bluuebunny/crossref_metadata_2025_split huggingface dataset:
Purse string suture for hemostasis after removal of large-caliber femoral venous delivery sheaths in pediatric transcatheter intervention of atrial septal defect: a single center experience
Authors: Luo Gang , Ji zhixian , Zhang Bei , Ren Yueyi , Pan Silin 
Published: December 2023

Abstract

The objective of this study is to evaluate the efficacy and safety of purse-string suture compared with manual compressing for hemostasis in children with atrial septal defect (ASD) after large-caliber venous delivery sheath removal. We conducted a retrospective study of 271 children with ASD were treated with transcatheter closure of the large-calibe venous delivery sheath (≥ 8 Fr) at our center from January 2018 to January 2023. The control group (n = 127) underwent manual compression for femoral venous hemostasis after removal sheaths. The purse string suture (PSS) group (n = 144) underwent PSS technique. Contrast clinical data on hemostatic time, limb braking time, bed rest time, hospital stay and complications (rebleeding, hematoma formation, local blood ooze, skin ecchymosis and skin damage) between two groups of patients. Compared with the control group, the average hemostatic time (4.63 ± 1.95 vs. 19.69 ± 5.64) min, limb bending time (6.83 ± 2.25 vs. 13.45 ± 2.87) h and bed rest time (8.69 ± 1.43 vs. 22.93 ± 2.24) h were significantly shorter in the PSS group, compared to the control group (P < 0.001). The differences regarding hospital stay and complications between the two groups were statistically insignificant (P༞0.05). Conclusions: The PSS is a straightforward, effective, and secure procedure for attaining rapid hemostasis after removal of large-calibe venous delivery sheath (≥ 8 Fr) for transcatheter closure of ASD in children. The PSS enables pediatric patients to access earlier mobilization and physical activity, a shorter bed rest duration and relief of discomfort when compared to manual compression.
COVID-19 outbreak among employees of a German hospital – risk factor analysis based on a follow-up questionnaire and seroprevalence
Authors: Kosenkow Jennifer , Ankert Juliane , Baier Michael , Kesselmeier Miriam , Pletz Mathias W. 
Published: December 2023

Abstract
The Co-FriSero study (COVID-Friedrichroda seroprevalence study) describes a COVID-19 outbreak in a German hospital with 185 beds (Friedrichroda/Thuringia) and 404 employees at the beginning of the pandemics, which was followed up with a questionnaire and seroprevalence study of the entire hospital staff. Seroprevalence was assessed using two different immunoassays to detect IgG and a third different immunoassay in those with discordant results. Between March 30th 2020 and April 13th 2020, a COVID-19 outbreak occurred within the hospital staff. SARS-CoV-2 infection was confirmed in 25 of 229 employees screened by PCR and in 7 employees by serology only. Employee-reported compliance with wearing personal protective equipment (PPE) differed between those working in the high-risk area (80%) and those in the medium-risk area (72%). Statistical analysis of risk factors revealed an association between SARS-CoV-2 infection and the following potential sources of infection: direct patient contact, exposure to patients with high flow ventilation through unclosed room doors, direct contact with colleagues, lounge, and carpooling among staff. No direct link to infection was represented by contact with family and friends, or public transportation, visiting public events and using health care worker locker rooms. This study underscores that during the early stages of the pandemic, direct patient contact, particularly with ventilated patients through open doors, and inadequate hygiene measures increased the risk for health care workers. Additionally, the study suggests that once introduced, the pathogen can spread outside the hospital setting via staff interactions, emphasizing the need to consider previously overlooked transmission routes, such as carpooling, in future pandemic planning.
Do deep regional trade agreements facilitate regional production networks in Latin American and Caribbean countries?
Authors: Murakami Yoshimichi 
Published: December 2023

