bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urodynamic Findings of The Patients with Parkinson’s Disease: A Single Tertiary Center Results
Authors: ŞAHİN Mehmet Fatih , AKGÜL Murat , DOĞAN Çağrı , MALAK Arzu , ŞERAMET Serkan , YAZICI Cenk Murat 
Published: February 2024

Objective :In Parkinson’s disease (PD), lower urinary tract symptoms (LUTS) are common with a prevalence ranging from 25% to 57%. Patients who are resistant to medical treatment for LUTS may require urodynamic examination and pressure flow study (UD-PFS) to better comprehend the bladder's dynamics. To be able to comprehend the pathophysiology of LUTS, UD-PFS examinations should be performed. In this study, the demographics and clinical properties of PD patients were presented along with their UD-PFS examinations.
Method : The data of 155 patients with PD followed up between 2010-2020 were retrospectively analyzed. UD-PFS was applied to 42 PD patients resistant to medical treatment of LUTS. Patients' demographic and clinical data with their UD-PFS findings were studied separately.
Result : Twenty-eight of the patients underwent UD-PFS were male, and 14 were female. In UD, the first urinary sensation was 86.00±68.77cc, and the maximum cystometric capacity was 322.07±194.25cc. Sixteen patients had a hypo-compliant bladder, 25 (59.5%) had a normo-compliant bladder. In PFS, Q max and peak detrusor pressure during voiding were 12.72±10.08 mL/sec and 43.93±15.56 cm-H2O, respectively. Stress-type urinary incontinence was detected in 6 (15%) of the patients. When evaluating the detrusor activity, neurogenic detrusor overactivity in 18 (44%) patients, detrusor areflexia in 8 (19%) and normal UD-PFS in 16 (22%) patients.
Conclusion: The majority of the patients presented with neurogenic detrusor overactivity accompanied by diminished bladder capacity and hypersensitivity. In the selected PD patients who are resistant to medical treatment with LUTS clinics, UD-PFS provides useful scientific information about the LUTS clinics of patients and may be helpful in treatment management.
The Correlation between the Bone Morphotype and Density and Root Apical Resorption of the Anterior Teeth Due to Orthodontic Forces
Authors: Tsilosani Nino , Natsvlishvili Natia , Mirvelashvili Ekaterine , Zerekidze Tea 
Published: February 2024

The potential side effects of modern orthodontic treatment and its unfavorable impact on dentition and hard tissues have been extensively discussed in professional literature for decades. The presence of uncontrolled forces can result in pulp necrosis, radicular reabsorption, and/or loss of alveolar bone. Dehiscence and fenestration are more commonly found in anterior than posterior teeth, where only the periodontal ligament and the mucosa protect the dental root.
Most studies investigating the effect of periodontal phenotype over gingival recession in orthodontic patients have primarily focused on examining the soft tissues. However, due to the vulnerability of thin alveolar bone, the previous evaluation of orthodontic candidate patients may also include the analysis of hard tissues. Bone density plays an important role in facilitating orthodontic tooth movement, such that reductions in bone density can significantly increase movement velocity. These types of localized density changes can affect the rate of orthodontic tooth movement and may also influence the risk of unwanted outcomes, such as the occurrence of dental external apical root resorption.
According to the literature, the links of root resorption with the bone morphotype and the density are relevant in clinical dentistry but have not been studied in detail. However, the existing data is not yet conclusive.
Virtual Collaborative Learning as One of the Effective Strategies for Raising Cross-Cultural Awareness in Business English Classroom
Authors: Dolidze Tamari , Mikeladze Nino , Abesadze Anna , Mansfield Michael Jack 
Published: February 2024

