bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Neurological Sequela: Pontine Infarct Conducing to Millard-gubler Syndrome
Authors: Vemana Hema Ratna Sai Lakshmi , Ahmed Nisar , Chikkala Bhagya Aruna , Gogulamanda Rupa Lavanya , Kandregula Priyanka , Nalli Minisha , Yanamadala Pavan Kumar 
Published: November 2023

Background: Ventral Pontine Syndrome, likewise called Millard Gubler Syndrome (MGS) or Facial abducens hemiplegia disorder is a neurodegenerative problem that is described by one-sided lesions influencing the basal piece of the caudal pons including fascicles of the abducens and the facial nerves and the pyramidal lot filaments. Clinical findings incorporate fringe Facial Nerve Paralysis and neuromuscular shortcoming or loss of motion of at least one appendage. This is an exceptionally uncommon condition assessed to influence 1 out of 10, 00, 000. Men (aged 40-60 years) are bound to foster the condition than ladies.
Case Nuances: A 45-year-old male patient had intensely passed a-sided facial droop 4 days prior to presenting with weakness on the left half of his upper and lower appendages. He, along with his attender likewise referenced that he had recently had a 2-minute loss of cognizance, discombobulation, and vertical shifting of the right eye both when he lost his consciousness. He had low serum Vitamin D and was determined to have Millard Gubler Condition as an Infarct in the pontine locale was recognized in imaging, and was dealt with restoratively and with Non-intrusive treatment.
Discussion: Millard-Gubler disorder might cause cerebellar ataxia if the paramedian pontine dead tissue region somewhat expands horizontally, influencing the centre cerebellar peduncles. Detached pontine localized necrosis might have decent progress whenever analyzed and overseen early.
Conclusion: MGS is typically found in instances of brainstem cancers, drain, tuberculoma, parasitic contamination, Ischemic stroke secondary to impediment of the basilar supply route, and injury.
The Healing Flora of Konjuh Mountain in Bosnia and Herzegovina
Authors: Huseinović Samira , Ahmetović Elma , Bektić Sanida , Selimović Samela , Memić Senad 
Published: November 2023

The mountain of Konjuh is characterized by a landscape of high aesthetic value with significant diversity in biological, geomorphological, and hydrological aspects. This, combined with its cultural-historical heritage, religious and traditional values, provides the foundation for educational, ecotourism, and sports-recreational tourism activities, as well as for visitor enjoyment and the development of economic activities. Located in the northeastern part of Bosnia and Herzegovina, Konjuh, along with Ozren, Javor, and Javornik, forms part of the chain of peripheral (higher) mountains, which, together with Trebavac and Majevica, represent the transition from the Dinaric mountain system to the vast Pannonian plain. The average elevation of the mountain is 1,000 meters. The Tuzla Canton government has passed a law declaring a portion of Konjuh Mountain, covering an area of 8,016 hectares, as a Cultural Heritage site of Bosnia and Herzegovina.
The aim of this study was to systematically inventory medicinal plant species at seven sites on Konjuh Mountain in three municipalities (Kladanj, Živinice, and Banovići) at different altitudes (from 560 to 1,100 meters), classify medicinal plant species based on taxonomic and ecological attributes, and create phytocenological field records.
During the research, 109 medicinal plant species were identified, including endangered and endemic species. The taxonomic structure of the families of medicinal plants on Konjuh Mountain revealed the presence of 43 families, with the most represented being representatives of the Lamiaceae family at 13.76%, Asteraceae at 11.92%, Fabaceae at 7.33%, and Plantaginaceae at 5.50%. A phytogeographical analysis of the medicinal plant flora identified 11 areal types and groups. An analysis of the biological spectrum of flora in all habitats indicates the presence of six primary life form types, with hemicryptophytes (H) being dominant, accounting for 59 species.
Effect of Tafamidis on Cardiac Function in Patients With Transthyretin Amyloid Cardiomyopathy
Authors: Shah Sanjiv J. , Fine Nowell , Garcia-Pavia Pablo , Klein Allan L. , Fernandes Fabio , Weissman Neil J. , Maurer Mathew S. , Boman Kurt , Gundapaneni Balarama , Sultan Marla B. , Elliott Perry 
Published: November 2023

