bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nodular pyogranulomatous panniculitis due to Leishmania infantum infection in a domestic ferret (Mustela putorius furo)
Authors: Giner Jacobo , Jiménez Jordi , Gómez Alex , Rodríguez-Largo Ana , Juan-Sallés Carles , Riera Cristina , Fisa Roser , Villanueva-Saz Sergio 
Published: December 2023

AbstractLeishmaniosis is a vector-borne disease caused by different Leishmania species and transmitted by phlebotomine sand flies under natural conditions in Europe. Scientific information related to Leishmania infantum in dogs is extensive, where less information is available in cats and other companion animals. Recently, first clinical cases of L.infantum infection in domestic ferrrets (Mustela putorius furo) have been described. However, clinical information on leishmaniosis in this species is limited A 15-month-old male neutered domestic ferret was presented with chronic weight loss and the presence of coalescent, erythematous and firm subcutaneous nodules in the ventral abdominal subcutis. A fine-needle aspiration of these nodules was performed and the cytological examination revealed a granulomatous inflammation with the presence of macrophages contained a number of oval organisms with an eccentric nucleus and pale cytoplasm, compatible with Leishmania spp. amastigotes compatible with Leishmania spp. amastigotes. The nodules were surgically excised and histological examination showed a severe multifocal pyogranulomatous panniculitis. Specific immunohistochemistry and qPCR for L. infantum from excised nodules were positive. Additionally, L. infantum was cultured and isolated from the nodules by a fine-needle aspiration. An in-house Western Blot test for L. infantum was performed in serum sample and a positive result was obtained. This is the first reported case of nodular pyogranulomatous panniculitis due to L. infantum infection in a domestic ferret. Further studies are necessary to determine the relevance of domestic ferrets in the transmission of leishmaniosis. The description of new clinical forms of the disease is important as it can assist veterinarians in identifying these new clinical presentations.
Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-inflammatory Signalling Cues and Inhibit Phagocytosis
Authors: Regan Philip , Hole Katriona L. , Sero Julia , Williams Robert J. 
Published: December 2023

AbstractMicroglia are crucial players in the pathogenesis of late-onset Alzheimer’s disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiveness, promote amyloid β (Aβ) clearance, disrupt plaque formation, or dampen excessive inflammation has therapeutic potential. Bioavailable flavonoids, such as the flavan 3-ols, are of interest due to their antioxidant, metal chelating, signalling, and anti-inflammatory potential. Primary microglia were treated with a series of structurally related flavanol 3-ols to assess effects on phagocytosis, cytokine release, and transcriptional responses by RNA sequencing. Data indicated that the extent of hydroxylation and the presence of the galloyl moiety were strong determinants of flavan 3-ol activity. Epigallocatechin gallate (EGCG) was the most effective flavan-3-ol tested and strongly inhibited phagocytosis of Aβ independent of any metal chelating properties, suggesting a more direct modulation of microglia responsiveness. EGCG was broadly anti-inflammatory, reducing cytokine release and downregulating transcription, particularly of components of the microglia extracellular matrix such as MMP3 and SerpinB2. Collectively, this brings new insight into the actions of flavonoids on microglial responsiveness with potential implications for the therapeutic use of EGCG and structurally related flavanol-3-ols in AD.
A twenty-year bibliometric analysis on the relationship between complicated grief and attachment
Authors: Ribera-Asensi Olga , Valero-Moreno Selene , Pérez-Marín Marián 
Published: December 2023

AbstractAttachment theory is a key paradigm for understanding individual differences for the elaboration of the grieving processes, however limited attempts to systematically synthesize are found on the literature. Our aim is to conduct a bibliometric analysis about the relationship between complicated grief and attachment over the past twenty years. A bibliographic search was made in the Core Collection of Web of Science, the bibliometric analysis was performed using the software Hiscite version 2010.12.6, and VosViewer were used for the construction of bibliometric maps. Results show 276 publications from 2003 until 2023 from 789 authors, published in 143 scientific journals. The field presents a regular increase and sustained number of publications. The topics most researched were bereavement, complicated grief and attachment, and since 2018 has been increased interest in prolonged grief disorder. In conclusion, this bibliometric analysis contributes to the understanding of the current state of this topic and its evolution, being relevant to consider attachment style in bereavement interventions.
Costly effective bioleaching of valuable metals from low grade ore using Aspergillus nidulans
Authors: Ahmed B. M. , Mohammed A. A. , Kawady N. A. , Elaasy I. E. , Soliman E. R. S. 
Published: December 2023

