bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measures of Ethics and Social Responsibility Among Undergraduate Engineering Students: Findings from a Longitudinal Study
Authors: Howland Shiloh James , Jesiek Brent K. , Claussen Stephanie , Zoltowski Carla B. 
Published: February 2024

AbstractPrior research on engineering students’ understandings of ethics and social responsibility has produced mixed and sometimes conflicting results. Seeking greater clarity in this area of investigation, we conducted an exploratory, longitudinal study at four universities in the United States to better understand how engineering undergraduate students perceive ethics and social responsibility and how those perceptions change over time. Undergraduate engineering students at four U.S. universities were surveyed three times: during their 1st (Fall 2015), 5th (Fall 2017), and 8th semesters (Spring 2019). The students who completed all three surveys (n = 226) comprise the sample that was analyzed in this paper for changes in their scores on five instruments: Fundamentals of Engineering/Situational Judgment, Moral Disengagement, ABET Engineering Work and Practice Considerations, Macroethics, and Political and Social Involvement Scale. We found that students modestly increased their knowledge of ethics and ability to apply that knowledge in situations calling for them to exercise judgment. In addition, they consistently indicated that health and safety considerations in engineering were of highest importance. They also showed steady levels of social consciousness over time, in contrast to other studies which detected a culture of increasing disengagement in engineering students throughout the four years of their undergraduate studies.
Impact of COVID-19 on testicular function: a systematic review and meta-analysis
Authors: Cannarella Rossella , Marino Marta , Crafa Andrea , Bagnara Vincenzo , La Vignera Sandro , Condorelli Rosita A. , Calogero Aldo E. 
Published: February 2024

Abstract
Introduction
Studies investigating the effects of SARS-CoV-2 on male reproductive function are few and heterogeneous, and results are often conflicting. This systematic review and meta-analysis was carried out on studies conducted in men with active or anamnestic SARS-CoV-2 infection to evaluate its consequences on the male sex hormone profile and semen parameters.

Materials and method
This meta-analysis follows the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocols. PubMed, Scopus, Cochrane, and Embase databases were searched to identify relevant studies. We originally selected 3553 articles. After the eligibility phase, 16 articles met our inclusion criteria encompassing 11 case-control studies and 5 cohort studies (2 prospective and 3 retrospective studies). We performed the quantitative analysis with Comprehensive Meta-Analysis Software. Cochran-Q and heterogeneity (I2) indexes were used to assess statistical heterogeneity. Sensitivity analysis and publication bias tests were also performed.

Results
Overall, 1250 patients with active or recent (up to 80 days before) COVID-19 infection and 1232 matched healthy controls were included. Sperm concentration, total sperm count, and total motility were significantly lower in patients compared with controls. Patients also showed lower levels of total testosterone and follicle-stimulating hormone, and higher levels of luteinizing hormone, 17β-estradiol, and prolactin compared with healthy controls. None of the included studies found the presence of SARS-CoV-2 mRNA in the semen of infected patients.

Conclusion
The present systematic review and meta-analysis suggests the presence of an association between SARS-CoV-2 infection and primary testicular damage manifested with a picture of altered steroidogenesis and worsening spermatogenesis. The absence of the virus in the seminal fluid indicates a low possibility of sexual transmission of the infection to partners and offspring. However, our findings mostly show short-term follow-up, while few studies have considered the long-term consequences of the viral infection, thus further studies are needed to evaluate the long-term consequences on male reproductive health.
Precise control of microfluidic flow conditions is critical for harnessing the in vitro transfection capability of pDNA-loaded lipid-Eudragit nanoparticles
Authors: Santhanes Diviya , Zhang Huiming , Wilkins Alex , Aitken Robert John , Gannon Anne-Louise , Liang Mingtao 
Published: February 2024

