bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are degenerative findings detected on traction MR arthrography of the hip associated with failure of arthroscopic femoroacetabular impingement surgery?
Authors: Lerch Till D. , Nanavati Andreas K. , Heimann Alexander F. , Meier Malin K. , Steppacher Simon D. , Wagner Moritz , Brunner Alexander , Vavron Peter , Schmaranzer Ehrenfried , Schwab Joseph M. , Tannast Moritz , Schmaranzer Florian 
Published: November 2023

Abstract
Objectives
To identify preoperative degenerative features on traction MR arthrography associated with failure after arthroscopic femoroacetabular impingement (FAI) surgery.

Methods
Retrospective study including 102 patients (107 hips) undergoing traction magnetic resonance arthrography (MRA) of the hip at 1.5 T and subsequent hip arthroscopic FAI surgery performed (01/2016 to 02/2020) with complete follow-up. Clinical outcomes were assessed using the International Hip Outcome Tool (iHOT-12) score. Clinical endpoint for failure was defined as an iHOT-12 of < 60 points or conversion to total hip arthroplasty. MR images were assessed by two radiologists for presence of 9 degenerative lesions including osseous, chondrolabral/ligamentum teres lesions. Uni- and multivariate Cox regression analysis was performed to assess the association between MRI findings and failure of FAI surgery.

Results
Of the 107 hips, 27 hips (25%) met at least one endpoint at a mean 3.7 ± 0.9 years follow-up. Osteophytic changes of femur or acetabulum (hazard ratio [HR] 2.5–5.0), acetabular cysts (HR 3.4) and extensive cartilage (HR 5.1) and labral damage (HR 5.5) > 2 h on the clockface were univariate risk factors (all p < 0.05) for failure. Three risk factors for failure were identified in multivariate analysis: Acetabular cartilage damage > 2 h on the clockface (HR 3.2, p = 0.01), central femoral osteophyte (HR 3.1, p = 0.02), and femoral cartilage damage with ligamentum teres damage (HR 3.0, p = 0.04).

Conclusion
Joint damage detected by preoperative traction MRA is associated with failure 4 years following arthroscopic FAI surgery and yields promise in preoperative risk stratification.

Clinical relevance statement
Evaluation of negative predictors on preoperative traction MR arthrography holds the potential to improve risk stratification based on the already present joint degeneration ahead of FAI surgery.

Key Points
• Osteophytes, acetabular cysts, and extensive chondrolabral damage are risk factors for failure of FAI surgery.
• Extensive acetabular cartilage damage, central femoral osteophytes, and combined femoral cartilage and ligamentum teres damage represent independent negative predictors.
• Survival rates following hip arthroscopy progressively decrease with increasing prevalence of these three degenerative findings.

Graphical Abstract
Long-term cardiotoxicity in germ cell cancer survivors after platinum-based chemotherapy: cardiac MR shows impaired systolic function and tissue alterations
Authors: Beitzen-Heineke Antonia , Rolling Christina Charlotte , Seidel Christoph , Erley Jennifer , Molwitz Isabel , Muellerleile Kai , Saering Dennis , Senftinger Juliana , Börschel Niklas , Engel Nils Wolfgang , Bokemeyer Carsten , Adam Gerhard , Tahir Enver , Chen Hang 
Published: November 2023

Abstract
Objectives
Long-term toxicities of germ cell cancer (GCC) treatment are of particular importance in young men with a life expectancy of several decades after curative treatment. This study aimed to investigate the long-term effects of platinum-based chemotherapy on cardiac function and myocardial tissue in GCC survivors by cardiac magnetic resonance (CMR) imaging.

Methods
Asymptomatic GCC survivors ≥ 3 years after platinum-based chemotherapy and age-matched healthy controls underwent CMR assessment, including left ventricular (LV) and right ventricular (RV) ejection fraction (EF), strain analysis, late gadolinium enhancement (LGE) imaging, and T1/T2 mapping.

