bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Metode User Centered Design Pada Perancangan Website Evidence File Kegiatan Dinas Kesehatan Provinsi Sumatera Selatan
Authors: Perdani Tharisa Antya , Ruskan Endang Lestari , Meiriza Allsela 
Published: November 2023

Saat ini hampir di semua kegiatan pemerintah maupun non pemerintah telah memanfaatkan teknologi informasi, salah satu contohnya adalah sistem penyimpanan data kegiatan. Tidak hanya memerhatikan fungsionalitas dari sebuah sistem, akan tetapi tampilan juga termasuk ke dalam aspek penting yang sering kali terjadi masalah di bagian tersebut. Pada pengelolaan data evidence file aktivitas di Dinas Kesehatan Provinsi Sumatera Selatan saat ini menggunakan Google Drive yang memiliki masalah terkait tampilan. Pada Google Drive tidak bisa memberikan input keterangan atau caption tentang file kegiatan yang dilaksanakan, karena Google Drive hanya menyimpan gambar, pdf, doc, dan lainnya. Selain itu, Google Drive dapat diakses oleh banyak orang yang mengakibatkan layout tampilan bisa berubah-ubah. Maka, membutuhkan suatu strategi terkhusus dalam membuat sistem terkomputerisasi secara otomatis dalam mengelola evidence file, dengan merancang tampilan yang sesuai keinginan pengguna dari sisi layout menu file menerapkan metode User Centered Design (UCD). Hasilnya berupa prototype website evidence file kegiatan. Evaluasinya menggunakan metode System Usability Scale guna mengetahui nilai kegunaan rancangan yang dibuat. Hasil yang diperoleh adalah 82. Skor ini dikatergorikan “Excellent”, grade scale B, dan tingkat penerimaannya “Accaptable” yang artinya dapat diterima sesuai dengan keinginan user dan layak untuk dikembangkan.
Polymeric reinforcements for cellularized collagen-based vascular wall models: influence of the scaffold architecture on the mechanical and biological properties
Authors: Pien Nele , Di Francesco Dalila , Copes Francesco , Bartolf-Kopp Michael , Chausse Victor , Meeremans Marguerite , Pegueroles Marta , Jüngst Tomasz , De Schauwer Catharina , Boccafoschi Francesca , Dubruel Peter , Van Vlierberghe Sandra , Mantovani Diego 
Published: November 2023

A previously developed cellularized collagen-based vascular wall model showed promising results in mimicking the biological properties of a native vessel but lacked appropriate mechanical properties. In this work, we aim to improve this collagen-based model by reinforcing it using a tubular polymeric (reinforcement) scaffold. The polymeric reinforcements were fabricated exploiting commercial poly (ε-caprolactone) (PCL), a polymer already used to fabricate other FDA-approved and commercially available devices serving medical applications, through 1) solution electrospinning (SES), 2) 3D printing (3DP) and 3) melt electrowriting (MEW). The non-reinforced cellularized collagen-based model was used as a reference (COL). The effect of the scaffold’s architecture on the resulting mechanical and biological properties of the reinforced collagen-based model were evaluated. SEM imaging showed the differences in scaffolds’ architecture (fiber alignment, fiber diameter and pore size) at both the micro- and the macrolevel. The polymeric scaffold led to significantly improved mechanical properties for the reinforced collagen-based model (initial elastic moduli of 382.05 ± 132.01 kPa, 100.59 ± 31.15 kPa and 245.78 ± 33.54 kPa, respectively for SES, 3DP and MEW at day 7 of maturation) compared to the non-reinforced collagen-based model (16.63 ± 5.69 kPa). Moreover, on day 7, the developed collagen gels showed stresses (for strains between 20% and 55%) in the range of [5–15] kPa for COL, [80–350] kPa for SES, [20–70] kPa for 3DP and [100–190] kPa for MEW. In addition to the effect on the resulting mechanical properties, the polymeric tubes’ architecture influenced cell behavior, in terms of proliferation and attachment, along with collagen gel compaction and extracellular matrix protein expression. The MEW reinforcement resulted in a collagen gel compaction similar to the COL reference, whereas 3DP and SES led to thinner and longer collagen gels. Overall, it can be concluded that 1) the selected processing technique influences the scaffolds’ architecture, which in turn influences the resulting mechanical and biological properties, and 2) the incorporation of a polymeric reinforcement leads to mechanical properties closely matching those of native arteries.
Is it reasonable to shorten the length of cemented stems? A finite element analysis and biomechanical experiment
Authors: Li Junyan , Xiong Liang , Lei Chao , Wu Xinyu , Mao Xinzhan 
Published: November 2023

