bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic status and adiposity in childhood cancer survivors: A cross-sectional retrospective study
Authors: Štrublová Lucie , Kepák Tomáš , Kuruczová Daniela , Zlámal Filip , Holíková Marta , Kepáková Kateřina , Štěrba Jaroslav , Bienertová-Vašků Julie 
Published: February 2024

This is a retrospective cross-sectional study examining the association between unemployment, cancer type, treatment and total body fat percentage of childhood cancer survivors recruited at St. Anne’s University Hospital in Brno, Czech Republic. A total of 55 survivors aged 18–49 who were in remission of cancer and fulfilled the criteria for body composition measurements by the BIA and completed questionnaires investigating their socioeconomic status, employment status, and history. There was a significant relationship between the employment status and central nervous system-directed treatment (c2(1) = 7.53, p = 0.006, Cramér’s V = 0.38) and between the type of cancer and employment status (c2(3) = 7.83, p = 0.049, Cramér’s V = 0.38), the highest unemployment rate was recorded for brain and spine survivors (72.7%) compared to survivors with other diagnosis (35.7%) (uLR(1) = 4.91, p = 0.027; OR = 4.80, 95% CI:1.10–20.86, p = 0.036); these survivors did not have a significantly different body fat percentage compared to survivors with other diagnoses (t(53) = 1.29, p = 0.202, Cohen’s d = 0.41) Interestingly, the survivors reporting having a partner also had a significantly higher percentage of body fat (t(53) = 2.90, p = 0.005, Cohen’s d = 0.81). A linear regression model was used to model the percentage of body fat in relation to a set of selected variables and the we observed a significant effect of sex (female vs male: b = 6.37, 95% CI: 1.82–10.93, p = 0.007), partnership status (yes vs no: b = 5.65, 95% CI: 0.67–10.62, p = 0.027) and category of diagnosis (Brain and spinal column tumors vs Other solid tumors: b = 12.40, 95% CI: 0.59–24.21, p = 0.040; Brain and spinal column tumors vs Lymphoma: b = 14.02, 95% CI: 2.06–25.97, p = 0.023). Employment status and risk of adiposity in childhood cancer survivors depends on the type of treatment and diagnosis group, which may significantly impact their lifestyle and overall quality of life after treatment.
Trial registration: This study was registered on July 29, 2022, at ClinicalTrials.gov (NCT05481229).
Cytokine Release Syndrome–Associated Colitis: Insights From a Case of Rituximab-Induced Pancolitis
Authors: Vikash Fnu , Vikash Sindhu , Mintz Michael , Elshafey Suzanne , Kim Daniel , Wan David 
Published: February 2024

ABSTRACT
Rituximab (RTX), a widely used monoclonal antibody for hematologic malignancies and rheumatologic disorders, is known for infusion-related reactions. However, its potential to induce colitis is often overlooked. We present an 85-year-old woman with chronic lymphocytic leukemia experiencing severe adverse effects during her fourth RTX infusion, including abdominal pain, hypotension, and bright red blood per rectum. Computed tomography of the abdomen and pelvis with contrast revealed pancolonic mural wall thickening without perforation. Prompt treatment with vasopressors and intravenous fluids led to symptom resolution within 24 hours. We highlighted the importance of recognizing RTX-induced colitis and discussed and depicted immunological dysregulation mechanisms involved.
Differences in Mucosal Permeability Among Patients With Ulcerative Colitis Classified Based on the Colonic Location and Disease Activity
Authors: Shiratori Wataru , Ohta Yuki , Matsusaka Keisuke , Ohyama Yuhei , Mamiya Yukiyo , Nakazawa Hayato , Takahashi Satsuki , Horio Ryosuke , Goto Chihiro , Sonoda Michiko , Kurosugi Akane , Kaneko Tatsuya , Akizue Naoki , Ishigami Hideaki , Taida Takashi , Okimoto Kenichiro , Saito Keiko , Matsumura Tomoaki , Shiko Yuki , Ozawa Yoshihito , Kato Jun , Ikeda Junichiro , Kato Naoya 
Published: February 2024

INTRODUCTION:
Factors affecting mucosal permeability (MP) in ulcerative colitis (UC) are largely unknown. We aimed to investigate the difference in MP among patients with UC classified according to the colonic locations and to evaluate the correlations between local MP and endoscopic or histological activity of UC.

