bluuebunny/crossref_metadata_2025_split huggingface dataset:
The satisfaction of clients and caregivers with telehealth speech-language pathology services
Authors: Alyahya Reem S. W. 
Published: February 2025

Objectives To investigate the satisfaction of service users with different aspects related to telehealth speech-language pathology (SLP) services, and examine the influence of client's demographics, medical diagnosis, and type of clinical services on the level of satisfaction with telehealth services. Methods A questionnaire was developed and validated to measure the satisfaction of clients and caregivers with telehealth services. Phone survey was used to collect data from clients and caregivers of clients who received telehealth SLP services. Results 302 clients and caregivers completed the survey. Most of the respondents were strongly satisfied with different aspects related to telehealth, including their whole telehealth experience (82.12%), the perceived benefits from telehealth (69.21%), and the perceived quality of healthcare received through telehealth (87.75%). The levels of satisfaction with these aspects were not related to age or gender, but they were significantly influenced by the SLP diagnosis ( p < 0.001). The results also showed high levels of satisfaction across all types of clinical services, including screening, assessment, therapy, and monitoring. There were no significant relationships between the types of clinical services and the levels of satisfaction with telehealth. Conclusions Most clients and caregivers were satisfied with SLP services received via telehealth irrespective of the type of clinical service, client's age, or gender. However, satisfaction with SLP telehealth and patient experience varied according to the client's diagnosis. These factors must be considered by policy makers and funding bodies while planning the implementation or expansion of telehealth SLP services.
Advanced Analytic and Pitch-Tracking Metrics Associated with UCL Surgery in Major League Baseball Pitchers: A Case-Control Study
Authors: Mastroianni Michael A. , Kunes Jennifer A. , El-Najjar Dany B. , Obana Kyle K. , Desai Sohil S. , Morrissette Cole R. , Alexander Frank J. , Rondon Alexander J. , Trofa David P. , Popkin Charles A. , Levine William N. , Ahmad Christopher S. 
Published: February 2025

Background: Ulnar collateral ligament (UCL) injury rates have been rising steadily, while the recent development of advanced analytics and pitch-tracking analysis now drives player development and evaluation throughout Major League Baseball (MLB). Purpose: To evaluate the association between several advanced analytic and pitch-tracking metrics on UCL surgery rates in MLB pitchers. Study Design: Case-control study. Methods: Included in this study were MLB pitchers who underwent primary UCL reconstruction or repair from April 2018 to November 2023. Exclusion criteria were pitchers without 2 qualifying seasons of preoperative pitch-tracking data and those who previously underwent UCL surgery. Uninjured matched controls were identified in a 2:1 ratio using season, age, position, handedness, and pitch count as covariates. Advanced analytics (eg, FanGraphs wins above replacement [fWAR], expected fielding-independent pitching [xFIP], physical pitch qualities [Stuff+] strike-zone command [Location+], and overall pitching ability [Pitching+]) and various pitch-tracking metrics used commonly in MLB player evaluation were collected from public web sources sponsored by MLB and used in previous studies. Statistical analysis consisted of unpaired t tests comparing cases and controls and binary logistic regression. Results: A total of 117 MLB pitchers who underwent primary UCL reconstruction or repair were compared with 234 matched controls. Cases had significantly superior pitch velocity, fWAR, xFIP, Pitching+, and Location+ compared with controls. There was no significant difference between cases and controls in pitch counts, spin, release points, release extension, approach angles, or overall pitch movement. Binary logistic regression identified velocity, Pitching+, and decreased fastball usage as being associated with UCL surgery ( P < .10 for all). Conclusion: In this analysis of several modern advanced analytic and pitch-tracking metrics, MLB pitchers who underwent UCL surgery threw harder with less fastball usage, and had superior overall pitching ability (Pitching+) and strike-zone command (Location+) than matched controls.
Insights into the nuclear-organelle DNA integration in Cicuta virosa (Apiaceae) provided by complete plastid and mitochondrial genomes
Authors: Park Seongjun , Hwang Yong , Kim Heesoo , Choi KyoungSu 
Published: February 2025

Abstract

Background
Gene transfer between the organelles and the nucleus plays a central role in shaping plant genome evolution. The identification and analysis of nuclear DNA of plastid (NUPTs) and mitochondrial (NUMTs) origins are important for exploring the extent of intracellular DNA transfer in genomes.

