bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial protein synthesis quality control
Authors: Koludarova Lidiia , Battersby Brendan J 
Published: January 2024

Abstract
Human mitochondrial DNA is one of the most simplified cellular genomes and facilitates compartmentalized gene expression. Within the organelle, there is no physical barrier to separate transcription and translation, nor is there evidence that quality control surveillance pathways are active to prevent translation on faulty mRNA transcripts. Mitochondrial ribosomes synthesize 13 hydrophobic proteins that require co-translational insertion into the inner membrane of the organelle. To maintain the integrity of the inner membrane, which is essential for organelle function, requires responsive quality control mechanisms to recognize aberrations in protein synthesis. In this review, we explore how defects in mitochondrial protein synthesis can arise due to the culmination of inherent mistakes that occur throughout the steps of gene expression. In turn, we examine the stepwise series of quality control processes that are needed to eliminate any mistakes that would perturb organelle homeostasis. We aim to provide an integrated view on the quality control mechanisms of mitochondrial protein synthesis and to identify promising avenues for future research.
Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis
Authors: Ouahed Jodie D , Griffith Alexandra , Collen Lauren V , Snapper Scott B 
Published: January 2024

Abstract
Monogenic causes of inflammatory bowel diseases (IBD) are increasingly being discovered. To date, much attention has been placed in those resulting from inborn errors of immunity. Therapeutic efforts have been largely focused on offering personalized immune modulation or curative bone marrow transplant for patients with IBD and underlying immune disorders. To date, less emphasis has been placed on monogenic causes of IBD that pertain to impairment of the intestinal epithelial barrier. Here, we provide a comprehensive review of monogenic causes of IBD that result in impaired intestinal epithelial barrier that are categorized into 6 important functions: (1) epithelial cell organization, (2) epithelial cell intrinsic functions, (3) epithelial cell apoptosis and necroptosis, (4) complement activation, (5) epithelial cell signaling, and (6) control of RNA degradation products. We illustrate how impairment of any of these categories can result in IBD. This work reviews the current understanding of the genes involved in maintaining the intestinal barrier, the inheritance patterns that result in dysfunction, features of IBD resulting from these disorders, and pertinent translational work in this field.
Reconceptualizing Advocacy through the Women, Peace and Security Agenda: Embodiment, Relationality, and Power
Authors: Achilleos-Sarll Columba 
Published: January 2024

Abstract
This article critically examines the embodied and relational politics of networked advocacy in the case of the Women, Peace and Security (WPS) agenda in the United Kingdom. Moving beyond liberal framings that position WPS advocacy as an attempt to overcome gender exclusion from peace and security policymaking, this article is concerned instead with the gendered, racialized, and classed logics and hierarchies (re)produced through the practice of WPS advocacy. Toward this end, this article conceptualizes advocacy as an embodied, relational practice where WPS meanings are shaped, power is negotiated, and individuals are interpolated into subject positions. This conceptual claim is substantiated through an initial, exploratory analysis of interviews conducted with UK NGO professionals and government officials. Examining the figures of the “critical friends” and the “shouty NGOs,” I demonstrate how modes of advocating for WPS are ascribed and inscribed to certain bodies, which, in turn, reproduce power relations that affect the possibilities of the agenda. By reconceptualizing advocacy, the article contributes not only to WPS scholarship on civil society and advocacy but to wider debates within international political sociology around embodiment, relationality, and power. Additionally, it contributes empirically by highlighting how NGOs advocate for the WPS agenda.
Boundary Work, Overlapping Identities, and Liminality in Communities of Practice: Diplomacy within and beyond ASEAN
Authors: Glas Aarie , Martel Stéphanie 
Published: January 2024

