bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Assessment Associated with Suicidal Ideation in the Pediatric Emergency Department Utility of an Adult-Verified Risk Assessment Tool
Authors: Capua Tali , Milshtein Nili Yanai , Yacobi Assaf , Sela Yarden , Mordel Inbar , Rimon Ayelet 
Published: February 2024

Abstract
Objectives
The Substance Abuse and Mental Health Services Administration and the Suicide Prevention Resource Center created a guide for suicide risk assessment in adult emergency departments (EDs). We compared the findings of that decision support tool with those of pediatric psychiatrists' evaluations for risk stratification of pediatric ED admissions due to suicidal ideation.
Methods
The medical records of all 5- to 18-year-olds who presented to a pediatric ED due to suicidal ideation between May 2017 and January 2020 were reviewed. We used the 6-item decision support tool to retrospectively calculate and define "low" and "high" risk of attempting suicide. The recorded findings of psychiatric assessments and recommendations for management were retrieved.
Results
A total of 297 cases were included. The decision support tool calculated that 93 (31%) were low risk and 204 (69%) were high risk. Eighty-eight of the 93 low-risk patients (94.6%) were discharged home with follow-up instructions by a pediatric psychiatrist, and 5 of the 205 high-risk patients (5.4%) were admitted to an inpatient psychiatric ward for further observation. The remaining 199 high-risk patients were discharged home following psychiatric assessment with instructions to refer to mental health services follow-up
Conclusion
A decision support tool shows promise to assist the pediatric emergency physician in differentiating between low-risk youngsters presenting with suicidal ideation who may be safely discharged home with an appropriate follow-up plan and high-risk youngsters who require inpatient psychiatric observation. The tool may reduce the burden resulting from the expenditure of time and resources of a psychiatric evaluation in the ED. Prospective studies with follow-up are warranted to confirm its utility.
Abnormally accumulated GM2 ganglioside contributes to skeletal deformity in Tay-Sachs disease mice
Authors: Demir Secil Akyildiz , Seyrantepe Volkan 
Published: February 2024

Abstract

Tay-Sachs Disease is a rare lysosomal storage disorder caused by mutations in the HEXA gene which is responsible for the degradation of ganglioside GM2. In addition to progressive neurodegeneration, Tay-Sachs patients display bone anomalies including kyphosis. Tay-Sachs disease mouse model (Hexa-/-Neu3-/-) shows both neuropathological and clinical abnormalities of the infantile-onset disease phenotype. In this study, we investigated the effects of GM2 accumulation on bone remodeling activity. Here, we evaluated the bone phenotype of 5-month-old Hexa-/-Neu3-/- mice with age-matched control groups using gene expression analysis, bone plasma biomarker analysis, and micro-computed tomography. We demonstrated lower plasma alkaline phosphatase activity and calcium levels along with increased tartrate-resistant acid phosphatase levels, indicating reduced bone remodeling activity in mice. Consistently, gene expression analysis confirmed osteoblast reduction and osteoclast induction in the femur of mice. Micro-computed tomography analysis also showed a reduction in trabecular bone volume, bone mineral density, number, and thickness in Hexa-/-Neu3-/-mice. In conclusion, we demonstrated that abnormal GM2 ganglioside accumulation significantly triggers skeletal abnormality in Tay-Sachs mice. We suggest that further investigation of the molecular basis of bone structure anomalies is necessary to elucidate new therapeutic targets that prevent the progression of bone symptoms and improve the life standards of Tay-Sachs patients.
Preparation and preliminary application of a monoclonal antibody against the African swine fever virus D205R protein
Authors: Lin Zhi-Zhao , Ren Hao-Jie , Zhao Yan-Yan , Zhang Biao , Shi Sai-Yan , Han Shichong , He Wen-Rui , Wan Bo , Zhang Yuhang , Zhang GaiPing 
Published: February 2024

