bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization
Authors: Kim Yeon-Yong , Jeong Seungwon , Lee Seung , Lee Seung-Jae , Rho Mun-Chual , Kim Sang-Hyun , Lee Soyoung 
Published: November 2023

Abstract

Objective: Asthma is an airway inflammatory disease caused by activation of numerous immune cells including macrophages. Bakuchicin (BKC) is known to exhibit anti-inflammatory effects and type 2 T helper (Th2) regulation, but has not been investigated for airway inflammation. This study aimed to evaluate the effects of BKC on airway inflammation and demonstrate the mechanisms of macrophage polarization.
Methods: The anti-inflammatory effects were determined using lipopolysaccharide (LPS)-stimulated macrophages. The ovalbumin (OVA)-induced asthma mouse model was used to evaluate the effects of BKC on airway inflammation and Th2 responses. Moreover, the effect of BKC on macrophage polarization was confirmed in bone marrow-derived macrophages (BMDMs) differentiation.
Results: BKC suppressed nitric oxide production and expression of pro-inflammatory cytokines by inhibiting signaling pathway in LPS-stimulated macrophages. In an OVA-induced asthma model, BKC treatment alleviated histological changes and mast cell infiltration and reduced the levels of eosinophil peroxidase, β-hexosaminidase, and immunoglobulin levels. In addition, BKC alleviated Th2 responses and M2 macrophage populations in bronchoalveolar fluid. In BMDMs, BKC suppressed IL-4-induced M2 macrophage polarization and the expression of M2 markers such as arginase-1 and Fizz-1 through inhibiting sirtuin 2 levels.
Conclusion: BKC could be a drug candidate for the treatment of allergic asthma.
Appraisal on hepatocellular carcinoma in male rats via reducing oxidative stress and inflammatory markers of isothiocyanate-rich dichloromethane extracts from Brassica oleracea as a natural protector agent
Authors: Mohammed Mona A. , ahmed doha ,   Fatma A. A. Ibrahim2, Hassan Nabila S , bashandy Samir AE , gengaihi souad 
Published: November 2023

Abstract

The cruciferous vegetable kale (Brassica olraceae var. sabellica 'Lacinato') is a new Egyptian cultivar originating from the USA. We implanted it in sandy and clay soils. The sandy soil has higher concentrations of glucosinolates and total isothiocyanate (TITC) than the clay soil. This study used a multi-purpose chromatographic technique to analyze it, which simultaneously separates glucosinolates and isothiocyanate by hydrolysis methods with the measure by spectrophotometer-methods at 320 nm for isothiocyanate, giving 1.62 ug/g in dichloromethane extract, and 425 nm for glucosinolates, giving 4.32 ug/g in sandy soil compared to HPLC methods, giving 2.06 ug/ml as glucoraphanin and 58.51 ug/ml as sulforaphane. Kales have different biological effects as anti-inflammatory and antioxidant. In the existing study, twenty-four male rats were sorted into four groups: control group, hepatocellular carcinoma (HCC) rats, HCC rats treated with 15 mg/kg TITC (orally), and HCC rats treated with 30 mg/kg TITC (orally). A significant decrease in the plasma level of cancer markers (glypican-3 (GPC3), vascular endothelial growth factor (VEGP), and alpha-fetoprotein (AFP)) as compared to the DEN group was recorded in HCC rats treated with TITC. The medication of HCC rats with ITC restrained the significant rise in enzymes of the liver, glucose, triglycerides, cholesterol, and histopathological changes. Also, ITC relieved the increase in the inflammatory markers tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Moreover, the rats given ITC and DEN showed a significant decrease in hepatic nitric oxide (NO), malondialdehyde (MDA), and a significant enhancement in reduced glutathione (GSH) as compared to the DEN group. The histopathological changes were lowered by TITC treatment. We can conclude that the hypolipidemic, antioxidant, and anti-inflammatory properties of TITC may contribute to its protective effect against DEN-induced HCC.
Moving Together - benefits of an online dance program on physical and mental health for older adults: a mixed-method study
Authors: Hansen Rasmus Kopp , Jochum Elizabeth , Egholm Ditte , Villumsen Morten , Hirata Rogerio Pessoto 
Published: November 2023