AbstractMicrofluidics is widely regarded as a leading technology for industrial-scale manufacture of multicomponent, gene-based nanomedicines in a reproducible manner. Yet, very few investigations detail the impact of flow conditions on the biological performance of the product, particularly biocompatibility and therapeutic efficiency. Herein, this study investigated the engineering of a novel lipid-Eudragit hybrid nanoparticle in a bifurcating microfluidics micromixer for plasmid DNA (pDNA) delivery. Nanoparticles of ~150 nm in size, with uniform polydispersity index (PDI = 0.2) and ξ-potential of 5–11 mV were formed across flow rate ratios (FRR, aqueous to organic phase) of 3:1 and 5:1, respectively. The hybrid nanoparticles maintained colloidal stability and structural integrity of loaded pDNA following recovery by ultracentrifugation. Importantly, in vitro testing in human embryonic kidney cell line (HEK293T) revealed significant differences in biocompatibility and transfection efficiency (TE). Lipid-Eudragit nanoparticles produced at FRR 3:1 displayed high cellular toxicity (0–30% viability), compared with nanoparticles prepared at FRR 5:1 (50–100% viability). Red fluorescent protein (RFP) expression was sustained for 24–72 h following exposure of cells to nanoparticles, indicating controlled release of pDNA and trafficking to the nucleus. Nanoparticles produced at FRR 5:1 resulted in markedly higher TE (12%) compared with those prepared at FRR 3:1 (2%). Notably, nanoparticles produced using the bench-scale nanoprecipitation method resulted in lower biocompatibility (30–90%) but higher RFP expression (25–38%). These findings emphasize the need for in-depth analysis of the effect of formulation and flow conditions on the physicochemical and biological performance of gene nanomedicines when transitioning from bench to clinic.
Graphical abstract
Transitioning lipid-Eudragit hybrid nanoparticles from bench-scale nanoprecipitation to industrial-scale microfluidics
Terahertz Time-Domain Spectroscopic (THz-TDS) Insights into Protein Deformation
Authors: Abouelsayed A. , El-Bahy Gamal S. , Abdelrazzak Abdelrazek B. 
Published: February 2024

AbstractIn this study, we utilized terahertz time-domain spectroscopy (THz-TDS) to study the radiation-induced protein deformation. The absorption coefficient spectra obtained from THz-TDS measurements in the frequency range (0.06–2 THz) was fitted using the Lorentzian model. The absorption coefficient fitting data was used to identify the α-helix and β-structure relative contributions in the protein secondary structure of the kidney tissue of rats irradiated with 10-cGy and 2-Gy X-ray separately or in combination. Our data show that 2-Gy X-irradiation leads to an increase in the β-structure contribution associated with a decrease in the α-helix contribution as indicated by the fitting parameters extracted from fitting the absorption coefficient α(ω) spectra with the Lorentzian function. The results point out that there is a strong correlation between the strength of the hydrogen bonds located between or inside the polypeptide chains of the extended β-sheet and α-helix, respectively, and the absolute value of the absorption coefficient α(ω), the refractive index, and the dielectric constant. The lowest refractive index and dielectric constant are recorded in the 2-Gy-irradiated group followed by the 10-cGy–2 Gy-irradiated group while the least effect was recorded in the 10-cGy-irradiated group. These data provide evidence of the adaptive effect of the 10-cGy X-irradiation delivered 24 h prior to the 2-Gy x-irradiation.
The prognostic value of two histopathologic classification models of ANCA-associated glomerulonephritis: a prospective study
Authors: Christodoulou Michalis , Moysidou Eleni , Lioulios Georgios , Stai Stamatia , Bandis Konstantinos , Flaris Nikolaos , Nikolaidou Christina , Fylaktou Asimina , Papagianni Aikaterini , Stangou Maria 
Published: February 2024

Abstract
Background
Berden Classification and anti-neutrophil cytoplasmic antibody (ANCA) Renal Risk Score are classification models for rating renal histology and predicting outcome in patients with ANCA-associated Vasculitis/Glomerulonephritis (AAV/GN). In the present study we compare their ability to predict renal function outcome in short- and long-term follow up.

Methods
Patients with an initial diagnosis of AAV/GN based on kidney biopsy were classified according to Berden and Renal Risk Score, started on the same treatment protocol, and were followed prospectively for up to 60 months. Renal function was recorded at 3mo(T3), 6mo(T6) and 60mo(T60), and results were compared to both classification systems.