Abstract
Communities of practice (CoPs) are important sites of social interaction and are of growing concern in international relations. Much attention has been devoted to examining the existence and effect of these communities, and the kinds of practices and identities they coalesce around. Relatively less attention has been afforded to the relations between a CoP and what lies outside of it. In this article we examine encounters at the boundaries of CoPs. Empirically, we examine the boundaries and interactions of a community of diplomatic practice in the context of the Association of Southeast Asian Nations (ASEAN) as regional officials engage with extra-regional diplomats and “dialogue partners” operating within and alongside the organization. We find that the “boundary work” of these interactions are important sites of social interaction that constitute communities in important ways and make possible meaningful changes in identity and behavior. More broadly, we show that ASEAN’s unique position as a hub of a multilateral architecture that extends to a wider state membership provides prime terrain to inquire about what happens in liminal spaces of encounter between social agents of varied communities. To advance our claims, we draw on sixty-one semi-structured interviews with regional and extra-regional officials in Jakarta and elsewhere in the region, alongside analysis of public statements from diplomatic practitioners.
An Emergent Community of Cyber Sovereignty: The Reproduction of Boundaries?
Authors: Qiao-Franco Guangyu 
Published: January 2024

Abstract
This research probes the boundary-work of Communities of Practice (CoP) by examining China’s active efforts in advancing a state-centric approach in managing cyberspace in the international arena. Boundaries separating the Global North and South are reproduced in the expansion of what I call the “community of cyber sovereignty.” This phenomenon points to the CoP literature’s omission of the proactive aspects of boundary-work undertaken by core members and its surrounding and confounding historical contexts. I argue that boundary reproduction arises from both deliberate and unreflective moves in cultivating CoP. First, emerging from reflexivity in interacting with the external environment, practitioners in CoPs that are vigorously contested will likely replicate historically successful boundary drawing to acquire or maintain credibility. Second, CoP members engage in the habitual selection of strategies, anchoring the community toward sustaining relationships with actors that its members traditionally associate with. These proactive boundary-work dynamics are enabled by inclusive and exclusive mechanisms such as “brokering” varied practices to include potential members and “gatekeeping” others. My analysis suggests that scholarship must attend to actors’ proactive efforts to establish communities preferentially as well as their linkages with prevailing social structures.
Total metagenomes outperform viromes in recovering viral diversity from sulfuric soils
Authors: Bi Li , He Ji-Zheng , Hu Hang-Wei 
Published: January 2024

Abstract
Recent metagenomic advancements have offered unprecedented insights into soil viral ecology. However, it remains a challenge to select the suitable metagenomic method for investigating soil viruses under different environmental conditions. Here, we assessed the performance of viral size-fraction metagenomes (viromes) and total metagenomes in capturing viral diversity from hypersulfidic soils with neutral pH and sulfuric soils with pH &lt;3.3. Viromes effectively enhanced the sequencing coverage of viral genomes in both soil types. Viomes of hypersulfidic soils outperformed total metagenomes by recovering a significantly higher number of viral operational taxonomic units (vOTUs). However, total metagenomes of sulfuric soils recovered ~4.5 times more vOTUs than viromes on average. Altogether, our findings suggest that the choice between viromes and total metagenomes for studying soil viruses should be carefully considered based on the specific environmental conditions.
Mammography Screening Should Begin at Age 40 Years
Authors: Hendrick R Edward , Monticciolo Debra L 
Published: January 2024

Abstract
The 2023 U.S. Preventive Services Task Force draft recommendation statement on screening for breast cancer recommends lowering the starting age for biennial screening with mammography to age 40 years from 50 years, the age of screening initiation that the Task Force had previously recommended since 2009. A recent Perspective article in the New England Journal of Medicine by Woloshin et al contends that this change will provide no additional benefit and is unjustified. This article reviews the main ideas presented by Woloshin et al and provides substantial evidence not considered by those authors in support of screening mammography in U.S. women starting at age 40 years.
Response rates for lumbar spine, total hip, and femoral neck bone mineral density in men treated with abaloparatide: results from the ATOM study
Authors: Dhaliwal Ruban , Kendler David , Saag Kenneth , Ing Steven W , Singer Andrea , Adler Robert A , Pearman Leny , Wang Yamei , Mitlak Bruce 
Published: January 2024

