bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of EMT related prognostic signature for kidney renal clear cell carcinoma, through integrating bulk and single-cell gene expression profiles
Authors: Huang Qi , Li Feiyu , Liu Li , Xu Rui , Yang Tao , Ma Xiaoyun , Zhang Hongmei , Zhou Yan , Shao Yongxiang , Wang Qiaofeng , Xi Haifeng , Ding Yancai 
Published: November 2023

Introduction: Kidney renal clear cell carcinoma (KIRC), as a main type of malignant kidney cancers, has a poor prognosis. Epithelial-mesenchymal transformation (EMT) exerts indispensable role in tumor progression and metastasis, including in KIRC. This study aimed to mine more EMT related details and build prognostic signature for KIRC.Methods: The KIRC scRNA-seq data and bulk data were downloaded from GEO and TCGA databases, respectively. The cell composition in KIRC was calculated using CIBERSORT. Univariate Cox regression analysis and LASSO Cox regression analysis were combined to determine the prognostic genes. Gene set variation analysis and cell-cell communication analysis were conducted to obtain more functional information. Additionally, functional analyses were conducted to determine the biological roles of si-LGALS1 in vitro.Results: We totally identified 2,249 significant differentially expressed genes (DEGs) in KIRC samples, meanwhile a significant distinct expression pattern was found in KIRC, involving Epithelial Mesenchymal Transition pathway. Among all cell types, significantly higher proportion of epithelial cells were observed in KIRC, and 289 DEGs were identified in epithelial cells. After cross analysis of all DEGs and 970 EMT related genes, SPARC, TMSB10, LGALS1, and VEGFA were optimal to build prognostic model. Our EMT related showed good predictive performance in KIRC. Remarkably, si-LGALS1 could inhibit migration and invasion ability of KIRC cells, which might be involved in suppressing EMT process.Conclusion: A novel powerful EMT related prognostic signature was built for KIRC patients, based on SPARC, TMSB10, LGALS1, and VEGFA. Of which, si-LGALS1 could inhibit migration and invasion ability of KIRC cells, which might be involved in suppressing EMT process.
Functional physical training improves fitness and cognitive development in 4~5 years old children
Authors: Hao Lei , Fan Yongzhao , Zhang Xiaojuan , Rong Xiangjiang , Sun Youping , Liu Kun 
Published: November 2023

BackgroundDevelopment of physical and cognitive function is very critical in 4~5 years children. It has been addressed in this research if the 18 weeks of specific functional training with or without cognitive training can be effective on improving fitness and cognitive development in 4~5 years preschool children.MethodsA total of 126 preschool children in the 4~5 age range were selected as participants and randomly assigned to one of four groups: the control group (C), the functional physical training group (P), the cognitive training group (CT), and the functional physical training combined with cognitive training group (PCT).ResultsThe results revealed significant pre/post differences in body height and weight among all four groups of children. Furthermore, there was no significant difference in physical fitness between the C group and the CT group after the intervention. However, the children in the P group and the PCT group showed significant improvements in three indicators including standing long jump, continuous jump, and 10-meter shuttle running. Additionally, the children in P group, CT group, and the PCT group demonstrated significant improvement in simple reaction time, attention, and spatial memory. No significant cognitive improvement was found in C group.ConclusionFunctional physical training with or without cognitive intervention can promote both physical fitness and cognitive development in children aged 4~5 years. Cognitive training alone can significantly improve cognitive function but not physical. Therefore, functional physical training can be used alone to improve the physical and cognitive abilities for aged 4~5 years old children.
Evaluation of the Italian version of the elderly mobility scale in older hospitalized patients
Authors: Nicolai Moreno , Casoni Elisa , Bertino Emanuela , David Letizia , Polverigiani Chiara , Mallucci Federica , Fioretti Paola , Leonzi Sara , Bevilacqua Roberta , Barbarossa Federico , Maranesi Elvira , Baccini Marco , Barboni Ilaria , Riccardi Giovanni R. 
Published: November 2023

