bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noetherian spectrum condition and the ring 𝒜[X]
Authors: Guesmi Samir , Hamed Ahmed 
Published: October 2023

Let [Formula: see text] be an ascending chain of commutative rings with identity and let [Formula: see text] be the ring of polynomials with coefficient of degree [Formula: see text] in [Formula: see text] for each [Formula: see text] In the first part of this paper, we give a necessary and sufficient conditions for the ring [Formula: see text] to satisfy Noetherian spectrum (a ring [Formula: see text] is said to have Noetherian spectrum if [Formula: see text] satisfies the Ascending Chain Condition (ACC) on radical ideals). In particular, we extend classical results proved by Ohm and Pendleton in [J. Ohm and R. Pendleton, Rings with Noetherian spectrum, Duke Math. J. 35 (1968) 631–639] and by Hizem in [S. Hizem, Chain conditions in rings of the form A + XB[X] and A + XI[X], in Commutative Algebra and its Applications (de Gruyter, 2009), pp. 259–274]. The second part of this paper is motivated by the interesting results proved on uniformly [Formula: see text]-Noetherian rings by Kim et al. in [W. Qi, H. Kim, F. Wang, M. Chen and W. Zhao, Uniformly S-Noetherian rings (submitted)]. We introduce the concept of uniformly [Formula: see text]-Noetherian spectrum and study its properties. Let [Formula: see text] be a commutative ring and [Formula: see text] a multiplicative subset of [Formula: see text] We say that [Formula: see text] has uniformly S-Noetherian spectrum if that there exists an [Formula: see text] such that for any ideal [Formula: see text] of [Formula: see text], [Formula: see text] for some finitely generated subideal [Formula: see text] of [Formula: see text] We give the Eakin–Nagata–Formanek theorem for the uniformly [Formula: see text]-Noetherian spectrum condition. We also study the uniformly [Formula: see text]-Noetherian uniformly properties on several ring constructions (Nagata’s idealization and amalgamated algebras).
Dendrobium officinale Polysaccharides Inhibit CDCA-Induced Gastric Intestinal Metaplasia through Activating NRF2/HO-1 and Modulating HNF4α/CDX2 Signaling Pathway
Authors: Zhao Yi , Huang Hongxia , Wang Xinnan , Hu Wenxiu , Lu Xuefeng , Tang Suyuan , Liu Hongning , Sun Youzhi 
Published: October 2023

Bile reflux (BR) was considered to be an independent risk factor for the development of precancerous gastric lesions and GC. Dendrobium officinale polysaccharides (DOP) show a novel potential in preventing the progress of gastric cancer. However, the specific mechanism of DOP that causes such activities remains a mystery. This study aimed to investigate the effects of DOP on chenodeoxycholic acid (CDCA)-induced gastric intestinal metaplasia and explore the underlying mechanisms. Different concentrations of DOP had no significant damage to normal GSE-1 cells and gastric intestinal metaplasia model cells by CCK-8 assay. After DOP treatment, the mRNA and protein expression of CDX2 (

p

< 0.01) and HNF4α (

p

< 0.01) were decreased, and HO-1 (

p

< 0.05) and TFF2 (

p

< 0.01) were increased. The NRF2 protein expression was slightly upregulated (

p

< 0.05), and H-DOP further promoted NRF2 protein expression in the nucleus (

p

< 0.05). Hence, our findings reveal that DOP could be used as a potential anti-inflammation supplement by activating NRF2/HO-1 and modulating the HNF4α/CDX2 signaling pathway to inhibit the progress of CDCA-induced gastric intestinal metaplasia.
Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy
Authors: Zila Nina , Eichhoff Ossia M. , Steiner Irene , Mohr Thomas , Bileck Andrea , Cheng Phil F. , Leitner Alexander , Gillet Ludovic , Sajic Tatjana , Goetze Sandra , Friedrich Betty , Bortel Patricia , Strobl Johanna , Reitermaier René , Hogan Sabrina A. , Martínez Gómez Julia M. , Staeger Ramon , Tuchmann Felix , Peters Sophie , Stary Georg , Kuttke Mario , Elbe-Bürger Adelheid , Hoeller Christoph , Kunstfeld Rainer , Weninger Wolfgang , Wollscheid Bernd , Dummer Reinhard , French Lars E. , Gerner Christopher , Aebersold Ruedi , Levesque Mitchell P. , Paulitschke Verena 
Published: October 2023

Abstract

Purpose:
Despite high clinical need, there are no biomarkers that accurately predict the response of patients with metastatic melanoma to anti-PD-1 therapy.

