bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated care system leadership: a rapid realist review
Authors: Knight Lisa , Neiva Ganga Rafaela , Tucker Matthew 
Published: February 2024

Purpose
Given the complex nature of integrated care systems (ICSs), the geographical spread and the large number of organisations involved in partnership delivery, the importance of leadership cannot be overstated. This paper aims to present novel findings from a rapid realist review of ICS leadership in England. The overall review question was: how does leadership in ICSs work, for whom and in what circumstances?

Design/methodology/approach
Development of initial programme theories and associated context–mechanism–outcome configurations (CMOCs) were supported by the theory-gleaning activities of a review of ICS strategies and guidance documents, a scoping review of the literature and interviews with key informants. A refined programme theory was then developed by testing these CMOCs against empirical data published in academic literature. Following screening and testing, six CMOCs were extracted from 18 documents. The study design, conduct and reporting were informed by the Realist And Metanarrative Evidence Syntheses: Evolving Standards (RAMESES) training materials (Wong et al., 2013).

Findings
The review informed four programme theories explaining that leadership in ICSs works when ICS leaders hold themselves and others to account for improving population health, a sense of purpose is fostered through a clear vision, partners across the system are engaged in problem ownership and relationships are built at all levels of the system.

Research limitations/implications
Despite being a rigorous and comprehensive investigation, stakeholder input was limited to one ICS, potentially restricting insights from varied geographical contexts. In addition, the recent establishment of ICSs meant limited literature availability, with few empirical studies conducted. Although this emphasises the importance and originality of the research, this scarcity posed challenges in extracting and applying certain programme theory elements, particularly context.

Originality/value
This review will be of relevance to academics and health-care leaders within ICSs in England, offering critical insights into ICS leadership, integrating diverse evidence to develop new evidence-based recommendations, filling a gap in the current literature and informing leadership practice and health-care systems.
Not your average candidate: overqualified job applicants in the eyes of hiring practitioners
Authors: Rafiei Mohsen , Van Dijk Hans 
Published: February 2024

PurposeEarly research on overqualification suggested that overqualification is primarily associated with negative attitudes and behavior. As a consequence, hiring practitioners were advised against hiring overqualified job applicants. However, recent studies have revealed that there are several potential positive consequences of overqualification. Given this change in perspective on overqualification, we examine how hiring practitioners nowadays look at overqualified job applicants, and what their considerations are for hiring an overqualified job applicant or not.Design/methodology/approachWe have interviewed 33 hiring practitioners to examine their attitudes and considerations toward hiring overqualified job applicants.FindingsResults show that hiring practitioners are aware of potential positive as well as negative consequences of overqualification and consider a variety of factors to assess how beneficial hiring an overqualified candidate will be. These factors fall under three categories: Individual considerations, interpersonal considerations and contextual considerations.Originality/valueWe show that overqualification is not a stigma anymore and that the decision to hire an overqualified job applicant or not depends on a mixture of factors that are carefully considered. Two of these three considerations transcend the individual level (i.e. the overqualified person), whereas most research and theories on the consequences of overqualification do not go beyond the individual level. As such, our findings call for more theory and research on interpersonal and contextual factors shaping the consequences of overqualification.
A comprehensive review on mango allergy: Clinical relevance, causative allergens, cross‐reactivity, influence of processing techniques, and management strategies
Authors: Zhao Jinlong , Camus‐Ela Mukeshimana , Zhang Lili , Wang Yuxin , Rennie Gardiner Henric , Wang Jin , Raghavan Vijaya 
Published: February 2024

