bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrarotspektroskopische Untersuchungen an Koordinationsverbindungen des Aluminiumwasserstoffs
Authors: Dautel Rolf , Zeil Werner 
Published: October 2023

AbstractDie Ultrarotspektren einer größeren Anzahl von Koordinationsverbindungen des Aluminiumwasserstoffs wurden aufgenommen. Auf Grund der Spektren läßt sich eine Klassifizierung der Koordinationsverbindungen vornehmen. Dabei wird das H− ‐Ion als Donator betrachtet. Über eine polymere Verbindung von AlH3 mit Dioxan wird berichtet.
Hypoxemia of the lower limbs during robot‐assisted radical prostatectomy in Trendelenburg position
Authors: Haeuser Lorine , Münker Mara , Frey Ulrich H. , Klaaßen Marina , Noldus Joachim , Palisaar Rein‐Jüri 
Published: October 2023

AbstractObjectivesThe objective of this study is to assess frequency and risk factors for intraoperative hypoxemia of the lower limbs during robot‐assisted radical prostatectomy (RARP). Trendelenburg position during RARP may contribute to hypoxemia and compartment syndrome (CS) of the lower limbs as a major but rare complication.Patients and methodsThis prospective study included patients undergoing RARP for prostate cancer. Preoperative calculation of the ankle‐brachial‐index (ABI) was performed. Peripheral oxygen saturation (SpO2) at the toes was routinely measured. Occurrence of SpO2 levels of <90% was defined as hypoxemic events and treated immediately. Blood pressure, intraabdominal pressure, SpO2 of the upper limb and surgery time were monitored in case of hypoxemia. A multivariable logistic regression model was performed with age, BMI, nicotine abuse, MAP, comorbidities as covariates and hypoxemia of the lower limbs as the outcome.ResultsA total of 207 patients were included. Among these, 126 patients had ABI measurements with 10.6% having an abnormal ABI value. One, two or at least three events of lower limb hypoxemia occurred intraoperatively in 19.7%, 14.8% and 16.9%, respectively. In 20 events, surgical instruments were affecting vascular perfusion by compression. None of the covariates were statistically significant associated with lower limb hypoxemia. No patient developed a compartment syndrome.ConclusionDecrease in oxygen saturation of the lower extremities was observed frequently during RARP, without revealing any risk factors for its occurrence. Routine oximetry leads to an early detection of hypoxemia of the lower extremities, giving the anaesthesiologist and surgeon the opportunity to make adequate adjustments (increasing blood pressure and ending iliac vessel compression).
Cationic Rhodium Diphosphane Complexes as Efficient Catalysts for the Semi‐Hydrogenation of Dehydroisophytol
Authors: Jannsen Nora , Pribbenow Cornelia , Selle Carmen , Jackstell Ralf , Drexler Hans‐Joachim , Müller Marc‐André , Medlock Jonathan A. , Bonrath Werner , Heller Detlef 
Published: October 2023

AbstractThe selective reduction of terminal alkynes to alkenes was investigated using common cationic diphosphane rhodium complexes of the type [Rh(PP)(diolefin)]X (PP=diphosphane, X=anion). The effectiveness of the catalyst was demonstrated in the semi‐hydrogenation of dehydroisophytol (DIP), an industrial produced intermediate of vitamin E. The present study highlights the high activity and good selectivity of this simple catalytic system. However, deactivation increases at higher DIP concentrations. Several strategies to circumvent the deactivation are presented.
Molecular Accessibility and Diffusion of Resorufin in Zeolite Crystals
Authors: Erik Maris J. J. , Parker Luke A. , Stanciakova Katarina , Nikolopoulos Nikolaos , Berendsen Koen M. H. , van Blaaderen Alfons , Meirer Florian , Rabouw Freddy T. , Weckhuysen Bert M. 
Published: October 2023

