bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary pituitary tuberculoma with a pituitary apoplexy-like presentation
Authors: Krishnan Gaayathri , Mohd Makhatar Nur Hidayah , Ching Tee Hwee , Khoo Serena 
Published: January 2024

Summary
Pituitary tuberculoma is extremely rare and may pose as a diagnostic challenge especially when encountered as an isolated lesion without other systemic manifestation of tuberculosis. A 21-year-old female was admitted for diabetic ketoacidosis. On the third day of admission following the resolution of diabetic ketoacidosis she developed a sudden onset of headache and blurring of vision suggestive of pituitary apoplexy. An urgent MRI brain revealed a large sellar mass with erosion into the sphenoid sinus and intracranial vasculitis. Transphenoidal surgery was done for tumour debulking which allowed histopathological examination of the sellar mass. Immunohistochemical examination of the sellar mass was positive for Gene Xpert MTB/Rif suggesting a tuberculoma. Anti-tuberculous therapy was commenced with full recovery of pituitary hormonal profile seen 7 months post-treatment. In regions with a high incidence of tuberculosis, a tuberculoma should be a considered in a diagnostic evaluation of a sellar lesion.

Learning points

In an endemic area of tuberculosis, tuberculoma should be considered as a differential diagnosis when evaluating sellar lesions.

Pituitary tuberculoma can present with pituitary apoplexy-like symptoms.

Prompt diagnosis and treatment may lead to recovery of pituitary function.
Diabetes mellitus in Kabuki syndrome 1 on a background of post-transplant diabetes mellitus
Authors: Chew Sue Mei S , Pritchard N , Grayton H , Simonicova I , Park S M , Adler A I 
Published: January 2024

Summary
Kabuki syndrome is a genetic disorder characterised by distinctive facial features, developmental delays, and multisystem congenital anomalies. Endocrine complications such as premature thelarche and short stature are common, whereas disorders of glycaemic control are less frequent. We describe a 23-year-old white female referred to the diabetes clinic for hyperglycaemia during haemodialysis. She was subsequently diagnosed with Kabuki syndrome based on characteristic clinical features, confirmed by detecting a heterozygous pathogenic variant in KMT2D. She was known to have had multiple congenital anomalies at birth, including complex congenital heart disease and a single dysplastic ectopic kidney, and received a cadaveric transplanted kidney at the age of 13. She had hyperglycaemia consistent with post-transplant diabetes mellitus (DM) and was started on insulin. Examination at the time revealed truncal obesity. She developed acute graft rejection and graft failure 14 months post-transplant and she was started on haemodialysis. Her blood glucose levels normalised post-graft explant, but she was hyperglycaemic again during haemodialysis at the age of 23. Given her clinical phenotype, negative diabetes antibodies and normal pancreas on ultrasound, she was assumed to have type 2 DM and achieved good glycaemic control with gliclazide.

Learning points

Involve clinical genetics early in the investigative pathway of sick neonates born with multiple congenital anomalies to establish a diagnosis to direct medical care.

Consider the possibility of Kabuki syndrome (KS) in the differential diagnoses in any neonate with normal karyotyping or microarray analysis and with multiple congenital anomalies (especially cardiac, renal, or skeletal), dysmorphic facial features, transient neonatal hypoglycaemia and failure to thrive.

Consider the possibility of diabetes as an endocrine complication in KS patients who are obese or who have autoimmune disorders.
(Ne)susvetimėjimas Lietuvos mokyklose: keturių abiturientų atvejų analizė
Authors: Labokas Juozapas 
Published: January 2024