Experimental Design:
In this multicenter study, we applied protein depletion and enrichment methods prior to various proteomic techniques to analyze a serum discovery cohort (n = 56) and three independent serum validation cohorts (n = 80, n = 12, n = 17). Further validation analyses by literature and survival analysis followed.

Results:
We identified several significantly regulated proteins as well as biological processes such as neutrophil degranulation, cell–substrate adhesion, and extracellular matrix organization. Analysis of the three independent serum validation cohorts confirmed the significant differences between responders (R) and nonresponders (NR) observed in the initial discovery cohort. In addition, literature-based validation highlighted 30 markers overlapping with previously published signatures. Survival analysis using the TCGA database showed that overexpression of 17 of the markers we identified correlated with lower overall survival in patients with melanoma.

Conclusions:
Ultimately, this multilayered serum analysis led to a potential marker signature with 10 key markers significantly altered in at least two independent serum cohorts: CRP, LYVE1, SAA2, C1RL, CFHR3, LBP, LDHB, S100A8, S100A9, and SAA1, which will serve as the basis for further investigation. In addition to patient serum, we analyzed primary melanoma tumor cells from NR and found a potential marker signature with four key markers: LAMC1, PXDN, SERPINE1, and VCAN.
Preventive Treatment with PD-1 Antibody Increases Tissue-resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis
Authors: Xiao Zeru , Yan Rui , Liu Heshu , Huang Xuying , Liang Ziwei , An Guangyu , Ge Yang 
Published: October 2023

Abstract

Numerous studies and clinical trials have shown that immune checkpoint inhibitors can effectively prevent tumor growth and metastasis in esophageal squamous cell carcinoma (ESCC) patients. In this study, we aimed to evaluate the anti-tumor effects of PD-1 antibody preventive treatment in patients with early stages ESCC as well as patients with high-grade intraepithelial neoplasia (HGIN). We first established an ESCC model using C57BL/6J mice treated with the chemical carcinogen 4- NQO and observed esophageal lesions at different time points. Second, we compared the antitumor efficacy of PD-1 antibody treatment in mice at the ESCC stage and PD-1 antibody preventive treatment in mice at the HGIN stage. The results showed that PD-1 antibody preventive treatment effectively impeded the progression of 4NQO-induced esophageal tumorigenesis. IHC analysis was performed to observe the infiltration of immune cells into the tumor microenvironment. It has been shown that active tissue-resident memory T cells can be induced and resided into the tumor microenvironment for a long period after treatment with PD-1 antibody. Reexposure to the oncogenic environment colonized by CD8+TRM cells can still exert antitumor effects. These results provide new strategies for the treatment of patients with early stage ESCC and HGIN.

Prevention Relevance:
Immune checkpoint inhibitors have shown promising results in multiple tumor species. However, there is currently no clinical application to evaluate their therapeutic value in cancer preventive treatment. Prophylactic use of immune checkpoint inhibitors in the early stages of ESCC may provide long-term benefits to patients.
Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study
Authors: Kelly William K. , Danila Daniel C. , Lin Chia-Chi , Lee Jae-Lyun , Matsubara Nobuaki , Ward Patrick J. , Armstrong Andrew J. , Pook David , Kim Miso , Dorff Tanya B. , Fischer Stefanie , Lin Yung-Chang , Horvath Lisa G. , Sumey Christopher , Yang Zhao , Jurida Gabor , Smith Kristen M. , Connarn Jamie N. , Penny Hweixian L. , Stieglmaier Julia , Appleman Leonard J. 
Published: October 2023

AbstractXaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)–targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer. This first-in-human study reports monotherapy dose exploration for patients with metastatic castration-resistant prostate cancer (mCRPC), primarily taxane pretreated. Ninety-seven patients received ≥1 intravenous dose ranging from 0.001 to 2.0 mg weekly or every 2 weeks. MTD was identified as 1.5 mg i.v. weekly via a 3-step dose. The most common treatment-related adverse events were cytokine release syndrome (CRS; 72%), fatigue (45%), and myalgia (34%). CRS occurred primarily during cycle 1 and improved with premedication and step dosing. Prostate-specific antigen (PSA) and RECIST responses across cohorts were encouraging [49% PSA50; 24% objective response rate (ORR)], with greater frequency at target doses ≥0.75 mg (59% PSA50; 41% ORR). Xaluritamig is a novel immunotherapy for prostate cancer that has shown encouraging results supporting further development.Significance:Xaluritamig demonstrated encouraging responses (PSA and RECIST) compared with historical established treatments for patients with late-line mCRPC. This study provides proof of concept for T-cell engagers as a potential treatment for prostate cancer, validates STEAP1 as a target, and supports further clinical investigation of xaluritamig in prostate cancer.See related commentary by Hage Chehade et al., p. 20.See related article by Nolan-Stevaux et al., p. 90.This article is featured in Selected Articles from This Issue, p. 5
T
2
-NER: A

T

wo-Stage Span-Based Framework for Unified Named Entity Recognition with

T

emplates
Authors: Huang Peixin , Zhao Xiang , Hu Minghao , Tan Zhen , Xiao Weidong 
Published: October 2023

Abstract
Named Entity Recognition (NER) has so far evolved from the traditional flat NER to overlapped and discontinuous NER. They have mostly been solved separately, with only several exceptions that concurrently tackle three tasks with a single model. The current best-performing method formalizes the unified NER as word-word relation classification, which barely focuses on mention content learning and fails to detect entity mentions comprising a single word. In this paper, we propose a two-stage span-based framework with templates, namely, T2-NER, to resolve the unified NER task. The first stage is to extract entity spans, where flat and overlapped entities can be recognized. The second stage is to classify over all entity span pairs, where discontinuous entities can be recognized. Finally, multi-task learning is used to jointly train two stages. To improve the efficiency of span-based model, we design grouped templates and typed templates for two stages to realize batch computations. We also apply an adjacent packing strategy and a latter packing strategy to model discriminative boundary information and learn better span (pair) representation. Moreover, we introduce the syntax information to enhance our span representation. We perform extensive experiments on eight benchmark datasets for flat, overlapped, and discontinuous NER, where our model beats all the current competitive baselines, obtaining the best performance of unified NER.
Incidence and diversity of plant-parasitic nematodes associated with wheat-cropping systems in the inner part of the Aegean Region of Turkey
Authors: Acan Hacer , Yüksel Ebubekir , Duman Nagihan , Öcal Atilla , Dinçer Dilek , Bozbuğa Refik , Yildiz Şenol , Laasli Salah-Eddine , Amer Mohammed , Canhilal Ramazan , Dababat Abdelfattah , İmren Mustafa 
Published: October 2023

Summary
Plant-parasitic nematodes are among the most influential soil organisms worldwide and have a detrimental impact on wheat productivity; they also play a major role in maintaining soil diversity. However, limited information is available on the biodiversity of nematodes associated with wheat cropping systems in Turkey. To address this knowledge gap, 45 wheat fields in the Afyonkarahisar Province of Turkey were sampled in 2021 in order to extract and identify nematodes. A total of 14 genera and 44 species of these nematodes were identified based on their physical traits and ITS DNA sequences examination. Shannon diversity index was used to determine the prevalence and biodiversity features of these nematodes. This study represents the first comprehensive research on plant-parasitic nematodes from wheat-growing regions in the Afyonkarahisar Province. The genera Helicotylenchus, Heterodera, Merlinius, Pratylenchoides and Pratylenchus dominated with a high relative abundance percentage >60%, and were extremely common (>90% for each). The average Shannon index of nematode species in the wheat fields was 2.20, with an evenness value of 0.81, indicating moderate diversification and good nematode evenness. This study also revealed a significant correlation between nematode genus biodiversity and edaphic, climatic and geographical factors. Finally, this research demonstrated a remarkable diversity of soil nematodes associated with wheat crops and they have the potential to be useful tools for extensive soil bio-study.
A comparison of tablet-based and paper-based venous insufficiency epidemiologic and economic study quality of life/symptom questionnaire for assessment of chronic venous disease
Authors: Albernaz Luiz Fernando , Albernaz Daiane Taís Schlindwein , Zignani Fernanda Rita , Santiago Fabricio , de Moura Regina Marcia Faria , Barroso Gustavo , Reis e Silva Alexandre , Chi Yung-Wei 
Published: October 2023

