bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steric Bulk‐Dependent Photoresponse of Sulfonamide Azobenzene Ligand in Arene Ruthenium(II) Complexes
Authors: Long Jonathan , Retailleau Pascal , Xie Juan , Bogliotti Nicolas 
Published: December 2023

AbstractA series of sulfonamide azobenzenes bearing alkyl substituents of increasing steric bulk at the position ortho to the N=N bond and their corresponding chloro(hexamethylbenzene)ruthenium(II) complexes were synthesized. The latter bearing mono‐substituted ligands exhibited an exocyclic azo bond under the E configuration, and underwent reversible E→Z photoisomerization upon irradiation with visible light, followed by thermal Z→E back isomerization upon resting in the dark at 20 °C. In contrast, the corresponding 2,6‐dimethyl substituted azobenzene complex, while also exhibiting an exocyclic azo bond, was isolated as the Z‐isomer and underwent uncommon solvent dependent irreversible photodissociation of azobenzene ligand upon visible light irradiation. Valuable insights into the photophysical and structural properties of these complexes were gained by combination of computational and X‐ray diffraction studies.
Patient values and preferences regarding communicating risk versus benefit of benzodiazepine initiation: A cross‐sectional survey study
Authors: Chahal Karn , Glass Matthew , Falk Jamie , Singer Alexander , Leong Christine 
Published: December 2023

AbstractBackground and AimsCommunicating information about the risks and benefits of benzodiazepines so that it is meaningful to the patient has not been previously described. This study aims to determine patient preferences regarding information received before initiating a benzodiazepine.MethodsAn online survey was distributed through social media and advertisements to Canadians ≥18 years old over a 6‐month period (May–Oct 2022) to collect participant's rating of importance of statements and factors about the risk and benefits of benzodiazepines before initiating treatment using a 10‐point Likert‐type scale. Treatment preferences based on efficacy and risk information were also elicited. The survey was developed and pilot‐tested in collaboration with an advisory committee of individuals with lived and living experience with benzodiazepine use.ResultsThirty‐seven participants responded to the survey (mean age 30 years old, 81.1% identified as female). The majority of respondents had a history of anxiety (83.8%) or insomnia (32.4%), and 10 (27.0%) respondents had used a benzodiazepine. Patient counseling related to withdrawal symptoms of benzodiazepines, risk of harm in combination with other sedating agents, risk of physical and psychological dependence, and risk of effects on cognition were rated high in the importance of receiving this information before starting a benzodiazepine relative to efficacy endpoints, such as improvement in sleep parameters. When provided with information about the chance of efficacy and risk of harm, 100% would have selected cognitive behavioral therapy as the best treatment option. The most frequently reported source of medication information where patients have sought information was from the internet (25.0%), followed by doctors (21.9%) and pharmacists (18.8%).ConclusionsThis study identified patient important factors and statements viewed as important to communicate before initiating a benzodiazepine. The findings of this survey study will help inform decision‐making when considering treatment options for managing anxiety or insomnia.
Patient involvement in research within the Gynecological Cancer InterGroup: A call to action for a systematic approach: Results from a survey
Authors: Nohová Ivana , Andrews John , Votan Bénédicte , Miller Austin , Sehouli Jalid , Berger Regina 
Published: December 2023

AbstractBackground and AimsInvolving patients in research, not only as trial subjects, is not a newly established practice. Over the last two decades, patient roles have gradually expanded to become active research contributors, creating a more patient‐centered research landscape. Our survey has explored the scope of patient involvement within the Gynecologic Cancer InterGroup (GCIG), an International Gynecologic Cancer Research Consortium, and identified challenges in developing a systematic, meaningful and sustainable level of patient involvement.MethodsIn late 2019, the GCIG Harmonisation Operations Committee conducted an online survey across 26 national and/or international research cooperative groups, aiming to identify current patient involvement practices implemented by each group. Twelve questions were asked. The results have been generated to support a systematic strategic planning process to increase patient involvement into clinical research projects.ResultsMore than half of the 26 participating groups have either already involved (15, [58%]) or are planning (6, [23%]) to involve patients in their research activities. Gaining patient support in raising public awareness around clinical trials appears to be one of the most desired benefits (21, [81%]). Ten respondents managed to integrate patient involvement into their standard practice. When involving patients in research the groups mostly consider that patients bring added value to the study (19, [73%]), although only eight groups (40%) have a well‐organized process in doing so.ConclusionEven though patient involvement is considered a significant added value to clinical research, its application within GCIG groups is not considered on a regular basis and is predominantly limited to operational aspects of research activities. The lack of resources and expertize, as well as the missing well‐organized and structured process of some groups, combined with their ability to ensure process sustainability, are among the main factors affecting implementation and adoption of patient involvement within GCIG research activities.
Research progress of microglial surface receptors in perioperative neurocognitive disorders
Authors: Tang Chun‐Chun , Liu De‐Xing , Zhu Zhao‐Qiong 
Published: December 2023

