bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of fintech adoption: evidence from SMEs in Indonesia
Authors: Saadah Kamalah , Setiawan Doddy 
Published: November 2023

PurposeThis study aims to explore the factors that determine the perceived benefits and the perceived risks of financial technology (fintech) and to evaluate the influence of perceived benefits, perceived risks and small and medium-sized enterprises’ (SMEs') trust to continue using fintech.Design/methodology/approachThis study involves SMEs in Indonesia. Non-probability with a convenience sampling technique was used in this study.FindingsConvenience and economic benefits can explain the perceived benefits. Operational risk is stated as a risk factor felt by the respondents. Furthermore, the perceived benefits have a positive effect and the perceived risks show a negative effect on trust. At the same time, the individuals’ intention to continue using fintech is determined by trust.Research limitations/implicationsBased on the theory of reasoned action (TRA), various benefits and risks of using fintech are used to build the construction of perceived benefits and perceived risk in building trust that will determine decision to continue using fintech.Practical implicationsThis research can provide advice to managers to develop efficient payment systems, lower payment fee and error-free transactions. In addition, the fintech management needs to understand the risks related to operational risks that are a challenge for the users to decide to use fintech so that a reliable mechanism for using fintech can be developed. Furthermore, it will be useful for fintech developing companies as a reference in knowing the factors that influence users in continuing to use fintech, this allows fintech developing companies in Indonesia will be even more developed and accelerate the achievement of the Sustainable Development Goals.Originality/valueTo the best of the authors’ knowledge, research on the factors that affect the trust of SMEs in adopting fintech has not been conducted. This study can be advantageous for fintech service companies and organizers in developing fintech strategies in terms of users who are involved in SMEs which is the population in Indonesia is enormous and has a significant role in the development of the country.
Privacy concerns in tourism: a systematic literature review using machine learning approach and bibliometric analysis
Authors: Sharma Hitesh , Srivastava Praveen Ranjan , Jasimuddin Sajjad M. , Zhang Zuopeng Justin , Jebabli Ikram 
Published: November 2023

PurposeThis study aims to provide a comprehensive analysis of the current privacy concerns in the tourism industry by uncovering the key factors leading to such concerns (i.e. smart public services, cyber security issues, consumer behaviour and governance). Using papers from multiple sources, the relationship between technology advancements and tourist’s privacy concerns has been established.Design/methodology/approachThis study adopted a machine learning-based systematic literature review approach to find out the clusters. The study analysed 68 papers using the topic modelling approach. A four-cluster solution was considered to be most representative of the extant literature identified using bibliographic coupling. Finally, content analysis of the selected literature has been performed.FindingsThis study identified four factors majorly leading to privacy concerns amid increasing technological advancements. Moreover, these factors were found to have a dyadic relationship with technological advancements. To everyone’s amazement, sustainable tourism was also found to have led to privacy concerns among tourists along with a lack of governance and cyber security issues. Furthermore, cluster-wise future research directions are provided based on the content analysis.Originality/valueThis study contributes to the literature by systematically reviewing and identifying the four dimensions leading to privacy concerns. To the best of the authors’ knowledge, the study done is the only attempt to synthesize the extant literature on tourists’ privacy concerns using an unbiased scientific approach.
Sound Change and Analogy, Again: Brugmann's Law and the Hunt For O‐Grades in Indo‐Iranian*
Authors: Grestenberger Laura 
Published: November 2023

AbstractThis article revisits the interaction between regular ‘Neogrammarian’ sound change (defined as a purely phonological process) and subsequent morphological change (especially changes subsumed under the term ‘analogy’) in the development of the outcomes of Brugmann's Law (BL) in Indo‐Iranian. The traditional formulation of BL states that Proto‐Indo‐European *o became Indo‐Iranian /ā/ in open syllables and /a/ elsewhere, positing a purely phonological context of application. Alternatively, Kiparsky (2010) has argued for a revised version of BL in which the accent and ablaut properties of the affected forms play a role, hence essentially for a synchronic morphophonological rule. I argue that this revised version fails both from the perspective of comparative reconstruction and as a synchronic rule based on a detailed study of the forms cited as evidence for the revised rule. Rather, in order to identify inherited *o in Indo‐Iranian the effects of the ‘blind’ Neogrammarian rule must be separated from the synchronic morphological rules of the attested languages. This paper thus makes a methodological contribution in defence of the Neogrammarian approach to sound change, but also an empirical contribution by showing that this approach, in combination with a strictly lexical definition of analogy, can account for some conspicuous exceptions to traditional BL.
‘A learner is like a snowflake, each unique’: Uncovering pre‐service language teachers' perceptions of differentiation relying on visualisations, metaphors and group discussions
Authors: Roiha Anssi , Heinonen Pilvi 
Published: November 2023

