or small noncontrolled studies, met the eligibility criteria. Of them, five cohort studies reported a positive correlation between blood levels and antidepressant effects after VEN treatment. Our meta-analyses showed (i) higher AM and (ii) higher ODV concentrations in patients responding to VEN treatment when compared to non-responders (n = 360, k = 5). AM concentration-dependent occurrence of tremor was reported in one study. We found a linear relationship between daily dose and AM concentration within guideline recommended doses (75–225 mg/day). The population-based concentration ranges (25–75% interquartile) among 11 studies (n = 3200) using flexible dosing were (i) 225–450 ng/ml for the AM and (ii) 144–302 ng/ml for ODV. One PET study reported an occupancy of 80% serotonin transporters for ODV serum levels above 85 ng/ml. Based on our findings, we propose a therapeutic reference range for AM of 140–600 ng/ml.

Conclusion
VEN TDM within a range of 140 to 600 ng/ml (AM) will increase the probability of response in nonresponders. A titration within the proposed reference range is recommended in case of non-response at lower drug concentrations as a consequence of VEN’s dual mechanism of action via combined serotonin and norepinephrine reuptake inhibition. Drug titration towards higher concentrations will, however, increase the risk for ADRs, in particular with supratherapeutic drug concentrations.
Interventions to Improve Patient Care on Surgical Ward Rounds: A Systematic Review
Authors: He Reuben , Bhat Sameer , Varghese Chris , Rossaak Jeremy , Keane Celia , Baraza Wal , Wells Cameron I. 
Published: October 2023

AbstractBackgroundWard rounds are an essential component of surgical and perioperative care. However, the relative effectiveness of different interventions to improve the quality of surgical ward rounds remains uncertain. The aim of this systematic review was to evaluate the efficacy of various ward round interventions among surgical patients.MethodsA systematic literature search of the MEDLINE (OVID), EMBASE (OVID), Scopus, Cumulative Index of Nursing and Allied Health (CINAHL), and PsycInfo databases was performed on 7 October 2022 in accordance with PRISMA guidelines. All studies investigating surgical ward round quality improvement strategies with measurable outcomes were included. Data were analysed via narrative synthesis based on commonly reported themes.ResultsA total of 28 studies were included. Most were cohort studies (n = 25), followed by randomised controlled trials (n = 3). Checklists/proformas were utilised most commonly (n = 22), followed by technological (n = 3), personnel (n = 2), and well‐being (n = 1) quality improvement strategies. The majority of checklist interventions (n = 21, 95%) showed significant improvements in documentation compliance, staff understanding, or patient satisfaction. Other less frequently reported ward round interventions demonstrated improvements in communication, patient safety, and reductions in patient stress levels.ConclusionsUse of checklists, technology, personnel, and well‐being improvement strategies have been associated with improvements in ward round documentation, communication, as well as staff and patient satisfaction. Future studies should investigate the ease of implementation and long‐term durability of these interventions, in addition to their impact on clinically relevant outcomes such as patient morbidity and mortality.
Thulium fiber laser vs Ho:YAG in RIRS: a prospective randomized clinical trial assessing the efficacy of lasers and different fiber diameters (150 µm and 200 µm)
Authors: Taratkin Mark , Azilgareeva Camilla , Petov Vladislav , Morozov Andrey , Ali Stanislav , Babaevskaya Diana , De Coninck Vincent , Korolev Dmitry , Akopyan Gagik , Scoffone Cesare Marco , Chinenov Denis , Androsov Alexander , Fajkovic Harun , Lifshitz David , Traxer Olivier , Enikeev Dmitry 
Published: October 2023

Abstract
Introduction
The aims of the study: (1) to compare the Super Pulse Thulium Fiber Laser (SP TFL) and the holmium: yttrium–aluminium-garnet (Ho:YAG) lasers in retrograde intrarenal surgery (RIRS); (2) to compare the efficacy of SP TFL laser fibers of different diameters (150 μm and 200 μm).

