bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CalculAuthor: determining authorship using a simple-to-use, fair, objective, and transparent process
Authors: Martins Russell Seth , Mustafa Mohsin Ali , Fatimi Asad Saulat , Nasir Nosheen , Pervez Alina , Nadeem Sarah 
Published: November 2023

AbstractAuthorship determination on a research article remains a largely subjective process. Existing guidelines on authorship taxonomy lack objectivity and are more useful in determining who deserves authorship rather than determining the order of authors. To promote best practices in authorship taxonomy, we developed an authorship rubric that provides a fair, objective, and transparent means of crediting authorship. We christened this tool the “CalculAuthor”. The following steps are to be undertaken to create a scoring system based on the requirements of the projects: determining creditable criteria, assigning credit weightages, deciding levels of contribution, determining each author’s contribution, calculating authorship scores and ranking. These must be performed by or in close collaboration with the primary investigator (PI), with conflicts being resolved at the PI’s discretion. All team members should be informed about the authorship determination process early in the project and their agreement regarding its use must be obtained. While the CalculAuthor was developed to be used in medical research, its customizability enables it to be employed in any field of academia. We recommend that the CalculAuthor be piloted within institutions before its mainstream adoption, and any institution-specific factors should be considered to make the process more efficient and suitable.
Comprehensive analysis of aero-engine vibration signals based on wavelet transform method
Authors: Xin Mai , Ye Zhifeng , Zhao Yu , Liu Xing , Liu Longlong , Ge Hailang , Zhang Tong 
Published: November 2023

AbstractA single type of signal processing means that it is difficult to analyze vibration signals comprehensively and effectively. By comprehensively using wavelet analysis techniques, a comprehensive and in-depth study of aero-engine vibration conditions is realized as a way to carry out health management. By introducing various types of wavelet analysis techniques and using Labview2022 programming, corresponding signal processing tools are developed for the analysis of the collected vibration signals. The comprehensive analysis of aero-engine vibration signals based on the wavelet transform method is realized, and the corresponding products are successfully applied in engineering practice.
Effects of metformin therapy on HMGB1 levels in rheumatoid arthritis patients
Authors: Zhang Lihua , Zhou Yuqing , Jiang Shengzhi , Fan Yubei , Huang Jierou , Xiao Bin , Rao Hui , Huang Lingyun 
Published: November 2023

AbstractObjectiveThe traditional treatment of rheumatoid arthritis (RA) has some side effects. We aimed to explore the effect of metformin treatment on the expression of HMGB1, cytokines, T cell subtypes and the clinical outcomes in RA patients.MethodsThe present prospective cohort study recruited 124 RA patients (metformin group) who were treated with metformin and conventional therapy (methotrexate, hydroxychloroquine sulfate and sulfasalazine) and 98 RA patients (conventional therapy group) who were only treated with conventional therapy. All subjects were admitted from December 2018 to December 2021 and continuous medication for 90 days. The serum high mobility group box 1 (HMGB1), tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-1β and C-reactive protein (CRP) levels were measured by enzyme-linked immunosorbent assay (ELISA). Flow cytometric were used to analyze the expression of CD4+and CD8+. Demographic and clinical statistics including age, body mass index (BMI), sex, course of disease, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), visual analogue score (VAS)and disease activity score (DAS)-28 were collected.ResultsThe serum levels of HMGB1, CRP, IL-6, CD4+ expression and CD4+/CD8+ ratio were significantly increased in patients with DAS-28 score ≥ 2.6. The serum HMGB1 and cytokines levels of metformin group declined more quickly during the study time. Pearson’s analysis supported that a positive correlation existed between the HMGB1 and IL-6, TNF-α, CRP, CD4+, CD4+/CD8+ratio, and VAS scores. HMGB1 could be a potential diagnostic biomarker for RA patients in active phase. Serum HMGB1 (95% CI 1.133–1.397,P < 0.001) was a factor associated with active RA.ConclusionThe serum HMGB1 levels were significantly increased in RA patients in active phase. The serum levels of HMGB1 and inflammatory factors and VAS scores were decreased gradually with metformin treatment. HMGB1 might act as a novel therapeutic target for RA.
A student-centered approach using modern technologies in distance learning: a systematic review of the literature
Authors: Kerimbayev Nurassyl , Umirzakova Zhanat , Shadiev Rustam , Jotsov Vladimir 
Published: November 2023

