bluuebunny/crossref_metadata_2025_split huggingface dataset:
A two‐stage robust optimal traffic signal control with reversible lane for isolated intersections
Authors: Sun Zhiyuan , Wang Zhicheng , Qi Xin , Wang Duo , Li Yue , Lu Huapu 
Published: December 2023

AbstractThe integrated design of traffic signal control (TSC) and reversible lane (RL) is an effective way to solve the problem of tidal congestion with uncertainty at isolated intersections, because of its advantage in making full use of temporal‐spatial transportation facilities. Considering the contradiction between the dynamic TSC scheme and the fixed RL scheme in one period, a two‐stage optimization method based on improved mean‐standard deviation (MSD) model for isolated intersections with historical and real‐time uncertain traffic flow is proposed. In the first stage, applying the same‐period historical data of multiple days, a robust optimal traffic signal control model with reversible lane based on MSD model (MSD‐RTR model) is put forward to obtain the fixed RL scheme and the compatible initial TSC scheme. A double‐layer nested genetic algorithm (DN‐GA) is designed to solve this model. In the second stage, applying real‐time period data and multi‐day same‐period historical data, a robust optimal dynamic traffic signal control model based on MSD model (MSD‐RDT model) is put forward to obtain the dynamic TSC scheme. Three modes which reflect the different weights of historical period and real‐time period in this MSD‐RDT model are presented to improve the model stability, and a multi‐mode genetic algorithm (MM‐GA) is designed. Finally, a case study is presented to demonstrate the efficiency and applicability of the proposed models and algorithms.
Fraud detection through data sharing using privacy‐preserving record linkage, digital signature (EdDSA), and the MinHash technique: Detect fraud using privacy preserving record links
Authors: Thomas Satish , Sluss James 
Published: December 2023

AbstractFraud is a persistent and increasing problem in the telecom industry. Telcos work in isolation to prevent fraud. Sharing information is critical for detecting and preventing fraud. The primary constraint on sharing information is privacy preservation. Several techniques have been developed to share data while preserving privacy using privacy‐preserving record linkage (PPRL). Most of the PPRL techniques use a similarity measure like Jacquard similarity on homologous datasets, which are all prone to graph‐based attacks, rendering existing methods insecure. Many complex and slow techniques use the Bloom filter implementation, which can be compromised in a cryptanalysis attack. This paper proposes an attack‐proof PPRL method using existing infrastructure of a telco without a complex multistep protocol. First, a novel way of matching two non‐homologous datasets using attack‐proof digital signature schemes, like the Edwards‐curve digital signature algorithm is proposed. Here, Jaccard similarity can only be estimated using this method and not on the datasets directly. Second, two parties transact with a simple request–reply method. To validate the match accuracy, privacy preservation, and performance of this approach, it was tested on a large public dataset (North Carolina Voter Database). This method is secure against attacks and achieves 100% match accuracy with improved performance.
Ages, metallicity, and α-enhancement of the globular cluster populations in NGC 3311
Authors: Grasser Natalie , Arnaboldi Magda , Barbosa Carlos Eduardo , Spiniello Chiara , Coccato Lodovico , Trevor Mendel John 
Published: December 2023