Background: Uncemented short stems have been shown to optimize load distribution on the proximal femur, reducing stress shielding and preserving bone mass. However, they may adversely affect the initial stability of the stems. To date, most research conducted on short stems has predominantly centered on uncemented stems, leaving a notable dearth of investigations encompassing cemented stems. Therefore, this study aimed to investigate the length of cemented stems on the transmission of femoral load patterns and assess the initial stability of cemented short stems.Method: A series of finite element models were created by gradient truncation on identical cemented stem. The impact of varying lengths of the cemented stem on both the peak stress of the femur and the stress distribution in the proximal femur (specifically Gruen zones 1 and 7) were assessed. In addition, an experimental biomechanical model for cemented short stem was established, and the initial stability was measured by evaluating the axial irreversible displacement of the stem relative to the cement.Result: The maximum von-Mises stress of the femur was 58.170 MPa. Spearman correlation analysis on the shortened length and von-Mises stress of all nodes in each region showed that the p-values for all regions were less than 0.0001, and the correlation coefficients (r) for each region were 0.092 (Gruen Zone 1) and 0.366 (Gruen Zone 7). The result of the biomechanical experiment showed that the irreversible axial displacement of the stem relative to cement was −870 μm (SD 430 μm).Conclusion: Reducing the length of a cemented stem can effectively enhance the proximal load of the femur without posing additional fracture risk. Moreover, the biomechanical experiment demonstrated favorable initial stabilities of cemented short stems.
Joint 2D–3D cross-pseudo supervision for carotid vessel wall segmentation
Authors: Zhou Yahan , Yang Lin , Guo Yuan , Xu Jing , Li Yutong , Cai Yongjiang , Duan Yuping 
Published: November 2023

IntroductionThe segmentation of the carotid vessel wall using black-blood magnetic resonance images was a crucial step in the diagnosis of atherosclerosis. The objective was to accurately isolate the region between the artery lumen and outer wall. Although supervised learning methods achieved remarkable accuracy in vessel segmentation, their effectiveness remained limited due to their reliance on extensive labeled data and human intervention. Furthermore, when confronted with three-dimensional datasets featuring insufficient and discontinuous label data, these learning-based approaches could lose their efficacy. In this paper, we proposed a novel Joint 2D–3D Cross-Pseudo Supervision (JCPS) method for accurate carotid vessel wall segmentation.MethodsIn this study, a vascular center-of-gravity positioning module was developed to automatically estimate the region of blood vessels. To achieve accurate segmentation, we proposed a joint 2D–3D semi-supervised network to model the three-dimensional continuity of vascular structure. In addition, a novel loss function tailored for vessel segmentation was introduced, consisting of four components: supervision loss, cross-pseudo supervision loss, pseudo label supervision loss, and continuous supervision loss, all aimed at ensuring the accuracy and continuity of the vessel structure. In what followed, we also built up a user-friendly Graphical User Interface based on our JCPS method for end-users.ResultsOur proposed JCPS method was evaluated using the Carotid Artery Vessel Wall Segmentation Challenge dataset to assess its performance. The experimental results clearly indicated that our approach surpassed the top 10 methods on the leaderboard, resulting in a significant enhancement in segmentation accuracy. Specifically, we achieved an average Dice similarity coefficient increase from 0.775 to 0.806 and an average quantitative score improvement from 0.837 to 0.850, demonstrating the effectiveness of our proposed JCPS method for carotid artery vessel wall segmentation.ConclusionThe experimental results suggested that the JCPS method had a high level of generalization performance by producing pseudo labels that were comparable with software annotations for data-imbalanced segmentation tasks.
Association between serum complements and kidney function in patients with diabetic kidney disease
Authors: Liu Meng-chao , Li Jia-lin , Wang Yue-fen , Meng Yuan , Zheng Gui-min , Cai Zhen , Shen Cun , Wang Meng-di , Zhu Xiang-gang , Chen Yang-zi , Wang Yu-lin , Zhao Wen-jing , Niu Wen-quan , Wang Yao-xian 
Published: November 2023