AbstractThis research investigated the feasibility of employing organic acids, like citric acid, produced by Aspergillus nidulans MT355567 in a bioleaching process to recover uranium (U) from a low-grade rock sample. The optimal conditions for fungal growth and maximum citric acid (CA) synthesis across three distinct media were determined. The maximum citric acid concentration was produced on medium made from wheat bran (83%) and tea waste (77%). An investigation was carried out to see how citric acid and, by consequence, uranium bioleaching affinity, were affected by varying carbon sources, nitrogen sources, pH, temperature, incubation period, ore particle size, and the solid–liquid ratio. At 25 °C and a pH of 5.0, media containing 100 g/L of sucrose as a carbon source and peptone as a nitrogen source made the highest yield of citric acid and U bioleaching. Higher U bioleaching was achieved with ore particles 0.075 mm at a ratio of 2 g/L after only 30 min of contact with the fungal filtrate. Iron interference has a negative impact on uranium extraction. Interestingly, none of the conditions applied to enhance CA synthesis and U-bioleaching caused iron (Fe) dissolution. Based on these findings, it appears that bioleaching using A. nidulans MT355567 metabolic products is a promising economic and ecofriendly technology for extracting uranium from low-grade ore that might be adopted on a pilot scale.
Graphical abstract
summarizing the experimental workflow for bioleaching of uranium from low-grade ore using citric acid produced by Aspergillus nidulans. The process involved optimizing A. nidulans growth and citric acid biosynthesis, evaluating factors influencing bioleaching activity of the acid metabolite solutions, and finally applying the optimized conditions to bioleach uranium from the ore sample. The schematic illustrates the key steps and the optimal condition for Aspergillus nidulans growth medium preparation using agricultural wastes, downstream application of metabolite synthesized for uranium bioleaching
Two material removal modes in chemical mechanical polishing: mechanical plowing vs. chemical bonding
Authors: Wu Yuan , Jiang Liang , Li Wenhui , Zheng Jiaxin , Chen Yushan , Qian Linmao 
Published: December 2023

AbstractWith the rapid development of semiconductors, the number of materials needed to be polished sharply increases. The material properties vary significantly, posing challenges to chemical mechanical polishing (CMP). Accordingly, the study aimed to classify the material removal mechanism. Based on the CMP and atomic force microscopy results, the six representative metals can be preliminarily classified into two groups, presumably due to different material removal modes. From the tribology perspective, the first group of Cu, Co, and Ni may mainly rely on the mechanical plowing effect. After adding H2O2, corrosion can be first enhanced and then suppressed, affecting the surface mechanical strength. Consequently, the material removal rate (MRR) and the surface roughness increase and decrease. By comparison, the second group of Ta, Ru, and Ti may primarily depend on the chemical bonding effect. Adding H2O2 can promote oxidation, increasing interfacial chemical bonds. Therefore, the MRR increases, and the surface roughness decreases and levels off. In addition, CMP can be regulated by tuning the synergistic effect of oxidation, complexation, and dissolution for mechanical plowing, while tuning the synergistic effect of oxidation and ionic strength for chemical bonding. The findings provide mechanistic insight into the material removal mechanism in CMP.
The Academic Medicine and Leadership Track for Medical Students
Authors: Glaser Kelli , McEchron Matthew , Jensen Clyde , Park David 
Published: December 2023

AbstractPhysicians are expected to be educators and leaders, but few medical schools offer dedicated coursework or training to prepare medical students to meet those expectations. Since 2018, Rocky Vista University College of Osteopathic Medicine has offered a longitudinal Academic Medicine and Leadership (AML) Track in which medical students acquire knowledge and develop skills for academic medicine and leadership that will enhance their ability to become effective educators and leaders in their clinics, hospitals, professional associations, communities, and affiliated medical schools. This paper describes the novel AML Track, its learning activities, and some of its emerging outcomes.
Spatial-temporal episodic memory modeling for ADLs: encoding, retrieval, and prediction
Authors: Song Xinjing , Wang Di , Quek Chai , Tan Ah-Hwee , Wang Yanjiang 
Published: December 2023

