bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comment on “Reflections on patient engagement by patient partners: How it can go wrong”
Authors: Zaratin Paola , Khan Usman , Graffigna Guendalina 
Published: December 2023

AbstractAs patient-advocacy, public policy and clinical researchers with special knowledge on Responsible Research Innovation (RRI) governance and the public health and psychology underlying patient engagement, we read with interest the comment contribution by Richards et al., “Reflections on patient engagement by patient partners: How it can go wrong” (Richards et al. in Res Involv Engagem 9:41, 2023. https://doi.org/10.1186/s40900-023-00454-13). As a way to help meet the “take-away actions for readers” included by the authors at the end of the article, we would like to further stimulate discussion with relevant stakeholder communities about the need to rethink the use of “expert patient”. Based on our experience, the lack of a governance model engaging patients who are representative of the target patient community, as opposed to expert patients, is at the root of the tokenistic approach, the “patient partner as a checkmark statement” and the “lack of recognizing the vulnerability of patient partners”, which results in “patient engagement going wrong”. According to our experience, the Responsible Research Innovation (RRI) MULTI-ACT model has the potential to help meet these challenges.
Exploration of Metabolomic Markers Associated With Declining Kidney Function in People With Type 2 Diabetes Mellitus
Authors: Krasauskaite Justina , Conway Bryan , Weir Christopher , Huang Zhe , Price Jackie 
Published: December 2023

AbstractBackgroundMetabolomics, the study of small molecules in biological systems, can provide valuable insights into kidney dysfunction in people with type 2 diabetes mellitus (T2DM), but prospective studies are scarce. We investigated the association between metabolites and kidney function decline in people with T2DM.MethodsThe Edinburgh Type 2 Diabetes Study, a population-based cohort of 1066 men and women aged 60 to 75 years with T2DM. We measured 149 serum metabolites at baseline and investigated individual associations with baseline estimated glomerular filtration rate (eGFR), incident chronic kidney disease [CKD; eGFR &lt;60 mL/min/(1.73 m)2], and decliner status (5% eGFR decline per year).ResultsAt baseline, mean eGFR was 77.5 mL/min/(1.73 m)2 (n = 1058), and 216 individuals had evidence of CKD. Of those without CKD, 155 developed CKD over a median 7-year follow-up. Eighty-eight metabolites were significantly associated with baseline eGFR (β range −4.08 to 3.92; PFDR &lt; 0.001). Very low density lipoproteins, triglycerides, amino acids (AAs), glycoprotein acetyls, and fatty acids showed inverse associations, while cholesterol and phospholipids in high-density lipoproteins exhibited positive associations. AA isoleucine, apolipoprotein A1, and total cholines were not only associated with baseline kidney measures (PFDR &lt; 0.05) but also showed stable, nominally significant association with incident CKD and decline.ConclusionOur study revealed widespread changes within the metabolomic profile of CKD, particularly in lipoproteins and their lipid compounds. We identified a smaller number of individual metabolites that are specifically associated with kidney function decline. Replication studies are needed to confirm the longitudinal findings and explore if metabolic signals at baseline can predict kidney decline.
Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri
Authors: Torraca Vincenzo , White Richard J. , Sealy Ian M. , Mazon-Moya Maria , Duggan Gina , Willis Alexandra R. , Busch-Nentwich Elisabeth M. , Mostowy Serge 
Published: December 2023

ABSTRACT
Shigella flexneri is a human-adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. flexneri has not been fully described. Zebrafish larvae represent a valuable model for studying human infections in vivo. Here, we use a Shigella-zebrafish infection model to generate mRNA expression profiles of host response to Shigella infection at the whole-animal level. Immune response-related processes dominate the signature of early Shigella infection (6 h post-infection). Consistent with its clearance from the host, the signature of late Shigella infection (24 h post-infection) is significantly changed, and only a small set of immune-related genes remain differentially expressed, including acod1 and gpr84. Using mutant lines generated by ENU, CRISPR mutagenesis and F0 crispants, we show that acod1- and gpr84-deficient larvae are more susceptible to Shigella infection. Together, these results highlight the power of zebrafish to model infection by bacterial pathogens and reveal the mRNA expression of the early (acutely infected) and late (clearing) host response to Shigella infection.
Treat, Dump, or Export? How Domestic and International Waste Management Policies Shape Waste Chain Outcomes
Authors: Wijnsma Sytske C. , Lauga Dominique Olié , Toktay L. Beril 
Published: December 2023