This article focuses on the alienation manifested in the field of the teacher-student relationship. The study uses Morinaj, Hadjar and Hascher’s (2020) quantitative-diagnostic instrument for determining the level of alienation, with the help of which participants experiencing 2 high and 2 low alienation in relation to teachers were selected from the studied population of twelfth graders (n=227). The latter were invited to a qualitative semi-structured interview. The aim of this study was to better understand the problem of alienation in the student–teacher relation, discuss and reflect on the possibilities of the diagnostic instrument and reveal the experiences of (non)alienation of four research participants. It was found that the participants interpreted the statements of the instrument differently, giving different answers, which could potentially distort the results of the diagnostic study. The revealed diversity of pedagogical experiences showed that alienation is an individual and multifaceted phenomenon, thus it is meaningful to supplement further alienation research with a qualitative methodological perspective.
Outcome of BMI2+: Motivational Interviewing to Reduce BMI Through Primary Care AAP PROS Practices
Authors: Resnicow Ken , Delacroix Emerson , Sonneville Kendrin R. , Considine Shannon , Grundmeier Robert W. , Shu Di , Faerber Jennifer A. , Fiks Alexander G. , Steffes Jennifer , Harris Donna , Woo Heide , Proctor Tim , Wright Margaret E. , Shone Laura P. , Barlow Sarah E. , Wasserman Richard C. , Siegel Robert , Stockwell Melissa S. 
Published: January 2024

BACKGROUND
Pediatric obesity rates in the United States remain at an all-time high. Pediatric primary care clinicians and registered dietitians can help treat childhood obesity, and motivational interviewing (MI) has shown promising effects in prior trials.

METHODS
We randomized 18 pediatric primary care practices to receive the Brief Motivational Interviewing to Reduce BMI or BMI2+ intervention or continue with usual care (UC). Practices were recruited through the American Academy of Pediatrics Pediatric Research in Office Settings network. The intervention comprised 4 components1: in-person and telehealth MI counseling by pediatric clinicians; 4 recommended sessions,2 6 telephone MI counseling sessions from a registered dietitian,3 text message reminders and tailored motivational messages, and4 parent educational materials. The main outcome was the change in the percentage of the 95th percentile of BMI. The study was conducted 2017 through 2021.

RESULTS
There was a significant treatment x time interaction (b = 0.017, 95% confidence interval: [0.0066–0.027]) for the main outcome, favoring the UC group, with youth in the intervention arm showing a greater relative increase in their percent of the 95th percentile.

CONCLUSIONS
There was no overall benefit of the intervention and, contrary to expectations, youth in the intervention arm gained more weight, based on percent of the distance from the 95th percentile than matched youth from UC practices. The absolute excess weight gain among intervention relative to UC youth was small, approximately 0.5 BMI units and 1 kg over 2 years. We offer several potential explanations for these unexpected findings.
Outbreak caused by pandrug-resistant blaOXA-69/blaOXA-23/blaGES harboring Acinetobacter baumannii ST2 in an intensive care unit
Authors: Raddaoui Anis , Mabrouk Aymen , Chebbi Yosra , Frigui Siwar , Al-Gallas Nazek , Abbassi Mohamed Salah , Achour Wafa 
Published: January 2024

AbstractAcinetobacter baumannii has emerged as a main nosocomial pathogen exhibiting high rates of resistance to clinically relevant antibiotics. Six pandrug-resistant A. baumannii (PDR-A. baumannii) were recovered from three patients in a Tunisian Intensive Care Unit (ICU) between 10th and 16th of May 2018 resulting in one fatal case and raising the possibility of an outbreak. On 18th of May environmental screening of ICU surfaces was carried out. On 22nd of May a fourth patient was infected with PDR-A. baumannii and died. A second investigation was carried out for environmental screening and PDR-A. baumannii was isolated from the respirator. Antimicrobial susceptibility testing was performed according to EUCAST (2019) guidelines. MIC of colistin was determined by broth microdilution method. PCR was used to detect 14 beta-lactamases/carbapenemases and mcr (mcr-1 to mcr-5) genes. The genetic relatedness of PDR-A. baumannii isolates was determined by PFGE and MLST. Seven PDR-A. baumannii isolates were recovered from four patients, one MDR strain from wash basin, a PDR strain from hand sanitizer bottle and another PDR strain from respirator. All PDR-A. baumannii (n = 9) harbored blaOXA-69 gene and none carried mcr. Moreover, seven carried blaGES and blaOXA-23 genes. PFGE identified four pulsotypes (A, B, C, and D) with the pulsotype A gathering seven PDR-A. baumannii isolates: six from three patients and one from hygiene sample. MLST revealed that all PDR-A. baumannii isolates of pulsotype A belonged to the pandemic clone ST2. Systematic screening of MDR and PDR-A. baumannii is highly recommended to limit dissemination of such strains in ICUs.
VHL-dependence of EHHADH Expression in a Human Renal Cell Carcinoma Cell Line
Authors: Pilz Julia Felicitas , Klein Marinella , Neumann-Haefelin Elke , Ganner Athina 
Published: January 2024

