bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abusive use of Zolpidem as a Result of COVID-19 and Perspectives of
Continuity of the Problem in the Post-Pandemic Period
Authors: de Lima Wesley Dawison , da Silva Michael Douglas , de Souza Costa Eurico , Pinheiro Francisco Irochima , de Azevedo Eduardo Pereira , Cobucci Ricardo Ney , de Paiva Cavalcanti José Rodolfo Lopes , Guzen Fausto Pierdoná 
Published: October 2023

Abstract:
Zolpidem is a non-benzodiazepine hypnotic drug that works as a positive modulator of
Gamma-Amino Butyric Acid-A (GABA-A) receptors, with high selectivity for α1 subunits. Given this
selective binding, the drug has a strong hypnotic activity. Social isolation during the SARS-CoV-2
pandemic has contributed to increased rates of anxiety, depression, and insomnia. As a result, studies
have pointed to a possible increase in the indiscriminate use of drugs with sedative effects, such as
Zolpidem, during the pandemic. The aim of this work was to present prospective evidence that warns
of the possibility of the abusive use of Zolpidem even after the pandemic. High rates of addiction to
this drug have been reported around the world after the emergence of the coronavirus. Data from the
National Survey on Drug Use and Health and from Medicaid support the continuing growth in prescription
and indiscriminate use of Zolpidem during the pandemic and afterward. Therefore, there is
enough evidence to support the indiscriminate use of this drug since the beginning of the pandemic.
Rates of indiscriminate use of sedatives may continue to increase in the post-pandemic period, especially
if strict control measures are not taken by health authorities.
Critical review of the utilization of Panchagavya in the form of Nutraceuticals
Authors: Vasavi Totawar (Madurwar)  
Published: October 2023

Background: In India Cow represents Mother Earth and is commonly called as ‘Gaumata’ because of its nourishing nature. In Ayurveda, since ancient time’s cow products have been used for a healthy body, therapeutic purposes and pharmaceutical processes. Panchagavya is a mixture prepared by using five ingredients derived from Cow. The three direct ingredients are cow dung, cow urine and cow milk and the two derived products are ghee and curd each of which represents ‘Gavya’ i.e., obtained from Gou (Cow). Each Gavya can be used individually or in combination with other products. Any product generated from food sources having additional health advantages in addition to the essential nutritional content contained in foods is considered as a Nutraceutical. The long standing consumer acceptability of nutraceuticals is brought about by their association with conventional medicine. Although the idea of nutraceuticals has grown in popularity recently, it has its roots in the traditional Ayurvedic medicine of ancient India. Aims and Objectives: This work is a modest attempt to employ Panchagavya as a kind of nutraceutical. Materials and Methods: Various books and review articles were referred to carry out this review. Results and Conclusion: A number of illness, including obesity, dietary and gastrointestinal tract abnormalities, leucoderma, wound healing, leucorrhoea, hepatitis, TB, ulcer, chemical intoxication, as well as other bacterial, fungal and viral infections, are advised for Panchgavya therapy. Nutraceuticals are substances that have physiological benefits or provide protection against chronic diseases. Using this concept, Panchgavya can be used as a kind of nutraceutical.
miR-30c-2-3p suppresses the proliferation of human renal cell carcinoma cells by targeting TOP2A
Authors: Huang Xiaoyong , Jia Yuna , Shi Haiyan , Fan Haiyan , Sun Lingbo , Zhang Huahua , Wang Yanfeng , Chen Jie , Han Jiaqi , Wang Mingming , Du Juan , Zhang Jing 
Published: October 2023

Abstract

Background
The ambiguity of renal cell carcinoma (RCC) symptoms hinders early diagnosis, thereby contributing to high mortality rates. By attaching to the 3′-untranslated region (UTR) of the target gene, microRNAs (miRNAs) exert significant control over the expression of genes.

Objectives
To investigate the influence of miR-30c-2-3p and DNA topoisomerase II alpha (TOP2A) on RCC growth and the mechanisms underlying the regulation of its expression.

