bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambientes de educativos favorecedores del proceso de enseñanza-aprendizaje
Authors: Luján Tiscareño Luis Alberto , Valdéz Burciaga Teresa Adriana , Ibarra Reyes Cecilia 
Published: January 2024

El objetivo principal de esta investigación es reconocer que en las aulas de educación superior se generan diferentes ambientes que pueden detonar o inhibir el proceso de enseñanza-aprendizaje, estos ambientes son generados en un primer momento por los docentes, quienes a través de sus prácticas, relaciones personales, propuestas y mediación, etc., pueden favorecer el ambiente de enseñanza. Por otro lado los estudiantes a través de su disposición, entrega, vocación, entre otros elementos, son factores que mejorarán el ambiente para lograr aprender a aprender. La metodología que se utilizó para analizar y propiciar ambientes de aprendizaje fue a través de la aplicación de estrategias educativas de diversos tipos a grupos del nivel superior, dichas estrategias partieron del conocimiento personal, de las inteligencias múltiples, liderazgo, la comunicación, análisis de fortalezas, oportunidades, debilidades y amenazas, lo cual llevó tanto a docentes como a estudiantes a crear a partir de las estrategias utilizadas, mejores ambientes de aprendizaje partiendo de lo personal, lo grupal, la mediación o facilitación de la asignatura y por último tomando en cuenta el aspecto físico de las aulas. Una vez que se aplicaron las estrategias se identificaron aquellos elementos ambientales que no favorecían el proceso, reconociendo aquellos factores que detonaron y favorecieron la enseñanza-aprendizaje, todo lo anterior propició cambios en las prácticas diarias y sobre todo en la disposición por parte de docentes y estudiantes para mejorar cada día aquellos factores que impactan en cambios de ambientes que propicien tanto la enseñanza como el aprendizaje provocando con esto aprendizajes significativos.
Impact of Online Eating Behavior Changes on Nutritional Status of Elementary School during Pandemic
Authors: Nurdin Muh. Ulyl Imam Fitra , Yunus Purnamaniswaty , Sari Jelita Inayah 
Published: January 2024

Introduction: COVID-19 pandemic has had a huge impact on education in Indonesia necessitating distance learning from home via online methods. Learning from home change people’s daily life including eating behavior. Children’s eating behavior plays an important role in their nutritional status.
Methods: We conducted an observational study with a cross-sectional design which included 48 subjects. Data were collected using an online structured questionnaire.
Results: The results of the relationship test show a p-value of (0.000) which is smaller than alpha (0.05). The comparison test results show a p-value of (0.000) which is smaller than (0.05).
Introduction: COVID-19 pandemic has had a huge impact on education in Indonesia necessitating distance learning from home via online methods. Learning from home change people’s daily life including eating behavior. Children’s eating behavior plays an important role in their nutritional status.
Methods: We conducted an observational study with a cross-sectional design which included 48 subjects. Data were collected using an online structured questionnaire.
Results: The results of the relationship test show a p-value of (0.000) which is smaller than alpha (0.05). The comparison test results show a p-value of (0.000) which is smaller than (0.05).
The Effect of Passive Smoking during Pregnancy on Low Birth Weight
Authors: Cahyani Nur Intan , Delim Andi Alifia Ayu , Hartoko Rahadi Arie 
Published: January 2024

Introduction: A newborn who weighs less than 2,500 grams at delivery is considered low birth weight (LBW). There are many factors that can influence the determinants of LBW. One of the multifactorial is pre-natal exposure to tobacco smoke from the partner or environment in pregnant women (passive smokers) which provides negative effects for both the mother and the fetus. This study aims to determine the relationship between passive smoking during pregnancy and LBW at RSUD H. PadjonganDg. Ngalle Takalar in 2019.
Methods: The research is an observational analysis with a case-control approach. The population in this study is all mothers who gave birth to babies in the delivery room at RSUD H. PadjonganDg. Ngalle Takalar had 139 mothers who gave birth from January to December 2019. The sampling technique in this study used purposive sampling
Results: The results showed the pregnant woman's environment who was most often exposed to cigarette smoke with LBW (<0.05), Cigarette smoke exposure in the home with LBW (<0.05), Cigarette smoke exposure in the outdoor environment with LBW (<0.05), Pregnant women who were exposed to cigarette smoke in one week with LBW(<0.05), Frequency of time pregnant women were exposed to cigarette smoke in one day with LBW(<0.05).
Conclusion: There is a significant relationship between passive smoking during pregnancy and low birth weight (LBW).
Keywords: Passive smoking; pregnancy; low birth weight
Non-royal Belamin Tradition Based on Adult Education : A Phenomenological Study of Kampong Banjar Ketapang, West Kalimantan
Authors: Wardani Nabila , Sukmawan Sony 
Published: January 2024

