bluuebunny/crossref_metadata_2025_split huggingface dataset:
Providing trusted COVID-19 sources in social media: Establishing Indonesian Pediatric Society's social media ecosystem
Authors: Sjakti Hikari Ambara , Sambo Catharine Mayung , Mardhani Tiara Annisa P. , Ruslim Saskia Octariza , Atmaja Clara Petrisiela I. , Yanuarso Piprim Basarah , Pulungan Aman Bhakti 
Published: January 2024

Introduction:
During the COVID-19 pandemic, social media has become the main platform to find information in every aspect. It is important for professional organizations to develop social media in their field. The Indonesian Pediatric Society (IPS) has distributed information through various social media channels, like Professional Official Website. It is formed to reach various target users, hoping that information will be spread evenly among all Indonesian parents. This study aims to describe how the IPS media ecosystem provides trusted health information, which can help disseminate health information among parents and health practitioners during the pandemic.

Methods:
The study used a descriptive design using IPS social media platforms such as Professional Official Website (idai.or.id), Instagram, Facebook, Twitter, YouTube, Public Official Website (anakindonesiasehat.com), and Telemedicine Mobile Application (PrimaKu).

Results:
The IPS's social media accounts have shown significant growth during the pandemic showing that people are more aggressively seeking information from trusted sources. A public education-related Instagram live footage titled “Drugs and Vitamins for children with COVID-19 during quarantine at home” has become the most demanded material for social media users. This shows that social media is an excellent platform for health promotion.

Conclusion:
IPS, as a professional organization, needs to provide accurate, reliable, and up-to-date information on its social media and should take advantage of this opportunity to disseminate the latest guidelines and educate the public more thoroughly, especially parents, to help them obtain information on children's health.
The freshmen’s attitudes towards using videos in reading class
Authors: Phuong Tran Thanh , Quynh Ngo Nhat Phuong 
Published: January 2024

Implementing video clips on enhancing university students’
reading skill have been popular in Vietnam. This study aimed at
exploring the effects of employing video clips in reading
improvement of English-majored freshmen from their perspectives.
What is crucial here is whether applying video clips to teaching and
can boost the learners’ reading performance or not as well as how
profound their upgrade in reading is. For this study, the quantitative
approach as well as accumulating data were applied to investigate
the students’ perceptions regarding the cons occurred when applying
video clips to the development of their reading skill. To collect data
for the study, fifty first-year English majors took part in the online
questionnaire regarding the reading performance after reading
period by video clip assistance. The findings reflect that the majority
of the students had a positive attitude towards utilizing videos in
acquiring the reading skill. As a result, with the implementation of
videos in reading classes, students were motivated to engage in
reading activities. Additionally, teachers are encouraged to make use
of the online video sources to increase the students’ motivation and
engagement in acquiring reading skill.
Extramural English and Vietnamese EFL primary school students’ listening and reading proficiency in Vietnam
Authors: Thi Dang Thi , Thinh Le Van 
Published: January 2024

Many studies worldwide have found correlations between
students’ exposure to English outside the classroom and students’
English vocabulary and oral proficiency. However, these studies
have mostly been conducted with ESL (English as a Second
Language) high school students or older students, while primary
school students in EFL (English as a Foreign Language) countries
have not been well documented. The study aimed to (1) investigate
whether there are any correlations between Extramural English (EE)
and listening and reading proficiency of Vietnamese EFL primary
school students, and (2) determine their experience with EE. The
participants were 101 Vietnamese elementary school students. Both
interviews and questionnaires were used to collect information
regarding students’ extramural English outside of the classroom and
their experiences in EE activities. An English proficiency test
including listening and reading was employed to examine students’
listening and reading. Findings showed that there was a correlation
between extramural English and EFL primary students’ listening and
reading proficiency. Most students participated in two main EE
activities: using English game-based learning applications and
surfing the internet. The study suggested different techniques, some
online games, and materials to support learners in acquiring a new
language actively, and teachers could encourage more students to
practice extramural English outside the classroom.
Quantitative stability estimate for the inverse coefficients problem in linear elasticity
Authors: Meftahi H , Rezgui T 
Published: January 2024

