bluuebunny/crossref_metadata_2025_split huggingface dataset:
CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease
Authors: Zhao Jingwei , An Ke , Mao Zhijuan , Qu Yi , Wang Danlei , Li Jiangting , Min Zhe , Xue Zheng 
Published: November 2023

BackgroundParkinson’s disease (PD), which is associated to autoimmune disorders, is characterized by the pathological deposition of alpha-synuclein (α-Syn) and loss of dopaminergic (DA) neurons. Th17 cells are thought to be responsible for the direct loss of DA neurons. C-C chemokine ligand 5 (CCL5) specifically induces Th17 cell infiltration into the SN. However, the specific effect of CCL5 on Th17 cells in PD and the relationship between CCL5 and lymphocyte function-associated antigen-1 (LFA-1) expression in Th17 cells are unknown.MethodsWe evaluated the effects of CCL5 on LFA-1 expression in Th17 cells in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and examined Th17 cell differentiation upon CCL5 stimulation in vitro. Furthermore, we assessed the effects of CCL5 on tyrosine kinase zeta-chain-associated protein kinase 70 (ZAP70) and lymphocyte-specific protein tyrosine kinase (LCK) activity in CCL5-stimulated Th17 cells in vivo and in vitro.ResultsCCL5 increased the proportion of peripheral Th17 cells in MPTP-treated mice, LFA-1 expression on Th17 cells, and Th17 cell levels in the SN of MPTP-treated mice. CCL5 promoted Th17 cell differentiation and LFA-1 expression in naive T cells in vitro. Moreover, CCL5 increased Th17 cell differentiation and LFA-1 expression by stimulating LCK and ZAP70 activation in naive CD4+ T cells. Inhibiting LCK and ZAP70 activation reduced the proportion of peripheral Th17 cells and LFA-1 surface expression in MPTP-treated mice, and Th17 cell levels in the SN also significantly decreased.ConclusionCCL5, which increased Th17 cell differentiation and LFA-1 protein expression by activating LCK and ZAP70, could increase the Th17 cell number in the SN, induce DA neuron death and aggravate PD.
Adverse reactions following COVID-19 vaccine among healthcare professionals working in Ethiopia: a facility-based cross-sectional study
Authors: Asefa Adisu , Derjachew Nitsuh , Belete Abebe Muche , Talargia Feredegn , Melese Daniel Molla , Getachew Bekalu 
Published: November 2023

Background of the studyOne of the best medical approaches for halting the spread of infectious diseases is vaccination. During the COVID-19 pandemic, healthcare workers (HCWs) were a high-risk population. Due to their susceptibility in terms of their working environment, front-line healthcare personnel should receive vaccinations before others.ObjectiveThe purpose of this study was to assess the adverse reactions to COVID-19 vaccines among Ethiopian healthcare professionals in 2022.MethodsA facility-based cross-sectional study design was conducted in Addis Ababa Health Facilities, Ethiopia. A total of 290 health professionals who were vaccinated during the study period were involved. Data entry was done by Epidata (version 3.1) and analyzed using SPSS software version 26. Bivariable analysis was conducted and a p value of less than 0.25 was selected for further multivariable analysis. A p value of 0.05 was considered statistically significant at a 95% confidence level.ResultsA total of 277 study participants were successfully involved in the study, yielding a response rate of 95.5%. The study participants comprised 123 (44.4%) women and 154 (55.6%) men. The majority of them (202, 72.9%) had received the Oxford AstraZeneca vaccine. Among the 277 study participants, 142 (51.3%) had developed adverse reactions associated with vaccination. Of these, 81 (29.2%) had moderate adverse reactions. Only 2 (0.7%) had developed adverse reactions that led to hospitalization. The most reported short-term adverse reactions were injection site pain (151, 54.5%), headache (114, 41.2%), fever (104, 37.5%), fatigability and tiredness (94, 33.9%), chills (92, 33.2%), muscle pain (79, 28.5%), and decreased sleep quality (34, 12.3%). The multivariable logistic regression showed that the odds of having an adverse reaction were 1.501 times higher among women than men (AOR = 1.501, 95% CI [1.08, 2.754]).Conclusion and recommendationsThis study revealed that adverse effects following the COVID-19 vaccine were moderate in magnitude and minimal in severity. This study showed that adverse reactions that led to hospitalization were rare. Based on the findings of this study, it is recommended that national, multicenter, prospective, and randomized studies be conducted to assess the independent association of each vaccine.
Impact of China’s National Centralized Drug Procurement Policy on pharmaceutical enterprises’ financial performance: a quasi-natural experimental study
Authors: Sun Zhixuan , Na Xin , Chu Shuzhen 
Published: November 2023

