bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases
Authors: Méric Tristan , Issard Julien , Maufras Thomas , Hugonnard Marine , Senecat Odile , Lecoindre Alexis , Leal Rodolfo Oliveira , Bertolani Coralie , Toulza Olivier , Lecoindre Patrick , Brisebard Elise , Ledevin Mireille , Larcher Thibaut , Drut Amandine , Darnis Elodie , Hernandez Juan 
Published: September 2023

AbstractBackgroundCompared to humans, colorectal polyps are relatively rare in dogs. Epidemiological and prognostic data remain accordingly sparse, although they could help veterinary clinicians in the management of these cases.ObjectivesTo report the epidemiological data of dogs with colorectal polyps and identify factors associated with recurrence and survival.AnimalsFifty‐eight client‐owned dogs with colorectal polyps admitted to 7 veterinary hospitals (53 dogs from France, 5 dogs from Spain, and 4 dogs from Portugal) were included.MethodsRetrospective multicentric cohort study. Medical records and long‐term outcome of the dogs were reviewed. When available, histological samples were reassessed by 2 board‐certified pathologists according to the revised Vienna classification (RVC).ResultsThe West Highland White Terrier (WHWT) breed was significantly associated with the presence of colorectal polyps (OR: 20; 95% CI: 7.5‐52; P < .001). The overall median time to recurrence was not reached after 2000 days. The overall estimated median survival time was 1640 days. WHWT breed and larger polyps were significantly associated with a shorter time of polyp recurrence after surgical removal (respectively, P = .05 and P = .01).Conclusions and Clinical ImportanceThe probability of recurrence of colorectal polyps in dogs is low, but increased in WHWTs and larger polyps, which might benefit from routine screening after removal. No effective predictors of polyp recurrence and survival were identified using the RVC.
Quality of life at work and fatigue after hospitalization due to COVID‐19
Authors: Mazurkiewicz Iwona , Chatys‐Bogacka Zaneta , Slowik Joanna , Szaleniec Joanna , Czepiel Jacek , Slowik Agnieszka , Drabik Leszek , Wnuk Marcin 
Published: September 2023

AbstractObjectiveTo evaluate course of quality of life (QoL) after hospitalization due to COVID‐19 and to assess whether symptoms of chronic fatigue syndrome (CFS) were its predictors at different time points.MethodsParticipants aged 18 or older retrospectively reported QoL at work with 4‐point Likert scale and presence of eight CFS symptoms before infection, within 0–4, 4–12, and > 12 weeks post‐COVID with online or paper version of validated neuropsychological questionnaire.ResultsTwo hundred and eighty‐three patients (median age 59 [47–67] years, 37.45% women, 95.76% non‐ICU residents) were evaluated after median of 27.1 (24.9–31.6) weeks from first positive swab test for SARS‐CoV‐2. Any decrease in QoL at work was observed in 33.21%, 29.28%, and 25.54% of patients within 4, 4–12, and > 12 weeks after COVID‐19, respectively (p < 0.001). Within 4 weeks after COVID‐19 onset, decrease in QoL at work was predicted by age (OR = 0.93, 95% CI:0.90–0.96, p < 0.001), persistent fatigue unrelated to effort (OR = 4.03, 95% CI:1.21–13.50, p < 0.001), sore throat (OR = 5.33, 95% CI:1.92–14.78, p = 0.001), and prolonged post‐exercise fatigue (OR = 8.12, 95% CI:2.17–30.56, p = 0.002). Predictors of deterioration in QoL at work 4–12 and > 12 weeks post‐infection were age (OR = 0.97, 95% CI:0.94–0.99, p = 0.015 and OR = 0.93, 95% CI:0.90–0.97, p = 0.001, respectively), non‐restorative sleep (OR = 2.75, 95% CI:1.25–6.05, p = 0.012 and OR = 3.62, 95% CI:1.40–9.38, p = 0.008, respectively), and headache (OR = 2.78, 95% CI:1.29–5.99, p = 0.009 and OR = 5.68, 95% CI:2.15–15.02, p < 0.001, respectively). Furthermore, decreased QoL at work was predicted by post‐exercise fatigue (OR = 5.99, 95% CI:2.18–16.20, p < 0.001) and fatigue not caused by effort (OR = 14.40, 95% CI:4.77–43.45, p < 0.001) within 4–12 and > 12 weeks post‐infection, respectively.ConclusionsDifferent CFS symptoms are associated with decreased QoL at work at various time points since COVID‐19 onset.
A systemized strategy to reduce door‐to‐puncture time using the ELVO screen: “Code AIS”
Authors: Inoue Hiroyasu , Nishikawa Yusuke , Oomura Masahiro , Hattori Tomonori , Hayashi Yuki , Yamanaka Tomoyasu , Uchida Mitsuru , Taniguchi Yoko , Suzuki Kengo , Madokoro Yuta , Sato Toyohiro , Fujioka Teppei , Mizuno Masayuki , Kawashima Shoji , Okita Kenji , Mase Mitsuhito , Matsukawa Noriyuki 
Published: September 2023

