bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventive effects of caffeine on nicotine plus high-fat diet-induced hepatic steatosis and gain weight: a possible explanation for why obese smokers with high coffee consumption tend to be leaner
Authors: Lu Naiyan , Mei Xue , Li Xu , Tang Xue , Yang Guofeng , Xiang Wen 
Published: December 2023

AbstractNon-alcoholic fatty liver disease (NAFLD) is a prevalent liver disorder, affecting approximately 25 % of the population. Coffee-drinking obese smokers exhibit lower body weights and decreased NAFLD rates, but the reasons behind this remain unclear. Additionally, the effect of nicotine, the main component of tobacco, on the development of NAFLD is still controversial. Our study aimed to explore the possible reasons that drinking coffee could alleviate NAFLD and gain weight and identify the real role of nicotine in NAFLD of obese smokers. A NAFLD model in mice was induced by administering nicotine and a high-fat diet (HFD). We recorded changes in body weight and daily food intake, measured the weights of the liver and visceral fat, and observed liver and adipose tissue histopathology. Lipid levels, liver function, liver malondialdehyde (MDA), superoxide dismutase (SOD), serum inflammatory cytokine levels and the expression of hepatic genes involved in lipid metabolism were determined. Our results demonstrated that nicotine exacerbated the development of NAFLD and caffeine had a hepatoprotective effect on NAFLD. The administration of caffeine could ameliorate nicotine-plus-HFD-induced NAFLD by reducing lipid accumulation, regulating hepatic lipid metabolism, alleviating oxidative stress, attenuating inflammatory response and restoring hepatic functions. These results might explain why obese smokers with high coffee consumption exhibit the lower incidence rate of NAFLD and tend to be leaner. It is essential to emphasise that the detrimental impact of smoking on health is multifaceted. Smoking cessation remains the sole practical and effective strategy for averting the tobacco-related complications and reducing the risk of mortality.
Oswaldocruzia franciscoensis n. sp. (Nematoda: Molineidae) in Leptodactylus macrosternum Miranda-Ribeiro, 1926 (Anura: Leptodactylidae) from Caatinga morphoclimatic domain, Brazil: morphological and molecular characterisation
Authors: Vieira F.M. , Pereira F.B. , Ribeiro L.B. , Oliveira J.B. , Silva D.C.N. , Muniz-Pereira L.C. , Felix-Nascimento G. 
Published: December 2023

Abstract
A new species of Oswaldocruzia Travassos, 1917 (Nematoda, Molineidae), parasite of Leptodactylus macrosternum Miranda-Ribeiro, 1926 (Anura: Leptodactylidae), from Caatinga morphoclimatic domain, Brazil, is described based on morphological and molecular data. Oswaldocruzia franciscoensis n. sp. is characterised by an anterior extremity with a cephalic vesicle divided into two portions, a body covered by cuticular longitudinal ridges, and cervical alae. Males of the new species have caudal bursa of type I with a 2-1-2 pattern, spicules divided into a shoe, bifurcated fork, and blade with two unequal branches, in which the longer branch bifurcates at its distal portion end and the smaller branch with three distal processes, each with distal bifurcations. Females have didelphic and amphidelphic uteri, an ovijector divided into vestibule, anterior and posterior sphincters, and anterior and posterior infundibula. The new species differs from its Neotropical congeners that have caudal bursa of type I, based on the presence of cervical alae and by having a spicular blade distally divided into two unequal branches, with the longer branch bifurcating at its distal portion and smaller branch with three distal processes, each distally bifurcated. The partial 18S rDNA sequence generated for Oswaldocruzia franciscoensis n. sp. is the first of a representative belonging to this genus in the Neotropical region.
The view from Manywhere: normative economics with context-dependent preferences
Authors: Lecouteux Guilhem , Mitrouchev Ivan 
Published: December 2023

AbstractWe propose a methodology for normative evaluation when preferences are context-dependent. We offer a precise definition of context-dependence and formulate a normative criterion of self-determination, according to which one situation is better than another if individuals are aware of more potential contexts of a choice problem. We provide two interpretations of our normative approach: an extension of Sugden’s opportunity criterion and an application of Sen’s positional views in his theory of justice. Our proposition is consistent with Muldoon’s and Gaus’ approaches of public reason in social contract theory, which account for the diversity of perspectives in non-ideal worlds.
Passive acoustic monitoring detects new records of globally threatened birds in a high-elevation wetland (Free State, South Africa)
Authors: Mosikidi Toka , Le Maitre Nicholas , Steenhuisen Sandy-Lynn , Clark Vincent Ralph , Lloyd Kyle Smith , Le Roux Aliza 
Published: December 2023

