bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS BEBERAPA SIFAT KIMIA TANAH PADA DUA MACAM PENGGUNAAN LAHAN DI SUNGAI KAKAP, KABUPATEN KUBU RAYA, KALIMANTAN BARAT
Authors: Fadilla Ulfia , Nusantara Rossie Wiedya , Manurung Rinto 
Published: January 2024

Paddy fields and mixed farming apply intensive agricultural cultivation, and sustainable land use causes changes in land quality, one of which affects soil chemical properties. This study aimed to compare soil chemical properties based on differences in the use of paddy fields and mixed farming in Sungai Kakap District, Kubu Raya Regency, West Kalimantan. Research in the field in Pal IX Village, Sungai Kakap Sub-district, Kubu Raya Regency, for sampling soil samples at 0-20 cm depth. Soil analysis was conducted at the Chemistry and Soil Fertility Laboratory, Faculty of Agriculture, Tanjungpura University. The results showed that the two fields, paddy fields, and mixed farming, had almost the same chemical properties in paddy fields pH, organic C, available P, cation exchange capacity (CEC), exchangeable Ca and exchangeable Mg.
PEMANFAATAN KOMPOS DAN MIKORIZA UNTUK MEMPERBAIKI KESUBURAN TANAH, PERTUMBUHAN SERTA PRODUKSI TANAMAN JAGUNG MANIS (Zea mays saccharata)
Authors: Rajagukguk Reinhard Novando , Nuraini Yulia 
Published: January 2024

Inceptisols dominate Indonesia's land area; therefore, future utilization needs to be maximized, especially land that has undergone extensive tillage continuously. Inceptisols have low levels of essential nutrients, especially nitrogen, phosphorus, and potassium. One of the efforts that can be made to improve nutrient content is the application of compost. This study aimed to investigate the effect of compost combined with mycorrhiza on total N, available P, exchangeable K, and soil organic C, as well as the growth and yield of sweet corn. The experimental design used in this study was a completely randomized design consisting of five treatments with three replications. Each observation parameter was analyzed using the F test at the 5% level. Parameters that significantly affected the F test were followed by the DMRT test at the 5% level. All observed data were tested for correlation using SPSS V24 to see the relationship between observation parameters. The results showed that the application of a combination of compost and mycorrhizae increased total N content by 78.7%, available P by 26.6%, soil organic C by 29.54%, plant height by 143.87cm, number of leaves by 11.33 leaves, and cob weight by 294.33 g compared to control. The correlation test showed that applying a combination of compost and mycorrhiza affected N in the soil, so the growth and yield of corn were higher.
Promoting Return to Work After Vocational Rehabilitation Using a Work-Related Fitness App: Protocol for a Cluster-Randomized Controlled Trial
Authors: Bühne David , Elling Jan Mathis , Hetzel Christian , Alles Torsten 
Published: January 2024

Background
Retraining programs in vocational rehabilitation are often characterized by a low level of physical activity, even when targeting jobs with primarily physical demands. They might therefore be accompanied by a decline in functional capacity if the lack of physical activity is not compensated by increased activity during leisure time. The implementation of a work-related exercise app might be a promising approach to promoting a return to work in vocational rehabilitation. We developed the “WORKout-app” which provides exercise plans based on a comparison of the physical demands of the retraining profession and the current functional capacity.

Objective
The aim of this study is to examine the effects of app-based exercise during vocational rehabilitation on perceived work ability (primary outcome), occupational self-efficacy, days of sick leave, and return to work (secondary outcomes).

Methods
We conducted a cluster-randomized controlled trial with 2 arms (intervention: WORKout-app vs control: treatment as usual) in 4 cohorts of 5 vocational rehabilitation centers in Germany. Participants are nested within retraining classes per vocational rehabilitation center and per cohort assigned to either the intervention condition or the control condition. The target sample size at the participant level is 598. Measurement time points include baseline, the end of rehabilitation, 3 months after the end of rehabilitation, and 6 months after the end of rehabilitation. Linear and generalized linear mixed-effects models are performed to test for treatment differences in outcomes.

Results
This study is funded by the German Federal Pension Insurance. The trial is registered with the German Clinical Trials Register (DRKS00030775) and approved by the Ethics Committee of the German Sport University Cologne (145/2022).

Conclusions
The findings of the study will inform researchers and practitioners about the effectiveness of an exercise app developed to counteract the effects of physical inactivity during vocational rehabilitation.

