bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of clinicopathological and imaging features of HBV-negative and HBV-positive intrahepatic cholangiocarcinoma patients with different pathologic differentiation degrees
Authors: Huang Xiaoli , Yu Dan , Gu Xintao , Li Jiansun , Chen Jiaqi , Zou Yuanqiang , Liao Jinyuan 
Published: November 2023

AbstractHepatitis B is a risk factor for the development of intrahepatic cholangiocarcinoma. The prognosis of HBV-related ICC remains to be further investigated. To investigate the clinical, pathological and imaging features of intrahepatic cholangiocarcinoma of hepatitis B virus-positive and -negative patients. Data from January 31, 2012 to December 31, 2019 of 138 patients were retrospectively analyzed. The patients were divided into hepatitis B virus-positive group (group A[n = 66]) and virus-negative group (group B[n = 72]), and the patients were divided into groups according to pathological differentiation degree and tumor size. The differences in clinical, imaging characteristics and the progression-free survival between groups were analyzed. There were significant differences in gender, age, HBc antibody, CA125 and AFP, tumor distribution site, maximum diameter, plain scan density, inferior hepatic angle, peritumoral bile duct dilatation, vascular encasement invasion, intrahepatic bile duct dilatation and lymphadenopathy between the two groups (P < 0.05); There were statistical differences in signs of vascular encasement invasion between the two groups with well-to-moderately differentiated tumors (P < 0.05); there were statistical differences in tumor density uniformity, signs of vascular encasement invasion and lymphadenopathy between the two groups with poorly differentiated tumors (P < 0.05). Large groups A and B showed differences in tumor density uniformity, vascular encasement invasion, arterial phase, overall reinforcement pattern, peritumoral bile duct stones and biliary dilatation (P < 0.05). There was no statistical difference in postoperative PFS between the two groups (P > 0.05). The clinical and imaging features of ICC of hepatitis B virus-positive and -negative patients are different, and there is little difference in postoperative disease-free survival time.
Chia seeds and coenzyme Q10 alleviate iron overload induced hepatorenal toxicity in mice via iron chelation and oxidative stress modulation
Authors: Sadek Shimaa A. , Marzouk Mohamed , Mohamed Hanan R. H. , El-sallam Bassant F. Abd , Elfiky Abdo A. , Sayed Amany A. 
Published: November 2023

AbstractIron overload (IOL) can cause hepatorenal damage due to iron-mediated oxidative and mitochondrial damage. Remarkably, combining a natural iron chelator with an antioxidant can exert greater efficacy than monotherapy. Thus, the present study aimed to evaluate the efficacy of Chia and CoQ10 to chelate excess iron and prevent hepatorenal oxidative damage in IOL mice. Male Swiss albino mice (n = 49) were randomly assigned to seven groups: control, dietary Chia, CoQ10, IOL, IOL + Chia, IOL + CoQ10, and IOL + Chia + CoQ10. Computational chemistry indicates that the phytic acid found in the Chia seeds is stable, reactive, and able to bind to up to three iron ions (both Fe2+ and Fe3+). IOL induced a significant (P < 0.05) increase in serum iron, ferritin, transferrin, TIBC, TSI, RBCs, Hb, MCV, MCH, WBCs, AST, ALT, creatinine, and MDA. IOL causes a significant (P < 0.05) decrease in UIBC, platelets, and antioxidant molecules (GSH, SOD, CAT, and GR). Also, IOL elicits mitochondrial membrane change depolarization, and DNA fragmentation and suppresses mitochondrial DNA copies. Furthermore, substantial changes in hepatic and renal tissue, including hepatocellular necrosis and apoptosis, glomerular degeneration, glomerular basement membrane thickening, and tubular degeneration, were observed in the IOL group. Dietary Chia and CoQ10 induced significant (P < 0.05) amelioration in all the mentioned parameters. They can mostly repair the abnormal architecture of hepatic and renal tissues induced by IOL, as signified by normal sinusoids, normal central veins, and neither glomerular damage nor degenerated tubules. In conclusion, the combined treatment with Chia + CoQ10 exerts more pronounced efficacy than monotherapy in hepatorenal protection via chelating excess iron and improved cellular antioxidant status and hepatorenal mitochondrial function in IOL mice.
Low EGFL7 expression is associated with high lymph node spread and invasion of lymphatic vessels in colorectal cancer
Authors: de Oliveira Cristiane , Martins Sandra Fátima Fernandes , Gonçalves Paola Gyuliane , Limone Gabriel Augusto , Longatto-Filho Adhemar , Reis Rui Manuel , Bidinotto Lucas Tadeu 
Published: November 2023