AbstractMangoes (Mangifera indica) are widely prized for their abundant nutritional content and variety of beneficial bioactive compounds and are popularly utilized in various foods, pharmaceuticals, and cosmetics industries. However, it is important to note that certain proteins present in mango can trigger various allergic reactions, ranging from mild oral allergy syndrome to severe life‐threatening anaphylaxis. The immunoglobulin E‐mediated hypersensitivity of mango is mainly associated with three major allergenic proteins: Man i 1 (class IV chitinase), Man i 2 (pathogenesis‐related‐10 protein; Bet v 1‐related protein), and Man i 4 (profilin). Food processing techniques can significantly affect the structure of mango allergens, reducing their potential to cause allergies. However, it is worth mentioning that complete elimination of mango allergen immunoreactivity has not been achieved. The protection of individuals sensitized to mango should be carefully managed through an avoidance diet, immediate medical care, and long‐term oral immunotherapy. This review covers various aspects related to mango allergy, including prevalence, pathogenesis, symptoms, and diagnosis. Furthermore, the characterization of mango allergens and their potential cross‐reactivity with other fruits, vegetables, plant pollen, and seeds were discussed. The review also highlights the effects of food processing on mango and emphasizes the available strategies for managing mango allergy.
Template‐specific optimization of NGS genotyping pipelines reveals allele‐specific variation in MHC gene expression
Authors: Efstratiou Artemis , Gaigher Arnaud , Künzel Sven , Teles Ana , Lenz Tobias L. 
Published: February 2024

AbstractUsing high‐throughput sequencing for precise genotyping of multi‐locus gene families, such as the major histocompatibility complex (MHC), remains challenging, due to the complexity of the data and difficulties in distinguishing genuine from erroneous variants. Several dedicated genotyping pipelines for data from high‐throughput sequencing, such as next‐generation sequencing (NGS), have been developed to tackle the ensuing risk of artificially inflated diversity. Here, we thoroughly assess three such multi‐locus genotyping pipelines for NGS data, the DOC method, AmpliSAS and ACACIA, using MHC class IIβ data sets of three‐spined stickleback gDNA, cDNA and “artificial” plasmid samples with known allelic diversity. We show that genotyping of gDNA and plasmid samples at optimal pipeline parameters was highly accurate and reproducible across methods. However, for cDNA data, the gDNA‐optimal parameter configuration yielded decreased overall genotyping precision and consistency between pipelines. Further adjustments of key clustering parameters were required tο account for higher error rates and larger variation in sequencing depth per allele, highlighting the importance of template‐specific pipeline optimization for reliable genotyping of multi‐locus gene families. Through accurate paired gDNA‐cDNA typing and MHC‐II haplotype inference, we show that MHC‐II allele‐specific expression levels correlate negatively with allele number across haplotypes. Lastly, sibship‐assisted cDNA‐typing of MHC‐I revealed novel variants linked in haplotype blocks, and a higher‐than‐previously‐reported individual MHC‐I allelic diversity. In conclusion, we provide novel genotyping protocols for the three‐spined stickleback MHC‐I and ‐II genes, and evaluate the performance of popular NGS‐genotyping pipelines. We also show that fine‐tuned genotyping of paired gDNA‐cDNA samples facilitates amplification bias‐corrected MHC allele expression analysis.
Bony proliferations in rheumatoid arthritis, psoriatic arthritis and osteoarthritis using high‐resolution peripheral quantitative computed tomography—A systematic literature review
Authors: Moen Haakon Vilstrup , Hänel Mathias , Therkildsen Josephine , Klose‐Jensen Rasmus , Keller Kresten Krarup , Hauge Ellen Margrethe 
Published: February 2024

