bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment for bone health in patients with differentiated thyroid carcinoma after postoperative thyroid-stimulating hormone suppression therapy: a new fracture risk assessment algorithm
Authors: Jia Huiran , Qu Wei , Cai Xiaoting , Li Meiye , Qian Ying , Jiang Zhaoshun , Zhang Zongjing 
Published: November 2023

PurposeThe fracture risk assessment tool (FRAX) is used to assess the 10-year risk of major site and hip fractures; however, whether this tool can be applied to patients receiving levothyroxine-based thyroid-stimulating hormone (TSH) suppressive therapy for postoperative differentiated thyroid cancer (DTC) patients is yet to be clarified.Methods and designA total of 64 patients with DTC following thyroidectomy and oral levothyroxine for TSH suppression therapy and 30 gender- and age-matched controls were collected. The fracture risk was compared between the affected groups with different TSH levels. FRAX was used to calculate the fracture risk with and without bone mineral density (BMD). The TSH level was converted to an age-weighted score to estimate the fracture risk of postoperatively differentiated thyroid cancer patients. The sensitivity, specificity, and area under the AUC curve of the traditional FRAX and the new algorithm for osteoporosis diagnosis were compared. The dual-energy X-ray bone mineral density measurement T score was used as the gold standard to diagnose osteoporosis.ResultsThere were 24 patients in the T ≥ −1–2.5 group, 23 in the −2.5 &lt; T &lt; −1 group, and 17 in the T ≤ −2.5 group. The T score of BMD in the disease group was significantly lower than that in the control group (p &lt; 0.05). The risk of MOF and hip fracture without a T score were significantly different under various TSH levels (p &lt; 0.05). The area under the curve (AUC) of FRAX without BMD for predicting major osteoporotic fractures (PMOF) and major hip fractures (PHF) was 0.694 and 0.683, respectively. The cutoff values were 2.15% and 0.25%, respectively. The AUC of FRAX with BMD for PMOF and PHF was 0.976 and 0.989, respectively, and the cutoff values were 4.15% and 1.1%, respectively. The AUC of FRAX without BMD for PMOF and PHF was 0.708 and 0.72, respectively, and the cutoff values were 5.5% and 1.55%, respectively.ConclusionsFRAX is suitable for postoperative DTC patients after TSH suppressive therapy. In the absence of BMD, TSH weighted by age can improve the specificity of FRAX in the diagnosis of osteoporosis in this population.
Immune changes in hilar tumor draining lymph nodes following node sparing neoadjuvant chemoradiotherapy of localized cN0 non-small cell lung cancer
Authors: Khalifa Jonathan , Thébault Noémie , Scarlata Clara-Maria , Norkowski Emma , Massabeau Carole , Brouchet Laurent , Peries Bataille Sophie , Casaroli Christelle , Vaz Liza , Valle Carine , Sarot Emeline , Saint-Laurent Nathalie , Martin Etienne , Pages Pierre-Benoît , Millière Alice , Mazières Julien , Cohen-Jonathan Moyal Elizabeth , Lauzéral-Vizcaïno Françoise , Ayyoub Maha 
Published: November 2023

BackgroundWhile much progress has been accomplished in the understanding of radiation-induced immune effects in tumors, little is known regarding the mechanisms involved at the tumor draining lymph node (TDLN) level. The objective of this retrospective study was to assess the immune and biological changes arising in non-involved TDLNs upon node sparing concurrent chemoradiotherapy (CRT) of non-small cell lung cancer (NSCLC) tumors.MethodsPatients with proven localized (cN0M0) NSCLC, treated by radical surgery plus lymph node dissection with (CRT+) or without (CRT-) neoadjuvant chemoradiotherapy, whereby radiotherapy was targeted on the primary tumor with no significant incidental irradiation of the non-involved TDLN station (stations XI), were identified. Bulk RNA sequencing of TDLNs was performed and data were analyzed based on differential gene expression (DGE) and gene sets enrichment.ResultsSixteen patients were included and 25 TDLNs were analyzed: 6 patients in the CRT+ group (12 samples) and 10 patients in the CRT- group (13 samples). Overall, 1001 genes were differentially expressed between the two groups (CRT+ and CRT-). Analysis with g-profiler revealed that gene sets associated with antitumor immune response, inflammatory response, hypoxia, angiogenesis, epithelial mesenchymal transition and extra-cellular matrix remodeling were enriched in the CRT+ group, whereas only gene sets associated with B cells and B-cell receptor signaling were enriched in the CRT- group. Unsupervised dimensionality reduction identified two clusters of TDLNs from CRT+ patients, of which one cluster (cluster 1) exhibited higher expression of pathways identified as enriched in the overall CRT+ group in comparison to the CRT- group. In CRT+ cluster 1, 3 out of 3 patients had pathological complete response (pCR) or major pathological response (MPR) to neoadjuvant CRT, whereas only 1 out of 3 patients in the other CRT+ cluster (cluster 2) experienced MPR and none exhibited pCR.ConclusionNeoadjuvant node sparing concurrent CRT of NSCLC patients is associated with distinct microenvironment and immunological patterns in non-involved TDLNs as compared to non-involved TDLNs from patients with non-irradiated tumors. Our data are in line with studies showing superiority of lymph node sparing irradiation of the primary tumor in the induction of antitumor immunity.
Spatial and temporal analysis of China’s healthcare resource allocation measurements based on provincial data: 2010–2021
Authors: Ren Hengna , Li Chen , Huang Yi 
Published: November 2023