METHODS:
The transepithelial electrical resistance (TER), which is inversely proportional to permeability, of tissue samples from the mucosa of the ascending colon, descending colon, and rectum of patients with UC and healthy individuals (HIs) was measured by using the Ussing chamber. TERs were compared between patients with UC and HIs and evaluated according to colonic locations and disease activity of UC.

RESULTS:
Thirty-eight patients with UC and 12 HIs were included in this study. Both in HIs and patients with UC, MP tends to be higher in the anal side. TER in the ascending colon was significantly lower in patients with UC than in HIs (45.3 ± 9.0 Ω × cm2 vs 53.5 ± 9.7 Ω × cm2, P = 0.01). The increased permeability in UC was observed also in the descending colon, only when the inflammation involved the location. A significant correlation between TER and endoscopic activity was found in the rectum only (r = −0.49, P = 0.002). There were no significant correlations between TERs and UC histology.

DISCUSSION:
The MP in the colon differs according to the colonic location. The ascending colon among patients with UC showed disease-specific changes in MP, whereas the MP is increased in proportion to the endoscopic activity in the rectum.
The Arm’s Length Principle – An Adequate Means for Taxing Multinational Corporate Groups?
Authors: Sander Hendrik , Scherer Anna-Lena , Schmiel Ute 
Published: February 2024

Abstract
International tax law is characterized by the arm’s length principle. However, the arm’s length principle is highly criticized since it is seen as a major driver of tax avoidance. Although the OECD’s Two-Pillar Solution and EU initiatives seem to indicate that international tax law is in a state of change, the arm’s length principle remains relevant. Therefore, we deal with the question whether it is possible to improve the arm’s length principle. While previous attempts ask, for example, whether it is possible to reduce its complexity, we focus on the aspect that the OECD Transfer Pricing Guidelines do not refer to a theory of the formation of prices in transactions between independent parties. We advocate developing a theoretical substantiation and introduce a new interpretation of the arm’s length principle, based mainly on concepts of a general evolutionary theory and political-cultural market theory. This reference to an adequate market theory leads us to a new interpretation of the arm’s length principle that differs considerably from the current interpretation. Still, we doubt that this new interpretation of the arm’s length principle alone can reduce tax avoidance significantly. However, understood as one instrument in a mix of instruments, we estimate that this interpretation of the arm’s length principle constitutes a more adequate means for fighting tax avoidance of multinational corporate groups than its current interpretation.
Sulfate removal from wastewater by using waste material as an adsorbent
Authors: Obeid Ashraf Fakhri , Nile Basim Khalil , Farouk Maad 
Published: February 2024

Abstract
A new composite adsorbent was created by activating bentonite, a sludge, to improve its adsorption capability. These innovative adsorbents address sulfate ion pollution in wastewater treatment. Researchers used various techniques to study the composite’s surface structure, chemical, elemental, and mineralogical characteristics. The composite adsorbs over 864 mg/L of sulfate ions from wastewater with an initial concentration of 900 mg/L, demonstrating its high removal efficiency of 96%.
Multi-Dimensional Regularity Analysis: How the Entrenchment-and-Conventionalization Model can be applied to corpus data
Authors: Schmid Hans-Jörg 
Published: February 2024

Abstract
This paper introduces and illustrates a methodology for analyzing corpus data with the goal of identifying regularities in the use of a given element or pattern. In line with the research tradition in construction grammar, one type of these regularities pertains to form-meaning and/or form-function pairings. In addition to this, however, further types of regularities are explored, among them the reciprocal type of regularity that links communicative goals and linguistic forms as well as contextual and social regularities. I pursue three main goals: 1) to lay out the conceptual groundwork of the methodology; 2) to present a manual for applying it; and 3) to illustrate its application with a case study on the sequence in here. The motivation for developing this methodology, labelled Multi-Dimensional Regularity Analysis (MDRA), lies in the dynamic, flexible and multi-dimensional notion of linguistic conventions and conventional constructions proposed as part of the Entrenchment-and-Conventionalization Model (Schmid 2020).
Dimensions of constructional meanings in the German Constructicon: Why collo-profiles matter
Authors: Ziem Alexander , Feldmüller Tim 
Published: February 2024

