bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of zolbetuximab for first-line treatment of advanced Claudin 18. 2-positive gastric or gastro-esophageal junction adenocarcinoma: a systematic review and meta-analysis of randomized controlled trials
Authors: Liang Zhanpeng , Liu Liwen , Li Wenxia , Lai Huiqin , Li Luzhen , Wu Jiaming , Zhang Huatang , Fang Cantu 
Published: October 2023

ObjectiveZolbetuximab is a “first-in-class” chimeric lgG1 monoclonal antibody targeting Claudin18.2 (CLDN 18.2). In recent years, several important trials have been published showing that zolbetuximab is associated with improved prognosis in patients with advanced gastric or gastro-esophageal junction (G/GEJ) adenocarcinoma. This promises great change to the current treatment landscape. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of zolbetuximab for first-line treatment of advanced CLDN 18. 2-positive G/GEJ adenocarcinoma.MethodsThe following databases were searched for relevant studies: PubMed, EMBASE, and Cochrane library (updated 10 June 2023). All randomized trials comparing zolbetuximab plus chemotherapy versus first-line chemotherapy alone for first-line treatment of advanced CLDN 18. 2-positive G/GEJ adenocarcinoma were eligible for inclusion. Data were analyzed using Review Manager 5.4.1 (Cochrane collaboration software). Primary outcomes and measures included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and adverse events (AEs).ResultsThis systematic review and meta-analysis included three randomized controlled studies involving 1,402 patients (699 receiving zolbetuximab plus chemotherapy and 703 receiving chemotherapy alone). Compared with chemotherapy alone, zolbetuximab plus chemotherapy significantly improved OS (HR = 0.73; 95% CI: 0.68–0.84) and PFS (HR = 0.64; 95% CI: 0.50–0.82), but did not result in a higher ORR (RR = 0.92; 95% CI: 0.82–1.03). Further analysis of CLDN 18.2 expression showed a more significant benefit for OS (HR = 0.69; 95% CI: 0.55–0.87; p = 0.002) and PFS (HR = 0.61; 95% CI: 0.44–0.84; p = 0.003) from zolbetuximab in patients with high expression, while there was significant benefit in patients with lower expression. In terms of AEs, zolbetuximab plus chemotherapy was associated with higher risk of grade 3 and higher AEs, but increased risk of nausea and vomiting were more common.ConclusionThis systematic review and meta-analysis revealed that the effect of zolbetuximab plus chemotherapy was superior to that of chemotherapy alone for first-line treatment of advanced CLDN 18.2-positive G/GEJ adenocarcinoma. Thus, zolbetuximab plus chemotherapy represents a new first-line treatment for these patients. Zolbetuximab plus chemotherapy was associated with higher risk of grade 3 and higher AEs, but was generally manageable.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier (CRD42023437126).
Evaluating the use of a customized digital navigation program to optimize bowel preparation in pediatric colonsocopy
Authors: Dankner Lauren , Quiros Jose Antonio , Volpert Diana , Atreja Ashish 
Published: October 2023

IntroductionAdequate bowel preparation is essential for optimal colonoscopy diagnosis and/or intervention. However, suboptimal bowel preparation occurs in as many as 1 in 3 pediatric colonoscopies, leading to missed diagnoses, procedural complications, wasted resources, and increased costs. We aimed to evaluate the effect of an automated Pediatric Colonoscopy Digital Navigation Program (PC-DNP) on the quality of colonoscopy preparation among pediatric patients.MethodsThe PC-DNP sent patients timely weight-based bowel preparation instructions, video and text-based educational modules, logistical information, and appointment reminders prior to their scheduled diagnostic and/or therapeutic colonoscopies. Physician reported bowel preparation quality among patients/caregivers who were prescribed the PC-DNP were compared to bowel preparation quality of a historical sample of patients/caregivers who received standard care instructions.ResultsWe found that the PC-DNP group had significantly higher bowel preparation quality than the standard care group.ConclusionsThese results demonstrated that automated DNPs may be easily implemented into the pediatric gastroenterologists' practice and may help streamline and improve bowel preparation in pediatric patients.
Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study
Authors: Pan Mingming , Wang Guihua , Zhou Li , Xu Yan , Yao Li , Wu Chaoqing , Mei Changlin , Zhao Zhanzheng , Sun Dong , Guan Tianjun , Chen Qinkai , Shi Ming , Xu Hui , Zeng Weifang , Li Fangqiong , Yan Rui , Liu Bi-Cheng 
Published: October 2023

