bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of polyphenols in the prevention and treatment of cancer
Authors: Szypuła Aleksandra , Michalik Beniamin , Galasińska Iwona , Hajduk-Maślak Katarzyna , Skóra Adrianna , Sęk Michał 
Published: February 2024

Introduction: Polyphenolic compounds are widespread in nature, contained in large quantities especially in fruits, vegetables, cereals and nuts. In recent years numerous attempts have been made to characterize their biological effects, with particular emphasis on their protective potential against the development of chronic diseases, including cancer.
Purpose of the study: The aim of the study was to collect and analyze publications on the use of polyphenols in the prevention and treatment of cancer, with particular emphasis on breast cancer, colon cancer, prostate cancer and lung cancer - the four most common cancers in the Polish population.
Material and methods: A review of the literature available on PubMed was performed using various combinations of keywords: 'polyphenols' + 'cancer', 'polyphenols' + 'oncology', ‘polyphenols’ + ‘chemoprevention’, ‘polyphenols’ + ‘chemotherapy’, 'polyphenols' + 'lung cancer', 'polyphenols' + 'breast cancer', ‘polyphenols’ + ‘colorectal cancer’, 'polyphenols' + 'prostate cancer'/'prostate gland cancer'.
Results: The analysis of the collected publications allows to conclude that polyphenols exert multidirectional anticancer effect through antioxidant, antiproliferative, anti-inflammatory, immunomodulatory and prosenescence activity. This effect has been demonstrated, among others, in relation to cellular models of colorectal cancer, prostate cancer, breast cancer, cervical cancer and lung cancer. Polyphenols also reduce side effects associated with the use of conventional anticancer therapies and increase their effectiveness.
Conclusions: Polyphenols - both as independent compounds and components of complex anticancer treatment regimens - have chemopreventive and potentially chemotherapeutic effects. By influencing various stages of carcinogenesis - initiation, promotion and progression of cancer - they constitute a promising direction for the development of new, more effective forms of therapy and prevention of cancer.
The multimodal approach to obesity treatment – current pharmacological and surgical methods and lifestyle changes
Authors: Kowalczuk Maria , Lipińska Justyna , Kopeć Izabela , Lipiński Łukasz , Kamiński Jakub , Klimczak Klaudia , Loryś Laura , Narloch Marcin , Kasprzak Stanisław , Kasprzak Karolina 
Published: February 2024

Introduction
Obesity is one of the major health problems of today’s population and is defined as a body mass index ≥ 30 kg/m2. It is known that obesity may cause many complications such as type 2 diabetes, cardiovascular disease, osteoarthritis, obstructive sleep, apnoea, and several cancers. The only effective treatment of obesity can be pharmacological or surgical, especially when a years-long attempt to change habits has had no effects.
Aim of the study
This review aims to present the current state of knowledge about non-pharmacological and pharmacological obesity treatment methods.
Materials and methods
The paper was created based on the Pubmed database. The literature was reviewed using the keywords: ”obesity”, ”obesity treatment”, “ obesity lifestyle changes”, “obesity medications” and ”obesity surgery”.
The current state of knowledge
The treatment of obesity requires a multimodal approach to treatment, including the addition of anti-obesity medications or bariatric surgery, or both, to assist people in reaching and sustaining sufficient weight loss to meet treatment goals. The 3 principal components of a comprehensive lifestyle intervention are diet, physical activity, and behavioral therapy. Among available anti-obesity medications include orlistat, phentermine, topiramate, naltrexone, bupropion, liraglutide, and semaglutide.
Summary
The key challenge in the treatment of obesity is to maintain the effects obtained with multimodal therapy. Without proper motivation of patients and changes in eating and behavioral habits, it is impossible to achieve optimal results, therefore, in addition to medical interventions, more and more attention should be paid to psychological interventions.
The effect of air pollution on the risk of inflammatory bowel disease, colorectal cancer and appendicitis
Authors: Król Dominika , Sak Justyna , Mazurkiewicz Wojciech , Nowiński Michał , Fus-Mazurkiewicz Laura 
Published: February 2024

