bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of population structure in the estimation of recent historical effective population size by the software GONE
Authors: Novo Irene , Ordás Pilar , Moraga Natalia , Santiago Enrique , Quesada Humberto , Caballero Armando 
Published: December 2023

Abstract
Background
Effective population size (Ne) is a crucial parameter in conservation genetics and animal breeding. A recent method, implemented by the software GONE, has been shown to be rather accurate in estimating recent historical changes in Ne from a single sample of individuals. However, GONE estimations assume that the population being studied has remained isolated for a period of time, that is, without migration or confluence of other populations. If this occurs, the estimates of Ne can be heavily biased. In this paper, we evaluate the impact of migration and admixture on the estimates of historical Ne provided by GONE through a series of computer simulations considering several scenarios: (a) the mixture of two or more ancestral populations; (b) subpopulations that continuously exchange individuals through migration; (c) populations receiving migrants from a large source; and (d) populations with balanced systems of chromosomal inversions, which also generate genetic structure.

Results
Our results indicate that the estimates of historical Ne provided by GONE may be substantially biased when there has been a recent mixture of populations that were previously separated for a long period of time. Similarly, biases may occur when the rate of continued migration between populations is low, or when chromosomal inversions are present at high frequencies. However, some biases due to population structuring can be eliminated by conducting population structure analyses and restricting the estimation to the differentiated groups. In addition, disregarding the genomic regions that are involved in inversions can also remove biases in the estimates of Ne.

Conclusions
Different kinds of deviations from isolation and panmixia of the populations can generate biases in the recent historical estimates of Ne. Therefore, estimation of past demography could benefit from performing population structure analyses beforehand, by mitigating the impact of these biases on historical Ne estimates.
A survey on the current status of Helicobacter pylori infection in households in Hainan Province, China
Authors: Liu Danni , Pan Jing , Chen Zhengyi , Li Sailian , Ma Jiamei , Xiao Yening , Wang Danhong , Mu Ganggang , Lin Ya , Li Juyuan , Chen Zhai , Huang Xiaoxi 
Published: December 2023

Abstract
Objective
This study aims to assess the prevalence of Helicobacter pylori (Hp) infection at the household level in Hainan Province in China and identify the factors that contribute to its spread. The findings of this study have significant implications for public health prevention strategies in the Hainan region.

Methods
A total of 421 families, comprising 1355 individuals, were tested for Hp infection across five cities in Hainan Province between July 2021 and April 2022. The study utilized questionnaires that included questions about personal characteristics, household shared lifestyle and dietary habits, and potential pathways of Hp infection in children to identify potential factors linked to household Hp infection and transmission patterns.

Results
The prevalence of Hp infection on an individual basis was 46.72% (629/1355), with age ≥ 20 years, being married and having junior secondary education and above as risk factors for Hp infection. The prevalence of Hp infection in households was 80.29% (338/421), household size of 5, 6 and above were risk factors for Hp infection with Odds Ratios (ORs) of 4.09 (1.17–14.33) and 15.19 (2.01–114.73), respectively, household income ≥ 100,000 yuan and drinking boiled water from a tap source were protective factors for Hp infection with ORs of 0.52 (0.31–0.89) and 0.51 (0.28–0.95), respectively. The prevalence of Hp infection among minors in the household was 24.89% (58/233), with paternal infection and maternal infection as risk factors for child infection, with ORs of 2.93 (1.29–6.62) and 2.51 (1.07–5.89), respectively.

Conclusion
Hp infection was prevalent among Hainan families, and interaction with infected family members may be the primary cause of transmission.
Effect of Helicobacter pylori eradication evaluated using magnifying endoscopy with narrow-band imaging in mixed-type early gastric Cancer
Authors: Tokai Yoshitaka , Horiuchi Yusuke , Yamamoto Noriko , Namikawa Ken , Yoshimizu Shoichi , Ishiyama Akiyoshi , Yoshio Toshiyuki , Hirasawa Toshiaki , Fujisaki Junko 
Published: December 2023

Abstract
Background
The effect of Helicobacter pylori (H.pylori) eradication therapy on mixed-histological-type gastric cancer remains unclear. This study aimed to clarify the effect of H. pylori eradication therapy on mixed-histological-type early gastric cancer using endoscopic and histological findings.

