bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cascaded sum frequency generation of ultraviolet laser radiation at 228  nm based on stimulated Raman adiabatic passage
Authors: Jin Yintong , Chen Zhen , Zhang Jialiang , Chen Changshui 
Published: November 2023

A cascaded sum frequency generation (SFG) conversion scheme based on the stimulated Raman adiabatic passage (STIRAP) technique is proposed for generating an ultraviolet laser radiation at 228 nm. The conversion involves two simultaneous SFG processes, in which the signal laser radiation is converted to ultraviolet laser radiation through a negligible intermediate laser radiation. Dark state expressions and adiabatic conditions are given. Numerical simulations demonstrate the efficient conversion processes in a nonlinear LaBGeO5 (LBGO) crystal, and the effects of the coupling modulation function, pump laser intensity, and temperature on the quantum conversion efficiency are investigated. Tunable output of ultraviolet laser radiation in the 210–250 nm range is achieved by varying the signal or pump laser radiation wavelength while maintaining other input parameters. The large amount of optical data obtained in this work will contribute to the generation of deep ultraviolet laser sources based on nonlinear cascaded frequency conversion.
Association between treatment outcome and age in tuberculosis and diabetes patients: a population analysis
Authors: Yeraliyeva L. T. , Issayeva A. M. 
Published: November 2023

Background. The undoubted importance of this work lies in the fact that for the first time in the Republic of Kazakhstan, an analysis is being made of the relationship between age and treatment outcome in patients with a comorbid diagnosis of tuberculosis and diabetes mellitus.Purpose of the study. Identification of the correlation between the age of patients with tuberculosis with diabetes mellitus and the outcome of treatment.Materials and methods. Cross-sectional retrospective study of 2,125 patients with TB and diabetes mellitus out of a total of 43,807 of all patients diagnosed with TB (2017-2019). The study analyzed the data of patients with comorbidity from all regions of Kazakhstan (data from 14 regions and 3 cities of republican significance) (2017-2019).Results. A high prevalence of tuberculosis morbidity with a concomitant diagnosis of diabetes mellitus in the age group from 45 to 64 years was revealed. This group consisted of 1193 patients out of 2115 (56.4% of the total number of patients with tuberculosis and diabetes mellitus). The average age of all studied patients with DM was 54.7±13.4 years. There is a positive correlation between age and treatment outcome in TB patients. Mortality was higher in the age group over 45 years old – OR95%CI = 0.213 [0.019–2.362], p – 0.0000015 (p < 0.05).
Modeling the renoprotective mechanisms of SGLT2 inhibition in hypertensive chronic kidney disease
Authors: Clemmer John S. , Yen Timothy E. , Obi Yoshitsugu 
Published: November 2023

AbstractSodium‐glucose cotransporter (SGLT)‐2 inhibitors have recently been approved for chronic kidney disease (CKD) based on their ability to lower proteinuria and slow CKD progression independent of diabetes status. In diabetic renal disease, modulation of tubuloglomerular feedback (TGF) leading to lower intraglomerular pressure has been postulated as one of the mechanisms of renal protection with SGLT2 inhibition; however, this mechanism has not been sufficiently explored in non‐diabetic CKD. We hypothesized that SGLT2 inhibition exerts renoprotection in CKD through increasing TGF despite normoglycemia. To test this hypothesis, we used an integrative mathematical model of human physiology, HumMod. Stage 3 CKD conditions were simulated by reducing nephron mass which was associated with hypertension, low glomerular filtration rate (GFR) (55 mL/min), hyperfiltration of remnant nephrons, elevated albuminuria (500 mg/day), and minimal levels of urinary glucose (0.02 mmol/L). SGLT2 inhibition was associated with acute reductions in GFR associated with afferent arteriolar vasoconstriction due to TGF. After 12 months, glomerular pressure, nephron damage, and chronic GFR decline were reduced with SGLT2 inhibition with additional SGLT1 inhibitory effects further enhancing these effects. This model supports the use of SGLT2 inhibitors to reduce hyperfiltration in CKD and mitigate renal disease progression, even in the absence of diabetes.
Bioinformatic analysis of smoothelin family members supports tissue‐specific functions of unique C‐terminal calponin homology domains
Authors: Garg Dhruv , Fisher Steven A. 
Published: November 2023

