bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) BERBASIS GROUP INVESTIGATION PADA MATERI PENCEMARAN LINGKUNGAN KELAS VII SMP
Authors: Baiq Afifatul Adiyani  , Nindha Ayu Berlianti  
Published: October 2023

Tujuan penelitian ini adalah menghasilkan LKPD berbasis group investigation materi pencemaran lingkungan kelas VII SMP dan mengetahui kelayakan LKPD sebagai bahan ajar. Jenis penelitian pengembangan ini mengacu pada model pengembangan ADDIE yaitu: Analysis, Desain, Development, Implementation dan Evaluation. Akan tetapi pada penelitian ini dibatasi hanya sampai pada tahap ketiga yaitu tahap pengembangan (Development). Instrumen yang digunakan dalam penelitian ini adalah lembar validasi dan lembar kepraktisan yang berupa angket respon peserta didik. Lembar validasi digunkan untuk mengetahui kualitas LKPD yang dikembangkan, sedangkan lembar angket respon peserta didik digunakan untuk mengetahui seberapa besar respon peserta didik terhadap LKPD yang dikembangkan. Hasil penelitian ini adalah produk berupa LKPD berbasis group investigation materi pencemaran lingkungan kelas VII SMP. Dari hasil analisis instrument validasi LKPD, LKPD yang dikembangkan berkategori sangat valid dengan tingkat kevalidan 87, 41%. Tingkat kepraktisan LKPD yang diperoleh dari penilaian peserta didik sebesar 90, 98% dengan kategori sangat praktis. LKPD berbasis group investigation dalam penelitian ini layak di implmentasikan.
Kata Kunci: Lembar kerja peserta didik (LKPD), Group investigation, pencemaran lingkungan
N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats
Authors: AYAZOGLU DEMİR Elif , MENTESE Ahmet , KÜÇÜK Hatice , TÜRKMEN Nihal , DEMİR Selim , ALİYAZICIOĞLU Yüksel 
Published: October 2023

Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is the precursor of glutathione, the most important endogenous antioxidant molecule and is known for its effective antioxidant and anti-inflammatory properties. Although NAC is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-FU has not been demonstrated to date. It was therefore aimed to investigate whether NAC is therapeutic against 5-FU-induced ovotoxicity in this study for the first time.
Methods: Rats were first exposed to a single dose of 5-FU (100 mg/kg) and then treated with NAC (10 and 20 mg/kg) for three days. The oxidative stress, inflammation and apoptosis markers in ovarian tissues were also determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically.
Results: It was revealed that the levels of oxidative stress, inflammation and apoptosis biomarkers in ovarian tissue increased by 5-FU administration (p
Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats
Authors: VARLIHAN Gülce Nil , AĞRALI Ömer Birkan , YILDIRIM Hatice Selin , DEMİRCİ DELİPINAR Sibel , KURU Leyla , ÖZTÜRK ÖZENER Hafize 
Published: October 2023

Aim: The present study was aimed to evaluate radiographically the effect of orally administered vitamin D3 on guided bone regeneration in calvarial critical size defects (CSD) in rats.
Methods: Two calvarial CSD were created in 12 male Sprague-Dawley rats. One of the defects was left empty (E defect), while the other one was treated with deproteinized bovine bone graft and collagen-based resorbable membrane (GM-filled defect). Following surgical intervention, rats were randomly assigned into two groups; the control group was administered distilled water, and the test group was treated with 2 µg /kg vitamin D3 by gavage once a day for 8 weeks. Radiological images were obtained from rats on 4th and 8th weeks. The area fraction of newly formed osteoid was determined using Image Fiji Analysis Software.
Results: The percentages of area fraction in the GM-filled defects were statistically higher than the E defects in both study groups at 4th and 8th weeks (p
A New Perspective on the Evaluation of Comorbidity Indices on Survival in Non-Small Cell Lung Cancer
Authors: BAKIR KAYI Alev , MÜSELLİM Benan 
Published: October 2023

