bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Arbeits- und Beschäftigungssituation von psychisch
erkrankten Menschen mit ambulanter Wohnunterstützung: Eine Auswertung
gemeindepsychiatrischer Routinedaten
Authors: Dehn Lorenz B , Suer Julia , Klein Rüdiger , Driessen Martin 
Published: November 2023

Zusammenfassung
Ziel der Studie Aufgrund bislang kaum vorliegender systematischer Daten
zur beruflichen Teilhabesituation schwer psychisch und
abhängigkeitserkrankter Menschen in der Eingliederungshilfe erfolgte
eine Auswertung gemeindepsychiatrischer Routinedaten.
Methodik Bezugsmitarbeitende füllten einen kurzen Erhebungsbogen
zu unterschiedlichen Berufs- und Beschäftigungsaspekten ihrer
Klient*innen mit wohnbezogener Assistenz in der eigenen
Häuslichkeit aus. Neben deskriptiven und explorativen Analysen dieser
Querschnittsdaten wurden zusätzlich auch die Gesamtergebnisse
früherer Erhebungsdurchgänge ausgewertet.
Ergebnisse Es konnten N=1418 Personen (M=47.6 Jahre)
berücksichtigt werden, von denen rund 45% über keinerlei
Arbeit, Beschäftigung oder tagesgestaltendes Angebot verfügten.
Dieser Anteil ist im Verlauf der letzten Jahrzehnte nahezu unverändert
geblieben.
Schlussfolgerung Insgesamt besteht dringender Handlungsbedarf
bezüglich der Verbesserung von beruflichen Teilhabechancen für
schwer psychisch und abhängigkeitserkrankte Menschen.
Does corporate sustainability disclosure mitigate earnings management: empirical evidence from Jordan
Authors: Alodat Ahmad Yuosef , Al Amosh Hamzeh , Alorayni Osamah , Khatib Saleh F. A. 
Published: November 2023

AbstractThis paper aims to investigate the relationship between sustainability disclosure practices and earnings management in the Jordanian context. Based on an analysis of 66 non-financial firms listed on ASE, spanning the period of 2017–2020. The findings revealed that companies' compliance with the disclosure of sustainability improves their ethical behavior, which limits earnings management practices and increases the reliability of their financial statements. The findings have implications for regulators, corporate executives, practitioners, policymakers, top management, and business partners. More corporate sustainability practices present more trustworthy information and more sustainable performance of the economic. To the best of the authors’ knowledge, this is the first study to examine the relationship between the extent of sustainability disclosure and earnings management in Jordanian firms. Moreover, two models were used for earnings management, which adds value to the existing literature.
Identifying key spreaders in complex networks based on local clustering coefficient and structural hole information
Authors: Wang Hao , Wang Jian , Liu Qian , Yang Shuang-ping , Wen Jun-jie , Zhao Na 
Published: November 2023

Abstract
Identifying key spreaders in a network is one of the fundamental problems in the field of complex network research, and accurately identifying influential propagators in a network holds significant practical implications. In recent years, numerous effective methods have been proposed and widely applied. However, many of these methods still have certain limitations. For instance, some methods rely solely on the global position information of nodes to assess their propagation influence, disregarding local node information. Additionally, certain methods do not consider clustering coefficients, which are essential attributes of nodes. Inspired by the quality formula, this paper introduces a method called Structural Neighborhood Centrality (SNC) that takes into account the neighborhood information of nodes. SNC measures the propagation power of nodes based on first and second-order neighborhood degrees, local clustering coefficients, structural hole constraints, and other information, resulting in higher accuracy. A series of pertinent experiments conducted on 12 real-world datasets demonstrate that, in terms of accuracy, SNC outperforms methods like CycleRatio and KSGC. Additionally, SNC demonstrates heightened monotonicity, enabling it to distinguish subtle differences between nodes. Furthermore, when it comes to identifying the most influential Top-k nodes, SNC also displays superior capabilities compared to the aforementioned methods. Finally, we conduct a detailed analysis of SNC and discuss its advantages and limitations.
Comment on ‘Ultradense protium p(0) and deuterium D(0)and their relation to ordinary Rydberg matter: a review’ (2019 Physica Scripta
94 075005)
Authors: Hansen Klavs , Engelen Jos 
Published: November 2023

