bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olfactory associative learning in the Australian stingless bee Tetragonula carbonaria
Authors: Ludowici M. , Beekman M. , Gloag R. 
Published: November 2023

AbstractFlower-visiting social insects use a variety of cues to help them learn and recall which flowers are high-quality resources, including the flower odour. In addition, some species may learn to respond to the odours left at flowers by other insects, either to avoid flowers that have likely been depleted by recent visitors, or to identify profitable floral patches being used by competitors. For example, Australian stingless bees were observed to be more attracted to food sources recently visited, and thus odour-marked, by other stingless bees or honey bees than food sources with no prior visits. Here, we use a proboscis extension response (PER) protocol to investigate the capacity for olfactory associative learning in the Australian stingless bee, Tetragonula carbonaria. We test the ability of T. carbonaria to learn to associate a food reward with each odour in two paired sets of odours: (1) vanilla vs. lavender, and (2) linalool vs. a synthetic version of the honey bee pheromone Nasonov. After conditioning, T. carbonaria foragers demonstrated successful discrimination between the two different odours in a set, learnt to associate all four test odours with a food reward, and maintained this association for 15 min after training. In all, our results, therefore, show that PER can be used to investigate associative learning in T. carbonaria and support olfactory associative learning as a mechanism by which the odours of both flowers and other bees affect foraging decisions in this species.
Models to estimate genetic gain of soybean seed yield from annual multi-environment field trials
Authors: Krause Matheus D. , Piepho Hans-Peter , Dias Kaio O. G. , Singh Asheesh K. , Beavis William D. 
Published: November 2023

AbstractKey messageSimulations demonstrated that estimates of realized genetic gain from linear mixed models using regional trials are biased to some degree. Thus, we recommend multiple selected models to obtain a range of reasonable estimates.AbstractGenetic improvements of discrete characteristics are obvious and easy to demonstrate, while quantitative traits require reliable and accurate methods to disentangle the confounding genetic and non-genetic components. Stochastic simulations of soybean [Glycine max(L.) Merr.] breeding programs were performed to evaluate linear mixed models to estimate the realized genetic gain (RGG) from annual multi-environment trials (MET). True breeding values were simulated under an infinitesimal model to represent the genetic contributions to soybean seed yield under various MET conditions. Estimators were evaluated using objective criteria of bias and linearity. Covariance modeling and direct versus indirect estimation-based models resulted in a substantial range of estimated values, all of which were biased to some degree. Although no models produced unbiased estimates, the three best-performing models resulted in an average bias of$$\pm\, 7.41$$±7.41 kg/ha$$^{-1}$$-1/yr$$^{-1}$$-1($$\pm\, 0.11$$±0.11 bu/ac$$^{-1}$$-1/yr$$^{-1}$$-1). Rather than relying on a single model to estimate RGG, we recommend the application of several models with minimal and directional bias. Further, based on the parameters used in the simulations, we do not think it is appropriate to use any single model to compare breeding programs or quantify the efficiency of proposed new breeding strategies. Lastly, for public soybean programs breeding for maturity groups II and III in North America, the estimated RGG values ranged from 18.16 to 39.68 kg/ha$$^{-1}$$-1/yr$$^{-1}$$-1(0.27–0.59 bu/ac$$^{-1}$$-1/yr$$^{-1}$$-1) from 1989 to 2019. These results provide strong evidence that public breeders have significantly improved soybean germplasm for seed yield in the primary production areas of North America.
Angiography-based coronary microvascular assessment with and without intracoronary pressure measurements: a systematic review
Authors: Kest Michael , Ágoston András , Szabó Gábor Tamás , Kiss Attila , Üveges Áron , Czuriga Dániel , Komócsi András , Hizoh István , Kőszegi Zsolt 
Published: November 2023

Abstract
Background
In recent years, several indices have been proposed for quantifying coronary microvascular resistance. We intended to conduct a comprehensive review that systematically evaluates indices of microvascular resistance derived from angiography.

Objective
The objective of this study was to identify and analyze angiography-derived indices of microvascular resistance that have been validated against an invasive reference method. We aimed to compare their limits of agreement with their reference methods and explore their advantages and inherent limitations.

