bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic Hernioplasty versus Conventional Hernioplasty (Shouldice): Results of a Prospective Randomized Trial
Authors: Lorenz Dietmar , Stark Eberhard , Oestreich Kerstin , Richter Axel 
Published: August 2002

Abstract.The results of our randomized trial of 176 patients comprising primary hernias [Shouldice versus transabdominal preperitoneal approach (TAPP)] showed only slight advantages for the laparoscopically operated group compared to the conventionally operated group: less subjective pain (significant only on fifth postoperative day, p < 0.05), reduced analgesic requirement (significant only on third postoperative day, p < 0.05), significantly shorter duration of hospitalization (4 days vs. 6 days, p < 0.05) and faster return to work (27 days vs. 34 days, NS). Regarding the incidence of recurrences, there was no significant difference between the groups (two recurrences vs. one recurrence) within a follow‐up period of 2 years. Postoperative morbidity was similar and the total cost was less for the TAPP group.
Novel Approaches to Tackling Malarial Drug Resistance Using Yeast
Authors: Sibley Carol Hopkins , MacReadie Ian 
Published: August 2002

AbstractYeasts have a justified reputation as one of the world's most versatile organisms. Baker's yeast continues to live up to this recognition by joining the war against malaria. Yeast can now be used to study antifolate drug resistance patterns that depend on the dihydrofolate reductase enzyme (DHFR) from the malaria parasite.
Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier
Authors: Beygi Mohammad , Oroojalian Fatemeh , Azizi‐Arani Soheil , Hosseini Seyed Samad , Mokhtarzadeh Ahad , Kesharwani Prashant , Sahebkar Amirhossein 
Published: January 2024

AbstractThe blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent junctions that regulates the transport of various materials and substances between the blood vasculature and the central nervous system (CNS). However, in cases of brain diseases, BBB's protective and regulatory effects hamper therapeutics from reaching affected sites in sufficient quantities. This has so far been a leading challenge in treating CNS diseases and disorders. For this problem to be overcome, recent research has sought to develop novel modalities to achieve efficient therapy and alleviate associated symptoms. Therefore, numerous strategies have operated in recent years to address the limitations of traditional and invasive methods, including poor brain penetration and serious side effects. As a desperately in‐demand technology, nanotheranostics has particularly shown promising results. Herein, this review reports recent advancements in CNS nanotheranostics and novel techniques and nanotechnology‐based strategies developed for treating neurodegenerative disorders. The study provides comprehensive data on the subject to be used for future studies for the therapy and management of CNS disorders and diseases.
Self‐Assembled Robust Interfacial Layer for Dendrite‐Free and Flexible Zinc‐Based Energy Storage
Authors: Zheng Zhiyuan , Ren Danyang , Li Yang , Kang Fulian , Li Xu , Peng Xinya , Dong Liubing 
Published: January 2024

AbstractAqueous zinc‐based energy storage systems (Zn‐ESSs) with intrinsic safety and good electrochemical performance are promising power suppliers for flexible electronics, whereas unstable zinc anodes especially in flexible Zn‐ESSs pose a challenge. Herein, a self‐assembled robust interfacial layer to achieve stable zinc anodes in non‐flexible and flexible Zn‐ESSs is reported. Specifically, zinc anodes and their slowly‐released Zn2+ simultaneously interact with tannic acid molecules in ethanol–water solutions, triggering the self‐assembly of a tannic acid/Zn2+ complex interfacial layer (CIL) that firmly anchors on the zinc anodes. The CIL containing abundant carboxyl and phenolic hydroxyl functional groups provides rich zincophilic sites to homogenize Zn2+ flux and accelerate Zn2+ desolvation‐deposition, and traps H+/H2O species to prevent them from corroding zinc anodes, thereby stabilizing the zinc deposition interface. Consequently, the CIL@Zn anodes present superior stability with an operation lifetime exceeding 700 h even at 5 mA cm−2 (28 times longer than that of bare zinc anodes) and ultrahigh cumulative plated capacity of ≈1.8 Ah cm−2. The firm anchoring of the CIL enables the CIL@Zn anodes to endure diverse deformations, thus realizing highly flexible CIL@Zn anode‐based Zn‐ESSs. This work provides thinking in designing stable and flexible zinc anodes, promoting the development of flexible zinc‐based energy storage.
A Visible Light Cross‐Linked Underwater Hydrogel Adhesive with Biodegradation and Hemostatic Ability
Authors: Liang Min , Wei Dandan , Ren Pengfei , Xu Li , Tao Yinghua , Yang Liuxin , Jiao Guanhua , Zhang Tianzhu , Serizawa Takeshi 
Published: January 2024