Abstract

Using a structural gravity model, this study analyzes the causal effects of the depth of regional trade agreements (RTAs) measured by the coverage and legal enforceability of WTO-plus and WTO-extra policy areas on the production networks trade in all 33 Latin American and Caribbean (LAC) countries from 1990 to 2016. The study constructs a unique dataset on the indexes of the depth, breadth, and core depth of all RTAs in force that include at least two LAC countries, based on a World Bank database on RTAs’ contents. Results indicate that both the depth and breadth of RTAs have positive effects on the intra-regional parts and components exports in the LAC region. However, the effects are substantially heterogeneous by the type of agreements and the characteristics of country-pairs. The depth of custom unions among Latin American countries, mainly the Southern Common Market (MERCOSUR), has positive effects, whereas the depth and breadth of plurilateral free trade agreements with developed countries outside the region (e.g., the United States or European countries) have negative effects. These findings are robust to the use of the mirror import data, the use of three-year interval data, and the inclusion of future values that control for reverse causality.
One is Not Enough: Multi-Agent Conversation Framework Enhances Rare Disease Diagnostic Capabilities of Large Language Models
Authors: Li Jian , Chen Xi , Liu Weizhi , Wang Li , Guo Yingman , You Mingke , Chen Gang , Li Kang 
Published: December 2023

Abstract
Importance
This study adopted multi-agent framework in large language models to enhance diagnosis in complex medical cases, particularly rare diseases, revealing limitation in current training and benchmarking of LLMs in healthcare.
Objective
This study aimed to develop MAC LLMs for medical diagnosis, and compare the knowledge base and diagnostic capabilities of GPT-3.5, GPT-4, and MAC in the context of rare diseases.
Design, Setting and Participants
This study examined 150 rare diseases using clinical case reports published after January 1, 2022, from the Medline database. Each case was curated, and both the initial and complete presentations were extracted to simulate the different stages of patient consultation. A MAC framework was developed. Disease knowledge base was tested using GPT-3.5, GPT-4, and the MAC. Each case was subjected to the three models to generate one most likely diagnosis, several possible diagnoses, and further diagnostic tests. The results were presented for panel discussions with physicians. Disease knowledge was evaluated. The accuracy and scoring of the one most likely diagnosis, several possible diagnoses, and further diagnostic tests were also evaluated.
Main Outcomes And Measures:
Scoring of disease knowledge. Accuracy and scoring of the one most likely diagnosis, several possible diagnoses and further diagnostic tests.
Results
In terms of disease-specific knowledge, GPT-3.5, GPT-4, and MAC scored above 4.5 on average for each aspect. In terms of diagnostic ability, MAC outperformed GPT-3.5 and GPT-4 in initial presentations, achieving higher accuracy in the most likely diagnoses (28%), possible diagnoses (47.3%), and further diagnostic tests (83.3%). GPT-3.5 and GPT-4 exhibited lower accuracy in these areas. In complete presentations, MAC continued to demonstrate higher accuracies in the most likely diagnosis (48.0%) and possible diagnoses (66.7%) compared to GPT-3.5 and GPT-4. Diagnostic capability scoring also indicated higher performance for MAC.
Conclusion And Relevance
Despite the comprehensive knowledge base of GPT-3.5 and GPT-4, a noticeable gap exists in their clinical application for diagnosing rare diseases, underscoring the limitations in the current training and benchmarking methods of LLMs within the healthcare sector. Compared with single-agent models, the MAC framework markedly improves the diagnostic ability of LLMs, enabling more in-depth analysis. Therefore, the MAC framework is a promising tool for the diagnosis of rare diseases in clinical settings and warrants further research to fully explore its potential.
Feasibility of physical function assessment in children with nephrotic syndrome- A preliminary cross-sectional study
Authors: R Lekha , V Hamsa , Alva Rajitha 
Published: December 2023

Abstract
Background
Nephrotic syndrome (NS) is one of the common paediatric renal diseases, primarily managed by steroid therapy. Steroid therapy is associated with significant complications, including reduction in the quality of life in these patients. However, there is lack of evidence addressing the physical function (PF) among children with NS. Therefore, this study aims to assess feasibility of PF evaluation in children with NS and to correlate with the steroid dosage.
Methods
A cross-sectional study included children aged 6 to 12 years diagnosed with NS receiving steroid therapy in the last 6 months. PF assessment included muscle strength (hand-grip strength - HGS), cardio-respiratory endurance (2 Minute Walk Test – 2MWT) and flexibility (Sit and Reach Test - SRT). Descriptive statistics and correlation with the steroid dosage (Mann-Whitney test) were performed using SPSS v.21.
Results
Study included 24 children (50% boys) with a mean age of 8.3years and BMI of (18.16 ± 3.63kg/m²). All three PF components i.e.,2MWT (155.7 ± 38.6m), HGS -boys(9.19 ± 4.08kgs),HGS– girls(8.54 ± 2.32kgs) and SRT(-7.36 ± 4.9cm)exhibited significant reduction in comparison with normative data (p < 0.05, CI 95%). There was no significant correlation between the cumulative steroid dose and PF in the last 6 months.
Conclusion
Children with NS have significant compromise in their physical function compared to normative data. The findings of the study support the need for incorporating routine physical function assessment into the routine standard care protocols in these children.
Effects of Cybersickness Mitigation Methods on Behavior: A Comparative Study Based on the Skill–Rule–Knowledge Model
Authors: Qi Shuaixin , Menozzi Marino 
Published: December 2023

