bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma Based on Integration Analysis of TCGA/ICGC
Databases and Single-cell Sequencing
Authors: Huang Zupin , Li Zhuokai , Lv Xinliang , Tan Wei 
Published: February 2024

Background:
Hepatocellular Carcinoma (HCC) is closely linked to inflammatory
reactions, with chronic liver diseases acting as major risk factors. In the inflammatory microenvironment,
repeated damage and repair of liver cells lead to genetic mutations, abnormal proliferation,
and tumorigenesis.

Objective:
This study aimed to investigate the expression profile of specific cell clusters under
inflammatory stimulation in HCC and identify potential therapeutic drugs.

Methods:
Comprehensive analysis of HCC transcriptome data and single-cell sequencing data
from TCGA, ICGC, and GEO databases was conducted to explore the specific molecular mechanisms
of epithelial cells. Virtual screening of natural compounds in the ZINC database and in
vitro cell experiments were performed to identify drugs that regulate the expression of inflammatory
factors in epithelial cells.

Results:
Analysis of the single-cell dataset revealed cell clusters closely associated with HCC,
notably Epithelial cells, Hepatocytes, MSC, and iPS cells, with Epithelial cells playing a pivotal
role in HCC development. Further investigation of TCGA data unveiled 83 differentially
expressed genes (DEGs) related to inflammatory responses in HCC. Intersection analysis
of DEGs in epithelial cells and HCC DEGs identified 12 common DEGs, including ADRM1,
ATP2B1, FZD5, GPC3, KIF1B, KLF6, LY6E, MET, NAMPT, SERPINE1, SPHK1, and
SRI. Prognostic analysis revealed that CCL7, GPR132, ITGB8, PTAFR, SELL, and VIP were
influential in the survival prognosis of HCC. A prognostic model based on the expression
levels of these genes demonstrated an increased risk of HCC associated with higher differential
expression of inflammatory response genes. Additionally, molecular dynamics simulations
indicated that compounds NADH and Deferoxamine formed stable docking models
with the inflammatory protein VIP, suggesting their potential as candidates for targeted
therapy.

Conclusion:
Inflammatory factors CCL7, GPR132, ITGB8, PTAFR, SELL, and VIP influence
the inflammatory cascade response in HCC epithelial cells, and their expression correlates
with the survival prognosis of HCC patients. Interfering with VIP expression effectively
suppresses proliferation, migration, and invasion of HCC cells, as well as inhibiting the
occurrence of inflammatory cascade reactions, thus slowing down the progression of hepatocellular
carcinoma. Furthermore, compounds NADH and Deferoxamine have the potential to
target and bind to the inflammatory protein VIP, highlighting their relevance in potential HCC
treatment.
Investigating the Relationship between COVID-19 In-hospital Death and
Acute Kidney Injury
Authors: Haghighi Ramin , Fereyduny Nikoo , Oghazian Mohammad Bagher , Haghighi Ashkan , Bigdeli Amir , Sahebkar Amirhossein 
Published: February 2024

Introduction:
Coronavirus Disease 2019 (COVID-19) can induce multiorgan failure, including
acute kidney injury (AKI), which is associated with a poor prognosis. Some of these patients
develop proteinuria, hematuria, and elevated serum creatinine, therefore some require hemodialysis.
This study aimed to investigate the association between in-hospital death due to COVID-19 and the
incidence of AKI.

Methods:
In a retrospective study, the available data of patients who died because of COVID-19
from April 1 to September 22, 2020 in a referral hospital was investigated using the case census
method.

Results:
A total of 190 patients who died of COVID-19 were evaluated. Of these, 111 (58.42%) had
AKI, with 108 (56.84%) being male. The mean age of the subjects was 66.16±15.43 years old. The
mean time from hospital admission to death was about 9 days in all patients. Although not statistically
significant, the findings showed that patients who developed AKI died sooner. The most frequent
underlying diseases were hypertension [n= 101 (53.16%)] and diabetes [n= 44 (23.16%)]. Moreover,
a higher proportion of subjects with AKI as compared to those without AKI were admitted to the
intensive care unit (ICU), and had abnormal proteinuria profile (p-value=0.045 and 0.025, respectively).

