bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety Behavior and Transition Shock among Newly Graduated Nurses: The Mediating Role of Feedback-Seeking Behavior
Authors: Zhang Yan , Yu Xilin , Lu Xiaohong , Tang Yalin , Jiang Wenbin , Wei Qiaofeng , Wei Lili 
Published: October 2023

Aim. To determine the relationship between transition shock and safety behavior among newly graduated nurses (NGNs) and explore the mediating role of feedback-seeking behavior. Background. The safety behavior of NGNs plays a vital role in improving patient safety in clinical situations. The direct effect of the transition shock experienced by these nurses on safety behavior remains limited, and little is known about the mediating effect of feedback-seeking behavior. Methods. A descriptive correlational research design was conducted with a cross-sectional sample of nurses in China using an online survey. A convenience sample of 575 nurses from 17 hospitals completed the questionnaires. Correlation analysis and structural equation modeling were used to examine the hypotheses. Results. The sampled NGNs’ safety behavior score was 55.35 ± 5.46. Their transition shock was negatively associated with safety behavior (β = −0.225,

p

< 0.001). In contrast, feedback-seeking behavior was positively related to safety behavior (β = 0.502,

p

< 0.001). The feedback-seeking behavior partially mediated the relationship between transition shock and safety behavior, and the mediating effect was 58.29%. Conclusions. The results emphasized that the relationship between NGNs’ transition shock and safety behavior is mediated by feedback-seeking behavior. Implications for Nursing Management. Interventions focusing on transition shock relief could help improve NGNs’ safety behavior. This study highlights the importance of encouraging feedback-seeking behavior to improve patient safety outcomes, especially for junior nurses. It can therefore be assumed that the nursing managers’ training of NGNs in special skills, such as feedback-seeking, may be conducive to their positive coping and contribute to forming safety behaviors.
Impact of Rare and Multiple Concurrent Gene Fusions on Diagnostic DNA Methylation Classifier in Brain Tumors
Authors: Galbraith Kristyn , Serrano Jonathan , Shen Guomiao , Tran Ivy , Slocum Cheyanne C. , Ketchum Courtney , Abdullaev Zied , Turakulov Rust , Bale Tejus , Ladanyi Marc , Sukhadia Purvil , Zaidinski Michael , Mullaney Kerry , DiNapoli Sara , Liechty Benjamin L. , Barbaro Marissa , Allen Jeffrey C. , Gardner Sharon L. , Wisoff Jeffrey , Harter David , Hidalgo Eveline Teresa , Golfinos John G. , Orringer Daniel A. , Aldape Kenneth , Benhamida Jamal , Wrzeszczynski Kazimierz O. , Jour George , Snuderl Matija 
Published: October 2023

Abstract

DNA methylation is an essential molecular assay for central nervous system (CNS) tumor diagnostics. While some fusions define specific brain tumors, others occur across many different diagnoses. We performed a retrospective analysis of 219 primary CNS tumors with whole genome DNA methylation and RNA next-generation sequencing. DNA methylation profiling results were compared with RNAseq detected gene fusions. We detected 105 rare fusions involving 31 driver genes, including 23 fusions previously not implicated in brain tumors. In addition, we identified 6 multi-fusion tumors. Rare fusions and multi-fusion events can impact the diagnostic accuracy of DNA methylation by decreasing confidence in the result, such as BRAF, RAF, or FGFR1 fusions, or result in a complete mismatch, such as NTRK, EWSR1, FGFR, and ALK fusions.

Implications:
DNA methylation signatures need to be interpreted in the context of pathology and discordant results warrant testing for novel and rare gene fusions.
Effect of Dapagliflozin on 6-Minute Walk Distance in Heart Failure With Preserved Ejection Fraction: PRESERVED-HF
Authors: Lewis Gregory D. , Gosch Kensey , Cohen Laura P. , Nassif Michael E. , Windsor Sheryl L. , Borlaug Barry A. , Kitzman Dalane W. , Shah Sanjiv J. , Khumri Taiyeb , Umpierrez Guillermo , Lamba Sumant , Sharma Kavita , Khan Sadiya S. , Kosiborod Mikhail N. , Sauer Andrew J. 
Published: October 2023

BACKGROUND:
Heart failure with preserved ejection fraction is associated with significant functional limitations, yet treatments for improving exercise performance have been elusive. We sought to explore the association between prespecified patient characteristics and changes in 6-minute walk distance that constitute a clinically significant response to dapagliflozin.

