bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan tentang DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) di SMPN 31 Banjarmasin
Authors: Desriyanti Anisa , Aida Nor , Intannia Difa , Rahmatullah Satrio Wibowo , Lingga Herningtyas Nautika 
Published: December 2023

Obat merupakan bahan atau paduan bahan yang digunakan untuk menyembuhkan, memelihara, dan meningkatkan kesehatan. Jika dalam penggunaan suatu obat tidak tepat, maka dapat berisiko membahayakan penggunanya. Salah satu upaya untuk menghindari terjadinya penggunaan obat yang salah atau penyalahgunaan obat dapat dilakukan promosi kesehatan DAGUSIBU yang merupakan singkatan dari (Dapatkan, Gunakan, Simpan, Buang) obat dengan tepat yang merupakan program gerakan keluarga sadar obat. Kegiatan promosi kesehatan dilakukan dengan tujuan untuk meningkatkan pengetahuan mengenai cara mendapatkan, menggunakan, menyimpan, dan membuang obat yang tepat pada siswa SMPN 31 Banjarmasin. Metode yang digunakan yaitu ceramah disertai dengan pemberian leaflet berisi materi DAGUSIBU. Sebagai bahan evaluasi dilakukan pretes, diskusi, tanya jawab dan postes. Hasil kegiatan promosi kesehatan diketahui nilai rata-rata pretes siswa adalah 65,33 dan nilai rata-rata postes siswa adalah 95. Sehingga dapat disimpulkan bahwa terdapat peningkatan pengetahuan siswa mengenai DAGUSIBU sebanyak 45,41% setelah diberikan promosi kesehatan. Kata Kunci: Leaflet, Obat, Promosi Kesehatan, Siswa Medicine is a substance i that is necessary for maintaining and enhancing health, but when taken improperly, it can be harmful to the user. DAGUSIBU (Get, Use, Save, Dispose of) drugs safely and correctly, a drug awareness family movement program, is one strategy to prevent inappropriate or overuse of drugs. In order to improve students' awareness of how to get, use, store, and dispose of medications, health promotion activities were conducted at SMPN 31 Banjarmasin. The approach employed was a lecture combined with the distribution of pamphlets providing DAGUSIBU information. Pre-test, discussion, question-and-answer, and post-test exercises were used as evaluation tools. The outcomes of the health promotion activities revealed that the typical student pretest score was 65.33 and the typical student posttest score was 95. Thus, it can be said that after receiving health promotion, students' understanding of DAGUSIBU increased by 45.41%.
A Case Report of Secondary Glaucoma in a Patient With HTLV-1-Discussion About the Management of Secondary Glaucoma Due to Recurrent Granulomatous Uveitis?
Authors: Hamanaka Teruhiko , Ashikaga Kenta , Hosogai Mayumi , Tanaka Takao , Nakao Shintaro , Funaki Toshinari 
Published: December 2023

Purpose
To investigate secondary glaucoma resulting from uveitis in a patient infected with Human T-cell Leukemia Virus Type 1 (HTLV-1) pathologically and discuss the management of glaucoma with recurrent uveitis.
Clinical course
An octogenarian woman diagnosed as a carrier of HTLV-1 experienced recurrent uveitis and a sudden rise in intraocular pressure (IOP) in both eyes. Due to the uncontrolled IOP and severely damaged visual field in her left eye, a combined procedure of trabeculectomy and DGIS (Glaucoma drainage implant surgery, Baerveldt 350) was performed. The presence of HTLV-1 provirus was detected in the aqueous humor. Her trabeculectomy sample was processed for light microscopic observation. Following an irregular follow-up, she presented with a sudden decrease in vision and pain in her fellow eye, four years after the glaucoma surgeries. Her right eye exhibited a significant accumulation of mutton-fat-like keratic precipitates.
Results
Clinical manifestations revealed the presence of granulomatous uveitis. The combined glaucoma surgery, along with continuous topical corticosteroid medication post-surgery in her left eye, effectively suppressed the high IOP spikes and the recurrence of uveitis for 4 years. The pathological examination of the outflow pathways showed a range of damages in Schlemm&#039;s canal (SC), including SC endothelial loss, narrowing, and occlusion, as well as loss of trabecular meshwork (TM) cells and fused TM beams.
Conclusion
Combined GDIS and trabeculectomy represents a promising approach for managing such refractory cases of secondary glaucoma. The continuous topical corticosteroid medication is strongly recommended to prevent irreversible changes in SC and TM associated with granulomatous uveitis.
Development of Complementary Food From Sorghum Blended With Peanut
Authors: Dol Mahamed , Mahdi Shamsedin , Mohamed Hodo 
Published: December 2023