Illegal or unwanted waste disposal methods such as dumping and export are prevalent in practice. To minimize the environmental harm of these methods, policymakers have implemented laws and regulations designed to combat them. Even so, violations are rampant as a high degree of heterogeneity between firms and proprietary information render monitoring imperfect. Decentralized waste disposal chains, a common form of interbusiness organization in this sector, compound this problem as firms also have limited information available on their waste chain partner, creating complex interactions between firm behavior and policy interventions. Against this background, we analyze the effects of domestic and international waste regulations targeting dumping and export, respectively, on firm incentives and compliance. We develop a two-tier waste chain with a producer that generates waste and an operator that treats it. The producer’s waste quality and the treatment operator’s efficiency can be private information. Either party can avoid compliance cost by violating regulations where the producer can arrange for export and the operator can dump locally. Our analysis reveals that primarily focusing on penalizing dumping by treatment operators can worsen environmental harm. Solely focusing on penalizing low-quality waste exports, a common intervention in practice, can also backfire. Instead, penalizing producers for downstream dumping should be given consideration. In addition, the asymmetry in export burden between waste quality levels should be reduced. This paper was accepted by Vishal Gaur, operations management.
Inventory Productivity and Stock Returns in Manufacturing Networks
Authors: Agrawal Deepak , Osadchiy Nikolay 
Published: December 2023

Problem definition: We provide a novel, supply network-based perspective on inventory productivity and incentives for its improvement. Methodology/results: Using data from 2003 to 2019, we find that inventory productivity is lower materially and statistically for firms located upstream in the supply network, and higher for high degree and more central firms. Firms with high inventory productivity show high equity valuations and abnormal returns, with both valuations and abnormal returns amplified for upstream, low degree, and peripheral firms. Moreover, the difference in valuations and abnormal returns between best and worst performing firms is greater upstream, suggesting that financial markets offer outsized rewards for improving inventory productivity to upstream firms. Managerial implications: We show that the information about firm’s upstreamness and centrality in the supply network is a valuable predictor of its inventory productivity and financial performance. Our methods for evaluating upstreamness are useful for that purpose. For operations managers and firm executives, our results highlight strong incentives for inventory productivity improvement upstream in the supply network. For investors, we show that supply network position data can sharpen inventory-based arbitrage opportunities. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0229 .
Evaluation of response to gemcitabine plus cisplatin-based chemotherapy using positron emission computed tomography for metastatic bladder cancer
Authors: Öztürk Hakan , Karapolat İnanç 
Published: December 2023

BACKGROUND
The purpose of the present study was to examine retrospectively the contribution of 18Fluorodeoxyglucose positron emission tomography computed tomography (18FDG-PET/CT) to the evaluation of response to first-line gemcitabine plus cisplatin-based chemotherapy in patients with metastatic bladder cancer.
AIM
To evaluate the response to Gemcitabine plus Cisplatin -based chemotherapy using 18FDG-PET/CT imaging in patients with metastatic bladder cancer.
METHODS
Between July 2007 and April 2019, 79 patients underwent 18FDG-PET/CT imaging with the diagnosis of Metastatic Bladder Carcinoma (M-BCa). A total of 42 patients (38 male, 4 female) were included in the study, and all had been administered Gemcitabine plus Cisplatin-based chemotherapy. After completion of the therapy, the patients underwent a repeat 18FDG-PET/CT scan and the results were compared with the PET/CT findings before chemotherapy according to European Organisation for the Research and treatment of cancer criteria. Mean age was 66.1 years and standard deviation was 10.7 years (range: 41–84 years).
RESULTS
Of the patients, seven (16.6%) were in complete remission, 17 (40.5%) were in partial remission, six (14.3%) had a stable disease, and 12 (28.6%) had a progressive disease. The overall response rate was 57.1 percent.
CONCLUSION
18FDG-PET/CT can be considered as a successful imaging tool in evaluating response to first-line chemotherapy for metastatic bladder cancer. Anatomical and functional data obtained from PET/CT scans may be useful in the planning of secondline and thirdline chemotherapy.
Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale
Authors: Stoyanov Drozdstoy , Paunova Rositsa , Dichev Julian , Kandilarova Sevdalina , Khorev Vladimir , Kurkin Semen 
Published: December 2023

