bluuebunny/crossref_metadata_2025_split huggingface dataset:
#98 : Autologous Platelet-Rich Plasma Administration’s Efficacy in Patients with Low Ovarian Reserve: A Systematic Review and Meta-Analysis
Authors: Sa’diah Yasmin Sabina , Dewanto Agung , Chandra Lukman Ade 
Published: January 2024

Background and Aims: Autologous platelet-rich plasma (PRP) as a novel therapeutic approach has been utilized in multiple aspects of medicine because it contains stem cells and growth factors. There is still controversy over the effectiveness of this strategy in managing infertile women with low ovarian reserve due to the lack of evidence-based studies. This study aimed to systematically investigate and meta-analyze the best available evidence from clinical trials evaluating the impact of autologous platelet-rich plasma on low ovarian reserve. Methods: Systematic searches in electronic databases including PubMed, Cochrane, and Google Scholar use relevant search terms. We included infertile women with low ovarian reserve in single-arm clinical trials. Ovarian reserve parameters were measured before and after PRP injection into the ovaries. Data were extracted from each eligible study, then pooled (meta-analysis). The risk of bias (RoB) was evaluated using RoB 2 assessment tools. Results: Three hundred and one articles were collected and excluded, leaving six eligible studies, then classified into two subgroups: poor ovarian response (POR) and primary ovarian insufficiency (POI). Following PRP injection, infertile women showed an improvement in ovarian reserve. There was a significant increase in anti-Mullerian hormone (AMH) level (MD = 0.12, 95% CI [0.005; 0.23], I2=99%, subgroup differences p=0.33), a significant increase in antral follicle count (AFC) (MD = 1.88, 95% CI [0.86; 2.89], I2=93%, subgroup differences p=0.67), with a non-significant reduction in follicle-stimulating hormone (FSH) level (MD = 0.32, 95% CI [0.18; 0.46], I2=94%, subgroup differences p=0.02). According to the RoB’s assessment, the original research studies’ overall quality was a low risk of bias. Conclusions: Autologous platelet-rich plasma may increase AMH and AFC, but not FSH. Although it was discovered beneficial in enhancing ovarian reserve and effective for ovarian rejuvenation, further research with a large number of samples and strong evidence is still required.
#300 : Prevalence of Vitamin D Insufficiency in Women of Reproductive Age in Singapore
Authors: Tan Shu Qi 
Published: January 2024

Background and Aims: Vitamin D is known to play an essential role in bone and mineral metabolism. There have been more studies reporting the association of low vitamin D levels with fertility problems and undesirable pregnancy outcomes. Guidelines have recommended Vitamin D supplementation in pregnancy. However, this is still not routine in our local practice. Our study aims to assess the Vitamin D levels in pregnant women in their first trimester, to establish the need for Vitamin D supplementation in our population. Method: A prospective cohort study was performed at the antenatal outpatient clinic of the largest obstetric centre in Singapore between October 2020 to April 2021. 5 ml was blood was collected and a standard asset of 25-hydroxyvitamin D levels was performed on pregnant women at their antenatal booking visit. They were stratified into sufficient, insufficient, moderately deficient, and severely deficient. Results: A total of 93 women participated in our study. Only 2.2% of this study population had sufficient Vitamin D levels. In women who had insufficient Vitamin D levels, it was inversely co-related to their body-mass-index (BMI). Interestingly, the older the women, the less likely they were likely to be Vitamin D deficient. In women with peri-conceptual multivitamin supplementation, the average Vitamin D levels for those with supplementation was 2.1ng/ml higher that those without supplementation. This study period coincided with COVID-19 pandemic, who could impact on the outdoor activity duration in our study population. Conclusion: Vitamin D levels are generally low in our local women of reproductive age group. The role of routine testing of Vitamin D levels with an aim for supplementation should be considered.
#117 : Survey of Transitional Care in Patients with Pediatric Cancer
Authors: Nakamura Kentaro , Terashita Yukayo , Ito Kaoru , Suzuki Yuki , Iwahata Hideyuki , Sugishita Yodo , Horage Yuki , Takae Seido , Manabe Atsushi , Suzuki Nao 
Published: January 2024

