bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of COVID-19 vaccine clinical trial discussions on the social question-and-answer site Quora
Authors: Xu Qing , McMann Tiana J. , Li Jiawei , Wenzel Christine , Mackey Tim K. 
Published: December 2023

Abstract
Introduction
Throughout the COVID-19 pandemic, underserved populations, such as racial and ethnic minorities, were disproportionately impacted by illness, hospitalization, and death. Equity in clinical trials means that the participants in clinical trials represent the people who are most likely to have the health condition and need the treatment that the trial is testing. Infodemiology approaches examining user conversations on social media platforms have the potential to elucidate specific barriers and challenges related to clinical trial participation, including among racial and ethnic minority populations.

Materials and methods
The study retrospectively collected and analyzed user question and answer posts from Quora in October 2021 using an inductive content coding approach. We also examined user’s publicly available profile metadata to identify racial and ethnic minority users to capture their experiences, attitudes, topics, and discussions of barriers to COVID-19 vaccine trials.

Results
A total of 1073 questions and 7479 answers were collected. A total of 763 questions and 2548 answers were identified as related to COVID-19 vaccine clinical trials. The majority of these online interactions focused on asking questions and sharing knowledge and opinions about COVID-19 vaccine trials, including major topics related to: (a) interpreting whether clinical trial results could be trusted; (b) questions about vaccine efficacy and safety; (c) understanding trial design, regulatory considerations, and vaccine platforms; and (d) questions about trial enrollment, length, and adequate representation. Additionally, four major barriers discussed included: (i) disagreement from users regarding whether clinical trials require representation from different racial and ethnic minorities; (ii) concerns regarding the safety of trials when participating; (iii) lack of knowledge on how to participate in a trial; and (iv) questions of whether participants could withdraw from a trial to access an approved COVID-19 vaccine.

Conclusions
Our study found active user discussions related to COVID-19 vaccine clinical trials on Quora, including those specific to minority health topics and those posted by a smaller group of self-identified racial and ethnic minority online users. Results from this study can help identify barriers to participation among the general public and underrepresented groups while also supporting the design of future outreach strategies to help with recruitment and inclusive trial participation.
Home-based high-intensity interval training improves cardiorespiratory fitness: a systematic review and meta-analysis
Authors: Tsuji Katsunori , Tsuchiya Yosuke , Ueda Hisashi , Ochi Eisuke 
Published: December 2023

AbstractBackgroundHigh-intensity interval training (HIIT) is an effective methods to improve maximal oxygen uptake. However, there is no definitive conclusion about the specific effectiveness of home-based HIIT. This review investigated the effects of home-based HIIT on cardiorespiratory fitness in a systematic review and meta-analysis.MethodsFour electronic databases were searched (PubMed, Cochran database, Web of Science, Igaku Chuo Zasshi) for studies through March 25, 2023. Eligibility criteria include randomized controlled trials of home-based HIIT in adult people regardless disease or handicaped. Comparisons were made between non-exercise controls, laboratory-based HIIT, and moderate-intensity continuous training (MICT). The primary outcome was defined as cardiorespiratory fitness and the secondary outcome was defined as patient-reported outcomes. The standardized mean difference (SMD) with 95% confidence intervals (CIs) was calculated for quantitative indices. The random-effect model was used as the pooling method.ResultsTwo hundred seven studies were identified, and 15 satisfied the inclusion criteria. The meta-analysis for cardiorespiratory fitness showed superiority of home-based HIIT to non-exercise controls (SMD 0.61, 95% CI: 0.21, 1.02). However, no significant difference in cardiorespiratory fitness was observed between home-based HIIT and lab-based HIIT (SMD: -0.35, 95%CI: -0.73, 0.03). Also, no significant difference was observed between the home-based HIIT and MICT (SMD 0.34, 95% CI: -0.05, 0.73).ConclusionThese results indicated that home-based HIIT was an effective intervention for improving cardiorespiratory fitness in healthy adults and patients. Importantly, this review found no significant differences in cardiorespiratory fitness between home-based HIIT and the group of laboratory HIIT and MICT, highlighting its comparable effectiveness and potential as a practical and valuable exercise intervention.
Efficient bandwidth extension of musical signals using a differentiable harmonic plus noise model
Authors: Grumiaux Pierre-Amaury , Lagrange Mathieu 
Published: December 2023

