bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing Anti-Vaping Posts for Effective Communication on Instagram Using Multimodal Deep Learning
Authors: Xie Zidian , Deng Shijian , Liu Pinxin , Lou Xubin , Xu Chenliang , Li Dongmei 
Published: February 2024

Abstract

Introduction
Instagram is a popular social networking platform for sharing photos with a large proportion of youth and young adult users. We aim to identify key features in anti-vaping Instagram image posts associated with high social media user engagement by artificial intelligence.

Aims and Methods
We collected 8972 anti-vaping Instagram image posts and hand-coded 2200 Instagram images to identify nine image features such as warning signs and person-shown vaping. We utilized a deep-learning model, the OpenAI: contrastive language-image pre-training with ViT-B/32 as the backbone and a 5-fold cross-validation model evaluation, to extract similar features from the Instagram image and further trained logistic regression models for multilabel classification. Latent Dirichlet Allocation model and Valence Aware Dictionary and sEntiment Reasoner were used to extract the topics and sentiment from the captions. Negative binomial regression models were applied to identify features associated with the likes and comments count of posts.

Results
Several features identified in anti-vaping Instagram image posts were significantly associated with high social media user engagement (likes or comments), such as educational warnings and warning signs. Instagram posts with captions about health risks associated with vaping received significantly more likes or comments than those about help quitting smoking or vaping. Compared to the model based on 2200 hand-coded Instagram image posts, more significant features have been identified from 8972 AI-labeled Instagram image posts.

Conclusion
Features identified from anti-vaping Instagram image posts will provide a potentially effective way to communicate with the public about the health effects of e-cigarette use.

Implications
Considering the increasing popularity of social media and the current vaping epidemic, especially among youth and young adults, it becomes necessary to understand e-cigarette-related content on social media. Although pro-vaping messages dominate social media, anti-vaping messages are limited and often have low user engagement. Using advanced deep-learning and statistical models, we identified several features in anti-vaping Instagram image posts significantly associated with high user engagement. Our findings provide a potential approach to effectively communicate with the public about the health risks of vaping to protect public health.
Examining Demand and Substitutability of Usual Brand Little Cigars/Cigarillos and Cigarettes in Young Adults Who Dual Use
Authors: Mead-Morse Erin L , Cassidy Rachel N , Kpormegbey Daniel E , Moore Timothy , Oncken Cheryl , Tidey Jennifer W , Delnevo Cristine D , Litt Mark 
Published: February 2024

Abstract

Introduction
Cigarette and little cigar/cigarillo (LCC) dual use is popular among young people and poses a substantial health risk. What remains unclear is the abuse liability of LCCs vs. cigarettes, LCCs’ substitutability for cigarettes, and the influence of flavors on the abuse liability and substitutability of LCCs.

Methods
Sixty-five young adults (18–34 years) who dual use completed hypothetical purchase tasks to measure consumption of usual brand cigarettes and LCCs in 24 hours at increasing prices (demand), and LCC consumption at increasing cigarette prices (substitution). Three demand indices were calculated from raw data: breakpoint (price after which consumption reaches 0), Omax (maximum daily expenditure), and Pmax (price at maximum expenditure). Two indices were estimated using nonlinear mixed-effects modeling: intensity (consumption when free) and price-sensitivity (rate of decline in consumption as price increases). Substitution, and associations of flavored use with demand and substitution, were estimated using linear mixed models.

Results
Results indicated similar abuse liability for LCCs and cigarettes. Intensity was greater for cigarettes, but price-sensitivity was similar. Flavored LCC use was associated with lower price-sensitivity and greater intensity than unflavored. LCCs were significant substitutes for cigarettes, but the effect was small. Flavored use was not associated with substitution.

Conclusions
Among young adults who dual use, LCCs and cigarettes had similar abuse liability, and those who used flavored had higher demand for their LCCs. A flavored cigar ban, as well as targeted prevention and cessation services for those who smoke flavored LCCs, may be important for reducing dual use in young adults.