Objective: Mortality studies are interpreted by considering comorbid diseases related to the main disease. Existence, number, and type of comorbid diseases can have an important effect on prognosis. There are various comorbidity indices to include the effects of comorbid diseases in the model. With a new perspective, we aimed to emphasize the importance of evaluating the combination of comorbid diseases in cancer survival.
Methods: Retrospective cohort, data were collected from cases with Non-Small Cell Lung Cancer treated in Department of Chest Diseases. Initially, the effects of their comorbid diseases on the duration of survival were calculated with univariate analysis, then examined according to number of comorbidities, lastly their specific combinations' Hazar Ratio were calculated with Cox multivariate analysis. The most used comorbid indices in the literature were also included.
Results: Out of 247 non-small cell lung cancer (NSCLC) cases analysis, 220 (89%) were men. Median duration of follow-up was 277 days, at the end of the follow-up 197 cases had died. HR of two comorbid diseases in cases was 1.80, but 59.52 for the combination of “diabetes and interstitial lung disease” and 3.76 for “diabetes and previously cancer”. Existing comorbid indices had no significant effect on survival time (p:0.684; 0.101; 0.273; 0.567, respectively).
Conclusion: We have offered a new perspective which takes into comorbid diseases related to main disease and specially their combinations when the risk is estimated in survival research. Accurate assessments of the list of comorbid diseases related to main disease hold significant importance in advancing this field.
RANCANG BANGUN ALAT PENGERING SARANG BURUNG WALET MENGUNAKAN ARDUINO VIA SENSOR DAN TIMER
Authors: Korino Korino , Nopriadi Nopriadi 
Published: October 2023

Swallow's nest is a material that provides great benefits, especially in relation to health and also as a profitable export/import commodity. However, it is not surprising that the swallow's nest business requires a lot of capital and swallow's nest products must be of high quality. Therefore, in swallow nest processing there are several important stages such as cleaning, shaping, drying and packing. From the above process, it is clear that the scale is a measure of water content which also affects the selling price, so a swallow hatcher is needed. The drying process greatly affects the quality of the swallow product/nest. If the swallow nest is too dry, there is a decrease in the weight of the material which can be dangerous. If it is too moist, mould will form and there may also be dirt. At this stage, drying is still done manually with the help of a fan. The fan is turned on for an hour, but sometimes the workers forget to turn off the fan, causing the swallow's nest to dry too much, which also results in a waste of electricity. The design of this dryer uses a sensor to turn on the lights and a timer to determine the time needed. With this tool can help workers in managing swallow nest dryers. The existence of this tool also helps businesses to be able to dry swallow nests automatically.

Keywords: Dryer, Sensor, Timer, and Arduino
The impact of bilateral brachial-ankle pulse wave velocity difference on cardiovascular disease and all-cause mortality
Authors: Zheng Mengyi , Zhang Xinyuan , Zhao Quanhui , Chen Shuohua , Guo Xinying , Wang Chi , Jonas Jost B. , Wu Shouling , Guo Caixia 
Published: October 2023

BackgroundThis study aims to investigate the association between an elevated bilateral pulse wave velocity difference (BPWVD) and cardiovascular diseases (CVDs) and all-cause mortality.MethodsThis study included a total of 38,356 participants. A multivariable Cox proportional hazards regression was used to assess the association between high BPWVD and the increased risk of CVDs and all-cause mortality by calculating hazard ratios (HRs) with 95% confidence intervals.ResultsA total of 1,213 cases of CVDs were identified over a mean duration of 6.19 years, including 886 cases of cerebral infarction (CI), 105 cases of intracerebral hemorrhage (ICH), and 222 cases of myocardial infarction (MI), along with 1,182 cases of all-cause mortality. The median BPWVD was 42 cm/s (19–80 cm/s). After adjusting for all confounders and baseline brachial-ankle PWV (baPWV), our analysis revealed a significant correlation between a higher risk of CVDs, MI, and all-cause mortality with an increase in BPWVD per standard deviation. HRs (95% confidence interval) were found to be 1.06 (1.01–1.11), 1.11 (1.02–1.21), and 1.07 (1.04–1.10), respectively. Among the participants with higher baPWV on the left side, the HRs (95% confidence interval) were 1.08 (1.02–1.14) for CVDs, 1.27 (1.10–1.46) for incident ICH, 1.16 (1.00–1.24) for incident MI, and 1.10 (1.07–1.15) for all-cause mortality, for per standard deviation increase in BPWVD.ConclusionsOur findings reveal a significant correlation between elevated BPWVD and the risks of developing CVDs and all-cause mortality. This highlights the importance of thoroughly evaluating BPWVD as a means of detecting individuals at risk for CVDs and mortality.
Closed-chest robotic repair of mitral prolapse. Surgical technique and early results
Authors: Sandoval Elena , Morales-Rey Ignacio , Bartolozzi Luis , Pereda Daniel 
Published: October 2023

