bluuebunny/crossref_metadata_2025_split huggingface dataset:
Octopi Tentacles‐Inspired Architecture Enables Self‐Healing Conductive Rapid‐Photo‐Responsive Materials for Soft Multifunctional Actuators
Authors: Shi Xiangrong , Zhang Kuiyuan , Chen Juxiang , Qian Hanqi , Huang Yudong , Jiang Bo 
Published: October 2023

AbstractTo mimic biological systems' healing mechanism and sensory motion, the combination of self‐healing, perception, and actuation in a singular soft artificial material is required, which would be enormously valuable for soft robotics that commit to obtaining multifunction and local sensing capacities approaching living organisms. However, most existing soft somatosensory actuators lack self‐healing capability to injuries, and suffer from insufficient actuating performance and sensitivity, and complicated manufacturing operations. Herein, a bioinspired conductive photo‐responsive architecture is reported. Rapidly photo‐responsive anthracene, self‐healing matrix with dynamic interactions, and high‐conductivity slideable silver nanowires chemically integrated with matrix are respectively utilized to mimic the neuromuscular system and effectors, biological tissue systems, and nerve cords and receptors of octopus tentacles. Such a soft somatosensory actuator exhibits rapid actuation (light‐driven bending velocity, 10o s−1), distinctive intrinsic strain sensitivity (gauge factor, 90.88), and decent self‐healing efficiency (92.2%). As a proof of concept, octopi tentacles‐inspired smart grippers are fabricated for various photo‐responsive motions including bending, weightlifting and object grasping that can contemporaneously detect actions by real‐time resistance changes and provide information feedback. This work is anticipated to bring fresh horizons in the design of multifunctional sensory actuating materials and establish a pathway for the advancement of self‐diagnostic soft robots.
Degradable Microneedle Patch Loaded with Doxycycline Hydrochloride and Vascular Endothelial Growth Factors for Promoting Diabetic Wound Healing
Authors: Tan Yufang , Wang Yichen , Zeng Ning , Zhang Qi , Wu Min , Wu Yiping 
Published: October 2023

AbstractDifficult‐to‐heal skin wounds are serious complications of diabetes. Microneedles (MNs) are a new type of physically penetrating wound dressing that can synergistically carry drugs. In this study, good biocompatible gelatin methacrylate (Gelma) and polyvinyl alcohol (PVA), loading with doxycycline hydrochloride (DH) and vascular endothelial growth factors (VEGF) are used to prepare the DH/VEGF@Gelma‐MNs. Gelma‐MNs possess well‐aligned conical structures, good mechanical, and swelling properties, and could penetrate the skin. DH/VEGF@Gelma‐MNs show biocompatibility and antibacterial ability to inhibit the growth of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Besides, DH/VEGF@Gelma‐MNs significantly promote the migration and tube formation of human umbilical vein endothelial cells (HUVECs). DH/VEGF@Gelma‐PNs treatment accelerates diabetic wound closure in vivo compared to DH/VEGF@Gelma‐plain patch (DH/VEGF@Gelma‐PPs) flat patch and DH/VEGF solution injection. Histological evaluation shows that DH/VEGF@Gelma‐MNs coverage presents intact wound re‐epithelialization, follicle and sebaceous gland formation, more collagen deposition and remodeling, and angiogenesis. In conclusion, DH/VEGF@Gelma‐MNs exert antimicrobial and angiogenic effects by releasing DH and VEGF to promote diabetic wound healing, posing an intriguing strategy based on a synergistic MN therapeutic platform.
CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR‐212‐5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway
Authors: Yuan Menglang , Zhang Xinsheng , Yue Fangxia , Zhang Feifan , Jiang Sufen , Zhou Xu , Lv Jinjuan , Zhang Zhenyu , Sun Yuzhu , Chen Zihao , Wu Han , Liu Xiaoqian , Yu Xiaoqi , Wei Bowen , Jiang Kexin , Lin Fang , Zuo Yunfei , Ren Shuangyi 
Published: October 2023

