bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of difference in height of automated irrigation system and height of kidney on intrarenal pressure in an in vitro kidney model
Authors: Taguchi Makoto , Kinoshita Hidefumi 
Published: October 2023

Abstract
Purpose: To clarify the impact of the difference in height between an automated irrigation system and the renal pelvis using an artificial kidney model.
Methods: A flexible ureteroscope was placed into an artificial kidney model centrally through the ureteral access sheath, and the pressure in the model was measured as the intrarenal pressure (IRP). Three types of irrigation systems were used in this study: a pressure-controlled system, a gravity-based irrigation system, and an infusion pump. During measurements, either the working channel of the flexible ureteroscope was unoccupied or various instruments (200-μm laser fiber and 1.5-Fr retrieval basket) were inserted into the working channel. The three irrigation systems were evaluated under three conditions: at the same height as the artificial kidney model, 50 cm higher than the model, and 50 cm lower than the model. The maximum IRP was measured and compared.
Results: The IRP was affected by the height difference between the pressure-controlled system and the artificial kidney model in all conditions (p < 0.05). Additionally, the IRP was affected by the height difference between the gravity-based irrigation system and the artificial kidney model in all conditions (50 cm taller vs. same height, p < 0.05; 50 cm taller vs. 50 cm lower, p < 0.05). However, the IRP was not affected by the height difference between the infusion pump and the artificial kidney model in all conditions.
Conclusion: Clinicians should check whether there is a difference between the height of the kidney and the height of the pressure-controlled system.
Interferon-Induced Monocyte Immune Response Augments Immunotherapy and Correlates with Clinical Outcomes in Breast Cancer
Authors: Zhong Xugang , Liu Haitao , Gong Chuxiong , Yin Li , Fan Yong , He Zeju , Hong Zheping , Tong Yu , Meng Xiang , Li Yanlei , Li Yuewen , Kang Yao , Bi Qing 
Published: October 2023

Abstract
In this study, we established comprehensive single-cell transcriptomic profiles of myeloid cells and T cells in breast cancer and identified a group of monocytes that secrete various chemokines to promote anti-tumor immunity and respond to interferon-gamma (IFN-γ), as well as a group of T cells that self-secrete IFN-γ. Notably, these T cells not only serve as targets of IFN-γ but can also produce IFN-γ themselves. We observed a strong positive feedback loop between these unique monocytes and T cells. The monocytes secrete various chemokines to recruit T cells into the tumor microenvironment. Additionally, they produce SPP1, stimulating DC cells to produce IL-12, which further promotes the production of IFN-γ by T cells. On the other hand, the IFN-γ secreted by T cells further activates monocytes. Furthermore, after immunotherapy, there was a significant increase in these unique monocytes in the tumor microenvironment, indicating that they could serve as biomarkers of immunotherapeutic response and possess the potential to activate anti-tumor immunity. Finally, survival analysis and immune fluorescence staining of patient samples support the correlation between the density of these unique monocytes and patient prognosis. These findings underscore the importance of monocytes and their interactions with T cells in breast cancer, providing insights into potential targets for immunotherapy and prognosis assessment.
The response of the Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819) exposed to copper-doped zinc nanoparticles
Authors: BOUZIDI Imen , AYARI-KLITI Rakia , BEYREM Hamouda , MOUGIN Karine , SELLAMI Badreddine 
Published: October 2023

Abstract
The aim of this study is to evaluate the exposure effects to copper-doped zinc oxide nanoparticles (Cu-ZnO NPs) on bivalves through physiological and biochemical multi- markers. To achieve this objective, the selected biological material is the bioindicator mussel Mytilus galloprovincialis used as sentinel of marine pollution.
The evaluation of the physiological response has been established by the filtration and respiration capacity of the mussel. That of biochemical response has been studied through biomarkers such as superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and acetylcholinesterase (AChE).
The estimation of the toxicity of Cu-ZnO NPs through physiological parameters showed that the impact depends on the considered chemical compound and on its concentration. In addition to the contaminant concentration effect, the oxidative stress and neurotoxicity parameters depend on the organ involved.
Overall, the use of an integrative approach combining the physiological and biochemical responses represents a good way to understand the relational profile between contaminants and marine organisms that could be part of biomonitoring programs of coastal ecosystems.
Hinglish HateBERT: Hate Speech Classification in Hinglish language
Authors: singh Nikhil , Mundra Shikha 
Published: October 2023

