bluuebunny/crossref_metadata_2025_split huggingface dataset:
PANoptosis‑related signature for clear cell renal cell carcinoma in the context of monocyte and based on a 101‑combination machine learning computational framework
Authors: wang guojun , pu xiaofeng , feng bimin , huang gang , fan chao , luo zhiming , wang xin , zhang zhengji 
Published: January 2024

Abstract
Background
Clear cell renal cell carcinoma (ccRCC), a common cancer type, is significantly impacted by PANoptosis, an inflammatory-programmed cell death. A key research gap is the role of PANoptosis and mRNA in ccRCC, particularly from a single-cell perspective.The lack of a reliable prognostic biomarker undermines the efficacy of its predictive, preventive, and personalized medicine (PPPM/3PM) approach.
Method
We used scRNA-seq datasets from the GEO database to annotate ccRCC cell types based on marker gene expression and pan-apoptotic activity scores. Using various analysis techniques, including machine learning, we investigated single-cell level regulatory mechanisms. This enabled the development of new immune-related prognostic indicators by pinpointing specific markers in targeted cell populations.
Results
We developed a nine-gene monocyte-related score (MRS) that predicts overall survival in Kidney Renal Clear Cell Carcinoma (KIRC). MRS outperforms traditional clinical variables and molecular characteristics in accuracy, reflecting key prognostic information such as age, staging, metastasis, and mutations. Our comprehensive analysis provided numerous insights, enhancing our understanding of the interregulatory roles in PANoptosis progression in KIRC. Our conclusions are consistent with prior research on PANoptosis and KIRC. MRS is seen as an effective tool for benefiting KIRC patients.
Conclusion
Our study constructed the PANoptosis progression-related signature that can serve as a promising tool for prognosis prediction, targeted prevention, and personalized medicine in ccRCC. Incorporating PANoptosis into the PPPM framework
will provide a unique opportunity for clinical intelligence and new management approaches.
Craniotomy in Semi-Sitting Position: A 4-year Single Institution Experience
Authors: Karmakar Arunabha , Khan Muhammad Jaffar , Saracoglu Ayten , Ergenc Merve , Hussein Mogahed Ismail Hassan , Janish Mohammed , Saracoglu Kemal Tolga , Gangineni Kishore Kumar , Kumar Neeraj 
Published: January 2024

Abstract
Objectives
The aim of our study was to determine patient outcomes after surgery performed in the semi-sitting position in our institution in the previous 4 years. Primarily we aimed to quantify our experience in terms of surgical and anesthesia (clinical) outcomes. Secondarily we sought to evaluate any major complications that may have occurred.
Background
We are an academic hospital where the neurosurgical case load on average exceeds 1000 surgeries annually, with strong adherence to internationally determined clinical quality metrics. A multidisciplinary team comprising dedicated neuroanesthetists, neurophysiologists and surgical nurses, delivers care for every neurosurgical patient. As part of our neuroanesthesia departmental self-review, we retrospectively sought to assess the outcomes of patients undergoing craniotomy in sitting position from 2019 to present. The study focused on perioperative outcomes and complications associated with craniotomy in sitting position.
Method
The electronic medical record database was retrospectively reviewed. Beginning from 2019, all adult patients who underwent craniotomy in sitting position were included. Individual patient charts were examined for significant events during the intraoperative and postoperative period. Any critical or adverse events were recorded. Demographic and clinically important findings were tabulated in an excel sheet. The study dataset was descriptively analyzed with the quantitative data represented as mean ± standard deviation and the qualitative data as valid percentages from the total cohort. A possible parametric comparison of gender vs length of ICU stay, length of hospital stay and duration of was done using student T-test were found be non-significance at 95% confidence level. All the analysis was carried out using IBM Statistical Package for the Social Sciences (SPSS) ® Edition 22.
Results
A total of 10 patients underwent craniotomy in sitting position from 2019 till date. Induction and maintenance of general anesthesia were accomplished with total intravenous anesthesia using target-controlled infusion with remifentanil and propofol. The patients’ demographics, diagnosis and complications were evaluated. Nine of 10 patients had pneumocephalus with one patient developing severe manifestations. One patient had clinically significant venous air embolism with severe manifestations including massive pleural effusion. Except for one patient, all were extubated at end of surgery.
Conclusions
During the last four years our neuroanesthesia team recorded 10 craniotomies in sitting position. Ninety percent of patients were managed without any major long-term sequelae. We concluded that sitting position for craniotomy is not without its challenges. However, a dedicated and experienced team can manage possible complications and improve patient outcomes.
Vasopressin increases Cerebral Perfusion Pressure but not Cerebral Blood Flow in Neurosurgical Patients with Norepinephrine-Refractory Hypotension: A Preliminary Evaluation using the non-invasive Quantix ND in Comparison to the Literature
Authors: Bele Sylvia , Bründl Elisabeth , Schmidt Nils Ole , Kieninger Martin 
Published: January 2024

