bluuebunny/crossref_metadata_2025_split huggingface dataset:
Findings from the Longitudinal CINRG Becker Natural History Study
Authors: Clemens Paula R. , Gordish-Dressman Heather , Niizawa Gabriela , Gorni Ksenija , Guglieri Michela , Connolly Anne M. , Wicklund Matthew , Bertorini Tulio , Mah Jean , Thangarajh Mathula , Smith Edward C. , Kuntz Nancy L. , McDonald Craig M. , Henricson Erik , Upadhyayula S , Byrne Barry , Manousakis Georgios , Harper Amy , Iannaccone Susan , Dang Utkarsh J. 
Published: November 2023

Background: Becker muscular dystrophy is an X-linked, genetic disorder causing progressive degeneration of skeletal and cardiac muscle, with a widely variable phenotype. Objective: A 3-year, longitudinal, prospective dataset contributed by patients with confirmed Becker muscular dystrophy was analyzed to characterize the natural history of this disorder. A better understanding of the natural history is crucial to rigorous therapeutic trials. Methods: A cohort of 83 patients with Becker muscular dystrophy (5–75 years at baseline) were followed for up to 3 years with annual assessments. Muscle and pulmonary function outcomes were analyzed herein. Age-stratified statistical analysis and modeling were conducted to analyze cross-sectional data, time-to-event data, and longitudinal data to characterize these clinical outcomes. Results: Deletion mutations of dystrophin exons 45–47 or 45–48 were most common. Subgroup analysis showed greater pairwise association between motor outcomes at baseline than association between these outcomes and age. Stronger correlations between outcomes for adults than for those under 18 years were also observed. Using cross-sectional binning analysis, a ceiling effect was seen for North Star Ambulatory Assessment but not for other functional outcomes. Longitudinal analysis showed a decline in percentage predicted forced vital capacity over the life span. There was relative stability or improved median function for motor functional outcomes through childhood and adolescence and decreasing function with age thereafter. Conclusions: There is variable progression of outcomes resulting in significant heterogeneity of the clinical phenotype of Becker muscular dystrophy. Disease progression is largely manifest in adulthood. There are implications for clinical trial design revealed by this longitudinal analysis of a Becker natural history dataset.
Targeted neurorehabilitation strategies in post-stroke aphasia
Authors: Shah-Basak Priyanka , Boukrina Olga , Li Xin Ran , Jebahi Fatima , Kielar Aneta 
Published: November 2023

Background: Aphasia is a debilitating language impairment, affecting millions of people worldwide. About 40% of stroke survivors develop chronic aphasia, resulting in life-long disability. Objective: This review examines extrinsic and intrinsic neuromodulation techniques, aimed at enhancing the effects of speech and language therapies in stroke survivors with aphasia. Methods: We discuss the available evidence supporting the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation, and functional MRI (fMRI) real-time neurofeedback in aphasia rehabilitation. Results: This review systematically evaluates studies focusing on efficacy and implementation of specialized methods for post-treatment outcome optimization and transfer to functional skills. It considers stimulation target determination and various targeting approaches. The translation of neuromodulation interventions to clinical practice is explored, emphasizing generalization and functional communication. The review also covers real-time fMRI neurofeedback, discussing current evidence for efficacy and essential implementation parameters. Finally, we address future directions for neuromodulation research in aphasia. Conclusions: This comprehensive review aims to serve as a resource for a broad audience of researchers and clinicians interested in incorporating neuromodulation for advancing aphasia care.
Didactic potential of educational VR films (on the example of the film “Electric power industry of Russia”)
Authors: Karakozov S. D. , Fedorova Yu. V. , Tokhtueva S. Yu. , Tralkova N. B. 
Published: November 2023

