bluuebunny/crossref_metadata_2025_split huggingface dataset:
The selection of the initial drug in the treatment of severe psoriasis
Authors: Zhukova O. V. , Artemyeva S. I. 
Published: September 2023

Psoriasis is an immune-mediated skin disease associated with an increased risk of comorbidities and a significant negative impact on the quality of life of patients. In moderate and severe forms of psoriasis it is necessary to assign systemic therapies. The newest paradigm of treatment has become possible as a result of constant deepening of knowledge of pathophysiology of the disease. A clear mechanism is finally known down to the molecular level as to which cytokines are involved in the pathogenesis of psoriatic disease. Interleukin (IL)-23 mediates the activation of the Th17 pathway, which is hypothesised to be a major contributor to he inflammation observed in psoriasis, as proven, among other things, by the high efficacy of IL-23 inhibitor biological agents. It is obvious that great progress has been made in the field of genetically engineered biological therapy for psoriasis, both in terms of safety and efficacy. However, the issue of selecting a biologic drug individually in each patient is pressing, including in the case of initiation of the first genetically engineered biological drug in bionaive patients. The article provides an overview of the key points in the process of biological drug selection depending on the present comorbidities, and also describes a clinical case of successful therapy of a bionaive patient with concomitant depressive disorder in the anamnesis against the backdrop of a severe course of psoriasis. Successful use of IL-23 inhibitor (Guselkumab) allowed to achieve persistent remission and improve the quality of life, which in turn had a positive effect on the patient’s comorbid profile. This observation allows us to conclude that the use of guselkumab as the first biological agent is a rather effective, safe and promising option in the treatment of severe psoriasis.
Effect of an anti-aging care product on the main morphofunctional skin parameters
Authors: Kholupova L. S. , Surkichin S. I. , Ponomareva D. M. 
Published: September 2023

Introduction. Cosmetic care occupies an important place in the correction of visible involutive skin changes. Existing high-tech methods of preserving and delivering active ingredients to the skin allow us to create unique ampoule concentrate, in particular Anti-Aging Reviving Elixir from LaCabine, the main components of which are snow algae powder, probiotics and chamomile extract.Aim. To study the effect of Anti-Aging Reviving Elixir by LaCabine on the main morphofunctional skin parameters (hydration, elasticity, pigmentation, fine wrinkles, sensitivity) and evaluate the organoleptic properties and ease of use. e for 28 days. Using the Aramo ASW device, the following skin parameters were determined before and after the course: hydration, elasticity, pigmentation, fine wrinkles, sensitivity. For a general visual assessment, photography was carried out in the aesthetics mode with the FotoFinder device.Results. The organoleptic properties, adverse events, as well as the ease of use of the properties were evaluated by an oral survey of each patient. The results showed that the course use of Anti-Aging Reviving Elixir by LaCabine leads to enhanced appearance of the skin, improved morphofunctional parameters, in particular hydration and elasticity, and reduced fine wrinkle severity. Due to ease of use and good organoleptic properties, the product is characterised by a high level of compliance.Conclusion. Anti-Aging Reviving Elixir by LaCabine can be recommended for home care as part of anti-aging skin care programs.
Value-Added Zobo Drink with Date Juice
Authors: Ojileh Prince C. , Okechukwu Queency N. 
Published: September 2023

Hibiscus sabdariffa L., also known as edible roselle, belongs to the Malvaceae family and is native to West Africa. In Nigeria, its dried petals are processed by boiling and filtration into a non-alcoholic beverage called Zobo. Commercial Zobo often includes artificial sweeteners that improve its taste. As a result, local food science needs new formulations with natural and health-beneficial sweeteners. The research objective was to produce a Zobo drink with different blends of date fruit juice as a natural sweetener, as well as evaluate its proximate, physicochemical, and sensory properties.
The control Zobo drink (Zcon) involved an artificial sweetener. The ratios of Zobo to date juice were 90:10 (ZD10), 80:20 (ZD20), 70:30 (ZD30), 60:40 (ZD40), and 50:50 (ZD50). The samples underwent proximate and physicochemical analyses, as well as a sensory assessment on a nine-point hedonic scale.
The physicochemical analysis showed that Sample ZD50 with the 50:50 ratio had the highest pH (3.5) and sugar content (9.5°Bx) while the control sample had the lowest pH (2.5) and sugar content (0.9°Bx), with all samples showing significant (p ≥ 0.05) differences. The proximate analysis also showed a wide range of results (p ≥ 0.05). The control sample demonstrated the highest moisture content (97.0%) whereas Sample ZD50 had the highest ash and lipid content of 0.8 and 4.8%, respectively. Sample ZD50 also had the highest protein (2.23%) and crude fiber content (2.49%). Sample ZD40 with the 60:40 ratio had the highest carbohydrate content. In terms of mouthfeel and taste (p ≥ 0.05), the control sample demonstrated the highest scores while the lowest score belonged to Sample ZD10 with the lowest proportion of date juice. The best results for general acceptance belonged to the control, followed by ZD40 (60:40) and ZD50 (50:50).
Date juice proved to be an effective sweetener that improved the nutritional profile of Zobo. However, the sensory analysis showed that consumers preferred the control sample with the artificial sweetener.
Effect of Dry Aging on Beef Muscle Proteins
Authors: Gurinovich Galina , Patrakova Irina , Khrenov Vladislav , Patshina Marina , Shevchenko Antonina 
Published: September 2023