BackgroundWith the development of society, industrialization, urbanization, aging, lifestyle and social transformation, environmental degradation, global warming and other factors have had a great impact on the health of the population, and there is an urgent need to take a series of practical actions to promote the improvement of national health. Among them, healthcare resource allocation plays a key role in advancing the level of national health, treatment of chronic diseases, and leisure and healthcare.MethodsThis article collected panel data on healthcare resource allocation in all provinces of China from 2010 to 2021, and comprehensively applied Analytic Hierarchy Process, comprehensive scoring method, regional difference analysis and spatial autocorrelation analysis to reveal regional differences, spatial–temporal patterns and development characteristics of healthcare resource allocation in China.ResultsIn terms of regional differences, intra-regional differences in healthcare resource allocation tend to narrow and inter-regional differences tend to widen. In terms of spatial pattern, the western provinces on the left side of the Hu Huanyong line generally have higher scores, while the central and eastern provinces on the right side of the Hu Huanyong line have lower scores, and healthcare resource allocation in the provinces on the left side of the Hu Huanyong line, such as Tibet, Xinjiang, Qinghai, Ningxia, Gansu, Inner Mongolia, Sichuan, have the spatial characteristics of HH clusters in terms of geographic location, while the southeast coastal provinces, such as Zhejiang, Fujian, Guangdong, Hainan, have the spatial characteristics of LL clusters in terms of geographic location. From the quadrant analysis, the 2010–2021 healthcare resource allocation in the first quadrant concentrates most of the provinces in the western and northeastern regions, while the third quadrant concentrates most of the provinces in the eastern region.ConclusionThe allocation of healthcare resources in China’s four major zones has undergone a process of change from “unbalanced quantity to relatively balanced quantity,” but high-quality healthcare resources are highly concentrated in the eastern part of the country, and the problem of contradiction between people and doctors is prominent. It is recommended that Internet plus healthcare technology be used to reshape the regional allocation of high-quality healthcare resources.
Implementasi Hidden Text dengan Algoritma Blowfish dan Kompresi Huffman dalam Security Dokumen
Authors: Muryanah Siti , Rahmawati Diah 
Published: November 2023

Perkembangan teknologi memberikan dampak positif dan negatif bagi penggunanya. Informasi dengan mudah dan cepat diakses oleh siapa saja, kapan saja dan dimana saja. Untuk menjaga keamanannya diperlukan suatu usaha mengamankan informasi dari pihak yang tidak berwenang. Kriptografi dan steganografi sebagai salah satu cara untuk menjaga keamanan informasi tersebut. Informasi yang kita miliki (plaint text) akan diubah menjadi suatu informasi acak atau sulit dimengerti (chiper text), biasa disebut dengan enkripsi. Selanjutnya informasi acak tersebut akan disembunyikan atau disisipkan ke dalam citra digital (encode) sehingga tidak akan membuat orang lain curiga bahwa dalam citra digital tersebut terdapat suatu informasi yang sedang disembunyikan. Citra digital yang telah disisipi suatu informasi rahasia (stego image), secara kasat mata manusia tidak ada perbedaannya baik sebelum atau sesudah disisipi informasi rahasia. Penelitian ini berhasil mengamankan informasi dalam bentuk dokumen dengan format pdf, xlsx, docx, pptx dan txt mengunakan kriptografi Blowfish dan Steganografi LSB. Ukuran dokumen hasil proses enkripsi menjadi lebih kecil dengan proses kompresi Huffman dengan nilai rata-rata 57% dari dokumen aslinya. Pengujian mengunakan 3 file dan 3 citra yang berbeda dalam masing-masing format file yaitu pdf, xlsx, docx, pptx dan txt. Pengujian terhadap stego image menghasilkan kualitas tinggi dengan nilai MSE 0,092 dan PSNR 57,12 dB.
TCTO Analisis Percepatan Waktu Pelaksanaan Proyek Kontruksi Dengan Jam Kerja Lembur Menggunakan Metode Time Cost Trade Off (TCTO) Proyek Hotel Shafira Surabaya
Authors: Susanto Irvan Dwi 
Published: November 2023

