bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taxes, Trading, and the Value of Real Estate
Authors: Scholes Myron S. , Terry Eric , Wolfson Mark A. 
Published: January 2025

Models of optimal trading strategy for real estate typically compare the benefits of stepping up the depreciable basis of property against the cost of depreciation recapture and capital gains taxes. These models routinely predict holding periods that are much longer than those that actually occur. Although this predictive failure can be explained in part by the omission from these models of nontax motivations for property turnover, we argue that an important taxfeature has also been ignored: namely, the special treatment accorded installment sales under Section 453 of the Internal Revenue Code. We demonstrate that when installment sales of property are used, predicted property values and turnover rates increase significantly prior to the 1986 Tax Reform Act. In contrast, installment sales are shown to have only minor impact after the 1986 Act. To derive our results, we rely on a simple dynamic programming model that determines both optimal trading strategies and market values. We also cite empirical evidence that supports our model. We further investigate the sensitivity of property market values and turnover rates to the magnitude of nontax transaction costs that are incurred when investors trade real estate. Here we show that when installment sales are ignored, transaction costs have very little effect on property values and turnover rates because recapture taxes and capital gains taxes are, by themselves, sufficient to deter frequent sales. But when installment sales are introduced, market values and turnover rates become quite sensitive to the size of the nontax transaction costs.
Antifungal-drug interactions in oncology: A cross-sectional study highlighting the role of pharmacists
Authors: Akbar Zunaira , Aamir Muhammad , Saleem Zikria , Khan Muhammad Rehan 
Published: January 2025

Study objective Complex pharmacotherapy in cancer patients increases the likelihood of drug-drug interactions (DDIs). Pharmacists play a critical role in the identification and management of DDIs. The aim of present study was to evaluate the role of pharmacist in identifying antifungal drug interactions in cancer patients and providing relevant recommendations. Methodology A retrospective, cross-sectional study was conducted to identify antifungal drug interactions over the period of 5 years (2019–2023) among cancer patients. Electronic medical record of 384 hospitalized patients receiving systemic antifungal therapy were reviewed. Severity of interactions and risk classification were made using UptoDate® LexidrugTM software. Pharmacists’ recommendations regarding DDIs were also documented. Descriptive statistics and logistic regression were applied to interpret results. Results Antifungals were more frequently prescribed to adult patients (53.9%). Female cancer patients were significantly more likely to encounter DDIs than males ( p < 0.003). Type of cancer and fungal infections were significantly associated with incidence of DDIs ( p < 0.01; p = 0.000). Pharmacist identified DDIs in 53.9% antifungal prescriptions with 22.2% classified as major interactions. A substantial proportion of these interactions involved voriconazole (40.1%). Majority of pharmacist's recommendations included dose optimization of voriconazole (10.4%), close monitoring of RFTs (8.9%) and withholding amphotericin (5.2%) during chemotherapy. All of the recommendations made by pharmacists were accepted by physicians (100%). Conclusion The findings indicate that pharmacists identified DDIs in 53.9% of prescriptions and all of their recommendations were accepted by physicians. This highlights the critical role of pharmacists in detecting potential interactions, ensuring medication safety, and minimizing adverse effects associated with complex pharmacotherapy.
Yttrium-90 Radioembolization for Intrahepatic Cholangiocarcinoma: Non-University Tertiary Care Center Experience
Authors: Darian Sahar , Malo Juan S. , Lim Joseph S. , Buell Joseph F. , Osman Houssam , Van Meter Travis , Jeyarajah D. Rohan 
Published: January 2025

