bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical transmission of SARS-CoV-2 – data from the German COVID-19 related obstetric and neonatal outcome study (CRONOS)
Authors: Mand Nadine , Rüdiger Mario , Hütten Matthias , Maier Rolf Felix , Mense Lars , Pecks Ulrich 
Published: January 2024

Abstract

Objectives
We aimed to determine the frequency of SARS-CoV-2 positivity in newborns born to mothers with peripartum SARS-CoV-2 infection in a German cohort, to identify potential risk factors associated with neonatal SARS-CoV-2 infection, and to present short-term outcomes of newborns with vertical transmission of SARS-CoV-2.

Methods
Data on women with SARS-CoV-2 infection occurring anytime during their pregnancy was gathered prospectively within the CRONOS registry. From April 2020 to February 2023 a total of 8,540 women had been registered. The timing and the probability of mother-to-child transmission in neonates born to women with perinatal SARS-CoV-2 infection were classified using the WHO classification system. The severity of maternal infection, maternal vaccination status, type of dominant virus, and perinatal outcome parameters were analyzed as potential risk factors for neonatal SARS-CoV-2 infection.

Results
6.3 % resp. 42.9 % of tested newborns and stillbirths were SARS-CoV-2 positive. 2.1 % of newborns with confirmed and possible SARS-CoV-2 infection were identified. Severe maternal COVID-19 (odds ratio 4.4, 95 % confidence interval 1.8–11.1) and maternal infection with the Delta virus (OR 3.2, 1.4–7.7) were associated with neonatal SARS-CoV-2 infection. Newborns with a confirmed or possible infection were significantly more often admitted to the NICU (65.2 % neonatal infection vs. 27.5 % non, p<0.001).

Conclusions
The rate of neonatal SARS-CoV-2 positivity was higher in our cohort than previously reported, neonatal SARS-CoV-2 infections were rare. Our data emphasizes confirmative testing should be performed in newborns of SARS-CoV-2 infected mothers to identify neonatal SARS-CoV-2 infection as an underlying pathology leading to NICU admission.
From derivation to inflection: the case of the Turkish nominalizer (y)Iş
Authors: Rentzsch Julian 
Published: January 2024

Abstract
The Turkish nominalizer -(y)Iş demonstrates a broad spectrum of functions ranging from a deverbal word-formation device that forms lexicalized nouns with concrete and abstract meanings to an inflectional marker used in nominal clauses, especially in clausal complementation. In some uses, the item conveys manner semantics. While the item itself has been variously investigated and forms an established part of any Turkish grammar description, there is still a lack of consensus on its functional and semantic properties. This article investigates the morphosyntactic functions and the semantic features of the nominalizer -(y)Iş in light of the claims in the linguistic literature on the one hand, which include manner, countable events, factive imperfective, single instance of an event, direct reference to the inner process of an action, etc., and of examples from primary sources on the other, and evaluates the findings from the perspective of grammaticalization. It will be argued that the range of functions of this item and the fact that it seems to resist any straightforward analysis result from its transition from a derivational marker to an inflectional marker with tasks including complementizer functions, a process in which manner semantics will be argued to play a role.
Imaging and spatial omics of kidney injury: significance, challenges, advances and perspectives
Authors: Li Zehua , Lu Yao , Yang Li 
Published: January 2024

Abstract
The kidneys are susceptible to a range of insults that can cause damage to them. Early diagnosis, timely prevention, and proper treatment are crucial for improving the outcome of kidney injury. However, the complexity of renal structure and function makes it difficult to reach the demand of early detection and comprehensive evaluation of kidney injury. No successful drug therapy caused by the elaborate pathogenesis mechanism network of kidney injury calls for a systematical interpretation in mechanism researches. Recent advances in renal imaging and omics studies have provided novel views and deeper insights into kidney injury, but also raise challenges in reaching a comprehensive cellular and molecular atlas of kidney injury. Progresses in imaging and omics of kidney injury are being made in various directions, with the initiative of construction a high-resolution structural atlas of kidney, dynamic and non-invasive evaluation of renal function, and systematic establishment of spatially resolved molecular atlas by transcriptomics and metabolomics. With the limitations of a single modality, novel multimodal integration technologies of imaging and omics are being attempted to achieve a systematic description of nephropathy mechanisms. Further extensive efforts in renal multimodal imaging and omics studies are extremely required to deepen our understanding on kidney injury in the context of diagnostic, mechanistic and therapeutic perspectives.
Light-induced modulation of viscoelastic properties in azobenzene polymers
Authors: Chiodini Stefano , Borbone Fabio , Oscurato Stefano L. , Garcia Pablo D. , Ambrosio Antonio 
Published: January 2024

