bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of the effect of topical application of N-acetylcysteine on the recovery rate of patients with chronic rhinosinusitis after surgical treatment, based on SNOT-22 test scores
Authors: Falko Anton , Naumenko Oleksandr 
Published: October 2023

endonasal endoscopic sinus surgery ( FESS ) is the gold standard for the treatment of patients with chronic rhinosinusitis worldwide. The task of the otorhinolaryngologist is aimed at restoring the function of the osteomyetal complex . However, the tactics of the postoperative period, especially the topical form of treatment, remain an extremely important issue. The purpose of the study: Determination of the influence of the topical form of N-acetylcysteine on the speed of recovery of patients after FESS, compared to standardized topical treatment, based on the sino-nasal outcome test. The study was carried out at the Department of Otorhinolaryngology of Bogomolets National Medical University on the basis of the Oleksandriv Clinical Hospital of Kyiv together with the CNME "Kremenchuk City Hospital of Planned Treatment", Kremenchuk. A population of 96 patients aged 18 to 60 with a diagnosis of chronic rhinosinusitis after surgical treatment. The randomization method was two groups of patients were formed. 1st group (study) - 47 patients who received irrigation of the topical form of N-acetylcysteine. 2nd group (control) - 49 patients who received topical therapy using irrigation of 0.9% NaCl solution. The volume of surgical intervention of both groups of the study: Endonasal endoscopic maxillotomy, septoplasty , bilateral vasotomy of the lower nasal turbinates. To participate in the study, all participants had to sign an informed consent. All patients were surveyed using the SNOT22 test on the 1st day before surgery treatment and on the 3rd, 10th and 28th days after surgical treatment.According to the obtained results, the effectiveness of both methods of topical treatment was revealed (p=0.001). However, the use of topical N -acetylcysteine in patients of the study group has more effective dynamics of symptoms, according to the SNOT -22 questionnaire on the 3rd (p=0.034), 10th (p=0.002) and 28th day (p=0.001) after surgical treatment. Therefore, the topical form of N-acetylcysteine has an effective effect on the speed of recovery of the mucous membrane of the nasal cavity and paranasal sinuses and improves the quality of life in patients with chronic rhinosinusitis after FESS.
Hearing and speech outcomes in children with cochlear nerve hypoplasia who underwent cochlear implantation
Authors: Pratamisiwi Rindy Yunita , Zizlavsky Semiramis , Priyono Harim , Suroyo Indrati , Handryastuti Setyo , Prihartono Joedo 
Published: October 2023

Background: Data on hearing and speech outcomes following cochlear implantation in prelingual sensorineural hearing loss (SNHL) children with cochlear nerve hypoplasia, especially in Indonesia, is still limited. Purpose: To evaluate the hearing and speech function of prelingual SNHL children who had undergone cochlear implantation. Method: A retrospective cross-sectional study was conducted on 28 children who had undergone cochlear implantation procedures at the Department of Otorhinolaryngology and Head and Neck Surgery, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, for more than 12 months. The hearing and speech function of the subjects were assessed using the modified Categories of Auditory Performance (CAP-II) and the speech intelligibility rating (SIR) scores. Result: Children with cochlear nerve hypoplasia showed an increase in CAP-II and SIR scores after using cochlear implants for more than 12 months (versus pre-surgery, high CAP score [≥5]: 89.3% [25/28 children] vs 3.6% [1/28 children] and high SIR score [≥3]: 82.1% [23/28 children] vs 7.1% [2/28 children]; both p<0.001). Post-operative CAP-II and post-operative SIR scores were highly positively correlated (r=0.705, p<0.001). Type of cochlear nerve hypoplasia (unilateral vs bilateral) were not significantly associated with post-operative CAP-II and SIR scores (p=0.382 and p=0.459, respectively). Conclusion: Prelingual SNHL children with cochlear nerve hypoplasia may still get the benefit from cochlear implantation, as shown by a remarkable improvement in hearing and speech function as assessed with the CAP-II and SIR scores.
Keywords: auditory perception, cochlear implants, cochlear nerve hypoplasia, prelingual sensorineural hearing loss, speech intelligibility
Shifting Mindsets: An Advocacy Coalition Framework Analysis of Canadian Federal Housing Policy
Authors: Rain Justin , Hudson Graham 
Published: October 2023

