bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of physical activity and stress reactivity with depression in elderly hypertensive population: A cross-sectional study from Eastern India
Authors: Banerjee Arijita , Kumar Sumit , Dasgupta Shirin 
Published: November 2023

Objective:
Depressive disorder poses an increased risk for sudden cardiac death in elderly population with existing comorbidities. Also, few international studies suggest the association of decreased stress reactivity with symptoms of depression in old age. Our cross-sectional study has attempted to explore the relationship of daily exercise and stress reactivity with depression in elderly individuals with hypertension.

Methods:
Depression was assessed using Hamilton depression rating scale or HAM-D. The physical activity was assessed using the global physical activity questionnaire (GPAQ), developed by WHO. Stress reactivity is calculated from various cardiovascular parameters. The relationship of physical activity and stress reactivity scores on depression was explored using regression analysis.

Results:
The prevalence rate of depressive symptoms in elderly hypertension population was around 40.2%. Significantly lower reactivity scores (P = 0.032) to deep breathing were evident in elderly hypertension population. After proper adjustment of the confounding factors, regression analysis depicted that decreased physical activity (Odds ratio = 4.48; 95% Confidence interval = 2.32–7.69) resulted in heavy risk of developing depressive symptoms besides old age and low educational status.

Conclusion:
Our ﬁndings suggest that low physical activity leads to the development of depressive symptoms and decreased stress reactivity among elderly hypertensive patients.
Predictors of maternal and fetal outcome in severely anemic pregnant mothers: A sequential mixed methods study
Authors: Saraswathy V. , Subashini M. , Jayavani R. L. , Vaithiyanathan Usha , Mohan Reenaa , Sindhuri R. 
Published: November 2023

Introduction:
Severe anemia in pregnancy increases maternal and neonatal morbidity and mortality in the antenatal period.

Objective:
To find out the maternal and fetal outcomes in severely anemic pregnant women and explore the reason for the persistence of severe anemia in pregnant women.

Materials and Methods:
Sequential explanatory mixed method study (Quan-Qual) was conducted in the Government Women and Children Hospital for a period of 1 and half years. Most of the people were from rural backgrounds and belonging to low socioeconomic status have been registered. Quantitative data were collected from 125 severe anemic cases; a consecutive sampling technique was applied. In-depth interviews were conducted among purposively selected severe anemic patients (n = 15) who were vocal and willing to explore the reason for the persistence of anemia. The interviews were conducted till the point of saturation. Ethical principles were adhered throughout the study. Quantitative data were anlyzed using SPSS software. Manual content analysis was done for qualitative data.

Results:
Among 125 severe anemic patients, 12.8% patients had preterm labour, about 23.2% had inadequate lactation, and 13.6% had a puerperal febrile illness. It was found 41.6% of neonates had respiratory distress and 33.6% had the refusal of feeds. When compared to vaginal delivery, women undergoing cesarean section have 3.2 times (95% confidence interval 1.39-7.32) higher odds of developing maternal complications. Nagelkerke's R2 value for the model was 11.1%. Five broad categories namely Family centric nature, Lack of awareness, Pill burden, Food Fads, and Myths related to iron intake emerged from the study.

Conclusion:
Complications can occur in mothers and neonates if anemia is not corrected in early trimester.
Prevalence and determinants of adverse events following ChAdOx1 nCoV-19 vaccination (COVISHIELD) – A retrospective cohort study among healthcare workers in central Karnataka, India
Authors: Davalagi Shubha B. , Nayak Vaman P. , Ghose Anisha , Marakatti Siddarth S. , Kasturi Eshwar S. , Maganahalli Anurupa S. 
Published: November 2023

