bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Proxy Minerals for Evaluation of the Oxygen Isotope Composition of Felsic Melts
Authors: Dubinina E. O. , Aranovich L. Ya. 
Published: November 2023

AbstractThe problems associated with the use of quartz and zircon as proxy minerals for the reconstruction of δ18O values in acidic melts are considered. It is shown that the correction values Δ(Qz–R) and Δ(R–Zrn) used for the reconstructions are not strictly constant and depend on the mineral composition of the rock and the closure temperature of the oxygen isotopic system of the proxy mineral (Tq, Tz–closure temperature of quartz and zircon, respectively). The applicability of quartz was estimated using an equation for Δ(Qz–R) calculation, which takes into account Tq and the mineral composition of rocks. Using the leucogranites of the Raumid massif (South Pamirs) as an example, it was shown that this correction can be approximated by constant value only under definite conditions. The value of Δ(R–Zrn) was estimated using approach based on calculating the weighted average fractionation coefficient and independent estimates Tz using a zirconium thermometer. It was shown for leucogranite porphyries of the Omsukchan trough that this correction for identical rocks varies from 1.3 to 1.9 ‰, unlike Δ(R–Zrn) = 2.1 determined by the dependence on the SiO2 content (Lackey et al., 2008). The advantages and limitations on the application of quartz and zircon as proxy minerals have been analyzed.
Age-matched analysis of axial length growth in myopic children wearing defocus incorporated multiple segments spectacle lenses
Authors: Graff Birte , Lam Carly S Y , Vlasak Natalia , Kaymak Hakan 
Published: November 2023

Background/aimsDefocus incorporated multiple segments (DIMS) spectacle lenses are known to be able to inhibit axial length (AL) growth in myopic children compared with single vision (SV) spectacle lenses. However, it is not known whether AL growth is sufficiently inhibited to achieve the treatment goal of physiological AL growth.MethodsOf the data already collected in 2014–2017 by Lamet al, the AL growth with DIMS and SV spectacle lenses was re-evaluated according to the age-matched myopia control system. The individual AL growth after the first year of treatment of each eye was plotted against the corresponding age of the same time point in a colour-coded scheme. The two treatment groups were further subdivided based on their age and their baseline AL.ResultsOverall, 65% (61% of male, 70% of female) of eyes with DIMS spectacle lenses and 16% (16% of male, 16% of female) of eyes with SV spectacle lenses are within range of physiological AL growth rate. Median AL growth rate of eyes with DIMS spectacle lenses is also within the range of physiological growth. In the subgroups, eyes with DIMS spectacle lenses were also superior to the ones with SV spectacle lenses regarding this treatment goal. Of the children with SV spectacle lenses, older children and children with eyes with high baseline AL were least likely to achieve physiological AL growth rate.ConclusionsDIMS spectacle lenses can bring the AL growth rate of myopic children to the level of physiological AL growth rate, indicating 100% reduction of excessive myopic AL growth, independent of age and baseline AL. Older children and children with eyes with high AL have the risk to have increased AL growth without treatment.
Head-to-head comparative study: evaluating three panels for MSI-PCR testing in patients with colorectal and gastric cancer
Authors: Fu Xinhui , Huang Jinglin , Fan Xinjuan , Wang Chao , Deng Weihao , Tan Xiaoli , Chen Zhiting , Cai Yacheng , Hanjie Lin , Xu Liang , Zou Jiaxin , Zhan Huanmiao , Huang Shuhui , Fang Yongzhen , Huang Yan 
Published: November 2023

