bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coding Variants of the Genitourinary Development Gene
WNT9B
Carry High Risk for Prostate Cancer
Authors: Dupont William D. , Jones Angela L. ,   VA Million Veteran Program, Smith Jeffrey R. 
Published: January 2025

PURPOSE
Considerable genetic heterogeneity is currently thought to underlie hereditary prostate cancer (HPC). Most families meeting criteria for HPC cannot be attributed to currently known pathogenic variants.

METHODS
To discover pathogenic variants predisposing to prostate cancer, we conducted a familial case-control association study using both genome-wide single-allele and identity-by-descent analytic approaches. Sequence of high-risk haplotype carriers was used for variant detection. Candidate pathogenic variants were tested for association with prostate cancer across independent biobanks for replication of observations.

RESULTS

Pathogenic variants within
WNT9B
were associated with familial prostate cancer and observations replicated within four of four independent biobanks.
WNT9B
E152K carried 2.5-fold risk and reached genome-wide significance under meta-analysis, collectively encompassing a half million patients.
WNT9B
Q47R was also associated with prostate cancer with genome-wide significance among Finns, for which identity-by-descent analyses confirmed a founder effect.
WNT9B
shares an unexpected commonality with the previously established prostate cancer risk genes
HOXB13
and
HNF1B
: they are each required for embryonic prostate development. With this recognition, we further evaluated two additional genes known to cause Mendelian genitourinary developmental defects,
KMT2D
and
DHCR7
. These too were nominally associated with prostate cancer under meta-analyses.

CONCLUSION

WNT9B
and additional genes that are required for early genitourinary development are also involved in the later development of prostate cancer.
Glucose Metabolic Abnormalities and Their Interaction With Defective Phosphate Homeostasis in Tumor-induced Osteomalacia
Authors: Zhou RuoTong , Jiajue Ruizhi , Ni Xiaolin , Pang Qianqian , Chi Yue , Jiang Yan , Wang Ou , Li Mei , Xing Xiaoping , Cui Lijia , Li Xiang , Liu Yong , Wu Huanwen , Jin Jin , Lv Wei , Xia Yu , Huo Li , Zhou Lian , Yu Wei , Meng XunWu , Xia Weibo 
Published: January 2025

Abstract

Context
Phosphate homeostasis was compromised in tumor-induced osteomalacia (TIO) due to increased fibroblast growth factor 23 (FGF23) secretion. Nevertheless, the glucose metabolic profile in TIO patients has not been investigated.

Objectives
This work aimed to clarify the glucose metabolic profiles in TIO patients and explore their interaction with impaired phosphate homeostasis.

Methods
20 TIO patients, 20 individuals with normal glucose tolerance, and 20 patients with type 2 diabetes mellitus (DM) were enrolled and underwent an oral glucose tolerance test (OGTT). Serum phosphate and FGF23 concentration were monitored during OGTT.

Results
In patients with TIO, 60% (12/20) exhibited impaired glucose tolerance (IGT) and 5% (1/20) had type 2 DM. Those with IGT or type 2 DM experienced more ambulatory difficulties (69.2% vs 42.9%), lower phosphate concentrations (0.43 ± 0.10 vs 0.53 ± 0.10, P = .042), and lower calcium concentrations (2.20 ± 0.08 vs 2.30 ± 0.40, P = .001) compared to TIO patients without these conditions. According to correlation analysis, serum phosphate levels were negatively correlated with plasma glucose levels at 60 minutes (P &lt; .001), fasting plasma insulin levels (P &lt; .05), and homeostasis model assessment for insulin resistance (P &lt; .05). Those with high FGF23 levels had a higher glucose level at 60 minutes (10.5 [9.3, 12.3] vs 7.3 [6.4, 10.1], P = .048) than that of low group. After glucose loading, both FGF23 and phosphate levels exhibited a decreasing trend.

