bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitators and barriers to parental involvement in neonatal pain management in the NICU: a scoping review
Authors: Feng Lu , Jing Jie , Shi Min , Tang Binzhi , Xie Linli 
Published: January 2025

ObjectivesNeonatal pain prevention is not only a humanistic but also an ethical imperative. Fitting with the principles of family-centred care, parental involvement in neonatal pain management plays an active role in infant development and parental well-being. However, the process of parental involvement faces constant challenges. To help structure and implement a family engagement programme in neonatal pain management in the neonatal intensive care unit (NICU), we conducted a scoping review to identify facilitators and barriers to parental involvement in neonatal pain management.MethodsWe conducted the scoping review using the Arksey and O’Malley framework. PubMed, Cochrane Library, Web of Science, CINAHL, Scopus, Wanfang database (Chinese), CNKI (Chinese), VIP database(Chinese) and SinoMed (Chinese) were searched systematically for relevant studies published in English and Chinese from inception up to October 2023. We categorised the facilitators and barriers based on the socioecological model and analysed the results thematically in each category.ResultsTen English qualitative studies were included in the final analysis. The 34 facilitators and 41 barriers extracted were grouped into 4 domains of the socioecological model framework. Of the 10 facilitator themes, the most critical theme was informational and emotional support. Of the 10 barrier themes, the most frequently reported theme was restricted policies and resources.ConclusionsOur review highlights the essential roles of intrapersonal and interpersonal factors in parental involvement in pain management while suggesting the interconnectedness of factors in various domains within the context of the socioecological model. It implies that most interventions require development and administration at both intrapersonal and interpersonal levels. Regarding the macrolevel, a broad programme with clear regulatory approaches and targeted guidelines could be developed in the future to drive innovations in NICU pain management mode.
Doing ‘detective work’ to find a cancer: how are non-specific symptom pathways for cancer investigation organised, and what are the implications for safety and quality of care? A multisite qualitative approach
Authors: Black Georgia B , Nicholson Brian D , Moreland Julie-Ann , Fulop Naomi J , Lyratzopoulos Georgios , Baxter Ruth 
Published: January 2025

BackgroundOver the past two decades, the UK has actively developed policies to enhance early cancer diagnosis, particularly for individuals with non-specific cancer symptoms. Non-specific symptom (NSS) pathways were piloted and then implemented in 2015 to address delays in referral and diagnosis. The aim of this study was to outline the functions that enable NSS teams to investigate cancer and other diagnoses for patients with NSSs.MethodsThe analysis was derived from a multisite ethnographic study conducted between 2020 and 2023 across four major National Health Service (NHS) trusts. Data collection encompassed observations, patient shadowing, interviews with clinicians and patients (n=54) and gathered documents. We used principles of the functional resonance analysis method to identify the functions of the NSS pathway and analyse their relevance to patient safety.ResultsOur analysis produced 29 distinct functions within NSS pathways, organised into two clusters: pretesting assessment and information gathering, and post-testing interpretation and management. Safety-critical functions encompassed assessing the reason for referral, deciding on a plan of investigation and estimating the remaining cancer risk. We also identified ways that teams build and maintain safety across all functions, for example, by cultivating generalist-specialist expertise within the team and creating continuity through patient navigation. Variation in practice across sites revealed targets for an NSS pathway blueprint that would foster local development and quality improvement.ConclusionsOur findings suggest that national and local improvement plans could differentiate specific policies to reduce unwarranted variation and support adaptive variation that facilitates the delivery of safe care within the local context. Enhancing multidisciplinary teams with additional consultants and deploying patient navigators with clinical backgrounds could improve safety within NSS pathways. Future research should investigate different models of generalist-specialist team composition.
Use of biodegradable stents in ERCP: lessons from a single high-volume centre
Authors: Dwarampudi Siva , Asmat Huma , Al Farsi Usama , Devlin John , Barnabas Ashley , Harrison Phillip , Reffitt David , Joshi Deepak 
Published: January 2025