Conclusion:
The incidence of AKI was 58.42% in patients who died from COVID-19 disease.
Moreover, abnormal proteinuria and ICU admission were significantly higher in COVID-19 patients
with AKI than in those without AKI.
PRISLAMISM, RADICALIZATION AND DERADICALIZATION IN CANADA
Authors: Shaikh Mubin 
Published: February 2024

On November 13, 2023, Professor Mubin Shaikh presented Prislamism, Radicalization, and Deradicalization in Canada at the West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were that Prislamism, thought of as a route to radicalization, is a blend of Islamic theory and concepts that advocates for violence toward institutions of incarceration. The prison systems in both Muslim and Western nations provide a breeding ground for radicalization through both their physical conditions and the social dynamics of custody. Combating radicalization in prisons requires robust training and a steadfast adherence to the law on the part of practitioners.

Received: 12-11-2023
Revised: 01-26-2024
JOINT INTEROPERABILITY AND THE IMPORTANCE OF STRATEGIC COORDINATION GROUPS
Authors: Price Liam 
Published: February 2024

On November 14, 2023, Director General Liam Price, International Special Services, International Policing, Royal Canadian Mounted Police (RCMP), presented Joint Interoperability and the Importance of Strategic Coordination Groups for this year’s West Coast Security Conference. The key points discussed were that the nature of criminality is evolving to increasingly encompass cross-border, technologically adept, and highly adaptable strategies, and policing organizations must advance and expand their tactics and training to create effective solutions. This involves creating common legal frameworks, emphasizing shared policing values and enhancing information sharing capabilities.

Received: 12-18-2023
Revised: 01-26-2024
DEVELOPING THEORY ON THE INSURGENT USE OF INTELLIGENCE
Authors: Strachan-Morris David 
Published: February 2024

On November 15, 2023, Dr. David Strachan-Morris, presented on Developing Theory on the Insurgent Use of Intelligence for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were uncertainty towards the global threat environment, counterintelligence strategies in vulnerable regions, and the treatment of intelligence as a public good.

Received: 12-30-2023
Revised: 01-26-2024
BALANCING NATIONAL SECURITY INTERESTS WITH PRIVACY, THE CHARTER AND RULE OF LAW: BUILDING CHECKLISTS INTO OPERATION PLANNING
Authors: Dubois Justin 
Published: February 2024

On November 17, 2023, Justin Dubois, Executive Director and General Counsel of the Office of the Intelligence Commissioner, presented Balancing National Security Interests with Privacy, the Charter and Rule of Law: Building Checklists into Operation Planning for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the Intelligence Commissioner Act, the role of the Intelligence Commissioner in providing quasi-judicial review of certain activities of intelligence agencies, and the Intelligence Commissioner’s use of the principles of necessity, proportionality, and reasonableness to guide its decision-making process.

Received: 01-04-2024
Revised: 01-29-2024
Development and Usability Testing of a Mobile App–Based Clinical Decision Support System for Delirium: Randomized Crossover Trial
Authors: Wang Jiamin , Ji Meihua , Han Yuan , Wu Ying 
Published: February 2024

Abstract

Background
The 3-Minute Diagnostic Interview for Confusion Assessment Method–Defined Delirium (3D-CAM) is an instrument specially developed for the assessment of delirium in general wards, with high reported sensitivity and specificity. However, the use of the 3D-CAM by bedside nurses in routine practice showed relatively poor usability, with multiple human errors during assessment.

Objective
This study aimed to develop a mobile app–based delirium assessment tool based on the 3D-CAM and evaluate its usability among older patients by bedside nurses.

Methods
The Delirium Assessment Tool With Decision Support Based on the 3D-CAM (3D-DST) was developed to address existing issues of the 3D-CAM and optimize the assessment process. Following a randomized crossover design, questionnaires were used to evaluate the usability of the 3D-DST among older adults by bedside nurses. Meanwhile, the performances of both the 3D-DST and the 3D-CAM paper version, including the assessment completion rate, time required for completing the assessment, and the number of human errors made by nurses during assessment, were recorded, and their differences were compared.

Results
The 3D-DST included 3 assessment modules, 9 evaluation interfaces, and 16 results interfaces, with built-in reminders to guide nurses in completing the delirium assessment. In the usability testing, a total of 432 delirium assessments (216 pairs) on 148 older adults were performed by 72 bedside nurses with the 3D-CAM paper version and the 3D-DST. Compared to the 3D-CAM paper version, the mean usability score was significantly higher when using the 3D-DST (4.35 vs 3.40; P<.001). The median scores of the 6 domains of the satisfactory evaluation questionnaire for nurses using the 3D-CAM paper version and the 3D-DST were above 2.83 and 4.33 points, respectively (P<.001). The average time for completing the assessment reduced by 2.1 minutes (4.4 vs 2.3 min; P<.001) when the 3D-DST was used.