AbstractA literature review was conducted to develop a clear understanding of the student-centered approach using modern technologies in distance learning. The study aimed to address four research questions: What research experience already exists in the field of the student-centered approach in distance learning? What modern technologies are used in distance learning, and how are they related to the student-centered approach? What are the advantages and limitations of implementing the student-centered approach and modern technologies in distance learning? What recommendations can be derived from existing research for the effective implementation of the student-centered approach and modern technologies in distance learning? The purpose of writing this review article is to provide a comprehensive overview of the student-centered approach using modern technologies in distance learning and its advantages. To conduct this review, a Web of Science and Scopus database was searched using the keywords “student-centered approach,“ “modern technologies,“ and “distance learning.“ The search was limited to articles published between 2012 and 2023. A total of 688 articles were found, which were selected based on their relevance to the topic. After the verification and selection process, 43 articles were included in this review. The main results of the review revealed that the student-centered approach to learning took various forms or was defined individually, and there were significant differences in the main research findings. The review results provide a comprehensive overview of existing studies, advantages and limitations of the student-centered approach using modern technologies in distance learning as well as examples of successful implementation in various educational institutions. The article also discusses the challenges that online and distance learning may pose to the student-centered approach, the modern technologies that support the student-centered approach, and suggests ways to overcome these challenges. The role of technology in facilitating the student-centered approach in online and distance learning is analyzed in the article, along with recommendations and best practices for its implementation. The student-centered approach is gaining increasing attention and popularity as a means to address these issues and improve the quality of online and distance learning.
Nanomaterials-incorporated hydrogels for 3D bioprinting technology
Authors: Yoon Jungbin , Han Hohyeon , Jang Jinah 
Published: November 2023

AbstractIn the field of tissue engineering and regenerative medicine, various hydrogels derived from the extracellular matrix have been utilized for creating engineered tissues and implantable scaffolds. While these hydrogels hold immense promise in the healthcare landscape, conventional bioinks based on ECM hydrogels face several challenges, particularly in terms of lacking the necessary mechanical properties required for 3D bioprinting process. To address these limitations, researchers are actively exploring novel nanomaterial-reinforced ECM hydrogels for both mechanical and functional aspects. In this review, we focused on discussing recent advancements in the fabrication of engineered tissues and monitoring systems using nanobioinks and nanomaterials via 3D bioprinting technology. We highlighted the synergistic benefits of combining numerous nanomaterials into ECM hydrogels and imposing geometrical effects by 3D bioprinting technology. Furthermore, we also elaborated on critical issues remaining at the moment, such as the inhomogeneous dispersion of nanomaterials and consequent technical and practical issues, in the fabrication of complex 3D structures with nanobioinks and nanomaterials. Finally, we elaborated on plausible outlooks for facilitating the use of nanomaterials in biofabrication and advancing the function of engineered tissues.
A curation for uncontaminated Hayabusa2-returned samples in the extraterrestrial curation center of JAXA: from the beginning to present day
Authors: Yada Toru , Abe Masanao , Nishimura Masahiro , Sawada Hirotaka , Okazaki Ryuji , Takano Yoshinori , Sakamoto Kanako , Okada Tatsuaki , Nakato Aiko , Yoshitake Miwa , Nakano Yuki , Yogata Kasumi , Miyazaki Akiko , Furuya Shizuho , Iwamae Ayako S. , Nakatsubo Shunichi , Hatakeda Kentaro , Hitomi Yuya , Kumagai Kazuya , Suzuki Shino , Miura Yayoi N. , Ito Motoo , Tomioka Naotaka , Uesugi Masayuki , Karouji Yuzuru , Uesugi Kentaro , Shirai Naoki , Yamaguchi Akira , Imae Naoya , Naraoka Hiroshi , Yamamoto Yuhji , Tachibana Shogo , Yurimoto Hisayoshi , Usui Tomohiro 
Published: November 2023

