bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, awareness, and patterns of non-steroidal anti-inflammatory drug use among health science students in Palestine: a cross-sectional study
Authors: Aboalrob Aseel I. , Eid Falasteen M. , Esa Saba M. , Koni Amer A. , Al-Jabi Samah W. , Zyoud Sa’ed H. 
Published: November 2023

AbstractDespite the widespread use of nonsteroidal anti-inflammatory drugs (NSAIDs), many people lack sufficient awareness regarding their side effects and proper usage. Consequently, this study aimed to assess the knowledge, behavior, and usage patterns of NSAIDs among students enrolled in Palestinian health colleges. The study was conducted in December 2020 using a cross-sectional design, and a convenience sampling method was employed to enroll a total of 206 students. The questionnaire comprised seven sections, each containing approximately 5 to 10 closed-ended questions. Data were analyzed using version 21 of the Statistical Package for the Social Sciences (IBM-SPSS Statistics 21). The percentage of respondents who admitted that NSAIDs were used several times in the year was 35.9%. More than half of the students believed that NSAIDs were generally safe. Seventy-two percent of the students were aware that more than one type of NSAID at the same time increased the side effects. The median knowledge score of NSAID side effects was 9 [6.25–11] out of 13. The knowledge score increased significantly with age (p < 0.001), higher academic year (p < 0.001), and pharmacy and medicine specialties (p = 0.002). The college students surveyed in this study possess a general awareness of NSAIDs. Nonetheless, there remains a necessity to enhance their behavior and practices concerning the utilization of NSAIDs through the implementation of programmed educational strategies.
Extreme diversity of 12 cations in folding ALS-linked hSOD1 unveils novel hSOD1-dependent mechanisms for Fe2+/Cu2+-induced cytotoxicity
Authors: Lim Liangzhong , Kang Jian , Song Jianxing 
Published: November 2023

Abstract153-Residue copper-zinc superoxide dismutase 1 (hSOD1) is the first gene whose mutation was linked to FALS. To date, > 180 ALS-causing mutations have been identified within hSOD1, yet the underlying mechanism still remains mysterious. Mature hSOD1 is exceptionally stable constrained by a disulfide bridge to adopt a Greek-key β-barrel fold that accommodates copper/zinc cofactors. Conversely, nascent hSOD1 is unfolded and susceptible to aggregation and amyloid formation, requiring Zn2+ to initiate folding to a coexistence of folded and unfolded states. Recent studies demonstrate mutations that disrupt Zn2+-binding correlate with their ability to form toxic aggregates. Therefore, to decode the role of cations in hSOD1 folding provides not only mechanistic insights, but may bear therapeutic implications for hSOD1-linked ALS. Here by NMR, we visualized the effect of 12 cations: 8 essential for humans (Na+, K+, Ca2+, Zn2+, Mg2+, Mn2+, Cu2+, Fe2+), 3 mimicking zinc (Ni2+, Cd2+, Co2+), and environmentally abundant Al3+. Surprisingly, most cations, including Zn2+-mimics, showed negligible binding or induction for folding of nascent hSOD1. Cu2+ exhibited extensive binding to the unfolded state but led to severe aggregation. Unexpectedly, for the first time Fe2+ was deciphered to have Zn2+-like folding-inducing capacity. Zn2+ was unable to induce folding of H80S/D83S-hSOD1, while Fe2+ could. In contrast, Zn2+ could trigger folding of G93A-hSOD1, but Fe2+ failed. Notably, pre-existing Fe2+ disrupted the Zn2+-induced folding of G93A-hSOD1. Comparing with the ATP-induced folded state, our findings delineate that hSOD1 maturation requires: (1) intrinsic folding capacity encoded by the sequence; (2) specific Zn2+-coordination; (3) disulfide formation and Cu-load catalyzed by hCCS. This study unveils a previously-unknown interplay of cations in governing the initial folding of hSOD1, emphasizing the pivotal role of Zn2+ in hSOD1-related ALS and implying new hSOD1-dependent mechanisms for Cu2+/Fe2+-induced cytotoxicity, likely relevant to aging and other diseases.
A feasibility analysis of image approximation with image quality assessments
Authors: Rahman Md. Abdur , Huq Aminul , Tunny Salma Sultana , Anik Maruf Hossain , Pervin Mst Tasnim , Islam Md. Rashidul 
Published: November 2023

