bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating alternative pathway complement cleavage factor Bb is associated with vascular lesions and outcomes in IgA nephropathy
Authors: Ștefan Gabriel , Jullien Perrine , Masson Ingrid , Alamartine Eric , Mariat Christophe , Maillard Nicolas 
Published: October 2023

ABSTRACT

Background
Complement alternative pathway (AP) activation is linked to immunoglobulin A nephropathy (IgAN) prognosis severity, but Bb fragment's role is unclear. We examined the relationship between serum Bb fragment concentration at IgAN diagnosis and disease activity and outcomes.

Methods
This retrospective study included 125 biopsy-proven IgAN patients [age 39.9 years, 75% male, estimated glomerular filtration rate (eGFR) 82 ml/min, proteinuria 0.5 g/day] enrolled from 1984 to 2010 and followed for a minimum of 18 months. Monitoring continued until the last follow-up, end-stage kidney disease (ESKD) or death. Serum Bb fragment was measured using an enzyme-linked immunosorbent assay at diagnosis. Oxford classification and global optical score (GOS) were utilized for pathology assessment.

Results
Patients were followed for a median of 16 years; 42% developed chronic kidney disease stage ≥3, 19% reached ESKD and 9% died. Serum Bb fragment concentration negatively correlated with eGFR values at the last follow-up and positively with vascular and tubular histopathological indices. In univariate Cox regression analyses, higher Bb fragment concentration was associated with ESKD alongside older age, increased body mass index, arterial hypertension, lower eGFR, higher proteinuria, E1, S1, T1–2, GOS and corticotherapy. Patients with Bb levels ≥14.3 μg/ml had shorter mean kidney survival time (19.5 versus 22.7 years, P = .07); after adjusting for progression risk factors, the association persisted [hazard ratio 4.76 (95% confidence interval 1.56–14.43)].

Conclusions
Serum Bb fragment concentration at diagnosis may predict long-term IgAN outcomes, potentially due to AP activation at the endothelial surface. Further research is needed to confirm these results and evaluate Bb fragment's role in IgAN management.
The plethora of immunomodulatory drugs: opportunities for immune-mediated kidney diseases
Authors: Odler Balazs , Tieu Johanna , Artinger Katharina , Chen-Xu Michael , Arnaud Laurent , Kitching Richard A , Terrier Benjamin , Thiel Jens , Cid Maria C , Rosenkranz Alexander R , Kronbichler Andreas , Jayne David R W 
Published: October 2023

ABSTRACT
In recent decades, insights into the molecular pathways involved in disease have revolutionized the treatment of autoimmune diseases. A plethora of targeted therapies have been identified and are at varying stages of clinical development in renal autoimmunity. Some of these agents, such as rituximab or avacopan, have been approved for the treatment of immune-mediated kidney disease, but kidney disease lags behind more common autoimmune disorders in new drug development. Evidence is accumulating as to the importance of adaptive immunity, including abnormalities in T-cell activation and signaling, and aberrant B-cell function. Furthermore, innate immunity, particularly the complement and myeloid systems, as well as pathologic responses in tissue repair and fibrosis, play a key role in disease. Collectively, these mechanistic studies in innate and adaptive immunity have provided new insights into mechanisms of glomerular injury in immune-mediated kidney diseases. In addition, inflammatory pathways common to several autoimmune conditions exist, suggesting that the repurposing of some existing drugs for the treatment of immune-mediated kidney diseases is a logical strategy. This new understanding challenges the clinical investigator to translate new knowledge into novel therapies leading to better disease outcomes. This review highlights promising immunomodulatory therapies tested for immune-mediated kidney diseases as a primary indication, details current clinical trials and discusses pathways that could be targeted in the future.
Dissipationless layertronics in axion insulator MnBi2Te4
Authors: Li Shuai , Gong Ming , Cheng Shuguang , Jiang Hua , Xie X C 
Published: October 2023

