bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatal attractions that trigger inflammation and drive atherosclerotic disease
Authors: Sharma Hitesh , Mossman Karen , Austin Richard C. 
Published: January 2024

AbstractBackgroundAtherosclerosis is the salient, underlying cause of cardiovascular diseases, such as arrhythmia, coronary artery disease, cardiomyopathy, pulmonary embolism and myocardial infarction. In recent years, atherosclerosis pathophysiology has evolved from a lipid‐based to an inflammation‐centric ideology.MethodsThis narrative review is comprised of review and original articles that were found through the PubMed search engine. The following search terms or amalgamation of terms were used: “cardiovascular disease,” “atherosclerosis,” “inflammation,” “GRP78,” “Hsp60,” “oxidative low‐density lipoproteins,” “aldehyde dehydrogenase,” “β2‐glycoprotein,” “lipoprotein lipase A,” “human cytomegalovirus.” “SARS‐CoV‐2,” “chlamydia pneumonia,” “autophagy,” “thrombosis” and “therapeutics.”ResultsEmerging evidence supports the concept that atherosclerosis is associated with the interaction between cell surface expression of stress response chaperones, including GRP78 and Hsp60, and their respective autoantibodies. Moreover, various other autoantigens and their autoantibodies have displayed a compelling connection with the development of atherosclerosis, including oxidative low‐density lipoproteins, aldehyde dehydrogenase, β2‐glycoprotein and lipoprotein lipase A. Atherosclerosis progression is also concurrent with viral and bacterial activators of various diseases. This narrative review will focus on the contributions of human cytomegalovirus as well as SARS‐CoV‐2 and chlamydia pneumonia in atherosclerosis development. Notably, the interaction of an autoantigen with their respective autoantibodies or the presence of a foreign antigen can enhance inflammation development, which leads to atherosclerotic lesion progression.ConclusionWe will highlight and discuss the complex role of the interaction between autoantigens and autoantibodies, and the presence of foreign antigens in the development of atherosclerotic lesions in relationship to pro‐inflammatory responses.
Sydowia polyspora associated with current season needle necrosis (CSNN) on Pinus brutia Ten. in Türkiye
Authors: Beram Refika Ceyda , Demiröz Fatma 
Published: January 2024

AbstractSydowia polyspora is a common fungal species living on conifers, often occurring as an epiphyte or endophyte on asymptomatic plants and in seeds. The fungus may become pathogenic under abiotic or biotic stress conditions. It is often associated with current season needle necrosis and shoot dieback on conifer species, especially Abies spp. and Pinus spp. throughout Europe and North America. The conifer Pinus brutia is common and widely distributed in Türkiye and is frequently used in reforestation. The work described here aimed to investigate the S. polyspora associated with needle necrosis and shoot dieback in five different Pinus brutia stands located in Denizli‐Türkiye, to determine the severity of the disease and to reveal the pathogenicity of this agent in P. brutia seedlings. For this purpose, fungal isolations from symptomatic P. brutia needles were carried out in five different stands. In total, 68 S. polyspora isolates were obtained, each from a different tree from which macroscopic‐microscopic morphological characterization was made and molecular characterization was done using the internal transcribed spacer (ITS) region. BLAST analysis of the ITS sequences confirmed the identification of the isolates, with 99–100% similarity to previously reported sequences of S. polyspora. Disease incidence and severity were assessed in five P. brutia stands. The disease incidence ranged between 38% and 62% (mean = 47%) while disease severity varied among sites. Pathogenicity studies were carried out on 2‐year‐old P. brutia seedlings using obtained isolates. Infection frequency in inoculated shoots was 90%. The pathogenicity tests, followed by re‐isolation of the fungus from symptomatic shoots clearly demonstrated that S. polyspora played a role in the development of needle necrosis and shoot dieback in P. brutia stands. To the best of our knowledge, this is the first report of current season needle necrosis and shoot dieback on P. brutia caused by S. polyspora in Türkiye.
Putting women back into the early modern economy: Work, occupations, and economic development
Authors: Whittle Jane 
Published: January 2024

