bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Midpalatal Suture and its Correlation with the Cervical Vertebral Maturation Stages and Second Molar Mineralization Stages: A CBCT Study
Authors: Munusamy Naveen , Tandon Pradeep , Singh Gyan , Singh Gulshan , Nagar Amit , Patil Ranjit 
Published: December 2023

Objectives To evaluate and correlate the maturation stage of the midpalatal suture, CVM stages, mandibular left second molar mineralization stages of the subjects by CBCT. Materials and Methods One hundred subjects (55 males and 45 females) with a mean age of 13.56 ± 4.46 years, were divided into five midpalatal suture maturational stage groups (A to E). Cervical vertebral maturational stages on lateral cephalograms and second molar mineralization stages on orthopantograms from the CBCT images obtained from Carestream CS 9300C 3D system were analyzed and correlation among them were calculated by Spearman’s coefficient of correlation and midpalatal suture maturation stage prediction accuracy estimated with sensitivity, specificity, positive predictive value, and likelihood ratio. Results Spearman’s correlation analysis showed a highly significant ( p value < .001) and positive correlation between MPS stage and CVM Stage ( r = 0.930), MPS stage and mandibular left second molar mineralization stage ( r = 0.757), and CVM stage and mandibular left second molar mineralization stage ( r = 0.760). Conclusion Cervical vertebral maturation stages 1,2, and 3 can be used clinically to predict the midpalatal suture maturation stages A, B, and C, respectively, as their likelihood ratios were more than 10. Second molar mineralization stages had less predictive value for MPS stages.
Chinatowns: Indirect Casualties of the Pandemic
Authors: Hu Yunshu , Zhang Tianyi , Zhuang Yuerong 
Published: December 2023

The COVID-19 pandemic greatly reduced business activities, yet the negative effect was not homogeneous. We study how sentiment towards China in US major cities impact their Chinatown visits, utilizing mobility data at the census tract level and sentiment analysis from ProQuest news articles. Difference-in-difference analysis indicates that the Chinatowns in cities where the COVID-related new articles generally expressing negative sentiment towards China experienced a greater reduction in the number of visits. The result is corroborated by a placebo test that examines the number of visits to Little Italy, another type of ethnic neighborhood whose visits do not seem to be influenced by the sentiment towards China. The disparity in Chinatown visits persists across various sentiment measurement methods and varies by demographic group. JEL Codes: I1, R1
Increased Rate of Familial Mediterranean Fever in Children With ADHD: A Population-Based Case-Control Study
Authors: Merzon Eugene , Israel Ariel , Krone Beth , Medvejer Shani , Cohen Shira , Green Ilan , Golan-Cohen Avivit , Vinker Shlomo , Faraone Stephen V. , Newcorn Jeffrey H. , Ashkenazi Shai , Weizman Abraham , Manor Iris 
Published: December 2023

Objective: There is growing evidence of involvement of inflammatory mechanisms in ADHD. Previous studies found significantly higher rates of ADHD among children with FMF. The present study examined the rate of exposure to FMF in children with a later (within a 5-year period) diagnosis of ADHD compared to non-ADHD children. Methods: A population-based case-control study of all children (<18 years) registered in Leumit Health Services during 01.01.2006 to 06.30.2021. All cases met ICD-9/10 criteria for ADHD. They were matched by age, sex, and socioeconomic status on a 1:2 rate to randomly selected non-ADHD controls. Results: Fifty-six (0.30%) children with ADHD ( N = 18,756) were previously diagnosed with FMF compared to 65 of 37,512 controls (0.17%). A significant, independent association existed between a preceding FMF diagnosis and a later ADHD diagnosis [OR = 1.72 (95% CI 1.18–2.51); p = .003]. Conclusions: The mechanisms underlying the association w between FMF and later ADHD diagnosis merit further elucidation.
Interventions for mitigating occupational stress for professional dementia caregivers in residential aged care: A systematic review with meta-analysis
Authors: Antipas Hayley , Tamplin Jeanette , Vieira Sousa Tanara , Baker Felicity A. 
Published: December 2023

