bluuebunny/crossref_metadata_2025_split huggingface dataset:
ФОРМУВАННЯ ІНШОМОВНОЇ КОМУНІКАТИВНОЇ КОМПЕТЕНТНОСТІ З ІНОЗЕМНОЇ МОВИ ЗА ПРОФЕСІЙНИМ СПРЯМУВАННЯМ У КУРСАНТІВ ВІЙСЬКОВИХ ВИЩИХ НАВЧАЛЬНИХ ЗАКЛАДІВ
Authors: Совгар Оксана , Левко Мар'яна 
Published: January 2024

У часи воєнного протистояння України з російською федерацією зростає практична потреба володіння англійською мовою як мовою міжнародного спілкування для військовослужбовців офіцерського складу Збройних Сил України. Відповідно, перед закладами вищої освіти постає необхідність внесення змін до силабусів і програм дисципліни «Іноземна мова за професійним спрямуванням», щоб задовільнити потреби майбутніх фахівців відповідно до вимог сьогодення, що зі свого боку передбачає створення курсів підготовки, які базуються на оцінці цілей і потреб, а також функцій, для виконання яких необхідна англійська мова.
У статті описано етапи створення курсу «Військова спеціалізована англійська (механізовані та танкові війська)» на базі підручника авторів М. Левко, О. Совгар, В. Бойченко, І. Антонів, О. Щерби, І. Тичини, проаналізовано його методичні основи, описано структуру і на основі розгляду зворотнього зв’язку від викладачів та майбутніх офіцерів експериментальних груп Національної академії сухопутних військ імені гетьмана Петра Сагайдачного виокремлено комплекс ефективних завдань, які формують та розвивають комунікативну компетентність з іноземної мови за професійним спрямуванням.
Створення курсу складалося з п’яти етапів: аналізу потреб, планування, проектування, написання та апробації. Курс включає сім тем, які не залежать одна від одної і можуть вивчатись як окремі модулі і покликаний формувати у курсантів спроможність використовувати лексичні одиниці за професійними темами у самостійних усних і письмових висловлюваннях; висловлювати та обґрунтовувати власну думку в дискусіях; описувати схеми, малюнки, складати доповіді до слайдів; а також розвивати навички читання, сприймання мови на слух, усного та письмового перекладу текстів із військово-професійної тематики.
Analisis Faktor-Faktor Yang Berhubungan Dengan Kejadian Otitis Media Supuratif Kronis Pada Pasien Anak
Authors: Boediarsih Boediarsih , Jamaluddin M , Megawati Rotin 
Published: January 2024

Otitis media supuratif kronis (OMSK) merupakan salah satu penyakit paling umum dari telinga tengah terutama di masa kecil. OMSK menyebabkan gangguan pada pendengaran dan mempengaruhi tumbuh kembang anak, bahkan komplikasi lebih lanjut dapat menyebabkan kematian. Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan kejadian OMSK pada pasien anak di klinik THT RSUD Batang. Metode Penelitian: desain penelitian cohort dengan pendekatan retrospektif, Sampel penelitian adalah pasien anak usia 1-18 tahun di klinik THT RSUD Batang tahun 2022. Terdapat 19 pasien OMSK dan 19 pasien non OMSK, pengamtan dilakukan dengan checklist dari data rekam medis. Analisa data dengan uji non parametrik Chi square dengan alternatif Fisher’s exact test. Hasil penelitian OMSK tidak memiliki hubungan yang signifikan dengan faktor berenang di kolam umum (p value 0,340>0,05) dan faktor paparan pasif merokok (p value 0,194>0,05). Hubungan yang signifikan pada faktor ISPA berulang (p value 0,045<0,05) dan OMA berulang (p value 0,009<0,05). Simpulan Anak-anak usia 6-9 tahun sangat beresiko mengalami OMSK, deteksi dini dan pengobatan yang adekuat menjadi kunci keberhasilan pengobatan.
Estética de la liberación en las teatralidades feministas latinoamericanas
Authors: Proaño Gomez Lola 
Published: January 2024

