bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of the Value of Color Doppler Ultrasound in Patients With a Clinical Suspicion of Giant Cell Arteritis
Authors: Kaandorp Branko I. , Raterman Hennie G. , Stam Frank , Gamala Mihaela , Meijer‐Jorna Lorine B. , Kalb Fraukje B. , Wallis Jos W. 
Published: November 2023

ObjectiveIt is urgent to diagnose giant cell arteritis (GCA) as quickly as possible to prevent irreversible blindness. The traditional gold standard for diagnosing GCA is temporal artery biopsy (TAB). However, TAB lacks diagnostic performance and carries out risks of surgical intervention. The noninvasive color Doppler ultrasound (CDU) seems to be a promising alternative. This study is designed to assess the diagnostic value of CDU in daily clinical practice.MethodsIn this prospective cohort study, patients with a clinical suspicion of active GCA were included and underwent a CDU of the temporal arteries. If deemed necessary by the referrer, a TAB and/or 18F‐fluorodeoxyglucose positron emission tomography with computed tomography was performed. The retrospective clinical diagnosis was determined 1 year after inclusion by two physicians experienced in the field of vasculitis.Results242 patients were included and GCA was diagnosed in 73 (30%) patients by the defined retrospective clinical diagnosis. Compared with the retrospective diagnosis, CDU has a sensitivity of 60% (48–72), specificity of 94% (89–97), positive predictive value (PPV) of 81% (70–89), negative predictive value (NPV) of 85% (80–88), and an accuracy of 84% (78–88). A total of 84 (35%) patients underwent TAB. TAB has a sensitivity of 66% (51–79), specificity of 100% (90–100), PPV of 100% (100), NPV of 67% (58–75), and an accuracy of 80% (70–88).ConclusionThis study shows comparable diagnostic performance for CDU and TAB and even better CDU results with a bilateral halo present. Considering the advantages of the noninvasive CDU, it is the diagnostic tool of choice.
Rheumatology Patients’ Experiences of a Mandatory Nationwide Transition to an Adalimumab Biosimilar
Authors: Gasteiger Chiara , Lobo Maria , Stanley Robin , Wong Lun Shen , Murdoch Rachel , Dalbeth Nicola 
Published: November 2023

ObjectiveTransitions to biosimilars are common to reduce the cost burden of biologics. While brand changes can be daunting for patients, few studies have explored patients’ experiences with the transitioning process. This study examined rheumatology patients’ experiences with a mandatory nationwide brand change to an adalimumab biosimilar.MethodsPeople with rheumatic diseases involved in the adalimumab transition in Aotearoa New Zealand completed a nationwide online survey. Participants (n = 117, 48% with rheumatoid arthritis) reported their satisfaction with the biosimilar, logistics and supply, information and communication, and availability of support. They also reported what did and did not go well during the transition and provided recommendations for future transitions.ResultsThe mean [SD] satisfaction score with the transition was 6.2 [3.2] on a 0‐10 scale, with 10 indicating high satisfaction. Participants were the least satisfied with the support and information from patient support organizations, and training for the device during the transition. Participants were most satisfied with the biosimilar supply, support from pharmacists, and how early they were informed before the transition occurred. After the transition, participants were less satisfied with the device quality, patient support program, biosimilar safety and efficacy, and the provision of alcohol wipes and sharps bins (p < 0.05 for all). Satisfaction with training for the biosimilar device (B = .25, p = .036) predicted overall satisfaction. Participants appreciated less injection pain and the ease of the biosimilar device. The lack of alcohol wipes and loss of the bio‐originator support program were viewed negatively.ConclusionFuture biosimilar transitions should ensure the availability of alcohol wipes, sharps bins, and a comparable patient support program. Patient support organizations could be involved in providing information to patients about the change.
Decoding the Heterogeneity and Specialized Function of Translation Machinery Through Ribosome Profiling in Yeast Mutants of Initiation Factors
Authors: Wang Jia , Zhang Geyu , Qian Wenfeng , Li Ke 
Published: November 2023

