bluuebunny/crossref_metadata_2025_split huggingface dataset:
NMDA glutamate receptor antagonist MK‐801 induces proteome changes in adult human brain slices which are partially counteracted by haloperidol and clozapine
Authors: de Almeida Valéria , Mendes Niele Dias , Zuccoli Giuliana S. , Reis‐de‐Oliveira Guilherme , Almeida Glaucia M. , Podolsky‐Gondim Guilherme Gozzoli , Neder Luciano , Martins‐de‐Souza Daniel , Sebollela Adriano 
Published: February 2024

AbstractDeciphering the molecular pathways associated with N‐methyl‐D‐aspartate receptor (NMDAr) hypofunction and its interaction with antipsychotics is necessary to advance our understanding of the basis of schizophrenia, as well as our capacity to treat this disease. In this regard, the development of human brain‐derived models that are amenable to studying the neurobiology of schizophrenia may contribute to filling the gaps left by the widely employed animal models. Here, we assessed the proteomic changes induced by the NMDA glutamate receptor antagonist MK‐801 on human brain slice cultures obtained from adult donors submitted to respective neurosurgery. Initially, we demonstrated that MK‐801 diminishes NMDA glutamate receptor signaling in human brain slices in culture. Next, using mass‐spectrometry‐based proteomics and systems biology in silico analyses, we found that MK‐801 led to alterations in proteins related to several pathways previously associated with schizophrenia pathophysiology, including ephrin, opioid, melatonin, sirtuin signaling, interleukin 8, endocannabinoid, and synaptic vesicle cycle. We also evaluated the impact of both typical and atypical antipsychotics on MK‐801‐induced proteome changes. Interestingly, the atypical antipsychotic clozapine showed a more significant capacity to counteract the protein alterations induced by NMDAr hypofunction than haloperidol. Finally, using our dataset, we identified potential modulators of the MK‐801‐induced proteome changes, which may be considered promising targets to treat NMDAr hypofunction in schizophrenia. This dataset is publicly available and may be helpful in further studies aimed at evaluating the effects of MK‐801 and antipsychotics in the human brain.
Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma
Authors: Reinecke Raphael , Jahnke Kolja , Foltyn‐Dumitru Martha , Lachner Karsten , Armbrust Moritz , Weber Katharina J. , Zeiner Pia S. , Czabanka Marcus , Brunnberg Uta , Hartmann Sylvia , Steinbach Joachim P. , Ronellenfitsch Michael W. 
Published: February 2024

AbstractFor CNS lymphomas (CNSL), there is a high need for minimally invasive and easily obtainable diagnostic markers. Intrathecal IgM synthesis can easily be determined in routine CSF diagnostics. The aim of this study was to systematically investigate the diagnostic potential of intrathecal IgM synthesis in primary and secondary CNSL (PCNSL and SCNSL). In this retrospective study, patients with a biopsy‐proven diagnosis of PCNSL or SCNSL were compared with patients with other neurological diseases in whom CNSL was initially the primary radiological differential diagnosis based on MRI. Sensitivity and specificity of intrathecal IgM synthesis were calculated using receiver operating characteristic curves. Seventy patients with CNSL were included (49 PCNSL and 21 SCNSL) and compared to 70 control patients. The sensitivity and specificity for the diagnosis of CNSL were 49% and 87%, respectively, for the entire patient population and 66% and 91% after selection for cases with tumor access to the CSF system and isolated intrathecal IgM synthesis. In cases with MRI‐based radiological suspicion of CNSL, intrathecal IgM synthesis has good specificity but limited sensitivity. Because of its low‐threshold availability, analysis of intrathecal IgM synthesis has the potential to lead to higher diagnostic accuracy, especially in resource‐limited settings, and deserves further study.image
Prioritising patients for semi‐urgent surgery: A scoping review
Authors: Coffey Elyse K. , Walker Rachel M. , Nicholson Patricia , Gillespie Brigid M. 
Published: February 2024