ObjectiveWe aimed to explore the association between serum complements and kidney function of diabetic kidney disease (DKD) in Chinese patients.MethodsThis is a retrospective study involving 2,441 participants. DKD was diagnosed according to the Kidney Disease: Improving Global Outcomes (KDIGO) categories. Participants were classified as stages G1-G5 by KDIGO glomerular filtration rate (GFR) categories. Effect sizes are expressed as odds ratio (OR) with 95% confidence interval (CI).ResultsAfter balancing age, gender, systolic blood pressure (SBP), hemoglobin A1c (HbA1C), serum triglyceride (TG), and urinary albumin-to-creatinine ratio (UACR) between the G2-G5 and control groups, per 0.1 g/L increment in serum complement C3 was significantly associated with a 27.8% reduced risk of DKD at G5 stage (OR, 95% CI, P: 0.722, 0.616-0.847, &lt;0.001) relative to the G1 stage. Conversely, per 0.1 g/L increment in serum complement C4 was associated with an 83.0-177.6% increased risk of G2-G5 stage (P&lt;0.001). Serum complement C1q was not statistically significant compared to controls at all stages prior to or after propensity score matching.ConclusionsOur results indicate that high concentrations of serum C4 were associated with the significantly elevated risk of kidney function deterioration across all stages, and reduced serum C3 levels with an increased risk of DKD stage G5.
Interleukin-17 and inflammatory bowel disease: a 2-sample Mendelian randomization study
Authors: Cai Yangke , Jia Xuan , Xu Liyi , Chen Hanwen , Xie Siyuan , Cai Jianting 
Published: November 2023

IntroductionObservational studies have discovered a contradictory phenomenon between interleukin-17 (IL-17) and inflammatory bowel disease (IBD). The study aimed to confirm the causal association between each subtype of IL-17 and IBD.MethodsWe performed a 2-sample univariable and multivariable mendelian randomization (MR) to determine which subtype of IL-17 is causally related to IBD and its subtypes, and used a series of sensitivity analysis to examine the reliability of the main MR assumptions.ResultsWe found that IL-17B, IL-17E and IL-17RB were significantly associated with an increased risk of UC (IL-17B: OR: 1.26, 95% CI, 1.09-1.46, P &lt; 0.01; IL-17E: OR: 1.17, 95% CI, 1.05-1.30, P &lt; 0.01; IL-17RB: OR: 1.30, 95% CI, 1.20-1.40, P &lt; 0.0001) while IL-17C and IL-17RC showed causal effects on the increased risk of CD (IL-17C: OR: 1.23, 95% CI, 1.21-1.26, P &lt; 0.0001; IL-17RC: OR: 2.01, 95% CI, 1.07-3.75, P=0.03). The results of multivariable MR (MVMR) showed that the causal effects of IL-17B and IL-17E on UC were unilaterally dependent on IL-17RB, while the effects of IL-17C and IL-17RC on CD were interdependent.DiscussionOur study provided new genetic evidence for the causal relationships between each subtype of IL-17 and IBD, promoting future mechanistic research in IBD.
High-dimensional mass cytometry reveals systemic and local immune signatures in necrotizing enterocolitis
Authors: Liu Yufeng , Zhou Jialiang , Chen Baozhu , Liu Xiao , Cai Yao , Liu Wei , Hao Hu , Li Sitao 
Published: November 2023

ObjectivePatients with necrotizing enterocolitis display severe gastrointestinal complications of prematurity, but the mechanism driving this clinical profile remains unknown. We used mass cytometry time-of-flight to characterize and compare immune cell populations in the blood and intestine tissue from patients with and without (controls) necrotizing enterocolitis at single-cell resolution.MethodsWe completed a deep mapping of the immune system of the peripheral blood mononuclear cells and intestinal mucosa tissue using mass cytometry to evaluate immune cell types, which revealed global immune dysregulation characteristics underlying necrotizing enterocolitis.ResultsCompared with controls, natural killer cells display signs of heightened activation and increased cytotoxic potential in the peripheral blood and mucosa of patients with necrotizing enterocolitis. Furthermore, CD4+ T effector memory cells, non-classical monocytes, active dendritic cells, and neutrophils were specifically enriched in the mucosa, suggesting trafficking from the periphery to areas of inflammation. Moreover, we mapped the systemic and local distinct immune signatures suggesting patterns of cell localization in necrotizing enterocolitis.ConclusionWe used mass cytometry time-of-flight technology to identify immune cell populations specific to the peripheral blood and intestinal mucosa tissue from patients with necrotizing enterocolitis and controls. This information might be used to develop precise diagnosis and therapies that target specific cell populations in patients with necrotizing enterocolitis.
Application of the #Enzian classification for endometriosis on MRI: prospective evaluation of inter- and intraobserver agreement
Authors: Harth Sebastian , Kaya Hasan Emin , Zeppernick Felix , Meinhold-Heerlein Ivo , Keckstein Jörg , Yildiz Selcuk Murat , Nurkan Emina , Krombach Gabriele Anja , Roller Fritz Christian 
Published: November 2023

