bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Endovascular Fenestrated and Branched Grafts vs open Surgery in Thoracoabdominal Aortic Aneurysm Repair
Authors: Vigezzi Giacomo Pietro , Barbati Chiara , Blandi Lorenzo , Guddemi Annalisa , Melloni Andrea , Salvati Simone , Bertoglio Luca , Odone Anna ,   on behalf of the HTA PRO-ENDO commission investigators
Published: January 2024

Objective:To provide an updated systematic review and meta-analysis with meta-regression of safety and efficacy of fenestrated/branched endovascular repair of thoracoabdominal aortic aneurysms (TAAAs) compared with open repair.Summary Background Data:Endovascular repair of TAAAs may be a promising alternative to open surgery by reducing invasiveness and expanding the eligible population, but evidence remains limited.Methods:We applied PRISMA to retrieve, quantitatively pool, and critically evaluate the efficacy and safety (including 30-day mortality, reintervention, spinal cord injury, SCI, and renal injury) of both approaches. Original studies were retrieved from PubMed, Embase and Cochrane Library until 20 April 2022, excluding papers reporting less than 10 patients. Pooled proportions and means were determined using a random-effects model. Heterogeneity between studies was evaluated with I2statistics.Results:Sixty-four studies met the pre-defined inclusion criteria. Endovascular cohort patients were older and had higher rates of comorbidities. Endovascular repair was associated with similar proportions of mortality (0.07, 95% confidence interval, CI, 0.06-0.08) compared with open repair (0.09, 95%CI 0.08-0.12;P-value=0.22), higher proportions of reintervention (0.19, 95%CI 0.13-0.26, vs. 0.06, 95%CI 0.04-0.10;P-value<0.01), similar proportions of transient SCI (0.07, 95%CI 0.05-0.09, vs. 0.06, 95%CI 0.05-0.08;P-value=0.28), lower proportions of permanent SCI (0.04, 95%CI 0.03-0.05, vs. 0.06, 95%CI 0.05-0.07;P-value<0.01) and renal injury (0.08, 95%CI 0.06-0.10, vs. 0.13, 95%CI 0.09-0.17;P-value=0.02). Results were affected by high heterogeneity and potential publication bias.Conclusions:Despite these limitations and the lack of randomised trials, this meta-analysis suggests that endovascular TAAA repair could be a safer alternative to the open approach.
Randomized Prospective Trial of Epidural Analgesia after Open Hepatectomy
Authors: Arslan-Carlon Vittoria , Qadan Motaz , Puttanniah Vinay , Seier Kenneth , Gönen Mithat , Yang Gloria , Fischer Mary , DeMatteo Ronald P. , Kingham T. Peter , Jarnagin William R. , D’Angelica Michael I. 
Published: January 2024

Objective:
To evaluate whether patient-controlled epidural analgesia (PCEA) improves postoperative pain during ambulation following elective open hepatectomy.

Background:
Strategies to alleviate postoperative pain are a critical element of recovery after surgery. However, the optimal postoperative pain management strategy following open hepatectomy remains unclear.

Methods:
We conducted a prospective, non-blinded, randomized comparison of PCEA (intervention) vs. intravenous patient-controlled analgesia (IV PCA; control) for postoperative pain following elective open hepatectomy. The primary endpoint was pain during ambulation on postoperative day (POD) 2. The study was powered to detect a clinically significant 2-point difference on pain numeric rating scale (NRS). Secondary endpoints included pain at rest, morbidity, time to return of bowel function, and length of stay.

Results:
From 2015-2020, 231 patients were randomized (116 patients in the PCEA arm and 115 in the IV PCA arm). The incidence of epidural failure was 3% (n=4/116), with no epidural-related complications. Patients in the PCEA arm had a <2 point difference in NRS pain scores during ambulation on POD 2 vs. IV PCA (median 4.0 vs. 5.0, P<0.001). There was no difference in overall complications between the PCEA and IV PCA arms (33% vs. 40%, P=0.276). Secondary outcomes, including pain scores at rest, were similar between the study arms.

