bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the nutritional values of yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) larvae as an animal feed ingredient: a review
Authors: Syahrulawal Linggawastu , Torske Magnhild Oust , Sapkota Rumakanta , Næss Geir , Khanal Prabhat 
Published: December 2023

AbstractYellow mealworm larvae (YML; Tenebrio molitor) are considered as a valuable insect species for animal feed due to their high nutritional values and ability to grow under different substrates and rearing conditions. Advances in the understanding of entomophagy and animal nutrition over the past decades have propelled research areas toward testing multiple aspects of YML to exploit them better as animal feed sources. This review aims to summarize various approaches that could be exploited to maximize the nutritional values of YML as an animal feed ingredient. In addition, YML has the potential to be used as an antimicrobial or bioactive agent to improve animal health and immune function in production animals. The dynamics of the nutritional profile of YML can be influenced by multiple factors and should be taken into account when attempting to optimize the nutrient contents of YML as an animal feed ingredient. Specifically, the use of novel land-based and aquatic feeding resources, probiotics, and the exploitation of larval gut microbiomes as novel strategies can assist to maximize the nutritional potential of YML. Selection of relevant feed supplies, optimization of ambient conditions, the introduction of novel genetic selection procedures, and implementation of effective post-harvest processing may be required in the future to commercialize mealworm production. Furthermore, the use of appropriate agricultural practices and technological improvements within the mealworm production sector should be aimed at achieving both economic and environmental sustainability. The issues highlighted in this review could pave the way for future approaches to improve the nutritional value of YML.
A novel botnet attack detection for IoT networks based on communication graphs
Authors: Muñoz David Concejal , Valiente Antonio del-Corte 
Published: December 2023

Abstract
Intrusion detection systems have been proposed for the detection of botnet attacks. Various types of centralized or distributed cloud-based machine learning and deep learning models have been suggested. However, the emergence of the Internet of Things (IoT) has brought about a huge increase in connected devices, necessitating a different approach. In this paper, we propose to perform detection on IoT-edge devices. The suggested architecture includes an anomaly intrusion detection system in the application layer of IoT-edge devices, arranged in software-defined networks. IoT-edge devices request information from the software-defined networks controller about their own behaviour in the network. This behaviour is represented by communication graphs and is novel for IoT networks. This representation better characterizes the behaviour of the device than the traditional analysis of network traffic, with a lower volume of information. Botnet attack scenarios are simulated with the IoT-23 dataset. Experimental results show that attacks are detected with high accuracy using a deep learning model with low device memory requirements and significant storage reduction for training.

Graphical abstract
The landscape of patellofemoral arthroplasty research: a bibliometric analysis
Authors: Yang Yao , Chen Yuan , Wang Yingjie , Wang Junjie , Lu Baoliang , Zhu Wanbo , Yang Ning , Zhu Junchen , Zhu Chen , Zhang Xianzuo 
Published: December 2023

Abstract
Purpose
Patellofemoral arthroplasty (PFA) was shown to be a potentially effective surgical technique for isolated patellofemoral osteoarthritis but varying reports on PFA-related implant failure and complications have rendered the procedure controversial. This study aimed to identify impactful publications, research interests/efforts, and collaborative networks in the field of PFA research.

Methods
The study used the Web of Science Core Collection (WOSCC) database, Medline, Springer, BIOSIS Citation Index, and PubMed to retrieve relevant publications on PFA research published between 1950–2022. Statistical tests in R software were used for analysis while VOSviewer, Bibliometrix, and CiteSpace were employed for data visualization.

Results
Two hundred forty-one articles were analyzed with the number of published papers increasing over time. Knee was the most frequent journal and Clinical Orthopaedics and Related Research was the most cited journal. Clinical outcomes, such as prosthesis survival, revision, and complications, were researched most frequently as demonstrated by keyword analysis. The United States was the top contributor to cooperative networks, followed by the United Kingdom while Technical University Munich formed close ties among authors.

