bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upregulation of IFNE in cervical biopsies of patients with high‐risk human papillomavirus infections
Authors: Zhang Lu , Zhou Yuechen , Xing Xiaoyan , Li Hua , Zhang Zhan , Qian Ruiya , Hu Xiaoyu 
Published: December 2023

AbstractProblemInterferon epsilon (IFN‐ε) is constitutively expressed in the epithelium of female reproductive tract and confers vital protection against sexually transmitted pathogens in mouse models. However, there is limited insight into the role of IFN‐ε in human sexually transmitted infections such as human papillomavirus (HPV).Method of StudyCervical biopsies were obtained from high‐risk (HR) HPV positive (n = 28) and HR‐HPV negative (n = 10) women. mRNA expression of IFN‐ε in cervical tissues was measured by qPCR. Expression of the IFN‐ε protein was determined by Western blot analysis, immunohistochemistry and immunofluorescence staining.ResultsmRNA expression of IFN‐ε was higher in the ectocervix than that of other IFNs, and was further upregulated in HR‐HPV positive women compared with HR‐HPV negative women. Expression of the IFN‐ε protein was comparable between HR‐HPV infected patients and healthy controls.ConclusionsThese results reveal differential expression of IFN‐ε mRNA between individuals with or without HR‐HPV infection, and imply direct or indirect regulatory mechanisms for IFN‐ε transcription by HPV. Expression of IFN‐ε protein in HPV infections would require further validation.
Effect of a brief alcohol counselling intervention on HIV viral suppression and alcohol use among persons with HIV and unhealthy alcohol use in Uganda and Kenya: a randomized controlled trial
Authors: Puryear Sarah B. , Mwangwa Florence , Opel Fred , Chamie Gabriel , Balzer Laura B. , Kabami Jane , Ayieko James , Owaraganise Asiphas , Kakande Elijah , Agengo George , Bukusi Elizabeth , Kabageni Stella , Omoding Daniel , Bacon Melanie , Schrom John , Woolf‐King Sarah , Petersen Maya L. , Havlir Diane V. , Kamya Moses , Hahn Judith A. 
Published: December 2023

AbstractIntroductionUnhealthy alcohol use significantly contributes to viral non‐suppression among persons with HIV (PWH). It is unknown whether brief behavioural interventions to reduce alcohol use can improve viral suppression among PWH with unhealthy alcohol use in sub‐Saharan Africa (SSA).MethodsAs part of the SEARCH study (NCT04810650), we conducted an individually randomized trial in Kenya and Uganda of a brief, skills‐based alcohol intervention among PWH with self‐reported unhealthy alcohol use (Alcohol Use Disorders Identification Test–Consumption [AUDIT‐C], prior 3 months, ≥3/female; ≥4/male) and at risk of viral non‐suppression, defined as either recent HIV viral non‐suppression (≥400 copies/ml), missed visits, out of care or new diagnosis. The intervention included baseline and 3‐month in‐person counselling sessions with interim booster phone calls every 3 weeks. The primary outcome was HIV viral suppression (<400 copies/ml) at 24 weeks, and the secondary outcome was unhealthy alcohol use, defined by AUDIT‐C or phosphatidylethanol (PEth), an alcohol biomarker, ≥50 ng/ml at 24 weeks.ResultsBetween April and September 2021, 401 persons (198 intervention, 203 control) were enrolled from HIV clinics in Uganda (58%) and Kenya (27%) and alcohol‐serving venues in Kenya (15%). At baseline, 60% were virally suppressed. Viral suppression did not differ between arms at 24 weeks: suppression was 83% in intervention and 82% in control arms (RR: 1.01, 95% CI: 0.93–1.1). Among PWH with baseline viral non‐suppression, 24‐week suppression was 73% in intervention and 64% in control arms (RR 1.15, 95% CI: 0.93–1.43). Unhealthy alcohol use declined from 98% at baseline to 73% in intervention and 84% in control arms at 24 weeks (RR: 0.86, 95% CI: 0.79–0.94). Effects on unhealthy alcohol use were stronger among women (RR 0.70, 95% CI: 0.56–0.88) than men (RR 0.93, 95% CI: 0.85–1.01) and among participants with a baseline PEth⩽200 ng/ml (RR 0.68, 95% CI: 0.53–0.87) versus >200 ng/ml (RR 0.97, 95% CI: 0.92–1.02).ConclusionsIn a randomized trial of 401 PWH with unhealthy alcohol use and risk for viral non‐suppression, a brief alcohol intervention reduced unhealthy alcohol use but did not affect viral suppression at 24 weeks. Brief alcohol interventions have the potential to improve the health of PWH in SSA by reducing alcohol use, a significant driver of HIV‐associated co‐morbidities.
Determination of compounds with laxative action in aloe latex and aloe vera‐based products—Chemometric classification of aloe vera plants (Aloe barbadensis Miller) under different conditions
Authors: Ioannou Georgia D. , Christou Atalanti , Stavrou Ioannis J. , Kapnissi‐Christodoulou Constantina P. 
Published: December 2023

