bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: SYNTHESIS OF AZACOUMARINS. III. 4‐HYDROXY‐5‐AZACOUMARIN AND 4‐HYDROXY‐7‐AZACOUMARIN
Authors: DEJARDIN J.‐V. , LAPIERE C.‐L. 
Published: November 2023

AbstractBei der Umsetzung der 3‐Hydroxy‐nicotinsäure (I) mit dem Chlorester (II) bildet sich das gemischte Anhydrid (III) mit O‐acylierter Gruppe; Kondensation von (III) mit dem Grignard‐Reagenz (IV) liefert das Derivat (V), das durch Hydrolyse und Decarboxylierung das Ethoxycarbonyl‐hydroxyazacumarin (VI) gibt; Erhitzen von (VI) mit PPA verläuft unter Abspaltung der Ester‐Gruppe zu (VII).
ChemInform Abstract: PHOTOCYCLIZATION OF 1,2‐DIARYLPYRIDINIUM CATIONS AND THE PHOTOBIS‐CYCLIZATION OF 1,2,6‐TRIARYLPYRIDINIUM CATIONS. X‐RAY CRYSTAL STRUCTURE OF 9‐PHENYL‐2,10B‐DIAZADIBENZO(FG,OP)NAPHTHACENIUM PERCHLORATE
Authors: KATRITZKY A. R. , ZAKARIA Z. , LUNT E. , JONES P. G. , KENNARD O. 
Published: November 2023

AbstractDie Pyridiniumverbindung (I) cyclisiert bei der Photolyse zum Kation (II).
ChemInform Abstract: 3‐PYRIDAZONYL ACIDS AND SOME DERIVATIVES
Authors: ISMAIL M. F. , SHAMS N. A. , ABDEL RAHMAN S. E. , FATEEN A. K. 
Published: November 2023

AbstractDie Dihydropyridazinone (I) reagieren mit Acrylnitril (II) in Gegenwart starker Basen zu N‐Cyanethylderivaten (III), deren alkalische Hydrolyse die Carbonsäuren (IV) liefert.
ChemInform Abstract: CONDENSATIONS WITH HYDRAZINE‐N,N′‐DICARBOXAMIDINE. XXIII. FLUORINATED β‐DIKETONES AS REACTION PARTNERS
Authors: KREUTZBERGER A. , RISSE G. 
Published: November 2023

AbstractDie Kondensation der Trifluoirmethylketone (I) mit Diguanidin (II) liefert über die isolierbare Zwischenstufe (III) die Hydrazinderivate (IV) und die Heterocyclen (V).
ChemInform Abstract: THIOUREA AND PYRIMIDINE DERIVATIVES FROM CHALCONE
Authors: WEBER F. G. , PUSCH U. , BRAUER B. 
Published: November 2023

AbstractDas aus Chalkon und Ammoniumisothiocyanat hergestellte Isothiocyanatopropanon (I) reagiert im Gegensatz zu Aussagen früherer Autoren mit Aminen nicht zum Dihydropyrimidin (III), sondern zum Tetrahydropyrimidinthion (II), wie durch das Fehlen der SH‐Valenzschwingung im IR‐Spektrum bewiesen wird.
ChemInform Abstract: SYNTHESIS OF STEREOCHEMICAL SYSTEMS HAVING A SILICON (OR GERMANIUM)‐PHOSPHORUS BOND
Authors: DUBAC J. , CAVEZZAN J. , MAZEROLLES P. , ESCUDIE J. , COURET C. , SATGE J. 
Published: November 2023

AbstractAus dem Isomerengemisch der Silacyclopentane (I) werden durch Alkoholyse und Reduktion sowie durch Thiolyse und Reduktion die Z‐ und E‐isomeren Silacyclopentane (III) und (V) hergestellt.
ChemInform Abstract: STUDIES ON DIAZO COMPOUNDS AND AZIDES. XXXII. SUBSTITUTION REACTIONS AT THE DIAZO CARBON OF DIAZOMETHYLPHOSPHORYL COMPOUNDS
Authors: REGITZ M. , WEBER B. , ECKSTEIN U. 
Published: November 2023