Introduction and objective
Intense industrial development is contributing to increased emissions of air pollutants. Numerous studies indicate a link between air pollution and a higher risk of pulmonary and cardiovascular diseases. Our goal is to analyze available scientific studies to demonstrate the relationship between air pollution and the risk of developing and complicating inflammatory bowel disease, colorectal cancer and appendicitis.
Brief description of the state of knowledge
Air pollution is a global health challenge. Particles such as PM, nitrogen oxides, sulfur oxides or ozone have a significant impact on health. Studies suggest a link between pollution and intestinal diseases (IBD, CRC, appendicitis). Air pollutants can affect the gut by causing inflammation, oxidative stress and disruption of the gut microbiota. Exposure to PM2.5 can increase the risk of IBD, CRC, and PM10 can increase the risk of UC. There is a correlation between pollution and the rate of hospitalization for IBD. In addition, exposure to PM2.5 increases the risk of colorectal cancer mortality. Short-term exposure to air pollution is associated with more hospitalizations for appendicitis.
Summary
Air pollution is a real health risk. Reducing air pollution could potentially reduce the risk of developing these intestinal diseases and their complications. Despite the potential links, further research is required to better understand the mechanisms of action of pollutants on intestinal health. Urgent and coordinated global and local action is needed to reduce air pollution emissions and protect the health of the public.
Pollen food syndrome: learning from a case series
Authors: Dobson Marianne Louise , Steele Cathal Laurence , Theaker Elizabeth Diana 
Published: February 2024

Pollen food syndrome (PFS) is an IgE-mediated food hypersensitivity reaction that typically results in immediate-onset oral and oropharyngeal symptoms in individuals who are sensitized to pollen. Symptoms are often mild, but systemic allergic reactions, including anaphylaxis, occur rarely. Using a cases series of six patients who were referred to our oral medicine department and for whom a diagnosis of PFS was made, we illustrate the clinical features of PFS and discuss the possibility that oral mucosal lesions may be a feature. Patients with PFS (or indeed other food hypersensitivities) may present to dental professionals in the first instance, therefore, it is important to be able to recognize key signs/symptoms, to give advice and to investigate/refer appropriately. CPD/Clinical Relevance: Awareness of the clinical features of PFS, including oral mucosal lesions, is of value to dental clinicians
De com un geògraf català urbanita intenta explicar què són les ruralies
Authors: Mendizàbal Enric 
Published: February 2024

L’objectiu d’aquest text és reflexionar sobre els conceptes de ruralia, ruralitat i rural des de la geografia utilitzant com a exemple el Pirineu català, del qual es mostrenels canvis i les transformacions des de l’inici del segle xviii, però sobretot en el període1950-2023, en què es pot observar que el món pagès tradicional es va convertint en un món rural on es poden trobar les característiques de la vida urbana. En l’apartat final es mostra la importància de la frase d’Ildefons Cerdà «rurizad lo urbano: urbanizad lo rural », que exemplifica el que succeeix actualment en les relacions rurals i urbanes.
Novel hormonal therapy versus standard of care—A registry-based comparative effectiveness evaluation for mCRPC-patients
Authors: Jonéus Paulina , Johansson Per , Langenskiöld Sophie 
Published: February 2024

Background
This paper presents results from one of the few comparative effectiveness evaluations of novel antiandrogen medications (NHT) against standard of care (SoC) for patients suffering from metastatic castrate-resistant prostate cancer (mCRPC).

Methods
The design and the analysis are published in a protocol before accessing outcome data. Two groups of patients are balanced on hundreds of important covariates measured before the prostate cancer diagnosis and up to the date of the prescription. While the design yields balance on the observed covariates, one cannot discard the possibility that unobserved confounders are not balanced. The unconfoundedness assumption is assessed by estimating placebo regressions on two health measures, not included in the design but added together with the outcome data after protocol publication.

Results
We find a substantial (64 percent) increase in mortality for patients prescribed with NHT rather than SoC. However, based on the results from one of the two placebo regressions, we cannot rule out that the difference in mortality may be due to confounding. Using a bounding strategy of the effect, we can, however, rule out that NHT reduces mortality compared to SoC. Under an empirical valid assumption that most mCRPC patients who die suffer from bone metastases, we have a strong indication of increased skeleton-related events in patients if prescribed NHT against SoC.

