bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and potential efficacy of a family‐based intervention on promoting physical activity levels and fundamental movement skills in preschoolers: A cluster randomised controlled trial
Authors: He Qing , Ha Amy S. C. , Zheng Binbin , Okely Anthony D. 
Published: January 2024

AbstractPhysical activity (PA) is crucial for preschool‐aged children's health and development. However, limited evidence exists regarding the feasibility of implementing home‐based interventions and how program components influence parent cognitions and practices and child PA. This study evaluated the feasibility and potential efficacy of a family‐based PA intervention on objectively measured PA, fundamental movement skills (FMS), parental efficacy, support, goal setting and parent–child co‐activity. Guided by social cognitive theory, an 8‐week cluster randomised controlled trial was conducted in Hong Kong. The trial included parental workshops, FMS training, PA homework, social media activity sharing and exercise equipment provision. Data were collected at baseline (Time 1; April 2019) and at the end of the intervention period (Time 2; approximately 2 months later) from 108 parent–child pairs in five preschools. The intervention led to increased moderate‐to‐vigorous PA and FMS in children, along with improved parental self‐efficacy, goal setting, supportiveness and co‐participation. However, parental PA did not show significant changes. Parents expressed high satisfaction, supporting the need for tailoring interventions to address the unique needs and preferences of young children and their parents. Reinforcing the parental role and providing informative materials and training can promote healthy lifestyles in early childhood.
Immune outcomes of lung transplant recipients with different cytochrome P450 3A5 phenotypes after discontinuation of voriconazole antifungal prophylaxis
Authors: Tu Zoe H. , Pierce Brett J. , Pasley Taylor , Hutchins Aaron , Huang Howard 
Published: January 2024

AbstractIntroductionTacrolimus forms the backbone of immunosuppression regimens in lung transplant recipients (LTRs). It is extensively metabolized by cytochrome P450 (CYP) 3A5 enzymes, of which polymorphisms can significantly affect tacrolimus dose requirements. It is unknown how coadministration of tacrolimus with voriconazole, a potent CYP3A5 inhibitor, affects rejection rates or empiric dose adjustments needed after voriconazole discontinuation.MethodsThis retrospective cohort study compares LTRs with poor (PR) versus intermediate/extensive (IE) CYP3A5 metabolizer phenotypes. The primary endpoint is cumulative immune outcomes within three months of voriconazole discontinuation; secondary endpoints include change in tacrolimus dose‐to‐concentration ratios after voriconazole discontinuation.ResultsThirty‐four patients underwent full analysis: 13 IE and 21 PR metabolizers. A higher proportion of IE metabolizers were African American (46.2% vs. 9.5%, p = .03). There was no significant difference in composite immune outcomes, though there was a proportionally higher frequency of new donor‐specific antibody development in PR metabolizers (14.3% vs 7.7%, p = .56). Both groups required approximately 2.5 to 3‐fold tacrolimus dose increases post‐voriconazole discontinuation to re‐attain therapeutic levels.ConclusionThis novel investigation sheds light on how CYP3A5 phenotype could be used to guide tacrolimus dosing, with the goal of preventing both toxicity and organ rejection.
Progress in leukodystrophies with zebrafish
Authors: Shih Hung‐Yu , Raas Quentin , Bonkowsky Joshua L. 
Published: January 2024

