bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spatiotemporal dynamics of semantic integration in the human brain
Authors: Murphy Elliot , Forseth Kiefer J. , Donos Cristian , Snyder Kathryn M. , Rollo Patrick S. , Tandon Nitin 
Published: October 2023

AbstractLanguage depends critically on the integration of lexical information across multiple words to derive semantic concepts. Limitations of spatiotemporal resolution have previously rendered it difficult to isolate processes involved in semantic integration. We utilized intracranial recordings in epilepsy patients (n = 58) who read written word definitions. Descriptions were either referential or non-referential to a common object. Semantically referential sentences enabled high frequency broadband gamma activation (70–150 Hz) of the inferior frontal sulcus (IFS), medial parietal cortex, orbitofrontal cortex (OFC) and medial temporal lobe in the left, language-dominant hemisphere. IFS, OFC and posterior middle temporal gyrus activity was modulated by the semantic coherence of non-referential sentences, exposing semantic effects that were independent of task-based referential status. Components of this network, alongside posterior superior temporal sulcus, were engaged for referential sentences that did not clearly reduce the lexical search space by the final word. These results indicate the existence of complementary cortical mosaics for semantic integration in posterior temporal and inferior frontal cortex.
Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy
Authors: Wang Kaiyuan , Zhang Xuanbo , Ye Hao , Wang Xia , Fan Zhijin , Lu Qi , Li Songhao , Zhao Jian , Zheng Shunzhe , He Zhonggui , Ni Qianqian , Chen Xiaoyuan , Sun Jin 
Published: October 2023

AbstractCytokine therapy, involving interleukin-15 (IL-15), is a promising strategy for cancer immunotherapy. However, clinical application has been limited due to severe toxicity and the relatively low immune response rate, caused by wide distribution of cytokine receptors, systemic immune activation and short half-life of IL-15. Here we show that a biomimetic nanovaccine, developed to co-deliver IL-15 and an antigen/major histocompatibility complex (MHC) selectively targets IL-15 to antigen-specific cytotoxic T lymphocytes (CTL), thereby reducing off-target toxicity. The biomimetic nanovaccine is composed of cytomembrane vesicles, derived from genetically engineered dendritic cells (DC), onto which IL-15/IL-15 receptor α (IL-15Rα), tumor-associated antigenic (TAA) peptide/MHC-I, and relevant costimulatory molecules are simultaneously anchored. We demonstrate that, in contrast to conventional IL-15 therapy, the biomimetic nanovaccine with multivalent IL-15 self-transpresentation (biNV-IL-15) prolonged blood circulation of the cytokine with an 8.2-fold longer half-life than free IL-15 and improved the therapeutic window. This dual targeting strategy allows for spatiotemporal manipulation of therapeutic T cells, elicits broad spectrum antigen-specific T cell responses, and promotes cures in multiple syngeneic tumor models with minimal systemic side effects.
Manipulating coordination environment for a high-voltage aqueous copper-chlorine battery
Authors: Zhang Xiangyong , Wei Hua , Li Shizhen , Ren Baohui , Jiang Jingjing , Qu Guangmeng , Lv Haiming , Liang Guojin , Chen Guangming , Zhi Chunyi , Li Hongfei , Liu Zhuoxin 
Published: October 2023

AbstractAqueous copper-based batteries have many favourable properties and have thus attracted considerable attention, but their application is limited by their low operating voltage originating from the high potential of copper negative electrode (0.34 V vs. standard hydrogen electrode). Herein, we propose a coordination strategy for reducing the intrinsic negative electrode redox potential in aqueous copper-based batteries and thus improving their operating voltage. This is achieved by establishing an appropriate coordination environment through the electrolyte tailoring via Cl− ions. When coordinated with chlorine, the intermediate Cu+ ions in aqueous electrolytes are successfully stabilized and the electrochemical process is decoupled into two separate redox reactions involving Cu2+/Cu+ and Cu+/Cu0; Cu+/Cu0 results in a redox potential approximately 0.3 V lower than that for Cu2+/Cu0. Compared to the coordination with water, the coordination with chlorine also results in higher copper utilization, more rapid redox kinetics, and superior cycle stability. An aqueous copper-chlorine battery, harnessing Cl−/Cl0 redox reaction at the positive electrode, is discovered to have a high discharge voltage of 1.3 V, and retains 77.4% of initial capacity after 10,000 cycles. This work may open up an avenue to boosting the voltage and energy of aqueous copper batteries.
Anaerobic photoinduced Cu(0/I)-mediated Glaser coupling in a radical pathway
Authors: Zhang Siqi , Zhao Liang 
Published: October 2023