International Registered Report Identifier (IRRID)
DERR1-10.2196/50200
Asthma in pregnant woman and its management : a review
Authors: Farni Yuliana Pratiwi  , Hadiatussalamah  , Intan Adevia Rosnarita  , Yuda Anzas Mara  , Novia Ariani Dewi  
Published: January 2024

Asthma is the most common comorbidity in pregnant women and gives 30% of exacerbation experience. The other 30% will see improvement of their symptoms, and the rest will not see the changes. Exacerbations have become a major clinical concern in pregnant women. Medical concerns for the mother and the childbirth included low birth weight, preeclampsia, and preterm delivery. The major goal is to keep asthma under control to ensure mother's health and well-being, as well as fetal growth. Controlling asthma and preventing exacerbations are the main goals of asthma treatment during pregnancy. Treatment for asthma should ideally begin before conception. This is to avoid day-time and night-time symptoms, as well as to keep lung function. Furthermore, fetal oxygenation is a crucial factor during the pregnancy. With a few exceptions, asthma drugs are basically the same in pregnancy as they are in non-pregnant people. Inhaled corticosteroids (ICS) are often used as a controlling treatment. Budesonide is the recommended ICS. Short-acting β-agonist (SABA) preferable as reliever in acute asthma and to relieve exacerbation. As an add-on therapy for medium to high dose ICS, long-acting β-gonists (LABA) is often used. Virus infections and ICS nonadherence are the two most common causes of asthma exacerbations during pregnancy.
Papillary thyroid carcinoma post total thyroidectomy: a case report
Authors: Darwito  , Ardha Doglas Rama Bayu , Sari Ika Puspita , Ridhayani Firda 
Published: January 2024

Thyroid malignancies are considered rare but it is the most common type of endocrine malignancy that increase rapidly over the past decades. Specifically, papillary thyroid carcinoma (PTC) in the pyramidal lobe is extremely rare. Herein, we described a case of recurrence case of PTC in the pyramidal lobe post total thyroidectomy with category VI T2N1M1 (Bethesda classification) with right neck lymph nodes metastasis at once and attempt to determine both clinical presentation and therapeutical strategies to overcome this case to diminish the possibility of tumor recurrence and optimize therapeutic outcomes for PTC recurrence. It was reported a 28 yo female with a diagnosis of PTC from the pyramidal lobe post-total thyroidectomy procedure. A definite diagnosis of PTC is important to understand the patient's condition and as a consideration to decide the appropriate procedure to cure it. The management of PTC with total thyroidectomy followed by removing the possible root source of recurrent PTC, such as the pyramidal lobe, is mandatory to minimize the residual thyroid tissue that dan influenced PTC recurrent. Even though almost all PTC has an excellent prognosis, periodic follow-up after surgery, and patients’ adherence to their medication are still required.
Prevalence and factors associated with uncontrolled blood pressure in dialysis patients using antihypertensive: a narrative review
Authors: Pulungan Yulianasari , Nugroho Agung Endro , Pramantara I Dewa Putu 
Published: January 2024

Hypertension in patients with end-stage chronic kidney disease undergoing hemodialysis is difficult to control leading to a significant risk factor for a cardiovascular event. The aimed of this review is to summarize the prevalence of uncontrolled blood pressure in dialysis patients. This review hopefully can serve as a valuable reference and source of insight for clinicians in their efforts to attain controlled blood pressure in dialysis patients. The relevant literatures was undertaken from PubMed, Scopus, and Google Scholar for studies addressing the factor associated with uncontrolled blood pressure in hemodialysis patients using antihypertensives from 2013 to 2023. Combinations of search terms were "uncontrolled" and "blood pressure" and "dialysis" and "antihypertensive”. Any study in English, including randomized control trials, cohort, case-control, and cross-sectional studies was included. Uncontrolled blood pressure is very common among hypertension in dialysis patients (28.7 - 78.33% of cases). Factors affecting blood pressure in dialysis patients include age, obesity, and comorbidity (diabetes and stage of chronic kidney disease). Although the relationship between gender, the number of antihypertensive, the number of dialysis, and the length of dialysis sessions with blood pressure varies, some studies have shown a positive association.
Improving hospital formulary drug decision making with multi-criteria decision analysis (MCDA): case study from a national government hospital in Indonesia
Authors: Kristin Erna , Bustami Mursyid , Pinzon Rizaldy Taslim , Alfi Yasmina  , Susanto Agnes , Febrinasari Ratih Puspita 
Published: January 2024

