bluuebunny/crossref_metadata_2025_split huggingface dataset:
An open dataset on individual perceptions of transport policies
Authors: Kieu Minh , Comber Alexis , Nguyen Thi Thuy Hang , Bui Quang Thanh , Hoang Huu Phe , Malleson Nick 
Published: January 2024

AbstractMany cities are facing challenges caused by the increasing use of motorised transport and Hanoi, Vietnam, is no exception. The proliferation of petrol powered motorbikes has caused serious problems of congestion, pollution, and road safety. This paper reports on a new survey dataset that was created as part of the Urban Transport Modelling for Sustainable Well-Being in Hanoi (UTM-Hanoi) project. The survey of nearly 30,000 respondents gathers data on households’ demographics, perceptions, opinions and stated behaviours. The data are informative in their own right and have also been used to experiment with multi-scale spatial statistics, synthetic population generation and machine learning approaches to predicting an individual’s perceptions of potential government policies. The paper reports on the key findings from the survey and conducts a technical validation to contrast the outcomes to similar datasets that are available.
A multicellular brain spheroid model for studying the mechanisms and bioeffects of ultrasound-enhanced drug penetration beyond the blood‒brain barrier
Authors: Paranjape Anurag N. , D’Aiuto Leonardo , Zheng Wenxiao , Chen Xucai , Villanueva Flordeliza S. 
Published: January 2024

AbstractThe blood‒brain barrier (BBB) acts as a hindrance to drug therapy reaching the brain. With an increasing incidence of neurovascular diseases and brain cancer metastases, there is a need for an ideal in vitro model to develop novel methodologies for enhancing drug delivery to the brain. Here, we established a multicellular human brain spheroid model that mimics the BBB both architecturally and functionally. Within the spheroids, endothelial cells and pericytes localized to the periphery, while neurons, astrocytes, and microglia were distributed throughout. Ultrasound-targeted microbubble cavitation (UTMC) is a novel noninvasive technology for enhancing endothelial drug permeability. We utilized our three-dimensional (3D) model to study the feasibility and mechanisms regulating UTMC-induced hyperpermeability. UTMC caused a significant increase in the penetration of 10 kDa Texas red dextran (TRD) into the spheroids, 100 µm beyond the BBB, without compromising cell viability. This hyperpermeability was dependent on UTMC-induced calcium (Ca2+) influx and endothelial nitric oxide synthase (eNOS) activation. Our 3D brain spheroid model, with its intact and functional BBB, offers a valuable platform for studying the bioeffects of UTMC, including effects occurring spatially distant from the endothelial barrier.
Investigating school absenteeism and refusal among Australian children and adolescents using Apriori association rule mining
Authors: Haque Umme Marzia , Kabir Enamul , Khanam Rasheda 
Published: January 2024

AbstractIdentifying and determining the multitude of reasons behind school absences of students is often challenging. This study aims to uncover the hidden reasons for school absence in children and adolescents. The analysis is conducted on a national survey that includes 2967 Australian children and adolescents aged 11–17. The Apriori association rule generator of machine learning techniques and binary logistic regression are used to identify the significant predictors of school absences. Out of 2484, 83.7% (n = 2079) aged (11–17) years children and adolescents have missed school for various reasons, 42.28% (n = 879) are (11–15) years old, 24.52% (n = 609) and 16.9% (n = 420) are 16- and 17-years old adolescents respectively. A considerable proportion of adolescents, specifically 16.4% (n = 407) and 23.4% (n = 486) of 16 and 17 years old, respectively, have selected ‘refused to say’ as their reason for not attending school. It also highlights the negative outcomes associated with undisclosed reasons for school absence, such as bullying, excessive internet/gaming, reduced family involvement, suicide attempts, and existential hopelessness. The findings of the national survey underscore the importance of addressing these undisclosed reasons for school absence to improve the overall well-being and educational outcomes of children and adolescents.
Sexual dimorphism in NLR transcripts and its downstream signaling protein IL-1ꞵ in teleost Channa punctata (Bloch, 1793)
Authors: Chuphal Bhawna , Sathoria Priyanka , Rai Umesh , Roy Brototi 
Published: January 2024

