bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Selective Inhibitors of α‐Glucosidase for the Treatment of Type 2 Diabetes Mellitus
Authors: Khanchouch Takwa , Vallin Aurélie , Alali Urjwan , Benazza Mohammed , Abidi Rym , Bonnet Véronique 
Published: February 2024

AbstractType 2 diabetes mellitus is a metabolic dreadful disease caused by an uncontrolled glucose level in the bloodstream, particularly high after a meal. Inhibitors of glucosidases, involved in the digestion of carbohydrates, can regulate this post‐prandial increase in glucose concentration. The traditional drugs act as competitive inhibitors of both pancreatic α‐amylase and α‐glucosidases and this unselective inhibition is behind severe gastrointestinal side effects related to the concomitant inhibition of α‐amylase. We described herein some perglycosylated cyclodextrins as efficient and selective inhibitors of α‐glucosidase with low micromolar IC50 (3.64‐7.98 μM) compared to the acarbose (IC50 212 μM), clinically used for patients suffering from type 2 diabetes. On the other hand, they do not inhibit α‐amylase (IC50>500 μM). Structure/activity relationship rationalization suggests multiple interactions between the described inhibitors and α‐glucosidase, which support the existence of both active site and allosteric interactions.
Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
Authors: Rinaldi Sabina , Dossus Laure , Keski‐Rahkonen Pekka , Kiss Agneta , Navionis Anne‐Sophie , Biessy Carine , Travis Ruth , Weiderpass Elisabete , Romieu Isabelle , Eriksen Anne Kirstine , Tjonneland Anne , Kvaskoff Marina , Canonico Marianne , Truong Thérèse , Katzke Verena , Kaaks Rudolf , Catalano Alberto , Panico Salvatore , Masala Giovanna , Tumino Rosario , Lukic Marko , Olsen Karina Standahl , Zamora‐Ros Raul , Santiuste Carmen , Aizpurua Atxega Amaia , Guevara Marcela , Rodriguez‐Barranco Miguel , Sandstrom Maria , Hennings Joakim , Almquist Martin , Aglago Kouassivi Elom , Christakoudi Sofia , Gunter Marc , Franceschi Silvia 
Published: February 2024

AbstractThyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow‐up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri‐menopausal women, 111 in post‐menopausal women, and 70 in men) and 706 cancer‐free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre‐menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96–2.92, ptrend = .06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96–3.30, ptrend = .06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28–1.05, ptrend = .07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post‐menopausal women and men but may suggest an involvement of altered sex steroid production in pre‐menopausal women.
Diagnosis and resolution of an enigmatic calcified pelvic mass post‐hysterectomy: A case report
Authors: Ota Kuniaki , Asai Satoshi , Takagi Shun , Kikuchi Mahomi , Miyazaki Kotaro , Saiki Naohiko , Tajima Hiroto , Nagase Masanori , Asada Hironori , Ota Yoshiaki , Takahashi Toshifumi 
Published: February 2024

SynopsisA 73‐year‐old woman with a history of hysterectomy presented with pelvic calcified lesions. Imaging led to laparoscopic surgery, revealing a calcified fibroid after subtotal hysterectomy.
The impact of digital health technologies on the quality of service delivery: A pre and post assessment of the healthcare consumer's experiences in Ghana
Authors: Preko Mansah , Budu Joseph 
Published: February 2024

AbstractThis study takes into account the pre and post experiences of the healthcare consumer in a developing country context regarding the use of digital technologies in receiving healthcare services. The study proposes a conceptual framework which suggests that the digitalization of healthcare services may present both tangible and intangible outcomes to the healthcare consumer. Underpinned by the SERVQUAL model, this study adopts a qualitative approach to explore the pre and post‐digitalization experiences of healthcare consumers in Ghana. Findings reveal that seven out of the nine dimensions used in the study's assessment gave positive outcomes on the consumers' post‐digitalization experiences, despite claims of the social inequalities that characterize developing countries (DCs) like Ghana. The study further reveals how the patient‐centered eHealth concept which is gaining considerable attention in Information Systems (IS) healthcare research, has not been fully adopted in some DC contexts. This study presents both practical and theoretical implications for all relevant stakeholders within the healthcare ecosystem.
Evaluation of two physical guidance procedures in the treatment of pediatric feeding disorder
Authors: Rubio Emily Kate , McMahon Meara X. H. , Volkert Valerie M. 
Published: February 2024

