bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond the outdoors: indoor air quality guidelines and standards – challenges, inequalities, and the path forward
Authors: Siddique Azhar , Al-Shamlan Maryam Y. M. , Al-Romaihi Hamad E. , Khwaja Haider A. 
Published: December 2023

Abstract
In the last few decades, indoor air quality (IAQ) has become a major threat to public health. It is the fifth leading cause of premature death globally. It has been estimated that people spend ∼90 % of their time in an indoor environment. Consequently, IAQ has significant health effects. Although IAQ-related standards and guidelines, policies, and monitoring plans have been developed in a few countries, there remain several global inequalities and challenges. This review paper aims to comprehensively synthesize the current status of widely accepted IAQ guidelines and standards. It analyzes their global implementation and effectiveness to offer insights into challenges and disparities in IAQ policies and practices. However, the complexity of domestic environments and the diversity of international standards impede effective implementation. This manuscript evaluates international, national, and regional IAQ guidelines, emphasizing similarities and differences. In addition, it highlights knowledge gaps and challenges, urging the international scientific community, policymakers, and stakeholders to collaborate to advance IAQ standards and guidelines. The analysis evaluates the efficacy of guidelines, identifies deficiencies, and offers recommendations for the future of domestic air quality standards.
Comparative vascular effects of levetiracetam and valproate with hyperhomocysteinemia in rat models
Authors: Gökdemir Selim , Todurga Seven Zeynep Gizem , Shahzadi Andleeb , Neşetoğlu Neşet , Ünal Durişehvar , Akkan Gökhan , Özyazgan Sibel 
Published: December 2023

Abstract

Objectives
Hyperhomocysteinemia (HHcy) a significant risk factor for vascular disease, often emerges in epilepsy with the use of antiepileptic drugs. In this relationship, our study investigates the combined effects of HHcy and antiepileptics on vascular function using a rat model.

Methods
Fourty two rats were included and divided into six groups as, 1-Control, 2-L-Met, 3-LEV injected, 4-LEV-injected + L-Met, 5-VAL-injected, 6-VAL injected + L-Met. L-Methionine (L-Met) was added to drinking water of rats for 1 month to develop HHcy. Simultaneously, intraperitoneal (ip) injections of sodium valproate (VAL) and levetiracetam (LEV) were administered. Effects were comparatively investigated, and noradrenaline (NA), followed by acetylcholine (ACh) and glyceryl trinitrate (GTN) were applied in organ bath system. Agonist doses were expressed as ten base logarithm (M) through 10−9, 10−8, 10−7, 10−6, 10−5, 10−4 mol/L in dose-response graph.

Results
NA contractions between LEV and LEV + L-Met groups showed statistical significance (LEV Emax=288.50 ± 46.54, LEV + L-Met Emax=480.40 ± 78.83) (p<0.05) however, no significance was observed among the other groups. ACh relaxations between Control-L-Met (Control Inhmax=12.65 ± 2.09, L-Met Inhmax=50.05 ± 7.43) (p<0.05), and Control-Val + L-Met (Control Emax=328.20 ± 52.83, VAL + L-Met Emax=452.60 ± 71.53) (p<0.01), groups showed statistical significance. Between other groups, no significance was observed. In GTN relaxations, no statistical significance was observed.

Conclusions
This study highlights the adverse impact of HHcy on aortic relaxation. Further impairment was observed with VAL compared to other treatment and control groups. These findings underscore the importance of considering vascular side effects when selecting antiepileptic drugs. Ultimately, our study contributes valuable insights that may aid the choice of appropriate treatment strategies to mitigate potential vascular complications of HHcy.
Dynamic Foraging Behavior Performance Is Not Affected byScn2aHaploinsufficiency
Authors: Schamiloglu Selin , Wu Hao , Zhou Mingkang , Kwan Alex C. , Bender Kevin J. 
Published: December 2023