AbstractThe nuanced heterogeneity and specialized functions of translation machinery are increasingly recognized as crucial for precise translational regulation. Here, high‐throughput ribosomal profiling (ribo‐seq) is used to analyze the specialized roles of eukaryotic initiation factors (eIFs) in the budding yeast. By examining changes in ribosomal distribution across the genome resulting from knockouts of eIF4A, eIF4B, eIF4G1, CAF20, or EAP1, or knockdowns of eIF1, eIF1A, eIF4E, or PAB1, two distinct initiation‐factor groups, the “looping” and “scanning” groups are discerned, based on similarities in the ribosomal landscapes their perturbation induced. The study delves into the cis‐regulatory sequence features of genes influenced predominantly by each group, revealing that genes more dependent on the looping‐group factors generally have shorter transcripts and poly(A) tails. In contrast, genes more dependent on the scanning‐group factors often possess upstream open reading frames and exhibit a higher GC content in their 5′ untranslated regions. From the ribosomal RNA fragments identified in the ribo‐seq data, ribosomal heterogeneity associated with perturbation of specific initiation factors is further identified, suggesting their potential roles in regulating ribosomal components. Collectively, the study illuminates the complexity of translational regulation driven by heterogeneity and specialized functions of translation machinery, presenting potential approaches for targeted gene translation manipulation.
Anisotropic and High‐Mobility Electronic Transport in a Quasi 2D Antiferromagnet NdSb2
Authors: Singha Ratnadwip , Yuan Fang , Lee Scott B. , Villalpando Graciela V. , Cheng Guangming , Singh Birender , Sarker Suchismita , Yao Nan , Burch Kenneth S. , Schoop Leslie M. 
Published: November 2023

AbstractAdvancements in low‐dimensional functional device technology heavily rely on the discovery of suitable materials which have interesting physical properties as well as can be exfoliated down to the 2D limit. Exfoliable high‐mobility magnets are one such class of materials that, not due to lack of effort, has been limited to only a handful of options. So far, most of the attention has been focused on the van der Waals (vdW) systems. However, even within the non‐vdW, layered materials, it is possible to find all these desirable features. Using chemical reasoning, it is found that NdSb2 is an ideal example. Even with a relatively small interlayer distance, this material can be exfoliated down to few layers. NdSb2 has an antiferromagnetic ground state with a quasi 2D spin arrangement. The bulk crystals show a very large, non‐saturating magnetoresistance along with highly anisotropic electronic transport properties. It is confirmed that this anisotropy originates from the 2D Fermi pockets which also imply a rather quasi 2D confinement of the charge carrier density. Both electron and hole‐type carriers show very high mobilities. The possible non‐collinear spin arrangement also results in an anomalous Hall effect.
Direct Photolithography Patterning of Quantum Dot‐Polymer
Authors: Guo Weishu , Chen Jun , Ma Teng , Chen Ziyi , Li Mulin , Zeng Haibo , Lu Jian 
Published: November 2023

AbstractFor the new display technology based on quantum dots (QDs), achieving high‐precision red, green, and blue pixel arrays has always been a research focus in the pursuit of high‐quality and vivid image displays. However, problems such as material stability and process environment make it difficult to guarantee the quality of high‐precision patterns. The new optical patterning technology represented by direct photolithography is considered a highly promising method for achieving ultrafine patterns at the submicron level. This process prepares patterned quantum dot‐polymer films through light‐induced chemical changes. This paper reviews the progress of direct photolithography research focused on QD‐polymer materials and presents recent advances in such processes for monochromatic/multicolor light patterning. The article classifies QD‐polymers into three categories by combining QDs with polymers in different ways, including polymer‐coated QDs, polymers as QD ligands, and polymers as photocrosslinkers for QDs. Their synthesis schemes, functional features, and challenges are also presented. In addition, a scheme to remove the photomask during direct lithography using lasers and light field modulation is also proposed. It aims to provide readers and researchers with some generalized research information and improvement ideas. This can further advance the development of direct photolithography for QD‐polymers.
Triboelectric Nanogenerator Enabled Sweat Extraction and Power Activation for Sweat Monitoring
Authors: Xu Guoqiang , Huang Xingcan , Shi Rui , Yang Yawen , Wu Pengchen , Zhou Jingkun , He Xinxin , Li Jialin , Zen Yuyang , Jiao Yanli , Zhang Binbin , Li Jiyu , Zhao Guangyao , Liu Yiming , Huang Ya , Wu Mengge , Zhang Qiang , Yang Zhihui , Yu Xinge 
Published: November 2023