AbstractNucleotide-binding oligomerization domain-like receptors (NOD-like receptors or NLRs) are a family of intracellular pattern recognition receptors (PRRs) that initiates as well as regulate inflammatory responses. NLRs are characterized by a centrally located nucleotide binding domain and a leucine rich repeat domain at the C-terminal responsible for the recognition of intracellular microbe-associated molecular patterns (MAMPs) and danger-associated molecular patterns (DAMPs). In the present study in adult spotted snakehead we have investigated the sex-dependent tissue distribution of NLRs known to be associated with inflammation in teleost namely NOD1, NOD2, NLRC3, NLRC5, and NLRX1. Further, the sexual dimorphism in the expression of NLR transcript as well as the pro-inflammatory protein IL-1β was explored in fish under normal conditions, and in fish exposed to bacterial lipopolysaccharide (LPS). The NLRs show ubiquitous and constitutive expression in all the tissues. Moreover, a prominent disparity between males and females was observed in the basal expression of these genes in various tissues. The sexual dimorphism in NLR expression was also prominent when fish were exposed to LPS. Similarly, IL-1β exhibited sexual dimorphism in both normal as well as LPS-exposed fish.
Bipolar disorder and the risk of cardiometabolic diseases, heart failure, and all-cause mortality: a population-based matched cohort study in South Korea
Authors: Lee You-Bin , Kim Hyewon , Lee Jungkuk , Kang Dongwoo , Kim Gyuri , Jin Sang-Man , Kim Jae Hyeon , Jeon Hong Jin , Hur Kyu Yeon 
Published: January 2024

AbstractThe association of bipolar disorder (BD) with the risk of cardiometabolic diseases and premature death in Asians needs to be further determined. Relatively less attention has been paid to heart failure (HF) among cardiometabolic outcomes. We analyzed the Korean National Health Insurance Service database (2002–2018) for this population-based, matched cohort study. The hazards of ischemic stroke, ischemic heart disease (IHD), hospitalization for HF (hHF), composite cardiometabolic diseases, and all-cause mortality during follow-up were compared between individuals with BD (n = 11,329) and 1:1-matched controls without psychiatric disorders among adults without cardiometabolic disease before or within 3 months of baseline. Hazards of outcomes were higher in individuals with BD than in matched controls (adjusted hazard ratios [95% confidence intervals]: 1.971 [1.414–2.746] for ischemic stroke, 1.553 [1.401–1.721] for IHD, 2.526 [1.788–3.567] for hHF, 1.939 [1.860–2.022] for composite cardiometabolic diseases, and 2.175 [1.875–2.523] for all-cause mortality) during follow-up. Associations between BD and outcome hazards were more prominent in younger individuals (p for interaction < 0.02, except for ischemic stroke) and women (p for interaction < 0.04, except for hHF). Screening and preventive measures for cardiometabolic deterioration and early mortality may need to be intensified in individuals with BD, even in young adults, especially women.
Subtle variation in sepsis-III definitions markedly influences predictive performance within and across methods
Authors: Cohen Samuel N. , Foster James , Foster Peter , Lou Hang , Lyons Terry , Morley Sam , Morrill James , Ni Hao , Palmer Edward , Wang Bo , Wu Yue , Yang Lingyi , Yang Weixin 
Published: January 2024

AbstractEarly detection of sepsis is key to ensure timely clinical intervention. Since very few end-to-end pipelines are publicly available, fair comparisons between methodologies are difficult if not impossible. Progress is further limited by discrepancies in the reconstruction of sepsis onset time. This retrospective cohort study highlights the variation in performance of predictive models under three subtly different interpretations of sepsis onset from the sepsis-III definition and compares this against inter-model differences. The models are chosen to cover tree-based, deep learning, and survival analysis methods. Using the MIMIC-III database, between 867 and 2178 intensive care unit admissions with sepsis were identified, depending on the onset definition. We show that model performance can be more sensitive to differences in the definition of sepsis onset than to the model itself. Given a fixed sepsis definition, the best performing method had a gain of 1–5% in the area under the receiver operating characteristic (AUROC). However, the choice of onset time can cause a greater effect, with variation of 0–6% in AUROC. We illustrate that misleading conclusions can be drawn if models are compared without consideration of the sepsis definition used which emphasizes the need for a standardized definition for sepsis onset.
Tuning the superconducting performance of YBa2Cu3O7−δ films through field-induced oxygen doping
Authors: Alcalà Jordi , Fernández-Rodríguez Alejandro , Günkel Thomas , Barrera Aleix , Cabero Mariona , Gazquez Jaume , Balcells Lluis , Mestres Narcís , Palau Anna 
Published: January 2024