Conclusions:
PCEA was safe following open hepatectomy and was associated with a small difference in pain with activity on POD 2 that did not reach our pre-specified definition of clinical significance.
Psychometric Properties and Cutoff Value of the Turkish Overactive Bladder Symptom Score
Authors: Baran Emine , Gürşen Ceren , Ozgul Serap , Çinar Gamze Nalan , Nakip Gulbala , Üzelpasaci Esra , Ozgul Nejat , Beksaç Mehmet Sinan , Akbayrak Türkan 
Published: January 2024

Importance
The Overactive Bladder Symptom Score (OABSS) measures all overactive bladder (OAB) symptoms with graded answers, evaluates urgency symptoms, and reveals the subjective bladder control. However, the Turkish version and the cutoff value of the questionnaire have not yet been studied.

Objective
The aims of this study were to determine the psychometric properties of the 7-item OABSS and to estimate the cutoff value of the scale.

Study Design
This was an observational study. The internal consistency (Cronbach α) and test-retest reliability were analyzed, and exploratory factor analysis was performed. For the criterion validity, the correlations between the OABSS, the Overactive Bladder Questionnaire, the Bristol Female Lower Urinary Tract Symptoms questionnaire, and outcomes of a bladder diary were used. The cutoff value of the OABSS was analyzed by the receiver operating characteristics curve analysis.

Results
Participants with (n = 49) and without (n = 38) OAB were included. The internal consistency was very strong (Cronbach α = 0.95). The test-retest reliability was very strong (intraclass correlation coefficients = 0.93–0.95, P = 0.001). The percentage of explanation of the total variance was calculated as 78%. There was a strong to very strong correlation between the OABSS and the Overactive Bladder Questionnaire and Bristol Female Lower Urinary Tract Symptoms scores and outcomes of the bladder diary. The cutoff value for the OABSS was determined as 10.5.

Conclusions
The Turkish OABSS was found to be a valid and reliable scale to determine OAB symptoms and severity. Those who score more than 10.5 on the questionnaire can be considered as at risk of OAB syndrome.
Barbed Versus Nonbarbed Suture for Posterior Colporrhaphy: A Randomized Controlled Trial
Authors: Merriman Amanda L. , Burrell Aletheia D. , Winn Heather , Anderson William E. , Tarr Megan E. , Myers Erinn M. 
Published: January 2024

Importance
There is limited literature or even consensus on the suture material used for posterior vaginal repairs.

Objectives
This study aimed to compare outcomes of barbed versus nonbarbed delayed absorbable suture used for posterior colporrhaphy.

Study Design
This study conducted a randomized controlled trial of 72 women undergoing posterior repair using standardized technique—concurrent procedures permitted with barbed (n = 36) or nonbarbed (n = 36) suture. Standardized examinations, validated questionnaires, and a visual analog scale (VAS) were completed at baseline, 6 weeks, and 12 months, and a telephone interview was conducted at 6 months. The primary outcome was posterior compartment pain at 6 weeks, measured by a VAS.

Results
Seventy-two women enrolled, with follow-up rates 6 weeks (100%), 6 months (90.3%), and 12 months (73.6%). Demographics were similar between groups. A VAS with movement was not different between groups at 6 weeks. The odds of experiencing vaginal pain, having myofascial pain on examination, or being sexually active postoperatively were not different between the groups. There were no differences in the length of posterior colporrhaphy, surgical times, or hospital length of stay between the groups. Suture passes were lower in the nonbarbed group (median, 4 vs 7; P = <0.001), and suture burden was higher in the nonbarbed group (median, 26.9 vs 10.5 cm; P = <0.001). There was overall improvement in Pelvic Floor Distress Inventory Short Form 20 prolapse and colorectal subscores but no differences between groups. Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire Short Form 12 scores improved, and dyspareunia decreased at 6 and 12 months in both groups. In addition, there were few anatomic recurrences at 6 weeks (0%) and 12 months (3.4%) and few adverse events.

Conclusions
This study found no differences in primary or secondary outcomes; however, both suture types resulted in clinical improvements in quality-of-life measures and sexual function.
Association Between Maternal Depression and Lower Urinary Tract Symptoms in Their Primary School-Age Daughters
Authors: Cunningham Shayna D. , Lindberg Sarah , Joinson Carol , Shoham David , Chu Haitao , Newman Diane , Epperson Neill , Brubaker Linda , Low Lisa Kane , Camenga Deepa R. , LaCoursiere D. Yvette , Meister Melanie , Kenton Kimberly , Sutcliffe Siobhan , Markland Alayne D. , Gahagan Sheila , Coyne-Beasley Tamera , Berry Amanda 
Published: January 2024

PURPOSE:
Although maternal depression is associated with adverse outcomes in women and children, its relationship with lower urinary tract symptoms (LUTS) in offspring is less well-characterized. We examined the association between prenatal and postpartum maternal depression and LUTS in primary school-age daughters.

