bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and application of the DePtH framework for categorising the agentic demands of population health interventions
Authors: Garrott Kate , Ogilvie David , Panter Jenna , Petticrew Mark , Sowden Amanda , Jones Catrin P. , Foubister Campbell , Lawlor Emma , Ikeda Erika , Patterson Richard , Van Tulleken Dolly , Armstrong-Moore Roxanne , Vethanayakam Gokulan , Bo Lorna , White Martin , Adams Jean 
Published: October 2023

AbstractThe ‘agentic demand’ of population health interventions may influence intervention effectiveness and equity, yet the absence of an adequate framework to classify agentic demands limits the fields’ advancement. We systematically developed the DEmands for PopulaTion Health Interventions (DePtH) framework identifying three constructs influencing agentic demand - exposure (initial contact with intervention), mechanism of action (how the intervention enables or discourages behaviour), and engagement (recipient response), combined into twenty classifications. We conducted expert qualitative feedback and reliability testing, revised the framework and applied it in a proof-of-concept review, combining it with data on overall effectiveness and equity of dietary and physical activity interventions. Intervention components were concentrated in a small number of classifications; DePtH classification appeared to be related to intervention equity but not effectiveness. This framework holds potential for future research, policy and practice, facilitating the design, selection, evaluation and synthesis of evidence.
Home-Based Osteoporosis monitoring Using Bioelectrical Impedance Analysis: Muscle-to-Bone Mass Ratio
Authors: Zeng Jingqi , Jia Xiaobin 
Published: October 2023

AbstractOsteoporosis and its associated fractures affect nearly one-fifth of the global population, becoming a significant public health concern. While medical interventions can reduce these risks, Dual-energy X-ray Absorptiometry (DXA), the primary screening method, is limited due to its high cost, need for professional operation, and radiation exposure risks. However, in our Bioelectrical Impedance Analysis (BIA) conducted on 152,449 Chinese residents, we identified two distinct Muscle-to-Bone Mass Ratio (MBR) subgroups in both male and female elderly populations. The MBR range for males is 12.5-15.5 and 16.5-17.8; for females, it’s 11.2-15.2 and 16.5-18.2, with 16 being a significant threshold. Individuals with an MBR value exceeding 16 exhibit pronounced features of osteoporosis and an increased risk of fractures. For instance, the Bone Mineral Content (BMC) in males decreased by 19.18% (95%CI, 18.65%-19.73%), and in females by 29.84% (95%CI, 29.31%-30.36%). These individuals also showed lower body weight and BMI values. Females also displayed shorter stature and a higher body fat percentage, both indicators associated with osteoporosis. In contrast to the traditional Bone Mineral Density (BMD) T-score, the MBR sheds light on a specific physiological state in the elderly. In this condition, their risk of fractures significantly increases. This new understanding of osteoporosis suggests that we should not solely rely on the simple quantification of BMD. Furthermore, BIA measurements taken with domestic scales make MBR a safer, more efficient, and economical screening tool. This enables long-term MBR monitoring at home, offering continuous feedback for osteoporosis and fracture prevention, surpassing the limitations of DXA technology.
The Dilute domain of Canoe is not essential for Canoe’s role in linking adherens junctions to the cytoskeleton but contributes to robustness of morphogenesis
Authors: McParland Emily D. , Butcher T. Amber , Gurley Noah J. , Johnson Ruth I. , Slep Kevin C. , Peifer Mark 
Published: October 2023