AbstractWe have used confocal laser scanning microscopy on the small, fluorescent resorufin dye molecule to visualize molecular accessibility and diffusion in the hierarchical, anisotropic pore structure of large (~10 μm‐sized) zeolite‐β crystals. The resorufin dye is widely used in life and materials science, but only in its deprotonated form because the protonated molecule is barely fluorescent in aqueous solution. In this work, we show that protonated resorufin is in fact strongly fluorescent when confined within zeolite micropores, thus enabling fluorescence microimaging experiments. We find that J‐aggregation guest–guest interactions lead to a decrease in the measured fluorescence intensity that can be prevented by using non‐fluorescent spacer molecules. We characterized the pore space by introducing resorufin from the outside solution and following its diffusion into zeolite‐β crystals. The eventual homogeneous distribution of resorufin molecules throughout the zeolite indicates a fully accessible pore network. This enables the quantification of the diffusion coefficient in the straight pores of zeolite‐β without the need for complex analysis, and we found a value of 3×10−15 m2 s−1. Furthermore, we saw that diffusion through the straight pores of zeolite‐β is impeded when crossing the boundaries between zeolite subunits.
Recent Advances in the Synthesis and Polymerization of New CO2‐Based Cyclic†
Authors: Lanzi Matteo , Kleij Arjan W. 
Published: October 2023

Comprehensive SummaryCarbon dioxide can be converted into functional heterocycles known as cyclic carbonates, whose recent reactivity has been expanded towards the formation of tailor‐made engineering polymers. This minireview gives an overview of the most topical developments in this area with a special focus on the synthetic methods employed to prepare these CO2 based synthons. In addition, their application potential in the area of polymer science using a variety of polymerization techniques is discussed that have in common the ring‐opening of the carbonate monomers. Future perspectives are provided that provide impetus for the scientific communities aligning research to the use of sustainable processes for polymers from recyclable carbon sources such as CO2.
The cellular microenvironment regulates CX3CR1 expression on CD8+ T cells and the maintenance of CX3CR1+ CD8+ T cells
Authors: Pokharel Jyoti , Shryki Iman , Zwijnenburg Anthonie J. , Sandu Ioana , Krumm Laura , Bekiari Christina , Avramov Victor , Heinbäck Rebecka , Lysell Josefin , Eidsmo Liv , Harris Helena E. , Gerlach Carmen 
Published: October 2023

AbstractExpression levels of the chemokine receptor CX3CR1 serve as high‐resolution marker delineating functionally distinct antigen‐experienced T‐cell states. The factors that influence CX3CR1 expression in T cells are, however, incompletely understood. Here, we show that in vitro priming of naïve CD8+ T cells failed to robustly induce CX3CR1, which highlights the shortcomings of in vitro priming settings in recapitulating in vivo T‐cell differentiation. Nevertheless, in vivo generated memory CD8+ T cells maintained CX3CR1 expression during culture. This allowed us to investigate whether T‐cell receptor ligation, cell death, and CX3CL1 binding influence CX3CR1 expression. T‐cell receptor stimulation led to downregulation of CX3CR1. Without stimulation, CX3CR1+ CD8+ T cells had a selective survival disadvantage, which was enhanced by factors released from necrotic but not apoptotic cells. Exposure to CX3CL1 did not rescue their survival and resulted in a dose‐dependent loss of CX3CR1 surface expression. At physiological concentrations of CX3CL1, CX3CR1 surface expression was only minimally reduced, which did not hamper the interpretability of T‐cell differentiation states delineated by CX3CR1. Our data further support the broad utility of CX3CR1 surface levels as T‐cell differentiation marker and identify factors that influence CX3CR1 expression and the maintenance of CX3CR1 expressing CD8+ T cells.
Lipidomic analysis and classification of Iberian dry‐cured hams with low field NMR
Authors: Pajuelo Abraham , Ramiro José Luis , Fernández‐Marcos María Luisa , Sánchez Soledad , Pérez‐Palacios Trinidad , Antequera Teresa , Marcos Carlos F. 
Published: October 2023