Summary
Wetlands act as islands of high biodiversity within the ecological landscape and provide crucial ecosystem services to society. Anthropogenic activities are driving wetland degradation and it has become increasingly rare to find wetlands that do not show signs of biodiversity loss or alteration. The exacerbated loss of biodiversity in wetlands has a negative impact on the local economy and ecosystem services provided by these systems. We responded to the South African National Biodiversity Assessment (NBA) call to document wetland biodiversity against the backdrop of sustained wetland degradation in southern Africa. We monitored the soundscape of a high-elevation wetland in the Golden Gate Highlands National Park (GGHNP) from June 2019 to December 2020 across 24 localities using a rolling grid layout. We detected 35.9% of the avian species previously recorded from ad hoc sightings in the GGHNP of which 68.1% are wetland obligate species. We contributed an additional 10.2% new species records to the avian diversity of the GGHNP, including 24 species that are considered threatened by the International Union for Conservation of Nature (IUCN). Our remote monitoring technique enabled the first ever continuous monitoring using remote acoustic equipment for a high-elevation wetland in South Africa, thus providing a valuable contribution to the NBA call.
Development and evaluation of food preservation lessons for gardeners: application of the DESIGN process
Authors: Beavers Alyssa W , Kennedy Allison O , Blake Jessica P , Comstock Sarah S 
Published: December 2023

Abstract

Objective:
This study presents the development and evaluation of food preservation lessons for gardeners.

Design:
Lessons were developed using the DESIGN process, a nutrition education program planning framework. This study examines the effectiveness of this curriculum at increasing knowledge of proper food preservation practices and increasing participants’ confidence in home food preservation, identifies challenges participants experienced with home food preservation and assesses the perceived influence of home food preservation on vegetable intake and aspects of food security. We used the DESIGN process developed by Contento and Koch to develop the curricula and used social cognitive theory to guide the lesson development. Lessons on three types of food preservation (freezing, water bath canning and pressure canning) were developed and presented to adult gardeners. The evaluation consisted of post-lesson surveys and a follow-up survey several months after the lessons.

Setting:
Mid-Michigan, USA.

Participants:
Adult gardeners.

Results:
Food preservation confidence increased following the lessons. At follow-up, 64 % of participants agreed or strongly agreed that they ate more fruit and vegetables because of preserving food, 57 % of respondents agreed or strongly agreed that they spend less money on food due to preserving, while 71 % reported being better able to provide food for themselves and their family. Lastly, 93 % reported feeling better about where their food comes from and wasting less food due to preserving.

Conclusions:
This study provides evidence that home food preservation may be beneficial in promoting fruit and vegetable intake and food security among gardeners.
Geodynamic Controls on Basaltic Volcanism in the Arabian Peninsula: Evolution of Harrat Uwayrid, Saudi Arabia
Authors: Bowden Shelby , Furman Tanya , Alhumimidi Mansour , Hames Willis , Assiri Ali , Alyousif Mazen , Almutairi Ramzi , Alqahtani Hamad , Rogaib Abdurahman Bin , Rushood Abdulaziz Bin , AlYousef Khaled 
Published: December 2023

AbstractBasaltic lavas from Harrat Uwayrid, Saudi Arabia, record the evolving magmatic and tectonic context of the Arabian Peninsula from at least the mid‐Miocene to the present day. New 40Ar/39Ar ages spanning from the mid to late Miocene reveal that mid‐Miocene mafic volcanism formed a large, subalkaline volcanic plateau parallel to Red Sea rifts. Subsequent volumetrically subordinate late Miocene‐Quaternary alkaline volcanism erupted monogenetic cinder cones roughly orthogonal to the earlier volcanic field. The source region for all samples was affected by both fluid and silicate metasomatism; inferred mantle mineral assemblages include amphibole for mid‐Miocene lavas and phlogopite for late Miocene‐Quaternary samples. Calculated melting depths become shallower with time across the Miocene volcanic episode (∼20–15 Ma) but become deeper in the late Miocene to Quaternary (∼10–0 Ma), indicating melting pressures and temperatures significantly higher than those recorded in Miocene lavas despite progressive lithospheric thinning. We offer a two‐stage model for the formation of Harrat Uwayrid: (a) Early‐ and mid‐Miocene rifting associated with the Red Sea opening facilitated adiabatic melting of uppermost mantle lithosphere to form the early volcanic plateau and (b) Plate motion changes in the mid‐ and late‐Miocene initiated the Dead Sea Fault and destabilized a dense pyroxenitic lower lithosphere leading to foundering or lithospheric drip beneath Harrat Uwayrid that allowed deep lithospheric melting and formed the young volatile‐rich eruptives.
PickBlue: Seismic Phase Picking for Ocean Bottom Seismometers With Deep Learning
Authors: Bornstein T. , Lange D. , Münchmeyer J. , Woollam J. , Rietbrock A. , Barcheck G. , Grevemeyer I. , Tilmann F. 
Published: December 2023