AbstractInherited leukodystrophies are genetic disorders characterized by abnormal white matter in the central nervous system. Although individually rare, there are more than 400 distinct types of leukodystrophies with a cumulative incidence of 1 in 4500 live births. The pathophysiology of most leukodystrophies is poorly understood, there are treatments for only a few, and there is significant morbidity and mortality, suggesting a critical need for improvements in this field. A variety of animal, cell, and induced pluripotent stem cell‐derived models have been developed for leukodystrophies, but with significant limitations in all models. Many leukodystrophies lack animal models, and extant models often show no or mixed recapitulation of key phenotypes. Zebrafish (Danio rerio) have become increasingly used as disease models for studying leukodystrophies due to their early onset of disease phenotypes and conservation of molecular and neurobiological mechanisms. Here, we focus on reviewing new zebrafish disease models for leukodystrophy or models with recent progress. This includes discussion of leukodystrophy with vanishing white matter disease, X‐linked adrenoleukodystrophy, Zellweger spectrum disorders and peroxisomal disorders, PSAP deficiency, metachromatic leukodystrophy, Krabbe disease, hypomyelinating leukodystrophy‐8/4H leukodystrophy, Aicardi–Goutières syndrome, RNASET2‐deficient cystic leukoencephalopathy, hereditary diffuse leukoencephalopathy with spheroids‐1 (CSF1R‐related leukoencephalopathy), and ultra‐rare leukodystrophies. Zebrafish models offer important potentials for the leukodystrophy field, including testing of new variants in known genes; establishing causation of newly discovered genes; and early lead compound identification for therapies. There are also unrealized opportunities to use humanized zebrafish models which have been sparsely explored.
Indirect structural changes and reduced controllability after temporal lobe epilepsy resection
Authors: Janson Andrew , Sainburg Lucas , Akbarian Behnaz , Johnson Graham W. , Rogers Baxter P. , Chang Catie , Englot Dario J. , Morgan Victoria L. 
Published: January 2024

AbstractObjectiveTo understand the potential behavioral and cognitive effects of mesial temporal resection for temporal lobe epilepsy (TLE) a method is required to characterize network‐wide functional alterations caused by a discrete structural disconnection. The objective of this study was to investigate network‐wide alterations in brain dynamics of patients with TLE before and after surgical resection of the seizure focus using average regional controllability (ARC), a measure of the ability of a node to influence network dynamics.MethodsDiffusion‐weighted imaging (DWI) data were acquired in 27 patients with drug‐resistant unilateral mesial TLE who underwent selective amygdalohippocampectomy. Imaging data were acquired before and after surgery and a presurgical and postsurgical structural connectome was generated from whole‐brain tractography. Edge‐wise strength, node strength, and node ARC were compared before and after surgery. Direct and indirect edge‐wise strength changes were identified using patient‐specific simulated resections. Direct edges were defined as primary edges disconnected by the resection zone itself. Indirect edges were secondary measured edge strength changes. Changes in node strength and ARC were then related to both direct and indirect edge changes.ResultsWe found nodes with significant postsurgical changes in both node strength and ARC surrounding the resection zone (paired t tests, p < .05, Bonferroni corrected). ARC identified additional postsurgical changes in nodes outside of the resection zone within the ipsilateral occipital lobe, which were associated with indirect edge‐wise strength changes of the postsurgical network (Fisher's exact test, p < .001). These indirect edge‐wise changes were facilitated through the “hub” nodes including the thalamus, putamen, insula, and precuneus.SignificanceDiscrete network disconnection from TLE resection results in widespread structural and functional changes not predicted by disconnection alone. These can be well characterized by dynamic controllability measures such as ARC and may be useful for investigating changes in brain function that may contribute to seizure recurrence and behavioral or cognitive changes after surgery.
Academic publishing behavior and pay across business fields
Authors: Garfinkel Jon A. , Hammoudeh Mosab , Weston James 
Published: January 2024

AbstractAcademic finance faculty earn a premium relative to other business school faculty. We show that the rewards to publishing outside of the top journals (JF, JFE, RFS) are significantly lower in finance relative to a broader set of journals in other business school fields. Revealed preferences from a journal submission survey suggest these incentives influence behavior. We estimate a lower unconditional probability of a top publication in finance, which raises its marginal value, leading to higher compensation. The opportunity cost of academic finance versus industry is also larger relative to other departments. Our results complement a number of recent studies on the rise of finance industry wages and suggest a novel channel that raises the production costs of finance‐educated workers.
Bioclimatic analysis of potential worldwide production of spring‐type camelina [Camelina sativa (L.) Crantz] seeded in the spring
Authors: Weiss Ross M. , Zanetti Federica , Alberghini Barbara , Puttick Debra , Vankosky Meghan A. , Monti Andrea , Eynck Christina 
Published: January 2024