AbstractActivities of daily living (ADLs) relate to people’s daily self-care activities, which reflect their living habits and lifestyle. A prior study presented a neural network model called STADLART for ADL routine learning. In this paper, we propose a cognitive model named Spatial-Temporal Episodic Memory for ADL (STEM-ADL), which extends STADLART to encode event sequences in the form of distributed episodic memory patterns. Specifically, STEM-ADL encodes each ADL and its associated contextual information as an event pattern and encodes all events in a day as an episode pattern. By explicitly encoding the temporal characteristics of events as activity gradient patterns, STEM-ADL can be suitably employed for activity prediction tasks. In addition, STEM-ADL can predict both the ADL type and starting time of the subsequent event in one shot. A series of experiments are carried out on two real-world ADL data sets: Orange4Home and OrdonezB, to estimate the efficacy of STEM-ADL. The experimental results indicate that STEM-ADL is remarkably robust in event retrieval using incomplete or noisy retrieval cues. Moreover, STEM-ADL outperforms STADLART and other state-of-the-art models in ADL retrieval and subsequent event prediction tasks. STEM-ADL thus offers a vast potential to be deployed in real-life healthcare applications for ADL monitoring and lifestyle recommendation.
An improved DeepLabv3+ lightweight network for remote-sensing image semantic segmentation
Authors: Chen Hui , Qin Yuanshou , Liu Xinyuan , Wang Haitao , Zhao Jinling 
Published: December 2023

AbstractTo improve the accuracy of remote-sensing image semantic segmentation in complex scenario, an improved DeepLabv3+ lightweight neural network is proposed. Specifically, the lightweight network MobileNetv2 is used as the backbone network. In atrous spatial pyramid pooling (ASPP), to alleviate the gridding effect, the Dilated Convolution in original DeepLabv3+ network is replaced with the Hybrid Dilated Convolution (HDC) module. In addition, the traditional spatial mean pooling is replaced by the strip pooling module (SPN) to improve the local segmentation effect. In the decoder, to obtain the rich low-level target edge information, the ResNet50 residual network is added after the low-level feature fusion. To enhance the shallow semantic information, the efficient and lightweight Normalization-based Attention Module (NAM) is added to capture the feature information of small target objects. The results show that, under the INRIA Aerial Image Dataset and same parameter setting, the Mean Pixel Accuracy (MPA) and Mean Intersection over Union (MIoU) are generally best than DeepLabv3+ , U-Net, and PSP-Net, which are respectively improved by 1.22%, − 0.22%, and 2.22% and 2.17%, 1.35%, and 3.42%. Our proposed method has also a good performance on the small object segmentation and multi-object segmentation. What’s more, it significantly converges faster with fewer model parameters and stronger computing power while ensuring the segmentation effect. It is proved to be robust and can provide a methodological reference for high-precision remote-sensing image semantic segmentation.
Users’ Experiences with Web-Based Mental Health App During COVID-19
Authors: Koushkaki Sara Rahmanian , Banta Jim E. , Heilemann MarySue V. , Grohar Albin H. , Chung Kyusuk , Wells Kenneth 
Published: December 2023

AbstractThe COVID-19 pandemic has had a significant impact on individuals, families, and communities, leading to increased stress, anxiety, and mental health issues. To address these needs, Together for Wellness/Juntos por Nuestro Bienestar (T4W/Juntos), a website providing mental health resources, was created. This study aims to understand the experiences of users of the T4W/Juntos website, to learn about the benefits of the website for its users during the pandemic, and to identify areas for improvement. A thematic analysis was conducted with answers given by 199 participants who responded to at least one of six open-ended questions that were included with other close-ended questions (reported elsewhere) in an electronically administered survey. The open-ended survey questions were developed with input from diverse stakeholders, including under-resourced populations. The sample was recruited through partnerships with 11 state-wide agencies. Five main themes were identified from analysis of the data. The major themes were (1) Disruptions and Challenges Experienced During the COVID-19 Pandemic, (2) Benefiting from an Accessible Website, and (3) Wanting Access to Additional Resources. The University of California, Los Angeles (UCLA), Institutional Review Board (IRB) for Human Subjects approved the study, and participants provided informed consent. The website provided access to resource links that brought needed information, a sense of empowerment, and support for individuals dealing with mental health issues related to the pandemic. Participants highly recommended the website to others. However, they also suggested improvements such as more specific resources and additional languages.
A computational study on efficient yield surface calibrations using a crystal plasticity spectral solver
Authors: Aria Arash Imani , Mánik Tomas , Holmedal Bjørn , Marthinsen Knut 
Published: December 2023

