bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of a novel pain management device, AT-04, for endometriosis-related pain: study protocol for a phase III randomized controlled trial
Authors: Ishikawa Hiroshi , Yoshino Osamu , Taniguchi Fuminori , Harada Tasuku , Momoeda Mikio , Osuga Yutaka , Hikake Tamiki , Hattori Youko , Hanawa Michiko , Inaba Yosuke , Hanaoka Hideki , Koga Kaori 
Published: January 2024

Abstract
Background
Endometriosis-related pain encompassing dysmenorrhea, dyspareunia, and chronic pelvic pain, reduces the quality of life in premenopausal women. Although treatment options for endometriosis alleviate this pain, approximately one-third of women still experience pain even after receiving treatment, indicating the need for novel approaches to pain relief in those women. The Angel Touch device (AT-04) is a portable magnetic fields irradiation device that incorporates a combination of mixed alternative magnetic fields at 2 kHz and 83.3 MHz. A phase III trial confirmed the efficacy and safety of AT-02, a prototype of AT-04, for pain relief in patients with fibromyalgia.

Methods
This is a phase III, multicenter, prospective, randomized, sham device-controlled, double-blind, parallel study. The participants will be premenopausal women aged > 18 years who have endometriosis-related pain with at least moderate severity. Considering dropouts, 50 participants have been deemed appropriate. Eligible women will be centrally registered, and the data center will randomly allocate them in a 1:1 ratio to the intervention and control groups. Women in the intervention group will receive electromagnetic wave irradiation generated by AT-04 and those who in the control group will wear a sham device for 16 weeks, and both groups will wear AT-04 for another 4 weeks. The primary outcome measure is the change in the Numeric Rating Scale score at 16 weeks compared with the baseline. Secondary outcome measures are efficacy for pelvic pain including dysmenorrhea and non-menstrual pain, and chronic pelvic pain not related to menstruation, dysmenorrhea, and dyspareunia, and improvement of quality of life during the study period. Safety will be evaluated by device defects and the frequency of adverse events. The study protocol has been approved by the Clinical Study Review Board of Chiba University Hospital, Chiba, Japan, and will be conducted in accordance with the principles of the Declaration of Helsinki and the Japanese Clinical Trials Act and relevant notifications.

Discussion
This study aims to develop a novel method of managing endometriosis-related pain. The AT-04 is an ultralow-invasive device that can be used without inhibiting ovulation, suggesting potential benefits to women of reproductive-age.
Trial registration number Japan Registry of Clinical Trials (jRCTs032230278).
Process analysis of the anaerobe Phocaeicola vulgatus in a shake flasks and fermenter reveals pH and product inhibition
Authors: Keitel Laura , Miebach Katharina , Rummel Lea , Yordanov Stanislav , Büchs Jochen 
Published: January 2024

Abstract
Purpose
The anaerobic gut bacterium Phocaeicola vulgatus (formerly Bacteroides vulgatus) has a significant role in the human gut microbiome. It can produce bioactive compounds with antimicrobial properties and industrially relevant organic acids like succinate. However, there is a knowledge gap in understanding the metabolism of P. vulgatus, as cultivation of anaerobic gut bacteria is challenging and usually conducted with enriched microbiota cultures. We aim to close this gap by characterizing this anaerobe bacterium in different cultivation conditions and scales.

Methods
In this work, axenic cultures were studied in a shake flask and 2 L fermenter scale to characterize the influence of initial pH, buffer concentration, osmolality, and product inhibition on growth and organic acid production by P. vulgatus. Both cultivation systems had online gas measurements for total gas and CO2 production. HPLC analysis generated closed carbon balances, accounting for all produced acids.

Results
Total gas transfer rates and CO2 transfer rates revealed that 65% of produced gas was attributed to H2, while just 35% was connected to CO2 production. A minimum buffer concentration of 50 mM MOPS and an initial pH of 7.3 were identified to mitigate pH inhibition in P. vulgatus cultivations with a defined minimal medium and glucose as substrate. The initial addition of lactate showed an inhibitory effect, starting at a concentration of 1 g L−1. On the contrary, initial acetate addition was beneficial for organic acid production. A comparison of a pH-buffered and a pH-controlled 2 L fermentation demonstrated a switch in acid production toward succinate under pH control.