The von Hippel-Lindau tumor suppressor gene (VHL) is mutated in up to 90% of clear cell renal cell carcinoma (ccRCC) cases, thus playing a key role in ccRCC pathogenesis. ccRCC can be classified as a metabolic disease in which alterations in fatty acid metabolism facilitate cancer cell proliferation. Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase (EHHADH) is an enzyme involved in peroxisomal fatty acid degradation. It is primarily expressed in renal proximal tubule cells, presumably the origin of ccRCC. Although EHHADH is still a relatively unexplored gene, it is known to be differentially expressed in several tumors. In this study, analysis of several databases revealed that EHHADH expression is downregulated in ccRCC samples compared to healthy kidney samples. Moreover, cell culture experiments were performed to investigate the relationship between EHHADH and VHL at the gene and protein level. qPCR and Western blot analyses using the human ccRCC cell line RCC4 revealed that EHHADH is expressed in a VHL-dependent manner. RCC4 cells reconstituted with VHL show significantly higher EHHADH mRNA and protein levels than VHL-deficient RCC4 control cells. These results indicate that the downregulation of EHHADH in ccRCC reported may be due to the loss of VHL function. This study is the first to molecularly characterize EHHADH, a key enzyme in peroxisomal ß-oxidation, in relation to VHL, suggesting a potential pathogenic interaction that is worthy of further investigation.
Simultaneously transmitting and reflecting (STAR) RISs for 6G: fundamentals, recent advances, and future directions
Authors: Liu Yuanwei , Xu Jiaqi , Wang Zhaolin , Mu Xidong , Zhang Jianhua , Zhang Ping 
Published: January 2024

AbstractSimultaneously transmitting and reflecting reconfigurable intelligent surfaces (STAR-RISs) have been attracting significant attention in both academia and industry for their advantages of achieving 360° coverage and enhanced degrees-of-freedom. This article first identifies the fundamentals of STAR-RIS, by discussing the hardware models, channel models, and signal models. Then, three representative categorizing approaches for STAR-RISs are introduced from the phase-shift, directional, and energy consumption perspectives. Furthermore, the beamforming design of STAR-RISs is investigated for both independent and coupled phase-shift cases. As a recent advance, a general optimization framework, which has high compatibility and provable optimality regardless of the application scenarios, is proposed. As a further advance, several promising applications are discussed to demonstrate the potential benefits of applying STAR-RISs in sixth-generation wireless communication. Lastly, a few future directions and research opportunities are highlighted.
BIOGAS ENERGY COMPLEX «BIOGAS NORD» IMPROVEMENT BY RATIONALIZING THE WASTEWATER TREATMENT SCHEME OF THE LIVESTOCK COMPLEX
Authors: Uretski E. A. , Nikolenko I. V. , Moroz V. V. 
Published: January 2024

