bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurses’ perception of medication administration errors and factors associated with their reporting in the neonatal intensive care unit
Authors: Henry Basil Josephine , Premakumar Chandini Menon , Mhd Ali Adliah , Mohd Tahir Nurul Ain , Seman Zamtira , Voo James Yau Hon , Mohamed Shah Noraida 
Published: December 2023

Abstract
Medication administration is a complex process, and nurses play a central role in this process. Errors during administration are associated with severe patient harm and significant economic burden. However, the prevalence of under-reporting makes it challenging when analysing the current landscape of medication administration error (MAE) and hinders the implementation of improvements to the existing system. The aim of this study is to describe the reasons for the occurrence of MAEs and the reasons behind the under-reporting of MAEs, to determine the estimated percentage of MAE reporting and to identify factors associated with them from the nurses’ perspective. This cross-sectional study was conducted using a validated self-administered questionnaire. The questionnaire contained 65 questions which were divided into three sections: (i) reasons for the occurrence of MAEs, which consisted of 29 items; (ii) reasons for not reporting MAEs, which consisted of 16 items; and (iii) percentage of MAEs actually reported, which consisted of 20 items. It was distributed to 143 nurses in the neonatal intensive care units of five public hospitals in Malaysia. Multivariable logistic regression was used to identify the factors associated with MAE reporting. The estimated percentage of MAE reporting was 30.6%. The most common reasons for MAEs were inadequate nursing staff (5.14 [SD 1.25]), followed by drugs which look alike (4.65 [SD 1.06]) and similar drug packaging (4.41 [SD 1.18]). The most common reasons for not reporting MAEs were that nursing administration focuses on the individual rather than looking at the systems as a potential cause of the error (4.56 [SD 1.32]) and that too much emphasis is placed on MAEs as a measure of the quality of nursing care (4.31 [SD 1.23]). Factors statistically significant with MAE reporting were administration response (adjusted odds ratio [AOR] = 6.90; 95% confidence interval (CI) = 2.01–23.67; P = 0.002), reporting effort (AOR = 3.67; 95% CI = 1.68–8.01; P = 0.001), and nurses with advanced diploma (AOR = 0.29; 95% CI = 0.13–0.65; P = 0.003). Our findings show that under-reporting of MAEs is still common and less than a third of the respondents reported MAEs. Therefore, to encourage error reporting, emphasis should be placed on the benefits of reporting, adopting a non-punitive approach, and creating a blame-free culture.
Distinctive physical properties of DNA shared by RNA polymerase II gene promoters and 5′-flanking regions of tRNA genes
Authors: Uemura Kohei , Ohyama Takashi 
Published: December 2023

Abstract
Numerous noncoding (nc)RNAs have been identified. Similar to the transcription of protein-coding (mRNA) genes, long noncoding (lnc)RNA genes and most of micro (mi)RNA genes are transcribed by RNA polymerase II (Pol II). In the transcription of mRNA genes, core promoters play an indispensable role; they support the assembly of the preinitiation complex (PIC). However, the structural and/or physical properties of the core promoters of lncRNA and miRNA genes remain largely unexplored, in contrast with those of mRNA genes. Using the core promoters of human genes, we analyzed the repertoire and population ratios of residing core promoter elements (CPEs) and calculated the following five DNA physical properties (DPPs): duplex DNA free energy, base stacking energy, protein-induced deformability, rigidity and stabilizing energy of Z-DNA. Here, we show that their CPE and DPP profiles are similar to those of mRNA gene promoters. Importantly, the core promoters of these three classes of genes have two highly distinctive sites in their DPP profiles around the TSS and position −27. Similar characteristics in DPPs are also found in the 5′-flanking regions of tRNA genes, indicating their common essential roles in transcription initiation over the kingdom of RNA polymerases.
Production and characterization of an Fv-clasp of rheumatoid factor, a low-affinity human autoantibody
Authors: Yamamoto Maruto , Funada Ryoma , Taki Ryota , Shiroishi Mitsunori 
Published: December 2023