This research aims to explore the various roles of the non-royal belamin tradition in upholding adult education principles in Kampong Banjar, West Kalimantan. The study employed a phenomenological method with a qualitative approach. Data in this study were in the form of cultural behavior, describing the beliefs, history, and equipment of the non-royal belamin tradition from specific informants, the customary leader, and the implementer. Data were collected using interviews, observation, and documentation techniques. The analysis used an interactive model with reduction stages, data presentation, and conclusion drawing. The results revealed that the non-royal belamin tradition embodied four principles of adult education: (1) Life value-based learning, (2) Experience-based learning, (3) Topic-based learning relevant to life; (4) Problem-centered learning. Notably, the noble Islamic values demonstrated in this tradition encompass religious and social values. The values with the most profound impact on adult education in this tradition were al-ukhuwah (caring) and al-munfiqun (high awareness of helping others). Through the embodiment of these solid traditional values, harmony was consistently maintained.
Edukasi “Tuberkulosis Bukan Kutukan” Guna Menurunkan Stigmatisasi TB Ditengah Masyarakat
Authors: Zulfa Ilil Maidatuz , Handayani Widya 
Published: January 2024

Tuberculosis (TB) is an infectious disease that still be the leading cause of mortality worldwide. In Indonesia, the success treatment rate still below the standard set by WHO. One of the factors contributed to the success treatment rate is patients medication adherence while the factors affected patients medication adherence are patients knowledge, social support and public stigma. Negative stigma on patients TB could be reduced by public education and campaign. This community service was aimed to educate public in order to eliminate negative stigma on TB patients. A total of 82 participants joined the event. 63 of them had filled the stigma questionnaire. The results showed that there was an increase in number of participants who had positive perpective on TB patients. A continuous campaign and public education will reduce the stigmatitation on TB patients.
The influence of institutional characteristics on implementing school-based universal addiction prevention: a Hungarian mixed-methods nationwide study on the state of implementation, barriers, and facilitators
Authors: Árva Dorottya , Vokó Zoltán , Sápi Mária , Cselkó Zsuzsa , Rákosy Zsuzsa 
Published: January 2024

BackgroundIn Hungary, as in other European countries, substance and behavioral addictions are an increasing problem among children and adolescents. Schools play a vital role in providing the knowledge and skills needed to prevent addictions. However, various factors influence the overall effectiveness of such efforts. To design more effective preventive interventions, it is necessary to evaluate existing programs and identify possible points to intervene. Our aim was to assess the current state of addiction prevention in Hungarian schools, identify barriers, and explore facilitators that contribute to the successful implementation of addiction prevention.MethodsA nationwide cross-sectional survey-based quantitative study was performed to investigate the implementation of addiction prevention in Hungarian elementary schools (N = 2,892). With the participation of 37 teachers from 21 elementary schools, a focus group-based qualitative study was conducted to investigate teachers’ perspectives on such programs and ways to improve them.ResultsAmong the addiction topics, alcohol (61.9%), smoking (73.6%), and drug use (71.3%) were the most covered themes. Problematic use of the internet and electronic devices was addressed in 60.9% of the schools, while gaming and gambling were addressed in only 18.9%. Of schools, 55.1% reported having regular programs to support pupils’ mental health, and this differed significantly by school type and size. Logistic regression analysis revealed that the type of school, the support for teachers’ work, and the diversity of implementers were significantly associated with the quality of implementation of addiction prevention. The qualitative study showed that addiction prevention is hindered by inappropriate family or teacher models, increased workloads, and challenges in collaborating with colleagues and parents. According to the teachers, they can do the most for the health of children at school, but they need support for effective implementation.ConclusionOur results indicate the importance of school characteristics in addiction prevention implementation and call for the support and empowerment of teachers and greater organizational capacity to ensure the effectiveness of school-based addiction prevention activities. By understanding these barriers and facilitators, policymakers and educators can develop evidence-based strategies to improve the effectiveness of prevention programs.
Molecular epidemiological investigation of G6PD deficiency in Yangjiang region, western Guangdong province
Authors: Liang Hong-Feng , Cao Yan-Bin , Lin Fen , Yang Yi-Kang , Liao Yu-Wei , Ou Wei-Hao , Chen Jin-Ling , Zeng Yan-Qing , Huang Yu-Chan , Zeng Guang-Kuan , Chen Zhi-Xiao , Situ Jing-Wei , Yao Jin-Xiu , Yang Li-Ye 
Published: January 2024