Ada banyak cara yang mungkin bisa untuk menangani terlambatnya pada durasi proyek menggunakan cara menambah pada pekerja proyek, menambah waktu lembur pekerjaan, menambah shift kerja, ataupun menggunakan alat kerja bantu agar lebih efisien. Hal yang bisa menangani untuk permasalahan terlambatnya proyek tersebut ialah durasi dalam menangani proyek dan biaya-biaya pekerja pada proyek dan pekerjaan lainnya punya hubungan yang erat pada pelaksanaan kerja. Pelaksanaan proyek Hotel Shafira Surabaya dengan biaya kontrak sebesar Rp 75.565.747.573 ini perlu di lakukan percepatan untuk waktu akan sangat perlu dilakukan, mungkin mendapatkan keterlambatan saat pengerjaan pada lapangan. Dalam penelitian ini menggunakan metode yang digunakan alternasi waktu dengan biaya (time cost trade off). Metode tersebut dengan tujuan mempercepat durasi pekerjaan di proyek dan mengkaji pengaruh durasi dipersingkat dengan penambahan alokasi biaya. Dari hasil penelitian, dapat di ketahui telah direncanakan dengan waktu durasi optimal 448 hari atau 61 minggu di bandingkan waktu normal berdurasi 455 hari atau 63 minggu menggunakan metode jam lembur selama maksimal 3 jam/hari, proyek tersebut dapat menghemat waktu sebanyak 7 hari. untuk efisiensi biaya proyek dengan biaya kompresi sebanyak Rp 9.047.960.280.
Small Dual-Band 3D Beamforming MIMO Antenna
Authors: Zandamela Abel , Marchetti Nicola , Narbudowicz Adam 
Published: November 2023

<p>This work proposes a small dual-band (2.4 GHz and 4.89 GHz bands) 3D beamforming Multiple-Input Multiple-Output (MIMO) antenna for emerging size-constrained Internet of Things (IoT) applications. The performance is realized via digital beamforming in a structure sized only 51.5 mm in diameter (smaller than half wavelength at 2.4 GHz). At the 2.4 GHz band, the antenna realizes an isolation > 30 dB, and the Envelope Correlation Coefficient (ECC) is < 0.0003), with a bi-directional beamforming capability in the azimuth plane and unidirectional beamforming across the elevation plane. At the 4.89 GHz band, the isolation is > 19 dB, and the ECC< 0.0047, while unidirectional beamforming is achieved in both the azimuth and elevation planes. </p>
Passive Intermodulation in Metal-to-Metal Contacts Caused by Tunneling Current
Authors: Dayan Amir , Huang Yi , Gustafsson Mattias , Olsson Torbjörn , Schuchinsky Alexander G. 
Published: November 2023

<p>Passive intermodulation (PIM) by metal contacts limits the bandwidth and capacity of radio links used in mobile and satellite communications. In this work, we investigate the effect of nonlinearities of metal-to-metal contacts and their effects on PIM generation. An analytical expression is obtained for the tunneling current density which has an error of ~1.6% in the case of a very thin insulator and low voltages in MIM (Metal-InsulatorMetal) junctions. The presented analytical model of the contact surfaces with the fractal geometry is applied to simulate PIM products of third-order (PIM3) and fifth-order (PIM5) versus the contact resistance and applied pressure. The simulation results are validated experimentally by an open-ended rectangular coaxial structure with a slotted enclosure. The measurement results demonstrate that the presented model predicts the PIM with a mean error of about 4.8 dB when the contact pressure varies from 0.5 MPa to 1.7 MPa.<br>
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Subjective Technologies An Exoskeleton for the Mind
Authors: Tomas Borda Pablo 
Published: November 2023

