bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enfermedad pulmonar por Mycobacterium intracellulare, un reto diagnóstico. Reporte de caso
Authors: Zamora Becerra Leidy Vanesa , Moreno Carrillo María Angélica , Ramírez Luis Eduardo 
Published: December 2023

La incidencia de infección por micobacterias no tuberculosas (MNT) y el número de casos han ido en aumento, especialmente en mujeres y personas mayores, teniendo en los Estados Unidos entre el 2008 y 2015 una incidencia de 4.16 a 6.69 por 100000 entre las mujeres y de 12.70 a 18.37 por 100000, entre los mayores de 65 años (1). “Los pacientes con compromiso estructural del parénquima pulmonar, antecedente de inmunosupresión o inmunodeficiencia tienen mayor riesgo de desarrollar infección por MNT”. Sin embargo, se han presentado informes de pacientes inmunocompetentes en asociación con opacidades nodulares y bronquiectasias (2).
Se trata de una mujer de 79 años con antecedente de tuberculosis pulmonar documentada en dos oportunidades: último proceso infeccioso en el año 2021. Recibió manejo por seis meses de esquema vigente con tetraconjugado. Actualmente acude a consulta con cuadro clínico de más de seis meses de evolución dados por pérdida de peso de más del 10 % en un año, disnea a moderados esfuerzos y tos con expectoración purulenta. Al examen físico se encontró índice de masa corporal (IMC) bajo, tórax hipoexpansible con estertores tipo crépitos en ambos hemitórax. En la tomografía de tórax se evidenciaron bronquiectasias generalizadas, algunas áreas de árbol en gemación y lesiones cavitadas. Se consideró la realización de fibrobroncoscopia con lavado broncoalveolar documentándose baciloscopias negativas, con cultivo positivo para micobacteria no tuberculosa. Se solicitó tipificación de micobacterias con coloración de Kinyoun, y pruebas bioquímicas a partir de cepas de cultivo del lavado broncoalveolar, con reporte positivo para Mycobacterium intracellulare. Se inició por lo tanto manejo con azitromicina 500 mg, rifampicina 600 mg y etambutol 975 mg diarios. Los profesionales sanitarios deben ser conscientes de la posible infección por MNT sobre todo existiendo afectación estructural pulmonar previa, basando el tratamiento en la sospecha clínica y/o las circunstancias epidemiológicas.
Conferencia Jorge Restrepo Molina presentada en el Congreso Colombiano de Neumología 2023
Authors: Quintero Barrios Jorge Luis 
Published: December 2023

Es un honor dar la charla Restrepo Molina en este el vigésimo congreso de nuestra sociedad. Quiero agradecer primero que nada la confianza puesta en mi por el presidente del congreso. La conferencia Restrepo Molina fue dada por primera vez en 1995, por mi profesor, así como por el maestro de mis profesores el doctor Darío Maldonado, y desde ese año esta conferencia acompaña nuestro congreso. El listado de colegas, amigos y de varios de mis docentes que han tenido este honor a través de estos años hace realmente que esta responsabilidad sea aún mayor. [Charla realizada en el Congreso Colombiano de Neumología 2023]
Problems Faced by Cancer Patients due to COVID 19 at Tertiary Cancer Hospital, Chitwan, Nepal
Authors: Sushila Koirala  , Sabina Giri  
Published: December 2023

Background: The corona virus disease (COVID 19) Pandemic has had a global impact on health care. Patients with cancer have been affected by the COVID 19 Pandemic and faced various psychosocial problems.
Materials and Methods: A descriptive cross-sectional study on title “Problems Faced by Cancer Patients due to COVID 19 at Tertiary Cancer Hospital, Chitwan, Nepal” was conducted at B.P. Koirala Memorial Cancer Hospital, Chitwan to assess problems faced by cancer patients. Non- probability purposive sampling technique was used to select the sample and sample size was 50. Data was collected by using structured interview schedule and distress thermometer.
Findings: In this research 50 respondents were included for the study. Among them 72% respondents faced treatment related problems where 27.7% respondents faced unavailability of chemo medicine, nearly half of respondents (48%) faced the transportation related problems and unavailability of transportation service was the key transportation problems faced by 58.3% respondents. Similarly, nearly half of the (46%) faced the accommodation problems and more than two fifth (42%) had economic related problems during COVID 19 pandemic situation.
Conclusion: Cancer patients have faced several problems during COVID 19 pandemic such as unavailability of chemo medicine, treatment delay, lack of transportation services, accommodation problem, financial problems and psychological distress. So, cancer hospital should make strategic planning of health care services by means of alternative solutions like telemedicine, home-based palliative care services, and ensuring the availability of essential cancer drugs.
Finding significant pathogens in blood cultures in children: Should we set the timer to 36 hours?
Authors: Yeung Eugene , Sant Nadia , Sucha Ewa , Belaghi Reza , Le Saux Nicole 
Published: December 2023