Meat is an inherent part of human diet. Its quality develops at different stages of production, storage, and processing. In this respect, the stage of aging is especially important. This technology makes it possible to regulate biochemical processes in meat raw materials. Long-term dry aging is a promising method that presupposes conditions that limit the growth of microorganisms. The transformations in the protein component are an important but understudied aspect of meat quality formation during dry aging.
The research featured Hereford beef carcasses of Siberian breeding. The samples were isolated from the inner part of bone spinal-lumbar cuts after 21, 35, and 42 days of dry aging under the following conditions: 0–1°C, 74–75% relative humidity, 0.5 m/s air velocity. The samples were subjected to dry aging after 24 h at 4°C. The fractional composition of proteins was controlled by vertical electrophoresis in a Mini-Protean Tetra System chamber. The amino acid composition was defined by high-performance liquid chromatography in a Shimadzu LC-20 Prominence liquid chromatograph with a Shimadzu SPD20MA diode-matrix detector and a Kromasil C-18 separation column. The protein digestibility was measured by sequential exposure to pepsin-trypsin proteinase system under simulated gastric digestion.
Long-time dry aging triggered proteolysis under the action of endogenous enzymes. The electropherogram analysis showed that the proteolytic changes in high-molecular myofibrillar proteins of high-quality beef became more pronounced after a longer maturation period. The distribution of protein fractions by dry aging stages indicated a different rate of degradation of contractile, regulatory, and cytoskeletal proteins. As a result, the structural integrity of muscle fibers degraded, the meat grew tender, and the proteins became more available to digestive enzymes. The amino acid and protein digestibility analyses in vitro demonstrated an increase in the nutritional value of beef and the availability of proteins to the action of proteinases after 42 days of dry aging.
Long-term dry aging of high-quality beef increased the digestibility of muscle proteins as a result of proteolysis that accompanied the accumulation of low-molecular fractions. According to the amino acid analysis, the optimal result was most pronounced on day 42 as proven by the moderate oxidative changes in proteins.
Optimizing the Production of Polysaccharides from Cyanobacterium sp. IPPAS B-1200
Authors: Sukhikh Stanislav , Budenkova Ekaterina , Boychenko Yulia-Danae , Anokhova Veronika , Dolganyuk Vyacheslav , Kashirskich Egor 
Published: September 2023

Cyanobacterium sp. IPPAS B-1200 is a cyanobacteria strain that belongs to the rare genus Cyanobacterium, family Cyanobacteriaceae fam. nov. Studies devoted to the isolation of secondary metabolites from this strain concentrate mostly on the fatty acid composition while the issue of isolating and identifying exopolysaccharides remains understudied. However, polysaccharides from cyanobacteria are of scientific and economic interest in the framework of biotechnology, medicine, pharmacology, etc. The research objective was to study the effect of the physicochemical conditions of cultivation and the composition of the cultural medium on exopolysaccharide production.
Cyanobacterium sp. B-1200 were grown under 7500 ± 50 lux (12 h light/12 h dark). The dry cell weight was determined by gravimetry and a calibration plot that illustrated the dependence of the biomass amount on the degree of absorption at a wavelength of 750 nm. The amount of polysaccharides in the culture liquid was assessed by the Anthrone-sulphate method. The extraction was carried out by alcohol precipitation. The method of ultrasonic dispersion was used to destroy the cell walls of cyanobacteria.
The experimental study revealed the optimal parameters for the extraction and purification of exopolysaccharides from the culture medium. Removal of sodium bicarbonate from the medium and a 300%-increase in its concentration raised the yield of polysaccharides. The optimal value of active acidity for the synthesis of polysaccharides was pH = 6 while the optimal temperature for their accumulation was 35°C. The largest amount of biomass was obtained at 25°C. Intense white illumination contributed to the greatest release of exopolysaccharides into the culture medium; red-white illumination affected the morphology of cyanobacteria cells. During the extraction, the concentration, temperature, and nature of the extractant proved to be the most important factors. For example, isopropanol produced the highest yield while butanol triggered the least effective response.
The optimal extraction and purification modes for polysaccharides were as follows. For ultrasonic processing, the best results were obtained at a power of 20 W after 5 min. For freeze drying, the rational parameters were 8 h at –15°C.
AN ASSESSMENT OF TRAFFIC CONGESTION IN TAMAN SRI SERDANG, SELANGOR, MALAYSIA
Authors: Fahmi Afiq Haikal , Sahrir Syazwani , Nik Ab Rahim Nik Nor Rahimah 
Published: September 2023