Background:India has launched COVID vaccination program on January 16, 2021 and precautionary dose (third dose) on January 10, 2022. Our study evaluated adverse events following immunization (AEFI) among healthcare workers (HCWs) following first, second, and precautionary dose of ChAdOx1 nCoV-19 (COVISHIELD) vaccine. We also evaluated the association of AEFI with the study participants' characteristics.Objectives:(1) To assess the adverse events among HCWs following first, second, and precautionary dose of COVISHIELD vaccine. (2) To determine the factors associated with adverse events of COVISHIELD vaccine.Materials and Methods:A retrospective cohort study was conducted among HCWs of a tertiary care teaching hospital in central Karnataka from January 2021 to June 2022. A semi-structured, pretested questionnaire was used to interview the HCW of tertiary care teaching hospital regarding adverse events following first, second, and precautionary dose of COVISHIELD vaccine; data collected was entered in MS Excel 2019 and analyzed using SPSS v24.0.Results:Among 454 participants majority of them were females (231, 50.88%) and in the age group 18-27 years (151, 33.25%), and the majority were nursing staff (147, 32.37%). Adverse events were reported among 204 (44.93%) following the first dose, 149 (32.81%) after the second dose, and 230 (50.66%) participants following the precautionary dose. Generalized weakness and fever were the common adverse effects reported by participants.Conclusion:Majority of the study population did not report any adverse events following vaccination. Among the study participants who reported adverse events, most events were reported on the same day. Symptoms were mild in severity and short-lived.
Bevacizumab combined with platinum-based chemotherapy in primary or relapsed ovarian cancer patients: Meta-analysis and literature to review
Authors: Tauseef Abubakar , Zafar Maryam , Abodunrin Faith , Siddiqui Sameed A. H. , Millner Paul , Khan Saber M. , Teplitsky Ella , Masih Durva , Mirza Muazzam , Mirza Mohsin 
Published: November 2023

Introduction:
Earlier, patients with advanced ovarian cancer were treated with a combination of cytoreductive surgery and platinum-based chemotherapy, which had significant outcomes in the past until an increase in relapse and resistance to treatment, which led to the use or development of bevacizumab (a vascular endothelial growth factor inhibitor) in the treatment of primary or relapsed ovarian cancer.

Method and Methodology:
This study includes five-phase three randomized controlled clinical trials designed to study the impact of bevacizumab in combination with platinum-based chemotherapy compared with platinum-based chemotherapy alone.

Results:
This study demonstrated significant improvement in the progression-free span but no improvement in overall survival in the treatment group when compared with the control group. Also, adverse effects reported with combination therapy were tolerable and easily manageable by decreasing the infusion rate or by decreasing the frequency of infusion.
Patients' perceptions of telehealth video visits experience in primary healthcare setting, Saudi Arabia
Authors: Alotaibi Hanan F. , Ghazi Sultan S. , Asraf Nisreen O. , Al Asmari Zahra S. 
Published: November 2023

Background:
The widespread utilization of telehealth recently in Saudi Arabia is unprepared and may have a remarkable adverse effect on healthcare delivery. The study aimed to investigate attitude, satisfaction, and barriers of telehealth application among patients.

Materials and Methods:
A cross-sectional study was conducted at primary healthcare centers during the period of December 2021–January 2022. All Saudi patients (≥18 years) who were treated through telehealth programs in specialized polyclinic were eligible for study inclusion. A self-administered questionnaire was utilized and consists of four main parts: personal information, history of using telehealth, assessment of satisfaction with telehealth program, and attitude toward telemedicine.

Results:
A total of 641 participants were included. Females represented 57.3% of them. A majority (82.7%) of patients were satisfied with telemedicine services. Multivariate logistic regression analysis revealed that Bachelor/postgraduates were more likely to be satisfied with telemedicine services (P < 0.001), whereas patients reported no appointment slot in the clinic were less likely to be satisfied with telemedicine services (P = 0.042). A majority of patients (84.1%) expressed positive attitude toward telemedicine services. Multivariate logistic regression analysis revealed that older patients (P = 0.002) and widowed (P = 0.001) were less likely to have positive attitude toward utilization of telemedicine services, whereas Bachelor/postgraduates (P = 0.038) and patients with more than this time were more likely to have positive attitude toward telemedicine services (P = 0.001).

