bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of simultaneous contact allergies in patients with contact sensitization to oxidised linalool and oxidised limonene
Authors: Sukakul Thanisorn , Bruze Magnus , Mowitz Martin , Bergendorff Ola , Björk Jonas , Dahlin Jakob , Svedman Cecilia 
Published: October 2023

AbstractBackgroundContact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.ObjectivesTo demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.MethodsA retrospective analysis of consecutive dermatitis patients in 2015–2020 was performed.ResultsOf all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p‐value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p‐value <0.001, odds ratio (95% confidence interval) = 4.15 (3.01–5.73)). Patients with simultaneous contact allergies to both linalool and limonene HPs had contact allergies to many other screening and fragrance allergens.ConclusionsSimultaneous positive PT reactions to allergens in baseline series and fragrances are common in patients with the HPs contact allergy, especially linalool HPs. The pattern of simultaneous PT reactions principally suggested the co‐sensitization of the cosmetic allergens.
The Talmud on usury
Authors: Koehler Benedikt 
Published: October 2023

AbstractA ban on usury was endorsed by Judaism, Christianity, and Islam. Usury was banned in the Books of Moses, but defined in the Babylonian Talmud as a ‘reward for waiting’. Conceptions of usury in early Christianity and Islam accorded with that of the Talmud. A misrepresentation of the Talmudic conception of usury by Jacob Neusner was refuted by Emil Cohn.
Resting echocardiographic parameters can exclude significant coronary artery disease: A comparison with coronary computed tomography angiography
Authors: Jinno Shinji , Yamada Akira , Sugimoto Kunihiko , Chan Jonathan , Nakashima Chihiro , Funato Yusuke , Hoshino Naoki , Hoshino Meiko , Takada Kayoko , Sato Yoshihiro , Kawai Hideki , Sarai Masayoshi , Ito Hiroyasu , Izawa Hideo 
Published: October 2023

AbstractIntroductionCoronary computed tomography angiography (CCTA) is known to have a high negative predictive value (NPV) in identifying coronary artery disease (CAD). This study aimed to examine whether resting echocardiographic parameters could exclude significant CAD on CCTA.MethodsWe recruited 142 patients who had undergone both CCTA and echocardiography within a 3‐month window. Based on the CCTA findings, patients were divided into two groups: Group A (non‐significant CAD, defined as all coronary segments having <50% stenosis) and Group B (significant CAD). Resting echocardiographic parameters were compared between the two groups to identify predictors of non‐significant CAD on CCTA.ResultsA total 92 patients (mean age, 68 ± 13 years; males, 62%) were eligible for this study; 50 in Group A and 42 in Group B. Among the various echo parameters, left atrial volume index (LAVI) and left ventricular (LV) global longitudinal strain (GLS) were significantly lower in Group A (23.5 ± 7.6 vs. 33.6 ± 7.4 mL/m2, p < .001; −20.2 ± 1.8% vs. −16.8 ± 2.0%, p < .001, respectively). Analysis of the receiver operating characteristic curve revealed that the cutoff value to exclude significant CAD on CCTA was 29.0 mL/m2 for LAVI (NPV 80.8%) and −18.1% for GLS (NPV 80.7%). The NPV increased to 95.0% when these parameters were combined (LAVI < 29.0 mL/m2 and GLS < −18.1%).ConclusionThe combination of resting LAVI and GLS was clinically useful in excluding significant CAD via CCTA.
6G‐enabled internet of medical things
Authors: Dhanda Sumit Singh , Singh Brahmjit , Jindal Poonam , Sharma Tarun Kumar , Panwar Deepak 
Published: October 2023

AbstractHealthcare is the foremost concern for any country. UN has also fixed ‘good health’ and well‐being’ as its third sustainable development goal. CoVID‐19 era has shown the vulnerability of health infrastructure worldwide. As per WHO, aging population of the world would put enormous pressure on health infrastructure in coming decades. With lack of healthcare professionals and limited budget to achieve UNSDG goal‐3, IoMT with its huge umbrella of medical services and applications can address these issues. 5G has been deployed in many countries and vision for 6G have been finalized by different research groups. 6G will help Internet of Medical Things to realize its full potential. In this work, an open ‘6G enabled IoMT’ architecture has been presented. It can integrate a wide number of services. The limitations of 5G in catering to such a network are also highlighted. The challenges and open issues are presented in the light of services and applications that can be provided by the purposed architecture. A brief overview of 6G is also provided.
CYP1A1 immunohistochemistry is highly specific for angiofibroma of soft tissue among morphological mimics
Authors: Bauer Anna H , Fletcher Christopher D M , Hornick Jason L , Papke David J 
Published: October 2023