Objective Occupational stress in professional dementia caregivers in residential aged care facilities has adverse effects on care quality, caregivers’ health, and workforce sustainability. The purpose of this study was to examine the evidence regarding interventions to mitigate occupational stress for this population. Methods A systematic review of CINAHL, PsycINFO, PubMed and MEDLINE databases was conducted to identify original RCT research reporting on stress interventions, published in English between 1995 and March 2022. Search results were screened by two independent reviewers. Quality and risk of bias were appraised using the Downs and Black Checklist and Risk of Bias by two reviewers. Meta-analysis and subgroup analysis examined the pooled intervention effects on stress compared to control. Results 10 studies met the inclusion criteria, and these reported on 15 interventions and 28 outcomes from 92 facilities, involving 1,397 caregivers. We found a small and insignificant effect of interventions on caregiver stress (g = −.27, p = .16). Heterogeneity was partially explained by subgroup analysis. Interventions can mitigate stress and burden not attributed to client behaviour ( n = 3) (g = −.85, p < .001), and improve caregivers’ self-efficacy ( n = 4) (g = −.35, p = .07). We were unable to determine the most effective type of intervention, although organisation focused interventions showed the greatest potential (g = −.58, p = .08). Conclusion Interventions that improve caregivers’ personal and organisational resources can reduce non-client associated stress and burden and increase self-efficacy. Aged care providers are recommended to prioritise education with organisational support interventions. Research on longitudinal effects and high-risk caregivers is required. Limitations are discussed. Prospero Registration Number CRD42022313715 (registered April 2022).
An extremely rare case of recurrent pleomorphic myxoidliposarcoma with response to eribulin chemotherapy – A case report
Authors: Rao Raghavendra , Rastogi Sameer , Kashyap Divya , Shamim Shamim A , Barwad Adarsh 
Published: December 2023

Pleomorphic myxoid liposarcoma (PML) is a newly recognized entity with aggressive clinical behavior and a tendency to recur. It has histological features of both myxoid and pleomorphic liposarcoma and lacks the molecular and structural chromosomal abnormalities associated with myxoid and pleomorphic liposarcoma. The data about their response to chemotherapy is quite sparse. We report a case of incidentally detected pleomorphic myxoid liposarcoma of the mediastinum in a 32-year-old gentleman. After resection and adjuvant chemotherapy with doxorubicin and ifosfamide, there was no evidence of residual disease at the end of treatment. During a routine follow-up 5 months later, he was found to have a recurrence of the disease with histological confirmation. He received a trabectedin given its activity in myxoid liposarcoma. However, he had toxicities and progression leading to its discontinuation. Subsequently, eribulin was started as the next line of therapy. After 4 cycles of chemotherapy, response assessment was suggestive of partial response, which is still maintained after 7 cycles of eribulin. This is the first report of this entity responding to a newer chemotherapy regimen.
Pinostrobin attenuates azoxymethane-induced colorectal cytotoxicity in rats through augmentation of apoptotic Bax/Bcl-2 proteins and antioxidants
Authors: Ali Abed Wahab Bassam , Ain Salehen Nur , Abdulla Mahmood Ameen , A.j. Jabbar Ahmed , Abdel Aziz Ibrahim Ibrahim , Almaimani Ghassan , AbdulMonam Zainel Mustafa , Bamagous Ghazi A , Almaimani Riyad A , Almasmoum Hussain A , Ghaith Mazen M , Farrash Wesam F , Almutawif Yahya A 
Published: December 2023