AbstractDeveloping a cleanroom and clean chambers (CCs) for Hayabusa2 returned samples has been discussed with the committee for Hayabusa2 sample curation facility since 2015. One major difference from the specifications of the CCs used for Itokawa samples is that a part of samples was decided to be handled and preserved in vacuum to avoid terrestrial nitrogen contamination with organics or unknown materials that might easily react with the samples. Thus, the CCs for Hayabusa2 samples were divided into two CCs for vacuum processes and three CCs for purified nitrogen conditions. The cleanroom was built in summer 2017, while the CCs were installed in the summer of 2018. After the installation of the CCs, instruments for initial descriptions, sample containers, handling tools for powder and particle samples, and jigs to assist handling samples were developed in parallel with functional checks and repeated rehearsals between the fall of 2018 and the fall of 2020. The curatorial works on Hayabusa2-retuned samples were conducted as previously planned. Simultaneously, contaminations and influences of inorganics, organics, microbial, and magnetic constructs have been assessed to evaluate their potential effects on the analysis of the returned samples. Additionally, the tools used to touch samples directly have been demagnetized to avoid sample magnetization during their handling and the tool magnetization was measured before and after their usages. The series of developments and experiences from the curatorial works of Hayabusa2-returned samples represent valuable implications for future sample return missions.
Graphical Abstract
A new tibial insert design with ball‐in‐socket medial conformity and posterior cruciate ligament retention closely restores native knee tibial rotation after unrestricted kinematic alignment
Authors: Elorza Saúl Pacheco , O’Donnell Ed , Nedopil Alexander J. , Howell Stephen M. , Hull Maury L. 
Published: November 2023

AbstractPurposeIn total knee arthroplasty (TKA) with posterior cruciate ligament (PCL) retention, the medial and lateral insert conformity that restores in vivo native (i.e., healthy) knee tibial rotation and high function without causing stiffness is unknown. The purpose was to determine whether a ball‐in‐socket (B‐in‐S) medially conforming (MC) and flat lateral insert implanted with unrestricted kinematic alignment (KA) TKA and PCL retention restores tibial rotation to native.MethodsOne group of 25 patients underwent unrestricted KA TKA with manual instruments. Another group of 25 patients had native knees. Single‐plane fluoroscopy imaged each knee while patients performed step‐up and chair rise activities. Following 3D model‐to‐2D image registration, anterior–posterior (A‐P) positions of the femoral condyles were determined. Changes in A‐P positions with flexion were used to determine tibial rotation.ResultsAt maximum flexion, mean tibial rotations of KA TKA knees were comparable to native knees (Step up: 12.3° ± 4.4° vs. 13.1° ± 12.0°, p = 0.783; Chair Rise: 12.7° ± 6.2° vs. 12.6° ± 9.5º, p = 0.941). However, paths of rotation differed in that screw home motion was less evident in KA TKA knees. At 8 months follow‐up, the median Forgotten Joint Score was 69 points (range 65 to 85), the median Oxford Knee Score was 43 points (range 40 to 46), and mean knee flexion was 127º ± 8°.ConclusionsThe ball‐in‐socket medial, flat lateral insert and PCL retention implanted with unrestricted KA TKA restored in vivo native knee tibial rotation at maximum flexion for each activity and high function without stiffness. Providing high A‐P stability, this implant design might benefit patients desiring to return to demanding work and recreational activities.Level of evidenceTherapeutic – Level II.
Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest
Authors: Hua Tianfeng , Chu Yuqian , Wang Minjie , Zhang Yijun , Shi Wei , Huang Qihui , Zhang Liangliang , Yang Min 
Published: November 2023

Abstract
Background
Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some patients may eventually progress to multiple organ failure. There is evidence that heart failure is the terminal stage in the development of various cardiovascular diseases. Although the cardio-protective effect of canagliflozin (CANA) has been confirmed in large clinical studies and recommended in domestic and international heart failure-related guidelines, the effectiveness of CANA after resuscitation remains unclear. In this study, we constructed a modified CA/CPR rat model to investigate whether CANA administered on post-resuscitation improves myocardial function.

