bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urologic perspective of genitourinary syndrome of menopause
Authors: González‐Arboleda Andrés Augusto , Arias‐Castillo Liliana , García‐Perdomo Herney Andrés 
Published: January 2024

AbstractBackgroundExperts define the Genitourinary Syndrome of Menopause (GSM) as a collection of signs and symptoms associated with decreased oestrogen levels. Its prevalence ranges between 13% and 87% in postmenopausal women.ObjectiveWe aimed to describe the main pathophysiology mechanisms of GSM affecting the lower urinary tract and the manifestations and treatment options for lower urinary tract dysfunction in GSM.ResultsSeveral treatments and recommendations have been proposed to enhance patients' ability to manage their symptoms, such as regular sexual activity or masturbation, to increase this physiological response and reduce the severity of GSM.ConclusionGSM is a multifactorial and complex syndrome that affects postmenopausal women. Impairment of urogenital structures implies diverse manifestations of genital atrophy and lower urinary tract symptoms.
Tail Fan Necrosis syndrome in decapod crustaceans: A review
Authors: Jones John Brian , Brosnahan Cara L. , Pande Anjali 
Published: January 2024

AbstractLobsters and crayfish in Australasia can develop a condition known as Tail Fan Necrosis (TFN syndrome). Many attempts have been made to find a primary pathogen or link the syndrome to commercial activities, but a solution remains elusive. TFN syndrome is a ‘wicked problem’, a problem difficult or impossible to solve because of incomplete and contradictory information forming a matrix of potential outcomes with no simple solution. Reviewing the literature shows TFN syndrome is sometimes reported to develop in association with sterile blisters on the telson and uropods which may rupture permitting invasion by environmental fungal and/or bacterial flora. Whether blisters form prior to, or because of, infection is unknown. TFN syndrome sometimes develops in captivity, sometimes requires a previous insult to the telson and uropods, and prevalence is patchy in the wild. The literature shows the cause of blisters associated with TFN syndrome remains an enigma, for which we suggest several possible initiating factors. We strongly urge that researchers not ‘jump to conclusions’ as to the aetiology of TFN syndrome. It cannot be explained without carefully exploring alternative aetiologies whilst being cognisant of the age‐old lesson that ‘correlation does not equal causation’.
Assessing performance of Geriatric Surgery Verification Program preoperative communication standards in spine surgery
Authors: Agaronnik Nicole D. , Streid Jocelyn L. , Kwok Anne , Schoenfeld Andrew J. , Cooper Zara , Lindvall Charlotta 
Published: January 2024

AbstractBackgroundTo assess performance of the American College of Surgeons Geriatric Surgery Verification (GSV) Program preoperative communication standards in older patients undergoing high risk spine surgery.MethodsWe performed an external validation of a natural language processing (NLP) method for identifying documentation meeting GSV communication standards. We then applied this method to a retrospective cohort of patients aged 65 and older who underwent spinal fusion procedures between January 2018–December 2020 in a large healthcare system in Massachusetts. Our primary outcome of interest was fulfillment of GSV communication domains: overall health goals, treatment goals, and patient‐centered outcomes. Factors associated with the fulfillment of at least one domain were assessed using Poisson regression to adjust for confounding.ResultsExternal validation of the NLP method had a sensitivity of 88.6% and specificity of 99.0%. Our study population included 1294 patients, of whom only 0.8% (n = 10) patients contained documentation of all three GSV domains, and 33.7% (n = 436) had documentation fulfilling at least one GSV domain. The GSV domain with lowest frequency of documentation was overall health goals, with only 35 (2.7%) of patients meeting this requirement. Adjusted analysis suggested that patients with a Charlson comorbidity score of one or more had higher fulfillment of GSV criteria (CCI 1–3: prevalence rate ratio (PRR) 1.8, 95% confidence interval (CI) 1.5–2.1; CCI >3: PRR 1.5, 95% CI 1.2–1.9).ConclusionA paucity of geriatric patients undergoing spine surgery had preoperative documentation consistent with GSV standards. Given that spine surgery is one of the highest risk surgeries in older adults and GSV standards are relevant to all surgical specialties, wider promulgation of these standards is warranted.
Effect of water type and proofing method on the perceived taste/mouthfeel properties of distilled spirits
Authors: Wang Zhuzhu , Cadwallader Keith R. 
Published: January 2024