<p>Embark on a transformative journey into the realm of Subjective Technologies ( Zero-Input technology) ! Join our research initiative to explore groundbreaking concepts in user-centric technology, transhumanism, and the fusion of human and machine intelligence. Dive into the future of computational affinity, cognitive amplification, and Subjective Thermo-Currency that renders the concept of money and currencies conceptually obsolete. Contribute to shaping a new era of human-computer interaction that maximizes efficiency, freedom, and potential. </p>
EFEKTIVITAS VAKSIN INAKTIF Aeromonas salmonicida Terhadap Total Leukosit dan Aktifitas Fagositosis PADA IKAN KOI (Cyprinus carpio)
Authors: Ciptaning Weargo Jati  
Published: November 2023

Aeromonas salmonicida, merupakan bakteri penyebab ikan menderita pendarahan, lesi otot, radang usus, pembesaran limpa dan menyebabkan kematian pada populasi ikan mas. Penyakit ini sangat merugikan dalam budidaya ikan karena serangannya yang cepat dan dapat mematikan hewan budidaya dan menurunkan tingkat produksi, sehingga ikan yang terserang bakteri cukup parah harus segera dimusnahkan. Berdasarkan hal tersebut diperlukan pendekatan pencegahan yang lebih alami untuk penanggulangan penyakit yang disebabkan oleh bakteri A. salmonicida, salah satunya adalah dengan penggunaan vaksin. Penelitian ini menggunakan variabel bebas berupa perlakuan pemberian vaksin inaktif A. salmonicida dengan dosis A: 104sel/ml; B: 106sel/ml; C: 108sel/ml; D: 1010sel/ml dengan tiga kali ulangan, serta menggunakan dua kontrol pembanding yaitu kontrol negatif dan kontrol positif. Dengan parameter uji viabilitas, Total Leukosit, Aktivitas Fagositosis, gejala klinis, dan kualitas air. Pengujian titer antibodi, gejala klinis, RPS (Relative Percent Survival) dan kualitas air dilakukan setelah 1-14 hari dari uji tantang dan pemberian vaksin 1 dan 2 (booster). Hasil penelitian ini menujukan peningkatan pada perlakuan C (108) berpengaruh dpaling tinggi dalam mencegah infeksi bakteri patogen A.salmonicida ditandai dengan peningkatan total leukosit sebelum dan sesudah infeksi sebesar 55,83 dan 59,43 sel/ml. Nilai aktivitas fagositosis sebesar 34,09 dam 31,88, dan pada gejala klinis ikan mengalami penyembuhan setelah hari ke 8 - 14 setelah infeksi.
Antihypertensive therapy and medication adherence in patients with uncontrolled arterial hypertension
Authors: Solntseva T. D. , Sivakova O. A. , Aksenova A. V. , Chazova I. E. 
Published: November 2023

Aim. To evaluate the antihypertensive therapy and adherence to treatment in patients with uncontrolled arterial hypertension.Materials and Мethods. The study included 297 patients hospitalized at the E.I. Chazov National Medical Research Center of Cardiology over the period from September 2019 to March 2022. Patients were spread into two groups depending on the increase in the frequency of BP: group 1 (n=149) – increase in BP above 140/90 mm Hg 1 or more per week while taking antihypertensive therapy with clinical manifestations, and group 2 (n=148) – increase in blood pressure more than 140/90 mm Hg less than 1 per week while taking antihypertensive therapy clinical manifestations. Antihypertensive therapy and medication adherence were assessed at hospital discharge and after 12 months.Results. Initially, the number of antihypertensive drugs was greater in patients with group 1 versus the patients with group 2 (p<0,001). The frequency of taking antihypertensive therapy initially and after 12 months was greater in group 1 (p<0,001). After 12 months, the number of antihypertensive drugs decreased in the group 1, and remained the same in group 2. When comparing the different classes of antihypertensive drugs, all classes, except angiotensin-converting enzyme inhibitors were most frequently prescribed in group 1 (p<0,05). After 12 months, a lower level of adherence was observed in group 1 patients compared to group 2 (6 [5-8] points vs. 8 [6-9] points) (p<0,001), as evidenced in the reduced intake of different classes of antihypertensive therapy.Conclusion. Uncontrolled arterial hypertension is a release of hypertension associated with more antihypertensive medications to be prescribed and adherence to be monitored more closely.
Élections et religions aux États-Unis
Authors: Bouaziz Margaux 
Published: November 2023

