bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation and the effects of a Parkinson Network Therapy (PaNTher) on activities of daily living and health-related quality of life in Parkinson’s disease patients: study protocol of an mixed-method observational cohort study in outpatient care
Authors: Loidl Verena , Ziegler Kerstin , Hoppmann Dagmar , Wagner Christian , Fietzek Urban M , Ceballos-Baumann Andrés O , Grill Eva 
Published: November 2023

IntroductionParkinson’s disease (PD) represents the fastest growing neurodegenerative disease with an increasing prevalence worldwide. It is characterised by complex motor and non-motor symptoms that lead to considerable disability. Specialised physiotherapy has been shown to benefit patients with PD. TheParkinson Netzwerk Therapie(PaNTher) was created to improve access to specialised physiotherapy tailored to care priorities of PD patients. This study aims to evaluate the effectiveness, acceptability and needs of the PaNTher network by neurologists and physiotherapists involved in the network in outpatient care.Methods and analysisThis is a mixed-method, prospective, pragmatic non-randomised cohort study of parallel groups, with data collection taking place in Bavaria, Germany, between 2020 and 2024. Patients with PD insured by theAllgemeine Ortskrankenkasse Bayern(AOK Bayern) living in Bavaria will be recruited for study participation by network partners. Patients in the intervention group must reside in Munich or the surrounding area to ensure provision of specialised physiotherapy in close proximity to their place of residence. Controls receive care as usual. Six and 12 months after baseline, all patients receive a follow-up questionnaire. Mixed-effect regression models will be used to examine changes in impairment of activities of daily living and quality of life of patients with PD enrolled in the programme over time compared with usual care. Qualitative interviews will investigate the implementation processes and acceptability of the PaNTher network among neurologists and physiotherapists. The study is expected to show that the PaNTher network with an integrative care approach will improve the quality and effectiveness of the management and treatment of patients with PD.Ethics and disseminationThe study has been approved by the ethics committee at the medical faculty of the Ludwig-Maximilians-University Munich (20-318). Results will be published in scientific, peer-reviewed journals and presented at national and international conferences.
Optimising scale-up for public health impact: a multimethod implementation science research protocol to improve infant health outcomes in Ethiopia
Authors: Hakizimana Dieudonne , Shitu Kegnie , Rankin Katherine C , Alemie Getahun A , Walson Judd , Guthrie Brandon L , Means Arianna Rubin 
Published: November 2023

IntroductionChild mortality rates remain high in sub-Saharan Africa, including Ethiopia. We are conducting a cluster randomised control trial in the Gondar zone of the Amhara region to determine the impact of pairing Orthodox priests with community health workers, known locally as the Health Development Army (HDA), on newborns’ nutritional status, early illness identification and treatment, and vaccination completeness.Ensuring intervention efficacy with scientific rigour is essential, but there are often delays in adopting evidence into policy and programmes. Here, we present a protocol for conducting parallel implementation research alongside an efficacy study to understand intervention implementability and scalability. This will help develop a scale-up strategy for effective elements of the intervention to ensure rapid implementation at scale.Methods and analysisWe will conduct a stakeholder analysis of key implementation stakeholders and readiness surveys to assess their readiness to scale up the intervention. We will conduct semistructured interviews and focus group discussions with stakeholders, including HDA members, health workers, Orthodox priests, and caregivers, to determine the core intervention elements that need to be scaled, barriers and facilitators to scaling up the intervention in diverse sociocultural settings, as well as the human and technical requirements for national and regional implementation. Finally, to determine the financial resources necessary for sustaining and scaling the intervention, we will conduct activity-based costing to estimate implementation costs from the provider’s perspective.Ethics and disseminationThe study received approval from the University of Gondar Institutional Review Board (approval no: VP/RTT/05/1030/2022) and the University of Washington Human Subjects Division (approval no: STUDY00015369). Participants will consent to participate. Results will be disseminated through workshops with stakeholders, local community meetings, presentations at local and international conferences, and journal publications. The study will provide evidence for factors to consider in developing a scale-up strategy to integrate the intervention into routine health system practices.
Association of serum potassium level with dietary potassium intake in Chinese older adults: a multicentre, cross-sectional survey
Authors: Yuan Yifang , Jin Aoming , Zhao Ming-Hui , Wang Hongxia , Feng Xiangxian , Qiao Qianku , Zhang Ruijuan , Gao Runlin , Wu Yangfeng 
Published: November 2023