AbstractHydrogel adhesives with integrated functionalities are still required to match their ever‐expanding practical applications in the field of tissue repair and regeneration. A simple and effective safety strategy is reported, involving an in situ injectable polymer precursor and visible light‐induced cross‐linking. This strategy enables the preparation of a hydrogel adhesive in a physiological environment, offering wet adhesion to tissue surfaces, molecular flexibility, biodegradability, biocompatibility, efficient hemostatic performance, and the ability to facilitate liver injury repair. The proposed one‐step preparation process of this polymer precursor involves the mixing of gelatin methacryloyl (GelMA), poly(thioctic acid) [P(TA)], poly(acrylic acid)/amorphous calcium phosphate (PAAc/ACP, PA) and FDA‐approved photoinitiator solution, and a subsequent visible light irradiation after in situ injection into target tissues that resulted in a chemically‐physically cross‐linked hybrid hydrogel adhesive. Such a combined strategy shows promise for medical scenarios, such as uncontrollable post‐traumatic bleeding.
NIR‐Light‐Triggered Mild‐Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy
Authors: Chen Mingmao , Fu Yulei , Liu Yan , Zhang Baihe , Song Xiaorong , Chen Xinchun , Zhu Zhengjia , Gao Hang , Yang Jianmin , Shi Xianai 
Published: January 2024

AbstractCurrently, cisplatin resistance has been recognized as a multistep cascade process for its clinical chemotherapy failure. Hitherto, it remains challenging to develop a feasible and promising strategy to overcome the cascade drug resistance (CDR) issue for achieving fundamentally improved chemotherapeutic efficacy. Herein, a novel self‐assembled nanoagent is proposed, which is constructed by Pt(IV) prodrug, cyanine dye (cypate), and gadolinium ion (Gd3+), for systematically conquering the cisplatin resistance by employing near‐infrared (NIR) light activated mild‐temperature hyperthermia in tumor targets. The proposed nanoagents exhibit high photostability, GSH/H+‐responsive dissociation, preferable photothermal conversion, and enhanced cellular uptake performance. In particular, upon 785‐nm NIR light irradiation, the generated mild temperature of ≈ 43 °C overtly improves the cell membrane permeability and drug uptake, accelerates the disruption of intracellular redox balance, and apparently enhances the formation of Pt‐DNA adducts, thereby effectively overcoming the CDR issue and achieves highly improved therapeutic efficacy for cisplatin‐resistant tumor ablation.
Suppressing the Dark Current While Improving the Quantum Efficiency in Shortwave Infrared Organic Photodetectors Through Naphthalenediimide‐Based Interlayer
Authors: Tsai Kuen‐Wei , Chen Min‐Hsien , Suthar Gajendra , Hsiao Yu‐Tang , Cheng Lin‐Chieh , Liao Chuang‐Yi , Chen Fang‐Chung , Chu Chih‐Wei , Chang Yi‐Ming 
Published: January 2024