Conclusion
The development of diabetes in TIO patients may be predisposed by ambulatory issues, low phosphate, and elevated FGF23 levels. Dysglycemia might further aggravate hypophosphatemia.
Diagnostic Value of 11C-Methionine PET-CT Imaging in Persistent or Recurrent Cushing Disease After Surgery
Authors: Furnica Raluca Maria , Devuyst France , Mathey Céline , Constantinescu Stefan Matei , De Herdt Carlien , Alexopoulou Orsalia , Lhommel Renaud , Maiter Dominique 
Published: January 2025

Abstract

Context
Equivocal or negative pituitary magnetic resonance imaging (MRI) findings pose a significant challenge in the management of persistent or recurrent Cushing disease (CD), compromising the chances of success of further transsphenoidal surgery (TSS).

Objective
To determine the diagnostic utility of 11C-methionine (11C-MET) positron emission tomography/computerized tomography (PET/CT) in localizing residual or relapsing corticotroph adenoma.

Methods
We retrospectively analyzed the results of all 11C-MET PET/CT performed at 2 tertiary medical centers between May 2002 and November 2023 in 22 patients with persistent/recurrent CD after initial TSS and equivocal/negative pituitary MRI. In 15 cases, 11C-MET PET/CT images were also co-registered with high-resolution 3D T1 or FLAIR MRI pituitary imaging.

Results
Of 22 patients (18 female; mean age 36 years at diagnosis; mean initial tumor maximum diameter 6.5 mm), 13 had a suspect anomaly on conventional MRI and 9 had a negative MRI. Maximal metabolic activity in the suspect area (SUVmaxT) was found in 14 patients (63.5%; 5/9 patients with negative pituitary MRI and 9/13 with equivocal findings). Based on positive imaging, 12 patients underwent repeat TSS, successful in 7, while 2 patients underwent Gamma Knife radiosurgery (GKRS), both resulting in remission (total remission rate of 64%). Among the 5 patients not cured by TSS, the presence of corticotroph adenoma in the resected tissue was found in 3 cases. Positive 11C-MET PET/CT had a detection rate accuracy of 86% (12/14). Of the 8 PET-negative patients, 2 underwent exploratory TSS, with no remission, and 2 underwent GKRS, with 1 long-term remission.

Conclusion
11C-MET PET/CT imaging can provide valuable diagnostic information to detect a corticotroph microadenoma in more than half of patients with persistent/recurrent CD and equivocal or negative MRI findings, allowing targeted TSS or radiosurgery with a global success rate of 64% in the selected subgroup with positive imaging.
Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours
Authors: Nicheperovich Alina , Schuster-Böckler Benjamin , Ní Leathlobhair Máire 
Published: January 2025

ABSTRACT
Gestational trophoblastic disease (GTD) describes a group of rare benign and cancerous lesions originating from the trophoblast cells of the placenta. These neoplasms are unconventional entities, being one of the few instances in which cancer develops from the cells of another organism, the foetus. Although this condition was first described over 100 years ago, the specific genetic and non-genetic drivers of this disease remain unknown to this day. However, recent findings have provided valuable insights into the potential mechanisms underlying this rare condition. Unlike previous reviews focused primarily on the clinical and diagnostic aspects of disease development, this Review consolidates the latest research concerning the role of genetics, epigenetics and microRNAs in the initiation and progression of GTD. By examining GTD from a molecular perspective, this Review provides a unique framework for understanding the pathogenesis and progression of this rare disease.
Preschool teachers’ views about preschool death education: The role of perceived self-efficacy, perceived competence and death experiences
Authors: Brouskeli Vasiliki , Piperkou Ioanna- Konstantina 
Published: January 2025

Preschool educators’ views about preschool death education is researched in this paper. Specifically, we examined preschool educators’ personal perspectives on providing death education in relation to: a) their intra-personal characteristics, such as perceived self-efficacy and perceived professional competence to provide this kind of education, and b) their death experiences in the school environment. The sample consisted of 164 preschool teachers in Greek public schools. Perceived self-efficacy was found to be related to teachers’ perceived competence in dealing with death issues. However, no significant relationship was found between self-efficacy and teachers’ actual dealing with the topic. Death experiences in the school environment were found to relate positively to teachers’ perceived competence in providing death education. However, no significant relationship was found between these experiences and the level of dealing with the topic. The results indicate that preschool teachers realize the need for death education. However, this is difficult to become actual behavior, since they lack proper preparation. Educators need not only theoretical knowledge but a holistic preparation program that would ensure that they will be able to stand in front of preschoolers with sufficient knowledge, continuous training, increased self-efficacy, and perceived competence in order to be able to provide developmentally appropriate education.
A Review of the Health Impact of Nicotine Pouches
Authors: Chmiel Radosław , Michałka Daria , Papachristoforou Natalie , Gałuszka Zuzanna , Makar Monika , Bartuś Tomasz , Tekiela Natalia , Bąk Emilia , Głowacka Justyna , Kocjan Aleksandra 
Published: January 2025

