bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dynamics of Land Rents in Housing Submarkets: A Marxian Perspective
Authors: Park Joon 
Published: November 2023

AbstractThis theoretical study delves into the dynamics of housing submarkets with the framework of Marxian land rents. It examines the relationship between residential spaces and the reproduction of labour power in terms of commuting and the differentiated quality of reproduction by submarket. This study shows that the differentiation process of venturing to create distinct spaces for surplus profit and the emulation process of copycatting spaces of higher rents consequently form multiple housing submarkets, each characterised by different land rents of monopoly, intra‐differential rent (intra‐DR) and inter‐differential rent (inter‐DR). The coexistence of these multiple layers of land rents, in turn, becomes a driving force propelling dynamic capital movements that seek to exploit rent gaps between the layers. To illustrate these concepts, the study reviews the case of high‐rise mixed‐use residential developments in Seoul, highlighting the dual dynamic processes through which land rents are pursued.
Two levels in the feeling of familiarity
Authors: Lisco Sonia Maria , Ervas Francesca 
Published: November 2023

AbstractThis paper explores the role of phenomenology in the understanding of the cognitive processes of coupling/decoupling, defending the Wittgensteinian idea that phenomenology can play a crucial role as a description of immediate (social) experience. We argue that epistemic feelings can provide a phenomenological description of the development of a subject's everyday experience, tracking the transition from the processes of coupling/decoupling and recoupling with the world. In particular, the feeling of familiarity, whose key features can be considered the core of epistemic feelings, signals a novelty in the flow of experience that makes sense and is worthy of remarking on or even articulating. By describing the primary features and sources of the feeling of familiarity, we highlight a conceptual tension related to its sources, which could be based on processing both fluency and discrepancy. We proposed a solution to the conceptual tension by introducing two levels of the feeling of familiarity: epistemic and experiential.
Rice tetraspanins express in specific domains of diverse tissues and regulate plant architecture and root growth
Authors: Qin Shanshan , Li Wei , Zeng Jiayue , Huang Yifan , Cai Qiang 
Published: November 2023

SUMMARYTetraspanins (TETs) are small transmembrane scaffold proteins that distribute proteins into highly organized microdomains, consisting of adaptors and signaling proteins, which play important roles in various biological events. In plants, understanding of tetraspanin is limited to the Arabidopsis TET genes' expression pattern and their function in leaf and root growth. Here, we comprehensively analyzed all rice tetraspanin (OsTET) family members, including their gene expression pattern, protein topology, and subcellular localization. We found that the core domain of OsTETs is conserved and shares a similar topology of four membrane‐spanning domains with animal and plant TETs. OsTET genes are partially overlapping expressed in diverse tissue domains in vegetative and reproductive organs. OsTET proteins preferentially targeted the endoplasmic reticulum. Mutation analysis showed that OsTET5, OsTET6, OsTET9, and OsTET10 regulated plant height and tillering, and that OsTET13 controlled root growth in association with the jasmonic acid pathway. In summary, our work provides systematic new insights into the function of OsTETs in rice growth and development, and the data provides valuable resources for future research.
Symmetric polynomials in free center-by-metabelian Lie algebras of rank 2
Authors: Kofinas C. E. 
Published: November 2023

Let [Formula: see text] be the free center-by-metabelian Lie algebra of rank 2 freely generated by the set [Formula: see text]. Let [Formula: see text] be the Lie subalgebra of symmetric polynomials in [Formula: see text], that is, [Formula: see text] consists of all the elements [Formula: see text] in [Formula: see text] such that [Formula: see text]. We give a linear basis and a minimal infinite generating set for [Formula: see text], thus extending results of Ş. Findik and N. Ögüşlü [Palindromes in the free metabelian Lie algebras, Internat. J. Algebra Comput. 29(5) (2019) 885–891].
Absence of BTK, BCL2, and PLCG2 Mutations in Chronic Lymphocytic Leukemia Relapsing after First-Line Treatment with Fixed-Duration Ibrutinib plus Venetoclax
Authors: Jain Nitin , Croner Lisa J. , Allan John N. , Siddiqi Tanya , Tedeschi Alessandra , Badoux Xavier C. , Eckert Karl , Cheung Leo W.K. , Mukherjee Anwesha , Dean James P. , Szafer-Glusman Edith , Seymour John F. 
Published: November 2023