<p>Thousands of people across Canada are struggling to find affordable and adequate housing. The following study is an analysis of housing policy in Canada, in order to shed light on its past shortcomings. After applying the advocacy coalition framework, I will demonstrate how the federal government has historically divided into two main coalitions when it comes to addressing inadequate housing in Canada; the market housing coalition and the social housing coalition. By implementing a process tracing methodological approach, I will examine the effects of past housing policy and how it has led to present-day legislation. I will conclude that Prime Minister Justin Trudeau has promised housing advancements and through incremental changes, he has established, for the first time ever in Canada, the right to housing. </p>
Територіальна оборона в перспективній моделі оборони України
Authors: Собко С. С. , Пунда Ю. В. , Музиченко Д. П. 
Published: October 2023

У статті наведені деякі результати аналізу створення і застосування Сил територіальної оборони Збройних Сил України та прогноз можливих ролі й місця новоствореного роду сил у перспективній моделі оборони України. Сучасні тенденції у воєнному мистецтві – війна знов стає всеосяжною, тотальною – вимагають переглянути роль територіальної оборони: Сили територіальної оборони Збройних Сил України повинні бути не допоміжною силою, а однією з важливих складових Сил оборони України.
Запропоновано концепцію дій військових формувань Сил територіальної оборони Збройних Сил України та добровольчих формувань територіальних громад, а також бачення ролі Сил територіальної оборони в перспективній моделі оборони України.
Стратегічні комунікації України в умовах російсько-української війни
Authors: Іжутова І. В. 
Published: October 2023

У статті викладені уроки розвитку стратегічних комунікацій в Україні з 2014 р. як ефективної відповіді на пропаганду та дезінформацію та як інструменту поширення і підтримки власного наративу та ключових повідомлень з метою досягнення стратегічних цілей.
Основна увага статті зосереджена на періоді після 24 лютого 2023 р. – після повномасштабного вторгнення. Український досвід є унікальним і його добре вивчають у всьому світі. Повномасштабне вторгнення 2022 р. довело важливість стратегічних комунікацій. Український досвід не схожий на будь-яку іншу країну, з помилками і досягненнями, із залученням усіх рівнів комунікацій, а також елементів стратегічних комунікацій. По суті, це практична демонстрація інтеграції стратегічних комунікацій і військових операцій.
Pyogenic Granuloma of Inferior Turbinate in Children: Common Symptoms with a Rare Diagnosis
Authors: HASSAN NOR EYZAWIAH , ARIFF SITI NUR FARHANA , HITAM SHAHRUL , SALAHUDDIN NOR AZIRAH , AREPEN SITI ASMAT 
Published: October 2023

Pyogenic granuloma (PG) is a rapidly growing benign lesion of the skin and mucous membrane. Its etiology is still unclear. It is suggested to have arisen either due to trauma or hormonal influences. Pyogenic granuloma is regularly found in the oral cavity. Even though it is rare, it does occur in the nasal cavity and a few cases of pyogenic granuloma have been reported among the paediatric population. We present a case of a 6-year-old boy, who presented with unilateral nasal blockage and recurrent epistaxis. The child has a history of allergic rhinitis and frequent nasal picking. Clinical examination revealed a small broad based reddish mass at the anterior part of the right inferior turbinate. The histopathological examination from complete excisional biopsy was consistent with pyogenic granuloma. Although pyogenic granuloma is relatively rare, we should raise suspicion in young patients who complain of progressive unilateral nasal blockage and recurrent epistaxis, with or without a history of trauma. Thorough clinical examination is adequate in small lesion thus sparing the need for radiological investigation for bigger and extensive lesions. Complete excision is the ultimate treatment to avoid recurrence.
Cost-effectiveness analysis of abemaciclib with endocrine therapy (ET) versus ET alone for HR+, HER2−, node-positive, high-risk early breast cancer in Italy
Authors: Davie Alison , Traoré Sory , Giovannitti Massimo , Pompilio Giuseppe , Lambton Mark , Cakar Esra , Chatterjee Anuja 
Published: October 2023

