bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing the Workforce of the Digital Future: mHealth Competency and Fidelity Measurement in Community-Based Care
Authors: Kopelovich Sarah L. , Buck Benjamin E. , Tauscher Justin , Lyon Aaron R. , Ben-Zeev Dror 
Published: January 2024

AbstractIntegrating mobile health (mHealth) interventions into settings that serve diverse patient populations requires that prerequisite professional competencies are delineated and that standards for clinical quality assurance can be pragmatically assessed. Heretofore, proposed mHealth competencies have been broad and have lacked a framework to support specific applications. We outline the meta-competencies identified in the literature relevant to mHealth interventions and demonstrate how these meta-competencies can be integrated with population- and intervention-related competencies to help guide a pragmatic approach to competency assessment. We present a use case based on FOCUS—an evidence-based mHealth intervention designed for individuals with serious mental illness and currently being implemented in geographically and demographically diverse community behavioral health settings. Subsequent to identifying the cross-cutting competencies relevant to the target population (outpatients experiencing psychotic symptoms), substratal intervention (Cognitive Behavioral Therapy for psychosis), and treatment modality (mHealth), we detail the development process of an mHealth fidelity monitoring system (mHealth-FMS). We adhered to a published sequential 5-step process to design a fidelity monitoring system that aligns with our integrated mHealth competency framework and that was guided by best practices prescribed by the Treatment Fidelity Workgroup of the National Institutes of Health Behavior Change Consortium. The mHealth-FMS is intended to enhance both clinical and implementation outcomes by grounding the mHealth interventionist and the system of care in which they operate in the core functions, tasks, knowledge, and competencies associated with system-integrated mHealth delivery. Future research will explore acceptability and feasibility of the mHealth-FMS.
Social networking usage and mental health problems in the Kurdistan region of Iraq during the COVID-19 outbreak and lockdown
Authors: Hama amin Dyari S. , Mohammad Parzheen J. 
Published: January 2024

AbstractThe COVID-19 outbreak, as an international health emergency, led to uncertainty. Pandemics can be stressful and anxiety-producing for community individuals. Moreover, due to lockdown measures implemented to slow down the spread of the disease, an increase in the usage of social media was reported. Therefore, this study aims to find the prevalence of mental health problems and the level of social media usage during the outbreak of COVID-19 in the Kurdistan region, Iraq. Furthermore, the relationship between mental health problems (i.e., depression, anxiety, and stress) and social media usage is explored. The study was cross-sectional; the data was collected through a snowball sampling method in which 355 participants completed an online questionnaire. Social networking usage questionnaire, Hopkins Symptom Checklist-15 (HSCL-25), and Perceived Stress Scale (PSS) were used as measurement tools. The results showed that the level of social networking usage was moderate. As for mental health problems, 76.5% of the respondents showed moderate to high stress levels, 56.4% reported experiencing depression, and 37.4% reported experiencing anxiety. Significant gender differences were found in depression, anxiety, and stress, with females scoring higher in all categories. In the mental health problem domains, only depression scores positively correlated with social media usage. The findings also showed social networking usage is associated with higher depression and anxiety; however, the effect sizes were small. Therefore, more research into this matter is necessary in the cultural context of the Kurdistan region to reach conclusive results.
Implementation of direct battery driven discharge in triggerless operation of vacuum arc thrusters
Authors: Saletes James , Saddul Kash , Wittig Alexander , Kim Minkwan 
Published: January 2024

AbstractThe increasing demand for CubeSat missions with limited budgets and constrained timelines necessitates the development of innovative propulsion systems. This paper focuses on vacuum arc thrusters (VATs) and investigates the implementation of battery-driven discharge for triggerless firing. VATs offer a promising alternative for CubeSat propulsion, generating thrust through the pulsed ejection of plasma in a cathode arc discharge. The study explores the feasibility of direct battery-driven discharge in VATs and demonstrates stable and variable-duration pulses. Experimental testing using high C-rating lithium-ion (Li-ion) batteries showcase the advantages and operational benefits of this approach. The results highlight the potential for variable energy pulses, precise control of thrust impulse bit, and improved performance compared to capacitor-driven systems. Future research directions include optimising pulse duration for enhanced lifetime, plume analysis, and erosion rate investigations. The implementation of VATs with battery-driven discharge presents a promising solution to enhance the performance and reliability of CubeSat propulsion systems while ensuring compliance with space sustainability guidelines.
What is coastal subsidence?
Authors: Törnqvist Torbjörn E. , Blum Michael D. 
Published: January 2024