Conclusion:
Patients were overall satisfied and expressed positive attitude concerning the service of telemedicine consultation. However, more in-depth investigation is recommended to better understand the predictors of satisfaction with telemedicine and barriers for its proper application.
View of mucormycosis during the era of COVID-19 infection: A cross-sectional study
Authors: Zakaria Ossama M. , Alkuwaity Dana W. 
Published: November 2023

Background:
During the coronavirus (COVID-19) global pandemic, the diagnosis of mucormycosis co-infection has become challenging as it is sometimes misdiagnosed or even undiagnosed. Many factors contribute to acquiring such infections. These factors vary but their main reason for getting such infections is being immunocompromised. Thus, it results in weak host immunity to fight and prevent such co-infection.

Objectives:
This study aims to assess the knowledge perception among the general population in Saudi Arabia regarding black fungus and its relationship with the global pandemic COVID-19.

Materials and Methods:
A prospective, qualitative, questionnaire-based cross-sectional study took place. The obtained data were statistically analyzed using SPSS version 21.

Results:
The study included 1138 participants, 31.5% from southern region, 27.8% from Eastern region, 22.2% from north region, 12.2% from Western region, and 6.3% from Central region. The participant's mean age was 27.1 ± 11.9 years old. A good knowledge level was detected among 35% of female respondents compared to 28.9% of males with reported statistical significance (P =0.036). All other factors including age, education, and work were insignificantly associated with public knowledge level.

Conclusions:
A considerable percentage of the current study population had poor knowledge level of perception and awareness regarding mucormycosis in relation to COVID-19.
Clinicoepidemiologic profile of leprosy in geriatric population in post-elimination era: A retrospective, hospital-based, cross-sectional study from Eastern India
Authors: Pradhan Swetalina , Shahid Rashid , Singh Suvesh 
Published: November 2023

Background and Aim:
Geriatric populations are susceptible to leprosy infection with masked clinical signs due to lower immunity in them. Our aim was to analyze the clinicoepidemiologic profile of patients with geriatric leprosy and find out the reasons for delayed diagnosis and treatment.

Materials and Methods:
A retrospective, record-based study was conducted in a tertiary care center from May 2019 to May 2022. The clinicodemographic data of biopsy-confirmed leprosy cases aged ≥60 years were obtained from the leprosy clinic record. Various reasons for the delay in treatment were also recorded. Simple statistics was used for analysis.

Results:
Out of 605 leprosy cases, 50 (7.4%) cases belonged to the geriatric population. Males outnumbered females (M/F = 37/13). The mean age of the patients was 66.28 + 6.5 years. Maximum patients belonged to 60–69 years of age. The mean duration of illness was 35.22 months (range 1–240 months). Most of the patients were illiterate (33.6%), and 56% were farmers by occupation. The ulnar nerve was the most common nerve to be thickened in 90% (45/50) cases, followed by the common peroneal nerve in 54% (27/50) cases, radical cutaneous nerve in 52% (26/50) cases, and posterior tibial nerve in 24% (12/50) cases. Borderline tuberculoid was the most common type in 44% cases, followed by lepromatous leprosy in 22%, borderline lepromatous leprosy in 18% (9/50), and pure neuritic leprosy in 14%. Type 1 and type 2 lepra reactions were found in 18% and 14% cases, respectively. Also, 38% had grade 2 disability. Common reasons for the delay in treatment were financial constraints, lack of family support, and personal superstitious beliefs. The study was limited by its retrospective nature.

Conclusion:
Geriatric leprosy needs special attention as the elderly are more prone for deformities; also, because of low immunity, there is a high chance of developing multibacillary leprosy, and therefore, they are potential sources of infection to the community.
From designing minimum data set to developing kidney transplantation registry in Iran
Authors: Akhlaghi Ahmad , Langarizadeh Mostafa , Rahimzadeh Nahid , Rostami Zohreh 
Published: November 2023

Objective:
Currently, population growth and increasing life expectancy are becoming one of the biggest public health challenges in the world, which has increased the prevalence of chronic diseases such as end-stage renal disease and the need for kidney transplantation. The use of a variety of registries has the potential to determine the effectiveness of clinical care and costs and improve the quality of patient care. The aim of this study is to design minimum data set to develop a kidney transplantation registry in Iran to improve the quality of care for people with end-stage renal disease.

