bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Pendukung Pelaksanaan Peremajaan Kelapa Sawit di Provinsi Jambi
Authors: Wulandari Siti Abir , Alamsyah Zulkifli , Napitupulu Dompak , Novra Ardi 
Published: December 2023

Efforts to accelerate oil palm replanting in Jambi Province are constrained due to internal and external factors that greatly affect oil palm farmers. The total area of oil palm plantation in 2022 in Jambi Province is 1,099,191 ha consisting of 201,835 ha of immature plants, 759,455 ha of yielding crops and 137,902 ha of damaged or old plants. Oil palm replanting needs to be done considering to the age of oil palm which has got unproductive period. Information on internal and external factors is needed to provide solutions to the obstacles faced by smallholders in oil palm replanting. These two factors influence the decision of farmers to rejuvenate their oil palm and find alternatif strategic options that can be done in order to accelerate the replanting of oil palm plantations in Jambi Province. The study design is cross sectional. The data analysis method used in this study is SWOT analysis
SAÚDE SEXUAL E SENESCÊNCIA: CONHECIMENTO SOBRE HIV/AIDS
Authors: Rosa de Oliveira Larissa , Sarralheiro Vitor Alves , Larcher Longo Priscila 
Published: December 2023

O envelhecimento está associado a mudanças sociais e físicas que fazem com que a população idosa fique mais vulnerável ao desenvolvimento de doenças crônicas e à infecção pelo vírus do HIV. A falta de conhecimento, investimento em políticas públicas mais assertivas e a invisibilidade da vida sexual ativa dessa população faz com que tenha-se um crescente número de novos casos de infecções pelo vírus do HIV em pessoas idosas. O objetivo deste estudo foi avaliar o conhecimento sobre HIV/AIDS de idosos residentes da cidade de São Paulo. O estudo é de cunho quantitativo, descritivo exploratório de delineamento transversal. Os participantes foram contactados através de uma carta convite e um formulário de forma online e não probabilística. Os instrumentos utilizados foram um questionário para caracterização da amostra e um questionário com questões estruturadas baseadas em Lazzarotto de conhecimentos sobre HIV/AIDS. Participaram deste estudo 64 idosos de ambos os sexos e os resultados revelam que existe uma defasagem em relação a conhecimentos claros sobre a forma de contaminação e tratamento do HIV/AIDS. Sugere-se que novos estudos sejam realizados, assim como, maior investimento de educação para essa população.
Scottish Gaelic Movement and Celtic Identity: An Comunn Gaidhealach at the Turn of the Twentieth Century
Authors: Reiterová Martina Vacková 
Published: December 2023

An Comunn Gaidhealach, as the main representative of the Scottish Gaelic Movement in the late nineteenth century, pursued the essential objectives of cultivating, teaching, and promoting Gaelic language, literature, music, and culture. Its members closely collaborated with their counterparts from other so-called Celtic countries, which subsequently resulted in the formation of other pan-Celtic institutions around 1900. The countries involved supported each other in achieving similar goals through common initiatives. This article explores the nature of Celtic connections through the study of the self-representation of the Gaelic language movement. It defines the most articulated topics for An Comunn Gaidhealach and identifies to what extent Celticism was part of the society’s self-representation. An Comunn Gaidhealach looked at the experience of other Celtic countries as a source of inspiration. While Celtic identity formed a negligible part of An Comunn Gaidhealach’s self-representation, a strong Celtic element was present in its discursive strategies and in the argumentation processes, both inspired by Welsh and Irish revivalist movements. The society defended Gaelic language rights, presented itself as a patron to Gaelic education, and organised the Mòd festival, all the while embracing all political and religious beliefs. The methodology of the research, inspired by Israeli sociologist Ruth Amossy, analyzes the discourse of An Deo-Gréine, the official magazine of An Comunn Gaidhealach. This perspective highlights how An Comunn Gaidhealach intended to be perceived, what discursive strategies it employed, and subsequently, how and to what extent there was a pan-Celtic aspect to its work. The results of the analysis are complemented by archival research. The conceptual framework of the study is embedded in comparative and transnational approaches to historical research. This approach is reflected in understanding the formation of collective identities from a perspective that transcends nation-states rather than focusing solely on a national context.
Bioactive, antioxidant and antimicrobial properties of chemically fingerprinted essential oils extracted from Eucalyptus globulus: in-vitro and in-silico investigations
Authors: Nasir Shah Said , Khan Ibrar , Tul Muntaha Sidra , Hayat Azam , Ur Rehman Mujaddad , Ali Shah Tawaf , Siddique Farhan , Salamatullah Ahmad Mohammad , Mekonnen Amare Bitew , Bourhia Mohammed 
Published: December 2023

