bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 13315: Recurrent Cardiac Tamponade Due to Minoxidil Associated Drug Induced Lupus Erythematosus
Authors: Juarez Michel , Benjanuwattra Juthipong , Herrera Ramos Alejandro , Iskandir Marina , Ansari Mohammad , Shurmur Scott W 
Published: December 2023

Case description A 59 year old man with history of MGUS, CKD stage 2, DM, HTN, and OSA presented with gradual worsening of dyspnea and intermittent dizziness over the past few days. Echocardiography showed diastolic collapse of the RV, RA collapse, IVC plethora, marked tricuspid in-flow velocities, and pericardial effusion suggestive of cardiac tamponade (CT). Subxiphoid pericardial window was emergently performed. Serosanguineous fluid 900 mL was drained, and fluid analysis was negative for malignancy or infection. Pericardial biopsy revealed fibro-connective tissue with mild peri-vascular chronic inflammation. He significantly improved and was discharged after 5 days.
One month later, he presented again with 1 day symptom of severe dyspnea due to recurrent pericardial effusion with CT physiology. Emergent pericardiocentesis was performed to remove 1,800 ml of serous fluid. Serologic workup for autoimmune disease was strongly positive for anti-histone antibody. ESR (124 mm/hr) and c-reactive protein (5.8 mg/dL) were elevated. Upon review of prescription list, he had been treated for HTN in the past 5 years with minoxidil, amlodipine, lisinopril, and carvedilol.
Discussion The use of topical minoxidil, a potent peripheral arterial vasodilator, has been approved for androgenetic alopecia in both men and women for decades, whereas oral minoxidil is limited to refractory hypertension due to side effects such as reflex tachycardia, fluid retention, hypertrichosis, and, rarely, idiosyncratic pericardial effusion.
Pericardial effusion was reported in approximately 3-5% of patients receiving minoxidil therapy, which could be attributed to volume overload associated with underlying renal insufficiency. Besides hydralazine, another direct arterial vasodilator commonly implicated in drug-induced lupus erythematosus (DILE), minoxidil also carries a trivial risk of DILE, as suggested by a positive anti-histone antibody and biopsy-proven serositis.
Although the association between topical minoxidil and pericardial effusion has never been reported, receding hairline has become a major cosmetic concern and the clinicians should be aware of this rare, but serious, complication associated with minoxidil due to its widespread use.
Abstract 14201: Double the Trouble: Extremely Rare Incidental Finding of a Double Interatrial Septum With Atrial Septal Aneurysm and Coexisting Patent Foramen Ovale
Authors: Bharani Vishnu , Tang Kevin , Krishnam Kavin , Urgun Deniz , Naqvi Ali 
Published: December 2023

Case:
A 59-year-old&nbsp;female with a past medical history of hypothyroidism and IgG deficiency presents to cardiology clinic due to palpitations and premature ventricular complexes (PVCs) noted at a recent urgent care visit. In-office vitals, physical exam, labs, and EKG were unremarkable. Ambulatory cardiac monitoring showed predominantly sinus rhythm with a PVC burden of 1.4%. Echocardiogram revealed an extremely rare structural anomaly – a double interatrial septum (DIAS) with atrial septal aneurysm.

Cardiac MRI (cMRI) further confirmed the presence of a DIAS enclosing an interatrial space, along with blood flow within the interatrial space and a discontinuity in the anterior right lateral atrial septum suggestive of a patent foramen ovale (PFO). There was no evidence of thrombus within the interatrial or intracardiac spaces. Mild right atrial enlargement was seen. The patient was initiated on aspirin for cardioembolic stroke prophylaxis.

Discussion:
DIAS is a highly rare congenital cardiac anomaly with limited number of cases in literature. It has been described as a midline third atrium resulting in a “tri-atrial heart”. As of 2018, less than 20 cases have been cited. DIAS is characterized by two parallel interatrial septa along with a clear echo lucent midline space that expands in systole and collapses in diastole. This case is unique as it is one of the few to include additional characterization with cMRI.