Abstract

A constructicon, i.e., a structured inventory of constructions, essentially aims at documenting functions of lexical and grammatical constructions. Among other parameters, so-called constructional collo-profiles, as introduced by Herbst (2018, 2020), are conclusive for determining constructional meanings. They provide information on how relevant individual words are for construction slots, they hint at usage preferences of constructions and serve as a helpful indicator for semantic peculiarities of constructions. However, even though collo-profiles constitute an indispensable component of constructicon entries, they pose major challengers for constructicographers: For a constructicographic enterprise it is not feasible to conduct collostructional analyses for hundreds or even thousands of constructions. In this article, we introduce a procedure based on the large language model BERT that allows to predict collo-profiles without having to extensively annotate instances of constructions in a given corpus. Specifically, by discussing the constructions
X macht Y ADJP (‘x makes Y ADJ’, e.g. he drives him crazy) and N1 PREP N1
(e.g., bumper to bumper, constructions over constructions), we show how the developed automated system generates collo-profiles based on a limited number of annotated instances. Finally, we place collo-profiles alongside other dimensions of constructional meanings included in the German Constructicon.
Extraction of 4-hydroxy benzoic acid from potato processing industrial waste
Authors: Dadhe Praful S. , Mandavgane Sachin A. , Kumar Anupama 
Published: February 2024

Abstract
Due to the substantial volume of waste produced and the potential for high-value bioactive compounds to be extracted from potato peel, the valorization of industrial waste of potato processing industry is the subject of this research. The study presents an innovative technique for efficient extraction of 4-hydroxybenzoic acid (P-HBA), a valuable bioactive molecule, from potato peel extract by utilizing molecularly imprinted chitosan beads (MICB). The MICB was synthesized using environmentally benign cross-linkers such as Tetraethyl orthosilicate (TEOS), Sodium triphosphate (STPP), while P-HBA was is used as a template. The MICB was investigated using FTIR, SEM, and EDAX. Adsorption studies were conducted to optimize parameters like adsorbent dose, solution concentration, time and pH. A recovery rate of 95.07 % is recorded from a synthetic P-HBA solution when measured by HPLC while from the actual potato processing industrial effluent the same is 40 %. The adsorption capacity of MICB is 67.5 mg g−1 and specific binding capacity is 20.62 mg g−1 which remained unchanged for six consecutive cycle reuse. This is the first study to report uptake of a bioactive molecule from actual potato processing industry waste.
Generic flame extension model development based on machine learning for NPPs fire hazard analysis (FHA)
Authors: Sharma Pavan K. 
Published: February 2024

Abstract
In enclosed fire situations, the flame interacts with ceiling and its length extension take place, altering the fire severity significantly. Fire safety analysis demand a generic flame extension model. A generic reliable model is not available as the construct of flame itself had wide variation in literature. The present paper aims to develop a Machine Learning (ML) based generic model of non-dimensional flame extension as a function of non-dimensional Heat Release Rate (HRR). The non-dimensional scaling reduces the number of parameter and also provide a generic nature. Literature review was utilized to collect the data from various open literature sources. This eliminates the limitations of individual correlations and gives a best optimized model which is valid for a wide range of flow regimes and conditions as compared to a specific correlation. Various simple ML models are compared for their performance against test data and a MARS based model was finally recommended. The MARS model was tested against the data which was not used in training and also against the other reported correlation. The developed model has performed well against the test data and marked improvement over other reported correlation as a better optimized performance over an extended range of non-dimensional range. The results of the model were also conservative as compared to another model in the most of the practical requirement of NPPs. A Large Eddy Simulation (LES) based CFD code FDS was also used to generate the flame extension data for demonstrating conservative nature of the ML model.
A novel multicore Er/Yb co-doped microstructured optical fiber amplifier with peanut-shaped air holes cladding
Authors: Zhang Yifan , Zhao Yifei , Fang Ziwei , Liu Jiantao , Xia Changming , Hou Zhiyun , Zhao Xuesong , Tan Zhongwei , Dong Yi , Zhou Guiyao , Yuan Jinhui 
Published: February 2024

