bluuebunny/crossref_metadata_2025_split huggingface dataset:
1138. A Scoping Review of the Role of the Provider in HPV Vaccination Dyads Research, 2012-2022
Authors: Clare Alyssa F , Agudelo Claudia L Gaviria , Walker Kimberly 
Published: November 2023

Abstract

Background
Despite the influence of provider recommendation on Human papillomavirus (HPV) vaccine uptake, few studies in the last decade have assessed the provider’s role in impacting parent and adolescent decisions regarding this vaccine. Given the increasing role of shared decision-making in health decisions, we sought to identify studies that assessed the role of the provider in affecting HPV vaccine decisions among parent-adolescent dyads.

Methods
Inclusion criteria: English-written, original studies from 2012-2022 with a sample including a parent and at least one of the parent’s own adolescents, and with a focus on parent-adolescent intentions and decisions about HPV vaccination. Initial retrieval resulted in 256 studies screened, with 14 meeting eligibility, and seven meeting all qualifications for inclusion.

Results
Clinicians were found to be influential in a dyad’s shared decision to vaccinate against HPV, especially when providing a rationale for vaccination (1, 4, 6). The dyad’s intention to speak with a provider was positively correlated with the likelihood of getting vaccinated (r=0.37, p&lt; 0.05) (5). Both dyad members had high confidence in their provider’s ability to answer questions regarding HPV vaccination (3). Each dyad member felt that the HPV vaccine was discussed more than other vaccines (1). One study explored the relationship between provider-obtained information and adolescent risk perceptions. Less knowledge regarding the HPV vaccine was independently associated with females’ perception of less need for safe sexual practices (p&lt; 0.10) (6). Lastly, delay in receiving the final vaccine dose was associated with decreased accessibility for immunization appointments (7).

Conclusion
Providers play a significant role in HPV education, as they continue to serve as an important source of information for parents and adolescents. Each dyad member perceives unique benefits and risks to HPV vaccination. When approaching a dyad, providers should attempt to include both the adolescent and the parent in the discussion. Future directions for this research include exploring if addressing dyad members individually improves HPV vaccine uptake.

Disclosures
All Authors: No reported disclosures
1143. Meningococcal Vaccination Coverage Disparities in the United States: An Analysis with 2016-2021 National Immunization Survey-Teen Data
Authors: Herrera-Restrepo Oscar , Kwiatkowska Marta , Ndegwa Nelson , Poston Sara , Ganz Michael 
Published: November 2023

Abstract

Background
The US Advisory Committee on Immunization Practices recommends meningococcal vaccination against serogroups A, C, W, and Y (MenACWY) for 11–12 year-olds (y/o) with a booster at 16; and against serogroup B (MenB) for 16–23 y/o under shared clinical decision making (SCDM). We used a large US survey to assess vaccination coverage across vaccines, geography and race/ethnicity.

Methods
This was a cross-sectional analysis using 2016-2021 National Immunization Survey-Teen survey data on MenACWY (≥1 dose [d]) in 13 y/o, MenACWY (≥2 d) and MenB (≥1 d) in 17 y/o. Data were collected via phone interviews with provider confirmation. We assessed coverage throughout the calendar year for MenACWY (≥1 d) and MenB (≥1 d) after the interview date, and for MenACWY (≥2 d) at the interview date.

Results
MenACWY coverage (≥1 d) in 13 y/o evolved from 82.71% (2016) to 86.42% (2021). MenACWY coverage (≥1 d) in 13-17 y/o changed from 83.36% (2016) to 89.82% (2021). MenB coverage (≥1 d) in 17 y/o changed from 5.63% (2016) to 34.05% (2021).
Geographic coverage was more variable moving from MenACWY (≥1 d) in 13 y/o (74.44% Pacific region 2016 to 91.00% New England region 2021) to MenACWY (≥2 d) in 17 y/o (21.05% East South Central region 2016 to 75.68% Mid-Atlantic region 2021) and MenB (≥1 d) in 17 y/o (2.34% Pacific region 2016 to 45.29% South Atlantic region 2021). MenACWY coverage (≥1 d) in 13 y/o was consistent across race/ethnicity, while 17 y/o Hispanic had lower MenACWY coverage (≥2 d) in 2021 (50.63%). For MenB (≥1 d) in 17 y/o, coverage varied by race/ethnicity; coverage in Hispanic and Non-Hispanic (NH) Black populations increased from 5.55% and 7.55% to 33.58% and 42.33% over 5 years, respectively. In NH White population, coverage yearly increased from 5.29% to 33.88%, while it only progressed from 5.34% to 27.17% in other NH + Multiple race population.

