bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereoelectroencephalographic exploration and surgical outcome in Lennox–Gastaut syndrome
Authors: Cho Soomi , Makhalova Julia , Medina Villalon Samuel , Villeneuve Nathalie , Trébuchon Agnes , Krouma Manel , Scavarda Didier , Lépine Anne , Milh Mathieu , Carron Romain , Bonini Francesca , Daquin Géraldine , Aubert Sandrine , Lagarde Stanislas , Pizzo Francesca , Bartolomei Fabrice 
Published: January 2025

AbstractObjectiveLennox–Gastaut syndrome (LGS) is typically characterized by drug‐resistant epilepsy and subsequent cognitive deterioration. Surgery is a rare but viable option for the control of seizures in a subset of patients with LGS. This study aimed to describe the organization of the epileptogenic zone network (EZN) in patients with LGS using stereoelectroencephalography (SEEG) and to report the outcome of post‐SEEG treatment.MethodsA quantitative SEEG signal analysis was conducted in 14 consecutive patients with LGS, in whom a potentially localized EZN was suggested based on a comprehensive noninvasive evaluation. The EZN and the irritative zone network were identified using relevant biomarkers during ictal (epileptogenicity index and connectivity epileptogenicity index) and interictal (spikes and high‐frequency oscillations) recordings. The applied post‐SEEG treatments were assessed, including SEEG‐guided radiofrequency thermocoagulation (RF‐TC), surgery, and neurostimulation.ResultsThe seizure onset patterns showed some specificity by seizure type, with 84% of tonic seizures involving low‐voltage fast activity. The EZN of patients with LGS was often, but not always, complex and extensive, involving two or more lobes (79%) and both hemispheres (64%). The lateral neocortical structures, particularly the lateral premotor and dorsolateral prefrontal cortices, were identified as being most frequently involved in the EZN. Among the explored subcortical structures, only the pulvinar, central–lateral thalamic nucleus, and hypothalamic hamartoma belonged to the EZN. Twelve patients (86%) underwent SEEG‐guided RF‐TC, with 50% experiencing a >50% reduction in baseline seizure frequency. Four patients (29%) underwent curative surgery for significant involvement of a lesion in the EZN, and one case achieved an Engel class I outcome.SignificanceThis is the first quantitative SEEG study in patients with LGS to demonstrate the utility of SEEG in identifying patients who may benefit from surgery and to perform SEEG‐guided RF‐TC. Nevertheless, the indications for SEEG should be carefully assessed, as localized EZN is uncommon in LGS.
The talk and walk in Black families: Exploring racial socialization content and competency in the context of parental worries about racial profiling and adolescents' internalizing outcomes
Authors: Adjah Farzana T. , Christophe N. Keita , Anyiwo Nkemka , Bernard Donte L. , Jones Shawn C. T. , Anderson Riana E. , Stein Gabriela Livas , Kiang Lisa 
Published: January 2025

AbstractAlthough many parents worry that their child will be the target of racial profiling, there is a dearth of literature on how parental worries about children facing racism are linked to racial socialization (RS) practices and youth internalizing symptoms. Additionally, it is unclear how RS content relative to competency may uniquely influence whether and how parental worries influence youth internalizing outcomes. Using data from 203 Black parents (Mage = 44.099, 68% mothers) of adolescents, the current study examines the direct effects of parental worries on RS content (cultural socialization, preparation for bias, and promotion of mistrust) and competency (confidence, skills, general stress, and call to action stress) on youth internalizing outcomes, as well as whether RS content and competency indirectly links parental worries about racial profiling with youth internalizing symptoms. Parental worries were positively related to greater RS content across domains and child internalizing symptoms, but there were no indirect links. Parents' worries about racial profiling were positively associated with more call to action stress, general stress, and youth internalizing symptoms. RS confidence and general stress were associated with fewer and greater internalizing symptoms, but there were similarly no significant indirect effects. Findings speak to supporting and addressing parental stress in the context of family racial worries and child adjustment and have implications for policy efforts to dismantle racism and fund programs that support youth and caregivers in managing the ongoing consequences of this insidious stressor.
Infection by the Marine Cestode Hepatoxylon trichiuri in Returning Chinook Salmon (Oncorhynchus tshawytscha) Spawners in Patagonia: Implications for a Novel Fishery
Authors: Figueroa‐Muñoz Guillermo , Torres Patricio , Rodriguez J. Marcos , Murphy Christina A. 
Published: January 2025

