bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pirtobrutinib: First Non-covalent Tyrosine Kinase Inhibitor for
Treating Relapsed or Refractory Mantle Cell Lymphoma in Adults
Authors: De Surya K. 
Published: October 2023

:
Mantle Cell Lymphoma (MCL) is an aggressive subtype of Non-hodgkin's
Lymphoma (NHL). Bruton Tyrosine Kinase (BTK) is a non-receptor tyrosine kinase, and
is one of the therapeutic targets for B-cell-driven malignancies. Approved covalent BTK
inhibitors such as ibrutinib, acalabrutinib, and zanubrutinib are associated with treatment
limitations due to off-target side effects and the development of C481 substitution resistance
mutations. Pirtobrutinib was approved by the US FDA on January 27, 2023, for
the treatment of relapsed or refractory mantle cell lymphoma, including the resistance to
covalent BTK inhibitors. In this perspective, physicochemical properties, synthesis, dosage
and administration, mechanism of action, pharmacodynamics, pharmacokinetics, drug
interactions, and treatment-emergent adverse events of pirtobrutinib are discussed.
Protective Roles and Therapeutic Effects of Gallic Acid in the
Treatment of Cardiovascular Diseases: Current Trends and Future
Directions
Authors: Momeni Zahra , Danesh Sepideh , Ahmadpour Mahsa , Eshraghi Reza , Farkhondeh Tahereh , Pourhanifeh Mohammad Hossein , Samarghandian Saeed 
Published: October 2023

Abstract:
Cardiovascular diseases (CVDs) are serious life-threatening illnesses and significant
problematic issues for public health having a heavy economic burden on all society
worldwide. The high incidence of these diseases as well as high mortality rates make
them the leading causes of death and disability. Therefore, finding novel and more effective
therapeutic methods is urgently required. Gallic acid, an herbal medicine with numerous
biological properties, has been utilized in the treatment of various diseases for
thousands of years. It has been demonstrated that gallic acid possesses pharmacological
potential in regulating several molecular and cellular processes such as apoptosis and autophagy.
Moreover, gallic acid has been investigated in the treatment of CVDs both in
vivo and in vitro. Herein, we aimed to review the available evidence on the therapeutic
application of gallic acid for CVDs including myocardial ischemia-reperfusion injury
and infarction, drug-induced cardiotoxicity, hypertension, cardiac fibrosis, and heart failure,
with a focus on underlying mechanisms.
Developments in Stem Cell Therapy by Utilizing Artificial Intelligence
Authors: Goyal Priyanshi , Malviya Rishabha 
Published: October 2023

Abstract:
Undifferentiated cells, known as stem cells, have the capacity to self-renew and specialise in a variety
of distinct mature and functional cell types while still retaining their original identity. For their significance
in regenerative medicine, stem cells' deep potential has been widely examined, and this work has established
the groundwork for cell-based therapeutics. With the potential to repair and restore specific organs or tissue injuries
or chronic disease situations when the body's regenerative process is insufficient to heal, regenerative
medicine is quickly advancing in healthcare. The most recent developments in stem cell-based treatments for
regenerative medicine are covered in this review, focusing on mesenchymal stem cell-based treatments because
these cells have received the most clinical research. The most recent applications of artificial intelligence
algorithms in stem cell-based therapeutics are presented, along with their limitations and potential future
applications.
Proposition of In silico Pharmacophore Models for Malaria: A Review
Authors: de Sousa Natália Ferreira , de Araújo Igor Mikael Alves , Rodrigues Teresa Carolliny Moreira Lustoza , da Silva Pablo Rayff , de Moura Jéssica Paiva , Scotti Marcus Tullius , Scotti Luciana 
Published: October 2023