ObjectivesThe Archimedes biodegradable stents (ABSs) are licensed for use in endoscopic retrograde cholangiopancreatography (ERCP). The objectives of this study were to evaluate the clinical use in both biliary and pancreatic indications in paediatric and adult populations.MethodsThis was a retrospective study of an unselected population of 132 patients who received an ABS during an ERCP over a 53-month period. Data collected included baseline characteristics, indications for ERCP and success of ABS placement. Postprocedural adverse events were also collected.Results138 ABSs were inserted into 132 patients of which 20 patients were paediatrics (60% male, median age 11.8 years). 96 pancreatic ABSs were placed (n=89 fast degradation). Fast degradation stents were used prophylactically to mitigate against pancreatitis or for a strictured pancreatic duct (PD). 42 biliary Archimedes stents were placed (n=40 slow degradation stents). Slow degradation stents were placed following stone fragmentation and for those awaiting surgical intervention.Overall, 63.6% of patients (n=84) required a pancreatic ABS to mitigate against pancreatitis as the PD was initially cannulated or contrast was injected—only 3.0% developed post-ERCP pancreatitis.97% of ABSs were placed successfully. There were no reported adverse events relating to the use of ABS.ConclusionThe ABS is safe and highly efficacious in the use of both pancreatic and biliary indications at ERCP in adult and paediatric populations. Further indications for the use of the ABS appear to be evolving in clinical practice.
Arginase-1-specific T cells target and modulate tumor-associated macrophages
Authors: Martinenaite Evelina , Lecoq Inés , Aaboe-Jørgensen Mia , Ahmad Shamaila Munir , Perez-Penco Maria , Glöckner Hannah Jorinde , Chapellier Marion , Lara de la Torre Lucía , Olsen Lars Rønn , Rømer Anne Mette Askehøj , Pedersen Ayako Wakatsuki , Andersen Mads Hald 
Published: January 2025

BackgroundArginase-1 (Arg1) expressing tumor-associated macrophages (TAMs) may create an immune-suppressive tumor microenvironment (TME), which is a significant challenge for cancer immunotherapy. We previously reported the existence of Arg1-specific memory T cells among peripheral blood mononuclear cells (PBMCs) and described that Arg-1-based immune modulatory vaccines (IMVs) control tumor growth and alter the M1/M2 macrophage ratio in murine models of cancer. In the present study, we investigated how Arg1-specific T cells can directly target TAMs and influence their polarization.MethodsMurine Arg1-specific CD4+T cells isolated from splenocytes of animals vaccinated with an Arg1-derived peptide in the adjuvant montanide were co-cultured with eitherin vitroM2-differentiated bone marrow-derived macrophages orex vivoisolated F4/80+TAMs. Human Arg1-specific CD4+T cell clones were co-cultured with Arg1-expressing TAMs generatedin vitrofrom either PBMC-derived CD14+cells or the myeloid cell lines MonoMac1 and THP-1. MHC class II-restricted Arg-1 peptide presentation by macrophages was confirmed by immunopeptidomics. T-cell-mediated changes in the macrophage immune phenotype and cytokine microenvironment were examined using flow cytometry, RT-qPCR and multiplex immunoassay. The effect of Arg1-derived peptide IMV on TAMsin vivowas assessed by multiplex gene analysis of F4/80+cells.ResultsWe show that Arg1-based IMV-mediated tumor control was linked to a decrease in multiple immunosuppressive pathways in the TAM population of the treated animals. Tumor-conditioned media (TCM) derived from Arg1-vaccinated mice induced significantly higher upregulation of MHC-II on exposed myeloid cells compared with controls. Furthermore, murine CD4+Arg1-specific T cells were able to target TAMs and effectively reprogram their phenotypeex vivoby secreting IL2 and IFNγ. Next, we established that human Arg1+TAMs present Arg1-derived peptides and are directly recognized by proinflammatory CD4+Arg1-specific T cell clones. These CD4+Arg1-specific T cells were able to reprogram TCM-conditioned macrophages as observed by increased expression of CD80 and HLA-DR.ConclusionsTAMs may be directly targeted and modulated by Arg1-specific CD4+T cells. These findings provide a strong rationale for future clinical development of Arg1-based IMVs to alter the immune-suppressive TME by reprogramming TAMs and promoting a proinflammatory TME.
Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)
Authors: Kopp Sandra L , Vandermeulen Erik , McBane Robert D , Perlas Anahi , Leffert Lisa , Horlocker Terese 
Published: January 2025

