bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Lipid-based Nanocarriers to Improve Ovarian Cancer Treatment: An Overview of Recent Developments
Authors: Tantray Junaid , Patel Akhilesh , Prajapati Bhupendra G. , Kosey Sourabh , Bhattacharya Sankha 
Published: February 2024

:
Ovarian cancer poses a formidable health challenge for women globally, necessitating
innovative therapeutic approaches. This review provides a succinct summary of the current research status on lipid-based nanocarriers in the context of ovarian cancer treatment. Lipid-based
nanocarriers, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid
carriers (NLCs), offer a promising solution for delivering anticancer drugs with enhanced therapeutic effectiveness and reduced adverse effects. Their versatility in transporting both hydrophobic and hydrophilic medications makes them well-suited for a diverse range of anticancer drugs.
Active targeting techniques like ligand-conjugation and surface modifications have been used to
reduce off-target effects and achieve tumour-specific medication delivery. The study explores
formulation techniques and adjustments meant to enhance drug stability and encapsulation in
these nanocarriers. Encouraging results from clinical trials and preclinical investigations underscore the promise of lipid-based nanocarriers in ovarian cancer treatment, providing optimism
for improved patient outcomes. Notwithstanding these advancements, challenges related to
clearance, long-term stability, and scalable manufacturing persist. Successfully translating lipidbased nanocarriers into clinical practice requires addressing these hurdles. To sum up, lipidbased nanocarriers are a viable strategy to improve the effectiveness of therapy for ovarian cancer. With their more focused medication administration and lower systemic toxicity, they may
completely change the way ovarian cancer is treated and increase patient survival rates. Lipidbased nanocarriers need to be further researched and developed to become a therapeutically viable treatment for ovarian cancer.
Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Scaphium Affine Seed Extract and Assessment of Its Anti-hemorrhoidal Efficacy
Authors: Abbas Syed A. , Khan Abdullah , Fatima Mehraj , Kalusalingam Anandarajagopal , Kanakal Mahibub M. , Inamdar Shiva K. , Kotra Vijay , Ming Long C. , Dastapur Ashok K.M. , Bachi Tazneem 
Published: February 2024

Background:
Seeds of plant Scaphium affine are traditionally used by the healers of “In-dia” for the treatment of piles.

Objectives:
The primary objective of the study was to assess the anti-hemorrhoidal potential of the ethanolic seed extract of Scaphium affine.

Methods:
After the soxhlet extraction method, the seed extract from Scaphium affine was first sub-mitted to phytochemical standardization and then GC-MS analysis. Rats were given Croton oil and Jatropha oil to develop hemorrhoids, and Scaphium affine seed extract (ESA) was administered orally for 5 days and 3 days, respectively, at doses of 1000 and 500 mg/kg. The Rectoanal coefficient (RAC) was calculated as an inflammatory marker. The hemorrhoidal tissues were also subjected to cytokine profiling, biochemical estimation and histopathology.

Results:
ESA demonstrated the presence of flavonoids, saponins, phytosterols, phenols, and tannins. GCMS analysis elucidated the presence of hexadecanoic acid 2 hydroxy -1,3 propane diyl ester,9 Octadecanoic acid ethyl ester, Cyclohexane 1,4 di methyl cis, Farnesol isomer,1, E-11, Z-13 octa decatriene, Stigmasterol, N-(5 ethyl -1,3,4-thiadiazol-yl) benzamide, N, N Dinitro 1,3,5,7 tetraza bicyclo 93,3,1) as major phytoconstituents. The results depicted more potent anti-hemorrhoidal ac-tivity of ESA at 1000 mg/kg, p.o., which was evident through a decrease in RAC. A significant decline in the levels of IL-1β, IL-6, and TNF-α expression was observed, along with the restoration of altered antioxidants and enzymes. Histopathological analysis confirmed the tissue recovery as it revealed minimal inflammation and decreased dilated blood vessels in treated animals.

