bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passiflora fieldiana Tillett ex Vanderplank, a new species in subgenus Passiflora supersection Laurifolia from Venezuela: Passifloraceae
Authors: Vanderplank John , Adair Andrew 
Published: October 2023

SummaryPassiflora fieldiana Tillett ex Vanderplank, a most spectacular passion flower, is fully described for the first time. Its history, distribution and cultivation are discussed.
The role of generative design and additive manufacturing capabilities in developing human–AI symbiosis: Evidence from multiple case studies
Authors: Bendoly Elliot , Chandrasekaran Aravind , Lima Mateus do Rego Ferreira , Handfield Robert , Khajavi Siavash H. , Roscoe Samuel 
Published: October 2023

AbstractThe benefits of additive manufacturing (AM) extend beyond the attributes of physical products and production processes they enable. Experience with AM can augment the way design is approached and can increase opportunities to pivot toward less familiar design tasks. We begin this qualitative study with a natural experiment made possible by an exogenous shock: the COVID‐19 pandemic. Through a three‐stage case study approach using a grounded theory‐building method, we contrast AM usage among a set of firms, half of which pivoted their resources away from their traditional production and toward a response to this shock. We engage in an abductive reasoning approach to consider common threads in AM capabilities that facilitated this pivoting. Our analyses suggest that the advanced use of generative design (GD), a category of computational technologies enabling novel and optimized design, is a critical attribute of these firms that ended up pivoting to make COVID‐related products. Specifically, firms with experience applying this capability demonstrated a unique ability to pivot during this shock and emphasized their valuation of AM‐enabled agility. We revisited these firms 2 years after initial contact and found that GD was associated with higher levels of innovation and was largely viewed by designers as a mechanism driving double‐loop learning. Overall, our study provides insights into the symbiosis between human and artificially intelligent GD, and the role of such symbiosis in advancing AM capabilities.
How mobile is the transnational business elite? Evidence from Swiss banking executives
Authors: Araujo Pedro , Davoine Eric 
Published: October 2023

AbstractOver the last two decades, a growing literature has examined the emergence of a transnational business elite. However, the pathways of transnational mobility have not been fully characterized. In this article, we use a combination of sequence analysis and the concept of a career script to investigate the geographical mapping and organizational contexts in which transnational mobility occurs. To achieve this, we rely on a database of 186 executives from the 28 largest Swiss banks, as well as 20 interviews with chief human resource officers and 15 interviews with banking executives. Our findings contribute to relativize and differentiate the phenomenon of transnationalization of business elites by underlining the importance of the career context and by identifying distinct interpretations of international career resources according to different types of banks.
Effects of entecavir and tenofovir alafenamide fumarate treatment on renal function in Japanese elderly patients with chronic hepatitis B
Authors: Tanaka Misako , Akahane Takemi , Kawaratani Hideto , Yorioka Nobuyuki , Koizumi Aritoshi , Asada Shohei , Matsuda Takuya , Iwai Satoshi , Tsuji Yuki , Fujinaga Yukihisa , Nishimura Norihisa , Kitagawa Koh , Kaji Kosuke , Namisaki Tadashi , Yoshiji Hitoshi 
Published: October 2023

AbstractAimEntecavir (ETV) and tenofovir alafenamide fumarate (TAF) are considered safe nucleoside/nucleotide analogs (NA) for the kidney. This study aimed to investigate the long‐term effects of ETV or TAF on renal function in elderly patients with chronic hepatitis B (CHB) in Japan.MethodsThe study included 246 CHB patients treated with ETV (184 patients) or TAF (62 patients) for at least 2 years. These patients were divided into two groups: those <65 years of age (130 patients) and those ≥65 years of age (116 patients). The effects of the NAs on renal functions were examined by comparing the estimated glomerular filtration rates (eGFR) from baseline to 2 years between the two groups.ResultsThe change in eGFR from baseline to 1 or 2 years after treatment was significantly decreased in both groups. However, the amount of change at 1 and 2 years was significantly greater in the group aged ≥65 years than in the group aged <65 years. The amount of change in eGFR from baseline to 1 and 2 years after treatment was significantly greater in the group aged ≥65 years than in the group aged <65 years, regardless of the type of NA, the prior treatment history, cirrhosis/chronic hepatitis, hypertension, dyslipidemia, and diabetes. Additionally, logistic regression analysis showed that age ≥65 years was independently associated with a decreased eGFR after 2 years of NA treatment.ConclusionsLong‐term administration of NA to CHB patients over 65 years of age should be carefully monitored for renal impairment.
Fabrication of healthier monoglyceride‐based oleogel containing linseed‐sunflower oil and its application as shortening in cake formulation
Authors: Roufegarinejad Leila , Ahmadi Golnar , İcyer Necattin Cihat , Saıd Toker Omer , Habibzadeh Khiabani Arezou 
Published: October 2023

