bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming
Authors: Luri‐Rey Carlos , Gomis Gabriel , Glez‐Vaz Javier , Manzanal Almudena , Martinez Riaño Ana , Rodriguez Ruiz Maria E. , Teijeira Alvaro , Melero Ignacio 
Published: October 2023

SummaryAntigen cross‐priming of CD8+ T cells is a critical process necessary for the effective expansion and activation of CD8+ T cells endowed with the ability to recognize and destroy tumor cells. The cross‐presentation of tumor antigens to cross‐prime CD8+ T cells is mainly mediated, if not only, by a subset of professional antigen‐presenting cells termed type‐1 conventional dendritic cells (cDC1). The demise of malignant cells can be immunogenic if it occurs in the context of premortem stress. These ways of dying are termed immunogenic cell death (ICD) and are associated with biochemical features favoring cDC1 for the efficient cross‐priming of tumor antigens. Immunosurveillance and the success of immunotherapies heavily rely on the ability of cytotoxic immune cells, primarily CD8+ T cells and NK cells, to detect and eliminate tumor cells through mechanisms collectively known as cytotoxicity. Recent studies have revealed the significance of NK‐ and CTL‐mediated cytotoxicity as a prominent form of immunogenic cell death, resulting in mechanisms that promote and sustain antigen‐specific immune responses. This review focuses on the mechanisms underlying the cross‐presentation of antigens released during tumor cell killing by cytotoxic immune cells, with an emphasis on the role of cDC1 cells. Indeed, cDC1s are instrumental in the effectiveness of most immunotherapies, underscoring the significance of tumor antigen cross‐priming in contexts of immunogenic cell death. The notion of the potent immunogenicity of cell death resulting from NK or cytotoxic T lymphocyte (CTL)‐mediated cytotoxicity has far‐reaching implications for cancer immunotherapy.
Exploring digital banking adoption in developing Asian economies: Systematic literature review and bibliometric analysis
Authors: Tuli Ela 
Published: October 2023

AbstractConsumers’ comfort and familiarity with digital interactions are helping drive the rise of digital banking. Banks are responding to customers’ demands by introducing cutting‐edge digital services designed to improve customers’ quality of life and cut costs. To better understand the obstacles preventing the widespread adoption of digital banking in developing Asian economies, we conducted a systematic literature review and bibliometric analysis for this study. The data is extracted from the Scopus database, which initially contains 4211 articles, from which 152 articles were selected using PRISMA 2020 criteria for bibliometric analysis using VOSviewer and Biblioshiny software, and 85 papers were subjected to full‐text review. The review, limited to the Scopus database, uncovered essential themes, theories and methodologies used in prior research. We discuss constraints, difficulties and research gaps, illuminating critical regions of the field. Our findings offer helpful information for developing strategies to encourage the use of digital banking. The unexplored areas of crowdfunding, Robo‐advisors, payment apps, neo banks, P2P lending apps and investing apps were highlighted as future research directions.
Progress, employment and profit: The construction of the mafioso social capital and the Sack of Palermo
Authors: Scalia Vincenzo 
Published: October 2023

AbstractThe Sack of Palermo that took place from the 1950s to the 1980s dramatically changed the Sicilian capital's economic and social landscape. Vast tracts of what was agricultural land, including the Conca d'Oro citrus plain, were destroyed as the city was engulfed by concrete. The Mafia played a principal role in this process. This paper will show how Cosa Nostra consolidated its business through social and local connections by granting employment to the members of lower classes such as craftsmen and construction workers and thus gaining consent. The building process of a mafioso social capital, bound together by the ideology of progress, will be analysed through a qualitative analysis.
Hybridizing a matheuristic with ALNS for the optimal collection and delivery of medical specimens
Authors: Ferone Daniele , Festa Paola , Fugaro Serena , Pastore Tommaso 
Published: October 2023