Patients with DIAS are usually asymptomatic but can experience cardioembolic events as the interatrial space is at risk for thrombus formation. Communication across the DIAS makes these events more likely. Unlike with atrial fibrillation/flutter, no current criteria for anticoagulation (AC) initiation exists for DIAS given the scarcity of cases. While some sources advocate for use of anti-platelet agents, others have indicated a preference for oral AC.
Our patient had an interatrial space and a PFO but lacked communication across the DIAS, had low bleeding risk, and no other classic risk factors of Virchow’s triad. We determined her risk for thrombus formation to be relatively low, and thus initiated her on aspirin over oral AC. Percutaneous closure of the interatrial space was deferred as it has been dismissed as a viable treatment option in the literature.
Abstract 14216: Acute Heart Failure and Mitral Stenosis in a Patient With Spindle Cell Sarcoma of the Mitral Valve
Authors: Ormachea Kori , Cranston Ariana , Khadilkar Arjun , Quintero Bisono Janina , George Bistees 
Published: December 2023

A 27-year-old male with no past medical history presented with a productive cough, intermittent hemoptysis, dyspnea, orthopnea, and lower extremity edema. He underwent an echocardiogram that was significant for a large 6.2 cm x 3.5 cm left atrial mass moving into the left ventricle across the mitral valve concerning for a myxoma. Other pertinent findings were an ejection fraction of 50-55%, severe mitral stenosis with a mean mitral valve gradient of 23, severely reduced right heart function, and severe tricuspid regurgitation. Cardiovascular surgery was consulted for evaluation of atrial mass. He underwent left atrial mass resection. The left atrial mass was attached to the mitral valve, so the mitral valve was repaired with Onyx mechanical valve. After the surgery, there was a significant improvement in right heart function, mitral valve gradient, and velocities were within the expected range. Pathology from atrial mass back with high-grade spindle cell sarcoma so Oncology was consulted. Further studies were negative for metastatic spread. He was started on adjuvant chemotherapy and currently, he is undergoing his fourth cycle. Follow-up TEE six months later noted a left atrial mass located in or where the left atrial appendage should be approximately that was 2.5cm x 1.5cm concerning for recurrence of his sarcoma.
This case demonstrates a rare primary cardiac tumor, spindle cell sarcoma, which is generally aggressive and therefore has a poor prognosis. The clinical symptoms are more related to the location of the sarcoma than the histopathology. Depending on location, cardiac sarcomas generally present with heart failure as in this patient. About 25% of cardiac tumors are malignant with the majority of those being sarcomas. Initial evaluation of primary cardiac sarcomas should include echocardiography. The primary treatment is surgical resection of the mass with adjuvant chemotherapy, however, there is a high rate of recurrence and metastatic spread.
Abstract 16562: Subclinical Flow Inefficiencies in Non-Obstructive Hypertrophic Cardiomyopathy Subgroups Revealed by 4D Flow Cardiovascular Magnetic Resonance
Authors: Pola Karin , Ashkir Zakariye , Myerson Saul G , Arheden Håkan , Watkins Hugh , Neubauer Stefan , Arvidsson Per M , Raman Betty 
Published: December 2023

Background
Patients with non-obstructive hypertrophic cardiomyopathy (nHCM) may exhibit flow inefficiencies despite normal flow profiles on transthoracic echocardiogram. We investigated whether left ventricular (LV) kinetic energy (KE) and hemodynamic forces (HDF) on 4D flow CMR are abnormal in nHCM, and examined the impact of genotype and hypertrophy phenotype on flow profiles.

Methods
90 participants (70 HCM without echocardiographic outflow tract obstruction and 20 healthy controls) underwent 4D flow CMR. Patients were categorized as phenotype positive (P+) if they had LV hypertrophy (≥15mm or ≥13mm with an HCM family history), or phenotype negative (P-) referring to pre-hypertrophic pathogenic sarcomeric variant carriers. LV KE, HDF and transversal/longitudinal HDF ratio were computed from 4D flow CMR.

Results
P+ patients and controls were of similar age, but P- were younger. P+, P- and controls had comparable LV ejection fraction on CMR, and LV outflow tract pressure gradients and diastolic velocities on echocardiography (Table 1).

Systolic KE was higher in P+ compared to controls (Table 1, Figure 1). Early diastolic KE was higher in P- than P+, reflecting younger P-, but did not differ between P+ and controls. Late diastolic KE was higher in P+ versus P- and controls.
Systolic HDF ratio was higher in P+ than controls (Table 1, Figure 1). Diastolic HDF and HDF ratio were similar between P+ and controls.