AbstractDysfunction in the geneSCN2A, which encodes the voltage-gated sodium channel Nav1.2, is strongly associated with neurodevelopmental disorders including autism spectrum disorder and intellectual disability (ASD/ID). This dysfunction typically manifests in these disorders as a haploinsufficiency, where loss of one copy of a gene cannot be compensated for by the other allele.Scn2ahaploinsufficiency affects a range of cells and circuits across the brain, including associative neocortical circuits that are important for cognitive flexibility and decision-making behaviors. Here, we tested whetherScn2ahaploinsufficiency has any effect on a dynamic foraging task that engages such circuits.Scn2a+/−mice and wild-type (WT) littermates were trained on a choice behavior where the probability of reward between two options varied dynamically across trials and where the location of the high reward underwent uncued reversals. Despite impairments inScn2a-related neuronal excitability, we found that both male and femaleScn2a+/−mice performed these tasks as well as wild-type littermates, with no behavioral difference across genotypes in learning or performance parameters. Varying the number of trials between reversals or probabilities of receiving reward did not result in an observable behavioral difference, either. These data suggest that, despite heterozygous loss ofScn2a, mice can perform relatively complex foraging tasks that make use of higher-order neuronal circuits.
Influence of Stress Resistance on Myocardial Expression of the Pro-Autophagic Protein Beclin-1 After Cardiac Contusion in Experimental Setting
Authors: Klyuchnikova E. I. , Korpacheva O. V. , Mozgovoy S. I. , Zolotov A. N. , Kononov A. V. 
Published: December 2023

Objective. Evaluation of myocardial expression of the pro-autophagic protein Beclin-1 after cardiac contusion in experimental animals with diﬀerent stress resistance.Materials and methods. The study included 68 white mongrel male rats weighing 250–300 g. After ranking for extreme variants of stress resistance, moderately stress-resistant rats (N=36) were excluded from the study. The remaining animals were split into the control (N=16) and study (N=16) groups, each group composed of 8 high stress resistant and 8 low stress resistant rats. In the study group, 24 hours after inﬂicted cardiac contusion, 5×5 mm myocardial tissue specimens were sampled from the intraventricular septum, anterior walls of the left and right ventricles, histological sections were made, and a reaction with primary polyclonal Anti-Beclin-1 antibodies was performed. Beclin-1 expression was evaluated under the microscope.Results. Immunohistochemical evaluation revealed a statistically signiﬁcant increase in Beclin-1 protein expression (P=0.0002) in the cytoplasm of cardiomyocytes in the study group vs the control group, regardless of animals’ baseline stress resistance. However, expression of Beclin-1 protein in the myocardium of highly stress-resistant rats (Me=4.3; LQ=4.0; HQ=4.3) was signiﬁcantly higher versus low-resistant animals (Me=3.6; LQ=3.3; HQ=3.6) (P=0.0009).Conclusion. Increased expression of Beclin-1 protein in the post-traumatic period of experimental cardiac contusion indicates autophagic ﬂux activation. Intensity of autophagy varied depending on the animal’s stress resistance.
GRACEFUL CHROMATIC NUMBER OF SOME CARTESIAN PRODUCT GRAPHS
Authors: Suparta I Nengah , Venkatachalam Mathiyazhagan , Gunadi I Gede Aris , Pratama Putu Andi Cipta 
Published: December 2023

A graph \(G(V,E)\) is a system consisting of a finite non empty set of vertices \(V(G)\) and a set of edges \(E(G)\). A (proper) vertex colouring of \(G\) is a function \(f:V(G)\rightarrow \{1,2,\ldots,k\},\) for some positive integer \(k\) such that \(f(u)\neq f(v)\) for every edge \(uv\in E(G)\). Moreover, if \(|f(u)-f(v)|\neq |f(v)-f(w)|\) for every adjacent edges \(uv,vw\in E(G)\), then the function \(f\) is called graceful colouring for \(G\). The minimum number \(k\) such that \(f\) is a graceful colouring for \(G\) is called the graceful chromatic number of \(G\). The purpose of this research is to determine graceful chromatic number of Cartesian product graphs \(C_m \times P_n\) for integers \(m\geq 3\) and \(n\geq 2\), and \(C_m \times C_n\) for integers \(m,n\geq 3\). Here, \(C_m\) and \(P_m\) are cycle and path with \(m\) vertices, respectively. We found some exact values and bounds for graceful chromatic number of these mentioned Cartesian product graphs.
Estrategias emergentes del Offshoring en la Gestión de la Cadena de Suministros Global
Authors: Mamani Perez Jazmín , Segura Montañez Leonardo 
Published: December 2023

