bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-cultural adaptation and psychometric properties of the Chinese version of the Orthorexia Nervosa Inventory
Authors: Sun Xinzhang , Lu Ying , Jian Chengping , Zhang Hanqing 
Published: January 2025

BackgroundOrthorexia nervosa refers to an unhealthy preoccupation with maintaining a perfect diet, which is marked by highly restrictive eating habits, rigid food rituals, and the avoidance of foods perceived as unhealthy or impure. In recent years, the Orthorexia Nervosa Inventory (ONI) has gained recognition as a promising tool for assessing orthorexia tendencies and behaviors, addressing the limitations of existing ON-specific measures. This study aimed to evaluate the psychometric properties of the Chinese version of the ONI.MethodsA total of 717 participants (Mage = 20.11 years, 78.66% female) completed the Orthorexia Nervosa Inventory (ONI) alongside the Chinese version of the Düsseldorf Orthorexia Scale (C-DOS). The ONI was translated into Chinese using the Brislin traditional translation model, following formal authorization from the original author. This translation process included literal translation, back translation, and cultural adaptation to ensure both linguistic and contextual fidelity. Item analysis was employed to assess item differentiation. Scale reliability was determined by measuring internal consistency. Furthermore, exploratory and confirmatory factor analyses were conducted to investigate and confirm the underlying factor structure and overall validity of the scale.ResultsThe Chinese version of the Orthorexia Nervosa Inventory (ONI) consists of 24 items across three dimensions. The overall Cronbach’s alpha coefficient for the scale was 0.956, indicating excellent internal consistency. The Cronbach’s alpha coefficients for the individual dimensions were 0.894, 0.933, and 0.848, respectively, demonstrating high reliability for each dimension. Additionally, McDonald’s ω was 0.957 for the entire scale, reflecting strong stability in internal consistency, with individual dimensions having McDonald’s ω coefficients of 0.895, 0.934, and 0.854. The Spearman-Brown split-half reliability coefficient was 0.931, and McDonald’s ω for the split-half reliability was also 0.931, indicating excellent consistency across the scale’s two halves. The test–retest reliability was 0.987, with a 95% confidence interval ranging from 0.978 to 0.993, suggesting excellent stability over time and strong consistency across different measurement points. All model fit indices fell within acceptable ranges, affirming the structural validity of the Chinese version. The results from both exploratory and confirmatory factor analyses further supported this conclusion.ConclusionThis study successfully translated and culturally adapted the ONI into Chinese, followed by a comprehensive evaluation of its psychometric properties. The findings demonstrate that the Chinese version of the ONI possesses strong reliability and validity. In the context of varying cultural backgrounds and dietary habits, this scale serves as a valid tool for assessing and screening the Chinese ON population.
Navigating next-gen nutrition care using artificial intelligence-assisted dietary assessment tools—a scoping review of potential applications
Authors: Phalle Anuja , Gokhale Devaki 
Published: January 2025

IntroductionRecent developments in Artificial Intelligence (AI) and Machine Learning (ML) technologies have opened new avenues for their applications in dietary assessments. Conventional dietary assessment methods are time-consuming, labor-driven, and have high recall bias. AI-assisted tools can be user-friendly and provide accurate dietary data. Hence, this review aimed to explore the applications of AI-assisted dietary assessment tools in real-world settings that could potentially enhance Next-Gen nutrition care delivery.Materials and methodsA total of 17,613 original, full-text articles using keywords such as “artificial intelligence OR food image analysis OR wearable devices AND dietary OR nutritional assessment,” published in English between January 2014 and September 2024 were extracted from Scopus, Web of Science, and PubMed databases. All studies exploring applications of AI-assisted dietary assessment tools with human participation were included; While methodological/developmental research and studies without human participants were excluded as this review specifically aimed to explore their applications in real-world scenarios for clinical purposes. In the final phase of screening, 66 articles were reviewed that matched our inclusion criteria and the review followed PRISMA-ScR reporting guidelines.ResultsWe observed that existing AI-assisted dietary assessment tools are integrated with mobile/web-based applications to provide a user-friendly interface. These tools can broadly be categorized as “Image-based” and “Motion sensor-based.” Image-based tools allow food recognition, classification, food volume/weight, and nutrient estimation whereas, Motion sensor-based tools help capture eating occasions through wrist movement, eating sounds, jaw motion &amp; swallowing. These functionalities capture the dietary data regarding the type of food or beverage consumed, calorie intake, portion sizes, frequency of eating, and shared eating occasions as real-time data making it more accurate as against conventional dietary assessment methods. Dietary assessment tools integrated with AI and ML could estimate real-time energy and macronutrient intake in patients with chronic conditions such as obesity, diabetes, and dementia. Additionally, these tools are non-laborious, time-efficient, user-friendly, and provide fairly accurate data free from recall/reporting bias enabling clinicians to offer personalized nutrition.ConclusionTherefore, integrating AI-based dietary assessment tools will help improve the quality of nutrition care and navigate next-gen nutrition care practices. More studies are required further to evaluate the efficacy and accuracy of these tools.
Prognostic role of prognostic nutritional index in patients with bladder cancer: a systematic review and meta-analysis
Authors: Sun Jing , Li Zhenzhen , Zhu Xiaming 
Published: January 2025