Objectives: The prevalence of G6PD deficiency has not been reported in Yangjiang, a western city in Guangdong province. This study aims to investigate the molecular characteristics of G6PD deficiency in this region.Methods: Blood samples were collected from adults at a local hospital to screen for G6PD deficiency. The deficient samples were subjected to further analysis using PCR and reverse dot blot to determine the specific G6PD variants.Results: Among the 3314 male subjects, 250 cases of G6PD deficiency were found using the G6PD enzyme quantitative assay, resulting in a prevalence of 7.54% (250/3314) in the Yangjiang region. The prevalence of G6PD deficiency in females was 3.42% (176/5145). Out of the 268 cases of G6PD deficiency tested for G6PD mutations, reverse dot blot identified 20 different G6PD variants. The most common G6PD variant was c.1388G&gt;A (81/268), followed by c.1376G&gt;T (48/268), c.95A&gt;G (32/268), c.1024C&gt;T (9/268), c.392G&gt;T (7/268), and c.871G&gt;A/c.1311C&gt;T (6/268). It was observed that c.871G&gt;A was always linked to the polymorphism of c.1311C&gt;T in this population.Conclusion: This investigation into G6PD deficiency in this area is expected to significantly improve our understanding of the prevalence and molecular characterization of this condition.
Pre-lacteal feeding practice and its associated factors among mothers with children under the age of two years in Dubti town, Afar region, North East Ethiopia: a community based mixed study design
Authors: Wondmeneh Temesgen Gebeyehu 
Published: January 2024

BackgroundPre-lacteal feeding prevents the early initiation of breastfeeding and exclusive breastfeeding. It is understudied in Afar, a pastoral region in northeast Ethiopia. The study assessed the prevalence of pre-lacteal feeding practice and its associated factors among mothers with children under the age of two years in Dubti, North East Ethiopia.MethodsA community-based mixed-study design was employed. A systematic sampling technique was used to recruit 370 study participants for the quantitative study, while purposive sampling was used to select 17 study participants for the qualitative study. Logistic regression analysis was used to determine the association between independent variables and dependent variable. The results of logistic regression analysis were presented as an odd ratio with a 95% CI. A P-value &lt;0.05 was used as a cutoff point to determine statistical significance. The qualitative data were analyzed using a thematic approach.ResultsPre-lacteal feeding was practiced by 36% of mothers. Afar ethnicity (AOR = 2.5, 95% CI: 1.2–5.1), an extended family size (≥5) (AOR = 1.73, 95% CI: 1.02–2.9), a birth interval of less than 2 years (AOR = 2.77, 95% CI: 1.59–4.82), the first birth order of an indexed child (AOR = 3.87, 95% CI: 2.14–7.0), male-indexed children (AOR = 2.95, 95% CI: 1.67–5.2), and no antenatal care visits (AOR = 2.67, 95% CI: 1.67), or once or twice antenatal visits were significantly associated with pre-lacteal feeding practice. Breastfeeding counseling (AOR = 0.38, 95% CI: 0.2–0.7) and delivery at a health institution (AOR = 0.3, 95% CI: 0.17–0.55) were protective factors of pre-lacteal feeding practice. The most common pre-lacteal foods were dairy products, water, and certain plant species. Cultural beliefs are the main reason for practicing these pre-lacteal feedings.ConclusionA significant number of study participants practiced prelacteal feeding. A public health campaign emphasizing the importance of antenatal care follow-ups should be initiated. Breastfeeding counseling and delivery in a health facility should also be strengthened. Community health education about the disadvantages of pre-lacteal feeding practices should be provided to reduce traditional beliefs.
Case report: mixed large-cell neuroendocrine and hepatocellular carcinoma of the liver
Authors: Gao Xin , Wang Heng , Niu Zheyu , Liu Meng , Kong Xiaohan , Sun Hongrui , Ma Chaoqun , Zhu Huaqiang , Lu Jun , Zhou Xu 
Published: January 2024

