bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of supplementing a Bacillus subtilis-based probiotic on performance, intestinal integrity, and serum antioxidant capacity and metabolites concentrations of heat-stressed growing pigs
Authors: González Fernanda , Cervantes Miguel , Morales Adriana , Valle José Alan , Camacho Reyna Lucero , ngélica Morales-Becerra A , Bernal Hugo , aría Mendoza Santa M , Htoo John K 
Published: January 2024

Abstract
Exposing pigs to heat stress (HS) seems to modify the intestinal microbiota which may compromise the integrity of the small intestine epithelia. Probiotics, live microorganisms, can help pigs to maintain a healthy intestinal environment. Eighty pigs (21.6 ± 3.4 kg body weight) exposed to HS or thermal neutral (TN) conditions were used to evaluate the effect of a Bacillus subtilis-based probiotic on performance, body temperature, and intestinal integrity. Treatments were: TN pigs fed a control diet without (TN-C) or with 1 × 106 CFU probiotic/g of feed (TN-P), and HS pigs fed a control without (HS-C) or with probiotic (HS-P). The control diet was formulated with wheat, soybean meal, and free amino acids (AA). Feed and water were freely available during the 21-d study. At completion, samples from duodenum, jejunum, and ileum were collected to analyze epithelial histology and tight junction protein expression; antioxidant activity, and free AA and metabolites in serum. Relative abundance of Lactobacillus, Bifidobacterium, Escherichia coli, and Bacillus in ileal content was analyzed. Ambient temperature in the TN room ranged from 19 to 25 °C, and in HS room from 30 to 38.5 °C. Intestinal temperature in HS-P pigs was lower than in HS-C pigs. Weight gain and feed intake reduced, but feed:gain and respiration rate increased in HS compared to TN pigs, regardless of diet (P &lt; 0.01). Probiotic increased weight gain and improved feed:gain (P &lt; 0.05) in both TN and HS pigs, but feed intake did not differ. Heat stress decreased villi height in jejunum and villi height:crypt depth in duodenum and jejunum (P &lt; 0.05). Probiotic increased villi height in duodenum and ileum, and villi height:crypt depth in all small intestine segments (P &lt; 0.05). Relative abundance of Lactobacillus and Bifidobacterium tended to reduce, and E. coli tended to increase (P &lt; 0.10) in ileal content of HS-C pigs. Ileal relative abundance of Bacillus was higher (P &lt; 0.01) in HS-P pigs than in HS-C and TN-C pigs. Cystathionine, homocysteine, hydroxylysine, α-amino-adipic acid, citrulline, α-amino-n-butyric acid, P-Ser, and taurine were higher in HS than in TN pigs (P &lt; 0.05). These data confirm the negative effect of HS on performance, body temperature, and intestinal integrity of pigs. These data suggest that supplementing 1 × 106 CFU probiotic/g of feed based on Bacillus subtilis DSM 32540 may help to counteract the negative effects of HS on the performance and intestinal integrity of pigs.
The Effect of Using Virtual Reality During Burn Dressing on Pain, Anxiety and Fear Felt in Children: A Randomized Controlled Trial
Authors: Kılıç Ümmühan , Tural Büyük Esra 
Published: January 2024

Abstract
This study was conducted to determine the effect of using virtual reality (VR) during burn dressing on the level of fear, anxiety, and pain that children would experience. This randomized controlled trial was conducted in a pretest-posttest design. Randomization of the participants (n = 65) was performed with the block randomization method. Then, 33 children were included in the intervention and 32 children in the control group with simple sequential randomization. The study data were collected using the “Family and Child Personal Information Form,” “Physiological Parameters Registration Form,” “Wong–Baker Faces Pain Scale,” “Children’s Fear Scale,” and “Children’s Anxiety Meter-State.” The chi-square test, t-test, Shapiro–Wilk, mean, and percentile distributions were used for the data analysis. After dressing, the physiological parameters of the children who used VR were found to be within normal limits (HR: 108.48 ± 12.43, O2: 98.39 ± 1.14) compared to the children who did not use (HR: 117.38 ± 15.25, O2: 97.81 ± 1.35) (P &lt; .05). After the dressing, children using VR (0.85 ± 1.23) were determined to have less fear than those who did not use them (3.03 ± 1.06), and similarly, children who used VR (2.64 ± 2.73) experienced less anxiety than those who did not use them (5.84 ± 2.26). When the pain levels were evaluated, the VR group (1.79 ± 2.04) was reported to feel less pain compared to the control group (5.50 ± 2.36). The VR used by children aged 5-10 years during burn dressing has been found to affect their physiological parameters and is effective in reducing fear, anxiety, and pain levels.
Inhibition of RANKL improves the skeletal phenotype of adenine-induced chronic kidney disease in mice
Authors: Metzger Corinne E , Kittaka Mizuho , LaPlant Alec N , Ueki Yasuyoshi , Allen Matthew R 
Published: January 2024