Conclusion
The study provides insight into improved cultivation conditions for the gut bacterium P. vulgatus and demonstrates a successful scale-up from the shake flask to the 2 L bioreactor. By applying pH control in the bioreactor, growth was increased, and the organic acid production was switched from lactate to succinate. Even though P. vulgatus could serve as a production organism for interesting bioactive compounds and organic acids, further characterization and improvement are necessary to improve titers.
Burnout among family medicine residents: a cross-sectional nationwide study
Authors: Treister-Goltzman Yulia , Samson Tali , Rosenberg Reena , Granek-Catarivas Martine , Gaver Anat , Alperin Mordechai , Biderman Aya 
Published: January 2024

Abstract
Background
In addition to pressures typical of other medical professions, family physicians face additional challenges such as building long-term relationships with patients, dealing with patients' social problems, and working at a high level of uncertainty. We aimed to assess the rate of burnout and factors associated with it among family medicine residents throughout Israel.

Methods
A cross sectional study based on a self-administered questionnaire.

Results
Ninety family medicine residents throughout Israel completed the questionnaire. The rate of clinically significant burnout, assessed by the composite Shirom-Melamed Burnout Questionnaire score, was 14.4%. In univariate analyses several personal and professional characteristics, as well as all tested psychological characteristics, showed significant associations with burnout. However, in the multivariable logistic regression only psychological work-related characteristics (work engagement, psychological flexibility (reverse scoring), and perceived work-related stress) were significantly associated with burnout at OR (95% CI) = 0.23 (0.06–0.60), 1.31 (1.10–1.71), and 1.16 (1.05–3.749), respectively.

Conclusion
The integration of burnout prevention programs into academic courses during residency could explain the relatively low prevalence of burnout among family medicine residents in this study. Given the strong association of burnout with psychological characteristics, further investment in burnout prevention through targeted structured courses for residents should be encouraged.
Contraceptive dynamics among women with disabilities of reproductive age in Ethiopia: systematic review
Authors: Anshebo Abebe Alemu , Markos Yilma , Behera Sujit , Gopalan Natarajan 
Published: January 2024

Abstract
Background
In low-income countries, women with disabilities have limited access to essential sexual and reproductive health services and are disadvantaged socioeconomically. Even though some studies have been conducted previously, there are scanty findings on contraceptive use and associated factors among women with disabilities. Thus, this systematic review aimed to assess contraceptive use and associated factors among women with disabilities of reproductive age in Ethiopia.

Methods
The Preferred Reporting Item for Systematic Review and Meta-Analyses [PRISMA] guidance is used to conduct this systematic review. Data were searched from electronic databases: PubMed/Medline, Scopus, Google Scholar, and other relevant sources. Studies screening was done using Rayyan software. The findings were narratively synthesized using a socio-ecological framework for health promotion.

Result
Ten cross-sectional studies and 4436 women with disabilities of reproductive age were included in this review. According to this review, women with disabilities are less likely to use contraceptives, with a prevalence of 21.7% in Gondor City and 44.4% in Addis Ababa. The associated factors were identified and themed at individual, interpersonal, community, and institutional levels.

Conclusion
Overall, the review findings revealed that women with disabilities continue to encounter challenges ranging from individual level to disability-unfriendly health facility infrastructure or institutional level. Therefore, health professionals and other relevant stakeholders should draw attention to creating awareness towards contraceptive use at individual and interpersonal levels, ensuring accessible contraceptive services and disability-friendly health facilities.
Diet and monensin influence the temporal dynamics of the rumen microbiome in stocker and finishing cattle
Authors: Chai Jianmin , Weiss Caleb P. , Beck Paul A. , Zhao Wei , Li Ying , Zhao Jiangchao 
Published: January 2024

Abstract
Background
Stocker cattle diet and management influence beef cattle performance during the finishing stage, but knowledge of the dynamics of the rumen microbiome associated with the host are lacking. A longitudinal study was conducted to determine how the feeding strategy from the stocker to the finishing stages of production affects the temporal dynamics of rumen microbiota. During the stocker phase, either dry hay or wheat pasture were provided, and three levels of monensin were administrated. All calves were then transported to a feedlot and received similar finishing diets with or without monensin. Rumen microbial samples were collected on d 0, 28, 85 during the stocker stage (S0, S28 and S85) and d 0, 14, 28, 56, 30 d before slaughter and the end of the trial during the finishing stage (F0, F14, F28, F56, Pre-Ba, and Final). The V4 region of the bacterial 16S rRNA gene of 263 rumen samples was sequenced.

