bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review on Psoriasis Pathophysiology, Clinical Appearance, and
Pharmacotherapeutic Interventions
Authors: Kumar Deepak , Majhi Sagarika , Sharma Meenakshi 
Published: December 2023

Abstract:
A chronic skin condition called psoriasis can manifest as plaque, flexural, guttate, pustular, and erythrodermic lesions, among other clinical
symptoms. Sixty million people are believed to be affected by psoriasis worldwide. In India, the frequency ranges from 0.44 to 2.8%, with males
affected two times more frequently than females in their third or fourth decade of life. An immune-mediated inflammation condition with a sizable
genetic component is psoriasis. Due to its connection to psoriatic arthritis and the increased prevalence of cardiometabolic, hepatic, and psychiatric
problems, a thorough and interdisciplinary strategy for treatment is required. Corticosteroids and analogs of vitamin D are examples of topical
treatments for psoriasis. Phototherapy includes NB-UVB, psoralen, and ultraviolet radiation (PUVA). Standard systemic treatments include
methotrexate, acitretin, and ciclosporin. This disease is useful for physicians and scientists since it might be used as a model for research into the
underlying causes of chronic inflammation. It is also crucial for clinical trial scientists as a first-choice disease indication for preliminary research
of new pathogenesis-based treatment approaches. This review covers both the therapeutic choices that have resulted from the analysis of the
aggressive psoriatic pathways and the processes involved in the onset and progression of the disease. We start by writing regarding the important
cell kinds and inflammatory mechanisms that initiate and maintain psoriatic inflammation. Next, we discuss how skin flora interacts with heredity,
related epigenetic processes, and the pathogenesis of psoriasis. Finally, we provide a thorough analysis of recently targeted medications as well as
well-known, extensively used treatments.
A Comprehensive Review of Abroma Augusta (Devil's Cotton): Phytochemical
Constituents, Ethnomedicinal Applications, and Pharmacological Properties
Authors: Balkrishna Acharya , Mishra Shailja , Dhyani Ashish , Saini Priyanka , Arya Vedpriya , Sharma Nidhi 
Published: December 2023

Abstract:
The nutritional and therapeutic potential of medicinal plants is constantly being investigated. This is especially relevant in today's world, where an
increasing number of people are turning to complementary and alternative therapies to address their health-related concerns. Traditional
knowledge, as a valuable resource, plays a crucial role in the development of new herbal medicines. Abroma augusta stands out as one such
medicinal plant that has a rich history of use in traditional medicine. It has been employed to address a wide spectrum of health issues, including
diabetes, menstrual irregularities, respiratory problems, musculoskeletal disorders, urinary ailments, and sexual dysfunctions, among others. While
various parts of this plant species are believed to possess pharmacological properties, the active compounds and underlying mechanisms remain
largely unexplored. To facilitate the development of innovative drugs for the benefit of individuals, this study places significant emphasis on
delving into the phytochemical and ethnomedicinal attributes of A. augusta. Moreover, it seeks to bolster its findings with scientifically validated
pharmacological investigations conducted through both in vivo and in vitro methodologies.
One-step Synthesis of Deep Eutectic Solvents and Dissolution of Kraft Lignin
Authors: Merino Pérez Omar , Cerón-Camacho Ricardo , Martínez-Palou Rafael 
Published: December 2023

Abstract:
Lignin is a very abundant biopolymer with great potential to produce other high-value polymers with aromatic groups. Its valorization has been limited principally by its poor solubility in conventional organic solvents, which makes it difficult to deconstruct or transform it into other products with higher added value. In this work, we describe a one-pot procedure to prepare vari-ous Deep Eutectic Solvents and study their ability to dissolve Kraft lignin with the aid of micro-wave dielectric heating efficiently.

Background::
Lignin is a widely available aromatic biopolymer that is largely discarded or used as a low-value fuel when separated in paper production processes, so researchers are engaged in the development of lignin dissolution processes that allow its easy deconstruction and transfor-mation into other products with higher added value.

Objective::
The main objective of this work is to find deep eutectic solvents capable of dissolving significant quantities of lignin with the aid of microwaves as a heating source.

