bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geometric Feature of DNA Sequences
Authors: Xu Hongjie 
Published: October 2023

Background::
The primary goal of molecular phylogenetics is to characterize the similarity/
dissimilarity of DNA sequences. Existing sequence comparison methods with some patented
are mostly alignment-based and remain computationally arduous.

Objective::
In this study, we propose a novel alignment-free approach based on a previous DNA
curve representation without degeneracy.

Method::
The method combines two important geometric elements that describe the global and
local features of the curve, respectively. It allows us to use a 24-dimensional vector called a characterization
vector to numerically characterize a DNA sequence. We then measure the dissimilarity/
similarity of various DNA sequences by the Euclidean distances between their characterization
vectors.

Results::
we compare our approach with other existing algorithms on 4 data sets including
COVID-19, and find that our apporach can produce consistent results and is faster than the
alignment-based methods.

Conclusion::
The method stated in this study, can assist in analyzing biological molecular sequences
efficiently and will be helpful to molecular biologists.
The Impact of HAPPY (Humanity Assurance Protocol in Interventional
Radiotherapy) on the Psychological Well-being of Gynecological Cancer
Patients
Authors: Tagliaferri Luca , Mancini Silvia , Lancellotta Valentina , Dinapoli Loredana , Capocchiano Nikola , Cornacchione Patrizia , Scalise Sara , Autorino Rosa , Campitelli Maura , Colloca Giuseppe Ferdinando , Fionda Bruno , Rovirosa Angeles , Macchia Gabriella , Ferrandina Gabriella , Gambacorta Maria Antonietta 
Published: October 2023

Background:
HAPPY (Humanity Assurance Protocol in Interventional Radiotherapy)
reports the necessity for gynecological cancer patients to undergo interventional radiotherapy
(IRT, also called brachytherapy). The present paper has evaluated how some precautions may
improve the psychological well-being of the patients during IRT.

Methods:
Patients with gynecological cancer undergoing IRT-HDR were analyzed. Patients answered
three questionnaires before the IRT procedure (T0) and at the end of IRT (T1): Distress
Thermometer (DT), Numerical Rating Scale for IRT procedure distress (NRS), and Hospital Anxiety
and Depression Scale (HADS). Correlations have been calculated pairwise through pandas.
corrwith with a Pearson algorithm, and the p-values have been calculated through
scipy.stats.pearsonr. Plots have been generated through seaborn and matplotlib. A Wilcoxon test
was used.

Results:
55 patients were selected for this study. The median age of the patients was 64 (range,
39-84) years. 52 patients were with stage I endometrial cancer, whereas 3/3 patients with cervical
cancer had locally advanced stages (IIB-IVA). 26 patients had a high education level (47.3%), and
38 were married or with a partner (69.1%). Only 14/55 (25.45%) patients were working. The
HADS, DT, and NRS averages before the IRT procedure (T0) were 10.2, 3.8, and 4.3, respectively.
After applying the HAPPY protocol, the HADS, DT, and NRS averages after IRT (T1) were
9.4, 3.4, and 2.6, respectively. The Wilcoxon signed rank test analysis showed a significant improvement
in NRS (p < 0.00001) and HADS (p = 0.034). Living with a partner, parents or relatives
was the only parameter statistically significantly associated with better DT pre-IRT (p =
0.04), HADS pre-IRT (p = 0.01), DT post-IRT (p = 0.01), and HADS post-IRT (p = 0.04).

Conclusion:
In our study, the HAPPY protocol was associated with a significant reduction in
patients’ distress, anxiety, and discomfort.
Recent Advances in Combating Acne with Novel Drug Delivery Systems:
A Review
Authors: D'Sa Melroy , Mahadik Shreyash S. , Patel Nrupesh , Nadar Sahaya 
Published: October 2023

