bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Year Cardiovascular Outcomes of Telmisartan in Patients With Hypertension: An Electronic Health Record-Based Cohort Study
Authors: Yum Yunjin , Kim Ju Hyeon , Joo Hyung Joon , Kim Yong Hyun , Kim Eung Ju 
Published: January 2024

Abstract

BACKGROUND
Telmisartan exhibits superior efficacy in controlling 24-h blood pressure (BP) compared with other angiotensin receptor blockers (ARBs). However, data on its cardiovascular effects in patients with hypertension are limited. This study aimed to evaluate the cardiovascular outcomes in patients taking telmisartan compared to those taking other ARBs.

METHODS
This multicenter retrospective study used data from the Korea University Medical Center database, built from electronic health records. A total of 19,247 patients taking two or more antihypertensive medications were identified. Patients prescribed telmisartan (telmisartan users) were compared with those prescribed an ARB other than telmisartan (other ARB users). The primary outcome was major adverse cardiac events (MACE), a composite of cardiovascular death, myocardial infarction, stroke, and hospitalizations due to heart failure. The adjusted outcomes were compared using 1:1 propensity score (PS) matching.

RESULTS
Overall, 3,437 (17.9%) patients were telmisartan users. These patients were more likely to be younger and male and less likely to have a history of chronic kidney disease, dialysis, or heart failure. In the PS-matched cohort, BP control was similar in both groups; however, telmisartan users exhibited significantly lower visit-to-visit BP variability. The adjusted 3-year MACE rate was similar between telmisartan users (4.6%) and other ARB users (4.7%, log-rank P = 0.75), with comparable safety profiles.

CONCLUSIONS
In real-world practice, telmisartan showed cardiovascular outcomes similar to those of other ARBs in patients with hypertension taking two or more antihypertensive drugs.
Mating environments mediate the evolution of behavioral isolation during ecological speciation
Authors: Barerra Tania S , Sattolo Marie-Laure , Kwok Kevin E , Agrawal Aneil F , Rundle Howard D 
Published: January 2024

Abstract
The evolution of behavioral isolation is often the first step toward speciation. While past studies show that behavioral isolation will sometimes evolve as a by-product of divergent ecological selection, we lack a more nuanced understanding of factors that may promote or hamper its evolution. The environment in which mating occurs may be important in mediating whether behavioral isolation evolves for two reasons. Ecological speciation could occur as a direct outcome of different sexual interactions being favored in different mating environments. Alternatively, mating environments may vary in the constraint they impose on traits underlying mating interactions, such that populations evolving in a “constraining” mating environment would be less likely to evolve behavioral isolation than populations evolving in a less constraining mating environment. In the latter, mating environment is not the direct cause of behavioral isolation but rather permits its evolution only if other drivers are present. We test these ideas with a set of 28 experimental fly populations, each of which evolved under one of two mating environments and one of two larval environments. Counter to the prediction of ecological speciation by mating environment, behavioral isolation was not maximal between populations evolved in different mating environments. Nonetheless, mating environment was an important factor as behavioral isolation evolved among populations from one mating environment but not among populations from the other. Though one mating environment was conducive to the evolution of behavioral isolation, it was not sufficient: assortative mating only evolved between populations adapting to different-larval environments within that mating environment, indicating a role for ecological speciation. Intriguingly, the mating environment that promoted behavioral isolation is characterized by less sexual conflict compared to the other mating environment. Our results suggest that mating environments play a key role in mediating ecological speciation via other axes of divergent selection.
Sexual cannibalism as a female resistance trait: a new hypothesis
Authors: Burke Nathan W 
Published: January 2024

Abstract
Female spiders and praying mantises are renowned for their cannibalism of male partners before, during, or after mating. While several hypotheses have been proposed to explain species-specific examples of sexual cannibalism, much variation remains unexplained, including why the timing of cannibalism varies across taxa. Here, I outline how sexually cannibalistic behavior could evolve via sexually antagonistic selection as a type of behavioral resistance to male-imposed mating costs, and how such a generalizable interpretation provides a framework for understanding the evolution of both sexual cannibalism in females and anti-cannibalistic traits in males. I discuss how differences between mating systems that physiologically constrain males to mate only once (monogyny) or twice (bigyny) and systems where the sexes can potentially mate multiply (polygyny and polyandry) are likely to influence how sexual conflict shapes cannibalistic behavior. I review key examples from the literature that suggest how sexually cannibalistic behavior might function as a female resistance trait and provide comprehensive predictions for testing this hypothesis empirically.
Navigating addiction treatment during COVID-19: policy insights from state health leaders
Authors: White Sarah A , McCourt Alexander D , Tormohlen Kayla N , Yu Jiani , Eisenberg Matthew D , McGinty Emma E 
Published: January 2024