Innovative approaches are urgently required to treat divestating bacterial diseases in the face of rising bacterial resistance rates. The current investigative work focused on hydro-distilling Tasmanian blue gum (Eucalyptus globulus) to isolate the essential oil, which was then tested for bioactivity, antioxidant capacity, and antibacterial activity using in-vitro and in silico assays. The antioxidant activity was avualated against DPPH and FRAP. With results of 69.63 RSA (%) (µL/L AAE) at a concentration of 5 mL/L and 51.56 (µL/L AAE) at concentration of 90 ppm in the 2,20-diphenyl-1-picryl hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays, respectively, the extracted oil indicated considerable antioxidant activity. The extracted oil demonstrated powerful antibacterial activity in in-vitro tests against both Gram-positive and Gram-negative bacterial strains, including Bordetella bronchiseptica (21 mm), Staphylococcus epidermidis (19 mm), and Staphylococcus aureus (19 mm), with significant minimal inhibitory (MIC) and minimum bactericidal (MIB) concentrations. Additionally, GC-MS analysis of the oil from E. globulus identified several low-molecular-weight compounds, including Eucalyptol, γ-Terpinene, Shisool acetate, 1,3-trans,5-cis-Octatriene, 2,6-Dimethyl-1,3,5,7-octatetraene, E,E, Cyclohexene, 1-methyl-4-(1-methylethylidene), Benzene, 1-methyl-4-(1-methylethenyl), Butanoic acid, 3-methyl-, 3-methylbutyl ester, and 1,3,8-p-Menthatriene. Several other compounds were also identified, including Fenchol, 2-Methyl-trans-3a,4,7,7a-tetrahydroindane, (E,E,E)-2,4,6-Octatriene, 1,2,3,6-Tetrahydrobenzylalcohol, acetate, Alloaromadendrene, Phenol, 2-ethyl-4,5-dimethyl, Phenol, 2-methyl-5-(1-methylethyl)-, p-Cymen-7-ol, 1,5,5-Trimethyl-6-methylene-cyclohexene, 1,3-Cyclohexadiene, 1-methyl-4-(1-methylethyl)-, 2,6-Octadien-1-ol, 3,7-dimethyl-, acetate, (Z), and more. The bioactive potential of Eucalyptus globulus essential oil against 1AJ6 and 1R4U was highlighted by molecular docking analyses, suggesting its utility as a natural source of antioxidant and antibacterial compounds with the potential to replace chemical disinfectants in a variety of applications.
Candida auris infection; diagnosis, and resistance mechanism using high-throughput sequencing technology: a case report and literature review
Authors: Hong He , Ximing Yang , Jinghan Ma , Al-danakh Abdullah , Shujuan Pan , Ying Lin , Yuting Yang , Yuehong Liu , Xingwei Yao 
Published: December 2023

BackgroundCandida auris (C. auris), a recently developing fungal disease with high virulence, easy transmission, and substantial medication resistance in hospitals, poses a growing danger to human health. In 2009, the initial documentation of this disease was made when it was discovered in the ear canal of an elderly Japanese patient. Since its initial isolation, the presence of C. auris across six continents has been a cause for severe concern among medical professionals and scientists. According to recent findings, C. auris is connected with five geographically different lineages and significant rates of antifungal resistance. Furthermore, C. auris infections in healthcare settings lack appropriate treatment options and standardized strategies for prevention and control. This results in many treatment failures and hinders the elimination of C. auris in healthcare institutions. To examine the drug resistance mechanism of C. auris and to aid in clinical therapy, we provide a case of C. auris infection along with a short review of the relevant literature.Clinical presentationAn 81-year-old female with cerebral hemorrhage was admitted to the hospital and diagnosed with a urinary catheter-related C. auris. The sample was evaluated and reported in terms of culture, identification, drug sensitivity, and gene sequencing. We also evaluated the relationship between the morphology of the isolated strains and their drug resistance. Whole-genome sequencing yielded the genes ERG11-Y132F, CDR1-E709D, TAC1B-Q503E, and TAC1B-A583S; however, no additional loci included alterations of concern, according to our results. ERG11-Y132F and TAC1B-A583S are drug-resistant gene loci, whereas CDR1-E709D and TAC1B-Q503E are unidentified variants.ConclusionWe discover a C. auris case of specific a strain in an old female that has some drug-resistant genes, and some genes may be different from already reported gene sites. Gene locus, mutation, and drug resistance mechanism studies may contribute to the creation of innovative drugs and therapeutic treatments. Clinicians and microbiologists must be aware of this globally spreading yeast, which poses substantial hospital diagnostic, treatment, and infection control challenges. Future multicenter research must be performed to uncover this health threat and provide new, effective treatments.
Diagnostic value of chemiluminescence for urinary lipoarabinomannan antigen assay in active tuberculosis: insights from a retrospective study
Authors: Huang Luyi , Niu Yayan , Zhang Li , Yang Rong , Wu Meiying 
Published: December 2023