AbstractDer Diazomethylphosphonsäureester (IIIc) wird mit βutyläLi zum Derivat (IV) metalliert, das nur unter ‐50°C einigermaßen haltbar ist und sich durch Umsetzung mit Benzoylbromid, Triphenylchlorosilan, mit Benzaldehyd oder Chloral bei anschließender Hydrolyse in das Acyl‐ (Va), das Silyl‐Derivat (Vb) bzw. die aldolartigen Produkte (Vc) überführen läßt. Die Ein‐ Führung einer Nitrogruppe in (IIIa‐d) erfolgt mit N205; neben den Nitrodiazoalkanen (I) werden die Salpetersäureester (II) gebildet.
ChemInform Abstract: A CONVENIENT SYNTHESIS OF MONOFLUOROGERMANES
Authors: DRAKE J. E. , GLAVINCEVSKI B. M. , RUTHERFORD K. G. 
Published: November 2023

AbstractDie bei ‐196°C im Vakuum kondensierten Monobromogermane (I) reagieren bei der Behandlung mit einem Überschuß an PbO/SbF3 (1:1) zu den meist sublimierbaren, feuchtigkeitsempfindlichen Fluoriden (II).
ChemInform Abstract: RING EXPANSION AND CLEAVAGE REACTIONS OF CYCLODISTANNAZANES
Authors: HAENSSGEN D. , POHL I. 
Published: November 2023

AbstractDas Diazadistannetidin (III) reagiert mit dem Acetylendicarboxylat (II) oder mit Diphenylcarbodiimid (IV) unter Ringerweiterung zu den sechsgliedrigen Heterocyclen (I) bzw. (V).
ChemInform Abstract: CHROMIUM(III) HETEROCOMPLEXES. IV. ISOTHIOCYANATE COMPLEXES OF CHROMIUM(III) WITH SOME MONODENTATE IMIDAZOLES
Authors: MISHRA A. , SINGH J. P. 
Published: November 2023

AbstractHexaisothiocyanatochromat(III) reagiert mit Imidazol beim Rückflußkochen in EtOH nach Verdünnen mit Wasser zu dem Imidazol‐Komplex (I).
ChemInform Abstract: ADDITION OF DIMETHYLCYANAMIDE TO HEXAKIS(ALKOXY)DIMOLYBDENUM COMPOUNDS
Authors: CHISHOLM M. H. , KELLY R. L. 
Published: November 2023

AbstractDie reversible Addition von Dimethylcyanamid an die entsprechenden Hexakis‐[alkoxy]dimolybdän‐Verbindungen führt zu den luft‐ und feuchtigkeitsempfindlichen 1:1‐Addukten (I).
ChemInform Abstract: PREPARATION AND MONOLAYER PROPERTIES OF SURFACTANT TRIS(2,2′‐BIPYRIDINE)RUTHENIUM(II) DERIVATIVES
Authors: VALENTY S. J. , BEHNKEN D. E. , GAINES G. L. JUN. 
Published: November 2023

AbstractDie Synthesen der drei Bipyridy1‐Ru(II)‐Komplexe (I)‐(III), die hydrolytisch stabile oberflächenaktive Bindungen und verschiedene Molekülladungen besitzen, sowie die Eigenschaften ihrer monomolekularen Schichten werden beschrieben Der oberflächenaktive Ligand 4,4′‐Di‐n‐nonadecylbipyridin‐(2,2′) wird durch Raney‐ Ni‐Kupplungsreaktion aus 4‐n‐Nonadecylpyridin, Alkylierungsprodukt vom 4‐Methyl‐ pyridin‐Carbanion mit n‐Octadecylchlorid (Ausb. 43%), in l4proz. Ausb. dargestellt.
ChemInform Abstract: NEW RUTHENIUM(II) SYSTEMS
Authors: CHAKRAVARTY A. R. , CHAKRAVORTY A. 
Published: November 2023

