bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative electroencephalography predicts postoperative delirium in cardiac surgical patients after cardiopulmonary bypass: a prospective observational study
Authors: Xue Yuechuan , Liu Wanglin , Su Longxiang , He Huaiwu , Chen Huan , Long Yun 
Published: October 2023

ObjectiveDespite its frequency and associated negative effect, delirium remains poorly recognized in postoperative patients after ICU admission, especially among those who have undergone cardiac surgery with cardiopulmonary bypass. Postoperative delirium is triggered by a wide variety of acute medical conditions associated with impaired neuronal network connectivity. The lack of objective biomarkers primarily hinders the early detection of delirium. Seeking early biomarkers for tracking POD could potentially assist in predicting the onset of delirium and assessing the severity of delirium and response to interventions.MethodsQEEGs were taken from 46 sedated postoperative patients, with 24 of them having undergone cardiac surgery. The assessment of delirium was performed twice daily using the Confusion Assessment Method for the ICU (CAM-ICU) to screen for postoperative delirium (POD). QEEG data were interpreted clinically by neurophysiologists and processed by open-source EEGLAB to identify features in patients who had or did not have POD after cardiac or non-cardiac surgery.ResultsThe incidence of delirium in patients after undergoing cardiac surgery was nine times greater than in those after non-cardiac surgeries (41.7% vs. 4.5%; p = 0.0046). Patients with delirium experienced longer use of mechanical ventilation (118 h (78,323) compared to 20 h (18,23); p &lt; 0.0001) and an extended ICU length of stay (7 days (6, 20) vs. 2 days (2, 4); p &lt; 0.0001). The depth of anesthesia, as measured by RASS scores (p = 0.3114) and spectral entropy (p = 0.1504), showed no significant difference. However, notable differences were observed between delirious and non-delirious patients in terms of the amplitude-integrated EEG (aEEG) upper limit, the relative power of the delta band, and spectral edge frequency 95 (SEF95) (p = 0.0464, p = 0.0417, p = 0.0337, respectively).ConclusionIn a homogenous population of sedated postoperative patients, robust qEEG parameters strongly correlate with delirium and could serve as valuable biomarkers for early detection of delirium and assist in clinical decision-making.
Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort
Authors: Pérez-Jeldres Tamara , Magne Fabien , Ascui Gabriel , Alvares Danilo , Orellana Matias , Alvarez-Lobos Manuel , Hernandez-Rocha Cristian , Azocar Lorena , Aguilar Nataly , Espino Alberto , Estela Ricardo , Escobar Sergio , Zazueta Alejandra , Baez Pablo , Silva Verónica , De La Vega Andres , Arriagada Elizabeth , Pavez-Ovalle Carolina , Díaz-Asencio Alejandro , Travisany Dante , Miquel Juan Francisco , Villablanca Eduardo J. , Kronenberg Mitchell , Bustamante María Leonor 
Published: October 2023

Background and aimsLatin American populations remain underrepresented in genetic studies of inflammatory bowel diseases (IBDs). Most genetic association studies of IBD rely on Caucasian, African, and Asian individuals. These associations have yet to be evaluated in detail in the Andean region of South America. We explored the contribution of IBD-reported genetic risk variants to a Chilean cohort and the ancestry contribution to IBD in this cohort.MethodsA total of 192 Chilean IBD patients were genotyped using Illumina's Global Screening Array. Genotype data were combined with similar information from 3,147 Chilean controls. The proportions of Aymara, African, European, and Mapuche ancestries were estimated using the software ADMIXTURE. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for gender, age, and ancestry proportions. We also explored associations with previously reported IBD-risk variants independently and in conjunction with genetic ancestry.ResultsThe first and third quartiles of the proportion of Mapuche ancestry in IBD patients were 24.7 and 34.2%, respectively, and the corresponding OR was 2.30 (95%CI 1.52–3.48) for the lowest vs. the highest group. Only one variant (rs7210086) of the 180 reported IBD-risk SNPs was associated with IBD risk in the Chilean cohort (adjusted P = 0.01). This variant is related to myeloid cells.ConclusionThe type and proportion of Native American ancestry in Chileans seem to be associated with IBD risk. Variants associated with IBD risk in this Andean region were related to myeloid cells and the innate immune response.
Adequacy of iodized salt and its associated factors among households in the Bahir Dar Zuria district, Northwest Ethiopia, 2022
Authors: Temech Emebet Chalachew , Said Oumer , Endalik Genete , Demilew Yeshalem Mulugeta , Belay Mahider Awoke , Kassie Tadele Derbew , Dessie Anteneh Mengist 
Published: October 2023