AbstractThe past few years of the COVID‐19 pandemic outbreak have shown that optimal management of medical specimens is a key aspect of healthcare logistics, both for addressing the delivery of perishable items such as vaccines, and for ensuring the timely analysis of swabs and samples. Accordingly, recent optimization literature described the problem of optimal collection and delivery of medical specimens, modeled as a multitrip vehicle routing problem with time windows and a completion time objective function. Aiming to achieve good‐quality solutions in short computational times, this work describes a hybrid approach, combining a matheuristic construction phase with an adaptive large neighborhood search (ALNS). Our matheuristic relies on a clustering algorithm to yield subsets of the medical specimens that are optimally served by single vehicles of the fleet. The solutions of the matheuristic phase serve as starting points for the ALNS intensification phase. Extensive experimentation on both new and established benchmark problem instances shows that our hybrid method is able to match the optimality of the state of the art on small instances and outperforms the existing exact method by one order of magnitude on larger problems.
The incidence of intraoperatively acquired pressure injuries in the park‐bench position was reduced by applying soft silicone multilayer foam dressings
Authors: Yoshimura Mine , Kohno Michihiro , Okamoto Yukako , Tsuchiya Sakura , Ogawa Kyoko , Fukuma Akane , Kurihara Chie , Miyama Mari , Matsumura Hajime 
Published: October 2023

AbstractThe Park‐Bench Position (PBP) is associated with a high incidence rate of intraoperatively acquired pressure injuries (IAPIs). Preventive measures must be established to prevent the development of IAPIs. We investigated the risk factors for PBP by applying a soft silicone multilayered foam dressing (SMD) under core temperature management to prevent IAPIs. We conducted a prospective, single‐centre, open‐label observational study of patients undergoing elective neurosurgery operations using PBP in a university hospital in Japan. The incidence rate of IAPIs in this study was compared with that in our two previous studies, in which a film dressing was applied and core temperature management was not performed. IAPIs developed in 90 patients (6.7%); in the lateral thoracic region in five patients and the iliac crest region in one patient. The operative time (every 1 h: p = 0.0001, OR: odds ratio 3.62, 95% CI: confidence interval 1.73–11.42) was significantly associated with the incidence of IAPIs. In our two previous studies, the incidence rate of IAPIs was 11.0% and 24.1%, respectively, when film dressing was used. SMD may weaken the involvement of risk factors in IAPIs.
The correlation between transcutaneous oxygen pressure (TcPO2) and forward‐looking infrared (FLIR) thermography in the evaluation of lower extremity perfusion according to angiosome
Authors: Nam Ha Jong , Wee Syeo Young , Kim Se Young , Jeong Hyun Gyo , Lee Da Woon , Byeon Je‐Yeon , Park Sang‐Ho , Choi Hwan Jun 
Published: October 2023

AbstractThe increased peripheral arterial disease (PAD) incidence associated with aging and increased incidence of cardiovascular conditions underscores the significance of assessing lower limb perfusion. This study aims to report on the correlation and utility of two novel non‐invasive instruments: transcutaneous oxygen pressure (TcPO2) and forward‐looking infrared (FLIR) thermography. A total of 68 patients diagnosed with diabetic foot ulcer and PAD who underwent vascular studies at a single institution between March 2022 and March 2023 were included. Cases with revascularization indications were treated by a cardiologist. Following the procedure, ambient TcPO2 and FLIR thermography were recorded on postoperative days 1, 7, 14, 21 and 28. In impaired limbs, TcPO2 was 12.3 ± 2 mmHg and FLIR thermography was 28.7 ± 0.9°C. TcPO2 (p = 0.002), FLIR thermography (p = 0.015) and ankle–brachial index (p = 0.047) values significantly reduced with greater vascular obstruction severity. Revascularization (n = 39) significantly improved TcPO2 (12.5 ± 1.7 to 19.1 ± 2.2 mmHg, p = 0.011) and FLIR (28.8 ± 1.8 to 32.6 ± 1.6°C; p = 0.018), especially in severe impaired angiosomes. TcPO2 significantly increased immediately post‐procedure, then gradually, whereas the FLIR thermography values plateaued from day 1 to 28 post‐procedure. In conclusion, FLIR thermography is a viable non‐invasive tool for evaluating lower limb perfusion based on angiosomes, comparable with TcPO2.
Microstructure and physical properties of Sr2CrHfO6 ferrimagnetic double‐perovskite oxides
Authors: Tang Qingkai , Zhu Xinhua 
Published: October 2023