SummaryThe aim of this work was to fabricate monoglyceride oleogels with combination of linseed (LO) and sunflower oil (SO) and evaluate their effect in baked cakes as a shortening replacer. Physicochemical properties of the oleogels were evaluated from FTIR, Differential scanning calorimetry (DSC), X‐ray diffraction (XRD), morphologic, oil binding, oxidative stability, and fatty acid point of view. Results showed that as the content of linseed oil increases, the ratio of omega‐6 to omega‐3 fatty acids in oleogels decreases. Adding 50% of each oil in the oleogel formulation improved crystallinity, morphological, and intermolecular hydrogen bonding. The 50% SO‐50% LO sample exhibited the highest oil‐binding capacity (89.83 ± 3.51) and peroxide value (1.46 ± 0.26) and was utilised in cake formulations as an optimised sample. Fatty acid, specific volume, porosity, peroxide value, colour, and sensory properties of cakes oleogel were also analysed. The formulated cake with oleogels showed an acceptable peroxide and fatty acid composition. As a result, using oil combinations in oleogel and cake formulations could pave the way for developing foods with a balance ω6/ω3 ratio and reduced levels of saturated and trans fatty acids.
The Effect of Glycolic Acid on Cultured Human Skin Fibroblasts: Cell Proliferative Effect and Increased Collagen Synthesis
Authors: Kim Seong‐Jin , Won Young‐Ho 
Published: October 2023

AbstractGlycolic acid peeling is known to improve photoaging processes such as wrinkling and roughness, but this effect has not been clearly defined, even though functional activation of fibroblasts has been suggested. The study was aimed to determine the effects of glycolic acid and malic acid (AHA: alpha hydroxy acid) on cultured dermal fibroblasts. Whether it directly increases cell proliferation may be an important factor influencing the production of extracellular matrix such as type I collagen.Cultured human skin fibroblasts were treated for 24 hours with glycolic acid and malic acid at different concentrations (10−4, 10−5, 10−6 M), and cell proliferation was measured by MTT assay. Then quantitative analysis of collagen synthesis was performed by PICP (Procollagen Type I C‐peptide) enzyme immunoassay and radioisotope (3H‐proline) labelled collagen assay.The results showed increased cell proliferation and collagen production in response to glycolic acid in a dose dependent manner. The range of cell proliferation and collagen production were significantly higher with glycolic acid treatment than with malic acid or control. It was suggested that the favorable effects of glycolic acid treatment on aging skin were mediated by increased cell proliferation in addition to functional activation of fibroblasts.
Pemphigus Vulgaris Associated with Transient Acanthosis Nigricans Like Lesion
Authors: Usui Keitaro , Kondo Aki , Nakagawa Hidemi 
Published: October 2023

AbstractA patient with pemphigus vulgaris was treated with predonisolone and cyclosporin. At the sites of healing erosions, hyperkeratotic, hyperpigmented plaques developed; they were clinically and histologically similar to acanthosis nigricans. These lesions regressed after a few months. This case and others described in the literature suggest that such dermatoses might be caused by immunologically as well as mechanically mediated epidermal injury.
Changes in Immunological Parameters after Combination Adjuvant Therapy with Intravenous DTIC, ACNU, and VCR, and Local Injection of IFN‐β (DAV + IFN‐β Therapy) into Malignant Melanoma
Authors: Umeda Tadashi , Aoki Kazuhiro , Yokoyama Akiko , Ohara Hiroyuki , Hayashi Ohmi , Tanaka Kazuyuki , Nishioka Kiyoshi 
Published: October 2023