Abstract
Photo-induced isomerization of azobenzene molecules drives mass migrations in azopolymer samples. The resulting macroscopic directional photo-deformation of the material morphology has found many applications in literature, although the fundamental mechanisms behind this mass transfer are still under debate. Hence, it is of paramount importance to find quantitative observables that could drive the community toward a better understanding of this phenomenon. In this regard, azopolymer mechanical properties have been intensively studied, but the lack of a nanoscale technique capable of quantitative viscoelastic measurements has delayed the progress in the field. Here, we use bimodal atomic force microscopy (AFM) as a powerful technique for nanomechanical characterizations of azopolymers. With this multifrequency AFM approach, we map the azopolymer local elasticity and viscosity, with high resolution, after irradiation. We find that, while in the (previously) illuminated region, a general photo-softening is measured; locally, the Young modulus and the viscosity depend upon the inner structuring of the illuminating light spot. We then propose a possible interpretation based on a light-induced expansion plus a local alignment of the polymer chains (directional hole-burning effect), which explains the experimental observations. The possibility to access, in a reliable and quantitative way, both Young modulus and viscosity could trigger new theoretical–numerical investigations on the azopolymer mass migration dynamics since, as we show, both parameters can be considered measurable. Furthermore, our results provide a route for engineering the nanomechanical properties of azopolymers, which could find interesting applications in cell mechanobiology research.
Plasmonic-based electrochromic materials and devices
Authors: Liu Yuwei , Huang Lin , Cao Sheng , Chen Jingwei , Zou Binsuo , Li Haizeng 
Published: January 2024

Abstract
The development of electrochromic (EC) materials has paved the way for a wide range of devices, such as smart windows, color displays, optical filters, wearable camouflages, among others. However, the advancement of electrochromism faces a significant hurdle due to its poor stability and limited color options. This lack of stability is primarily attributed to the substantial alteration in the dielectric properties of EC materials during cycling. Consequently, the design of advanced plasmonic materials is a key strategy to achieve a stable EC device. In this review, we provide an overview of the current state-of-the-art designs of plasmonic-based EC materials and devices. We discuss their working principles, techniques for structure/morphology engineering, doping methods, and crystal phase design. Furthermore, we explore the integration of plasmonic materials with other EC materials to create advanced EC devices. Finally, we outline the challenges that need to be addressed and present an outlook on the development of high-performance EC devices.
EPIGENETIC ALTERATIONS DRIVING ONCOGENESIS IN HEAD AND NECK SQUAMOUS CELL CARCINOMA
Authors: Yasothkumar D. , Ramalingam K. , Ramani P. 
Published: January 2024

To the Editor,
Head and neck squamous cell carcinoma (HN- SCC) accounts for about 600,000 new cases globally every year and stands the sixth most common cancer, arising from the squamous epithelium. It is localized in the head and neck area involving oral cavity, pharynx, and larynx. Despite the rigorous therapy, the 5-year overall survival remains poor in HNSCC and has not changed appreciably in the last 30 years. The majority of patients develop resistance to chemotherapeutic agents, and cancer progression occurs. Cetuximab, which targets the epidermal growth factor receptor, and pembrolizumab, an anti-programmed-death ligand 1 antibody, are among few FDA-approved medications. Current therapies are poor and cause severe long-term toxicity, which has a long-term impact on the quality of life [1].......
Perception of Physicians’ Notes Among Parents of Different Health Literacy Levels
Authors: Nacht Carrie L. , Jacobson Nora , Shiyanbola Olayinka , Smith Catherine Arnott , Hoonakker Peter L.T. , Coller Ryan J. , Dean Shannon M. , Sklansky Daniel J. , Smith Windy , Sprackling Carley M. , Kelly Michelle M. 
Published: January 2024

OBJECTIVES
To explore the benefits and challenges of accessing physicians’ notes during pediatric hospitalization across parents of different health literacy levels.

