bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Rasio NPL, LDR, NIM, BOPO, dan CAR Terhadap Profitabilitas Bank BUMN di Indonesia
Authors: Yulianah  , Seno Aji Tony 
Published: November 2023

Abstract: This study intends to examine the effect of the ratio of NPL, LDR, NIM, BOPO and CAR on Profitability (ROA) in Indonesian State-Owned Banks. The sample taken in this study is a saturated sample, that is, all of the population of these banks are sampled, namely Bank Mandiri, Bank Rakyat Indonesia, Bank Tabungan Negara, and Bank Negara Indonesia with a period of 2016-2020 quarters I to IV. The analysis technique used is panel data regression using Eviews 10 software. The results state that simultaneously NPL, LDR, NIM, BOPO, and CAR have an effect on ROA with an effect of 99.2%. While partially the NPL and NIM variables affect ROA in a positive direction, the BOPO variable affects ROA in a negative direction, the LDR and CAR variables do not affect ROA at state-owned banks in Indonesia.
Keywords: NPL, LDR, NIM, BOPO, CAR, ROA
Faktor-Faktor Yang Mempengaruhi Pemilihan Pemakaian Metode Periodik Pada UD. Pusaka Bakti
Authors: Arafah Santi 
Published: November 2023

UD. Pusaka Bakti merupakan usaha dagang yang berdiri sejak tahun 1972 dengan mengembangkan usahanya dari sabuk kelapa dan menghasilkan coco peat, keset kaki, sapu, brush, dan matras. UD. Pusaka Bakti mengalami kesulitan dalam pencatatan barang sehingga menerapkan metode periodik. Penelitian ini bertujuan untuk menganalisis seberapa besar pengaruh waktu, sistematika penyusunan anggaran dan kestabilan harga terhadap pemilihan pemakaian metode periodik di UD. Pusaka Bakti. Sampel yang digunakan dalam penelitian ini 50 responden dengan menggunakan teknik analisis regresi linier berganda. Hasil dari penelitian ini secara simultan variabel waktu, sistematika penyusunan dan kestabilan harga berpengaruh terhadap pemilihan pemakaian metode periodik dimana, terlihat dari bahwa sig adalah 0,000 < 0,05 atau F hitung > F tabel yaitu 99,166 > 2,807. Sedangkan secara parsial waktu dan sistematika penyusunan anggaran berpengaruh secara positif terhadap pemilihan pemakaian metode periodik, namun variabel kestabilan harga tidak mempengaruhi pemilihan pemakaian metode periodik
Penghayatan Nilai Ajaran Samin dalam Membentuk Sikap Enterpreneurship pada Masyarakat Samin Klopodhuwur Kabupaten Blora
Authors: Kusuma Aryanti Muhtar , Anjani Reza Kurnia 
Published: November 2023

The Samin Klopodhuwur community is a group of people who still choose a naturalist lifestyle in their lives, but have relevant and strong values and norms. The teachings inherited from the ancestors of the Samin people are still maintained and preserved. The purpose of this study is first to find out what Saminism values shape entrepreneurial attitudes. Second is to find out to what extent Samin's entrepreneurial value contributes to the economic welfare of the Samin community. This research is field research using the qualitative method with the phenomenological approach. Researchers conducted research on the Samin tribe in Klopodhuwur, Blora Regency, regarding the appreciation of Samin's teaching values, its role in shaping entrepreneurial attitudes. The data collection techniques used observation, interviews, and documentation for each informant who was the subject of the study.
The results of this study indicate that, First Values of Saminism of the people of Kopodhuwur Village, Blora Regency, which are still firmly held in an entrepreneurial attitude, honest, independent, disciplined, friendly and keep promises. Second, by establishing the basic values of Samin's teachings such as being honest, independent, disciplined, friendly and keeping promises applied to entrepreneurial values, the Klopodhuwur village community already has performances in entrepreneurship to improve the economic welfare of the Samin people
Exploring the impact of oral bacteria remnants on stem cells from the Apical papilla: mineralization potential and inflammatory response
Authors: Zymovets Valeriia , Rakhimova Olena , Wadelius Philip , Schmidt Alexej , Brundin Malin , Kelk Peyman , Landström Maréne , Vestman Nelly Romani 
Published: November 2023

