bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of Informed and Affirming Healthcare for Sexual Minority Men: A Call for Patient-Centered Care
Authors: Hascher Kevin , Jaiswal Jessica , LoSchiavo Caleb , Ezell Jerel , Duffalo Danika , Greene Richard E. , Cox Amanda , Burton Wanda M. , Griffin Marybec , John Tejossy , Grin Benjamin , Halkitis Perry N. 
Published: February 2024

Abstract
Background
Sexual minority men (SMM) face severe health inequities alongside negative experiences that drive avoidance of medical care. Understanding how SMM experience healthcare is paramount to improving this population’s health. Patient-centered care, which emphasizes mutual respect and collaboration between patients and providers, may alleviate the disparaging effects of the homophobia that SMM face in healthcare settings.

Objective
To explore how SMM perceive their experiences with healthcare providers and how care can most effectively meet their needs.

Design
Semi-structured qualitative interviews focused on healthcare experiences, pre-exposure prophylaxis (PrEP), and HIV-related beliefs were conducted between July and November 2018.

Participants
The study included a sample of 43 young adult SMM (ages 25–27), representing diverse socioeconomic, racial, and ethnic backgrounds, in New York City.

Approach
Researchers utilized a multiphase, systematic coding method to identify salient themes in the interview transcripts.

Key Results
Analyses revealed three main themes: (1) SMM perceived that their clinicians often lack adequate skills and knowledge required to provide care that considers participants’ identities and behaviors; (2) SMM desired patient-centered care as a way to regain agency and actively participate in making decisions about their health; and (3) SMM felt that patient-centered care was more common with providers who were LGBTQ-affirming, including many who felt that this was especially true for LGBTQ-identified providers.

Conclusions
SMM expressed a clear and strong desire for patient-centered approaches to care, often informed by experiences with healthcare providers who were unable to adequately meet their needs. However, widespread adoption of patient-centered care will require improving education and training for clinicians, with a focus on LGBTQ-specific clinical care and cultural humility. Through centering patients’ preferences and experiences in the construction of care, patient-centered care can reduce health inequities among SMM and empower healthcare utilization in a population burdened by historic and ongoing stigmatization.
Archaeometallurgical Study of a 16th–17th Century “Rapier” Sword Manufactured in Caino (Northern Italy)
Authors: Merico Paolomarco , Faccoli Michela , Gotti Roberto , Cornacchia Giovanna 
Published: February 2024

AbstractA metallurgical study was performed on a 16th–17th century “rapier” sword manufactured in Caino (northern Italy). Metallographic investigations and Vickers microhardness measurements indicate that the rapier was forged by assembling via hammer-welding different hypoeutectoid and near eutectoid steel bars. The rapier blade was heat treated by slack-quenching to increase its hardness, especially near the blade tip, improving the thrusting performance. The chemical composition of slag inclusions was analyzed by scanning electron microscopy coupled with X-ray dispersive spectroscopy. Compositional data of slag inclusions were analyzed by a multivariate statistical strategy aimed to distinguish and classify slag inclusions on the basis of their origin. It was estimated that the temperature reached during the finery and forging processes was at least 1270 °C and 1160 °C, respectively.
Strategies for Identifying Patients for Deprescribing of Blood Pressure Medications in Routine Practice: An Evidence Review
Authors: Sheppard James P. , Benetos Athanase , Bogaerts Jonathan , Gnjidic Danijela , McManus Richard J. 
Published: February 2024

Abstract
Purpose of Review
To summarise the evidence regarding which patients might benefit from deprescribing antihypertensive medications.

Recent Findings
Older patients with frailty, multi-morbidity and subsequent polypharmacy are at higher risk of adverse events from antihypertensive treatment, and therefore may benefit from antihypertensive deprescribing. It is possible to examine an individual’s risk of these adverse events, and use this to identify those people where the benefits of treatment may be outweighed by the harms. While such patients might be considered for deprescribing, the long-term effects of this treatment strategy remain unclear.

Summary
Evidence now exists to support identification of those who are at risk of adverse events from antihypertensive treatment. These patients could be targeted for deprescribing interventions, although the long-term benefits and harms of this approach are unclear.