Abstract
Skeletal fragility and high fracture rates are common in CKD. A key component of bone loss in CKD with secondary hyperparathyroidism is high bone turnover and cortical bone deterioration through both cortical porosity and cortical thinning. We hypothesized that RANKL drives high bone resorption within cortical bone leading to the development of cortical porosity in CKD (study 1) and that systemic inhibition of RANKL would mitigate the skeletal phenotype of CKD (study 2). In study 1, we assessed the skeletal properties of male and female Dmp1-cre RANKLfl/fl (cKO) and control genotype (Ranklfl/fl; Con) mice after 10 wk of adenine-induced CKD (AD; 0.2% dietary adenine). All AD mice regardless of sex or genotype had elevated blood urea nitrogen and high PTH. Con AD mice in both sexes had cortical porosity and lower cortical thickness as well as high osteoclast-covered trabecular surfaces and higher bone formation rate. cKO mice had preserved cortical bone microarchitecture despite high circulating PTH as well as no CKD-induced increases in osteoclasts. In study 2, male mice with established AD CKD were either given a single injection of an anti-RANKL antibody (5 mg/kg) 8 wk post-induction of CKD or subjected to 3×/wk dosing with risedronate (1.2 μg/kg) for 4 wk. Anti-RANKL treatment significantly reduced bone formation rate as well as osteoclast surfaces at both trabecular and cortical pore surfaces; risedronate treatment had little effect on these bone parameters. In conclusion, these studies demonstrate that bone-specific RANKL is critical for the development of high bone formation/high osteoclasts and cortical bone loss in CKD with high PTH. Additionally, systemic anti-RANKL ligand therapy in established CKD may help prevent the propagation of cortical bone loss via suppression of bone turnover.
When Learning Negative Brand Associations Leads to Positive Evaluations of Effectiveness
Authors: Saint Clair Julian K , Cunha Marcus 
Published: January 2024

Abstract
Research on associative learning suggests that marketers can enhance consumer attitudes by repeatedly pairing their brands with pleasant or “positively-valenced” stimuli (e.g., attractive models, babies, cute animals) rather than unpleasant or “negatively-valenced” stimuli (e.g., garbage cans and disgusting insects)—an evaluative conditioning effect also known as affect transfer. In this research, we combine the associative learning and the goal pursuit literatures to show that the influence of affect transfer on brands depends on the mindset that is active at the time of judgment. Four experiments and one field study uniquely demonstrate that negatively-valenced brand pairings may become desirable when consumers have an instrumentality mindset, which increases attention to the instrumentality, or effectiveness, of a given consumption behavior. This pattern of results occurs due to a bidirectional association between unpleasantness and instrumentality, making a brand with negative associations seem more effective. Results are robust across contexts (health, entertainment, news) and persist regardless of whether the (un)pleasant images are within or adjacent to the advertisement. The effect attenuates when consumers have a weaker association between unpleasantness and instrumentality, and reverses when consumers are cued to focus on favorability (vs. instrumentality). Contributions and implications for associative learning and brand management are discussed.
Emergence of a multilocus mutator genotype in mutator Escherichia coli experimental populations under repeated lethal selection
Authors: Elgrail Mitra Maria , Sprouffske Kathleen , Dartey Jude O , Garcia Arlene M 
Published: January 2024

