bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assignment of individual structures from intermetalloid nickel gallium cluster ensembles
Authors: Muhr Maximilian , Stephan Johannes , Staiger Lena , Hemmer Karina , Schütz Max , Heiß Patricia , Jandl Christian , Cokoja Mirza , Kratky Tim , Günther Sebastian , Huber Dominik , Kahlal Samia , Saillard Jean-Yves , Cador Olivier , Da Silva Augusto C. H. , Da Silva Juarez L. F. , Mink Janos , Gemel Christian , Fischer Roland A. 
Published: February 2024

AbstractPoorly selective mixed-metal cluster synthesis and separation yield reaction solutions of inseparable intermetalloid cluster mixtures, which are often discarded. High-resolution mass spectrometry, however, can provide precise compositional data of such product mixtures. Structure assignments can be achieved by advanced computational screening and consideration of the complete structural space. Here, we experimentally verify structure and composition of a whole cluster ensemble by combining a set of spectroscopic techniques. Our study case are the very similar nickel/gallium clusters of M12, M13 and M14 core composition Ni6+xGa6+y (x + y ≤ 2). The rationalization of structure, bonding and reactivity is built upon the organometallic superatom cluster [Ni6Ga6](Cp*)6 = [Ga6](NiCp*)6 (1; Cp* = C5Me5). The structural conclusions are validated by reactivity tests using carbon monoxide, which selectively binds to Ni sites, whereas (triisopropylsilyl)acetylene selectively binds to Ga sites.
Protein prognostic biomarkers in stage II colorectal cancer: implications for post-operative management
Authors: Alnakli Aziz A. A. , Mohamedali Abidali , Heng Benjamin , Chan Charles , Shin Joo-Shik , Solomon Michael , Chapuis Pierre , Guillemin Gilles J. , Baker Mark S. , Ahn Seong Beom 
Published: February 2024

AbstractColorectal cancer (CRC) poses a significant threat to many human lives worldwide and survival following resection is predominantly stage dependent. For early-stage cancer, patients are not routinely advised to undergo additional post-operative adjuvant chemotherapy. Acceptable clinical management guidelines are well established for patients in pTNM stages I, III and IV. However, recommendations for managing CRC stage II patients remain controversial and many studies have been conducted to segregate stage II patients into low- and high-risk of recurrence using genomic, transcriptomic and proteomic molecular markers. As proteins provide valuable insights into cellular functions and disease state and have a relatively easy translation to the clinic, this review aims to discuss potential prognostic protein biomarkers proposed for predicting tumour relapse in early-stage II CRC. It is suggested that a panel of markers may be more effective than a single marker and further evaluation is required to translate these into clinical practice.
XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis
Authors: Hong Renjie , Tan Yanjie , Tian Xiaoyu , Huang Zhenzhou , Wang Jiaying , Ni Hua , Yang Jia , Bu Weiwen , Yang Song , Li Te , Yu Fan , Zhong Weilong , Sun Tao , Wang Xiaohong , Li Dengwen , Liu Min , Yang Yunfan , Zhou Jun 
Published: February 2024

AbstractActivation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that primary cilia are present on quiescent HSCs but exhibit a significant loss upon HSC activation which correlates with decreased levels of the ciliary protein intraflagellar transport 88 (IFT88). Ift88-knockout mice are more susceptible to chronic carbon tetrachloride-induced liver fibrosis. Mechanistic studies show that the X-linked inhibitor of apoptosis (XIAP) functions as an E3 ubiquitin ligase for IFT88. Transforming growth factor-β (TGF-β), a profibrotic factor, enhances XIAP-mediated ubiquitination of IFT88, promoting its proteasomal degradation. Blocking XIAP-mediated IFT88 degradation ablates TGF-β-induced HSC activation and liver fibrosis. These findings reveal a previously unrecognized role for ciliary homeostasis in regulating HSC activation and identify the XIAP–IFT88 axis as a potential therapeutic target for liver fibrosis.
Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations
Authors: Liu Yuchun , Chen Siqi , Zhang Enhao , Xu Yinbin , Deng Xinpeng , Hu Ziliang , Nie Sheng , Lin Yinglu , Huang Yi 
Published: February 2024