Abstract
Major technological advances have made measurements of coastal subsidence more sophisticated, but these advances have not always been matched by a thorough examination of what is actually being measured. Here we draw attention to the widespread confusion about key concepts in the coastal subsidence literature, much of which revolves around the interplay between sediment accretion, vertical land motion and surface-elevation change. We attempt to reconcile this by drawing on well-established concepts from the tectonics community. A consensus on these issues by means of a common language can help bridge the gap between disparate disciplines (ranging from geophysics to ecology) that are critical in the quest for meaningful projections of future relative sea-level rise.
Cogroupoid structures on the circle and the Hodge degeneration
Authors: Moulinos Tasos 
Published: January 2024

AbstractWe exhibit the Hodge degeneration from nonabelian Hodge theory as a$2$-fold delooping of the filtered loop space$E_2$-groupoid in formal moduli problems. This is an iterated groupoid object which in degree$1$recovers the filtered circle$S^1_{fil}$of [MRT22]. This exploits a hitherto unstudied additional piece of structure on the topological circle, that of an$E_2$-cogroupoid object in the$\infty $-category of spaces. We relate this cogroupoid structure with the more commonly studied ‘pinch map’ on$S^1$, as well as the Todd class of the Lie algebroid$\mathbb {T}_{X}$; this is an invariant of a smooth and proper schemeXthat arises, for example, in the Grothendieck-Riemann-Roch theorem. In particular, we relate the existence of nontrivial Todd classes for schemes to the failure of the pinch map to be formal in the sense of rational homotopy theory. Finally, we record some consequences of this bit of structure at the level of Hochschild cohomology.
The trilobite assemblage of the Declivolithus Fauna (lower Katian, Ordovician) of Morocco: a review with new data
Authors: Pereira Sofia , Rábano Isabel , Gutiérrez-Marco Juan Carlos 
Published: January 2024

AbstractIntense commercial exploitation of fossils in the famous El Qaid Errami area in the last 20 years has led to the discovery of the interesting Declivolithus Fauna in the Moroccan Anti-Atlas. This unusually large trinucleid trilobite, described originally from the Czech Republic, is the most conspicuous element of an assemblage mainly occurring in the Bofloss locality, a local biofacies development of pelagic mudstones and sandstones cropping out in a structurally isolated place in the Tizi n'Ounfite area. Here we revise this Declivolithus Fauna trilobite assemblage from Morocco, increasing the known trilobite diversity from four to 11 species: Ulugtella? biformis n. sp., Selenopeltis cf. S. vultuosa, Phacopidina quadrata, Eudolatites cf. E. bondoni, Prionocheilus cf. P. verneuili, Nobiliasaphus cf. N. kumatox, Cyclopyge cf. C. rediviva, Symphysops stevaninae, Heterocyclopyge sp., Dionide sp., and Declivolithus alfredi. The new data and the very good preservation of specimens in sandstones, clarify the specific identity of previously reported taxa. Although the stratigraphical correlation of the fossiliferous levels remains problematic, it probably corresponds to the upper part of the Lower Ktaoua Formation or to the lower half of the Upper Tiouririne Formation. Most taxa support previous assignment of the Moroccan assemblage to the late Berounian (ca. early Katian, Ka2), although a middle Berounian (ca. Sa2–Ka1) age cannot be excluded. Most of the identified species are known from the Czech Republic (eight out of 11), showing that the strong faunal link between Morocco and the Czech Republic still existed during the Late Ordovician, being stronger than the link with the coeval Ibero-Armorican domain faunas.UUID: http://zoobank.org/3e6e55c7-168d-4008-98ba-38a795581ca3
The development of aGender, Inclusion and Diversity Frameworkfor inclusive Nature-based Solutions in cities
Authors: Delbaere Ben , Pereira Barboza Evelise , Van Rafelghem Evelien , Potter Kalyn , McCabe Eilish , McBeth Áine , Utkarsh Shreya , Rudd Kassia , Fernandez de Osso Fuentes Maria J. , Duarte Adriana , Gäckle Julia , Keune Hans 
Published: January 2024

