bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomimetic Nanomaterials for the Immunomodulation of the Cardiosplenic Axis Postmyocardial Infarction
Authors: Bose Rajendran JC , Kessinger Chase W. , Dhammu Tajinder , Singh Toolika , Shealy Miller W. , Ha Khanh , Collandra Rena , Himbert Sebastian , Garcia Fernando J. , Oleinik Natalia , Xu Bing , Vikas  , Kontaridis Maria I. , Rheinstädter Maikel C. , Ogretmen Besim , Menick Donald R. , McCarthy Jason R. 
Published: November 2023

AbstractThe spleen is an important mediator of both adaptive and innate immunity. As such, attempts to modulate the immune response provided by the spleen may be conducive to improved outcomes for numerous diseases throughout the body. Here, biomimicry is used to rationally design nanomaterials capable of splenic retention and immunomodulation for the treatment of disease in a distant organ, the postinfarct heart. Engineered senescent erythrocyte‐derived nanotheranostic (eSENTs) are generated, demonstrating significant uptake by the immune cells of the spleen including T and B cells, as well as monocytes and macrophages. When loaded with suberoylanilide hydroxamic acid (SAHA), the nanoagents exhibit a potent therapeutic effect, reducing infarct size by 14% at 72 h postmyocardial infarction when given as a single intravenous dose 2 h after injury. These results are supportive of the hypothesis that RBC‐derived biomimicry may provide new approaches for the targeted modulation of the pathological processes involved in myocardial infarction, thus further experiments to decisively confirm the mechanisms of action are currently underway. This novel concept may have far‐reaching applicability for the treatment of a number of both acute and chronic conditions where the immune responses are either stimulated or suppressed by the splenic (auto)immune milieu.
Interface Engineering for Highly Efficient and Stable Perovskite Solar Cells
Authors: Zhao Chenxu , Zhang Hong , Krishna Anurag , Xu Jia , Yao Jianxi 
Published: November 2023

AbstractThe ongoing global research and development efforts on perovskite solar cells (PSCs) have led the power conversion efficiency to a high record of 26.1%. The optimization of PSC processing methods, the development of new compositions, and the introduction of passivation strategies are key factors behind the meteoric rise in performance. In particular, defect passivation and mitigation of ion migration via molecular engineering of the interfaces have played a critical role in enhancing the photovoltaic performance and operational stability of PSCs. The key interface engineering strategies enabling highly stable and efficient PSCs are focused here. The interface chemistry and the deleterious impact associated with it are discussed. The molecular design of effective modulators to mitigate the negative effects of perovskite interfaces is elaborated along with advanced characterization techniques to probe the interfaces. The progress of interface modification by multiple strategies is presented, and different modulator designs that are proven to be effective in mitigating the negative effects of perovskite interfaces are highlighted. Moreover, the main properties of effective interface modification strategies are summarized, and general design principles are deduced for future applications. Here, important insights are provided into the fields of material chemistry, physical chemistry, and optoelectronics.
Selenium Dioxide‐Promoted Regioselective Synthesis of Multi‐Substituted Furans from Terminal Alkynes and Aldehydes
Authors: Liu Yafeng , Sun Fengkai , An Zhenyu , Miao Man , Guo Xin , Li Chonglong 
Published: November 2023

AbstractA SeO2‐mediated regioselective synthesis of multi‐substituted furans has been achieved through intermolecular cyclization of terminal alkynes with aldehydes. The developed methodology used commercially available starting materials and afforded various 2,3,5‐triarylfurans.
Cobalt‐Catalyzed Intramolecular Cycloadditions of Alkenylidenecyclopropanes with Alkenes and Dienes
Authors: da Concepción Eduardo , Fernández Israel , Mascareñas José L. , López Fernando 
Published: November 2023

AbstractLow‐valent cobalt complexes equipped with phosphorous type of ligands can promote the intramolecular (3+2) cycloaddition of alkylidenecyclopropanes (ACPs) with alkenes and with allenes. Dienes can also be used as partners, but they afford seven‐membered cycloadducts. The reactions are fully diastereoselective and, in some cases, we also observed moderate enantioselectivities, especially when using chiral phosphite ligands.
Transition‐Metal Free, One Pot Synthesis of Selenoesters via Reaction of Alkyl Selenides and Acyl Chlorides
Authors: Duarte Juliana S. , De Oliveira Sandynara A. , Da Silva Emily C. O. , De Jesus Andreia P. V. , Vasconcelos Leonardo G. , De Sousa Júnior Paulo T. , Rafique Jamal , Saba Sumbal , Stein André L. 
Published: November 2023