Methods and results
We searched PubMed from inception until 2022 for studies on different techniques for quantifying microvascular resistance. Seven studies met the inclusion criteria. Five studies included techniques that applied calculations based solely on invasive angiography, and were validated against invasively measured thermodilution-derived index of microvascular resistance. The remaining two studies combined angiography with invasively measured intracoronary pressure data, and were validated against invasive Doppler measurements. We converted the ± 1.96 standard deviation limits of agreement with the reference method from the seven studies into percentages relative to the cut-off value of the reference method. The lower limits of agreement for angiography-based methods ranged from − 122 to − 60%, while the upper limits ranged from 74 to 135%. The range of the limits of agreement was considerably lower for the two combined angiography- and pressure-based methods, standing at − 52 to 60% and − 25 to 27%.

Conclusion
Our findings suggest that combined angiography- and pressure-based methods provide a more reliable assessment of microvascular resistance compared to methods relying solely on angiography.

Graphical Abstract

Central illustration. Comparative assessment of image-based methods quantifying microvascular resistance with and without intracoronary pressure measurements. Angiography-based methods rely on angiography alone to calculate the microvascular resistance by utilizing angiographic frame counting to extrapolate coronary flow (Q) and subsequently deriving distal coronary pressure using fluid dynamic equations. Combined angiography- and pressure-based methods utilize invasive intracoronary pressure gradients measured during rest and maximal vasodilation to determine coronary flow in their calculation of microvascular resistance. The combined methods showed more acceptable levels of agreement with their reference methods compared to angiography-based methods alone.
Illuminating Airway Nerve Structure and Function in Chronic Cough
Authors: Kornfield James , De La Torre Ubaldo , Mize Emily , Drake Matthew G. 
Published: November 2023

AbstractAirway nerves regulate vital airway functions including bronchoconstriction, cough, and control of respiration. Dysregulation of airway nerves underlies the development and manifestations of airway diseases such as chronic cough, where sensitization of neural pathways leads to excessive cough triggering. Nerves are heterogeneous in both expression and function. Recent advances in confocal imaging and in targeted genetic manipulation of airway nerves have expanded our ability to visualize neural organization, study neuro-immune interactions, and selectively modulate nerve activation. As a result, we have an unprecedented ability to quantitatively assess neural remodeling and its role in the development of airway disease. This review highlights our existing understanding of neural heterogeneity and how advances in methodology have illuminated airway nerve morphology and function in health and disease.
What determines complications and prognosis among patients subject to multivisceral resections for locally advanced gastric cancer?
Authors: Bobrzyński Łukasz , Pach Radosław , Szczepanik Antoni , Kołodziejczyk Piotr , Richter Piotr , Sierzega Marek 
Published: November 2023

Abstract
Background
Locally advanced gastric cancer (GC) extending to the surrounding tissues may require a multivisceral resection (MVR) to provide the best chance of cure. However, little is known about how the extent of organ resection affects the risks and benefits of surgery.

Methods
An electronic database of patients treated between 1996 and 2020 in an academic surgical centre was reviewed. MVRs were defined as partial or total gastrectomy combined with splenectomy, distal pancreatectomy, or partial colectomy.

Results
Suspected intraoperative tumour invasion of perigastric organs (cT4b) was found in 298 of 1476 patients with non-metastatic GC, and 218 were subject to MVRs, including the spleen (n = 126), pancreas (n = 51), and colon (n = 41). MVRs were associated with higher proportions of surgical and general complications, but not mortality. A nomogram was developed to predict the risk of major postoperative morbidity (Clavien–Dindo’s grade ≥ 3a), and the highest odds ratio for major morbidity identified by logistic regression modelling was found for distal pancreatectomy (2.53, 95% CI 1.23–5.19, P = 0.012) and colectomy (2.29, 95% CI 1.04–5.09, P = 0.035). Margin-positive resections were identified by the Cox proportional hazards model as the most important risk factor for patients’ survival (hazard ratio 1.47, 95% CI 1.10–1.97). The extent of organ resection did not affect prognosis, but a MVR was the only factor reducing the risk of margin positivity (OR 0.44, 95% CI 0.21–0.87).