Methods
The expression of miRNA-30c-2-3p and TOP2A in RCC cells was examined using quantitative real-time polymerase chain reaction (qRT-PCR). MiR-30c-2-3p mimics, its inhibitors, and controls, as well as TOP2A short hairpin RNA (shRNA) and controls, were used to transfect the human RCC cell lines 786-O, Caki-1, and ACHN. Additionally, the roles of miRNA-30c-2-3p and TOP2A in the growth of RCC were evaluated using the cell counting kit (CCK)-8 test, colony formation assay, apoptosis analysis, and Western blotting. Meanwhile, binding of miRNA-30c-2-3p and TOP2A was verified using dual-luciferase reporter assays and Western blotting.

Results
miR-30c-2-p is underexpressed in RCC cells. Overexpression of miR-30c-2-p promotes apoptosis and inhibits proliferation of ACHN, Caki-1, and 786-O cells. miR-30c-2-3p targets TOP2A, which is elevated in RCC tissues and cells, whereas TOP2A silencing inhibits the proliferation ability of RCC cells. The miRNA-30c-2-3p inhibitor compromises TOP2A shRNA-induced apoptosis of RCC. RCC cells cotransfected with miRNA-30c-2-3p inhibitors and TOP2A shRNAs have a higher proliferation rate than those transfected with only TOP2A shRNAs.

Conclusions
Collectively, our results verify that miRNA-30c-2-3p has a tumor suppressor property. miRNA-30c-2-3p inhibits the proliferation of RCC through regulation of TOP2A. The data provide a viable therapeutic target for RCC.
Spatial assessment of nighttime anthropization in the Comoé National Park in Côte d’Ivoira (West Africa)
Authors: Sylla Gaoussou , Coulibaly Talnan Jean Honoré , Coulibaly Naga , Kouadio Koffi Claude Alain , Coulibaly Houebagnon Saint Jean Patrick , Cissé Souleymane , Sie Kambiré 
Published: October 2023

Abstract
Protected areas play a crucial role in preserving biological diversity, providing ecosystem services, and regulating hydroclimatic processes. However, the environmental balance of these areas is increasingly under threat due to rapid population growth, high demand for natural resources, and the effects of global warming. To address this, sustainable management of protected areas is essential. This study aims to develop a methodology for monitoring and assessing levels of nocturnal anthropogenic aggression in the Comoé National Park (CNP) in Côte d’Ivoire. By using geospatial data from the Day/Night Band of the Visible Infrared Imaging Radiometer Suite (VIIRS/DNB), the study characterizes the nocturnal anthropization of CNP through the use of several indices. First, light reflectance density is used to identify nighttime light emission foci. Second, the lighted area density index (LADI) is employed to understand the nature of nocturnal activities taking place within CNP, as indicated by artificial light at night (ALAN). Finally, the light intensity index (LII) is used to evaluate the degree of influence of nocturnal anthropogenic activities on biodiversity. The study also found important activities through LADI and observed a high level of light pollution in CNP. Ultimately, the findings of this study indicate that there is a significant level of nocturnal anthropization within CNP, highlighting the need for effective management and conservation efforts in the area.
PENYULUHAN MENGENAI KEBERLANJUTAN USAHA PERIKANAN TANGKAP SKALA KECIL BERDASARKAN ASPEK EKONOMI DI OHOI OHOIDERTAWUN KABUPATEN MALUKU TENGGARA
Authors: Picaulima S.M. , Notanubun J. , Kilmanun A.D. 
Published: October 2023