ObjectivesEvidence linking dietary potassium and serum potassium is virtually scarce and inconclusive. The aim of the study was to investigate the association between serum potassium level and potassium intake measured by 24-hour urine. We also explored whether the association differed across health conditions.DesignA cross-sectional study conducted from September 2017 to March 2018.Setting48 residential elderly care facilities in northern China.ParticipantsParticipants aged 55 years and older and with both serum potassium and 24-hour urinary potassium measured were classified as having a low (apparently healthy), moderate (with ≥1 health condition but normal renal function) and high (with ≥1 health condition and abnormal renal function) risk of hyperkalaemia.ExposurePotassium intake is measured by 24-hour urinary potassium.OutcomesSerum potassium in association with potassium intake after adjustment for age, sex, region and accounting for the cluster effect.ResultsOf 962 eligible participants (mean age 69.1 years, 86.8% men), 17.3% were at low risk, 48.4% at moderate risk and 34.3% at high risk of hyperkalaemia. Serum potassium was weakly associated with 24-hour urinary potassium among individuals with moderate (adjusted β=0.0040/L; p=0.017) and high (adjusted β=0.0078/L; p=0.003) but not low (adjusted β=0.0018/L; p=0.311) risk of hyperkalaemia.ConclusionsA weak association between dietary potassium intake and serum potassium level existed only among individuals with impaired renal function or other health conditions but not among apparently healthy individuals. The results imply that increasing dietary potassium intake may slightly increase the risk of hyperkalaemia but may also decrease the risk of hypokalaemia in unhealthy individuals, both of which have important health concerns.Trial registration numberNCT03290716; Post-results.
Outcomes of mechanical thrombectomy in stroke patients with extreme large infarction core
Authors: Almallouhi Eyad , Zandpazandi Sara , Anadani Mohammad , Cunningham Conor , Sowlat Mohammad-Mahdi , Matsukawa Hidetoshi , Orscelik Atakan , Elawady Sameh Samir , Maier Ilko , Al Kasab Sami , Jabbour Pascal , Kim Joon-tae , Wolfe Stacey Q , Rai Ansaar , Starke Robert M , Psychogios Marios-Nikos , Samaniego Edgar A , Arthur Adam S , Yoshimura Shinichi , Cuellar Hugo , Grossberg Jonathan A , Alawieh Ali , Romano Daniele G , Tanweer Omar , Mascitelli Justin , Fragata Isabel , Polifka Adam J , Osbun Joshua W , Crosa Roberto Javier , Matouk Charles , Park Min S , Levitt Michael R , Brinjikji Waleed , Moss Mark , Dumont Travis M , Williamson Richard , Navia Pedro , Kan Peter , De Leacy Reade , Chowdhry Shakeel A , Ezzeldin Mohamad , Spiotta Alejandro M 
Published: November 2023

Background
Recent clinical trials have demonstrated that patients with large vessel occlusion (LVO) and large infarction core may still benefit from mechanical thrombectomy (MT). In this study, we evaluate outcomes of MT in LVO patients presenting with extremely large infarction core Alberta Stroke Program Early CT Score (ASPECTS 0–2).

Methods
Data from the Stroke Thrombectomy and Aneurysm Registry (STAR) was interrogated. We identified thrombectomy patients presenting with an occlusion in the intracranial internal carotid artery (ICA) or M1 segment of the middle cerebral artery and extremely large infarction core (ASPECTS 0–2). A favorable outcome was defined by achieving a modified Rankin scale of 0–3 at 90 days post-MT. Successful recanalization was defined by achieving a modified Thrombolysis In Cerebral Ischemia (mTICI) score ≥2B.