AimsDue to the lack of large clinical cohorts in the Chinese populations with colorectal cancer (CRC) and gastric cancer (GC), there is no consensus among the preferred panel for microsatellite instability (MSI)-PCR testing. This study aims to evaluate a more appropriate panel.MethodsWe tested the MSI status of 2572 patients with CRC and GC using the NCI panel and 2 mononucleotide panels (5 and 6 mononucleotide panels). Immunohistochemistry (IHC) was employed to perform mismatch repair protein testing in 1976 samples.ResultsWe collected 2572 patients with CRC and GC. The National Cancer Institute (NCI) panel failed to detect 13 cases. Of the 2559 cases that received results from all three panels, 2544 showed consistent results. In the remaining 15 cases, 9 showed discrepancies between MSI-H and MSI-L, and 6 showed discrepancies between MSI-L and microsatellite stability (MSS). The misdiagnosis rate of MSI-L was significantly lower in two mononucleotide panels than in the NCI panel (12.5% vs 87.5%, p=0.010) in CRC. In patients with GC, only the NCI panel detected three MSI-L cases, while the results of the two mononucleotide panels were one MSI-H and two MSS. Based on their IHC results, the MSI-L misdiagnosis rate of the NCI panel was 33.3%. Furthermore, compared with two mononucleotide panels, the NCI panel had a much lower rate of all loci instability in CRC (90.8% and 90.3% vs 25.2%) and GC (89.5% and 89.5% vs 12.0%).ConclusionIn Chinese patients with CRC and GC, the five and six mononucleotide panels have advantages for detecting MSI over the NCI panel.
The electronic structure of 2(5H)-thiophenone investigated by vacuum ultraviolet synchrotron radiation and theoretical calculations
Authors: Kumar S. , Duflot D. , Jones N. C. , Hoffmann S. V. , García G. , Limão-Vieira P. 
Published: November 2023

AbstractThe electronic state spectroscopy of 2(5H)-thiophenone, C4H4OS, has been investigated by high-resolution vacuum ultraviolet photoabsorption in the 3.76–10.69 eV energy range using synchrotron radiation, together with novel quantum chemical calculations performed at the equation of motion coupled cluster singles and doubles (EOM-CCSD) level of theory. The major electronic transitions have been assigned to valence and Rydberg character, with relevant C=O, C=C and C–C stretching vibrations across the entire absorption spectrum. Photolysis lifetimes in the Earth’s atmosphere (0–50 km altitude) have been estimated from the absolute photoabsorption cross-sections, indicating that solar photolysis can be expected to be a strong sink mechanism.
Graphical abstract
Coupling the Navier–Stokes–Fourier equations with the Johnson–Segalman stress-diffusive viscoelastic model: Global-in-time and large-data analysis
Authors: Bathory Michal , Bulíček Miroslav , Málek Josef 
Published: November 2023

We prove that there exists a large-data and global-in-time weak solution to a system of partial differential equations describing the unsteady flow of an incompressible heat-conducting rate-type viscoelastic stress-diffusive fluid filling up a mechanically and thermally isolated container of any dimension. To overcome the principal difficulties connected with ill-posedness of the diffusive Oldroyd-B model in three dimensions, we assume that the fluid admits a strengthened dissipation mechanism, at least for excessive elastic deformations. All the relevant material coefficients are allowed to depend continuously on the temperature, whose evolution is captured by a thermodynamically consistent equation. In fact, the studied model is derived from scratch using only the balance equations for linear momentum and energy, the formulation of the second law of thermodynamics and the constitutive equation for the internal energy. The latter is assumed to be a linear function of temperature, which simplifies the model. The concept of our weak solution incorporates both the temperature and entropy inequalities, and also the local balance of total energy provided that the pressure function exists.
Korn–Maxwell–Sobolev inequalities for general incompatibilities
Authors: Gmeineder Franz , Lewintan Peter , Neff Patrizio 
Published: November 2023

We establish a family of coercive Korn-type inequalities for generalized incompatible fields in the superlinear growth regime under sharp criteria. This extends and unifies several previously known inequalities that are pivotal to the existence theory for a multitude of models in continuum mechanics in an optimal way. Different from our preceding work [F. Gmeineder, P. Lewintan and P. Neff, Optimal incompatible Korn–Maxwell–Sobolev inequalities in all dimensions, Calc. Var. PDE 62 (2023) 182], where we focused on the case [Formula: see text] and incompatibilities governed by the matrix curl, the case [Formula: see text] considered in this paper gives us access to substantially stronger results from harmonic analysis but conversely deals with more general incompatibilities. Especially, we obtain sharp generalizations of recently proved inequalities by P. Lewintan, S. Müller and P. Neff [Korn inequalities for incompatible tensor fields in three space dimensions with conformally invariant dislocation energy, Calc. Var. PDE 60 (2021) 150] in the realm of incompatible Korn-type inequalities with conformally invariant dislocation energy. However, being applicable to higher-order scenarios as well, our approach equally gives the first and sharp inequalities involving Kröner’s incompability tensor inc.
EEGManyPipelines: A Large-scale, Grassroots Multi-analyst Study of Electroencephalography Analysis Practices in the Wild
Authors: Trübutschek Darinka , Yang Yu-Fang , Gianelli Claudia , Cesnaite Elena , Fischer Nastassja L. , Vinding Mikkel C. , Marshall Tom R. , Algermissen Johannes , Pascarella Annalisa , Puoliväli Tuomas , Vitale Andrea , Busch Niko A. , Nilsonne Gustav 
Published: November 2023

