bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: Optical, photo-physical and photo-stability characterizations of malachite green as a laser dye, combined with TD-DFT simulations
Authors: Ghazy Ahmed R. , Abotalb Diana. F. , Kenawy El-Refaie , Ghazy R. , Abdel Gawad Sayed A. 
Published: January 2024

AbstractThe optical properties of Malachite green (Mg) dye were examined experimentally, including absorption, optical energy gab, refractive index, dielectric constant, optical conductivity and emission spectra in various solvents. Additionally, several significant photophysical parameters were evaluated, including the extinction coefficient (ε), the energy yield of fluorescence (Ef), the length of attenuation Λ (λ), oscillator strength (f), quantum yield (Øf), fluorescence lifetime ($${\uptau }_{{\text{f}}}$$

τ
f

), decay rate radiative constant (kr), and the dipole moment (μ) in addition to absorption and emission cross-sections (σa) and (σe) respectively. Time Dependent Density function theory (TD-DFT) computations were used to generate the theoretical absorption spectra of the (Mg) compound. The energy gap (Eg), electron density, and electrostatic potential were also simulated.
Physische Attraktivität und Lebenszufriedenheit
Authors: Rosar Ulrich , Althans Roman , Krause Johannes 
Published: January 2024

ZusammenfassungZiel dieses Beitrags ist es, den Einfluss der physischen Attraktivität auf unterschiedliche Aspekte der Lebenszufriedenheit empirisch zu überprüfen. Dies wird auf Basis theoretischer Überlegungen mit den Daten aus dem Kölner Gymnasiasten-Panel geprüft, das die private sowie die berufliche Situation der Befragten im modalen Alter von 30, 43, 56 und 66 Jahren abbildet. Für einen Teil der Befragten wurde im Nachhinein die physische Attraktivität im Alter von 16 Jahren ermittelt. Unter Kontrolle des Berufsprestiges, des Erwerbsstatus, der Wochenarbeitszeit und dem Vorliegen von Arbeitslosigkeit wird ein signifikanter Attraktivitätseffekt auf die berufliche Lebenszufriedenheit im Alter von 30 Jahren nachgewiesen. In Bezug auf die private Lebenszufriedenheit findet sich kein substanzieller Attraktivitätseffekt. Nichtsdestotrotz besitzt die physische Attraktivität im Alter von 16 Jahren einen signifikanten Effekt auf die allgemeine Lebenszufriedenheit im Alter von 30 und 43 Jahren unter Kontrolle der privaten und beruflichen Lebenszufriedenheit. Der Effekt im Alter von 43 Jahren bleibt auch dann bestehen, wenn für die allgemeine Lebenszufriedenheit im Alter von 30 Jahren kontrolliert wird. Mit dieser Untersuchung wird also ein langfristiger Effekt der äußeren Erscheinung auf verschiedene Aspekte der Lebenszufriedenheit nachgewiesen. Insbesondere der Einfluss auf die allgemeine Lebenszufriedenheit sei herausgestellt. Hier besitzt die physische Attraktivität einen fast drei Dekaden währenden, die Zufriedenheit steigernden Nachhall.
Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells
Authors: Yanagihara Kana , Hayashi Yohei , Liu Yujung , Yamaguchi Tomoko , Hemmi Yasuko , Kokunugi Minako , Yamada Kozue Uchio , Fukumoto Ken , Suga Mika , Terada Satoshi , Nikawa Hiroki , Kawabata Kenji , Furue Miho 
Published: January 2024

