bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical activity, sitting time, and thermal quantitative sensory testing responses in African Americans
Authors: Huber Felicitas A. , Carpenter Rachel , Goodin Burel R. , Bruehl Stephen , Karlson Cynthia , Rao Uma , Kinney Kerry , Nag Subodh , Morris Matthew C. 
Published: December 2023

Abstract

Introduction:
Prior research suggests that African Americans (AAs) have more frequent, intense, and debilitating pain and functional disability compared with non-Hispanic Whites (NHWs). Potential contributing factors to this disparity are physical activity and sedentary behavior, given that AAs are less physically active, and physical activity is associated with antinociception (whereas sedentary behavior is linked to pronociception). However, impact of these factors on pain processing has largely been unexplored in AAs, especially before chronic pain onset.

Objective:
This study examined relationships between physical activity, sedentary behavior (sitting time), and laboratory measures of pain and pain modulation in adult AAs. These included heat pain threshold and tolerance, temporal summation of pain (TSP, a marker of central sensitization), and conditioned pain modulation (CPM, a marker of descending pain inhibition).

Methods:
Multiple regressions were conducted to examine the effects of physical activity and sitting time on heat threshold and tolerance. Multilevel models were conducted to assess the relationship between physical activity, sitting time, and temporal summation of pain. Additional multilevel models were conducted to assess the relationship between physical activity, sitting time, and conditioned pain modulation.

Results:
Higher level of physical activity, but not sitting time, was associated with reduced TSP slopes. Neither physical activity nor sitting time was associated with CPM slopes. No significant relationships between physical activity or sitting time and heat pain threshold or tolerance were detected.

Conclusions:
These findings suggest that physical activity is associated with reduced TSP, an effect which may be driven by reduced spinal hyperexcitability in more active individuals. Thus, structural and individual interventions designed to increase physical activity in healthy, young AAs may be able to promote antinociceptive processes (ie, reduced TSP/reduced pain facilitation) potentially protective against chronic pain.
Different time scales used for sexual partner surveys pose a challenge in modelling dynamics of sexually transmitted infections
Authors: Murayama Hiroaki , Nishi Akihiro , Endo Akira 
Published: December 2023

AbstractMathematical models for sexually transmitted infections (STIs) are parameterised by empirical data on sexual behaviour (e.g. the number of partners over a given period) obtained from surveys. However, the time window for reporting sexual partnerships may vary between surveys and how data for different windows can be translated from one to another remains an open question. To highlight this issue, we compared the distributions of the number of sexual partners over one year and four weeks from the British National Surveys of Sexual Attitudes and Lifestyles. The results show that simple linear rescaling did not render the one-year and four-week partner distributions aligned. Parameterising STI models using survey-based sexual encounter rates without considering the implication of the reporting window used can lead to misleading results.
From solitary to colonial with zooid miniaturization: ancestral-state reconstruction based on NGS data of stolidobranch ascidians
Authors: Hasegawa Naohiro , Matsubara Shin , Shiraishi Akira , Satake Honoo , Shenkar Noa , Kajihara Hiroshi 
Published: December 2023

AbstractThe size of organisms has consistently intrigued researchers across various disciplines in biology. However, the evolutionary process of zooid miniaturization in colonial animals remained an enigmatic topic. The family Styelidae, within the ascidian order Stolidobranchia, showcases a diverse spectrum of coloniality, positioning it as an ideal candidate for delving into the intricacies of colonial evolution. In this research, we inferred a phylogenomic relationship mainly within Styelidae using transcriptomes of a total of 42 ascidians; from 17 species sampled in Israel and Japan and transcriptome data from 25 species sourced from a previous study and a database. Through ancestral-state reconstruction, our analysis indicated a clear directional change: following the acquisition of coloniality, zooids tended to become progressively smaller. This miniaturization is likely an adaptive response, enabling organisms to swiftly colonize limited marine substrate. We formulated a mathematical model suggesting that zooid miniaturization, due to living space constraints, would result in a faster asexual cycle and accelerated expansion in a colony. Our data also suggested that coloniality evolved independently three times within Styelidae. Moreover, once colonial traits are established, they appear to be consistently preserved, underscoring their biological importance in the colonial lineage.
Multi-Omics Analysis Of Antiviral Interactions OfElizabethkingia anophelisAnd Zika Virus
Authors: Omme S , Wang J , Sifuna M , Rodriguez J , Owusu NR , Goli M , Jiang P , Waziha P , Nwaiwu J , Brelsfoard CL , Vigneron A , Ciota AT , Kramer LD , Mechref Y , Onyango MG 
Published: December 2023

