bluuebunny/crossref_metadata_2025_split huggingface dataset:
The The applications of the Telemedicine in Neonatology and Pediatrics. A narrative revision.
Authors: Perrotta Giulio 
Published: January 2024

BACKGROUND: "Telemedicine" was born from the combination of new communication technologies with traditional personal medical examination modalities, thus configuring a new service.
METODOLOGY: All clinical trials, meta-analyses, and randomized controlled trials on PubMed were selected through March 30, 2023, for a useful total of 62 studies, for the purpose of narrative revision.
RESULTS: In neonatology and pediatrics, there has been an increase in the last decade, especially in Italy, of remote telemedicine consultation activities (via messaging, televisiting, telemonitoring, coaching, and telehealth), especially in terms of follow-up; however, these the advantages come up against a number of limitations: a) the lack of technical knowledge of the tools used for applied telemedicine; b) the costs of supporting, operating and maintaining the material instrumental network; c) the subjective cognitive distortions of the user and/or his or her family, related to the complication or uselessness of the new technologies compared to traditional methods of health care consultation and delivery; d) the non-applicability of the new technological measures related to telemedicine in the case of medical visits that require physical contact; e) a good part of the published studies have structural errors in the construction phase of the research design, effectively vitiating the final result, as happens in the hypotheses of reduced or insufficient population sample with respect to representativeness, conflict of interest with respect to the hypotheses of publicity of the specific IT tool devised and used by the research team, and satisfaction questionnaires of dubious statistical usefulness.
CONCLUSIONS: Significant evidence emerges concerning the importance of using new information technology in the service of medicine, albeit with several practical criticalities, to ensure efficiency, effectiveness, and quality of health service, both concerning social and economic contexts, for Neonatology and Pediatrics departments.
Abordaje diagnóstico de hipogalactia para el pediatra de primer contacto
Authors: Contreras Garduño Katia Andrea 
Published: January 2024

La lactancia materna (LM) es una de las formas más eficaces para garantizar la salud de los niños. México sigue siendo uno de los países que se encuentra muy distante de las metas de desarrollo sostenible establecidas para el 2030 así como a las recomendaciones internacionales en LM. La hipogalactia o baja producción de leche es una de las principales causas de abandono a la lactancia en México. En este trabajo se revisarán los principales aspectos para el abordaje diagnóstico enfocado a una atención pediátrica de primer contacto.
Peripheral Levels of the Brain-Derived Neurotrophic Factor in Coronary Artery Disease: A Systematic Review and Meta-Analysis
Authors: Shobeiri Parnian , Behnoush Amir Hossein , Khalaji Amirmohammad , Teixeira Antonio Lucio , Rezaei Nima 
Published: January 2024

Background: Among its functions, brain-derived neurotrophic factor (BDNF) regulates endothelial and macrophage activation, possibly playing a role in atherosclerotic plaque pathophysiology. Given contradicting reports, this study sought to investigate whether blood levels of BDNF differed between patients with coronary heart disease (CHD) and controls.
Methods: We explored PubMed, Embase, Web of Science, and Cochrane Library for studies comparing BDNF blood levels in patients with CHD and controls. Random-effect meta-analysis was conducted to calculate the standardized mean differences (SMD) and 95% confidence intervals (CI). The Newcastle-Ottawa scale was used to evaluate the quality of included articles, and statistical analyses were conducted using R version 4.0.4.
Results: The final analysis comprised 12 investigations covering 1422 CHD cases and 929 controls with mean ages of 59.66±13.56 and 53.78±13.61 years, respectively. The initial analyses revealed a tendency toward low levels of BDNF in the CHD group compared with the control group (SMD= -0.41; 95% CI, -1.12 to 0.30; P=0.26). After the removal of outliers, the difference achieved statistical difference (SMD= -0.56; 95% CI, -0.93 to -0.19; P<0.01). Subgroup analysis demonstrated no significant difference between serum and plasma BDNF levels (P=0.54); however, subgroup analyses of studies investigating plasma BDNF showed that patients with CHD had significantly lower BDNF levels.
Conclusion: Serum and plasma BDNF concentrations were considerably lower in patients with CHD than in healthy controls. Further studies of higher quality are required on the potential role of BDNF as a biomarker of CHD pathophysiology and severity.
Concept of the Separation of Powers: A Look from the Shariah Point of View
Authors: Abubakar Yusuf Sani , Dorloh Sulaiman , Haji Aji Rajali 
Published: January 2024