Results
We report the complete plastid and mitochondrial genomes (plastome and mitogenome) of Cicuta virosa (Apiaceae) as well as a draft nuclear genome using high-fidelity (HiFi) PacBio sequencing technologies. The C. virosa plastome (154,449 bp) is highly conserved, with a quadripartite structure, whereas the mitogenome (406,112 bp) exhibits two chromosomes (352,718 bp and 53,394 bp). The mitochondrial-encoded genes (rpl2, rps14, rps19, and sdh3) were successfully transferred to the nuclear genome. Our findings revealed extensive DNA transfer from organelles to the nucleus, with 6,686 NUPTs and 6,237 NUMTs detected, covering nearly the entire plastome (99.93%) and a substantial portion of the mitogenome (77.04%). These transfers exhibit a range of sequence identities (80–100%), suggesting multiple transfer events over evolutionary timescales. Recent DNA transfer between organelles and the nucleus is more frequent in mitochondria than that in plastids.

Conclusions
This study contributes to the understanding of ongoing genome evolution in C. virosa and underscores the significance of the organelle-nuclear genome interplay in plant species. Our findings provide valuable insights into the evolutionary processes that shape organelle genomes in Apiaceae, with implications for broader plant genome evolution.
Pathomorphological features of the proximal femur in crowe IV hips and their implication on stem selection during total hip arthroplasty
Authors: Gharanizadeh Kaveh , Mohammadyahya Elham , Bahaeddini Mohammad Reza , Amiri Shayan , Gravand Sajad Noori , Pezeshki Sepideh , Aminian Amir , Eslami Arvin , Tayyebi Hamed , Abolghasemian Mansour 
Published: February 2025

Abstract

Background
The best stem type and location for femoral shortening in high-riding developmental dysplasia of the hip (DDH) in not clear. We evaluated the morphology of the proximal femur on EOS™ images, focusing on the anatomical landmarks and measurements relevant to the stem selection in high-riding DDH. Our goal is to identify and define the differences in the anatomy of the proximal femur between patients with Crowe type IV DDH and normal individuals, in order to determine the appropriate neck cut location in these patients to increase the chances of successfully using a wedge femoral stem.

Methods
EOS™ images of 40 hips with Crowe type-IV DDH and 40 normal hips were included. The distances between the tip of the greater trochanter and vastus ridge (GT-VR), vastus ridge and proximal border of lesser trochanter (VR-LT), greater- and lesser trochanters (GT-LT), base width of the LT, and the proportion of these distances to the femoral length were evaluated. Canal Flare Index (CFI) was also measured, at two different levels.

Results
The mean GT-LT index was not different between the two groups (p = 0.46). The GT-VR index was smaller in the case group (p < 0.001), while the VR-LT index was greater (p < 0.001). The LT base width index was larger in the case group (P < 0.001). CFI was smaller at the LT level in dysplastic hips (P < 0.001), but the values were similar with a cut 1.5 cm above the LT (P = 0.67).

Conclusion
In Crowe IV hips, the GT height is shorter and the LT is located far more distally along the femoral metaphysis, resulting in a narrower canal width at the upper border of the lesser trochanter. Also, the CFI at the LT level is smaller, and to fit a wedge stem, the neck cut should be made at a higher level.
Rapid assessment of pre-service midwifery education in conflict settings: findings from a cross-sectional study in Nigeria and Somalia
Authors: Iwu Emilia , Elnakib Shatha , Abdullahi Hawa , Abimiku Rejoice Helma , Maina Charity , Mohamed Asia , Ayodeji Kazeem Olalekan , Odonye George , Sunday Rifkatu , Ahmed Maryan Abdulkadir , Omar Mohamed Ahmed , Dalmar Abdirisak A. , Grant Emilie , Tappis Hannah 
Published: February 2025

Abstract

Background
There is a dearth of evidence on the scale, scope and quality of midwifery education programs in conflict-affected settings. This study sought to assess the extent to which midwifery pre-service education programs meet national and global standards, and to explore how conflict affects pre-service midwifery education in Yobe State Nigeria and the Benadir and Galgaduud regions of Somalia.

