bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Fluorescent Aptasensor Based on Mesoporous Silica Nanoparticles
for Selective and Sensitive Detection of Saxitoxin in Shellfish
Authors: Ullah Najeeb , Noureen Beenish , Zahra Qurat Ul Ain , Aziz Tariq , Shehzadi Somia , Alfaifif Mohammad Y. , Elbehairif Serag Eldin I. , Thebo Khalid Hussain , Ullah Asmat , Iqbal Haroon 
Published: November 2023

Background:
Saxitoxin (STX) stands as one of the most potent marine biotoxins, exhibiting
high lethality. Despite its severity, current treatments remain ineffective, and existing detection
techniques are limited due to ethical concerns and technical constraints.

Methods:
Herein, an innovative approach was constructed for STX detection, utilizing mesoporous
silica nanoparticles (MSN) as a foundation. This innovative, easy, and label-free aptamer (Apt)-
sensor was fabricated. Apts were employed as molecular identification probes and "gated molecules,"
while rhodamine 6G was encapsulated within particles to serve as a signal probe. In a lack of
STX, Apts immobilized on an MSN surface kept a "gate" closed, preventing signal probe leakage.
Upon the presence of STX, the "gate" opened, allowing a particular binding of Apts to STX and a
subsequent release of a signal probe.

Results:
Experimental results demonstrated a positive correlation between fluorescence intensity and
concentrations of STX within a range of 1 to 80 nM, with an exceptional limit of detection of 0.12
nM. Furthermore, the selectivity and stability of a biosensor were rigorously evaluated, validating its
reliability.

Conclusion:
This newly developed sensing strategy exhibits remarkable performance in STX detection.
Its success holds significant promise for advancing portable STX detection equipment, thereby
addressing a pressing need for efficient and ethical detection methods in combating marine biotoxin
contamination.
A Review on Biomimetic Cilia Microrobots: Driving Methods, Application
and Research Prospects
Authors: Jing Ziang , Cai Gaoshen , Pan Yufeng , Yuan Yongfeng 
Published: November 2023

Abstract:
With the development of science and technology, microrobots have been used in
medicine, biology, rescue, and many other fields. However, the microrobots have problems such
as energy and motion due to miniaturization. In order to solve the problem of the energy supply
of microrobots, researchers have provided more drive schemes for microrobots. Inspired by the
biological cilia, the biomimetic cilia have been developed and applied to microrobots to achieve
propulsion, liquid pumping, liquid mixing, and particle manipulation. This review summarizes
the different driving modes of microrobots, focusing on the application of magnetic drive and
optical drive in the field of micro-robots. The structure and function of biological cilia and biomimetic cilia are introduced. The application of biomimetic cilia microrobots in various fields is
discussed, and the current challenges and future development trends of biomimetic cilia microrobots are summarized. This review hopes to provide useful help for researchers of biomimetic
cilia microrobots
Comparison between the ECG Outcomes of Metoprolol and Bisoprolol
Authors: Almeman Ahmad Abdulrahman , Alharbi Yousef Obaid , Alwahhabi Abdulaziz Sulaiman , Almutairi Abdulaziz Abdullah , Alnasr Moayad Yousef , Almesnid Abdulrahaman 
Published: November 2023

Background:
Beta-blockers are essential agents in the management of cardiovascular
diseases, such as heart failure, acute myocardial infarction (MI), and cardiac arrhythmias. However,
there are diurnal variations in the cardioprotective effects of the subgroups as a result of
their different pharmacokinetic, pharmacodynamic, and pharmacogenetic profiles

Objectives:
We aimed to compare metoprolol and bisoprolol in terms of electrocardiogram
(ECG) outcomes.

Methods:
A retrospective cross-sectional study was conducted at Prince Sultan Cardiac Center.
The trial included 404 patients who met the inclusion criteria (204 in the metoprolol arm and 200
in the bisoprolol arm). Using case record forms that had already been created, information, such
as patient demographics, medical histories, and treatment histories, was taken from their medical
files. The most recent ECG records were also gathered. The ethical approval for this study was
obtained from Qassim ethical committee (approval number: 45-44-902).