This study aimed to look at the applicability of the multi-criteria decision analysis (MCDA) framework to improve hospital formulary drug decision-making. The case study method was used to investigate MCDA implementation in the National Brain Center Hospital Jakarta, Indonesia. A two stage-workshop was held on October 29th, 2019 and 5 February 5th, 2020, where participants conducted a hands-on experience in applying MCDA for selecting off-patent pharmaceuticals (OPPs) for the hospital formulary. The results of the workshop created awareness of MCDA that can be beneficial in transparently selecting OPP, which is not based only on price while involving multiple stakeholders. As a follow-up, MCDA was used during the drug selection process for the National Brain Center Hospital formulary in 2021 with criteria in accordance with the workshops, namely: 1) equivalence with the reference (originator) product; 2) real-world clinical or economic outcomes; 3) quality assurance; 4) reliability of drug supply; 5) stability and drug formulation; 6) pharmacovigilance, and 7) price advantages. In conclusion, the MCDA method can be implemented with customized criteria and weighting based on hospital needs to help with drug selection for the hospital formularies.
Thyroid medications and patient adherence: understanding prescription patterns and factors influencing treatment compliance
Authors: Poojary Bhavya , Wilson Merlin Maria , Jose Riya , Sam Sona P , George Ann Elizabeth 
Published: January 2024

Thyroid problems are common in India affecting around 42 million people. Early diagnosis and therapy play an important role in managing this endocrine disorder. Hypothyroidism and hyperthyroidism are the most common thyroid disorders and are treated with thyroid hormone replacement therapy and antithyroid drugs. However, medication adherence, side effects, and misunderstanding of the importance of medication lead to inconsistent intake. This study aimed to evaluate the pattern of prescribing and adherence to thyroid medication. This cross-sectional study was conducted over 6 months in a tertiary care hospital, involving 188 patients with thyroid disorders. Data was collected using a validated form and medication adherence rationing scale. The collected data, including MARS scores, were entered into Microsoft Excel and analyzed using IBM SPSS Version 25. Quantitative data were analyzed using the mean and standard deviation, while categorical data were summarized using frequencies and percentages. The Chi-square test was used to evaluate associations, with a significance level of p < 0.05. In our study, 163 participants diagnosed with hypothyroidism exhibited a notable adherence rate of 89.57%. The 25 hyperthyroid patients showed strong adherence to the recommended drugs, with those provided methimazole having the highest adherence rate (52.0%). No statistically significant connections were found when examining the variables affecting drug adherence. Levothyroxine and methimazole were the preferred medications for managing hypothyroidism and hyperthyroidism, respectively. A high adherence rate among patients indicates heightened awareness and understanding of their condition, as well as consistent adherence to the medication schedule. These findings emphasize the importance of early diagnosis, appropriate prescription patterns, and patient adherence in effectively managing thyroid disorders.
Síndrome cardiorrenal tipo 4 en paciente revascularizado percutáneamente
Authors: Pedrosa Algarín Marina , Martínez Carreño Erika , Cueto Chaparro Manuel , Almanza Páez Carlos , Vega Rodríguez Moisés 
Published: January 2024

Introducción: el síndrome cardiorrenal es una patología dada por la disfunción en la interdependencia de estos órganos por interacciones bidireccionales (agudas o crónicas), los cuales pueden afectar indistintamente la función renal o ventricular.
Objetivo: presentar y justificar la enfermedad renal crónica como desencadenante de cuadros congestivos por falla cardiaca de novo.
Presentación del caso: se reporta el caso de un paciente masculino de 69 años revascularizado percutáneamente hace tres años con múltiples comorbilidades que ingresa en el contexto de una falla cardiaca de novo, secundaria a su enfermedad renal crónica estadio V de base, en manejo con hemodiálisis y en quien se descartó enfermedad coronaria aguda y miocardiopatía infiltrativa. Se logró estabilizar la injuria renal y cardiaca dando egreso y continuando manejo ambulatorio de sus patologías, al llevar un control adecuado de las mismas con Nefrología y Cardiología.
Discusión y conclusión: la enfermedad cardiovascular generada por antecedentes renales tiene una gran repercusión en la función ventricular izquierda, causando hipertrofia, lo que lleva a una congestión con posterior sobrecarga debido a la caída del filtrado glomerular y que resulta en la disminución de la fracción de eyección.
La enfermedad renal crónica predispone a alteraciones en la función cardiaca, lo que aumenta el riesgo cardiovascular.
Evaluation of Physical Characteristics, Carbohydrate Content, and Sensory Preference of Suwar-suwir Caisim
Authors: Tejasari Tejasari , Safitri Lailya 
Published: January 2024

