bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the prognostic necroptosis-related genes and underlying mechanism in sepsis using bioinformatics
Authors: Liu Jie , Li Lin , He Shuyang , Zheng Xin , Zhu Dan , Kong Guangyao , Li Ping 
Published: October 2023

Abstract
Sepsis is a life-threatening disease due to a dysregulated host response to infection, with an unknown regulatory mechanism for prognostic necroptosis-related genes (NRGs). Using GEO datasets GSE65682 and GSE134347, we identified six NRG biomarkers (ATRX, TSC1, CD40, BACH2, BCL2, and LEF1) with survival and diagnostic significance through Kaplan-Meier (KM) and ROC analyses. The ingenuity pathway analysis (IPA) highlighted enrichment in hepatic fibrosis pathways and BEX2 protein. We examined their regulatory targets and functional links with necroptotic signaling molecules via miRDB, TargetScan, Network analyst, and GeneMANIA. Hsa-miR-5195-3p and hsa-miR-145-5p regulated ATRX, BACH2, and CD40, while TF YY1 showed strong connectivity, concurrently controlling LEF1, ATRX, BCL2, BACH2, and CD40. CD40 exhibited similar expression patterns to RIPK3 and MLKL, and LEF1 was functionally associated with MLKL. Additionally, DrugBank analysis identified Paclitaxel, Docetaxel, and Rasagiline as potential BCL2-targeting sepsis treatments. Real-Time Quantitative PCR confirmed ATRX, TSC1, and LEF1 down-regulation in sepsis samples, contrasting CD40's increased expression in case samples. Variations in BACH2 and BCL2 expression between disease and normal samples may result from sample differences. In conclusion, ATRX, TSC1, CD40, BACH2, BCL2, and LEF1 may be critical regulatory targets of necroptosis in sepsis, providing a basis for further necroptosis-related studies in sepsis.
Causal relationship between Hypertrophic Cardiomyopathy and Psychiatric Disorders: a two-sample Mendelian randomization
Authors: Wang Kuangyi , jiang yufeng , Zhou Yafeng 
Published: October 2023

Abstract
Background
Hypertrophic cardiomyopathy (HCM) is a prevalent genetic cardiovascular disease associated with increased arrhythmia and sudden death risk, especially in young individuals. Mental disorders, such as epilepsy, schizophrenia, Alzheimer's Disease, Parkinson's Disease, and depression, are also influenced by genetic factors. Our study utilizes Mendelian Randomization (MR) to investigate the causal relationship between hypertrophic cardiomyopathy and these mental disorders, shedding light on potential pathogenic links and disease risks. This MR-based analysis offers a novel perspective in exploring these connections.
Methods
We employed a comprehensive approach to select genetic instrumental variables for hypertrophic cardiomyopathy (HCM), epilepsy, schizophrenia, Alzheimer's Disease, Parkinson's Disease, and depression from different databases. Subsequently, a two-sample Mendelian randomization (MR) analysis was conducted to evaluate causal relationships between HCM and the five psychiatric disorders. We applied appropriate methods based on heterogeneity, including Cochran's Q test and fixed-effects Inverse Variance Weighted (IVW) method. Sensitivity analysis, the maximum likelihood method, was employed to assess causality robustness. Directional pleiotropy was evaluated using the MR-Egger method, and the "leave-one-out" method was applied to gauge individual SNP influence.
Results
Our analysis identified a promoting effect of depression (fixed effects IVW: p-value = 0.0031, OR = 1.0044, 95% CI=(1.0015, 1.0073)) on HCM. Sensitivity analyses confirmed the reliability of our findings, with no significant heterogeneity or horizontal pleiotropy detected.
THE ROMANS ON THE BARBARIANS MORALS (I C. B.C. – IV C.A.D.)
Authors: ЕРМОЛОВА И.Е. 
Published: October 2023