Background and Aims: Childhood and adolescent cancer survivors often require a long period of follow-up, carrying health risks even after overcoming cancer, and it is desirable for them to shift departments as they grow physically. In this study, we aimed to survey obstetricians and gynecologists about the actual situation regarding transitional care for patients with pediatric cancer (PPCs) in Japan. Method: We conducted a questionnaire survey on transitional care from January 2021 to March 2022, targeting 579 training facilities registered with the Japanese Society of Obstetrics and Gynecology. This work was supported by MHLW Research for Promotion of Cancer Control Program Grant No. JPMH20EA1004. Results: The total response rate was 58.5%. When asked “if they provide transitional care specifically for PPCs between pediatrics and obstetrics/gynecology”, only 13% responded that they do. Forty percent had received referrals for PPCs. The most common reasons for referral were “irregular menstruation or irregular genital bleeding” and “suspected ovarian dysfunction”. The most common problems with referrals from pediatrics were related to “insufficient explanation” in many cases. In addition, at facilities with no experience in treating PPCs, many respondents commented that they didn’t know how to follow up on the progress of the disease. When asked “about the necessity of obstetrics/gynecology visits for PPCs”, more than half of the facilities with experience in treating PPCs answered that such visits were “necessary”, and only 1% answered that they were “unnecessary”. On the other hand, 37% of the facilities that had no experience in treating PPCs answered that it was “necessary”, and 4% answered that it was “unnecessary”. Conclusion: The results suggest that what needs to be done in the future is to educate healthcare professionals by providing them with knowledge, as well as patient education that leads to patients’ awareness of their own self-management.
#361 : What Does My Embryo Score Mean? The Relationship Between KIDScore, Life Whisperer AI Score, and Embryo Euploidy
Authors: Soo Ying-Chen , Tian Tee Sze , Heong Chee San , Lim Ee Leen , Yong Kai Boon 
Published: January 2024

Background and Aims: Many models have been developed for predicting an embryo’s euploidy or implantation potential. These models assign continuous scores to embryos, based on annotation performed by embryologists according to morphokinetic parameters, or based on deep learning analysis of embryo images or video, with higher scores indicating higher probability of implantation and/or euploidy. However, the actual probability of implantation or euploidy at a given score is not always clear. We aimed to investigate the relationship between scores assigned by an annotation model (KIDScoreD5 v3.1, Vitrolife), an image analysis model (Life Whisperer, Presagen), and embryo euploidy. Method: From January 2019 to May 2021, PGT-A by NGS performed on blastocysts in Thomson Hospital Kota Damansara in Malaysia identified 273 euploid and 212 aneuploid blastocysts. Since blastocyst culture in a timelapse incubator (Embryoscope+, Vitrolife) is routine in our centre, the KIDScore for each blastocyst was known. Still image data of the same embryos was uploaded to the Life Whisperer (LW) platform. Embryos were grouped based on their KIDScore and LW score, and the percentage of euploid and aneuploid embryos in each group was calculated. Results: In both models, there were more embryos in higher score groups, as only embryos with good morphology underwent PGT-A (Figures 1 and 2). In KIDScore groups up to score 8, approximately 50% of embryos were euploid, while in KIDScore groups >8-9 and >9-10, 76.6% and 75.5% of embryos were euploid respectively (Figure 1). In LW groups up to score 7, approximately 50% of embryos were euploid, while in LW groups >7-8, >8-9, and >9-10, the percentage increased to 56.1%, 58.6%, and 66.7% respectively (Figure 2). Conclusion: Increasing KIDScores and LW scores correspond with increased percentages of euploid embryos. However, the increase is not constant, especially for KIDScores. These results can be used to estimate the probability of euploidy at a given embryo score.
#298 : Congenital Anomalies in Children Born after Assisted Reproduction in the Czech Republic
Authors: Sipek Antonin , Gregor Vladimir , Sipek Antonin , Klaschka Jan , Maly Marek 
Published: January 2024