AbstractThis article examines pre‐service language teachers' perceptions of learning and teaching and how differentiation manifests itself in them. The 67 participants visualised ‘an ideal language learning situation’ and complemented a number of teaching‐related metaphors, for instance, ‘A teacher is like…’ and ‘A learner is like…’ in the first session of their pedagogical studies. Seven participants returned to reflect on these outputs in group discussions held at the end of their studies. The data were analysed qualitatively following thematic analysis. We identified some themes of differentiation already in the initial outputs, that is, visualisations and metaphors, such as teaching methods and learning environment. In particular, the metaphors contained references to the individuality and uniqueness of the pupils. In the group discussions, the participants further highlighted the importance of differentiation for instance through the themes of differentiation for high‐achieving pupils and the contradiction between ideal and practice. Based on the group discussions, the participants' understanding of differentiation expanded at least to some extent during their studies. Overall, the results suggest that the ideal of differentiation is present at some level when students enter their studies and that they are able to embrace it even more during their studies. Despite this, some participants still reflected rather limited views of differentiation, for instance, the focus on ability levels and textbook‐based learning. This implies that differentiation should be addressed more profoundly in pre‐service teacher education.
Global, regional, and national burden of tracheal, bronchus, and lung cancers attributable to high fasting plasma glucose: A systematic analysis of global burden of disease 2019
Authors: Wang Minmin , Liu Jingyi , Wang Jia , Jin Yinzi , Zheng Zhi‐Jie 
Published: November 2023

AbstractBackgroundTracheal, bronchus, and lung (TBL) cancer is the third most common and lethal type of cancer worldwide. Glucose metabolism disorders, as represented by high fasting plasma glucose (HFPG), increase the risk of development and worsen the prognosis of TBL cancer. This study aimed to evaluate the global disease burden of TBL cancer attributable to HFPG.MethodsThe TBL cancer burden attributable to HFPG was estimated based on a modeling strategy using the Global Burden of Disease Study 2019. The disease burden globally and by regions, countries, development levels, age groups, and sexes were also evaluated with the indicators of death, disability‐adjusted life years, years of life lost, and years lived with disability. The estimated annual percentage change (EAPC) was calculated by regression model to show the temporal trend.ResultsIn 2019, approximately 8% of the total TBL cancer burden was attributable to HFPG. The HFPG‐attributable TBL cancer burden increased globally from 1990 to 2019 with the EAPC of 0.98% per year. The burden was positively associated with social development levels, and the global burden was three times greater in men than in women. HFPG‐attributable TBL cancer burden increased with age and peaked at above 70 years of age.ConclusionsThe findings highlight the effect and burden of glucose disorders, as represented by HFPG on TBL cancer burden. Integrated cancer prevention and control measures are needed, with control of glucose disorders as one of the key elements.image
The migration of aquatic macrocrustaceans over an artificial barrier in the uThukela river, South Africa
Authors: Burnett Matthew J. , Van Zyl Bradley , Downs Colleen T. 
Published: November 2023

AbstractDiadromous macrocrustaceans need connectivity between the ocean, estuary and river to complete their life cycle. Instream barriers in lower reaches of rivers threaten upstream migrations of diadromous macrocrustaceans. Varuna litterata migrate upstream after a spawning event out at sea. These migration events have been poorly documented. We documented the presence V. litterata and Macrobrachium spp. at a vertical slot fishway and a rock ramp on the Lower Thukela River Bulk Water Supply Scheme Weir, KwaZulu‐Natal, South Africa, during 2021–2022. We found Macrobrachium spp. and V. litterata made use of the rock ramp. However, the vertical slot fishway did hinder the migration of V. litterata significantly, as found in other studies.
Endorobotic submucosal dissection of rectal lesions using the single port robot DaVinci‐SP: initial experience of the first 10 cases
Authors: Ozgur Ilker , Cheong Ju Yong , Liska David , Holubar Stefan , Valante Michael A. , Steele Scott R. , Gorgun Emre 
Published: November 2023