Background: Abemaciclib was recently approved by the European Medicines Agency in combination with adjuvant endocrine therapy (ET) for adult patients with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2−), node-positive early breast cancer (EBC) at high risk of recurrence.
Objective: To evaluate the cost-effectiveness of abemaciclib plus ET vs. ET alone in patients with HR+, HER2−, node-positive EBC at high risk of disease recurrence, from the Italian healthcare system perspective.
Methods: A cohort state transition model was developed with five states: invasive disease-free survival (IDFS), nonmetastatic recurrence, remission, metastatic recurrence, and death. The analysis had a time horizon of 30 years. Individual patient-level data from the monarchE trial (NCT03155997) were used to generate IDFS estimates. Resource use included drug acquisition/administration, best supportive care, terminal care, adverse events, hospitalization, post-progression therapy, and associated resource use in the metastatic disease health state. Health state utilities were derived from monarchE patient-level data and other sources, applying Italian tariffs where feasible.
Results: The estimated total discounted costs (€39,249 vs. €16,806; difference: €22,443) and quality-adjusted life years (QALYs) (11.49 vs. 10.50; difference: 0.99) were higher for abemaciclib plus ET compared with ET alone. The incremental cost-effectiveness ratio was €22,651 per QALY gained. The likelihood of abemaciclib plus ET being cost-effective vs. ET alone was 99% at a willingness-to-pay threshold of €30,000 per QALY gained.
Conclusion: Abemaciclib plus ET is a cost-effective treatment option vs. ET alone for those with HR+, HER2− node-positive EBC at high risk of recurrence in Italy.
Globális ellátási láncok aktuális kihívásai
Authors: Király Éva , Hegedűs Ferenc , Domboróczky Zoltán 
Published: October 2023

A közelmúlt környezeti-, társadalmi- és gazdasági változásai ráirányították a figyelmet a globális ellátási láncok sérülékenységére. Különösen azokban az esetekben igaz ez, amikor a külső befolyásoló tényezők válságszerűek, hiszen a válságok – természetükből adódóan – újszerű kezelést, megoldást kívánnak. Az ellátási lánc menedzsment tudományterülete jelenleg éppen olyan periódusban van, amikor ezeket az újszerű megoldásokat szükséges felszínre hozni, hiszen a korábbi gyakorlatok már nem feltétlenül képesek szavatolni az ellátási láncok szakadásmentes és kiszámítható működését a megváltozott feltételrendszerben. Tanulmányunkban összefoglaljuk a közelmúlt azon traumáit, amelyek közvetlen vagy közvetett hatást gyakoroltak a globális ellátási láncokra. E tekintetben nem a közvetlen vagy közvetett jellemzőre koncentráltunk, hanem az ellátási láncokra gyakorolt hatás mértékére. A globális befolyásoló hatások számbavételén túl vizsgáljuk az egyes jelenségek logisztikai, ellátási lánc szervezési következményeit, melyek okán várhatóan számos vállalat átalakítja üzleti modelljét. Tanulmányunkban a szcenárió-elemzés módszertanát alkalmazva megfogalmazzuk az átalakulás lehetséges jövőbeli dimenzióit, szem előtt tartva ezek gyakorlati alkalmazhatóságát, hiszen olyan kihívásokra igyekeznek választ adni, melyekkel a közeljövőben a vállalatoknak szembesülni kell ellátási láncaik megszervezése és működtetése során.
HORREUR COSMIQUE ET L’EXTÉRIORITÉ RADICALE
Authors: Menon Junior Walter 
Published: October 2023

Ce texte prêtent rend compte de la notion d’ontologie élaborée à partir de la lecture de l’œuvre de H. P. Lovecraft par Fabián Ludueña Romandini. Le philosophe argentin prend le texte lovecraftien en tant que le développement d’une ontologie, dont l’aspect fictionnel est entendu comme la procédure spéculative qui produit une cosmologie et une mythologie. Cette ontologie parle de ce qui est hors de tout mode d’existence et donc de ce qu’on appellerait d’extériorité radicale, de laquelle on ne peut connaitre que ce qu’on représente fictionnellement à partir des rêves, des transes mystiques ou des délires et hallucinations. Dans ce sens, l’extériorité radicale présuppose une ontologie sans catégories possibles. Une autre lecture de l’œuvre lovecraftienne est possible cependant : l’extériorité radicale n’est qu’autre dénomination de la différence incarnée dans le primitif, dont la représentation n’est que l’incorporel, ou le corp non individualisé, déformé de l’immigrant qu’incarne, pour HPL, la dégénération biologique et sociale.
Mots clés : Lovecraft ; extériorité radicale ; Romandini ; cosmologie ; politique.
Body mass index, neck circumference, and hypertension: a prospective cohort study
Authors: Ren Tao-jun , Zhang Kun , Li Wen-juan , Ren Shu-tang , Huang Yun-zhou , Yang Ning , Wu Shou-ling , Li Yu-ming 
Published: October 2023