Conclusions
This study demonstrated that the 3D-DST significantly improved the efficiency of delirium assessment and was considered highly acceptable by bedside nurses.
Controllable Cetrimide – Assisted Hydrothermal Synthesis of MoFe<sub>2</sub>O<sub>4</sub> and Coupling with Al<sub>2</sub>O<sub>3</sub> as an Effective Photocatalyst for Decolorization of Indigo Carmine Dye
Authors: Hameed Mohammed Ali , Ahmed Luma Majeed 
Published: February 2024

This research focuses on the MoFe2O4 nanoparticles synthesized via the hydrothermal method in the presence of positive surfactant- Cetrimide (CT) as a template and stabilizer. This is vital to prevent the agglomeration and reducing its activity. The mean crystal sizes of MoFe2O4 and its composite with alumina system were observed to be 23.97 and 47.41 nm, respectively. The shapes of MoFe2O4 and its composite are nanoplate and like-popcorn nanoparticles. The EDX spectra demonstrated that the MoFe2O4 and its composite are truly synthesized with high purity. The FTIR proved the MoFe2O4 is normal spinel. Based on the Tauc equation, band gaps were measured and found to be 2.78 and 4.05 eV for MoFe2O4 and its nanocomposite. The photo decolorization efficiency (PDE) of indigo carmine dye (IC) using MoFe2O4 nanoparticles and its nanocomposite was discovered to be 90.84 and 91.50%, respectively, at pH 5.3, 10 °C for 50 min. This photoreaction obeys the pseudo-first order, exothermic, spontaneous, and negative activation energy, that attitude to the multi-step occurs in chain reactions. This behavior depends on the speed of the binding step of the dye with Fe3+, Mo6+, or Al3+ in the crystal lattice of MoFe2O4 nanoparticle and its nanocomposite.
Energy Efficiency of the Carbonate Hydroxyapatite Nanoparticle Synthesis Using Microwave Heating Treatment and Its Effect on Material Characteristics
Authors: Aziz Saifuddin , Pranowo Harno Dwi , Ana Ika Dewi , Yusuf Yusril 
Published: February 2024

This work aimed to study the energy efficiency of the synthesis process of carbonated hydroxyapatite (CHA) nanoparticles using microwave heating treatment and its effect on material characteristics. Microwaves can provide heat quickly, so it is expected to increase the efficiency of CHA synthesis through the heat provided. The CHA nanoparticles were synthesized using precipitation and heated using a microwave oven. The unheated and hydrothermal-heated precipitation methods were also conducted for comparison purposes. The microwave-heated precipitations were done at 270 W for 0.05, 0.10, and 0.15 h, while the hydrothermal-heated precipitations were done at 100 °C for 1, 2, and 3 h. The CHA materials were characterized using an infrared spectrophotometer, X-ray diffractometer, and electron microscope. The X-ray diffractogram and infrared spectra confirmed that the synthesized materials had a hydroxyapatite crystal phase with a CO32− functional group in their spectra. Microscopic images revealed that the materials were nanometer-sized grain aggregates. The heat treatment and duration increased the material characteristics, i.e., crystallinity, crystallite, and grain size. The CHA with microwave heat treatment had the highest crystallinity and crystallite size. The electrical energy calculation revealed microwave heating had better energy efficiency than hydrothermal heating.
Molecular Docking and Molecular Dynamic Investigations of Xanthone-Chalcone Derivatives against Epidermal Growth Factor Receptor for Preliminary Discovery of Novel Anticancer Agent
Authors: Kurniawan Yehezkiel Steven , Yudha Ervan , Nugraha Gerry , Fatmasari Nela , Pranowo Harno Dwi , Jumina Jumina , Sholikhah Eti Nurwening 
Published: February 2024