Abstract

Background
African swine fever (ASF) is a lethal infectious disease that causes significant economic losses to the pig industry worldwide. However, few vaccines or drugs were available to prevent or control ASF to date. The D205R protein (pD205R) is a non-structural protein of the African swine fever virus (ASFV) that is abundantly expressed in virus-infected macrophages. However, the antigenic epitopes of pD205R remain unclear.
Results
The main aim of this study was to investigate the new antigenic epitope of pD205R, providing a new tool for the prevention and diagnosis of ASF. Recombinant pD205R was firstly expressed with prokaryotic system and purified with Ni affinity chromatography. Hybridoma cell fusion, clone purification, and immunological assays were then used to develop a monoclonal antibody (mAb) against pD205R. Alanine scanning indicated that S167, W173, L174, G175, P178, and D180 were important for binding to mAb 19A5, and homologous and structural analysis revealed that these residues were highly conserved across all assessed ASFV strains and located on the protein surface.
Conclusion
The results of this study are expected to provide new insights into the development of vaccines and the establishment of serological diagnostic methods for ASF.
Short-chain fatty acids propionate and butyrate control growth and differentiation linked to cellular metabolism
Authors: Nshanian Michael , Geller Benjamin , Gruber Joshua , Chleilat Faye , Camarillo Jeannie , Kelleher Neil , Zhao Yingming , Snyder Michael 
Published: February 2024

Abstract

The short-chain fatty acids (SCFA) propionate and butyrate are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. In order to better understand the function of these modifications we used ChIP-seq to map the genome-wide location of four short-chain acyl histone marks H3K18pr/bu and H4K12pr/bu in treated and untreated colorectal cancer (CRC) and normal cells, as well as in mouse intestines in vivo. We correlate these marks with open chromatin regions along with gene expression to access the function of the target regions. Our data demonstrate that propionate and butyrate act as promoters of growth, differentiation as well as ion transport. We propose a mechanism involving direct modification of specific genomic regions, resulting in increased chromatin accessibility, and in case of butyrate, opposing effects on the proliferation of normal versus CRC cells.
Enhancing the Accuracy of GNSS-IR Sea Surface Height Retrieval with a Novel Deep-learning Composite Atmospheric Delay Correction Inversion Model
Authors: Shen Yifan , Zhu Huizhong , Zheng Wei , Wang Qiang , Chen Liang , Gui Yuqiang , Wen Jianyu 
Published: February 2024

Abstract
Accurate sea surface height (SSH) is critical for marine research and is an important basis for establishing the ocean gravity field. The Global Navigation Satellite System Interferometry Reflectometry (GNSS-IR) monitors SSH changes around the station, but it includes troposphere, ionosphere and other errors. Hence, it is crucial to remove these errors for accurate GNSS-IR sea surface altimetry. This study introduces a new Deep-learning Composite atmospheric delay Correction Inversion Model (DCCIM), which integrates a long short-term memory network based on the traditional GNSS-IR algorithm and the factor-driven dataset. This approach considers the atmospheric delay for factor-driven dataset to improve the accuracy of GNSS-IR SSH inversion. The Pearson's correlation coefficient (PCC) between the DCCIM and tide gauge data is 0.92, with a maximum of 0.99 at GOM1 GNSS station. The root mean square error (RMSE) ranged from 4.35 cm (TRRG) to 7.13 cm. This strongly suggests that the DCCIM can be used to effectively monitor SSH changes. To objectively demonstrate the superiority of the DCCIM over traditional GNSS-IR, the DCCIM and GNSS-IR are used to invert SSH changes and then compared with tide gauge data. In addition, this finding also shows that the DCCIM significantly promote the SSH inversion accuracy compared with that of conventional GNSS-IR altimetry. The RMSE was 61.74% lower on average, and the PCC was 67.44% higher. This highly valuable study provides effective SSH monitoring and a coastal SSH inversion technique for high-precision ocean gravity field construction.
Enhancing the performance of earth to air heat exchanger using annular and perforated fins ; numerical and experimental study
Authors: Hummood Eman A. , Hasan Mushtaq 
Published: February 2024