Results
We identified 58 patients who presented with ASPECTS 0–2 and underwent MT. Median age was 74.0 (66.3–80.0) years, 30 (51.7%) were females, and 16 (27.6%) patients received intravenous tissue plasminogen activator. There was no difference regarding the location of the occlusion (p=0.57). Aspiration thrombectomy was performed in 34 (64.2%) patients and stent retriever was used in 8 (15.1%) patients. In patients presenting with ASPECTS 0-2 the mortality rate was 41.4%, 31% had mRS 0-3 at day 90, 66.67% ≥70 years of age had mRS of 5-6 at day 90. On multivariable analysis, age, National Institutes of Health Stroke Scale on admission, and successful recanalization (mTICI ≥2B) were independently associated with favorable outcomes.

Conclusions
This multicentered, retrospective cohort study suggests that MT may be beneficial in a select group of patients with ASPECTS 0–2.
New dark matter candidate in the $$B-L$$ symmetric SSM
Authors: Yang Jin-Lei , Yang Zhong-Jun , Yang Xiu-Yi , Zhang Hai-Bin , Feng Tai-Fu 
Published: November 2023

AbstractThe B-L symmetric SUSY model (B-LSSM) introduces a new $$Z'$$

Z
′

gauge boson and two singlet scalars, which indicates there are more neutralinos in the B-LSSM comparing with the minimal SUSY extension of standard model (MSSM). These new neutralinos provide more dark matter (DM) candidates in the B-LSSM, we find that the super partner of the new scalar singlet can serve as the lightest supersymmetric particle (LSP) and be considered as a DM candidate. The properties of this new DM candidate are analyzed in this work. Taking into account the experimental constraints on Higgs boson mass, B meson rare decays and muon anomalous magnetic dipole moment, the numerical results are obtained and presented. The properties of new DM candidate in the B-LSSM satisfy the observed relic density $$\Omega h^2$$

Ω

h
2

and comply with the latest upper bounds on $$\sigma _\textrm{SI}^{\chi _1^0-n}$$

σ
SI

χ
1
0

-
n

, and its mass is expected to greater than $$80\;\textrm{GeV}$$

80

GeV

approximately.
$$J/\Psi $$ suppression in a rotating magnetized holographic QGP matter
Authors: Zhao Yan-Qing , Hou Defu 
Published: November 2023

AbstractWe study the dissociation effect of $$J/\Psi $$

J
/
Ψ

in magnetized, rotating QGP matter at finite temperature and chemical potential using gauge/gravity duality. By incorporating angular velocity into the holographic magnetic catalysis model, we analyze the influence of temperature, chemical potential, magnetic field, and angular velocity on the properties of $$J/\Psi $$

J
/
Ψ

meson. The results reveal that temperature, chemical potential, and rotation enhance the dissociation effect and increase the effective mass in the QGP phase. However, the magnetic field suppresses dissociation, and its effect on the effective mass is non-trivial. Additionally, we explore the interplay between magnetic field and rotation, identifying a critical angular velocity that determines the dominant effect. As a parallel study, we also examine the rotation effect in the holographic inverse magnetic catalysis model, although the magnetic field exhibits distinctly different behaviors in these two models, the impact of rotation on the dissociation effect of $$J/\Psi $$

J
/
Ψ

is similar. Finally, we investigate the influence of electric field and demonstrate that it also speeds up the $$J/\Psi $$