BACKGROUND
Our study expand upon a large body of evidence in the field of neuropsychiatric imaging with cognitive, affective and behavioral tasks, adapted for the functional magnetic resonance imaging (MRI) (fMRI) experimental environment. There is sufficient evidence that common networks underpin activations in task-based fMRI across different mental disorders.
AIM
To investigate whether there exist specific neural circuits which underpin differential item responses to depressive, paranoid and neutral items (DN) in patients respectively with schizophrenia (SCZ) and major depressive disorder (MDD).
METHODS
60 patients were recruited with SCZ and MDD. All patients have been scanned on 3T magnetic resonance tomography platform with functional MRI paradigm, comprised of block design, including blocks with items from diagnostic paranoid (DP), depression specific (DS) and DN from general interest scale. We performed a two-sample t -test between the two groups-SCZ patients and depressive patients. Our purpose was to observe different brain networks which were activated during a specific condition of the task, respectively DS, DP, DN.
RESULTS
Several significant results are demonstrated in the comparison between SCZ and depressive groups while performing this task. We identified one component that is task-related and independent of condition (shared between all three conditions), composed by regions within the temporal (right superior and middle temporal gyri), frontal (left middle and inferior frontal gyri) and limbic/salience system (right anterior insula). Another component is related to both diagnostic specific conditions (DS and DP) e.g. It is shared between DEP and SCZ, and includes frontal motor/language and parietal areas. One specific component is modulated preferentially by to the DP condition, and is related mainly to prefrontal regions, whereas other two components are significantly modulated with the DS condition and include clusters within the default mode network such as posterior cingulate and precuneus, several occipital areas, including lingual and fusiform gyrus, as well as parahippocampal gyrus. Finally, component 12 appeared to be unique for the neutral condition. In addition, there have been determined circuits across components, which are either common, or distinct in the preferential processing of the sub-scales of the task.
CONCLUSION
This study has delivers further evidence in support of the model of trans-disciplinary cross-validation in psychiatry.
Cholecystoenteric fistula in a patient with advanced gallbladder cancer: A case report and review of literature
Authors: Wang Chun-Yu , Chiu Sung-Hua , Chang Wei-Chou , Ho Meng-Hsing , Chang Ping-Ying 
Published: December 2023

BACKGROUND
Cholecystoenteric fistula (CEF) involves the formation of a spontaneous anomalous tract between the gallbladder and the adjacent gastrointestinal tract. Chronic gallbladder inflammation can lead to tissue necrosis, perforation, and fistulogenesis. The most prevalent cause of CEF is chronic cholelithiasis, which rarely results from malignancy. Because the symptoms and laboratory findings associated with CEF are nonspecific, the condition is often misdiagnosed, presenting a challenge to the surgeon when detected intraoperatively. Therefore, a preoperative diagnosis of CEF is crucial.
CASE SUMMARY
We present the case of a 57-year-old male with advanced gallbladder cancer (GBC) who arrived at the emergency room with persistent vomiting, abdominal pain, and diarrhea. An abdominopelvic computed tomography scan revealed a contracted gallbladder with bubbles in the fundus connected to the second portion of the duodenum and transverse colon. We suspected that GBC had invaded the adjacent gastrointestinal tract through a cholecystoduodenal fistula (CDF) or a cholecystocolonic fistula (CCF). He underwent multiple examinations, including esophagogastroduodenoscopy, an upper gastrointestinal series, colonoscopy, and magnetic resonance cholangiopancreatography; the results of these tests confirmed a diagnosis of synchronous CDF and CCF. The patient underwent a Roux-en-Y gastrojejunostomy and loop ileostomy to address the severe adhesions that were previously observed to cover the second portion of the duodenum and hepatic flexure of the colon. His symptoms improved with supportive treatment while hospitalized. He initiated oral targeted therapy with lenvatinib for further anticancer treatment.
CONCLUSION
The combination of imaging and surgery can enhance preoperative diagnosis and alleviate symptoms in patients with GBC complicated by CEF.
Intraperitoneal hyaline vascular Castleman disease: Three case reports
Authors: Gao Jia-Wei , Shi Zhe-Yi , Zhu Zhao-Bi , Xu Xiang-Rong , Chen Wei 
Published: December 2023