AbstractEvidence consistently shows that the benefits Nature-based Solutions generate are determined by several individual characteristics such as gender, age, sexuality, ethnicity and disability. As a result, Nature-based Solutions can perpetuate existing inequalities and even create new inequalities partly because diverse minority and marginalized people are underrepresented in the process of designing and implementing Nature-based Solutions. Therefore, some Nature-based Solutions scholars have highlighted the necessity to actively involve diverse minority and marginalized groups into the co-creation processes of Nature-based Solutions and to investigate who benefits from the Nature-based Solution and why. Within the GoGreenRoutes H2020 project a transdisciplinary gender, inclusion and diversity panel was established in order to map existing challenges within the consortium. Concordantly, relevant scientific resources and policy documents were identified. Both were blended during consensus meetings in order to develop a common understanding leading to a theoretical gender, inclusion and diversity framework. This framework consists of five domains: (1) gender equality; (2) LGBTQI + rights; (3) social, cultural and ethnic background; (4) people with disabilities; (5) integration of refugees and immigrants; and (6) intergenerational perspectives. Further, the framework was operationalized through the development of a checklist for researchers and practitioners.
Context, Contact, and Misinformation about Socially Marginalized Groups in the United States
Authors: Abrajano Marisa , Lajevardi Nazita , Uribe Laura 
Published: January 2024

AbstractHow does context influence individuals’ misinformation about socially marginalized groups? Scholarship has long found that one’s geographical and social environment are important determinants for one’s political attitudes. But how these contexts shape individuals’ levels of misinformation about stigmatized groups remains an open and pressing question, especially given the swift rise of misinformation in recent years. Using three original surveys, we find that individuals who report more contact with a diverse group of individuals were significantly less likely to be misinformed. These findings are particularly pronounced among white Americans. Moreover, contrary to the popular belief that where one lives is a strong determinant of racial attitudes, we also find that partisan and racial context did not meaningfully shape misinformation. These findings shed light on the factors that helps us to understand the misinformation that exists about this sizable share of U.S. society.
Reproductive populations of the Critically Endangered bat Phyllonycteris aphylla at two new locations in Jamaica
Authors: Oelbaum Phillip J. , Hall Ronald P. , Whyte Damion L. , Stewart Ronald S. , Pauel Jan , Kouwenberg Silvia , Dumont Elizabeth R. , Welch Kenneth C. 
Published: January 2024

AbstractThe Jamaican flower bat Phyllonycteris aphylla is categorized as Critically Endangered on the IUCN Red List. It is endemic to Jamaica and formerly known only from Stony Hill Cave, where there are an estimated c. 500 individuals. Previously declared extinct twice, its rediscovery in 2010 at Stony Hill Cave marked new hope for the conservation of this important species. Although little is known about its ecology, the species is presumed to be a cave-obligate rooster and to rely exclusively on so-called hot caves, which are defined by high ambient temperatures and low air quality. In March–April 2023, we surveyed bats at seven caves throughout Jamaica. At two of these, Green Grotto Caves, St. Ann, and Rock Spring Caverns, St. Mary, we captured both male and pregnant female P. aphylla. At Green Grotto Caves, we captured 24 P. aphylla, and 66 at Rock Spring Caverns. We believe Rock Spring Caverns to be one of the largest known roosts of P. aphylla. Neither of these sites are hot caves as both are moderated by flowing water, although warmer chambers may be more important to this bat than to other species. Further monitoring of these populations and continued exploration of other potential roosts are vital for the protection of this species.
Ethical Shortcomings of QALY: Discrimination Against Minorities in Public Health
Authors: Andrade Gabriel 
Published: January 2024