AbstractLiver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway‐associated circular RNA, circNOLC1, plays a crucial role in colorectal cancer liver metastasis. It is found that circNOLC1 silencing reduces the oxidative pentose phosphate pathway‐related intermediate metabolites and elevates NADP+/NADPH ratio and intracellular ROS levels, thereby attenuating colorectal cancer cell proliferation, migration, and liver metastasis. circNOLC1 interacting with AZGP1 to activate mTOR/SREBP1 signaling, or sponging miR‐212‐5p to upregulate c‐Met expression, both of which can further induce G6PD to activate oxidative pentose phosphate pathway in colorectal cancer liver metastasis. Moreover, circNOLC1 is regulated by the transcription factor YY1 and specifically stabilized HuR induces its parental gene mRNA expression. The associations between circNOLC1 and these signaling molecules are validated in primary CRC and corresponding liver metastasis tissues. These findings reveal that circNOLC1 interacting with AZGP1 and circNOLC1/miR‐212‐5p/c‐Met axis plays a key role in oxidative pentose phosphate pathway‐mediated colorectal cancer liver metastasis, which may provide a novel target for precision medicine of colorectal cancer.
Symmetrical Catalytic Colloids Display Janus‐Like Active Brownian Particle Motion
Authors: Archer Richard J. , Ebbens Stephen J. 
Published: October 2023

AbstractCatalytic Janus colloids, with one hemi‐sphere covered by a hydrogen peroxide reduction catalyst such as platinum, represent one of the most experimentally explored examples of self‐motile active colloid systems. This paper comparatively investigates the motile behavior of symmetrical catalytic colloids produced by a solution‐based metal salt reduction process. Despite the significant differences in the distribution of catalytic activity, this study finds that the motion produced by symmetrical colloids is equivalent to that previously reported for Janus colloids. It also shows that introducing a Janus structure to the symmetrical colloids via masking does not significantly modify their motion. These findings could indicate that very subtle variations in surface reactivity can be sufficient to produce Janus‐like active Brownian particle‐type motion, or that a symmetry‐breaking phenomena is present. The study will consequently motivate fresh theoretical attention and also demonstrate a straightforward route to access large quantities of motile active colloids, which are expected to show subtly different phenomenology compared to those with Janus structures.
Trimethylsilyl Compounds for the Interfacial Stabilization of Thiophosphate‐Based Solid Electrolytes in All‐Solid‐State Batteries
Authors: Kim Kanghyeon , Kim Taehun , Song Gawon , Lee Seonghyun , Jung Min Soo , Ha Seongmin , Ha A. Reum , Lee Kyu Tae 
Published: October 2023

AbstractArgyrodite‐type Li6PS5Cl (LPSCl) has attracted much attention as a solid electrolyte for all‐solid‐state batteries (ASSBs) because of its high ionic conductivity and good mechanical flexibility. LPSCl, however, has challenges of translating research into practical applications, such as irreversible electrochemical degradation at the interface between LPSCl and cathode materials. Even for Li‐ion batteries (LIBs), liquid electrolytes have the same issue as electrolyte decomposition due to interfacial instability. Nonetheless, current LIBs are successfully commercialized because functional electrolyte additives give rise to the formation of stable cathode‐electrolyte interphase (CEI) and solid‐electrolyte interphase (SEI) layers, leading to supplementing the interfacial stability between electrolyte and electrode. Herein, inspired by the role of electrolyte additives for LIBs, trimethylsilyl compounds are introduced as solid electrolyte additives for improving the interfacial stability between sulfide‐based solid electrolytes and cathode materials. 2‐(Trimethylsilyl)ethanethiol (TMS‐SH), a solid electrolyte additive, is oxidatively decomposed during charge, forming a stable CEI layer. As a result, the CEI layer derived from TMS‐SH suppresses the interfacial degradation between LPSCl and LiCoO2, thereby leading to the excellent electrochemical performance of Li | LPSCl | LiCoO2, such as superior cycle life over 2000 cycles (85.0% of capacity retention after 2000 cycles).
A Bacterial mRNA‐Lysis‐Mediated Cargo Release Vaccine System for Regulated Cytosolic Surveillance and Optimized Antigen Delivery
Authors: Li Yu‐an , Sun Yanni , Zhang Yuqin , Li Quan , Wang Shifeng , Curtiss Roy , Shi Huoying 
Published: October 2023