BACKGROUND
Castleman disease (CD) was first reported in 1954. It is a rare non-malignant lymphoproliferative disease with unclear etiology. As the clinical manifestations of CD are different, there are difficulties in its diagnosis and treatment. Therefore, for patients with CD, it is important to establish the diagnosis in order to choose the appropriate treatment.
CASE SUMMARY
In this report, three patients with intraperitoneal CD treated at our center from January 2018 to June 2023 were reviewed, and the clinical and paraclinical examinations, diagnosis, and treatment were analyzed, and all three patients were diagnosed with CD by routine histopathological and immunohistochemical examinations.
CONCLUSION
CD is a complex and rare disease. Because there are no special clinical symptoms and laboratory abnormalities, the diagnosis often depends on routine pathological and immunohistochemical findings.
Empreendedorismo e Sua Relação Com a Educação Financeira dos Universitários
Authors: Sauer Camozzato Elen , Lizote Suzete Antonieta , Teston Sayonara de Fátima , Zawadzki Patrick 
Published: December 2023

Este estudo teve como objetivo avaliar o relacionamento entre a intenção empreendedora de estudantes universitários com sua educação financeira. Buscou também avaliar se as disciplinas de empreendedorismo e finanças aumentam sua intenção empreendedora e educação financeira, respectivamente. Para tanto, foi feita uma pesquisa descritiva com abordagem quantitativa, realizando-se uma survey com os alunos do curso de Administração de todos os níveis de três Instituições de Ensino Superior da Região Sul do Brasil. A amostra esteve composta por 420 estudantes. Para o processamento dos dados, utilizou-se a Análise Fatoria Exploratória, Análise Fatorial Confirmatória e Análise de Variância. Os resultados apontaram que a hipótese que testou se os alunos que cursaram disciplina de empreendedorismo têm uma maior intenção empreendedora não foi confirmada, já aquela que verificou se aqueles que cursaram disciplinas relacionadas com finanças têm uma maior educação financeira confirmou-se. Não foi confirmada a relação entre os constructos para a amostra completa, mas quando desagregada por estado se constatou que a educação financeira influencia positivamente a intenção empreendedora nos alunos do Paraná.
Effects of methotrexate, <em>Moringa oleifera</em>, and <em>Andrographis paniculata</em> extracts on the myocardial and aortic tissue of streptozotocin-nicotinamide-induced hyperglycemic rats
Authors: Pamungkas Dimas Bathoro Bagus , Kalanjati Viskasari Pintoko , Abdurachman  , Aditya Dwi Martha Nur , Nasution Muhammad Husni Fansury , Syamhadi Maya Rahmayanti 
Published: December 2023

BACKGROUND Methotrexate (MTX) could lower glucose levels in type 1 diabetes mellitus, while Moringa oleifera and Andrographis paniculata supplementations have similar effects on hyperglycemia. This study aimed to analyze the effects of MTX, M. oleifera, and A. paniculata leaf extracts on the myocardial interleukin (IL)-6 and the histopathology of the left ventricle and aorta.
METHODS 49 rats were divided equally into 7 groups: negative control and diabetic induced by streptozotocin-nicotinamide (STZ-NA) injection consisting of positive control (STZ-NA only), M. oleifera (500 mg/kgBW/day), A. paniculata (500 mg/kgBW/day), MTX (7 mg/kgBW/week), MTX (7 mg/kgBW/week)+M. oleifera (500 mg/kgBW/day), and MTX (7 mg/kgBW/week)+A. paniculata (500 mg/kgBW/day). We analyzed oral MTX, M. oleifera, and A. paniculata leaf extracts’ effects on random blood glucose, myocardial IL-6, and cardiac histopathology of STZ-NA-induced hyperglycemic male rats. Data were analyzed using Wilcoxon and Kruskal–Wallis tests.
RESULTS Myocardial IL-6 in the M. oleifera group was significantly lower compared to the positive control group (p = 0.041). Compared to the positive control group, the myocardial necrosis and aortic intima–media thickness in the MTX+A. paniculata group were significantly reduced (p = 0.005 and 0.001, respectively).
CONCLUSIONS MTX, M. oleifera, and A. paniculata showed antihyperglycemic effect, both individually and in combination. A. paniculata leaf extract had a significant cardioprotective effect in STZ-NA-induced hyperglycemia.
Multi-channel synthetic aperture infrared imaging and experimental research
Authors: Wu J. , Li D. , Gao J. , Cui A. , Li R. , Wu S. 
Published: December 2023