Abstract
Despite progress, discrimination in public health remains a problem. A significant aspect of this problem relates to how medical resources are allocated. The paradigm of quality-adjusted-life-year (QALY) dictates that medical resources should be allocated on the basis of units measured as length of life and quality of life that are expected after the implementation of a treatment. In this article, I discuss some of the ethical shortcomings of QALY, by focusing on some of its flawed moral aspects, as well as the way it relates to discrimination on the basis of age, race, and disability status. I argue that while this approach seeks to maximize efficiency, it does not place sufficient value on the preservation of life itself. Even more concerning is the fact that the use of QALY disproportionately harms minorities. While QALY is a well-intentioned approach to the allocation of scarce healthcare resources, new alternatives must be sought.
The oxygen uptake efficiency slope in adults with CHD: group validity
Authors: Redfern J. M. , Hawkes S. , Bryan A. , Cullington D. , Ashrafi R. 
Published: January 2024

AbstractThe maximal oxygen uptake (V02 max) is a well-validated measure of cardiorespiratory function that is calculated during a maximal cardiopulmonary exercise test. V02 max enables physicians to objectively assess cardiopulmonary function to aid in decision-making for patients with CHD. A significant proportion of these patients however are unable to achieve a maximal exercise test, and as such, there is a need for reliable submaximal predictors of cardiorespiratory reserve.The oxygen uptake efficiency slope represents a measure of how effectively oxygen is extracted from the lungs and taken into the body and can be calculated from a submaximal exercise test. Its reliability as a predictor of cardiorespiratory reserve has been validated in various patient populations, but there is limited evidence for its validity in adult patients with CHD.Retrospective analysis of cardiopulmonary exercise test data in 238 consecutive patients with CHD who completed a maximal cardiopulmonary exercise test at our tertiary cardiology centre demonstrated a strong correlation between peak V02 and the oxygen uptake efficiency slope (0.936). A strong correlation with peak V02 was also demonstrated when oxygen uptake efficiency slope was calculated at ventilatory anaerobic threshold (OUESVAT), 75% (OUES75), and 90% (OUES90) of the test (0.833, 0.905, 0.927 respectively).In adult patients with CHD who are unable to complete a maximal cardiopulmonary exercise test, the oxygen uptake efficiency slope is a reliable indicator of cardiopulmonary fitness which correlates strongly with peak V02 at or beyond the ventilatory anaerobic threshold. Further research is required to validate the findings in patients with less common anatomies and to assess the relationship between the oxygen uptake efficiency slope and mortality.
Preconditioned Stratospheric Modulation on the Occurrence of Stratospheric Final Warmings
Authors: Yang Pengkun , Bao Ming , Ren Xuejuan 
Published: January 2024

AbstractStratospheric Final Warmings (SFWs) are considered to have a distinct impact on the surface weather and stratospheric ozone. Most SFWs are predominantly wave‐driven, while previous studies generally focused on the effects of tropospheric anomalous wave forcing on stratospheric wave amplification. This study demonstrates the crucial role of preconditioned stratospheric modulation on the occurrence of wave‐driven SFWs in the Northern Hemisphere, using ERA5 reanalysis. In most cases, the preconditioned stratospheric state is the key factor in determining the occurrence of both early and late SFWs. The tropospheric anomalous wave forcing cannot independently trigger most SFWs without stratospheric modulation. The proportion of anomalous stratospheric signals followed by SFWs is much higher than that of anomalous tropospheric forcing, even if the proportions of SFWs preceded by anomalous stratospheric signals and tropospheric wave forcing are similar. Additionally, about 25% of SFWs are only preceded by stratospheric modulation without anomalously strong tropospheric wave amplification.
Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins
Authors: Li Lin , Ran Jie 
Published: January 2024

AbstractCilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling. Their proper assembly and function rely on the bidirectional intraflagellar transport (IFT) system, which involves motor proteins, including antegrade kinesins and retrograde dynein. Although the role of IFT-mediated transport in cilia has been extensively studied, recent research has highlighted the contribution of IFT-independent kinesins in ciliary processes. The coordinated activities and interplay between IFT kinesins and IFT-independent kinesins are crucial for maintaining ciliary homeostasis. In this comprehensive review, we aim to delve into the specific contributions and mechanisms of action of the IFT-independent kinesins in cilia. By shedding light on their involvement, we hope to gain a more holistic perspective on ciliogenesis and ciliopathies.
Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth
Authors: Zuo Yong , Bai Jiawei , Bai Huiyuan , Tian Siyu , Sun Hongtao , Shi Zhenhua , Yu Peng , Gao Guofen , Li Yuan , Chang Yan-Zhong 
Published: January 2024

AbstractTransmembrane serine protease 6 (Tmprss6) has been correlated with the occurrence and progression of tumors, but any specific molecular mechanism linking the enzyme to oncogenesis has remained elusive thus far. In the present study, we found that Tmprss6 markedly inhibited mouse neuroblastoma N2a (neuro-2a) cell proliferation and tumor growth in nude mice. Tmprss6 inhibits Smad1/5/8 phosphorylation by cleaving the bone morphogenetic protein (BMP) co-receptor, hemojuvelin (HJV). Ordinarily, phosphorylated Smad1/5/8 binds to Smad4 for nuclear translocation, which stimulates the expression of hepcidin, ultimately decreasing the export of iron through ferroportin 1 (FPN1). The decrease in cellular iron levels in neuro-2a cells with elevated Tmprss6 expression limited the availability of the metal forribo nucleotide reductase activity, thereby arresting the cell cycle prior to S phase. Interestingly, Smad4 promoted nuclear translocation of activating transcription factor 3 (ATF3) to activate the p38 mitogen-activated protein kinases signaling pathway by binding to ATF3, inducing apoptosis of neuro-2a cells and inhibiting tumor growth. Disruption of ATF3 expression significantly decreased apoptosis in Tmprss6 overexpressed neuro-2a cells. Our study describes a mechanism whereby Tmprss6 regulates the cell cycle and apoptosis. Thus, we propose Tmprss6 as a candidate target for inhibiting neuronal tumor growth.
USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer
Authors: Li Mingxing , Yu Jingtian , Ju Lingao , Wang Yejinpeng , Jin Wan , Zhang Renjie , Xiang Wan , Ji Meng , Du Wenzhi , Wang Gang , Qian Kaiyu , Zhang Yi , Xiao Yu , Wang Xinghuan 
Published: January 2024

AbstractA hallmark of tumor cells, including bladder cancer (BLCA) cells, is metabolic reprogramming toward aerobic glycolysis (Warburg effect). The classical oncogene MYC, which is crucial in regulating glycolysis, is amplified and activated in BLCA. However, direct targeting of the c-Myc oncoprotein, which regulates glycolytic metabolism, presents great challenges and necessitates the discovery of a more clarified regulatory mechanism to develop selective targeted therapy. In this study, a siRNA library targeting deubiquitinases identified a candidate enzyme named USP43, which may regulate glycolytic metabolism and c-Myc transcriptional activity. Further investigation using functional assays and molecular studies revealed a USP43/c-Myc positive feedback loop that contributes to the progression of BLCA. Moreover, USP43 stabilizes c-Myc by deubiquitinating c-Myc at K148 and K289 primarily through deubiquitinase activity. Additionally, upregulation of USP43 protein in BLCA increased the chance of interaction with c-Myc and interfered with FBXW7 access and degradation of c-Myc. These findings suggest that USP43 is a potential therapeutic target for indirectly targeting glycolytic metabolism and the c-Myc oncoprotein consequently enhancing the efficacy of bladder cancer treatment.