Background and Aims: The number of children conceived by assisted reproduction techniques (ART) is increasing in the Czech Republic. However, several studies reported an increased incidence of congenital anomalies in ART-conceived children. The main goal of this study was to evaluate this theoretical risk using population-based data from Czech medical registries. Method: The retrospective epidemiological analysis was performed using data from the National Registry of Congenital Anomalies and the National Registry of Newborns, run by the Institute of Health Information and Statistics of the Czech Republic. All diagnoses of congenital anomalies (Q00-Q99) were included. The registration process is population-wide and compulsory by Czech law. We compared the incidences of congenital anomalies in naturally conceived children and ART-conceived children born in the Czech Republic for 8 years period (2013–2020). Statistical analysis was performed by Fisher’s exact test. Results: In our study, we demonstrated a higher incidence of congenital anomalies in the children born after ART (4.35%) compared to the incidence in the group of children born after spontaneous conception (3.90%). This difference was statically significant (p < 0.05). In the group of children born after ART, congenital defects of the central nervous system, congenital heart defects, and congenital defects of the gastrointestinal tract were diagnosed more frequently. In some groups of congenital defects, a higher proportion of males compared to females and a higher representation of cases with a congenital defect in children born from multiple pregnancies were also found. Conclusion: The results from our population-based study confirm that the incidence of selected groups of congenital anomalies may be higher in children born after ART.
#372 : Spontaneous Hemoperitoneum in an Advanced Intracytoplasmic Sperm Injection In-Vitro Fertilization Conceived Pregnancy
Authors: Ibonia Kristine Andrea , Cabling Ma. 
Published: January 2024

A 38-year-old primigravid, six years infertile, conceived a dichorionic-diamnionic twin gestation by intracytoplasmic sperm injection and in vitro fertilization. At 33 weeks gestation, she was admitted, due to a sudden excruciating abdominal pain with profuse vaginal bleeding. Abruptio placenta was suspected and emergency cesarean section was done revealing massive hemoperitoneum. The babies were delivered first. On further inspection, actively bleeding, coalesced, friable pinkish blebs with a pulsating, bleeding vessel were seen at the left posteromidlateral corpus. Pinkish blebs were also seen occupying the right posterior area. Bilateral uterine artery ligation and repair of the bleeding site were done. Postoperative course was stable and she was discharged after 6 days. Sudden, severe abdominal pain in late pregnancy has numerous causes. Intraoperative findings seen in this case, is a condition known as Spontaneous Hemoperitoneum in Pregnancy (SHiP). SHiP is a rare disorder associated with unprovoked peritoneal bleeding reported to occur during the second half of pregnancy, in labor, or early postpartum. Its diagnosis is rarely made before laparotomy and surgery is often due to a preoperative diagnosis of abruptio placenta. Etiology of SHiP remains unknown but is particularly relevant in women with endometriosis and deciduosis. Deciduosis is believed to be a physiologic phenomenon of pregnancy that would spontaneously involute after delivery. It generally has no clinical symptoms but may present pathologic conditions such hemoperitoneum. In this patient, hemoperitoneum was caused by rupture of utero-ovarian vessels or bleeding endometriotic implants believed to be related to progesterone resistance manifested by selective molecular abnormalities causing aberrant decidualization of stromal cells of the ectopic endometrium leading to bleeding of unpredictable severity. This case illustrates the surgical challenge of controlling bleeding from multiple decidualized lesions and eroded blood vessels. Fortunately, both the mother and the babies were saved by early detection and immediate intervention.
Map Matching Queries on Realistic Input Graphs Under the Fréchet Distance
Authors: Gudmundsson Joachim , Seybold Martin P. , Wong Sampson 
Published: January 2024

Map matching is a common preprocessing step for analysing vehicle trajectories. In the theory community, the most popular approach for map matching is to compute a path on the road network that is the most spatially similar to the trajectory, where spatial similarity is measured using the Fréchet distance. A shortcoming of existing map matching algorithms under the Fréchet distance is that every time a trajectory is matched, the entire road network needs to be reprocessed from scratch. An open problem is whether one can preprocess the road network into a data structure, so that map matching queries can be answered in sublinear time.

In this article, we investigate map matching queries under the Fréchet distance. We provide a negative result for geometric planar graphs. We show that, unless SETH fails, there is no data structure that can be constructed in polynomial time that answers map matching queries in
O((pq)
1-δ
) query time for any δ > 0, where
p
and
q
are the complexities of the geometric planar graph and the query trajectory, respectively. We provide a positive result for realistic input graphs, which we regard as the main result of this article. We show that for
c
-packed graphs, one can construct a data structure of

\(\tilde{O}(cp)\)

size that can answer (1+ε)-approximate map matching queries in

\(\tilde{O}(c^4 q \log ^4 p)\)

time, where

\(\tilde{O}(\cdot)\)

hides lower-order factors and dependence on ε.
Preeclampsia-Associated Cardiovascular Risk Factors 6 Months and 2 Years After Pregnancy: The P4 Study
Authors: Henry Amanda , Mangos George , Roberts Lynne M. , Brown Mark A. , Pettit Franziska , O’Sullivan Anthony J. , Crowley Rose , Youssef George , Davis Gregory K. 
Published: January 2024

BACKGROUND:
Increased cardiovascular risk following preeclampsia is well established and there are signs of early cardiovascular aging 6 months postpartum. This study assessed whether blood pressure (BP) and other cardiovascular measures are abnormal 2 years postpartum in the same cohort to determine ongoing risk markers.