AbstractWater is a key ingredient used in proofing of distilled spirits; however, its impact on the sensory perception of distilled spirits after proofing is scarcely reported. In this study, we diluted both aged and unaged spirits from high proof (>55%, alcohol by volume, ABV) down to 40% ABV and used a trained panel to determine if the choice of water type (spring water, distilled water, or limestone water) and proofing method (fast‐ vs. slow‐proofing) affected the perceived taste/mouthfeel characteristics of the final diluted spirits. Results showed that water type and proofing method did not have a significant effect on aged spirits. However, proofing method but not water type had a significant effect on the sensory perception of unaged spirits. Further characterization on the dynamic sensory profiles of fast‐ vs slow‐proofed unaged spirits showed that the slow‐proofed unaged spirits were characterized as sweeter at the beginning, with less burn throughout the entire evaluation period.Practical ApplicationTo our knowledge, this is the first demonstration of using A‐Not A test method to determine whether a perceived difference exists between two confusable high alcohol containing beverages. Our findings are of particularly relevance to producers of unaged spirits (i.e., vodkas), as it illustrates the importance of proofing strategies and how they can help to reduce the ethanol related burn sensation in unaged spirits when no other influential congeners are present.
Exploring the potential of the Vanilla species from the Brazilian Atlantic Forest: Sensory description and consumer acceptance
Authors: Franco Juliana Lacôrte , Ayres Ellen Mayra Menezes , de Oliveira Denize , Martins Inayara Beatriz Araujo , Macedo Andrea Furtado , Deliza Rosires , Koblitz Maria Gabriela Bello 
Published: January 2024

AbstractThe present work aimed to explore, for the first time, the sensory potential of three native species of Vanilla collected in the Brazilian Atlantic Forest (V. bahiana, V. chamissonis, V. cribbiana). Ethanolic extracts of vanilla species were obtained from the ripe, enzymatically cured pods, and added to lactose‐free milk making vanilla flavored milk samples. Threshold estimation differences of “vanilla flavor,” and hedonic and sensory consumer perception of samples were evaluated. A 9‐point hedonic scale and the Rate‐All That‐Apply methodology were used for comparison to the commercial species (V. planifolia) and an artificial essence. All native species showed lower average threshold concentrations than the commercial species extract. There was no significant difference in the perception of “vanilla aroma” between V. cribbiana and the commercial species, and neither V. cribbiana nor V. chamissonis showed significant difference to the artificial essence or V. planifolia extract for “sweet taste.” Among the evaluated species, V. cribbiana seemed to show the greatest potential for market success.Practical ApplicationsThe species of Vanilla sp. explored in this work have already been chemically evaluated and presented the components related to the vanilla flavor. However, the mere presence of chemical compounds does not guarantee aroma perception. Their relative concentrations, among other factors that are difficult to determine chemically, are indispensable for generating an agreeable flavor. The only reliable way to determine the acceptability of the flavor is through sensory analysis, applied in this work to prove the commercial potential of native species. Vanilla species native to the Atlantic Forest showed the sensory potential to be used as substitutes for commercial species and to be applied in the genetic improvement of varieties. These native species may be introduced to “gourmet” consumers as vanilla flavors with different nuances. Their production may favor the areas where they are cultivated, bringing economic development to the population, and helping to maintain the forest areas.
The evolving phenotype of autoimmune hepatitis across the millennium: The 40‐year experience of a referral centre in Italy
Authors: Ferronato Marco , Lalanne Claudine , Quarneti Chiara , Panico Maria Luisa , Guidi Marcello , Lenzi Marco , Muratori Luigi 
Published: January 2024