AbstractIberian ham is a high‐quality food that is traditionally produced from black pigs that are native to the Iberian Peninsula. The taste and texture of Iberian ham are largely determined by its lipid content and composition. In this work, low field 1H‐NMR spectroscopy was used for the first time to analyze the lipid profile of Iberian hams as a determinant of quality. The quantification of fatty acids (FAs) is readily obtained from the integration of the spectral peaks. The FA profile is highly influenced by the diet of the pigs, with monounsaturated FAs being more prominent in hams from acorn‐fed pigs. The NMR data was analyzed using a sparse partial least squares multivariate data analysis multivariate model, which allowed for the categorization of Iberian hams according to the pig's feeding regime. The main variables on which this classification is based are FA unsaturation and triacyl glyceride hydrolysis. On the other hand, there are no significant differences in the phospholipid content of the different categories of Iberian hams as determined by colorimetric and inductively coupled plasma optical emission spectroscopy methods.Benchtop 1H‐NMR spectroscopy has thus revealed as an operationally simple and powerful tool for the lipid analysis and classification of Iberian hams according to the diet of pigs.
CAD/CAM‐assisted ablative surgery and intraoperative brachytherapy for pediatric skull‐base sarcomas
Authors: Lopez Joseph , Subramanian Tejas , Stambuk Hilda , Schreyer Mark , Woods Robbie , Scholfield Daniel , Wong Richard , Cohen Marc A. , Shah Jatin , Ganly Ian 
Published: October 2023

AbstractBackgroundHead and neck (H&N) sarcomas in children can poise numerous challenges to the surgical oncologist and require multidisciplinary input and meticulous surgical planning. The application of computer‐assisted design/computer‐assisted manufacturing (CAD/CAM) has been extensively examined in H&N reconstruction in adults, but its utility in ablative oncologic surgery in children warrants further examination. We present preliminary results utilizing CAD/CAM techniques to assist in planning tumor resections and the application of intra‐operative radiation in children with skull‐base sarcomas.MethodsA retrospective cohort review of all pediatric patients who presented to a tertiary care cancer center for surgical resection of a skull‐base malignancy was performed between 1980 and 2021. All children under 18 years of age with diagnosis of a skull‐base sarcoma as confirmed with imaging and pathology were analyzed.ResultsA total of 21 children were identified but only four children with skull‐base sarcomas had diagnostic imaging available in whom computer‐assisted volumetric analyses were generated. In these cases, CAD/CAM was used to plan surgical approaches and intraoperative radiotherapy, significantly aiding in treatment for these complicated pediatric cases.ConclusionCAD/CAM planning for oncologic resection has huge potential. Here we have shown its utility in pre‐operative surgical planning and for administration of intraoperative radiation therapy. Future studies are needed to examine its value in facilitating intraoperative surgical management and patient outcomes, as well as cost effectiveness.
Early detection of pharyngocutaneous fistulae after total laryngectomy by cytokine in drainage: A pilot study (DEFILAC)
Authors: Saroul Nicolas , Loukine Margaux , Durand Marc , Pereira Bruno , Rozand Isabelle , Becaud Justine , Martinez Quentin , Mom Thierry , Gilain Laurent , Evrard Bertrand , Puechmaille Mathilde , Bonnet Benjamin 
Published: October 2023

AbstractBackgroundThe determination of cytokines in the postoperative drainage (POD) fluid could be a method for early detection of the development of a pharyngocutaneous fistula (PCF).Materials and methodsWe conducted a prospective two‐center study involving 28 patients. PODs were collected on Day 1 (D1) and Day 2 (D2) postoperatively for determination of a cytokine panel and cytobacteriological examination.ResultsEleven (39%) patients presented with PCF on average 13 ± 5.5 days after surgery. Patients with PCF had higher IL‐10 (121 vs. 40.3, p = 0.04, effect size (ES) = 0.98 [0.16, 1.79]) and TNFα level (21.2 vs. 2.2, p = 0.02, ES = 0.83 [0.03, 1.63]) on D2. An IL‐10 threshold of 72 pg/mL on D2 was diagnostic of the occurrence of PCF with a sensibility of 70%, specificity of 88%.ConclusionThe determination of cytokines in POD fluid on D2 is a reliable tool for predicting the development of a PCF after total laryngectomy.
TERT promoter mutation positive oral cavity carcinomas, a clinically and genetically distinct subgroup of head and neck squamous cell carcinomas
Authors: Saito Yuki , Kage Hidenori , Kobayashi Kenya , Yoshida Masafumi , Fukuoka Osamu , Yamamura Koji , Mukai Toshiyuki , Oda Katsutoshi , Yamasoba Tatsuya 
Published: October 2023