Pengabdian kepada masyarakat yang dilakukan di Ohoi Ohoidertawun ini bertujuan untuk memberikan pemahaman terkait keberlanjutan usaha perikanan skala kecil berdasarkan status kelayakan ekonomi yang meliputi aspek finansiaal usaha dan investasi modal usaha, agar usaha perikanan skala kecil kedepan dapat berjalan dengan baik dan menguntungkan. Metode pengabdian adalah penyuluhan yang meliputi diskusi dan tanya jawab. Hasil yang diperoleh menunjukan bahwa penyuluhan yang dilakukan berhasil dengan baik. Peserta mitra nelayan kecil dan staf Pemerintahan Ohoi Ohoidertawun sangat antusias dalam mengikuti penyampaian materi penyuluhan yang disampaikan oleh tim pengabdi sehingga ketika diakukan evaluasi pada akhir kegiatan pertanyaan mampu dijawab oleh peserta dengan baik dan benar. Masalah yang dihadapi oleh nelayan mitra adalah pendapatan usaha mitra nelayan kecil sangat tergantung pada musim penangkapan sehingga usaha perikanan tangkap skala kecil dimasa depan sulit diprediksi. Status kelayakan usaha perikanan meliputi kelayakan finansial usaha dan kelayakan investasi usaha. Kegiatan ini berjalan dengan baik, lancar dan penuh interaksi yang baik antara tim pengabdi dan peserta, hasil dari kegiatan ini telah meningkatkan pemahaman mitra nelayan kecil mengenai keberlanjutan usaha perikanan tangkap skala kecil di Ohoi Ohoidertawun.
Kata kunci : Keberlanjutan, Nelayan kecil, Kelayakan usaha, Finansial usaha, Investasi usaha.
PENINGKATAN PRODUKSI JAMUR TIRAM DENGAN APLIKASI TEKNOLOGI TEPAT GUNA
Authors: Atmika I.K.A. , Suriadi I.G.A.K. , Budiana I.M.D. , Arda I.G. 
Published: October 2023

UD Ayu Dewata Jamur adalah usaha pembudidaya jamur atau pembesaran messelium jamur tiram yang berlokasi di banjar Tegehe desa Batubulan-Gianyar. Produksi jamur tiram dikemas sederhana dengan kantong plastik ukuran 1 kg. Mitra pengabdian ini mempunyai permasalahan yang berkaitan dengan effisiensi dan produktifitas yang disebabkan oleh belum adanya sistem atau mekanisasi mempertahankan temperatur dan kelembaban ruang inkubasi messelium. Pengelola budi daya jamur tiram ini belum mempunyai ketrampilan maupun latar belakang pendidikan yang masih rendah. Tujuan dan luaran dari kegiatan ini adalah menghasilkan mekanisasi proses pengatur suhu dan kelembaban ruangan pembesaran messelium, yang dilengkapi dengan spray air atau kabut secara semi otomotis. Disamping itu tim juga memberikan pengetahuan tentang manajemen, keselamatan kerja dan pengendalian kualitas produk dalam kaitannya dengan penerapan mekanisasi ini. Metode yang ditawarkan pada program ini adalah merancang dan memasang mekanisasi spray semi otomatis yang dilengkapi juga dengan indikator temperatur dan kelembaban udara. Kegiatan di mitra dilaksanakan tanggal 25 Agustus 2019, 30 Agustus 2019, dan 2 September 2019 bertempat budidaya jamur tiram UD Ayu Dewata Jamur di desa Batubulan kecamatan Sukawati Gianyar-Bali. Kegiatan awal dimulai dengan membersihkan dan menyiapkan tempat pemasangan instalasi mekanisasi spray air atau kabut. Berikutnya adalah pemasangan dan uji coba sistem spraying air atau kabut. Kegiatan pemantauan dilakukan tanggal 2 Oktober 2019, dan didapat jamur tiram tumbuh dengan sangat baik.
Kata kunci : messelium, jamur tiram, mekanisasi, indikator temperatur, semi otomatis
SCREENING KELUHAN MUSKULOSKELETAL, PELAYANAN KESEHATAN FISIOTERAPI, PELATIHAN STRETCHING DAN SOSIALISASI FAKTOR RISIKO LOW BACK PAIN DAN POSISI KERJA ERGONOMIS PADA PETANI
Authors: Saraswati P.A.S. , Antari N.K.A.J. , Wibawa A. , Thanaya S.A. , Nugraha M.H.S. 
Published: October 2023

