bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in the management of chronic kidney disease
Authors: Chen Teresa K , Hoenig Melanie P , Nitsch Dorothea , Grams Morgan E 
Published: December 2023

Abstract
Chronic kidney disease (CKD) represents a global public health crisis, but awareness by patients and providers is poor. Defined as persistent abnormalities in kidney structure or function for more than three months, manifested as either low glomerular filtration rate or presence of a marker of kidney damage such as albuminuria, CKD can be identified through readily available blood and urine tests. Early recognition of CKD is crucial for harnessing major advances in staging, prognosis, and treatment. This review discusses the evidence behind the general principles of CKD management, such as blood pressure and glucose control, renin-angiotensin-aldosterone system blockade, statin therapy, and dietary management. It additionally describes individualized approaches to treatment based on risk of kidney failure and cause of CKD. Finally, it reviews novel classes of kidney protective agents including sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, non-steroidal selective mineralocorticoid receptor antagonists, and endothelin receptor antagonists. Appropriate, widespread implementation of these highly effective therapies should improve the lives of people with CKD and decrease the worldwide incidence of kidney failure.
Adaptation of student behavioural routines during Covid-19: a multimodal approach
Authors: Girardini Nicolò Alessandro , Centellegher Simone , Passerini Andrea , Bison Ivano , Giunchiglia Fausto , Lepri Bruno 
Published: December 2023

AbstractOne population group that had to significantly adapt and change their behaviour during the COVID-19 pandemic is students. While previous studies have extensively investigated the impact of the pandemic on their psychological well-being and academic performance, limited attention has been given to their activity routines. In this work, we analyze students’ behavioural changes by examining qualitative and quantitative differences in their daily routines between two distinct periods (2018 and 2020). Using an Experience Sampling Method (ESM) that captures multimodal self-reported data on students’ activity, locations and sociality, we apply Non-Negative Matrix Factorization (NMF) to extract meaningful behavioural components, and quantify the variations in behaviour between students in 2018 and 2020. Surprisingly, despite the presence of COVID-19 restrictions, we find minimal changes in the activities performed by students, and the diversity of activities also remains largely unaffected. Leveraging the richness of the data at our disposal, we discover that activities adaptation to the pandemic primarily occurred in the location and sociality dimensions.
Multisource Holography
Authors: Kuo Grace , Schiffers Florian , Lanman Douglas , Cossairt Oliver , Matsuda Nathan 
Published: December 2023

Holographic displays promise several benefits including high quality 3D imagery, accurate accommodation cues, and compact form-factors. However, holography relies on coherent illumination which can create undesirable speckle noise in the final image. Although smooth phase holograms can be speckle-free, their non-uniform eyebox makes them impractical, and speckle mitigation with partially coherent sources also reduces resolution. Averaging sequential frames for speckle reduction requires high speed modulators and consumes temporal bandwidth that may be needed elsewhere in the system.
In this work, we propose multisource holography, a novel architecture that uses an array of sources to suppress speckle in a single frame without sacrificing resolution. By using two spatial light modulators, arranged sequentially, each source in the array can be controlled almost independently to create a version of the target content with different speckle. Speckle is then suppressed when the contributions from the multiple sources are averaged at the image plane. We introduce an algorithm to calculate multisource holograms, analyze the design space, and demonstrate up to a 10 dB increase in peak signal-to-noise ratio compared to an equivalent single source system. Finally, we validate the concept with a benchtop experimental prototype by producing both 2D images and focal stacks with natural defocus cues.
Progressive Shell Qasistatics for Unstructured Meshes
Authors: Zhang Jiayi Eris , Dumas Jérémie , Fei Yun (Raymond) , Jacobson Alec , James Doug L. , Kaufman Danny M. 
Published: December 2023