AbstractBackgroundsThe importance of TERT promoter (pTERT) mutation of oral cavity squamous cell carcinoma (OCSCC) with clinical features and genetic alterations are not well recognized.MethodsWe retrospectively analyzed genetic data from multiple databases, including 260 cases from the C‐CAT database, 407 cases from the MSK‐MetTropism database, and 40 OCSCC datasets from in‐house clinical samples.ResultsFrom C‐CAT database, TP53 (66%), CDKN2A (51%), and pTERT (29%) were the most frequent mutations observed. pTERT mutations were more prevalent in OCSCC (63%), younger individuals, and women (46%), with lower rates of alcohol abuse and smoking and co‐mutated with TP53, HRAS, and CASP8. MSK‐MetTroposim data validated with the enrichment of pTERT mutations in OCSCC, among women and Asian individuals. In‐house datasets OCSCC with pTERT mutation (50%) characterized by fewer recurrent neck metastases.ConclusionThe study suggests that OCSCC with pTERT mutation represents a distinct subgroup with unique clinical and genetic characteristics.
Aquatic macrophyte growth season in Central and Northern European Union and the implications for aquatic macrophyte risk assessments for herbicides
Authors: Crosland Helena , Brooks Amy , Hackett Michael , Witt Johannes , Preuss Thomas G. 
Published: October 2023

Abstract
Under current European Union regulation, the risks to aquatic organisms must be assessed for uses of plant protection products (PPPs) that may result in exposure to the environment. For herbicidal PPPs, aquatic macrophytes are often the most sensitive taxa. For some herbicidal modes of action, macrophytes may be affected only while they are actively growing. For the risk assessment, it is therefore useful to know whether application timings would result in surface water exposure during periods when aquatic macrophytes are actively growing (therefore potentially resulting in effects). Toxicity endpoints, which are based on studies with active growth, may be overconservative in cases where exposure of PPPs will not co-occur with active macrophyte growth. A comprehensive literature search was performed, using systematic and manual approaches, with the aim of identifying the main active growth period for macrophytes in natural freshwater bodies in climates relevant to the Central and Northern zones of the European Union. The results of the searches were screened initially to identify all potentially relevant references, for which a full evaluation was then performed. Reliability was assessed using the principles of the Klimisch scoring system. As part of the full evaluation, growth periods were identified for each macrophyte species studied. Finally, the extracted growth periods were considered together to determine an overall active growth period for aquatic macrophytes representative of the Central and Northern EU zones. Based on this literature review, the active growth period identified for most aquatic macrophyte species representative of the Central and Northern EU zones is April to September. Relating to the regulatory implication of these results, it may be possible to conclude a low risk for aquatic macrophytes if the predicted surface water exposure period for certain PPPs is demonstrated to be outside the periods of active growth. Integr Environ Assess Manag 2024;20:1125–1139. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Key Points
A literature search was performed with the aim of identifying aquatic macrophyte growth periods relevant to the Central zone (CZ) and the Northern zone (NZ) of the European Union. Following a data mining exercise using peer-reviewed journals, 25 publications were reviewed and considered relevant to the aims of this report, from which 43 collated growth periods were extracted. The extracted data were concluded to support a growth period for aquatic macrophytes in CZ and NZ EU beginning in April and ending in September. This has implications for the authorization of plant protection products with herbicidal modes of action, which act on macrophytes when they are actively growing.
Two‐year, single‐centre, real‐life experience with permethrin 5% and benzyl benzoate 25% in 228 children with scabies: A retrospective report
Authors: Restano Lucia , Brusasco Marco , Cappadona Claudio , Monzani Nicola A. , Cavalli Riccardo 
Published: October 2023