Implications
Cigarette and LCC dual use remains high among young adults. Using hypothetical purchase tasks with young adults who dual use, LCCs had abuse liability similar to cigarettes, but were only modest substitutes for cigarettes. Participants who used flavored LCCs reported greater abuse liability than those who used unflavored, but not greater substitution for cigarettes. Prevention and cessation services are needed to target LCCs in young people, particularly those smoking flavored products. A flavored cigar ban may help to reduce their demand.
Histoplasmosis Beyond Human Immunodeficiency Virus (HIV): Clinical Characteristics and Outcomes in a Non-HIV Population
Authors: Tello-Mercado Andrea C , Martínez-Guerra Bernardo A , Román-Montes Carla M , Seoane-Hernandez Lisset , Rangel-Cordero Andrea , Martínez-Gamboa Rosa A , Sifuentes-Osornio José , Ponce-de-León Alfredo , González Lara María F , Niembro-Ortega María D 
Published: February 2024

Abstract
Histoplasmosis is an endemic and invasive mycosis caused by Histoplasma capsulatum. We conducted a retrospective study comparing immunosuppressed patients without human immunodeficiency virus (HIV) with a historical cohort of people with HIV and histoplasmosis. We included 199 patients with proven or probable histoplasmosis, of which 25.1% were people without HIV. Diabetes mellitus, chronic kidney disease, hematologic neoplasms, rheumatologic diseases, and transplantations were more frequent among people without HIV (P &lt; .01). Forty-four percent of immunocompromised patients without HIV died within the first 6-week period following their diagnosis. A high suspicion index for histoplasmosis should be kept in immunosuppressed patients.
Prevalence of Chronic Pulmonary Aspergillosis in Two (2) Tuberculosis Treatment Clinics in Lagos, Nigeria: A Prospective Longitudinal Study
Authors: Davies Adeyinka A , Adekoya Abiola O , Balogun Oluwaseyi J , Osaigbovo Iriagbonse I , Nwosu Augustina , Gbaja-biamila Titilola , Osinupebi Olubunmi , Gangneux Jean-Pierre , Oladele Rita O 
Published: February 2024

Abstract

Background
Chronic pulmonary aspergillosis (CPA) is an underrecognized but common complication of pulmonary tuberculosis. In Nigeria, a tuberculosis-endemic country, there is currently no provision to monitor the development of CPA in patients treated for tuberculosis. This study determined the prevalence and incidence of CPA in Lagos, Nigeria.

Methods
A prospective longitudinal study of patients with previously managed tuberculosis was conducted between June 2021 and May 2022. The study cohorts were assessed at 3-month intervals, and the following were collected: sociodemographic data, chest radiographic findings, sputum samples for fungal culture, and venous blood samples for Aspergillus immunoglobulin G estimation. CPA cases were determined using the case definition for resource-constrained countries. Descriptive and inferential statistics were used, and significance was set at a probability of 5% (P &lt; .05).

Results
Of the 141 patients recruited, 79 (56.0%) were in the retreatment and 62 (44.0%) in the posttreatment tuberculosis group. The median age (interquartile range) was 40 (30–52) years, with a male-to-female ratio of 1.1:1. Ninety-seven patients (69%) had a GeneXpert test done, of whom 63 (64.9%) were GeneXpert negative. Cough was the most common symptom, with 15 (11%) patients having hemoptysis. The rate of CPA increased steadily as the study progressed: 44 (31.2%) at commencement, 45 (34.9%) at 3 months, 49 (42.6%) at 6 months, and 51 (54.3%) at 9 months. Thus, the overall prevalence of CPA was 49.7%, and the incidence was 6.1%.

Conclusions
CPA is common in Nigeria and its true burden may still be underestimated. Increased awareness of CPA as a posttuberculosis lung disease is advocated. Evaluation for CPA should be incorporated in patients’ work-up for tuberculosis.
Septic Arthritis of the Spinal Facet Joint: Review of 117 Cases
Authors: Ross John J , Ard Kevin L 
Published: February 2024

Abstract

Background
Septic arthritis of the spinal facet joints is increasingly recognized in the era of magnetic resonance imaging, but its epidemiology, clinical features, management, and prognosis are ill-defined.

Methods
We review 101 previously published cases and report 16 cases occurring at our institutions between 2006 and 2018.

Results
Most patients presented with fever (60%) and back or neck pain (86%). Radiation into the hip, buttock, or limb was present in 34%. The lumbosacral vertebral segments were involved in 78% of cases. Most cases (64%) were due to Staphylococcus aureus. Bacteremia was present in 66% and paraspinal muscle abscesses in 54%. While epidural abscesses were present in 56%, neurologic complications were seen in only 9%, likely because most abscesses arose below the conus medullaris. Neurologic complications were more common with cervical or thoracic involvement than lumbosacral (32% vs 2%, P &lt; .0001). Extraspinal infection, such as endocarditis, was identified in only 22% of cases. An overall 98% of patients survived, with only 5% having neurologic sequelae.