ObjectiveThis study aimed to investigate the association between BMI combined with neck circumference and the risk of hypertension.MethodsWe selected participants from the Kailuan study in 2014 who were normotensive as our research subjects. We compared the risk of hypertension among individuals in group 1 (non-obese with low neck circumference), group 2 (non-obese with high neck circumference), group 3 (obese with low neck circumference), and group 4 (obese with high neck circumference).ResultsAfter a median observation period of 3.86 years, hypertension occurred in 13,383 participants. Subjects in Group 2, 3, and 4 had significantly higher risks of hypertension compared to Group 1, with hazard ratios (HRs) of 1.066 (95% CI: 1.025, 1.110), 1.322 (95% CI: 1.235, 1.415), and 1.422 (95% CI: 1.337, 1.512), respectively. Additionally, adding BMI to a conventional model had a greater incremental effect on predicting hypertension compared to adding neck circumference alone. However, considering both BMI and neck circumference together further improved the prediction of hypertension.ConclusionIndividuals with both high BMI and high neck circumference face a higher risk of hypertension. Moreover, BMI is a superior predictor of hypertension risk compared to neck circumference, but using both of these measures can further enhance the accuracy of hypertension risk prediction.
Fluid-mineral dynamics at the Rincón de la Vieja volcano—hydrothermal system (Costa Rica) inferred by the study of major, minor and rare earth elements in the hyperacid crater lake
Authors: Pappaterra Sabrina , Inguaggiato Claudio , Rouwet Dmitri , Levresse Gilles , Peiffer Loic , Apollaro Carmine , Mora-Amador Raúl , Ramírez-Umaña Carlos , González Gino , Schiavo Benedetto , Kretzschmar Thomas Gunter , Brusca Lorenzo 
Published: October 2023

Volcanic lakes are complex natural systems and their chemical composition is related to a myriad of processes. The chemical composition of major, minor, Rare Earth Elements (REE) and physico-chemical parameters at the hyperacid crater lake of Rincón de la Vieja volcano (Costa Rica) are here investigated during February 2013–August 2014. The study of the lake chemical composition allows to identify the main geochemical processes occurring in the lake and to track the changes in the volcanic activity, both important for active volcanoes monitoring. The total REE concentration (∑REE) dissolved in the crater lake varies from 2.7 to 3.6 mg kg−1 during the period of observation. REE in the water lake samples normalized to the average volcanic local rock (REEN-local rock) are depleted in light REE (LREE). On the contrary REEN-local rock in the solids precipitated (mainly gypsum/anhydrite), from lake water samples in laboratory at 22°C, are enriched in LREE. The low variability of (La/Pr)N-local rock and (LREE/HREE)N-local rock ratios (0.92–1.07 and 0.66–0.81, respectively) in crater lake waters is consistent with the low phreatic activity (less than 10 phreatic eruptions in 2 years) observed during the period of observation. This period of low activity precedes the unrest started in 2015, thus, it could be considered as a pre-unrest, characterized by infrequent phreatic eruptions. No clear changes in the REE chemistry are associated with the phreatic eruption occurred at mid-2013. The results obtained investigating water-rock interaction processes at the Rincón de la Vieja crater lake show that rock dissolution and mineral precipitation/dissolution are the main processes that control the variability of cations composition over time. In particular, precipitation and dissolution of gypsum and alunite are responsible for the variations of REE in the waters. Despite the low variations of (La/Pr)N-local rock and (LREE/HREE)N-local rock ratios, this study allows to suggest that REE can be used, together with major elements, as practical tracers of water-rock interaction processes and mineral precipitation/dissolution at active hyperacid crater lakes over time, also during periods of quiescence and low phreatic activity.
A systematic review and meta-analysis: clinical outcomes of recurrent pregnancy failure resulting from preimplantation genetic testing for aneuploidy
Authors: Liang Zhuo , Wen Qiuyue , Li Jingjing , Zeng Dingyuan , Huang Pinxiu 
Published: October 2023