In this article we consider the inverse problem of reconstructing piece-wise Lamé coefficients from boundary measurements. We reformulate the inverse problem into a minimization one using a Kohn-Vogelius type functional. We study the stability of the parameters when the jump of the discontinuity is perturbed. Using tools of shape calculus, we give a quantitative stability result for local optimal solution.
Dans cet article, nous considérons le problème inverse de reconstruction des coefficients de Lamé constants par morceaux à partir de mesures au bord. Nous reformulons le problème inverse en un problème de minimisation utilisant une fonctionnelle de type Kohn-Vogelius. Nous étudions la stabilité des paramètres lorsque le saut de la discontinuité est perturbé. En utilisant les outils du calcul de forme, nous donnons un résultat de stabilité quantitative pour une la solution optimale locale.
INOVASI PENDIDIKAN DI BIDANG MANAJEMEN KELAS DALAM PEMBELAJARAN DARING UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA SEKOLAH DASAR
Authors: Riadi Fadhilah Salsabila , Rostika Deti 
Published: January 2024

Abstract: The purpose of this study is to examine educational innovations in the field of classroom management in online learning to increase the learning motivation of elementary school students. This research was conducted using qualitative research methods. With research techniques literature studies from various relevant sources. The result of this research is that increasing students' motivation in online learning, it can be done through classroom management to create effective classroom conditions. By applying the principles of classroom management, managing the classroom environment, creating a positive atmosphere in the classroom, applying rules, and establishing good communication with the teacher as a facilitator. The existence of classroom management in achieving effective learning can increase student learning motivation and make learning more focused. In addition, the contribution of parents is also needed in guiding and assisting students during online learning carried out from home.Keywords: classroom management innovation, online learning, learning motivation, elementary school Abstrak: Maka dari itu tujuan penelitian ini mengkaji perihal inovasi pendidikan di bidang manajemen kelas dalam pembelajaran daring untuk meningkatkan motivasi belajar siswa sekolah dasar. Penelitian ini dilakukan dengan menggunakan metode penelitian kualitatif. Dengan teknik penelitian studi literatur dari berbagai sumber yang relevan. Hasil dari penelitian ini yaitu dalam meningkatkan motivasi belajar siswa dalam pembelajaran daring dapat dilakukan melalui manajemen kelas agar tercipta kondisi kelas yang efektif. Dengan menerapkan prinsip-prinsip manajemen kelas, mengatur lingkungan kelas, menciptakan atmosfer yang positif dalam kelas, menerapkan peraturan, dan terjalin komunikasi yang baik dengan guru sebagai fasilitator. Adanya manajemen kelas dalam mencapai pembelajaran yang efektif dapat meningkatkan motivasi belajar siswa dan menjadikan pembelajaran lebih terarah. Selain itu, diperlukan pula kontribusi orang tua siswa dalam membimbing dan mendampingi siswa selama pembelajaran daring yang dilakukan dari rumah.Kata Kunci: inovasi manajemen kelas, pembelajaran daring, motivasi belajar, sekolah dasar
Клініко-патофізіологіне обґрунтування синдрому взаємного обтяження у постраждалих з бойовою комбінованою термо-механічною травмою та вогнепальними переломами довгих кісток
Authors: Palii I. P. 
Published: January 2024

Мета. Проаналізувати особливості змін гомеостазу у постраждалих з бойовою комбінованою термо-механічною травмою (БКТМТ) та науково обґрунтувати оцінку тяжкості цих ушкоджень з подальшим передбаченням розвитку синдрому взаємного обтяження (СВО).
Матеріали та методи. Проведено порівняльне комплексне клінічне обстеження 178 постраждалих, які було розподілено на 51 постраждалих основної та 127 додаткової клінічної груп із вогнепальним ізольованим переломом стегнової кістки, ізольованими опіками тіла І ст., ІІІ ст., та постраждалих з тяжкою, вкрай тяжкою БКТМТ у яких вогнепальний перелом довгих кісток як провідний компонент комбінувався з опіками тіла.
Результати. У зв'язку з цим ми зробили висновок, що у постраждалих з вкрай тяжкою БКТМТ, коли вогнепальний перелом довгих кісток комбінувались з тяжкими позаскелетними ушкодженнями (опіками), розвиваються специфічні розлади гомеостазу у відповідь на механічну травму у вигляді СВО, який і зумовлює летальний кінець.
Висновки. Найбільш достовірно тяжкість стану постраждалих з БКТМТ відображають такі показники гомеостазу, як разова продуктивність серця, коефіцієнт інтегральної тонічності судин, показник напруженості дихання, показник стабілізації тонусу судин, показник виразності дихально-циркуляторних розладів. Ізольований перелом довгих кісток є тяжким ушкодженням, яке при поєднанні з тяжкими позаскелетними ушкодженнями (опіками) зумовлює СВО.
Вивчення фармакокінетичних показників лікарського засобу під умовною назвою «МІЛР-КРЕМ» методом in Vivo
Authors: Ostaschenko T. M. 
Published: January 2024

