bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk indicators for gingival recession in the esthetic zone: A cross‐sectional clinical, tomographic, and ultrasonographic study
Authors: Mascardo Kathleen Chloe , Tomack Justin , Chen Chia‐Yu , Mancini Leonardo , Kim David M. , Friedland Bernard , Barootchi Shayan , Tavelli Lorenzo 
Published: January 2024

AbstractBackgroundTo evaluate the risk indicators associated with midfacial gingival recessions (GR) in the natural dentition esthetic regions.MethodsCone‐beam computed tomography (CBCT) results of thirty‐seven subjects presenting with 268 eligible teeth were included in the cross‐sectional study. Clinical measurements included presence/absence of midfacial GR; the depth of the midfacial, mesial, and distal gingival recession; the recession type (RT); keratinized tissue width (KT); and attached gingiva width (AG). Questionnaires were utilized to capture patient‐reported esthetics and dental hypersensitivity for each study tooth. Buccal bone dehiscence (cBBD) and buccal bone thickness (cBBT) were measured on the CBCT scans. High‐frequency ultrasonography was performed to assess gingival thickness (GT) and buccal bone dehiscence (uBBD). Intraoral optical scanning was obtained to quantify the buccolingual position of each study site (3D profile analysis). Multilevel logistic regression analyses with generalized estimation equations were performed to assess the factors associated with the conditions of interest.ResultsThe presence of midfacial GR was significantly associated with the history of periodontal treatment for pocket reduction (OR 7.99, p = 0.006), KT (OR 0.62, p < 0.001), cBBD (OR 2.30, p = 0.015), GT 1.5 mm from the gingival margin (OR 0.18, p = 0.04) and 3D profile 1 mm from the gingival margin (OR 1.04, p = 0.001). The depth of midfacial GR was significantly correlated to previous history of periodontal treatment (OR 0.96, p = 0.001), KT (OR −0.18, p < 0.001), presence of bone fenestration (OR 0.24, p = 0.044), and cBBD (OR 0.43, p < 0.001). The depth of midfacial GR was also the only factor associated with patient‐reported esthetics (OR −3.38, p = 0.022), while KT (OR 0.77, p = 0.018) and AG (OR 0.82, p = 0.047) were significantly correlated with patient‐reported dental hypersensitivity.ConclusionsSeveral risk indicators of midfacial and interproximal GR in the esthetic region were identified. The use of imaging technologies allowed for detection of parameters associated with the conditions of interest, and, therefore, their incorporation in future clinical studies is advocated. Ultrasonography could be preferred over CBCT for a noninvasive assessment of periodontal phenotype.
Characterization of natural killer and cytotoxic T‐cell immune infiltrates in pancreatic ductal adenocarcinoma
Authors: Persky Julia , Cruz Sylvia M. , Darrow Morgan A. , Judge Sean J. , Li Yueju , Bold Richard J. , Karnezis Anthony N. , Matsukuma Karen E. , Qi Lihong , Canter Robert J. 
Published: January 2024

AbstractBackground and ObjectivesPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor response to systemic therapies, including immunotherapy. Given the immunotherapeutic potential of natural killer (NK) cells, we evaluated intratumoral NK cell infiltrates along with cytotoxic T cells in PDAC to determine their association with patient outcomes.MethodsWe analyzed tumors from 93 PDAC patients treated from 2012 to 2020. Predictor variables included tumor‐infiltrating lymphocytes (TILs), T‐cell markers (CD3, CD8, CD45RO), NK marker (NKp46), and NK inhibitory marker (major histocompatibility complex class I [MHC‐I]) by immunohistochemistry. Primary outcome variables were recurrence‐free survival (RFS) and overall survival (OS).ResultsMean TILs, CD3, and NKp46 scores were 1.3 ± 0.63, 20.6 ± 17.5, and 3.1 ± 3.9, respectively. Higher expression of CD3 and CD8 was associated with higher OS, whereas NK cell infiltration was not associated with either RFS or OS. There was a tight positive correlation between MHC‐I expression and all T‐cell markers, but not with NKp46.ConclusionsOverall NK cell infiltrates were low in PDAC and did not predict clinical outcomes, whereas T‐cell infiltrates did. Further characterization of the immune infiltrate in PDAC, including inhibitory signals and suppressive cell types, may yield better biomarkers of prognosis and immune targeting in this refractory disease.
Soybean Oil‐Based 3D Printed Mesh Designed for Guided Bone Regeneration (GBR) in Oral Surgery
Authors: Bragaglia Mario , Sciarretta Francesca , Filetici Pierfrancesco , Lettieri‐Barbato Daniele , Dassatti Leonardo , Nicoletti Fabrizio , Sibilia Diego , Aquilano Katia , Nanni Francesca 
Published: January 2024