Results
Higher alpha diversity, including the number of observed bacterial features and the Shannon index, was observed in the stocker phase compared to the finishing phase. The bacterial amplicon sequence variants (ASVs) differentiating different sampling time points were identified. Dietary treatments during the stocker stage temporally impact the dynamics of rumen microbiota. For example, shared bacteria, including Bacteroidales (ASV19) and Streptococcus infantarius (ASV94), were significantly higher in hay rumen on S28, S85, and F0, while Bacteroidaceae (ASV11) and Limivicinus (ASV15) were more abundant in wheat. Monensin affected rumen microbial composition at a specific time. Transportation to feedlot significantly influenced microbiome structure and diversity in hay-fed calves. Bacterial taxa associated with body weight were classified, and core microbiotas interacted with each other during the trial.

Conclusions
In summary, the temporal dynamics of the rumen microbiome in cattle at the stocker and finishing stage are influenced by multiple factors of the feeding strategy. Diet at the stocker phase may temporarily affect the microbial composition during this stage. Modulating the rumen microbiome in the steers at the stocker stage affects the microbial interactions and performance in the finishing stage.
Autotrophic biofilms sustained by deeply sourced groundwater host diverse bacteria implicated in sulfur and hydrogen metabolism
Authors: Valentin-Alvarado Luis E. , Fakra Sirine C. , Probst Alexander J. , Giska Jonathan R. , Jaffe Alexander L. , Oltrogge Luke M. , West-Roberts Jacob , Rowland Joel , Manga Michael , Savage David F. , Greening Chris , Baker Brett J. , Banfield Jillian F. 
Published: January 2024

Abstract
Background
Biofilms in sulfide-rich springs present intricate microbial communities that play pivotal roles in biogeochemical cycling. We studied chemoautotrophically based biofilms that host diverse CPR bacteria and grow in sulfide-rich springs to investigate microbial controls on biogeochemical cycling.

Results
Sulfide springs biofilms were investigated using bulk geochemical analysis, genome-resolved metagenomics, and scanning transmission X-ray microscopy (STXM) at room temperature and 87 K. Chemolithotrophic sulfur-oxidizing bacteria, including Thiothrix and Beggiatoa, dominate the biofilms, which also contain CPR Gracilibacteria, Absconditabacteria, Saccharibacteria, Peregrinibacteria, Berkelbacteria, Microgenomates, and Parcubacteria. STXM imaging revealed ultra-small cells near the surfaces of filamentous bacteria that may be CPR bacterial episymbionts. STXM and NEXAFS spectroscopy at carbon K and sulfur L2,3 edges show that filamentous bacteria contain protein-encapsulated spherical elemental sulfur granules, indicating that they are sulfur oxidizers, likely Thiothrix. Berkelbacteria and Moranbacteria in the same biofilm sample are predicted to have a novel electron bifurcating group 3b [NiFe]-hydrogenase, putatively a sulfhydrogenase, potentially linked to sulfur metabolism via redox cofactors. This complex could potentially contribute to symbioses, for example, with sulfur-oxidizing bacteria such as Thiothrix that is based on cryptic sulfur cycling. One Doudnabacteria genome encodes adjacent sulfur dioxygenase and rhodanese genes that may convert thiosulfate to sulfite. We find similar conserved genomic architecture associated with CPR bacteria from other sulfur-rich subsurface ecosystems.

Conclusions
Our combined metagenomic, geochemical, spectromicroscopic, and structural bioinformatics analyses of biofilms growing in sulfide-rich springs revealed consortia that contain CPR bacteria and sulfur-oxidizing Proteobacteria, including Thiothrix, and bacteria from a new family within Beggiatoales. We infer roles for CPR bacteria in sulfur and hydrogen cycling.
Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry
Authors: Nishikimi Mitsuaki , Ohshimo Shinichiro , Fukumoto Wataru , Hamaguchi Jun , Matsumura Kazuki , Fujizuka Kenji , Hagiwara Yoshihiro , Nakayama Ryuichi , Bunya Naofumi , Maruyama Junichi , Abe Toshikazu , Anzai Tatsuhiko , Ogata Yoshitaka , Naito Hiromichi , Amemiya Yu , Ikeda Tokuji , Yagi Masayuki , Furukawa Yutaro , Taniguchi Hayato , Yagi Tsukasa , Katsuta Ken , Konno Daisuke , Suzuki Ginga , Kawasaki Yuki , Hattori Noriyuki , Nakamura Tomoyuki , Kondo Natsuki , Kikuchi Hitoshi , Kai Shinichi , Ichiyama Saaya , Awai Kazuo , Takahashi Kunihiko , Shime Nobuaki ,   J-CARVE registry group, Ishii Junki , Ogura Takayuki , Nakamura Mitsunobu , Shimizu Keiki , Shimatani Tatsutoshi , Masuda Mamoru 
Published: January 2024