Abstract
The multicore fiber amplifier, as a key component in spatial division multiplexing (SDM) communication systems, presents higher technical difficulty compared to traditional multi-channel single core fiber amplifiers, which has sparked widespread attention. To achieve balance, efficiency, miniaturization, and cost-effectiveness in the performance of multi-core optical fiber amplifiers, we propose an innovative triple cladding 13-core Er/Yb co-doped microstructured fiber (13CEYDMOF). The proposed fiber features an outer cladding with peanut-shaped air holes, which enables uniform excitation of the 13 cores using a single multimode laser pump source within the inner cladding. This approach also prevents damage or aging of the fiber’s outer coating due to the pump laser. Furthermore, the design of Peanut-Shaped Air Holes effectively increases the numerical aperture (NA) of the inner cladding while reducing the outer diameter of the fiber, enhancing the fiber’s mechanical flexibility. To address the coupling difficulties caused by air holes, we bi-directionally pump the 13CEYDMOFA by utilizing a combined technique of the side winding and end pumping. The experimental results show that the 13CEYDMOFA can achieve an average gain of 23.8 dB, a noise figure (NF) of ∼4.6 dB, and an inter-core gain difference of less than 2 dB in the wavelength range of 1529–1565 nm. The in-line amplified transmission experiment demonstrates that the 13CEYDMOFA is well suited for the 13 spatial channels transmission. To the best of our knowledge, this is the first time to realize high performance telecommunication band amplification in a multicore microstructure fiber.
Formation of hollow silver nanoparticles under irradiation with ultrashort laser pulses
Authors: Sánchez-Pérez Francisco , Borrell-Grueiro Olivia , Casasnovas-Melián Alfredo , Ramos-Ramos Diego J. , Guerrero-Martínez Andrés , Bañares Luis , Prada Alejandro , Valencia Felipe J. , Kohanoff Jorge , Crespillo Miguel L. , Olivares José , Rivera Antonio , Peña-Rodríguez Ovidio 
Published: February 2024

Abstract
We have studied the formation of cavities in spherical silver nanoparticles embedded in silica, irradiated with fs laser pulses that produce an intense electronic excitation. Experimentally determined aspect ratio, i.e. the ratio between the cavity and nanoparticle size, for hollow structures formed under different irradiation conditions shows a very good agreement with values obtained by means of atomistic simulations. According to the predictions of the atomistic model, one can produce at will hollow silver nanoparticles with cavities of tailored dimensions, having an accurate control. Hence, laser irradiation can be used to control and design the optical response by tuning the localized surface plasmon resonances of the hollow nanoparticles.
Hyperthyroidism and the risk of non-thyroid cancer: a Danish register-based long-term follow-up study
Authors: Riis Thea , Bonnema Steen Joop , Brix Thomas Heiberg , Folkestad Lars 
Published: February 2024

Objective
Cancer is the second most common cause of death worldwide. It is currently debated whether thyroid dysfunction is a modifiable cancer risk factor. Our aim was to evaluate the risk of cancer in patients with hyperthyroidism.

Methods
This is a register-based nationwide cohort study of individuals with a diagnosis of hyperthyroidism. Each hyperthyroid case was matched with four reference individuals according to age and sex. Using Fine and Gray competing risk regression models, we studied the association of hyperthyroidism and subsequent all-cause cancer diagnoses, adjusted for preexisting morbidity. Sub-analyses were stratified for cause of hyperthyroidism (Graves’ disease and toxic nodular goiter, age when diagnosed with hyperthyroidism, sex, and cancer localization (lung, prostate, breast, and colorectal cancer)).

Results
The cohort consisted of 95,469 patients with hyperthyroidism (followed for a median of 10.9 years (range: 5.2–17.2)), and 364,494 reference individuals (followed for a median of 11.2 years (range: 5.4–17.4)). Hyperthyroidism was associated with increased all-cause cancer risk (sub-distribution hazard ratio (SHR): 1.12; 95% CI: 1.10–1.14), as well as an increased risk of breast (SHR: 1.07; 95% CI: 1.02–1.13), lung (SHR: 1.20; 95% CI: 1.16–1.26), and prostate cancer (SHR: 1.10; 95% CI: 1.02–1.19), but not colorectal cancer (SHR: 1.04; 95% CI: 0.99–1.09). Sub-analyses stratified for age when diagnosed with hyperthyroidism and cause of hyperthyroidism yielded similar results.