The separation of powers is the division of the government of a state into different branches, each with its own independent powers. The purpose of a system of separation of powers is to prevent the concentration of power by providing checks and balances. This paper aims to investigate this concept from the Shariah point of view. To achieve this, the research adopts a qualitative research methodology. It is found that the principle of the separation of powers in Islamic Shariah was not clearly present at the time of the Prophet (S.A.W), as he held all three powers. After the Prophet's (S.A.W) death, the principle became clearer in the era of the caliphate, especially in the era of Caliph Omar ibn al-Khattab, who separated the judicial authority from the other state powers. However, the books of Islamic history are full of examples showing that the judges throughout the territory of the Islamic caliphate worked without interference from the rulers, even the rulers themselves were appointed by the judges and appeared before the courts. From such examples, the idea of the separation of powers has been derived.
Igualdad de género en la Ley 11/2019, de 20 de diciembre, de Cooperativas de Euskadi
Authors: Gaminde Egia Eba 
Published: January 2024

La igualdad de género es reconocida como un derecho humano fundamental con importantes consecuencias socioeconómicas, por lo que sigue siendo urgente adoptar medidas e iniciativas al respecto y la vía cooperativa puede marcar alguna diferencia en este sentido. por su especial idiosincrasia. En el presente artículo abordaremos esa especificidad, analizando las fortalezas y debilidades del modelo cooperativo frente a la igualdad de género, su especial tratamiento en la normativa autonómica y, en especial, las novedades introducidas en este ámbito por la Ley 11/2019, de Cooperativas de Euskadi. Recibido: 01 junio 2023Aceptado: 30 noviembre 2023
La identidad cooperativa en el contexto de la Ley de Cooperativas de Euskadi
Authors: De Miranda José Eduardo , Corrêa Lima Andrea 
Published: January 2024

La Declaración sobre la Identidad Cooperativa, promulgada por la Alianza Cooperativa Internacional, en el Congreso de Manchester, del 1995, presentó el concepto de sociedad cooperativa, los valores y los principios cooperativos, como elementos nucleares de la identidad cooperativa. A pesar de ello, la nueva Ley de Cooperativas de Euskadi es editada sin potencializar el sentido de la identidad de las cooperativas. En este sentido, a pesar de hacer una sencilla mención sobre los valores y principios cooperativos, pero orienta la utilización de los valores y principios cooperativos en el contexto de los programas educacionales, de todos los niveles, en la Comunidad Autónoma del País Vasco.Recibido: 28 julio 2023 Aceptado: 04 diciembre 2023
PENDEKATAN TRANSFORMATIVE LEARNING DALAM PENGEMBANGAN PROFESIONALISME GURU [TRANSFORMATIVE LEARNING APPROACH IN TEACHER PROFESSIONAL DEVELOPMENT]
Authors: Lo Sarinah 
Published: January 2024

<p>Studies indicate that many teachers who have gone through Teacher Professional Development programs demonstrate no deep change in their educational perspectives and practices. Using a systematic literature review and critical reflection lens, this study aims to provide an alternative for better teacher professional development efficacy. Based on the transformative learning framework, I propose four areas of change that include: the attitude of learning, the approach to learning, the content of learning, and the climate of learning.</p><p><strong><span id="speechify-first-word-listening-nudge-20"><span id="speechify-first-word-listening-nudge-20"><span id="speechify-first-word-listening-nudge-22"><span id="speechify-first-word-listening-nudge-22">Bahasa Indonesia Abstrak</span></span> </span></span></strong></p><p><span id="speechify-first-word-listening-nudge-20"><span id="speechify-first-word-listening-nudge-20"><span id="speechify-first-word-listening-nudge-23"><span id="speechify-first-word-listening-nudge-23">Penelitian menunjukkan bahwa</span></span></span></span> banyak guru yang mengikuti program pengembangan profesional tidak memberikan perubahan yang mendalam di dalam perspektif dan praktik pendidikan mereka. Menggunakan studi literatur yang sistematik dan refleksi kritis, penelitian ini bertujuan menawarkan alternatif pengembangan professional guru yang lebih baik. Berdasakan kerangka transformative learning, penulis menggusulkan empat area perubahan yang mencakup: sikap belajar, pendekatan pembelajaran, isi pembelajaran, dan iklim pembelajaran.</p><p> </p>
Hypoxia-induced stabilization of HIF2A promotes cardiomyocyte proliferation by attenuating DNA damage
Authors: Ali Shah R. , Nguyen Ngoc Uyen Nhi , Menendez-Montes Ivan , Hsu Ching-Cheng , Elhelaly Waleed , Lam Nicholas T. , Li Shujuan , Elnwasany Abdallah , Nakada Yuji , Thet Suwannee , Foo Roger S. Y. , Sadek Hesham A. 
Published: January 2024