Suwar-suwir is Jember-Indonesia’s traditional snack made from cassava fermented (tape) and sugar which give rises to very sweet flavor and sticky texture, causing consumer disfavor. This study aimed to determine the amount of mustard caisim powder added for fixing suwar-suwir texture, color and its sensory preference. This complete randomized controlled design tested effects of 6 level mustard caisim powder addition (Control=K=0, SF1=17, SF2=25, SF3=33, SF4=42, SF5=50%) toward suwar-suwir quality and sensory preference. The result showed that the addition significantly (P<0.05) affected physical properties and carbohydrate level (Fc>Ftab), and sensory liking preference (X2c >X2tab). The higher the addition of mustard caisim powder, the lower the texture value, the lower the color, the higher carbohydrate content. Suwar-suwir produced with 17% mustard caisim powder (SF1) has the best color, flavor, and overall performance. This suwar-suwir SF1 having more crunchy dense (163.2±4.80 mm/g.s,) more light green (29.59±0.29), high carbohydrate level (81.59±0.96%), high dietary fiber-TDF (20.8±0.01%), water soluble dietary fiber- SDF (6.29±0.002%) that lower than water insoluble dietary fiber - IDF (14.2± 0.01%). Based on the result analysis, it is recommend that the level addition of mustard caisim powder for improving suwar-suwir quality and image is 17 % from wet blend dough weight which produced suwar-suwir caisim SF1.
Dextrose Equivalent (DE) Variation and Maltodextrin Concentration Effects in Yoghurt Powder Characteristics Using Foam-mat Drying
Authors: Eris Fitria Riany , Pamela Vega Yoesepa , Kusumasari Septariawulan , Febriansah Muhammad Rizal , Riyanto Rifqi Ahmad 
Published: January 2024

Lactic Acid Bacteria (LAB) in yoghurt is a probiotic bacteria which potentially improves intestinal health. Yoghurt has a high moisture content. Thus, storing it at low temperatures can maintain the stability of microbes in the yoghurt. Yoghurt stored in the refrigerator has a maximum shelf life of 10 days. Yoghurt powder is one of the alternative solutions to prolong the shelf life. This study used a randomized design of factorial groups with variations of dextrose equivalent (DE) values of 10-12 and 18-20, as well as variations of maltodextrin concentrations of 10, 15, and 20%. The study aimed to determine the DE value and maltodextrin concentration which can produce the best quality synbiotic yoghurt powder. The quality of this synbiotic yoghurt was assessed by the highest yield, lowest water content, highest solubility, highest water absorption, highest acidic titrated total, highest total of lactic acid bacteria, and highest organoleptic. The study obtained that the DE value of maltodextrin affected the total LAB. Meanwhile, the concentration of maltodextrin affected the yield, moisture content, solubility, acidic titrated total, and total of LAB. The interaction between the DE value and the concentration of maltodextrin did not affect all the parameters of this study.
Effect of Soaking Time on the Physicochemical Characteristics, Antioxidant Activity, and Glycemic Index of Parboiled Local Cultivar Black Rice from West Sumatra
Authors: Nasution Saidah Nauli , Nazir Novizar , Wellyalia Wellyalina , Azmi Aida Firdaus Muhammad Nurul , Hariry Amelia 
Published: January 2024

Black rice, originating from Sariak Alahan Tigo in Solok Regency, is one of the indigenous rice varieties found in West Sumatra. Black rice is a cereal variety that has a low glycemic index and is rich in phytochemical substances called anthocyanins. These compounds act as antioxidants, helping to prevent diabetes and preserve the cardiovascular system. The procedure of parboiling involves varying the period of grain soaking in order to maximize the health advantages of anthocyanins found in black rice. The study utilized a completely randomized design (CRD) consisting of 5 treatments and 3 duplicates. The treatment protocol utilized in this experiment consisted of A (control), B (grain immersion for 2 hours), C (grain immersion for 3 hours), D (grain immersion for 4 hours), and E (grain immersion for 5 hours). The data acquired were evaluated using analysis of variance (ANOVA) and subsequently subjected to Duncan's Multiple Range (DNMRT) analysis at a significance level of 5%. The study findings indicate that the duration of grain soaking has a notable impact on various factors, including water content, starch levels, amylose and amylopectin levels, antioxidant activity, starch digestibility (in vitro), glycemic index values, taste, and texture. Nevertheless, the duration of grain soaking does not have any discernible impact on the physical hue, sensory hue, or fragrance of parboiled black rice. The treatment that is most favored according to the results of the sensory study is treatment D, which has a color rating of 3.86 (like), a fragrance rating of 3.91 (like), a taste rating of 3.91 (like), and a texture rating of 3.81 (like).
Diversity, Vegetation Structure, Estimated Biomass and Carbon Stock in The Site of Limboto Lake of Gorontalo Regency
Authors: Rahim Sukirman , Baderan Dewi Wahyuni K , Arfa Bella Saskia , Angio Melisnawati H , Hariri Muhammad Rifqi , Putri Dwinda Mariska 
Published: January 2024