Abstract

Purpose:
Mutations in BTK, PLCG2, and BCL2 have been reported in patients with progressive disease (PD) on continuous single-agent BTK or BCL2 inhibitor treatment. We tested for these mutations in samples from patients with PD after completion of first-line treatment with fixed-duration ibrutinib plus venetoclax for chronic lymphocytic leukemia (CLL) in the phase II CAPTIVATE study.

Patients and Methods:
A total of 191 patients completed fixed-duration ibrutinib plus venetoclax (three cycles of ibrutinib then 12–13 cycles of ibrutinib plus venetoclax). Genomic risk features [del(11q), del(13q), del(17p), trisomy 12, complex karyotype, unmutated IGHV, TP53 mutated] and mutations in genes recurrently mutated in CLL (ATM, BIRC3, BRAF, CHD2, EZH2, FBXW7, MYD88, NOTCH1, POT1, RPS15, SF3B1, XPO1) were assessed at baseline in patients with and without PD at data cutoff; gene variants and resistance-associated mutations in BTK, PLCG2, or BCL2 were evaluated at PD.

Results:
Of 191 patients completing fixed-duration ibrutinib plus venetoclax, with median follow-up of 38.9 months, 29 (15%) developed PD. No baseline risk feature or gene mutation was significantly associated with development of PD. No previously reported resistance-associated mutations in BTK, PLCG2, or BCL2 were detected at PD in 25 patients with available samples. Of the 29 patients with PD, 19 have required retreatment (single-agent ibrutinib, n = 16, or ibrutinib plus venetoclax, n = 3); 17 achieved partial response or better, 1 achieved stable disease, and 1 is pending response assessment.

Conclusions:
First-line fixed-duration combination treatment with ibrutinib plus venetoclax may mitigate development of resistance mechanisms associated with continuous single-agent targeted therapies, allowing for effective retreatment.
See related commentary by Al-Sawaf and Davids, p. 471
Basigin Deficiency Induces Spontaneous Polycystic Kidney in Mice
Authors: Zhong Fangyuan , Li Wenli , Zhao Chenxu , Jin Lixing , Lu Xiyuan , Zhao Yichao , Pu Jun , Ge Heng 
Published: November 2023

BACKGROUND:
Polycystic kidney disease is the most common hereditary kidney disorder with early and frequent hypertension symptoms. The mechanisms of cyst progression in polycystic kidney disease remain incompletely understood.

METHODS:
Bsg (basigin) heterozygous and homozygous knockout mice were generated using cas9 system, and Bsg overexpression was achieved by adeno-associated virus serotype 9 injection. Renal morphology was investigated through histological and imaging analysis. Molecular analysis was performed through transcriptomic profiling and biochemical approaches.

RESULTS:
Bsg-deficient mice exhibited significantly elevated arterial blood pressure. Further investigation demonstrated that Bsg deficiency triggers spontaneous cystic formation in mouse kidneys, which shares similar cyst pathological features and common transcriptional regulatory pathways with human polycystic kidney disease. Moreover, Bsg disruption promoted polycystin-1 ubiquitination and degradation, leading to activation of polycystic kidney disease associated cAMP and AMPK signaling pathways in Bsg knockout mouse kidneys. Finally, adeno-associated virus serotype 9 mediated Bsg reexpression reversed cystic progression in Bsg knockout mice in vivo, and Bsg overexpression inhibited the expansion of Madin-Darby canine kidney cysts in vitro.