Background: HSK21542, a novel selective peripherally-restricted κ-opioid receptor agonist has been proven to be a safe and effective analgesic and antipruritic drug in both in vitro and in vivo studies. We aimed to evaluate its safety, pharmacokinetics and efficacy in hemodialysis patients over a 1-week treatment period, and to establish the optimal dosage for a further 12-week stage 2 trial.Methods: In this multiple ascending dose study, hemodialysis patients were randomly assigned to receive HSK21542 (0.05–0.80 μg/kg), or a placebo three times within 2.5 h at the end of each dialysis session for 1 week. Safety evaluations included reports of treatment-emergent adverse events (TEAEs); pharmacokinetics and efficacy outcomes were also assessed.Results: Among the 44 screened patients, 41 were enrolled and completed the trial. The overall incidence of TEAEs was higher in the HSK21542 group compared to the placebo group, with an incidence of 75.0%, 50.0%, 75.0%, and 88.9% in the range of 0.05–0.80 μg/kg. All TEAEs were grade 1 or 2 in severity. HSK21542 exhibited linear pharmacokinetics characteristics within the dose range 0.05–0.80 μg/kg, without drug accumulation after multiple-doses. Compared to the placebo, a significant decrease of the weekly mean Worst Itching Intensity Numerical Rating Scale was found in the HSK21542-0.30 μg/kg group (p = 0.046), but without significant improvement in the Skindex-16 score.Conclusion: HSK21542 was well tolerated in the dose range 0.05–0.80 μg/kg in hemodialysis patients. HSK21542-0.3 μg/kg exhibited promising efficacy in patients with moderate to severe pruritus and warrants a further Stage 2 trial.Clinical Trial Registration:https://clinicaltrials.gov/, identifier NCT04470154.
Effects of physical exercise on non-suicidal self-injury in adolescents: the chain mediating role of perceived social support and self-concept
Authors: Yu Haoran , Mu Qinglei , Li Ke 
Published: October 2023

ObjectiveTo study the effect of physical exercise on non-suicidal self-injury in adolescents and to verify the chain mediating role of perceived social support and self-concept. Methods: A survey study was conducted on 1,426 adolescents in Chengdu, Sichuan Province. A chain mediation model was used to verify whether perceived social support and self-concept played a mediating role.ResultsPhysical exercise was significantly negatively associated with non-suicidal self-injury in adolescents (β = −0.53, p &lt; 0.01) and significantly positively associated with perceived social support and self-concept (β = 0.52, 0.54, p &lt; 0.01), and perceived social support and self-concept were significantly negatively associated with non-suicidal self-injury (β = −0.59, p &lt; 0.01; β = −0.64, p &lt; 0.01), and perceived social support was able to significantly and positively associate self-concept (β = 0.76, p &lt; 0.01).ConclusionPerceived social support and self-concept play a chain mediating role in the effect of physical exercise on non-suicidal self-injury in adolescents, and it is recommended that the development of perceived social support and self-concept be emphasized during adolescents’ development, which has the potential to reduce the incidence of non-suicidal self-injurious behaviors in adolescents.
Hispanic/Latinx ethnic differences in the relationships between behavioral inhibition, anxiety, and substance use in youth from the ABCD cohort
Authors: Correa Kelly A. , Delfel Everett L. , Wallace Alexander L. , III William E. Pelham , Jacobus Joanna 
Published: October 2023

IntroductionElevated levels of behavioral inhibition (BI) may connote risk for both anxiety and substance use disorders. BI has consistently been shown to be associated with increased levels of anxiety, while the association between BI and substance use has been mixed. It is possible that the relationship between BI and substance use varies by individual difference factors. Hispanic/Latinx (H/L) youth in particular may have stronger relationships between BI, anxiety, and substance use.MethodsThe present study therefore evaluated (1) the prospective relationships between BI [assessed via self-reported behavioral inhibition system (BIS) scale scores], anxiety, and substance use in youth (n = 11,876) across baseline, 1-, and 2-year follow-ups of the Adolescent Brain Cognitive Development (ABCD) Study (ages 9–12) and (2) whether these relationships differed by H/L ethnicity while covarying for average behavioral approach system scores, race, sex, age, highest parental income, highest parental education, and past-year substance use (for analyses involving substance use outcomes).ResultsBaseline levels of BIS scores predicted increased anxiety symptoms at both 1- and 2-year follow-ups and did not differ by H/L ethnicity. Baseline levels of BIS scores also prospectively predicted increased likelihood of substance use at 2-year follow-up, but only for H/L youth and not at 1-year follow-up.DiscussionHigh scores on the BIS scale contribute risk to anxiety across ethnicities and may uniquely contribute to risk for substance use in H/L youth.
Linking current dental education to gerontological education to meet the oral health needs of growing aging populations
Authors: Tabrizi Maryam , Lee Wei-Chen 
Published: October 2023

