bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid on‐site evaluation improves diagnostic performance of fine‐needle aspiration cytology for salivary lesions: Comparison of data from two cancer centers in southern China
Authors: Xu Manbin , Deng Lifei , Peng Kunpeng , Wei Xiaolong , Xie Mei , Liu Muyuan , Peng Hanwei 
Published: January 2024

AbstractObjectivesTo evaluate the diagnostic performance of Milan system for reporting salivary gland cytopathology (MSRSGC) in two southern China tertiary cancer centers and investigate the impact of rapid on‐site evaluation (ROSE) on FNAC performance.Materials and MethodsFive hundred and forty‐nine patients who underwent FNAC for salivary lesions with surgical follow‐up from two centers were enrolled in this retrospective cohort study. All slides were recategorized using MSRSGC after consensus on diagnostic criteria for each category. The diagnostic performance of FNAC for salivary lesions was evaluated and compared and the impact of ROSE on FNAC performance was analyzed.ResultsThe distribution of cases per category based on the MSRSGC criteria in the whole series was as followed: ND 49 (8.9%), NN 76 (14.4%), BN 262 (47.7%), AUS 20 (3.6%), SUMP 43 (7.8%), SM 21 (3.8%), M 78 (14.2%). The SUMC series had significantly more ND distributions than JXCH did (16.2% vs. 0, p = .000). Risk of malignancy for each category in the total series was as followed: 42.9% for ND, 9.2% for NN, 3.8% for BN, 30.0% for AUS, 23.3% for SUMP, 81.0% for SM, and 94.9% for M. When ND and AUS/SUMP were excluded, the sensitivity, specificity, PPV, NPV, and accuracy were 84.0%, 97.1%, 89.9%, 95.1%, and 94.0%, respectively; sensitivity, specificity, PPV, NPV, and accuracy were comparable between the two centers.ConclusionsFNAC using MSRSGC provides a good tool in preoperative evaluation for salivary lesions in southern China. ROSE improves its diagnostic performance by reducing the ratio of the ND category.
The ecological suitability area of Cirsium lineare (Thunb.) Sch.‐Bip. under future climate change in China based on MaxEnt modeling
Authors: Fang Hu‐Qiang , Zhang Peng‐Fei , Xu Shao‐Wei , Xu Teng , He Bing , Wang En , Dong Chang‐Wu , Yang Qing‐Shan 
Published: January 2024

AbstractMany kinds of medicinal ingredients occur in Cirsium lineare that have good clinical efficacy, conferring on this species its high medicinal development value. However, with a rapidly changing global climate, it is increasingly imperative to study the factors affecting the habitat distribution and survival of species. We predicted the current and future distribution areas of suitable habitats for C. lineare, analyzed the importance of environmental variables in influencing habitat shifts, and described the alterations to suitable habitats of C. lineare in different periods (modern, 2050s, and 2070s) and scenarios (RCP2.6, RCP4.5, and RCP8.5). The results show that, under the current climate, the total suitable area of C. lineare is about 2,220,900 km2, of which the highly suitable portion amounts to ca. 292,600 km2. The minimum temperature of the coldest month, annual precipitation, and mean daily temperature range are the chief environmental variables affecting the distribution of habitat for C. lineare. In the same period, with rising greenhouse gas emission concentrations, the total suitable area will increase. In general, under future climate change, the suitable habitat for C. lineare will gradually migrate to the west and north, and its total suitable area will also expand. The results of this experiment can be used for the conservation and management of the wild resources of C. lineare. We can choose suitable growth areas to protect the medicinal resources of C. lineare through in situ conservation and artificial breeding.
Pressure overload is associated with right ventricular dyssynchrony in heart failure with reduced ejection fraction
Authors: Monzo Luca , Tupy Marek , Borlaug Barry A. , Reichenbach Adrian , Jurcova Ivana , Benes Jan , Mlateckova Lenka , Ters Jiri , Kautzner Josef , Melenovsky Vojtech 
Published: January 2024

