bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnose und Differenzierung von kutanen Zysten mit optischer Kohärenztomographie: eine Fallserie
Authors: Hobelsberger Sarah , Gellrich Frank Friedrich , Steininger Julian , Beissert Stefan , Laske Jörg 
Published: December 2023

ZusammenfassungKutane zystische Läsionen (n = 35) wurden mit optischer Kohärenztomographie untersucht. Zysten waren sichtbar als hyporeflektive rundliche Raumforderung mit klarer Abgrenzung unter teils verdünnter Epidermis. Epidermalzysten, trichilemmale Zysten und Hidrozystome hatten einen linearen Rand, der das Zystenepithel darstellt, während mukoide Pseudozysten keinen linearen Rand aufwiesen. Trichilemmal- und Epidermoidzysten wiesen zudem einen hyperreflektiven Inhalt auf, welcher Keratin entspricht. Durch die Visualisierung des Randsaums und des Inhalts der Zyste war es möglich, zwischen verschiedenen Entitäten von Zysten zu differenzieren.
Protracted metallogenic and magmatic evolution of the Kirazlı epithermal Au-Ag and porphyry Cu deposits, Biga Peninsula, NW Turkey: evidence from zircon U-Pb, muscovite 40Ar/39Ar, and molybdenite Re-Os geochronology
Authors: Aluç Ali , Kuşcu İlkay , Ulyanov Alexey , Selby David , Antoine Clémentine , Spikings Richard , Moritz Robert 
Published: December 2023

AbstractThe Kirazlı deposit is located at the center of the Biga Peninsula metallogenic province, in a geological setting characterized by an extensional tectonic environment. A NNW-SSE trending high-sulfidation (HS) orebody with a total reserve of 33.86 Mt @ 0.69 g/t Au and 9.42 g/t Ag lies beneath the Kirazlı Main zone. A porphyry Cu orebody hosted by Eocene intrusive and volcanic rocks has been intersected by drilling within its vicinity. The HS epithermal deposit is hosted by a partly silicified and brecciated Oligocene volcanic and volcaniclastic sequence consisting mainly of basaltic andesite lava flow and lithic/crystal tuff. Lithogeochemistry and zircon U-Pb radiometric ages allow us to distinguish three distinct high-K calc-alkaline magmatic events at ca. 41, 38, and 32 Ma, sourced by metasomatized mantle melts, which have interacted with the crust during their ascent. Porphyry Cu mineralization took place at 36.7 ± 0.4 Ma (muscovite 40Ar/39Ar age) with subsequent re-opening and base metal deposition. Crosscutting quartz-pyrite-molybdenite veins were emplaced at 33.6 ± 0.2 Ma (molybdenite Re-Os age), and followed by the HS epithermal Au-Ag event at ca. 31 Ma, based on a previous study. Our radiometric data indicate that the Kirazlı deposit has recorded a long-lasting Cenozoic magmatic and metallogenic evolution during about 10 Myr. Our study demonstrates that successive, independent, and overprinting, but genetically unrelated, HS epithermal precious metal, hydrothermal Mo, base metal, and porphyry Cu systems have been active at the same location during protracted extensional tectonics of the Biga Peninsula.
eCerto—versatile software for interlaboratory data evaluation and documentation during reference material production
Authors: Lisec Jan , Recknagel Sebastian , Prinz Carsten , Vogel Kristin , Koch Matthias , Becker Roland 
Published: December 2023

AbstractThe statistical tool eCerto was developed for the evaluation of measurement data to assign property values and associated uncertainties of reference materials. The analysis is based on collaborative studies of expert laboratories and was implemented using the R software environment. Emphasis was put on comparability of eCerto with SoftCRM, a statistical tool based on the certification strategy of the former Community Bureau of Reference. Additionally, special attention was directed towards easy usability from data collection through processing, archiving, and reporting. While the effects of outlier removal can be flexibly explored, eCerto always retains the original data set and any manipulation such as outlier removal is (graphically and tabularly) documented adequately in the report. As a major reference materials producer, the Bundesanstalt für Materialforschung und -prüfung (BAM) developed and will maintain a tool to meet the needs of modern data processing, documentation requirements, and emerging fields of RM activity. The main features of eCerto are discussed using previously certified reference materials.
Graphical Abstract
Two-dimensional strain rate imaging study using a polarization camera and birefringent aqueous cellulose nanocrystal suspensions
Authors: Lane Connor , Baumann Frédéric , Rode David , Rösgen Thomas 
Published: December 2023