AbstractHerein, we report a new and efficient method for the synthesis of selenoesters by a direct coupling reaction of alkyl selenides with acyl chlorides in ethanol under transition metal‐free conditions. This nucleophilic acyl substitution afforded selenoesters in good yields. Traditionally, synthesis of selenoesters involve the reaction of acyl chlorides with an organoselenium anions generated in situ through the reductive cleavage of previously prepared diselenides. Our one‐pot approach avoids the pre‐preparation of diselenides and operated in atom‐economical and environmentally friendly conditions. The synthetic utility of these selenoesters was studied using Se‐butyl benzoselenoate as substrate in a Sonogashira‐type cross‐coupling reaction.
sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study
Authors: Butts Brittany , Huang Hanfeng , Hu William T. , Kehoe Patrick Gavin , Miners James Scott , Verble Danielle D. , Zetterberg Henrik , Zhao Liping , Trotti Lynn Marie , Benameur Karima , Scorr Laura M. , Wharton Whitney 
Published: November 2023

AbstractINTRODUCTIONThere remains an urgent need to identify preclinical pathophysiological mechanisms of Alzheimer's disease (AD) development in high‐risk, racially diverse populations. We explored the relationship between cerebrospinal fluid (CSF) markers of vascular injury and neuroinflammation with AD biomarkers in middle‐aged Black/African American (B/AA) and non‐Hispanic White (NHW) participants.METHODSAdults (45–65 years) with a parental history of AD were enrolled (n = 82). CSF and blood biomarkers were collected at baseline and year 2.RESULTSCSF total tau (t‐tau), phosphorylated tau (p‐tau), and amyloid beta (Aβ)40 were elevated at year 2 compared to baseline. CSF soluble platelet‐derived growth factor receptor β (sPDGFRβ) levels, a marker of pericyte injury, correlated positively with t‐tau, p‐tau, Aβ40 markers of vascular injury, and cytokines at baseline and year 2. CSF sPDGFRβ and tau were significantly lower in B/AA than NHW.DISCUSSIONVascular dysfunction and neuroinflammation may precede cognitive decline and disease pathology in the very early preclinical stages of AD, and there are race‐related differences in these relationships.Highlights
Cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers changed over 2 years in high‐risk middle‐aged adults.
Markers of vascular dysfunction were associated with the CSF biomarkers amyloid beta and tau.
AD biomarkers were lower in Black compared to non‐Hispanic White individuals.
Markers of vascular dysfunction were lower among Black individuals.
Artwork in anatomy education: A way to improve undergraduate students' self‐efficacy and attitude
Authors: HadaviBavili Parisa , İlçioğlu Kevser 
Published: November 2023

AbstractAnatomy is one of the leading subjects in health science, and students need a strong anatomy background in these fields. Traditional lecturer‐oriented anatomy education is based predominantly on passive learning methods. In recent years, alternative educational methods like hands‐on art and 3D atlas‐based education methods have become more popular as competitive alternatives to traditional approaches. This is a prospective, randomized, longitudinal, interventional study, and a total of 181 undergraduate students participated in this study. A comparative design was used with two groups: Artwork and Atlas. This study aims to evaluate the effectiveness of creative and artistic approaches in improving undergraduate students' attitudes and self‐efficacy toward anatomy courses. A Pearson correlation, an independent t‐test, and a paired t‐test were used to analyze the results. Both groups experienced a negative mean score on the anatomy self‐efficacy scale, suggesting an increase in anatomy self‐efficacy, and showed significant self‐efficacy improvements (p < 0.005). An independent t‐test analysis found no statistically significant difference between the Atlas group and the Artwork group on the anatomy self‐efficacy scales (pretest and posttest) and the anatomy attitudes scale (p > 0.005). Artwork‐based education and learning methods can be used as active learning methods to improve students' self‐efficacy toward anatomy. This method allows learners to employ their creative abilities in order to express their ideas visually, making complex concepts easier to comprehend. It can also help students develop practical, problem‐solving, critical thinking, and teamwork skills. It is cost‐effective and engaging since it does not need any expensive equipment.
Dissemination effect of data papers on scientific datasets
Authors: Jiao Hong , Qiu Yuhong , Ma Xiaowei , Yang Bo 
Published: November 2023

