bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative E-cadherin and syndecan-1 protein expression in human and canine oral squamous cell carcinoma
Authors: Tabtieang Sirinun P. , Paphussaro Weejarin , Rungsipipat Anudep , Kunnasut Nanthida , Ploypetch Sekkarin , Phattarataratip Ekarat , Suriyaphol Gunnaporn 
Published: January 2024

AbstractOral squamous cell carcinoma (OSCC) is a prevalent form of oral cancer in humans and dogs. The altered expression of cell adhesion molecules, including E-cadherin (CDH1) and syndecan-1 (SDC1), is involved in cancer progression. This study aimed to investigate the protein expression of CDH1 and SDC1 in early and late clinical stages of human and canine OSCC (hOSCC and cOSCC, respectively), using immunohistochemistry. Formalin-fixed and paraffin embedded tissue blocks were obtained from 21 hOSCC, 8 human normal gingiva, 26 cOSCC, and 13 canine normal gingiva. Clinical stages and histological subtypes of samples were evaluated. The results indicated that both human and canine OSCC exhibited reduced levels of CDH1 and SDC1 expression at the cell membrane regardless of clinical stage or histological subtype. Additionally, decreased levels of total SDC1 expression were observed in hOSCC compared with normal controls. In conclusion, this study demonstrates a similarity in the immunohistochemical expression of CDH1 and SDC1 between humans and dogs with OSCC, lending support to the potential use of dogs as a model for studying human head and neck squamous cell carcinoma.
The Robbery of Financial Institutions in Witbank Policing Area, South Africa
Authors: Nkosi Samuel Khehla , Mofokeng Jacob Tseko 
Published: January 2024

The motives for violent crime are wide ranging. Results show that violence in commercial robbery was often used to achieve the material goals of the offense (to steal money or goods) by ensuring compliance and by overcoming resistance. Also found was that violence in assault was used purposively to achieve the immediate goal of harming the victim. In both cases, violence was used in ways that could be directly attributed to the successful commission of the offense. In other cases, violence performed additional functions, such as enhancing the status of the offender, generating a reputation for toughness on the street, providing a response to challenges to masculinity, giving an outlet for aggression and the desire to fight, and as a means of administering retaliation and revenge through informal justice; violence of this kind is used as an expression of a value system that condones violent behavior. Methodologically, the research is qualitative, involving semi-structured face-to-face oral interviews (open-ended) with 30 armed robbers in prison custody in Witbank, South Africa. Armed robbery is a type of robbery aided by weapon(s) to threaten, force and deprive a person or persons of the right to private, public or corporate belongings. The analytical framework employed is interpretive phenomenology, to capture the holistic worldview of the offender sample. Secondary data comes from both the eletronic media. Findings are presented under four systematic themes: “challenges of policing bank robberies and the extent of the harm, speculative motives, planning and duration of planning process, and tools of trade”. In the following, these themes are explained making use of participants’ statements.
Role of military cooperation in Vietnam-Russia relations
Authors: Zaręba Michał 
Published: January 2024

The primary purpose of this article is the analysis of the evolution of bilateral relations between the Socialist Republic of Vietnam (SRV) and the Russian Federation in the field of military cooperation. It gives answers to following research questions: 1) what is the role of defence collaboration in bilateral ties, 2) what are the most essential elements of Russia-Vietnam military relations, 3) what are the common reasons/ incentives for developing links regarding arms trade, 4) do the Russian annexation of Crimea in 2014 and invasion of Ukraine in 2022 change goals of Vietnamese politics towards Moscow, 5) How do Chinese and US factor affect military cooperation between Russia and Vietnam? The theses of this paper assume that: 1) the government in Hanoi maintains friendly relations with Moscow on the political level in the face of the conflict in Ukraine and continues military cooperation, however Russian arms exports to Vietnam has declined, 2) Vietnam diversifies weapon trade partners expanding cooperation with Israel, Belarus, US and South Korea, but Russia still remains crucial arms importer for Hanoi.
The analysis is focused mainly on the situation from 2002 to the present, and intends to examine the evolution of military cooperation between Hanoi and Moscow after the signing of the Declaration on Strategic Partnership. The article includes a short overview of Russia-Vietnam relations emphasizing its strong historical background. Paper is also focused on important arms trade contracts, agreements on military cooperation, includes statistics published by Stockholm International Peace Research Institute (SIPRI) to show the scale of collaboration, and points out major challenges for future cooperation.
Consolidación de un modelo palaciego basado en la domus vitruviana: del Palazzo dei Tribunali de Roma al Palazzo Te de Mantua = The consolidation of a palatial model based on the Vitruvian domus: From the Palazzo dei Tribunali in Rome to the Palazzo Te in Mantua
Authors: Gómez Gil Antonio Miguel , Mestre Martí María 
Published: January 2024