Abstract
Rheumatoid factor (RF) is an autoantibody against IgG that affects autoimmune diseases and inhibits the effectiveness of pharmaceuticals and diagnostic agents. Although RFs derived from various germline genes have been identified, little is known about their molecular recognition mechanisms. In this study, the Fv-clasp format was used to prepare YES8c, an RF. We developed an Escherichia coli secretion expression system capable of producing milligram-scale of YES8c Fv-clasp per 1 L of culture. Although YES8c is an autoantibody with very low affinity, the produced Fv-clasp maintained specific binding to IgG. Interestingly, the molecules prepared by E. coli secretion had a higher affinity than those prepared by refolding. In the structure of the YES8c–Fc complex, the N-terminus of the light chain is close to Fc; therefore, it is suggested that the addition of the N-terminal methionine may cause collisions with Fc, resulting in reduced affinity. Our findings suggest that the Fv-clasp, which provides sufficient stability and a high bacterial yield, is a useful format for studying RFs with very low affinity. Furthermore, the Fv-clasp produced from a secretion expression system, which can properly process the N-terminus, would be suitable for analysis of RFs in which the N-terminus may be involved in interactions.
One Health Initiative: Delusional Parasitosis Needs Assessment, Tennessee 2022
Authors: Peña Sandra A , Springer Cary M , Trout Fryxell Rebecca , Phillips Lopez Eleanor , Vail Karen M 
Published: December 2023

AbstractDelusional parasitosis (DP) is a false, persistent belief that an individual is infested with organisms, especially arthropods, of a parasitic nature. It is a complex and challenging problem that impacts healthcare, the pest management industry, state-led agriculture and health agencies, Extension professionals, and academia because of time burdens and frustration associated with interactions. To address the handling of suspected DP cases, we assembled a University of Tennessee One Health Initiative Working Group with individuals representing diverse disciplines and professions. The Working Group developed and conducted an online needs assessment of pest management, Extension, and health professionals to (i) understand their interactions with suspected DP cases and (ii) determine the educational resources used and needed. Of the pest management professionals and Extension personnel, 72.7% (n = 112) of the respondents indicated they had encountered someone with suspected DP within the last year. Those responding to suspected DP cases spent significantly more time and interactions than what was required for general inquiries. Seventy-three percent of respondents received specimens of which more were human derived (54.4%) than nonhuman derived (41.5%), potentially putting these nonhealthcare professionals at risk of potential contagion. We confirmed a lack of available resources, including protocols, training materials, and resources for expert medical referrals. Additionally, the staff responsible for handling these cases were concerned for their safety. After identifying the most pressing needs, the One Health Working Group members collaborated to produce comprehensive resources to assist professionals in identifying DP cases more quickly and efficiently routing them to essential care.
Factor Overnight GARCH-Itô Models
Authors: Kim Donggyu , Oh Minseog , Song Xinyu , Wang Yazhen 
Published: December 2023

Abstract
This article introduces a unified factor overnight GARCH-Itô model for large volatility matrix estimation and prediction. To account for whole-day market dynamics, the proposed model has two different instantaneous factor volatility processes for the open-to-close and close-to-open periods, while each embeds the discrete-time multivariate GARCH model structure. To estimate latent factor volatility, we assume the low rank plus sparse structure and employ nonparametric estimation procedures. Then, based on the connection between the discrete-time model structure and the continuous-time diffusion process, we propose a weighted least squares estimation procedure with the non-parametric factor volatility estimator and establish its asymptotic theorems.
Theoretical modelling of the adsorption of neutral and charged sulphur-bearing species on to olivine nanoclusters
Authors: Perrero Jessica , Beitia-Antero Leire , Fuente Asunción , Ugliengo Piero , Rimola Albert 
Published: December 2023