Hemorrhagic complications associated with regional anesthesia are extremely rare. The fifth edition of the American Society of Regional Anesthesia and Pain Medicine’s Evidence-Based Guidelines on regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy reviews the published evidence since 2018 and provides guidance to help avoid this potentially catastrophic complication.The fifth edition of the American Society of Regional Anesthesia and Pain Medicine’s Evidence-Based Guidelines on regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy uses similar methodology as previous editions but is reorganized and significantly condensed. Therefore, the clinicians are encouraged to review the earlier texts for more detailed descriptions of methods, clinical trials, case series and pharmacology. It is impossible to perform large, randomized controlled trials evaluating a complication this rare; therefore, where the evidence is limited, the authors continue to maintain an ‘antihemorrhagic’ approach focused on patient safety and have proposed conservative times for the interruption of therapy prior to neural blockade. In previous versions, the anticoagulant doses were described as prophylactic and therapeutic. In this version, we will be using ‘low dose’ and ‘high dose,’ which will allow us to be consistent with other published guidelines and more accurately describe the dose in the setting of specific patient characteristics and indications. For example, the same ‘high’ dose may be used in one patient as a treatment for deep venous thrombosis (DVT) and in another patient as prophylaxis for recurrent DVT. Due to the increasing ability to obtain drug-specific assays, we have included suggestions for when ordering these tests may be helpful and guide practice. Like previous editions, at the end of each recommendation the authors have clearly noted how the recommendation has changed from previous editions.
Nutrient intakes of Canadian children and adolescents at school by meal occasion and location of food preparation
Authors: Ziraldo Emily R. , Ahmed Mavra , Mulligan Christine , Sellen Daniel W. , L'Abbé Mary R. 
Published: January 2025

Canadian children consume a significant proportion of daily foods at school, do not benefit from any federal school food program, and have historically inadequate diets. Assessment of dietary intakes at school can inform policy discussions for the design, funding, and delivery of school-based nutrition interventions. The objectives were to examine the most recent nationally representative dietary intake data of Canadian children at school by (i) location of food preparation, (ii) meal occasion, and (iii) as a proportion of total daily intakes. Intake data from the first day 24 h dietary recalls of the 2015 Canadian Community Health Survey-Nutrition were examined for children 4–18 years old ( n = 1690). Intakes were reported by location of food preparation and meal occasion and were expressed as means and as a proportion of daily intake. At school, 98.6% of children consumed foods that did not require preparation, while 37.1% consumed foods prepared at home. Lunch and snacks were the meal occasions consumed most often at school, by 85.5% and 66.1% of children. Children consumed 32.6% of their daily energy intake and between 28.4% and 35.6% of daily nutrient intakes at school. School-based nutrition interventions for frequently consumed meal occasions, such as snack or lunch programs, that include foods lower in added sugar and sodium and higher in calcium, fibre, and iron may improve the health of Canadian children.
Winter diet of five sympatric ungulates in west-central Alberta, Canada—inference from DNA metabarcoding of fecal pellets
Authors: Stevenson Suzanne , Johnson Chris J. , Finnegan Laura , Rea Roy V. 
Published: January 2025

Diet is one of the determinants of ungulate ecology. However, there have been few studies of the diet of sympatric ungulates in western Canada. We used DNA metabarcoding of fecal samples to evaluate the winter diet of white-tailed deer ( Odocoileus virginianus), mule deer ( O. hemionus), moose ( Alces americanus), elk ( Cervus canadensis), and caribou ( Rangifer tarandus caribou) in west-central Alberta. We found that forbs comprised 53%–82% of the reads from plant DNA, while mosses, sedges, grasses, and shrubs made up relatively little of each ungulate’s diet. There was considerable overlap in the winter diet of the five ungulates (Horn-Morisita index = 42%–64% overlap; Bray-Curtis index = 20%–45% overlap). Moose had the most distinct diet, while elk and caribou had the least distinct. However, our analysis was restricted to a coarse taxonomic resolution (family). Lichen species were not identifiable, beyond their fungal component and a number of taxonomic assignments were difficult to rationalise given our knowledge of the diet of the five ungulate species and the ecology of west-central Alberta, Canada. DNA metabarcoding of fecal samples is efficient, but apparent limitations with the technique restrict the description and quantification of diet of the five species of ungulate that we studied.
Bound chaotic photon orbits in a magnetized Kerr–Newman spacetime
Authors: Liu Caiyu , Yang Daqi , Wu Xin 
Published: January 2025