Methods
This single-center, retrospective study included patients with mixed-histological-type gastric cancer who underwent endoscopic submucosal dissection at the Cancer Institute Hospital. We compared detailed magnifying endoscopy with narrow-band imaging findings between eradicated and non-eradicated groups of patients with differentiated-type- and undifferentiated-type-predominant cancers. Subsequently, we performed histological evaluations of the non-cancerous epithelium covering differentiated-type components.

Results
A total of 124 patients with mixed-type early gastric cancer were enrolled (eradicated group: 62 differentiated-type-predominant cancer patients and 8 undifferentiated-type-predominant cancer patients; non-eradication group: 40 differentiated-type-predominant cancer patients and 14 undifferentiated-type-predominant cancer patients). Regarding differentiated-type-predominant cancer, differentiated-type findings were detected in all patients in eradicated and non-eradicated groups. The difference in the detection rate of undifferentiated-type findings between both groups was not significant in differentiated-type-predominant cancer patients. In differentiated-type-predominant cancers, the percentage of non-cancerous epithelium covering differentiated-type components was higher in the eradicated group than in the non-eradicated group (median: 60% vs. 40%, p < 0.001).

Conclusions
Although the pathological findings of differentiated-type-predominant cancer were affected by H. pylori eradication, eradication did not affect the diagnosis of differentiated-type-predominant early gastric cancer using magnifying endoscopy with narrow-band imaging. ME-NBI is useful for the early detection of D-MIX EGCs and diagnosis of histological types during endoscopy, regardless of whether H. pylori eradication therapy has been administered.
Paranasal sinus angiosarcoma with facial paralysis as a novel manifestation: a case report and literature review
Authors: Chai Chengcheng , Feng Xiaocong , Li Kai , Yan Zhaoxian , Tan Shuyi , Weng Jin , Huang Fan , Huang Jianpeng , Zhu Xinru , Zhuo Xuehui , Chen Hai 
Published: December 2023

Abstract
Background
Paranasal sinus angiosarcoma is an uncommon malignancy, with only a few reported cases worldwide. Although it exhibits multiple symptoms, facial paralysis has not been previously documented as a noticeable presentation.

Case Presentation
In this case, we report a 40-year-old male who presented with facial numbness and pain for one month, weakness of his facial muscles for 15 days, and recurrent right epistaxis for 1 year. He had a history of nasal inflammatory polyps with chronic sinusitis. Computed tomography and magnetic resonance imaging showed space-occupying lesions in the right nasal cavity and maxillary sinus, with bone destruction occurring in the sinus wall and turbinate. This patient then underwent endoscopic surgery. According to the histopathological and immunohistochemical results, he was eventually diagnosed with paranasal sinus angiosarcoma in April 2021. To date, this patient has not initiated any radiotherapy or chemotherapy and has survived with lymphatic metastasis for at least 3 years.

Conclusions
This manuscript suggests that paranasal sinus angiosarcoma can present with facial paralysis. Moreover, pathological and immunohistochemical tests are still vital for diagnosing paranasal sinus angiosarcoma and differential diagnosis. Additionally, regular follow-up is crucial for patients with paranasal sinus angiosarcoma, enabling monitoring of recurrence, metastasis, and recovery while contributing valuable clinical data to understanding this rare disease and associated research endeavours.
The global prevalence of low back pain in pregnancy: a comprehensive systematic review and meta-analysis
Authors: Salari Nader , Mohammadi Aida , Hemmati Mahvan , Hasheminezhad Razie , Kani Salim , Shohaimi Shamarina , Mohammadi Masoud 
Published: December 2023

Abstract
Background
Back pain during pregnancy is often considered as an unavoidable problem and can reduce the quality of life or disability of pregnant women. The aim of this study is to determine the global prevalence of back pain in pregnancy based on a systematic review and meta-analysis.