AbstractThe reaction mechanism of the historic copper-catalyzed Glaser coupling has been debated to be based on redox cycles of Cu ions in specific oxidation states or on a radical mechanism based on Cu(0)/Cu(I). Here, the authors demonstrate two coexisting Glaser coupling pathways which can be differentiated by anaerobic/irradiation or aerobic reaction conditions. Without O2, copper(I) acetylides undergo a photo-excited pathway to generate highly reactive alkynyl radicals, which combine together to form a homo-coupling product or individually react with diverse X-H (X = C, N, O, S and P) substrates via hydrogen atom transfer. With O2, copper(I) acetylides are oxidized to become a Cu-acetylide/Cu-O merged Cu(I/II) intermediate for further oxidative coupling. This work not only complements the radical mechanism for Glaser coupling, but also provides a mild way to access highly energetic alkynyl radicals for efficient organic transformations.
Pleasure before business: emotions and age effects on daily activity scheduling
Authors: La Malva Pasquale , Ceccato Irene , Di Crosta Adolfo , D’Angelo Nico , Marin Anna , Bartolini Emanuela , D’Intino Eleonora , Mammarella Nicola , Palumbo Riccardo , Palumbo Rocco , Di Domenico Alberto 
Published: October 2023

AbstractActivity scheduling represents a key process in daily life, involving the evaluation of the costs and benefits of the resources to be invested, but also a preference for when to engage in pleasant or unpleasant activities. Aging affects the evaluation processes and individual preferences due to changes in cognitive functioning and life perspectives. The present study investigated the differences between younger adults (age range 19–33) and older adults (age range 65–87) in a task assessing preferential scheduling of activities. Participants were asked to schedule thirty emotional activities (positive, negative, or neutral) within a 30-day time window, assigning one activity for each day. Results indicated that older adults, but not younger adults, planned positive activities closer in time, supporting the “positivity effect”. Also, both younger and older adults tended to postpone negative activities, scheduling them in the last days. Finally, for older adults only, negative affect was associated with the tendency to put positive activities closer in time. Present findings showed age-specific effects of emotional content on daily activity scheduling.
Effects of resilience and timing of adverse and adaptive experiences on interpersonal behavior: a transdiagnostic study in a clinical sample
Authors: Barton Barbara B. , Ehring Thomas , Reinhard Matthias A. , Goerigk Stephan , Wüstenberg Torsten , Musil Richard , Amann Benedikt L. , Jobst Andrea , Dewald-Kaufmann Julia , Padberg Frank 
Published: October 2023

AbstractAdverse childhood experiences (ACE) have been linked to less prosocial behavior during social exclusion in vulnerable groups. However, little is known about the impact of the timing of ACE and the roles of protective factors. Therefore, this study investigated the association of the behavioral response to experimental partial social exclusion with adverse and adaptive experiences across age groups and resilience in clinical groups with persistent depressive disorder and borderline personality disorder, i.e., groups with high ACE, and in healthy controls (HC) (N = 140). Adverse and adaptive experiences during childhood, youth, and adulthood were assessed with the Traumatic Antecedents Questionnaire, and resilience was measured with the Connor Davidson Resilience Scale. A modified version of the Cyberball paradigm was used to assess the direct behavioral response to partial social exclusion. In patients, adverse events during youth (B = − 0.12,p = 0.016) and adulthood (B = − 0.14,p = 0.013) were negatively associated with prosocial behavior, whereas in the HC sample, adaptive experiences during youth were positively associated with prosocial behavior (B = 0.25,p = 0.041). Resilience did not mediate these effects. The findings indicate that critical events during youth may be particularly relevant for interpersonal dysfunction in adulthood.
Experimental investigation on fatigue life and tensile strength of carbon fiber-reinforced PLA composites based on fused deposition modeling
Authors: Kargar Ehsan , Ghasemi-Ghalebahman Ahmad 
Published: October 2023