Abstract

Background
Previous studies show that in-person dance training is a beneficial form of physical activity that involves mental, social, and physical dimensions. This study investigated the benefits of a 12-week online dance training intervention on mental and physical health outcomes for older adults.
Methods
A convergent parallel mixed-method design was used. Forty-five older adults (74.0 ± 5.3 yrs old, 44 women) were recruited through advertisements at activity and rehabilitation centers in the North Denmark region. The intervention consisted of two weekly 60-min classes of improvisation and salsa delivered online through video call applications. Changes in physical health outcomes (body mass and composition, resting blood pressure, Senior Fitness Test battery) and self-rated health and wellbeing (health-related quality of life (HRQOL), feelings of loneliness) were assessed prior to and after 12 weeks of dancing. Focus group interviews were conducted post-intervention to further explore the benefits as well as the participant’s experience of the intervention. Thematic analysis of the qualitative data was conducted.
Results
Thirty-two participants completed the study. Significant improvements in fitness were found for the number of arm curls performed (baseline: 12.3 ± 3.0; post-intervention: 13.7 ± 3.0, P = 0.005), 2-min step test performance (baseline: 66.5 ± 20.0 reps.; post-intervention: 73.8 ± 22.6 reps., P = 0.016), and chair sit-and-reach (baseline: 0.4 ± 11.3 cm; post-intervention: 5.5 ± 10.1 cm, P < 0.001). There was a significant increase in body mass from baseline to post-intervention (P < 0.015). The themes from the focus groups included (1) Participation, (2) Challenges, (3) Progression, (4) Motivation, (5) Perceived health and wellbeing, and (6) Online dance instruction. No significant changes were reported in HRQOL and loneliness from the quantitative data, although the qualitative data did reveal improved feelings of physical health and wellbeing.
Conclusions
The intervention improved several aspects of fitness in older adults and improved the participants’ perceptions of their own physical abilities and wellbeing. While most participants found the online intervention enjoyable, several participants missed the feedback from the instructors that naturally occurs with in-person instruction. Future studies using a randomized controlled design are needed to further establish the efficacy of online dance training on health outcomes in older adults.
Impact of AI Virtual Standardized Patients (AI-VSP) on performance in a Clinical Skills Examination
Authors: Liu Alan , Martin Scott , Belousov Maksim , Fung Cha Chi , Ben-Ari Ron , May Win 
Published: November 2023

Abstract
Background: The importance of deliberate practice and feedback to promote transfer of learning is well established. Virtual Standardized Patients (VSPs) are an emerging modality designed to more realistically simulate patient encounter sections (versus traditional e-learning), while providing automatically generated feedback to the learner. This study aims to evaluate the effectiveness of VSPs on the performance of third year medical students in a clinical skills examination.
Methods: The study was a post-test design with volunteer third-year medical students from a medical school in a large, urban, metropolitan area in Los Angeles, California. The entire class of medical students was given access to a virtual standardized patient from “Recourse AI” (AI-VSP) and their performance on subsequent clinical examinations (CSEs) was measured. A formative CSE was followed by a summative one three months later. Students were allowed to interact as many times with the AI-VSP as they desired, and received automatically generated feedback from the system. The AI-VSP presented with a chief complaint similar to that presented by a standardized patient (SP) in the clinical exams. We hypothesized that students who utilized the AI-VSP would perform better on that particular case, than those who did not. T-tests were used for statistical analysis.
Results: Students who interacted with the AI-VSP before the formative CSE achieved significantly higher scores for the History section in the first clinical examination, when presented with a SP case with a similar chief complaint (p = 0.001). Those students who interacted with an AI-VSP more than once performed better than those who interacted only once. (p = 0.005). Scores on the summative CSE three months after the interaction showed that the history scores were still slightly higher for those who had interacted at least once with AI-VSP, although there was no longer a significant difference.
Conclusions: The use of the AI-VSP showed a statistically significant improvement in history-taking skills as measured in a subsequent CSE. The improvement was not as significant in another exam three months later, underscoring the need for repetition and deliberate practice to maintain clinical skills, and maybe an estimation of the time interval required for repetition.
A Study of Engine Culture towards Dropping the Probability of Jungle Blazes
Authors: Singh Bakshish 
Published: November 2023

