bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Radiographic Outcome in the Management of Posterior Circulation Aneurysms by Use of Direct Surgical or Endovascular Techniques
Authors: Ogilvy Christopher S. , Hoh Brian L. , Singer Robert J. , Putman Christopher M. 
Published: July 2004

Abstract

OBJECTIVE
Posterior circulation aneurysms can be difficult lesions to treat surgically, and they have potential for high morbidity and mortality, particularly in elderly patients or those in poor neurological condition. In an effort to improve outcomes, our combined neurosurgical and neuroendovascular unit has used both surgical clipping and endovascular coiling techniques to treat posterior circulation aneurysms. Patients considered at high risk for surgery were managed with endovascular treatment.

METHODS
From 1990 to 1998, 197 posterior circulation aneurysms in 189 patients were treated in our combined neurovascular unit. Of these aneurysms, 128 were ruptured, 63 were unruptured, and 6 had a distant history of rupture in patients who came to our center for delayed or repeat treatment. A total of 132 aneurysms were treated with surgical clipping (85 ruptured, 46 unruptured, and 1 with distant history of rupture) and 65 aneurysms were treated with endovascular coiling (43 ruptured, 17 unruptured, and 5 with distant history of rupture). Dissecting aneurysms of the vertebral or posteroinferior cerebellar arteries or aneurysms treated with proximal (Hunterian) occlusion were excluded from this analysis. Surgical risk was assessed using a previously described system (Massachusetts General Hospital [MGH] grade), which incorporates age, Hunt and Hess grade, size of lesion, and Fisher grade.

RESULTS
Overall clinical outcomes at 1 year of follow-up were 77.2% excellent or good, 10.2% fair, 4.1% poor, and 8.6% dead. Surgical treatment resulted in 95.6% complete aneurysm occlusion and 4.4% with residual aneurysm after surgical treatment, whereas endovascular treatment resulted in 32.3% complete occlusion, 26.2% with residual aneurysm, and 41.5% with partial occlusion. In most cases, however, treatment with Guglielmi detachable coils (Boston Scientific/Target, Fremont, CA) was performed for palliation rather than complete radiographic occlusion. Outcome was closely associated with MGH grade with either treatment modality. Excellent/good outcomes were achieved in 96, 92.3, 82.9, 46.2, and 0% of surgically treated patients with MGH Grades of 0, 1, 2, 3, and 4, respectively. In comparison, excellent/good outcomes were achieved in 100, 84.2, 61.9, 0, and 50% of endovascularly treated patients with MGH Grades of 0, 1, 2, 3, and 4, respectively.

CONCLUSION
A combined surgical and endovascular approach to posterior circulation aneurysms can achieve good outcomes in high-risk surgical patients treated by use of coiling techniques.
Malignant Pineal Parenchymal Tumors in Adult Patients: Patterns of Care and Prognostic Factors
Authors: Lutterbach Johannes , Fauchon François , Schild Steven E. , Chang Susan M. , Pagenstecher Axel , Volk Benedikt , Ostertag Christoph , Momm Felix , Jouvet Anne 
Published: July 2004

AbstractOBJECTIVEThe aim of our study was to analyze patterns of care and to identify prognostic factors in patients at least 18 years of age who received radiotherapy for malignant pineal parenchymal tumors.METHODSIn a multicenter, retrospective study, we analyzed data for 37 previously published cases and 64 patients treated at the participating institutions.RESULTSA total of 56 patients received postoperative radiotherapy, and 45 patients received primary radiotherapy. Chemotherapy was administered to 34 patients. The median follow-up period was 38 months, and median overall survival was 100 months. The variables that significantly influenced overall survival were the extent of disease (localized versus disseminated; P = 0.0002), differentiation (pineal parenchymal tumor of intermediate differentiation versus pineoblastoma; P = 0.001), and residual disease (≥50% versus &lt;50% reduction in size; P &lt; 0.0001). In a multivariate analysis, the parameters turned out to be independent risk factors. The median survival in patients with local or spinal failure was 15 months. Local control was better in older patients (≥32 yr versus &lt;32 yr; P = 0.02). Spinal control was more successful in patients with pineal parenchymal tumors of intermediate differentiation than it was in patients with pineoblastomas (P = 0.03). Nine of 45 treatment failures occurred later than 5 years after treatment.CONCLUSIONStage, histological characteristics, and response are independent risk factors in adults with malignant pineal parenchymal tumors. Late relapses are common.
Treatment of Chronic Pain with Spinal Cord Stimulation versus Alternative Therapies: Cost-effectiveness Analysis
Authors: Kumar Krishna , Malik Samaad , Demeria Denny 
Published: July 2004