AbstractCombination adjuvant therapy with intravenous dimethyl triazeno imidazole carboxamide (DTIC), 1‐[4‐amino‐2‐methyl‐5‐pyrimidinyl]‐methyl‐3‐[2‐chloroethyl]‐3‐nitrosourea hydrochloride (ACNU) and vincristine (VCR) and local injection of interferon‐β (IFN‐β) (DAV + IFN‐β therapy) has been widely applied to treat malignant melanoma, and its therapeutic effect is accepted in Japan. Natural killer (NK) activity, CD4+ and CD8+ T cell counts, CD4/CD8 ratio, and white blood cell counts were analyzed before and after DAV + IFN‐β therapy in order to validate its efficacy. After DAV + IFN‐β therapy, the CD4/CD8 ratio was elevated; however, numbers of both CD4+ and CD8+ T cells and NK activity were consecutively depressed. Peripheral lymphocytes were also decreased, possibly by myelosuppression due to the DAV therapy. The posttreatment suppression of NK activity appeared in spite of the administration of IFN‐β. It is suggested that a more effective adjuvant immunomodulator should be introduced to improve the therapeutic effect of the combination adjuvant chemotherapy in malignant melanoma.
A Case of Nodular Cystic Fat Necrosis: The End Stage Lesion Showing Calcification and Lipomembranous Changes
Authors: Oh Chee‐Won , Kim Kab‐Hyeong 
Published: October 2023

AbstractNodular cystic fat necrosis, first described by Przyjemski et al. in 1978, is a distinct, benign subcutaneous lesion characterized histologically by encapsulated fat necrosis. We report a case of nodular cystic fat necrosis in a 22‐year‐old man who had had two mobile, rice‐sized, deep‐seated papules on his right shin for ten years after trauma. Histologically, the excised mass showed encapsulated fat necrosis, calcification, and lipomembranous changes. The encapsulation of necrotic tissue may prevent further extension of adiponecrosis. The subcutaneous fat is prone to trauma or ischemia. The observation of lipomembranous changes in nodular cystic fat necrosis seems to support the concept that lipomembranous change is a nonspecific pattern of the fat necrosis due to multiple local or systemic events causing a compromise in the blood supply of the subcutaneous tissue.
Expression and equilibrium denaturation of cardiac troponin I: stabilization of a folding intermediate during denaturation by urea
Authors: Morjana Nihmat , Tal Rony 
Published: October 2023

Human cardiac troponin I has been expressed at high level in Escherichia coli as a fusion protein by using the expression vector Ptac114. The expressed protein forms primarily intracellular inclusion bodies that are solubilized in the presence of 8 M urea. The purified troponin I is recognized by anti‐(human cardiac troponin I) monoclonal antibodies. Equilibrium denaturation of recombinant human troponin I and bovine troponin I is compared by monitoring changes in the protein's fluorescence and CD characteristics. At pH 7·5 the equilibrium denaturation of both proteins by urea occurs in two distinct steps involving at least three major conformational states: native, intermediate and fully denatured. The biphasic profile in the presence of urea is observed by both fluorescence and CD spectroscopy. In the intermediate state the native tertiary structure is largely disrupted and 40% of the secondary structure is conserved, as suggested by near‐UV and far‐UV CD respectively. Thermal denaturation of troponin I, as followed by fluorescence, shows a loss in the signal that is not reversible after heating to 90 °C. In the presence of a constant amount of urea (not greater than 0·5 M) the thermal denaturation becomes biphasic, suggesting the accumulation of an intermediate species that is stabilized by urea. The fluorescence of 1‐anilino‐8‐ naphthalenesulphonate produced on binding troponin I decreases in the presence of increasing concentrations of urea up to 3 M; at higher urea concentrations no further change in the remaining signal is observed. Kinetic studies show at least two phases of renaturation for troponin I previously denatured with 8 M urea, whereas only a single phase is detected for the renaturation process in the presence of 3 M urea. The results suggest the occurrence of a stable folding intermediate, the formation of which might be related to the two‐domain architecture of troponin I.
Roles of nurse‐surgeons in global surgical care: A scoping review
Authors: Grota Tenber , Betihavas Vasiliki , Burston Adam , Jacob Elisabeth 
Published: October 2023