ABSTRACT
Surface electrons in axion insulators are endowed with a topological layer degree of freedom followed by exotic transport phenomena, e.g., the layer Hall effect. Here, we propose that such a layer degree of freedom can be manipulated in a dissipationless way based on the antiferromagnetic $\rm {MnBi_2Te_4}$ with tailored domain structure. This makes $\rm {MnBi_2Te_4}$ a versatile platform to exploit the ‘layertronics’ to encode, process and store information. Importantly, the layer filter, layer valve and layer reverser devices can be achieved using the layer-locked chiral domain wall modes. The dissipationless nature of the domain wall modes makes the performance of the layertronic devices superior to those in spintronics and valleytronics. Specifically, the layer reverser, a layer version of the Datta–Das transistor, also fills up the blank in designing the valley reverser in valleytronics. Our work sheds light on constructing new generation electronic devices with high performance and low-energy consumption in the framework of layertronics.
Randomized Controlled Trial of Aerobic Exercise for Smoking Cessation Among Individuals With Elevated Depressive Symptoms
Authors: Abrantes Ana M , Browne Julia , Uebelacker Lisa A , Anderson Bradley J , Barter Sarah , Shah Zainab , Kunicki Zachary J , Caviness Celeste , Price Lawrence H , Desaulniers Julie , Brown Richard A 
Published: October 2023

Abstract

Introduction
Adults with depression have higher rates of cigarette smoking and are more likely to relapse than those without depression. Pharmacological, psychological, and combined interventions have largely yielded small improvements in smoking outcomes for adults with depression. Aerobic exercise (AE) may facilitate smoking cessation in this subpopulation.

Methods
This study was a 12-week two-arm randomized controlled trial that evaluated the effect of a moderate-intensity AE program compared to a health education contact (HEC) control on smoking cessation in adults with elevated depressive symptoms (mild to severe). Participants (n = 231) were randomized to AE or HEC and received smoking cessation treatment (telephone counseling and nicotine replacement therapy). Primary (biologically confirmed 7-day point prevalence abstinence) and secondary (depressive symptoms, objective and self-reported physical activity, and cardiorespiratory fitness) outcomes were assessed at baseline, 3, 6, and 12 months. Data were analyzed with mixed-effects generalized linear models controlling for age, gender, nicotine dependence, history of major depression disorder, and month of follow-up assessment.

Results
There were no significant differences in primary or secondary outcomes between the AE and HEC groups.

Conclusions
The AE program was not superior to HEC in facilitating smoking cessation, increases in physical activity, or improved depressive symptoms. Given evidence for the positive acute effects of exercise on mood and smoking urges, future research should consider testing alternative exercise approaches for aiding smoking cessation beyond structured, AE programs.

Implications
This study found that an adjunctive aerobic exercise (AE) program was not superior to a health education contact control for adults with elevated depressive symptoms, all of whom also received standard smoking cessation treatment. This finding adds to the growing body of literature that structured AE programs for smoking cessation may have limited efficacy for cessation outcomes. Future research is needed to test alternative methods of integrating AE into smoking cessation treatment, such as strategically using exercise to manage cravings and low mood in the moment.
An Extended Calibration of the Olivine–Spinel Aluminum Exchange Thermometer: Application to the Melting Conditions and Mantle Lithologies of Large Igneous Provinces
Authors: Zhang Yishen , Namur Olivier , Li Weiran , Shorttle Oliver , Gazel Esteban , Jennings Eleanor , Thy Peter , Grove Timothy L , Charlier Bernard 
Published: October 2023

Abstract
The application of the olivine–spinel aluminum exchange thermometer to natural samples is limited by the restricted experimental data set on which it was calibrated. Here, we present a new data set of 46 high-temperature crystallization experiments and 21 reanalyzed published experiments, which we used to extend the calibration to higher and lower temperatures. The final calibration data set spans a range of conditions relevant to crustal and upper mantle processes: 1174–1606°C, 0.1–1350 MPa, QFM − 2.5 to QFM + 7.2 (oxygen fugacity, fO2, reported in log units relative to the quartz–fayalite–magnetite buffer, QFM), and 0–7.4 wt % H2Omelt. We propose three new models. The first is thermodynamically self-consistent, based on spinel Fe, Mg, Al, and Cr compositions and Al exchange between olivine and spinel. The second and third are empirical models that consider fewer elemental exchanges: the second uses only Al exchange and spinel compositions, whereas the third considers olivine–spinel Al and Cr exchange. All models include the modest effect of pressure on olivine-spinel equilibrium chemistry, whereas fO2 and water content have negligible effects. In general, as fewer elements are considered in the olivine–spinel exchange, the fit to experimental data worsens. Conversely, the associated decrease in model complexity improves their robustness against systematic errors when applied to natural crystal pairs: the thermodynamic model may underestimate crystallization temperatures in natural samples due to spinel subsolidus re-equilibration, whereas the empirical models (independent of Fe and Mg in spinel) are less sensitive to re-equilibration but yield temperatures with larger uncertainties. We applied a statistical test to select the most appropriate model for application to natural samples. When applied to lavas from mid-ocean ridges, Iceland, Skye, Emeishan, Etendeka, and Tortugal, our new temperature estimates are 30–100°C lower than previously proposed. The lower temperature estimates cause a lower mantle melting temperature and significant impacts on the mantle lithology constraints.
Strength in numbers: An isoform variety of homogalacturonan modifying enzymes may contribute to pollen tube fitness
Authors: Kamel Hiba , Geitmann Anja 
Published: October 2023