Abstract
To mitigate pandemic-related disruptions to addiction treatment, US federal and state governments made significant changes to policies regulating treatment delivery. State health agencies played a key role in implementing these policies, giving agency leaders a distinct vantage point on the feasibility and implications of post-pandemic policy sustainment. We interviewed 46 state health agency and other leaders responsible for implementing COVID-19 addiction treatment policies across 8 states with the highest COVID-19 death rate in their census region. Semi-structured interviews were conducted from April through October 2022. Transcripts were analyzed using summative content analysis to characterize policies that interviewees perceived would, if sustained, benefit addiction treatment delivery long-term. State policies were then characterized through legal database queries, internet searches, and analysis of existing policy databases. State leaders viewed multiple pandemic-era policies as useful for expanding addiction treatment access post-pandemic, including relaxing restrictions for telehealth, particularly for buprenorphine induction and audio-only treatment; take-home methadone allowances; mobile methadone clinics; and out-of-state licensing flexibilities. All states adopted at least 1 of these policies during the pandemic. Future research should evaluate these policies outside of the acute COVID-19 pandemic context.
Thermo-economic analysis of an enhanced gekothermal system for power generation based on organic Rankine cycle
Authors: Zhao Yuan , Gao Jun , Zheng Yingxia , Zhu Bo , Luo Guanqun , Tang Yuanjun , Ye Chao 
Published: January 2024

Abstract
The enhanced geothermal system (EGS) has been regarded as a promising means to exploit the abundant and low-carbon hot dry rock geothermal resources. In this work, two-stage EGSs with/without one-stage recuperative cycle for power generation based on organic Rankine cycle (ORC) were proposed, and their thermo-economic performance was evaluated, comparing to the one-stage EGS-ORC. The recuperative cycle improved the thermal performance of two-stage EGS and it had the highest thermal efficiency of 16.48%. Intermediate pressure and steam extraction ratio were important parameters that impacted the thermal performance of the two-stage EGS. The higher thermal efficiency was achieved at the intermediate pressure of 0.22 MPa and steam extraction ratio of 0.1. The two-stage EGS with one-stage recuperative cycle also had the lowest levelized cost of energy (LCOE) of $0.1895 kWh−1. According to the sensitivity analysis, the temperature of hot water and prices of electricity had the greatest impact on LCOE. The LCOE could be as low as $0.1704 kWh−1 if the temperature of hot water was 165.33 C. On the other hand, if the temperature of hot water was 149.58°C, the LCOE would be increased to $0.2179 kWh−1. The results from this study could provide the possible strategies to improve the overall thermo-economic performance of EGS-ORC.
Energy, and environmental investigation of a hybrid gas turbine–solar energy for desalination process for using in sport stadiums
Authors: Liu Xiangyou , Fei Cheng , Yao Yuzhong , Aladdin Morteza , Su Zhanguo 
Published: January 2024

Abstract
Fossil fuels are currently the primary source of electricity, but their limited supply and environmental impact have led to increased interest in renewable energies, particularly solar energy. Solar energy can be converted into electricity through photovoltaic or concentrated solar power plants, with the latter using thermal energy from concentrated solar radiation and divided into four types of concentrators. Due to the particularity of sports, large stadiums are often equipped with independent hot water preparation systems for the convenience of sports enthusiasts. Solar energy is expensive and unreliable for producing continuous electricity, but a solution is to use Solar–fossil hybrid power plants, particularly combined gas–solar turbine power plants. In these plants, concentrated solar energy heats compressed air before it enters the combustion chamber, and the rest of the energy is provided by fossil fuels, with gas power plants being the best option due to their reliability, quick start and stop, complete energy dispatching and no water consumption. The study simulated a combined gas–solar turbine power plant with a dehumidifier–humidification dehumidifier and investigated various parameters such as fuel consumption, turbine production, efficiency, solar fraction and carbon dioxide gas emission. The simulation of a combined gas–solar turbine power plant showed a decrease in fuel consumption and 45–50% of required energy provided by solar energy, with a reduction in carbon dioxide emissions by 47%.
Non-Strict Plurisubharmonicity of Energy on Teichmüller Space
Authors: Tošić Ognjen 
Published: January 2024