Conclusions
The risk of multivisceral resections is associated with the organ being removed, but only MVRs increase the odds of complete tumour clearance for locally advanced gastric cancer.
Psychotherapies in opioid use disorder: toward a step-care model
Authors: Durpoix Amaury , Rolling Julie , Coutelle Romain , Lalanne Laurence 
Published: November 2023

AbstractOpioid use disorder (OUD) is characterized by a lack of control in opioid use, resulting in psychological distress and deficits in interpersonal and social functioning. OUD is often associated with psychiatric comorbidities that increase the severity of the disorder. The consequences of OUD are dramatic in terms of increased morbi-mortality. Specific medications and psychotherapies are essential tools not only in the treatment of OUD but also in the prevention of suicide and overdoses. In our review, we assess the different types of psychotherapies (counseling, motivational interviewing, contingency management, cognitive-behavioral therapy, and dialectical-behavior therapy) that are delivered to opioid users, either associated or un-associated with OUD medications and/or medications for psychiatric disabilities. We describe the application of these therapies first to adult opioid users and then to adolescents. This work led us to propose a stepped-care model of psychotherapies for OUD which provided information to assist clinicians in decision-making regarding the selection of psychotherapeutic strategies according to patients’ OUD severity.
Mediennutzung Heranwachsender: Eine Herausforderung in Public Health-Dimension … in all seiner diagnostischen Tragweite
Authors: Cassens Manfred , Zeller Carolin 
Published: November 2023

ZusammenfassungDer Beitrag fokussiert das seit den 2000ern gestiegene pathogene Mediennutzungsverhalten von Heranwachsenden im Alter von 6 bis 18 Jahren. Auf Deutschland bezogen betrifft dies auf der empirischen Basis freiwilliger Selbstauskünfte (2023) 4,3 von ca. 11 Mio. Heranwachsenden. Auffällig ist, dass sowohl stationäre als auch ambulante sekundär- und tertiärpräventive Versorgungen dieser Gruppe in vielen bis sehr vielen Fällen sog. F‑Diagnosen eine mediennutzende Komorbidität aufweisen. Diese ist jedoch sowohl nach ICD 10 als auch nach ICD 11 nur schwerlich klassifizierbar. Hinzu kommt, dass Stand 2023 im Rahmen der ärztlichen Diagnostik adäquate Tools zur eindeutigen Befundung fehlen. Evidenzbasis ist eine auf einer Literaturrecherche basierende Sekundärdatenanalyse (gem. AGENS-Standard), eingegrenzt auf deutsche und englische Sprache und ein Zeitfenster von 2016 bis 2023, zudem vier themenzentrierte Leitfadeninterviews mit international expertierten Personen. Die Daten wurden einer qualitativen Inhaltsanalyse unterzogen. Die Ergebnisse beider Datenquellen wurden trianguliert und abschließend einer qualitativen Induktion zugeführt. Die Forschungsarbeit verfolgte die Ziele, einerseits themenrelevante potenzielle Lücken in der ICD-11 zu identifizieren und andererseits Lösungsmöglichkeiten für diagnostische Tools vorzuschlagen. Im Sinne einer psychotherapeutischen Präventionsarbeit kommt der Beitrag zum einen zum Ergebnis, dass auch die in der ICD 11 erweiterten diagnostischen Kategorien die Abhängigkeitsphänomene neuer Medien nicht hinreichend erfassen. Zum anderen wird im Ergebnis mit dem Ambulanten Assessment eine Vorgehensweise beschrieben, deren Einsatz im Forschungskontext einen wesentlichen Beitrag zur Lösung bestehender Probleme leisten kann.
Evaluation of the probable synergistic toxicity of selected potentiated antiretroviral and antibiotics on some aquatic biomarker organisms
Authors: Omotola Elizabeth Oyinkansola , Genthe Bettina , Ndlela Luyanda , Olatunji Olatunde Stephen 
Published: November 2023

