bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning analytics to explore the motivational profiles of non-traditional practical nurse students: a mixed-methods approach
Authors: Kleimola Riina , López-Pernas Sonsoles , Väisänen Sanna , Saqr Mohammed , Sointu Erkko , Hirsto Laura 
Published: October 2023

AbstractLearning analytics provides a novel means to examine various aspects of students’ learning and to support them in their individual endeavors. The purpose of this study was to explore the potential of learning analytics to provide insights into non-traditional, vocational practical nurse students’ (N = 132) motivational profiles for choosing their studies, using a mixed-methods approach. Non-traditional students were somewhat older learners than those following a more straightforward educational pathway and had diverse educational or professional backgrounds. Institutional admission data and analytics were used to identify their specific study motives and distinct motivational profiles, and to illustrate the connections between the motives emerging in the motivational profiles. Furthermore, the association between the motivational profiles and study performance was examined. The results of qualitative content analysis indicated that non-traditional practical nurse students pursued such specialized training for various reasons, and that pragmatic, professional rationales were emphasized over prosocial, altruistic factors. Through the adoption of person-centered latent class analysis, three motivational profiles were identified: self-aware goal-achievers, qualification attainers, and widely oriented humanitarians. Additionally, the analyses of epistemic networks for the profiles showed the complex interplay between the motives, confirming that some motive connections appear to be more prominent than others. Moreover, the findings indicated that study motives reported at admission did not seem to dictate students’ later study performance, as no statistically significant associations were found between the motivational profile and the students’ final grade point average or study dropout. This investigation paves the way for more-targeted motivational support and the use of learning analytics in the context of vocational education and training.
Intermittent fasting: consider the risks of disordered eating for your patient
Authors: Blumberg Jack , Hahn Samantha L. , Bakke Jesse 
Published: October 2023

AbstractThis is a commentary on “Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians” by Albosta et al. While this article adequately summarized the biochemical clinical advantages and limitations, we feel it failed to mention a few drawbacks, primarily the risk for disordered eating and eating disorders. Here we delve into the emerging data on intermittent fasting or time-restricted feeding in patient populations and urge clinicians to consider these risks prior to encouragement of intermittent fasting.
A bispectral index guided comparative evaluation of dexmedetomidine as an adjuvant to propofol-based total intravenous anaesthesia in spine surgeries done under motor-evoked potential monitoring
Authors: Anand Anshuman , Kumar Suraj , Kumar Virendra , Giri Manoj Kumar , Das Praveen Kumar , Sharma Deepti 
Published: October 2023

Abstract
Background
The anaesthetic agents can affect the quality of motor-evoked potential intraoperatively as they inhibit synaptic transmission. Intravenous anaesthetics suppress motor-evoked potential lesser than inhalational agents, so total intravenous anaesthesia or a combination of intravenous with minimal inhalational anaesthetic supplementation is used when motor-evoked potential is monitored. Motor-evoked potential can get depressed at high doses of propofol required to maintain surgical depth, hence, adjuvant agents like dexmedetomidine that maintain anaesthetic depth without affecting the motor-evoked potential are often required. This study was a prospective non-randomized and comparative study (quasi-experimental) assigned into two groups of 64 each, labelled as the propofol group (group P) and Propofol + dexmedetomidine group (group PD). The primary objective of our study was to compare the total dose reduction of propofol with the addition of dexmedetomidine and their interference with motor-evoked potential readings. The secondary objective was to assess the hemodynamic changes, changes in amplitude and latency of motor-evoked potential, and complications if any.

Results
The mean total dose of propofol consumed in our study was 502.81 ± 71.01 mg in group propofol( P) and 392.18 ± 59.00 mg in group propofol + dexmedetomidine (PD). Moreover, the mean total dose of propofol (mg) was significantly less used in group PD. Intraoperative hemodynamic stability, no difference in amplitude and latency for motor-evoked potential, and only significant bradycardia in group propofol + dexmedetomidine (PD).