Целью главы является исследование римских письменных сочинений о внешних племенах, чтобы попытаться понять, всегда ли реальность, сконструированная средствами языка, была тождественна самой реальности как последовательности фактов, событий, явлений. Все другие народы древние греки называли варварами. Они и древние римляне относились к ним свысока, с чувством превосходства. Со временем в античной литературе сформировался стереотипный образ варвара, вне зависимости от того, о каком конкретном племени идет речь, который передавался из поколения в поколение. Римские авторы внесли значительный вклад в создание портрета варвара, главным образом, негативного. В своих сочинениях они акцентировали внимание слушателей и читателей на дикости, грубости, свирепости, жестокости, алчности и других отрицательных чертах представителей различных племен, с которыми контактировала Римская империя, таким образом, успешно манипулируя общественным мнением, вызывая страх и презрение к ним, а также провоцируя по отношению к ним жестокость и варварское насилие.
The purpose of the chapter is to study the Roman written writings about external tribes in order to try to understand whether reality constructed by means of language was always identical to reality itself as a sequence of facts, events, phenomena. The ancient Greeks called all other peoples barbarians. They and the ancient Romans treated them haughtily, with a sense of superiority. Over time, a stereotypical image of a barbarian was formed in ancient literature, regardless of which particular tribe it was about, which was passed down from generation to generation. Roman authors made a significant contribution to the creation of a portrait of the barbarian, mainly negative. In their writings, they focused the attention of listeners and readers on savagery, rudeness, ferocity, cruelty, greed and other negative traits of representatives of various tribes with whom the Roman Empire was in contact, thus successfully manipulating public opinion, causing fear and contempt for them, as well as provoking cruelty and barbaric violence against them.
«A NAME AND A BAD NAME ARE THE SAME»: NICKNAMES AND INSULTS OF ANCIENT AND MODERN ATHLETES
Authors: СЕЛИВАНОВА Л.Л. 
Published: October 2023

Наш стремительно развивающийся мир является свидетелем возрождения, казалось бы, давно забытого варварства. Восстав из пепла, оно пронизывает все области коммуникации, включая язык. Вербальное варварство наиболее ярко проявляется в таких брутальных сферах общественной деятельности, как война и спорт, где враг / соперник унижается не только делом, но словом. Корни этого варварского поведения уходят в античность, где и возник атлетизм, предшественник современного спорта. В главе анализируются причины возникновения в языке цивилизованных греков и римлян прозвищ, словесных оскорблений атлетов, грубости и насмешек в их адрес, и приводятся сопоставления с аналогичной ситуацией в современном спорте. Среди прочих тем поднимается вопрос о том, какую опасность представляло и продолжает представлять словесное варварство. Автор приходит к выводу, что это явление возникло в античности вследствие политического кризиса и размывания традиционной системы ценностей после победы демократии над аристократией. Возродившись в конце XIX в., современные Олимпийские игры, несмотря на романтические настроения их инициатора, барона Пьера де Кубертена, пошли по пути античного атлетизма периода упадка и деградации.
Our rapidly developing world is witnessing the revival of a seemingly long-forgotten barbarism. Rising from the ashes, it permeates all spheres of social activities, including language. Verbal barbarity reveals itself most visibly in such brutal spheres of social activities as war and sports, which aim to dominate the opponent not only physically but verbally as well. The roots of this barbaric behavior go back to antiquity, which was the cradle of athleticism and the precursor of modern sports. The chapter analyzes the reasons why the language of the civilized Greeks and Romans included bad nicknames, verbal insults of athletes, rudeness and ridicule in their address, and adduces comparisons with a similar situation in modern sports. Among other topics, it raises the question of what kind of danger was and is still being posed by verbal barbarity. The author concludes that this phenomenon emerged in antiquity as a consequence of a political crisis and a dilution of the traditional system of values after the victory of democracy over aristocracy. Having been revived in the late 19th century, the modern Olympic games, despite the romantic sentiment of their initiator, Baron Pierre de Coubertin, have followed ancient athleticism’s path of the period of decay and degradation.
BARBARIC DEEDS AND WORDS: ALEXANDER OF MACEDON AND ARISTON OF PAEONIF ON THE BANKS OF THE TIGRIS
Authors: КЛЕЙМЕНОВ А.А. 
Published: October 2023