AbstractBackgroundThe bioactive compounds of latex in aloe vera are associated with several of its medicinal properties. Aloe emodin, aloins A and B, which are present in aloe latex, are known for their laxative action.ResultsThe developed HPLC method for the determination of compounds with purgative effect was performed with a C18 column, and the total analysis time was 22 min. Each leaf from the plants was studied separately for its content in aloins. It was observed that, in contrast with field cultivation plants, the concentrations of aloins in potted plants follow a specific pattern based on the position of the leaves. It was also observed that climatic and environmental conditions have a significant impact on the concentrations of aloins. Principal Component Analysis was performed to evaluate correlations among measurements. The model was able to separate the aloe plants based on their seasonal variation and growing conditions. Finally, it was observed that, in only two out of thirteen products, aloins were present, with the total content exceeding the maximum levels set by EU legislation.ConclusionThe present work provides useful information for the aloins variation among leaves in different positions and plants under various conditions.
CO2 laser deroofing technique: A robust and effective treatment for hidradenitis suppurativa regardless of comorbidities (a retrospective study of 334 lesions in 130 treated patients)
Authors: Schøsler Louise , Hedelund Lene , Rasmussen Mads K. 
Published: December 2023

AbstractBackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin disease that affects the terminal hair follicles in areas rich in apocrine glands. The condition most commonly manifests in the axillae, inframammary areas and genitofemoral region. Prevalence rates range between 1% and 4%. The management of HS encompasses both medical and surgical treatments, with surgical options including wide excision and carbon dioxide (CO2) laser‐assisted deroofing.ObjectivesThe aim of this study is to characterize patients with HS and to evaluate the efficacy of CO2 laser‐assisted deroofing technique in the treatment of chronic HS lesions with a particular focus on recurrence rates.MethodsThis retrospective study included a cohort of 130 Danish patients treated at the Department of Dermatology, Aarhus University Hospital, Denmark, over a 4‐year period. All participants met the established criteria for HS and were treated using the deroofing technique. Data were manually extracted from the electronic patient record and subjected to statistical analysis using Microsoft Excel 2016 and STATA version 15. Kaplan−Meier survival curves were generated, and comparisons were made using the Log‐rank test.ResultsA total of 334 lesions were treated using the deroofing technique; 15.4% had Hurley stage I, 56.9% had Hurley stage II and 27.7% Hurley stage III. Recurrence was seen in 59 of 334 lesions (17.7%), affecting a total of 47 patients. Risk of recurrence was highest during the first 20 months.ConclusionsThis study confirms that CO2 laser deroofing is an effective treatment for chronic HS elements, demonstrating a low recurrence rate. Results showed that factors such as age, sex, diabetes, smoking habits, location of the treated area and lesion size did not significantly influence the risk of recurrence. However, patients with a body mass index greater than 25 showed a borderline significant increased risk of recurrence. The deroofing technique is robust and serves as an important tool in the surgeon's armamentarium.
Cryoprotectants for red blood cells: Evaluate safety and effectiveness by in vitro measures
Authors: Hu Yuying , Liu Xiangjian , Ahmad AKhlaq , Chen Jiangming , Chen Xiaoxiao , Zhang Wenqian , Tan Songwen 
Published: December 2023