Abstract
In this study, a thorough investigation was conducted on an air-to-ground heat exchanger system designed for cooling of air compression equipments in oil pipe line system south of Iraq. The research involved numerical and experimental simulations for comparing non-finned tubes with finned tubes of various shapes, such as annular fin tubes, circular perforated annular fin tubes, and square perforated annular fin tubes. The system, utilizing a 1.5-meter-long, 6-inch-diameter PVC pipe buried approximately 3.5 meters deep in the ground, demonstrated effective cooling during summer and warmth in winter in Nasiriyah, southern Iraq, where the ground temperature remains relatively constant at around 30 degrees Celsius at a depth of 3 meters throughout the year. Practical experiments conducted from July to August 2023 revealed that, despite high inlet temperatures, annularly finned tubes exhibited superior heat transfer rates and higher pressure drops in both theoretical simulations and practical experiments compared to non-finned tubes. The consistent low outlet temperatures contributed to efficient system cooling. Theoretical simulations also indicated that finned tubes, particularly those in annular shapes, outperformed non-finned tubes in terms of heat transfer rates. The annularly finned tube demonstrated the most effective cooling performance despite challenging external conditions, generating the highest pressure drop among various fin shapes and non-finned tubes. Furthermore, the system showcased energy efficiency by consuming less electrical energy, emphasizing its effectiveness in providing cooling under demanding environmental circumstances.
Application of ROI Feature Decomposition and Local Matching in Multi-Object Tracking
Authors: Yang Jinlong , Ban Yandeng , Liu Jianjun 
Published: February 2024

Abstract
For multi-object tracking (MOT), matching newly detected target features and trajectory features often involves template matching. Typically, feature embedding for multi-object tracking relies on either the mean feature within the Region of Interest (ROI) or the vector at the target's center. However, both of these feature embeddings are vulnerable to interference in scenarios involving occlusion. Additionally, one-to-many (O-T-M) style matching strategies are prone to causing the loss of trajectories and detections, as one target only represented by a single indicator. To overcome those limitations, we propose utilizing Principal Component Analysis (PCA) on the target ROI to decompose target features, expressing the identical feature of targets by collectively representing the principal component features of the ROI region, and utilizing these principal component features to form local features, the identical features are then trained through a classification task. Furthermore, in the template matching process, we introduce a local features matching algorithm for targets and trajectories. This algorithm adopts a many-to-many (M-T-M) matching style, aiming to associate every detailed part of the ROI feature. Experimental results demonstrate that the proposed local matching algorithm effectively handles complex and dynamic scenes. The approach achieves leading performance on the motchallenge benchmark, validating its effectiveness.
Zoledronic Acid-Induced Orbital Inflammatory Disease
Authors: veisi amirreza , piryaiee golbarg , tahavvori mohammadreza 
Published: February 2024

Abstract
Bisphosphonates are a group of drugs that are used to prevent the loss of bone density and treat osteoporosis and similar bone diseases. Zoledronate (zolenedronic acid) has been increasingly used because of its advantages of intravenous infusion and annual regimens. Here, we present a case of zolendronic acid-related diffuse orbital inflammation. A 67-year-old woman with a history of breast cancer and chemotherapy developed severe unilateral orbital and periorbital swelling approximately 8 hours after receiving her first zoledronate infusion. In this case, the interval between infusion and the beginning of the symptoms was too short compared with most other reported similar cases. Her signs and symptoms relapsed 4 days after discontinuation of the short course of systemic steroid therapy. Orbital inflammation improved after systemic corticosteroid therapy was restarted, but the patient did not relapse following discontinuation of the drug in a tapering manner.
An Efficient 3D Non-Linear Lifting-Line Method with Correction for Post-Stall Regime
Authors: Simonet Théo , Roncin Kostia , Faure Thierry , Daridon Loïc 
Published: February 2024