Introduction and Purpose of Research
Nicotine pouches, popular especially among young people, are smokeless alternatives to traditional tobacco. Placed in the mouth, they release nicotine absorbed through the mucosa, reducing withdrawal symptoms and avoiding harmful tobacco smoke. Often used for smoking cessation, they are considered lower-risk than smoking and may help reduce smoking rates. The aim of this review is to summarize the current knowledge on the impact of nicotine pouches on overall human health.

Review Methods
The review is based on 39 articles found in PubMed databases published between 2006–2024.
Conclusion
While nicotine pouches and snus are marketed as lower-risk alternatives to smoking, their health implications are still significant. These products, popular among young adults and athletes, may help with smoking cessation but carry risks, particularly with long-term use. Research suggests nicotine pouches and snus may have no performance-enhancing effects in sports and could impair physical performance, including endurance and strength. Moreover, their use is linked to various health concerns such as cardiovascular issues, type 2 diabetes, oral mucosal changes, and decreased sperm count. Snus has been associated with a modest increase in cardiovascular disease risk, although the risks are lower than smoking. Additionally, smokeless tobacco use is linked to an increased risk of oral squamous cell carcinoma, especially in women. The use of snus during pregnancy has also been linked to higher risks of post-neonatal mortality and other adverse outcomes. Despite these findings, there is a need for more extensive, well-controlled studies to fully understand the long-term health effects of smokeless tobacco products and their role in public health.
SISTEMA DE MOBILIZAÇÃO NACIONAL FRENTE UMA AMEAÇA EXTERNA E A SEGURANÇA ENERGÉTICA (MARÍTIMA)
Authors: Costa Mannom Tavares , Góes Guilherme Sandoval 
Published: January 2025

RESUMO:Este artigo pretende abordar um paradoxo do Poder Marítimo Brasileiro frente uma ameaça externa para manutenção do perfil energético nacional, no estudo de caso relacionado às infraestruturas críticas de exploração de hidrocarbonetos, em específico no que tange as plataformas de petróleo e os ativos humanos embarcados ao ser decretado o Sistema Nacional de Mobilização. O problema de pesquisa é se o Estado consegue manter o perfil energético brasileiro oriundo dos poços petrolíferos marítimos em operação ao ser decretado o SINAMOB frente uma ameaça externa, com recursos humanos mobilizáveis pela legislação. Os objetivos: (1) geral: é afeto à Segurança Energética pelo Poder Marítimo frente uma ameaça externa e (2) secundários: estão vinculados com as Política Marítima Nacional (PMN), Política de Mobilização Nacional. Palavras-chave: Segurança Energética. Governança. Poder marítimo. Ativo Humano Embarcado. Marinha Mercante.
Factors influencing medication adherence among hypertensive patients in primary care settings in Central Vietnam: A cross-sectional study
Authors: Anh Hien Ho , Tam Nguyen Minh , Van Minh Huynh , Binh Thang Tran , Phuoc Hoang Le , Heytens Stefan , Devroey Dirk , Anh Tien Hoang 
Published: January 2025

Background
Medication adherence plays a crucial role in effectively managing hypertension, a significant public health concern, especially in regions like Central Vietnam. This study aimed to assess medication adherence levels among hypertensive patients in primary care settings and explore the factors influencing adherence within this specific population.

Methods
We conducted a cross-sectional study to evaluate medication adherence and its determinants among individuals with hypertension in Central Vietnam. Medication adherence was assessed using the 5-item version of the Medication Adherence Report Scale self-report. We collected data on the demographics, medical history, lifestyle, hypertension knowledge, along with the patient beliefs and perceptions about hypertension. Logistic regression analysis was employed to identify the key factors associated with their medication adherence.