Conclusion:
Based on the results it can be concluded that seeds of Scaphium affine showed signifi-cant anti-hemorrhoid agents which may be attributed to their anti-inflammatory and anti-oxidant potential due to the presence of certain phytoconstituents in it. The study also supports the traditional use of seeds of Scaphium affine for the first time in the treatment of hemorrhoids.
Computer-guided Surgery in Anterior Esthetic Area with Autologous Deciduous Tooth-Derived Material: Case Report
Authors: Ceraulo Saverio , Carini Fabio , Viscardi Daniele , Cesca Alessandro , Biagi Roberto 
Published: February 2024

Background
The literature has described several biomaterials for guided bone regeneration. Some authors have proposed using a material derived from dentin/ enamel among autologous biomaterials. This study aims to test the effectiveness of autologous material derived from deciduous teeth in guided bone regeneration.

Case Presentation
A 24-year-old female shows up with missing tooth #1.1 for a domestic accident. This requires implant-prosthetic rehabilitation. It is decided to be performed before implant therapy, a bone regeneration guided using biomaterial resulting from the patient’s deciduous teeth stored in a plastic box. GBR (Guided Bone Rehabilitation) is performed, and after 6 months, the implant is inserted by computer-guided surgery, and then a provisional prosthesis is placed.

Discussion
The material deriving from deciduous teeth, not preserved with precautions, has had excellent integration results. This allowed the implant to be placed in the best position for the final prosthetic rehabilitation.

Conclusion
This clinical case shows that using biomaterial derived from deciduous teeth has allowed an excellent result with negligible biological cost.
Health-promoting Lifestyle and Predicting Anxiety Caused by COVID-19 In Medical Sciences Students
Authors: Amiri Mohammad , Mikal Zahra Mehmannavaz , Sadeghi Elham , Khosravi Ahmad 
Published: February 2024

Objectives:
In recent years, the COVID-19 pandemic has altered the daily lives of people around the globe and caused significant mortalities and public health issues. The objective of the current study was to determine the role of health-promoting behaviors in predicting anxiety caused by COVID-19 in Shahroud University of Medical Sciences students in 2022.

Methods:
This cross-sectional study included 350 students from various medical sciences who were chosen through a multi-stage stratified random sampling process. We gathered the necessary information by administering health-promoting lifestyle and COVID-19-related anxiety questionnaires. This inventory has 18 items and is scored on a 4-point Likert scale. The range score is between 0 and 54. The data were analyzed by ANOVA, Chi-square, and Pearson's correlation coefficient. All tests have a significance level of 0.05.

Results:
Based on lifestyle questionnaire scores, 51 students (15%) had a poor lifestyle, 272 (79.8%) had an average lifestyle, and 18 (5.3%) had a good lifestyle. Anxiety averaged 6.20±6.18, and health-promoting lifestyle averaged 123.64±19.05. Health-promoting lifestyle did not correlate with COVID-19 anxiety. Stress management, nutrition, and physical activity scored the lowest. Academic semester (p=0.03), family income (p=0.006), and marital status (p=0.03) were associated with Covid-19 anxiety.

Conclusion:
Students had low COVID-19 anxiety and average health-promoting lifestyles. Despite initial concerns, the data showed no significant association between COVID-19 anxiety and the students' vaccination status. However, it's worth noting that vaccination has the potential to reduce anxiety among students. Stress management, nutrition, and physical activity can improve student lifestyles.
Fact or Fiction: Accelerometry versus Self-Report in Adherence to Pediatric Concussion Protocols, A Prospective Longitudinal Cohort Study (Preprint)
Authors: DeMatteo Carol , Randall Sarah , Jakubowski Josephine , Stazyk Kathy , Obeid Joyce , Noseworthy Michael , Mazurek Michael , Timmons Brian W , Connolly John , Giglia Lucy , Hall Geoffrey , Lin Chia-Yu , Perrotta Samantha 
Published: February 2024

BACKGROUND

Our research team developed evidence-based Return to Activity and Return to School protocols for youths with concussion which are based on the Sports Concussion Consensus statements and the main management strategy for concussion recovery.

OBJECTIVE

It is important to determine if youth with concussion adhere to these protocols before evaluation in randomized control trials. Youth who were more adherent would have a lower incidence of repeat injury, shorter times to Return to Activity and better outcomes in quality of life, mental health, and cognition measures.