AbstractThe birefringence response of aqueous cellulose nanocrystal (CNC) suspensions in a two-dimensional laminar flow is measured and studied. The suspensions have CNC concentrations of 1.0 wt% (weight percentage) and 1.2 wt%. Cellulose nanocrystals are optically anisotropic rod-like particles that align when subjected to local velocity gradients, whereas at rest, they remain randomly orientated by Brownian motion. The alignment causes birefringence, a phenomenon also known as flow-induced birefringence. We study the flow through an additively manufactured flow channel and measure the amount of birefringence as well as the position of the refractive index axes by using polarizers and a polarization camera. With the help of reference data published in a previous study (Lane, Rode, et al., 2022a), strain rates are derived from the birefringence measurements and compared with numerical simulations. Two flow situations are studied, a plane Poiseuille flow and the flow around a cosine-shaped constriction. The experimentally derived shear rates for the plane Poiseuille flow are consistent with theoretical and computational results. The derived strain rates for the flow around the cosine-shaped constriction show an unexpected asymmetric profile, with the strain rates in the contraction zone being larger than in the expansion zone. The averaged orientation of the CNCs in the flow is linked to the position of the refractive index axes. In the contraction zone, the CNCs tend to align parallel to the flow, whereas in the expansion zone, the CNCs tend to align perpendicular to the flow. The results of this study are discussed in the context of previous, similar studies. The asymmetric strain rate profile around the cosine-shaped constriction is thought to originate from history effects, and the alignment of the CNCs is influenced by extensional rates.
3D-exoscopic microlaryngoscopy in phonosurgery for glottic insufficiency
Authors: Eckel Hans N. C. , Nolte Antonia , Otte Martin S. , Shabli Sami , Lang-Roth Ruth , Klußmann Jens P. , Hansen Kevin K. 
Published: December 2023

Abstract
Purpose
We hypothesized that using a 3D-exoscope (3Dex) in microlaryngoscopic phonosurgery is non-inferior to using a standard operating microscope (OM). To compare the above, we utilized a 3Dex and an OM for microlaryngoscopic vocal fold augmentation with autologous fat in patients with glottic insufficiency and compared the procedure itself and the long-term impact of vocal fold augmentation on subjective and objective voice parameters in both groups.

Methods
36 patients with glottic insufficiency received microlaryngoscopic laryngeal augmentation with autologous fat. A 3Dex was utilized in 24 cases for visualization and compared to twelve cases in which an OM was used. Voice parameters were evaluated over a period of twelve months.

Results
Comparison of operation time and voice parameters between the 3Dex and OM groups did not reveal significant differences. Significant improvement of mean voice quality in all parameters excluding roughness was observed at 3 and 6 months followed then by a slight decrease of voice quality parameters between the 6 and 12 months interval in both groups.

Conclusion
Our findings indicate no difference concerning operation time and outcome between the use of a 3Dex and an OM in phonosurgery. Our results highlight a significant voice improvement after vocal fold augmentation with autologous fat in glottic insufficiency mediated dysphonia. The smaller viewing system, better ergonomics for the primary surgeon and the assistant and a direct view for the entire surgical team make a 3Dex an interesting alternative for visualization in microlaryngoscopic phonosurgery.
Thermodynamic modelling of continental arc-adjacent magmatism: the Loicas Trough, N. Patagonia, Argentina
Authors: Traun Marie Katrine , Waterton P. , Søager N. , Waight T. E. , Iannelli S. B. , Folguera A. , Litvak V. D. 
Published: December 2023