Objective To comparatively evaluate performances of tablet-based versus paper-based Venous Insufficiency Epidemiologic and Economic Study-Quality of Life/Symptom (VEINES-QOL/Sym) questionnaire. Methods We prospectively evaluated 78 consecutive patients who completed tablet-based and paper-based VEINES-QOL/Sym questionnaires and compared their scores, completion time, data entry time, and ease of use. We used Student’s t-test and Wilcoxon test for quantitative variables, Bland–Altman test and kappa coefficient for agreement between questionnaires and patients, respectively. Spearman’s correlation coefficient was used to assess correlations. Results Most participants (83.3%) found it easier to use the tablet device. Less time was needed to complete the tablet-based (median, 4.75; IQR, 3–7 min) than the paper-based (median, 8.3; IQR, 6.3–11.3 min) questionnaire ( p < .001). Better educated patients took less time to complete paper-based ( p = .003) and tablet-based ( p = .001) questionnaires and considered the latter easier to use ( p = .010). Conclusions The tablet-based VEINES-QOL/Sym proved to be an easy-to-use and time-saving tool.
Comparison of the mid-term clinical efficacy of different fixtaion methods combined with oblique lumbar interbody fusion in treating lumbar degenerative diseases
Authors: Yu Yang , Wang Yongtao , Xie Yizhou , Feng Chengzhi , Chen Yuzhou , Xu Jiajia , Fan Xiaohong 
Published: October 2023

Background To compare the mid-term follow-up clinical efficacy among three treatment approaches for lumbar degenerative diseases (LDD): standalone oblique lumbar interbody fusion (SF), oblique lumbar interbody fusion combined with lateral screw fixation (LF), and oblique lumbar interbody fusion combined with posterior screw fixation (PF). Method This retrospective study included a total of 71 cases of single level LDD that underwent OLIF in Hospital of Chengdu University of Traditional Chinese Medicine were retrospectively collected between March 2016 and September 2017. Patients were divided into three groups: 24 cases in the SF group, 24 cases in the LF group and 23 cases in the PF group. Various parameters, such as operation time, hospitalization time, and complications, were recorded. The fusion condition was assessed at last follow up. Clinical outcomes were evaluated using the Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) from pre-operation to 5 years post-surgery. Results Significantly lower mean operation time and hospitalization time were observed in the SF and LF groups compared to the PF group ( p < .05). However, no significant difference in fusion rate was found among the three groups. Regarding clinical outcomes, there was no statistically significant difference in VAS scores between the three groups during all follow-up periods. At the 6th month and 1st year after surgery, the SF and LF groups had significantly lower Oswestry Disability Index (ODI) scores compared to the PF group ( p < .05). There was no significant difference in perioperative complication rates among the three groups ( p > .05). In the LF group, one case of instrument displacement and urethra injury were reported, while in the SF, LF, and PF groups, 10, 9, and 3 cases of cage subsidence were reported, respectively. Conclusion The study findings suggest that oblique lumbar interbody fusion (OLIF) is a safe and effective treatment for mid-term management of lumbar degenerative diseases (LDD). Compared to the posterior screw fixation (PF) group, both the standalone OLIF (SF) and OLIF combined with lateral screw fixation (LF) groups showed advantages in terms of reduced operation time, shorter hospitalization, and faster symptom alleviation in the short-term. However, OLIF combined with PF demonstrated comparable symptom relief in the mid-term and had the additional benefit of lower cage subsidence rates while improving fusion rates as well.
Towards Building a More Diverse, Equitable, and Inclusive Society: Interactive Sessions with the HFES Csouncil of Affinity Group (COAG) Leads
Authors: Bruni Sylvain , Lum Heather C. , Figueroa-Jacinto Rosemarie , Jeon Myounghoon , Barton Hanna J. , Kim Ji-Eun 
Published: October 2023