AbstractAimsThe determinants and relevance of right ventricular (RV) mechanical dyssynchrony in heart failure with reduced ejection fraction (HFrEF) are poorly understood. We hypothesized that increased afterload may adversely affect the synchrony of RV contraction.Methods and resultsA total of 148 patients with HFrEF and 36 controls underwent echocardiography, right heart catheterization, and gated single‐photon emission computed tomography to measure RV chamber volumes and mechanical dyssynchrony (phase standard deviation of systolic displacement timing). Exams were repeated after preload (N = 135) and afterload (N = 15) modulation. Patients with HFrEF showed higher RV dyssynchrony compared with controls (40.6 ± 17.5° vs. 27.8 ± 9.1°, P < 0.001). The magnitude of RV dyssynchrony in HFrEF correlated with larger RV and left ventricular (LV) volumes, lower RV ejection fraction (RVEF) and LV ejection fraction, reduced intrinsic contractility, increased heart rate, higher pulmonary artery (PA) load, and impaired RV–PA coupling (all P ≤ 0.01). Low RVEF was the strongest predictor of RV dyssynchrony. Left bundle branch block (BBB) was associated with greater RV dyssynchrony than right BBB, regardless of QRS duration. RV afterload reduction by sildenafil improved RV dyssynchrony (P = 0.004), whereas preload change with passive leg raise had modest effect. Patients in the highest tertiles of RV dyssynchrony had an increased risk of adverse clinical events compared with those in the lower tertile [T2/T3 vs. T1: hazard ratio 1.98 (95% confidence interval 1.20–3.24), P = 0.007].ConclusionsRV dyssynchrony is associated with RV remodelling, dysfunction, adverse haemodynamics, and greater risk for adverse clinical events. RV dyssynchrony is mitigated by acute RV afterload reduction and could be a potential therapeutic target to improve RV performance in HFrEF.
Morphological modulation enabled by non‐halogenated solvent‐processed simple solid additives for high‐efficiency organic solar cells
Authors: Haris Muhammad , Ryu Du Hyeon , Ullah Zakir , Kang Bong Joo , Jeon Nam Joong , Lee Seungjin , Lee Hang Ken , Lee Sang Kyu , Lee Jong‐Cheol , Kwon Hyung‐Wook , Shin Won Suk , Song Chang Eun 
Published: January 2024

AbstractThe simple‐structural and volatile solid additive 1,4‐dibromobenzene (DBrB) can outperform organic solar cells (OSCs) fabricated with 1,4‐diiodobenzene and 1,4‐dichlorobenzene in terms of power conversion efficiency (PCE). A remarkable PCE of 17.0% has been achieved in a binary OSC based on DBrB‐optimized photoactive materials processed from non‐halogenated solvents, which is mainly attributed to the formation of a three‐dimensional interpenetrating network and the orderly arrangement of the photoactive materials by improving the intermolecular interaction. This optimized morphology enables efficient charge transfer/transport as well as suppressed charge recombination, resulting in the simultaneous increase in all photovoltaic parameters. More importantly, we demonstrate that non‐halogenated solvent‐processed DBrB enabled PM6:Y6‐HU OSCs with an impressive PCE of 18.6%, which is the highest efficiency yet reported for binary OSCs. This study suggests that the novel DBrB volatile solid additive is an effective approach to optimizing the morphology and thereby improves the photovoltaic performance of OSCs.image
Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies
Authors: Zheng Bing , Zhao Xiaole , Ao Tianxiang , Xie Jianhua , Chen Yi , Gui Yueyao , Gao Xingcai , Hu Xiaobo , Yu Qiang 
Published: January 2024