AbstractChildren with pediatric feeding disorder may refuse to consume an adequate variety and/or volume of food to maintain expected growth. They can consume food but may actively or passively refuse, resulting in escape or avoidance of eating. Behavioral interventions like positive reinforcement with escape extinction can increase consumption. However, sometimes these interventions are insufficient, especially in treating passive refusal. In these cases, physical guidance may be used to prompt an open mouth to deposit food. Research indicates open‐mouth prompts are effective and rated as acceptable. This study replicated an existing physical guidance procedure, the finger prompt, and compared its efficacy and acceptability with that of a spoon prompt. This study extended research by defining and measuring passive refusal as a dependent variable and assessing social validity among different stakeholders and times. Both prompts were effective in treating food refusal, and caregivers rated the finger prompt as more preferred.
Implementation of a portable diffraction phase microscope for digital histopathology
Authors: Aimakov Nurbolat , Min Eunjung , Ban Sungbea , Lee Sangjin , Bae Jung Kweon , You Joon S. , Jung Woonggyu 
Published: February 2024

AbstractQuantitative phase imaging (QPI) has a significant advantage in histopathology as it helps in differentiating biological tissue structures and cells without the need for staining. To make this capability more accessible, it is crucial to develop compact and portable systems. In this study, we introduce a portable diffraction phase microscopy (DPM) system that allows the acquisition of phase map images from various organs in mice using a low‐NA objective lens. Our findings indicate that the cell and tissue structures observed in portable DPM images are similar to those seen in conventional histology microscope images. We confirmed that the developed system's performance is comparable to the benchtop DPM system. Additionally, we investigate the potential utility of digital histopathology by applying deep learning technology to create virtual staining of DPM images.
Combination ofin silicoand cell culture strategies to predict biomaterial performance: Effects of sintering temperature on the biological properties of hydroxyapatite
Authors: de Almeida Gerson S. , Ferreira Marcel R. , Fernandes Célio C. , de Biagi Carlos A. O. , Silva Wilson Araújo , Rangel Elidiane C. , Lisboa‐Filho Paulo N. , Zambuzzi Willian F. 
Published: February 2024

AbstractAdvances in methodologies to evaluate biomaterials brought an explosive growth of data, ensuing computational challenges to better analyzing them and allowing for high‐throughput profiling of biological systems cost‐efficiently. In this sense, we have applied bioinformatics tools to better understand the biological effect of different sintering temperatures of hydroxyapatite (abbreviated HA; at 1100, 1150, and 1250°C) on osteoblast performance. To do, we have better analyzed an earlier deposited study, in which the access code is E‐MTAB‐7219, which the authors have explored different in silico tools on this purpose. In this study, differential gene expression analyses were performed using the gene set variation analysis (GSVA) algorithm from the transcriptomes respecting the thermal changes of HA, which were validated using exclusively in vitro strategies. Furthermore, in silico approaches elected biomarkers during cell behavior in response to different sintering temperatures of HA, and it was further validated using cell culture and qPCR technologies. Altogether, the combination of those strategies shows the capacity of sintered HA at 1250°C to present a better performance in organizing an adequate microenvironment favoring bone regeneration, angiogenesis and material resorption stimulus once it has promoted higher involvement of genes such as CDK2, CDK4 (biomarkers of cell proliferation), p15, Osterix gene (related with osteogenic differentiation), RANKL (related with osteoclastogenesis), VEGF gene (related with angiogenesis), and HIF1α (related with hypoxia microenvironment). Altogether, the combination of in silico and cell culture strategies shows the capacity of sintered HA at 1250°C in guaranteeing osteoblast differentiation and it can be related in organizing an adequate microenvironment favoring bone regeneration, angiogenesis, and material resorption stimulus.
Synthesis of palladium nanoparticles utilizing biotemplates and investigation of their synergistic catalytic performance
Authors: Xie Wei , Chen Miaomiao , Wu Chao 
Published: February 2024