Human Factors and Ergonomics (HF/E) professionals, as part of their job, are required to consider the differences and varying perspectives of their human stakeholders (e.g., users, customers, teammates, sponsors). Beyond the performance of purely HF/E methodologies, practicing empathy and engaging with affinity groups (AGs) are recognized methods for researchers, designers, engineers, or product managers to achieve such understanding. In this two-part panel, the leaders of AGs and of the Council of Affinity Group (COAG) of the Human Factors and Ergonomics Society (HFES) will engage with the audience in conversational and interactive sessions aimed at both discussing and practicing empathy and engagement with community groups including AGs. The first session will be focused on experiential learning through interactive exercises. The second session will be reflective in nature and oriented toward follow-on actions and behavior change within and outside HFES. The sessions are expected to promote DEI in our HFES community and beyond. Discussion time: Two sessions (90 minutes each), one at the beginning of the conference and the second toward the end of the conference.
Construction of Human Digital Twin Model Based on Multimodal Data and Its Application in Locomotion Mode Identification
Authors: Zhong Ruirui , Hu Bingtao , Feng Yixiong , Zheng Hao , Hong Zhaoxi , Lou Shanhe , Tan Jianrong 
Published: October 2023

AbstractWith the increasing attention to the state and role of people in intelligent manufacturing, there is a strong demand for human-cyber-physical systems (HCPS) that focus on human-robot interaction. The existing intelligent manufacturing system cannot satisfy efficient human-robot collaborative work. However, unlike machines equipped with sensors, human characteristic information is difficult to be perceived and digitized instantly. In view of the high complexity and uncertainty of the human body, this paper proposes a framework for building a human digital twin (HDT) model based on multimodal data and expounds on the key technologies. Data acquisition system is built to dynamically acquire and update the body state data and physiological data of the human body and realize the digital expression of multi-source heterogeneous human body information. A bidirectional long short-term memory and convolutional neural network (BiLSTM-CNN) based network is devised to fuse multimodal human data and extract the spatiotemporal features, and the human locomotion mode identification is taken as an application case. A series of optimization experiments are carried out to improve the performance of the proposed BiLSTM-CNN-based network model. The proposed model is compared with traditional locomotion mode identification models. The experimental results proved the superiority of the HDT framework for human locomotion mode identification.
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
Authors: Zhang Xiuyan , Wang Yu , Lu Jinchang , Xiao Lun , Chen Hui , Li Quanxue , Li Yuan-Yuan , Xu Peng , Ruan Changgeng , Zhou Haixia , Zhao Yun 
Published: October 2023

Abstract
Background
Zinc finger protein X-linked (ZFX) has been shown to promote the growth of tumor cells, including leukemic cells. However, the role of ZFX in the growth and drug response of chronic myeloid leukemia (CML) stem/progenitor cells remains unclear.

Methods
Real-time quantitative PCR (RT–qPCR) and immunofluorescence were used to analyze the expression of ZFX and WNT3 in CML CD34+ cells compared with normal control cells. Short hairpin RNAs (shRNAs) and clustered regularly interspaced short palindromic repeats/dead CRISPR-associated protein 9 (CRISPR/dCas9) technologies were used to study the role of ZFX in growth and drug response of CML cells. Microarray data were generated to compare ZFX-silenced CML CD34+ cells with their controls. Chromatin immunoprecipitation (ChIP) and luciferase reporter assays were performed to study the molecular mechanisms of ZFX to regulate WNT3 expression. RT–qPCR and western blotting were used to study the effect of ZFX on β-catenin signaling.

Results
We showed that ZFX expression was significantly higher in CML CD34+ cells than in control cells. Overexpression and gene silencing experiments indicated that ZFX promoted the in vitro growth of CML cells, conferred imatinib mesylate (IM) resistance to these cells, and enhanced BCR/ABL-induced malignant transformation. Microarray data and subsequent validation revealed that WNT3 transcription was conservatively regulated by ZFX. WNT3 was highly expressed in CML CD34+ cells, and WNT3 regulated the growth and IM response of these cells similarly to ZFX. Moreover, WNT3 overexpression partially rescued ZFX silencing-induced growth inhibition and IM hypersensitivity. ZFX silencing decreased WNT3/β-catenin signaling, including c-MYC and CCND1 expression.

Conclusion
The present study identified a novel ZFX/WNT3 axis that modulates the growth and IM response of CML stem/progenitor cells.