PurposeThis study aimed to assess the efficacy of chemiluminescence-based urinary lipoarabinomannan (LAM) antigen assay as a diagnostic tool for identifying active tuberculosis.MethodsA retrospective study was conducted on 166 Tuberculosis (TB), 22 Non-Tuberculous Mycobacteria (NTM), 69 Non-TB cases, and 73 healthy controls from Zhangjiagang First Peoples Hospital between July 2022 and November 2022. Clinical and laboratory data were collected, including urine samples for LAM antigen detection, sputum samples and pleural effusion for GeneXpert, TB-DNA, and culture.ResultsTB group exhibited a higher LAM positivity rate (P &lt; 0.001). CD4 count and diabetes as independent factors influencing the diagnostic accuracy of LAM. The LAM assay showed a sensitivity of 50.6% and a specificity of 95.65%. Notably, LAM’s sensitivity was superior to TB-DNA (50.60% vs. 38.16%, P &lt; 0.05). LAM’s PTB detection rate was 51.7%, superior to TB-DNA (P = 0.047). Moreover, in EPTB cases, the LAM detection rate was 42.11%, surpassing Gene Xpert (P = 0.042), as well as exceeding the detection rates of TB-DNA and sputum culture.ConclusionLAM antigen detection using chemiluminescence has demonstrated outstanding clinical diagnostic value for active TB, especially in the diagnosis of extrapulmonary TB. The convenience of sample collection in this diagnostic approach allows for widespread application in the clinical diagnosis of active tuberculosis, particularly in cases of EPTB and sputum-negative patients.
Prediction of monthly average and extreme atmospheric temperatures in Zhengzhou based on artificial neural network and deep learning models
Authors: Guo Qingchun , He Zhenfang , Wang Zhaosheng 
Published: December 2023

IntroductionAtmospheric temperature affects the growth and development of plants and has an important impact on the sustainable development of forest ecological systems. Predicting atmospheric temperature is crucial for forest management planning.MethodsArtificial neural network (ANN) and deep learning models such as gate recurrent unit (GRU), long short-term memory (LSTM), convolutional neural network (CNN), CNN-GRU, and CNN-LSTM, were utilized to predict the change of monthly average and extreme atmospheric temperatures in Zhengzhou City. Average and extreme atmospheric temperature data from 1951 to 2022 were divided into training data sets (1951–2000) and prediction data sets (2001–2022), and 22 months of data were used as the model input to predict the average and extreme temperatures in the next month.Results and DiscussionThe number of neurons in the hidden layer was 14. Six different learning algorithms, along with 13 various learning functions, were trained and compared. The ANN model and deep learning models were evaluated in terms of correlation coefficient (R), root mean square error (RMSE), and mean absolute error (MAE), and good results were obtained. Bayesian regularization (trainbr) in the ANN model was the best performing algorithm in predicting average, minimum and maximum atmospheric temperatures compared to other algorithms in terms of R (0.9952, 0.9899, and 0.9721), and showed the lowest error values for RMSE (0.9432, 1.4034, and 2.0505), and MAE (0.7204, 1.0787, and 1.6224). The CNN-LSTM model showed the best performance. This CNN-LSTM method had good generalization ability and could be used to forecast average and extreme atmospheric temperature in other areas. Future climate changes were projected using the CNN-LSTM model. The average atmospheric temperature, minimum atmospheric temperature, and maximum atmospheric temperature in 2030 were predicted to be 17.23 °C, −5.06 °C, and 42.44 °C, whereas those in 2040 were predicted to be 17.36 °C, −3.74 °C, and 42.68 °C, respectively. These results suggest that the climate is projected to continue warming in the future.
HER2 positivity predicts BCG unresponsiveness and adaptive immune cell exhaustion in EORTC risk-stratified cohort of bladder cancer
Authors: Nam Wook , Chae Han Kyu , Jung Yeonuk , Kang Homin , Park Myungchan , Choi Ahnryul , Park Jong Yeon , Eom Dae-Woon , Kim Sung Jin 
Published: December 2023

