bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrence of familial Mediterranean fever and Behçet’s disease: a case report and review of the literature
Authors: Mir Adhora , Ivory Catherine , Cowan Juthaporn 
Published: October 2023

Abstract
Background
Familial Mediterranean fever and Behçet’s disease are distinct disorders that are prevalent in the Mediterranean and Middle Eastern populations. They are characterized by unprovoked inflammatory episodes caused by overexpression of proinflammatory cytokines. Although reported previously, the overlapping presentation of familial Mediterranean fever and Behçet’s disease remains uncommon.

Case presentation
A 46-year-old Lebanese–Canadian man who presented with recurrent oral and genital ulcers, polyarticular synovitis, ocular swelling, recurrent infections, and fevers was later found to have heterozygous mutations of pathogenic MEFV c.2080A > G (p. Met 694Val) and c.2082G > A (p.Met694IIe) genes indicating familial Mediterranean fever. He was treated with prednisone, colchicine, and azathioprine, with inadequate symptoms control. Treatment was complicated by recurrent infections.

Conclusions
Our case contributes to the growing literature demonstrating the presentation of predominantly Behçet’s disease-like features in the setting of diagnosis of familial Mediterranean fever. These findings emphasize that clinicians should be aware that patients with familial Mediterranean fever may present with Behçet’s disease-like clinical manifestations.
Childhood immunization delay during the first wave of COVID-19 in an urban area of Sangli district from Maharashtra, India: a cross-sectional study
Authors: Dhanawade S. S. , Kawade R. V. , Waghachavare V. B. 
Published: October 2023

AbstractBackgroundCOVID-19-related lockdowns had resulted in overburdening on health services. The lockdowns along with anxiety of the disease have resulted in delay in routine vaccination of many under-5 children. The current study was undertaken to understand the extent of the delay in under-5 vaccination during COVID-19-related lockdown in March-December 2020.MethodsIt was a cross-sectional study conducted during January-December 2021. Study population was under five children due for vaccination during the first COVID-19 lockdown at March-December 2020. Vaccination cards were used to confirm the status of vaccination, and questionnaire was used to study the attitude of parents towards vaccination and reasons for delay in vaccination, if any. The calculated sample size was 1434. But cluster random sampling method was applied; hence, 2274 subjects were included in the study. Statistical analysis was done using IBM SPSS-22™, using descriptive statistics and chi-squared test.ResultsPercentages of children with delayed vaccination ranged from lowest for “at birth dose” (12.47%) to highest for “9th month dose, i.e. MR vaccine” (54.29%). Majority of parents stated lockdown and risk of COVID-19 infection as to be reason of the delay in vaccination. There was no uniform association between vaccination delay and attitude of parents towards vaccination.ConclusionCOVID-19 pandemic and subsequent lockdown are the reasons stated by majority of parents with delayed vaccination in their children. This could be important lesson to plan for such contingencies for developing health services in future.
Efficient in vitro oxaliplatin delivery with functionalized single-walled carbon nanotube for enhanced colon cancer treatment
Authors: Randive Dheeraj S. , Shejawal Kiran P. , Bhinge Somnath D. , Bhutkar Mangesh A. , Jadhav Namdeo R. , Patil Sandeep B. , Nadaf Sameer J. 
Published: October 2023

Abstract
Background
Site-specific transport of medicinal products to malignant cells and tissues is an intriguing area since it has an ability to safeguard healthy cells. Selective upregulation of folate receptors on colon cancer cells is usual. Consequently, folate receptors have become one of extensively studied target moieties for targeting the delivery of chemotherapeutics. Hence, the study aimed to anchor folic acid, chitosan and oxaliplatin to the functionalized nanotube (FA-CHI-FSWCNT-OXA) for targeting folate receptors on colon cancer cells. The purification process of single-walled carbon nanotubes (SWCNTs) involved the use of an ultrasonic-assisted acid digestion method. The developed complex was evaluated using FTIR, DSC, SEM, XRD and in vitro dissolution studies. SRB and MTT assays were used to assess in vitro cytotoxicity of oxaliplatin and FA-CHI-FSWCNT-OXA) against HT29 and COLO320DM cell lines. Further, progression of apoptosis in cells was investigated using flow cytometry.