Conclusion
Despite comparable flow velocities on echocardiography, nHCM exhibited higher systolic KE and HDF ratio, and late diastolic KE on 4D flow CMR relative to controls. Both the extent and pattern of hypertrophy are important determinants of abnormalities in KE and HDF.
BIKAS: Bio-Inspired Knowledge Acquisition and Simulacrum—A Knowledge Database to Support Multifunctional Design Concept Generation
Authors: Velivela Pavan Tejaswi , Zhao Yaoyao Fiona 
Published: December 2023

ABSTRACT
A detailed acquisition, analysis, and representation of biological systems exhibiting different functions is required to develop unique bio-inspired multifunctional conceptual designs and methods. This paper presents BIKAS: Bio-inspired Knowledge Acquisition and Simulacrum, a knowledge database of biological systems exhibiting various functionalities, developed based on case-based bio-inspired examples from literature. The knowledge database represents the biological features, their characteristics, and the function exhibited by the biological feature as a combination of its integrated structure and structural strategy. Furthermore, this knowledge database is utilized by the Expandable Domain Integrated Design (xDID) model that works on classifying, mapping, and representing biological features into their respective geometric designations called Domains. The combination of features from the Domains results in the generation of multifunctional conceptual designs. In addition, Meta-level design factors are proposed to aid designers in filtering the biological features and their respective functions having a similar structural strategy, thus aiding designers in rapidly selecting and emulating biological functions.
Alligatorascension: climbing performance of Alligator mississippiensis
Authors: Swords Annelise , Cramberg Michael , Parker Seth , Scott Anchal , Sopko Stephanie , Taylor Ethan , Young Bruce A. 
Published: December 2023

Abstract
In tetrapedal locomotion, whether horizontal or during climbing, interactions between the foot and the contact surface or substrate influence the locomotor performance. Multiple previous studies of tetrapedal squamates (lizards) have reported that the animals used the same locomotor velocity, regardless of the angle of ascension. The present study was performed to determine if the American alligator (Alligator mississippiensis) would exhibit a stable climbing velocity and to determine to what degree, if any, this climbing velocity could be modified by substrate differences. Sub-adult Alligator mississippiensis, with body lengths around 170 cm, used the same stride velocity when moving at angles of 0°, 30°, and 55°. During these trials, both the sub-adult and juvenile alligators used a “low walk” gait, rather than a distinctive climbing gait. When the alligators traversed an open grate, their stride duration increased (and stride velocity decreased) presumably due to the insertion (and retraction) of their claws and digits into the grate. When climbing at 55° the juvenile and sub-adult alligators used the same stride duration; the sub-adults used a stride length that was significantly larger in absolute terms, but significantly shorter in relative terms. Despite their large size, and their more caudal center of mass, the climbing performance of Alligator mississippiensis is similar to what has been described in the previously-studied tetrapedal squamates.
Exempla in 1 Maccabees and Josephus’ Bellum Judaicum: Doing Jewish Exemplarity in the Greco-Roman World
Authors: Bay Carson , van Henten Jan Willem 
Published: December 2023

Abstract
The study of exempla and exemplarity in Mediterranean antiquity touches the methodological borderlines and interest areas of several distinct academic disciplines. Earlier studies focused on semantics and the development from the Greek παράδειγμα to the Roman exemplum. More recently, the field of Classics has tended to examine exemplarity as a phenomenon with a distinctively Roman edge. At the same time, scholars in adjacent disciplines like ancient Judaism and early Christianity have engaged Classics scholarship on this topic in their own work. This paper extends this arena by clarifying aspects of exemplarity within two paradigmatic texts of Hellenistic- and Roman-era Judaism. We examine 1 Maccabees 2:49–68 and Josephus’ Jewish War 6.99–110, both speeches set within “contemporary” histories written by Jewish authors. By examining these ancient Jewish passages, written within the Greco-Roman world, we help add clarity and meaning to what could be “Jewish” about exemplarity in ancient Mediterranean contexts.
Textiles in the Funerary chaîne opératoire. Perspectives from Meroitic and Postmeroitic Sudan and Nubia (c.350 BCE–550 CE)
Authors: Yvanez Elsa 
Published: December 2023