METHODS:
We performed a responder analysis to understand patient characteristics associated with clinically meaningful improvement in 6-minute walk test (6MWT) distance ≥15 m among patients randomized to 12 weeks of dapagliflozin versus placebo in the double-blind PRESERVED-HF trial (Effects of Dapagliflozin on Biomarkers, Symptoms and Functional Status in Patients With Preserved Ejection Fraction Heart Failure).

RESULTS:

A total of 289 randomized patients had 6MWT distance completed at baseline and 12 weeks. Patients randomized to dapagliflozin improved walking distance by ≥15 m more frequently than those on placebo (n=64, 44% versus n=48, 34%). After adjusting for baseline covariates, patients randomized to dapagliflozin were more likely to experience a clinically meaningful improvement in 6MWT distance compared with those that received placebo (adjusted odds ratio, 1.66 [95% CI, 1.00–2.75];
P
=0.05). Dapagliflozin-treated patients were also less likely to have a ≥15 m reduction in 6MWT distance compared with placebo-treated patients (adjusted odds ratio, 0.56 [95% CI, 0.33–0.94];
P
=0.03). These results were consistent across all prespecified subgroups (all
P
values for interaction were not significant).

CONCLUSIONS:
Compared with those on placebo, patients with heart failure with preserved ejection fraction randomized to dapagliflozin were more likely to experience a clinically meaningful improvement and less likely to experience a deterioration in physical function over 12 weeks as measured by 6MWT distance. Beneficial response to dapagliflozin was consistent across prespecified subgroups.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03030235.
High sensitivity mapping of brain-wide functional networks in awake mice using simultaneous multi-slice fUS imaging
Authors: Bertolo Adrien , Ferrier Jeremy , Cazzanelli Silvia , Diebolt Samuel , Tanter Mickael , Pezet Sophie , Pernot Mathieu , Osmanski Bruno-Félix , Deffieux Thomas 
Published: October 2023

Abstract
Functional ultrasound (fUS) has received growing attention in preclinical research in the past decade, providing a new tool to measure functional connectivity (FC) and brain task-evoked responses with single-trial detection capability in both anesthetized and awake conditions. Most fUS studies rely on 2D linear arrays to acquire one slice of the brain. Volumetric fUS using 2D matrix or row-column arrays has recently been demonstrated in rats and mice but requires invasive craniotomy to expose the brain due to a lack of sensitivity. In a previous study, we proposed the use of motorized linear arrays, allowing imaging through the skull in mice for multiple slices with high sensitivity. However, the tradeoff between the field of view and temporal resolution introduced by motorized scanning prevents acquiring brain-wide resting-state FC data with a sufficient volume rate for resting-state FC analysis. Here, we propose a new hybrid solution optimized and dedicated to brain-wide transcranial FC studies in mice, based on a newly developed multi-array transducer allowing simultaneous multi-slicing of the entire mouse cerebrum. We first demonstrate that our approach provides a better imaging quality compared to other existing methods. Then, we show the ability to image the whole mouse brain non-invasively through the intact skin and skull during visual stimulation under light anesthesia to validate this new approach. Significant activation was detected along the whole visual pathway, at both single and group levels, with more than 10% of augmentation of the cerebral blood volume (CBV) signal during the visual stimulation compared to baseline. Finally, we assessed resting-state FC in awake head-fixed animals. Several robust and long-ranged FC patterns were identified in both cortical and sub-cortical brain areas, corresponding to functional networks already described in previous fMRI studies. Together, these results show that the multi-array probe is a valuable approach to measure brain-wide hemodynamic activity in mice with an intact skull. Most importantly, its ability to identify robust resting-state networks is paving the way towards a better understanding of the mouse brain functional organization and its breakdown in genetic models of neuropsychiatric diseases.
Modulation of Visually Induced Self-motion Illusions by α Transcranial Electric Stimulation over the Superior Parietal Cortex
Authors: Harquel Sylvain , Cian Corinne , Torlay Laurent , Cousin Emilie , Barraud Pierre-Alain , Bougerol Thierry , Guerraz Michel 
Published: October 2023