Conclusion
Publications on PFA research have witnessed a notable surge. They primarily came from a limited number of centers and were characterized by low-level evidence. The majority of studies primarily focused on the clinical outcomes of PFA, while revision of PFA and patient satisfaction have emerged as new research areas.
Occurrence and health risks of heavy metals in crayfish (Procambarus clarkii) from Jiangsu province, China
Authors: Bian Huan , Zhu Yongzhi , Wen Limin , Ma Jingjing , Li Pengpeng , Geng Zhiming , Wang Daoying , Xu Weimin 
Published: December 2023

AbstractConcentrations of arsenic (As), cadmium (Cd), mercury (Hg) and lead (Pb) in crayfish from Jiangsu province, China, were measured and their health risks were evaluated. For crayfish from both crayfish-rice culture system (CRCS) and crayfish intensive culture system (CICS), concentrations of As, Cd and Pb in whole body of crayfish (WB) were significantly higher than those in abdominal muscle of crayfish (AM), while concentration of Hg in WB was significantly lower than that in AM. No significant difference in concentrations of the heavy metals was found between CRCS and CICS. Concentrations of the heavy metals in AM from both systems were below the limit set by the national standard of China. Estimated daily intake values of the heavy metals were far below the provisional tolerable daily intakes set by Joint FAO/WHO committee on Food Additives, and the corresponding hazard quotient and hazard index were below one. Therefore, consumption of crayfish with the average daily consumption rate (DCR) could be generally regarded as safe. For the consumption with two more times of average DCR during peak season, there might be a potential health risk from intakes of As and Hg in abdominal muscle of crayfish.
Graphical Abstract
Measuring nurses’ on-shift physical activity and sedentary time by accelerometry or heart rate monitoring: a descriptive case study illustrating the importance of context
Authors: Chappel Stephanie E. , Aisbett Brad , Considine Julie , Ridgers Nicola D. 
Published: December 2023

Abstract
Background
There is debate whether nurses are active enough stemming from differences in measurement tools, clinical contexts, and nursing tasks. A descriptive case study concerning the use of device-based measures in combination with direct observation is presented to examine the effect of the nursing context and the discrepancies between different measurement tools for identifying nurses’ on-shift activity levels.

Methods
Data were collected across seven shifts in medical and surgical wards. Nurses’ activity was assessed using accelerometry and heart rate monitoring, in addition to direct observation. Data graphs were plotted for each shift and measurement device, with direct observations used to contextualise the data and identify discrepancies.

Results
Higher activity levels were recorded on-shift through heart rate monitoring (87%) compared to accelerometry (27%). This pattern was also observed specifically on early, late, and medical ward shifts. Data discrepancies between the two devices stemmed from the shift and (or) ward type, highlighting the importance of understanding the context of nursing duties when assessing nurses’ activity levels.

Conclusions
It is also vital that researchers, policymakers, and practitioners consider how they will measure nurses’ occupational physical activity, which consequently will influence outcomes, and therefore, decisions around the need (or not) for intervention.
CNS Efficacy of Osimertinib With or Without Chemotherapy in Epidermal Growth Factor Receptor–Mutated Advanced Non–Small-Cell Lung Cancer
Authors: Jänne Pasi A. , Planchard David , Kobayashi Kunihiko , Cheng Ying , Lee Chee Khoon , Valdiviezo Natalia , Laktionov Konstantin , Yang Tsung-Ying , Yu Yan , Kato Terufumi , Jiang Liyan , Chewaskulyong Busyamas , Lucien Geater Sarayut , Maurel Jean-Marc , Rojas Carlos , Takahashi Toshiaki , Havel Libor , Shepherd Frances A. , Tanaka Kentaro , Ghiorghiu Dana , Amin Neha P. , Armenteros-Monterroso Elena , Huang Xiangning , Chaudhry Ammar Ahmed , Yang James Chih-Hsin 
Published: December 2023