AbstractBackgroundA shorter onset‐to recanalization (O2R) time in mechanical thrombectomy for acute ischemic stroke (AIS) results in better outcomes. Thus, we should reduce the door‐to‐puncture (D2P) time.AimTo evaluate the effectiveness of a triage system named “Code AIS.” We adopted the emergency large vessel occlusion (ELVO) screen as a screening test.MethodsUsing the ELVO screening test, Code AIS was invoked when ≥1 positive results were obtained without witnessed seizures. The Code AIS system requires the assembly of neurologists, neurosurgeons, and an endovascular team in the emergency department before a patient arrives at the hospital. In total, 104 consecutive patients who underwent thrombectomy after emergency transport from January 2015 to December 2022 were included. The Code AIS system was initiated on February 17, 2022, and patients were divided into the pre‐Code AIS and Code AIS era groups. D2P time, outcome, and other parameters were compared between the groups.ResultsEighty‐eight and 16 cases were in the pre‐Code AIS and Code AIS era groups, respectively. Background factors, including age, sex, and etiology, did not differ between the groups. The median (interquartile range) time of D2P in the Code AIS era was 60 (41–102) min and significantly shortened compared to 135 (109–161) min in the pre‐Code AIS era (p < 0.001). The proportion of patients with favorable outcomes (modified Rankin Scale score, 0–2) improved significantly from 33% (pre‐Code AIS era) to 63% (Code AIS era) (p = 0.047).ConclusionUsing Code AIS, we succeeded in shortening D2P time and improving patient outcomes.
Association between dietary factors, symptoms, and psychological factors in adults with dyspepsia: A cross‐sectional study
Authors: Cooke Zoe M. , Resciniti Stephanie M. , Wright Bradley J. , Hale Matthew W. , Yao Chu K. , Tuck Caroline J. , Biesiekierski Jessica R. 
Published: September 2023

AbstractBackgroundEvidence‐based dietary management approaches for symptoms of dyspepsia are lacking. This study aimed to compare dietary factors, symptoms, quality of life (QOL) and salivary cortisol in dyspepsia participants and healthy controls.MethodsA cross‐sectional survey was completed by adults with dyspepsia (n = 121) meeting Rome IV criteria and healthy controls (n = 52). Outcome measures included self‐reported questionnaires about dietary habits, triggers, restrictions, dietary management approaches, nutritional intake, psychological variables, QOL, gastrointestinal symptoms, and optional cortisol awakening response (CAR) via saliva samples. Data were analyzed using Chi‐square or Mann–Whitney U. Cortisol awakening response data was analyzed using moderated regression controlling for age, gender and distress.Key ResultsFermentable carbohydrates (FODMAPs) (55%) were the most reported trigger in adults with dyspepsia. The dyspepsia group (88%) followed special diets more than controls (47%; p < 0.001), with a low FODMAP diet being most common (69%). The dyspepsia group consumed less fiber (p = 0.014), calcium (p = 0.015), and total FODMAPs (p < 0.001) than controls. There was a greater prevalence of comorbid anxiety (41%) and depression (31%) in dyspepsia compared to controls (15% and 12%, respectively, p < 0.001 and p = 0.006). The dyspepsia group had poorer QOL and greater gastrointestinal symptom severity than controls (p < 0.001). There was a negative association between anxiety and CAR (p = 0.001) in dyspepsia but not in controls.Conclusions & InferencesAdults with dyspepsia follow special diets more than controls and perceive FODMAPs as a key dietary trigger. These findings highlight the importance of monitoring nutritional adequacy and QOL, and emphasize mechanisms of depleted stress response in dyspepsia, warranting further exploration.
Assessing the Casual Association between Sex Hormone Levels and Fracture Risk: A Two‐Sample Mendelian Randomization Study
Authors: Sun Kaibo , Ming Yue , Xu Jiawen , Wu Yuangang , Zeng Yi , Wu Limin , Li Mingyang , Shen Bin 
Published: September 2023

