bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANACARDIUM OCCIDENTALE METHANOLIC NUT EXTRACT ATTENUATED TESTICULAR DYSFUNCTIONS IN HIGH-FAT DIET AND STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS
Authors: O. Ajao Folasade 
Published: January 2024

Background: Diabetes induces reproductive ailment and modern therapy is still unsatisfactory to combat diabetes-related reproductive impairment. This study investigated effect of Anacardium occidentale nut methanolic extract on testicular dysfunctions in high-fat diet (HFD)/streptozotocin-induced diabetic rats.
Materials and Methods: Forty adult male Wistar rats weighing (180 ± 20 g) were used for the experiment. Diabetes was induced with a repeated single dose of freshly prepared streptozotocin (35 mg/kgb.wt) injected intraperitoneally after fed with HFD for six weeks. The animals were randomly allotted into five groups, 8rats/group. Group I: control; Group II: diabetic control; Group III & IV: diabetic rats + low dose (100 mg/kgb.wt) and high dose (200 mg/kgb.wt) Anacardium occidentale nut methanolic extract; Group V: diabetic rats + 200 mg/kgbwp.o metformin for 28 days. Daily food and water intake with weekly body weight and fasting blood glucose were recorded throughout the experimental phase. On the last day of the experiment, the animals were sacrificed, blood sample were collected and testes was harvested for biochemical assay.
Results: Reproductive hormones, sperm parameters, testicular antioxidants, testicular B-cell lymphoma-2, testicular enzymes, body and weight of reproductive organs were significant (p<0.05) reduced in diabetic rats with significant (p<0.05) increase in blood glucose, insulin, sperm abnormalities, testicular caspase-3, testicular malondialdehyde (MDA), and food intake. Low dose (100 mg/kgb.wt) and high dose (200 mg/kgb.wt) Anacardium occidentale nut methanolic extract administration significantly (p<0.05) improved the testicular biochemical changes.
Conclusion: Anacardium occidentale nut attenuated testicular dysfunctions and could be a novel therapy for diabetes-induced reproductive dysfunctions.
Autoevaluación en estudiantes de medicina de primer nivel de la Universidad Técnica de Ambato
Authors: Loza Sánchez Edwin H. , Sandoval Espinoza Gabriela Fernanda 
Published: January 2024

El desarrollo del proceso enseñanza- aprendizaje siempre ha buscado estrategias para prevenir un fracaso escolar en cualquier nivel educativo, y de esta manera buscar soluciones para evitar un revés estudiantil. Esta investigación identificó en los estudiantes de medicina de primer nivel los puntos que influyeron para obtener un bajo rendimiento académico, de acuerdo a una autoevaluación cualitativa realizada y además reveló sus compromisos para mejorar este infortunio educativo. Se realizó un estudio retrospectivo transversal observacional cualitativo aplicado a una muestra de 116 estudiantes, seleccionados con muestreo aleatorio simple; mediante una encuesta de autoevaluación dirigida a los alumnos del primer nivel periodo académico octubre 2022 a marzo 2023. Se determinó que las debilidades y amenazas que influyen en el bajo rendimiento académico, son; el no poseer técnicas de estudio establecidas, déficits de conocimientos básicos referentes al nivel secundario, problemas psicológicos, dificultad de adaptación a los estudios universitarios, encontrarse lejos de su familia (soledad); además estableció en los alumnos el compromiso de adquirir buenos hábitos de estudio, evitar distractores, y obrar estrategias de aprendizaje.
Penataan Aset Tanah Bekas Hak Guna Bangunan di atas Hak Pengelolaan Pemerintah Provinsi Nusa Tenggara Barat di Lokasi Wisata Gili Trawangan
Authors: Abidin Asat , Sadino Sadino , Shebubakar Arina N. 
Published: January 2024

The Gili Trawangan tourism sector has the potential for extraordinary beauty, which can encourage the growth of other sectors such as culinary, accommodation, transportation, and tourism services. Seeing this potential, the NTB Provincial Government (Pemprov), as the holder of management rights, entered into a cooperation agreement with PT. Gili Trawangan Indah to build facilities and infrastructure by granting building use rights to the HPL. Unfortunately, PT. Gili Trawangan Indah was unable to fulfill the agreement, so the NTB Provincial Government proposed canceling the HGB, which was granted. Due to conditions in the field, HPL has been leased to other parties by PT. Gili Trawangan Indah, so HPL holders need to reorganize their assets. This research was carried out as normative legal research using statutory regulations and library materials. The results of this research indicate that the cancellation of the HGB was due to the fact that PT. Gili Trawangan Indah could not fulfill the agreement in the Decree on Granting Rights. The NTB Provincial Government can manage assets through a cooperation scheme based on an agreement or a land redistribution scheme coupled with the release of HPL. In cooperation, the party who controls the land can obtain use rights, business use rights, or building use rights according to the agreement.