AimsAngiofibroma of soft tissue (AFST) is a benign, morphologically distinctive tumour type that harbours recurrent AHRR::NCOA2 fusions in 60–70% of cases and shows a non‐specific immunophenotype, expressing EMA in roughly half of cases. The AHRR::NCOA2 fusion results in increased expression of cytochrome P450 1A1 (CYP1A1); a recent study demonstrated CYP1A1 immunohistochemistry (IHC) to be moderately sensitive and highly specific for AFST.Methods and resultsIn this study, we sought to validate these findings in a larger independent cohort of 30 AFST, as well as 215 morphological mimics, including 30 solitary fibrous tumours, 29 myxoid liposarcomas, 28 low‐to‐intermediate grade myxofibrosarcomas (MFS), 20 atypical spindle cell lipomatous tumours (ASCLT), 20 cellular angiofibromas, 10 cases each of spindle cell lipoma, neurofibroma, malignant peripheral nerve sheath tumour, superficial angiomyxoma, cellular myxoma, soft tissue perineurioma and deep fibrous histiocytoma, and nine cases each of low‐grade fibromyxoid sarcoma and mammary‐type myofibroblastoma. We found CYP1A1 IHC to be 70% sensitive for AFST, with granular cytoplasmic staining in 21 of 30 tumours, and 98% specific, with staining in only five morphological mimics: two deep fibrous histiocytomas, one MFS, one cellular angiofibroma and one ASCLT.ConclusionsThese findings confirm that CYP1A1 is 70% sensitive, consistent with the prevalence of AHRR::NCOA2 fusions that up‐regulate this protein, and that it is highly specific among morphological mimics.
Let‐7a promotes periodontal bone regeneration of bone marrow mesenchymal stem cell aggregates via the Fas/FasL‐autophagy pathway
Authors: Yang Shiyao , Gao Jing , Chen Meng , Sun Yuting , Qiao Xin , Mao Hongchen , Guo Li , Yu Yang , Yang Deqin 
Published: October 2023

AbstractPeriodontal bone regeneration using bone marrow mesenchymal stem cell (BMMSC) transplantation is a promising method; however, the method for osteogenic differentiation of BMMSCs needs to be improved. In this research, we sought to identify the roles of let‐7a in the osteogenesis of BMMSCs and to provide a potential method for periodontal bone regeneration. Our previous study revealed that Fas/FasL is a target of let‐7a. In this study, we demonstrated that let‐7a overexpression significantly enhanced BMMSC‐CAs osteogenesis both in vitro and in vivo. Mechanistically, upregulation of Fas/FasL using the rfas/rfaslg plasmid obstructed the osteogenesis of BMMSCs by inhibiting autophagy. Furthermore, we confirmed that overexpression of let‐7a activated autophagy and alleviated the inhibited osteogenesis by the autophagy inhibitor 3‐MA and the rfas/rfaslg plasmid of BMMSCs. In general, our findings showed that let‐7a promoted the osteogenesis of BMMSCs through the Fas/FasL‐autophagy pathway, suggesting that the application of let‐7a in BMMSC‐CAs based periodontal bone regeneration could be a promising strategy.
A distinctive subgingival microbiome in patients with periodontitis and Alzheimer's disease compared with cognitively unimpaired periodontitis patients
Authors: Na Hee Sam , Jung Na‐Yeon , Song Yuri , Kim Si Yeong , Kim Hyun‐Joo , Lee Ju Youn , Chung Jin 
Published: October 2023

