bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza Epidemic Trend Surveillance and Prediction Based on Search Engine Data: Deep Learning Model Study
Authors: Yang Liuyang , Zhang Ting , Han Xuan , Yang Jiao , Sun Yanxia , Ma Libing , Chen Jialong , Li Yanming , Lai Shengjie , Li Wei , Feng Luzhao , Yang Weizhong 
Published: October 2023

Background
Influenza outbreaks pose a significant threat to global public health. Traditional surveillance systems and simple algorithms often struggle to predict influenza outbreaks in an accurate and timely manner. Big data and modern technology have offered new modalities for disease surveillance and prediction. Influenza-like illness can serve as a valuable surveillance tool for emerging respiratory infectious diseases like influenza and COVID-19, especially when reported case data may not fully reflect the actual epidemic curve.

Objective
This study aimed to develop a predictive model for influenza outbreaks by combining Baidu search query data with traditional virological surveillance data. The goal was to improve early detection and preparedness for influenza outbreaks in both northern and southern China, providing evidence for supplementing modern intelligence epidemic surveillance methods.

Methods
We collected virological data from the National Influenza Surveillance Network and Baidu search query data from January 2011 to July 2018, totaling 3,691,865 and 1,563,361 respective samples. Relevant search terms related to influenza were identified and analyzed for their correlation with influenza-positive rates using Pearson correlation analysis. A distributed lag nonlinear model was used to assess the lag correlation of the search terms with influenza activity. Subsequently, a predictive model based on the gated recurrent unit and multiple attention mechanisms was developed to forecast the influenza-positive trend.

Results
This study revealed a high correlation between specific Baidu search terms and influenza-positive rates in both northern and southern China, except for 1 term. The search terms were categorized into 4 groups: essential facts on influenza, influenza symptoms, influenza treatment and medicine, and influenza prevention, all of which showed correlation with the influenza-positive rate. The influenza prevention and influenza symptom groups had a lag correlation of 1.4-3.2 and 5.0-8.0 days, respectively. The Baidu search terms could help predict the influenza-positive rate 14-22 days in advance in southern China but interfered with influenza surveillance in northern China.

Conclusions
Complementing traditional disease surveillance systems with information from web-based data sources can aid in detecting warning signs of influenza outbreaks earlier. However, supplementation of modern surveillance with search engine information should be approached cautiously. This approach provides valuable insights for digital epidemiology and has the potential for broader application in respiratory infectious disease surveillance. Further research should explore the optimization and customization of search terms for different regions and languages to improve the accuracy of influenza prediction models.
Psychological Resilience Factors and Their Association With Weekly Stressor Reactivity During the COVID-19 Outbreak in Europe: Prospective Longitudinal Study
Authors: Bögemann Sophie A , Puhlmann Lara M C , Wackerhagen Carolin , Zerban Matthias , Riepenhausen Antje , Köber Göran , Yuen Kenneth S L , Pooseh Shakoor , Marciniak Marta A , Reppmann Zala , Uściƚko Aleksandra , Weermeijer Jeroen , Lenferink Dionne B , Mituniewicz Julian , Robak Natalia , Donner Nina C , Mestdagh Merijn , Verdonck Stijn , van Dick Rolf , Kleim Birgit , Lieb Klaus , van Leeuwen Judith M C , Kobylińska Dorota , Myin-Germeys Inez , Walter Henrik , Tüscher Oliver , Hermans Erno J , Veer Ilya M , Kalisch Raffael 
Published: October 2023

Background
Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low “stressor reactivity” [SR]), were reported during the first wave of the COVID-19 pandemic in 2020.

Objective
Extending these findings, we here examined prospective relationships and weekly dynamics between the same RFs and SR in a longitudinal sample during the aftermath of the first wave in several European countries.

Methods
Over 5 weeks of app-based assessments, participants reported weekly stressor exposure, mental health problems, RFs, and demographic data in 1 of 6 different languages. As (partly) preregistered, hypotheses were tested cross-sectionally at baseline (N=558), and longitudinally (n=200), using mixed effects models and mediation analyses.