BackgroundRobotic mitral repair is generally performed with four intercostal trocars and a minithoracotomy. We describe our technique and results with a totally-thoracoscopic closed chest approach using a 12 mm valveless trocar as “working port”, without a minithoracotomy. We compared our results with this technique with a control group of robotic mitral repairs performed earlier with a minithoracotomy.MethodsReview of all patients with degenerative mitral valve disease who underwent robotic mitral valve repair surgery since December 2019 (n = 110). Patients with concomitant procedures (n = 8) were excluded. The remaining 102 patients were divided in two groups, depending on the approach used, minithoracotomy (n = 63) and totally thoracoscopic (n = 39).ResultsThere were no significant differences between groups regarding preoperative characteristics. All procedures were completed robotically as planned, and repair rate was 100%. The minithoracotomy group showed a higher percentage of leaflet resections (17.9% vs. 38.7%; p = 0.03). All surgical times were significatively reduced in the totally thoracoscopic group: Cardiopulmonary bypass (97 vs. 115 min, p = 0.0008), ischemic time (67 vs. 80 min, p = 0.0013) and total surgical time (185 vs. 225 min; p &lt; 0.00001). There were no differences in ICU length of stay (1 day, p = 0.07) but hospital length of stay was shorter in the totally thoracoscopic group (4 days; p = 0.0001). Postoperative complications were similar between groups. MR at discharge was mild or less in all cases.ConclusionsRobotic mitral repair for degenerative disease can be safely performed as a closed-chest procedure, using a 12 mm trocar as “working port” and avoiding the need for a minithoracotomy. This approach does not seem to negatively affect the quality of the procedure by any measure, providing similar excellent clinical outcomes and repair rate. All surgical times were shorter in the closed-chest group.
Hypercontractile cardiac phenotype in mice overexpressing the regulatory subunit PR72 of protein phosphatase 2A
Authors: Herting Julius R. , König Jule H. , Hadova Katarina , Heinick Alexander , Müller Frank U. , Pauls Paul , Seidl Matthias D. , Soppa Carolina , Kirchhefer Uwe 
Published: October 2023

BackgroundThe activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has been shown to be upregulated in human heart failure. However, little is known about the functions of PR72 in the myocardium.MethodsTo address this issue, we generated a transgenic mouse model with heart-specific overexpression of PP2A-PR72. Biochemical and physiological methods were used to determine contractility, Ca2+ cycling parameters, and protein phosphorylation.ResultsA 2.5-fold increase in PR72 expression resulted in moderate cardiac hypertrophy. Maximal ventricular pressure was increased in catheterized transgenic mice (TG) compared to wild-type (WT) littermates. This was accompanied by an increased shortening of sarcomere length and faster relaxation at the single-cell level in TG. In parallel with these findings, the peak amplitude of Ca2+ transients was increased, and the decay in intracellular Ca2+ levels was shortened in TG compared to WT. The changes in Ca2+ cycling in TG were also evident from an increase in the full duration and width at half maximum of Ca2+ sparks. Consistent with the contractile data, phosphorylation of phospholamban at threonine-17 was higher in TG hearts. The lower expression of the Na+/Ca2+ exchanger may also contribute to the hypercontractile state in transgenic myocardium.ConclusionOur results suggest that PP2A-PR72 plays an important role in regulating cardiac contractile function and Ca2+ cycling, indicating that the upregulation of PR72 in heart failure is an attempt to compensate functionally.
Development of Fe2O3/YSZ ceramic plates for cryogenic operation of resistive-protected gaseous detectors
Authors: Olano-Vegas L. , Pardo I. , Leardini S. , Morales M. , Carreira A. R. , Corral R. M. , González-Díaz D. , Tesi A. , Moleri L. , Azevedo C. D. R. , Carramate L. , Guitián F. 
Published: October 2023