Abstract
DNA methylation is widely recognized to play a role in intracranial aneurysm (IA) pathogenesis. We investigated the levels of methylation of vestigial-like 3 (VGLL3) in IA and explored its potential as a prognostic indicator. A total of 48 patients with IA and 48 healthy controls were included in the present study. Methylation levels of CpG sites were assessed using bisulfite pyrosequencing, and levels of VGLL3, TEAD, and YAP in the blood were measured by real-time quantitative polymerase chain reaction testing. VGLL3 methylation was significantly higher in controls than in IA patients (P=0.001), and this phenomenon was more pronounced in females (P&lt;0.001). Compared with the control group, the expression levels of VGLL3 and TEAD in the blood of IA patients were significantly increased, while YAP was significantly decreased. VGLL3 methylation was positively correlated with HDL (P=0.003) and female Lpa concentration (r = 0.426, P=0.03), and was also negatively correlated with age (P=0.003), APOE (P=0.005), and VGLL3 mRNA expression (P&lt;0.001). Methylation and mRNA expression of VGLL3 may serve as indicators of IA risk in females (AUC = 0.810 and 0.809). VGLL3 methylation may participate in the pathogenesis of IA by regulating the expression of the VGLL3/TEAD/YAP pathway, and its gene methylation and expression levels have IA risk prediction value.
Impact of different approaches to computing rotating stellar models
Authors: Nandal Devesh , Meynet Georges , Ekström Sylvia , Moyano Facundo D. , Eggenberger Patrick , Choplin Arthur , Georgy Cyril , Farrell Eoin , Maeder André 
Published: February 2024

Context. The physics of stellar rotation plays a crucial role in the evolution of stars, in their final fates, and for the properties of compact remnants.
Aims. Diverse approaches have been adopted to incorporate the effects of rotation in stellar evolution models. This study seeks to explore the consequences that these various prescriptions for rotation have for the essential outputs of massive star models.
Methods. We computed a grid of 15 and 60 M⊙ stellar evolution models with the Geneva Stellar Evolution Code that accounted for both hydrodynamical and magnetic instabilities induced by rotation.
Results. In the 15 and 60 M⊙ models, the choice of the vertical and horizontal diffusion coefficients for the nonmagnetic models strongly impacts the evolution of the chemical structure, but has a weak impact on the angular momentum transport and the rotational velocity of the core. In the 15 M⊙ models, the choice of the diffusion coefficient impacts the convective core size during the core H-burning phase, regardless of whether the model begins core He-burning as a blue or red supergiant and regardless of the core mass at the end of He-burning. In the 60 M⊙ models, the evolution is dominated by mass loss and is less strongly affected by the choice of the diffusion coefficient. In the magnetic models, magnetic instability dominates the angular momentum transport, and these models are found to be less strongly mixed than their rotating nonmagnetic counterparts.
Conclusions. Stellar models with the same initial mass, chemical composition, and rotation may exhibit diverse characteristics depending on the physics applied. By conducting thorough comparisons with observational features, we can ascertain which method(s) produce the most accurate results in different cases.
A catalogue of low-mass X-ray binaries in the Galaxy: From the INTEGRAL to the Gaia era
Authors: Fortin F. , Kalsi A. , García F. , Simaz-Bunzel A. , Chaty S. 
Published: February 2024

Context. Low-mass X-ray binaries (LMXBs) are high-energy sources that require multi-wavelength follow-up campaigns to be fully characterised. New transients associated with LMXBs are regularly discovered, and previously known systems are often revisited by astronomers to constrain their intrinsic parameters. All of this information compiled into a catalogue may build a useful tool for subsequent studies on LMXBs and their population.
Aims. We aim to provide an update on past LMXB catalogues dating back 16 yr and propose to the community a database on Galactic LMXBs with the most complete, manually curated set of parameters and their original references. On top of a fixed version accessible through Vizier, we propose hosting the catalogue independently on our GitHub collaboration, side-by-side with our previous catalogue on high-mass X-ray binaries. The database will be regularly updated based on new publications and community inputs.
Methods. We built a working base by cross-matching previous LMXB catalogues and supplementing them with lists of hard X-ray sources detected over the past 20 yr. We compiled information from Simbad on LMXBs as a starting point for a thorough, manual search in the literature to retrieve important parameters that characterize LMXBs. We retrieved newly detected LMXBs and candidates directly from literature searches. Counterparts to these LMXBs are compiled from hard X-ray to infrared and radio domains. Every piece of information presented on the LMXBs is curated and backed by accurate references.
Results. We present a catalogue of 339 Galactic LMXBs listing their coordinates, companion star spectral type, systemic radial velocity, component masses and compact object nature, the presence of type I X-ray bursts, as well as orbital data. Coordinates and identifiers of counterparts at various wavelengths are given, including 140 LMXBs detected in Gaia DR3.
Near-infrared spectroscopic characterisation of Gaia ultra-cool dwarf candidates
Authors: Ravinet T. , Reylé C. , Lagarde N. , Burgasser A. , Smart R. L. , Moya W. H. , Marocco F. , Scholz R.-D. , Cooper W. J. , Cruz K. L. , Fernández-Trincado J. G. , Homeier D. , Sarro L. M. 
Published: February 2024