Thin shell structures exhibit complex behaviors critical for modeling and design across wide-ranging applications. Capturing their mechanical response requires finely detailed, high-resolution meshes. Corresponding simulations for predicting equilibria with these meshes are expensive, whereas coarse-mesh simulations can be fast but generate unacceptable artifacts and inaccuracies. The recently proposed progressive simulation framework [Zhang et al. 2022] offers a promising avenue to address these limitations with consistent and progressively improving simulation over a hierarchy of increasingly higher-resolution models. Unfortunately, it is currently severely limited in application to meshes and shapes generated via Loop subdivision.
We propose Progressive Shells Quasistatics to extend progressive simulation to the high-fidelity modeling and design of all input shell (and plate) geometries with unstructured (as well as structured) triangle meshes. To do so, we construct a fine-to-coarse hierarchy with a novel nonlinear prolongation operator custom-suited for curved-surface simulation that is rest-shape preserving, supports complex curved boundaries, and enables the reconstruction of detailed geometries from coarse-level meshes. Then, to enable convergent, high-quality solutions with robust contact handling, we propose a new, safe, and efficient shape-preserving upsampling method that ensures non-intersection and strain limits during refinement. With these core contributions, Progressive Shell Quasistatics enables, for the first time, wide generality for progressive simulation, including support for arbitrary curved-shell geometries, progressive collision objects, curved boundaries, and unstructured triangle meshes - all while ensuring that preview and final solutions remain free of intersections. We demonstrate these features across a wide range of stress-tests where progressive simulation captures the wrinkling, folding, twisting, and buckling behaviors of frictionally contacting thin shells with orders-of-magnitude speed-up in examples over direct fine-resolution simulation.
RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma
Authors: Yu Pengfei , Cao Shuwen , Yang Shyh-Ming , Rai Ganesha , Martinez Natalia J. , Yasgar Adam , Zakharov Alexey V. , Simeonov Anton , Molina Arocho William A. , Lobel Graham P. , Mohei Hesham , Scott Alexis L. , Zhai Li , Furth Emma E. , Simon M. Celeste , Haldar Malay 
Published: December 2023

Abstract
Globally, hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and a leading cause of cancer-related death. We previously identified an immune evasion pathway whereby tumor cells produce retinoic acid (RA) to promote differentiation of intratumoral monocytes into protumor macrophages. Retinaldehyde dehydrogenase 1 (RALDH1), RALDH2, and RALDH3 are the three isozymes that catalyze RA biosynthesis. In this study, we have identified RALDH1 as the key driver of RA production in HCC and demonstrated the efficacy of RALDH1-selective inhibitors (Raldh1-INH) in suppressing RA production by HCC cells. Raldh1-INH restrained tumor growth in multiple mouse models of HCC by reducing the number and tumor-supporting functions of intratumoral macrophages as well as increasing T-cell infiltration and activation within tumors. Raldh1-INH also displayed favorable pharmacokinetic, pharmacodynamic, and toxicity profiles in mice thereby establishing them as promising new drug candidates for HCC immunotherapy.
Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages
Authors: Manara Maria Cristina , Manferdini Cristina , Cristalli Camilla , Carrabotta Marianna , Santi Spartaco , De Feo Alessandra , Caldoni Giulia , Pasello Michela , Landuzzi Lorena , Lollini Pier-Luigi , Salamanna Francesca , Dominici Sabrina , Fiori Valentina , Magnani Mauro , Lisignoli Gina , Scotlandi Katia 
Published: December 2023