AimsAn increasing number of studies have explored the prognostic significance of the prognostic nutritional index (PNI) in bladder cancer patients, but the results are inconsistent. This study systematically investigates the prognostic value of baseline PNI in patients with bladder cancer through a meta-analytic approach.MethodsThe databases of PubMed, EmBase, and the Cochrane library were systematically searched for eligible studies from inception until April 2024. The prognostic outcomes including overall survival (OS) and recurrence-free survival (RFS). The summary outcomes were calculated using the random-effects model, and the exploratory analyses were performed by sensitivity and subgroup analyses.ResultsTwelve retrospective studies involved 2,951 patients with bladder cancer were selected in final analysis. The summary results found low PNI were associated with poor OS (HR: 1.80; 95%CI: 1.54-2.10; P&lt;0.001) and RFS (HR: 1.53; 95%CI: 1.15-2.04; P=0.003). The association between low PNI and shorter OS was statistically significant in all subgroups. Additionally, the association between low PNI and RFS was also significant in most subgroups.ConclusionsThis study found a significant association between low PNI and poor prognosis in bladder cancer patients. Further large-scale prospective study should be performed to verify this association, and assess the nutrition interventions for patients with bladder cancer.Systematic review registrationhttps://inplasy.com/inplasy-2024-8-0020/, identifier INPLASY202480020.
HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors
Authors: Xi Xiaoyu , Zhang Xiaona , Tang Jianxin , Fan Xiumei , Du Jiexian 
Published: January 2025

IntroductionEndometrial Carcinoma (UCEC) is a prevalent malignant tumor within the female reproductive system. HLA-DMB, the beta chain of the non-classical MHC class II protein HLA-DM, has been implicated in the progression of various cancers. However, its role in the development of endometrial carcinoma remains unclear. Therefore, we conducted a preliminary exploration of the prognostic value and potential mechanisms of HLA-DMB in uterine corpus endometrial carcinoma (UCEC).MethodsThe differential expression of HLA-DMB was analyzed in 554 tumor samples and 35 normal samples obtained from the TCGA database. The differential expression of HLA-DMB across various cancers, along with immune infiltration analysis, was conducted using the TIMER2.0 database. Additionally, the expression of HLA-DMB in endometrial carcinoma was examined in the GEPIA2 database, along with its relationship to prognosis. Furthermore, TISIDB was utilized to predict the relationships between HLA-DMB and various immune enhancement factors as well as immunosuppressive factors. Gene Ontology (GO) analysis and Gene Set Enrichment Analysis (GSEA) were employed to explore the signaling pathways associated with HLA-DMB in endometrial cancer. Univariate COX regression analysis was performed to identify prognostic factors for endometrial carcinoma (EC), and a multivariate COX proportional hazards regression model was used to confirm that HLA-DMB can serve as an independent prognostic factor for EC. The protein interaction network of HLA-DMB was constructed using the STRING database, and the chemical drugs related to HLA-DMB were predicted through the CTD database. Finally, the expression of HLA-DMB was validated by qPCR and immunohistochemistry.ResultsThe expression of HLA-DMB at both mRNA and protein levels is significantly higher in UCEC tissues compared to normal tissues. Prognostic analyses indicate that increased expression of HLA-DMB correlates with improved patient prognosis, suggesting its potential as an independent prognostic factor for UCEC. Furthermore, in endometrial cancer, elevated levels of HLA-DMB are associated with higher immune infiltration scores and are closely related to various immune-enhancing factors. Mechanistically, HLA-DMB primarily participates in CD22-mediated regulation of B cell receptors (BCR), leading to BCR antigen activation and the production of second messengers. In our drug analysis, we identified several chemical agents associated with HLA-DMB, including cisplatin, dexamethasone, and ethinylestradiol.DiscussionThis study elucidates the function and underlying mechanisms of HLA-DMB in UCEC, providing a potential biomarker and target for immunotherapy in this disease.
Effectiveness and safety of pembrolizumab, nivolumab, and atezolizumab as adjuvant therapy for high-risk muscle-invasive urothelial carcinoma: an indirect comparison
Authors: Chen Wei , Yoshida Soichiro , Miura Noriyoshi , Fukuda Shohei , Fukushima Hiroshi , Waseda Yuma , Tanaka Hajime , Fujii Yasuhisa 
Published: January 2025