We present a ceramic material based on hematite (Fe2O3) and zirconia stabilized with yttria at 8% molar (YSZ), that exhibits stable electrical properties with transported charge and that can be tuned to the resistivities necessary to induce spark-quenching in gaseous detectors (ρ = 109-1012 Ω⋅cm), from room temperature down to the liquid-vapor coexistence point of nitrogen (77 K). It, thus, allows covering the operating temperatures of most immediate interest to gaseous instrumentation. The ceramics have been produced in a region of mass concentrations far from what has been usually explored in literature: optimal characteristics are achieved for Fe2O3 concentrations of 75%wt (LAr boiling temperature), 35%wt (LXe boiling temperature), and 100%wt (room temperature). The nine-orders-of-magnitude enhancement observed for the electrical conductivity of the mixed phases relative to that of pure Fe2O3 is startling, however it can be qualitatively understood based on existing literature. Plates of 4 cm × 4 cm have been manufactured and, prior to this work, operated in-detector at the LXe boiling point (165 K), demonstrating spark-free operation. Illustrative results obtained for the first time on a spark-protected amplification structure (RP-WELL) at around the LAr boiling point (90 K) are now presented, too.
Effect of electronic health records on doctor-patient relationship in Arabian gulf countries: a systematic review
Authors: Tabche Celine , Raheem Mays , Alolaqi Arwa , Rawaf Salman 
Published: October 2023

BackgroundThe electronic health record (EHR) has been widely implemented internationally as a tool to improve health and healthcare delivery. However, EHR implementation has been comparatively slow amongst hospitals in the Arabian Gulf countries. This gradual uptake may be linked to prevailing opinions amongst medical practitioners. Until now, no systematic review has been conducted to identify the impact of EHRs on doctor-patient relationships and attitudes in the Arabian Gulf countries.ObjectiveTo understand the impact of EHR use on patient-doctor relationships and communication in the Arabian Gulf countries.DesignA systematic review of English language publications was performed using PRISMA chart guidelines between 1990 and 2023.MethodsElectronic database search (Ovid MEDLINE, Global Health, HMIC, EMRIM, and PsycINFO) and reference searching restricted to the six Arabian Gulf countries only. MeSH terms and keywords related to electronic health records, doctor-patient communication, and relationship were used. Newcastle-Ottawa Scale (NOS) quality assessment was performed.Results18 studies fulfilled the criteria to be included in the systematic review. They were published between 1992 and 2023. Overall, a positive impact of EHR uptake was reported within the Gulf countries studied. This included improvement in the quality and performance of physicians, as well as improved accuracy in monitoring patient health. On the other hand, a notable negative impact was a general perception of physician attention shifted away from the patients themselves and towards data entry tasks (e.g., details of the patients and their education at the time of the consultation).ConclusionThe implementation of EHR systems is beneficial for effective care delivery by doctors in Gulf countries despite some patients' perception of decreased attention. The use of EHR assists doctors with recording patient details, including medication and treatment procedures, as well as their outcomes. Based on this study, the authors conclude that widespread EHR implementation is highly recommended, yet specific training should be provided, and the subsequent effect on adoption rates by all users must be evaluated (particularly physicians). The COVID-19 Pandemic showed the great value of EHR in accessing information and consulting patients remotely.
Predictive risk factors for distant metastasis in pediatric differentiated thyroid cancer from Saudi Arabia
Authors: Parvathareddy Sandeep Kumar , Siraj Abdul K. , Annaiyappanaidu Padmanaban , Siraj Nabil , Al-Rasheed Maha , Al-Haqawi Wael , Qadri Zeeshan , Siddiqui Khawar , Al-Sobhi Saif S. , Al-Dayel Fouad , Al-Kuraya Khawla S. 
Published: October 2023