BackgroundThe inadequacy of iodine in salt is the a contributing factor behind lack of awareness and poor economic performance in developing countries. To address the issue of iodine deficiency, universal salt iodization has been implemented globally. Nevertheless, it is imperative to closely monitor the sufficiency of iodine in salts to achieve its intended objective at the household level in the Bahir Dar Zuria district.ObjectiveTo assess the adequacy of iodized salt and its associated factors among households in the Bahir Dar Zuria district, Northwest Ethiopia.MethodsA community-based cross-sectional study was conducted from May to June 2022 among households in Bahir Dar Zuria district. The data were gathered from 825 households that were chosen using a multistage sampling process. Iodometric titration was used to assess the amount of iodine in salt. The data were gathered using a structured questionnaire that was administered by an interviewer. For data entry and analysis, EpiData version 3.01 and SPSS version 25.0 were used, respectively. To evaluate the association between explanatory factors and the outcome variable, binary logistic regression was conducted, and significance was determined at alpha 0.05.ResultThis study analyzed a total of 825 households. Of these, only 384 [46.5, 95% CI, 43.5–50.5%] households had adequately iodized salt at home. Age increase of 1 year [AOR = 1.04, 95% CI = 1.02–1.06], being an urban resident [AOR = 3.18, 95% CI = 1.84–5.48], diploma and above educational attainment [AOR = 3.74, 95% CI = 1.99–7.02], checking salt by asking the seller [AOR = 2.21, 95% CI = 1.26–3.88], storing salts in closed containers [AOR = 1.57, 95% CI = 1.13–2.19], and storing salts in a dry and cool area [AOR = 2.72, 95% CI =1.37–5.42] were associated with the adequacy of iodized salt at the household level.Conclusion and recommendationThe percentage of households in the district (46.5%) that had enough iodized salt in their homes is still extremely low and falls short of the targeted level for the country. At the household level, adequate iodized salt was found to be associated with age, place of residence, level of education, checking salt iodization while purchasing, place of salt storage, and cover use for salt containers. Therefore, increasing the accessibility of iodized salt at the household level is essential.
Treatment-Resistant Depression in America Latina study: one-year follow-up of treatment resistant depression patients under standard of care reveals insights on quality of life, disability, work impairment, and depressive symptoms
Authors: Recco Kelen , Bonetto Gerardo Garcia , Lupo Christian , Nardi Antonio E. , Morales Arnulfo , Becerra-Palars Claudia , Perocco Sergio , Pfau Alanna 
Published: October 2023

IntroductionDepressive Disorders are on the rise worldwide. This is also the case in Latin America (LatAm). Treatment-Resistant Depressive Disorder (TRD) poses additional burden to patients with depression. Impacts quality of life (QoL) and other dimensions, and standard of care (SOC) is insufficient to achieve the desired clinical outcomes. Evidence from LatAm is, however, lacking. The present study was devised as a 1-year follow-up of the SOC in TRD patients in LatAm to explore the burden of TRD.MethodsThis was an observational, multinational, longitudinal study. Patients with clinical diagnosis of TRD in LatAm were included in a 1-year follow-up with SOC. Beyond the Sociodemographic characterization, outcome measures were QoL (EQ-5D-5L), disability (Sheehan Disability Scale - SDS), work productivity (Work Productivity and Activity Incapacity Questionnaire: depression - WPAI:D) and depression severity (Patient Health Questionnaire-PHQ9). Patients were assessed every 3-months and comparison was performed based on change from baseline to each visit and end of study (EOS - 12 months).ResultsPatients averaged 48 (± 13.12) years, mostly female (80.9%) and married/consensual union (42.5%) or single patients (34.4%). Despite the SOC treatment, three-quarters of the patients remained symptomatic at EOS, regardless of the significant longitudinal decrease (p ≤ 0.001). Similar trends were found for disability (p ≤ 0.001) -82.2% of the patients reporting work/school disruption at EOS-, percentage of work (34%) and activity impairment (40%) at EOS (p ≤ 0.001) and only 29.2% of patients with depressive severity “none” at EOS (p ≤ 0.001). The results portray the need to improve clinical outcomes in this complex and burdensome disease in LatAm.DiscussionHere we show that the burden of TRD remains significant in essential dimensions of everyday life at EOS underlining the need for better therapeutic solutions. The improvements in most patients do not provide the desired outcome of return to the state before the condition. Further research should focus on identifying which treatments provide better outcomes in a real-world context.
Prevalence and impact of long COVID-19 among patients with diabetes and cardiovascular diseases in Bangladesh
Authors: Sharif Nadim , Sharif Nazmul , Khan Afsana , Halawani Ibrahim F. , Alzahrani Fuad M. , Alzahrani Khalid J. , Díez Isabel De la Torre , Vargas Debora Libertad Ramírez , Castilla Angel Gabriel Kuc , Parvez Anowar Khasru , Dey Shuvra Kanti 
Published: October 2023