ObjectivePrior observational studies have reported that levels of sex hormones constitute a risk factor for the fracture. The aim of this study was to ascertain whether there is a causal relationship between the levels of sex hormones and the risk of fracture through Mendelian randomization (MR).MethodsSingle‐nucleotide polymorphisms (SNPs) associated with two indicators of sex hormone levels, circulating sex hormone‐binding globulin (SHBG) and bioavailable testosterone levels, as exposures were selected from a large genome‐wide association study (GWAS) from UK Biobank. The summary statistics for 11 different types of fracture as outcomes from the FinnGen consortium. This study employed the two‐sample MR approach. For the main analysis, the inverse‐variance‐weighted (IVW) method was utilized. To assess the heterogeneity of MR results, the IVW method and MR–Egger method were utilized. To evaluate potential pleiotropy, MR–Egger regression was conducted. Additionally, a leave‐one‐SNP‐out test was performed to assess the robustness of MR results to the exclusion of any individual SNP.ResultsThe MR analyses demonstrated a conspicuous impact of SHBG on the risk of pathological fracture with osteoporosis (OP). We found that an increase of one standard deviation (SD) in SHBG correspondingly increased the risk of pathological fracture with OP [odds ratio (OR) 2.42, 95% confidence interval (CI), 1.52–3.85; p = 1.93 × 10−4]. The bioavailable testosterone showed the negative casual genetic associations with fractures of foot and forearm. An increase of one SD in the genetically predetermined bioavailable testosterone was associated with a reduction of 37% in the risk of fracture of foot (OR 0.63, 95% Cl 0.49 to 0.81; p = 3.37 × 10−4), as well as a 39% decrease in the risk of fracture of forearm (OR 0.61, 95% Cl 0.50 to 0.76; p = 5.40 × 10−6).ConclusionsOur study confirms that individuals experiencing elevated SHBG concentrations showed a major causal effect on pathological fracture with OP. High bioavailable testosterone levels play an important role in preventing the fractures of foot and forearm. Although increasing bioavailable testosterone and decreasing SHBG levels had no casual effect on most fractures in the general population, they are likely to have the most clinically relevant effect on certain fracture risk reduction.
The accuracy of the ultrasound measured transverse cricoid diameter and the epiphyseal transverse diameter of the distal radius in predicting the pediatric endotracheal tube size
Authors: Abdel‐Ghaffar Hala Saad , Thabet Omnia Hussein , Abbas Yara Hamdy , El‐hagagy Noha Yahia Mohammd , Abedalmohsen Abualauon Mohamed 
Published: September 2023

AbstractBackgroundIn everyday pediatric anesthesia practice, clinicians frequently exchange an already inserted endotracheal tube because of a leak or resistance causing significant morbidity. We investigated the accuracy of two ultrasound measurements; the transverse cricoid diameter and epiphyseal diameter of the distal radius in the prediction of endotracheal tube size that best fits in children compared to age‐based formulas.PatientsOne hundred children (1–6 years) who underwent elective surgery with endotracheal tube whether cuffed (n = 50) or uncuffed (n = 50) were enrolled. The primary endpoint was the agreement between the reference tube size for which its outer diameter was selected based on transverse cricoid diameter and the final best‐fit‐ETT. The Correlation and Bland Altman agreement tests were conducted between best‐fit‐ETT outer diameter and ultrasound‐measured outer diameter, and between best‐fit‐ETT inner diameter and inner diameter calculated by age‐based formulas.ResultsThe agreement rate between transverse cricoid diameter‐based endotracheal tube size and best‐fit‐ETT size was 88% in cuffed group compared to 90% in uncuffed group. A significant positive correlation was reported between the outer diameter of best‐fit‐ETT and the outer diameter measured by the two ultrasound methods. A lower degree of positive correlation was reported between the inner diameter of best‐fit‐ETT, and the inner diameter calculated by age‐based formulas. Bland Altman's analysis showed agreement between best‐fit‐ETT outer diameter and epiphyseal diameter of the distal radius in both groups and with transverse cricoid diameter in the cuffed group, with no agreement with age‐based formulas in either group.ConclusionsBoth transverse cricoid diameter and epiphyseal diameter of the distal radius are reliable predictors of the size of best‐fit‐ETT pediatric endotracheal tube compared to age‐based formulas. To save time and effort, we recommend the US measurement of the epiphyseal diameter of distal radius in the preoperative visit and documenting the predicted tube size with the preoperative assessments.
Give, take, or match? Styles of reciprocity, job satisfaction, and work motivation
Authors: Belle Nicola , Cantarelli Paola 
Published: September 2023