Abstract
Improving the nutritional status of infants requires the optimum use of available food. The objective of this study was to develop a Product and Evaluate its Proximate Composition and Sensory Properties of Sorghum Blended with Peanut (SBP) For Nutritional Improvement of Sorghum Foods. To do this, the raw materials were cleaned and de-hulled before being milled. seven formulations of composites flours composed of 100% of sorghum flour and 0% of peanut flour, 92.5% of sorghum flour and 7.5% of peanut flour, 85% of sorghum flour and 15% of peanut flour, 77.5% of sorghum flour and 22.5% of peanut flour, and 70% of sorghum flour and 30% of peanut flour were produced. The technological properties and the nutritional characteristics of the composite flours were determined using AOAC methods. From the results, the water absorption capacity(WAC) of the present study, the composite flour varied between 128.15-133.96%. The results show that the mixture proportions of the sorghum and peanut have a strong linear significance (P≤ 0.01)effect on the water absorption capacity. The moisture content of the SBP sample flour ranged between 5.34 to 6.35%. Also, the mixture proportion of 70 grams of sorghum and 30 grams of peanut had the highest moisture contents compared to the other ratios of the mixture and these results indicated that increasing the peanut ratio increases the moisture content of the sample flours of the mixtures. the result indicates that the crude protein content of the SBP samples ranged between 12.53 to 17.38% of protein concentration. the highest protein (17.38%) content was observed from the ratio of 70 grams of sorghum and 30 grams of peanut flour which is assumed to be promising potential as a good source of plant protein. The crude fat content of sorghum and peanut flour recorded in this study was found in between the values of 4.40-15.61%. The total carbohydrate content ranged from 54.08% to 75.33% for all the formulations. According to the finding of the study sorghum with zero peanut ration indicated the highest carbohydrate contents and the lowest carbohydrate contents was seen with a peanut ration of 30 grams.The total energy content of sorghum flour and peanut flour was shown in. The total energy content of SBP sample flours varied from 388.86% to 423.80 kcal/100g. According to the average sensory assessments of the SBP product's color, scent, taste, mouth feel, and overall acceptability, the inclusion of peanut flours significantly changed the product's sensory attributes.
Variable impact of wildfire smoke on ecosystem metabolic rates in lakes
Authors: Smits Adrianne , Scordo Facundo , Tang Minmeng , Cortés Alicia , Farruggia Mary , Culpepper Joshua , Chandra Sudeep , Jin Yufang , Valbuena Sergio , Watanabe Shohei , Schladow Geoffrey , Sadro Steven 
Published: December 2023

Abstract

Increasingly severe wildfires release smoke plumes that cover entire continents, depositing aerosols and reducing solar radiation fluxes to millions of freshwater ecosystems, yet little is known about their impacts on inland waters. This large scale study 1) quantified annual and seasonal trends in the spatial extent of dense smoke cover in California, USA, over the last 18 years (2006–2022), and 2) assessed the impacts of dense smoke cover on daily gross primary production (GPP) and ecosystem respiration (R) in 10 lakes spanning a large gradient in nutrient concentration and water clarity, during the three smokiest years in our dataset (2018, 2020, 2021). We found that the maximum spatial extent of dense smoke cover between June-October has increased to 70% of California’s area since 2006, with the greatest increases in August and September. In the three smokiest years, lakes were exposed to an average of 33 days of dense smoke between July and October, resulting in substantial reductions in shortwave radiation fluxes and 3 to 4-fold increases in atmospheric fine particulate matter concentrations (PM2.5). However, responses of lake GPP to smoke cover were extremely variable among and within lakes, as well as between years. In contrast, the response of rates of ecosystem respiration to smoke was related to lake nutrient concentrations and water temperature –respiration rates decreased during smoke cover in cold, oligotrophic lakes but not in warm, eutrophic lakes. The impacts of dense, prolonged smoke cover on inland waters are likely to be highly variable within and among regions due to mediating effects of lake attributes and seasonal timing of wildfires.
Numerical modeling of Scholte wave propagation in acoustic-elastic coupled anisotropic media
Authors: Chen Yifei , Wang Deli , Hao Qi , Li Lingxiang 
Published: December 2023