Abstract

OBJECTIVE
There is limited available research measuring the cost-effectiveness of spinal cord stimulation (SCS), compared with best medical treatment/conventional pain therapy (CPT). The purpose of this study was to tabulate the actual costs (in Canadian dollars) for a consecutive series of patients treated with SCS in a constant health care delivery environment and to compare the costs with those for a control group treated in the same controlled environment.

METHODS
We present a consecutive series of 104 patients with failed back syndrome. Within this group, 60 patients underwent SCS electrode implantation, whereas 44 patients were designated as control subjects. We monitored these patients for a 5-year period and tabulated the actual costs incurred in diagnostic imaging, professional fees paid to physicians, implantation (including the costs for hardware), nursing visits for maintenance of the stimulators, physiotherapy, chiropractic treatments, massage therapy, and hospitalization for treatment of breakthrough pain. From these data, the cumulative costs for each group were calculated for a 5-year period. An analysis of Oswestry questionnaire results was also performed, to evaluate the effects of treatment on the quality of life.

RESULTS
The actual mean cumulative cost for SCS therapy for a 5-year period was $29,123/patient, compared with $38,029 for CPT. The cost of treatment for the SCS group was greater than that for the CPT group in the first 2.5 years. The costs of treating patients with SCS became less than those for CPT after that period and remained so during the rest of the follow-up period. In addition, 15% of SCS-treated patients were able to return to employment, because of superior pain control and lower drug intake. No patients in the control group were able to return to employment of any kind.

CONCLUSION
SCS is cost-effective in the long term, despite the initial high costs of the implantable devices.
Isolated, Giant Cerebellopontine Angle Craniopharyngioma in a Patient with Gardner Syndrome: Case Report
Authors: Link Michael J. , Driscoll Colin L.W. , Giannini Caterina 
Published: July 2004

Abstract

OBJECTIVE AND IMPORTANCE
We report the case of a 29-year-old man with Gardner syndrome and an isolated, giant cerebellopontine angle craniopharyngioma. Our description of this patient is only the second case report of a craniopharyngioma arising primarily in the cerebellopontine angle.

CLINICAL PRESENTATION
The patient presented with a 1-year history of progressive neurological impairment and headache. On the basis of the patient's history of multiple dermal fibromas, a cranial osteoma, familial adenomatous polyposis (FAP), a total abdominal colectomy, and an adenoma of the ampulla of Vater, we diagnosed the patient's condition as Gardner syndrome.

INTERVENTION
Magnetic resonance imaging showed a large cerebellopontine angle tumor, which was removed through a suboccipital retromastoid craniotomy. The pathological features were those of an adamantinomatous craniopharyngioma. The patient has done well postoperatively and has no new neurological deficits. A careful retrospective review of the preoperative imaging shows that this tumor was located exclusively in the posterior fossa and was not an extension of a sellar, suprasellar, or clival craniopharyngioma.

CONCLUSION
We present the second reported case of FAP and craniopharyngioma. There is no known genetic link between FAP and craniopharyngioma. Now that the patient has manifested a primary tumor of the central nervous system with FAP, it is unclear whether he should be classified as having Turcot syndrome. For this patient, we recommended vigilant follow-up imaging and forgoing external beam radiotherapy unless there is a documented recurrence of his craniopharyngioma.
Heterotopic Ossification of Peripheral Nerve (“Neuritis Ossificans”): Report of Two Cases
Authors: George David H. , Scheithauer Bernd W. , Spinner Robert J. , Buchler Ueli , Cronin Timothy E. , Reedy Michael T. , Arndt Byron C. 
Published: July 2004

Abstract

OBJECTIVE AND IMPORTANCE
Heterotopic ossification (“neuritis ossificans”) is among the least frequently encountered reactive lesions in peripheral nerves. Only two cases have been described previously, one in the median nerve of a 34-year-old man, and the other in the ulnar nerve of an adult woman. The architecture of this lesion is distinctly zonal. Consisting of a central fibroblastic core, an intervening zone of osteoid production, and a peripheral layer of ossification, the pattern is remarkably similar to that of myositis ossificans. This similarity and the occurrence of the process in superficial nerves have led to speculation that trauma plays a role in its pathogenesis; this hypothesis remains unproved. We describe two additional cases of neuritis ossificans.

