bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bariatric Surgery in Adolescents A New Paradigm: Our Experience
Authors: Zavalza Juan , Prats Pedro , Giron Felipe , Nuñez Ricardo , Cantos Ivan , Molinarez Manuel , Toledo Manuel , Paipilla Omar , Zundel Natan 
Published: October 2023

Abstract

Background
Obesity in adolescent patients is a public healthcare problem that has rapidly increased over time. Surgical procedures have been proposed as a solution for this pathology, but evidence of bariatric surgery outcomes in adolescent patients is scarce. We aimed to describe the characteristics, experience, and outcomes of our institution's adolescent patients who underwent bariatric surgery in 2021.
Methods
A retrospective observational study with a prospective database was conducted. Adolescent patients who underwent bariatric procedures were included. A laparoscopic sleeve gastrectomy was performed. Baseline data and evolution were obtained and analyzed. The surgical analysis included intraoperative time, surgery, complications, and endoscopic findings. Post-operative follow-up was done for at least a 12-month period in all patients.
Results
15 adolescent patients required bariatric surgery. The mean age of the patients was 17.5 years, 13.3 % were men and 86.7 % were women. Only 1 patient had history of diabetes and sleep apnea. Mean body mass index in the group was 42.46 kg/m² before intervention and 26.66 kg/m² year after surgery. Every patient got a GERD-Q score, under 5 points. With a satisfaction rate of 100% for weight loss. No intraoperative or postoperative complications were recorded.
Conclusions
Bariatric surgery is a safe procedure for weight loss, it’s feasible, replicable, and safe for adolescent patients. Follow-up is essential to measure GERD and weight loss maintenance.
Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity
Authors: Udler Miriam , Smith Kirk , Deutsch Aaron , McGrail Caroyln , Kim Hyunkyung , Hsu Sarah , Mandla Ravi , Schroeder Philip , Westerman Kenneth , Szczerbinski Lukasz , Majarian Timothy , Kaur Varinderpal , Williamson Alice , Claussnitzer Melina , Florez Jose , Manning Alisa , Mercader Josep , Gaulton Kyle 
Published: October 2023

Abstract
We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T2D subtypes with distinct cardiometabolic trait associations. The twelve genetic clusters were distinctively enriched for single-cell regulatory regions. Polygenic scores derived from the clusters differed in distribution between ancestry groups, including a significantly higher proportion of lipodystrophy-related polygenic risk in East Asian ancestry. T2D risk was equivalent at a BMI of 30 kg/m2 in the European subpopulation and 24.2 (22.9-25.5) kg/m2 in the East Asian subpopulation; after adjusting for cluster-specific genetic risk, the equivalent BMI threshold increased to 28.5 (27.1-30.0) kg/m2 in the East Asian group, explaining about 75% of the difference in BMI thresholds. Thus, these multi-ancestry T2D genetic subtypes encompass a broader range of biological mechanisms and help explain ancestry-associated differences in T2D risk profiles.
Navigation Patterns and Design Strategies to Minimize Mobile Usability Issues
Authors: Riaz Muhammad Moiz , Faisal C.M. Nadeem , Mahmood Toqeer , Fernandez-Lanvin Daniel , Gonzalez-Rodriguez Martin , De Andrés Javier 
Published: October 2023

Abstract

Mobile devices are becoming essential in our daily lives, and people frequently start using mobile devices without fully knowing the navigation of applications, which leads to frustration. New and existing users find usability challenges while using mobile applications because of complex and unfamiliar interfaces. This paper investigates usability challenges and how users interact with WhatsApp, Facebook, and Instagram navigation patterns. Initially, Study 1 is conducted on the existing navigation of these applications, and after getting user pain points, improved navigation is designed to conduct Study 2. Study 3 compares Study 1 and Study 2 results to seek further insight. A total of 136 individuals participated in the study to assess the usability via the System Usability Scale. The results depict that the overall existing navigation of these applications is complex, which causes a lack of interest in the application and leads to ultimate frustration. When these applications were compared for navigation patterns in Study 1, huge differences were evidenced in navigation patterns, and the conclusion is that users must learn a lot before usage. In Study 2, users observed modified navigation prototypes easy to use, less complex, and less difference in navigation patterns when employed Apps compared with each other. In conclusion, modified navigation-based prototypes foster usability, learnability, and effectiveness.
Description of Nesterenkonia aerolata sp. nov., an actinobacterium isolated from air of manufacturing shop in a pharmaceutical factory
Authors: Song Ming-Hui , Ma Wen-Long , Zhang Ning , He Wei , Wang Hong-Chuan , Fan Yi-Ling , Zhang Dao-Feng , Wang Shuang 
Published: October 2023