Methods
Twenty-fourth healthy male Sprague–Dawley rats were randomized into four groups: (1) Sham + placebo group, (2) Sham + CANA group, (3) CPR + placebo group, and (4) CPR + CANA group. Ventricular fibrillation was induced by transcutaneous electrical stimulation on epicardium. After 6 min untreated ventricular fibrillation, chest compressions was initiated. The rats were received an injection of placebo or canagliflozin (3 ug/kg) randomly 15 min after restore of spontaneous circulation (ROSC). Electrocardiogram (ECG) and blood pressure were continuously detected in each group throughout the experiment. The rats were killed 6 h after ROSC to collected the arterial serum and myocardial tissue. Myocardial injury was estimated with concentrations of inflammatory factors, oxidative stress indexes and, apoptosis index, myocardial injury markers, echocardiography and myocardial pathological slices.

Results
After resuscitation, mean arterial pressure (MAP) were significantly increased after cardiopulmonary resuscitation in CANA group rats when compared with placebo group. Heart rate, body lactate returned and left ventricular ejection fraction (LVEF) to normal levels in a shorter time and the myocardial injury was obviously attenuated in CPR + CANA group. Inflammatory factors (IL-6, TNF-α) and oxidative stress indexes (MAD, SOD, CAT) were dramatically decreased with the administration of CANA. The expression of apoptosis index (BAX, caspase-3) were higher in CPR + placebo group and the expression of anti-apoptosis index (Bcl-2) was lower (P < 0.05).

Conclusions
The administration of CANA effectively reduces myocardial ischaemia/reperfusion (I/R) injury after cardiac arrest and cardiopulmonary resuscitation (CPR), and the underlying mechanism may be related to anti-inflammation, oxidative stress and apoptosis.
Microalgae and co-culture for polishing pollutants of anaerobically treated agro-processing industry wastewater: the case of slaughterhouse
Authors: Bedane Dejene Tsegaye , Asfaw Seyoum Leta 
Published: November 2023

AbstractAnaerobically treated slaughterhouse effluent is rich in nutrients, organic matter, and cause eutrophication if discharged to the environment without proper further treatment. Moreover, phosphorus and nitrogen in agro-processing industry wastewaters are mainly removed in the tertiary treatment phase. The objective of this study is to evaluate the pollutant removal efficiency of Chlorella and Scenedesmus species as well as their co-culture treating two-phase anaerobic digester effluent through microalgae biomass production. The dimensions of the rectangular photobioreactor used to conduct the experiment are 15 cm in height, 20 cm in width, and 30 cm in length. Removal efficiencies between 86.74–93.11%, 96.74–97.47%, 91.49–92.91%, 97.94–99.46%, 89.22–94.28%, and 91.08–95.31% were attained for chemical oxygen demand, total nitrogen, nitrate, ammonium, total phosphorous, and orthophosphate by Chlorella species, Scenedesmus species, and their co-culture, respectively. The average biomass productivity and biomass yield of Chlorella species, Scenedesmus species, and their co-culture were 1.4 ± 0.1, 1.17 ± 0.12, 1.5 ± 0.13 g/L, and 0.18, 0.21, and 0.23 g/L*day, respectively. The final effluent quality in terms of chemical oxygen demand, total nitrogen, and total phosphorous attained by Chlorella species and the co-culture were below the permissible discharge limit for slaughterhouse effluent standards in the country (Ethiopia). The results of the study showed that the use of microalgae as well as their co-culture for polishing the nutrients and residual organic matter in the anaerobically treated agro-processing industry effluent offers a promising result for wastewater remediation and biomass production. In general, Chlorella and Scenedesmus species microalgae and their co-culture can be applied as an alternative for nutrient removal from anaerobically treated slaughterhouse wastewater as well as biomass production that can be used for bioenergy.
Graphical Abstract
Unraveling the mysteries of macular telangiectasia 2: the intersection of philanthropy, multimodal imaging and molecular genetics. The 2022 founders lecture of the pan American vitreoretinal society
Authors: Wu Lihteh 
Published: November 2023