Background: Knowledge of time to positivity (TTP) for blood cultures is useful to assess timing of discontinuation of empiric antimicrobials for suspected bacteremia with no focus. Methods: An audit of positive blood cultures from the Children’s Hospital of Eastern Ontario (CHEO) from November 1, 2019, to October 31, 2020, was performed to determine TTP, defined as the start of incubation to a positive signal from automated incubators. Results: Three hundred seventy-six positive blood cultures were identified from 248 patients (average age: 6.27 [SD 6.24] years). Of these, 247 isolates were speciated; 90 (36.4%) were definitive/probable (DP) pathogens (median TTP 12.75 hours) and 157 (63.6%) possible/probable (PP) contaminants (median TTP 24.08 hours). At each time point, the adjusted rate of positive blood culture was significantly higher for DP pathogens compared to PP contaminants (hazard ratio [HR] 1.80 [95% CI 1.37, 2.36]) and for children ≤27 days old compared to the oldest age group (HR 1.94 [95% CI 1.19, 3.17]). By 36 hours, the proportion of positive cultures was significantly higher in the youngest age group (≤27 days) compared with the 3–11 years old age group (91.7% [95% CI 68.6%, 97.8%] versus 58.2% [95% CI 46.91%, 68.06%]). Conclusion: Across all ages, the TTP was significantly shorter for blood cultures with DP pathogens compared to those with PP contaminants (HR 1.80 [95% CI 1.37, 2.36]). In newborns, 90% of blood cultures were positive by 36 hours supporting this re-assessment time for empiric antimicrobials. TTP was longer in children ≥12 months, possibly related to other factors such as blood culture volume.
ЕКСПЕРИМЕНТАЛЬНІ ДОСЛІДЖЕННЯ ВПЛИВУ ВМІСТУ ГУМОВОЇ КРИХТИ НА ВЛАСТИВОСТІ АСФАЛЬТОБЕТОННИХ СУМІШЕЙ
Authors: Шимчук О.П., , Процюк В.О., , Талах Л.О., 
Published: December 2023

У статті наведено результати експериментальних досліджень впливу гумової крихти, використаної в якості модифікатора на структуру і властивості бітумів, та, відповідно, асфальтобетонної суміші, що забезпечить покращення фізико-механічних характеристик таких матеріалів.
Pengaruh Promosi dan Variasi Produk Terhadap Minat Beli Konsumen Pada Kopi Sungguh Pasar Modern Intermoda Cisauk
Authors: Buulolo Betisama , Akbar Mada Faisal 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh promosi dan variasi produk baik secara parsial maupun secara simultan terhadap minat beli konsumen pada kopi Sungguh Pasar Modern Intermoda Cisauk, metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif yang bersifat asosiatif. Berdasarkan hasil uji regresi linear berganda diperoleh Y = 1,818 + 0,764x1 + 0,290x2 + e, yang artinya nilai konstanta sebesar 1,818 nilai ini menunjukkan bahwa saat promosi dan variasi produk bernilai (0) atau tidak meningkat minat beli konsumen (Y) akan bernilai 1,818 dan kedua variabel memiliki pengaruh positif. Nilai koefisien determinasi sebesar sebesar 0,903 artinya promosi (x1) dan variasi produk (x2) berpengaruh terhadap minat beli konsumen sebesar 90%, nilai korelasi untuk promosi 0,950 dengan signifikan (0,000 < 0,025) dan nilai korelasi variasi produk 0,889 dengan signifikan (0,000 < 0,025). Uji hipotesis diperoleh F hitung > f tabel (485.657 > 3.10) dengan nilai sig (0,000 < 0,05) maka Ho ditolak Ha diterima artinya terdapat pengaruh yang signifikan secara simultan antara promosi (X1) dan Variasi produk (X2) Terhadap minat beli konsumen (Y) pada kopi Sungguh Pasar Modern Intermoda Cisauk.
Faktor Faktor yang Mempengaruhi Profitabilitas Pada Perusahaan Food And Beverage Di BEI
Authors: Mahendra Dimas Ramdhan , Widodo Agustina 
Published: December 2023