AbstractThe exploration of metal–insulator transitions to produce field-induced reversible resistive switching effects has been a longstanding pursuit in materials science. Although the resistive switching effect in strongly correlated oxides is often associated with the creation or annihilation of oxygen vacancies, the underlying mechanisms behind this phenomenon are complex and, in many cases, still not clear. This study focuses on the analysis of the superconducting performance of cuprate YBa2Cu3O7−δ (YBCO) devices switched to different resistive states through gate voltage pulses. The goal is to evaluate the effect of field-induced oxygen diffusion on the magnetic field and angular dependence of the critical current density and identify the role of induced defects in the switching performance. Transition electron microscopy measurements indicate that field-induced transition to high resistance states occurs through the generation of YBa2Cu4O7 (Y124) intergrowths with a large amount of oxygen vacancies, in agreement with the obtained critical current density dependences. These results have significant implications for better understanding the mechanisms of field-induced oxygen doping in cuprate superconductors and their role on the superconducting performance.
Bifunctional of Fe3O4@chitosan nanocomposite as a clarifying agent and cationic flocculant on different sugar solutions as a comprehensive semi industrial application
Authors: Dardeer Hemat M. , Ibrahim Ahmed S. , Gad Ahmed N. , Gaber Abdel-Aal M. 
Published: January 2024

AbstractIn the sugar industry, eliminating side impurities throughout the manufacturing process is the most significant obstacle to clarifying sugar solutions. Herein, magnetic chitosan (MCS) nanocomposite was Fabricated to be used as a biodegradable, environmentally friendly clarifying agent throughout the cane juice and sugar refining processes. Fe3O4 was synthesized using the coprecipitation procedure, and then MCS was combined using a cross-linking agent. Furthermore, 14.76 emu g−1 was the maximum saturation magnetization (Ms) value. Because MCS is magnetically saturated, it may be possible to employ an external magnetic field to separate the contaminant deposited on its surface. Additionally, zeta potential analysis showed outstanding findings for MCS with a maximum value of (+) 20.7 mV, with improvement in color removal % up to 44.8% using MCS with more than 24% in color removal % compared to the traditional clarification process. Moreover, utilizing MCS reduced turbidity from 167 to 1 IU. Overall, we determined that MCS nanocomposite exhibits considerable effectiveness in the clarifying process for different sugar solutions, performing as an eco-friendly bio-sorbent and flocculating material.
Exploratory study of cold hypersensitivity in Japanese women: genetic associations and somatic symptom burden
Authors: Wu Xuefeng , Yoshino Tetsuhiro , Maeda-Minami Ayako , Ishida Sachiko , Tanaka Masami , Nishi Akinori , Tahara Yoshio , Inami Ryohei , Sugiyama Aiko , Horiba Yuko , Watanabe Kenji , Mimura Masaru 
Published: January 2024

AbstractTemperature perception is essential for humans to discern the environment and maintain homeostasis. However, some individuals experience cold hypersensitivity, characterized by a subjective feeling of coldness despite ambient environmental temperatures being normal, the underlying mechanisms of which are unknown. In this study, we aimed to investigate the relationship between subjective cold symptoms and somatic burden or single nucleotide polymorphisms to understand the causes of cold hypersensitivity. We conducted an online questionnaire survey [comprising 30 questions, including past medical history, subjective symptoms of cold hypersensitivity, and the Somatic Symptom Scale-8 (SSS-8)]. Respondents were 1200 Japanese adult female volunteers (age: 20–59 years), recruited between April 21 and May 25, 2022, who were customers of MYCODE, a personal genome service in Japan. Among the 1111 participants, 599 (54%) reported cold hypersensitivity. Higher cold hypersensitivity severity was positively associated with the SSS-8 scores. Additionally, a genome-wide association study for cold hypersensitivity was conducted using array-based genomic data obtained from genetic testing. We identified 11 lead variants showing suggestive associations (P < 1 × 10–5) with cold hypersensitivity, some of which showed a reasonable change in expression in specific tissues in the Genotype-Tissue Expression database. The study findings shed light on the underlying causes of cold hypersensitivity.
Fluid chemistry alters faunal trophodynamics but not composition on the deep-sea Capelinhos hydrothermal edifice (Lucky Strike vent field, Mid-Atlantic Ridge)
Authors: Alfaro-Lucas Joan M. , Martin Daniel , Michel Loïc N. , Laes Agathe , Cathalot Cécile , Fuchs Sandra , Sarrazin Jozée 
Published: January 2024