Results:
There was no significant difference found between the patients in both arms in terms of
baseline characteristics, age, or sex.

Conclusion:
In this retrospective cross-sectional study, we have compared the effects of
metoprolol and bisoprolol beta blockers on ECG changes. The findings have indicated no difference
between metoprolol and bisoprolol groups in terms of all ECG readings, particularly
PR/ms, QTC-ms, and ventricular rate. Further studies are required to confirm these findings.
Investigating how Interleukin 6 Serum Level, Blood Group Type, and Underlying Diseases are Associated in Patients Admitted to the COVID-19 Intensive Care Unit: A Retrospective Study
Authors: Abbasi Zahra , Moghadaci Ali , Mohammadnahal Leila , Sangrizeh Faezeh Hoseini , Gholami Mohammad Hossein , Baeelashaki Reza , Hushmandi Kiavash , Raesi Rasoul , Khalilipour Asma , Dashti Shahriar 
Published: November 2023

Aims:
This study intended to examine correlations between interleukin 6 serum levels, blood group, and underlying disease in patients admitted to the COVID-19 intensive care unit.

Background:
Understanding the relationship between a patient's blood group, underlying disease(s), and the body's cytokine reactions is essential for care provision to COVID-19 patients.

Materials and Methods:
The clinical records of 31 patients admitted to an intensive care unit were analyzed using a census method. Data were collected using a researcher-developed checklist and analyzed with SPSS-22 statistical software using one-way analysis of variance and Tukey-Kramer post hoc, independent t, and multiple regression. The level of significance was set to p <0.05.

Results:
The mean serum level of interleukin 6 was significantly higher in patients with blood type B and those with two or more underlying diseases (p <0.05). The mean serum interleukin 6 levels in patients differed significantly based on the history of COVID-19 vaccine injection and the length of hospitalization (p <0.05). The mean serum interleukin 6 levels were associated with the length of COVID-19 intensive care unit stay and survival (p <0.05).

Conclusion:
Effective and timely care provision for COVID-19 patients is a top priority, which can be achieved by understanding the correlation between the body's cytokine reactions in the fight against COVID-19, blood type, and underlying diseases.
Implications for Electronic Surveys in Inpatient Settings Based on Patient Survey Response Patterns: Cross-Sectional Study
Authors: Gregory Megan E , Sova Lindsey N , Huerta Timothy R , McAlearney Ann Scheck 
Published: November 2023

Background
Surveys of hospitalized patients are important for research and learning about unobservable medical issues (eg, mental health, quality of life, and symptoms), but there has been little work examining survey data quality in this population whose capacity to respond to survey items may differ from the general population.

Objective
The aim of this study is to determine what factors drive response rates, survey drop-offs, and missing data in surveys of hospitalized patients.

Methods
Cross-sectional surveys were distributed on an inpatient tablet to patients in a large, midwestern US hospital. Three versions were tested: 1 with 174 items and 2 with 111 items; one 111-item version had missing item reminders that prompted participants when they did not answer items. Response rate, drop-off rate (abandoning survey before completion), and item missingness (skipping items) were examined to investigate data quality. Chi-square tests, Kaplan-Meyer survival curves, and distribution charts were used to compare data quality among survey versions. Response duration was computed for each version.

Results
Overall, 2981 patients responded. Response rate did not differ between the 174- and 111-item versions (81.7% vs 83%, P=.53). Drop-off was significantly reduced when the survey was shortened (65.7% vs 20.2% of participants dropped off, P<.001). Approximately one-quarter of participants dropped off by item 120, with over half dropping off by item 158. The percentage of participants with missing data decreased substantially when missing item reminders were added (77.2% vs 31.7% of participants, P<.001). The mean percentage of items with missing data was reduced in the shorter survey (40.7% vs 20.3% of items missing); with missing item reminders, the percentage of items with missing data was further reduced (20.3% vs 11.7% of items missing). Across versions, for the median participant, each item added 24.6 seconds to a survey’s duration.