Abstract

During our studies on the microorganism diversity from air of manufacturing shop in a pharmaceutical factory in Shandong province, China, a Gram-stain-positive, aerobic, cocci-shaped bacterium, designated LY-0111T, was isolated from a settling dish. Strain LY-0111T grew at temperature of 10–42°C (optimum 35°C), pH of 5.0–10.0 (optimum pH 7.0) and NaCl concentration of 1–12% (optimum 0.5–3%, w/v). Based on the 16S rRNA gene sequence analysis, the strain shared the highest sequence similarities to Nesterenkonia halophila YIM 70179T (96.2%), and was placed within the radiation of Nesterenkonia species in the phylogenetic trees. The draft genome of the isolate was sequenced, which comprised 2,931,270 bp with G + C content of 66.47%. A supermatrix tree based on the gene set bac120 indicated that LY-0111T was close related to Nesterenkonia xinjiangensis YIM 70097T (16S rRNA gene sequence similarity 95.3%). Chemotaxonomic analysis indicated that the main respiratory quinones were MK-7, MK-8, and MK-9, the predominant cellular fatty acids were anteiso-C15:0 and iso-C15:0, and the major polar lipids consisted of diphosphatidylglycerol, phosphatidylglycerol and phosphatidylinositol. According to the phenotypic, chemotaxonomic and phylogenetic features, strain LY-0111T is considered to represent a novel species, for which the name Nesterenkonia aerolata sp. nov. is proposed. The type strain is LY-0111T (= JCM 36375T = GDMCC 1.3945T). In addition, Nesterenkonia jeotgali was proposed as a later synonym of Nesterenkonia sandarakina, according to the ANI (96.8%) and dDDH (72.9%) analysis between them.
Patient with myeloma-related kidney disease and positivity for anti-PLA2R: a case report
Authors: Li Xiaoli , Gao Peijuan , Zhang Jian , Huang Biao , Hao Yunfei 
Published: October 2023

Abstract
Background
Autoantibody against phospholipase A2 receptor (anti-PLA2R) has been knowledge as a specific biomarker of membranous nephropathy (MN)
Case presentation:
Herein, we found a patient with nephrotic syndrome and seropositive anti-PLA2R. Additionally, she was concurrent with multiple myeloma. Renal biopsy identified no MN but MM-related crystalline nephropathy of monoclonal light chain.
Conclusions
This is the first case with serological anti-PLA2R antibodies in patients with MM-related kidney lesions and no MN. It highlights that kidney biopsy may be still required in nephrotic patients with a positive anti-PLA2R antibody test.
Biodynamic response of the seated human body to a vibrating environment: Effect of seat backrest support
Authors: Ding Wei , Wang Leizhi , Ao Hongrui , Chen Zhaobo , Yan Hui 
Published: October 2023

Abstract
This paper introduces the feature that the backrest of an ergonomic chair can provide effective support to the head, chest and waist into the vibration environment, and conducts research on whether the backrest can provide the reduction to the vibration, and the influence of its stiffness and damping on the vibration reduction influence. Four-degree-of-freedom (4-DOF) human-chair coupling models are constructed to characterize the different contact modes between the head, chest, waist and backrest. The simulation results of the biodynamic response curves of the seat-to-head (STH) transfer ratio of the model agree with the trend of the experimental results, proving its validity. With backrest support, the peak of STH curve will be reduced (the effect of supporting the waist is not obvious) and its resonance frequency will be changed. When the upper torso is in full contact with the backrest, the peak value and resonant frequency of STH curve are positively correlated with the contact stiffness of the chair surface and negatively correlated with the contact damping. For periodic and nonperiodic excitation, selection methods of the contact stiffness and damping of the backrest are proposed to reduce the transmission rate and improve comfort.
FOXD subfamily genes serve as biomarkers and therapy targets in colorectal cancer
Authors: Chen Ying , Qiao Haiyan , Zhong Ruiqi , Sun Lei , Shang Bingbing 
Published: October 2023