Results
Forty-four survivors (age 44 [interquartile range, IQR 37–52] years; follow-up time 10 [IQR 5–15] years after chemotherapy) and 21 controls were evaluated. LV- and RVEF were lower in GCC survivors compared to controls (LVEF 56 ± 5% vs. 59 ± 5%, p = 0.017; RVEF 50 ± 7% vs. 55 ± 7%, p = 0.008). Seven percent (3/44) of survivors showed reduced LVEF (< 50%), and 41% (18/44) showed borderline LVEF (50–54%). The strain analysis revealed significantly reduced deformation compared to controls (LV global longitudinal strain [GLS] -13 ± 2% vs. -15 ± 1%, p < 0.001; RV GLS -15 ± 4% vs. -19 ± 4%, p = 0.005). Tissue characterization revealed focal myocardial fibrosis in 9 survivors (20%) and lower myocardial native T1 times in survivors compared to controls (1202 ± 25 ms vs. 1226 ± 37 ms, p = 0.016). Attenuated LVEF was observed after two cycles of platinum-based chemotherapy (54 ± 5% vs. 62 ± 5%, p < 0.001).

Conclusion
Based on CMR evaluation, combination chemotherapy with cumulative cisplatin ≥ 200 mg/m2 is associated with attenuated biventricular systolic function and myocardial tissue alterations in asymptomatic long-term GCC survivors.

Clinical relevance statement
Platinum-based chemotherapy is associated with decreased systolic function, non-ischemic focal myocardial scar, and decreased T1 times in asymptomatic long-term germ cell cancer survivors. Clinicians should be particularly aware of the risk of cardiac toxicity after platinum-based chemotherapy.

Key Points
• Platinum-based chemotherapy is associated with attenuation of biventricular systolic function, lower myocardial T1 relaxation times, and non-ischemic late gadolinium enhancement.
• Decreased systolic function and non-ischemic late gadolinium enhancement are associated with a cumulative cisplatin dose of  ≥ 200 mg/m2.
• Cardiac MRI can help to identify chemotherapy-associated changes in cardiac function and tissue in asymptomatic long-term germ cell cancer survivors.

Graphical Abstract
End-to-end learning for joint depth and image reconstruction from diffracted rotation
Authors: Mel Mazen , Siddiqui Muhammad , Zanuttigh Pietro 
Published: November 2023

AbstractMonocular depth estimation is an open challenge due to the ill-posed nature of the problem at hand. Deep learning techniques proved capable of producing acceptable depth estimation accuracy but the lack of robust depth cues within RGB images severally limits their performance. Coded aperture-based methods using phase and amplitude masks encode strong depth cues within 2D images by means of depth-dependent Point Spread Functions (PSFs) at the price of a reduced image quality. In this paper, we propose a novel end-to-end learning approach for depth from diffracted rotation. A phase mask that produces a Rotating Point Spread Function (RPSF) as a function of defocus is jointly optimized with the weights of a depth estimation neural network. To this aim, we introduce a differentiable physical model of the aperture mask and exploit an accurate simulation of the camera imaging pipeline. Our approach requires a significantly less complex model and less training data, yet it outperforms existing methods for monocular depth estimation on indoor benchmarks. In addition, we address the image degradation problem by incorporating a non-blind and nonuniform image deblurring module to recover the sharp all-in-focus image from its blurred counterpart.
The influence of epidural anesthesia in pregnancies with scheduled vaginal breech delivery at term: a hospital-based retrospective analysis
Authors: Allert Roman , Brüggmann Dörthe , Raimann Florian J. , Zander Nadja , Louwen Frank , Jennewein Lukas 
Published: November 2023

Abstract
Introduction
Epidural anesthesia is a well-established procedure in obstetrics for pain relief in labor and has been well researched as it comes to cephalic presentation. However, in vaginal intended breech delivery less research has addressed the influence of epidural anesthesia. The Greentop guideline on breech delivery states that there’s little evidence and recommends further evaluation.

Objective
The aim of this study was to compare maternal and neonatal outcomes in vaginally intended breech deliveries at term with and without an epidural anesthesia.

Design
This study was a retrospective cohort study.

Sample
This study included 2122 women at term with a singleton breech pregnancy from 37 + 0 weeks of pregnancy on and a birth weight of at least 2500 g at the obstetric department of University hospital Frankfurt from January 2007 to December 2018.

Methods
Neonatal and maternal outcome was analyzed and compared between women receiving “walking” epidural anesthesia and women without an epidural anesthesia.