Methods
In this study, Researchers systematically searched electronic databases PubMed, Scopus, Web of Science, Embase, ScienceDirect, and Google Scholar search engines for studies until September 2023. To analyze data, the random effects model was used, and the heterogeneity of the studies was checked with the I2 index. Data analysis was performed by software (Version 2 Comprehensive Meta-Analysis).

Results
In the review of 28 studies with a sample size of 12,908 people, the I2 heterogeneity test showed high heterogeneity (I2: 98.4). Based on this, the random effects method was used to analyze the results. Therefore, the meta-analysis reported the global prevalence of back pain at 40.5 (95% CI: 33–48.4) during pregnancy. Also, according to the meta-analysis, the global prevalence of back pain in the first trimester of pregnancy is 28.3 (95%CI: 10.5–57.1), in the second trimester is 36.8 (95%CI: 30.4–43.7) and in the third trimester of pregnancy was reported as 47.8 (95% CI: 37.2–58.6).

Conclusion
In this meta-analysis, the overall prevalence of back pain in pregnant women was reported to be significant, so it is necessary for health policymakers to pay more attention to complications during pregnancy, in addition to increasing society's awareness of pregnant mothers, with timely diagnosis and treatment of such disorders, it can lead to improvement; and reduction in Complications caused by pregnancy and becoming more pleasant during pregnancy.
Determinants of mortality among pediatric patients admitted to Wolaita Sodo University Comprehensive Specialized Hospital with acute bacterial meningitis, Southern Ethiopia: an unmatched case–control study
Authors: Borko Ushula Deboch , Gelgelu Temesgen Bati , Zema Zewde , Alemu Afework , Dendir Getahun , Israel Eskinder , Abiso Temesgen Lera , Woldegeorgis Beshada Zerfu 
Published: December 2023

Abstract
Background
People of all ages suffer from acute bacterial meningitis, but children are the most vulnerable, accounting for over 50% of all cases and deaths in children under the age of five. It is the leading cause of morbidity, mortality, and long-term suffering worldwide. Children are at great risk of disease and mortality due to a lack of specific immunity associated with their young age. As a result, determinants of death were found among pediatric patients treated with acute bacterial meningitis at Wolaita Sodo University Comprehensive Specialized Hospital in Southern Ethiopia.

Methods
A facility-based unmatched case–control study was conducted on pediatric patients admitted with acute bacterial meningitis at Wolaita Sodo University Comprehensive Specialized Hospital from July 1, 2019, to June 30, 2022. A total of 355 (71 cases and 284 controls) pediatric medical charts were used for data extraction using a preestablished checklist. Data were checked for completeness and consistency, entered into Epi-Data version 4.6 software, and transported to SPSS version 25 for analysis. Multivariable logistic regression analysis was performed to identify the independent determinants of acute bacterial meningitis mortality at a P value of < 0.05 along with a 95% confidence interval (CI).

Results
Age between 2 months and 5 years (adjusted odds ratio (AOR) = 3.19, 95% CI = 1.15–8.88), admission in the summer season (AOR = 0.27, 95% CI = 0.15–0.49), and family size greater than or equal to six (AOR = 3.13, 95% CI = 1.76–5.56), initial antibiotic change (AOR = 10.81, 95% CI = 2.10–55.7), clinical features at presentation such as loss of consciousness (AOR = 16.90, 95% CI = 4.70–60.4), abnormal body movements (seizures) (AOR = 6.51, 95% CI = 1.82–23.4), increased intracranial pressure (AOR = 3.63, 95% CI = 1.78–7.4), malnutrition (AOR = 2.98, 95% CI = 1.34–6.59) and presence of more than one comorbidity (AOR = 3.03, 95% CI = 1.03–9.03) were found to be determinants of acute bacterial meningitis mortality.