Conclusions
Dexmedetomidine can be successfully used in propofol-based total intravenous anaesthesia for motor-evoked potential monitoring in spine surgeries, but it is better to maintain stable hemodynamics with a significant reduction of the mean dose of propofol.
A glance on Immunogenetics Laboratory: from the origins to the future
Authors: Madalese Donato , Casalino Rosaria , Auriemma Laura , Colucci Rosa , Di Maio Antonio , Tambaro Francesco Paolo , de Vera d’Aragona Roberta Penta 
Published: October 2023

AbstractHistocompatibility and Immunogenetics (H&I) laboratories have currently a significant relevance in clinical and research medical fields. The purpose of this review is to investigate their role through an excursus between bioethics, histocompatibility history and laboratory organization. The histocompatibility laboratories play an essential role in the transplantation process, and, through their molecular techniques, they can affect clinical decisions in a remarkable way. Half a century has passed from the first paper, published in 1958, to the modern deep sequencing techniques; in these years through specific guidelines and international standards drafted by 2 specific bodies (ASHI and EFI), H&I laboratories are subjected to continuous controls by inspection authorities formed by professionals in the Immunogenetics field. For their functioning, H&I laboratories require: a structure and devices, a dedicated room and a clear path to samples workflow. In these laboratories, the personnel must be specialized even just in a single precise assignment, and every member is assigned to a role according to the experience matured over the years. In these laboratories, the role of Director/Co-Director or Technical Supervisor is usually assigned to a staff member with a minimum of 4 years of experience in Immunogenetics or transplantation fields, following the EFI/ASHI Standards. Bioethics is another important aspect because, in the last few years, there has been a major change in legal regulations on informed consent. The advent of digitization has pushed many laws on personal and genetic data treatment to be adapted to most modern guidelines, although they may differ according to the countries in Europe and USA. In the last years, the H&I laboratories turned as great resources with many clinical features and nowadays they may lead an important transformation in research and clinical fields.
Graphical abstract
Higher Maternal Body Mass Index Is Associated With Lower Placental Expression ofEPYC:A Genome-Wide Transcriptomic Study
Authors: Sordillo Joanne E , White Frédérique , Majid Sana , Aguet François , Ardlie Kristin G , Karumanchi S Ananth , Florez Jose C , Powe Camille E , Edlow Andrea G , Bouchard Luigi , Jacques Pierre-Etienne , Hivert Marie-France 
Published: October 2023

AbstractContextElevated body mass index (BMI) in pregnancy is associated with adverse maternal and fetal outcomes. The placental transcriptome may elucidate molecular mechanisms underlying these associations.ObjectiveWe examined the association of first-trimester maternal BMI with the placental transcriptome in the Gen3G prospective cohort.MethodsWe enrolled participants at 5 to 16 weeks of gestation and measured height and weight. We collected placenta samples at delivery. We performed whole-genome RNA sequencing using Illumina HiSeq 4000 and aligned RNA sequences based on the GTEx v8 pipeline. We conducted differential gene expression analysis of over 15 000 genes from 450 placental samples and reported the change in normalized gene expression per 1-unit increase in log2 BMI (kg/m2) as a continuous variable using Limma Voom. We adjusted models for maternal age, fetal sex, gestational age at delivery, gravidity, and surrogate variables accounting for technical variability. We compared participants with BMI of 18.5 to 24.9 mg/kg2 (N = 257) vs those with obesity (BMI ≥30 kg/m2, N = 82) in secondary analyses.ResultsParticipants’ mean ± SD age was 28.2 ± 4.4 years and BMI was 25.4 ± 5.5 kg/m2 in early pregnancy. Higher maternal BMI was associated with lower placental expression of EPYC (slope = −1.94, false discovery rate [FDR]-adjusted P = 7.3 × 10−6 for continuous BMI; log2 fold change = −1.35, FDR-adjusted P = 3.4 × 10−3 for BMI ≥30 vs BMI 18.5-24.9 kg/m2) and with higher placental expression of IGFBP6, CHRDL1, and CXCL13 after adjustment for covariates and accounting for multiple testing (FDR &lt; 0.05).ConclusionOur genome-wide transcriptomic study revealed novel genes potentially implicated in placental biologic response to higher maternal BMI in early pregnancy.
Structural and Functional Brain Changes After Glucocorticoid Therapy in Thyroid-Associated Ophthalmopathy
Authors: Wu Qian , Zhou Jiang , Fang Wei , Jiang Wen-Hao , Pu Xiong-Ying , Chen Huan-Huan , Xu Xiao-Quan , Hu Hao , Wu Fei-Yun 
Published: October 2023

Abstract

Objective
To investigate the brain structural and functional alterations in patients with thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid therapy, using voxel-based morphometry (VBM) as well as resting-state functional magnetic resonance imaging (MRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).