Methods
A prospective randomized single-blinded trial was conducted. Patients with stones from 10 to 20 mm were randomly assigned RIRS in three groups: (1) SP TFL (NTO IRE-Polus, Russia) with fiber diameter of 150 μm; (2) SP TFL with 200-μm fiber; and (3) Ho:YAG (Lumenis, USA) with 200-μm fiber.

Results
Ninety-six patients with kidney stones were randomized to undergo RIRS with SP TFL using a 150-μm fiber (34 patients) and a 200-μm fiber (32 patients) and RIRS with Ho:YAG (30 patients). The median laser on time (LOT) in the 200-μm SP TFL group was 9.2 (6.2–14.6) min, in 150-μm SP TFL—11.4 (7.7–14.9) min (p = 0.390), in Ho:YAG—14.1 (10.8–18.1) min (p = 0.021). The total energy consumed in 200-μm SP TFL was 8.4 (5.8–15.2) kJ; 150-μm SP TFL − 10.8 (7.3–13.5) kJ (p = 0.626) and in Ho:YAG—15.2 (11.1–25.3) kJ (p = 0.005).

Conclusions
Irrespective of the density, RIRS with SP TFL laser has proven to be both a safe and effective procedure. Whilst the introduction of smaller fibers may have the potential to reduce the duration of surgery, SP TFL results in a reduction in the LOT and total energy for stone ablation in RIRS compared with Ho:YAG.
Greater adherence to the Healthy Nordic Food Index is associated with lower all-cause mortality in a population-based sample from northern Germany
Authors: Stürmer Paula , Ratjen Ilka , Weber Katharina Susanne , Övermöhle Cara , Liedtke Tatjana Patricia , Waniek Sabina , Strathmann Eike Andreas , Lieb Wolfgang 
Published: October 2023

Abstract
Purpose
Dietary pattern scores reflecting a high intake of beneficial food groups were associated with reduced mortality risk. Data on associations of such dietary pattern scores in population-based samples from northern Germany are lacking. Therefore, we examined the association of three dietary pattern scores with all-cause mortality in a moderate-sized prospective sample from northern Germany.

Methods
The study sample comprised 836 participants (43.8% females, median age 62.4 years). Based on a validated, self-administered Food Frequency Questionnaire, the dietary scores Dietary Approaches to Stop Hypertension (DASH), Modified Mediterranean Diet Score (MMDS), and Healthy Nordic Food Index (HNFI) were calculated. Cox proportional hazard regression models, adjusted for age, sex, body mass index, waist to hip ratio, education, smoking status, total energy intake, and physical activity, were used to separately relate DASH, MMDS, and HNFI to all-cause mortality.

Results
During a median follow-up period of 11 years, 93 individuals died. While DASH and MMDS scores were not associated with all-cause mortality, greater adherence to HNFI was associated with lower mortality hazards (HR: 0.47 [95% CI 0.25–0.89] when comparing the highest score quartile to the lowest; HR: 0.79 [95% CI 0.64–0.98] for HNFI modeled as a 1-Standard Deviation increment). Among different HNFI components, higher intake of oats and cereals displayed the most conclusive association with all-cause mortality (HR: 0.59 [95% CI 0.38–0.91] when comparing high and low intake).

Conclusion
In an elderly general population sample from northern Germany, we observed greater adherence to HNFI to be associated with lower all-cause mortality.
The effect of age on outpatient pediatric procedural sedation with intranasal dexmedetomidine and oral midazolam
Authors: Zhou Xiaqing , Zhao Jialian , Tu Haiya , Chen Kunwei , Hu Yaoqin , Jin Yue 
Published: October 2023

