bluuebunny/crossref_metadata_2025_split huggingface dataset:
VaginalLactobacillusfatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment
Authors: Zhu Meilin , Frank Matthew W. , Radka Christopher D. , Jeanfavre Sarah , Tse Megan W. , Pacheco Julian Avila , Pierce Kerry , Deik Amy , Xu Jiawu , Hussain Salina , Hussain Fatima Aysha , Xulu Nondumiso , Khan Nasreen , Pillay Vanessa , Dong Krista L. , Ndung’u Thumbi , Clish Clary B. , Rock Charles O. , Blainey Paul C. , Bloom Seth M. , Kwon Douglas S. 
Published: December 2023

AbstractBacterial vaginosis (BV), a common syndrome characterized byLactobacillus-deficient vaginal microbiota, is associated with adverse health outcomes. BV often recurs after standard antibiotic therapy in part because antibiotics promote microbiota dominance byLactobacillus inersinstead ofLactobacillus crispatus, which has more beneficial health associations. Strategies to promoteL. crispatusand inhibitL. inersare thus needed. We show that oleic acid (OA) and similar long-chain fatty acids simultaneously inhibitL. inersand enhanceL. crispatusgrowth. These phenotypes require OA-inducible genes conserved inL. crispatusand related species, including an oleate hydratase (ohyA) and putative fatty acid efflux pump (farE). FarE mediates OA resistance, while OhyA is robustly active in the human vaginal microbiota and sequesters OA in a derivative form that onlyohyA-harboring organisms can exploit. Finally, OA promotesL. crispatusdominance more effectively than antibiotics in anin vitromodel of BV, suggesting a novel approach for treatment.
Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response
Authors: Mazunina Elena P. , Gushchin Vladimir A. , Kleymenov Denis A. , Sinyavin Andrey E. , Burtseva Elena I. , Shmarov Maksim M. , Mukasheva Evgenya A. , Bykonia Evgeniia N. , Kozlova Sofia R. , Evgrafova Elina A. , Zolotar Anastasia N. , Shidlovskaya Elena V , Kirillova Elena S. , Krepkaia Anastasiya S. , Usachev Evgeny V. , Kuznetsova Nadezhda A. , Ivanov Igor A. , Dmitriev Sergey E. , Ivanov Roman A. , Logunov Denis Y. , Gintsburg Alexander L. 
Published: December 2023

ABSTRACTSeasonal influenza remains a serious global health problem, leading to high mortality rates among the elderly and individuals with comorbidities. It also imposes a substantial economic burden through increased absenteeism during periods of active pathogen circulation. Vaccination is generally accepted as the most effective strategy for influenza prevention. As both influenza A and B viruses circulate and cause seasonal epidemics, vaccines need to include multiple antigens derived from different viral subtypes. While current influenza vaccines are effective, they still have limitations, including narrow specificity for certain serological variants, which may result in a mismatch between vaccine antigens and circulating strains. Additionally, the rapid variability of the virus poses challenges in providing extended protection beyond a single season. Therefore, mRNA technology is particularly promising for influenza prevention, as it enables the rapid development of multivalent vaccines and allows for quick updates of their antigenic composition. mRNA vaccines have already proven successful in preventing COVID-19 by eliciting rapid cellular and humoral immune responses. In this study, we present the development of a trivalent mRNA vaccine candidates, evaluate its immunogenicity using the hemagglutination inhibition assay, and assess its efficacy in animals. We demonstrate the higher immunogenicity of the mRNA vaccine candidates compared to the inactivated split influenza vaccine and its enhanced ability to generate a cross-specific humoral immune response. These findings highlight the potential mRNA technology in overcoming current limitations of influenza vaccines and hold promise for ensuring greater efficacy in preventing seasonal influenza outbreaks.
Do anti-takeover provisions restrain IPO underpricing? An analysis from the perspective of information asymmetry
Authors: Chen Kejing , Li Xiaolin , Wan Qingqing , Ye Jing , Yang Mo 
Published: January 2024