Abstract
This paper exploits the rich but little-studied corpus of archaeological textiles found in modern Sudan and Nubia and dated to the Meroitic and Postmeroitic periods (c.350 BCE–550 CE). It allies current approaches developed in the field of mortuary archaeology with an in-depth analysis of textile artefacts discovered in situ in the graves of the ancient Sudanese people. Going beyond the simple description of textile items and their potential place in the tomb, the concept of funerary chaîne opératoire is used to trace and interpret textile gestures around the deceased. Through many examples and the detailed case study of an ‘archer’ grave from Gebel Adda (Lower Nubia), this article aims at demonstrating the active and important role of textiles in the transformation of the dead, from an inert body to a revered ancestor.
Biblical Call and Classical Response: Intertextuality and Image-Text Relations in Henricus Engelgrave’s Sermon Books
Authors: Reddemann Lukas 
Published: December 2023

Abstract
This paper aims to explore the unique structure and function of the emblems in Henricus Engelgrave’s (1610–70) sermon books (Lux evangelica, Caeleste pantheon, and Caelum empyreum). The emblems serve as introductions to sermons for Sundays and feast days of the liturgical year; they include two mottos: one biblical quotation and a quotation from classical Roman poetry. Based on a selection of exemplary emblems, this paper demonstrates that the second mottos are not merely decorative additions, as has sometimes been argued. Rather, they constitute key features in Engelgrave’s emblematic conception as they provide allegorical and pictorial imageries that affect the picturae of the emblems, the expression of the moral purpose of the sermons, and the relationship between both. This article is part of the special issue of the Journal of Jesuit Studies on Jesuit emblems and emblematic edited by Walter S. Melion.
Ménestrier on Emblems in the Context of “Erudite Images” and His Wider “Philosophy of Images”
Authors: Loach Judi 
Published: December 2023

Abstract
This paper shows how Ménestrier’s theorizing on emblems developed from his practice as devisor of decorative schemes and festivals, as indeed did that of fellow Jesuits. It explains his concern for developing a theoretical framework (whereas fellow Jesuits usually published collections of emblems with little theory) in terms of the influence exerted by his Jesuit training in Aristotelian philosophy and Thomist theology and the example set by the (ex-)Jesuit theorist Emanuele Tesauro. It puts Ménestrier’s theory and practice of emblems within the context of his more general concern for “erudite,” or symbolic, images and how he conceived such images, in general, operate on humans. In conclusion, I suggest how this understanding of such images’ potential within the context of Catholic renewal affects how Ménestrier understands the purpose and creation of emblems. This article is part of the special issue of the Journal of Jesuit Studies on Jesuit emblems and emblematic edited by Walter S. Melion.
Interactive effects of temperature and substrates on selected life history parameters of the African palm weevil Rhynchophorus phoenicis (Fabricius) (Coleoptera: Curculionidae)
Authors: Anankware J.P. , Debrah S.K. , Asomah S. , Egonyu J.P. , Eilenberg J. , Roos N. , Obeng-Ofori D. 
Published: December 2023

Abstract
The African palm weevil Rhynchophorus phoenicis (Fabricius) is an alternative to conventional protein sources from livestock and poultry due to their rich nutritional content and ability to be reared on agricultural by-products. When establishing a production protocol for mass production of R. phoenicis larvae, it is imperative to understand the interaction between substrate and temperature on the development and reproductive success of the weevils. To determine the optimum temperatures for continuous production of R. phoenicis, the larvae were subjected to four temperatures (20 °C, 25 °C, 30 °C, and 35 °C) at a relative humidity of 70% on different substrates (elephant ear corm, peeled sugarcane, and palm yolk) in an incubator. The developmental duration of R. phoenicis larvae decreased with a temperature above 30 °C whilst percentage larval survival was high at 20 °C and 25 °C. The temperature with the fastest larval development and highest mortality was 35 °C. The optimal temperature from egg to the adult stage was observed at 25 °C. The oviposition and hatchability of eggs was high on elephant ear corm (EC), and palm yolk (PY) at 25 °C whilst the number of cocoons was high at 20 °C on decorticated coconut coir (DC).
Thus, it is feasible to utilise the easily accessible substrates that interact well with temperature to produce optimum condition for the production of R. phoenicis larvae.
Farmed yellow mealworm (Tenebrio molitor; Coleoptera: Tenebrionidae) welfare: species-specific recommendations for a global industry
Authors: Barrett M. , Godfrey R.K. , Schnell A. , Fischer B. 
Published: December 2023

