bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol paper for the Vincular Project: a randomized controlled trial with changes in 24- hour movement behaviors targeting the reduce of depressive symptoms in adults
Authors: Bertuol Cecília , Alves Deborah Kazimoto , Duca Giovani Firpo Del 
Published: January 2024

Abstract
Background: A better understanding of how behavior change interventions work to reduce depressive symptoms, as well as their effects and potential mediators, is needed. This paper described the methods of the Vincular Project, an intervention based on Self-Determination Theory with changes in 24-hour movement behaviors to reduce depressive symptoms in Brazilian adults.
Methods: This is a randomized, controlled, blinded clinical trial with adults aged 20 to 59 years, of both sexes, with depressive symptoms. The sample was intentional and non-probabilistic and participants were allocated to a control group and an intervention group. The intervention was carried out twice a week, for 16 weeks and consisted of face-to-face and online meetings. The activities aimed to make participants more aware of their living and health conditions, exploring 24-hour movement behaviors, especially physical activity, and their relationships with depressive symptoms. The contents were different in each meeting and the activities were organized into four blocks, the first being contextualization, the second with general and specific guidelines on 24-hour movement behaviors, the third with opportunities to practice physical activity in different contexts and situations, and the fourth with strategies for maintaining healthy behaviors in the short and long term. Baseline (January 2022), post-intervention (May 2022), and maintenance (November 2022) evaluations included depressive symptoms as primary outcome, and 24-hour movement behaviors and basic psychological needs as secondary outcomes. The variables of autonomy, competence and relatedness were also tested as mediators related to the effectiveness of the intervention on depressive symptoms. Depressive symptoms were measured by the Patient Health Questionnaire-9 (PHQ-9), 24-hour movement behaviors by self-report and accelerometry, and basic psychological needs by the translated and adapted version of the Basic Psychological Needs in Exercise Scale (BPNES). To verify the effect of the intervention, per-protocol and intention-to-treat analyses will be conducted using Generalized Estimating Equations (GEE). Structural Equation Models (SEMs) will be employed in the mediation analysis. Discussion:The results of this trial will involve valuable information about the effect of a behavioral intervention to reduce depressive symptoms carried out in a middle-income country.
Trial registration: Brazilian Registry of Clinical Trials (ReBEC): RBR-7466htj, April, 17 2023. Retrospectively registered.
Optimization a method based on headspace-gas chromatography-ion mobility spectrometry for the rapid and visual analyzation of flavor compounds interaction in Baijiu
Authors: Wang Guangnan , Liu Feifei , Cheng Huan , Zheng Fuping , Ye Xingqian , Sun Baoguo 
Published: January 2024

Abstract
The flavor of Baijiu is not only determined by the individual flavors of the compounds but also by the combination of them. The exploration of the interaction effects between flavor compounds remains in the nascent stages. In this study, a method based on headspace-gas chromatography-ion mobility spectrometry has been proposed to swiftly elucidate the interactions among flavor compounds in Baijiu. To optimize the critical factors influencing headspace generation, namely, incubation time, sample quantity, injection volume, and alcohol content, we employ a Box-Behnken design integrated with Response Surface Methodology. Model solutions were created with 13 common flavor compounds typically found in Baijiu and varying concentrations of lactic acid, allowing researchers to evaluate the intensity of the interaction between lactic acid and these compounds by comparing the concentration of flavor compounds in the presence of different levels of lactic acid. The findings revealed that lactic acid had a strong correlation with the majority of the flavor compounds, and the disparities among the model solutions with flavor compounds augmented as the lactic acid content rose. This research presents a novel analytical approach, offering rapid insights into the correlation between flavor components in Baijiu and other complex food matrices.
Outcome of robot-assisted surgery for stage IA endometrial cancer compared to open and laparoscopic surgeries: A retrospective study at a single institution
Authors: Ikebuchi AI , Komatsu Hiroaki , Yamamoto Koji , Okawa Masayo , Hikino Kohei , Iida Yuki , Hosokawa Masayo , Sawada Mayumi , Kudo Akiko , Sato Shinya , Harada Tasuku , Taniguchi Fuminori 
Published: January 2024

