bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSMENT OF COLLAGEN CATABOLISM INTENSITY IN THE DEVELOPMENT OF POSTOPERATIVE DEFECTS IN MANDIBULAR BONE TISSUE
Authors: Hattou V.V. , Boyko I.V. , Gavriliev V.M. , Bukhanchenko O.P. , Lokes K.P. 
Published: December 2023

Tooth extraction is the most common surgery in the world. A significant number of factors influence the processes of remodeling and mineralization of newly formed bone tissue. Various methods contributing to the minimization of postoperative consequences have been proposed. Placenta cryoextract has pronounced antioxidant properties and anti-inflammatory effect. Quercetin is a drug with antioxidant and membrane-stabilizing properties that is able to improve the processes of reparative osteoregeneration.
The aim of this study is to improve the prevention of inflammatory complications and stimulation of mandibular osteogenesis after tooth extraction by local administration of cryopreserved placenta as monotherapy and in combination with quercetin.
Materials and methods. We examined 90 patients who underwent tooth extraction and categorized them into three groups of 30 individuals each: group 1 received local application of cryopreserved placenta in the alveolus of the extracted tooth; group 2 underwent a combination of cryopreserved placenta and intravenous administration of quercetin; group 3 served as the control. To assess the intensity of collagen catabolism, we studied the hydroxyproline content in urine.
Results. On the 10th day after tooth extraction, the content of hydroxyproline in urine was significantly increased in all three groups by 40.6%, 35.5%, and 57.8%, respectively. Compared to the control, the excretion of hydroxyproline was lower by 10.2% in the group 1 and by 11.7% in the group 2. After 20 days, a decrease in the content of hydroxyproline by 7.1% in the group 1 and by 11.2% in the group 2 was observed. On the 30th day, a decrease in hydroxyproline excretion was noted in all groups by 12.5%, 9.7% and 16.5%, and on the 90th - by 13.9%, 13.3% and 16.8%, respectively.
The highest excretion of hydroxyproline was observed on the 10th day of observation in all studied groups, signifying a notable level of collagen breakdown. Notably, the group receiving the standard treatment protocol supplemented with the combined use of cryopreserved placenta and quercetin exhibited the smallest fluctuations. This suggests a positive impact on the processes involved in the replacement of small mandibular bone defects.
THE STATE OF THE HEMOCOAGULATION LINK IN THE HEMOSTASIS SYSTEM OF MICE AFTER PARTIAL LIVER RESECTION UNDER ADMINISTRATION OF PLATELET AUTOMESOCONCENTRATE
Authors: Salyutin R.V. , Yuzvyk K.O. 
Published: December 2023

The purpose of the study is to evaluate the indicators of the hemocoagulation link in the hemostasis system of mice after partial resection of the liver under the platelet automesoconcentrate administration.
Materials and methods. 2/3 of the liver was resected in wild-type mice. The animals were divided into three groups: I - control; II – mice that underwent partial hepatectomy; ІІІ – mice that were injected with automesoconcentrate of platelets in a dose of 1 ml/kg during surgery into the liver remnant.
Results and discussion. The study has shown that during the first day following the liver resection, hemocoagulation processes decrease that was indicated by a reduction in the content of platelets and fibrinogen in the blood and a simultaneous increase in the parameters of thrombin time, prothrombin time, and International Normalized Ratio. In the period from the 4th to the 7th day of the study, an increase in the levels of platelets and fibrinogen and a decrease in the indicators of thrombin time, prothrombin time, and Activated Partial Thromboplastin Timer were revealed, however, the studied indicators did not acquire the values ​​of the control group of animals. Administration of automesoconcentrate is a dose of 1 ml/kg directly into the liver remnant during the hepatectomy procedure helps to normalize the hemocoagulation system on the seventh day after the procedure.
Administration of automesoconcentrate also prevents the development of hypocoagulation, vascular wall defects (vasculitis, reduction in the thickness of the walls of microvessels), deficiency of blood coagulation factors. The high concentration of platelets in the automesoconcentrate enables to effectively avoid the loss of platelets and fibrinogen, coagulation factor V, coagulation factor VIII and other coagulation components. Along with this, the automesoconcentrate helps to restore the functional capacity of the liver after resection of a significant part of it, since hepatectomy damages the liver function of patients.
Conclusions. Administering platelet automesoconcentrate effectively prevents the loss of platelets, fibrinogen, coagulation factor V, coagulation factor VIII, and other crucial coagulation components.
HISTORY OF PRETERM INFANTS WITH HYPOXIC BRAIN DAMAGE
Authors: Soloviova H.O. , Tsvirenko S.M. , Kalyuzhka O.O. , Zhuk L.A. , Sitalo V.S. 
Published: December 2023