Recently, Business English (BE) has become an integral part of teaching English due to its growing demand in the employment market and its power to facilitate cross-cultural communication and dialogue between speakers of all languages. Since BE serves as a Lingua Franca globally, a good mastery of the so-called Business English as Lingua Franca (BELF) is getting more and more attention among practitioners and researchers of Business English, who attempt to update their curriculum by cutting-edge developments for better occupational purposes.
With this in mind, the presented paper will attempt to showcase the merits of Virtual Collaborative Learning (VCL) as one of the effective strategic tools for raising cross-cultural communication in the Business English classroom which indeed fosters the development of a culturally intelligent generation through support and guidance.
To assess effectiveness, a survey was conducted among students enrolled in the Business English course offered through virtual learning at Grigol Robakidze University and Azerbaijan Pedagogical University during the Spring 2021 semester. The survey included seven closed prompts using the Likert scale, ranging from "Strongly Agree" to "Strongly Disagree" and "Always" to "Never," and one open-ended question requiring a written response based on personal opinions.
The responses verified the positive influence of VCL activities in promoting interaction among students from different cultures and heightened awareness of cultural understanding. The discovered insights will be integrated into the current curriculum at Grigol Robakidze University, which is scheduled for the upcoming academic year.
Counseling Group and Games Education in Developing English Language for Students’ Elementary School
Authors: Suhono Suhono 
Published: February 2024

The Article analyzed Counseling Group and Games Education in Developing English Language for Students in elementary school. The researcher used the steps for a literature review to obtain scientific evidence (Snyder, 2019; Peters et al., 2020), that is, of counseling groups and games education in developing the English language for students in elementary school. Hence, the researchers have visited several scientific publications on several applications, for instance, Eric Publications, Google Book, Taylor, and France, and many others. In comparison, the review process involves several stages. First, giving coded the data, evaluated and looked for relevance, and interpreted it in depth to conclude if the findings were relevant in answering valid questions. Based on the review, many kinds of publications showed that Innovative games could be in the form of educational games. Educational games are created using computer technology by taking into account the peculiarities, language development, and theories of acquiring children's language so that children are not easily bored in recognizing or learning English vocabulary. Therefore, English educational games can be used to develop English vocabulary.
Pengembangan Media Video Animasi Tentang Pemahaman Kepemimpinan Siswa
Authors: Khoirunnisa Wakhidatul , Nurgraha Ariadi 
Published: February 2024

Students are the next generation of young people who need to be given an understanding of leadership in order to have an attitude of responsibility and be able to contribute in responding to future challenges. Through the services provided by BK teachers, the school becomes a forum for education and the formation of students' personalities and mentality. This study aims to develop animated video media about leadership as an effort to provide information about leadership to students at MTs Negeri 1 Yogyakarta. The research model used in this study adopts the Dick and Carry development model with the term ADDIE, which is a development model consisting of five stages including Analysis, Design, Development , Implementation, and Evaluation. The subjects in this study were 20 students who attended the student council at MTs Negeri 1 Yogyakarta. The results of the animated video media development research on leadership understanding based on the results of the Material Expert assessment, Media Expert assessment, and Service Expert assessment, all received the "very good" category by getting a material validation score of 88.8, Media Validation 83.9 , and Service Validation 94.4. The hope of research on the development of animated video media about understanding leadership can be an alternative for students in getting leadership education that can be a good leadership development.
Involvement of family caregivers in dementia care research: a scoping review protocol
Authors: Jagoda Franziska Anushi , Hirt Julian , Mueller Claudia , Halek Margareta 
Published: February 2024

Abstract

Background
Family caregivers of people with dementia are a distinct group due to the particularly stressful and time-intensive care situation at home. Despite these challenges, involving them in research is crucial to better understand and address their specific needs. However, little evidence exists regarding a tailored approach for researchers for this group considering their situation at home.
Methods
A scoping review will be conducted following the Joanna Briggs Institute methodological guidance, including the databases MEDLINE (PubMed), CINAHL, Scopus (Elsevier) and PsycInfo (EBSCO). The review will include family caregivers of people with dementia, regardless of age, gender, or ethnicity, who have been actively involved in research throughout the research process. Moreover, sources of evidence from any country in both English and German are eligible for inclusion. Sources will be screened by two independent reviewers. Results will be extracted using a tailored charting tool and presented in the final report according to the research questions and objectives.
Discussion
Developing a tailored approach to involve family caregivers of people with dementia in research and development has profound importance to both the scientific community and the target group itself.
Statistical Considerations for the Platform Trial in COVID-19 Vaccine Priming and Boosting
Authors: Dymock Michael , McLeod Charlie , Richmond Peter , Snelling Tom , Marsh Julie A 
Published: February 2024