AbstractA dataset of just under 10,000 work tasks gleaned from court depositions that records women's as well as men's work, and unpaid as well as paid activities, prompts a reassessment of the transformation of the early modern economy and women's role within it. Rather than sectoral change in production activities with a growth of manufacturing at the expense of agriculture, the evidence suggests that work tasks changed little over time despite occupational specialization increasing. Women's labour force participation is shown to contribute 44 per cent of work in the economy, rather than 30 per cent as in previous estimates. This is partly because of the importance of commercialized housework and care work, which has been largely overlooked in existing models of the early modern economy. Turning to waged work, findings confirm that men's and women's participation in paid agricultural work were linked, with women being employed in greater numbers when men were not available. However, these trends had a strong relationship with access to land, a factor that has been neglected in comparison with demographic trends and the cost of consumables. The organization of work was transformed in the seventeenth century as the number of completely landless households increased rapidly.
Mitigating the adverse impact of coworker incivility on organizational deviance: The self‐regulatory roles of trait conscientiousness and gender
Authors: Potipiroon Wisanupong 
Published: January 2024

AbstractDespite the current knowledge about the influence of peers in the workplace, we still know relatively little about the boundary conditions that may strengthen or weaken the adverse impact of coworker‐initiated incivility on targets' behavioral outcomes. Drawing upon self‐regulation impairment theory, this study aims to shed light on the impact of coworker incivility on targets' organizational deviance (e.g., working slower and taking longer breaks) and proposes that trait conscientiousness and gender can serve as self‐regulatory resources that jointly buffer its adverse impact. Survey data were collected from 401 employees nested in 83 teams in a large public organization in Thailand. The hypotheses were tested using multilevel structural equation modeling. Two‐way interaction analyses revealed that the effect of coworker incivility on supervisor‐rated organizational deviance was less pronounced among those with high levels of conscientiousness and among female targets. Three‐way interaction effects on both self‐rated and supervisor‐rated organizational deviance were also observed. Specifically, the results showed that targets with high levels of conscientiousness, regardless of gender, showed lower tendencies to engage in organizational deviance. Conversely, among targets with low conscientiousness levels, men were most likely to engage in organizational deviance, while women were also prone to do so, albeit to a lesser extent. The present findings emphasize the importance of considering individual differences in self‐regulation when addressing the detrimental effects of incivility.
Improved cooperative Ant Colony Optimization for the solution of binary combinatorial optimization applications
Authors: Prado‐Rodríguez Roberto , González Patricia , Banga Julio R. , Doallo Ramón 
Published: January 2024

AbstractBinary combinatorial optimization plays a crucial role in various scientific and engineering fields. While deterministic approaches have traditionally been used to solve these problems, stochastic methods, particularly metaheuristics, have gained popularity in recent years for efficiently handling large problem instances. Ant Colony Optimization (ACO) is among the most successful metaheuristics and is frequently employed in non‐binary combinatorial problems due to its adaptability. Although for binary combinatorial problems ACO can suffer from issues such as rapid convergence to local minima, its eminently parallel structure means that it can be exploited to solve large and complex problems also in this field. In order to provide a versatile ACO implementation that achieves competitive results across a wide range of binary combinatorial optimization problems, we introduce a parallel multicolony strategy with an improved cooperation scheme to maintain search diversity. We evaluate our proposal (Binary Parallel Cooperative ACO, BiPCACO) using a comprehensive benchmark framework, showcasing its performance and, most importantly, its flexibility as a successful all‐purpose solver for binary combinatorial problems.
Dermoscopic features of pigmented basal cell carcinoma according to size
Authors: Wang Wei‐En , Chen Yen‐Ting , Wang Chien‐Hsing , Wang Jen‐Hung , Chang Chung‐Hsing 
Published: January 2024

