bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical stress distribution over the palate by different pacifiers assessed by finite element analysis and clinical data
Authors: Freitas Camila Nobre de , Castelo Paula Midori , Noritomi Pedro Yoshito , Scudine Kelly Guedes de Oliveira , Rontani Regina Maria Puppin , Miziara Thanus , Machado Leonardo Mendes Ribeiro 
Published: November 2023

AbstractThe mechanical behavior of each type of pacifier on rigid structures and their various impacts on orofacial growth have yet to be discovered. The study aimed to evaluate the stress distribution over a child's palate by three types of pacifiers using finite element analysis and clinical and laboratory data. Modulus of elasticity was obtained from 30 specimens comprising 10 of each conventional (A), orthodontic (B), and breast‐shaped (C) pacifiers. Tongue strength was assessed in eight 3‐year‐old children (kPa). A hemi‐maxilla model was obtained from 2‐ to 3‐year‐old skull tomography, and the images of pacifiers A, B, and C were captured using 3D scanning. The Hypermesh® program generated a mesh of 6‐node tetrahedral elements for applying forces in the X, Y, and Z directions to enable a nonlinear analysis. Pacifier B exhibited the highest values for distributed stress on the palate, followed by pacifier A. Pacifier B stimulated the maxilla forward and sideways. In contrast, pacifier A promoted a forward and upward load, favoring a more atresic palate. Pacifiers A and B tended to rotate in the sagittal plane, generating tensions in the anterior incisors and favoring the open bite. Pacifier C exhibited lateral expansion by stress induction over the mid‐palatal suture with less influence on incisor inclination. Pacifiers showed different detrimental stress distributions on the palate. This information can be helpful for improving recommendations given to parents.
Women as bodies. The role of ambivalent sexism and sexual objectification on non‐consensual sharing of sexting images
Authors: Agueli Barbara , Esposito Ciro , Arcidiacono Caterina , Di Napoli Immacolata 
Published: November 2023

AbstractDiscriminatory attitudes towards women are still widespread and have also pervaded the digital world. They are often connected with the propensity to view and treat women as sexual objects, which sometimes leads to negative and harmful behaviours, such as the sharing of intimate images without the partner's consent. The present study aims at investigating the non‐consensual sharing of intimate images in relation to benevolent and hostile sexism, direct and mediated by female sexual objectification. The sample was recruited through the snowball sampling technique and was made up of 2,305 young Italian adults aged between 18 and 35. Analysis was carried out using structural equation modelling and the multigroup mediation model, allowing us to detect any gender differences. For both, males and females, results show that benevolent sexism has neither a direct nor indirect correlation with non‐consensual sharing of sexts. Instead, hostile sexism has an indirect relation with non‐consensual sharing mediated by the sexual objectification of the woman's body. Results do not show differences between male and female groups and highlight the need to focus on the socio‐cultural context that enables the non‐consensual sharing of intimate images, which is a variety of cyberviolence against women. Practical implications of the results will be extensively discussed. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
HPLC/ESI‐MS Characterization of Phenolic Compounds from Cnicus benedictus L. Roots: A Study of Antioxidant, Antibacterial, Anti‐Inflammatory, and Anti‐Alzheimer's Activity
Authors: Rezig Khalid , Benkaci‐Ali Farid , Fauconnier Marie‐Laure , Laurent Sophie , Umar Haruna Isiyaku , Alex Omoboyowa Damilola , Tata Samira 
Published: November 2023

AbstractThe phenolic composition of Cnicus benedictus roots from four Algerian regions was investigated. Extractions were performed in both hydro‐methanolic (30 : 70, v/v) and hydro‐ethanolic (30 : 70, v/v) solvents. Their efficiency was determined in terms of the qualitative and quantitative composition in phenolic compounds by HPLC‐LC/MS of the different extracts isolated from C. Benedictus roots. Cnicus benedictus roots extract have been characterized by high content of phenolic compounds, where the trans chalcone, 2,3‐dihydro flavone, 3‐hydroxy flavone and cinnamic acid constitute the major components, in addition to fourteen minor acidic compounds and flavonoids as rutin. The hydro‐methanolic extract was the richest in phenolic compounds yield from C benedictus. On the other hand, hydro methanolic (30 : 70, v/v) and hydro ethanolic (30 : 70, v/v) extracts exhibited a high anti‐inflammatory activity by in vitro 5‐lipoxygenase inhibitory activity (IC50: 6.05±94.16 μg/mL) as well as by in silico docking according two methods. Likewise, anti‐Alzheimer activity of extracts was confirmed by this last technique taking into account the major compounds identified. Antibacterial tests revealed interesting results compared to amoxicillin for the different regions studied with a high content in trans chalcone and 3‐hydroxy Flavone.
Functional and Extracellular Production and Antitumor Activity of Mouse Alpha Klotho in Model Microalga Chlamydomonas reinhardtii
Authors: Çakmak Ramazan , Uzuner Ugur 
Published: November 2023