AbstractBackgroundEndoluminal surgery is increasingly recognized as a mode of treatment for colorectal neoplasms with the latest robotic single port platform Da Vinci‐SP (Intuitive Surgical, Sunnyvale) facilitating submucosal dissection of benign rectal neoplasm.MethodIn this study, we present our initial experience with endorobotic submucosal dissection in the management of benign rectal neoplasms using the Da Vinci‐SP (Intuitive Surgical, Sunnyvale) between 2020 and 2021. The primary endpoint was the successful completion of submucosal dissection.ResultsDuring the study period, 10 patients underwent endorobotic submucosal dissection for benign rectal neoplasms. The median age of the patients was 68 (range: 59–78) years, and the mean BMI was 29.38 (range: 22.9–38.5). The mean size of the lesion was 42.3 mm (range: 20‐65 mm) and was located 7.3 cm (mean) from the anal verge (range: 2–10 cm). The mean operative time was 91.3 minutes (range: 57–137 minutes). All 10 dissections were completed successfully en bloc. There were no intraoperative complications or mortality. All patients were discharged on the same day and commenced on a normal diet. Late bleeding was observed in one patient receiving anticoagulation, and one patient had urinary retention. Pathology revealed two adenocarcinomas, six tubulovillous adenomas, one tubular adenoma, and one sessile serrated adenoma. There was no recurrence in all other patients during the median follow‐up of 6 months (range: 4–16 months).ConclusionsEndorobotic submucosal dissection using a single‐port robotic platform is safe and feasible for benign rectal mucosal neoplasms. The semiflexible platform offers an alternative to endoscopic submucosal dissection with favourable outcomes.
Adrenal volumes in fetuses delivering prior to 32 weeks' gestation: An MRI pilot study
Authors: Hall Megan , Hutter Jana , Uus Alena , du Crest Elise , Egloff Alexia , Suff Natalie , Al Adnani Mudher , Seed Paul T. , Gibbons Deena , Deprez Maria , Tribe Rachel M. , Shennan Andrew , Rutherford Mary , Story Lisa 
Published: November 2023

AbstractIntroductionSpontaneous preterm birth prior to 32 weeks' gestation accounts for 1% of all deliveries and is associated with high rates of morbidity and mortality. A total of 70% are associated with chorioamnionitis which increases the incidence of morbidity, but for which there is no noninvasive antenatal test. Fetal adrenal glands produce cortisol and dehydroepiandosterone‐sulphate which upregulate prior to spontaneous preterm birth. Ultrasound suggests that adrenal volumes may increase prior to preterm birth, but studies are limited. This study aimed to: (i) demonstrate reproducibility of magnetic resonance imaging (MRI) derived adrenal volumetry; (ii) derive normal ranges of total adrenal volumes, and adrenal: body volume for normal; (iii) compare with those who have spontaneous very preterm birth; and (iv) correlate with histopathological chorioamnionitis.Material and methodsPatients at high risk of preterm birth prior to 32 weeks were prospectively recruited, and included if they did deliver prior to 32 weeks; a control group who delivered an uncomplicated pregnancy at term was also recruited. T2 weighted images of the entire uterus were obtained, and a deformable slice‐to‐volume method was used to reconstruct the fetal abdomen. Adrenal and body volumes were obtained via manual segmentation, and adrenal: body volume ratios generated. Normal ranges were created using control data. Differences between groups were investigated accounting for the effect of gestation by use of regression analysis. Placental histopathology was reviewed for pregnancies delivering preterm.ResultsA total of 56 controls and 26 cases were included in the analysis. Volumetry was consistent between observers. Adrenal volumes were not higher in the case group (p = 0.2); adrenal: body volume ratios were higher (p = 0.011), persisting in the presence of chorioamnionitis (p = 0.017). A cluster of three pairs of adrenal glands below the fifth centile were noted among the cases all of whom had a protracted period at risk of preterm birth prior to MRI.ConclusionsAdrenal: body volume ratios are significantly larger in fetuses who go on to deliver preterm than those delivering at term. Adrenal volumes were not significantly larger, we hypothesize that this could be due to an adrenal atrophy in fetuses with fulminating chorioamnionitis. A straightforward relationship of adrenal size being increased prior to preterm birth should not be assumed.
Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the SHINY study
Authors: Gao Liqin , Song Yanping , Sun Xiaodong , Zhang Junjun , Liu Yuling , Chen Youxin , Wu Zhifeng , Jian Ye , Liu Xiaoling , Lv Lin , Chen Shaojun , Wang Yu‐sheng , Chen Nan , Ke Xiao , Zhang Feng 
Published: November 2023

