bluuebunny/crossref_metadata_2025_split huggingface dataset:
The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken
Authors: Guabiraba Rodrigo , Saint-Martin Vincent , Guillory Vanaique , Chollot Melanie , Fleurot Isabelle , Kut Emmanuel , Roesch Ferdinand , Caballero Ignacio , Helloin Emmanuelle , Chambellon Emilie , Ferguson Brian , Velge Philippe , Kempf Florent , Trapp Sascha 
Published: December 2023

Abstract

The gut microbiota exerts profound influence on poultry immunity and metabolism through mechanisms that yet need to be elucidated. Here we used conventional and germ-free chickens to explore the influence of the gut microbiota on transcriptomic and metabolic signatures along the gut-lung axis in poultry. Our results demonstrated a differential regulation of certain metabolites and genes associated with innate immunity and metabolism in peripheral tissues of germ-free birds. Furthermore, we evidenced the gut microbiota's capacity to regulate mucosal immunity in the chicken lung during avian influenza virus infection. Finally, by fine-analysing the antiviral pathways triggered by the short-chain fatty acid (SCFA) butyrate in chicken respiratory epithelial cells, we found that it regulates interferon-stimulated genes (ISGs), notably OASL, via the transcription factor Sp1. These findings emphasize the pivotal role of the gut microbiota and its metabolites in shaping homeostasis and immunity in poultry, offering crucial insights into the mechanisms governing the gut-lung axis dialogue in birds.
Court of High Commission, Oath Ex Offcio and the Privilege Against Self-Incrimination in English Debates at the Turn of the XVI – XVII Centuries
Authors: Кондратьев С.В. 
Published: December 2023

Статья повествует о политической дискуссии о полномочиях Суда Высокой комиссии, используемых ею инквизиционных процедурах, присяге ex officio между юристом общего права Джеймсом Морисом и юристом цивильного права Ричардом Косином в Англии в начале 1590-х гг., в ходе которых затрагивались сферы общего и цивильного права, пределы королевской прерогативы, Великая хартия вольностей, права подданных, включая право не обвинять самого себя.
The article describes a political debate between common lawyer James Morice and civil Lawyer Richard Cosin on the powers of the Court of High Commission, its inquisitorial procedures, and the oath ex officio in England in the early 1590s, during which the areas of common and civil law, the limits of the royal prerogative, the Magna Carta, the liberties of subjects, including the privilege against self-incrimination were touched upon.
Seasonal distribution, source apportionment and risk assessment of polycyclic aromatic hydrocarbons in groundwaters in Owo, Southwestern Nigeria
Authors: Ore Odunayo T. , Bayode Ajibola A. , Badamasi Hamza , Olusola Johnson Adedeji , Durodola Solomon S. , Akeremale Olaniran K. , Adesina Morenike O. 
Published: December 2023

Abstract

The study focused on evaluating the seasonal distribution, source apportionment, and probabilistic risk assessment of polycyclic aromatic hydrocarbons (PAHs) in groundwater. Groundwater samples were obtained from Owo, southwestern Nigeria and subjected to liquid–liquid extraction and quantified using gas chromatography–mass spectrometry. Total PAH concentrations varied from about 180 to 23,600 ng/L during the dry season. The wet season, on the other hand, exhibited a wider range, from about 1,550 to 150,000 ng/L. Seasonal variations were also found in PAH types and concentrations, with relatively higher concentrations recorded during the wet season. Diagnostic ratios and positive matrix factorization indicated that coal/biomass combustion and traffic-related vehicular emissions were the prevalent sources of PAHs in groundwater. Health risk assessment indicated potential carcinogenic risks (incremental lifetime cancer risk (ILCR) &gt; 1E − 04), while ecological assessment suggested medium (RQNC &lt; 800 and RQMPC ≥ 1) and high ecological risks (RQNC ≥ 800 and RQMPC ≥ 1). The study reflected the need for effective mitigation strategies.
A Comprehensive Review on Targeted Cancer Therapy: New Face of
Treatment Approach
Authors: Karati Dipanjan , Kumar Dileep 
Published: December 2023