AbstractThis study aims to obtain a cyto‐compatible 3D printable bio‐resin for the manufacturing of meshes designed from acquired real patients’ bone defect to be used in future for guided bone regeneration (GBR), achieving the goal of personalized medicine, decreasing surgical, recovery time, and patient discomfort. To this purpose, a biobased, biocompatible, and photo‐curable resin made of acrylated epoxidized soybean oil (AESO) diluted with soybean oil (SO) is developed and 3D printed using a commercial digital light processing (DLP) 3D printer. 3D printed samples show good thermal properties, allowing for thermally‐based sterilization process and mechanical properties typical of crosslinked natural oils (i.e., E = 12 MPa, UTS = 1.5 MPa), suitable for the GBR application in the oral surgery. The AESO‐SO bio‐resin proves to be cytocompatible, allowing for fibroblast cells proliferation (viability at 72 h > 97%), without inducing severe inflammatory response when co‐cultured with macrophages, as demonstrated by cytokine antibody arrays, that is anyway resolved in the first 24 h. Moreover, accelerated degradation tests prove that the bio‐resin is biodegradable in hydrolytic environments.
ABHD6 suppresses colorectal cancer progression via AKT signaling pathway
Authors: Xiong Xiaoyu , Yang Changjiang , Jin Yiteng , Zhang Rui , Wang Shuo , Gan Lin , Hou Sen , Bao Yudi , Zeng Zexian , Ye Yingjiang , Gao Zhidong 
Published: January 2024

AbstractColorectal cancer (CRC) continues to be a prevalent malignancy, posing a significant risk to human health. The involvement of alpha/beta hydrolase domain 6 (ABHD6), a serine hydrolase family member, in CRC development was suggested by our analysis of clinical data. However, the role of ABHD6 in CRC remains unclear. This study seeks to elucidate the clinical relevance, biological function, and potential molecular mechanisms of ABHD6 in CRC. We investigated the role of ABHD6 in clinical settings, conducting proliferation, migration, and cell cycle assays. To determine the influence of ABHD6 expression levels on Oxaliplatin sensitivity, we also performed apoptosis assays. RNA sequencing and KEGG analysis were utilized to uncover the potential molecular mechanisms of ABHD6. Furthermore, we validated its expression levels using Western blot and reactive oxygen species (ROS) detection assays. Our results demonstrated that ABHD6 expression in CRC tissues was notably lower compared to adjacent normal tissues. This low expression correlated with a poorer prognosis for CRC patients. Moreover, ABHD6 overexpression impeded CRC cell proliferation and migration while inducing G0/G1 cell cycle arrest. In vivo experiments revealed that downregulation of ABHD6 resulted in an increase in tumor weight and volume. Mechanistically, ABHD6 overexpression inhibited the activation of the AKT signaling pathway and decreased ROS levels in CRC cells, suggesting the role of ABHD6 in CRC progression via the AKT signaling pathway. Our findings demonstrate that ABHD6 functions as a tumor suppressor, primarily by inhibiting the AKT signaling pathway. This role establishes ABHD6 as a promising prognostic biomarker and a potential therapeutic target for CRC patients.
Can digital technology remove impediments in the dual circulation?—An enterprise cycle efficiency perspective
Authors: Ran Lijun , Wang Kang , Sun Jiamin , Qu Yahui 
Published: January 2024