ObjectivesThe purpose of this investigation was to evaluate the inter- and intraobserver variability of the updated #Enzian classification of endometriosis on MRI and to evaluate the influence of reader experience on interobserver concordance.MethodsThis was a prospective single-center study. All patients were included who received an MRI of the pelvis for evaluation of endometriosis between March and July 2023 and who have provided written informed consent. Images were reviewed independently for endometriosis by three radiologists, utilizing the MRI-applicable categories of the #Enzian classification. Two radiologists had experience in pelvic MRI and endometriosis imaging. One radiologist had no specific experience in pelvic MRI and received a one-hour briefing beforehand.ResultsFifty consecutive patients (mean age, 34.9 years ±8.6 [standard deviation]) were prospectively evaluated. Interobserver agreement was excellent for diagnosis of deep infiltrating endometriosis (Fleiss’ kappa: 0.89; 95% CI 0.73–1.00; p &lt; 0.001) and endometriomas (Fleiss’ kappa: 0.93; 95% CI 0.77–1.00; p &lt; 0.001). For the experienced readers, interobserver agreement in the assessment of compartments A, B and C was excellent (κw ranging from 0.84; 95% CI 0.71–0.97; p &lt; 0.001 to 0.89; 95% CI 0.82–0.97; p &lt; 0.001). For the pairings of the experienced readers to the reader without specific experience in pelvic MRI, agreement was substantial to excellent (κw ranging from 0.64; 95% CI 0.44–0.85; p &lt; 0.001 to 0.91; 95% CI 0.84–0.98; p &lt; 0.001). Intraobserver variability was excellent for compartments A, B and C (κw ranging from 0.85; 95% CI 0.73–0.96; p &lt; 0.001 to 0.95; 95% CI 0.89–1.00; p &lt; 0.001).ConclusionWith sufficient experience, the #Enzian classification enables the achievement of excellent inter- and intraobserver agreement in MRI-based diagnosis of deep infiltrating endometriosis and endometriomas.
The efficacy and safety of general anesthesia vs. conscious sedation for endovascular treatment in patients with acute ischemic stroke: a systematic review and meta-analysis
Authors: Zhao Jiashuo , Tan Xin , Wu Xin , Li Jiaxuan , Wang Shixin , Qu Ruisi , Chu Tianchen , Chen Zhouqing , Liu Jiangang , Wang Zhong 
Published: November 2023

BackgroundEndovascular thrombectomy (EVT) is an important treatment for patients with acute ischemic stroke (AIS). A number of studies have suggested that anesthesia type (conscious sedation vs. general anesthesia) during intra-arterial treatment for acute ischemic stroke has implications for patient outcomes.MethodsPubMed, EMBASE, Cochrane Library and clinicaltrials.gov were searched for randomized controlled trials (RCTs) that were performed to evaluate general anesthesia (GA) and conscious sedation (CS) up to May 30, 2023. Review Manager 5.3 software was used to assess the data. The risk ratio (RR) and mean difference (MD) were analyzed and calculated with a fixed effect model.ResultsWe pooled 930 patients from seven RCTs. We conducted a meta-analysis comparing the outcomes of GA and CS in the included trials. The rate of functional independence in the GA group was higher than that in the CS group (RR: 1.17, 95% CI: 1.00–1.35; P = 0.04; I2 = 16%). The GA group had a higher successful recanalization rate than the CS group (RR: 1.15, 95% CI: 1.08–1.22; P &lt; 0.0001; I2 = 26%). The GA group had a higher pneumonia rate than the CS group (RR: 1.69, 95% CI: 1.22–2.34; P = 0.002; I2 = 26%). In addition, there was no significant difference between GA and CS with respect to the National Institutes of Health Stroke Scale (NIHSS) score at 24 h (P = 0.62), Modified Rankin Scale (mRS) score at 90 days (P = 0.25), intracerebral hemorrhage (P = 0.54), and mortality at 3 months (P = 0.61).ConclusionGA demonstrated superiority over CS in achieving successful recanalization and functional independence at 3 months when performing EVT in AIS patients. However, it was also associated with a higher risk of pneumonia. Further studies, particularly those with long-term follow-ups, are necessary to identify precise strategies for selecting the appropriate anesthetic modality in EVT patients.Systematic review registrationINPLASY202370116.
Case report: Coexistence of triple-seronegative myasthenia gravis and pathology-proven cryptogenic organizing pneumonia
Authors: Huang Shi-Qi , Wang Bin , Gao Lin , Wang Meng , Zhao Hong-Dong , Shi Jian-Quan 
Published: November 2023

