bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gesundheitsförderung, Stresserleben und Arbeitszufriedenheit bei Pflegeauszubildenden
Authors: Schönfeld Simone , Rathmer Ines , Kobs Jule , Onescheit Miriam , Langer Lena , Michaelsen Maren M. , Esch Tobias , Hötger Cosima 
Published: February 2024

Zusammenfassung
Hintergrund
Der Fachkräftemangel erfordert die Förderung der Gesundheit und Arbeitszufriedenheit von angehenden Pflegefachpersonen. Ziel war es, die Wirksamkeit einer Teilnahme an einer dreiteiligen Präsenz-Workshopreihe „Gesunder Start“ (Bedarfserhebung, Bewegung, Entspannung) auf gesundheits- und arbeitsbezogene Outcomes bei Pflegeauszubildenden zu prüfen.

Material und Methoden
Für die quasirandomisierte kontrollierte Studie (DRKS00026027) wurden Pflegeauszubildende im ersten Ausbildungsjahr rekrutiert. Pro Pflegeschule (n = 3) wurde eine Klasse der Interventionsgruppe (IG; n = 47) und eine der Wartekontrollgruppe (WKG; n = 52) zugeteilt. Das primäre Outcome war das Stresserleben (Perceived Stress Scale [PSS-10]). Sekundäre Outcomes beinhalteten weitere gesundheits- und arbeitsbezogene Endpunkte sowie die subjektive Bewertung der Workshops. Die Teilnehmenden wurden vor dem Start des ersten Workshops und 0,5, 2,5 sowie 4 Monate nach dem letzten Workshop (nur IG) per Online-Survey befragt. Nach 2,5 Monaten erhielt die WKG die Intervention.

Ergebnisse
Nach 0,5 Monaten verbesserte sich der PSS-10-Score der IG, wohingegen sich die Werte der WKG verschlechterten. Der Unterschied zwischen den Gruppen war bei der Gesamtskala des PSS-10 nicht signifikant (p = 0,06). Der Unterschied zwischen den Gruppen war für die PSS-10-Subskala „Hilflosigkeit“ signifikant (p = 0,01; d = 0,67; 95 %-KI: 0,14–1,20). Nach 2,5 Monaten gab es keinen Unterschied mehr zwischen den Gruppen (PSS-10-Gesamtskala p = 0,87). Bei den sekundären Outcomes zeigten sich ebenfalls Unterschiede zwischen den Gruppen (p < 0,05), die auf Veränderungen nach 2,5 als auch 4 Monaten hindeuten. Die Zufriedenheit mit den Workshops war insgesamt eher hoch (M = 4,0; SD = 1,0; Skala 1–5).

Schlussfolgerung
Die langfristige Wirksamkeit von Interventionen für Auszubildende in der Krankenpflege sollte verbessert werden, um den schädlichen Folgen der zunehmenden Arbeitsanforderungen dieser Gruppe entgegenzuwirken.
Sodium–glucose cotransporter-2 inhibitors in heart failure patients across the range of body mass index: a systematic review and meta-analysis of randomized controlled trials
Authors: Adamou Anastasia , Chlorogiannis David Dimitris , Kyriakoulis Ioannis G. , Stamatiou Iliana , Koukousaki Despoina , Kardoutsos Ioannis , Sagris Dimitrios , Doehner Wolfram , Ntaios George 
Published: February 2024