BackgroundThe effectiveness of immune checkpoint inhibitors (ICIs) as adjuvant therapy for muscle-invasive urothelial carcinoma (MIUC) with high recurrence risk has been demonstrated. With no direct efficacy comparisons available, we aimed to indirectly compare the efficacy and safety of pembrolizumab, nivolumab, and atezolizumab as adjuvant treatments for high-risk MIUC based on individual patient data (IPD) from clinical trials.MethodsIPD was reconstructed using the Shiny method from Kaplan–Meier curves of eligible randomized controlled trials. We compared disease-free survival (DFS), overall survival (OS), PD-L1 positive DFS between treatments, and assessed treatment-related adverse events (TRAE).ResultsFour studies including 2,220 high-risk MIUC patients showed no statistically significant difference between the three agents in terms of DFS (pembrolizumab vs. nivolumab: HR 0.97, 95% CI 0.79–1.18; pembrolizumab vs. atezolizumab: HR 0.85, 95% CI 0.70–1.04; nivolumab vs. atezolizumab: HR 0.90, 95% CI 0.74–1.10). All three agents showed comparable DFS outcomes in PD-L1 positive patients (pembrolizumab vs. nivolumab: HR 1.16, 95% CI 0.83–1.60; pembrolizumab vs. atezolizumab: HR 0.85, 95% CI 0.84–1.14; nivolumab vs. atezolizumab: HR 0.79, 95% CI 0.57–1.09), with similar DFS rates 24- and 36-months post-treatment (pembrolizumab: 53.3% and 46.8%; nivolumab: 48.5% and 44.8%; Atezolizumab: 45.0% and 40.7%). OS data showed no significant differences between pembrolizumab and nivolumab (HR 1.16, 95% CI: 0.90–1.49), pembrolizumab and atezolizumab (HR 1.02, 95% CI: 0.81-1.30), and nivolumab and atezolizumab (HR 0.87, 95% CI: 0.69–1.09). TRAE incidence varied but remained manageable (any grade: 26.4% pembrolizumab, 78.6% nivolumab, 54% atezolizumab; grade ≥3: 21.8% pembrolizumab, 18.2% nivolumab, 16.0% atezolizumab).ConclusionsAll three agents showed similar efficacy with manageable safety profiles, positioning them as promising adjuvant therapies for MIUC. These results provide an evidence-based framework for clinical decision-making despite the lack of direct comparative data.
Association between dietary antioxidants, serum albumin/globulin ratio and quality of life in esophageal squamous cell carcinoma patients: a 7-year follow-up study
Authors: Zhang Juwei , Zhou Jinsong , Chen Siting , Huang Yue , Lin Zheng , Deng Yuan , Qiu Minglian , Xiang Zhisheng , Hu Zhijian 
Published: January 2025

ObjectiveThis study aimed to explore the association between dietary antioxidant index (DAI) combined with serum albumin-to-globulin ratio (AGR) and postoperative Health-related quality of life (HRQOL) in patients with esophageal squamous cell carcinoma (ESCC).MethodsAll patients were newly diagnosed with ESCC and underwent radical esophagectomy. Dietary data and routine blood tests were collected preoperatively to compute DAI and AGR. HRQOL was assessed over 7 years post-surgery via telephone follow-up and analyzed longitudinally using a time to deterioration (TTD) model. The deterioration times were compared using the log-rank test, and the association of the combined DAI and AGR index with postoperative quality of life in ESCC patients was examined through Cox regression models.ResultsA total of 238 ESCC patients were included in the study. The results indicate that compared to the low DAI-AGR group, the high DAI-AGR group had a lower rate of deterioration events, and the time to deterioration in emotional functioning (p=0.014), dysphagia (p=0.042), and speech problems (p=0.023) were significantly delayed. Cox proportional hazard model revealed that preoperative high DAI-AGR was associated with improvement in emotional functioning (HR=0.575, 95% CI: 0.368-0.898) and speech problems (HR=0.525, 95% CI: 0.298-0.925) in ESCC patients postoperatively, which remained significant even after adjusting for covariates. The stratified analysis revealed that this improvement was associated with demographic and clinical characteristics.ConclusionsOur findings suggest that high preoperative DAI-AGR is linked to enhanced postoperative HRQOL in ESCC patients, offering crucial insights for patients, practitioners, and researchers.
Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis
Authors: Kumar Rahul , Spadaro Jane Z. , Kahana Alon 
Published: January 2025