Conclusions
Septic arthritis of the facet joint is a distinct clinical syndrome typically involving the lumbar spine and is frequently associated with bacteremia, posterior epidural abscesses, and paraspinal pyomyositis. Neurologic outcomes are usually good with medical management alone.
‘Ye Shall Do No Injustice in Judgment’—Are Religious Courts to Blame for the Agunah Problem?
Authors: Wolfson KC Lord , Gelley William 
Published: February 2024

Abstract
Orthodox Judaism requires women to receive a religious divorce (Get) from their husbands in order to remarry. The ‘Agunah problem’ refers to the phenomenon whereby husbands deny a Get for financial reasons or pure malice, placing women in a state of limbo where they cannot remarry under Jewish law. According to Daniel Greenberg, newly appointed Parliamentary Standards Commissioner and the author of a recent monograph on the topic, the problem is largely the fault of the divorce procedures followed by religious courts, which may also be in violation of criminal and human rights law. This article contends with Greenberg’s claims, concluding that most of them are based on flawed assumptions of fact or misunderstandings of English or Jewish law. Get refusal is attributable to Get refusers, not the religious courts who enjoy a mere supervisory role in the Jewish divorce process. However, the article does recommend that religious courts providing divorce services improve their levels of transparency to prevent further misunderstandings about the way they operate.
Overlapping between squamous cell carcinoma and mucocutaneous leishmaniasis in a diabetic patient
Authors: Khaddam Hala , Kheder Kheder , Sabouni Rami , Al Mahmoud Younes , Nabhan Rasha 
Published: February 2024

Abstract
Mucocutaneous leishmaniasis (MCL) is a leishmania infection; that usually affects the oral and nasal mucosa. The coexistence of leishmania and malignancy is rarely reported and mainly in immunocompromised patients. We report a case of an overlapping between leishmania and squamous cell carcinoma (SCC) in a 60-year-old immunocompetent Syrian female. The patient presented with a one-year crusty nodule on the lower lip. Since she lives in an endemic region, leishmaniasis was suggested, and confirmed with a Giemsa-stained smear. After 20 days of meglumine antimoniate treatment, the patient revealed no signs of recovery, thus, the treatment was prolonged with the addition of sodium stibogluconate injections. Later, she presented with increased symptoms. A biopsy was performed due to SCC suspicion, and it was verified. The patient underwent complete surgical removal of the lesion. After a one-year follow-up, no recurrence was observed. We illustrated the importance of considering SCC in cases of refractory leishmaniasis.
Congenital absence of right coronary artery: a rare coronary anomaly: case report
Authors: Barakoti Murari Prasad , Shafiu Mohamed , Tiwari Kaushal Kishore , Pant Sadip 
Published: February 2024

Abstract
Single coronary artery is a rare congenital anomaly in which a single coronary artery arises from the aortic root that supplies the entire heart. It has variable clinical presentations ranging from a completely benign course to sudden cardiac death. Identifying and categorizing to high-risk type based on clinical presentation and anatomical features can present adverse cardiac events and provides better prognosis.
Management of vesicoenteric fistulas arising from perforated Meckel’s diverticulum: a report of a case and review of the literature
Authors: Diamantidis Dimitrios , Papatheodorou Nikolaos , Kostoglou Panagiotis , Tsakaldimis Georgios , Botaitis Sotirios 
Published: February 2024

Abstract
Vesicoenteric fistulas are rare, with an incidence of 0.1%–0.2% in the general population, and Meckel’s diverticulum is a rare cause, accounting for less than 5% of cases with challenging diagnosis due to atypical symptoms at the admission. This article presents a case of a vesicoenteric fistula formation between Meckel’s diverticulum perforated by a foreign body and urinary bladder in a 38-years-old Caucasian male admitted to emergency department due to colicky abdominal pain located in the lower abdomen. An extensive review of the literature was conducted referring all the cases of vesicoenteric fistula incorporating Meckel’s diverticulum to elucidate the clinical characteristics, explore the diagnostic yield, and to summarize the therapeutic approach.
Spider angioma at the injection site of the meningitis vaccine
Authors: Alabdullah Hadi , Almousa Maher , Alabdullah Muhammad Nour , Al-shawaf Ahmad Zahi , Douri Thaer 
Published: February 2024