Abstract
Background
Few studies have compared the efficacy of robot-assisted, laparoscopic, and open surgeries for endometrial cancer. When considering the position of robotic surgery in Japan, it was necessary to determine whether it was effective or not. We aimed to compare the efficacy and safety of these three types of surgeries for early-stage endometrial cancer.
Methods
In total, 175 patients with endometrial cancer of preoperative stage IA, who had undergone laparotomic (n=80), laparoscopic (n=40), or robot-assisted (n=55) modified radical hysterectomy at our hospital from 2010 to 2022, were included; surgical outcomes, perioperative complications, and prognoses were compared. Total operative and console times for robot-assisted surgery between patients who did or did not undergo pelvic lymphadenectomy were assessed.
Results
The robot-assisted group had the shortest total operative time. The estimated blood loss was lower in the laparoscopic and robot-assisted groups than in the laparotomy group. In advanced postoperative stage IA cases, there were no differences in progression-free and overall survival among the three groups. In the robot-assisted group, the operative time decreased as the number of operations increased; the learning curve was reached after 10 cases each of patients with and without pelvic lymphadenectomy. The frequency of perioperative complications of Clavien–Dindo classification Grade 1 or higher was the lowest in the robot-assisted group (p=0.02). There were no complications of Clavien–Dindo classification Grade 2 or higher in the robot-assisted group.
Conclusion
Robot-assisted surgery for stage IA endometrial cancer, a minimally invasive procedure, has fewer operative times and complications than those of laparoscopic and open surgeries in a single institution in JAPAN.
The Effect of Plate Location on Radial Nerve Palsy Recovery Time Associated with Humeral Shaft Fractures
Authors: Günsoy Zeki , Sayer Gökhan , Dinç Mustafa , Soydemir Ömer Cevdet , Oğuzkaya Sinan 
Published: January 2024

Abstract

BACKGROUND
This study aims to investigate the influence of plate placement on nerve regeneration in humerus fractures accompanied by radial nerve injury.
METHODS
A retrospective analysis was conducted on a cohort of 94 patients with humerus fractures and concomitant radial nerve injury treated between January 2018 and November 2022. After applying exclusion criteria, 31 patients were included in the study. Clinical outcomes were assessed by comparing demographic data, surgical duration, radial nerve recovery time, the Mayo Elbow Performance Score (MEPS), Disabilities of the Arm Shoulder and Hand (DASH), and the Medical Research Council (MRC) scale.
RESULTS
Two distinct groups were established: lateral plating and anteromedial (AM) plating. These groups demonstrated comparability regarding age, gender, and body mass index (BMI). No statistically significant differences were observed between the groups concerning MEPS and MRC. The AM plating group notably exhibited shorter surgical durations, faster recovery times, and lower DASH scores.
CONCLUSION
According to the findings of this investigation, in cases of humerus fractures accompanied by radial nerve injury, AM plating may be preferable over lateral plating due to its association with reduced surgical durations, expedited nerve recovery, and superior functional outcomes.
Robust Fully Explicit Method for Solving the Navier-Stokes Equations
Authors: Oguni Kenji , Hirobe Sayako 
Published: January 2024

Abstract
The motion of viscous fluids is described by the Navier-Stokes equations. The inherent nonlinearity in the Navier-Stokes equations prevents us from the analytic solutions. This paper introduces a robust fully explicit method for numerically solving the discretized Navier-Stokes equations, applicable to various flow types without tuning parameters or artificial models. The numerical analysis results demonstrating the stability and the robustness of the proposed fully explicit method imply the discovery of the rigorous spatial integration of the Navier-Stokes equations over the subdomain uniquely defined for the discrete sampling points in the analysis domain. We anticipate that our findings could serve as a milestone to the comprehensive resolution of the millennium problem regarding the Navier-Stokes equations.
Quantitative summarization of High-touch Fomites for Healthcare Associated Infection (HAI) Risks: a systematic review
Authors: Olufadewa Isaac Iyinoluwa , Latimer Harrison , West Hal , Chen Shi 
Published: January 2024

Abstract

Background
Nearly 700,000 people in the U.S. acquire healthcare associated infections (HAIs) annually, and the situation might have worsened during the COVID-19 pandemic. Evidence has shown that fomites, such as environmental surfaces and medical devices, play a critical role in the transmission of HAI. Our study systematically reviews findings from studies that provided quantitative evidence on the contact pattern and/or rank of high-touch surfaces (HTS).