Abstract
The article by Holmlid and Zeiner-Gundersen (2019 Physica Scripta
94 075 005) contains a number of claims on the production and properties of a new state of matter, referred to as ultra-dense hydrogen (UDH). These claims are very far reaching as they include the observation of processes violating the conservation of baryon number (not observed before in spite of decades of dedicated efforts); furthermore the structure assigned to UDH is not consistent with quantum mechanics, in particular with the concept of kinetic energy operators and the Heisenberg indeterminacy relations. No independent experimental confirmation on production and properties of UDH has been published, whilst possible explanations in terms of instrumental artefacts have been put forward.
Eliciting calcium transients with UV nanosecond laser stimulation in adult patient-derived glioblastoma brain cancer cells in vitro
Authors: Mellor Nicholas G , Chung Sylvia A , Graham E Scott , Day Bryan W , Unsworth Charles P 
Published: November 2023

Abstract

Objective. Glioblastoma (GBM) is the most common and lethal type of high-grade adult brain cancer. The World Health Organization have classed GBM as an incurable disease because standard treatments have yielded little improvement with life-expectancy being 6–15 months after diagnosis. Different approaches are now crucial to discover new knowledge about GBM communication/function in order to establish alternative therapies for such an aggressive adult brain cancer. Calcium (Ca2+) is a fundamental cell molecular messenger employed in GBM being involved in a wide dynamic range of cellular processes. Understanding how the movement of Ca2+ behaves and modulates activity in GBM at the single-cell level is relatively unexplored but holds the potential to yield opportunities for new therapeutic strategies and approaches for cancer treatment. Approach. In this article we establish a spatially and temporally precise method for stimulating Ca2+ transients in three patient-derived GBM cell-lines (FPW1, RN1, and RKI1) such that Ca2+ communication can be studied from single-cell to larger network scales. We demonstrate that this is possible by administering a single optimized ultra-violet (UV) nanosecond laser pulse to trigger GBM Ca2+ transients. Main results. We determine that 1.58 µJ µm−2 is the optimal UV nanosecond laser pulse energy density necessary to elicit a single Ca2+ transient in the GBM cell-lines whilst maintaining viability, functionality, the ability to be stimulated many times in an experiment, and to trigger further Ca2+ communication in a larger network of GBM cells. Significance. Using adult patient-derived mesenchymal GBM brain cancer cell-lines, the most aggressive form of GBM cancer, this work is the first of its kind as it provides a new effective modality of which to stimulate GBM cells at the single-cell level in an accurate, repeatable, and reliable manner; and is a first step toward Ca2+ communication in GBM brain cancer cells and their networks being more effectively studied.
Auxetic meta-materials and their engineering applications: a review
Authors: Liu Yangzuo , Zhao Changfang , Xu Cheng , Ren Jie , Zhong Jianlin 
Published: November 2023

Abstract
Auxetic or negative Poisson’s ratio (NPR) materials and structures are exemplary mechanical meta-materials, possessing greater energy absorption capacity, stronger indentation resistance, and other advantages. Due to their unique indentation resistance, auxetic meta-materials have tremendous potential for use in impact engineering applications. To unveil the categories, characteristics, and applications of auxetic meta-materials, this study expounded upon the basic principles of auxeticity at the structural level and its associated mechanical properties. Additionally, it outlined the typical applications within the fields of medicine, automotive manufacturing, protective gear, and garments. The auxetic honeycomb structures of interest were first classified into three types: re-entrant, chiral, and rotational rigid structures. The auxetic mechanism and mechanical properties of these structures were then discussed and compared. Furthermore, by examining their current applications and characteristics of these structures, development directions for auxetic meta-materials were highlighted to meet future engineering demands for multi-functionality.
Transition metal (Ni,Mn) codoped Zn3P2 nanoparticles: effect on structural, optical and magnetic properties
Authors: Praveenkumar Nakka , Rao Nasina Madhusudhana 
Published: November 2023