Livestock, pig and poultry farms generate large amounts of organic waste, which pose a serious hazard to the environment. A radical solution to this problem is the use of non-traditional technologies for treating organic waste on livestock farms, aimed at converting this waste into thermal or electrical energy. One of the well-known and widely used non-traditional technologies abroad is the use of primary or secondary waste from livestock farms as sources of renewable energy. In the Republic of Belarus, a large number of livestock breeding complexes have been built and operated, based on the use of progressive flow technologies for meat production. The hydroflush removal of manure from livestock buildings used in this case led to the formation of significant volumes of highly concentrated wastewater, as well as liquid manure, solid manure and slurry. These wastes pose a serious hazard to the natural environment. The main form of their disposal is watering, without any preliminary treating and disinfection. An analysis of the treatment facilities of livestock complexes operating in the Republic of Belarus showed that in the republic there are practically
no not only effective wastewater treatment facilities for such complexes, but also technologies for sludge processing. Biogas technologies are one of the main modern methods of recycling organic waste of animal origin using the production of biogas (gaseous fuel) and environmentally friendly organic fertilizers. Such technologies make it possible to comprehensively solve the problem of energy, agrochemistry and ecology.
The article discusses the radical reconstruction of the design settling tanks, which increased the productivity of the existing biogas plant from 200 to 1000 kW, and the addition of the technological scheme with a block for binding an inhibitor of biological processes of excess ammonium in MgNH3PO4∙6H2O (magnesium ammonium orthophosphate – struvite) not only made it possible to significantly improve the process of biological wastewater treatment, and also obtain a complex fertilizer suitable for all crops. A radical reconstruction of the technological scheme increased the efficiency of wastewater treatment to the maximum permissible concentration, allowing its discharge into water bodies.
La escritura a través de los géneros en el marco educativo basado en las competencias: el caso del País Vasco / Gender-based writing in the competency-based educational framework: the case of the Basque Country
Authors: Boillos Pereira Mari Mar 
Published: January 2024

Resumen:
Conscientes de las carencias escritoras de los estudiantes en diferentes etapas educativas, la documentación en materia de educación del Gobierno Vasco (decretos y líneas metodológicas) ha puesto de relieve esta problemática y ha mostrado su preocupación por mejorar la formación escritora de los estudiantes. La competencia comunicativa y, por extensión, las diferentes actividades comunicativas de la lengua, entre ellas, la escritura, han pasado a ser esenciales no sólo en las materias de lenguas, sino de manera transversal a todas las materias. En esta línea, este trabajo busca conocer las posibilidades que el enfoque basado en los géneros ofrece para dar respuesta a esta demanda formativa. Este enfoque defiende el uso de los géneros como eje para la construcción de tareas en las que se van desarrollando las habilidades para interactuar en una comunidad discursiva. Los resultados muestran las posibilidades de esta aplicación y las futuras líneas de trabajo posibles.
Palabras clave: desarrollo de las habilidades; educación básica; escritura; lenguas; competencias.

Abstract: Aware of students’ lack of writing skills in different stages of education, the Basque Government's documentation on Education (decrees and methodological guidelines) has highlighted this problem and has shown its concern to improve student writing. Communicative competence and, by extension, the different communicative activities of the language, including writing, have become essential not only in language subjects, but also transversely to all subjects. In this line, this work seeks to know the possibilities that the Genre-based Approach offers to respond to this teaching demand. This approach defends the use of genres as the axis for the construction of tasks in which skills are developed to interact in a discursive community. The results show the possibilities of this approach and the possible future lines of work.
Keywords: development of skills; basic education, writing; languages; skills.
American Literature for Millennial and Centennial Undergraduates: Reflections upon an Eclectic Teaching Model / La literatura norteamericana para universitarios millennials y centennials: : Reflexiones en torno a un modelo ecléctico de enseñanza
Authors: Cañero Serrano Julio 
Published: January 2024

