bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma adiponectin and biomarker‐confirmed Alzheimer's disease in a tertiary memory clinic
Authors: Sindzingre Louise , Bouaziz‐Amar Elodie , Mouton‐Liger François , Cognat Emmanuel , Dumurgier Julien , Götze Karl , Martinet Matthieu , Vrillon Agathe , Paquet Claire , Lilamand Matthieu 
Published: January 2025

AbstractAlzheimer's disease (AD) is associated with early metabolic dysfunction and adiponectin, which may play a pathophysiological role. Adiponectin is implicated in the regulation of energy homeostasis, carbohydrate, and lipid metabolism, as well as in inflammation modulation. The aim of this study was to study whether plasma adiponectin levels were different between patients with AD confirmed by biomarkers and neurological control subjects. We performed a monocentric, retrospective, cross‐sectional, observational study in AD patients and neurological controls recruited from daily clinical practice in a tertiary memory clinic. Plasma adiponectin levels were measured using a chemiluminescent enzyme immunoassay. We analyzed the relationship between adiponectin and AD using linear regression models including age, gender, and BMI. We also described the distribution of adiponectin concentrations, across age, and gender categories. Two hundred and six patients (142 AD patients and 64 neurological controls) were included, with mean age = 68.8 ± 10.0 years, and 56% were women. Higher adiponectin concentrations were observed in females and in older adults. Plasma adiponectin levels were significantly higher in AD patients (mean = 6.45 ± 3.42 μg/mL) than neurological controls (4.85 ± 3.54 μg/mL) (p < .001). This association was mediated by age, gender, and BMI, which were significantly and independently associated with plasma adiponectin levels (p < .01 for each), while adiponectin was no longer associated with AD in multivariate models. Patients with AD showed higher adiponectin levels, but this association was driven by older age, female gender, and lower BMI in the AD group. Further studies are needed to better characterize the hormonal signature of AD.
The Allocation of Socially Responsible Capital
Authors: GREEN DANIEL , ROTH BENJAMIN N. 
Published: January 2025

ABSTRACTPortfolio allocation decisions increasingly incorporate social values. We develop a tractable framework to study how competition between investors to own socially valuable assets affects social welfare. Relative to the most common social‐investing strategies, we identify alternative strategies that result in higher impact and higher financial returns. We identify strategies for investors to have impact when impact is difficult to measure. From the firm's perspective, increasing profitability can have greater impact than directly increasing social value. We present new empirical evidence on the social preferences of investors that demonstrates the practical relevance of our theory.
Tissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures
Authors: Tavelli Lorenzo , Nguyen Tu , Rodriguez Maria Vera , Mancini Leonardo , Giannobile William V. , Barootchi Shayan 
Published: January 2025