Abstract

Cybersickness (CS) is a pressing issue in virtual reality (VR) systems. While various mitigation methods (MMs) have been developed to counteract CS, their effects on human behavior remain largely unexplored, raising concerns about their potential applications. Using Jens Rasmussen's skill--rule--knowledge (SRK) model as a framework, our study investigated the effects of two widely adopted MMs---dynamic field of view and dynamic blurring---in VR. We compared these methods to a baseline condition where no MM was applied. We designed three VR tasks that align with the behavioral levels of the SRK model. In a within-subject study (N = 22), participants completed each task using these MMs. We measured task performance, CS symptoms, and locomotion control. Additionally, qualitative feedback was collected. Our results revealed that neither MM significantly alleviated CS across different VR scenarios. Furthermore, while some participants found MMs helpful, a larger portion reported visual hindrances, and a significant performance drop was measured in the skill-based task. More critically, participants indicated behavioral adaptations in response to the MMs, including changes in locomotion strategies and viewing behavior. Potential causes and implications were discussed. In conclusion, MMs offer promise, but their application necessitates a nuanced understanding of their impacts. We recommend a context-sensitive approach when designing and integrating MMs, prioritizing both maximizing CS mitigation and minimizing interference with the natural behaviors of users.
Getting up for brain health: association of sedentary behavior breaks with cognition and mental health in children
Authors: Fochesatto Camila Felin , Brand Caroline , Cristi-Montero Carlos , Costa Bruno Gonçalves Galdino , Dias Arieli Fernandes , Gaya Adroaldo Cezar Araujo , Gaya Anelise Reis 
Published: December 2023

Abstract
Aim
to verify the role of body mass index (BMI), cardiorespiratory fitness (CRF), and moderate to vigorous physical activity (MVPA) in the relationship between the break in sedentary time with cognitive and mental health in children.
Methods
Cross-sectional study with 129 children (62 boys), aged between six and 11 years (mean 8.73 ± 1.53) from a public school in southern Brazil. For the assessment of fluid intelligence, psychologists applied Raven's Colored Progressive Matrices test. Mental health was measured using the Strengths and Difficulties Questionnaire. Sedentary breaks were measured using accelerometers and CRF was determined by the 6-minute walk test. Generalized linear regression analyses were used to verify associations of sedentary breaks with fluid intelligence and mental health, according to children's BMI, CRF, and MVPA. All models were adjusted for sex, age, somatic maturation, and total time of accelerometer use.
Results
Our results indicated that sedentary breaks were associated with fluid intelligence in overweight/obese (β = 0.108; p = 0.021) and physically inactive children (β = 0.083; p = 0.010). Regarding mental health, no association was identified with sedentary breaks.
Conclusion
Sedentary breaks should be encouraged for the benefits of fluid intelligence, especially in children who do not meet physical activity recommendations and present overweight.
Comparison principle for Walsh's spider HJB equations with non linear local-time Kirchhoff's boundary transmission
Authors: Ohavi Isaac 
Published: December 2023

Abstract
The main purpose of this work is to obtain a comparison principle for viscosity solutions of a system of elliptic Walsh's spider Hamilton-Jacobi-Bellman equations, possessing a new boundary condition called non linear local-time Kirchhoff's transmission. The main idea is to build test functions at the neighborhood of the vertex solutions of ODE, with well-designed coefficients. The key point is to impose a 'local-time' derivative at the vertex absorbing the error term induced by - what we decide to call here - the Kirchhoff's speed of the Hamiltonians.
Mathematics Subject Classification (2010). 32W05, 35B05, 35J60, 35J65,
35R05, 49L25, 49N70, 60G55, 60J55, 60J50, 70H20
YOSEG Enhancing Instance Segmentation of Medical Small Targets
Authors: Xia Yifan , Zhu Dongqin , Mou Zhenao , Miao Cunke , Yuan Yaping , Yang Yunjun , Wang Ouchen , Pan Zhifang , Lin Yezhi 
Published: December 2023