The introduction of modern video technologies into pedagogical practice is one of the ways to increase students’ motivation to learn about the world. The article describes in detail the advantages, methodological purpose, and didactic potential of educational VR films on the example of the film in 360° format “Electric power industry of Russia”, created by a team of employees of The Academy of Public Policy Implementation and Professional Development of Educators of the Ministry of Education of the Russian Federation (The Academy of Ministry of Education of the Russian Federation) for free use in Russian educational organizations.The methodology of the study of educational VR films didactic potential presented in the article is based on the activity approach to learning, the principles of systematicity, and interdisciplinarity. The activity approach in the use of VR film is provided by the maximum effect of presence, which is experienced by the viewer, and independence in the choice of the subject of attention. The work of an active and proactive student is complemented by the activity of a teacher who can guide the student and choose objects from an educational VR film to set learning objectives, and formulate questions and tasks. The principles of systematicity and interdisciplinarity are provided by educational content created on the basis of the integration of knowledge from different subject areas, which allows teachers to use the didactic potential of the VR film in different disciplines and age groups.The proposed methodological solutions for the use of VR film are of practical value for the educational process in a modern school: they contribute to the formation of a holistic view of students about the achievements of Russian science and modern professions (in particular, in the electric power industry), the education of patriotism and pride in the Fatherland, the development of skills of independence and self-control in learning activities.The authors see the development of the project as one of the strategic directions in the field of digital transformation of education, aimed at improving the quality of education of modern schoolchildren.
Analisis Tingkat Kepuasaan Pengguna Aplikasi Mobile Traveloka Menggunakan Metode End-User Computing Satisfaction (EUCS)
Authors: Muhammad Mumtaz  , Rudy Sanjaya  
Published: November 2023

Aplikasi mobile Traveloka adalah layanan yang menawarkan akomodasi dan produk perjalanan, yang disediakan oleh PT Trinusa Travelindo. penelitian ini bertujuan untuk mengetahui seberapa puas pengguna dengan aplikasi mobile Traveloka. Penelitian menggunakan metodologi EUCS, yang menggabungkan kriteria seperti konten, akurasi, bentuk, kemudahan penggunan, dan ketepatan waktu sebagai komponen fundamental dari penilaian. Pengumpulan data dilakukan menggunakan kuesioner yang didistribusikan di antara pengguna mobile traveloka. Setelah penilaian menyeluruh dari validitas dan reliabelitas, temuan tes mengkonfirmasi validitas dan keandalan pertanyaan. Rata-rata kepuasan Kaplan dan Norton dan kategori digunakan untuk menghitung data output kuesioner. Survei melibatkan 300 peserta yang skor lima faktor, termasuk Akurasi, Konten, bentuk, ketepatan waktu, dan Kemudahan Penggunaan dinilai dalam angka 3,78 yang masuk dalam kategori puas. Oleh karena itu, pengembang disarankan untuk terus mempertahankan dan meningkatkan kualitas aplikasi mobile Traveloka
Study of the Effect of Matrix-forming Polymers on the Release Rate of Sodium 4,4'-(propanediamido)dibenzoate from Tablets
Authors: Kotsur Yu. M. , Flisyuk E. V. , Sidorov K. O. , Titovich I. A. , Narkevich I. A. 
Published: November 2023

Introduction. Wet granulation technology is a process of directed particle aggregation of powder materials to obtain required properties of tablet masses and, as a consequence, to achieve satisfactory characteristics of tablets. In this addition, as a result of wet granulation technology, if special excipients are used, it becomes possible to control the rate and kinetics of release of active pharmaceutical substances from tablets to achieve the desired therapeutic effect.Aim. To study the effect of matrix-forming components included in the composition of mixtures for granulation on the rate of release of sodium 4,4'-(propanediamido)dibenzoate from tablets.Materials and methods. The original substance sodium 4,4'-(propanediamido)dibenzoate, as well as a number of excipients, which included polymers used for prolonged-release dosage forms, lubricant – sodium stearyl fumarate, as well as pore-forming agents – PVP and MCC, were the objects of the study. The key parameters of tablets and dissolution kinetics were studied in accordance with the requirements of State Pharmacopoeia of the Russian Federation XIV edition and Pharmacopeia of the Eurasian Economic Union.Result and discussion. Prolonged release was achieved for all tablets, but more than 90 % of the substance was released after 12 hours in tablets containing ethylcellulose as a matrix-forming polymer. The release of APS from tablets of this formulation was the most prolonged.Сonclusion. The effect of matrix-forming components included in the composition of mixtures for granulation on the rate of release of 4,4'-(propanediamido)sodium dibenzoate from tablets has been studied. The most uniform and complete release of ASF from tablets in which the matrix-forming polymer is ethylcellulose in the amount of 27.7 %.
The Role of the Geometric Configuration of Diethylaminoethanol Derivative in the Pharmaceutical Development of a Dosage Form Based on It
Authors: Kotsur Yu. M. , Tserkovnaya K. M. , Flisyuk E. V. , Titovich I. A. , Sidorov K. O. , Narkevich I. A. 
Published: November 2023