AbstractDetecting phase arrivals and pinpointing the arrival times of seismic phases in seismograms is crucial for many seismological analysis workflows. For land station data, machine learning methods have already found widespread adoption. However, deep learning approaches are not yet commonly applied to ocean bottom data due to a lack of appropriate training data and models. Here, we compiled an extensive and labeled ocean bottom seismometer (OBS) data set from 15 deployments in different tectonic settings, comprising ∼90,000 P and ∼63,000 S manual picks from 13,190 events and 355 stations. We propose PickBlue, an adaptation of the two popular deep learning networks EQTransformer and PhaseNet. PickBlue joint processes three seismometer recordings in conjunction with a hydrophone component and is trained with the waveforms in the new database. The performance is enhanced by employing transfer learning, where initial weights are derived from models trained with land earthquake data. PickBlue significantly outperforms neural networks trained with land stations and models trained without hydrophone data. The model achieves a mean absolute deviation of 0.05 s for P‐waves and 0.12 s for S‐waves, and we apply the picker on the Hikurangi Ocean Bottom Tremor and Slow Slip OBS deployment offshore New Zealand. We integrate our data set and trained models into SeisBench to enable an easy and direct application in future deployments.
Compounding Uncertainties in Economic and Population Growth Increase Tail Risks for Relevant Outcomes Across Sectors
Authors: Kanyako Franklyn , Lamontagne Jonathan , Snyder Abigail , Morris Jennifer , Iyer Gokul , Dolan Flannery , Ou Yang , Cox Kenneth 
Published: December 2023

AbstractUnderstanding the long‐term effects of population and GDP changes requires a multisectoral and regional understanding of the coupled human‐Earth system, as the long‐term evolution of this coupled system is influenced by human decisions and the Earth system. This study investigates the impact of compounding economic and population growth uncertainties on long‐term multisectoral outcomes. We use the Global Change Analysis Model (GCAM) to explore the influence of compounding and feedback between future GDP and population growth on four key sectors: final energy consumption, water withdrawal, staple food prices, and CO2 emissions. The results show that uncertainties in GDP and population compound, resulting in a magnification of tail risks for outcomes across sectors and regions. Compounding uncertainties significantly impact metrics such as CO2 emissions and final energy consumption, particularly at the upper tail at both global and regional levels. However, the impact of staple food prices and water withdrawal depends on regional factors. Additionally, an alternative low‐carbon transition scenario could compound uncertainties and increase tail risk, particularly in staple food prices, highlighting the influence of emergent constraints on land availability and food‐energy competition for land use. The findings underscore the importance of considering and adequately accounting for compounding uncertainties in key drivers of multisectoral systems to enhance our comprehensive understanding of the complex nature of multisectoral systems. The paper provides valuable insights into the potential implications of compounding uncertainties.
High‐Latitude Geomagnetic Secular Variation at the End of the Cretaceous Normal Superchron Recorded by Volcanic Flows From the Okhotsk‐Chukotka Volcanic Belt
Authors: Lhuillier F. , Lebedev I. E. , Tikhomirov P. L. , Pavlov V. E. 
Published: December 2023

AbstractThe Cretaceous Normal Superchron (CNS, 84–121 Ma) is a singular period of the geodynamo's history, identified by a prolonged absence of polarity reversals. To better characterize the paleosecular variation (PSV) of the geomagnetic field at the end of this interval, we sampled seven continuous sequences of lava flows from the Okhotsk‐Chukotka Volcanic Belt, emplaced 84–89 Ma in the vicinity of the Kupol ore deposit (NE Russia). From a collection of 1,024 paleomagnetic cores out of 82 investigated lava flows, we successfully determined the paleodirections of 78 lava flows, which led to 57 directional groups after removing the serial correlations. The resulting paleomagnetic pole is located at 170.0°E, 76.8°N (A95 = 5.2°, N = 57), in good agreement with previous estimates for north‐eastern Eurasia. Aiming at quantifying PSV at a reconstructed paleolatitude (λ) of ∼80°N, we obtained a virtual geomagnetic pole (VGP) scatter , the value of which was corrected for within‐site dispersion and is little dependent on the choice of the selection criteria. Compared to previous paleodirectional data sets characterizing PSV at various paleolatitudes during the CNS, our Sb estimate confirms a relative latitudinal increase Sb(λ = 90°)/Sb(λ = 0°) on the order of 2–2.5. Focusing on PSV at high paleolatitude within the 70°–90° range, we show that Sb was ∼15% lower at the end of the CNS than during the past 10 Myr, confirming that the singular polarity regime of the geodynamo observed during the CNS is likely accompanied with reduced PSV.
Anthropogenic Carbon in the Arctic Ocean: Perspectives From Different Transient Tracers
Authors: Raimondi Lorenza , Wefing Anne‐Marie , Casacuberta Núria 
Published: December 2023

