bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impella device in fulminant myocarditis: Japanese Registry for Percutaneous Ventricular Assist Device (J-PVAD) registry analysis on outcomes and adverse events
Authors: Nasu Takahito , Ninomiya Ryo , Koeda Yorihiko , Morino Yoshihiro 
Published: December 2023

Abstract

Aims
Given that fulminant myocarditis, characterized by unstable haemodynamics, is a significant clinical challenge and that traditional pharmacological treatments have limitations, evaluating alternatives such as the Impella device is a crucial focus of this study. Further, this study presents pioneering large-scale registry data on its use in managing fulminant myocarditis.

Methods and results
Data from the Japanese Registry for Percutaneous Ventricular Assist Devices (J-PVAD) were analysed to assess Impella’s role in managing fulminant myocarditis from February 2020 to December 2021. The primary outcome was 30-day mortality for those treated with Impella. Of the 269 patients treated with Impella, 107 used Impella standalone, and 162 used ECPELLA (Impella combined with extracorporeal membrane oxygenation). The average age was 54 years, with 42.8% females. Overall, 74.3% survived at 30 days. Specifically, the success rate was 68.5% for the ECPELLA group and 83.2% for the Impella standalone group. Cox regression highlighted that lower estimated glomerular filtration rate and pre-Impella systolic blood pressure increased adverse event risk, while Swan–Ganz catheterization use reduced it. Adverse events were noted in 48.7% of patients, such as bleeding (32.0%) and deteriorating renal function (8.6%).

Conclusion
Impella’s use in fulminant myocarditis demonstrates encouraging short-term outcomes, albeit with significant adverse events. These findings align with previous mechanical circulatory support studies, emphasizing caution regarding haemorrhagic issues. Further studies are essential to enhance patient selection and treatment approaches.
Multisystem inflammatory syndrome in adults with cardiac engagement: a case report and literature review
Authors: Massoud Linda , Westling Katarina , Fischer Marie , Najjar Emil 
Published: December 2023

Abstract

Background
Following infection with severe acute respiratory syndrome coronavirus, a post-infectious multisystem inflammatory syndrome in adults (MIS-A) has been identified. It affects multiple organ systems and can lead to multi-organic failure.

Case summary
This case report describes a patient with MIS-A with significant cardiac involvement including peri-myocarditis, pulmonary hypertension, right-sided heart failure, tricuspid regurgitation, and cardiogenic shock. After being diagnosed and treated correctly for MIS-A, the patient recovered completely, without any cardiac sequelae.

Discussion
The hyperinflammation in MIS-A can have cardiac engagement. Although more research is required to further clarify the underlying mechanisms, prompt diagnosis and anti-inflammatory treatment are crucial for better outcomes and cardiac recovery.
Modelling perspective on the climate footprint in south east Australian marine waters and its fisheries
Authors: Fulton Elizabeth A , Mazloumi Nastaran , Puckeridge Aaron , Hanamseth Roshan 
Published: December 2023

Abstract
South eastern Australia is a global warming hotspot, and is also home to ~70% of Australia’s population and one of Australia’s largest fisheries—the South East Scalefish and Shark Fishery. This fishery spans shelf to deep waters, subtropical to temperate waters, employs many gears, and interacts with over 100 species. Despite following best practice fisheries management principles, including taking an ecosystem perspective to overall fisheries interactions, management interventions have failed to arrest or recover the decline of some focal species. Using an Atlantis ecosystem model developed for the fishery over the past 20 years, this paper presents simulations that suggest climate change may be a major contributor to the trajectories seen for a number of species—such as jackass morwong (Nemadactylus macropterus), blue warehou (Seriolella brama), and gemfish (Rexea solandri). This kind of climate influence poses many challenges for fisheries management into the future, raising questions about what to do when climate change undermines or overrides fisheries management actions and objectives.
Super-resolution of positive near-colliding point sources
Authors: Liu Ping , Ammari Habib 
Published: December 2023