:
In the field of medicinal chemistry, the concept of pharmacophore refers to the specific
region of a molecule that possesses essential structural and chemical characteristics for binding
to a receptor and eliciting biological activity. Understanding the pharmacophore is crucial
for drug research and development, as it allows the design of new drugs. Malaria, a widespread
disease, is commonly treated with chloroquine and artemisinin, but the emergence of parasite
resistance limits their effectiveness. This study aims to explore computer simulations to discover
a specific pharmacophore for Malaria, providing new alternatives for its treatment. A literature
review was conducted, encompassing articles proposing a pharmacophore for Malaria, gathered
from the "Web of Science" database, with a focus on recent publications to ensure up-to-date
analysis. The selected articles employed diverse methods, including ligand-based and structurebased
approaches, integrating molecular structure and biological activity data to yield comprehensive
analyses. Affinity evaluation between the proposed pharmacophore and the target receptor
involved calculating free energy to quantify their interaction. Multiple linear regression was
commonly utilized, though it is sensitive to multicollinearity issues. Another recurrent methodology
was the use of the Schrödinger package, employing tools such as the Phase module and
the OPLS force field for interaction analysis. Pharmacophore model proposition allows threedimensional
representations guiding the synthesis and design of new biologically active compounds,
offering a promising avenue for discovering therapeutic agents to combat Malaria.
Deciphering the Therapeutic Applications of Nanomedicine in Ovarian
Cancer Therapy: An Overview
Authors: Mathur Pooja , Bhatt Shailendra , Kumar Suresh , Kamboj Sweta , Kamboj Rohit , Rana Arpana , Kumar Harish , Verma Ravinder 
Published: October 2023

Abstract:
The majority of deadly cancers that afflict the female reproductive system occur in the
ovary. Around 1,40,000 women worldwide die from ovarian cancer each year, making it the sixth
most common cancer-associated deceases among females in the United States. Modern, cutting-edge
treatments like chemotherapy and surgery frequently produce full remissions, but the recurrence rate
is still very high. When this crippling condition is diagnosed, there are frequently few therapeutic
choices available because of how quietly it manifests.

:
Healthcare practitioners must have a fundamental grasp of the warning signs and symptoms of ovarian
cancer, as well as the imaging techniques and treatment choices available, to give the patient the
best care possible. The discipline of medical nanotechnology has gained a lot of momentum in recent
years in resolving issues and enhancing the detection and treatment of different illnesses, including
cancer.

:
This article gives a brief summary of types, risk factors and approaches to ovarian cancer treatment.
We subsequently discussed the pathophysiology of ovarian cancer with the risk factors. This review
also emphasizes the various signalling pathways involved in ovarian cancer. Our comprehensive integration
of recent findings in fundamental research in the nano arena reveals the strong interest in these
nanomedicines in ovarian cancer treatment. However, these nanomedicines still require more research,
as indicated by the comparatively small number of clinical trials ongoing. This article will
provide a reference for ovarian cancer treatment.
Natural Products and Biological Activities of Plants from Genus Morus:
2011-2023
Authors: Wang Yan-Ao , Liu Chao , Guo Xu , Zhang Meng-Qi , Sun Shutao , Sun Jin-Yue , Khan Afsar , Liu Lu , Chen Ying-Ying 
Published: October 2023

Abstract:
Species of genus Morus (family Moraceae) have been used as traditional medicinal and
edible resources since ancient times. Genus Morus has been acknowledged as a promising resource
for the exploration of novel compounds with various bioactivities. Phytochemical investigations of
the genus have led to the discovery of more than approximately 453 natural products from 2011 to
2023, mainly including flavonoids, Diels-Alder adducts, 2-arylbenzfuran, alkaloids and stilbenes.
Bioactive constituents and extracts of this genus displayed a wide range of impressive biological
properties including antidiabetic, anti-inflammatory, antioxidant, anti-cancer, hepatoprotective,
renoprotective, and some other activities. Herein, the research progress of this genus Morus from
2011 to 2023 on phytochemistry and pharmacology are systematically presented and discussed for
the first time. This current review provides the easiest access to the information on genus Morus for
readers and researchers in view of enhancing the continuity on research done on this genus.
HELLP Syndrome Developing at 14 Weeks of Gestation: An Extremely
Rare Case Report and a Literature Review
Authors: Park So Hee , Kim Hayeon , Choi Jeong In , Chung Soo-Ho , Sang Jae Hong 
Published: October 2023

Introduction:
Hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome
is a disease of pregnancy that occurs very rarely before 20 weeks of gestation. We report a case of
HELLP syndrome developing at 14 weeks and 2 days of gestation.