Conclusions
Hospitalized patients may have a higher tolerance for longer surveys than the general population, but surveys given to hospitalized patients should have a maximum of 120 items to ensure high rates of completion. Missing item prompts should be used to reduce missing data. Future research should examine generalizability to nonhospitalized individuals.
A Penny Here, a Penny There: A Case of Managing Non-GAAP Earnings at PPG Industries
Authors: Gujarathi Mahendra , Kohlbeck Mark 
Published: November 2023

ABSTRACT
This real-world case demonstrates attempts by PPG’s controller to manage non-GAAP earnings to meet or beat the consensus analyst estimates. The case provides information regarding improper accounting adjustments made by PPG. In completing the case requirements, students decipher whether PPG used non-GAAP earnings to inform or obfuscate, determine whether certain accounting adjustments violated generally accepted accounting principles, compute the effect of accounting adjustments on non-GAAP and GAAP earnings, examine its materiality, and understand the likely motivations of the controller for recording accounting adjustments. The case also demonstrates the effect of classification shifting as a tool for managing non-GAAP earnings and exposes students to the importance of meeting or beating analyst estimates. It is appropriate for intermediate accounting and professional accounting research courses.
JEL Classifications: M41.
Plataformas digitales en la modalidad híbrida a nivel superior
Authors: Delgadillo Gómez Patricia , Ruiz Reynoso Adriana Mercedes , García Pérez Sara Lilia , Martínez Rodríguez Edim , Gutiérrez del Olmo Leisdy del Carmen 
Published: November 2023

El Centro Universitario (CU) Ecatepec, de la Universidad Autónoma del Estado de México (UAEMéx), es una institución con 27 años de servicio en la cual se imparten las carreras de ingeniería en Computación, licenciatura en Informática Administrativa, licenciatura en Psicología, licenciatura en Contabilidad y licenciatura en Administración. Utiliza herramientas digitales como Moodle, Seduca y Microsoft Teams para apoyar el proceso de enseñanza-aprendizaje. Cuenta con tres tipos de modalidades de enseñanza: escolarizada, mixta y en línea. En el marco de la suspensión de las clases presenciales, la necesidad de mantener la continuidad de los aprendizajes ha impuesto desafíos que los países han abordado mediante diferentes alternativas y soluciones en relación con los calendarios escolares y las formas de trabajo, por medios no presenciales y con diversas formas de adaptación.
Por tanto, el objetivo de este documento es visibilizar la diversidad de consecuencias que estas medidas tendrán sobre la institución educativa a corto y mediano plazo, así como plantear recomendaciones para sobrellevar el impacto de la mejor manera posible, proyectando oportunidades para el aprendizaje y la innovación en la educación posterior a la pandemia con la comunidad universitaria del CU Ecatepec.
Shifting Mandates and Climate Change Policy Capacity: The Canadian Infrastructure Case
Authors: Craft Jonathan , Howlett Michael , Crawford Mark 
Published: November 2023

Responsive policy-making on climate change
issues requires both sophisticated policy analysis as well as
an institutional structure which allows problems to be dealt
with on a multi-level and multi-sectoral basis. Designing
such policies requires a high level of policy capability in
relevant government departments and agencies matching
changing organizational mandates in the area. This paper
examines Infrastructure Canada’s evolving mandate over the
past decade and assesses whether or not its resource allocation
has matched any shifts in government expectations for
the agency due arising from climate change challenges.
Provincial data are also examined in a similar light.
The Role of Climate Change Policy Work in Canada
Authors: Wellstead Adam M. , Stedman Richard C. 
Published: November 2023