AbstractStudies indicate EGFL7 as an important gene in controlling angiogenesis and cancer growth, including in colorectal cancer (CRC). Anti-EGFL7 agents are being explored, yet without promising results. Therefore, the role of EGFL7 in CRC carcinogenesis should be investigated. This study aimed to evaluate the prognostic value of EGFL7 expression in CRC and the signaling pathways influenced by this gene. EGFL7 expression was evaluated through immunohistochemistry in 463 patients diagnosed with CRC and further associated with clinicopathological data, angiogenesis markers and survival. In silico analyzes were performed with colon adenocarcinoma data from The Cancer Genome Atlas. Analysis of enriched gene ontology and pathways were performed using the differentially expressed genes. 77.7% of patients presented low EGFL7 expression, which was associated with higher lymph node spread and invasion of lymphatic vessels, with no impact on survival. Additionally, low EGFL7 expression was associated with high VEGFR2 expression. Finally, we found in silico that EGFL7 expression was associated with cell growth, angiogenesis, and important pathways such as VEGF, Rap-1, MAPK and PI3K/Akt. Expression of EGFL7 in tumor cells may be associated with important pathways that can alter functions related to tumor invasive processes, preventing recurrence and metastatic process.
Changes in sputum microbiota during treatment for nontuberculous mycobacterial pulmonary disease
Authors: Kim Bo-Guen , Yu Jin Young , Kim Su-Young , Kim Dae Hun , Jhun Byung Woo 
Published: November 2023

AbstractLimited data exist on longitudinal changes in the sputum bacterial microbiome during treatment in nontuberculous mycobacterial pulmonary disease (NTM-PD) patients. We prospectively collected serial sputum samples from 14 NTM-PD patients during treatment, at the start (n = 14) and at 1 (n = 10), 3 (n = 10), 6 (n = 12), and 12 (n = 7) months. The bacterial microbiome changes were analyzed using 16S rRNA sequences (V3–V4 regions). Subgroup analysis included culture conversion (n = 9) and treatment refractory (n = 5) groups. In all patients, sputum alpha-diversity (ACE, Chao1, and Jackknife) significantly decreased during antibiotic treatment at 1, 3, 6, and 12 months compared to treatment initiation levels. Within the culture conversion group, genus/species-level beta-diversity showed differences at 1, 3, 6, and 12 months compared to treatment initiation (all p < 0.05). However, in the refractory group, there were no differences in beta-diversity at the genus/species levels in the sputum at any time point. In the linear discriminant analysis (LDA) effect sizes (LEfSe) analysis, the culture conversion group exhibited decreasing taxa at various levels (phylum/genus/species), but no significant increase in taxa was observed. LEfSe analysis of the refractory patient group revealed multiple taxa decreased during treatment. However, proportions of Veillonella dispar (LDA = 4.78), Fusobacterium periodonticum (LDA = 4.35), and Pseudomonas aeruginosa (LDA = 2.92) increased as the treatment period progressed in the refractory group. Sputum microbiota diversity decreases during NTM-PD treatment. In the culture conversion group, most taxa decrease, while some increase in the refractory group. These findings suggest that a distinct respiratory microbial community may exist in refractory NTM-PD patients compared to responsive antibiotic-treated patients.
FSSDD: Few‐shot steel defect detection based on multi‐scale semantic enhancement representation and mask category information mapping
Authors: Liu Zhoufeng , Guo Zijing , Li Chunlei , Huang Ning , Gao Chengli 
Published: November 2023