ABSTRACT
Sulphur depletion in the interstellar medium (ISM) is a long-standing issue, as only 1 per cent of its cosmic abundance is detected in dense molecular clouds (MCs), while it does not appear to be depleted in other environments. In addition to gas phase species, MCs also contain interstellar dust grains, which are irregular, micron-sized, solid aggregates of carbonaceous materials, and/or silicates. Grains provide a surface where species can meet, accrete, and react. Although freeze-out of sulphur on to dust grains could explain its depletion, only OCS and, tentatively, SO2 were observed on their surfaces. Therefore, it is our aim to investigate the interaction between sulphur-containing species and the exposed mineral core of the grains at a stage prior to when sulphur depletion is observed. Here, the grain core is represented by olivine nanoclusters, one of the most abundant minerals in the ISM, with composition Mg4Si2O8 and Mg3FeSi2O8. We performed a series of quantum mechanical calculations to characterize the adsorption of nine S-bearing species, both neutral and charged, on to the nanoclusters. Our calculations reveal that the Fe–S interaction is preferred to Mg–S, causing sometimes the chemisorption of the adsorbate. These species are more strongly adsorbed on the bare dust grain silicate cores than on water ice mantles, and hence therefore likely sticking on the surface of grains forming part of the grain core. This demonstrates that the interaction of bare grains with sulphur species in cloud envelopes can determine the S-depletion observed in dense molecular clouds.
Galaxy clustering measurements out to redshift z ˜ 8 from Hubble Legacy Fields
Authors: Dalmasso Nicolò , Trenti Michele , Leethochawalit Nicha 
Published: December 2023

ABSTRACT
We present a novel approach for measuring the two-point correlation function of galaxies in narrow pencil beam surveys with varying depths. Our methodology is utilized to expand high-redshift galaxy clustering investigations up to z ∼ 8 by analysing a comprehensive sample consisting of Ng = 160 Lyman break galaxy candidates obtained through optical and near-infrared photometric data within the CANDELS GOODS data sets from the Hubble Space Telescope Legacy Fields. For bright sources with MUV &lt; −19.8, we determine a galaxy bias of b = 9.33 ± 4.90 at $\overline{z} = 7.7$ and a correlation length of r0 = 10.74 ± 7.06 $h^{-1}\, \mathrm{Mpc}$. We obtain similar results for the XDF, with a galaxy bias measurement of b = 8.26 ± 3.41 at the same redshift for a slightly fainter sample with a median luminosity of MUV = −18.4. By comparing with dark-matter halo bias and employing abundance matching, we deduce a characteristic halo mass of Mh ∼ 1011.5 M⊙ and a duty cycle close to unity. To validate our approach for variable-depth data sets, we replicate the analysis in a region with near-uniform depth using a standard two-point correlation function estimator, yielding consistent outcomes. Our study not only provides a valuable tool for future utilization in JWST data sets but also suggests that the clustering of early galaxies continues to increase with redshift beyond z ≳ 8, potentially contributing to the existence of protocluster structures observed in early JWST imaging and spectroscopic surveys at z ≳ 8.
Radial phase spirals in the Solar neighbourhood
Authors: Hunt Jason A S , Price-Whelan Adrian M , Johnston Kathryn V , McClure Rachel L , Filion Carrie , Cassese Ben , Horta Danny 
Published: December 2023

ABSTRACT
The second data release of ESA’s Gaia mission revealed numerous signatures of disequilibrium in the Milky Way’s disc. These signatures are seen in the planar kinematics of stars, which manifest as ridges and ripples in R–vϕ, and in vertical kinematics, where a prominent spiral is seen in the z–vz phase space. In this work, we show an equivalent ΔR–vR phase spiral forms following a perturbation to the disc. We demonstrate the behaviour of the ΔR–vR phase spirals in both a toy model and a high-resolution N-body simulation of a satellite interaction. We then confront these models with the data, where we find partial ΔR–vR phase spirals in the Solar neighbourhood using the most recent data from Gaia DR3. This structure indicates ongoing radial phase mixing in the Galactic disc, suggesting a history of recent perturbations, either through internal or external (e.g. satellite) processes. Future work modelling the z–vz and ΔR–vR phase spirals in tandem may help break degeneracy’s between possible origins of the perturbation.
Preoperative radiographs underdiagnose the severity of lateral femoral and medial trochlear cartilage damage in varus osteoarthritis knees
Authors: Maeda Takahiro , Kuriyama Shinichi , Ito Takayuki , Umatani Naoki , Nishitani Kohei , Nakamura Shinichiro , Matsuda Shuichi 
Published: December 2023

ABSTRACT

Objective
This study evaluated whether preoperative radiographs accurately predicted intra-articular cartilage damage in varus knees.

