bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addition of Essential Oil Bioadditives as a Mixture of Biodiesel B35 Fuel on the Performance of Reducing Water content and Particulate Content
Authors: Agumsah Anggi Firdaus , Rusli Meika Syahbana , Setyaningsih Dwi , Agustian Egi , Kurniawan Ade 
Published: December 2023

The use of biodiesel is still experiencing problems due to large amount of water content which produce from the transesterification process, making it has unstable oxidizing properties. The large amount of water content in biodiesel causes the emergence of microorganisms which becoming sludge in the engine room, and can clog the fuel filter. In this study, we propose the application of oxygenate bio-additives to minimize water and particulate content by using turpentine essential oils, clove terpenes, rhodinol, camphor oil, and synthetic additive 2EHN. Based on the study's results, the water content of biodiesel B35 with the AC bio-additive mixture experienced the highest decrease in water content, which was 18% or 287.2 ppm and performs well in reducing particulate levels of 4, 6, and 14 microns. The completely randomized design (CRD) test results for non-factorial moisture content on days 0, 3, 5, 7, and 14 and particulate matter 4, 6, and 14 microns showed no significant difference because each P value was obtained greater than α (0.05). Keywords: Bio-Additives, Biodiesel, Oxidation, Oxygenate, Particulates.
Physicochemical Quality of Oyster Mushroom for Functional Food
Authors: Haris Helmi , Rachmat Ridwan , Fitrilia Tiana , Syarbaini Ahmad , Ma’ruf Amar , Djuanda Dede , Histifarina Dian , Sembiring Bagem 
Published: December 2023

This article presents studies on the physicochemical quality of oyster mushrooms grown within a housing and controlled by the Internet of Things (IoT). The goals of this study were to assess (1) the impact of indoor air quality on the growth and quality of mushrooms and (2) the antioxidant content of oyster mushrooms. In this study, the air temperature and humidity of oyster mushroom house per unit time was recorded and controlled automatically by an IoT system. Additionally, their physicochemical and microbiological quality were evaluated using physico-analytical instruments, and the potency of their ergothioneine (EGT) content was investigated using the HPLC method. The temperature of the air inside was between 29 and 35 °C, and the relative humidity was between 60% and 90%. The average texture of mushroom is soft. The average length, width, and height of the fresh mushroom were 41.5 mm, 60.0 mm, and 29.5 mm, respectively. The microbiological test confirmed that there was no salmonella infection in the collected mushrooms. The button-stage mushrooms have less total fungus than the bloom-stage mushrooms. The extraction standard method employs an EGT content of 0.674 mg/g as determined by chromatography data analysis. The oyster mushrooms can be consumed as a healthy meal, and the study of EGT showed also very prospective as one of immunotherapeutic food. Keywords: Ergothioneine, Fibre-reinforced plastic house, Internet of think, Oyster mushrooms
The Shelf-life, Microbiology Quality, and Characteristic Changes of Probiotic Lactobacillus plantarum Dad-13 Milk Jelly Candy during Storage
Authors: Kamil Rafli Zulfa , Fadhila Fida Hasna , Dea Angela , Rahayu Endang Sutriswati , Hartiningsih Subekti 
Published: December 2023

Probiotics are live microorganisms that, when consumed in sufficient amounts, can provide health benefits to their host. L. plantarum Dad-13 milk jelly candies are non-fermented probiotic products. This study aims to evaluate the changes in the characteristics of probiotic milk jelly candies during storage and their microbiological quality. Characteristics such as pH, water activity (aw), hardness, chewiness, gumminess, brightness, and viability of lactic acid bacteria were analyzed over a period of 4 weeks at two temperatures, namely 4 and 30°C. Sub-lethal injury analysis was conducted to estimate the survival of probiotic cells during the jelly candy manufacturing process. Microbiological quality was assessed through Total Plate Count (TPC), Coliform, Escherichia coli, Salmonella, Mold, and Yeast analyses. The research results showed that the number of probiotic cells experiencing injury was less than 5%. Furthermore, changes in physical characteristics were observed during the 4-week storage period, but the temperature difference only affected pH and aw. The viability of lactic acid bacteria was more stable at a storage temperature of 4°C, and the microbiological quality met the jelly candy standards, except for TPC. Based on the research findings, milk jelly candies can be used as a carrier for probiotic cells as a non-fermented probiotic product innovation, with a recommended storage temperature of 4°C and best consumed within 47 days. Additionally, probiotic milk jelly candies are free from other microbial contamination. Keywords: Jelly candy, L. plantarum Dad-13, Microbiological quality, Probiotic, Storage
Study of Coffee Bean Displacement Inside Drum Roaster Using Force Balance Analysis
Authors: Suud Hasbi Mubarak , Novijanto Noer , Nadzirah Rufiani , Savitri Dyah Ayu 
Published: December 2023

