bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Race With Functional and Clinical Outcomes With the REHAB‐HF Multidomain Physical Rehabilitation Intervention for Older Patients With Acute Heart Failure
Authors: Gilbert Olivia N. , Mentz Robert J. , Bertoni Alain G. , Kitzman Dalane W. , Whellan David J. , Reeves Gordon R. , Duncan Pamela W. , Nelson Michael Benjamin , Blumer Vanessa , Chen Haiying , Reed Shelby D. , Upadhya Bharathi , O'Connor Christopher M. , Pastva Amy M. 
Published: October 2023

Background
The REHAB‐HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) randomized trial demonstrated that a 3‐month transitional, tailored, progressive, multidomain physical rehabilitation intervention improves physical function, frailty, depression, and health‐related quality of life among older adults with acute decompensated heart failure. Whether there is differential intervention efficacy by race is unknown.

Methods and Results

In this prespecified analysis, differential intervention effects by race were explored at 3 months for physical function (Short Physical Performance Battery [primary outcome], 6‐Minute Walk Distance), cognition, depression, frailty, health‐related quality of life (Kansas City Cardiomyopathy Questionnaire, EuroQoL 5‐Dimension‐5‐Level Questionnaire) and at 6 months for hospitalizations and death. Significance level for interactions was
P
≤0.1. Participants (N=337, 97% of trial population) self‐identified in near equal proportions as either Black (48%) or White (52%). The Short Physical Performance Battery intervention effect size was large, with values of 1.3 (95% CI, 0.4–2.1;
P
=0.003]) and 1.6 (95% CI, 0.8–2.4;
P
<0.001) in Black and White participants, respectively, and without significant interaction by race (
P
=0.56). Beneficial effects were also demonstrated in 6‐Minute Walk Distance, gait speed, and health‐related quality of life scores without significant interactions by race. There was an association between intervention and reduced all‐cause rehospitalizations in White participants (rate ratio, 0.73 [95% CI, 0.55–0.98];
P
=0.034) that appears attenuated in Black participants (rate ratio, 1.06 [95% CI, 0.81–1.41];
P
=0.66; interaction
P
=0.067).

Conclusions
The intervention produced similarly large improvements in physical function and health‐related quality of life in both older Black and White patients with acute decompensated heart failure. A future study powered to determine how the intervention impacts clinical events is required.

REGISTRATION

URL:
https://www.clinicaltrials.gov
. Identifier: NCT02196038.
Genome‐Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants
Authors: Salih Ahmed , Ardissino Maddalena , Wagen Aaron Z. , Bard Andrew , Szabo Liliana , Ryten Mina , Petersen Steffen E. , Altmann André , Raisi‐Estabragh Zahra 
Published: October 2023

BACKGROUND
Pericardial adipose tissue (PAT) is the visceral adipose tissue compartment surrounding the heart. Experimental and observational research has suggested that greater PAT deposition might mediate cardiovascular disease, independent of general or subcutaneous adiposity. We characterize the genetic architecture of adiposity‐adjusted PAT and identify causal associations between PAT and adverse cardiac magnetic resonance imaging measures of cardiac structure and function in 28 161 UK Biobank participants.

METHODS AND RESULTS

The PAT phenotype was extracted from cardiac magnetic resonance images using an automated image analysis tool previously developed and validated in this cohort. A genome‐wide association study was performed with PAT area set as the phenotype, adjusting for age, sex, and other measures of obesity. Functional mapping and Bayesian colocalization were used to understand the biologic role of identified variants. Mendelian randomization analysis was used to examine potential causal links between genetically determined PAT and cardiac magnetic resonance–derived measures of left ventricular structure and function. We discovered 12 genome‐wide significant variants, with 2 independent sentinel variants (rs6428792,
P
=4.20×10
−9
and rs11992444,
P
=1.30×10
−12
) at 2 distinct genomic loci, that were mapped to 3 potentially causal genes: T‐box transcription factor 15 (
TBX15
), tryptophanyl tRNA synthetase 2, mitochondrial (
WARS2
) and early B‐cell factor‐2 (
EBF2
) through functional annotation. Bayesian colocalization additionally suggested a role of RP4‐712E4.1. Genetically predicted differences in adiposity‐adjusted PAT were causally associated with adverse left ventricular remodeling.