Results
Our study revealed that only half of the hypertensive patients adhered to their prescribed medication regimens. Several factors significantly influenced their medication adherence, including age, ethnicity, educational level, home blood pressure monitoring, healthy diet, time since hypertension diagnosis, hypertension knowledge, and patient beliefs. According to the logistic regression analysis, a healthy diet and patient beliefs emerged as primary predictors of medication adherence. Patients who strongly believed in the necessity of medication demonstrated better adherence, while concerns about overuse and harm were linked to lower adherence levels.

Conclusions
This study highlighted the suboptimal levels of medication adherence among hypertensive patients in primary care settings in Central Vietnam. It underscored the urgent need for tailored interventions to address this issue. For the sake of better medication adherence, healthcare providers were suggested to prioritize patient education, address patient beliefs and concerns about medication, and promote the practice of home blood pressure monitoring.
A narratív tér mint a figyelmi háttér eleme Móricz Zsigmond "Tragédia" című novellájában
Authors: Szabó Erzsébet 
Published: January 2025

A klasszikus narratológiai elképzelések és a kognitív poétikák megegyeznek abban, hogy a narratív térnek a cselekményhez képest másodlagos szerepet tulajdonítanak. A jelen tanulmány a narratív tér ezen másodlagos szerepét vizsgálja narratív szövegek olvasásakor. A figyelmi folyamatok kognitív pszichológiai modelljéből, valamint Roland Barthes a narratív művek struktúrájára, azon belül az ún. indexikális jelekre vonatkozó állításaiból kiindulva a kognitív nyelvészet és a kognitív poétika kutatási eredményei alapján amellett érvel, hogy a narratív tér másodlagos szerepe a figyelmi szelekciót támogató funkciójából és a nyelv alapvető metaforikusságából következik. A tanulmány eredményeit Móricz Zsigmond Tragédia című novellájának példáján mutatom be.
Doping TiO2 with Cu from electroplating wastewater for remarkable improvement of its activity under visible light for E. coli bacterial disinfection in water
Authors: Wahyuni Endang T. , Suwondo Kusuma P. , Pratista Eka , Rani Jeannina C. , Avrillostya Andrew , Aprilita Nurul H. , Sulistyani Eko T. , Jaafar Nur F. 
Published: January 2025

Abstract
This study investigates the feasibility of use electroplating wastewater as a source of copper (Cu) dopants to improve the photocatalytic efficacy of TiO2 under visible light for the disinfection of water contaminated with Escherichia coli. The Cu-doped TiO2 was produced by the sol-gel process, employing titanium tetra-isopropoxide (TTIP) and Cu(II) ions derived from wastewater. By modifying the concentration of Cu(II), TiO2-Cu photocatalysts with differing copper concentrations were synthesized. The doping procedure substantially decreased the band gap of TiO2, facilitating activation under visible light and markedly enhancing its photocatalytic efficacy. The ideal Cu doping concentration was determined to be 0.60 %, which decreased the band gap from 3.20 eV (pure TiO2) to 2.88 eV. Under visible light, the TiO2-Cu (0.60 %) photocatalyst attained a remarkable 98.21 % reduction of E. coli after 30 min, in contrast to a mere 38.42 % reduction by undoped TiO2. This study emphasizes the feasibility of using industrial wastewater to develop economical and effective TiO2 photocatalysts for water purification purposes.
О ВОСПРОИЗВОДСТВЕ ЛЕСОВ В КРАСНОЯРСКОМ КРАЕ
Authors: ОНУЧИН А.А. , СОКОЛОВ В.А. , ВТЮРИНА О.П. 
Published: January 2025