Abstract
Osteoporosis in men is an underappreciated public health issue, accounting for approximately 30% of the societal burden of osteoporosis. Although the prevalence of osteoporosis in men is lower, fracture-related morbidity and mortality rates exceed those of women. Abaloparatide is a synthetic, 34-amino acid peptide with homology to human parathyroid hormone-related protein (PTHrP), which favors bone formation by selective activation of PTH receptor type 1. In the Abaloparatide for the Treatment of Men With Osteoporosis (ATOM; NCT03512262) trial, 228 men with primary or hypogonadism-associated osteoporosis were randomized to receive subcutaneous injections of abaloparatide 80 μg or placebo. Abaloparatide significantly improved LS, TH, and FN BMD when compared with placebo. In this prespecified analysis, the proportion of men with a percent change from baseline of &gt;0%, &gt;3%, and &gt; 6% in BMD at the LS, TH, and FN at 3, 6, and 12 mo and/or a shift in T-score category (based on LS and TH T-scores) at 12 mo was compared between the abaloparatide and placebo groups in ATOM. There were significantly more men with a BMD gain of &gt;3% at all 3 anatomical sites in the abaloparatide than placebo group at month 6 (18/122 [14.8%] vs 1/70 [1.4%], P = .002) and at month 12 (38/119 [31.9%] vs 1/66 [1.5%], P &lt; .0001). At month 3, more men treated with abaloparatide than placebo had a &gt; 3% BMD increase at the LS (82/134 [61.2%] vs 21/68 [30.9%], P &lt; .0001). A greater proportion of men treated with abaloparatide had an improvement in T-score category from osteoporosis to low BMD or normal when compared with placebo. In conclusion, use of abaloparatide compared with placebo for 12 mo resulted in significant and rapid improvements in BMD in men with osteoporosis from the ATOM study.
What Might Future Rights-Based Climate Litigation Look Like in Indonesia? A Preliminary Analysis
Authors: Cornelius Conrado M 
Published: January 2024

AbstractWhile there has been some climate litigations in Indonesia, a rights-based climate case has yet to emerge. On the other hand, several rights-based environmental cases have seen the light of day before the Indonesian courts, although with more failures than successes. This note explores the prospects and challenges for future rights-based climate litigation in Indonesia by reflecting on previous climate and rights-based environmental cases. At the same time, with reference to Urgenda, this note recognizes a growing global discourse on transnational climate litigation, unveiling the possibility of replicating successful climate litigation strategies from one jurisdiction to another. This note inquires into what potential plaintiffs can learn from Urgenda and previous Indonesian climate and rights-based environmental litigation to strategize future rights-based climate lawsuits before Indonesian courts.
Release the hens: a study on the complexities of guinea fowl as tick control
Authors: White Alexis L , Cumbie Alexandra , Brinkerhoff R Jory , Hynes Wayne L , Gaff Holly D 
Published: January 2024

Abstract
Established tick control strategies often involve methods that can be damaging to existing environmental conditions or natural host ecology. To find more environmentally friendly methods, biological controls, like predators of ticks, have been suggested. There are natural predators of ticks, but most are generalists and not expected to control tick populations. Helmeted guinea fowl (Numida meleagris (L.) (Galliformes: Numididae)) have been suggested to be biological controls of ticks, and therefore, tick-borne pathogens, but their potential role as hosts for ticks complicates the relationship. A study was conducted to assess whether guinea fowl reduces the abundance of lone star ticks, Amblyomma americanum (L.) (Acari: Ixodidae), or whether they are hosts of ticks. Using mark–recapture techniques, painted lone star ticks were placed into 3 different treatments: penned, excluded, and free range. The recapture rates of painted ticks were compared. There was a significant difference between excluded and free-range treatments, but not between excluded and penned or between free range and penned. To investigate the role of guinea fowl as hosts of ticks, coop floors were examined for engorged ticks. Engorged lone star nymphs that had fed on guinea fowl were found. Lastly, ticks collected were tested to identify the potential reduction in risk of tick-borne pathogens. This study found no evidence that guinea fowl are an effective biological control of lone star ticks or tick-borne pathogens, but they are hosts of lone star nymphs. Future studies are needed to assess the complex ecology of a biological control of ticks that is also a host.
Efficacy of Palivizumab Immunoprophylaxis for Reducing Severe RSV Outcomes in Children with Immunodeficiencies: A Systematic Review
Authors: Reicherz Frederic , Abu-Raya Bahaa , Akinseye Omolabake , Rassekh Shahrad Rod , Wiens Matthew O , Lavoie Pascal M 
Published: January 2024