AbstractEngineered vector‐based in vivo protein delivery platforms have made significant progress for both prophylactic and therapeutic applications. However, the lack of effective release strategies results in foreign cargo being trapped within the vector, restricting the provision of significant performance benefits and enhanced therapeutic results compared to traditional vaccines. Herein, the development of a Salmonella mRNA interferase regulation vector (SIRV) system is reported to overcome this challenge. The genetic circuits are engineered that (1) induce self‐lysis to release foreign antigens into target cells and (2) activate the cytosolic surveillance cGAS‐STING axis by releasing DNA into the cytoplasm. Delayed synthesis of the MazF interferase regulates differential mRNA cleavage, resulting in a 36‐fold increase in the delivery of foreign antigens and modest activation of the inflammasome, which collectively contribute to the marked maturation of antigen‐presenting cells (APCs). Bacteria delivering the protective antigen SaoA exhibits excellent immunogenicity and safety in mouse and pig models, significantly improving the survival rate of animals challenged with multiple serotypes of Streptococcus suis. Thus, the SIRV system enables the effective integration of various modular components and antigen cargos, allowing for the generation of an extensive range of intracellular protein delivery systems using multiple bacterial species in a highly efficient manner.
Highly‐Specific Single‐Stranded Oligonucleotides and Functional Nanoprobes for Clinical Determination of Chlamydia Trachomatis and Neisseria Gonorrhoeae Infections
Authors: Dighe Ketan , Moitra Parikshit , Gunaseelan Nivetha , Alafeef Maha , Jensen Tor , Rafferty Carla , Pan Dipanjan 
Published: October 2023

AbstractEarly detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) is the key to controlling the spread of these bacterial infections. An important step in developing biosensors involves identifying reliable sensing probes against specific genetic targets for CT and NG. Here, the authors have designed single‐stranded oligonucleotides (ssDNAs) targeting mutually conserved genetic regions of cryptic plasmid and chromosomal DNA of both CT and NG. The 5′‐ and 3′‐ ends of these ssDNAs are differentially functionalized with thiol groups and coupled with gold nanoparticles (AuNP) to develop absorbance‐based assay. The AuNPs agglomerate selectively in the presence of its target DNA sequence and demonstrate a change in their surface plasmon resonance. The optimized assay is then used to detect both CT and NG DNA extracted from 60 anonymized clinical samples with a clinical sensitivity of ∼100%. The limit of detection of the assays are found to be 7 and 5 copies/µL for CT and NG respectively. Furthermore, it can successfully detect the DNA levels of these two bacteria without the need for DNA extraction and via a lateral flow‐based platform. These assays thus hold the potential to be employed in clinics for rapid and efficient monitoring of sexually transmitted infections.
Triply Enhanced Immunotherapy via Dual Glycan Reforming Integrated with Perforation
Authors: Yang Yuanjiao , Wang Yuru , Chao Zhicong , Yang Yuhui , Fang Yanyun , Liu Ying , Ding Lin , Chen Yunlong , Ju Huangxian 
Published: October 2023

AbstractThe enhancement of immunotherapy is an emerging direction to develop highly effective and practical cancer therapeutic methods. Here a triply enhanced immunotherapy drug (TEID) is designed for ingeniously integrating in situ dual glycan reforming with perforation on cell membrane. The TEID is composed of galactose and neuraminidase conjugated streptolysin O (SLO‐Gal and SLO‐NEU), which are encapsulated in a hyaluronic acid (HA) shell for targeted recognition to tumor tissue via cell surface CD44. After targeted delivery and HAase‐mediated degradation in the tumor region, the TEID releases SLO‐Gal and SLO‐NEU, which can easily anchor Gal and NEU on the tumor cell membrane via the perforation of SLO to perform dual glycan reforming for the introduction of Gal and the cleavage of sialic acid. The former can activate immune cells to secret cytokines for immune‐killing, and the latter can weaken the immune inhibition to improve the immunotherapeutic efficacy. Meanwhile, the perforation of SLO can promote the delivery of cytokines into the tumor cells to further enhance the efficacy. The designed triply enhanced immunotherapy strategy opens a significant and promising route to promote clinical immunotherapy of cancer.
Shape‐Anisotropic Assembly of Protein Nanocages with Identical Building Blocks by Designed Intermolecular π–π Interactions
Authors: Chen Xuemin , Zhang Tuo , Liu Hanxiong , Zang Jiachen , Lv Chenyan , Du Ming , Zhao Guanghua 
Published: October 2023