Expondremos los rasgos de La Estética de la Liberación para luego observar los diversos aspectos liberadores que emergen en las teatralidades feministas latinoamericanas y que justifican clasificarla como tal. Con una perspectiva hermenéutica feminista que sitúa los productos teatrales inmersos en un contexto amplio, interrelacionados con aspectos filosóficos, políticos, económicos y sociales, pretendemos alcanzar no solo su entendimiento sino su comprensión (Gadamer), para observar cómo ellos pueden entenderse como aparatos liberadores. Estas teatralidades, como lo hace el feminismo popular latinoamericano, plantean la existencia del nudo teórico entre capitalismo-patriarcado-neoliberalismo y desnudan escénicamente algunas de sus consecuencias: la violencia de género y la esencialidad del binarismo; la división entre público y privado; el reclamo por los derechos negados y el ingreso del sujeto femenino al mundo simbólico del lenguaje junto con la revaloración del cuerpo no normado como espacio de significación. Algunas respuestas desde la resistencia y la búsqueda de liberación de estas teatralidades son la ocupación del espacio público originalmente negado al sujeto mujer(es); la aparición de un nuevo sujeto, a veces colectivo, plural y constituyente, como es el caso de los grupos artivistas; la integración del cuerpo menospreciado por la tradición filosófica, que, en estas teatralidades es la herramienta fundamental para instalar sus demandas, el territorio en el que se inscribe la lucha. Ejemplificaré la propuesta con producciones teatrales en las que emerge una racionalidad que se diferencia de la racionalidad abstracta masculina[1], una racionalidad que integra una nueva jerarquía de valores y con una lógica cuyo valor supremo es la vida. Todas estas características conforman una política liberadora respecto del régimen hegemónico patriarcal-capitalista-neoliberal y buscan una mejor vida para los sujetos no masculinos mediante diversas técnicas teatrales y performáticas.
Palabras clave: Feminismo; teatralidades; liberación; estética; racionalidad

[1] Esta masculinidad abstracta no da importancia a la realidad material del espacio de la reproducción situado fuera del mundo masculino y esta es la base del dualismo: abstracto/concreto; mente/cuerpo/; cultura/naturaleza; ideal/real, en el que se valora el primer elemento por sobre el segundo asignado al sujeto femenino. La construcción “femenina” alternativa va en contra de los dualismos: valora lo concreto, conexión y continuidad con los otros (gestación y crianza) y la unidad entre mente/cuerpo.
Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle
Authors: Hu Yi , Fang Biqing , Tian Xu , Wang Haiwei , Tian Xiangyang , Yu Fangfang , Li Tao , Yang Zhijie , Shi Rengfei 
Published: January 2024

BackgroundPostmenopausal women are more prone to develop muscle weakness, which is strongly associated with impairment of mitochondrial function in skeletal muscle. This study aimed to examine the impact of a passive exercise modality, whole-body vibration training (WBVT), on muscle mitochondrial function in ovariectomized (OVX) mice, in comparison with 17β-estradiol (E2) replacement.MethodsFemale C57BL/6J mice were assigned to four groups: sham operation control group (Sham), ovariectomized group (OVX), OVX with E2 supplement group (OVX+E), and OVX with WBVT group (OVX+W). The estrous cycle, body weight, body composition, and muscle strength of the mice were monitored after the operation. Serum E2 level was assessed by enzyme-linked immunosorbent assay (ELISA). The ATP levels were determined using a luciferase-catalyzed bioluminescence assay. The activity of mitochondrial respiration chain complexes was evaluated using high-resolution respirometry (O2K). Expression levels of oxidative phosphorylation (OXPHOS), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and mitochondrial transcription factor A (TFAM) were detected using western blotting.ResultsWe observed decreased muscle strength and impaired mitochondrial function in the skeletal muscle of OVX mice. The vibration training alleviated these impairments as much as the E2 supplement. In addition, the vibration training was superior to the ovariectomy and the estradiol replacement regarding the protein expression of PGC-1α and TFAM.ConclusionWBVT improves the OVX-induced decline in muscle strength and impairment of mitochondrial function in the skeletal muscle. This passive exercise strategy may be useful as an alternative to E2 replacement for preventing menopausal muscular weakness. Further studies are needed to understand the effects of WBVT on various physiological systems, and precautions should be taken when implementing it in patient treatment.
Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies
Authors: Cai Yao , Deng Zhirong , Yang Qiuping , Pan Guixian , Liang Zao , Yang Ximei , Song Jie , Xiao Xin , Li Sitao 
Published: January 2024