J
/
Ψ

dissociation.
Study on the possible molecular states composed of $$\Lambda _c{\bar{D}}^*$$, $$\Sigma _c{\bar{D}}^*$$, $$\Xi _c{\bar{D}}^*$$ and $$\Xi _c'{\bar{D}}^*$$ in the Bethe–Salpeter frame based on the pentaquark states $$P_c(4440)$$, $$P_c(4457)$$ and $$P_{cs}(4459)$$
Authors: Ke Hong-Wei , Lu Fang , Pang Hai , Liu Xiao-Hai , Li Xue-Qian 
Published: November 2023

AbstractThe measurements on a few pentaquarks states $$P_c(4440)$$

P
c

(
4440
)

, $$P_c(4457)$$

P
c

(
4457
)

and $$P_{cs}(4459)$$

P

cs

(
4459
)

excite our new interests about their structures. Since the masses of $$P_c(4440)$$

P
c

(
4440
)

and $$P_c(4457)$$

P
c

(
4457
)

are close to the threshold of $$\Sigma _c{\bar{D}}^*$$

Σ
c

D

¯

∗

, in the earlier works, they were regarded as molecular states of $$\Sigma _c{\bar{D}}^*$$

Σ
c

D

¯

∗

with quantum numbers $$I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$$

I

(

J
P

)

=

1
2

(

1
2

-

)

and $$\frac{1}{2}(\frac{3}{2}^-)$$

1
2

(

3
2

-

)

, respectively. In a similar way $$P_{cs}(4459)$$

P

cs

(
4459
)

is naturally considered as a $$\Xi _c{\bar{D}}^*$$

Ξ
c

D

¯

∗

bound state with $$I=0$$

I
=
0

. Within the Bethe-Salpeter (B-S) framework we systematically study the possible bound states of $$\Lambda _c\bar{D}^*$$

Λ
c

D

¯

∗

, $$\Sigma _c{\bar{D}}^*$$

Σ
c

D

¯

∗

, $$\Xi _c{\bar{D}}^*$$

Ξ
c

D

¯

∗

and $$\Xi _c'{\bar{D}}^*$$

Ξ
c
′

D

¯

∗

. Our results indicate that $$\Sigma _c{\bar{D}}^*$$

Σ
c

D

¯

∗

can form a bound state with $$I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$$

I

(

J
P

)

=

1
2

(

1
2

-

)

, which corresponds to $$P_c(4440)$$

P
c

(
4440
)

. However for the $$I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$$

I

(

J
P

)

=

1
2

(

3
2

-

)

system the attraction between $$\Sigma _c$$

Σ
c

and $${\bar{D}}^*$$

D

¯

∗

is too weak to constitute a molecule, so $$P_{c}(4457)$$

P
c

(
4457
)

may not be a bound state of $$\Sigma _c{\bar{D}}^*$$

Σ
c

D

¯

∗

with $$I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$$

I

(

J
P

)

=

1
2

(

3
2

-

)

. As $$\Xi _c{\bar{D}}^*$$

Ξ
c

D

¯

∗

and $$\Xi _c'{\bar{D}}^*$$

Ξ
c
′

D

¯

∗

systems we take into account of the mixing between $$\Xi _c$$

Ξ
c

and $$\Xi '_c$$

Ξ
c
′

and the eigenstets should include two normal bound states $$\Xi _c{\bar{D}}^*$$

Ξ
c

D

¯

∗

and $$\Xi _c'{\bar{D}}^*$$

Ξ
c
′

D

¯

∗

with $$I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$$

I

(

J
P

)

=

1
2

(

1
2

-

)

and a loosely bound state $$\Xi _c{\bar{D}}^*$$

Ξ
c

D

¯

∗

with $$I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$$

I

(

J
P

)

=

1
2

(

3
2

-

)

. The conclusion that two $$\Xi _c{\bar{D}}^*$$

Ξ
c

D

¯

∗

bound states exist, supports the suggestion that the observed peak of $$P_{cs}(4459)$$

P

cs

(
4459
)

may hide two states $$P_{cs}(4455)$$

P

cs

(
4455
)

and $$P_{cs}(4468)$$

P

cs

(
4468
)