ObjectiveThis study aimed to recognize the gaps in dental education by studying the current level of geriatric oral health training of recent graduated dentists who have been admitted into an Advanced Education in General Dentistry (AEGD) program.MethodsThe AEGD program was developed along with the Age-Friendly 4Ms model to enhance current dental education. We adopted the Rapid Cycle Quality Improvement model to test the effectiveness of the training for AEGD residents from 2019 to 2022. A total of 18 residents participated (6 residents each year). A 5-question survey was administered before and after the rotation and Wilcoxon signed-rank with Fisher Exact tests were conducted to compare pre- and post- rotation results.ResultsAll 18 residents have completed pre- and post-program surveys. They self-reported minimal to no training in preparation to provide care to older adults with multiple chronic conditions. After the rotation, residents’ confidence in treating older adults was significantly increased (p = 0.011). Meanwhile, residents gained knowledge to apply the 4Ms framework (what matters, medication, mentation, and mobility) to their practices (p = 0.015) and provide age-friendly care for older adults.ConclusionThe study identified and addressed the missing link in dental education to gerontological and geriatrics education. More clinical rotations and didactic training to equip residents with competences of providing geriatric oral health are strongly recommended.
Expert goalkeepers’ and coaches’ views on anticipation and cue utilisation facing backcourt throws in handball goalkeeping
Authors: Huesmann Kim , Schorer Jörg , Büsch Dirk , Witt Jelto , Loffing Florian 
Published: October 2023

IntroductionHandball goalkeepers have to act under severe spatio-temporal pressure in both standardised (e.g., 7 m penalty) and non-standardised situations (e.g., backcourt throws) which require them to predict action outcome before ball flight is visible. So far, research on goalkeepers’ cue utilisation for anticipation of an opponent’s action has mainly focused on 7 m throw situations whereas little attention has been paid to the latter, more complex and far more frequently occurring backcourt throw situations.MethodsTo address this gap, we conducted semi-structured interviews with N = 6 expert handball goalkeepers and goalkeeper coaches [all of whom were (former) expert handball goalkeepers] on anticipation and cue utilisation when facing backcourt throws. The interviews were subsequently transcribed, coded and results were inductively as well as deductively categorised by means of a thematic analysis.ResultsResults reveal a variety of kinematic and contextual cues relevant for action anticipation that become available before the game and before or during the throw. Participants reported to use information from the offence (e.g., thrower’s jump; opposing team’s task distribution) and the defence (e.g., defensive players’ strategies, block position) for anticipation in backcourt throw situations. Additionally, we identified several factors that influence cue availability and utilisation.DiscussionOur findings provide a thorough basis to (a) guide future research that yields questions on kinematic and contextual cue integration and in-situ cue usage as well as (b) inform the development of training programs to foster goalkeepers’ anticipatory skill.
Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 Signal
Authors: Xia Kang , Wang Tianyu , Chen Zhongbao , Guo Jiayu , Yu Bo , Chen Qi , Qiu Tao , Zhou Jiangqiao , Zheng Shusen 
Published: October 2023

Background:
Hepatic ischemia-reperfusion injury (HIRI) stands as an unavoidable complication arising from liver surgery, profoundly intertwined with its prognosis. The role of lysine methyltransferase SET domain bifurcated 1 (SETDB1) in HIRI remains elusive, despite its confirmation as a potential therapeutic target for diverse diseases. Here, we investigated the mechanism by which SETDB1 regulated HIRI.
Methods:
RNA sequencing data were used to identify the expression and potential targets of SETDB1 through bioinformatics analysis. To elucidate the impact of SETDB1 on HIRI, both an in vivo model of HIRI in mice and an in vitro model of hepatocyte hypoxia/reoxygenation were established. Biochemical and histological analyses were used to investigate the influence of SETDB1 on liver damage mediated by HIRI. Chromatin immunoprecipitation and coimmunoprecipitation were implemented to explore the in-depth mechanism of SETDB1 regulating HIRI.
Results:
We confirmed that hepatocellular SETDB1 was up-regulated during HIRI and had a close correlation with HIRI-related inflammation and apoptosis. Moreover, inhibition of SETDB1 could mitigate HIRI-induced liver damage, inflammation, and apoptosis. Through our comprehensive mechanistic investigation, we revealed that SETDB1 interacts with apoptosis-signal-regulating kinase 1 (ASK1) and facilitates the methylation of its lysine residues. Inhibition of SETDB1 resulted in reduced phosphorylation of ASK1, leading to a marked suppression of downstream c-Jun N-terminal kinase (JNK)/p38 signaling pathway activation. The therapeutic effect on inflammation and apoptosis achieved through SETDB1 inhibition was nullified by the restoration of JNK/p38 signaling activation through ASK1 overexpression.
Conclusions:
The findings from our study indicate that SETDB1 mediates lysine methylation of ASK1 and modulates the activation of the ASK1–JNK/p38 pathway, thus involved in HIRI-induced inflammation and apoptosis. These results suggest that SETDB1 holds promise as a potential therapeutic target for mitigating HIRI.
TÍNH CHẤT QUANG VÀ PHÁT QUANG CỦA NANO BaMoO4 ĐỒNG PHA TẠP Eu3+, Mn2+ CHẾ TẠO BẰNG PHƯƠNG PHÁP THỦY NHIỆT
Authors: Nhương Chu Mạnh 
Published: October 2023