IntroductionPregnancy outcomes of patients with systemic lupus erythematosus (SLE) have improved over the past four decades, leading to an increased desire for pregnancy among this cohort. However, the offspring of patients with SLE still face the risks of preterm birth, low birth weight, learning disabilities, and neurological disorders, while the causes underlying these risks remain unclear.MethodsIn this study, we analyzed the blood metabolic features of neonates born to 30 SLE patients and 52 healthy control mothers by employing tandem mass spectrometry with the dual aims of identifying the etiology of metabolic features specific to infants born from mothers with SLE and providing new insights into the clinical management of such infants.ResultsWe found significant differences in serum metabolite levels between infants born from mothers with SLE and those born from mothers without SLE, including 15 metabolites with reduced serum levels. Further analysis revealed a disrupted tyrosine metabolism pathway in the offspring of mothers with SLE.DiscussionBy constructing a composite model incorporating various factors, such as serum tyrosine levels, gestational age, and birth weight, we were able to accurately differentiate between newborns of SLE and non-SLE pregnancies. Our data reveal significant differences in serum concentrations of amino acids and acylcarnitines in newborns born to mothers with SLE. We conclude that the reduction of blood L-tyrosine levels is a feature that is characteristic of adverse neurological outcomes in infants born from mothers with SLE.
Automated detection of MRI-negative temporal lobe epilepsy with ROI-based morphometric features and machine learning
Authors: Yang Lin , Peng Bo , Gao Wei , A Rixi , Liu Yan , Liang Jiawei , Zhu Mo , Hu Haiyang , Lu Zuhong , Pang Chunying , Dai Yakang , Sun Yu 
Published: January 2024

ObjectiveTemporal lobe epilepsy (TLE) predominantly originates from the anteromedial basal region of the temporal lobe, and its prognosis is generally favorable following surgical intervention. However, TLE often appears negative in magnetic resonance imaging (MRI), making it difficult to quantitatively diagnose the condition solely based on clinical symptoms. There is a pressing need for a quantitative, automated method for detecting TLE.MethodsThis study employed MRI scans and clinical data from 51 retrospective epilepsy cases, dividing them into two groups: 34 patients in TLE group and 17 patients in non-TLE group. The criteria for defining the TLE group were successful surgical removal of the epileptogenic zone in the temporal lobe and a favorable postoperative prognosis. A standard procedure was used for normalization, brain extraction, tissue segmentation, regional brain partitioning, and cortical reconstruction of T1 structural MRI images. Morphometric features such as gray matter volume, cortical thickness, and surface area were extracted from a total of 20 temporal lobe regions in both hemispheres. Support vector machine (SVM), extreme learning machine (ELM), and cmcRVFL+ classifiers were employed for model training and validated using 10-fold cross-validation.ResultsThe results demonstrated that employing ELM classifiers in conjunction with specific temporal lobe gray matter volume features led to a better identification of TLE. The classification accuracy was 92.79%, with an area under the curve (AUC) value of 0.8019.ConclusionThe method proposed in this study can significantly assist in the preoperative identification of TLE patients. By employing this method, TLE can be included in surgical criteria, which could alleviate patient symptoms and improve prognosis, thereby bearing substantial clinical significance.
Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping
Authors: Chen Zheping , Shan Guoliang , Wang Xinyue , Zuo Yaqun , Song Xinyu , Ma Yufeng , Zhao Xin , Jin Yanwu 
Published: January 2024

