bluuebunny/crossref_metadata_2025_split huggingface dataset:
JERUSALEM, A HOLY AND CREATIVE CITY: Advisory Practices and the Grounding of Urban Mobilities within the Context of Ethnic Conflict
Authors: Rullansky Ignacio 
Published: December 2023

AbstractThis article assesses how the agency of international advisors can provide policy recommendations that, instead of introducing urban policy initiatives for multicultural encounters, sharpen political and spatial segregation within the context of ethnic conflict. The article explores the variegated nature of neoliberalization and argues that the adoption of strategic planning and creativity discourses enables the development of a sophisticated political rationale for governing ethnic diversity. The analysis focuses on a range of advisory practices—including the role played by Michael Porter at the Harvard Business School and Richard Florida at the Creative Class Group in advising former Jerusalem mayor Nir Barkat—in order to understand the dynamics of grounding imaginaries concerning a neoliberal role for the state and the depoliticization of the public sphere in a disputed city. By surveying official policy documents, journalistic interviews and two reports submitted by Porter and Florida to Barkat, the author examines how the branding of Jerusalem as a creative city involved managerial practices that classified the city's diverse population according to categories of creative and non‐creative labor rather than political subjects. The adoption of such discourses facilitated a novel approach for enhancing the state‐building ethno‐nationalistic project while at the same time reproducing the dynamics of occupation and annexation.
Blood pressure measurement and adverse pregnancy outcomes: A cohort study testing blood pressure variability and alternatives to 140/90 mmHg
Authors: Wilson Milly G. , Bone Jeffrey N. , Slade Laura J. , Mistry Hiten D. , Singer Joel , Crozier Sarah R. , Godfrey Keith M. , Baird Janis , von Dadelszen Peter , Magee Laura A. 
Published: December 2023

AbstractObjectiveTo examine the association with adverse pregnancy outcomes of: (1) American College of Cardiology/American Heart Association blood pressure (BP) thresholds, and (2) visit‐to‐visit BP variability (BPV), adjusted for BP level.DesignAn observational study.SettingAnalysis of data from the population‐based UK Southampton Women's Survey (SWS).Population or sample3003 SWS participants.MethodsGeneralised estimating equations were used to estimate crude and adjusted relative risks (RRs) of adverse pregnancy outcomes by BP thresholds, and by BPV (as standard deviation [SD], average real variability [ARV] and variability independent of the mean [VIM]). Likelihood ratios (LRs) were calculated to evaluate diagnostic test properties, for BP at or above a threshold, compared with those below.Main outcome measuresGestational hypertension, severe hypertension, pre‐eclampsia, preterm birth (PTB), small‐for‐gestational‐age (SGA) infants, neonatal intensive care unit (NICU) admission.ResultsA median of 11 BP measurements were included per participant. For BP at ≥20 weeks’ gestation, higher BP was associated with more adverse pregnancy outcomes; however, only BP <140/90 mmHg was a good rule‐out test (negative LR <0.20) for pre‐eclampsia and BP ≥140/90 mmHg a good rule‐in test (positive LR >8.00) for the condition. BP ≥160/110 mmHg could rule‐in PTB, SGA infants and NICU admission (positive LR >5.0). Higher BPV (by SD, ARV, or VIM) was associated with gestational hypertension, severe hypertension, pre‐eclampsia, PTB, SGA and NICU admission (adjusted RRs 1.05–1.39).ConclusionsWhile our findings do not support lowering the BP threshold for pregnancy hypertension, they suggest BPV could be useful to identify elevated risk of adverse outcomes.
Laparoscopic single anastomosis sleeve ileal bypass in the surgical management of morbid obesity: A single‐centre experience
Authors: Barakat Hosam , Hassan Alhassan , Elsheikh Mohamed , Abdelhamid Amir 
Published: December 2023