Results
Ninety four AAV/GN patients, M/F = 36/58, age = 60.05 (18–82)yrs were included. Based on Berden classification, patients grouped as Focal (n = 24), Crescentic (n = 35), Mixed (n = 21) and Sclerotic (n = 14), had significant differences in estimated glomerular filtration rate (eGFR) only at T3, while the percentage of those requiring hemodialysis differed at T0, T3, T6 but not at T60. According to the Renal Risk Score, patients were classified as Low (n = 8), Medium (n = 47) and High (n = 39) risk, and showed significant differences in both eGFR levels, proportion of hemodialysis, at T0, T3, T6 and end-stage kidney disease (ESKD) at T60. Even patients classified as Mixed (Berden) and as Medium or High risk (Renal Risk Score) had significant improvement from T0 to T6. Relapse could not be predicted by either system.

Conclusion
Both methods were able to predict short-term renal function outcome and need for hemodialysis, but the Renal Risk Score showed significant superiority in predicting renal function outcome and ESKD after long-term follow up.

Graphical Abstract
Analyzing concentration in the Greek public procurement market: a network theory approach
Authors: Pliatsidis Andreas Christos 
Published: February 2024

AbstractThis study uses network theory to analyze the structure and concentration of the Greek public procurement market, focusing on the relationships between Contracting Authorities (CAs) and Economic Operators (EOs) within different Common Procurement Vocabulary (CPV) groups. By examining degree distribution curves and identifying dominant economic operators, we gain valuable insights into market dynamics and competition in Greece. The findings reveal the presence of market concentration, where a few EOs receive a disproportionate share of contracts within certain CPV groups which suggests potential market dominance and lack of competition. In contrast, some CPV groups demonstrate a more balanced distribution of contracts among EOs, suggesting a healthier competitive environment. The analysis of degree distributions between sub-networks based on CPV groups indicates variations in market structures between sectors. These differences highlight the heterogeneity in the Greek public procurement market, as well as the need for sector-specific policy interventions. Given that the concentration of contract awards raises competition, fairness and transparency concerns, the implications of the findings are important for policymakers, regulators and stakeholders involved in the Greek public procurement market. While this study provides valuable information, limitations including variations in data availability and potential inaccuracies in recorded information exist. Future research should address these limitations and explore the effects of market concentration on CPV codes in greater depth. This study contributes to the public procurement literature and serves as a basis for further research and policy making in the Greek procurement sector.
A SAMOAN Pedagogy of the Heart: ‘O auala a’oa’o e afua ma fa’atino mai le fatu
Authors: Taleni Leali’ie’e Tufulasifa’atafatafa , Surtees Nicola 
Published: February 2024

AbstractPasifika student engagement and achievement remain an ongoing concern in Aotearoa New Zealand with inequitable outcomes a reality. This article opens with a short story about Amosa, a Samoan student, to highlight some of the ways inequitable outcomes can become a reality in educational contexts where curriculum content is disconnected from culture. We offer our introductory conceptualisation of a pedagogy of the heart situated in the field of Pasifika educational outcomes, as a possible response to such disconnection. Conceptualised as the practice of teaching both from and with the heart, a pedagogy of the heart is a culturally-based pedagogy and can be understood as a form of tautua or service. Underpinned by tautua and other key Pasifika values such as alofa (love) and osiosiga (reciprocity), we argue a pedagogy of the heart has the potential to lift Pasifika student engagement and achievement through utilising these values as a catalyst for learning. After addressing the pedagogy’s significance and how it might be implemented, we conclude with some reflective questions designed to encourage thinking about the pedagogy in philosophy and practice, while maintaining its adoption will increase opportunities for Pasifika students and their teachers’ to thrive.
Inconsistent Atlantic Links to Precipitation Extremes over the Humid Tropics
Authors: Nnamchi Hyacinth C. , Diallo Ismaila 
Published: February 2024