Abstract
Background: The forkhead box (FOX) family of proteins regulates gene transcription and expression. It regulates various biological processes, such as tumorigenesis and cell proliferation. FOXD, a subfamily of FOX, is associated with poor prognosis. However, the potential clinical value of FOXD subfamily members has not yet been elucidated.
Methods: We used The Cancer Genome Atlas Project (TCGA), which was used to analyze the HTSeq-count data, clinical data, and single-nucleotide polymorphisms (SNPS). Furthermore, we used the DESEQ2 software to detect differentially expressed genes (DEGs). Batch survival analysis was performed using the survival and survminer packages in R to obtain genes with different expression levels. The intersection of the two results was used to identify the FOXD subfamily as the principal variable. Each gene was analyzed using RT-qPCR, western blotting, and immunohistochemistry. Functional enrichment analysis of FOXD subfamily-related DEGs was performed using the ClusterProfiler package. A protein network of FOXD subfamily-related DEGs was constructed using the STRING online database. We used CIBERSORT to determine the relationship between FOXD subfamily expression and immune cell infiltration. We established a survival analysis model to explore the clinical correlation between FOXD subfamily members and CRC.
Results: In contrast to the normal tissue/cell line, FOXD1, FOXD2, FOXD3, and FOXD4 expression was higher. No FOXD1 mutations were detected. Moreover, FOXD2 was detected in both COAD and READ groups. FOXD3 and FOXD4 were onlymutated in COAD. Among the FOXD subfamily members, the AUC of FOXD3 was 0.949, indicating that FOXD3 has a high overall diagnostic accuracy for CRC. The results of the GSEA showed that the genes related to the FOXD subfamily were mainly related to the KEGG pathway, such as cytokine, cytokine, and ECM receptor interactions. Kaplan-Meier curves and nomograms showed that FOXD1, FOXD3, and FOXD4 were prognostically significant.
Conclusions: We explored the correlation between the expression of the FOXD subfamily genes and the clinical and immunological characteristics of patients with CRC. The FOXD subfamily may serve as a diagnostic and prognostic biomarker for CRC and be used as an immunotherapy target in patients with CRC.
Beast Quake (Taylor’s Version): analysis of seismic signals recorded during two Taylor Swift concerts
Authors: Caplan-Auerbach Jacqueline , Marczewski Kyla , Bullock Gavin 
Published: October 2023

Abstract
Taylor Swift concerts at Lumen Field, Seattle in July 2023 were detected seismically by an accelerometer located proximal to the stadium. The signals were nearly identical over the two nights, consistent with a repeated set list. Ground shaking is recorded in two primary frequency bands: broadband energy between 30-80 Hz, and harmonic low frequencies between 1-8 Hz. Discrete songs are clearly visible within the data, with narrow-band low frequency signals matching the published tempo of each song. Signals recorded in association with the sound check contain little to no low-frequency energy, suggesting that low frequency energy is associated with the synchronous motion of a dancing crowd. High frequency energy is observed only during songs that include a full band as opposed to solo acoustic performances by Taylor Swift. Video data provided by citizen scientists in attendance at the concerts allow us to correlate changes in seismic amplitude with observations of crowd motion. The synchronized motion of 72,000 fans created sustained energy that exceeded the iconic “Beast Quake” in 2011.
Impact of Various High Fat Diets on Gene Expression and the Microbiome Across the Mouse Intestines
Authors: Martinez-Lomeli Jose , Deol Poonamjot , Deans Jonathan R , Jiang Tao , Ruegger Paul , Borneman James , Sladek Frances M. 
Published: October 2023