Abstract
Numerical modeling of Scholte wave propagation is helpful for seismic exploration in deepwater environment. Scholte waves, which are generated at seafloor, exhibit distinctly different propagation behaviors than body waves in ocean-bottom seismograms. We present a staggered-grid finite-difference method of modeling Scholte wave propagation in the interface between fluid and transversely isotropic media, where the interface does not need to consider the boundary condition. We also derive the stability condition of the proposed method. Numerical examples are used to analyze the wavefield and traveltime of Scholte waves. Numerical results show that the velocity of the Scholte wave is positively correlated with ε and negatively correlated with δ. And the curve of the arrival time of the Scholte wave as a whole is sinusoidal and has no symmetry in inclination. The velocity of the Scholte wave in azimuth is positively related to the polar angle. The energy of the Scholte wave is negatively correlated with the distance from the source to the fluid-solid interface.
Applying Formal Methods to Build a Safe Continuous-Control Architecture for an Unmanned Aerial Vehicle
Authors: Becker Leandro Buss , Gonçalves Fernando Silvano , Broering Elton Ferreira , Misson Henrique Amaral , Cordeiro Lucas 
Published: December 2023

Abstract

Cyber-Physical Systems (CPS) are systems composed of computational and physical processes where constant interaction with the surrounding environment exists. Unmanned Aerial Vehicles (UAVs) can be highlighted as a typical example of CPS. It contains devices that sense the surrounding environment (e.g., IMU, GPS) and provide data for the embedded continuous-control software to compute the CPS reactions. Such reactions are, in fact, actions in the physical (electro-mechanical) process, which occur using actuators (e.g., motors' speed controllers). Such a CPS is typically classified as safety-critical because a failure might have severe implications. Therefore, providing safety guarantees is of utmost importance when designing this application. This paper presents a solution for offering safety guarantees during the design of the continuous-control architecture, which is one of the most critical parts of the CPS. The present proposal applies formal verification (FV) techniques to detect software errors and verify if the architecture is suitable to cope with the real-time requirements coming from the system specification. The first verification round targets individual elements of the architecture, especially the continuous-control algorithm. Therefore, the ESBMC model checker is used; it receives the element's source code as input and can check for a set of language-specific properties, such as memory safety and concurrency vulnerabilities. After making all the individual analyses and performing subsequent corrections, another verification process is started using the UPPAAL model checker, aiming to make the schedulability analysis of the proposed architecture. Finally, we conduct a runtime monitoring analysis using our recently developed RMLib tool. This proposal was successfully used within the design process of a UAV, where different classes of design and implementation problems were detected and further corrected, as detailed in the paper.
Gene signatures derived from transcriptomic-causal networks stratified colorectal cancer patients for effective targeted therapy
Authors: Yazdani Akram , Lenz Heinz-Josef , Pillonetto Gianluigi , Mendez-Giraldez Raul , Yazdani Azam , Sanof Hanna , Hadi Reza , Samiei Esmat , Venook Alan P , Ratain Mark J , Rashid Naim , Vincent Benjamin G , Qu Xueping , Wen Yujia , Kosorok Michael , Symmans William F , Shen John Paul Y.C. , Lee Michael S , Kopetz Scott , Nixon Andrew B , Bertagnolli Monica M , Perou Charles M , Innocenti Federico 
Published: December 2023

Abstract
Predictive and prognostic gene signatures derived from interconnectivity among genes can tailor clinical care to patients in cancer treatment. We identified gene interconnectivity as the transcriptomic-causal network by integrating germline genotyping and tumor RNA-seq data from 1,165 patients with metastatic colorectal cancer (CRC). The patients were enrolled in a clinical trial with randomized treatment, either cetuximab or bevacizumab in combination with chemotherapy. We linked the network to overall survival (OS) and detected novel biomarkers by controlling for confounding genes. Our data-driven approach discerned sets of genes, each set collectively stratify patients based on OS. Two signatures under the cetuximab treatment were related to wound healing and macrophages. The signature under the bevacizumab treatment was related to cytotoxicity and we replicated its effect on OS using an external cohort. We also showed that the genes influencing OS within the signatures are downregulated in CRC tumor vs. normal tissue using another external cohort. Furthermore, the corresponding proteins encoded by the genes within the signatures interact each other and are functionally related. In conclusion, this study identified a group of genes that collectively stratified patients based on OS and uncovered promising novel prognostic biomarkers for personalized treatment of CRC using transcriptomic causal networks.
Efficacy and safety of esketamine combined with propofol for curative endoscopic resection in colorectum: A prospective, randomized controlled trial
Authors: Ma Yimei , Wang Jiali , Yang Yuying , Yao Minmin 
Published: December 2023