Abstract:
Cancer is one of life's most difficult difficulties and a severe health risk everywhere. Except for haematological
malignancies, it is characterized by unchecked cell growth and a lack of cell death, which results
in an aberrant tissue mass or tumour. Vascularization promotes tumor growth, which eventually aids metastasis
and migration to other parts of the body, ultimately resulting in death. The genetic material of the cells is
harmed or mutated by environmental or inherited influences, which results in cancer. Presently, anti-neoplastic
medications (chemotherapy, hormone, and biological therapies) are the treatment of choice for metastatic cancers,
whilst surgery and radiotherapy are the mainstays for local and non-metastatic tumors. Regrettably, chemotherapy
disturbs healthy cells with rapid proliferation, such as those in the gastrointestinal tract and hair follicles,
leading to the typical side effects of chemotherapy. Finding new, efficient, targeted therapies based on
modifications in the molecular biology of tumor cells is essential because current chemotherapeutic medications
are harmful and can cause the development of multidrug resistance. These new targeted therapies, which
are gaining popularity as demonstrated by the FDA-approved targeted cancer drugs in recent years, enter
molecules directly into tumor cells, diminishing the adverse reactions. A form of cancer treatment known as
targeted therapy goes after the proteins that regulate how cancer cells proliferate, divide, and disseminate.
Most patients with specific cancers, such as chronic myelogenous leukemia (commonly known as CML), will
have a target for a particular medicine, allowing them to be treated with that drug. Nonetheless, the tumor
must typically be examined to determine whether it includes drug targets.
Tumor Suppressive Role of MicroRNAs in Triple Negative Breast Cancer
Authors: Balkrishna Acharya , Mittal Rashmi , Arya Vedpriya 
Published: December 2023

Abstract:
Triple-negative breast cancers are highly aggressive, a heterogeneous form of breast cancer with a
high re-occurrence rate that further lacks an efficient treatment strategy and prognostic marker. The tumor microenvironment
of the disease comprises cancer-associated fibroblasts, cancer stem cells, immunological
molecules, epithelial-mesenchymal transition, and a metastatic microenvironment that contributes to disease
progression and metastasis to distant sites. Emerging evidence indicated that miRNA clusters would be of clinical
utility as they exert an oncogenic or tumor suppressor role in TNBC. The present review article aims to
highlight the therapeutic significance of miRNA in targeting the above-mentioned signaling cascades and modulating
the intracellular crosstalk in the tumor microenvironment of TNBC. Prognostic implications of miRNAs
to depict disease-free survival, distant metastasis-free survival, relapse-free survival, and overall survival
outcome were also unveiled.
The Recent Report on Schiff Bases and their Complexes as DNA Binders
Authors: Mansi  , Bhutani Charu , Khanna Pankaj , Jain Manisha , Talwar Sangeeta , Yadav Shilpa , Khanna Leena 
Published: December 2023

Abstract:
Schiff bases are dynamic organic compounds of bioactive importance, acting as
flexible ligands and can form complexes with metals. Schiff bases along with their metal
complexes have shown a large affinity towards DNA, which is one of the main targets of
chemotherapeutics. DNA can join hands with these motifs in multiple ways, like covalent
(crosslinking adducts) and non-covalent (intercalative or groove binding via electrostatic)
interactions. Besides, the binding ability and types vary with the metals involved in Schiff
base metal complexes. Thus, this review aims to describe significant recent reports of Schiff
bases and their metal complexes capable of binding with DNA to evaluate the superlative
DNA binders, type of association, and best metal-Schiff base combinations. Among the experimental
techniques employed in revealing these interactions, noteworthy UV absorption
and fluorescence spectroscopy studies have been discussed for the assessment of various types of bindings as
intercalation or groove type.
Anti-inflammatory and Antimicrobial Potential of 1, 3, 4-oxadiazoles and its
Derivatives: A Review
Authors: Chaudhary Tarun , Upadhyay Prabhat Kumar , Kataria Ritu 
Published: December 2023