Abstract
Hate speech has become a widespread concern in the contemporary world, surpassing geographical confines and impacting communities on a worldwide level. The role of digital platforms in disseminating hate speech, the obstacles in regulating online hate speech, and the additional complexity due to language diversity collectively demand a comprehensive method to detect and identify hate speech from free speech. In this work, we introduce Hinglish HateBERT, a pre-trained BERT model for Hate speech detection in code-mixed Hindi English language. The model was trained on a large-scale dataset having offensive and non-offensive content to avoid any bias. We finetuned Hinglish HateBERT using CNN and LSTM and performed experimentation on three publicly available dataset. Further, we presented a detailed comparative performance of our model with publicly available pretrained models for classifying hate speech in Hinglish. We observed that our proposed model Hinglish HateBERT significantly outperformed for two datasets. Also, we have released our model and code for research purpose at : Author can release it on request of reviewer or after revision.
Optimal Sizing and Power Losses Reduction of Photovoltaic Systems using PSO and LCL Filters
Authors: Péné Armel Duvalier , Boussaibo André , Tsegaing Fabrice , Tchouli Alain Foutche , Kitmo . , Barro Fabé Idrissa 
Published: October 2023

Abstract
The integration of renewable energy systems into electricity grids is a solution for strengthening electricity distribution networks (SEDNs). Renewable energies such as solar photovoltaics are suitable for reinforcing a low-voltage line by offering an electrical energy storage system. However, the integration of photovoltaic systems can lead to problems of harmonic distortion due to the presence of direct current or non-linear feedback in networks from other sources. Therefore, connection standards exist to ensure the quality of the energy before injection at a point of common coupling (PCC). In this work, particle swarm optimization (PSO) is used to control a boost converter and to evaluate the power losses and the harmonic distortion rate. The test on the IEEE 14 bus standard makes it possible to determine the allocation or integration nodes for other sources such as biomass, wind or hydrogen generators, in order to limit the impact of harmonic disturbances (LIHs). The evaluation of the harmonic distortion rate, the power losses as well as the determination of the system size is done using an objective function defined based on the integration and optimization constraints of the system. The proposed model performs better since the grid current and voltage are stabilized in phase after the photovoltaic source is injected.
Trait Impulsivity Influences Behavioural and Physiological Responses to Threat in a Virtual Environment
Authors: Baker Christopher , Fairclough Stephen , Ogden Ruth , Barnes Rachel , Tootill Jessica 
Published: October 2023

Abstract

Trait impulsivity represents a tendency to take action without forethought or consideration of consequences. This trait is multifaceted and can be decomposed into attentional, motor and non-planning subtypes of impulsivity. The purpose of the current study was to investigate how subtypes of trait impulsivity responded to different degrees of threat within room-scale virtual reality (VR) with respect to behaviour and level of physiological activation. Thirty-four participants were required to negotiate a virtual environment (VE) where they walked at height with the continuous threat of a virtual ‘fall.’ Behavioural measures related to the speed of movement, interaction frequency and risk were collected. Participants also wore ambulatory sensors to collect data from electrocardiogram (ECG) and electrodermal activity (EDA). Our results indicated that participants who scored highly on non-planning impulsivity exhibited riskier behaviour and higher skin conductance level (SCL). Participants with higher motor impulsivity interacted with more objects in the VE when threat was high, they also exhibited contradictory indicators of physiological activation. Attentional impulsivity was associated with a greater number of falls across the VE. The results demonstrate that subtypes of trait impulsivity respond to threats via different patterns of behaviour and levels of physiological activation, reinforcing the multifaceted nature of the trait.
Work-related Musculoskeletal Disorders among United Arab Emirates Schoolteachers: An Examination of Physical Activity
Authors: Zohair Hind Mahmoud , Girish Srilatha , Hazari Animesh 
Published: October 2023