Abstract
The ongoing reproducibility crisis in psychology and cognitive neuroscience has sparked increasing calls to re-evaluate and reshape scientific culture and practices. Heeding those calls, we have recently launched the EEGManyPipelines project as a means to assess the robustness of EEG research in naturalistic conditions and experiment with an alternative model of conducting scientific research. One hundred sixty-eight analyst teams, encompassing 396 individual researchers from 37 countries, independently analyzed the same unpublished, representative EEG data set to test the same set of predefined hypotheses and then provided their analysis pipelines and reported outcomes. Here, we lay out how large-scale scientific projects can be set up in a grassroots, community-driven manner without a central organizing laboratory. We explain our recruitment strategy, our guidance for analysts, the eventual outputs of this project, and how it might have a lasting impact on the field.
The diagnostic performance of micro-RNA and metabolites in lung cancer: A meta-analysis
Authors: Mlika Mona , Zorgati Mohamed Majdi , Abdennadher Mehdi , Bouassida Imen , Mezni Faouzi , Mrabet Ali 
Published: November 2023

Background The diagnosis of lung cancer is based on the microscopic exam of tissue or liquid. During the recent decade, many biomarkers have been pointed to have a potential diagnostic role. These biomarkers may be assessed in blood, pleural effusion or sputum and they could avoid biopsies or other risky procedures. The authors aimed to assess the diagnostic performances of biomarkers focusing on micro-RNA and metabolites. Methods This meta-analysis was conducted under the PRISMA guidelines during a nine-year-period (2013–2022). the Meta-Disc software 5.4 (free version) was used. Q test and I2 statistics were carried out to explore the heterogeneity among studies. Meta-regression was performed in case of significant heterogeneity. Publication bias was assessed using the funnel plot test and the Egger's test (free version JASP). Results According to our inclusion criteria, 165 studies from 79 articles were included. The pooled SEN, SPE and dOR accounted, respectively, for 0.76, 0.79 and 13.927. The AUC was estimated to 0.859 suggesting a good diagnostic accuracy. The heterogeneity in the pooled SEN and SPE was statistically significant. The meta-regression analysis focusing on the technique used, the sample, the number of biomarkers, the biomarker subtype, the tumor stage and the ethnicity revealed the biomarker number ( p  =  0.009) and the tumor stage ( p  =  0.0241) as potential sources of heterogeneity. Conclusion Even if this meta-analysis highlighted the potential diagnostic utility of biomarkers, more prospective studies should be performed, especially to assess the biomarkers’ diagnostic potential in early-stage lung cancers.
A multi-dimensional study of organisational boundaries and silos in the healthcare sector
Authors: Pedersen Esben Rahbek Gjerdrum , Sudzina Frantisek , Rosati Francesco 
Published: November 2023

Purpose: The aim of this study is to understand how healthcare practitioners experience organisational boundaries and silos in day-to-day operations. Based on a multi-dimensional scale of organisational boundaries, the study examines how organisational demarcation lines enable and constrain daily work tasks in the healthcare sector. Research design: The study is based on a quantitative and qualitative analysis of survey responses from 895 healthcare practitioners in Denmark. Results: The results indicate that tendencies toward organisational silos relate to systems and hierarchies (management-staff) rather than professions and departments. Moreover, the study identifies resource scarcity as an important undercurrent in the understanding of the respondents’ perceptions of boundaries and silos. Conclusion: The study contributes to existing research by documenting the coordination and collaboration challenges linked to the multitude of demarcation lines in complex health organisations.
End-of-Life Medical Decisions: The Link Between Sociodemographic Characteristics and Treatment Preferences
Authors: Shayya Ashley , Young Yuchi 
Published: November 2023