AbstractCamelina [Camelina sativa (L.) Crantz] is a Brassicaceae oilseed that is gaining interest worldwide as low‐maintenance crop for diverse biobased applications. One of the most important factors determining its productivity is climate. We conducted a bioclimate analysis in order to analyze the relationship between climatic factors and the productivity of spring‐type camelina seeded in the spring, and to identify regions of the world with potential for camelina in this scenario. Using the modelling tool CLIMEX, a bioclimatic model was developed for spring‐seeded spring‐type camelina to match distribution, reported seed yields and phenology records in North America. Distribution, yield, and phenology data from outside of North America were used as independent datasets for model validation and demonstrated that model projections agreed with published distribution records, reported spring‐seeded camelina yields, and closely predicted crop phenology in Europe, South America, and Asia. Sensitivity analysis, used to quantify the response of camelina to changes in precipitation and temperature, indicated that crop performance was more sensitive to moisture than temperature index parameters, suggesting that the yield potential of spring‐seeded camelina may be more strongly impacted by water‐limited conditions than by high temperatures. Incremental climate scenarios also revealed that spring‐seeded camelina production will exhibit yield shifts at the continental scale as temperature and precipitation deviate from current conditions. Yield data were compared with indices of climatic suitability to provide estimates of potential worldwide camelina productivity. This information was used to identify new areas where spring‐seeded camelina could be grown and areas that may permit expanded production, including eastern Europe, China, eastern Russia, Australia and New Zealand. Our model is the first to have taken a systematic approach to determine suitable regions for potential worldwide production of spring‐seeded camelina.
Persistent headache attributed to past ischemic stroke: A prospective cohort study
Authors: de Oliveira Felipe A. A. , Dourado‐Filho Mario G. , Sampaio Rocha‐Filho Pedro A. 
Published: January 2024

AbstractObjectiveTo assess the incidence, characteristics, and risk factors for developing persistent headache attributed to past ischemic stroke.BackgroundAlthough the most recent International Classification of Headache Disorders has recognized the existence of persistent headache attributed to past ischemic stroke, there has been limited research in this area.MethodsThis was a prospective cohort study. We initially assessed patients hospitalized with ischemic stroke admitted within 72 h of symptom onset. All patients underwent diffusion‐weighted magnetic resonance imaging. These patients were re‐interviewed by telephone 1 year after the stroke. Semi‐structured questionnaires, the National Institutes of Health Stroke Scale (NIHSS), and six‐item Headache Impact Test were used.ResultsA total of 119 participants answered the interview conducted 1 year after the stroke. The mean (standard deviation) age was 64 (13.1) years, 82/119 (68.9%) were female, and the median (interquartile range) NIHSS score was 2 (1.0–4.0). The incidence rate of persistent headache attributed to past ischemic stroke was 12/119 (10.1%; 95% confidence interval [CI] 5.3–17.0%). The most frequent pattern presented was a migraine‐like pattern in seven of the 12 (58.3%) patients, which had a substantial/severe impact on five of the 12 (41.7%). For most patients this headache continued, although it began to improve. Previous migraine (odds ratio 7.1, 95% CI 1.06–50.0; p = 0.043) and headache intensity in the acute phase of stroke (odds ratio 1.75, 95% CI 1.13–2.7; p = 0.012) were associated with the occurrence of persistent headache attributed to past ischemic stroke.ConclusionPersistent headache attributed to past ischemic stroke is a frequent complication after stroke. It often has a significant impact on patients’ lives and presents a migraine‐like pattern as its most frequent phenotype.
The effects of the socio‐demographic factors on judgement building in arbitration
Authors: Jafary Maziar , Carrière Jules 
Published: January 2024

AbstractThis study examines how the socio‐demographic characteristics of arbitrators and of plaintiffs affect arbitrators' judgement bases for arbitration decisions. Two research questions are tested quantitatively based on a data set of arbitration decisions in the Canadian university sector collected from the website of the Canadian Legal Information Institute. We created two models of independent variables related to the socio‐demographic characteristics of arbitrators and plaintiffs. Multinomial logistic regression is used to examine the possible impacts of these variables on the justifications used by arbitrators to explain their decisions. The results indicate that both models significantly influence how arbitrators justify their arbitral decisions. The following variables significantly contribute to the models: arbitrator's age, arbitrator's professional experience in management, plaintiff's gender, and support of the plaintiff by a collective entity (union or association). Young arbitrators are more likely to use “laws” and those who have professional experience in management tend to cite “evidence” to justify their arbitral decisions. Also, arbitrators are more likely to use “evidence” as their judgement basis for male plaintiffs who are supported by a collective entity. The details of these findings, limitations of the study, and future directions for research are further discussed.
Effects of oxygen vacancy on bond ionicity and microwave dielectric properties of YxCe1−xO2−0.5x (x = 0–0.7) ceramics
Authors: Shi Ming‐An , Wang Jia‐Ning , Xia Wang‐Suo , Yu Jin‐Zi , Wang Ying , Wu Hai‐Tao 
Published: January 2024