Abstract
Procedural sedation for diagnostic examination is a common practice in children. The study aims to analyze the sedative effect and safety of intranasal dexmedetomidine combined with oral midazolam in outpatient pediatric procedural sedation across different age groups and to assess the incidence of sedation failure. From February 2021 to September 2021, children who underwent procedural sedation were retrospectively enrolled. The children were divided into 4 groups based on age: the infant group (0 to 1 year old), toddler group (1 to 3 years old), preschool group (3 to 6 years old), and school-age group (6 to 12 years old). Two-mcg/kg intranasal dexmedetomidine and 0.5-mg/kg oral midazolam were used for sedation. The sedation success rate after rescue, sedation success rate, onset time of sedation, and the sedation time were recorded. The incidence of adverse events and the risk factors for sedation failure were also analyzed. A total of 4758 patients were identified. After exclusion, 3149 patients were ultimately enrolled. The combination of 2-mcg/kg intranasal dexmedetomidine and 0.5-mg/kg oral midazolam resulted in a total success rate of 99.7% and a sedation success rate of 91.4%. The sedation success rate varied among the four groups: 90.2% in the infant group, 93.1% in the toddler group, 92.7% in the preschool group, and 78.4% in the school-age group. The sedation success rate was significantly lower in the school-age group compared to the other three groups (P < 0.001). The onset time of sedation was shorter in infant (22 min, IQR: 18–28 min, P < 0.001) and longer in the school-age group (30 min, IQR: 25–35 min, P < 0.05). Additionally, the infants had a longer sedation time (110 min, IQR: 90–135 min, P < 0.001) and a higher rate of delayed recovery (27.5%, all P < 0.001). The incidence of adverse events was low (4.70%), which bradycardia (2.03%) being the most common. Age (0–1 year and > 6 years), weight, ASA class II, and history of failed sedation were identified as risk factors of sedation failure.
Conclusion: Intranasal administration of 2-mcg/kg dexmedetomidine combined with oral administration of 0.5-mg/kg midazolam was found to be efficient and safety for pediatric procedural sedation. Different age groups of children exhibited distinct sedation characteristics, and age was identified as a risk factor affecting the efficacy of sedation.

What is Known:• Procedural sedation for diagnostic examination is a common practice in children.• The combination of dexmedetomidine with midazolam can improve sedative effects.

What is New:• The success rate of sedation using a combination of 2-mcg/kg intranasal dexmedetomidine and 0.5-mg/kg oral midazolam was significantly lower in school-age children as compared to infants, toddlers, and preschoolers.• The onset time of sedation increased with age, and the sedation time was found to be longer in infant patients.
Genetic variability of Haemonchus contortus isolates in small ruminants from slaughterhouses in Bangladesh
Authors: Mannan Muhammad Abdul , Chowdhury Sharmin , Hossain Mohammad Alamgir , Kabir Md Hazzaz Bin 
Published: October 2023

AbstractHaemonchus contortus is a blood-sucking gastrointestinal nematode that infects all ruminants and causes significant economic losses in production. Characterizing the genetic variability of H. contortus populations is crucial for understanding patterns of disease transmission and developing effective control strategies against haemonchosis. This study aimed to identify the genetic variability of H. contortus isolates in small ruminants from slaughterhouses in Bangladesh. During January to December 2015, 400 abomasa samples were collected and 186 were found to be positive for Haemonchus. A 321-bp fragment of the second internal transcribed spacer (ITS-2) of nuclear ribosomal DNA and an 800-bp fragment of the mitochondrial nicotinamide dehydrogenase subunit-4 gene (nad4) were amplified using polymerase chain reaction (PCR) and directly sequenced. The results showed 10 genotypes (ITS-2) and 45 haplotypes (nad4) among the 186 worms. The sequences were 98.5 to 100% identical to reference sequences from the GenBank database. ITS-2 sequence analysis revealed four nucleotide substitutions at positions 30, 41, 42, and 216. There was one transition (C/T) at position 42 and three transversions (C/A at position 30, G/C at position 41, and T/A at position 216). The nad4 gene sequences showed 15 substitutions, all of which were transitions. The pairwise distance of ITS-2 between H. contortus populations ranged from 0.005 to 1.477. The nucleotide diversity (μ) among the populations was 0.009524 using ITS-2 and 0.00394 using nad4. This study indicated low genetic deviation among H. contortus populations in Bangladesh.
An early Cambrian post-rift basin within the Baltica–Iapetus passive margin (north-central Scandinavian Caledonides)
Authors: Greiling Reinhard O. , Kathol Benno , Kumpulainen Risto A. 
Published: October 2023