AbstractPerioperative neurocognitive disorder (PND) is a common complication in the perioperative period, which not only prolongs the hospitalization of patients, increases the cost of treatment, but even increases the postoperative mortality of patients, bringing a heavy burden to families and society. Mechanism exploration involves anesthesia and surgery that lead to microglial activation, promote the synthesis and secretion of inflammatory factors, cause an inflammatory cascade, aggravate nerve cell damage, and lead to cognitive dysfunction. It is believed that microglia‐mediated neuroinflammatory responses play a vital role in the formation of PND. Microglia surface receptors are essential mediators for microglia to receive external stimuli, regulate microglial functional status, and carry out intercellular signal transmission. Various microglial surface receptors trigger neuroinflammation, damage neurons, and participate in the development and progression of PND by activating microglia. In this study, the roles of immunoglobulin receptors, chemokine receptors, purinergic receptors, and pattern recognition receptors in microglia surface receptors in PND were reviewed, to provide a reference for the mechanism research, prevention, and treatment of PND.
Estimating the ex ante adoption determinants of novel cropping systems with nonpecuniary benefits
Authors: Mooney Daniel F. , Barham Bradford L. 
Published: December 2023

AbstractLandowners who value the nonpecuniary benefits of novel cropping systems may be more likely to adopt those systems in response to new market opportunities. We examine ex ante adoption decisions for bioenergy crops in Wisconsin using stated preference data from nonoperator landowners. Bioenergy crops produce biomass, a private good, and may jointly contribute to civic or environmental public goods. We find that pecuniary and nonpecuniary benefits influence landowner decisions, but the effects differ by annual and perennial crop types. Landowners may trade pecuniary for nonpecuniary benefits when equating the marginal utility of land uses, resulting in lower willingness‐to‐accept values for adoption.
Interconception care during well‐child visits by family physicians in the United States: A cross‐sectional study
Authors: Kuroda Kaku , Morley Christopher P. , Bailey R. Eugene 
Published: November 2023

AbstractBackgroundInterconception care (ICC) by family physicians during well‐child visits (WCVs) has been broadly advocated in principle but has not been widely implemented. We aimed to investigate ICC at WCVs by family physicians at our facility, focusing on four maternal risk factors, including maternal tobacco use, maternal depression, contraception, and folic acid supplementation.MethodsMothers who visited WCVs with children up to the age of 24 months at our university‐affiliated clinic were screened for the four maternal risks. Brief interventions were provided to mothers with positive screening results. We investigated mothers at WCVs from December 1, 2020, to November 30, 2022. We performed descriptive and binary logistic regression analyses to determine the maternal demographic factors associated with positive screenings.ResultsOf 1143 WCVs, 205 mothers were evaluated. Screening was positive in the following rates: tobacco use 5.9%, depression 11.5%, contraception 73.6%, and folic acid supplementation 40.5%. Single marital status was associated with positive screening for smoking (odds ratio [OR] 8.689, p = 0.016) and maternal depression (OR 3.470, p = 0.035). Maternal education level lower than a high school diploma was associated with positive screening for folic acid intake (OR 4.975, p = 0.004).ConclusionsICC conducted during WCVs by family physicians offers valuable opportunities to identify maternal risk factors and address modifiable factors that can influence future birth outcomes. Single marital status and educational level less than a high school diploma were more potent risk factors for maternal behavior in ICC. More research is needed to assess the outcomes of the interventions.
Circulating tumor DNA for monitoring classic Hodgkin lymphoma patients: Correlation with FDG‐PET/CT
Authors: Fernández Sara , Cereceda Laura , Díaz Eva , Figueroa Sasha , Reguera Laura , Menéndez Victoria , Solórzano José L. , Montalbán Carlos , Estévez Mónica , García Juan F. 
Published: November 2023