Perspectives
Randomised controlled trials are still needed to examine the long-term effects of deprescribing in high-risk patients with frailty and multi-morbidity.
The Application of Aptamer and Research Progress in Liver Disease
Authors: Xu Cheng , Tan Yong , Zhang Li-Ye , Luo Xiao-Jie , Wu Jiang-Feng , Ma Lan , Deng Fei 
Published: February 2024

Abstract
Aptamers, as a kind of small-molecule nucleic acid, have attracted much attention since their discovery. Compared with biological reagents such as antibodies, aptamers have the advantages of small molecular weight, low immunogenicity, low cost, and easy modification. At present, aptamers are mainly used in disease biomarker discovery, disease diagnosis, treatment, and targeted drug delivery vectors. In the process of screening and optimizing aptamers, it is found that there are still many problems need to be solved such as the design of the library, optimization of screening conditions, the truncation of screened aptamer, and the stability and toxicity of the aptamer. In recent years, the incidence of liver-related diseases is increasing year by year and the treatment measures are relatively lacking, which has attracted the people’s attention in the application of aptamers in liver diseases. This article mainly summarizes the research status of aptamers in disease diagnosis and treatment, especially focusing on the application of aptamers in liver diseases, showing the crucial significance of aptamers in the diagnosis and treatment of liver diseases, and the use of Discovery Studio software to find the binding target and sequence of aptamers, and explore their possible interaction sites.

Graphical Abstract
Analytical Modeling of [001] Orientation in Silicon Trigate Rectangular Nanowire Using a Tight-Binding Model
Authors: Paramasivam Pattunnarajam , Gowthaman Naveenbalaji , Srivastava Viranjay M. 
Published: February 2024

AbstractIn the realm of electronics, the performance of Silicon Trigate Rectangular Nanowires (Si-TRNW) and the structural characteristics of <001> orientation using tight-binding models have been analyzed. The fast algorithm based on the tight-binding model for Trigate Silicon nanowires yielded a remarkable ION/IOFF ratio of 1.49 × 1010 and leakage current (ILeak or IOFF) of 3.7 × 10−17μA. Furthermore, a maximum conduction band energy level (Ecmax) of −0.003 eV and a Subthreshold Slope (SS) of 120 mV has been obtained for a channel length of 15 nm. At an energy level of 3 eV, a high Transmission coefficient, T(ε), of 4 has been attained using the E-k dispersion method. This analysis also involved the calculation of three ∆ valleys pertinent to the channel’s effectiveness in <001> orientation, with proximity nearer to 1 m0. The Schrodinger-Poisson equation has been analyzed with the Ballistic transport along the [001] z-direction in channel potential. A comparative assessment has been also performed between the lateral dimensions of rectangular nanowires with equal energy levels, utilizing both the tight-binding model and Density Functional Theory (DFT) techniques. In some high-frequency applications, a high transmission coefficient is beneficial to maximize the amount of energy or information that gets transmitted. Reducing leakage current would offer a technological pathway for performance improvement of high-frequency applications. The high ON-current (ION) has been obtained through the DFT approach between source and drain terminals is particularly desirable for applications demanding for fast switching speeds and high-performance computing. The strengths of both methods in hybrid approaches is a common strategy to achieve simulations that are both accurate and efficient. Notably, the nanowires subjected to hydrostatic strain, exhibiting enhanced mobility and exceptional electrostatic integrity, emerged as pivotal components for forthcoming technology nodes. This research augments the potential feasibility of strain-based Si nanowires, even at the 3 nm scale, in subsequent technological advancements.
Predicting the coefficient of friction in a sliding contact by applying machine learning to acoustic emission data
Authors: Gutierrez Robert , Fang Tianshi , Mainwaring Robert , Reddyhoff Tom 
Published: February 2024

AbstractIt is increasingly important to monitor sliding interfaces within machines, since this is where both energy is lost, and failures occur. Acoustic emission (AE) techniques offer a way to monitor contacts remotely without requiring transparent or electrically conductive materials. However, acoustic data from sliding contacts is notoriously complex and difficult to interpret. Herein, we simultaneously measure coefficient of friction (with a conventional force transducer) and acoustic emission (with a piezoelectric sensor and high acquisition rate digitizer) produced by a steel–steel rubbing contact. Acquired data is then used to train machine learning (ML) algorithms (e.g., Gaussian process regression (GPR) and support vector machine (SVM)) to correlated acoustic emission with friction. ML training requires the dense AE data to first be reduced in size and a range of processing techniques are assessed for this (e.g., down-sampling, averaging, fast Fourier transforms (FFTs), histograms). Next, fresh, unseen AE data is given to the trained model and the resulting friction predictions are compared with the directly measured friction. There is excellent agreement between the measured and predicted friction when the GPR model is used on AE histogram data, with root mean square (RMS) errors as low as 0.03 and Pearson correlation coefficients reaching 0.8. Moreover, predictions remain accurate despite changes in test conditions such as normal load, reciprocating frequency, and stroke length. This paves the way for remote, acoustic measurements of friction in inaccessible locations within machinery to increase mechanical efficiency and avoid costly failure/needless maintenance.
Decentralized Clinical Trials in the Development of Drugs and Biological Products
Authors: Robinson Ryan , Sacks Leonard 
Published: February 2024