AbstractWearable sweat sensors can detect and monitor various substances in sweat, providing valuable information for healthcare monitoring and clinical diagnostics. Recent advances in flexible electronic technologies have enabled the development of wearable sweat sensors that can measure sweat rate and biochemical substances in real time, although several challenges remain, such as power management and sweat extraction issues. Here, a passive sweat extraction strategy as well as a self‐powered monitoring system (SEMS) is reported to be designed for sedentary individuals, i.e., elders. The SEMS system comprises a wearable triboelectric nanogenerator (TENG) for sweat extraction, a sweat‐activated battery (SAB) as the integrated power source, carbachol‐loaded iontophoresis electrodes for sweat extraction, microfluidics with biosensors for detecting physiological information in sweat, and near field communication (NFC)‐based wireless microelectronics for data communication, processing, and collection. By tapping the TENG, sedentary people can passively extract sweat based on the iontophoresis process, allowing the sensors to detect biological information in sweat. The good flexibility of the SEMS device enables real‐time and non‐invasive detection of sweat analytes in a wearable format. This system offers a new strategy of sweat collection and analysis for the elderly group, and therefore can help to understand human physiology and personalize health monitoring deeply.
Mechanism of Fast Storage of Li/Na in Complex Sb‐Based Hybrid System
Authors: Xiang Yinger , Hu Xinyu , Zhong Xue , Deng Wentao , Zou Guoqiang , Hou Hongshuai , Ji Xiaobo 
Published: November 2023

AbstractAntimony（Sb） has high theoretical specific capacity and moderate reaction potential, but poor cycling stability and rate performance caused by large volume expansion and sluggish reaction kinetics limit its development in alkali‐ion batteries. The construction of carbon/Sb composites can solve this problem, but the traditional single carbon composite and poor Sb/carbon interface have limited promotion. Here, under the guidance of theoretical calculations, a strategy of hierarchical double carbon composite is proposed to enhance the performance of Sb anode, and systematically reveal the lithium/sodium ions (Li+/Na+) storage mechanism of Sb in complex composite system. Sb nanoparticles (Sb NPs) are encapsulated in carbon sphere matrix with strong interfacial chemical bond to form the first level composite material, and then the highly conductive and mechanically strong graphene is used as a three‐dimensional skeleton network to connect the first level composite to form the second level composite material. The hierarchical double carbon/Sb composite exhibits excellent rate (228 mAh g−1 @ 20 A g−1) and long cycling performance (373.7 mAh g−1 @ 2 A g−1 after 2200 cycles, capacity retention of 93.1%). This work may expand structural design and interface regulation of Sb/C composites and providing theoretical guidance for metal anodes development.
Living Cell‐Derived Intelligent Nanobots for Precision Oncotherapy
Authors: Zhou Liqiang , Li Kun , Liu Yingying , Zhang Rongjie , Yao Yangcheng , Chen Qiqing , Xie Dong , Zhang Xuanjun 
Published: November 2023

AbstractThe progress of precision oncology medicine is always limited by the tumor off‐targeting, the drug side effects, and the treatment inefficiency due to the complex and ever‐changing tumor microenvironment. Living cells, such as blood cells and immune cells, exhibit natural tumor tropism, controllable physicochemical modification, and excellent biocompatibility, which provide an advantageous pathway for innovative and efficient tumor suppression. Armed with nanoengineering techniques, artificial living cells harness their inherent biological properties to precisely identify and eradicate tumors, demonstrating broad biological application prospects and great transformational potential in personalized cancer therapy. Here, the recent advances of living cell‐based bionanobots including platelets, red blood cells, neutrophil, macrophage, and CAR‐T cells for cancer precision therapy and immune regulation are summarized, and the efficient anti‐tumor strategies for engineering living cell nanorobots to overcome complex biological barriers and immune suppression are also outlined (e.g., immunotherapy, sonodynamic therapy, chemo/radiotherapy, and phototherapy). In addition, the study discusses the advantages, limitations, and current challenges of artificial living cell‐based drug delivery systems, and provide perspectives on the future development of living cell‐mediated precision tumor nanomedicine.
Al‐doped ZnO‐Coated LiNi1/3Mn1/3Co1/3O2 Powder Electrodes: The Effect of a Coating Layer on The Structural and Chemical Stability of The Electrode / Electrolyte Interface
Authors: Makvandi Ardavan , Wolff Michael , Lobe Sandra , Heidrich Bastian , Peterlechner Martin , Gammer Christoph , Uhlenbruck Sven , Winter Martin , Wilde Gerhard 
Published: November 2023