Background Intrahepatic cholangiocarcinoma (ICC) presents a significant clinical challenge due to its high fatality rate and limited surgical candidacy. With only 30-40% of patients eligible for surgery upon diagnosis, alternative therapies are imperative. This study assesses the efficacy of Yttrium-90 (Y-90) radioembolization for unresectable ICC patients in a non-university tertiary care center (NUTCC). Methods A retrospective analysis of 15 unresectable ICC patients treated with Y-90 radioembolization was conducted. Tumor response, survival, and adverse events were evaluated using RECIST criteria. Results 60% of patients exhibited partial response, and 20% showed stable disease, with notable tumor size reduction and a median survival of 14 months. Minimal adverse effects were observed, indicating Y-90’s favorable safety profile. Conclusion Y-90 radioembolization shows potential in reducing tumor burden and enhancing survival rates with minimal adverse effects for unresectable ICC. Larger prospective studies are needed to confirm its efficacy and define its role in ICC treatment protocols.
Management of Psychosis and Schizophrenia by Primary Care GPs: A Cross-Sectional Study in Spain
Authors: Sepúlveda-Muñoz Jesús , Quemada González Casta , Hurtado Lara María M. , Gutiérrez García Ángel Manuel , Martí-García Celia , García-Herrera Pérez-Bryan José María , Morales-Asencio José Miguel 
Published: January 2025

Aim: To investigate the detection and initial management of first psychotic episodes, as well as established schizophrenia, within the primary care of the Andalusian Health System. Background: Delay in detecting and treating psychosis is associated with slower recovery, higher relapse risk, and poorer long-term outcomes. Often, psychotic episodes go unnoticed for years before a diagnosis is established. Primary care physicians are crucial for early recognition of psychosis and schizophrenia, especially in Spain, where primary care is the main entry point to healthcare services. Methods: Cross-sectional exploratory study. All active primary care physicians in the Malaga Guadalhorce Health District were invited to participate. Due to the COVID-19 pandemic, the survey was conducted online. The survey, adapted and validated for the local context, included 22 items and 5 sociodemographic questions covering early detection, treatment options, physical health monitoring, and management challenges. Descriptive and bivariate analyses summarized the data and explored correlations between key variables. Findings: The study included 142 primary care physicians (response rate 35.5%), with 28.9% men and 71.1% women, primarily from urban areas (83.1%). Most had completed residency training (86.6%), with 79.6% receiving psychiatric training. However, only 5.6% had participated in training sessions in the last 5 years, with all such sessions lasting less than 30 h. Physicians typically managed 0-10 patients with diagnosed schizophrenia and saw these patients 2 to 3 times annually. They often felt capable of managing these patients, especially with mental health consultancy support. Physical health monitoring was common, though some relied on mental health services to do this. Collaboration with mental health services was moderate, with high utility perceived for having a list of patients with severe mental disorders in their care panel. Conclusions: Family physicians are generally confident in managing psychosis and schizophrenia but lack recent specialized training. Mental health consultancy services are valued, but collaboration with these services needs improvement. Clear guidelines and enhanced training are essential to ensure comprehensive care, addressing both mental and physical health needs of these patients.
Study of Risk Factors in Global Stock Markets During the COVID-19 Pandemic Under Different Market Conditions
Authors: Jareño Francisco , Martínez-Serna María-Isabel , Sánchez Pablo 
Published: January 2025

In this paper, we examine the stock markets’ response to fluctuations in international risk factors under different market states during the COVID-19 pandemic. Using data from seven countries heavily affected by the sanitary crisis, over the period between January 2020 and December 2021, we estimate an extended risk factor model through the quantile regression approach, with the purpose of identifying distinct sensitivities to risk sources depending on the bullish or bearish state of the market. Our results suggest higher explanatory ability at extreme quantiles, thereby revealing significant disparities in sensitivities, that are found to be dependent on the market conditions, on the country and on the particular risk factor. JEL classification: C22, C51, F21, G12, G32, H12
Sex- and Age-Specific Analysis of Mountain Biking Injuries: A 10-Year Review of National Injury Data
Authors: Koehne Niklas H. , Locke Auston R. , Yendluri Avanish , Parsons Bradford O. , Waterman Brian R. , Alaia Michael J. , Frank Rachel M. , Parisien Robert L. 
Published: January 2025