Conclusion
In this register-based study, patients with hyperthyroidism had an increased risk of cancer, in particular lung, prostate, and breast cancer. Whether a causal link exists remains to be proven.
Propuesta para el Diseño del “Ecomuseo Los Chorotegas” en el Territorio Indígena Matambú, Guanacaste-Costa Rica
Authors: Murillo Cinthya 
Published: February 2024

Over time, human geography has played a fundamental role in communities’ processes of adaptation to their environment. This involves considerations spanning the modification of territories, social organization, and economic activities such as cultural tourism. This also involves understanding the geographic context of their history and culture to add value to communities’ knowledge and processes. Therefore, this article proposes the creation of a Chorotega Culture Eco-Museum in Matambú, a community located within the South Guanacaste Unit of Touristic Planning, Costa Rica. This proposal arises from the necessity of this indigenous community to be part of the tourism industry as a survival strategy. The objective is to promote ecotourism and cultural and creative tourism in the Matambú Chorotega Indigenous Territory (TICM). This initiative serves as a method to enhance the socio-economic conditions of the indigenous community while helping to preserve and rescue the sense of belonging to its cultural and natural heritage.
By achieving the objective of creating “Los Chorotegas” Eco-Museum in the Matambú community, this territory and indigenous group will be respected and valued as the only remaining ethnicity of Mesoamerican origin within Costa Rica, and this recognition can improve their quality of life.
El fenómeno ENOS y el análisis de la variabilidad de las series de tiempo de precipitación en el Área de Conservación Guanacaste, Costa Rica.
Authors: Vega-Araya Mauricio 
Published: February 2024

The Pacific Northwest of Costa Rica is a region with marked seasonality in rainfall patterns. This area of Costa Rica is prone to extreme hydroclimatic phenomena such as droughts and floods. Due to the limited distribution of rainfall gauges and the unavailability of relevant information, complementary data obtained from satellites and their respective reanalyzes become imperative for acquiring crucial information. This information can support water resource management actions and their impacts on both natural and productive ecosystems.
To analyze the precipitation patterns, we utilized the CHIRPS product’s precipitation time series for five ecoregions within the Guanacaste Conservation Area, located in the northwestern Pacific region of Costa Rica. These curves were strongly and negatively correlated with time series from sea surface temperature monitoring regions, including Niño 1.2, Niño 3, Niño 3.4, and Niño 4.
All analyzed ecoregions exhibited strong negative correlations with the Niño 1.2 region, with correlation coefficients (R values) ranging between -0.72 to -0.74. Additionally, a lag of four to five months was observed in the Niño 4 curve compared to the Niño 1.2 region. This study suggests that the Niño 4 anomaly, with a lag of approximately 4 to 5 months, can serve as an indicator of possible impacts on precipitation patterns in different ecoregions. This provides sufficient time to plan actions, particularly within the agricultural sector. This study demonstrates the potential predictability of the effects of ENSO phenomenon on precipitation patterns for large areas with a certain eco-systemic homogeneity, such as the ecoregions in the Guanacaste Conservation Area.
La kalokagathia in Senofonte: un’eccellenza eminentemente socratica
Authors: Stavru Alessandro 
Published: February 2024

Kalokagathiais a core concept of Greek culture, which is usually associated with the professional excellence of an individual in a given field of activity or work. It acquires a markedly moral and aesthetic value thanks to Xenophon, for whom it is neither an innate nor an acquired virtue, but the ability to achieve virtue through consistent moral training. It is for Xenophon a specifically Socratic virtue, as the number and significance of occurrences of kalokagathiain his Socratic works (compared to the non-Socratic works) clearly shows. Here the term has eight different meanings–whereby thekaloikagathoiare strictu sensuonly the Socratics, i.e. the group of companions who gather around the kaloskagathospar excellence Socrates (Mem. 1.2.48). Kalokagathiais linked to self-control (enkrateia), thus entailing freedom from exterior values (Mem.1.5.1). Xenophon’s Socrates is not kaloskagathosbecause he is excellent in doing or knowing something, but because he aims at making his interlocutors “better” (beltion) through philosophical intercourse, thus leading them to akalokagathiawhich departs from traditional “excellence” (Mem. 2.1.1-7). Hence the friendship and the political benefits that derive from Socrates’s kalokagathia: being a kaloskagathosentails establishing relationships grounded on reciprocity, which are all aimed at the well-being of the city (Mem. 2.6.14-29). In my paper, I explore these facets of kalokagathia, focusing on the connections with other ethical concepts that are important for Xenophon (esp. enkrateia,autarkeiaandphilia).