METHODS:
Six months and 2 years postpartum, BP was measured using sphygmomanometry, 24-hour ambulatory BP monitoring, and noninvasive central BP. Anthropometric measures, blood, and urine biochemistry were performed. Cross-sectional comparisons between preeclampsia and normotensive pregnancy (NP) groups and longitudinal comparisons within each group were made at 6 months and 2 years.

RESULTS:

Two years postpartum, 129 NP, and 52 preeclampsia women were studied who also had 6 months measures. At both time points, preeclampsia group had significantly higher BP (office BP 2 years, 112±12/72±8 versus 104±9/67±7 mm Hg NP; [
P
<0.001]; mean ambulatory BP monitoring 116±9/73±8 versus 106±8/67±6 mm Hg NP; [
P
<0.001]). No significant BP changes noted 6 months to 2 years within either group. Office BP thresholds of 140 mm Hg systolic and 90 mm Hg diastolic classified 2% preeclampsia and 0% NP at 2 years. American Heart Association 2017 criteria (above normal, >120/80 mm Hg) classified 25% versus 8% (
P
<0.002), as did our reference range threshold of 122/79 mm Hg. American Heart Association criteria classified 60% post-preeclampsia versus 16% after NP with above-normal ambulatory BP monitoring (
P
<0.001). Other cardiovascular risk markers more common 2 years post-preeclampsia included higher body mass index (median 26.6 versus 23.1,
P
=0.003) and insulin resistance.

CONCLUSIONS:
After preeclampsia, women have significantly higher BP 6 months and 2 years postpartum, and have higher body mass index and insulin-resistance scores, increasing their future cardiovascular risk. Regular cardiovascular risk screening should be implemented for all who have experienced preeclampsia.
Parabiosis Discriminates the Circulating, Endothelial, and Parenchymal Contributions of Endogenous Tissue-Type Plasminogen Activator to Stroke
Authors: Furon Jonathane , Lebrun Florent , Yétim Mervé , Levard Damien , Marie Pauline , Orset Cyrille , Martinez de Lizarrondo Sara , Vivien Denis , Ali Carine 
Published: January 2024

BACKGROUND:
Intravenous injection of alteplase, a recombinant tPA (tissue-type plasminogen activator) as a thrombolytic agent has revolutionized ischemic stroke management. However, tPA is a more complex enzyme than expected, being for instance able to promote thrombolysis, but at the same time, also able to influence neuronal survival and to affect the integrity of the blood-brain barrier. Accordingly, the respective impact of endogenous tPA expressed/present in the brain parenchyma versus in the circulation during stroke remains debated.

METHODS:

To address this issue, we used mice with constitutive deletion of tPA (tPA
Null
[tPA-deficient mice]) or conditional deletion of endothelial tPA (VECad [vascular endothelial-Cadherin-Cre-recombinase]-Cre
∆tPA
). We also developed parabioses between tPA
Null
and wild-type mice (tPA
WT
), anticipating that a tPA
WT
donor would restore levels of tPA to normal ones, in the circulation but not in the brain parenchyma of a tPA
Null
recipient. Stroke outcomes were investigated by magnetic resonance imaging in a thrombo-embolic or a thrombotic stroke model, induced by local thrombin injection or FeCl
3
application on the endothelium, respectively.

RESULTS:

First, our data show that endothelial tPA, released into the circulation after stroke onset, plays an overall beneficial role following thrombo-embolic stroke. Accordingly, after 24 hours, tPA
Null
/tPA
Null
parabionts displayed less spontaneous recanalization and reperfusion and larger infarcts compared with tPA
WT
/tPA
WT
littermates. However, when associated to tPA
WT
littermates, tPA
Null
mice had similar perfusion deficits, but less severe brain infarcts. In the thrombotic stroke model, homo- and hetero-typic parabionts did not differ in the extent of brain damages and did not differentially recanalize and reperfuse.