AbstractSodium–glucose cotransporter-2 (SGLT2) inhibitors improve outcomes in patients with heart failure, with or without diabetes. We sought to assess whether there is an interaction of these effects with body mass index (BMI). A systematic review of the MEDLINE and Scopus databases (last search: November 15th, 2022) was performed according to the PRISMA statement. Studies eligible for this review were randomized control trials (RCTs) with patients with chronic heart failure with either preserved or reduced ejection fraction randomly assigned to SGLT2 inhibitors or placebo. Data were extracted independently by two reviewers. BMI was classified according to the WHO classification into under/normal weight (BMI: < 25 kg/m2), overweight (BMI: 25–29.9 kg/m2), obesity class I (BMI: 30–34.9 kg/m2), and obesity classes II/III (BMI: ≥ 35 kg/m2). All analyses were performed using RevMan 5.4. Among 1461 studies identified in the literature search, 3 were eligible and included in the meta-analysis. Among 14,737 patients (32.2% were women), 7,367 were randomized to an SGLT2 inhibitor (dapagliflozin or empagliflozin) and 7,370 to placebo. There were significantly fewer hospitalizations for HF (OR: 0.70, 95%CI: 0.64–0.76), cardiovascular deaths (OR:0.86, 95%CI: 0.77–0.97) and all-cause deaths (OR:0.90, 95%CI: 0.82–0.98) in the SGLT2 inhibitors group compared to the placebo group, without any interaction with BMI group (test for subgroup differences: x2 = 1.79, p = 0.62; x2 = 0.27, p = 0.97; x2 = 0.39, p = 0.94, respectively). There is no interaction between the efficacy of SGLT2 inhibitors and BMI in patients with HF with either preserved or reduced ejection fraction. SGLT2 inhibitors are associated with improved outcomes regardless of the BMI.Trial registration: PROSPERO ID: CRD42022383643.
Chronic health conditions after childhood Langerhans cell histiocytosis: Results from the Swiss Childhood Cancer Survivor Study
Authors: Sláma Tomáš , Mader Luzius , Žarković Maša , Malär Reta , Schifferli Alexandra , von der Weid Nicolas X. , Kuehni Claudia E. , Schindera Christina 
Published: February 2024

Abstract
Purpose
Langerhans cell histiocytosis (LCH) is a rare disease characterized by dysregulated proliferation of myeloid marrow progenitors and subsequent organ infiltration. While LCH is associated with a favorable prognosis, some survivors may develop chronic health conditions (CHC) because of the disease. In this study, we aimed to assess the spectrum and prevalence of CHC among LCH survivors compared with siblings and identify factors associated with the development of CHC.

Methods
The Swiss Childhood Cancer Survivor Study sent questionnaires to all ≥ 5-year LCH survivors registered in the Swiss Childhood Cancer Registry and diagnosed between 1976 and 2015. Siblings also received similar questionnaires. We compared CHC prevalence between LCH survivors and siblings and used logistic regression to identify determinants of CHC.

Results
A total of 123 LCH survivors participated in the study, with a response rate of 69%. Median time since diagnosis was 13 years (interquartile range 9–20). Among LCH survivors, 59% had at least one CHC. Cardiovascular (13% vs. 6%), endocrine (15% vs. 2%), musculoskeletal (22% vs. 13%), and digestive (15% vs. 8%) CHC were more common among LCH survivors compared to siblings (all p < 0.05). Factors most strongly associated with the occurrence of CHC were multisystem LCH, multifocal bone involvement, and involvement of the pituitary gland.

Conclusions
More than half of long-term LCH survivors suffered from one or more CHC and were affected considerably more than siblings.

Implications for Cancer Survivors
LCH survivors in follow-up care should be screened especially for cardiovascular, endocrine, musculoskeletal, and digestive conditions.
The successful posterior sectionectomy accompanied with caudate lobectomy for hepatocellular carcinoma located in segment 1 after LEN-TACE: a case report
Authors: Nanashima Atsushi , Hamada Takeomi , Hiyoshi Masahide , Imamura Naoya , Tsuchimochi Yuki , Shimizu Ikko , Nagata Kenji , Kawakami Hiroshi 
Published: February 2024

AbstractNowadays, the novel molecular targeting chemotherapy provides possibility of safe hepatectomy for progressive hepatocellular carcinoma (HCC). Further, combination of the conventional transarterial chemoembolization (TACE) may add an effect of tumor shrink. We present a successful radical hepatectomy for a large HCC located in segment 1 accompanied with the preoperative Lenvatinib (LEN)-TACE sequential treatment. We present a woman patient without any complaints who had a 7 cm-in-size of solitary HCC compressing vena cava and right portal pedicle. To achieve radical hepatectomy by tumor shrinking, LEN-TACE for 2 months. After confirming downsizing or devascularization of the HCC, we scheduled radical posterior sectionectomy combined with caudate lobectomy according to tumor location and expected future remnant liver volume from three-dimensional computed tomography simulation before surgery. Under the thoraco-abdominal incision laparotomy, we safely achieved scheduled radical hepatectomy without any vascular injuries. The postoperative course was uneventful and no tumor recurrence were observed for 1 year. Histological findings showed the Japan TNM stage III HCC with 70% necrosis. The multi-modal strategy of LEN-TACE followed by radical hepatectomy by confirming downsizing or devascularization in tumor is supposed to be useful and would be a preoperative chemotherapy option, and promising for curative treatment in HCC patients with progressive or large HCC, which may lead to safety by prevention surrounding major vascular injury.
Practices of French General Practitioners Regarding Vaccination of Boys Against Human Papillomavirus (HPV), One Year After the Application of Its Official Recommendation
Authors: Hurtaud Aline , Tara Alexandre Abou , Bouazzi Leïla , Pacquelet Yannick , Boiteux-Chabrier Marie , Pham Bach-Nga , Pierre Cavard Hélène , Barbe Coralie 
Published: February 2024