AbstractTrisomy 12 is one of the most frequent chromosomal abnormalities in cultured human pluripotent stem cells (hPSCs). Although potential oncogenic properties and augmented cell cycle caused by trisomy 12 have been reported, the consequences of trisomy 12 in terms of cell differentiation, which is the basis for regenerative medicine, drug development, and developmental biology studies, have not yet been investigated. Here, we report that trisomy 12 compromises the mesendodermal differentiation of hPSCs. We identified sublines of hPSCs carrying trisomy 12 after their prolonged culture. Transcriptome analysis revealed that these hPSC sublines carried abnormal gene expression patterns in specific signaling pathways in addition to cancer-related cell cycle pathways. These hPSC sublines showed a lower propensity for mesendodermal differentiation in embryoid bodies cultured in a serum-free medium. BMP4-induced exit from the self-renewal state was impaired in the trisomy 12 hPSC sublines, with less upregulation of key transcription factor gene expression. As a consequence, the differentiation efficiency of hematopoietic and hepatic lineages was also impaired in the trisomy 12 hPSC sublines. We reveal that trisomy 12 disrupts the genome-wide expression patterns that are required for proper mesendodermal differentiation.
Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred©) tool
Authors: Roche-Lima Abiel , Rosado-Quiñones Angélica M. , Feliu-Maldonado Roberto A. , Figueroa-Gispert María Del Mar , Díaz-Rivera Jennifer , Díaz-González Roberto G. , Carrasquillo-Carrion Kelvin , Nieves Brenda G. , Colón-Lorenzo Emilee E. , Serrano Adelfa E. 
Published: January 2024

Abstract
Purpose
Antimalarial drug resistance is a global public health problem that leads to treatment failure. Synergistic drug combinations can improve treatment outcomes and delay the development of drug resistance. Here, we describe the implementation of a freely available computational tool, Machine Learning Synergy Predictor (MLSyPred©), to predict potential synergy in antimalarial drug combinations.

Methods
The MLSyPred© synergy prediction method extracts molecular fingerprints from the drugs’ biochemical structures to use as features and also cleans and prepares the raw data. Five machine learning algorithms (Logistic Regression, Random Forest, Support vector machine, Ada Boost, and Gradient Boost) were implemented to build prediction models. Implementation and application of the MLSyPred© tool were tested using datasets from 1540 combinations of 79 drugs and compounds biologically evaluated in pairs for three strains of Plasmodium falciparum (3D7, HB3, and Dd2).

Results
The best prediction models were obtained using Logistic Regression for antimalarials with the strains Dd2 and HB3 (0.81 and 0.70 AUC, respectively) and Random Forest for antimalarials with 3D7 (0.69 AUC). The MLSyPred© tool yielded 45% precision for synergistically predicted antimalarial drug combinations that were annotated and biologically validated, thus confirming the functionality and applicability of the tool.

Conclusion
The MLSyPred© tool is freely available and represents a promising strategy for discovering potential synergistic drug combinations for further development as novel antimalarial therapies.
Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?
Authors: Surma Stanisław , Sahebkar Amirhossein , Banach Maciej 
Published: January 2024

Abstract
Purpose of Review
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of premature death. Lipid disorders, particularly elevated serum low-density lipoprotein cholesterol (LDL-C), contribute significantly to ASCVD. The risk of developing ASCVD is influenced by the duration of exposure to elevated LDL-C concentrations (cholesterol-years concept). Implementing lipid-lowering treatments based on the principles of “the earlier the better,” “the lower the better,” and “the longer the better” has been shown to reduce cardiovascular risk and significantly extend lifespan. Despite the availability of numerous lipid-lowering drugs, achieving satisfactory control of lipid disorders remains very challenging. Therefore, there is a need for novel approaches to improve treatment adherence.

Recent Findings
One promising solution under investigation is the development of an anti-PCSK9 vaccine, which could be administered annually to provide long-term control over LDL-C concentrations. Experimental studies and the sole clinical trial conducted thus far have demonstrated that the anti-PCSK9 vaccine induces a durable immune response associated with lipid-lowering and anti-atherosclerotic effects. Furthermore, it has exhibited good tolerability and a satisfactory safety profile. However, we still need data from phase 2, 3, and cardiovascular outcome trial to confirm its safety and efficacy and add value in the armamentarium of available and perspective lipid-lowering drugs.