Abstract

Image segmentation stands as a pivotal pillar in the vast realm of computer vision. Nonetheless, formidable challenges endure, particularly when confronted with tasks necessitating precision in delineating diminutive objects, as evidenced in the context of medical imaging for minute targets. Existing algorithms primarily cater to larger or medium-sized objects with specific dimensions or proportions. The persistent conundrum arises from the trifecta of minuscule target dimensions, feeble distinguishing features, and resultant subpar segmentation performance for diminutive objects. In response to these hurdles, our study introduces a pioneering solution christened You only look one segment network (YOSEG), adeptly crafted to tackle these issues head-on. Our comprehensive investigations involve two datasets: a proprietary collection comprising CT intracranial aneurysm data from multiple medical centers and the publicly available CBIS-DDSM dataset, which stands for Curated Breast Imaging Subset of DDSM and contains breast mass data. The outcomes of our approach substantiate remarkable strides in the precision of small object segmentation, marking a significant advancement in this critical field.
Exploring family communication preferences in hereditary breast and ovarian cancer and Lynch syndrome: A national Canadian survey
Authors: Burke Kimberly Amanda , Dawson Lesa , Hodgkinson Kathleen , Wilson Brenda J. , Etchegary Holly 
Published: December 2023

Abstract

Background:
Individuals affected with cancer predisposition syndromes such as BRCA1, BRCA2 or Lynch syndrome are at an elevated risk of multiple cancers. Identifying high-risk individuals is important if they are to access risk-reducing strategies. Interventions such as risk-reducing salpingo-oophorecomty in BRCA carriers or regular colonoscopy for carriers of Lynch syndrome are highly effective and reduce mortality. Despite clear evidence that the identification of at-risk relatives has value, the uptake of genetic testing remains at approximately 50%. It is important to understand better and explore options to improve hereditary cancer risk communication within affected families to ensure the uptake of genetic counselling and testing by those who wish it.
Method:
A national online survey of both Canadian probands (the first member in a family to have genetic testing) and at-risk relatives. Respondents were individuals affected with hereditary breast and ovarian cancer and Lynch syndrome. Survey items explored experiences with hereditary cancer risk communication, communication challenges, preferences and supports required.
Results:
Responses indicated a high level of acceptance for proband involvement in family communication, but also for support by providers in the process (67% among the probands given a family letter and 55–57% among those who were not given a family letter). Respondents without a history of cancer were more likely to desire a health care professional’s help with family communication compared to those with a history of cancer. Preferences for family member outreach also varied by education level, annual income, marital status and geographic location. Similarities were noted between the probands and relatives on communication outreach preferences.
Conclusion:
While the family-mediated approach to communication remains the standard of care in many places, it may not meet the needs of most individuals affected with hereditary cancer syndromes. Alternative options that retain the probands’ involvement in family communication but add support from a health care provider should be explored.
Need-Based Guidance and Counseling Services for Tertiary Students: The Antecedents and the Outcomes
Authors: Sedofia John , Nutsugah Francis Fonyee 
Published: December 2023

Abstract

The continuous decline in demand for guidance and counselling (G&C) in institutions of higher learning (IHLs) is blamed on the design of G&C not based on the needs of tertiary students, resulting in unsatisfactory G&C services provision. Based on psychological need theory, the study proposed a need-based guidance and counselling (NBGC) and explored its antecedents and examined its impacts on the expectations of tertiary students. The study relied on SmartPLS 3.8 to analyse data collected from 401 tertiary students drawn from 6 IHLs. The findings revealed that except academic needs, personal and social needs are the major determinants of NBGC. This study therefore, highlights the importance of NBGC and contributes to our understanding that NBGC can be used to improve students’ academic performance, desirable attitudes, self-discovery and self-confidence, interpersonal relationships, and their time and financial management skills.
Biological control of ultra-skeleton mineralization in coral
Authors: He Miaohong , Deng Wenfeng , Chen Xuefei , Zhang Yanqiang , Wei Gangjian 
Published: December 2023