AbstractThe transfusion of red blood cells (RBCs) is crucial in current medicinal research. The shelf‐life of donated RBCs preserved by the normal method is very short, limiting their clinical application. Cryopreservation is a reliable and effective technology for the long‐term storage of RBCs. During the process, ice formation will cause irreversible injuries to RBCs. Glycerol is used as a cryoprotectant (CPA) for RBCs to mitigate cryoinjuries. But it severely induces RBC hemolysis and deformation. This review introduces some biocompatible and effective CPAs used for RBC cryopreservation, outlining recent advances. Currently, there is no uniform standard to determine whether a CPA is suitable for RBCs. According to previous studies, we summarize for the first time comprehensive methods to evaluate the performance of CPAs by ensuring their safety and effectiveness. The safety of CPAs is defined as the degree of damage to RBCs, while the effectiveness is demonstrated by the properties of thawed RBCs, including membrane properties, protein activities, rheological properties, and metabolites levels. A novel CPA that is confirmed suitable for RBCs by these methods may be applied to other cells. We believe comprehensive methods can thoroughly evaluate the performance of CPAs and promote the development of transfusion therapy in clinic.
Non‐invasive experiments on the fluid film behavior in a horizontal rotating cylinder
Authors: Sommer Oliver , la Monaca Andrea , Bretschneider Eric , Wozniak Günter 
Published: December 2023

AbstractSubject of our investigations is the spatial distribution of a Newtonian liquid within a partially filled horizontal rotating hollow cylinder in dependence of the variables angular velocity and angular acceleration, cylinder filling and cylinder geometry as well as viscosity of the liquid. We focus on the development of a thin liquid film at the inner cylinder wall. The layer thickness was measured using a non‐invasive laser‐induced fluorescence measurement technique. In addition, the liquid distribution and flow topologies were observed and described using optical measurements.The occurring liquid distributions can be distinguished in three different states. At low angular velocities most of the liquid is located at the bottom area of the cylinder. However, a thin liquid film is always pulled out of the reservoir from the rotating cylinder wall. With increasing angular velocity more and more liquid is deflected and the locally measured film thickness increases. Exceeding a critical angular velocity, a centrifuged distribution of the whole liquid establishes. In this state the measured film thickness fits the theoretical calculated value quite well. Very complex liquid distributions and flow patterns develop in particular at critical angular velocities. In detail, at all investigated cylinder systems two critical angular velocities were verifiable, the so‐called transition points of liquid distribution. At the first critical velocity, the centrifuged state develops. With deceleration of the system a second critical angular velocity exists. Below this value the centrifuged distribution of the liquid collapses and moves back again to the bottom of the cylinder. A thin film is still pulled out of this reservoir. The second critical angular velocity of the break down is always smaller compared to the first one at which the centrifuged state develops. Both of them can be influenced using the investigated parameters. Eventually, we show that the locally measured film thickness also depends on these parameters.
Treatment‐induced neuropathy of diabetes: an update
Authors: Quiroz‐Aldave Juan Eduardo , Concepción‐Zavaleta Marcio José , del Carmen Durand‐Vásquez María , Gamarra‐Osorio Elman Rolando , Alcalá‐Mendoza Rosa María , Puelles‐León Susan Luciana , Ildefonso‐Najarro Sofía , Concepción‐Urteaga Luis Alberto , Gonzáles‐Mendoza Jorge Estanislao , Paz‐Ibarra José 
Published: December 2023