AbstractBackgroundSingle anastomosis sleeve ileal (SASI) bypass is a recently developed two‐step bariatric operation that involves a sleeve gastrectomy followed by a side‐to‐side sleeve‐ileal anastomosis. While the primary outcomes are promising, more evidence is required before SASI can be considered a standard bariatric procedure.ObjectiveThis study aims to evaluate short‐term outcomes of SASI bypass regarding safety, efficacy and complications.MethodsThis retrospective study involved the analysis of 75 patients who underwent SASI between January 2019 and January 2022. The study examined patients’ characteristics, comorbidities, surgical technique, operative details, post‐operative weight loss and complications.ResultsOf the 88 patients who underwent SASI, 13 were excluded, leaving 75 participants for analysis. The mean age was 36.9 ± 8.3 years, and the mean body mass index was 49.23 ± 5.5 kg/m2. Among the participants, 19 patients (25.3%) had diabetes and 8 patients (10.6%) had hypertension. The mean operative time was 78.42 ± 13.18 min. The mean excess weight loss percentage was 25.53 ± 3.63, 43.33 ± 8.78, 63.51 ± 10.85, 82.11 ± 11.42 and 88.95 ± 8.69 at 1, 3, 6, 12 and 24 months, respectively. The diabetic remission rate was 100%, and the hypertension remission rate was 75%. Post‐operative complications were observed in 12 patients (16%), with most being minor. Notably, two patients underwent SASI reversal to sleeve gastrectomy due to excessive weight loss, and one patient experienced weight regain in the second post‐operative year.ConclusionSASI bypass emerges as a straightforward and highly effective bariatric procedure, with an acceptable complication rate. It is easy to perform and revise, offering not only excellent and sustained weight loss outcomes during short‐term follow‐up but also the resolution or improvement of obesity‐associated comorbidities.
Composition of Roman period pottery from Jerusalem revisited
Authors: Yellin Joseph 
Published: December 2023

AbstractA study of the L'MLK jar handles based on neutron activation analysis reported an average chemical composition of Roman period pottery excavated in Jerusalem. Evidence was presented supporting the idea that the pottery, made of Motza clay, was made in Jerusalem or vicinity. Recently, the validity of the group composition as well as its assignment to Jerusalem as the origin of this composition was questioned. In this article, I present the unpublished data for individual pot shards comprising the chemical group and take a new look at the data on which the reported average composition was based. It is shown that the reported group composition is valid and that the suggestion that the group represents Hebron and not Jerusalem is not convincing but commends further exploration.
Qualitative and quantitative analyses in sulfated glycosaminoglycans, chondroitin sulfate/dermatan sulfate, during 3T3‐L1 adipocytes differentiation
Authors: Cahyadi Danang Dwi , Warita Katsuhiko , Takeda‐Okuda Naoko , Tamura Jun‐ichi , Hosaka Yoshinao Z. 
Published: December 2023

AbstractChondroitin sulfate/dermatan sulfate (CS/DS) is a member of glycosaminoglycans (GAGs) found in animal tissues. Major CS/DS subclasses, O, A, C, D, and E units, exist based on the sulfation pattern in d‐glucuronic acid (GlcA) and N‐acetyl‐d‐galactosamine repeating units. DS is formed when GlcA is epimerized into l‐iduronic acid. Our study aimed to analyze the CS/DS profile in 3T3‐L1 cells before and after adipogenic induction. CS/DS contents, molecular weight (Mw), and sulfation pattern were analyzed by using high‐performance liquid chromatography. CS/DS synthesis‐ and sulfotransferase‐related genes were analyzed by reverse transcription real‐time PCR. CS/DS amount was significantly decreased in the differentiated (DI) group compared to the non‐differentiated (ND) group, along with a lower expression of CS biosynthesis‐related genes, chondroitin sulfate N‐acetylgalactosaminyltransferase 1 and 2, as well as chondroitin polymerizing factor. GAGs in the DI group also showed lower Mw than those of ND. Furthermore, the A unit was the major CS/DS in both groups, with a proportionally higher CS‐A in the DI group. This was consistent with the expression of carbohydrate sulfotransferase 12 that encodes chondroitin 4‐O‐sulfotransferase, for CS‐A formation. These qualitative and quantitative changes in CS/DS and CS/DS‐synthases before and after adipocyte differentiation reveal valuable insights into adipocyte development.
Advanced systemic mastocytosis—Revised classification, new drugs and how we treat
Authors: Pardanani Animesh , Reichard Kaaren , Tefferi Ayalew 
Published: December 2023

SummaryMastocytosis constitutes the neoplastic proliferation of mast cells and is broadly classified into systemic mastocytosis (SM), cutaneous mastocytosis and mast cell sarcoma. SM is further partitioned into advanced (AdvSM) and non‐advanced (SM‐non‐Adv) subcategories. AdvSM includes aggressive SM (ASM), SM with an associated haematological neoplasm (SM‐AHN) and mast cell leukaemia (MCL). In 2022, two separate expert committees representing the 5th edition of the World Health Organization (WHO5) and the International Consensus (ICC) classification systems submitted revised classification criteria for SM, highlighted by the ICC‐proposed incorporation of mast cell cytomorphology in the diagnostic criteria for MCL and myeloid‐lineage restriction for the AHN component in SM‐AHN. Recent developments in SM also include the introduction of KIT‐targeting tyrosine kinase inhibitors (KITi), including midostaurin and avapritinib, both drugs have shown potent activity in reducing mast cell and mutant KIT burden and alleviating mast cell‐associated organopathy and mediator symptoms; however, their overall impact on survival or superiority over pre‐KITi era treatment options (e.g. cladribine) has not been studied in a controlled setting. In the current review, we provide a summary of recent changes in disease classification and an analysis of recent clinical trials and their impact on our current treatment approach in AdvSM.
“What a tale we have been in”: Emplotment and the Exemplar Characters in The Lord of the Rings and the Harry Potter Series
Authors: Milbank Alison 
Published: December 2023