Abstract

The Platform trial In COVID-19 priming and BOOsting (PICOBOO) is a multi-site, adaptive platform trial designed to generate evidence of the immunogenicity, reactogenicity, and cross-protection of different booster vaccination strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, specific for the Australian context. The PICOBOO trial randomises participants to receive one of three COVID-19 booster vaccine brands (Pfizer, Moderna, Novavax) available for use in Australia, where the vaccine brand subtypes vary over time according to the national vaccine roll out strategy, and employs a Bayesian hierarchical modelling approach to efficiently borrow information across consecutive booster doses, age groups and vaccine brand subtypes. Here, we briefly describe the PICOBOO trial structure, and report the statistical considerations for the estimands, statistical models and decision making for trial adaptations. This paper should be read in conjunction with the PICOBOO Core Protocol and PICOBOO Sub-Study Protocol 1: Booster Vaccination. PICOBOO was registered on 10 February 2022 with the Australian and New Zealand Clinical Trials Registry ACTRN12622000238774.
S-nitrosylation of p39 promotes its degradation and contributes to synaptic spine loss induced by β-amyloid peptide
Authors: Zhang Peng , Cheng Aobing , Wang Jingyi , Li Jiayi , Wang Jie , Xu Mufan , Chen hongzhuan 
Published: February 2024

Abstract

Alzheimer's disease (AD), characterized by cognitive decline, is increasingly recognized as a disorder marked by synaptic loss and dysfunction. Despite this understanding, the underlying pathophysiological mechanisms contributing to synaptic impairment remain largely unknown. In this study, we elucidate a previously undiscovered signaling pathway wherein the S-nitrosylation of the Cdk5 activator p39, a post-translational modification involving the addition of nitric oxide to protein cysteine residues, plays a crucial role in synaptic dysfunctions associated with AD. Our investigation reveals heightened p39 S-nitrosylation in the brain of an amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mouse model of AD. Additionally, soluble amyloid-β oligomers (Aβ), implicated in synaptic loss in AD, induce p39 S-nitrosylation in cultured neurons. Notably, we uncover that the regulation of p39 levels is influenced by S-nitrosylation, with nitric oxide S-nitrosylating p39 at Cys265 and subsequently promoting its degradation. Furthermore, our study demonstrates that S-nitrosylation of p39 at Cys265 significantly contributes to amyloid-β (Aβ) peptide-induced dendrite retraction and spine loss. Collectively, our findings highlight S-nitrosylation of p39 as a novel aberrant redox protein modification involved in the pathogenesis of AD, suggesting its potential as a therapeutic target for the disease.
Antioxidant Activity and Physicochemical Stability of Nanospheres: Evaluation in Vitro and Applied to Biodiesel
Authors: Hagemann Eduarda Carolina Scherer , de Oliveira Karen Cristine Silva , Rodrigues Paulo Rogério Pinto , Lima Fernanda Oliveira , Benvegnú Dalila Moter , CabreiraSoares Letiére , Gallina André Lazarin 
Published: February 2024

Abstract
Biodiesel is a fuel from renewable sources which has several environmental advantages. However, due to structural characteristics, it becomes susceptible to oxidation, requiring the use of antioxidants. In this way, antioxidants added to biodiesel could be degraded when exposed to environmental conditions, reducing their capacity. Therefore, carrier systems, such as nanospheres, are an alternative to providing protection and controlled release of antioxidants. In this work, poly-ε-caprolactone nanospheres containing tert-butyl-hydroquinone and ascorbic acid antioxidants were developed, and their physical-chemical stability and in vitro antioxidant activity were evaluated for 150 days. The nanospheres to biodiesel were also carried out to evaluate the antioxidant activity. Nanospheres with negative zeta potential, polydispersion index less than 0.3, and nanometric scale were obtained. Regarding the in vitro antioxidant activity, the ascorbic acid nanospheres showed results greater than 50%, while for the tert-butyl-hydroquinone nanospheres, the results were greater than 80% during 150 days. The addition of nanospheres containing antioxidants to biodiesel did not present satisfactory results, since it reduced oxidation stability of biodiesel.
Evaluation on Characteristics of Anticancer and Antimicrobial Activities with Cipla Loaded ZnO Nanostructural Rods for Human Breast Cancer Cell Line Targeting
Authors: T Manikandan , G Padmalaya , S Murugeswari , M Ramakrishnan , Krishnasamy Karthik , Mallik Saurav , Tomar Namrata , Shah Mohd Asif 
Published: February 2024

