bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-Faktor Yang Berpengaruh Terhadap Motivasi Petani Dalam Pembuatan Pupuk Organik Cair Dari Limbah Tempe
Authors: Anantariya Ucca , Romadi Ugik , Harwanto Harwanto 
Published: October 2023

Abstrak
Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berpengaruh terhadap motivasi petani dalam pembuatan pupuk organik cair limbah tempe. Penelitian ini dilakukan di Desa Beji Kecamatan Junrejo Kota Batu Jawa Timur pada bulan Maret-Mei 2023. Pengambilan sampel dilakukan dengan metode purposive sampling dimana dari 11 kelompok tani terpilih 3 kelompok tani yang masuk dalam kriteria yang ditentukan dengan jumlah 70 orang. Pengumpulan data dilakukan dengan wawancara dan menggunakan kuesioner yang telah diuji validitas dan reliabilitas. Analisis data yang digunakan yaitu regresi linier berganda dengan SPSS 25. Hasil penelitian menunjukan bahwa faktor-faktor yang berpengaruh terhadap motivasi petani dalam pembuatan pupuk organik cair dari limbah tempe yaitu umur, lama berusahatani, pendidikan, keuntungan dan kerumitan. Luas lahan, kekosmopolitan, serta sarana dan prasarana tidak berpengaruh nyata terhadap motivasi petani.
Synergistic Effects of Paclitaxel and Sulforaphane in Prostate Cancer Treatment: Mechanistic Insights for Optimizing Combination Therapy
Authors: Habib Tito Naeem , Altonsy Mohamed Omar , Ghanem Salah Abdelmoneim , Salama Mohammed Said , Hosny Mai Abd El Hafieth 
Published: October 2023

Abstract
Background: In cancer therapy, combining treatments can result in additive and synergistic outcomes, reducing the development of drug resistance compared with monotherapy. We propose that combining Paclitaxel (Taxol, PTX) with Sulforaphane (SFN) may result in better treatment outcomes in prostate cancer. Understanding the mechanism of drug synergy, as opposed to simply knowing which drugs to combine, enables further optimization of advantageous drug interactions and can provide efficient therapeutic strategies in preclinical research.
Methods: We measured apoptosis, cell cycle, and expression of Bax and Bcl2 in response to individual and combined treatments of PTX and SFN in PC-3 and LNCaP cells. Different concentrations of PTX, SFN, and their combination were used. We conducted Annexin V/PI positivity and data analysis using a flow cytometer and guava data acquisition and analysis software. Statistical analyses and graph generation were performed using Graph-Pad Prism 6 and Microsoft Excel software. Student’s t-tests or one-way analysis of variance with Tukey’s correction were used to determine the significant difference between mono- and combination treatments.
Results: The effect of PTX or SFN treatments on reducing cell viability increased in a dose-dependent manner. Combined treatment enhanced PTX’s effects and reduced the EC50 values of both drugs compared to individual treatments. Flow cytometry analysis revealed that PTX or SFN treatments redistributed cell-cycle phases by inducing S-phase arrest and increasing the apoptotic cell population in PC-3 cells. These effects were further enhanced in the PTX+SFN combination group. Interestingly, the combination treatments did not affect the necrotic cells. Caspase-3 cleavage and morphological deformations of the cell nuclei were examined by western blot and fluorescent microscopy in response to mono- and combination treatments, indicating apoptotic cell death.
Conclusion: The PTX or SFN treatments differentially modulated the expression of Bax and Bcl2 in PC-3 and LNCaP cell lines, and the combined treatment enhanced these effects in favor of cell apoptosis versus survival. Our data indicated that combination therapy of PTX and SFN significantly increased Bax protein expression and Bax: Bcl2 ratio compared to PTX or SFN individual treatments. These findings could help develop new biomarkers and guide therapy choices. Understanding the mechanism of drug synergy is essential to optimize drug interactions and provide efficient therapeutic strategies in preclinical research.
Development and Internal Validation of a Novel Pre-Transplant Biomarker Panel to Predict Post-Liver Transplant Mortality
Authors: Panayotova Guergana G. , Simonishvili Sopio , Nguyen Duc T. , Graviss Edward A. , Aware Nikita , Manner Carl J. , Minze Laurie J. , Ayorinde Tumininu , Qin Yong , Jin Lianhua , Lemenze Alexander , Mysore Krupa R. , Moore Linda , Paterno Flavio , Saharia Ashish , Mobley Constance M. , Amin Arpit , Hobeika Mark J. , Pyrsopoulos Nikolaos , Li Xian C. , Guarrera James V. , Ghobrial R. Mark , Lunsford Keri E. 
Published: October 2023