Después de que la crisis del Covid-19 haya interrumpido la cadena de suministros a nivel global, las empresas, están considerando trasladar sus operaciones a otras zonas geográficas, es decir, realizar una deslocalización para reestructurar su huella de producción a nivel mundial. Debido a esto el offshoring se está convirtiendo en una respuesta estratégica para reducir el riesgo geográfico y aumentar la resiliencia ante posibles crisis futuras, por lo cual esta estrategia de la deslocalización puede verse impulsado por factores como la reducción de costos, el acceso a talento especializado y la necesidad de optimizar las cadenas de suministro a escala global. El objetivo de la presente investigación consiste en analizar el comportamiento de la implementación de las estrategias del offshoring empresarial en la gestión de cadena de suministros, para luego establecer ciertas recomendaciones hacia aquellas empresas que no utilizan estas estrategias en especial en América Latina. El modelo de investigación es una revisión sistemática enfocado en los beneficios de las estrategias del offshoring implementadas por las empresas. Para tal efecto, se planteó una búsqueda en dos fuentes: Scopus y Web of Science (WoS) y un análisis siguiendo el método PRISMA. Asimismo, se presenta como resultados 11 beneficios de las estrategias del offshoring que las organizaciones implementan para reestructurar su huella de producción a nivel global. Este estudio concluye con 7 razones principales de la implementación de las estrategias del offshoring en las empresas, de las cuales son: la reducción de costos de producción, el acceso al mercado del país extranjero, la implementación de precios de transferencia, el ahorro de menores costos laborales, el contrato de trabajadores altamente calificados, el acceso a nuevas tecnologías y conocimientos y la reducción o diversificación de riesgos que ayudaron a las organizaciones a optimizar sus costos y reestructurar los recursos estratégicos. Por esta razón se recomienda a las empresas de dichos países de América Latina que utilicen estas estrategias que le ayudaran a generar una ventaja competitiva en la cadena de suministros haciéndolo más compleja, eficiente, ágil, productiva y competitiva en los mercados exteriores.
Bibliometric analysis of articles published in Cukurova Medical Journal between 2011 and 2022
Authors: ÖZANDAÇ POLAT Sema , TUNÇ Mahmut , ÖZŞAHİN Esin , TAMAM Lut , GÖKER Pınar 
Published: December 2023

Purpose: This study aimed to perform a bibliometric analysis of the abstracts and keywords in articles published in the Cukurova Medical Journal from 2011 to 2022.
Materials and Methods: We compiled and analyzed all articles published in the Cukurova Medical Journal between 2011 and 2022, totaling 1734 articles, using VOSviewer software (version 1.6.19). This analysis focused on the terms in the abstracts and the keywords of these articles.
Results: The study identified 27,409 unique terms and 4,040 unique keywords in the abstracts of the 1734 articles. The most common terms were 'surgery' (333 occurrences), 'pain' (263), 'infection' (201), 'measurement' (192), 'rat' (185), 'tumor' (177), 'covid' (157), 'pregnancy' (148), 'questionnaire' (144), and 'drug' (142). The top keywords were 'children' (43 occurrences), 'quality of life' (37), 'covid-19' (34), 'nursing' (32), 'pregnancy' (28), 'depression' (27), 'mortality' (26), 'anxiety' (24), 'child' (22), and 'obesity' (17).
Conclusion: This is the first bibliometric analysis of keywords and terms used in the Cukurova Medical Journal, offering insights into the evolving topics of interest in the journal's publications. It also provides valuable information for researchers looking to submit articles to the journal, highlighting prevalent themes and content areas.
Modeling of human placental capillaries by using a unique 3d reconstruction program
Authors: AYRAN FİDAN Pınar 
Published: December 2023

Purpose: Visualization of the three-dimensional structures is performed by examining two-dimensional sections in histology. It is not always possible to comprehend structure-function integrity. Therefore, it was planned to obtain three-dimensional (3D) models of the capillaries in the placenta terminal villus by using the program developed in the Başkent University’s laboratory and used in studies in different disciplines. The program’s suitability for histology studies will also be assessed.
Materials and Methods: A term placenta tissue sample was obtained from a 33-year-old healthy woman. Following the plastic embedding procedure, semi-thin serial sections were taken from these blocks. The sections were stained using toluidine blue and examined and photographed by using a light microscope. The 3D modeling procedure was conducted on the light micrographs of serial sections in order to reconstruct villous capillaries.
Results: 3D images were obtained from two-dimensional light micrographs by using the same program. It was determined that the vessels running parallel to each other branched harmoniously, forming a capillary network in the terminal villus. Additionally, challenges encountered during the utilization of this program in histological studies are also presented in this study.
Conclusion: Fetal blood reaches every part of the terminal villus through the branching capillary network. This feature would increase the surface area of vasculo-syncytial membrane and facilitate feto-maternal exchange. This can be clearly visualized by using 3D models. Three-dimensional modeling helps to understand the structure of all organs and tissues. Given that the current program is freely accessible, it will not incur additional costs for researchers and is open to further improvement by the programmer (erhankiziltan@gmail.com).
Effects of sleeve gastrectomy on N6-methyladenosine modification in duodenal tissue
Authors: ARSLAN Badel , SEYİT Hakan , AKYÜREK Murat Eser , ARSLAN Serdal , SAKIZ Damlanur , TÜRKSEVEN Çağatay Han 
Published: December 2023