PURPOSE We report CNS efficacy of first-line osimertinib plus chemotherapy versus osimertinib monotherapy in patients with epidermal growth factor receptor ( EGFR)–mutated advanced non–small-cell lung cancer (NSCLC) from the phase III FLAURA2 study according to baseline CNS metastasis status. METHODS Patients were randomly assigned to osimertinib plus platinum-pemetrexed (combination) or osimertinib monotherapy until disease progression or discontinuation. Brain scans were performed in all patients at baseline and progression and at scheduled assessments until progression for patients with baseline CNS metastases; scans were assessed by neuroradiologist CNS blinded independent central review (BICR). RESULTS On the basis of baseline CNS BICR, 118 of 279 (combination) and 104 of 278 (monotherapy) randomly assigned patients had ≥one measurable and/or nonmeasurable CNS lesion and were included in the CNS full analysis set (cFAS); 40 of 118 and 38 of 104 had ≥one measurable target CNS lesion and were included in the post hoc CNS evaluable-for-response set (cEFR). In the cFAS, the hazard ratio (HR) for CNS progression or death was 0.58 (95% CI, 0.33 to 1.01). In patients without baseline CNS metastases, the HR for CNS progression or death was 0.67 (95% CI, 0.43 to 1.04). In the cFAS, CNS objective response rates (ORRs; 95% CI) were 73% (combination; 64 to 81) versus 69% (monotherapy; 59 to 78); 59% versus 43% had CNS complete response (CR). In the cEFR, CNS ORRs (95% CI) were 88% (73 to 96) versus 87% (72 to 96); 48% versus 16% had CNS CR. CONCLUSION Osimertinib plus platinum-pemetrexed demonstrated improved CNS efficacy compared with osimertinib monotherapy, including delaying CNS progression, irrespective of baseline CNS metastasis status. These data support this combination as a new first-line treatment for patients with EGFR-mutated advanced NSCLC, including those with CNS metastases.
Analysis of Vocational Learning in Business Management Program Regarding The Requirements of work Competencies in Business and Industry Sector
Authors: Manopo Meiske , Ponggohong Laurens , Makapedua Jacob Tatoel , Makapedua Juliet 
Published: December 2023

The current era of global economic integration undoubtedly brings consequences among the involved nations. One of the most evident consequences is the emergence of intense competition among these countries, particularly in the labor workforce. Workforce competence is crucial for businesses to remain competitive in this global competition. The knowledge and skills possessed by the workforce are inseparable from the education process. The rapid advancements of technology pose challenges for education systems to produce Human Resources (HR) capable of global engagement. Polytechnic State of Manado, as a vocational educational institution tasked with producing educated labor with global competence aligned with the needs of the business and industrial, continuously evaluates and enhances the educational processes to adapt to the dynamic industrial landscape. The analysis conducted should focus on aligning the knowledge and skills taught with the facilities available, such as the Investment Gallery Lab, Computer Lab, and Entrepreneurship Lab, to support appropriate learning implementation. Additionally, the application of teaching methods should encourage students to actively engage in the learning process. The research focus is the analysis of the learning implementation that supports achieving graduate competencies required by the industry and business world. The sub-focus is to analyze the facilities and infrastructure of laboratories in the learning process within the Business Administration department at Polytechnic State of Manado
Pemanfaatan Limbah Kertas Semen, Serat Bambu, dan Serat Fiber Sebagai Bahan Tambah Pembuatan Plafon Gypsum
Authors: Akbar Agam Fauzie , Sentosa Khalid Al Rasyid , H Hartono , Fauziyah Shifa 
Published: December 2023

The ceiling is a part of building construction that serves as the ceiling of the building. The ceiling industry is an industry that easily keeps up with the times with various innovations produced. Therefore, with the innovation of bamboo fiber, fiber fiber and paper pulp as added materials to the gypsum ceiling, it can be optimized as raw material for making gypsum ceilings. The purpose of this study is to optimize cement paper waste, bamboo fiber waste and fiber fiber to optimize waste around the environment as gypsum ceiling added material to produce gypsum ceiling with better quality. The method used is research and experiments with job mix used is the addition of 0%, 1.5%, 2%, 2.5%, 3% cement pulp waste 0%, 1.5%, 2%, 2.5%, 3% bamboo fiber waste, , 0%, 1.5%, 2%, 2.5%, 3% fiber fiber. The results of the study can be seen that the highest flexural strength of 138.89 kgf / cm2 occurs in the percentage composition of 2.5% bamboo fiber, fiber fiber and cement pulp compared to the bending strength of normal variations, in the best water absorption how much in the composition of 1.5% fiber fiber with a value of 9.09% better than the normal ceiling, the best moisture content is in the composition of 2% bamboo fiber-cement pulp and 2.5% bamboo fiber, fiber fiber and cement pulp compared to normal ceiling. However, from the results of the price analysis, it can be seen that the variation in the percentage of 2.5% bamboo fiber, bamboo fiber and cement pulp requires a higher cost than the normal ceiling with a difference of Rp. 38.00.
STRATEGIC MANAGEMENT OF THE ECONOMIC SUSTAINABILITY OF A COMPANY IN THE PARADIGM OF FUZZY LOGIC
Authors: Malyukov Yu. A. , Nedosekin A. O. , Abdoulaeva Z. I. 
Published: December 2023