AbstractThe task of bandwidth extension addresses the generation of missing high frequencies of audio signals based on knowledge of the low-frequency part of the sound. This task applies to various problems, such as audio coding or audio restoration. In this article, we focus on efficient bandwidth extension of monophonic and polyphonic musical signals using a differentiable digital signal processing (DDSP) model. Such a model is composed of a neural network part with relatively few parameters trained to infer the parameters of a differentiable digital signal processing model, which efficiently generates the output full-band audio signal. We first address bandwidth extension of monophonic signals, and then propose two methods to explicitly handle polyphonic signals. The benefits of the proposed models are first demonstrated on monophonic and polyphonic synthetic data against a baseline and a deep-learning-based ResNet model. The models are next evaluated on recorded monophonic and polyphonic data, for a wide variety of instruments and musical genres. We show that all proposed models surpass a higher complexity deep learning model for an objective metric computed in the frequency domain. A MUSHRA listening test confirms the superiority of the proposed approach in terms of perceptual quality.
Transformative power production futures: citizen jury deliberations in Saskatchewan, Canada
Authors: Hurlbert Margot , Das Tanushree , Vitto Charisse 
Published: December 2023

Abstract
Background
Transforming power production systems to achieve net zero emissions and address climate change will require deep structural changes, partially dependent on community perceptions of the necessary energy transition. The article presents results from 2-day citizen juries held in four communities of Saskatchewan, Canada: Estevan, Swift Current, Regina, and Saskatoon in 2021/22 whose purpose was to determine if place attachment impacts future power production preferences and whether social learning can be achieved. Mixed research methods included a survey before and after the citizen juries and a qualitative analysis of the discussions and outputs.

Results
Research results confirm that while there are common concerns across communities about unbiased information, transparent decision-making, justice/equity concerns, and people's involvement, community-imagined energy futures can be very divergent. Not only place-based attachment, the existent industry and infrastructure surrounding the community impact preferences but also openness to learning and group dynamics contribute. Focused deliberations on the complex problem of climate change advance social learning.
The coal, oil, and gas community of Estevan supported coal, natural gas, and carbon capture and sequestration (CCS) to a substantially larger extent than other communities, even increasing their preference for coal after the citizen jury. Saskatoon chose Small Modular Reactors (SMR) as their top choice, whereas Swift Current switched from preferring natural gas to solar and SMRs.

Conclusions
The findings from the jury sessions suggest changing attitudes toward SMRs as a potential source of energy, as well as a shift from cost considerations to environmental. Future research implications could include differing methodologies and potentially partnering beyond academia. Jurors all expressed the desire for greater government leadership, urging the government to demonstrate accountability, hold large enterprises accountable, and be more proactive in bringing parties together.
Strategies of chemolithoautotrophs adapting to high temperature and extremely acidic conditions in a shallow hydrothermal ecosystem
Authors: Deng Wenchao , Zhao Zihao , Li Yufang , Cao Rongguang , Chen Mingming , Tang Kai , Wang Deli , Fan Wei , Hu Anyi , Chen Guangcheng , Chen Chen-Tung Arthur , Zhang Yao 
Published: December 2023

Abstract
Background
Active hydrothermal vents create extreme conditions characterized by high temperatures, low pH levels, and elevated concentrations of heavy metals and other trace elements. These conditions support unique ecosystems where chemolithoautotrophs serve as primary producers. The steep temperature and pH gradients from the vent mouth to its periphery provide a wide range of microhabitats for these specialized microorganisms. However, their metabolic functions, adaptations in response to these gradients, and coping mechanisms under extreme conditions remain areas of limited knowledge. In this study, we conducted temperature gradient incubations of hydrothermal fluids from moderate (pH = 5.6) and extremely (pH = 2.2) acidic vents. Combining the DNA-stable isotope probing technique and subsequent metagenomics, we identified active chemolithoautotrophs under different temperature and pH conditions and analyzed their specific metabolic mechanisms.

