bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing mixed sample analysis as a step to comprehensive desease screening: a pilot study
Authors: Krasnicanova Lucia , Forgacova Natalia , Sedlackova Tatiana , Budis Jaroslav , Gazdarica Juraj , Repiska Vanda , Szemes Tomas 
Published: November 2023

AbstractBackgroundLynch Syndrome (LS) is an autosomal dominant hereditary syndrome associated with a diverse range of cancer types. Despite being one of the most prevalent hereditary cancer syndromes, the detection of LS remains challenging due to the absence of well-defined diagnostic criteria which would be able to select all patients who should undergo testing for LS and the limitations of existing screening methods. The implementation of an efficient screening program capable of accurately detecting the majority of LS cases remains a topic of continuous discussion in the scientific literature, with recent studies emphasizing the significance of a universal screening program.MethodsOur study aimed to develop and optimize a cost-effective universal screening method for detecting mutation in the mismatch repair (MMR) genes through mixed sample analysis. We tested five approaches in terms of the use of biological material and the analysis of mixed samples.ResultsEach approach successfully detected a specific Lynch-associated pathogenic variant in mixed in the pooled samples with frequency 5.00%, with the lowest allelic fraction recorded at 3.04%. Approach 2, which involved isolating DNA from each patient individually, demonstrated the highest average allelic fraction (7.04%). However, considering financial and time requirements, approach 1, where DNA was isolated only after mixing aliquots of whole blood, proved to be the most favorable.ConclusionThe findings of our study present a promising opportunity to improve LS detection. The identification of LS not only has the potential to prevent cancer-related morbidity and mortality but also facilitates continued progress in understanding the primary prevention of cancer.
Do audit attributes impact earnings quality? Evidence from India
Authors: Verma Deepak , Dawar Varun , Chaudhary Pankaj 
Published: November 2023

PurposeThe present study's goal is to analyze the impact of audit quality (AQ) on earnings quality (EQ) using different audit attributes. The study shows empirical evidence from India, considered an emerging market.Design/methodology/approachThe sample selected represents the 376 non-financial firms listed on the Bombay Stock Exchange (BSE). With a 20-year time frame, the authors used the absolute value of discretionary accruals (McNichols, 2002) (DA) as a proxy for EM, which is inversely related to EQ. The authors analyzed data using OLS, fixed effect (FE), 2SLS and Panel-IV estimators.FindingsThe authors found that most audit attributes positively affect EQ. In the Indian context, joint auditor (JA), auditor size (A_SIZE), auditor fee (A_FEE) and auditor tenure (A_TENURE) have a negative association with EM indicating high EQ. In contrast, auditor rotation (A_ROTATON) positively affects EM confirming low EQ.Research limitations/implicationsThe present study uses Big-4 and its member firms as a proxy of auditor size (A_SIZE); instead, other bases may be taken for it, like the dominant audit firms in a particular industry in sample data, etc. The authors have started audit tenure from the base year, i.e. 2001, which may ignore the association of auditor and auditee just before 2001.Practical implicationsThe study findings would enhance policymakers' willingness to prepare appropriate regulations regarding JAs and auditor rotation, which might improve financial market efficiency and reduce financial fraud among Indian corporates.Originality/valueTo the best of the authors' knowledge, this is the first study to incorporate “Joint Auditor” (JA) as a proxy for audit quality in the Indian context, which might significantly contribute to the literature.
Blockchain technology in foreign trade management: which blockchain alternative is more suitable?
Authors: Topcu Yunus Emre , Can İbrahim Enes , Özçınar Atilla 
Published: November 2023

Purpose
This study aims to determine the order of importance of blockchain technology gains for foreign trade management. The second aim of the research is to select the most suitable blockchain type for the foreign trade process.

Design/methodology/approach
The data required for the research analysis were collected through comparison matrices scored by foreign trade experts. The data were analyzed with the analytical hierarchy process method, and the gains of blockchain technology for the foreign trade process were prioritized. Finally, the most suitable type of blockchain technology was selected with the PROMETHEE method.