Summary
This article highlights the significance of developing an anti-PCSK9 vaccine and provides an overview of the current knowledge on various anti-PCSK9 vaccines.
Disentangling the solar activity–solar wind predictive causality at Space Climate scales
Authors: Reda Raffaele , Stumpo Mirko , Giovannelli Luca , Alberti Tommaso , Consolini Giuseppe 
Published: January 2024

AbstractThe variability in the magnetic activity of the Sun is the main source of the observed changes in the plasma and electromagnetic environments within the heliosphere. The primary way in which solar activity affects the Earth’s environment is via the solar wind and its transients. However, the relationship between solar activity and solar wind is not the same at the Space Weather and Space Climate time scales. In this work, we investigate this relationship exploiting five solar cycles data of Ca II K index and solar wind parameters, by taking advantage of the Hilbert–Huang Transform, which allows to separate the contribution at the different time scales. By filtering out the high-frequency components and looking at decennial time scales, we confirm the presence of a delayed response of solar wind to Ca II K index variations, with a time lag of $$\sim$$
∼
3.1-year for the speed and $$\sim$$
∼
3.4-year for the dynamic pressure. To assess the results in a stronger framework, we make use of a Transfer Entropy approach to investigate the information flow between the quantities and to test the causality of the relation. The time lag results from the latter are consistent with the cross-correlation ones, pointing out the presence of a statistical significant information flow from Ca II K index to solar wind dynamic pressure that peaks at time lag of 3.6-year. Such a result could be of relevance to build up a predictive model in a Space Climate context.
Beyond the basics: a perspective on barriers and opportunities for scaling up biochar production from forest slash
Authors: Pierson Derek , Anderson Nathaniel , Brewen Jessica , Clark Nehalem , Hardy Margaret C. , McCollum Daniel , McCormick Frank H. , Morisette Jeffrey , Nicosia Timothy , Page-Dumroese Deborah , Rodriguez-Franco Carlos , Tirocke Joanne 
Published: January 2024

AbstractBiochar production from woody biomass generated during forest management (slash) offers significant benefits for soil health and carbon emissions, yet its adoption remains limited in the western United States (U.S.). To address this challenge, the U.S. Department of Agriculture (U.S.D.A.) Forest Service Rocky Mountain Research Station organized two workshops focused on forest management-centric biochar production. These workshops convened a diverse group of stakeholders, including investors, land management practitioners, industry professionals, and research scientists, each with unique roles in slash-based biochar production. This article presents a synthesis of the insights and perspectives gathered from these workshops, aiming to identify barriers and propose viable pathways for overcoming them. The barriers encompass governance issues such as policy and permitting, economic challenges related to costs, funding, and market stability, technological hurdles concerning methods and equipment, and a need for further research and improved science dissemination. In response to these challenges, workshop attendees collaboratively outlined specific strategies to reduce these barriers. These strategies emphasize the expansion of operational initiatives, the development of proactive policies, the stabilization of biochar markets, and the generation of additional case studies showcasing the effects of biochar amendments across various soils and environments. Collectively, the insights gleaned from this workshop series provide a comprehensive roadmap outlining both the struggles and the necessary actions and investments required to enhance the scale of slash-based biochar production and application in the western U.S.
Graphical Abstract
A Glimpse into Gynecologic Practice During the Islamic Golden Age
Authors: Fadel Hossam E. , Al-Hendy Ayman 
Published: January 2024

AbstractThe Islamic Golden Age was the time in history from eighth to fourteenth century. This era was marked by expansion of Islamic world to all the Middle East, North Africa, South and East Europe, and Central Asia. The Islamic world was the wealthiest region in the world at that time and that wealth was utilized to promote great flourishing in the arts, philosophy, science, and medicine. The practice of healing was considered the most noble of human undertakings by Islamic scholars. In this era, many great physician-scientists emerged in the Islamic world, albeit several were not Muslims, who examined prior writings, corrected many, and proceeded to produce their own observations and innovations. This article highlights some of the most important contributions to gynecology of some prominent scholars during this shining phase of medical history.
Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves
Authors: Carrillo-Jaimes Karol , Fajardo-Hernández Carlos A. , Hernández-Sedano Fernanda , Cano-Sánchez Patricia , Morales-Jiménez Jesús , Quiroz-García Beatriz , Rivera-Chávez José 
Published: January 2024