Results
We found that the carbon fixation activities of Nautiliales in vent fluids were significantly increased from 45 to 65 °C under moderately acidic condition, while their heat tolerance was reduced under extremely acidic conditions. In contrast, Campylobacterales actively fixed carbon under both moderately and extremely acidic conditions under 30 − 45 °C. Compared to Campylobacterales, Nautiliales were found to lack the Sox sulfur oxidation system and instead use NAD(H)-linked glutamate dehydrogenase to boost the reverse tricarboxylic acid (rTCA) cycle. Additionally, they exhibit a high genetic potential for high activity of cytochrome bd ubiquinol oxidase in oxygen respiration and hydrogen oxidation at high temperatures. In terms of high-temperature adaption, the rgy gene plays a critical role in Nautiliales by maintaining DNA stability at high temperature. Genes encoding proteins involved in proton export, including the membrane arm subunits of proton-pumping NADH: ubiquinone oxidoreductase, K+ accumulation, selective transport of charged molecules, permease regulation, and formation of the permeability barrier of bacterial outer membranes, play essential roles in enabling Campylobacterales to adapt to extremely acidic conditions.

Conclusions
Our study provides in-depth insights into how high temperature and low pH impact the metabolic processes of energy and main elements in chemolithoautotrophs living in hydrothermal ecosystems, as well as the mechanisms they use to adapt to the extreme hydrothermal conditions.
Preliminary results of the effect of music therapy treatment on anxiety, sadness, physical discomfort, mood, and quality of life in hospitalized onco-haematological patients
Authors: Martí Patricia , Fontanals Irene , Funtané Joel , Canaletas Cristina , Sierra Jorge , Rodés Mariona , Mercadal-Brotons Melissa , González Iria , Novelli Silvana 
Published: December 2023

AbstractBackgroundPhysical and psychological distress may occur in patients facing an onco-haematological diagnosis and undergoing complex therapies such as intensive chemotherapy, stem cell transplantation, and immunotherapy. Studies have shown the need for incorporating different therapeutic modalities to respond to patients’ physical and psychosocial needs.AimsThe purpose of this study was to evaluate the effectiveness of music therapy treatment on mood, anxiety, depression, and physical discomfort in hospitalized onco-haematological patients.MethodsForty patients were included in this music therapy study from November 2021 to May 2023. Treatment consisted of individual weekly music therapy sessions. Participants completed the following evaluation instruments before and after the intervention: theHospital Anxiety and Depression Scale (HADS),Profile of Mood States—Short Form A-Version (POMS-A), andEuropean Organization for Research and Treatment of Cancer-Quality of Life Core Questionnaire-30 (EORTC QLQ-C30). A three-item numerical rating scale(NRS)for anxiety, sadness, and physical discomfort was administered at the beginning and end of each session (pre-/postsession).ResultsDifferences (p < 0.05) were shown in NRS scores for anxiety, sadness, and physical discomfort before and after the music therapy sessions. Quality of life (QoL) was affected in almost all items, and patients could be anxious at a nonclinical level, but they were clinically depressed. EORTC QLQ-C30 scores for insomnia and pain related to the hospitalization process got worse after discharge.ConclusionsThe interim results of our study showed that music therapy sessions can positively change emotional distress and improve the mood of haematological patients after every session. Despite the difficulties and limitations of this study, this preliminary report contributes to a greater understanding of the potential benefits of music therapy in hospitalized onco-haematological patients.
Repressing HIF-1α-induced HDAC9 contributes to the synergistic effect of venetoclax and MENIN inhibitor in KMT2Ar AML
Authors: Ling Qing , Zhou Yutong , Qian Yu , Qian Jiejing , Zhang Yi , Wang Jinghan , Zhu Yanan , Zhou Yile , Wei Juying , Yang Chunmei , Sun Jie , Yu Wenjuan , Jin Jie , Zhang Xiang 
Published: December 2023