Relevance. According to the experts of World Health Organization, diseases linked to perinatal hypoxic brain damage account for 70-80% of cases of childhood disability.
This study aims to explore the historical records of heart rate and respiratory characteristics in preterm infants with hypoxic brain damage.
Subjects and Methods. A prospective cohort study was conducted involving 160 preterm infants categorized into three groups: group I comprised conditionally healthy children, group II included children with hypoxic-ischemic central nervous system lesions, and group III involved children with hypoxic-hemorrhagic central nervous system lesions.
Results. The analysis of heart rate parameters according to the data of daily monitoring of electrocardiogram has revealed a positive dynamic of reduction of heterotopic activity and a significant (p<0.05) improvement in the functional state of the conduction system of the heart in all preterm infants aged 20-30 months after a course of timely rehabilitation therapy of hypoxic brain damage. The presence of periodic breathing with respiratory pauses in preterm patients in the neonatal period was established, and a significantly longer duration of apnea was found in children with hypoxic-hemorrhagic central nervous system damage. There has been found an inverse correlation of moderate strength between gestational age and the amount of apnea during the day. Throughout the observation period, there was a gradual establishment of the sleep profile and its structural characteristics, indicating a physiological consolidation process marked by a regular alternation of stable rhythm phases. However, in newborns with hypoxic brain damage, autonomic dysregulation of heart rhythm persisted in the form of hypersympathicotonia. This suggests a high level of electrical instability of the myocardium, underscoring the necessity for ongoing clinical monitoring.
Web of Science Core Koleksiyonunda Yer Alan Derin Öğrenme Algoritmasının Tıbbi Görüntülemede Kullanımına İlişkin Türkiye'de Yapılan Çalışmaların Bibliyometrik Analizi
Authors: AÇIKGÖZ Güneş 
Published: December 2023

Amaç
Teknolojideki son gelişmeler ve veri setlerindeki artış tıbbi görüntülerde yapay zekanın en temel yaklaşımlarından biri olan derin öğrenme algoritmasının popülaritesini arttırmaktadır. Bu nedenle, yapılan çalışmada derin öğrenme algoritmasının kullanımına ilişkin yayınları araştırmak ve derin öğrenmenin kullanımına dikkat çekmek için bibliyometrik analiz yapılması amaçlanmıştır.
Yöntem
"Deep Learning" OR "DL" AND "Medical Imaging" AND “Radiology” anahtar kelimeleri kullanılarak 2019 ile 2022 yıllarında yayınlanan veriler Web of Science Core Collection (WOSCC) veritabanından elde edildi. WOS veritabanında araştırma alanı (Research areas) “Radiology Nuclear medicine medical imaging” ve ülke (Region/Country) alanı “Turkey” ve doküman tipi (Document type) “article” olanlar çalışmaya dahil edildi.
Bulgular
Yapılan çalışmada araştırılan konu ile ilgili toplam 259 yazardan en az 1 yayını ve 1 atıfı olacak şekilde seçim yapıldığında 211 yazar elde edildi. Yazarlar tarafından en az 1 kez kullanılan 195 anahtar kelime elde edildi. Elde edilen anahtar kelimeler arasında en sık kullanılan anahtar kelimelerden “deep learning” ve “artificial intelligence” olduğu görüldü. Ayrıca yapay zekayla ilgili olan “Transfer learning” ve “Machine learning” anahtar kelimelerinin de diğer anahtar kelimelere göre daha sık kullanıldığı görüldü. Dergiler arasında en çok atıfın 133 atıf ile 2021’de “Medical Image Analysis” dergisinde yayınlanan makaleye yapıldığı görüldü. Ayrıca “Medical image analysis” dergisinin 268 atıf ve 8 doküman ile ilk sırada yer aldığı görüldü. Bu derginin ortalama yayın yılının 2021’de fazla olduğu görüldü.
Sonuç
Derin öğrenme algoritmalarının görüntü segmentasyonu, görsel hesaplama, algılama ve sınıflandırma gibi farklı görevlerinin yanı sıra radyasyon dozunun azaltılmasına yardımcı olma gibi avantajları bulunmaktadır. Dolayısıyla derin öğrenme algoritmasının kullanımının tıbbi görüntüleme alanında gittikçe artması kaçınılmazdır. Yapılan çalışma özellikle derin öğrenmenin tıbbi görüntülemede kullanılması ile ilgili verilerin bibliyometrik analizinin yapılmasının farkındalık oluşturacağını ve yararlı olacağını umuyoruz.
Libraries of Higher Education Institutions in the Prevalence of Open Science Practices
Authors: Kasian Vladyslav , Kushnarov Valerii 
Published: December 2023