AbstractEnvironmental effects of active pharmaceutical compounds (APCs) in the environment are not well characterized, hence the need for comprehensive evaluation. This study employed three bioassays using three organisms, namely,Allium cepa,Daphnia magna, andSalmonella typhimurium, in the ecotoxicity study of lone and a mixture of selected APCs, namely, lamivudine (L), an antiretroviral, and ciprofloxacin (C) and sulfamethoxazole (S), antibiotics, at a concentration range between 10 and 100 ppb, in order to evaluate the potential of the lone and ternary mixture to exert synergistic toxicity. Study results from exposure to lone APCs showed that the L, C, and S trio individually had fatal impacts on daphnids, with mortality rates of 100, 75, and 95%, respectively, after 48 h. Sulfamethoxazole showed a mutagenic tendency, with a mutation ratio (background/sample ratio) of 2.0. Lamivudine showed a lethal impact on the root length ofA. cepa(p > 0.05,p = 3.60E–3). Further microscopic examination of theA. ceparoot tip revealed chromosomal aberrations on exposure to each compound. The LCS-mix ecotoxicology bioassays indicated a synergistic effect on the daphnids, probably due to potentiation. Although the LCS mix had a cytotoxic effect (evidenced by the absence of bacteria colonies) on exposed TA 98 P450Salmonella typhimuriumstrain, this effect was not observed in other bacterial strains. Microscopic examination ofA. cepaexposed to the LCS-mix revealed an aberration in the mitotic stage of the cell. The impact of combination of the pharmaceuticals in aqueous ecosystems was greater than when exposed to the tested individual pharmaceutical compounds. Study result showed that these compounds have tendencies to pose a higher risk to exposed living entities when in combined/potentiated forms, and this could lead to distortion of the regular functioning of the ecosystem, particularly bacterial and other microbial populations that are listed among primary producers of the aquatic food web.
Pathways of hydrogen atom diffusion at fcc Cu: Σ9 and Σ5 grain boundaries vs single crystal
Authors: Lousada Cláudio M. , Korzhavyi Pavel A. 
Published: November 2023

AbstractThe diffusion of H-atoms is relevant for innumerous physical–chemical processes in metals. A detailed understanding of diffusion in a polycrystalline material requires the knowledge of the activation energies (ΔEa’s) for diffusion at different defects. Here, we report a study of the diffusion of H-atoms at the Σ9 and Σ5 grain boundaries (GBs) of fcc Cu that are relevant for practical applications of the material. The complete set of possible diffusion pathways was determined for each GB and we compared the ΔEa at bulk fcc Cu with the landscape of ΔEa’s at these defects. We found that while a number of diffusion pathways at the GBs have high tortuosity, there are also many paths with very low tortuosity because of specific structural features of the interstitial GB sites. These data show that the diffusion of H-atoms at these GBs is highly directional but can be fast because at certain paths the ΔEa can be as low as 0.05 eV. The lowest energy paths for diffusion of H-atoms through the whole GB models are ΔEa = 0.05 eV for the Σ9 and ΔEa = 0.20 eV at Σ5 which compare with ΔEa = 0.42 eV for the bulk fcc crystal. This shows that H-atoms will be able to diffuse very fast at these defects. With the Laguerre–Voronoi tessellation method, we studied how the local atomic structure of the interstitial sites of the GBs leads to different ΔEa’s for diffusion of H-atoms. We found that the volume expansions and the coordination numbers alone cannot account for the magnitude of the ΔEa’s. Hence, we developed a symmetry quantifying parameter that measures the deviation of symmetry of the GB sites from that of the bulk octahedral site and hence accounts for the distortion at the GB site. Only when this parameter is introduced together with the volume expansions and the coordination numbers, it is possible to correlate the local structure with the ΔEa’s and to obtain descriptors of diffusion. The complete set of data shows that the extrapolation of diffusion data for H-atoms between different types of GBs is non-trivial and should be done with care.
The COVID-19 Pandemic’s Impact on Health Service Utilization Among Pregnant Women in Three Nigerian States: A Mixed Methods Study
Authors: Orji Bright , Bryce Emily , Odio Bartholomew , Onuoha Herbert , Njoku Elizabeth , Anoke Charity , Ugwa Emmanuel , Enne Joseph , Oniyire Adetiloye , Ibrahim Idris , Otolorin Emmanuel , Afolabi Kayode , Ogbulafor Nnenna C. , Oliveras Elizabeth 
Published: November 2023

Abstract
Objective
COVID-19 disrupted health service delivery and weakened global and national health systems. The objective of this study was to describe the changes in health service utilization in three local government areas (LGAs) in Nigeria and examine factors involved.

Methods
A cross-sectional mixed-methods approach was used. A total of 315 pregnant women seen for antenatal care in 80 health facilities in three LGAs between October 1 and November 30, 2020, participated in exit interviews; 93 women participated in focus group discussions (FGDs). Descriptive analyses and a multivariable logistic analysis were conducted to examine associations between characteristics and decreased service utilization. Content analysis was used to identify the emerging themes related to health service utilization during the pandemic.