AbstractLiNi1/3Mn1/3Co1/3O2 (NMC‐111) is one of the most popular cathode materials in Li‐ion batteries. However, chemical and structural instabilities of the cathode/electrolyte interface at high charge cut‐off voltages cause capacity fading. Surface modifications using metal oxides are promising candidates to suppress capacity fading. Here a systematic study on the degradation mechanism of an uncoated NMC‐111 powder electrode is presented. Moreover, the effect of an Al‐doped ZnO (Al:ZnO) coating layer on the structural and chemical stabilities of NMC‐111 electrode cycled at high charge cut‐off voltages is analyzed using X‐ray photoelectron spectroscopy, scanning electron microscopy and analytical transmission electron microscopy as well as electrochemical testing. The coating is applied to commercial NMC‐111 powder using a microwave‐assisted sol‐gel synthesis method. In the case of uncoated NMC‐111 electrodes, pitting corrosion due to hydrofluoric acid attacking the electrode surface, cation mixing, and an irreversible phase transformation from a trigonal layered to a rock‐salt phase occurs, causing capacity fading. While, in the case of Al:ZnO – coated NMC‐111 electrodes, pitting corrosion, cation mixing, and the irreversible phase transformation are mitigated. Therefore, the capacity retention and rate capability are improved as the coating layer protects the electrode surface from the direct electrolyte exposure.
RETRACTED: Organic Cocrystal Design to Promote Absorption and Triplet Excitons Formation for Sensitive Scintillator
Authors: Lei Yutian , Peng Guoqiang , Xu Youkui , Wang Haoxu , Li ZhenHua , Jin Zhiwen 
Published: November 2023

AbstractOrganic materials show good mechanical flexibility, easy processing, and large‐area manufacturing, while weak X‐ray absorption and low sensitivity for X‐ray scintillator media. As seen originally, this is a synergistic result of the lack of heavy elements in the molecule that can effectively truncate X‐rays and the massive dissipation of triplet excitons produced by molecular ionization. Herein, cocrystal with phosphorescence enhancement is found to be brilliant in addressing the shortcomings of organic scintillators. The results show that heavy atoms can be easily introduce into the donor unit of organic cocrystal to satisfy the X‐ray absorption and effectively activate the triplet excitons via promoting intersystem crossing (ISC). Moreover, the rational structural design of the acceptor molecule can achieve coupling with the donor for inhibiting the non‐radiative loss of the triplet exciton. Finally, the preferred PNPA (4,4′‐Dibromobiphenyl and N‐phenylnaphthalen‐2‐amine) cocrystals achieve record X‐ray‐induce exciton utilization and emit bright phosphorescent light. Meanwhile, the related device shows durable radiation stability, spatial resolution (>11 lp mm−1), low detection limit (<0.6 µGyair s−1), and effective dynamic imaging application. Hence, it is believed the organic cocrystal‐designed principle can provide guidance to develop advanced sensitive X‐ray scintillators in the future.
Sub‐Nanoconfined Aggregation‐Induced Emission Molecules via Stacked Layers of Microtubular Covalent Organic Frameworks for Enhanced Fluorescence
Authors: Wang Qiyan , Han Dandan , Zhang Zhen , Rezayan Armin , Chen Sheng , Zhang Qidong , Dong Lin , Sun Junlu , Wei Ronghan , Wu Dan 
Published: November 2023

AbstractFunctionalizing aggregation‐induced emission molecules (AIEs) by confining them in porous materials is attracted extensive attention. Here stacked layers of hollow microtubular covalent organic frameworks (HT‐COFs) are introduced as sub‐nanoconfined sites (0.37 nm) to confine AIEs. The spacious hollow channels allow unimpeded entry for AIEs, while the interlayers perpendicular to the channels partially incarcerate the AIEs within the COFs layers. This effectively restricts the intramolecular rotation of AIEs and facilitates its radiative processes. Through exchanging of various AIEs, the versatility of the COFs interlayer as a restriction site is demonstrated. Furthermore, the sub‐nanoconfined fluorescence in AIEs@HT‐COFs displays reversible temperature dependence. Based on this, a temperature‐tunable fluorescent Micro‐QR code device is fabricated, wherein the encoded information disappears at a high‐temperature and reemerges at a low‐temperature. This work offers novel insights into confined fluorescence within functional materials and the fabrication of AIEs‐COF multiplex frameworks.
Epitaxy‐Directed Self‐Assembly of Copolymers and Polymer Blends
Authors: Hou Chunyue , Wang Junjie , Wang Peng , Cui Jiahui , Wang Shaojuan , Xin Rui , Li Huihui , Sun Xiaoli , Ren Zhongjie , Yan Shouke 
Published: November 2023