AbstractFused deposition modeling (FDM) is a widely used additive manufacturing (AM) method that offers great flexibility in fabricating complex geometries without requiring expensive equipment. However, compared to other manufacturing methods, FDM-produced parts generally exhibit lower strength and fatigue life. To overcome this limitation, researchers have explored the use of fibers and reinforcements to enhance the mechanical properties of FDM parts. Nevertheless, the performance of FDM-produced parts can be significantly affected by various manufacturing parameters, including infill density, which is a key factor in balancing time and cost. In this study, the tensile strength and fatigue life of carbon fiber-reinforced polylactic acid (PLA) composites produced by FDM were investigated by varying the infill density (50 and 75%) and raster angle (0°, 45°, and 90°). The effects of 100% filling density, raster width, and nozzle diameter on mechanical properties were also examined. The experimental results demonstrated that increasing the infill density and decreasing the raster angle can enhance the tensile strength, although the fatigue behavior was found to be more complex and dependent on the infill density. The optimal parameters for producing FDM parts with improved mechanical properties were identified based on the analysis of the tensile strength and fatigue life data. This research has yielded significant findings concerning the diverse fatigue behavior associated with the raster angle at different infill densities. Specifically, noteworthy observations reveal that a raster angle of 45 degrees at 50% infill density, and a raster angle of 0 degrees at 75% infill density, exhibited the most prolonged fatigue life. This outcome can be ascribed to the specific loading conditions and the inherent strength of the sediment layer at the critical point of stress concentration.
Artificial intelligence extracts key insights from legal documents to predict intimate partner femicide
Authors: Garcia-Vergara Esperanza , Almeda Nerea , Fernández-Navarro Francisco , Becerra-Alonso David 
Published: October 2023

AbstractLegal documents serve as valuable repositories of information pertaining to crimes, encompassing not only legal aspects but also relevant details about criminal behaviors. To date and the best of our knowledge, no studies in the field examine legal documents for crime understanding using an Artificial Intelligence (AI) approach. The present study aims to fill this research gap by identifying relevant information available in legal documents for crime prediction using Artificial Intelligence (AI). This innovative approach will be applied to the specific crime of Intimate Partner Femicide (IPF). A total of 491 legal documents related to lethal and non-lethal violence by male-to-female intimate partners were extracted from the Vlex legal database. The information included in these documents was analyzed using AI algorithms belonging to Bayesian, functions-based, instance-based, tree-based, and rule-based classifiers. The findings demonstrate that specific information from legal documents, such as past criminal behaviors, imposed sanctions, characteristics of violence severity and frequency, as well as the environment and situation in which this crime occurs, enable the correct detection of more than three-quarters of both lethal and non-lethal violence within male-to-female intimate partner relationships. The obtained knowledge is crucial for professionals who have access to legal documents, as it can help identify high-risk IPF cases and shape strategies for preventing crime. While this study focuses on IPF, this innovative approach has the potential to be extended to other types of crimes, making it applicable and beneficial in a broader context.
Visualization analysis of research hotspots on structural topology optimization based on CiteSpace
Authors: Zhong Yi , Jiang Xue-tao , Yang Yong , Xu Ben-lian , Zhu Qi-xin , Wang Lei , Dong Xin-feng 
Published: October 2023