AbstractHydratisiertes Ru(III)‐chlorid reagiert mit zwei Molen der entsprechenden Arylazooxime bzw. α‐Benzilmonooxim in siedendem Ethanol unter N2 zu den Dichloro‐Ru(II)‐Komplexen (II) bzw. (IV) (keine Ausb.‐Angabe).
ChemInform Abstract: A NEW SYNTHESIS OF SPIROVETIVANES VIA THE SPIRO ACYLOIN INTERMEDIATE
Authors: IBUKA T. , HAYASHI K. , MINAKATA H. , ITO Y. , INUBUSHI Y. 
Published: November 2023

AbstractDiels‐Alder‐ Reaktion von (I) und (II) und nachfolgende Hydrolyse geben den Ketoester (IIIa), der mit Ethandithiol das Dithioacetal (IIIb) liefert.
ChemInform Abstract: MOLECULAR REARRANGEMENT IN DITERPENES
Authors: BANERJEE A. K. 
Published: November 2023

AbstractDie säurekatalysierte Umlagerung des Phera anthrenderivats (I) mit Polyphosphorsäure liefert die Produkte (IIa), (IIb), (III) und (IV); mit H2SO4 werden (IIa) und das Isomere (V) erhalten.
ChemInform Abstract: THERMALLY‐INDUCED EXTRUSION OF SULFUR DIOXIDE FROM ALLYL ALKYL SULFONES. USE OF THE REARRANGEMENT FOR THE SYNTHESIS OF DIHYDROJASMONE
Authors: LITTLE R. D. , WOLF S. , SMESTAD T. , SEIKE S. C. , LINDNER L. W. JUN. , PATTON L. 
Published: November 2023

AbstractAus dem Acrolein‐Derivat (I) wird in mehreren Schritten das Sulfon (IId) und hieraus durch thermische SO2‐Eliminierung der Ester (IIIa) bzw. das Na‐Salz der Säure (IIIb) gewonnen.
ChemInform Abstract: SYNTHESIS OF ANHYDRIDES OF THE A‐SECOSTEROID SERIES WITH 10β‐METHYL OR 1‐β‐(METHOXYCARBONYL) SUBSTITUTED
Authors: SNATZKE G. , WESSLING B. 
Published: November 2023

AbstractDie Dicarbonsäureanhydride (VII) werden, wie im Schema angegeben, aus den Cholestanonen (I) erhalten.
ChemInform Abstract: A NEW AND CONVENIENT SYNTHESIS OF 2‐DEOXY‐D‐RIBOSE FROM 2,4‐O‐ETHYLIDENE‐D‐ERYTHROSE
Authors: HAUSKE J. R. , RAPOPORT H. 
Published: November 2023

AbstractAus dem Aldehyd (I) entstehen nach verschiedenen Verfahren die Konden‐ sate (IIa), die zu Sulfoxiden (IIb) oxidiert werden.
ChemInform Abstract: SELECTIVE N‐ACYLATION OF KANAMYCIN A
Authors: CRON M. J. , KEIL J. G. , LIN J.‐S. , RUGGERI M. V. , WALKER D. 
Published: November 2023

AbstractKanamycin Aergibt mit Hexamethyldisilazan in siedendem Acetonitril Polytrimethylsilyl‐kanamycin A, das durch Behandlung mit N‐((2S)‐4‐Benzyloxycarbonylamino‐2‐hydroxy‐butanoyloxy)‐succinimid bei 5°C für l Std., anschließende Hydrolyse mit Wasser bei pH 2,5 und Hydrogenolyse in ca. 50%iger Ausbeute zum Amid (Ia) und in ca. 5%iger Ausbeute zum Amid (Ib) führt.
ChemInform Abstract: THE TOTAL SYNTHESIS OF (.+‐.)‐LUCIDULINE
Authors: SZYCHOWSKI J. , MACLEAN D. B. 
Published: November 2023