Abstract
Background
Chest computed tomography findings are helpful for understanding the pathophysiology of severe acute respiratory distress syndrome (ARDS). However, there is no large, multicenter, chest computed tomography registry for patients requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO). The aim of this study was to describe chest computed tomography findings at V-V ECMO initiation and to evaluate the association between the findings and outcomes in severe ARDS.

Methods
This multicenter, retrospective cohort study enrolled patients with severe ARDS on V-V ECMO, who were admitted to the intensive care units of 24 hospitals in Japan between January 1, 2012, and December 31, 2022.

Results
The primary outcome was 90-day in-hospital mortality. The secondary outcomes were the successful liberation from V-V ECMO and the values of static lung compliance. Among the 697 registry patients, of the 582 patients who underwent chest computed tomography at V-V ECMO initiation, 394 survived and 188 died. Multivariate Cox regression showed that traction bronchiectasis and subcutaneous emphysema increased the risk of 90-day in-hospital mortality (hazard ratio [95% confidence interval] 1.77 [1.19–2.63], p = 0.005 and 1.97 [1.02–3.79], p = 0.044, respectively). The presence of traction bronchiectasis was also associated with decreased successful liberation from V-V ECMO (odds ratio: 0.27 [0.14–0.52], p < 0.001). Lower static lung compliance was associated with some chest computed tomography findings related to changes outside of pulmonary opacity, but not with the findings related to pulmonary opacity.

Conclusions
Traction bronchiectasis and subcutaneous emphysema increased the risk of 90-day in-hospital mortality in patients with severe ARDS who required V-V ECMO.
Portal vein wedge resection and patch venoplasty with autologous vein grafts for hepatobiliary–pancreatic cancer
Authors: Asaoka Tadafumi , Furukawa Kenta , Mikamori Manabu , Hyuga Satoshi , Ohashi Tomofumi , Kazuya Iwamoto , Nakahara Yujiro , Naito Atsushi , Takahashi Hidekazu , Moon Jeongho , Imasato Mitsunobu , Matsuda Chu , Nishikawa Kazuhiro , Mizushima Tsunekazu 
Published: January 2024

Abstract
Background
Advanced hepatobiliary–pancreatic cancer often invades critical blood vessels, including the portal vein (PV) and hepatic artery. Resection with tumor-free resection margins is crucial to achieving a favorable prognosis in these patients. Herein, we present our cases and surgical techniques for PV wedge resection with patch venoplasty using autologous vein grafts during surgery for pancreatic ductal adenocarcinoma (PDAC) and perihilar cholangiocarcinoma (PhCC).

Case presentation
Case 1: 73-year-old female patient with PDAC; underwent subtotal stomach-preserving pancreatoduodenectomy, with superior mesenteric vein wedge resection and venoplasty with the right gonadal vein. Case 2: 67-year-old male patient with PDAC; underwent distal pancreatectomy and celiac axis resection, with PV wedge resection and venoplasty with the middle colic vein. Case 3: 51-year-old female patient with type IV PhCC; underwent left hepatectomy with caudate lobectomy and bile duct resection, with hilar PV wedge resection and venoplasty with the inferior mesenteric vein (IMV). Case 4: 69-year-old male patient with type IIIA PhCC; underwent right hepatopancreatoduodenectomy, with hilar PV resection and patch venoplasty with the IMV. All patients survived for over 12 months after the surgery, without local recurrence.