ABSTRACTBackgroundThe microbial communities residing in the mosquito midgut play a key role in determining the outcome of mosquito pathogen infection.Elizabethkingia anophelis, originally isolated from the midgut ofAnopheles gambiae, has drawn much attention due to its close association withAedesandAnophelesmosquitoes, primary vectors of dengue virus and malaria parasites, respectively.E. anophelispossesses a broad-spectrum antiviral phenotype, yet a gap in knowledge regarding the mechanistic basis of its interaction with viruses exists.Methodology/Principal findingsTo further understand the antiviral interactions betweenE. anophelisand Zika virus (ZIKV), we utilized a non-targeted multi-omics approach, analyzing lipids, proteins, and metabolites of cell monolayers co-infected with ZIKV andE. anophelis. We further assessed the gene expression of ZIKV when cultured in the presence ofE. anophelis. ZIKV cultured in the presence ofE. anophelisresulted in an attenuated replicative fitness and unproductive virus infection. Further, in this treatment, we observed lower levels of the nonstructural protein 5 (NS5) and RNA-directed RNA polymerase (RdRp) protein. Lastly, a significant decrease in arginine levels, an essential requirement for viral replication and progression of viral infection was observed.Conclusions/SignificanceThis study provides insights into the molecular basis ofE. anophelisantiviral phenotype. These findings improve our knowledge of how microbes and viruses interact to impact viral replication. In the future, our findings can be utilized to unravel the mechanism behind the antiviral phenotype ofE. anophelis,and this can help develop novel paradigms for viral therapeutics.AUTHOR SUMMARYZika is a re-emerging disease and is endemic in many regions of sub-Saharan Africa, Asia and Latin America. It remains a major public health threat and lacks FDA-approved therapeutics or vaccines, hence the urgent need for the identification of alternative approaches that limit the transmission of the pathogens by its primary vector,Aedesspp. The microbial communities residing in the mosquito midgut play a key role in determining the outcome of mosquito pathogen infection. Flavobacteria dominates the mosquito midgut includingElizabethkingia, which is a gram-negative bacillus prevalent inAedesandAnophelesspecies of mosquitoes.E. anophelis, a poorly studied midgut microbe, has a broad-spectrum antiviral phenotype, yet the mechanism of its antiviral action is unknown. In this study, we have identified several pathways as well as Zika virus proteins perturbed when the Zika virus is cultivated in the presence ofE. anophelis. Our findings do not only provide insights into microbial, virus interaction but could be harnessed to develop novel antiviral tools.
In silicocharacterization, homology modeling and structure-based functional annotation of Nile Tilapia (Oreochromis niloticus) Hsp70 and Hsc70 proteins
Authors: Dayrit Geraldine B. , Burigsay Normela Patricia F. , Vera Cruz Emmanuel M. , Santos Mudjekeewis D. 
Published: December 2023

