bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KESESUAIAN FATWA DSN-MUI NO. 77/DSN-MUI/V/2010 TERHADAP PEMBIAYAAN MURABAHAH CICIL EMAS
Authors: Wibawa Ginan , Rifada Rizqi Alda , Faroha Diar , Oktaviani Rianti 
Published: October 2023

Melihat perkembangan zaman saat ini, pembiayaan kepemilikan emas semakin banyak diminati oleh masyarakat dengan pembayaran dicicil. Oleh karena itu, lembaga-lembaga keuangan syariah mulai meluncurkan sebuah produk pembiayaan murabahah emas dalam bentuk jual beli tidak tunai. Sepintas tidak ada masalah dengan jual beli emas secara tidak tunai ini, namun praktik tersebut justru bertolak belakang dengan hadits Nabi Saw. dan mendapatkan pertentangan dari berbagai pendapat mayoritas fuqaha dan ulama kontemporer lainnya. Namun dalam fatwa DSN-MUI No. 77/DSN-MUI/V/2010 tentang jual beli emas secara tidak tunai dinyatakan bahwa jual beli emas secara tunai itu boleh (Mubah, jaiz). Penelitian ini merupakan jenis penelitian kepustakaan (Library Research) dengan menggunakan pendekatan deskriptif analisis yang berupa pencarian fakta, hasil dan ide pemikiran seseorang melalui cara mencari, menganalisis, membuat interpretasi serta melakukan generalisasi terhadap hasil penelitian yang dilakukan. Hasil penelitian menunjukan bahwa alasan diperbolehkannya jual beli emas secara tidak tunai ini karena merujuk pada Fatwa DSN-MUI dengan menggunakan dasar hukum dari pendapat ulama-ulama kontemporer yang membolehkan. Namun, fatwa tersebut dilemahkan oleh ulama kontemporer seperti Erwandi Tarmizi dengan menyatakan bahwa fatwa tersebut masih dipertanyakan istinbat hukum Islamnya.
How Periodontitis or Periodontal Bacteria Can Influence Alzheimer’s Disease Features? A Systematic Review of Pre-Clinical Studies
Authors: Salhi Leila , Al Taep Yaman , Salmon Eric , Van Hede Dorien , Lambert France 
Published: October 2023

Background: The negative effects of periodontitis on systemic diseases, including diabetes, cardiovascular diseases, and Alzheimer’s disease (AD), have been widely described. Objective: This systematic review aimed to gather the current understanding of the pathophysiological mechanisms linking periodontitis to AD. Methods: An electronic systematic search of the PubMed/MEDLINE, Scopus, and Embase databases was performed using the following PECO question: How can periodontitis or periodontal bacteria influence Alzheimer’s disease features?”. Only preclinical studies exploring the biological links between periodontitis and AD pathology were included. This study was registered at the International Prospective Register of Systematic Reviews (PROSPERO), and the Syrcle and Camarades protocols were used to assess the risk of bias. Results: After a systematic screening of titles and abstracts ( n = 3,307), thirty-six titles were selected for abstract reading, of which 13 were excluded (k = 1), resulting in the inclusion of 23 articles. Oral or systemic exposure to periodontopathogens or their byproducts is responsible for both in situ brain manifestations and systemic effects. Significant elevated rates of cytokines and amyloid peptides (Aβ) and derivate products were found in both serum and brain. Additionally, in infected animals, hyperphosphorylation of tau protein, hippocampal microgliosis, and neuronal death were observed. Exposure to periodontal infection negatively impairs cognitive behavior, leading to memory decline. Conclusions: Systemic inflammation and brain metastatic infections induced by periodontal pathogens contribute to neuroinflammation, amyloidosis, and tau phosphorylation, leading to brain damage and subsequent cognitive impairment.
Relationship Between Non-Cognitive Intrinsic Capacity and Activities of Daily Living According to Alzheimer’s Disease Stage
Authors: Fujisawa Chisato , Umegaki Hiroyuki , Sugimoto Taiki , Nakashima Hirotaka , Nagae Masaaki , Komiya Hitoshi , Watanabe Kazuhisa , Yamada Yosuke , Sakurai Takashi 
Published: October 2023