Abstract

Current scoring systems accurately predict risk of pre-liver transplant (LT) mortality but fall short in estimation of post-LT survival. This study seeks to identify biomarkers of pre-LT immune dysfunction that predict mortality following LT. From 10/1/13-3/23/21, 279 cirrhotic patients underwent assessment of plasma biomarker (Luminex) and clinical variables immediately prior to LT (T0). Cox-proportional hazards modeling identified HCV IgG, Fractalkine, and MMP3 as multivariate predictors of 1-year mortality, with covariate selection by clinical importance and LASSO methodology. These were utilized to comprise the novel Liver Immune Frailty Index (LIFI), which stratifies recipients into -low, -moderate, and –high risk tertiles. One-year mortality was 1.4%, 12.7%, and 58.3% for LIFI-low, -moderate, and -high, respectively. Internal validation through bootstrap resampling with 2000 replicates demonstrates LIFI predicts early post-LT mortality with C-statistic=0.84 and Brier score of 0.04. LIFI may identify patients at risk for persistent severe immune dysfunction and early mortality following LT.
The effect of urbanization and behavioral factors on coyote net displacement and its implications for seed dispersal
Authors: Gelmi-Candusso Tiziana A. , Wheeldon Tyler J. , Patterson Brent R. , Fortin Marie-Josée 
Published: October 2023

Abstract
Coyotes (Canis latrans) may be important seed dispersal vectors in urban areas, given their omnivorous diet and wide-ranging movement patterns potentially able to bypass fragmentation. Yet, fragmentation itself, anthropogenic food sources, and human activity can limit their natural movement patterns. Previous research has found urbanization limits movement range across mammals; however, it remains unclear the degree to which this may cascade into seed dispersal as seed retention time also plays an important role in seed dispersal distance. Additionally, social and temporal changes in behavior influence coyote movement patterns, likely interacting with the effect of urbanization on net displacement and, consequently, seed dispersal. We used GPS telemetry data to analyze the effect of urbanization on coyote net displacement (n=94 individuals), in interaction with social and temporal factors, for a series of seed retention timeframes. We found that urbanization led to shorter net displacement in comparison to rural areas. The effect of urbanization increased with increasing seed retention timeframe and disproportionately affected long-distance seed dispersal. Seasonality influenced the effect of urbanization to a smaller extent than social status. Social status had a strong interaction effect, as urbanization negatively impacted the net displacement of transient and dispersing coyotes but had a negligible influence on resident coyotes. Territoriality was likely the main limiting factor for the latter, whereas the former, which were wider ranging, were likely most affected by the landscape configuration. In terms of seasonality, climate seasons explained variability in the data better than biological seasons, where net displacement remained more stable across climate seasons in urban areas, as opposed to rural areas, where net displacement increased during winter and decreased during summer. Interestingly, despite the urban effect, coyote net displacement varied across social statuses and seasons in both landscape types, suggesting coyotes can provide a heterogenous seed dispersal contribution within and across plant species. Future research on fine-scale movement patterns and scat analysis is needed to better understand the cascading effects of decreased long-distance net displacements on urban plant populations.
Dynamics of topological phonon boundary modes in polymer chains and supramolecular lattices on surfaces
Authors: Palma Carlos-Andres , Polthier Konrad , Rondomanski Jakub , González José Cojal , Rabe Jürgen 
Published: October 2023

Abstract

In topological band theory, phonon boundary modes with non-trivial topology feature desirable properties for atomically-precise technologies, such as robustness against defects, waveguiding and one-way transport. Topological phonon properties remain to be studied both theoretically and experimentally in low-dimensional materials at the atomistic level, such as polymer chains and self-assembled supramolecular lattices, especially under thermal fluctuations. Here we show by means of molecular simulations that polymer chains and weakly-interacting supramolecular lattices following modified Su-Schrieffer-Heeger (SSH) phonon models with heavy boundaries, express robust topological phonon boundary modes under thermal fluctuations. The topological boundary modes propagate upon excitation of a single molecule, contrary to free boundary modes. Our work is an entry to topological vibrations and their corresponding non-Euclidean metric in supramolecular systems, and may find applications in the realization of Hall effect phonon analogues at the molecular scale
Development of Industrial Occupational Safety and Health Models in Manufacturing Industries the Case of Akaki Basic Metal Industry
Authors: Tesfaye Fasil Kebede 
Published: October 2023