AbstractOpen data as an integral part of the open science movement enhances the openness and sharing of scientific datasets. Nevertheless, the normative utilization of data journals, data papers, scientific datasets, and data citations necessitates further research. This study aims to investigate the citation practices associated with data papers and to explore the role of data papers in disseminating scientific datasets. Dataset accession numbers from NCBI databases were employed to analyze the prevalence of data citations for data papers from PubMed Central. A dataset citation practice identification rule was subsequently established. The findings indicate a consistent growth in the number of biomedical data journals published in recent years, with data papers gaining attention and recognition as both publications and data sources. Although the use of data papers as citation sources for data remains relatively rare, there has been a steady increase in data paper citations for data utilization through formal data citations. Furthermore, the increasing proportion of datasets reported in data papers that are employed for analytical purposes highlights the distinct value of data papers in facilitating the dissemination and reuse of datasets to support novel research.
The effects of video feedback on running form
Authors: Morante Mariana , Miltenberger Raymond , Cook Jennifer 
Published: November 2023

AbstractCorrect running form is important for injury prevention; as such, correct form promotes continued engagement in running as a long‐term form of exercise. Researchers have shown video feedback to be an effective strategy to improve athletic form for a variety of sports, but it has not been evaluated in any behavior analytic research as a method for improving running form. The purpose of this study is to evaluate the effectiveness of video feedback to improve running form for regular runners. During baseline, each participant was video recorded while running without any feedback (verbal or video). During intervention, the researcher recorded the participant, then showed them the video and provided feedback on correct or incorrect form, according to a 9‐step task analysis. Results show that all three participants achieved 100% correct steps on the task analysis when video feedback was used to maintain their form during follow‐up.
Efficacy of spironolactone as adjunctive therapy to sodium valproate in bipolar‐I disorder: A double‐blind, randomized, placebo‐controlled clinical trial
Authors: Zandifar Atefeh , Badrfam Rahim , Gholamian Fatemeh , Shafiee Arman 
Published: November 2023

AbstractIntroductionTreatment of mood and cognitive symptoms of patients with bipolar disorder is associated with many complications and is generally not associated with therapeutic satisfaction. In this clinical trial, we evaluated the effectiveness of spironolactone in controlling mood and cognitive symptoms, sleep quality, appetite, and body mass index in patients with bipolar disorder in manic episodes.MethodsSixty inpatients with bipolar disorder in manic episodes were treated with spironolactone/placebo in an 8‐week randomized, double‐blind, placebo‐controlled clinical trial. They were evaluated using the Young Mania Rating Scale (YMRS), mini‐mental state examination (MMSE), Pittsburgh sleep quality index, Simplified Nutritional Appetite Questionnaire, and body mass index in weeks 1, 4, and 8.ResultsFor cognitive impairment (MMSE), there were significant interaction effects of group and time at week 8 (B = −1.60, SE = 0.69, t = −2.33, p = .021) such that individuals in the spironolactone group experienced more improvement in their cognitive performance. For manic symptoms (YMRS), there were no significant interaction effects of group and time at week 8 (B = −2.53, SE = 1.46, t = −1.73, p = .085).ConclusionsConsidering the promising findings in this clinical trial, further study of spironolactone as adjunctive therapy in bipolar disorder in manic episodes with larger sample sizes, multicenter settings, and longer follow‐ups are recommended.
Can environmental non‐government organizations promote firms' environmental innovation? The role of environmental regulation and informatization level
Authors: Liao Zhongju , Zhang Mengnan 
Published: November 2023

AbstractEnvironmental non‐governmental organizations (ENGOs), as important civil society organizations in the environmental arena, play a role in promoting firms' environmental behavior. Based on institutional theory, this study constructed a relationship model among environmental ENGOs, environmental regulation, informatization level, and environmental innovation. Using data from 31 provinces in China from 2010 to 2021 as research samples, this study investigated the impact of ENGOs on firms' environmental innovation, as well as the mediating role of environmental regulation and the moderating role of the informatization level. The results showed that ENGOs had a positive effect on firms' environmental innovation, and the informatization level negatively moderated the impact of ENGOs on firms' environmental innovation, but environmental regulation did not play a mediating role in the relationship between ENGOs and firms' environmental innovation. Based on the conclusions, this study suggests leveraging the role of ENGOs, strengthening the power of environmental regulation, and improving the informatization level to drive firms' environmental innovation.
Four New Terpyridine Complexes Based Polyoxometalates with [W10O32]4– Anions as High‐Efficiency Dual‐Site Catalysis for Thioether Oxidation Reaction†
Authors: Zhang Yin , Yu Wei‐Dong , Wang Fang‐Qian , Wang Xiangnan , Zhou Jiawan , Liu Chao , Yan Jun 
Published: November 2023