AbstractThe recently discovered deep-sea Capelinhos hydrothermal edifice, ~ 1.5 km of the main Lucky Strike (LS) vent field (northern Mid-Atlantic Ridge), contrasts with the other LS edifices in having poorly-altered end-member hydrothermal fluids with low pH and chlorine, and high metal concentrations. Capelinhos unique chemistry and location offer the opportunity to test the effects of local abiotic filters on faunal community structure while avoiding the often-correlated influence of dispersal limitation and depth. In this paper, we characterize for the first time the distribution patterns of the Capelinhos faunal communities, and analyze the benthic invertebrates (> 250 µm) inhabiting diffusive-flow areas and their trophic structures (δ13C, δ15N and δ34S). We hypothesized that faunal communities would differ from those of the nearest LS vent edifices, showing an impoverished species subset due to the potential toxicity of the chemical environment. Conversely, our results show that: (1) community distribution resembles that of other LS edifices, with assemblages visually dominated by shrimps (close to high-temperature focused-fluid areas) and mussels (at low-temperature diffuse flow areas); (2) most species from diffuse flow areas are well-known LS inhabitants, including the bed-forming and chemosymbiotic mussel Bathymodiolus azoricus and (3) communities are as diverse as those of the most diverse LS edifices. On the contrary, stable isotopes suggest different trophodynamics at Capelinhos. The high δ15N and, especially, δ13C and δ34S values suggest an important role of methane oxidation (i.e., methanotrophy), rather than the sulfide oxidation (i.e., thiotrophy) that predominates at most LS edifices. Our results indicate that Capelinhos shows unique environmental conditions, trophic structure and trophodynamics, yet similar fauna, compared to other LS edifices, which suggest a great environmental and trophic plasticity of the vent faunal communities at the LS.
Measurements of cadmium levels in relation to tobacco dependence and as a function of cytisine administration
Authors: Wróblewski Karol , Wojnicka Julia , Tutka Piotr , Szmagara Agnieszka , Błażewicz Anna 
Published: January 2024

AbstractCigarette smoking delivers a number of heavy metals, including cadmium (Cd), into the body. Bioaccumulation may result in an increase in pathological consequences over time. The assessment of changes in serum Cd concentrations during the treatment of cigarette dependence with cytisine was performed for the first time. Parameters assessing smoking habits, strength of addiction, and effectiveness of therapy were analyzed. Cd was determined before, during, and after the end of treatment. The serum Cd levels were significantly higher in the smokers than in the nonsmokers. Significant differences in Cd concentrations between sampling times in smokers were observed. Individuals who stopped smoking had significantly lower Cd concentrations compared to baseline. A significant positive correlation between the serum Cd before treatment and smoking urges was also obtained. Additionally, salivary Cd determinations were performed before treatment to evaluate the use of this method to assess cigarette addiction. Our findings indicate that Cd can be used as a biomarker of smoking addiction, and provide an alternative assessment of tobacco smoke exposure to other methods. The results provide new knowledge related to Cd concentrations in human body fluids and may play a role in monitoring and assessing the efficacy of cytisine for smoking cessation.
Exact solutions of the (3+1)-generalized fractional nonlinear wave equation with gas bubbles
Authors: Seadawy Aly R. , Ali Asghar , Altalbe Ali , Bekir Ahmet 
Published: January 2024

AbstractIn this manuscript, we implement the travelling wave solutions of the fractional (3+1) generalized computational nonlinear wave equation with gas bubbles via application of five mathematical methods. Liquids with gas bubbles primarily arise in various applications like science, engineering, and mathematical physics. The obtained solitary waves solutions have fruitful applications in engineering, science, life, nature and physics. Several novel soliton solutions of concerned model are established in the form of hyperbolic, trigonometric, exponential and rational functions. To handle all calculations and verification of obtained results, computational software Mathematica 12.1 is used. For the demonstration of the physical behaviour of concern model, some solutions are plotted graphical in 2-dimensional and 3-dimensional by imparting specific values to the parameters under constrain conditions. Finally, we intrigue both two and three dimensional to explain the physical behavior of the model.
Trichoderma afroharzianum TRI07 metabolites inhibit Alternaria alternata growth and induce tomato defense-related enzymes
Authors: Philip Bassant , Behiry Said I. , Salem Mohamed Z. M. , Amer Mostafa A. , El-Samra Ibrahim A. , Abdelkhalek Ahmed , Heflish Ahmed 
Published: January 2024