Conclusions
Generally, the SoC for this group of patients is docetaxel. Given the substantially higher costs of many of the NHT, the finding of no positive effects from NHT on both mortality and SRE is important. More comparative studies, including studies analysing quality of life outcomes, are thus needed.
Dietary intake is associated with the prevalence of uterine leiomyoma in Korean women: A retrospective cohort study
Authors: Kim Min-Jeong , Kim Sunmie , Kim Jin Ju , Kim Young Sun , Song Ji Hyun , Lee Jung Eun , Youn Jiyoung , Yang Sun Young 
Published: February 2024

Objective
Uterine leiomyoma (UL), the most prevalent benign gynecologic tumor among reproductive-aged women, lacks sufficient research on the potential association between dietary intake and its occurrence in Korean women. Addressing this research gap, this study aims to evaluate the potential link between dietary intake and the prevalence of UL in Korean women.

Methods
In this cross-sectional study, a cohort of 672 women, aged 23 to 73, were enrolled, with 383 (57%) being premenopausal. Dietary intake was assessed using a validated food frequency questionnaire (FFQ), and UL presence was determined through ultrasonography. The analysis focused exclusively on items within ten categories, including vegetables/fruit, vegetables, fruits, red meat, processed meat, poultry, fish, dairy product, milk, and alcohol. Multiple logistic regression models were employed to explore the relationship between dietary intake and the prevalence of UL, calculating odds ratios (ORs) and 95% confidence intervals (CIs) while adjusting for confounding factors.

Results
Within the total cohort, 220 (32.7%) women were diagnosed with UL. High intakes of fish and poultry showed an association with higher UL prevalence. Odds ratios (95% CIs) for the upper quartiles compared to the lower quartiles were 1.68 (1.01–2.81; p trend = 0.05) for fish intake and 1.87 (1.11–3.17; p trend = 0.06) for poultry intake. Conversely, an inverse relationship emerged between dairy product intake and UL prevalence, with an odds ratio of 0.58 (95% CI 0.35–0.96; p trend = 0.05). Stratifying the analysis by menopausal status revealed a parallel pattern, with heightened UL prevalence with fish intake and reduced prevalence with dairy product intake. However, the link between poultry intake and UL prevalence was primarily observed among postmenopausal women. Among premenopausal women, elevated vegetable intake was linked to a decreased UL prevalence (OR 0.45, 95% CI 0.21–0.97 for top vs. bottom quartiles; p trend = 0.01).

Conclusion
We found that high consumption of fish and poultry, coupled with low intake of dairy products, correlated with an elevated prevalence of UL. Furthermore, vegetable intake exhibited an inverse relationship with UL prevalence, particularly among premenopausal women.
Self-reporting of hearing loss and tinnitus in the diagnosis of ototoxicity by meglumine antimoniate in patients treated for American tegumentary Leishmaniasis
Authors: Duarte Claudia Cristina Jardim , Torraca Tania Salgado de Sousa , Bezerra Débora de Oliveira , Oliveira Renata de Barcelos , Leite Nayany Kerollyany Sousa , de Oliveira Raquel de Vasconcellos Carvalhaes , Araújo-Melo Maria Helena , Pimentel Maria Inês Fernandes , Costa Ananda Dutra da , Vasconcellos Érica de Camargo Ferreira , Lyra Marcelo Rosandiski , Soares Ester Cleisla dos Anjos , Paes Lúcia Regina do Nascimento Brahim , Salgueiro Mariza Mattos , Schubach Armando de Oliveira , Valete Cláudia Maria 
Published: February 2024

Introduction
American Tegumentary Leishmaniasis (ATL) treatment is based on pentavalent antimonials (Sb5+), but these drugs have been associated to several adverse effects. Hearing loss and tinnitus during treatment with meglumine antimoniate (MA) have already been reported. This study aimed to describe the usefulness of self-reporting of hearing loss and tinnitus in diagnosing MA-induced ototoxicity.