Introduction. A comprehensive study of the active pharmaceutical ingredient (API) molecule is one of the defining criteria for pharmaceutical development according to the Quality by Design (QbD) concept and the ICH Q8 framework. The spatial arrangement of atoms in the molecule often has a significant impact on the physicochemical and technological properties of API, and hence on the method of producing dosage form based on it.Aim. To study some properties of substances, geometrical isomers of the molecule, which is a derivative of diethylaminoethanol (DEAE), as well as to compare the selected technologies for the preparation of dosage form.Materials and methods. The objects of the study were two substances, spatial isomers of the molecule, a derivative of DEAE, possessing neuroprotective, antiastenic and antioxidant effects. The study of properties of API and the obtained tablets was carried out in accordance with the requirements of the State Pharmacopoeia of the Russian Federation XIV edition, the Pharmacopoeia of the Eurasian Economic Union, as well as the European Pharmacopoeia 9.0 edition. In this research were used substances that have not expired at the time of the study, as well as authorized for medical use.Results and discussion. The geometrical configuration of the DEAE derivative influences the properties of the API, which has an impact on the stages of pharmaceutical development, especially on the development of the technology and formulation of dosage form. The use of cis-DEAE significantly simplifies the technological process and improves the quality of the resulting drug, and as a consequence, better stability and longer shelf life of dosage form may be achieved.Conclusion. In the course of the study, some properties of cis-DEAE API were studied and compared with similar properties of trans-DEAE. A comparison of tablet preparation technologies based on the two mentioned configurations of the DEAE derivative molecule has been carried out. It was found that the isomers have different technological properties and also differ significantly in moisture adsorption capacity. This property determines the approach to tablet preparation. The technology of tablets based on cis-DEAE appears to be simpler, and dosage form based on it is more stable.
TINGKAT KEPUASAN PASIEN RAWAT JALAN DI INSTALASI RADIOLOGI RSUD. M. ZEIN PAINAN
Authors: Mareta Santa , Pertama Tari Putri 
Published: November 2023

Kepuasan pasien adalah suatu tingkat perasaan pasien yang timbul sebagai akibat dari kinerja layanan kesehatan yang diperoleh setelah pasien membandingkan dengan apa yang diharapkannya. Di RSUD. M. Zein Painan terjadinya penurunan jumlah kunjungan pasien rawat jalan pada bulan Agustus sampai Oktober 2020. Pada bulan Agustus kunjungan pasien sebanyak 331 orang, September 2020 sebanyak 291 orang dan bulan Oktober 2020 sebanyak 260 orang, serta peneliti telah mewawancarai 10 pasien rawat jalan yang datang ke Instalasi Radiologi yang menyatakan bahwa pasien 8 orang pasien menyatakan bahwa kurang nyaman terhadap lingkungan di Instalasi Radiologi RSUD M. Zein Painan seperti ruang tunggu yang kurang bersih dan banyaknya petugas lain atau pasien lain yang lewat disana. Penelitian ini bertujuan untuk mengetahui persentase tingkat kepuasan pasien berdasarkan standar Kemenkes Nomor: 129/Menkes/SK/II/2008 di instalasi radiologi RSUD M. Zein Painan. Penelitian ini menggunakan metode kuantitatif. Teknik sampel menggunakan metode Accidental Sampling pada 87 pasien rawat jalan pengumpulan data menggunakan kuesioner dan pengolahan data dilakukan dengan sistem komputerisasi dan dianalisis dengan analisa univariat. Hasil penelitian menunjukkan 79,2% responden merasa puas dengan pelayanan instalasi radiologi RSUD M. Zein Painan. Dari hasil penelitian dapat disimpulkan bahwa tingkat kepuasan pasien di instalasi radiologi RSUD M. Zein Painan belum memenuhi SK Menteri Kesehatan Republik Indonesia Nomor: 129/Menkes/SK/II/2008 tentang Standar Pelayanan radiologi menyatakan Standar Kepuasan Pelanggan ≥80%.
Exploring global research status and trends in anti-obesity effects of traditional Chinese medicine through intestinal microbiota: a bibliometric study
Authors: Huang Wenjing , Wang Jiuyuan , Kuang Min , Xiao Zixuan , Fan Boyan , Sun Guixiang , Tan Zhoujin 
Published: November 2023