AbstractSteel defect detection is important for industry production as it is tied to the product quality and production efficiency. However, previous steel defect detection methods based on deep convolutional neural networks heavily rely on large‐scale data for training and tend to have poor generalization ability for a novel defect category. In this paper, a novel few‐shot steel defect detection model based on multi‐scale semantic enhancement representation and mask category information mapping is introduced, where only a few annotated samples are acquired for the novel defect category. More concretely, three main components are built: an information‐guidance enhanced multi‐head detector is proposed to improve the representation of information in meta‐feature maps, a mask category representation module is designed to enhance the category feature representation of the mask region in the support set, and a novel multi‐scale category edge loss function is designed to assist the generation of category reweighting vector. Extensive experiments on the North‐east University few‐shot steel defect data set demonstrate that the proposed method significantly outperforms the state‐of‐the‐art methods and verify its effectiveness through ablation studies.
Optimal combined wake and active power control of large‐scale wind farm considering available power
Authors: Chen Weimin , Wang Pengda , Huang Sheng , Huang Lingxiang , Tang Wenbo , Wu Qiuwei 
Published: November 2023

AbstractThe high‐order nonlinear complex characteristics of traditional static wake model (SWM) restrict the fast optimization of wake effect. Therefore, this paper introduces a dynamic wake model (DWM) to describe the time‐varying wake characteristics of wind turbines (WTs) with low computational cost. The traditional SWM is linearized to derive the wake wind speed sensitivity coefficients, which represents the sensitivity of wake wind speed deficit with respect to the active power reference. Considering the natural propagation characteristics of wake effect, a wake delay function is added to realize the future wind speed prediction of different locations of the wind farm. And a joint control strategy of wake and active power based on model predictive control (MPC) is proposed to optimize the power contribution of each WT to minimize wake effects, and maximize total available power. Thus, the increased available power is able to satisfy the power demand from Transmission System Operator (TSO) for ancillary services and enhance power support capability. The control performance of the proposed control strategy is evaluated by simulations under constant and varying incoming wind speed.
Equivalent transmission line characterization and multi‐layer material measurement analysis of the signal conversion process in the pulsed electro‐acoustic method
Authors: Ren Hanwen , Zhao Siyang , Mu Jian , Gao Haoyu , Qi Tianrun , Han Zhiyun , Li Zhihui , Li Qingmin 
Published: November 2023

AbstractThis paper studies the equivalent transmission line model of the pulsed electro‐acoustic (PEA) method with its applications. Based on the consistency of acoustic wave behaviour inside lossy acoustic materials and voltage wave propagation in transmission line, an equivalent simulation model of the PEA system is developed, whose reliability is verified by the output from the transducer and amplifier models and the comparison with measured waveforms. For the problem of acoustic impedance mismatch between different modules, simulation indicates that the unequal impedances of semiconducting electrode and sample can affect the amplitude of the measured signal at the upper electrode side, and the reflected acoustic waves caused by the transducer can affect the charge waveform. Further simulation for multi‐layer materials finds that the reflected acoustic waves of different samples and sound absorbing module can superimpose on the charge signal. Accordingly, a selection criterion is proposed to avoid the effect of the reflected waves at the interface. As for the acoustic reflection caused by internal charge, it needs to be dealt with sequentially in calibration process, starting from the result inside the sample near ground electrode. The research can provide a foundation for analyzing the acoustic properties of the PEA method.
Ethical Considerations in Follicular Unit Excision Surgical Procedures
Authors: Rose Paul T. 
Published: November 2023

AbstractFollicular unit excision (FUE) is an increasingly popular hair restoration technique. In many instances, it surpasses linear strip excision (LSE) surgery in terms of number of procedures and clinics dedicated to performing FUE. The rise in popularity relates primarily to a somewhat misguided perception that FUE produces less evidence of a surgical procedure having been performed. This is based on the fact that a linear scar is avoided. The procedure is easier to learn and “less invasive” as compared to LSE harvesting and requires less staff and capital expense. The FUE procedure is aggressively marketed often as “scarless surgery.” This false statement, along with the ease of starting an FUE practice, has resulted in various ethical issues related to evaluation, methodology, and business practices. In this chapter, we discuss the ethical issues surrounding FUE hair restoration surgery and the examination of the mathematics of donor management as it relates to the ethical management of the FUE patient.
Management of Ptosis in Kearns–Sayre Syndrome: A Case Report and Literature Review
Authors: Moustaine Moulay O. , Azemour Zakaria , Mohammed Frarchi , Benlanda Othman , Nassik Hicham , Karkouri Mehdi 
Published: November 2023