PurposeBased on the textual-analyzed data covering 2148 IPO firms in China’s stock market during the 2007–2018 period, the authors’ purpose is to examine the influence of anti-takeover provision (ATP) adoption on initial public offerings (IPO) underpricing and identify the reducing effect of the former.Design/methodology/approachThe authors examine the sample consisting of Chinese A-share listed IPO firms between 2007 and 2018 from China Stock Market Accounting Research and Chinese Research Data Services, with ATP data collected from the IPO firm chapters. Specifically, the authors use text analysis to identify whether there are ATPs in the IPO firm chapters, as well as the number of ATPs. H1: IPO underpricing is less severe for firms adopting ATPs. H2: The effect of ATP adoption on IPO underpricing is more salient for firms in worse information environments.FindingsThe authors examine the influence of ATP adoption on IPO underpricing and identify the reducing effect of the former. This effect can be explained by the fact that adopting ATPs in IPO firm chapters can reduce information asymmetry to a large extent by helping external investors obtain more private information, which alleviates IPO underpricing. The authors also find that the reducing effect is more significant in the worsened information environment. Furthermore, the authors explore the influence of adopting ATPs on other IPO characteristics and find positive effects on IPO over-subscription, funds raised and trading activity and negative effects on listing fees.Originality/valueThis study mainly contributes to the literature from the following two aspects. First, the study enriches the literature about the influencing factors of IPO underpricing. Second, the study also enriches the literature about the economic consequences of ATP adoption. This study also has important policy implications. With the coming of the era of decentralized ownership in China’s capital market, ATP adoption has become more important and attracted more attention. Also, investors focus more on pricing efficiency. The findings in this paper provide a more comprehensive understanding of the relationship between ATP adoption and IPO underpricing.
Feasibility in embedding charismatic leadership strategies into social work applications
Authors: Grinev Lana 
Published: December 2023

PurposeThe purpose of this paper is to determine whether charismatic leadership strategies can be successfully implemented within structures, systems and tasks for social workers to increase case management successes, particularly client well-being, given that the six key charismatic leadership traits align with presented professionally bound ethical expectations.Design/methodology/approachA short generic qualitative review was done over fifteen publications, emphasizing the effects of charismatic leadership in domestic and foreign occupational domains.FindingsMethodological, thematic and theoretical analyses show that charismatic leadership strategies are active in relevant social work domains with positive participant impacts.Practical implicationsThe paper is intended to primarily investigate whether charismatic leadership is present in social work domains, and does not consider other leadership modalities.Originality/valueHigh-quality reviews from the presented methodological investigations suggest that charismatic leadership is an effective leadership modality that should be considered into client-involved structures and systems.
Triadic multilevel psychic distance in firm internationalization
Authors: Safari Aswo 
Published: January 2024

PurposeThis study focuses on the triadic multilevel psychic distance (MPD) between the firm, target market and bridge-maker and its consequences for firm internationalization. Specifically, it spotlights the triadic psychic distance between firms, the levels of psychic distance in the target market (country and business) and the bridge-maker. Therefore, this study examines the triadic MPD among these three entities and its impact on firm internationalization.Design/methodology/approachThis study uses qualitative and case study research approaches. It is based on 8 case companies and 24 internationalization cases. Secondary data were collected, and interviews with bridge-makers and industry experts were conducted.FindingsThe study found that MPD appeared in the triad. The MPD between firms and markets is related to country-specific differences and business difficulties. The MPD between the firm and the bridge-maker is based on the latter’s lack of knowledge vis-à-vis bridging the firm’s MPD. Finally, the MPD between bridge-makers and the market is based on the former’s lack of knowledge of the home country’s business difficulties.Originality/valueThis is the first study to develop and adopt a triadic multilevel psychic distance conceptualization that provides evidence for and sheds light on the triadic MPD and its effect on firm internationalization. This study identifies the reasons behind triadic MPD in connection to firm internationalization. Notably, firm internationalization is interdependent on the triadic MPD setting between the firm, bridge-maker and target market. It has theoretical value and contributes to the recent advancement in the understanding of MPD in international marketing literature.
Food, nutrition and the dining experience in aged care settings: Findings of a nationwide survey
Authors: Mellow Maddison L. , Luscombe‐Marsh Natalie , Taylor Pennie J. , Kenny Peter , Lushington Kurt 
Published: December 2023