Results
The FTIR results corroborated drug attachment over carbon nanotube (CNT), whereas the TEM results validated the nanosizing (1–300 nm) of the developed system. Drug entrapment in CNT was found to be 93.43 ± 1.65%, and in vitro drug release was found to be 94.73 ± 0.90% after 24 h. The complex reduced viability of 92.35 ± 0.942% cells than oxaliplatin’s 66.58 ± 0.38% inhibition, revealed by MTT assay. In the SRB assay, the developed system showed 91.22 ± 0.90% inhibition, whereas oxaliplatin showed 76.69 ± 0.52% inhibition against HT29 cells.

Conclusions
Conclusively, the developed system exhibited better cytotoxicity effects as compared with plain oxaliplatin. Our findings are suggestive of the potential development of CNT-anchored antineoplastic agents for target-specific delivery.
Environmental Characteristic of Phyllophorus sp. (Echinodermata, Holothuroidea, Phyllophoridae) Habitat in the Madura Strait, Indonesia
Authors: Widianingsih Widianingsih , Hartati Retno , Endrawati Hadi 
Published: October 2023

Information on the environmental characteristics of many sea cucumber habitat is limited, despite these species exhibiting rapid exploitation and may lead to depletion. The present study combined a survey on many seawaters and sediment characteristics of habitat valuable aspidochirote holothurian, Sea Ball Cucumber, Phyllophorus sp. to compare with location with no sea cucumber in Madura Strait, Indonesia. Data from detailed surveys were used to compare both locations with measures of physical and chemical seawater parameters including temperature, salinity, dissolved oxygen, pH, phosphate, nitrate, ammonia, chlorophyll-a, total suspended solids, light transparency, and depth of water. The comparison was also carried out on physical and chemical parameters of surface sediment, i.e. phosphate, nitrate, ammonia, chlorophyll-a, grain size, total organic matter, and carbon-organic content. The data then were analyzed using Mann-Whitney U-Non Parametric Test with SPSS v. 16. The result revealed that there were significant differences between sediment characteristics of Sea Ball Cucumber habitat and no Sea Ball cucumber location, but not for seawater. Seawater parameter value in Madura Strait showed in the range required for its life. This analyzes proved the importance of sediment characteristics for Phyllophorus sp. As benthic deposit feeders, they did not only utilize substrate underneath the body for its habitat but also primarily to supply their natural food.
Analisis Kandungan Logam Berat Kadmium (Cd) pada Gastropoda Conus spp. di Hamparan Lamun Perairan Pesisir Manokwari, Propinsi Papua Barat
Authors: Karubuy Randy Imanuel Sandy , Manan Jemmy , Manangkalangi Emmanuel , Sembel Luky , Saleky Dandi 
Published: October 2023