Penyakit akibat kerja (PAK) merupakan penyakit yang mempunyai penyebab yang spesifik atau memiliki hubungan yang kuat dengan pekerjaan, alat kerja, bahan, proses maupun lingkungan kerja. Berdasarkan analisis situasi, maka program yang diprioritaskan adalah membantu petani untuk dapat bekerja dengan risiko penyakit muskuloskeletal akibat kerja seminimal mungkin sehingga tidak mengganggu produktivitas dan menyebabkan disabilitas. Program yang diprioritaskan meliputi: screening keluhan muskuloskletal, pelatihan stretching masal, dan pelayanan fisioterapi, serta edukasi mengenai tata laksanan nyeri yang dapat dilakukan petani di rumah secara mandiri. Berdasarkan hasil pengabdian, terlihat bahwa rerata umur petani subak adalah 56 tahun dengan total lama kerja mencapai 16,5 tahun. Sementara dari segi nilai nordic body map, didapatkan rerata 30,6 dan masuk ke dalam kategori risiko rendah mengalami gangguan musculoskeletal. Kegiatan pengabdian ini berlangsung dengan baik dimana peserta memahami mengenai risiko gangguan musculoskeletal dan bagaimana teknik melakukan peregangan. Selain itu, telah terlaksana pula pelayanan fisioterapi berupa pemberian intervensi diberikan kepada petani yang mengalami nyeri punggung bawah, nyeri leher, tennis elbow, spasme otot di betis dan lengan. Pemberian intervensi fisioterapi dilakukan dengan memberikan elektroterapi, pendekatan manual terapi seperti massage, serta terapi latihan. Di akhir sesi, tim pengabdian juga melakukan edukasi mengenai tata laksana nyeri yang dapat dilakukan petani di rumah secara mandiri, serta sosialisasi mengenai low back pain dan posisi kerja yang ergonomis.
Kata kunci : ergonomis, muskuloskeletal, stretching, fisoterapi, petani
SOSIALISASI HUKUM BAGI MASYARAKAT MENGENAI PEMENUHAN KEWAJIBAN KREDIT SELAMA MASA PANDEMI COVID-19
Authors: D.Y. Utami P. , G.P. Yustiawan D. , A.S. Utari A. , T.L. Hadjon E. 
Published: October 2023

Selama masa pandemi COVID-19, terdapat permasalahan hukum yang dialami masyarakat mengenai ketidaktahuan akan adanya program restrukturisasi kredit dari pemerintah guna menangani kredit bermasalah serta kurangnya pemahaman mengenai sifat force majeure relative dari pandemi COVID-19 yang tidak menghapuskan kewajiban kredit, melainkan hanya bersifat menangguhkan melalui keringanan-keringanan pada upaya restrukturisasi kredit. Kegiatan berlokasi di Desa Satra, Kabupaten Klungkung. Tujuan dari kegiatan pengabdian kepada masyarakat ini ialah untuk memberikan pemahaman bagi masyarakat Desa Satra yang memiliki kredit bermasalah selama masa pandemi COVID-19 agar tetap berusaha dalam menjalankan pembayaran kewajiban kredit pada lembaga perbankan. Mengingat terjadinya pandemi COVID-19 sangat mempengaruhi tingkat perekonomian masyarakat, kegiatan ini juga bertujuan untuk memberikan pemahaman kepada masyarakat Desa Satra bahwa selama masa pandemi COVID-19 pihak perbankan tidak akan serta merta melakukan eksekusi terhadap benda jaminan ketika terjadi kredit bermasalah, melainkan masyarakat dapat diberikan keringanan pembayaran melalui upaya restrukturisasi kredit. Pelaksanaan kegiatan pengabdian dilakukan dengan memberikan sosialisasi, diskusi serta tanya jawab dengan mendalam sehingga sasaran kegiatan pengabdian dapat tercapai dengan sangat baik. Hasil kegiatan ini menunjukkan bahwa kegiatan sangat efektif dilakukan, yang terbukti dari antusiasnya responden yang merupakan masyarakat umum, pengurus desa dan pengurus BUMDES di Desa Satra dalam menyimak pemaparan tim pengabdi.
Kata Kunci : Sosialisasi Hukum, Kredit Macet, Restrukturisasi, COVID-19.
A Comparative Study of Indonesian and Japanese Classifiers
Authors: Astariani Sandra 
Published: October 2023