Abstract:
Acne vulgaris is an inflammatory disorder of the skin that occurs when hair follicles get clogged with sebum and dead skin cells resulting in pustules, papules, or nodules. This condi-tion affects a large number of people throughout the world. Over time, various conventional ther-apies like topical, systemic and hormonal treatments have been prescribed by doctors to patients for managing acne. Amongst these, topical therapy is the first-line therapy dominated by retinoid and antibiotic drugs. However, conventional topical treatments have many drawbacks concerning physicochemical instability, poor ability to penetrate the skin, and wide-ranging side effects. Novel drug delivery systems are the formulations that were first devised to overcome the issues faced by traditional methods. Researchers have developed novel therapies for topical use, such as niosomes, transfersomes, solid lipid nanoparticles, microsponges, microemulsion, microspheres, nanocochleates, and liposomes, which can be used to target acne. These nanoparticulate systems aim to overcome the disadvantages of conventional treatment and provide higher safety and effi-cacy, along with an increase in the stability of the formulation. Many comparative studies have been conducted between the novel and conventional methods, which give us a better understand-ing of the safety and efficacy of drugs present in the formulation and prove that novel drug deliv-ery systems are more favorable than their conventional counterparts. This review article provides a brief insight into the conventional methods, discusses in depth the earlier mentioned novel ther-apies that can be used successfully in treating acne, and provides patent information on the drug delivery systems.
Case study on Gridhrasi with Mahanimba Mula Twak Ghana Vati
Authors: Bibi Rukshana , Gupta Poonam 
Published: October 2023

Background: Low back pain is one of the most common complaints in India that affects with 70% to 80% of the population. Among the various causes of low back pain, the intervertebral disc prolapsed is the most common and the pain may be confined in the lower back only or referred to as a leg, buttock or hip which often outline the features of Sciatica syndrome. In Ayurvedic Science, the disease Sciatica can be compared with Gridhrasi which is one of the most common disorders of Vata. Aims & Objectives: This study aimed to access the efficacy of Ayurvedic management including Shodhana and Shamana Chikitsa in Gridhrasi. Materials and Methods: It is a single case study. A 45-year married man who has already been diagnosed with a bulge with superimposed right paracentral protrusion of L4-L5, correlated with Ghridrasi of the right leg from 5 months approached to our Ayurvedic hospital. He was treated with Panchakarma treatment including Yoga Basti, Kati Basti along with Shamana Chikitsa for one month. Results: Symptomatic assessment of patient was carried out after one month and satisfactory outcome was there and overall quality of life of patient was significantly improved. Conclusion: The after mentioned therapy gives symptomatic relief for the management of Gridhrasi.
Aiding and Abetting in Suicide Among Children and Adolescents
Authors: Majchrzak Katarzyna 
Published: October 2023

An increasing number of children and young people are committing suicide. Very often this occurs as a result of persuasion or with the provision of aid by peers. The purpose of this article is to introduce and explain the most important issues related to the offence under Article 151 of the Criminal Code. The perpetrator of the criminal act in question leads another person to take his or her own life. At the same time, it is not necessary for death to occur. The mere taking of actions directly aimed at suicide is sufficient.
Persuasion involves inducing another person to take his or her own life. The persuasion should be explicit in oral or written form. Providing assistance, on the other hand, may consist of providing a measure, giving advice or guidance.
Acceptability of a Self-Led Mindfulness-Based Intervention for Teens with Type 1 Diabetes: Pilot Randomized Controlled Trial
Authors: Humiston Tori , Cummings Caroline , Suss Stephen , Cohen Laura B , Hazlett-Stevens Holly , Hughes Lansing Amy 
Published: October 2023

Background
Diabetes distress among adolescents with type 1 diabetes has been associated with suboptimal diabetes outcomes, including lower quality of life, increased diabetes self-management challenges, and suboptimal glycemic outcomes.

Objective
This study examined the feasibility and acceptability of a scalable self-led mindfulness-based intervention to reduce diabetes distress in adolescents with type 1 diabetes.

Methods
Adolescents (N=25) aged between 14 and 18 years diagnosed with type 1 diabetes completed a baseline assessment. Participants were randomized to receive a 10-week self-guided mindfulness-based stress reduction workbook program (e-book or paper option) immediately (n=15) or after a 10-week wait (n=10). During the intervention period, participants completed weekly assignments and feedback surveys. At 10 weeks and 20 weeks, follow-up assessments were completed.

Results
Findings indicated that participants did not find the original intervention feasible or acceptable. Adolescents reported barriers to completing the weekly material, such as that they forgot or that the material was not sufficiently related to their diabetes management. Adolescents also reported that a digital format rather than a workbook or e-book may be more acceptable. Results from weekly surveys provided the foundation for recommendations for future iterations of the mindfulness-based intervention for adolescents with type 1 diabetes.