Abstract

Forest fire prevention is critical to protecting our natural resources and ensuring the safety of wildlife and communities. Traditional fire prevention methods have limitations in detecting and predicting fires before they cause irreparable damage. This report proposes a novel approach using machine learning to enhance forest fire prevention efforts. By leveraging machine learning algorithms and analyzing relevant data such as oxygen levels, temperature, and humidity, we can develop a predictive model to assess the probability of a fire occurring in a particular area. This model can be a valuable tool for governments and authorities to allocate resources effectively and proactively to prevent fires. The research focuses on creating a large dataset by collecting real-life examples of forest fires and their associated parameters. With this dataset, a machine learning model can be trained to accurately predict the likelihood of a fire outbreak based on the input parameters. Integrating this model into a web or mobile application can provide users with real-time fire risk assessments and alerts, enabling them to take necessary precautions. The proposed system offers a comprehensive and efficient solution for forest fire prevention, with the potential to be applied globally. By combining machine learning capabilities with preventive measures and community involvement, we can significantly reduce the negative impact of forest fires and safeguard the natural environment.
Amidst Cytokine Storm in Metabolic Diseases: Can 2-deoxy-D-glucose
(2-DG) Cure COVID-19?
Authors: Shrivastava Shweta , Kumar Ayush , Kumar Jeengar Manish , Xavier Elsy , Tiwari Prashant 
Published: November 2023

Abstract:
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)-related pandemic
disease COVID-19, which began in China in 2019, became the leading cause of fatalities globally.
The transmission rate of the virus is directly proportional to the so-called ‘dance dynamic’ energy of
the spike protein as this phenomenon favours the ligand-receptor binding. The clinical spectrum of
the COVID-19 disease, which includes (inflammation, cytokine storm, and multi-organ dysfunction),
puts Corona Warriors active in various aspects of the disease, such as the efficient management of
critically ill COVID-19 patients, in danger of losing their lives. Due to its effects on an ancient oxygen-independent glycolytic pathway, anti-inflammatory properties, and competitive interaction with
viral proteins, 2-deoxy-D-glucose (2-DG), which is being developed in India at the Defence Research and Development Organization (DRDO), has emerged as a ground-breaking agent for
COVID-19 treatment. After a virus gains entry into host cells, it is found that metabolic reprogramming takes place to meet the nutritional and energy requirements for virus reproduction. The recent
approval of 2-DG for adjunctive emergency usage by the Drug Controller General of India (DCGI)
may mark a turning point in the management of mild to moderate COVID-19 infection.
Sustainability and Management Accounting Research
Authors: Cheng Mandy M. , Perego Paolo , Soderstrom Naomi S. 
Published: November 2023

ABSTRACT
This article provides an overview of the papers accepted in the Special Interest Forum of Journal of Management Accounting Research focused on sustainability. The discussion outlines topics and contributions from the selected papers and positions them in relation to prior research and ongoing discussions in the field. Drawing on the “three-legged stool” model that captures the relationships between performance measurement system, incentives, and organizational structure/corporate governance, we suggest potential research avenues on sustainability in management accounting and related fields.
The Use of an Ambroxol Solution to Assess Acute Dermal Irritation on Rabbit Skin
Authors: Wahyuddin Munifah , Mukhriani  , Vera Olfiana  , Ika Puspita Sari  , Rizka Humardewayanti Asdie  , Titik Nuryastuti  
Published: November 2023

Ambroxol can overcome infections due to the presence of biofilms in the body by interfering with the formation of sticky biofilms and reducing biofilm production, so it has the potential to be used in topical preparations for the treatment of infections. This study aimed to measure the irritating effect on the skin of rabbits resulting from the ambroxol solution to assess the safety of the ambroxol solution. The methods refers to BPOM 2020, namely by dabbing 0.5 ml of ambroxol solution on the back skin of rabbits, then covering it with gauze and non-irritant plasters, after 4 hours of cleaning of residues is then observed at 1 , 24, 48 and 72 hours to see whether or not there was an effect of erythema and edema arising from the influence of the experiment, and at the end of the investigation, a histopathological test was carried out. The results of the research are Macroscopically the ambroxol solution did not show any erythema and edema, so the primary irritation index score was obtained for all test solutions with a score of 0. In contrast, in the microscopic irritation test, the score for erythema was 4 and for edema was 3. . From this research, it can be concluded that the ambroxol solution non-irritating to the skin.

KEYWORDS: Biofilm, ambroxol solutions, acute irritation test.
Relief and mobile veterinary careers may offer a path towards improved quality of life
Authors: Kogan Lori R. , Rishniw Mark 
Published: November 2023

Abstract

OBJECTIVE
Explore relief and mobile veterinarians’ views and experiences related to their current job. In addition, examine reasons why these veterinarians opted to pursue careers in relief and mobile practice.

SAMPLE
Veterinary members of the Veterinary Information Network working as relief or mobile veterinarians.