La cuestión del canon en aula de literatura norteamericana de la universidad española ha estado, con toda lógica, influida por las denominadas ‘Guerras Culturales’ que desde los años noventa del siglo pasado se han librado en Estados Unidos entre los partidarios de mantener una tradición próxima al pensamiento dominante y los que han intercedido por la apertura de esa tradición a voces obliteradas. Partiendo de la definición de lo literario frente a lo no literario, este trabajo se adentra en las distintas corrientes que han determinado el canon literario de ese país y las que lo han rechazado por dejar sin voz a determinados grupos (mujeres, inmigrantes, clase trabajadora, o minorías étnicas, raciales o de orientación sexual). Ante los desafíos que representan una nueva generación de alumnos universitarios españoles, los denominados millennials y centennials, mucho más receptivos a las creaciones del ‘Otro’ -independientemente de si esas creaciones son distintivas, por su origen o por su carácter formal, de lo entendido como literario,- reflexionamos sobre la necesidad de abogar por una aproximación docente de corte ecléctica a la creación artísticas estadounidense, conjugando el requisito de conocer las obras canónicas con estudiar también en nuestras aulas aquellas que la tradición ha denostado.

Abstract
The question of the canon in American Literature classroom of Spanish universities is influenced by the ‘Cultural Wars’ that, since the 1990s, have been fought in the United States between the supporters of maintaining a tradition close to the dominant thought, and those that have defended the opening of the canon to obliterated voices. Starting from the definition of literary versus non-literary, this work delves into the tendencies that have determined the literary canon of the US, and those which have rejected it for its concealment of the voices of important segments of the American population (women, immigrants, and class, ethnic, racial or sexual-oriented groups). Acknowledging that today’s teachers face the challenges posed by a new generation of university students, the so-called Millennials and Centennials, who are much more receptive to the creations of the ‘Other’ -regardless of whether these creations are distinctive, by their origin or by their formal character, of what is understood as literary,- we ponder upon the need to advocate an eclectic teaching approach to American artistic creations, combining the requirement to know the canonical works with the study of those pieces of work that the tradition has reviled.
Keywords: American Literature; Canon; Teaching; Cultural Diversity.
Flipping the classroom for higher education learners to improve productive and receptive skills / Invertir la clase con estudiantes universitarios para mejorar las destrezas productivas y receptivas
Authors: Calle Martínez Cristina 
Published: January 2024

Este estudio examina la capacidad de los estudiantes de Turismo para abordar las quejas de clientes utilizando el enfoque de aula invertida combinado con la implementación del programa en línea VoiceThread. El estudio se llevó a cabo con un grupo de 49 estudiantes ILE en el Grado de Turismo en la Universidad Complutense de Madrid. El estudio se llevó a cabo en 3 fases: (1) a los estudiantes se les proporcionó material en Campus Virtual con expresiones útiles relacionadas con las quejas de clientes, que los estudiantes debían consultar antes de la siguiente clase. (2) En el laboratorio de idiomas, los estudiantes debían escuchar una queja de un cliente y darle una respuesta satisfactoria mediante grabación de su propia voz. (3) Para recabar información sobre la opinión que tenían de esta actividad experimental, a los estudiantes se les pidió que cumplimentaran un cuestionario Google. En general, los resultados del estudio han demostrado el impacto positivo de este método en el proceso de enseñanza/aprendizaje en las clases de ILE para los estudiantes de turismo, contribuyendo a su motivación y al desarrollo de sus habilidades profesionales.

Abstract
This study examines the ability of Tourism students to deal with customer complaints by using the flipped classroom approach combined with the implementation of the online VoiceThread programme. The study was carried out with a group of 49 EFL students in the Degree of Tourism at the University Complutense of Madrid. The study was carried out in 3 phases: (1) students were provided with audio material containing some useful expressions related to customers’ complaints. This material was made available on the Virtual Platform (Campus Virtual) so students could consult it as they needed before the following class. (2) In the computing room, students were asked to listen to a customer complaint and to give a solution by recording their own voices. (3) In order to gather students’ opinions about this experimental activity, students were asked to fill in a Google form questionnaire. Overall, the results of the study have shown the positive impact of this method on the teaching/learning process in the EFL classes for Tourism students, contributing to their motivation and development of their professional skills
Keywords: flipped classroom; EFL; tourism; customer complaints; professional skills