Purpose. In this study, the expression levels of METTL3, METTL14; and WTAP genes involved in the N6-methyladenosine (m6A) pathway, regulating cellular processes including cell renewal, differentiation, invasion; and apoptosis, were investigated in duodenal tissue after sleeve gastrectomy (SG).
Material and Methods: Duodenal biopsies were obtained from 24 obese patients before (BG) and 6 months after (AG) sleeve gastrectomy. Pathological evaluation was performed by H&E staining. Expression levels of METTL14, METTL3, and WTAP genes were analysed by Real-Time PCR.
Results: The METTL14 gene was significantly increased after surgery (BG-AG Median (Q1-Q3): 0.36 [0.07-1.52]-9.83 [0.20-68.12]). METTL3 (BG-AG Median (Q1-Q3): 0.49 [0.32-0.84]-0.67 [0.36-20.5]) and WTAP (BG-AG Median (Q1-Q3): 0.95 [0.17-7.65]-5.54 [2.34-66.07]) gene expressions were not altered. However, a strong positive (r=0.692) and significant relationship was found between METTL3 and WTAP. Chronic inflammation 81.32 %, intestinal metaplasia 10.54 %, activity 68.88 %, atrophy 5.32 %. No malignant findings were detected.
Conclusion: For the first time, we demonstrated that sleeve gastrectomy may increase the expression of the METTL14 gene involved in the m6A-methyladenosine pathway in duodenum. This alteration may lead to gastrointestinal tract diseases.
Hydrologic Impacts of a Strike-Slip Fault Zone: Insights from Joint 3D Body-Wave Tomography of Rock Valley
Authors: Harding Jennifer L. , Preston Leiph A. , Bodmer Miles A. 
Published: December 2023

ABSTRACT
The Rock Valley fault zone (RVFZ), an intraplate strike-slip fault zone in the southern Nevada National Security Site (NNSS), hosted a series of very shallow (&lt;3 km) earthquakes in 1993. The RVFZ may also have hydrological significance within the NNSS, potentially playing a role in regional groundwater flow, but there is a lack of local hydrological data. In the Spring of 2021, we collected active-source accelerated weight drop seismic data over part of the RVFZ to better characterize the shallow subsurface. We manually picked ∼17,000 P-wave travel times and over 14,000 S-wave travel times, which were inverted for P-wave velocity (VP), S-wave velocity (VS), and VP/VS ratio in a 3D joint tomographic inversion scheme. Seismic velocities are imaged as deep as ∼700 m in areas and generally align with geologic and structural expectations. VP and VS are relatively reduced near mapped and inferred faults, with the most prominent lower VP and VS zone around the densest collection of faults. We image VP/VS ratios ranging from ∼1.5 to ∼2.4, the extremes of which occur at a depth of ∼100 m and are juxtaposed across a fault. One possible interpretation of the imaged seismic velocities is enhanced fault damage near the densest collection of faults with relatively higher porosity and/or crack density at ∼100 m depth, with patches of semiperched groundwater present in the sedimentary rock in higher VP/VS areas and drier rock in lower VP/VS areas. A relatively higher VP/VS area beneath the densest faults persists at depth, which suggests percolation of groundwater via the fault damage zone to the regionally connected lower carbonate aquifer. Potentially, the presence and movement of groundwater may have played a role in the 1993 earthquake aftershocks.
The Ground-Motion Characterization Model for the 2022 New Zealand National Seismic Hazard Model
Authors: Bradley Brendon A. , Bora Sanjay S. , Lee Robin L. , Manea Elena F. , Gerstenberger Matthew C. , Stafford Peter J. , Atkinson Gail M. , Weatherill Graeme , Hutchinson Jesse , de la Torre Christopher A. , Hulsey Anne M. , Kaiser Anna E. 
Published: December 2023