Abstract
Spider angioma is a cutaneous nevus caused by a vascular abnormality, characterized by a central red area with radiating reddish, web-like extensions. It is typically associated with liver cirrhosis, hyperestrogenism, and alcohol consumption. In this case report, we present a unique instance of a patient who developed spider angioma at the injection site of the meningitis vaccine as a long-term adverse effect. The lesion was treated with electrocautery and diminished within one week of treatment. This case highlights the potential for spider angioma to develop as a long-term adverse effect of the meningitis vaccine, a possibility that has not been previously reported. Further research is required to understand the underlying mechanisms and identify potential risk factors for this rare adverse effect.
Dermoscopic and reflectance confocal microscopy findings in palisaded encapsulated neuroma (PEN): report of two histologically confirmed cases
Authors: Konisky Hailey , Huho Hubert , Suvarnakar Aashka , Krishna Sharma , Huho Albert 
Published: February 2024

Abstract
These medical case reports discuss the reflectance confocal microscopy (RCM) features of palisaded encapsulated neuromas (PEN), a relatively uncommon benign neural tumor that predominantly manifests in middle-aged females, most notably on the facial cheek. These reports feature two middle-aged females who both presented with concern for progressively enlarging cheek papules. Dermoscopy revealed the presence of symmetrical, dome-shaped papules with arborizing blood vessels that were not in sharp focus. RCM images revealed a honeycomb pattern, replete with follicular openings and slight papillary dermal fibrosis. Horizontally oriented blood vessels and vellus hair follicles, as well as prominent vellus hair bulbs were noted. The findings were initially perplexing and collectively raised the possibility of a skin adnexal neoplasm. However, subsequent biopsy confirmed a diagnosis of PEN in both cases. In retrospect, the neoplastic cells were beyond the imaging depths of RCM but the observed changes, including alterations in hair follicles on confocal microscopy, were likely due to pressure from the underlying tumor. Consideration of these features aids in diagnosing this unique yet benign neoplasm.
Comparing Drug Shortages Experienced by Institutions With National Metrics
Authors: Pytlowany Austin , Leja Noah , Kent Stanley 
Published: February 2024

Abstract
Drug shortages have steadily increased, in both volume and management complexity, for decades. In turn, this trend has resulted in significant challenges for healthcare staff and patients. Each drug shortage has its own set of variables that determine supply distribution, mitigation strategy, healthcare system strain, and patient impact. The catalyst for the aforementioned chain reaction is a drug shortage’s root cause - which is often unknown. The degree of transparency of this root cause can be correlated with a health system’s ability to effectively manage a drug shortage.
Efficacy and Safety of Trifluridine/Tipiracil-Containing Combinations in Colorectal Cancer and Other Advanced Solid Tumors: A Systematic Review
Authors: Shitara Kohei , Falcone Alfred , Fakih Marwan G , George Ben , Sundar Raghav , Ranjan Sandip , Van Cutsem Eric 
Published: February 2024

Abstract
We performed a systematic literature review to identify and summarize data from studies reporting clinical efficacy and safety outcomes for trifluridine/tipiracil (FTD/TPI) combined with other antineoplastic agents in advanced cancers, including metastatic colorectal cancer (mCRC). We conducted a systematic search on May 29, 2021, for studies reporting one or more efficacy or safety outcome with FTD/TPI-containing combinations. Our search yielded 1378 publications, with 38 records meeting selection criteria: 35 studies of FTD/TPI-containing combinations in mCRC (31 studies second line or later) and 3 studies in other tumor types. FTD/TPI plus bevacizumab was extensively studied, including 19 studies in chemorefractory mCRC. Median overall survival ranged 8.6-14.4 months and median progression-free survival 3.7-6.8 months with FTD/TPI plus bevacizumab in refractory mCRC. Based on one randomized and several retrospective studies, FTD/TPI plus bevacizumab was associated with improved outcomes compared with FTD/TPI monotherapy. FTD/TPI combinations with chemotherapy or other targeted agents were reported in small early-phase studies; preliminary data indicated higher antitumor activity for certain combinations. Overall, no safety concerns existed with FTD/TPI combinations; most common grade ≥ 3 adverse event was neutropenia, ranging 5%-100% across all studies. In studies comparing FTD/TPI combinations with monotherapy, grade ≥ 3 neutropenia appeared more frequently with combinations (29%-67%) vs. monotherapy (5%-41%). Discontinuation rates due to adverse events ranged 0%-11% for FTD/TPI plus bevacizumab and 0%-17% with other combinations. This systematic review supports feasibility and safety of FTD/TPI plus bevacizumab in refractory mCRC. Data on non-bevacizumab FTD/TPI combinations remain preliminary and need further validation.
Finite element modelling of complex 3D image data with quantification and analysis
Authors: Chakkour Tarik 
Published: February 2024