Findings
As a result of the study, subject matter experts perceived that the most critical blockchain gain for the foreign trade process would be cost savings. In addition, it has been observed that the general trade process differs compared to the logistics and payment processes. Finally, open blockchain was the most suitable blockchain type for foreign trade processes.

Research limitations/implications
In this study, the positive gains of blockchain technology are considered. In future studies, it is recommended to consider the existing negative factors to be able to use blockchain technology in foreign trade processes. In addition, it is suggested to conduct a study by dividing foreign trade into two, import and export.

Practical implications
All stakeholders who want to integrate blockchain technology into their foreign trade processes, including foreign trade companies, software developers, policymakers and international institutions, can benefit from the results of this study. A blockchain technology software created for foreign trade management can be shaped according to the results of this study.

Originality/value
Although the gains that blockchain technology provides to foreign trade processes are frequently emphasized in the literature, which gain would be greater has not been examined. The lack of an answer to the issue of how blockchain technology should be designed for foreign trade processes has been the missing part of the relevant literature. To the best of the authors’ knowledge, this study is the first experimental study in the literature that prioritizes blockchain gains and selects the appropriate blockchain type for foreign trade processes.
Aerodynamic optimization of mixed platoon Ahmed body vehicles based on response surface method
Authors: Luo Jianbin , Tie Yuanhao , Mi Ke , Pan Yajuan , Tang Lifei , Li Yuan , Xu Hongxiang , Liu Zhonghang , Li Mingsen , Jiang Chunmei 
Published: November 2023

Purpose
The purpose of this paper is to investigate the optimal average drag coefficient of the Ahmed body for mixed platoon driving under crosswind and no crosswind conditions using the response surface optimization method. This study has extraordinary implications for the planning of future intelligent transportation.

Design/methodology/approach
First, the single vehicle and vehicle platoon models are validated. Second, the configuration with the lowest average drag coefficient under the two conditions is obtained by response surface optimization. At the same time, the aerodynamic characteristics of the mixed platoon driving under different conditions are also analyzed.

Findings
The configuration with the lowest average drag coefficient under no crosswind conditions is 0.3 L for longitudinal spacing and 0.8 W for lateral spacing, with an average drag coefficient of 0.1931. The configuration with the lowest average drag coefficient under crosswind conditions is 10° for yaw angle, 0.25 L for longitudinal spacing, and 0.8 W for lateral spacing, with an average drag coefficient of 0.2251. Compared to the single vehicle, the average drag coefficients for the two conditions are reduced by 25.1% and 41.3%, respectively.

Originality/value
This paper investigates the lowest average drag coefficient for mixed platoon driving under no crosswind and crosswind conditions using a response surface optimization method. The computational fluid dynamics (CFD) results of single vehicle and vehicle platoon are compared and verified with the experimental results to ensure the reliability of this study. The research results provide theoretical reference and guidance for the planning of intelligent transportation.
The human consequences of economic sanctions
Authors: Rodríguez Francisco 
Published: November 2023

PurposeThe use of economic sanctions has grown dramatically in recent decades. Nevertheless, many arguments are presented in the public policy space regarding their effects on target populations. The author presents the first systematic analysis of the effects of sanctions on living conditions in target countries.Design/methodology/approachThis paper provides a comprehensive survey and assessment of the literature on the effects of economic sanctions on living standards in target countries. The author identifies 31 studies that apply quantitative econometric or calibration methods to cross-country and national data to assess the impact of economic sanctions on indicators of human and economic development. The author provides in-depth discussions of three sanctions episodes—Iran, Afghanistan and Venezuela—that illustrate the channels through which sanctions affect living conditions in target countries.FindingsOf the 31 studies, 30 find that sanctions have negative effects on outcomes ranging from per capita income to poverty, inequality, mortality and human rights. The author provides new results showing that 54 countries—27% of all countries and 29% of the world economy— are sanctioned today, up from only 4% of countries in the 1960s. In the three cases discussed, sanctions that restricted the access of governments to foreign exchange limited the ability of states to provide essential public goods and services and generated substantial negative spillovers on private sector and nongovernmental actors.Originality/valueThis is the first literature survey that systematically assesses the quantitative evidence on the effect of sanctions on living conditions in target countries.
Trade effects of liner shipping across world regions
Authors: Del Rosal Ignacio 
Published: November 2023