ABSTRACTParasitological information may be useful for managing economically important fisheries by providing insights into population dynamics and health effects. The Chinook salmon (Oncorhynchus tshawytscha), an invasive species with high socio‐ecological importance in South America, supports recreational and incipient artisanal fisheries. In Southern Chile, the recent approval of coastal fisheries for returning Chinook salmon in some regions highlights the importance of understanding salmon foraging, habitat use, and commercial value. However, such information is lacking. Parasites have been extensively used as cost‐effective biological tags to identify fish stocks. We conducted the first parasitological examination of the marine tapeworm Hepatoxylon trichiuri larvae in returning adult Chinook salmon from the Cisnes River to assess its potential as a biological tag for returning Chinook salmon in Patagonia. Of 61 Chinook salmon from the Cisnes River, 52.46% were infected by H. trichiuri, with 1.65 ± 1.26 parasites per infected salmon (mean ± SD). Infection prevalence and intensity did not differ significantly between males and females. Infection intensity was higher in larger salmon but decreased with increasing salmon condition. Infection intensity was not significantly related to length, mass, or body condition. Infection prevalence and intensity of H. trichiuri varied spatially among Patagonian river‐basin populations of Chinook salmon, thereby supporting the use of H. trichiuri as a biological tag. Our findings provide important parasitological metrics that may enhance future management practices by informing geographic variability in foraging locations of adult salmon and their commercial value for human consumption.
Overlapping Landsat Scene Classifications and Focal Context to Identify Boreal Disturbance Mapping Uncertainty
Authors: Wu Wesley J. , Remmel Tarmo K. , Ouellette Marc 
Published: January 2025

ABSTRACTThe BorealDB dataset provides annual fire and timber harvesting disturbance classifications for Ontario that are derived from a collection of independently classified Landsat scenes. This study assesses the confidence of BorealDB classifications within overlapping scene margins since multiple classifications for common locations are available. For each focal point in BorealDB, the disturbance state of its four nearest spatial orthogonal neighbors were extracted and used to produce classification tree (CT) and random forest (RF) predictions of the focal class. Uncertainty was assessed as being greatest when predictions by neighboring locations or overlapping disturbance classes disagree with the focal class. The assessment found that identified locations of uncertainty within BorealDB varied with disturbance class, with fire having lower uncertainty than timber harvesting. With the results of the analysis, we recommend the inclusion of the analysis outputs and comparisons to supplement existing ensemble confidence attribute in BorealDB.
Temozolomide‐Promoted MGMT Transcription Contributes to Chemoresistance by Activating the ERK Signalling Pathway in Malignant Melanoma
Authors: Deng Meiyi , Ren Bingjie , Zhao Jing , Guo Xia , Yang Yuanyuan , Shi Huiling , Bian Xuyu , Wu Mengyao , Xu Caihua , Tao Min , Liang Rongrui , Li Qiang 
Published: January 2025

ABSTRACTTumour cells possess a multitude of chemoresistance mechanisms, which could plausibly contribute to the ineffectiveness of chemotherapy. O6‐methylguanine‐DNA methyltransferase (MGMT) is an important effector protein associated with Temozolomide (TMZ) resistance in various tumours. To some extent, the expression level of MGMT determines the sensitivity of cells to TMZ, but the mechanism of its expression regulation has not been fully elucidated. Cultured malignant melanoma cell lines A375 and Sk‐MEL28 were employed. A luciferase assay was used to detect the transcriptional activity of the MGMT promoter. Western blotting was used to compare the expression levels of phosphorylated ERK1/2 (P‐ERK1/2) after TMZ treatment. Immunofluorescent staining was used to detect TMZ‐induced DNA damage protein levels. The sensitivity of melanoma cells to TMZ was detected by MTT assay and animal experiments. The expression of MGMT mRNA was tested by Quantitative real‐time PCR (RT‐qPCR). Flow cytometry was used to measure the apoptosis of TMZ‐treated cells. TMZ enhanced the transcription of MGMT through activating the ERK pathway. ERK inhibitors U0126 and vemurafenib (vMF) inhibited the TMZ induced transcription of MGMT. The expression of MGMT and p‐ERK1/2 was closely related in human MM tissues. vMF increased the sensitivity of melanoma (MM) to TMZ in vitro and in vivo through downregulating MGMT and promoting the TMZ induced DNA damage in MM. TMZ‐promoted MGMT transcription contributed to instinctive chemoresistance by activating the ERK signalling pathway in malignant melanoma. Our study indicates that the use of the ERK inhibitor in combination with TMZ could potentially enhance the effectiveness of clinical treatment for malignant melanoma.
Ultrasound‐Assisted Thermal Maceration of Bordo Grape (Vitis labrusca L.): Insights of Anthocyanin Degradation Kinetics, Antioxidant Activity and Thermostability Parameters
Authors: de Almeida Micael José , Ribeiro‐Sanches Marcio Augusto , Guimarães Bianca , Lago‐Vanzela Ellen Silva , Telis‐Romero Javier 
Published: January 2025