AbstractLinda Zagzebski's theory of moral exemplarity emphasizes the importance of admiration in developing ethical behavior. This essay argues that admiration involves wonder and distance and is best evoked by mixed or flawed characters; it demonstrates this through discussion of the characters in J. R. R. Tolkien's The Lord of the Rings and J. K. Rowling's Harry Potter series. Using Paul Ricoeur's taxonomy of prefiguration, configuration, and refiguration in narrative work, it discerns a self‐reflexivity in the protagonists of these fantasy novels, which is echoed by that of the readers, who are brought to realize their own emplotment in larger narratives. Features in Tolkien and Rowling that aid this exploratory reading include the length and depth of the novels, the decentering of the reader's own reality, and their open endings, which offer an invitational role to further interpretation. Virtue is viewed more teleologically than in Zagzebski, for moral realism is woven into the metaphysics of these novels, which allows mimesis of flawed characters to be ethically productive.
Anoxia begets anoxia: A positive feedback to the deoxygenation of temperate lakes
Authors: Lewis Abigail S. L. , Lau Maximilian P. , Jane Stephen F. , Rose Kevin C. , Be'eri‐Shlevin Yaron , Burnet Sarah H. , Clayer François , Feuchtmayr Heidrun , Grossart Hans‐Peter , Howard Dexter W. , Mariash Heather , Delgado Martin Jordi , North Rebecca L. , Oleksy Isabella , Pilla Rachel M. , Smagula Amy P. , Sommaruga Ruben , Steiner Sara E. , Verburg Piet , Wain Danielle , Weyhenmeyer Gesa A. , Carey Cayelan C. 
Published: December 2023

AbstractDeclining oxygen concentrations in the deep waters of lakes worldwide pose a pressing environmental and societal challenge. Existing theory suggests that low deep‐water dissolved oxygen (DO) concentrations could trigger a positive feedback through which anoxia (i.e., very low DO) during a given summer begets increasingly severe occurrences of anoxia in following summers. Specifically, anoxic conditions can promote nutrient release from sediments, thereby stimulating phytoplankton growth, and subsequent phytoplankton decomposition can fuel heterotrophic respiration, resulting in increased spatial extent and duration of anoxia. However, while the individual relationships in this feedback are well established, to our knowledge, there has not been a systematic analysis within or across lakes that simultaneously demonstrates all of the mechanisms necessary to produce a positive feedback that reinforces anoxia. Here, we compiled data from 656 widespread temperate lakes and reservoirs to analyze the proposed anoxia begets anoxia feedback. Lakes in the dataset span a broad range of surface area (1–126,909 ha), maximum depth (6–370 m), and morphometry, with a median time‐series duration of 30 years at each lake. Using linear mixed models, we found support for each of the positive feedback relationships between anoxia, phosphorus concentrations, chlorophyll a concentrations, and oxygen demand across the 656‐lake dataset. Likewise, we found further support for these relationships by analyzing time‐series data from individual lakes. Our results indicate that the strength of these feedback relationships may vary with lake‐specific characteristics: For example, we found that surface phosphorus concentrations were more positively associated with chlorophyll a in high‐phosphorus lakes, and oxygen demand had a stronger influence on the extent of anoxia in deep lakes. Taken together, these results support the existence of a positive feedback that could magnify the effects of climate change and other anthropogenic pressures driving the development of anoxia in lakes around the world.
Relationship between a gum‐chewing routine and oral, physical, and cognitive functions of community‐dwelling older adults: A Kashiwa cohort study
Authors: Kawamura Jun , Tanaka Tomoki , Kanno Susumu , Osawa Kenji , Okabayashi Kazuto , Hirano Hirohiko , Shirobe Maki , Nagatani Miyuki , Son Bo‐Kyung , Lyu Weida , Iijima Katsuya 
Published: December 2023