Method::
The present work developed a simple, fast, and efficient method to dissolve lignin using Deep Eutectic Solvent/acetonitrile as solvents and irradiation by dielectric microwave heating.

Results::
Most of the DESs studied achieved significant dissolution of purchased lignin with com-mon organic solvents by employing microwave irradiation as the heating method.

Conclusion::
Some DESs studied in this work are good alternatives as solvents for lignin solvent option of simple preparation from renewable precursors from biomass, such as glycerol, choline chloride, and urea, of low toxicity and cost for this application. The effectiveness of these systems appears to be based on molecular recognition by hydrogen bonding interactions involving the three species that make up the eutectic and the hydroxyl groups of the lignin. These solvents can be recovered and recycled.
An Environmental Objects Feature Detection Algorithm based on Image Detection in the Power Transmission System
Authors: Zhu Zhongxian , Cai Kewei , Liu Wentao , Du Yao , Wang Ying 
Published: December 2023

Background:
The image processing technology can be adopted in the power transmission
incident detection system, when it is combined with artificial intelligence and machine learning
academic knowledge of power transmission surveillance video analysis system, it can automatically
detect abnormal objects in the power transmission system. It can quickly and accurately
detect abnormal objects, known as environmental object feature detection necessary for the safety
of power transmission system.

Objective:
In order to improve the object detection ability of the power transmission system, it
adopts artificial intelligence and machine learning knowledge in the power transmission surveillance
system and it can automatically detect abnormal events or objects.

Methods:
Compared with differential binary target detection technique, it proposes a new adaptive
background subtraction threshold algorithm to adapt the complex power transmission monitoring
environment. Meanwhile, it takes special recognition algorithm for power transmission monitoring
environment to ensure the accuracy and stability of the detection system.

Results:
The proposed method can be used in the monitoring system and the accuracy and stability
of the detection system have been verified through experiments.

Conclusion:
Through adopting the special recognition algorithm for power transmission monitoring
environment, it can ensure the accuracy and stability of the detection system, in the detection
experiments, it can analyze the objects more easily than before.
Redox Modulation of Meniere Disease by Coriolus versicolor Treatment, a
Nutritional Mushroom Approach with Neuroprotective Potential
Authors: Paola Rosanna Di , Siracusa Rosalba , Fusco Roberta , Ontario Marialaura , Cammilleri Gaetano , Pantano Licia , Scuto Maria , Tomasello Mario , Spanò Sestina , Salinaro Angela Trovato , Abdelhameed Ali S. , Ferrantelli Vincenzo , Arcidiacono Antonio , Fritsch Tilman , Lupo Gabriella , Signorile Anna , Maiolino Luigi , Cuzzocrea Salvatore , Calabrese Vittorio 
Published: December 2023

Background:
Meniere's disease (MD) is a cochlear neurodegenerative disease. Hearing loss
appears to be triggered by oxidative stress in the ganglion neurons of the inner ear.

Objective:
Here, we confirm the variation of markers of oxidative stress and inflammation in patients
with Meniere and hypothesize that chronic treatment with Coriolus mushroom helps in the response to
oxidative stress and acts on α-synuclein and on NF-kB-mediated inflammatory processes.

Methods:
Markers of oxidative stress and inflammation were evaluated in MD patients with or without
Coriolus treatment for 3 or 6 months.

Results:
MD patients had a small increase in Nrf2, HO-1, γ-GC, Hsp70, Trx and sirtuin-1, which were
further increased by Coriolus treatment, especially after 6 months. Increased markers of oxidative
damage, such as protein carbonyls, HNE, and ultraweak chemiluminescence, associated with a decrease
in plasma GSH/GSSG ratio, were also observed in lymphocytes from MD patients. These parameters
were restored to values similar to the baseline in patients treated with Coriolus for both 3 and
6 months. Furthermore, treated MD subjects showed decreased expression of α-synuclein, GFAP and
Iba-1 proteins and modulation of the NF-kB pathway, which were impaired in MD patients. These
changes were greatest in subjects taking supplements for 6 months.