Abstract

Background
Palivizumab is recommended for prevention of severe respiratory syncytial virus (RSV) disease in immunocompromised children, despite a lack of strong supporting evidence. The recent approval of substitute RSV-neutralizing monoclonal antibodies against RSV, offers an opportunity to synthesize the most current evidence supporting the palivizumab standard of care.

Objective
To evaluate the efficacy of palivizumab in preventing acute respiratory tract infection- or RSV-related hospitalization, or mortality in immunocompromised children.

Methods
We searched Ovid MEDLINE and EMBASE for published clinical studies that investigated outcomes of palivizumab use in children. We included clinical trials, cohort studies, and case–control studies. The primary outcomes were RSV-related or respiratory viral infection-related hospitalizations, or RSV-related mortality. This systematic review was registered in PROSPERO (ID CRD42021248619) and is reported in accordance with the PRISMA guidelines.

Results
From the 1993 records, six studies were eligible and included, for a total of 625 immunocompromised children with an heterogeneous composition of primary and acquired immunodeficiencies enrolled from palivizumab programs. There were no intervention studies. None of the studies included a control group. RSV hospitalizations were infrequent (0%–3.1% of children). Most children included received palivizumab, although one study (n = 56) did not specify how many received palivizumab. RSV mortality was neither observed, in three studies, nor reported, in three other studies.

Conclusions
The evidence supporting the use of palivizumab for prevention of severe RSV disease in immunocompromised children remains extremely limited and appears insufficient to justify prioritizing this intervention as the current standard of care over alternative interventions.
Treatment Patterns, Healthcare Resource Utilization, and Costs of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma in the US
Authors: Yang Xiaoqin , Zanardo Enrico , Lejeune Dominique , De Nigris Enrico , Sarpong Eric , Farooqui Mohammed , Laliberté François 
Published: January 2024

Abstract

Background
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia among US adults and has experienced a rapidly evolving treatment landscape; yet current data on treatment patterns in clinical practice and economic burden are limited. This study aimed to provide an up-to-date description of real-world characteristics, treatments, and costs of patients with CLL or small lymphocytic lymphoma (SLL).

Materials and Methods
Using retrospective data from the Optum Clinformatics DataMart database (January 2013 to December 2021), adults with diagnosis codes for CLL/SLL on two different dates were selected. An adapted algorithm identified lines of therapy (LOT). Treatment patterns were stratified by the index year pre- and post-2018. Healthcare resource utilization and costs were evaluated per patient-years.

Results
A total of 18 418 patients with CLL/SLL were identified, 5226 patients (28%) were treated with ≥1 LOT and 1728 (9%) with ≥2 LOT. Among patients diagnosed with CLL in 2014-2017 and ≥1 LOT (N = 2585), 42% used targeted therapy and 30% used chemoimmunotherapy in first line (1L). The corresponding proportions of patients diagnosed with CLL in 2018-2021 (N = 2641) were 54% and 16%, respectively. Total costs were numerically 3.5 times higher and 4.9 times higher compared with baseline costs among patients treated with 1L+ and 3L+, respectively.