Abstract
For an irreducible representation $\rho :\pi _{1}(\Sigma _{g})\to \textrm{GL}(n,\mathbb{C})$, there is an energy functional $\textrm{E}_{\rho }: {{\mathcal{T}}}_{g}\to \mathbb{R}$, defined on Teichmüller space by taking the energy of the associated equivariant harmonic map into the symmetric space $\textrm{GL}(n,\mathbb{C})/\textrm{U}(n)$. It follows from a result of Toledo that $\textrm{E}_{\rho }$ is plurisubharmonic, that is, its Levi form is positive semi-definite. We describe the kernel of this Levi form, and relate it to the $\mathbb{C}^{*}$ action on the moduli space of Higgs bundles. We also show that the points in $ {{\mathcal{T}}}_{g}$ where strict plurisubharmonicity fails (i.e., this kernel is non-zero) are critical points of the Hitchin fibration. When $n\geq 2$ and $g\geq 3$, we show that for a generic choice $(S,\rho )$, the map $\textrm{E}_{\rho }$ is strictly plurisubharmonic. We also describe the kernel of the Levi form for $n=1$.
Preserving Law and Order: How Institutions Implementing International Norms on Refugee Protection Can Restrict Asylum Outcomes
Authors: McClean Angela Y 
Published: January 2024

Abstract
The international frameworks on refugee protection, including the 1951 Convention and the 1967 Protocol Relating to the Status of Refugees, are among the strongest norms to govern international mobility. Despite the salience and universality of these international norms, however, asylum outcomes, as indicated by refugee recognition rates (RRRs), vary extensively across state parties. The variation in RRR signals a critical normative gap between the institutionalization and implementation of international norms on refugee protection. In this article, I offer an explanation for this gap by examining the role of domestic institutions responsible for implementing relevant international (and domestic) laws on the ground. Through in-depth interviews, participant observation, and analysis of government, media, and non-governmental organization materials, I investigate the case of South Korea, a wealthy liberal democracy known for its exceptionally low RRR. I argue that South Korea’s low RRR is a result of the preexisting and prevailing ethos of the institutions responsible for refugee status determination, which is deeply rooted in the preservation of law and order and therefore fundamentally conflicts with the human protection principles underlying the Convention.
From Diffusion to Diffuse-ability: A Text-as-Data Approach to Explaining the Global Diffusion of Corporate Sustainability Policy
Authors: Chalmers Adam , Klingler-Vidra Robyn , Malou van den Broek Onna 
Published: January 2024

Abstract
This paper argues that attributes of diffusion objects, in their own right, shape the form and extent of policy diffusion. To date, diffusion scholarship focuses on actor-level attributes (e.g., connections, culture, physical proximity, etc.) to explain what is diffused and how much. Extending existing theory on the impacts of policies’ textual properties on diffusion patterns, we argue that policies that are easier to understand, specific in their applicability, and that do not mandate specific behavior have their text diffused with less adaptation, regardless of the attributes of the authoring organization. We test our argument in the context of the global diffusion of corporate sustainability policy (CSP), analyzing a novel dataset of 1,429 CSPs from 100 countries, 20 international organizations, and 12 regional organizations over a 65-year period. Offering a precise measure of diffusion as the extent to which a source text is copied into an adopter text, we find statistical support for our hypothesis. We contribute to diffusion scholarship by helping to mainstream natural language processing methods and by theorizing how attributes of policy documents affect how much adaptation occurs.
Effects of negative dietary cation–anion difference and calcidiol supplementation in transition diets fed to sows on piglet survival, piglet weight, and sow metabolism
Authors: Weaver Alice Caroline , Braun Thomas Craig , Braun Jeffrey Allan , Golder Helen Marie , Block Elliot , Lean Ian John 
Published: January 2024

