bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytokine profile of oral fluid in patients with food allergy associated with atopic dermatitis and psoriasis
Authors: Barilo A. A. , Smirnova S. V. , Peretyatko O. V. 
Published: February 2024

The world is experiencing a rapid increase in the prevalence of allergic and autoimmune diseases. It is known that allergic inflammation is most often systemic, involving various organs and systems in the pathological process, such as the skin, respiratory and gastrointestinal tract with the development of dermatorespiratory, dermato-intestinal and other manifestations. The study of the features of the cytokine profile in oral fluid (saliva) deserves special attention, since these characteristics reflect not only local, but also systemic disorders. Of particular relevance is the study of local cytokine regulation of intercellular interactions in food allergies. Our objective was to study the concentration of IL-4, IL-10, IFNγ, secretory IgA in salivary fluid, the concentrations of total immunoglobulin E and eosinophilic cationic protein in blood serum of the patients with atopic dermatitis and psoriasis with concomitant food allergies.The study included patients with atopic dermatitis (AD, group 1, n = 20), psoriasis with concomitant food allergy (PS, group 2, n = 27), psoriasis without concomitant allergies (PS, comparison group 3, n = 23). Quantitative assessment of the cytokine concentrations (IL-4, IL-10, IFNγ, sIgA) in salivary fluid was carried out by enzyme-linked immunosorbent assay. Concentrations of total immunoglobulin E and eosinophilic cationic protein in blood serum were determined by indirect immunofluorescence. The obtained results were processed using the Statistica 8.0 applied software.In groups of patients with atopic dermatitis (Group 1) and psoriasis with concomitant food allergy (Group 2), we have noted a statistically significant increase of salivary IL-4 and IL-10, as well as of total immunoglobulin E concentrations in blood serum as compared with a group of patients with psoriasis without concomitant allergies (group 3), and with control group. When studying concentrations of IFNγ in saliva, no statistically significant intergroup differences were found. The concentration of sIgA in saliva was significantly higher in the groups of patients with atopic dermatitis and psoriasis accompanied by food allergies in comparison with control group and the group of psoriatic patients without food allergies (group 3).The cytokine profile of saliva is characterized by unidirectional changes in food allergy. Skin seems to be the shock organ in this condition, regardless of nosological form of the disease (atopic dermatitis or psoriasis). Salivary fluid is an easily accessible material when assessing the state of mucosal immunity in food allergies.
Phenotypic features of dendritic cells when using different modes of their stimulated maturation
Authors: Fadeyev F. A. , Aleksandrova A. D. , Mogilenskikh A. S. 
Published: February 2024

Monocyte-derived dendritic cells (DCs) can be used for cell immunotherapy of cancer. In most cases, mature DCs, loaded with tumor-associated antigens, are used for immune therapy. The functionality of DCs for immunotherapy substantially depends on their immunophenotype and secretory profile, which are established after DCs maturation. The purpose of this research was to explore the phenotype of DCs after using various approaches for stimulation of their maturation.Maturation of DCs was stimulated by pro-inflammatory cytokines and their mixtures, or by ligands to the TLRs of DCs. DCs were stimulated by the following means: TNF; poly I:C; LPS; cytokine cocktail (TNF + IL-1 + IL-6 + PGE2); the cocktail mixed with poly I:C; and melanoma cells lysate. Forty-eight hours after stimulation, the expression of DCs’ receptors involved into their interaction with T cells, was evaluated by flow cytometry. Moreover, the secretion of IL-12 (activator of T cell response) and IL-10 (inhibitor of T cell response) was estimated by ELISA technique.We have shown that, following stimulation with cytokine cocktail, the DCs exhibit highest expression of receptors, which are necessary for interaction with T cells and for activation of T cell mediated immune response, i.e., antigen-presenting receptors (HLA-DR), co-stimulatory receptors (CD83, CD40, CD86), and receptors controlling the migration of DCs to lymph nodes (CCR7). Moreover, the cocktail-stimulated DCs intensively secrete both IL-12 and IL-10. The stimulatory effect of TNF and poly I:C proved to be moderate: the expression of most receptors was significantly lower than after using the cocktail; no significant differences from control (in absence of induced maturation) in IL-12 secretion were detected. LPS and melanoma cell lysate did not affect both expression of receptors and secretory profile of DCs. Addition of poly I:C to the cytokine cocktail did not affect the receptor expression, but significantly increased the secretion of both proinflammatory IL-12 and anti-inflammatory IL-10.The results of experiments demonstrate that the mixture of cytokine cocktail and poly I:C seems to be the most effective tool for stimulation of DCs maturation. However, further experiments are required to compare the functionality of DCs when using different tools for induced DC maturation.
Gastronomic Travel Exploration Based on Healthy Traditional Beverage
Authors: Suyasa I Gede Wiwin 
Published: February 2024