Aims. We aim to investigate the stellar population properties, ages, and metal content of the globular clusters (GCs) in NGC 3311, the central galaxy of the Hydra I cluster, to better constrain its evolution history.
Methods. We used integral-field spectroscopic data from the Multi-Unit Spectroscopic Explorer (MUSE) to identify 680 sources in the central region of NGC 3311 and extract their 1D spectra. An analysis of these sources in terms of morphologies, radial velocities, and emission lines allowed us to narrow down our selection to 49 bona fide GC candidates. We split these candidates into two groups depending on their projected distance to the galaxy center (R), namely inner (R ≤ 20″) and outer (R > 20″) GCs. We stacked the extracted 1D spectra of the inner and outer GC populations to increase the signal-to-noise ratios (S/Ns) of the resulting spectra and hence allow full-spectrum fitting. In addition, we also created a stacked spectrum of all GCs in NGC 3311 and one of the two most central GC candidates. Using the code pPXF, we performed a stellar population analysis on the four stacked 1D spectra, obtaining mass-weighted integrated ages, metallicities, and [α/Fe] abundances.
Results. All GCs are old, with ages ≥13.5 Gyr, and they have super-solar metallicities. Looking at the color distribution, we find that the inner ones tend to be redder and more metal-rich than the outer ones. This is consistent with the two-phase formation scenario. Looking at the full-spectral fitting results, at face value the outer GCs have a larger [α/Fe] ratio, which is in line with what is found for the stars that dominate the surface brightness profile at the same radii. However, the values for outer and inner GCs are consistent within the uncertainties. Interestingly, the stacked spectrum of the two most central GCs appears to have the highest metallicity and [α/Fe], although with larger uncertainties. They might be associated with the core progenitor of NGC 3311.
Conclusions. The careful analysis of the MUSE-extracted 1D spectra for compact sources in the center of NGC 3311 and its halo indicate that a significant fraction (28%) do display emission lines. Once they are removed, the selected bona fide GC candidates are old (≥13.5 Gyr) and have super-solar metallicities (slightly larger in the center) and [α/Fe] (slightly larger for the outer GCs). Stellar population analyses of the extracted spectra do not support the presence of an intermediate (a few Gigayears) GC population in the central 40 arcsec (10 kpc) radius of NGC 3311.
Die Suche nach dem „Knoten des Lebens“ – die Atemregulation
Authors: Koehler Ulrich , Degerli Mikail Aykut , Conradt Regina , Hildebrandt Olaf , Koehler Niklas , Hildebrandt Wulf 
Published: December 2023

Zusammenfassung
Der Artikel gibt einen geschichtlichen Überblick über die in den letzten beiden Jahrhunderten erfolgten Entwicklungen zum Verständnis des Atemrhythmus und seiner Kontrollmechanismen. Im 19. Jahrhundert wurde erstmalig eine Struktur in der Medulla oblongata als „Knoten des Lebens“ beschrieben. 1743 entdeckte Taube das Karotiskörperchen, 1927 hat der Spanier de Castro dessen Morphologie und Innervation beschrieben. Erst Vater und Sohn Heymans haben die physiologische und pharmakologische Bedeutung des Karotis- und Aortenkörperchens erkannt. Heute wissen wir, dass die Generierung und Kontrolle der Atmung durch ein komplexes neuronales Netzwerk im Hirnstamm erfolgt. Chemo-, Mechano- und Propriorezeptoren vermitteln Informationen aus Blut, Atemwegen und Muskeln in das respiratorische Netzwerk. Das Atemzentrum integriert die von den Rezeptoren, dem autonomen Nervensystem, dem Herz-Kreislauf-System sowie den willentlich vom zerebralen Kortex eingehenden Informationen und bemisst den Grad der respiratorischen Aktivierung von Motoneuronen und atmungsrelevanter Muskulatur.
Reexpansion pulmonary edema after treatment of primary spontaneous pneumothorax
Authors: Gleibs Fabian , Döllinger Felix , Witzenrath Martin , Huebner Ralf-Harto , Saccomanno Jacopo 
Published: December 2023

AbstractA 24-year-old male patient, without further symptoms or comorbidities presented to the emergency room with acute dyspnea after heavy lifting two days before. On auscultation an attenuated vesicular breath was noticed on the right lung. In the initial chest radiograph a right-sided primary spontaneous pneumothorax with minor mediastinal shift was diagnosed. After insertion of a 12-French chest tube the patient’s clinical condition deteriorated. The following chest radiograph and computed tomography of the thorax showed a reexpansion pulmonary edema in the right lung. The patient was admitted to the ICU and supportive treatment was initiated. Pulmonary reexpansion edema after drainage of a pneumothorax is a very rare complication with mortality rates reaching up to 20%. The exact pathophysiology remains unknown. Typical Symptoms include dyspnea, hypotension, and tachycardia. To minimize the risk of a pulmonary reexpansion edema, not more than 1200–1800 ml of air should be drained at once and the drainage should be stopped when the patient starts coughing.
Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid
Metabolism in Hyperlipidemic Mice
Authors: Cai Wenjuan , Wang Xin , Deng Qian , Gao Jian , Chen Yuqing 
Published: December 2023