Case Presentation:
A 33-year-old Asian primipara at 14 weeks and 2 days of gestation visited the
emergency room with a fever and headache. Initial blood pressure was 140/70 mm Hg, temperature 38.5 C, heart rate 130 beats/min with tachycardia. Her prenatal examination has been unremarkable, and fetal ultrasonography was within normal range. The laboratory results showed low
platelet count with elevated liver enzymes, D-dimer, and fibrinogen but no sign of jaundice. Her
WBC differential suggested a bacterial infection. Thus, we diagnosed early HELLP syndrome and
immediately started conservative treatments. One day after admission, symptoms and laboratory
results showed aggravation of the disease. We performed termination, followed by dilation and
curettage for retained placenta. Her general condition improved rapidly after the operation. Placental biopsy showed both acute and chronic inflammation. She also had anticardiolipin antibody
IgM, and after discharge, she was referred to a rheumatology specialist to address the antiphospholipid syndrome issue.

Discussion:
Although the triggers of HELLP syndrome are unclear, a recent inflammatory hypothesis suggests that placenta-derived inflammatory cytokines are involved. In our case, the anti-cardiolipin antibody may have triggered microangiopathy of the placenta. Our analysis of published
HELLP cases revealed that, apart from the three diagnostic criteria, the most common abnormal
laboratory finding was antiphospholipid antibodies. Therefore, despite its rarity, if a sign of inflammation is present in a patient, it is important to consider HELLP syndrome regardless of gestational age
Marine Actinobacterial Streptomyces Sp., Mediated Synthesis of Silver
Nanoparticles: Characterization and Different Biological Properties Under
In-vitro Condition
Authors: Kamala Kannan , Kumar G.J. Jeevan , Ganapathy Dhanraj , Sundramoorthy Ashok K. , Sivaperumal Pitchiah 
Published: October 2023

Background:
Green synthesis of nanomaterials is promising as a biological source for
treating different diseases without side effects.

Methods:
In the present study, marine Streptomyces sp. was used to biosynthesize silver nanoparticles,
which were then characterized and evaluated for various therapeutic activities and A 549 breast
cancer cell line for cytotoxic evaluation.

Results:
The Surface Plasmon Resonance exhibited a peak at 434 nm, and the FT-IR spectrum of St-
AgNPs revealed the presence of secondary metabolites, which were used for stabilization and capping
processes. The St-AgNPs showed an agglomerated spherical shape with a diameter of 10–35
nm. The elemental composition was silver (60.0%), oxygen (14.9%), sodium (14.9%), and carbon
(15.0%). The St-AgNPs exhibited significant antioxidant activity in terms of DPPH 62.2 ± 2.1, H2O2
57.76 ± 2.4%, TAA 64.3±2.7, and NO 64.3 ± 2.7 at 100 μg/mL. The cytotoxic activity using A 549
Breast cancer cell line was found to be only 20 % of viable cells at 100 μg concentration. St-AgNPs
revealed good antibacterial efficacy against Streptococcus mutants, Klebsiella Sp. and Staphylococcus
aureus (MRSA).

Conclusion::
The St-AgNPs may be a good choice for antibacterial, antioxidant and cytotoxic agents
in the future with further relevant study and may be used in the field of nano biomedicine.
Immunomodulatory Effects of Combined Nicotinic Acid and Prednisolone
in Adjuvant-induced Arthritis
Authors: Mirzaaghasi Shadan , Froushani Seyyed Meysam Abtahi 
Published: October 2023

Background:
The combination of two drugs may lead to better results while reducing the
need for each medication.

Objective:
This study aimed to explore the synergistic benefits of combination therapy by subopti-mal dose of niacin (Nic.) and prednisolone (Pred.) in an experimental model of Rheumatoid arthritis (RA).

Methods:
About 50 male Wistar rats (weighing 150 - 160 grams) were randomly divided into five groups of ten, including healthy and RA groups treated with Nic. (80 mg/kg-orally), or Pred. (2 mg/kg-orally), and/or co-administration of Nic. and Pred. (half doses with each one-orally). RA was induced by the injection of complete Freund's adjuvant into the hind paw of each rat. All treatments were initiated on the fifth day following the induction and continued until day 30 post-induction.

Results:
The combined Nic. and Pred. at half doses promoted a significant regression in the severity of the established RA, which is more pronounced than full doses of either drug alone. Combination therapy promoted a reduction in some hematological and biochemical RA parameters, like neutral red uptake by phagocytic cells, myeloperoxidase, nitric oxide, and C-reactive protein, more profound than each drug alone. Combined treatment caused a greater decrease in IFN-γ expression than other treatments in the area of plantar joints. All treatments were effective in increasing the expression of the IL-10 in the area of plantar joints. Prednisolone was less effective in reducing the expression of the TNF-α in the area of plantar joints than the other group.