AbstractBackgroundSemi‐urgent surgery where surgical intervention is required within 48 h of admission and the patient is medically stable is vulnerable to scheduling delays. Given the challenges in accessing health care, there is a need for a detailed understanding of the factors that impact decisions on scheduling semi‐urgent surgeries.AimTo identify and describe the organisational, departmental and contextual factors that determine healthcare professionals' prioritising patients for semi‐urgent surgeries.MethodsWe used the Joanna Briggs Institute guidance for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis extension for scoping reviews (PRISMA‐ScR) checklist. Four online databases were used: EBSCO Academic Search Complete, EBSCO Cumulative Index to Nursing and Allied Health Literature, OVID Embase and EBSCO Medline. Articles were eligible for inclusion if they published in English and focussed on the scheduling of patients for surgery were included. Data were extracted by one author and checked by another and analysed descriptively. Findings were synthesises using the Patterns, Advances, Gaps, Evidence for practice and Research recommendations framework.ResultsTwelve articles published between 1999 and 2022 were included. The Patterns, Advances, Gaps, Evidence for practice and Research recommendations framework highlighted themes of emergency surgery scheduling and its impact on operating room utilisation. Gaps in the management of operating room utilisation and the incorporation of semi‐urgent surgeries into operating schedules were also identified. Finally, the lack of consensus on the definition of semi‐urgent surgery and the parameters used to assign surgical acuity to patients was evident.ConclusionsThis scoping review identified patterns in the scheduling methods, and involvement of key decision makers. Yet there is limited evidence about how key decision makers reach consensus on prioritising patients for semi‐urgent surgery and its impact on patient experience.Patient or Public ContributionNo Patient or Public Contribution.
The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses
Authors: Bello Kaitlyn , Lorch Gwendolen , Papich Mark G. , Kim Kyeongmin , Toribio Ramiro E. , Yan Liwei , Xie Zhiliang , Hill Kasey , Phelps Mitch A. 
Published: February 2024

AbstractAdditional immunomodulatory treatment is needed for the management of immune‐mediated disease in horses. Mycophenolate mofetil (MMF) is an immunomodulatory agent used in human and veterinary medicine for the prevention of graft rejection and the management of autoimmune diseases. Few studies exist investigating the pharmacokinetics of MMF in horses. The aim of this study was to evaluate the pharmacokinetics of a single dose of MMF in healthy horses in the fed vs. fasted state. Six healthy Standardbred mares were administered MMF 10 mg/kg by a nasogastric (NG) tube in a fed and fasted state. A six‐day washout period was performed between the two doses. No statistically significant differences in mycophenolic acid (MPA) concentrations were seen at any time point apart from 8 h, when plasma metabolite concentrations were significantly higher in the fasted state compared to the fed state (p = .038). Evidence of enterohepatic recirculation was seen only in the fasted state; this did not yield clinical differences in horses administered a single‐dose administration but may be significant in horses receiving long‐term MMF treatment.
Disentangling associations between impulsivity, compulsivity, and performance monitoring
Authors: Overmeyer Rebecca , Endrass Tanja 
Published: February 2024

AbstractDisorders marked by high levels of impulsivity and compulsivity have been linked to changes in performance monitoring, specifically the error‐related negativity (ERN). We investigated the relationship between performance monitoring and individual differences in impulsivity and compulsivity. A total of 142 participants were recruited into four groups, each with different combinations of impulsivity and compulsivity, and they performed a flanker task to assess error‐related brain activity. We defined error‐related brain activity as ERN amplitude and theta power. Single‐trial regression was employed to analyze the amplitude differences between incorrect and correct trials within the ERN time window. The findings revealed that impulsivity, compulsivity, and different measures of response processing exhibited distinct interactions, which were influenced by the configuration of impulsivity and compulsivity, but also depended on the measure of response processing. Specifically, high compulsivity predicted larger ERN amplitudes in individuals with low impulsivity, whereas high impulsivity had no significant effect on ERN amplitude in individuals with low compulsivity. Furthermore, when both impulsivity and compulsivity were high, no significant increase in ERN amplitude was observed; instead, there was a reduced difference between incorrect and correct trials. No significant differences were found for theta power. While the association between error‐related brain activity and transdiagnostic markers or psychopathology may be smaller than generally assumed, considering the interaction between different transdiagnostic markers and their facets can enhance our understanding of the complex associations that arise during the investigation of neural correlates of performance monitoring, specifically the ERN.
A Hybrid Battery Thermal Management System for Electric Vehicle Operations in Cold Climates
Authors: Jiang Yingqiao , Hashad Khaled N. , Lee Zachary E. , Zhang K. Max 
Published: February 2024