AbstractBackgroundBasal cell carcinoma (BCC), the most common skin cancer in humans, requires early detection. Dermoscopy enhances diagnostic accuracy through a noninvasive approach. Pigmented BCC (pBCC) is characterized by distinctive dermoscopic features, including the presence of pigmented globules or nests. While dermoscopic features of large pBCC (size >6 mm) have been extensively studied, limited data are available on small pBCC (size ≤6 mm) and its relationship with tumor progression.MethodsDermoscopic images of histologically proven pBCCs were collected between 2014 and 2022 at Hualien Tzu Chi Hospital. Each image was analyzed for patterns of pigmentation, vasculature, and epidermal and dermal structures. Statistical analysis was performed to compare the differences according to the size and the trend during tumor progression.ResultsIn total, 135 pBCCs (48 small and 87 large) were included. Pigment structures were present in all cases. Short fine telangiectasia and small erosions constituted over 85% of the cases, showing no significant distinction between small and large pBCCs, nor any specific pattern correlating with tumor enlargement. The number of arborizing vessels, ulcerations, and shiny white structures showed an increasing trend associated with size progression. Arborizing vessels appeared when tumor size exceeded 6 mm.ConclusionsThis study provides a dynamic interpretation of the dermoscopic features of pBCC according to size enlargement. Short fine telangiectasia and small erosions are highly important features for the early diagnosis of small pBCCs. Arborizing vessels, ulceration, and shiny white structures are more frequent in large pBCCs, and they increase in association with tumor progression.
Encapsulation of tuna oil by liquid and solid self‐emulsifying delivery system: in vitro digestion and oxidative stability assessment
Authors: Klintham Pitirat , Pinket Wichchunee , Kasemwong Kittiwut , Aphibanthammakit Chutima 
Published: January 2024

SummaryTuna oil, one of the main sources of omega‐3 polyunsaturated fatty acids (omega‐3 or n‐3 PUFAs), is known to have limited bioavailability due to its hydrophobicity. Moreover, the main n‐3 PUFAs found in tuna oil, that is docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are prone to oxidation. To overcome these drawbacks, tuna oil encapsulation via liquid (LSEDS) and solid self‐emulsifying delivery system (SSEDS) was developed. Different LSEDS formulations were prepared and evaluated in terms of tuna oil droplet size and dispersibility. Accordingly, the formulation with small droplets size and narrow size distribution was selected and further developed into SSEDS by spray drying process. SSEDS was thereafter characterised concerning production yield, moisture content, size, size distribution and morphology. Furthermore, the in vitro simulated gastrointestinal model of LSEDS and SSEDS was carried out. The results showed that after intestinal digestion stage, 87% and 72% of DHA were released from LSEDS and SSEDS, respectively. Therefore, these formulations of LSEDS and SSEDS were proven their ability to enhance the bioaccessibility of DHA. Moreover, the oxidative stability of LSEDS and SSEDS formulation was investigated and compared to pure tuna oil using non‐isothermal differential scanning calorimetry (DSC) analysis under oxygen. The results showed that both LSEDS and SSEDS formulations exhibited a high oxidative resistance with a higher energy needed to induce tuna oil oxidation than pure tuna oil. The chemical and thermal stability given by LSEDS and SSEDS may be efficiently applied in food area to enhance the techno‐functional properties of hydrophobic compounds.
Exploring Visiting Artists' Dual Roles and Constraints in Art Educational Programmes
Authors: Xu Chang 
Published: January 2024

AbstractThis article investigated the multifaceted role of artists in educational programmes, focusing on the challenges they face while balancing their identity as artist‐teacher, artist teacher, artist‐educator, and artist educator. This research was conducted in two phases. Phase one interrogated the effectiveness of artists taking on dual roles as both artists and educators/teachers within international and New Zealand's educational programmes. This phase advocated for artists to embrace their original role as artists without the additional burdens of other roles. Moving to phase two, this research employed the method of document analysis to investigate the historical and current engagement of artists in students' museum education within the context of New Zealand. Historically, artists were considered as art technicians with no direct involvement in art teaching or creation. Although the current LEOTC and ELC programmes in New Zealand value artists' contributions to art education, they do not indicate artists' involvement in these two programmes. Drawing from the findings of phase one and two, the study proposed a novel model that emphasises the integration of three elements: learning environment (art museum), people (artists), and objects (artworks). This model suggested that the combined action of these three elements could lead to a transformation from teacher‐led teaching to student‐centred learning in art education. Such a transition held the potential to enrich students' educational experience through collaborative efforts between artists, museum educators, and schoolteachers, and also enhance students' interdisciplinary learning experiences.
Effects of extracellular vesicles from adipose‐derived stem cells on human keloid fibroblasts via the SOCS1/JAK2/STAT3 pathway
Authors: Ruan Hongru , Wang Jie , Shi Hui , Luan Wenkang 
Published: January 2024