Conclusion:
This combination may be a useful approach to controlling RA.
An Optimal Dietary Pattern for Healthy Longevity: Scoping Differencing Review between the Mediterranean and the Japanese Diet
Authors: Vitale Elsa 
Published: October 2023

Background:
From the late 1980s to the early 1990s, micronutrients were associated
with the concept of healthy aging and it was deemed as important to recognize eating lifestyles
that better involved these healthy macronutrients.

Methods:
The present integrative differencing literature review aimed to identify correlations
between healthy longevity and both the Mediterranean (MD) and the Japanese diet (JD).

Results:
A review of the primary and secondary literature was performed by consulting Embase
and Medline (PubMed) databases. The bibliographic research focused on the critical reading of
the studies in the last ten years. A total of 10 studies, 3 belonging to Embase and 7 to PubMed,
were finally included, which exhaustively agreed with the inclusion criteria considered.

Conclusion:
In all manuscripts selected, “over” elderly participants reported good adherence to
both Mediterranean and Japanese eating behaviours, acceptable anthropometric characteristics,
active social life, and regular physical activity.
Hydrogel-based Drug Delivery System in Diabetes Management
Authors: Saharan Renu , Kaur Jaspreet , Dhankhar Sanchit , Garg Nitika , Chauhan Samrat , Beniwal Suresh , Sharma Himanshu 
Published: October 2023

Background::
It is estimated that there are over 200 million people living with diabetes
mellitus (DM) all over the world. It is a metabolic condition caused by decreased insulin action or secretion.
Diabetes Mellitus is also known as Type 2 Diabetes Mellitus. Type 1 diabetes mellitus and
type 2 diabetes mellitus are the two most common types of DM. Treatment for type 1 diabetes often
consists of insulin replacement therapy, while treatment for type 2 diabetes typically consists of oral
hypoglycemics.

Objective::
Conventional dosing schedules for the vast majority of these medications come with a
number of drawbacks, the most common of which are frequent dosing, a short half-life, and low bioavailability.
Thus, innovative and regulated oral hypoglycemic medication delivery methods have
been developed to reduce the limitations of standard dose forms.

Methods::
The studies and reviews published under the title were looked up in several databases (including
PubMed, Elsevier, and Google Scholar).

Results::
Hydrogels made from biopolymers are three-dimensional polymeric networks that can be
physically or chemically crosslinked. These networks are based on natural polymers and have an inherent
hydrophilic quality because of the functional groups they contain. They have a very high affinity
for biological fluids in addition to a high water content, softness, flexibility, permeability, and biocompatibility.
The fact that these features are similar to those of a wide variety of soft living tissues
paves the way for several potentials in the field of biomedicine. In this sense, hydrogels offer excellent
platforms for the transport of medications and the controlled release of those drugs. Additionally,
biopolymer-based hydrogels can be put as coatings on medical implants in order to improve the biocompatibility
of the implants and to prevent medical diseases.

Conclusion::
The current review focuses on the most recent advancements made in the field of using
biopolymeric hydrogels that are physically and chemically crosslinked, in addition to hydrogel coatings,
for the purpose of providing sustained drug release of oral hypoglycemics and avoiding problems
that are associated with the traditional dosage forms of oral hypoglycemics.
Mental Health and Stigmatization Linked to the COVID-19 Pandemic
Authors: Kadiri Sunil Kumar , Mundhra Shakshi , Tiwari Prashant 
Published: October 2023