AbstractHalf‐metallic ferromagnets (HMFs) are highly desirable materials for applications in spintronics because of their semiconducting behavior for one spin projection and metallic nature for the other. To operate spintronic devices at room temperature (RT), HMFs should simultaneously have a large saturation magnetization (MS), high magnetic Curie temperature (TC), and a wide half‐metallic gap. However, HMFs that simultaneously fulfill these three criteria are rare. In this work, we report for the first time on the ferrimagnetic double perovskite oxides of Sr2CrHfO6 (SCHO) with a magnetic TC up to 545 K due to the strong Cr3+(↑)Cr4+(↓) antiferromagnetic spin interactions. The combined experimental results confirmed that the SCHO powders crystallized in an orthogonal crystal structure with Pnma symmetry. The SEM images demonstrate that the powders exhibit a spherical morphology with particle sizes between 150 and 250 nm. XPS spectra verified the presence of Sr2+, Cr 3+/Cr4+, and Hf4+/Hfx+ (x < 4) ions in the SCHO powder. Oxygen was present as lattice oxygen and adsorbed oxygen species. At 2 K, the SCHO powder exhibited ferrimagnetic behavior with MS of 0.11 μB/f. u and a magnetic coercive field of 290 Oe. The SCHO ceramics displayed a normal butterfly‐like magnetoresistance‐magnetic field (MR‐H) curve at 2 K due to the intergranular tunneling effect, and the MR (2 K, 7 T) value was −2.05%. The temperature dependence of the resistivity of the SCHO ceramics revealed their semiconducting nature, and the electrical transport data in the temperature range 2−800 K were well fitted by the Mott's variable‐range hopping model, thermal activation model, and small polaron hopping model. Optical measurements demonstrate that the SCHO powders have a direct optical bandgap of 2.25 eV in the visible light window. Having both high TC and a direct optical bandgap (2.25 eV) makes SCHO oxides attractive for use in advanced spintronic devices and solar cells.
Effect of ZnSnO3 on dielectric and ferroelectric properties of Sr2Bi4Ti5O18 ceramics
Authors: Bhimireddi Rajasekhar , Dhavala Lokeswararao , Shet Tukaram , Sadhu Sai Pavan Prashanth , Kandula Kumara Raja , Ansari Anees A. , Padarti Jeevan Kumar 
Published: October 2023

AbstractSr2Bi4Ti5O18 is one of the promising candidates for ferroelectric nonvolatile random access memory device applications. Albeit, this ceramic material is not suitable for certain ferroelectric device applications because of the merits and demerits associated with this material. Solid‐solution or composite ceramics in bulk configuration is the better choice to overcome the drawbacks associated with the individual compounds. Concurrently, solid‐solution of functional electro‐ceramics comprising Aurivillius family‐based lead‐free bismuth‐layered structured ceramics (1 − x) Sr2Bi4Ti5O18 (SBT) and x mol% of ilmenite structured ZnSnO3 (ZS) (where x = 0, 5, 10, and 20 mol%) were synthesized via conventional solid‐state reaction route to investigate the effect of ZS on the physical properties of SBT. X‐ray diffraction diffractograms revealed that a single phase was formed maximum up to 5 mol% of ZS in SBT and scanning electron microscopy studies suggested platelike microstructure of the samples. Intriguingly, positive‐up and negative‐down results indicated that the true switchable polarization for the 10 mol% ZS in SBT (10.87 μC/cm2), 33% higher than that of pure SBT ceramics in addition to the lower leakage current density and enhanced dielectric response in the SBT–ZS samples. The observed enhancement in electrical characteristics of SBT–ZS composite ceramics compared to pure SBT highlights the decisive role played by the ZS in lowering the thermodynamic barrier resulting in ease of polarization switching and mitigating the leakage current of SBT ceramics.
The Tyranny of Political Correctness? A Game‐Theoretic Model of Social Norms and Implicit Bias
Authors: Berndt Rasmussen Katharina , Olsson Yaouzis Nicolas 
Published: October 2023