CONCLUSIONS
This study provides insights into the genetic architecture determining differential PAT deposition, identifies causal links with left structural and functional parameters, and provides novel data about the pathophysiological importance of adiposity distribution.
Acute Heart Failure Is a Malignant Process: But We Can Induce Remission
Authors: Cotter Gad , Davison Beth A. , Lam Carolyn S. P. , Metra Marco , Ponikowski Piotr , Teerlink John R. , Mebazaa Alexandre 
Published: October 2023

ABSTRACT
Acute heart failure is a common and increasingly prevalent condition, affecting >10 million people annually. For those patients who survive to discharge, early readmissions and death rates are >30% everywhere on the planet, making it a malignant condition. Beyond these adverse outcomes, it represents one of the largest drivers of health care costs globally. Studies in the past 2 years have demonstrated that we can induce remissions in this malignant process if therapy is instituted rapidly, at the first acute heart failure episode, using full doses of all available effective medications. Multiple studies have demonstrated that this goal can be achieved safely and effectively. Now the urgent call is for all stakeholders, patients, physicians, payers, politicians, and the public at large to come together to address the gaps in implementation and enable health care providers to induce durable remissions in patients with acute heart failure.
‘I Dance, I Revolt’
Authors: Silverstein Shayna M. 
Published: October 2023

Abstract
During the intensification of migration and border politics throughout Europe in the mid-2010s, displaced Syrians fleeing war to seek asylum and a livable life were simultaneously welcomed as vulnerable strangers who could contribute to European economies and societies and perceived as threats to the imaginaries of a homogenous Europe. This essay critiques the logic embedded in this narrative, namely that migrants are a social factor external and destabilizing to Europe, through a critical interpretation of Syrian choreographer Mithkal Alzghair’s work, Displacement (2016). This provocative dance work pivots on Alzghair’s reimagining of dabke, Syria’s celebrated folk dance, in which he deconstructs the social relations and embodied aesthetics of popular dabke practices to forge a political critique of Syrian authoritarianism and forced migration. By crafting a repertoire of movement that critiques the aesthetic and political ideologies on which it is based, Displacement arguably disrupts the postcolonial imaginaries of national identity and place that have historically ensconced folk dance in Syria and in Europe, respectively, and transforms the possibilities of what cultural heritage connotes, represents and signifies for Syrians and Europeans. Instead, the destabilizing work of embodied performance reveals how instability is endemic to European spaces and society. Through the convergence of performance theory and praxis, this essay demonstrates how Displacement stages live, perpetual, repetitive, and embodied motion in ways that open a space for artists and audiences to collectively engage with a fractious period and reconfigure the complex relations of power and representation situated between Syria and Europe.
The Characteristics of Rituals and Their Imprint on Chinese Culture
Authors: Hu Xinsheng 
Published: October 2023

Abstract
The concept of li (rites) in ancient China encompasses three levels of meaning, namely: the rituals and ceremonies themselves, moral ethics, and a system of political hierarchy. While these three levels are related to each other, they each carry specific characteristics. When people today discuss issues such as the origins of rites, they rarely analyze the concept of rites according to these different levels, thus causing the topic at hand to be vague, ambiguous, and inchoate. In most research, both “rites” and the “rituals” refer specifically to the level of the ritual per se. “Rites” include both folk rituals and state rituals, the latter of which refers to what is commonly termed the “rituals,” that is, the part of rites with state background and political coercion. The fundamental difference between the rituals and other statutes and institutions lies in rituals’ performative, symbolic, and standardized nature. Their performative and symbolic nature bestowed upon the rites a special significance and publicity function which transcend everyday life. At the same time, their standardized and formulaic nature made these rites highly organized and institutionalized, while allowing them to reinforce the social and political hierarchy. The highly mature rituals in ancient China allowed both characteristics of these rituals to be developed to their fullest, thus giving rise to Chinese culture’s emphasis on performance and form.
Perturbing Parameters to Understand Cloud Contributions to Climate Change
Authors: Duffy Margaret L. , Medeiros Brian , Gettelman Andrew , Eidhammer Trude 
Published: October 2023