ABSTRACT
This article summarizes the ground-motion characterization (GMC) model component of the 2022 New Zealand National Seismic Hazard Model (2022 NZ NSHM). The model development process included establishing a NZ-specific context through the creation of a new ground-motion database, and consideration of alternative ground-motion models (GMMs) that have been historically used in NZ or have been recently developed for global application with or without NZ-specific regionalizations. Explicit attention was given to models employing state-of-the-art approaches in terms of their ability to provide robust predictions when extrapolated beyond the predictor variable scenarios that are well constrained by empirical data alone. We adopted a “hybrid” logic tree that combined both a “weights-on-models” approach along with backbone models (i.e., metamodels), the former being the conventional approach to GMC logic tree modeling for NSHM applications using published models, and the latter being increasingly used in research literature and site-specific studies. In this vein, two NZ-specific GMMs were developed employing the backbone model construct. All of the adopted subduction GMMs in the logic tree were further modified from their published versions to include the effects of increased attenuation in the back-arc region; and, all but one model was modified to account for the reduction in ground-motion standard deviations as a result of nonlinear surficial site response. As well as being based on theoretical arguments, these adjustments were implemented as a result of hazard sensitivity analyses using models without these effects, which we consider gave unrealistically high hazard estimates.
The 2022 Aotearoa New Zealand National Seismic Hazard Model: Process, Overview, and Results
Authors: Gerstenberger Matthew C. , Bora Sanjay , Bradley Brendon A. , DiCaprio Chris , Kaiser Anna , Manea Elena F. , Nicol Andy , Rollins Chris , Stirling Mark W. , Thingbaijam Kiran K. S. , Van Dissen Russ J. , Abbott Elizabeth R. , Atkinson Gail M. , Chamberlain Chris , Christophersen Annemarie , Clark Kate , Coffey Genevieve L. , de la Torre Chris A. , Ellis Susan M. , Fraser Jeff , Graham Kenny , Griffin Jonathan , Hamling Ian J. , Hill Matt P. , Howell A. , Hulsey Anne , Hutchinson Jessie , Iturrieta Pablo , Johnson Kaj M. , Jurgens V. Oakley , Kirkman Rachel , Langridge Rob M. , Lee Robin L. , Litchfield Nicola J. , Maurer Jeremy , Milner Kevin R. , Rastin Sepi , Rattenbury Mark S. , Rhoades David A. , Ristau John , Schorlemmer Danijel , Seebeck Hannu , Shaw Bruce E. , Stafford Peter J. , Stolte Andrew C. , Townend John , Villamor Pilar , Wallace Laura M. , Weatherill Graeme , Williams Charles A. , Wotherspoon Liam M. 
Published: December 2023

AbstractThe 2022 revision of Aotearoa New Zealand National Seismic Hazard Model (NZ NSHM 2022) has involved significant revision of all datasets and model components. In this article, we present a subset of many results from the model as well as an overview of the governance, scientific, and review processes followed by the NZ NSHM team. The calculated hazard from the NZ NSHM 2022 has increased for most of New Zealand when compared with the previous models. The NZ NSHM 2022 models and results are available online.
Cross-Regional Seismic Event Discrimination via Convolutional Neural Networks: Exploring Fine-Tuning and Ensemble Averaging
Authors: Kasburg Valentin , Müller Jozef , Eulenfeld Tom , Breuer Alexander , Kukowski Nina 
Published: December 2023

ABSTRACT
The gradual densification of seismic networks has facilitated the acquisition of large amounts of data. However, alongside natural tectonic earthquakes, seismic networks also record anthropogenic events such as quarry blasts or other induced events. Identifying and distinguishing these events from natural earthquakes requires experienced interpreters to ensure that seismological studies of natural phenomena are not compromised by anthropogenic events. Advanced artificial intelligence methods have already been deployed to tackle this problem. One of the applications includes Convolutional Neural Networks (CNN) to discriminate different kinds of events, such as natural earthquakes and quarry blasts. In this study, we investigate the effects of ensemble averaging and fine-tuning on seismic event discrimination accuracy to estimate the potential of these methods. We compare discrimination accuracy of two different CNN model architectures across three datasets. This was done with the best models from an ensemble of each model architecture, as well as with ensemble averaging and fine-tuning methods. Soft voting was used for the CNN ensemble predictions. For the transfer learning approach, the models were pretrained with data from two of the datasets (nontarget regions) and fine-tuned with data from the third one (target region). The results show that ensemble averaging and fine-tuning of CNN models leads to better generalization of the model predictions. For the region with the lowest numbers of one event type, the combination of ensemble averaging and fine-tuning led to an increase in discrimination accuracy of up to 4% at station level and up to 10% at event level. We also tested the impact of the amount of training data on the fine-tuning method, showing, that to create a global model, the selection of comprehensive training data is needed.