bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convergence of Dynamics on Inductive Systems of Banach Spaces
Authors: van Luijk Lauritz , Stottmeister Alexander , Werner Reinhard F. 
Published: February 2024

AbstractMany features of physical systems, both qualitative and quantitative, become sharply defined or tractable only in some limiting situation. Examples are phase transitions in the thermodynamic limit, the emergence of classical mechanics from quantum theory at large action, and continuum quantum field theory arising from renormalization group fixed points. It would seem that few methods can be useful in such diverse applications. However, we here present a flexible modeling tool for the limit of theories, soft inductive limits, constituting a generalization of inductive limits of Banach spaces. In this context, general criteria for the convergence of dynamics will be formulated, and these criteria will be shown to apply in the situations mentioned and more.
Nonlinear acoustic equations of fractional higher order at the singular limit
Authors: Nikolić Vanja 
Published: February 2024

AbstractWhen high-frequency sound waves travel through media with anomalous diffusion, such as biological tissues, their motion can be described by nonlinear acoustic equations of fractional higher order. In this work, we relate them to the classical second-order acoustic equations and, in this sense, justify them as their approximations for small relaxation times. To this end, we perform a singular limit analysis and determine their behavior as the relaxation time tends to zero. We show that, depending on the nonlinearities and assumptions on the data, these models can be seen as approximations of the Westervelt, Blackstock, or Kuznetsov wave equations in nonlinear acoustics. We furthermore establish the convergence rates and thus determine the error one makes when exchanging local and nonlocal models. The analysis rests upon the uniform bounds for the solutions of the acoustic equations with fractional higher-order derivatives, obtained through a testing procedure tailored to the coercivity property of the involved (weakly) singular memory kernel.
Life in a Central European warm-temperate to subtropical open forest: Paleoecology of the rhinocerotids from Ulm-Westtangente (Aquitanian, Early Miocene, Germany)
Authors: Hullot Manon , Martin Céline , Blondel Cécile , Rössner Gertrud E. 
Published: February 2024

AbstractThe Ulm-Westtangente locality has yielded the most abundant vertebrate fauna from the Aquitanian stage in Germany. Its dating to the Mammal Neogene Zone 2a, a turnover in Cenozoic climate, makes it a crucial source for the understanding of faunal, paleoecological and paleoenvironmental specifics of the European Aquitanian. However, while most taxa from Ulm-Westtangente have been studied, little to no research has been conducted on the large herbivores, particularly on the two rhinocerotids Mesaceratherium paulhiacense and Protaceratherium minutum. Here, we used a multi-proxy approach to investigate the paleoecology of these two species. The remains of the smaller species P. minutum (438 to 685 kg) are twice as abundant as those of the larger M. paulhiacense (1389 to 2327 kg), but both display a similar age structure (~ 10% of juveniles, 20% of subadults and 70% of adults), mortality curves, and mild prevalence of hypoplasia (~ 17%). Results from dental mesowear, microwear, and carbon isotopes indicate different feeding preferences: both were C3 feeders but M. paulhiacense had a more abrasive diet and was probably a mixed feeder. Our study on rhinocerotids also yielded new paleoenvironmental insights, such as the mean annual temperature (15.8 °C) and precipitation (317 mm/year) suggesting rather warm and dry conditions.
Biochemical Response of the Endogeic Earthworm (Balanteodrilus extremus) Exposed to Tropical Soils
Authors: Sánchez-del Cid E. Lucero , Osten Jaime Rendón-von , Dzul-Caamal Ricardo , González-Chávez Ma. del Carmen Ángeles , Torres-Dosal Arturo , Huerta-Lwanga Esperanza 
Published: February 2024