IntroductionReliable and valid assessment tools are needed to evaluate and predict physical function in older hospitalized patients. The aim of this study is to develop the Italian version of the Elderly Mobility Scale (I-EMS) and to evaluate its validity and inter-rater reliability for use with geriatric inpatients.MethodsThe study consists of two phases: (i) translation, where EMS version 2 was translated into Italian by two teams, each comprising 2 bilingual physiotherapists; translations were back translated by 2 native English speakers, and a committee of 2 physiotherapists and 1 physician refined the initial I-EMS version, which was pilot-tested for clarity in a group of ten experienced geriatric physiotherapists; (ii) an observational study assessed I-EMS metrics (reliability, validity) in older Italian inpatients at IRCCS INRCA (Ancona, Italy) between September 2022 and April 2023.ResultsNo statistically significant differences were found between the scores of individual items and the total score assigned by different raters. The ICC for total I-EMS was 0.951, SEM was 1.10 and MDC95 was 3.06. The absolute agreement and weighted kappa for individual items ranged 80.32–100% and 8.2–1, respectively. The validity of I-EMS was supported by a significant (p &lt; 0.05) correlation with the Barthel Index (r = 0.827 and 0.834 for the I-EMS administered by rater A and rater B, respectively).ConclusionI-EMS showed good internal consistency and inter-rater reliability, and confirmed construct validity with respect to BI. Therefore, it can safely be used as an assessment tool for hospitalized Italian geriatric patients.Clinical trial registration[ClinicalTrials.gov], [NCT05806242].
ANALISIS MUTU BISKUIT MORINGNA SEBAGAI ALTERNATIF ANEMIA PADA REMAJA PUTRI
Authors: Pratiwi Aulya , Fitria Mona , Sulaeman Agus , Agung Fred , Moviana Yenny 
Published: November 2023

Penyebab utama dari anemia gizi besi pada wanita yaitu kurangnya asupan makanan zat besi (Fe). Asupan zat besi dapat diperoleh dari makanan berupa biskuit. Tepung kelor dan tepung kacang hijau yang ditambahkan sebagai bahan biskuit dapat dijadikan makanan selingan tinggi zat besi dalam upaya meningkatkan asupan zat besi pada remaja putri. Penelitian ini bertujuan untuk mengetahui pengaruh formulasi tepung kelor dan tepung kacang hijau terhadap sifat organoleptik dan kadar zat besi. Penenlitian ini merupakan penelitian ekspreimental dengan formulasi perbandingan F1 75% : 25%, F2 50% : 50% dan F3 25% : 75%. Uji organoleptik dilakukan oleh 30 orang agak terlatih, lalu hasil terbaik diuji kadar zat besi dengan metode ICP-OES. Analisis data menggunakan Uji Kruskal Wallis, dilanjutkan dengan metode Uji Mann Whitney. Biskuit yang memilki skor tertinggi adalah formulasi F1 dengan perbandingan tepung kelor dan tepung kacang hijau 75% : 25%.Satu takaran saji 60 gram dan dapat memenuhi 24% dari kebutuhan zat besi. Hasil uji stastistik ditemukan nilai (p (0,000) < α (0,05)) yang berarti ada pengaruh formulasi tepung kelor dan tepung kacang hijau terhadap rasa biskuit, dan ada pengaruh pada aspek rasa, aroma, dan tekstur biskuit. Penelitian ini dapat dilanjutkan dengan memperbaiki tesktur pada produk untuk lebih meningkatkan daya terima serta melakukan penelitian kepada sasaran.
PEMBERDAYAAN KADER DALAM MENGENALI GANGGUAN JIWA DAN PENANGANAN KECEMASAN DI WILAYAH KERJA PUSKESMAS BABAKAN SARI BANDUNG
Authors: Z Desmaniarti , Kusmiati Sri , Erlina Lina , Sasmita Anah 
Published: November 2023