IntroductionPredicting the response to Bacillus Calmette–Guérin (BCG) therapy in high-risk patients with non-muscle invasive bladder cancer (NMIBC) is crucial, as failure may necessitate interventions, such as radical cystectomy or salvage therapy. With the recent classification of genetic class 2a (which has HER2 protein abundance as its signature mutation of ERBB2), evaluating its prognostic role and relationship with BCG response could yield important results.MethodsThis retrospective study included 160 patients with NMIBC who underwent transurethral resection of bladder tumors at Gangneung Asan Hospital between 2000 and 2013 and were stratified based on the European Organization for Research and Treatment of Cancer (EORTC) risk criteria. In addition, we analyzed a subset of 67 patients who had received BCG induction therapy to identify factors predictive of BCG treatment response. Univariate and multivariate analyses were used to assess the impact of clinicopathological factors, HER2 positivity, and EORTC risk on recurrence, progression, survival, and BCG response. Each variable’s prognostic significance was determined using the Kaplan–Meier analysis. The tumor microenvironments (TMEs) were evaluated in relation to HER2 and EORTC risk.ResultsPatients with HER2+ had a higher median age, a greater prevalence of high-grade tumors, and more frequent recurrences. The univariate analysis demonstrated that the HER2+, intermediate (vs. low-risk) high (vs. low-risk), and EORTC recurrence risk groups were significantly associated with recurrence. In patients treated with BCG, only the HER2+ status predicted recurrence. In the univariate analysis for progression, age, high EORTC progression risk (vs. low-to-intermediate), HER2+, and programmed death-ligand 1 positive (PD-L1+) were significant factors. In multivariate analyses for progression, age, high EORTC progression risk, and PD-L1+ were significant factors for progression. HER2 expression was associated with the TME, influencing the proportion of PD-L1+ cells, as well as other markers of PD-1, CD8, and Ki67.ConclusionThe HER2+ status may be related to genetic characteristics that appear more frequently in older age, which suggests a potential for predicting the recurrence and response to BCG treatment. Additionally, analyzing TME trends of aggressive adaptive immune response characterized by HER2 expression provides insight into recurrence and BCG response mechanisms.
Patients’ perspectives on prescription cannabinoid therapies: a cross-sectional, exploratory, anonymous, one-time web-based survey among German patients
Authors: Fischer Jan Moritz , Kandil Farid I. , Katsarova Ekaterina , Zager Laura Sophie , Jeitler Michael , Kugler Felix , Fitzner Franziska , Murthy Vijayendra , Hanslian Etienne , Wendelmuth Christoph , Michalsen Andreas , Karst Matthias , Kessler Christian S. 
Published: December 2023

IntroductionSince cannabinoids were partially legalized as prescription medicines in Germany in 2017, they are mostly used when conventional therapies do not suffice. Ambiguities remain regarding use, benefits and risks. This web-based survey explored the perspectives of patients whose experiences are not well enough known to date.MethodsIn an anonymous, exploratory, cross-sectional, one-time web-based observational study, participants receiving cannabinoid therapy on prescription documented aspects of their medical history, diagnoses, attitudes toward cannabinoids, physical symptoms, and emotional states. Participants completed the questionnaires twice here: first regarding the time of the survey and then, retrospectively, for the time before their cannabinoid therapy. Participants were recruited in a stratified manner in three German federal states.ResultsN = 216 participants (48.1% female, aged 51.8 ± 14.0) completed the survey, most of which (72%, n = 155) reported pain as their main reason for cannabinoid therapy. When comparing the current state with the retrospectively assessed state, participants reported greater satisfaction with their overall medical therapy (TSQM II: +47.9 ± 36.5, p &lt; 0.001); improved well-being (WHO-5: +7.8 ± 5.9, p &lt; 0.001) and fewer problems in PROMIS subscales (all p &lt; 0.001). Patients suffering primarily from pain (72%, n = 155) reported a reduction of daily pain (NRS: −3.2 ± 2.0, p &lt; 0.001), while participants suffering mainly from spasticity (8%, n = 17) stated decreased muscle spasticity (MSSS: −1.5 ± 0.6, p &lt; 0.001) and better physical mobility (−0.8 ± 0.8, p &lt; 0.001). Data suggests clinically relevant effects for most scores. Participants’ attitudes toward cannabinoids (on a 5-point scale) improved (+1.1 ± 1.1, p &lt; 0.001). Most patients (n = 146, 69%) did not report major difficulties with the cannabinoid prescription process, while (n = 27; 19%) had their cannabinoid therapy changed due to side effects.DiscussionMost participants experienced their therapy with cannabinoids as more effective than their previous therapy. There are extensive limitations to this cross-sectional study: the originally intended representativeness of the dataset was not reached, partly due to the SARS-CoV-2 pandemic; the sample has a larger proportion of privately insured and self-paying patients. Results does not suggest that cannabinoid patients belong to a particular clientele. Effect sizes observed for pain reduction, quality of life, social participation, and other outcomes suggest a therapeutic potential, particularly in the treatment of chronic pain.
Evaluation of tracheostomy suctioning procedure among nursing and respiratory therapy students: wearable manikin vs. standard manikin
Authors: Lumowa Kevin , Lui Kin Long , Daher Noha , Baek Caroline , Tan Laren D. , Alismail Abdullah 
Published: December 2023