Sektor pariwisata Gili Trawangan memiliki potensi keindahan luar biasa yang dapat mendorong pertumbuhan sektor lainnya seperti kuliner, penginapan, transportasi dan jasa wisata. Melihat potensi tersebut, Pemerintah Provinsi (Pemprov) NTB selaku pemegang Hak Pengelolaan melakukan perjanjian kerja sama dengan PT. Gili Trawangan Indah untuk membangun sarana dan prasarana dengan diberikannya Hak Guna Bangunan di atas HPL tersebut. Sayangnya, PT. Gili Trawangan Indah tidak dapat memenuhi perjanjian sehingga Pemprov NTB mengajukan pembatalan HGB dan dikabulkan. Kondisi di lapangan, HPL sudah disewakan dengan pihak-pihak lain oleh PT. Gili Trawangan Indah sehingga pemegang HPL perlu melakukan penataan asetnya kembali. Penelitian ini dilakukan secara penelitian hukum normatif dengan menggunakan peraturan perundangan dan bahan kepustakaan. Hasil penelitian ini menunjukkan bahwa pembatalan HGB dikarenakan PT. Gili Trawangan Indah tidak dapat memenuhi perjanjian pada SK Pemberian Hak. Penataan aset dapat dilakukan oleh Pemprov NTB dengan skema kerja sama berdasarkan perjanjian atau skema redistribusi tanah yang dibarengi dengan pelepasan HPL. Dalam kerja sama, pihak yang menguasai tanah bisa mendapatkan hak pakai, hak guna usaha, atau hak guna bangunan sesuai perjanjian.
ANALISIS DAMPAK DAN EFEKTIVITAS ADANYA UNDANG UNDANG NO 11 TAHUN 2020 TENTANG CIPTA KERJA PERPAJAKAN TERHADAP PERHITUNGAN PENGKREDITAN PAJAK MASUKAN PADA PT SUPRAJAYA DUARIBU SATU
Authors: Sofyan Hadi  , Jennifer  
Published: January 2024

Penelitian ini dilakukan untuk mengetahui apakah ada dampak dan efektivitas adanya undang undang cipta kerja perpajakan dalam perhitungan pengkreditan pajak masukan pada PT Suprajaya Duaribu Satu. Penelitian ini penting dilakukan agar PT Suprajaya Duaribu Satu dapat memahami dan menganalisis undang undang cipta kerja no 11 tahun 2020 atas pengkreditkan pajak masukan. Jenis penelitian ini adalah studi kasus. Penelitian ini mengunakan metode kualitatif dengan pendekatan deskriptif. Teknik Pengumpulan data mengunakan studi dokumentasi. Berdasarkan hasil dokumentasi, penelitian ini menunjukan bahwa pengkreditan pajak masukan pada PT Suprajaya Duaribu Satu sejak adanya undang undang cipta kerja no 11 tahun 2020 mengalami dampak/berdampak. Salah satunya adalah tentang pengkreditan pajak masukan yang dimana Pajak Masukan yang tidak dilaporkan dalam SPT Masa PPN yang diberitahukan dan/atau ditemukan pada waktu dilakukan pemeriksaan dapat dikreditkan. Salah satu poin yang tidak berdampak adalah tentang pengusaha yang dapat mengkreditkan pajak masukan sebelum di kukuhkan sebagai PKP, walaupun tidak semua poin poin perubahan yang ada pada undang undang cipta kerja no 11 tahun 2020 berdampak, tapi dengan adanya undang undang cipta kerja ini mengakibatkan pengkreditan pajak masukan pada PT Suprajaya Duaribu Satu mengalami perubahan sehingga menjadi lebih efektif.
Kata Kunci : Dampak, Efektivitas, Perhitungan Pengkreditan Pajak Masukan.
Stress-strain state of rod with heterogeneous structure (Novosibirsk)
Authors: Mishchenko A. V. 
Published: January 2024