The aim of the article is to determine the state and directions for improving the implementation effectiveness of the open science concept in libraries of higher education institutions of Ukraine.
Research methods. To achieve the set goal and solve the tasks, content analysis, systematic approach, methods of analysis and synthesis, generalization and systematization are used.
Scientific novelty. On the basis of the formed sample of 12 libraries of Ukrainian higher education institutions (HEIs), the thematic range of electronic resources and services of institutional repositories is identified, as well as the methodical and regulatory support for their functioning is characterized. The article highlights peculiarities of implementing the basic principles of open science by libraries of Ukrainian HEIs, additionally, reveals the reserves for developing an open information space for scientists and education seekers.
Main conclusions. Based on the analysis of Ukrainian and foreign researchers’ scientific works, the contribution of scholars to the formation of conceptual foundations of open science as a communication phenomenon, which is of key importance for the development of the digital society and knowledge society in total, is established. A number of priority tasks that need to be solved are formulated: improving the means of technological support for institutional repositories; providing libraries of HEIs with open access to subscribed resources and abstract bibliographic databases, as well as collections of digitized publications included in the State Register of National Cultural Heritage of Ukraine; providing educational materials in open access (disciplines programs, lectures notes, meetings protocols, didactic materials, etc.); elaborating and implementing a number of information, library and educational methodologies of scientific interaction with different categories of users. The significance of the resource potential of modern practices in HEIs libraries in prevalencing the achievements of open science is substantiated and summarized; the current state of implementing the open science concept in Ukrainian HEIs is determined. Prospects for further research include testing different aspects of the open access implementation; development of open science tools and services by HEIs libraries.
Improving the Professional Competencies of Students of the Specialty 029 IBAS (ILAS) in the Process of Practice Performing
Authors: Bachynska Nadiia 
Published: December 2023

The aim of the article is to determine step-by-step improving the professional competences of the first education level students in specialty 029 “Information, Library and Archival Studies” in conditions of the practice process, and in accordance with the standard, educational and professional programs elaborated by the Department of Information Technologies at Kyiv National University of Culture and Arts (KNUKiM/KNUCA).
Research methods are based on both general scientific methods and special ones. The use of analysis and synthesis makes it possible to analyze the theoretical research foundation. Systemic and structural-functional methods make it possible to comprehensively study the peculiarities of the practice organization at different educational levels. Argumentation of conclusions and scientific ideas is carried out using the method of generalization and content analysis.
The scientific novelty consists in substantiating the step-by-step competences formation in practice conditions by students of the first education level, in accordance with the Standard of Higher Education of Ukraine: the first level (a Bachelor’s degree), a field of study 02 Culture and Art, specialty 029 “Information, Library and Archival Studies”, as well as educational and professional programs developed at the Department of Information Technologies, namely, “Manager of Library and Information Systems and Technologies”, “Documentation Science Specialist, Manager of State and Local Authorities”.
Main conclusions. The first Bachelor’s degree of higher education requires students to master an educational and professional program. A mandatory component of this program is introductory, educational, productional and pre-diploma practice. The process of practice performing is aimed at improving, deepening and developing professional competencies that are formed during the assimilation of theoretical material and practical classes.
The organization of practice in appropriate bases, particularly, in libraries, archives, information and analytical institutions, and other documentary and communication establishments has a number of advantages, contributes to the development of integral, general and professional competences.
The effectiveness of the students’ acquisition of professional competencies depends on a variety of factors, which include these ones: the quality of practice, the training program and the tutors’ support, the students’ activity, the relevance of practice to educational goals, feedback and self-evaluation, which, in turn, help future specialists to prepare for a successful career, expand their opportunities, and increase confidence in their own abilities.
Impact of the COVID-19 pandemic on mode of delivery
Authors: GÜNDOĞDU Elif , ÜNLÜGEDİK SAYIN Elif , KAHRAMAN KAYA Medine 
Published: December 2023