One beverage with a unique presentation from Yogyakarta is Wedang Uwuh. Besides the presentation and health benefits also interesting to become a gastronomy tourist attraction that is unknown by the tourist who comes to this city. This paper aims to reveal how and why the concoction of the sacred and highly respected Sultan became the drink of ordinary people and develop a gastronomic sightseeing tour, adopting a phenomenological hermeneutic of study of literature methods approach to enable the bracketing of literature phenomena, combined with informant interview to gain a blended analysis that brings a different perspective of wedang uwuh historical interpretation. To ensure attractiveness in developing the Wedang Uwuh Gastronomic sightseeing tour and present the uncovered narration behind Wedang Uwuh, we are adopting the gastronomic tourism component method. The result finding that this beverage is part of ordinary people's tradition and since the reign of Mataram Kingdom. Wedang uwuh has at least 14 medical benefits for health. It is a unique blend made by the courtiers of Sultan Agung when accompanying the great Sultan meditating in order to determine the location currently known as Imogiri. However, the other perspective there was a "pagebluk" or pandemic in the form of typhoid and plague, where such a concoction was an immune booster to fight the pandemic. With such an interesting historical background and the extraordinary benefits of this wedang uwuh, it deserves to be the main object of a gastronomic tour package
Comparative Study of Responsible Tourism Trough Pro-Poor Tourism Approach in Kali Gajahwong Tourism Village and Code Tourism Village
Authors: Nisa An Nuur Khairune , Fadin Delfyan Intan Nurmala 
Published: February 2024

This study aims to determine the comparison of community responsibility in Code Tourism Village and Kali Gajahwong Tourism Village with a pro-poor tourism (PPT) approach. The two tourist villages started as a slum riverbank area and then turned into a tourist destination. The method used is a qualitative descriptive method with data collection through observation, literature study, and in-depth interview. The results of the study showed differences in the degree of responsibility of people living in Code and Kali Gajahwong tourism villages from PPT perspective to achieve sustainable tourism. Nonetheless, the two tourist villages practice responsible tourism by prioritizing the interests of the environmental ecosystem while preserving the existence of local culture. The PPT approach reveals that there are differences in the degree of independence, the number of tourist visits, utilization of technology, and the psychological conditions of local communities when implementing tourism activities in Kali Gajah Wong and Code.
The Onset of Instability in A Magnetohydrodynamic Channel Flow through Porous Media of Casson Fluid
Authors: D. L. Shivaraj Kumar  , M. S. Basavaraj  , N. Kavitha  
Published: February 2024

A detailed study is made on the stability of linear two-dimensional disturbances of Plane Poiseuille Flow (PPF) of Casson fluid through porous media in the presence of a vertical uniform magnetic field, B0 which is extremely useful in metals, mines, and fuels industries. Using the method of normal modes, the disturbance equations are derived. The resulting eigenvalue problem is then solved by the spectral collocation method using Chebyshev-based polynomials. The critical values of the triplets ( Rec, αc, cc ) are obtained for various values of the Casson parameter, η , Hartmann number, Ha , and porous parameter, σp. The stability of the system is discussed using the neutral stability curves for each value of the parameters present in the problem. It is found that the stability regions are enlarged for small values of η and large values of the porous parameter, σp and Hartmann number, Ha. It is also observed that the stability characteristics of plane Poiseuille flow in a porous medium are remarkably different from non-porous cases. The results obtained here contribute to the contemporary efforts to better understand the stability characteristics of PPF of Casson fluid flow through porous media in the presence of a uniform transverse magnetic field.
Effects of Lavender Aqueous Extract on the Levels of Oxidative Stress Markers in the Sera and Tissues from Male Sprague–Dawley Rats with Chronic Mild Stress Induced Depression
Authors: Ghadim Mir Behrad Aghazadeh , Amir Mahmoodzadeh , Asma Neisy , Zahra Khoshde 
Published: February 2024