AbstractA computational framework is presented, capable of calculating virtual loads using the spectral solver in the DAMASK software for crystal plasticity simulations in desired stress directions. Calculations are used for the calibration of yield surfaces. The required spatial resolution is assessed based on a comparison with the previously published crystal plasticity finite-element method (CPFEM) and experimental results for three different aluminum alloys (AA1050, AA3103O, and AA3103H18) with 1000 and 2500 grains in a representative volume element. The results of the crystal plasticity fast Fourier transform (CPFFT) method agree well with CPFEM. The elongated grain morphology of the AA3103H18 alloy was found to have a small effect on predicted anisotropy. An analysis was made of how many tests are required for proper calibration of the Yld2004-18p orthotropic yield surface. It was found that 32 virtual tests, along either uniformly distributed strain rate or stress directions but obeying the orthotropic symmetry of the Yld2004-18p yield surface, make a good compromise between accuracy and computation time. Randomly chosen directions have a significantly larger error and require more virtual tests for a similarly good calibration of the yield surface. Since a preselected set of strain–rate directions does not require extra iterations, it is the preferred choice for the calibration of the full stress-based Yld2004-18p.
A chromosome-level genome of electric catfish (Malapterurus electricus) provided new insights into order Siluriformes evolution
Authors: Liu Meiru , Song Yue , Zhang Suyu , Yu Lili , Yuan Zengbao , Yang Hengjia , Zhang Mengqi , Zhou Zhuocheng , Seim Inge , Liu Shanshan , Fan Guangyi , Yang Huanming 
Published: December 2023

AbstractThe electric catfish (Malapterurus electricus), belonging to the family Malapteruridae, order Siluriformes (Actinopterygii: Ostariophysi), is one of the six branches that has independently evolved electrical organs. We assembled a 796.75 Mb M. electricus genome and anchored 88.72% sequences into 28 chromosomes. Gene family analysis revealed 295 expanded gene families that were enriched on functions related to glutamate receptors. Convergent evolutionary analyses of electric organs among different lineage of electric fishes further revealed that the coding gene of rho guanine nucleotide exchange factor 4-like (arhgef4), which is associated with G-protein coupled receptor (GPCR) signaling pathway, underwent adaptive parallel evolution. Gene identification suggests visual degradation in catfishes, and an important role for taste in environmental adaptation. Our findings fill in the genomic data for a branch of electric fish and provide a relevant genetic basis for the adaptive evolution of Siluriformes.
On the reflexivity properties of Banach bundles and Banach modules
Authors: Lučić Milica , Pasqualetto Enrico , Vojnović Ivana 
Published: December 2023

AbstractIn this paper, we investigate some reflexivity-type properties of separable measurable Banach bundles over a $$\sigma $$
σ
-finite measure space. Our two main results are the following:

The fibers of a bundle are uniformly convex (with a common modulus of convexity) if and only if the space of its $$L^p$$

L
p

-sections is uniformly convex for every $$p\in (1,\infty )$$

p
∈
(
1
,
∞
)

.

The fibers of a bundle are reflexive if and only if the space of its $$L^p$$

L
p

-sections is reflexive for every $$p\in (1,\infty )$$

p
∈
(
1
,
∞
)

.

