bluuebunny/crossref_metadata_2025_split huggingface dataset:
Networked Radar Mission Planning Algorithm Based on Pulse Interleaving and Cross-Scheduling Interval
Authors: Luo Meng , Jiang Bing , Xing Wen-ge 
Published: December 2023

Abstract
Aiming at the problem of networked radar task planning, this paper proposes a task scheduling algorithm based on pulse interleaving and cross-scheduling interval from the perspective of rationally arranging communication and detection tasks, improving the utilization rate of radar system time resources and the success rate of task scheduling. The waiting period of tracking tasks is fully utilized to sort the tasks by pulse interleaving. On the other hand, taking advantage of the characteristics of large search task cycle and long timeliness, when there are still idle time slices in the current scheduling cycle that are not used, the time axis can be opened, and the subsequent scheduling interval can be The search tasks in the interval are advanced to be executed within the current scheduling cycle. The simulation results show that the algorithm can effectively improve the time resource utilization rate and task scheduling success rate of the system.
Permafrost degradation and soil erosion as drivers of greenhouse gas emissions from tundra ponds
Authors: Prėskienis Vilmantas , Fortier Daniel , Douglas Peter M J , Rautio Milla , Laurion Isabelle 
Published: December 2023

Abstract
Climate change poses a serious threat to permafrost integrity, with expected warmer winters and increased precipitation, both raising permafrost temperatures and active layer thickness. Under ice-rich conditions, this can lead to increased thermokarst activity and a consequential transfer of soil organic matter to tundra ponds. Although these ponds are known as hotspots for CO2 and CH4 emissions, the dominant carbon sources for the production of greenhouse gases (GHGs) are still poorly studied, leading to uncertainty about their positive feedback to climate warming. This study investigates the potential for lateral thermo-erosion to cause increased GHG emissions from small and shallow tundra ponds found in Arctic ice-wedge polygonal landscapes. Detailed mapping of fine-scale erosive features revealed their strong impact on pond limnological characteristics. In addition to increasing organic matter inputs, providing carbon to heterotrophic microorganisms responsible for GHG production, thermokarst soil erosion also increases shore instability and water turbidity, limiting the establishment of aquatic vegetation—conditions that greatly increase GHG emissions from these aquatic systems. Ponds with more than 40% of the shoreline affected by lateral erosion experienced significantly higher rates of GHG emissions (∼1200 mmol CO2 m−2 yr−1 and ∼250 mmol CH4 m−2 yr−1) compared to ponds with no active shore erosion (∼30 mmol m−2 yr−1 for both GHG). Although most GHGs emitted as CO2 and CH4 had a modern radiocarbon signature, source apportionment models implied an increased importance of terrestrial carbon being emitted from ponds with erosive shorelines. If primary producers are unable to overcome the limitations associated with permafrost disturbances, this contribution of older carbon stocks may become more significant with rising permafrost temperatures.
Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients
Authors: Alheraky Abdulrazzaq , Wierenga Albertus T J , Simpelaar Arjan , Hesp Lucy B , Minovic Isidor , Bagheri Niusha , Roozendaal Caroline , Span Lambert F R , Oude Elberink Hanneke N G , Kema Ido P , Mulder André B 
Published: December 2023

Abstract

Background
Hereditary alpha tryptasemia (HαT) has significant prevalence and potential morbidity in the general population. However, it remains largely undiagnosed in routine clinical diagnostics due to low availability of efficient assessment methods. To address this issue, we developed a reliable and efficient single-well multiplex digital droplet PCR assay.

Methods
The assay was based on the reconstruction of the TPSAB1 gene through quantification of the ratio of α- and β-tryptase copy number variants (CNV) in a single-well measurement. We performed analytical validation by determining CNV measurement clustering around the expected copy numbers in 281 cases and determined the diagnostic accuracy of basal serum tryptase (BST) to predict HαT and HαT subtypes in 141 symptomatic patients.