Background & Objective: Oxidative stress is associated with the pathology of various neuropsychiatric disorders, such as depression and anxiety. The aim of the study was to examine the impacts of the lavender aqueous extract (LAE) on the levels of oxidative stress markers in an animal model with chronic mild stress induced depression.
Materials & Methods: 36 adult male Sprague–Dawley rats were haphazardly split into 6 groups (n=6). Rats in the test groups were put through five weeks of chronic mild stress. The sucrose preference test (SPT) confirmed depressive-like behaviors in the rats. Rats in both unstressed and stressed control groups received LAE (200 or 400 mg / kg) and distilled water respectively. The specific activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (Gpx), malondialdehyde (MDA) and as well as the total content of glutathione (GSH) were examined in the serum, liver and prefrontal cortex (PFC) using colorimetric assays.
Results: The stress group experienced a significantly decreased level of GSH, SOD, GR, Gpx and CAT, and a statistically considerable augment in MDA level in in the serum, PFC and liver p<0.05. LAE at both doses significantly reversed the depression-caused oxidative stress markers in all the studied tissues. No significant difference was observed between the two used dosages of LAE.
Conclusion: LAE is able to ameliorate depression-induced pathology possibly through anti-oxidant activity.
STRUKTUR KOMUNITAS JENIS MANGROVE DI KABUPATEN TANAH LAUT PROVINSI KALIMANTAN SELATAN
Authors: Wantoro Wantoro , Syahdan Muhammad , Salim Dafiuddin 
Published: February 2024

Kabupaten Tanah Laut adalah kabupaten yang memiliki ekosistem mangrove, dimana ekosistem mangrove tersebar sepanjamg pesisir. Tujuan dari penelitian ini adalah (1) Mengetahui komposisi dan struktur tegakan; (2) Mengetahui pengelompokan jenis mangrove. Pengumpulan data dilakukan melalui pengamatan langsung (observasi) dengan menggunakan metode Transek Garis dan Plot (line transect plot) dan analisis pengelompokan menggunakan Cluster Analysis dan Geographic Information System (GIS). Hasil penelitian menemukan komposisi jenis mangrove sejati di kawasan pesisir Kabupaten Tanah Laut terdiri dari dua puluh tiga jenis yaitu Api-api (Avicennia spp.), jenis Rambai atau Pedada (Sonneratia spp.), jenis Bakau (Rhizophora spp.), jenis Dolichandrone spathacea (Buta-buta), Ceriops tagal, Tancang (Bruguiera spp.), Xylocarpus granatum (Apel laut), Lumnitzera littorea, Nypah fruticans, Intsia bijuga, Cerbara manghas , Heritiera littoralis, Jeruju., Ketapang, Pandan , Cemara, Waru. Jenis-jenis tersebut ditemukan di sepanjang pantai Kabupaten Tanah Laut dan berada pada muara sungai.
ANALISIS KLOROFIL-A DAN KELIMPAHAN FITOPLANKTON DI PERAIRAN BUNATI KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN
Authors: Yanti Novi , Rifa'i Muhammad Ahsin , Hamdani Hamdani 
Published: February 2024