AbstractIn 2019, French health authorities extended the recommendation for human papillomavirus (HPV) vaccination to include boys aged 11 to 19 years. We describe HPV vaccination practices among French general practitioners (GPs) since this recommendation wasapplied. We also identified factors associated with the propensity to propose HPV vaccination to boys. Cross-sectional study, between May and August 2022, among French GPs using a questionnaire asking about the GPs, their practices, and opinions regarding HPV vaccination, including whether they systematically proposed HPV vaccination to eligible boys or not. We investigated factors associated with systematic proposal of HPV vaccination, using univariate and multivariate logistic regression. In total, 360 GPs participated (76.6% females; mean age 34.7 ± 7.8 years; 22.9% had additional training in gynecology or pediatrics); 5.5% reported that they systematically offered HPV vaccination to boys prior to the recommendation, whereas 61.2% do so systematically since the recommendation. Factors associated with systematic proposal to boys (post recommendation) were female GP sex (78.6% versus 66.2%; OR = 2.0 [95% confidence interval (CI) 1.2–3.3]; p = 0.007) and systematic proposal prior to the recommendation (8.5% versus 0.7%; OR = 13.3 [1.7–101.7]; p = 0.01). Protection against HPV-induced cancer was cited as an argument to vaccinate girls (98.3% versus 89.2%; p < 0.0001); while reducing the risk of transmission was more commonly an argument to vaccinate boys (78.1% versus 51.8%; p < 0.0001). This study underlines the positive impact of the official recommendation for HPV vaccination of boys on the attitude of GPs, with an increase in the systematic proposal of HPV vaccination to boys.
Diallel analysis of common bean (Phaseolus vulgaris L.) genotypes for seed dietary fibre, carbohydrate, calcium and phosphorus contents
Authors: Ibram Aladji Abatchoua Madi Madi , Taidi Yadji Haman , Benoit-Constant Likeng Li Ngue , Jean-Baptiste Noubissié Tchiagam , Adamou Ibrahima 
Published: February 2024

AbstractGenetic information of bean seed traits can be an immense help to the breeder in selection of suitable genotypes and the appropriate breeding strategies. Therefore, the investigation aims to assess the genetic variability and to elucidate the genetic analysis of seed dietary fibre, carbohydrate, seed calcium and phosphorus contents of Phaseolus vulgaris in the high Guinean Savannah zone conditions. 5 × 5 half-diallel crosses of these traits were conducted in randomized complete block design with three replications. Results revealed high differences between five lines beans (p < 0.05), suggesting the sufficient genetic diversity for these traits. High broad sense heritability values were recorded for seed dietary fibre, carbohydrate and seed calcium content, attesting a strong implication of the genetic factors in the control of these traits; thereby, these traits can be improved through regular selection. The ratio GCA/SCA was greater than unity only for seed phosphorus content. It indicates the prevalence of additive gene effect in the involvement of the genetic control for this trait. The combining ability analysis revealed highly significant differences between parental GCA effects and F1 cross SCA effects. The PB, BI, CT and PR lines beans will prove useful in common bean breeding programmes as donor genotypes, in the development of bean genetic resources for betterment improvement of nutritional traits.
Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
Authors: Makovski Tatjana T. , Ghattas Jinane , Monnier-Besnard Stéphanie , Cavillot Lisa , Ambrožová Monika , Vašinová Barbora , Feteira-Santos Rodrigo , Bezzegh Peter , Bollmann Felipe Ponce , Cottam James , Haneef Romana , Devleesschauwer Brecht , Speybroeck Niko , Nogueira Paulo Jorge , Forjaz Maria João , Coste Joël , Carcaillon-Bentata Laure 
Published: February 2024

Abstract
Background
Estimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic. It was conducted within the European Union Horizon 2020 program (No: 101018317); Prospero registration: CRD42021249444.