Results
The assay determined α- and β-tryptase CNVs with an overall accuracy, expressed as a 99% prediction interval, of 0.03 ± 0.27 copy numbers. The optimal BST cutoff level to predict HαT in symptomatic patients, who had no other explanation for relatively high tryptase levels (i.e., no diagnosis of systemic mastocytosis, myeloid neoplasm, or end-stage renal failure), was 9.2 ng/mL (sensitivity: 98.1%; specificity: 96.6%). HαT showed a linear gene–dose effect, with an average gene–dose increase of 7.5 ng/mL per extra α-tryptase gene.

Conclusion
Our single-well multiplex digital droplet PCR assay accurately determined HαT and could be implemented as a state-of-the-art routine diagnostic test. The assay demonstrated a strong correlation with BST and the optimal threshold for identifying HαT in symptomatic patients with unexplained high tryptase concentrations was at a BST level of 9.2 ng/mL.
Sign language usage of deaf or hard of hearing Sri Lankans
Authors: Udugama Leeljanaka S K , Nethsinghe Rohan , Southcott Jane , Kularathna Sampath , Dhanapala T D T Leslie , Alwis K Anoma C 
Published: December 2023

Abstract
In Sri Lanka, about 300,000 Sinhala speaking people are either deaf or hard of hearing (DHH) and would benefit from a common Sinhala sign language, technological resources such as captioning, and educational and social support. There is no fully developed common sign language for members of the Sinhalese community, a severe shortage of sign language interpreters, and few resources for teachers. This exploratory study was undertaken in all nine provinces of Sri Lanka into the use of sign language, access to education for people with disabilities, and the availability of trained or qualified educators to work with the DHH people. Data were gathered via interviews and focus groups with Special Education Assistant Directors, Principals and Teachers in Deaf Schools, and Teachers of Special Education Deaf Units in mainstream schools. The DHH members of Sri Lankan society are marginalized, under-supported, and require urgent attention to their educational and social needs. This study provides a basis for much needed attention and reform.
Effect of heat treatment and nitrogen atmosphere during post-curing on mechanical properties of 3D-printed orthodontic aligners
Authors: Mattle Mélanie , Zinelis Spiros , Polychronis Georgios , Makou Olga , Panayi Nearchos , Papageorgiou Spyridon N , Eliades Theodore 
Published: December 2023

Abstract

Objectives
Three-dimensional (3D)-printed aligners present a promising orthodontic treatment modality, whose clinical success largely depends on the material’s mechanical properties. The aim of this study was to evaluate the mechanical properties of resin-made 3D-printed aligners and assess the effect of two different post-curing conditions.

Materials and methods
Forty dumbbell-shaped specimens and 40 resin aligners were 3D-printed and divided into four equal groups according to post-curing conditions: presence or absence of oxygen during post-curing and water heat treatment at 85°C for 15 s or none. Samples from the central incisor of the aligner (n = 5/group) were studied by Attenuated Total Reflection Fourier-transform infrared spectroscopy (ATR-FTIR). The dumbbell-shaped specimens were loaded up to fracture under tensile mode and yield strength, ultimate tensile strength, elastic and plastic strain were calculated. The first mandibular molar area from 3D-printed aligners (n = 10/group) was cut and embedded in acrylic resin and then underwent metallographic grinding and polishing followed by instrumented indentation testing to determine the following mechanical properties: Martens hardness, indentation modulus, elastic index, and indentation relaxation. After descriptive statistics, differences according to each post-curing protocol, as well as their combination, were analyzed with linear regression modeling at a 5% significance level.

Results
All groups showed identical ATR-FTIR spectra, while no statistically significant effects were seen for either post-curing protocol (N2 presence and heat treatment) or their combination (P &gt; .05 in all instances).