AbstractThe value of circulating tumor DNA (ctDNA) as a biomarker of disease activity in classic Hodgkin lymphoma (cHL) patients has not yet been well established. By profiling primary tumors and ctDNA, we identified common variants between primary tumors and longitudinal plasma samples in most of the cases, confirming high spatial and temporal heterogeneity. Although ctDNA analyses mirrored HRS cell genetics overall, the prevalence of variants shows that none of them can be used as a single biomarker. Conversely, the estimation of hGE/mL, based on measures of total ctDNA, reflects disease activity and is almost perfectly correlated with standard parameters such as PET/CT that are associated with refractoriness.
Evaluation and comparison of impedance and amplitude changes in lesion index‐guided pulmonary vein isolation
Authors: Kaneko Yutaro , Naruse Yoshihisa , Narumi Taro , Sano Makoto , Urushida Tsuyoshi , Maekawa Yuichiro 
Published: December 2023

AbstractBackgroundThe lesion index (LSI) has been used to estimate lesion formation after radiofrequency catheter ablation. However, the impedance drop and decrease in bipolar amplitude of intracardiac electrograms, which are parameters that are traditionally used to predict effective ablation lesions, are not used to calculate LSI. Therefore, we aimed to investigate the association between LSI and traditional parameters.MethodsWe retrospectively investigated 1355 ablation points from 31 patients who underwent LSI‐guided pulmonary vein isolation (PVI) using TactiCath. All points were classified into 3 groups based on the impedance drop: (i) <10 Ω (n = 67), (ii) 10–20 Ω (n = 909), and (iii) >20 Ω (n = 379). The LSI targets were 4.5 for the posterior left atrium and 5.2 for the anterior left atrium. After excluding 583 points at which it was difficult to measure the amplitude, 772 ablation points during sinus rhythm were included in the analysis of bipolar amplitude.ResultsThe target LSI was achieved at 1177 points (86.9%). The median total impedance drop and amplitude just after ablation were 16.0 [13.0–20.0] Ω and 0.21 [0.14–0.30] mV, respectively. There were significant differences among the 3 groups in the impedance and amplitude before ablation, power, target LSI, final LSI, contact force, and interlesion distance. An impedance drop of >10 Ω or an amplitude reduction of >50% was achieved at 95% and 82% of the study points, respectively. There were no major complications at any of the ablation points.ConclusionLSI‐guided PVI seemed to be useful for making sufficient ablation lesions, as assessed by the conventional parameters of impedance and amplitude change.
Association between fat‐free mass and survival in critically ill patients with COVID‐19: A prospective cohort study
Authors: Lakenman Patty L. M. , van Marwijk Iris , van der Hoven Ben , van Bommel Jasper , Joosten Koen F. M. , Olieman Joanne F. 
Published: December 2023

AbstractBackgroundMost critically ill patients with COVID‐19 experience malnutrition and weight loss associated with negative clinical outcomes. Our primary aim was to assess body composition during acute and late phase of illness in these patients in relation to clinical outcome and secondary to tailored nutrition support.MethodsThis prospective cohort study included adult critically ill patients with COVID‐19. Body composition (fat‐free mass [FFM] [exposure of interest], fat mass [FM], skeletal muscle mass [SMM], and phase angle [PA]) was determined with multifrequency bioelectrical impedance analyses in the acute and late phase. Nutrition support data were collected simultaneously. Clinical outcome was defined as intensive care unit (ICU) survival (primary outcome) and 30–90 days thereafter, duration of mechanical ventilation, and length of ICU stay and length of hospital stay (LOS). Nonparametric tests and regression analyses were performed.ResultsWe included 70 patients (73% male, median age 60 years). Upon admission, median BMI was 30 kg/m2, 54% had obesity (BMI > 30 kg/m2). Median weight change during ICU stay was −3 kg: +3 kg FM and −6 kg FFM (−4 kg SMM). Body composition changed significantly (P < 0.001). Regarding clinical outcome, only low PA was associated with prolonged LOS (odds ratio = 0.83, 95% CI = 0.72–0.96; P = 0.015). Patients with optimal protein intake (>80%) during acute phase maintained significantly more FFM (2.7 kg, P = 0.047) in the late phase compared with patients who received <80%.ConclusionFFM decreased significantly during acute and late phase of illness, but we observed no association with ICU survival. Only low PA was associated with prolonged LOS. FFM wasting likely occurred because of disease severity and immobility.
Assessment of fruity aroma intensity in olive oils from different Spanish regions using a portable electronic nose
Authors: Bianchi Alessandro , Cano Marchal Pablo , Martínez Gila Diego M. , Mencarelli Fabio , Gámez García Javier 
Published: November 2023