Conclusions:
Our study suggests MD as a model of cochlear neurodegenerative disease for the identification
of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences
associated with neurodegenerative damage, probably by indirectly acting on a-synuclein expression
and on inflammatory processes NF-kB-mediated.
The Green Approach of Cerium Oxide Nanoparticle and Its Application for Photo-degradation of Phenol Dye
Authors: Putri Gusliani Eka , Arief Syukri , Ritonga Ahmad Hafizullah , Fitri Wiya Elsa , Arman Eliza , Telaumbanu Arniat Christian , Yusuf Rahmi Novita 
Published: December 2023

The approach to the synthesis of cerium oxide nanoparticles (CeO2NPs) using plants as capping agents has been widely researched because of its eco-friendly, low-cost, simple, effective, and reusability. In this research, we used Moringa oleifera leaf extract-mediated CeO2NPs. CeO2NPs were characterized by XRD, FTIR, SEM, TEM, and DRS UV-vis. The photocatalytic activity of CeO2NPs was tested using a phenol dye concentration of 7 mg/L with variations in photocatalyst weight of 10, 20, 30, 40, 50, 60, 70, 80, 90, and 100 mg under UV irradiation, respectively, with time variations of 15, 30, 45, 60, 75, 90, 105, 120, 135, and 150 min. SEM and TEM morphology results showed that the CeO2NPs were spherical and agglomerated. The crystal structure is cubic, with a crystal size of 18 nm with a band gap of 2.87 eV. CeO2NPs showed high photo-degradation phenol dye of 94.45% under visible light in 120 min irradiation time. The results show that M. oleifera leaf extract could be as inexpensive and safe for synthesizing other metal oxide nanoparticles, potentially having applications in the biomedical and environmental fields.
PLA/LLDPE/Organo-Precipitated Calcium Carbonate Composites Containing LLDPE-g-OA Compatibilizers: Mechanical, Physical, Thermal, and Morphology
Authors: Ritonga Ahmad Hafizullah , Aritonang Barita , Putri Gusliani Eka , Khairiah Khairiah , Siahaan Enzo Wiranta Battra , Meilani Debi 
Published: December 2023

A plastic composite consisting of polylactic acid (PLA), linear low-density polyethylene (LLDPE), oleic acid-grafted linear low-density polyethylene (LLDPE-g-OA) compatibilizer, and organo-precipitated calcium carbonate (O-PCC) have been successfully made in the molten state. This study aims to characterize the mechanical, physical, thermal, and morphological characteristics of the PLA/LLDPE/O-PCC plastic composite in the presence of an LLDPE-g-OA compatibilizer. The plastic composite was prepared by blending PLA, LLDPE, LLDPE-g-OA, and O-PCC using an internal mixer with a heating of 160 °C and a rotation of 100 rpm. LLDPE and LLDPE-g-OA are put together into the inner mixer chamber until melted, followed by PLA and O-PCC. The most optimum plastic composite composition is PLA/LLDPE/LLDPE-g-g-OA/O-PCC (67.5:22.5:5:5). The mechanical properties showed an increase in tensile strength of 9.78 MPa. The physical properties showed that the minimum water absorption was 0.74%, the biodegradation in humus soil showed a degradation rate of 0.09% per day, and the thermal properties showed better stability with a melting point of 146.5 °C. The FTIR spectrum is similar to the polymer blend without O-PCC. The morphology indicates that the composite is compatible and homogeneous. This semi-biodegradable plastic composite has significant implications for reducing the accumulation of plastic waste in the environment.
Navigating the Digital Landscape: Unraveling Technological, Organizational, and Environmental Factors Affecting Digital Auditing Readiness in the Malaysian Public Sector
Authors: Wan Mohamad Noor Wan Nurul Basirah , Abd Razak Siti Noor Azmawaty , Mat Jusoh Yusri Huzaimi , Hasan Siti Jeslyn 
Published: December 2023

ABSTRACT
The tremendous development of IT requires auditors to be equipped with IT knowledge and tools to navigate the rapid development of e-government in public sectors, supporting the nation’s transformation agenda. However, the audit technology used by public sector auditors remains underutilized. This study examines Malaysian public sector internal auditors’ readiness for digital auditing. Questionnaires were distributed to 149 internal auditors, and the data were analyzed using PLS-SEM. Findings revealed that only technological and environmental factors were found to have a significant influence on the readiness of internal auditors to utilize digital auditing in their jobs, whereas organizational factors had no significant influence. The findings are anticipated to enrich the body of knowledge on the readiness of Malaysian public sector internal auditors to embrace digitalization as part of their routine. Understanding determinants is crucial for authorities to ensure digital economy players, including public sector internal auditors, are technology-ready for digital competencies.
JEL Classifications: M42; M48.
Tecnología educativa ‘introducida’ por la pandemia COVID-19
Authors: Koutska Iva 
Published: December 2023