ABSTRACTThis article sets out to describe and solve two puzzles that emerge in segregated labour markets (e.g. the USA or Sweden). First, in many hiring contexts people profess to adhere to egalitarian norms, and specifically to a qualification norm according to which job qualification should be the basis of employment. Still there is evidence of frequent norm violations (discrimination). Surprisingly, the norm persists and people do not frequently protest against such norm violations. The second puzzle is that people are suspicious of the hiring of minorities, perceiving such hirings as evidence that a ‘political correctness’ norm has replaced the qualification norm. The article proposes that both puzzles can be solved within a game‐theoretical model of social norm‐following, where implicit bias is introduced into an ‘employment game’. Within this model, implicit bias plays a double role. First, it interferes with employers' hiring decisions regarding ethnic majority and minority members, respectively. This is the standard way of understanding the effects of implicit bias. Second, implicit bias interferes with bystander evaluations of hired candidates' qualifications. This is a hitherto overlooked effect of implicit bias. The article concludes that once we understand the double role of implicit bias, the two puzzles are resolved.
Genetic evaluation of gestation length in Italian Holstein breed
Authors: Galluzzo Ferdinando , Visentin Giulio , van Kaam Johannes B. C. H. M. , Finocchiaro Raffaella , Biffani Stefano , Costa Angela , Marusi Maurizio , Cassandro Martino 
Published: October 2023

AbstractGestation length (GL) can potentially affect health and performance of both the dam and the newborn calf, and it is controlled by two genetic components, direct and maternal. This means that both the calf (direct effect) and the cow (maternal effect) genotypes contribute to determine GL and its variability. The aims of the present study were to estimate direct and maternal variance components of GL, develop a routine genetic evaluation of GL in Italian Holstein and evaluate potential (un)favourable associations with traits for which selection is undertaken in this population. A multiple‐trait repeatability linear animal model was employed for the estimation of variance components considering GL in first and later parities as different traits. The posterior mean (PM) of heritability of the direct effect was 0.43 for first parity and 0.35 for later parities. The PM of heritability of the maternal effect was lower, being 0.08 for primiparae and 0.06 for pluriparae. The posterior standard deviation (PSD) of the heritability estimates was small, ranging from 0.001 to 0.005. The relationship of direct and maternal effects with important traits such as milk yield and fertility indicated that selecting for extreme GL, longer or shorter, may have negative consequences on several traits, suggesting that GL has an intermediate optimum in dairy cattle. In conclusion, this study reveals that selecting an intermediate GL in the Italian Holstein population is advisable. Although scarcely variable compared to other conventional traits for which Italian Holstein is selected, GL is heritable and a deeper knowledge can be useful for decision‐making at the farm level.
Exploring the effects of seductive details and illustration dynamics on young children's performance in an origami task
Authors: Colliot Tiphaine , Boucheix Jean‐Michel 
Published: October 2023