AbstractSmoothelins are cytoskeletal proteins with a single C‐terminal calponin homology domain type 2 (CHD2). Little is known about the significance of variation in SMTN CHD2 domains, addressed here through analysis of public databases. A conserved 152 nt penultimate constitutive exon present in all SMTNs encodes helices II‐IV of CHD2 with high identity (nt/aa 63/65%). Variable CHD2s of SMTN (helices IV‐VI) are generated by alternative splicing of 165 nt exon E20. E20 and the CHD2 it encodes have high homology with the terminal constitutive exon of SMTNL1 (E8; nt/aa 72/75% identity). Unique to these CHD2 variants are a conserved extended nine amino acid C‐terminal tail containing KTKK ubiquitination motifs. When E20 of SMTN is skipped (SMTN E20−), constitutive terminal E21 codes for helices IV‐VI of CHD2. SMTN E21 has high identity with the terminal exon of SMTNL2 (E8; nt/aa 75/81% identity of aligned sequences) except for coding for a unique extended C‐terminus (24 nt; 8aa) conserved only in mammals. SMTN isoform expression is tissue‐specific: SMTNE20− and SMTNE20+ are highly expressed in SMC and non‐muscle cells, respectively, while SMTNL1 + 2 are highly expressed in skeletal muscle cells. Tissue‐specific expression of SMTN CHD2s with unique helices IV‐VI suggest tissue‐specific functions that require further study.
Serum biomarkers for liver fibrosis assessment
Authors: Maroto-García Julia , Moreno Álvarez Ana , Sanz de Pedro María P. , Buño-Soto Antonio , González Álvaro 
Published: November 2023

Abstract
Liver fibrosis is the result of chronic liver injury of different etiologies produced by an imbalance between the synthesis and degeneration of the extracellular matrix and dysregulation of physiological mechanisms. Liver has a high regenerative capacity in the early stage of chronic diseases so a prompt liver fibrosis detection is important. Consequently, an easy and economic tool that could identify patients with liver fibrosis at the initial stages is needed. To achieve this, many non-invasive serum direct, such as hyaluronic acid or metalloproteases, and indirect biomarkers have been proposed to evaluate liver fibrosis. Also, there have been developed formulas that combine these biomarkers, some of them also introduce clinical and/or demographic parameters, like FIB-4, non-alcoholic fatty liver disease fibrosis score (NFS), enhance liver fibrosis (ELF) or Hepamet fibrosis score (HFS). In this manuscript we critically reviewed different serum biomarkers and formulas for their utility in the diagnosis and progression of liver fibrosis.
Evaluating hydraulic parameters in clays based on in situ tests
Authors: Lech Mariusz , Bajda Marek , Markowska-Lech Katarzyna , Rabarijoely Simon 
Published: November 2023

Abstract
The permeability of soil is an important factor controlling the flow of water through the subsoil. The article presents the results of studies of hydraulic parameters for overconsolidated clays using in situ tests. Using the excess pore pressure normalization technique, both in the case of monotonic and dilatory dissipation tests, and the time at which 50% dissipation of excess pore water pressure takes place, as well as taking into account the rigidity index of the analyzed soil, it was possible to estimate the permeability and consolidation coefficients for the analyzed clays. Based on these studies, simple relationships between the permeability coefficient and the soil behavior-type index are proposed. Proposed formulas may be applied for overconsolidated cohesive soils with soil behavior-type index values within the range of 2.05–3.30 and described in Robertson’s chart as overconsolidated silty clays, clays and heavily overconsolidated and cemented fine-grained soils. Although our proposal of determining flow parameters has been calibrated only for two analyzed cases, its utility for wider use in other overconsolidated fine-grained soils may also be taken into account.
The role of halal requirements, health-environmental factors, and domestic interest in food miles of apple fruit
Authors: Nazaruddin La Ode , Nugraha Widya Satya , Nurhasan Haris Munandar , Lencsés Enikő , Fekete-Farkas Mária , Gyenge Balázs 
Published: November 2023