The issue of traffic congestion has emerged as a significant and multifaceted challenge in numerous cities worldwide, encompassing substantial economic and environmental implications. Numerous experts have proposed that the foremost measure to address the congestion issue is to identify the characteristics of traffic congestion. This study aimed to assess the traffic congestion in urban road networks. Thus, the main methodological approach for conducting the study was the traffic volume study in Taman Sri Serdang, which was observed to examine the traffic flow during weekdays and weekends to examine the traffic flow patterns. Accordingly, conducting a traffic volume and Level of Service (LOS) analysis is necessary to enhance accessibility and road capacity. A comparison of the traffic trends and LOS during weekdays and weekends was also discussed. The findings concerning peak-hour traffic patterns are highlighted, and the conclusions are derived regarding urban traffic flow patterns.
Latvijas preses korespondenti Spānijas pilsoņu karā: Oto Zeltiņa un Georga Timuškas piemērs
Authors: Bikše Ginta Ieva 
Published: September 2023

Rakstā izvērtēta divu laikraksta “Jaunākās Ziņas” preses korespondentu – Oto Zeltiņa un Georga Timuškas – sniegtā informācija un darbība Spānijas pilsoņu karā laika posmā no 1936. gada septembra līdz 1937. gada oktobrim. Aplūkoti faktori, kas ietekmēja iespēju sniegt objektīvas reportāžas par norisēm Spānijas pilsoņu karā, – propaganda, cenzūra un korespondentu ideoloģiskā pārliecība. Vienlaikus pievērsta uzmanība Latvijas preses korespondentu darba apstākļiem, raksturojot ikdienu un izaicinājumus Spānijas pilsoņu kara kontekstā.
Care Bundles and Peripheral Arterial Catheters: A Scoping Review
Authors: Reynolds Heather , Gowardman John , Woods Christine 
Published: September 2023

Highlights
What we know about the topic: Recommendations for the use of vascular access care bundles to reduce infection are followed for different devices. The risk of arterial catheter-related infection is comparable with short-term, non-cuffed central venous catheters. There are practice concerns for clinicians inserting and caring for peripheral arterial catheters.
What this paper adds: The selected studies had a theme of decreased infection after using bundled strategies for all devices. Few studies addressed use of bundles for care of peripheral arterial catheters. High quality research should be performed about using care bundles for insertion and care of arterial catheters.

Abstract

Introduction:
A scoping review of the literature was performed.

Aims/Objectives:
To find information on the use of care bundles for care of arterial, central, and peripherally inserted venous catheters.

Methods:
Data was extracted by 2 independent researchers using standardized methodology

Results:
Results of 84 studies included 2 (2.4%) randomized controlled trials, 38 (45.2%) observational studies, 29 (34.5%) quality projects, and 15 (17.9%) reviews. Populations had more adults than pediatric patients. All studies had the most prominent theme of decreased infection in all devices after using bundle strategies.