Abstract
Classifiers belong to open class noun. All languages are naturally occupied with classifiers, yet the usage is various depending on how the language treats them. Japanese language, as an obligatory-classifier language, makes the classifiers compulsory, in contrast with an optional-classifier language, Indonesian language. Despite this, Japanese and Indonesian languages treat the classifiers syntactically and semantically similar. This article aims at revealing, both the semantic and syntactic differences and similarities between Japanese and Indonesian classifiers. The analysis shows that in terms of structure, Japanese and Indonesian classifiers are similar; however, each language demonstrates difference in classifier use. Japanese language has nineteen frequently used classifiers including two types which can replace others. They can change their form by fusing with its numeral adjective as in hitori (ichi-nin), ippiki (ichi-hiki), without affecting the whole meaning of the noun phrase. Indonesian classifiers cover of twenty-two optional types. Classifiers are often omitted in spoken form to avoid formality and some of them can also change their form by adding se- prior to the numeral adjective to indicate “one object” as in sebatang rokok.
RAZVOJ APLIKACIJE ZA REŠAVANJE PROBLEMA MANUELNOG RAČUNANjA POTROŠNjE VAZDUHA POD PRITISKOM
Authors: Lazić Dejan 
Published: October 2023

U ovom radu je predstavljen proces razvoja aplikacije pomoću kojeg se automatski obrađuju podaci dobijeni sa mernog uređaja „AirBox“. Automatskim računanjem ukupne potrošnju vazduha pod pritiskom u izabranom intervalu vremena rešen je problem dosadašnjeg, manulenog načina računanja ukupne potrošnje vazduha pod pritiskom. Podaci sa mernog uređaja „AirBox“, koji se koristio za potrebe ovog rada, se konvertuju u CSV tip fajla i uvoze u razvijenu aplikaciju. Izvršena je validacija dobijenih rezultata.
MOGUĆNOST PRIMENE EKSERGETSKE ANALIZE U ENERGETICI
Authors: Hovanec Luka , Stepanov Borivoj 
Published: October 2023

Cilj rada je da se analizira koncept eksergije, daju osnove pojma eksergije i eksergetske analize, i prikažu primeri eksergetske analize. U prvom delu rada dati su osnovni pojmovi koji su potrebni za razumevanje eksergije. Kao što su: nepovratnosti, fizička i hemijska eksergija, okolina itd. Primer eksergetske analize dat je za parno-turbinsko i gasno-turbinsko postrojenje. Kotao je najveći izvor eksergetskih gubitaka, njegova eksergijska efikasnost je samo = 0,4306. Najveći izvor nepovratnosti odnosno gubitaka eksergije u gasno-turbinskom postrojenju jeste komora za sagorevanje. Cilj ovoga jeste dati dobar uvid u to kako se eksergetska analiza izvodi kao i izdvojiti najbitnije zaključke i time unaprediti shvatanje značaja eksergetske analize.
The Regulation of Legal Responsibility: Illegal Logging Perpetrators in Indonesia and Nigeria
Authors: Akhmaddhian Suwari , Okolie Ugo Chuks , Hidayat Sarip , Andriyani Yani , Tiaranita Intan 
Published: October 2023

The study aims to analyze the offenders of illegal logging in Indonesia and Nigeria from its legal liability regulations. The study employed an socio-legal approach involving literary analyses on legal materials used─the statutory regulations, scientific journals and other pertinent documents. The results shows that legal responsibility for illegal logging perpetrators in Indonesia are under the Law on Forestry, the Law on Prevention and Eradication of Forest Destruction, and the Law on Cipta Kerja. In Nigeria, it is governed by several states, such as the Edo State Forestry (Amendment) Law 2002; Cross River State Forestry Commission Law 2010; and Taraba State Forestry Law 2010. Finally, the legal responsibility for illegal logging has been established in both countries. Accordingly, the indonesian government is suggested to disseminate the latest laws and regulations, so that the public and corporations are aware of them. Meanwhile, Nigerian government is expected to immediately issue nationwide legislation on illegal logging, so that law enforcement is not relied solely on the requirements of each state
Legal Responsibility for Environmental Damage Caused by Russian and Ukrainan Wars: International Humanitarian and Criminal Law Perspectives
Authors: Romdoni Rafi Nasrulloh Muhammad 
Published: October 2023