METHODS
An electronic survey distributed via the Veterinary Information Network data collection portal from May 11, 2023, through May 30, 2023.

RESULTS
A total of 444 responses were collected (125 veterinarians in mobile practice and 240 relief veterinarians). Factors most commonly reported to have a strong effect on mobile or relief veterinarians’ decision to leave their previous job included administration, hospital culture, leadership, feeling their voice was heard, and workplace schedule factors. The majority of mobile and relief practitioners reported feeling satisfied with their work-life balance (mobile, 78%; relief, 91%) as well as availability for children (mobile, 84%; relief, 84%) and other family members (mobile, 85%; relief, 87%).

CLINICAL RELEVANCE
The majority of mobile and relief practitioners who participated in this survey reported feeling satisfied or very satisfied with managing their work and life, in their ability to be present and available for their children, and having opportunity to support and care for elderly family members and those with medical needs. As the field of veterinary medicine becomes increasingly feminized, schedule flexibility and work-life balance will likely increase in importance, making careers in nonpractice settings more desirable. Traditional brick-and-mortar clinics should note that dissatisfaction with administration and office/hospital culture might drive their employees to pursue other career avenues such as relief or mobile practice.
Use of liposomal bupivacaine in dogs and cats undergoing gastrointestinal surgery is not associated with a higher rate of surgical site infections or multidrug-resistant infections
Authors: Andrews Camille , Williams Rachel , Burneko Marie 
Published: November 2023

Abstract

OBJECTIVE
To report the rate of surgical site infections (SSIs) after clean-contaminated and dirty gastrointestinal surgery in dogs and cats that did and did not receive incisional infiltration of Nocita and report the bacteria isolated.

ANIMALS
Client-owned dogs (n = 211) and cats (78).

METHODS
Records of dogs and cats that underwent gastrointestinal surgery at the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania and the University of Florida Small Animal Hospital between July 1, 2020, and April 1, 2023, were reviewed for surgical procedures, presence of preoperative septic peritonitis, use of Nocita, perioperative antibiotics administered, postoperative antibiotic use, SSI development postoperatively, and aerobic bacteria isolated.

RESULTS
7 of 124 (5.6%) dogs that received Nocita and 9 of 87 (10.2%) that did not receive Nocita developed an SSI. No dogs presenting with septic peritonitis and given Nocita (n = 5) developed an SSI. Two of 55 (3.6%) cats that received Nocita and 1 of 23 (4%) that did not receive Nocita developed an SSI. Multidrug-resistant (MDR) Escherichia coli was the most common aerobic bacteria isolated from SSIs (n = 3), and MDR bacteria were isolated commonly from both groups (4).

CLINICAL RELEVANCE
Use of Nocita for gastrointestinal surgery in dogs and cats is not associated with higher rates of SSI than published rates of SSI after gastrointestinal surgery. Use of Nocita in dogs with preoperative septic peritonitis is not associated with the development of SSI. MDR bacteria are commonly isolated via culture from both dogs that received Nocita and those that did not.
Association between multilingualism and cognitive performance among older adults in rural southern India
Authors: Menon Anjana Jayakumar , Malo Palash Kumar , Jain Shubham , Gandhi Sandhya , Sundarakumar Jonas S. , Rai Pooja , Issac Thomas Gregor 
Published: November 2023

Objectives:
Recent studies have shown that multilingualism may play an important role in enhancing cognitive health. The process of language acquisition constitutes a form of natural brain training, which in turn is hypothesized to increase neuroplasticity and hence, maintains the cognitive reserve. The study aimed to analyze the relationship between the number of languages known to an individual and its effect on cognitive functioning in both healthy and cognitively impaired study participants.

Materials and Methods:
This study utilized cross-sectional (baseline) data from Srinivasapura Aging, Neuro Senescence and COGnition study, which is an ongoing community-based, longitudinal aging cohort study conducted in a rural setting in southern India. A total of 3725 participants were considered for the study. The participants were separated into two groups, namely, monolinguals (participants knowing one language) and multilingual (participants knowing more than one language). The cognitive performance of the participants was assessed using the Clinical Dementia Rating (CDR) Scale. In addition, bivariate analyses and binary logistic regression analyses were carried out.

Results:
The result of CDR scores with respect to language category shows that, among the monolingual participants, 86.5% were healthy individuals and 13.5% were with mild cognitive impairment (MCI). Similarly, among the multilingual, 94.3% were healthy and 5.7% were with MCI. The odds ratio value derived from logistic regression (0.69 95% CI (0.5-0.9)) that an individual has a higher chance of developing cognitive impairment if he/she is a monolingual.