Introduction Advance directives (ADs) promote patient autonomy in end-of-life (EOL) care, including an individual’s EOL medical treatment preferences. This study aims to better understand preferences regarding EOL medical treatment among community-dwelling adults (18 and older) residing in the United States and examine the association between sociodemographic characteristics and EOL medical treatment preferences. Methods Utilizing a cross-sectional study and snowball sampling methodology, community-dwelling adults completed a survey containing two different ADs and a questionnaire with sociodemographic information. Univariate analyses were used to summarize EOL medical treatment preferences among the sample, and bivariate analyses (Chi-square and Fisher’s Exact tests) were performed to examine the association between sociodemographic characteristics (age, gender, and race/ethnicity) and EOL medical treatment preferences. Results The mean age of the 166 participants was 50 (SD: 21.65, range: 18-93), with 58.4% being White and 61.4% being female. Generally, when EOL scenarios involved brain damage or a coma, more participants indicated that they did not want life-support treatment. Age and race were both associated with EOL medical treatment preferences, but no significant differences were observed in the bivariate results by gender. Largely, young and middle-aged adults, along with Black participants, were more likely to prefer more aggressive EOL medical treatments than older adults and White participants. Conclusion Overall, EOL medical treatment preferences varied among participants. The study findings indicate that adults develop different preferences for EOL medical treatment, with some of the variation attributable to sociodemographic characteristics such as age and race.
Cytokeratin 7 Expression and Mismatch Repair Status for Survival Prediction in Patients With Low Rectal Cancer After Neoadjuvant Therapy
Authors: Shi Songli , Zhou Mingming , Wang Gang , Xu Jinling , Zhang Dan , Zheng Minying , Zhang Shiwu 
Published: November 2023

Background More than half of the patients with locally advanced low rectal cancer exhibit no or minor response to nCRT. It is important to investigate the predictive and prognostic values of potential biomarkers in patients with locally advanced low rectal cancer receiving nCRT. Materials and Methods This retrospective study included 162 patients with locally advanced low rectal cancer who underwent nCRT, followed by total mesorectal excision (TME) between 2016 and 2019. Cytokeratin 7 (CK7) expression and mismatch repair (MMR) status were determined by immunohistochemistry (IHC). Categorical variables were compared using the chi-square test. Overall survival (OS) and disease-free survival (DFS) curves were estimated using the Kaplan–Meier and Cox methods. Results There were predominance significant differences in distance from anus margin ( P < .0001) and circumferential extent of the tumor ( P < .0001).CK7 positive expression was detected in 21 of the 162 patients (13%). The univariate and multivariate analysis revealed that patients whose tumors had CK7 positive expression had significantly shorter OS (HR = 3.878, P = .038; HR = 1.677 , P = .035) and DFS (HR = 3.055, P = .027;HR = 3.569 , P = .038) than those with CK7 negative expression. While patients with CK7 positive expression had a higher proportion of worse TRG compared with CK7 negative patients ( P = .001). Patients with deficient mismatch repair (dMMR) just occupied a small proportion (8.6%), but there was still a close connection between the MMR status and recurrence after TME ( P = .045). MMR status was an independent risk factor affecting the OS (HR = .307, P < .0001; HR = .123 , P < .0001) and DFS (HR = .288, P < .0001; HR = .286 , P < .0001) by univariate and multivariate analysis. But no significant difference in the proportion of TRG was observed between patients with dMMR and pMMR ( P = .920). Conclusions The result confirms negative prognostic role of CK7-positive and dMMR statuses, which have potential predictive value for neoadjuvant chemoradiotherapy response. This provides opportunity to modify individualized treatment strategies for patients with different CK7 expression levels and dMMR statuses.
Effect of High-Dose Drug-Coated Balloon Repetition After Drug-Coated Balloon Failure
Authors: Tomoi Yusuke , Takahara Mitsuyoshi , Soga Yoshimitsu , Hirano Taichi , Tsunoda Kazuki , Katsuki Tomonori , Ando Kenji 
Published: November 2023