Abstract
Unlike those in the nonmagnetized counterpart, equatorial photon effective potentials outside the horizons allow for the existence of closed pockets or potential wells corresponding to local minimum values in a magnetized Kerr–Newman spacetime of Gibbons et al. There are three bound photon orbits, which neither fall into the black hole nor escape to infinity. They are stable circular orbits, bound quasiperiodic orbits and bound chaotic orbits. The stable circular photon orbits and bound quasiperiodic photon orbits are allowed on and outside the equatorial plane, but the bound chaotic photon orbits are only allowed outside the equatorial plane. On the other hand, the photon effective potentials have potential barriers with local maximum values in the magnetized case, similar to those in the nonmagnetized case. This fact means the existence of three other photon orbits, which include the photons falling to the center, scattering to infinity and unstably circling in the center. They are not necessarily restricted to the equatorial plane, either. The six types of photon orbits are confirmed numerically via an explicit symplectic integrator and the techniques of fast Lyapunov indicators and 0–1 test correlation method. In particular, a number of bound quasiperiodic photon orbits and bound chaotic photon orbits are found. The method for finding these six types of photon orbits in the phase space will also be used as a new ray-tracing method to find the corresponding six regions on the observer’s plane and to obtain black hole shadows.
Gravitational odd-parity perturbation of a Horndeski hairy black hole: quasinormal mode and parameter constraint
Authors: Yang Zhen-Hao , Lei Yun-He , Kuang Xiao-Mei , Wang Bin 
Published: January 2025

Abstract
During the binary black hole coalescence, gravitational waves emitted at the ringdown stage can be well described by black hole perturbation theory, where the quasinormal modes (QNMs) become the important ingredient in modeling the pattern waveform. In general relativity (GR), the QNMs can be obtained from solving the Regge–Wheeler (RW) equation of a non-rotating black hole. While in Horndeski gravity, the isospectrality between the odd and even parity perturbations is broken due to the scalar field, the odd perturbation equation can be simplified into a modified RW equation from the perturbed action. In this paper, we propose a new auxiliary field and tortoise coordinate to refine the modified RW equation in Horndeski gravity, and calculate the QNM frequencies of the odd perturbation of a specific hairy black hole. We find that this proposal not only cures the superluminal propagation addressed in the previous literature, but also holds the original QNM spectrum of the odd perturbation. Moreover, our results indicate that such a Horndeski hairy black hole is stable under the odd perturbation, which is also verified by the time evolution of the perturbation. In particular, in contrast to GR, the modes with

$$\ell =2$$

ℓ
=
2

can decay faster than modes with

$$\ell >2$$

ℓ
>
2

for a certain range of the Horndeski hair, and the link between the null geodesics and QNM for the odd perturbation in the current theory is violated. We then use the ringdown QNMs to preliminarily investigate the signal-to-noise ratio (SNR) rescaled measurement error of the Horndeski hair. We obtain significant effects of the angular momentum and overtone on the error bound of the hair parameter. We hope that our findings will inspire further theoretical and phenomenological work on the testing of the no-hair theorem of black holes using gravitational wave physics.
Measurement of neutron source anisotropy using the Mini Labyrinth experimental setup
Authors: Čerba Š. , Vrban B. , Lüley J. , Blahušiak P. , Filová V. , Glavo O. , Nečas V. 
Published: January 2025