IntroductionBacterial persistence is considered one of the main causal factors for regenerative endodontic treatment (RET) failure in immature permanent teeth. This interference is claimed to be caused by the interaction of bacteria that reside in the root canal with the stem cells that are one of the essentials for RET. The aim of the study was to investigate whether prolonged exposure of stem cells from the apical papilla (SCAP) to bacterial remnants of Fusobacterium nucleatum, Actinomyces gerensceriae, Slackia exigua, Enterococcus faecalis, Peptostreptococcaceae yurii, commonly found in infected traumatized root canals, and the probiotic bacteria Lactobacillus gasseri and Limosilactobacillus reuteri, can alter SCAP’s inflammatory response and mineralization potential.MethodsTo assess the effect of bacterial remnants on SCAP, we used UV-C–inactivated bacteria (as cell wall-associated virulence factors) and bacterial DNA. Histochemical staining using Osteoimage Mineralization Assay and Alizarin Red analysis was performed to study SCAP mineralization, while inflammatory and osteo/odontogenic-related responses of SCAPs were assessed with Multiplex ELISA.ResultsWe showed that mineralization promotion was greater with UV C–inactivated bacteria compared to bacterial DNA. Immunofluorescence analysis detected that the early mineralization marker alkaline phosphatase (ALP) was increased by the level of E. coli lipopolysaccharide (LPS) positive control in the case of UV-C–inactivated bacteria; meanwhile, DNA treatment decreased the level of ALP compared to the positive control. SCAP’s secretome assessed with Multiplex ELISA showed the upregulation of pro-inflammatory factors IL-6, IL-8, GM-CSF, IL-1b, neurotrophic factor BDNF, and angiogenic factor VEGF, induced by UV-C–killed bacteria.DiscussionThe results suggest that long term stimulation (for 21 days) of SCAP with UV-C–inactivated bacteria stimulate their mineralization and inflammatory response, while DNA influence has no such effect, which opens up new ideas about the nature of RET failure.
Comparative genomics analysis of Stenotrophomonas maltophilia strains from a community
Authors: Li Yini , Liu Xin , Chen Lingzhi , Shen Xiao , Wang Haihong , Guo Ruiyu , Li Xiang , Yu Zehui , Zhang Xiaoli , Zhou Yingshun , Fu Li 
Published: November 2023

BackgroundStenotrophomonas maltophilia is a multidrug-resistant (MDR) opportunistic pathogen with high resistance to most clinically used antimicrobials. The dissemination of MDR S. maltophilia and difficult treatment of its infection in clinical settings are global issues.MethodsTo provide more genetic information on S. maltophilia and find a better treatment strategy, we isolated five S. maltophilia, SMYN41–SMYN45, from a Chinese community that were subjected to antibiotic susceptibility testing, biofilm formation assay, and whole-genome sequencing. Whole-genome sequences were compared with other thirty-seven S. maltophilia sequences.ResultsThe five S. maltophilia strains had similar antibiotic resistance profiles and were resistant to β-lactams, aminoglycosides, and macrolides. They showed similar antimicrobial resistance (AMR) genes, including various efflux pumps, β-lactamase resistance genes (blaL1/2), aminoglycoside resistance genes [aac(6’), aph(3’/6)], and macrolide-resistant gene (MacB). Genome sequencing analysis revealed that SMYN41-SMYN45 belonged to sequence type 925 (ST925), ST926, ST926, ST31, and ST928, respectively, and three new STs were identified (ST925, ST926, and ST928).ConclusionThis study provides genetic information by comparing genome sequences of several S. maltophilia isolates from a community of various origins, with the aim of optimizing empirical antibiotic medication and contributing to worldwide efforts to tackle antibiotic resistance.
Variation in VEGFA and risk of cardiovascular disease in the UK Biobank
Authors: Chen Hongyin , Lv Xingyu , Yang Jinzhao , Chen Zhaojun , Qiao Wanning , Zhou Tao , Zhang Yang 
Published: November 2023