AbstractKMT2A-rearranged acute myeloid leukemia (KMT2Ar-AML) is an aggressive subtype of AML with poor response and prognosis. KMT2Ar-AML has been demonstrated to be sensitive to BCL2 inhibitor venetoclax (VEN), but these patients are unable to benefit from current VEN-based regimen (VEN plus azacitidine or low dose-cytarabine), so a novel and KMT2A rearrangement-specific targeting partner is required, and MENIN inhibitor (MEN1i) is a promising one. Herein, we investigated the effect and mechanism of VEN plus MEN1i in KMT2Ar-AML. Our results showed that VEN and MEN1i exhibited a striking synergistic effect in KMT2Ar-AML cell lines (in vitro), primary KMT2Ar-AML cells (ex vivo), and MOLM13 xenotransplantation model (in vivo). Furthermore, we found that VEN plus MEN1i significantly enhanced apoptotic induction in KMT2Ar-AML cell lines. VEN or MEN1i monotherapy disrupted balance of BCL-2/BCL-XL or down-regulated HOXA9/MEIS1, respectively, but these mechanisms were not further strengthened by their combination. RNA-Sequencing identified that HDAC9 was specifically repressed by VEN plus MEN1i rather than monotherapy. We demonstrated that HDAC9 was indispensable for KMT2Ar-AML proliferation and its repression contributed to proliferation inhibition of VEN plus MEN1i. Moreover, we found that hypoxia induced HDAC9 expression in KMT2Ar-AML, and VEN plus MEN1i inhibited hypoxia pathway, especially HIF-1A, and its target HDAC9. As our results indicated, VEN plus MEN1i-mediated HDAC9 down-regulation was partially dependent on HIF-1A repression in KMT2Ar-AML. Hypoxia induction sensitized KMT2Ar-AML to VEN plus MI-503-mediated proliferation inhibition and apoptosis induction. Therefore, repressing HIF-1A-induced HDAC9 contributed to the synergistic effect of VEN and MEN1i in KMT2Ar-AML.
Dispersal and grain size characteristics of the May 14, 2018 Shinmoedake eruption deposit, Kirishima Volcano, Japan, based on post-eruption field survey and meteorological datasets
Authors: Miyabuchi Yasuo , Sato Eiichi 
Published: December 2023

AbstractThis study describes the dispersal and grain size characteristics of the May 14, 2018 Shinmoedake eruption deposits of Kirishima Volcano in southern Kyushu, southwestern Japan. We discuss the eruption sequence, including the temporal variations in the behavior of the plume, by combining field and meteorological datasets. Following a magmatic activity in 2011 characterized by a substantial change in the eruption style (from subplinian eruptions to lava effusion) and subsequent vulcanian explosions, the Shinmoedake crater experienced intermittent eruptions in 2018. The May 14, 2018 eruption began at 14:44 with a vulcanian eruption, with the eruption plume rising 4500 m above the crater rim. Thereafter, it transitioned to an ash eruption; the plume height decreased gradually until the eruption ceased at 16:10. The tephra fall deposits were distributed more than 27 km to the southeast of the source crater; the mass of the tephra fall deposit was approximately 2.1 × 107 kg, calculated based on an isomass map. The deposit incidence differed between the east and west sides of the major dispersal axis. The deposits found east of the main dispersal axis were primarily composed of coarse to medium sand-sized particles with no fine fraction (fine sand to silt in size). In contrast, the deposits west of the axis were finer-grained than those east of the axis. We analyzed photographs of the eruption plume, along with the regional meteorological data and the dispersal and grain-size characteristics of the deposits, and reached the following conclusion: during the May 14, 2018 eruption, the wind directions above the Shinmoedake crater fluctuated across altitudes. The westerly winds dispersed the eruption plume that rose to a higher altitude, containing coarser tephra associated with the initial vulcanian eruption, further to the east rather than along the main axis. In contrast, a lower-altitude ash eruption plume that was rich in fine materials was dispersed westward rather than along the main axis, which was influenced by northerly winds. The findings of this study can support the analysis of similar volcanic events.
Graphical Abstract
Revascularization with BYCROSS atherectomy device- protocol of a prospective multicenter observational study
Authors: Liebetrau Dominik , Teßarek Joerg , Elger Florian , Zerwes Sebastian , Peters Viktoria , Scheurig-Münkler Christian , Hyhlik-Dürr Alexander 
Published: December 2023