AbstractIn four online experiments involving 16,461 public professionals, we examined the causal effects of reciprocity styles at work on colleagues' expected job satisfaction and motivation. Our findings indicate that giving, which involves helping others when the benefit outweighs personal cost, is the supervisory reciprocity style that maximizes expected satisfaction among subordinates (Study 1). Additionally, it is expected that public employee motivation will be highest when their supervisor or colleagues exhibit a giving reciprocity style. Interestingly, the positive motivational effect of a giving peer is found to be relatively larger than that of a giving supervisor (Study 2). Furthermore, the expected motivation of current team members is enhanced by the prospect of a giver joining their unit, while the arrival of a taker (someone who only helps if the benefits exceed personal costs) reduces colleagues' motivation compared to the departure of a taker (Study 3).
Development of a panel for detection of pathogens in xenotransplantation donor pigs
Authors: Otabi Hikari , Miura Hiroto , Uryu Haruka , Kobayashi‐Harada Rana , Abe Kanako , Nakano Kazuaki , Umeyama Kazuhiro , Hasegawa Koki , Tsukahara Takamitsu , Nagashima Hiroshi , Inoue Ryo 
Published: September 2023

AbstractThere have been high expectations in recent years of using xenotransplantation and regenerative medicine to treat humans, and pigs have been utilized as the donor model. Pigs used for these clinical applications must be microbiologically safe, that is, free of infectious pathogens, to prevent infections not only in livestock, but also in humans. Currently, however, the full spectrum of pathogens that can infect to the human host or cause disease in transplanted porcine organs/cells has not been fully defined. In the present study, we thus aimed to develop a larger panel for the detection of pathogens that could potentially infect xenotransplantation donor pigs. Our newly developed panel, which consisted of 76 highly sensitive PCR detection assays, was able to detect 41 viruses, 1 protozoa, and a broad range of bacteria (by use of universal 16S rRNA primers). The applicability of this panel was validated using blood samples from uterectomy‐born piglets, and pathogens suspected to be vertically transmitted from sows to piglets were successfully detected. We estimate that, at least for viruses and bacteria, the number of target pathogens detected by the developed screening panel should suffice to meet the microbiological safety levels required worldwide for xenotransplantation and/or regenerative therapy. This panel provides greater diagnosis options to produce donor pigs so that it would render unnecessary to screen for all pathogens listed. Instead, the new panel could be utilized to detect only required pathogens within a given geographic range where the donor pigs for xenotransplantation have been and/or are being developed.
Filling the gaps in the Argentinian distribution of orthohantavirus: First finding of Lechiguanas virus in rodents from Corrientes, Argentina
Authors: Gómez Villafañe Isabel E. , Bellomo Carla M. , Rospide Malena , Blanco Paula , Coelho Rocío , Alonso Daniel O. , Arnica Diana , Sanchez Loria Julián , Figini Iara , Campos Josefina , Martínez Valeria P. , Orozco María Marcela 
Published: September 2023

AbstractHantavirus Pulmonary Syndrome (HPS) is an emerging infectious disease caused by orthohantaviruses in the Americas. In Argentina, since 1995, several reservoirs and virus variants have been described, but the northeastern and central endemic zones in the country include an area without human or rodent infections, despite sharing rodent species with areas with that disease. The aim of this study was to search for orthohantavirus in rodent communities that inhabit this area, which borders two endemic areas of HPS. Small rodents were captured in June of 2022 through a total effort of 644 trap nights distributed in five grids located in the Iberá National Park, Corrientes, Northeastern Argentina. All rodents were sexed, weighed, and the species was recorded. Blood samples were extracted to detect ANDV‐specific immunoglobulin G (IgG), and to extract the RNA virus. Trimmed sequences were mapped against reference sequences from GenBank. We captured a total of 36 Oligoryzomys flavescens and 15 Oxymycterus rufus. We detected the O. flavescens species infected with Lechiguanas orthohantavirus in the camping area of the National Park. A nucleotide comparison with previously published sequences shows a 98.34% similarity to the virus obtained from a human case of HPS reported in the adjacent Misiones province. This study demonstrated, for the first time, that O. flavescens is a host of the Lechiguanas orthohantavirus in this zone and contributes to closing information gaps on the distribution of orthohantavirus in Argentina. Additionally, the high similarity with the hantavirus found in the human case of Misiones suggests that the reservoir in that province would also be O. flavescens (not previously confirmed). This information permits us to focus on the preventive measurements to protect the human population.
Panic-Pressure Conversion Model From Microscopic Pedestrian Movement to Macroscopic Crowd Flow
Authors: Zhu Wenjie , Zhao Rongyong , Zhang Hao , Li Cuiling , Jia Ping , Ma Yunlong , Wang Dong , Li Miyuan 
Published: September 2023