Abstract
Ewing sarcoma (EWS) is the second most common pediatric bone tumor. The EWS tumor microenvironment is largely recognized as immune-cold, with macrophages being the most abundant immune cells and their presence associated with worse patient prognosis. Expression of CD99 is a hallmark of EWS cells, and its targeting induces inhibition of EWS tumor growth through a poorly understood mechanism. In this study, we analyzed CD99 expression and functions on macrophages and investigated whether the concomitant targeting of CD99 on both tumor and macrophages could explain the inhibitory effect of this approach against EWS. Targeting CD99 on EWS cells downregulated expression of the “don't eat-me” CD47 molecule but increased levels of the “eat-me” phosphatidyl serine and calreticulin molecules on the outer leaflet of the tumor cell membrane, triggering phagocytosis and digestion of EWS cells by macrophages. In addition, CD99 ligation induced reprogramming of undifferentiated M0 macrophages and M2-like macrophages toward the inflammatory M1-like phenotype. These events resulted in the inhibition of EWS tumor growth. Thus, this study reveals what we believe to be a previously unrecognized function of CD99, which engenders a virtuous circle that delivers intrinsic cell death signals to EWS cells, favors tumor cell phagocytosis by macrophages, and promotes the expression of various molecules and cytokines, which are pro-inflammatory and usually associated with tumor regression. This raises the possibility that CD99 may be involved in boosting the antitumor activity of macrophages.
Active Predictive Coding: A Unifying Neural Model for Active Perception, Compositional Learning, and Hierarchical Planning
Authors: Rao Rajesh P. N. , Gklezakos Dimitrios C. , Sathish Vishwas 
Published: December 2023

Abstract
There is growing interest in predictive coding as a model of how the brain learns through predictions and prediction errors. Predictive coding models have traditionally focused on sensory coding and perception. Here we introduce active predictive coding (APC) as a unifying model for perception, action, and cognition. The APC model addresses important open problems in cognitive science and AI, including (1) how we learn compositional representations (e.g., part-whole hierarchies for equivariant vision) and (2) how we solve large-scale planning problems, which are hard for traditional reinforcement learning, by composing complex state dynamics and abstract actions from simpler dynamics and primitive actions. By using hypernetworks, self-supervised learning, and reinforcement learning, APC learns hierarchical world models by combining task-invariant state transition networks and task-dependent policy networks at multiple abstraction levels. We illustrate the applicability of the APC model to active visual perception and hierarchical planning. Our results represent, to our knowledge, the first proof-of-concept demonstration of a unified approach to addressing the part-whole learning problem in vision, the nested reference frames learning problem in cognition, and the integrated state-action hierarchy learning problem in reinforcement learning.
Lions and Tigers and Bears, Oh My: Imprisoned Animals and Humans in the Acts of Paul
Authors: Reiss Naomi 
Published: December 2023

Abstract
This paper will explore the carceral logics affecting nonhuman and human animals in a popular second-century Christian text, the Acts of Paul. Two parallel scenes feature imprisoned animals pitted against imprisoned humans in the punitive entertainment spectacle of the amphitheater. Through these scenes, this paper will examine the ancient practice of animal captivity, the “de-animalizing” effects of imprisonment on human and nonhuman victims, and the problematic witness of early Christian writings to these phenomena as the texts, and the humans in them, variously exploit, fear, threaten, anthropomorphize, are protected by, compete with, and enter into solidarity with other imprisoned animals. Finally, it will discuss the (potentially) inclusive role of this text in naming animals as “confessors,” or imprisoned, suffering witnesses to the gospel, in a carcerally-controlled world.
Hearing their Cries: A Talanoa Response
Authors: Fiu Kolia Brian 
Published: December 2023

Abstract
This essay is a response to the stimulating contributions to this volume, by way of hearing. Here, I use the Indigenous Pasifika form of interrogation known as talanoa that allows us to hear and enter into the subconcious state, to perceive the world of animals from these alternative perspectives, which seek to liberate animal voices and push back at colonial systems that are guilty of meddling with our reading and theorizing of the animal-Other. This talanoa allows us to imagine the contributors sitting around a kava bowl in conversation, as we hear them tell their stories, and hear the humour, the pain, the honesty in the animal experiences.
The Power of Curves: the Rise of Maghribi ṯuluṯ (Fifth–Sixth/Eleventh–Twelfth Centuries)
Authors: Bongianino Umberto 
Published: December 2023

