bluuebunny/crossref_metadata_2025_split huggingface dataset:
Las Parrandas del Centro de Cuba: un recurso para la diversificación de la oferta turística y el desarrollo local
Authors: Hernández Martínez Damián , Rios Ramírez José Antonio , Pérez García Maikol Manuel 
Published: February 2024

Introducción: Las Parrandas del Centro de Cuba declaradas Patrimonio Inmaterial de la Humanidad surgen por primera vez en 1820 en Remedios y son fiestas celebradas por dieciocho pueblos de tres provincias del país: Villa Clara, Sancti Spíritus y Ciego de Ávila. Del total de dieciocho parrandas solamente la de San Juan de los Remedios, por ser la cuna de las mismas es explotada como un atractivo, dando prueba de ello, los antecedentes de la presente investigación que solo analizan el potencial turístico de la festividad de la Octava Villa de Cuba y no así el del resto de las parrandas. Objetivo: El objetivo de la investigación es demostrar las potencialidades de las Parrandas del Centro de Cuba como un recurso para la diversificación de la oferta turística y el desarrollo local. Metodología: Dentro de los métodos empleados están los del nivel teórico como el análisis y síntesis de documentos que fundamentan la investigación, además se utilizaron métodos empíricos como la observación directa y entrevistas a la población local y funcionarios de varias instituciones vinculadas al patrimonio inmaterial. Resultados: La inclusión de estas dentro de la oferta turística generaría resultados positivos como mayores ingresos a la población de acogida reflejados en el desarrollo de la artesanía, la cultura gastronómica, así como mejoras a la infraestructura de dichos territorios. Para ello se hizo necesario esclarecer las distancias con los principales destinos consolidados en la región, las vías de acceso, se crearon canales de información para el conocimiento de dicha tradición dado la influencia actual de las redes sociales y se orientó el cálculo de una adecuada capacidad de carga para evitar consecuencias negativas relacionadas al turismo cultural. Conclusión: Esta investigación constituye un antecedente para la elaboración de La Ruta de las Parrandas como un futuro producto integrado de la Región Central de Cuba. Área de estudio general: Turismo. Área de estudio específica: Turismo Cultural
Effectiveness of Cognitive Behavior Group Therapy in Reducing the Risk of Eating Disorder among University Students
Authors: Zaman Fatema Tu Zohra Binte , Rakib Shahriar Hasan 
Published: February 2024

Eating disorders are serious mental illnesses that typically originate during adolescence, often persist over an extended period, and significantly affect one's overall well-being. These disorders contribute significantly to the worldwide health burden. Despite a rising number of individuals seeking treatment for eating disorders, there is limited study regarding the effectiveness of therapy in preventive measures of the risk of eating disorders. Therefore, this research aims to study the effectiveness of cognitive behavior group therapy (CBGT) in reducing the risk of eating disorders among university students. Using a pretest-posttest with a control group design. The adapted Bangla version of the Eating Attitude Test (EAT-26) was utilized and socio-demographic data for all participants at the baseline and post-intervention. Thirty-six participants i.e., university students with a risk of eating disorders were chosen by purposive sampling. Participants were randomly assigned into two groups (intervention and non-intervention groups). However, the experimental (intervention) group (n = 18) received cognitive behavioral group therapy, and the control also known as the non-interventional group (n = 18) did not. To analyze the obtained data descriptive statistics, independent sample t-test, and paired sample t-test were performed. Findings showed that receiving CBGT sessions significantly reduced eating disorder risk in the intervention group. However, there is no difference in the risk of eating disorders in the pre-test and post-test of the non-intervention group was observed. This study's findings emphasize the importance and effectiveness of cognitive behavior group therapy in addressing and mitigating the risk of eating disorders among university students.
Jagannath University Journal of Science, Volume 10, Number II, Dec. 2023, pp. 124−135
PELAYANAN DOKUMEN PAKET KEMATIAN MELALUI PROGRAM SEDUDO DI DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN NGANJUK PROVINSI JAWA TIMUR
Authors: Hutasoit Imelda , Pribadi Ari Samudro 
Published: February 2024