AbstractAntimicrobial resistance is emerging as a global health challenge that requires immediate and concerted attention. Accordingly, the WHO has issued alerts urging to continue developing antibiotics with novel mechanisms of action toward clinically important pathogens, including Acinetobacter baumannii. In this context, fungi have played a crucial role in the discovery and development of antibiotics. Therefore, in this work, three fungal strains were prioritized based on their metabolic profiles and antibacterial activity against a pan-resistant isolate of A. baumannii, to identify potential antibiotic molecules. Chemical investigation of the selected fungi (mangrove endophytes) led to the isolation of asperazine (1), aurasperone B (2), aurasperone F (3), TMC-256A1 (4), fonsecin B (5), dianhydroaurasperone C (6), aurasperone A (7), pyrophen (8), and penicillide (9). Moreover, an in vitro assay to detect ligands of the filamentous temperature-sensitive mutant Z enzyme of A. baumannii (AbFtsZ), a GTPase that plays a central role in bacterial division, was developed to correlate the antibacterial properties of the isolated molecules to a mechanism of action. Compounds 1–4 and 9 inhibited the growth of A. baumannii. Interestingly, compounds 2, 3, and 5–9 interacted with AbFtsZ1-412, increasing its GTPase activity. Conversely, compound 4 exhibited an outstanding ability to act as an inhibitor of both the enzymatic activity and the growth of the strain under study.
Graphical Abstract
Phonon thermal transport in bilayer polycrystalline graphene nanoribbons: effects of interlayer interaction, grain size, and vacancy defects
Authors: Yang Zi-Qiang , Shakoori Muhammad Asif , Li Hai-Peng 
Published: January 2024

AbstractIn this paper, molecular dynamics simulations have been employed to investigate the phonon thermal transport in bilayer polycrystalline graphene nanoribbon (pGNR/pGNR), compared with bilayer graphene nanoribbon (GNR/GNR) and pGNR/GNR heterostructure. The interfacial thermal resistance (ITR) of bilayer structures was also calculated using the heat dissipation method. The effects of interlayer interaction, grain size, and vacancy defects on ITR and in-plane phonon thermal conductivity of bilayer structures were investigated. It was found that the ITR as well as in-plane phonon thermal conductivity of pGNR/pGNR was less than that of pGNR/GNR and much less than that of GNR/GNR, for the same size. For the studied bilayer structures, both the ITR and in-plane phonon thermal conductivity decrease with increasing interlayer interactions. Moreover, ITR increases with increasing grain area size whereas decreases with increasing vacancy defects in pGNR-based bilayers. The introduction of pGNR interface roughness and vacancy defects results in an enhanced phonon coupling in pGNR-based bilayers compared to pure GNR/GNR bilayers. Presented simulation investigations will help to understand the interlayer thermal transport properties of polycrystalline graphene and provide essential guidance for experimentally regulating phonon thermal transport between layers of polycrystalline graphene.
The first 30 min hidden aftershocks of the 2022 September 17, ML 6.4, Guanshan, Taiwan earthquake and its seismological implications
Authors: Huang Bor-Shouh , Ku Chin-Shang , Lin Chin-Jen , Lee Shiann‐Jong , Chen Yen-Ling Eileen , Jiang Juen-Shi , Sun Wei-Fang 
Published: January 2024

AbstractThe first 30 min of the aftershock sequence following the 2022 September 17, ML 6.4, Guanshan, Taiwan earthquake is investigated by the back-projection (BP) method. Based on the Automatic Gain Control (AGC) to process individual earthquake record and sort waveforms by epicentral distance, 80 events are identified near the Guanshan earthquake epicenter to verify its temporal variation. However, most of these events cannot clearly image by the BP method to determine its spatial locations for its small amplitude and short time separation. In total, 29 aftershocks are imaged by this study to identify its spatial locations during this time period. The relocated events are compared with the Central Weather Bureau (CWB) rapid report catalogue. Only 5 events have been reported by the CWB rapid report catalogue. These unreported hidden aftershocks are identified to distribute surrounding the epicenter and extended to the east. This extracted information of hidden aftershocks is crucial for assessing the potential for future large aftershocks and estimating the associated seismic hazards in a given region, and provide extra message to evaluate the source physics in general.
Developing a social sensing index for monitoring place-oriented mental health issues using social media (twitter) data
Authors: Park Jaehee , Tsou Ming-Hsiang , Nara Atsushi , Cassels Susan , Dodge Somayeh 
Published: January 2024