Background: Few studies have examined the relationship between non-cognitive factors and activities of daily living (ADL) according to Alzheimer’s disease (AD) stage. Objective: We aimed to identify the differences in non-cognitive factors according to AD stages and their involvement in basic and instrumental ADL performance by using intrinsic capacity (IC) in groups with cognition ranging from normal to moderate or severe AD. Methods: We enrolled 6397 patients aged≥65 years who visited our memory clinic. Non-cognitive IC was assessed using the locomotion, sensory, vitality, and psychological domains. Multiple logistic regression was performed to identify how non-cognitive IC declines over the AD course and examine the correlation between non-cognitive IC and basic and instrumental ADL performance. Results: Non-cognitive IC declined from the initial AD stage and was significantly correlated with both basic and instrumental ADL performance from the aMCI stage through all AD stages. In particular, the relationship between IC and basic ADL was stronger in mild and moderate to severe AD than in the aMCI stage. On the other hand, the relationship between IC and instrumental ADL was stronger in aMCI than in later AD stages. Conclusions: The results show non-cognitive factors, which decline from the aMCI stage, are correlated with ADL performance from the aMCI stage to almost all AD stages. Considering that the relationship strength varied by ADL type and AD stage, an approach tailored to ADL type and AD stage targeting multiple risk factors is likely needed for effectively preventing ADL performance declines.
FACTORS INFLUENCE THE INTENTION TO USE IN PAYLATER FEATURE AMONG THE MILLENNIAL GENERATION
Authors: Azzahra Kholidah , Mardinawati Mardinawati , Zees Sri Rahayu , Ayundyayasti Prima 
Published: October 2023

<p>These days the use of PayLater has become a trend in society, focusing on the gen z and millennials. This is because digital adoption in significantly higher than the previous generation. Shopee introduced the latest digital credit card payment feature called Shopee PayLater (SPayLater). In this case, the research is carried out on Acceptance and Use Technology in Shopee PayLater feature using UTAUT2 Model. This research aims to analyze the factors that influence the intention to use the PayLater feature on Shopee PayLater using UTAUT2 Model. The data used was obtained from distributing questionnaires with 122 respondents of millennial generation Shopee PayLater users. The data collection technique used is Nonprobability Sampling. The data was processed using SmartPLS 3. The resuts of this study indicate that there are variables that have a significant and no significant effect on the use of Shopee PayLater. The variables of Performance Expectancy, Effort Expectancy, Social Influence, Facilitating Conditions, and Price Value have no significant effect on Behavioral Intention. In addition, the Hedonic Motivation and Habit variables have a significant effect on the Behavioral Intention of using SPayLater. Another result of this research is that Behavioral Intention, Facilitating Conditions, and Habit variables have a significant effect on Use Behavior using Shopee PayLater.</p><p> </p>
PERAN PERGURUAN TINGGI DALAM PENCEGAHAN KEKERASAN DALAM RUMAH TANGGA (KDRT) DI MASA PANDEMI
Authors: Sa'diyah Nur Khalimatus , Enggarsasi Umi , Prameswari Septiana 
Published: October 2023

Based on data released by the Ministry of Women's Empowerment and Child Protection of the Republic of Indonesia (Kemenpppa), the number of cases of Domestic Violence (KDRT) that occurred in Indonesia throughout 2020 was still very high. East Java ranks second highest after Central Java as the province with the most domestic violence cases throughout 2020, with 1,588 cases. This figure is obtained from the number of cases of domestic violence reported in all cities in East Java.
Efforts to reduce the incidence of domestic violence are not enough just to take repressive actions against perpetrators of domestic violence. What is more important is preventive action to prevent the occurrence of domestic violence. One of the causes of domestic violence can occur is the lack of public knowledge about what is meant by domestic violence. Because there are still many cases of domestic violence that occur during this Covid-19 Pandemic. This is where the role of universities is expected to be able to provide knowledge to the community, not only for women or children, but also for men.
One of the things that universities can do in providing knowledge to the community regarding domestic violence is by conducting socialization and legal counseling. The role of legal counseling can provide increased legal knowledge to community members in order to avoid violations of the law, especially Law Number 23 of 2004 concerning the Elimination of Domestic Violence. Another benefit of legal counseling is that the community can play an active role directly with other communities to transmit or relay the relay to other members of the community such as within the family, neighbors, in the neighborhood associations and neighborhood associations in the East Java region.
Keywords: College, Domestic Violence, Pandemic
Pengenalan Higiene dan Sanitasi dalam Pengolahan Kopra Pada Home Industry Kopra Desa Muara Telang Kabupaten Banyuasin
Authors: Handayani Marta Tika Handayani , Riani Ira Gusti , Khairunnisa Eka Nurriza 
Published: October 2023