AbstractStructural topology optimization has gained widespread attention due to more possibilities of innovative structural design. The current research focus/hotspots, application areas, main research scholars, institutions and the countries involved in structural topology optimization are visually presented through clustering and visual analysis based on CiteSpace. The four metric dimensions of the literatures in this paper are as follows: annual quantity of papers and core countries, core authors and co-authors’ institutions, hotspots and burst terms, and the highly co-cited papers. The results show the research hotspots in this field are concentrated on keywords such as "level set method", "sensitivity analysis", "homogenization", "genetic algorithm", etc. Regarding the research frontier, “moving morphable component (MMC)”, “additive manufacturing (AM)” and “deep learning” are hot topics. In addition, Y. Sui, Z. Kang and O. Sigmund, etc. have high publications. M. Bendsøe and O. Sigmund have high citations. Dalian University of Technology, Technical University of Denmark, etc. are prominent institutions. Moreover, China accounts for more than 34% in the terms of original WOS literatures following by the USA and Australia. This paper could identify structural topology optimization development patterns for the scholars concerned with this field, especially novices, to quickly focus and track the research priorities.
Rapid and selective actuation of 3D-printed shape-memory composites via microwave heating
Authors: An Soo-Chan , Lim Yeonsoo , Jun Young Chul 
Published: October 2023

AbstractThree-dimensional (3D) printing allows the fabrication of complex shapes with high resolutions. However, the printed structures typically have fixed shapes and functions. Four-dimensional printing allows the shapes of 3D-printed structures to be transformed in response to external stimuli. Among the external stimuli, light has unique advantages for remote thermal actuation. However, light absorption in opaque structures occurs only near the sample surface; thus, actuation can be slow. Here, we propose and experimentally demonstrate the rapid and selective actuation of 3D-printed shape-memory polymer (SMP) composites using microwave heating. The SMP composite filaments are prepared using different amounts of graphite flakes. Microwave radiation can penetrate the entire printed structures and induce rapid heating. With sufficient graphite contents, the printed SMP composites are heated above their glass transition temperature within a few seconds. This leads to rapid thermal actuation of the 3D-printed SMP structures. Finally, dual-material 3D printing is demonstrated to induce selective microwave heating and control actuation motion. Our experiments and simulations indicate that microwave heating of SMP composites can be an effective method for the rapid and selective actuation of complex structures.
Anatomical cardiac and electrocardiographic axes correlate in both upright and supine positions: an upright/supine CT study
Authors: Norimatsu Togo , Nakahara Takehiro , Yamada Yoshitake , Yokoyama Yoichi , Yamada Minoru , Narita Keiichi , Jinzaki Masahiro 
Published: October 2023

AbstractThe correlation between the anatomical cardiac and electrocardiographic axes has been discussed for several years. Using upright computed tomography, this study aimed to reveal the relationship between the anatomical cardiac and electrocardiographic axes in both the supine and upright positions. Upright CT and standard supine CT were performed for healthy volunteers, following electrocardiography in both upright and supine position. On CT images, the coordinates of apex, the center of aortic valve (AV) and mitral valve (MV) were recorded, and the vectors and angles were calculated. Subcutaneous and visceral fat volume were semi-automatically calculated in a workstation. From a total 190 volunteers, 41 males were performed electrocardiography and included for this study. The QRS and anatomical axes (AV-apex and MV-apex axis) were significantly correlated in both supine and upright positions, while the angle of the AV-apex to Z axis was the most correlated (supine: r = − 0.54, p = 0.0002, upright: r = − 0.47, p = 0.0020). The anatomical axis moved in the dorsal and caudal directions from the supine to upright position. Multiple regression analysis revealed that the anatomical axis from the AV-apex to the Z-axis was determined according to age, body height, subcutaneous and visceral fat volumes.
Assessing the use of minimally invasive self-sampling at home for long-term monitoring of the microbiota within UK families
Authors: Nikolaou E. , German E. L. , Howard A. , Nabwera H. M. , Matope A. , Robinson R. , Shiham F. , Liatsikos K. , McNamara C. , Kattera S. , Carter K. , Parry C. M. , Read J. M. , Allen S. J. , Urban B. C. , Hawcutt D. B. , Hill H. , Collins A. M. , Ferreira D. M. 
Published: October 2023