abstract
This study aims to prove the effect of working capital turnover, cash turnover and liquidity on profitability in food and beverage companies listed on the Indonesia Stock Exchange. This study uses the dependent variable profitability, while the independent variables are working capital turnover, cash turnover and liquidity. Data collection techniques in this study used the documentation method with the sampling method, namely the purposive sampling method. The research sample consisted of 18 companies with 36 observations. The data analysis technique used was multiple linear regression analysis. Based on the results of the study, working capital turnover and cash turnover had no significant positive effect on profitability in food and beverage companies, while liquidity had a significant positive effect on profitability in food and beverage companies. The coefficient of determination (adjusted R2) is 0.083. This means that the independent variables, namely working capital turnover, cash turnover and liquidity in this regression model are able to explain the dependent variable profitability 11.6% while 91.7% is explained by other variables not examined in this research model.
THE IMPORTANCE OF BRAND AWARENESS AS A MARKETING STRATEGY FOR BUSINESS SUSTAINABILITY
Authors: UTAMA Andyan Pradipta , SIHALOHO Sandro , NABILA Suci Novia 
Published: December 2023

The implementation of Community Service aims to open the insight of small entrepreneurs about the importance of consumers being aware of the existence or existence of brands sold by marketers. In the midst of economic recovery conditions after the Covid-19 pandemic and supported by the ease of digital marketing, many new entrepreneurs have emerged. The number of new entrepreneurs who compete fiercely with existing entrepreneurs plus the declining purchasing power of the community makes people more selective in buying a product. There is a tendency for consumers to choose products that are well known both through product experience and based on information obtained through various sources. Consumers are more likely to be loyal by buying products from well-known brands because they feel more comfortable and perceive familiar brands as more reliable, available, easier to find, and unquestionably quality. This training is designed to make people aware as business people that consumers will not look at a company's brand if it is considered bad and has a bad reputation in the market so that a really mature strategy is needed so that the brand can be known by many people. Consumer awareness of a brand is expected to increase satisfaction and increase consumer loyalty. Overall, participants are expected to understand the importance of brand awareness concepts and strategies, but have not been able to practice them in real and detail. Continuous participation is needed in providing training until participants are able to practice it.
Pelatihan Jaringan Komputer Menggunakan Cisco Packet Tracer di SMK Ar Rahmah Bantul
Authors: Hardiani Tikaridha , Esi Putri Silmina  , Danur Wijayanto  
Published: December 2023

SMK Ar-Rahmah berdiri pada tanggal 24 Oktober 2011. Sekolah berlokasi di komplek Pondok Pesantren Ar-Rahmah. SMK ini di bawah naungan Yayasan Bani Fakhruddin yang berlokasi di Kedungbule, Trimurti, Srandakan, Bantul, Provinsi Daerah Istimewa Yogyakarta. SMK Ar-Rahmah hanya memiliki penjurusan Teknik Komputer dan Jaringan. Untuk meningkatkan kemampuan lulusan, diperlukan pendalaman pengetahuan dan keterampilan mengenai Jaringan Komputer. Oleh sebab itu perlu diadakannya pelatihan jaringan komputer dengan memberikan penjelasan dasar-dasar Jaringan Komputer dan simulasinya menggunakan Aplikasi Cisco Packet Tracer. Pelatihan dilakukan dengan memberikan persoalan Jaringan seperti di dunia nyata yang kemudian disimulasikan dengan menggunakan Cisco Packet Tracer , sehingga dapat lebih memberikan gambaran dan meningkatkan kemampuan serta keterampilan siswa dalam bidang Jaringan Komputer. Peserta sangat antusias dengan materi yang diberikan dikarenakan sesuai dengan penjurusan dan hasil evaluasi menunjukkan 75% peserta puas dengan pelatihan yang diberikan karena peserta mendapat wawasan lain selain pelajaran dari sekolah.
Usulan Desain Sasis Sepeda Motor Listrik Menggunakan Pendekatan Data Antropometri
Authors: Ardana Hudha Dwi , Juhara Sutresna , Rahayu Monita 
Published: December 2023