Aux États-Unis, l’enchevêtrement des relations entre religions et État(s) est bien plus important qu’en France. La Cour suprême joue à cet égard un rôle actif ; ces dernières années, elle s’est imposée comme une véritable médiatrice qui offre une protection asymétrique à la liberté religieuse : d’une part, une assez grande liberté pour les pratiques et l’intervention des groupes religieux majoritaires dans la vie politique et électorale et, d’autre part, une protection beaucoup plus marginale, voire inexistante pour les groupes minoritaires.
A pandemia de COVID-19 como temática curricular
Authors: Santos Luiza Souza dos , Valdanha Neto Diógenes 
Published: November 2023

Realizou-se um estudo qualitativo em uma rede municipal de ensino para compreender como a pandemia de COVID-19 foi abordada no currículo das séries finais do Ensino Fundamental no ano de 2020. A análise de conteúdo, de um total de 28329 atividades não presenciais, revelou que apenas 2,44% delas dialogavam com a pandemia. Constatou-se que 91% dessas atividades foram desenvolvidas sob a perspectiva da convivência com o risco de desastre, enquanto 1,5% delas nutriam uma atitude de questionamento. A literatura da educação CTS permitiu reconhecer que predominaram abordagens da promoção de “percepções” sobre a pandemia, também evidenciando certo esvaziamento das intencionalidades de “questionamentos” sobre interrelações CTS. São apontados caminhos para uma abordagem sociocientífica dessa temática nos currículos de ciências e biologia.
Abordagem de questões sociocientíficas no ensino de Biologia como mecanismo de fortalecimento do protagonismo juvenil
Authors: Moreira Maria Daiane Lopes , Freitas Herikson Araújo de 
Published: November 2023

O Protagonismo Juvenil é entendido como a capacidade dos adolescentes em participarem, de forma ativa, de atividades ou projetos de caráter público, exercendo papel transformador na sociedade. Esta pesquisa objetivou analisar a influência da abordagem de temáticas sociocientíficas, no ensino de biologia, como mecanismo de fortalecimento do protagonismo juvenil. Na coleta de dados, foram realizadas entrevistas com professores de biologia e grupo focal com estudantes do ensino médio. A organização dos dados foi feita por meio da análise das falas dos alunos, e das entrevistas aplicadas com os professores. Questões ambientais e sociais foram selecionadas e discutidas no grupo focal. Notou-se que a abordagem de aspectos sociocientíficos, nas aulas de biologia, pode desenvolver o protagonismo em estudantes da educação básica.
THE ANGLO-SCOTTISH BALLAD IN THE LIGHT OF CHANGING TRANSLATION PARADIGMS: TWO CENTURIES OF TRANSLATION
Authors:   Moscow State Pedagogical University, Prokonichev Georgy I. 
Published: November 2023

Translation of a poetic text has always attracted the eye of translators and poets who wanted to present the best works of foreign cultures to their compatriots. Due to that the folklore text, which reflects the distinctive features of a different culture, its history and beliefs, long ago became a special object of attention. At different stages of the development of translators’ art, there were different approaches to the interpretation of a literary text. In some eras, the translation was word for word, during other periods it was considered correct to improve the original text. Some linguists believed that literary text was untranslatable. However, in the 20th century, translation finally evolved into a science and the foundations of a systematic approach to translation were developed. The history of ballad translations in Russia goes back two centuries. Various poets worked with these texts and their approaches were often different. In some cases, translators transformed realities which they met int elements of their own culture, changed the rhythmic and organizational structure of the text, and even removed a few couplets. This approach is characteristic of the entire 19th century. Then the paradigm changes: other specialists try to preserve the original sound of the ballads, the archaic language and the syntax characteristic of ballads. Poetry translators of the 20th century set and gradually reach these goals, although some of them still translate within the framework of the approach of the period of classicism and make their own improvements to the text. The last stage is the latest translations. The disappearance of strict censorship gives the translator the opportunity to translate folk poetry using folk, colloquial, sometimes obscene words, although the appropriateness of their use should be carefully weighed in each case. Our investigation allows us to conclude that the development of approaches to ballad translation follows the traditional periodization of paradigms and yet some problems of poetic translation are still open.