AbstractDigital technology is an important tool to smooth the dual circulation. This paper empirically examines the impact of digital technology on the enterprise dual circulation and its mechanism based on the data of enterprises in ZGC from 2013 to 2019. It shows that digital technology can significantly promote enterprise dual circulation, and this conclusion still holds after a series of robustness tests. Mechanisms analyzed found that digital technology promotes enterprise dual circulation by unclogging blockages in the production, distribution, circulation, and consumption chain. Further research found that digital technology facilitates NSOEs more significantly than SOEs. Meanwhile, the application of e‐commerce, big data, cloud computing, mobile Internet, Internet finance, and Internet of Things promote more obviously compared with intelligent hardware. This paper provides micro‐empirical evidence that digital technologies smooth the dual circulation.
Pandemic fatigue and clinical front‐line medical staff health, job status during the COVID‐19 pandemic: A cross‐sectional survey after the lifting of epidemic restrictions
Authors: Zhang Yiqing , Xu Qihang , Ma Jingjing , Wang Zhengzheng , Lu Shunshun 
Published: January 2024

AbstractAimThis study aimed to measure pandemic fatigue, physical and mental health, and job status of front‐line medical staff in Ningbo. And to identify factors associated with pandemic fatigue.BackgroundThere was an acute increase in fatigue symptoms at the COVID‐19 pandemic onset. The front‐line medical staff is particularly vulnerable to fatigue due to their high‐intensity work.DesignThis was a descriptive, cross‐sectional study conducted using an online survey that included demographic data, investigation of COVID‐19 history and job status. The Fatigue Assessment Scale, GAD‐7 score and Sleep Quality Scale were used to collect data from 479 front‐line medical staff.MethodsThe study involved 479 front‐line medical staff in Ningbo, China. The survey was conducted using an online questionnaire that included demographic data, investigation of COVID‐19 history and job status. The Fatigue Assessment Scale, GAD‐7 score and Sleep Quality Scale were used to collect data.ResultsThe results showed that of the 479 participants, 393 (82%) reported pandemic fatigue, 393 (82%) reported job satisfaction and 433 (90.4%) identified with their sense of job value. Sleep quality, work with a fever, economic subsidies for fighting COVID‐19 and recognizing professional value were significantly correlated with pandemic fatigue.ConclusionsAs the COVID‐19 pandemic challenges front‐line medical workers, implementing measures is essential. Health policy implementers could provide sufficient front‐line medical staff to ensure rest in case of infection, promote sleep quality and foster professional value and financial subsidies in units.Relevance to clinical practiceThe study shows how pandemic fatigue affects front‐line medical staff during the COVID‐19 pandemic and suggests measures to support them, including promoting sleep quality, providing rest for infected staff, fostering professional value and financial subsidies. The recommendations are relevant to clinical practice as they help support medical staff and ensure high‐quality care for patients during the pandemic.Patient or Public ContributionNo Patient or Public Contribution. Not applicable.
Synthesis and properties of RNA constrained by a 2’‐O‐disulfide bridge
Authors: Traoré Diallo , Biecher Elisa , Mallet Manon , Rouanet Sonia , Vasseur Jean‐Jacques , Smietana Michael , Dupouy Christelle 
Published: January 2024

AbstractWe recently reported the properties of RNA hairpins constrained by a dimethylene (DME) disulfide (S−S) linker incorporated between two adjacent nucleosides in the loop and showed that this linker locked the hairpin conformation thus disturbing the duplex/hairpin equilibrium. We have now investigated the influence of the length of the linker and synthesized oligoribonucleotides containing diethylene (DEE) and dipropylene (DPE) S−S bridges. This was achieved via the preparation of building blocks, namely 2′‐O‐acetylthioethyl (2′‐O‐AcSE) and 2′‐O‐acetylthiopropyl (2′‐O‐AcSP) uridine phosphoramidites, which were successfully incorporated into RNA sequences. Thermal denaturation analysis revealed that the DEE and DPE disulfide bridges destabilize RNA duplexes but do not disrupt the hairpin conformation. Furthermore, our investigation of the duplex/hairpin equilibrium indicated that sequences modified with DME and DEE S−S linkers predominantly lock the hairpin form, whereas the DPE S−S linker provides flexibility. These findings highlight the potential of S−S linkers to study RNA interactions.
Porous‐structured vermiculite/polybutylene adipate terephthalate composite films: The morphology, mechanical properties, and nonisothermal degradation kinetics
Authors: Xu Yuhuan , Zhou Teng , Shang Xiaoyu , Zhang Daohai , Liu Xiaonan , Shuhao Qin 
Published: January 2024