Epidermal growth factor receptor (EGFR) is found to be overexpressed in cancer cells as it controls angiogenesis, cell signaling, and proliferation mechanisms. Therefore, EGFR has been known as a common target for the initial screening of new anticancer agents. Either xanthone or chalcone has been evaluated as the anticancer agents, and their activity strongly depends on the type and position of the attached functional group. Therefore, molecular hybridization between xanthone and chalcone could yield novel anticancer agents through the EGFR inhibition mechanism. Herein, a series of xanthone-chalcone derivatives with hydrogen-bond-acceptor or hydrogen-bond-donor substituents at ortho, meta, and para positions was evaluated as the EGFR inhibitor. Thirty-seven xanthone-chalcones were designed and docked in the active site of EGFR. Compared to the native ligand, pristine xanthone-chalcone gave a 1.215× stronger binding energy and a 13.97× lower binding constant. Compound 3SH was found to be the most promising candidate due to its strongest binding energy (−9.71 kcal/mol) and the lowest binding constant (0.08 µM). Furthermore, molecular dynamic studies demonstrated that complex EGFR-3SH was stable for 100 ns simulation. These in silico investigations show that the xanthone-chalcone derivative is a promising novel anticancer agent to be examined through in vitro and in vivo assays.
Dionysiac Art and Pastoral Escapism
Authors:   Binghamton University, Roth Casey 
Published: February 2024

As the Mediterranean cities expanded in an ever-more interconnected Hellenistic world, people longed for a rustic lifestyle because the urban landscape was seen to be engulfed by materialistic and vain concerns.<a title="">[1]</a> People faced many stresses in these urban centers and consequently searched for relief through art. How did Dionysiac art reflect political and social ideas and the identity of Hellenistic people through pastoralism? Pastoralism in art embodied the idea that satisfaction and carefreeness were attained through connecting with an environment unaffected by the calamity of the city. The countryside was populated by herdsmen and farmers, as well as the god Dionysus and his followers, including satyrs, and centaurs. These pastoral elements were associated with an idealistic way of living in that they described a utopia of sorts, one that provided an escape from the stresses of life in the city.<a title="">[2]</a> Ideals presented in Dionysiac art was utopian in all aspects, located in an ideal place (<em>eu-topos</em>) that overcame boundaries, both worldly and geographic (<em>ou-topos</em>), and allowed one to achieve an elevated state of mind in a pastoral <em>locus amoenus</em>.<a title="">[3]</a> The idealistic pastoral place filled with Dionysiac imagery was found where people welcomed natural resources, rather than vain amenities of the city, abandoning their identity as a city dweller for an identity defined by pastoralism. Dionysiac art provoked the viewer, such as the sleeping Hermaphroditus statue, confronting the viewer with boundary challenging issues—the world of ordinary versus the Dionysiac world, the pastoral world versus one’s own world.<a title="">[4]</a> Boundary challenging presented the idea of finding one’s way, integrating, and belonging, like mystery cults in which people found a new identity through participation in an escapist community.<a title="">[5]</a> Although people wanted to escape one aspect of their life, they found their way to something else of their own: the Dionysiac, pastoral world. <a title="">[1]</a> Alpers 1972, 354. <a title="">[2]</a> Witke 1966, 20. <a title="">[3]</a> Dang 2010, 120. <a title="">[4]</a> Von Stackelberg 2014, 398. <a title="">[5]</a> Bøgh 2015, 281.
Self-Compassion Increases Life Satisfaction in Singles Who Want to Get Married
Authors: Maryanto Gracetia Ratna Honesty , Himawan Karel Karsten , Akhtar Hanif 
Published: February 2024

For most societies with strong patriarchal values, marriage is part of cultural expectations, causing challenges and social stress for single individuals of marriageable age. This phenomenon can also be observed in people in Central Java. In an effort to increase the life satisfaction of single individuals amidst high cultural expectations, this quantitative study aims to explore the influence of self-compassion on life satisfaction. A cross-sectional survey was conducted on 138 single individuals aged between 25-35 years (Mage = 27.84; SD = 3.014). Regression analysis was utilized to determine the contribution of self-compassion to life satisfaction. The results show that self-compassion influences the life satisfaction of single women (r = .537; p = .000) and men (r = .270; p = .34) in Central Java. This means that self-compassion as a psychological strategy can help singles to experience life satisfaction even though they experience social pressure regarding their single status.

Bagi kebanyakan masyarakat dengan nilai patriarkal yang kuat, pernikahan merupakan bagian dari ekspektasi budaya, menyebabkan tantangan dan tekanan sosial bagi individu lajang berusia siap menikah. Fenomena ini juga dapat diobservasi pada masyarakat di Jawa Tengah. Sebagai upaya untuk meningkatkan kepuasan hidup individu lajang di tengah ekspektasi budaya yang tinggi, studi kuantitatif ini bertujuan untuk mengeksplorasi pengaruh welas asih diri terhadap kepuasan hidup. Survei cross-sectional dilakukan terhadap 138 individu lajang berusia antara 25-35 tahun (Musia = 27,84; SD = 3,014). Analisis regresi digunakan untuk mengetahui kontribusi welas asih diri terhadap kepuasan hidup. Hasil menunjukkan bahwa welas asih diri berpengaruh pada kepuasan hidup perempuan (r = 0,537; p = 0,000) dan laki-laki (r = 0,270; p = 0,34) lajang di Jawa Tengah. Hal ini berarti welas asih diri sebagai strategi psikologis dapat membantu lajang tetap mengalami kepuasan hidup walaupun mengalami tekanan sosial mengenai status lajangnya.
Ethics in Psychological Research and Publication: The Mocked Essentials
Authors: Jony Eko Yulianto  , Juneman Abraham  , Siaputra Ide Bagus 
Published: February 2024