Abstract

Objective:To estimate the prevalence of work-related musculoskeletal disorders and their association with physical activity among schoolteachers in the United Arab Emirates.Methods: This observational cross-sectional study involved 209 schoolteachers (aged 20-60) with a minimum of two years of experience. Data, including demographics (gender, age), Nordic Musculoskeletal Questionnaire (NMQ) for WMSD prevalence and pain sites, and Global Physical Activity Questionnaire (GPAQ) for physical activity levels, were collected. Six schools were visited for data collection, with consent from school heads and participants. Schedules were tailored to participant availability, allowing up to three attempts for participation. Non-respondents were identified after three unsuccessful attempts.Results:This study identified a high prevalence (71.4%) of work-related musculoskeletal disorders (WMSD) in UAE schoolteachers, with neck pain being the most common (74.3%). Major risk factors included age, workload, and low physical activity. A weak positive correlation (correlation coefficient: 0.042) between WMSD and physical activity was observed, indicating that factors beyond physical activity influence WMSD prevalence in this cohort.Conclusion:Findings suggest the need to promote physical activity and reduce workload for teachers, considering their age and gender. Additionally, there is a need to raise awareness regarding ergonomics and the importance of taking short breaks for stretching or physical movement to enhance the overall well-being of schoolteachers in the UAE and similar contexts. Diverse prevalence rates across different body areas underscore the necessity for individualized treatments.
The nursing application of multifunctional protective pants after posterior urethral stricture surgery: A randomized clinical trial
Authors: Chang Lu , Fang wenzhuo , Chen Bin , Cao Shilei , Fu Qiang , Zhang Kaile 
Published: October 2023

Abstract
Objective Posterior urethral stricture is a severe disease in urology, and end-to-end urethral anastomosis remains the gold standard treatment. The surgical outcome not only depends on meticulous intraoperative management but also on postoperative care. Key aspects of postoperative care include stable compression bandaging, prevention of skin tension and allergic blistering, and preventing penile from erection. We have produced a multifunctional protective pant that is expected to prove its effectiveness through a randomized controlled study.Methods This study included 50 patients who were divided into an experimental group and a control group. The patients in the experimental group wore the protective pants immediately after surgery. On the basis of routine care in the control group, health education and guidance for patients and family members on wearing protective pants were added. During the postoperative period until discharge, we observed the occurrence of wound bleeding, abnormal body temperature, and evaluated patient infection status based on results such as blood routine and procalcitonin. A numerical scoring table was used for pain assessment during the three days and nine shifts handover of patients. Patient feedback during pants usage was obtained through a self-assessment questionnaire two months after surgery.Results On the second day after surgery, the incidence of penile hematoma in the experimental group was significantly lower than that in the control group, with a statistically significant difference (P < 0.05). Within five days after surgery, the experimental group had a significantly lower incidence of wound bleeding, Scrotum edema, Skin allergic blisters and erectile pain compared to the control group, with a statistically significant difference (P < 0.05).Conclusion The use of the protective pants effectively reduced postoperative complications during the perioperative period, and significantly improving surgical success rates and patient satisfaction.
Vehicle video stabilization algorithm based on grid motion statistics and adaptive kalman filtering
Authors: Li Chengcheng , Tian Yuan , Ma Lisen , Jia yunhong , bi yuqi 
Published: October 2023

Abstract
Owing to the impact of vibration on the carrier of a car-mounted camera, video images are shaking, resulting in decreased or failed recognition accuracy based on visual-target detection. To solve this problem, a video stabilization algorithm based on grid motion statistics and an adaptive Kalman filter is proposed. To satisfy the real-time and precision requirements of the vehicle video stabilization algorithm, the Oriented Fast and Rotated Brief (ORB) feature point detection algorithm was selected to detect and describe the obtained video frames. In addition, the accuracy of the motion estimate is increased by deleting the erroneous match points using an erroneous match-removal algorithm based on grid motion statistics (GMS). The matching accuracy of the GMS-based feature matching algorithm increased by 2.3% and 4.1% compared to conventional feature-matching algorithms based on scale-invariant feature transform (SIFT) and ORB, respectively. However, the matching time between adjacent video frames was reduced by 76% and 16%, respectively. Considering the possible jitter of the vehicle-mounted camera, an adaptive Kalman filtering algorithm was used to smooth the acquired motion trajectory and solve the problem of classical Kalman filtering being sensitive to the initial value. The mean Peak Signal-to-Noise Ratio (PSNR) after stabilization rose by 10.27 dB in comparison to the video stability before stabilization. Therefore, this algorithm exhibits good stability.
Effect of non-glycosylated proteins from Melipona beecheii honey on the formation of Pseudomonas aeruginosa ATCC 27853 biofilm
Authors: Pool-Yam Luis , Ramón-Sierra Jesús , Oliva A. I. , Zamora-Bustillos Roberto , Ortiz-Vazquez Elizabeth 
Published: October 2023