Abstract
Pectin is a major component of the cell wall in land plants. It plays crucial roles in cell wall assembly, cell growth, shaping, and signaling. The relative abundance of pectin in the cell wall is particularly high in rapidly growing organ regions and cell types. Homogalacturonan (HG), a polymer of 1,4-linked α-D-galacturonic acid, is a major pectin constituent in growing and dividing plant cells. In pollen tubes, an extremely rapidly growing cell type, HG is secreted at and inserted into the apical cell wall and is subject to further modification in muro by HG modifying enzymes (HGMEs). These enzymes, including pectin esterases and depolymerases, have multiple isoforms, some of which are specifically expressed in pollen. Given the importance of pectin chemistry for the fitness of pollen tubes, it is of interest to interrogate the potentially crucial roles these isoforms play in pollen germination and elongation. It is hypothesized that different HGME isoforms, through their action on apoplastic HG, may generate differential methylation and acetylation patterns endowing HG polysaccharides with specific, spatially and temporally varying properties that lead to a fine-tuned pattern of cell wall modification. In addition, these isoforms may be differentially activated and/or inhibited depending on the local conditions that may vary at subcellular resolution. In this Update we review the different HGME isoforms identified in recent years in Arabidopsis thaliana and postulate that the multiplicity of these isoforms may allow for specialized substrate recognition and conditional activation, leading to a sophisticated regulation scheme exemplified in the process that governs the dynamic properties of the cell wall in pollen tube growth.
Elevated risk of multimorbidity post-COVID-19 infection: protective effect of vaccination
Authors: Lai F T T , Liu W , Hu Y , Wei C , Chu R Y K , Lum D H , Leung J C N , Cheng F W T , Chui C S L , Li X , Wan E Y F , Wong C K H , Cheung C L , Chan E W Y , Hung I F N , Wong I C K 
Published: October 2023

SummaryBackgroundIt is unclear how the coronavirus disease 2019 (Covid-19) pandemic has affected multimorbidity incidence among those with one pre-existing chronic condition, as well as how vaccination could modify this association.AimTo examine the association of Covid-19 infection with multimorbidity incidence among people with one pre-existing chronic condition, including those with prior vaccination.DesignNested case–control study.MethodsWe conducted a territory-wide nested case–control study with incidence density sampling using Hong Kong electronic health records from public healthcare facilities and mandatory Covid-19 reports. People with one listed chronic condition (based on a list of 30) who developed multimorbidity during 1 January 2020–15 November 2022 were selected as case participants and randomly matched with up to 10 people of the same age, sex and with the same first chronic condition without having developed multimorbidity at that point. Conditional logistic regression was used to estimate adjusted odds ratios (aORs) of multimorbidity.ResultsIn total, 127 744 case participants were matched with 1 230 636 control participants. Adjusted analysis showed that there were 28%-increased odds of multimorbidity following Covid-19 [confidence interval (CI) 22% to 36%] but only 3% (non-significant) with prior full vaccination with BNT162b2 or CoronaVac (95% CI −2% to 7%). Similar associations were observed in men, women, older people aged 65 or more, and people aged 64 or younger.ConclusionsWe found a significantly elevated risk of multimorbidity following a Covid-19 episode among people with one pre-existing chronic condition. Full vaccination significantly reduced this risk increase.
Endorsing a Biopsychosocial Perspective of Pain in Individuals With Chronic Pain
Authors: Kleinstäuber Maria , Garland Eric L. , Sisco-Taylor Brittany L. , Sanyer Mathias , Corfe-Tan Julia , Barke Antonia 
Published: October 2023

Objectives:
Patients’ beliefs about pain play an important role in their readiness to engage with chronic pain self-management. The central aim of this study was to validate a self-report instrument to assess a specific set of pain beliefs, patients’ endorsement of a biopsychosocial model of chronic pain (PEB).