AbstractPurposeOsteoarthritis (OA), rheumatoid arthritis (RA), and psoriatic arthritis (PsA) can all lead to the formation of bony proliferations (BP). This systematic review aimed to examine the characteristics of BPs in patients with RA, PsA, OA, and healthy controls (HC) using high‐resolution peripheral quantitative computed tomography (HR‐pQCT). Secondarily, we examined any treatment‐related effect on BP number and size.MethodsA systematic literature search was conducted in PubMed and Embase, and a total of 15 studies were included.ResultsSeven studies demonstrated a disease‐specific variation in BP location. One study showed no difference in the number of BPs between patients with PsA and OA. The number of BPs was greater in patients with PsA compared to RA in one study, and to HC in another study, while one study documented no difference in the number of BPs between patients with RA and HC. Five studies showed larger BPs in patients with PsA compared to HC, and one study larger BPs in patients with PsA compared to RA. One study showed no difference in BP size between patients with PsA and OA. Secukinumab may have a potential effect on arresting BP progression. Otherwise, no other treatment was reported to influence BP size and progression. No standard definitions or measurement techniques for BPs using HR‐pQCT have been identified.ConclusionBPs showed disease‐specific variations in location, size, and number. Results regarding treatment‐related effects are sparse. An agreement on the definition and measurement technique for BPs using HR‐pQCT is warranted for diagnostic accuracy, disease comparability, and monitoring potential.
A unified framework for time‐to‐detection occupancy and abundance models
Authors: Priyadarshani Dinusha , Huynh Huu‐Dinh , Altwegg Res , Hwang Wen‐Han 
Published: February 2024

Abstract

Time‐to‐detection (TTD) occupancy models are increasingly used to study site occupancy of organisms. Occupancy is a reduced representation of abundance (distinguishing only between and individuals), which is also often a quantity of interest. In this paper, we present a novel framework for TTD occupancy models that address limitations of existing approaches. Our approach incorporates factors that accommodate detection heterogeneity among sites/visits and inter‐visit dependency, allowing for the relaxation of some restrictive assumptions inherent in previous models. As a result, our framework offers a robust and versatile tool for analysing various ecological data sets.

We employ a maximum likelihood approach to estimate model parameters and conduct inference for the proposed TTD occupancy models. A key feature of these models is the introduction of a community parameter. This parameter characterizes the similarity of detectabilities, ranging from complete independence to complete identity, across multiple site visits. This framework disentangles the detection rate, abundance and occupancy, similar to the popular N‐mixture model. For situations where abundance estimation is not the primary goal, a family of mixed gamma exponential TTD models is developed, which generally exhibit more stable numerical properties compared to N‐mixture type TTD models.

The performance of the proposed models and some reduced models is evaluated through simulation studies. The results indicate that the N‐mixture TTD model tends to considerably overestimate the occupancy probability when the community parameter is less than one, a condition necessary to satisfy the strict closure population assumption. On the other hand, the standard exponential TTD occupancy model underestimates the occupancy probability in the presence of unobserved detection heterogeneity and inter‐visit dependency. An analysis of bird species in the Karoo region of South Africa demonstrates the enhanced flexibility of the proposed TTD occupancy models for data fitting.

This paper demonstrates the importance of employing more flexible and general models to accurately capture the complexities of ecological systems or survey data. We provide R‐code to fit all considered models to data. The proposed TTD model framework contributes to enhancing our understanding of species occupancy distributions.
The natural history of lifetime psychiatric disorders in patients with obsessive‐compulsive disorder followed over half a century
Authors: Klenfeldt Isak Fredén , Skoog Gunnar , Skoog Johan , Skoog Ingmar 
Published: February 2024