ImportanceTafamidis has been shown to improve survival in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) compared with placebo. However, its effect on cardiac function has not been fully characterized.ObjectiveTo examine the effect of tafamidis on cardiac function in patients with ATTR-CM.Design, Setting, and ParticipantsThis was an exploratory, post hoc analysis of the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT), a multicenter, international, double-blind, placebo-controlled phase 3 randomized clinical trial conducted from December 2013 to February 2018. The ATTR-ACT included 48 sites in 13 counties and enrolled patients aged 18 to 90 years with ATTR-CM. Data were analyzed from July 2018 to September 2023.InterventionPatients were randomized to tafamidis meglumine, 80 mg or 20 mg, or placebo for 30 months.Main Outcomes and MeasuresPatients were categorized based on left ventricular (LV) ejection fraction at enrollment as having heart failure with preserved ejection fraction (≥50%), mildly reduced ejection fraction (41% to 49%), or reduced ejection fraction (≤40%). Changes from baseline to month 30 in LV ejection fraction, LV stroke volume, LV global longitudinal strain, and the ratio of early mitral inflow velocity to septal and lateral early diastolic mitral annular velocity (E/e′) were compared in patients receiving tafamidis, 80 mg, vs placebo.ResultsA total of 441 patients were randomized in ATTR-ACT, and 436 patients had available echocardiographic data. Of 436 included patients, 393 (90.1%) were male, and the mean (SD) age was 74 (7) years. A total of 220 (50.5%), 119 (27.3%), and 97 (22.2%) had heart failure with preserved, mildly reduced, and reduced LV ejection fraction, respectively. Over 30 months, there was less pronounced worsening in 4 of the echocardiographic measures in patients receiving tafamidis, 80 mg (n = 176), vs placebo (n = 177) (least squares mean difference: LV stroke volume, 7.02 mL; 95% CI, 2.55-11.49; P = .002; LV global longitudinal strain, −1.02%; 95% CI, −1.73 to −0.31; P = .005; septal E/e′, −3.11; 95% CI, −5.50 to −0.72; P = .01; lateral E/e′, −2.35; 95% CI, −4.01 to −0.69; P = .006).Conclusions and RelevanceCompared with placebo, tafamidis, 80 mg, attenuated the decline of LV systolic and diastolic function over 30 months in patients with ATTR-CM. Approximately half of patients had mildly reduced or reduced LV ejection fraction at enrollment, suggesting that ATTR-CM should be considered as a possible diagnosis in patients with heart failure regardless of underlying LV ejection fraction.Trial RegistrationClinicalTrials.gov Identifier: NCT01994889
The Best Psoriasis Medications Emerge
Authors: Blauvelt Andrew , Noe Megan H. 
Published: November 2023

Clinical QuestionWhat are the most effective systemic medications to treat plaque psoriasis?Bottom LineThe most effective drugs for psoriasis were infliximab, bimekizumab, ixekizumab, and risankizumab, and the clinical effectiveness was similar when these 4 drugs were compared against one another. No statistically significant differences in serious adverse events were identified in any of the drugs compared with placebo. The main limitations of this meta-analysis include the lack of assessment of clinical effectiveness beyond 52 weeks and the lack of safety assessments for nonserious adverse events.
Shared Decision‐Making During Virtual Care Regarding Rheumatologic and Chronic Conditions: Qualitative Study of Benefits, Pitfalls, and Optimization
Authors: Zickuhr Lisa , McCarthy Catherine , Nolan‐Thomas Emma , Westrich‐Robertson Tiffany , Baker Elizabeth A. , Hanson Janice L. 
Published: November 2023

ObjectiveVirtual care (VC) is an accepted modality of care delivery, and shared decision‐making (SDM) benefits patients with rheumatologic and chronic conditions (RCCs). Unfortunately, research suggests reduced quality of SDM during VC. This study explores the benefits and shortcomings of SDM regarding RCCs during VC with suggestions for optimally using VC during SDM.MethodsFollowing Stiggelbout's framework for SDM, we conducted focus groups of patients with RCCs and providers to understand their experiences with SDM during VC, probing for facilitating and challenging factors. We conducted content analysis of the transcripts, defining themes, and inductively reasoned to identify relationships among themes. We summarized the facilitators, barriers, and opportunities for improving SDM during VC that participants proposed.ResultsVirtual SDM shares several similarities with in‐person practice, as both draw upon trusting patient‐provider relationships, following the same general steps, and relying on effective communication. VC presents solutions for known barriers to in‐person SDM, expanding time for making decisions and access to care. Technology and virtual health systems introduce new barriers to SDM, and participants list opportunities for overcoming these concerns.ConclusionVC is a tool that can enhance and even support superior SDM compared with in‐person visits when implemented successfully, a condition requiring the development of nuanced skills to correctly identify when and how to best use VC for SDM as well as technology and health care structures that integrate SDM into VC. Therefore, patients, providers, insurance carriers, and policy makers all contribute to the success of SDM among RCCs during VC.
Medium‐ and High‐Entropy Spinel Ferrite Nanoparticles via Low‐Temperature Synthesis for the Oxygen Evolution Reaction
Authors: Zander Judith , Wölfel Julia Petra , Weiss Morten , Jiang Yiqun , Cheng Ningyan , Zhang Siyuan , Marschall Roland 
Published: November 2023