Manokwari coastal waters are one of the coastal areas that experience very rapid development of development activities from year to year. This condition allows the input of waste such as heavy metal cadmium (Cd) into the waters of Manokwari. This research was conducted in the coastal area of Manokwari (BLK Beach, Lemon Island, and Tanjung Manggewa) for three months (February-April 2020). The purpose of this study was to describe the concentration of heavy metal cadmium (Cd) in Gastropod Conus on the Manokwari Coast and to determine the relationship between heavy metal content of cadmium (Cd) in Conus with shell size, wet weight, and dry weight. Data analysis includes Atomic Absorption Spectrophotometer (AAS), linear regression, and descriptive analysis. Based on the research results obtained, the average content of cadmium in Conus in Manokwari waters is 0.06-0.22 mg/kg. The heavy metal content in Conus is still below the specified threshold so it is still fit for consumption. The relationship between the heavy metal content of Cd in Conus with shell length, wet weight, and dry weight are positive with the regression equation successively y = -0.065 + 0.002x, y = 0.054 + 0.005x, and y = 0.061 + 0.014x which shows that the content Heavy metal Cd in Conus is influenced by shell length, wet weight, and dry weight. Perairan pesisir Manokwari merupakan salah satu wilayah pesisir yang mengalami perkembangan kegiatan pembangunan yang sangat pesat dari tahun ke tahun. Kondisi ini memungkinkan adanya masukan limbah seperti logam berat kadmium (Cd) ke perairan Manokwari. Penelitian ini dilakukan di wilayah pesisir Manokwari (Pantai BLK, Pulau Lemon, dan Tanjjung Manggewa) selama tiga bulan (Februari-April 2020). Tujuan dilakukannya penelitian ini untuk mendeskripsikan konsentrasi logam berat kadmium (Cd) pada Gastropoda Conus di Pesisir Manokwari serta mengetahui hubungan kandungan logam berat kadmium (Cd) dalam Conus dengan ukuran cangkang, berat basah, dan berat kering. Analisis data meliputi Spektrofotometer Serapan Atom (SSA), regresi linear, dan analisis deskriptif. Berdasarkan hasil penelitian yang didapatkan, kandungan rata-rata kadmium pada Conus di perairan Manokwari yaitu sebesar 0,06-0,22 mg/kg. Kandungan logam berat dalam Conus masih dibawah ambang yang ditentukan sehingga masih layak untuk dikonsumsi. Hubungan antara kandungan logam berat Cd dalam Conus dengan panjang cangkang, berat basah dan berat kering adalah positif dengan persamaan regresi berturut-turut y = -0,065 + 0,002x, y = 0,054 + 0,005x dan y = 0,061 + 0,014x yang menunjukan bahwa kandungan logam berat Cd dalam Conus dipengaruhi oleh panjang cangkang, berat basah dan berat kering.
Pemanfaatan Citra Satelit Aqua-MODIS untuk Pemantauan Dinamika Spasio-Temporal Produktivitas Primer Bersih di Perairan Laut Jawa
Authors: Anugrah Alfandy Putra , Hidayah Zainul , As-Syakur Abdurrahman , Rachman Herlambang Aulia 
Published: October 2023

The Java Sea is an area with the highest rate of exploitation of fishery resources in Indonesia. As much as 32% of the total national fishery production or 2.2 million tons has come from catches in the Java Sea, even though the area of these waters only covers 7% of the total area of national waters. Fisheries productivity is related to the net primary productivity value resulting from the activity of phytoplankton or chlorophyll-a. Net primary productivity (NPP) is influenced by the presence of nutrients, light, chlorophyll-a, Photosynthetically Available Radiation (PAR) and sea surface temperature (SST). The purpose of this research is to analyze the distribution value of net primary productivity in the Java Sea by utilizing Aqua-MODIS satellite imagery using the Vertically Generalized Production Model (VGPM) method with a range of 2017-2021. The results showed that the waters of the Java Sea have quite high fertility and are classified as Eutrophic because the general monthly average from 2017-2021 has an NPP value of >750 mgC/m2/day. The value of primary productivity follows the seasonal pattern, will be high in the east moonson season and decrease in the west monsoon season. Laut Jawa merupakan wilayah dengan laju eksploitasi sumberdaya perikanan tertinggi di Indonesia. Sebanyak 32% dari total produksi perikanan nasional atau sebesar 2,2 juta ton berasal dari hasil tangkapan di Laut Jawa meskipun luas wilayah perairan ini hanya mencakup 7% dari total luas wilayah perairan nasional. Produktivitas perikanan tangkap berhubungan dengan nilai produktivitas primer bersih hasil dari aktivitas fitoplankton atau klorofil-a. Produktivitas primer bersih di suatu perairan dipengaruhi oleh adanya unsur hara, cahaya, klorofil-a, Photosynthetically Available Radiation (PAR) dan suhu permukaan laut (SPL). Tujuan dari penelitian ini adalah untuk menganalisis nilai distribusi produktivitas primer bersih di Laut Jawa dengan memanfaatkan citra satelit Aqua-MODIS menggunakan metode Vertically Generalized Production Model (VGPM) dengan rentang tahun 2017-2021. Hasil penelitian menunjukkan bahwa perairan Laut Jawa memiliki kesuburan yang cukup tinggi dan tergolong Eutrofik karena rata-rata bulanan secara umum mulai dari tahun 2017-2021 memiliki nilai NPP >750 mgC/m2/hari. Nilai produktivitas primer mengikuti pola musim, akan tinggi pada musim timur (kemarau) dan menurun pada musim barat (penghujan).
Kelimpahan dan Karakteristik Mikroplastik di Perairan Kolam Labuh dan Sungai Blangor Kecamatan Palang, Tuban
Authors: Sidiqi Fawaz Muhammad , Yulianto Bambang , Suprijanto Jusup 
Published: October 2023