. Based on the computations we predict a bound state $$\Xi _c'{\bar{D}}^*$$

Ξ
c
′

D

¯

∗

with $$I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$$

I

(

J
P

)

=

1
2

(

1
2

-

)

but not that with $$I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$$

I

(

J
P

)

=

1
2

(

3
2

-

)

. Further more accurate experiments will test our approach and results.
Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance
Authors: Echavidre William , Durivault Jérôme , Gotorbe Célia , Blanchard Thays , Pagnuzzi Marina , Vial Valérie , Raes Florian , Broisat Alexis , Villeneuve Rémy , Amblard Régis , Garnier Nicolas , Ortholan Cécile , Faraggi Marc , Serrano Benjamin , Picco Vincent , Montemagno Christopher 
Published: November 2023

Abstract

Medulloblastoma is one of the most prevalent solid tumors found in children, occurring in the brain's posterior fossa. The standard treatment protocol involves maximal resection surgery followed by craniospinal irradiation and chemotherapy. Despite a long-term survival rate of 70%, wide disparities among patients have been observed. The identification of pertinent targets for both initial and recurrent medulloblastoma cases is imperative. Both primary and recurrent medulloblastoma are marked by their aggressive infiltration into surrounding brain tissue, robust angiogenesis, and resistance to radiotherapy. While the significant role of integrin-αvβ3 in driving these characteristics has been extensively documented in glioblastoma, its impact in the context of medulloblastoma remains largely unexplored. Integrin-αvβ3 was found to be expressed in a subset of patients with medulloblastoma. We investigated the role of integrin-αvβ3 using medulloblastoma-derived cell lines with β3-subunit depletion or overexpression both in vitro and in vivo settings. By generating radioresistant medulloblastoma cell lines, we uncovered an increased integrin-αvβ3 expression, which correlated with increased susceptibility to pharmacologic integrin-αvβ3 inhibition with cilengitide, a competitive ligand mimetic. Finally, we conducted single-photon emission computed tomography (SPECT)/MRI studies on orthotopic models using a radiolabeled integrin-αvβ3 ligand (99mTc-RAFT-RGD). This innovative approach presents the potential for a novel predictive imaging technique in the realm of medulloblastoma. Altogether, our findings lay the foundation for employing SPECT/MRI to identify a specific subset of patients with medulloblastoma eligible for integrin-αvβ3–directed therapies. This breakthrough offers a pathway toward more targeted and effective interventions in the treatment of medulloblastoma.

Significance:
This study demonstrates integrin-αvβ3’s fundamental role in medulloblastoma tumorigenicity and radioresistance and the effect of its expression on cilengitide functional activity.
Endovascular Recanalization for Nonacute Carotid Artery Occlusion: A Nationwide Registry‐Based Cohort Study
Authors: Hou Chao , Shi Xuan , Huo Shuxian , Yin Qin , Huang Xianjun , Sun Wen , Xiao Guodong , Yang Yong , Chen Hongbing , Li Min , Du Mingyang , Han Yunfei , Fan Xiaobing , Zhao Qingshi , Zhu Shuanggen , Liu Xinfeng , Ye Ruidong 
Published: November 2023

Background
The management of nonacute symptomatic internal carotid artery occlusion remains unsatisfactory. Endovascular recanalization has been reported to be feasible but associated with a noteworthy risk of postprocedural complications in patients with symptomatic internal carotid artery occlusion. The present study aimed to investigate whether successful recanalization exerts clinical benefits over procedural risks.

Methods
We analyzed consecutive patients who underwent endovascular treatment of nonacute symptomatic internal carotid artery occlusion in a nationwide prospective registry. The primary outcome was the ipsilateral ischemic stroke recurrence. Other outcomes of interest included all strokes and death during follow‐up, and 30‐day symptomatic intracranial hemorrhage, and all strokes after intervention.