AbstractThis work evaluated the biochemical responses of the endogeic earthworm Balanteodrilus extremus exposed for 14 and 48 days (d) to soils collected from two tropical agricultural systems: maize-sorghum (MS) and soybean-sorghum (SS). A soil without agricultural management (WAM) and the use of pesticides was selected as a reference. The presence of organochlorine (OC) and organophosphate (OP) pesticide residues was quantified in MS and SS soils. Biomarkers of detoxification [glutathione S transferase (GST)], neurotoxicity [acetylcholinesterase (AChE)] and oxidative stress [superoxide dismutase (SOD), catalase (CAT) and lipoperoxidation (LPO)] were evaluated in B. extremus. The concentration of OP pesticide residues was higher in SS than in MS. Activity of AChE in B. extremus exposed to SS soil for 14 d was significantly more inhibited (78%) than in MS soil (68%). B. extremus has been shown to be a good bioindicator of contaminated soils in tropical regions.
Surface topology modification using 3D printing techniques to enhance the interfacial bonding strength between polymer substrates and prepreg carbon fibre-reinforced polymers
Authors: Abdoli Hamed , Diegel Olaf , Bickerton Simon 
Published: February 2024

AbstractCarbon fibre-reinforced polymers (CFRPs) are increasingly utilised in combination with plastics and metals to manufacture hybrid components. Although hybrid components provide a combination of the advantages of the constituent materials, there are some challenges for the manufacture of high-quality hybrid components, including potentially weak interfacial bonding between the constituent materials. This paper presents a study focused on enhancing the interfacial strength of hybrid components by using additive manufacturing (AM) to manipulate the surface topology of a substrate component. Specifically, the study involved conducting experiments on a polyamide/CFRP hybrid component in which the PA12 substrates were manufactured with a controlled surface topology using polymer powder bed fusion. The mechanical testing study revealed several key findings, including an increase in bonding strength by modifying the substrate surface features, and significant improvements in out-of-plane interlaminar bonding strength by adding substrate surface features such as pins or fluorite lattices. It is shown that normal strength was enhanced by up to 53% between the substrate and pure epoxy, and by 126% between the substrate and a CFRP laminate. These results highlight the potential benefits of using AM technologies to enhance the interfacial strength of hybrid components and suggest directions for future research in this area.
A short guide on blue fluorescent proteins: limits and perspectives
Authors: Seo Pil-Won , Kim Geun-Joong , Kim Jeong-Sun 
Published: February 2024

Abstract
The advent of the so-called colorful biology era is in line with the discovery of fluorescent proteins (FPs), which can be widely used to detect the intracellular locations of macromolecules or to determine the abundance of metabolites in organelles. The application of multiple FPs that emit different spectra and colors could be implemented to precisely evaluate cellular events. FPs were initially established with the emergence of the green fluorescent protein (GFP) from jellyfish. Red fluorescent proteins (RFPs) from marine anemones and several corals adopt fluorescent chromophores that are similar to GFP. Chromophores of GFP and GFP-like FPs are formed through the oxidative rearrangement of three chromophore-forming residues, thereby limiting their application to only oxidative environments. Alternatively, some proteins can be fluorescent upon their interaction with cellular prosthetic cofactors and, thus, work in aerobic and anaerobic conditions. The modification of an NADPH-dependent blue fluorescent protein (BFP) also expanded its application to the quantization of NADPH in the cellular environment. However, cofactor-dependent BFPs have an intrinsic weakness of poor photostability with a high fluorescent background. This review explores GFP-derived and NADPH-dependent BFPs with a focus on NADPH-dependent BFPs, which might be technically feasible in the near future upon coupling with two-photon fluorescence microscopy or nucleic acid-mimickers.

Key points
• Oxidation-dependent GFP-like BFPs and redox-free NADPH-dependent BFPs
• GFPs of weak photostability and intensity with a high fluorescent background
• Real-time imaging using mBFP under two-photon fluorescence microscopy
Enzymatic upcycling of wild-simulated ginseng leaves for enhancing biological activities and compound K
Authors: Lim Juho , Kim Hayeong , Kim Gha-hyun J. , Kim Taeyoon , Kang Choon Gil , Kim Seung Wook , Kim Doman 
Published: February 2024