Abstract
This article examines the origin and spread of Maghribi ṯuluṯ, a distinctive epigraphic style employed on buildings and inscribed artefacts in Northwest Africa and al-Andalus, from the late fifth/eleventh century onwards. The rise of Maghribi ṯuluṯ is part of a wider phenomenon that saw curvilinear scripts adopted in contexts and media previously dominated by angular “Kufic” scripts throughout the Islamic world, from Ghazna to Marrakesh. However, the circumstances of this epigraphic revolution differed from region to region, as did the techniques and stylistic features of the new curvilinear inscriptions. The development of Maghribi ṯuluṯ was the result of influences coming from the Eastern Mediterranean, assimilated and transformed in different ways within the cultural and artisanal milieux of Norman Sicily, Khurasanid Tunis, and the Almoravid Empire further west. This article considers the possible channels through which Maghribi ṯuluṯ spread across these regions – with an emphasis on chancery documents and practices – and how the Almohads ultimately transformed this script into a dynastic “brand” with ideological undertones.
The Merchant’s Lamp and the Sufi’s Drum: Two Tales of Mediaeval Damascus
Authors: Juvin Carine 
Published: December 2023

Abstract
A few artefacts can be connected to mediaeval Syria, and more specifically Damascus, through their inscriptions because they mention the city as a place of manufacture or name an individual who lived there. This is notably the case for two hitherto neglected inscribed objects in the Musée du Louvre, dating to the Mamluk sultanate, which are studied in this article: an enamelled glass lamp and a metal drum. New identifications of their recipients, documented through historical sources, bring light to their particular stories and provide new references for studying the material and social culture during this period.
Discovering Early Islamic Basra: the Origins and Development of Iraq’s Southern Metropolis
Authors: Petersen Andrew , Northedge Alastair , Stremke Frank , Bates Martin , Edwards Ifan 
Published: December 2023

Abstract
This article reports on recent fieldwork at the site of the early Islamic city Basra, located fifteen kilometres to the southwest of the modern city. The article sets the site within the geographical and historical context of early Islamic Iraq with particular reference to Kufa and Wāsit. In addition, the article contains a review of previous archaeological research followed by a summary of the results from current fieldwork carried out by the authors. Finally, this text highlights the need for further fieldwork both to answer research questions and protect the valuable heritage of Iraq’s first Muslim city.
Patients with systemic lupus erythematosus who are underweight have distinct disease characteristics
Authors: Kwon Oh Chan , Park Min-Chan 
Published: December 2023

Objective This study aimed to detail the disease characteristics of systemic lupus erythematosus (SLE) in individuals who are underweight and assess whether underweight status is associated with SLE disease activity. Methods This was a retrospective cohort study involving 218 patients newly diagnosed with SLE. Patients were categorized as underweight (body mass index [BMI] <18.5 kg/m2) or not underweight (BMI ≥18.5 kg/m2). We reviewed disease characteristics including the SLE Disease Activity Index 2000 (SLEDAI-2K) at diagnosis. High disease activity was defined as SLEDAI-2K ≥10. Disease characteristics were compared between those who were underweight and not underweight. We used multivariable logistic regression analysis to determine whether underweight status is associated with high disease activity. Results Out of the 218 patients, 35 (16.1%) were underweight and 183 (83.9%) were not. Underweight patients had less renal involvement (5.7% vs 20.2%, p = .040), lower C-reactive protein levels (1.0 [0.3–2.3] mg/L vs 1.2 [0.8–5.0] mg/L, p = .028), and lower SLEDAI-2K scores (6.7 ± 4.6 vs 9.1 ± 5.7, p = .009), and were less likely to be at high disease activity status (22.9% vs 42.6%, p = .028), compared with those who were not underweight. Following adjustment for multiple covariates, being underweight was inversely associated with high disease activity status (adjusted odds ratio = 0.38, 95% confidence interval = 0.16 to 0.92, p = .031). Conclusion Patients with SLE who were underweight showed less renal involvement and lower SLEDAI-2K scores compared with those who were not underweight. Moreover, those with SLE who were underweight had a 60% lower risk of exhibiting high disease activity.
Coprophilia and Coprophagia: A Literature Review
Authors: Arnone Jacqueline M. , Conti Richard P. , Preckajlo Joseph H. 
Published: December 2023