IntroductionIn China, the interest relationship between pharmaceutical enterprises and medical institutions has harmed the healthy development of pharmaceutical enterprises. In November 2018, the National Centralized Drug Procurement (NCDP) policy was published. The NCDP policy severs the interest relationship and significantly impacts on pharmaceutical enterprises’s financial performance.MethodsUsing the implementation of China’s National Centralized Drug Procurement (NCDP) policy as a quasi-natural experiment, this study evaluated the impact of participation in the NCDP policy on pharmaceutical enterprises’ financial performance. We developed a difference-in-difference model to estimate the change in financial performance after NCDP implementation, based on financial data on Chinese listed pharmaceutical enterprises.ResultsWe found that the bid-winning enterprises’ financial performance significantly improved after participating in NCDP. This may be related to lower costs, market share expansion, and increased research and development investment by the bid-winning enterprises.DiscussionTo further promote the high-quality development of pharmaceutical enterprises in China, the government should expand the variety of drugs on the NCDP list (NCDP drugs), while improving the drug patent protection system and the policies to support the bid-winning enterprises.
Comprehensive dialectical behavior therapy for adolescents in a juvenile correctional treatment center: a pilot evaluation
Authors: Folk Johanna B. , Yang Phillip , Thomas Anne , Lyon Jayme , Patel Jaisal , Yoon Clara , Robles-Ramamurthy Barbara 
Published: November 2023

BackgroundIncarcerated youth commonly present with emotion dysregulation, aggression, and comorbid psychiatric disorders, yet often do not receive necessary mental health treatment while confined. It is therefore crucial to expand the evidence base regarding empirically supported mental health interventions which are feasible to implement in secure settings to address incarcerated youth's mental health needs. Through a community-academic partnership, the current pilot study evaluated a comprehensive dialectical behavior therapy program implemented in a juvenile correctional treatment center.MethodsYouth participants (N = 113) were on average 15.37 years old (SD = 1.10, range = 13–17), 68.1% boys, and identified as 69.0% Latinx, 22.1% Black, 8.0% White, and 0.9% Native American. Youth received comprehensive dialectical behavior therapy for adolescents (DBT-A), including individual therapy, skills training groups, family therapy, multi-family skills training groups, and skills coaching in the milieu by direct care staff who participated in extensive training and ongoing consultation team meetings. As part of a facility-designed program evaluation, youth completed a battery of empirically validated assessments of mental health and emotion regulation prior to and following completion of the program.ResultsResults show that comprehensive DBT-A is feasible to implement in a juvenile correctional treatment center and overall, youth improved from pre- to post-treatment in mental health symptoms and emotion regulation, with small to medium effect sizes.ConclusionThese findings build upon a growing literature showing dialectical behavior therapy is a promising intervention for treating emotion dysregulation and mental health conditions and can be successfully implemented in juvenile forensic settings.
Implementation of In-Band Full-Duplex Using Software Defined Radio with Adaptive Filter-Based Self-Interference Cancellation
Authors: Liao Wei-Shun , Zhao Ou , Li Keren , Kawasaki Hikaru , Matsumura Takeshi 
Published: November 2023

For next generation wireless communication systems, high throughput, low latency, and large user accommodation are popular and important required characteristics. To achieve these requirements for next generation wireless communication systems, an in-band full-duplex (IBFD) communication system is one of the possible candidate technologies. However, to realize IBFD systems, there is an essential problem that there exists a large self-interference (SI) due to the simultaneous signal transmission and reception in the IBFD systems. Therefore, to implement the IBFD system, it is necessary to realize a series of effective SI cancellation processes. In this study, we implemented a prototype of SI cancellation processes with our designed antenna, analog circuit, and digital cancellation function using an adaptive filter. For system implementation, we introduce software-defined radio (SDR) devices in this study. By using SDR devices, which can be customized by users, the evaluations of complicated wireless access systems like IBFD can be realized easily. Besides the validation stage of system practicality, the system development can be more effective by using SDR devices. Therefore, we utilize SDR devices to implement the proposed IBFD system and conduct experiments to evaluate its performance. The results show that the SI cancellation effect can reach nearly 100 dB with 10−3 order bit error rate (BER) after signal demodulation. From the experiment results, it can be seen obviously that the implemented prototype can effectively cancel the large amount of SI and obtain satisfied digital demodulation results, which validates the effectiveness of the developed system.
Astrochemical Modeling of Propargyl Radical Chemistry in TMC-1
Authors: Byrne Alex N. , Xue Ci , Cooke Ilsa R. , McCarthy Michael C. , McGuire Brett A. 
Published: November 2023