ABSTRACTAimTo assess tissue perfusion changes and wound healing biomarker levels after root coverage procedures with coronally advanced flap in combination with the cross‐linked xenogeneic collagen matrix (CCMX), loaded either with a placebo or recombinant human platelet‐derived growth factor‐BB (rhPDGF).MethodsThis study was designed as a secondary analysis from a previously published clinical trial, and it assessed the tissue perfusion changes over 6 months around multiple gingival recession defects, treated with either with CCMX alone (control) or with CCMX + rhPDGF (test). High frequency Doppler ultrasonography (HFUS) scans were obtained at sites of interest at baseline, 2 weeks, 3 months, and 6 months after surgery. Dynamic tissue perfusion measurements (DTPMs) were performed at the midfacial, interproximal, and transverse aspects of the teeth by an operator, blinded to treatment allocation, using a software package. The expression of different wound healing biomarkers from the gingival crevicular fluid was also assessed.ResultsThe regression analyses showed similar tissue perfusion changes between the two groups throughout the majority of the 6 months. DTPMs at 2 weeks showed the test group to have significantly higher perfusion relief intensity (pRI, p < 0.001), mean perfused area (pA, p < 0.001), mean blood flow intensity (FImean, p = 0.021), and total blood flow intensity (FItot, p = 0.021) at the graft region of interest (ROI) compared to control sites. The test sites also exhibited significantly greater pA (p = 0.033) and blood flow intensity “blue” (FIblue, meaning flow away from the transducer, p = 0.035) at the level of the flap compared to the control sites. At 2 weeks, FIblue of the graft was directly correlated with the final mean root coverage (p = 0.008) and complete root coverage (p = 0.003). FImean and FItot of the graft exhibited a direct correlation with volume gain at 6 months (p = 0.031 for both parameters). The final GT gain was correlated to the early DTPMs (pA and FIblue) of the graft and the flap. The two groups exhibited different expressions of IL‐1β, PDFG‐BB, and VEGF over 3 months, with the 1‐week levels of PDGF‐BB that were associated with time to recovery.ConclusionsHFUS allowed exquisite assessment of tissue perfusion occurring at the entire surgical reconstructive regions and also within the flap and the graft. Sites treated with CCMX + rhPDGF exhibited higher DTPMs, primarily within the graft and flap ROIs at the 2‐week timepoint compared to sites augmented with CCMX + saline. Early DTPMs at the graft and flap ROIs showed associations with PROMs and the final clinical outcomes.Trial Registration: ClinicalTrials.gov: NCT04462237
Non‐territorial arrangements in interwar Soviet Ukraine: The development of the judicial network for minority populations
Authors: Palko Olena 
Published: January 2025

AbstractIn the 1920s, in Soviet Union ethnicity became territorially institutionalised, meaning that every Soviet nationality was promised a territory of their own, either in the form of a separate or an autonomous Soviet republic, national region or a separate national town or village council (soviet). Within those national‐territorial units, the Soviet state strove to provide access to state institutions, political representation, police and judicial protection, healthcare, education and cultural opportunities in the minority language. Ukraine's minorities, however, were often linguistically assimilated and territorially dispersed, making the Bolshevik territorial solutions, with some exceptions, ill‐suited to serve the republic's non‐Ukrainian population. Using the development of judicial network for minorities in early Soviet Ukraine as a case study, this article demonstrates how in the Soviet context, non‐territorial arrangements, despite conceptual resentment, were incorporated into everyday practices in parallel with national territorialisation. By doing so, this article aims to examine some overlooked aspects of the early Soviet minorities experiment and determine a correlation between hard‐line Ukrainisation—a policy of linguistic and bureaucratic de‐Russification of the republic and minority policies. Secondly, this study aims to introduce the Soviet case into the context of non‐territorial autonomy developed and implemented throughout postwar Europe.
Stress resilience in plants: the complex interplay between heat stress memory and resetting
Authors: Staacke Tobias , Mueller‐Roeber Bernd , Balazadeh Salma 
Published: January 2025

SummaryHeat stress (HS) poses a major challenge to plants and agriculture, especially during climate change‐induced heatwaves. Plants have evolved mechanisms to combat HS and remember past stress. This memory involves lasting changes in specific stress responses, enabling plants to better anticipate and react to future heat events. HS memory is a multi‐layered cellular phenomenon that, in addition to epigenetic modifications, involves changes in protein quality control, metabolic pathways and broader physiological adjustments. An essential aspect of modulating stress memory is timely resetting, which restores defense responses to baseline levels and optimizes resource allocation for growth. Balancing stress memory with resetting enables plants to withstand stress while maintaining growth and reproductive capacity. In this review, we discuss mechanisms and regulatory layers of HS memory and resetting, highlighting their critical balance for enhancing stress resilience and plant fitness. We primarily focus on the model plant Arabidopsis thaliana due to the limited research on other species and outline key areas for future study.
The splicing auxiliary factor OsU2AF35a enhances thermotolerance via protein separation and promoting proper splicing of OsHSA32 pre‐mRNA in rice
Authors: Liu Jianping , Li Xin , Wang Ke , Wang Tao , Meng Yang , Peng Zhi , Huang Jinli , Huo Jiaohan , Zhu Xiaoqi , Yang Jinyong , Fan Yongxi , Xu Feiyun , Zhang Qian , Wang Zhengrui , Wang Ya , Chen Hao , Xu Weifeng 
Published: January 2025