Context. The local census of very low-mass stars and brown dwarfs is crucial to improving our understanding of the stellar-substellar transition and their formation history. These objects, known as ultra-cool dwarfs (UCDs), are essential targets for searches of potentially habitable planets. However, their detection poses a challenge because of their low luminosity. The Gaia survey has identified numerous new UCD candidates thanks to its large survey and precise astrometry.
Aims. We aim to characterise 60 UCD candidates detected by Gaia in the solar neighbourhood with a spectroscopic follow-up to confirm that they are UCDs, as well as to identify peculiarities.
Methods. We acquired the near-infrared (NIR) spectra of 60 objects using the SOFI spectrograph between 0.93 and 2.5 µm (R~ 600). We identified their spectral types using a template-matching method. Their binarity is studied using astrometry and spectral features.
Results. We confirm that 60 objects in the sample have ultra-cool dwarf spectral types close to those expected from astrometry. Their NIR spectra reveal that seven objects could host an unresolved coolest companion and seven UCDs share the same proper motions as other stars. The characterisation of these UCDs is part of a coordinated effort to improve our understanding of the Solar neighbourhood.
Regolith resurfacing and shedding on spinning spheroidal asteroids: Dependence on the surface mechanical properties
Authors: Dai Wen-Yue , Yu Yang , Cheng Bin , Baoyin Hexi , Li Jun-Feng 
Published: February 2024

Context. The Yarkovsky–O’Keefe–Radzievskii–Paddack (YORP) effect has been shown to effectively alter the rotational status of asteroids. The spin-up of the asteroid leads to surface instability and eventually triggers regolith failure, followed by landslide and mass shedding on the asteroid’s surface.
Aims. We explore the dynamics of the rotation-induced resurfacing and shedding, paying special attention to the dependence of post-shedding evolution on regolith mechanical properties, such as cohesion.
Methods. We propose a qualitative semi-analytical model to explore the post-failure dynamics of a fast-rotating asteroid. We also consider the interaction between the surface mass rearrangement and the asteroid’s spin status. We used our model to investigate the surface region where the failure occurs, as well as the total mass shed from the surface and the spin-down of the asteroid in this process.
Results. Based on our model, all the possible avalanche events following a regolith failure can be classified into four basic types: resurfacing (ReS), shedding and resurfacing (S&ReS), shed and bound (S-Bound), and shedding and escaping (S-Escp). Their corresponding regions in the parameter space are illustrated in this work. Our results show that although the regolith cohesion is very small (≲1–2 Pa), cohesion plays an important role in the onset of the avalanche. Moreover, our model qualitatively reconstructs the links between the regolith’s properties and the dynamical fates of the shed material. The timescale of YORP-induced shedding events is also discussed in this work.
Secondary halo bias through cosmic time
Authors: Balaguera-Antolínez Andrés , Montero-Dorta Antonio D. , Favole Ginevra 
Published: February 2024