AimAs associations between oral function and general health have been reported in community‐dwelling older adults, easily implementable preventive measures are urgently required. We focused on the health benefits of gum chewing, as no studies have been carried out on the impact of gum‐chewing routines on the health of older adults. This cross‐sectional study aimed to determine whether the gum‐chewing routine is associated with oral, physical and cognitive functions in community‐dwelling older adults.MethodsThis study included 1617 community‐dwelling older participants in a health survey carried out in 2021. The gum‐chewing routine and weekly chewing time were assessed using a self‐administered questionnaire. The outcome measures, including actual measurements of oral function, physical function, cognitive function, dietary intake and lifestyle, were evaluated using self‐administered questionnaires or health surveys.ResultsWe analyzed 1474 (mean age 76.1 ± 5.8 years, 45% women) participants for whom all data were not missing, and 14% of them had a gum‐chewing routine for more than 30 min weekly. Oral functions were significantly higher in older adults with a gum‐chewing routine, and there were substantially fewer participants with oral frailty (adjusted odds ratio 0.581, 95% confidence interval 0.340–0.993). Additionally, cognitive and physical functions, including grip strength, were significantly higher in the gum‐chewing routine group.ConclusionsCommunity‐dwelling older adults with a gum‐chewing routine have higher oral, physical and cognitive functions. These findings indicate that a gum‐chewing routine might contribute to maintaining oral function and preventing frailty. Geriatr Gerontol Int 2024; 24: 68–74.
Circular RNA circVAPA modulates macrophage pyroptosis in sepsis‐induced acute lung injury through targeting miR‐212‐3p/Sirt1/Nrf2/NLRP3 axis
Authors: Huang Yanjing , Lin Jinquan , Wu Zhiwei , Li Yiming 
Published: December 2023

AbstractSepsis‐induced acute lung injury (ALI) is an inflammatory condition involving the pyroptosis of macrophages. This study investigated the role of circular RNA hsa_circ_0006990 (circVAPA) in regulating macrophage pyroptosis in ALI and the underlying mechanisms. The expression pattern of circVAPA was examined in the mouse model of ALI and in the LPS‐treated RAW264.7 macrophage cell line. Lung tissue damage was evaluated by haematoxylin and eosin staining, immunohistochemistry and a myeloperoxidase activity assay. The molecular mechanisms were investigated by luciferase reporter assay, western blot, RT‐qPCR and ELISA. circVAPA was down‐regulated in the lung tissues of ALI mice and LPS‐induced RAW264.7 cells. circVAPA over‐expression alleviated lung tissue injury and dampened LPS‐induced pyroptosis and Th17‐associated inflammatory responses. miR‐212‐3p was identified as a target of circVAPA, and miR‐212‐3p negatively regulated the expression of Sirt1. Sirt1 knockdown largely abolished the effect of circVAPA over‐expression on pyroptosis. CircVAPA/miR‐212‐3p/Sirt1 axis also regulates Nrf2 and NLRP3 expression upon LPS challenge. By targeting miR‐212‐3p, circVAPA over‐expression negatively regulates the expression of Sirt1 and pyroptosis‐related factors (Nrf2 and NLRP3), which alleviates the inflammatory damages in sepsis‐induced ALI.
Three‐dimensional representation of the Vita Toothguide 3D‐Master: An in vivo clinical study
Authors: Gómez‐Polo Cristina , Fraile Javier Flores , López Norberto Quispe , Muñoz Maria Portillo , Lobato Maria , Montero Javier 
Published: December 2023

AbstractStatement of ProblemThe Vita Toothguide 3D‐Master (Vita Zahnfabrik) is considered the dental shade guide in which the three dimensions of color – lightness, hue, and chroma – are most well‐ordered in the CIELAB color space. No research has yet explored how well the Vita Toothguide 3D‐Master is ordered in the 3D color space by recording color coordinates in vivo.PurposeTo evaluate the spatial color distribution of the Vita Toothguide 3D‐Master's lightness, chroma, and hue groups and its 26 physical shade tabs.Materials and MethodsThe dental color (L*, C*, h°, a*, and b* color coordinates) of a healthy maxillary central incisor was recorded for 1361 participants (aged between 18 and 89 years) using a Vita Easyshade Compact spectrophotometer (Vita Zahnfabrik). The R 2.7.2. statistics program was used to create the visual representations.ResultsThe five lightness levels are those that are best distributed in the color space, in relation to the L* coordinates, followed by the chroma group and, finally, the hue group. The 5M1, 5M2, and 5M3 physical shade tabs are situated at a greater distance apart from the other tabs in the color space.ConclusionsThe Vita Toothguide 3D‐Master's 26 physical shade tabs are satisfactorily distributed in three‐dimensional space, although strict mathematical criteria are not followed. The natural dental shades that fall lower on the lightness scale are the most poorly represented by the physical shade tabs.Clinical ImplicationsDarker teeth are poorly represented by the Vita Toothguide 3D‐Master's physical shade tabs. The spatial distribution of dental shade guides needs to be improved to ensure they provide homogeneous coverage of the entire chromatic spectrum corresponding to natural teeth. This would help reduce the errors inherent to the subjective visual color selection process.
The association between orthodontic treatment and temporomandibular disorders diagnosis and disease characteristics
Authors: Shalish Miriam , Leibovich Avi , Zakuto Avraham , Slutzky Hulio , Chaushu Stella , Almoznino Galit 
Published: December 2023