Abstract
Recent detections of aromatic species in dark molecular clouds suggest that formation pathways may be efficient at very low temperatures and pressures, yet current astrochemical models are unable to account for their derived abundances, which can often deviate from model predictions by several orders of magnitude. The propargyl radical, a highly abundant species in the dark molecular cloud TMC-1, is an important aromatic precursor in combustion flames and possibly interstellar environments. We performed astrochemical modeling of TMC-1 using the three-phase gas-grain code NAUTILUS and an updated chemical network, focused on refining the chemistry of the propargyl radical and related species. The abundance of the propargyl radical has been increased by half an order of magnitude compared to the previous GOTHAM network. This brings it closer in line with observations, but it remains underestimated by 2 orders of magnitude compared to its observed value. Predicted abundances for the chemically related C4H3N isomers within an order of magnitude of observed values corroborate the high efficiency of CN addition to closed-shell hydrocarbons under dark molecular cloud conditions. The results of our modeling provide insight into the chemical processes of the propargyl radical in dark molecular clouds and highlight the importance of resonance-stabilized radicals in polycyclic aromatic hydrocarbon formation.
YunMa: Enabling Spectral Retrievals of Exoplanetary Clouds
Authors: Ma Sushuang , Ito Yuichi , Al-Refaie Ahmed Faris , Changeat Quentin , Edwards Billy , Tinetti Giovanna 
Published: November 2023

Abstract
In this paper, we present YunMa, an exoplanet cloud simulation and retrieval package, which enables the study of cloud microphysics and radiative properties in exoplanetary atmospheres. YunMa simulates the vertical distribution and sizes of cloud particles and their corresponding scattering signature in transit spectra. We validated YunMa against results from the literature. When coupled to the TauREx 3 platform, an open Bayesian framework for spectral retrievals, YunMa enables the retrieval of the cloud properties and parameters from transit spectra of exoplanets. The sedimentation efficiency (f
sed), which controls the cloud microphysics, is set as a free parameter in retrievals. We assess the retrieval performances of YunMa through 28 instances of a K2-18 b-like atmosphere with different fractions of H2/He and N2, and assuming water clouds. Our results show a substantial improvement in retrieval performances when using YunMa instead of a simple opaque cloud model and highlight the need to include cloud radiative transfer and microphysics to interpret the next-generation data for exoplanet atmospheres. This work also inspires instrumental development for future flagships by demonstrating retrieval performances with different data quality.
Les marchés de la téléphonie mobile en Afrique de l’Ouest : dynamiques populaires et stratégies des firmes globales
Authors: Dembélé Abdul-Aziz 
Published: November 2023

Cet article étudie le commerce des produits électroniques grand public, principalement les téléphones mobiles et leurs divers accessoires, sur un lieu marchand : le marché Tecno dans l’agglomération abidjanaise (Côte d’Ivoire). Alors que ces types de commerces sont généralement appréhendés selon une approche de la mondialisation par le bas, le cadre analytique que nous proposons les envisage dans la perspective d’une co-construction : c’est-à-dire à la fois comme produits des capacités d’initiatives des acteurs populaires mais aussi comme des manifestations locales de stratégies déployées par les firmes globales de la téléphonie qui ont compris l’intérêt qu’elles ont à investir et exploiter ces espaces où s’approvisionne la majeure partie de la population urbaine. L’intervention directe et pour le moins originale d’une firme globale – Samsung – sur le marché Tecno est ainsi analysée à la lumière de son articulation aux logiques plurielles d’acteurs populaires. Cet article montre ainsi une convergence d’intérêt entre acteurs globaux et acteurs populaires autour d’un objectif commun : vendre au plus grand nombre.
Brief communication: Alternation of thaw zones and deep permafrost in the cold climate conditions of the East Siberian Mountains, Suntar-Khayata Range
Authors: Sysolyatin Robert , Serikov Sergei , Kirillin Anatoly , Litovko Andrey , Sivtsev Maxim 
Published: November 2023