They generalise well-known results for Lebesgue–Bochner spaces.
Evaluation of lead tolerance and biosorption characteristics of fungi from dumpsite soils
Authors: Titilawo Mobolaji Adenike , Ajani Temitope Fasunloye , Adedapo Suliyat Adeola , Akinleye Grace Oluwabusola , Ogunlana Olafunke Esther , Aderibigbe Deborah 
Published: December 2023

AbstractLead (Pb) pollution is a major concern in many developing nations of the world. Hence, there is a need for the development of an environmentally safe and cost-effective method for the clean-up of contaminated environments. The present study investigated the tolerance of presumptively identified fungal species isolated from 5 different dumpsite soils to Pb concentrations 200, 400, 600, 800, 1000, 1500, 5000, and 10000 mg/L. The identity of strains exhibiting outstanding tolerance was confirmed using molecular technique, and their biosorption capacity at 10000 mg/L was evaluated. FTIR and SEM analyses were performed on the Pb2+ untreated and treated fungal biomasses. A total of 17 fungal isolates belonging to the genera Aspergillus Alternaria, Chrysosporium, and Penicillium were obtained. All the fungi were resistant to the test concentrations of Pb2+ except Chrysosporium sp. (at 5000 mg/L and 10000 mg/L) and Alternaria sp. (at 1500 mg/L, 5000 mg/L, and 10000 mg/L). Four isolates molecularly identified as A. awamori OP341445 and OP341446 and A. niger OP342447 and OP341448 recorded outstanding tolerance (> 1). Biosorption capacity was at its peak on day 5 except in OP34148, day 10 with a value of 97.82 mg/g. The Pb2+ removal rate was at equilibrium on day 5 (≈86%) except for OP41447 and OP41448 (≈87%) on day 15. FTIR analysis reveals the involvement of functional groups O-H, C-H, N-H, O=C=O, C≡C, N=C=S, C=C, N-O, C-N, and S=O in the biosorption process. SEM showed distortion in the cellular structure of the fungi. These results indicated the lead remediation potential of the fungal strains.
Aristotle's Ontology of Artefacts
Authors: Papandreou Marilù 
Published: December 2023

It is commonly believed that Aristotle merely uses artefacts as examples or analogical cases. This book, however, shows that Aristotle gives a specific, coherent account of artefacts that in various ways owes much to Plato. Moreover, it proposes a new, definitive solution to the problem of artefacts' substantiality, which comprises two controversial positions: (i) that Aristotle holds a binary view of substantiality according to which artefacts are not substances at all; (ii) that artefacts fail to be substances because they exhibit less of a unity than natural wholes. Finally, responding to the contemporary debate on ordinary objects, the book identifies the main propositions for an ontology of artefacts that aspires to use Aristotle as its authority and can serve as a guideline for current metaphysical discussions. This title is part of the Flip it Open Programme and may also be available Open Access. Check our website Cambridge Core for details.
Effectiveness of multimodal participant recruitment in SPARK, a large, online longitudinal research study of autism
Authors: Daniels Amy M. , Law J. Kiely , Green Snyder LeeAnne , Diehl Katharine , Goin-Kochel Robin P. , Feliciano Pamela , Chung Wendy K. ,   SPARK Consortium
Published: December 2023

AbstractBackground:SPARK launched in 2016 to build a US cohort of autistic individuals and their family members. Enrollment includes online consent to share data and optional consent to provide saliva for genomic analysis. SPARK’s recruitment strategies include social media and support of a nation-wide network of clinical sites. This study evaluates SPARK’s recruitment strategies to enroll a core study population.Methods:Individuals who joined between January 31, 2018, and May 29, 2019 were included in the analysis. Data include sociodemographic characteristics, clinical site referral, the website URL used to join, how the participant heard about SPARK, enrollment completion (online registration, study consents, and returning saliva sample), and completion of the baseline questionnaire. Logistic regressions were performed to evaluate the odds of core participant status (completing enrollment and baseline questionnaire) by recruitment strategy.Results:In total, 31,715 individuals joined during the study period, including 40% through a clinical site. Overall, 88% completed online registration, 46% returned saliva, and 38% were core participants. Those referred by a clinical site were almost twice as likely to be core participants. Those who directly visited the SPARK website or performed a Google search were more likely to be core participants than those who joined through social media.Discussion:Being a core participant may be associated with the “personal” connection and support provided by a clinical site and/or site staff, as well as greater motivation to seek research opportunities. Findings from this study underscore the value of adopting a multimodal recruitment approach that combines social media and a physical presence.