Abstract
The Institute of Nuclear and Physical Engineering at the Faculty of Electrical Engineering and Information Technology of the Slovak University of Technology in Bratislava is actively engaged in research on application of neutron sources and shielding. These neutron sources are regularly utilized for educational purposes and international research projects. Most current activities take place in the Laboratory of Reactor Physics, using Pu–Be, Am–Be, and Cf-252 neutron sources. The Mini Labyrinth is one of the most frequently used experiments. Since 2020, five versions have been developed and used for various purposes. In the previous activities of the research team, the measurements were usually compared with simulations using high-fidelity simulation codes. These comparisons identified two important effects that may influence the experiments and the simulations: room effects and source anisotropy. In this paper, we focus on determining the axial and radial anisotropy of the IBN-10 Pu–Be neutron source through two simple experiments and simulation tasks using state-of-the-art Monte Carlo simulation tools, MCNP6 and Monaco. The aim of this study is to determine the uncertainty that represents the geometry effects influencing the source emission rate.
Memória e judaísmo no processo criativo de A chave de casa: uma entrevista com Tatiana Salem Levy
Authors: Jovchelovitch Laura 
Published: January 2025

This paper presents a transcription of an interview with writer Tatiana Salem Levy, originally recorded on a Zoom meeting on October 2, 2023. The questions focus on the influence of memory and Judaism on Levy’s creative process, especially while she was writing the novel The house in Smyrna. Besides exploring this subject, Salem Levy describes other aspects of her creative process, such as the way in which she structured the novel’s chapters, her creative influences, and the conflation of real experience and imagination in fiction writing. She also reflects on what Judaism means to her personally and what the relationship between memory, literature and transgenerationality might mean for the Jewish people.
PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome
Authors: Zhou Xianming , Xu Qian , Hu Xingjian , Klenotic Philip A. , Valdivia Alejandra , Leshnower Bradley G. , Dong Nianguo , Narla Goutham , Lin Zhiyong 
Published: January 2025

BACKGROUND:
Recent studies show that hyperactivation of mTOR (mammalian target of rapamycin) signaling plays a causal role in the development of thoracic aortic aneurysm and dissection. Modulation of PP2A (protein phosphatase 2A) activity has been shown to be of significant therapeutic value. In light of the effects that PP2A can exert on the mTOR pathway, we hypothesized that PP2A activation by small-molecule activators of PP2A could mitigate AA progression in Marfan syndrome (MFS).

METHODS:
Two distinct mouse models of MFS underwent daily oral administration of small-molecule activators of the PP2A compound DT-061 to assess its therapeutic potential. Echocardiography was performed to monitor the growth of the aortic root and ascending aorta. Histological evaluation was performed to assess alterations in the vascular wall. RNA-sequencing, Western blot, and immunostaining were performed to decipher the underlying mechanisms by which DT-061 suppresses AA progression.

RESULTS:
PP2A activity decreased, while mTOR activity increased in both human and mouse aortas with MFS. Concordantly, oral administration of DT-061 increased PP2A activation, reducing aortic expansion in Marfan mice. DT-061 treatment also mitigated medial hypertrophy, elastin breakdown, and extracellular matrix deterioration in the ascending aorta, along with decreased metalloproteinase activities. Mechanistic studies suggest that DT-061 suppresses mTOR signaling and smooth muscle cell dedifferentiation, contributing to its effects on thoracic aortic aneurysm and dissection progression.

CONCLUSIONS:
These studies demonstrate a pathological role of PP2A activity loss in the cause of MFS and implicate that activation of PP2A may serve as a novel therapeutic strategy to limit MFS progression, including aortic aneurysm formation.
Minimalism and Pragmatism in a Chan Gongan Commentary: Philosophical Reflections on Tongxuan’s 100 Questions
Authors: Heine Steven , Cao Xiaohuan 
Published: January 2025

Abstract
This paper provides a translation of the first twenty-five cases of the gongan collection, Tongxuan’s 100 Questions (Tongxuan Baiwen《玄百問》), which features terse responses to Tongxuan’s queries proffered by Wansong Xingxiu along with verse comments added by his main disciple Linquan Conglun. The conciseness expressed by leading Caodong school thinkers at the dawn of the Yuan period creates a minimalist discourse replete with paradox, indirection, and deceptively artless depictions of nature to disclose a pragmatist view of realization that seeks to situate Chan as the basis for the three teachings of Confucianism, Daoism, and Buddhism.