The status quo of development of science and technology has made people face various complex life changes that have led to a tendency for mental disorders. Basic Health Research (2018) confirms that the number of people with a mental health conditions in the world has reached 450 million. In Indonesia, the number of people with a mental health conditions has reached 1.7 per million to 7 per million, while in West Java, it reached 72 thousand people in 2018 (Riskesdas, 2018). The visit of patients with mental disorders is relatively high in West Java, namely the Babakan Sari Health Center, Bandung City. However, the services performed by healthcare workers are limited to inside the building. Posyandu activities by health cadres only serve toddlers and geriatric related to physical health problems.
In contrast, in reality, especially with the Covid-19 outbreak, many people are experiencing mental problems, especially anxiety. Based on this, mental health services are needed in the community as a first step to be carried out by increasing the knowledge and skills of cadres about early recognition of mental disorders and handling anxiety so that it does not progress to severe mental disorders. This community service program is carried out for health cadres in the working area of ​​the Babakan Sari Health Center, Bandung City, with the output in the form of booklets and videos that cadres and families can use, as well as increased knowledge and skills of health cadres about early recognition of mental disorders and anxiety management. The method used is cadre training on early recognition of mental disorders and how to deal with anxiety. The result of this community service is an increase in the knowledge and skills of health cadres in early recognition of mental disorders and treatment of anxiety and being able to convey them to families, reducing the level of family anxiety.
Correlating Deep Learning-Based Automated Reference Kidney Histomorphometry with Patient Demographics and Creatinine
Authors: Lucarelli Nicholas , Ginley Brandon , Zee Jarcy , Mimar Sayat , Paul Anindya S. , Jain Sanjay , Han Seung Seok , Rodrigues Luis , Ozrazgat-Baslanti Tezcan , Wong Michelle L. , Nadkarni Girish , Clapp William L. , Jen Kuang-Yu , Sarder Pinaki 
Published: November 2023

Key Points

The authors leverage the unique benefits of panoptic segmentation to perform the largest ever quantitation of reference kidney morphometry.Kidney features vary with age and sex; and glomeruli size may intricately link to creatinine, defying prior notions.

Background
Reference histomorphometric data of healthy human kidneys are largely lacking because of laborious quantitation requirements. Correlating histomorphometric features with clinical parameters through machine learning approaches can provide valuable information about natural population variance. To this end, we leveraged deep learning (DL), computational image analysis, and feature analysis to associate the relationship of histomorphometry with patient age, sex, serum creatinine (SCr), and eGFR in a multinational set of reference kidney tissue sections.

Methods
A panoptic segmentation neural network was developed and used to segment viable and sclerotic glomeruli, cortical and medullary interstitia, tubules, and arteries/arterioles in the digitized images of 79 periodic acid–Schiff-stained human nephrectomy sections showing minimal pathologic changes. Simple morphometrics (e.g., area, radius, density) were quantified from the segmented classes. Regression analysis aided in determining the association of histomorphometric parameters with age, sex, SCr, and eGFR.

Results
Our DL model achieved high segmentation performance for all test compartments. The size and density of glomeruli, tubules, and arteries/arterioles varied significantly among healthy humans, with potentially large differences between geographically diverse patients. Glomerular size was significantly correlated with SCr and eGFR. Slight, albeit significant, differences in renal vasculature were observed between sexes. Glomerulosclerosis percentage increased, and cortical density of arteries/arterioles decreased, as a function of increasing age.

Conclusions
Using DL, we automated precise measurements of kidney histomorphometric features. In the reference kidney tissue, several histomorphometric features demonstrated significant correlation to patient demographics, SCr, and eGFR. DL tools can increase the efficiency and rigor of histomorphometric analysis.
Main directions of formation of tax policy of the organization in the conditions of introduction of ESG-technology
Authors: Zyukov V. V. 
Published: November 2023