AbstractKearns–Sayre syndrome (KSS) is a rare mitochondrial disease that affects young adults, due to a deletion of mitochondrial DNA and characterized by the triad: age of onset lower than 20 years, chronic progressive external ophthalmoplegia, and an atypical pigmentary retinopathy. It is also characterized by other endocrine, neurological, and especially cardiac impairment with a very high risk of cardiac complications during surgical procedures under all types of anesthesia.We report a case of KSS revealed by severe bilateral ptosis and confirmed by a muscle biopsy with “ragged red fibers.” The ptosis was surgically managed by cautious Frontal suspension under local anesthesia “Frontal nerve block.” Through this case, we discuss challenges in the management of KSS patients.
Lung Protective Ventilation during Pregnancy: An Observational Cohort Study
Authors: Kislovskiy Yasaswi , Hauspurg Alisse , Donadee Chenell , Sakamoto Sara , Murugan Raghavan 
Published: November 2023

Objectives We sought to describe characteristics of mechanically ventilated pregnant patients, evaluate utilization of low-tidal-volume ventilation (LTVV) and high-tidal-volume ventilation (HTVV) by trimester, and describe maternal and fetal outcomes by ventilation strategy.
Study Design This is a retrospective cohort study of pregnant women with mechanical ventilation for greater than 24 hours between July 2012 and August 2020 at a tertiary care academic medical center. We defined LTVV as average daily tidal volume 8 mL/kg of less of predicted body weight, and HTVV as greater than 8 mL/kg. We examined demographic characteristics, maternal and fetal characteristics, and outcomes by ventilation strategy.
Results We identified 52 ventilated pregnant women, 43 had LTVV, and 9 had HTVV. Acute respiratory distress syndrome occurred in 73% (N = 38) of patients, and infection was a common indication for ventilation (N = 33, 63%). Patients had LTVV more often than HTVV in all trimesters. Obstetric complications occurred frequently, 21% (N = 11) experienced preeclampsia or eclampsia, and among 43 patients with available delivery data, 60% delivered preterm (N = 26) and 16% had fetal demise (N = 7).
Conclusion LTVV was utilized more often than HTVV among pregnant women in all trimesters. There was a high prevalence of maternal and fetal morbidity and fetal mortality among our cohort.
Key Points
Missed connections: A resource-management theory to combat loneliness experienced by globally mobile employees
Authors: Fan Shea X. , Zhu Fei , Shaffer Margaret A. 
Published: November 2023

Abstract
All globally mobile employees (GMEs) share a common propensity to experience loneliness when they relocate to a new country where they have yet to establish social connections. To better understand how GMEs combat this feeling, we offer a conceptual process model grounded in conservation of resources (COR) theory to describe how they achieve social integration. The process begins with an assessment of GMEs’ desired versus perceived social relations, with most perceiving a relational deficiency or loneliness. This then triggers an audit of available social resources, which we differentiate in terms of source (personal vs. contextual) and stability (enduring vs. transient) to develop a typology of resources. Depending on the availability of resources, GMEs will follow one of three resource-management pathways to become socially integrated. Those who choose an expansion pathway will achieve what we refer to as deep-level (authentic) social integration and those who follow a protection pathway will attain surface-level (functional) social integration. The underutilization pathway is an interim route that may lead to either a resource-expansion or resource-protection pathway depending on changes in the availability of resources. Our iterative and recursive cyclical process model has implications for international management research, workplace loneliness studies, and COR theory.
An integrated approach to evaluate the measurement capability and acceptability of acoustic emission sensors
Authors: Chen Haizhou , Lin Janet , Chen Nian , Xu Guanji 
Published: November 2023