Heterogeneous structures have a number of significant advantages over classical homogeneous. Their stress-strain state control allows to more effectively adapt the system to given thermal conditions and, as a result, additionally save weight and cost of the structure. The practical use of elements with heterogeneous structure, requires the creation of engineering calculation approaches with acceptable labor intensity, accuracy and versatility.Purpose: The improvement of design methods implying physical relations in problems of thermal power deformation of rods with heterogeneous structure.Design/methodology: The Timoshenko rod model design involves the approximation of transverse shear functions and membrane analogy of shear deformation in torsion. A threedimensional prismatic rod having a rectangular cross-section, is obtained from quasi-homogeneous parts (phases) made of various structural materials.Research findings: Theoretical calculations are obtained for thermal power spatial bending with tension, transverse shear and torsion. These equations contain stiffness characteristics of zero, first- and second-order tensile bending, shear and torsional stiffnesses of the section.Practical implication: These equations can be used to compactly formulate physical relations and the boundary value problem of spatial deformation of rods with heterogeneous structure.
MENGEDUKASI AKAN PENTINGNYA LINGKUNGAN BERSIH DAN SEHAT DENGAN MENGAPLIKASIKAN PENGELOLAAN SAMPAH BERBASIS PEMILAHAN SAMPAH DI MASYARAKAT DESA TENIGA
Authors: Budiarni Ameryya Tri , Yusuf Dedi , Fitria Ainun Alfina , Humaya Siti , Fidaris Nurul , Ismail Hijril , Rahmi Siti Atika , Syafril Syafril 
Published: January 2024

Kebersihan lingkungan merupakan tanggung jawab setiap warga masyarakat. Lingkungan yang sehat mencerminkan kualitas hidup masyarakat dan menjamin terjaganya kesehatan setiap individu. Program pengabdian masyarakat ini dilakukan di Desa Teniga, Kecamatan Tanjung, Kabupaten Lombok Utara. Salah satu masalah yang perlu diperhatikan di daerah ini adalah pencemaran lingkungan, yaitu sampah organik dan anorganik berupa limbah rumah tangga yang dapat merusak kebersihan lingkungan. Adapun tujuan pengabdian ini bertujuan untuk meningkatkan kepedulian masyarakat Desa teniga terhadap pentingnya kebersihan dan kesehatan lingkungan. Metode yang digunakan dalam pengabdian ini yaitu dengan pelaksanaan sosialisasi perihal pemilahan sampah yang tepat. Aksi lapangan diataranya dengan kegiatan pembagian plastik sampah sebagai wadah sementara yang di bagikam di rumah rumah masyarakat Desa Teniga, memonitoring tiga kali dalam satu minggu guna mengetahui masyarat telah tepat dalam pemilahan sampah. Pemilahan sampah organik dan Anorganik memanfaatkan sampah menjadi bahan kreasi atau kerajinan tangan untuk sampah anorganik dan Pembuatan gumelang untuk proses pembuatan kompos bagi sampah organik. Mengajak masyarakat gotong royong bersama membersihkan lingkungan di sekitar desa teniga. Kegiatan pengabdian dapat terlaksana dengan baik atas dukungan antusias dan kontribusi dari masyarakat di Desa Teniga. Kata kunci: Kesadaran, Masyarakat, Bersih
Researching approach toward circular economy on human resource performance management
Authors: Simion Luminita Cristina , Avasilcai Silvia 
Published: January 2024

Background The Industry 4.0 and 5.0 models are dynamic, still under research and unsolved implementation for industrial manufacturers. The paradigm “Green Deal” goals launched by the European Commission is apparently difficult to define concrete action plans. The good practices of the manufacturing industry are punctual. The health crisis of COVID-19 proves the necessity of a solid economy, with customized fields of industry-engines, located on countries proximity or associated. The productive operational chain with a multi-sequence activity processed by human labor becomes critical. Objective The paper aims to identify Industry 4.0 and 5.0 concepts in both scientific character and pragmatic relevance, useful for productive organizations performing in the current business with difficult predictability environment. Methods The methodology approach the grounded theories, combining the inductive and deductive methods. Next to the data collection provided from other authors research, a qualitative method apply to several case studies as empirical methodology to explore the situations in which the designed model has not a single set of outcomes. Results The principles CE become useful by transferring their meaning of waste reduction from material resources to human resources whether measuring tools are applied. I4.0 and I5.0 technical factors become means to recuperate the human factor within a culture of human centricity values. Conclusions By applying the CE principles, a mutual benefit organization-society is revealed, organization add values by hiring smart specialist from society I5.0 previously trained by organizational professional reconversion with technical support I4.0. The contribution is measured by reducing the waste, hence the cost of community unemployment rate.
Improved Cosine Similarity Measures and Extended TOPSIS for q-Rung Orthopair Fuzzy Sets: Applications in Green Technology Selection
Authors: Ünver Mehmet 
Published: January 2024