Цель исследования заключается в анализе культурно-ментальных аспектов взаимодействия пеонийского командира Аристона и Александра Великого после кавалерийского боя у реки Тигр. Задачами являются определение обстоятельств и значения столкновения македонской и персидской конницы, рассмотрение действий Аристона в контексте особенностей ценностных установок военной элиты балканских варварских сообществ, выявление связи реакции Александра на поведение Аристона с традициями, характерными для Македонии времен Аргеадов. Исследование опиралось на всесторонний анализ письменных источников, сравнительно-исторический метод, метод контент-анализа. Определено, что в сентябре 331 г. до н.э. после переправы македонского войска через реку Тигр имел место бой смешанного отряда кавалерии Александра и 1 000 персидских всадников, в итоге которого персы были рассеяны. Особо отличился предводитель подразделения пеонийских всадников Аристон, убивший командира персов и принесший его отрубленную голову Александру, высказав желание получить за это золотую чашу. Подобные действия соответствовали воинским традициям пеонов и других балканских варваров. Александр согласился исполнить желание Аристона, а также сообщил о намерении выпить за здоровье пеонийского предводителя несмешанного вина. Определяется, что этим полководец показал, что как представитель македонской военной элиты понимает и разделяет ценностные установки балканского героического этоса.
The main aim of the research is the analysis of cultural and mental aspects of Paeonian commander Ariston and Alexander the Great after the cavalry battle by the river Tigris. The targets of the research are determination of the circumstances and significance of the collision of the Macedonian and Persian cavalry, consideration of Ariston’s action in the context of the features of value attitudes the military elite of the Balkan barbaric societies’ identification of Alexander’s reaction connection on Ariston’s behavior with traditions characteristic of Argead Macedonia. A multi-faceted approach to the ancient narrative sources, methods of comparative historical analysis and content analysis have been used. It is defended that in September 331 BC after the crossing the river Tigris of the Macedonian army there was a battle of a mixed detachment of cavalry of Alexander and 1,000 Persian horsemen. As a result of the battle, the Persians were scattered. Especially distinguished himself the commander of the Paeonian cavalry Ariston, who killed the leader of the Persians and brought his severed head to Alexander. Ariston expressed a desire to receive a gold cup for this. Such actions corresponded to the military traditions of the Paeonians and others Balkan barbarians. Alexander agreed to fulfill Ariston’s wish, and also announced his intention to drink to health Paeonian commander unmixed wine. It is defended that in this way the commander showed that as a representative of the Macedonian military elite he understood and shared values of the Balkan heroic ethos.
FROM WORD TO ACTION: VERBAL AND PHYSICAL BARBARISM AS AN INDICATOR OF A CIVILIZED SOCIETY
Authors: КУЗЬМИНА М.В. 
Published: October 2023

Глава посвящена проблеме вербального и физического варварства — форм варварского поведения на материале средневекового общества (Франция, XIV–XV вв.). Варварство как эквивалент неподобающего, грубого, жестокого отношения людей друг к другу противостоит цивилизованности — одного из признаков цивилизованного общества и является, по сути, индикатором, показывающим, можно ли говорить и в какой мере о том, насколько варварское присутствует в поведении как отдельных индивидов, так и в межличностных отношениях в данном конкретном обществе в целом. Варварство — неотъемлемая часть поведенческих характеристик людей, живущих в цивилизованном обществе (в одних оно проявляется более ярко, в других — вытесняется на периферию социальной жизни, но никогда не исчезает). Цивилизованность общества определяется не наличием таких элементов, а тем, как данное общество нивелирует их, контролируя соблюдение приоритетных моральноэтических норм, жёстко наказывая за наиболее опасные проявления и более щадяще — за менее опасные, с точки зрения сохранения социального мира, менее вредоносные.
The chapter is devoted to the problem of verbal and physical barbarism — forms of barbarian behavior on the material of medieval society (France, XVI–XV centuries). Barbarism as the equivalent. of an inappropriate, rude, cruel attitude of people towards each other opposes civility — one of the signs of a civilized society and is, in fact, an indicator showing whether and to what extent it is possible to speak about how barbaric is present in the behavior of individuals, and in interpersonal relations in this particular society as a whole. Barbarism is an integral part of the behavioral characteristics of people living in a civilized society (in some it manifests itself more clearly, in others it is forced out to the periphery of social life, but never disappears), however, the civility of a society is determined not by the presence of such elements, but by how a given society levels them, resorting, among other things, to monitoring compliance with priority moral and ethical norms, severely punishing the most dangerous manifestations and more sparingly — for less dangerous from the point of view of maintaining social peace, less harmful.
CONTEMPORARY DISCOURSE ON THE ORIGINS OF THE BRETONS: TENDENCIES OF CELTOSKEPTICISM
Authors: ЛЮБАРТ М.К. 
Published: October 2023