AbstractBACKGROUNDThe organoleptic profile of an olive oil is a fundamental quality parameter obtained by human sensory panels. In this work, a portable electronic nose was employed to predict the fruity aroma intensity of 199 olive oil samples from different Spanish regions and cultivar varieties (‘Picual’, ‘Arbequina’, and ‘Cornicabra’), with special emphasis in testing the robustness of the predictions versus cultivar variety variability. The primary data given by the electronic nose were used to obtain two different feature vectors that were employed to fit ridge and lasso regressions models to two datasets: one consisting of all the samples and another just the cv. Picual samples.RESULTSThe results obtained showed mean average error (MAE) values below 0.88 in all cases, with an MAE of 0.67 for the ‘Picual’ model. These MAE values and the similarities in the model parameters fitted for the different data folds are in agreement with the results obtained in previous studies.CONCLUSIONThe large number of samples analyzed and the results obtained show the robustness of the approach and the applicability of the methods. Also, the results suggest that better performance can be obtained when specific models are fitted for particular cultivars. Overall, the proposed methods are capable of providing useful information for a fast screening of the fruity aroma intensity of olive oils. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Long‐term overall survival in patients undergoing liver resection for metastatic anal squamous cell carcinoma
Authors: Lo Winifred M. , Dogeas Epameinondas , Etherington Mark S. , Ferrone Cristina , Nebbia Martina , Cleary Sean , Pery Ron , Steel Jennifer L. , Tohme Samer T. , Geller David A. 
Published: November 2023

AbstractBackground and ObjectivesThere is limited research on management of metastatic anal canal squamous cell carcinoma (SCC) to the liver. This study aimed to describe outcomes for patients undergoing liver resection of anal SCC metastases.MethodsA multicenter, retrospective cohort study was conducted by three tertiary‐referral centers. Patients undergoing liver surgery between 2008 and 2022 were included. Cox regression analysis was performed to evaluate predictors of recurrence and survival and Kaplan–Meier analysis was performed for 1‐, 3‐, and 5‐year survival.ResultsTwenty‐one patients underwent liver resection and/or ablation. None were HIV positive and 24% had known HPV infection. 20/21(95%) patients had undergone Nigro protocol for management of the primary tumor with 12/21 (57%) patients experiencing complete response. 4/21 (19%) patients had synchronous liver metastases at time of diagnosis. Median tumor size was 5.0 cm and median tumor number was one. At analysis, 52% remained alive. Median overall survival was 32.2 months. 5‐year overall survival was 50%. Median recurrence‐free survival was 7.7 months and 5‐year recurrence‐free survival was 30%. Need for salvage abdominoperineal resection was negatively associated with recurrence‐free survival. The most common site of recurrence was the liver.ConclusionsLiver resection for metastatic anal SCC can be beneficial for appropriately selected patients.
Ocular Surface Adverse Events are not Associated with Dupilumab use in Nasal Polyp Treatment
Authors: Swisher Austin R. , Kshirsagar Rijul S. , Vu Priscilla Q. , Liang Jonathan 
Published: December 2023