Abstract
Yellow mealworms (Tenebrio molitor; Coleoptera: Tenebrionidae) are currently the most farmed holometabolous insect species in the insects as food and feed industry, with over 300 billion individual mealworms reared annually. Yellow mealworm larvae are being developed for potential uses as human protein, pet, livestock and fish feed, reclamation of mycotoxin-contaminated grains, and more. Insect welfare is of great interest to consumers, producers, and academics; yet no studies have considered the species-specific welfare concerns of farmed yellow mealworms under current industry conditions. Following a model for considering farmed insect welfare, we review yellow mealworm biology and its relationships to welfare in commercial rearing facilities, including: interspecific interactions (predators, parasites, and pathogens), abiotic conditions (temperature, hydration, atmospheric gasses, lighting), nutrition (including pollutants, plastics, and hormones), intraspecific concerns (genetics, morphological defects, cannibalism, density, mating and oviposition needs, and handling-associated stress), and slaughter and depopulation methods (including anesthesia and stunning). From this review, we identify practical recommendations for improving current welfare concerns in the industry and mitigating future concerns that may appear as the industry continues to grow. Finally, we discuss future research directions that are necessary to better understand the welfare of this species.
A List in Three Dimensions
Authors: Wallraff Martin 
Published: December 2023

Wallraff examines the canon tables of the gospels, composed by Eusebius of Caesarea in the first half of the fourth century CE, as a new form of synopsis: a list in three dimensions which uses both the extension (length and breadth) of a page in a codex, and the hypertextuality within the codex (intratextual references back and forth). In the antique culture of the book, this system raises the list to a new level of complexity. Given the extraordinary success of the device (with many hundreds of extant copies in numerous languages), the impact on viewing habits and textual practices was enormous.
Medical treatment of pleural infection: antibiotic duration and corticosteroid usefulness
Authors: Skouras Vasileios , Chatzivasiloglou Foteini , Iliopoulou Marianthi , Rimpa Theofani 
Published: December 2023

The data about the optimal duration of antibiotics and the usefulness of corticosteroids in the management of parapneumonic effusion and pleural infection are scarce. Two randomised controlled trials evaluating short antibiotic courses (ODAPE and SLIM) and another trial assessing the benefit from corticosteroid use (STOPPE) in this setting were recently published. The aim of this journal club is to present these trials and discuss their significance and limitations. ODAPE compared the efficacy and safety of a short (2 weeks)versusan extended (3 weeks) course of amoxicillin–clavulanate in community-acquired complicated parapneumonic effusions, while SLIM compared the efficacy and safety of short (14–21 days)versuslonger (28–42 days) antibiotic courses in patients with community- or hospital-acquired pleural infection. STOPPE assessed the benefit from dexamethasone use in patients with community-acquired pneumonia and concomitant pleural effusion. Both ODAPE and SLIM found that shorter antibiotic courses produce less adverse events while being equally efficacious to the longer courses in a subgroup of patients, such as those with pleural infection that is stabilised with only medical treatment and does not require surgery. In contrast, STOPPE found no benefit from the use of dexamethasone in unselected patients with pneumonia and pleural effusion. Due to the significant limitations of these trials, further studies are required to confirm these findings.Commentary on:Hassan M,et al. The ShortversusLong Antibiotic Course for Pleural Infection Management (SLIM) randomised controlled open-label trial.ERJ Open Res2023; 9: 00635-2022.Porcel JM,et al. Twovs. three weeks of treatment with amoxicillin–clavulanate for stabilized community-acquired complicated parapneumonic effusions. A preliminary non-inferiority, double-blind, randomized, controlled trial.Pleura Peritoneum2020; 5: 20190027.Fitzgerald DB,et al. Steroid Therapy and Outcome of Parapneumonic Pleural Effusions (STOPPE): a pilot randomized clinical trial.Am J Respir Crit Care Med2022; 205: 1093–1101.