In this study, we present novel cosine similarity measures designed for \(q\)-rung orthopair fuzzy sets (\(q\)-ROFSs), offering a comprehensive analysis of both direction and magnitude aspects in fuzzy set representations. Unlike traditional cosine similarity measures, which primarily focus on the direction (cosine of the angle) between vectors, our proposed measures address this limitation by incorporating a lengths difference control term. This enhancement becomes crucial, especially when dealing with overlapping vector representations of \(q\)-ROFS components with a height difference, where traditional measures yield a similarity measure of \(1\). We demonstrate the effectiveness of these improved cosine similarity measures, showcasing their superiority not only over traditional counterparts for \(q\)-ROFSs but also in enhancing existing measures for intuitionistic fuzzy sets and Pythagorean fuzzy sets. The proposed measures consist of an average or Choquet integral of two components. The first component quantifies the cosine similarity between two \(q\)-ROFSs at each element, while the second component captures the difference in lengths between the vector representations of these \(q\)-ROFSs at the same element. This innovative length-difference term ensures sensitivity to variations in both direction and magnitude, making the measures well-suited for applications where both aspects are crucial. The Choquet integral-based measure further considers interactions among elements, enhancing sensitivity in diverse applications. In addition to introducing these cosine similarity measures, we extend our contributions to the realm of multi-criteria group decision making (MCGDM) through an extended The Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) methodology. The proposed TOPSIS methodology is applied to a real-world problem in green technology selection, providing a comprehensive evaluation framework. Our comparative analysis with some other MCGDM methods further highlights the effectiveness of our proposed approach.
PROBLEMATIKA DAN SOLUSI PELAKSANAAN PEMBELAJARAN TEMATIK PADA GURU KELAS RENDAH DI SD NEGERI KOTA TERNATE
Authors: Somadayo Samsu , Wulandari Selvi , Ibrahim Filia , Aprianti Aprianti 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui problematika pelaksanaan pembelajaran tematik di SDNegeri Kota Ternate yang dimulai dari perencanaan, pelaksanaan dan evaluasi pembelajaran, mendeskripsikan cara mengatasi problem yang dialami guru dan siswa selama pembelajaran. Problematika pelaksanaan pembelajaran tematik di SD Negeri Kota ternate dapat disimpulkan bahwa; Problem yang dialami guru yaitu: guru kurang kreatif dalam memilih media, kondisi kelas yang kurang maksimal, metode pembelajaran kurang bervariasi, keterbatsan sarana dan prasarana yang kurang memadai, problem perencanaan pembelajaran, dan problem evaluasi pembelajaran tematik. Problem yang dialami siswa sebagai berikut: kemampuan baca tulis siswa yang lamban, kurang aktif dan antusias dalam proses pembelajaran dan kehadiran siswa yang kurang disekolah. Solusi yang ditempuh untuk mengatasi problematika dalam pelaksanaan pembelajaran tematik terkait problematika pendidik (guru) yakni: Guru harus kreatif dalam memilih media pembelajaran; guru harus mampu mengelolaan kelas; memilih metode pembelajaran yang variatif; memanfaatkan sarana dan prasarana yang ada secara optimal; memperbaiki Perencanaan Pembelajaran; dan melaksanakan Evaluasi Pembelajaran Tematik. Solusi yang ditempuh untuk mengatasi problematika dalam pelaksanaan pembelajaran tematik terkait siswa yakni: meningkatkan kemampuan baca tulis siswa; membuat siswa aktif dan antusias dalam proses pembelajaran; dan meningkatkan efektivitas kehadiran siswa di sekolah. ini semua dapat dilakukan pendampingan/pelatihan guru di SD Negeri Kota Ternate.
RxNorm for drug name normalization: a case study of prescription opioids in the FDA adverse events reporting system
Authors: Le Huyen , Chen Ru , Harris Stephen , Fang Hong , Lyn-Cook Beverly , Hong Huixiao , Ge Weigong , Rogers Paul , Tong Weida , Zou Wen 
Published: January 2024