METHODS
For this secondary analysis, we used semi-structured interviews conducted with 28 parents on their impressions of having access to their child’s care team notes on a bedside table. Three researchers used thematic analysis to develop a codebook, coded interview data, and identified themes. Parent interviews and respective themes were then dichotomized into proficient or limited health literacy groups and compared.

RESULTS
Nine themes were identified in this secondary analysis: 6 benefits and 3 challenges. All parents identified more benefits than challenges, including that the notes served as a recap of information and memory aid and increased autonomy, empowerment, and advocacy for their child. Both groups disliked receiving bad news in notes before face-to-face communication. Parents with proficient literacy reported that notes allowed them to check information accuracy, but that notes may not be as beneficial for parents with lower health literacy. Parents with limited literacy uniquely identified limited comprehension of medical terms but indicated that notes facilitated their understanding of their child’s condition, increased their appreciation for their health care team, and decreased their anxiety, stress, and worry.

CONCLUSIONS
Parents with limited health literacy uniquely reported that notes improved their understanding of their child’s care and decreased (rather than increased) worry. Reducing medical terminology may be one equitable way to increase note accessibility for parents across the health literacy spectrum.
West Germanic diachronic constant: the case of negative constructions
Authors: Horodilova Tetiana 
Published: January 2024

This paper explores the common path of the sentence negation practice in the Early West Germanic languages. The prior idea is to find out the general set of markers, which implement the negation pattern. Our assumption is that West Germanic languages, as it has been shown in many papers, contrast with East Germanic and North Germanic languages by ways of negation marking. Our aim is to define the status of the grammatical phenomenon in question within the suggested period. Having assumed that all West Germanic languages may share a similar sentence negation pattern, we laid a special emphasis on their structural characteristics. We also hypothesize that gradual changes of this period were occurring due to the general rearrangement of these language system, which incurred the elimination of the redundant elements. According to Jespersen’s cycle, all the languages under consideration faced multiple negation, i.e., the phenomenon of negative concord (NEG-concord). The latter implies the that preverbal negative particles have been removed from the negation pattern both due to their weakening and the rise of the new supportive element, which originated from the independent structural unit wiht ‘thing’. The rise of the supportive element in the Early West Germanic languages is considered to be a part of the Common Germanic NEG-concord pattern. This lexical-grammatical element turned out to be the one that allowed further eliminating the multiple negation practice in West Germanic languages.
Antioxidant Gel from Brown Algae (Ascophyllum nodosum) and Binahong Leaves for Diabetic Wound Healing
Authors: Rahmadianti Salma , Sofianty Irine , Aslamiah Lisa , Insan Febrian Khoirul , Sihombing Maria Engzelita , Nuraini Vidia Afina , Hernawati Hernawati 
Published: January 2024

Background: Diabetic wounds are difficult to treat, causing persistent infections and often leading to limb amputation. One convenient way to manage diabetic wounds is by applying wound dressings. This study aimed to develop a wound dressing in form of a gel containing brown algae and binahong leaf extract for diabetic wound dressings.Methods: This study was an experimental study conducted in the Organic Chemistry Laboratory of Universitas Pendidikan Indonesia from June to September 2022. As many as 33 mice induced by alloxan were divided into 9 groups consisting of application of brown algae extract gel, binahong lead extract gel and a mixture of brown algae, and binahong leaf extract gel with the concentration of 2.5%, 5%, and 10% respectively. All treatments were given within 7 days. Laboratory data collected included phytochemical screening, total phenolic compound, antioxidant activity and organoleptic test.Results: Brown algae and binahong leaf extracts had a high total phenolic content of 331.25 mg GAE/g and 207.01 mg GAE/g, respectively with antioxidant activity of IC50 = 327.33 µg/mL and 209.30 µg/mL, respectively. It was found that brown algae and binahong leaf extracts could accelerate wound closure in a diabetic mouse model. Gel formulation with 10% w/w brown algae extracts presented 91.66% of wound closure, two times greater than treatment with commercial drugs.Conclusion: The developed gel containing brown algae and binahong leaf extracts can be a promising wound dressing for healing diabetic wounds.
Características clínico-epidemiológicas de gestantes com coinfecção HIV/sífilis: revisão integrativa
Authors: Bezerra Janaina Miranda , Ferreira Sannaya da Silva , Carvalho Joênnya Karine Mendes , Nascimento Ana Karoline Lima , Ferreira Adriana Gomes Nogueira , Neto Marcelino Santos 
Published: January 2024