AbstractObjectivePrevious research on food, nutrition and dining practices in Australian residential aged care (RAC) homes has been based on a limited sample of single‐home or multiple‐home providers, but a nationwide study has not been conducted. The aim of this study was to provide a preliminary overview of current food, nutrition and dining practices across Australian RAC facilities using a nationwide survey.MethodsA survey was distributed to Australian RAC homes in August–September 2020, as part of the National Congress on Food, Nutrition and the Dining Experience in Aged Care (February 2021). The survey, administered via an online portal, consisted of 38 semistructured questions including yes/no or multiple‐choice responses, free text, frequency scales and number entry. Six key topics were explored, including ‘food service system and environment’, ‘catering style’, ‘menu planning and evaluation’, ‘nutrition planning and requirements’, ‘nutrition‐related screening and assessment’ and ‘training and additional information’, which were informed by the Australian Government Department of Health and reflected the interests of the Congress.ResultsThe final sample included 292 respondents (204 individual homes and 88 multiple‐home proprietors) representing 1152 homes and 125,393 residents, encompassing approximately 43% of RAC homes (of a possible 2671) and 57% of residents (of a possible 219,965) in Australia. Survey respondents representing RAC homes included service managers, catering managers, Chief Executive Officers, cooks, chefs, dietitians or staff from other roles within homes. A number of potential areas of need were identified, included increasing the autonomy of residents to select the foods they desire, increasing the variety and choice (including timing) of meals, enhancing the dining environments in homes to stimulate food intake and increasing staff training and the number of trained chefs in homes, so that meals are prepared which address diverse nutritional needs of residents.ConclusionsThis study provides insight into the food service and mealtime practices of over a third of Australian RAC homes. The findings of this survey may help to identify key targets for intervention to improve the food, nutrition and quality of life of aged care residents.
Integrated indoor positioning methods to optimize computations and prediction accuracy enhancement
Authors: Kim Yongho , Kim Jiha , You Cheolwoo , Park Hyunhee 
Published: January 2024

AbstractIndoor GPS location estimation encounters accuracy challenges from intricate building structures and diverse signal interferences. Trilateration methods utilising APs are typically employed to estimate indoor locations. Nevertheless, estimation errors from multipath effects and high power consumption of sensors employed in location estimation curtail battery life. To address this issue, research into location estimation methods utilising machine learning has been conducted. However, challenges involving the selection of the optimal access point locations and obtaining dense RSSI data have been noted. In this article presents a solution based on sparse radio maps for decreasing the expenses of collecting RSSI data while simultaneously enhancing indoor location accuracy through the integration of image data. The proposed approach integrates matrix‐based RSSI indoor positioning (M‐RIP) for initial location estimation and feature‐based image indoor positioning (F‐IIP) for position determination via image feature matching. Furthermore, extended area‐based post‐processing (EA‐PP) is employed to augment M‐RIP's precision and minimize image matching computation in F‐IIP, improving overall performance. This article utilizes actual building data to validate the precision of the position estimation and efficiency of computation reduction using the proposed method.
Passenger name record (PNR) data: How the EU is promoting (virtual) security by actually limiting Passengers' fundamental rights
Authors: De Capitani Emilio 
Published: January 2024