An ongoing concern with many Canada’s governments
is avoiding climate change related policy failure,
including that associated with climate change. In response,
there has been a spate of government-led climate change
vulnerability and risk assessments, studies, and strategies.
With a growing attention on developing the ‘right’ policies
and program to address climate change needs to be examined
as an important factor in ‘adaptive capacity’. As governments
turn their attention from broad strategizing to
policy-making, we argue that a consideration of the often
overlooked micro-level and seemingly routine government
based capacity—especially the advice needed to formulate
and implement policy changes—is required. A high level of
policy capacity is an important factor in avoiding policy
failures. The questionnaire was delivered through a webbased
survey of 1469 Canadian provincial and territorial
government policy analysts working in nine provinces and
three territorial jurisdictions in the climate change, environmental,
financial, forestry, natural resource, infrastructure,
transportation, and water sectors. A comparison of
mean scores across key indicators of policy work was conducted.
A number of policy implications were raised. First,
those in financial sector do very little climate change policy
work. Second, the fracturing of roles in those departments
responsible for forestry reflects the complexity of the climate
change issue and a developed division of labour. Those who
identified with forestry sector, under performed despite their
concern about climate change, in terms of key policy tasks,
the level of complexity that the issues were addressed and a
low level engagement with stakeholders with those outside
of government. Policy capacity was also undermined with a
view that departments were committed vis a vis their mission
statements but that this commitment was not reflected
in their daily operations.
Ibuprofeno induz toxicidade e mutagenicidade em diferentes organismos modelo expostos a concentrações ambientalmente relevantes e não relevante
Authors: Silva Leonardo Mendes da , Dutra Vanessa de Souza Vieira , Nascimento Graziele Vanessa Assis , Paula Paola Nádila Carolina Resende de , Silva Fábio Júnio da 
Published: November 2023

O aumento do consumo de produtos farmacêuticos, como o ibuprofeno, tem levado à sua presença generalizada no meio ambiente, representando riscos para a cadeia trófica. A fim de monitorar a presença de contaminantes farmacêuticos emergentes, é comum o uso de minhocas (Eisenia fetida) e alface (Lactuca sativa) para o monitoramento ambiental. Este estudo investigou os efeitos da exposição ao ibuprofeno em concentrações ambientalmente relevantes (0,02 e 0,20 mg/L-1) e não relevante (600 mg/L-1) sobre a mortalidade das minhocas, germinação, desenvolvimento inicial de plântulas e efeitos sobre o ciclo celular de Lactuca sativa. Os resultados demostram que concentrações ambientalmente relevantes não foram capazes de induzir mortalidade em minhocas ou reduzir a porcentagem de germinação das sementes de alface. Tais parâmetros foram afetados somente pela concentração não relevante, a qual promoveu 100% de mortalidade e reduziu a germinação em 61,67%. Apesar de não ter afetado a germinação, a concentração de 0,02 mg/L-1 reduziu o comprimento das raízes das plântulas em 18,72% e o comprimento da parte aérea em 20,72%. Além disso, foi constatado que o ibuprofeno pode afetar negativamente a integridade do material genético, induzindo a formação de micronúcleos em células da raiz, indicando sua mutagenicidade. Na concentração de 0,02 mg/L-1, a frequência de micronúcleos foi de 0,68%, e na concentração de 0,20 mg/L-1, foi de 1,33%. Isso sugere que a presença de ibuprofeno no ambiente pode representar risco para a biodiversidade, ressaltando a necessidade de medidas para minimizar a exposição ao composto e garantir seu uso seguro e responsável.
Palavras-chave: Descarte de Medicamentos; Lactuca sativa; Modelos vegetais; Micronúcleos; Poluição hídrica.
School district investments in general skills: The case of principal residency programs
Authors: Nguyen Minh , Rivkin Steven G. , Sartain Lauren , Schiman Jeffrey C. 
Published: November 2023

Abstract
Districts are investing more in school leadership, including the implementation of residency training programs for aspiring principals. There is limited evidence about the district return on these investments, and none in the context in which principal hiring is decentralized at the school level. This paper develops a model highlighting the conditions under which districts benefit from investments in general leadership skills and examines the residency program in the Chicago Public Schools (CPS). The event-study analysis that addresses treatment effect heterogeneity finds that principals who complete a residency are significantly more effective at raising achievement. Although the leadership skills gained through the residency are likely to make a principal more valuable to districts outside of CPS, the large majority of residents remain in CPS despite the absence of salary premia for completion of a residency or high performance. These findings suggest the presence of transition costs that enable CPS to retain more effective, residency-trained principals without having to increase pay, thereby realizing some of the return on the investment in general skills.
The Relationship Between Personality Traits, Career Adaptability, and Gender: Evidence of Professionals from Brazilian Technology Incubators
Authors: De Castro Beatriz  Leite Gustmann , Da Silva Deoclécio Junior Cardoso , Stertz Estefana da Silva , Costa Vânia Medianeira Flores , Lopes Luis Felipe Dias , De Sá Clayton Pereira 
Published: November 2023

Purpose: This study aimed to investigate the relationship between personality traits and career adaptability, verifying the existence of the influence of gender in professionals from technology incubators in southern Brazil.