DESIGN:
Observational cohort study.

SUBJECTS AND SETTING:
The sample comprised 7148 mother-daughter dyads from the Avon Longitudinal Study of Parents and Children.

METHOD:
Mothers completed questionnaires about depressive symptoms at 18 and 32 weeks' gestation and 21 months postpartum and their children's LUTS (urinary urgency, nocturia, and daytime and nighttime wetting) at 6, 7, and 9 years of age. Multivariable logistic regression models were used to estimate the association between maternal depression and LUTS in daughters.

RESULTS:
Compared to daughters of mothers without depression, those born to mothers with prenatal and postpartum depression had higher odds of LUTS, including urinary urgency (adjusted odds ratio [aOR] range = 1.99-2.50) and nocturia (aOR range = 1.67-1.97) at 6, 7, and 9 years of age. Additionally, daughters born to mothers with prenatal and postpartum depression had higher odds of daytime wetting (aOR range = 1.81-1.99) and nighttime wetting (aOR range = 1.63-1.95) at 6 and 7 years of age. Less consistent associations were observed for depression limited to the prenatal or postpartum periods only.

CONCLUSIONS:
Exposure to maternal depression in the prenatal and postpartum periods was associated with an increased likelihood of LUTS in daughters. This association may be an important opportunity for childhood LUTS prevention. Prevention strategies should reflect an understanding of potential biological and environmental mechanisms through which maternal depression may influence childhood LUTS.
Evaluation of a Skin Barrier Ring With Assisted Flow
Authors: Colwell Janice C. , Pittman Joyce , Rider Paul , Purtill Helen , Duckworth Taylor 
Published: January 2024

PURPOSE:
The purpose of this study was to assess the effect of a skin barrier ring with assisted flow in preventing peristomal skin complications (PSCs) in patients with an ileostomy and to evaluate the participants' perceptions of the device.

DESIGN:
Single-group, prospective cohort study.

SUBJECTS AND SETTING:
Both inpatients and outpatients with newly created (n = 14) or established (n = 1) ileostomies were recruited from 2 clinical sites in the United States: one was an academic teaching hospital system in the Midwestern United States and the second was a teaching hospital located in the Southeastern United States.

METHODS:
Participants used the skin barrier ring with assisted flow after receiving education on its use. The pouching system was changed on a routine basis as determined by the ostomy nurse specialist. The Ostomy Skin Tool (OST) was used to assess each participant's peristomal discoloration (D), erosion (E), and tissue overgrowth (T) on admission to the study (baseline) and at final assessment (60 ± 33 days). Secondary outcomes (device handling, comfort, and discretion) were assessed through a questionnaire administered during the final data collection visit.

RESULTS:
The mean baseline DET score among the 14 participants with a new ileostomy was 2 or less, indicating no PSCs. The incidence of PSCs in this study was 40% (n = 6). Thirteen of 15 participants (86.7%) agreed that the skin barrier ring with assisted flow was easy to apply. Fourteen (93.4%) agreed that the device was comfortable and easy to remove. All 15 participants (100%) agreed it was discreet under clothing.

CONCLUSIONS:
Sixty percent of participants (n = 9) using the investigational device experienced a PSC. More than 90% of participants agreed that the device was comfortable and easy to remove, and all participants (100%) agreed it was discreet when worn under clothing.
Detecting Early-Stage Pressure Injury in Patients With Dark Skin Tones Using an Enhanced Physical Assessment Technique and Halogen Lighting
Authors: Waidley Monica , Taylor Nikki , Shever-Doletzky Leah L. 
Published: January 2024

PURPOSE:
The purpose of this quality improvement project was to identify stage 1 pressure injuries (PIs) in patients with darker skin tones using an enhanced skin assessment (Skin Assessment for Dark Skin, SADS) and halogen lighting.