The development of Limboto Lake Site as the pilot area of Gorontalo Geopark is one step in rescuing the lake. This research aims to analyzed the vegetation structure, estimate biomass, and assess the carbon stock value of the vegetatio at the Limboto Lake site. This study employed a purposive sampling method. Important Value Index, a measure used to evaluate plant vegetation structure, was calculated based on Realtive Density, Relative Dominance, and Relative Frequency values. Biomass estimation and carbon stock assessment were conducted using allometric equations. The study’s finding showed that the vegetation surrounding Soekarno's landing area exhibited the highest IVI (sawlogs) scores for Swietenia mahagoni tree at 82.86%, Leucaena leucocephala saplings at 79.56%, and Manihot esculenta seedlings at 46.33%. Leucaena leucocephala consistently achieved the highest IVI score within the Limboto Lake area with a score as high as 76.90%, followed by Leucaena leucocephala on the sapling level with a score as high as 70.03%, and Nauclea orientalis on the seedling level with a score as high as 53.06%. Swietenia mahagoni, Samanea saman, and Leucaena leucocephala are three species with stems that predominate at the sawlog level and sapling, and these stems have high carbon absorption values.
Formulasi Gel Antibakteri Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Menggunakan Hydroxy Propyl Methyl Cellulose(HPMC) dan Uji Aktivitas terhadap Staphylococcus aureus
Authors: Valentina Febriana Eka , Saryanti Dwi 
Published: January 2024

The content of flavonoids, alkaloids, and saponins in fragrant pandan leaves (Pandanus amaryllifolius Roxb.) can be antibacterial to inhibit the growth of microorganisms on the skin. The extract obtained from fragrant pandan leaves (DPW) is processed into a gel, with the consideration that the gel adheres well, does not block skin pores, is easily rinsed with water and has very good absorption. The purpose of this study was to determine the HPMC content as a gelling agent so as to obtain an antibacterial gel preparation of DPW extract with the best physical quality and antibacterial activity on Staphylococcus aureus (SA). The DPW ethanol 96% extract gel made from 2%, 3%, 4% HPMC was tested for the physical stability of the gel stored at room temperature for 21 days which included evaluation of organoleptic, homogeneity, degree of acidity, viscosity, spreadability, adhesion. Gel activity against SA was carried out using the well method. Antibacterial gel from DPW extract using 2% HPMC concentration has the best physical quality compared to DPW extract gel with other HPMC concentrations. Antibacterial gel from DPW extract with 2% HPMC concentration in gel form, dark green color, pandan aroma, homogeneous and uniform, pH 6 ± 0, pH is not harmful to skin, viscosity 325 ± 0 dPa.s, spreadability 7.5 gcm /s , adhesion 15.17 ± 0.00 seconds, antibacterial activity against SA with an inhibition zone of 27.26 ± 25.30 mm was classified as very strong. The result of preparations were stable for 21 days.
A Solution for Fermat’s Last Theorem Using Ramanujan-Nagell Equation
Authors: Seetharaman Palamadai N. 
Published: January 2024

Fermat’s Last Theorem states that it is impossible to find positive integers A, B, and C satisfying the equation:
An + Bn = Cn
where n is any integer > 2.
Taking the proofs of Fermat for the index n = 4, and Euler for n = 3, it is sufficient to prove the theorem for n = p, any prime > 3 [1].
We hypothesize that all r, s and t are non-zero integers in the equation:
rp + sp = tp
and establish contradiction.
Just to support the proof in the above equation, we have another equation:
x3 + y3 = z3
Without loss of generality, we assert that both x and y as non-zero integers; z3 is a non-zero integer; and z and z2 are irrational.
We create transformed equations to the above two equations through parameters, into which we have incorporated the Ramanujan - Nagell equation. Solving the transformed equations, we prove the theorem.