Muara Telang village is one of the villages in Banyuasin district which produces coconuts. There are many copra processing home industries in the area. One of the copra processing home industries is A'A Yusma's home industry. Copra is processed manually and without regard to higiene and sanitation aspects in copra processing. This is the background for the introduction of higiene and sanitation in copra processing in the copra home industry. The activity was carried out on January 15 2023 offline in the form of training/counseling and was attended by 15-20 people. The activity went smoothly and the community enthusiastically participated in this activity. It is hoped that this activity will raise awareness of the importance of higiene and sanitation in copra processing and apply higiene and sanitation in copra processing.

Keywords: Introduced, Higiene and sanitation, Copra’s industry, Banyuasin.
Wahana Edukasi Kreatif Sebagai Sarana Peningkatan Life Skill Siswa SD Bernuansa Alam Desa Darsono
Authors: Cahyaningtyas Cindy Dwi , Widayanti Ayu , Zahra Mutiara Shofia , Widayanti Anis , Miranda Yussy , Rusdianto Rusdianto 
Published: October 2023

Darsono Village is a village located in Arjasa District, Jember Regency, East Java. The economic condition in Darsono Village is relatively low and exacerbated by low literacy skills. Darsono Village has several potentials, such as empty land, beautiful village atmosphere and various facilities in the village. Therefore, we carry out a service program that focuses on improving the quality of formal education through the program "Edu Nature Park: Creative Education Vehicle as a Means of Improving the Life Skills of Elementary School Students with Natural Nuances in Darsono Village, Jember Regency". Edu Nature Park is a fun educational program that refers to nature in Darsono Village. The problem in Darsono Village is that there are still cases of school dropouts due to economic factors and underage marriages to the low interest in reading by the community. The majority of children in Darsono Village often use their time by playing. The method of empowering rural communities is carried out in full in the field (offline) using the PRA (Participatory Rural Appraisal) method.
Immediate Outcome of Intrauterine Growth Restricted Infants
Authors: Islam Md Tariqul , Bhuiyan ANM Nurul Haque , Shameem Md , Sumi Shamima Akter , Jahan Roushan , Islam Mohammad Majharul , Rahman Lutfor 
Published: October 2023

Background: Intrauterine growth restriction (IUGR) is one of the major public health issues in developing countries like Bangladesh. IUGR has got significant importance due to its approach towards post neonatal, infant and childhood mortality and morbidity.
Objective: To identify immediate outcome of IUGR infants.
Methods: This case control study was conducted in department of Neonatology at BSMMU, Dhaka from August 2015 to July 2016, where 98 newborns in the NICU during study period were the study population. All the IUGR babies were labeled as case (Group- A), n=49 and the babies of the same gestational age were labeled as control (Group-B), n=49. The outcome was observed by the caution and careful NICU follow up of the baby. After collection, data were entered into a personal computer and were edited, analyzed, plotted in graphs and tables. Data were analyzed by chi square test, Mann Whitney U tests, using the statistical package for social sciences (SPSS) version 20. P values less than 0.05 (95% CI) were considered statistically significant.
Result: During the study in case group, hypoglycemia (p=0.007) & hyperbilirubinemia (P=<0.001) were statistically significant complication. Length of hospital stay was more (P=0.001) in IUGR group which was also significant. Death was more in IUGR than AGA group.
Conclusion: From our result, we can conclud e that Hypoglycemia and hyperbilirubinemia were significant complication of IUGR babies. IUGR babies had longer hospital stay than AGA babies. Death were more in IUGR babies but was not statistically significant.
Sir Salimullah Med Coll J 2023; 31: 9-12
TINGKAT CEMARAN BAKTERI PADA DAGING AYAM BROILER YANG DI JUAL DI PASAR TRADISIONAL KOTA MATARAM
Authors: Oktaviani Tina Dwi , Janah Maratun 
Published: October 2023