BACKGROUND: Coprophilia and coprophagia are distinct paraphilias that fall under the category of other specified paraphilic disorders in the current edition of the Diagnostic and Statistical Manual of Mental Disorders. Coprophilia refers to sexual excitement from viewing, smelling, or handling feces, as well as fantasizing about another person engaging in these activities. Coprophagia, or eating one’s own or another person’s excrement, has also been observed in some patients with coprophilia. AIMS: The purposes of this review are to examine the current literature on the etiology, symptoms, interviewing techniques, pharmacotherapy, and psychotherapy used for each disorder and to elicit best practice guidelines in the treatment of patients with coprophila and coprophagia. METHODS: Electronic and hand searches were initiated using CINAHL, EBSCOhost, SAGEpub, and MEDLINE databases between 1990 and 2022 using the terms “coprophilia,” “coprophagia,” “paraphilia NOS,” and “other specified paraphilic disorder” restricted to English. RESULTS: Individual case reports and limited studies were found in this literature. Reported treatment protocols included individual and tandem use of pharmacotherapy and psychotherapy, with mixed outcomes. Future studies are needed to explore the factors that mitigate the paraphilias, therapeutic management, and treatment outcomes, to produce evidence-based practice treatment guidelines. CONCLUSIONS: Understanding the psychological and biological factors that may contribute to these disorders’ manifestations may portend a greater understanding and insight into the genesis of the paraphilias. Having specific evidence-based treatment protocols will afford the psychiatric nurse practitioner to render patient-centered, safe, and culturally competent care and effect better patient outcomes among this understudied population.
Zone 2 Aortic Arch Repair With Single-Fenestrated Physician-Modified Endografts, at Least 3 Years of Follow-up
Authors: Bacri Christoph , Ata Ozdemir Baris , Hireche Kheira , Alric Pierre , Canaud Ludovic 
Published: December 2023

Objective: The aim of this study is to report the efficiency and safety of single-fenestrated physician-modified endografts (PMEGs) in zone 2 aortic arch pathologies with at least 3 years of follow-up. Methods: All consecutive patients with a pathological aortic arch who underwent aortic repair combined with homemade single-fenestrated stent-graft from 2015 to 2020 were reviewed. The patients with a target vessel different from the left subclavian artery (LSA) were excluded. Results: A total of 63 patients were treated for a pathological arch in zone 2 with a single-fenestrated PMEG. 73% were male, and the mean age was 65 years old. 25% were treated for a degenerative aneurysm, 19% for a post dissection aneurysm and 24% for an acute type B dissection. 52% of the patients were treated as an emergency and half of those for an aortic rupture. The LSA fenestration was stented in 70%. During 30 days of follow-up, 2 strokes (3%) were reported, 6 patients (10%) died with 4 of those treated for aortic rupture and 1 had a retrograde aortic dissection. During at least 3 years of follow-up (median 49 months), no reintervention was needed for endoleaks, there was no stent fracture or stent migration. No patient died from an aortic cause. Subgroup analysis comparing the endovascular treatment for various aortic pathologies did not find significant differences in death rate or comorbidity including stroke. When comparing emergent and elective aortic repair, operating time was similar (64 vs 65 minutes), and the LSA fenestration was less frequently stented (52%) in the emergency group. There was no difference in stroke frequency. There was a higher rate of death in the emergency group at 30 days of follow-up, but no patient died from aortic cause in the long-term follow-up. Conclusions: Aortic arch repair with single-fenestrated PMEGs for zone 2 pathological arch disease is associated with acceptable early and midterm major morbidity and mortality. It is suitable for emergency situations. Clinical Impact Single-fenestrated PMEG for the left subclavian artery is a safe and efficient option in the short and medium term for the treatment of the aortic arch in zone 2 with 98% technical success. It allows for aortic repair and subclavian artery revascularization in a single step for all patients. It is suitable for a range of main pathologies, including degenerative, dissection-related, isthmus rupture, and embolic pathologies. Additionally, it is always available and easily utilized in emergency cases.