Results
Fetal morbidity, measured with a modified PREMODA score, showed no significant difference between deliveries with (2.96%) or without (1.79%; p = 0.168) an epidural anesthesia. Cesarean delivery rates were significantly higher in deliveries with an epidural (35 vs. 26.2%, p = 0.0003), but after exclusion of multiparous women, cesarean delivery rates were not significantly different (40.2% cesarean deliveries with an epidural vs. 41.5%, p = 0.717). As compared to no epidurals, epidural anesthesia in vaginal delivery was associated with a significantly higher rate of manual assistance (33.8 versus 52.1%) and a longer duration of birth (223.7 ± 194 versus 516.2 ± 310 min) (both p < 0.0001)".

Conclusion
Epidural anesthesia can be offered as a safe option for pain relief without increasing neonatal or maternal morbidity and mortality. Nevertheless, it is associated with a longer birth duration and manually assisted delivery.
One-stage combined ENT and dental surgical treatment of odontogenic sinusitis: a prospective study
Authors: Kocum Petr , Šedý Jiří , Traboulsi Joseph , Jirák Petr 
Published: November 2023

Abstract
Purpose
The study analyses outcomes of the surgical treatment of odontogenic sinusitis that concurrently address sinusitis and its dental source.

Methods
A total of 364 adult patients were included, representing 13% of all patients we have operated on for any rhinosinusitis over the past 18 years. The diagnosis was based on both ENT and dental examinations including CT imaging. Patients were divided into three groups: (1) FESS with dental surgery without antrotomy, (2) FESS with intraoral antrotomy, and (3) intraoral surgery without FESS. The mean postoperative follow-up was 15 months.

Results
First group involved 64%, second group 31%, and third group 6% of the cases. The one-stage combined ENT and dental approach was used in 94% of cases (group 1 and 2) with a success rate of 97%. Concerning FESS, maxillary sinus surgery with middle meatal antrostomy only was performed in 54% of patients. Oroantral communication flap closure was performed in 56% of patients (success rate 98%). Healing was achieved within 3 months. The majority (87%) of patients were operated on unilaterally for unilateral findings. Over the past 18 years, a 6% increase of implant-related odontogenic sinusitis was observed.

Conclusion
Odontogenic sinusitis is common, tending to be unilateral and chronic. Its dental source needs to be uncovered and treated and should not be underestimated. Close cooperation between ENT and dental specialists has a crucial role in achieving optimal outcomes. The one-stage combined surgical approach proves to be a reliable, safe, fast and effective treatment.
Philemon and Baucis death: a literature review
Authors: Sottmann Lukas , Schmeling Andreas 
Published: November 2023

Abstract Double death, i.e., two bodies at a scene, is relatively rare. The double death from natural causes of two close persons is called Philemon and Baucis death in the medicolegal literature. Despite being mentioned for the first time more than 50 years ago, all detailed case reports on this case constellation are from the last 15 years. A comprehensive review of the literature on this phenomenon has not yet been published. In this article, we review the available literature on Philemon and Baucis death. Pathophysiologically, it can be assumed that this phenomenon is a sub-form of so-called psychogenic death. Therefore, we equally review the literature on sudden cardiac death due to acute psychological stress.
Opportunities and challenges in combining immunotherapy and radiotherapy in esophageal cancer
Authors: Zhang Xinyu , Cai Xinsheng , Yan Chaoguang 
Published: November 2023

Abstract
Background
Immunotherapy has shown promise in the treatment of esophageal cancer, but using it alone only benefits a small number of patients. Most patients either do not have a significant response or develop secondary drug resistance. The combination of radiotherapy and immunotherapy appears to be a promising approach to treating esophageal cancer.

Purpose
We reviewed milestone clinical trials of radiotherapy combined with immunotherapy for esophageal cancer. We then discussed potential biomarkers for radiotherapy combined with immunotherapy, including programmed cell death-ligand 1 (PD-L1) status, tumor mutation burden (TMB), tumor-infiltrating lymphocytes, ct-DNA, imaging biomarkers, and clinical factors. Furthermore, we emphasize the key mechanisms of radiation therapy-induced immune stimulation and immune suppression in order to propose strategies for overcoming immune resistance in radiation therapy (RT). Lastly, we discussed the emerging role of low-dose radiotherapy (LDRT) , which has become a promising approach to overcome the limitations of high-dose radiotherapy.