Conclusion
Meningococcal vaccination disparities persist across vaccines, ages, geography, and race/ethnicity (MenB only). Disparities increase with age, and with SCDM- versus routinely- recommended vaccines (MenB vs. MenACWY). Top performing states show that better coverage is possible (∼70% MenB coverage in North Dakota vs. 34% nationally in 2021), pointing at the need to reduce access barriers to vaccination, e.g., via simplified vaccine recommendations/schedules.

Disclosures
Oscar Herrera-Restrepo, PhD, GSK: Stocks/Bonds Sara Poston, PharmD, GSK: Stocks/Bonds
1150. Invasive meningococcal disease vaccination – a targeted literature review of adolescents and parents/caregivers’ preferences
Authors: Begum Shahina , Cabrera Eliazar Sabater , Herrera-Restrepo Oscar , Khera Twinkle , Botha Willings , Batchelder Laurie , Kocaata Zeki 
Published: November 2023

Abstract

Background
Invasive meningococcal disease (IMD) serogroups A, B, C, W, Y are commonly prevented by MenACWY and MenB vaccines. MenABCWY candidate vaccines could potentially provide benefits as less injections, simplified schedules, and increased uptake. However, there is limited insight on factors influencing preferences for IMD vaccines/vaccination (Vax). This targeted literature review synthesized evidence of factors influencing IMD Vax preferences in 16–23-year-old adolescents/young adults (Ado/YA) and parents/caregivers (P/CG) of 16-18 year-old adolescents.

Methods
PubMed and Google Scholar were searched globally to identify publications on IMD Vax attitudes and preferences (Table 1). Studies were restricted to English and published between 2005-2022. Data were extracted and synthesized from full text reviews to list IMD Vax preference attributes.

Results
From the 77 abstracts screened, 19 publications were extracted (Table 2) and 17 relevant for Ado/YA and P/CG. Knowledge of disease severity (20% of Ado/YA articles) and vaccine (29% of P/CG articles) were the most reported factors influencing Vax preference. Severity of disease increased Vax preference for both groups (14%), while low disease awareness limited P/CGs’ willingness to vaccinate children (14% of P/CG articles). Some Ado/YA preferred fewer injections in the immunization series due to reduced injection site discomforts (13%). P/CG preferred less injections due to less time and less physician visits, as it may reduce vaccine preparation/injection/administration and indirect costs associated with parental work loss (7%). However, their concerns over injection-related pain were a Vax barrier (14%). IMD vaccine effectiveness was recognized by Ado/YA (13%). Longer duration of protection was important for P/CG (14%), whilst herd immunity and direct protection was preferred in Ado/YA (13%).

Conclusion
Findings highlight IMD Vax characteristics as key considerations among Ado/YA and P/CG when making Vax decisions. To improve vaccination coverage and protection, the evidence supports preferences for vaccinations offering benefits such as fewer injections. Trade-offs between factors relevant for a IMD combination vaccine need further research.

Disclosures
Shahina Begum, GSK: Employee Eliazar Sabater Cabrera, PhD, GSK: Employee|GSK: Stocks/Bonds Oscar Herrera-Restrepo, PhD, GSK: Stocks/Bonds Twinkle Khera, Mtech, IQVIA: Advisor/Consultant Willings Botha, PhD, IQVIA: Advisor/Consultant Laurie Batchelder, PhD, IQVIA: Advisor/Consultant Zeki Kocaata, PhD, GSK: Stocks/Bonds
Turnover intentions of police officers: Influence of burnout, supervisor support, and job satisfaction
Authors: Nonis Sarath , Hester Kim , McDaniel Karen , Philhours Melodie 
Published: November 2023