Results
One quarter of women reported that they reduced or ceased health service. The biggest reported changes were in immunization (47 to 30%, p < 0.001) and a small but statistically significant decline in antenatal care (98.7 to 93.8%, p < 0.001) was observed. Qualitative findings show that lockdowns, transportation issues, increased costs and fear of contracting COVID-19 or being labeled as COVID-positive were the most common reasons for not seeking care during this period of the pandemic.

Conclusions
The pandemic negatively impacted health service utilization amongst pregnant women in Nigeria. A better understanding of differences in state response could help inform future actions. The findings highlight the need for health systems to consider how to facilitate service utilization during a pandemic, such as providing safe transport or increasing outreach, and to minimize stigma for those seeking care.
What one is not: a new scale to measure Negative Party Identity in multiparty systems
Authors: Mayer Sabrina J , Russo Luana 
Published: November 2023

AbstractThe concept of negative partisanship has lately become a highly salient topic, yet its current measurements are far from optimal as they do not account for negative partisanship’s nature as a social identity, nor are they applicable to multiparty systems. In this paper, we validate the negative partisanship (NPS) scale. By relying on expert interviews, cognitive pre-tests and a large-N survey in two countries, Germany (N = 1,911) and Italy (N = 1,440), we provide a construct validation using a nomological network based on previous studies and social identity literature. Our results show the applicability of the new instrument, the full five-item version as well as shorter conceptualizations, for the measurement of negative partisanship in multiparty systems.
Teachers’ prosociality and well-being at work: The mediating role of teacher engagement in family–school partnerships
Authors: Yotyodying Sittipan , Dettmers Swantje , Jonkmann Kathrin 
Published: November 2023

AbstractPast research provided strong evidence that positive family–school partnerships were not only beneficial for students’ school success, but they also helped to promote parental involvement in schooling. However, relatively little is known about teachers’ reasons for becoming engaged in family–school partnerships and the benefits of their engagement. In fact, the role of teachers in family–school partnerships requires prosocial actions (e.g., helping, sharing, feeling empathy). As guided by self-determination theory, previous studies suggest that prosocial-oriented persons tend to take prosocial actions and these actions tend to promote a social connection, thereby promoting well-being. To the best of our knowledge, this assumption has not been applied to research on family–school partnerships yet. The aim of this study was to examine whether teachers’ prosociality would be associated with their well-being at work (i.e., job satisfaction, work-related self-esteem) and whether this connection would be mediated by teacher engagement in family–school partnerships. Using the framework of the Vodafone Foundation Germany, we focused on two important aspects of teacher engagement: effective communication and educational cooperation. A total of 190 teachers (72% females; mean age: 44.78 years) participated in an online-survey. In line with SDT, teachers’ prosociality was associated with greater well-being at work even after controlling for teachers’ background (age, gender, experience, school track). As expected, this connection was partially mediated by teacher engagement in family–school partnerships. The results and implications of the present study are discussed.
Graphene oxide quantum dots membrane: a hybrid filtration-advanced technology system to enhance process of wastewater reclamation
Authors: Tshangana Charmaine , Muleja Adolph 
Published: November 2023

AbstractThe inability of wastewater treatment plants to effectively remove emerging pollutants has necessitated the need to develop newer advanced technologies. An integrated approach of combining advanced oxidation processes (AOPs) and membrane technologies promises superior performances. In this study, graphene oxide quantum dots-based membranes (GQDs-Ms) were fabricated via the phase inversion method. The GQDs-Ms revealed high oxygen content and a negative surface charge. The incorporating graphene oxide quantum dots (GQDs) into the polymer matrix led to enhanced hydrophilicity, pore size, porosity, improved flux as well as superior inhibition of Escherichia coli cells. A multi-AOPs approach was used in this work, wherein AOPs were applied as both pre-treatment (using GQDs) and post-treatment (combining GQDs with peracetic acid) in the disinfection of wastewater. The evaluation of GQDs-Ms performance was carried out and compared with a commercial membrane (Film Tec™NF270). The obtained % removals with GQDs-Ms were 83.45%, 64.12%, 40.76% and 70.36% for turbidity, total dissolved solids, total organic carbon and electrical conductivity, respectively, which compared nearly with commercial membrane’s performance. Interestingly, the integrated hybrid system can further remove and inactivate microbes in wastewater. The developed hybrid filtration-advanced technology system can substantially improve conventional wastewater treatment plants for water reuse.