AbstractAimPeriodontitis is caused by dysbiosis of oral microbes and is associated with increased cognitive decline in Alzheimer's disease (AD), and recently, a potential functional link was proposed between oral microbes and AD. We compared the oral microbiomes of patients with or without AD to evaluate the association between oral microbes and AD in periodontitis.Materials and MethodsPeriodontitis patients with AD (n = 15) and cognitively unimpaired periodontitis patients (CU) (n = 14) were recruited for this study. Each patient underwent an oral examination and neuropsychological evaluation. Buccal, supragingival and subgingival plaque samples were collected, and microbiomes were analysed by next‐generation sequencing. Alpha diversity, beta diversity, linear discriminant analysis effect size, analysis of variance‐like differential expression analysis and network analysis were used to compare group oral microbiomes.ResultsAll 29 participants had moderate to severe periodontitis. Group buccal and supragingival samples were indistinguishable, but subgingival samples demonstrated significant alpha and beta diversity differences. Differential analysis showed subgingival samples of the AD group had higher prevalence of Atopobium rimae, Dialister pneumosintes, Olsenella sp. HMT 807, Saccharibacteria (TM7) sp. HMT 348 and several species of Prevotella than the CU group. Furthermore, subgingival microbiome network analysis revealed a distinct, closely connected network in the AD group comprised of various Prevotella spp. and several anaerobic bacteria.ConclusionsA unique microbial composition was discovered in the subgingival region in the AD group. Specifically, potential periodontal pathogens were found to be more prevalent in the subgingival plaque samples of the AD group. These bacteria may possess a potential to worsen periodontitis and other systemic diseases. We recommend that AD patients receive regular, careful dental check‐ups to ensure proper oral hygiene management.
Spatial Dependence via the Internal Capital Markets of U.S. Global Banks
Authors: D'AVINO CARMELA , SHABANI MIMOZA 
Published: October 2023

AbstractIn this paper, we estimate the cross‐border liquidity network created by U.S. global banks via their internal capital markets to capture the spatial dependence or bilateral proximity between branches located in different countries. Results from dynamic spatial panel regressions indicate that the foreign branches in nearby countries show common lending patterns. A 1% increase in lending in branches in proximate locations is associated with an estimated increase of 0.25% in local lending. Further interdependencies are evidenced by the positive liquidity and monetary policy spillovers on local lending, with marginal spatial effects estimated to be around 1.11% and 0.14%, respectively.
Feeding signals inhibit fluid‐satiation signals in the mouse lateral parabrachial nucleus to increase intake of highly palatable, caloric solutions
Authors: Aitken Connor M. , Jaramillo Janine C. M. , Davis Warren , Brennan‐Xie Liam , McDougall Stuart J. , Lawrence Andrew J. , Ryan Philip J. 
Published: October 2023

AbstractChemogenetic activation of oxytocin receptor‐expressing neurons in the parabrachial nucleus (OxtrPBN neurons) acts as a satiation signal for water. In this research, we investigated the effect of activating OxtrPBN neurons on satiation for different types of fluids. Chemogenetic activation of OxtrPBN neurons in male and female transgenic OxtrCre mice robustly suppressed the rapid, initial (15‐min) intake of several solutions after dehydration: water, sucrose, ethanol and saccharin, but only slightly decreased intake of Ensure®, a highly caloric solution (1 kcal/mL; containing 3.72 g protein, 3.27 g fat, 13.42 g carbohydrates, and 1.01 g dietary fibre per 100 mL). OxtrPBN neuron activation also suppressed cumulative, longer‐term (2‐h) intake of lower caloric, less palatable solutions, but not highly caloric, palatable solutions. These results suggest that OxtrPBN neurons predominantly control initial fluid‐satiation responses after rehydration, but not longer‐term intake of highly caloric, palatable solutions. The suppression of fluid intake was not because of anxiogenesis, but because OxtrPBN neuron activation decreased anxiety‐like behaviour. To investigate the role of different PBN subdivisions on the intake of different solutions, we examined FOS as a proxy marker of PBN neuron activation. Different PBN subdivisions were activated by different solutions: the dorsolateral PBN similarly by all fluids; the external lateral PBN by caloric but not non‐caloric solutions; and the central lateral PBN primarily by highly palatable solutions, suggesting PBN subdivisions regulate different aspects of fluid intake. To explore the possible mechanisms underlying the minimal suppression of Ensure® after OxtrPBN neuron activation, we demonstrated in in vitro slice recordings that the feeding‐associated agouti‐related peptide (AgRP) inhibited OxtrPBN neuron firing in a concentration‐related manner, suggesting possible inhibition by feeding‐related neurocircuitry of fluid satiation neurocircuitry. Overall, this research suggests that although palatable beverages like sucrose‐ and ethanol‐containing beverages activate fluid satiation signals encoded by OxtrPBN neurons, these neurons can be inhibited by hunger‐related signals (agouti‐related peptide, AgRP), which may explain why these fluids are often consumed in excess of what is required for fluid satiation.
Failing kidneys: Hotspots, blind spots and biopolitics of indifference
Authors: Kierans Ciara , Padilla‐Altamira César 
Published: October 2023