Aim. To consider the main problems of transformation of tax policy of the organization under the influence of ESG-regulations in the conditions of global development of integrated reporting and to establish the dependence of the level of sustainable economic development of the company, growth of its rating on the incorporation of tax policy elements into the indicators of financial and non-financial reporting.Objectives. To study the concept and significance of tax policy for the formation of qualitatively new integrated reporting; to determine the role of tax policy in improving the investment attractiveness and competitiveness of the company; to establish the impact of ESG-concept on the construction of tax policy and financial results of the company; to study the current state of the regulatory and legal framework of the Russian Federation (RF), which regulates the introduction of ESG-technology in the composition of local acts of the company.Methods. The study used private-scientific and general scientific methods, including methods of historical approach, systematization of empirical and theoretical research; analyzed the current legal and regulatory framework in the field of development and implementation of ESG-elements and identified the leading directions of tax policy formation in the conditions of ESG-rating.Results. The recommendations developed by state regulators on the formation of integrated reporting and ESG-rating of sustainable development do not reflect the tax component. In this regard, the methodology proposed by the author is designed to contribute to the formation of, in fact, an innovative complex local normative legal act, tax policy in general, which takes into account the specifics of the introduction (embedding) of ESG-components.Conclusions. Creation of a comprehensive science-based architecture of tax policy within the framework of ESG-technology will contribute to the achievement of sustainable development goals of the company. In particular, it will improve the quality of integrated reports, increase investment attractiveness, strengthen the organization’s position in ESG-ratings and reduce tax risks.
Theoretical aspects of using marketplaces in business promotion and export activities
Authors: Kulakov M. I. 
Published: November 2023

Aim. The purpose of the study is to analyze the main aspects of the use of marketplaces for the development of export activities of various business entities in our country, as well as to identify promising directions for improving such activities in modern conditions.Objectives. Definition of the essence of the concept of “marketplaces”; research of their role in the development of the system of trade relations in our country; analysis of the significance of marketplaces in the development of the system of promotion and export of modern companies.Methods. Both general scientific methods (analysis, synthesis, comparison, induction, deduction, etc.) in their totality and a group of special scientific methods were used in the preparation of the research. The latter include statistical analysis, analysis of dynamics, monographic analysis, etc.Results. Within the framework of modern practice of organizing the activities of various business entities, considerable attention today is paid to the issues of the most effective development of electronic commerce. This is due to the fact that it is at the expense of e-commerce that significant opportunities for increasing sales volume and, consequently, net profit are formed. In the long term, the development of electronic commerce allows to provide an almost complete “transition to a new format of work” of entrepreneurs, as well as to significantly reduce the volume of transaction costs due to the opportunities provided by modern companies involved in the functioning of electronic commerce.Conclusions. Today, in order to develop the activities of many trading companies, considerable attention should be paid to the practice of using the services and opportunities of various marketplaces as part of the promotion and development of export activities. This is due to the fact that such sites can provide significant opportunities for further development of trade activities. The above-mentioned opportunities to improve the practice of promotion and export activities should be taken into account both in the development of cooperation with online trading platforms and in the process of forming strategies for the development of marketplaces suppliers.
On the channels of “resource curse of the financial sector”
Authors: Yakovleva I. I. 
Published: November 2023

Aim. To identify the channels of the “resource curse of the financial sector”.Objectives. Systematization of the main approaches to describing the relationship between the state of the financial sector and resource dependence; classification of the identified channels of the “resource curse of the financial sector”.Methods. This article is based on the analysis and systematization of existing empirical and theoretical studies in the field of “resource curse of the financial sector” and related areas. The author used the methods of synthesis, generalization, classification and system analysis.Results. The description of possible channels of resource dependence influence on financial development has been carried out. The channels of “resource curse”, investment and savings, “Dutch disease”, volatility, human and social capital, “interest groups”, institutional channels are considered. The identified channels of the “resource curse of the financial sector” (or channels of the influence of resource dependence on the state of the financial sector) include a different set of chains of cause-effect relations. Some channels (the “resource curse” channel, channels related to the “Dutch disease”, etc.) involve explanations of the “resource curse” affecting the processes of economic growth and the resource curse hypothesis itself. Such channels are classified as specific. Depending on the nature of the impact of resource endowment on the state of the financial sector, three groups of channels are identified: “resource curse”, “conditional resource curse” and “resource blessing”.Conclusions. The hypothesis of “resource curse of the financial sector” can be considered as an element of a comprehensive approach to analyzing the peculiarities of the functioning of the economy under conditions of resource dependence. One of the formulations of this hypothesis assumes a relatively lower level of financial development, at which structural changes occur in the financial sector of countries specializing in the production and export of natural resources. The nature of the channels identified allows us to argue that only under a certain set of conditions the “resource curse of the financial sector” can occur, in which the fact of resource dependence of the economy or its consequences is a constraint for the development of the financial sector. The introduced channels need empirical verification. The developed classification of channels of “resource curse of the financial sector” can serve as a starting point for such an analysis.
Incidental mortality of seabirds in pollock trawl fishery in the northwestern part of the Bering Sea
Authors: Artukhin Yu. B. , Korobov V. , Gluschenko Yu. N. 
Published: November 2023