Abstract
The sensitivity of cloud feedbacks to atmospheric model parameters is evaluated using a CAM6 perturbed parameter ensemble (PPE). The CAM6 PPE perturbs 45 parameters across 262 simulations, 206 of which are used here. The spread in the total cloud feedback and its six components across the CAM6 PPE are comparable to the spread across the CMIP6 and AMIP ensembles, indicating that parametric uncertainty mirrors structural uncertainty. However, the high-cloud altitude feedback is generally larger in the CAM6 PPE than WCRP assessment, CMIP6, and AMIP values. We evaluate the influence of each of the 45 parameters on the total cloud feedback and each of the six cloud feedback components. We also explore whether the CAM6 PPE can be used to constrain the total cloud feedback, with inconclusive results. Further, we find that despite the large parametric sensitivity of cloud feedbacks in CAM6, a substantial increase in cloud feedbacks from CAM5 to CAM6 is not a result of changes in parameter values. Notably, the CAM6 PPE is run with a more recent version of CAM6 (CAM6.3) than was used for AMIP (CAM6.0) and has a smaller total cloud feedback (0.56 W m−2 K−1) as compared to CAM6.0 (0.81 W m−2 K−1) owing primarily to reductions in low clouds over the tropics and midlatitudes. The work highlights the large sensitivity of cloud feedbacks to both parameter values and structural details in CAM6.
Age at diagnosis and diagnostic delay across attention-deficit hyperactivity and autism spectrums
Authors: Knott Rachael , Mellahn Olivia J , Tiego Jeggan , Kallady Kathryn , Brown Louise E , Coghill David , Williams Katrina , Bellgrove Mark A , Johnson Beth P 
Published: October 2023

Background: Despite the known benefits of accurate and timely diagnosis for children with attention-deficit hyperactivity disorder and autism spectrum disorders (autism), for some children this goal is not always achieved. Existing research has explored diagnostic delay for autism and attention-deficit hyperactivity disorder only, and when attention-deficit hyperactivity disorder and autism co-occur, autism has been the focus. No study has directly compared age at diagnosis and diagnostic delay for males and females across attention-deficit hyperactivity disorder, autism and specifically, attention-deficit hyperactivity disorder + autism. Methods: Australian caregivers ( N = 677) of children with attention-deficit hyperactivity disorder, autism or attention-deficit hyperactivity disorder + autism were recruited via social media ( n = 594) and the Monash Autism and ADHD Genetics and Neurodevelopment Project ( n = 83). Caregivers reported on their child’s diagnostic process. Diagnostic delay was the mean difference between general initial developmental concerns and the child’s attention-deficit hyperactivity disorder and autism diagnosis. Results: Children with autism were significantly younger at autism diagnosis than the attention-deficit hyperactivity disorder + autism group (ηp2 = 0.06), whereas children with attention-deficit hyperactivity disorder were significantly older at attention-deficit hyperactivity disorder diagnosis than the attention-deficit hyperactivity disorder + autism group (ηp2 = 0.01). Delay to attention-deficit hyperactivity disorder and autism diagnosis was significantly longer in the attention-deficit hyperactivity disorder + autism group compared to attention-deficit hyperactivity disorder (ηp2 = 0.02) and autism (η2 = 0.04) only. Delay to autism diagnosis for females with autism (η2 = 0.06) and attention-deficit hyperactivity disorder + autism (η2 = 0.04) was longer compared to males. Conclusions: Having attention-deficit hyperactivity disorder + autism and being female were associated with longer delays to diagnosis. The reasons for these delays and possible adverse effects on outcomes require further study.
Congenital versus acquired optic disc pit maculopathy: An OCT based study
Authors: Prabhu Vishma , Venkatesh Ramesh , Kathare Rupal , Acharya Isha , Mangla Rubble , Handa Ashit , Yadav Naresh Kumar , Chhablani Jay 
Published: October 2023