AbstractObjectiveFew long‐term studies have examined the life‐time prevalence of comorbid psychiatric conditions in patients with obsessive‐compulsive disorder (OCD). We therefore studied the frequency of comorbid psychiatric disorders, and their relation to onset and prognosis, in patients with OCD who were followed for almost half a century.MethodsDuring 1947–1953, 285 OCD patients were admitted as inpatients to a university hospital in Gothenburg, Sweden. Among those, 251 (88%) accepted a structured comprehensive psychiatric examination in 1954–1956. In 1989–1993, 176 survivors were eligible and 144 (response rate 82%) were re‐examined. The same psychiatrist performed both examinations. OCD was diagnosed according to the Schneider criteria, and other mental disorders according to DSM‐IV. Mean follow‐up since onset was 47 years.ResultsThe lifetime frequency of depressive disorders was 84.7% (major depression 43.8%), generalized anxiety disorder (GAD) 71.5%, panic anxiety disorder 47.9%, agoraphobia 52.1%, specific phobias 64.6%, social phobia 47.9%, paranoid conditions 40.3% (29.1% paranoid ideation), psychotic disorders 15.3%, alcohol abuse 13.2% (men 39%, women 3%) and substance abuse 17.4%. Specific phobia most often started before OCD, while depression had a varied onset in relation to OCD. Social phobia, agoraphobia, GAD, alcohol and substance abuse, psychotic disorders and paranoid conditions most often started after OCD. Presence of GAD, psychotic disorder and substance abuse worsened prognosis of OCD.ConclusionComorbid psychiatric conditions are common in OCD patients, and have onset throughout the course. OCD signals vulnerability for other psychiatric conditions, which are important to detect in clinical practice as they negatively affect the outcome.
Intra‐specific variation and climate differentially shape the thermal germination niches of three co‐occurring woodland forbs
Authors: Price Meridy , Harrison Peter A. , Jordan Rebecca , Steane Dorothy , Vaillancourt René E. , Prober Suzanne M. 
Published: February 2024

AbstractUnderstanding plant responses to temperature is critical for predicting their vulnerability to global warming and for planning management responses. Germination is a key life‐stage, strongly regulated by temperature, that affects the potential for plant populations to persist. Here, we compared the thermal germination niches of three unrelated, declining woodland forb species – Arthropodium fimbriatum (Asparagaceae), Bulbine bulbosa (Asphodelaceae), Microseris walteri (Asteraceae) – across common temperature and precipitation gradients, to characterize the relationships with home‐site climate, and associated implications for ecological restoration in a changing climate. Open‐pollinated seed were sampled from 14–15 populations per species across an aridity gradient in south‐eastern Australia. Germination responses for each population were tested in controlled temperature cabinets under five temperature regimes encompassing contemporary and projected future temperatures. Optimum germination temperature and thermal germination niche were characterized and assessed for associations with home‐site climate and potential germination under projected climate change. The three species showed significant intra‐specific variation in the thermal germination niche. Optimum germination temperature was correlated with home‐site climate, suggesting adaptive variation among populations in germination requirements. However, the pattern of variation in optimum germination across the environmental gradients was not always consistent among the species. Future temperatures projected under climate change tended to be outside the current thermal germination niche for all species, indicating potential benefits of incorporating pre‐adapted populations in ecological restoration. Climate‐related intra‐specific variation in the thermal germination niche provides evidence for local adaptation to climate in all three forb species and suggests potential differences among populations in vulnerability to global warming. These results emphasize the importance of understanding the extent of intra‐specific variation in key life history traits to better manage and conserve populations and restore their ecosystems as climates change.
Prevalence and patterns of comorbidities in older people with type 2 diabetes in Australian primary care settings
Authors: Wong Wei Jin , Nguyen Tu , Fortin Martin , Harrison Christopher 
Published: February 2024

AbstractObjectiveThe aim of this study was to identify the prevalence and patterns of comorbidity in community‐dwelling older people with type 2 diabetes mellitus (T2DM) attending general practice settings in Australia.MethodsThis study involved a cross‐sectional analysis using the Bettering the Evaluation and Care of Health (BEACH) sub‐study data. In a series of sub‐studies, a representative sample of general practitioners was asked to record all diagnosed chronic conditions for patients at 40 consecutive encounters using structured paper‐based recording forms. The dataset was analysed with descriptive analyses, and exploratory factor analyses were applied to examine comorbidity patterns.ResultsOf the 14,042 patients aged 65 years or older, 2688 had a diagnosis of T2DM (19%). Of the 2688 patients with T2DM, hypertension was present in 67% (95% CI: 64.6–70.0), followed by arthritis 52% (95% CI: 48.8–54.8), hyperlipidaemia 45% (95% CI: 41.8–47.9), ischemic heart disease, 23% (95% CI: 20.7–24.9), depression 16% (95% CI: 48.8–54.8), atrial fibrillation 10% (95% CI: 8.9–11.6), congestive heart failure 7% (95% CI: 6.0–8.1), stroke/cerebrovascular accident 7% (95% CI: 5.4–8.2) and peripheral vascular disease 5% (95% CI: 4.4–6.2). We identified two comorbidity patterns among older people with T2DM. The first were psychological and musculoskeletal conditions and the second were cardiovascular conditions and chronic renal failure.ConclusionsThe prevalence of cardiovascular and non‐cardiovascular comorbidities in community‐dwelling older people with T2DM was high. Adequate primary care strategies should be in place to support the long‐term care for this population.
Do good relationships contribute to innovative behaviour? A study of relationship conflict affecting team innovative behaviour
Authors: Chang Po‐Chien , Xu Xun , Gao Xiaoxiao , Lee Amber Yun‐Ping 
Published: February 2024