Вступ. Фармацевтична розробка нового лікарського засобу (ЛЗ) передбачає всебічне вивчення показників, що впливають на фармако-технологічні, біофармацевтичні властивості препарату. Серед біофармацевтичних досліджень особливу увагу звертає дослідження фармакокінетики препарату методами in vitro та in vivo. Метод in vitro моделює вивільнення активних фармацевтичних інгредієнтів (АФІ) через мембрану, яку можна розглянути як штучну біомембрану (шкіру). На підставі цього дослідження можна судити про кінетику хімічної реакції, а також про порядок вивільнення АФІ з основи. Дані процеси можна вивчити методом in vivo, який моделює «програму» вивільнення АФІ в кров або шкіру. Однак прямої кореляції між методами in vitro та in vivo не існує. Тому для нас стало актуальною проведення фармакокінетичних лосліджень методом in vivo.
Метою даного дослідження стало вивчення фармакокінетичних показників розробленого ЛЗ методом in vivo на щурах.
Матеріали та методи дослідження. В ході дослідження нами після вивчення специфічної активності препарату на щурах були відібрані біологічні матеріали – кров та шкіра з м`язовими тканинами. Для цього кров була відібрана з хвостової вени щурів, а тканини – після декапітації тварин. Дослідження фармакокінетики препарату методом in vivo проводили на 5 щурах. Проведення ізолювання та виявлення АФІ проводили на базі кафедри біотехнології, біофізики і аналітичної хімії Національного технічного університету «ХПІ» (м. Харків) під керівництвом д.тех.н., проф. Близнюк О. М. (метод ВЕРХ згідно Договору між НУОЗ імені П. Л. Шупика та «ХПІ») та проф. Давтян Л. Л. (ізолювання речовин з крові та тканин).
Результати. На основі експериментальних даних нами встановлено, що препарат не всмоктується в кров. Отже, препарат є місцевої дії. Для підтвердження нашого припущення щодо місцевої дії препарату нами вивчено концентрацію АФІ в шкіри з м`язовими тканинами при аплікаційному введенні препарату. Для цього 0,1 г подрібненої шкіри із м’язовою тканиною заливали 20мл ацетонітрилу та екстрагували на орбітальному шейкері впродовж 30 хв. Ацетонітрильний екстракт кількісно переносили в мірну колбу (50 мл) та доводили до мітки ацетонітрилом. Отриманий розчин перемішували, фільтрували та досліджували методом ВЕРХ.
Висновки. При аплікаційному способі введення ЛЗ фармакокінетичні параметри залежать від фармацевтичних факторів, зокрема розчинності, способу введення АФІ до основи та самої основи.Фармакокінетичні показники використовуються для оцінки зміни концентрацій АФІ в залежності від часу в специфічній камері, де виявляється терапевтична дія препарату. Отже нами доведено, що терапевтичний ефект ЛЗ пов’язана з його концентрацією в тканинах (препарат місцевої дії).
Desenvolvimento dentário em crianças com Microcefalia: série de casos
Authors: Oliveira Anna Liz Santos , Velame Maria Leticia Menezes , Ramos Maislla Mayara Silva , Bonfim Rita de Cássia Riséio , Pedreira Kaynã Silva , Ismerim Adna Barros , Viana Rita de Cássia Dias , Monteiro Adriano Monteiro D'Almeida , De Freitas Maria da Conceição Andrade 
Published: January 2024