Justificativa e Objetivos: A coinfecção HIV/sífilis é considerada importante agravo durante a gravidez, em razão dos desfechos negativos, como aborto espontâneo, natimortalidade, prematuridade e infecções congênitas. O estudo justifica-se pela necessidade de identificar, nas evidências cientificas, as características clínico-epidemiológicas e vulnerabilidades relacionadas às infecções, fatores que influenciam na prevalência, e agravos relacionados. Objetivou-se sintetizar as evidências científicas acerca de características clínico-epidemiológicas das gestantes com a coinfecção HIV/sífilis no cenário mundial. Conteúdo: trata-se de revisão integrativa da literatura, com busca nas bases de dados PubMed, MEDLINE, CINAHL, LILACS, BDENF e MedCarib, utilizando-se os descritores “HIV”, “Sífilis”, “Epidemiologia”, “Coinfecção” e “Gestante”, combinados pelos operadores booleanos “AND” e “OR”, norteada pela pergunta: quais as evidências científicas relacionadas às características clínico-epidemiológicas das gestantes coinfectadas pelo HIV/sífilis? Realizada de junho a setembro de 2022, incluindo artigos publicados nos últimos oito anos. Selecionaram-se nove artigos primários publicados entre os anos de 2015 e 2020. A associação das infecções esteve presente em gestantes de faixa etária jovem-adulta, raça/cor não branca, casadas, baixo nível de escolaridade, donas de casa, moradoras de áreas urbanas e pertencentes a classes sociais mais desfavorecidas economicamente. Conclusão: evidenciou-se a importância da melhoria na assistência pré-natal, com intuito de reduzir os riscos de transmissão vertical dessas doenças, sobretudo com a implantação de políticas públicas voltadas ao manejo clínico das gestantes coinfectadas, à alocação de recursos e à elaboração de protocolos de intervenção específicos.
Financial Impact of Eliminating a NCAA Division I Men’s Sport on the Athletic Budget: Is Title IX to Blame?
Authors: Marx Anne , Cormier Joel , Ciapalo Roman 
Published: January 2024

The purpose of this study was to examine changes to the budgets of women’s athletics, men’s basketball, and football when an NCAA Division I intercollegiate men’s team was eliminated. Stakeholder theory provided the theoretical framework for the study. Central to the research was the relationship between the elimination of men’s teams and Title IX. Title IX of the Educational Amendments of 1972 is the landmark legislation passed to provide equal educational opportunities for women, including athletics. Eighty-five institutions were included in the study. Data were obtained from the Equity in Athletics Disclosure Act (EADA) for the four years before and after the elimination of a men’s sport between 2007 and 2014, resulting in 15 years of budgetary data. Comparisons of budgets were conducted between the four years prior to when a men’s sport had been cut and the four years after the sport had been eliminated. Analyses indicated that when a men’s sport program had been eliminated, the budget resources of the eliminated program were reallocated primarily to the budgets of men’s basketball and football rather than to the women’s athletics budget. The argument of athletic administrators that decisions to cut programs were based on the need to comply with Title IX was not supported by the data and belied the prevailing view that men’s sports were cut to fund women’s sports in order to comply with Title IX.
CLINICAL ROLE OF miRNA BIOMARKERS IN LARYNGEAL SQUAMOUS CELL CARCINOMA (LSCC): LITERATURE REVIEW
Authors: Rusinowska Barbara , Tybulczuk Balbina 
Published: January 2024