AbstractHyperlipidemia is a common metabolic disorder that can lead to cardiovascular
disease. PDK4 is a key enzyme that regulates glucose and fatty acid metabolism
and homeostasis. The aim of this study is to explore the correlation between
PDK4 expression and dyslipidemia in obese children, and to find new therapeutic
targets for hyperlipidemia in children. The expression of PDK4 in serum was
detected by qRT-PCR. Receiver operating characteristic curve was used to analyze
the relationship between PDK4 and dyslipidemia. Upstream miRNAs of PDK4 were
predicted by the database and verified by dual luciferase reporter gene assay
and detected by qRT-PCR. The hyperlipidemia mouse model was established by
high-fat diet (HFD) feeding, and the metabolic disorders of mice were detected.
PDK4 is poorly expressed in the serum of obese children. The upstream of PDK4
may be inhibited by miR-107, miR-27a-3p, and miR-106b-5p, which are highly
expressed in the serum of obese children. Overexpression of PDK4 improves lipid
metabolism in HFD mice. miR-27a-3p silencing upregulates PDK4 to improve lipid
metabolism. In conclusion, PDK4 has a diagnostic effect on dyslipidemia in
children, while lipid metabolism in hyperlipidemic mice could be mitigated by
upregulation of PDK4, which was inhibited by miR-107, miR-27a-3p and miR-106b-5p
on upstream.
Modular Synthesis of Methyl-Substituted Novel Psoralen N-Hydroxysuccinimide Esters and Evaluation of DNA Photocrosslinking Properties of the Corresponding Triplex-Forming Oligonucleotide Conjugates
Authors: Mikame Yu , Maekawa Nagisa , Kimura Soichiro , Yamayoshi Asako , Nakao Juki 
Published: December 2023

AbstractPsoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been used to induce DNA mutations or to suppress gene expression through the formation of crosslinked products with DNA in a sequence-specific manner. Psoralen can crosslink with DNA at its furan-ring and/or pyrone-ring side, yielding either a monoadduct or diadduct (interstrand crosslinking) product. The differences in the crosslinked structures of Ps-TFOs with the target DNAs are closely related to the changes in the biological outcomes induced by the Ps-TFOs. However, only a few reports have discussed the photocrosslinking properties of Ps-TFOs. The photocrosslinking properties of Ps-TFOs with structurally diverse psoralen derivatives remain elusive. Herein, we report the modular synthesis of novel methyl-substituted psoralen N-hydroxysuccinimide (NHS) esters. By using these esters, the effect of the methyl substituent of psoralen on the photocrosslinking of the corresponding Ps-TFOs was examined. The amount of the diadduct product was significantly reduced in the presence of methyl substituents at the C-3 and C-4 positions, while the total amount of photocrosslinking product was maintained. This work demonstrates the possibility of controlling the crosslinked product of Ps-TFOs by introducing methyl groups into psoralen: this ability to manipulate the product is an important factor in the biological applications of Ps-TFOs.
Atroposelective Construction of Tetrasubstituted Axially Chiral Alkene Frameworks
Authors: He Ying , Zou Jia-Yu , Xu Wan-Yi , Wang Jie , Liu Qi 
Published: December 2023

AbstractThe construction of axially chiral alkene frameworks is currently one of hottest topics in the field of organic synthetic chemistry. Compared to traditional axially chiral molecules, such as biaryls, heterobiaryls, and anilides, the synthesis of axially chiral alkenes is far more challenging, especially for acyclic tetrasubstituted alkene analogues. In this review, we summarized the development of strategies for the synthesis of tetrasubstituted axially chiral alkene analogues, including asymmetric difunctionalization, C–H functionalization, cross-coupling, (dynamic) kinetic resolution, and asymmetric allylic substitution-isomerization.1	Introduction2	Synthesis of Cyclic Tetrasubstituted Axially Chiral Alkenes3	Synthesis of Acyclic Tetrasubstituted Axially Chiral Alkenes4	Summary and Outlook
Chiral Bifunctional NHC–Guanidine Ligands for Asymmetric Hydrogenation
Authors: Teichert Johannes F. , Gorai Mahadeb 
Published: December 2023