Not only inflicted human casualities, the war between Russia and Ukraine, also injured the environment. Russia's discriminating attacks on essential objects such as gas, energy, oil, and mining infrastructure become the most significant root cause. UNEP affirmed that the attacks resulted in widespread water, soil and air pollution, as well as a significant deterioration in Ukraine's ecosystem stability. Accordingly, the study intends to examine the framework of international humanitarian and criminal law, specifically in terms of enviromental protection, as well as to analyze accountability before the International Criminal Court. The study employed doctrinal method involving a statutory and conceptual approach. In this case, relevant legal instruments such as the 1949 Geneva Conventions and their Additional Protocols, as well as the Rome Statute, were being examined. Furthermore, the study is also certified by the evolution of legal doctrines in books, jounals, and other credible sources. According to the findings, humanitarian law, which is underpinned by customary international law, protects the environment slightly better than international criminal law. In short, the state bears multiple duties for environmental damage caused by the outbreak of war. Individual accountability before the ICC, on the other hand, is being overlooked. It is due to the Rome Statute's flaws, which include vagueness in the formulation of the articles, stringent standards for proof of environmental damage, and bias in proving mens rea. As a result, improvements in the enforcement of international crimes (war crimes and related types) that cause environmental damage are urgently required
Using of neural networks to search for errors of patient's positioning on chest X-rays
Authors: Васильев Юрий Александрович , Владзимирский Антон Вячеславович , Омелянская Ольга Васильевна , Семенов Серафим Сергеевич , Арзамасов Кирилл Михайлович , Борисов Александр Александрович 
Published: October 2023

В работе представлены результаты применения трансферного обучения
глубоких сверточных нейронных сетей для задачи поиска рентгенограмм
органов грудной клетки с нарушениями укладки и позиционирования
пациента. Оцениваемые нейросетевые архитектуры: InceptionV3, Xception,
ResNet152V2, InceptionResNetV2, DenseNet201, VGG16, VGG19, MobileNetV2,
NASNetLarge. Для обучения и тестирования использовались рентгенограммы
грудной клетки, полученные из открытых наборов данных и Единого
радиологического информационного сервиса города Москвы. Все полученные
модели имели метрики диагностической точности выше 95%, при этом модели
на основе архитектур ResNet152V2, DenseNet201, VGG16, MobileNetV2 имели
статистически значимо лучшие метрики, чем другие модели. Наилучшие
абсолютные значения метрик показала модель ResNet152V2 (AUC =0.999
,чувствительность=0.987, специфичность=0.988, общая валидность =0.988,
F1 мера = 0.988). Модель MobileNetV2 показала наилучшую скорость
обработки одного исследования
(67.8±5.0
ms). Широкое использование полученных нами алгоритмов способно облегчить
создание больших баз данных качественных медицинских изображений, а
также оптимизировать контроль качества при выполнении
рентгенографических исследований органов грудной клетки.
Cytomorphology of mesenchymal lesions in a tertiary care centre and its correlation with histopathology
Authors: Shahab Juhi , Maheshwari Rashi , Singh Mukul , Sharma Rohit , Ahluwalia Charanjeet , Zaheer Sufian , Ahuja Sana 
Published: October 2023

Objectives:
Fine needle aspiration cytology (FNAC) is a minimally invasive method for sampling a heterogenous lesion. It is one of the first-line investigations in the evaluation of soft tissue tumours. However, the heterogeneity of mesenchymal lesions pose a challenge to the cytological diagnosis. The present study aims at evaluation of the cytomorphological findings of mesenchymal lesions on FNAC along with their histopathological correlation.

Material and Methods:
This was a retrospective study conducted over a period of 1 year from January 2021 to January 2022. All the patients of cytologically diagnosed mesenchymal lesions on their FNA aspirates were included in the study. Cytomorphology of the May Grunwald Giemsa and Papanicolaou stained slides were examined and correlated with clinical and histopathological details wherever available.

Results:
Out of the 90 patients, 69 (76.7%) were males and 21 (23.3%) were females. Maximum number of cases were in 4–5th decade of life. The lower limb was found to be the most common site (57.8%) for the mesenchymal lesions. Majority of the cases on FNA in our study were found to be benign – 79 (87.8%), while only 11 cases were malignant (12.2%). On cytological examination, spindle cell lesions were most common followed by adipocytic lesions. Based on the cyto-histological correlation, sensitivity, specificity, negative predictive value, positive predictive value and diagnostic accuracy of FNAC in diagnosis of mesenchymal lesion was 78.6%, 100%, 92.5%, 100% and 94.1% respectively.

Conclusion:
FNAC is a simple and minimally invasive tool that plays an important role in triaging patients with good specificity and sensitivity.