AbstractDas Cyclohexandion (III) ‐ dargestellt aus den Estern (I) und (II) wird nach Reinshagen mit dem Nitril (IV) zu dem Derivat (V) alkyliert, aus dem mit Oxalylchlorid das Chlorolefin (VI) zugänglich ist.
ChemInform Abstract: BERBERIDIC ACID
Authors: CHINNASAMY P. , SHAMMA M. 
Published: November 2023

AbstractJe nach Reaktionsbedingungen läßt sich Berberidsäure (IIa) ‐ dar‐h gestellt durch Oxidation von Berberin (I) mit HNO3 ‐ in den Diester (IIb) bzw. in die Betaine (IIc) und (IId) überführen.
ChemInform Abstract: SYNTHESIS AND STUDY OF THE BIOLOGICAL ACTIVITY OF INDOLE NUCLEOSIDES. IV. SYNTHESIS OF 1‐α‐L‐ARABINOPYRANOSIDES OF SUBSTITUTED INDOLES AND 7‐AZAINDOLES
Authors: MUKHANOV V. I. , SOKOLOVA T. N. , NIKOLAEVA T. G. , DOBRYNIN YA. V. , PREOBRAZHENSKAYA M. N. 
Published: November 2023

AbstractDie Indoline (I) und (II) bzw. das Aza‐indolin (XVII) reagieren mit Arabinose (IV) und weiter mit Acetanhydrid/Pyridin zu den Nucleosiden (V), (VI) und (XIX), die zu Indolnucleosiden (VII) und (VIII), bzw. dem Azaindolnucleosid (XX) oxidiert werden können.
ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐PROSTAGLANDIN D1: USE OF TRIETHYLSILYL PROTECTING GROUPS
Authors: HART T. W. , METCALFE D. A. , SCHEINMANN F. 
Published: November 2023

AbstractDer Trimethylsilylether (I) reagiert mit dem Organocuprat (II) zum PGE1‐Vertreter (III), der mit Natriumborhydrid zu den Methylestern (IVa) und (IVb) reduziert wird.
ChemInform Abstract: STEREOSELECTIVE SYNTHESIS OF THE PROPOSED AMERICAN CONEFLOWER JUVENILE HORMONE MIMIC. SOME OBSERVATIONS ON THE CYCLOPROPYLCARBINYL REARRANGEMENT IN SUBSTITUTED SYSTEMS
Authors: COOKE M. P. JUN. 
Published: November 2023

AbstractAus dem Carbinol (II) erhält man mit HBr und Zinkbromid das Spaltprodukt (I), während in Eisessig die Folgeprodukte (III)‐(V) erhalten werden.
ChemInform Abstract: DIFFERENTIAL PULSE POLAROGRAPHIC DETERMINATION OF SELENIUM AND TELLURIUM AND THEIR MIXTURES
Authors: STARA V. , KOPANICA M. 
Published: November 2023

AbstractSe(IV) stört (durch Ablagerung von elementarem Se auf der Oberfläche der Hg‐Tropfelektrode) die differential‐pulspolarographische Bestimmung von Te(IV).
Hybrid Integration of Au Nanoplates and Ag Nanoparticles with Controlled Nanogaps via Cu2O‐mediated Galvanic Replacement Reaction: Plasmonic Catalysis and Photothermal Conversion
Authors: Zhang Di , Sun Haoyu , Kong Haixia , Ma Yanyun , Min Yuanyuan , Wang Yi , Wang Yingying , Zheng Yiqun 
Published: November 2023