Conclusion:
This study highlights that knowing more than one language might have a profound positive impact on cognitive health, thereby reducing the likelihood of developing cognitive decline.
KAJIAN PEMANFAATAN ASAP CAIR DARI TEMPURUNG KEMIRI PADA PROSES PENGAWETAN BAKSO
Authors: Simamora Muhammad Rizky , Sulhatun Sulhatun , Suryati Suryati , Jalaluddin Jalaluddin , Kurniawan Eddy 
Published: November 2023

Tempurung kemiri diperoleh dari hasil samping dari biji kemiri yang dipisah dari isi dan bijinya. Pemanfaatan tempurung kemiri masih sangat terbatas. Kemiri biasanya digunakan sebagai rempah pangan adalah bagian bijinya saja sedangkan kulitnya dibuang begitu saja sehingga pemanfaatan limbah kulit kemiri sangat diperlukan baik sebagai solusi untuk rehabilitasi lahan kritis dan juga digunakan sebagai bahan bakar alternatif. Tempurung kemiri dapat dimanfaatkan sebagai asap cair melalui proses pirolisis. Asap cair kemudian dimanfaatkan sebagai bahan antibakteri, minyak rambut, bahan pengawet makanan, dan sebagainya. Penelitian ini sudah pernah dilakukan sebelumnya, yang belum pernah dilakukan adalah perbedaan bahan baku dalam pembuatan asap cair untuk pengawetan, yaitu tempurung kemiri. Berdasarkan hal tersebut maka dilakukan penelitian kajian pemanfaatan asap cair dari tempurung kemiri pada proses pengawetan bakso dengan variasi asap cair 2%, 4%, 6%, 8%, dan 10% dengan waktu pengawetan selama 5 hari. Pada penelitian ini diperoleh hasil pengawetan terbaik yaitu pada variasi asap cari 6% dengan tekstur bakso agak kasar dan kenyal, beraroma daging dan asap cair, berwarna putih keabu-abuan seperti bakso pada umumnya, kadar air diperoleh sebesar 69,33%, dan pH sebesar 6,8 dengan lama waktu simpan selama 2 hari hal ini sesuai dengan SNI 3818:2014.
PEMBUATAN BRIKET CANGKANG KELAPA SAWIT MENGGUNAKAN VARIASI JENIS DAN PERSENTASE PEREKAT TEPUNG TAPIOKA DAN TEPUNG BERAS
Authors: Milya Cut , Kurniawan Eddy , Hakim Lukman , Dewi Rozanna , Muhammad Muhammad 
Published: November 2023

Sumber energi alternatif yang banyak dikembangkan dan diteliti saat ini adalah bahan bakar biomassa limbah pertanian. Biomassa seperti cangkang kelapa sawit dapat menjadi sumber bahan baku briket sebagai salah satu energi alternatif pengganti bahan bakar fosil (minyak bumi). Penelitian Pembutan Briket Arang dengan Biomassa sudah pernah dilakukan oleh beberapa peneliti sebelumnya, dengan menggunakan biomassa dan jenis perekat yang berbeda, yang belum pernah dilakukan adalah Pembuatan Briket Arang dari Cangkang kelapa Sawit Menggunakan Variasi Jenis dan Persentase Perekat Tepung Tapioka dan Tepung Beras. Tujuan penelitian untuk menganalisa jenis dan persentase perekat yang tepat untuk membuat briket arang cangkang kelapa sawit agar menghasilkan briket dengan kualitas yang baik sesuai standar meliputi kadar air, kadar abu, dan nilai kalor. Proses pembuatan briket meliputi proses karbonisasi, pencampuran biomassa dengan perekat, pencetakan, pengeringan, dan uji kualitas briket yaitu kadar air, kadar abu dan nilai kalor. Hasil penelitian menunjukkan bahwa briket arang cangkang kelapa sawit sudah memenuhi standar. Pada briket perekat tepung tapioka kadar air rata-rata sebesar 2.35%, kadar abu sebesar 5.06%. Sedangkan pada briket perekat tepung beras kadar air rata-rata sebesar 2.74%, kadar abu 5.50%. Nilai kalor dari briket arang menggunakan perekat tepung tapioka dan tepung beras dengan persentase 4% masing-masing sebesar 6930.11 kal/gr dan 6922.22 kal/gr.