Abstract
Public service employees are often those in front-line positions, and face stress due to their boundary spanning job requirements. During the Covid 19 pandemic, additional strain was felt by these front-line workers as they were required to continue close contact with others. For police officers, stress may lead to psychological effects such as burnout, lower levels of job satisfaction, and higher levels of turnover intentions. Additionally, some occupational groups such as policing are at a higher risk of developing mental health problems. This is becoming increasingly important for many cities and their police department budgets, as increasing labor costs for staffing and turnover has become a major concern. This study seeks to better understand how these specific factors influence turnover intentions for police officers in a mid-size suburban US police department, how organizations can help address mental health, and make practical suggestions on how to impact these staffing decisions.
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice
Authors: Huang He-Zhou , Ai Wen-Qing , Wei Na , Zhu Ling-Shuang , Liu Zhi-Qiang , Zhou Chao-Wen , Deng Man-Fei , Zhang Wen-Tao , Zhang Jia-Chen , Yang Chun-Qing , Hu Ya-Zhuo , Han Zhi-Tao , Zhang Hong-Hong , Jia Jian-Jun , Wang Jing , Liu Fang-Fang , Li Ke , Xu Qi , Yuan Mei , Man Hengye , Guo Ziyuan , Lu Youming , Shu Kai , Zhu Ling-Qiang , Liu Dan 
Published: November 2023

AbstractSporadic or late-onset Alzheimer’s disease (LOAD) accounts for more than 95% of Alzheimer’s disease (AD) cases without any family history. Although genome-wide association studies have identified associated risk genes and loci for LOAD, numerous studies suggest that many adverse environmental factors, such as social isolation, are associated with an increased risk of dementia. However, the underlying mechanisms of social isolation in AD progression remain elusive. In the current study, we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD mice. We also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus (DG)-enriched miRNAs, which simultaneously target reticulon 3 (RTN3), an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons (MFBs) by recruiting multiple mitochondrial and vesicle-related proteins. Interestingly, the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation, which, in turn, further elevates RTN3 and forms a vicious cycle. Finally, using an artificial intelligence-assisted molecular docking approach, we determined that senktide, a selective agonist of neurokinin3 receptors (NK3R), could reduce the binding of RTN3 with its partners. Moreover, application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD mice. Taken together, our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.
An international multicentre analysis of current prescribing practices and shared decision-making in psoriatic arthritis
Authors: Watson Lily , Coyle Conor , Whately-Smith Caroline , Brooke Melanie , Kiltz Uta , Lubrano Ennio , Queiro Rubén , Trigos David , Brandt-Juergens Jan , Choy Ernest , D’Angelo Salvatore , Delle Sedie Andrea , Dernis Emmanuelle , Guis Sandrine , Helliwell Philip , Ho Pauline , Hueber Axel J , Joven Beatriz , Koehm Michaela , Montilla Carlos , Packham Jon , Pinto Tasende José Antonio , Ramirez Garcia Felipe Julio , Ruyssen-Witrand Adeline , Scrivo Rossana , Twigg Sarah , Soubrier Martin , Wirth Théo , Gossec Laure , Coates Laura C 
Published: November 2023

Abstract

Objectives
Shared decision-making (SDM) is advocated to improve patient outcomes in PsA. We analysed current prescribing practices and the extent of SDM in PsA across Europe.

Methods
The ASSIST study was a cross-sectional observational study of PsA patients ≥18 years of age attending face-to-face appointments between July 2021 and March 2022. Patient demographics, current treatment and treatment decisions were recorded. SDM was measured by the clinician’s effort to collaborate (CollaboRATE questionnaire) and patient communication confidence (PEPPI-5 tool).

Results
A total of 503 patients were included from 24 centres across the UK, France, Germany, Italy and Spain. Physician- and patient-reported measures of disease activity were highest in the UK. Conventional synthetic DMARDs constituted a higher percentage of current PsA treatment in the UK than continental Europe (66.4% vs 44.9%), which differed from biologic DMARDs (36.4% vs 64.4%). Implementing treatment escalation was most common in the UK. CollaboRATE and PEPPI-5 scores were high across centres. Of 31 patients with low CollaboRATE scores (&lt;4.5), no patients with low PsAID-12 scores (&lt;5) had treatment escalation. However, of 465 patients with CollaboRATE scores ≥4.5, 59 patients with low PsAID-12 scores received treatment escalation.