AbstractRobust linkage between cell-cell adherens junctions and the actomyosin cytoskeleton allows cells to change shape and move during morphogenesis without tearing tissues apart. The multidomain proteinDrosophilaCanoe and its mammalian homolog Afadin are critical for this linkage, and in their absence many events of morphogenesis fail. To define underlying mechanisms, we are taking Canoe apart, usingDrosophilaas our model. Canoe and Afadin share five folded protein domains, followed by a large intrinsically disordered region. The largest of these folded domains is the Dilute domain, which is found in Canoe/Afadin, their paralogs, and members of the MyosinV family. To define the roles of Canoe’s Dilute domain we have combined biochemical, genetic and cell biological assays. Use of the AlphaFold tools revealed the predicted structure of the Canoe/Afadin Dilute domain, providing similarities and contrasts with that of MyosinV. Our biochemical data suggest one potential shared function: the ability to dimerize. We next generatedDrosophilamutants with the Dilute domain cleanly deleted. Surprisingly, these mutants are viable and fertile, and CanoeΔDIL protein localizes to adherens junctions and is enriched at junctions under tension. However, when we reduce the dose of CanoeΔDIL protein in a sensitized assay, it becomes clear it does not provide full wildtype function. Further, canoeΔDILmutants have defects in pupal eye development, another process that requires orchestrated cell rearrangements. Together, these data reveal the robustness in AJ-cytoskeletal connections during multiple embryonic and postembryonic events, and the power of natural selection to maintain protein structure even in robust systems.
The role of theta and gamma oscillations in item memory, source memory, and memory confidence
Authors: Wynn Syanah C. , Townsend Christopher D. , Nyhus Erika 
Published: October 2023

AbstractTheta and gamma oscillations have been linked to episodic memory processes in various studies. Both oscillations seem to be vital for processes guided by the medial temporal lobe, such as the retrieval of information from memory. While theta oscillations increase with successful memory, it is unclear what the unique contribution of theta is to various subcomponents of memory. On the other hand, memory-related gamma oscillations have been mainly reported in the hippocampus, leaving the role of neocortical gamma in memory underexplored. In the current study, we explored how unique variability in memory accuracy and memory confidence contributes to fluctuations in theta and gamma power. To this end, we recorded EEG from 54 participants while they performed a source memory task. From this task we obtained their item memory accuracy, source memory accuracy, item memory confidence, and source memory confidence. These behavioral measures were put in a trial-by-trial linear mixed effects model to uncover their unique contribution to the oscillatory power in frontal and parietal regions. Our results are in line with the involvement of theta oscillations in both memory accuracy and confidence, but seem to indicate a main role for theta oscillations in memory-related confidence. In addition, we found that gamma oscillations play various roles in memory-processing, dependent of brain region.
Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation
Authors: Sterrett Maria C. , Cureton Lauryn A. , Cohen Lauren N. , van Hoof Ambro , Khoshnevis Sohail , Fasken Milo B. , Corbett Anita H. , Ghalei Homa 
Published: October 2023

ABSTRACTThe RNA exosome is an evolutionarily conserved exoribonuclease complex that consists of a 3- subunit cap, a 6-subunit barrel-shaped core, and a catalytic base subunit. Missense mutations in genes encoding structural subunits of the RNA exosome cause a growing family of diseases with diverse pathologies, collectively termed RNA exosomopathies. The disease symptoms vary and can manifest as neurological defects or developmental disorders. The diversity of the RNA exosomopathy pathologies suggests that the different missense mutations in structural genes result in distinctin vivoconsequences. To investigate these functional consequences and distinguish whether they are unique to each RNA exosomopathy mutation, we generated a collection ofin vivomodels using budding yeast by introducing pathogenic missense mutations in orthologousS. cerevisiaegenes. We then performed a comparative RNA-seq analysis to assess broad transcriptomic changes in each mutant model. Three of the mutant modelsrrp4-G226D, rrp40-W195Randrrp46-L191H, which model mutations in the genes encoding structural subunits of the RNA exosome,EXOSC2, EXOSC3andEXOSC5showed the largest transcriptomic differences. Further analyses revealed shared increased transcripts enriched in translation or ribosomal RNA modification/processing pathways across the three mutant models. Studies of the impact of the mutations on translation revealed shared defects in ribosome biogenesis but distinct impacts on translation. Collectively, our results provide the first comparative analysis of several RNA exosomopathy mutant models and suggest that different RNA exosomopathy mutations result inin vivoconsequences that are both unique and shared across each variant, providing more insight into the biology underlying each distinct pathology.
Describing the landscape of medical education preprints on medRxiv
Authors: Maggio Lauren A. , Costello Joseph A. , Artino Anthony R. 
Published: October 2023