Abstract
Understanding the mineralization of coral is significant for the formation of coral reefs and paleoclimatic reconstructions. However, the fundamental mechanisms involved in biomineralization are poorly understood. A combination of Raman spectral and cross-polarized reflected light microscopy imaging was used to examine the three-dimensional spatial distribution of the skeletal ultrastructures and their associated mineral, organic, and water chemistry in coral, which enable insight into the spatial growth features of the ultrastructures and possible formation processes. A possible mechanism is proposed that controls the formation of skeletal ultrastructures, which likely involves compartmentalized calcifying cells and their related cellular activities. This could clarify the association between coral skeletal mineralization and biology, and it may be beneficial to better protection and application of coral reefs.
Retracted: Visual design of water-based landscape environment based on the sustainable utilization of water resources
Authors: Hu Bin , Wang Yuxin , Liu Yuanxu , Zheng Lihong 
Published: December 2023

ABSTRACT
Water Supply issues a formal retraction in relation to the above article by Bin Hu, Yuxin Wang, Yuanxu Liu, and Lihong Zheng. The publisher issues this retraction due to concerns regarding potential citation manipulation due to inappropriate references. The journal did not receive a satisfactory response to address these concerns, and as a result, the Editors-in-Chief no longer have confidence in the integrity of the article. The authors acknowledged these concerns and supported the decision to retract the article.
Simultaneous Study of Analysis of Anti-inflammatory Potential of Dryopteris ramosa
(C. Hope) C. Chr. using GC-Mass and Computational Modeling on the
Xylene-induced Ear Oedema in Mouse Model
Authors: Said Khalil , Hamayun Muhammad , Rauf Mamoona , Khan Sumera Afzal , Arif Muhammad , Alrefaei Abdulwahed Fahad , Almutairi Mikhlid H. , Ali Sajid 
Published: December 2023

Introduction:
In the present study, we aimed to investigate the extraction and identification of the
potential phytochemicals from the Methanolic Extract of Dryopteris ramosa (MEDR) using GC-MS profiling
for validating the traditional uses of MEDR its efficacy in inflammations by using in-vitro, in-vivo and
in silico approaches in anti-inflammatory models

Method:
GC-MS analysis confirmed the presence of a total of 59 phytochemical compounds. The human red
blood cells (HRBC) membrane stabilization assay and heat-induced hemolysis method were used as in-vitro
anti-inflammatory activity of the extract. The in-vivo analysis was carried out through the Xylene-induced
mice ear oedema method. It was found that MEDR at a concentration of 20 μg, 30 μg, and 40 μg showed
35.45%, 36.01%, and 36.33% protection to HRBC in a hypotonic solution, respectively. At the same time,
standard Diclofenac at 30 μg showed 45.31% protection of HRBC in a hypotonic solution.

Result:
The extract showed inhibition of 25.32%, 26.53%, and 33.31% cell membrane lysis at heating at 20
μg, 30 μg, and 40 μg, respectively. In comparison, standard Diclofenac at 30 μg showed 50.49% inhibition of
denaturation to heat. Methanolic extract of the plant exhibited momentous inhibition in xylene-induced ear
oedema in mice treated with 30 μg extract were 47.2%, 63.4%, and 78.8%, while inhibition in mice ear oedema
treated with 60 μg extract was 34.7%, 43.05%, 63.21% and reduction in ear thickness of standard drug
were 57.3%, 59.54%, 60.42% recorded at the duration of 1, 4 and 24 hours of inflammation. Molecular docking
and simulations were performed to validate the anti-inflammatory role of the phytochemicals that revealed
five potential phytochemicals i.e. Stigmasterol,22,23dihydro, Heptadecane,8methyl, Pimaricacid, Germacrene
and 1,3Cyclohexadiene,_5(1,5dimethyl4hexenyl)-2methyl which revealed potential or significant inhibitory
effects on cyclooxygenase-2 (COX-2), tumour necrosis factor (TNF-α), and interleukin (IL-6) in the docking
analysis.

Conclusion:
The outcome of the study signifies that MEDR can offer a new prospect in the discovery of a
harmonizing and alternative therapy for inflammatory disease conditions.