Abstract
This study examines the indirect and direct factors affecting the preference for distant travel of apple fruit (food miles or FMs) in Indonesia, a Muslim-majority country. This research employs a quantitative consumer survey of 522 respondents in Indonesia from January to February 2023. Data were collected online (i.e. via social media), and the respondents were chosen randomly. Data were then analysed using a partial least square-structural equation model to prove the proposed hypotheses using Rstudio. This investigation has some principal findings. First, domestic interest and health-environment benefits directly affect the preference for short food miles (SFMs). Second, the halal requirements do not directly affect the choice of SFMs but indirectly affect the preference for SFMs through health-environmental benefits. In sum, the choice for SFMs is affected by domestic interest (direct), health-environmental benefits (direct), and halal requirements (indirect). This study finally has a theoretical contribution to the interplay among green supply chain, halal food supply chain, and food security.
Benevento and Salerno
Authors: Zornetta Giulia 
Published: November 2023

Abstract
After the Carolingian conquest of the Lombard Kingdom in 774, the Duchy of Benevento became an independent principality. Duke Arechis (758–787) proclaimed himself princeps gentis Langobardorum, thus opposing the political authority of the new King of the Lombards, Charlemagne. During the second half of the 8th century, Arechis refounded Salerno as the second capital city of Lombard Southern Italy by building a palace which stood as a marker of his political authority within the urban landscape. When the competition between two factions of the Beneventan aristocracy led to a civil war (839–849), Salerno became first a gathering place for members of the faction opposing Prince Radelchis and then the capital city of a new Lombard principality. By considering both written and archaeological sources, this paper focuses on the social and political aspects that led to the urban development of Salerno and challenged the role of Benevento during the 8th and 9th centuries. Some final considerations contextualise the rise of Capua as a third capital city in Lombard Southern Italy during the 9th and 10th centuries.
Il soggiorno di Caterina da Siena a Pisa nel 1375
Authors: Paganelli Jacopo 
Published: November 2023

Abstract
This essay aims to shed light on the period spent by Catherine of Siena in Pisa during the year 1375. Catherine was not only a woman of faith and devotion, but also a leading political player in late 14th-century Tuscany, in direct contact with the Apostolic See through the members of her clique. Why did the lord of Pisa, Pietro Gambacorta, summon her to his city? What networks of relations did Catherine’s arrival fit into? What were the tangible consequences of her stay in Pisa?
Francesco Barberini als Politiker
Authors: Becker Rotraud 
Published: November 2023

Abstract
Francesco Barberini, the cardinal nephew of Pope Urban VIII (1623–1644), is known to researchers primarily as a patron of the arts. However, he was a member of numerous dicasteries in the Roman Curia and held the office of head of the papal secretariat of state throughout the pontificate. In the early years he hardly appeared in this function. From 1631 onwards, testimonies of his involvement in the correspondence of the office become more frequent in the archives and provide information about his desire to play an active role in papal politics. Detailed autograph minutes to letters sent in cipher to the nuncios in Vienna deal with topics such as the mostly futile request of the imperials for subsidies, the rejection of criticism of the papal policy of neutrality and the improvement of relations between the Holy See and the imperial court. In addition, the attempt to influence the political convictions of members of religious orders working in Vienna and, in particular, the need to win the emperor’s approval for the precedence of the prefect of Rome before the imperial envoy play a noticeable role.
Existence results for some stochastic functional integrodifferential systems driven by Rosenblatt process
Authors: Diop Amadou , Diop Mamadou Abdoul , Ezzinbi Khalil , Kpizim Essozimna 
Published: November 2023

Abstract
This work investigates the existence and uniqueness of mild solutions to a class of stochastic integral differential equations with various time delay driven by the Rosenblatt process. We can obtain alternative conditions that guarantee mild solutions by using the resolvent operator in the Grimmer sense, stochastic analysis, fixed-point methods, and noncompact measures. We give an example to illustrate the theory.
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease
Authors: Hess Anja , Gentile Stefan D , Ben Saad Amel , Rahman Raza‐Ur , Habboub Tim , Pratt Daniel S , Mullen Alan C 
Published: November 2023