Discussion and Conclusions:
The mapping of available evidence strongly supports the use of care bundles to reduce infection in the care of all intravascular devices. However, deficiencies regarding practice concerns about insertion and care of arterial catheters highlight areas for future research with the aim to eliminate the gap in the evidence of studies of care bundles for peripheral arterial catheters.
The Effectiveness of Shared Decision-making for Diabetes Prevention: 24- and 36-Month Results From the Prediabetes Informed Decision and Education (PRIDE) Trial
Authors: Duru O. Kenrik , Mangione Carol M. , Turk Norman , Chon Janet , Fu Jeffery , Cheng Grace , Cheng Felicia , Moss Amanda , Frosch Dominick , Jeffers Kia Skrine , Castellon-Lopez Yelba , Tseng Chi-Hong , Maranon Richard , Norris Keith C. , Moin Tannaz 
Published: September 2023

OBJECTIVE
We conducted a cluster-randomized, shared decision-making (SDM) trial offering lifestyle change, metformin, or both options, to adults at risk for diabetes in a primary care network (n = 20 practices).

RESEARCH DESIGN AND METHODS
We used propensity score matching to identify control patients and used electronic health record data to compare weight loss at 24 and 36 months of follow-up and diabetes incidence at 36 months of follow-up.

RESULTS
In adjusted post hoc analyses, SDM participants (n = 489) maintained modestly greater 24-month weight loss of −3.1 lb and 36-month weight loss of −2.7 lb versus controls (n = 1,430, both comparisons P &lt; 0.001). SDM participants who chose both lifestyle change and metformin sustained weight loss at 36 months of −4.1 lb (P &lt; 0.001 vs. controls). We found no differences in incident diabetes (15% of SDM participants, 14% of control participants; P = 0.64).

CONCLUSIONS
This is one of the first studies to demonstrate weight loss maintenance up to 36 months after diabetes prevention SDM.
Conversa com o Professor Humberto Bortolossi
Authors: Nóbriga Jorge Costa , Carrazedo Dantas Sérgio , Bortolossi Humberto 
Published: September 2023

O Professor Humberto Bortolossi é Licenciado em Matemática pela UEM, mestre em Matemática pelo IMPA e doutor em Matemática pela PUC-Rio. É professor Associado I da Universidade Federal Fluminense. Ele é uma das grandes referências no Brasil quando o assunto é GeoGebra. Foi o primeiro tradutor do GeoGebra para o português do Brasil, ajudando muito a divulgar e implementar o uso do software no País. Certamente, também deveria ser um autor convidado para escrever um artigo para essa edição. Todavia, no momento que a revista começou a ser produzida, o Humberto não estava com condições de escrever. Dessa forma, optamos por fazer uma conversa online com ele e transcrevê-la.
Development of an artificial intelligence system for the forecasting of infectious diseases
Authors: Kuzin A. A. , Glushakov R. I. , Parfenov S. A. , Sapozhnikov K. V. , Lazarev A. A. 
Published: September 2023

Aim. Here, we provided an overview of artificial intelligence (AI) approaches for developing a system for prediction of infectious diseases and designed a respective step-by-step protocol.Materials and Methods. Literature search in PubMed and Google Scholar and PubMed.Key Points. Infectious diseases impose a heavy burden on a healthcare, demanding the development of novel and efficient approaches to prevention as well as sensitive and specific diagnostic tests. Evolution of data science have led to the emergence of promising artificial intelligence (AI) algorithms and tools for the forecasting of infectious diseases. Employing machine learning algorithms, AI systems can rapidly analyze a large amount of data, extract specific disease patterns, and screen for the most efficient AI instruments in relation to specific tasks, thus contributing to prevention, diagnostics, and treatment of infectious diseases in the context of personalized medicine. Importantly, such AI-based systems can determine specific human motor patterns from videos and/or photographs in order to assist physicians in primary diagnosis. Integration of AI tools into the existing healthcare algorithms can be especially useful for public health.
Dietary consumption of lipids as a potential risk factor for non-communicable diseases in Western Siberia
Authors: Turchaninov D. V. , Shirlina N. G. , Viktorova I. A. , Stasenko V. L. , Chubarova A. D. , Vilms E. A. 
Published: September 2023