ObjectivesOcular surface reactions (OSR) have been associated with dupilumab for atopic dermatitis (AD) treatment. However, the association of dupilumab‐associated OSR (DA‐OSR) for nasal polyps (CRSwNP) treatment has not been studied. We evaluated DA‐OSR for CRSwNP treatment using the FDA Adverse Event Reporting System (FAERS).MethodsFAERS was queried for any general ocular reactions (DA‐GOR) from 2019Q1 to 2022Q4. DA‐OSR were subcategorized from DA‐GOR and compared between treatment groups (CRSwNP, asthma, AD). Logistic regression was used to predict DA‐OSR. Disproportionality analysis (DPA) of DA‐OSR was performed using OpenVigil.ResultsThere were 60,198 total observations, of which 5344 were treated for CRSwNP. The prevalence of DA‐GOR and DA‐OSR was greatest for AD (15.3%, 7.8%), followed by CRSwNP (12.2%, 6.7%) and asthma (9.2%, 3.5%). The most commonly reported OSRs were dry eyes (35.9%), conjunctivitis (15.7%), and increased lacrimation (11.0%). The reported odds ratio (ROR) of CRSwNP‐treated DA‐OSR was 0.84 (0.73–0.97; p = 0.015), compared to 1.29 (1.20–1.40; p < 0.001) for AD and 0.66 (0.59–0.73; p < 0.001) for asthma. For CRSwNP treatment, the DA‐OSR ROR was 0.97 (0.90–1.03; p = 0.3) for men and 0.78 (0.73–0.83, p < 0.001) for older adults (age > 50). ROR in the DPA for DA‐OSR was 12.5 (12.2–12.8; p < 0.001) for any indication and 0.58 (0.53–0.64; p < 0.001) for CRSwNP treatment only.ConclusionsWhile there are limitations to FAERS, this study confirms the association between dupilumab and OSR for AD treatment, and does not support an association between dupilumab and OSR for CRSwNP treatment. Younger adults experience more DA‐OSR in CRSwNP treatment without a specific predilection for sex.Level of EvidenceIV Laryngoscope, 134:2602–2608, 2024
Predicting dimensional accuracy in 3D printed polydimethylsiloxane‐carbon nanotubes composites via machine learning
Authors: Raj Ratnesh , Mahato Satyajit , Moharana Annada Prasad , Dixit Amit Rai 
Published: December 2023

AbstractDirect ink writing (DIW) is a rapidly expanding additive manufacturing (AM) technique valued for its cost‐efficiency and material adaptability. While DIW offers substantial process flexibility, achieving precise manufacturing demands a thorough understanding of its printability parameters. Key process variables such as printing speed, nozzle‐bed gap, pulses for extrusion, and extrusion multiplier wield significant influence over the shape and dimensions of printed components. In this study, a machine learning model based on k‐nearest neighbors is employed to predict dimensional accuracy. The model is trained using measured width and thickness data from printed rings, with flow and printing‐speed tests defining parameter boundaries for printing. The final model demonstrates an accuracy of 81% and 74% for two PDMS‐CNT composite ink compositions. The principal components analysis underscores the pivotal roles of the extrusion factor and printing speed in achieving superior geometric fidelity. Additionally, retraction‐residual tests were conducted, revealing that the initial 10 seconds of extrusion hold critical importance as they can lead to distortions when traversing printed regions or perimeters, necessitating consideration in part design. To evaluate layer adhesion strength, a crucial aspect of AM, T‐peel tests were performed. Furthermore, rheological tests provided insights into extrudability, printable reinforcing percentages, shape retention, and yield stress.Highlights
Rheological tests yield insights into minimum reinforcing% and shape retention.
Developed k‐NN model predicts accuracy using measured printed rings' data.
PC analysis shows key roles of extrusion factor and print speed.
Retraction‐residual tests reveal initial 10 seconds are critical.
Model validation results show 83.45% and 77.95% accuracy, close to prediction.
Large‐scale spatiotemporal calculation of photovoltaic capacity factors using ray tracing: A case study in urban environments
Authors: Bredemeier Dennis , Schinke Carsten , Niepelt Raphael , Brendel Rolf 
Published: November 2023

AbstractPhotovoltaics (PVs) on building facades, either building‐integrated or building‐attached, offer a large energy yield potential especially in densely populated urban areas. Targeting this potential requires the availability of planning tools such as insolation forecasts. However, calculating the PV potential of facade surfaces in an urban environment is challenging. Complex time‐dependent shadowing and light reflections must be considered. In this contribution, we present fast ray tracing calculations for insolation forecasts in large urban environments using clustering of Sun positions into typical days. We use our approach to determine time resolved PV capacity factors for rooftops and facades in a wide variety of environments, which is particularly useful for energy system analyses. The advantage of our approach is that the determined capacity factors for one geographic location can be easily extended to larger geographic regions. In this contribution, we perform calculations in three exemplary environments and extend the results globally. Especially for facade surfaces, we find that there is a pronounced intra‐day and also seasonal distribution of PV potentials that strongly depends on the degree of latitude. The consideration of light reflections in our ray tracing approach causes an increase in calculated full load hours for facade surfaces between 10% and 25% for most geographical locations.