AbstractDecentralized clinical trials (DCTs) are trials where some or all of the trial-related activities occur at locations other than traditional clinical trial sites. FDA supports decentralization to improve participation in clinical trials. While there are benefits of DCTs, including convenience for participants, sponsors and investigators should be aware of potential challenges such as coordination of trial activities at locations other than traditional trial sites and supervision of delegated trial-activities performed remotely. Appropriate training, oversight, and up-front risk assessment and management will be key to implementing a DCT successfully.
Germicidal efficacy of continuous and pulsed ultraviolet-C radiation on pathogen models and SARS-CoV-2
Authors: Rufyikiri Anne Sophie , Martinez Rebecca , Addo Philip W. , Wu Bo-Sen , Yousefi Mitra , Malo Danielle , Orsat Valérie , Vidal Silvia M. , Fritz Jörg H. , MacPherson Sarah , Lefsrud Mark 
Published: February 2024

AbstractUltraviolet radiation’s germicidal efficacy depends on several parameters, including wavelength, radiant exposure, microbial physiology, biological matrices, and surfaces. In this work, several ultraviolet radiation sources (a low-pressure mercury lamp, a KrCl excimer, and four UV LEDs) emitting continuous or pulsed irradiation were compared. The greatest log reductions in E. coli cells and B. subtilis endospores were 4.1 ± 0.2 (18 mJ cm−2) and 4.5 ± 0.1 (42 mJ cm−2) with continuous 222 nm, respectively. The highest MS2 log reduction observed was 2.7 ± 0.1 (277 nm at 3809 mJ cm−2). Log reductions of SARS-CoV-2 with continuous 222 nm and 277 nm were ≥ 3.4 ± 0.7, with 13.3 mJ cm−2 and 60 mJ cm−2, respectively. There was no statistical difference between continuous and pulsed irradiation (0.83–16.7% [222 nm and 277 nm] or 0.83–20% [280 nm] duty rates) on E. coli inactivation. Pulsed 260 nm radiation (0.5% duty rate) at 260 nm yielded significantly greater log reduction for both bacteria than continuous 260 nm radiation. There was no statistical difference in SARS-CoV-2 inactivation between continuous and pulsed 222 nm UV-C radiation and pulsed 277 nm radiation demonstrated greater germicidal efficacy than continuous 277 nm radiation. Greater radiant exposure for all radiation sources was required to inactivate MS2 bacteriophage. Findings demonstrate that pulsed irradiation could be more useful than continuous UV radiation in human-occupied spaces, but threshold limit values should be respected. Pathogen-specific sensitivities, experimental setup, and quantification methods for determining germicidal efficacy remain important factors when optimizing ultraviolet radiation for surface decontamination or other applications.
Graphical abstract
“All the world at the palm of the hand”: imagining history through the life of an early Afghan saint
Authors: Ahmed Tanvir 
Published: February 2024

AbstractIn this article I explore hagiographical narratives about Khwāja Yaḥyā Kabīr (d. 1430), among the earliest of the Sufi masters to be identified as Afghan. The social memory of Yaḥyā Kabīr's life exemplifies the function of hagiography as a key arena for the production of historical knowledge, generating a vivid and specific imaginary of the past for devotees. My goal here is to present a reading of the hagiography, but first I will situate it within the discursive nexus of Persian historical writing, which often essentialized Afghans as innately barbarous while peripheralizing Afghan homelands (identified with the Sulaiman Mountains). Yaḥyā Kabīr's hagiography is both reflective of Indo-Afghan anxieties about social hierarchies and a device by which marginalizing traditions could be subverted through a highly textured portrayal of the past. As such, it exemplifies how saints’ lives can index not only the hierarchies of imperial life, but also the techniques by which to escape them.
Seroconversion and seroprevalence of TORCH infections in a pregnant women cohort study, Mombasa, Kenya, 2017–2019
Authors: Hunsperger Elizabeth , Osoro Eric , Munyua Peninah , Njenga M. Kariuki , Mirieri Harriet , Kikwai Gilbert , Odhiambo Dennis , Dayan Moshe , Omballa Victor , Agogo George O. , Mugo Cyrus , Widdowson Marc-Alain , Inwani Irene 
Published: February 2024