AbstractAimTo identify the roles of nurse‐surgeons in the provision of surgical care.DesignScoping review.MethodsThis scoping review adhered to the JBI guideline for scoping reviews and EQUATOR Network's PRISMA‐ScR checklist. Searches were performed from May 2022 to July 2022 using a combination of MeSH headings, keywords and filters via database and hand searching based on the eligibility criteria. Keywords included nurse‐surgeon, nurse endoscopist, nurse hysteroscopist and nurse cystoscopist. Data sources were CINAHL, Cochrane, Google Scholar, PubMed and Scopus. Descriptive analysis was used to report the findings.ResultsNinety‐six included records indicated nurse‐surgeon practice in 26 countries. Forty‐one nurse‐surgeon titles were found, the majority of which were types of nurse practitioner. A total of 5,684,198 surgeries were performed by nurse‐surgeons varying from laparotomies to biopsies. Nine records reported that nurse‐surgeons perform surgeries safely and on par with physicians with zero to minimal complications. Nineteen records reported improved surgical care efficiency by nurse‐surgeons in terms of patient access to surgery, waiting times, surgery times, patient show rates, patient education, physician workload and junior physicians' training. Seven records reported high patient satisfaction. Nurse‐surgeons were cost‐effective according to five records. Thirteen records recommended the standardization of nurse‐surgeon practice.ConclusionNurse‐surgeons performed millions of surgeries worldwide assisting in easing the global surgical burden. This review identified the roles and benefits nurse‐surgeons play in global surgical care. Research gaps on nurse‐surgeon roles were discovered including the ambiguity in nurse‐surgeon titles and the need to regulate nurse‐surgeon practice.ImpactThis research addressed the clinical safety, quality, contribution to timely surgical access and cost efficiency of nurse‐surgeon performed surgeries, as well as the need to standardize nurse‐surgeon practice and use a more consistent nurse‐surgeon title to ensure role identification and monitoring.
The effects of sex on extinction dynamics of Chlamydomonas reinhardtii depend on the rate of environmental change
Authors: Petkovic Nikola , Colegrave Nick 
Published: October 2023

Abstract
The continued existence of sex, despite many the costs it entails, still lacks an adequate explanation, as previous studies demonstrated that the effects of sex are environment-dependent: sex enhances the rate of adaptation in changing environments, but the benefits level off in benign conditions. To the best of our knowledge, the potential impact of different patterns of environmental change on the magnitude of these benefits received less attention in theoretical studies. In this paper, we begin to explore this issue by examining the effect of the rate of environmental deterioration (negatively correlated with population survival rate), on the benefits of sex. To investigate the interplay of sex and the rate of environmental deterioration, we carried out a long-term selection experiment with a unicellular alga (Chlamydomonas reinhardtii), by manipulating mode of reproduction (asexual, facultative or obligate sexual) and the rate of environmental deterioration (an increase of salt concentration). We monitored both the population size and extinction dynamics. The results revealed that the relative advantage of sex increased at the intermediate rate and plateaued at the highest rate of environmental deterioration. Obligate sexual populations had the slowest extinction rate under the intermediate rate of environmental deterioration, while facultative sexuality was favoured under the high rate-treatment. To the best of our knowledge, our study is the first to demonstrate that the interplay of sex and the rate of environmental deterioration affects the probability of survival, which indicates that mode of reproduction may be an important determinant of survival of the anthropogenic-induced environmental change.
Abstract
The rate of environmental change and mode of reproduction interact. If environment deteriorates at a slow rate, both types of sexual populations will have a similar relative advantage over the asexual populations. At higher rates of environmental deterioration, the relative advantage will shift between the two modes of sexual reproduction: obligate or facultative sexual.
Does the definition of a novel environment affect the ability to detect cryptic genetic variation?
Authors: Riley Camille L. , Oostra Vicencio , Plaistow Stewart J. 
Published: October 2023

