bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oxidation state and distribution of Fe in pumpellyite from the Northern Chichibu Belt in the Hijikawa district, western Shikoku, Japan
Authors: Akasaka Masahide , Goishi (Imaizumi) Yumi , Sakakibara Masayuki , Nakamuta Yoshihiro 
Published: October 2023

AbstractIntracrystalline distribution of ferrous and ferric iron within pumpellyites (VIIW8VIX4VIY8IVZ12O56–n(OH)n, Z = 1) from low-grade metamorphic green rocks of the Kanogawa unit in the Northern Chichibu Belt, Hijikawa district, western Shikoku, Japan, was investigated using electron microprobe analysis, X-ray Rietveld refinement, and 57Fe Mössbauer spectroscopic analysis to verify the regularity of the distribution of Fe within the octahedral X and Y sites in pumpellyite and its effect on the pumpellyite structure. Two Fe-rich pumpellyite samples, labelled CLW and CHG, with average total Fe2O3 of 10.01±1.69 and 16.07±1.08 wt.%, respectively, were separated from the rock samples. The site occupancies at the X and Y sites in the CLW and CHG pumpellyites, refined using powder X-ray diffraction data, are X[Mg0.298Fe0.298(5)Al0.405]Y[Fe0.191Al0.809] and X[Mg0.244Fe0.42(1)Al0.34]Y[Fe0.32Al0.68], respectively. The Fe2+:Fe3+ ratio of the CLW pumpellyite, determined using Mössbauer spectroscopy, is 12(1):88(3). By combining the average chemical composition data, the site occupancies at the X and Y sites, and the Fe2+:Fe3+ ratio of the CLW pumpellyite, the chemical formulae of CLW and CHG pumpellyites are constructed as (Ca7.96K0.02Na0.01)Σ7.99(Mg1.19Mn2+0.09Fe2+0.39Fe3+0.71Al1.62)Σ4.00(Al6.47Fe3+1.50V0.02Ti0.01)Σ8.00Si12.26O43.33(OH)12.67 and (Ca8.01K0.01)Σ8.02(Mg0.97Mn2+0.02Fe2+0.63Fe3+1.03Al1.19)Σ4.01(Al5.44Fe3+2.55V0.01)Σ8.00Si12.02O42.69OH)13.31, respectively, implying that the proper name of both pumpellyites is pumpellyite-(Al). The intracrystalline distribution coefficients of Fe3+ versus Al between the X and Y sites, KD = (Fe3+/Al)X/(Fe3+/Al)Y, are 1.62 and 1.90 for the CLW and CHG pumpellyites, respectively, implying stronger X-site preference of Fe3+ than Al3+. In the CHG pumpellyite, where the Fe contents at the X and Y sites are higher than in the CLW pumpellyite, the mean <X–O> and <Y–O> distances are 2.06 and 1.98 Å, respectively, which are larger than <X–O> = 2.040 and <Y–O> = 1.944 Å in the CLW pumpellyite. The unit-cell parameters of the CHG pumpellyite are a = 8.8672(3), b = 5.9562(2), c = 19.1899(6) Å, β = 97.473(2)° with V = 1004.9(2) Å3 and are larger than those of the CLW pumpellyite, a = 8.8456(4), b = 5.9393(2), c = 19.1613(8) Å, β = 97.461(3)° with V = 998.14(7) Å3.
Pre-compensation of Friction for CNC Machine Tools through Constructing a Nonlinear Model Predictive Scheme
Authors: Xiao Qunbao , Wan Min , Qin Xuebin 
Published: October 2023