Abstract
Background and aims: Treatment‐induced neuropathy of diabetes is an acute small‐fibre neuropathy associated with rapid glycaemia improvement.Methods: This study is a narrative review carried out based on a bibliographic review, using articles indexed in PubMed/Medline and Scielo.Results: This entity is more frequent in adult patients with poor previous glycaemic control. Its precise pathophysiology is unknown, but it is likely related to unrestored microcirculation changes that occurred during the hyperglycaemic period. It presents with intense, sudden neuropathic pain and autonomic dysfunction after a rapid glycaemic correction and a poorer analgesic response than in diabetic neuropathy.Conclusions: Since rapid glycaemia correction is the cause of this problem, clinical practice guidelines that can help physicians to prevent, diagnose and manage this entity should be developed. Copyright © 2023 John Wiley & Sons.
Teachers' needs for an FASD‐informed resource: A qualitative interview needs assessment based on the ADAPT‐ITT framework
Authors: Kautz‐Turnbull Carson , Speybroeck Emily , Rockhold Madeline , Petrenko Christie L. M. 
Published: December 2023

AbstractFetal alcohol spectrum disorders (FASD) represent a wide range of neurodevelopmental differences associated with prenatal alcohol exposure and are highly prevalent. The current study represents the initial stages in adapting the Families Moving Forward (FMF) Program, an evidence‐based behavioral consultation intervention for caregivers of children with FASD, to a website for teachers. Aims were to understand teachers' needs and preferences for an FASD‐informed intervention website and to assess the goodness of fit of the FMF Program to teachers and the school setting. Twenty‐three teachers with experience teaching students with FASD were interviewed. Interviews were conducted via Zoom and lasted about 53 min on average. Data were transcribed verbatim and analyzed using qualitative content analysis in Dedoose. Three overarching themes represented teachers' needs for an FASD‐informed resource: teachers need evidence‐based FASD information and strategies, teachers have very little extra time, and the needs of special and general education teachers vary. Teachers were positive about the concepts of the FMF Program and felt they would have good fit. Teachers need an evidence‐based FASD‐informed intervention that is easy to use, concise, and responsive to varying needs and levels of experience. Results will inform the adaptation process of the FMF Program.
From Short‐ to Long‐Range Chiral Recognition on Surfaces: Chiral Assembly and Synthesis
Authors: Peng Xinchen , Zhang Yinhui , Liu Xinbang , Qian Yinyue , Ouyang Zuoling , Kong Huihui 
Published: December 2023

AbstractResearch on chiral behaviors of small organic molecules at solid surfaces, including chiral assembly and synthesis, can not only help unravel the origin of the chiral phenomenon in biological/chemical systems but also provide promising strategies to build up unprecedented chiral surfaces or nanoarchitectures with advanced applications in novel nanomaterials/nanodevices. Understanding how molecular chirality is recognized is considered to be a mandatory basis for such studies. In this review, a series of recent studies in chiral assembly and synthesis at well‐defined metal surfaces under ultra‐high vacuum conditions are outlined. More importantly, the intrinsic mechanisms of chiral recognition are highlighted, including short/long‐range chiral recognition in chiral assembly and two main strategies to steer the reaction pathways and modulate selective synthesis of specific chiral products on surfaces.
Modulating Electronic Structure and Atomic Insights into the Novel Hierarchically Porous PdCuFe Trimetallic Alloy Aerogel for Efficient Oxygen Reduction
Authors: Wu Xiaodong , Liu Liu , Yuan Ke , Shao Yitian , Shen Xiaodong , Cui Sheng , Chen Xiangbao 
Published: December 2023