Purpose The purpose of this study is to describe and compare the demographic, ocular, and imaging characteristics of a cohort of patients with congenital and acquired optic disc pit maculopathy (ODPM). Methods This retrospective case series included patients diagnosed with ODPM between June 2017 and April 2023. These patients’ baseline demographics, ocular characteristics, and optical coherence tomography (OCT) imaging characteristics and follow up changes were analyzed. Results A total of 14 eyes with ODPM were identified (9 congenital and 5 acquired). Eyes with congenital ODP developed maculopathy at a younger age, presented commonly with visual symptoms, and exhibited an obvious pit at the temporal foveal margin as well as a high cup: disc ratio ( p < 0.05). Primary open-angle glaucoma was identified in all five eyes with acquired ODPM. On OCT, eyes with acquired ODPM lacked the characteristic nerve fibre layer schisis, outer retinal layer hole, and foveal serous macular detachment ( p < 0.05) unlike congenital ODPM. At the final follow-up visit, two cases from the congenital ODPM group and one case from the acquired ODPM group displayed complete resolution of maculopathy. The two cases of congenital ODPM were treated with pars plana vitrectomy and laser barrage to the optic disc margin, while the solitary case of acquired ODPM was treated with trabeculectomy surgery alone. Conclusion Clinical examination and baseline OCT imaging reveal distinct differences between congenital and acquired ODPM eyes. These characteristics may help with accurate diagnosis and treatment planning for these two distinct clinical entities.
Nonpharmacological Interventions for Preventing Rehospitalization Among Patients with Heart Failure: A Systematic Review and Meta-Analysis
Authors: Alnomasy Nader , Still Carolyn Harmon 
Published: October 2023

Background Heart failure (HF) is the most common condition for rehospitalization among people aged ≥65 years in the United States, with 35,197,725 hospitalizations between 2014 and 2017. Hospitalized patients with HF have the highest 30-day readmission rate (25%). Overall, HF management, despite its progress, remains a challenge. Although several studies have evaluated interventions designed to reduce HF-related hospital readmissions, research comparing their effectiveness remains insufficient. Purpose This systematic review and meta-analysis focused on studies that investigated the effectiveness of nonpharmacological interventions (NPIs) on reducing rehospitalization among patients with HF. Methods This review conformed to the preferred reporting items for systematic reviews and meta-analyses guidelines, used four databases: Cumulative index to Nursing and Allied Health Literature, PubMed, Cochrane, and Web of Science. Studies were included in the review according to the following criteria: (a) included only randomized control trials (RCTs), (b) included participants with HF who were over 18 years of age, (c) peer-reviewed, (d) written in English, and (e) rehospitalizations occurring within 30-day, 90-day, and 1 year of discharge from the initial hospitalization. Results Fourteen studies were included, with a total of 2,035 participants. Meta-analysis showed that rehospitalization was different between the intervention and usual care groups. The odds ratio was 0.54 (95% confidence interval [0.36, 0.82, p < 0.01]). Conclusions/Implications for Practice NPIs designed to increase HF knowledge and self-management may effectively reduce rehospitalization among HF patients. NPIs can be delivered at the patient's home through visits, phone calls, or digital platforms and technologies.
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Authors: Sun Jian , Chen Yan , Wang Tao , Ali Waseem , Ma Yonggang , Yuan Yan , Gu Jianhong , Bian Jianchun , Liu Zongping , Zou Hui 
Published: October 2023