Methods
Between 2019 and 2022, 32 patients with TAO and 23 healthy controls underwent pre-therapy MRI in Nanjing, China. Intravenous glucocorticoid therapy was administered to all patients. At 3 months after end of therapy, 26 patients were available for rescanned MRI. VBM, ALFF, and ReHo were used to evaluate the brain structural and functional differences.

Results
Before therapy, TAO patients showed significantly decreased gray matter volume (GMV) in the left orbital part of superior frontal gyrus (ORBsup) and medial superior frontal gyrus (SFGmed) than healthy controls. Patients had higher ALFF values in bilateral gyrus rectus and olfactory cortex and lower values in bilateral cuneus. Patients also showed decreased ReHo values in bilateral lingual gyrus. After therapy, increased GMV in the left anterior cingulate gyrus and SFGmed, increased ALFF values in bilateral cuneus and superior occipital gyrus, and increased ReHo values in bilateral SFGmed were found in TAO patients compared to the pre-therapy cohort. Compared to controls, decreased GMV in left ORBsup was observed in post-therapy TAO patients.

Conclusion
Our results indicated that TAO might cause functional and structural deficits in the visual and emotional regions of the brain, with recovery in the former and partial restoration in the latter after effective glucocorticoid therapy. These findings may lead to deeper understanding of the pathophysiological mechanism behind TAO.
The association of positive sepsis PCRs tests with patient mortality, length of stay, and antibiotic management in a medical intensive care unit
Authors: Solis Ximena , Batson Ben , Morataya Cristina , Iwuji Kenneth , Fairley Hannah , Chakkour Wadih , Nugent Kenneth , Islam Ebtesam 
Published: October 2023

Background: Polymerase chain reaction (PCR) testing amplifies a specific DNA segment through heat cycling to identify pathogens for the diagnosis of infection. This testing allows for rapid detection of pathogens, before conventional blood culture results become available. The high mortality associated with severe sepsis and septic shock stresses the importance of early diagnosis and initiation of early antibiotic therapy. This study analyzed the association of the sepsis PCR results and antibiotic management, length of stay, and mortality outcomes in a medical intensive care unit (MICU).
Methods: This study is a retrospective, cross-sectional study on patients diagnosed with severe sepsis and septic shock based on ICD-10 codes, aged 18 years and older, admitted to the MICU at University Medical Center, Lubbock, Texas, between December 2016 to December 2020.
Results: Clinical information from 268 patients with the diagnosis of sepsis or septic shock was collected and analyzed. The mean age was 60.9 ± 15.6 years with a predominance of men (144, 53.7%) and Caucasian race (193,73.4%). A total of 101 patients (37.6%) had positive PCR results; overall, PCR test results had a diagnostic sensitivity of 91.2 %. The concordance between positive blood culture and positive PCR was 93.3 % (p <.0001). There was a significant correlation between PCR positivity and increased serum lactate levels (p=0.03), changes in antibiotics (P<0.00010), and increased mortality rate (p=0.04). There was no significant correlation between PCR positivity and length of stay (p=0.84).
Conclusion: In this study, PCR testing was an accurate tool for early identification of bacterial pathogens. A positive PCR was associated with higher serum lactate levels, higher mortality rates, and an increased frequency of antibiotic changes but was not associated with shorter ICU length of stay.
Key words: Sepsis, septic shock, PCR testing, outcomes
Investigation of the effect of HITT training applied to basketball players on sportive performance
Authors: Apaydın Murat Bekleyiş , Şengür Emrah , Turasan İzzet 
Published: October 2023