Abstract
The maintenance of sufficient mean arterial pressure (MAP) to sustain perfusion and oxygen delivery to all major organs is important patients in intensive care but for neurosurgical patients after SAH or TBI it is essential to avoid secondary brain damage or delayed ischemia. So far most neurosurgical intensive care units use intracranial pressure (ICP) and cerebral perfusion pressure (CPP) as therapy guidance for those patients. Use of fluid resuscitation and norepinephrine is standard to achieve CPP between 50–70 mmHg. But sometimes norepinephrine-refractory hypotension occurs. In those cases, arginin-vasopressin (AVP) is often the drug of choice. AVP and its synthetic analogies are widely used in modern medicine and gained interest in treatment of septic shock or refractory hypotension after cardiac surgery or hypovolemic shock. Recent papers also showed a significant impact of AVP in resuscitation of after traumatic brain injury (TBI) and influence on CPP in TBI patients during ICU treatment. But little is known about the effects of AVP on cerebral perfusion and oxygenation. The present preliminary study was carried out to examine the influence of vasopressin administration on cerebral blood flow by using the non-invasive QuantixND® device. We found significantly increased MAP and CPP but no concomitant elevation in CBF. In contrast, in most patients the CBF even decreased despite elevation of CPP. We conclude that AVP is an alternative drug to maintain MAP and CPP but must be used with care in patients with already compromised cerebral perfusion.
Impact of the annular solar eclipse on December 26, 2019 on the foraging visits of bees
Authors: Sinu Palatty Allesh , Jose Athira , Varma Sangeetha 
Published: January 2024

Abstract

Solar eclipse has remarkable effect on behavior of animals. South India experienced a 97% magnitude annular eclipse on December 26, 2019 during 0804 h-1104 h with the totality phase appeared during 0925–0930 h. We investigated the effect of this eclipse on foraging activity of bees to understand how a group of insects that rely the Sun, the sunlight, and the sun rays a lot for their navigation and vision behave to the eclipse. We opted to watch the bees in their foraging ground, and selected the natural flower populations of Cleome rutidosperma, Hygrophila schulli, Mimosa pudica, and Urena sinuata – the major bee-friendly plants – to record the visitor richness, visitation rate on the flowers on eclipse and non-eclipse days and during the hour of totality phase and partial phase of the eclipse. The plants received visits of nineteen and eleven species of bees, respectively on non-eclipse and eclipse days, but in the period of totality only three species of bees were active, but only in one population of C. rutidosperma. Visits of honey bees and stingless bees are affected most, but not that badly for solitary bees and carpenter bees. Bees, particularly the social bees use sun for navigation and deciphering information on food availability to fellow workers. The eclipse like for many other animals may hamper bees’ orientation, vision, and flight.
Genome assembly of Medicago truncatula accession HM078 provides insight into spring black stem and leaf spot disease resistance
Authors: Botkin Jacob , Farmer Andrew D. , Young Nevin D. , Curtin Shaun J. 
Published: January 2024