METHODS

Participants were recruited from the Hospital Emergency Department, community referrals from their primary physician, and rehabilitation or sports medicine clinics. Youths (N=139) aged 5-18 with concussion. In this prospective longitudinal cohort study, self-reported symptoms and protocol stage of recovery were monitored every 48 hours until symptom resolution. Daily accelerometry data was collected. Participants were evaluated using a battery of measures at 3 time points. Participants were not blinded or randomized.

RESULTS

For Return to Activity Stage 1, 13% of participants were adherent. 11% and 34% of participants were adherent for Stage 2 and 3, respectively. The median time to symptom-resolution for participants who self-reported adherence to the Return to Activity protocol was 13 days and 20 days for those who self-reported non-adherence (p=0.03). The re-injury rate among the cohort was 2% (N=3).

CONCLUSIONS

Adherence to staged protocols post-concussion was minimal when assessed with accelerometers, but higher by self-report. More physical activity restrictions resulted in lower adherence. Although adherence was low, re-injury rate was low suggesting a protective effect of monitoring and Return to Activity protocols. The results of this study support an ease in protocols and earlier resumption of activities.
Sirenas y jícaras en el arte verbal y en la materialidad oral americana.
Authors: Crolla Adriana Cristina 
Published: February 2024

Sabemos que los monstruos participan desde los orígenes de las cosmogonías. Son la encarnación del mal o el caos que amenaza constantemente el orden cósmico. Por ello el hombre se inventó historias para que en su transmisión operaran como talismanes o salvoconductos que libraran o educaran ante los peligros de la naturaleza y, ente lo femenino, en estrecha conjunción. En este sentido el hombre percibió desde antiguo la relación del astro nocturno con todo aquello que comporta ciclos y fluidez, aproximando la luna a lo femenino, a la pérdida, la transformación y lo mortuorio. Las figuras de las brujas, vampiros y sirenas configuran diferentes resoluciones de este mismo ancestral tabú. Pero la importancia de la sirena se manifiesta en la pervivencia y modulaciones adquiridas en diferentes culturas y tiempos y el modo cómo quedaron inscriptas en artefactos literarios y en la oralidad.
Efficiency of ozone (O3) therapy on experimental acidic skin burns in rats
Authors: Nevzat Emre Aslan , Erol Hanifi , Balcıoğlu Esra , Betül Yalçin 
Published: February 2024

In this study, it was aimed to investigate the efficacy of O3 therapy in experimentally induced HF skin burns in rats. A total of 20 healthy male Wistar Albino rats (weighing 250-300 g, aged 16 weeks) were used as the material of the study. They were divided into two groups (as experimental and control groups) of 10 rats which were housed individually and fed ad libitum. Hydrofluoric acid (HF) skin burns were induced in all animals. The ozonized (20 µg O3/mL) liquid vaseline was applied topically for seven days to the experiment group as well as parallelly, a saline solution was applied to the control group. In the histopathologic evaluation, inflammation, vascularization, epithelial regeneration and fibrosis were evaluated.
The epithelial proliferation and collagenization were higher and statistically significant in the experimental group, while the infiltration was higher and statistically significant in the control group. As a result of this study, it was observed that ozone plays an important role in the tissue repair process in chemical burns. The increase of fibroblast activation and re-epithelization in the experimental group demonstrated that ozone therapy could be suggested as first aid in HF skin burns. It was concluded that more studies on ozone are needed to shed light on the subject.
Relative Liability Exposure for Negligence and Financial Reporting Quality: Evidence from the Audit Interference Rule
Authors: Mayberry Michael A. , Park Hyun Jong , Zhang Wei 
Published: February 2024