AbstractIn this paper, we analyze the capacity of super-resolution (SR) of one-dimensional positive sources. In particular, we consider a similar setting as in Batenkov et al. (2020, Inf. Inference, 10, 515–572) and restrict the results to the specific case of super-resolving positive sources. To be more specific, we consider resolving $d$ positive point sources with $p \leqslant d$ nodes closely spaced and forming a cluster, while the rest of the nodes are well separated. Our results show that when the noise level $\epsilon \lesssim \mathrm{SRF}^{-2 p+1}$, where $\mathrm{SRF}=(\varOmega \varDelta )^{-1}$ with $\varOmega $ being the cutoff frequency and $\varDelta $ the minimal separation between the nodes, the minimax error rate for reconstructing the cluster nodes is of order $\frac{1}{\varOmega } \mathrm{SRF}^{2 p-2} \epsilon $, while for recovering the corresponding amplitudes $\{a_j \}$, the rate is of order $\mathrm{SRF}^{2 p-1} \epsilon $. For the non-cluster nodes, the corresponding minimax rates for the recovery of nodes and amplitudes are of order $\frac{\epsilon }{\varOmega }$ and $\epsilon $, respectively. Compared with results for complex sources in Batenkov et al. (2020, Inf. Inference, 10, 515–572), our findings reveal that the positivity of point sources actually does not mitigate the ill-posedness of the SR problem. Although surprising, this fact does not contradict positivity’s significant role in the convex algorithms. In fact, our findings are consistent with existing convex algorithms’ stability results for resolving separation-free positive sources, validating their superior SR capabilities. Moreover, our numerical experiments demonstrate that the Matrix Pencil method perfectly meets the minimax rates for resolving positive sources.
Paul Graupe, Arthur Goldschmidt and the dispute over an Adriaen van Ostade painting in wartime France
Authors: Reed Victoria S 
Published: December 2023

Abstract
In 2023 the Museum of Fine Arts, Boston, the collectors Susan and Matthew Weatherbie, and the heirs of the Jewish art dealers Paul Graupe and Arthur Goldschmidt reached a financial settlement over Adriaen van Ostade’s Customers Conversing in a Tavern. The museum had been alerted to a potential claim on the painting in 2017 while conducting research on promised gifts from the Weatherbies’ collection. At that time, the van Ostade was registered as a Nazi-era loss by the heirs of Graupe. Research revealed that it was handled by Graupe and his associate Goldschmidt when they were trying to flee Nazi-occupied Europe. This article provides insight into the working relationship of Graupe and Goldschmidt, and offers clues to the fate of other works of art placed in their custody which heirs of Holocaust victims may be seeking. It also offers a roadmap for museums navigating similar provenance research, donor relations and collection management questions.
Exploring wearable technology use and importance of health monitoring in the hazardous occupations of first responders and professional drivers
Authors: Tucker Sarah , Jonnalagadda Soundarya , Beseler Cheryl , Yoder Aaron , Fruhling Ann 
Published: December 2023

Abstract
Objectives: Hazardous materials (HAZMAT) pose risks to the health and safety of professionals involved with transportation and emergency responses. Two distinct occupational groups that encounter HAZMAT events are first responders and professional drivers. Wearable technology is a tool that can assist with monitoring the health of professionals involved in HAZMAT events. The aim of this study was to compare and evaluate the perceptions of first responders and professional drivers on wearable technology and attitudes toward health monitoring.
Methods: A survey was administered to first responders (n = 112) and professional drivers (n = 218). Statistical approaches included bivariate analysis, latent class analysis, logistic regression analysis, and path analysis for the variables of interest.
Results: There were significant differences between the groups in perceptions of the benefits of monitoring certain health indicators. Professional drivers were more likely to have a history of wearable technology use compared with first responders (odds ratio [OR] = 10.1; 95% CI, 4.42-22.9), reported greater exposure to HAZMAT (OR = 4.32; 95% CI, 2.24-8.32), and were more willing to have their health data monitored by someone other than themselves (OR = 9.27; 95% CI, 3.67-23.4). A multinomial regression model revealed that occupation was not a significant predictor of class preference for acceptance of monitoring specific health indicators.
Conclusions: Occupation appeared to be important but further analysis uncovered that characteristics of individuals within the occupations were more salient to the use of wearable technology. HAZMAT exposure, someone else monitoring health data, and experience with wearable technology use were found to be important factors for perceptions about benefits of health monitoring with wearable technology.
Risk of metabolic syndrome among law enforcement officers due to physical activity and posture behaviors
Authors: Johnson Marquell , Braun Saori , Hecimovich Michelle , Schultz Katrina , Bauer Chantal , Bohn Anna , Janot Jeff 
Published: December 2023