Aims: The first case of COVID-19 was reported on March 11th, 2020, in Turkey, and the measures taken by the state to prevent the spread of the virus were put on hold by March 2022. The purpose of this study is to present information with special focus on mode of delivery among pregnant women during COVID-19 pandemic. We aimed to assess the effect of pandemic on the rates of normal vaginal delivery and C-section.
Methods: This is a restrospective cohort study including all pregnant women at more than 20 weeks of gestation admitted to labour and delivery unit in an academic tertiary care hospital. Records of patients two years before the pandemic and two years of the pandemic were extracted. The number of pregnants admitted to the labour and delivery, the mode of delivery, selected method of anesthesia, total expenses of the patients, the length of hospital stay, indications for cesarian section were compared between the two periods.
Results: A total of 9048 patients were identified, of which 4745 were before the pandemic and 4303 during the pandemic. The most striking finding was the decrease in C-section rates during pandemic which was mostly due to decrease in number of primary C-sections. The length of hospital stay was shorter during pandemic as well. The mean age, route of anesthetics, surgery length did not differ between the two groups.
Conclusion: The available evidence on COVID-19’s potential impact on C-section rates is conflicting. Some suggest that there might be evidence indicating a possible link between COVID-19 and increased rates of C-section. However, this study showed that when all the deliveries are included pandemic caused a significant decrease in the rates of primary C-section which might be due to decreased interventions of the healthcare professionals.
Relation between impaired coronary microvascular circulation and plasma atherogenic index in patients with ankylosing spondylitis
Authors: ÖZKAN Eyüp , YILMAZ Yücel , ÇELİK Fatma Betül , KELEŞOĞLU Şaban , DOĞAN Yasemin , DEMİRCİ Erkan , KASAPOĞLU Esen , BİLGİLİ Ümmühan Zeynep , CALISKAN Mustafa 
Published: December 2023

Aim: The coronary flow reserve (CFR) is a sign of endothelial dysfunction and early-stage coronary artery disease (CAD). Plasma atherogenic index (PAI) is related to subclinical CAD and may be used as a predictor of cardiovascular mortality. Our aim is to determine CFR and PAI in patients with AS and to investigate whether PAI can be used in the detection of early stage CAD.
Methods: The study population comprised 48 patients, who were diagnosed with AS based on modified New York criteria and 35 healthy volunteers. PAI values were calculated with the formula log 10 triglyceride (TG) / high-density lipoprotein (HDL).
Results: No difference was detected between the two groups for the demographic variables, including age, sex and BMI. The comparison of the groups for PAI and CFR demonstrated that PAI levels were observed to be significantly higher and CFR levels were observed to be significantly lower in the AS patients (p=0.01, p
The investigation of serum nectin-4 levels in patients with early onset preeclampsia
Authors: ACAR Züat , OBUT Mehmet , GEDİK ÖZKÖSE Zeynep , SUCU Sadun , SEZER Salim , BUCAK Mevlüt , DAĞ İsmail , ERCİYESTEPE Sezgi Güllü , ÖZDEMİR İsmail 
Published: December 2023