ABSTRACTThis study assessed the degradation kinetics of monomeric anthocyanins in Bordo grape must after conventional thermal maceration (CV) and thermosonication (TS) at temperatures ranging from 20°C to 90°C. Quality analysis of the musts included measurements of soluble solids (SS), pH, titratable acidity (TA), and color (L*, a*, b*, , , and ). Kinetic parameters, including half‐life (t1/2), decimal reduction time (D), temperature coefficient (Q10), and decimal reduction temperature (z), along with thermodynamic parameters such as activation enthalpy (ΔH#), Gibbs free energy (ΔG#), and activation entropy (ΔS#), were determined. Antioxidant capacity was evaluated using ABTS, DPPH, and FRAP methods after maceration and heat treatment. TS did not significantly affect pH and TA but increased SS, resulting in a higher SS/TA ratio and greater total anthocyanin content. Color parameters indicated that TS produced a darker must. The degradation followed first‐order kinetics, with rate constants ranging from 8.18 × 10−6 to 1855.00 for TS and 8.89 × 10−6 to 2070 × 10−6 (min−1) for CV, showing significant differences. TS reduced activation energy and ΔH#, with positive ΔG# confirming the non‐spontaneous nature of degradation and lower ΔS# indicating greater molecular stability. Despite the significant differences in kinetic and thermodynamic parameters between the methods, the practical impact is minimal, suggesting that anthocyanins extracted by TS have similar thermal stability to those obtained by CV. Antioxidant tests revealed that TS initially increased antioxidant capacity due to extraction, although antioxidant activity decreased with higher temperatures. Despite this, TS must showed higher antioxidant capacity post‐thermal treatment compared to CV. These results suggest that TS is an effective method to increase the extraction of anthocyanins from Bordo grape, without negatively affecting their thermal degradation kinetics, thermodynamic, and stability parameters.
Quality of life in breast cancer survivors: An ambiguous loss perspective
Authors: Salafia Caroline , Adamsons Kari 
Published: January 2025

AbstractBreast cancer is the second most common cancer diagnosed among women in the United States. Although advances in detection and medical treatment have improved survival rates, breast cancer survivors experience physical symptoms and psychological distress that can adversely impact their quality of life. Examining the quality of life in breast cancer survivors is important as it may inform supportive services, patient‐centered care, and well‐being after treatment. Theoretical perspectives such as ambiguous loss theory can assist in understanding the factors that shape quality of life. Ambiguous loss theory, developed by Pauline Boss, refers to a loss that remains unclear, unresolved, and lacks closure. Grief theorists have acknowledged grief associated with symbolic losses, such as the loss of health status. The current article integrates empirical research and established constructs derived from ambiguous loss theory to develop a middle‐range theory focused on explaining quality of life among breast cancer survivors.
Artificial Liver Support System Improves One‐Year Prognosis of Patients With Hepatitis B Virus‐Associated Acute‐on‐Chronic Liver Failure
Authors: Lan Xiaoqin , Hong Changze , Zhang Xiaofeng , Zhou Ling , Li Yuan , Zhang Caili , Mo Xingyan , Zhou Jing , Li Beiling , Qi Tingting , He Qinjun , Luo Wenfan , Lai Qintao , Ji Yali , Xu Ying , Liu Junwei , Zhou Fuyuan , Chen Jinjun 
Published: January 2025