AbstractThe use for security purposes of airline passenger data (PNR) has gradually come to the fore especially in EU‐US relations because of the tension between those who considered the use of PNR an effective tool in the fight against terrorism and those who considered the interference in citizens' privacy disproportionate. The Court of Justice intervened decisively on the issue in June 2022 with the “Ligue des Droits Humains” Judgment C‐817/19. This ruling should have been followed by a review of the national legislations that transposed the Directive. On the contrary, the Member States are still going in the opposite direction to that indicated by the Court.
Pediculicide regulations and usage trends in Türkiye in 2015–2022
Authors: Sensoz Sabiha , Bilgener Emrah , Mumcuoglu Kosta Y. , Taylan‐Ozkan Aysegul 
Published: January 2024

AbstractBackgroundOver the years, the increasing prevalence of head lice infestation has led to an increase in treatment‐related costs and the development of resistance to pediculicides. This study aimed to evaluate pediculicide sales over an 8‐year period (2015–2022), including the COVID‐19 pandemic.MethodsData on products registered in the Turkish Pharmaceutical Index Dataview, Intercontinental Medical Statistics (IMS) database, sold on prescription and approved by the Ministry of Health in Türkiye were formally requested from the research organization IQVIA for pharmacologically active pediculicides (PAP) such as permethrin, pyrethrin, and sumithrin. Data for physically active products containing dimethicone (DMT) were obtained from the relevant pharmaceutical companies. Sale revenues were determined based on sale prices in the aforementioned year.ResultsTotal sales of pediculicides decreased from 2,452,846 units in 2015 to 2,028,840 units in 2022. While PAP consumption decreased over the years, from 1,832,006 to 518,460 units, DMT consumption increased from 620,840 to 1,510,380 units, from 2015 to 2022. The total price of pediculicides for the consumer increased more than threefold in Turkish currency. In terms of USD, an almost similar amount of money was spent over the years, with the exception of 2022 when the expenditure almost halved mainly due to the high inflation rate in the country.ConclusionThe decrease in PAP and the increase in DMT indicate that local lice have developed resistance to the former. Further studies are needed to determine the possible development of resistance in the country.
Lens power, cornea power and association with refractive error in children with moderate to high hyperopia
Authors: Wang Zhirong , Luo Ruiyu , Zhuo Yehong , Deng Daming 
Published: January 2024

AbstractObjectiveThis study aimed to profile ocular biometry parameters and predictors of spherical equivalent refraction (SER) among children with moderate to high hyperopia.MethodsIndividuals <18 years of age with moderate to high hyperopia were enrolled from November 2015 to November 2021. Participants underwent a series of comprehensive ocular examinations, and were classified as having low hyperopia, that is, SER +0.5 to < +2.0 D or moderate to high hyperopia, that is, SER ≥ +2.0 D.ResultsA total of 459 and 230 eyes with moderate to high hyperopia and low hyperopia, respectively, were included. Moderate to high hyperopic eyes had a shorter axial length, stronger lens power (24.78 ± 5.47 D vs. 18.74 ± 1.63 D, p < 0.001) and weaker corneal power (42.82 ± 1.75 D vs. 43.31 ± 1.55 D, p < 0.001) than low hyperopic eyes. When comparing values before and after 5 years of age, both lens power and axial length differed significantly in the moderate to high hyperopia group, whereas in the low hyperopia group, they only differed significantly after 9 years of age. Lens power was negatively associated with AL in eyes with axial lengths between 20 and 22 mm. A multiple linear regression model which included axial length (standardised β = −0.80, p < 0.001), corneal power (standardised β = −0.47, p < 0.001) and lens power (standardised β = 0.23, p < 0.001) explained 81.2% of the variance in SER.ConclusionsDifferences in lens power and axial length in moderate to high hyperopic eyes became significantly smaller after 5 years of age, at least 4 years earlier than for the low hyperopia. Lens power could offset the axial elongation in participants with axial lengths between 20 and 22 mm, suggesting that children with moderate to high hyperopia might have different ocular growth patterns. Axial length, corneal power and lens power were the main predictors of SER in moderate to high hyperopia.
A gentle introduction to principal component analysis using tea‐pots, dinosaurs, and pizza
Authors: Saccenti Edoardo 
Published: January 2024