AbstractIn this study we investigated the physical characteristics of the Atlantic layer in the Arctic Ocean (AO) and its role in the distribution and storage of anthropogenic carbon (Cant). The novelty of this work is to use the Transit Time Distribution method (TTD) with the radionuclides 129I and 236U and its comparison to the commonly applied gas tracers, CFC‐12 and SF6. Overall, our examination of two distinct tracer pairs, along with the novel TTD method in comparison to a classical approach, revealed a notable agreement, highlighting the robustness of these Cant estimates. The TTD analysis based on radionuclides showed that whereas the Eurasian Basin has shorter transit times and is dominated by strong mixing conditions, the Amerasian Basin is characterized by longer transit times and a strong advective flow. Overall, the Cant concentrations obtained from radionuclides confirm that the distribution in the AO follows its circulation patterns, with higher concentrations in the Eurasian Basin (∼50 μmol kg−1) compared to the Amerasian one (∼36–42 μmol kg−1). An estimated partial inventory of 0.85 ± 0.17 and 1.0 ± 0.03 Pg C was assessed for 2015 from the novel application of TTD with radionuclides and gas tracers, respectively. Finally, we identified the saturation of gas tracers as a larger source of uncertainty for Cant estimation compared to the uncertainty associated to different radionuclides' input functions, thus remarking the importance of including non‐saturation dependent tracers, such as radionuclides, as an additional tool to support Cant estimates in the AO.
Plant-expressed Zika virus envelope protein elicited protective immunity against the Zika virus in immunocompetent mice
Authors: Shin Minna , Kang Hyangju , Shin Kyeong ryeol , Lee Rangyeon , Kim Kiju , Min Kyungmin , Cho Kyou-Nam , Sohn Eun-Ju , Kim Kwang Sung , Kim Seok-Hyun , Cho Yang Je , Park Jeongho , Hahn Tae-Wook 
Published: December 2023

AbstractZika virus infection causes multiple clinical issues, including Guillain–Barré syndrome and neonatal malformation. Vaccination is considered as the only strategy for the prevention of ZIKV-induced clinical issues. This study developed a plant-based recombinant vaccine that transiently expressed the ZIKV envelope protein (ZikaEnv:aghFc) in Nicotiana benthamiana and evaluated the protective immunity afforded by it in immunocompetent mice. ZikaEnv:aghFc induced both humoral and cellular immunity at a low dose (1–5 μg). This immune-inducing potential was enhanced further when adjuvanted CIA09A. In addition, antigen-specific antibodies and neutralizing antibodies were vertically transferred from immunized females to their progeny and afforded both protective immunity to ZIKV and cross-protection to Dengue virus infection. These results suggest that our plant-based ZIKV vaccine provides a safe and efficient protective strategy with a competitive edge.
A signal recognition particle receptor gene from the sea cucumber, Apostichopus japonicas
Authors: Zhang Jian , Sun Zhihui , Su Weiyi , Wang Zengdong , Meng Weihan , Chang Yaqing 
Published: December 2023

AbstractThe signal recognition particle (SRP) system delivers approximately 30% of the proteome to the endoplasmic reticulum (ER) membrane. SRP receptor alpha (SRα) binds to SRP for targeting nascent secreted proteins to the ER membrane in eukaryotic cells. In this study, the SRα homologous gene was identified in the sea cucumber, Apostichopus japonicus (AjSRα). AjSRα codes for 641 amino acids and has 54.94% identity with its mammalian homologs. Like mammalian SRα, it is expected to contain the SRP-alpha N domain, SRP54_N domain, and SRP54 domain. In addition, AjSRα is ubiquitously expressed in adult tissues and exhibits a sexually dimorphic expression pattern, with significantly higher expression in ovaries compared to testes. As a maternal factor, AjSRα can be continuously detected during embryonic development. Importantly, we first attempted to investigate its function by using lentiviral vectors for delivering SRα gene-specific shRNA, and we revealed that lentiviral vectors do not induce an upregulation of immune-related enzymes in sea cucumbers. However, compared to the dsRNA-based RNA interference (RNAi) method, lentivirus-mediated RNAi caused dynamic changes in gene expression at a later time. This study supplied the technical support for studying the functional mechanism of SRα in sea cucumbers.
Preparations of Silyl Anions
Authors: Rasappan Ramesh , Pulikkottil Feba T. , Balakrishnan Venkadesh , Chandrasekaran Revathi , Murugesan Vetrivelan 
Published: December 2023