ObjectiveEmerging evidence shows that patients with myasthenia gravis (MG) were at a higher risk for the co-occurrence of other autoimmune diseases, which reflects phenotypic heterogeneity in MG. The coexistence of MG and cryptogenic organizing pneumonia (COP) has rarely been reported. The present case is to report the coexistence of triple-seronegative MG and pathology-proven COP in a patient.MethodsThe clinical data of the patient were derived from medical records of Nanjing First Hospital, Nanjing Medical University, China. Written informed consent was obtained from the patient.ResultsWe presented a 56-year-old man with acute respiratory syndrome, who was diagnosed with COP based on the intra-alveolar fibroinflammatory buds (Masson's bodies) in the pathology of bronchoscopy biopsy. Oral prednisone induced dramatic symptomatic improvement and complete resolution of previous lung lesions. After a stable course of no respiratory symptom for 2 months, he was referred to the neurology department with complaints of fluctuating generalized muscle weakness. He was diagnosed with triple-seronegative MG based on fluctuating weakness, neostigmine test-positivity and RNS-positivity. After three-month treatment with pyridostigmine in combination with tacrolimus, the symptoms gradually improved and he achieved minimal symptom expression.ConclusionsThis case highlights the rare coexistence of triple-seronegative MG and pathology-proven COP. However, a causal association between COP and MG cannot be explicitly ascertained. In future, more data are needed to clarify the relationship, taking into account the limited number of cases reported with this coexistence of the diseases.
Exploring the relationship between IGHMBP2 gene mutations and spinal muscular atrophy with respiratory distress type 1 and Charcot-Marie-Tooth disease type 2S: a systematic review
Authors: Tian Yuan , Xing Jinfang , Shi Ying , Yuan Enwu 
Published: November 2023

BackgroundIGHMBP2 is a crucial gene for the development and maintenance of the nervous system, especially in the survival of motor neurons. Mutations in this gene have been associated with spinal muscular atrophy with respiratory distress type 1 (SMARD1) and Charcot-Marie-Tooth disease type 2S (CMT2S).MethodsWe conducted a systematic literature search using the PubMed database to identify studies published up to April 1st, 2023, that investigated the association between IGHMBP2 mutations and SMARD1 or CMT2S. We compared the non-truncating mutations and truncating mutations of the IGHMBP2 gene and selected high-frequency mutations of the IGHMBP2 gene.ResultsWe identified 52 articles that investigated the association between IGHMBP2 mutations and SMARD1/CMT2S. We found 6 hotspot mutations of the IGHMBP2 gene. The truncating mutations in trans were all associated with SMARD1.ConclusionThis study provides evidence that the complete LOF mechanism of the IGHMBP2 gene defect may be an important cause of SMARD1.
Testing central auditory processing abilities in older adults with and without dementia using the consonant-vowel dichotic listening task
Authors: Littlejohn Jenna , Blackburn Daniel J. , Venneri Annalena 
Published: November 2023

BackgroundHearing loss and dementia are linked, although the roles of peripheral and central auditory dysfunction are not well defined. Many behavioral measures of hearing are confounded by the overlapping cognitive functions required to perform the tests.ObjectiveTo collect pilot data to identify how central auditory function, measured using a dichotic listening test that indexes both auditory and cognitive components under different attentional conditions, differs among people with mild cognitive impairment (MCI), dementia and controls, and how performance relates to neuropsychological results.MethodFifty-eight participants (17 MCI, 11 dementia and 30 controls) undertook hearing screening, the Bergen consonant-vowel dichotic listening paradigm, and a short battery of neuropsychological tests chosen to index attention and executive control. Dichotic listening was assessed under three attentional conditions (non-forced, forced right ear and forced left) amongst older adults with normal cognitive function, MCI and dementia.ResultsWe report two main findings: (a) The expected right ear advantage under non-forced conditions, was seen in controls and patients with dementia but not in people with MCI, who showed equal numbers of correct responses from both ears (i.e., a lack of asymmetry); (b) Performance under forced attentional conditions was significantly associated with disease progression (i.e., control &gt; MCI &gt; dementia) and performance on the cognitive tasks.ConclusionThe reduction in asymmetry on dichotic listening tasks may be a marker of MCI and reflect underlying compensatory mechanisms. Use of this test could aid stratification of patients with memory disorders. Whether abnormalities could predict dementia onset needs longitudinal investigation in a larger sample.