AbstractNovel YxCe1−xO2−0.5x (x = 0–0.7) ceramics, designed by replacing Ce4+ with Y3+, were prepared using a conventional oxide reaction. The oxygen vacancies, measured by X‐ray photoelectron spectroscopy and analyzed through the electronic structure calculated via the first‐principles method, were employed to investigate the effective valence electron charge, which plays a decisive role in calculating bond ionicity using P–V–L theory. After the substitution of Y3+ ions, the effective valence electron charge of the Ce–O bond changed because of an increase in oxygen vacancies, ultimately leading to a decrease in the Ce/Y–O bond ionicity of the YxCe1−xO2−0.5x ceramics. For microwave dielectric properties, when the YxCe1−xO2−0.5x (x = 0−0.5) ceramics were in the pure phase, porosity‐corrected permittivity and Q × f values depended on the bond ionicity, and the temperature coefficient of the resonance frequency was analyzed using the bond valence. When the YxCe1−xO2−0.5x (x = 0.6 and 0.7) ceramics were in multiple phases, the microwave dielectric properties were associated with the phase composition.
First record of the great barracuda, Sphyraena barracuda (Perciformes, Sphyraenidae), in the Azores, north‐east Atlantic
Authors: Barcelos Luís M. D. , Barreiros João B. , Barreiros João P. 
Published: January 2024

AbstractOne individual of Sphyraena barracuda was collected on August 5, 2023, in the northern coast of Terceira Island, Azores, Portugal, by spearfishing. In this note, we report this first record and discuss the occurrence, which represents the northernmost one in the north‐east Atlantic.
Diagnostic uncertainty and decision‐making in home‐based primary care: A qualitative study of antibiotic prescribing
Authors: Datta Rupak , Kiwak Eliza , Fried Terri R. , Benjamin Andrea , Iannone Lynne , Krein Sarah L. , Carter Warren , Cohen Andrew B. 
Published: January 2024

AbstractBackgroundEvaluating infection in home‐based primary care is challenging, and these challenges may impact antibiotic prescribing. A refined understanding of antibiotic decision‐making in this setting can inform strategies to promote antibiotic stewardship. This study investigated antibiotic decision‐making by exploring the perspectives of clinicians in home‐based primary care.MethodsClinicians from the Department of Veterans Affairs Home‐Based Primary Care Program were recruited. Semi‐structured interviews were conducted from June 2022 through September 2022 using a discussion guide. Transcripts were analyzed using grounded theory. The constant comparative method was used to develop a coding structure and to identify themes.ResultsTheoretical saturation was reached after 22 clinicians (physicians, n = 7; physician assistants, n = 2, advanced practice registered nurses, n = 13) from 19 programs were interviewed. Mean age was 48.5 ± 9.3 years, 91% were female, and 59% had ≥6 years of experience in home‐based primary care. Participants reported uncertainty about the diagnosis of infection due to the characteristics of homebound patients (atypical presentations of disease, presence of multiple chronic conditions, presence of cognitive impairment) and the challenges of delivering medical care in the home (limited access to diagnostic testing, suboptimal quality of microbiological specimens, barriers to establishing remote access to the electronic health record). When faced with diagnostic uncertainty about infection, participants described many factors that influenced the decision to prescribe antibiotics, including those that promoted prescribing (desire to avoid hospitalization, pressure from caregivers, unreliable plans for follow‐up) and those that inhibited prescribing (perceptions of antibiotic‐associated harms, willingness to trial non‐pharmacological interventions first, presence of caregivers who were trusted by clinicians to monitor symptoms).ConclusionsClinicians face the difficult task of balancing diagnostic uncertainty with many competing considerations during the treatment of infection in home‐based primary care. Recognizing these issues provides insight into strategies to promote antibiotic stewardship in home care settings.
Age‐dependent change and intraskeletal variability in secondary osteons of elderly Australians
Authors: Pedersen Lucille T. , Miszkiewicz Justyna , Cheah Lit Chien , Willis Anna , Domett Kate M. 
Published: January 2024