AbstractThe article highlights that the free-standing palaces of the late Italian Renaissance, built by archi­tects of Bramante’s circle, share the same compositional scheme in plan, based on the study of the Vitruvian domus. Starting with the Palace of the Chancellery in Rome, the private palaces’ typology was consolidated during the 16th century. It consists of the articulation of the floor plan throughout two orthogonal axes: a main one clearly inspired by the longitudinal axis of the classical domus and an added second transverse axis, which joins two new and secondary accesses. This spatial organization generates a building divided into four almost autonomous parts, endowed with their own communication elements. Although articulated by a central cortile, it allows independent func­tioning. This typological model should be considered as one of the taxonomies that have so far not been highlighted in the Italian Mannerist architecture of Bramante’s circle. ResumenEl artículo demuestra que los palacios exentos, del Bajo Renacimiento italiano, ejecutados por ar­quitectos del círculo de Bramante, comparten un mismo esquema compositivo en planta, basado en el estudio de la domus vitruviana. A partir del Palazzo della Cancelleria en Roma, la tipología del palacio privado se va consolidando durante el siglo XVI. Esta consiste en la articulación de la planta mediante dos ejes ortogonales: uno principal, claramente inspirado en el eje longitudinal de la domus clásica y un añadido segundo eje transversal, que une dos accesos nuevos y secun­darios. Dicha organización espacial genera un edificio dividido en cuatro partes casi autónomas, dotadas de elementos de comunicación propios, que, aunque articuladas por un cortile central, posibilitarían un funcionamiento independiente. Este modelo tipológico debe considerarse como una de las taxonomías no puestas en valor hasta ahora en la arquitectura manierista italiana del círculo de Bramante.
Sobre viajes y componentes: incursiones de Osamu Ishiyama en el ensamblaje de la vivienda = On Trips and Components: Osamu Ishiyama’s Forays into House Assembly
Authors: Prieto Castro Salvador 
Published: January 2024

AbstractIn 1986, the Japanese architect Osamu Ishiyama published the book Warau Jūtaku (Laughing House), where he humorously aimed to demonstrate that the houses he designed could be built for less than the average price of a typical house at that time. A decade prior, following the advice of his teacher Kenji Kawai, he embarked on a series of trips to the United States, which eventually led to the production of a series of houses through his company Dam Dan. Ishiyama capitalized on the price difference in building materials by industrializing an assembly process through the importation of containers from North America. These experiences in the realm of assembly laid the foundation for what Ishiyama called Akihabara kankaku (Akihabara Sensibility). Inspired by the Akihabara market, the architect envisioned the home as a self-constructed artifact made from readily available components. ResumenEn 1986 el arquitecto japonés Osamu Ishiyama publicó el libro Warau Jūtaku (Casa de la risa), en el que de una forma jocosa pretendía demostrar que las viviendas que diseñaba podían construirse por debajo del precio medio de una casa típica de la época. Una década antes, aconsejado por su maestro Kenji Kawai, comenzaba un ciclo de viajes a Estados Unidos que desembocarían en la producción de una serie de viviendas con su compañía Dam Dan. Ishiyama aprovechó la diferencia de precio de los materiales de construcción para industrializar un proceso de ensamblaje a través de la importación de contenedores desde Norte América. Estas incursiones en el mundo del ensamblaje cimentaron la idea de Ishiyama en torno a lo que llamó Akihabara kankaku (Sensibilidad Akihabara). El mercado de Akihabara inspiró la idea del arquitecto, de que la vivienda debía ser un artefacto autoconstruido a partir de componentes de fácil adquisición.
The Impact of Divorce on The Social Development of Children 5-6 Years Old: Peter L. Berger's Social Construction Perspective
Authors: Karomah Rosi Tunas , Prasetyo Andri , Juleha Siti 
Published: January 2024