Abstract
This work reports the pure matrix and synthesis of Zn(3–(x+y))NixMnyP2 (x = 0.02, y = 0.01, 0.03, 0.05, and 0.07) nanoparticles using the solid-state reaction method. The impact of Ni-Mn codoping on the structural, morphological, chemical identification, optical, photoluminescence, and magnetic properties of Zn3P2 nanoparticles is studied. The structural properties after doping confirm the absence of other phases and synthesized samples had a tetragonal structure. Using SEM with EDAX, the nanoparticles’ surface morphology, and elemental composition are investigated. The nanoparticles have a spherical shape and approximately the expected stoichiometric atomic ratio. The optical band gap of the undoped and codoped nanoparticles is calculated and found the band gap increased with increasing dopant content. The emission peaks show that all emission peaks are in the same wavelength position with effect of dopant level. VSM confirmed the magnetic moment is found to increase with an increase in dopant concentration.
A rare presentation of mycotic cerebral aneurysm, subarachnoid haemorrhage, and mitral valve aneurysm in left-sided lnfective endocarditis: a case report and literature review
Authors: Abbas Ahmed A M , Brown Pamela F , White Ralph W 
Published: November 2023

Abstract

Background
Infective endocarditis (IE) can present as a syndromic-like condition with multisystem involvement; this can make early diagnosis particularly challenging. Rarely, left-sided IE can lead to mitral valve aneurysm formation. Showering of septic emboli to the cerebral circulation may result in a mycotic aneurysm that can rupture, leading to haemorrhagic stroke, as in this case.

Case summary
A 28-year-old male presented with a triad of subarachnoid haemorrhage (SAH) from mycotic cerebral aneurysm rupture, left-sided aortic and mitral valve IE causing severe regurgitation and aorto-mitral curtain fistula and mitral valve aneurysm formation. The SAH was the main initial presentation and was immediately treated with coiling by an interventional radiologist. However, the patient later developed heart failure due to severe aortic and mitral valve regurgitation that led to the diagnosis of IE. The patient underwent aortic and mitral valve replacements procedure10 days after SAH presentation. He then recovered satisfactorily from the operationa and successfully discharged home after completeing his course of intravenous antibiotics.

Discussion
In this article, we shed some light on this unusual syndromic presentation, elaborate on the underlying mechanism, the ultimate importance of clinical examination, pitfalls in diagnosis, the important role of the heart team in IE, and finally the timing of surgery after SAH.
Effects of inhaled seralutinib on right ventricular-pulmonary arterial (RV-PA) coupling and right heart function in pulmonary arterial hypertension (PAH)
Authors: Frantz R , Tello K , Moles V M , Solomon S D , Cravets M , Osterhout R , Bruey J M , Roscigno R F , Aranda R , Vachiery J L , Badagliacca R , Benza R L , Mclaughlin V V , Zisman L S , Ghofrani H A 
Published: November 2023

Abstract

Background
Impaired RV-PA coupling portends a poor prognosis in PAH, and right ventricular free wall strain/systolic pulmonary artery pressure (RVFWS/sPAP) has been reported as a measure of RV-PA coupling. Furthermore, increased RVFWS and right atrial area (RAA), as well as decreased pulmonary artery compliance (PAC) are associated with increased mortality risk in PAH. Seralutinib is a novel, small molecule kinase inhibitor that targets PDGFR, CSF1R, and c-KIT administered via dry powder inhaler. TORREY, a phase 2, double-blind, randomised, placebo-controlled study of inhaled seralutinib in patients with PAH (NCT04456998) met its primary endpoint, demonstrating a significant reduction in pulmonary vascular resistance (PVR) from baseline (BL) to Week 24 compared to placebo. In addition, seralutinib significantly decreased NT-proBNP.

Purpose
To test the hypothesis that seralutinib would improve RVFWS/sPAP and other measures of right heart function after 24 weeks of treatment compared to placebo in the TORREY study.

Methods
Eighty-six patients with WHO Group 1 PH (Functional Class II, III), ages ≥18 years, pulmonary vascular resistance ≥400 dyne*s/cm5, and on stable PAH standard of care therapy (the majority of whom were on double and triple therapy with approved PAH medications) were enrolled. Right heart catheterisation (RHC) and full echocardiography were performed at BL and Week 24 and at BL, Week 12, and Week 24, respectively; both were analysed in a blinded central laboratory. To calculate RVFWS/sPAP, the pulmonary artery systolic pressure from RHC was used. PAC was calculated from RHC data with the formula (SV/(PAS-PAD)). Statistical analysis was performed using ANCOVA.