BackgroundCases of large-cell neuroendocrine carcinoma (NEC) concomitant hepatocellular carcinoma (HCC) are very rare. Based on the microscopic characteristics, mixed HCC-NEC tumors can be divided into collision type and combined type. We report a patient with both collision and combined type HCC-NEC tumor at the same time.Case presentationA 58-year-old man with hepatitis B and cirrhosis was found to have two masses in segment 5 and segment 8 of the liver, respectively. Preoperative imaging diagnosis was primary liver cancer. Indocyanine green retention test (ICG R15) &lt;10% suggested that the patient can tolerate surgery. Partial hepatectomy was performed under the guidance of 3D reconstruction. Postoperative pathology showed that most of the tumors in S5 were large-cell neuroendocrine carcinoma (90%), and a small part were hepatocellular carcinoma (10%). The tumor in S8 of the liver was diagnosed as HCC combined with immunohistochemistry. After surgery, the patient underwent genetic testing, which indicated mutations in TP53 gene. The test of immune markers of the sample suggest that the patient may benefit little from immune checkpoint inhibitor therapy. The cisplatin and etoposide chemotherapy protocol to the patient following their surgery. Eight month later after the operation, Enhanced CT showed there was no recurrence or metastasis of the tumor.ConclusionThe case at hand augments the understanding of HCC-NEC mixed tumors, offering pivotal insights into their precise diagnosis and treatment modalities. Furthermore, we document a favorable prognosis, marked by an absence of recurrence signs thus far—a rarity in comparable instances. This enlightenment stands to facilitate the handling of ensuing cases and enhance patient prognoses.
A cohort profile of the Graham Roberts study cohort
Authors: Russell Beth , Leech Poppy , Wylie Harriet , Moss Charlotte Louise , Haire Anna , Enting Deborah , Amery Suzanne , Chatterton Kathryn , Khan Muhammad Shamim , Thurairaja Ramesh , Nair Rajesh , Malde Sachin , Smith Kate , Gillett Cheryl , Josephs Debra , Pintus Elias , Rudman Sarah , Hughes Simon , Relton Clare , Van Hemelrijck Mieke 
Published: January 2024

PurposeThe Graham Roberts Study was initiated in 2018 and is the first Trials Within Cohorts (TwiCs) study for bladder cancer. Its purpose is to provide an infrastructure for answering a breadth of research questions, including clinical, mechanistic, and supportive care centred questions for bladder cancer patients.ParticipantsAll consented patients are those aged 18 or older, able to provide signed informedconsent and have a diagnosis of new or recurrent bladder cancer. All patients are required to have completed a series of baseline questionnaires. The questionnaires are then sent out every 12 months and include information on demographics and medical history as well as questionnaires to collect information on quality of life, fatigue, depression, overall health, physical activity, and dietary habits. Clinical information such as tumor stage, grade and treatment has also been extracted for each patient.Findings to dateTo date, a total of 125 bladder cancer patients have been consented onto the study with 106 filling in the baseline questionnaire. The cohort is made up of 75% newly diagnosed bladder cancer patients and 66% non-muscle invasive bladder cancer cases. At present, there is 1-year follow-up information for 70 patients, 2-year follow-up for 57 patients, 3-year follow-up for 47 patients and 4-year follow-up for 19 patients.Future plansWe plan to continue recruiting further patients into the cohort study. Using the data collected within the study, we hope to carry out independent research studies with a focus on quality of life. We are also committed to utilizing the Roberts Study Cohort to set up and commence an intervention. The future studies and trials carried out using the Roberts Cohort have the potential to identify and develop interventions that could improve the prevention, diagnosis, and treatment of bladder cancer.
Health-related quality of life in children after surgical repair of esophageal atresia: a cross-sectional study in China
Authors: Feng Zhong , Zhu Haitao , He Weijing , Peng Xueni , Gao Runnan , Tian Yuxin , Cao Xuqing , Chen Gong , Dong Kuiran , Zheng Shan , Shen Chun 
Published: January 2024