BackgroundPreimplantation genetic testing for aneuploidy (PGT-A) is an emerging technology that aims to identify euploid embryos for transfer, reducing the risk of embryonic chromosomal abnormalities. However, the clinical benefits of PGT-A in recurrent pregnancy failure (RPF) patients, particularly in young RPF patients, remains uncertain.Objective and rationaleThis meta-analysis aimed to determine whether RPF patients undergoing PGT-A had better clinical outcomes compared to those not undergoing PGT-A, thus assessing the value of PGT-A in clinical practice.Search methodsWe systematically searched PubMed, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP Database for Chinese Technical Periodicals (VIP) from 2002 to 2022. Thirteen published studies involving 930 RPF patients screened using PGT-A and over 1,434 RPF patients screened without PGT-A were included in this meta-analysis. Clinical outcomes were evaluated based on embryo transfers after PGT-A (n=1,015) and without PGT-A (n=1,799).Clinical outcomesThe PGT-A group demonstrated superior clinical outcomes compared to the in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) group. The PGT-A group had a significantly higher implantation rate (IR) (RR=2.01, 95% CI: [1.73; 2.34]), clinical pregnancy rate (CPR) (RR=1.53, 95% CI: [1.36; 1.71]), ongoing pregnancy rate (OPR) (RR=1.76, 95% CI: [1.35; 2.29]), live birth rate (LBR) (RR=1.75, 95% CI: [1.51; 2.03]), and significantly lower clinical miscarriage rate (CMR) (RR=0.74, 95% CI: [0.54; 0.99]). Subgroup analysis based on patient age (under 35 years and 35 years or older) showed that both PGT-A subgroups had significantly better CPR (P&lt;0.01) and LBR (P&lt;0.05) values compared to the IVF/ICSI groups.SummaryThis meta-analysis demonstrates that PGT-A in RPF patients, is associated with improved clinical outcomes, including higher IR, CPR, OPR, and LBR values, and lower CMR compared to the IVF/ICSI group. These findings support the positive clinical application of PGT-A in RPF patients.Systematic Review Registrationhttp://INPLASY.com, identifier INPLASY 202320118.
The effect of growth hormone on ovarian function recovery in a mouse model of ovarian insufficiency
Authors: Kim Su Mi , Yoo Jung Young , Hong Yeon Hee , Lee Jaewang , Kim Ji Hyang , Lee Jung Ryeol 
Published: October 2023

ObjectivesTo evaluate the effects and mechanisms of action of growth hormone (GH) in the recovery of ovarian function in ovarian insufficiency induced by cyclophosphamide (CP) in a mouse model.Materials and methodsAfter inducing ovarian insufficiency by administering 400 mg/kg of CP intraperitoneally to 6-week-old ICR mice, the mice were divided into four groups (control, CP, 1 mg/kg GH, and 2 mg/kg GH) with 10 mice in each group. GH was administered a week later for 7 days. Five mice from each group were sacrificed the next day, and their ovaries were collected for histological examination. The remaining mice were superovulated for in vitro fertilization (IVF). The terminal deoxynucleotidyl transferase dUTP-nick end labeling assay was performed to detect apoptosis. Masson’s trichrome staining was used to analyze the degree of fibrosis. To quantify angiogenesis, CD31 immunohistochemistry was performed. Angiogenesis-related gene expression profiles were assessed using quantitative reverse transcription polymerase chain reaction.ResultsCP induced the loss of non-growing (primordial and primary) follicles while GH significantly protected primordial follicles and increased follicular quality. The CP group showed a decrease in fertilization and blastocyst formation rates in IVF. In contrast, the GH treatment group showed dose-dependent enhanced IVF outcomes. Furthermore, GH treatment decreased apoptosis and stromal fibrosis and increased angiogenesis. Many genes involved in angiogenesis, especially Leptin (Lep), platelet endothelial cell adhesion molecule 1 (Pecam-1), and angiogenin (Ang) were up-regulated in the GH treatment groups.ConclusionGH treatment may promote the recovery of ovarian function in ovarian insufficiency induced by the administration of CP via decreasing apoptosis and stromal fibrosis and upregulating Lep, Pecam-1, and Ang genes.