Abstract. The Suntar-Khayata Range includes numerous natural phenomena interacting with or depending on permafrost conditions. Here, we examine some patterns of deep permafrost and talik zones on adjacent sites. A 210 m deep borehole in siltstone bedrock was equipped for the temperature monitoring of the topmost 15 m and measurements of a deep permafrost temperature profile in July 2010. The temperature curvature in the upper part has a bend, which is consistent with the upper portion justified by climate warming, and shows a steady-state linear geothermal profile below 85 m depth with a high geothermal heat flux. A shallow borehole situated at the river floodplain was used to investigate the thaw zone's temperature regime. The temperatures down to 6.7 m deep have been monitored at 5 min intervals during heavy rainfall, and the temperature readings have behaved quite peculiarly. The thickness of the seasonal freezing layer reaches 5.7 m; moreover the ground temperature increases to 6 ∘C at 6.7 m depth by groundwater heat transfer. This study provides some new insights into the permafrost condition at one of the coldest places in the Northern Hemisphere.
Archidiecezja poznańska (szkic historyczny)
Authors: Komisja Historyczna Archidiecezji Poznańskiej  
Published: November 2023

Celem niniejszego szkicu jest przedstawienie historii diecezji poznańskiej i jej organizacji przez wieki. Diecezja poznańska miała początkowo bardzo rozległe terytorium, obejmując całą ówczesną Polskę. Wraz z powstaniem metropolii gnieźnieńskiej i biskupstw w innych miastach, jej obszar został zawężony. Wprowadzenie nowych diecezji i utrata terytoriów wskutek rozbicia dzielnicowego spowodowały zmiany w jej obszarze. Artykuł ukazuje bogatą historię religijną i kulturową diecezji poznańskiej, począwszy od czasów chrztu Polski, aż po okres okupacji i odbudowę po wojnie. Warto podkreślić, że rozwinięcie kultu Najświętszej Maryi Panny, kultu świętych oraz różnych stowarzyszeń kapłańskich i bractw stanowiło istotny element życia religijnego w diecezji poznańskiej. Trudne czasy okupacji nie zdołały wygasić wiary i oddania duchowieństwa i wiernych. Diecezja poznańska przez minione wieki odgrywała ważną rolę w historii Kościoła w Polsce, a jej historia jest fascynującym przykładem, jak religia i duchowość kształtują życie społeczne i kulturalne regionu.
Hoop structure for horses during winter season: controlling the low critical temperature
Authors: Hutu Ioan , Lungu Bianca , Otava Gabriel , Torda Iuliu , Marc Simona , Boldura Oana , Mircu Calin 
Published: November 2023

Hoop barns, the low input housing structures, can be used in housing horses during fall and winter seasons. One of the hoop structures issue is the level of temperature, which is close to environmental temperature. The aim of this study is to show some technological measures which can overcome the weaknesses of hoop structures such as: feeding strategy, water system and body warming of horses using IR film. The control variable was the skin temperature of six horses, repeatedly measured with FLIR® thermo camera during several levels of environmental temperature. In the study, by using IR heating film at outside temperatures such as 0, -5 and -10°C, the body temperature measured in three body regions (neck, shoulder point and internal angle of eyes) did not differed significant (F=0.167 at p =0.847): without IR heating system, differences were observed (F= 8.905 at p =0.000). Moreover, in low BCS’s animals, below -10°C environmental temperature, in absence of IR heating and if less fiber was present in the diet, low critical temperature signs were observed. In conclusion the hoop structure can be used successfully in horses even when outside temperatures are below low critical temperature of horses if certain conditions are assigned such as: water at 10-15°C, additional hay for fiber, with or without infrared heating.
Study Study on aggression in dogs in a public shelter
Authors: Marza Sorin , KASA Orsolya , TĂTARU Mariana , LĂCĂTUŞ Radu , LUCACI Felix Daniel , PAPUC Ionel 
Published: November 2023