Context. The spatial distribution of dark matter halos carries cosmological and astrophysical information. Cosmological information can be considered to be contained in the connection between halo main properties and the large-scale halo bias, while the astrophysical information would be encoded in the scaling relations between halo properties. The combination of these two contributions leads to the effect of secondary halo bias.
Aims. Our goal is to measure the signal of secondary halo bias as a function of a variety of intrinsic and environmental halo properties and to characterize its statistical significance as a function of cosmological redshift.
Methods. Using fixed and paired N-body simulations of dark-matter halos – the UNIT simulation – with masses above ∼1011 M⊙h−1 identified over a wide range of cosmological redshifts (0 < z < 5), we explored the behavior of the scaling relations among different halo properties. We included novel environmental properties based on the halo distribution as well as the underlying dark-matter field. We implemented an object-by-object estimator of large-scale effective bias and tested its validity against standard approaches. With a bias assigned to each tracer, we performed a statistical analysis aimed at characterizing the distribution of the bias and the signal of the secondary halo bias.
Results. We show how the halo scaling relations linking direct probes of the halo potential well do not depend on the environment. On the contrary, links between the halo mass and the so-called set of secondary halo properties are sensitive to the cosmological environment, mainly to under-dense regions. We show that the signal of secondary bias is derived statistically from secondary correlations beyond the standard link to the halo mass.
Conclusions. We show that the secondary bias arises through nonlocal and/or environmental properties related either to the halo distribution or to the properties of the underlying dark-matter field. In particular, properties such as the tidal field (a measure of the anisotropy of the density field) and the local Mach number (a measure of the local kinetic temperature of the halo distribution) generate the signals of the secondary bias with the highest significance. We propose applications of the assignment of individual bias for the generation of mock catalogs containing the signal of secondary bias, as well as a series of cosmological analyses aimed at mining large galaxy datasets.
Estudio de la influencia en la relación superficie/volumen durante el envejecimiento del Brandy de Jerez
Authors: Ollero Rocío Trillo , Gutiérrez Luis Miguel Trillo , Moreno M. Valme García , Sánchez Dominico A. Guillén 
Published: February 2024

Resumen
Uno de los parámetros físicos que más influye en la velocidad de envejecimiento de los aguardientes de vino, es la relación existente entre la superficie de la vasija y el volumen de líquido almacenado, En este trabajo se ha llevado a cabo el estudio de la importancia de la relación superficie/volumen en los procesos de extracción que tienen lugar durante la elaboración del Brandy de Jerez. Para ello se ha estudiado el envejecimiento de un aguardiente de 60% de grado alcohólico en vasijas de dos capacidades distintas, elaboradas en tres tipos de roble y envinadas y no envinadas previamente al envejecimiento. Los parámetros analizados en los aguardientes envejecidos han sido el Índice de Polifenoles Totales (IPT), los compuestos fenólicos individuales y el color. Estos valores están relacionados con el proceso de envejecimiento, aumentando a medida que lo hace el tiempo de estancia del aguardiente en las vasijas. Se ha observado que al aumentar la relación superficie/volumen, los aguardientes presentan mayores valores de estos parámetros, existiendo ligeras diferencias para cada tipo de roble estudiado. Por otro lado, el enviando de la vasija disminuye el aporte de compuestos fenólicos por parte de la madera al aguardiente.
Corona-Krise: Wie ist die Situation des Suchthilfesystems
danach?
Authors: Preuss Ulrich W. 
Published: February 2024

Liebe Leserinnen und Leserdie Corona-Pandemie hat das Leben aller und auch von Patienten mit Alkohol- und
Substanzkonsumstörungen deutlich verändert. Mit ihr gingen
zahlreiche Einschränkungen und Veränderungen einher. Besonders
schwer getroffen wurden diejenigen, die ohnehin schon mit Abhängigkeiten zu
kämpfen hatten. Ein besonders dramatisches Beispiel ist der Fall eines
alkoholabhängigen Patienten, der jahrelang trocken war und von einem gut
funktionierenden Netzwerk aus Selbsthilfegruppe und Suchtberatungsstelle
unterstützt wurde.
Vitamin E Does not Favor Recovery After Exercises: Systematic Review
and Meta-analysis
Authors: de Lima Katieli Santos , Schuch Felipe , Righi Natiele Camponogara , Neto Léo José Rubin , Nunes Guilherme Silva , Puntel Gustavo , Chagas Patrícia , da Silva Antonio Marcos Vargas , Signori Luis Ulisses 
Published: February 2024