Abstract
A ciprofloxacin-ZnO nanoparticle-based formulation for biocompatible nanodrug delivery has been developed and validated on breast cancer cells. The ciprofloxacin medication was combined with the generated znO nanoparticles utilising a simple chemical process. The structural and morphological study has been revealed using Scanning Electron Microscopy (FESEM) analysis. The crystallinity behaviour of ZnO nanoparticles has been reported previously, which helps to suggest for further biological applications. To enhance the structural study, ciprofloxacin loaded ZnO nanoparticles was revealed to have flower like structure. Their structural analysis was subsequently investigated utilising FESEM after the medication was loaded. From the biological study, ciprofloxacin – ZnO NPs showed excellent cytotoxicity behaviour in MCF-7 cell line which was found from confocal microscopy images using Methylthiazolyl Diphenyl-Tetrazolium Bromide (MTT) assay technique. Antibacterial research also provided support for their other biological functions. A remarkable drug delivery approach for breast cancer therapy may be possibly given by ZnO NPs' suggesting drug loading capacity aids in prolonged release, predominant cancer cell uptake, effective cytotoxicity and better biological profile.
SARS-CoV-2 infection among liver and kidney transplantation recipients in Shiraz, Iran
Authors: Maleki Ali , Yaghobi Ramin , Daneshfar Negar , Golshan Mehdi , Geramizadeh Bita , Amiri Fahimeh Bagheri , Sanati Parastoo Yektay , Rezaie Jahangir , Salehi-Vaziri Mostafa 
Published: February 2024

Abstract
Background; The vulnerability of immunosuppressed populations, including transplant recipients, to infectious diseases has been brought to light once more by the COVID-19 pandemic. The purpose of this study was to look into any possible relationships between COVID-19 and post-transplantation results in liver and kidney transplant recipients.
Material and methods; Individuals who had undergone liver and kidney transplants and tested positive for COVID-19 underwent a retrospective review of their medical records. Patient demographics, transplant characteristics, immunosuppressive therapy, and COVID-19 results were all recorded. Then, nasopharyngeal swab samples were utilized for the whole genome sequencing on the Nanopore NGS platform. Logistic regression analysis was used to evaluate the association among transplant-related Immunosuppression, biological biomarkers, and COVID-19 susceptibility.
Results; The study found a potential correlation between COVID-19 and adverse post-transplantation outcomes in liver and kidney transplant patients. Higher D-dimer in liver transplant patients was seen (p = 0.003). There was also significant rise in RBC (p=0.047), Hb (p=0.027), and Htc (p=0.008) after transplantation.
Discussion and conclusion; The present study provides valuable insights into the potential correlation between COVID-19 and post-transplantation outcomes in liver and kidney transplant patients. The management of transplant recipients during the COVID-19 pandemic would benefit from the current study's findings.
Exploring Deep Learning Strategies for Intervertebral Disc Herniation Detection on Veterinary MRI
Authors: Huang Shoujin , Deng Guoxiong , Kang Yan , Li Jianzhong , Li Jingyu , Lyu Mengye 
Published: February 2024

Abstract

Intervertebral Disc Herniation (IVDH) is a common spinal disease in dogs, significantly impacting their health, mobility, and overall well-being. This study initiates an effort to automate the detection and localization of IVDH lesions in veterinary MRI scans, utilizing advanced artificial intelligence (AI) methods. A comprehensive canine IVDH dataset, comprising T2-weighted sagittal MRI images from 213 pet dogs of various breeds, ages, and sizes, was compiled and utilized to train and test the IVDH detection models. The experimental results showed that traditional two-stage detection models reliably outperformed one-stage models, including the recent You Only Look Once X (YOLOX) detector. In terms of methodology, this study introduced a novel spinal localization module, successfully integrated into different object detection models to enhance IVDH detection, achieving an average precision (AP) of up to 75.32%. Additionally, transfer learning was explored to adapt the IVDH detection model for a smaller feline dataset. Overall, this study provides insights into advancing AI for veterinary care, identifying challenges and exploring potential strategies for future development in veterinary radiology.
Real-Time Contrast-Enhanced Ultrasound Combined with Ultrasound Monitoring Radiofrequency Ablation Versus Laparoscopic Partial Nephrectomy for cT1a Renal Cell Carcinoma: A Comparative Study with Mid-Term Follow-Up
Authors: Chen Shuaiqi , Fan Huijun , Sun Guangyu , Zhu Feng , Li Ran , Liu Ranlu 
Published: February 2024