Methods:
Interdisciplinary experts in the field of pain were involved in creating an instrument, the PEB Scale, to operationalize patients’ endorsement of a biopsychosocial model. A sample of 199 patients with chronic pain was recruited to evaluate the factorial structure (principal axis factoring), the internal consistency (Cronbach’s alpha), the convergent and discriminant validity (correlational analyses), incremental validity (multiple, hierarchical regression analyses), and construct validity (differential population analysis) of the instrument.

Results:
The factor analysis resulted in a unidimensional, 11-item instrument that explained 51.2% of the total variance. Cronbach’s alpha (= 0.92) indicated high internal consistency of the created set of pain-related beliefs. Regression analyses demonstrated that PEB is a strong predictor of patients’ engagement with pain self-management (P < 0.001), after controlling for demographic variables, anxiety, depression, and other pain-related beliefs.

Discussion:
Our results show that the PEB Scale is a highly reliable self-report instrument, which has the potential to predict patients’ readiness to adopt pain self-management. Future research should focus on re-validating the scale we developed to operationalize PEB. Moreover, the PEB Scale should be implemented in longitudinal study designs to investigate its ability to predict the transition from acute to chronic pain and patients’ long-term pain management.
Medications for Opioid Use Disorder and Mortality and Hospitalization Among People With Opioid Use-related Infections
Authors: Figgatt Mary C. , Hincapie-Castillo Juan M. , Schranz Asher J. , Dasgupta Nabarun , Edwards Jessie K. , Jackson Bradford E. , Marshall Stephen W. , Golightly Yvonne M. 
Published: October 2023

Background:Severe skin and soft tissue infections related to injection drug use have increased in concordance with a shift to heroin and illicitly manufactured fentanyl. Opioid agonist therapy medications (methadone and buprenorphine) may improve long-term outcomes by reducing injection drug use. We aimed to examine the association of medication use with mortality among people with opioid use-related skin or soft tissue infections.Methods:An observational cohort study of Medicaid enrollees aged 18 years or older following their first documented medical encounters for opioid use-related skin or soft tissue infections during 2007–2018 in North Carolina. The exposure was documented medication use (methadone or buprenorphine claim) in the first 30 days following initial infection compared with no medication claim. Using Kaplan–Meier estimators, we examined the difference in 3-year incidence of mortality by medication use, weighted for year, age, comorbidities, and length of hospital stay.Results:In this sample, there were 13,286 people with opioid use-related skin or soft tissue infections. The median age was 37 years, 68% were women, and 78% were white. In Kaplan–Meier curves for the total study population, 12 of every 100 patients died during the first 3 years. In weighted models, for every 100 people who used medications, there were four fewer deaths over 3 years (95% confidence interval = 2, 6).Conclusion:In this study, people with opioid use-related skin and soft tissue infections had a high risk of mortality following their initial healthcare visit for infections. Methadone or buprenorphine use was associated with reductions in mortality.
Eyebrow Restoration in Deep Facial Burn: Follicular Unit Extraction Hair Transplantation after Nanofat Graft
Authors: Ali Rama A. , Fayek Mina , Noureldin Marwan , El-Essawy Nadeen M. 
Published: October 2023

Background:
Eyebrows play an important role in protecting the eyes, and also transmit facial expression. Restoration of eyebrow loss after deep thermal burns is a challenging task because a scarred recipient area may affect the success rate of the hair transplantation outcome. Trials to improve this outcome via preparation of pretransplantation recipient area are mandatory.

Methodology:
Seventeen patients (20 eyebrows) with partial or total postburn eyebrow loss were recruited. Nanofat injection was done as a preparatory step before hair transplantation. Patients were followed up monthly for 6 months after follicular unit extraction. The outcome was assessed both objectively by phototrichoscopy and patient satisfaction, and by incidence of complications.