CLINICAL PRESENTATION
One patient, a 41-year-old man, experienced pain and numbness in the left leg for several months but had no history of local trauma. A mass was detected in the saphenous nerve. The second patient, a 16-year-old boy, noted subacute onset of pain in the popliteal fossa and decreased sensation in the distribution of the lateral sural cutaneous nerve. A mass was found within the tibial nerve at the knee level.

INTERVENTION
In each patient, resection of the mass required sacrifice of a segment of the nerve.

CONCLUSION
In each patient, the mass was composed of fibrovascular tissue with osteoid and bone deposition arranged in a zonal pattern. The ossifying process was intraneural but encased rather than directly involving nerve fascicles. These exceptionally intact examples of neuritis ossificans underscore its resemblance to myositis ossificans. Nerve-sparing resection of such masses is not always possible.
Role of Frameless Stereotaxy in the Surgical Treatment of Cerebral Arteriovenous Malformations: Technique and Outcomes in a Controlled Study of 44 Consecutive Patients
Authors: Russell Stephen M. , Woo Henry H. , Joseffer Seth S. , Jafar Jafar J. 
Published: July 2004

Abstract

OBJECTIVE
To describe a frameless stereotactic technique used to resect cerebral arteriovenous malformations (AVMs) and to determine whether frameless stereotaxy during AVM resection could decrease operative times, minimize intraoperative blood losses, reduce postoperative complications, and improve surgical outcomes.

METHODS
Data for 44 consecutive patients with surgically resected cerebral AVMs were retrospectively reviewed. The first 22 patients underwent resection without stereotaxy (Group 1), whereas the next 22 patients underwent resection with the assistance of a frameless stereotaxy system (Group 2).

RESULTS
The patient characteristics, AVM morphological features, and percentages of preoperatively embolized cases were statistically similar for the two treatment groups. The mean operative time for Group 1 was 497 minutes, compared with 290 minutes for Group 2 (P = 0.0005). The estimated blood loss for Group 1 was 657 ml, compared with 311 ml for Group 2 (P = 0.0008). Complication rates, residual AVM incidences, and clinical outcomes were similar for the two groups.

CONCLUSION
Frameless stereotaxy allows surgeons to 1) plan the optimal trajectory to an AVM, 2) minimize the skin incision and craniotomy sizes, and 3) confirm the AVM margins and identify deep vascular components during resection. These benefits of stereotaxy were most apparent for small, deep AVMs that were not visible on the surface of the brain. Frameless stereotaxy reduces the operative time and blood loss during AVM resection.
Evaluation of Traumatic Cervical Nerve Root Injuries by Intraoperative Evoked Potentials
Authors: Oberle Joachim , Antoniadis Gregor , Kast Erich , Richter Hans-Peter 
Published: July 2004

Abstract

OBJECTIVE
To evaluate intraoperative evoked potentials as a diagnostic tool in traumatic brachial plexus injuries.

METHODS
Thirteen patients with traumatic brachial plexus injuries were investigated by intradural nerve root inspection (n = 28 roots) via cervical hemilaminectomy to assess or rule out nerve root avulsion from the spinal cord. Two to 8 weeks later, evoked potentials from neck and scalp were recorded after direct electrical nerve root stimulation close to the vertebral foramen during operative brachial plexus repair via an anterior (supraclavicular and infraclavicular) approach. Recordings were performed without and after full muscle relaxation.

RESULTS
There was a clear relationship between the state of the root as documented by intradural root inspection and the result of intraoperative recording of evoked potentials: the absence of evoked muscle action potentials from neck muscles demonstrated a 100% sensitivity for anterior root lesions, whereas sensory evoked potentials from the scalp demonstrated a 100% sensitivity for posterior root lesions. Moreover, roots could be identified with preserved continuity that did not conduct, suggesting a nerve lesion in continuity.