Conclusions
The mechanical properties of 3D-printed resin aligners were not considerably affected either by post-curing in N2 atmosphere or heat treatment.
Long term peripheral AAV9-SMN gene therapy promotes survival in a mouse model of spinal muscular atrophy
Authors: Reilly Aoife , Yaworski Rebecca , Beauvais Ariane , Schneider Bernard L , Kothary Rashmi 
Published: December 2023

Abstract
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by motor neuron loss and skeletal muscle atrophy. SMA is caused by the loss of the SMN1 gene and low SMN protein levels. Current SMA therapies work by increasing SMN protein in the body. Although SMA is regarded as a motor neuron disorder, growing evidence shows that several peripheral organs contribute to SMA pathology. A gene therapy treatment, onasemnogene abeparvovec, is being explored in clinical trials via both systemic and central nervous system (CNS) specific delivery, but the ideal route of delivery as well as the long-term effectiveness is unclear. To investigate the impact of gene therapy long term, we assessed SMA mice at 6 months after treatment of either intravenous (IV) or intracerebroventricular (ICV) delivery of scAAV9-cba-SMN. Interestingly, we observed that SMN protein levels were restored in the peripheral tissues but not in the spinal cord at 6 months of age. However, ICV injections provided better motor neuron and motor function protection than IV injection, while IV-injected mice demonstrated better protection of neuromuscular junctions and muscle fiber size. Surprisingly, both delivery routes resulted in an equal rescue on survival, weight, and liver and pancreatic defects. These results demonstrate that continued peripheral AAV9-SMN gene therapy is beneficial for disease improvement even in the absence of SMN restoration in the spinal cord.
The burden and impact of COVID-19 among newborns in African countries: a study protocol for a systematic review and meta-analysis
Authors: Haile Teklehaimanot Gereziher , Getachew Tamirat , Negash Assefa Iyasu 
Published: December 2023

Abstract
The WHO, on 30 January 2020, declared the Chinese outbreak of coronavirus disease 2019 (COVID-19) a global community health emergency that poses a serious threat to vulnerable healthcare systems. This review protocol will be conducted to systematically review and to perform a meta-analysis on the impact of COVID-19 among newborns in Africa. All observational studies on the impact of COVID-19 among newborns in Africa will be included. A standard quest strategy to retrieve studies was conducted on several databases (Google Scholar, PubMed/MEDLINE, EMBASE, HINARI, Cochrane Library, WHO COVID-19 database, Africa Wide Knowledge and Web of Science). Two independent authors were tasked to extract key data and to assess the risk of bias. To assess possible publication bias, funnel plot test and Egger's test methods will be used. The description will be used to show the COVID-19 distribution data by interest variables such as residence, setting and person-level characteristics. The findings of this review will notify healthcare professionals about the burden and impact of COVID-19 and provide evidence to bring about the requisite improvements in clinical practice.
ExoMol line lists – LIV. Empirical line lists for AlH and AlD and experimental emission spectroscopy of AlD in A1Π (v = 0, 1, 2)
Authors: Yurchenko Sergei N , Szajna Wojciech , Hakalla Rafał , Semenov Mikhail , Sokolov Andrei , Tennyson Jonathan , Gamache Robert R , Pavlenko Yakiv , Schmidt Mirek R 
Published: December 2023

ABSTRACT
New ExoMol line lists AloHa for aluminium hydride (AlH and AlD) are presented improving the previous line lists WYLLoT. The revision is motivated by the recent experimental measurements and astrophysical findings involving the highly excited rotational states of AlH in its A 1Π − X 1Σ+ system. A new high-resolution emission spectrum of 10 bands from the A 1Π − X 1Σ+ system of AlD, in the region 17 300–32 000 cm−1 was recorded with a Fourier transform spectrometer, which probes the predissociative A 1Π v = 2 state. The AlD new line positions are combined with all available experimental data on AlH and AlD to construct a comprehensive set of empirical rovibronic energies of AlH and AlD covering the X 1Σ+ and A 1Π electronic states using the MARVEL approach. We then refine the spectroscopic model WYLLoT to our experimentally derived energies using the nuclear-motion code Duo and use this fit to produce improved line lists for 27AlH, 27AlD, and 26AlH with a better coverage of the rotationally excited states of A 1Π in the predissociative energy region. The lifetimes of the predissociative states are estimated and are included in the line list using the new ExoMol data structure, alongside the temperature-dependent continuum contribution to the photoabsorption spectra of AlH. The new line lists are shown to reproduce the experimental spectra of both AlH and AlD well, and to describe the AlH absorption in the recently reported Proxima Cen spectrum, including the strong predissociative line broadening. The line lists are included into the ExoMol data base www.exomol.com.
Priorities in research portfolios: exploring the need for upstream research in cardiometabolic and mental health
Authors: van de Klippe Wouter , Yegros-Yegros Alfredo , Willemse Tim , Rafols Ismael 
Published: December 2023