AbstractRational assembling of different noble metal nanocrystals with controlled nanogaps in one entity allows the efficient coupling of electromagnetic fields of each component and versatile manipulation over the overall physiochemical properties. In the present study, we report a stepwise synthetic strategy to hybridlike assemble Au nanoplate and Ag nanoparticles without direct physical contact. Particularly, the success of current work relies on the conformal coating of Cu2O over the Au nanoplate as an intermediate layer, followed by the in situ formation of Ag nanoparticles via the galvanic replacement reaction between Cu2O and Ag+. With the anchoring of Ag nanoparticles over the Cu2O‐wrapped Au nanoplate, the resulting hybrid nanostructures exhibit noticeable multiple plasmonic absorptions across the UV‐vis‐NIR region. The potential use as the plasmonic catalyst for current Au@Cu2O‐Ag hybrid products is validated using reduction of 4‐nitrophenol as the model reaction, where the catalytic performance is greatly improved by the UV‐vis light irradiation. They also exhibit satisfactory photothermal conversion performance under the irradiation of Xe lamp. The current work provides a niche strategy to create noble‐metal hybrid nanostructures with controlled interparticle distance and tunable plasmonic properties, could be extended to other noble metal or alloys.
Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H‐Bearing N‐Heterocycles
Authors: Loison Anaïs , Hanquet Gilles , Toulgoat Fabien , Billard Thierry , Panossian Armen , Leroux Frédéric R. 
Published: November 2023

AbstractInvited for this issue's Front Cover is the group of Frédéric. R. Leroux. The cover picture illustrates the potential of difluoromethoxylated ketones as building blocks for accessing challenging structures bearing the key OCF2H motif. These are represented here by a rocket, a highly technical achievement. Obviously, a parallel can be drawn between the building block strategy and a famous construction game. On the righthand side of the cover we can see the rocket heading towards a cell, highlighting the importance of fluorinated molecules in life sciences. Cover design by A. Loison. Read the full text of the article at 10.1002/ejoc.202300695.
The Effect of Intermolecular Interactions between Aromatic Ring‐Containing Insulators and Semiconductors in Pentacene Thin‐Film Transistors
Authors: Zhu Jiufu , Li Shizhang , Bai Dacheng , Pan Dongye , Zou Jiawei , Zheng Yan , Zhang Bowen , Hao Xiaojuan , Wang Wei , Shi Zuosen , Cui Zhanchen 
Published: November 2023

AbstractMobility is an important parameter to estimate the performance of organic thin‐film transistors, one of the key factors affecting the mobility is the first several semiconductors molecular layers near the insulator surface. A strategy is proposed to introduce aromatic‐rings in the gate insulating layer to modulate the growth of pentacene, thus a series of aryl group containing polymers by reversible‐addition‐fragmentation chain‐transfer polymerization is synthesized for the preparation of organic thin‐film transistor insulators. The semiconductor layer is evaporated on the polymer insulators at room temperature. As the inducing function of the aromatic ring, greater weak interactions between dielectric materials and semiconductors by simulation, which makes the initial pentacene layer weak epitaxial growth, therefore pentacene could form better morphology, especially larger crystal domains and uniform thin‐film continuity. The results show that precision design and synthesis of polymer insulator layers provide new methods to achieve high performance of organic thin‐film transistors with easier fabricating process.
Risk Factors Associated with Delays in Hearing Loss Identification in Pediatric Patients
Authors: Lindeborg Michael M. , Khalsa Inderpreet Kaur , Liao Elizabeth N. , Stephans Jihyun R. , Chan Dylan K. 
Published: November 2023