CONCLUSIONS:
Together, our data reveal that during thromboembolic stroke, endogenous circulating tPA from endothelial cells sustains a spontaneous recanalization and reperfusion of the tissue, thus, limiting the extension of ischemic lesions. In this context, the impact of endogenous parenchymal tPA is limited.
The molecular mechanisms underlying gut microbiota-miRNA interaction in metabolic disorders
Authors: Prukpitikul P. , Sirivarasai J. , Sutjarit N. 
Published: January 2024

Abstract
Metabolic disorders are a major global health problem. Gut microbiota not only affect host metabolism through metabolites, inflammatory processes, and microbial-derived extracellular vesicles, but they also modulate the host microRNA, which may impact the host metabolism. Hence, the underlying mechanisms between gut microbiota-microRNA interaction can potentially be a novel alternative strategy for treating metabolic disorders. This review aims to give an update on the latest evidence and current knowledge of the underlying mechanisms of gut microbiota-miRNA interaction, focusing on metabolic homeostasis. Gut microbiota mainly communicate with host microRNA through lipopolysaccharide and secondary microbial metabolites. These signalling messengers circulate around the metabolic organs and modify gene expression through microRNA interference. Interestingly, while intestinal microRNAs play a vital role in both intestinal barrier and gut microbiota homeostasis, the presence of gut microbiota is also required for the proper functioning of intestinal microRNAs, suggesting a cooperative mechanism in intestinal health. Although the correlations between gut microbiota and microRNA have been observed in both mice and humans, a causal relationship should be confirmed. Moreover, further investigation is needed to provide more evidence of a gut microbiota-microRNA interaction to support the possibility of using that axis as a novel therapeutic target to treat metabolic disorders.
The Folly of Deception: Proverbs 26:24–28, Falsification of Results, and the National University Commission in Nigeria
Authors: Uroko Favour C. 
Published: January 2024

Abstract
This study is a theological reflection on Proverbs 26:24–28 and its relevance to the National Universities Commission’s accreditation exercises in Nigerian universities. Existing literature has not adequately looked into the corruption going on between the nuc and universities in Nigeria. In this study, we extended the literature in this area. The nuc usually earmarks periods to visit universities to appraise their infrastructure and manpower capacity. The aim was to ensure that funding for Nigerian universities was judiciously used. Unfortunately, when nuc officials visit universities, they are bribed into writing down in their reports the pass mark for departments and units that are not qualified to have a pass mark. Also, lectures and departmental heads go as far as borrowing classrooms and offices and putting up tags just to escape the accreditation process. This has greatly added to the sorry state of Nigerian universities. A literary analysis was employed. Recommendations were proffered.
Comparative simulation of intraperitoneal aminoglycoside regimens for patients with peritonitis on automated peritoneal dialysis
Authors: Ariano Robert E , Zelenitsky Sheryl A , Davis Christine , Sathianathan Christie , Wolowich William R 
Published: January 2024

Background: Intraperitoneal (IP) aminoglycosides (AGs) continue to be the cornerstone of empiric management of peritonitis. AG dosing during automated peritoneal dialysis (APD), however, has not been well studied in patients with peritonitis. We sought to identify differences in AG exposure in the peritoneum and plasma for two different dosing regimens with little supporting evidence in patients on APD with peritonitis. Methods: A retrospective design that utilised the peritoneal and plasma concentration–time data from a prior study of 18 continuous ambulatory peritoneal dialysis (CAPD) patients with peritonitis to generate an in silico peritoneal and plasma PK model. This model was then used to compare via simulation using Phoenix© WinNonlin Software with IP AG dosing for a loading-dose regimen (1.5 mg/kg first dose) versus a fixed-dose regimen (0.6 mg/kg/d) in patients on APD with peritonitis. Results: Outcome measures were (1) percentage of time where peritoneal peak concentrations/minimal inhibitory concentration (MIC) ratio >10, (2) AUC/MIC > 74 and (3) plasma Cmin concentrations. Both regimens resulted in > 90% optimal peak/MIC ratio and AUC/MIC ratios on days 1 and 5 of the dose protocol. The loading-dose regimen resulted in IP exposures that were 2.5 times greater in the peritoneal compartment on day 1. By day 5, both protocols resulted in similar accumulation of AG plasma Cmin concentrations of 2.5–3.4 mg/L versus 2.4–3.3 mg/L, respectively, for the loading-dose regimen versus fixed-dose regimen. Conclusions: The current international guidelines for the treatment of peritoneal dialysis-associated peritonitis can continue to recommend the fixed-dose regimen for those on APD with the addition of plasma Cmin monitoring after 3 days to assess for drug accumulation.