SummaryHeat stress significantly impacts global rice production, highlighting the critical need to understand the genetic basis of heat resistance in rice. U2AF (U2 snRNP auxiliary factor) is an essential splicing complex with critical roles in recognizing the 3′‐splice site of precursor messenger RNAs (pre‐mRNAs). The U2AF small subunit (U2AF35) can bind to the 3′‐AG intron border and promote U2 snRNP binding to the branch‐point sequences of introns through interaction with the U2AF large subunit (U2AF65). However, the functions of U2AF35 in plants are poorly understood. In this study, we discovered that the OsU2AF35a gene was vigorously induced by heat stress and could positively regulate rice thermotolerance during both the seedling and reproductive growth stages. OsU2AF35a interacts with OsU2AF65a within the nucleus, and both of them can form condensates through liquid–liquid phase separation (LLPS) following heat stress. The intrinsically disordered regions (IDR) are accountable for their LLPS. OsU2AF35a condensation is indispensable for thermotolerance. RNA‐seq analysis disclosed that, subsequent to heat treatment, the expression levels of several genes associated with water deficiency and oxidative stress in osu2af35a‐1 were markedly lower than those in ZH11. In accordance with this, OsU2AF35a is capable of positively regulating the oxidative stress resistance of rice. The pre‐mRNAs of a considerable number of genes in the osu2af35a‐1 mutant exhibited defective splicing, among which was the OsHSA32 gene. Knocking out OsHSA32 significantly reduced the thermotolerance of rice, while overexpressing OsHSA32 could partially rescue the heat sensitivity of osu2af35a‐1. Together, our findings uncovered the essential role of OsU2AF35a in rice heat stress response through protein separation and regulating alternative pre‐mRNA splicing.
Confocal Reflectance Microscopy Findings in Juvenile Xanthogranuloma: Report of 2 Cases
Authors: Midani Lynn , Park Katherine , Stepenaskie Shelly , Smidt Aimee C. , Durkin John R. 
Published: January 2025

ABSTRACTJuvenile xanthogranuloma (JXG) is the most common type of non‐Langerhans cell histiocytosis and is characterized by a benign proliferation of dermal dendrocytes. We report two children diagnosed with JXG with reflectance confocal microscopy (RCM), a noninvasive imaging technology that allows for multi‐layer visualization of the skin. This report demonstrates the emerging role of RCM as a painless diagnostic aid for JXG and other cutaneous diseases in children.
The branched‐chain amino acid‐related isoleucic acid: recent research advances
Authors: Mekonnen D. W. , Ghirardo A. , Zhang W. , Schäffner A. R. 
Published: January 2025

AbstractIsoleucic acid (ILA) was identified in human patients with maple syrup urine disease (MSUD) half a century ago. MSUD patients, who are defective in the catabolism of branched‐chain amino acids (BCAAs), that is, isoleucine, leucine, and valine, have urine with a unique maple syrup odour related to the accumulation of BCAA breakdown products, largely 2‐keto acid derivatives and their reduced 2‐hydroxy acids including ILA. A decade ago, ILA was identified in Arabidopsis thaliana. Subsequent studies in other plant species indicated that ILA is a ubiquitously present compound. Since its identification in plants, several efforts have been made to understand the biological significance and metabolic pathway of ILA. ILA plays a positive role in plant signalling for defence responses against bacterial pathogens by increasing the abundance of salicylic acid aglycone through competitive inhibition of SA deactivation by glucosylation. Here, we review recent progress in the characterization of ILA biosynthesis and function in plants and discuss current knowledge gaps and future directions in ILA research.
Motivations for Abortion or Continuation of an Unwanted Pregnancy: A Scoping Review of the Global Literature
Authors: Beumer Wieke Y. , Reilingh Annemarie Y. A. M. , Dalmijn Eline , Roseboom Tessa J. , van Ditzhuijzen Jenneke 
Published: January 2025