In the realm of psychological research, ethics is paramount for upholding human dignity, adhering to the guiding principle of "do good and do no harm." Researchers bear the responsibility of ensuring that participants are well-informed about the research process, their rights to withdraw, and the protection of their identity and data confidentiality. In the era of Generative AI, it becomes increasingly crucial for researchers to recognize and avoid potential ethical deviations such as fabrication, falsification, conflicts of interest, and plagiarism. Regrettably, in Indonesia, formal ethical training often receives inadequate attention or is even perceived as a hindrance to research. Ethics should serve to maintain public trust in the value and validity of research. This editorial aims to provide practical principles, rather than stringent rules, to guide researchers. Special emphasis is placed on the importance of ethics beyond informed consent, including handling high-risk topics, utilizing confidential datasets, and engaging with vulnerable communities. The editorial elucidates the process of ethical clearance, outlines four major stages in research ethics, and offers seven recommendations pertaining to ethical fitness. This is to ensure theoretical contributions and adherence to high ethical standards in various research contexts.

Etika dalam penelitian psikologi adalah kunci untuk melindungi martabat manusia, mengikuti prinsip "berbuat baik dan tidak menyakiti." Peneliti bertanggung jawab memastikan peserta paham tentang proses penelitian, hak penarikan diri, serta kerahasiaan identitas dan data. Lebih anjut, di era AI Generatif, makin penting bagi peneliti untuk mengenali dan menghindari potensi penyimpangan berupa fabrikasi, falsifikasi, konflik kepentingan, plagiarisme, dan lainnya. Sayangnya, di Indonesia, pelatihan etika secara formal kurang diperhatikan atau bahkan sering dianggap menghambat penelitian. Etika seharusnya mempertahankan kepercayaan publik terhadap nilai dan validitas penelitian. Editorial ini bertujuan menyediakan prinsip-prinsip praktis, bukan hanya aturan ketat, untuk membimbing peneliti. Ada penekanan khusus terkait pentingnya etika selain persetujuan terinformasi, termasuk dalam topik berisiko tinggi, penggunaan dataset rahasia, dan bekerja dengan komunitas rentan. Editorial juga menjelaskan proses klirens etik, menguraikan empat tahapan utama dalam etika penelitian, dan memberikan tujuh rekomendasi terkait kelaikan etik. Hal ini untuk memastikan sumbangan teoretis dan kepatuhan terhadap standar etika tinggi dalam berbagai konteks penelitian.
Green Euphoria: Unraveling the Power of Sustainable Brands - Examining the Nexus of Green Brand Image, Authenticity, and Emotional Well-being with the Mediating Force of Green Brand Attachment
Authors: Manisa Khoirala Cindy , Alfansi Lizar 
Published: February 2024

Pupose: The study intends to examine the indirect relationship between green brand image and green brand authenticity on consumer emotional well-being through the mediating variable of green brand attachment.
Method: This study employs a quantitative-explanatory approach to examine the relationships between variables. The research focuses on consumers of environmentally friendly cosmetic products in Indonesia. The analysis utilized in this study is Structural Equation Modeling based on Partial Least Squares. The exact number of respondents analyzed in this research is 300 individuals who use environmentally friendly cosmetic products in Indonesia.
Result: The findings of this research indicate that Green Brand Authenticity (GA) and Green Brand Image (GBI) have a positive impact on Consumer Emotional Well Being (CWB). Similarly, Green Brand Authenticity (GA) and Green Brand Image (GBI) positively influence Green Brand Attachment (GBA). Green Brand Attachment positively affects Consumer Emotional Well Being (CWB). Green Brand Attachment (GBA) plays a partial mediating role in accommodating the relationship between Green Brand Authenticity (GA) and Green Brand Image (GBI) with Consumer Emotional Well Being (CWB).