Selain untuk berbagai kepentingan keluarga, pengurusan dokumen kematian berupa Akta Kematian sangat diperlukan agar kondisi nyata penduduk tergambarkan secara valid. Namun angka kepemilikan dokumen kependudukan khususnya peristiwa kematian hanya mencapai 32,70%. Tujuan penelitian ini untuk menganalisis pelayanan dokumen paket kematian melalui program SEDUDO yang ditinjau melalui 4 dimensi yakni efisien, ekonomi, keadilan dan efektivitas. Metode penelitian yang digunakan dalam penelitian ini adalah Deskriptif Kualitatif. Pengumpulan data menggunakan beberapa cara yaitu observasi, wawancara, dan dokumentasi. Teknik analisis dilakukan dengan menggunakan beberapa tahapan yaitu mempersiapkan data, membaca keseluruhan data, penyajian data, coding atau mengorganisasikan data, menganalisis data, mendeskripsikan data yang telah di analisis, dan pembuatan interpretasi atau penarikan kesimpulan. Dalam penelitian ini, pelayanan dokumen paket kematian belum optimal karena terdapat beberapa permasalahan diantaranya sarana dan prasarana yang belum maksimal akibat adanya beberapa pegawai yang merangkap pekerjaan dan ada juga yang tidak sesuai tugas dan fungsinya, kurangnya respon admin dalam menanggapi keluhan tentang program SEDUDO, sehingga kepemilikan dokumen paket kematian di Kabupaten Nganjuk belum pernah mencapai target sempurna. Beberapa upaya juga telah dilakukan adalah peningkatan sarana dan prasarana, meningkatkan peran sosial media dalam sosialisasi terkait dengan program SEDUDO dan meningkatkan peran RT dalam pelaporan dan pendaftaran pembuatan dokumen paket kematian. Saran yang diberikan yaitu pembaharuan dan implementasi regulasi, melaksanakan sosialisasi, serta meningkatkan kualitas sumber daya manusia maupun sarana dan prasarana yang ada.
Acid hydrolysis of Solanum tuberosum periderm for accumulation of polyhydroxyalkanoates in Pseudomonas putida MTCC 2475
Authors: Kag Sonika , Kumar Pravir , Kataria Rashmi 
Published: February 2024

Polyhydroxyalkanoates are a class of biodegradable, biocompatible polymers composed of polyesters of R-hydroxyalkanoic acids and deposited intracellularly by a variety of microorganisms which have potential to serve as alternative to commercial plastic. Bioplastics are gaining attention due to sustainability, biodegradability, biocompatibility, and lower carbon footprint. Nevertheless, the commercialization of PHA is predominantly hindered by the elevated production expenses arising primarily from the use of a pure sugar substrate. Our study has established a feasible method for bioplastic formation applying Pseudomonas putida MTCC 2475 and Solanum tuberosum periderm as a carbon source. To optimize the sugar yield response surface methodology was used, which released 69.34% ± 0.25% reducing sugar. PHA production experiments were performed in hydrolysate containing media as well as commercial sugar containing mineral salt media. After 48 h of fermentation of using this sugar, a biomass concentration of 2.19 gL−1, with a PHA production of 0.60 gL−1 (28.71% ± 0.55%) was obtained which was comparatively similar with synthetic media (2.56 gL−1 cell dry weight and 29.97% ± 0.45% PHA). Furthermore, the monomers of PHA produced by hydrolysate were characterized using Gas chromatography-mass spectrometry, Fourier transform infrared spectroscopy, differential scanning calorimetry, and nuclear magnetic resonance. This investigation has identified three distinct monomers of medium-chain PHAs, namely, methyl 3-Hydroxydodecanoate, 3-Hydroxytetradecanoate, and Hexadecanoic acid 3-Hydroxy methyl esters. Hence this study concludes a sustainable production of bioplastics from S. tuberosum periderm waste.
Extremely low-frequency electromagnetic fields facilitate both osteoblast and osteoclast activity through Wnt/β-catenin signaling in the zebrafish scale
Authors: Kobayashi-Sun Jingjing , Kobayashi Isao , Kashima Makoto , Hirayama Jun , Kakikawa Makiko , Yamada Sotoshi , Suzuki Nobuo 
Published: February 2024