AbstractWith technological developments, the resolution of the display systems is increasing, causing image data to increase. Several technologies are aiding in optimizing these data during transmission and storage while maintaining quality. Still, the internal data transmission for accessing the memory sub‐system during reading and writing cycles consumes significant power while requiring large memory for storage, which is inefficient, especially for portable displays. Hence, this work investigates the feasibility of reducing data through approximation for images in different formats and resolutions for human and computer vision based applications. Different image quality assessment metrics are utilized for performance evaluations with optimum image quality assessment selection according to application requirements. In addition, the feasibility analysis is conducted for three different applications as examples of computer vision. The experimental analysis highlights theoretical and industrial importance by showing that image data can be reduced from 25.0% to 62.5%, while satisfying requirements for HVS‐based and computer vision‐based applications.
Time domain response of corrugated transmission lines
Authors: Wu Chia Ho , Wang Wei , Peng Song Tsuen , Qian Zhenyu , Shen Jianqi , Ye Guoqiang , Ni Donghua , He Fang , Shen Linfang , Quan Bisheng , Jiao Yajie 
Published: November 2023

AbstractIn order to employ periodic corrugated microstrip lines for reducing or suppressing electromagnetic interference in high‐speed or high‐frequency circuits, a precise method is necessary to calculate and measure the characteristic impedance of periodic microstrip lines. The equation for characteristic impedance (depending on frequency) of lossless periodic microstrip lines was obtained based on the transfer matrix method. A time domain pulse was used to measure the instantaneous impedance of conventional microstrip lines, and when the instantaneous impedance does not change with distance, it can be identified as the characteristic impedance of microstrip lines. However, when the time‐domain pulses are employed to measure the instantaneous impedance of periodic microstrip lines, rapid oscillations occur with distance. Therefore, a standard for spacing between adjacent grooves in the microstrip line can be suggested by analysing the interaction between the time‐domain pulses and the microstrip line grooves. Once such a standard is satisfied, many grooves etched along the microstrip line would no longer be distinguished by the time‐domain pulses. Such a principle and method can be used to determine the instantaneous impedance for the microstrip lines that have periodic grooves. On the other hand, when several periodic structures with different lattice constants coexist on a microstrip line, they can also be distinguished via the instantaneous impedance. A time domain reflectometer was used for measuring the instantaneous impedance of periodic microstrip lines, and the measured results are in agreement with the theoretical analysis.
Wideband single‐fed circularly polarised patch antenna
Authors: Zhang Liang , Chen Jia , Wang Wenning , Qi Zihang , Ding Tongyu 
Published: November 2023

AbstractA two‐layered wideband single‐fed circularly polarised (CP) antenna is presented by the authors. A single‐fed corner‐truncated square patch with four identical rectangular matching branches acts as a bottom‐driven patch to generate CP radiation. To broaden the 3‐dB axial ratio (AR) bandwidth, a similar patch with a larger size is loaded atop the driven patch as a parasitic patch. The measured results show that the proposed CP antenna has a 17.9% impedance bandwidth from 2.13 to 2.55 GHz and an 11% 3‐dB AR bandwidth from 2.15 to 2.4 GHz, respectively. The measured total gain is 7.1 dBic. The results indicate that the proposed antenna is a good candidate for Wireless Local Area Network band applications.
Improvement of the flashover threshold of TUK pressboard by using FeO3‐based nanofluid of monoesters
Authors: Jiosseu Jean Lambert , Mengounou Ghislain Mengata , Tchamdjio Nkouetcha Emeric , Moukengue Imano Adolphe 
Published: November 2023

AbstractThis article deals with the improvement of the dielectric properties of TUK cellulose paper by impregnation. The experiment was carried out using a nanofluid based on vegetable oil esters and iron nanoparticles (FeO3). The insulating liquids used are palm kernel oil methyl ester (PKOME) and castor oil methyl ester (COME). The evaluation of the improvement is based on the analysis of the flashover voltage of the creeping discharges produced on the immersed paper. The tests were carried out under a positive lightning impulse voltage and for two electrode configurations. The concentrations of nanoparticles used in the experiment are 0.10 wt.%, 0.15 wt.% and 0.20 wt.%. The experimental results show that the 0.10 wt.% concentration gives the best improvement for the two electrode configurations used. The improvements are 53% for the inclined tip and 56.90% for the vertical tip in the case of COME + FeO3. For PKOME + FeO3, the results are 59.90% and 64.60%, respectively, for the two configurations.
Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm
Authors: Pang Lei , Ding Zijun , Bian Xiaodong , Shuang Weibing 
Published: November 2023