ABSTRACTBackground & AimsAcute‐on‐chronic liver failure (ACLF) is a complex syndrome with limited treatment options. This study aims to investigate the impact of artificial liver support system (ALSS) on the one‐year prognosis of patients with Hepatitis B virus (HBV)‐associated ACLF.MethodA retrospective study was conducted on 239 patients with HBV‐ACLF in Nanfang Hospital from January 2016 to June 2021. Patients were divided into the ALSS group (n = 103) and the Standard Medical Therapy (SMT group, n = 136). Demographic, clinical, and laboratory data were collected before the first ALSS treatment for patients in ALSS group, while baseline data were collected in SMT group. According to receiving different ALSS modes, patients in ALSS group were divided into plasma exchange (PE) group and non‐PE group.ResultThe 12‐week and 1‐year liver transplant (LT) free survival rates in the ALSS group were significantly higher than that in the SMT group (65.05% vs 52.21%, p = 0.0011; 63.11% vs. 48.53%, p = 0.0006). ALSS therapy was the independent predictive factors associated with 12‐week and 1‐year mortality (hazard ratio, HR: 0.59, p = 0.04, and HR: 0.54, p = 0.01). Comparatively more ALSS‐related complications were observed in PE group. After Propensity Score Matching, the 12‐week and 1‐year LT‐free survival rates between PE and non‐PE group were similar (88% vs. 80%, p = 0.227, 88% vs. 80%, p = 0.227).ConclusionALSS therapy is a safe and effective treatment for HBV‐ACLF. ALSS improves 1‐year prognosis of patients with HBV‐ACLF.
Depressive symptoms and heart rate variability in perinatal women: A narrative review
Authors: Unno Taeko , Okayama Hisayo 
Published: January 2025

AbstractAimThis study aims to review research on heart rate variability and psychiatric symptoms in perinatal women and explains how heart rate variability can be useful in preventing depressive symptoms in perinatal women.MethodsData were collected from PubMed, CINAHL, PsycINFO, and Google Scholar. The literature search encompassed articles published until July 2024, with the inclusion criteria targeting studies on women within 1 year postpartum, starting from the gestation period. Further, articles exploring this population that discussed the relationship between anxiety, depression, stress, and heart rate variability were selected. The exclusion criterion was studies that confirmed a correlation between stressors and heart rate variability.ResultsWe identified 36 relevant articles. The results demonstrated that, since 2022, research has been conducted using smartwatches, smartphones, and so on. The effectiveness of using heart rate variability has been confirmed, particularly in studies linking it to depression. However, some studies lacked controls during measurements. Intervention studies demonstrated the effectiveness of heart rate variability biofeedback.ConclusionsThis is the first review to investigate the relationship between psychiatric symptoms and heart rate variability in perinatal women. Understanding and using the characteristics of heart rate variability may lead to the detection of psychiatric symptoms in perinatal women and to self‐care among women.
TRIM9 Controls Growth Cone Responses to Netrin Through DCC and UNC5C
Authors: Mutalik Sampada P. , Ho Chris T. , O'Shaughnessy Ellen C. , Frasineanu Anca G. , Shah Aneri B. , Gupton Stephanie L. 
Published: January 2025

ABSTRACTThe guidance cue netrin‐1 promotes both growth cone attraction and growth cone repulsion. How netrin‐1 elicits diverse axonal responses, beyond engaging the netrin receptor DCC and UNC5 family members, remains elusive. Here, we demonstrate that murine netrin‐1 induces biphasic axonal responses in cortical neurons: Attraction at lower concentrations and repulsion at higher concentrations using both a microfluidic‐based netrin‐1 gradient and bath application of netrin‐1. We find that repulsive turning in a netrin gradient is blocked by knockdown of UNC5C, whereas attractive turning is impaired by knockdown of DCC. TRIM9 is a brain‐enriched E3 ubiquitin ligase previously shown to bind and cluster the attractive receptor DCC at the plasma membrane and regulate netrin‐dependent attractive responses. However, whether TRIM9 also regulated repulsive responses to netrin‐1 remained to be seen. In this study, we show that TRIM9 localizes and interacts with both the attractive netrin receptor DCC and the repulsive netrin receptor, UNC5C. We find that deletion of murine Trim9 alters both attractive and repulsive axon turning and changes in growth cones size in response to murine netrin‐1. TRIM9 was required for netrin‐1‐dependent changes in the surface levels of DCC and UNC5C in the growth cone during morphogenesis. We demonstrate that DCC at the membrane regulates the growth cone area and show that TRIM9 negatively regulates FAK activity in the absence of both repulsive and attractive concentrations of netrin‐1. Together, our work demonstrates that TRIM9 interacts with and regulates both DCC and UNC5C during attractive and repulsive axonal responses to netrin‐1.image
Volitional Control of Chewing Frequency Affects Food Oral Processing and Texture Perception
Authors: Khramova Daria , Vityazev Fedor V. , Zueva Natalya V. , Chistiakova Elizaveta A. , Popov Sergey 
Published: January 2025