Sprint and agility are recognized as important elements for development in basketball. In addition, the effect of anaerobic performance parameters on efficiency scores in basketball players is recognized by coaches and athletic performance trainers. The aim of this study investigate the high-intensity interval training (HITT) effect on female basketball players in some of the performance parameters. The Research group (n=10) with is age mean of 15,74±,933year, body height of 169,95±5,22cm, and body weight of 63,63±9,25kg was applied a total of 16 HIIT training for eight weeks. Also, the control group was asked to continue field training and no training protocol was applied. Measurements were made on different days before the study and at the end of the 8th week. G*Power (1.3.9.4 version) was used to determine the sample size and SPSS 22 program was used to analyze the findings obtained from the measurements. After the training protocol was applied in the study, it was found that there was a significant difference (p<0.05) not only agility test but also in the 10-20-meter sprint performance measurements and basketball shooting test accuracy rates of basketball players (experimental group). As a result, it was determined that high-intensity interval training had a positive effect on agility and vertical jump and shouting tests.
(Extended English summary is at the end of this document)
Özet
Basketbol branşında sürat ve çeviklik gelişim için önemli bir unsur olarak kabul edilmektedir. Ayrıca anaerobik performans parametrelerine basketbolcularda verimlilik puanlarına etkisi antrenörler ve atletik performans uzmanları ttarafından kabul edilmektedir. Bu çalışmanın amacı kız basketbolculara uygulanan yüksek yoğunlukta aralıklı egzersizlerin (HITT) sportif performans üzerine etkisini tespit etmek amacıyla yapılmıştır. Araştırmada yaş ortalaması 15,74±,933yıl olan boy ortalaması 169,95±5,22cm vücut ağırlığı ortalaması 63,63±9,25kg olan deney grubuna (n=10) 8 hafta boyunca saha antrenmanlarına ek farklı günlerde haftada 2 gün toplam 16 HIIT antrenman protokolü uygulanmıştır. Kontrol grubuna ise saha antrenmanlarına devam etmeleri istenmiş ve herhangi bir antrenman protokolü uygulanmamıştır. Araştırma öncesi ve 8. haftanın bitiminde olmak üzere farklı günlerde ölçümler yapılmıştır. Örneklem büyüklüğü tespiti için G*Power (1.3.9.4) ölçümlerden elde edilen bulguların analizinde ise SPSS 22 programı kullanılmıştır. Araştırmada uygulanan antrenman protokolü sonrası basketbolcularda (deney grubu) 10,20 metre sürat performans ölçümlerinde, çeviklik testi ve basketbol şut testi isabet oranlarında anlamlı farklılaşma (p<0.05) olduğu bulgusuna ulaşılmıştır. Araştırma sonunda HIIT antrenman metodunun kız basketbolcularda çeviklik, dikey sıçrama ve basketbol şut testlerine olumlu etki yaptığı bulgusuna ulaşılmıştır.
Examining the relatıonship between irrational performance beliefs and sport anxiety
Authors: Toy Ali Burak , Korkmaz Cihat 
Published: October 2023