За последние два десятилетия ежегодно в Сибири вырубалось около 600 тыс. га лесов, примерно столько же уничтожалось лесными пожарами, а также повреждалось вредителями леса (сибирским шелкопрядом - Dendrolimus sibiricus Tschetverikov, полиграфом уссурийским - Polygraphus proximus Blandford и др.), а также ветровалами и промышленными эмиссиями. Сложные изменения в лесном покрове свидетельствуют об ухудшении качественного состава лесов. Причины этого - не глобальное потепление климата, а и вполне предсказуемые антропогенные и природные факторы: рубки леса, пожары и очаги вредителей леса, естественные возобновительные процессы, отчуждения вследствие развития инфраструктуры. Лесное хозяйство России пока далеко от решения проблемы полноценного воспроизводства лесов. Устранение негативных явлений может быть достигнуто посредством последующих лесохозяйственных мероприятий, включающих рубки ухода, охрану и защиту леса. Длительный период воспроизводства в лесном хозяйстве диктует необходимость принятия решений, результаты которых будут проявляться много десятилетий спустя. Система действий должна быть нацелена на адаптацию лесов к прогнозируемым природным и экономическим изменениям.
On average, in Siberia about 600 thousand hectares of forests have been annually cut down in the last two decades and about the same much damage from forest fires. Furthermore, forest stands have been damaged by pests (Siberian silkworm ( Dendrolimus sibiricus Tschetverikov), four-eyed fir bark beetle ( Polygraphus proximus Blandford), etc.) as well as windfalls and industrial emissions. Forest cover significant changes indicate the need identifying the causes of those changes for the purpose of eliminating negative phenomena. The forest fund dynamics disclose a deterioration of the qualitative species composition. The reasons for this are not only global climate warming, but and quite predictable human and natural factors: logging, forest fires, forest insect outbreaks, natural forest regeneration processes, and forest land transfers for infrastructure development. Forestry in Russia is still far from solving the problem of full-fledged forest reproduction. Forest reproduction involves a number of stages that must be consistently implemented to achieve the final goal. Reproduction of forest resources is preceded by the process of reforestation, which involves the restoration of cut, dead or damaged forests and which ensures the formation of a closed young forest, but does not guarantee the necessary structure and target functions of a mature forest. The latter can be achieved through subsequent forestry measures, including thinning, forest protection and conservation. The long period of forest regeneration calls for the need for decision-making, which results will be achieved in many decades later. The action system should be aimed at adapting forests to predicted natural and economic transformations.
К ОЦЕНКЕ ЭФФЕКТИВНОСТИ УПРАВЛЕНИЯ СИСТЕМОЙ ПОСТАВОК ТОВАРНОЙ ДРЕВЕСИНЫ
Authors: ЕНАЛЕЕВА-БАНДУРА И.М. , БАРАНОВ А.Н. , БРОВКИН С.А. , ГРИГОРЬЕВ И.В. , КОВАЛЕВ Р.Н. 
Published: January 2025

Проанализированы и актуализированы особенности процессов функционирования транспортно-технологической системы поставок товарной древесины и ее управления, а также основные параметры оптимизации системы управления цепями поставок товарной древесины для обеспечения эффективности процесса. Предложен многокритериальный подход к оценке эффективности функционирования транспортно-технологического процесса поставок товарной древесины и разработана ее математическая модель, основанная на методах линейного и динамического программирования, стохастического и экономико-математического моделирования, элементах статистического и экономического анализа. Совокупность отмеченных методов моделирования позволяет модели быть достаточно простой и надежной в практическом применении, а также адаптивной к изменяющимся внешним условиям производственной среды. Разработка представлена подробным описанием всех входящих в нее зависимостей, отмечены преимущества ее применения.
The article analyzes and updates the features of the functioning of the transport and technological system for the supply of commercial wood and supply chain management, and identifies the main parameters for optimizing the supply chain management system for commercial wood to ensure the efficiency of the process. A multi-criteria approach to assessing the efficiency of the transport and technological process of supplying commercial timber is proposed due to the inconsistency of the main indicators that determine its effectiveness. A mathematical model has been developed for a complex multi-criteria assessment of the efficiency of the transport and technological process of supplying commercial wood, based on: methods of linear and dynamic programming, stochastic and economic-mathematical modeling, elements of statistical and economic analysis. The combination of the mentioned modeling methods allows the model to be quite simple and reliable in practical application, as well as adaptive to the changing external conditions of the production environment. The methodological development is presented with a detailed description of all the dependencies included in it, and the advantages of its application are noted.