Abstract
Mutator alleles, which confer increased mutation rates, are known to spontaneously emerge and “hitchhike” to fixation in evolving asexual populations. Theory predicts that in an evolving asexual mutator population, a second mutator allele may spontaneously arise and hitchhike to fixation. Here, we describe an empirical test of the hypothesis of repeated hitchhiking. The starting population was a clonal strain of mutL−Escherichia coli whose mutation rate was 100-fold higher than wild type. We exposed the mutL− strain to a series of three antibiotics in increasing order of selective strength: fosfomycin, rifampicin, and streptomycin. Two independent replicates of the experiment were performed. As predicted, elevated mutation rates and enrichment for multilocus mutators (which bear more than one mutator allele) were observed in the end point populations of both experiments. DNA sequencing revealed an identical spontaneous 1-bp insertion in the mutator gene mutT in both end point populations. In the multilocus mutators, the causal relationship between the mutT− mutations and the increase in mutation rate was supported with mutT+ plasmid complementation tests. Surprisingly, when the experiment was repeated with the antibiotics deployed in decreasing order of selective strength, enrichment for multilocus mutators was not observed. Our data support the likelihood that the mutT− mutations rose to fixation in both populations, consistent with the hypothesis of repeated mutator hitchhiking. The escalation of mutation rates in asexual populations is relevant to multiple biological scenarios, including antibiotic resistance, host–pathogen interactions, and carcinogenesis.
Infants Receiving a Single Dose of Nirsevimab to Prevent RSV Do Not Have Evidence of Enhanced Disease in Their Second RSV Season
Authors: Dagan Ron , Hammitt Laura L , Seoane Nuñez Beatriz , Baca Cots Manuel , Bosheva Miroslava , Madhi Shabir A , Muller William J , Zar Heather J , Chang Yue , Currie Alexander , Grenham Amy , Shroff Manish , Takas Therese , Mankad Vaishali S , Leach Amanda , Villafana Tonya 
Published: January 2024

Abstract
To characterize nirsevimab in the prevention of RSV, children from the Phase 3 MELODY trial were followed through their second RSV season. No increase in medically attended RSV lower respiratory tract infections or evidence of antibody-dependent enhancement of infection or disease severity was found for nirsevimab vs placebo recipients.
Clinical Trial Registration: Clinicaltrials.gov, NCT03979313, https://clinicaltrials.gov/ct2/show/NCT03979313.
NuSTAR and Swift observations of two supergiant fast X-ray transients: AX J1841.0−0536 and SAX J1818.6−1703
Authors: Bozzo E , Ferrigno C , Romano P 
Published: January 2024

ABSTRACT
Supergiant fast X-ray transients are wind-fed binaries hosting neutron star accretors, which display a peculiar variability in the X-ray domain. Different models have been proposed to explain this variability and the strength of the compact object magnetic field is generally considered a key parameter to discriminate among possible scenarios. We present here the analysis of two simultaneous observational campaigns carried out with Swift and NuSTAR targeting the supergiant fast X-ray transient sources AX J1841.0−0536 and SAX J1818.6−1703. A detailed spectral analysis is presented for both sources, with the main goal of hunting for cyclotron resonant scattering features that can provide a direct measurement of the neutron star magnetic field intensity. AX J1841.0−0536 was caught during the observational campaign at a relatively low flux. The source broad-band spectrum was featureless and could be well-described by using a combination of a hot blackbody and a power-law component with no measurable cut-off energy. In the case of SAX J1818.6−1703, the broad-band spectrum presented a relatively complex curvature which could be described by an absorbed cut-off power law (including both a cut-off and a folding energy) and featured a prominent edge at ∼7 keV, compatible with being associated to the presence of a ‘screen’ of neutral material partly obscuring the X-ray source. The fit to the broad-band spectrum also required the addition of a moderately broad (∼1.6 keV) feature centred at ∼14 keV. If interpreted as a cyclotron resonant scattering feature, our results would indicate for SAX J1818.6−1703 a relatively low-magnetized neutron star (∼1.2 × 1012 G).
New candidate hypervelocity red clump stars in the inner Galactic bulge
Authors: Luna A , Marchetti T , Rejkuba M , Leigh N W C , Alonso-García J , Valenzuela Navarro A , Minniti D , Smith L C 
Published: January 2024

ABSTRACT
We search for high-velocity stars in the inner region of the Galactic bulge using a selected sample of red clump stars. Some of those stars might be considered hypervelocity stars (HVSs). Even though the HVSs ejection relies on an interaction with the supermassive black hole (SMBH) at the centre of the Galaxy, there are no confirmed detections of HVSs in the inner region of our Galaxy. With the detection of HVSs, ejection mechanism models can be constrained by exploring the stellar dynamics in the Galactic centre through a recent stellar interaction with the SMBH. Based on a previously developed methodology by our group, we searched with a sample of preliminary data from version 2 of the Vista Variables in the Via Lactea (VVV) Infrared Astrometric Catalogue (VIRAC2) and Gaia DR3 data, including accurate optical and near-infrared proper motions. This search resulted in a sample of 46 stars with transverse velocities larger than the local escape velocity within the Galactic bulge, of which four are prime candidate HVSs with high-proper motions consistent with being ejections from the Galactic centre. Adding to that, we studied a sample of reddened stars without a Gaia DR3 counterpart and found 481 stars with transverse velocities larger than the local escape velocity, from which 65 stars have proper motions pointing out of the Galactic centre and are candidate HVSs. In total, we found 69 candidate HVSs pointing away from the Galactic centre with transverse velocities larger than the local escape velocity.
Persistent gravitational radiation from glitching pulsars – II. Updated scaling with vortex number
Authors: Cheunchitra T , Melatos A , Carlin J B , Howitt G 
Published: January 2024