AbstractKlotho is a human protein with versatile functions associated with longevity and well‐being. α‐Klotho (α‐KL) deficiency in the circulatory system is associated with reduced life expectancy with numerous disorders such as chronic kidney disease, atherosclerosis, infertility, skin atrophy, emphysema, and osteoporosis. The antagonistic effects of Klotho protein against intractable cancers have also been well documented over the past two decades. In addition, recent findings have also illuminated the importance of soluble Klotho during cognitive development, oxidative stress, cellular apoptosis, and neurodegenerative disorders. The low‐cost and sustainable production of alpha Klotho protein is extremely important for its widespread use against different diseases. Here, we report heterologous, functional, and extracellular production of mouse α‐KL (mα‐KL) protein in model microalga Chlamydomonas reinhardtii. The secretion of mα‐KL into the extracellular environment facilitated downstream processes and warranted low‐cost purification in high‐titer. Furthermore, the anticarcinogenic efficiency of recombinant mα‐KL was examined and validated on Rattus norvegicus AR42J pancreas tumors. Microalgae‐based photosynthetic, low‐cost, and scalable production of mα‐KL could be used to develop a variety of cosmetics, pharmaceuticals, and wellness products, all aimed at serving health and well‐being.
Optical Coherence Tomography Predictors of SIde Branch REstenosis after unprotected Left Main bifurcation angioplasty using double kissing crush technique (OP‐SIBRE LM Study)
Authors: Gupta Ankush , Shrivastava Abhinav , Chhikara Sanya , Mamas Mamas A. , Vijayvergiya Rajesh , Swamy Ajay , Mahesh Nalin K. , Singh Navreet , Bajaj Nitin , Singh Balwinder , Meena Daulat Singh , Singh Chandraket 
Published: November 2023

AbstractBackgroundAmong the two stent strategies, contemporary evidence favors double kissing crush technique (DKC) for complex unprotected distal left main bifurcation (UdLMB) lesions. However one of the major challenges to these lesions is side branch (SB) restenosis.AimsOur aim was to identify optical coherence tomographic (OCT) characteristics that may predict SB restenosis (SBR) after UdLMB angioplasty using DKC technique.MethodsThis was a single‐center, retrospective study that included 60 patients with complex UdLMB disease, who underwent OCT‐guided angioplasty using DKC technique. Angiographic follow‐up was performed in all patients at 1 year to identify patients with SBR. Patients with SBR group were compared with patients without SBR (NSBR group) for OCT parameters during index procedure.ResultsTwelve (20%) patients developed SBR at 1‐year follow‐up. The SBR group had longer SB lesion (18.8 ± 3.2 vs. 15.3 ± 3.7 mm, p = 0.004) and neo‐metallic carinal length (2.1 vs. 0.1 mm, p < 0.001) when compared to the NSBR group. Longer neo‐metallic carinal length was associated with the absence of the dumbbell sign, presence of hanging stent struts across the SB ostium on OCT of final MB pullback. On multivariate regression analysis, SB distal reference diameter (DRD) and SB stent expansion were identified as independent predictors of SBR with SB‐DRD of ≤2.8 mm (area under curve—0.73, sensitivity—83.3%, and specificity—62.5%) and SB stent expansion of ≤89% (area under curve—0.88, sensitivity—83.3%, and specificity‐ 81.2%) as the best cut off values to predict SBR.ConclusionsSB DRD and SB stent expansion are the OCT predictors of future SBR after UdLMB angioplasty using DKC technique.
Computed tomography derived anatomical predictors of vascular access complications following transfemoral transcatheter aortic valve implantation: A systematic review
Authors: Androshchuk Vitaliy , Chehab Omar , Prendergast Bernard , Rajani Ronak , Patterson Tiffany , Redwood Simon 
Published: November 2023