Abstract

The ongoing development of low order methods providing fast estimations of aerodynamic loading are essential for pre-dimensioning and optimization of wings and fins. The aim of this study is to present an efficient 3D Non-Linear Lifting-Line Method enhanced by an artificial viscosity correction, able to give reliable results for post-stall regime, where conventional lifting-line methods usually fail. In the present method, the lifting-line governing equation is solved by a Newton-Raphson algorithm, with an analytical Jacobian matrix. An artificial viscosity term has been added to the governing equation, in order to regularize the solution for post-stall regime. A unique parameter was defined to control the amount of artificial viscosity introduced in the governing equation. The investigations focus on the influence of the amount of artificial viscosity on the regularization of the final solution. The perturbation generated by the artificial viscosity on the governing equation is also analyzed. The method has been validated and evaluated with linear and non-linear test cases, from analytical and experimental data from the literature. It was shown that there is an optimal amount of artificial viscosity leading to a converged solution, for post-stall regime, associated with smooth circulations along the wing span, coherent 3D lift coefficients, and low deviations from the initial governing equation. When the amount of artificial viscosity increases beyond this optimal value, the solution deteriorates. The optimal value of the parameter controlling the amount of artificial viscosity has been found to be practically insensitive to the angle of attack, and to the wing discretization.
Label-Free Evanescent Imaging of Cellular Heterogeneity in Membrane Protein Binding Kinetics
Authors: Zhang Pengfei , Huang Caixin , Liu Zhaoyang , Xu Jiying , Li Liangju , Chen Yi , Zhao Ying 
Published: February 2024

Abstract
Quantifying cellular heterogeneity of membrane protein binding kinetics is challenging but important for exploring drug resistance and screening drugs. Label-free analysis methods have emerged as promising tools for in situ binding kinetics analysis, but they have not been used for high throughput single cell analysis in live cells. Here we show that this is possible with Evanescent Scattering Microscopy (ESM). The ESM permits analyzing the kinetics of ligand binding onto membrane proteins in individual fixed and live cells, and provides a throughput of ~200 cells in a single measurement with a period of ~7 minutes. The statistical analysis further shows that the dissociation rate constant dominates the heterogeneity of cell responses to ligand binding, providing evidence for a long-standing hypothesis that the drug-target residence time may play a critical role in drug treatment. In addition, the ESM reveals that under some conditions the cells have responses to drug binding at the single cell level, whereas the ensemble measurements may average out the individual differences and present false negative results. We anticipate that the new evanescent imaging method will provide a powerful tool to quantify the functions of cellular proteins, especially their cell-to-cell heterogeneity that can provide fuel for drug resistance.
Physicochemical characterization of starch/citrate- capped plasmonic nanoparticles for effective quantification of fenobucarb pesticides in fruits
Authors: Rovina Kobun , Xia Felicia Ling Wen , Mamat Hasmadi , Maftuch Maftuch , Aziz Ahmad Hazim Abdul , Suriati Luh 
Published: February 2024

Abstract
Nanoparticles have attracted considerable attention from researchers due to their notable optical properties, demonstrating a significant enhancement in UV-visible sensitivity. This investigation aimed to fabricate colorimetric films through the amalgamation of starch with silver nanoparticles (Cit-AgNPs) for fenobucarb detection in fruits. The resultant films presented a uniform surface, the thickness of which was contingent upon the quantity of Cit-AgNPs integrated. Introducing fenobucarb into the Cit-AgNPs film induced displacement of negatively charged Ag surfaces. Remarkably, metal nanoparticles endowed with specific ligands have exhibited substantial promise in the advancement of miniaturized colorimetric assays, capable of detecting a broad spectrum of molecules, thereby facilitating the identification of trace-level target analytes through discernible visible color alterations perceptible to the unaided eye. Using localized surface plasmon resonance principles and nanoparticle self-assembly aggregation, plasmonic Ag has been effectively enhanced, resulting in a transition from yellow to dark grey-brown hue. The proposed sensor methodology demonstrates a linear range spanning from 0.005 µM to 500 µM, with a limit of detection and a limit of quantification of 8.86 µM and 29.53 µM, respectively. Determining fenobucarb in grapes, pumpkins, and passion fruit has consistently exhibited high reproducibility and reliability. This study is a paradigm of a straightforward, expeditious, and economically viable approach for fenobucarb detection in food commodities, presenting a novel avenue for evaluating food safety.
Investigating the relationship between self-regulated learning and language proficiency among EFL students in Vietnam
Authors: Dong Hoang Minh , Habók Anita 
Published: February 2024