AbstractBackgroundThe molecular chaperones known as heat shock proteins 70 (Hsp70) and heat shock cognate protein 70 (Hsc70) are vital for maintaining cellular integrity and controlling stress.MethodologyTheOn-Hsp70 andOn-Hsc70 proteins from Nile tilapia (Oreochromis niloticus) have been thoroughly examined in this study usingin silicoanalysis, homology modeling, and functional annotation. Homology modeling was carried out using the SWISS- MODEL program, and the proposed model was assessed for its high reliability through analyses including ProSA, Verify 3D, PROVE, ERRAT, and Ramachandran plot.ResultsThe essential features of theOn-Hsp70 andOn-Hsc70 proteins encompass amino acid lengths (640 and 645), molecular weights (70,233.48 and 70,773.17 Da), theoretical isoelectric points (pI = 5.63 and 5.28), and the overall counts of negatively and positively charged residues (95 and 86; 95 and 81). Furthermore, the instability index (II) values were 35.27 (On-Hsp70) and 38.85 (On-Hsc70). Similarly, the aliphatic index (AI) exhibited high values for both proteins, reaching 84.58 (On-Hsp70) and 82.85 (On-Hsc70).On-Hsp70 andOn-Hsc70 were both shown to contain an MreB/Mbl domain.DiscussionThe authors found thatOn-Hsp70 andOn-Hsc70 share key characteristics, including an acidic nature, high stability, and conserved domains. Protein-protein interaction analysis identified the co-chaperone Stip1 as a primary functional partner. Comparative modeling yielded highly reliable 3D models, revealing structural similarity to known proteins and predicted binding sites. Furthermore, the primary subcellular localization of both proteins is the cytoplasm. Functional analysis predicted an AMP-PNP binding site forOn-Hsp70 and ATP binding site forOn-Hsc70.ConclusionThe discoveries deepen our understanding of Hsc70 and Hsp70 in Nile tilapia, highlighting their importance in fish physiology and positioning them as crucial study topics moving forward. This study adds to our understanding of the actions of these proteins in cellular processes and stress responses, which could impact fish health and resilience.
Sensorimotor Impairment in Ageing and Neurocognitive Disorders: Beat Synchronisation and Adaptation to Tempo Changes
Authors: von Schnehen Andres , Hobeika Lise , Houot Marion , Recher Arnaud , Puisieux François , Huvent-Grelle Dominique , Samson Séverine 
Published: December 2023

ABSTRACTBackgroundUnderstanding the nature and extent of sensorimotor decline in ageing individuals and those with neurocognitive disorders NCD, such as Alzheimer’s disease, is essential for designing effective music-based interventions.ObjectiveOur understanding of rhythmic functions remains incomplete, particularly in how ageing and NCD affect sensorimotor synchronisation and adaptation to tempo changes. This study aims to fill this knowledge gap.MethodsPatients from a memory clinic participated in a tapping task, synchronising with metronomic and musical sequences, some of which contained sudden tempo changes. After exclusions, 51 patients were included in the final analysis.ResultsParticipants’ mini-mental state examination scores were associated with tapping consistency. Additionally, age negatively influenced consistency when synchronising with a musical beat, whereas consistency remained stable across age when tapping with a metronome.ConclusionsThe ability to extract a beat from a musical signal diminishes with age, whereas the capacity to maintain a beat remains relatively constant. However, both processes may decline at moderate or severe stages of NCD. Moreover, the results indicate that the initial decline of attention and working memory with age may impact perception and synchronisation to a musical beat, whereas progressive NCD-related cognitive decline results in more widespread sensorimotor decline, affecting tapping irrespective of audio type. These findings underline the importance of customising rhythm-based interventions to the needs of older adults and individuals with NCD, taking into consideration their cognitive as well as their rhythmic aptitudes.This study was registered atclinicaltrials.gov(NCT04146688).
Pupil dilation reflects effortful action invigoration in overcoming aversive Pavlovian biases
Authors: Algermissen Johannes , den Ouden Hanneke E. M. 
Published: December 2023