AbstractPrincipal Component Analysis (PCA) is a powerful statistical technique for reducing the complexity of data and making patterns and relationships within the data more easily understandable. By using PCA, students can learn to identify the most important features of a data set, visualize relationships between variables, and make informed decisions based on the data. As such, PCA can be an effective tool to increase students data literacy by providing a visual and intuitive way to understand and work with data. This article outlines a teaching strategy to introduce and explain PCA using basic mathematics and statistics together with visual demonstrations.
Donor blood cultures and outcomes after lung transplantation: a single‐center report
Authors: Hashim Mahmoud , Saleh Rana Ahmed , Abdulqawi Rayid , Albachir Chams Alkhalaf , Aldakhil Haifa , AlKattan Khaled Manae , Almaghrabi Reem Saad , Hamad Alaa , Saleh Waleed , Al‐Mutairy Eid Abdullah 
Published: December 2023

AbstractBackgroundTransplanting lungs from donors with positive blood cultures has not been shown to adversely affect survival. There is limited evidence for potential effects on other outcomes, such as hospital course, graft function, and transmission of infection.MethodsThis retrospective cohort study included adult patients who underwent lung‐only transplantation for the first time between March 2010 and December 2022. Outcomes of patients whose donors had positive blood cultures within 72 h of transplant were compared to patients whose donors had negative blood cultures.ResultsTwenty‐five (10.8%) of 232 donors had positive blood cultures, including a single, unexpected case with candidemia. The most commonly isolated bacteria were Enterobacter cloacae (n = 5), Klebsiella pneumoniae (n = 5), Acinetobacter baumannii (n = 3), Pseudomonas aeruginosa (n = 3), and Staphylococcus aureus (n = 3). Eleven donors had identical bacteria in their respiratory cultures. All patients who were transplanted from donors with positive blood cultures survived beyond 90 days. Positive donor blood cultures were not associated with longer hospital stay, in‐hospital complications, acute cellular rejection, or the achievement of 80% predicted forced expiratory volume in the first second. Probable transmission of donor bacteremia occurred in only two cases (both with S. aureus). These two donors had positive respiratory cultures with the same organism.ConclusionThe study did not find an increased risk of adverse events when transplanting lungs from donors with positive blood cultures. Allograft cultures may be more predictive of the risk of transmitting infections.
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Health Risk Assessment of AIMS Employees: Basis towards the Development of an Enhanced Wellness Program
Authors: Garibay Marianne , Amonceda Angelina 
Published: January 2024

This study explored the relationship between medical and mental health status among Asian Institute of Maritime Studies (AIMS) employees, employing statistical analyses such as Pearson correlation coefficients and t-tests. The results indicated a lack of significant correlation between medical and mental health status, suggesting no strong evidence supporting a relationship. Gender differences in health concerns were evident, with female employees reporting significantly higher levels of mental health concerns compared to their male counterparts. However, no substantial gender-based disparity was found in medical health concerns. Civil status also emerged as a significant factor, with single employees exhibiting notably higher mental health concerns than their married counterparts. Medical history included high blood pressure, stomach pain/ulcer, and nose/throat issues, with some reporting alcohol and smoking history. A minority were currently on medications for blood pressure, cholesterol, and diabetes. The study highlights the need to address mental health, especially among female employees, and implement strategies to reduce stress and enhance well-being in the workplace at AIMS.
In light of these findings, the study recommended targeted programs addressing mental health concerns among AIMS employees, emphasizing accessibility to counseling services and collaborative efforts with the Human Resource Management Office (HRMO). Additionally, initiatives promoting digital literacy, fitness programs, and team-building activities were suggested. Recognizing the importance of early intervention, the study encouraged employees to consult with healthcare professionals for appropriate diagnosis and treatment measures for managing depression.