AbstractBackground and AimsDuring recent years, there have been major insight into the pathogenesis, diagnosis and treatment of autoimmune hepatitis (AIH). We aim to evaluate modifications of the clinical‐epidemiological phenotype of AIH patients from 1980 to our days.MethodsSingle‐centre, tertiary care retrospective study on 507 consecutive Italian patients with AIH. Patients were divided into four subgroups according to the decade of diagnosis: 1981–1990, 1991–2000, 2001–2010 and 2011–2020. We assessed clinical, laboratory and histological features at diagnosis, response to treatment and clinical outcomes. Acute presentation is defined as transaminase levels >10‐fold the upper limit and/or bilirubin >5 mg/dL. Complete response is defined as the normalization of transaminases and IgG after 12 months. Clinical progression is defined as the development of cirrhosis in non‐cirrhotic patients and hepatic decompensation/hepatocellular carcinoma development in compensated cirrhosis.ResultsMedian age at diagnosis increased across decades (24, 31, 39, 52 years, p < .001). Acute onset became more common (39.6%, 44.4%, 47.7%, 59.5%, p = .019), while cirrhosis at diagnosis became less frequent (36.5%, 16.3%, 10.8%, 8.7%, p < .001). Complete response rates rose (11.1%, 49.4%, 72.7% 76.2%, p < .001) and clinical progression during follow‐up decreased (54.3%, 29.9%, 16.9%, 11.2%, p < .001). Anti‐nuclear antibodies positivity increased (40.7%, 52.0%, 73.7%, 79.3%, p < .001), while IgG levels/upper limit progressively decreased (1.546, 1.515, 1.252, 1.120, p < .001). Liver‐related death and liver transplantation reduced from 17.1% to 2.1% (p < .001).ConclusionsIn the new millennium, the typical AIH patient in Italy is older at diagnosis, more often presents with acute hepatitis, cirrhosis is less frequent and response to treatment is more favourable.
Molecular distribution and 13C isotope composition of volatile organic compounds in the Murchison and Sutter's Mill carbonaceous chondrites
Authors: Aponte José C. , Séguin Frédéric , Siguelnitzky Ariel J. , Dworkin Jason P. , Elsila Jamie E. , Glavin Daniel P. , Connolly Harold C. , Lauretta Dante S. 
Published: January 2024

AbstractVolatile organic compounds (VOCs) are carbon‐containing chemicals that may evaporate rapidly at room temperature and standard pressure. Such organic compounds can be preserved inside carbonaceous chondrite matrices. However, unlike meteoritic soluble organic matter (SOM) and insoluble organic matter (IOM), VOCs are typically lost (at least in part) during sample processing (meteorite crushing) and exposure to terrestrial atmosphere and/or solvents. Like SOM and IOM, VOCs can provide valuable insights into the chemical inventory of the meteorite parent body and even the presolar cloud from which our solar system formed, as well as the composition and processes that occurred during the early formation of our solar system and the asteroidal stage. Thus, in this work, we designed and built an instrument that allowed us to access the VOCs present in samples of the carbonaceous chondrites Murchison and Sutter's Mill after mineral disaggregation by means of freeze–thaw cycling. We simultaneously evaluated the abundances and compound‐specific 13C‐distributions of the volatiles evolving after meteorite powdering at ~20, 60, and 100°C. Carbon monoxide (CO) and methane (CH4) were released from these meteorites as the most abundant VOCs. They were combusted together for analysis and showed positive δ13C values, indicative of their extraterrestrial origins. Carbon dioxide (CO2) was also an abundant VOC in both meteorites, and its isotopic values suggest that it was mainly formed from dissolved carbonates in the samples. We also detected aldehydes, ketones, and aromatic compounds in low amounts. Contrary to Murchison, which mostly yielded VOCs with positive δ13C values, Sutter's Mill yielded VOCs with negative δ13C values. The less enriched 13C isotope composition of the VOCs detected in Sutter's Mill suggest that they are either terrestrial contaminants, such as VOCs in compressed gas dusters and common laboratory solvents, or compounds disconnected from interstellar sources and/or formed through parent body processing. Understanding the relative abundances and determining the molecular distributions and isotopic compositions of free meteoritic VOCs are key in assessing their extraterrestrial origins and those of chondritic SOM and IOM. Our newly developed technique will be valuable in the study of the samples brought to the Earth from carbonaceous asteroid Bennu by NASA's OSIRIS‐REx mission.
Focused‐beam X‐ray fluorescence and diffraction microtomographies for mineralogical and chemical characterization of unsectioned extraterrestrial samples
Authors: Lanzirotti Antonio , Sutton Stephen R. , Newville Matthew , Brearley Adrian , Tschauner Oliver 
Published: January 2024