AbstractResearch shows that certain external factors can affect the mental health of many people in a community. Moreover, the importance of mental health has significantly increased in recent years due to the COVID-19 pandemic. Many people communicate and express their emotions through social media platforms, which provide researchers with opportunities to examine insights into their opinions and mental state. While social sensing studies using social media data have flourished in the last decade, many studies using social media data to detect and predict mental health status have focused on the individual level. In this study, we aim to generate a social sensing index for mental health to monitor emotional well-being, which is closely related to mental health, and to identify daily trends in negative emotions at the city level. We conduct sentiment analysis on Twitter data and compute entropy of the degree of sentiment change to develop the index. We observe sentiment trends fluctuate significantly in response to unusual events. It is found that the social sensing index for mental health reflects both city-wide and local events that trigger negative emotions, as well as areas where negative emotions persist. The study contributes to the growing body of research that uses social media data to examine mental health at a city-level. We focus on mental health at the city-level rather than individual, which provides a broader perspective on the mental health of a population. Social sensing index for mental health allows public health professionals to monitor and identify persistent negative sentiments and potential areas where mental health issues may emerge.
The effects of a surgical mask and an N95 mask on intelligibility of explicit and ambiguous speech produced in the operating room environment
Authors: Ishido Hidemi , Oishi Rieko , Yamazaki Yuki , Inoue Satoki 
Published: January 2024

Abstract
Purpose
We investigated the effects of a surgical mask and an N95 mask on speech intelligibility using explicit and ambiguous sentences in Japanese. In addition, the effects of background noise specific to an operating room environment on the speech intelligibility of these sentences were also investigated.

Methods
We created 20 sets of five sentences; 10 sets consisting of explicit words, and 10 containing ambiguous words. Each set was recorded by a speaker while wearing a surgical mask or an N95 mask, combined with a face shield. A total of four combinations of speech data were created. Each subject was asked to listen to one set from each of the four combinations and write down the speech. The test was performed in normal background noise as well as in noise levels of 50, 60, and 70 dB.

Results
Twenty-eight volunteers were included in this study. In the tests for explicit sentences, intelligibility of speech with an N95 mask was significantly lower than that with a surgical mask in the presence of 60 dB noise. As for explicit sentences produced with a surgical mask, intelligibility was significantly decreased in the presence of 70 dB noise. Regarding explicit sentences produced with an N95 mask, intelligibility was significantly decreased in the presence of 60 and 70 dB noise. In the tests for ambiguous sentences, intelligibility of speech produced with an N95 mask was not significantly lower than that with a surgical mask at all noise levels. As for ambiguous sentences produced with a surgical mask, no significant decrease in intelligibility was observed at any noise level. Regarding ambiguous sentences produced with an N95 mask, intelligibility was significantly decreased in the presence of 60 and 70 dB noise.

Conclusion
Speech intelligibility was impaired both with a surgical mask and an N95 mask in the normal background noise specific in an operating room during surgery, even if the speech consisted of explicit words. The impairment of speech intelligibility was significantly exacerbated with the use of ambiguous language and in the background noise typical in an operating room environment. Speech intelligibility was further reduced with the use of an N95 mask.

Trial Registration
Registered at the University Hospital Medical Information Network Clinical Trials Registry on March 7, 2023 (UMIN R000050373).
Mandatory Human Rights Due Diligence (mHRDD) Laws Caught Between Rituals and Ritualism: The Forms and Limits of Business Authority in the Global Governance of Business and Human Rights
Authors: Lichuma Caroline Omari 
Published: January 2024

AbstractThis article utilizes a ‘rituals-ritualism’ framework to assess the perils and potentials of relying upon mandatory human rights due diligence (mHRDD) laws to regulate the behaviour of transnational corporations (TNCs). This framework offers a socio-legal perspective that seeks to show how law is both influenced by and influences the social context within which it operates, i.e., the socially embedded operation of law.1 It has been advanced as a useful rubric for assessing whether and how states comply with human rights treaties,2 but can be extended to an assessment of mHRDD laws. Ultimately, this article hypothesizes that the potential regulatory effectiveness of mHRDD laws hinges on the extent to which HRDD obligations are transformed into rituals akin to cultural norms. In the absence of such a transformation, ritualism in HRDD will only further entrench a problematic status quo that has allowed TNCs to externalize the human rights and environmental impacts of their activities.