Conclusions
PV wedge resection and patch venoplasty is a useful technique for obtaining tumor-free margins in surgeries for hepatobiliary–pancreatic cancer.
RETRACTED ARTICLE: Wildfire risk exploration: leveraging SHAP and TabNet for precise factor analysis
Authors: Qayyum Faiza , Jamil Harun , Alsboui Tariq , Hijjawi Mohammad 
Published: January 2024

Abstract
Background
Understanding the intricacies of wildfire impact across diverse geographical landscapes necessitates a nuanced comprehension of fire dynamics and areas of vulnerability, particularly in regions prone to high wildfire risks. Machine learning (ML) stands as a formidable ally in addressing the complexities associated with predicting and mapping these risks, offering advanced analytical capabilities. Nevertheless, the reliability of such ML approaches is heavily contingent on the integrity of data and the robustness of training protocols. The scientific community has raised concerns about the transparency and interpretability of ML models in the context of wildfire management, recognizing the need for these models to be both accurate and understandable. The often-opaque nature of complex ML algorithms can obscure the rationale behind their outputs, making it imperative to prioritize clarity and interpretability to ensure that model predictions are not only precise but also actionable. Furthermore, a thorough evaluation of model performance must account for multiple critical factors to ensure the utility and dependability of the results in practical wildfire suppression and management strategies.

Results
This study unveils a sophisticated spatial deep learning framework grounded in TabNet technology, tailored specifically for delineating areas susceptible to wildfires. To elucidate the predictive interplay between the model’s outputs and the contributing variables across a spectrum of inputs, we embark on an exhaustive analysis using SHapley Additive exPlanations (SHAP). This approach affords a granular understanding of how individual features sway the model’s predictions. Furthermore, the robustness of the predictive model is rigorously validated through 5-fold cross-validation techniques, ensuring the dependability of the findings. The research meticulously investigates the spatial heterogeneity of wildfire susceptibility within the designated study locale, unearthing pivotal insights into the nuanced fabric of fire risk that is distinctly local in nature.

Conclusion
Utilizing SHapley Additive exPlanations (SHAP) visualizations, this research meticulously identifies key variables, quantifies their importance, and demystifies the decision-making mechanics of the model. Critical factors, including temperature, elevation, the Normalized Difference Vegetation Index (NDVI), aspect, and wind speed, are discerned to have significant sway over the predictions of wildfire susceptibility. The findings of this study accentuate the criticality of transparency in modeling, which facilitates a deeper understanding of wildfire risk factors. By shedding light on the significant predictors within the models, this work enhances our ability to interpret complex predictive models and drives forward the field of wildfire risk management, ultimately contributing to the development of more effective prevention and mitigation strategies.
Effect of combining social rhythm therapy to treatment of bipolar disorder versus treatment as usual: a comparative study on a sample of Egyptian patients
Authors: Darwish Esraa , Mubarak Ahmed , Eissa Mai , Amer Reham 
Published: January 2024

Abstract
Background
Bipolar disorder (BD) is a common mental illness that is usually associated with significant morbidity causing critical impairment in socio-occupational functioning and even mortality. Social rhythm therapy (SRT) has been suggested as an adjunctive psychotherapy in BD treatment protocols, with its proposed benefits of accelerating recovery from bipolar episodes, delaying relapses, and upgrading patients’ functioning. This study aimed to investigate the outcomes of combining SRT with pharmacological treatment, as compared to pharmacotherapy alone, in a sample of Egyptian BD patients. Sixty eligible bipolar patients were enrolled in this comparative study by convenience sampling and randomly divided into two groups for comparison; group I included 30 BD-I patients treated as usual (TAU) with pharmacological treatment only, while group II included 30 BD patients treated with social rhythm therapy in addition to the traditional psychotropic medications. Manic and depressive symptoms as well as socio-occupational functioning were assessed at baseline and after 3 months of treatment using the Mood Disorder Questionnaire (MDQ), Hamilton Depression Rating Scale (HDRS), and Socio-occupational Functioning Assessment Scale (SOFAS).

Results
Patients treated with SRT therapy showed significant improvement in their manic and depressive symptoms as well as socio-occupational functioning after 3 months of treatment by 65.76%, 55.87%, and 52.5%, respectively. Linear regression analysis showed that the gender and age of the patient could significantly predict improvement of MDQ% in group II, while none of the studied variables could significantly predict the percentage of change in HDRS or SOFAS.

Conclusion
SRT could be a promising adjunctive therapy promoting early recovery of BD patients compared to standalone pharmacological treatment.