Methods
A rapid assessment of midwifery education programs was conducted in the two midwifery education programs in Yobe State, Nigeria and in seven purposively selected programs in Somalia using an adaptation of the Midwifery Education Rapid Assessment Tool. Information was collected through interviews with program leadership, teachers, students, and clinical preceptors during school and clinical practice site visits. Researchers adapted the tool to reflect national and international standards, incorporating supplementary questions to capture considerations specific to conflict-affected contexts. Data were analyzed by program and country using Stata and Excel.

Results
In Nigeria, each school met 17 and 18 standards, respectively, out of 22 across assessment domains (77.3%–81.8%). In contrast, in Somalia, schools met between 6 and 10 standards out of the 18 standards for which data were available (33.3%–55.6%). The biggest gaps in Somalia were in leadership, infrastructure and resources. No schools in either setting had sufficient space or clinical practice sites that met International Confederation of Midwives (ICM) criteria, and only two were led by midwives. In Nigeria, all infrastructure, curriculum and student- and regulatory-related standards examined were met, but gaps were identified in program staffing and preceptor capacity, and support for faculty and clinical practice sites. In both countries, none of the programs met the average number of clinical practice experiences stipulated in the ICM guidelines due to a lack of teaching hospitals. Students in both countries felt safe on campus but did not feel safe traveling to and from the schools and clinical practice sites.

Conclusions
More investment in midwifery education is needed to ensure international standards for quality education are met. Proactive measures are needed to enhance student safety between school and practice settings in conflict-affected settings. By addressing these gaps, we can strive toward improving midwifery education.
Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy
Authors: Cai Yonghua , Xiao Heng , Xue Shuaishuai , Li Peng , Zhan Zhengming , Lin Jie , Song Zibin , Liu Jun , Xu Wei , Zhou Qixiong , Qi Songtao , Zhang Xi’an , Luo Ziyi 
Published: February 2025

Abstract

Background
Glioma, particularly glioblastoma (GBM), is a highly aggressive tumor with limited responsiveness to immunotherapy. PANoptosis, a form of programmed cell death merging pyroptosis, apoptosis, and necroptosis, plays an important role in reshaping the tumor microenvironment (TME) and enhancing immunotherapy effectiveness. This study investigates PANoptosis dynamics in glioma and explores the therapeutic potential of its activation, particularly through natural compounds such as cinobufagin.

Methods
We comprehensively analyzed PANoptosis-related genes (PANoRGs) in multiple glioma cohorts, identifying different PANoptosis patterns and constructing the PANoptosis enrichment score (PANoScore) to evaluate its relationship with patient prognosis and immune activity. Cinobufagin, identified as a PANoptosis activator, was evaluated for its ability to induce PANoptosis and enhance anti-tumor immune responses both in vitro and in vivo GBM models.

Results
Our findings indicate that high PANoScore gliomas showed increased immune cell infiltration, particularly effector T cells, and enhanced sensitivity to immunotherapies. Cinobufagin effectively induced PANoptosis, leading to increased immunogenic cell death, facilitated tumor-associated microglia/macrophages (TAMs) polarization towards an M1-like phenotype while augmenting CD4+/CD8 + T cell infiltration and activation. Importantly, cinobufagin combined with anti-PD-1 therapy exhibited significant synergistic effects and prolonged survival in GBM models.

Conclusions
These findings highlight the therapeutic potential of PANoptosis-targeting agents, such as cinobufagin, in combination with immunotherapy, offering a promising approach to convert “cold” tumors into “hot” ones and improving glioma treatment outcomes.
Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism
Authors: Wagner Lauren , Banchik Megan , Tsang Tawny , Okada Nana J. , Altshuler Rebecca , McDonald Nicole , Bookheimer Susan Y. , Jeste Shafali S. , Green Shulamite , Dapretto Mirella 
Published: February 2025

Abstract

Background
Language difficulties are common in autism spectrum disorder (ASD), a neurodevelopmental condition characterized by impairments in social communication as well as restricted and repetitive behaviors. Amongst infant siblings of children with an ASD diagnosis – who are at higher likelihood for developing ASD – a high proportion also show difficulties and delays in language acquisition.