AbstractIntroductionA preprint is a version of a research manuscript posted to a preprint server prior to peer review. Preprints enable authors to quickly and openly share research, afford opportunities for expedient feedback, and enable immediate listing of research on grant and promotion applications. In medical education, most journals welcome preprints, suggesting they play a role in the field’s discourse. Yet, little is known about medical education preprints, including author characteristics, use, and ultimate publication status. This study provides an overview of preprints in medical education in an effort to better understand their role in the field’s discourse.MethodsThe authors queried medRxiv, a preprint repository, to identify preprints categorized asMedical Educationand downloaded the related metadata. CrossRef was queried to gather information on preprints later published in journals.ResultsBetween 2019-2022, 204 preprints were classified in medRxiv asMedical Educationwith most deposited in 2021 (n=76, 37.3%). On average, preprint full-texts were downloaded 1875.2 times, and all were promoted on social media. Preprints were authored, on average, by 5.9 authors. Corresponding authors were based in 41 countries with nearly half (45.6%) in the United States, United Kingdom, and Canada. Almost half (n=101, 49.5%) of preprints became published articles in predominantly peer-reviewed journals. Preprints appeared in 65 peer-reviewed journals withBMC Medical Education(n=9, 8.9%) most represented.DiscussionMedical education research is being deposited as preprints, which are promoted, heavily accessed, and subsequently published in peer-reviewed journals, including those specific to medical education. Considering the benefits of preprints and slowness of medical education publishing, it is likely that preprint deposition will increase and preprints will be integrated into the field’s discourse. Based on these findings, we propose next steps to facilitate the responsible and effective creation and use of preprints in medical education.
Barriers to adoption of work–life balance practices amongst construction companies in Lagos, Nigeria: an exploratory factor analysis
Authors: Osuizugbo Innocent Chigozie , Oshodi Olalekan Shamsideen , Kukoyi Patricia Omega , Lawani Amos Okemukoko , Onokwai Anthony Ogochukwu 
Published: October 2023

PurposeThe current study seeks to investigate and determine the principal barriers to the adoption of work–life balance (WLB) practices amongst construction companies operating in the developing countries using Lagos, Nigeria as a case study.Design/methodology/approachThis study adopts a survey research technique. Snowball sampling technique was adopted to identify the target respondents for the administration of questionnaire. A total of 156 questionnaires were distributed and a response rate of 66% (103 questionnaires were completely filled and returned) was attained. Data elicited were analysed using descriptive and inferential statistics.FindingsThe results from the exploratory factors analysis show that the principal barriers to the adoption of WLB practices amongst construction companies in Lagos, Nigeria are categorised into four components: nature of construction job and limited evidence on impact of WLB, support, awareness and culture, lack of involvement of management staff and organisational factors.Originality/valueThis study contributed to more effective WLB studies by highlighting the barriers to the adoption of WLB practices in the construction sector. An understanding of these barriers can aid policy makers and management personnel in construction organisations as well as facilitate development of strategies required to reduce the barriers to WLB practices in the construction sector.
Examining the linkages between ICTs, economic development and the sustainable development goals: evidence based on the ICT4D value chain
Authors: Alhassan Muftawu Dzang , Nuoterah Louis , Adam Ibrahim Osman , Seini Adiata Borresa , Bukari Awal , Naatu Stephen , Issah Mudasir 
Published: October 2023

Purpose
Globally, information and communication technology (ICT) is regarded as a reliable tool that facilitates economic development and propels sustainable development. However, little empirical work exists on the specific effects of ICT access and usage on economic and sustainable development. This paper aims to investigate the nexus between ICTs, economic and sustainable development at the global level.

Design/methodology/approach
This paper presents ICT for Development (ICT4D) value chain empirical evidence on the linkages between ICTs, economic development and sustainable development goals (SDGs). The research model based on the capability approach is validated by using archival data from 130 global countries and partial least squares–structural equation modelling.