Abstract
Diets that provide a negative dietary anion cation difference (DCAD) and supplement with a vitamin D metabolite 25-OH-D3 (calcidiol) may increase calcium availability at parturition, and enhance piglet survival and performance. This factorial study assessed the effects of DCAD, calcidiol (50 µg/kg), and parity (parity 1 or &gt;1) and their interactions. Large White and Landrace sows (n = 328), parity 1 to 8 were randomly allocated in blocks to treatment diets from day 103 of gestation until day 3 postfarrow: 1) negative DCAD without calcidiol (negative DCAD + no CA), n = 84, 2) negative DCAD with calcidiol (negative DCAD + CA) n = 84, 3) positive DCAD without calcidiol (negative DCAD + no CA), n = 81, and 4) positive DCAD with calcidiol (positive DCAD + CA), n = 79. Negative DCAD diets were acidified with an anionic feed (2 kg/t) and magnesium sulfate (2 kg/t). All treatment diets contained cholecalciferol at 1,000 IU/kg. Dry sow diets contained 14.8% crude protein (CP), 5.4% crude fiber (CF), 0.8% Ca, and 83 mEq/kg DCAD. Treatment diets 1 and 2 contained 17.5% CP, 7.3% CF, 0.8% Ca, and −2 mEq/kg DCAD. Treatment diets 3 and 4 contained 17.4% CP, 7.4% CF, 0.8% Ca, and 68 mEq/kg DCAD. Before farrowing, all negative DCAD sows had lower urine pH than all sows fed a positive DCAD (5.66 ± 0.05 and 6.29 ± 0.05, respectively; P &lt; 0.01); urinary pH was acidified for both DCAD treatments indicating metabolic acidification. The percentage of sows with stillborn piglets was not affected by DCAD, calcidiol, or parity alone but sows fed the negative DCAD + CA diet had a 28% reduction in odds of stillbirth compared to the negative DCAD + no CA diet and even lesser odds to the positive DCAD + CA diet. At day 1 after farrowing, blood gas, and mineral and metabolite concentrations were consistent with feeding a negative DCAD diet and that negative DCAD diets influence energy metabolism, as indicated by increased glucose, cholesterol, and osteocalcin concentrations and reduced nonesterified free fatty acids and 3-hydroxybutyrate concentrations. In the subsequent litter, total piglets born and born alive (14.7 ± 0.3 and 13.8 ± 0.3 piglets, respectively; P = 0.029) was greater for positive DCAD diets compared to negative DCAD diets; and there was an interaction between DCAD, calcidiol, and parity (P = 0.002). Feeding a negative DCAD diet influenced stillbirth, subsequent litter size, and metabolic responses at farrowing. More studies are needed to define optimal diets prefarrowing for sows.
3D seismic intelligent prediction of fault-controlled fractured-vuggy reservoirs in carbonate reservoirs based on a deep learning method
Authors: Li Zongjie , Li Haiying , Liu Jun , Deng Guangxiao , Gu Hanming , Yan Zhe 
Published: January 2024

AbstractAccurately predicting the external morphology and internal structure of fractured-vuggy reservoirs is of significant importance for the exploration and development of carbonate oil and gas reservoirs. Conventional seismic prediction methods suffer from serious non-uniqueness and low efficiency, while recent advances in deep learning exhibit strong feature learning capabilities and high generalization. Therefore, this paper proposes an intelligent prediction technique for fault-controlled fracture-vuggy reservoirs based on deep learning methods. The approach involves constructing 3D seismic geological models that conform to the geological characteristics of the study area, simulating seismic wavefield propagation, and combining the interpretation results of fractured-vuggy reservoirs. Training sample datasets are separately established for strike-slip faults, karst caves, and fault-controlled fractured-vuggy reservoir outlines, which are then input into the U-Net model in batches for training. This leads to the creation of a deep learning network model for fault-controlled fractured-vuggy reservoirs. The trained network model is applied to the intelligent identification of fault, karst cave, and fault-controlled fracture-vuggy reservoir outlines using actual seismic data from the Shunbei area. A comparison with traditional methods is conducted, and the experimental results demonstrate that the proposed deep learning approach shows excellent performance in the identification and prediction of fault-controlled fractured-vuggy reservoirs.
Gaskell in China: A History of Translation and Critical Reception
Authors: Zeng Kui 
Published: January 2024