Method: Through a quantitative study, the collection of primary data was carried out with a sample of 310 professionals from technology incubators in southern Brazil, where the relationships of the outlined hypotheses were evaluated through structural equation modeling.

Results: Through data analysis, it was verified the existence of relationships between the analyzed constructs, in which the strongest correlations were between the Agreeableness with Emotional Stability and Extraversion, Trust with Cooperation and Control with Concern dimensions.

Conclusion: Few studies have addressed the issue of career adaptability and personality traits in the technological environment, even more so when it comes to verifying the issue of gender difference in this space. In this sense, this study contributed to in interrelation of the approaches of career adaptability and personality traits, adding the relative gender to the field of technology since this environment is still strictly masculinized. From a practical point of view, it explains the importance of organizational policies that consolidate the amplitude of female participation and representation, especially in strategic positions in technology, raising reflections for managers about diversity and gender equity in an increasingly digital world.
Pengaruh Gaya Kepemimpinan, Motivasi Kerja, Budaya Organisasi terhadap Kepuasan Kerja Karyawan
Authors: Mulyono Anastasia Devindra , Ekawati Sanny 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan, motivasi kerja, dan budaya organisasi terhadap kepuasan kerja karyawan. Penelitian ini menggunakan desain kausal dengan pendekatan kuantitatif. Sampel dalam penelitian ini adalah seluruh karyawan perusahaan yang berjumlah 52 orang. Teknik pemilihan sampel yang digunakan merupakan sampel jenuh. Instrumen penelitian menggunakan kuesioner dalam bentuk google form. Analisis data penelitian menggunakan software SmartPLS versi 3.3.9. Hasil penelitian ini menunjukkan bahwa motivasi kerja memiliki pengaruh positif dan signifikan terhadap kepuasan kerja karyawan. Sedangkan gaya kepemimpinan dan budaya organisasi memiliki pengaruh yang positif namun tidak signifikan terhadap kepuasan kerja karyawan.

This study aimed to determine the effect of leadership style, work motivation, and organizational culture on employee job satisfaction. This study used a causal design with a quantitative approach. The sample in this study were all company employees, totaling 52 people. The sample selection technique used a saturated sample. The research instrument used a google form questionnaire. Analysis of research data using SmartPLS software version 3.3.9. The results of this study indicate that work motivation has a positive and significant influence on employee job satisfaction. Meanwhile, leadership style and organizational culture have a positive but insignificant effect on employee job satisfaction.
Pengaruh Orientasi Kewirausahaan, Orientasi Pasar dan Inovasi terhadap Kinerja UMKM Bidang Fashion
Authors: Daniella Catherine , Utama Louis 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh orientasi kewirausahaan, orientasi pasar dan inovasi terhadap kinerja UMKM bidang fashion di Tanah Abang. Sampel yang digunakan dalam penelitian ini 110 responden pemilik UMKM bidang bidang fashion di Tanah Abang. Teknik pengambilan sampel menggunakan metode purposive sampling. Teknik pengumpulan data menggunakan kuisioner yang disebar langsung ke pemilik usaha. Teknik pengolahan data dalam penelitian ini dibantu dengan program SmartPLS 3.0. Hasil dari penelitian ini menunjukan orientasi kewirausahaan dan inovasi memiliki pengaruh positif dan signifikan terhadap kinerja UMKM, sedangkan orientasi pasar tidak memiliki pengaruh secara signifikan terhadap kinerja UMKM.

This study aims to determine the effect of entrepreneurial orientation, market orientation and innovation on the performance of SMEs in the fashion sector in Tanah Abang. The sample used in this study was 110 respondents who own SMEs in the fashion sector in Tanah Abang. The sampling technique used purposive sampling method. The data processing technique in this study was assisted by the SmartPLS 3.0 program. The results of this study show that entrepreneurial orientation and innovation have a positive and significant effect on the performance of MSMEs, while market orientation does not have a significant effect on the performance of MSMEs.