Abstract“Pavlovian” or “motivational” biases describe the phenomenon that the valence of prospective outcomes modulates action invigoration: Reward prospect invigorates action, while punishment prospect suppresses it. The adaptive role of these biases in decision-making is still unclear. One idea is that they constitute a fast-and-frugal decision strategy in situations characterized by high arousal, e.g., in presence of a predator, which demand a quick response. In this pre-registered study (N= 35), we tested whether such a situation—induced via subliminally presented angry vs. neutral faces—leads to increased reliance on Pavlovian biases. We measured trial-by-trial arousal by tracking pupil diameter while participants performed an orthogonalized Motivational Go/NoGo Task. Pavlovian biases were present in responses, reaction times, and even gaze, with lower gaze dispersion under aversive cues reflecting “freezing of gaze”. The subliminally presented faces did not affect responses, reaction times, or pupil diameter, suggesting that the arousal manipulation was ineffective. However, pupil dilations reflected facets of bias suppression, specifically the physical (but not cognitive) effort needed to overcome aversive inhibition: Particularly strong and sustained dilations occurred when participants managed to perform Go responses to aversive cues. Conversely, no such dilations occurred when they managed to inhibit responses to Win cues. These results suggest that pupil diameter does not reflect response conflict per se nor the inhibition of prepotent responses, but specifically effortful action invigoration as needed to overcome aversive inhibition. We discuss our results in the context of the “value of work” theory of striatal dopamine.
Sex chromosome dominance in a UV sexual system
Authors: Vigneau Jeromine , Martinho Claudia , Godfroy Olivier , Zheng Min , Haas Fabian B. , Borg Michael , Coelho Susana M. 
Published: December 2023

AbstractThe alternation between multicellular haploid gametophytes and diploid sporophytes is a defining feature of most plant and algal life cycles. In such organisms, male and female sexes are determined in the haploid gametophyte with a female (U) or male (V) sex chromosome. Once the U and V chromosomes unite at fertilisation, sex determination no longer occurs, raising key questions about the fate of UV sex chromosomes in the diploid sporophyte stage of the life cycle. Here, we unravel the genetic and molecular interactions between the U and V chromosomes by assessing transcriptional and chromatin states across the life cycle of the brown algaEctocarpusalongsideouroborosmutants that decouple life cycle stage from ploidy. We reveal how sex chromosome genes are developmentally regulated across the life cycle, with genes involved in female sex determination in particular undergoing strong down-regulation in the sporophyte. Diploidouroborosmutants containing both a U and V sex chromosome behave as functional male gametophytes yet still exhibit feminized transcription, suggesting that presence of the V chromosome alone is insufficient to fully suppress female developmental program. Although the silencing of sex chromosome genes in the diploid sporophyte does not appear to correlate with localised changes in chromatin state, small RNAs may play a role in the repression of a female sex-linked gene. Finally, we show how histone H3K79me2 is globally re-configured in the diploid phase of the life cycle, including the sex determining region of the UV sex chromosomes. Contrary to its pattern in the haploid gametophyte, H3K79me2 no longer associates with repressed genes in the diploid sporophyte, suggesting that the function of this histone mark inEctocarpusmay be more complex than previously appreciated.
The role of big data in the formation of supply chain platform for new forms of online retail
Authors: Bai Bingfeng , Wu Guohua 
Published: December 2023

PurposeThe purpose of this study is to explore the relationship between big data and supply chain platform in China’s retail industry. With the emergence of big data resources and technologies, the business pattern of new retail advocates the combination of online and offline channels. Supply chain platform plays a key role in the implementation of retail activities, which has gradually become a research hotspot in the cross field of operations management and information system.Design/methodology/approachThrough the method of literature review and case study, this study empirically explores how big data shapes supply chain platform to support new forms of online retail by grounded theory.FindingsThe model framework is validated by reliability test and coding method to process survey materials. The results identify the overall antecedents of supply chain platform and reveal positive effects between big data and new retail. The findings help firm managers build a big data-driven supply chain to support new retail.Originality/valueThere are insufficient studies on theoretical frameworks and interaction relationships among big data, supply chain platform and new retail.
Mental health issues of university librarians: a systematic literature review
Authors: Shahzad Khurram , Khan Shakeel Ahmad , Iqbal Abid 
Published: December 2023

Purpose
This study aims to identify the causes of mental health issues faced by university librarians, to investigate the impact of mental health issues on the job performance of university librarians, and to know about the health activities to maintain mental and physical health.