Abstract
This essay traces chronologically Elizabeth Gaskell’s reception in mainland China from 1916 to the present day. It focuses on the ways in which Chinese translations and studies of Gaskell are governed by China’s changing socio-political and cultural concerns. The translation of Gaskell was motivated by cultural reasons in Republican China and by political ones in Maoist China. In the former period, Gaskell’s work was considered useful for the creation of a new, modern Chinese literature, while in the latter period, it was seen as conducive to China’s socialist revolution and education. In the post-Mao era, cultural and commercial considerations have come to dominate Gaskell translation. Serious Chinese Gaskell scholarship emerged as part of the critical effort to reaffirm the historical significance of nineteenth-century European realism in the late 1970s. Since then, Chinese criticism of Gaskell has developed from an initial period dominated by Marxist critical approaches through a formative period marked by feminist approaches to a flourishing period featuring diverse critical approaches. The study of Chinese Gaskell would contribute to the global awareness of foreign Gaskells.
Cystic fibrosis–related diabetes screening at a large pediatric center
Authors: Chokkalla Anil K , Tuley Pamela , Kurtca Miray , Ona Herda , Ruiz Fadel E , Devaraj Sridevi 
Published: January 2024

Abstract

Objective
Cystic Fibrosis Foundation guidelines recommend annual diabetes screening by oral glucose tolerance test (OGTT) in pediatric patients with cystic fibrosis (CF) starting at the age of 10 years. Adherence to these guidelines proves to be challenging, and the nationwide screening rates are still considered suboptimal. The aim of this study was to assess and improve the screening rates at our large pediatric center.

Methods
A 4-year retrospective audit of OGTT completion among pediatric patients with CF of age ≥10 years who are not yet diagnosed with diabetes was conducted. A collaborative working group was formed to identify the barriers to screening and formulate a quality improvement plan, which was monitored and evaluated for a 9-month period.

Results
Diabetes screening rates determined by OGTT completion at our center showed a gradual decline during the COVID-19 pandemic from 2019 to 2022. Following the implementation of the quality improvement plan during the summer of 2023, there was a marked increase in OGTT ordering compliance by providers as well as test completion by patients. Notably, the fractional OGTT completion rate rose from 45% during the preintervention phase (January-April 2023) to 70% during the postintervention phase (May-September 2023).

Conclusion
Diabetes screening in pediatric patients with CF can be effectively improved by refining practices related to patient experience, care coordination, and laboratory testing strategies.
N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA
Authors: Zhou Jiawang , Zhang Haisheng , Zhong Ke , Tao Lijun , Lin Yu , Xie Guoyou , Tan Yonghuang , Wu You , Lu Yunqing , Chen Zhuojia , Li Jiexin , Deng Xin , Peng Qin , Li Zigang , Wang Hongsheng 
Published: January 2024

ABSTRACT
Mitochondria undergo fission and fusion that are critical for cell survival and cancer development, while the regulatory factors for mitochondrial dynamics remain elusive. Herein we found that RNA m6A accelerated mitochondria fusion of colorectal cancer (CRC) cells. Metabolomics analysis and function studies indicated that m6A triggered the generation of glutathione (GSH) via the upregulation of RRM2B—a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential. This in turn resulted in the mitochondria fusion of CRC cells. Mechanistically, m6A methylation of A1240 at 3′UTR of RRM2B increased its mRNA stability via binding with IGF2BP2. Similarly, m6A methylation of A2212 at the coding sequence (CDS) of OPA1—an essential GTPase protein for mitochondrial inner membrane fusion—also increased mRNA stability and triggered mitochondria fusion. Targeting m6A through the methyltransferase inhibitor STM2457 or the dm6ACRISPR system significantly suppressed mitochondria fusion. In vivo and clinical data confirmed the positive roles of the m6A/mitochondrial dynamics in tumor growth and CRC progression. Collectively, m6A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression, which facilitated cancer cell growth and CRC development.