AbstractCompound K (CK), a ginsenoside with high bioavailability, is present at low levels in wild-simulated ginseng leaves (WSGL). WSGL contains the CK precursors, Rd and F2, in amounts up to 26.4 ± 0.4 and 24.1 ± 1.9 mg/g extract, respectively. In this study, CK production in WGSL reached 25.9 ± 1.0 mg/g extract following treatment with Viscozyme, Celluclast 1.5 L, Pectinex Ultra SP-L, and their combination. The antioxidant activities indicated by oxygen radical absorbance capacity, ferric reducing antioxidant power, and ABTS- and DPPH radical scavenging activity of enzyme-treated WSGL were enhanced 1.69-, 2.51-, 2.88-, and 1.80-fold, respectively, compared to non-treated WSGL. Furthermore, the CK-enriched WSGL demonstrated a 1.94-fold decrease in SA-β-galactosidase expression in human dermal fibroblasts and a 3.8-fold enhancement of inhibition of nitric oxide release in lipopolysaccharide-induced RAW 264.7 cells relative to non-treated WSGL. Consequently, WSGL subjected to enzymatic upcycling has potential as a functional material in the food and pharmaceutical industries.
High-yield BMP2 expression in rice cells via CRISPR and endogenous αAmy3 promoter
Authors: Nguyen Thi Mai , Wu Pei-Yi , Chang Chih-Hung , Huang Li-Fen 
Published: February 2024

Abstract
Plant cells serve as versatile platforms for the production of high-value recombinant proteins. This study explored the efficacy of utilizing an endogenous αAmy3 promoter for the expression of a bioactive pharmaceutical protein, specifically the mature region of human bone morphogenetic protein 2 (hBMP2m). Utilizing a refined CRISPR/Cas9-mediated intron-targeting insertion technique, which incorporates an artificial 3’ splicing site upstream of the target gene, we achieved a transformation efficiency of 13.5% in rice calli that carried the rice-codon optimized mature region of hBMP2 cDNA (rhBMP2m) in the αAmy3 intron 1. Both homozygous and heterozygous rhBMP2m knock-in rice suspension cell lines were generated. These lines demonstrated the endogenous αAmy3 promoter regulated rhBMP2m mRNA and rhBMP2m recombinant protein expression, with strongly upregulation in respond to sugar depletion. The homozygous rhBMP2m knock-in cell line yielded an impressive 21.5 μg/mL of rhBMP2m recombinant protein, accounting for 1.03% of the total soluble protein. The high-yield expression was stably maintained across two generations, indicating the genetic stability of rhBMP2m gene knock-in at the αAmy3 intron 1 locus. Additionally, the rice cell-derived rhBMP2m proteins were found to be glycosylated, capable of dimer formation, and bioactive. Our results indicate that the endogenous rice αAmy3 promoter–signal peptide-based expression system is an effective strategy for producing bioactive pharmaceutical proteins.

Key points
• The endogenous αAmy3 promoter-based expression system enhanced the yield of BMP2
• The increased yield of BMP2 accounted for 1.03% of the total rice-soluble proteins
• The rice-produced BMP2 showed glycosylation modifications, dimer formation, and bioactivity
Thermodynamic characteristics of extreme heat waves over the middle and lower reaches of the Yangtze River Basin
Authors: Liu Wencai , Shi Ning , Wang Huijun , Huang Qilei 
Published: February 2024

AbstractIn August 2022, an exceptionally long-lasting heat wave (HW) affected the middle and lower reaches of the Yangtze River basin. This study uses the JRA55 daily reanalysis datasets to elucidate the thermodynamic characteristics of the daily evolution of historical extreme HWs in this region via the heat budget equation. HWs are generally characterized by the occurrence of anticyclonic circulation anomaly throughout the troposphere and positive air temperature anomaly with the maximum amplitude in the boundary layer. The anticyclonic anomaly can induce compression heating in the entire troposphere and warm zonal advection in the boundary layer. Meanwhile, due to the reduced cloud cover, more shortwave radiation reaches the ground surface, and the sensible heat flux becomes an important source of diabatic heating before the onset of HWs. The accumulated excessive heat in the HWs is primarily damped through the emission of longwave radiation and meridional thermal advection. For the HW in August 2022, its extreme persistence is mainly caused by prolonged adiabatic heating, enhanced diabatic heating during the developing stage and weakened diabatic cooling during the decay stage. The upper-level portion of the anticyclonic circulation anomalies is linked to the strengthened South Asia High. After applying the state-of-the-art dynamic metric, i.e., local finite wave activity, we reveal that the formation of the anomalous South Asia High in August 2022 is associated with the Stokes drift flux rather than the dispersion of Rossby wave energy. This characteristic sets it apart from other extreme HWs.
Valve unit instead of intensive or intermediate care unit admission following transcatheter edge-to-edge mitral valve repair is safe and reduces postprocedural complications
Authors: Gröger Matthias , Felbel Dominik , Paukovitsch Michael , Schneider Leonhard Moritz , Markovic Sinisa , Rottbauer Wolfgang , Keßler Mirjam 
Published: February 2024