Conclusions
Participant feedback informed recommendations for self-led mindfulness programs for youth with type 1 diabetes. Adolescents indicated that a shorter, digital mindfulness-based intervention focused on diabetes-specific behaviors may be more helpful.

Trial Registration
ClinicalTrials.gov NCT05115175; https://clinicaltrials.gov/study/NCT05115175
Factors Associated With Work Engagement of Nurses During the Fifth Wave of the COVID-19 Pandemic in Japan: Web-Based Cross-Sectional Study
Authors: Muroi Kei , Ishitsuka Mami , Hachisuka Tomoko , Shibata Itsuka , Ikeda Tomohiko , Hori Daisuke , Doki Shotaro , Takahashi Tsukasa , Sasahara Shin-ichiro , Matsuzaki Ichiyo 
Published: October 2023

Background
The COVID-19 pandemic has brought to light the prevalence of mental health issues among nurses. Work engagement (WE) is a concept that describes work-related positive psychological states and is of importance within mental health measures. There is, however, a lack of research on factors associated with the WE of nurses during the COVID-19 pandemic.

Objective
We aimed to determine which factors are associated with WE among nurses during the COVID-19 pandemic using the job demands-resources (JD-R) model as a framework.

Methods
A web-based cross-sectional survey was conducted among nurses working in acute care and psychiatric institutions in the prefectures of Chiba and Tokyo in Japan. The survey period occurred between August 8 and September 30, 2021, during a time when the number of patients with a positive COVID-19 infection increased. The 3-item version of the Utrecht Work Engagement Scale (UWES-3) was used to measure WE. Factors such as age, gender, years of experience, affiliated ward, COVID-19–related stress, financial rewards from the government and hospital, encouragement from the government and patients, and workplace social capital were assessed. A total of 187 participants were included in the final analysis. Multiple regression analysis was performed to examine the factors related to WE. Partial regression coefficients (B), 95% CI, and P values were calculated.

Results
The mean overall score for the UWES-3 was 3.19 (SD 1.21). Factors negatively associated with UWES-3 were COVID-19–related stress on work motivation and escape behavior (Β –0.16, 95% CI –0.24 to –0.090; P<.001), and factors positively associated with UWES-3 were affiliation of intensive care units (Β 0.76, 95% CI 0.020-1.50; P=.045) and financial rewards from the government and hospital (Β 0.40, 95% CI 0.040-0.76; P=.03).

Conclusions
This study examined factors related to WE among nurses during the COVID-19 pandemic using the JD-R model. When compared with findings from previous studies, our results suggest that nurses’ WE was lower than before the COVID-19 pandemic. Negative motivation and escape behaviors related to COVID-19 were negatively associated with WE, while there were positive associations with financial rewards from the government and hospital and affiliation with an intensive care unit. Further research into larger populations is needed to confirm these findings.
Coadaptation Between Smart Technologies and Older Adults Over Time: Protocol for a Scoping Review
Authors: Kokorelias Kristina Marie , Grigorovich Alisa , Harris Maurita T , Rehman Umair , Ritchie Louise , Levy AnneMarie , Denecke Kerstin , McMurray Josephine 
Published: October 2023

Background
The Internet of Things (IoT) has gained significant attention due to advancements in technology and has potential applications in meeting the needs of an aging population. Smart technologies, a subset of IoT, can support older adults in aging in place, promoting independent living and improving their quality of life. However, there is a lack of research on how older adults and smart technologies coadapt over time to maximize their benefits and sustain adoption.

Objective
We will aim to comprehensively review and analyze the existing scientific literature pertaining to the coadaptation between smart technologies and older adults. The primary focus will be to investigate the extent and nature of this coadaptation process and explore how older adults and technology coevolve over time to enhance older adults' experience with technology.

Methods
This scoping review will follow the methodology outlined in the Joanna Briggs Institute Reviewer's Manual and adhere to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews) guidelines for reporting. Peer-reviewed articles will be searched in databases like Ovid MEDLINE, OVID Embase, PEDro, OVID PsycINFO, EBSCO CINAHL, the Cochrane Library, Scopus, IEEE Xplore, Web of Science, and Global Index Medicus. The research team will create a data extraction form covering study characteristics, participant characteristics, underlying models and frameworks, research findings, implications for technology coadaptation, and any identified study limitations. A directed content analysis approach will be used, incorporating the Selection, Optimization, and Compensation framework and Sex- and Gender-Based Analysis Plus theoretical framework.