AbstractProtein lattices that shift the structure and shape anisotropy in response to environmental cues are closely coupled to potential functionality. However, to design and construct shape‐anisotropic protein arrays from the same building blocks in response to different external stimuli remains challenging. Here, by a combination of the multiple, symmetric interaction sites on the outer surface of protein nanocages and the tunable features of phenylalanine‐phenylalanine interactions, a protein engineering approach is reported to construct a variety of superstructures with shape anisotropy, including 3D cubic, 2D hexagonal layered, and 1D rod‐like crystalline protein nanocage arrays by using one single protein building block. Notably, the assembly of these crystalline protein arrays is reversible, which can be tuned by external stimuli (pH and ionic strength). The anisotropic morphologies of the fabricated macroscopic crystals can be correlated with the Å‐to‐nm scale protein arrangement details by crystallographic elucidation. These results enhance the understanding of the freedom offered by an object's symmetry and inter‐object π−π stacking interactions for protein building blocks to assemble into direction‐ and shape‐anisotropic biomaterials.
Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice
Authors: Xu Yanchao , Yang Dengbao , Wang Lu , Król Elżbieta , Mazidi Mohsen , Li Li , Huang Yi , Niu Chaoqun , Liu Xue , Lam Sin Man , Shui Guanghou , Douglas Alex , Speakman John R. 
Published: October 2023

AbstractEarly life nutrition can reprogram development and exert long‐term consequences on body weight regulation. In mice, maternal high‐fat diet (HFD) during lactation predisposed male but not female offspring to diet‐induced obesity when adult. Molecular and cellular changes in the hypothalamus at important time points are examined in the early postnatal life in relation to maternal diet and demonstrated sex‐differential hypothalamic reprogramming. Maternal HFD in lactation decreased the neurotropic development of neurons formed at the embryo stage (e12.5) and impaired early postnatal neurogenesis in the hypothalamic regions of both males and females. Males show a larger increased ratio of Neuropeptide Y (NPY) to Pro‐opiomelanocortin (POMC) neurons in early postnatal neurogenesis, in response to maternal HFD, setting an obese tone for male offspring. These data provide insights into the mechanisms by which hypothalamic reprograming by early life overnutrition contributes to the sex‐dependent susceptibility to obesity in adult life in mice.
Additive Manufacturing of Transparent Multi‐Component Nanoporous Glasses
Authors: Li Beining , Li Zhenjiang , Cooperstein Ido , Shan Wenze , Wang Shuaipeng , Jiang Benxue , Zhang Long , Magdassi Shlomo , He Jin 
Published: October 2023

AbstractFabrication of glass with complex geocd the low resolution of particle‐based or fused glass technologies. Herein, a high‐resolution 3D printing of transparent nanoporous glass is presented, by the combination of transparent photo‐curable sol–gel printing compositions and digital light processing (DLP) technology. Multi‐component glass, including binary (Al2O3‐SiO2), ternary (ZnO‐Al2O3‐SiO2, TiO2‐Al2O3‐SiO2), and quaternary oxide (CaO‐P2O5‐Al2O3‐SiO2) nanoporous glass objects with complex shapes, high spatial resolutions, and multi‐oxide chemical compositions are fabricated, by DLP printing and subsequent sintering process. The uniform nanopores of Al2O3‐SiO2‐based nanoporous glasses with the diameter (≈6.04 nm), which is much smaller than the visible light wavelength, result in high transmittance (>95%) at the visible range. The high surface area of printed glass objectives allows post‐functionalization via the adsorption of functional guest molecules. The photoluminescence and hydrophobic modification of 3D printed glass objectives are successfully demonstrated. This work extends the scope of 3D printing to transparent nanoporous glasses with complex geometry and facile functionalization, making them available for a wide range of applications.
Adaptive Multi‐Site Gradient Adsorption of Siloxane‐Based Protective Layers Enable High Performance Lithium‐Metal Batteries
Authors: Fang Shan , Wu Fanglin , Zhao Shangquan , Zarrabeitia Maider , Kim Guk‐Tae , Kim Jae‐Kwang , Zhou Naigen , Passerini Stefano 
Published: October 2023