AbstractBackgroundThe association between orthodontic treatment and temporomandibular disorders (TMD) has been contentious in the literature.ObjectivesTo analyse the associations between orthodontic treatment and TMD diagnosis and diseases characteristics.MethodsThis case–control study included 291 individuals, 192 TMDs and 99 controls. All patients underwent assessment based on a questionnaire and a clinical examination according to Axis I of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Differences in orthodontic treatment between TMDs and controls, as well as across different TMD diagnoses within the TMD group were analysed. Patients who underwent orthodontic treatment were compared to those who did not, regarding their trauma history, bruxism, aggressive teeth brushing, level of oral hygiene, pain scores, muscle tenderness scores and subjective sleep quality.ResultsOf the 291 participants, 119 (40.9%) underwent orthodontic treatment and 172 (59.1%) had no orthodontics experience. Orthodontic treatment included: mandibular orthodontic treatment (102 subjects) and maxillary orthodontic treatment (113 subjects) of those 47 used a headgear.Following multivariate analysis among TMDs, orthodontic treatment was associated with a good level of oral hygiene versus poor (Odds ratio [OR]: 5.17 [1.04–25.59]), lower number of tender muscles [OR = 0.84 (0.74–0.96)] and lower (better) Pittsburgh Sleep Quality Index (PSQI) scores (OR = 0.86 [0.76–0.97]). None of the studied parameters maintained a statistically significant association with orthodontic treatment in the multivariate analysis among the entire study population.ConclusionsUtilising a holistic approach, this study supports the main hypothesis that orthodontic treatment is not associated with TMD diagnosis and disease characteristics.
Dietary effects of microalga Tetraselmis suecica on growth, antioxidant‐immune activity, inflammation cytokines, and resistance of Nile tilapia fingerlings to Aeromonas sobria infection
Authors: Abdel‐Tawwab Mohsen , Khalil Riad H. , Abdel‐Razek Nashwa , Younis Nehal A. , Shady Sherien H. H. , Monier Mohamed N. , Abdel‐Latif Hany M. R. 
Published: December 2023

AbstractThe dietary effects of the green microalga Tetraselmis suecica (TS) on the growth, digestive enzymes, immune and antioxidant responses, genes expression, and disease resistance of Nile tilapia (Oreochromis niloticus) fingerlings were investigated. This microalga was mixed with the diet' ingredients at doses of 0.0 (the control), 5, 10, 15, and 20 g/kg diet and then fed to fish daily for 84 days. After the feeding trial, fish were experimentally challenged with Aeromonas sobria, infection and fish mortalities were recorded for another 10 days. Dietary TS significantly (p < 0.05) enhanced growth, digestive enzymes activities, and blood proteins, particularly at the level of 15 g/kg diet. Feeding the fish on 15 TS/kg feed exhibited highest mRNA expressions of GH and IGF‐1 genes as well as SOD, CAT, and GPx genes compared to other TS groups. Moreover, highest levels of hepatic antioxidant and immune indices were found in the treatment of 15 g TS/kg feed. Significant downregulation of IL‐1β and IL‐8 genes expression and significant upregulation of IL‐10 gene expression were observed in TS‐fed fish, principally in fish groups fed on 15−20 g TS/kg feed. Conversely, hepatic malondialdehyde levels, blood glucose, and the activities of transaminases (ALT and AST) were significantly (p < 0.05) decreased in fish fed with 15−20 g TS/kg diet. Serum bactericidal activity against A. sobria was significantly higher in TS‐fed fish groups, and its highest levels were found in treatments of 15−20 g/kg diet. Of interest, the survival rates of fish groups fed diets with 10−20 g TS/kg feed were higher after the challenge with A. sobria infection than the control group. Accordingly, we can conclude that supplementing fish diets with a 15 g TS/kg diet enhanced the growth, antioxidant and immune activities, and resistance of Nile tilapia fingerlings to possible A. sobria infection.