Bakteri rentan mengkontaminasi daging ayam, kontaminasi bakteri pada daging ayam umumnya berasal dari ruangan, peralatan, maupun meja tempat pemotongan ayam serta air yang digunakan selama proses pemotongan hingga pengolahan daging ayam. Penelitian ini betujuan untuk mengetahui ada tidaknya bakteri pada daging ayam yang di jual di pasar tradisional kota Mataram dengan pengambilan sampel menggunakan Random sampling dengan jumlah 16 sampel daging ayam broiler dari empat pasar (masing-masing 4 sampel/pasar) yang ada di pasar tradisional kota mataram dan dianalisis secara deskriftif. Hasil penelitian menunjukkan bahwa pada pedagang ayam ditemukan bakteri dengan rentan 9 xx 10 sampai dengan 19.6 x 10 kolini/gram. Kesimpulan berdasarkan sejumlah sampel dalam penelitian ini menunjukkan daging ayam Broilee tidak memenuhi standar SNI karena telah melebihi batas maksimum Cemaran Mikroba (BMCM) Bakteri.
Whole genome analysis of Rhizopus species causing rhino-cerebral mucormycosis during the COVID-19 pandemic
Authors: Michael Joy Sarojini , Venkatesan Manigandan , Ninan Marilyn Mary , Solaimalai Dhanalakshmi , Sumanth Lydia Jennifer , Varghese Lalee , Kurien Regi , Varghese Rinku Polachirakkal , C George Priya Doss 
Published: October 2023

IntroductionMucormycosis is an acute invasive fungal disease (IFD) seen mainly in immunocompromised hosts and in patients with uncontrolled diabetes. The incidence of mucormycosis increased exponentially in India during the SARS-CoV-2 (henceforth COVID-19) pandemic. Since there was a lack of data on molecular epidemiology of Mucorales causing IFD during and after the COVID-19 pandemic, whole genome analysis of the Rhizopus spp. isolated during this period was studied along with the detection of mutations that are associated with antifungal drug resistance.Materials and methodsA total of 50 isolates of Rhizopus spp. were included in this prospective study, which included 28 from patients with active COVID-19 disease, 9 from patients during the recovery phase, and 13 isolates from COVID-19-negative patients. Whole genome sequencing (WGS) was performed for the isolates, and the de novo assembly was done with the Spades assembler. Species identification was done by extracting the ITS gene sequence from each isolate followed by searching Nucleotide BLAST. The phylogenetic trees were made with extracted ITS gene sequences and 12 eukaryotic core marker gene sequences, respectively, to assess the genetic distance between our isolates. Mutations associated with intrinsic drug resistance to fluconazole and voriconazole were analyzed.ResultsAll 50 patients presented to the hospital with acute fungal rhinosinusitis. These patients had a mean HbA1c of 11.2%, and a serum ferritin of 546.8 ng/mL. Twenty-five patients had received steroids. By WGS analysis, 62% of the Rhizopus species were identified as R. delemar. Bayesian analysis of population structure (BAPS) clustering categorized these isolates into five different groups, of which 28 belong to group 3, 9 to group 5, and 8 to group 1. Mutational analysis revealed that in the CYP51A gene, 50% of our isolates had frameshift mutations along with 7 synonymous mutations and 46% had only synonymous mutations, whereas in the CYP51B gene, 68% had only synonymous mutations and 26% did not have any mutations.ConclusionWGS analysis of Mucorales identified during and after the COVID-19 pandemic gives insight into the molecular epidemiology of these isolates in our community and establishes newer mechanisms for intrinsic azole resistance.
Targeted IFNγ induction by a genetically engineered Salmonella typhimurium is the key to the liver metastasis inhibition in a mouse model of pancreatic neuroendocrine tumor
Authors: Hua Zhan , Wu Shan , Zhang Yulian , Wang Xiuhong , Cui Ju , Li Yunxuan , Yang Chengcheng , Zhai Min , Deng Bo , Yu Bin , Huang Jian-Dong , Wang Zai , Zhou Jianjun 
Published: October 2023

BackgroundLiver metastasis is one of the primary causes of death for the patients with pancreatic neuroendocrine tumors (PNETs). However, no curative therapy has been developed so far.MethodsThe anti-tumor efficacy of a genetically engineered tumor-targeting Salmonella typhimurium YB1 was evaluated on a non-functional INR1G9 liver metastasis model. Differential inflammatory factors were screened by Cytometric Bead Array. Antibody depletion assay and liver-targeted AAV2/8 expression vector were used for functional evaluation of the differential inflammatory factors.ResultsWe demonstrated that YB1 showed significant anti-tumor efficacy as a monotherapy. Since YB1 cannot infect INR1G9 cells, its anti-tumor effect was possibly due to the modulation of the tumor immune microenvironment. Two inflammatory factors IFNγ and CCL2 were elevated in the liver after YB1 administration, but only IFNγ was found to be responsible for the anti-tumor effect. Liver-targeted expression of IFNγ caused the activation of macrophages and NK cells, and reproduced the therapeutic effect of YB1 on liver metastasis.ConclusionWe demonstrated that YB1 may exhibit anti-tumor effect mainly based on IFNγ induction. Targeted IFNγ therapy can replace YB1 for treating liver metastasis of PNETs.
A SEER database retrospective cohort of 547 patients with penile non-squamous cell carcinoma: demographics, clinical characteristics, and outcomes
Authors: Ashley Lucas W. , Sutton Kent F. , Ju Andrew , Edwards George , Pasli Melisa , Bhatt Arjun 
Published: October 2023