Results
The results of this study are expected in January 2024.

Conclusions
This scoping review endeavors to present a thorough overview of the available evidence concerning how smart technologies interact with older adults over an extended period. The insights gained from this review will lay the groundwork for a research program that explores how older adults adapt to and use smart technologies throughout their lives, ultimately leading to improved user satisfaction and experience and facilitating aging in place with tailored support and user-centered design principles.

International Registered Report Identifier (IRRID)
PRR1-10.2196/51129
ANALISIS YURIDIS TERHADAP PROGRAM PEMBANGUNAN FOOD ESTATE DI KAWASAN HUTAN DITINJAU DARI ECO-JUSTICE
Authors: Rizkia Diffa Yuliantika  , Imamulhadi Imamulhadi , Supraba Sekarwati  
Published: October 2023

ABSTRAK
Pada tahun 2020 Presiden Joko Widodo mengemukakan wacana pembangunan food estate sebagai respon atas peringatan krisis di masa pandemi Covid-19. Maka dari itu untuk memenuhi kebutuhan pangan dalam negeri, pemerintah menerbitkan Peraturan Menteri LHK No.24/2020 melalui Kementerian Lingkungan Hidup dan Kehutanan tentang Penyediaan Kawasan Hutan untuk Pembangunan Food Estate, yang kemudian peraturan tersebut dicabut dan digantikan dengan PermenLHK No. 7 Tahun 2021. Hasil penelitian menunjukkan bahwa kebijakan pembangunan food estate di kawasan hutan memiliki banyak problematika, yaitu bertentangan dengan peraturan yang lebih tinggi serta masalah dalam pengimplementasiannya. PermenLHK tersebut juga bertentangan dengan nilai-nilai keadilan ekologi di mana seharusnya manusia hidup berdampingan dengan harmonis bersama alam.
Kata kunci: Kebijakan, Keadilan Ekologi, Lumbung Pangan, Penggunaan Lahan.
ABSTRACT
In 2020 President Joko Widodo announced a discourse on food estates as a response to the crisis warning during the Covid-19 pandemic. Therefore, to meet domestic food needs, the government issued Minister of Environment and Forestry Regulation No. 24/2020 through the Ministry of Environment and Forestry concerning Provision of Forest Areas for Food Estate Development, which was later revoked and replaced by PermenLHK No. 7 of 2021. The results show that the food estate development policy in forest areas has many problems, namely contrary to higher regulations and problems in its implementation. The PermenLHK also contradicts the values of ecological justice where humans should live side by side in harmony with nature.
Keywords: Ecological Justice, Food Estate, Land Use, Policy.
UPAYA PENEGAKAN HUKUM DAN PERLINDUNGAN KORBAN TINDAK PIDANA LINGKUNGAN HIDUP DITINJAU DARI SUDUT PANDANG GREEN VICTIMOLOGY
Authors: Annisa Mutiara  
Published: October 2023