Results
RFs at baseline, including positive appraisal style (PAS), optimism (OPT), general self-efficacy (GSE), perceived good stress recovery (REC), and perceived social support (PSS), were negatively associated with SR scores, not only cross-sectionally (baseline SR scores; all P<.001) but also prospectively (average SR scores across subsequent weeks; positive appraisal (PA), P=.008; OPT, P<.001; GSE, P=.01; REC, P<.001; and PSS, P=.002). In both associations, PAS mediated the effects of PSS on SR (cross-sectionally: 95% CI –0.064 to –0.013; prospectively: 95% CI –0.074 to –0.0008). In the analyses of weekly RF-SR dynamics, the RFs PA of stressors generally and specifically related to the COVID-19 pandemic, and GSE were negatively associated with SR in a contemporaneous fashion (PA, P<.001; PAC,P=.03; and GSE, P<.001), but not in a lagged fashion (PA, P=.36; PAC, P=.52; and GSE, P=.06).

Conclusions
We identified psychological RFs that prospectively predict resilience and cofluctuate with weekly SR within individuals. These prospective results endorse that the previously reported RF-SR associations do not exclusively reflect mood congruency or other temporal bias effects. We further confirm the important role of PA in resilience.
β-Cell miRNA-503-5p Induced by Hypomethylation and Inflammation Promotes Insulin Resistance and β-Cell Decompensation
Authors: Zhou Yuncai , Liu Kerong , Tang Wei , Zhang Yan , Sun Yi , Wu Yangyang , Shi Ying , Yao Zhengjian , Li Yating , Bai Rongjie , Liang Rui , Sun Peng , Chang Xiaoai , Wang Shusen , Zhu Yunxia , Han Xiao 
Published: October 2023

Chronic inflammation promotes pancreatic β-cell decompensation to insulin resistance because of local accumulation of supraphysiologic interleukin 1β (IL-1β) levels. However, the underlying molecular mechanisms remain elusive. We show that miR-503-5p is exclusively upregulated in islets from humans with type 2 diabetes and diabetic rodents because of its promoter hypomethylation and increased local IL-1β levels. β-Cell–specific miR-503 transgenic mice display mild or severe diabetes in a time- and expression-dependent manner. By contrast, deletion of the miR-503 cluster protects mice from high-fat diet–induced insulin resistance and glucose intolerance. Mechanistically, miR-503-5p represses c-Jun N-terminal kinase–interacting protein 2 (JIP2) translation to activate mitogen-activated protein kinase signaling cascades, thus inhibiting glucose-stimulated insulin secretion (GSIS) and compensatory β-cell proliferation. In addition, β-cell miR-503-5p is packaged in nanovesicles to dampen insulin signaling transduction in liver and adipose tissues by targeting insulin receptors. Notably, specifically blocking the miR-503 cluster in β-cells effectively remits aging-associated diabetes through recovery of GSIS capacity and insulin sensitivity. Our findings demonstrate that β-cell miR-503-5p is required for the development of insulin resistance and β-cell decompensation, providing a potential therapeutic target against diabetes.

Article Highlights
Promoter hypomethylation during natural aging permits miR-503-5p overexpression in islets under inflammation conditions, conserving from rodents to humans. Impaired β-cells release nanovesicular miR-503-5p to accumulate in liver and adipose tissue, leading to their insulin resistance via the miR-503-5p/insulin receptor/phosphorylated AKT axis. Accumulated miR-503-5p in β-cells impairs glucose-stimulated insulin secretion via the JIP2-coordinated mitogen-activated protein kinase signaling cascades. Specific blockage of β-cell miR-503-5p improves β-cell function and glucose tolerance in aging mice.
Tid för abduktion: Erfarenhetens bärkraft i forskning och utbildning för framtiden
Authors: Balldin Jutta 
Published: October 2023