IntroductionLittle research has investigated the prevalence and distribution of the diverse pathologies of non-squamous cell carcinoma (non-SCC) of the penis. Although rare in clinical practice, these cancers have become a focus of greater importance among patients, clinicians, and researchers, particularly in developing countries. The principal objective of this study was to analyze the major types of penile non-SCC, elucidate common treatment pathways, and highlight outcomes including 5-year survival.Materials/methodsThe Surveillance, Epidemiology, and End Results (SEER) database was queried between 2000 and 2018 to identify a retrospective cohort of patients with penile non-SCC. Demographic information, cancer characteristics, diagnostic methods, treatments administered, and survival were investigated.ResultsA total of 547 cases of penile non-SCC were included in the analysis. The most prevalent non-SCC cancers included epithelial neoplasms, not otherwise specified (NOS) (15.4%), unspecified neoplasms (15.2%), basal cell neoplasms (13.9%), blood vessel tumors (13.0%), nevi and melanomas (11.7%), and ductal and lobular neoplasms (9.9%). Over half (56.7%) of patients elected to undergo surgical intervention. Patients rarely received systemic therapy (3.8%) or radiation (4.0%). Five-year survival was 35.5%. Patients who underwent surgery had greater annual survival for 0–10 years compared to those who did not have surgery. Significant differences in survival were found between patients who had regional, localized, and distant metastases (p &lt; 0.05). A significant difference in survival was found for patients married at diagnosis versus those who were unmarried at diagnosis (p &lt; 0.05). Lower survival rates were observed for patients older than 70 years.DiscussionAlthough less prevalent than SCC, penile non-SCC encompasses a diverse set of neoplasms. Patients in this cohort had a high utilization of surgical management leading to superior outcomes compared to those not receiving surgery. Radiation is an uncommonly pursued treatment pathway. Patient demographics and socioeconomic variables such as marital status may be valuable when investigating cancer outcomes. This updated database analysis can help inform diagnosis, management, and clinical outcomes for this rare group of malignancies.
Dermatological evaluation in dogs with atopic dermatitis treated with full-spectrum high cannabidiol oil: a pre study part 1
Authors: Mariga Carollina , Souza Silva Mateus Ana Lúcia , dos Santos Dullius Ângela Isabel , da Silva Ana Paula , Martins Flores Mariana , Vasconcelos Soares André , Amazonas Erik , Tadeu Lemos Pinto Filho Saulo 
Published: October 2023

IntroductionDermatological consultations represent a great part of the small animal medical clinic routine. Canine atopic dermatitis (CAD) is a common skin disease that affects a significant amount of dogs, making it a relevant consideration in clinical practice. The role of the endocannabinoid system on skin homeostasis has been described and its deregulation contributes to dermatopathies. Its function in specialized skin cells reveals an expressive therapeutic potential. Due to the difficulties and the growing scientific evidence of the therapeutic benefits of cannabis on animals, this work aimed to evaluate the anti-inflammatory effects of cannabis-derived oil in the treatment of CAD.MethodsFourteen canines diagnosed with CAD were divided into two groups: T: full spectrum high cannabidiol (CBD) cannabis oil, 2,5 mg/kg; and C: control group (treated with olive oil alone). The effectiveness was evaluated based on the degree of pruritus, dermatological evaluation (CADESI-4) and histopathological evaluation of the skin including mast cell count.ResultsDespite the theoretical basis, there were no significant results obtained between the compared treatments.DiscussionThus, it can be concluded that although full spectrum high cannabinoids therapy presents a promising approach to immunological diseases, further research is required in order to establish the actual effective cannabinoid ratio within the myriad possible combinations and for multi-target therapy of CAD.