На протяжении более двух столетий идея о том, что бретонцы являются кельтским по происхождению народом, являлась общепризнанной. Отсылки к кельтской истории и культуре являются одной из значимых составляющих (этно)культурной идентичности бретонцев, которая укреплялась на протяжении долгого времени под влиянием высокого интереса к древней и загадочной культуре кельтов, — кельтомании. Однако новые данные археологии и палеогенетики говорят о необходимости коррекции представлений о протоистории региона и начальных этапов этногенеза бретонцев, ставят под сомнение их кельтское происхождение. В этой главе анализируются современные тенденции кельтоскептицизма во французской науке и основные черты дискуссии в научном сообществе, развернувшейся в связи с этим.
For more than two centuries, the idea that the Bretons are of Celtic origin has been generally accepted. References to Celtic history and culture are one of the significant components of the (ethno) cultural identity of the Bretons, which has been strengthened over time under the influence of high interest in the ancient and mysterious culture of the Celts - Celtomania. However, new data from archeology and paleogenetics speak of the need to correct ideas about the protohistory of the region and the initial stages of the ethnogenesis of the Bretons, and cast doubt on their Celtic origin. This chapter analyzes the current trends of Celtoskepticism in French science and the main features of the discussion in the scientific community that unfolded in connection with this.
BASTARNAE: THE PROBLEM OF HISTORICAL AND ETHNOGRAPHIC IDENTIFICATION
Authors: ГУСАКОВ М.Г. 
Published: October 2023

Глава посвящена проблеме археологической и этнической принадлежности бастарнов, одного из племен европейского варварского мира конца I тысячелетия до н.э. Рассматриваются особенности участия бастарнов в миграционном движении племен на территории от Эльбы до Днепра. В предлагаемой вниманию читателей статье анализируется появление и исчезновение тех или иных археологических культур, представлена методика установления связей между ними, предложена типология историко-археологических сопоставлений. Анализируя эволюцию обряда погребения и особенность погребального инвентаря, автор приходит к заключению о правомерности ранее высказанного предположения (М.Б. Щукин) о принадлежности бастарнов к зарубинецкой культуре.
The chapter is devoted to the problem of the archaeological and ethnic identity of the Bastarnae, one of the tribes of the European barbarian world of the end of the I millennium BC. The features of the participation of Bastarnae in the migration movement of tribes on the territory from the Elbe to the Dnieper are considered. This article analyzes the appearance and disappearance of certain archaeological cultures, presents a methodology for establishing links between them, and suggests a typology of historical and archaeological comparisons. Analyzing the evolution of the burial rite and the peculiarity of the burial inventory, the author comes to the conclusion about the validity of the previously stated assumption (M.B. Shchukin) about the Bastarnae belonging to the Zarubinets culture.
POLITICAL DEFAMATION AND PUBLIC VIOLENCE AT THE MEROVINGIAN COURT IN THE LAST THIRD OF THE 6TH CENTURY
Authors: САЗОНОВА А.А. 
Published: October 2023

Глава посвящена изучению негативных проявлений в вербальной реальности и политической культуре меровингского общества последней трети VI в., которые в форме клеветы и диффамации запускали процедуру судебных разбирательств, становились триггерами для убийств и жестоких расправ. Нейстрийский двор Хильперика и Фредегонды стал ареной ожесточенной внутрисемейной борьбы за власть, где за словесным обманом последовала гибель двух принцев и королев. Проведенный анализ показал, что основными направлениями по политической дискредитации и физическому устранению личных врагов королевской четы из светской и церковной элиты стали обвинения в покушении на убийство короля с целью захвата королевской власти и преследование за колдовские преступления. Одним из выводов статьи стало обоснование синхронии и причинно-следственной связи между тремя этапами горевания Фредегонды по умершим сыновьям и пиковой агрессией расправ королевы с ее политическими врагами. Автор предлагает новые исследовательские интерпретации для известных исторических эпизодов из аутентичных источников.
The chapter is devoted to the study of negative manifestations in the verbal reality and political culture of the Merovingian society in the last third of the 6th century, which, in the form of slander and defamation, started the trial and inquiry, became triggers for murders and bloodthirsty violence. The Neustrian court of Chilperic and Fredegund became the scene of a fierce family struggle for power, where verbal deception led to the deaths of two princes and queens. The analysis showed that the main directions for political discrediting and execution of the personal enemies of the royal couple from the secular and church elite were accusations of attempt on life of the king in order to seize royal power and prosecution for witchcraft crimes. One of the conclusions of the article was the verification of the synchrony and causal relationship between the three stages of Fredegund’s grief for her dead sons and the peak aggression of the queen’s barbarian cruelty against her political enemies. New research interpretations of famous historical cases from authentic sources are proposed.
CONTRIBUIÇÕES DO ORE PARA O COMBATE À COVID-19 NOS CENTROS CIRÚRGICOS
Authors: Cavalcante dos Santos Barbara Emanuelle , Francis Souza Bezerra da Silva Mariane , Nery Vieira Lara Camila , Agra Pimentel Cristiane 
Published: October 2023