ABSTRACT
Superfluid vortices pinned to nuclear lattice sites or magnetic flux tubes in a neutron star evolve abruptly through a sequence of metastable spatial configurations, punctuated by unpinning avalanches associated with rotational glitches, as the stellar crust spins down electromagnetically. The metastable configurations are approximately but not exactly axisymmetric, causing the emission of persistent, quasimonochromatic, current quadrupole gravitational radiation. The characteristic gravitational wave strain h0 as a function of the spin frequency f and distance D from the Earth is bounded above by $h_0 = 1.2\substack{+1.3 \\ -0.9} \times 10^{-32} (f/30\,\,{\rm Hz})^{2.5} (D/1\,\,{\rm kpc})^{-1}$, corresponding to a Poissonian spatial configuration (equal probability per unit area, i.e. zero inter-vortex repulsion), and bounded below by $h_0 = 1.8\substack{+2.0 \\ -1.5} \times 10^{-50} (f/30\,\,{\rm Hz})^{1.5} (D/1\,\,{\rm kpc})^{-1}$, corresponding to a regular array (periodic separation, i.e. maximum inter-vortex repulsion). N-body point vortex simulations predict an intermediate scaling, $h_0 = 7.3\substack{+7.9 \\ -5.4} \times 10^{-42} (f/30\,\,{\rm Hz})^{1.9} (D/1\,\,{\rm kpc})^{-1}$, which reflects a balance between the randomizing but spatially correlated action of superfluid vortex avalanches and the regularizing action of inter-vortex repulsion. The scaling is calibrated by conducting simulations with Nv ≤ 5 × 103 vortices and extrapolated to the astrophysical regime Nv ∼ 1017(f/30 Hz). The scaling is provisional, pending future computational advances to raise Nv and include three-dimensional effects such as vortex tension and turbulence.
The impact of the FREDDA dedispersion algorithm on H0 estimations with fast radio bursts
Authors: Hoffmann J , James C W , Qiu H , Glowacki M , Bannister K W , Gupta V , Prochaska J X , Bera A , Deller A T , Gourdji K , Marnoch L , Ryder S D , Scott D R , Shannon R M , Tejos N 
Published: January 2024

ABSTRACT
Fast radio bursts (FRBs) are transient radio signals of extragalactic origins that are subjected to propagation effects such as dispersion and scattering. It follows then that these signals hold information regarding the medium they have traversed and are hence useful as cosmological probes of the Universe. Recently, FRBs were used to make an independent measure of the Hubble constant H0, promising to resolve the Hubble tension given a sufficient number of detected FRBs. Such cosmological studies are dependent on FRB population statistics, cosmological parameters, and detection biases, and thus it is important to accurately characterize each of these. In this work, we empirically characterize the sensitivity of the Fast Real-time Engine for Dedispersing Amplitudes (FREDDA) which is the current detection system for the Australian Square Kilometre Array Pathfinder (ASKAP). We coherently redisperse high-time resolution data of 13 ASKAP-detected FRBs and inject them into FREDDA to determine the recovered signal-to-noise ratios as a function of dispersion measure. We find that for 11 of the 13 FRBs, these results are consistent with injecting idealized pulses. Approximating this sensitivity function with theoretical predictions results in a systematic error of 0.3 km s−1 Mpc−1 on H0 when it is the only free parameter. Allowing additional parameters to vary could increase this systematic by up to $\sim 1\,$ km s−1 Mpc−1. We estimate that this systematic will not be relevant until ∼400 localized FRBs have been detected, but will likely be significant in resolving the Hubble tension.
Free-floating ‘planets’ in the macrolensed quasar Q2237+0305
Authors: Tuntsov Artem V , Lewis Geraint F , Walker Mark A 
Published: January 2024