BackgroundDespite their excellent prognosis, children and young adults (CAYA) with differentiated thyroid cancer (DTC) tend to have more frequent occurrence of distant metastasis (DM) compared to adult DTC. Data about DM in CAYA from Middle Eastern ethnicity is limited.MethodsMedical records of 170 patients with DTC ≤18 years were retrospectively reviewed. Clinico-pathological factors associated with lung metastasis in CAYA, their clinical presentation and outcome were analyzed. Rick factors related to distant metastasis-free survival (DMFS) for the whole cohort were evaluated.ResultsDM was observed in 27 patients and all were lung metastasis. Lung metastasis was significantly associated with younger age (≤15 years), extrathyroidal extension (ETE), multifocal tumors, bilaterality, presence of lymph node (LN) disease and high post-operative stimulated thyroglobulin (sTg). Highest negative predictive values were seen with low post-operative sTg (97.9%), absence of LN disease (93.8%), absence of ETE (92.2%) and age older than 15 years (92.9%). Post-therapy whole body scan (WBS) identified most of the lung metastasis (21 of 27; 77.8%). Upon evaluating patients response according to ATA guidelines, excellent response was seen in only one patient, while biochemical persistence and structural persistence were seen in 11.1% (3/27) and 77.8% (21/27), respectively. Elevated post-operative sTg (&gt;10ng/ml) was the only risk factor found to be significantly associated with both biochemical persistence (with or without structural persistence (p = 0.0143)) and structural persistence (p = 0.0433). Cox regression analysis identified age and post-operative sTg as independent risk factors related to DMFS. Based on these two risk factors for DMFS, patients were divided into 3 groups: low risk (no risk factors), intermediate risk (1 risk factor) and high risk (both risk factors). 20-year DMFS rates in the low-, intermediate- and high-risk groups were 100.0%, 81.3% and 23.7% respectively (p &lt; 0.0001).ConclusionHigher suspicion for metastatic pediatric DTC should be considered in patients who are young, have LN disease, extrathyroidal extension and elevated post-operative sTg. Persistent disease, despite therapy, is very common and it appears to be related to post-operative sTg level. Hence, risk adaptive management is desirable in CAYA with DTC.
Nucleotide-level prediction of CircRNA-protein binding based on fully convolutional neural network
Authors: Shen Zhen , Liu Wei , Zhao ShuJun , Zhang QinHu , Wang SiGuo , Yuan Lin 
Published: October 2023

Introduction: CircRNA-protein binding plays a critical role in complex biological activity and disease. Various deep learning-based algorithms have been proposed to identify CircRNA-protein binding sites. These methods predict whether the CircRNA sequence includes protein binding sites from the sequence level, and primarily concentrate on analysing the sequence specificity of CircRNA-protein binding. For model performance, these methods are unsatisfactory in accurately predicting motif sites that have special functions in gene expression.Methods: In this study, based on the deep learning models that implement pixel-level binary classification prediction in computer vision, we viewed the CircRNA-protein binding sites prediction as a nucleotide-level binary classification task, and use a fully convolutional neural networks to identify CircRNA-protein binding motif sites (CPBFCN).Results: CPBFCN provides a new path to predict CircRNA motifs. Based on the MEME tool, the existing CircRNA-related and protein-related database, we analysed the motif functions discovered by CPBFCN. We also investigated the correlation between CircRNA sponge and motif distribution. Furthermore, by comparing the motif distribution with different input sequence lengths, we found that some motifs in the flanking sequences of CircRNA-protein binding region may contribute to CircRNA-protein binding.Conclusion: This study contributes to identify circRNA-protein binding and provides help in understanding the role of circRNA-protein binding in gene expression regulation.
Case Report: Durable complete response of metastatic hepatocellular carcinoma with asymptomatic hyperamylasemia to combined immunotherapy of anti-cytotoxic T lymphocyte-associated antigen 4 plus anti-programmed cell death-1 antibodies
Authors: Gao Han , Chang Rui-zhi , Chen Xiao-ping , Zhang Wan-guang , Zhang Bixiang , Luo Xin , Ding Ze-yang 
Published: October 2023

BackgroundCombined immunotherapy has shown promising results in the treatment of advanced HCC, whereas the priority population that would respond to the combined immunotherapy is still elusive. In addition, HCC with asymptomatic hyperamylasemia was not reported previously.Case presentationAn aged patient was diagnosed as HCC with BCLC stage C (bone metastasis). Notably, this patient showed asymptomatic hyperamylasemia. The patient was then enrolled in a trial evaluating combined immunotherapy of anti-PD-1 antibody sintilimab (IBI308) plus anti-CTLA-4 antibody (IBI310) in advanced HCC. After being treated with combined immunotherapy, this patient rapidly achieved complete response (CR) according to mRECIST criteria or immune partial response (iPR) according to iRECIST criteria and maintain the CR state for more than 12 months. Interestingly, serum levels of amylase and lipase in this patient were reduced after treatment.ConclusionWe reported, for the first time, a case of metastatic HCC with asymptomatic hyperamylasemia, and suggested that HCC patients with asymptomatic hyperamylasemia may benefit from combined immunotherapy of anti-CTLA-4 and PD-1 antibodies.