The theory of economic resilience is actively developing in Russian and foreign scientific studies. Most of them lack a comprehensive approach to the issue of resilience, the ability to assess the behaviour of economic systems under conditions of uncertainty and to offer optimal solutions to ensure the resilience of economic systems (enterprises, industries) in difficult conditions. It is necessary to develop optimal algorithms for managing economic systems under adverse effects (AE) of a natural, technological, or military nature. The article describes the method of managing economic resilience in three-dimensional spaces: ‘stability – efficiency’, ‘risk – efficiency’, and ‘chance – efficiency’. The results of three approaches to resilience management are compared.It can be tentatively assumed that the stability of an individual company is ensured if the economic stability index RI exceeds the level of 0.6 and the return on equity is at least 20% per annum. More generally, in the ‘resilience – efficiency’ space, the domain of stable states of the enterprise is described by a fuzzy parabolic R lens. In the ‘risk – efficiency’ and ‘chance – efficiency’ domains, the space of optimal solutions is represented by a set of non-dominated Pareto alternatives, united by a fuzzy parabolic efficient bound of the solution portfolio set. The organisation can control its level of economic resilience within multiple representations and act according to a predetermined plan in the event of a temporary loss of resilience. The research is original, using the methods of fuzzy set theory and soft computing. A technology has been proposed to ensure the economic resilience of systems operating in difficult conditions (e.g. in new regions of the Russian Federation where large-scale military actions are taking place). This makes the study highly relevant and practical.
BEHAVIORAL AND COGNITIVE FACTORS IN THE FORMATION OF THE HEURISTIC MODEL OF THE EFFECTIVE INTERPRETER IN INVESTING IN HIGH-TECH COMPANIES
Authors: Ilkevich S. V. 
Published: December 2023

The article presents a systematisation of the main factors of cognitive distortions and behavioural heuristics that make the switch to the effective interpreter model irreversible in portfolio investments, especially in high-tech companies. As the heuristic model of the effective interpreter can be perceived as generally increasing the risks in the system for all stakeholders at the current stage of the evolution of the investment system, the author focuses on the most negative manifestations of cognitive and behavioural factors in his description in the publication. However, this does not mean that it is possible or desirable to return to the rational investor model, as narrative and storytelling’s components are too important in the context of ‘new economy’ industry formation and and fast business expansion by disruptive companies. To better interpret the business potential of companies, stakeholders, especially investors, increasingly need to work with narratives, storytelling, aspects of perception and business trust, rather than the numerical values and ratios of financial reporting and analytics. This is partly due to the fact that the intangible assets of companies in the S&P500 index have accounted for up to 90% of the total market capitalisation over the last two decades.The author identifies the most significant cognitive and behavioral factors: the increase in the narrative component of equity value, the ‘fake it till you make it’ approach, the proliferation of cryptocurrencies as the asset with the largest narrative component of value, the boom in IPOs and SPACs in 2020-2021, buybacks as an unproductive signalling tool, the popularisation of chasing triple digit returns based on the survivor bias, the popularity of momentum strategies, the over-reliance on analyst recommendations and assessments, ‘pump and dump’ schemes, investment gamification and investor extroversion, anchoring and framing, the sunk cost fallacy, the lack of rigorous techniques for invalidating investment theses, and the perception of free money in investing over the past decade and a half. Awareness and tracking of at least the most significant behavioural and cognitive factors in the formation and further development of the heuristic model of the ‘effective interpreter’ will help to reduce risks in the financial and investment system of the ‘new economy’ and increase the sustainability of its long-term development.
Formulation and characterization of Naringin - niosomes for sustained drug delivery and wound healing properties
Authors: Krithika R, Leelarani Ravilla, S Perumal, Padmini R  
Published: December 2023