AbstractObjectiveTo identify sociodemographic factors associated with pediatric late‐identified hearing loss (LIHL) and classify novel subgroups within the LIHL population.Study DesignRetrospective cohort.SettingTertiary children's hospital.MethodsOur cohort included children with permanent hearing loss (HL) between 2012 and 2020 (n = 1087). Patients with early‐identified HL were compared to patients with LIHL (>6 months of age at diagnosis), and 3 subgroups: (1) late‐identified congenital HL: failed NHS but had a diagnostic audiogram >6 months old; (2) late‐onset HL: passed NHS and identified with HL after 6 months old; (3) late‐identified, unknown‐onset: unknown NHS results, identified after 6 months old. Geospatial analysis was performed using ArcGIS Pro.ResultsCompared with early‐identified children, children with LIHL were more likely to have more comorbidities (odds ratio [OR] = 1.12, [1.01, 1.23]), be an under‐represented minority (URM) (OR = 1.92, [1.27, 2.93]) and have a higher social vulnerability index (SVI) (adjusted odds ratio [AOR] = 2.1, [1.14, 3.87]). However, subgroups in the LIHL cohort had variable associations. Children with late‐identified unknown onset hearing loss were uniquely associated with a primarily non‐English speaking household (AOR = 1.84, [1.04, 3.25]), whereas children with late‐onset hearing loss were less likely to have public insurance (AOR = 0.47, [0.27, 0.81]. There were no significant associations for children with late‐identified congenital hearing loss. Neighborhood disadvantage, as measured by SVI, had an increased association with late‐identified unknown onset HL (AOR = 4.08, [2.01, 8.28]) and a decreased association with late‐onset HL (AOR = 0.40, [0.22, 0.72]).ConclusionSociodemographic factors serve as proxies for health care access, and these factors vary across LIHL pathways. Understanding the risk factors associated with each LIHL subgroup may help address disparities in pediatric HL identification.
Quantifying the ice test in halitosis patients
Authors: Aydin Murat , Gunay Ismail , Derici M. Cagri 
Published: November 2023

AbstractObjectivesOdor is in the oral air when halitosis occurs orally. Because oral gases shrink when cooled, oral halitosis disappears when a piece of ice is placed in the patient's mouth. This physical phenomenon provides a basis for distinguishing oral from non‐oral halitosis but has yet to be quantified.Material and methodsThe records of 29 halitosis patients were retrospectively analyzed. Gas concentrations were measured with a portable gas detector (IBRID‐MX6) before and after cooling the mouth with 1 × 1 × 2 cm ice for 30 s. Patients were asked to rate their halitosis. Tongue temperature and oral gas concentrations were compared with paired t‐tests and one‐way ANOVA.ResultsThe tongue cooled by an average of 13.09°C with ice (from 36.0 to 22.4°C). The mean values of the concentrations of VOC, NH3, H2S, and H2 decreased proportionally with cooling: 74.10%, 77.51%, 81.26%, and 96.12%, respectively. The self‐reported halitosis score decreased from 4 to 0 (n = 29, p < 0001).ConclusionsIt can be concluded that the ice test suppresses oral gases in sufficient quantity to detect oral halitosis.
Nanoremediation of toxic dyes using a bacterial consortium immobilized on cellulose acetate nanofiber mats
Authors: Erkoç Esra , Tüzün İmre , Korkmaz Filiz , San Keskin Nalan Oya , Koçberber Kiliç Nur 
Published: November 2023

AbstractStenotrophomonas maltophilia and Ochrobactrum sp. demonstrated the highest rates of dye bioremediation. The trials were performed at pH 8, which resulted in the highest bioremediation rate of 64.6% in media containing 21.2 mg L−1 dye. As the dye concentration increased, the pollutant removal decreased, with the maximum bioremoval rate of 70.3%. The removal capacity was increased with an increase in biomass concentration; the highest yield of 91.3% was obtained in media containing 14.2 mg L−1 dye and 12% (v/v) biomass. In nanoremediation studies, the bacterial consortium was immobilized on cellulose acetate nanofiber mats (CA‐NFM). Scanning electron microscopic micrographs showed that bead‐free nanofiber mats were effective in immobilizing bacterial cells. Moreover, nanofiber structures were capable of supporting exopolysaccharides formation, as confirmed by Fourier transform ınfrared spectroscopy. The bacterial consortium immobilized on CA‐NFM showed a maximum bioremoval rate of 56.5%. Reusability tests demonstrated that the consortium immobilized CA‐NFM could be used at least five times. Furthermore, after leaving the mat for 1 month at 4°C, it was still usable, and the removal efficiency was found to be 45.4%. Based on our findings, bacteria immobilized on CA‐NFM have the potential to be used as highly effective and versatile nanobiotechnological biological sorbents in the treatment of wastewater containing dyes.Highlights
Stenotrophomonas maltophilia and Ochrobactrum sp. were used as a bacterial consortium.
Bacterial consortium immobilized on cellulose acetate nanofiber mats (CA‐NFM) was tested.
EPS production by the consortium was confirmed by Fourier transform ınfrared spectroscopy analysis.
CA‐NFM could be used at least five times.
Histone acetylation is associated with pupal diapause in cotton bollworm, Helicoverpa armigera
Authors: Lu Qin , Li Yan , Liao Jing , Ni Zhaohong , Xia Shunchao , Yang Maofa , Li Haiyin , Guo Jianjun 
Published: November 2023