Microplastic contamination has been identified in Indonesian water bodies, raising environmental concerns. This study investigates microplastic abundance and characteristics in water and sediment of Palang Waters (Kolam Labuh and Sungai Blangor) in Tuban. Seawater and river samples were collected using a 75 µm mesh plankton net. Microplastics were quantified under microscopy, and polymer analysis utilized Fourier Transform Infrared (FT-IR) spectroscopy. Seawater showed an abundance of 40,000 ± 11,357.82 particles/m3, with 48.75% fragments, 44.58% fibers, and 6.67% granules. River microplastic abundance was 13,333.33 ± 5,033.23 particles/m3, comprising 82.5% fibers, 10% fragments, and 7.5% granules. Sediment's average microplastic abundance was 226.67 ± 83.27 particles/m3, including 53% fibers, 29% fragments, and 18% granules. Statistical analysis highlighted significant differences in microplastic abundance among seawater, river water, and sediment (P-Value = 0.001). Notable differences existed between seawater and river water (P-value = 0.009), and seawater and sediment (P-value 0.001), but not between river water and sediment (P-value = 0.143). Polymer analysis revealed polymers such as Polyvinyl Chloride (PVC), Polyethylene (PE), and High-Density Polyethylene (HDPE). This research offers insights into microplastic presence, aiding in understanding aquatic pollution. Kontaminasi mikroplastik telah terjadi di beberapa perairan Indonesia. Mikroplastik memiliki ukuran ≤5 mm. Penelitian ini bertujuan untuk mengetahui kelimpahan dan karakteristik mikroplastik pada air dan sedimen di Perairan Kolam Labuh dan Sungai Blangor, Kecamatan Palang, Tuban. Sampel air laut dan sungai diambil menggunakan plankton net dengan ukuran mesh 75 µm. Kelimpahan dan bentuk mikroplastik dihitung dan diamati menggunakan mikroskop, dan analisis polimer menggunakan uji Fourier Transform Infrared (FT-IR). Hasil penelitian menunjukkan bahwa kelimpahan mikroplastik pada air laut sebanyak 40.000 ± 11.357,82 partikel/m3, bentuk fragmen sebanyak 48,75 %, kemudian fiber sebanyak 44,58 % dan granules sebanyak 6,67% pada air laut. Sedangkan di Sungai didapatkan kelimpahan mikroplastik sebanyak 13.333,33 ± 5.033,23 partikel/m3, bentuk fiber sebanyak 82,5 %,fragmen 10 % dan fiber 7,5 %. Kelimpahan rata-rata mikroplastik pada sedimen ialah 226,67 ± 83,27 , bentuk fiber sebanyak 53%, fragmen 29% dan granules 18%. Hasil penelitian juga menunjukkan adanya perbedaan kelimpahan mikroplastik pada air laut, sungai dan sedimen (P-Value = 0,001). Perbedaan kelimpahan mikroplastik terjadi antara air laut dengan air sungai (P-value = 0,009) dan antara air laut dengan sedimen (P-value 0,001), sedangkan antara air sungai dan sedimen tidak terjadi perbedaan (P-value = 0,143). Hasil analisis polimer menunjukkan jenis polimer yang ditemukan meliputi Polivinil Klorida (PVC), Polyethylene (PE) dan High-Density Polyethylene (HDPE).
Psych verbs: the behavior of ObjExp verbs in Brazilian Portuguese
Authors: Cançado Márcia , Amaral Luana , Meirelles Letícia , Foltran Maria José 
Published: October 2023