Methods
In this study, we used functional magnetic resonance imaging (fMRI) to examine differences in language processing in 9-month-old infants at high (HL) and typical (TL) familial likelihood for ASD. Infants were presented with native (English) and novel (Japanese) speech while sleeping naturally in the scanner. Whole-brain and a priori region-of-interest analyses were conducted to evaluate neural differences in language processing based on likelihood group and language condition.

Results
HL infants showed attenuated responses to speech in general, particularly in left temporal language areas, as well as a lack of neural discrimination between the native and novel languages compared to the TL group. Importantly, we also demonstrate that HL infants show distinctly atypical patterns of lateralization for speech processing, particularly during native speech processing, suggesting a failure to left-lateralize. Limitations: The sample size, particularly for the TL group, is relatively modest because of the challenges inherent to collecting auditory stimulus-evoked data from sleeping participants, as well as retention and follow-up difficulties posed by the COVID-19 pandemic. The groups were not matched on some demographic variables, but the present findings held even after accounting for these differences.

Conclusions
To our knowledge, this is the first fMRI study to directly measure autism-associated atypicalities in native language uptake during infancy. These findings provide a better understanding of the neurodevelopmental underpinnings of language delay in ASD, which is a prerequisite step for developing earlier and more effective interventions for autistic children and HL siblings who experience language impairments.
Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women
Authors: Fleige Leonie , Capellino Silvia 
Published: February 2025

Abstract
Several studies report an impact of the neurotransmitter dopamine (DA) on human immune cells, with effects dependent on the immune cell type addressed and their activation status. Another contributing factor appears to be sex, as sex-specific differences in the dopaminergic pathway are described in the neurological context as well as in autoimmune diseases. However, a deeper understanding of these differences in peripheral immune cells remains limited. In this study, we investigated the effects of dopaminergic stimulation on activation and cytokine secretion of peripheral blood mononuclear cells from women and men using flow cytometry, ELISA, and multiplex assays. We found a B cell-driven downregulation in cytokine secretion of monocytes exclusively from women under physiological conditions in vitro. Moreover, B cells from men showed higher dopamine receptor (DR) expression, which was shown to be further increased by sex hormones only in men. In monocytes from women, an acute inflammatory stimulus via CpG combined with dopaminergic stimulation caused a switch to a proinflammatory phenotype, which was less pronounced in men. These novel findings in sex-specific responses to dopaminergic stimulation are crucial for understanding DA’s function in the healthy and activated immune system and provide evidence to treat DA-related pathologies in a sex-specific manner.
Gender and ethnoracial disparities in Veterans’ trauma exposure prevalence across differing life phases
Authors: Rossi Fernanda S. , Nillni Yael I. , Miller Alexandria N. , Fox Annie B. , Eliacin Johanne , Schnurr Paula P. , Duke Christopher C. , Gradus Jaimie L. , Galovski Tara E. 
Published: February 2025

Abstract

Background
Veterans show increased vulnerability to trauma exposure. Yet, there is limited research examining Veterans’ prevalence of experiencing different trauma exposure types by race, gender, and ethnicity and across unique phases of life (i.e., pre-military service, during service, and post-service). This study compares trauma exposure prevalence across women and men Veterans of differing ethnoracial identities (i.e., white, Black, Hispanic) within three life phases (i.e., pre-military service, during military service, post-military service).

Methods
This study examined survey data from 3,544 Veterans (1,781 women; 1,686 men) across six discrete data collection points (between August 2018 to March 2022). Surveys were mailed nationally and oversampled for women (51.6%) and Veterans living in high crime areas (67.6%). Veterans reported on their exposure to various trauma types (e.g., sexual assault, physical assault, community violence, captivity, serious accident, witnessing violent death) at each wave of data collection using items from a modified Life Events Checklist. Veterans also reported on demographic information (e.g., gender, race, ethnicity). Chi-square analyses were conducted to compare prevalence of reported exposure to each trauma type within each life phase across gender and ethnoracial groups.