O objetivo deste estudo pretendeu descrever a cronologia e sequência de erupção dentária de crianças com microcefalia. Trata-se de um estudo qualitativo transversal observacional do tipo relato de casos clínicos. Foram analisadas 5 crianças, ambos os sexos, 6 a 8 anos de idade, diagnosticadas com microcefalia grave sem síndromes ou outras anomalias craniofaciais relacionadas. Nos exames intrabucais e radiográficos, as crianças apresentaram alterações na sequência de erupção dentária e atraso na erupção dos primeiros molares permanentes. Fatores como o alto grau de aumento gengival generalizado induzido por biofilme e potencializado pelo uso frequente de fármacos anticonvulsivantes contribuíram para a ocorrência do atraso nas erupções dentárias dos primeiros molares permanentes.
Pro-inflammatory activation of monocytes in patients with immunoinflammatory rheumatic diseases
Authors: Bogatyreva A. I. , Gerasimova E. V. , Kirichenko T. V. , Markina Yu. V. , Popkova T. V. , Shalygina M. V. , Tolstik T. V. , Markin A. M. , Orekhov A. N. 
Published: January 2024

The pathogenesis of immunoinflammatory rheumatic diseases (IRDs) is based on chronic inflammation, one of the key mechanisms of which may be abnormal activation of macrophages, leading to further disruption of the immune system.The aim – to evaluate the pro-inflammatory activation of circulating monocytes in patients with IRDs.Material and methods. The study included 149 participants: 53 patients with rheumatoid arthritis (RA), 45 – with systemic lupus erythematosus (SLE), 34 – with systemic scleroderma (SSc) and 17 participants without IRD, aged 30 to 65 years. Basal and lipolysaccharide (LPS)-stimulated secretion of monocytes was studied in a primary culture of monocytes obtained by immunomagnetic separation from blood. Quantitative assessment of the cytokines tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β) and the monocyte chemoattractant protein-1 (MCP-1) was carried out in the culture fluid by ELISA. Pro-inflammatory activation of monocytes was calculated as the ratio of LPS-stimulated and basal secretions.Results. It was shown that the basal secretion of all studied cytokines was significantly increased in all groups of patients with IRDs, except for the secretion of IL-1β in the SLE group, compared with the control. LPS-stimulated secretion of TNF-α was increased and MCP-1 was decreased in patients with IRDs compared to the control group; LPS-stimulated IL-1β secretion only in the SSc group was significantly different from the control group. In the RA group, monocyte activation was reduced for all cytokines compared to the control, in the SLE group – for TNF-α and MCP-1, in the SSc group – for MCP-1.Conclusion. The decrease in pro-inflammatory activation of monocytes in patients with IRDs is due to a high level of basal secretion of cytokines, which can lead to disruption of the adequate immune response in these diseases and is an important link in the pathogenesis of chronic inflammation.
Anti-carbamylated protein antibodies in ACCP-negative and ACCP-positive patients with rheumatoid arthritis
Authors: Dibrov D. A. , Avdeeva A. S. , Diatroptov M. E. , Nasonov E. L. 
Published: January 2024