Comprehensive SummaryPolyoxometalates modified with complex cations have attracted increasing attention because of the fascinating properties and the controllable structures. By adjusting the synthesis conditions, four new terpyridine complexes based hybrid POMs, [(TPY‐H)CuCl]4 [W10O32]·2DMF·2H2O (1), [(TPY‐H)Cu(DMSO)(H2O)]2[W10O32]·2H2O (2), [(TPY‐H)2Cu]2[W10O32]·6DMSO·8H2O (3) and [(TPY‐Br)CuCl (DMSO)(H2O)]2[(TPY‐Br)CuCl]2[W10O32]·2DMSO·4H2O (4), were prepared by using ‘one‐pot’ method. Sing‐crystal X‐ray diffraction analyses, infrared radiation, etc., revealed the structural composition of compounds 1—4, which indicates that synthesis conditions have a directional regulatory effect on the compounds synthesis. Thioether oxidation catalytic reactions show 1—4 have good catalytic activities, and powder X‐ray diffraction and thermogravimetry analysis show 1—4 have superduper catalytic stability. Moreover, 4 has better catalytic activity because of the different structure of terpyridine complexes. Therefore, a possible mechanism of dual‐site catalysis by both cations and anions is proposed.
Heterostructured flower‐like NiO/Co3O4 microspheres modified by bifunctional carbon quantum dots as a battery‐type cathode for high energy and power density hybrid supercapacitors
Authors: Liu Xinru , Zhu Yirong , Lu Zhihui , Xiao Jin , Zou Guoqiang , Hou Hongshuai , Ji Xiaobo 
Published: November 2023

AbstractHybrid supercapacitors (HSCs) comprising a battery‐type cathode and capacitive anode have recently become a research hotspot. Nevertheless, the low capacity utilization, poor kinetic behavior, and unstable structure of a single battery‐type oxide cathode restrict the overall performance of the device. Herein, the carbon quantum dots (CQDs) modified NiO/Co3O4 heterostructured flower‐like microspheres are constructed, and enhanced specific capacity, rate capability, and cycling performance are achieved when used as the cathode for HSCs. This is attributed to the fact that the modification of bifunctional CQDs as size regulators and conductive agents and the construction of heterostructure can not only improve the specific surface area and provide more electroactive sites, thereby enhancing the charge storage performance but also regulate the electronic structure and boost the interface charge transfer capability and electronic conductivity, thereby boosting the reaction kinetics and cycle stability. The enhanced electrochemical kinetic behavior is revealed by electrochemical kinetic analyses based on cyclic voltammetry, electrochemical impedance spectroscopy tests and density functional theory calculations. Meanwhile, the electrochemical reaction process and energy storage mechanism are illustrated by ex‐situ X‐ray diffraction and X‐ray photoelectron spectroscopy characterizations. Furthermore, an HSC is further constructed using the CQDs/NiO/Co3O4 heterostructured flower‐like microspheres as the cathode, simultaneously achieving high energy density (40.9 Wh kg−1), high power density (24 kW kg−1), and splendid cyclic stability (94.2% capacity retention after 5000 cycles at 10 A g−1). These synergistic modification strategies of bifunctional CQDs modification and heterostructure design provide a valuable direction for the design and development of HSCs with both high energy density and high power density.
Utilizing Gelatin Waste for Efficient Bimodal Porous Silica Adsorbents for Carbon Dioxide Capture
Authors: Numpilai Thanapha , Witoon Thongthai 
Published: November 2023

AbstractThis study explores the modification of pore structures in porous silica materials synthesized using sodium silicate and waste gelatin, under varying silica‐to‐gelatin ratios. At ratios of 1.0–1.5, bimodal porous silica with mesopores and macropores emerged due to spaces between silica nanoparticles and clusters, following gelatin elimination. The study further evaluated the obtained bimodal porous silica as polyethyleneimine (PEI) supports for CO2 capture, alongside PEI‐loaded unimodal porous silica and hollow silica sphere for comparison. Notably, the PEI‐loaded bimodal silica showcased superior CO2 uptake, achieving 145.6 mg g−1 at 90 °C. Transmission electron microscopy (TEM) revealed PEI′s uniform distribution within the pores of bimodal silica, unlike the excessive surface layering seen in unimodal silica. Conversely, PEI completely filled the hollow porous silica‘s interior, extending gas molecule diffusion distance. All sorbents displayed nearly constant CO2 adsorption across 20 cycles, demonstrating outstanding stability. Notably, the bimodal porous silica displayed a negligible capacity loss, underscoring its robust performance.
Heteronuclear Gold(I)‐Copper(I) Complexes with Thia‐ and Mixed Thia‐Aza Macrocyclic Ligands: Synthesis, Structures and Optical Properties
Authors: Donamaría Rocío , Lippolis Vito , López‐de‐Luzuriaga José M. , Monge Miguel , Olmos M. Elena 
Published: November 2023