Electromagnetic fields (EMFs) have received widespread attention as effective, noninvasive, and safe therapies across a range of clinical applications for bone disorders. However, due to the various frequencies of devices, their effects on tissues/cells are vary, which has been a bottleneck in understanding the effects of EMFs on bone tissue. Here, we developed an in vivo model system using zebrafish scales to investigate the effects of extremely low-frequency EMFs (ELF-EMFs) on fracture healing. Exposure to 10 millitesla (mT) of ELF-EMFs at 60 Hz increased the number of both osteoblasts and osteoclasts in the fractured scale, whereas 3 or 30 mT did not. Gene expression analysis revealed that exposure to 10 mT ELF-EMFs upregulated wnt10b and Wnt target genes in the fractured scale. Moreover, β-catenin expression was enhanced by ELF-EMFs predominantly at the fracture site of the zebrafish scale. Inhibition of Wnt/β-catenin signaling by IWR-1-endo treatment reduced both osteoblasts and osteoclasts in the fractured scale exposed to ELF-EMFs. These results suggest that ELF-EMFs promote both osteoblast and osteoclast activity through activation of Wnt/β-catenin signaling in fracture healing. Our data provide in vivo evidence that ELF-EMFs generated with a widely used commercial AC power supply have a facilitative effect on fracture healing.
Leveraging baseline transcriptional features and information from single-cell data to power the prediction of influenza vaccine response
Authors: Ye Xiangyu , Yang Sheng , Tu Junlan , Xu Lei , Wang Yifan , Chen Hongbo , Yu Rongbin , Huang Peng 
Published: February 2024

IntroductionVaccination is still the primary means for preventing influenza virus infection, but the protective effects vary greatly among individuals. Identifying individuals at risk of low response to influenza vaccination is important. This study aimed to explore improved strategies for constructing predictive models of influenza vaccine response using gene expression data.MethodsWe first used gene expression and immune response data from the Immune Signatures Data Resource (IS2) to define influenza vaccine response-related transcriptional expression and alteration features at different time points across vaccination via differential expression analysis. Then, we mapped these features to single-cell resolution using additional published single-cell data to investigate the possible mechanism. Finally, we explored the potential of these identified transcriptional features in predicting influenza vaccine response. We used several modeling strategies and also attempted to leverage the information from single-cell RNA sequencing (scRNA-seq) data to optimize the predictive models.ResultsThe results showed that models based on genes showing differential expression (DEGs) or fold change (DFGs) at day 7 post-vaccination performed the best in internal validation, while models based on DFGs had a better performance in external validation than those based on DEGs. In addition, incorporating baseline predictors could improve the performance of models based on days 1–3, while the model based on the expression profile of plasma cells deconvoluted from the model that used DEGs at day 7 as predictors showed an improved performance in external validation.ConclusionOur study emphasizes the value of using combination modeling strategy and leveraging information from single-cell levels in constructing influenza vaccine response predictive models.
The role of type VI secretion system genes in antibiotic resistance and virulence in Acinetobacter baumannii clinical isolates
Authors: Li Pu , Zhang Sirui , Wang Jingdan , Al-Shamiri Mona Mohamed , Luo Kai , Liu Shuyan , Mi Peng , Wu Xiaokang , Liu Haiping , Tian Huohuan , Han Bei , Lei Jin’e , Han Shaoshan , Han Lei 
Published: February 2024