Abstract
The growing popularity of virtual reality systems has led to a renewed interest in understanding the neurophysiological correlates of the illusion of self-motion (vection), a phenomenon that can be both intentionally induced or avoided in such systems, depending on the application. Recent research has highlighted the modulation of α power oscillations over the superior parietal cortex during vection, suggesting the occurrence of inhibitory mechanisms in the sensorimotor and vestibular functional networks to resolve the inherent visuo-vestibular conflict. The present study aims to further explore this relationship and investigate whether neuromodulating these waves could causally affect the quality of vection. In a crossover design, 22 healthy volunteers received high amplitude and focused α-tACS (transcranial alternating current stimulation) over the superior parietal cortex while experiencing visually induced vection triggered by optokinetic stimulation. The tACS was tuned to each participant's individual α peak frequency, with θ-tACS and sham stimulation serving as controls. Overall, participants experienced better quality vection during α-tACS compared with control θ-tACS and sham stimulations, as quantified by the intensity of vection. The observed neuromodulation supports a causal relationship between parietal α oscillations and visually induced self-motion illusions, with their entrainment triggering overinhibition of the conflict within the sensorimotor and vestibular functional networks. These results confirm the potential of noninvasive brain stimulation for modulating visuo-vestibular conflicts, which could help to enhance the sense of presence in virtual reality environments.
Virtual Groups and the Triggering of Armed Conflicts
Authors: Thøgersen Marie 
Published: October 2023

Abstract
The article examines how virtual groups can trigger an armed conflict, and thus, the application of international humanitarian law (ihl). The emergence of non-State actors as central players in cyberspace, together with the increasing use of cyber operations in conflicts, makes the regulation of non-State actors in armed conflicts a topical issue. The triggering provisions in ihl require a level of organization of non-State groups, which do not necessarily resonate with the realities among virtual groups. To determine if the triggering provisions allow for a reinterpretation to fit better the potentially differently structured virtual groups, the article scrutinizes the legal bases for the organization requirements in the respective provisions and identities the underlying rationales. The article concludes that the legal bases for the organization requirement in the three provisions are distinct, but that none of them currently allows for reinterpretation.
The Dark Knowledge Problem: Why Public Justifications are Not Arguments
Authors: Donahue Sean 
Published: October 2023

Abstract
According to the Public Justification Principle, legitimate laws must be justifiable to all reasonable citizens. Proponents of this principle assume that its satisfaction requires speakers to offer justifications that are representable as arguments that feature premises which reasonable listeners would accept. I develop the concept of dark knowledge to show that this assumption is false. Laws are often justified on the basis of premises that many reasonable listeners know, even though they would reject these premises on the basis of the further considerations that speakers implicitly rely on for their support. Accommodating the fact of dark knowledge requires us to consider the civic virtue of speakers to be more important for public justification than the acceptability of their arguments to reasonable citizens. I sketch an alternative conception of public justification that incorporates these results and argue that it provides a rationale for ignoring the otherwise sound contributions of some participants in political deliberation.
Hybrid War and Colour Revolutions in Hong Kong: A Means to Achieve Regime Change in China?
Authors: Marples Agathe 
Published: October 2023