Aim. To assess the profile of lipid consumption in the population of Omsk Region, located in Western Siberia.Materials and Methods. During 2019-2020, we have performed a cross-sectional survey in the adult population of the Omsk region (n = 441, age 18-83 years). Questionnaires included an information regarding the food intake, nutritional status, and health status. In addition, we measured body mass index, waist circumference and waist-to-hip ratio. Among the parameters, we evaluated average daily consumption of energy, fats, cholesterol, saturated, monounsaturated, and polyunsaturated fatty acids, phospholipids, linoleic acid, alpha-linolenic acid, and arachidonic acid. In addition, we assessed the ratio of omega-6 to omega-3 fatty acids in the diet, specific weight of vegetable fats, and the energy quotas of individual nutrients.Results. In the population of Western Siberia, we found insufficient intake of alpha-linolenic acid (69.6 ± 2.2% population), arachidonic acid (55.3 ± 2.4%), polyunsaturated fatty acids (44.4 ± 2.4%), and phospholipids (37.6 ± 2.3%), as well as excessive consumption of cholesterol (74.1 ± 2.1%), total fats (61.9 ± 2.3%), saturated fatty acids (47.8 ± 2.4%), monounsaturated fatty acids (37.6 ± 2.3%), energy (34.7 ± 2.1%), and linoleic acid (31.1 ± 2.2%). In all groups of respondents, we registered high values of the omega-6/omega-3 ratio. The proportion of respondents with adequate consumption of energy and nutrients did not exceed 59.2 ± 2.3%.Conclusion. The diet of the adult population in Western Siberia was characterized by dysbalanced lipid consumption (more than 60% of the population). We documented an insufficient consumption of polyunsaturated fatty acids and phospholipids in combination with excessive consumption of products containing cholesterol, saturated fatty acids, monounsaturated fatty acids, and linoleic acid.
Single or multiple arterial grafting to design a coronary bypass: a retrospective study
Authors: Frolov A. V. , Zagorodnikov N. I. , Tarasov R. S. , Grigoriev E. V. 
Published: September 2023

Aim. To compare the efficiency of single arterial grafting (SAG) and multiple arterial grafting (MAG) at coronary artery bypass graft (CABG) surgery in the long term.Material and Methods. To assess the angiographic outcomes, we evaluated the patency of 323 bypasses at 102 angiograms obtained during coronary angiography performed > 10 years post-CABG surgery.Results. Out of 323 analyzed bypasses, 230 (71.2%) showed physiological functioning, whereas stenosis, occlusions, and other coronary artery alterations were found in 93 (28.8%) bypasses. The most common cause for the failure of anastomoses was competitive flow (most frequently registered in the anastomoses between left internal thoracic artery and left anterior descending artery, left internal thoracic artery and diagonal branches of left anterior descending artery, right internal thoracic artery and left anterior descending artery, and between right internal thoracic artery and right coronary artery), poor distal bed (most frequently revealed in the anastomosis between left internal thoracic artery and obtuse marginal artery, saphenous vein and diagonal branches of left anterior descending artery, saphenous vein and obtuse marginal artery, and between saphenous vein and right coronary artery), progression of atherosclerosis in combination with poor distal bed (most frequently detected in the anastomosis between right internal thoracic artery and obtuse marginal artery), and combination of poor distal bed, competitive flow, and graft degeneration (most frequently found in the anastomoses between radial artery and obtuse marginal artery and between radial artery and right coronary artery). In 5 (5.4%) cases, the cause of coronary bypass dysfunction was unclear.Conclusion. The main causes for the coronary bypass failure included competitive flow (in case with multiple arterial grafting) and poor distal bed (in case with single arterial grafting).
An Analysis of the Structure of the Beekeeping Chain in the Territories of the State of Rio Grande do Norte (RN)
Authors: Da Silva Wellington Gaspar Ferreira , Da Silva Edinal Salustiano , Siqueira Elisabete Stradiotto , Siqueira Filho Valdemar , Nepomuceno Luciana Holanda , Nobre Liana Holanda Nepomuceno , Bispo Danielle de Araújo , De Brito Filho Arrilton Carlos 
Published: September 2023

Purpose: The present research aims to analyze the organizational structure of the honey chain in the state of Rio Grande do Norte.

Method/design/approach: Semi-structured interviews were conducted with eight representative subjects from the beekeeping chain in the municipalities of Rio Grande do Norte. A descriptive qualitative approach was adopted to analyze the organizational relationships within the chain.

Results and conclusion: The results highlight challenges in regulating the honey production chain, suggesting improvements in governance through collaborative development of regulations. Additionally, it emphasizes the importance of associations and producer cooperatives in strengthening beekeeping, adding value, and overcoming commercial challenges. Certification was deemed more relevant for the chain links involved in honey processing and distribution.

Research implications: The study reveals that the various actors involved in the honey production chain in Rio Grande do Norte have significant disagreements regarding the interpretation of the legislation governing the production of this product.

Originality/value: The research contributes to understanding the organizational structure of the honey chain in Rio Grande do Norte, providing development strategies in the apiculture sector.