CONCLUSIONS:
Our findings show that Bsg deficiency leads to an early-onset spontaneous polycystic kidney phenotype, suggesting that dysregulated Bsg signaling may be a contributing factor in cystogenesis.
Burden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the GBD Study 2019
Authors: Aminorroaya Arya , Saeedi Moghaddam Sahar , Tavolinejad Hamed , Aryan Zahra , Heidari Behnam , Ebrahimi Hedyeh , Naderian Mohammadreza , Shobeiri Parnian , Ghanbari Ali , Rezaei Nazila , Malekpour Mohammad‐Reza , Haghshenas Rosa , Rezaei Negar , Larijani Bagher , Farzadfar Farshad 
Published: November 2023

Background
The North Africa and Middle East (NAME) region has one of the highest burdens of ischemic heart disease (IHD) worldwide. This study reports the contemporary epidemiology of IHD in NAME.

Methods and Results
We estimated the incidence, prevalence, deaths, years of life lost, years lived with disability, disability‐adjusted life years (DALYs), and premature mortality of IHD, and its attributable risk factors in NAME from 1990 to 2019 using the results of the GBD (Global Burden of Disease study 2019). In 2019, 0.8 million lives and 18.0 million DALYs were lost due to IHD in NAME. From 1990 to 2019, the age‐standardized DALY rate of IHD significantly decreased by 33.3%, mostly due to the reduction of years of life lost rather than years lived with disability. In 2019, the proportion of premature death attributable to IHD was higher in NAME compared with global measures: 26.8% versus 16.9% for women and 18.4% versus 14.8% for men, respectively. The age‐standardized DALY rate of IHD attributed to metabolic risks, behavioral risks, and environmental/occupational risks significantly decreased by 28.7%, 37.8%, and 36.4%, respectively. Dietary risk factors, high systolic blood pressure, and high low‐density lipoprotein cholesterol were the top 3 risks contributing to the IHD burden in most countries of NAME in 2019.

Conclusions
In 2019, IHD was the leading cause of death and lost DALYs in NAME, where premature death due to IHD was greater than the global average. Despite the great reduction in the age‐standardized DALYs of IHD in NAME from 1990 to 2019, this region still had the second‐highest burden of IHD in 2019 globally.
Synchrony in auditory 40-Hz gamma oscillations increases in older age and correlates with hearing abilities and cortical GABA levels
Authors: Dobri Simon , Chen J. Jean , Ross Bernhard 
Published: November 2023

Abstract
Synchronized 40-Hz gamma oscillations in specific sensory and higher-order thalamocortical networks provide a neural mechanism for feature binding. Aging-related changes in gamma oscillations may cause deficits in auditory feature binding, contributing to impaired speech-in-noise perception. Gamma synchrony is controlled through inhibitory mechanisms mediated by the neurotransmitter γ-aminobutyric acid (GABA), which has been shown to decline in aging. This study investigated aging-related changes in gamma oscillations and how they relate to auditory function and cortical GABA levels. Magnetoencephalograms of 40-Hz auditory steady-state responses (ASSRs) were recorded in young and older adults by presenting amplitude-modulated tones in quiet and mixed with concurrent multi-talker babble noise. Responses in the quiet condition had longer latencies and more prominent amplitudes, indicating the 40-Hz ASSRs in noise were dominated by a sensory component and in quiet by a component involved in higher-order processing. The ASSR amplitudes increased in older adults under both stimulus conditions. However, larger ASSR amplitudes were associated with more severe hearing and speech-in-noise loss only in the noise condition. This suggests the aging-related increase in synchrony of sensory gamma oscillations has a detrimental effect on auditory processing. It may cause increased interference between competing sounds in the central auditory system, making it difficult for the aging auditory system to separate speech features from noise and bind them into a distinct perceptual object. Also in older adults, larger amplitudes of the 40-Hz ASSRs in the quiet condition were associated with higher left auditory cortex GABA concentrations measured with magnetic resonance spectroscopy, supporting GABA’s role in internally generated gamma synchrony in aging.
Directional sensitivity of cortical neurons towards TMS-induced
electric fields
Authors: Weise Konstantin , Worbs Torge , Kalloch Benjamin , Souza Victor H. , Jaquier Aurélien Tristan , Van Geit Werner , Thielscher Axel , Knösche Thomas R. 
Published: November 2023