Abstract
Medicago truncatula, model legume and alfalfa relative, has served as an essential resource for advancing our understanding of legume physiology, functional genetics, and crop improvement traits. Necrotrophic fungus, Ascochyta medicaginicola, the causal agent of spring black stem (SBS) and leaf spot is a devasting foliar disease of alfalfa affecting stand survival, yield, and forage quality. Host resistance to SBS disease is poorly understood, and control methods rely on cultural practices. Resistance has been observed in M. truncatula accession HM078 with two recessively inherited quantitative-trait loci (QTL), rnpm1 and rnpm2, previously reported. To shed light on host resistance, we carried out a de novo genome assembly of HM078. The genome, referred to as MtHM078 v1.0, is comprised of 23 contigs totaling 481.19 Mbp. Notably, this assembly contains a substantial amount of novel centromere-related repeat sequences due to deep long-read sequencing. Genome annotation resulted in 98.4% of BUSCO fabales proteins being complete. The assembly enabled sequence-level analysis of rnpm1 and rnpm2 for gene content, synteny, and structural variation between SBS-resistant accession HM078 and SBS-susceptible accession A17. Fourteen candidate genes were identified, and some have been implicated in resistance to necrotrophic fungi. Especially interesting candidates include loss-of-function events in HM078 because they fit the inverse gene-for-gene model, where resistance is recessively inherited. In rnpm1, these include a loss-of-function in a disease resistance gene due to a premature stop codon, and a 10.85 kbp retrotransposon-like insertion disrupting a ubiquitin conjugating E2. In rnpm2, we identified a frameshift mutation causing a loss-of-function in a glycosidase, as well as a missense and frameshift mutation altering an F-box family protein. This study generated a high-quality genome of HM078 and has identified promising candidates, that once validated, could be further studied in alfalfa to enhance disease resistance.
Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity
Authors: Davis Zachary , Busch Alexandra , Steward Christopher , Muller Lyle , Reynolds John 
Published: January 2024

Abstract
Intrinsic, ongoing fluctuations of cortical activity form traveling waves that modulate the gain of sensory-evoked responses and perceptual sensitivity. Several lines of evidence suggest that intrinsic traveling waves (iTWs) may arise, in part, from the coordination of synaptic activity through the recurrent horizontal connectivity within cortical areas, which include long range patchy connections that link neurons with shared feature preferences. In a spiking network model with anatomical topology that incorporates feature-selective patchy connections, which we call the Balanced Patchy Network (BPN), we observe repeated iTWs, which we refer to as motifs. In the model, motifs stem from fluctuations in the excitability of like-tuned neurons that result from shifts in E/I balance as action potentials traverse these patchy connections. To test if feature-selective motifs occur in vivo, we examined data previously recorded using multielectrode arrays in Area MT of marmosets trained to perform a threshold visual detection task. Using a newly developed method for comparing the similarity of wave patterns we found that some iTWs can be grouped into motifs. As predicted by the BPN, many of these motifs are feature selective, exhibiting direction-selective modulations in ongoing spiking activity. Further, motifs modulate the gain of the response evoked by a target and perceptual sensitivity to the target if the target matches the preference of the motif. These results provide evidence that iTWs are shaped by the patterns of horizontal fiber projections in the cortex and that patchy connections enable iTWs to regulate neural and perceptual sensitivity in a feature selective manner.
Medication Administration Errors Among Children Admitted at a Regional Hospital in Northern Ghana: A Cross-Sectional Study
Authors: Wuni Francis Kwaku , Saanwie Aiden Suntaa , Dzotsi Emmanuel Kofi , Aborah Samuel , Amoateng Saffoh Samuel , Yakubu Zakaria , Anyoka Catherine 
Published: January 2024

Abstract
Background: Errors in medication administration have a number of detrimental effects, including delayed healing, drug resistance, morbidity, and even mortality, particularly in children.However, there are limited empirical data on the incidence of medication administration errors experienced by children admitted to healthcare facilities in Ghana.
Methods: A cross-sectional survey was used to obtain data from 399 sick children admitted to the Upper East Regional Hospital in Ghana to assess medication administration errors. Both descriptive and inferential statistical analyses such as Pearson chi-square tests and binary logistic regression,were also conducted.
Results: The incidence of medication administration errors was 65.9%. The intravenous route of medication was the most common route involved in medication administration errors (48.1%). An incorrect frequency of drug administration (41.9%) was the most common type of error. However, there were significant correlations between the occurrence of medication administration errors and hospital ward (p<0.001), age (p<0.001) and patient weight (p<0.05).
Conclusion:Children admitted to healthcare facilities are more likely to receive medication administration errors.
Study on the key parameters of ice particle air jet ejector structure
Authors: Man WANG , Zehua NIU , LIU Yong 
Published: January 2024