Abstract
High fat diets (HFDs) have been linked to several diseases including obesity, diabetes, fatty liver, inflammatory bowel disease (IBD) and colon cancer. In this study, we examined the impact on intestinal gene expression of three isocaloric HFDs that differed only in their fatty acid composition – coconut oil (saturated fats), conventional soybean oil (polyunsaturated fats) and a genetically modified soybean oil (monounsaturated fats). Four functionally distinct segments of the mouse intestinal tract were analyzed using RNA-seq – duodenum, jejunum, terminal ileum and proximal colon. We found considerable dysregulation of genes in multiple tissues with the different diets, including those encoding nuclear receptors and genes involved in xenobiotic and drug metabolism, epithelial barrier function, IBD and colon cancer as well as genes associated with the microbiome and COVID-19. Network analysis shows that genes involved in metabolism tend to be upregulated by the HFDs while genes related to the immune system are downregulated; neurotransmitter signaling was also dysregulated by the HFDs. Genomic sequencing also revealed a microbiome altered by the HFDs. This study highlights the potential impact of different HFDs on gut health with implications for the organism as a whole and will serve as a reference for gene expression along the length of the intestines.
Associations between Caffeine Intake and the Risk of Mortality in Adults with Prediabetes: Evidence from NHANES 1999-2018
Authors: Pan Yang , Wu Yuqing , Wu Shuting , Li Ruoyu , Hong Jing , Liu Wenyue , Zhu Hong 
Published: October 2023

Abstract

Background
Prediabetes is a pre-clinical disease state, in which individuals have a higher risk of developing diabetes, cardiovascular disease, and death compared to the general population. Recent studies have shown that consuming caffeine may decrease mortality risk in people with diabetes. However, it is not clear if the same effect exists in individuals with prediabetes.
Objectives
In this study, we investigated the potential impact of caffeine intake on the risk of all-cause mortality and cardiovascular mortality in adults with prediabetes.
Methods
we analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999–2018, and the vital status of participants was tracked until December 31, 2019 using the National Death Index (NDI). Caffeine intake was measured at baseline via 24-hour dietary recall. Multivariable Cox regression analysis and subgroup analysis were conducted to examine the independent relationships among caffeine intake and mortality.
Results
After approximately 20 years of follow-up, 11,581 adults with prediabetes were included, and there were 1,892 deaths, including 497 deaths due to cardiovascular diseases. The results revealed that patients in the highest quintile of caffeine intake had significantly lower hazard ratios (HRs) and 95% confidence intervals (CIs) compared to those in the lowest quintile. Specifically, the HR for all-cause mortality was 0.70 (with a 95% CI of 0.58–0.84), and the HR for cardiovascular mortality was 0.68 (with a 95% CI of 0.46–0.99).
Conclusions
Our findings indicate a positive effect of caffeine intake on reducing the risk of all-cause and cardiovascular mortality in adults with prediabetes.
Experimental and numerical analysis of the influence of fluid-structure interactions on the dynamic characteristics of a flexible tank
Authors: Tuong Bui Pham 
Published: October 2023

Abstract
This study evaluated the effect of two-way fluid–structure interactions (FSIs) on the dynamic characteristics of flexible storage liquid tanks. A hybrid approach, combining the finite volume method (FVM) and the finite element method (FEM), denoted as FVM/FEM, was used to model the response of a flexible water tank under seismic loading. The fluid domain was simulated using FVM, while the structural domain was represented using FEM. A two-dimensional interaction equation was solved at the contact surface between an elastic tank wall and the fluid by tuning the relaxation parameter and convergence conditions. The proposed FVM/FEM model provides fundamental insights for modeling interactions two-way FSI. The model enables evaluating the effect of considering two-way FSI on the dynamic characteristics of a tank flexible to a rigid tank wall. The accuracy of the coupling FVM/FEM method was confirmed through a comparative experiment with previous studies and design code, including the quantities of natural frequency, liquid sloshing, and hydrodynamic pressure. The results showed that the frequency of flexible tank walls differed from that of rigid walls, especially the hydrodynamic pressure of liquid motion acting on the tank. The peak hydrodynamic pressure of the fluid acting on thick-walled when considering FSI is 38.2 kPa, deviating only 0.2% from the ACI standards (38.12 kPa) or 5.47% with EC8 (36.11 kPa). However, the study shows that when considering the two-way interaction for thin-walled tanks, this deviation from ACI and EC8 increases significantly to 12.2% and 16.8%, respectively. From that, the numerical results show a “threshold value” is revealed to distinguish flexible or rigid tanks. If the tank stiffness exceeds this threshold, then the thicker the tank, the lower the hydrodynamic pressure. However, if the tank stiffness is lesser, vice versa. A good agreement is observed between the numerical, analytical, published, and experimental data.
Early combination with remdesivir, nirmatrelvir/ritonavir and sotrovimab for the treatment of COVID-19 in immunocompromised hosts
Authors: Gentile Ivan , Foggia Maria , Silvitelli Maria , Sardanelli Alessia , Cattaneo Letizia , Viceconte Giulio 
Published: October 2023