Penelitian ini akan di lakasanakan pada bulan Desember sampai dengan Juni 2018 di perairan Bunati Kabupaten Tanah Bumbu. Tujuan dari penelitian ini adalah untuk mengetahui kandungan klorofil-a pada fitoplankton, mengetahui jenis dan kelimpahan fitoplankton di Perairan Bunati serta parameter lingkungan dan menganalisis hubungan antara klorofil-a dengan kelimpahan fitoplankton, nitrat dan fosfat. data sampel klorofil-a menggunakan Kemerrer Water Sampler dengan metode Sutrisyani et al (2006). Sampel Fitoplankton dianalisis dengan metode APHA (1989). Hubungan antara kandungan klorofil-a dengan kelimpahan fitoplankton, nitrat dan fosfat dianalisis menggunakan uji korelasi Pearson Product Moment (PPM). Klorofil-a di perairan Bunati berkisar antara 0,018 – 0,1532 mg/m3. Ditemukan 2 kelas fitoplankton di perairan Bunati yaitu, kelas Bacillariophyceae 97,79 % dan kelas Dinophyceae 2,21 %, dengan kelimpahan fitoplankton berkisar antara 108 – 546 ind/L. Sebaran nitrat diperairan Bunati berkiasar antara 0,1 – 1,7 mg/l sedangkan fosfat berkisar antara 0,02 – 0,09 mg/l. Terdapat hubungan antara klorofil-a dengan kelimpahan fitoplankton dengan signifikan sebesar 0,022 dan memiliki nilai positif. Selain itu terdapat hubungan antara klorofil-a dengan nitrat yang memiliki nilai signifikan sebesar 0,019. Dan hubungan yang paling kuat atau hampir sempurna dimiliki oleh hubungan klorofil-a dengan fosfat dengan nilai signifikan sebesar 0,000.
KARAKTERISTIK KUALITAS AIR PERAIRAN BUDIDAYA RUMPUT LAUT GRACILARIA SP DI MUARA PAGATAN KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN
Authors: Al Mughni Muhammad Jauhari , Rifa'i Muhammad Ahsin 
Published: February 2024