Abstract
Without proper battery thermal management, electric vehicles (EVs) suffer from significantly reduced efficiency and performance in cold climates, creating a barrier to electrifying the transportation sector. In this study, we have developed a modular, hybrid battery thermal management system that combines phase change material (PCM) with internal heating. This hybrid system uses PCM to store waste heat generated during driving, maintaining the battery temperature during shorter stops between consecutive trips. For longer stops, internal heating can reheat the battery if the latent heat of the PCM has dissipated. Moreover, by applying PCM on the outside, the proposed system is modular, requiring no structural change within the existing battery module and reducing the impact of increased thermal inertia on battery reheating time. Through both laboratory experiments and numerical simulations, we found that the proposed system could hold the battery temperature above 20 °C for around 2 h at an ambient temperature of −15 °C and achieved a battery reheating time (from 0 °C to 20 °C) of only 11 min. By reusing waste heat during short stops, this system can promote EV adoption in cold climates through improved battery efficiency, particularly for EVs making frequent stops, such as taxis and delivery vehicles.
A Hybrid Electrochemical Magnetorheological Finishing Process for Surface Enhancement of Biomedical Implants
Authors: Rajput Atul Singh , Das Manas , Kapil Sajan 
Published: February 2024

Abstract
The proposed novel polishing method, hybrid electrochemical magnetorheological (H-ECMR) finishing, combines electrochemical reactions and mechanical abrasion on the workpiece surface to reduce finishing time. Moreover, H-ECMR finishing on the biomaterial surface produces a uniform, thick passive oxide layer to improve corrosion resistance. Herein, the electrolytic solution facilitates the chemical reaction and acts as a carrier medium for carbonyl iron particles (CIPs) in magnetorheological (MR) fluid. The synergic action of the two processes reduces the surface finishing time, which takes longer in the case of the conventional magnetorheological Finishing (MRF) process, as observed experimentally. The developed H-ECMR finishing process employs an electromagnet, maneuvering in situ surface quality variation by altering the magnetic field during finishing. The magnetic shield material (i.e., mu-metal) confines the bottom of the electromagnet core to restrict the magnetic field's leakage and provide a uniform and concentrated magnetic field at the polishing spot. The effectiveness of the H-ECMR process is evaluated based on various surface roughness parameters (i.e., average surface roughness (Ra), skewness (Rsk), and kurtosis (Rku)) and compared with the MRF process. A 96.4% reduction in Ra value is attained in the H-ECMR polishing compared to 49.6% in MRF for identical polishing time. Furthermore, an analytical model is developed to evaluate the final Ra attained from the developed H-ECMR polishing process and agrees well with the experimental results. The impact of different process parameters on surface roughness values is also analyzed. The electrochemical reaction forms a thick and unvarying passive layer on the Ti–6Al–4V surface as layer thickness increases to 78 nm from 8 nm. A case study on the femoral head of the Total Hip Arthroplasty (THA) for enhancement in the surface roughness and biocompatibility is performed through the developed H-ECMR polishing. The Ra value is decreased to 21.3 nm from 326 nm on the femoral head surface through the contour-parallel radial toolpath strategy.
Effect of Acute Sodium Bicarbonate and Caffeine Coingestion on Repeated-Sprint Performance in Recreationally Trained Individuals: A Randomized Controlled Trial
Authors: Ferragut Carmen , Gonzalo-Encabo Paola , López-Samanes Álvaro , Valadés David , Pérez-López Alberto 
Published: February 2024