Results:
The mean eyebrow density of the recipient side was found to be 88.60 ± 29.96 hair follicle per cm2, compared with 133.95 ± 38.38 on the control side. The mean eyebrow thickness of the recipient side was found to be 0.07 ± 0.01 mm, compared with 0.06 ± 0.01 on the control side, The overall satisfaction was 60% regarding the density, 80% regarding direction, and 65% regarding symmetry. However, when it comes to texture, 45% were satisfied.

Conclusions:
Restoration of eyebrow loss after deep facial burn is a challenging procedure. Improving the recipient area before hair transplantation is recommended to achieve a satisfactory outcome. Waiting until maturation of the scarred tissue of the recipient area and preparation of it with nanofat can achieve a satisfactory outcome.
A Retrospective Review of Arthroscopic Shaver Utilization in Adolescent Gynecomastia
Authors: Belza Caitlyn C. , Blum Jessica D. , Neubauer Daniel , Reid Christopher M. , Ortiz-Pomales Yan T. , Lance Samuel H. 
Published: October 2023

Background:
This study compares the arthroscopic shaver and liposuction with other established methods for treatment of adolescent gynecomastia.

Methods:
Surgical management was via four operative techniques: open excision, open excision/liposuction, arthroscopic shaver/liposuction, or open excision and free nipple graft. Data were collected and compared using independent t tests, linear regression models, and one-way analysis of variance.

Results:
Patients were stratified by Rohrich grades I -II (low) (N = 47) or III -IV (high) (N = 13). The groups were similar in age (P = 0.662) with lower BMI in the low-grade group (x̄ = 25.36 ± 2.1) vs. high-grade group (x̄ = 27.62 ± 4.0; P < 0.001). The low-grade group showed no significant difference in operative time across surgical techniques with decreased mean operative time in the high-grade group using the arthroscopic shaver technique (x̄ = 55.8 ± 7.56) compared with open excision (x̄ = 70.83 ± 11.02, P = 0.04), open excision plus liposuction (x̄ = 89.5 ± 24.93, P = 24.93), and open excision plus free nipple graft (x̄ = 81.67 ± 19.11, P = 0.05). There was no significant difference in complication (P = 0.84) or reoperation (P = 0.68) rates across surgical techniques regardless of grade.

Conclusions:
These findings suggest that the arthroscopic shaver is safe and effective for treatment of both low- and high-grade gynecomastia in adolescents. The results yielded a similar incidence of complications and reoperation across surgical techniques, and the arthroscopic shaver approach demonstrated a shorter operative time compared with other techniques for high-grade gynecomastia.
Risk of injuries before and after a diagnosis of cirrhosis: A population-based cohort study
Authors: Shang Ying , Shen Qing , Tapper Elliot B. , Wester Axel , Hagström Hannes 
Published: October 2023

Background:
Cirrhosis is often asymptomatic prior to decompensation. Still, cognitive impairment and sarcopenia may be present before decompensation, possibly increasing the risk of injuries. We estimated the risk of injuries during the period shortly before and after cirrhosis diagnosis.

Methods:
All patients (N=59,329) with a diagnosis of cirrhosis from 1997 to 2019 were identified from the Swedish National Patient Register. We used a self-controlled case series design to compare the incidence rates (IR) of injuries during a “diagnostic period” (within 3 months before or after the cirrhosis diagnosis date) to a self-controlled “prediagnostic period” (the same 6 calendar months 3 years before diagnosis), using conditional Poisson regression. Injuries were ascertained from the National Patient Register.

Results:
We identified 23,733 (40.0%) patients with compensated and 35,595 (60.0%) with decompensated cirrhosis. There were 975 injuries (IR 2.8/1000 person-months) during the prediagnostic period, and 3610 injuries (IR 11.6/1000 person-months) identified during the diagnostic period. The IR ratio was 8.1 (95% CI 7.5–8.7) comparing the diagnostic period with the prediagnostic period. For patients with compensated cirrhosis, the risk increment of injuries was highest just before the diagnosis of cirrhosis, whereas the risk increase was highest shortly after the diagnosis for those with decompensation.

Conclusions:
The incidence of injuries increases shortly before and after the diagnosis of cirrhosis. These findings indicate that cirrhosis is frequently diagnosed in conjunction with an injury, and highlight the need for injury prevention after cirrhosis diagnosis, especially in patients with decompensation.