BackgroundTau, a microtubule-associated protein extensively distributed within the central nervous system (CNS), exhibits close associations with various neurodegenerative disorders. Here, we aimed to conduct a qualitative and quantitative bibliometric study of the top 100 most-cited publications on tau protein and reveal the current research hotspots and future perspectives.MethodsThe relevant literature was retrieved from the Web of Science Core Collection. CiteSpace (v6.2.R4) and VOSviewer (1.6.19) were adopted for bibliometric analysis with statistical and visual analysis.ResultsCitations per article ranged from 615 to 3,123, with a median number of 765.5 times. “Neuroscience” emerged as the most extensively researched subject in this field. The USA has emerged as the leading country, with a publication record (n = 65), total citations (n = 66,543), strong centrality (0.29), and extensive international collaborations. Harvard University (n = 11) and the University of California, San Francisco (n = 11) were the top two institutions in terms of publications. Neuron dominated with 13 articles in the 37 high-quality journals. M. Goedert from the MRC Laboratory of Molecular Biology was the most productive (n = 9) and top co-cited (n = 179) author. The most frequently studied keywords were Alzheimer’s disease (n = 38). Future research is anticipated to intensify its focus on the pathogenesis of various tau-related diseases, emphasizing the phosphorylation and structural alterations of tau protein, particularly in Alzheimer’s disease.ConclusionThe pathogenesis of various tau-related diseases, including the phosphorylation and structural alterations of the tau protein, will be the primary focus of future research, with particular emphasis on Alzheimer’s disease as a central area of investigation.
Outcomes and complications of postoperative seroma cavities following soft-tissue sarcoma resection
Authors: Andryk Logan M. , Neilson John C. , Wooldridge Adam N. , Hackbarth Donald A. , Bedi Meena , Baynes Keith E. , LoGiudice John A. , Slusarczyk Sonia M. , King David M. 
Published: January 2024

IntroductionSeroma development is a known complication following extremity and trunk soft-tissue sarcoma (STS) resection. The purpose of this study is to evaluate and characterize seroma outcomes and the development of associated complications.MethodsA retrospective review of 123 patients who developed postoperative seromas following STS resection at a single institution was performed. Various patient and surgical factors were analyzed to determine their effect on overall seroma outcomes.Results77/123 seromas (62.6%) were uncomplicated, 30/123 (24.4%) developed infection, and 16/123 (13.0%) were symptomatic and required aspiration or drainage for symptom relief at an average of 12.2 months postoperatively. 65/123 (52.8%) seromas resolved spontaneously at an average time of 12.41 months. Seromas in the lower extremity (p=0.028), surgical resection volume &gt;864 cm3, (p=&lt;0.001) and initial seroma volume &gt;42 cm3 (p=&lt;0.001) increased the likelihood of infection. 90% of infected seromas developed the infection within the first three months following initial resection. No seromas which were aspirated or drained ultimately developed an infection following these procedures, though 50% recurred. DiscussionMost seromas following STS resection are uncomplicated and do not require intervention, though a large resection cavity &gt;864 cm3 and a large seroma volume &gt;42 cm3 are risk factors for complications.
Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia
Authors: Al-Swailem Samar A. , Alkatan Hind M. , AlDhaheri Huda Saif , AlHilali Sara M. , Maktabi Azza M. Y. 
Published: January 2024

PurposeTo report clinical features and treatment outcome of three cases with isolated corneal intraepithelial neoplasia (CIN).MethodsThis case series presents 3 patients with isolated CIN. Data collected included, presenting signs and symptoms including vision, anterior segment examination, medical and surgical outcomes and signs and symptoms at lost post-treatment visit.ResultsCase 1 was a 45-year-old male who presented with an isolated grayish amoeboid corneal lesion which was excised with alcohol assisted epitheliectomy, he also received 6 cycles of topical mitomycin C (MMC) 0.02% and one injection of interferon alfa-2b with no recurrence during the 10-year follow-up period. Case 2 was 78-year-old male referred for a suspicious white corneal lesion which was completely excised, the patient also received 6 subconjunctival injections of interferon alpha-2b. However, the lesion recurred at 2.5-years post-treatment. Case 3 was a 63-year-old male patient who presented with an isolated corneal lesion that was excised using alcohol-assisted epitheliectomy, patient received four cycles of topical 5-fluorouracil with no recurrence at last follow-up visit at 6 months.ConclusionIsolated corneal intraepithelial neoplasia (CIN) is a rare entity with few reported cases in the literature. In this case series, we report long and short-term management outcomes of combined surgical and medical therapy for isolated CIN.
Technical performance scores associate with early prognosis of tetralogy of Fallot repair
Authors: Alifu Ailixiati , Wang Haifan , Chen Renwei 
Published: January 2024