Methods
PubMed, Embase, World Health Organisation COVID-19 Global literature on coronavirus disease, and PsycINFO were searched between January 2020 and 7 April 2021 for multimorbidity and 1 February 2022 for frailty. Quantitative peer-reviewed studies published in English with population-representative samples and validated multimorbidity and frailty tools were considered.

Results
Overall, 9,701 records were screened by title/abstract and 267 with full text. Finally, 14 studies were retained for multimorbidity (etiological role, n = 2; prognostic, n = 13) and 5 for frailty (etiological role, n = 2; prognostic, n = 4). Only short-term outcomes, mainly mortality, were identified. An elevated likelihood of poorer outcomes was associated with an increasing number of diseases, a higher Charlson Comorbidity Index, different disease combinations, and an increasing frailty level.

Discussion
Future studies, which include the effects of recent virus variants, repeated exposure and vaccination, will be useful for comparing the possible evolution of the associations observed in the earlier waves.
The Future of Equivalence in the EU Financial Sector
Authors: Busch Danny 
Published: February 2024

AbstractThe future of equivalence in the EU financial sector does not look all that bright. Granting third-country entities access to the EU financial markets is increasingly less about reliance on equivalent third-country rules and equivalent third-country supervision. Considerations other than equivalence are increasingly given more relative weight, either explicitly or implicitly, in particular (i) EU financial stability risks, (ii) EU market integrity, (iii) EU retail investor protection, (iv) preserving or regaining EU autonomy in an increasingly complex world (e.g., Brexit and the economic rise of China), (v) protecting EU entities against competitors from third countries, (vi) trying to conquer market share in a lucrative business (e.g., derivatives clearing), and (vii) other EU policy considerations. These considerations are gaining ground not merely in relation to the question of whether an equivalence framework should even be in place, and if so, whether equivalence decisions should indeed be taken, but also with regard to the regulatory and supervisory framework that the EU applies to (1) entities established in third countries for which the Commission has adopted equivalence decisions, and (2) third-country branches established in the EU. In view of this, the Territorial Approach and the Extra-Territorial Approach are clearly on the rise, in each case to the detriment of the Equivalence Approach. At the same time, loopholes in the execution of the Territorial Approach continue to exist at the national level, at least for the time being.
Covalently Bonded Ni Sites in Black Phosphorene with Electron Redistribution for Efficient Metal-Lightweighted Water Electrolysis
Authors: Zhai Wenfang , Chen Ya , Liu Yaoda , Ma Yuanyuan , Vijayakumar Paranthaman , Qin Yuanbin , Qu Yongquan , Dai Zhengfei 
Published: February 2024

AbstractThe metal-lightweighted electrocatalysts for water splitting are highly desired for sustainable and economic hydrogen energy deployments, but challengeable. In this work, a low-content Ni-functionalized approach triggers the high capability of black phosphorene (BP) with hydrogen and oxygen evolution reaction (HER/OER) bifunctionality. Through a facile in situ electro-exfoliation route, the ionized Ni sites are covalently functionalized in BP nanosheets with electron redistribution and controllable metal contents. It is found that the as-fabricated Ni-BP electrocatalysts can drive the water splitting with much enhanced HER and OER activities. In 1.0 M KOH electrolyte, the optimized 1.5 wt% Ni-functionalized BP nanosheets have readily achieved low overpotentials of 136 mV for HER and 230 mV for OER at 10 mA cm−2. Moreover, the covalently bonding between Ni and P has also strengthened the catalytic stability of the Ni-functionalized BP electrocatalyst, stably delivering the overall water splitting for 50 h at 20 mA cm−2. Theoretical calculations have revealed that Ni–P covalent binding can regulate the electronic structure and optimize the reaction energy barrier to improve the catalytic activity effectively. This work confirms that Ni-functionalized BP is a suitable candidate for electrocatalytic overall water splitting, and provides effective strategies for constructing metal-lightweighted economic electrocatalysts.
Ethical AI governance: mapping a research ecosystem
Authors: Knight Simon , Shibani Antonette , Vincent Nicole 
Published: February 2024