BackgroundCardiovascular disease (CVD) is an escalating global health crisis, contributing significantly to worldwide mortality and morbidity. Dyslipidemia stands as a critical risk factor for CVD. Vascular endothelial growth factor A (VEGFA) is pivotal in angiogenesis and represents a clinical target for CVD intervention. However, the impact of genetic modulation of VEGFA on lipid levels and the subsequent risk of cardiovascular events remains unclear.MethodsWe used LDpred2 to calculate genetic scores for lipid levels based on VEGFA variation, serving as instrumental variables to simulate the effect of VEGFA inhibitors. We then assessed the associations between genetic risk for lipid levels and CVD risk by conducting One-sample Mendelian randomization.ResultsOur results indicated that low-density lipoprotein cholesterol [LDL-C; odds ratio (OR) = 1.09, 95% CI: 1.06–1.11], remnant cholesterol (RC; OR = 1.24, 95% CI: 1.13–1.36), and triglycerides (TG; OR = 1.14, 95% CI: 1.07–1.22) were positively associated with the incidence of CVD. In contrast, high-density lipoprotein cholesterol (HDL-C) was inversely associated with the incidence of CVD (OR = 0.80, 95% CI: 0.76–0.86). When considering the genetic score for LDL-C constructed based on VEGFA, the group with a high genetic score demonstrated an elevated CVD risk (OR = 1.11, 95% CI: 1.04–1.19) compared to those with a low genetic score. Notably, One-sample Mendelian randomization results provided evidence of a causal relationship between LDL-C and CVD (p = 8.4×10−3) when using genetic variation in VEGFA as an instrumental variable.ConclusionsGenetic variation mimicking the effect of VEGFA inhibition, which lowers LDL-C levels, was causally associated with a reduced risk of cardiovascular events. These findings offer insight into the potential therapeutic relevance of modulating VEGFA-mediated lipid changes in the prevention and management of CVD.
FLAP: a framework for linking free-text addresses to the Ordnance Survey Unique Property Reference Number database
Authors: Zhang Huayu , Casey Arlene , Guellil Imane , Suárez-Paniagua Víctor , MacRae Clare , Marwick Charis , Wu Honghan , Guthrie Bruce , Alex Beatrice 
Published: November 2023

IntroductionLinking free-text addresses to unique identifiers in a structural address database [the Ordnance Survey unique property reference number (UPRN) in the United Kingdom (UK)] is a necessary step for downstream geospatial analysis in many digital health systems, e.g., for identification of care home residents, understanding housing transitions in later life, and informing decision making on geographical health and social care resource distribution. However, there is a lack of open-source tools for this task with performance validated in a test data set.MethodsIn this article, we propose a generalisable solution (A Framework for Linking free-text Addresses to Ordnance Survey UPRN database, FLAP) based on a machine learning–based matching classifier coupled with a fuzzy aligning algorithm for feature generation with better performance than existing tools. The framework is implemented in Python as an Open Source tool (available at Link). We tested the framework in a real-world scenario of linking individual’s (n=771,588) addresses recorded as free text in the Community Health Index (CHI) of National Health Service (NHS) Tayside and NHS Fife to the Unique Property Reference Number database (UPRN DB).ResultsWe achieved an adjusted matching accuracy of 0.992 in a test data set randomly sampled (n=3,876) from NHS Tayside and NHS Fife CHI addresses. FLAP showed robustness against input variations including typographical errors, alternative formats, and partially incorrect information. It has also improved usability compared to existing solutions allowing the use of a customised threshold of matching confidence and selection of top n candidate records. The use of machine learning also provides better adaptability of the tool to new data and enables continuous improvement.DiscussionIn conclusion, we have developed a framework, FLAP, for linking free-text UK addresses to the UPRN DB with good performance and usability in a real-world task.
Global research trends of diabetes remission: a bibliometric study
Authors: Yang Xue , He Zhiwei , Chen Qilin , Chen Yu , Chen Guofang , Liu Chao 
Published: November 2023

BackgroundResearch on diabetes remission has garnered prominence in recent years. However, to date, no pertinent bibliometric study has been published. This study sought to elucidate the current landscape and pinpoint potential new research directions through a bibliometric analysis of diabetes remission.MethodsWe perused relevant articles on diabetes remission from January 1, 2000, to April 16, 2023, in the Web of Science. We utilized CiteSpace software and VOSviewer software to construct knowledge maps and undertake analysis of countries, institutional affiliations, author contributions, journals, and keywords. This analysis facilitated the identification of current research foci and forecasting future trends.ResultsA total of 970 English articles were procured, and the annual publication volume manifested a steady growth trend. Most of the articles originated from America (n=342, 35.26%), succeeded by China and England. Pertaining to institutions, the University of Newcastle in England proliferated the most articles (n=36, 3.71%). Taylor R authored the most articles (n=35, 3.61%), and his articles were also the most co-cited (n=1756 times). Obesity Surgery dominated in terms of published articles (n=81, 8.35%). “Bariatric surgery” was the most prevalently used keyword. The keyword-clustering map revealed that the research predominantly centered on diabetes remission, type 1 diabetes, bariatric surgery, and lifestyle interventions. The keyword emergence and keyword time-zone maps depicted hotspots and shifts in the domain of diabetes remission. Initially, the hotspots were primarily fundamental experiments probing the feasibilities and mechanisms of diabetes remission, such as transplantation. Over the course, the research trajectory transitioned from basic to clinical concerning diabetes remission through bariatric surgery, lifestyle interventions, and alternative strategies.ConclusionOver the preceding 20 years, the domain of diabetes remission has flourished globally. Bariatric surgery and lifestyle interventions bestow unique advantages for diabetes remission. Via the maps, the developmental milieu, research foci, and avant-garde trends in this domain are cogently portrayed, offering guidance for scholars.
Research progress on the mechanism of glycolysis in ovarian cancer
Authors: Li Chan , Liu Fang-Yuan , Shen Ying , Tian Yuan , Han Feng-Juan 
Published: November 2023