Abstract
Anthropogenic change exposes populations to environments that have been rare or entirely absent from their evolutionary past. Such novel environments are hypothesized to release cryptic genetic variation, a hidden store of variance that can fuel evolution. However, support for this hypothesis is mixed. One possible reason is a lack of clarity in what is meant by ‘novel environment’, an umbrella term encompassing conditions with potentially contrasting effects on the exposure or concealment of cryptic variation. Here, we use a meta-analysis approach to investigate changes in the total genetic variance of multivariate traits in ancestral versus novel environments. To determine whether the definition of a novel environment could explain the mixed support for a release of cryptic genetic variation, we compared absolute novel environments, those not represented in a population's evolutionary past, to extreme novel environments, those involving frequency or magnitude changes to environments present in a population's ancestry. Despite sufficient statistical power, we detected no broad-scale pattern of increased genetic variance in novel environments, and finding the type of novel environment did not explain any significant variation in effect sizes. When effect sizes were partitioned by experimental design, we found increased genetic variation in studies based on broad-sense measures of variance, and decreased variation in narrow-sense studies, in support of previous research. Therefore, the source of genetic variance, not the definition of a novel environment, was key to understanding environment-dependant genetic variation, highlighting non-additive genetic variance as an important component of cryptic genetic variation and avenue for future research.
Abstract
In this graphical abstract, a flow chart on the left outlines the criteria used to classify novel environments. On the right, two forest plots are presented: one comparing effect sizes (standardized mean difference in total genetic variance, SDV) between extreme and absolute novel environments, and the other comparing effect sizes between broad-sense and narrow-sense study designs.
Re‐intervention rates and symptom‐free survival at 1 year after endoscopic versus surgical management of strictures in Crohn's disease: A propensity matched analysis of a prospective inflammatory bowel disease cohort
Authors: Pal Partha , Gala Jaini , Rebala Pradeep , Banerjee Rupa , Ramchandani Mohan , Nabi Zaheer , Kanaganti Swathi , Shetty Mahesh G , Gupta Rajesh , Lakhtakia Sundeep , Rao Guduru Venkat , Tandan Manu , Reddy D Nageshwar 
Published: October 2023

AbstractBackground and AimResection for Crohn's disease (CD) related strictures is definitive but carries risk of morbidity, recurrence, and short bowel syndrome. On the contrary, the durability of endotherapy (ET) for CD‐related strictures is questionable. Prospective comparative studies are limited. We aimed to prospectively compare the outcomes of ET in CD strictures with a case‐matched surgical therapy (ST) cohort.MethodsPatients undergoing ET or resection for primary CD strictures (symptomatic, non‐traversable, < 5 cm length, n ≤ 3) between January 2021 and March 2022 in a high‐volume tertiary center were compared with regard to recurrent symptoms, escalation of therapy, re‐intervention, and re‐operation based on propensity matched analysis.ResultsFifty‐nine patients [49% ET, 57.6% male, median (years): 34 (15–74)] had ≥ 12 months of follow up. Before propensity matching, cumulative re‐intervention rate was significantly higher with ET [34.5% (10/29) vs 3.3% (1/30) ST, P = 0.002]. Recurrent symptoms (34.5% vs 26.7%, P = 0.42), escalation of medical therapy (27.5% vs 23.3%, P = 0.64), and re‐operation (7.4% vs 3.1%, P = 0.55) were comparable. In propensity matched analysis adjusted for demographics, disease, and stricture characteristics [n = 42, 21 each, 62% male, median (years): 32 (15–60)], cumulative probability of re‐intervention rates was higher in ET (28.6% vs 4.8%, P = 0.042). The cumulative probability of recurrent symptoms (ET: 33.3% vs surgery 33.3%, P = 0.93), therapy escalation (ET: 23.8% vs surgery 28.6%, P = 0.75), and re‐operation (ET: 9.5% vs surgery 4.8%, P = 0.57) was similar.ConclusionsET for CD strictures require higher re‐interventions compared with resection although re‐operation could be avoided in the majority with comparable symptom free survival at 1 year.
Reply to: “Is oral collagen the elixir of youth?”
Authors: Samadi Aniseh , Ahmad Nasrollahi Saman , Firooz Alireza 
Published: October 2023

AbstractFollowing letter provides answers and explanations for the correspoundance titled “Is oral collagen the elixir of youth.” They have admitted the strengths of our study and also have raised some questions about it, which we aim to provide answers and explanations.