AbstractChronic kidney disease of non‐traditional cause (CKDnt) is commonly associated with monocropping agriculture, heat stress and impoverished working conditions, referred to as CKDnt “hotspots.” The condition is also emerging in various sites of environmental contamination, raising questions as to whether multiple variants of the condition exist as a result of different ecologies and different human‐environment interactions. This paper examines the emergence of CKDnt around Lake Chapala in Mexico, where we document local efforts to gain recognition and reparation for CKDnt. We follow the ways patients, families and activists have mobilized specific and interlocking infrastructural failures to enact complaint and confront state inaction and neglect of their bodies, communities, and environments. Though their labors have formally achieved little, we discuss how they make visible a biopolitics of indifference, one bound to the production of structural “blindspots.”
Mechanisms Leading to Stabilization and Incomplete Combustion in Lean CH4/H2 Swirling Wall-Impinging Flames
Authors: Fan Luming , Savard Bruno , Fond Benoît , Durocher Antoine , Bergthorson Jeffrey , Carlyle Spencer , Vena Patrizio 
Published: October 2023

Abstract
In gas turbines, confined highly turbulent flames unavoidably propagate in the vicinity of a relatively cool combustor liner, affecting both the local flame structure and global operation of the combustion system. In our recent work, we demonstrated, using simultaneous [OH] × [CH2O] planar laser-induced fluorescence (PLIF) and stereo-particle image velocimetry (stereo-PIV), that lean CH4/H2 flames at a high Karlovitz number can present a highly broken structure near wall, highlighted by a diffuse CH2O cloud, which suggests local quenching and incomplete oxidation. Such high Karlovitz numbers were achieved using an inclined plate, which substantially extended the lean flammability of the low swirl flames. Yet, how a cooled wall acting as a heat sink played a conducive role in stabilizing high Ka flames remains unanswered. In addition, the origin of the CH2O cloud is also unclear. Hence, in this work, we look to better understand the stabilization mechanisms for lean and ultralean flames on the same configuration, and how they may change with a parametric variation of plate incident angle, plate-nozzle distance, and bulk velocity up to the critical values that lead to flame blow off. The results show that the impinging swirling flow creates a low speed region that helps hold the flame, while the wall prevents mixing with ambient cold air. The production of diffuse CH2O, which indicates the occurrence of local quenching, is associated with a mean strain rate K beyond the extinction strain rate (ESR) Ke. For CH4 flames, most of the reaction zones reside within |K|/Ke&lt;1; for 70% H2 flames at ϕ=0.4, the reaction zones are highly broken and scattered in a large area, where |K|/Ke&lt;8, the interspace of which is fully filled by CH2O. In other words, high H2 fraction flames appear to be more robust to persistent strain rate, thus extending their stability envelope. However, these flames can subsist as highly broken flames featuring strong incomplete combustion.
A Literature Review of NOx Emissions in Current and Future State-of-the-Art Gas Turbines
Authors: Dennis Richard , Long Henry A. , Jesionowski Gary 
Published: October 2023