Conclusions
Higher rates of treatment escalation seen in the UK may be explained by higher disease activity and a younger cohort. High levels of collaboration in face-to-face PsA consultations suggests effective implementation of the SDM approach. Our data indicate that in patients with mild disease activity, only those with higher perceived collaboration underwent treatment escalation. Prospective studies should examine the impact of SDM on PsA patient outcomes.

Trial registration
clinicaltrials.gov, NCT05171270.
Weight loss maintenance following an augmented intervention for early slow weight loss responders: An adaptive trial
Authors: Miller Carla K , Nagaraja Haikady N , Fujita Kentaro , Cheavens Jennifer S , Focht Brian C 
Published: November 2023

Abstract
Early slow weight loss during treatment is associated with less weight loss overall. The impact of an augmented intervention designed for early slow weight loss responders compared with a standard diabetes prevention intervention was evaluated following 12 months of treatment and 6 months of no contact. The impact of standard vs. augmented intervention sequences on weight and glycemia also was determined. Adults were ≥21 years old with overweight or obesity and prediabetes (n = 174). Slow responders were stratified to augmented treatment if they failed to achieve &gt;2.5% weight loss (%WL) at Week 5. Matched within-sex pairs of participants were created based on %WL at Month 5 following the intensive intervention phase, and each person within the pair was randomly assigned to treatment for Months 5–12 during the extended intervention phase. Both 12-month interventions included a ≥7%WL goal. Mean 12-month %WL was 5.29% (95% CI: 4.27%–6.31%; P &lt; .0001) and 18-month %WL was 3.34% (95% CI: 2.01%–4.66%; P &lt; .0001) overall. %WL was greater for the standard (9.55%) than the augmented (4.0%) intervention (P = .0001); no differences occurred in weight regain between early and slow responders (P = .9476). No differences occurred in mean %WL at 12 months between the standard and augmented groups after controlling for %WL at Week 5 and sex (P = .23) nor in the change in glycemia (all P &gt; .05). WL following the first month of treatment predicted 12- and 18-month WL success regardless of intervention sequence; however, even early slow responders achieved significant WL during treatment. Further research is needed to support effective WL maintenance for people with prediabetes.
Tailored Indications for Different Neurotoxins
Authors: Sezgin Billur 
Published: November 2023

Background:
Minimally invasive procedures have become increasingly popular because they require minimal downtime and are effective for achieving a more youthful appearance. All U.S. Food and Drug Administration–approved neurotoxins are indicated for achieving similar effects, even though they are different in regard to structure, manufacturing technique, and storage requirements. It is agreed upon that each neurotoxin is unique and therefore not interchangeable. The aim of the author is to provide an approach for choosing the optimal toxin in different indications regarding the area of treatment, the age and characteristics of the patient, potential risks, and ultimate goals.

Methods:
As the country that the author practices carries onabotulinum (ONA), prabotulinum (PRA), and abobotulinum (ABO) toxin type-A, one of these three toxins was preferred for each category. ABO toxins were preferred in wide areas due to the broader action halo. Typical examples include hyperhidrosis treatment, wide forehead area, and calf slimming. In areas where very precise and targeted treatment is required, PRA and ONA toxins were preferred to limit potential side effects due to wider diffusion. First-time patients were typically treated with PRA toxins for a softer trial periods where as “repeat” patients were successfully treated with ABO toxins.

Results:
No toxin is superior to the other in terms of producing effects. Yet, small differences in their properties can allow the plastic surgeon to cater to each patient’s needs while yielding the most optimal results.

Conclusions:
This study is meant to serve as a guideline for choosing the ideal toxin in different patient settings and indications.
Preventive Cardiovascular Care for Hypercholesterolemia in US Emergency Departments: A National Missed Opportunity
Authors: Ashburn Nicklaus P. , Snavely Anna C. , Rikhi Rishi , Shapiro Michael D. , Chado Michael A. , Stopyra Jason P. , Mahler Simon A. 
Published: November 2023

Background:
Hypercholesterolemia (HCL) affects nearly half of Emergency Department (ED) patients who present with possible acute coronary syndrome (ACS). However, it is unknown whether US ED providers obtain lipid panels, calculate 10-year atherosclerotic cardiovascular disease (ASCVD) risk, and prescribe cholesterol-lowering medications for these patients.