AbstractNonlinear friction is a dominant factor affecting the control accuracy of CNC machine tools. This paper proposes a friction pre-compensation method for CNC machine tools through constructing a nonlinear model predictive scheme. The nonlinear friction-induced tracking error is firstly modeled and then utilized to establish the nonlinear model predictive scheme, which is subsequently used to optimize the compensation signal by treating the friction-induced tracking error as the optimization objective. During the optimization procedure, the derivative of compensation signal is constrained to avoid vibration of machine tools. In contrast to other existing approaches, the proposed method only needs the parameters of Stribeck friction model and an additional tuning parameter, while finely identifying the parameters related to the pre-sliding phenomenon is not required. As a result, it greatly facilitates the practical applicability. Both air cutting and real cutting experiments conducted on an in-house developed open-architecture CNC machine tool prove that the proposed method can reduce the tracking errors by more than 56%, and reduce the contour errors by more than 50%.
Carrier lifetime modulation on current capability of SiC PiN diodes in a pulsed system
Authors: Xu Xingliang , Zhang Lin , Li lianghui , Li Zhiqiang , Li Juntao , Zhang Jian , Dong Peng 
Published: October 2023

AbstractSilicon carbide (SiC) PiN diode has shown substantial promise as the freewheel diode for switch protection in a pulsed system. In this paper, we investigate the carrier lifetime (τ) modulation on pulsed current capability of SiC PiN diodes. The carrier lifetime in 4H–SiC is modulated by the generation of the Z1/2 center through neutron irradiation. Surprisingly, we found that the pulsed current of SiC PiN diodes shows a limited improvement when the carrier lifetime (τ) increases from 0.22 to 1.3 μs, while is significantly promoted as the carrier lifetime increases from 0.03 to 0.22 μs. This changing trend is obviously different from the on-state resistance, which decreases with the increased carrier lifetime. The simulation result indicates that the heat generation (i.e., maximum temperature rise) inside the PiN diodes, especially in the drift layer, is remarkably aggravated in the pulse tests for τ < 0.1 μs, but which is significantly suppressed as carrier lifetime rises to 0.2 μs and above. Therefore, the dependence of pulsed current on carrier lifetime is ascribed to the heat generation resulting from the carrier lifetime controlled conductivity modulation effect, which hence affects the temperature rise and brings about the failure of SiC PiN diodes under high pulsed current.
Metabolomics in severe traumatic brain injury: a scoping review
Authors: Fedoruk Riley Page , Lee Chel Hee , Banoei Mohammad Mehdi , Winston Brent W. 
Published: October 2023

Abstract
Background
Diagnosis and prognostication of severe traumatic brain injury (sTBI) continue to be problematic despite years of research efforts. There are currently no clinically reliable biomarkers, though advances in protein biomarkers are being made. Utilizing Omics technology, particularly metabolomics, may provide new diagnostic biomarkers for sTBI. Several published studies have attempted to determine the specific metabolites and metabolic pathways involved; these studies will be reviewed.

Aims
This scoping review aims to summarize the current literature concerning metabolomics in sTBI, review the comprehensive data, and identify commonalities, if any, to define metabolites with potential clinical use. In addition, we will examine related metabolic pathways through pathway analysis.

Methods
Scoping review methodology was used to examine the current literature published in Embase, Scopus, PubMed, and Medline. An initial 1090 publications were identified and vetted with specific inclusion criteria. Of these, 20 publications were selected for further examination and summary. Metabolic data was classified using the Human Metabolome Database (HMDB) and arranged to determine the ‘recurrent’ metabolites and classes found in sTBI. To help understand potential mechanisms of injury, pathway analysis was performed using these metabolites and the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway Database.

Results
Several metabolites related to sTBI and their effects on biological pathways were identified in this review. Across the literature, proline, citrulline, lactate, alanine, valine, leucine, and serine all decreased in adults post sTBI, whereas both octanoic and decanoic acid increased. Hydroxy acids and organooxygen compounds generally increased following sTBI, while most carboxylic acids decreased. Pathway analysis showed significantly affected glycine and serine metabolism, glycolysis, branched-chain amino acid (BCAA) metabolism, and other amino acid metabolisms. Interestingly, no tricarboxylic acid cycle metabolites were affected.