Kendaraan berbahan bakar listrik terus berkembang, khususnya sepeda motor listrik yang banyak mendapatkan perhatian dari pemerintah, seperti data yang diperkirakan MENHUB akan kebutuhan kendaraan listrik hingga tahun 2030 mencapai 132.000 unit. Sasis menjadi salah satu bagian terpenting pada sepeda motor, adanya pembuatan sepeda motor yang terus meningkat akan tetapi banyak yang kurang memperhatikan kenyamanan pada pembuatannya. PEI (Perhimpunan Ergonomi Indonesia) menjadi tempat pengambilan data yang kemudian di olah dengan percentile untuk mendapatkan ukuran yang sesuai kebutuhan masyarakat, hasil perhitungan yang diusulkan dari hasil yang diinginkan pengguna dan memiliki kriteria ergonomi dimana 50 cm untuk ukuran tinggi dari tempat duduk ke alas kaki, 67 cm ukuran tempat duduk ke lantai, 41 cm untuk jarak tempat duduk ke kemudi, 29 cm untuk panjang alas kaki, 25 cm lebar tempat duduk, 70 cm panjang total kemudi, dan 14 cm untuk lebar genggam kemudi. Hasil dari perhitungan dan desain yang dibuat diminta tanggapan dari pengguna yang mana 26,7% menyatakan cukup bagus 26,7%, inovatif 26,7%, menarik 33,3%, dan nyaman 13,3%.
Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis
Authors: Zhang Ruizhe , Xie Qingya , Xiao Pingxi 
Published: December 2023

AimsThis meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G&gt;A), rs5882 (G&gt;A), rs1800775 (C&gt;A), rs4783961 (G&gt;A), rs247616 (C&gt;T), rs5883 (C&gt;T), rs1800776 (C&gt;A), and rs1532624 (C&gt;A) with coronary artery disease (CAD) and the related underlying mechanisms.MethodsA comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between CETP gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of CETP gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. P &lt; 0.05 was considered statistically significant.ResultsA total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the CETP rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR = 0.846, P &lt; 0.001), the dominant model (OR = 0.838, P &lt; 0.001) and the recessive model (OR = 0.758, P &lt; 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all P &lt; 0.05). The CETP rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model (P = 0.802, P = 0.392), the dominant model (P = 0.556, P = 0.183) and the recessive model (P = 0.429, P = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.ConclusionsThe CETP rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The CETP rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865.
Incidence density of hyperuricemia and association between metabolism-related predisposing risk factors and serum urate in Chinese adults: a cohort study
Authors: Liang Hailun , Zhang Jijuan , Yu Hancheng , Ding Lijie , Liu Feng , Wang Jun 
Published: December 2023

BackgroundEvidence regarding the association between metabolism-related indicators and serum urate (SU) is limited. We aimed to obtain the incidence density of hyperuricemia and to explore the association between metabolism-related predisposing risk factors and SU.MethodsA total of 48,979 Chinese adults from the Beijing Physical Examination Center were included in the study. The partial least squares path model was used to explore the relationship between SU and metabolism-related risk factors. The generalized additive model was used for smooth curve fitting, showing the sex-specific associations of SU at follow-up with baseline fasting blood glucose (FBG) concentrations and age.ResultsThe incidence density of hyperuricemia was 78/1000 person-years. Baseline SU, age, sex, obesity, FBG, and lipid metabolism were significantly associated with SU at follow-up (all P values &lt;0.05). Non-linear relationships were found between the baseline FBG concentrations and SU at follow-up, while U-shaped associations were observed between baseline age and SU at follow-up.ConclusionsThe SU concentration is associated with several metabolism-related risk factors such as obesity and FBG. Recognition of these associations will aid in a deeper understanding of the multifaceted nature of SU regulation.
Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC gene
Authors: Doğan Durmus , Özcan Eda Gül , Çakır Dilek Ülker , Sılan Fatma 
Published: December 2023