AbstractHigh‐entropy oxides are a material class that is currently receiving rapidly increasing attention due to the large variety in composition and the adjustable properties. Cooperative effects between different metal cations in the crystal structure in addition to entropic phase stabilization have proven beneficial for electrocatalytic applications. Most synthesis methods, however, require high synthesis temperatures and long times, and additionally only yield selected samples in good phase‐purity. Furthermore, toxic or scarce elements are often present in large amounts. Herein, a non‐aqueous microwave‐assisted solvothermal synthesis is presented as a fast and low‐temperature alternative for the fabrication of a wide range of earth‐abundant ferrites (AFe2O4). Directly crystalline, phase‐pure spinel ferrites of various compositions ranging from one to seven different A‐ions are successfully obtained after only 30 min at 225 °C. A detailed characterization of their properties in relation to their composition is performed, and they are also employed for the alkaline oxygen evolution reaction. A partial replacement of Fe by Co moreover shows the high versatility of the synthesis that also allows for the simultaneous variation of the B‐ion.
Janus Metasurface for Super Radome with Asymmetric Diffusion and Absorption
Authors: Wang Shaojie , Xu He‐Xiu , Wang Mingzhao , Wei Hang , Zhang Fan , Hu Guangwei 
Published: November 2023

AbstractMetasurface radome is crucial to protect the radiating antenna and control electromagnetic waves flexibly. However, current design methods for metasurface radome merely focus on the single propagation direction, with limited degrees of freedom. Here, a super radome is proposed with a directional scattering response based on Janus metasurface that can realize the phase modulation of y‐polarized waves and the amplitude modulation of x‐polarized waves with a judiciously designed structure. Both numerical and experimental results illustrate two cross‐polarized transmission windows with intensity exceeding 0.9 centered at 10 and 12.2 GHz and two out‐of‐band invisibility with considerable backward radar cross‐section reduction over −10 dB within 9.3–15.4 and 7.5–23.8 GHz when the radome is illuminated by y‐ and x‐polarized waves along negative and positive z directions, respectively. Moreover, the radar cross‐section reduction is maintained for off‐normal incidence even up to 45°. This method sets up a directional degree of freedom for advanced radome design and demonstrates its enormous potential in developing next‐generation stealth antennas.
Advances in Functionalized Applications of Graphene‐Based Wearable Sensors in Healthcare
Authors: Akter Mahmuda , Anik Habibur Rahman , Tushar Shariful Islam , Tania Imana Shahrin , Chowdhury Md. Kamrul Hassan , Hasan Shah Md. Maruf , Bristy Bebe Fatema 
Published: November 2023

AbstractGraphene has earned significant attention in the present world due to its light weight and extremely good conductive properties, which are used in different functional materials and smart devices. With skyrocketing demand, wearable sensors are evolving with many essential functionalities and flexibility in use. Moreover, wearable sensors can show some marvelous activities easily when they are incorporated with different nanomaterials and two‐dimensional (2D) materials. Therefore, after the immense effort and diligence of scientists over the years, wearable sensors can successfully exhibit numerous potential applications, such as motion detection, artificial intelligence, prosthetic skin, intelligent robotics, and human‐machine interface and interaction. With the rapid development of flexible, perceptible electrical devices, graphene‐based wearable sensors play an eminent role in healthcare. In this work, a comprehensive overview of recent research on wearable sensors and integrated systems for various sections of healthcare is demonstrated. Along with discussing the basic properties of graphene and the fabrication methods for graphene‐based wearable sensors, this work can help the scientists address them and set a projection for future studies. Wearable graphene‐based sensors have great potential to make healthcare facilities more accessible and enhance the quality of sensing activities, which has enormous implications for the future of healthcare.
A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Authors: Verbruggen Stefaan W. , Nolan Joanne , Duffy Michael P. , Pearce Oliver M.T. , Jacobs Christopher R. , Knight Martin M. 
Published: November 2023