PurposeWe describe an unusual case of a rapidly progressive pilomatricoma along the left brow, which was initially misdiagnosed and treated as preseptal cellulitis. Although rare, pilomatricomas and other adnexal tumors should be considered in the differential diagnosis of a growing mass near the brow.Case presentationA 29-year-old male presented to the emergency department with a progressively enlarging left brow lesion, initially noted 3 weeks prior. Exam revealed an erythematous left subbrow mass that measured 2.5 x 2 cm, with resultant mechanical ptosis. The lesion was initially misdiagnosed and treated as preseptal cellulitis, with concern for abscess. The patient ultimately underwent excisional biopsy of the lesion and pathology revealed pilomatricoma.ConclusionsPilomatricoma has similarities to more common skin lesions. Lack of pain or tenderness are important clues against an infectious or inflammatory etiology. Complete surgical excision is therapeutic and allows for diagnostic confirmation. Histopathology is required to rule out pilomatrix carcinoma, a malignant variant.
Self-inflicted partial epiphyseolysis of the distal femur—a case report
Authors: Kanewska Anna , Krause Johannes , Perl Mario 
Published: January 2025

IntroductionInjuries to the epiphyseal plate are of great concern as they can affect bone growth. Although epiphyseal fractures are common in adolescents, fractures of the distal femoral epiphyseal plate are rare.Case presentationWe present a case of a Salter–Harris type 1 fracture of the distal epiphysis of the femur that was self-inflicted by a patient with paraplegia due to spina bifida. The patient was brought to the pediatrician's attention during a routine checkup with an apparent swelling of the right thigh. Upon presentation, we performed a radiograph and an additional MRI, which revealed a partial ventero-medial epiphyseolysis, consistent with a Salter–Harris type 1 fracture. Due to the dislocation, we indicated closed reduction with K-wires. Repositioning was performed using a modified Kapandji maneuver and was completed with additional K-wires.ConclusionDistal epiphyseolysis is a relatively rare injury that can lead to serious complications. Therefore, although rare, epiphyseal fractures should be considered in pediatric patients presenting with uncertain limb swelling.
Efficacy of Tui Na in idiopathic constipation in children with cerebral palsy: a randomized controlled clinical trial
Authors: Wang Huijuan , Chen Bichan , Long Qian , Yang Qiuping , Mao Jiawen , Ma Qinghua , Yi Xingqian , Wang Ying , Liu Yinghan , Cao Zhiliang , Xu Jianda , Ye Yong , Tang Wei 
Published: January 2025

ObjectiveTo investigate the efficacy and potential adverse events of Tuina therapy for idiopathic constipation in children with cerebral palsy (CP).MethodsA total of 60 CP children with idiopathic constipation were enrolled and randomly divided into Tuina and control groups. The control group was treated with basic treatment and 12 sessions of lactulose oral solution, whereas the Tuina group received basic treatment and 12 sessions of infantile Tuina treatment. The following parameters were compared: the Bristol stool form scale (BSFS), the Constipation Assessment Scale (CAS) and the improvement in constipation. In addition, adverse effects were recorded.ResultsAt 4 weeks after the final treatment, the percentage of infants whose constipation improved was 23 (76.7%) in the Tuina group and 21 (70.0%) in the control group (P = 0.771). Initially, the CAS score, weekly bowel movements and proportion of infants with bowel evacuation ≥2 h were comparable between the two groups (P &gt; 0.05). At 4 weeks after the final treatment, the CAS score, weekly bowel movements and proportion of infants with bowel evacuation ≥2 h all significantly improved (P &lt; 0.05) compared with those in the initial situation. However, no difference was found in either group at 4 weeks after the final treatment. No serious adverse reactions (such as diarrhea, abdominal pain, vomiting, subcutaneous redness, skin breakage, or syncope) were recorded.ConclusionsTuina was as effective as medical care in addition to basic treatment for both groups. The results of this study suggest that Tuina, as a nonpharmacological therapy, may be helpful as an alternative treatment for constipation. More advanced research and large-sample studies should be conducted.
Fosaprepitant as combination therapy to prevent chemotherapy-induced vomiting in children: a meta-analysis
Authors: Shi Yanshuo , Yue Yuanyuan , Zhang Yue , Pang Guoxun 
Published: January 2025