Abstract
Background: There are limited data on objectively measured activity and postural behaviors of law enforcement officers (LEOs) in relation to risk of metabolic syndrome (MetS).
Objectives: To examine the associations between objectively measured activity and postural behaviors and MetS risk among LEOs.
Methods: Thirty-one LEOs, mean (SD) age 33 (10) years, participated in the study. LEOs had their metabolic risk factors measured using blood samples after fasting for at least 10 hours prior to testing. Participants wore activity-monitoring devices for 7 consecutive days during on-duty and off-duty shifts. Eighteen participants adhered to wearing the devices. Descriptive statistics were used to determine means for all MetS risk factors; time in intensity-specific physical activity behaviors; and time in various postural shifts. Correlation analyses were employed to examine relationships between activity behaviors, postures, and MetS risk factors.
Results: Over half (51.6%; n = 16) of the participants had 2 or more positive MetS risk factors. Mean (SD) on-duty sedentary behavior was 273 (59) minutes compared with off-duty sedentary behavior of 401 (146) minutes. Mean on-duty moderate-intensity activity was 236 (40) minutes compared with off-duty moderate-intensity activity of 305 (80) minutes. Average on-duty sitting time was 435 (69) minutes compared with off-duty sitting time of 528 (142) minutes. Average on-duty standing time was 116 (43) minutes compared with off-duty standing time of 171 (51) minutes. There were negative correlations between on-duty sedentary activity and Systolic Blood Pressure (r = −0.48) and Diastolic Blood Pressure (r = −0.48), respectively.
Conclusions: Law enforcement officers have unfavorable activity and postural behaviors during a typical day regardless of working status and may be at risk for developing MetS.
Downstream influence of turbulent flow past vortex generators
Authors: Huang Yi-Xuan , Chung Ping-Han , Chung Kung-Ming , Huang Chih-Yung 
Published: December 2023

Abstract
Vortex generators (VGs) are typically positioned upstream of a boundary layer separation region. Their effectiveness depends on incoming flow conditions (Mach number, Reynolds number, and boundary layer characteristics), geometrical configuration (vane or ramp, height, width, and angle of incidence), and spacing. Device-induced vortices and following decay allow VGs to be used as a passive control device. This study uses pressure-sensitive paint to determine the global surface pressure pattern for a flat plate flow in the presence of VGs (counter-rotating vanes, co-rotating vanes and ramps). The freestream Mach number is 0.64 and 0.83. The ratio between the height of the VGs and the incoming boundary layer thickness is 0.2, 0.5, and 1.0. The standard deviation in the spanwise pressure in the streamwise direction is used to determine the downstream influence of turbulent flow past VGs. Increasing the height of VGs causes device-induced vortices to propagate farther downstream.
Incidence of anaphylaxis to YF-VAX® yellow fever vaccination: a retrospective evaluation of vaccine adverse event reports 1999–2018
Authors: McClenathan Bruce M , Taylor Jillian N , Housel Laurie A , Ryan Margaret 
Published: December 2023

Abstract

Background
The incidence of anaphylaxis after receipt of yellow fever (YF) vaccine is highly variable based upon previously published reports. Anaphylaxis after receiving the YF vaccine has been reported to range from 0 up to 22 per 1 000 000 doses. Our clinical experience suggested increased incidence, which prompted our investigation. We sought to evaluate the current incidence rate of anaphylaxis after receipt of the 17D-204 strain YF-VAX® brand reported in the US.

Methods
We performed a retrospective review of the Vaccine Adverse Event Reporting System (VAERS) reports of anaphylaxis after receiving the YF-VAX vaccine occurring between 1 October 1999 and 30 September 2018. We utilized the Brighton Collaboration Case Definition and inclusion determination was made by a board-certified allergist. We also obtained the total number of YF-VAX doses distributed across the US during this same time-period and then calculated an updated incidence rate of YF-VAX vaccine-associated anaphylaxis.

Results
We identified 132 potential cases of possible or probable anaphylaxis. Of these, 111 met inclusion criteria: level 1 (n = 51), level 2 (n = 59) and level 3 (n = 1). The manufacturer reported a total distribution of 7 624 160 doses of YF-VAX from 1 October 1999 to 30 September 2018. The calculated incidence rate of YF-VAX vaccine-associated anaphylaxis is estimated at 14.6 events per 1 000 000 doses.