Results
There were significant differences in trauma exposure prevalence across: (1) men vs. women Veterans; (2) white vs. Black vs. Hispanic Veterans; (3) Black vs. Hispanic vs. white women Veterans; and (4) Black vs. Hispanic, vs. white men Veterans. For example, in this study, Black men Veterans reported higher prevalence of intimate partner physical assault exposure pre-service (14.8%) and post-service (27.1%) than White men Veterans (9.0% and 13.8%; prevalence ratios = 1.64, 95% CI = 1.17, 2.32 and 1.96, 95% CI = 1.53, 2.51). White women Veterans were less likely to witness a violent death pre-service (11.5%) than Black (21.1%; prevalence ratio = 1.83, 95% CI = 1.42, 2.37) or Hispanic (18.1%) women Veterans.

Conclusions
Findings help uncover disparities within Veteran subgroups. They inform mental health treatment and prevention services to better meet the needs of all Veterans across differing life phases.
Medicolegal aspects of medical malpractice claims following aesthetic interventions in Cairo, Egypt
Authors: Rawash Ghada Abdelwahed , Ibrahim Neveen Adel , Farrag Islam Mostafa , Mostafa Somaya Youssef 
Published: February 2025

Abstract

Background
Medical malpractice presents a significant challenge to the healthcare system in Egypt and other countries, inflicting both physical and psychological harm on patients. Furthermore, it imposes a financial burden on both patients and physicians. This study aimed to analyze the medicolegal aspects of malpractice claims associated with aesthetic interventions. The study also aims to establish explicit criteria for identifying and differentiating positive cases from negative ones. This study is a retrospective descriptive observational analysis of medical malpractice claims related to aesthetic interventions. The data was obtained from the records of the Cairo Medicolegal Area between 2016 and 2020, encompassing a total of 98 cases in the study.

Results
The majority of cases were females (89.8%). The age group most significantly affected was between 26 to 35 years old. Plastic surgery accounted for the highest percentage (51%) of alleged cases among medical specialties. Consultants were the most frequently accused physicians (32.7%). Liposuction was the most frequent procedure (31.6%). Most of the malpractices occurred in private hospitals (45.9%). The outcome indicated that permanent infirmity accounted for 10.2%, while mortality constituted 3.1%.

Conclusions
The current study demonstrated that women constitute the predominant demographic in the examined malpractice cases, with plastic surgery being the most common area for alleged claims. The main complaints include disfigurement, dissatisfaction with results, and burn injuries. Aesthetic malpractice is more frequent in private hospitals than in general hospitals, frequently necessitating further treatment due to complications.
CRISPR/Cas genome editing for cotton precision breeding: mechanisms, advances, and prospects
Authors: Sheri Vijay , Mohan Harikrishnan , Jogam Phanikanth , Alok Anshu , Rohela Gulab Khan , Zhang Baohong 
Published: February 2025

Abstract
Cotton (Gossypium hirsutum L.) is one of the most important global crops that supports the textile industry and provides a living for millions of farmers. The constantly increasing demand needs a significant rise in cotton production. Genome editing technology, specifically with clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) tools, has opened new possibilities for trait development in cotton. It allows precise and efficient manipulation within the cotton genome when compared with other genetic engineering tools. Current developments in CRISPR/Cas technology, including prime editing, base editing, and multiplexing editing, have expanded the scope of traits in cotton breeding that can be targeted. CRISPR/Cas genome editing has been employed to generate effectively CRISPRized cotton plants with enhanced agronomic traits, including fiber yield and quality, oil improvement, stress resistance, and enhanced nutrition. Here we summarized the various target genes within the cotton genome which have been successfully altered with CRISPR/Cas tools. However, some challenges remain, cotton is tetraploid genome having redundant gene sets and homologs making challenges for genome editing. To ensure specificity and avoiding off-target effects, we need to optimize various parameters such as target site, guide RNA design, and choosing right Cas variants. We outline the future prospects of CRISPR/Cas in cotton breeding, suggesting areas for further research and innovation. A combination of speed breeding and CRISPR/Cas might be useful for fastening trait development in cotton. The potentials to create customized cotton cultivars with enhanced traits to meet the higher demands for the agriculture and textile industry.