IntroductionCo-prevalence of long-COVID-19, cardiovascular diseases and diabetes is one of the major health challenges of the pandemic worldwide. Studies on long-COVID-19 and associated health outcomes are absent in Bangladesh. The main aim of this study was to determine the prevalence and impact of long-COVID-19 on preexisting diabetes and cardiovascular diseases (CVD) on health outcomes among patients in Bangladesh.MethodsWe collected data from 3,250 participants in Bangladesh, retrospectively. Multivariable logistic regression model was used to determine the odds ratio between independent and dependent variables. Kaplan-Meier survival curve was used to determine the cumulative survival.ResultsCOVID-19 was detected among 73.4% (2,385 of 3,250) participants. Acute long-COVID-19 was detected among 28.4% (678 of 2,385) and chronic long-COVID-19 among 71.6% (1,707 of 2,385) patients. CVD and diabetes were found among 32%, and 24% patients, respectively. Mortality rate was 18% (585 of 3,250) among the participants. Co-prevalence of CVD, diabetes and COVID-19 was involved in majority of fatality (95%). Fever (97%), dry cough (87%) and loss of taste and smell (85%) were the most prevalent symptoms. Patients with co-prevalence of CVD, diabetes and COVID-19 had higher risk of fatality (OR: 3.65, 95% CI, 2.79–4.24). Co-prevalence of CVD, diabetes and chronic long-COVID-19 were detected among 11.9% patients.DiscussionRisk of hospitalization and fatality reduced significantly among the vaccinated. This is one of the early studies on long-COVID-19 in Bangladesh.
Multimodal deep learning for liver cancer applications: a scoping review
Authors: Siam Aisha , Alsaify Abdel Rahman , Mohammad Bushra , Biswas Md. Rafiul , Ali Hazrat , Shah Zubair 
Published: October 2023

BackgroundHepatocellular carcinoma is a malignant neoplasm of the liver and a leading cause of cancer-related deaths worldwide. The multimodal data combines several modalities, such as medical images, clinical parameters, and electronic health record (EHR) reports, from diverse sources to accomplish the diagnosis of liver cancer. The introduction of deep learning models with multimodal data can enhance the diagnosis and improve physicians' decision-making for cancer patients.ObjectiveThis scoping review explores the use of multimodal deep learning techniques (i.e., combining medical images and EHR data) in diagnosing and prognosis of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA).MethodologyA comprehensive literature search was conducted in six databases along with forward and backward references list checking of the included studies. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension for scoping review guidelines were followed for the study selection process. The data was extracted and synthesized from the included studies through thematic analysis.ResultsTen studies were included in this review. These studies utilized multimodal deep learning to predict and diagnose hepatocellular carcinoma (HCC), but no studies examined cholangiocarcinoma (CCA). Four imaging modalities (CT, MRI, WSI, and DSA) and 51 unique EHR records (clinical parameters and biomarkers) were used in these studies. The most frequently used medical imaging modalities were CT scans followed by MRI, whereas the most common EHR parameters used were age, gender, alpha-fetoprotein AFP, albumin, coagulation factors, and bilirubin. Ten unique deep-learning techniques were applied to both EHR modalities and imaging modalities for two main purposes, prediction and diagnosis.ConclusionThe use of multimodal data and deep learning techniques can help in the diagnosis and prediction of HCC. However, there is a limited number of works and available datasets for liver cancer, thus limiting the overall advancements of AI for liver cancer applications. Hence, more research should be undertaken to explore further the potential of multimodal deep learning in liver cancer applications.
New insights from Norwegian and Swedish sports coaches' employment, practices, and beliefs during the first COVID-19 restriction period
Authors: Severin Anna Cecilia , Skovereng Knut , Björklund Glenn , Hemmestad Liv , Sandbakk Øyvind , Bucher Sandbakk Silvana 
Published: October 2023