Conclusions
We conclude the estimated rate of anaphylaxis per VAERS reports is 14.6 events per 1 000 000 doses after YF-VAX vaccination. This is consistent with some previous reports and substantially higher than rates of anaphylaxis after other vaccines.
Safety and effectiveness of peficitinib 100 mg/day in patients achieving clinical remission from a long-term open-label extension study in Japan, Korea, and Taiwan (RAJ2)
Authors: Tanaka Yoshiya , Takeuchi Tsutomu , Morita Yoshiaki , Kaneko Yuichiro , Terada Wataru 
Published: December 2023

ABSTRACT

Objectives
This post hoc analysis of the RAJ2 study assessed long-term safety and effectiveness of peficitinib 100 mg/day for treatment of rheumatoid arthritis.

Methods
Eligible patients previously completed two Phase 3 (RAJ3 and RAJ4) studies of peficitinib in Asia. All patients received peficitinib 100 mg/day at RAJ2 Week (W)0; dose change to 50 mg/day or 150 mg/day was permitted. Safety endpoints included treatment-emergent adverse events and laboratory test results. Effectiveness endpoints included peficitinib exposure pattern, achievement of Clinical Disease Activity Index (CDAI) remission by peficitinib exposure pattern at W0 and W48, and association of demographics/characteristics with CDAI remission at W0 and W48.

Results
Overall, no new safety findings were reported at W48, and renal function was unaffected. Of patients included in effectiveness analyses at W48, 70.9% (451/636) had maintained peficitinib 100 mg/day since W0. Of patients who achieved CDAI remission at W0 and maintained peficitinib 100 mg/day to W48, 50.3% (79/157) maintained CDAI remission to W48. Low disease activity and a lower number of prior disease-modifying antirheumatic drugs were significantly associated with CDAI remission at W48.

Conclusions
Long-term peficitinib treatment at a dose of 100 mg/day was generally well tolerated and, following induction therapy, maintained effectiveness through to W48.
A Retrospective Study: Reduction of Anxiety Through Music Therapy During Hospitalization
Authors: Brown Chelsea S , Patmon Frances , Freilich Joshua , Heiderscheit Annie 
Published: December 2023

Abstract
This retrospective review of 56 charts of adult hospital patients examined verbal anxiety ratings (VAR) of premusic therapy- and post-music therapy sessions to report on the preliminary efficacy of live music interventions on anxiety. Due to the high rate of anxiety associated with hospitalization and its negative somatic and psychological effects, it is important that anxiety is assessed and treated by qualified professionals. Nonpharmacological approaches such as music therapy help to address the root of anxiety by providing a relaxation cue to patients’ parasympathetic nervous system and also address patients’ psychological concerns. This retrospective analysis explores the real-world evidence of music therapy for the treatment of hospital-associated anxiety symptoms through a review of all music therapy sessions with a charted verbal anxiety rating (VAR) ≥3 documented in the electronic health record. Paired samples t-test showed that music therapy sessions resulted in a statistically significant reduction in pre- and post-verbal anxiety rating; t(60) = 9.806, p &lt; .001. This study demonstrates that music therapy is a feasible treatment modality for assessing and ameliorating self-reported anxiety symptoms in hospitalized adults.
The nuclease-associated short prokaryotic Argonaute system nonspecifically degrades DNA upon activation by target recognition
Authors: Lu Xueling , Xiao Jun , Wang Longfei , Zhu Bin , Huang Fengtao 
Published: December 2023

Abstract
Prokaryotic Argonautes (pAgos) play a vital role in host defense by utilizing short nucleic acid guides to recognize and target complementary nucleic acids. Despite being the majority of pAgos, short pAgos have only recently received attention. Short pAgos are often associated with proteins containing an APAZ domain and a nuclease domain including DUF4365, SMEK, or HNH domain. In contrast to long pAgos that specifically cleave the target DNA, our study demonstrates that the short pAgo from Thermocrispum municipal, along with its associated DUF4365-APAZ protein, forms a heterodimeric complex. Upon RNA-guided target DNA recognition, this complex is activated to nonspecifically cleave DNA. Additionally, we found that the TmuRE-Ago complex shows a preference for 5′-OH guide RNA, specifically requires a uridine nucleotide at the 5′ end of the guide RNA, and is sensitive to single-nucleotide mismatches between the guide RNA and target DNA. Based on its catalytic properties, our study has established a novel nucleic acid detection method and demonstrated its feasibility. This study not only expands our understanding of the defense mechanism employed by short pAgo systems but also suggests their potential applications in nucleic acid detection.
A tailed mirtron promotes longevity in Drosophila
Authors: Khanal Sweta , de Cruz Matthew , Strickland Britton , Mansfield Kody , Lai Eric C , Flynt Alex 
Published: December 2023