Background: Mountain biking (MTB) is a quickly growing sport, with many athletes sustaining high-impact injuries. Current literature has not analyzed the most recent MTB-related national emergency department (ED) injury data. Hypothesis: It was hypothesized that (1) the total number of injuries presenting to US EDs would significantly increase over the study period, (2) male patients would experience higher rates of shoulder injuries and airborne injury mechanisms than female patients, and (3) youths would present more frequently with injuries of the head and face than adults. Study Design: Descriptive epidemiology study. Methods: All data were extracted from the National Electronic Injury Surveillance System (NEISS), a public database representing approximately 100 US EDs. The NEISS was queried for MTB-related injuries between January 1, 2013, and December 31, 2022. Results: A total of 2543 MTB-related cases presented to US EDs between 2013 and 2022, which extrapolated to a national estimate (NE) of 109,558 injuries using NEISS sample weights. MTB-related injuries increased significantly between 2013 and 2022 ( P = .009), including a 64% increase between 2019 and 2020. The most common injury mechanism was falling off the bike (62.6%; NE = 68,536), and the upper extremity was the most frequently injured body region (22.4%; NE = 24,511). Male patients presented with significantly more shoulder (21.1% vs 7.4%, respectively; P < .001) and trunk (21.4% vs 19.8%, respectively; P < .001) injuries than female patients as well as more airborne injury mechanisms (15.7% vs 10.8%, respectively; P < .001). Female patients sustained significantly more concussions (7.2% vs 3.5%, respectively; P < .001) than male patients. Children presented with higher rates of head/face injuries (34.1%), concussions (6.0%), and airborne mechanisms of injury (19.4%) than any other age group. Conclusion: MTB injuries increased significantly between 2013 and 2022 likely because of the popularity of outdoor sports during COVID-19. The upper extremity was the most frequently injured body region, and falling off the bike was the most common mechanism. Leading injuries and mechanisms varied significantly by sex and age. This study recommends additional MTB safety measures such as shoulder support for male riders, better coaching on front brake control for youth riders, and an increased emphasis on concussion protocols for female riders.
Enhancing mechanical and erosive properties of hybrid polymer composites using synergistic fiber-filler interactions
Authors: Jani SP , Arul Sujin Jose , Adam Khan M , Ramulu P Janaki , Esleman Esmael Adem 
Published: January 2025

This study explores the mechanical, water absorption, and erosive wear properties of hybrid polymer composites reinforced with treated hemp, carbon, and basalt fibers. The composites were fabricated using the hand lay-up method, with epoxy resin as the matrix and fillers (CaCO3 and coconut fiber) incorporated to enhance performance. Treated hemp fibers underwent 5% NaOH treatment to improve fiber-matrix adhesion, and ASTM standards were followed for tensile, flexural, and impact tests. Water absorption was monitored over 10 days, and solid particle erosion was assessed under varying impingement angles. Results showed that Sample B2 (20% treated hemp, 6% basalt) exhibited superior mechanical properties, including flexural strength (15% higher than comparable samples) and impact resistance (10% higher). Treated fibers and fillers minimized water absorption, while erosion resistance was maximized in carbon-basalt composites. SEM analysis confirmed uniform fiber dispersion and strong interfacial bonding in optimal samples, leading to improved load transfer and mechanical stability. This study demonstrates the potential of hybrid composites as high-performance materials for automotive, aerospace, and construction applications, emphasizing the critical role of balanced fiber composition and chemical treatments in optimizing material properties.
Advancing Health Equity in Integrative Health: The Role of Collaborative Educational Partnerships in Addressing Structural Racism
Authors: Zhang Xiaoqing , Mullur Rashmi S. , Riopelle Cameron , Mehta Darshan H. , Vega Nanette , Parker Tabatha , Soriano Scarlet , Price Jessica R. , Miller Yvette Marie , Davis I. Jean , Chandran Latha 
Published: January 2025