Abstract
Manufacturing is a significant sector of the economy in many nations and is frequently regarded as an engine of economic expansion, particularly in developing nations. Despite its importance, the metal sector is seen as unsafe due to frequent and high accident rates as well as worker health issues. Therefore, the primary goal of this research is to create a safety model with the goal of development in occupational safety and health in order to reduce workplace injuries, diseases, and deaths in the Akaki Basic Metal Industry. The hypothesized model was developed and tested on a sample 215 respondents who worked for production businesses. The Statistical Package for the Social Sciences (SPSS) version 23.0 was used to enter and analyze the acquired data, and the Analysis Moment of Structure (AMOS) version 21 software was used to build the model. Through the use of structural equation modeling (SEM) and confirmatory factor analysis (CFA), research models were examined and confirmed. A good-fit structural model (PCLOSE = 0.001, Goodness of Fit Index = 0.971, Root Mean Square Error of Approximation = 0.121, Comparative Fit Index = 0.986 and TLI = 0.906) indicated that Safety culture, safety police and safety climate constructs direct influence on firm productivity. The new structural model can be used to provide better understanding of the links between firm productivity indicators and contributing components, and make stronger recommendations for effective intervention in construction projects
Reflections of the Spices Mentioned in the Health Recipes Applied for Centuries by Ibn Sina on the Ottoman Palace Cuisine
Authors: Başar Fatma , Başar Burak , Akoğul Emre 
Published: October 2023

Abstract
The relationship between diseases and nutrition, along with the practice of recommending specific foods and beverages in addition to medications, is a phenomenon that has persisted from ancient times to the present day. The utilization of meat, vegetables, herbs, and spices in the context of dietary therapy is a common approach. In Ottoman palace cuisine, the medical prescriptions administered by Ottoman physicians influenced the culinary creations of the palace. Therefore, this study aims to assess the use of spices in the preparation of dishes within Ottoman palace cuisine and their role within Ibn Sina's medicinal formulations. In essence, this research seeks to shed light on the culinary philosophy of the palace kitchen culture, which was deeply influenced by the longstanding tradition of Ottoman medicine that developed over an extensive period.
The impact of cultural, socioeconomic, behavioral and health disadvantages on the incidence and severity of chronic kidney disease:A case- control study of Uddanam region of Andhra Pradesh, India.
Authors: Pampana Hari Ram , Addanki Sadguri , Lakkamraju Dhanunjaya Varma , Godi Sudhakar , Gangisetti Paddaiah 
Published: October 2023

Abstract

BackgroundPresently both developed and developing countries are suffering from chronic kidney disease (CKD) worldwide. CKD with unknown etiology rapidly and silently affects people without any prior symptoms. Loss of renal function due to progressive loss of glomerular filtration rate (GFR) and co morbidities is an important factor leading to adult mortality. This study aimed at to investigate the impact of cultural, socioeconomic, behavioral and health factors on chronic kidney disease prevalence and severity in Kaviti and Kanchili Mandals within the Uddanam region of North Coastal Andhra Pradesh, India.MethodsA case‒control study was conducted on 2806 participants (1001 CKD patients and 1001 healthy controls in Kaviti Mandal and 402 CKD patients and 402 healthy controls in Kanchili mandal of the Uddanam region. Logistic and multiple regression analyses and independent t-tests were applied to measure the association between selected parameters such as average spending per month on transport, diagnosis and medicine juxtaposed to various parameters of CKD and normal families.ResultsIn the Uddanam region, the patient’s average spending costs per month on transport to the hospital, diagnosis, and medicine were 919/-, 1225/-, and 2076/-, respectively, and stage 4 and 5 patients were spent more money for treatment of the disease. The logistic regression analysis revealed that the people in the open category(OROC/SC&ST= 5.132, 2.513-10.48), lower economic category (ORLOWER/UPPER= 7.011, 1.482-33.17), farmers (ORFARMER/ANY OTHER=1.620 (1.226-2.14), those in the education system primary education group (ORPRIMARY/COLLEGEANDABOVE=3.246,9.598-25.766), hypertensive individuals (ORYES/NO= 5.088,4.2-6.16) and people who had other ailments (ORYES/NO= 3.714, 2.992-4.61) had a significant risk association with CKDu.ConclusionThe present study revealed that living in rural areas and belonging to lower socioeconomic status per se play a significant role in the causation of chronic kidney disease and that these CKD patients spend more money to treat the disease as it progresses. The improvement of health care facilities especially specialties dealing with kidney diseases and creating awareness of CKD risk factors are needed.
Regional trans-arterial immunotherapy combined with intravenous chemotherapy in patients with locally advanced cervical cancer as preoperative neoadjuvant therapy: A case series study
Authors: Huang Qidan , Tong Chongjie , Huang Zhimei , Gu Yangkui , Yang Fan , Zhou Wenhao , Yan Shumei , Carly Ha Ka Lee , Luo Nanbin , Xiong Ying 
Published: October 2023