PARTICIPANTS AND SETTING:
This quality improvement project was conducted on 3 units at a large university teaching hospital in Southeast Michigan. The project was originally designed so that participating patients were identified by bedside nurses as having sufficient melanin to obscure blanching on the hand/forearm using regular lighting, but this goal was not met. Data analysis is based on patients who self-identified as African American or Black, Native Hawaiian or Pacific Islander, Asian, American Indian, and Native Alaskan. Bedside nurses participating in this project were also asked to complete a questionnaire describing their knowledge and experiences with this project and assessment of early-stage PI in patients with darker skin tones.

APPROACH:
The Iowa Model of Evidence-Based Practice was used to guide this quality improvement initiative. Following a trigger event, we reviewed pertinent literature and developed an enhanced technique for assessing patients with darker skin tones that involved use of halogen lighting (SADS) and documentation of findings. We selected units from our facility and taught nurses to apply the SADS approach. Data from the electronic medical record and a survey of participating nurses were used to compare findings before and after project implementation. Comparisons were based on descriptive data analysis.

OUTCOMES:
Following implementation of the enhanced physical assessment, the participating units experienced a 6% decrease in the total number of facility-acquired PIs during the implementation period.

IMPLICATIONS FOR PRACTICE:
The enhanced physical assessment, when paired with halogen lighting, enhanced identification of stage 1 PI in persons with dark skin. The assessment method was easy to teach, learn, and can be performed at the bedside as part of a shift assessment which routinely includes inspection of skin.
Determinants of Bladder Care at Night in a Subacute Ward for Aged Patients
Authors: Brown Adelle , Ferguson Laura , Castillo Jasper , Nguyen Huong Xuan Thi , Ervin Claire , Whishaw David Michael , Bower Wendy 
Published: January 2024

PURPOSE:
The purpose of this study was to evaluate how bladder care at night correlates to patients' mobility status.

DESIGN:
This was an observational study.

SUBJECTS AND SETTING:
The sample comprises 63 aged care subacute patients who were observed over 3 consecutive nights in an inpatient subacute aged care ward located in Melbourne, Australia. Half of the participants were female; their mean age was 82.0 (standard deviation 8.2) years. Data were collected from December 2020 to March 2021.

METHODS:
Outcome variables included demographic and pertinent clinical characteristics, type and timing of toileting and/or bladder care provided, and mobility classification. Descriptive statistics were used to summarize the frequency of nocturnal bladder care provided each night and as a mean over the 3 nights. The relationship between the type of care units provided and other variables was explored using a 1-way analysis of variance; values ≤.05 were deemed statistically significant.

RESULTS:
Findings indicate that 27% (n = 17), 41% (n = 26), and 48% (n = 30) of participants required assistance to move in bed, sit up in bed, and stand from sitting, respectively. Care episodes for both incontinence and assistance with voiding were significantly associated with functional mobility in bed (F = 5.52, P < .001; F = 2.14, P = .02) and with ambulation independence (F = 3.52, P = .001; F = 2.04, P = .03) but not with age or ambulation distance.

CONCLUSIONS:
Care provided for urinary incontinence during the night was related to the need for physical support of ambulation and poor mobility in bed. Targeted input from a multidisciplinary team is warranted to facilitate change of practice at night.
Generative modeling of biological shapes and images using a probabilisticα-shape sampler
Authors: Winn-Nuñez Emily T. , Witt Hadley , Bhaskar Dhananjay , Huang Ryan Y. , Reichner Jonathan S. , Wong Ian Y. , Crawford Lorin 
Published: January 2024