ObjectiveThis study aimed to investigate the relationship between technical performance scores (TPS) and the early prognosis of tetralogy of Fallot repair (TOF).MethodsA retrospective study was conducted on TOF repair patients at our center from Oct 2017 to Oct 2022. Patients were classified into Class 1 (no residua), Class 2 (minor residua), or Class 3 (major residua) based on TPS derived from predischarge echocardiograms and need for reintervention. Statistical methods were used to assess the association between TPS and early prognosis.ResultsA total of 75 TOF repair patients (40% female, 60% male) were analyzed and categorized into TPS1 (24%), TPS2 (53.3%), and TPS3 (22.6%) based on pre-discharge echocardiographic findings. The median follow-up time was 7.0 months. The multivariable Cox regression analysis indicated that TPS3 scores are associated with a 12.68-fold increase in risk compared to TPS1 and TPS2 scores [95% CI = 12.68 (0.9∼179.28), P = 0.06]. The Spearman rank correlation analysis revealed a weak positive correlation between TPS classification and low cardiac output syndrome (r = 0.26, P = 0.03). However, there were no significant differences in ICU stay or duration of mechanical ventilation among the groups.ConclusionTPS3 after intracardiac TOF repair is associated with higher risk of early re-intervention, highlighting the importance of close follow-up and monitoring in this patient population. Patients who develop low cardiac output syndrome in the early postoperative period may have residual defects that require prompt identification.
Is the current therapeutic dosage of nadroparin adequate for neonates and infants under 8 months with thromboembolic disease? a population pharmacokinetic study from a national children’s medical center
Authors: Chen Yewei , Lan Jianger , Zhu Lin , Dong Min , Wang Yi , Li Zhiping 
Published: January 2024

Objectives: Nadroparin, a low-molecular-weight-heparin is commonly used off-label in neonates and infants for thromboembolic events prevention. However, the recommended dosing regimen often fails to achieve therapeutic target ranges. This study aimed to develop a population pharmacokinetic (PK) model of nadroparin to determine an appropriate dosing regimen for neonates and infants less than 8 months.Methods: A retrospective chart review was conducted on patients treated with nadroparin at Children’s Hospital of Fudan University between July 2021 and December 2023. A population PK model was developed using anti-Xa levels, and its predictive performance was evaluated internally. Monte Carlo simulations were performed to design an initial dosing schedule targeting anti-Xa levels between 0.5 and 1 IU/mL.Results: A total of 40 neonates and infants aged less than 8 months with gestational age ranging from 25 to 41 weeks treated with nadroparin were enrolled in the study for analysis. A one-compartment PK model with first order absorption and elimination was adequately fitted to the data. Creatinine clearance was identified as a significant factor contributing to inter-individual variability in clearance. The typical population parameter estimates of clearance, distribution volume and absorption rate in this population were 0.211 L/h, 1.55 L and 0.495 h-1, respectively. Our findings suggest that current therapeutic doses of nadroparin (150–200 IU/kg q12 h) may result in subtherapeutic exposure, thus higher doses might be required.Conclusion: The present study offers the first estimation of PK parameters for nadroparin in preterm or term neonates and infants less than 8 months utilizing the model. Our findings have potential implications for recommending initial personalized dosages, particularly among patient populations exhibiting similar characteristics.
Assessing the stress-relief impact of an art-based intervention inspired by the broaden-and-build theory in college students
Authors: Liu Chen , Xie Yuan , Xu Yiwen , Song Zhenhai , Tang Jiayi , Shen Junjie , Jiang Zhou , Shen Chao , Zhan Xingya , Zheng Chu 
Published: January 2024

Background and objectivesThis study’s primary objective is to investigate the impact of art-making on the mental well-being of college students, who often experience heightened stress during their initial university years.MethodsEmploying a comprehensive methodology, combining interviews and the Perceived Stress Scale (PSS), the research aimed to assess whether a four-week art-making intervention can effectively alleviate stress levels among college students. In the experimental group, participants engaged in a variety of art-making activities, including freehand drawing, clay modeling, and crafting.ResultsThe results revealed that, in the pre-test, there were no significant differences between the experimental and control groups for each assessed indicator. However, in the post-test, significant differences emerged across all indicators. Further analysis demonstrated a significant reduction in stress perception among the experimental group participants between the pre-test and post-test phases.ConclusionIn conclusion, this study provides compelling evidence that art-making has the potential to foster positive personal development and significantly reduce stress levels among college students.