bluuebunny/crossref_metadata_2025_split huggingface dataset:
The experiences of reproductive concerns in cancer survivors: A systematic review and meta‐synthesis of qualitative studies
Authors: Dong Ying , Yue Zhenyu , Zhuang Huan , Zhang Chen , Fang Yu , Jiang Guichun 
Published: December 2023

AbstractAimThe aim of this study was to synthesize qualitative research evidence on cancer survivors' experiences with reproductive concerns (RC).MethodsWe conducted a systematic search of qualitative studies and utilized the meta‐aggregation approach. The database searches were extended up to May 14, 2023, encompassing 12 databases, specifically MEDLINE, CINAHL, PubMed, EMBASE, Scopus, Web of Science (Core Collection), AMED, PsycINFO, The Cochrane Library, CNKI, Wan Fang Data, and VIP.ResultsThree overarching themes were synthesized from the analysis of 21 studies that explored cancer patients' awareness of reproductive concerns, their perceptions, needs, and coping styles. These themes encapsulate the multifaceted aspects of cancer patients' reproductive concerns: “Gender differences in fertility concerns among cancer patients: Perspectives from men and women”; “The influence of age: Experiences with fertility issues among cancer patients at different life stages”; “The impact of treatment stages on fertility concerns: The evolution of perception and coping strategies in the course of cancer treatment”.ConclusionOur study presents an in‐depth exploration of the reproductive concerns experienced by cancer patients from various perspectives. We found that the internal experiences of reproductive concerns, their perceptions, needs, and coping mechanisms differ based on their roles. This comprehensive understanding of the complex emotions and needs of cancer patients when confronted with fertility issues can guide clinicians in providing more effective medical assistance, psychological counseling, and fertility‐related information services.
Risks of hypertension and thromboembolism in patients receiving bevacizumab with chemotherapy for colorectal cancer: A systematic review and meta‐analysis
Authors: Chitkara Akshit , Kaur Nirmaljot , Desai Aditya , Mehta Devanshi , Anamika Fnu , Sarkar Srawani , Gowda Nandini , Sethi Prabhdeep , Thawani Rajat , Chen Emerson Y. 
Published: December 2023

AbstractBackgroundGuidelines show that for metastatic colorectal cancer (mCRC), a combination of three‐drug regimens, fluorouracil, leucovorin, and oxaliplatin and bevacizumab (BVZ), is one of the first‐line standard therapies. BVZ is generally well tolerated; however, it is associated with infrequent, life‐threatening side effects such as severe hypertension (HTN) (5%–18%), Grade ≥3 arterial thromboembolism (ATE) (2.6%), Grade ≥3 hemorrhagic events (1.2%–4.6%), and gastrointestinal perforation (0.3%–2.4%). This meta‐analysis aims to evaluate the additive risk of BVZ‐induced severe HTN and thromboembolism when BVZ is combined with a standard chemotherapy regime in patients with mCRC.MethodsOur search was conducted from January 29, 2022, to February 22, 2022, through databases of PubMed, clinicaltrial.gov, EMBASE, Web of Science, and Cochrane Library. Data analysis from randomized controlled trials (RCTs) and clinical trials was conducted using Review Manager V.5.4, comparing BVZ‐chemotherapy to chemotherapy only, focusing on cardiovascular AE such as HTN and arterial and venous thromboembolism.ResultsThe analysis from 26 clinical trials and RCTs showed that the odds of HTN were about four times higher, and ATE subgroup analysis of 11 studies showed over two times higher odds of ATE in patients being treated with BVZ compared to the chemotherapy‐only group.ConclusionBVZ, when added to the standard chemotherapy regimen for mCRC, was associated with higher odds of developing HTN and thromboembolism, specifically ATE, than the chemotherapy‐only group. Our findings are significant as they provide vital information in analyzing the risk–benefit ratio of adding BVZ to the standard chemotherapy regime in patients with mCRC, especially in patients with vascular comorbidities.
Utilization of cardiac tests in anthracycline‐treated cancer survivors differs between young adults and children: A claims‐based analysis
Authors: Ji Xu , Hu Xin , Lipscomb Joseph , Chow Eric J. , Mertens Ann C. , Castellino Sharon M. 
Published: December 2023