Abstract
Pseudomonas aeruginosa is an opportunistic bacterium that can form a biofilm with the ability to colonize different surfaces, in addition to increasing resistance to antibiotics. An alternative to solve this problem may be the use of proteins from Melipona beecheii honey, which are capable of inhibiting the growth of this pathogen. The aim of this study is to evaluate the antibiofilm activity of the non-glycosylated protein fraction (F1) from M. beecheii. The crude protein extract (CPE) and F1 fraction inhibited P. aeruginosa biofilm growth above 80% at 4 and 1.3 µg/mL, respectively. These proteins affected the structure of the biofilm, as well as fleQ and fleR gene expressions involved in the formation and regulation of the P. aeruginosa biofilm. The results demonstrated that the F1 fraction proteins of M. beecheii honey inhibit and affect the formation of the P. aeruginosa biofilm.
Synergetic Effect of Essential oils and Calcium Phosphate Nanoparticles for Enhancement the Corrosion Resistance of Titanium Dental Implant
Authors: Zaher Heba Tark , Hefnawy Mahmoud A. , Medany Shymaa S. , Kamel S. M. , Fadlallah Sahar A. 
Published: October 2023

Abstract
Calcium phosphate (CaPO4) coating is one of various methods that is used to modify the topography and the chemistry of Ti dental implant surface to solve sever oral problems that result from diseases, accidents, or even caries due to its biocompatibility and ability to remineralization. In this work, anodized (Ti-bare) was coated by CaPO4 prepared from amorphous calcium phosphate nanoparticles (ACP-NPs) and confirmed the structure by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) techniques. Ti-bare was coated by prepared CaPO4 through the casting process, and the morphology of Ti/CaPO4 was characterized by scanning electron microscope (SEM) where the nano-flakes shape of CaPO4 and measured to be 60 ~ 80 nm was confirmed. The stability of Ti-bare and coated Ti/CaPO4 was studied in a simulated saliva solution using electrochemical impedance spectroscopy (EIS) and linear polarization techniques to deduce their corrosion resistance. Furthermore, three essential oils (EO), Cumin, Thyme, and Coriander, were used to stimulate their synergistic effect with the CaPO4 coat to enhance the corrosion resistance of Ti implant in an oral environment. The fitting EIS parameters based on Rs[RctC]W circuit proved that the charge transfer resistance (Rct) of Ti/CaPO4 increased by 264.4, 88.2, and 437.5% for Cumin, Thyme, and Coriander, respectively, at 2% concentration. Our new results confirmed that it is necessary to maintain the positive effect of the components of the oral environment and their ability to synergize with the material of the modified Ti surface to ensure the success of Ti implantation. Thus, the use of EO with coat Ti/CaPO4 proved great corrosion resistance value, which will enhance the remineralization process of the teeth.
Molecular characterization and expression of Cadherin-2 and Cadherin- 4 in Nile tilapia (Oreochromis niloticus) in response to Streptococcus agalactiae stimulus
Authors: Liang Xueying , Zheng Yusi , Zhang Zemiao , Peng Yinhui , Chen Honglin , Xu Peng , Wu Xinzhong , Cai Xiaohui 
Published: October 2023