Abstract:
1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial
property. Their precise mechanism of action is not known but it is postulated that they act
by inhibiting the biosynthesis of certain prostaglandins. 1, 3, 4-oxadiazoles are a class of heterocyclic
compounds with wide variety of biological and pharmacological activities. They have been
reported to possess analgesic, antimicrobial, antipyretic and anti-inflammatory properties. These
compounds are also active against a number of other inflammatory conditions such as arthritis,
gout etc. A wide variety of these compounds have been synthesized and some of them are under
clinical trials. In this review article, anti-inflammatory and antimicrobial activity of the 1, 3, 4-
oxadiazole shall be discussed.
Recent Advancements in the Synthesis of α-fluoroalkylated Azine-derived
Heterocycles through Direct Fluorination
Authors: Shavrina Oksana M. , Rassukana Yuliya V. , Onysko Petro P. 
Published: December 2023

Abstract:
The review highlights recent advancements in the synthesis of α-fluoro and α,α-difluoroalkylated azines, focusing on two main approaches. The first approach involves nu-cleophilic deoxofluorination, wherein α-hydroxy- or α-oxoalkylated azines are treated with diethylaminosulfur trifluoride or other S-F reagents to introduce fluorine atoms. The second approach employs direct electrophilic benzylic fluorination, whereby alkylazines undergo fluorination using N-F reagents. Both methods provide flexibility in designing and synthesiz-ing fluoroalkylated heterocycles.
Right Ventricle and Autoimmune Diseases
Authors: Valdés Corona Luis Francisco , Rodríguez Reyna Tatiana Sofía 
Published: December 2023

Abstract:
Autoimmune diseases can express pathologies in specific organs (e.g. thyroid, pancreas,
skin) or generate systemic pathologies (generalized lupus erythematosus, rheumatoid arthritis,
systemic sclerosis), the latter usually present systemic inflammatory phenomena.

:
Some studies have reported alterations in right ventricular contractility in patients with rheumatoid
arthritis, systemic lupus erythematosus, systemic sclerosis, and juvenile idiopathic arthritis,
which may contribute to the known outcome of increased cardiovascular risk. However, there is
not much information available on the causes that generate these alterations, the most likely being
small vessel damage and fibrosis due to subclinical inflammation.1-5 In this sense, the disease in
which the alterations of the right ventricle have been more studied is systemic sclerosis, specifically
at the changes induced due to pulmonary arterial hypertension, this being one of the main causes
of death in this group of patients after the significant decrease in mortality associated with the
sclerodermic renal crisis with the treatment of angiotensin-converting enzyme inhibitors.

:
In this review, we will focus on explaining the structural and functional changes that occur in the
right ventricle of patients with systemic sclerosis, from early alterations to late complications. In
this context, it is necessary to distinguish between right heart alterations that occur in patients with
systemic sclerosis and pulmonary arterial hypertension and those that occur without pulmonary arterial
hypertension and that can be attributed to other causes such as microvascular damage or myocardial
fibrosis.
COVID-19 Vaccines and the Menstrual Cycle: A Cross-Sectional Study
Authors: Al-Husban Naser , Al-Najjar Sondos , Alkubaisi Fatima Abdulsattar , M. Alzibdeh Abdulla , Yasin Kenan A.S , Alhusban Alhareth Eid 
Published: December 2023

Objective:
This study aimed to explore the impact of various COVID-19 vaccines on
the menstrual cycle of Jordanian women.

Materials and Methods:
We conducted a retrospective analysis of tracked menstrual changes using
an anonymous questionnaire written in the local language. We received 732 responses, and after
exclusions, 617 responses were analyzed. The questionnaire covered six sectors: demographics,
medical history, COVID-19 infection and vaccination status, obstetric and gynecological history,
menstrual cycle history, and specific questions about cycle length, flow, and any symptoms before
and after each vaccine shot. Participants included Jordanian females who had received any
type of COVID-19 vaccine.

Results:
Among the participants analyzed, two-thirds were between the ages of 20-35, and the majority
had a normal BMI (59.6%). Most participants were single, nulliparous, and had never used
contraception methods (79.3%, 82.0%, and 93.8%, respectively). Only a small percentage had
other risk factors influencing menstrual cycle changes, such as surgical procedures (10.5%) and
specific medications (8.10%). Baseline menstrual information was recorded. Forty percent of participants
experienced changes in menstrual duration, and approximately one-fifth reported heavier
and more severe premenstrual syndrome (PMS) symptoms. Body mass index (BMI) was directly
correlated with bleeding intensity after vaccination. Parity was weakly directly proportional to
bleeding intensity after vaccination. However, BMI and parity did not significantly correlate with
menstrual duration, menstrual cycle length, PMS symptoms, or cramps after vaccination.