ABSTRACT
We examine how the shifting of legal liability between auditors and clients affects financial reporting quality. We exploit the state-level adoption and rejection of a common law doctrine, the Audit Interference Rule (AIR), which shifts legal liability between auditors and clients, while not affecting total legal liability. The likelihood of restatements declines following staggered rejections of the AIR that shift risk to clients. Path analysis indicates that audit fees increase following AIR rejections, suggesting that relatively greater liability exposure for clients leads to a greater demand for assurance services that, in turn, reduces the likelihood of restatements. We further find greater improvements in financial reporting quality following the rejections of the AIR among clients with higher litigation risk and larger clients. Broadly, we provide novel evidence that clients’ incentives relating to increased liability exposure appear to dominate auditors’ disincentives relating to decreased liability exposure on financial reporting quality.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: K15; M41; M42.
The war in Ukraine and the risk of low impact of Western sanctions imposed on Russia
Authors: Pera Jacek 
Published: February 2024

In 2022, the Russian Federation became the most sanctioned country on Earth due to its full-scale invasion of Ukraine. The aim of this article is to measure the effectiveness of the economic sanctions adopted against the Russian Federation. The research main hypothesis was the following: the impact of Western sanctions imposed on Russia caused by the war in Ukraine remains low. The research methodology was based on literature research and a linear regression model with two variables: dependent and independent. The results of the study lead to the following conclusions: 1.Sanctions adopted on Russia since 2014 and since 2022 have a direct negative impact on Russian trade (imports and exports in value) with the EU countries and the US. 2.Sanctions adopted against Russia since 2014 and 2022 have a direct negative impact on its trade (imports and exports in value) with the trade partners that have a neutral position concerning the war.
The Influence of Career Women’s Rejection of Polygamy on Children’s Personality (Case Studi in Batu Aji District, Batam City)
Authors: Nada Izzatun Nisa  , Muhammad Nurul Fahmi  
Published: February 2024

Diangkatnya judul ini karena situasi dialami oleh mayoritas para wanita yang sudah menikah di Indonesia khususnya di Kecamatan Batu Aji, Batam. Dimulai dari angka cerai gugat di Batam yang dilakukan istri terhadap suaminya pada 2022 akhir mencapai 1.505 kasus. Sedangkan dari pihak suami yang mengajukan talak hanya 541 kasus. Solusi poligami yang disyariatkan oleh agama justru mendulang masalah internal dalam keluarga. Yang terjadi adalah, para istri lebih memilih mengajukan cerai gugat dan bekerja sendiri untuk memenuhi kebutuhan rumah tangga serta mendidik anak di rumah daripada harus menjalankan syariat tersebut. Peran ganda ibu rumah tangga sekaligus pencari nafkah inilah yang akhirnya berimpas pada kepribadian anak-anak di rumah. Dimulai dari segi psikologi, akhlak, emosi bahkan pendidikan. Tujuan penelitian ini adalah: (1) menganalisis dan menemukan fenomena penolakan poligami yang dilakukan oleh wanita karier di Kecamatan Batu Aji, Batam, dan (2) menganalisis dan menemukan dampak penolakan poligami terhadap kepribadian anak di rumah. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis studi kasus. Objek penelitian ini adalah masyarakat Kecamatan Batu Aji, Kota Batam. Teknik pengambilan data yaitu dengan survey kuesioner, wawancara dan observasi. Hasil dari penelitian ini menunjukkan bahwa: (1) penolakan poligami bukan terjadi karena tidak menyetujui syariat, terdapat pelaksanaan poligami yang salah dan ada lima faktor poligami tertolak, dan (2) tantangan terberat dalam menyeimbangkan berkarier dan mengurus anak adalah waktu dan terdapat empat pengaruh penolakan poligami pada anak.
Kata kunci: penolakan poligami; wanita karier; kepribadian anak.
Research on the Construction and Application of Network Civic Education Platform in Colleges and Universities in the Information Age
Authors: Su Shuwan 
Published: February 2024