Abstract
The existing ice particle jet surface treatment technology is prone to ice particle adhesion during application, which seriously affects the surface treatment efficiency. Based on the basic structure of the jet pump, the ice particle air jet surface treatment technology is proposed for the instant preparation and utilization of ice particles, which solves the problem of ice particle adhesion and clogging. In order to realize the efficient utilization of ice particles and the high-speed jetting of ice air jet, the integrated jet structure of ice particle ejection and acceleration was developed. The influence of the working nozzle position (Ld), expansion ratio (n) and acceleration nozzle diameter ratio (Dn), length-to-diameter ratio (Ln) on the ice particle ejection and acceleration was systematically studied, and the structural parameters of the injector were determined with the impact kinetic energy of ice particles as the comprehensive evaluation index, and the surface treatment test was carried out to verify the results. The results of the study show that: under 2 MPa air pressure, the ejector nozzle parameters of n = 1.5, Dn=4.0, Ld=4, Ln=0 mm, can be sufficiently ejected to accelerate the ice particles. The structure parameters of the aluminum alloy plate depainting test, can obtain a larger radius of paint removal and make the aluminum alloy plate surface smoother, aluminum alloy surface roughness from 3.194 ± 0.489 m to 1.156 ± 0.136 m. The immediate preparation and utilization of ice particles, solved the problem of ice particles in the engineering application of air jet technology, ice particles bonding and storage problems. The instantaneous preparation and utilization of ice particles solves the problems of ice particle adhesion and storage in the engineering application of ice particle air jet technology, and can provide a feasible technical method in the field of material surface treatment.
Monitoring of Klebsiella pneumoniae infection and drug resistance in 17 pediatric intensive care units in China from 2016 to 2022
Authors: Fan Panpan , Fu Pan , Liu Jing , Zhang Xiaolei , Wang Yixue , Zhang Yingying , Zhu Ting , Zhang Caiyan , Wang Chuanqing , Lu Guoping , Yan Gangfeng , Group the China paediatric Intensive care Unit Pathogen Surveillan 
Published: January 2024

Abstract
Objective
To investigate the characteristics and drug resistance patterns of Klebsiella pneumoniae (KPN) infection among children admitted to pediatric intensive care unit (PICU).
Methods
KPN strains obtained from 17 domestic PICUs between January 1, 2016, and December 31, 2022, were collected for analysis. The overall condition and drug resistance patterns were assessed utilizing the WHO-NET software.
Results
A total of 26613 strains were identified, and 2591 (9.7%) KPN strains were isolated. Among which, carbapenem-resistant Klebsiella pneumoniae strains constituted 32.3%. The primary sites of KPN detection were the respiratory tract (71.1%), blood (8.6%), and urinary tract (7.1%). KPN’s resistance to penicillin drugs exceeded 90%. The resistance rate to amoxicillin-clavulanic acid declined from 70–48%, whereas it remained relatively stable at approximately 31–33% for piperacillin-tazobactam. KPN’s resistance rates to cephalosporins exceeded 50%. The resistance rate to cefoperazone-sulbactam decreased from 51.7% in 2018 to 12.2% in 2021 before increasing to 25.7% in 2022. The resistance rates to ceftolozane-tazobactam in the preceding 3 years ranged from 9.1–20.8%. The resistance rates to imipenem and meropenem have gradually decreased to 33.8% and 40.2% in 2022, respectively, whereas the resistance rate to ertapenem has increased from 14.8–35.2%. The resistance rate of KPN gradually declined from 41.6–25.7% for levofloxacin, while remained considerably high at 63.8% and 44.6% for moxifloxacin and ciprofloxacin, respectively. The resistance rate of KPN to amikacin declined from 29.1–9.1%. KPN exhibited the greatest vulnerability to polymyxin B, tigecycline, and polymyxin E, with resistance rates of 0.9%, 2.2% and 3.1%, correspondingly. Cross-resistance analysis revealed that no KPN strain was resistant to both polymyxin B and meropenem. However, varying degrees of meropenem co-resistance were observed with tigecycline (2%), imipenem (16%), amikacin (27%), colistin (37%) and levofloxacin (41%), respectively.
Conclusion
The clinical isolation rate of KPN was significantly elevated in PICU. Additionally, there was a substantial rise in drug resistance rates over a span of 7 years. Consequently, it is imperative to emphasize the prudent utilization of antibiotics in pediatric patients, implement efficient infection control measures, and employ suitable combinations of antibiotics to effectively tackle this urgent matter.
Continuous contact transfer behavior in bypass coupling triple-wire indirect arc welding
Authors: Liu Liming , Xu Guomin , Li Hao , Ba Xianli 
Published: January 2024