Abstract
Cadherins are a molecular family that is essential for the Ca2+ dependent process of cell-cell adhesion. Moreover, Cadherins can also act as a receptor to mediate bacteria entrying into non-phagocytic cells. In the present study, members of the Cadherins family of cytokines, Cadherin 2 (OnCdh2) and Cadherin 4 (OnCdh4), were successfully cloned and characterized from the Nile tilapia Oreochromis niloticus. Their tissue distribution and expression patterns following bacterial were also investigated. The full-length cDNA sequences of OnCdh2 and OnCdh4 contained an open reading frame of 2721 and 2802 bp, encoding 906 and 933 amino acids with a theoretical isoelectric point of 4.74 and 4.73, respectively. Prediction of protein domains showed that OnCdh2 and OnCdh4 both consisted of one Cadherin prodomain super family, one Cadherin repeat-like domain, three Cadherin tandem repeat domain, one Cadherin domain, one Cadherin cytoplasmic region and a transmembrane domain. Homology comparisons indicated that OnCdh2 and OnCdh4 showed 94.10% and 99.25% identity to the Astatotilapia calliptera and a relative low identity of 75.63–75.97% and 70.35%-74.09% with its mammalian counterparts. Moreover, the residue 16 of cadherin repeat-like domain of OnCdh2 and OnCdh4 is Proline, which indicated that it may play a role in mediating bacterial invasion into intestinal epithelial cells. Phylogenetic tree analysis showed that OnCdh2 and OnCdh4 cluster together with other fish OnCdh2 and OnCdh4 molecules. The results of tissue distribution showed that OnCdh2 and OnCdh4 were both ubiquitous in all tissues examined of healthy tilapia with the highest level of expression in heart and brain, respectively. The expression level of OnCdh2 and OnCdh4 were rapidly activated at 1 h in brain, intestine and spleen after chanllenged by S. agalactiae. Taken together, the results indicated that OnCdh2 and OnCdh4 might be involved in the process of S. agalactiae invading into Nile tilapia and the immune reponse of Nile tilapia against bacterial infection.
Median nerve neuropathy resulting from blind removal attempts of etonogestrel contraceptive implant: A case report
Authors: Fungtammasan Siraphat , Sinthuchai Natchanika , Pataradool Kawee , Jaisamrarn Unnop , Santibenchakul Somsook 
Published: October 2023

Abstract
Nexplanon is an etonogestrel contraceptive implant that comes with an applicator, making it easier to insert and remove. Complications related to insertion and removal procedures, such as neural-vascular injuries, are rare. We describe a case of median nerve neuropathy resulting from blind removal attempts of an iatrogenically migrated implant. The patient presented with an unusual pain and an abnormal sensation in her left arm that worsened after blind attempts to remove the implant. Radiographs revealed that the rod was 3 cm from her insertion scar and deeply embedded in her left arm. The patient then underwent left arm exploration and implant removal under fluoroscopic guidance by an orthopedic surgeon. The rod was placed adjacent to the median nerve under the basilic vein. The symptoms gradually resolved after surgery. This indicates that patients with impalpable contraceptive implants should be referred for implant removal by specialists familiar with the procedure to prevent further deterioration of adjacent structures from iatrogenic implant migration.
Causality between Sarcopenia and Coronary Artery Disease: An updated Mendelian Randomization Study
Authors: Cao Li , Sheng Yang , He Yiting , Cai Chao , Wang Pei , Geng Zhirong , Liu Fuming 
Published: October 2023

Abstract
Background
There is evidence of a potential association between sarcopenia and coronary artery disease (CAD), but the causal relationship remains to be further determined.
Methods
We conducted a two-sample Mendelian randomization (MR) to evaluate the causal effect of sarcopenia, described as appendicular lean mass (ALM), walking pace (WP), and hand grip strength (HGS: right and left), on the risk of coronary heart disease (CHD) and myocardial infarction (MI). The inverse variance weighted (IVW) method was used as the main model, with auxiliary methods including weighted median (WM) and MR-Egger. A sensitivity analysis was conducted to evaluate the robustness. Risk factor analysis was performed to explore the potential pathway.
Results
IVW revealed that sarcopenia-related traits were causally associated with both CHD and MI. WM and MR-Egger further substantiated the causal associations. Sensitivity analysis showed no heterogeneity or pleiotropy was detected. Risk factor analysis showed that sarcopenia-related traits exerted effects on several traditional risk factors of CAD.
Conclusion
Sarcopenia might increase the risk of CHD and MI, which might imply that indexes for sarcopenia, like ALM, HGS, and WP, could be developed to screen specific populations with higher risk of CAD.
RETRACTED: Grain-sized moxibustion enhances anti-tumor immunity of tumor cell lysate vaccine
Authors: Shen Weiming , Hu Dan , Gong Chenyuan , Fang Cheng , Luo Jiaojiao , Wang Lixin , Yao Chao , Wu Huangan , Zhao Chen , Zhu Shiguo 
Published: October 2023

Abstract
The authors have requested that this preprint be removed from Research Square.