Introduction: Gradual exposure to a chronic hypoxic environment leads to cardiomyocyte proliferation and improved cardiac function in mouse models through a reduction in oxidative DNA damage. However, the upstream transcriptional events that link chronic hypoxia to DNA damage have remained obscure.
Aim: We sought to determine whether hypoxia signaling mediated by the hypoxia-inducible factor 1 or 2 (HIF1A or HIF2A) underlies the proliferation phenotype that is induced by chronic hypoxia.
Methods and Results: We used genetic loss-of-function models using cardiomyocyte-specific HIF1A and HIF2A gene deletions in chronic hypoxia. We additionally characterized a cardiomyocyte-specific HIF2A overexpression mouse model in normoxia during aging and upon injury. We performed transcriptional profiling with RNA-sequencing on cardiac tissue, from which we verified candidates at the protein level. We find that HIF2A - rather than HIF1A - mediates hypoxia-induced cardiomyocyte proliferation. Ectopic, oxygen-insensitive HIF2A expression in cardiomyocytes reveals the cell-autonomous role of HIF2A in cardiomyocyte proliferation. HIF2A overexpression in cardiomyocytes elicits cardiac regeneration and improvement in systolic function after myocardial infarction in adult mice. RNA-sequencing reveals that ectopic HIF2A expression attenuates DNA damage pathways, which was confirmed with immunoblot and immunofluorescence.
Conclusion: Our study provides mechanistic insights about a new approach to induce cardiomyocyte renewal and mitigate cardiac injury in the adult mammalian heart. In light of evidence that DNA damage accrues in cardiomyocytes with aging, these findings may help to usher in a new therapeutic approach to overcome such age-related changes and achieve regeneration.
Taking antibacterial drugs without a doctor’s prescription in the Russian Federation
Authors: Chigrina V. P. , Tyufilin D. S. , Deev I. A. , Kobyakova O. S. 
Published: January 2024

Background. Antibiotic resistance is a global threat leading to ineffective treatment of many infectious diseases. One of the factors contributing to an increase in antibiotic resistance is over-the-counter sale of antibiotics.The aim of this study was to establish the sources of antibiotic prescription and to determine the prevalence of self-medication and factors that cause it.Materials and methods. The computer-assisted web interview (CAWI) methodology was used in the study. The questionnaire consisted of six blocks and 41 questions. For statistical analysis of the study results, Statistica for Windows version 10.0 and R-Studio software programs were used.Results. The study involved 2,725 people. Only 50.9% of the respondents purchased antibiotics with a prescription or got them during hospitalization. Parameters associated with over-the-counter purchase of antibiotics included female gender (odds ratio (OR) = 1.4; 95% confidence interval (CI): 1.2–1.7), lack of higher education (OR = 1.6; 95% CI: 1.3–1.9), medical education (OR = 1.7; 95% CI: 1.2–2.5), lack of awareness of a ban on over-the-counter sale of antibiotics (OR = 1.6; 95% CI: 1.3–1.9), and relying on the knowledge (opinion) of family members or acquaintances as the main sources of information about the correct use of antibiotics (OR = 2.2; 95% CI: 1.7–2.9).Conclusion. Antibiotic resistance can be reduced by propaganda and strict control over a ban on over-the-counter sale of antibiotics. It is also essential to update knowledge of medical professionals about antibacterial drugs and antibiotic resistance on a regular basis, also through raising their awareness of the development of antibiotic resistance in both patients and medical workers.
Prevalence of some internal diseases depending on the adipokine level in people under 45 years of age
Authors: Kashtanova E. V. , Polonskaya Ya. V. , Shcherbakova L. V. , Shramko V. S. , Stakhneva E. M. , Khudyakova A. D. , Sadovski E. V. , Denisova D. V. , Ragino Yu. I. 
Published: January 2024