AbstractBackgroundThe Children's Oncology Group Guidelines recommend a cardiacechocardiogram, or comparable functional imaging, following therapy completion in survivors of childhood/adolescent cancers exposed to anthracyclines.MethodsUsing the 2009–2019 Merative™ MarketScan® Commercial Database, we examined real‐world utilization of cardiac testing among 1609 anthracycline‐treated survivors of childhood/adolescent cancers.ResultsThe cumulative incidence of receiving an initial cardiac test by 5.25 years from the index date (six months after end‐of‐therapy) was 62.3% (95% CI = 57.5%–66.7%), with median time to initial test being 2.7 years (95% CI = 2.5%–3.1%). Young adults (18–28 years) were less likely than children (≤17 years) to receive cardiac testing (hazard ratio [HR] = 0.42, 95% CI = 0.3%–0.49%). More likely to receive cardiac testing were survivors receiving hematopoietic stem cell transplantation versus chemotherapy only (HR = 2.23, 95% CI = 1.63%–3.03%), and survivors with bone or soft tissue versus hematologic cancer (HR = 1.64, 95% CI = 1.30%–2.07%).ConclusionsNearly 40% of anthracycline‐treated survivors of childhood/adolescent cancers had not received cardiac testing within 5.25 years post‐index date, with young adults least likely to receive a test.
PANoptosis in cancer, the triangle of cell death
Authors: Cai Hantao , Lv Mingming , Wang Tingting 
Published: December 2023

AbstractBackgroundPANoptosis is a novel form of programmed cell death (PCD) found in 2019 that is regulated by the PANoptosome. PANoptosis combines essential features of pyroptosis, apoptosis, and necroptosis, forming a “death triangle” of cells. While apoptosis, pyroptosis, and necroptosis have been extensively studied for their roles in human inflammatory diseases and many other clinical conditions, historically they were considered as independent processes. However, emerging evidence indicates that these PCDs exhibit cross talk and interactions, resulting in the development of the concept of PANoptosis.MethodsIn this review, we offer a concise summary of the fundamental mechanisms of apoptosis, pyroptosis, and necroptosis. We subsequently introduce the notion of PANoptosis and detail the assembly mechanism of the PANoptosome complex which is responsible for inducing cell death. We also describe some regulatory networks of PANoptosis.ResultsPANoptosis now has been associated with various human diseases including cancer. Although the exact function of PANoptosis in each tumor is not fully understood, it represents a prospective avenue for cancer therapy, offering promise for advancements in cancer therapy.ConclusionsIn the future, in‐depth study of PANoptosis will continue to help us in understanding the fundamental processes underlying cell death and provide scientific support for cancer research.
Differential co‐expression network analysis elucidated genes associated with sensitivity to farnesyltransferase inhibitor and prognosis of acute myeloid leukemia
Authors: Kelesoglu Nurdan , Kori Medi , Yilmaz Betul Karademir , Duru Ozlem Ates , Arga Kazim Yalcin 
Published: December 2023

AbstractAcute myeloid leukemia (AML) is a heterogeneous disease and the most common form of acute leukemia with a poor prognosis. Due to its complexity, the disease requires the identification of biomarkers for reliable prognosis. To identify potential disease genes that regulate patient prognosis, we used differential co‐expression network analysis and transcriptomics data from relapsed, refractory, and previously untreated AML patients based on their response to treatment in the present study. In addition, we combined functional genomics and transcriptomics data to identify novel and therapeutically potential systems biomarkers for patients who do or do not respond to treatment. As a result, we constructed co‐expression networks for response and non‐response cases and identified a highly interconnected group of genes consisting of SECISBP2L, MAN1A2, PRPF31, VASP, and SNAPC1 in the response network and a group consisting of PHTF2, SLC11A2, PDLIM5, OTUB1, and KLRD1 in the non‐response network, both of which showed high prognostic performance with hazard ratios of 4.12 and 3.66, respectively. Remarkably, ETS1, GATA2, AR, YBX1, and FOXP3 were found to be important transcription factors in both networks. The prognostic indicators reported here could be considered as a resource for identifying tumorigenesis and chemoresistance to farnesyltransferase inhibitor. They could help identify important research directions for the development of new prognostic and therapeutic techniques for AML.
How self‐injury affects psychotherapists: A qualitative study
Authors: O'Connor Cindy , Surgenor Paul 
Published: December 2023