Conclusion:
In a population of young, non-sexually active women with a normal BMI, most participants
did not experience significant changes in their menstrual cycles after receiving the
COVID-19 vaccine. Only one-fifth of participants reported shorter duration, heavier bleeding,
more frequent, more painful, and more severe PMS symptoms post-vaccination.
Menstrual Cup Awareness and Future Usage Possibilities of Consumers:
A Cross-sectional Study
Authors: Jain Tanushree , Katyal Tanya , Bharatam Sri Shivani Thatavarti , Kaushik Manthan , Ali Mohammad Daud , Patel Munfis , Zakir Foziyah , Khan Mohammed Zaafar , Mirza Mohd. Aamir , Iqbal Zeenat 
Published: December 2023

Background:
The World Health Organization (WHO) recommends that menstrual
health be recognized, defined, and addressed as a health and human rights issue rather than hygiene.
The UN has acknowledged menstrual health as a worldwide public health and human rights
concern. Poor menstrual health, inadequate sanitation facilities and inadequate education are defining
characteristics of period poverty.

Objective:
To assess and compare among different age groups of respondents regarding knowledge
and awareness regarding menstrual cup and their future possibilities for usage among women
of Delhi, India.

Methods:
A cross-sectional survey-based study was conducted between 1st April and 30th May
2022 among the females of Delhi NCR region, India.

Results:
A total of 339 females participated in our study, which included 250 (73.7%) above the
age of 20 years, whereas 89 (26.3%) were below that age. Most of the respondents were aware of
menstrual health products such as menstrual pads -241 (96.40) above 20 years, 83 (93.26) below
20 years with [CI-1.03 (0.73, 1.46) p-value = 0.85], cotton pads-158 (63.20%), 50 (56.18%),
[CI-1.12 (0.75, 1.67) p-value = 0.56], tampons-190 (76.00), 61 (68.54), CI- 1.10 (0.76, 1.61) pvalue
= 0.59, and menstrual disc-34 (13.60%), 18 (20.22%), CI-0.67 (0.36, 1.25) p-value = 0.21.
Among respondents above 20 years of age, 83.60% of respondents were aware of menstrual cups.
When asked about the biodegradability of the menstrual health product, 158 (63.2%) respondents
aged above 20 years and 54 (60.67%) respondents aged less than 20 years negated it [CI-1.04
(0.70, 1.54), p-value = 0.83].

Conclusion:
Our research can help organization policymakers understand that a menstrual cup is
an effective alternative to disposable sanitary products.
Biological Potential of a Bibenzyl Compound ‘Gigantol’ for the Treatment
of Human Disorders: Pharmacological Activities and Analytical Aspects of
an Active Phytochemical Isolated from Orchid
Authors: Patel Kanika , Singh Gireesh Kumar , Husain Gulam Mohammed , Prasad Satyendra K. , Patel Dinesh Kumar 
Published: December 2023

Background:
Dendrobium chrysotoxum Lindl. is an important medicinal plant of the genus
Dendrobium from the Orchidaceae family. Gigantol is one of the key bioactive phytochemicals found
in Dendrobium plants. Gigantol is reported to have diverse pharmacological activities

Aims:
This narrative review explores the analytical aspects along with pharmacological activities of
gigantol as reported in different scientific publications.

Methods:
To find appropriate information related to Dendrobium plants and gigantol, extensive data
extraction was done using ScienceDirect, Google, PubMed, and Scopus databases, and diverse facts
were collected, arranged and analyzed to know the therapeutic potential of gigantol. Analytical aspects
of gigantol were also discussed in the present work.

Results:
Gigantol has a wide distribution in the Dendrobium officinale, Dendrobium chrysanthum,
Dendrobium crystallinum, Dendrobium aphyllum, and Dendrobium devonianum. Available data indicates
diverse pharmacological activities of gigantol. Preclinical studies have shown its effectiveness
in the treatment of cataractogenesis, liver injury, leishmaniasis, nephrotoxicity, spasm, and skin disorders.
Gigantol has been found to control hepatocellular cancer, lung cancer, breast cancer, bladder
cancer, and cervical cancer. The neuroprotective, antinociceptive, anti-inflammatory, antioxidant,
vasorelaxant, immune modulatory effect, antimalarial, and anti-herpetic properties of gigantol have
also been observed. Applications of different analytical techniques for the isolation and characterization
of gigantol were also discussed in detail.

