bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postmortem CT analysis of paranasal sinuses using an experimental model of drowning
Authors: Tyr Alexander , Zilg Brita , Gelius Tobias , Möllby Rasmus , Heldring Nina 
Published: February 2024

AbstractFluid-filled paranasal sinuses are suggested to be a valuable tool to distinguish between drowning and non-drowning postmortem, yet the mechanisms governing fluid entry remains unknown. We investigate if fluid-filled paranasal sinuses are caused by a passive influx from submersion or an active aspiration mechanism during drowning. The ovine nasal cavity and maxillary sinuses are remarkably similar anatomically to humans, and have been used for endoscopic surgical training in recent decades. We submerged 15 decapitated ovine heads from agricultural waste at a depth of 2 m in flowing water for 1, 8, and 24 h and 7 days. Paranasal sinuses were CT imaged and compared pre- and post-submersion to non-submerged controls. Furthermore, we examined the paranasal sinuses of a single homicide case of a non-drowned submerged subject. Results demonstrate that fluid passively enters the maxillary sinus postmortem in the non-drowned ovine heads following 1 h of submersion. Fluid volume was independent of submersion time and influenced by time out of water as well as handling, since volume was reduced between consecutive CT scans. In contrast to our hypothesis, the filling of the paranasal sinuses is due to passive influx of fluid from submersion rather than an active aspiration during drowning. The observation that paranasal sinuses were fluid-filled in a single medico-legal case of postmortem submersion supports the finding of passive influx. Consequently, careful interpretation of fluid-filled paranasal sinuses is required when bodies are found in water, as the finding cannot distinguish between postmortem submersion and drowning.
The effect of gastrostomy tube feeding on growth in children with chronic kidney disease and on dialysis
Authors: Alshaiban Abdulelah , Osuntoki Adebola , Cleghorn Shelley , Loizou Antonia , Shroff Rukshana 
Published: February 2024

Abstract
Background
Gastrostomy tube (GT) feeding is used to promote nutrition and growth in children with chronic kidney disease (CKD). We explored the relationship between gastrostomy feeding and growth parameters in children with CKD, looking specifically at the nutritional composition of feeds.

Methods
Children with CKD stages 3–5 or on dialysis in a tertiary children’s kidney unit were studied. Data on anthropometry, biochemistry, and nutritional composition of feeds were collected from the time of GT insertion for 3 years or until transplantation.

Results
Forty children (18 female) were included. Nineteen children were on peritoneal dialysis, 8 on hemodialysis, and 13 had CKD stages 3–5. The median (interquartile range [IQR]) age at GT insertion was 1.26 (0.61–3.58) years, with 31 (77.5%) under 5 years of age. The median duration of gastrostomy feeding was 5.32 (3.05–6.31) years. None received growth hormone treatment. Children showed a significant increase in weight standard deviation score (SDS) (p = 0.0005), weight-for-height SDS (p = 0.0007) and body mass index (BMI) SDS (p < 0.0001). None of the children developed obesity. Although not statistically significant, the median height-SDS increased into the normal range (from -2.29 to -1.85). Weight-SDS positively correlated with the percentage of energy requirements from feeds (p = 0.02), and the BMI-SDS correlated with the percentage of total energy intake as fat (p < 0.001).

Conclusion
GT feeding improves weight-SDS and BMI-SDS without leading to obesity. GT feeding improved height-SDS but this did not reach statistical significance, suggesting that factors in addition to nutritional optimization need to be considered for statural growth.