Conclusion
Radiotherapy can be considered a triggering factor for systemic anti-tumor immune response and, with the assistance of immunotherapy, can serve as a systemic treatment option and potentially become the standard treatment for cancer patients.
A hospital-based therapeutic food pantry study for people living with cancer in New Orleans
Authors: Luo Ting , Elewonibi Bilikisu , Williams Donna 
Published: November 2023

Abstract
Introduction
Food pantries have the potential to improve health outcomes and quality of life for individuals living with cancer. Gender has been linked to certain cancer symptoms and dietary patterns. Nevertheless, the extent of research on the utilization of food pantries among this population, particularly with regard to gender differences, remains limited. The objective of this study is to explore the demographic characteristics and gender differences in quality of life, as well as the impact of cancer on the lives of individuals who utilize food pantry services.

Methods
Between February 26, 2019 and July 24, 2022, 400 people living with cancer were eligible to participate the University Medical Center New Orleans (UMC) food pantry. Participants were asked to provide demographic information and completed two health assessments related to the challenges in daily activities, nutrition, and mental health.

Results
The study participants had a mean age of 54.1, and the majority of the participants were female. More than half of the participants did not have access to a vehicle or use public transportation to access grocery stores. People living with cancer reported several quality of life issues, with the most prevalent challenges being interference of cancer with work, lack of energy, difficulty affording food, pain, and sleep problems. Additionally, less than half of the patients reported consuming fruits and vegetables on a daily basis, and males were found to be less likely to consume them compared to females.

Discussion
The current study sheds light on the characteristics and quality of life of individuals who utilize UMC food pantry services, as well as the impact of cancer on their lives. The findings reveal a gender disparity in fruit and vegetable consumption, with male individuals living with cancer reporting lower levels of consumption.

Implications for research and practice
Identifying and addressing food insecurity among people living with cancer are necessary. Meanwhile, partnerships with community organizations may be valuable in finding ways to assist cancer survivors in returning to work. Future studies could also focus on encouraging fruit and vegetable consumption, particularly among male individuals living with cancer.
Intraoral medical devices for sustained drug delivery
Authors: Alghanem Suhail , Dziurkowska Ewelina , Ordyniec-Kwaśnica Iwona , Sznitowska Małgorzata 
Published: November 2023

Abstract
Objectives
The oral cavity constitutes an attractive organ for the local and systemic application of drug substances. Oromucosal tablets, gels, or sprays are examples of the formulations applied. Due to the elution through the saliva, the residence time of the formulation at the application site is relatively short. Medical devices placed in the oral cavity, with a reservoir for an active substance, play an important role in solving this problem.

Materials and methods
In this review, we discuss the devices described in the literature that are designed to be used in the oral cavity, highlighting the advantages, disadvantages, and clinical applications of each of them.

Results
Among the intraoral medical devices, special types are personalized 3D-printed devices, iontophoretic devices, and microneedle patches.

Conclusion
We anticipate that with the development of 3D printing and new polymers, the technology of flexible and comfortable devices for prolonged drug delivery in the oral cavity will develop intensively.

Clinical relevance
The presented review is therefore a useful summary of the current technological state, when in fact none of the existing devices has been widely accepted clinically.
A full privacy-preserving distributed batch-based certificate-less aggregate signature authentication scheme for healthcare wearable wireless medical sensor networks (HWMSNs)
Authors: Rabie Osama Bassam J. , Selvarajan Shitharth , Hasanin Tawfiq , Mohammed Gouse Baig , Alshareef Abddulrhman M. , Uddin Mueen 
Published: November 2023