Abstract
Thousands of atypical microRNAs (miRNAs) have been described in the genomes of animals; however, it is unclear if many of these non-canonical miRNAs can measurably influence phenotypes. Mirtrons are the largest class of non-canonical miRNAs that are produced from hairpins excised by splicing, which after debranching become substrates for Dicer and load into RISC. Most mirtrons require additional processing after splicing to remove ‘tail’ residues interposed between one of the host intron splice sites and base of the hairpin precursor structure. Despite most mirtrons requiring tail removal no function has been elucidated for a tailed species, indeed for all mirtrons identified function has only been assigned to a single species. Here we study miR-1017, a mirtron with a 3′ tail, which is well expressed and conserved in Drosophila species. We found that miR-1017 can extend lifespan when ectopically expressed in the neurons, which seems partly due to this miRNA targeting its host transcript, acetylcholine receptor Dα2. Unexpectedly we found that not only did miR-1017 function in trans but also in cis by affecting splicing of Dα2. This suggests a mechanism for mirtron evolution where initial roles of structural elements in splicing lead to secondary acquisition of trans-regulatory function.
Magnetic activity variability of nearby bright Sun-like stars by 4 yr intensive Hα line monitoring
Authors: Lee Sanghee , Notsu Yuta , Sato Bun’ei 
Published: December 2023

Abstract
We report intensive monitoring of the activity variability in the Hα line for 10 Sun-like stars using the 1.88 m reflector at Okayama Branch Office, Subaru Telescope, during the last four years (2019–2022). Our aim was to investigate features of the stellar magnetic activity behavior. We correlated the Hα line variability of each star with the stellar activity levels derived from the Ca ii H&K line, suggesting its efficiency as a magnetic activity indicator. In analyzing the Hα line variation, we observed that some stars exhibited linear or quadratic trends during the observation period. Among several G- and K-type stars expected to have co-existing activity cycles, we confirmed the 2.9 yr short cycle of ϵ Eri (K2V) from the Hα observations. Additionally, we established upper limits on the Hα variability of β Com (G0V) and κ1 Cet (G5V) concerning their expected shorter cycles. We also detected the possibility of short-term activity cycles in two F-type stars, β Vir (F9V; ∼530 d) and α CMi (F5IV-V; ∼130 d). The cycle in α CMi was observed in only one season of our 4 yr observations, suggesting the temporal absence of the cycle period. However, for stars with planets, we did not observe significant magnetic activity variability likely associated with the planetary orbital period. It is speculated that the impact of Hα variability on radial velocity (RV) measurements may vary with spectral type.
The extracellular vesicle proteomes of Sorghum bicolor and Arabidopsis thaliana are partially conserved
Authors: Chaya Timothy , Banerjee Aparajita , Rutter Brian D , Adekanye Deji , Ross Jean , Hu Guobin , Innes Roger W , Caplan Jeffrey L 
Published: December 2023

Abstract
Plant extracellular vesicles (EVs) are membrane-bound organelles involved mainly in intercellular communications and defense responses against pathogens. Recent studies have demonstrated the presence of proteins, nucleic acids including small RNAs, and lipids along with other metabolites in plant EVs. Here, we describe the isolation and characterization of EVs from sorghum (Sorghum bicolor). Nanoparticle tracking analysis, dynamic light scattering, and cryo-electron tomography showed the presence of a heterogeneous population of EVs isolated from the apoplastic wash of sorghum leaves. Cryo-electron microscopy revealed that EVs had a median size of 110 nm and distinct populations of vesicles with single or multiple lipid bilayers and low or high amounts of contents. The heterogeneity was further supported by data showing that only a subset of EVs that were stained with a membrane dye, Potomac Gold, were also stained with the membrane-permeant esterase-dependent dye, calcein acetoxymethyl ester. Proteomic analysis identified 437 proteins that were enriched in multiple EV isolations, with the majority of these also found in the EV proteome of Arabidopsis (Arabidopsis thaliana). These data suggest a partial conservation of EV contents and function between the monocot, sorghum, and a distantly related eudicot, Arabidopsis.