BackgroundThe intestinal microbiota (IM) has been found to contribute to metabolic disorders that lead to excessive fat accumulation, systemic and chronic low-grade inflammation, and insulin resistance in the host. Current research highlights a pivotal interaction between IM and traditional Chinese medicine (TCM) in mitigating obesity-related diseases. Undeniably, IM stands as a central focus in TCM research aimed at preventing and treating obesity. Therefore, tracing the progress and trends in this field can offer valuable references and insights for future studies.MethodsOn June 17, 2023, we conducted a literature search on the topic of “IM and obesity in TCM” spanning the period from 2009 to 2023. We extracted the primary information of the publications, which includes complete records and reference citations, from the Science Citation Index Expanded (SCI-E) within the Web of Science Core Collection (WoSCC). To visualize and analyze the literature, we utilized CiteSpace and VOSviewer for bibliometric analysis.ResultsDuring the past fifteen years, a rapid increase in the number of publications has been observed. The cooperative networks demonstrate China, Beijing University of Chinese Medicine, and Food &amp; Function as the most active countries, organizations, and journals in this field, respectively. Liu Bin has contributed the most publications. A paper by Xu Jia, published in 2014, holds the highest Local Citation Score (LCS). Analyses of keyword co-occurrence and reference co-citation indicate that the research hotspots of IM and obesity in TCM are primarily focused on the metabolic benefits driven by endogenous functional metabolic molecules generated by TCM regulation of IM. Other focal points include the mechanism by which TCM regulates IM to restore the intestinal mucosal barrier This is a provisional file, not the final typeset article, and manages the gut-organ axis, the metabolic advantages of acupuncture’s regulation of IM, and the process by which Chinese medicine small molecules transform IM.ConclusionThis research offers a comprehensive understanding of the current status, hotspots, and trends in global TCM research. Additionally, it provides a comprehensive summary and exploration of the latest advancements in this field, thereby emphasizing the essence of TCM more effectively.
Association between serum polyunsaturated fatty acids and bone mineral density in US adults: NHANES 2011-2014
Authors: Liang Hao , Xiong Chuang , Luo Yuangang , Zhang Jun , Huang Yanran , Zhao Runhan , Zhou Nian , Zhao Zenghui , Luo Xiaoji 
Published: November 2023

ObjectiveThe purpose of this study was to investigate the association between serum polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).MethodsWe performed a cross-sectional study based on data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. The weighted multiple linear regression model was utilized to determine the association between serum PUFAs and BMD. Further smoothed curve fitting and threshold effect analysis were conducted. Finally, we performed a subgroup analysis.ResultsIn total, 1979 participants aged 20-59 years were enrolled. After adjusting for all covariates, we found that serum docosapentaenoic acid (DPA) was positively associated with head BMD (β = 0.0015, 95% Cl: 0.0004, 0.0026, P = 0.008296) and lumbar spine BMD (β = 0.0005, 95% Cl: 0.0000, 0.0010, P = 0.036093), and serum eicosadienoic acid (EDA) was negatively associated with thoracic spine BMD (β = -0.0008, 95% Cl: -0.0016, -0.0000, P = 0.045355). Smoothed curve fitting revealed a nonlinear positive association between serum DPA and lumbar spine BMD. Threshold effect analysis indicated that the threshold of serum DPA was 81.4 µmol/L. Subgroup analysis revealed a positive correlation between serum DPA and head BMD in the subgroup aged 50-59 years (β = 0.0025, 95% Cl: 0.0002, 0.0049, P = 0.035249) and females (β = 0.0026, 95% Cl: 0.0008, 0.0044, P = 0.005005). There was a positive relationship between serum DPA and lumbar spine BMD in females (β = 0.0008, 95% Cl: 0.0001, 0.0015, P = 0.017900) and a negative association between serum EDA and thoracic spine BMD in the subgroup aged 30-39 years (β = -0.0016, 95% Cl: -0.0031, -0.0001, P = 0.041331), males (β = -0.0012, 95% Cl: -0.0023, -0.0001, P = 0.039364) and other races (β = -0.0021, 95% Cl: -0.0037, -0.0006, P = 0.008059).ConclusionThis study demonstrated a linear positive relationship between serum DPA and head BMD, a nonlinear positive association between serum DPA and lumbar spine BMD, and a linear negative correlation between serum EDA and thoracic spine BMD in US adults.
Common gastrointestinal diseases and chronic obstructive pulmonary disease risk: a bidirectional Mendelian randomization analysis
Authors: Shen Zixiong , Qiu Binxu , Chen Lanlan , Zhang Yiyuan 
Published: November 2023