Introduction: The acute and isolated ingestion of sodium bicarbonate (NaHCO3) and caffeine (CAF) improves performance and delays fatigue in high-intensity tasks. However, it remains to be elucidated if the coingestion of both dietary supplements stimulates a summative ergogenic effect. This study aimed to examine the effect of the acute coingestion of NaHCO3 and CAF on repeated-sprint performance. Methods: Twenty-five trained participants (age: 23.3 [4.0] y; sex [female/male]: 12/13; body mass: 69.6 [12.5] kg) participated in a randomized, double-blind, placebo (PLA) -controlled, crossover study. Participants were assigned to 4 conditions: (1) NaHCO3 + CAF, (2) NaHCO3, (3) CAF, or (4) PLA. Thus, they ingested 0.3 g/kg of NaHCO3, 3 mg/kg of CAF, or PLA. Then, participants performed 4 Wingate tests (Wt), consisting of a 30-second all-out sprint against an individualized resisted load, interspersed by a 1.5-minute rest period between sprints. Results: Peak (Wpeak) and mean (Wmean) power output revealed a supplement and sprint interaction effect (P = .009 and P = .049, respectively). Compared with PLA, NaHCO3 + CAF and NaHCO3 increased Wpeak performance in Wt 3 (3%, P = .021) and Wt 4 (4.5%, P = .047), while NaHCO3 supplementation increased mean power performance in Wt 3 (4.2%, P = .001). In Wt 1, CAF increased Wpeak (3.2%, P = .054) and reduced time to Wpeak (−8.5%; P = .008). Plasma lactate showed a supplement plus sprint interaction (P < .001) when NaHCO3 was compared with CAF (13%, P = .031) and PLA (23%, P = .021). Conclusion: To summarize, although the isolated ingestion of CAF and NaHCO3 improved repeated-sprint performance, the coingestion of both supplements did not stimulate a synergic ergogenic effect.
Effect of an 18-Month Walking Intervention on the Rest–Activity Rhythm of Older Adults With Mild–Moderate Dementia
Authors: Volkers Karin Mariëlle , Douma Johanna Gerdine , Hoeksma Jan Binne , Scherder Erik Johan Anton 
Published: February 2024

The objective of this 18-month walking intervention was to evaluate the effect on rest–activity rhythm (RAR) for older adults with mild-to-moderate dementia (65.8% female; aged M = 82.4 [SD = 6.5]). The intervention group (n = 44) was intended to walk 30 min, five times per week for 18 months. The control group (n = 35) received sedentary activities or usual care. RAR was measured at baseline to after 18 months and five times in between actigraphy outcome variables (interdaily stability, intradaily variability, relative amplitude, activity 10 most active hours, and activity 5 least active hours). Hierarchical mixed model analyses revealed no significant intervention effects (with or without baseline confounders as covariate) on RAR. However, participants in the intervention group were able to significantly increase their daily life activity (activity 10 most active hours) from the onset of the preceding measurement, b = 0.10, t(239.32) = 2.36, p = .019. More research is warranted to study the effect of regular walks on older persons with dementia whose RAR is worst at baseline.
Quantifying Area-Level Physical Activity Offerings in Social Context: A Novel Concept That Goes Beyond Walkability and Access to Open Spaces
Authors: Merom Dafna , Meehan Drew , Phongsavan Philayrath , Gudes Ori 
Published: February 2024