ABSTRACTBackgroundAlthough varieties in chewing patterns are essential for the transformation of food in mouth and thereby its sensorial perception, there are few reports that show the effect of chewing frequency on food oral processing and its properties.ObjectiveThe current study tested whether consciously controlled chewing frequency influences the oral processing of habitually consumed foods and their sensory analysis.MethodChewing behaviour was analysed during the mastication of mushed potato samples by 20 participants in two separate test sessions, in which they were instructed to chew the sample in their habitual manner (free chewing test) or follow a preprogrammed video animation displayed on a screen, wich guided them to maintain a constant chewing frequency (F‐const chewing test). Electromyography recording, sensory tests and rheological analysis of bolus properties were performed.ResultsOral processing in the F‐const chewing test required longer chewing time due to the elongation of chewing cycle time, rather than an increased number of chews. The contribution of jaw muscle activity to chewing effort changed resulting in greater activity of temporalis muscle in the F‐const chewing test. During volitional control of chewing frequency, the texture perception with respect to cohesiveness, adhesiveness and moisture scoring differed from that observed in habitual chewing, despite the similar physical properties of the bolus. These variabilities resulted in higher acceptability of the food sample.ConclusionSince this study clearly shows how control of chewing frequency led to changes in oral processing of food and its sensorial properties, nutritionists can employ the findings to optimise the dietary recommendations decreasing eating rate and increasing palatability of the target products.
Morphometric Analysis and Prioritisation of the Punarbhaba‐Atrai‐Jamuna River Basins in the Northwest Bangladesh for Soil Conservation
Authors: Shoumik Baig Abdullah Al , Islam Md. Sanaul , Jat Baloch Muhammad Yousuf 
Published: January 2025

ABSTRACTMorphometric analysis plays a key role in understanding the geological and hydrological behaviour of watersheds and their prioritisation for soil conservation. The Punarbhaba‐Atrai‐Jamuna river system of northwest Bangladesh is agriculturally important, but the watersheds are frequently affected by droughts in summer and river erosion during the monsoon season. The morphological studies on this river systems are very limited, and hence, the aim of this study was to investigate the morphological characteristics of their largest basins and prioritise the studied watersheds based on erosion vulnerability using two approaches. The remote sensing tools were used to delineate and analyse the linear, areal and relief aspects of the morphometric indices of the six largest river basins of Dinajpur district as the conventional methods of determining the morphological characteristics of a basin are expensive and time‐consuming. The studied basins included the following regions—Dinajpur Sadar‐Birganj (DS‐B), Dinajpur Sadar‐Khansama (DS‐K), Chirirbandar‐Khansama (C‐K), Nawabganj‐Chirirbandar (N‐C), Birampur‐Parbatipur (B‐P) and Hakimpur‐Parbatipur (H‐P). The results of the bifurcation ratio, length of overland flow, drainage density, drainage texture and constant channel maintenance indicated that the watersheds were well‐dissected and had less flood and erosion risk. The values of form factor, elongation ratio, circularity ratio and compactness coefficient dictated an elongated shape of all the basins with a mature geological adjustment. The multi‐criteria prioritisation, combining morphometric analysis with land use factors, offers a holistic understanding of watershed vulnerability signifying DS‐B and N‐C the most vulnerable watersheds, which require a sustainable development decision making framework for their management. This research also provides the brief morphological features of the three complex river system to design management practices for conservation and open a dimension for future research on the application of soil erosion models to estimate soil loss.