AbstractBACKGROUNDPalladium nanoparticles can act as a shuttle to accelerate the extracellular electron transfer (EET) by exoelectrogens. Through the EET process, microorganisms drive the redox cycle of many substances. The palladium nanoparticle has a variety of catalytic activities and activities can be significantly improved by combining with the active effects of microorganisms.RESULTSIn this study, Staphylococcus saprophyticus JJ‐1 was utilized as a biological template carrier to synthesize palladium nanoparticles that were immobilized on the bacterial surface. The morphology and composition of palladium were characterized by various techniques including transmission electron microscopy, energy‐dispersive X‐ray spectroscopy, X‐ray diffraction, X‐ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. Furthermore, the hydrogenation activity of the synthesized Pd was tested at room temperature and atmospheric pressure using methyl orange as a model pollutant. Electrochemical characterization was carried out by cyclic voltammetry and potentiostatic measurements. The research demonstrated that palladium nanoparticles acted as both electronic mediators and catalysts in the dye reduction process, while S. saprophyticus JJ‐1 contributed to stabilizing nanoparticles and electrochemical activity. The synergistic effect between these two components significantly enhances MO degradation efficiency.CONCLUSIONThis study presented an energy‐saving method to synthesize an integrated catalyst based on the synergistic interaction between biomass and nanoparticles, offering a novel approach for developing environmentally friendly, cost‐effective, and efficient integrated catalysts. © 2024 Society of Chemical Industry (SCI).
Artificial intelligence: ChatGPT as a disruptive didactic strategy in dental education
Authors: Saravia‐Rojas Miguel Ángel , Camarena‐Fonseca Alexandra Rosy , León‐Manco Roberto , Geng‐Vivanco Rocio 
Published: February 2024

AbstractPurposeTo evaluate the influence of ChatGPT on academic tasks performed by undergraduate dental students.MethodFifty‐five participants completed scientific writing assignments. First, ChatGPT was utilized; subsequently, a conventional method involving the search of scientific articles was employed. Each task was preceded by a 30‐min training session. The assignments were reviewed by professors, and an anonymous questionnaire was administered to the students regarding the usefulness of ChatGPT. Data were analyzed by Mann–Whitney U‐test.ResultsFinal scores and scores for the criteria of utilization of evidence, evaluation of arguments, and generation of alternatives achieved higher values through the traditional method than with ChatGPT (p = 0.019, 0.042, 0.017, and <0.001, respectively). No differences were found between the two methods for the remaining criteria (p > 0.05). A total of 64.29% of the students found ChatGPT useful, 33.33% found it very useful, and 3.38% not very useful. Regarding its application in further academic activities, 54.76% considered it useful, 40.48% found it very useful, and 4.76% not very useful. A total of 61.90% of the participants indicated that ChatGPT contributed to over 25% of their productivity, while 11.9% perceived it contributed to less than 15%. Concerning the relevance of having known ChatGPT for academic tasks, 50% found it opportune, 45.24% found it very opportune, 2.38% were unsure, and the same percentage thought it is inopportune. All students provided positive feedback.ConclusionDental students highly valued the experience of using ChatGPT for academic tasks. Nonetheless, the traditional method of searching for scientific articles yield higher scores.
Preventative and therapeutic potential of nutrition for inflammatory bowel diseases: A narrative review
Authors: Limketkai Berkeley N. , Rau Sameeha , Fasulo Christina 
Published: February 2024

AbstractDiet strongly shapes the gut microbiome and metabolome, which in turn influence intestinal inflammation in patients with inflammatory bowel disease (IBD). Separate from inflammation and malnutrition, diet's direct interactions with the gastrointestinal system can also provoke or attenuate a host of nonspecific gastrointestinal symptoms. Given these multifaceted effects of diet on inflammation and symptoms, nutrition has been investigated for its potential roles in the prevention and treatment of IBD. This review presents epidemiological, observational cohort, and clinical trial evidence that underlie our current understanding of nutrition for prevention and treatment of IBD.
Rapid indirect separation of glutamine enantiomers by micellar electrokinetic chromatography. Analysis of dietary supplements
Authors: Salido‐Fortuna Sandra , Ruano‐Culebras Paloma , Marina María Luisa , Castro‐Puyana María 
Published: February 2024