AbstractThe significance of shortwave infrared (SWIR) photodetectors spans across various applications. Nevertheless, the limited spectral response of silicon‐based photodetectors and the high cost associated with materials like germanium (Ge) have impeded the widespread adoption of SWIR sensors, particularly in the realm of consumer electronics. This study explores the transformative impact of incorporating a cross‐linkable naphthalenediimide (c‐NDI) as both an electron transporting layer and a hole blocking layer in organic photodetectors (OPDs). The introduction of c‐NDI as an interlayer leads to substantial enhancements in SWIR OPD performance, particularly in terms of reducing dark current and augmenting external quantum efficiency. These improvements are most notable in ultra‐narrow bandgap SWIR systems, where c‐NDI demonstrates superior hole‐blocking capabilities. Besides, OPDs with c‐NDI interlayers also exhibit exceptional stability over time when compared to OPDs based on zinc oxide interlayer, underscoring c‐NDI‘s versatility as an interlayer. Most importantly, when compared to a commercially available Ge photodetector, c‐NDI‐based OPD demonstrates competitive detectivity, achieving 2.67 × 1011 Jones at a wavelength of 1300 nm. This performance even surpasses that of the Ge photodetector, highlighting the substantial potential of OPDs for SWIR imaging applications.
Ru(II) Catalyzed Oxidative Dehydrogenative Annulation and Spirocyclization of Isoquinolones with N‐Substituted Maleimides
Authors: Seal Kaushik , Banerji Biswadip 
Published: January 2024

AbstractA Ruthenium(II) catalyzed additive‐free oxidative, dehydrogenative annulation of different malemides on 3,4‐disubstituted isoquinolone to afford fused and spiro‐cyclized isoquinolo‐isoquinolone and isoindolo‐isoquinolone derivatives is reported here. By simply changing solvent and oxidizing agents, under two different conditions, this methodology produced two different poly‐N‐heterocyclized products. Isoquinolone‐NH was strategically used as the internal directing group in the ortho C−H activation using Ru(II) catalyst. Mechanistically dehydrogenative, oxidative C−C followed by C−N cross‐coupling and aza‐michael reaction pathway led to the corresponding fused and spiro‐products respectively. A diversified library of eighty‐one (81) such two products were synthesized by employing this methodology. The fused and the spirocyclized polyheterocyclic compounds absorbed at λmax 240–270 nm range, however only spiro‐compounds produced blue fluorescence at λem 391–450 nm range.
Vanadate‐Based Fibrous Electrode Materials for High Performance Aqueous Zinc Ion Batteries
Authors: Wang Qimeng , Wu Jianping , Wang Mingming , Yu Haizhou , Qiu Xiaoyan , Chen Wei 
Published: January 2024

AbstractAqueous zinc‐ion batteries (AZIBs) are considered as attractive energy storage systems with great promise owing to their low cost, environmental friendliness and high safety. Nevertheless, cathode materials with stable structure and rapid diffusion of zinc ions are in great demand for AZIBs. In this work, a new kind of potassium vanadate compound (KV3O8) is synthesized with fibrous morphology as an excellent cathode material for AZIBs, which shows outstanding electrochemical performance. KV3O8 exhibits a high discharge capacity of 556.4 mAh g−1 at 0.8 A g−1, and the capacity retention is 81.3% at 6 A g−1 even after a long cycle life of 5000 cycles. The excellent performance of the KV3O8 cathode is benefited from the structural stability, sufficient active sites, and high conductivity, which is revealed by in situ X‐ray diffraction and various other characterizations. This work offers a new design strategy into fabricating high efficiency cathode materials for AZIBs and beyond.
Multi‐Facet Passivation of Ternary Colloidal Quantum Dot Enabled by Quadruple‐Ligand Ensemble toward Efficient Lead‐Free Optoelectronics
Authors: Kim Dongeon , Cho Gaeun , Kim Yun Hoo , Kwon Ji Hyun , Oh Yeonwoo , Yang Minjung , Jee Seungin , Lee In Suh , Si Min‐Jae , Jung Yujin , Yang Ho Yeon , Ahn Yongnam , Kim Beom‐Kwan , Kim Changjo , Kim Han Seul , Baek Se‐Woong 
Published: January 2024