Abstract
Acoustic emission (AE) is a pivotal technique in condition-based maintenance (CBM) and recent years have witnessed a significant surge in the deployment of AE sensors in industrial applications. With this increase in availability, there comes a substantial challenge: evaluating the measurement capability of sensors within specific applications. As such, this study identifies a critical need for a structured approach to evaluate the measurement capabilities of AE sensors and subsequently judge their acceptability against guideline criteria. To address this need, we present an integrated approach that systematically guides the capability evaluation of AE sensors, incorporating both qualitative and quantitative analyses. The qualitative analysis aims to scrutinize the diagnostic accuracy of sensors by assessing the detectability of features critical for diagnostics. The quantitative analysis leverages the Gage repeatability and reproducibility (Gage R&R) to statistically evaluate sensor characteristics. A comprehensive experimental study further investigates the impact of measurement sources on the sensors’ repeatability, and reproducibility. This study illustrates the qualitative findings regarding sensor’s diagnostic accuracy in both time and frequency domains, revealing promising performance in diagnostic-based evaluations. In quantitative analysis, we demonstrate the results of sensor capability in terms of repeatability and reproducibility, providing the variations of different sources in statistics-based evaluations. We thoroughly investigate the influence of significant factors, quantifying their contributions to the sensor’s measurement capability. Furthermore, we introduce metrics designed to assess sensor’s acceptability, according to explicit acceptance and rejection criteria. Our experimental results affirm that root mean square measurements are within acceptable ranges for both sensors, while spectral entropy (SE) measurements for PK15I sensor satisfy the acceptable level. For HZ136I sensor, however, SE measurements are deemed conditionally acceptable. Ultimately, the proposed approach provides a robust framework for the comprehensive evaluation of AE sensor measurement capabilities, offering invaluable guidance for sensor selection and enhancement in industrial applications.
On the metric upper density of Birkhoff sums for irrational rotations
Authors: Frühwirth Lorenz , Hauke Manuel 
Published: November 2023

Abstract
This article examines the value distribution of

S

N

(
f
,
α
)
:=

∑

n
=
1

N

f
(
n
α
)

for almost every α where

N
∈

N

is ranging over a long interval and f is a 1-periodic function with discontinuities or logarithmic singularities at rational numbers. We show that for N in a set of positive upper density, the order of

S

N

(
f
,
α
)

is of Khintchine-type, unless the logarithmic singularity is symmetric. Additionally, we show the asymptotic sharpness of the Denjoy–Koksma inequality for such f, with applications in the theory of numerical integration. Our method also leads to a generalized form of the classical Borel–Bernstein Theorem that allows very general modularity conditions.
Early warning for abnormal strains of continuous bridges using a proposed temperature–strain mapping model
Authors: Gong Xiaoyu , Song Xiaodong , Cai C S , Li Guangqi , Xiong Wen 
Published: November 2023

Abstract
Bridge strain is an essential monitoring index for small to medium span bridges because abnormal strains could be attributed to bridge deterioration or damage. Thus, an early warning method for detecting abnormal strains is highly desired. In this study, a temperature–strain mapping model for predicting the temperature induced strains was proposed by fusing structural health monitoring data and deep learning neural networks. First, the sensitivity of temperature induced strains to structural damage was analyzed, and the thermal strain was chosen as a suitable indicator for bridge performance detection. Next, a high-precision prediction model was established to overcome the time-lag effect between the original temperature and temperature induced strain sequences. By comparing the model’s prediction with the identification of measurements, an early warning method for detecting the abnormal temperature induced strains was proposed. The evaluation results demonstrated that the proposed early warning method was able to accurately detect the abnormal strains, even when the abnormal strain is smaller than the normal daily variations.
A novel joint-less coil: promising unprecedented magnetic field stability to solve the persistent current mode issue in 2G-HTS magnet application
Authors: Dong Hao , Huang Daxing , Wang Tongxin , Gu Hongwei , Ding Fazhu 
Published: November 2023

Abstract
Closed coils fabricated using second generation high temperature superconducting (2G-HTS) coated conductors (CCs) are promising for superconducting magnets, which operating in persistent current mode (PCM) such as magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) systems. However, the fabrication and application of superconducting joints for 2G-HTS CCs still pose a significant challenge. This paper reports a PCM joint-less 2G-HTS coil for capturing magnetic fields, which is called ‘Four Pancake Coil (FPC)’. A novel winding method was developed to form four pancake structure and effectively solved the closed-loop problem of 2G-HTS magnets. Meanwhile, the FPCs generated a 70.4 mT central magnetic field at 77 K and lasted for 57 d with a magnetic field drift rate of only 0.065 ppm h−1, which can satisfy the requirements of MRI magnets. In addition to the closed-loop characteristics of the FPC, the stacked magnet also provides expandability and ease of maintenance exchange. These advantages make it highly promising for the development of closed-loop 2G-HTS magnets.