Glutamine is the most abundant free proteinogenic α‐amino acid. It is naturally produced in the organism and acts as a precursor for the synthesis of different biologically important molecules (such as proteins or nucleotides). However, under stressful conditions, the organism is unable to produce it in enough amounts to function properly. Thus, glutamine (Gln)‐based supplements have become increasingly popular over the last decade. Since legal regulations establish that amino acid‐based dietary supplements must contain only the L‐enantiomer and not the racemate, adequate chiral methodologies are required to achieve their quality control. In this work, an analytical methodology based on the use of micellar electrokinetic chromatography is proposed for the rapid enantiomeric determination of DL‐Gln in dietary supplements. Using (+)‐1‐(9‐fluorenyl)‐ethyl chloroformate as a derivatizing agent and ammonium perfluorooctanoate as separation medium, the Gln diastereoisomers formed under optimal conditions were separated in 8 min with a resolution of 2.8. The analytical characteristics of the method were evaluated in terms of linearity, precision, accuracy, and limits of detection/quantitation, and they were found appropriate for the analysis of L‐Gln‐based dietary supplements.
Associations between different forms of intimate partner violence and posttraumatic stress among women who use drugs and alcohol in Kyrgyzstan
Authors: Jiwatram‐Negron Tina , Meinhart Melissa , Ward Malorie , Michalopoulos Lynn , Zhan Qihao , Nikitin Danil , Gilbert Louisa 
Published: February 2024

AbstractSurvivors of intimate partner violence (IPV) have an increased risk of experiencing posttraumatic stress, and the subsequently associated symptoms can vary by form of IPV exposure (i.e., physical, sexual, or psychological IPV). Related research among socially marginalized populations, however, is limited, including among women who use and misuse substances. Drawing on baseline data from a pilot study conducted among 213 women in Kyrgyzstan who reported using drugs or engaging in hazardous alcohol use, we examined the associations between different forms of IPV and severe posttraumatic stress symptoms (PTSS). The vast majority of participants reported lifetime (93.9%, n = 200) and past 3‐month (65.3%, n = 139) IPV, and two thirds of participants (65.3%, n = 139) reported experiencing PTSS in the prior month. Multivariable logistic regression analyses indicated statistically significant associations between only some forms of IPV and PTSS, including physical IPV, adjusted odds ratio (aOR) = 3.24, 95% confidence interval (CI) [1.15, 9.14], and injurious IPV, aOR = 2.71, 95% CI [1.10, 6.65]. Additionally, experiencing any form of IPV was associated with 4.95 higher odds of reporting PTSS, 95% CI [1.16, 21.15]; no other results were significant. These results not only underscore the need for future research on the mechanisms that might explain the unique associations between different forms of IPV and posttraumatic stress, but also highlight an urgent need for trauma‐informed mental health and psychosocial support interventions for women who use drugs and alcohol.
Gender Disparities in Academic Otolaryngology
Authors: Ladlie Beth L. , Case Hannah F. , Perisetla Priyanka , Austin Andrew W. , Craver Emily C. , Engelberg‐Cook Erica , Rutt Amy L. 
Published: February 2024