Aim: The aim of this study is to examine the relationship between irrational performance beliefs and sports anxiety.
Method: A total of 365 young amateur athletes, 108 males (29.6%) and 257 females (70.4%), with an average age of 16±54, participated in the research. "Anxiety in Sports Scale", "Irrational Performance Beliefs Inventory-2" and "Personal Information Form" created by the researcher were used to collect data in the research. The research data were analyzed using a statistical analysis program. Percentage, arithmetic mean, standard deviation and Pearson correlation test were used to evaluate the obtained data.
Findings: According to the data obtained from the research results, it was determined that the scores obtained from the irrational performance beliefs inventory and anxiety in sports scale were above the average. It has been revealed that there is a significant relationship between the total score and sub-dimensions of the anxiety scale in sports and the total score and sub-dimensions of the irrational performance beliefs scale.
Conclusion: According to the results obtained in this study, it was observed that young amateur athletes with high irrational performance beliefs also had high sports anxiety levels.
(Extended English summary is at the end of this document)
Özet
Amaç: Bu çalışmanın amacı akıldışı performans inançları ile sportif kaygı arasındaki ilişkinin incelenmesidir.
Yöntem: Araştırmaya 108 erkek (%29.6), 257 kadın (%70.4) olmak üzere yaş ortalamaları 16±54 olan toplam 365 genç amatör sporcu katılmıştır. Araştırmada veri toplamak amacıyla “Sporda Kaygı Ölçeği”, “Akıldışı Performans İnançları Envanteri-2” ve araştırmacı tarafından oluşturulan “Kişisel Bilgi Formu” kullanılmıştır. Araştırma verilerinin istatistik analiz programı kullanılarak analiz edilmiştir. Elde edilen verilerin değerlendirilmesinde yüzdelik, aritmetik ortalama, standart sapma ve Pearson korelasyon testi kullanılmıştır. Bulgular: Araştırma sonuçlarından elde edilen verilere göre akıldışı performans inançları envanteri ve Sporda kaygı ölçeğinden alınan puanların ortalamanın üstünde olduğu tespit edilmiştir. Sporda kaygı ölçeği toplam puanı ve alt boyutları ile akıldışı performans inançları ölçeği toplam puanı ve alt boyutları arasında anlamlı düzeyde bir ilişki olduğu ortaya konulmuştur. Sonuç: Bu çalışmada elde edilen sonuçlara göre yüksek akıldışı performans inançlarına sahip amatör genç sporcuların sportif kaygı düzeylerinin de yüksek olduğu görülmüştür.
Dynamical structures of wave front to the fractional generalized equal width-Burgers model via two analytic schemes: Effects of parameters and fractionality
Authors: Pervin Mst. Razia , Roshid Harun-Or- , Abdeljabbar Alrazi , Dey Pinakee , Shanta Shewli Shamim 
Published: October 2023

Abstract
This work focuses on the fractional general equal width-Burger model, which describes one-dimensional wave transmission in nonlinear Kerr media with combined dispersive and dissipative effects. The unified and a novel form of the modified Kudryashov approaches are employed in this study to investigate various analytical wave solutions of the model, considering different powers of nonlinearity in the Kerr media. As a result, a wide range of structural solutions, including trigonometric, hyperbolic, rational, and logarithmic functions, are formulated. The achieved solutions present a kink wave, a collision of kink and periodic peaked soliton, exponentially increasing wave profiles, and shock with a dark peaked wave. The obtained solutions are numerically demonstrated for specific parameter values and general parametric powers of nonlinearity. We analyzed the effect of existing parameters on the obtained wave solutions with numerical graphics. Moreover, the stability of the model is analyzed with a perturbed system. Furthermore, a comparison with published results in the literature is provided, highlighting the differences and similarities. The achieved results showcase the diversity of structural solutions obtained through the proposed approaches.
Enhanced visible-light-driven photocatalytic degradation of azo dyes by heteroatom-doped nickel tungstate nanoparticles
Authors: Alharthi Fahad A. , Albaeejan Mohammed Abdullah , Alshayiqi Alanoud Abdullah , Aldubeikl Hend Khalid , Hasan Imran 
Published: October 2023

Abstract
In this study, we conducted the hydrothermal synthesis of cobalt (Co)–doped NiWO4, resulting in the formation of Co–NiWO4 nanoparticles (NPs), followed by calcination at 550℃ for 12 h. Comprehensive analyses were performed to characterize the composition, structure, and morphology of the synthesized material. X-ray diffraction results confirmed the successful inclusion of Co in the NiWO4 lattice, with the presence of characteristic peaks of CoWO4. The crystallite size, determined using the Scherrer equation, was measured to be 22 nm. Using UV-Vis spectroscopy and Tauc’s equation, we calculated the band gap energy (E
g) to be 3.75 eV for NiWO4 and 1.75 eV for Co–NiWO4. The potential application of the synthesized material as a photocatalyst was investigated for the degradation of the diazo dye Congo red (CR). Under optimized reaction conditions, Co–NiWO4 NPs demonstrated outstanding efficiency, degrading a total of 95% of CR. The degradation kinetics were well-described by the Langmuir–Hinshelwood (L–H) kinetic model, indicating that photoabsorption played a crucial role in the rate-controlling step. These encouraging results suggest that Co–NiWO4 NPs hold promise as a viable option for addressing other pollutants in various applications.