Abstract
A current issue in mission-oriented research policy is the balance of priorities in research portfolios. In parallel, in health policies, there is a debate on shifting research away from biomedical treatments towards health promotion and well-being. In this study, we examine if research agendas are responsive to these demands in cardiometabolic and mental health. First, we conducted bibliometric analyses which showed that most research remains focused on biomedical and clinical approaches. In contrast, focus groups and interviews suggested that more research is needed upstream, i.e. on broader determinants of health, public health, and health systems. Most experts also saw a need for more intervention-oriented research. Furthermore, comparisons between cardiometabolic and mental health suggested that they require similar upstream knowledge in issues such as health systems, nutrition, labour, or economic conditions. We discuss the reasons for the persistence of current priorities and the implications in the context of funding strategies.
Clinical characteristics of snakebite patients attending a tertiary hospital in Hangzhou, southeast China
Authors: Shen Yuchen , Hu Sipin , Bao Shuhua , Tu Mengyun 
Published: December 2023

Abstract

Background
Venomous snakebite is a neglected yet an important public health problem in China, and few studies have focused on them so far. The aim of this study is to investigate clinical characteristics of snakebites patients in a tertiary hospital in Hangzhou, southeast China.

Methods
A total of 416 snakebite cases were included in this retrospective study. The data were collected from the medical records including demographics, clinical manifestations, management and outcomes.

Results
Of the 416 patients with venomous snakebites, 248 were male, and the average age was 54.6 years. The majority of cases occurred in rural in May to September. Out of all the venomous bites, Gloydius brevicaudus accounted for the highest percentage (55.3%). Hands were the most vulnerable site to snakebites (47.4%). Patients had clinical manifestations of pain (100%), swelling (100%), wound necrosis (25.7%), hemorrhagic blister (18.3%), and blister (8.7%). Three hundred and ninety-two patients received antivenom administration, and most were treated within six hours after bites. Twenty-six patients received surgical treatments, and 90 patients developed venom-induced consumption coagulopathy. No deaths have occurred in this study.

Conclusion
Hangzhou is one of the regions with high affecting of snakebites in China. The results of this study will increase the understanding of the clinical characteristics of venomous snakebites in Hangzhou area.
Salt restriction for treatment of hypertension – current state and future directions
Authors: Nolan Philip , McEvoy John W. 
Published: December 2023

Purpose of review
Given the adverse effects of excess dietary sodium chloride (also known as table salt) on blood pressure (BP) and cardiovascular disease (CVD), restriction of dietary sodium is recommended by numerous guidelines. The strictest of these recommend no more than 1.5 g/day of dietary sodium among hypertensive persons. However, average dietary sodium intake in the population is closer to 5 g/day and there is debate about whether too much sodium restriction may be associated with increased CVD risk. Herein, we aim to provide a balanced update on this topic.

Recent findings
In 2021, the Salt Substitute and Stroke Study (SSaSS) demonstrated a significant reduction in BP, CVD, and death among Chinese adults randomized to a low sodium salt-substitute supplemented with potassium. This trial largely puts to rest any remaining debate about the benefits of dietary sodium restriction among persons with excess baseline intake (dietary sodium intake fell from approximately 5 down to 4 g/day in the active arm of SSaSS). However, whether achieving and maintaining a dietary sodium of less than1.5 g/day is feasible in real-world settings and whether this low an intake is harmful remain open questions.