Methods:
We conducted a nationwide cross-sectional ED survey from April 18, 2023, to May 12, 2023. An electronic survey assessing current preventive HCL care practices for patients being evaluated for ACS. A convenience sample was obtained by sharing the survey with ED medical directors, chairs, and senior leaders using emergency medicine professional organization listservs and snowball sampling. Responding EDs were categorized as being associated with an academic medical center (AMC) or not (non-AMC).

Results:
During the 4-week study period, 110 EDs (50 AMC and 60 non-AMC EDs) across 39 states responded. Just 1.8% (2/110) stated that their providers obtain a lipid panel on at least half of patients with possible ACS and only one ED (0.9%) responded that its providers calculate 10-year ASCVD risk and prescribe cholesterol medication for the majority of eligible patients. Most reported never obtaining lipid panels (60.9%, 67/110), calculating 10-year ASCVD risk (55.5%, 61/110), or prescribing cholesterol-lowering medications (52.7%, 58/110).

Conclusions:
The vast majority of US ED providers do not provide preventive cardiovascular care for patients presenting with possible ACS. Most ED providers do not evaluate for HCL, calculate ASCVD risk, or prescribe cholesterol-lowering medications for these patients.
Measuring Emergency Department Staff Perceptions of Causes and Management of Violence
Authors: Ewen Julia , Gaeta Lisa , Fitzgerald Karen A. , Ragione Barbara L. , Feil Deborah A. , Raio Christopher C. , Arrillaga Abenamar , Klein Lauren R. , Eckardt Patricia A. 
Published: November 2023

BACKGROUND:
Half of all reported violent incidents in health care settings occur in the emergency department (ED) placing all staff members at risk. However, research typically does not include all ED work groups or validated measures beyond nurses and physicians.

OBJECTIVE:
The aims of this study were to (a) validate an established instrument measuring perceptions of causes of violence and attitudes toward managing violence within an inclusive workforce sample; and (b) explore variation in perceptions, attitudes, and incidence of violence and safety to inform a violence prevention program.

METHODS:
This is an investigator-initiated single-site cross-sectional survey design assessing the psychometric properties of the Management of Aggression and Violence Attitude Scale (MAVAS) within a convenience sample (n = 134). Construct validity was assessed using exploratory factor analysis and reliability was evaluated by the Cronbach's α estimation. Descriptive, correlational, and inferential estimates explored differences in perceptions, attitudes, and incidence of violence and safety.

RESULTS:
Exploratory factor analysis indicated validity of the MAVAS with a seven-factor model. Its internal consistency was satisfactory overall (Cronbach's α= 0.87) and across all subscales (Cronbach's α values = 0.52–0.80). Significant variation in incidence of physical assault, perceptions of safety, and causes of violence was found between work groups.

CONCLUSIONS:
The MAVAS is a valid and reliable tool to measure ED staff members' perceptions of causes of violence and attitudes toward managing violence. In addition, it can inform training according to differences in work group learner needs.
A Fast-Track Respiratory Protocol for High Cervical Spine Injury: A Case Report
Authors: Pan Caixue , Chen Yao , Zhou Yongfang 
Published: November 2023

BACKGROUND:
Cervical spinal cord injury can greatly affect pulmonary function, resulting in complications, including respiratory failure with prolonged mechanical ventilation, ultimately leading to increased mortality and high health care costs. Weaning from mechanical ventilation is particularly challenging in patients with complete high spinal cord injury.

CASE PRESENTATION:
We present the case of a 42-year-old man who suffered a complete cervical 5–6 spinal cord injury following a rollover motor vehicle crash and subsequently developed postoperative pneumonia and severe hypoxemic respiratory failure. He received a novel approach to fast-track respiratory care, including early and aggressive secretion clearance management, moderate pressure level of airway pressure release ventilation, timely transition to spontaneous mode, early tracheostomy and humane care, and high-flow oxygenation via tracheotomy after weaning off the ventilator. As a result, the patient experienced significant improvement in pulmonary function and was successfully liberated from the ventilator within a 2-week period.

CONCLUSION:
This case highlights the potential effectiveness of fast-track respiratory care in promoting lung function restoration and expediting liberation from mechanical ventilation in patients with severe hypoxemic respiratory failure following a complete cervical spinal cord injury. However, further research is warranted to validate these findings and expand our understanding in this area.