Kegiatan0budidaya0rumput0laut jenis0Gracilaria sp, 0telah0berlangsung selama 10 tahun terakhir di perairan Muara Pagatan yang merupakan salah satu desa di Kabupaten Tanah Bumbu yang terletak di Provinsi Kalimantan Selatan, namun hingga saat ini belum ada informasi ilmiah tentang kajian kualitas air yang meliputi parameter kimia dan fisika di perairan yang berhubungan dengan kelayakan usaha budidaya rumput laut. Tujuan penelitian ini adalah untuk mengetahui kondisi perairan Muara Pagatan khususnya kualitas kimia dan fisika perairan0untuk0pengembangan0usaha budidaya0rumput0laut. Penentuan titik lokasi kegiatan pengambilan sampel menggunakan metode purposive sampling. Analisa kualitas air meliputi parameter kimia, yaitu DO, pH, salinitas, suhu, dan kecerahan, Parameter fisika, yaitu kedalaman, gelombang, arus, dan angin. Hasil penelitian menunjukkan bahwa karakteristik kualitas air di kawasan budidaya rumput laut Gracilaria sp. di Muara Pagatan di peroleh nilai parameter kimiawi, yaitu DO 7,4 – 10 mg/l; pH 7,8 – 8,2 mg/l; salinitas 30 – 39 ppt; suhu 29 - 34°C; kecerahan 1 - 2.5 m. Parameter fisik, yaitu kedalaman 2,5 – 4,5 m; gelombang 3 - 22 cm; dan arus 0,2 – 0,23 m/det. Simpulan penelitian ini adalah kualitas air perairan kawasan budidaya rumput laut di Muara Pagatan berada pada kisaran yang sesuai bagi kehidupan pertumbuhan rumput laut Gracilaria sp.
DISTRIBUSI UNSUR HARA SUBSTRAT DAN AIR PADA STRUKTUR VEGETASI MANGROVE DI DESA SUNGAI DUA LAUT KECAMATAN SUNGAI LOBAN KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN
Authors: Sari Mirna , Syahdan Muhammad , Lestarina Putri Mudhlika 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui struktur vegetasi mangrove, kandungan unsur hara (N,P, NO3-dan PO43-) di Desa Sungai Dua Laut, bagaimana hubungannya vegetasi mangrove dengan unsur hara (N,P, NO3- dan PO43-). Pengambilan dan pengukuran data dilakukan secara eksitu dan insitu yang dilakukan di Laboratorium untuk menganalisis pH tanah, N,P, NO3- dan PO43- dan secara langsung di lokasi untuk pengambilan sampling parameter kualitas air yaitu Do, pH, salinitas dan suhu. Selanjutnya dilakukan analisis data menggunakan Kolerasi Pearson dengan aplikasi SPSS V 20. Hasil penelitian menunjukkan terdapat 4 jenis mangrove yaitu Avicennia marina, Sonnerati alba, Rhizophora apiculata dan Sonnetaria ovata Vegetasi mangrove tertinggi pada tingkat pohon terdapat di muara/alami jenis Avicennia marina terendah pada jenis Rhizophora apiculata, pada anakan dan semai didominasi jenis Avicennia marina dan Sonneratia ovata. Unsur hara (N,P. NO3- dan PO43-) di dapatkan nitrat (NO3-) yang tertinggi yaitu (0,01 mg/l) distasiun muara/alami, kandungan nitrogen (N) yaitu 0,42 % pada stasiun rehabilitasi fosfat (PO43-) sebesar 0,46 mg/l pada stasiun dekat pemukiman dengan fosfor (P) yaitu 37,12 mg/100g terdapat pada stasiun muara/alami. Hubungan kolerasi unsur hara dengan mangrove tingkat pohon, anakan dan semai katagori hubungan sangat lemah sampai sangat kuat dengan p hitung tidak pengaruh terhadap N,P, NO3-dan PO43-. Hubungan frekuensi pohon dan anakan terhadap fosfor mendapatkan pengaruh signifikan antara x mangrove dengan y N,P, NO3-dan PO43- dan t hitung substrat dan air mendapatkan perbedaan yang sangat nyata (highly significance).
KEANEKARAGAMAN DAN KELIMPAHAN IKAN KARANG DI PERAIRAN DESA SUNGAI DUA LAUT KABUPATEN TANAH BUMBU KALIMANTAN SELATAN
Authors: Karim Muhammad Fatahul , Rifa'i Muhammad Ahsin , Hamdani Hamdani 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui jenis ikan dan kelimpahan ikan karang, mengetahui indeks keanekaragaman dan kelimpahan ikan karang, mengetahui hubungan kelimpahan ikan karang dengan niliai kualitas air seperti suhu, kedalaman, kecerahan, pH dan salintas. Penelitian dilakukan di daerah Perairan Desa Sungai Dua Laut Kecamatan Sungai Loban Kabupaten Tanah Bumbu Provinsi Kalimantan Selatan yaitu pada lokasi Karang Katoang, Karang Penyulingan dan Karang Mangkok.. Pengambilan data ikan karang menggunakan metode sensus visual atau visual census technique (VCT) – belt transect dengan cara menyelam (diving) maupun berenang di permukaan (snorkeling) di lokasi terumbu karang dan membentang roll meter 70 meter dengan interval 5 meter setiap 20 meter, kemudian 2,5 meter kekiri dan kanan sehingga luas 300 m2. Pengukuran parameter lingkungan dilakukan secara insitu dilokasi penelitian. Faktor yang dapat mempengaruhi kehidupan ikan karang seperti suhu, kedalaman, kecerahan, pH dan salinitas. Hasil penelitian menunjukkan ditemukan 8 jenis ikan karang yang termasuk 5 famili yaitu famili Apoginidae (Cheilodipterus isistigmus), famili Pempheridae (Pempherie vanicolensis), famili Pomacentridae (Abudefduf septemfasciatus, Hemiglyphidodo plagiometopon, Neopomacentrus anabatoides), famili Serranidae (Epinephelus merra), dan famili Chaetodontidae (Chelmon rostratus, Chaetodon octofasciatus). Kelimpahan ikan karang tertinggi yaitu dengan nilai 84 ind/300 m2 dan terendah yaitu dengan nilai 38 ind/300 m2. Untuk kelimpahan berdasarkan kelompok yang tertingg yaitu kelmpok mayor dengan nilai 31-78 ind/300 m2 dan terendah kelompok target dengan nilai 3 ind/300 m2. Selanjutnya kelimpahan berdasarkan famili yang tertinggi yaitu famili Pomacentridae dengan nilai 62 ind/300m2 dan yang terendah yaitu famili Serranidae dengan nilai 3 ind/300 m2. Sedangkan kenanekaragaman ikan karang yang tertinggi yaitu dengan nilai 1,54 dan yang terendah dengan nilai 1,17. Hubungan korelasi kelimpahan ikan karang dengan faktor pembatas seperti suhu sebesar 0,131 hubungan lemah, kedalaman dan kecerahan 0,958 hubungan mendekati sempurna, pH dan salinitan 0,585 hubungan kuat sehingga hubungan kelimpahan ikan karang dengan faktor pembatas termasuk dalam tingkat hubungan positif sedang (searah), hubungan positif mendekati sempurna (searah) dan hubungan positif sangat kuat (searah).
STRUKTUR KOMUNITAS MAKROZOOBENTHOS PADA EKOSISTEM MANGROVE DESA PAGATAN BESAR KECAMATAN TAKISUNG KABUPATEN TANAH LAUT KALIMANTAN SELATAN
Authors: Keliat Siska Adelia , Tony Frans , Lestarina Putri Mudhlika 
Published: February 2024