AbstractIntroductionInterpretative phenomenological analysis (IPA) is used to explore how people make sense of their personal and social world, although a search of recent literature suggests that it has not been applied to better understand self‐injury (SI). The goal of this paper was to employ an IPA methodology to gain a deeper understanding of the impact witnessing the physical manifestations of SI has on therapists.MethodThe study recruited a purposive sample of nine English‐speaking psychotherapists. Questions designed to relate to the participant's experience of witnessing the physical manifestations of SI were piloted with non‐participating psychotherapists whose experience matched those of the sample. Individual interviews were conducted by the primary researcher.Data AnalysisAnalysis involved the hermeneutic circle, moving between the part and the whole to capture and record the unique experience of the individual participants. This entailed the following: reading and re‐reading the transcripts; initial noting; developing emergent themes; connecting emergent themes; and pattern identification across cases.ResultsTwo superordinate themes were identified that encapsulated how participants experienced, perceived and understood their own reactions to clients’ SI presentation. The first, Shock, included the subordinate themes of Controlling reactions, Managing physical revulsion, Therapeutic holding and Revisiting and ruminating. The second, Responsibility, included the subordinate themes of Client responsibility, Professional responsibility, Personal responsibility and Responsibility for hope.ImplicationsImplications relate to core training for psychotherapists, the focus on continuing professional development, and the policies and procedures needed to support psychotherapists.
Discovery of Novel Marine‐Derived Phidiandine/Lipoic Acid Hybrid as a Potential Anti‐Atherosclerosis Agent: Design, Synthesis and in Vitro/in Vivo Evaluation
Authors: Liu Shu‐Jun , Zhong Ying‐Nan , Cheng Zhi‐Qiang , Meng Ning , Zhang Juan , Jiang Cheng‐Shi 
Published: December 2023

AbstractIn the present study, a novel derivative, IOP‐LA, was prepared by hybridizing antioxidant lipoic acid (LA) and our recently reported antioxidative marine phidianidine B‐inspired indole/1,2,4‐oxadiazole derivative. Our results demonstrated that IOP‐LA could protect vascular endothelial cells (VECs) from oxidized low‐density lipoprotein (oxLDL)‐induced oxidative stress by activating the Nrf2 pathway, inhibit the production of atherosclerotic plaque, and promote the stability of atherosclerotic plaque in apoE−/− mice. Moreover, the protective effect of IOP‐LA was superior to LA at the same concentration. Mechanistic studies revealed that IOP‐LA significantly inhibited the increase of reactive oxygen species (ROS) levels and the translocation of nuclear factor kappa‐B (NF‐κB) nuclear induced by oxLDL through the nuclear factor erythroid2‐related factor 2 (Nrf2) pathway. In summary, the data demonstrate that IOP‐LA, as a new antioxidant, protects VECs from oxLDL‐induced oxidative stress by activating the Nrf2 pathway. It is worth noting that this study provides a promising lead compound for the prevention and treatment of atherosclerosis.
Recovery of root hydraulic conductance and xylem vessel diameter following prolonged water deficit of maize
Authors: Jafarikouhini Nahid , Sinclair Thomas R. 
Published: December 2023