ABSTRAK
Dalam perkembangannya, tindak pidana kini tidak hanya berorientasi pada permasalahan yang berkaitan dengan kemanusiaan saja, melainkan juga pada masalah lingkungan hidup. Tindak pidana lingkungan hidup sendiri sudah marak terjadi di Indonesia, beriringan dengan itu, maka banyak pula yang menjadi korbannya, seperti misalnya pada kasus bocornya minyak di Perairan Balikpapan yang mengakibatkan hutan mangrove rusak (Putusan MA Nomor 88/PID-LH/2019/PT.SMR). Penegakan hukum atau perlindungan yang diberikan pada tindak pidana lingkungan hidup di Indonesia sendiri kini masih kurang dalam pengimplementasiannya, dimana seringkali sipil ataupun petinggi negara lainnya menganggap remeh perlindungan korban tindak pidana lingkungan hidup. Maka dari itu, adapun pembahasan pada tulisan ini adalah berkaitan dengan bagaimana upaya penegakan hukum pada kasus tindak pidana lingkungan hidup yang terjadi di Indonesia, beserta dengan upaya perlindungan hukum yang diberikan oleh negara pada korban tindak pidana lingkungan hidup dalam perspektif green victimology sebagai proses sosial dan respon institusional yang berkaitan dengan korban kejahatan lingkungan, dengan juga merujuk pada UU No. 32 Tahun 2009 tentang Perlindungan dan Pengelolaan Lingkungan Hidup.
Kata kunci: Green Victimology; Penegakan Hukum; Perlindungan Korban; Tindak Pidana Lingkungan Hidup.
ABSTRACT
In its development, criminal acts are now not only oriented to problems related to humanity, but also to environmental issues. Environmental crimes themselves have been rife in Indonesia, along with that, so many are also victims, such as in the case of oil leaks in Balikpapan Waters which resulted in damaged mangrove forests (MA Decision Number 88 / PID-LH / 2019 / PT. SMR). Law enforcement or protection given to environmental crimes in Indonesia itself is still lacking in its implementation, where often civilians or other state officials underestimate the protection of victims of environmental crimes. Therefore, the discussion in this paper is related to how law enforcement efforts in environmental crime cases that occur in Indonesia, along with legal protection efforts provided by the state to victims of environmental crimes in the perspective of green victimology as a social process and institutional response related to victims of environmental crimes, by also referring to Law No. 32 of 2009 concerning Environmental Protection and Management.
Keywords: Environmental Crimes; Green Victimology; Law Enforcement; Victim Protection.
UPAYA PENYELESAIAN KONFLIK LAHAN GARAPAN MASYARAKAT KABUPATEN BERAU DIATAS KAWASAN IPPKH PT BERAU COAL
Authors: D Lababan Muhamad Oscario , Kurniati Nia , Adharani Yulinda 
Published: October 2023

ABSTRAK
Konflik Lahan dan Sengketa Tanah menjadi salah satu permasalahan Hukum Agraria yang cukup rumit dan berkepanjangan. Konflik lahan yang terjadi karena ada dua subjek hukum yang mempunyai kepentingan yang berbeda dalam satu lahan yang sama menjadikan permasalahan Agraria ini menjadi suatu permasalahan yang terus terjadi sampai sekarang. Konflik Lahan di Kawasan Hutan yang terjadi di Kabupaten Berau antara PT Berau Coal Sebagai Pemegang Izin Pinjam Pakai Kawasan Hutan (IPPKH) di Kawasan Hutan Negara di Desa Gurimbang dengan Masyarakat Penggarap yang menggarap Kawasan Hutan yang sama berbekal Surat Keterangan Garapan yang diterbitkan oleh Kepala Kampung/Kepala Desa Gurimbang untuk dijadikan tanah garapan. Hal tersebut menimbulkan konflik diantara kedua belah pihak karena satu sama lain merasa berhak untuk memanfaatkan Kawasan Hutan Tersebut. Sehingga upaya penyelesaian konflik lahan ini harus dilakukan melalui jalur non-litigasi dengan skema Mediasi-Arbitrase dengan klausul perjanjian diantara kedua belah pihak yaitu ganti tanam tumbuh kepada Masyarakat Penggarap Desa Gurimbang oleh PT Berau Coal.
Kata kunci: Izin Kawasan; Non-Litigasi; Tanah Garapan.
ABSTRACT
Land Conflicts and Land Disputes are one of the problems of Agrarian Law that is quite complicated and prolonged. Land conflicts that occur because there are two legal subjects who have different interests in the same land make this Agrarian problem a problem that continues to occur until now. Land Conflict in Forest Area that occurred in Berau regency between PT Berau Coal as the Holder of a Forest Area Loan and Use Permit (IPPKH) in the State Forest Area in Gurimbang Village and the Cultivator Community who worked on the same Forest Area armed with a Certificate of Cultivation issued by the Village Head/Head of Gurimbang Village to make Cultivator Land. This creates conflicts between the two sides because each other feels entitled to use the Forest Area. So that efforts to resolve this land conflict must be carried out through non-litigation channels with a Mediation-Arbitration scheme with an agreement clause between the two parties, namely the replacement of planting plants to the Gurimbang Village Cultivation Community by PT Berau Coal.
Keywords: Area Permit; Cultivator land; Non-Litigation.