AbstractWe analyzed the symptoms composition of Interstitial Cystitis (IC), the regularity of the evolution of symptoms before and after treatment, and the visualization of the community network, to provide a reference for clinical diagnosis and treatment of Interstitial Cystitis. Based on the outpatient electronic case data of 552 patients with Interstitial Cystitis, we used a complex network community discovery algorithm, directed weighted complex network, and Sankey map to mine the data of the symptoms composition of Interstitial Cystitis, the evolution of symptoms before and after treatment and the visualization of the community network, to analyze the epidemiological characteristics of interstitial cystitis symptoms in the real world. By the community division of the complex network of interstitial cystitis symptoms, We finally obtained three core symptom communities. Among them, symptom community A (bladder‐related symptoms) is the symptom community with the highest proportion of nodes (60.00%) in the complex network of Interstitial Cystitis, symptom community B (non‐bladder‐related symptoms 1) ranks second (32.00%) in a complex network of Interstitial Cystitis, and symptom community C (non‐bladder‐related symptoms 2) has the lowest proportion (8.00%). There is a complex evolutionary relationship between the symptoms of Interstitial Cystitis before and after treatment. Among the single symptoms before and after treatment, the decreased rate of Day frequency is 93.22%, and the reduced urgency rate is 93.07%. The decline rate of Nocturia was 82.33%. From the perspective of different communities, the overall symptoms of symptom community A decreased by 34.39% after treatment, the general symptoms of symptom community B decreased by 35.37%, and the prevalent symptoms of symptom community C decreased by 71.43%. In the case of using diet regulation treatment to treat bladder pain, the cure rate of bladder pain can reach 22.67%. The cure rate of burning in bladders can get 15.38% with Percutaneous Sacral neuromodulation, 96.95% with diet regulation treatment, and 100% with Percutaneous Sacral neuromodulation. When using behavioral physiotherapy to treat bladder pain, 3.57% of the patient's symptoms change to bladder discomfort; 4% of the patient's symptoms change to bladder discomfort when using oral medicine to treat bladder pain.Symptom research methods based on community findings can effectively explore the rule of symptom outcome of Interstitial Cystitis before and after treatment, and the results are highly interpretable by professionals.The cover image is based on the Original Article Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm by Lei Pang et al., https://doi.org/10.1049/syb2.12083
Genetische Diagnostik und molekulare Ansätze bei pulmonalarterieller Hypertonie
Authors: Eichstaedt Christina A. , Bikou Olympia , Sommer Natascha , Schermuly Ralph T. , Pullamsetti Soni S. , Weissmann Norbert , Harbaum Lars , Tabeling Christoph , Wißmüller Max , Foris Vasile , Kuebler Wolfgang M. , Hinderhofer Katrin , Olschewski Andrea , Kwapiszewska Grazyna 
Published: November 2023

ZusammenfassungDie kürzlich erschienenen, neuen Leitlinien für pulmonale Hypertonie bieten den bisher ausführlichsten Einblick in die genetische Diagnostik und Beratung von PAH-Patient*innen. Aber auch der Stellenwert des klinischen Screenings von gesunden Anlageträger*innen wird hervorgehoben sowie der genetischen Testung bei Patient*innen mit dem Verdacht auf eine pulmonal veno-okklusive Erkrankung. Die jeweiligen Abschnitte der Leitlinien werden im Folgenden in die aktuelle Datenlage eingebettet und kommentiert. Abschließend geben wir einen Ausblick auf neue molekulare Ansätze von Sotatercept über Ionenkanäle bis hin zu neuen therapeutischen Ansatzpunkten.
Chronisch thromboembolische pulmonale Hypertonie (Gruppe 4)
Authors: Guth Stefan , Wilkens Heinrike , Halank Michael , Held Matthias , Hobohm Lukas , Konstantinides Stavros , Omlor Albert , Seyfarth Hans-Jürgen , Schäfers Hans-Joachim , Mayer Eckhard , Wiedenroth Christoph B. 
Published: November 2023