AbstractBackgroundVascular complications after percutaneous transfemoral transcatheter aortic valve implantation (TAVI) are associated with adverse clinical outcomes and remain a significant challenge.AimsThe purpose of this review is to synthesize the existing evidence regarding the iliofemoral artery features predictive of vascular complications after TAVI on pre‐procedural contrast‐enhanced multidetector computed tomography (MDCT).MethodsA systematic search was performed in Embase and Medline (Pubmed) databases. Studies of patients undergoing transfemoral TAVI with MDCT were included. Studies with only valve‐in‐valve TAVI, planned surgical intervention and those using fluoroscopic assessment were excluded. Data on study cohort, procedural characteristics and significant predictors of vascular complications were extracted.ResultsWe identified 23 original studies involving 8697 patients who underwent TAVI between 2006 and 2020. Of all patients, 8514 (97.9%) underwent percutaneous transfemoral‐TAVI, of which 8068 (94.8%) had contrast‐enhanced MDCT. The incidence of major vascular complications was 6.7 ± 4.1% and minor vascular complications 26.1 ± 7.8%. Significant independent predictors of major and minor complications related to vessel dimensions were common femoral artery depth (>54 mm), sheath‐to‐iliofemoral artery diameter ratio (>0.91–1.19), sheath‐to‐femoral artery diameter ratio (>1.03–1.45) and sheath‐to‐femoral artery area ratio (>1.35). Substantial iliofemoral vessel tortuosity predicted 2–5‐fold higher vascular risk. Significant iliofemoral calcification predicted 2–5‐fold higher risk. The iliac morphology score was the only hybrid scoring system with predictive value.ConclusionsIndependent iliofemoral predictors of access‐site complications in TAVI were related to vessel size, depth, calcification and tortuosity. These should be considered when planning transfemoral TAVI and in the design of future risk prediction models.
A premature newborn born to an adolescent girl with acute Ebola virus disease and malaria survives in a resource‐limited setting in an Ebola treatment unit in DR Congo: “A case report”
Authors: Imani‐Musimwa Prince , Grant Emilie , Feza‐Malira Micheline , Mbala‐Kingebeni Placide , Buhoro‐Baabo Gisèle , Zawadi‐Endanda Espérence , Fraterne‐Muhayangabo Rigo , Claris‐Mwatsi Inès , Tsongo‐Kibendelwa Zacharie , Nyakio‐Ngeleza Olivier , Juakali‐Kyolov Sihali , Wembonyama‐Okitosho Stanis , Sengey‐Mushengezi‐Amani Dieudonné , Mukadi‐Bamuleka Daniel , Ververs Mija 
Published: November 2023

Key Clinical MessageIn the acute phase of Ebola virus disease (EVD) premature neonatal survival is extremely rare. High mortality is related to prematurity, neonatal complications of Ebola, and precarious conditions of neonatal care in underresourced ETUs. This is a case of preterm neonatal survival in the setting of acute maternal EVD infection.AbstractThis case describes rare preterm newborn survival in the setting of an Ebola treatment unit in Eastern DRC. The neonate was born vaginally to an acutely ill 17‐year‐old mother who was vaccinated against Ebola virus after being identified as a contact of her father, who was a confirmed case and who did not survive his infection. This woman was admitted to an Ebola treatment unit at 32 weeks of gestation and given monoclonal antibody treatment. She gave birth vaginally, succumbing to postpartum hemorrhage 14 h after delivery. This child survived despite compounding vulnerabilities of preterm birth and maternal Ebola infection. Despite a negative test for EVD, the neonate was given a single dose of monoclonal antibody therapy in the first days of life. We believe maternal vaccination and neonatal monoclonal antibody treatment contributed to the child's survival. The circumstances surrounding neonatal survival in this extremely resource‐limited context must be analyzed and disseminated in order to increase rates of neonatal and maternal survival in future outbreaks. Maternal and neonatal health are critical aspects of outbreak response that have been understudied and underreported leaving clinicians severely underresourced to provide life‐saving care in outbreak settings. Pregnancy and childbirth do not stop in times of disease outbreak, adequate equipment and trained staff required for quality neonatal care must be considered in future outbreak responses.
Stabilization of Luminescent Mononuclear Three‐Coordinate CuI Complexes by Two Distinct Cavity‐Shaped Diphosphanes Obtained from a Single α‐Cyclodextrin Precursor
Authors: Phan Tuan‐Anh , Jouffroy Matthieu , Matt Dominique , Armaroli Nicola , Moncada Alejandra Saavedra , Bandini Elisa , Delavaux‐Nicot Béatrice , Nierengarten Jean‐François , Armspach Dominique 
Published: November 2023