Syftet med artikeln är att med stöd i Charles S. Peirces kontinuerliga logik argumentera för en pedagogik som avser att verifiera och i större utsträckning göra bruk av erfarenhet i kunskapsbildningsprocesser. Därutöver vill jag med Peirces hjälp slå ett slag för abduktion som en metod vilken särskilt uppmärksammar skillnader mellan kunskaper och kvaliteter och verkar för en mer pluralistisk och samtidigt gemensam kunskapsbildning. En abduktiv tidsattityd motverkar idén om absolut kunskap och påminner om vår tendens att ignorera det vi av erfarenhet vet och eventuellt också tvekar om. Med Peirces logik är tvekan inför kunskap men tillit till det vi vet istället grunden för ny kunskapsbildning och i en generell mening också världens fortgång. För att ytterligare belysa abduktionens pedagogiska förtjänster beskriver jag hur ett kombinerat forsknings- och utbildningsprojekt i högre utbildning växer fram och tar form i enlighet med metodens tidsenligt successiv a slutledningsprocess. Det pågående projektets uppkomst och process följer abduktionens tre överlappande faser från dåtidens erfarenhet, över nuets reaktion, mot framtidens obestämda men möjliga handlingar.
ENGLISH ABSTRACT
Time för abduction: The carrying capacity of experience in research and education
The article aims to reason with the continuous philosophy of Charles S. Peirce (1839–1914) and argue about a pedagogy for strengthening our ability to diversify and bring forth our experience in knowledge production. The carrying capacity of experience as a basis for reasonable abductions and change is the main argument of the article. Besides this the ambition is to highlight the capacity of abduction as a method to process diverse knowledge practices and make use of pluralistic thus common experiences to produce fair ideas for the future. The temporal attitude of the abductive researcher counteracts the idea of absolute knowledge and reminds us of our tendency to ignore what we actually know, not the least doubt. Thus, the abductive attitude approves of doubt as a wake-up call and starting point for learning, and the acknowledgement of this is by Peirce’s general logic also consistent with a trust in a continuous human and worldly becoming. To further illuminate the educational points of abduction, an ongoing project in higher education is described as a concrete example of abductive, thus experience-based, successive, and common learning. The continuous research/education project unfolds and finds its direction through the triadic abductive process of inference; notifying and acknowledging qualities of past experience, critically comparing qualities to general ideas, and guessing upon new relations or hypothesis about fair future conduct.
Blast Disease Behavior in Some Boro Rice Varieties of Bangladesh and Development of Induced Resistance System Against Blast Disease through Selected Novel Chemicals
Authors: Akter Shammy , Chowdhury Nisha Hosna Ara , Ferdous Raihan , Sultana Rifat Ara , Hoque Sanzida , Hossain Md. Belal 
Published: October 2023

Chronologically two experiments have been conducted during the period from October 2018 to May 2019 and July 2019 to June 2020 at Sher-e-Bangla Agricultural University, Bangladesh for the identification of one of the best rice varieties and chemicals against blast disease. In a field experiment, eight boro rice varieties were evaluated (five inbreed varieties, two high-yielding varieties, and one wild variety) to observe varietal performances against blast disease. A pot experiment was also performed to study the resistance behavior of the tested varieties in an in-vitro condition by applying silica powder, K2SiO3, salicylic acid, cattle urine (both normal and pregnant cows), and PPN. Field study revealed that the wild variety was highly resistant (incidence and severity 0%) whereas BRRI dhan58 was susceptible (incidence 21.48% and severity 60.48%). Wild variety was also characterized by the highest tiller number (20.73), panicle length (24.90 cm), fresh grain weight (62.30 g), and dry grain weight (51.70 g). The highest number of panicles was recorded in BRRI dhan28 (18.40) which was statistically like the wild variety (17.50). Though wild variety performed best in another parameter it gave the lowest amount of yield (4.77 kg/plot). In morphological studies of pathogen, pyriform-shaped conidia were found in a sympodial fashion on conidiophores whose size varied from 22.13 to 28.47 μm × 9.13 to 11.72 μm (average 25.30×10.43 μm). The second experiment revealed that all selected novel chemicals showed some extent of resistance but the cattle urine, PPN, and K2SiO3 showed a promising effect. Koch’s postulate test for the experiment confirmed the causal organism of blast disease is Magnaporthe oryzaein artificially inoculated plants.
Docking Pose Measurement Method for Large Components Based on Draw-Wire Displacement Sensors
Authors: Sun Zheng-yang , Wang Hong-xi , Tian Hui-hui , Liu Bing 
Published: October 2023

Abstract
A method for measuring the docking pose of large components based on the draw-wire displacement sensor is proposed. In this method, coordinate systems and measurement points are established on the docking surfaces of fixed and moving components. The draw-wire displacement sensor is used to measure the distances between these measurement points. A mathematical model based on the distances between the measurement points is established, and the three-sphere rendezvous positioning principle is optimized to obtain the spatial positions of the measurement points. Consequently, the pose deviations of the fixed and moving components in all six degrees of freedom (6DOF) are determined. A simulation analysis of the measurement uncertainty of the obtained pose deviations is performed, resulting in a composite standard uncertainty obtained from the measurement standard uncertainties of different sensors. The simulation results show that the composite standard uncertainty is most affected in the x-axis translation direction and least affected in the x-axis rotation direction. With this method, only the distances between the measurement points need to be measured to determine the corresponding pose relationships. The cost of the equipment is low, and it is not easily affected by external factors such as the environment.
Interstitial lung disease with genetic susceptibility: case report
Authors: Ana Aleksandra , Trușculescu Adriana Ana 
Published: October 2023