Methods
The study assessed 181 knees in 156 patients who underwent total knee arthroplasty. Cartilage damage was graded by two examiners with the International Cartilage Repair Society classification; one used knee radiographs and the other used intraoperative photographs. It was then determined if this radiographic cartilage assessment over- or underestimated the actual damage severity. Knee morphological characteristics affecting radiographic misestimation of damage severity were also identified.

Results
The concordance rate between radiographic and intraoperative assessments of the medial femoral condyle was high, at around 0.7. Large discrepancies were found for the lateral femoral condyle and medial trochlear groove. Radiographic assessment underestimated cartilage damage on the medial side of the lateral femoral condyle due to a large lateral tibiofemoral joint opening and severe varus alignment {both r = −0.43}. Medial trochlear damage was also underdiagnosed, in cases of residual medial tibiofemoral cartilage and shallow medial tibial slope {r = −0.25 and −0.21, respectively}.

Conclusions
Radiographic evaluation of knee osteoarthritis was moderately practical using International Cartilage Repair Society grades. Lateral femoral condyle and medial trochlear cartilage damage tended to be misestimated, but considering morphologic factors might improve the diagnostic rate.
Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A
Authors: Gu Xiang , Zhuang Ai , Yu Jie , Yang Ludi , Ge Shengfang , Ruan Jing , Jia Renbing , Fan Xianqun , Chai Peiwei 
Published: December 2023

Abstract
Albeit N1-Methyladenosine (m1A) RNA modification represents an important regulator of RNA metabolism, the role of m1A modification in carcinogenesis remains enigmatic. Herein, we found that histone lactylation enhances ALKBH3 expression and simultaneously attenuates the formation of tumor-suppressive promyelocytic leukemia protein (PML) condensates by removing the m1A methylation of SP100A, promoting the malignant transformation of cancers. First, ALKBH3 is specifically upregulated in high-risk ocular melanoma due to excessive histone lactylation levels, referring to m1A hypomethylation status. Moreover, the multiomics analysis subsequently identified that SP100A, a core component for PML bodies, serves as a downstream candidate target for ALKBH3. Therapeutically, the silencing of ALKBH3 exhibits efficient therapeutic efficacy in melanoma both in vitro and in vivo, which could be reversed by the depletion of SP100A. Mechanistically, we found that YTHDF1 is responsible for recognition of the m1A methylated SP100A transcript, which increases its RNA stability and translational efficacy. Conclusively, we initially demonstrated that m1A modification is necessary for tumor suppressor gene expression, expanding the current understandings of dynamic m1A function during tumor progression. In addition, our results indicate that lactylation-driven ALKBH3 is essential for the formation of PML nuclear condensates, which bridges our knowledge of m1A modification, metabolic reprogramming, and phase-separation events.
Energy and nutrient intake by people with and without sarcopenia diagnosed by the European Working Group on Sarcopenia in Older People: a systematic review and meta-analysis
Authors: Almeida Naiade Silveira , Rocha Raquel , de Souza Claudineia Almeida , Daltro Carla , de Farias Costa Priscila Ribas , de Oliveira Tatiane Melo , de Oliveira Leite Luana , Cotrim Helma P 
Published: December 2023

Abstract

Context
There is growing evidence that insufficient dietary intake is associated with sarcopenia.

Objective
In this systematic review and meta-analysis, the energy and nutrient intakes by people with and without sarcopenia were compared using only the European Working Group on Sarcopenia in Older People 2010 (EWGSOP1) and 2019 (EWGSOP2) consensus diagnostic criteria.

Data Sources
Only observational studies that compared energy and nutrient intake from food alone by individuals with and without sarcopenia were included. Studies were searched in the following databases: Embase, PubMed, Scopus, Web of Science, Lilacs, Ovid, and Scopus. The review followed the PRISMA checklist and submitted the protocol to PROSPERO.

Data Extraction
Data were extracted by 2 authors independently. The methodological quality of the studies was assessed using the Newcastle-Ottawa scale.