ABSTRACTContextThe aim of this scoping review was to provide an overview of recent studies in peer reviewed journals investigating self‐reported motivations to have an abortion or to continue an unwanted pregnancy in different countries and settings, including both qualitative and quantitative results.MethodsWe searched for English language publications published between 2008 and 2023 indexed in four scientific databases. We included studies if they captured people's own motivations for abortion and/ or for continuing an unwanted pregnancy.ResultsOf the included 19 studies, all focused on abortion, and four also included motivations to carry an initially unwanted pregnancy to term. Motivations for abortion often related to family planning (e.g., complete family, no desire for children, not the right time), the relationship with the person involved in the pregnancy, and life or material circumstances (such as financial resources, housing or future plans), and sometimes with stigma, shame, or expected negative reactions. Motivations to continue an unwanted pregnancy were having a supportive partner and personal beliefs about the pregnancy. Despite different settings, different methods, and methodological limitations, studies showed similar multifactorial and interrelated motivations in decision making around unwanted pregnancies.ConclusionsThis research showed that in different places throughout the world multiple interrelated motivations play a role in a decision to have an abortion or to continue an unwanted pregnancy. The findings mainly provide insight into retrospective explanatory accounts, which may be biased because respondents may feel the need to justify their choice. Future research should discontinue asking people to rationalize unwanted pregnancy decisions.
Liveable, but for Whom? – Perceived Liveability and Citizen Participation in Amsterdam's Red‐Light District
Authors: Basak Oishika , van Liempt Ilse 
Published: January 2025

AbstractPopularly known as Amsterdam's Red‐Light District, De Wallen is one of the Netherlands' most well‐known yet controversial areas. This politicised neighbourhood has witnessed years of gentrification and touristification. Many contemporary debates concerning De Wallen, and the municipality's policy interventions have been around the topic of liveability. This case study examines the neighbourhood's liveability from the eyes of diverse local stakeholders and analyses how their perceptions of liveability get reflected, or not, in the citizen participation mechanisms. De Wallen's stakeholders, apart from the municipality, include residents, business owners, sex workers, socio‐cultural institutions, and employees of various establishments. By interviewing some of these diverse voices, the study highlights the plurality in the liveability perceptions of the local stakeholders. Thus, this research builds onto existing theoretical and empirical work by underscoring the importance of analysing liveability from a contextual lens and evaluating whose liveability perceptions are given primacy while creating policies for an urban area.
A congruence theorem for compact embedded hypersurfaces in S+n+1$\mbox{${\mathbb {S}}$}^{n+1}_+$
Authors: Freitas Allan , Guimarães Felippe 
Published: January 2025

AbstractWe prove a codimension reduction and congruence theorem for compact ‐dimensional submanifolds of that admit a mean convex isometric embedding into using a Reilly‐type formula for space forms.
HUVER: The HyForm Uncrewed Vehicle Engineering Repository
Authors: Karri Abhiram , Stump Gary , McComb Christopher , Song Binyang 
Published: January 2025

Abstract
This paper introduces the HyForm Uncrewed Vehicle Engineering Repository (HUVER), a comprehensive multi-modal dataset of uncrewed aerial vehicle (UAV) designs, complete with performance evaluations, derived from the HyForm UAV design testbed. The dataset includes 6,051 unique UAV configurations, each represented using strings adhering to a designed grammar, images, 3D mesh models, and textual descriptions, alongside performance metrics obtained from physics-based simulations. Designed to support data-driven and AI-driven design processes, one area in which this dataset can facilitate research is the surrogate modeling and generative design of UAVs, providing a resource for developing predictive models and supporting human-AI collaboration in UAV design. The dataset adheres to FAIR principles, ensuring it is retrievable, accessible, interoperable, and reusable, and is made available as an online repository for ease of use by the research community.
Optimal Synthesis of Zero-Stiffness Compliant Mechanisms Based on Potential Energy Principle
Authors: Li Zewei , Jin Mohui , Wang Weisheng , Qu Mingyu , Xu Xing 
Published: January 2025