Methods
We systematically searched 4 major databases (PubMed, Web of Science, CINAHL and Cochrane Database) for articles published before June 30, 2023 based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines (international prospective register of systematic reviews registration CRD42023408483). Relevant search terms we used, including Fomites AND Contact Pattern (eg high-touch OR mutual-touch) AND Healthcare Setting (eg ICU OR Emergency Department) AND HAI (eg Clostridiodes difficile). We also searched for relevant articles in the reference list.

Result
A total of 2,826 studies were screened across all four databases with 7 studies meeting the eligibility criteria. The fomite which was most frequently touched was the bed rail. Frequently touched surfaces are supply carts, bed surfaces, patient files/notes, medication carts, bedside tables, and Intravenous pump. Other frequently contacted fomites were vital sign monitors, phones, curtains, computer/computer keyboards, chair and sink surfaces, blood pressure cuffs, computer mouse and light switch. Common mutually touched fomites were bedside rail, patients’ body, patient file, bedside table and hand washing faucet handles. Only 2 studies utilized a covert observational technique, the other 5 applied either direct observation or did not state explicitly.

Conclusion
Our study provides empirical data which is important for the prioritization in cleaning and disinfection practices, development of HAI prevention and control protocols, and the optimization of cleaning and disinfection resources. We suggest that more rigorous studies quantifying high-touch fomites, especially those including detailed contact duration, sequence and temporal variations, be conducted.
The Prevalence, Predictors, and Knowledge, Attitudes, and Practices Concerning Percutaneous Exposure Incidents among Healthcare Workers and Students in Africa: A Narrative Review.
Authors: Aiseosa Osadolor , GE Ugwoke , OC Obazee 
Published: January 2024

Abstract
ABSTRACT

Introduction:Percutaneous exposure incidents (PEIs) encompass needlestick injuries, injuries involving sharp objects, and exposures of the skin and mucous membranes to potentially infectious blood, saliva, tissue, and other bodily fluids. The burden of PEIs among healthcare workers and students remains a challenge globally while newer predictors of PEIs continue to emerge.
Objective:This study is aimed at ascertaining the prevalence, predictors and level of knowledge, attitudes, and practices concerning PEIs among healthcare workers and students.
Methods:This review was conducted using a systematic literature search of the following databases and registers: PubMed, Directory of Open Access Journals, Research4life, ScienceDirect, Networked Digital Library of Theses and Dissertations, Open Access Theses and Dissertations, TROVE, Latin American and Caribbean Centre on Health Sciences Information, Scopus, The Cochrane Library, Cumulative Index of Nursing and Allied Health Literature [via EBSCOhost], Africa Journal Online, Google Scholar, and MedNar in December 2023. Observational studies, experimental studies, case-control studies, longitudinal studies, theses and dissertations were considered in these searches. A total of fifty-six studies and 16,607 respondents participated in the review.
Results:The annual prevalence of PEIs in Africa ranged from 18.7% to 83.3%, meanwhile, the lifetime prevalence varied between 15.6% and 90.3%. The overall annual and lifetime prevalences were 48.0% and 44.6% respectively. Notable predictors of PEI occurrence included needle recapping, female gender, increased workload, and lack of infection prevention and patient safety training. A majority of respondents exhibited good knowledge, positive attitudes and good practices concerning PEIs
Conclusions: The prevalence of PEIs is still high among African healthcare workers and students in the presence of a consistent emergence of novel predictors. The knowledge, attitudes, and practices of African healthcare workers and students are encouraging, however, the need for more investigations in this domain cannot be ruled out for a more holistic piece of evidence.
Assessment of the Knowledge, Attitudes, and Practices for Optimal Oral Health among Adults in Benin City, Nigeria.
Authors: Aiseosa Osadolor , CV Ugorji , JE Emajemite , OJ Ihwuwayovwe , IS Adolf , GE Ugwoke 
Published: January 2024