Conclusion
Aside from a select few metabolites, classification of a metabolic profile proved difficult due to significant ambiguity between study design, sample size, type of sample, metabolomic detection techniques, and other confounding variables found in sTBI literature. Given the trends found in some studies, further metabolomics investigation of sTBI may be useful to identify clinically relevant metabolites.
Prevalence of pediatric sepsis in hospitalized children of Maiwand Teaching Hospital, Kabul, Afghanistan
Authors: Sediqi Mohammad Sharif , Wali Abdulwali , Ibrahimi Mohammad Akbar 
Published: October 2023

Abstract
Background
Sepsis is a clinical syndrome associated with a systemic reaction to infection that is seen as a bacteremia with systemic symptoms. Sepsis is one of the most important problems in children and is associated with many deaths, so recognizing this disease and it’s causing factors and identifying the predisposing factors for it is of great importance. Globally, the prevalence and occurrences of sepsis and septic shock are increasing, while the incidence of deaths from them has decreased with the improvement of diagnostic and treatment facilities. According to a 2015 World Health Organization report, approximately 5.9 million children under 5 years old have lost their lives due to sepsis worldwide, the majority of which have occurred in developing countries.

Methods
This study was conducted in the pediatric department of Maiwand Teaching Hospital (MTH) in 2020 as a descriptive cross-sectional study. All children who were admitted to the pediatric department of Maiwand Teaching Hospital during 2020 were included in the research. Among them, the prevalence of sepsis in children with respect to age and sex was studied. The study included children over the age of 28 days who were admitted to the Maiwand Teaching Hospital pediatrics department in 2020. However, in this study, patients have been categorized into five categories according to age: less than two months, two months to one year, one to three years, three to five years old, and older than five years old.

Results
This study was conducted in the pediatric department of Maiwand Teaching Hospital in 2020 as a descriptive cross-sectional study, and it was found that the prevalence of sepsis in children who were admitted to the pediatric department at this year was 50.5%, including the highest prevalence in males (65.75%) and at the age of two months to one year (37.9%). In this study, it was found that the prevalence of sepsis was higher (88.46%) among urban children than children who were living in villages (11.53%). In this study, the mortality rate was 2.44% for patients admitted to Maiwand Teaching Hospital.

Conclusions
In this study, it was found that the prevalence of sepsis was 50.5% in children admitted to the pediatrics department of Maiwand Teaching Hospital, of whom 67.75% were boys, 37.94% were aged two months to three years old, and it was more prevalent (88.46%) among children living in cities. The mortality rate was 2.44%.
Determination and prioritization of factors affecting the occurrence of needle stick injuries among healthcare workers using techniques of Delphi and fuzzy analytical hierarchy process (FAHP)
Authors: Mousavi Seyed Mahdi , Yazdanirad Saeid , Althubiti Sara , Majdabadi Masoud Askari , Najarian Faranak , Sepehr Parvin 
Published: October 2023

Abstract
Introduction
Needlestick injuries (NSIs) are a major hazard in the workplace for healthcare workers. To prevent these injuries, it is essential to determine the important factors affecting the occurrence of them. This study aimed to identify, classify and prioritize these factors using techniques of Delphi and fuzzy analytical hierarchy process (FAHP).

Methods
This descriptive-analytical study was conducted in 2022. Firstly, the factors affecting the occurrence of needlestick injuries were identified by the literature review. Moreover, the Delphi technique was used to identify the factors. 20 experts (physicians, nurses, and occupational health experts) participated in the steps of the Delphi method. Then, these factors were grouped into six groups. In the next step, the fuzzy analytical hierarchy process (FAHP) was applied to prioritize the factors. For this purpose, the pairwise comparison questionnaire was designed and filled out by 20 experts. Finally, data were analyzed using MATLAB software (version 2018a).

Results
42 factors (31 factors extracted from the literature review and 11 factors obtained from the Delphi technique) were identified in this study. These factors were categorized into six groups. Based on the results, the relative weight of non-demographic personal factors, tool and technology factors, job factors, organizational factors, demographic personal factors, and environmental factors were computed by 0.200, 0.185, 0.184, 0.157, 0.142, and 0.133, respectively.