Findings
The findings reveal that ICT access and usage significantly influence a country’s attainment of the SDGs. Whilst ICT access plays a crucial role in promoting economic development, ICT usage does not. Also, findings show that economic development significantly mediated the nexus between ICT access and SDGs but not between ICT usage and SDGs. This calls for countries to ensure that access to ICTs is accompanied by a low cost of usage to achieve the full benefits of economic and sustainable development.

Originality/value
Using the ICT4D value chain, this paper empirically shows how ICT readiness and availability in the form of ICT access and ICT uptake (individual ICT use) promote economic development and SDGs (impact). Furthermore, with many studies conducted on SDGs at the country level, this study provides a broader understanding of the roles of ICT access and use on SDGs at the global level. This allows for easy generalisability and reproducibility of results.
Employees as decision-makers: coordinating empowerment at all levels
Authors: Evans Klavdia Markelova , Salaiz Ashley , McKee Rob Austin 
Published: October 2023

Purpose
This paper aims to address an important question of what makes companies succeed or not in their attempt to empower employees. As this study answers this question, the arguments suggest that coordination is essential to creation of employee empowerment climate in organizations.

Design/methodology/approach
This is conceptual paper rooted in extensive research on both – empowerment (culture, climate and organizational structure) and coordination (formal and informal).

Findings
To help managers to be effective in their roles, this study presents four insights to creating empowerment climate. The arguments conclude that coordination provides a vessel for successful realization of empowerment. Specifically, only informal coordination (vs formal) will fully realize empowerment’s benefits. Given that the topic of empowerment is highly germane to managers in today’s context of the increasing number of employees working remotely, this work presents an important and actionable advance for managers.

Originality/value
This study represents original research that has not been published and is not currently under review at any other journal.
European approach to remote customer onboarding solutions
Authors: Cookman Daniel 
Published: October 2023

Purpose
This study aims to identify European positioning on the use of remote customer onboarding solutions in combating financial crime.

Design/methodology/approach
This study is a desktop research that examines European Banking Authority (EBA) policy statements relating to the use of innovative solutions in combating financial crime.

Findings
Technological advancements in biometric data and software tools provide a unique opportunity to address potential paper customer onboarding process deficiencies. Electronic remote customer onboarding solutions equip credit, financial institutions and investment firms with an alternative FTE cost-saving solution, in their pursuit of revenue generation. Whilst the EBA and Financial Action Task Force have provided approval for the utilisation of innovative solutions and AML technologies in combatting financial crime. Hesitancy remains on the ability of credit and financial institutions to use technological solutions as a “magic solution” in preventing the materialisation of money laundering/terrorist financing related risks. Analysis of policy suggests a gravitation towards the increased use of the aforementioned technologies in the interim.

Originality/value
Capitalisation of European banking authority.
Do pro-diversity beliefs enhance OCB? The joint effects of gender diversity and diversity beliefs on group organizational citizenship behavior through collective personality fit
Authors: Sung Sang Hun , Seong Jee Young , Hong Doo-Seung , Zhang Linyuan 
Published: October 2023

PurposeThis paper investigates the interaction effects of gender diversity and diversity beliefs on group-level personality fit (“collective personality fit”) and group organizational citizenship behavior (GOCB). It seeks to provide a sufficient understanding of the under-researched area, such as how group composition impacts group behavioral outcomes.Design/methodology/approachData were collected from 453 employees and their leaders in 63 teams of Korean private sector firms using a moderated-mediation model.FindingsThis study found that high diversity beliefs can weaken the negative effects of gender diversity on collective personality fit and further enhance GOCB. The results confirm the moderated-mediation effect of diversity beliefs in the relationship between gender diversity and GOCB.Practical implicationsManagement should realize that the negative effect of workforce diversity on GOCB can be reduced by boosting collective personality fit in the team. In this process, enhancing diversity beliefs may relieve the adverse effects on GOCB caused by workgroup gender differences.Originality/valueThis study develops a group-level model proposing that the interaction effects of gender diversity and high diversity beliefs enable a high level of collective personality fit, enhancing GOCB. It attempts to investigate the effects of gender diversity at the group level under boundary conditions.
Impact of chiglitazar on glycemic control in type 2 diabetic patients with metabolic syndrome and insulin resistance: A pooled data analysis from two phase III trials
Authors: Ning Zhiqiang , Ai Guoqiang , Chen Bo , Yao He , Cao Haixiang , Pan Desi , Lu Xianping 
Published: October 2023