AbstractSolution‐processed ternary‐compound semiconductor AgBiS2 colloidal quantum dots (CQDs) are promising light‐absorbing materials owing to their nontoxicity and high absorption coefficient (>106 cm−1). However, rational strategies to passivate multi‐facet of ternary‐compound CQDs and manufacture stable CQD inks have not yet been proposed. In this paper, a ligand passivation strategy is proposed using a solution‐phase ligand exchange method. A quadruple‐ligand ensemble is employed to demonstrate multifaceted passivation on AgBiS2 CQDs and a highly stable CQD ink. Density functional theory studies reveal the secondary cation adsorption of silver halide passivation, indicating the synergistic passivation of the ligand ensemble. This yields a low trap density in CQD solids, improving the power conversion efficiency to 8.1% by 53% in CQD solar cells. Furthermore, the proposed device exhibits the fastest response time of 400 ns among all reported AgBiS2 devices, demonstrating its potential for efficient lead‐free optoelectronics.
Epitaxial Nucleation of NaxFeFe(CN)6@rGO with Improved Lattice Regularity as Ultrahigh‐Rate Cathode for Sodium‐Ion Batteries
Authors: Tang Yun , Wang Lei , Hu Jianwei , Chen Manlin , Zhou Min , Wang Kangli , Jiang Kai 
Published: January 2024

AbstractAlthough Prussian blue analogues are the promising candidate cathode materials for the Na‐ion batteries for the grid storage due to 3D open‐framework structure and large interstitial “A” sites, high content of defects in the crystals obtained in the conventional strategy severely impede Na+ migration, leading to an unsatisfactory power density. Here a novel epitaxial nucleation‐assisted controlled crystallization approach to eliminate the structural defects of NaFeHCF crystals is reported. Due to their limited lattice misfit of only 4.87% (< 5%) between the graphene and NaFeHCF as well as the electronegativity of the functional groups (─COOH, ─OH, ─CH(O)CH─), GO can act as the nucleation and subsequent epitaxial growth platform of NaFeHCF, which results in a unique one‐corner‐cut cubic nano‐crystals morphologies with much decreased contents of defects (0.08 per formula unit). This enhanced lattice regularity significantly enhanced the speedy diffusion of Na cations (by 5 times) in the nanocrystals, resulting in the unprecedented rate capability of 96.8 mAh g−1 at an ultra‐high rate of 9 A g−1 (39 s, 23228 W kg−1), which is far exceeding that of any previously reported PBA‐based cathodes to the knowledge, authenticating its superiority as a candidate for high‐power sodium‐ion batteries for the reliable grid energy storage.
3D Printed Sodium‐Ion Batteries via Ternary Anode Design Affording Hybrid Ion Storage Mechanism
Authors: He Zeyu , Han Tao , Liu Wenfeng , Zhou Chucheng , Sun Jingyu , Zhou Ji , Li Ya‐yun 
Published: January 2024

AbstractSodium‐ion batteries (SIB), as one of the most appealing grid‐scale energy storage devices, have to deal with the trade‐off between the capacity output and rate performance. Utilizing 3D‐printed (3DP) anode materials with hybrid sodium storage mechanism and elevated mass loading is promising yet poorly explored. Herein, the design of a prototype ternary composite is reported, MoS2@Bi/N‐doped carbon, as a sodium storage candidate to achieve high reversible capacity (604 mAh g−1 at 0.1 A g−1 with an initial output of 709 mAh g−1) and outstanding rate capability (169.6 mAh g−1 at 15 A g−1), outperforming the state‐of‐the‐art reports. This is realized by delicate structural and interfacial engineering of the composite anode, markedly synergizing the conversion‐typed MoS2, alloy‐typed Bi, and adsorption‐typed N‐doped carbon. Theoretical simulations and operando instrumental analysis elaborate the reasons of the boosted electrochemical performance. Encouragingly, a fully 3DP SIB affording an areal mass loading of up to 11.7 mg cm−2 is demonstrated, retaining a capacity of 114 mAh g−1 at 1.0 A g−1. This work would facilitate the design of 3DP SIB devices with the employment of advanced electrodes harnessing hybrid ion storage features.
Sulfonium Rearrangements Enable the Direct Preparation of Sulfenyl Imidinium Salts
Authors: Gonçalves Carlos R. , Klose Immo , Placidi Simone , Kaiser Daniel , Maulide Nuno 
Published: January 2024