AbstractTo examine the impact of vermiculite (VMT) on the environmental and physical aspects of polybutylene terephthalate (PBAT), the thermal degradation behavior of VMT/polybutylene terephthalate polyadipate (VMT/PBAT) composite films was investigated by using the thermogravimetric analysis (TGA). To ensure precise calculation of the specific activation energy values of VMT/PBAT composite films in thermal degradation performance experiments, the Kissinger method (K‐method) and Flynn–Wall–Ozawa method (FWO method) were utilized. Additionally, the reaction mechanism was analyzed using the Coats–Redfern equation (CR equation). The introduction of VMT into the PBAT co‐polyester structure leads to an increase in the thermal degradation activation energy Ek of composite films.; the apparent activation energies were calculated by the Coats–Redfern method for different reaction mechanisms, and the interfacial diffusion reaction mechanism of the composite film was determined, with a thermal degradation reaction principle properties of g(α) = [1 − (1 − α)]2 and the number of reaction steps of 2.Highlights
VMT/PBAT composite films prepared using a simple method.
Analyzing nonisothermal degradation kinetics using K‐method and FWO method.
Analyzing the degradation mechanisms using the Coats–Redfern equation.
Addition of VMT enhances the thermal degradation properties of composite films.
Addition of VMT reduces the mechanical properties of the composite film.
Alterations in the hub structure of whole‐brain functional networks in patients with drug‐naïve schizophrenia: Insights from electroencephalography‐based research
Authors: Ishibashi Tomoaki , Nobukawa Sou , Tobe Mayuna , Kikuchi Mitsuru , Takahashi Tetsuya 
Published: January 2024

AbstractAimThis study aimed to identify atypical hubs in the whole‐brain networks of patients with schizophrenia (SZ) and examine the effects of antipsychotic medications, using electroencephalography (EEG) data.MethodsWe estimated the functional connectivity across all electrodes by applying the phase lag index to the EEG signals of 21 drug‐naïve patients with SZ and 31 age‐matched healthy controls. Betweenness centrality (BC), a measure of hub status, was calculated for each electrode and frequency band. Data from 14 patients were re‐evaluated after initiating treatment with antipsychotic medications.ResultsBC values decreased significantly at the Fz site in the beta band, decreased significantly at Pz in the gamma band, and increased significantly at O1 in the gamma band among patients with SZ. These changes persisted after antipsychotic treatment and were unrelated to clinical symptoms.ConclusionThe abnormal hub topology we observed, especially in the high‐frequency band, may reflect the pathophysiology of SZ, and this study highlights the utility of BC analysis of EEG data for detecting alterations in the whole‐brain networks of patients with SZ.
The impact of future self‐continuity on college students' online learning engagement: A moderated mediation model
Authors: Shen Junxian , Zhang Hongfeng , Zheng Jiansong 
Published: January 2024

AbstractOnline learning is becoming more and more common, so how to maintain learners' online learning engagement is very important. This study aims to explore the impact of future self‐continuity on college students' online learning engagement and its underlying mechanism of action. We utilized the Future Self‐Continuity Questionnaire, the Learning Self‐regulation Questionnaire, the Implicit Theories of Intelligence Scale, and the Online Learning Engagement Scale to measure the corresponding variables of a sample with 476 college students. The results revealed that future self‐continuity, autonomous motivation, and implicit theories of intelligence were significant positive predictors of student's online learning engagement. The positive association between future self‐continuity and student's online learning engagement was mediated by the autonomous motivation. Moreover, the mediating effect of autonomous motivation was moderated by the implicit theories of intelligence. Relation to the individual endorsing entity theorists, the mediating effect of autonomous motivation was stronger for individual holding increment theorists. Future self‐continuity has an impact on college students' online learning engagement levels directly or indirectly through autonomous motivation. Attention should be paid to the cultivation training of learners' future scenario imagination and autonomous motivation to facilitate their maintenance of focused online learning engagement.
A preliminary comparison study of teachers' resilience in Greece and Poland
Authors: Boczkowska Magdalena , Daniilidou Athena , Platsidou Maria 
Published: January 2024