AbstractBackgroundTo evaluate the glycemic control effects of vhiglitazar (carfloglitazar), a novel peroxisome proliferator‐activated receptor pan‐agonist, in patients with type 2 diabetes mellitus (T2DM) with metabolic syndrome (MetS) or insulin resistance (IR) using pooled data analysis of two phase III clinical trials.MethodsData were collected from two randomized phase III clinical trials in China, comparing chiglitazar to placebo or sitagliptin in T2DM patients. The MetS was defined by the Adult Treatment Panel III MetS criteria, and IR was defined by homeostatic model assessment for insulin resistance (HOMA‐IR) ≥4.31 (male) or 4.51 (female). The main end point of this analysis was glycemic control in the different arms within each subgroup.ResultsIn the MetS subgroup, changes in glycated hemoglobin (HbA1c) from baseline at week 24 in the chiglitazar 32 mg, chiglitazar 48 mg, and sitagliptin 100 mg arms were −1.44%, −1.68%, and −1.37%, respectively; p < .05 was obtained when chiglitazar 48 mg was compared with sitagliptin. In the IR subgroup, the changes in HbA1c were −1.58%, −1.56%, and −1.26% in chiglitazar 32 mg, chiglitazar 48 mg, and sitagliptin 100 mg arms, respectively; p < .05 was obtained when chiglitazar 32 mg was compared with sitaligptin. The two doses of chiglitazar demonstrated a greater reduction in fasting plasma glucose and 2 h postprandial plasma glucose than sitagliptin in the pooled population and in the MetS and IR subgroups.ConclusionsChiglitazar shows promising efficacy for glycemic control in patients with T2DM associated with MetS or IR. Further prospective trials are required to validate these findings.
Characteristics of race/ethnicity in trials leading to anti‐rheumatic drug approval for inflammatory arthritis by the US Food and Drug Administration
Authors: Xie Yan , Liu Yang , Qin Yunhe , Chen Xiaoyuan , Xie Qibing 
Published: October 2023

AbstractObjectivePresenting the racial/ethnic representation in clinical trials leading to new approvals of inflammatory arthritis (IA) by the US Food and Drug Administration (FDA) to determine the extent of racial/ethnic disparities.MethodsPivotal trials supporting the approval of new indications from July 2012 to June 2022 were collected from Drugs@FDA, the FDA‐approved drugs database. More details were then identified by searching Pubmed and the National Institutes of Health trials registry. General characteristics of the approved drugs and demographic data for each pivotal trial, especially the race/ethnicity data, were collected. The enrollment profiles of each race/ethnicity were analyzed and then compared with the 2020 US census data.ResultsFrom 2012 to 2022, 34 new approvals were identified based on 59 clinical trials. The Black was consistently underrepresented in all subtypes of IA and drugs, while the White was overrepresented compared to the 2020 US census data.For Asian and Hispanic participants, these pivotal trials presented relatively heterogeneities in enrollments. As for the trends over time, increased involvements of White were still observed in rheumatoid arthritis (RA), psoriatic arthritis, and spondyloarthritis, while increased involvements of Black and decreased enrollments of Asian and Hispanic were only observed in RA.ConclusionsDespite many efforts to eliminate racial/ethnic disparities, the Black was consistently underrepresented in pivotal clinical trials compared to the 2020 US national race/ethnicity distribution data. The White was consistently overrepresented, and the Hispanic presented heterogeneous results. No evident time trend was observed.