AbstractIntroductionInterstitial lung disease (ILD) includes more than 200 progressive conditions classified based on common clinical, imaging or pathophysiological factors.Case presentationA 37-year-old male, former smoker, with unknown exposure and a family history of incompletely identified ILD, underwent functional and imaging investigations that raise the suspicion of an ILD with a pattern of non-specific interstitial pneumonia (NSIP). High-resolution computer tomography (HRCT) imaging detects the progression of lesions. The severely altered functional status does not allow a lung biopsy to be performed to elucidate the aetiology and establish the optimal therapeutic approach. Bronchoscopy with bronchial aspirate sampling and bronchoalveolar lavage does not suggest a specific ILD aetiology. A diagnosis of diffuse fibrosing and progressive ILD – an unclassifiable phenotype – was established, and after a multidisciplinary discussion, antifibrotic treatment was initiated. A genetic test was performed for a possible familial ILD with a genetic component. The test identified the presence of an autosomal recessive combined immunodeficiency due to NF-κB inducing kinase (NIK) deficiency associated with the MAP3K14 gene leading to the suspicion of a familial ILD.DiscussionGenetic testing is essential for diagnosis of ILD, especially in young patients with a family history. Antifibrotics are the only available option for such cases; if immunosuppressive therapy should be initiated still remains a question. Is a lung transplant a realistic solution in such cases?ConclusionsFamilial aggregation and genetic changes should be sought for in diffuse ILD diagnosis.
Factors Affecting Behavioral Intention of Tourists to Travel into Local Destinations in Rayong Province, Thailand
Authors: Vuthisopon Sujira , Sampaio Fernando , Boonnual Chutimant 
Published: October 2023

Purpose: This study aims to explore the factors affecting behavioral intention of tourists to travel into local destinations in Rayong Province, Thailand and to examine destination personality, tourist connection with destination, and tourists’ behavioral intention to visit the local tourist attractions in Rayong province. In addition, the study explored on the influences from the self-brand connection as the transmission factor from destination personality to the behavioral intention for visitation.

Theoretical framework: Destination Personality consisting of (1) conviviality, (2) sincerity, (3) excitement influence Self-brand connections which lead to Behavioral intention of revisiting intention and recommendation intention.

Methodology: This was quantitative research that used questionnaire to collect data from 385 tourists. Data were analyzed by Structural Equation Model (SEM)

Results and conclusion: The destination personality and self-brand connection had the influences on the behavioral intention to visit the destination confirmed by the empirical results stating that the brand connection are the transmission factor of destination personality toward the behavioral intention to travel.

Research Implications: This study benefits the tourism industry in Rayong province to realize the behavioral intention of tourists to travel into local destinations in Rayong Province so they can improve their destination personality and brand connection in order to gain revisiting of tourists.

Originality value: This study presents the new knowledge of destination personality and tourist attraction brand connection that they are related and have direct influences on tourist intentions to revisit the place.
Peasants, Good Living and Agroecology for Rural Development
Authors: Souza Alessandra Barbosa , Dos Santos Núbia Dias , Soares Maria José Nascimento 
Published: October 2023

Objective: To understand the possibility of rural development that interrelates the principles of good living and the practice of agroecology to rural development.

Theoretical reference: The Good Living and its perspective of building a society that comprises a balanced and respectful coexistence with nature; agroecology as an alternative for survival in the rural environment and rural development that brings with it many demands and the need to (re)know the plurality of rural peoples.

Methodology: Exploratory bibliographic research with content analysis that aims to understand and explain how the peasant way of life interrelates the theory of the Good Living with agroecological practices for rural development.

Results and conclusion: We highlight the broadening of the debate on the subject addressed, in order to collaborate scientifically with the studies about the peasant and his life in the countryside. What is expected of rural development is that it promotes improvement in the lives of peasants, thus enabling them to remain in the countryside, with quality of life.

Implication of research: By pursuing existing integration in the principles of living well with agroecology, research offers an innovative approach to sustainable rural development including the promotion of environmental conservation and the well-being of peasant communities.