Graphical abstract
Enhancing age-related postural sway classification using partial least squares-discriminant analysis and hybrid feature set
Authors: Alcan Veysel 
Published: February 2024

AbstractFeature sets in a machine learning algorithm can have an impact on the robustness, interpretability, and characterization of the data. To detect age-related changes, traditional linear methods for analyzing center of pressure (COP) signals offer limited insight into the complex nonlinear dynamics of postural control. To overcome this limitation, a novel approach that combines a partial least squares-discriminant analysis (PLS-DA) classifier with the nonlinear dynamics of COP time series was proposed. Three small feature sets were compared: time-domain features alone, entropy-based features alone, and a hybrid approach incorporating both types of features. The performance of the PLS-DA model was assessed in four different eyes and surface conditions by using the accuracy, sensitivity, selectivity, precision metrics, and ROC curves. The results indicated that the PLS-DA model utilizing the hybrid feature set achieved significantly higher accuracy than the time-domain and entropy-based feature sets. The best classification performance was observed when the eyes were open on a compliant surface, with an overall accuracy of 89% for training and 88% for cross-validation. For the old group, while the results indicated 93% sensitivity, 94% specificity, and 93% precision in the training, the results revealed 88% sensitivity, 93% specificity, and 91% precision in cross-validation. Notably, the hybrid feature set yielded an AUC value of 0.96, indicating a superior performance. This study emphasizes the robust classification capabilities of PLS-DA for age-related postural changes and highlights the effectiveness of utilizing a small hybrid feature set to improve classification accuracy and reliability.
Biaxial flexural strength of 3D-printed 3Y-TZP zirconia using a novel ceramic printer
Authors: Zenthöfer Andreas , Ilani Ali , Schmitt Clemens , Rammelsberg Peter , Hetzler Sebastian , Rues Stefan 
Published: February 2024

Abstract
Objectives
To compare the strength and reliability of 3D-printed 3Y-TZP zirconia manufactured with various printing orientations and staining.

Materials and methods
A total of one-hundred cylindrical zirconia specimens were designed and fabricated using 3D printing and processed according to ISO 6872 standards. Of these specimens, 80 were 3D printed using the new ZIPRO-D (ZD) 3D ceramic printer. In this ZD group, 60 specimens were printed in a vertical orientation and were either stained after debinding (ZD1, x-orientation, n = 20) or not stained (ZD2, x-orientation, n = 20; ZD3, y-orientation, n = 20) and the remaining 20 specimens out of n = 80 were printed in a horizontal orientation (ZD4). Further 20 specimens out of the entire sample N = 100 were printed vertically with the CeraFab7500 3D ceramic printer (LC). All completed specimens were loaded until fracture using a universal testing machine. Biaxial flexural strengths and Weibull parameters were computed for the ZD groups and for the LC group. Group and sub-group effects were evaluated using Welch ANOVA (alpha = 0.05).

Results
The mean (standard deviation, SD) biaxial flexural strengths of vertically oriented ZD samples with (ZD1) and without (ZD2/ZD3) staining were 811 (197) and 850 (152) MPa, respectively (p > 0.05). The ZD4 (horizontally printed), 1107 (144) MPa, and LC (1238 (327)) MPa samples had higher mean (SD) flexural strengths than the ZD1–3 specimens. No difference was observed between the ZD4 and LC group (p > 0.05). Weibull moduli were between m = 4.6 (ZD1) and 9.1 (ZD4) in the ZD group and m = 3.5 in the LC group.

Conclusions
All tested 3D-printed zirconia specimens exceeded the flexural strengths required for class 5 restorations according to ISO 6872 standards. While the flexural strengths of zirconia printed using the novel ZD device in the vertical orientation are lower than those of zirconia printed using the LC printer, the ZD printer shows at least comparable reliability.

Clinical relevance
3D-printing of zirconia is a new technology in dental application. Based on the presented strengths values, clinical application of 3D-printed zirconia for fixed dental protheses can be recommended.
Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension
Authors: Zhou Jie , Guo Dan , Xu Zhen-Zhen , Liao Jia-Shun , Li Xiao-Ting , Duan Ke , Chen Shi-You , Xie Wei-Bing 
Published: February 2024

Abstract
Aims
Nuclear protein 1 (Nupr1) is a multifunctional stress-induced protein involved in the regulation of tumorigenesis, apoptosis, and autophagy. However, its role in pulmonary hypertension (PH) after METH exposure remains unexplored. In this study, we aimed to investigate whether METH can induce PH and describe the role and mechanism of Nupr1 in the development of PH.