The synthetic aperture infrared radio imaging method based on laser local oscillator coherent detection has potential application value for astronomical observations. This paper studies the multi-channel synthetic aperture infrared imaging method and conducts experimental verification using a principle prototype. In the short-wave infrared band, five beam-expanding fiber collimators are used to build an observation structure of five laser local oscillator coherent detection channels at a near-field distance of 5 m to carry out physical experiments. The laser local oscillator wavelength is 1.55 µm, and the AD sampling rate is 4 GHz. For the infrared radiation source signal, the phase relationship of the infrared signals between channels acquired by the prototype principle is stable, and the five-channel synthetic aperture imaging results are consistent with the computer simulated results. The experiment verified the effectiveness of the laser local oscillator comprehensive aperture infrared radio imaging method.
Universal silicon ring resonator for error-free transmission links
Authors: Zhu Junbo , Zhang Weiwei , Li Ke , Pant Bharat , Ebert Martin , Yan Xingzhao , Banakar Mehdi , Tran Dehn T. , Littlejohns Callum G. , Gan Fuwan , Reed Graham , Thomson David J. 
Published: December 2023

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of ∼4  V·mm and >8  dB optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate ≤3×10−12. Individually, the speed of modulation and detection is measured up to 112 Gb/s and 80 Gb/s, respectively. The principle of co-designing the PN junction ring modulator and detector performance required for error-free communication links can significantly ease the fabrication yield challenges of ring structures by reducing the number of types of devices. The principle can also be applied to O band wavelengths. To the best of our knowledge, for the first time, a device of this type has achieved both error-free modulation and detection operation up to 50 Gb/s in the C band individually or in conjugation as an error-free communication link, which paves the way to realize a >1.6  Tb/s all-silicon WDM-based error-free optical transceiver link in the future and is essential for future programmable photonics circuits.
Eine Taxonomie zur Rollendefinition von Chief Digital Officers im Zeitalter der Digitalen Transformation
Authors: Höhener Daria 
Published: December 2023

ZusammenfassungDie Anforderungen an einen Chief Digital Officer (CDO) unterliegen Veränderungen und die Ausgestaltung dieser Rolle nimmt je nach organisationaler Struktur eine unterschiedliche Bedeutung an. Die CDO-Rollentaxonomie dient Unternehmen als nützliches Werkzeug, um die Integration dieser Rolle in die organisatorischen Gegebenheiten zu vollziehen und die erforderlichen Kompetenzen und Aufgabenbereiche (zum Beispiel bei der Neuausschreibung des Profils) festzulegen. Die Taxonomie basiert auf dem adaptierten Extended Taxonomy Design Process (ETDP). Dies ermöglicht einen zugleich wissenschaftlich basierten und praxisorientierten Blick auf die benötigten Kompetenzen eines CDOs im Kontext der Digitalen Transformation.Aufbauend auf einer Literature Review wurden Dimensionen und Charakteristiken, gemäß den initialien Meta-Charakteristiken, den Managerrollen von Mintzberg, geclustert. In drei Iterationszyklen wurde die Taxonomie erarbeitet und mit Erkenntnissen aus Stellenbeschreibungen ergänzt. Die Evaluierung erfolgte durch Interviews mit Praktikern aus dem Executive Search Bereich.Der wissenschaftliche Praxisbeitrag macht die CDO-Rolle mittels einer Taxonomie, die mit vier Meta-Charakteristiken, neun Dimensionen und insgesamt 26 spezifischen Charakteristiken ausgestaltet ist, fassbar. Die einzelnen Charakteristiken sind dabei den Meta-Ebenen organisatorisch, entscheidungsrelevant, interpersonell und informativ zugeordnet, was eine strukturierte und zielorientierte Rollendefinition erleichtert.