AbstractBone metastases are a common cause of suffering in breast and prostate cancer patients, however, the interaction between bone cells and cancer cells is poorly understood. Using a series of co‐culture, conditioned media, human cancer spheroid, and organ‐on‐a‐chip experiments, this study reveals that osteocytes suppress cancer cell proliferation and increase migration via tumor necrosis factor alpha (TNF‐α) secretion. This action is regulated by osteocyte primary cilia and associated intraflagellar transport protein 88 (IFT88). Furthermore, it shows that cancer cells block this mechanism by secreting transforming growth factor beta (TGF‐β), which disrupts osteocyte cilia and IFT88 gene expression. This bi‐directional crosstalk signaling between osteocytes and cancer cells is common to both breast and prostate cancer. This study also proposes that osteocyte inhibition of cancer cell proliferation decreases as cancer cells increase, producing more TGF‐β. Hence, a positive feedback loop develops accelerating metastatic tumor growth. These findings demonstrate the importance of cancer cell‐osteocyte signaling in regulating breast and prostate bone metastases and support the development of therapies targeting this pathway.
Fast and Selective Luminescent Sensing by Langmuir–Schaeffer Films Based on Controlled Assembly of Perylene Bisimide Modified with A Cyclometalated AuIII Complex
Authors: Zhang Jing , Shi Zhiwei , Liu Ke , Shi Qiyuan , Yi Liang , Wang Junjie , Peng Lingya , Liu Taihong , Ma Miao , Fang Yu 
Published: November 2023

AbstractCondensed films of functional luminophores dominated by the magnitude and dimensionality of the intermolecular interactions play important roles in sensing performance. However, controlling the molecular assembly and regulating photophysical properties remain challenging. In this study, a new luminophore, ortho‐PBI‐Au, was synthesized by anchoring a cyclometalated alkynyl‐gold(III) unit at the ortho‐position of perylene bisimide. An unprecedented T‐type packing model driven by weak Au‐π interaction and Au−H bonds was observed, laying foundation for striking properties of the luminophore. Controlled assembly of ortho‐PBI‐Au at the air‐water interface, realized using the classical Langmuir–Schaeffer technique, afforded the obtained luminescent films with different packing structures. With an optimized film, sensitive, selective, and rapid detection of a hazardous new psychoactive substance, phenylethylamine (PEA), was achieved. The detection limit, response time, and recovery time were <4 ppb, <1 s, and <5 s, respectively, surpassing the performance of the PEA sensors known thus far. The relationship between the characters of films and the sensing performance was systematically examined by grey relational analysis (GRA). The present study suggests that designing novel molecular aggregation with definite adlayer structure is a crucial strategy to enhance the sensing performance, which could be favorable for the film‐based fluorescent sensors.
Enzyme‐Polymer‐Conjugate‐Based Pickering Emulsions for Cell‐Free Expression and Cascade Biotransformation
Authors: Lu Haofan , Ouyang Jingping , Liu Wan‐Qiu , Wu Changzhu , Li Jian 
Published: November 2023

AbstractIn this study, we addressed the limitations of conventional enzyme‐polymer‐conjugate‐based Pickering emulsions for interfacial biocatalysis, which traditionally suffer from nonspecific and uncontrollable conjugation positions that can impede catalytic performance. By introducing a non‐canonical amino acid (ncAA) at a specific site on target enzymes, we enabled precise polymer‐enzyme conjugation. These engineered conjugates then acted as biocatalytically active emulsifiers to stabilize Pickering emulsions, while encapsulating a cell‐free protein synthesis (CFPS) system in the aqueous phase for targeted enzyme expression. The resulting cascade reaction system leveraged enzymes expressed in the aqueous phase and on the emulsion interface for optimized chemical biosynthesis. The use of the cell‐free system eliminated the need for intact whole cells or purified enzymes, representing a significant advancement in biocatalysis. Remarkably, the integration of Pickering emulsion, precise enzyme‐polymer conjugation, and CFPS resulted in a fivefold enhancement in catalytic performance as compared to traditional single‐phase reactions. Therefore, our approach harnesses the combined strengths of advanced biochemical engineering techniques, offering an efficient and practical solution for the synthesis of value‐added chemicals in various biocatalysis and biotransformation applications.
Reductive Cross‐Coupling of a Vinyl Thianthrenium Salt and Secondary Alkyl Iodides
Authors: Lansbergen Beatrice , Tewari Srija , Tomczyk Ireneusz , Seemann Maik , Buchholz Henning Louis , Rippegarten Mike , Cieminski Daniel Chamier , Juliá Fabio , Ritter Tobias 
Published: November 2023