AbstractMetabolic dysfunction‐associated steatotic liver disease (MASLD) is a growing cause of morbidity with limited treatment options. Thus, accurate in vitro systems to test new therapies are indispensable. While recently, human liver organoid models have emerged to assess steatotic liver disease, a systematic evaluation of their translational potential is still missing. Here, we evaluated human liver organoid models of MASLD, comparatively testing disease induction in three conditions: oleic acid, palmitic acid, and TGF‐β1. Through single‐cell analyses, we find that all three models induce inflammatory signatures, but only TGF‐β1 promotes collagen production, fibrosis, and hepatic stellate cell expansion. In striking contrast, oleic acid ameliorates fibrotic signatures and reduces the hepatic stellate cell population. Linking data from each model to gene expression signatures associated with MASLD disease progression further demonstrates that palmitic acid and TGF‐β1 more robustly model inflammation and fibrosis. Our findings highlight the importance of stratifying MASLD organoid models by signatures of clinical disease progression, provide a single‐cell reference to benchmark future organoid injury models, and allow us to study evolving steatohepatitis, fibrosis, and HSC susceptibility to injury in a dynamic, multi‐lineage human in vitro system.
Sufism Literature: Divinity Philosophy in Taufiq al-Hakim’s Short Story Arinillah
Authors: Zulhelmi Zulhelmi , Nurchalish Nurchalish , Syarifuddin Syarifuddin , Walidin Muhammad , Muskar Rahlina 
Published: November 2023

PurposeThis article aimed to know how a Modern Egyptian writer, Taufiq al-Hakim, enlightened his readers to believe Allah's existence and could feel His presence more closely. MethodAs qualitative research, this article relied on verbal data in the form of sentences or paragraphs available in the short story. In collecting the data, the authors read carefully Arinillah, Taufiq al-Hakim’s short story; and made some notes on sentences or paragraphs considered to indicate ways of enlightening Allah’s existence. The data were analyzed qualitatively using Sufism literature theories to identify Taufiq al-Hakim’s ideas of Allah’s existences and his ways of educating the readers to believe in Allah. Results/FindingsTaufiq al-Hakim's ways of educating his readers to believe in Allah’s existence through the storyline beginning with curiosity and ending with regret. He did not curb the readers’ curiosity to know Allah's existence, but left them to play in the adventure of Sufistic spiritual imagination. At the end of the story, they regretted because they with their mind were not able to identify the existence of Allah, the greatest. ConclusionThe article concluded that Arinillah storyline was Taufiq al-Hakim’s way in interpreting hadith of the Prophet Muhammad SAW regarding prohibition to think Allah’s substance; and it was not true that he violated such a prohibition.
Diversity of early flowering plants of the Ulytau mountains (Central Kazakhstan)
Authors: Pozdnyakova Y. , Sailau A. , Solyanov D. , Aitisheva L. , Tatina Y. , Britko V. 
Published: November 2023

Early flowering plants (ephemers and ephemeroids) are an important component of the biosystem of steppes and deserts. These species form perennial pasture communities, for early grazing. The present work was conducted to evaluate the floristic checklist and ecological uniqueness of early flowering plants of Central Kazakhstan, in the forest-steppe regions of Em-Bulak region and Edige mountains, during 2021 and 2022. A total of 26 species of ephemers and ephemeroids were recorded, which belong to 16 families: Liliaceae – 3 species, Asteraceae – 3 species, Ranunculaceae – 3 species, Rosaceae – 3 species, Brassicaceae – 2 species, Boraginaceae – 2 species, the other families are represented by one species. According to ecomorphological characteristics: 8 species (31%) belong to the xerophyte group, 6 (23%) to the xeromesophyte group, 7 (27%) to the mesoxerophyte group and 5 (19%) to the mesophyte group. Also, as a result of our research we found two species of plants which are included in the Red Book of the Republic of Kazakhstan – Pulsatilla patens (L.) Mill. and Tulipa patens Agardh. ex Schult. f. The data obtained can be used for environmental monitoring and issues of rational nature management of wild plants of Central Kazakhstan.
Decorative perennials of the regional flora for recreation landscapes in the forest-steppe zone
Authors: Matyashuk R. K. , Pirko I. F. , Gubar L. M. , Tkachenko I. V. 
Published: November 2023