Objective. Assess the level of antibodies to carbamylated proteins (anti-CarP) and analyse the clinical and immunological associations in patients with ACCP-negative and ACCP-positive variants of rheumatoid arthritis.Materials and methods. 150 patients with a reliable diagnosis of rheumatoid arthritis and 25 patients as healthy controls were included in the study. Depending on ACCP values, two groups of patients were recruited: ACCP-positive (n=75) and ACCP-negative (n=75). RA activity was assessed by the DAS28 (Disease Activity Score 28) index. Determination of antibodies to carbamylated proteins was performed by enzyme-linked immunosorbent assay (BlueGene Biotech, China). Quantitative determination of ACCP in serum was performed by enzyme immunoassay using a commercial reagent kit (AxisShield, UK; upper limit of normal 5.0 U/ml; Orgentec, Germany; upper limit of normal 20.0 U/ml).Results and discussion. Me for anti-CarP in patients with RA was 126.2 [100.83; 157.41] ng/ml and was statistically significantly higher (p<0.001) than healthy controls 88.89 [70.53; 107.75] ng/ml. Among all patients with RA, 50 (33.3%) were anti-Carp positive, 22 (29.3%) were anti-Carp(+) in the ACCP(+) group, 28 (37.3%) in the ACCP(–) group, and 1 (2%) volunteer from healthy controls (p=0.002). In ROC analysis to assess the diagnostic significance of anti-Carp for RA for all patients with RA, the area under the curve was 0.783±0.047 (95% CI: 0.691–0.874; p<0.001), with a cut-off point of 143 ng/ml, specificity 96%, sensitivity 36.7%.In the ACCP(+) RA group, the erosion count was statistically significantly higher (p=0.044) in anti-CarP(+) patients than in anti-CarP(–) patients. A weak direct correlation between anti-CarP and DAS28 was found in the ACCP(–) RA group.Conclusion. We studied the predictive value of anti-CarP as an adjuvant biomarker in ACCP(+) and ACCP(–) subtypes of RA. ACCP(+), anti-CarP(+) patients have a more “erosive” subtype of the disease than ACCP(+), anti-CarP(–) patients. In ACCP(+) patients, anti-CarP helps to identify a more erosive subtype of the disease, and among ACCP(–) patients, it helps to reduce the proportion of seronegative patients. Further studies are needed to determine the optimal standards for the laboratory diagnosis of anti-CarP and to clarify the diagnostic potential of these antibodies as part of the differential diagnosis of arthritis in other rheumatic diseases.
DETERMINAN FAKTOR YANG MEMPENGARUHI KADAR ASAM URAT PADA LANSIA YANG MENDERITA ASAM URAT DI KABUPATEN TULUNGAGUNG
Authors: Nizar Angga Miftakhul , Zuniawati Dewi 
Published: January 2024

Older people are at high risk of developing metabolic diseases such as high uric acid. The ability to do a protein diet needs to be improved in gout sufferers. The purpose of this thesis is to determine the relationship between dietary compliance and uric acid levels in the elderly at the Elderly Posyandu at, Tulungagung in 2023.
The design used in this study is a corelational analytic design with a cross sectional approach. The population of this study were all elderly people suffering from gout at the Elderly Posyandu, Srikaton Village, Ngantru District, Tulungagung Regency, totaling 34 elderly people. The research sample was all elderly people suffering from gout at the Elderly Posyandu, Srikaton Village, Ngantru District, Tulungagung Regency, totaling 34 elderly people. In this study the sampling technique is total sampling. The research instruments were observation sheets and questionnaires equipped with general research data. Data processing in the form of editing, coding, scoring, tabulating was analyzed using the Spearman rho test.
Based on the results of the study, the value of ρ was obtained (0.000) with α (0.05), because ρ <α, then H1 is accepted, meaning that there is a relationship between dietary compliance and uric acid levels in the elderly at the Elderly Posyandu Tulungagung in 2023.
It can be concluded that it is important for the elderly to comply with the diet to avoid excess uric acid levels. The inability of the elderly to control and maintain diet patterns is also complicated by the elderly where at that age there is a decrease in body function so that the regulation and balancing of the disposal of uric acid levels in the body is not good.
An Overview of the Adoption of eAssessment Among Moroccan Primary School Teachers: Factors and Challenges
Authors: Es-sarghini Abdelghani , Boumahdi Abdelaziz 
Published: January 2024

This study provides a comprehensive investigation of how primary school teachers in the Marrakech-Safi region of Morocco integrate information and communication technologies (ICTs) into their assessment practices. Gathering data through a questionnaire disseminated via email, the research garnered 346 valid responses, indicating a modest implementation of ICTs in assessment processes, with a small fraction of teachers applying them consistently. Interestingly, the findings demonstrate that experienced educators are more inclined to employ ICT in assessments. Despite the prevalent practice of offering eAssessment training to Moroccan primary school teachers as a means to bolster their capabilities in technology-enhanced assessment, such professional development has not been a significant factor in encouraging the use of ICT-based assessment tools among teachers who do not already utilize them. The investigation also delves into the types of eAssessment methods employed, including interactive tests, simulations, and problem-solving activities. The research underscores the necessity for additional exploration and support systems to advance effective ICT adoption in educational assessments. The research has substantial implications for the enhancement of educational assessment practices, informing policy-makers and practitioners about the current state of eAssessment and guiding future efforts to optimize the evaluation of student knowledge in a digital era.

Received: 30 November 2023 | Revised: 29 December 2023 | Accepted: 31 December 2023

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The participants of this study did not give written consent for their data to be shared publicly, so due to the sensitive nature of the research supporting data is not available.