AbstractField data from recent geological mapping over a major part of the north-central Scandinavian Caledonides combined with published information give a detailed view of early Cambrian basin successions, comprising the Gärdsjön formation (Gf; Jämtland supergroup) in the Lower Allochthon and autochthonous equivalents (Dividal Group). The Gf comprises ten units of sandstone and siltstone or mudstone (Gf I—X, > 300 m thick). Green siltstones with red layers (Gf VI, c. 521 to 519 Ma) and green–grey siltstones at the top (Gf X, c. 516.5 to 513.5 Ma) are regional key horizons. Gf V, VI, VII, IX, and X deposition may be related to eustatic events. Restoration of Caledonian shortening reveals a major “Hornavan-Vattudal basin” (HVB; > 330 km NW–SE, > 400 km NE-SW) between the Grong–Olden culmination in the S and the Akkajaure–Tysfjord culmination in the N. Published zircon ages imply the latter separated the HVB from those shed from the Timan orogen in the N. The eastern basin margin straddles the present Caledonian erosional margin. Basement highs identified here within the Nasafjället, Bångonåive, and Børgefjellet “basement” windows define the western margin. They separate the HVB from the outer shelf towards the Iapetus Ocean in the W. The onset of sedimentation is time-related with E–W extension at c. 544–534 Ma. NNE–SSW-directed extension occurs after c. 518 Ma, perhaps related with Timan late-orogenic extension. The HVB is distinctly younger (c. 535–513.5 Ma) than Rodinia break-up and Iapetus ocean formation (> 550 Ma), comparable with post-rift basins in inner parts of modern passive margins.
Graphical Abstract
Ventricular CSF proteomic profiles and predictors of surgical treatment outcome in chronic hydrocephalus
Authors: Rostgaard Nina , Olsen Markus Harboe , Lolansen Sara Diana , Nørager Nicolas Hernandez , Plomgaard Peter , MacAulay Nanna , Juhler Marianne 
Published: October 2023

Abstract
Background
By applying an unbiased proteomic approach, we aimed to search for cerebrospinal fluid (CSF) protein biomarkers distinguishing between obstructive and communicating hydrocephalus in order to improve appropriate surgical selection for endoscopic third ventriculostomy vs. shunt implants. Our second study purpose was to look for potential CSF biomarkers distinguishing between patients with adult chronic hydrocephalus benefitting from surgery (responders) vs. those who did not (non-responders).

Methods
Ventricular CSF samples were collected from 62 patients with communicating hydrocephalus and 28 patients with obstructive hydrocephalus. CSF was collected in relation to the patients’ surgical treatment. As a control group, CSF was collected from ten patients with unruptured aneurysm undergoing preventive surgery (vascular clipping).

Results
Mass spectrometry-based proteomic analysis of the samples identified 1251 unique proteins. No proteins differed significantly between the communicating hydrocephalus group and the obstructive hydrocephalus group. Four proteins were found to be significantly less abundant in CSF from communicating hydrocephalus patients compared to control subjects. A PCA plot revealed similar proteomic CSF profiles of obstructive and communicating hydrocephalus and control samples. For obstructive hydrocephalus, ten proteins were found to predict responders from non-responders.

Conclusion
Here, we show that the proteomic profile of ventricular CSF from patients with hydrocephalus differs slightly from control subjects. Furthermore, we find ten predictors of response to surgical outcome (endoscopic third ventriculostomy or ventriculo-peritoneal shunt) in patients with obstructive hydrocephalus.