AbstractThis study aimed to investigate the anti‐obesity mechanisms of rice bran total dietary fiber (RDF), rice bran insoluble DF (RIDF), and rice bran soluble DF (RSDF) from defatted rice bran. RDF, RIDF, and RSDF exhibited excellent anti‐obesity effects, mainly reflected in lipid adsorption in vitro, reduction of body weight, inhibition of adipose tissue accumulation, improvement of dyslipidemia, and repair of histopathological damage. More importantly, the analysis of multi‐omics results revealed that the regulation of intestinal microbiota, amino acid metabolism, and lipid metabolism were the critical pathways for the anti‐obesity effects of RDF, RIDF, and RSDF. However, RIDF was involved in lipid metabolism through alanine, aspartate, and glutamate metabolism and exhibited a more favorable regulatory effect on gut microbiota. In contrast, RSDF impacted metabolic pathways dominated by tryptophan and cholesterol metabolism and excelled in immune and inflammatory amelioration. RIDF and RSDF together constitute RDF, with the latter integrating the tendencies of RIDF and RSDF in terms of intestinal microbiota and hepatic gene expression. However, RDF exhibited significant differences in metabolic regulation compared to RIDF and RSDF, particularly concerning tryptophan metabolism. These findings demonstrated that RIDF and RSDF have distinct mechanisms in obesity management, and that both contributed differently to the anti‐obesity effect of RDF. This study provides experimental evidence for the development of different types of DF from defatted rice bran as personalized anti‐obesity dietary supplements. It also offers new insights for future precision nutrition interventions involving DF.
Trisomy 13 with retroiliac ureter diagnosed by assessment for recurrent febrile urinary tract infections
Authors: Morizawa Yosuke , Tomizawa Mitsuru , Shimizu Takuto , Onishi Kenta , Hori Shunta , Gotoh Daisuke , Nakai Yasushi , Miyake Makito , Torimoto Kazumasa , Fujimoto Kiyohide 
Published: January 2024

IntroductionPatients with trisomy 13 have multiple malformations, including urological anomalies, and severe cognitive and psychomotor disabilities. We conducted a ureteroureterostomy for a mid‐ureteral stricture due to a retroiliac ureter in a patient with trisomy 13.Case presentationA 6‐month‐old girl with trisomy 13 developed a urinary tract infection. Computed tomography for assessing recurrent urinary tract infection revealed a left mid‐ureteral stricture due to the retroiliac ureter. At the age of 2, a ureteroureterostomy was performed. Two years after surgery, the urinary tract infection did not recur.ConclusionUreteroureterostomy is a safe procedure for children with trisomy 13 and multiple comorbidities. Surgical treatment should be considered for patients with trisomy 13 when agreed upon by the family and comorbidities are well‐controlled.
The cooperative development relationship between Nature Reserves and local communities
Authors: Guo Xueyan , Huang Zhongde , Bai Yang , Lian Yiwei , Yang Wei , Lu Xinyao , Shi Wei , Wu Naiju , Turi Maroof Ali 
Published: January 2024

AbstractThe coordinated relationship between Nature Reserves (NRs) and adjacent communities has a significant impact on both these local communities and conservation management practices. However, the precise relationship between NRs and their surrounding communities remains poorly understood, whether it is coordinated or unbalanced? This study employed a matrix analysis approach alongside a coordination degree model to assess the relationship and the degree of coordination between the Xiaoheishan NRs (Xhs NRs) and local communities. In addition, a structural equation model was used to analyze the factors that influence the degree of coordination between the Xhs NRs and adjacent communities. Taking into account the willingness of these communities, a prospective development model was proposed. The results of the study revealed that: (1) the relationship between the Xhs NRs and their surrounding communities was predominantly characterized by a protection‐oriented approach, particularly in the subprotected regions of Xhs, Dxs, and Jzs. (2) The path analysis revealed that the level of dependence, knowledge, and cost perception among the Xhs NRs communities had a direct negative influence on the degree of coordination. Conversely, the attitudes and perceived benefits to the Xhs NRs had a direct positive effect. (3) The pathway to future development involves a triple model approach: a public participation model, an economic model that focuses on mutual benefits and a protection and poverty alleviation model. The relationship between NRs and surrounding communities should be accurately defined; and the contradiction between protection and development should be fully coordinated. To achieve coordinated development of NRs and communities that reside close by, the Xhs NRs, along with other smaller and scattered NRs, should actively involve the public, particularly local communities, in conservation management.
Hotspots of zoonotic disease risk from wildlife hunting and trade in the tropics
Authors: Choo Jacqueline , Nghiem Le T. P. , Chng Serene , Carrasco Luis R. , Benítez‐López Ana 
Published: January 2024