Abstract
Women infected during pregnancy with TORCH (Toxoplasmosis, Other, Rubella, Cytomegalovirus, and Herpes simplex viruses) pathogens have a higher risk of adverse birth outcomes including stillbirth / miscarriage because of mother-to-child transmission. To investigate these risks in pregnant women in Kenya, we analyzed serum specimens from a pregnancy cohort study at three healthcare facilities. A sample of 481 participants was selected for TORCH pathogen antibody testing to determine seroprevalence. A random selection of 285 from the 481 participants was selected to measure seroconversion. These sera were tested using an IgG enzyme-linked immunosorbent assay against 10 TORCH pathogens. We found that the seroprevalence of all but three of the 10 TORCH pathogens at enrollment was >30%, except for Bordetella pertussis (3.8%), Treponema pallidum (11.4%), and varicella zoster virus (0.5%). Conversely, very few participants seroconverted during their pregnancy and were herpes simplex virus type 2 (n = 24, 11.2%), parvovirus B19 (n = 14, 6.2%), and rubella (n = 12, 5.1%). For birth outcomes, 88% of the participant had live births and 12% had stillbirths or miscarriage. Cytomegalovirus positivity at enrolment had a statistically significant positive association with a live birth outcome (p = 0.0394). Of the 10 TORCH pathogens tested, none had an association with adverse pregnancy outcome.
Visualising Success: the Kanban Approach to Improving Collaboration and Communication in the Library
Authors: Griffiths Laura , Tyson Alice 
Published: February 2024

AbstractKanban is a framework that is commonly used in the technology sector and other industries to help teams work more effectively, but it has not been widely adopted in LIS contexts. As many of us continue to adapt to hybrid workplaces, kanban could prove to be a useful tool for organising work and communicating. In this article Laura Griffiths and Alice Tyson of the IALS Library explain how Kanban boards work and offer a case study of how a Kanban board was used in a recent project at the IALS Library. The article also discusses the wider value of kanban to the LIS sector.
What is Public Information Online?
Authors: Ravenhill Donna 
Published: February 2024

AbstractPublic Information Online (PIO) is an online service from Dandy Booksellers Ltd offering a wide range of official documents going back, in many cases, more than a century. PIO is safeguarding the accessibility to historic government decisions which have changed the face of our constitution. Here Donna Ravenhill, Managing Director of Dandy Booksellers, takes LIM through the origins and history of PIO, explains how you can make the most of its facilities, and outlines its plans for the future.
A Critical Appraisal of the Sensitivity of Detrital Zircon U–Pb Provenance Data to Constrain Drainage Network Evolution in Southeast Tibet
Authors: Li Shihu , Najman Yani , Vermeesch Pieter , Barfod Dan N. , Millar Ian , Carter Andy 
Published: February 2024