Methods
A prospective longitudinal study was conducted with 102 patients with parasitological diagnosis of ATL, treated with different MA schemes. The presence of clinical auditory toxicity was defined as the emergence or worsening of self-reporting hearing loss and/or tinnitus during monitoring. Measures of sensitivity, specificity, and the positive and negative predictive value of the patient’s self-reporting of hearing loss and tinnitus in relation to the result of the audiometric test (considered the gold standard) were calculated.

Results
The age of the evaluated patients ranged from 15 to 81 years, with a median of 41 years, and most were male (73.5%). Seventy-five patients (73.5%) had cutaneous leishmaniasis and 27 (26.5%) mucosal leishmaniasis. Eighty-six patients (84.3%) received intramuscular (IM) treatment and 16 (15.7%) were treated with intralesional MA. During treatment, 18 (17,6%) had tinnitus and 7 (6,9%) had complaint of hearing loss. 53 (52%) patients had cochlear toxicity confirmed by tone threshold audiometry and high frequency audiometry, from which 60% received a dose of 20 mg Sb5+/kg/day (p = 0.015) and 96.2% were treated with IM MA (p = 0.001). Tinnitus has greater specificity and positive predictive value than hearing loss, with a low number of false positives, but with a high false negative value.

Conclusion
Although the large number of false negatives suggests that self-report of hearing loss or tinnitus cannot be considered a good screening test for referring the patient to an audiometry, the low number of false positives suggests the need to value the patient’s complaint for referral. Otherwise, this study reinforces the importance of audiological monitoring during treatment with MA, especially in those patients with self-reporting of hearing loss or tinnitus when treated with 20 mg Sb5+/kg/day via IM.
Socioeconomic inequality in adults undertaking HIV testing over time in Ethiopia based on data from demographic and health surveys
Authors: Endalamaw Aklilu , Gilks Charles F. , Assefa Yibeltal 
Published: February 2024

Introduction
HIV testing is the entry point to HIV prevention, care and treatment and needs continuous evaluation to understand whether all social groups have accessed services equally. Addressing disparities in HIV testing between social groups results in effective and efficient response against HIV prevention. Despite these benefits, there was no previous study on inequality and determinants over time in Ethiopia. Thus, the objective of this research was to examine socioeconomic inequality in individuals undertaking HIV testing over time, allowing for the identification of persistent and emerging determinants.

Methods
Data sources for the current study were the 2011 and 2016 Ethiopian Demographic Health Surveys. The 2016 population health survey is the one that Ethiopia used to set national AIDS response strategies; there was no other recent survey with HIV/AIDS-related indicators in Ethiopia. The final sample size for the current study was 28,478 for the year 2011 and 25,542 for the year 2016. The concentration curve and Erreygers’ concentration index were used to estimate socioeconomic inequality in HIV testing. Subsequently, decomposition analysis was performed to identify persistent and emerging contributors of socioeconomic inequality. Generalized linear regression model with the logit link function was employed to estimate the marginal effect, elasticity, Erreygers’ concentration index (ECI), and absolute and percentage contributions of each covariate.

Results
The concentration curve was below the line of equality over time, revealing the pro-rich inequality in HIV testing. The inequality was observed in both 2011 (ECI = 0.200) and 2016 (ECI = 0.213). A household wealth rank had the highest percentage contribution (49.2%) for inequality in HIV testing in 2011, which increased to 61.1% in 2016. Additional markers include listening to the radio (13.4% in 2011 and 12.1% in 2016), education status (8.1% in 2011 and 6.8% in 2016), and resident (-2.0% in 2011 and 6.3% in 2016). Persistent determinants of individuals undertaking HIV testing were age 20–34 years, geographic region, education status, marital status, religion, income, media exposure (listening to the radio, reading newspaper, watching television), knowledge about HIV/AIDS, and attitudes towards people living with HIV. Age between 35 and 44 years and urban residence emerged as new associated factors in 2016.