The drum roaster's design and operating method significantly affect the coffee roasting process. The coffee bean displacement inside the drum roaster can be observed to compare the drum roaster's different designs and operating methods. The coffee bean movement is crucial since it affects the heat transfer distribution among coffee beans inside the drum roaster. The more dynamic displacement of coffee beans gives more even heat distribution. Force balance analysis can be used to predict the coffee bean displacement since it can predict particle movement with mutable variables. This paper compares the coffee bean displacement inside the drum roaster with flippers and without flippers using simple force balance analysis. The analysis involves tangential force, centrifugal force, frictional force, and the beans' weight itself. The analysis shows that the radius of the drum roaster (r) and angular acceleration (ω) significantly change the resultant force's dynamic, and the various tilt angle of flippers (β) did not too significantly affect it. The bigger radius (r) and angular acceleration (ω) generate a stronger centrifugal force influencing the bean's equilibrium. The direction change of force resultant applied to the bean is more smooth in the drum with flippers than without flippers. Keywords: Coffee bean displacement, Drum coffee roaster, Force balance analysis, Resultant force Turning point duration
Analisis Faktor-Faktor yang Memengaruhi Adopsi E-commerce oleh UMKM Kerajinan DIY
Authors: Palangan Citra Yayu' 
Published: December 2023

Abstrak. Saat ini penggunaan e-commerce di Indonesia berkembang dengan pesat. Banyak bisnis yang mulai mengadopsi platform e-commerce karena manfaat yang ditawarkan oleh teknologi ini cukup beragam. Meski memiliki kelebihan, banyak Usaha Mikro, Kecil, dan Menengah (UMKM) yang masih lamban dalam mengadopsi teknologi e-commerce. Oleh karena itu, penelitian ini mengusulkan model teoritis untuk memahami faktor-faktor yang mempengaruhi adopsi e-commerce dalam konteks UMKM berdasarkan teori Technology Organizational Environmental (TOE) dan faktor personal dari pemilik UMKM. Temuan penelitian menunjukkan bahwa manfaat yang dirasakan dan dukungan pemerintah mempunyai pengaruh positif terhadap adopsi e-commerce.
Abstract. The use of e-commerce is rapidly growing in Indonesia, and many businesses are adopting this platform due to its benefits. However, despite its advantages, the Micro, Small, and Medium Enterprises (MSMEs) have been slow to adopt this technology. Therefore, this study proposes a theoretical model to understand the factors that influence e-commerce adoption in the MSME context based on the Technology Organizational Environmental (TOE) model and individual factors. The research findings indicate that perceived benefits and government support have a positive influence on e-commerce adoption.
Musik dalam Disiplin Ilmu Islam: Fenomena Remix Lagu Religi dengan Alunan Musik DJ
Authors: Ayumi Rahma Arindani , Susan Eri , Hartiyani Suci , Ramadhani Rahmatunnisa , Gartiani Prili Dwi , Kusnadi Kesya Arla , Supriadi H Udin , Parhan Muhamad 
Published: December 2023

Ilmu dan pengetahuan merupakan hal yang tidak dapat dipisahkan di dalam kehidupan manusia karena hal tersebut sangat memberikan manfaat baik. Manusia yang dibekali Allah SWT memiliki akal dan pikiran agar mereka bisa mendapatkan ilmu dan pengetahuan yang baik dan benar. Meskipun demikian selayaknya ilmu pengetahuan tidak terlepas dari ajaran agama dan dipisahkan dari ilmu agama itu sendiri. Islam adalah agama yang menjunjung ilmu pengetahuan dan begitu juga Ilmu pengetahuan memiliki interaksi dengan agama. Kemajuan zaman, teknologi dan arus informasi seakan memperlebar jarak antara ilmu pengetahuan dan agama. Namun, sering kali mereka keliru dan tidak menggunakan akal pikirannya untuk memilah serta memilih hal baik dan hal buruk untuk kehidupan mereka. Mereka bebas menuangkan pikiran dan berkreasi dengan hal yang menurut mereka menyenangkan tanpa memperhatikan suatu kedisiplinan ilmu dan hal tersebut adalah buruk. Karena di zaman sekarang sedang tren yaitu musik DJ yang mana alunannya enak di dengar bagi manusia dan sering kali terdengar bahwa lagu religi di Remix dengan alunan musik DJ maka dari itu hasil dan pembahasan memaparkan bahwa Fenomena Remix lagu religi dengan alunan musik DJ .
Analisis Komposisi Original Soundtrack (Ost) Huta Namartuai dalam Film Ngeri-Ngeri Sedap
Authors: Panggabean Ance Juliet , Simangunsong Emmi 
Published: December 2023