Abstract
The purpose of this study was to examine how to model aggregated material microstructure and its meshing volumic generation that is provided by any data from 3D tomographic image data. The accurate reconstruction of 3D geometry structures from tomographic images is a powerful method in various application areas of materials science. The resulting mesh can be voxelized or conforming based on volumetric tetrahedral meshing. We investigate this creation depending on improving multiple materials marching cubes algorithm (M3C) with smoothing and remeshing algorithms. Then, a strategy for generating good-quality meshing and its robustness is presented, and this is performed with numerical tests. The novelty of this study is to generate a conforming mesh from complicated topology structures, particularly, when the interfaces of bi-materials are connected. This leads to a reduction in the node count in the generated mesh. The influence of some parameters involved in this algorithm is explored during different levels of meshing. In this work, the numerical homogenization approach from various spherical inclusions in the two-phase system using the algorithm M3C is considered to estimate the effective elastic properties. We created the framework with all the associated information, such as inputs in the format .inp files, to make it possible to run it over the Abaqus solver. Then, the Abaqus model based on the finite element method (FEM) was executed in this case for various material microstructures such as polycrystalline, composite, and fiber. We show the main workflow for providing desired results by visualizing the FEM analysis. We also demonstrate the capabilities of meshing methodology in the solver for these material models. The validation of the local mechanical environment from FEM with loading scenarios is achieved to predict displacements and deformations. Mechanical compression tests are performed to investigate the compressive behavior. Finally, stress-strain curves provided a comparison between simulations and experimental data for materials, and a good agreement is obtained.
Double-blinded, randomized clinical trial of Gegen Qinlian decoction pinpointsFaecalibacteriumas key gut bacteria in alleviating hyperglycemia
Authors: Gao Zezheng , Zhang Wenhui , He Lisha , Wang Han , Li Yufei , Jiang Xiaotian , D I Sha , Wang Xinmiao , Zhang Xuan , Han Lin , Liu Yanwen , Gu Chengjuan , Wu Mengyi , He Xinhui , Cheng Lei , Wang Jun , Tong Xiaolin , Zhao Linhua 
Published: February 2024

AbstractBackgroundAccumulating evidence suggests that metabolic disorders, including type 2 diabetes mellitus (T2DM), can be treated with traditional Chinese medicine formulas, such as the Gegen Qinlian decoction (GQD). This study elucidates the mechanisms by which gut microbes mediate the anti-diabetic effects of GQD.MethodsWe conducted a double-blind randomized clinical trial involving 120 untreated participants with T2DM. During the 12-week intervention, anthropometric measurements and diabetic traits were recorded every 4 weeks. Fecal microbiota and serum metabolites were measured before and after the intervention using 16S rDNA sequencing, liquid chromatography-mass spectrometry, and Bio-Plex panels.ResultsAnti-diabetic effects were observed in the GQD group in the human trial. Specifically, glycated hemoglobin, fasting plasma glucose, and two-hour postprandial blood glucose levels were significantly lower in the GQD group than in the placebo group. Additionally, Faecalibacterium was significantly enriched in the GQD group, and the short-chain fatty acid levels were higher and the serum inflammation-associated marker levels were lower in the GQD group compared to the placebo group. Moreover, Faecalibacterium abundance negatively correlated with the levels of serum hemoglobin, fasting plasma glucose, and pro-inflammatory cytokines. Finally, the diabetes-alleviating effect of Faecalibacterium was confirmed by oral administration of Faecalibacterium prausnitzii (DSMZ 17677) in T2DM mouse model.ConclusionsGQD improved type 2 diabetes primarily by modulating the abundance of Faecalibacterium in the gut microbiota, alleviating metabolic disorders and the inflammatory state.Trial registrationRegistry No. ChiCTR-IOR-15006626.