AbstractWe report the synthesis of chiral N-heterocyclic carbene/guanidine bifunctional ligands from readily available amino alcohols. The resulting chiral bifunctional copper(I) complexes are active catalysts in an asymmetric hydrogenation of ketones. We show that the chiral linker unit can be employed for the transfer of stereoinformation.
The Association between Mode of Transportation Support and Research Study Visit Attendance among Pregnant Patients
Authors: Vinson Ariel , Paul Rachel , Chubiz Jessica , Raghuraman Nandini , Kelly Jeannie C. , England Sarah K. , Carter Ebony B. 
Published: December 2023

Objective This study aimed to examine the association between transportation assistance and study visits, and explore differences by transportation modality.
Study Design This was a secondary analysis of prospective cohort study. We identified patients requesting transportation support for research ultrasound visits and identified controls (1:2 ratio) who did not request support matched for age, race, and insurance type. Conditional logistic regression examined the association between transportation support and mode of transportation with study visit attendance.
Results Transportation support was requested by 57/1,184 (4.8%) participants. Participants that requested transportation support were three times more likely to attend visits than their matched controls (adjusted odds ratio [aOR] = 3.16, 95% confidence interval [CI]: 1.76–5.68). Among visits with transportation support, those supported by a ridesharing service had five-fold higher odds of attendance than visits supported with taxi service (aOR = 5.06, 95% CI: 1.50–16.98).
Conclusion Transportation support, especially a ridesharing service, is associated with improved attendance at research study visits in a sample of predominantly low-income, Black, pregnant participants. Implementing transportation support may be a promising strategy to improve engagement in research studies.
Key Points
Feasibility of Universal Screening for Preeclampsia Risk and Aspirin Recommendation in the Ultrasound Unit
Authors: Pimentel Verónica Maria , Larrea Alexander D. Almeida , Renaud Sophie J. , Sloan Sophie , Figueroa Reinaldo , Wakefield Dorothy , Crowell Rebecca 
Published: December 2023

Objective To evaluate the feasibility and impact of using the first-trimester ultrasound visit to identify and counsel women at increased risk of preeclampsia about the benefits of low-dose aspirin (LDA) for preventing preeclampsia. We also assessed patient-reported utilization of LDA, perceived risk for preeclampsia, and clinical outcomes.
Study Design Women presenting for routine first-trimester nuchal-translucency (NT) ultrasounds were screened for clinical preeclampsia risks using a self-administered risk assessment. Women at moderate or high risk for preeclampsia were counseled to take LDA, if not already taking it. LDA utilization and perceived risk for preeclampsia were assessed during the second-trimester ultrasound. Factors associated with LDA utilization were analyzed. Pregnancy outcomes were compared between those who used LDA and those who did not.
Results Slightly more than 20% of patients (765/3,669) screened at increased risk for developing preeclampsia. Of those, 67.8% (519/765) had not received LDA recommendations from their referring obstetrician and 97 had not been taking LDA despite being advised to do so. Combined, 94.6% (583/616) of these patients eligible to start LDA prophylaxis received the indicated counseling during the ultrasound visit. A total of 61.4% (358/583) of women completed the follow-up form and of those 77.9% (279/358) reported taking LDA. Screening at increased risk for preeclampsia and perception of increased risk were positively associated with LDA utilization, whereas concerns for LDA safety were negatively associated with use. African American/Black patients and Medicaid recipients were less likely to use LDA. Pregnancy outcomes were similar between those who used LDA and those who did not.
Conclusion Assessing preeclampsia risk and counseling patients about LDA at the time of the NT ultrasound are feasible in the ultrasound unit and led to good LDA utilization among women at increased risk for preeclampsia. This intervention may standardize patient care and help close the disparity in maternal health.
Key Points
How Did the COVID-19 Pandemic Affect Maternal and Neonatal Health?
Authors: Dogan Nazan N. , Salihoglu Ozgul 
Published: December 2023