Originality: Lies in the interdisciplinary and innovative approach that seeks to integrate the principles of Good Living, with the practice of agroecology. This approach contributes to an evolving field of study, providing new perspectives in the search for solutions to the challenges faced by rural communities and contemporary agriculture.
Pengaruh Nilai Ketahanan Tarik Terhadap Daya Regang Dalam Pembuatan Kertas Dari Bahan Baku Kulit Singkong dan Daun Nanas
Authors: Ningsih Mulia , Sirait Ratni , Jumiati Ety 
Published: October 2023

Â Kertas dihasilkan dari bahan setengah jadi (pulp) yang mengandung selulosa. Bahan baku yang digunakan kulit singkong dan daun nanas, karena mengandung selulosa yang tinggi diatas 40%. Tujuan penelitian untuk mengetahui karakteristik kertas dan variasi komposisi terbaik kertas dari kulit singkong dan daun nanas. Metode pembuatan pulp menggunakan proses soda. Variasi berat sampel A (80:20%), B (60:40%), C (40:60%) dan D (20:80%). Kulit singkong dan daun nanas dipanaskan menggunakan hot plate dengan penambahan NaOH 1,5% dengan suhu 100ËšC. Proses pemutihan menggunakan larutan H2O2 10%. Hasil karakterisasi kertas pada sampel menunjukkan bahwa nilai uji ketahanan tarik sampel A bernilai 0,2567 MPa, B bernilai 0,4854 MPa, C bernilai 1,3127 Mpa dan D bernilai 1,4322 MPa dan daya regang sampel A sebesar 0,70%, B sebesar 0,86%, C sebesar 1,69%, dan D sebesar 2,05%. Berdasarkan data menunjukkan bahwa sampel D yang terbaik dan telah memenuhi kertas cetak C SNI 14-0937-2005 dalam pembuatan kertas.Â Â Â Â Â Â Â Â Â
A FINANCEIRIZAÇÃO DOS PAÍSES DEPENDENTES E O PAPEL DO DIREITO.
Authors: Esteves Juliana Teixeira 
Published: October 2023

A sociedade atual é envolvida em negociações globais e sofremos todas as consequências disso. Partindo da premissa de que a globalização é uma forma de maximização da extração da mais valia e, associado ao crescimento do modo financeiro de administração, produz efeitos inexoráveis à liberdade de um país como o nosso, o artigo investiga formas que o sistema financeiro está se utilizando para maximizar o seu poder sobre a autonomia de alguns países de se autogovernarem. As pesquisas realizadas comprovam a interferência com o respaldo jurídico, legislativo e judicial, afetando direitos sociais das comunidades civis, protegidas ou não por legislação específica.
Studi Kasus Penerapan Teknik Handgrip Exercise Terhadap Penurunan Tekanan Darah
Authors: Marsela Agstri Dwi , Samiasih Amin 
Published: October 2023

Hipertensi merupakan keadaan dimana tekanan darah meningkat melebihi batas normal dengan tekanan sistolik140mmHg dan tekanan darah diastolik 90 mmHg. Salah satu gejala yang dapat timbul dalam peningkatan tekanan darah berupa nyeri kepala. Aktivitas fisik latihan pembebanan seperti isometric handgrip dapat berpengaruh terhadap tekanan darah. Studi ini bertujuan menerapkan teknik handgrip exercise untuk penurunan tekanan darah pada asuhan keperawatan pasien hipertensi. Studi kasus ini mengguakan desain deskriptif dengan pendekatan asuhan keperawatan. Subjek studi kasus adalah pasien hipertensi sejumlah 2 paisen yang didapatkan secara incidental. Intervensi yang diberikan berupa evidence based practice teknik handgrip exercise selama ±15 menit. Alat ukur dalam penelitian ini menggunakan sphygmomanometer, yang digunakan untuk mengukur tekanan darah sebelum dan sesudah penerapan teknik handgrip exercise. Studi kasus dalam penerapan ini dilakukan selama 5 hari berturut-turut pada tanggal 17 Mei 2021 dan 12 July 2021 di kota Metro, provinsi Lampung. Pemberian teknik handgrip exercise selama 5 hari pada pasien menunjukan terdapat penurunan tekanan darah dengan rata-rata penurunan tekanan darah sistolik pada kedua pasien yaitu 7,5 mmHg dan rata-rata penurunan tekanan darah diastolik pada kedua pasien adalah 10 mmHg. Penerapan teknik handgrip exercise yang penulis lakukan, memberikan pengaruh terhadap penurunan tekanan darah sistolik dan diastolic pada pasien hipertensi. Teknik handgrip exercise dapat digunakan sebagai salah satu penatalaksanaan non-farmakologi untuk pasien hipertensi.