Abstract:
The COVID-19 pandemic has reached an entirely new level of severity. It has jolted the
entire world and caused pervasive chaos. A significant portion of the psychological responses thus
far have been reactions to events in other countries, worries about the future, and responses to confinement. Initial and prominent responses to the pandemic in India have been appalling, with a sense
of impending and palpable danger. Concerns based on facts coexist with those based on the abundance of information and misinformation disseminated by the media, particularly social media. Even
with the stringent requirements for testing, many individuals still seek reassurance through testing.
Despite the lack of general indications for their use, they stockpile pharmaceuticals out of dread of
contracting the disease. In addition to recommendations regarding hand cleansing, there are uncertainties regarding whether to wear a mask, the type of mask to use, the distance to be maintained, and
how to disinfect surfaces. There are legitimate concerns regarding employment losses and economic
decline during and after the pandemic. Social isolation and social prejudice are not synonymous.
Maintaining a distance of 1-2 meters is permissible for security purposes. In terms of status and opportunities, everyone should be treated equally. The situation calls for a cheerful tone of speech.
Using expressions such as "the end of the world" and "the plague" is discouraged. Contamination
caused by rumors must be avoided. It is essential to promote early detection and prevention. Those
who have been afflicted with COVID-19 must share their accounts of compassion and struggle. Before COVID-19, only a minority of individuals with mental health issues were treated. According to
studies, the pandemic has widened the mental health treatment divide, and outpatient mental health
services have been particularly disrupted.
Atypical Interpersonal Problem-Solving and Resting-state Functional
Connectivity in Adolescents with Maltreatment Experience
Authors: Gerin Mattia I. , Viding Essi , Puetz Vanessa B. , Armbruster-Genc Diana J.N. , Rankin Georgia , McCrory Eamon J. 
Published: October 2023

Background:
Childhood maltreatment is associated with altered neurocognitive functioning,
which is thought to reflect, in part, adaptation to early adverse environmental experiences. However,
we continue to lack a precise mechanistic understanding linking atypical neurocognitive processing
with social functioning and psychiatric outcomes following early adversity.

Objective:
The present work investigated interpersonal problem-solving, resting-state functional connectivity
(rsFC), and mental health symptoms in adolescents with documented maltreatment experience
and explored whether altered neural function contributes in part to poorer social functioning.

Methods:
Forty adolescents (aged 12-17) with documented experiences of abuse or neglect and a carefully
matched group of 42 non-maltreated peers participated in this study that measured task-based interpersonal
problem-solving skills and rsFC.

Results:
Adolescents with maltreatment experience showed poorer interpersonal problem-solving performance,
which partly accounted for their elevated mental health symptoms. Resting-state seed-based
analyses revealed that adolescents with maltreatment experience showed a significant increase in rsFC
between medial Default Mode Network (DMN) hubs, the medial prefrontal cortex (mPFC), with a
posterior cluster, including the posterior cingulate cortex (PCC), precuneus (PCu), retrosplenial cortex
(RSC), and lingual gyrus (LG). Moderation analyses revealed that maltreatment-related increased
DMN rsFC partly accounted for poorer performance in interpersonal problem-solving.

Conclusion:
Poorer interpersonal problem-solving, partly accounted for by atypical coupling between
DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal
problem-solving represents a promising avenue to promote resilience and reduce the likelihood
of mental health disorder following maltreatment experience.
Lexical Speech Features of Spontaneous Speech in Older Persons With and Without Cognitive Impairment: Reliability Analysis
Authors: Hamrick Phillip , Sanborn Victoria , Ostrand Rachel , Gunstad John 
Published: October 2023

Abstract

Background
Speech analysis data are promising digital biomarkers for the early detection of Alzheimer disease. However, despite its importance, very few studies in this area have examined whether older adults produce spontaneous speech with characteristics that are sufficiently consistent to be used as proxy markers of cognitive status.

Objective
This preliminary study seeks to investigate consistency across lexical characteristics of speech in older adults with and without cognitive impairment.

Methods
A total of 39 older adults from a larger, ongoing study (age: mean 81.1, SD 5.9 years) were included. Participants completed neuropsychological testing and both picture description tasks and expository tasks to elicit speech. Participants with T-scores of ≤40 on ≥2 cognitive tests were categorized as having mild cognitive impairment (MCI). Speech features were computed automatically by using Python and the Natural Language Toolkit.

Results
Reliability indices based on mean correlations for picture description tasks and expository tasks were similar in persons with and without MCI (with r ranging from 0.49 to 0.65 within tasks). Intraindividual variability was generally preserved across lexical speech features. Speech rate and filler rate were the most consistent indices for the cognitively intact group, and speech rate was the most consistent for the MCI group.

Conclusions
Our findings suggest that automatically calculated lexical properties of speech are consistent in older adults with varying levels of cognitive impairment. These findings encourage further investigation of the utility of speech analysis and other digital biomarkers for monitoring cognitive status over time.