Background: Social support is a crucial factor influencing the sustainability of physical activity (PA). This proof-of-concept study presents the development of a Social Physical Activity Index for Area (SPAIFA) an indicator reflecting opportunities for individuals to actively participate as part of a group within which opportunities for social interaction can be developed. Methods: Six government councils in the state of New South Wales, Australia, were selected encompassing 174 suburbs. Using 2 search engines’ map tools, we identified PA venues for each suburb (eg, park, studios, etc). To enumerate activities per suburb, we used (1) venue websites, (2) New South Wales Office of Sport website, (3) national websites of grassroots PA for nonorganized activity (eg, parkrun, meetup, etc), and (4) social media. The database was linked to the suburb demographic profile, the area disadvantage score, walkability and open space scores, and the proportion of insufficiently active residents. Spatial analysis techniques were used to identify SPAIFA clusters. Results: SPAIFA councils’ average was 9.9 activities per 10,000 people (ranging from 6.6/10,000 to 16.2/10,000). SPAIFA-Old (ie, activities specific to older adults) varied significantly (ranging from 11.7/10,000 to 0.8/10,000 seniors). Disadvantaged areas and a high proportion of insufficiently active residents were associated with being classified as low SPAIFA (P < .01). Three clusters of low SPAIFA were identified, and 17 high-risk areas where low SPAIFA was compounded by poor environmental support. Conclusions: SPAIFA can be used by councils and policymakers as an indicator for monitoring and intervening in areas where natural and/or urban design is not conducive for PA.
Preventing Suicide and Promoting Mental Health Among Student-Athletes From Diverse Backgrounds
Authors: Hamstra-Wright Karrie L. , Coumbe-Lilley John E. , Bustamante Eduardo E. 
Published: February 2024

Suicide and contributing mental health conditions in athletes are shared concerns within health care and society at large. This commentary focuses on suicide risk among athletes and the role of sports medicine professionals in preventing suicide and promoting mental health. In this commentary, we draw on the scientific literature and our clinical experiences to pose and answer these questions: Does suicide risk among athletes vary by sociodemographic factors (eg, sex, gender, race/ethnicity, family income, sexual orientation) or if injured? Do sociodemographic differences influence access to and benefits from services among athletes? How do I know my athletes are at risk for suicide? What do I do if one of my athletes shares with me that they have considered suicide? Within our commentary, we review the current literature and clinical practices regarding these questions and close with actionable suggestions and recommendations for future directions.
Insight into planktonic protistan and fungal communities across the nutrient-depleted environment of the South Pacific Subtropical Gyre
Authors: Kajan Katarina , Fuchs Bernhard M. , Orlić Sandi 
Published: February 2024

ABSTRACT

Ocean microorganisms constitute ~70% of the marine biomass, contribute to ~50% of the Earth’s primary production, and play a vital role in global biogeochemical cycles. The marine heterotrophic and mixotrophic protistan and fungal communities have often been overlooked mainly due to limitations in morphological species identification. Despite the accumulation of studies on biogeographic patterns observed in microbial communities, our understanding of the abundance and distribution patterns within the microbial community of the largest subtropical gyre, the South Pacific Gyre (SPG), remains incomplete. Here, we investigated the diversity and vertical composition of protistan and fungal communities in the water column of the ultra-oligotrophic SPG. Our results showed apparent differences in protistan community diversity in the photic and aphotic regions. The entire protistan community diversity was significantly affected by temperature, salinity, oxygen, and nutrient concentrations, while the parasitic community diversity was also affected by chlorophyll
a
concentration. The parasitic protists were assigned to the class Syndiniales accounting for over 98% of the total parasitic protists, exhibiting higher relative sequence abundance along the water depth and displaying consistent patterns among different sampling stations. In contrast to the protistan community, the fungal community along the SPG primarily clustered based on the sampling station and pelagic zones. In particular, our study reveals a significant presence of parasitic protists and functionally diverse fungi in SPG and their potential impact on carbon cycling in the gyre.

IMPORTANCE
Our findings carry important implications for understanding the distribution patterns of the previously unrecognized occurrence of parasitic protists and functionally diverse fungi in the nutrient-limited South Pacific Gyre. In particular, our study reveals a significant presence of parasitic Syndiniales, predominantly abundant in the upper 300 m of the aphotic zone in the gyre, and a distinct presence of fungal communities in the aphotic zone at the central part of the gyre. These findings strongly suggest that these communities play a substantial role in yet insufficiently described microbial food web. Moreover, our research enhances our understanding of their contribution to the dynamics of the food webs in oligotrophic gyres and is valuable for projecting the ecological consequences of future climate warming.