AbstractPsychological verbs, especially Object Experiencer verbs, are widely discussed in the linguistic literature because of their peculiar syntactic and semantic properties. Two main issues regarding Object-Experiencer verbs are often raised: their aspectual nature and an alternation process (with the experiencer in subject position). This article analyzes Brazilian Portuguese Object Experiencer verbs, focusing on these issues. Based on a study of 170 verbs, we claim that Object Experiencer verbs constitute a verb class whose members describe a complex stage-level state in which a stimulus state activates (in a causative relation) a mental state in an experiencer. In addition, we argue that Object-Experiencer verbs appear in an inverse form: the experiencer as subject, and the stimulus as oblique. We claim that such an inverse form does not result from the causative alternation. In the inverse structure, different from an inchoative form of a change-of-state verb, both arguments are strongly preferable, and the verbs still denote a stative situation. We also provide a representation for the event structure of those verbs, using predicate decomposition, that is associated with their syntactic properties.
Venezuela: mais uma evidência que o capitalismo deu errado
Authors: Damasceno Fernando , Coelho Wanderson de Oliveira 
Published: October 2023

Resumo
Este artigo traz reflexões sobre o regime econômico característico da Venezuela, comumente, definido como sendo socialista. O objetivo é desconstruir tal equívoco teórico e prático, demonstrando o nacionalismo burguês característico do movimento bolivariano liderado por Chávez e, agora, pelo seu sucessor, Maduro. Para tanto, traçou-se paralelo entre as medidas socializantes adotadas na Revolução Russa, sobretudo, a planificação da economia, e o governo chavista. Como demonstrar-se-á, tal governo sequer teve a intenção de implementar o socialismo ou qualquer medida socializante. Para subsidiar esta discussão, utilizamos pesquisas bibliográficas de pesquisadores especialistas na temática, sendo o materialismo histórico aporte metodológico que se inscreve desde as entrelinhas.
Palavras-chave: Venezuela. Chavismo. Nacionalismo burguês.
CHARTING THE PATH: OVERCOMING HURDLES AND FORGING AHEAD WITH THE SINGLE NATIONAL CURRICULUM IN PAKISTAN'S PRIMARY SCHOOLS
Authors: Thakur Ibtasam , Aziz Fakhra , Sultana Naveed , Haqdad Ambreen 
Published: October 2023