IntroductionThe type VI secretion system (T6SS) is a crucial virulence factor in the nosocomial pathogen Acinetobacter baumannii. However, its association with drug resistance is less well known. Notably, the roles that different T6SS components play in the process of antimicrobial resistance, as well as in virulence, have not been systematically revealed.MethodsThe importance of three representative T6SS core genes involved in the drug resistance and virulence of A. baumannii, namely, tssB, tssD (hcp), and tssM was elucidated.ResultsA higher ratio of the three core genes was detected in drug-resistant strains than in susceptible strains among our 114 A. baumannii clinical isolates. Upon deletion of tssB in AB795639, increased antimicrobial resistance to cefuroxime and ceftriaxone was observed, alongside reduced resistance to gentamicin. The ΔtssD mutant showed decreased resistance to ciprofloxacin, norfloxacin, ofloxacin, tetracycline, and doxycycline, but increased resistance to tobramycin and streptomycin. The tssM-lacking mutant showed an increased sensitivity to ofloxacin, polymyxin B, and furazolidone. In addition, a significant reduction in biofilm formation was observed only with the ΔtssM mutant. Moreover, the ΔtssM strain, followed by the ΔtssD mutant, showed decreased survival in human serum, with attenuated competition with Escherichia coli and impaired lethality in Galleria mellonella.DiscussionThe above results suggest that T6SS plays an important role, participating in the antibiotic resistance of A. baumannii, especially in terms of intrinsic resistance. Meanwhile, tssM and tssD contribute to bacterial virulence to a greater degree, with tssM being associated with greater importance.
Distinguishing heart failure subtypes: the diagnostic power of different cardiac magnetic resonance imaging parameters
Authors: Hao Yanhui , Zhang Rui , Chen Lihong , Fan Ganglian , Liu Bing , Jiang Ke , Zhu Yi , Zhang Ming , Guo Jianxin 
Published: February 2024

ObjectivesThe aim of this retrospective study was to explore the diagnostic potential of various cardiac parameters in differentiating between heart failure with preserved ejection fraction (HFpEF) and heart failure with mid-ranged and reduced ejection fraction (HFm + rEF), and to discern their relationship with normal cardiac function.MethodsThis research encompassed a comparative analysis of heart failure subtypes based on multiple indicators. Participants were categorized into HFm + rEF, HFpEF, and control groups. For each participant, we investigated indicators of left ventricular function (LVEDVi, LVESVi, and LVEF) and myocardial strain parameters (GLS, GCS, GRS). Additionally, quantitative tissue evaluation parameters including native T1, enhanced T1, and extracellular volume (ECV) were examined.For comprehensive diagnostic performance analysis, receiver operating characteristic (ROC) curve evaluations for each parameters were conducted.ResultsHFm + rEF patients exhibited elevated LVEDVi and LVESVi and decreased LVEF compared to both HFpEF and control groups. Myocardial strain revealed significant reductions in GLS, GCS, and GRS for HFm + rEF patients compared to the other groups. HFpEF patients showed strain reductions relative to the control group. In cardiac magnetic resonance imaging (CMR) evaluations, HFm + rEF patients demonstrated heightened native T1 times and ECV fractions. Native T1 was particularly effective in distinguishing HFpEF from healthy subjects.ConclusionNative T1, ECV, and myocardial strain parameters have substantial diagnostic value in identifying HFpEF. Among them, native T1 displayed superior diagnostic efficiency relative to ECV, offering critical insights into early-stage HFpEF. These findings can play a pivotal role in refining clinical management and treatment strategies for heart failure patients.
Impact on green finance and environmental regulation on carbon emissions: evidence from China
Authors: Guo Xiaoyang , Yang Jingyi , Shen Yang , Zhang Xiuwu 
Published: February 2024

Introduction: Achieving peak carbon dioxide emissions and carbon neutrality is an extensive and profound systematic economic and social change. Through market-oriented financial means, green finance has moved forward the effective governance port, curbed polluting investment and promoted technological progress such as green low-carbon, energy conservation and environmental protection, which has become a powerful starting point to support the practice of low-carbon development.Methods: Based on the panel data of 30 provinces in China (except Tibet, Hongkong, Macau and Taiwan Province) from 2004 to 2021, this paper calculates the development level of green finance in China provinces by using entropy weight method, and on this basis, uses mathematical statistical model to verify the impact of green finance and its sub-dimensions on carbon emissions and the regulatory effect of heterogeneous environmental regulation tools.Results: The results show that the development of green finance has a significant inhibitory effect on carbon emissions during the investigation period, and there is a time lag effect. After a series of robustness tests and considering endogenous problems, this conclusion still holds. From the results of heterogeneity analysis, the carbon emission reduction effect of green credit is the most obvious, and the impact of green finance on carbon emission is slightly different in different regions. Besides, Command-controlled environmental regulation tools and public participation environmental regulation tools play a positive regulatory role in the transmission path of green finance’s impact on carbon emissions, but market-driven environmental regulation tools cannot effectively enhance the carbon emission reduction effect of green finance development.Discussion: The research results of this paper provide a basis for the government to formulate flexible, accurate, reasonable and appropriate green financial policies, help to strengthen the exchange and cooperation between regions in reducing carbon and fixing carbon, and actively and steadily promote China’s goal of “peak carbon dioxide emissions, carbon neutrality”.
Quantitative analysis of ecological compensation in the Yangtze River Delta region based on the value of ecosystem services and ecological footprint
Authors: Mao Chunmei , Niu Junjun 
Published: February 2024