AbstractSulfenyl imidinium salts are a virtually unexplored class of intermediates in organic chemistry. Herein, we demonstrate how sulfonium rearrangements can be deployed to access these versatile synthetic intermediates, bearing three contiguous (and congested) stereogenic centers, with high levels of selectivity. The synthetic value of the scaffold was unraveled by selective transformations into a range of building blocks, including 1,4‐dicarbonyl derivatives and sulfonolactones.
Bio‐Inspired Trace Hydroxyl‐Rich Electrolyte Additives for High‐Rate and Stable Zn‐Ion Batteries at Low Temperatures
Authors: Bu Fan , Gao Yong , Zhao Wenbo , Cao Qinghe , Deng Yifan , Chen Jipeng , Pu Jie , Yang Jiayu , Wang Yuxuan , Yang Nute , Meng Ting , Liu Xiangye , Guan Cao 
Published: January 2024

AbstractHigh‐rate and stable Zn‐ion batteries working at low temperatures are highly desirable for practical applications, but are challenged by sluggish kinetics and severe corrosion. Herein, inspired by frost‐resistant plants, we report trace hydroxyl‐rich electrolyte additives that implement a dual remodeling effect for high‐performance low‐temperature Zn‐ion batteries. The additive with high Zn absorbability not only remodels Zn2+ primary solvent shell by alternating H2O molecules, but also forms a shielding layer thus remodeling the Zn surface, which effectively enhances fast Zn2+ de‐solvation reaction kinetics and prohibits Zn anode corrosion. Taking trace α‐D‐glucose (αDG) as a demonstration, the electrolyte obtains a low freezing point of −55.3 °C, and the Zn//Zn cell can stably cycle for 2000 h at 5 mA cm−2 under −25 °C, with a high cumulative capacity of 5000 mAh cm−2. A full battery that stably operates for 10000 cycles at −50 °C is also demonstrated.
Synthesis of Chiral Pyrene‐Based 1,4‐Dithiins
Authors: Keck Christoph , Rominger Frank , Mastalerz Michael 
Published: January 2024

AbstractThe 1,4‐dithiin motif is known for its reversible redox properties to generate radical cations and diradical dications and thus is interesting for organic electronic applications. However, examples where this motif is embedded into chiral larger fused aromatic compounds are very rare. Here we describe the syntheses of several structurally related pyrene fused dithiins and their spectroscopic investigations with a focus on tuning circular dichroism, with respect to the g values, depending on their connectivity.
Room temperature‐responsive poly(vinyl hydroxyalkyl ether‐alt‐dialkyl maleate)‐based vitrimers with dynamic boronic ester bonds
Authors: Wang Guochen , Xu Weiping , Zhang Yanxin , Chen Dong , Ma Yuhong , Song Changtong , Yang Wantai 
Published: January 2024