Assessing the behavior of a dog in a shelter is extremely important because the type of behavior can tell us if the animal can be given up for adoption, to whom it can be given up for adoption, if it cannot be given up for adoption and in which direction improvements in behavior need to be made to get it safely given up for adoption. This study aimed to assess the behavior of dogs in a public dog shelter by how a dog behaves towards a person (examiner) in a sequence of situations and to determine the number of individuals who responded with aggression. The behavior test was developed by The Rottweiler Rescue Society (Ontario, Canada) and John Rogerson, Blue Cross, Britain. Following minor modifications, has been used to examine dogs in public shelters. The test contains two additional assessment items from the article "An Evaluation of a Behavior Assessment to Determine the Suitability of Shelter Dogs for Rehoming" [1]. A total of 187 adult dogs were examined, of which 24 were identified with aggressive behavior and the types of aggression identified were dominance, interspecific, or territorial aggression. No behavioral test can show specifically how a dog will behave in a new environment, but the information obtained from the examination can indicate extreme manifestations of canine behavior, such as dominance aggression, possessive aggression, territorial aggression, and separation anxiety.
Walking Together Under Heaven: Traversing between Reformed Catholicity, Synodality, and Tianxia Philosophy
Authors: Kuo Henry S. 
Published: November 2023

Abstract
Synodality is an exciting and new initiative for certain churches but catholicity, being a site of theological contestation, makes synodality a double-edged sword. For one, it empowers the People of God to be subjects, yet, because all God’s people in the church can hold deeply personal perspectives on matters of faith and practice, synodality could simply bare the divisions that already exist between various individuals and groups in the church. As a way forward, this article argues that for synodality to become transformational, two virtues are necessary. The article resources the Chinese concept of tianxia to venture that the two synodal virtues are ecclesiological humility and reciprocal nondomination. The article closes with a reflection on Pope Francis’s encyclical Fratelli Tutti as a theological demonstration of synodal virtues functioning in church and society.
Pengaruh Keputusan Pendanaan, Leverage, Growth Opportunity Terhadap Nilai Perusahaan Dengan Profitabilitas Sebagai Variabel Moderasi
Authors: Sudarmanto Eko , Putri Rumanintya Lisaria , Putri Inez Novitasari 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh keputusan pendanaan, Leverage, Growth Opportunity terhadap nilai perusahaan dengan profitabilitas sebagai variabel moderasi pada perusahaan sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia (BEI). Periode waktu penelitian yang digunakan adalah 4 tahun yaitu tahun 2017-2020. Populasi penelitian ini meliputi seluruh perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2017-2020. Penelitian ini merupakan penelitian asosiatif kausal dengan menggunakan pendekatan kuantitatif. Teknik pengambilan sampel menggunakan teknik purposive sampling. Berdasarkan kriteria yang telah ditetapkan diperoleh 15 perusahaan. Jenis data yang digunakan adalah data sekunder yang diperoleh dari situs Bursa Efek Indonesia. Metode analisis yang digunakan adalah analisis regresi data panel. Hasil penelitian menunjukkan bahwa Keputusan Pendanaan, Leverage, Growth Opportunity secara bersama-sama berpengaruh terhadap Nilai Perusahaan. Keputusan Pendanaan dan Leverage tidak berpengaruh terhadap Nilai Perusahaan. Sedangkan Growth Opportunity berpengaruh terhadap Nilai Perusahaan. Dan Profitabilitas tidak memoderasi Keputusan Pendanaan, Leverage dan Growth Opportunity terhadap Nilai Perusahaan.
Pengaruh komite audit, likuiditas, leverage , dan aktivitas terhadap financial distress
Authors: Swastika Desi , Suriyanti Linda Hetri , Fitriana Nur 
Published: November 2023

The purpose of the study was to analyze the effect of the audit committee, liquidity, leverage, and activity on financial distress. This research is a case study on insurance sector sub-financial service companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2022 period. This study took secondary data from the financial statements of insurance companies. Technical analysis of data Using Audit Committee analysis, liquidity, leverage, and activity. The analysis concluded that the Audit Committee, liquidity, and leverage had no influence on financial distress. Meanwhile, activities can affect financial ditress in insurance companies. Analysis This study uses 4 independent variables, namely the audit committee, liquidity, leverage, and activity where it can be seen that the Adjusted R Squared value is low at 32.8% so that there are still 67.2% of other variables that are not included in this study.

Keywords — financial distress, liquidity, leverage, and activity.