AbstractContinental arcs are associated with volcanism concentrated into two main belts—the main arc and back arc, often separated by fold and thrust belts. The Loicas Trough, Argentina, is a post-orogenic extensional feature that obliquely cuts the fold and thrust belts. The trough hosts large Pliocene–Holocene volcanic centres, including Domuyo and Tromen, that lie between the main arc and back arc and thus provide a rare window into this setting. We present major and trace element data for the Loicas Trough, which we combine with geochemical modelling using the Magma Chamber Simulator (MCS) to explore the origin and evolution of the volcanism. The lavas display a wide continuous range from alkaline basalts to subalkaline rhyolites. Trace elements reveal variable extents of arc enrichment (2 < Nb/U < 28), which correlate with proximity to the trench and differentiation indices. Our results and MCS models indicate that the Loicas Trough parental magmas formed from compositionally zoned mantle. Best-fit models indicate that the differentiation occurs at middle and upper crustal levels, in sharp contrast to lower crustal hot zones beneath main arcs. Assimilation of partial crustal melts drives compositional evolution and obscures source signatures. Pure or high fraction end-member partial crustal melts are also identified at Domuyo based on their low Ba (~ 250 ppm) and moderate Sc contents (~ 8 ppm). We find evidence of similar lavas in transtensional settings adjacent to continental arcs worldwide, which do not adhere to the main versus back arc volcanism binary. We suggest the term arc-adjacent magmatism, where compositions are mainly controlled by extensive assimilation and reworking in the middle to upper crust.
RAWS4all project: validation of a new silicone model for robotic TAPP inguinal hernia repair
Authors: Gonçalves Mário Rui , Morales-Conde Salvador , Gaspar Reis Sofia , Carlos Alves Palmira , Novo de Matos José , Oliveira António , Marinho Ricardo , Cadime Irene , Castelo-Branco Sousa Miguel 
Published: December 2023

Abstract
Background
Trans-abdominal pre-peritoneal (TAPP) hernia repair is a complex procedure that presents several challenges. Even though, due to the high prevalence of inguinal hernia, TAPP technique is increasing in frequency and robotic Abdominal Wall Surgery (rAWS) is emerging as a valuable tool in this regard. Although inguinal TAPP procedure principles have been published and simulation is needed, the availability of validated models remains scarce.

Methods
A new low-cost model was developed to simulate inguinal rTAPP repair. For validity assessment, a new TAPP-specific fidelity questionnaire and assessment scale were developed to compare the performance of novices and experts in the simulated procedure. The models used were assessed at 60 min for execution and quality score.

Results
Twenty-five residents and specialists from all over the country participated in this study. Execution, quality, and global performance was higher in the seniors group compared to juniors (8.91 vs 6.36, p = 0.02; 8.09 vs 5.14, p < .001; and 17 vs. 11,5, p < .001, respectively). Overall fidelity was assessed as being very high [4.41 (3.5–5.0), α = .918] as well as face [4.31 (3.0–5.0), α = .867] and content validity [4.44 (3.2–5.0), α = .803]. Participants strongly agreed that the model is adequate to be used with the DaVinci® Robot [4.52 (3.5–5.0), α = .758].

Conclusion
This study shows face, content, and construct validity of the model for inguinal TAPP simulation, including for robotic surgery. Therefore, the model can be a valuable tool for learning, understanding, practicing, and mastering the TAPP technique prior to participating in the operating room.

Graphical abstract
Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark
Authors: Høyer Sidse , Heide-Jørgensen Uffe , Jensen Simon Kok , Nørgaard Mette , Slagle Cara , Goldstein Stuart , Christiansen Christian Fynbo 
Published: December 2023

Abstract
Background
We aimed to examine temporal changes in the annual rate of acute kidney injury (AKI) in Danish children and associated changes in patient characteristics including potential underlying risk factors.

Methods
In this population-based cohort study, we used plasma creatinine measurements from Danish laboratory databases to identify AKI episodes in children aged 0–17 years from 2007 to 2021. For each child, the first AKI episode per calendar year was included. We estimated the annual crude and sex- and age-standardized AKI rate as the number of children with an AKI episode divided by the total number of children as reported by census numbers. Using Danish medical databases, we assessed patient characteristics including potential risk factors for AKI, such as use of nephrotoxic medication, surgery, sepsis, and perinatal factors.

Results
In total, 14,200 children contributed with 16,345 AKI episodes over 15 years. The mean annual AKI rate was 148 (95% CI: 141–155) per 100,000 children. From 2007 to 2021, the annual AKI rate demonstrated minor year-to-year variability without any discernible overall trend. The highest AKI rate was recorded in 2007 at 174 (95% CI: 161–187) per 100,000 children, while the lowest rate occurred in 2012 at 129 (95% CI: 118–140) per 100,000 children. In 2021, the AKI rate was 148 (95% CI: 141–155) per 100,000 children. Characteristics of children with AKI were similar throughout the study period.