The aim was to study the prevalence of some common internal diseases in young people of working and childbearing age, depending on the levels of adipokines.Materials and methods. The study included 1,340 people aged 25–44 years. The levels of leptin, adiponectin, adipsin, lipocalin-2, plasminogen activator inhibitor-1 (PAI-1), and resistin were determined by the multiplex analysis. Low-density lipoprotein hypercholesterolemia (LDL hypercholesterolemia), coronary artery disease (CAD), type 2 diabetes mellitus (T2DM), arterial hypertension (AH), renal dysfunction (RD), and chronic bronchitis (CB) were studied.Results. With an increase in the level of adiponectin, the prevalence of CAD increased by 8.6 times. The highest quartile of the adipsin level was characterized by an increase in the prevalence of LDL hypercholesterolemia by 12.9%, AH by 3.9%, and RD by 17.9%. The quartiles of lipolkalin-2 showed higher prevalence of LDL hypercholesterolemia, AH, and RD in Q4 compared to Q1. The prevalence of CB was associated with a decrease in the level of lipocalin-2 and was higher by 35.9% within Q1 compared to Q4. In the quartiles of PAI-1, the prevalence of T2DM and LDL hypercholesterolemia was 2 and 1.5 times higher, respectively, and the prevalence of RD was 2.5 times lower in Q4 than in Q1. In quartiles of resistin, the prevalence of LDL hypercholesterolemia, AH, and RD increased by 13–38%, while the prevalence of CB decreased by 20% in Q4, compared to Q1. The prevalence of LDL hypercholesterolemia and RD was higher within Q4 of leptin.Conclusion. The results indicate the need for further research aimed at studying the molecular mechanisms underlying the effects of adipokines. This will allow to find a combined approach to restoring normal physiological levels of adipokines, which can have a positive effect in the studied internal diseases.
Study of the immunomodulatory effect of lithium salt gamma-lactone of 2,3-dehydro-L-gulonic acid on healthy and malignant blood cells
Authors: Plotnikov E. V. , Tretyakova M. S. , Krivoshchekov S. V. , Belousov M. V. , Kolobovnikova Yu. V. 
Published: January 2024

The aim of this work was to study the immunomodulatory effects of lithium salt gamma-lactone of 2,3-dehydro-Lgulonic acid (LiAc) on healthy blood leukocytes and leukemia cells in vitro.Materials and methods. Peripheral blood lymphocytes and neutrophils obtained from healthy donors, as well as THP-1 cells (human monocytic leukemia) were used as test systems. To assess the proliferative activity, lymphocyte blast transformation was used. The antiproliferative effect was studied by the 3H-thymidine incorporation assay. Cytotoxic effects were studied using the Alamar Blue test. The effect on the phagocytic activity was studied using the method for assessing the neutrophil function during bacterial phagocytosis.Results. LiAc exerted a dose-dependent effect on target cells, including antiproliferative and cytotoxic effects on leukemia cells and a stimulating effect on neutrophils in phagocytosis.Conclusion. LiAc can be considered as a promising drug with immunomodulatory effects, including a suppressive effect on the proliferative activity of leukemia cells and a stimulating effect on immune mechanisms mediated by neutrophils and macrophages.
U–Pb Age and Mineral Inclusions in Zircon from Diamondiferous Garnet–Pyroxene Rocks of the Kumdy-Kol Microdiamond Deposit in Northern Kazakhstan
Authors: Ilyin A.A. , Shatsky V.S. , Ragozin A.L. 
Published: January 2024