AbstractPurposeTo evaluate the safety and efficacy of intravitreal injections of 0.5 mg conbercept in patients with choroidal neovascularization secondary to pathological myopia (pmCNV).MethodsThe 177 pmCNV patients were randomly assigned in a 3:1 ratio to receive conbercept or sham injection, respectively. The conbercept group receive conbercept intravitreal injections administered on a pro re nata (PRN) basis after 3 monthly loading doses. The sham group received three consecutive monthly sham injections and then one conbercept injection followed by PRN conbercept intravitreal injections.ResultsAt month 3, the mean BCVA for the two groups were improved by 12.0 letters (conbercept group, from 54.05 letters to 66.05 letters) and 0.6 letters (sham group, from 49.77 letters to 50.33 letters), respectively (p < 0.001). The mean central retinal thickness (CRT) at month 3 in the two groups decreased 62.0 μm (conbercept group, from 348.90 μm to 286.18 μm) and 4.4 μm (sham group, from 347.86 μm to 343.47 μm) (p < 0.001). At month 9, the mean BCVA improved by 13.3 letters in the conbercept group and 11.3 letters in the sham group. The mean CRT decreased 73.6 μm in the conbercept group and 55.9 μm in the sham group (p < 0.001). The most common ocular adverse events were associated with intravitreal injections, such as conjunctival haemorrhage and increased intraocular pressure.ConclusionIntravitreal injections of 0.5 mg conbercept provided improvement in visual and anatomical outcomes in pmCNV patients with low rates of ocular and nonocular safety events.
From book to bedside? A critical perspective on the debate about “translational bioethics”
Authors: Kremling Alexander , Schildmann Jan , Mertz Marcel 
Published: November 2023

AbstractThe concept of “translational bioethics” has received considerable attention in recent years. Most publications draw an analogy to translational medicine and describe bioethical research that aims at implementing and evaluating ethical interventions. However, current accounts of translational bioethics are often rather vague and seem to differ with regard to conceptual and methodological assumptions. It is not clear and scarcely analyzed what exactly “translation” in the field of bioethics means, in particular regarding goals and processes so that it is justified to appeal to translational medicine. In this article, we thus explore possible analogies and disanalogies between translational medicine and translational bioethics to establish whether the often occurring reference to concepts of translational medicine in the field of bioethics can be justified by substantial analogies. We will first provide an account of different models of translational medicine. In a second step, we will propose an analytic definition that explicitly articulates the essential characteristics of “translational research” irrespective of the research field (i.e., biomedicine, bioethics). Subsequently, we will explore whether and in how far general characteristics and phases of translational research in medicine can be applied to translational research in bioethics. Based on our analyses, we will come to the skeptical conclusion that at present there are considerable conceptual disanalogies and unsolved conceptual problems that disallow using “translational bioethics” in a meaningful analogy to respective accounts in biomedicine. Nevertheless, we will demonstrate that some insights gained by the conceptual accounts of translational medicine can contribute to advance current research activities in bioethics.
Assisted suicide and the discrimination argument: Can people with mental illness fulfill beneficence‐ and autonomy‐based eligibility criteria?
Authors: Braun Esther , Scholten Matthé , Vollmann Jochen 
Published: November 2023