ABSTRACT
It has been claimed that the variability of field quasars resembles gravitational lensing by a large cosmological population of free-floating planets with mass $\sim\!\! 10\ {\rm M}_{\oplus }$. However, Galactic photometric monitoring experiments, on the other hand, exclude a large population of such planetary-mass gravitational lenses. These apparently contradictory pieces of evidence can be reconciled if the objects under consideration have a mean column density that lies between the critical column densities for gravitational lensing in these two contexts. Dark matter in that form is known to be weakly collisional, so a core develops in galaxy halo density profiles, and a preferred model has already been established. Here, we consider what such a model implies for Q2237+0305, which is the best-studied example of a quasar that is strongly lensed by an intervening galaxy. We construct microlensing magnification maps appropriate to the four macro-images of the quasar – all of which are seen through the bulge of the galaxy. Each of these maps exhibits a caustic network arising from the stars, plus many small, isolated caustics arising from the free-floating ‘planets’ in the lens galaxy. The ‘planets’ have little influence on the magnification histograms but a large effect on the statistics of the magnification gradients. We compare our predictions to the published Optical Gravitational Lensing Experiment (OGLE) photometry of Q2237+0305 and find that these data are consistent with the presence of the hypothetical ‘planets’. However, the evidence is relatively weak because the OGLE data set is not well suited to testing our predictions and requires low-pass filtering for this application. New data from a large, space-based telescope are desirable to address this issue.
A 3D diffusive and advective model of electron transport applied to the pulsar wind nebula HESS J1825 − 137
Authors: Collins T , Rowell G , Einecke S , Voisin F , Fukui Y , Sano H 
Published: January 2024

ABSTRACT
HESS J1825 − 137 is one of the most powerful and luminous TeV gamma-ray pulsar wind nebulae, making it an excellent laboratory to study particle transportation around pulsars. We present a model of the (diffusive and advective) transport and radiative losses of electrons from the pulsar PSR J1826 − 1334 powering HESS J1825 − 137 using interstellar medium gas (ISM) data, soft photon fields, and a spatially varying magnetic field. We find that for the characteristic age of $21\, \mathrm{k}\mathrm{yr}$, PSR J1826 − 1334 is unable to meet the energy requirements to match the observed X-ray and gamma-ray emission. An older age of $40\, \mathrm{k}\mathrm{yr}$, together with an electron conversion efficiency of 0.14 and advective flow of v = 0.002c, can reproduce the observed multiwavelength emission towards HESS J1825 − 137. A turbulent ISM with magnetic field of $B=20 \,{\rm to}\, 60 \,\mathrm{\mu }{\rm G}$ to the north of HESS J1825 − 137 (as suggested by ISM observations) is required to prevent significant gamma-ray contamination towards the northern $\mathrm{T}\mathrm{e\mathrm{V}}$ source HESS J1826 − 130.
Constraints on cosmologically coupled black holes from gravitational wave observations and minimal formation mass
Authors: Amendola Luca , Rodrigues Davi C , Kumar Sumit , Quartin Miguel 
Published: January 2024

ABSTRACT
We test the possibility that the black holes (BHs) detected by LIGO-Virgo-KAGRA (LVK) may be cosmologically coupled and grow in mass proportionally to the cosmological scale factor to some power k, which may also act as the dark energy source if k ≈ 3. This approach was proposed as an extension of Kerr BHs embedded in cosmological backgrounds and possibly without singularities or horizons. In our analysis, we develop and apply two methods to test these cosmologically coupled BHs (CCBHs) either with or without connection to dark energy. We consider different scenarios for the time between the binary BH formation and its merger, and we find that the standard log-uniform distribution yields weaker constraints than the CCBH-corrected case. Assuming that the minimum mass of a BH with stellar progenitor is 2 M⊙, we estimate the probability that at least one BH among the observed ones had an initial mass below this threshold. We obtain these probabilities either directly from the observed data or by assuming the LVK power-law-plus-peak mass distribution. In the latter case, we find at 2σ level, that k &lt; 2.1 for the standard log-uniform distribution, or k &lt; 1.1 for the CCBH-corrected distribution. Slightly weaker bounds are obtained in the direct method. Considering the uncertainties on the nature of CCBHs, we also find that the required minimum CCBH mass value to eliminate the tensions for k = 3 should be lower than 0.5 M⊙ (again at 2σ). Finally, we show that future observations have the potential to decisively confirm these bounds.