IntroductionMalignant transformations may result from gene dysregulation caused by genetic and epigenetic modifications. The use of miRNAs to treat cancer depends on the downregulation or upregulation of the miRNAs responsible for carcinogenesis (proliferation, angiogenesis, invasion, metastasis), providing the opportunity to suppress tumors. The purpose of this review is to list miRNAs identified so far as biomarkers in laryngeal squamous cell carcinoma (LSCC). This listing may help in predicting the evolution of miRNAs and developing anti-miRNAs and miRNA-mimics as anti-cancer therapies.Material and methodsRelevant publications from 2008 to 2022 were retrieved from the PubMed and Google Scholar databases, using the key words miRNA (PubMed – 149,294 results; Google Scholar – 205,000 results), laryngeal squamous cell carcinoma (PubMed – 33,191 results; Google Scholar – 17,900 results), laryngeal squamous cell carcinoma biomarkers (PubMed – 6249 results; Google Scholar – 18,000 results), laryngeal squamous cell carcinoma miRNA (PubMed – 1338 results; Google Scholar – 17,500 results). Eventually 51 papers were selected for review.ResultsWe identified 51 studies which have detected miRNA-based biomarkers for LSCC, and they are broadly reviewed here.ConclusionsThe identified laryngeal squamous cell-specific miRNA biomarkers appear to be promising for the detection, predicted course, and treatment of LSCC.
NO AFTER-EFFECTS OF COVID-19 INFECTION IN TERMS OF STANDARD AUDIOLOGICAL TESTS
Authors: Apeksha Kumari , DN Gurumallesha , CM Prasad , Basappa Ananya 
Published: January 2024

IntroductionCoronavirus disease (COVID-19), considered to be caused by a novel coronavirus (SARS-CoV-2), is an acute respiratory disease which was declared a pandemic by the World Health Organization. Previously published reports have shown contradictory findings on the
involvement of the auditory system in individuals infected with COVID-19. The present study aims to assess auditory system functioning in individuals post-COVID-19 infection and compare the results with individuals without COVID-19 infection.Material and methodsParticipants in this study were 30 individuals who had experienced mild COVID-19 infection and 30 individuals who never had COVID-19. Participants were aged between 18 and 40 years. Testing was done 1 to 6 months after infection, and involved conventional and extended high-frequency audiometry, speech perception in quiet and at different signal-to-noise ratios (SPIN), transient evoked otoacoustic emissions (TEOAEs) in quiet and in the presence of contralateral noise, and auditory brainstem response (ABR) in the ipsilateral and contralateral mode.ResultsNone of the tests – pure-tone thresholds, speech perception in quiet and in noise, TEOAE with and without contralateral noise, and ABR – showed any significant difference between individuals who never had COVID-19 infection and those who had recovered from the
infection. Both afferent and efferent auditory pathways showed normal findings in individuals post-COVID-19 infection.ConclusionsIndividuals who have been infected with mild COVID-19 did not show any significant deficit in any of the audiological tests, suggesting that the disease does not cause any permanent harm to the auditory system after the infection has subsided.
NORMATIVE VALUES OF NASAL RESONANCE: PRELIMINARY DATA FOR POLISH WORKING-AGE ADULTS
Authors: Krasnodębska Paulina , Miaśkiewicz Beata , Milewska Marzena , Będziński Wojciech , Szkiełkowska Agata , Skarżyński Henryk 
Published: January 2024

IntroductionEvaluation of nasal resonance is an important part of everyday otolaryngological, phoniatric, and speech therapy practice. It allows the detection and monitoring of anatomical and functional abnormalities in the nasal and oropharyngeal cavities. Nasal resonance
can be objectively measured by assessing acoustic energy emitted by each of the subject’s nose and mouth. The ratio is called nasalance. The aim of this study was to develop normative values of nasal resonance on a digital device while adults were reading aloud Polish-language material.Material and methodsThe study included 51 patients. Patients were tested with three language tests developed by Gąsiorek in 1996. Nasal resonance was measured using a Nasometer II (Model 6450) from Pentax Medical.ResultsThe mean nasalance in the vowel test was 18.8% (SD = 7.8%). The mean nasalance during the test based on sentences was 14.3% (SD = 4.0%), and for reading continuous text it was 11.7% (SD = 3.7%). Statistical analysis showed no significant difference between men and women on each test. The limiting normative value for nasalance was determined to be 20% in the sentence test (test III of Gąsiorek 1996).Conclusions1. Preliminary normative values of nasal resonance for Polish adults have been established based on current methodology.
2. Language tests developed and already in use can be applied to modern digital devices.