AbstractThere is a need to fully understand intra‐skeletal variability within different populations to develop and improve age‐at‐death estimation methods. This study evaluates age‐related histomorphometric changes in three different bones intra‐individually in a modern Australian sample. Four female and 13 male elderly Australian adult donors (67–93 years) were examined for osteon population density (OPD), osteon area (On.Ar), and Haversian canal area (H.Ar) of secondary osteons to compare between femora, ribs, and humeri and assess against age. In the pooled sex sample, no statistically significant correlations were observed between age and each histological variable. In the males, OPD of the femur increased significantly with age, as did porosity in the rib. In the male humeri, OPD increased moderately with age, while H.Ar was decreased moderately with age. Intra‐bone comparisons showed that males had significantly higher osteon counts in their ribs compared to their femora, while their ribs showed statistically significantly less porosity than their humeri. When bone size was accounted for, by adjusting the femur and humerus histology data by robusticity indices, histology values were found to be similar between bones within the same individual. This is despite the upper and lower limbs receiving different ranges and types of biomechanical load. Our findings demonstrate that bone size influences histomorphometry, and this could confound age‐at‐death estimations that have not been adjusted for robusticity. Future studies would benefit from examining bone histomorphometry within a larger sample size and incorporating bone robusticity measures into histology analyses.
Efficacy and safety of combined microneedling therapy for androgenic alopecia: A systematic review and meta‐analysis of randomized clinical trials
Authors: Pei Danning , Zeng Linxi , Huang Xin , Wang Bin , Liu Lu , Zhang Guoqiang 
Published: January 2024

AbstractObjectiveTo provide dermatologists with more clinical experience in treating androgenetic alopecia, we evaluated the effect and safety of combined microneedling therapy for androgenetic alopecia.MethodsStudies on combined microneedling for hair loss were comprehensively searched by us in PubMed, Excerpta Medica Database, and the Cochrane Library Database. The literature search spanned the period from 2012 to 2022. Inclusion and exclusion criteria were developed, and the literature was screened according to this criteria. The Cochrane Risk of Bias Tool was used to assess the quality of the studies. The researcher applied Revman 5.3 and Stata 15.1 software to analyze the data after extracting information from the data.ResultsFinally, 13 RCTs involving 696 AGA patients were included to compare the clinical effectiveness and adverse events of combined MN therapy with single MN therapy or single drug therapy for AGA. The results of meta‐analysis showed as follows: (1) Hair density and diameter changes: The combined MN group was significantly better than any single treatment group, and the differences were statistically significant (MD = 13.36, 95% CI = [8.55, 18.16], Z = 5.45, p < 0.00001; MD = 18.11, 95% CI = [13.70, 22.52], Z = 8.04, p < 0.00001; MD = 13.36, 95% CI = [8.55, 18.16], Z = 5.45, p < 0.00001; MD = 2.50, 95% CI = [0.99, 4.02], Z = 3.23, p = 0.001); (2) the evaluation of satisfaction for efficacy: The doctor satisfaction rating of the combined MN group was significantly higher than that of any single treatment group, with statistical difference (RR = 2.03, 95% CI = [1.62, 2.53], Z = 6.24, p < 0.00001). The difference between the two groups regarding patients satisfaction was not significant (RR = 3.44, 95% CI = [0.67, 17.59], Z = 1.49, p = 0.14). (3) Safety: There was no statistical difference in the incidence of adverse reactions between combination therapy and monotherapy (RR = 0.83, 95% CI = [0.62, 1.12], Z = 1.22, p = 0.22).ConclusionThe combined MN group showed statistically significant improvement in hair density and diameter, and good safety compared with monotherapy.