Purpose Liner shipping plays a crucial role in facilitating the movement of manufactured goods around the world. While previous literature has shown that liner shipping is an important trade driver, potential differences across trade routes and world regions have not as yet been explored. This paper examines whether the impact of liner shipping on bilateral trade flows differs significantly across world regions, as well as exploring other geographical patterns.Design/methodology/approach Using state-of-the-art gravity modelling, this paper investigates the impact of the UNCTAD's Liner Shipping Bilateral Connectivity Index on bilateral trade in manufactured goods using a comprehensive database of disaggregated trade data for the period from 2006 to 2019.Findings The results show that the trade effect of liner shipping is greater in long-distance and interregional bilateral flows. For some regions, such as North America and Oceania, the effect is greater than the world average, while for others, such as Africa and South America, the effect is significantly smaller. The trade effects of liner shipping connectivity on the main east–west routes are average, but clear asymmetry emerges when analysing China's inward and outward trade flows separately.Originality/value The results of this paper show that the major east–west routes determine the baseline trade effects of liner shipping, demonstrate that some north–south trades such as those involving Oceania generate larger trade effects and confirm that the trade effects of liner shipping can be improved for some world regions such as South America and Africa.
Leadership and managerial challenges to ensure agile management as a method to enable business success: a Delphi study of the Slovenian health organisations
Authors: Roblek Vasja , Dimovski Vlado , Jovanov Oblak Kristjan , Meško Maja , Peterlin Judita 
Published: November 2023

Purpose
This study aims to apply the Delphi method to explore the possibilities for implementing agility management concepts in Slovenian health-care organisations.

Design/methodology/approach
The research is based on a qualitative Delphi study encompassing 15 employees in different Slovenian health-care organisations.

Findings
Slovenian health-care organisations need to be more agile currently. For this reason, it is necessary to begin with organisational changes and organisational learning concepts to educate employees about the meaning and content of agile processes. It is essential to ensure that accepting employee mistakes and offering help to employees becomes normal practice, and it is necessary to ensure the greater trust of the management towards the employees.

Originality/value
The research empowers health-care professionals with new management and leadership concepts, such as agile management, sustainable leadership and leadership development methods in health care.
Fintech development and environmental sustainability: Does income inequality matter?
Authors: Vu Nam Thanh , Bui Hung Quang , Pham Tuan Anh , Vo Duc Hong 
Published: November 2023

AbstractThis paper investigates whether and how fintech development is associated with environmental quality. A machine learning technique—the principal component analysis (PCA), is adopted to construct an index that measures fintech development. The two‐step system generalised method of moments (GMM) addresses the potential endogeneity in the established nexus. Analysing a panel of 42 countries from 2012 to 2021, we found that fintech development can improve environmental quality by encouraging low‐carbon energy consumption and mitigating anthropogenic polluting emissions. Our analysis further reveals that high‐income inequality, a socioeconomic issue, counteracts the favourable features of fintech development on the environment. Our findings are robust across various additional analyses and environmental quality indicators. This study, therefore, contributes to the scarce but growing literature on the fintech‐environment nexus.
Financial Analyst Coverage and Corporate Environmental Disclosure
Authors: Benlemlih Mohammed , Bitar Mohammad , Ouadghiri Imane El , Peillex Jonathan 
Published: November 2023