CONCLUSION
Intraoperative evoked muscle action potentials and sensory evoked potentials after electrical nerve root stimulation allow selective functional evaluation of anterior and posterior nerve roots in patients with traumatic brachial plexus injuries. The high sensitivity and reliability of this test obviate the need for additional diagnostic surgery.
Review: Complications of Minimally Invasive Spinal Surgery
Authors: Perez-Cruet Mick J. , Fessler Richard G. , Perin Noel I. 
Published: July 2004

AbstractCOMPLICATIONS OF MINIMALLY invasive spinal surgery can be related to anesthesia, patient positioning, and surgical technique. The performance of successful minimally invasive spinal surgery is beset with several technical challenges, including the limited tactile feedback, two-dimensional video image quality of three-dimensional anatomy, and the manual dexterity needed to manipulate instruments through small working channels, which all account for a very steep learning curve. Knowledge of possible complications associated with particular minimally invasive spinal procedures can aid in their avoidance. This article reviews complications associated with minimally invasive spinal surgery in the cervical, thoracic, and lumbar spine by reviewing reported data of sufficient detail or with sufficient numbers of patients. In addition, possible complications associated with anesthesia use, patient positioning, and surgical techniques during thoracoscopic and laparoscopic spinal procedures are reviewed.
Anterior Cervical Microforaminotomy for Spondylotic Cervical Myelopathy: Part 2
Authors: Jho Hae-Dong , Kim Myung-Hyun , Kim Woo-Kyung 
Published: July 2004

Abstract

OBJECTIVE
Anterior microforaminotomy for spondylotic cervical myelopathy is reported with surgical results.

METHODS
A retrospective study was performed for 40 patients with spondylotic cervical myelopathy who had been surgically treated with anterior microforaminotomy at the University of Pittsburgh between April 1994 and June 1999. Age ranged from 32 to 74 years (median, 51 yr). Twenty-eight patients were men, and 12 were women. All had undergone magnetic resonance imaging (MRI) scans preoperatively. All underwent MRI scans and dynamic roentgenograms 6 weeks after the operation. The duration of follow-up ranged from 24 months to 86 months (median, 42 mo).

RESULTS
Twenty-eight patients (70%) had radiculopathy in addition to their myelopathy. Single-level operations were performed in 13 patients (32.5%), two-level operations in 19 patients (47.5%), three-level operations in 5 patients (12.5%), and four-level operations in 3 patients. Eleven patients (27.5%) had excellent results, 21 patients (52.5%) had good results, and 8 patients (20%) had unchanged results 6 weeks after the operation. Thirty-five patients (87.5%) were discharged the day of or the day after their operation. In all patients, MRI scans revealed good anatomic decompression, and dynamic roentgenograms revealed good stability. Postoperative complications included temporary deltoid weakness in one patient and temporary voice fatigue in another patient. In a final survey of 30 patients, 16 patients (53.3%) experienced excellent results, 11 patients (36.6%) experienced good results, and 3 patients (10%) experienced unchanged results. Final outcome survey with modified Japanese Orthopedic Association score is reported in 25 patients.

CONCLUSION
Anterior microforaminotomy provided good to excellent surgical results in 80% of the patients with minimal morbidities 6 weeks after the operation and in 90% of the patients at long-term follow-up. Spinal stability was well maintained in all patients.
Thoracic, Lumbar, and Sacral Spine Anatomy for Endoscopic Surgery
Authors: Pait T. Glenn , Elias Alexandre J.R. , Tribell Ron 
Published: July 2004

Abstract
WE DISCUSS THE anatomy of the thoracic, lumbar, and sacral levels of the spinal cord. Given the nature of endoscopic surgery, it is recommended that the surgeon have thorough knowledge not only of the bony architecture but also of important visceral and other soft tissue structures. It is essential to understand the normal anatomy to recognize the abnormal and anatomic variations. We present the so-called normal anatomic configurations and illustrate how these structures vary at the different levels of the spinal column.
Predictors of Successful Outcome for Lumbar Chemonucleolysis: Analysis of 3000 Cases during the Past 14 Years
Authors: Kim Young-Soo , Chin Dong-Kyu , Cho Yong-Eun , Jin Byung-Ho , Yoon Do-Heum 
Published: July 2004