Vinculado al intento de la sociedad de ajustarse a la pandemia de la Covid-19, han surgido nuevos retos en todas las esferas de la vida. La presión de adaptar la labor educativa en una sociedad con restricciones fue, mayoritariamente, tarea del personal docente. El objetivo del presente artículo es realizar una trasferencia positiva del conocimiento de la tecnología educativa, tanto dentro como fuera de los tiempos de la pandemia. El artículo presenta dos análisis cualitativos sobre la preferencia de la tecnología por parte de los docentes. El primero se basa en la interpretación de los datos recogidos, sometidos a cálculo cuantitativo con el software EXCEL, para conseguir las frecuencias de uso de una u otra tecnología. El segundo análisis interpreta la tecnología por grupos temáticos, basados en su función. El estudio muestra que la educación/enseñanza a distancia ha pasado por muchos cambios causados por la pandemia. La tecnología ayudó a la educación/enseñanza a continuar a pesar de la pérdida de lo físico, y la tecnología educativa, especialmente las soluciones basadas en páginas web, han facilitado a los docentes el camino a seguir para mantener y mejorar la calidad del mismo proceso educativo. Comparando con el pasado durante el cual los instrumentos de educación a distancia se habían utilizado asincrónicamente, la pandemia ha posibilitado el uso de posibilidades interactivas y portátiles más colaborativa y comunicativas. También ha incrementado la variedad de los propios instrumentos. Ahora existe más de una solución para cubrir la misma o parecida función. El artículo trabaja una extensa cantidad de datos para responder la pregunta “¿qué tecnología educacional empleas?”. Las respuestas las facilitaron profesores, maestros, entrenadores, estudiantes y otras personas interesadas, todo ello para poder ofrecer luego sugerencias para la práctica de una enseñanza más global.
Examination of student satisfaction with e-courses by clustering analysis
Authors: Deveci Topal Arzu , Kolburan Geçer Aynur 
Published: December 2023

Student satisfaction is one of the foremost factors for e-courses to continue efficiently and achieve their goals. The present research aims to analyze the clustering tendencies of e-course students’ satisfaction with e-courses according to the variables of “gender, class, computer ownership, computer and internet literacy, duration of internet use, the connection type to the internet, and the tools utilized by the students in the learning management system” through clustering algorithms, one of the data mining techniques. The survey model was employed. A 35-item satisfaction scale devised for students taking e-courses was used for data collection. A total of 522 students taking online courses at a university participated in the study. Descriptive statistics and cluster analysis were employed to analyze and interpret the data. As a result of the analyses through K-Means cluster analysis, four different clusters were obtained. Those clusters were defined in accordance with the variables they included as follows: Cluster 1 (the group with the highest rate of computer ownership and the highest computer literacy); Cluster 2 (the group with the lowest rate of computer ownership and the lowest computer literacy); Cluster 3 (students have low computer literacy and low duration of Internet use), and Cluster 4 (the group with the highest rate of females, first graders, and those who use the Internet at “good” and “very good” levels) . According to the research results, the mean student satisfaction levels regarding e-courses were determined to be low in general. As per the clustering analysis, it was observed that the students in Cluster 1 and Cluster 4 had the highest mean values of satisfaction with e-courses and a “good” level of satisfaction compared to the other groups, while Cluster 2 had the lowest mean value. Cluster 3, on the other hand, was the one with a “medium” level of satisfaction.
Impact of Intermittent Hypoxia-Hyperoxia Therapy in COPD Patients - Pilot Study
Authors: Uzun Andreea-Bianca , Nedelcu Andreea-Dalila , Stanciu Liliana-Elena , Iliescu Mădălina-Gabriela , Tofolean Doina Ecaterina 
Published: December 2023