Lagu Huta Namartuai diciptakan khusus untuk soundtrack/OST Film Ngeri-ngeri Sedap dan tujuan tertentu dalam hal Hahomion Batak (memahami makna secara mendalam) dan Pariwisata Toba. Tujuan penelitian ini untuk memahami pengolahan elemen musik dan konstruksi komposisi mulai dari intro, verse, refrain dan ending lagu Huta namartuai dalam Film Ngeri Ngeri Sedap. Metode dasar yang diterapkan di dalam penelitian ini adalah metode deskriptif kualitatif. Hasil penelitian elemen musik yang dianalisa terdiri atas melodi, ritme dan harmoni. aspek melodi yang dianalisa pada lagu ini mencakup: durasi, pitch, dan tone. Pengolahan elemen ritme tersusun atas elemen ketukan, aksen, sinkopasi, tanda birama, meter, tempo. Pengolahan elemen harmoni dilakukan mencakup aspek berhubungan dengan keselarasan bunyi. Unsur ini meliputi peranan, susunan, dan hubungan dari sebuah paduan bunyi dengan bentuk secara keseluruhan serta elemen interval dan akor. Dasar-dasar konstruksi dalam komposisi musik secara umum, terdiri atas permulaan/ beginning/ pengantar/intro, kelanjutan/continuation, komplikasi/complication, dan resolusi/resolution. Untuk beat dan ambience lagu menonjolkan tekstur, nada, suasana hati, Huta Namartuai dirancang untuk menimbulkan ketenangan, dan sasaran lagu lingkungan masa kecil kita yang menjadi tempat perlindungan. Peranan Instrumen pada lagu Huta Namartuai, Drum piano, Gitar Rythmn, Gitar Lead (instrument modern/instrumen barat), 2. Pad Basic, Pad high, Backing Vocal Unison (subconscious ambience feeling/perasaan suasana bawah sadar), 3. Sulim (sebagai sipakuling tondi/memanggil jiwa dan identitas Batak)/salah satu alat musik tradisional Batak Toba.
Complex Regional Unification of Private International Law Rules on the Base of a Three-Part Structure: Political and Legal Framework
Authors: BERMAN Alisa , ERSHOV Nikita 
Published: December 2023

This article examines the theoretical and legal framework of a complex regional unification of private international law rules on the basis of a three-part structure. The authors analyzed reasons for spread of trends to regional unification of private international law. Special attention in the article is given to the definition of the content and essence of a complex regional unification. The authors define acts of complex unification as acts structured according to the principle of a consistent response to the questions of applicable law, jurisdiction, recognition and enforcement of foreign decisions in the regulated area. The article identifies the key advantages and disadvantages of a complex unification of private international law based on a three-part structure. The authors conclude that, to date, the adoption of acts of complex unification based on the three-part structure is one of the key trends in the unification of private international law.
Synthesis, antiproliferative and antiplasmodial evaluation of new chloroquine and mefloquine-based harmiquins
Authors: Pavić Kristina , Poje Goran , Carvalho Lais Pessanha De , Held Jana , Rajić Zrinka 
Published: December 2023

Abstract
Here we present the synthesis and evaluation of the biological activity of new hybrid compounds, ureido-type (UT) harmiquins, based on chloroquine (CQ) or mefloquine (MQ) scaffolds and β-carboline alkaloid harmine against cancer cell lines and Plasmodium falciparum. The hybrids were prepared from the corresponding amines by 1,1′-carbonyldiimidazole (CDI)-mediated synthesis. In vitro evaluation of the biological activity of the title compounds revealed two hit compounds. Testing of the antiproliferative activity of the new UT harmiquins, and previously prepared triazole-(TT) and amide-type (AT) CQ-based harmiquins, against a panel of human cell lines, revealed TT harmiquine 16 as the most promising compound, as it showed pronounced and selective activity against the tumor cell line HepG2 (IC
50 = 5.48 ± 3.35 μmol L−1). Screening of the antiplasmodial activities of UT harmiquins against erythrocytic stages of the Plasmodium life cycle identified CQ-based UT harmiquine 12 as a novel antiplasmodial hit because it displayed low IC
50 values in the submicromolar range against CQ-sensitive and resistant strains (IC
50 0.06 ± 0.01, and 0.19 ± 0.02 μmol L−1, respectively), and exhibited high selectivity against Plasmodium, compared to mammalian cells (SI = 92).
Mendeleev’s discovery of the periodic table and the first European Academy of Sciences to honour him
Authors: Flegar Vanja Horvat , Inić Suzana 
Published: December 2023