IntroductionThe Yangtze River Delta is where “the Belt and Road” and China’s Yangtze River Economic Belt converge, which plays a crucial strategic location. However, with the demands of economic growth, environmental issues are frequently present in the Yangtze River Delta as a result of human and exploitation of ecological resources, and there is an urgent need to coordinate the relationship between human development and ecology.MethodsThe Yangtze River Delta region is used as the research subject, quantitatively analyzing various ecosystems within the region from three dimensions: ecosystem services value, ecological carrying capacity, and ecological footprint, and analyzing various factors that affect economic and environmental balance. Then calculate eco-compensation and its payment order based on this information, in order to build a foundation for coordinating ecological interests and safeguarding the environment in the Yangtze River Delta region.Results and discussion(1) Jiangsu Province was the main provider of ecosystem services in the Yangtze River Delta; the Yangtze River Delta’s three main ecosystems-waters, forests, and wetlands-accounted for 90% of the ecosystem services valued in the area and must be preserved. (2) The Yangtze River Delta as a whole belonged to an ecological deficit area, showing varying degrees of unsustainable development; In terms of ecological deficits, cultivated land and fossil energy had the worst, and both need to be treated severely. (3) The Yangtze River Delta was a region that paid ecological compensation. The payment order and total amount was 6825.596 billion yuan in Shanghai, 6412.264 billion yuan in Jiangsu, 12088.852 billion yuan in Zhejiang, and 3675.637 billion yuan in Anhui. At the same time, considering the current state of Anhui, the amount of eco-compensation can be appropriately reduced. Finally, recommendations are made based on the findings above, in order to improve the overall ecological benefits of the Yangtze River Delta region and foster ecological integration, all provincial and municipal governments should take reasonable action to reverse the ecological deficit of fossil energy and cultivated land, and also aim to achieve an ecological surplus in both land uses.
Major cardiovascular events under biologic psoriasis therapies: a 19-year real-world analysis of FAERS data
Authors: Ding Lingqing , Chen Congqin , Yang Yongkuan , Zhang Xiaoting 
Published: February 2024

ObjectiveOver the years when biologic psoriasis therapies (TNF inhibitors, IL-12/23 inhibitors, IL-23 inhibitors, and IL-17 inhibitors) have been used in psoriasis patients, reports of major cardiovascular events (MACEs) have emerged. This study aims to investigate the association between MACEs and biologic psoriasis therapies by using information reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS).MethodsFAERS data (January 2004 to December 2022) were reviewed. For each drug–event pair, the proportional reporting ratio (PRR) and the multi-item gamma Poisson shrinker (MGPS) algorithms were used to identify drug–adverse event associations.ResultsWe filtered the query for indication and identified 173,330 reports with psoriasis indication in FAERS throughout the analyzed time frame. MACEs occurred in 4,206 patients treated with biologics. All the four biological classes had an elevated and similar reporting rates for MACEs relative to other alternative psoriasis treatments (PRR from 2.10 to 4.26; EB05 from 1.15 to 2.45). The descending order of association was IL-12/23 inhibitors&gt;IL-17 inhibitors&gt;IL-23 inhibitors&gt;TNF inhibitors. The signal strength for myocardial infarction (PRR, 2.86; χ2, 296.27; EBGM 05, 1.13) was stronger than that for stroke, cardiac fatality, and death. All the biological classes demonstrated a little higher EBGM 05 score≥1 for the MACEs in patients aged 45–64 years. The time-to-onset of MACEs was calculated with a median of 228 days.ConclusionsAnalysis of adverse event reports in the FAERS reflects the potential risk of MACEs associated with the real-world use of biological therapies in comparison to other alternative psoriasis treatments. Future long-term and well-designed studies are needed to further our knowledge regarding the cardiovascular safety profile of these agents.