Abstract
Where the limits of today’s international order prevent direct and costly confrontations between great powers, hybrid war allows for the manipulation of situations from afar to achieve desired outcomes, such as through Colour Revolutions. While the concept of hybrid war has been thoroughly researched in the context of foreign interventions in the Middle East and Eastern Europe, there is no substantial literature applied to the case of Hong Kong. This article investigates China’s claims that there was a ‘black hand’ behind Hong Kong’s protests – specifically the 2014 Umbrella Movement, 2019 Anti-elab protests, and 2020 nsl protests – determining the extent and role of foreign forces there. Using a set of theoretical propositions derived from a theoretical framework and a narrative explanation of how factors affect mobilisation in social movements, a macro-causal analysis about the role of external forces in Hong Kong is determined. Ultimately, this article alludes to the fact that the U.S. and other foreign forces are waging a hybrid war against China, utilising the Hong Kong social movements to achieve indirect regime change.
CAIPEEX: Indian Cloud Seeding Scientific Experiment
Authors: Prabhakaran Thara , Murugavel P. , Konwar Mahen , Malap Neelam , Gayatri K. , Dixit Shivsai , Samanta Soumya , Chowdhuri Subharthi , Bera Sudarsan , Varghese Mercy , Rao J. , Sandeep J. , Safai P. D. , Sahai A. K. , Axisa Duncan , Karipot A. , Baumgardner Darrel , Werden Benjamin , Fortner Ed , Hibert Kurt , Nair Sathy , Bankar Shivdas , Gurnule Dinesh , Todekar Kiran , Jose Jerry , Jayachandran V. , Soyam Pawan S. , Gupta Abhishek , Choudhary Harish , Aravindhavel  , Kantipudi Suresh Babu , Pradeepkumar P. , Krishnan R. , Nandakumar K. , DeCarlo Peter F. , Worsnop Doug , Bhat G. S. , Rajeevan M. , Nanjundiah Ravi 
Published: October 2023

Abstract
The demand for effective methods to augment precipitation over arid regions of India has been increasing over the past several decades as the changing climate brings warmer average temperatures. In the fourth phase of the Cloud Aerosol Interaction and Precipitation Enhancement Experiment (CAIPEEX IV), a scientific investigation was conducted over a rain-shadow region of the Western Ghats mountains in India. The primary objective was to investigate the efficacy of hygroscopic seeding in convective clouds and to develop a cloud seeding protocol. CAIPEEX IV followed the World Meteorological Organization (WMO) recommendations in a peer-reviewed report with physical, statistical, and numerical investigations. The initial results of the campaign in the monsoon period of 2018 and 2019 with two instrumented aircraft, a ground-based dual-polarization C-band radar, a network of rain gauges, radiosondes, and surface aerosol measurements are reported here. The hygroscopic seeding material was detected in cloud droplets and key cloud microphysical processes in the seeding hypothesis were tracked. The formidable challenges of assessing seeding impacts in convective clouds and the results from 150 seed and 122 no-seed samples of randomized experiments are illustrated. Over 5,000 cloud passes from the airborne campaign provided details about the convective cloud properties as the key indicators for a seeding strategy and the evaluation protocol. The experimental results suggest that cloud seeding can be approached scientifically to reduce uncertainty. The results from this study should interest the scientific community and policymakers concerned with climate change’s impact on precipitation and how to mitigate rainfall deficiencies.
Variable Rainfall over Steady SST: The Effect of the Free Troposphere on Surface Pressure in the East Pacific
Authors: Bunge Isabelle , Sobel Adam , Biasutti Michela , Wang Shuguang 
Published: October 2023

Abstract
Surface winds and precipitation over the tropical oceans are related to sea surface temperature (SST) through multiple mechanisms. Greater SST is associated with greater conditional instability, which in turn is more conducive to deep convection. The associated mass and flow responses can extend to the surface, via associated pressure gradients imprinted on the top of the planetary boundary layer (PBL). SST also influences surface pressure and wind directly through its control over PBL temperature, as explained by Lindzen and Nigam. The authors examine the relative magnitudes of these two influences over the eastern tropical Pacific on subseasonal precipitation variability during northern summer, when and where SST gradients are largest and the direct influence via PBL temperature is expected to be strongest. Geopotential at 1000 hPa is partitioned into two components: the geopotential at the PBL top (the PBL top is chosen to be 850 hPa, supported by an analysis of the vertical structure of geopotential and temperature) and the PBL thickness. These fields are composited on quintiles of daily ITCZ precipitation both with and without a high-pass filter that isolates subseasonal time scales. The PBL thickness varies little between the highest and lowest precipitation quintiles, while the PBL top geopotential varies much more. This supports a view in which the direct contribution of SST to the surface pressure and flow fields, including the associated PBL convergence over sharp SST maxima, can be viewed as a steady forcing on the rest of the column, while free-tropospheric transients contribute most of the variability associated with precipitation on subseasonal time scales.
A Comparison of 3DEnVar and 4DEnVar for Convective-Scale Direct Radar Reflectivity Data Assimilation in the Context of a Filter and a Smoother
Authors: Yang Yue , Wang Xuguang 
Published: October 2023