AbstractDynamic BO bonds are often applied to fabricate reversible‐cross‐linking and reprocessable polymer networks due to their high thermodynamic stability and kinetic tunability. However, it is still difficult to tailor boronic ester polymers, which have both excellent mechanical and self‐healing properties in the absence of external stimuli. To address the above challenge, a range of room‐temperature self‐healable vitrimers are prepared by the reactions of various poly(vinyl hydroxyalkyl ether‐alt‐dialkyl maleate) copolymers and 1,4‐phenyldiboronic acid. The dynamic cross‐linking networks offer the as‐prepared vitrimers superior mechanical properties and thermostability. Because of the presence of dynamic boronic ester bonds, the networks also demonstrated self‐healing (the tensile strength recovered to 83% after 3 days at room temperature) and reprocessing capabilities (no significant change in tensile strength after thrice process recycles). Moreover, the vitrimers have potential as promising damping materials with wide temperature windows around room temperature. For example, the vitrimer of poly(ethylene glycol monovinyl ether‐alt‐dibutyl maleate) and 1,4‐phenyldiboronic acid demonstrates its tanδmax 1.18, Tg = 6.2°C and effective damping temperature range is from −16.4 to 48.5°C.
Different development and fecundity between Spodoptera frugiperda USA and China populations, influenced by ecdysone‐related genes
Authors: Choi Du‐Yeol , Mo Hyoung‐ho , Park Youngjin 
Published: January 2024

AbstractThe fall armyworm (FAW), Spodoptera frugiperda, is one of the most harmful plant pests in the world and is globally distributed from the American continent to the Asian region. The FAW USA population (Sf‐USA) and China population (Sf‐CHN), which belong to corn strain, showed different developmental periods and fecundity rates in lab conditions. Sf‐USA had faster development and higher fecundity compared with Sf‐CHN. To examine these differences, transcriptomic data from two FAW populations were analyzed and compared. Twelve gigabytes of transcripts were read from each sample and 21,258 differentially expressed genes (DEGs) were detected. DEGs with log2 fold change ≥ 2 were identified and compared in two populations. In comparison to the Sf‐CHN, we discovered that 3471 and 3851 individual DEGs upregulated and downregulated, respectively. Comparing transcriptome profiles for differential gene expression revealed several DEGs, including 39 of ecdysone (E)‐, 25 of juvenile hormone‐, and 15 of insulin‐related genes. We selected six of E‐related genes, such as Neverland, Shade, Ecdysone receptor, Ecdysone‐inducible protein 74 (E74), E75, and E78 from DEGs. Gene expressions were suppressed by RNA interference to confirm the physiological functions of the selected genes from Sf‐USA. The Sf‐USA showed developmental retardation and a decrease in fecundity rate by suppression of E‐related genes. These findings show that biological characteristics between Sf‐USA and Sf‐CHN are influenced by E‐related genes.
K64 acetylation of heat shock protein 90 suppresses nucleopolyhedrovirus replication in Bombyx mori
Authors: Zhang Xizhen , Ma Shiyi , Gu Chaoguang , Hu Miao , Miao Meng , Quan Yanping , Yu Wei 
Published: January 2024

AbstractHSP90 is a highly conserved chaperone that facilitates the proliferation of many viruses, including silkworm (bombyx mori) nucleopolyhedrovirus (BmNPV), but the underlying regulatory mechanism was unclear. We found that suppression of HSP90 by 17‐AAG, a HSP90‐specific inhibitor, significantly reduced the expression of BmNPV capsid protein gp64 and viral genome replication, whereas overexpression of B. mori HSP90(BmHSP90) promoted BmNPV replication. Furthermore, in a recent study of the lysine acetylome of B. mori infected with BmNPV, we focused on the reduced viral proliferation due to changes of BmHSP90 lysine acetylation. Site‐directed introduction of acetylated (K/Q) or deacetylated (K/R) mimic mutations into BmHSP90 revealed that lysine 64 (K64) acetylation activated the JAK/STAT pathway and reduced BmHSP90 ATPase activity, leading to diminished chaperone activity and ultimately inhibiting BmNPV proliferation. In this study, a single lysine 64 acetylation change of BmHSP90 was elucidated as a model of posttranslational modifications occurring in the wake of host‐virus interactions, providing novel insights into potential antiviral strategies.