Abstract
We derived computationally efficient average response models of different types of cortical neurons, which are subject to external electric fields from Transcranial Magnetic Stimulation. We used 24 reconstructions of pyramidal cells (PC) from layer 2/3, 245 small, nested, and large basket cells from layer 4, and 30 PC from layer 5 with different morphologies for deriving average models. With these models, it is possible to efficiently estimate the stimulation thresholds depending on the underlying electric field distribution in the brain, without having to implement and compute complex neuron compartment models. The stimulation thresholds were determined by exposing the neurons to TMS-induced electric fields with different angles, intensities, pulse waveforms, and field decays along the somato-dendritic axis. The derived average response models were verified by reference simulations using a high-resolution realistic head model containing several million neurons. The relative errors of the estimated thresholds between the average model and the reference model ranged between -3% and 3.7% in 98% of the cases, while the computation time was only a fraction of a second compared to several weeks. Finally, we compared the model behavior to TMS experiments and observed high correspondence to the orientation sensitivity of motor evoked potentials. The derived models were compared to the classical cortical column cosine model and to simplified ball-and-stick neurons. It was shown that both models oversimplify the complex interplay between the electric field and the neurons and do not adequately represent the directional sensitivity of the different cell types. The derived models are simple to apply and only require the TMS-induced electric field in the brain as input variable. The models and code are available to the general public in open-source repositories for integration into TMS studies to estimate the expected stimulation thresholds for an improved dosing and treatment planning in the future.
Racialization and International Security
Authors: Maass Richard W. 
Published: November 2023

Abstract
Racialization—the processes that infuse social and political phenomena with racial identities and implications—is an assertion of power, a claim of purportedly inherent differences that has saturated modern diplomacy, order, and violence. Despite the field's consistent interest in power, international security studies in the United States largely omitted racial dynamics from decades of debates about international conflict and cooperation, nuclear proliferation, power transitions, unipolarity, civil wars, terrorism, international order, grand strategy, and other subjects. A new framework lays conceptual bedrock, links relevant literatures to major research agendas in international security, cultivates interdisciplinary dialogues, and charts promising paths to consider how overt and embedded racialization shape the study and practice of international security. A discussion of several research design challenges for integrating racialization into existing and new research agendas helps scholars reconsider how they approach questions of race and security. Beyond diversifying the professoriat itself, revealing and countering embedded biases are crucial to determine how alternative ideas have been marginalized, and, ultimately, to develop better theories.
Wiidookaage’Win: A Community-Based Qualitative Approach to Developing a Facebook Group Intervention for Native Women to Support Recovery From Opioid Use
Authors: Young Antonia , Sinicrope Pamela , Kelpin Sydney , Roche Anne I. , Sabaque Corinna , Pham Cuong , Marsch Lisa A , Campbell Aimee N. C. , Venner Kamilla , Bastian Emily , Nord Teresa , Mason Gail , Baker Laiel , Wyatt Thomas , Fish Amy , Bart Gavin , Patten Christi A. 
Published: November 2023

Purpose To develop a culturally-tailored American Indian/Alaska Native (AI/AN) women’s Facebook group supporting opioid recovery as an adjunct to medication. Design Community-based, qualitative approach. Setting Minnesota, U.S. Participants AI/AN women in opioid recovery, interested parties, and a Community Advisory Committee (CAC) of AI/AN women with lived experience, health care providers, and community members. Intervention We developed evidence-based content focusing on stress/trauma and substance use, mindfulness, responding to triggers, and supportive community resources. Additional content centered on AI/AN culture was also selected. Method Interviews were conducted by two women, then transcribed and coded using content analysis with NVivo software. Results were presented to CAC for further content refinement. Results CAC members (n = 10) guided study methods, intervention development, and dissemination activities. 14 AI/AN women (mean age 36.4 years; mean 6.7 months opioid abstinence) and 12 interested parties (7 men, 5 women) were receptive to an AI/AN gender-specific Facebook group, preferring content with AI/AN people and/or text resonating with AI/AN culture (e.g., Native traditions, family, personal stories, historical trauma). Recommendations included (1) protect confidentiality, (2) retain positivity, (3) incorporate resources and exercises to build coping skills, and (4) moderators should be authentic and relatable to build trust. Conclusions Our approach provides a model for developing culturally tailored, appealing and effective social media interventions to support AI/AN women in recovery from opioid use disorder.
Effectiveness of Patiromer Versus Sodium Zirconium Cyclosilicate for the Management of Acute Hyperkalemia
Authors: Rydell Alison , Thackrey Corianne , Molki Maryam , Mullins Brandon P. 
Published: November 2023