Conclusion
This study documented the real-world change in CLL treatment landscape and the substantial economic burden of patients with CLL/SLL. Specifically, targeted therapies were increasingly used as 1L treatments and they were part of more than half of 1L regimens in recent years (2018-2021).
The Relationship Between Health-Related Quality of Life and Overall Survival in Patients With Advanced Renal Cell Carcinoma in CheckMate 214
Authors: Cella David , Choueiri Toni K , Hamilton Melissa , Blum Steven I , Ivanescu Cristina , Karu Karl , Ejzykowicz Flavia , Motzer Robert J 
Published: January 2024

Abstract

Background
In CheckMate 214 (median follow-up, 25.2 months), nivolumab plus ipilimumab yielded greater overall survival (OS) benefit than sunitinib in patients with intermediate-/poor-risk advanced renal cell carcinoma (aRCC). Health-related quality of life (HRQoL) assessed by the Functional Assessment of Cancer Therapy-Kidney Symptom Index-19 (FKSI-19) was also more favorable for the nivolumab plus ipilimumab group than the sunitinib group. We investigated whether HRQoL scores can predict OS of patients with 5 years follow-up in CheckMate 214.

Patients and Methods
CheckMate 214 was an open-label, phase III trial in previously untreated aRCC (N = 1096). Patients with intermediate-/poor-risk disease (International mRCC Database Consortium prognostic score ≥ 1; n = 847) were randomized to either nivolumab plus ipilimumab or sunitinib monotherapy. Pooled data for OS and FKSI-19 total and subscales (disease-related symptoms [DRS], DRS-physical [DRS-P], and function/well-being [FWB]) were analyzed. Relationships between HRQoL and OS were assessed using Cox proportional hazard models with baseline and longitudinal scores. Associations between HRQoL changes and OS were assessed by landmark analyses.

Results
Patients with higher FKSI-19 total and subscale scores at baseline had longer OS than patients with lower scores (HR ≤ 0.834; P &lt; .0001). Longitudinal models indicated stronger associations between HRQoL and OS (HR ≤ 0.69; P &lt; .001 for each). At 3 months after randomization, patients with stable/improved HRQoL versus baseline had longer median OS than patients with worsened/unobserved HRQoL versus baseline (55.9 and 26.0 months, respectively; HR = 0.56; 95% CI, 0.46-0.67; P &lt; .0001). Results at 6-, 9-, and 12-month landmarks were consistent with these findings.

Conclusion
In aRCC, patient-reported outcomes are important for HRQoL and prognostic evaluation.

Clinicaltrials.gov Identifier
NCT02231749; https://clinicaltrials.gov/ct2/show/NCT02231749.
Culture and Workplace Deviance
Authors: Raver Jana L. 
Published: January 2024

Abstract
Research and theory on culture and workplace deviance (including related constructs; e.g., bullying, aggression, counterproductive work behavior, harassment, incivility, abusive supervision) were rare until a decade ago, but this is now a flourishing area of scholarship. This chapter comprehensively reviews this body of research published since 2011. Key themes, findings, theoretical foundations, and methodologies are highlighted, along with the dilemmas and controversies surrounding the disparate treatment of workplace deviance in the literature. Key themes include evidence that several measures of workplace deviance are cross-culturally generalizable; increased methodological sophistication including tests of measurement equivalence and measuring theorized cultural mechanisms; and the emergence of larger multinational studies published by teams of global collaborators. Promising areas of inquiry for future research are also provided, grounded within theoretical principles that will advance scholarship. The chapter concludes with a synthesis of practical implications for organizational leaders and practitioners stemming from the current body of work.
Occupational Stress in the Global World
Authors: Spector Paul E. 
Published: January 2024

Abstract
The study of occupational stress had its beginning primarily in Scandinavia and Northern Europe and has only recently spread to the rest of the world. This chapter summarizes research that addresses cross-cultural and cross-national (CC/CN) occupational stress research. It begins with a discussion of typical design approaches, specifically collecting data in one country; collecting data in two or more countries, which allows comparisons of means and correlations; collecting data in multiple countries and analyzing at the country level (i.e., country means); and multilevel studies that analyze data at both the person and country level. Some studies use country as a proxy for culture (cross-national), whereas others include a cultural variable (cross-cultural). A review of the CC/CN literature found 32 studies. This literature is fragmented, making it difficult to draw firm conclusions. The review showed that even with rigorous backtranslation procedures, instruments do not always maintain psychometric properties. People in individualistic societies report higher levels of well-being, and stronger stressor-strain relationships. The same occupational stressor can manifest itself differently across countries.