Methods:
The present research is descriptive-applied. The minimum data set was reviewed and evaluated in expert panel meetings. The various elements of the minimum data set were discussed, and specialists in urology, nephrology, health information management, and medical informatics presented their views.

Results:
The characteristics of the kidney transplantation registry in the form of eight axes of purpose, structure, data sources, minimum data set, classification systems, data processing and reporting, distribution and access to information, and data quality were extracted and finally these characteristics were approved by experts. The relevant tables were validated and were within the acceptable range from the point of view of experts.

Conclusion:
In developing a kidney transplantation registry in Iran, the necessary requirements and features for designing a web-based registry have been considered. The prototype of this registry in the country will help to collect higher quality data. It is hoped that by developing this registry, a step will be taken to better manage the information on people with end-stage renal disease, provide better services to these patients, and facilitate related research.
Study of menstrual cycle synchrony in female medical students sharing common accommodation
Authors: Siddiqui Nazeem I. , Chinchole Sangeeta , Khan Sarfaraz A. , Bose Sukhwant , Mishra Piyush K. 
Published: November 2023

Context:
Menstrual cycle synchronization is a phenomenon in which menstrual onset shifts progressively closer with time. It is an adoptive conditional phenomenon seen in the females who associate closely and share a common environment.

Aims:
To ascertain whether menstrual cycle synchrony exists in the roommates living in a closed space in a medical hostel.

Settings and Design:
This is a prospective observational study comprising 62 female medical students of a mean age of 22 years living in twin sharing accommodation with a history of regular menses (26–32 days).

Methods and Material:
These participants were followed on a monthly basis for 13 months. Menstrual cycle history was obtained using standardized Google forms. Menstrual cycle initial and final onset differences, expected cycle cut-off values, and absolute differences were calculated. The menstrual cycle synchrony score was obtained by subtracting the expected difference from the onset difference. Wilson's absolute difference method was used for determining menstrual synchrony between pairs.

Statistical Analysis Used:
The descriptive analysis was done using mean and standard deviation. One sample t-test was used to assess the synchrony between roommates. P value ≤0.05 was considered as statistically significant.

Results:
The initial onset difference of the menstrual cycle was 7.58 ± 4.25 days, whereas the final onset difference was 6.06 ± 3.92 days. The calculated synchrony score was -9.28 ± 5.05, which was statistically significant. Menstrual cycle synchrony was observed in 17 pairs (54.8%) and asynchrony in eight pairs (25.8%).

Conclusions:
Long-term association between roommates has potential to cause menstrual cycle synchrony. It has significant implications in reproductive medicine for reproductive scheduling and family planning.
Smoked tobacco dependence and its correlates among participants attending life skills training and counselling services programme across Karnataka (2017–2022)
Authors: Therat Sonia , Banandur Pradeep S. , Sukumar Gautham M. , Shenoy Anusha B. , Arvind Banavaram A. , Nagaraja Srividya Rudrapattana , Rai Veeksha , Medhi Upashana , Devyani Azad 
Published: November 2023

Introduction:
Indian National Mental Health Survey reports an alarming prevalence of 20.9% for tobacco dependence in India. Dependence on smoked tobacco can be prevented by thorough knowledge of the risk factors associated with it.

Objectives:
To estimate the prevalence and identify the factors associated with smoked tobacco dependence among participants attending the life skills training and counselling services programme (LSTCSP) across Karnataka from 2017 to 2022.

Materials and Methods:
Pretraining data of 3104 participants from training programmes between 2017 and 2022 were utilised. Univariate and multivariable logistic regression analysis was performed based on a conceptual framework with various hypothesised exposure variables and smoked tobacco dependence as outcome.

Results:
The overall prevalence of smoked tobacco dependence among LSTCSP participants who used smoked tobacco products was 59.4%. Ever use of smokeless tobacco products (Adjusted odds ratio (AOR) =2.05, 95% CI: 1.11–3.78) and screening positive for symptoms of generalised anxiety (AOR = 2.53, 95% CI: 1.32–4.84) significantly increased the odds of smoked tobacco dependence, whereas making decisions collectively in the family (AOR = 0.35, 95% CI: 0.18–0.66) and individuals with increased score for neurotic personality traits (AOR = 0.64, 95% CI: 0.44–0.93) were the factors associated with reduced odds of smoked tobacco dependence.