Abstract
Introduction: Oral health which is crucial for overall well-being, involves maintaining good oral hygiene to prevent diseases. Despite global progress, gaps persist, particularly in developing countries, leading to an increased prevalence of oral diseases. Factors such as oral health awareness, access, cultural beliefs, and dental phobia impact oral health. Similarly, oral health knowledge, attitudes, and practices have been reported to play vital roles.
Objective: To assess the knowledge, attitudes, and practices, related to the oral health of adults in Benin City, Edo State.
Methods: This was a cross-sectional study of adults presenting at a dental outreach programme in three conveniently selected local government areas (Ikpoba-Okha, Oredo, and Egor) of Benin City, Edo State. Data generated from this study was analysed using the IBM® SPSS® statistics version 25 software. Descriptive data were presented as frequencies and percentages; tables were utilized for clarity. The mean percentage of oral health knowledge, attitude, and practices were categorized as follows: poor (< 50.00%), fair (50.00% – 69.99%), and good (≥ 70.00%). The level of significance, α, was set at 0.05.
Results: A total of 198 respondents aged 18 – 74 were investigated while attending a dental outreach programme. The mean percentage of oral health knowledge, attitude, and practices among the respondents was 57.5%, 83.1%, and 55.0% respectively.
Conclusion: This study assessed respondents’ oral health knowledge, attitudes, and practices, revealing fair knowledge and practices but good attitudes. There are notable gaps, particularly in oral hygiene knowledge and practices. The positive attitudes recorded in the present study provide a scaffold for effective oral health promotion.
The analysis of the link between exchange rate and inflation: Evidence from quantile regression approach
Authors: Mansouri Zakaria , Liouaeddine Mariem , Laamire Jaouad 
Published: January 2024

Abstract
Given the impact of price hikes on the global economy and developing countries, this paper aims to determine the factors influencing overall food inflation in Morocco. We use quarterly data from The Central Bank of Morocco (BAM) and the Food and Agriculture Organization of the United Nations (FAO) to answer this question, using a quantile regression analysis. Our results suggest that the exchange rate exerts positive and statistically significant effects on overall food inflation. We also find that oil prices negatively affect food inflation, while gross domestic product and monetary policy do not affect overall food inflation. Ultimately, our results show that inflation in Morocco is predominantly imported.
Business-Processes in Economy as Reflection of Society Digitalization Processes
Authors: Panov A. V. 
Published: January 2024

Статья посвящена развитию цифрового пространства в мире, а также процессам, связанным с его становлением в качестве основного способа взаимодействия в современной экономике. Методологическую основу исследования составляют анализ статистических данных, аналитических материалов, исследований ряда научных публикаций по направлениям, законодательных актов, а также авторский материал. На основе данных Росстата составлен ряд выборок, который показывает текущее состояние и тенденции развития процессов цифровизации и информационных систем, их значение для бизнеса. Проанализированы данные по статистике распространения Интернета в домашних хозяйствах, проведено их сопоставление с данными по промышленности. Автором исследованы текущее состояние развития Интернета на территории РоссийскойФедерации, его распространение на основе статистики электронного обмена и взаимосвязь сети Интернет и торговли. Сделан вывод, что статистическая информация не показывает существенного развития новых технологических процессов внутри организаций. При этом отмечено значение психологического влияния материала на продукт, а также дана оценка воздействия цифровизации на экономику. Результаты исследования вносят вклад в развитие теории нематериальных ресурсов.Перенести в английский вариант The article deals with the development of digital space in the world and processes connected with its establishment as a key way of interaction in today’s economy. Methodological foundation of the research was formed by analysis of statistical data, analytical materials, investigating some academic publications, enactments and author’s material. On the basis of the Rosstat data a number of samples were prepared, which show the current condition and development trends of digitalization processes and information systems and their importance for business. The author studied statistical information about the Internet spread in households and compared it with data on industry. The current standing of the Internet on the territory of the Russian Federation was researched, as well as its spread using statistics of e-exchange and interconnection between the Internet and trade. The author came to the conclusion that statistics does not show serious development of new technological processes in organizations. At the same time he highlighted the importance of psychological impact of the material on the product and estimated the influence of digitalization on economy. Findings of the research can foster the development of intangible resource theory.
Network Pharmacology Study on the Underlying Mechanism of Danggui–Kushen Herb Pair in Adjuvant Chemotherapeutics against Breast Cancer
Authors: Hu Yijuan , He Jiaolong , Xu Yunling 
Published: January 2024