Abstract

Background: This study was to evaluate the effectiveness and safety of the preoperative regional trans-arterial immunotherapy combined with intravenous chemotherapy in patients with locally advanced cervical cancer (LACC).
Methods: Trans-arterial programmed cell death receptor 1 (PD-1) monoclonal antibody infusion combined with intravenous paclitaxel-cisplatin chemotherapy was adopted as neoadjuvant therapy in six patients with primary LACC (stage IIB-IVA) who were willing to undergo surgical resection, and treatment effectiveness was evaluated according to the RECIST 1.1 criteria. If the local tumor was regressive and assessed as operable, surgery was performed, and postoperative adjuvant therapy was selected based on the histopathological findings.
Results: One patient was discontinued the neoadjuvant therapy from the study due to an allergic reaction during the 2nd course and underwent surgical resection directly. Five patients achieved partial response after neoadjuvant therapy with an objective response rate of 100% and a surgical conversion rate of 100%. All patients had R0 resection. Serious adverse events did not occur during neoadjuvant therapy. The six patients were followed up for 15-30 months (median, 23.5 months) and none of them relapsed.
Conclusions: Trans-arterial PD-1 monoclonal antibody infusion combined with intravenous paclitaxel-cisplatin as neoadjuvant therapy in patients with LACC showed a higher objective response rate, surgical conversion rate, and safety with satisfactory near-term outcomes. Further investigation is required to substantiate the outcome of regional trans-arterial infusion immunotherapy combined with intravenous chemotherapy as an alternative treatment modality for LACC.
Metabolomic screening of radioiodine refractory thyroid cancer patients and the underlying chemical mechanism of iodine resistance
Authors: Zheng Weihui , Tang Xi , Dong Jinyun , Feng Jianguo , Chen Min , Zhu Xin 
Published: October 2023

Abstract

Background: Radioiodine refractory (RAIR) patients do not benefit from iodine-131 therapy. Thus, timely identification of RAIR patients is critical for avoiding ineffective radioactive iodine therapy. In addition, determining the causes of iodine resistance will facilitate the development of novel treatment strategies.
Methods: This study was comprised of 20 RAIR and 14 non-radioiodine refractory (non-RAIR) thyroid cancer patients. Liquid chromatography-mass spectrometry was used to identify differences in the serum metabolites of RAIR and non-RAIR patients. In addition, chemical assays were performed to determine the effects of the differential metabolites on iodine uptake.
Results: Metabolic pathway enrichment analysis of the differential metabolites revealed significant differences in the phenylalanine and tyrosine metabolic pathways. Notably, quinate and shikimic acid, metabolites of the tyrosine pathway, were significantly increased in the RAIR group. In contrast, the phenylalanine pathway metabolites, hippuric acid and 2-phenylacetamide, were markedly decreased in the RAIR group. Thyroid peroxidase plays an important role in catalyzing the iodination of tyrosine residues, while the ionic state of iodine promotes the iodination reaction. Quinate, shikimic acid, hippuric acid, and 2-phenylacetamide were found to be involved in the iodination of tyrosine, which is a key step in thyroid hormone synthesis. Specifically, quinate and shikimic acid were found to inhibit iodination, while hippuric acid and 2-phenylacetamide promoted iodination.
Conclusions:Abnormalities in phenylalanine and tyrosine metabolic pathways are closely associated with iodine resistance. Tyrosine is required for thyroid hormone synthesis and could be a potential cause of iodine resistance.
The comprehension of bioremediation for the isolation and characterization of heavy metal tolerant Aeromonas sanarellii bacteria in the wastewater-contaminated soil
Authors: Aravind Chidambaram , Sivaji Subhashini , Nagaraj Harashavardhan , Ramya Priyanga Prasanna , Jayaram Lavanya , Anandakumar Shanmugam , Sivakumar Durairaj , Prabu Dhandapani 
Published: October 2023