ZusammenfassungDie chronisch thromboembolische Lungengefäßerkrankung (CTEPD) ist eine wichtige Spätfolge der akuten Lungenembolie, bei der die Thromben in fibröses Gewebe transformiert werden, mit der Gefäßwand verwachsen und zu chronischen Obstruktionen führen. Man unterscheidet die CTEPD ohne pulmonale Hypertonie (PH) mit einem pulmonalarteriellen Mitteldruck bis 20 mmHg von der Form mit PH. Hierbei spricht man weiterhin von chronisch thromboembolischer pulmonaler Hypertonie (CTEPH).Liegt der Verdacht auf eine CTEPH vor, sollten initial eine Echokardiografie und eine Ventilations-/Perfusions-Szintigrafie erfolgen, um Perfusionsdefekte nachzuweisen. Danach empfiehlt sich die Zuweisung zu einem CTEPH-Zentrum, wo weitere bildgebende Diagnostik und eine Rechtsherzkatheteruntersuchung erfolgen, um die Diagnose zu sichern und das Therapiekonzept festzulegen.Drei Therapieoptionen stehen aktuell zur Verfügung. Therapie der Wahl ist die pulmonale Endarteriektomie (PEA). Für nichtoperable Patient*innen oder Patient*innen nach PEA und residueller PH, gibt es eine gezielte medikamentöse PH-Therapie sowie das interventionelle Verfahren der pulmonalen Ballonangioplastie (BPA). Zunehmend werden PEA, BPA und die medikamentöse Therapie im Rahmen multimodaler Konzepte kombiniert.Alle Patient*innen müssen nachgesorgt werden, was vorzugsweise in (CTE)PH-Zentren erfolgen sollte. Für CTEPH-Zentren werden eine Mindestanzahl von PEA-Operationen (50/Jahr) und BPA-Interventionen (100/Jahr) gefordert.
Load-velocity Relationship of the Bench Press Exercise is not
Affected by Breast Cancer Surgery and Adjuvant Therapy
Authors: Franco-López Francisco , Pérez-Caballero Carlos , Buendía-Romero Ángel , Borrego Eduardo R. , Martínez-Cava Alejandro , Pallarés Jesús G. , Hernández-Belmonte Alejandro 
Published: November 2023

AbstractWe examined the effect of breast cancer surgery and adjuvant therapy on the
relationship between bar velocity and relative intensity (load-velocity [L-V]
relationship) of the bench press (BP) exercise. Twenty-two breast cancer
survivors (age: 48.0±8.2 yr., relative strength:
0.40±0.08) completed a loading test up to the one-repetition maximum
(1RM) in the BP using a lightweight carbon bar. General and individual
relationships between relative intensity (%1RM) and mean propulsive
velocity (MPV) were studied. Furthermore, the mean test velocity
(MPVTest) and velocity attained to the 1RM (MPV1RM)
were analyzed. These procedures and analyses were also conducted in 22 healthy
women (age: 47.8±7.1 yr., relative strength: 0.41±0.09)
to examine the differences in velocity parameters derived from these L-V
relationships. Polynomial regressions showed very close relationships
(R2≥0.965) and reduced estimation errors
(≤4.9% 1RM) for both groups. Between-group differences in MPV
attained to each %1RM were small
(≤0.01 m·s−1) and not significant
(p≥0.685). Similarly, the MPVTest
(0.59±0.06 m·s−1) and
MPV1RM
(0.17±0.03 m·s−1) were identical
for breast cancer survivors and healthy women. These results suggest that
practitioners could use the same velocity parameters derived from the BP L-V
relationship to prescribe this exercise in middle-aged women, regardless of
whether they have suffered from breast cancer.
Enantioselective (3+2)-Annulation of β-Keto Esters with Azoalkenes towards Bicyclic Dihydropyrroles via Cooperative Palladium and Brønsted Acid Catalysis
Authors: Schneider Christoph , Friedmann Till , Mireles-Chávez Daniel A. , Walter Frederik L. 
Published: November 2023

AbstractA cooperative catalytic process through palladium and Brønsted acid activation is developed for the conjugate addition of cyclic β-keto esters to azoalkenes directly followed by hemiaminal formation upon cyclization. This transformation is enabled by utilizing chiral Pd-aqua complexes as combined Brønsted acid–base catalysts. Thus, bicyclic and highly functionalized dihydropyrroles with two contiguous quaternary stereogenic centers are formed in excellent yields as single diastereomers and with exceptional enantioselectivity.
A Fluorescent Probe for C24 Fatty Acids to Report the Deep Interior of Lipid Bilayers
Authors: Umegawa Yuichi , Murata Michio , Fukunaga Shiho , Yasuda Tomokazu 
Published: November 2023