Aims: We aimed to investigate the level and predictive value of soluble nectin-4 in early onset preeclampsia (EOPE).
Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study. The groups were matched for gestational age and gravidity. Serum nectin-4 levels were compared between groups. The ROC curve was drawn to show the predictive value of nectin-4 for EOPE. Patients were followed up until the end of labor, and perinatal outcomes were recorded.
Results: The demographic characteristics of the two groups were similar. Serum nectin-4 level was significantly increased in EOPE cases compared to controls (226.46±119.6 ng/ml vs. 156.54±44.8 ng/ml, p=0.001). The ROC showed that at > 160.938, the sensitivity and specificity were 67.44% and 82.93%, respectively [AUC:0.822, (CI:0.724 - 0.897), and (p< 0.001)]. Significant inverse correlations were found between nectin-4 levels and poor obstetric outcomes.
Conclusion: Maternal serum nectin-4 levels were significantly higher in patients with EOPE compared with controls. Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.
Determination of malnutrition status in hospitalized Turkish Republic citizen and refugee children with different diagnoses
Authors: DULKADİR Ramazan 
Published: December 2023

Aims: Malnutrition is defined as changes in the normal body structure due to inadequate nutrition. This study aimed to determine the malnutrition status of Turkish children and refugee children.
Methods: A total of 5528 patients between the ages of 1 month and 18 years who were admitted and followed up in our pediatric health and diseases department between January 2017 and January 2020 were evaluated. The Gomez classification was used to assess malnutrition status. Demographic data, admission diagnoses, and the degree of malnutrition were retrospectively recorded by examining medical records. Both groups were compared in terms of these parameters.
Results: In our study, 5528 patients between the ages between 1 month and 18 years were evaluated. The median age was 4.1 years (min:1 month, max:17 years), with 2274 (41.1%) being female and 3254 (58.9%) being male. Among the cases, 4994 (90.5%) were Turkish, 160 (2.8%) were Afghan, 198 (3.5%) were Iraqi, and 176 (3.2%) were Syrian. According to the Gomez classification, 4379 patients (79.2%) were normal and 1148 patients (20.8%) were malnourished. Among the malnourished patients, 995 (86.7%) were mildly malnourished, 117 (10.2%) were moderately malnourished, and 36 (3.1%) were severely malnourished. 44% (n=16) of severely malnourished patients were under the age of two. The malnutrition rates were 19.7%, 22.5 %, 30.8 %, and 36.4% in Turkish, Afghan, Iraqi, and Syrian patients, respectively. There was a significant difference between Syrian and Turkish patients with mild and moderate malnutrition (P
Anoplasty and information pollution in health on YouTube
Authors: POYRAZOĞLU Ömer Bilgehan 
Published: December 2023

Aims: One of the most fundamental human rights is the right to information. The aim of our study is to investigate the accuracy, reliability and comprehensibility of the videos made on YouTube about anal stenosis. However, users often do not question this information's accuracy, adequacy, and efficiency. Anal stenosis is a disease that we frequently encounter for iatrogenic reasons, especially after post hemorrhoidectomy. When many publications are reviewed, anal stenosis can be seen in 1.2%-10% of patients undergoing hemorrhoidectomy.
Methods: Our study primarily and mainly YouTube videos about anoplasty published in English were preferred. However, when sufficient videos could not be reached scientifically, other videos were translated into English and included in the study. As of March 1, 2021, "anoplasty" was typed into the youtube search engine, and Thirty-eight videos of the most relevant videos on this subject were examined.JAMA,DISCERN,GQS was used for assessment in this study.
Result: The averages of the JAMA, DISCERN, and GQS fitness parameters used in the study were found to be 2.55 (1-4), 36.58 (18-59), and 2.84 (1-5), respectively. Of the 38 videos evaluated, 7 got 5 points according to GQS, and 8 got 4 points according to JAMA. According to DISCERN, none of them got full points. It could get a maximum of 59 points. It was also a single video. A statistically significant relationship was found among these parameters (GQS, JAMA, DISCERN) (p .05 )
Conclusion: We believe that this study will contribute to those who will share about health on YouTube within the framework of more accurate and scientific rules; therefore, it will raise awareness. Primarily this is necessary and essential for videos made in the name of health.