Abstract

The large number of toxic metals accumulate in water and soil environment as a result of unmanaged industrial waste disposal, significantly impacting a variety of health-related issues. Heavy metal resistance is very high among microorganisms in the soil's rhizosphere. In this work, we isolated such naturally existing rhizosphere bacteria Aeromonas sanarellii (A. sanarellii) from heavily contaminated soil in the Anakaputhur area, southern part of Chennai city, India. On the basis of the partial amplification of 16S rRNA using new primers, A. sanarellii was molecularly identified. Then, 33 strains were used to align the sequence in order to study phylogenetic relationships using the neighbour joining method. This study assessed its ability of reducing and detoxifying heavy metals based on the results of subsequent testing. The effective concentration (EC50) and the internationalization of heavy metals were determined using spectrophotometric method. The structural changes in tolerant bacteria were studied using Scanning electron microscope (SEM). Protein profiling was performed using SDS PAGE and MALDI TOF analysis. Amount of metallothionein produced upon exposure was measured by using UV-Vis spectrophotometer. This study found that, as a consequence, selecting A. sanarellii based on their heavy metal resistance and biodegradation ability could serve as a starting point for developing potential bioremediation agent for toxic effluent treatment technology.
“I only seek treatment when I am ill”: Experiences of hypertension and diabetes care among adults living with HIV in urban, Tanzania
Authors: Ottaru Theresia A. , Wood Christine V. , Butt Zeeshan , Hawkins Claudia , Hirschhorn Lisa R. , Karoli Peter , Shayo Elizabeth H. , Mettah Emmy , Chillo Pilly , Siril Hellen , Kwesigabo Gideon 
Published: October 2023

Abstract

Background
For adults living with HIV (ALHIV) and comorbidities, access to comprehensive healthcare services is crucial to achieving optimal health outcomes. This study aims to describe lived experiences, challenges, and coping strategies for accessing care for hypertension and/or diabetes (HTN/DM) in HIV care and treatment clinics (CTCs) and other healthcare settings.
Methodology
We conducted in-depth interviews with 33 ALHIV with HTN (n=16), DM (n=10), and both (n=7), purposively recruited from six HIV CTCs in Dar-es-Salaam, Tanzania. Thematic content analysis was guided by the 5As framework domains (availability, accommodation, affordability, acceptability, and accessibility).
Results
Participants sought HTN/DM care including screening and management at non-CTC health facilities due to the limited availability of such services at HIV CTCs. However, healthcare delivery for these conditions was perceived as unaccommodating and poorly coordinated. The need to attend multiple clinic appointments for the management of HTN/DM in addition to HIV care was perceived as frustrating, time-consuming, and financially burdensome. Participants reported difficulty paying for their HTN/DM medications and non-HIV CTCs providers’ consultation costs. High costs of care and transportation, limited understanding of comorbidities, and the perceived complexity of HTN/DM care contributed to HTN/DM treatment discontinuity among ALHIV. As a means of coping, participants frequently monitored their own HTN/DM symptoms at home. When symptoms were a problem, participants utilized community pharmacies and dispensaries near their residences to check blood pressure and sugar levels and obtain medications. These approaches were preferred to seeking care at the HTN/DM care sites due to the costs. Limited education in HTN/DM management was provided at all health facilities including HIV CTCs. Participants expressed a preference for non-pharmaceutical approaches to comorbidity management such as lifestyle modification and herbal therapies because of concerns about side effects and perceived ineffectiveness of HTN/DM medications. Participants also preferred integrated care and focused health education on multimorbidity management at HIV CTCs.
Conclusion
Our findings highlight significant barriers to accessing HTN/DM care among ALHIV, mostly related to affordability, availability, and accessibility. Integration of NCD care into HIV CTCs, with attention to cost and other barriers, could greatly improve ALHIV health access and outcomes and align with patient preference.