AbstractThe high cost of noble Pd/Pt required for the oxygen reduction reaction (ORR) in the cathode restricts the wide applications of fuel cells. In this study, the synthesis of a novel Pd3CuFe0.5 aerogel electrocatalyst is successfully demonstrated using self‐assembly and lyophilization techniques, employing a mild reducing agent. The resulting aerogel electrocatalyst exhibits a distinctive 3D network structure, possessing a substantial BET‐specific surface area of 75.19 m2 g−1. It is worth noting that the optimized Pd3CuFe0.5 aerogel demonstrates exceptional ORR performance with a high half‐wave potential of 0.92 V versus RHE, a significant limiting current density of 7.6 mA cm−2, and the excellent electrocatalytic stability, superior to the reported noble metal electrocatalysts, with the ORR activity decays only 4.9% after 16 000 s. In addition, the Pd3CuFe0.5 aerogel electrocatalyst shows superior cycling stability for ≈120 h at a charge/discharge current density of 10 mA cm−2, indicating its promising application in fuel cells. Furthermore, the resulting composite aerogel possesses excellent hydrogen evolution reaction and ethanol oxidation reaction activity. The density functional theory calculations show that the partial oxidation of Pd3CuFe0.5 aerogel leads to a negative shift of the d‐band center, which energetically optimizes the binding strength of *O intermediates, therefore accelerating the ORR activity.
In Situ Interfacial Engineering of CeO2/Bi2WO6 Heterojunction with Improved Photodegradation of Tetracycline and Organic Dyes: Mechanism Insight and Toxicity Assessment
Authors: Chen Qian , Ning Shunyan , Yang Jingren , Wang Longfei , Yin Xiangbiao , Wang Xinpeng , Wei Yuezhou , Zeng Deqian 
Published: December 2023

AbstractThe construction of heterojunction photocatalysts is an auspicious approach for enhancing the photocatalytic performance of wastewater treatment. Here, a novel CeO2/Bi2WO6 heterojunction is synthesized using an in situ liquid‐phase method. The optimal 15% CeO2/Bi2WO6 (CBW‐15) is found to have the highest photocatalytic activity, achieving a degradation efficiency of 99.21% for tetracycline (TC), 98.43% for Rhodamine B (RhB), and 94.03% for methylene blue (MB). The TC removal rate remained at 95.38% even after five cycles. Through active species capture experiments, •O2−, h+, and •OH are the main active substances for TC, RhB, and MB, respectively. The possible degradation pathways for TC are analyzed using liquid chromatography‐mass spectrometry (LC‐MS). The photoinduced charge transfer and possible degradation mechanisms are proposed through experimentation and density functional theory (DFT) calculations. Toxicity assessment experiments show a significant reduction in toxicity during the TC degradation process. This study uncovers the mechanism of photocatalytic degradation in CeO2/Bi2WO6 and provides new insights into toxicity assessment.
All Plant‐Based Compact Supercapacitor in Living Plants
Authors: Gao Chang , Gu Yuyang , Liu Qing , Lin Weihu , Zhang Bin , Lin Xiangyun , Wang Haozhen , Zhao Yang , Qu Liangti 
Published: December 2023

AbstractBiomass‐based energy storage devices (BESDs) have drawn much attention to substitute traditional electronic devices based on petroleum or synthetic chemical materials for the advantages of biodegradability, biocompatibility, and low cost. However, most of the BESDs are almost made of reconstructed plant materials and exogenous chemical additives which constrain the autonomous and widespread advantages of living plants. Herein, an all‐plant‐based compact supercapacitor (APCSC) without any nonhomologous additives is reported. This type of supercapacitor formed within living plants acts as a form of electronic plant (e‐plant) by using its tissue fluid electrolyte, which surprisingly presents a satisfying electrical capacitance of 182.5 mF cm−2, higher than those of biomass‐based micro‐supercapacitors reported previously. In addition, all constituents of the device come from the same plant, effectively avoid biologically incompatible with other extraneous substances, and almost do no harm to the growth of plant. This e‐plant can not only be constructed in aloe, but also be built in most of succulents, such as cactus in desert, offering timely electricity supply to people in extreme conditions. It is believed that this work will enrich the applications of electronic plants, and shed light on smart botany, forestry, and agriculture.
Vacancy‐Rich Bismuth‐Based Nanosheets for Mitochondrial Destruction via CO Poisoning, Ca2+ Dyshomeostasis, and Oxidative Damage
Authors: Zhao Yinmin , Wang Xiaoqin , He Mengting , Zeng Guicheng , Xu Zhigang , Zhang Lei , Kang Yuejun , Xue Peng 
Published: December 2023