<em>Social emotional development of children needs to be given strong support from the family. The condition of an incomplete family will cause differences in </em>aspects<em> of development, one of which is social-emotional in children. The purpose of this paper is to ascertain how children's social development is affected by single parents.The purpose of this paper is to ascertain how children's social development is affected by single parents. Descriptive qualitative method was used. Single parents whose children attend Kindergarten Mentari Ambarawain become research participants. Data collection techniques include interviews, observation, and documentation. The findings of this study have a number of implications for early childhood social and emotional development. Children suffer from low self-esteem, uncontrolled emotions, inability to obey rules, bad behavior, and difficulty adjusting to their environment as a result. The relationship between a single parent and a child will greatly influence the social emotional attitude of the child.</em>
Reflective Boundary Conditions Coupled With the SPH Method for the Three-Dimensional Simulation of Fluid-Structure Interaction With Solid Boundaries
Authors: Filho Carlos Alberto Dutra Fraga 
Published: January 2024

Abstract
Fluid-structure interaction occurs, for example, in wave impacts against reservoir walls, coastal structures offshore platforms in the ocean, bridge piers, breakwaters), coastal flooding, sloshing phenomenon, tsunamis, and biomedical applications. In the threedimensional fluid-structure interaction simulation performed by the Lagrangian (meshfree) particle methods, the fluid particles' collisions treatment against solid boundaries using a
realistic reflective physical approach, replacing artificial computational techniques (which use fictitious particles and unnatural repulsive forces) is an advance in the treatment of the contours, in the continuum domain. The benchmark study of a three-dimensional dam-breaking flow over a dry bed generating a wave that impacts a tall structure–a rigid obstacle fixed inside the reservoir–using the Smoothed Particle Hydrodynamics Method coupled with the reflective boundary conditions is presented in this paper. The findings showed good agreement with the previous literature data, proving the applicability of the reflective technique in the simulation of fluid-structure interaction problems in three-dimensional domains.
Cytoplasmic accumulation and plasma membrane association of anillin and Ect2 promote confined migration and invasion
Authors: Konstantopoulos Konstantinos , Tran Avery , Wisniewski Emily , Mistriotis Panagiotis , Stoletov Konstantin , Parlani Maria , Amitrano Alice , Ifemembi Brent , Lee Se Jong , Bera Kaustav , Zhang Yuqi , Tuntithavornwat Soontorn , Afthinos Alexandros , Kiepas Alexander , Jamieson John , Zuo Yi , Habib Daniel , Wu Pei Hsun , Martin Stuart , Gerecht Sharon , Gu Luo , Lewis John , Kalab Petr , Friedl Peter 
Published: January 2024

Abstract
Cells migrating in confinement experience mechanical challenges whose consequences on cell migration machinery remain only partially understood. Here, we demonstrate that a pool of the cytokinesis regulatory protein anillin is retained during interphase in the cytoplasm of different cell types. Confinement induces recruitment of cytoplasmic anillin to plasma membrane at the poles of migrating cells, which is further enhanced upon nuclear envelope (NE) rupture(s). Rupture events also enable the cytoplasmic egress of predominantly nuclear RhoGEF Ect2. Anillin and Ect2 redistributions scale with microenvironmental stiffness and confinement, and are observed in confined cells in vitro and in invading tumor cells in vivo. Anillin, which binds actomyosin at the cell poles, and Ect2, which activates RhoA, cooperate additively to promote myosin II contractility, and promote efficient invasion and extravasation. Overall, our work provides a mechanistic understanding of how cytokinesis regulators mediate RhoA/ROCK/myosin II-dependent mechanoadaptation during confined migration and invasive cancer progression.
Catalytic Single-particle Plasmonic Nanogap Reactors with Precisely-aligned Molecular Monolayers
Authors: Baumberg Jeremy , Kang Gyeongwon , Hu Shu 
Published: January 2024