Abstract
Background
Transcatheter edge-to-edge mitral valve repair (M-TEER) is often performed in general anesthesia, and postprocedural monitoring is usually warranted on an intensive or intermediate care unit (ICU/IMC). We evaluated the implications of a dedicated valve unit (VU) instead of an ICU/IMC for monitoring after M-TEER.

Methods and results
In total, 624 patients were retrospectively analyzed. A total of 312 patients were primarily transferred to either ICU or IMC following M-TEER, and 312 patients were scheduled for the VU in the absence of indications for ICU/IMC treatment. Hospital stay was significantly shorter in VU patients (median 6.0 days (interquartile range (IQR) 5.0 – 8.0) vs. 7.0 days (IQR 6.0 – 10.0), p < 0.001) and their risk for infections (2.9 vs. 7.7%, p = 0.008) and delirium (0.6 vs. 2.6%, p = 0.056) was substantially lower compared to ICU/IMC patients. In-hospital mortality was similar in both groups (0.6% vs. 1.3%, p = 0.41).
Fifty patients (16.0%) in the VU group had to cross over to unplanned ICU/IMC admission. The most frequent indication was prolonged need for catecholamines (52.0%). Patients with ICU/IMC crossover had more advanced stages of heart failure (LV-EF < 30% in 36.0 vs. 16.0%, p = 0.001; severe concomitant tricuspid regurgitation in 48.0 vs. 27.8%, p = 0.005) and an LV-EF < 30% was independently associated with unplanned ICU/IMC admission.

Conclusions
Following M-TEER postprocedural monitoring on a VU instead of an ICU/IMC is safe, reduces complications, and spares ICU capacities. Patients with advanced heart failure have a higher risk for unplanned ICU/IMC treatment after M-TEER.

Graphical abstract
Valve unit instead of intensive or intermediate care unit admission following transcatheter edge-to-edge mitral valve repair is safe and reduces postprocedural complications.
Sex-related differences in patients presenting with heart failure–related cardiogenic shock
Authors: Sundermeyer Jonas , Kellner Caroline , Beer Benedikt N. , Besch Lisa , Dettling Angela , Bertoldi Letizia Fausta , Blankenberg Stefan , Dauw Jeroen , Dindane Zouhir , Eckner Dennis , Eitel Ingo , Graf Tobias , Horn Patrick , Jozwiak-Nozdrzykowska Joanna , Kirchhof Paulus , Kluge Stefan , Linke Axel , Landmesser Ulf , Luedike Peter , Lüsebrink Enzo , Majunke Nicolas , Mangner Norman , Maniuc Octavian , Möbius-Winkler Sven , Nordbeck Peter , Orban Martin , Pappalardo Federico , Pauschinger Matthias , Pazdernik Michal , Proudfoot Alastair , Kelham Matthew , Rassaf Tienush , Scherer Clemens , Schulze Paul Christian , Schwinger Robert H. G. , Skurk Carsten , Sramko Marek , Tavazzi Guido , Thiele Holger , Villanova Luca , Morici Nuccia , Winzer Ephraim B. , Westermann Dirk , Schrage Benedikt 
Published: February 2024

Abstract
Background
Heart failure–related cardiogenic shock (HF-CS) accounts for a significant proportion of all CS cases. Nevertheless, there is a lack of evidence on sex-related differences in HF-CS, especially regarding use of treatment and mortality risk in women vs. men. This study aimed to investigate potential differences in clinical presentation, use of treatments, and mortality between women and men with HF-CS.

Methods
In this international observational study, patients with HF-CS (without acute myocardial infarction) from 16 tertiary-care centers in five countries were enrolled between 2010 and 2021. Logistic and Cox regression models were used to assess differences in clinical presentation, use of treatments, and 30-day mortality in women vs. men with HF-CS.