AbstractMitochondria are core regulators of tumor cell homeostasis, and their damage has become an arresting therapeutic modality against cancer. Despite the development of many mitochondrial‐targeted pharmaceutical agents, the exploration of more powerful and multifunctional medications is still underway. Herein, oxygen vacancy‐rich BiO2‐x wrapped with CaCO3 (named BiO2‐x@CaCO3/PEG, BCP) is developed for full‐fledged attack on mitochondrial function. After endocytosis of BCP by tumor cells, the CaCO3 shell can be decomposed in the acidic lysosomal compartment, leading to immediate Ca2+ release and CO2 production in the cytoplasm. Near‐infrared irradiation enhances the adsorption of CO2 onto BiO2‐x defects, which enables highly efficient photocatalysis of CO2‐to‐CO. Meanwhile, such BiO2‐x nanosheets possess catalase‐, peroxidase‐ and oxidase‐like catalytic activities under acidic pH conditions, allowing hypoxia relief and the accumulation of diverse reactive oxygen species (ROS) in the tumor microenvironment. Ca2+ overload‐induced ion dyshomeostasis, CO‐mediated respiratory chain poisoning, ROS‐triggered oxidative stress aggravation, and cytosolic hyperoxia can cause severe mitochondrial disorders, which further lead to type I cell death in carcinoma. Not only does BCP cause irreversible apoptosis, but immunogenic cell death is simultaneously triggered to activate antitumor immunity for metastasis inhibition. Collectively, this platform promises high benefits in malignant tumor therapy and may expand the medical applications of bismuth‐based nanoagents.
Mesoporous Nickel Sulfide Microsphere Encapsulated in Nitrogen, Sulfur Dual‐Doped Carbon with Large Subsurface Region for Enhanced Sodium Storage
Authors: Zhu Huijuan , Liu Qiming , Cao Shiyue , Chen Hongyi , Liu Yirui 
Published: December 2023

AbstractNickel sulfides are promising anode candidates in sodium ion batteries (SIBs) due to high capacity and abundant reserves. However, their applications are restricted by poor cycling stability and slow reaction kinetics. Thus, mesoporous nickel sulfide microsphere encapsulated in nitrogen, sulfur dual‐doped carbon (MNS@NSC) is prepared. The packaged structure and carbon matrix restrain the volume variation together, the N, S dual‐doping improves the electronic conductivity and offers extra active sites for sodium storage. Ex‐situ X‐ray diffraction appeals copper collector adsorbs polysulfide to inhibit the polysulfide accumulation and enhance conductivity. Moreover, the large subsurface attributed to C‐S‐S‐C bonding further boosts pseudocapacitive capacity, conducive to charge transfer. As a result, MNS@NSC delivers a high reversible capacity of 640.2 mAh g−1 after 100 cycles at 0.1 A g−1, an excellent rate capability (569.8 mAh g−1 at 5 A g−1), and a remained capacity of 513.8 mAh g−1 after undergoing 10000 circulations at 10 A g−1. The MNS@NSC|| Na3V2(PO4)3 full cell shows a cycling performance of specific capacity of 230.8 mAh g−1 after 100 cycles at 1 A g−1. This work puts forward a valid strategy of combing structural design and heteroatom doping to synthesize high‐performance nickel sulfide materials in SIBs.