AbstractThis study aimed to assess the applicability of the Teachers' Resilience Scale (TRS) among Greek and Polish teachers and explore whether nationality and sociodemographic factors influence teachers' engagement with resilience protective factors. A total of 1622 teachers participated, providing TRS responses and sociodemographic information. Greek and Polish teachers exhibited similar assessments of protective factors, except for Social Competence and Peer Support, where Greek teachers scored higher. Greek teachers also reported higher overall resilience scores than Polish teachers. Gender differences were observed, with women scoring higher in Personal Competencies and Persistence than men. Marital status influenced Social Skills and Peer Support and Family Cohesion, favoring those married and/or in relationships. Additionally, teachers in primary and secondary education reported higher scores in Personal Competencies and Persistence compared to kindergarten teachers. These findings contribute to understanding how individuals and social groups, despite facing diverse adversities, tend to employ similar strategies to bolster and safeguard their resilience.
Hope, childhood experiences, and achievement motivation in high school students: A mixed methods study
Authors: Polat Meyrem Ayça , Aliyev Ramin 
Published: January 2024

AbstractThe aim of the study is to examine the role of childhood experiences and achievement motivation in high school students' hope levels. The quantitative (N = 686, 43.9% females and 56.1% males, aged between 13 and 19; Mage = 16.02, standard deviation = 1.23) and qualitative data of the study, in which enriched design was used, were collected from high school students studying in the Southeast of Turkey. Hierarchical regression was used in the quantitative part of the study and content analysis was carried out in the qualitative part. It is seen that the results in the qualitative analysis part largely coincide with the results in the quantitative part. The results denote that high school students have high hope levels. Also, according to the results, there is a negative, low‐level, and significant relationship between childhood experiences and hope, and a positive and moderately significant relationship between hope and achievement motivation. Although childhood experiences and achievement motivation significantly predict the level of hope, it is concluded that achievement motivation contributes more to the hope‐related variance which is explained. The findings reveal the value of achievement motivation and childhood experiences in understanding adolescents' hope multidimensionally.
Respiratory function testing for guiding ventilator mode conversion in congenital diaphragmatic hernia
Authors: Kimura Sasagu , Toyoshima Katsuaki , Shimokaze Tomoyuki , Katsumata Kaoru , Saito Tomoko , Hoshino Rikuo 
Published: January 2024

AbstractIntroductionFor patients with a congenital diaphragmatic hernia, conventional mechanical ventilation (CMV) and high‐frequency oscillatory ventilation (HFOV) are used in initial ventilatory management. HFOV has recently been recommended as a rescue therapy; however, we use HFOV for initial ventilation management, with a preoperative challenge test for CMV conversion and respiratory function testing at the time of CMV conversion. We aimed to compare patient characteristics between CMV conversion‐ and HFOV‐preferred treatment groups.MethodsVentilator settings and blood gases were retrospectively evaluated pre‐ and post‐CMV conversion, and respiratory function tests for compliance of the respiratory system (Crs) and for resistance of the respiratory system (Rrs) were performed during the trial to CMV conversion.ResultsNo differences were observed between the CMV conversion‐ and HFOV‐preferred groups regarding gestational age, birth weight, and observed/expected lung area‐to‐head circumference ratios. The median Crs (ml/cmH2O/kg) and Rrs (cmH2O･kg/L/s) in the CMV conversion‐ and HFOV‐preferred groups was 0.42 versus 0.53 (p = .44) and 467 versus 327 (p = .045), respectively. The pre and posttrial amount of change in blood gas levels and ventilator parameters in the CMV conversion‐ and HFOV‐preferred groups were as follows: mean airway pressure, −2.0 versus 0 cmH2O; partial pressure of carbon dioxide, 6.1 versus 2.9 Torr; alveolar‐arterial oxygen difference, −39.5 versus −50 Torr; and oxygenation index, −1.0 versus −0.6; respectively.ConclusionRespiratory function tests were useful in tailoring ventilator settings. Patients with high Rrs values responded better to CMV conversion.