Conclusion
These results determined the importance of the factors affecting the occurrence of needlestick injuries. These findings can be useful for planning preventive measures.
Establishment of prognostic model of bladder cancer based on apoptosis-related genes, in which P4HB promotes BLCA progression
Authors: Zou Zhenhai , Li Zhong , Sun Wei , Gao Wuyue , Liu Beibei , Liu Jianmin , Guo Yuanyuan 
Published: October 2023

Abstract
Background
A variety of apoptosis genes have been confirmed to be related to the occurrence and development of bladder cancer patients, but few studies have paid attention to their significance in the prognosis of bladder cancer. Therefore, this study explored the value of apoptosis-related genes in the prognosis of BLCA by using the data in TCGA database.

Methods
We downloaded the mRNA expression profiles and corresponding clinical data of bladder cancer patients from TCGA database, and obtained 2411 apoptosis-related genes from Deathbase database. Screening out differentially expressed apoptosis-related genes. Cox regression was used to determine the prognostic value of apoptosis-related genes, and then a prognostic risk model was developed. A nomogram based on risk model was constructed to predict the prognosis of bladder cancer patients. At the same time, immune infiltration correlation analysis of genes in the prognosis model.

Results
A prognostic model composed of 12 apoptosis-related genes was constructed. According to the risk score calculated by the model, patients were divided into high-risk group and low-risk group. There are significant differences in the expression of immune cells, immune function and immune checkpoint molecules between high-risk group and low-risk group. P4HB may promote bladder cancer progression.

Conclusion
Based on the differential expression of apoptosis-related genes, we established a risk model to predict the prognosis of bladder cancer patients, in which P4HB promotes BLCA progression.
Experience of verbal violence among Chinese nursing students in clinical practice: a qualitative study
Authors: Qian Meiyan , Zhu Pingting , Wu Qiwei , Wang Wen , Shi Guanghui , Ding Yinwen , Zhang Hui , Gu Xinyue , Xu Ting , Zhang QianQian 
Published: October 2023

Abstract
Background
Workplace violence is prevalent in the nursing profession, and as a relatively junior link of the professional hierarchy, nursing students are not immune to it. Among these, verbal violence may have more serious consequences for the victims than physical violence, but the literature on verbal violence among nursing students in Chinese clinical settings is limited.

Aims
To explore the verbal violence experience among Chinese nursing students in clinical practice, and the strategies used by nursing students to cope with violence.

Design
A descriptive qualitative study.

Methods
From January 2022 to June 2022, semi-structured interviews were conducted with 21 nursing students in clinical practice by purposive snowball sampling. Nvivo12 software and inductive content analysis were used for data analysis. This paper followed the COREQ (Consolidated criteria for Reporting Qualitative Research) guidance.

Results
Through data analysis, three themes were defined:(1) Multiform verbal violence; (2) Hurting and impacting and (3) Struggling or Coping. The findings indicated that nursing students were subjected to multiple forms of verbal violence in clinical practice, not only from patients and caregivers, but also from peers such as clinical tutors and doctors, which not only harmed students’ personal health and well-being, but may also contribute to the nursing industry’s future loss of human resources. Seeking emotional support from others and forcing themselves to grow up were the most commonly used coping strategies.

Conclusion
Nursing educators and nursing managers need to pay attention to verbal violence in the clinical environment, and actively develop the ability of nursing students to deal with uncivilized behavior. Establishing relevant courses and training such as communication, resilience, and violence prevention, establishing a stricter clinical mentor appointment system, and teaching assessment system may be strategies to help nursing students better perform clinical practice.
Assessing user preferences for design characteristics of oral dissolvable strips for pediatric HIV medication: a qualitative study
Authors: Wexler Catherine , Maloba May , Sliefert Michala , Babu Shadrack , Maosa Nicodemus , Maliski Edward , Nicolay Zachary , Were Frederick , Mbithi Yvonne , Mugendi George , Thomas Gregory , Acharya Harshdeep , Finocchario-Kessler Sarah 
Published: October 2023

Abstract
Background
Current infant antiretroviral therapy formulations pose barriers to daily adherence due to complex weight-based dosing, conspicuous preparation, and poor palatability. These adherence barriers jeopardize adherence, making patients vulnerable to virologic failure, development of drug resistance, and preventable mortality. Our team has previously established proof-of-principle for multi-drug oral dissolvable strips as alternative pediatric antiretroviral formulations with the potential to overcome these challenges and improve pediatric ART adherence and outcomes. The objective of this study was to assess caregiver and provider preferences for oral dissolvable strips and its packaging to inform its development.