Abstract
Continuous contact transfer mode in bypass coupling triple-wire indirect arc welding (BCTW-GIA) is proposed to pursue an optional way to ensure the high deposition rate and obtain stable depositing process. The arc behaviors, droplet transfer and process stability with different distance between the tips (d1) of the main wire and side wires and the feeding speed of main wire (FSM) were studied. With the increase d1 and FSM, the droplet transfer mode of main wire varied from explosive transfer to short-circuit transfer to bridge transfer. When the d1 was greater than 4 mm, the continuous contact transfer bypass coupling triple-wire indirect arc welding can be realized and the welding process stability was improved. With the d1 adjusted from 0 mm to 6 mm, the standard deviation of the current dropped from 123.8 to 53.8 and its variation coefficient from 117.33–39.24% at FSM = 1 m/min. The weld penetration and weld width reduced with the FSM increasing, while the weld reinforcement gradually increased.
Aerobiological Study at the Uam-azcapotzalco, in Mexico City
Authors: Chávez-Sandoval Blanca Estela , Galindo-Pérez Ezel Jacome , Naranjo-Castañeda Félix Antonio , Klériga-Blanco Jorge David Iván , García-Franco Francisco 
Published: January 2024

Abstract
Aerobiological analyses allow us to evaluate air quality, if we live in a city like Mexico City, it is common to link it with industrial, commercial and vehicle use activities, among others, this fact is of such importance, since poor air quality can cause a wide variety of respiratory diseases depending on the time of exposure. The present work focused on carrying out an aerobiological study in six sites sampled at the UAM-Azcapotzalco. A total of 547 bacterial colonies and 297 fungal colonies were found. The maximum averages obtained for bacteria were in the dining room (22 UFC/m3) and the football field (48.75 CFU/m3), while for fungi the highest concentrations were recorded in the dining room (11.25 CFU/m3) and library (20.22 CFU/m3) areas. The Analysis of Variance showed that there are no significant differences for fungi and bacteria in the open and closed sites (p = 0.023), however the geospatial analysis helped to determine the areas with the highest density of microorganisms. The constant monitoring of bioaerosols, and the concentrations present in places with a high attendance of people, contributes to the generation of strategies to minimize the risks to human health, avoiding the generation of highly contagious diseases, such as the pandemic derived from SARS-CoV-2, among others. Finally, to minimize the microenvironmental conditions that allow the growth of microorganisms, we suggest the implementation of vegetal covers and natural surfaces inside and outside the work centers, as well as improvements in bio architecture, which would allow safe study and work.
Experimental and Numerical Study on the Model of Hybrid Fiber Phase Change Concrete Frozen Shaft Wall
Authors: Dongwei Li , Zhiwen Jia , Zecheng Wang , Kaixi Xue , Zhenhua Wang , Changtai Luo , Fang Fang 
Published: January 2024

Abstract
This article adds phase change materials to hybrid fiber concrete innovatively, utilizing the characteristics of phase change materials that can absorb (release) heat during the phase change process, actively responding to complex temperature environments and their changes, reducing the temperature difference inside the concrete, and thus preventing the occurrence of temperature cracks in deep wellbore structures. Through the temperature control model test of the frozen shaft wall, it can be seen that the hybrid fiber phase change concrete (HFPCC) significantly reduces the internal temperature difference, and the maximum temperature difference along the radial direction is 35.84% lower than that of benchmark concrete (BC). The numerical simulation results indicate that a moderate phase transition temperature should be selected in engineering. The phase change temperature should not be close to the ambient temperature and peak temperature. The peak temperature can be reduced by 9.32% and the maximum radial temperature difference can be reduced by 30.89% by selecting an appropriate phase change temperature. The peak temperature and radial maximum temperature difference are both proportional to the latent heat of phase change. The temperature control performance of phase change concrete can be further improved by increasing the latent heat of phase change materials.