Summary
Aiming for sodium intakes of 2--3 g/day in the general population and as low as 2 g/day in persons with hypertension or CVD seems most reasonable, but there is some uncertainty around lower targets.
Prognostic value of para-aortic lymph node metastasis and dissection for pancreatic head ductal adenocarcinoma: a retrospective cohort study
Authors: Xu Yecheng , Yang Feng , Fu Deliang 
Published: December 2023

Background:
Para-aortic lymph node (PALN) metastasis affects approximately 20% of patients with pancreatic ductal adenocarcinoma (PDAC). However, the prognostic significance of PALN metastases and dissection remains unclear.

Methods:
This retrospective cohort study included patients with PDAC of the pancreatic head who had undergone pancreaticoduodenectomy (PD) at our center between January 2017 and December 2020.

Results:
A total of 234 patients were included in the study. PALN dissection improved the median overall survival (OS) without statistical significance (24.1 vs 18.1 months, P = .156). The median recurrence-free survival was significantly longer in the PALN-dissection group than the group without PALN dissection (18.2 vs 11.6 months, P = .040). Conversely, there were no significant differences in the long-term prognosis between the PALN-positive and PALN-negative subgroups in the PALN-dissection group. Multivariate analysis showed that PALN metastasis was not an independent risk factor for OS (hazard ratio: 0.831, 95% confidence interval: 0.538–1.285, P = .406).

Conclusions:
For patients with pancreatic head ductal adenocarcinoma, PD with PALN dissection may achieve survival prolongation and bridge the survival gap between patients with and without PALN metastasis without significantly increasing the perioperative risks.
Diagnosis and management of acute lower gastrointestinal bleeding
Authors: Elimeleh Yotam , Gralnek Ian M. 
Published: December 2023

Purpose of review
We review and summarize the most recent literature, including evidence-based guidelines, on the evaluation and management of acute lower gastrointestinal bleeding (LGIB).

Recent findings
LGIB primarily presents in the elderly, often on the background of comorbidities, and constitutes a significant healthcare and economic burden worldwide. Therefore, acute LGIB requires rapid evaluation, informed decision-making, and evidence-based management decisions. LGIB management involves withholding and possibly reversing precipitating medications and concurrently addressing risk factors, with definitive diagnosis and therapy for the source of bleeding usually performed by endoscopic or radiological means. Recent advancements in LGIB diagnosis and management, including risk stratification tools and novel endoscopic therapeutic techniques have improved LGIB management and patient outcomes. In recent years, the various society guidelines on acute lower gastrointestinal bleeding have been revised and updated accordingly.

Summary
By integrating the most recently published high-quality clinical studies and society guidelines, we provide clinicians with an up-to-date and comprehensive overview on acute LGIB diagnosis and management.
Neonatal sepsis and its predictors in Ethiopia: umbrella reviews of a systematic review and meta-analysis, 2023
Authors: Eyeberu Addis , Musa Ibsa , Debella Adera 
Published: December 2023

Background:Although neonatal sepsis is acknowledged as the primary cause of newborn death in Ethiopia, data on its impact at the national level are limited. Strong supporting data are required to demonstrate how this affects neonatal health. This umbrella study was conducted to determine the overall prevalence of newborn sepsis and its relationship with maternal and neonatal factors.Methods:This umbrella review included five articles from various databases. The AMSTAR-2 method was used to assess the quality of included systematic review and meta-analysis studies. STATA Version 18 software was used for statistical analysis. A random-effects model was used to estimate the overall effects.Results:In this umbrella review, 9032 neonates with an outcome of interest were included. The overall pooled prevalence of neonatal sepsis was 45% (95% CI: 39–51%; I2=99.34). The overall pooled effect size showed that prematurity was significantly associated with neonatal sepsis [odds ratio=3.11 (95% CI: 2.22–3.99)]. Furthermore, maternal factors are strongly associated with neonatal sepsis.Conclusions:Nearly half of Ethiopian neonates are affected by neonatal sepsis. It is critical to reduce premature birth, low birth weight, and preterm membrane rupture to reduce the incidence of neonatal sepsis. Furthermore, it is preferable to design and strengthen policies and programs aimed at improving maternal nutritional status and treating maternal infections, which all contribute to lowering the burden of neonatal sepsis.