AbstractThe reactivity of the heterometallic polynuclear complexes [{Au(R)2}2Cu2(MeCN)2]n (R=C6F5, C6Cl5) with the thioether crowns 1,4,7‐trithiacyclononane (L1, [12]aneS3), 1,4,8,11‐tetrathiacyclododecane (L2, [14]aneS4), 1,4,7,10,13,16,19,22‐octathiacyclotetracosane (L3, [24]aneS8), and the quinoline functionalized pendant arm derivatives of the 12‐membered mixed‐donor macrocycles 1‐aza‐,4,7,10‐trithiacyclododecane ([12]aneNS3) and 1,7‐diaza‐4,10‐dithiacyclododecane ([12]aneN2S2), L4 and L5, respectively, was investigated in THF solution. While with L4 and L5 only ionic compounds of general formulation [Cu(L)][Au(R)2] were isolated and structurally characterized (none of them featuring Au⋅⋅⋅Cu interactions), with L1‐L3, beside similar ionic compounds, some heteronuclear complexes of general formulation [{Au(R)2}{Cu(L)}] and featuring Au⋅⋅⋅Cu interactions were also obtained. All of them display rather unusual non‐classical C−H⋅⋅⋅Au hydrogen interactions. The complexes display in the solid state different optical properties related to their structures, which have been studied experimentally and theoretically via TD‐DFT calculations. In particular, all compounds of the type [{Au(R)2}{Cu(L)}] featuring Au⋅⋅⋅Cu metallophilic interactions display luminescence in the solid state both at room temperature (RT) and at 77 K. On the contrary, ionic compounds of general formulation [Cu(L)][Au(R)2], except [Cu(L4)][Au(C6F5)2], are not luminescent.
SETD2 deficiency promotes renal fibrosis through the TGF‐β/Smad signalling pathway in the absence of VHL
Authors: Liu Changwei , Ni Li , Li Xiaoxue , Rao Hanyu , Feng Wenxin , Zhu Yiwen , Zhang Wei , Ma Chunxiao , Xu Yue , Gui Liming , Wang Ziyi , Aji Rebiguli , Xu Jin , Gao Wei‐Qiang , Li Li 
Published: November 2023

AbstractBackgroundRenal fibrosis is the final development pathway and the most common pathological manifestation of chronic kidney disease. Epigenetic alteration is a significant intrinsic factor contributing to the development of renal fibrosis. SET domain‐containing 2 (SETD2) is the sole histone H3K36 trimethyltransferase, catalysing H3K36 trimethylation. There is evidence that SETD2‐mediated epigenetic alterations are implicated in many diseases. However, it is unclear what role SETD2 plays in the development of renal fibrosis.MethodsKidney tissues from mice as well as HK2 cells were used as research subjects. Clinical databases of patients with renal fibrosis were analysed to investigate whether SETD2 expression is reduced in the occurrence of renal fibrosis. SETD2 and Von Hippel–Lindau (VHL) double‐knockout mice were used to further investigate the role of SETD2 in renal fibrosis. Renal tubular epithelial cells isolated from mice were used for RNA sequencing and chromatin immunoprecipitation sequencing to search for molecular signalling pathways and key molecules leading to renal fibrosis in mice. Molecular and cell biology experiments were conducted to analyse and validate the role of SETD2 in the development of renal fibrosis. Finally, rescue experiments were performed to determine the molecular mechanism of SETD2 deficiency in the development of renal fibrosis.ResultsSETD2 deficiency leads to severe renal fibrosis in VHL‐deficient mice. Mechanically, SETD2 maintains the transcriptional level of Smad7, a negative feedback factor of the transforming growth factor‐β (TGF‐β)/Smad signalling pathway, thereby preventing the activation of the TGF‐β/Smad signalling pathway. Deletion of SETD2 leads to reduced Smad7 expression, which results in activation of the TGF‐β/Smad signalling pathway and ultimately renal fibrosis in the absence of VHL.ConclusionsOur findings reveal the role of SETD2‐mediated H3K36me3 of Smad7 in regulating the TGF‐β/Smad signalling pathway in renal fibrogenesis and provide an innovative insight into SETD2 as a potential therapeutic target for the treatment of renal fibrosis.