AbstractMitochondrial transfer regulates intercellular communication, and mitochondria regulate cell metabolism and cell survival. However, the role and mechanism of mitochondrial transfer in Cd-induced nonalcoholic fatty liver disease (NAFLD) are unclear. The present study shows that mitochondria can be transferred between hepatocytes via microtubule-dependent tunneling nanotubes. After Cd treatment, mitochondria exhibit perinuclear aggregation in hepatocytes and blocked intercellular mitochondrial transfer. The different movement directions of mitochondria depend on their interaction with different motor proteins. The results show that Cd destroys the mitochondria-kinesin interaction, thus inhibiting mitochondrial transfer. Moreover, Cd increases the interaction of P62 with Dynactin1, promotes negative mitochondrial transport, and increases intracellular lipid accumulation. Mitochondria and hepatocyte co-culture significantly reduced Cd damage to hepatocytes and lipid accumulation. Thus, Cd blocks intercellular mitochondrial transfer by disrupting the microtubule system, inhibiting mitochondrial positive transport, and promoting their negative transport, thereby promoting the development of NAFLD.
Graphical Abstract
Mobility-as-a-Service users: insights from a trial in Sydney
Authors: Smith Göran , Hensher David A. , Ho Chinh , Balbontin Camila 
Published: October 2023

AbstractThe positive effects that Mobility-as-a-Service (MaaS) is envisioned to have on transport can only be reaped if people are using MaaS. Yet, the understanding of the user perspective on MaaS is incomplete and primarily based on experiments with non-users. To address this shortcoming, this paper reports user experiences from a trial of a high-level MaaS service in Sydney, Australia. Based on questionnaires and interviews, it analyses who participated in the trial and why, and whether the trial experience satisfied their motives. The contribution to the literature on MaaS is three-fold. Firstly, most of the people that participated in the trial were frequent users of both public transport and private cars. This supports the notion that multi-modal travellers are likely early adopters of MaaS and contradicts the fear that MaaS does not appeal to private car users. Secondly, a desire to contribute to innovation and curiosity about MaaS were the main motives for signing up for the trial, which highlights the important role an inviting setting for experimentation, such as a trial, can play in stimulating MaaS adoption. Thirdly, many participants struggled with making the trialled service work for them and on average they seemed to value the support and feedback functions higher than other service features. This underscores the novelty of MaaS, compared to existing service models, and reiterates the notion that more than an app and a few subscription plans is needed to make MaaS useful for users.
Construction of a high-density genetic linkage map and QTL mapping of growth and cold tolerance traits in Takifugu fasciatus
Authors: Zhang Ying , Li Jie , Chu Peng , Shang Ruhua , Yin Shaowu , Wang Tao 
Published: October 2023

AbstractTakifugu fasciatus is an aquaculture species with high economic value. In recent years, problems such as environmental pollution and inbreeding have caused a serious decline in T. fasciatus germplasm resources. In this study, a high-density genetic linkage map was constructed by whole-genome resequencing. The map consists of 4891 bin markers distributed across 22 linkage groups (LGs), with a total genetic coverage of 2381.353 cM and a mean density of 0.535 cM. Quantitative trait locus (QTL) localization analysis showed that a total of 19 QTLs associated with growth traits of T. fasciatus in the genome-wide significance threshold range, distributed on 11 LGs. In addition, 11 QTLs associated with cold tolerance traits were identified, each scattered on a different LG. Furthermore, we used QTL localization analysis to screen out three candidate genes (IGF1, IGF2, ADGRB) related to growth in T. fasciatus. Meanwhile, we screened three candidate genes (HSP90, HSP70, and HMGB1) related to T. fasciatus cold tolerance. Our study can provide a theoretical basis for the selection and breeding of cold-tolerant or fast-growing T. fasciatus.