AbstractConsistent with the monitoring function played by financial analysts, we find that greater analyst coverage leads to the same extent of improvement in the quantity and quality of environmental information disclosed by the firm. This result is remarkably robust after conducting a difference‐in‐differences analysis that exploits brokerage closures and mergers as an exogenous decrease in analyst coverage, as well as using an instrumental variable approach. The positive influence of analyst coverage on corporate environmental disclosure is particularly evident for firms that cause high environmental damage, firms with low information asymmetry and those followed by analysts with superior experience, accuracy and reputation. Taken together, our empirical findings provide new insights into the bright side effect of analyst coverage on corporate environmental‐related activities.
The effect of hand fine motor skills on peritoneal dialysis‐related peritonitis
Authors: Dogan Ibrahim , Ucar Emel , Odabas Mehtap , Kaya Nur Unal , Sadioglu Rezzan Eren , Celik Gulden , Acikgoz Elif , Sayarlioglu Hayriye , Turkmen Ercan , Delibalta Bulbul , Aktas Nimet , Cakir Selma Kuran , Kaya Emel Acar , Alsancak Serap , Ayar Yavuz , Ustunel Narin , Inan Zuhal , Yildirim Tolga , Sen Fatma , Oruc Aysegul , Korkmaz Rahime , Kayadibi Huseyin , Ates Kenan 
Published: November 2023

AbstractIntroductionWe aimed to evaluate the relationship between the hand fine motor skills of peritoneal dialysis (PD) practitioners and PD‐related peritonitis.MethodsThis multicenter prospective observational study was conducted with 120 incident PD patients. Patients were divided into two groups who had PD‐related peritonitis within the first year as Group 1, and those who did not as Group 2. Hand fine motor skills were evaluated by Nine‐Hole Peg Test (NHPT) and Nut Screwing Test (NST).ResultsInitial NHPT (28.5 ± 6.0 s vs. 25.8 ± 5.0 s, p = 0.011) and NST (82.3 (61.5–102.8) s versus 65.3 (52.3–88.5) s p = 0.023) scores were significantly higher in Group 1 than Group 2. In multivariate logistic regression analysis, NHPT, Body Mass Index, Mini‐Mental Test, self PD practitioner, and catheter complications were found to be independent variables in predicting PD‐related peritonitis.ConclusionDecreased hand fine motor skills of PD patients is a risk factor for peritonitis.
Peripheral nerve blocks for closed reduction of distal radius fractures—A protocol for a systematic review
Authors: Pisljagic Sanja , Temberg Jens L. , Steensbæk Mathias T. , Yousef Sina , Maagaard Mathias , Chafranska Lana , Lange Kai H. W. , Rothe Christian , Lundstrøm Lars H. , Nørskov Anders K. 
Published: November 2023

AbstractBackgroundCurrent methods of anaesthesia used for closed reduction of distal radial fractures may be insufficient for pain relief and muscle relaxation, potentially compromising reduction quality and patient satisfaction. Peripheral nerve blocks have already been implemented for surgery of wrist fractures and may provide optimal conditions for closed reduction due to complete motor and sensory blockade of the involved nerves. However, existing literature on peripheral nerve blocks for closed reduction is sparse, and no updated systematic review or meta‐analysis exists.AimsThis protocol is developed according to the PRISMA‐P statement. The systematic review and meta‐analysis aim to consolidate the literature regarding the effect and harm of peripheral nerve blocks compared with other anaesthesia modalities for closed reduction of distal radius fractures in adults.MethodsThe two primary outcomes are the proportion of participants needing surgery after closed reduction and pain during closed reduction. We will only include randomised clinical trials. Two review authors will each independently screen literature, extract data, and assess risk of bias with Risk of Bias 2 Tool. Meta‐analysis will be carried out with Rstudio. We will also perform a Trial Sequential Analysis. The certainty of evidence will be judged using GRADE guidelines.DiscussionWe will use up‐to‐date methodology when conducting the systematic review outlined in this protocol. The results may guide clinicians in their decision‐making regarding the use of anaesthesia for closed reduction of distal radius fractures in adults.
Population size and social structure of lions in a west African protected area
Authors: Gueye Malle , Pellaton Raoul , Van Cauteren Dorien , Mengual Lisa , Van Dongen Stefan , Leirs Herwig , Bertola Laura D. , Faye Papa Mor , Diop Babacar , Diop Maniang Mamadoune , Kanté Abdoulaye , de Iongh Hans 
Published: November 2023