Purpose of the work: Estimation of average annual number of seabirds that die as a result of lethal strikes with fishing gear in the specialized pollock trawl fishery by large-tonnage fleet in the West Bering Sea zone.Methods used: The article is based on materials collected by ornithologists on large freezer trawlers in the summer and autumn periods in 2020 and 2021. To record bird deaths we used inspection of warps, net sonar wire third cable, net trawl, codend during trawl retrieval and count of bird lethal collisions with fishing gear during observation sessions at all stages of fishing operations. The total mortality was estimated by extrapolating the mean catch-rates (number of dead birds per vessel day) to fishing efforts of large-tonnage fleet in the West Bering Sea zone in 2020 and 2021.Novelty: The annual average mortality of birds in large-scale trawling was determined for the first time for domestic fisheries and an expert assessment of its potential risk to populations of the catched species was carried outResults: The death of 203 birds was recorded during 139 vessel days. The total estimated mortality in fishing gear was 8,355 (CI 5259–11451) birds per year: 4,717 northern fulmars, 1,667 short-tailed shearwaters, 1,006 Laysan albatrosses, 822 black-legged kittiwakes, 48 slaty-backed gulls, 48 Vega gulls, and 47 red-legged kittiwakes. Comparison of these estimates with the global or regional number of birds suggests that mortality in fishing gear in 2020 and 2021 did not have a significant negative impact on the state of species (proportion of dead birds was 0.005–0.085% of their population estimates). Despite the regular presence of short-tailed albatrosses near trawlers in the Navarin area, no deaths in fishing gear were recorded.Practical significance: The results are necessary for the process of ecological certification of the specialized pollock trawl fishery in the West Bering Sea zone.
Reproduction, biometric patterns of pink salmon and effect of commercial fishery on the runs of the species on the south of the north-eastern coast of Sakhalin Island in 2021
Authors: Kirillova E. A. 
Published: November 2023

Purpose: to present up-to-date data on the dynamics of the spawning run, reproduction conditions and biometric characteristics of pink salmon in three reference watercourses in the southern part of the north-eastern coast of Sakhalin Island, as well as analysis of impact of commercial fishing on the spawning run and distribution of spawners within spawning grounds. Methods: common methods of ichthyological research were applied to collect and process field data. Data were synthesized in MS Excel, analysis and visualization were carried out in MS Excel and Statistica. Scientific novelty: results of monitoring of pink salmon in the southern part of the north-eastern coast of Sakhalin are presented. Despite the intensive commercial fishery in this area, there are no other data on the dynamics of pink salmon runs, density of breeders on spawning grounds, and biometric characteristics of spawners, except for those presented in this paper. Result: data on the timing of spawning migration, distribution of pink salmon within spawning grounds and degree of occupation of spawning grounds, temporal structure of spawning run; bio-metric characteristics of pink salmon are presented. Assessment of the influence of commercial fishing on the dynamics of spawning run and distribution of pink salmon within spawning grounds is discussed. Practical relevance: the presented data is an integral part of information supply of fishery research of the most widespread species of Pacific salmon - pink salmon, which forms the basis of salmon fishery in the Sakhalin Region. Also, the presented data is applicable for preparation of scientifically-based recommendations for optimizing the fishing pressure.