AbstractIdentifying a viable substitute for the limited array of current antifungal agents stands as a crucial objective in modern agriculture. Consequently, extensive worldwide research has been undertaken to unveil eco-friendly and effective agents capable of controlling pathogens resistant to the presently employed fungicides. This study explores the efficacy of Trichoderma isolates in combating tomato leaf spot disease, primarily caused by Alternaria alternata. The identified pathogen, A. alternata Alt3, was isolated and confirmed through the ITS region (OQ888806). Six Trichoderma isolates were assessed for their ability to inhibit Alt3 hyphal growth using dual culture, ethyl acetate extract, and volatile organic compounds (VOCs) techniques. The most promising biocontrol isolate was identified as T. afroharzianum isolate TRI07 based on three markers: ITS region (OQ820171), translation elongation factor alpha 1 gene (OR125580), and RNA polymerase II subunit gene (OR125581). The ethyl acetate extract of TRI07 isolate was subjected to GC–MS analysis, revealing spathulenol, triacetin, and aspartame as the main compounds, with percentages of 28.90, 14.03, and 12.97%, respectively. Analysis of TRI07-VOCs by solid-phase microextraction technique indicated that the most abundant compounds included ethanol, hydroperoxide, 1-methylhexyl, and 1-octen-3-one. When TRI07 interacted with Alt3, 34 compounds were identified, with major components including 1-octen-3-one, ethanol, and hexanedioic acid, bis(2-ethylhexyl) ester. In greenhouse experiment, the treatment of TRI07 48 h before inoculation with A. alternata (A3 treatment) resulted in a reduction in disease severity (16.66%) and incidence (44.44%). Furthermore, A3 treatment led to improved tomato growth performance parameters and increased chlorophyll content. After 21 days post-inoculation, A3 treatment was associated with increased production of antioxidant enzymes (CAT, POD, SOD, and PPO), while infected tomato plants exhibited elevated levels of oxidative stress markers MDA and H2O2. HPLC analysis of tomato leaf extracts from A3 treatment revealed higher levels of phenolic acids such as gallic, chlorogenic, caffeic, syringic, and coumaric acids, as well as flavonoid compounds including catechin, rutin, and vanillin. The novelty lies in bridging the gap between strain-specific attributes and practical application, enhancing the understanding of TRI07’s potential for integrated pest management. This study concludes that TRI07 isolate presents potential natural compounds with biological activity, effectively controlling tomato leaf spot disease and promoting tomato plant growth. The findings have practical implications for agriculture, suggesting a sustainable biocontrol strategy that can enhance crop resilience and contribute to integrated pest management practices.
The temporal progression of retinal degeneration and early-stage idebenone treatment in the Pde6brd1/rd1 mouse model of retinal dystrophy
Authors: Zhang Lei , Liu Wei , Wang Hai-Yan , Qiang Wei , Wang Ru , Cui Zhi-Li , Zhang Zuo-Ming 
Published: January 2024

AbstractPhotoreceptor cell death, primarily through apoptosis, related to retinal disorders like retinitis pigmentosa (RP), would result in vision loss. The pathological processes and crucial mutant conditions preceding photoreceptor cell demise are not well understood. This study aims to conduct an in-depth examination of early-stage changes in the widely utilized Pde6brd1/rd1 (rd1) mouse model, which has Pde6b gene mutations representing autosomal recessive RP disorder. We investigated the morphology and ultrastructure of retinal cells, including second-order neurons, during the initial phase of disease progression. Our findings revealed that mitochondrial alterations in rod photoreceptors were present as a predeath mutant state as early as postnatal day 3 (P3). The bipolar and horizontal cells from the rd1 mouse retina exhibited significant morphological changes in response to loss of photoreceptor cells, indicating that second-order neurons rely on these cells for their structures. Subsequent oral administration of idebenone, a mitochondria-protective agent, enhanced retinal function and promoted both photoreceptor cell survival and inner retinal second-order synaptogenesis in rd1 mice at P14. Our findings offer a mechanistic framework, suggesting that mitochondrial damage acts as an early driver for photoreceptor cell death in retinal degeneration.