Nghiên cứu này phân tích các tính chất và khả năng phát quang của vật liệunanoBaMoO4 pha tạp Eu3+, Mn2+(BMEM) được tổng hợp thành công bằng phương pháp thủy nhiệt. Phổ phản xạ khuếch tán (UV-Vis-DRS) cho thấy, các vật liệu BMEM hấp thụ ánh sáng trong vùng tử ngoại với năng lượng vùng cấm từ 4,0833 – 4,1250 eV. Phổ kích thích phát quang và phổ phát quang cho thấy, các nano BMEMcó khả năng phát quang màu đỏ với cường độ lớn tại khoảng bước sóng 616 nm tương ứng với chuyển tiếp 5D0 → 7F2 của ion Eu3+. Sự dập tắt huỳnh quang theo cơ chế tương tác lưỡng cực – lưỡng cực, mạng nền truyền năng lượng hiệu quả đến ion Eu3+ với khoảng cách tới hạn là 10,62 Å, thời gian sống phát quang cao nhất là 1,06432 ms. Với khả năng phát quang ánh sáng đỏ cường độ lớn trong thời gian dài, vật liệu nano BMEMcó tiềm năng ứng dụng trong chế tạo đèn Led ánh sáng trắng, ấm, tiêu hao ít năng lượng.
Igor Stravinsky: In Memoriam
Authors: Баранова-Монигетти Т.Б. 
Published: October 2023

Статья задумана как продолжение опубликованной в декабрьском номере «Музыкальной академии» за 2022 год работы Т. Барановой-Монигетти, посвященной оммажам Стравинского. На этот раз в центре внимания находится другой вид «музыки на случай» ― мемориальные опусы Стравинского, а также сочинения других композиторов, посвященные его памяти. В статье последовательно рассмотрены все мемориальные опусы Стравинского ― их исторические архетипы, жанровые идиомы, семантически значимые приемы, типовые интонации, драматургические, структурные и тембровые решения. В процессе работы привлекались архивные источники из Собрания Стравинского в Фонде Пауля Захера ― эскизы, копии сочинений других авторов, пометки в изданиях из личной библиотеки, материалы из неопубликованной переписки. Впервые предпринята попытка обобщить обширный пласт композиторского творчества конца ХХ ― начала XXI века, посвященного Стравинскому, показать особенности диалога композиторов разных поколений и направлений с его музыкой (использование словесных эпиграфов, буквенной и числовой символики, анаграмм, цитат, стилевых аллюзий, особой нотной графики). В связи с публикацией данной статьи редакция журнала «Музыкальная академия» инициировала создание нескольких новых произведений памяти Стравинского. В развернутых комментариях к этим сочинениям приведены фрагменты из интервью с авторами.
This article was intended as a continuation of the same author’s publication in Muzykal’naya akademiya (no. 4, 2022) about Stravinsky’s musical offerings (hommages). This time, the focus is on another kind of “occasional music,” namely on Stravinsky’s memorial compositions and works by different composers dedicated to his memory. The article consecutively examines Stravinsky’s memorial opuses from “Funeral Song” to “Requiem canticles” in the context of his work (their historical archetypes, genre idioms, semantically significant techniques, typical intonations, dramaturgical, structural and timbre solution). In the course of the study archival materials from Stravinsky’s collection in the Paul Sacher Foundation were used—sketches, handwritten copies of works by other authors, marginal remarks in the editions from his library, and materials from unpublished correspondence. For the first time, an attempt was made to generalize the vast layer of the composers’ work of the late 20th–21st centuries dedicated to Stravinsky’s memory. The author of the article analyzes the dialogue between the composers of the following generations and his music, including the use of verbal epigraphs, alphabetic and numerical symbols, anagrams, quotations, style allusions, and special musical notation. In connection with the publication of this article, the editors of the “Music Academy” initiated the creation of several new works in memory of Stravinsky. The comments on these works include materials from interviews with the authors.
Searching for a Unified Style
Authors: Кривицкая Е.Д. 
Published: October 2023