Abstract

Background Curative endoscopic resection is widely used to treat colonic polyps and early stage cancers. The anesthetic strategy commonly involves the use of propofol combined with a small dose of opioids for sedation. Adverse respiratory or cardiovascular events such as hypotension often occur when attempting to achieve the necessary level of sedation. Several studies have suggested its advantages owing to the anesthetic, analgesic, and sympathomimetic properties of esketamine. However, there are no reports on curative colorectal endoscopic resection. We designed this randomized controlled trial to assess the efficacy and safety of esketamine combined with propofol for sedation in patients undergoing curative colorectal endoscopic resection. Methods A total of 166 patients who underwent curative colorectal endoscopic resection were randomly assigned to groups A (propofol + fentanyl) or E (propofol + esketamine). Ideal sedation was assessed using the MOAA/S scale and was achieved using TCI-propofol with different doses of fentanyl and esketamine. The propofol consumption and vasoactive drug dosages were recorded. Sedation-related times, adverse events, and satisfaction were recorded. Results Of the 160 patients, the total propofol consumption was significantly lower in group E (n = 81) (300 mg) than in group A (n = 79) (350 mg). Hypotension and bradycardia were significantly lower in Group E than in Group A. The groups showed no significant differences in other adverse events, induction time, recovery time, or patient or endoscopist satisfaction. Conclusion Compared to fentanyl, esketamine helps decrease propofol consumption and increases cardiovascular stability during curative colorectal endoscopic resection in American Society of Anesthesiologists Class I–III patients without affecting anesthesia, patient and endoscopist satisfaction, or other adverse events. Trial registration The study was retrospectively registered at the Chinese Clinical Trial Registry (www.chictr.org.cn; registration number: ChiCTR2300069014 on 03/03/2023).
The Effect of Late Diagnosis on Hiv Related Mortality Among Adolescents in Public Hospitals of North Showa Zone Oromiya, Ethiopia; 2022: a Retrospective Cohort Study
Authors: Gabre Misgana Kebede , Tafesse Tadesse Bekele , Geleta Leta Adugna 
Published: December 2023

Abstract
Background
Late HIV diagnosis is the most prominent cause of HIV-related mortality, and also increases the risk of transmission and spread of the disease among society. Adolescents are the most vulnerable population’s age group for HIV infection in several settings but expanding access to early HIV testing remains a challenge. Consequently, a significant proportion of adolescents are still dying of HIV-related causes and the current study aimed at assessing the effect of late HIV diagnosis on HIV-related mortality among adolescents living with HIV.
Methods
Institutional based retrospective cohort study was conducted from August 21/2022-November 21/2022 at selected public hospitals in North Showa Zone of Oromiya. All newly diagnosed HIV positive adolescent, from September 1, 2012 to August 31, 2021, were included in the study. Data was entered into Epi-data version 3.1.1 and exported to Stata version 16 for further analysis. Both bi-variable and multivariable analyses were performed using Cox proportional hazard model to compare the HIV-related mortality of early diagnosed with late diagnosed adolescents using adjusted hazard ratio at 95% confidence interval (CI).
Results
A total of 341 medical records of adolescents were included in the study, contributing an overall incidence rate of 3.15 (95% CI: 2.21–4.26) deaths per 100 persons-years of observation throughout the total follow-up period of 1173.98 person-years. Adolescents with late diagnosis of HIV had three times the higher hazard of mortality (aHR = 3.00; 95% CI: 1.22–7.37) as compared to those with early diagnosis of HIV. Adolescents within the age of 15–19 years old (aHR = 3.56; 95% CI: 1.44–8.77), rural residence (aHR = 2.81; 95% CI: 1.39–5.68), poor adherence to ART (aHR = 3.17; 95% CI: 1.49–6.76) and being anemic (aHR = 3.09; 95% CI: 1.52–6.29) were other independent predictors of HIV-related mortality
Conclusion
The study found a substantial link between late HIV diagnosis and mortality among adolescents. Residence, age, ART medication adherence, and anemia status were also found to be other independent predictors of HIV-related mortality. To achieve the ultimate aim of lowering mortality among adolescents living with HIV, rigorous emphasis must be placed on early diagnosis of the diseases. In addition, counseling on adherence and prompt diagnosis and treatment of anemia are highly recommended to reduce the mortality.
Pervasive correlations between causal disease effects of proximal SNPs vary with functional annotations and implicate stabilizing selection
Authors: Zhang Martin , Price Alkes L. , Durvasula Arun , Chiang Colby , Koch Evan , Schoech Armin , Strober Benjamin , Shi Huwenbo , Barton Alison , Kim Samuel , Weissbrod Omer , Loh Po-Ru , Gazal Steven , Sunyaev Shamil 
Published: December 2023