ObjectiveTo investigate health-related quality of life (HRQOL) in patients after surgical repair for esophageal atresia (EA) and identify its potential influencing factors.MethodsA total of 102 EA children who had previously visited our hospital participated in this cross-sectional study. Basic data and disease data of the patients were collected. The HRQOL was measured with the Pediatric Quality of Life Inventory™4.0 (PedsQL™4.0) and EA-QOL questionnaire and ranked on a reverse 0–100 scale, with a higher number indicative of a better HRQOL perception. The scores of PedsQL™4.0 in children with EA were collected and compared with that of the demographically matched healthy control group. Meanwhile, the condition-specific HRQOL of EA was analyzed by the EA-QOL questionnaire, and the potential clinical factors that influenced the HRQOL were determined by the generalized linear model.ResultsThe group of EA and control reached a similar score in the generic PedsQL™4.0 (EA group: 86.55 ± 9.69; control group: 89.41 ± 6.54; p = 0.670). There was no significant difference between the EA group and the control group in other domains except the school functioning. Condition-specific HRQOL in the 2–7-year-old group had the highest score in social isolation and stress domain and the lowest score in the physical health and treatment domain, with an overall quality of life score of 83.48 ± 10.22. The scores of the 8–17-year-old group were relatively high in social relationships and health and well-being and lowest in the eating domain, with an overall quality of life score of 89.43 ± 8.57. Heart malformation, complicated esophageal surgery history, respiratory symptoms,and digestive symptoms in the past 1 month were the main factors affecting the HRQOL of children aged 2–7 years. Complicated esophageal surgery history, respiratory symptoms, and digestive symptoms in the past 1 month were the main factors affecting the HRQOL of children aged 8–17 years.ConclusionsThe findings suggest that patients with EA generally had a good HRQOL. However, EA children with postoperative complications and associated symptoms have lower scores in the EA-QOL questionnaire.
Agranulocytosis and secondary infection related to JAK inhibitors and IL-6 receptor blockers: a disproportionality analysis using the US Food and drug administration adverse event reporting system
Authors: Wei Chunyan , Yin Wanhong , Hu Tingting , Zhang Jingyi , Dan Huifang , Wu Bin 
Published: January 2024

Background: Given that the fight against coronavirus disease 2019 (COVID-19) is not over, we aimed to explore the occurrence of agranulocytosis and infectious complications in patients with and without COVID-19 following immunoregulatory therapy based on real-world data.Methods: This was a retrospective disproportionality analysis based on the US Food and Drug Administration Adverse Event Reporting System (FAERS). All cases reported between the first quarter of 2004 and the fourth quarter of 2022 about Janus kinase inhibitors (baricitinib, tofacitinib, ruxolitinib) and interleukin-6 receptor blockers (tocilizumab, sarilumab) were collected. Disproportionality analyses were conducted by reporting odds ratio (ROR) and information component (IC).Results: A total of 211,363 cases were recognized from the FDA Adverse Event Reporting System database. Data analysis showed that tocilizumab (reporting odds ratio: 3.18, 95% CI: 3.18–3.29; information component: 1.37, 95% CI: 1.31–1.42), sarilumab (ROR: 1.64, 95% CI: 1.55–1.73; IC: 0.61, 95% CI: 0.43–0.79), baricitinib (ROR: 3.42, 95% CI: 3.19–3.67; IC: 1.43, 95% CI: 1.21–1.65), tofacitinib (ROR: 2.53, 95% CI: 2.49–2.57; IC: 1.11, 95% CI: 1.05–1.16), and ruxolitinib (ROR: 1.87, 95% CI: 1.83–1.91; IC: 0.77, 95% CI: 0.70–0.84) were all associated with secondary infection. The association in the combination group was higher than that in the monotherapy group (ROR: 4.69, 95% CI: 4.53–4.86; IC: 1.73, 95% CI: 1.62–1.84). As for agranulocytosis, tocilizumab (ROR: 1.61, 95% CI: 1.53–1.69; IC: 0.67, 95% CI: 0.50–0.84) and ruxolitinib (ROR: 2.32, 95% CI: 2.21–2.43; IC: 1.18, 95% CI: 1.02–1.33) showed the significant signals. The association was higher in the combination group than in the monotherapy group (ROR: 2.36, 95% CI: 2.15–2.58; IC: 1.20, 95% CI: 0.90–1.51). Secondary infection after treatment with tofacitinib (ROR: 1.37, 95% CI: 1.02–1.84), tocilizumab (ROR: 1.46, 95% CI: 1.01–2.09), and sarilumab (ROR: 2.46, 95% CI: 1.10–5.50) was reported more frequently in COVID-19 than in non–COVID-19 patients.Conclusion: Both Janus kinase inhibitors and interleukin-6 receptor blockers are significantly associated with secondary infection and agranulocytosis, and the combined treatment further increases the association. The correlation with secondary infection in patients treated with tofacitinib, tocilizumab, and sarilumab is higher in COVID-19 than in non–COVID-19 patients.