AbstractTo investigate the interdigitation and the resulting fluctuation of lipid chains in the deep part of biomembranes, we aimed to develop a new fluorescent probe based on the well-known trans-parinaric acid (t-PA), but with a tetraene near the end of the C24 chain. The probe, tetracosa-16,18,20,22-tetraenoic acid (TCTEA), synthesized mainly by means of reported strategies, was found to better reflect the behavior of lipids in the deeper interior of bilayers than did t-PA. TCTEA could serve as a useful probe for studying the plasma-membrane dynamics of very-long-chain fatty acids, which have recently elicited significant attention in relation to necroptosis.
Nonstationary laser-supported ionization wave in layer of porous substance with subcritical density
Authors: Gus’kov S. Yu , Yakhin R. A. 
Published: November 2023

A time-dependent analytical solution is found for the velocity of a plane ionization wave generated under nanosecond laser pulse action on the surface of a flat layer of low-Z porous substance with density less than the critical density of the produced plasma. With corrections for the two-dimensional nature of the problem when a laser beam of finite radius interacts with a flat target, this solution is in quantitative agreement with measurements of ionization wave velocity in various experiments. The solution compared with experimental data covering wide ranges of performance conditions, namely, (3–8) × 1014 W cm−2 for laser pulse intensity, 0.3–3 ns for pulse duration, 0.35–0.53 μm for laser wavelength, 100–1000 μm for laser beam radius, 380–950 μm for layer thickness, 4.5–12 mg cm−3 for average density of porous substance, and 1–25 μm for average pore size. The parameters of the laser beam that ensure the generation of a plane ionization wave in a layer of subcritical porous matter are determined for the problem statements and are found to meet the requirements of practical applications.
Photodissociation dynamics of m- and p-cresol in the S1 state: Interplay between the mode-randomization and H atom tunneling reaction
Authors: Kim Junggil , Kang Minseok , Kim Sang Kyu 
Published: November 2023

The H atom tunneling dissociation dynamics of the S1 state of meta- or para-cresol has been investigated by using the picosecond time-resolved pump-probe spectroscopy in a state-specific manner. The S1 state lifetime (mainly due to the H atom tunneling reaction) is found to be mode-dependent whereas it quickly converges and remains constant as the rapid intramolecular vibrational energy redistribution (IVR) starts to participate in the S1 state relaxation with the increase of the S1 internal energy (Eint). The IVR rate and its change with increasing Eint have been reflected in the parent ion transients taken by tuning the total energy (hνpump + hνprobe) just above the adiabatic ionization threshold (so that the dissipation of the initial mode-character could be monitored as a function of the reaction time), indicating that the mode randomization rate into the S1 isoenergetic manifolds exceeds the tunneling rate quite early in terms of Eint for m-cresol (≤∼1200 cm−1) or p-cresol (≤∼800 cm−1) compared to the case of phenol (≤∼1800 cm−1). Though the H atom tunneling dynamics of phenol (S1) seems to be little influenced by the methyl substitution on the either m- or p-position, the IVR rate has been found to be strongly accelerated due to the sharply-increasing (S1) density of states with increasing Eint due to the pivotal role of the low-frequency CH3 torsional mode.
Extent and patterns
Authors: Sun Jingyun 
Published: November 2023

Abstract
While students’ development of language skills is crucial to their development of interpreting competence, existing literature in interpreter training provides little information on the extent and patterns of student interpreters’ language learning behaviours. This study examined 17 Chinese student interpreters’ language learning behaviours through 741 out-of-class learning diary entries. This study quantified data on the frequency, duration, and breakdown of learning activities and compared the data across different program stages and university levels, revealing that (1) language learning was nearly as important as interpreting learning, (2) students’ efforts on language learning were in line with interpreting courses, and (3) while the majority of language learning sessions were comprehension-based and single-modal, students who progressed further in their education and with more elite educational backgrounds spared a bigger proportion for production-based language learning and multi-modal language learning. The article proposes incorporating corresponding language enhancement modules into interpreter education programs to boost training outcomes.
Choosing effective teaching methods for translation technology classrooms
Authors: Hao Yu , Pym Anthony 
Published: November 2023

Abstract
Although it is generally agreed that translation students need to learn how to use translation technologies, there
would appear to be less agreement on what teaching methods are most appropriate to achieve that end. In our survey of eleven
translation-technology teachers in Australia and New Zealand, we found a significant association between the contents and methods
(p = 0.031). Lecture-based methods are reported as being used to teach background knowledge such as history
and current trends, while hands-on skills can be learned in a variety of student-centred activities that run from task-based
groupwork to large-scale simulated projects. Focus-group discussion indicates not only the distribution of appropriate methods, but
the ways teaching can adjust to different class sizes, becoming more collective or more individual. A case study further indicates
some of the institutional variables that inform the use of one teaching method or another, with particular attention to
heterogeneous student groups.