AbstractBackgroundPrevious studies have shown that dynamic illustrations, as compared to their static counterparts, lead to higher achievement levels, especially for hand‐based procedures. Other researchers have investigated how the presence of seductive details (i.e., appealing but irrelevant adjunct displays) influences students' interest positively but their learning negatively.ObjectivesThe purpose of the two present studies was to investigate the effects of animated versus static presentations, combined with the presence of seductive details, on student performance on a paper‐folding task (i.e., origami) in a naturalistic school environment.MethodsFifty‐five children (5–6 years old) participated in the first study and were randomly assigned to one of four groups. The second study was conducted with older children (72 s or third graders) and a more complex origami task.Results and ConclusionsIn the first study, results demonstrated negative effects of seductive details on children's performance and time on task, but no effects of presentation format. In the second study, no negative effects of seductive details on student achievement were found, but animated illustrations significantly improved children's performance and reduced time on task. However, seductive details tended to impair learning more greatly given the presence of static, as compared to animated, presentations. Task difficulties and pupils' ability to inhibit irrelevant information may explain these results.
Relationship between elevated circulating thrombospondin‐1 levels and vascular complications in diabetes mellitus
Authors: Guo Na , Yang Linlin , Wan Xiaozheng , Qiu Dongze , Sun Wenwen , Ma Huijuan 
Published: October 2023

AbstractAims/IntroductionThrombospondin‐1 (TSP‐1) participates in a series of physiological and pathological processes by binding to various receptors regulating cell proliferation, adhesion and apoptosis. Elevated circulating TSP‐1 is linked with diabetic vascular complications (DVC). This study aimed to determine the relationship between circulating TSP‐1 levels and DVC.Materials and MethodsA comprehensive search of PubMed, Embase, Web of Science and CNKI databases was carried out. A meta‐analysis was carried out to compare circulating TSP‐1 levels between diabetes patients without vascular complications (DNVC), diabetes patients with DVC and non‐diabetes patients. The correlation between TSP‐1 and metabolic parameters was also analyzed. Subgroup analysis was carried out according to complication type, defined as diabetic retinopathy, diabetic nephropathy and diabetic cardiovascular disease (DCVD).ResultsA total of eight studies were included. Compared with non‐diabetes patients, diabetic patients, including DNVC and DVC, had significantly higher circulating TSP‐1 levels (standardized mean difference [SMD] 2.660, 95% CI 1.17–4.145, P = 0.000). DNVC had significantly higher circulating TSP‐1 levels than non‐diabetes patients (SMD 3.613, 95% CI 1.607–5.619, P = 0.000). DVC had significantly higher TSP‐1 levels than DNVC (SMD 0.568, 95% CI 0.100–1.036, P = 0.017). TSP‐1 was significantly positively correlated with fasting plasma glucose (overall Fisher's z = 0.696, 95% CI 0.559–0.833) and HbA1c (overall Fisher's z = 0.849, 95% CI 0.776–0.923).ConclusionsElevated circulating TSP‐1 levels are closely related to DVC, especially in diabetic nephropathy and diabetic cardiovascular disease. Circulating TSP‐1 detection might be helpful in the timely diagnosis and treatment of DVC.
Implementing code review in the scientific workflow: Insights from ecology and evolutionary biology
Authors: Ivimey-Cook Edward R. , Pick Joel L. , Bairos-Novak Kevin R. , Culina Antica , Gould Elliot , Grainger Matthew , Marshall Benjamin M. , Moreau David , Paquet Matthieu , Royauté Raphaël , Sánchez-Tójar Alfredo , Silva Inês , Windecker Saras M. 
Published: October 2023

Abstract
Code review increases reliability and improves reproducibility of research. As such, code review is an inevitable step in software development and is common in fields such as computer science. However, despite its importance, code review is noticeably lacking in ecology and evolutionary biology. This is problematic as it facilitates the propagation of coding errors and a reduction in reproducibility and reliability of published results. To address this, we provide a detailed commentary on how to effectively review code, how to set up your project to enable this form of review and detail its possible implementation at several stages throughout the research process. This guide serves as a primer for code review, and adoption of the principles and advice here will go a long way in promoting more open, reliable, and transparent ecology and evolutionary biology.
Abstract
Code review is the process of either informally (as part of a group, as colleagues) or formally (as part of the peer review process) checking and evaluating each other's code and is a critical method of reducing errors and increasing research reproducibility and reliability. In this paper, we provide a detailed commentary on how to effectively review code (including introducing the four Rs), how to set up your project to enable this form of review and detail its possibleimplementation at several stages throughout the research process.