Design/methodology/approach
The systematic literature review was applied as the research methodology. Forty-three research papers published in peer-reviewed journals were selected to conduct the study.

Findings
The findings of the study revealed that several factors including socio-economic conditions, work stress, stigma, constant fear, lack of self-efficacy, negative thinking, job security problems, strict organizational climate, poor human relations, lack of required job skills, chronic diseases and global pandemics cause mental problems in library professionals. Mental health issues have a negative impact on the job output of librarians. Different activities including emotional health training sessions, physical and mental exercises, social connections, membership of mental health centres, continuing professional development, and self-care training assist in the stability of the physical and mental fitness of librarians.

Originality/value
The study has a societal impact through the identification of different activities for maintaining mental health. It has offered theoretical implications for the investigators to further conduct studies in the area of mental health and librarians. It has also provided managerial implications for management bodies to take fruitful measures for the sound mental health of librarians so that they might carry out innovative library services.
A comparison of the importance of wine supplier quality attributes for on-premise and off-premise wine retail establishments
Authors: Moon Chanwoo , Bonn Mark A. , Cho Meehee 
Published: December 2023

Purpose
Given the intensified competitiveness in the wine retail industry, partnering with quality suppliers becomes critical to ensure a steady supply of high-quality products and sustainable business growth. This study aims to explore how wine supplier quality attributes impact wine retail businesses and if such effects differ depending on wine retail types.

Design/methodology/approach
Data were obtained from wine purchasing managers in Korea. To validate the proposed relationships, structural equation modeling was used. A multigroup analysis was conducted to test distinct roles of on/off-premise wine retail types within this research framework.

Findings
Results support the significance of supplier quality attributes in shaping the landscape of wine retail businesses. Operational and strategic benefits exhibited a positive effect on both financial performance and suppliers’ relationship satisfaction, thereby improving the intent to continue working with suppliers. This study revealed noteworthy distinctions in the effects of supplier quality attributes on operational and strategic benefits between on-premise and off-premise wine retailers.

Research limitations/implications
Findings provide valuable insights to wine suppliers and buyers concerning the establishment of a mutually beneficial long-term interdependent relationship. The approach sheds light on the unique dynamics of wine retail types, contributing to a more comprehensive understanding of the distinct roles of supplier quality attributes on on-premise and off-premise retailers.

Originality/value
This study developed an integrative framework, emphasizing the importance of supplier quality attributes in the wine retail industry. This model offers valuable insights into creating favorable buyer–supplier relationships that result in mutual benefits for both wine retailers and suppliers.
Conceptualising accounting as a value-based concept in the context of alternative finance
Authors: Alamad Samir 
Published: December 2023

PurposeThis study aims to investigate the claim that there is no coherent and homogeneous body of concepts and practices that can be classified as “Islamic accounting”.Design/methodology/approachThe study focuses specifically on Islamic accounting and uses a qualitative historical documentary analysis methodology to study an original manuscript from the 14th century.FindingsThe analysis of the manuscript argues that religious accounting can be seen as a value-based system for achieving social good and that in the context of Islamic accounting, it can be conceptualised as a coherent body of ideas and practices.Originality/valueFirstly, the study conceptualises Islamic accounting as a homogeneous discipline with its own knowledge, concepts and practices. Secondly, it contributes to current accounting literature by examining an ancient manuscript from the 14th century, which serves as a foundation for understanding the Islamic accounting system within the context of accounting, religion and spirituality. The paper further contributes by arguing that this conceptualisation of religious accounting as a value-based approach enables its practitioners to evaluate their own accountabilities in delivering on socioeconomic objectives related to inter-human/environmental, social and financial transactions within the context of religious accounting practices.