Results

The final analysis included 511 patients. Endovascular revascularization was successful in 300 patients (58.7%) but failed in 211 patients (41.3%). Patients with successful recanalization had less time from the last ischemic event to the endovascular treatment as compared with patients with failed recanalization (median [interquartile range] days, 18 [12–33] versus 22 [14–50];
P
=0.003). Successful recanalization was associated with a higher rate of symptomatic intracranial hemorrhage within 30 days after intervention (odds ratio [OR], 7.99 [95% CI, 1.02–62.39];
P
=0.047). Thirty‐day all strokes (OR, 1.91 [95% CI, 0.83–4.40];
P
=0.128) and ischemic stroke (OR, 0.90 [95% CI, 0.33–2.46];
P
=0.839) did not differ significantly. During a median follow‐up of 37 months, patients with successful recanalization demonstrated a reduced risk of ipsilateral ischemic stroke (adjusted hazard ratio, 0.28 [95% CI, 0.13–0.59];
P
<0.001). The 5‐year risk of all strokes and death was likewise lower in patients with successful recanalization (restricted mean survival time difference, 3.77 months [95% CI, 0.16–7.38];
P
=0.041).

Conclusion
Despite an increase in the 30‐day symptomatic intracranial hemorrhage, successful recanalization was associated with reduced long‐term risk of ipsilateral ischemic stroke in patients with symptomatic internal carotid artery occlusion.
Temporal and Spatial Information Elicit Different Power and Connectivity Profiles during Working Memory Maintenance
Authors: Otstavnov Nikita , Riaz Abrar , Moiseeva Victoria , Fedele Tommaso 
Published: November 2023

Abstract
Working memory (WM) is the cognitive ability to store and manipulate information necessary for ongoing tasks. Although frontoparietal areas are involved in the retention of visually presented information, oscillatory neural activity differs for temporal and spatial WM processing. In this study, we corroborated previous findings describing the modulation of neural oscillations and expanded our investigation to the network organization underlying the cognitive processing of temporal and spatial information. We utilized MEG recordings during a Sternberg visual WM task. The spectral oscillatory activity in the maintenance phase revealed increased frontal theta (4–8 Hz) and parietal beta (13–30 Hz) in the temporal condition. Source level coherence analysis delineated the prominent role of parietal areas in all frequency bands during the maintenance of temporal information, whereas frontal and central areas showed major contributions in theta and beta ranges during the maintenance of spatial information. Our study revealed distinct spectral profiles of neural oscillations for separate cognitive subdomains of WM processing. The delineation of specific functional networks might have important implications for clinical applications, enabling the development of stimulation protocols targeting cognitive disabilities associated with WM impairments.
Young Male and Female Scientists: A Quantitative Exploratory Study of the Changing Demographics of the Global Scientific Workforce
Authors: Kwiek Marek , Szymula Lukasz 
Published: November 2023

Abstract
In this study, the global scientific workforce is explored through large-scale, generational, cross-sectional, and longitudinal approaches. We examine 4.3 million nonoccasional scientists from 38 OECD countries publishing in 1990-2021. Our interest is in the changing distribution of young male and female scientists over time across 16 STEMM (science, technology, engineering, mathematics, medicine) disciplines. We unpack the details of the changing scientific workforce using age groups. Some disciplines are already numerically dominated by women, and the change is fast in some and slow in other disciplines. In one-third of disciplines, there are already more youngest female than male scientists. Across all disciplines combined, the majority of women are young women. And more than half of women scientists (55.02%) are located in medicine. The usefulness of global bibliometric data sources in analyzing the scientific workforce along gender, age, discipline, and time is tested. Traditional aggregated data about scientists in general hide a nuanced picture of the changing gender dynamics within and across disciplines and age groups. The limitations of bibliometric datasets are explored, and global studies are compared with national-level studies. The methodological choices and their implications are shown, and new opportunities for how to study scientists globally are discussed.

Peer Review
https://www.webofscience.com/api/gateway/wos/peer-review/10.1162/qss_a_00276