AbstractOBJECTIVEAmong numerous minimally invasive procedures for the treatment of herniated lumbar disc disease (HLD), chymopapain chemonucleolysis has the longest history of clinical usage. Long-term studies indicated good clinical results with a low risk for patients. However, much confusion still remains about the indications. This study was conducted to evaluate the predictors of successful outcome for chemonucleolysis and to firmly establish the proper indications for this procedure.METHODSThree thousand patients with HLD were treated with chemonucleolysis between 1984 and 1999. The clinical success rate in our series was 85%. The medical history and physical and radiological findings, including the type and direction of disc herniation, were analyzed retrospectively.RESULTSThe patient group with the chief complaint of leg pain achieved a better clinical outcome than the patient group with low back pain (88% versus 59%, P &lt; 0.05). A positive straight-leg-raising test was strongly correlated with good clinical outcome (&lt; P &lt; 0.05). Patients manifesting a soft, protruded disc had a better outcome than those manifesting diffuse bulging disc (&lt; P &lt; 0.05). Other prognostic factors favoring a good outcome were as follows: young age, short duration of symptoms, and no bony spur or calcification on radiological study.CONCLUSIONChymopapain chemonucleolysis is a safe and effective procedure. Proper selection of patients is important for the success of treatment. We propose the following three clinical criteria (Kim's triad) for selection of patients: chief complaint of leg pain rather than back pain, positive straight-leg-raising test, and soft protruded disc.
Microendoscopic Lumbar Discectomy: Technical Note
Authors: Perez-Cruet Mick J. , Foley Kevin T. , Isaacs Robert E. , Rice-Wyllie Lauri , Wellington Robin , Smith Maurice M. , Fessler Richard G. 
Published: July 2004

Abstract

OBJECTIVE
The microendoscopic discectomy (MED) technique was initially developed in 1997 to treat herniated lumbar disc disease. Since then, thousands of cases have been successfully performed at more than 500 institutions. This article discusses the technical aspects of this procedure and presents a consecutive case series.

METHODS
A total of 150 consecutive patients underwent MED. MED is performed by a muscle-splitting approach using a series of tubular dilators with consecutively increasing diameters. A tubular retractor is then inserted over the final dilator, and a specially designed endoscope is placed inside the tubular retractor. The microdiscectomy is performed endoscopically while the surgeon views the procedure on a video monitor.

RESULTS
Clinical outcomes were determined using a modified MacNab criteria, which revealed that 77% of patients had excellent, 17% had good, 3% had fair, and 3% had poor outcomes. The average hospital stay was 7.7 hours. The average return to work period was 17 days. Complications primarily included dural tears, which occurred in 8 patients (5%) and were seen early on in the patient series. Complication rates diminished as the surgeon's experience with this technique increased.

CONCLUSION
MED for lumbar herniated disc disease can be performed safely and effectively, resulting in a shortened hospital stay and faster return to work; however, there is a learning curve to this procedure.
Microsurgical Anterior Approaches to the Lumbar Spine for Interbody Fusion and Total Disc Replacement
Authors: Mayer H. Michael , Wiechert Karsten 
Published: July 2004

AbstractOBJECTIVEAnterior approaches to the lumbar spine for the treatment of various degenerative or postoperative abnormalities associated with low back pain have always been a matter of debate. They are known to be associated with considerable surgical trauma, high postoperative morbidity, and, occasionally, unacceptably high complication rates. In 1997, we inaugurated two new microsurgical modifications of conventional anterior approach techniques, which have been applied in anterior lumbar interbody fusion and more recently in total disc replacement. This article describes the results of microsurgical anterior interbody fusion in a consecutive series of 171 patients as well as preliminary results of these techniques for total disc replacement in 26 patients.METHODSThe approaches are performed with the use of a surgical microscope. Lumbar segments L2–L5 are exposed through a lateral retroperitoneal approach. L5–S1 can be reached through a midline retroperitoneal or transperitoneal approach. Both approaches can be performed through a limited skin incision of 4 cm.RESULTSAn independent observer evaluated results of anterior lumbar interbody fusion in 171 patients during a 2-year follow-up period. The clinical follow-up demonstrated low perioperative and postoperative morbidity with an average blood loss of less than 100 ml at the fusion site. Pseudoarthrosis rates were less than 5%, and clinical results, as evaluated in accordance with the scoring system developed by Prolo et al., did not differ significantly from conventional open techniques. Total disc replacement through a microsurgical anterior approach seems to be a promising alternative to fusion procedures with even less intraoperative and perioperative morbidity.CONCLUSIONMicrosurgical anterior approaches to the lumbar spine provide a reasonable surgical alternative to conventional approaches for anterior interbody fusion and total disc replacement.