IntroductionThis study aims to evaluate cognitive load (CL), emotional levels (EL), and stress levels (SL) of students when using a wearable manikin vs. a standard manikin for tracheostomy suctioning (TS).MethodsThis study was approved by the Institutional Review Board. Subjects were recruited by email. Subjects completed a baseline demographics questionnaire, then they were randomized into two groups: wearable manikin group (WMG) or standard manikin group (SMG). For the WMG, an actor simulated a patient by wearing the device. In phase I, both groups were educated on how to perform TS by video and offered hands-on practice. Then I put through a tracheostomy suctioning clinical simulation and completed a post sim-survey. In phase II, the same survey was repeated after encountering a real patient as part of their clinical rotation.ResultsA total of 30 subjects with a mean age 26.0 ± 5.5 years participated. 20 (66.7%) were respiratory care students and 10 (33.3%) were nursing students. In the WMG, the median stress level dropped significantly post phase II compared to post phase I [2(1,4) vs.3(1,5), p = 0.04]. There were no significant changes in median CL, confidence, and satisfaction levels between post phase II and post phase I (p &gt; 0.05). In the SMG, the satisfaction level increased significantly post phase II compared to post phase I [5(4,5) vs.4(2,5), p = 0.004], but there were no significant changes in CL, SL, and confidence levels between post phase I and phase II. There was no significant difference in mean EL scores over time and these changes did not differ by group. Subjects in the WMG showed a higher mean competency score than those in the SMG (85.5 ± 13.6 vs. 78.5 ± 20.8, p = 0.14, Cohen’s d = 0.4), yet not significant.ConclusionOur results showed that the WMG is beneficial in helping bridge the gap of learning TS from the sim setting to the real-world clinical setting. More studies with higher sample size and use of other CL scales that assesses the different types of CL are needed to validate our findings.
Case report: Deep vein thrombosis as the sole clinical feature of Behcet’s syndrome
Authors: Omara Abdelrahman , Alkhuboli Mohamed , Nauman Javaid , Al Nokhatha Shamma , Almarshoodi Mozah 
Published: December 2023

IntroductionBehcet’s syndrome is a rare, chronic, systemic condition often categorized within the group of vasculitides. It presents a diagnostic challenge due to its varied clinical manifestations and the absence of a definitive laboratory test. Its etiology remains unclear but may involve genetic, infectious, and environmental factors.Case presentationWe report the case of a 16-year-old male who presented with deep vein thrombosis, followed by recurrent episodes of breakthrough thrombosis, despite adequate anticoagulant therapy. The patient did not meet the International Study Group (ISG) criteria nor the International Criteria for Behcet’s syndrome (ICBD) due to the absence of characteristic features such as oral aphthous ulcers, genital ulcers, and uveitis. Later in the disease course, after ruling out other causes of breakthrough thrombosis, he tested positive for HLA-B51, an allele associated with Behcet’s syndrome, and exhibited a pathergy reaction.DiscussionThe patient’s clinical course underlines the diagnostic complexity associated with Behcet’s syndrome and highlights the importance of maintaining a broad differential diagnosis in cases of recurrent thrombosis. Although HLA-B51 testing is not routinely recommended, it played a pivotal role in our case, underscoring the value of an integrated diagnostic approach. Furthermore, this case reinforces the potential for atypical presentations of Behcet’s syndrome, necessitating vigilant clinical awareness. After establishing the diagnosis, we successfully treated the patient with immunosuppressive therapy, significantly improving his condition.