Methods
Guided by concepts of user-centered design, we conducted key informant interviews with 30 HIV care providers and focus group discussions targeting caregivers of children < 10 years of age living with HIV at 3 Kenyan hospitals. Key informant interviews and focus group discussions were audio recorded, translated/transcribed verbatim, and hand coded for a-priori and emergent themes.

Results
A total of 30 providers and 72 caregivers (caring for 83 children, aged 5 months to 18 years) participated in the study. Caregivers and providers expressed a strong desire for an easier way to administer medication, especially among children too young to swallow tablets whole, and expressed enthusiasm around the idea of oral dissolvable strips. Key preferences included a pleasant taste; one strip per dose; small size with rapid dissolution; clear markings and instructions; and no special storage requirements. For packaging, stakeholders preferred individually wrapped strips within a dispenser. The individual packaging should be durable, waterproof, and easy to dispose of in communal spaces. They should also be easy to open, with clear indications where to open. The packaging holding the strips should be durable, re-usable, accommodating of various refill frequencies, and easy to use for children as young as 6.

Discussion
The concept of oral dissolvable strips was highly acceptable to caregivers of children living with HIV and HIV care providers. By engaging stakeholders in an iterative design process starting from the early phases of design and development, we will maximize the likelihood of developing a product that is acceptable to the caregiver and infant, therefore leading to sustainable adherence.
What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study
Authors: An Hoyoung , Yang Hee Won , Oh Dae Jong , Lim Eunji , Shin Jin , Moon Dong Gyu , Suh Seung Wan , Byun Seonjeong , Kim Tae Hui , Kwak Kyung Phil , Kim Bong Jo , Kim Shin Gyeom , Kim Jeong Lan , Moon Seok Woo , Park Joon Hyuk , Ryu Seung-Ho , Lee Dong Woo , Lee Seok Bum , Lee Jung Jae , Jhoo Jin Hyeong , Bae Jong Bin , Han Ji Won , Kim Ki Woong 
Published: October 2023

Abstract
Background
Integrating a joint approach to chronic disease management within the context of a couple has immense potential as a valuable strategy for both prevention and treatment. Although spousal concordance has been reported in specific chronic illnesses, the impact they cumulatively exert on a spouse in a longitudinal setting has not been investigated. We aimed to determine whether one’s cumulative illness burden has a longitudinal impact on that of their spouse.

Methods
Data was acquired from a community-based prospective cohort that included Koreans aged 60 years and over, randomly sampled from 13 districts nationwide. Data from the baseline assessment (conducted from November 2010 to October 2012) up to the 8-year follow-up assessment was analyzed from October 2021 to November 2022. At the last assessment, partners of the index participants were invited, and we included 814 couples in the analysis after excluding 51 with incomplete variables. Chronic illness burden of the participants was measured by the Cumulative Illness Rating Scale (CIRS). Multivariable linear regression and causal mediation analysis were used to examine the longitudinal effects of index chronic illness burden at baseline and its change during follow-up on future index and spouse CIRS scores.

Results
Index participants were divided based on baseline CIRS scores (CIRS < 6 points, n = 555, mean [SD] age 66.3 [4.79] years, 43% women; CIRS ≥ 6 points, n = 259, mean [SD] age 67.7 [4.76] years, 36% women). The baseline index CIRS scores and change in index CIRS scores during follow-up were associated with the spouse CIRS scores (β = 0.154 [SE: 0.039], p < 0.001 for baseline index CIRS; β = 0.126 [SE: 0.041], p = 0.002 for change in index CIRS) at the 8-year follow-up assessment. Subgroup analysis found similar results only in the high CIRS group. The baseline index CIRS scores and change in index CIRS scores during follow-up had both direct and indirect effects on the spouse CIRS scores at the 8-year follow-up assessment.

Conclusions
The severity and course of one’s chronic illnesses had a significant effect on their spouse’s future chronic illness particularly when it was severe. Management strategies for chronic diseases that are centered on couples may be more effective.