Methods and results
Mice were made to induce pulmonary hypertension (PH) upon chronic intermittent treatment with METH. Their right ventricular systolic pressure (RVSP) was measured to assess pulmonary artery pressure. Pulmonary artery morphometry was determined by H&E staining and Masson staining. Nupr1 expression and function were detected in human lungs, mice lungs exposed to METH, and cultured pulmonary arterial smooth muscle cells (PASMCs) with METH treatment. Our results showed that chronic intermittent METH treatment successfully induced PH in mice. Nupr1 expression was increased in the cultured PASMCs, pulmonary arterial media from METH-exposed mice, and METH-ingested human specimens compared with control. Elevated Nupr1 expression promoted PASMC phenotype change from contractile to synthetic, which triggered pulmonary artery remodeling and resulted in PH formation. Mechanistically, Nupr1 mediated the opening of store-operated calcium entry (SOCE) by activating the expression of STIM1, thereby promoting Ca2+ influx and inducing phenotypic conversion of PASMCs.

Conclusions
Nupr1 activation could promote Ca2+ influx through STIM1-mediated SOCE opening, which promoted METH-induced pulmonary artery remodeling and led to PH formation. These results suggested that Nupr1 played an important role in METH-induced PH and might be a potential target for METH-related PH therapy.

Graphical Abstract

1. Chronic intermittent methamphetamine exposure can induce the development of pulmonary arterial hypertension.
2. Nupr1 plays a key role in the development of methamphetamine-related pulmonary arterial hypertension.
3. Nupr1 mediates PASMCs phenotypic transformation via STIM1signal axis, which results in the development of methamphetamine-related pulmonary arterial hypertension.
Frequency and Focus of in Vitro Studies of Microglia-Expressed Cytokines in Response to Viral Infection: A Systematic Review
Authors: Barrios-González Diego A. , Philibert-Rosas Santiago , Martínez-Juárez Iris E. , Sotelo-Díaz Fernando , Rivas-Alonso Verónica , Sotelo Julio , Sebastián-Díaz Mario A. 
Published: February 2024

AbstractIt is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescent state to an activated state that includes proinflammatory and anti-inflammatory phases; this behavior has been described through in vitro studies. However, recent in vivo studies on the function of microglia have questioned the two-phase paradigm; therefore, a change in the frequency of in vitro studies is expected. A systematic review was carried out to identify the microglial cytokine profile against viral infection that has been further evaluated through in vitro studies (pro-inflammatory or anti-inflammatory), along with analysis of its publication frequency over the years. For this review, 531 articles published in the English language were collected from PubMed, Web of Science, EBSCO and ResearchGate. Only 27 papers met the inclusion criteria for this systematic review. In total, 19 cytokines were evaluated in these studies, most of which are proinflammatory; the most common are IL-6, followed by TNF-α and IL-1β. It should be pointed out that half of the studies were published between 2015 and 2022 (raw data available in https://github.com/dadriba05/SystematicReview.git). In this review, we identified that evaluation of pro-inflammatory cytokines released by microglia against viral infections has been performed more frequently than that of anti-inflammatory cytokines; additionally, a higher frequency of evaluation of the response of microglia cells to viral infection through in vitro studies from 2015 and beyond was noted.
Graphical Abstract
In vitro assessment of microglia-released cytokines upon viral infection has been more frequent since 2015 and has focused more on pro-inflammatory cytokines.
Analysis, evaluation and implications of Rhode Island’s “2021 Act on Climate” for response to climate change
Authors: Kim Doosu , Park Tae Jung 
Published: February 2024