Abstract
Background:
Immunocompromised patients with COVID-19 have higher morbidity and mortality than general population. Some authors have successfully used antiviral combination, but never in the early phase of the infection.
Methods:
Retrospective cohort study to describe efficacy and safety of the combination of 2 antivirals, with or without a mAb, both in early (within 10 days from symptoms) and in later phase (after 10 days) of SARS-CoV-2 infection in immunocompromised patients admitted to our facility.
Results:
We treated 11 patients (7 in early phase and 4 in later phase of COVID-19) with 10 days of intravenous remdesivir plus 5 days of oral nirmatelvir/ritonavir, also combined with sotrovimab in 10/11 cases.
Notably, 100% of the “early” patients reached virological clearance at day 30 from the end of the therapy and were alive and well at follow-up, whereas corresponding figures in the “late” patients were 50% and 75%. Patients in late group more frequently needed oxygen supplementation (p=0.015) and steroid therapy (p=0.045) during admission and reached higher a COVID-19 severity (p=0.017).
Discussion:
The combination of antiviral and sotrovimab in early phase of COVID-19 in immunocompromised patients is well tolerated and associated with 100% of virological clearance. Patients treated later have lower response rate and higher disease severity, but a causative role of the therapy in such finding is yet to be demonstrated.
Corrosion behavior and mechanism of N80 steel caused by sulfate reducing bacteria in CO2-saturated shale gas field produced water at 60℃
Authors: Chen Wen , Liu Haifeng , Wu Gui-yang , Yan Jing 
Published: October 2023

Abstract

The corrosion of steel caused by sulfate reducing bacteria (SRB) in shale gas environment is one of the big factors leading to the service failure of pipeline steel. However, the related studies of SRB corrosion especially at a high temperature are still poor. This paper aims to investigate the effects of SRB on the corrosion behavior of N80 steel in CO2-saturated simulated shale gas produced water at 60°C by weight loss, 3D microscope,electrochemical impedance spectroscopy (EIS) and polarization curves and so on. Results showed that the corrosion rate of N80 steel in the presence of SRB was greater than that of the abiotic control specimen. SRB cells and the inhibitive organics could have a competitive adsorption on the steel surface. The adsorption of inhibitive organics on steel in the abiotic condition caused a slight corrosion of the control specimen. While the adsorption of SRB cells as well as the subsequent formation of biofilm have accelerated the localized corrosion of specimen. Therefore, steel corrosion is accelerated in the presence of SRB at a high temperature.
The inclusion of the epithelium in numerical models of the human cornea
Authors: Montanino Andrea , Pandolfi Anna 
Published: October 2023

Abstract
We present a patient-specific finite element model of the human cornea that accounts for the presence of the epithelium. The thin anterior layer that protects the cornea from the external actions has a scant relevance from the mechanical point of view and it has been neglected in most numerical models of the cornea, which assign to the entire cornea the mechanical properties of the stroma. Yet, modern corneal topographers capture the geometry of the epithelium, which can be naturally included into a patient-specific solid model of the cornea, treated as a multi-layer solid. For numerical applications, the presence of a thin layer on the anterior cornea requires a finer discretization and the definition of two constitutive models (including the corresponding properties) for stroma and epithelium. In this study we want to assess the relevance of the inclusion of the epithelium in the model of the cornea, by analyzing the effects in terms of uncertainties of the mechanical properties, stress distribution across the thickness, and numerical discretization.