Abstract
The chemical science community will commemorate the 155th anniversary of Mendeleev’s groundbreaking discovery of the periodic table of elements in 2024. This paper aims to underscore the significance of Mendeleev’s honorary membership in the Academy of Sciences in Zagreb, Croatia, which occurred in 1882, making it the first scientific academy in Europe to extend this recognition. Additionally, we seek to explore the contextual circumstances that contributed to this noteworthy event within the broader European context. To provide insight into the specificities and variations in the influence and reception of the periodic table of elements within the educational process of select European countries (Russia, Germany, Czech Lands, Serbia), we conducted a comprehensive review, drawing comparisons to Croatia. Notably, upon its initial publication in 1869, the discovery of the periodic table did not gain immediate acceptance in Croatia, largely attributed to the absence of a well-established presence of chemical science within the country. About fifteen years passed from Mendeleev’s discovery of the periodic law to its reception and dissemination throughout Croatia. Despite an initial delay, Croatian chemical science followed the development of the periodic table through secondary and university education, while actively partaking it in.
Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections
Authors: Rukavina Zora , Jøraholmen May Wenche , Božić Dunja , Frankol Ivana , Gašparović Petra Golja , Škalko-Basnet Nataša , Klarić Maja Šegvić , Vanić Željka 
Published: December 2023

Abstract
Azithromycin (AZT) encapsulated into various types of liposomes (AZT-liposomes) displayed pronounced in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) (1). The present study represents a follow-up to this previous work, attempting to further explore the anti-MRSA potential of AZT-liposomes when incorporated into chitosan hydrogel (CHG). Incorporation of AZT-liposomes into CHG (liposomal CHGs) was intended to ensure proper viscosity and texture properties of the formulation, modification of antibiotic release, and enhanced antibacterial activity, aiming to upgrade the therapeutical potential of AZT-liposomes in localized treatment of MRSA-related skin infections. Four different liposomal CHGs were evaluated and compared on the grounds of antibacterial activity against MRSA, AZT release profiles, cytotoxicity, as well as texture, and rheological properties. To our knowledge, this study is the first to investigate the potential of liposomal CHGs for the topical localized treatment of MRSA-related skin infections. CHG ensured proper viscoelastic and texture properties to achieve prolonged retention and prolonged release of AZT at the application site, which resulted in a boosted anti-MRSA effect of the entrapped AZT-liposomes. With respect to anti-MRSA activity and biocompatibility, formulation CATL-CHG (cationic liposomes in CHG) is considered to be the most promising formulation for the treatment of MRSA-related skin infections.
Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia
Authors: Okroša Ana Dugonjić , Silovski Tajana , Plavetić Natalija Dedić , Silovski Hrvoje , Kovačić Ana , Mucalo Iva 
Published: December 2023

Abstract
This observational, cross-sectional study conducted at the University Hospital Centre Zagreb (UHC Zagreb) aimed to explore patients’ beliefs about adjuvant endocrine therapy (AET) as well as their association with non-adherence and sociodemographic and clinical factors. Out of 420 early breast cancer (BC) patients included in the study, 79.5 % perceived AET necessary and important for their health, as measured by the Belief About Medicines Questionnaire (BMQ), with the mean necessity score (20.4 ± 3.68) significantly higher than the mean concerns score (13 ± 4.81) (p < 0.001). Based on the Medication Adherence Report Scale (MARS-5), 44.4 % (n = 182) of the participants were non-adherers, out of which 63.2 % (n = 115) were unintentional and 36.8 % (n = 67) intentional non-adherers. Significantly higher concern beliefs were found among patients that were younger (p < 0.001), employed (p < 0.001), intentionally non-adherent to AET (p = 0.006), had a lower body-mass index (p = 0.005) and a higher level of education (p < 0.001), were premenopausal at the time of diagnosis (p < 0.001), taking tamoxifen treatment (p = 0.05) and receiving ovarian suppression (p < 0.001). Younger patients should be recognized as being at risk of non-adherence as they hold greater concern beliefs about medicines.
Prescribers’ approval rate of pharmacist-initiated interventions to optimise patients’ clinical status of hypertension in the ambulatory care setting
Authors: Brajković Andrea , Bićanić Lucija Ana , Orehovački Helena , Prkačin Ingrid , Oliveira Djenane Ramalho De , Mucalo Iva 
Published: December 2023