AbstractBACKGROUNDDiapause is an environmentally preprogrammed period of arrested development that is important to insect survival and population growth. Histone acetylation, an epigenetic modification, has several biological functions, but its role in agricultural pest diapause is unknown. In this study, we investigated the role of histone H3 acetylation in the diapause of Helicoverpa armigera.RESULTSThe histone H3 gene of H. armigera was cloned, and multiple sequence alignment of amino acids revealed that the potential lysine acetylation sites were highly conserved across species. Investigation of histone H3 acetylation levels in diapause‐ and nondiapause‐type pupae showed that acetylation levels were down‐regulated in diapause‐type pupae and were lower in diapausing pupae compared to nondiapause pupae. By screening the genome, six histone acetyltransferase (HAT) and eight histone deacetylase (HDAC) genes responsible for antagonizing catalytic histone acetylation modifications were identified in H. armigera, and most of them exhibited different expression patterns between diapause‐ and nondiapause‐type pupae. To elucidate the effect of histone H3 acetylation on diapause in H. armigera, the diapause pupae were injected with the histone acetylation activator trichostatin A (TSA). The results indicated that TSA injection increased the levels of histone H3 acetylation, causing the diapausing pupae to revert to development. Furthermore, transcriptome analysis revealed that 259 genes were affected by TSA injection, including genes associated with metabolism, resistance, and immunological responses.CONCLUSIONThese results suggest that histone acetylation is inseparably related to the pupal diapause of H. armigera, which promises to be a potential target for pest control. © 2023 Society of Chemical Industry.
Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases
Authors: Zhang Shengxiao , Feng Yige , Yin Xinyu , Su Qinyi , Xi Yujia , Cheng Ting , Zhang Heyi , Xue Yulong , Wang Caihong , Li Xiaofeng 
Published: November 2023

AbstractBackgroundEpidemiological studies have shown a close association between osteoarthritis (OA) and cardiovascular disease (CVD), but reliable evidence needs to be provided. We performed a two‐sample Mendelian randomization (MR) study to examine the potential causal effect between OA and CVD.MethodsExposures were self‐reported OA, knee osteoarthritis (KOA), and hip osteoarthritis (HOA). The outcomes were 12 CVDs, including heart failure, atrial fibrillation, coronary artery disease, pulmonary embolism, stroke and its subtypes, myocardial infarction, coronary heart disease, and primary hypertension. All outcomes were obtained from published genome‐wide association studies. The inverse‐variance weighted method was used as the primary MR analysis. Heterogeneity tests and sensitivity analyses were conducted to validate the accuracy of the MR results.ResultsSelf‐reported OA increased the incidence of small vessel stroke (odds ratio [OR] = 1.25, 95% confidence interval [CI]: 1.02–1.52, p = 0.03) and primary hypertension (1.01 [1.00–1.02], p < 0.01). HOA increased the incidence of stroke (1.06 [1.01–1.11], p = 0.02) and two subtypes (cardioembolic stroke: 1.12 [1.02–1.23], p = 0.02; ischemic stroke: 1.06 [1.01–1.11], p = 0.03). Patients with KOA had an increased risk of heart failure (1.10 [1.04–1.16], p < 0.01), atrial fibrillation (1.08 [1.02–1.13], p < 0.01), small vessel stroke (1.21 [1.06–1.39], p = 0.01), and primary hypertension (1.01 [1.01–1.02], p < 0.01).ConclusionsPatients with OA have an increased risk of several CVDs. The causality of this relationship may have clinical implications for improving the quality of prevention and treatment.