Abstract
The Gridpoint Statistical Interpolation (GSI)-based four- and three-dimensional ensemble–variational (4DEnVar and 3DEnVar) methods are compared as a smoother and a filter, respectively, for rapidly changing storms using the convective-scale direct radar reflectivity data assimilation (DA) framework. Two sets of experiments with varying DA window lengths (WLs; 20, 40, 100, and 160 min) and radar observation intervals (RIs; 20 and 5 min) are conducted for the 5–6 May 2019 case. The RI determines the temporal resolution of ensemble perturbations for the smoother and the DA interval for the filter spanning the WL. For experiments with a 20-min RI, evaluations suggest that the filter and the smoother have comparable performance with a 20-min WL; however, extending the WL results in the outperformance of the filter over the smoother. Diagnostics reveal that the degradation of the smoother is attributed to the increased degree of nonlinearity and the issue of time-independent localization as the WL extends. Evaluations for experiments with different RIs under the same WL indicate that the outperformance of the filter over the smoother diminishes for most forecast hours at thresholds of 30 dBZ and above when shortening the RI. Diagnostics show that more frequent interruptions of the model introduce model imbalance for the filter, and the increased temporal resolution of ensemble perturbations enhances the degree of nonlinearity for the smoother. The impact of model imbalance on the filter overwhelms the enhanced nonlinearity on the smoother as the RI reduces.

Significance Statement
The background uncertainties of rapidly changing storms suffer from fast error growth and high degrees of nonlinearities during the data assimilation (DA) period. Two variants of the ensemble-based DA method can account for such temporal evolution. The smoother uses background ensemble from multiple observation times over an assimilation period to estimate the propagation of statistics. The filter frequently calculates the statistics at multiple observation times over the same period. Current comparisons of the smoother and the filter were mostly performed using simple models; however, unknowns remain for convection-allowing forecasts with additional complexities. This study compares the filter and the smoother for the convective-scale analysis and prediction using a real-data study and finds that the comparison varies with the assimilation period and the observation interval.
Biomechanical effects of iatrogenic muscle-ligaments complex damage on adjacent segments following posterior lumbar interbody fusion: A finite element analysis
Authors: Wei Wei , Wang Tianhao , Li Jian , Liu Jianheng , Mao Keya , Pan Chun’ang , Li Hui , Zhao Yongfei 
Published: October 2023

Objective: To analyze the biomechanical effects of proximal iatrogenic muscle-ligaments complex (MLC) damage on adjacent segments following posterior lumbar interbody fusion (PLIF) by finite element (FE) analysis. Methods: The multifidus muscle force was loaded in the validated intact lumbosacral finite element model. Based on whether undergoing PLIF or the proximal MLC damage, three models were established. Range of motion (ROM) and the maximum von Mises (VM) stress of adjacent segments were analyzed, as well as the average muscle force and work capacity in four loading directions. Results: PLIF results in significant changes in ROM and stress. ROM changed significantly in the upper adjacent segment, the PLIF model changed the most in extension, and the largest change in the lower adjacent segment occurred after MLC damage. The VM stress of the upper adjacent segment occurred in extension of the PLIF model, and that of the lower adjacent segment occurred in rotation after MLC damage. In flexion, ROM, and stress of the damaged MLC fusion model were significantly increased compared with the normal and PLIF models, there was a stepwise amplification. The average muscle force comparison of three models was 5.8530, 12.3185, and 13.4670 N, respectively. The total work capacity comparison was close to that of muscle force. Conclusion: PLIF results in increased ROM and the VM stress of adjacent segments, the proximal MLC damage will aggravate this change. This may increase the risk of ASD and chronic low back pain. Preserving the proximal MLC reduces the biomechanical effects on adjacent segments.