AbstractBackgroundKeloid represents a benign skin tumor with many cancer‐like features. Extracellular vesicles (EVs) derived from human adipose‐derived stem cells (hADSCs) play a role in cell migration of multiple diseases.AimsThis study aimed to investigate the impact of hADSC‐EVs on human keloid fibroblasts (HKFs).MethodshADSCs were cultured to the 3rd generation, and subsequently assessed for their osteogenic, adipogenic, and chondrogenic differentiative abilities using flow cytometry, alizarin red, oil red O, and alcian blue staining techniques. hADSC‐EVs were isolated through ultracentrifugation and subsequently identified. HKFs at the 3rd generation were subjected to treatment with hADSC‐EVs to observe their endocytosis of EVs by immunofluorescence. CCK‐8, wound healing, and Transwell assays were performed to test HKF proliferation and migration. The levels of autophagy proteins, collagens, and Janus kinase 2 (JAK2) and Signal Transducer and Activator of Transcription 3 (STAT3) were determined through Western blot analysis. Suppressor of cytokine signaling 1 (SOCS1) expression was determined by RT‐qPCR and Western blot.ResultshADSC‐EVs were successfully isolated from hADSCs. PKH67‐labeled hADSC‐EVs were observed to be endocytosed by HKFs, resulting the inhibition of HKF proliferation, migration, as well as a reduction in collagen deposition. hADSC‐EVs carried SOCS1 into HKFs to suppress HKF autophagy. SOCS1 downregulation in hADSC‐EVs partially nullified the inhibitory effect of hADSC‐EVs on HKFs. hADSC‐EV‐carried SOCS1 inhibited the activation of the JAK2/STAT3 pathway. JAK2/STAT3 pathway activation partially abrogated the suppression of hADSC‐EVs on the proliferation, migration, and collagen deposition of HKF.ConclusionhADSC‐EVs carried SOCS1 into HKFs and suppressed HKF autophagy, proliferation, migration, and collagen deposition by inactivating the JAK2/STAT3 pathway.
The effect of speed sintering on the optical properties and microstructure of multi‐layered cubic zirconia
Authors: Hassan Shohdy Engy Ibrahim , Sabet Ahmed , Sherif Ashraf Hussien , Salah Tarek 
Published: January 2024

AbstractPurposeSpeed sintering was introduced to fabricate time‐efficient chairside restorations, however, its influence on the microstructure and optical properties of zirconia is still unclear. This study investigated the influence of speed sintering on the microstructure and optical properties of ultra‐translucent multi‐layered cubic zirconia.Materials and methodsUltra‐translucent cubic zirconia (Katana™ UTML; Kuraray Noritake Dental Inc., Aichi, Japan) was cut into a total of 80 specimens, twenty within each layer of the blank. The specimens were divided into 2 groups: speed and conventional sintering. The translucency parameter, opalescence, chromaticity, and color difference were recorded using a spectrophotometer. Scanning electron microscope images were used for crystallographic analysis. One‐way ANOVA and Tukey's post‐hoc test (p < 0.05) were used for data analysis.ResultsSpeed sintering significantly reduced the translucency and opalescence compared to conventional sintering excluding the opalescence of the dentin layer. Chromaticity significantly decreased with speed sintering in less chromatic layers and significantly increased in more chromatic layers. Mean color change ranged between 0.65 and 1.25 across different layers. Mean crystal size decreased with speed sintering.ConclusionsWith speed sintering, translucency, and opalescence decrease while chromaticity increases in the more chromatic layers. Additionally, no clinically perceptible color change was found compared to conventional sintering.
A visual paired associate learning (vPAL) paradigm to study memory consolidation during sleep
Authors: Schmidig Flavio Jean , Geva‐Sagiv Maya , Falach Rotem , Yakim Sharon , Gat Yael , Sharon Omer , Fried Itzhak , Nir Yuval 
Published: January 2024