Purpose: Although the optimal treatment for femoropopliteal (FP) drug-coated balloon (DCB) restenosis lesions remains debatable, the effectiveness of DCB repetition for DCB restenosis has been reported. However, the optimal DCB repetition strategy is not yet established. Thus, this study aimed to compare the clinical outcomes of high-dose DCB repetition with those of low-dose DCB repetition for FP DCB restenosis lesions. Materials and Methods: This single-center, observational study used a clinical database of 677 consecutive patients undergoing FP endovascular intervention for symptomatic peripheral artery disease between December 2018 and December 2021. Of these patients, 89 cases treated with DCB repetition for FP DCB restenosis lesions were analyzed. The primary endpoint was recurrent restenosis (re-restenosis) and the secondary endpoints were recurrent target-lesion revascularization (TLR), re-occlusion, and major adverse limb events (MALE) obtained using propensity score matching. Interaction analysis was also performed to explore the effects of the baseline characteristics on the association between high- and low-dose DCB with restenosis risk. Results: After propensity score matching, high-dose DCB demonstrated a significantly higher freedom from re-restenosis compared with low-dose DCB repetition at 1 year (90.4% vs 40.9%, p=0.034). In addition, freedom from re-TLR and MALE at 1 year was significantly higher in the high-dose DCB group (95.0% vs 53.3%, p=0.025; 95.0% vs 54.7%, p=0.025, respectively). Conversely, freedom rates from re-occlusion were not significantly different between the 2 groups (100.0% vs 84.0%, p=0.99). No baseline characteristics or perioperative outcomes had any significant interaction effect on the association of high-dose DCB versus low-dose DCB with restenosis risk. Conclusion: For FP DCB restenosis lesions, high-dose DCB repetition offered more favorable outcomes than low-dose DCB repetition. Clinical Impact This study revealed that for femoropopliteal drug-coated balloon (DCB) restenosis lesions, high-dose DCB repetition obtained more favorable outcomes than low-dose DCB repetition. In addition, there was no significant interaction effect on the association of high- versus low-dose DCB with re-restenosis risk for the baseline characteristics and perioperative outcomes. This finding might be also a reason for choosing high-dose DCB repetition for FP DCB restenosis lesions in daily clinical practice.
Techniques and Limitations of Gore Thoracoabdominal Multibranch Endoprosthesis (TAMBE) for Type 1A Endoleak After Failed Endovascular Aortic Repairs
Authors: Han Sukgu M. , DiBartolomeo Alexander D. , Chavez Marin , Meltzer Andrew J. 
Published: November 2023

Purpose: Endovascular aortic aneurysm repair (EVAR) is the dominant treatment modality over open repair for abdominal aortic aneurysms. However, a higher rate of reinterventions remains the Achilles heel of EVAR. Although type 1A endoleak from proximal seal zone failure of EVAR remains one of the leading causes for reintervention, fenestrated branched devices suitable for proximal extension of failed EVAR are not widely available in the United States. Gore Thoracoabdominal Multibranch Endoprosthesis (TAMBE) is an off-the-shelf investigational device that provides supraceliac seal by incorporating 4 visceral and renal arteries via preloaded inner branches. Case Report: In this article, we describe 2 cases of type 1A endoleak from previous EVAR devices repaired using TAMBE. Both cases were performed under the Food and Drug Administration (FDA) compassionate use exemption. Considerations on the case planning and implantation techniques of TAMBE specific to previous EVAR devices are reviewed. Conclusions: Gore TAMBE can be utilized to repair a type 1A endoleak of a previous infrarenal EVAR device. Greater supraceliac coverage necessary for TAMBE relative to the minimal seal zone should be considered when applying this device for a type 1A endoleak. Clinical Impact This report demonstrates the feasibility of applying off-the-shelf TAMBE device to treat one of the most common failure modes of EVAR, type1A endoleak.
Outcomes of the Latarjet procedure in female patients: A case series and matched-pair analysis
Authors: Berk Alexander N , Ifarraguerri Anna M , Rao Allison J , Dib Aseel G , Hysong Alexander A , Meade Joshua D , Trofa David P , Fleischli James E , Schiffern Shadley C , Hamid Nady , Saltzman Bryan M 
Published: November 2023

Background The objective of this study was to retrospectively report on the outcomes of female patients undergoing the Latarjet procedure. Methods Female patients undergoing the Latarjet procedure with minimum 1 year follow-up were identified and contacted to obtain Numeric Pain Rating Scale (NPRS), Subjective Shoulder Value (SSV), and return to sport (RTS) data. Eligible females were then matched 1:1 with a male counterpart based on laterality and age (± 3 years), and outcomes compared. Results A total of 20 female patients with a mean follow-up of 73.8 months reported postoperative NPRS and SSV scores of 2.2  ±  2.3 and 69.3  ±  22.0, respectively. Of the nine athletes, 3 (33%) reported a successful RTS at a mean of 9 months. Four patients (20.0%) required reoperation at a mean of 27.1 months. The matched analysis demonstrated similar NPRS scores between male and female patients and a trend towards lower SSV scores and rates of RTS. Conclusion At mid-term follow-up female patients reported pain levels similar to female-specific literature reports, but overall low subjective shoulder function and RTS. Compared to propensity-matched males, females reported similar levels of pain, lower shoulder function, and lower rates of RTS, however, differences did not reach statistical significance. Level of Evidence IV, retrospective case series.