O presente artigo visa identificar as possíveis contribuições do indicador de eficiência ORE (Operating Room Effectiveness) para o combate à Covid-19. Foi empregado o método de pesquisa bibliográfica, analisando materiais existentes, e exploratória por se tratar de um estudo sobre um assunto de pouco conhecimento. Como resultados foram citados exemplos da aplicação do indicador ORE nos hospitais, e a importância do indicador está em conjunto com a filosofia Lean Healthcare, demonstrando a necessidade de melhorias na gestão dos Centros Cirúrgicos, contribuindo assim, para nesse momento de pandemia através da garantia da prestação dos serviços com qualidade, segurança e disponibilidade dos leitos. Colaborando também para a área financeira, pois alocando recursos ao que é necessário, evita desperdícios e proporciona lucros. E auxilia ainda para o conhecimento científico, visto que os resultados poderão servir de base para consulta em trabalhos futuros.
Palavras-chave: Centro Cirúrgico; Covid-19; ORE.
Assessment of Water Supply System Performance Indicators Based on the Customer Bill-Based Approach
Authors: Sambeto Bibi Takele , Hordofa Dinsa Beyene , Tesseme Aragaw Tamru 
Published: October 2023

Significant efforts have been undertaken over the last two decades by governmental organizations and local and international non-governmental sectors to improve water supply and sanitation structures; however, there are significant challenges to the town's growth and expansion. Chiro town's population is increasing, and the community is affected by water and excreta-borne diseases as a result of a lack of proper sanitation facilities and a water supply system. In this study, billed data from Chiro Town water supply service enterprise customers have been used to assess the performance of the water distribution network over ten years (2011-2020). The findings show that the Town's water coverage is 62.9%, the water demand is 8,121.6m3/day, and the computed annual water production is 4,222.3m3/day. Residents of the town have complained about a lack of access to improved drinking water supplies, low water consumption, and sanitation facilities, particularly in the community of those who live in the town's borders and practice open defecation. For all domestic use, 16.32% and 83.68% of respondents used unprotected and protected water sources, respectively. This study suggested that strong sectoral coordination, community involvement, and sufficient financial resources were required to identify the root causes and provide an efficient water supply system in the study area.
Analisis Ergonomika Pengoperasian Bagian Pencacah pada Mesin Pencacah Pakan Ternak Multiguna
Authors: Anggiana Ayu , Suharyatun Siti , Wisnu Febryan Kusuma , Warji Warji 
Published: October 2023

The multi-purpose animal feed chopping machine is one of the feed chopping tools that many farmers use to help speed up the chopping of raw materials that will be used as animal feed. The chopping machine can be operated optimally if the machine is ergonomic so that it is safe and comfortable to operate. This study aims to analyze the ergonomics of a multi-purpose animal feed chopper in terms of anthropometry, operating workload and the level of work fatigue specifically for the chopper. This research uses quantitative methods which are supported by literature studies regarding the design of creating machine dimensions. The parameters in this study are: (1) anthropometric data consisting of Standing Finger Tip Height (TJUB), Standing Vertical Reach (JVB), and Standing Horizontal Reach (JHB); (2) the recommended weight limit that can be lifted by the operator (RWL), and (3) cardiovascular load (CVL). The research results stated that the height of the chopper hopper (100 cm) was classified as ergonomic because it was still between TJUB (66.10 cm) and JVB (183.95 cm). The operator's position from the hopper should not exceed JHB (66.00 cm). The recommended load limit (RWL) is 5.38 kg. Operation of the machine chopper section does not cause work fatigue with an average CVL of 10.71% (≤ 30%). Keywords: Anthropometry, CVL, Pulse Rate, RWL, Work Fatigue.