IntroductionThis study (i) examined Norwegian and Swedish sports coaches' employment, practices, and beliefs during the first wave of the COVID-19 pandemic, (ii) compared these aspects between coaches in Norway and Sweden, two countries with clearly different movement restrictions strategies in this period.MethodsAn online survey was distributed to coaches via email and social media. The survey was open between June and August 2020. In total, 348 coaches responded, 141 from Norway, and 207 from Sweden.ResultsAmong responders, 2% had lost their job due to the pandemic, 17% had been furloughed, 28% worked from home office, and 39% worked as usual. Norwegian coaches were more likely to work from home (48% vs. 15%, p &lt; .001), while Swedish coaches were more likely to work as usual (60% vs. 9%, p &lt; .001). Coaches in both countries communicated less frequently with their athletes (p &lt; .001) and had less in-person communication (p &lt; .001) compared to pre-Covid levels. Larger declines existed among Norwegian coaches regarding communication frequency (p &lt; .001) and in-person communication (p &lt; .001). Video calls and phone calls usage increased (p &lt; .001 and p = .009 respectively). We recorded low levels of concern among coaches about the effects of the pandemic on their relationship with their athletes. There were considerable levels of concern about athletes’ maintaining their motivation to train (Norway: 43.3%, Sweden: 50.7%), and low levels of concern about the coaches’ relationships with their athletes (Norway: 14.1%, Sweden: 17.8%).DiscussionOverall, this study showed the imposed movement restrictions had several negative consequences for the employment and work practices of sports coaches in Norway and Sweden. However, it also highlighted that coaches were able to adapt their work practices to the constraints and were able to maintain relationships with their athletes. The consequences raised in this paper can act as a guide during possible future lockdowns.
Análise da influência do sulfato de gentamicina e técnica de resfriamento nas propriedades mecânicas do poli (metacrilato de metila)
Authors: Cardoso Pedro Henrique Novaes , Baraúna Júnior Durval , Fonseca Kaio Luan da Silva , Cordeiro Erlon Rabelo , Idogava Henrique Takashi , Da Silva Alan Christie , Hernandez Luis Iván Negrin , Olivier Nelson Cárdenas 
Published: October 2023

O Poli(metacrilato de metila) é um polímero largamente utilizado nas mais diversas aplicações da biomedicina. Na ortopedia, este polímero pode ser utilizado como reforço estrutural em fraturas ósseas, e com isso, garante a integridade física do osso danificado. Com o intuito de evitar a proliferação de micróbios na fratura, uma determinada quantidade de antimicrobiano pode ser adicionada homogeneamente ao Poli(metacrilato de metila). Para prevenir a necrose térmica durante a polimerização, que pode atingir até 100°C, utiliza-se técnicas de resfriamento, garantindo a temperatura ideal de preservação da integridade das células na região da fratura. Este trabalho teve como objetivo avaliar a influência da adição de Sulfato de Gentamicina e aplicação de técnica de resfriamento no comportamento mecânico do Poli(metacrilato de metila) comercializado em três tipos de nomenclaturas comerciais. Para isso, foi utilizada a Microscopia Eletrônica de Varredura, e os ensaios mecânicos de compressão, flexão e torção. Com estes ensaios, foi possível constatar que o Poli(metacrilato de metila), após ser submetido a técnica de resfriamento e a adição de antimicrobiano, ainda atende os requisitos de resistência mecânica exigidos por normas técnicas que especificam o uso deste material em aplicações ortopédicas, garantindo o uso com segurança para esta aplicabilidade.
PENENTUAN DESAIN INSTALASI PENGOLAHAN AIR DI MUARA RENGAS
Authors: Sefentry Aan , Bakrie M. , Firdaus Muhammad , Faruki Rut , Hardiyanti Kiki , Lelawati Lelawati 
Published: October 2023

Air bersih di daerah Kecamatan Muara Lakitan terutama Desa Muara Rengas dengan jumlah penduduk 12,723 jiwa (tahun 2019) merupakan salah satu kebutuhan pokok. Tujuan dari penelitian ini dapat memprediksi pertumbuhan penduduk dihubungkan kebutuhan akan air bersih sampai tahun proyeksi 2029 di daerah Muara Lakitan, mengetahui kapasitas instalasi pengolahan air (IPA) di yang akan direncanakan dan menentukan desain instalasi pengolahan air (IPA). Adapun prosedur penelitian dengan mengumpulan data dan koordinasi yang diperlukan dengan aparat setempat lalu survey lokasi penelitian guna mendapatkan gambaran umum daerah studi dan kondisi eksisting juga manyajikan kondisi sistem dan perhitungan kebutuhan air minum untuk daerah pelayanan dan melakukan survey lapangan dengan menggunakan GPS pada unit transmisi, dan sistem distribusi air minum dengan Sistem Pembangunan Instalasi Pengolahan Air (IPA), juga melakukanan analisa kebutuhan air minum domestik dan non domestik dan akhirnya melakukan penggambaran teknis sistem penyediaan air minum baik yang sifatnya tipikal/estándar maupun spesifik sesuai kondisi di lapangan sehingga didapat kapasitas Instalasi Pengolahan Air sebesar 30 liter/detik.
Kata kunci : Instalasi Pengolahan Air (IPA); Global Positioning System (GPS).
IDENTIFIKASI MUTU BATA BETON PEJAL DI WILAYAH KABUPATEN MANOKWARI
Authors: Tethool Yoga Charol Vincenthius , Birawaputra Indra 
Published: October 2023