AbstractThis study investigates extreme wet and dry conditions over the humid tropics and their connections to the variability of the tropical ocean basins using observations and a multi-model ensemble of 24 state-of-the-art coupled climate models, for the 1930–2014 period. The extreme wet (dry) conditions are consistently linked to Central Pacific La Niña (Eastern Pacific El Niño), the weakest being the Congo basin, and homogeneous patterns of sea surface temperature (SST) variability in the tropical Indian Ocean. The Atlantic exhibits markedly varying configurations of SST anomalies, including the Atlantic Niño and pan-Atlantic decadal oscillation, with non-symmetrical patterns between the wet and dry conditions. The oceanic influences are associated with anomalous convection and diabatic heating partly related to variations in the strength of the Walker Circulation. The observed connection between the Amazon basin, as well as the Maritime continent, and the Indo-Pacific variability are better simulated than that of the Congo basin. The observed signs of the Pacific and Indian SST anomalies are reversed for the modelled Congo basin extreme conditions which are, instead, tied to the Atlantic Niño/Niña variability. This Atlantic–Congo basin connection is related to a too southerly location of the simulated inter-tropical convergence zone that is associated with warm SST biases over the Atlantic cold tongue. This study highlights important teleconnections and model improvements necessary for the skillful prediction of extreme precipitation over the humid tropics.
Estimation of the Relative Chlorophyll Content of Carya illinoensis Leaves Using Fractional Order Derivative of Leaf and Canopy Scale Hyperspectral Data
Authors: Xu Jiajia , Fu Genshen , Yan Lipeng , Yu Lei , Kuang Fan , Huang Qingfeng , Tang Xuehai 
Published: February 2024

AbstractChlorophyll is a crucial physiological and biochemical indicator that impacts plant photosynthesis, accumulation of photosynthetic products, and final yield. The measurement and analysis of chlorophyll content in plants can provide valuable insights into their nutritional status and overall health. The non-destructive and efficient estimation of relevant plant physiological and biochemical indicators using hyperspectral technology can provide a reliable method for collecting data on nutrient levels and health status during plant growth and development. Fifty-three Carya illinoensis plants of Jiande and Changlin series known for their exceptional qualities and significant economic benefits were used as the research object for collecting their leaf and canopy hyperspectral data. Firstly, fractional order derivative (FOD) was used for spectral preprocessing. Secondly, the spectral response relationship between spectrum and relative chlorophyll content (soil and plant analyzer development, SPAD) was explored by combining single-band and two-band spectral index (normalized difference spectral index, NDSI). The correlation coefficient of Pearson correlation analysis was used to estimate the linear correlation between variables. Finally, the correlation between the spectral feature variables and SPAD was analyzed and calculated. Top 10 absolute values of the correlation coefficients were screened out as modeling variables. eXtreme gradient boosting (XGBoost) machine learning algorithm was used to construct the optimal estimation model of SPAD of Carya illinoensis leaves. Results showed that the correlation between leaf and canopy spectrum after FOD pretreatment and SPAD was substantially improved, compared with raw spectrum. FOD combined with leaf and canopy NDSI was more effective than single band in improving the correlation between spectral characteristics and target components, which was increased by 0.166 and 0.338, respectively. The leaf spectrum could estimate SPAD more accurately than that of canopy spectrum. The optimal SPAD model was the 0.5th-order derivative transformation combined with two-band leaf spectral index (NDSI) model. The R2 P was 0.788, and the RMSEP was 0.842 in prediction set. On one hand, this study confirms the feasibility of rapid and non-destructive estimation of SPAD of Carya illinoensis leaves using hyperspectral technology. On the other hand, FOD combined with two-band spectral indices can significantly improve the response relationship between spectral characteristics and target variables, enrich hyperspectral data processing methods, and propose a novel approach for the detection of plant nutrient level and health.
An Assessment on the Carbon Footprint of a Football Club—an Action Research from Theory to Practice
Authors: Khanna Manav , Daddi Tiberio , Merlo Federico , Iraldo Fabio 
Published: February 2024