AbstractThe dynamic connectivity and functionality of sensors has revolutionized remote monitoring applications thanks to the combination of IoT and wireless sensor networks (WSNs). Wearable wireless medical sensor nodes allow continuous monitoring by amassing physiological data, which is very useful in healthcare applications. These text data are then sent to doctors via IoT devices so they can make an accurate diagnosis as soon as possible. However, the transmission of medical text data is extremely vulnerable to security and privacy assaults due to the open nature of the underlying communication medium. Therefore, a certificate-less aggregation-based signature system has been proposed as a solution to the issue by using elliptic curve public key cryptography (ECC) which allows for a highly effective technique. The cost of computing has been reduced by 93% due to the incorporation of aggregation technology. The communication cost is 400 bits which is a significant reduction when compared with its counterparts. The results of the security analysis show that the scheme is robust against forging, tampering, and man-in-the-middle attacks. The primary innovation is that the time required for signature verification can be reduced by using point addition and aggregation. In addition, it does away with the reliance on a centralized medical server in order to do verification. By taking a distributed approach, it is able to fully preserve user privacy, proving its superiority.
Female melon fruit flies, Zeugodacus cucurbitae, are attracted to a synthetic chemical blend based on male epicuticular components
Authors: Jacob Vincent , Ramiaranjatovo Gaëlle , Persyn Emma , Machara Aleš , Kyjaková Pavlína , Atiama-Nurbel Toulassi , Pompeiano Antonio , Benelli Giovanni , De Meyer Marc , Vaníčková Lucie 
Published: November 2023

AbstractThe melon fly, Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae), is considered to be the most destructive pest of melons and other related cucurbit crops worldwide. Despite the potential of behaviour-based control strategies, little is known about the mechanisms involved in female mate choice. Herein, we investigated the production and chemoreception of cuticular hydrocarbons in both sexes of Z. cucurbitae, and the behavioural responses they induce. We studied the epicuticular composition of virgin males and females, using two-dimensional gas chromatography coupled with mass spectrometric detection. Data were interpreted using multivariate factorial analysis. The differentiation of chemical profiles was consistently observed over time. In young individuals, the chemical profiles did not differ between sexes, while sex-specific differences were noted in mature flies. The fly olfactory sensitivity to these compounds was explored using gas chromatography combined with chopped triple electroantennography and electropalpography detectors. This extensive exploration of the pest olfactory sensitivity highlighted three compounds produced by the male. When blended, they induced a robust positive response in unmated naive females in a six-choice olfactometer. The responsiveness of other Tephritidae species (a polyphagous species Bactrocera dorsalis (Hendel) and the cucurbit specialist Dacus demmerezi (Bezzi)) to whole body extracts of Z. cucurbitae was also investigated. Our findings showed that Z. cucurbitae uses species-specific olfactory receptors to detect male produced compounds. In addition, the palps were sensitive to a female-specific component, 1,7-dioxaspiro[5.5]undecane, which the males produce in minute quantities. Overall, this study provides a starting point for a pheromone-based tephritid lure that targets unmated females. The potential implications for pest management are discussed.
Warming, not acidification, favours survival of non-indigenous over native gammarid species
Authors: Martinez Reyes Cindy , Cuthbert Ross N. , Langrehr Louisa , Briski Elizabeta 
Published: November 2023

AbstractAnthropogenic disturbances, including non-indigenous species (NIS) and climate change, have considerably affected ecosystems and socio-economies globally. Despite the widely acknowledged individual roles of NIS and global warming in biodiversity change, predicting the connection between the two still remains a fundamental challenge and requires urgent attention due to a timely importance for proper conservation management. To improve our understanding of the interaction between climate change and NIS on biological communities, we conducted laboratory experiments to test the temperature and pCO2 tolerance of four gammarid species: two native Baltic Sea species (Gammarus locusta and G. salinus), one Ponto‐Caspian NIS (Pontogammarus maeoticus) and one North American NIS (Gammarus tigrinus). Our results demonstrated that an increase in pCO2 level was not a significant driver of mortality, neither by itself nor in combination with increased temperature, for any of the tested species. However, temperature was significant, and differentially affected the tested species. The most sensitive was the native G. locusta which experienced 100% mortality at 24 °C. The second native species, G. salinus, performed better than G. locusta, but was still significantly more sensitive to temperature increase than either of the NIS. In contrast, NIS performed better than native species with warming, whereby particularly the Ponto-Caspian P. maeoticus did not demonstrate any difference in its performance between the temperature treatments. With the predicted environmental changes in the Baltic Sea, we may expect shifts in distributions of native taxa towards colder areas, while their niches might be filled by NIS, particularly those from the Ponto-Caspian region. Although, northern colder areas may be constrained by lower salinity. Additional studies are needed to confirm our findings across other NIS, habitats and regions to make more general inferences.