AbstractTo inform the conservation of the Regionally Critically Endangered West African lion, we studied lion population size and social structure in Niokolo Koba National Park (NKNP), Senegal. Calling station and camera trap surveys were conducted and opportunistic lion observations were documented from 2015 to 2020. The average lion density was calculated as 0.50 lion/100 km2 and the population size was estimated as 28–56 individuals. Average lion group size was 2.1 ± 1.45 lions (range 1–8 lions). There were no significant differences between observations of single individuals (43%), groups of two (22%), three (19%), four (4%) and more than four (5%) individual lions (X2 = 30.021, p‐value = 0.06452). Sex ratio showed a ratio of male:female of 1:1.1 to 1:2.8. About 13.59% of the lion population was composed of cubs while, respectively, 81.22% and 5.17% were adults and subadults. Based on the analysis of activity patterns, lions in NKNP are mainly nocturno‐crepuscular (18:00–01:00) and matutinal (06:00–08:00). Lion population size and density are still low in NKNP compared to earlier estimates from the same area, in the late 1990s. We therefore conclude that the conservation of lions in NKNP must be further improved to safeguard this population in the long term.
From clinical findings to the pathomechanism of poikiloderma with neutropenia
Authors: Larizza Lidia 
Published: November 2023

The clinical problem of a non‐healing fistula in ano in a child affected with poikiloderma with neutropenia (PN) was the stimulus for an innovative study by Parajuli et al. that sheds light on the pathological mechanisms in this disease. Multiparametric analyses of the patient's blood mononuclear cells by cell culture, flow cytometry and multiplex cytokine assay suggested a block of monocyte differentiation. Monocyte transcriptome profiling revealed a signature consistent with the haematological picture and the clinical presentation.Commentary on: Parajuli et al. Defective monocyte plasticity and altered cAMP pathway characterize USB1‐mutated poikiloderma with neutropenia Clericuzio type. Br J Haematol 2024;204:683‐693.
Interdisciplinary variations of metadiscursive verb patterns in English research articles
Authors: Chen Songyun , Xu Jiajin 
Published: November 2023

AbstractThe widespread use of metadiscourse is vital to the study of academic discourse and genre analysis. This article focuses on the concept of metadiscursive verb patterns (MVPs) and examines their variation in English research articles across four domains representing hard/soft‐pure and hard/soft‐applied disciplines. Based on a bottom‐up investigation of a self‐compiled corpus, three findings are highlighted: (1) the crucial rhetorical roles of MVPs were established by their distinct functions in knowledge construction; (2) significant interdisciplinary variations of MVPs reflected the typical written conventions shared by writers of different disciplinary communities; and (3) the association between (sub‐)categories of MVPs and disciplines foregrounded the most popular rhetorical strategies for using MVPs and salient disciplinary features. These findings are discussed in terms of the factors governing the use of MVPs and identification of disciplinary boundaries. Pedagogical considerations for understanding MVPs and proper rhetorical strategies for using these tools are discussed.
Fluorescence and temperature sensing properties of Zr4+ and Er3+ codoped Y2O3 prepared by laser annealing
Authors: Zhao Shuai , Deng Yawen , Yang Yan , Lin Jiahao , He Yaru , Gong Jing , Huang Lei , Dang Suihu , Bai Yunfeng 
Published: November 2023

AbstractY2O3 codoped with different Zr4+ (10% mol, 30% mol, and 49% mol) and constant Er3+ (2% mol) ions were successfully prepared via the laser annealing method. According to the XRD data, the lattice parameters decrease with the increase of Zr4+, and the grain size increases with Zr4+. The crystal space group switches from Ia‐3 to Fm‐3 m at a Zr4+ concentration of 49% mol. As the concentration of doped Zr4+ increases, the upconversion emission of Er3+ decreases. The nonequivalent substitution of Y3+ by Zr4+ creates lattice defects, which affect the fluorescence intensity of Er3+ ions in the material. The temperature sensing behavior of Y88%Zr10%Er2%O1.55 crystals based on the fluorescence intensity ratio between 4S3/2→4I15/2 and 4I9/2→4I15/2 transitions of Er3+ is studied. The results show that after codoping with Zr4+, the 4S3/2→4I15/2 and 4I9/2→4I15/2 transitions satisfy the Boltzmann distribution formula at temperatures above 333K. And the temperature sensing relative sensitivity can reach 2.96%K−1.