Abstract
Introduction. Intermittent hypoxia-hyperoxia therapy can contribute to increasing exercise tolerance in patients with cardiovascular, bronchopulmonary, metabolic, and neuropsychiatric pathologies, according to studies in the specialized literature. This therapy consists of the use of hypoxic intervals, interspersed with hyperoxic episodes.
Material and methods. We present 7 clinical cases of patients admitted to the Balneal and Rehabilitation Sanatorium of Techirghiol (SBRT) for 2 weeks, complaining of polyarticular mechanical pain. These patients were diagnosed with chronic obstructive pulmonary disease (COPD) by the pulmonologist according to the GOLD criteria. During hospitalization, the patients underwent a complex balneo-physical-kinetic treatment, simultaneously with intermittent hypoxia-hyperoxia therapy. Patients were evaluated both at admission and discharge.
Results. The evolution of the patients was favorable, with improvement in symptoms, spirometry, scales used, 6-minute walk test, HTi index and paraclinical investigations. Improvements were identified in respiratory volumes, but also in total serum cholesterol and blood glucose levels.
Conclusions. Obtaining promising results gives indications that intermittent hypoxia-hyperoxia therapy can be an alternative treatment for multiple pathologies, including COPD. The therapy proved to be safe and well tolerated, representing a non-pharmacological therapy that can be included in the therapeutic management of patients with COPD.
Bufo Rana in Homeopathy: Potentization, Toxicology, Clinical Consequences, and Therapeutic Use
Authors: Bjørklund Geir , Storchylo Olha 
Published: December 2023

Abstract
Homeopathy, an alternative treatment method based on the principle of “like cures like,” has gained attention in recent years. This paper focuses on Bufo Rana, a homeopathic remedy prepared from the poison of the Bufo toad. We explore the process of potentization and dosage in homeopathy, discussing the various potencies and the influence of Avogadro’s number. Furthermore, we provide an overview of Bufo species, their historical depictions in art, and the toxicological properties of bufotenine, tryptamine, and bufotoxin found in Bufo toads. The clinical consequences of the Bufo species’ venom, including neurological manifestations and cardiac arrhythmias, and the therapeutic use of Bufo Rana in mental and neurological conditions are discussed. We summarize Bufo Rana’s symptoms and therapeutic relationships based on William Boericke’s materia medica. Further research is warranted to investigate the efficacy and safety of Bufo Rana and its role in treating specific conditions.
Studies and Perspectives on the Types of Corrosion Occurring in Continuous Chromium Plating Plants
Authors: Picu Adrian , Enescu Maria Cristiana , Stoian Elena Valentina , Petre Ivona Camelia 
Published: December 2023

Abstract
Corrosion damage to metal materials is often related not only to metal loss but also to the decommissioning of components from the installations, the replacement and installation of which costs about 3% per year of the cost of the material from which they are made.
The effects of galvanic corrosion on the operation of plants and equipment can be anticipated, observed and controlled. Following an economic analysis and the works to be carried out, a balance can be struck between the impact of corrosion of the mechanical elements in the chrome plating bath and the costs for its prevention. The prevention of corrosion at the design stage can lead to lower annual corrosion-related costs, which are much lower than the costs of remedying the causes when the construction of equipment and plants has already been completed.
The aim of this study is based on an analysis of the effect of electrochemical processes in the chromium plating solution on the copper anode bar in continuous chromium plating plants. Initially the forms of corrosion damage to the metal material were identified and then attempts were made to develop methods to reduce and avoid their destruction.
The Influence of the Stiffness of a Hyperstatic Elastic Beam on the Internal Forces Diagrams and on the Bending Deformations
Authors: Marin Cornel 
Published: December 2023

Abstract
An algorithm using the step function Φ(x-a) from the MATHCAD professional calculation program was used to calculate the bending deformations of an elastic beam suspended by means of tie rods (cables). It allowed the writing of analytical relations of shear and bending internal forces in the beam subjected to bending and the drawing of the corresponding diagrams. Also, the algorithm allowed the writing of the analytical relations of the deformations of the beam (arrows and rotations) with the help of the loading function Ψ (x), respectively its derivative Ψd(x). The numerical simulation presented in this paper allowed finding the practical solution for the proposed problem.