Conclusion:
The identified risk factors associated with smoked tobacco dependence are important to develop tobacco control programmes as well as in preventing its onset. With the risk factors for smoked tobacco dependence identified, the results of this study have implications for health promotion and prevention programmes as well as cessation programmes related to smoked tobacco dependence, within India and similar countries.
Study of HbA1c levels in non-diabetic individuals recovered from Covid-19
Authors: Gandikota Sainithesh , Sudha Kothapalle Sowmya , Naramalli Madhavi Latha 
Published: November 2023

Objectives:
To study the glycemic control by estimating HbA1c levels among previously non-diabetic individuals aged above 40 years, who recovered from coronavirus disease 2019 (Covid-19) infection.

Materials and Methods:
This is an analytical cross-sectional study of people affected with Covid-19 infection, who were home-isolated, hospitalized, and discharged. The simple random sampling technique was used for the study group. Tirupati City, Andhra Pradesh State, India. We assessed socio-demographic profiles, hba1c levels, RBS, and severity of infection. The obtained laboratory reports were analyzed by using means and proportions after entering data in MS Excel and converted to SPSS software new version.

Results:
The study participants comprised mostly middle age group males and females (mostly 40–60 years, with 60% of them being females). Most of the study subjects were healthy, and 58% of them have normal hba1c levels. 32% of them are in border line diabetic. The prevalence of diabetes post Covid-19 infection is 10%. The majority of participants have normal random blood sugar levels (around 92%), and very less individuals have abnormal random blood sugar levels (2% of the subjects). There is no significant association between hypertension and raised blood sugar levels post Covid-19 infection.

Conclusions:
Based on the study, Covid-19 infection has an impact on blood sugar levels and altered glycemic control, switching a few individuals into diabetic and a significant number of individuals into the pre-diabetic state, who are non-diabetic individuals before Covid-19 infection.
Effect of preterm birth on blood pressure in later life: A systematic review and meta-analysis
Authors: Alsubai Abdulla K. , Ahmad Mushtaq , Chang Rabia , Asghar Mustafa A. , Siddiqui Amna , Khan Hamza N. , Ashraf Muhammad H. , Javaid Muhammad D. , Kalwar Asifa , Asad Mahnoor , Memon Kainat , Khan Laibah A. , Noorani Amber , Siddiqi Ahmed K. 
Published: November 2023

Introduction:Preterm birth is linked to various complications in both infancy and adulthood. We assessed the association between preterm birth and hypertension in adulthood.Materials and Methods:PubMed, EMBASE, and Cochrane CENTRAL Register were searched for randomized controlled trials (RCT) comparing systolic and diastolic blood pressures in individuals born preterm and those born full-term, from inception till April 11th, 2022. Data were extracted, pooled, and analyzed. Forest plots were created for a visual demonstration.Results:Twenty-eight studies were included in our meta-analysis. SBP and DBP across all categories (Mean, Ambulatory, Daytime, and Nighttime) were higher in the preterm group compared to the term group. Mean SBP, mean ambulatory SBP, mean daytime SBP and mean nighttime SBP were 4.26 mmHg [95% CI: 3.09–5.43;P< 0.00001], 4.53 mmHg [95% CI: 1.82–7.24;P= 0.001], 4.51 mmHg [95% CI: 2.56–6.74;P< 0.00001], and 3.06 mmHg [95% CI: 1.32–4.80;P= 0.0006] higher in the preterm group, respectively. Mean DBP, mean ambulatory DBP, mean daytime DBP, and mean nighttime DBP were 2.32 mmHg [95% CI: 1.35–3.29;P< 0.00001], 1.54 mmHg [95% CI 0.68–2.39;P= 0.0004], 1.74 mmHg [95% CI: 0.92–2.56;P< 0.0001], and 1.58 mmHg [95% CI: 0.34–2.81;P= 0.01] higher in the preterm group, respectively.Conclusion:Our observations suggest that individuals who were born preterm may have higher blood pressures as compared to those who were born full-term.