AbstractUnderstanding morphological variation is an important task in many areas of computational biology. Recent studies have focused on developing computational tools for the task of sub-image selection which aims at identifying structural features that best describe the variation between classes of shapes. A major part in assessing the utility of these approaches is to demonstrate their performance on both simulated and real datasets. However, when creating a model for shape statistics, real data can be difficult to access and the sample sizes for these data are often small due to them being expensive to collect. Meanwhile, the current landscape of generative models for shapes has been mostly limited to approaches that use black-box inference—making it difficult to systematically assess the power and calibration of sub-image models. In this paper, we introduce theα-shape sampler: a probabilistic framework for generating realistic 2D and 3D shapes based on probability distributions which can be learned from real data. We demonstrate our framework using proof-of-concept examples and in two real applications in biology where we generate (i) 2D images of healthy and septic neutrophils and (ii) 3D computed tomography (CT) scans of primate mandibular molars. Theα-shape sampler R package is open-source and can be downloaded athttps://github.com/lcrawlab/ashapesampler.Author SummaryUsing shapes and images to understand genotypic and phenotypic variation has proven to be an effective strategy in many biological applications. Unfortunately, shape data can be expensive to collect and, as a result, sample sizes for analyses are often small. Despite methodological advancements in shape statistics and machine learning, benchmarking standards for evaluating new computational tools via data simulation is still underdeveloped. In this paper, we present a probability-based pipeline called theα-shape sampler which has the flexibility to generate new and unobserved shapes based on an input set of data. We extensively evaluate the generative capabilities of our pipeline using 2D cellular images of neutrophils and 3D mandibular molars from two different suborders of primates.
Pseudo-spectral angle mapping for automated pixel-level analysis of highly multiplexed tissue image data
Authors: Durkee Madeleine S. , Ai Junting , Casella Gabriel , Cao Thao , Chang Anthony , Halper-Stromberg Ariel , Jabri Bana , Clark Marcus R. , Giger Maryellen L. 
Published: January 2024

AbstractThe rapid development of highly multiplexed microscopy systems has enabled the study of cells embedded within their native tissue, which is providing exciting insights into the spatial features of human disease [1]. However, computational methods for analyzing these high-content images are still emerging, and there is a need for more robust and generalizable tools for evaluating the cellular constituents and underlying stroma captured by high-plex imaging [2]. To address this need, we have adapted spectral angle mapping – an algorithm used widely in hyperspectral image analysis – to compress the channel dimension of high-plex immunofluorescence images. As many high-plex immunofluorescence imaging experiments probe unique sets of protein markers, existing cell and pixel classification models do not typically generalize well. Pseudospectral angle mapping (pSAM) uses reference pseudospectra – or pixel vectors – to assign each pixel in an image a similarity score to several cell class reference vectors, which are defined by each unique staining panel. Here, we demonstrate that the class maps provided by pSAM can directly provide insight into the prevalence of each class defined by reference pseudospectra. In a dataset of high-plex images of colon biopsies from patients with gut autoimmune conditions, sixteen pSAM class representation maps were combined with instance segmentation of cells to provide cell class predictions. Finally, pSAM detected a diverse set of structure and immune cells when applied to a novel dataset of kidney biopsies imaged with a 43-marker panel. In summary, pSAM provides a powerful and readily generalizable method for evaluating high-plex immunofluorescence image data.Significance StatementUnderstanding the cellular constituents captured by highly multiplexed tissue imaging is a major limitation affecting the usability of these novel imaging methods. Many imaging experiments have uniquely designed staining panels, reducing the generalizability of cell classification models to new datasets. We present pseudospectral angle mapping (pSAM), which can compress high-dimensional image data into class representations. We demonstrate that the class representations generated by pSAM can be used to interpret high-plex image data and guide cell classification. Importantly, we also demonstrate that pSAM can generalize to new image datasets—collected with a different staining panel in samples from different tissues—without manual image annotation, subjective intensity gating, or re-training an algorithm.
Human Brain Mapping of Homotopic Functional Affinity
Authors: Chen Li-Zhen , Zuo Xi-Nian 
Published: January 2024

AbstractSpatially corresponding areas in the left and right hemispheres of the human brain, also known as homotopic brain regions, often exhibit functional similarities, i.e., functional homotopy. To understand the principles and mechanisms of functional homotopy in human psychological behavior, this paper proposes a method for studying functional homotopy in the human brain: homotopic functional affinity. This method quantifies the functional affinity of homotopic brain regions by calculating the cosine distance of whole-brain functional connectivity patterns of homotopic regions. Using the whole-brain functional MRI database from the Human Connectome Project in the United States and China, we first mapped the homotopic functional affinity atlas with “700 milliseconds - 2 millimeters” spatiotemporal precision, assessing its test-retest reliability for individual differences. Subsequently, we located three specific areas in the human temporo-parietal junction through systematic analysis of this atlas, discovering their hemispheric lateralization patterns and revealing their functional associations with attention, language, and social cognition. Lastly, through multimodal brain atlas correlation calculations, we further explored the correlation of human brain homotopic functional affinity with genetics, evolution, structural, and functional organizational distribution. In summary, our proposed method of homotopic functional affinity provides a reliable and valid functional measurement atlas for population neuroscience research.