Conclusions
In summary, children aged 2 months to 5 years from large families ( > = 6) with a history of initial antibiotic change, malnutrition, more than one comorbidity, and worse clinical characteristics were related to greater death due to acute bacterial mortality in this study.
Protocol for a randomised controlled trial of a healthy relationship tool for men who use intimate partner violence (BETTER MAN)
Authors: Hegarty Kelsey , Tarzia Laura , Navarro Medel Carolina , Hameed Mohajer , Chondros Patty , Gold Lisa , Tassone Simone , Feder Gene , Humphreys Cathy 
Published: December 2023

AbstractBackgroundIntimate partner violence (IPV) is common globally, but there is a lack of research on how to intervene early with men who might be using IPV. Building on evidence supporting the benefits of online interventions for women victim/survivors, this study aims to test whether a healthy relationship website (BETTER MAN) is effective at improving men’s help seeking, their recognition of behaviours as IPV and their readiness to change their behaviours.Methods/designIn this two-group, pragmatic randomised controlled trial, men aged 18–50 years residing in Australia who have been in an adult intimate relationship (female, male or non-binary partner) in the past 12 months are eligible. Men who report being worried about their behaviour or have had others express concerns about their behaviour towards a partner in the past 12 months will be randomised with a 1:1 allocation ratio to receive the BETTER MAN website or a comparator website (basic healthy relationships information). The BETTER MAN intervention includes self-directed, interactive reflection activities spread across three modules: Better Relationships, Better Values and Better Communication, with a final “action plan” of strategies and resources. Using an intention to treat approach, the primary analysis will estimate between-group difference in the proportion of men who report undertaking help-seeking behaviours for relationship issues in the last 6 months, at 6 months post-baseline. Analysis of secondary outcomes will estimate between-group differences in: (i) mean score of awareness of behaviours in relationships as abusive immediately post-use of website; (ii) mean score on readiness to change immediately post-use of website and 3 months after baseline; and (iii) cost-effectiveness.DiscussionThis trial will evaluate the effectiveness of an online healthy relationship tool for men who may use IPV. BETTER MAN could be incorporated into practice in community and health settings, providing an evidence-informed website to assist men to seek help to promote healthy relationships and reduce use of IPV.Trial registrationACTRN12622000786796 with the Australian New Zealand Clinical Trials Registry: 2 June 2022.Version: 1 (28 September 2023).
Motives for leisure-time physical activity participation: an analysis of their prevalence, consistency and associations with activity type and social background
Authors: Elmose-Østerlund Karsten , Dalgas Birgitte Westerskov , Bredahl Thomas Viskum Gjelstrup , Lenze Lars , Høyer-Kruse Jens , Ibsen Bjarne 
Published: December 2023

Abstract
Background
Studies argue that knowledge about motives for physical activity participation can inform activities, initiatives and interventions to promote physical activity. However, most of these studies are based on small sample sizes and only include participants within a few selected types of PA. Further, they have not examined the consistency of individuals’ motives across different activity types. As a result, this article examines RQ1: the most prevalent motives, RQ2: the association of motives with activity type and social background characteristics, and RQ3: the consistency of motives across different activity types.

Methods
We utilised data from a survey of physical activity participation among 163,000 adult Danes (aged 15 + years). In the survey, the participants were asked about their participation in thirteen activity types and about their motives for practising the activity types they reported to do at least weekly. The motive items were operationalised based on the eight dimensions in the Physical Activity and Leisure Motivation Scale (PALMS). We conducted analyses of mean values and standard deviations as well as multilevel regression analyses.

Results
We identified large differences in the importance of different motives for physical activity participation. The three most important motives were psychological condition (M = 4.54), physical condition (M = 4.48) and enjoyment (M = 4.36). We also found significant associations between motives and activity types in particular, but also between motives and social background characteristics (gender, age and educational level). For instance, we found that compared to running, physical condition was a much less important motive in outdoor activities (b = -3.01), activities on water (b = -2.44) and street sports (b = -2.38). Finally, our analysis showed how individuals’ motives are not consistent across different activity types.

Conclusions
Our study contributes to the literature on motives for physical activity participation by using a large sample of individuals and by differentiating motives according to a wide range of activity types. The results underline the need to study motives in relation to activity types, as there are large differences in the prevalence of different motives. Our findings suggest that motives are not consistent across activity types, but rather they develop in an interplay between the individual and the activity type practised.
Environmental quality and its impact on total fertility rate: an econometric analysis from a new perspective
Authors: Haq Shah Md Atiqul , Chowdhury Mohammad Ashraful Ferdous , Ahmed Khandaker Jafor , Chowdhury Mohammed Thanvir Ahmed 
Published: December 2023

Abstract
Background
Environmental quality significantly affects various aspects of human existence. This study employs ecological footprint as a proxy to assess the impact of environmental quality on the TFR, measured as births per woman. This study investigates the extent to which ecological footprint indicators impact on the TFR in across 31 countries between from 1990 to 2017.