AbstractTo sustain crop growth following soil water deficit, it is essential to have rapid recovery of leaf gas exchange. One basis for rapid recovery would be the rapid return of root hydraulic conductance to predrought levels to support water transport to the plant shoot. In this study, transpiration and root hydraulic conductance were measured over a 9‐day recovery period following an initial water‐deficit treatment of three maize (Zea mays L.) cultivars. In addition, xylem vessel diameter was measured during the recovery period at different positions from the root tip. The initiation of recovery in the transpiration rate occurred in all three cultivars within 3 days after watering, although the root conductance and transpiration rate of one cultivar were much lower than the other two cultivars. Root conductance and vessel diameter increased more slowly than the recovery of transpiration. There was an indication that transpiration could have been limited by root hydraulic conductance only when its values were low during recovery. The relationship between hydraulic conductance and vessel diameter did not, however, indicate a Poiseuille's law relationship between the two variables. Overall, cultivar variability in recovery from water deficit of the transpiration rate and root hydraulic conductance indicates that the selection for rapid recovery of leaf gas exchange following water deficit could be an important component of genotype selection in maize breeding programs.
Impact of the COVID‐19 pandemic on care for anorexia and bulimia nervosa in US military‐connected adolescents and young adults
Authors: Lawson Michelle L. , Hisle‐Gorman Elizabeth , Susi Apryl , Dorr Madeline , Nylund Cade M. , Chokshi Binny 
Published: December 2023

AbstractObjectiveThis study examined the impact of the COVID‐19 pandemic on healthcare engagement for anorexia nervosa (AN) and bulimia nervosa (BN) in a large, geographically diverse population.MethodThis repeated monthly, cross‐sectional study queried Military Health System records of individuals aged 10–21 before and during the pandemic (February 2019–January 2022). ICD‐10 codes identified encounters for AN and BN. Monthly rates of care were modeled as the number of unique individuals with an ICD‐10‐identified eating disorder‐related encounter per month divided by the enrolled population. Poisson regression analysis evaluated rates of care stratified by eating disorder, clinical setting, and sex.ResultsIn a population of 1.76 million adolescents and young adults, 1629 individuals with AN or BN received care during the pre‐pandemic period; 3256 received care during the pandemic. The monthly rate of care for females with AN during the pandemic increased in inpatient settings (adjusted relative risk [aRR]: 1.31 [1.16–1.49]) and outpatient settings (aRR: 1.42 [1.37–1.47]); monthly care rates in males with AN increased in the outpatient setting (aRR: 1.46 [1.28–1.67]). Females with BN had increased engagement in outpatient settings (aRR: 1.09 [1.03–1.16]); BN care for males showed no significant monthly changes during the pandemic period in either healthcare setting.DiscussionWith increased rates of AN and BN disorder‐related care during the pandemic, screening for eating disorder symptomatology may allow for timely diagnosis and intervention in periods of heightened stress. Pandemic‐related increases in healthcare engagement may strain limited resources, emphasizing a need to expand accessibility of clinical expertise.Public SignificanceThis study indicates that monthly rates of healthcare engagement during the COVID‐19 pandemic for AN and BN varied based on clinical setting and sex in an adolescent and young adult population. The increased number of individuals seeking eating disorder‐related care, especially outpatient care, attributed to heightened stressors necessitates accessible professionals with eating disorder clinical expertise.
Efficient Synthesis of Highly Fused Quinazolinone Derivatives via Multiple C−C Bond Formations and 1,4‐Palladium Migration
Authors: Thavaselvan Sampath , Arumugam Natarajan , Almansour Abdulrahman I. , Mahalingam Sakkarapalayam M. , Parthasarathy Kanniyappan 
Published: December 2023

AbstractAn efficient palladium‐catalyzed annulation of 3‐arylquinazolinones with mono and double alkyne insertion was developed for the synthesis of fused quinazolinone derivatives in 43–80 % yields. A notable effect was observed in product yield, when bases/additives were modulated. The reaction mechanism is believed to proceed through C−X cleavage/alkyne insertion/1,4‐Pd migration and C−H annulation in a one‐pot manner.
EnhancingEEGsignals classification usingLSTM‐CNNarchitecture
Authors: Omar Swaleh M. , Kimwele Michael , Olowolayemo Akeem , Kaburu Dennis M. 
Published: December 2023