Purpose of the study: The purpose of this research is to quantify the challenges and way forward in the implementation of a single national curriculum (SNC) in primary public schools in Pakistan.
Methodology: The study is conducted through a questionnaire consisting of forty-nine questions related to challenges in SNC implementation in primary public schools. The collected data was analysed using regression, correlation, and descriptive statistical techniques.
Main Findings: This study investigated the impact of the challenges like class inequality, gender difference, the role of media, the role of Parents and society, student’s interest, and their financial background that affect the implementation of SNC in the primary public school of Pakistan to understand the better teachers’ perspectives. To ensure that educational institutions continue to meet the demands of society, families, legislators, and educators all must collaborate toward the common objective of resolving these challenges.
Applications of the study: The insights derived from this study, have far-reaching implications for policymakers, educators, and stakeholders in the Pakistani education system. They can utilize the study's recommendations and best practices to refine the implementation of the Single National Curriculum, thereby enhancing the quality of primary education. This research provides a practical roadmap for addressing the challenges identified, and fostering a more effective and inclusive educational environment. It serves as a valuable resource for shaping future policies and practices in Pakistan's primary school system, ultimately benefiting students and the broader society. At a primary public school of Pakistan, the implementation of SNC has been delayed due to class inequality, gender imbalance, the engagement of the media, the role of parents and society, and financial situation of the students.
Novelty/Originality of the study: The uniqueness of this study, "Charting the Path: Overcoming Hurdles and Forging Ahead with the Single National Curriculum in Pakistan's Primary Schools," is rooted in its exploration of the complex implementation process of a nationwide curriculum reform in Pakistan's primary education. It offers a comprehensive examination of the challenges faced and the strategies employed, shedding light on a topic relatively unexplored in the educational research landscape, making it a pioneering work in the field.
Políticas educacionais para o enfrentamento do analfabetismo de jovens e adultos no extremo norte do Bico do Papagaio - Tocantins: o caso do município de Augustinópolis
Authors: Mariano Carvalho Silva Walisson , Silva Evangelista Freire Juciley 
Published: October 2023

Esta pesquisa analisa as políticas educacionais desenvolvidas por parte do governo municipal de Augustinópolis para a efetivação parcial da meta 9, do Plano Municipal de Educação (PME - 2015-2025), que trata sobre o analfabetismo de jovens e adultos. Os relatórios de monitoramento e avaliação do PME (2015-2025) foram analisados junto com a comparação entre os dados absolutos de analfabetos do Censo de 2010, e a quantidade de matrícula no primeiro segmento da educação de jovens e adultos (EJA), disponibilizados pelo Censo Escolar dos anos de 2011 a 2021, do município pesquisado. Os resultados demonstram os limites e ausências do governo municipal com as políticas de educação de jovens e adultos.
Palavras-chave: políticas educacionais, analfabetismo, educação de jovens e adultos.

Educational policies to face youth and adults illiteracy in the extreme north of Bico do Papagaio – Tocantins: the case of municipality of Augustinópolis
ABSTRACT. This research analyzes the educational policies developed by the municipality government of Augustinópolis for the partial implementation of mark 9, of the Municipal Education Plan (PME- 2015-2025) which deals with illiteracy among young people and adults. The monitoring and evaluation reports of the PME (2015-2025) were analyzed, together with the comparison between the absolute data of illiterates from the 2010 Census, and the number of enrollments in the first segment of youth and adult education (EJA), made available by the School Census for the years 2011 to 2021, of the researched municipality. The results demonstrate the limits and absences of the municipal government with youth and adult education policies.
Keywords: educational policies, illiteracy, education youth and adults.

Políticas educativas para enfrentar el analfabetismo entre jóvenes y adultos en el extremo norte de Bico do Papagaio - Tocantins: el caso del municipio de Augustinópolis
RESUMEN. Esta investigación analiza las políticas educativas desarrolladas por el gobierno municipal de Augustinópolis para la implementación parcial de la meta 9, del Plan Municipal de Educación (PME - 2015-2025) que trata el analfabetismo entre jóvenes y adultos. Se analizaron los informes de seguimiento y evaluación del PME (2015-2025), así como la comparación entre los datos absolutos de analfabetos del Censo de 2010, y el número de matrículas en el primer segmento de educación de jóvenes y adultos (EJA), disponibles por el Censo Escolar de 2011 a 2021. Los resultados demuestran los límites y las ausencias del gobierno municipal con las políticas de educación de jóvenes y adultos.
Palabras clave: políticas educativas, analfabetismo, educación de jóvenes y adultos.