Abstract

Plasmonic nanostructures can both drive and interrogate light-driven catalytic reactions. Sensitive detection of reaction pathways is achieved by confining optical fields near the active surface. However, effective control of the reaction kinetics remains a challenge in order to utilize nanostructure constructs as efficient chemical reactors. Here we present a nanoreactor construct exhibiting high catalytic and optical efficiencies, based on a nanoparticle-on-mirror (NPoM) platform. We observe and track pathways of the Pd-catalysed C-C coupling reaction of molecules within a set of nanogaps presenting different chemical surfaces. Atomic monolayer coatings of Pd on the different Au facets enable tuning of the reaction kinetics. Systematic analysis shows the catalytic efficiency of NPoM-based nanoreactors greatly improves on platforms based on aggregated nanoparticles. More importantly, we show Pd monolayers on the nanoparticle or on the mirror play significantly different roles in the reaction kinetics. Such nanoreactor constructs therefore yield clearer design rules for plasmonic catalysis.
Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autism
Authors: Krueger Bruce , Dorsey Susan , Mocci Evelina , Lane Malcolm 
Published: January 2024

Abstract

There is an increased incidence of autism among the children of women who take the anti-epileptic, mood-stabilizing drug, valproic acid (VPA) during pregnancy; moreover, exposure to VPA in utero causes autistic-like symptoms in rodents and non-human primates. Analysis of RNA-seq data obtained from E12.5 fetal mouse brains 3 hours after VPA administration to the pregnant dam revealed that VPA rapidly and significantly increased or decreased the expression of approximately 7,300 genes. No significant sex differences in VPA-induced gene expression were observed. Expression of 399 autism risk genes was significantly altered by VPA as was expression of 255 genes that have been reported to play fundamental roles in fetal brain development but are not otherwise linked to autism. Expression of genes associated with intracellular signaling pathways, neurogenesis, and excitation-inhibition balance as well as synaptogenesis, neuronal fate determination, axon and dendritic development, neuroinflammation, circadian rhythms, and epigenetic modulation of gene expression was dysregulated by VPA. The goal of this study was to identify mouse genes that are: (a) significantly up- or down-regulated by VPA in the fetal brain and (b) known to be associated with autism and/or to play a role in embryonic neurodevelopmental processes, perturbation of which has the potential to alter brain connectivity and, consequently behavior, in the adult. The set of genes meeting these criteria provides potential targets for future hypothesis-driven studies to elucidate the proximal causes of errors in brain connectivity underlying neurodevelopmental disorders such as autism.
RETRACTED: A novel mechanism of a protease inhibitor protein, Xbpi-1, against Acyrthosiphon pisum
Authors: Zhang Tingting , Li Qiannan , Li Xiaokang , Bu Fukang , Yu Yinchen , Liu Meng , Li Tonghao , Zheng Li , Mao Jianjun , Zeng Fanrong 
Published: January 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Association between inter-limb asymmetry and endurance running performance in healthy populations: A systematic review
Authors: D'Hondt Joachim , Chapelle Laurent , Bishop Chris , Aerenhouts Dirk , De Pauw Kevin , Clarys Peter , D'Hondt Eva 
Published: January 2024