Glycolysis is the preferred energy metabolism pathway in cancer cells even when the oxygen content is sufficient. Through glycolysis, cancer cells convert glucose into pyruvic acid and then lactate to rapidly produce energy and promote cancer progression. Changes in glycolysis activity play a crucial role in the biosynthesis and energy requirements of cancer cells needed to maintain growth and metastasis. This review focuses on ovarian cancer and the significance of key rate-limiting enzymes (hexokinase, phosphofructokinase, and pyruvate kinase, related signaling pathways (PI3K-AKT, Wnt, MAPK, AMPK), transcription regulators (HIF-1a), and non-coding RNA in the glycolytic pathway. Understanding the relationship between glycolysis and these different mechanisms may provide new opportunities for the future treatment of ovarian cancer.
Comparison of two RT-qPCR methods targeting BK polyomavirus microRNAs in kidney transplant recipients
Authors: Zoubir Kenza , Descamps Véronique , Aubry Aurélien , Helle Francois , Francois Catherine , Castelain Sandrine , Brochot Etienne , Demey Baptiste 
Published: November 2023

BackgroundBK polyomavirus replication leads to progressive tubulointerstitial nephritis and ureteral stenosis, with a considerable risk of subsequent graft failure in kidney transplant recipients. Since specific antiviral therapies are lacking, new tools are required to enhance the biological monitoring of the infection. Viral microRNAs are promising new biomarkers, but the performance of RT-qPCR methods limits the clinical application and the validation of a standard method for quantification.MethodsWe compared TaqMan microRNA Assays and TaqMan Advanced miRNA Assays for bkv-miR-B1-3p and bkv-miR-B1-5p quantification in synthetic microRNA templates and in 44 urine samples belonging to 14 consecutive kidney transplant recipients with BK polyomavirus replication from Amiens University Medical Center in a 1-year span.ResultsCycle threshold values were constantly higher with TaqMan Advanced MicroRNA Assays. TaqMan microRNA Assays showed better performance in predicting the good prognosis of BK polyomavirus nephropathy.ConclusionOverall, TaqMan MicroRNA Assays appeared to be a more sensitive and accurate RT-qPCR method than TaqMan Advanced MicroRNA Assays to quantify bkv-miR-B1-3p and bkv-miR-B1-5p BKPyV miRNAs in patients’ urine samples.
Case Report: A rare case of multicentric angiosarcomas of bone mimicking multiple myeloma on 18F-FDG PET/CT
Authors: Huang Wenpeng , Xiao Xiaoyan , Zhang Yongbai , Peng Yushuo , Song Lele , Li Liming , Gao Jianbo , Kang Lei 
Published: November 2023