Conclusion:
Gigantol has significant and diverse pharmacological activities that must be explored in
clinical setup to develop therapeutic leads for different diseases and health conditions.
Anticancer Potential of a Synthetic Quinoline, 9IV-c, by Inducing Apoptosis in A549
Cell and In vivo BALB/c Mice Models
Authors: Mirzaei Salimeh , Eisvand Farhad , Nejabat Mojgan , Ghodsi Razieh , Hadizadeh Farzin 
Published: December 2023

Background:
In a previous work from the author of this study, the compound of 9IV-c, ((E)-2-(3,4-
dimethoxystyryl)-6,7,8-trimethoxy-N-(3,4,5-trimethoxyphenyl)quinoline-4-amine) was synthesized, and the
effects of potent activity on the multiple human tumor cell lines were evaluated considering the spindle formation
together with the microtubule network.

Methods:
Accordingly, cytotoxic activity, apoptotic effects, and the therapeutic efficiency of compound 9IV-c on
A549 and C26 cell lines were investigated in this study.

Results:
The compound 9IV-c demonstrated high cytotoxicity against A549 and C26 cell lines with IC50 = 1.66
and 1.21 μM, respectively. The flow cytometric analysis of the A549 cancer cell line treated with compounds
9IV-c showed that these compounds induced cell cycle arrest at the G2/M phase and apoptosis. Western blotting
analysis displayed that compound 9IV-c also elevated the Bax/Bcl-2 ratio and increased the activation of caspase-
9 and -3 but not caspase -8.

Conclusion:
These data presented that the intrinsic pathway was responsible for 9IV-c -induced cell apoptosis. In
vivo studies demonstrated that treatment with the compound of 9IV-c at 10 mg/kg dose led to a decrease in tumor
growth compared to the control group. It was found that there was not any apparent body weight loss in the period
of treatment. Also, in the vital organs of the BALB/c mice, observable pathologic changes were not detected.
Overview of the New Bioactive Heterocycles as Targeting Topoisomerase Inhibitors
Useful Against Colon Cancer
Authors: Santos Mirelly Barbosa , de Azevedo Teotônio Cavalcanti Misael , de Medeiros e Silva Yvnni Maria Sales , dos Santos Nascimento Igor José , de Moura Ricardo Olimpio 
Published: December 2023

Abstract:
Colorectal cancer (CRC) is the third most common cancer globally, with high mortality. Metastatic
CRC is incurable in most cases, and multiple drug therapy can increase patients' life expectancy by 2 to 3 years.
Efforts are being made to understand the relationship between topoisomerase enzymes and colorectal cancer.
Some studies have shown that higher expression of these enzymes is correlated to a poor prognosis for this type
of cancer. One of the primary drugs used in the treatment of CRC is Irinotecan, which can be used in monotherapy
or, more commonly, in therapeutic schemes such as FOLFIRI (Fluorouracil, Leucovorin, and Irinotecan) and
CAPIRI (Capecitabine and Irinotecan). Like Camptothecin, Irinotecan and other compounds have a mechanism
of action based on the formation of a ternary complex with topoisomerase I and DNA providing damage to it,
therefore leading to cell death. Thus, this review focused on the principal works published in the last ten years
that demonstrate a correlation between the inhibition of different isoforms of topoisomerase and in vitro cytotoxic
activity against CRC by natural products, semisynthetic and synthetic compounds of pyridine, quinoline, acridine,
imidazoles, indoles, and metal complexes. The results revealed that natural compounds, semisynthetic and synthetic
derivatives showed potential in vitro cytotoxicity against several colon cancer cell lines, and this activity
was often accompanied by the ability to inhibit both isoforms of topoisomerase (I and II), highlighting that these
enzymes can be promising targets for the development of new chemotherapy against CRC. Pyridine analogs were
considered the most promising for this study, while the evaluation of the real potential of natural products was
limited by the lack of information in their work. Moreover, the complexes, although promising, presented as the
main limitation the lack of selectivity.