Kabupaten Manokwari terletak pada lokasi rawan gempa bumi mengharuskan setiap gedung yang dibangun di wilayah ini memenuhi persyaratan teknis yang berlaku. Salah satu elemen dari bangunan gedung bertingkat rendah yang memiliki peranan penting dalam mereduksi beban gempa adalah dinding. Bata beton pejal atau batako merupakan material inti penyusun elemen dinding. Seiring dengan pembangunan yang sedang dilakukan saat ini, maka permintaan material batako menjadi meningkat di wilayah Kabupaten Manokwari. Penelitian ini bertujuan untuk mengetahui kesesuaian kualitas bata beton pejal (batako) yang ada di pasaran Kabupaten Manokwari dengan standar yang berlaku. Hasil pengamatan terhadap pandangan luar terhadap permukaan sampel batako diperoleh hasil bahwa kelompok sampel III tidak memenuhi syarat. Hasil pengamatan terhadap kondisi rusuk sampel diperoleh hasil semua kelompok sampel masih memenuhi syarat, sedangkan pengujian rusuk sampel yang mudah dihancurkan dengan tangan diketahui bahwa kelompok sampel I memiliki kondisi yang tidak memenuhi persyaratan. Hasil pengujian dimensi bata beton pejal menunjukan bahwa secara rata-rata ukuran bata beton pejal yang ada di pasaran Kabupaten Manokwari berukuran panjang 264.2 mm, lebar 128.95 mm dan tebal 69.18 mm. Hal ini masih belum memenuhi persyaratan ukuran dalam SNI 03-0349-1989. Hasil pengujian penyerapan air menunjukan bahwa semua kelompok sampel tergolong dalam tingkatan mutu I (kurang dari 25%). Pengujian kuat tekan dari kelompok sampel I, II, III, IV dan V berturut-turut sebesar 3.58 kg/cm2, 14.04 kg/cm2, 10.04 kg/cm2, 11.24 kg/cm2, 8.47 kg/cm2.Hasil ini menunjukan bahwa semua kelompok sampel belum memenuhi persyaratan kuat tekan minimal untuk tingkatan mutu IV.
Kata kunci : batako, bata beton pejal, uji tekan, SNI 03-0349-1989
Mutu fillet ikan nila (Oreochromis niloticus) pada fase post mortem dengan pengawet dari ekstrak biji picung (Pangium edule Reinw) pada penyimpanan suhu dingin
Authors: Munandar Aris , Febrisari Yanti , Haryati Sakinah , Surilayani Dini 
Published: October 2023

Tilapia fillets are produced to be easier to process and are expected to increase fish consumption. Tilapia fillets with the addition of 60% picung seed extract had a post-mortem phase of 13 days. Picung seeds serve as preservatives because they contain antibacterial alkaloids, flavonoids, and tannins. Therefore, the quality of tilapia fillets with the addition of 60% picung seed extract needs to be studied. This study aimed to determine the quality of tilapia fillets during the post-mortem phase. ilapia fillets soaked in picung seed extract 60% for 30 minutes and stored at cold temperatures. Tilapia fillet quality parameters include pH, Total Plate Count (TPC), Total Volatile Base (TVB), and organoleptic Test (appearance, smell, and texture). Observations were conducted in the pre-rigor phase (1st day), rigor mortis (6th day), early post-rigor (10th day), and late (13th day). Data analysis was done by complete randomized design. The pH of the tilapia fillet in the pre-rigor to post-rigor phase is 6.34-6.45. The value indicates that the fillet is still of good quality. Based on TPC and TVB values, tilapia fillets have good quality until the sixth day (rigor mortis). TPC value in that phase is smaller than 5 x 10-5, 1.54 x 10-4 colonies/mL, while the TVB value is 22.24 mg N/100 g smaller than the standard (30 mg N/100 g). The parameters of appearance, smell, and texture have a value of more than 7 in the rigor mortis phase. The organoleptic value showed that tilapia fillets were of good quality until the rigor mortis phase for six days. Tilapia fillets have good quality until the rigor mortis phase based on SNI 2729: 2013). Such tilapia fillets have a shelf life and can be consumed until the sixth day.