AbstractBackgroundScabies are a significant health issue for institutions and represent a health burden in children. Topical treatments such as permethrin 5% are usually effective but lately, a loss of efficacy has been observed.ObjectivesTo describe demographic data, topical treatment schemes (permethrin 5%; benzyl benzoate 25%) and outcomes in children with scabies over the past 2 years.MethodsWe retrospectively evaluated records of children aged 0 to 14 years with scabies treated in our outpatient clinic from 1 January 2021 to 31 December 2022.ResultsTwo hundred and thirty‐one records were evaluated. Permethrin 5% (P5%) was used as first‐line treatment in 103 children with a success rate of 81.5%; benzyl benzoate 25% (BB25%) was successful in 94.3% of 123 patients. Three patients were lost for follow up and two received other therapies. Mean days of application using P5% increased from 4.1 to 6.8 in 2 years, whereas BB25% showed an opposite trend, from 10 days to 4.7. With the same days of application, the success rate with BB25% was higher (repeated cycle of 2 treatment days, 7 days apart [2 + 2]: 93.3% for BB25% vs. 82.9% for P5%; 3 + 3‐day regime: 91.9% for BB25% vs. 83% for P5%). Twenty‐three out of 26 patients who still had active scabies after the first cycle cleared with a second treatment cycle, with the same topical treatment, or with a different agent. Mild to moderate skin irritation was the only side effect observed (18.4%), more frequently associated with BB25% (81%).ConclusionsDuring the observational period, the use of permethrin decreased while regimen duration increased, probably due to a perceived lack of efficacy. Conversely the use of benzyl benzoate both as first‐line treatment and after permethrin failure increased, despite being more correlated to local inflammation. Both 2 + 2 and 3 + 3 regimes for P5% and BB25% may be considered as suitable first‐line treatment of scabies in children.
Evaluating uncertainty to improve a common monitoring method and guide management decisions for diamond‐backed terrapins
Authors: Bradke Danielle R. , Crawford Brian A. , Kaylor Michelle , Maerz John C. 
Published: October 2023

AbstractDesigning monitoring with adequate certainty to evaluate management actions can be challenging, especially for elusive species in relatively inaccessible habitats. The diamond‐backed terrapin (Malaclemys terrapin) is considered a high priority species for management in all states within its range. Among key threats to terrapin populations is bycatch mortality in crab pots, prompting states throughout the species' range to consider crabbing regulations and creating a need for a monitoring approach able to evaluate the success of any new crabbing regulations to benefit terrapins. Because terrapins occupy extensive and often difficult to access estuarine habitat, it is hard to collect sufficient data to estimate population responses accurately and precisely for management. To assist state managers with decisions regarding monitoring bycatch reduction regulations, we modeled 12 years of terrapin capture‐recapture data. We used estimates from those models to simulate capture‐recapture data pre‐ and post‐implementation of bycatch reduction that resulted in a 0.20 absolute increase in mean apparent survival probability. Results indicated weak reliability of a monitoring approach using only manual seining of tidal creeks to detect a real management effect, with a positive management effect detected at the 95% certainty level only 34% of the time. When we considered 85% and 75% certainty thresholds, we detected a positive effect on survival among 61% and 75% of simulations, respectively. Low within‐year recapture probability and the effect of tide amplitude on terrapin availability indicate there is low feasibility of improving monitoring precision at a single site, requiring monitoring of more sites to improve confidence in the detection of the management effect. The number of sites monitored depends on the acceptable level of certainty. We recommend that researchers and management entities that use seining assess the level of certainty they require to evaluate management actions and increase the number of sites sampled to meet that level of certainty. Additionally, the use of multiple monitoring methods and integrated models should be explored to reduce uncertainty and to allow for easier monitoring of more populations over broader spatial scales.
Hydrogels for the Treatment of Myocardial Infarction: Design and Therapeutic Strategies
Authors: Liang Jiaheng , Lv Ronghao , Li Maorui , Chai Jin , Wang Shuo , Yan Wenjun , Zheng Zijian , Li Peng 
Published: October 2023

AbstractCardiovascular diseases (CVDs) have become the leading global burden of diseases in recent years and are the primary cause of human mortality and loss of healthy life expectancy. Myocardial infarction (MI) is the top cause of CVDs‐related deaths, and its incidence is increasing worldwide every year. Recently, hydrogels have garnered great interest from researchers as a promising therapeutic option for cardiac tissue repair after MI. This is due to their excellent properties, including biocompatibility, mechanical properties, injectable properties, anti‐inflammatory properties, antioxidant properties, angiogenic properties, and conductive properties. This review discusses the advantages of hydrogels as a novel treatment for cardiac tissue repair after MI. The design strategies of various hydrogels in MI treatment are then summarized, and the latest research progress in the field is classified. Finally, the future perspectives of this booming field are also discussed at the end of this review.