Abstract

Backgroundː The presence of inter-limb asymmetry in the human body has traditionally been perceived to be detrimental for athletic performance. However, a systematic review addressing and comprehensively assessing the association of asymmetry between the lower limbs and endurance running performance is currently lacking.
Objective: The main purpose of this systematic review was to examine the relationship between lower inter-limb asymmetry and running performance in healthy endurance runners. The secondary objective was to identify possible avenues for further research in this area.
Methodsː Pubmed, Web of Science and SPORTDiscus were systematically searched for studies investigating the relationship between lower inter-limb asymmetry and (determinants of) running performance in healthy and injury-free endurance runners. The quality of studies eligible for inclusion was assessed using the Downs and Black Quality Index Tool.
Resultsː Out of 4817 articles screened, 8 studies were included in this review. The quality score of the included research varied between 5/10 and 9/10. Except from one finding demonstrating a positive association between peak ankle dorsiflexion asymmetry and running performance, all other lower inter-limb asymmetry outcome measures were either negatively (N = 16) or not significantly (N = 30) associated with running performance.
Conclusionsː A high heterogeneity across study methods and outcomes was apparent, making it difficult to draw a straightforward conclusion. Despite one study showing a positive relationship, the results demonstrate that some, but not all, metrics of functional, morphological, kinematic and kinetic inter-limb asymmetry are negatively or not associated with running performance. Thus, a more extensive high-quality body of research is essential to determine whether and to what extent asymmetry between the lower limbs could affect endurance running performance as well as to establish potential trade-off values for practitioners in developing training programs.
Full-color and time-valve controllable long-persistent luminescence from all-inorganic halide perovskites
Authors: Yan Dongpeng , Chen Tianhong 
Published: January 2024

Abstract

Long persistent luminescence (LPL) has gained considerable attention for the applications in decoration, emergency signage, information encryption and biomedicine. However, recently developed LPL materials – encompassing inorganics, organics and inorganic-organic hybrids – often display monochromatic afterglow with limited functionality. Furthermore, triplet exciton-based phosphors are prone to thermal quenching, significantly restricting their high emission efficiency. Here, we present a straightforward wet-chemistry approach for fabricating multimode LPL materials by introducing both anion (Br−) and cation (Sn2+) doping into hexagonal CsCdCl3 all-inorganic perovskites. This process involves establishing new trapping centers from [CdCl6 − nBrn]4− and/or [Sn2 − nCdnCl9]5− linker units, disrupting the local symmetry in the host framework. These halide perovskites demonstrate obviously extended afterglow duration time (> 2,000 s), nearly full-color coverage, and high photoluminescence quantum yield (~ 84.47%). Moreover, they exhibit remarkable anti-thermal quenching properties within the temperature range of 297 to 377 K. Notably, the color-changed time valve of CsCdCl3:x%Br can be precisely controlled by manipulating the concentration of Br− ions, distinguishing them from conventional color-varying long-afterglow materials. Additionally, CsCdCl3:x%Br display time- and temperature-dependent luminescence, while CsCdCl3:x%Sn exhibit forward and reverse excitation-dependent Janus-type luminescence. These characteristics endow the LPL materials with dynamic tunability, offering new opportunities in high-security anti-counterfeiting and 5D information coding. Therefore, this work not only introduces a local-symmetry breaking strategy for simultaneously enhancing afterglow lifetime and efficiency, but also provides new insights into the multimode LPL materials for applications in luminescence, photonics, and information storage.
Toxicity of nanosized photocatalysts on brine shrimp (Artemia Salina) and Lactuca sativa: effects of particle size and the presence of zeolite Y
Authors: Scalco Adriano Vinicius , Figueiredo Elaine Basilio , Gimenes Marcelino Luiz , Ferrari Ana Maria da Cruz , Fernandes Nádia Regina Camargo 
Published: January 2024

Abstract
Heterogeneous photocatalysts are considered “green” and non-toxic materials for environmental remediation. Although nanosized photocatalysts can promote optimistic pollutant degradation rates, the assessment of their toxicity is highly recommended. In this work, NaY zeolite-supported Niobium oxides were synthesized by deposition, precipitation, and thermal hydration methods. Ecotoxicity tests with Artemia salina and phytotoxicity tests with Lactuca sativa were performed to evaluate the toxicity of the nanomaterials. Nb2O5 prepared by thermal hydration method was the lowest phytotoxic catalyst, but the most ecotoxic, with LC50 equal to 85 mg L-1. The presence of NaY reduced the toxicity of the oxides. The 10% Nb2O5/NaY material showed reduced toxicity and did not present an inhibition effect on the development of Lactuca sativa seeds. These findings suggest that the nanoparticles can have significant interaction with biological structures, emphasizing the importance of careful handling of this material, as it is not completely absent of toxicity.