AbstractThis study describes the application of new synchrotron X‐ray fluorescence (XRF) and diffraction (XRD) microtomographies for the 3‐D visualization of chemical and mineralogical variations in unsectioned extraterrestrial samples. These improved methods have been applied to three compositionally diverse chondritic meteorite samples that were between 300 and 400 μm in diameter, including samples prepared from fragments of the CR2 chondrite LaPaz Icefield (LAP) 02342, H5 chondrite MacAlpine Hills (MAC) 88203, and the CM2 chondrite Murchison. The synchrotron‐based XRF and XRD tomographies used are focused‐beam techniques that measure the intensities of fluorescent and diffracted X‐rays in a sample simultaneously during irradiation by a high‐energy microfocused incident X‐ray beam. Measured sinograms of the emitted and diffracted intensities were then tomographically reconstructed to generate 2‐D slices of XRF and XRD intensity through the sample, with reconstructed pixel resolution of 1–2 μm, defined by the resolution of the focused incident X‐ray beam. For sample LAP 02342, primary mineral phases that were visualized in reconstructed slices using these techniques included isolated grains of α‐Fe, orthopyroxene, and olivine. For our sample of MAC 88203, XRF/XRD tomography allowed visualization of forsteritic olivine as a primary mineral phase, a vitrified fusion crust at the sample surface, identification of localized Cr‐rich spinels at spatial resolutions of several micrometers, and imaging of a plagioclase‐rich glassy matrix. In the sample of Murchison, major identifiable phases include clinoenstatite‐ and olivine‐rich chondrules, variable serpentine matrix minerals and small Cr‐rich spinels. Most notable in the tomographic analysis of Murchison is the ability to quantitatively distinguish and visualize the complex mixture of serpentine‐group minerals and associated tochilinite–cronstedtite intergrowths. These methods provide new opportunities for spatially resolved characterization of sample texture, mineralogy, crystal structure, and chemical state in unsectioned samples. This provides researchers an ability to characterize such samples internally with minimal disruption of sample micro‐structures and chemistry, possibly without the need for sample extraction from some types of sampling and capture media.
Impact of the Metacognitive Educational Program Cogni'Scol on the Academic Success of Middle School Students
Authors: Allix Pauline , Lubin Amélie , Lanoë Céline , Mortier Arnaud , Rossi Sandrine 
Published: January 2024

AbstractWhat can be done to promote the academic success of learners? More than a question, it is a major challenge of our time. In this perspective, metacognition seems to be a way to empower learners to take ownership of their academic success. Considering the recommendations established in the literature, we co‐constructed with teachers a metacognitive educational program, called Cogni'Scol, based on brain functioning in learning. Its benefits were determined through a longitudinal study focusing on the academic success of French students. We followed sixth grade students over a two‐year period who either benefited or not from a weekly session of the Cogni'Scol program. Results showed a significant effect on students' knowledge and representations of brain functioning but not on the students' academic performances mediated by improvements in their metacognition. We conclude with pragmatic reflections for researchers and educational professionals interested in the implementation of educational programs based on brain functioning in learning.
Modelling and forecasting India's electricity consumption using artificial neural networks
Authors: Bandyopadhyay Arunava , Sarkar Bishal Dey , Hossain Md. Emran , Rej Soumen , Mallick Mohidul Alam 
Published: January 2024

AbstractPrecise electricity forecasting is a pertinent challenge in effectively controlling the supply and demand of power. This is due to the inherent volatility of electricity, which cannot be stored and must be utilised promptly. Thus, this study develops a framework integrating canonical cointegrating regressions (CCR), time series artificial neural network (ANN) and a multilayer perceptron ANN model for analysing and projecting India's gross electricity consumption to 2030. Annual data for the years 1961–2020 have been collected for variables like gross domestic product (GDP), population, inflation GDP deflator (annual %), annual average temperature and electricity consumption. The study was conducted in three phases. In the first phase of the study, the CCR method was used to check the significance of the selected variables. In the second phase, the projected values of independent variables (GDP, population, inflation GDP deflator [annual %] and annual average temperature) were predicted using the time series ANN model. Finally, a multilayer perceptron ANN model with independent variables was used to forecast the gross electricity consumption in India by 2030. The result shows that the electricity consumption in India will increase by around 50% in the next 10 years, reaching over 1800 TWh in 2030. The proposed approach can be utilised to effectively implement energy policies, as an accurate prediction of energy consumption can help capture future demand.
The effect of marsupialization of large cystic lesions of the jaws on pulp vitality
Authors: Fidele Nyimi Bushabu , Zinio Mabanza Julia , Titinchi Fadi , Zhi‐Jun  , Inganya Ekofo Edize , Bing Liu 
Published: January 2024