Results
At Week 24, the change in RVFWS/sPAP was lower in the seralutinib group compared to placebo (Table). The changes in RVFWS and RAA were lower in the seralutinib group vs placebo at Week 12 and Week 24 (Table). Change in NT-proBNP correlated with change in RAA (r = 0.43). At Week 24, change in PAC was greater in the seralutinib group (-0.02 ± 0.085 placebo, 0.19 ± 0.089 seralutinib; LSMD 0.22 (0.104) p = 0.04). There was no effect of seralutinib on left ventricular ejection fraction.

Conclusion
Treatment with seralutinib was associated with a significant reduction of RVFWS/sPAP. In addition, significant differences in RVFWS itself, RAA, and PAC were observed. These treatment effects support improved RV-PA coupling and right heart function. In conjunction with concordant reductions in PVR and NT-proBNP, these data suggest potential favourable effects of seralutinib in PAH. Seralutinib is in clinical development as a potential new treatment option for patients with PAH.
The Complementarity Paradigm: Tracing the Transitional Justice Blueprint in the Inter-American System of Human Rights
Authors: Muñoz Rincón Anamaría 
Published: November 2023

ABSTRACT∞
The promotion of ‘home-grown’ approaches to transitional justice is a powerful trope animating the field, encouraging local ownership of transitional justice processes, and refusing ‘one size fits all’ formulas. I challenge this account by exploring how the obligations resulting from anti-impunity’s advent yield only one particular institutional design that seems compatible with obligations under the American Convention on Human Rights. This means that the state’s autonomy to institutionally design a transition is increasingly narrowed in the Inter-American System of Human Rights. I develop this argument by exploring how the right to truth is enforced, showing that the interaction between regional obligations and truth as a right yields a specific transitional institutional blueprint. In doing so, I unpack legal techniques that assist in framing as necessary a transitional justice model that is a contingent, and reckon with its implications.
The Academic Market and The Rise of Universities in Medieval and Early Modern Europe (1000–1800)
Authors: de la Croix David , Docquier Frédéric , Fabre Alice , Stelter Robert 
Published: November 2023

Abstract
We argue that market forces shaped the geographic distribution of upper-tail human capital across Europe during the Middle Ages, and contributed to bolstering universities at the dawn of the Humanistic and Scientific Revolutions. We build a unique database of thousands of scholars from university sources covering all of Europe, construct an index of their ability, and map the academic market in the medieval and early modern periods. We show that scholars tended to concentrate in the best universities (agglomeration), that better scholars were more sensitive to the quality of the university (positive sorting) and migrated over greater distances (positive selection). Agglomeration, selection, and sorting patterns testify to an integrated academic market, made possible by the use of a common language (Latin).
Complete resection versus functional preservation in resection of cystic vestibular schwannoma in a 56-year-old female: case report and literature review
Authors: Golden Nyoman , Awyono Steven , Prakoso Dicky T , Lauren Christopher 
Published: November 2023

Abstract
Surgery for vestibular schwannoma presents unique challenges to the surgeon, given that the primary objectives are achieving complete resection while preserving both facial nerve and hearing function. Consequently, a comprehensive preoperative and perioperative assessment of the tumor is essential to determine its extent, particularly in cases involving dumbbell-shaped lesions. This case report describes our experience in managing a patient with a dumbbell-shaped vestibular schwannoma, where we achieved near-total resection while successfully preserving the patient’s facial nerve and hearing function. The early postoperative evaluation revealed no morbidity, and the patient experienced a significant improvement in their symptoms.
Light quality as a driver in adapting photosynthetic acclimation to niche partitioning
Authors: Kim Eunchul 
Published: November 2023

This article comments on:Sands E, Davies S, Puxty RJ, Verge V, Bouget F-Y, Scanlan DJ, Carre IA. 2023. Genetic and physiological responses to light quality in a deep ocean ecotype of Ostreococcus, an ecologically important photosynthetic picoeukaryote. Journal of Experimental Botany 74, 6773–6789.
Physiology, gene expression, and epiphenotype of two Dianthus broteri polyploid cytotypes under temperature stress
Authors: López-Jurado Javier , Picazo-Aragonés Jesús , Alonso Conchita , Balao Francisco , Mateos-Naranjo Enrique 
Published: November 2023