Abstract
The genetic architecture of human diseases and complex traits has been extensively studied, but little is known about the relationship of causal disease effect sizes between proximal SNPs, which have largely been assumed to be independent. We introduce a new method, LD SNP-pair effect correlation regression (LDSPEC), to estimate the correlation of causal disease effect sizes of derived alleles between proximal SNPs, depending on their allele frequencies, LD, and functional annotations; LDSPEC produced robust estimates in simulations across various genetic architectures. We applied LDSPEC to 70 diseases and complex traits from the UK Biobank (average N=306K), meta-analyzing results across diseases/traits. We detected significantly nonzero effect correlations for proximal SNP pairs (e.g., −0.37±0.09 for low-frequency positive-LD 0-100bp SNP pairs) that decayed with distance (e.g., −0.07±0.01 for low-frequency positive-LD 1-10kb), varied with allele frequency (e.g., −0.15±0.04 for common positive-LD 0-100bp), and varied with LD between SNPs (e.g., +0.12±0.05 for common negative-LD 0-100bp) (because we consider derived alleles, positive-LD and negative-LD SNP pairs may yield very different results). We further determined that SNP pairs with shared functions had stronger effect correlations that spanned longer genomic distances, e.g., −0.37±0.08 for low-frequency positive-LD same-gene promoter SNP pairs (average genomic distance of 47kb (due to alternative splicing)) and −0.32±0.04 for low-frequency positive-LD H3K27ac 0-1kb SNP pairs. Consequently, SNP-heritability estimates were substantially smaller than estimates of the sum of causal effect size variances across all SNPs (ratio of 0.87±0.02 across diseases/traits), particularly for certain functional annotations (e.g., 0.78±0.01 for common Super enhancer SNPs)—even though these quantities are widely assumed to be equal. We recapitulated our findings via forward simulations with an evolutionary model involving stabilizing selection, implicating the action of linkage masking, whereby haplotypes containing linked SNPs with opposite effects on disease have reduced effects on fitness and escape negative selection.
Establishment and application of a nomogram diagram for predicting calcium oxalate stones in patients with urinary tract stones
Authors: Zhu Guanhua , Jin Lichen , Guo Yinsheng , Sun Lu , Li Shiqing , Zhou Feng 
Published: December 2023

Abstract

Objective This retrospective study aims to examine the correlation between calcium oxalate (CaOx) stones and common clinical tests, as well as urine ionic composition. Additionally, we aim to develop and implement a personalized column chart model to assess the accuracy and feasibility of using column charts to predict calcium oxalate stones in patients with urinary tract stones. Methods A retrospective analysis was conducted on data from 960 patients who underwent surgery for urinary stones at the First Affiliated Hospital of Soochow University from January 1, 2010, to December 31, 2022. Among these patients, 447 were selected for further analysis based on screening criteria. Multivariate logistic regression analysis was then performed to identify the best predictive features for calcium oxalate stones from the clinical data of the selected patients. A prediction model was developed using these features and presented in the form of a nomogram graph. The performance of the prediction model was assessed using the C-index, calibration curve, and decision curve, which evaluated its discriminative power, calibration, and clinical utility, respectively. Conclusion The nomogram diagram prediction model developed in this study is effective in predicting calcium oxalate stones, which is helpful in screening and early identification of high-risk patients with calcium oxalate urinary tract stones, and may be a guide for urologists in making clinical treatment decisions.