AbstractThere is a lack of academic literature that explores the evaluation of football club’s carbon footprints. To the best of the author’s knowledge, this study is the first study where the football’s club’s overall carbon footprints were assessed. This study’s main objectives were to measure the football club environmental impact and promote the reduction of greenhouse gases (GHGs) emissions for famous significant sports events such as the Federation Internationale de Football Association (FIFA) and The Union of European Football Associations (UEFA) matches. The football club is a part of one of the biggest football clubs in Europe, which operates, manages, and maintains various facilities by assisting the football club in decision-making processes to identify the most relevant business engagement areas. The following research questions were considered: (a) What are the hotspots and the most significant contributors to GHG emissions of a football club? (b) How to improve emissions management within the stadium organization? (c) How to establish a carbon reduction and management plan? The researchers visited this stadium to collect data and interview managers of the football club. The GHG assessment results provide some relevant confirmation of the guidelines that emerged during the onsite visit. This study found that indirect emissions produced by a supporter’s transportation mode are equivalent to 38%, followed by energy consumption, accounting for 25% of the total GHG emissions. Specific future recommendations for sports organizations, such as (i) intermediate goal is to cut GHG emissions by at least 50% by 2030 and (ii) model scope 3 emissions and set scope 3 targets if scope 3 emissions account for 40% or more of their overall emissions, have emerged after this study.
Hegel, Beall, and the logic of Vereinigung
Authors: Ficara Elena 
Published: February 2024

AbstractIn 2023, Beall and Ficara present what they call Hegelian conjunctions. A Hegelian conjunction is a true conjunction of contradictory opposites in which the conjuncts, separately taken, are untrue and for which simplification fails. The analysis in Beall & Ficara History and Philosophy of Logic 44 (2) 119-131, 2023 is important for various reasons. First, for overcoming the deleterious state of estrangement between two ways of conceiving and practicing logic, the “dialectical” or “continental” and the “analytical” one. Second, for strengthening a new, promising way of conceiving conjunction in paraconsistency (d’Agostini Synthese 199, 6845 6874, 2021). Yet it needs an enlargement, mainly in two dimensions, a hermeneutical and a logical one. The former concerns the textual basis used by Beall and Ficara for motivating their account (the focus of their analysis is a small part of the early Hegelian fragment on Vereinigung – unification/conjunction). The latter is the semantics proposed by Beall and Ficara. In this paper, I focus on the first dimension, in the conviction that the condition for making the chief formal characteristics of dialectics (the logical dimension) clearer is a grasp of the Hegelian fragment in its entirety and complexity. The fragment is crucial for thinking about the logic, metaphysics and epistemology of true contradictions. Yet it counts as obscure. My aim is to make its content more accessible, and to present its relevance for conjunctive paraconsistency.
Assessment, credential, or both? Higher education faculty’s design principles for micro-credentials
Authors: Reed Anne , Kong Yiren , Abramovich Samuel 
Published: February 2024

AbstractThe rise of small, skills-focused credentials, also known as micro-credentials, has garnered considerable attention in recent years. By offering micro-credentials, institutions of higher education can provide additional credential options, thereby attracting more diverse audiences beyond degree-seekers. However, amidst their growth, fundamental questions surrounding their effective design and pedagogical implementation remain. This lack of clarity may inadvertently hinder their effectiveness. To address this gap, there is a need for studies that examine the perspectives and practices of faculty involved in micro-credential development and delivery. This study employed a single-embedded case design to investigate the perceptions and practices of faculty members who implemented micro-credentials for a pilot program at a large public research university. Specifically, this study aimed to identify faculty perceptions of the assessment and credentialing affordances of micro-credentials, and strategies employed to integrate these affordances into the design of micro-credentials. In-depth interviews were conducted with faculty members representing a diverse array of academic disciplines. Findings revealed that faculty need support in recognizing and integrating certain characteristics of quality assessments when designing micro-credentials, including aligning of assessments with a micro-credential’s delivery method, and integrating equity-oriented assessments into the design. These findings underscore the necessity for interventions and training programs aimed at integrating quality assessment practices into micro-credential design.