AbstractThe state of Rhode Island is responding appropriately to the climate crisis by enacting “the Resilient Rhode Island Act of 2014” and then preparing the revised “2021 Act on Climate.” Accordingly, Rhode Island strives to achieve carbon neutrality in 2050 by establishing and evaluating a climate change response plan and setting science-based climate goals through the Executive Climate Change Coordinating Council through consultation with the Advisory Board and the Science and Technical Advisory Board. Additionally, Rhode Island is committed to establishing industry support strategies to respond to climate change, considering future generations, including children, in the impacts of climate change, utilizing the knowledge of private experts at universities, and promoting public education on climate change response. However, matters that need to be supplemented and improved in the implementation of Rhode Island’s climate change-related legal policies include the fair and transparent selection of advisors from an organizational perspective and the securing of dedicated personnel and budget for practical work.
From Tendencies and Drives to Affectivity and Ethics: Husserl and Scheler on the Mother–Child Relationship
Authors: Serban Claudia 
Published: February 2024

AbstractThe reassessment of intentionality as “tendency” or “drive,” already important when the intentionality at stake designates the directedness of lived experiences toward a particular object, might be even more crucial when the orientation toward others is concerned. How do drives and affects intermingle within our intersubjective life and fashion our relations to others? The present paper will address this question by focusing on a particular or even primary kind of intersubjectivity: the mother–child relationship, that received a particular, yet still insufficiently noticed attention in early phenomenology. Scheler and Husserl both analyse this relationship, indeed, in terms that imply drive intentionality as well as affective intentionality (that is, for what concerns the mother, maternal instinct and maternal love). In their view, this relation also has a crucial ethical significance, and may even be taken to be paradigmatic for ethical relationships as such. Accordingly, drive intentionality is understood as an instinctive orientation toward others, that love takes up and develops, thus providing an affective and even instinctive ground for ethical behaviour. All this imples the depart from an ethics grounded on the primacy and sufficiency of reason.
The Role of Anions in Rare-earth Activated Inorganic Host Materials for its Luminescence Characteristics
Authors: Reddy Leelakrishna 
Published: February 2024

AbstractThis work is inspired from the comprehensive work done by our research team aimed at improving the efficiency of white light emitting diodes (LEDs) through improvements in the colour rendering index of the red light (CRI), one of the primary colours of white light. Such work is triggered through the incorporation of anions (BO33−, PO43−, SO42−), either individually or as an integral part of dopant activated inorganic phosphor host materials. Numerous host materials such as ZnO, Y2O3, Ca3(PO4)2, CaMoO4, ABPO4, ABSO4 (where A represents alkali metals and B alkaline earth metals) have been considered ideal hosts materials for studying luminescence properties of materials (including other phosphors). In addition, red emitting dopants such as Sm3+, Eu3+ and Ce3+ have been incorporated into these host materials to achieve a higher CRI of red colour, an essential component of white light. The role anions in various materials is multifaceted; firstly, it acts as sensitizer whereby it absorbs excitation energy and transfers it non-radiatively to the dopants, secondly, it acts as a charge compensator to dopants with a charge of + 3, thirdly, it creates crystal fields that affects the electronic transitions of the dopants and fourthly, it creates a stable crystal structure that allows for dopant embedding. By understanding the exact role of these anions and their interactions with the host lattice and dopant ions, we could further optimize the luminescent properties of these activated host materials, which leads to higher efficiencies and performances in white light-emitting diodes and other lighting technologies. This work is a comprehensive review of the work undertaken by our research team aimed at enhancing the luminescent properties of WLEDs.
Role of Positive and Negative Emotion Regulation in Well-being and Health: The Interplay between Positive and Negative Emotion Regulation Abilities is Linked to Mental and Physical Health
Authors: Tsujimoto Masayuki , Saito Toshiki , Matsuzaki Yutaka , Kawashima Ryuta 
Published: February 2024