Methods
We gathered data on ecological footprints, specifically carbon, agricultural land, grazing land, forest products, and fisheries, from the Global Footprint Network. Information on the TFR, Human Development Index (HDI), and per capita Gross National Income (GNI) were sourced from the World Bank and the United Nations. We applied static panel and quantile regression models to scrutinize the connection between the ecological footprint and TFR, showing how the former influences the latter.

Results
The outcomes reveal that, in both fixed and random effects models, factors including HDI, carbon, and fishing grounds exert a negative influence on TFR, all at a significance level of p < 0.01. Conversely, cropland and forest product footprints exhibited a favorable impact on the TFR (p < 0.01). Furthermore, GNI per capita positively affected the TFR in both models, with a p-value of 0.01. Quantiles regression analysis demonstrated that HDI and carbon footprint had a negative impact on TFR across all quantiles. This statistical significance is maintained for all quantiles, although it is only significant for the carbon footprint up to the 60th quantile, at p < 0.01.

Conclusions
This study establishes a negative correlation between specific ecological footprint indicators, such as carbon and fishing grounds, and TFR. Conversely, there was a positive correlation between the footprint of forest products and the TFR. The primary conclusion drawn is that there is heterogeneity in the results regarding the relationship between ecological footprint and TFR. Moreover, the ecological footprint indicators considered in this study did not uniformly influence TFR. Each ecological footprint indicator exhibited distinct effects on the TFR, displaying either positive or negative correlation coefficients. Future research endeavors may delve into how ecological footprints impact other population dynamics, such as mortality and migration.
Structural transition of parenthood among Chinese nulliparous couples with planned pregnancies, 2013–2019
Authors: Wang Long , Han Chunying , Lv Xinyi , Zeng Shuai , Mu Rongwei , Deng Yuzhi , Xie Wenlu , Huang Jiaxin , Wu Siyu , Zhang Ya , Zhang Hongguang , He Yuan , Peng Zuoqi , Wang Yuanyuan , Shen Haiping , Wang Qiaomei , Zhang Yiping , Yan Donghai , Yang Ying , Ma Xu 
Published: December 2023

Abstract
Background
The postponement of parenthood is a global public health issue that has received attention of many public health experts. However, few studies have investigated the postponement in marriage age, marriage and conception interval, and pregnancy age in terms of demographic and regional heterogenicities.

Methods
This is a cross-sectional, registry-based study, and a total of 13 894 601 nulliparous couples who participated in the National Free Pre-Pregnancy Check-ups Project and became pregnant during 2013–2019 were included. We calculated annual percentage change and forest plots for marriage age, marriage and conception interval, and pregnancy age.

Results
Late marriage (marriage age ≥ 35 years), long marriage and conception interval (marriage and conception interval ≥ 2 years), and advanced pregnancy (pregnancy age ≥ 35 years) increased from 1.20%, 22.01%, and 1.88% in 2013 to 1.69%, 32.75%, and 2.79% in 2019, respectively. The corresponding annual percentage changes were 6.55%, 8.44%, and 8.17%. Participants without higher education had a higher annual percentage change, but comparable prevalence for long marriage and conception interval with participants with higher education. Participants residing in second- or new first-tier cities, and the northeast of China who had a higher prevalence of parenthood postponement also had higher corresponding annual percentage changes.

Conclusions
Structural postponement of parenthood with demographic and regional heterogenicities was observed among Chinese nulliparous couples with planned pregnancies during 2013–2019. Inclusive and comprehensive parenting support should be developed and implemented in mainland China to minimize the negative health effects arising from the postponement, especially for couples without higher education and living in new first/second-tier cities or the northeast China.