AbstractThis review collates synthetic procedures for the synthesis of different silyl anions, which are valuable reagents for chemists, particularly in the field of organic synthesis and organometallic chemistry. This includes the preparation of silyl anions of lithium, sodium, potassium, rubidium, and cesium from group I metals and silyl anions of beryllium, magnesium, calcium, strontium, and barium from group II metals. Synthetic procedures for silyl anions of zirconium, hafnium, cadmium, and zinc are also covered. The synthesis of group XIII silyl anions of boron and aluminum is also highlighted.1	Introduction2	Silyl Anions of Group I Metals2.1	Silyllithium2.2	Silylsodium2.3	Silylpotassium2.4	Silylrubidium and Silylcesium3	Silyl Anions of Group II Metals3.1	Silylberyllium3.2	Silylmagnesium3.3	Silylcalcium, -strontium, and -barium4	Silyl Anions of Transition Metals4.1	Silylzirconium and -hafnium4.2	Silylcopper and -cuprates4.3	Silylzinc4.4	Disilylzinc4.5	Silylzincate4.6	Silylcadmium5	Silyl Pronucleophiles of Group XIII5.1	Silylboranes5.2	Silylaluminum6	Silyl Anions of Group XIV6.1	Disilane Synthesis7	Conclusions
Short Synthesis of Dopamine Agonist Rotigotine
Authors: Chandrasekhar Srivari , Shekhar Chandra , Karmakar Santanu , Mainkar Prathama S. 
Published: December 2023

AbstractA practical and short synthesis of FDA approved drug, Rotigotine, is achieved in two steps from 5-methoxy-2-tetralone, which in turn was synthesised by [4+2] cycloaddition of the in situ generated methoxyaryne from its precursor aryl triflate with benzyloxybutadiene or from 4-methoxyindanone via ring expansion using trimethylsilyldiazomethane.
Establishing Safe Surgical Parameters for Placement of C2 Pedicle Screws: A Retrospective Study
Authors: Tunç Bekir , Divanlıoğlu Denizhan , Günerhan Göksal , Işıtan Egemen , Çağıl Emin , Dalgıç Ali 
Published: December 2023

Abstract
Background The study aimed to evaluate the safety and feasibility of transpedicular instrumentation for the C2 vertebra and to establish the precise anatomical parameters and boundaries within which this procedure can be safely and effectively performed.
Methods This retrospective study analyzed 66 patients who underwent C2 transpedicular screw fixation. Preoperative and postoperative axial, sagittal, and coronal computed tomography (CT) scans were examined. Anatomical measurements were taken to determine the horizontal and vertical distances from the C2 pedicle projection to the vertebral foramen using CT images. Based on the anatomical location of the vertebral artery within the C2 vertebral foramen, the patients were divided into four subgroups using the horizontal pedicle width (HPW) and vertical pedicle width (VPW) of the C2 spine.
Results The average age of the patients included in the study was 46.48 years. The patient population comprised 32 (48.5%) males and 34 (51.5%) females. Based on the anatomical measurements, the distribution of C2 vertebra types was as follows: type 1 accounted for 68.9%, type 2 for 3.8%, type 3 for 16.7%, and type 4 for 10.6%. Significantly narrower pedicle widths were observed in types 2 and 4 compared to other vertebra types. Type 2 had the largest medial angle (MA), while type 4 had the narrowest MA. In terms of the sagittal plane, type 4 exhibited the widest MA and type 3 had the narrowest MA, but these differences were not statistically significant. Among the cases, 12 (18.1%) involved the vertebral foramen, with 1 case (8.3%) showing screw-related vertebral artery injury (0.75% of all screws). No vertebral artery injuries were observed with the other transpedicular screws.
Conclusion Preoperative anatomical measurements for patients undergoing transpedicular instrumentation on the C2 vertebra should include planning CT images on three planes: axial, sagittal, and coronal.