ObjectiveTo systematically evaluate the clinical efficacy and safety of fosaprepitant combined with 5-hydroxytryptamine 3 receptor antagonists (5-HT3RA) (with or without dexamethasone) on the chemotherapy-induced vomiting in pediatric cancer patients.MethodsPubMed, Embase, Cochrane Library, China Journal full-text database (CNKI), Wanfang data knowledge service platform (Wanfang) and VIP Chinese sci-tech Journal full-text database (VIP) were searched by computer (retrieval time from database establishment to Apr. 2024), randomized controlled trials (RCTs) and cohort studies about fosaprepitant and 5-HT3RA with or without dexamethasone (observation group) versus 5-HT3RA, with or without dexamethasone, as the control group for chemotherapy-induced vomiting were collected, after data extraction and quality evaluation, meta-analysis was carried out by Rev Man 5.3 software.ResultsA total of 731 patients were included in 7 trials. Meta-analysis results showed that the complete response (CCR, no vomiting/rescue medication) rates were higher in the observation group compared to that in the control group during the acute [the relative risk: RR = 1.64, 95% confidence interval: 95%CI = 1.35–1.99, P &lt; 0.00001], delayed vomiting [RR = 2.05, 95%CI = 1.32–3.17, P = 0.001] and overall phases [RR = 2.08, 95%CI = 1.69–2.57, P &lt; 0.00001], with statistical significance (P &lt; 0.05). The subgroup analysis of salvage treatment proportion revealed that the need for rescue medication was higher for patients in the control than fosaprepitan regimens [RR = 0.20, 95%CI = 0.08–0.54, P = 0.001] There was no difference in the incidence of adverse drug reaction between two groups [RR = 0.95, 95%CI = 0.75–1.19, P = 0.66].ConclusionFosaprepitant in combination with 5-HT3RA (with or without dexamethasone) has the same safety and more effective in preventing chemotherapy-induced vomiting than 5-HT3RA with or without dexamethasone.
Synergistic effects of chemical and biochemical fertilization on yield enhancement and oil quality optimization in ‘Zard’ olive cultivars
Authors: Tadayon Mohammad Saeed , Asgharzadeh Ahmad , Mousavi Seyed Majid , Saghafi Kobra 
Published: January 2025

PurposeThis research evaluates the combined impact of chemical and biological fertilizers on ‘Zard’ olive trees, aiming to reduce chemical dependency, enhance fertilizer efficiency, and improve nutritional value, yield, and oil quality from 2020 to 2023.MethodA factorial design within a randomized complete block was used, focusing on the first factor, soil chemical fertilizer application (CF) at three levels, 100% (CF100), 75% (CF75), and 50% (CF50) of the fertilizer requirement as determined by soil testing. This was coupled with foliar applications of 20-20-20 NPK fertilizer with micronutrients. The second factor, biological fertilizer application (BF), also comprised three levels: BF0 (control), soil-applied organic fertilizer without biological agents; BF1, which included a soil application of an organic fertilizer mix, mycorrhizal fungi, and the beneficial bacteria Bacillus subtilis and Pseudomonas fluorescens, supplemented with fulvic acid and amino acids; and BF1+BFF, where trees were treated with both soil and foliar applications of the aforementioned bacterial species, fulvic acid, and amino acids.ResultsThe CF100+BF1+BFF treatment significantly increased fruit length (31.14%), diameter (41.61%), flesh thickness (30.48%), fresh weight (38.76%), dry weight (55.68%), and yield per tree (27.00%) compared to the control (CF100+BF0). Principal Component Analysis (PCA) identified CF100+BF1+BFF, CF75+BF1+BFF, and CF50+BF1+BFF as superior treatments for fruit characteristics, while CF50+BF1+BFF excelled in oil quality indicators.ConclusionThe study recommends the CF75+BF1+BFF and CF50+BF1+BFF treatments for concurrent improvements in fruit and oil quality. The combined use of biological fertilizers with reduced chemical fertilizers is considered the superior and optimal approach for fertilizing ‘Zard’ cultivar olive orchards.