Background: Observational studies suggest an association between gastrointestinal diseases and chronic obstructive pulmonary disease (COPD), but the causal relationship remains unclear.Methods: We conducted bidirectional Mendelian randomization (MR) analysis using summary data from genome-wide association study (GWAS) to explore the causal relationship between common gastrointestinal diseases and COPD. Gastrointestinal diseases included gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), irritable bowel syndrome (IBS), Crohn’s disease (CD), ulcerative colitis (UC), functional dyspepsia (FD), non-infectious gastroenteritis (NGE), and constipation (CP). Significant MR analysis results were replicated in the COPD validation cohort.Results: Bidirectional MR analysis supported a bidirectional causal relationship between GERD and COPD, and COPD was also found to increase the risk of IBS and CP. Our study also provided evidence for a bidirectional causal relationship between PUD and COPD, although the strength of evidence may be insufficient. Furthermore, we provided evidence that there is no causal association between CD, UC, FD, NGE, and COPD.Conclusion: This study offers some evidence to clarify the causal relationship between common gastrointestinal diseases and COPD. Further research is needed to understand the underlying mechanisms of these associations.
Hormonal contraception and risk for cognitive impairment or Alzheimer's disease and related dementias in young women: a scoping review of the evidence
Authors: Gregory Sarah , Booi Laura , Jenkins Natalie , Bridgeman Katie , Muniz-Terrera Graciela , Farina Francesca R. 
Published: November 2023

IntroductionWomen are significantly more likely to develop Alzheimer's disease and related dementias (ADRD) than men. Suggestions to explain the sex differences in dementia incidence have included the influence of sex hormones with little attention paid to date as to the effect of hormonal contraception on brain health. The aim of this scoping review is to evaluate the current evidence base for associations between hormonal contraceptive use by women and non-binary people in early adulthood and brain health outcomes.MethodsA literature search was conducted using EMBASE, Medline and Google Scholar, using the keywords “hormonal contraception” OR “contraception” OR “contraceptive” AND “Alzheimer*” OR “Brain Health” OR “Dementia”.ResultsEleven papers were identified for inclusion in the narrative synthesis. Studies recruited participants from the UK, USA, China, South Korea and Indonesia. Studies included data from women who were post-menopausal with retrospective data collection, with only one study contemporaneously collecting data from participants during the period of hormonal contraceptive use. Studies reported associations between hormonal contraceptive use and a lower risk of ADRD, particularly Alzheimer's disease (AD), better cognition and larger grey matter volume. Some studies reported stronger associations with longer duration of hormonal contraceptive use, however, results were inconsistent. Four studies reported no significant associations between hormonal contraceptive use and measures of brain health, including brain age on MRI scans and risk of AD diagnosis.DiscussionFurther research is needed on young adults taking hormonal contraceptives, on different types of hormonal contraceptives (other than oral) and to explore intersections between sex, gender, race and ethnicity.Systematic Review Registrationhttps://doi.org/10.17605/OSF.IO/MVX63, identifier: OSF.io: 10.17605/OSF.IO/MVX63