Abstract

Objective
The study aims to compare oncological and functional mid-term outcomes following real-time contrast-enhanced ultrasound combined with ultrasound monitoring radiofrequency ablation (CEUS/USM-RFA) versus laparoscopic partial nephrectomy (LPN) for treating cT1a renal cell carcinoma (RCC).
Methods
This is a retrospective data analysis of a high-volume single tertiary center. Patients with cT1a RCC were treated with CEUS/USM-RFA or LPN following multidisciplinary decision-making. According to different surgical methods, patients were divided into the RFA and LPN groups. Demographic information, tumor characteristics, surgical data, complications, and functional and oncological outcomes were reviewed. Differences between categorical and continuous parameters were evaluated using Pearson's chi-square and Student's t-tests, respectively.
Results
According to different surgical methods, 164 patients were divided into the RFA (41 cases) and LPN (123 cases) groups. The results revealed a nonsignificant difference in gender, tumor side, tumor size, RCC type, R.E.N.A.L. score, major complications, technical success, technique efficacy, or local tumor progression (LTP) between the two groups (p > 0.05). However, significant differences were observed in age, Eastern Cooperative Oncology Group (ECOG) score, Charlson Comorbidity Index (CCI) score, American Society of Anesthesiologist (ASA) score, tumor location, and minor complications (p < 0.05). The operative time, estimated blood loss, hospitalization time, and estimated glomerular filtration rate (eGFR) loss of the affected kidney in the RFA group were less than in the LPN group (p < 0.05). The decline of post-procedure eGFR of the affected kidney at six months was significantly less in RFA than in the LPN group (1.39 ± 4.67 vs. 4.32 ± 4.00 mL/min/1.73 m2, p < 0.001). Nevertheless, both groups had a similar 2-year recurrence-free survival (RFS) rate (97.65% vs. 100%, p = 0.083).
Conclusion
The CEUS/USM-RFA and LPN for cT1a RCC were all safe and effective. In rigorously screened patients with cT1a RCC, CEUS/USM-RFA had comparable oncological outcomes with LPN. The CEUS/USM-RFA had superiority in perioperative outcomes and preserving renal function.
Examining the Potential of Natural Disaster Monuments as Surrogate Indicators for Disaster Hazards in Japan
Authors: Sakamoto Jun 
Published: February 2024

Abstract

Japan is prone to natural disasters because of its diverse topographical, geological, and climatic conditions. It is vital to gain a deeper understanding of disaster-prevention measures to mitigate these effects. One aspect of this understanding is the construction of natural disaster monuments to educate future generations about lessons learned from past disasters. This study focuses on the location and distribution of these monuments and examines their potential as surrogate indicators of disaster hazards. To achieve this, we employ a two-pronged approach. The first approach is to analyze the relationship between the location of disaster monuments and disaster hazards. It involves plotting the locations of monuments from a database and investigating the relationship between the disaster covered by each monument and the current hazard using a hazard map portal site. The second approach is to assess the potential for disaster hazard mapping based on the disaster monuments. It involves creating Voronoi maps based on the location of disaster monuments and applying them to the entire national land area. It produced a disaster hazard map for Japan, including areas with no disaster monuments. The results provide aggregate information on the relationship between the location of disaster monuments and disaster hazards and the effectiveness of the Voronoi diagram-based disaster hazard maps. In many cases, the current hazard at the location of disaster monuments still exists, and 70% of the areas around tsunami-related monuments are still exposed to tsunami hazards. Additionally, this study suggests that Voronoi maps are promising for disasters and can accurately represent specific disaster hazard areas.