SummarySleep improves the consolidation and long‐term stability of newly formed memories and associations. Most research on human declarative memory and its consolidation during sleep uses word‐pair associations requiring exhaustive learning. In the present study, we present the visual paired association learning (vPAL) paradigm, in which participants learn new associations between images of celebrities and animals. The vPAL is based on a one‐shot exposure that resembles learning in natural conditions. We tested if vPAL can reveal a role for sleep in memory consolidation by assessing the specificity of memory recognition, and the cued recall performance, before and after sleep. We found that a daytime nap improved the stability of recognition memory and discrimination abilities compared to identical intervals of wakefulness. By contrast, cued recall of associations did not exhibit significant sleep‐dependent effects. High‐density electroencephalography during naps further revealed an association between sleep spindle density and stability of recognition memory. Thus, the vPAL paradigm opens new avenues for future research on sleep and memory consolidation across ages and heterogeneous populations in health and disease.
Identification of uromodulin deposition in the stroma of perinephric fibromyxoid nephrogenic adenoma by mass spectrometry
Authors: Yoshimura Kaori , Ito Yukinobu , Suzuki Mina , Horie Masafumi , Nishiuchi Takumi , Shintani‐Domoto Yukako , Shigehara Kazuyoshi , Oshima Hiroko , Oshima Masanobu , Goto Akiteru , Nojima Takayuki , Tsuzuki Toyonori , Mizokami Atsushi , Ikeda Hiroko , Maeda Daichi 
Published: January 2024

AbstractNephrogenic adenoma (NA) is an epithelial lesion that usually occurs in the mucosa of the urinary tract. Rare cases of deep infiltrative or perinephric lesions have also been reported. Recently, NA with characteristic fibromyxoid stroma (fibromyxoid NA) has been proposed as a distinct variant. Although shedding of distal renal tubular cells due to urinary tract rupture has been postulated as the cause of NA in general, the mechanism underlying extraurinary presentation of NA and fibromyxoid stromal change in fibromyxoid NA remains unknown. In this study, we performed mass spectrometry (MS) analysis in a case of perinephric fibromyxoid NA of an 82‐year‐old man who underwent right nephroureterectomy for distal ureteral cancer. The patient had no prior history of urinary tract injury or radiation. Periodic acid‐Schiff staining‐positive eosinophilic structureless deposits in the stroma of fibromyxoid NA were microdissected and subjected to liquid chromatography/MS. The analysis revealed the presence of a substantial amount of uromodulin (Tamm−Horsfall protein). The presence of urinary content in the stroma of perinephric fibromyxoid NA suggests that urinary tract rupture and engraftment of renal tubular epithelial cells directly cause the lesion.
Species diversity of fusarioid genera associated with sweet potato in Brazil, including the description of a new species
Authors: de Mello Juliana Ferreira , da Silva Santos Ana Carla , de Queiroz Brito Amanda Cupertino , da Silva Neto José Vitorino , de Almeida Souza Ana Elisa , da Costa Antônio Félix , Gomes André Angelo Medeiros , de Souza‐Motta Cristina Maria , Lopes Ueder Pedro , Machado Alexandre Reis 
Published: January 2024

AbstractThe sweet potato is of great socioeconomic importance in Brazil and throughout the world. Among the fungal pathogens associated with root diseases of this crop, Fusarium is of particular importance due to the diversity of species, the pathogenic potential in their various hosts and their ability to survive inside plants as endophytes without apparently causing damage. The objective of this work was to identify fusarioid genera from stems and roots of symptomatic and asymptomatic plants. The identification of fungal species was based on multilocus phylogenetic analysis and morphology. A total of 51 isolates, distributed in the Fusarium incarnatum‐equiseti species complex (FIESC), Fusarium fujikuroi species complex (FFSC), Fusarium oxysporum species complex (FOSC)—with a taxonomic novelty—and Neocosmospora were identified. The pathogenicity test on roots showed that 13 of the 14 tested isolates obtained from symptomatic roots and stems and from asymptomatic stems were capable of reproducing the rot symptoms observed in the field. The confirmation of the pathogenicity of isolates from asymptomatic stems corroborates the hypothesis that these fungi can live endophytically in asymptomatic tissue and are capable of causing damage to their hosts in stress situations. This is the first report of Fusarium agrestense, Fusarium annulatum, Fusarium caatingaense, Fusarium elaeidis, Fusarium pernambucanum, Fusarium pseudocircinatum, Neocosmospora falciformis and Neocosmospora suttoniana associated with root and stem rot of sweet potato.