Abstract
Current U.S. government policy seeks to achieve a completely carbon-free economy by 2050, with a carbon-free electricity sector by 2035 (per executive orders #14008 and #14057). To address these goals, the U.S. Department of Energy is evaluating strategies and technologies that support the production, utilization, transport, and storage of hydrogen (via initiatives such as Department of Energy's (DOE) Energy Earthshot—Hydrogen and various DOE funding opportunity announcements). A carbon-free fuel such as hydrogen cannot be overvalued in a dynamic electric energy sector seeking to decarbonize. One of the most important technologies needed to achieve the goal of a carbon-free electricity sector is a 100% hydrogen-fueled gas turbine. Accommodating hydrogen-based fuels has been a key goal for various original engine manufacturers (OEMs) for many years, but much more research and development (R&D) is needed. The purpose of this paper is to highlight the current state-of-the- art of hydrogen turbine technology, especially regarding nitrogen oxide (NOX) emissions compared to natural gas-fueled turbines. NOX is the primary criteria pollutant from thermally driven combustion turbines and should be controlled to levels that are equivalent to or below existing standards (as reported “existing standards” for hydrogen-fueled gas turbines may need to be rebaselined). This paper will provide an overview of hydrogen as a fuel and various NOX emissions control techniques that are relevant for hydrogen-based fuels. A conclusion from this overview is that, with some level of R&D, NOX emissions from hydrogen-fueled gas turbines can be controlled to levels similar to those produced by state-of-the-art (SOTA) natural gas-fueled combustion turbines while remaining competitive in terms of performance and efficiency.
Isolation and characterization of polyhydroxyalkanoate-degrading bacteria in seawater at two different depths from Suruga Bay
Authors: Hachisuka Shin-Ichi , Sakurai Tetsuo , Mizuno Shoji , Kosuge Kazuho , Endo Sayaka , Ishii-Hyakutake Manami , Miyahara Yuki , Yamazaki Motoyuki , Tsuge Takeharu 
Published: October 2023

ABSTRACT

Polyhydroxyalkanoate (PHA) is a biopolymer used as a plastic material. PHA can be a panacea for global plastic pollution as being susceptible to biodegradation in seawater besides soil and freshwater. However, the current knowledge of species that degrade PHA in marine environments is insufficient. This study first demonstrated the biodegradation of PHA in the surface and deep seawater from Suruga Bay (Shizuoka, Japan). We isolated 11 and 80 strains of PHA-degrading bacteria from the seawater and from the seawater after a biochemical oxygen demand test, respectively. Subsequent 16S rRNA analysis suggested that these strains belong to the genus
Alloalcanivorax
,
Alteromonas
,
Arenicella
,
Microbacterium
, or
Pseudoalteromonas. Arenicella
spp. and
Microbacterium
spp. have not been previously identified as marine PHA-degrading bacteria. The selected
Arenicella
sp. showed no growth at 10°C and displayed weak PHA degradation ability. This result is consistent with the fact that the strain was not isolated from the cold deep seawater but only from the surface seawater. We also predicted the domain composition of the extracellular poly(3-hydroxybutyrate) depolymerase in the type strains closest to the isolated strains. Depolymerases in the genus
Microbacterium
showed a different pattern of domain composition from those in previously identified marine bacteria, fitting a terrestrial type. Subsequently, we performed an
in vitro
assay of a depolymerase from
Microbacterium schleiferi
(DSM 20489), isolated from soil and closest to the isolated
Microbacterium
spp. in this study. The depolymerase showed substantial activity in the presence of NaCl, whereas it showed reduced activity without NaCl.

IMPORTANCE

Polyhydroxyalkanoate (PHA) is a highly biodegradable microbial polyester, even in marine environments. In this study, we incorporated an enrichment culture-like approach in the process of isolating marine PHA-degrading bacteria. The resulting 91 isolates were suggested to fall into five genera (
Alloalcanivorax
,
Alteromonas
,
Arenicella
,
Microbacterium
, and
Pseudoalteromonas
) based on 16S rRNA analysis, including two novel genera (
Arenicella
and
Microbacterium
) as marine PHA-degrading bacteria.
Microbacterium schleiferi
(DSM 20489) and
Alteromonas macleodii
(NBRC 102226), the type strains closest to the several isolates, have an extracellular poly(3-hydroxybutyrate) [P(3HB)] depolymerase homolog that does not fit a marine-type domain composition. However,
A. macleodii
exhibited no PHA degradation ability, unlike
M. schleiferi
. This result demonstrates that the isolated
Alteromonas
spp. are different species from
A. macleodii
. P(3HB) depolymerase homologs in the genus
Alteromonas
should be scrutinized in the future, particularly about which ones work as the depolymerase.