Conclusion
The rate of AKI among Danish children was stable from 2007 to 2021 with little variation in patient characteristics over time.

Graphical abstract
Seeing both sides: context-aware heterogeneous graph matching networks for extracting-related arguments
Authors: Mao Tiezheng , Yoshie Osamu , Fu Jialing , Mao Weixin 
Published: December 2023

AbstractOur research focuses on extracting exchanged views from dialogical documents through argument pair extraction (APE). The objective of this process is to facilitate comprehension of complex argumentative discourse by finding the related arguments. The APE comprises two stages: argument mining and argument matching. Researchers typically employ sequence labeling models for mining arguments and text matching models to calculate the relationships between them, thereby generating argument pairs. However, these approaches fail to capture long-distance contextual information and struggle to fully comprehend the complex structure of arguments. In our work, we propose the context-aware heterogeneous graph matching (HGMN) model for the APE task. First, we design a graph schema specifically tailored to argumentative texts, along with a heterogeneous graph attention network that effectively captures context information and structural information of arguments. Moreover, the text matching between arguments is converted into a graph matching paradigm and a multi-granularity graph matching model is proposed to handle the intricate relationships between arguments at various levels of granularity. In this way, the semantics of argument are modeled structurally and thus capture the complicated correlations between arguments. Extensive experiments are conducted to evaluate the HGMN model, including comparisons with existing methods and the GPT series of large language models (LLM). The results demonstrate that HGMN outperforms the state-of-the-art method.
Electronegativity as a new case for emergence and a new problem for reductionism
Authors: Cairns Monte 
Published: December 2023

AbstractThe potential reducibility of chemical entities to their physical bases is a matter of dispute between ontological reductionists on one hand, and emergentists on the other. However, relevant debates typically revolve around the reducibility of so-called ‘higher-level’ chemical entities, such as molecules. Perhaps surprisingly, even committed proponents of emergence for these higher-level chemical entities appear to accept that the ‘lowest-level’ chemical entities—atomic species—are reducible to their physical bases. In particular, the microstructural view of chemical elements, actively developed and defended by emergentists, appears to hold that the explanatory power of nuclear charge justifies being reductionist about atomic species. My first task in this paper is to establish that nuclear charge cannot ultimately provide explanations sufficient to justify a reductionist approach to atomic species, unless we abandon the persuasive intuition that the presence of an element in a substance ought to explain the properties of that substance. The ‘missing piece’ for explaining the properties of substances by way of their elemental constituents is the electronegativity values of participant atoms. But electronegativity is a strikingly disunified concept that appears distinctly unamenable to analysis by way of fundamental physical principles. Through evaluating the uncertain physical identity of electronegativity, as well as its widespread and indispensable epistemic utility in chemical practice, I argue that electronegativity provides compelling grounds to seriously consider emergence for atomic species.
Thermal and Microstructural Characterization of GRCop-84/In718 Bi-metallic Structures Additively Manufactured by Directed Energy Deposition
Authors: Wang Zexiao , O’Brien Nicholas , Jones Nicholas , Beuth Jack , Shen Sheng 
Published: December 2023

AbstractAs a nickel-based super alloy, Inconel 718 (In718) has gained attention in different industries due to its excellent mechanical behavior under elevated temperatures. Nevertheless, its low thermal conductivity limits its application in many fields, such as thermal energy conversion and heat dissipation. GRCop-84, in contrast, is a copper-based alloy with extremely high thermal conductivity. Making bi-metallic structures with GRCop-84 may expand the thermal-related applications of Inconel 718. In this study, we investigate the thermal properties of In718/GRCop-84 bi-metallic structures fabricated by the directed energy deposition (DED) technique with different process parameters of laser power and scanning velocity. The resulting microstructures were analyzed through scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS), while the frequency-domain thermoreflectance (FDTR) technique has been adopted to acquire the thermal properties. The melt pool thermal conductivities were 50 W/m K on single bead samples and 100 W/m K on single-layer pads, significantly lower than that of bulk GRCop-84. EDS analysis reveals large deviations from standard GRCop-84 compositions inside the melt pool.
Integrating single-cell transcriptomics with cellular phenotypes: cell morphology, Ca2+ imaging and electrophysiology
Authors: Camunas-Soler Joan 
Published: December 2023