Objectives: Pinostrobin (5-hydroxy-7-methoxyflavanone; PN) is a natural active ingredient with numerous biological activities extensively utilized in tumour chemotherapy. The present study investigates the chemo-preventive potentials of PN on azoxymethane-mediated colonic aberrant crypt foci in rats. Methods: Sprague Dawley rats clustered into five groups, normal control (A) and cancer controls were subcutaneously injected with normal saline and 15 mg/kg azoxymethane, respectively, and nourished on 10% tween 20 and fed on 10% tween 20; reference control (C), injected with 15 mg/kg azoxymethane and injected (intraperitoneal) with 35 mg/kg 5-fluorouracil (5-FU); D and E rat groups received a subcutaneous injection of 15 mg/kg azoxymethane and nourished on 30 and 60 mg/kg of PN, respectively. Results: The acute toxicity trial showed a lack of any abnormal signs or mortality in rats ingested with 250 and 500 mg/kg of PN. The gross morphology of colon tissues revealed significantly lower total colonic aberrant crypt foci incidence in PN-treated rats than that of cancer controls. Histological examination of colon tissues showed increased aberrant crypt foci availability with bizarrely elongated nuclei, stratified cells and higher depletion of the submucosal glands in cancer controls. PN treatment caused positive modulation of apoptotic (Bax and Bcl-2) proteins and inflammatory cytokines (TNF-α, IL-6 and IL-10). Moreover, rats fed on PN had significantly higher antioxidants (superoxide dismutase) and lower malondialdehyde concentrations in their colon tissue homogenates. Conclusion: The chemoprotective efficiency of PN against azoxymethane-induced aberrant crypt foci is shown by lower aberrant crypt foci values and higher aberrant crypt foci inhibition percentage, possibly through augmentation of genes responsible for apoptotic cascade and inflammations originating from azoxymethane oxidative stress insults.
Pattern and outcome of acute organophosphate poisoning at health facilities of Harari Region, Eastern Ethiopia
Authors: Tadesse Barkot , Kibret Haregeweyn , Heluf Helina , Mesfin Sinetibeb , Alemu Yordanos 
Published: December 2023

Introduction: Pesticides are frequently used by plant cultivars to control pests that could affect yield. Although many local farmers in Eastern Ethiopia use organophosphate insecticides extensively for the production of khat, the pattern and treatment outcome of acute poisoning of these organophosphates has been poorly quantified and reported in this region. Materials and Method: A cross-sectional study design was employed at two public hospitals found in Harari region, Ethiopia. The data were collected through face-to-face interviews and card review, then analyzed with SPSS version 20. Pearson’s Chi-square test was used to compare independent variables with the treatment outcome. Statistical significance is defined at 95% confidence interval of odds ratio not including 1 or p < 0.05. Results: A total of 135 cases of organophosphate were admitted in the emergency departments of the hospitals during the study period. 42.2% of participants were adolescents (age: 11–20 years) while the mean age of all participants was 18.8 ± 12.9 years with a range of 1–61 years. 73.7% of the study participants were rural residents. The result showed that 47.4% of the cases were exposed to the poison accidentally. Family disharmony was the common reason among cases poisoned intentionally. The mean time elapsed between poisoning and reaching the health facility was 3.1 h. Atropine was administered for 47% of the cases. About 11% of cases expired following the poison. The home remedy given, lag time, and residency were found to be factors significantly related to poor treatment outcomes. Conclusion: Easy availability, low cost, and excessive popularity of organophosphate use as pesticides in Eastern Ethiopia have increased the incidence of ingestion, resulting in increasing intentional and unintentional poisoning. In the present study, accidental exposure accounts for 47.4%.
Role of ICT, Governance Quality in Indirect Tax Revenue Productivity: A Comparative Analysis of Two Recent Indirect Tax Regimes in Indian States
Authors: Mallick Hrushikesh 
Published: December 2023

The study explores the determinants of indirect tax mobilization across various groups of Indian states based on their major, minor categories and more and less industrialized attributes. It observes a strongly positive but differential impact of per capita RGSDP on own tax revenue efforts of various state groups. Information and Communication Technology use is only helping major less and minor more producer states in augmenting their tax revenues, whereas it results in decreased revenues for major more and minor less producing state groups including all the states in a group. This implies use of Information and Communication Technology has been less effective for most Indian states in augmenting their tax revenues. The governance quality results in loss of tax revenues in major and minor less producer states, while it has no effect on major more producer including all minor and all states together. This implies a weak role of governance in taxation. We observe differential impact of tax regimes for different state panels, which has significant policy relevance. JEL Classification: H11, H21, H27, H77
Early neurological deterioration in patients with acute ischemic stroke is linked to unfavorable cerebral venous outflow
Authors: Heitkamp Christian , Winkelmeier Laurens , Heit Jeremy J , Albers Gregory W , Lansberg Maarten G , Kniep Helge , Broocks Gabriel , Stracke Christian Paul , Schell Maximilian , Guenego Adrien , Paech Daniel , Wintermark Max , Fiehler Jens , Faizy Tobias D 
Published: December 2023