150-летие со дня рождения Рахманинова стало событием общероссийского масштаба. Впервые юбилей композитора столь широко отмечался на родине, с которой у него непросто складывались отношения. На данном этапе можно констатировать безого­ворочное признание Рахманинова как русского классика, и это стало импульсом к появлению нового научного труда, посвященного стилю композитора. Ученые Московской консерватории поставили перед собой оригинальную задачу — написать коллективную монографию, где стиль Рахманинова рассматривался бы с разных, но не противоречащих друг другу позиций. Заведующая кафедрой истории русской музыки И. А. Скворцова (инициатор создания этого труда) сфокусировалась на вопросе правомерности включения Рахманинова в систему координат эпохи модерна и развернула убедительную систему аргументов. Проректор по научной работе К. В. Зенкин показал стилистические аллюзии и обозначил диалог Рахманинова с многочисленными предшественниками. Сотрудники кафедры истории русской музыки посвятили свои исследования особенностям формообразования и звуковысотной организации в музыке композитора сквозь призму национальной песенной традиции (Т. А. Старостина), индивидуальному стилю на примере его фортепианных концертов (Н. Д. Свиридовская), духовным сочинениям в контексте церковно-певческого канона (Н. В. Гурьева), симфоническим партитурам и их стилевым закономерностям (Д. И. Топилин).
The sesquicentenary of Rachmaninoff’s birth became an event of an all-Russian scale. For the first time, the anniversary of this composer was celebrated so widely in his homeland, with which he had a complicated relationship. At this stage, one can state the absolute recognition of Rachmaninoff as a Russian classic, that became the impetus for the appearance of a new scientific work dedicated to the composer’s style. The scientists of Moscow Conservatory set themselves an original task—to write a collective monograph, where Rachmaninoff’s style would be regarded from different, but not contradictory positions. Head of the Russian Music History Department I. A. Skvortsova (initor of this work) focused on the legitimacy of including Rachmaninoff in the modern era coordinate system and deployed convincing arguments. Vice-Rector for Research K. V. Zenkin set the task of showing stylistic allusions and designating Rachmaninoff’s dialogue with numerous predecessors. Members of the Russian Music History Department of Moscow Conservatory dedicate their research to the features of formation and pitch organization in Rachmaninoff’s music through the prism of the national folk-song tradition (T. A. Starostina), the composer’s style on the example of his piano concertos (N. D. Sviridovskaya), and religious compositions in the context of Orthodox church music singing canon (N. V. Guryeva), symphonic scores and their stylistic similarities (D. I. Topilin).
PENYULUHAN PENTINGNYA TANAMAN LEGUM UNTUK MENINGKATKAN KETERSEDIAAN HARA PADA TANAH YANG TIDAK SUBUR
Authors: Maulida Elly Istiana , Santosa Sartono Joko , Ferdianto Alfa Reza Deva 
Published: October 2023

Kabupaten Sragen memiliki luas wilayah 941,6 km2 yang terdiri dari 20 kecamatan dan dibagi menjadi 208 desa atau kelurahan. Kelurahan Karangpelem merupakan salah satu yang akan dijadikan tempat kegiatan pengabdian kepada masyarakat karena mayoritas masyarakatnya berpencaharian sebagai petani dan peternak yang masih memerlukan penyuluhan tentang menggurangi penggunaan pupuk anorganik. Pengaplikasian pupuk anorganik yang berlebihan mengakibatkan kesuburan tanah rendah sehingga akhir – akhir ini para petani di desa Karangpelem banyak yang mengeluhkan hasil panennya yang rendah. Tujuan dari pengabdian masyarakat ini yaitu memberikan penyuluhan tentang manfaat tanaman legum terutama orok–orok sebagai tanaman penyedia unsur hara sehingga mampu meningkatkan kesuburan tanah dan mengurangi penggunaan pupuk anorganik yang merusak tanah. Penyuluhan dilakukan dengan metode ceramah, tanya jawab dan praktek pengaplikasian tanaman orok–orok sebagai pupuk yang dilakukan pada budidaya tanaman terrarium kemudian dilakukan monitoring. Hasil dari pelaksanaan kegiatan pengabdian masyarakat adalah tanah yang awalnya tidak subur setelah diaplikasikan tanaman orok-orok menjadi subur yang dibuktikan pada budidaya terrarium.

Kata Kunci: Tanaman orok–orok, ketersediaan hara, kesuburan