Abstract
Self-regulated learning strategies have received significant attention by researchers and become the topic of many empirical studies since they are believed to significantly influence the achievement levels in acquiring a foreign language. The current research investigated the self-regulated learning strategies most commonly employed by Vietnamese EFL students, as well as any potential correlation between these strategies and language proficiency levels. The study involved the random selection of 140 undergraduate students to participate. The participants had different levels of English proficiency and learning backgrounds. They completed a self-regulated learning (SRL) questionnaire including 50 items, which is comprised of two parts. The first part gathers participants' personal details, including age, major of study, duration of English learning, and English proficiency determined through international test outcomes, while the second part assesses the participants' utilization frequency of SRL strategies. Quantitative methods were utilized to collect data, and descriptive statistics, and correlation analysis were performed to investigate the correlation between self-regulated learning and the language proficiency of learners. Results indicated that the participants often employed a range of self-regulation strategies for language learning. The three strategies that were most frequently used by the participants were elaboration, help-seeking, and time and study environment management, while critical thinking and effort regulation were the least employed strategies. Furthermore, a notable positive association was observed between students’ self-regulated learning strategies and their language proficiency. It was clear that language proficiency and elaboration strategy correlated most significantly, while the lowest correlation existed between language proficiency and effort regulation.
Estimating the number of states of a quantum system via the Rodeo algorithm for quantum computation
Authors: Rocha Julio Cesar Siqueira , Gomes Raphael Fortes Infante , Nogueira Wallon Anderson Tadaiesky , Dias Rodrigo Alves 
Published: February 2024

Abstract

In the realm of statistical physics, the number of states in which a system can be realized with a given energy is a key concept that bridges the microscopic and macroscopic descriptions of physical systems. For quantum systems, many approaches relies on the solution of the Schr\"odinger equation. Our proposal introduces a customization of the recently developed rodeo algorithm to enables us to determine the number of states associated with all energy levels without any knowledge of the eigenstates. Quantum computers, with their innate ability to address the intricacies of quantum systems, make this approach particularly promising for the study of the thermodynamics of those systems. To illustrate the effectiveness of our approach, we apply it to compute the number of states of the 1D transverse-field Ising model and, consequently, its specific heat, proving the reliability of the method present here.
Psychometric properties of the SF-8 Health-Related Quality of Life Scale in Costa Rican
older adults
Authors: Román-Quirós Rafael , Blanco-Molina Mauricio , Pinazo-Hernandis Sacramento 
Published: February 2024

Abstract
Objective
To assess the psychometric properties of the SF-8 health-related quality of life (HRQoL) scale in older adults from Costa Rica.
Method
The sample consisted of 282 Costa Ricans aged 50 years or older, with an average age of 64 years (SD = 7.55). Data were collected between 2015–2016 in the Greater Metropolitan Area of Costa Rica.
Results
Confirmatory factor analysis revealed that the three-factor model (physical health, mental health, and general health) demonstrated a good fit (χ2 = 53.5, df = 17, p < .001; CFI = .964; RMSEA = .09 [.061–.114], SRMR = .045), along with a reliability of .87, based on Cronbach's alpha. The three-factor model showed a better fit than the traditional two-factor model did. Furthermore, significant relationships were found between HRQoL and satisfaction with present life, social support networks, and functional social support, supporting the nomological validity of SF-8 as a comprehensive measure of health perception in older Costa Ricans.
Conclusions
The three-factor model proved to be a superior solution to the traditional model. The designation of the third factor as one of general health is questioned, as it could equally be considered a social factor related to health given its importance for older individuals. The results endorse the utility of the SF-8 as a valid and reliable tool for measuring HRQoL in this population.