Abstract
This perspective, pre- and post-intervention study with a one-year follow-up primarily aimed to ascertain prescribers’ approval rate of pharmacists’ interventions and clinical status of hypertension following comprehensive medication management (CMM) intervention in the ambulatory care clinic. Between January 2018 and January 2022 overall 100 patients with hypertension and other comorbidities were referred to the CMM services at the Health Centre Zagreb – Centar (HCZC). Out of 275 interventions directed to prescribers, 73.1 % of interventions were approved, 12.4 % were rejected and 14.5 % were not reviewed. The percentage of patients with a blood pressure goal increased from 45 % at the initial consultation to 82.5 % at the patients’ latest encounter (p < 0.001). The average number of drug therapy problems (DTPs) per patient totaled 3.53 ± 1.80, where 98 % of patients had one or more DTPs, 48 % had 4 or more DTPs, whereas 26 % had 5 or more DTPs. Sub-therapeutic dosage (32.6 %) and the need for additional drug therapy (30.9 %) were the two most commonly identified DTPs. These results reinforce the need to integrate pharmacy-led services in the primary care setting with the aim of improving patients’ health outcomes.
Recent findings and advancements in the detection of designer benzodiazepines: a brief review
Authors: Wu Dihua , Fu Li 
Published: December 2023

Abstract
This review article takes a closer look at a new class of psychoactive substances called designer benzodiazepines (DBZs) and the challenges of their detection. These are adinazolam, clonazolam, deschloroetizolam, diclazepam, etizolam, flualprazolam, flubromazepam, flubromazolam, phenazepam, and pyrazolam. They are central nervous system depressants and sedatives that can cause psychomotor impairment and increase the overdose risk when combined with other sedatives. DBZs undergo phase I and II metabolism similar to traditional benzodiazepines, but their specific metabolic pathways and the influence of genetic polymorphisms are yet to be clarified. Advances in liquid chromatography-tandem mass spectrometry (LC-MS/MS) have enhanced the method's sensitivity for DBZs and their metabolites in biological samples and coupled with improved blood sampling methods require less blood for drug monitoring. Further research should focus on elucidating their pharmacokinetic properties and metabolism in humans, especially in view of genetic polymorphisms and drug interactions that could inform clinical treatment choices. Even though we have witnessed important advances in DBZ detection and measurement, further refinements are needed to expand the scope of detectable DBZs and their metabolites. All this should help toxicological research to better identify and characterise the risks of chronic and polydrug abuse and facilitate clinical, forensic, and regulatory responses to this growing issue.
Mortality, cancer incidence, and disability among professional drivers in Slovenia
Authors: Margan Andrea , Fikfak Metoda Dodič 
Published: December 2023

Abstract
Literature data about all-cause and cause-specific mortality among professional drivers are inconsistent. Most studies report lower all-cause and higher cause-specific mortality. Higher cause-specific mortality is most often the result of malignant and circulatory diseases. The aim of our retrospective cohort study was to get a better insight into the mortality, cancer incidence, and occupational disability of the entire professional driver population in Slovenia (N=8,231) from 1997 to 2016 through standardised mortality ratio (SMR), standardised proportional mortality ratio (SPMR), standardised cancer incidence ratio (SIR), and standardised disability ratio (SDR). Total mortality was significantly lower than that of the general working population (SMR=0.49; 95 % CI=0.44–0.55). When SPMR was calculated, however, the risk of all-cause mortality increased to 1 (SPMR=1.00; 95 % CI=0.89–1.12), of cancer-related mortality to 1.13 (95 % CI=0.94–1.35), and of injury-related mortality to 1.25 (95 % CI=0.97–1.59). Cancer incidence was lower than in the general male working population for all types of cancer (SIR=0.66; 95 % CI=0.59–0.72), lung cancer included (SIR=0.56; 95 % CI=0.41–0.73). Occupational all-cause and cause-specific disability were also lower than in the rest of the working population. Even though all types of cancer and injuries were established among professional drivers in Slovenia, no major risk stand out. However, our findings may have been skewed by the healthy worker effect.