AbstractSlightly different reaction conditions afforded two distinct cavity‐shaped cis‐chelating diphosphanes from the same starting materials, namely diphenyl(2‐phosphanylphenyl)phosphane and an α–cyclodextrin‐derived dimesylate. Thanks to their metal‐confining properties, the two diphosphanes form only mononuclear [CuX(PP)] complexes (X=Cl, Br, or I) with the tricoordinated metal ion located just above the center of the cavity. The two series of CuI complexes display markedly different luminescence properties that are both influenced by the electronic properties of the ligand and the unique steric environment provided by the cyclodextrin (CD) cavity. The excited state lifetimes of all complexes are significantly longer than those of the cavity‐free analogues suggesting peculiar electronic effects that affect radiative deactivation constants. The overall picture stemming from absorption and emission data suggests close‐lying charge‐transfer (MLCT, XLCT) and triplet ligand‐centered (LC) excited states.
The association between neighborhood‐level income and cancer stage at diagnosis and survival in Alberta
Authors: Ruan Yibing , Heer Emily , Warkentin Matthew T. , Jarada Tamer N. , O’Sullivan Dylan E. , Hao Desiree , Ezeife Doreen , Cheung Winson , Brenner Darren R. 
Published: November 2023

AbstractBackgroundSocioeconomic status (SES) is associated with a range of health outcomes, including cancer diagnosis and survival. However, the evidence for this association is inconsistent between countries with and without single‐payer health care systems. In this study, the relationships between neighborhood‐level income, cancer stage at diagnosis, and cancer‐specific mortality in Alberta, Canada, were evaluated.MethodsThe Alberta Cancer Registry was used to identify all primary cancer diagnoses between 2010 and 2020. Average neighborhood income was determined by linking the Canadian census to postal codes and was categorized into quintiles on the basis of income distribution in Alberta. Multivariable multinomial logistic regression was used to model the association between income quintile and stage at diagnosis, and the Fine–Gray proportional subdistribution hazards model was used to estimate the association between SES and cancer‐specific mortality.ResultsOut of the 143,818 patients with cancer included in the study, those in lower income quintiles were significantly more likely to be diagnosed at stage III (odds ratio [OR], 1.07; 95% CI [confidence interval], 1.06–1.09) or IV (OR, 1.12; 95% CI, 1.11–1.14) after adjusting for age and sex. Lower income quintiles also had significantly worse cancer‐specific survival for breast, colorectal, liver, lung, non‐Hodgkin lymphoma, oral cavity, pancreas, and prostate cancers.ConclusionsDisparities were observed in cancer outcomes across neighborhood‐level income groups in Alberta, which demonstrates that health inequities by SES exist in countries with single‐payer health care systems. Further research is needed to better understand the underlying causes and to develop strategies to mitigate these disparities.
The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye
Authors: Sala Lorenzo , Prud'homme Christophe , Guidoboni Giovanna , Szopos Marcela , Harris Alon 
Published: November 2023

AbstractWe present our continuous efforts from a modeling and numerical viewpoint to develop a powerful and flexible mathematical and computational framework called Ocular Mathematical Virtual Simulator (OMVS). The OMVS aims to solve problems arising in biomechanics and hemodynamics within the human eye. We discuss our contribution towards improving the reliability and reproducibility of computational studies by performing a thorough validation of the numerical predictions against experimental data. The OMVS proved capable of simulating complex multiphysics and multiscale scenarios motivated by the study of glaucoma. Furthermore, its modular design allows the continuous integration of new models and methods as the research moves forward, and supports the utilization of the OMVS as a promising non‐invasive clinical investigation tool for personalized research in ophthalmology.
Bioequivalence Study of Capsules versus Film Tablets Containing Rivaroxaban in Healthy Caucasian Subjects under Fasting and Fed Conditions
Authors: Sözer Gökçe , Inal Ahmet , Sezer Zafer , Martin Wolfgang , Ottmann Ewald , Reinsch Martin , Koru Selma Alime 
Published: November 2023