Introduction: Early neurological deterioration (END) is associated with poor outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). Causes of END after mechanical thrombectomy (MT) include unsuccessful recanalization and reperfusion hemorrhages. However, little is known about END excluding the aforementioned causes. We aimed to investigate factors associated with unexplained END (ENDunexplained) with regard to the cerebral collateral status. Patients and Methods: Multicenter retrospective study of AIS-LVO patients with successful MT (mTICI 2b-3). On admission CT angiography (CTA), pial arterial collaterals and venous outflow (VO) were assessed using the modified Tan-Scale and the Cortical Vein Opacification Score (COVES), respectively. ENDunexplained was defined as an increase in NIHSS score of ⩾ 4 within the first 24 hours after MT without parenchymal hemorrhage on follow-up imaging. Multivariable regression analyses were performed to examine factors of ENDunexplained and unfavorable functional outcome (modified Rankin Scale score 3-6). Results: A total of 620 patients met the inclusion criteria. ENDunexplained occurred in 10% of patients. While there was no significant difference in pial arterial collaterals, patients with ENDunexplained exhibited more often unfavorable VO (81% vs. 53%; P < 0.001). Unfavorable VO (aOR [95% CI]; 2.56 [1.02-6.40]; P = 0.045) was an independent predictor of ENDunexplained. ENDunexplained was independently associated with unfavorable functional outcomes at 90 days (aOR [95% CI]; 6.25 [2.06-18.94]; P = 0.001). Discussion and Conclusion: Unfavorable VO on admission CTA was associated with ENDunexplained. ENDunexplained was independently linked to unfavorable functional outcomes at 90 days. Identifying AIS-LVO patients at risk of ENDunexplained may help to select patients for intensified monitoring and guide to optimal treatment regimes.
Characterization of microbial communities during Grifola frondosa (maitake) wood log cultivation
Authors: Chen Fu-Chia , Motoda Taichi , Kamei Ichiro , Kijidani Yoshio 
Published: December 2023

AbstractThe method used to cultivate the popular Japanese mushroom Grifola frondosa (maitake), called 'wood log cultivation', comprised two steps: (1) the mycelium is grown around a wood log in a plastic bag, and (2) the mycelium that has spread on the wood log is transferred into casing substrates in a forest. This method is still popular in Japan due to its low cost and high-quality crop production. The importance of the microbiome that inhabits mushroom-cultivation surroundings has recently attracted attention, but no study of the microbial communities in maitake cultivation has been published. We investigated how the bacterial communities changed in wood logs in comparison with a control group (without inoculation) and their interaction with maitake during the first to fourth years of maitake wood log cultivation. A maitake biomass was detected by quantitative PCR in wood logs but not in the casings, and we thus decided to investigate the bacterial communities in wood log samples for control and first- to fourth-year cultivation. The results indicate that the phyla Proteobacteria, Firmicutes, and Gemmatimonadota play key roles in changes of the microbiome composition for maitake wood log cultivation. In a functional profile, bacteria communities in the wood logs during maitake cultivation showed higher relative abundance in cellulolysis, glycolysis, TCA cycle, and many biosynthesis pathways, whereas the control group showed higher relative abundance in fermentation. These results suggested that (i) the bacterial communities which inhabited maitake cultivated wood logs may help the maitake degrade wood cellulose, and (ii) part of the glucose from the cellulose degraded by both maitake and bacteria was used for the bacterial TCA cycle instead of fermentation. Bacteria also produce some chemicals that maitake mycelium may need. It is also likely that some potential intracellular parasites dwell with maitake. The different cultivation stages showed different network structures. A network analysis indicated that Class Gammaproteobacteria is a potential keystone taxon for the microbiome network stability of maitake cultivated wood logs. These results contribute to the understanding of the microbiome in maitake-cultivation surroundings and will improve maitake wood log cultivation.
An oscillating reaction network with an exact closed form solution in the time domain
Authors: Hellerstein Joseph 
Published: December 2023

Abstract
Background
Oscillatory behavior is critical to many life sustaining processes such as cell cycles, circadian rhythms, and notch signaling. Important biological functions depend on the characteristics of these oscillations (hereafter, oscillation characteristics or OCs): frequency (e.g., event timings), amplitude (e.g., signal strength), and phase (e.g., event sequencing). Numerous oscillating reaction networks have been documented or proposed. Some investigators claim that oscillations in reaction networks require nonlinear dynamics in that at least one rate law is a nonlinear function of species concentrations. No one has shown that oscillations can be produced for a reaction network with linear dynamics. Further, no one has obtained closed form solutions for the frequency, amplitude and phase of any oscillating reaction network. Finally, no one has published an algorithm for constructing oscillating reaction networks with desired OCs.