AbstractDirected self‐assembly of materials into patterned structures is of great importance since the performance of them depends remarkably on their multiscale hierarchical structures. Therefore, purposeful structural regulation at different length scales through crystallization engineering provides an opportunity to modify the properties of polymeric materials. Here, an epitaxy‐directed self‐assembly strategy for regulating the pattern structures including phase structure as well as crystal modification and orientation of each component for both copolymers and polymer blends is reported. Owing to the specific crystallography registration between the depositing crystalline polymers and the underlying crystalline substrate, not only order phase structure with controlled size at nanometer scale but also the crystal structure and chain orientation of each component within the separated phases for both copolymers and polymer blend systems can be precisely regulated.
Perovskite Lanthanum‐Doped Barium Stannate: A Refractory Near‐Zero‐Index Material for High‐Temperature Energy Harvesting Systems
Authors: Kim Hyebi , Kim Geunpil , Jeon Young‐Uk , Lee Wonjun , Lee Byeong‐Hyeon , Kim In Soo , Lee Kwanil , Kim Soo Jin , Kim Jongbum 
Published: November 2023

AbstractThe recent interests in bridging intriguing optical phenomena and thermal energy management has led to the demonstration of controlling thermal radiation with epsilon‐near‐zero (ENZ) and the related near‐zero‐index (NZI) optical media. In particular, the manipulation of thermal emission using phononic ENZ and NZI materials has shown promise in mid‐infrared radiative cooling systems operating under low‐temperature environments (below 100 °C). However, the absence of NZI materials capable of withstanding high temperatures has limited the spectral extension of these advanced technologies to the near‐infrared (NIR) regime. Herein, a perovskite conducting oxide, lanthanum‐doped barium stannate (La:BaSnO3 [LBSO]), as a refractory NZI material well suited for engineering NIR thermal emission is proposed. This work focuses on the experimental demonstration of superior high‐temperature stability (of at least 1000 °C) of LBSO films in air and its durability under intense UV‐pulsed laser irradiation below peak power of 9 MW cm−2. Based on the low optical‐loss in LBSO, a selective narrow‐band thermal emission utilizing a metal‐insulator‐metal (MIM) Fabry–Pérot nanocavity consisting of LBSO films as metallic component is demonstrated. This study shows that LBSO is an ideal candidate as a refractory NZI component for thermal energy conversion operating at high temperatures in air and under strong light irradiations.
Synthetic Collagen Hydrogels through Symmetric Self‐Assembly of Small Peptides
Authors: Tanrikulu I. Caglar , Dang Lianna , Nelavelli Lekha , Ellison Aubrey J. , Olsen Bradley D. , Jin Song , Raines Ronald T. 
Published: November 2023

AbstractAnimal‐sourced hydrogels, such as collagen, are widely used as extracellular‐matrix (ECM) mimics in tissue engineering but are plagued with problems of reproducibility, immunogenicity, and contamination. Synthetic, chemically defined hydrogels can avoid such issues. Despite the abundance of collagen in the ECM, synthetic collagen hydrogels are extremely rare due to design challenges brought on by the triple‐helical structure of collagen. Sticky‐ended symmetric self‐assembly (SESSA) overcomes these challenges by maximizing interactions between the strands of the triple helix, allowing the assembly of collagen‐mimetic peptides (CMPs) into robust synthetic collagen nanofibers. This optimization, however, also minimizes interfiber contacts. In this work, symmetric association states for the SESSA of short CMPs to probe their increased propensity for interfiber association are modelled. It is found that 33‐residue CMPs not only self‐assemble through sticky ends, but also form hydrogels. These self‐assemblies behave with remarkable consistency across multiple scales and present a clear link between their triple‐helical architecture and the properties of their hydrogels. The results show that SESSA is an effective and robust design methodology that enables the rational design of synthetic collagen hydrogels.