AbstractThe bioequivalence (BE) of orally administered capsules versus film tablets containing 20 and 10 mg of rivaroxaban was assessed in 2 single‐dose, open‐label, randomized 2‐way crossover trials with a washout period of at least 1 week. The study for the 10 mg strength was conducted under fasting conditions (n = 68) and the study for the 20 mg strength under fed conditions (n = 52). Blood samples were collected over a 36‐hour period and concentrations were assayed using a liquid chromatography tandem mass spectrometry method. Pharmacokinetic (PK) evaluation was performed with the program Phoenix WinNonlin, for non‐compartmental assessment of data.After administration of 10 mg rivaroxaban under fasting conditions, mean Area Under the time ‐ concentration Curve until the last blood sampling point (AUCt), Area Under the time ‐ concentration Curve until infinity (AUC∞), and maximum plasma concentration (Cmax) were comparable (972 ng/mL*h, 1048 ng/mL*h, and 111 ng/mL, respectively, for the test and 1013 ng/mL*h, 1070 ng/mL*h and 130 ng/mL, respectively, for the reference formulation). Mean AUCt, AUC∞, and Cmax were also comparable under fed conditions after administration of 20 mg rivaroxaban (2145 ng/mL*h, 2198 ng/mL*h and 275 ng/mL, respectively, for the test and 1856 ng/mL*h, 1916 ng/mL*h and 240 ng/mL, respectively, for the reference formulation). The 90% confidence intervals for all PK parameters were within the acceptance range of 80%‐125%, suggesting BE between the generic product and the innovator product in healthy Caucasian male subjects. A clinically relevant difference in the tolerability and safety of the treatments was not detected. Study results indicated that the capsule formulations were bioequivalent with the film tablet formulations.
Direct Electrochemical Synthesis of Metal‐Organic Frameworks: Cu3(BTC)2 and Cu(TCPP) on Copper Thin films and Copper‐Based Microstructures
Authors: Araújo‐Cordero Ana María , Caddeo Francesco , Mahmoudi Behzad , Bron Michael , Wouter Maijenburg A. 
Published: November 2023

AbstractCu thin films and Cu2O microstructures were partially converted to the Metal‐Organic Frameworks (MOFs) Cu3(BTC)2 or Cu(TCPP) using an electrochemical process with a higher control and at milder conditions compared to the traditional solvothermal MOF synthesis. Initially, either a Cu thin film was sputtered, or different kinds of Cu or Cu2O microstructures were electrochemically deposited onto a conductive ITO glass substrate. Then, these Cu thin films or Cu‐based microstructures were subsequently coated with a thin layer of either Cu3(BTC)2 or Cu(TCPP) by controlled anodic dissolution of the Cu‐based substrate at room temperature and in the presence of the desired organic linker molecules: 1,3,5‐benzenetricarboxylic acid (BTC) or photoactive 4,4′,4′′,4′′′‐(Porphine‐5,10,15,20‐tetrayl) tetrakis(benzoic acid) (TCPP) in the electrolyte. An increase in size of the Cu micro cubes with exposed planes [100] of 38,7 % for the Cu2O@Cu3(BTC)2 and a 68,9 % increase for the Cu2O@Cu(TCPP) was roughly estimated. Finally, XRD, Raman spectroscopy and UV–vis absorption spectroscopy were used to characterize the initial Cu films or Cu‐based microstructures, and the obtained core‐shell Cu2O@Cu(BTC) and Cu2O@Cu(TCPP) microstructures.
Quantification of quercetin from red onion (Allium cepa L.) powder via high‐performance liquid chromatography‐ultraviolet (HPLC‐UV) and its effect on hyperuricemia in male healthy Wistar albino rats
Authors: Umer Muhammad , Nisa Mahr Un , Ahmad Nazir , Rahim Muhammad Abdul , Kasankala Ladislaus Manaku 
Published: November 2023

AbstractOnions (Allium cepa L.) contain various flavonols, including quercetin, kaempferol, anthocyanin, luteolin, and myricetin. Quercetin in onions is considered the primary bioactive component. To assess the impact of quercetin on hyperuricemia in healthy Wistar albino rats, this study used high‐performance liquid chromatography with ultraviolet (HPLC‐UV) to identify and measure quercetin in onion powder. Twenty‐four 160 ± 10 g, six wistar albino male rats in each group were kept: NC (control sample, no onion powder), OT1, OT2, and OT3, which contained 11.13, 14.84, and 18.61 g/100 g onion powder, respectively. The treatment lasted 28 days, during which the last 7 days were for urine, feces, and blood collection. The results showed a trend of decreasing levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, total bilirubin, total cholesterol, and low‐density lipoprotein in rats fed OT1, OT2, and OT3 diets. Improvements were observed in feed, water, and nutrient intake, feed conversion ratio, feed efficiency ratio, nutrient digestibility, nitrogen balance, body weight, blood urea nitrogen, creatinine, and uric acid levels (p ≤ .05). In contrast, high‐density lipoprotein, triglycerides, serum total protein, neutrophils, and lymphocytes did not change (p ≥ .05). White blood cells, red blood cell count, platelet count, hemoglobin, and monocytes showed an upward trend. Based on our calculations, we determined the optimal human dosage from the most effective amount of onion powder. By taking into account the ratio of human‐to‐rat surface area, we estimate that the equivalent human dose of onion is 181.04 grams with 204 mg of quercetin. Additionally, when factoring in the dry matter content, the recommended dose of onion is 29.19 grams with 220 mg of quercetin.