Background Integrative Health (IH) professional organizations are responsible for advancing health equity and addressing structural racism. Objective The Academy of Integrative Health and Medicine (AIHM) partnered with the University of Miami Miller School of Medicine to co-create a longitudinal curriculum for its board and staff to address structural racism and health equity in IH. Methods We administered a 2-phase curriculum addressing health equity in IH. We evaluated the curriculum with pre & post-surveys of knowledge, attitudes, skills, and behaviors and conducted a qualitative analysis of open-ended questions and personal reflections. Results Thirty one respondents took the pre-training survey. The mean knowledge scores for each seminar improved. Qualitative analysis revealed that participants grappled with the pervasiveness of racism and bias engrained within health care. Conclusion This curriculum serves as a valuable model for IH professional organizations aiming to address their role in disrupting the effects of racism on health outcomes.
Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment
Authors: Benjamin Amy Sarah , Nayak Sunita 
Published: January 2025

Abstract
Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of targeted therapies in cancer care. A significant innovation in this area is the use of nanotechnology, specifically nanoparticles, to tackle various challenges in cancer treatment. Iron oxide nanoparticles stand out in both therapeutic and diagnostic applications, offering a versatile platform for targeted drug delivery, hyperthermia, magneto-thermal therapy, and combinational therapy using modulation of ferroptosis pathways. These nanoparticles are easy to synthesize, non-toxic, biocompatible, and display enhanced circulation time within the system. They can also be easily conjugated to anti-cancer drugs, targeting agents, or genetic vectors that respond to specific stimuli or pH changes. The surface functionalization of these nanoparticles using bioactive molecules unveils a promising and effective nanoparticle system for assisting osteosarcoma therapy. This review will summarize the current conventional therapies for osteosarcoma and their disadvantages, the synthesis and modification of iron oxide nanoparticles documented in the literature, cellular targeting and uptake mechanism, with focus on their functionalization using natural biomaterials and application strategies towards management of osteosarcoma. The review also compiles the translational challenges and future prospects that must be addressed for clinical advancements of iron oxide based osteosarcoma treatment in the future.

Graphical abstract
Effect of gut microbiota changes on cytokines IL-10 and IL-17 levels in liver transplantation patients
Authors: Abdel-Raoof Fouda Mohamed , Abdel-Wahhab Mohamed , Abdelkader Ahmed Esmail , Ibrahim Mohsen El-Sayd , Elsheikh Taher Abozeid , Aldeweik Hisham Mohammad , Elfeky Nora 
Published: January 2025

Abstract

Background
Liver transplantation (LT) is a critical intervention for individuals with end-stage liver disease; yet, post-transplant problems, especially infections, graft rejection, and chronic liver disease, are often linked to systemic inflammation. Cytokines, small signaling molecules, significantly influence immune responses during and post-liver transplantation. Nonetheless, the intricate relationships among cytokines, immune responses, and the gut microbiota, especially gut dysbiosis, are still inadequately comprehended. Thus, this study aims to identify the gut microbiota (GM) and determine their relationship to cytokines (IL-17 and IL-10) in LT patients, due to their importance in enhancing the recovery rate.

Result
The research included 31 liver transplant (LT) patients from the Gastroenterology Surgical Center at Mansoura University, resulting in the collection of 174 stool and blood samples from all participants. Fourteen bacterial species have been identified in samples collected at three intervals: one week before, one week post, and two weeks post LT. A change in gut microbiota composition was noted, characterized by a rise in potentially pathogenic bacteria such as Enterococci and Enterobacteriaceae (including Escherichia coli and Klebsiella) and a reduction in beneficial bacteria such as Bacteroidetes and Firmicutes. The examination of patient demographic and clinical data revealed no significant correlations between sex, age, or diagnostic categories and gut microbiota composition. The findings of the Multivariate Analysis of Variance (MANOVA) indicated a substantial effect of gut microbiota composition on cytokine levels (IL-10 and IL-17), with all tests producing p-values of 0.001. The assessment of cytokine levels indicated fluctuating variations at several time points following surgery. IL-10 levels in the GM groups exhibited a statistically significant elevation during the second week post-surgery (p = 0.036), suggesting a potential recovery-related anti-inflammatory response. In contrast, IL-17 levels rose in the NI group over time, indicating a transition to a pro-inflammatory condition.