Data Analysis
A total of 8648 articles were identified and 12 were selected. Among individuals with sarcopenia, lower intakes of energy and some nutrients, mainly with antioxidant properties, were observed compared with those without sarcopenia. Meta-analyses showed that individuals with sarcopenia consume fewer calories/day than individuals without sarcopenia (n = 10 studies; standardized mean difference (SMD) −0.15; 95% confidence interval: −0.29, −0.01) diagnosed by EWGSOP1 and EWGSOP2. Individuals with sarcopenia consume less omega-3, folate, magnesium, phosphorus, selenium, zinc, and vitamins C, D, and E when compared with those without sarcopenia.

Conclusion
The results of the present study suggest that insufficient intake of energy and nutrients with antioxidant potential may be associated with sarcopenia.

Systematic Review Registration
PROSPERO registration no. CRD 42020195698.
The effect of oral dietary interventions on nutritional status and treatment tolerance in patients with hematologic neoplasms receiving chemotherapy: a systematic review
Authors: Dambrós Betina Fernanda , Kobus Rafaela Alexia , da Rosa Raquel , Pereira Luciana Jeremias , Hinnig Patrícia de Fragas , Di Pietro Patricia Faria , Kunradi Vieira Francilene Gracieli 
Published: December 2023

Abstract

Context
Adverse events from chemotherapy treatment affect food intake, nutritional status, and treatment tolerance in cancer patients. However, the effect of nutritional intervention in patients with hematologic neoplasms receiving chemotherapy remains unknown.

Objective
The aim of this systematic review was to evaluate the evidence on nutritional interventions on nutritional status, treatment tolerance, inflammatory markers, quality of life, and mortality in patients with hematologic neoplasms receiving chemotherapy.

Data Sources
The MEDLINE, LILACS, CINAHL, Web of Science, Embase, ICTRP, CENTRAL, and ClinicalTrials.gov databases were searched. Additional literature and the bibliographies of identified articles were also considered.

Data Extraction
Randomized controlled trials in individuals with hematologic neoplasms receiving chemotherapy along with nutritional counseling and oral nutritional supplementation, and intake of supplementary food products, alone or in combination, were assessed as criteria of interest. The data were extracted independently by 2 researchers. The risk of bias was assessed through the Cochrane risk-of-bias tool (RoB 2).

Data Analysis
Ten studies were included up to August 15, 2022 (updated in November of 2022). With regard to the outcomes, 4 studies assessed nutritional status and 2 studies showed a positive result of the intervention on some of the markers. Seven studies assessed certain markers of treatment tolerance and only 2 studies showed improvement in the outcome after the intervention.

Conclusion
The studies that found positive results are quite different from each other in terms of intervention, study time, and design. More randomized controlled trials are needed to test different dietary interventions using placebo and blinding, when possible, and with reduced sample variability in individuals with hematologic neoplasms receiving chemotherapy.

Systematic Review Registration
PROSPERO registration no. CRD42020196765.
Linear stability of a compressible flow in a channel
Authors: Deka M , Tomar G , Kumaran V 
Published: December 2023

Summary
Modal instabilities in a compressible flow through a channel at high Reynolds numbers are studied for three-dimensional (3D) perturbations. In addition to the Tollmien–Schlichting (TS) mode, there exist compressible modes in a channel flow that do not have a counterpart in the incompressible limit. The stability characteristics of these compressible modes, obtained through numerical calculations, are compared with boundary layer and Couette flows that have been previously studied. The dominant compressible instabilities in a channel flow are shown to be viscous in nature, in contrast to compressible boundary layer modes. For general compressible bounded-domain flows, a necessary condition for the existence of neutral modes in the inviscid limit is obtained, and this criterion is used to determine critical Mach numbers below which the compressible modes remain stable. This criterion also delineates a range of wave-angles which could go unstable at a specified Mach number. Asymptotic analysis is carried out for the lower and upper branches of the stability curve in the limit of high Reynolds number for both the T-S and the compressible modes. A common set of relations are identified for the scaling exponents, and the leading order eigenvalues for the unstable modes are obtained through an adjoint-based procedure. The asymptotic analysis shows that the stability boundaries for 3D perturbations at high Reynolds numbers can be calculated from the strain rate and the temperature of the base flow at the wall.