BackgroundAngiosarcoma, a rare endothelial-origin tumor, can develop throughout the body, with the head and neck skin being the most commonly affected areas. It can also originate in other sites such as the breast, iliac artery, and visceral organs including the liver, spleen, and kidneys. Angiosarcoma of the bone is remarkably rare, presenting as either unifocal or multifocal bone lesions and often leading to a grim prognosis. Diagnosing bone angiosarcoma poses a significant challenge. 18F-FDG PET/CT serves as a reliable and indispensable imaging modality for evaluating distant metastases and clinically staging angiosarcomas.Case reportA 57-year-old woman presented with a 10-day history of dizziness and headaches. Cranial CT scan revealed bone destruction of the parietal bone, accompanied by soft tissue lesions, protruding into the epidural space. MRI examination demonstrated lesions with slightly elevated signal intensity on T2FLAIR, showing moderate enhancement. Furthermore, multiple foci were observed within the T12, L1-5, and S1-2 vertebrae, as well as in the bilateral iliac bones. For staging, 18F-FDG PET/CT was performed. The MIP PET showed multifocal FDG-avid lesions in the sternum, bilateral clavicles, bilateral scapulae, multiple ribs, and pelvic bones. Heterogeneous FDG uptake was observed in multiple bone lesions, including intracranial (SUVmax = 11.3), right transverse process of the T10 vertebra (SUVmax = 5.8), ilium (SUVmax = 3.3), and pubis (SUVmax = 4.7). The patient underwent surgical resection of the cranial lesion. The pathological diagnosis was made with a highly differentiated angiosarcoma.ConclusionAngiosarcoma of bone on FDG PET/CT scans is characterized by abnormal FDG uptake along with osteolytic destruction. This case highlights that angiosarcoma of bone can manifest as multicentric FDG uptake, resembling the pattern seen in multiple myeloma. FDG PET/CT can be a useful tool for staging this rare malignant tumor, offering the potential to guide biopsy procedures toward the most metabolically active site. And it should be considered in the differential diagnosis of multiple osteolytic lesions, including metastatic carcinoma, multiple myeloma, and lymphoma of bone.
Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes
Authors: Luinenburg Mark J. , Scheper Mirte , Sørensen Frederik N. F. , Anink Jasper J. , Van Hecke Wim , Korshunova Irina , Jansen Floor E. , Riney Kate , van Eijsden Pieter , Gosselaar Peter , Mills James D. , Kalf Rozemarijn S. , Zimmer Till S. , Broekaart Diede W. M. , Khodosevich Konstantin , Aronica Eleonora , Mühlebner Angelika 
Published: November 2023

IntroductionConstitutive activation of the mTOR pathway, as observed in Tuberous Sclerosis Complex (TSC), leads to glial dysfunction and subsequent epileptogenesis. Although astrocytes are considered important mediators for synaptic clearance and phagocytosis, little is known on how astrocytes contribute to the epileptogenic network.MethodsWe employed singlenuclei RNA sequencing and a hybrid fetal calf serum (FCS)/FCS-free cell culture model to explore the capacity of TSC-derived astrocytes to maintain glutamate homeostasis and clear debris in their environment.ResultsWe found that TSC astrocytes show reduced maturity on RNA and protein level as well as the inability to clear excess glutamate through the loss of both enzymes and transporters complementary to a reduction of phagocytic capabilities.DiscussionOur study provides evidence of mechanistic alterations in TSC astrocytes, underscoring the significant impairment of their supportive functions. These insights enhance our understanding of TSC pathophysiology and hold potential implications for future therapeutic interventions.
No neuroprotective effect of therapeutic hypothermia following lipopolysaccharide-sensitized hypoxia-ischemia: a newborn piglet study
Authors: Andersen Mads , Andersen Hannah Brogård , Andelius Ted Carl Kejlberg , Hansen Lærke Hjøllund , Pinnerup Regitze , Bjerre Mette , Ringgaard Steffen , Schwendimann Leslie , Gressens Pierre , Kyng Kasper Jacobsen , Henriksen Tine Brink 
Published: November 2023

IntroductionTherapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflammation before a hypoxic-ischemic insult. We aimed to compare newborn piglets with lipopolysaccharide-sensitized hypoxia-ischemia treated with and without therapeutic hypothermia with regards to measures of neuroprotection.MethodsA total of 32 male and female piglets were included in this randomized experimental study. Lipopolysaccharides from Escherichia coli were infused intravenously before initiation of a standardized global hypoxic-ischemic insult. The piglets were then randomized to either normothermia or therapeutic hypothermia. After 14 h, the piglets were evaluated. Our primary outcome was brain lactate/N-acetylaspartate ratio assessed by magnetic resonance spectroscopy. Secondary outcomes included measures of magnetic resonance imaging, amplitude-integrated electroencephalography, immunohistochemistry, and concentration of blood cells and cytokines.ResultsPiglets treated with and without therapeutic hypothermia were subjected to comparable global hypoxic-ischemic insults. We found no difference between the two groups with regards to measures of magnetic resonance spectroscopy and imaging, amplitude-integrated electroencephalography, immunohistochemistry, and concentration of blood cells and cytokines.ConclusionWe found no indication of neuroprotection by therapeutic hypothermia in newborn piglets following lipopolysaccharide-sensitized hypoxia-ischemia. However, interpretation of the results is limited by the short observation period. Further studies are required to determine the potential clinical implications of these findings.