ObjectiveThe aim was to evaluate representation of women in otolaryngology by examining authorship of research publications and presentations, awards, research grants, leadership, and membership in related organizations.MethodsAuthorship was reviewed from articles published in three otolaryngology journals from 2000 through 2021 to assess the frequency and percentages of female and combination of male and female gender authorship. Gender was evaluated for poster and scientific abstract presentations from 2007 to 2021. Gender representation was reviewed for institutional and society leadership positions, award, and grant recipients in the American Laryngological Society (ALA). Changes in the frequency of female and combination of male and female gender authorship over time were examined with Cochran‐Armitage test for trend.ResultsA total of 16,921 articles, 1,017 presentations, 480 leadership positions, 129 president positions, and 1,137 awards and grants were studied. Women were first authors in 4,153 (24.9%) and last authors in 2,935 (17.8%) published articles for which gender could be determined. Women were first authors in 372 (37.4%) presentations and last authors in 199 (20.2%). Most presentations had a combination of male and female presentation authorship (630, 68%). Women held 69 (14.4%) leadership positions. Of the award and grant recipients, 327 (28.8%) were female. Significant trends were observed for increasing female representation (first authorship publications increased 69.9% from 2000 to 2020, first authorship presentations increased 73.9% from 2007 to 2013, p < 0.001; leadership and awards from 3% to 18% representation, p = 0.02).ConclusionThe proportion of women receiving awards and holding leadership positions is increasing. Efforts that promote gender diversity may further increase representation of women in otolaryngology literature and among the grant and award winners.Level of EvidenceNA Laryngoscope, 134:2144–2152, 2024
On the commuting probability of π$\pi$‐elements in finite groups
Authors: Martínez Juan 
Published: February 2024

AbstractLet be a finite group, be a set of primes, and be the smallest prime in . In this work, we prove that possesses a normal and abelian Hall ‐subgroup if and only if the probability that two random ‐elements of commute is larger than . We also prove that if is a ‐element not lying in , then the proportion of ‐elements commuting with is at most .
High efficiency holographic impedance metasurface for dual circular polarized OAM waves
Authors: Huang Hui‐Fen , Xiang Zi‐Yi 
Published: February 2024

AbstractThis paper proposes a high aperture efficiency (AE) small size tensor holographic impedance metasurface (THIMS), which has the ability to create circular polarized (CP) high purity orbital angular momentum (OAM) multi‐beams with flexibly independent control of the individual beam direction, polarization and OAM mode. The tensor unit cell is a cross‐slotted circular patch. We design a THIMS at 14.6 GHz for dual CP OAM beams: Beam‐I (LHCP, l = 1, θ1 = 30°, φ1 = 0°), Beam‐II (RHCP, l = −1, θ2 = 30°, φ2 = 180°). The developed tensor dual CP THIMS has the following advantages: high purity in xoy plane at z = 9.73 λ (λ wavelength, measured purity 88.4% for Beam‐I, and 93.5% for Beam‐II), high AE 25.1%, and small size 5.986 λ × 5.986 λ × 0.0618 λ. The calculated, simulated and measured results agree well. The generated dual CP OAM beams have potential applications for high‐capacity wireless communication, radar high resolution imaging, and rotation velocity measurement.
Ultrasonographic evaluation of ulnar nerve morphology in patients with ulnar nerve instability
Authors: Ahmadli Narmin , Akgun Kenan , Terlemez Rana , Misirlioglu Tugce Ozekli , Palamar Deniz 
Published: February 2024

AbstractIntroduction/AimsUlnar nerve instability (UNI) in the retroepicondylar groove is described as nerve subluxation or dislocation. In this study, considering that instability may cause chronic ulnar nerve damage by increasing the friction risk, we aimed to examine the effects of UNI on nerve morphology ultrasonographically.MethodsAsymptomatic patients with clinical suspicion of UNI were referred for further clinical and ultrasonographic examination. Based on ulnar nerve mobility on ultrasound, the patients were first divided into two groups: stable and unstable. The unstable group was further divided into two subgroups: subluxation and dislocation. The cross‐sectional area (CSA) of the nerve was measured in three regions relative to the medial epicondyle (ME).ResultsIn the ultrasonographic evaluation, UNI was identified in 59.1% (52) of the 88 elbows. UNI was bilateral in 50% (22) of the 44 patients. Mean CSA was not significantly different between groups. A statistically significant difference in ulnar nerve mobility was found between the group with CSA of <10 versus ≥10 mm2 (p = .027). Nerve instability was found in 85.7% of elbows with an ulnar nerve CSA value of ≥10 mm2 at the ME level.DiscussionThe probability of developing neuropathy in patients with UNI may be higher than in those with normal nerve mobility. Further prospective studies are required to elucidate whether asymptomatic individuals with UNI and increased CSA may be at risk for developing symptomatic ulnar neuropathy at the elbow.