AbstractAppropriate regulation of emotions is vital to daily functioning. Previous studies have shown that regulating negative emotions can improve health and wellbeing. However, the relationship between positive and negative emotion regulation and their interactions with positive and negative affect, life satisfaction, and health is not well understood. In addition, no studies have investigated the role of attention control and trait mindfulness in positive and negative emotion regulation. This study examined the associations between positive and negative emotion regulation abilities and health, affect, life satisfaction, attention control, and trait mindfulness. A total of 490 participants (284 females and 206 males, mean age = 25.8 ± 2.9 years, range = 20–29 years) completed questionnaires and attention measuring tasks. Multiple regression analyses revealed that negative emotion regulation ability was associated with affect, life satisfaction, and health, whereas positive emotion regulation ability was related to negative affect and mental and physical health. Additionally, negative rather than positive emotion regulation ability was more strongly associated with trait mindfulness and attention control. Positive emotion regulation may benefit those who have difficulty in regulating negative emotions. By focusing on both negative and positive emotion regulation, this study elucidates the relationship between emotion regulation ability, positive and negative affect, life satisfaction, health, mindfulness, and attention control.
Sampling and Change of Measure for Monte Carlo Integration on Simplices
Authors: Song Chenxiao , Kawai Reiichiro 
Published: February 2024

AbstractSimplices are the fundamental domain when integrating over convex polytopes. The aim of this work is to establish a novel framework of Monte Carlo integration over simplices, throughout from sampling to variance reduction. Namely, we develop a uniform sampling method on the standard simplex consisting of two independent procedures and construct theories on change of measure on each of the two independent elements in the developed sampling technique with a view towards variance reduction by importance sampling. We provide illustrative figures and numerical results to support our theoretical findings and demonstrate the strong potential of the developed framework for effective implementation and acceleration of Monte Carlo integration over simplices.
How seasonality, semi-natural habitat cover and compositional landscape heterogeneity affect pollen collection and development of Apis mellifera colonies in Mediterranean agro-sylvo-pastoral systems
Authors: Satta Alberto , Lezzeri Matteo , Brundu Giuseppe , Floris Ignazio , Palmieri Nicola , Pantaleoni Roberto Antonio , Theodorou Panagiotis , Pusceddu Michelina 
Published: February 2024

Abstract
Context
The reduction in the abundance and diversity of flowering plant species, mainly due to landscape alteration and consequent habitat loss, negatively affects honey bee populations and is the main driver of their decline. To safeguard pollination service and food security, we need to know how landscape characteristics affect the availability of pollen sources and consequently colony performance across seasons.

Objectives
We therefore here explore how seasonality, percentage of semi-natural habitat cover and compositional landscape heterogeneity affect the abundance, richness, diversity and composition of pollen collected by honey bees and the development of their colonies in a Mediterranean area where agro-sylvo-pastoral systems are widely spread.

Methods
For the purpose of our study, pollen samples were collected over a year from colonies of Apis mellifera placed in four sampling sites selected across a gradient of landscape heterogeneity and where semi-natural habitats were predominant at various levels within an agro-sylvo-pastoral zone. Simultaneously, the extension of the sealed brood of the same colonies was periodically evaluated.

Results
We found that the amount of pollen collected by honey bees was positively correlated with the percentage of semi-natural habitat cover and that increasing habitat diversity at the landscape level had a significant positive effect on the richness and diversity of pollen collected by honey bees. In addition, season significantly affected the amount, diversity and composition of pollen collected by honey bees. Furthermore, bee colony growth was positively correlated with richness, diversity and amount of pollen collected by honey bees.

Conclusion
Our study highlights the importance of an abundant and diverse pollen diet for honey bee colony development, which in agro-sylvo-pastoral systems seems to be ensured by a heterogeneous landscape dominated by different types of semi-natural habitats.
On the set of reduced states of translation invariant, infinite quantum systems
Authors: Blakaj Vjosa , Wolf Michael M. 
Published: February 2024

AbstractThe set of two-body reduced states of translation invariant, infinite quantum spin chains can be approximated from inside and outside using matrix product states and marginals of finite systems, respectively. These lead to hierarchies of algebraic approximations that become tight only in the limit of infinitely many auxiliary variables. We show that this is necessarily so for any algebraic ansatz by proving that the set of reduced states is not semialgebraic. We also provide evidence that additional elementary transcendental functions cannot lead to a finitary description.