AbstractHow do we assess the positive and negative impacts of research about- or research that employs artificial intelligence (AI), and how adequate are existing research governance frameworks for these ends? That concern has seen significant recent attention, with various calls for change, and a plethora of emerging guideline documents across sectors. However, it is not clear what kinds of issues are expressed in research ethics with or on AI at present, nor how resources are drawn on in this process to support the navigation of ethical issues. Research Ethics Committees (RECs) have a well-established history in ethics governance, but there have been concerns about their capacity to adequately govern AI research. However, no study to date has examined the ways that AI-related projects engage with the ethics ecosystem, or its adequacy for this context. This paper analysed a single institution’s ethics applications for research related to AI, applying a socio-material lens to their analysis. Our novel methodology provides an approach to understanding ethics ecosystems across institutions. Our results suggest that existing REC models can effectively support consideration of ethical issues in AI research, we thus propose that any new materials should be embedded in this existing well-established ecosystem.
TAI-PRM: trustworthy AI—project risk management framework towards Industry 5.0
Authors: Vyhmeister Eduardo , Castane Gabriel G. 
Published: February 2024

AbstractArtificial Intelligence (AI) is increasingly being used in manufacturing to automate tasks and process data, leading to what has been termed Industry. 4.0. However, as we move towards Industry 5.0, there is a need to incorporate societal and human-centric dimensions into the development and deployment of AI software artefacts. This requires blending ethical considerations with existing practices and standards. To address this need, the TAI-PRM framework has been developed. It builds upon established methods, such as Failure Mode and Effect Analysis (FMEA) and the Industrial ISO 31000, to manage risks associated with AI artefacts in the manufacturing sector. The framework identifies ethical considerations as hazards that can impact system processes and sustainability and provides tools and metrics to manage these risks. To validate the framework, it was applied in an EU project for Digital Twins on AI for manufacturing. The results showed that TAI-PRM can effectively identify and track different failure modes associated with AI artefacts and help users to manage ethical risks associated with their deployment. By incorporating ethical considerations into risk management processes, the framework enables the developing and deploying trustworthy AI in the manufacturing sector.
Enabling brief assessments of alexithymia: psychometric properties of the Russian version of the Perth Alexithymia Questionnaire-Short Form (PAQ-S) and its correlates with ill-being and well-being
Authors: Larionow Paweł , Preece David A. , Iakovleva Maria V. , Scherba Ekaterina K. 
Published: February 2024

AbstractAlexithymia is a trait involving deficits in emotion processing. As an important risk factor for a wide range of psychopathologies, its assessment is important in both research and clinical practice. Originally developed in English, the Perth Alexithymia Questionnaire-Short Form (PAQ-S) is a 6-item self-report measure of alexithymia, with its brevity designed to enable alexithymia assessments in a wide range of settings. In the present research, we aimed to introduce the first Russian version of the PAQ-S and examine its psychometric properties. Our sample consisted of 203 Russian-speaking adults aged 18–74 years, recruited from the general community in Russia. The PAQ-S’s factor structure was verified with confirmatory factor analysis. Convergent and divergent validity was assessed via relationships with psychopathology symptoms and well-being. Internal consistency reliability was evaluated. The Russian version of the PAQ-S demonstrated strong factorial validity, with support for the intended 1-factor structure as an overall marker of alexithymia. The PAQ-S total scale score showed good internal consistency reliability. As expected, its convergent and divergent validity was also supported. PAQ-S scores were significant predictors of higher ill-being (anxiety, depression, and stress) and lower well-being, thus demonstrating the high clinical relevance of the alexithymia construct as measured by the PAQ-S. There were no gender differences in PAQ-S scores, and alexithymia was higher in younger people and those with less education. Overall, the Russian PAQ-S therefore demonstrated strong psychometric properties as a brief and robust measure of overall alexithymia, performing similarly to other language versions.
Strategies for Enhancing Economic Sustainability: Modeling Reduced Bale Handling Costs in Cotton Warehousing
Authors: Richard Jessica , DeVuyst Eric A. , Kenkel Philip , Radmehr Reza 
Published: February 2024

AbstractCotton warehouses face unique inventory management challenges. This research addresses this challenge by proposing innovative strategies to enhance warehouse efficiency. Three key objectives are addressed: modeling cotton bale movements, evaluating an alternative to the current bale handling process, and evaluating an alternative to the current cotton bale marketing system. Results reveal significant cost savings. Changing bale receiving and placement strategy by using gin codes yields a $499,000 per-cycle reduction for an Oklahoma cotton warehouse case. Altering order fulfillment techniques, such as grouping 30 orders, saves $34,000 per cycle. Implementing quality-based bale substitution leads to a $1.3 million saving per cycle.