Abstract
Zero-stiffness compliant mechanisms (ZSCM) can provide constant or zero force over a range of motion without the issues caused by the inherent stiffness of compliant mechanisms (CM). The large-deflection curved beams in ZSCM enhance the mechanism’s performance but pose significant modeling challenges. As an effective method for modeling curved beams, chained pseudo-rigid-body model (CPRBM) can be an intuitive method to implement in ZSCM synthesis. However, its difficulty in solving reaction forces limits its usability in the frequently-used force-based ZSCM synthesis. To address the problem, this article proposes an energy-based method for CPRBM-based ZSCM synthesis, without calculating the reaction force. This method synthesizes the mechanisms with zero-stiffness characteristics by optimizing the energy recorded from the analysis based on the principle of minimum potential energy. Two optimization models based on energy characteristic are developed for constant force CM (CFCM) and statically balanced CM (SBCM), respectively. Synthesis cases and experimental studies are used to verify the proposed method. The results demonstrate that the synthesized ZSCM have good performances and the proposed method can be a user-friendly tool for ZSCM synthesis.
Design of Multi-Agent Systems Based on Bilevel Closed-Loop Planning
Authors: Cao Jinhui , Ming Zhenjun , Allen Janet K. , Mistree Farrokh 
Published: January 2025

Abstract
Advanced multi-agent systems are capable of executing tasks in complex and unknown domains that are unsuitable for humans. However, the design of multi-agent systems faces challenges in balancing global and local decision-making and enabling the system to adaptively generate desired behaviors in a dynamic environment. To address these challenges, in this article, we propose a multi-agent system design framework based on bilevel closed-loop planning. We use the multi-agent box-pushing problem as an example to verify the framework. Within this framework, the upper-level planning (which is used for box position prediction) and the lower-level planning (which is used for agent position allocation) are designed to connect and coordinate between the global and local decisions. The influence of states based on planning creates a closed-loop control mechanism with temporary targets as input, allowing the system to adapt to various environments. In this article, we use webots as the simulation platform to conduct multi-agent box-pushing experiments and compare the results with the rule-based method to demonstrate the effectiveness and advantages of our approach.
Enhancing Bayesian Inference-Based Damage Diagnostics Through Domain Translation With Application to Miter Gates
Authors: Zeng Yichao , Zhao Zhao , Qian Guofeng , Todd Michael D. , Hu Zhen 
Published: January 2025

Abstract
Bayesian inference based on computational simulations plays a crucial role in model-informed damage diagnostics and the design of reliable engineering systems, such as the miter gates studied in this article. While Bayesian inference for damage diagnostics has shown success in some applications, the current method relies on monitoring data from solely the asset of interest and may be affected by imperfections in the computational simulation model. To address these limitations, this article introduces a novel approach called Bayesian inference-based damage diagnostics enhanced through domain translation (BiEDT). The proposed BiEDT framework incorporates historical damage inspection and monitoring data from similar yet different miter gates, aiming to provide alternative data-driven methods for damage diagnostics. The proposed framework first translates observations from different miter gates into a unified analysis domain using two domain translation techniques, namely, cycle-consistent generative adversarial network (CycleGAN) and domain-adversarial neural network (DANN). Following the domain translation, a conditional invertible neural network (cINN) is employed to estimate the damage state, with uncertainty quantified in a Bayesian manner. Additionally, a Bayesian model averaging and selection method is developed to integrate the posterior distributions from different methods and select the best model for decision-making. A practical miter gate structural system is employed to demonstrate the efficacy of the BiEDT framework. Results indicate that the alternative damage diagnostics approaches based on domain translation can effectively enhance the performance of Bayesian inference-based damage diagnostics using computational simulations.