AbstractEpilepsy is a disorder that interferes with regular brain activity and can occasionally cause seizures, odd sensations, and momentary unconsciousness. Epilepsy is frequently diagnosed using electroencephalograph (EEG) records, although conventional analysis is subjective and prone to error. The dynamic and non‐stationary nature of EEG structure restricted the performance of Deep Learning (DL) approaches used in earlier work to improve EEG classification. Our multi‐channel EEG classification model, dubbed LConvNet in this paper, combines Convolutional Neural Networks (CNN) for extracting spatial features and Long Short‐Term Memory (LSTM) for identifying temporal dependencies. To discriminate between epileptic and healthy EEG signals, the model is trained using open‐source secondary EEG data from Temple University Hospital (TUH). Our model outperformed other EEG classification models employed in comparable tasks, such as EEGNet, DeepConvNet, and ShallowConvNet, which had accuracy rates of 86%, 96%, and 78%, respectively. Our model attained an amazing accuracy rate of 97%. During additional testing, our model also displayed excellent performance in trainability, scalability, and parameter efficiency.
Integration of Industry 4.0 with reliability centered maintenance to enhance sustainable manufacturing
Authors: Jena Madhab Chandra , Mishra Sarat Kumar , Moharana Himanshu Sekhar 
Published: December 2023

AbstractAchieving sustainability in manufacturing requires optimizing reliability and productivity while reducing environmental impact. This article introduces a novel approach by integrating Industry 4.0 technologies with reliability centered maintenance (RCM) to create a “smart RCM” model. In an era where Industry 4.0 leverages the Internet of Things (IoT), cyber physical systems (CPSs), cloud computing, and cognitive computing, this integration transforms conventional RCM into a data‐driven and efficient system. A case study conducted in a cement plant illustrates the benefits of smart RCM implementation. Key performance indicators (KPI), including increased production volume, reduced downtime, enhanced mean time between failures (MTBF), and improved overall equipment effectiveness (OEE), showcase the positive impact of smart RCM. Furthermore, specific environmental performance indicators, such as energy consumption, carbon footprint, and water consumption, exhibit favorable changes, contributing to sustainability. The implementation of smart RCM also presents an attractive payback period, making it an appealing approach for industries looking to optimize maintenance practices and environmental performance. Despite potential challenges in workforce adaptation and resistance, the integration of Industry 4.0 with RCM emerges as a transformative strategy.
The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview
Authors: MasoudKabir Farzad , Bayani Reyhaneh , Mousavi Darzikolaee Nima , Abdshah Alireza , Moshtaghian Mahsa , Farhan Farshid , Aghili Mahdi , Kazemian Ali , Nicosia Luca , Cuccia Francesco , Rocha Ana Vitoria , Jafari Fatemeh , Alongi Filippo 
Published: December 2023

AbstractIntroductionCardiac arrhythmias, including ventricular tachycardia (VT), stand as a significant threat to health, often leading to mortality and sudden cardiac death. While conventional treatments for VT exhibit efficacy, cases of refractory VT pose challenges. Stereotactic Arrhythmia Radioablation (STAR) offers a novel approach, delivering precise high‐dose radiation to well‐defined targets with minimal collateral damage. This study explores the potential of STAR as an alternative therapy, especially for high‐risk patients or those with refractory VT.MethodsThis research reviews ongoing studies and preliminary investigations into the evaluation of the efficacy and safety of STAR. The method involves targeted radiation delivery, assessing reductions in VT recurrence and the early safety profile in refractory VT patients. However, given STAR's early stage and limited clinical evidence, cautious interpretation is advised.ResultsPreliminary findings indicate a reduction in VT recurrence with STAR, suggesting promise as a therapeutic option. Early safety profiles are encouraging, but definitive statements on efficacy and safety require further investigation. Positive initial outcomes underscore the need for additional data and long‐term studies.ConclusionStereotactic Arrhythmia Radioablation is recently emerging as a promising treatment for refractory VT. While early results are encouraging, careful interpretation is needed, due to STAR's early stages. Ongoing investigations are critical for a comprehensive understanding of its long‐term efficacy and tolerability. This review provides fundamental insights into STAR's background, principles, pre‐treatment procedures, clinical implications, and toxicity, setting the stage for future research in this evolving therapeutic field.