Abstract
Clarifying the construction concept of network ideological and political education platforms in colleges and universities is a requirement to grasp the fundamental direction of network ideological and political education. This paper combines the Actor-critic algorithm with the state representation model and decision-making model to construct a network ideological and political education platform with the functions of education, management, service, dissemination, socialization, and practice. After the practical application of the Civic and Political Education Platform, the recognition and satisfaction of the platform are analyzed through questionnaire surveys. Finally, the Civic and Political Learning Achievement Quiz is conducted for college students at different stages to analyze the positive effect of the platform on the Civic and Political Learning Effect. The results show that in the four dimensions such as recognition, the p-value is less than 0.05, indicating that the difference between the experimental class and the control class is significant. Specifically, analyze the indicators of each dimension. Perceived resource richness, Guangzhou region satisfaction 3.8 is higher than the other three regions. Perceived resource quality perceived Shenzhen region is 3.68, higher than the other three regions, followed by Guangzhou. By the third stage, the average scores of the experimental group and the control group were 90.8 and 84.3, respectively, with a p-value of 0.008, indicating that the online education platform is becoming more and more effective in the learning of Civics and Politics for students in colleges and universities with time.
Digital Application of Folk Culture Elements in City Branding Visual Identity Shaping
Authors: Wang Qing 
Published: February 2024

Abstract
In this paper, for the visual image shaping of folk culture elements in city branding, the intelligent extraction technology of digital image with image pre-processing, color space conversion, and color extraction as the three core modules is proposed. In terms of image preprocessing, spatial domain filtering is used as a means to explore the two main algorithms of linear filtering and nonlinear filtering, and in the color space conversion module, the RGB color space is converted to the CIE Lab color space with the help of CIE XYZ color. The color map extraction module uses Python language to construct the color collocation relationship network using K-means and color adjacency matrix visualization. Finally, the quantitative experiment on the effect of the city brand visual image that integrates the elements of folk culture is carried out, and 65 city brand visual image samples are quantitatively analyzed, while the AMOS model is applied to test the city brand visual image.
Diversity Design of Traditional Cultural Elements in Interior Design Based on Combinatorial Optimization Algorithm
Authors: Wen Xiao 
Published: February 2024

Abstract
There are great limitations in the imagination and play space of traditional interior design methods, and it is very costly to make changes after the design is completed. For this reason, this paper combines and optimizes SIFT and image splicing methods to recognize traditional cultural elements in images. Gray scale processing is performed on the image, unstable edge response points are removed and low contrast feature points are filtered, and the Gaussian pyramid is established by convolving the image with the Gaussian kernel function under different scale factors to establish the dimensions of the feature points. On this basis, an image splicing optimization algorithm that combines the two-dimensional information entropy of the image is proposed to divide the image into detail regions and flat regions, assign corresponding weights to the feature points in the optimization stage of the uni-responsive matrix, and minimize the residual sum to obtain the optimal uni-responsive matrix using the Levenberg-Marquardt algorithm, to improve the splicing quality. In the actual design test, the Chinese chair has the lowest success rate of 94.1%, and the output quality is 0.9215 and 0.9527. The output quality decreases as the scene becomes more complex. The SSIM and DoEM values for the Chinese chair are 0.9582 and 0.9682 for a simple scenario and decrease to a minimum of 0.8543 and 0.8472 as the number of interior pieces and other items in the scenario increases. By proposing the approach in this paper, labor costs and expenses can be saved and a new direction for interior design development can be taken.
Artificial Intelligence Technology Empowers Practical Teaching of Higher Vocational Accounting Majors
Authors: Wu Jian , Chen Xuemei , Zhang Yuan , Wang Hui 
Published: February 2024

Abstract
This paper proposes an interactive study of online practice teaching based on LightGBM model. To avoid the overfitting of training data by LightGBM model, the objective function of LightGBM model is derived utilizing GBDT gradient boosting tree to optimize the overfitting problem of training data. Based on the interactive study of online practice teaching based on the LightGBM model, the construction of the accounting practice teaching system is completed by using B/S mode, and the simulation analysis of online practice teaching of accounting majors in the context of the artificial intelligence era is carried out. The results show that the students in class C, with an AUC value of 0.819, are higher than that before optimization by 0.095, and similarly comparing the AUC values of other classes are higher than that before optimization. The LightGBM model optimized by the grid search algorithm can effectively identify and interact with students’ accounting practice behavioral characteristics, and to a certain extent, effectively predict students’ accounting practice ability. This study has the potential to guide students in mastering accounting practice knowledge, guaranteeing quality practice teaching, and fostering the growth of accounting professionals.