AbstractI review recent technological advancements in coupling single-cell transcriptomics with cellular phenotypes including morphology, calcium signaling, and electrophysiology. Single-cell RNA sequencing (scRNAseq) has revolutionized cell type classifications by capturing the transcriptional diversity of cells. A new wave of methods to integrate scRNAseq and biophysical measurements is facilitating the linkage of transcriptomic data to cellular function, which provides physiological insight into cellular states. I briefly discuss critical factors of these phenotypical characterizations such as timescales, information content, and analytical tools. Dedicated sections focus on the integration with cell morphology, calcium imaging, and electrophysiology (patch-seq), emphasizing their complementary roles. I discuss their application in elucidating cellular states, refining cell type classifications, and uncovering functional differences in cell subtypes. To illustrate the practical applications and benefits of these methods, I highlight their use in tissues with excitable cell-types such as the brain, pancreatic islets, and the retina. The potential of combining functional phenotyping with spatial transcriptomics for a detailed mapping of cell phenotypes in situ is explored. Finally, I discuss open questions and future perspectives, emphasizing the need for a shift towards broader accessibility through increased throughput.
SOMP2B scientific nanosatellite of TU Dresden: operation and first results
Authors: Langer G. , Bärtling Y. , Schmiel T. 
Published: December 2023

AbstractThis paper presents the first in-orbit results of the modular two-unit (2U) nanosatellite SOMP2b, focusing on the satellite bus itself and its scientific payloads. Launched in January 2021, SOMP2b comprises an innovative highly integrated satellite design with a high payload capacity. It contains the in-situ measurement of atomic oxygen in the thermosphere (FIPEXnano), a thermoelectric generator to investigate waste heat recovery in satellites (TEGonSOMP) and a material experiment to study the behaviour of carbon nanotubes in a space environment (CiREX2). The commissioning of the satellite bus was, in most respects, successful. Despite manageable limitations in communication and attitude functions, the payloads TEGonSOMP and FIPEXnano were successfully commissioned. Regarding the failure of CiREX2, countermeasures in fthe orm of in-orbit software updates are being investigated at the time of this publication.
Euler–Lagrange–Herglotz equations on Lie algebroids
Authors: Anahory Simoes Alexandre , Colombo Leonardo , de León Manuel , Salgado Modesto , Souto Silvia 
Published: December 2023

AbstractWe introduce Euler–Lagrange–Herglotz equations on Lie algebroids. The methodology is to extend the Jacobi structure from$$TQ\times \mathbb {R}$$TQ×Rand$$T^{*}Q \times \mathbb {R}$$T∗Q×Rto$$A\times \mathbb {R}$$A×Rand$$A^{*}\times \mathbb {R}$$A∗×R, respectively, whereAis a Lie algebroid and$$A^{*}$$A∗carries the associated Poisson structure. We see that$$A^*\times \mathbb {R}$$A∗×Rpossesses a natural Jacobi structure from where we are able to model dissipative mechanical systems on Lie algebroids, generalizing previous models on$$TQ\times \mathbb {R}$$TQ×Rand introducing new ones as for instance for reduced systems on Lie algebras, semidirect products (action Lie algebroids) and Atiyah bundles.
Long-run real-time PCR analysis of repetitive nuclear elements as a novel tool for DNA damage quantification in single cells: an approach validated on mouse oocytes and fibroblasts
Authors: Kotarska Katarzyna , Gąsior Łukasz , Rudnicka Joanna , Polański Zbigniew 
Published: December 2023

AbstractSince DNA damage is of great importance in various biological processes, its rate is frequently assessed both in research studies and in medical diagnostics. The most precise methods of quantifying DNA damage are based on real-time PCR. However, in the conventional version, they require a large amount of genetic material and therefore their usefulness is limited to multicellular samples. Here, we present a novel approach to long-run real-time PCR-based DNA-damage quantification (L1-LORD-Q), which consists in amplification of long interspersed nuclear elements (L1) and allows for analysis of single-cell genomes. The L1-LORD-Q was compared with alternative methods of measuring DNA breaks (Bioanalyzer system, γ-H2AX foci staining), which confirmed its accuracy. Furthermore, it was demonstrated that the L1-LORD-Q is sensitive enough to distinguish between different levels of UV-induced DNA damage. The method was validated on mouse oocytes and fibroblasts, but the general idea is universal and can be applied to various types of cells and species.