Abstract
Purpose
Offer a personal perspective on the scientific advances on macular telangiectasia type 2 (MacTel2) since the launch of the MacTel Project in 2005.

Design
Literature review and personal perspective.

Methods
Critical review of the peer-reviewed literature and personal perspective.

Results
Generous financial support from the Lowy Medical Research Institute laid the foundations of the MacTel Project. MacTel Project investigators used state of the art multimodal retinal imaging and advanced modern biological methods to unravel many of the mysteries surrounding MacTel2. Major accomplishments includes elucidation of the pathogenic role that low serine levels, elevated 1-deoxysphingolipids and other mechanisms induce mitochondrial dysfunction which lead to Müller cell and photoreceptor degeneration; the use of objective measures of retinal structures such as the area of ellipsoid zone disruption as an outcome measure in clinical trials; the demonstration that the ciliary neurotrophic factor slows down retinal degeneration and the development of a new severity scale classification based on multimodal imaging findings.

Conclusions
MacTel2 is a predominantly metabolic disease characterized by defects in energy metabolism. Despite relatively good visual acuities, MacTel2 patients experience significant visual disability. The Mac Tel Project has been instrumental in advancing MacTel2 knowledge in the past two decades.
Biomolecular mechanisms of epileptic seizures and epilepsy: a review
Authors: Sumadewi Komang Trisna , Harkitasari Saktivi , Tjandra David Christopher 
Published: November 2023

AbstractEpilepsy is a recurring neurological disease caused by the abnormal electrical activity in the brain. This disease has caused about 50 new cases in 100,000 populations every year with the clinical manifestations of awareness loss, bruising, and mobility abnormalities. Due to the lack understanding of the pathophysiology behind the illness, a wide variety of medications are available to treat epilepsy. Epileptogenesis is the process by which a normally functioning brain undergoes alterations leading to the development of epilepsy, involving various factors. This is related to the inflammation which is driven by cytokines like IL-1 and tumor necrosis factor-α (TNF-α) leads to neuronal hyperexcitability. Pro-inflammatory cytokines from activated microglia and astrocytes in epileptic tissue initiate an inflammatory cascade, heightening neuronal excitability and triggering epileptiform activity. The blood-brain barrier (BBB) maintains central nervous system integrity through its tight endothelial connections, but inflammation impact BBB structure and function which leads to immune cell infiltration. The mammalian target of rapamycin (mTOR) pathway’s excessive activation influences epileptogenesis, impacting neuronal excitability, and synapse formation, with genetic mutations contributing to epilepsy syndromes and the modulation of autophagy playing a role in seizure onset. The apoptotic pathway contribute to cell death through glutamate receptor-mediated excitotoxicity, involving pro-apoptotic proteins like p53 and mitochondrial dysfunction, leading to the activation of caspases and the disruption of calcium homeostasis. Ionic imbalances within neural networks contribute to the complexity of epileptic seizures, involving alterations in voltage-gated sodium and potassium channels, and the formation of diverse ion channel subtypes. Epileptogenesis triggers molecular changes in hippocampus, including altered neurogenesis and enhanced expression of neurotrophic factors and proteins. Oxidative stress leads to cellular damage, disrupted antioxidant systems, and mitochondrial dysfunction, making it a key player in epileptogenesis and potential neuroprotective interventions. Thalamocortical circuitry disruption is central to absence epilepsy, the normal circuit becomes faulty and results in characteristic brain wave patterns.