AbstractWildlife hunting and trade creates numerous direct human–animal contact opportunities that can facilitate transmission of zoonotic diseases pantropically. Yet, there is a lack of knowledge of which species and areas have a high risk of zoonotic disease spillover due to wildlife hunting and trade. We combined maps of hunting pressure, recent data sets on human‐shared pathogens, and trade volumes for 614 mammalian host species to map zoonotic disease risk from wildlife hunting and trade pantropically. We also assessed the relationship between zoonotic disease risk from hunting and probability of emerging zoonotic diseases using generalised least square regression. We identified hotspots of zoonotic disease risk from hunting in central America, China, and central Africa. When considering wildlife trade frequency, high risk occurs in southern Africa and China. Zoonotic disease risk from wildlife hunting aligns significantly with the risk of zoonotic emerging infectious diseases, suggesting that hunting is a key driver of zoonotic disease outbreaks of pandemic potential. Interventions that regulate the hunting of host species and considers the socioeconomic motivations behind hunting could reduce the risk of zoonotic disease spillover.
Cyberloafing deterrence in the public sector of Ghana
Authors: Kolog Emmanuel Awuni , Mensah Isaac , Egala Sulemana Bankuoru 
Published: January 2024

AbstractThe integration of the Internet into various aspects of business operations, including the public sector, is rapidly becoming a norm. However, within this evolving landscape, the issue of cyberloafing, the misuse of the internet for unauthorized activities, cannot be ignored. Existing research on cyberloafing in developing countries, specifically in Ghana, has predominantly focused on higher education students. A brief examination of the literature pertaining to cyberloafing in developing nations reveals a prevalent emphasis on categorizing cyberloafing activities, often with limited insight into the motivations and deterrence of such behavior. Drawing on the framework of the General Deterrence theory, this paper delves into the underlying factors that deter cyberloafing behavior within the public sector of Ghana. Through the utilization of a partial least square structural equation model, the study analyzed data from 473 responses collected from public institutions across Ghana. The study revealed that factors such as certainty, monitoring, and security risks significantly influence the manifestation of cyberloafing behavior among employees in the Ghanaian public sector. However, the Severity and Celerity of sanctions were found not to influence cyberloafing behavior. The moderating effect of age and culture on the deterrent constructs and cyberloafing behavior vary. The study serves as a strategic framework to curd the rampant cyberloafing activities in many public sector institutions particularly in the global south. In essence, this study contributes not only to the understanding of cyberloafing behavior in the Ghanaian public sector but also provides a valuable foundation for designing targeted interventions to address this issue, ultimately fostering a more productive and responsible online engagement within these institutions.
Asperuloside alleviates cyclophosphamide‐induced myelosuppression by promoting AMPK/mTOR pathway‐mediated autophagy
Authors: Che Hong , Li Linlin , Zhao Bingjie , Hu Lian , Xiao Li , Liu Peijia , Liu Songshan , Hou Zhufa 
Published: January 2024

AbstractCyclophosphamide (CTX) is a common anticancer chemotherapy drug, and myelosuppression is the most common serious side effect. Asperuloside (ASP), the active component of Hedyotis diffusa Willd., may have the effect of ameliorating chemotherapy‐induced myelosuppression. This study aimed to explore the effect and possible mechanism of ASP on CTX‐induced myelosuppression. Male SPF C57BL/6 mice were randomly divided into five groups: control group, CTX (25 mg/kg) group, CTX + granulocyte‐macrophage‐colony stimulating factor (GM‐CSF) (5 μg/kg) group, CTX + high‐dose ASP (50 mg/kg) group and CTX + low‐dose ASP (25 mg/kg) group, with six mice in each group. The body weight of mice was monitored every other day, the hematopoietic progenitor cell colony number was measured by colony forming unit, and the relevant blood indicators were detected. Femoral bone marrow was observed by hematoxylin‐eosin, C‐kit expression was detected by immunohistochemistry, and autophagy and adenine monophosphate‐activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway protein expressions were detected by immunohistochemistry and western blotting (WB). Then the AMPK inhibitor dorsomorphin was used to interfere with AMPK/mTOR pathway. Results showed that ASP significantly increased the body weight of CTX‐induced mice, increased the number of hematopoietic progenitor cells, the expression of white blood cells, red blood cells, platelets, GM‐CSF, thrombopoietin and erythropoietin in blood, and the expression of C‐kit in bone marrow. In addition, ASP further promoted the expression of Beclin1 and LC‐3II/I induced by CTX, and regulated the protein expressions in the AMPK/mTOR pathway. The use of dorsomorphin inhibited the alleviation effect of ASP on CTX‐induced myelosuppression and the promotion effect of ASP on autophagy. In conclusion, ASP alleviated CTX‐induced myelosuppression by promoting AMPK/mTOR pathway‐mediated autophagy.
Time series analysis in preventive intervention research: A step‐by‐step guide
Authors: Dorais Stephanie 
Published: January 2024