Abstract
Understanding the effects of panic on crowd dynamics in emergency situations has long been considered necessary for pedestrian evacuation control. In the case of disasters, stampedes caused by panic behaviors occur with high possibility, and pedestrians are crushed or trampled, leading to enormous casualties. To eliminate the computational errors accumulated in the traditional macromodel, a macro-microconversion model based on the SF (social force) model and the AR (Aw-Rascle) model is proposed in this paper. The purpose is to use the crowd parameters of the microscopic model as the input part of the macroscopic model and to combine the advantages of the two models to ensure accuracy and improve calculation performance. The concept of the “pressure term” is defined to measure the panic level of the crowd. In addition, a flowchart of the numerical simulation is designed based on the road network conditions at the trampling site. To validate the conversion model, a numerical simulation is conducted in a case study of the Mecca Hajj stampede in 2015. The simulation results display the whole process of crowd marching and meeting with the dynamic variations of the “pressure term.” The simulation results are compared with the traditional simulation results based on a Gaussian distribution, which verifies that the simulation results obtained by the proposed method are closer to the real situation. Moreover, in this study, a new micromacro transformation method for crowd evaluation dynamics, which can enhance computing speed and execution efficiency, is provided.
Multi-Objective Experimental Combustor Development Using Surrogate Model-Based Optimization
Authors: Reumschüssel Johann Moritz , von Saldern Jakob G. R. , Ćosić Bernhard , Paschereit Christian Oliver 
Published: September 2023

Abstract
The majority of premixed industrial gas turbine combustion systems feature two or more separately controlled fuel lines. Every additional fuel line improves the operational flexibility but increases the complexity of the system. When designing such a system, the goals are low emissions of various pollutants and avoiding lean blowout or extinction. Typically, these limitations become critical under different load conditions of the machines. Therefore, it is particularly challenging to develop combustors for stable and clean combustion over a wide operating range. In this study, we apply the Gaussian process regression machine learning method for application to burner development, with the aim of improving the process, which is often driven by a trial-and-error approach. To do so, a special pilot unit is installed into a full-scale industrial swirl combustor. The pilot features 61 positions of fuel injection, each of which is equipped with an individual valve, allowing to modify the fuel–air mixture close to the flame root in various degrees. In fully automatized atmospheric tests, we use the pilot system to train two surrogate models for different design objectives of the combustor, relevant for full load and part load operation, respectively. Once trained, the models allow for prediction for any possible injection scheme. In combination, they can be used to identify pilot injector configurations with an improved operation range in terms of low NOx emissions and part load stability. The adopted multimodel approach enables combustor design specifically for high operational flexibility of gas turbines, but can also be extended to other similar industrial development processes.
Predicting Premature Failures in Small Wind Turbines With Recurrence Plots
Authors: Jauregui Juan C. , Torres-Contreras Ignacio 
Published: September 2023

Abstract
This paper presents the application of the recurrence plot as an alternative for preprocessing the raw data. The recurrence plots can extract the nonlinear and transient response and are sensitive to slight variations in the signal frequency, amplitude, and waveform. Thus, it is an alternative technique for improving the sensitivity; consequently, the prognostic algorithms can predict with better resolution. The data were obtained from an experimental 12 m wind turbine. The transmission was instrumented with three accelerometers and three gyroscopes; the generator's current and voltage were monitored. The difficulty in producing the phase plane using acceleration data is its integration to obtain the kinetic and potential signal energies. This limitation is overcome by integrating the data using the empirical mode decomposition and the shift principle. The results show good sensitivity for predicting variations in the operating conditions and are the basis for other prognostic analyses.