IntroductionVitamin D binding protein (VDBP) plays a crucial role in vitamin D transport and metabolism. The rs4588-A polymorphism of the GC gene, encoding VDBP, has been associated with altered serum VDBP and 25-hydroxyvitamin D (25OHD) levels. However, the mechanisms underlying these effects remain unclear. We aimed to investigate the relationship between urinary VDBP excretion and serum VDBP and 25OHD levels in individuals with and without the rs4588-A allele.MethodsA cross-sectional study was conducted on 109 children (mean age: 11.96 years) to explore the impact of rs4588-A on vitamin D metabolism and urinary VDBP excretion. Biochemical analyses determined serum 25OHD and VDBP levels, and urinary VDBP-to-creatinine ratio (u-VDBP/Cr). Genotyping for rs4588 SNP was performed using LightSNiP assay. Statistical analyses included correlation, linear regression, and comparison between allele groups.ResultsParticipants carrying the rs4588-A allele exhibited lower serum 25OHD levels compared to non-carriers (median (IQR): 11.85 (3.5) vs. 12.86 (4.9), p = 0.023). However, no statistically significant differences were observed in serum VDBP levels (126.34 ± 59.3 in rs4588-A vs. 136.49 ± 51.3 in non-rs4588-A, p = 0.141) or in u-VDBP/Cr (median (IQR): 0.4 (0.35) in rs4588-A vs. 0.386 (0.43) in non-rs4588-A, p = 0.189) between the two allele groups. A significant inverse correlation between u-VDBP/Cr and serum VDBP levels was found only in rs4588-A carriers (r = -0.367, p = 0.024). No such correlation was observed in non-carriers or the entire cohort. A linear regression analysis confirmed the impact of u-VDBP/Cr on serum VDBP levels in rs4588-A carriers (B = -0.269, t = -2.185, p = 0.035).ConclusionIndividuals with the rs4588-A allele in the GC gene had lower serum 25OHD levels. An inverse correlation between urinary VDBP excretion and serum VDBP levels was observed, suggesting a partial role of the renal pathway in altered serum VDBP and 25OHD levels linked to the rs4588-A allele.
A study on the recognition of monkeypox infection based on deep convolutional neural networks
Authors: Chen Junkang , Han Junying 
Published: December 2023

IntroductionThe World Health Organization (WHO) has assessed the global public risk of monkeypox as moderate, and 71 WHO member countries have reported more than 14,000 cases of monkeypox infection. At present, the identification of clinical symptoms of monkeypox mainly depends on traditional medical means, which has the problems of low detection efficiency and high detection cost. The deep learning algorithm is excellent in image recognition and can extract and recognize image features quickly and reliably.MethodsTherefore, this paper proposes a residual convolutional neural network based on the λ function and contextual transformer (LaCTResNet) for the image recognition of monkeypox cases.ResultsThe average recognition accuracy of the neural network model is 91.85%, which is 15.82% higher than that of the baseline model ResNet50 and better than the classical convolutional neural networks models such as AlexNet, VGG16, Inception-V3, and EfficientNet-B5.DiscussionThis method realizes high-precision identification of skin symptoms of the monkeypox virus to provide a fast and reliable auxiliary diagnosis method for monkeypox cases for front-line medical staff.
Epstein-Barr virus infection as potential indicator of the occurrence and clinical presentation of systemic lupus erythematosus
Authors: Banko Ana , Cirkovic Andja , Miskovic Rada , Jeremic Ivica , Grk Milka , Basaric Milica , Lazarevic Ivana , Raskovic Sanvila , Despotovic Aleksa , Miljanovic Danijela 
Published: December 2023

IntroductionThe relationship between Systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection has been suggested for decades, but the underlying mechanism of the EBV influence on SLE development remains to be elucidated.MethodsThe goals of this research, which included 103 SLE patients and 99 controls, were to investigate the association of the parameters of EBV infection and SLE, to explore whether pooled demographic, clinical and EBV markers achieve a more significant effect on SLE development than each of them individually, and to evaluate EBV nuclear antigen 1 (EBNA1) and latent membrane protein 1 (LMP1) gene polymorphisms in isolates from SLE patients.ResultsComprehensive results related to serological, molecular and sequence markers of EBV infection in SLE patients demonstrated even 24 times higher possibility of having SLE if there is the presence of anti-EBV-EA(D) (early antigen) IgG antibodies (OR=24.086 95%CI OR=2.86-216.07, p=0.004). There was the same distribution of glucocorticoids (p=0.130), antimalarials (p=0.213), and immunosuppressives (p=0.712) in anti-EBV-EA(D) IgG positive and negative SLE patients. Further, higher anti-EBV-EA(D) IgG antibodies titers were identified as independent factors associated with lymphopenia, hematological SLE manifestation (OR=1.041, 95%CI OR=1.01-1.08, p=0.025, while a higher titer of anti-CA (viral capsid antigen) IgG antibodies (OR=1.015, 95%CI OR=1.01-1.03, p=0.019) and positive RF (rheumatoid factors) (OR=4.871, 95%CI OR=1.52-15.61, p=0.008) were identified as independent factors associated with alopecia within SLE. Finally, novel data on EBV EBNA1 and LMP1 gene polymorphisms in lupus are reported.ConclusionThe results support further investigation targeting EBV as a prognostic marker and therapeutic goal for lupus.