Naringin, a natural flavonoid abundantly found in citrus fruits, has garnered significant attention for its diverse pharmacological properties, including antioxidant, anti-diabetic, and wound healing effects. However, its limited bioavailability and rapid metabolism have posed challenges for its therapeutic application. In this study, we present the development and characterization of a novel Naringin-loaded niosomal conjugation aimed at enhancing its therapeutic potential. This encapsulation not only improves the solubility and stability of naringin but also offers controlled release properties. The niosomal preparation was prepared using a thin-film hydration method, incorporating Naringin into the lipid bilayers. The physicochemical characterization confirmed the successful encapsulation of Naringin within the niosomal structure, resulting in improved stability and sustained release properties. In vitro release studies demonstrated a prolonged release of Naringin over an extended period, suggesting its potential for sustained therapeutic effects. Antioxidant activity of the preparation was evaluated by DPPH and ABTS assay, revealing enhanced scavenging of free radicals compared to free Naringin. The naringin-niosomal conjugation exhibited an IC50 value of 97.89 µg/ml for DPPH and 50.6µg/ml for ABTS assay. Naringin-niosomal preparation showed enhanced cell migration after 72 h of injury in a scratch wound healing assay with 95% wound healing efficiency. Overall, our findings indicate that the developed Naringin-loaded niosomal preparation holds promise as a multifunctional therapeutic agent with prolonged antioxidant, and wound healing effects. This innovative preparation may offer a valuable approach to harness the therapeutic potential of Naringin, addressing the limitations associated with its bioavailability and providing a foundation for further pre-clinical and clinical investigations.
Identification of B- cell and T- cell specific peptide vaccine for Histoplasma capsulatum
Authors: Andrew Benedict, Sathish Sankar  
Published: December 2023

Histoplasma capsulatum is an environmental dimorphic fungus. H. capsulatum infections are primarily acquired, and there is no person-to-person transmission with the rare exception of organ transplantation. The objective of this research is to identify a B-cell and T-cell specific peptide vaccine for H. capsulatum by analyzing the outer membrane protein, predicting B-cell and T-cell epitopes, and selecting a candidate peptide vaccine with high homology to the pathogen and strong MHC I-binding potential
Evaluation of Anti-Inflammatory and Analgesic Property of Methanolic Extract of Momordica Dioica in Wistar Rat Model
Authors: Vrushali Neve  , Jui Darbhe  , Vrushali Bhalchim  , Pawan Karwa  , Jaymala Kumawat  , Suchita Gokhale  , Dr. Rupali Yewale  , Pritam Kutal  
Published: December 2023

Background: Since current medications frequently cause potentially serious side effects, countless individuals continued to have pain and inflammation despite the accessibility of treatments. Ancient practitioners have used a variety of herbal remedies with analgesic and anti-inflammatory properties extensively. Momordica Dioica is one of them, but no experimental research has been done in support of this traditional use. Objective: The purpose of the research was to assess the analgesic and anti-inflammatory properties of methanolic Momordica Dioica fruit extracts. Methods: Dryed by air According to OECD guideline the version eighteen, the fruit of Momordica Dioica is extracted with the solvent methanol as well as an acute oral toxicity study was done for the methanol-based extract of Momordica Dioica. The Active Constituent responsible for the Activity was confirmed by HPTLC method. The hot plate method was employed to assess the analgesic efficacy of centrally mediated analgesia.The ability to reduce inflammation was assessed using a carrageenan-induced paw oedema test. Results: Momordica dioica's methanolic extract inhibits the ceiling result during activity. The Methanolic Extract of Momordica dioica (MEMD) extract demonstrated a significant (p 0.0001) analgesic effect in the hot plate method at doses of 100mg/kg and in all combinations with standard. Maximum anti-inflammatory effects were seen in carrageenan-induced paw edema starting 2-4 hours after induction, and all tested doses of the extract significantly inhibited the carrageenan-induced inflammation (p 0.0001, p 0.001). The presence of a pentacyclic terpenoid i.e Ursolic acid present in the extract had potential analgesic and anti-inflammatory activity which supports the traditional claim.