AbstractMonitoring the presence of commensal and pathogenic respiratory microorganisms is of critical global importance. However, community-based surveillance is difficult because nasopharyngeal swabs are uncomfortable and painful for a wide age range of participants. We designed a methodology for minimally invasive self-sampling at home and assessed its use for longitudinal monitoring of the oral, nasal and hand microbiota of adults and children within families. Healthy families with two adults and up to three children, living in and near Liverpool, United Kingdom, self-collected saliva, nasal lining fluid using synthetic absorptive matrices and hand swabs at home every two weeks for six months. Questionnaires were used to collect demographic and epidemiological data and assess feasibility and acceptability. Participants were invited to take part in an exit interview. Thirty-three families completed the study. Sampling using our approach was acceptable to 25/33 (76%) families, as sampling was fast (76%), easy (76%) and painless (60%). Saliva and hand sampling was acceptable to all participants of any age, whereas nasal sampling was accepted mostly by adults and children older than 5 years. Multi-niche self-sampling at home can be used by adults and children for longitudinal surveillance of respiratory microorganisms, providing key data for design of future studies.
Statistical study of a large and cleaned sample of ultraluminous and hyperluminous X-ray sources
Authors: Tranin Hugo , Webb Natalie , Godet Olivier , Quintin Erwan 
Published: October 2023

Context. Ultraluminous and hyperluminous X-ray (ULX and HLX) sources could constitute interesting laboratories to further improve our understanding of the supermassive black hole growth through super-Eddington accretion episodes and successive mergers of lighter holes. ULXs are thought to be powered by super-Eddington accretion onto stellar-mass compact objects, while HLXs are of an unknown nature, but they could be good candidates for accreting intermediate mass black holes (IMBHs). However, a significant portion of the sample of ULX and HLX candidates derived from catalogue searches are in fact background active galactic nuclei (AGN).
Aims. Here we build samples of ULXs and HLXs from the three largest X-ray catalogues available, compiled from XMM-Newton, Swift-XRT, and Chandra detections, and the GLADE catalogue containing 1.7 million galaxies at D < 1000 Mpc. We aim to characterise the frequency, environment, hardness, and variability of ULXs and HLXs to better assess their differences and understand their populations.
Methods. After a thorough classification of these X-ray sources, we were able to remove ∼42% of sources with a signal-to-noise ratio (S/N) > 3 which were shown to be contaminants, to obtain the cleanest sample of ULXs and HLXs to date. From a sample of 1342 ULXs and 191 HLXs detected with a S/N > 3σ, we study the occupation fraction, hardness, variability, radial distribution, and preferred environment of the sources. We built their Malmquist-corrected X-ray luminosity functions (XLFs) and compared them with previous studies. Thanks to the unprecedented size of the sample, we were able to statistically compare ULXs and HLXs and assess the differences in their nature. The interpretation of HLXs as IMBHs is investigated.
Results. A significant break is seen in the XLF at ∼1040 erg s−1. With our ULX sample, containing ≲2% of contaminants, we are able to confirm that ULXs are located preferentially in spiral galaxies and galaxies with higher star formation rates. While X-ray binaries (XRBs), ULXs, and most HLXs share common hardness and variability distributions, a fraction of HLXs appear significantly softer. Unlike ULXs, HLXs seem to reside equally in spiral as well as lenticular and elliptical galaxies. We note that 35% of the HLX candidates have an optical counterpart, and we estimate the mass of 120 of them to be in the range of 2 × 103 − 105 M⊙. Most of the HLX population is found to be consistent with an accreting massive black hole in a dwarf galaxy satellite of the primary host. This diverse nature needs to be confirmed with deeper optical and infrared observations, as well as upcoming X-ray facilities.