Conclusions
The higher HIV testing coverage was among individuals with higher socioeconomic status in Ethiopia. Socioeconomic inequality amongst individuals undertaking HIV testing was diverging over time. Household wealth rank, mass media exposure, education status, and resident took the largest share in explaining the disparity in individuals undertaking HIV testing between the lower and higher income groups. Therefore, interventions to equalise HIV testing coverage should take account of these determinants.
Associations of nuptiality perceptions, financial difficulties, and socio-demographic factors with mental health status in Australian adults: Analysis of the Household, Income and Labour Dynamics in Australia (HILDA) survey
Authors: Yeboah Asiamah-Asare Bernard Kwadwo , Peprah Prince , Adu Collins , Ahinkorah Bright Opoku , Addo Isaac Yeboah 
Published: February 2024

Objective
This study examined the association of nuptial/relationship factors, financial difficulties, and socio-demographic factors with the mental health status of Australian adults.

Design
Cross-sectional quantitative study design.

Settings, participants, and interventions
Using data from the Household, Income and Labour Dynamics in Australia (HILDA) survey wave 19, 6846 adults were included in the analysis. Mental health was measured using the mental component summary (MCS) subscale of the Short-Form Health Survey SF-36. Hierarchical multiple linear regressions were used to examine the predictors of mental health status.

Results
Overall, 7.1% of the participants reported poor mental health status. Individual financial difficulty factors explained 3.2% (p<0.001) of the variance in mental health scores. In addition, financial difficulties were negatively associated with mental health status. Nuptiality and relationship factors accounted for 9.8% (p<0.001) of the variance in mental health status.

Conclusion
The study suggests negative marital or relationship perceptions and financial difficulties are significant factors accounting for poor mental health. This finding suggests the need for more policy attention toward the social determinants of poor mental health especially nuptiality or relationship perceptions which have received less policy and research attention in Australia.
Du colonial en dehors des archives coloniales ?
Authors: Lechevallier Éric , Stemmelin Margo 
Published: February 2024

Abstract
Margo Stemmelin est doctorante à l'université Paris VIII, rattachée au laboratoire Institutions et dynamiques historiques de l’économie et de la société (IDHES), sous la direction d'Emmanuelle Sibeud. Sa thèse s'intitule « Alger, capitale orientaliste ? Construction d'une capitale savante en situation coloniale (1880–1930) », et s'appuie pour une large part sur le fonds Basset, conservé au sein des archives de l'EHESS depuis 2015. Ce fonds contient la correspondance scientifique, amicale et familiale de René Basset, arabisant et berbérisant ayant dirigé l’École puis la Faculté des Lettres d'Alger de 1894 à 1924. Il est le produit d'un acteur haut placé dans la société et l'administration, et nous dit donc quelque chose de la situation coloniale. Éric Lechevallier, quant à lui, dirige le pôle « publics » du Centre des archives diplomatiques de Nantes (CADN). Il est également doctorant à Nantes université, (Centre de recherches en histoire internationale et atlantique), sous la direction de Michel Catala, où il étudie l'Algérie et ses relations extérieures à l'indépendance, ses réflexions éclairent la dispersion et la diversité des statuts des archives des institutions coloniales, suite aux indépendances. S'appuyant chacun.e sur les documents qu'ils manient au quotidien dans leur travail, ils explorent la diversité de leurs liens avec la colonisation et reviennent, dans cet entretien croisé, sur ce qui fait à leurs yeux la « colonialité » d'un fonds ou d'une archive.
Seventy Years of Marriage and Family Law in China: Achievements, Challenges and Prospects
Authors: Guo Qingmin 
Published: February 2024

Abstract
This article examines marriage and family law in China from a diachronic perspective. It discusses three issues – the principal achievements over the last 70 years; the existing challenges since the 21st century; and its prospects for the future. The Marriage Law of the People’s Republic of China passed in 1950 was the first basic law after the founding of the People’s Republic of China and opened a new chapter in the development of Chinese marriage and family law. Significant development has been achieved both in systematic structure and institutional contents after undergoing three major revisions in 1980, 2001 and 2020. Despite the achievements made, great challenges remain since the 21st century, especially the difficulties in family formation and maintenance; population aging with fewer children; application of assisted reproductive technology; and prevalence of divorce, remarriage, and cohabitation. The future improvement of marriage and family law may focus more on maintaining family stability and building family civilization.