Background: Patiromer and sodium zirconium cyclosilicate (SZC) are 2 oral potassium binders approved for chronic hyperkalemia. It is unknown if one is more effective at reducing serum potassium than the other in acute hyperkalemia. Objective: The objective of this study was to determine if there was a difference between patiromer and SZC in the reduction of serum potassium in patients with acute hyperkalemia. Methods: This was a single-center, retrospective, observational study. Patients with a nonhemolyzed serum potassium level of 5.5 mEq/L or greater and received at least one dose of patiromer or SZC were included. The primary outcome was to determine the difference in effectiveness between patiromer and SZC in lowering of serum potassium 6 to 24 hours after administration. Secondary outcomes included description of total dosage received in 24 hours and incidence of electrolyte changes. Results: A total of 200 patients were included in this study, with 100 patients in each group. Serum potassium was significantly reduced by both patiromer (−1.2 mEq/L, 95% confidence interval [CI]: −2.3 to −0.2) and SZC (−0.8 mEq/L, 95% CI: −1.0 to −0.7), but there was no difference between the 2 medications in the amount of potassium reduction ( P = 0.464). No clinically significant differences in electrolyte changes were seen. Conclusions and Relevance: This study represents the first head-to-head comparison of patiromer and SZC in the setting of acute hyperkalemia. No difference in effectiveness between patiromer and SZC in reducing serum potassium was seen. Both agents can be considered in acute hyperkalemia management.
The Sesquiterpene, Selin-11-en-4α-ol, from Artemisia vulgaris Inhibits Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Cells via MAPK and NF-κB Signaling Pathways
Authors: Wei Ning , Dong Wanwen , Liu Tao , Guo Yuying , Liang Feng , You Yuejiao , Ye Cuifang , Wang Yifei , Wang Qiaoli , Wang Zhiping 
Published: November 2023

Objective Our study aimed to investigate the underlying molecular mechanisms of selin-11-en-4α-ol purified from Artemisia vulgaris against anti-inflammation through network pharmacology, molecular docking, and in vitro experiments. Methods Potential targets for selin-11-en-4α-ol and inflammation were obtained using Swiss Target Prediction, Pharm Mapper, and GeneCards databases. Venn diagrams were used to obtain the targets of selin-11-en-4α-ol for the treatment of inflammation, and the intersecting targets were uploaded to the STRING database to construct a protein–protein interaction (PPI) network of selin-11-en-4α-ol anti-inflammatory target proteins for further screening of the core targets. The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted using the DAVID database. In addition, molecular docking validation of core target binding to selin-11-en-4α-ol was performed. The anti-inflammatory effects were verified by in vitro experiments of lipopolysaccharide-induced RAW264.7 cells. Results PPI network analysis showed that mitogen-activated protein kinase 14 (MAPK14), SRC, and HSP90AA1 were predicted as potential anti-inflammatory targets, and KEGG enrichment analysis revealed that the MAPK signaling pathway presented the highest gene enrichment counts. Molecular docking and western blot results suggested that selin-11-en-4α-ol regulated MAPK and nuclear transcription factor-κB (NF-κB) signaling pathways to alleviate inflammation. In addition, selin-11-en-4α-ol inhibited the production of inflammatory factors, chemokines, and reactive oxygen species and exhibited anti-inflammatory and antioxidant effects. Conclusion Selin-11-en-4α-ol treats inflammation by targeting the MAPK and NF-κB signaling pathway, demonstrating that network pharmacology and molecular docking are effective tools for studying traditional Chinese medicine and providing a theoretical basis for developing anti-inflammatory drugs.