Objective The aim of this study was to investigate the effects of the coronavirus disease 2019 (COVID-19) pandemic on the proportional growth of the fetus, maternal health, and neonatal outcomes.
Study Design The study group (Group 1) included pregnant women with a history of COVID-19. Pregnant women who were hospitalized during the same period without COVID-19 were the control group (Group 2). Maternal and neonatal outcomes were compared between the groups.
Results A total of 230 pregnant women and their infants were assessed. Group 1 (n = 74) had significantly higher rates of diabetes mellitus and hypertension than Group 2 (n = 156; p = 0.015 and 0.014, respectively). Premature birth and cesarean section rates were also significantly higher in Group 1 than in Group 2 (p = 0.001 and 0.040, respectively). While the rate of iatrogenic preterm birth was significantly higher in Group 1, the rate of spontaneous preterm birth was significantly higher in Group 2 (p = 0.049). Infants born to COVID-19-positive mothers had lower median gestational age, birth weight, and Apgar scores (p < 0.01). There was no significant difference between the groups in terms of the results of cord blood gas analysis (p > 0.05). The rate of admission to the neonatal intensive care unit (NICU) and need for mechanical ventilation was significantly higher in infants of COVID-19-positive mothers (p < 0.05 for both). The length of stay in the NICU was also significantly longer for the infants of COVID-19-positive mothers (p < 0.05). Birth weights decreased due to increased cases of iatrogenic preterm births (p < 0.05). However, ponderal indices (PIs) of newborns of pregnant COVID-19 mothers did not differ at birth (p > 0.05).
Conclusion COVID-19 is associated with low Apgar scores, increased risk of premature birth complications, and maternal comorbidities, with no effect on the PI and proportionate growth of the infant at birth.
Key Points
How Many Patients Qualify for Extended Oral Antibiotic Prophylaxis Infection Following Primary and Revision Hip and Knee Arthroplasties?
Authors: Potter Genna R. , Feuchtenberger Bennett W. , Sowinski Halee N. , Roberts Austin J. , Siegel Eric R. , Dietz Matthew J. , Stambough Jeffery B. , Bedard Nicholas A. , Mears Simon C. 
Published: December 2023

AbstractExtended oral antibiotic prophylaxis (EOAP) has been suggested to reduce rates of periprosthetic joint infection (PJI) postoperatively after total joint arthroplasty (TJA). The purpose of this multicenter study is to define how many TJA patients are considered high risk for developing PJI based on published EOAP criteria and determine whether this status is associated with socioeconomic or demographic factors. All primary and aseptic revision TJAs performed in 2019 at three academic medical centers were reviewed. High-risk status was defined based on prior published EOAP criteria. Area deprivation index (ADI) was calculated as a measure of socioeconomic status. Data were reported as means with standard deviation. Both overall and institutional differences were compared. Of the 2,511 patients (2,042 primary and 469 revision) in this cohort, 73.3% met criteria for high risk (primary: 72.9% [1,490] and revision: 74.6% [350]). Patient's race or age did not have a significant impact on risk designation; however, a larger proportion of high-risk patients were women (p = 0.002) and had higher Elixhauser scores (p < 0.001). The mean ADI for high-risk patients was higher (more disadvantaged) than for standard-risk patients (64.0 [20.8] vs. 59.4 [59.4]) (p < 0.001). Over 72% of primary and revision TJA patients at three medical centers met published criteria for EOAP. These patients were more often women, had more comorbidities, and lived in more disadvantaged areas. Our findings suggest that most patients qualify for EOAP, which may call for more stringent criteria on who would benefit extended antibiotic prophylaxis.
Conceptualising care: critical perspectives on informal care and inequality
Authors: Peterie Michelle , Broom Alex 
Published: December 2023

AbstractInformal care occupies a paradoxical place in contemporary societies. It is at once reified as an inherent social good, and minimised, devalued, and pushed to the margins. The current ‘care crisis’ is bringing these tensions into sharp relief, fuelling renewed interest in care and its absences across a wide range of disciplines. In this article, we present an overview of five key literatures for comprehending informal care, with a focus on issues of inequality and injustice. These bodies of scholarship—which, respectively, emphasise the political-economic, affective, policy, geographic, and ecological dimensions of informal care—together furnish a critical conceptualisation of informal care that both recognises care’s social value, and underlines its embeddedness in systems and structures of oppression. Informal care, we show, evades easy definition, requiring a sophisticated array of critical concepts to capture its everyday complexities, avoid reductionism, and ultimately enable individual and collective flourishing.