This work is devoted to the preservation of biodiversity and the prospects of its integration into projects for the improvement of recreational landscapes and greening facilities of modern cities. It is a continuation of the study of the bioecological potential of regional plant resources for landscaping recreational areas. To represent the existing plant diversity of the forest-steppe zone of Ukraine, a fund of species of decorative perennials was used. At this stage of the research, the decorative and bioecological characteristics of 147 herbaceous perennials of the spontaneous flora of the Feofania tract are given, which determine their economic value. The phenorhythmotypical composition, ecological and cenotic timing, colour spectrum and seasonal colour dynamics were considered. The phenorhythmotypical spectrum of this artificial population is shown, in which long-vegetating species predominate, ensuring the formation of compositions with a closed grass stand and a continuous and long-lasting decorative effect. Critical, from the point of view of competitive relationships, a group of species characterized by active dispersal is identified and options for their optimal use are presented. The ecological and cenotic diversity of the studied population, which is representative for the forest-steppe zone, is shown, which makes it possible to select the optimal multi-component assortment for areas with different ecological conditions. The colour spectrum of the studied group and its dynamics during the growing season, which are comparable for geophilic and sciophilous species, are considered. A conceptual approach to the selection of promising species of regional flora for the creation of decorative locations in city parks is considered. In general, the expediency of using local plant resources as an optimal source of forming a basic assortment of decorative perennials for regional landscaping is shown on the example of the study of some aspects of the aesthetic and bioecological potential of decorative perennials of the spontaneous flora of the Feofania tract. We consider the integration of the existing biodiversity of the regional flora into the architectural environment an important practical component of biodiversity conservation.
Changes in the Carpathian fauna of Malachiinae beetles (Coleoptera, Melyridae) in the context of temperature increase
Authors: Mirutenko V. V. , Lovas P. S. , Roshko V. G. , Felbaba-Klushyna L. M. 
Published: November 2023

Over last century in Europe a tendency of change in species ranges has occurred for insects of different taxonomic groups. We analyzed the changes that have taken place in the distribution of some soft-winged beetles (Malachiinae, Melyridae) species in the Carpathian region. The obtained data are based on a study of museum beetles’ collections and the authors’ collected materials. Data comparison relating to species distribution shows that the Carpathian fauna during the second half of the 20th century increased by 12 species. Some species have significantly changed their ranges. Species of Southern European and Mediterranean (Anthomalachius strangulatus, Clanoptilus spinipennis), Central-East European (Apalochrus femoralis, Clanoptilus falcifer) origin spread to the East Carpathian region. And vice versa, some species (e.g. Malachius scutellaris) from Central European and the Carpathian regions have spread beyond their borders of ranges to the East and North. Malachiinae species are anthophilic insects. Their life cycles, flight period, and distribution depend on the phenology of host plants. Acceleration of phenophases of the host plants and intensification of the metamorphosis processes due to increase in air temperature has caused an earlier appearance of soft-winged beetles in recent years and contributed to expansion of the ranges of some species of them. In our opinion, expansion of the species ranges and penetration of new beetle species into the Carpathian region from surrounding areas are related to the climate changes, in particular to warming. This thesis is confirmed by multiyear air temperature data of the Transcarpathian Centre of Hydrometeorology. On a background of increase in regional air temperature by about 0.8 °C an average air temperature in foothills of Ukrainian Carpathians has increased by 1.7 °C during last 50–60 years.
Role of self-curing mechanism in lightweight concrete: A state-of-the-art report
Authors: Sundaramoorthy Ganesan , Meyyappan Palaniappan 
Published: November 2023

AbstractWorldwide, precast and hybrid construction methods are becoming increasingly popular in the construction industry. But many problems occur during the fabrication, such as segregation, bleeding, scaling, plastic shrinkage, dust formation, honeycombing, sintering, high sorptivity, and high permeability and transportation. This problem may be caused by an ineffective curing process that affects the quality of concrete and construction. In addition, it provides inadequate and incomplete cement hydration that has a 20% negative effect on the desired properties of the concrete. Various researchers have demonstrated the components of self-curing lightweight concrete that can enhance strength and physicochemical properties, and address the above-mentioned issues. In this review, the role of the self-curing mechanism in lightweight concrete based on the various self-curing chemical admixtures such as polyethylene glycol (PEG), superabsorbent polymer (SAP), polyvinyl alcohol (PVA), sodium lignosulfonate and calcium lignosulfonate as self-curing agents are discussed in detail. Also, this paper briefly reports on the scope, significance, mechanisms, and tests for self-curing lightweight concrete. Overall, this review analyzes the possibilities of future research perspectives on self-curing lightweight concrete with sustainable materials and fibres with comparative technical information.