Conclusion
This study emphasizes the pivotal role of the gut microbiota in regulating immune responses following transplantation.
Bullying victimization and suicidal ideation among Chinese adolescents: a moderated mediation model of depressive symptoms and perceived family economic strain
Authors: Jiang Xiaoyu , Wei Qiaoyue , Yin Wenwen , Pan Shuibo , Dai Chenyangzi , Zhou Linhua , Wang Chunyan , Lin Xiujin , Wu Junduan 
Published: January 2025

Abstract

Background
There is substantial evidence linking bullying victimization to suicidal ideation, but the mechanism behind this link is not well understood. This study investigates whether depressive symptoms mediate the relationship between bullying victimization and suicidal ideation, and whether perceived family economic strain moderates this mediation.

Methods
Data were collected from 7,702 adolescents (mean age = 14.74 ± 1.69 years, 52% girls) using a self-report questionnaire that assessed bullying victimization, depressive symptoms, suicidal ideation and perceived family economic strain. Mediation and moderated mediation analyses were conducted using the PROCESS macro in SPSS.

Results
Suicidal ideation was significantly associated with both bullying victimization and depressive symptoms, as determined by linear regression analysis (both p < 0.001). The relationship between bullying victimization and suicidal ideation was partially mediated by depressive symptoms, accounting for 66.74% of the effect. Additionally, perceived family economic strain could moderate the link between bullying victimization and depressive symptoms (β=-0.017, p < 0.001), indicating that increased perceived family economic strain attenuates the impact of bullying victimization on depressive symptoms.

Conclusion
Our research affirms bullying victimization substantial influence on adolescent suicidal ideation, with depressive symptoms mediating this link. The study also reveals that perceived family economic strain moderates this relationship, indicating the necessity for interventions that address both psychological and economic factors to holistically support the mental health of bullied adolescents.
Communicative health literacy with physicians in healthcare services– results of a Hungarian nationwide survey
Authors: Israel Frederico Epalanga Albano , Vincze Ferenc , Ádány Róza , Bíró Éva 
Published: January 2025

Abstract

Background
In an efficient and effective healthcare delivery, good communication plays an essential role. The communicative health literacy (COMM-HL) of the patients is an important attribute, but the number of validated COMM-HL assessment tools is low, and they do not cover all aspects of COMM-HL. That’s why a new scale has been developed within an international collaboration. Our aims are to check the measurement properties of the Hungarian version of this COMM-HL questionnaire, to describe the COMM-HL of the Hungarian adult population and to investigate its determinants.

Methods
A total of 1205 adults completed the telephone interview in 2020 as part of the European Health Literacy Population Survey 2019–2021. The questionnaire included items on sociodemographic data, self-perceived health, social support and COMM-HL. The questionnaire’s measurement properties were assessed using Cronbach’s alpha, Spearman-Brown, and item-total correlation coefficients, while the construct validity was investigated with principal component (PCA) and confirmatory factor analysis. The determinants of the COMM-HL were investigated by linear regression.

Results
Both the value of Cronbach’s alpha and the Spearman-Brown correlation were 0.87. The items belonged to one factor and 62.2% of the total variation was explained by this factor based on the PCA. The fit indices indicated that the one-factor structure of the six-item questionnaire exhibited a good fit for the data. The mean score on the COMM-HL scale was 86.8. The easiest task was explaining health concerns while getting enough time in the consultation was rated as the most difficult one. COMM-HL was lower among females, while it was higher among people aged 66–75 years (compared with 18–25 years), those with greater social support and those without financial deprivation.

Conclusions
The questionnaire can be characterized with good internal consistency and the structure of the COMM-HL questionnaire was best explained as a one factor model. In consultations with patients, the effectiveness of communication should be improved, so that patients do not feel that there is not enough time for consultation. At-risk groups with low COMM-HL need special attention during the interactions and the role of social support has to be clarified, too.