Background:
The Danggui–Kushen herb pair (DKHP) is a classic prescription that has
long been used in combination with chemotherapeutic drugs to improve the immune status of patients
with breast cancer (BC), however, the active components and the underlying pharmacological
mechanisms remain unclear. Therefore, this study aimed to elucidate the possible mechanism
of action of DKHP against BC-based comprehensive strategy combining network pharmacology,
molecular docking, and cellular experiments.

Methods:
The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform
was used to obtain the relevant compounds in DKHP. Genecards and the National Center for
Biotechnology Information databases were used to predict BC targets. Then, drug–compound–
target, and protein–protein interaction networks were constructed to forecast the promising protein
targets of DKHP and identify the primary interactions that occur between the protein targets and
compounds. Finally, the predicted candidate targets were validated using docking techniques and
in vitro experiments.

Results:
A total of 30 potential active compounds and 173 intersecting pharmacological targets
were identified in DKHP. Gene Ontology enrichment analysis revealed that the inflammatory response,
positive regulation of protein phosphorylation, and cellular response to lipopolysaccharide
were closely related to DKHP treatment in BC. Kyoto Encyclopedia of Genes and Genomes pathway
analysis suggested that the PI3K/AKT pathway may be crucial for DKHP intervention in BC.
Therefore, key targets could be AKT1, TP53, VEGR, CASP3, TNF, and IL6. Molecular docking
analysis suggested that hyperforin, kushenin, and kushenol T had good binding ability to Akt, p53,
and Caspase 3. The in vitro experiment showed that the DKHP extract promoted the apoptosis of
MCF-7 cells via the PI3K/Akt signaling pathway. These results corresponded to the predictions
produced using the network pharmacology approach.

Conclusion:
Hyperforin, kushenin, kushenol T, and other active compounds in DKHP can regulate
multiple signaling pathways and targets, such as AKT1, TP53, and CASP3, thereby playing preventive
and therapeutic roles in BC.
Novel Association of RAD54L Mutation with Müllerian Clear Cell
Carcinoma of the Male Urethra: New Insights Regarding the Molecular
Mechanisms of a Rare Tumour
Authors: Deng Huiyan , Ding Yan , Wang Zhiyu , Liang Xiangdong , Liu Yueping 
Published: January 2024

Introduction:
Müllerian clear cell carcinoma of the male urethra is similar to that of the
female genital tract in terms of morphology and immunohistochemical expression but is rarely observed in clinical practice.

Case Presentation:
Here, we report the case of a 65-year-old man diagnosed with Müllerian clear
cell carcinoma who harboured a mutation in RAD54L. This patient was diagnosed by electrocautery and ultimately underwent prostatectomy. After a six-month follow-up period, no signs of
recurrence or additional malignancy were found. Based on our analysis of the available literature,
it appears that Müllerian clear cell carcinoma with RAD54L mutation has not been reported until
now.

Conclusion:
This case enhances our knowledge of the molecular biology of Müllerian clear cell
carcinoma of the male urethra, which will help clinicians select optimal treatment options for this
rare cancer in patients with specific driver mutations.