AbstractProvenance tools, particularly detrital zircon U–Pb analysis, have been widely employed to test drainage network evolution in southeast Tibet and its linkage with the growth of the Tibetan Plateau. Numerous provenance studies have been conducted on the sediments in the paleo‐Yangtze and paleo‐Red River drainage basins. Nevertheless, it is still hotly debated as to whether a “Mississippi” (dendritic) pattern Greater paleo‐Red River, originating from southeast Tibet and draining to the South China Sea, existed in the early Cenozoic, and was subsequently captured by the paleo‐lower Yangtze due to uplift of southeastern Tibet. In this study, in addition to presenting new data from the Gonjo and Jianchuan basins along which the Greater paleo‐Red River is proposed to have flowed, we compiled all the published detrital zircon U–Pb data from the paleo‐upper Yangtze and paleo‐Red River drainage basins from Triassic and younger rocks. Our large database of detrital zircon U–Pb analyses shows that the different terranes in the paleo‐upper Yangtze and paleo‐Red River drainage basins have similar zircon U–Pb signatures since the Late Triassic closure of the Paleo‐Tethys Ocean. Therefore, most of the sediments in the Cenozoic sedimentary basins in southeast Tibet could have been either deposited by long‐distance transport in large rivers from southeast Tibet or recycled from local bedrock. Given the potential importance of sedimentary recycling that we have demonstrated, this poses challenges to the use of detrital zircon U–Pb analyses to determine paleodrainage in this region. We therefore further explored the previously relatively limited use of Sr–Nd isotopes on mudstones and detrital mica 40Ar/39Ar ages, with new analyses from the Gonjo and Jianchuan Basins, to determine if these techniques were better suited to reconstruct paleodrainage evolution. Whilst these techniques do show some promise, more analyses and strategic sampling are required to obtain a full understanding of the extent of their potential utility. Overall, our integrated provenance study indicates that the available data are not sufficiently conclusive to support or refute the Greater paleo‐Red River capture model.
Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures
Authors: Podvin Sonia , Jones Jeffrey , Kang Austin , Goodman Ryan , Reed Patrick , Lietz Christopher B. , Then Joshua , Lee Kelly C. , Eyler Lisa T. , Jeste Dilip V. , Gage Fred H. , Hook Vivian 
Published: February 2024

AbstractSchizophrenia (SZ) is a serious mental illness and neuropsychiatric brain disorder with behavioral symptoms that include hallucinations, delusions, disorganized behavior, and cognitive impairment. Regulation of such behaviors requires utilization of neurotransmitters released to mediate cell-cell communication which are essential to brain functions in health and disease. We hypothesized that SZ may involve dysregulation of neurotransmitters secreted from neurons. To gain an understanding of human SZ, induced neurons (iNs) were derived from SZ patients and healthy control subjects to investigate peptide neurotransmitters, known as neuropeptides, which represent the major class of transmitters. The iNs were subjected to depolarization by high KCl in the culture medium and the secreted neuropeptides were identified and quantitated by nano-LC-MS/MS tandem mass spectrometry. Several neuropeptides were identified from schizophrenia patient-derived neurons, including chromogranin B (CHGB), neurotensin, and natriuretic peptide. Focusing on the main secreted CHGB neuropeptides, results revealed differences in SZ iNs compared to control iN neurons. Lower numbers of distinct CHGB peptides were found in the SZ secretion media compared to controls. Mapping of the peptides to the CHGB precursor revealed peptides unique to either SZ or control, and peptides common to both conditions. Also, the iNs secreted neuropeptides under both KCl and basal (no KCl) conditions. These findings are consistent with reports that chromogranin B levels are reduced in the cerebrospinal fluid and specific brain regions of SZ patients. These findings suggest that iNs derived from SZ patients can model the decreased CHGB neuropeptides observed in human SZ.
YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression
Authors: Xiao Yao , Zhou Linli , Andl Thomas , Zhang Yuhang 
Published: February 2024

AbstractThe hallmark of epithelial-to-mesenchymal transition (EMT) is the switch from epithelial cadherin (E-cadherin) to neural cadherin (N-cadherin), allowing melanoma cells to form a homotypic N-cadherin-mediated adhesion with stromal fibroblasts. However, how cadherin switching is initiated, maintained, and regulated in melanoma remains elusive. Here, we report a novel mechanism underlying cadherin switching in melanoma cells that is regulated by stromal Yes-associated protein 1 (YAP1) signaling. The progression of a BRAF-mutant mouse melanoma was suppressed in vivo upon YAP1 ablation in cancer-associated fibroblasts (CAFs). On the contrary, overexpressing YAP1 in CAFs accelerated melanoma development. By RNA-Seq, N-cadherin was identified as a major downstream effector of YAP1 signaling in CAFs. YAP1 silencing reduced N-cadherin expression in CAFs, leading to the downregulation of N-cadherin in neighboring melanoma cells. N-cadherin ablation inhibited the PI3K-AKT signaling pathway in melanoma cells and melanoma cell proliferation. The findings suggest that YAP1 depletion in CAFs induces the downregulation of p-AKT signaling in melanoma cells through the N-cadherin-mediated interaction between melanoma cells and CAFs. The data underscore an important role of CAFs in regulating N-cadherin-mediated adhesion and signaling in melanoma and highlight that disentangling cadherin-mediated cell-cell interactions can potentially disrupt tumor-stroma interactions and reverse the tumor cell invasive phenotype.