Numerous studies have been conducted on the US Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) database to assess post-marketing reporting rates for drug safety review and risk assessment. However, the drug names in the adverse event (AE) reports from FAERS were heterogeneous due to a lack of uniformity of information submitted mandatorily by pharmaceutical companies and voluntarily by patients, healthcare professionals, and the public. Studies using FAERS and other spontaneous reporting AEs database without drug name normalization may encounter incomplete collection of AE reports from non-standard drug names and the accuracies of the results might be impacted. In this study, we demonstrated applicability of RxNorm, developed by the National Library of Medicine, for drug name normalization in FAERS. Using prescription opioids as a case study, we used RxNorm application program interface (API) to map all FDA-approved prescription opioids described in FAERS AE reports to their equivalent RxNorm Concept Unique Identifiers (RxCUIs) and RxNorm names. The different names of the opioids were then extracted, and their usage frequencies were calculated in collection of more than 14.9 million AE reports for 13 FDA-approved prescription opioid classes, reported over 17 years. The results showed that a significant number of different names were consistently used for opioids in FAERS reports, with 2,086 different names (out of 7,892) used at least three times and 842 different names used at least ten times for each of the 92 RxNorm names of FDA-approved opioids. Our method of using RxNorm API mapping was confirmed to be efficient and accurate and capable of reducing the heterogeneity of prescription opioid names significantly in the AE reports in FAERS; meanwhile, it is expected to have a broad application to different sets of drug names from any database where drug names are diverse and unnormalized. It is expected to be able to automatically standardize and link different representations of the same drugs to build an intact and high-quality database for diverse research, particularly postmarketing data analysis in pharmacovigilance initiatives.
Co-digestion approach for enhancement of biogas production by mixture of untreated napier grass and industrial hydrolyzed food waste
Authors: Kriswantoro Jayen Aris , Pan Kuan-Yin , Chu Chen-Yeon 
Published: January 2024

The co-digestion of untreated Napier grass (NG) and industrial hydrolyzed food waste (FW) was carried out in the batch reactor to investigate the effect of substrate ratios on biogas production performance. Two-stage anaerobic digestion was performed with an initial substrate concentration of 5 g VSadded/L and a Food to Microorganism Ratio (F/M) of 0.84. The 1:1 ratio of the NG and FW showed the optimum performances on biogas production yield with a value of 1,161.33 mL/g VSadded after 60 days of digestion. This was followed by the data on methane yield and concentration were 614.37 mL/g VSadded and 67.29%, respectively. The results were similar to the simulation results using a modified Gompertz model, which had a higher potential methane production and maximum production rate, as well as a shorter lag phase and a coefficient of determination of 0.9945. These findings indicated that the co-digestion of Napier grass and hydrolyzed food waste can enhance biogas production in two-stage anaerobic digestion.
Differences in left ventricular myocardial function and infarct size in female patients with ST elevation myocardial infarction and spontaneous coronary artery dissection
Authors: Krljanac Gordana , Apostolović Svetlana , Polovina Marija , Maksimović Ružica , Nedeljković Arsenović Olga , Đorđevic Nemanja , Stanković Stefan , Savić Lidija , Ušćumlić Ana , Stanković Sanja , Ašanin Milika 
Published: January 2024

IntroductionDifferences in pathophysiology, clinical presentation, and natural course of ST-elevation myocardial infarction in female patients due to either spontaneous dissection (SCAD-STEMI) or atherothrombotic occlusion (type 1 STEMI) have been discussed. Current knowledge on differences in left ventricular myocardial function and infarct size is limited. The aim of this study was to assess baseline clinical characteristics, imaging findings, and therapeutic approach and to compare differences in echocardiographic findings at baseline and 3-month follow-up in patients with SCAD-STEMI and type 1 STEMI.MethodsThis was a prospective multicenter study of 32 female patients (18–55 years of age) presenting with either SCAD-STEMI due to left anterior descending coronary artery (LAD) dissection or type 1 STEMI due to atherothrombotic LAD occlusion.ResultsThe two groups were similar in age, risk factors, comorbidities, and complications. SCAD-STEMI patients more often had Thrombolysis in Myocardial Infarction 3 flow, while type 1 STEMI patients were more often treated with percutaneous coronary intervention and dual antiplatelet therapy. Baseline mean left ventricular (LV) ejection fraction (LVEF) was similar in the two groups (48.0% vs. 48.6%, p = 0.881), but there was a significant difference at the 3-month follow-up, driven by an improvement in LVEF in SCAD-STEMI compared to type 1 STEMI patients (Δ LVEF 10.1 ± 5.3% vs. 1.8 ± 5.1%, p = 0.002). LV global longitudinal strain was slightly improved in both groups at follow-up; however, the improvement was not significantly different between groups (−4.6 ± 2.9% vs. −2.0 ± 2.8%, p = 0.055).ConclusionsThe results suggest that female patients with SCAD-STEMI are more likely to experience improvement in LV systolic function than type 1 STEMI patients.