AbstractWe report the first reductive vinylation of alkyl iodides. The reaction uses a vinyl thianthrenium salt, a palladium catalyst, and an alkyl zinc intermediate formed in situ to trap the LnPdII(vinyl) complex formed after oxidative addition before it undergoes undesired homocoupling to form butadiene.
Antibacterial, antifungal, and anticancer screening of some nano mono Co(II), Zn(II), Ru(III), and Ag(I) binuclear metal complexes of new hydrazone ligand
Authors: Hassan Safaa S. , Rizk Nashwa M. H. , Khidr Manal A. , Aly Samar A. 
Published: November 2023

A new series of Co(II), Zn(II), Ru(III), and Ag(I) complexes with the ligand (Z)‐N′‐(1‐(thiophen‐2‐yl)ethylidene)‐2‐(p‐tolylamino)acetohydrazide (H2L) has been prepared. FT‐IR, 1H‐NMR, electronic spectra, powder X‐ray, and thermal behavior were applied to elucidate the structural composition of new compounds. The electronic spectra proved that the Co(II), Zn(II), and Ru(III) complexes possess tetrahedral geometry, except the Ag(I) complex is a binuclear complex. The mass spectrum of the Zn(II) and Ag(I) chelates and the molecular ion peak observed at m/z values equivalent to the calculated molecular weight confirmed the proposed structure. Also, the SEM scanning electron microscope technique explored the spherical shape of all chelates, and the nanoscale was confirmed through TEM; the transmission electron microscope tool that provided the 7.0 nm was achieved in the case of Zn(II) chelate. Geometry optimization for all synthesized compounds was estimated by density functional theory (DFT) method using the Gaussian09 program. Biological screening as an antimicrobial and antitumor was studied. The Ru(III) complex revealed the greatest antibacterial efficiency, followed by the Co(II) complex. Co(II) complex revealed a greater affinity against fungi such as Candida albicans and Aspergillus niger. All chelate‐induced antitumor effects against the MCF‐7 cell line, especially Ag(I) complex (IC50 = 62.36 μg/mL), exhibited the greatest efficiency. The activity sequence follows the order doxorubicin (standard drugs) > Ag(I) > Zn(II) > ligand < Ru(III) > Co(III) chelates. The molecular docking was performed and validated to support the biological results.
Solid‐state curved focal plane arrays realized with simple approaches for compact and high‐performance optical systems
Authors: Nikzad Shouleh , Jones Todd J. , Hoenk Michael E. , von Allmen Paul 
Published: November 2023

AbstractWe present an overview of our work on design, development, and demonstration of simple and effective approaches to fabricating solid‐state curved focal plane arrays (CFPAs) that have spawned a novel class of detector arrays. CFPAs can dramatically alter the capability and size of image systems, with an especially high impact in scientific and space applications in terms of science‐instrument size, mass, simplicity, optical performance, and cost. The key to the simplicity of our approaches to curved focal plane arrays, implemented in thick, high‐purity silicon or thinned membrane low‐resistivity substrate detectors is that the curvature of the surface is independent of the VLSI fabrication process of imaging arrays. We present the principles of two approaches, results of fabrication of curved arrays, and results of analysis for limits of curving silicon arrays. New concepts and techniques were also developed as spin offs of this program for extreme curvature FPAs and infrared CPFAs.
Do people desire optimism from others during a novel global crisis?
Authors: Miller Jane E. , Strueder Jeremy D. , Park Inkyung , Windschitl Paul D. 
Published: November 2023

AbstractDuring a global crisis, does the desire for good news also mean an endorsement of an optimistic bias? Five pre‐registered studies, conducted at the start of the COVID pandemic, examined people's lay prescriptions for thinking about uncertainty—specifically whether they thought forecasters should be optimistic, realistic, or pessimistic in how they estimated key likelihoods. Participants gave prescriptions for forecasters with different roles (e.g., self, family member, and public official) and for several key outcomes (e.g., contracting COVID and vaccine development). Overall, prescribed optimism was not the norm. In fact, for negative outcomes that were of high concern, participants generally wanted others to have a pessimistic bias in how they estimated likelihoods. For positive outcomes, people favored more accurate estimation. These patterns held regardless of the assumed forecaster's role. A common justification for advocating for a pessimistic bias in forecasts was to increase others' engagement in protective or preventative behaviors.