AbstractTime series analysis (TSA) is a statistical approach rooted in data mining that measures outcomes that consistently fluctuate over time. It is uniquely positioned as a methodology for preventive intervention research due to its capacity to measure long‐term impact in natural settings. With the ability to detect temporal patterns in a series of chronological data points, it allows researchers to detect naturalistic patterns, forecast future observations, and explain a change in data after an intervention is put in place. However, its application is historically sparse across behavioral research. This article provides counseling researchers with an overview of TSA and presents a step‐by‐step guide for conducting TSA analyses in counseling research. The author discusses the key concepts, steps for implementation, and the strengths and challenges of conducting TSA.
Predictive potential of K‐Banhatti and Zagreb type molecular descriptors in structure–property relationship analysis of some novel drug molecules
Authors: Ullah Asad , Jabeen Safina , Zaman Shahid , Hamraz Anila , Meherban Summeira 
Published: January 2024

AbstractTopological indices (TIs) can be used to forecast molecules' biological activity, physicochemical features, and toxicity. The use of topological indices and regression analysis can help us better understand drug behavior and contribute to the development of tailored drugs. This study investigates the predictive potential and efficacy of K‐Banhatti and Zagreb type degree‐based topological indices in quantitative structure–property relationship (QSPR) analysis of a comprehensive set of medications used for diabetes type‐I and type‐II disease. The K‐Banhatti and Zagreb type degree‐based topological indices are computed for 14 anti‐diabetes drug molecules using edge/vertex partitioning techniques. By leveraging these topological indices, QSPR regression models are developed to predict the physicochemical properties of the understudy drugs. The results show that the values of these topological indices are highly correlated with certain physicochemical properties of the anti‐diabetes drugs. Furthermore, the comparative analysis revealed that, for all the considered properties except enthalpy of vaporization, Zagreb type indices outperform K‐Banhatti indices with high predictive ability. Hence, it can be concluded that the Zagreb type indices are the best alternatives to theoretically predict the properties of anti‐diabetes drugs. This theoretical analysis can help chemists in their right choice of the topological indices to theoretically predict the properties of anti‐diabetes drugs without going into laborious experimentation.
The Use of Magnetic Resonance Imaging in Radiation Therapy Treatment Simulation and Planning
Authors: McGee Kiaran P. , Cao Minsong , Das Indra J. , Yu Victoria , Witte Robert J. , Kishan Amar U. , Valle Luca F. , Wiesinger Florian , De‐Colle Chiara , Cao Yue , Breen William G. , Traughber Bryan J. 
Published: January 2024

Ever since its introduction as a diagnostic imaging tool the potential of magnetic resonance imaging (MRI) in radiation therapy (RT) treatment simulation and planning has been recognized. Recent technical advances have addressed many of the impediments to use of this technology and as a result have resulted in rapid and growing adoption of MRI in RT. The purpose of this article is to provide a broad review of the multiple uses of MR in the RT treatment simulation and planning process, identify several of the most used clinical scenarios in which MR is integral to the simulation and planning process, highlight existing limitations and provide multiple unmet needs thereby highlighting opportunities for the diagnostic MR imaging community to contribute and collaborate with our oncology colleagues.Evidence Level5Technical EfficacyStage 5