AbstractIntroductionThere is a paucity of studies evaluating the preservation and recovery vitality of teeth associated with cystic lesions in the jaws.The purpose of the present study was to evaluate whether the use of the marsupialization treatment method in the large cystic lesions of the jaws associated within involved teeth would save the pulp vitality.Materials and methodsIt was a cohort study of patients treated at the Department of Oral and Maxillofacial Surgery from April 2019 to April 2023. Patients with primary cystic lesions associated teeth, with a cyst diameter of >3.4 cm, along with dental root resorption of less than half the root length, and treated by marsupialization were included. Patient age, gender, location, associated teeth, size, management, dental pulp vitality before and after marsupialization, and the duration of treatment were evaluated. Pulp vitality of involved teeth was assessed with electrical pulp tester.Predictor VariableIt was the treatment method.Main Outcome Variable(s)The primary outcome variable was the recovery or preservation of pulp vitality.CovariatesThe study variables were demographic, clinical features of the cysts, clinical features of associated teeth, and treatment method.AnalysesCategorical data were presented in mean with standard deviation, and set the level of statistical significance at p < 0.05.ResultsThe sample included 73 patients with large cystic lesions; 47 (64.4%) were male and 26 (35.6%) were female. The age range was 9 to 68 years (mean ± standard deviation, 22.4 ± 4). The 73 patients had 305 teeth associated with large cystic lesions. Of these dentitions, 85.9% of teeth had normal pulp vitality and 14.1% were negative before marsupialization. Following marsupialization, preservation of pulp vitality was noted in 61.3% and 18.0% of teeth lost their vitality. Of those without normal dental pulp vitality, 70.9% of teeth recovered their vitality of which 46.5% had recovered their vitality 9 to 12 months following marsupialization.ConclusionMarsupialization followed by second surgery maybe a treatment option for preserving and recovering the pulp vitality of teeth associated with large cystic jaw lesions.
Novel synthetic inducible promoters controlling gene expression during water‐deficit stress with green tissue specificity in transgenic poplar
Authors: Yang Yongil , Chaffin Timothy A. , Shao Yuanhua , Balasubramanian Vimal K. , Markillie Meng , Mitchell Hugh , Rubio‐Wilhelmi Maria M. , Ahkami Amir H. , Blumwald Eduardo , Neal Stewart C. 
Published: January 2024

SummarySynthetic promoters may be designed using short cis‐regulatory elements (CREs) and core promoter sequences for specific purposes. We identified novel conserved DNA motifs from the promoter sequences of leaf palisade and vascular cell type‐specific expressed genes in water‐deficit stressed poplar (Populus tremula × Populus alba), collected through low‐input RNA‐seq analysis using laser capture microdissection. Hexamerized sequences of four conserved 20‐base motifs were inserted into each synthetic promoter construct. Two of these synthetic promoters (Syn2 and Syn3) induced GFP in transformed poplar mesophyll protoplasts incubated in 0.5 M mannitol solution. To identify effect of length and sequence from a valuable 20 base motif, 5′ and 3′ regions from a basic sequence (GTTAACTTCAGGGCCTGTGG) of Syn3 were hexamerized to generate two shorter synthetic promoters, Syn3‐10b‐1 (5′: GTTAACTTCA) and Syn3‐10b‐2 (3′: GGGCCTGTGG). These promoters' activities were compared with Syn3 in plants. Syn3 and Syn3‐10b‐1 were specifically induced in transient agroinfiltrated Nicotiana benthamiana leaves in water cessation for 3 days. In stable transgenic poplar, Syn3 presented as a constitutive promoter but had the highest activity in leaves. Syn3‐10b‐1 had stronger induction in green tissues under water‐deficit stress conditions than mock control. Therefore, a synthetic promoter containing the 5′ sequence of Syn3 endowed both tissue‐specificity and water‐deficit inducibility in transgenic poplar, whereas the 3′ sequence did not. Consequently, we have added two new synthetic promoters to the poplar engineering toolkit: Syn3‐10b‐1, a green tissue‐specific and water‐deficit stress‐induced promoter, and Syn3, a green tissue‐preferential constitutive promoter.