AbstractLow Coulombic efficiency and significant capacity decay resulting from an unstable solid electrolyte interphase (SEI) and dendritic growth pose challenges to the practical application of lithium‐metal batteries. In this study, a highly efficient protection layer induced by octaphenylsilsesquioxane (OPS) with LiFSI salt is investigated. The OPS exhibits a strong adsorption energy with lithium, its multi‐site gradient adsorption ability enables the simultaneous capture of 8 Li+ and the uniform regulation of Li ion flux. Moreover, the mechanical strength and electronic insulation of the OPS layer induces Li deposition under the protection layer and effectively inhibits lithium dendrite growth. Such a protection layer contributes to the stable and dendrite‐free performance of a lithium‐metal battery employing LiNi0.8Co0.1Mn0.1O2 (NCM811) as a cathode and an ultrathin OPS‐protected lithium foil (20 µm) as the anode. A remarkable capacity retention of 91.4% is achieved after 300 cycles at 1C. The OPS‐protected Li anodes and NCM811 are also tested in combination with a Li1.5Al0.5Ge1.5(PO4)3 solid electrolyte, showing extended cyclability up to 300 cycles with an average Coulombic efficiency of 99.58% and capacity retention of 85.7%.
Present role of intraoperative enteroscopy in small bowel bleeding: A tertiary center experience
Authors: Huang Shu‐Wei , Lin Zong‐Wei , Chen Tsung‐Hsing , Chiu Cheng‐Tang , Huang Hsin‐Chih , Su Ming‐Yao , Chen Yu‐Jhou , Cheng Hao‐Tsai 
Published: October 2023

AbstractThe aim of this study was to assess the diagnostic yield and outcomes of intraoperative enteroscopy (IOE) in patients with overt small bowel bleeding in the era of balloon‐assisted enteroscopy and capsule endoscopy. We retrospectively reviewed the medical records of patients with small bowel bleeding who underwent IOE from January 2005 to April 2016 in a tertiary medical center. A total of 18 patients with overt small bowel bleeding who underwent a total 18 IOE procedures were included. The mean amount of blood transfusion was 35.7 units (SD, 21.4 units), and 11 patients had hypovolemic shock. The diagnostic yield of the IOE procedures was 94.4% (17/18). The most common pathologic diagnosis was ulcer. The rebleeding rate was 44.4% (8/18), and the overall survival rate was 61.1% (11/18). IOE remains a valuable tool for diagnosing overt small bowel bleeding. The usage of IOE might potentially be limited due to critical clinical conditions in the era of deep enteroscopy. A specific caution should be taken in performing IOE due to the high morbidity of the procedure.
Kinetic Delay in Cooperative Supramolecular Polymerization by Redefining the Trade‐Off Relationship between H‐Bonds and Van der Waals/π–π Stacking Interactions
Authors: Gallonde William T. , Poidevin Corentin , Houard Felix , Caytan Elsa , Dorcet Vincent , Fihey Arnaud , Bernot Kevin , Rigaut Stéphane , Galangau Olivier 
Published: October 2023

AbstractWe here present how rebalancing the interplay between H‐bonds and dispersive forces (Van der Waals/π–π stacking) may induce or not the generation of kinetic metastable states. In particular, we show that extending the aromatic content and favouring the interchain VdW interactions causes a delay into the cooperative supramolecular polymerization of a new family of toluene bis‐amide derivatives by trapping the metastable inactive state.
Cyclic Peptides for Drug Development
Authors: Ji Xinjian , Nielsen Alexander L. , Heinis Christian 
Published: October 2023

AbstractCyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady stream of new drugs, with an average of around one cyclic peptide drug approved per year. Powerful technologies for screening random peptide libraries, and de novo generating ligands, have enabled the development of cyclic peptide drugs independent of naturally derived molecules and now offer virtually unlimited development opportunities. In this review, we feature therapeutically relevant cyclic peptides derived from nature and discuss the unique properties of cyclic peptides, the enormous technological advances in peptide ligand development in recent years, and current challenges and opportunities for developing cyclic peptides that address unmet medical needs.
Nucleic Acid‐based Enzyme Cascades—Current Trends and Future Perspectives
Authors: Kröll Sandra , Niemeyer Christof M. 
Published: October 2023

AbstractThe natural micro‐ and nanoscale organization of biomacromolecules is a remarkable principle within living cells, allowing for the control of cellular functions by compartmentalization, dimensional diffusion and substrate channeling. In order to explore these biological mechanisms and harness their potential for applications such as sensing and catalysis, molecular scaffolding has emerged as a promising approach. In the case of synthetic enzyme cascades, developments in DNA nanotechnology have produced particularly powerful scaffolds whose addressability can be programmed with nanometer precision. In this minireview, we summarize recent developments in the field of biomimetic multicatalytic cascade reactions organized on DNA nanostructures. We emphasize the impact of the underlying design principles like DNA origami, efficient strategies for enzyme immobilization, as well as the importance of experimental design parameters and theoretical modeling. We show how DNA nanostructures have enabled a better understanding of diffusion and compartmentalization effects at the nanometer length scale, and discuss the challenges and future potential for commercial applications.