Abstract
Increasing evidence supports a major role for abiotic stress response in the success of plant polyploids, which usually thrive in harsh environments. However, understanding the ecophysiology of polyploids is challenging due to interactions between genome doubling and natural selection. Here, we investigated physiological responses, gene expression, and the epiphenotype of two related Dianthus broteri cytotypes—with different genome duplications (4× and 12×) and evolutionary trajectories—to short extreme temperature events (42/28 °C and 9/5 °C). The 12× cytotype showed higher expression of stress-responsive genes (SWEET1, PP2C16, AI5L3, and ATHB7) and enhanced gas exchange compared with 4×. Under heat stress, both ploidies had greatly impaired physiological performance and altered gene expression, with reduced cytosine methylation. However, the 12× cytotype exhibited remarkable physiological tolerance (maintaining gas exchange and water status via greater photochemical integrity and probably enhanced water storage) while down-regulating PP2C16 expression. Conversely, 4× D. broteri was susceptible to thermal stress despite prioritizing water conservation, showing signs of non-stomatal photosynthetic limitations and irreversible photochemical damage. This cytotype also presented gene-specific expression patterns under heat, up-regulating ATHB7. These findings provide insights into divergent stress response strategies and physiological resistance resulting from polyploidy, highlighting its widespread influence on plant function.
Three-dimensional fruit growth analysis clarifies developmental mechanisms underlying complex shape diversity in persimmon fruit
Authors: Kusumi Akane , Nishiyama Soichiro , Tao Ryutaro 
Published: November 2023

Abstract
The determination of fruit size and shape are of considerable interest in horticulture and developmental biology. Fruit typically exhibits three-dimensional structures characterized by geometric features that are dependent on the genotype. Although minor developmental variations have been recognized, few studies have fully visualized and measured these variations throughout fruit growth. Here, a high-resolution 3D scanner was used to investigate the fruit development of 51 persimmon (Diospyros kaki) cultivars with various complex shapes. We obtained 2380 3D models that fully represented fruit appearance, and enabled precise and automated measurements of shape features throughout fruit development, including horizontal and vertical grooves, length-to-width ratio, and roundness. The 3D fruit model analysis identified key stages that determined the shape attributes at maturity. Typically, genetic diversity was found in vertical groove development, and these grooves could be filled by tissue expansion in the carpel fusion zone during fruit development. In addition, transcriptome analysis of fruit tissues from groove and non-groove tissues revealed gene co-expression networks that were highly associated with groove depth variation. The presence of YABBY homologs was most closely associated with groove depth and indicated the possibility that this pathway is a key molecular contributor to vertical groove depth variation. Overall, our results revealed deterministic patterns of complex shape traits in persimmon fruit and showed that different growth patterns among tissues are the main factor contributing to the shape of both vertical and horizontal grooves.
Winds versus jets: a comparison between black hole feedback modes in simulations of idealized galaxy groups and clusters
Authors: Huško Filip , Lacey Cedric G , Schaye Joop , Nobels Folkert S J , Schaller Matthieu 
Published: November 2023

ABSTRACT
Using the SWIFT simulation code, we compare the effects of different forms of active galactic nuclei (AGNs) feedback in idealized galaxy groups and clusters. We first present a physically motivated model of black hole (BH) spin evolution and a numerical implementation of thermal isotropic feedback (representing the effects of energy-driven winds) and collimated kinetic jets that they launch at different accretion rates. We find that kinetic jet feedback is more efficient at quenching star formation in the brightest cluster galaxies (BCGs) than thermal isotropic feedback, while simultaneously yielding cooler cores in the intracluster medium (ICM). A hybrid model with both types of AGN feedback yields moderate star formation rates, while having the coolest cores. We then consider a simplified implementation of AGN feedback by fixing the feedback efficiencies and the jet direction, finding that the same general conclusions hold. We vary the feedback energetics (the kick velocity and the heating temperature), the fixed efficiencies and the type of energy (kinetic versus thermal) in both the isotropic and the jet case. The isotropic case is largely insensitive to these variations. On the other hand, jet feedback must be kinetic in order to be efficient at quenching. We also find that it is much more sensitive to the choice of energy per feedback event (the jet velocity), as well as the efficiency. The former indicates that jet velocities need to be carefully chosen in cosmological simulations, while the latter motivates the use of BH spin evolution models.