Results
This is a theoretical study that analyzes reaction networks in terms of their representation as systems of ordinary differential equations. Our contributions are: (a) construction of an oscillating, two species reaction network [two species harmonic oscillator (2SHO)] that has no nonlinearity; (b) obtaining closed form formulas that calculate frequency, amplitude, and phase in terms of the parameters of the 2SHO reaction network, something that has not been done for any published oscillating reaction network; and (c) development of an algorithm that parameterizes the 2SHO to achieve desired oscillation, a capability that has not been produced for any published oscillating reaction network.

Conclusions
Our 2SHO demonstrates the feasibility of creating an oscillating reaction network whose dynamics are described by a system of linear differential equations. Because it is a linear system, we can derive closed form expressions for the frequency, amplitude, and phase of oscillations, something that has not been done for other published reaction networks. With these formulas, we can design 2SHO reaction networks to have desired oscillation characteristics. Finally, our sensitivity analysis suggests an approach to constructing a 2SHO for a biochemical system.
Flower color polymorphism of a wild Iris on the Qinghai-Tibet plateau
Authors: Zhou Zhi-Li , Wang Guang-Yan , Wang Xi-Long , Huang Xiao-Juan , Zhu Zhang-Shichang , Wang Lin-Lin , Yang Yong-Ping , Duan Yuan-Wen 
Published: December 2023

Abstract
Background
Flower color plays a crucial role in attracting pollinators and facilitating environmental adaptation. Investigating the causes of flower color polymorphism and understanding their potential effects on both ecology and genetics can enhance our understanding of flower color polymorphism in wild plant.

Results
In this study, we examined the differences of potential male and female fitness between purple- and yellow- flower individuals in Iris potaninii on the Qinghai-Tibet Plateau, and screened key genes and positively selective genes involved in flower color change. Our results showed that yellow flower exhibited a higher pollen-to-ovule ratio. Yellow flowers were derived from purple flowers due to the loss of anthocyanins, and F3H could be an essential gene affecting flower color variation though expression regulation and sequence polymorphism in this species. Furthermore, our findings suggest that genes positively selected in yellow-flowered I. potaninii might be involved in nucleotide excision repair and plant-pathogen interactions.

Conclusions
These results suggest that F3H induces the flower color variation of Iris potaninii, and the subsequent ecological and additive positive selection on yellow flowers may further enhance plant adaptations to alpine environments.
Diversity of Arbuscular Mycorrhizal fungi under different agroforestry practices in the drylands of Southern Ethiopia
Authors: Masebo Nebiyou , Birhane Emiru , Takele Serekebirhan , Belay Zerihun , Lucena Juan J. , Pérez-Sanz Araceli , Anjulo Agena 
Published: December 2023

AbstractThe conversion of an agroforestry based agricultural system to a monocropping farming system influences the distribution and composition of arbuscular mycorrhizal fungi (AMF). The aim of this paper was to analyze AMF species diversity, spore density, and root colonization across different agroforestry practices (AFP) in southern Ethiopia. Soil and root samples were collected from homegarden, cropland, woodlot, and trees on soil and water conservation-based AFP. AMF spores were extracted from the soil and species diversity was evaluated using morphological analysis and root colonization from root samples. The AMF spore density, root colonization and composition were significantly different among the AFP (P < 0.05). In this study, 43 AMF morphotypes belonging to eleven genera were found, dominated by Acaulospora (32.56%), followed by Claroideoglomus (18.60%). Home gardens had the highest spore density (7641.5 spore100 g− 1 dry soil) and the lowest was recorded in croplands (683.6 spore100 g− 1 dry soil). Woodlot had the highest root colonization (54.75%), followed by homegarden (48.25%). The highest isolation frequency (63.63%) was recorded for Acaulospora scrobiculata. The distribution of AMF species and diversity were significantly related to soil total nitrogen and organic carbon. The homegarden and woodlot AFP were suitable for soil AMF reserve and conservation.