AbstractAccording to the “discrimination argument,” it would be discriminatory and hence impermissible to categorically exclude people with mental illness (PMI) from access to assisted suicide (AS) if AS is accessible to people with somatic illnesses. In objection to this, it could be argued that excluding PMI is not discriminatory, but rather based on their inability to meet certain eligibility criteria for AS. Which criteria are deemed necessary depends on the approach taken to justifying AS. In this article, we describe two distinct ethical approaches to justifying AS and the eligibility criteria they entail and examine whether PMI can fulfill these criteria. A widespread “joint” approach based on beneficence and autonomy assumes that AS is justified when it alleviates the severe and irremediable suffering of a person who autonomously requests AS. An alternative, exclusively autonomy‐based approach assumes that providing AS is justified when a person's request is autonomous, regardless of whether AS is in her best interests. The latter approach underlies an important judgment of the German Federal Constitutional Court from 2020. We argue that PMI can in principle fulfill both beneficence‐ and autonomy‐based eligibility criteria for AS, and that a blanket exclusion of all PMI from AS is thus discriminatory on either approach. However, depending on which approach is taken, there are differences regarding the subgroups of PMI that would be eligible for AS. Whether the exclusion of specific PMI is discriminatory therefore depends on how we understand and justify AS.
Transitioning from transrectal to transperineal prostate biopsy using a freehand cognitive approach
Authors: Honoré Alfred , Moen Christian Arvei , Juliebø‐Jones Patrick , Reisæter Lars Anders Rokne , Gravdal Karsten , Chaudhry Adeel Asghar , Rawal Ravi , Sandøy Andrine , Beisland Christian 
Published: November 2023

ObjectivesTo report a single‐centre experience of a complete transition from transrectal (TR) to transperineal (TP) prostate biopsy under local anaesthesia using a freehand cognitive coaxial approach and without use of antibiotic prophylaxis.Patients and MethodsAnalysis was performed of a prospective database of patients undergoing prostate biopsy performed by four surgeons between 1 June 2018 and 31 May 2022. Outcomes of interest were complications, cancer detection rate, inter‐operator reliability, and tolerability.ResultsOverall, 1915 patients underwent 2337 separate prostate biopsy sessions. Only 2.4% patients in the TP group received antibiotic prophylaxis, while 100% received antibiotics in the TR group. The complication rate was significantly lower in the TP group compared to the TR group (0.3% vs 5.0%, P < 0.001). In contrast to the TR group, there were no cases of urosepsis or admissions to intensive care in the TP group. The total cancer detection rate by TP biopsy was 70% and the overall pathology detection rate was 88.4%. There was no difference in cancer or pathology detection between operators. A stable level of cancer detection was reached early on for both Prostate Imaging‐Reporting and Data System 4 and 5 lesions. All cases performed were performed successfully without need for early termination.ConclusionImplementing a complete transition from TR to TP biopsy can result in a significant reduction in complications and hospital re‐admissions. A cognitive freehand coaxial technique is well tolerated by patients and achieves a high cancer detection rate.
ZYZ384 suppresses the growth of EGFR‐mutant non‐small cell lung cancer by activating JNK/MAPK signaling pathway
Authors: Nie Xiao‐Wen , Nasim Ali Adnan , Yao Xiao‐Jun , Fan Xing‐Xing 
Published: November 2023

AbstractThe emergency of tyrosine kinase inhibitors has remarkably enhanced the clinical outcomes of cancer therapy, especially the use of EGFR inhibitors for non‐small cell lung cancer (NSCLC). However, acquired resistance is inevitable after 8–12 months treatment. New agents or treatments are urgently required to resolve this problem. In this study, we identified that compound ZYZ384 can selectively inhibit the growth of gefitinib‐resistant (G‐R) lung cancer cells, without affecting that of normal lung epithelial cells. ZYZ384 induced G2 arrest in G‐R NSCLC cells, decreasing the expression of Cyclin B1 and increasing the expression of P21. Meanwhile, ZYZ384 also induced apoptosis in NSCLC cells and correspondingly increased the expression of cleaved Caspase 3, 8, and 9 proteins. The expression of p‐JNK, p‐P38, and p‐ERK were also increased in H1975 NSCLC cells treated with ZYZ384. Finally, we observed that the JNK inhibitor effectively reversed the pro‐apoptotic effect of ZYZ384. In conclusion, ZYZ384 is a potential therapeutic agent to inhibit the growth of NSCLCs with EGFR mutations through activating JNK, which will help the development of related anticancer drugs.