Abstract
––This paper describes the results of studying inclusions and determining the U–Pb age in zircon from the diamondiferous garnet–pyroxene rock of the Kumdy-Kol metamorphogenic diamond deposit, located in the Kokchetav subduction-collision zone. The distribution of rare earth elements in garnet and clinopyroxene is used as a basis for estimating the equilibrium pressure (5.5 ± 0.3 GPa) and temperature (993 ± 24 °C), which correspond to the diamond stability field. The composition of mineral inclusions in zircon indicates its formation at both the progressive and the regressive stage of metamorphism. The concordia diagram shows that the figurative points of zircon lie on a discordia with an upper intersection at 1953 ± 139 Ma and a lower intersection at 512 ± 4 Ma. The main peak on the graph of the probability density distribution of zircon ages corresponds to an age of 519 Ma. The presence of grossular–almandine garnet inclusions in zircon confirms the previous assumption that the basement rocks of the Kokchetav massif act as protoliths of garnet–pyroxene rocks.
Impact of international deployments on epidemic response in low- and middle-income countries (LMICs): A mixed-methods systematic review protocol
Authors: Haque Farhana , Bigirimana Radjabu , Glazik Rosanna , Clery Elizabeth , Kamara Neema , Aragaw Merawi , Nzegwu Femi 
Published: January 2024

Abstract
Background: Substantial resources are invested globally for deploying personnel with technical and operational skillsets to support outbreak response in the low- and middle-income countries (LMICs). In deploying to a country there is an underlying commitment to strengthen national outbreak response capacity. However, eliciting specific impacts of an international deployment on enhancing a country’s outbreak response, readiness, and preparedness capacities remain a challenge. This review examines how deployments contribute to containing public health threats in LMICs. Specifically, this review aims to: (i) explore the different international deployment models and/or approaches; (ii) identify and describe the impacts of international deployments to support national outbreak preparedness, readiness and response; and (iii) identify the facilitators and the barriers to improving public health emergency response and recovery capacities of the LMICs.
Methods: The reviewers will search the following databases for peer-reviewed articles published between January 2012 and June 2023: MEDLINE, Embase, Global Health, Globus Index Medicus, Web of Science and Google Scholar using Medical Subject Headings (MeSH) and keywords. ReliefWeb and websites of relevant humanitarian and health organisations will be searched for grey literature. The identified articles will be assessed for meeting the eligibility criteria. Two independent reviewers will screen the titles and abstracts and review the full texts of the selected articles. A customised data extraction form will be utilised. The quality of included peer-reviewed articles will be assessed using the Quality Assessment with Diverse Studies (QuADS)appraisal tool. Grey literature will be assessed using the AACODS checklist. Results from eligible articles will be analysed qualitatively using thematic synthesis. Descriptive statistics will be generated to summarise quantitative results. A parallel-results convergent synthesis approach will be used to narratively triangulate the qualitative and the quantitative findings. The results will be reported according to the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement and synthesis without meta-analysis (SWiM) guideline.
Discussion: This systematic review will identify the contributions of international deployments in improving LMICs’ public health emergency response capacities. The findings may help to refine international assistance strategies to support outbreak response efforts in the LMICs.
Systematic review registration:PROSPERO CRD42023404346
Global distribution and biodiversity of brachyuran crabs in the Persian Gulf
Authors: Hashemian Nima , Naderloo Reza , Shahdadi Adnan , Saeedi Hanieh 
Published: January 2024

Abstract
The tropical Indo-West Pacific (IWP) is one of the species-rich and high endemicity hotspots around the East Indies Triangle. However, recent research demonstrates that peripheral regions may act as evolutionary incubators, sharing unique genetic lineages with other regions of the IWP. The Persian Gulf is a shallow semi-enclosed marginal sea basin characterized by geological history, stressful environmental conditions, and intermittent connection with the Indian Ocean during the Pleistocene glacial periods. Understanding the global distribution and importance of environmental variables in shaping species richness patterns of brachyuran crabs in this region is necessary for comprehending evolutionary and ecological processes, as well as conservation priorities. We merged our own distribution dataset of 261 species of brachyuran crabs in the Persian Gulf and Gulf of Oman with the GBIF and OBIS open-access biodiversity datasets, which lack the data from this region. QGIS 3.24.3 and R 4.2.2 packages were used for data analysis and visualization of the distribution records. The highest sampling effort (1,955), species richness (225 spp.) and ES50 (expected number of species) (40.94), along with 21 endemic species of brachyuran crabs were observed in the Persian Gulf. Distribution and species richness of brachyuran crabs significantly increased with temperature (°C) and calcite (mol.m-3), and decreased with dissolved oxygen (mol.m-3), and nitrate (mol.m-3), the focus of this study. This study suggested that the Persian Gulf, as a peripheral region, may play a role in shaping brachyuran diversity and current species distribution. This highlights the importance of prioritizing marine protected areas and establishing species management in this economically and ecologically important region.