AbstractThis review aimed to verify the effects of vitamin E supplementation on oxidative
stress, inflammatory response, muscle damage, soreness, and strength in healthy
adults after exercise. We searched the MEDLINE, EMBASE, SPORTDiscus, Cochrane
CENTRAL, and Web of Science from inception to August 2023, with no language
restrictions. We included randomized placebo-controlled trials evaluating the
supplementation of vitamin E on the abovementioned outcomes after a bout of
physical exercise in healthy participants (no restriction for publication year
or language). Meta-analyses were conducted to compare vitamin E and placebo
supplementations to obtain a 95% confidence interval (95%IC).
Twenty studies were included (n=298 participants). The effect of
supplementation was assessed between 0 h and 96 h after the exercise. Compared
to placebo, vitamin E had no effects on lipid (95%IC=
–0.09 to 0.42), protein (–2.44 to 3.11), SOD (–1.05 to
0.23), interleukin-6 (–0.18 to 1.16), creatine kinase (–0.33 to
0.27), muscle soreness (–1.92 to 0.69), and muscle strength
(–1.07 to 0.34). Heterogeneity for the analyses on carbonyls,
interleukin-6 (1 h and 3 h), and muscle soreness ranged between 70 to
94%. Supplementing with vitamin E should not be recommended to support
the recovery process in healthy individuals after exercise, given the lack of
efficacy in the analyzed variables following an exercise session.
Structured image diagnosis of vertebral body degeneration and intervertebral disc damage – Binary image criteria and comparison for systematic image analysis for occupational diseases 2108 and 2110
Authors: Braunschweig Rainer , Kildal Daniela , Meyer-Clement Michael , Tiemann Andreas , Janka Rolf 
Published: February 2024

Background Job-related limitations of earning capacity are eligible for recognition under social legislation and may be subject to compensation (see Part 1).
Method For the recognition of an occupational disease (BK), diagnostic imaging is required as part of the legal determination procedure for occupational diseases 2108/2110 (“occupational disc disease”). The focus is on image criteria on X-ray images and MRI examinations. In a consensus paper under the guidance of the German Social Accident Insurance Institutions from 2005, the characteristic patterns are defined and explained extensively and summarized in typical occupation-related constellations. This article presents representative image examples as a reference system for expert reporting as far as the typical patterns from the consensus paper are concerned.
Conclusion In Part 2, comparison images with the typical findings of the vertebral bodies and intervertebral discs according to occupational diseases are systematically presented, explained, and offered as a reference system for expert assessment. The image criteria can be used as “evidence by eye” (Heuck) in the recognition procedure.
Key Points

Citation Format
Psychomotor and Cognitive Outcome in Very Preterm Infants in Vorarlberg, Austria, 2007–2019
Authors: Jenni Fabio , Konzett Karin , Gang Stefanie , Sparr Verena , Simma Burkhard 
Published: February 2024

Abstract
Aim The aim of this study was to analyze neurodevelopmental outcome of very and extremely preterm infants in Vorarlberg, Austria, accessed with neurodevelopmental testing, at the corrected age of 24 months. This article also compared these results with (inter)national data and analyzed the impact of perinatal parameters.
Methods Population-based, retrospective multicenter study with data on very and extremely preterm infants born in Vorarlberg from 2007 to 2019 assessed with Bayley Scales of Infant Development (BSID-II/Bayley-III).
Results Included were 264 infants with a mean age of 29.0 (± 2.1) weeks of gestational age and a mean birth weight of 1177 (± 328.26) g; 172 infants underwent a BSID-II, 92 a Bayley-III assessment. The psychomotor developmental index (PDI) and mental developmental index (MDI) showed mean scores of 99.6 (± 14.4) and 91 (± 20.4), respectively. Adverse outcomes (scores <70) were assessed in 4.2% for PDI and 15.5% for MDI. In the extremely preterm group (n = 79), results for mean PDI were 100.1 (± 16.8) and for mean MDI 88.4 (± 22.4). Accordingly, adverse outcomes were assessed in 5.1% for PDI and in 20.3% for MDI. In addition to bronchopulmonary dysplasia and intraventricular hemorrhage Grade 3-4, head circumference at birth and patent ductus arteriosus were also identified as risk factors for poor outcome.
Conclusion This study showed a remarkably good neurodevelopmental outcome in preterm infants with low rates of adverse outcome, similar to (inter)national reports, especially in the group of extremely preterm infants. Research is needed to explore the role of social factors and infants' environment, especially cognitive outcome and language skills.