Abstract
Background
The BYCROSS™ device is a novel device intended for use in atherectomy of the peripheral arterial disease (PAD). With the BYCROSS™ atherectomy system, also prolonged calcifying lesions can be treated in a minimally invasive manner, which was previously reserved for bypass surgery. The aim of this study is to collect additional clinical data on safety and performance of the BYCROSS™ from patients undergoing revascularization of severely stenotic or occluded peripheral arterial vessels with the BYCROSS™.

Methods and design
This is an investigator-initiated national prospective multicenter observational study in patients with PAD. Sixty patients (20 per center) with PAD with stenosis higher than 80% or complete occlusion (de novo or recurrent stenosis) of vessels below the aortic bifurcation (min 3 mm vessel diameter) will be recruited. Three vascular surgery centers are participating in the study. The primary efficacy endpoint is procedural success, defined as passage of the occlusion through the BYCROSS device, and safety outcomes, explicated as freedom from device-related serious adverse events (SADEs). Secondary endpoints include primary and secondary patency rates, change in Rutherford classification, and freedom from amputation at 3 and 12 months.

Discussion
The BYCROSS atherectomy system may be a novel device for the minimally invasive treatment of prolonged calcified lesions previously reserved for bypass surgery. This national prospective multicenter observational study could represent another step in demonstrating the efficancy and safety of this device for treatment of PAD.

Trial registration
#DRKS00029947 (who.int).

Protocol approval id
#22–0047(Ethics Committee at Ludwig-Maximilians-University Munich).
Role of Montelukast in modulation of response to sepsis in preterm infants: a randomized-controlled trial
Authors: El-Shehaby Nouran , El-Shahawy Heba Abdelhameed , Nasef Nehad , El-Sallab Shadia , EL-Halaby Hanan 
Published: December 2023

Abstract
Background
Since inflammatory mediators play a crucial role in the pathophysiology of neonatal sepsis. Montelukast, as an anti-inflammatory drug, could be a beneficial therapy. In searching the literature, no previous research addressed the role of Montelukast in neonatal sepsis; hence, this study aimed to explore the adjuvant role of Montelukast in regulating the inflammatory response associated with neonatal sepsis and its associated effect on the clinical outcomes.

Methods
An open-label, randomized controlled intervention trial conducted on 40 late preterm newborn infants (gestational age 340/7 to 366/7 weeks) admitted to NICU, with clinical evidence of sepsis. In the Montelukast group (n = 20), infants received oral Montelukast once daily for 10 days (infant's weight < 2 kg received 1.5 mg whereas > 2 kg received 2 mg) with antibiotics plus routine supportive care. In the routine care group (n = 20), infants received antibiotics plus routine supportive care. Primary outcome was the serum level of tumor necrosis factor (TNF) alpha at day 10 of therapy. Secondary clinical and laboratory outcomes were reported along hospital admission.

Results
Baseline characteristics were non-significantly different between both groups. After 10 days of therapy, TNF alpha level was significantly lower in the Montelukast group (80.73 ± 50.25 versus 119.54 ± 58.46; p = 0.03). There were non-significant differences between both groups regarding duration of NICU admission, antibiotics duration or modalities and duration of respiratory support. C-reactive protein didn’t differ between both groups (p = 0.256). No documented significant adverse effects of Montelukast during the study period.

Conclusions
In late preterm neonates with sepsis, 10 days of Montelukast therapy as an adjuvant to antibiotics lowered TNF alpha level without any impact on clinical outcomes.

Trial registration
The study was approved by Mansoura Faculty of Medicine institutional research board (IRB) (MS/17.06.95) and it was registered in clinical trials database (clinicaltrials.gov, ID: NCT04474327; registered July 16, 2020).