AbstractThis study examines the relationship between relationship conflict and cross‐functional team innovative behaviour with transactive memory system (TMS) as a mediator and team‐oriented leadership as a moderator. Adopting a two‐wave data collection procedure, 584 team members and 113 team leaders from 20 organizations participated in this study. The PROCESS macro for SPSS was used to test the hypothesized relationships. The results indicate that the TMS mediates the relationship between relationship conflict and cross‐functional team innovative behaviour. Moreover, team‐oriented leadership moderates the relationship between relationship conflict and cross‐functional team innovative behaviour as well as between relationship conflict and the transactive memory system. Additionally, it moderates the indirect effect of relationship conflict and cross‐functional team innovative behaviour via the TMS. In particular, all three relationships become weaker when team‐oriented leadership is high. Based on social information processing theory, this study makes an additional contribution to the current conflict management literature by providing empirical evidence on the mediating role of the TMS and the moderating role of team‐oriented leadership in how relationship conflict affects cross‐functional team innovative behaviour.
Identification of allergens from Aspergillus fumigatus—Potential association with lung damage in asthma
Authors: Rick Eva‐Maria , Woolnough Kerry , Richardson Matthew , Monteiro William , Craner Michelle , Bourne Michelle , Cousins David John , Swoboda Ines , Wardlaw Andrew John , Pashley Catherine Helen 
Published: February 2024

AbstractBackgroundComponent‐resolved diagnosis allows detection of IgE sensitization having the advantage of reproducibility and standardization compared to crude extracts. The main disadvantage of the traditional allergen identification methods, 1‐ or 2‐dimensional western blotting and screening of expression cDNA libraries with patients' IgEs, is that the native structure of the protein is not necessarily maintained.MethodsWe used a novel immunoprecipitation technique in combination with mass spectrometry to identify new allergens of Aspergillus fumigatus. Magnetic Dynabeads coupled with anti‐human IgE antibodies were used to purify human serum IgE and subsequently allergens from A. fumigatus protein extract.ResultsOf the 184 proteins detected by subsequent mass peptide fingerprinting, a subset of 13 were recombinantly expressed and purified. In a panel of 52 A. fumigatus‐sensitized people with asthma, 23 non‐fungal‐sensitized asthmatics and 18 healthy individuals, only the former showed an IgE reaction by immunoblotting and/or ELISA. We discovered 11 proteins not yet described as A. fumigatus allergens, with fructose‐bisphosphate aldolase class II (FBA2) (33%), NAD‐dependent malate dehydrogenase (31%) and Cu/Zn superoxide dismutase (27%) being the most prevalent. With respect to these three allergens, native versus denatured protein assays indicated a better recognition of the native proteins. Seven of 11 allergens fulfilled the WHO/IUIS criteria and were accepted as new A. fumigatus allergens.ConclusionIn conclusion, we introduce a straightforward method of allergen identification from complex allergenic sources such as A. fumigatus by immunoprecipitation combined with mass spectrometry, which has the advantage over traditional methods of identifying allergens by maintaining the structure of the proteins.