Manfaat penelitian ini untuk memahami struktur komunitas makrozoobenthos dan hubungannya dengan kualitas perairan dan mangrove di Desa Pagatan Besar. Penentuan stasiun pengamatan dengan metode purposive sampling. Penelitian pada makrozoobenthos dilakukan di dalam transek pengamatan vegetasi mangrove 10 m × 10 m. Hasil penelitian menunjukkan bahwa makrozoobenthos yang ditemukan terdiri dari 12 jenis yaitu Polymesoda bengalensis, Uca lactea annulipes, Scylla serrata, Episesarma, Chicoreus capucinus, Cerithidea quoyii, Cassidula aurisfelis, Telescopium Telescopium, Ellobium aurisjudae, Calliostoma zizyphinum, Nerita lineata dan Littoraria scabra. Indeks kepadatan makrozoobenthos dari ketiga stasiun menghasilkan nilai yang variatif. Indeks keanekaragaman ketiga stasiun tergolong dalam kategori keanekaragaman sedang (H’ 1 < H’ < 3,322). Indeks keseragaman Stasiun 2 dan 3 termasuk dalam kategori keseragaman tinggi (0,6 ≤ E ≤ 1,0) dan Stasiun 1 termasuk dalam kategori keseragaman sedang (0,4 ≤ E < 0,6). Nilai indeks dominansi ketiga stasiun menunjukkan bahwa ada jenis gastropoda yang mendominansi dalam masing-masing stasiun karena nilai D > 0,5. Hasil analisis korelasi sederhana “Pearson Product Moment” antara kerapatan mangrove dengan kepadatan makrozoobenthos menghasilkan hubungan yang cukup lemah dengan kerapatan mangrove dimana persamaan tersebut menunjukan nilai negative (-)
Cloud Computing Transformed IT Organizations With Its On-Demand Model, Notably Infrastructure as a Service (IaaS). Cloud Providers Manage Extensive Physical Devices, Consuming Substantial Energy and Bandwidth for Data Traffic During Virtual Machine D
Authors: Biru Ketema Deresa 
Published: February 2024

Cloud computing transformed IT organizations
with its on-demand model, notably Infrastructure
as a Service (IaaS). Cloud providers manage
extensive physical devices, consuming
substantial energy and bandwidth for data traffic
during virtual machine deployment. Balancing
energy and bandwidth are critical. This thesis
presents BOHGOA integrated with ACO to
optimize virtual machine placement in clouds,
simultaneously considering bandwidth and
energy. It yields Pareto-optimal solutions for this
trade-off. Using CloudSim, BOHGOA
outperformed GA, ACO, and FFD algorithms,
reducing bandwidth consumption by 54.14%,
32.11%, 57.47% (240 VMs) and 38.12%,
22.76%, 47.05% (500 VMs) respectively.
Additionally, it decreased physical machine
energy usage by 37.70%, 34.01%, 40.14% (240
VMs) and 27.50%, 22.28%, 30.52% (500 VMs)
respectively. These results underscore
BOHGOA&#039;s effectiveness in optimizing cloud
VM placement.