Results
N = 1030 patients with HF-CS were analyzed, of whom 290 (28.2%) were women. Compared to men, women were more likely to be older, less likely to have a known history of heart failure or cardiovascular risk factors, and lower rates of highly depressed left ventricular ejection fraction and renal dysfunction. Nevertheless, CS severity as well as use of treatments were comparable, and female sex was not independently associated with 30-day mortality (53.0% vs. 50.8%; adjusted HR 0.94, 95% CI 0.75–1.19).

Conclusions
In this large HF-CS registry, sex disparities in risk factors and clinical presentation were observed. Despite these differences, the use of treatments was comparable, and both sexes exhibited similarly high mortality rates. Further research is necessary to evaluate if sex-tailored treatment, accounting for the differences in cardiovascular risk factors and clinical presentation, might improve outcomes in HF-CS.

Graphical abstract
Sex-related differences in clinical characteristics, shock severity, and mortality in patients with heart failure–related cardiogenic shock. Summary for the main study findings. AMI, acute myocardial infarction; CI, confidence interval; HF-CS, heart failure–related cardiogenic shock; LVEF, left ventricular ejection fraction; MCS, mechanical circulatory support; SCAI, Society for Cardiovascular Angiography & Interventions.
Cochlear implant therapy improves the quality of life and social participation in the elderly: a prospective long-term evaluation
Authors: Issing Christian , Loth Andreas G. , Sakmen Kenan D. , Guchlerner Leon , Helbig Silke , Baumann Uwe , Pantel Johannes , Stöver Timo 
Published: February 2024

Abstract
Purpose
In recent years, the number of elderly cochlear implant (CI) candidates is continuously rising. In addition to the audiological improvement, other positive effects of CI treatment can also be observed in clinical routine. The “quality of life” as a parameter of success directly experienced by the patient is increasingly becoming the focus of clinical research. Although there are already clear indications of a rapid and significant improvement in quality of life, there is still a lack of systematic, prospectively collected longitudinal long-term data in patients over the age of 65.

Methods
This prospective longitudinal observational study included 31 patients between the age of 71 and 92 years who had first been treated unilaterally with a CI 6 years ago. In addition to free-field monosyllable recognition, quality of life was assessed using the World Health Organization Quality-of-Life Scale-old (WHOQL-OLD). The results were compared with the data from our previous study, in which we focused on the short- and medium-term effects on quality of life. In both studies, the same patient population was examined. In addition, these study data were compared with an age-matched average population.

Results
In speech recognition, there was no significant change from the control 6 months postoperatively compared with the results 6 years postoperatively. No significant changes occurred in the total quality of life score or any of the other six facets of quality of life when comparing the results 6 months postoperatively with the results 6 years postoperatively. In “Social participation”, the CI patients even exceed the values of the age-matched average population 6 years after treatment.

Conclusion
Improvement in the quality of life and especially in social participation appears stable over many years in elderly patients after hearing rehabilitation with a CI.
Posterior fixation of gastric tube with fibrin sealant in laparoscopic sleeve gastrectomy: a promising method to prevent revision surgeries
Authors: Kizilkaya Mehmet Celal , Gokay Ridvan , Mutlu Arda Ulaş , Sonmez Suleyman , Yilmaz Serhan , Kocatas Ali , Saracoglu Can , Aytac Erman 
Published: February 2024

Abstract
Background
We aim to assess the effects of gastric posterior fixation with fibrin sealant in laparoscopic sleeve gastrectomy in aspects of 12th-month body mass index and gastric volume.

Methods
The patients who underwent laparoscopic sleeve gastrectomy between January 2019 and February 2021 were divided into two groups preoperatively. The first 75 patients were appointed to the posterior fixation group, and the second 75 were to the control group. Changes in gastric volume and body mass index were assessed in the postoperative 12th month.

Results
There were 110 patients in the final analysis. Fifty-four patients had posterior fixation, and 56 had only laparoscopic sleeve gastrectomy. The posterior fixation group was superior in terms of total weight loss rate (39.1% vs. 34.5%, p<0.001) and less gastric volume increase rate (39.8% vs. 164.7%, p<0.001) in the postoperative 12th month.

Conclusion
Our study suggests that posterior fixation with fibrin sealant in laparoscopic sleeve gastrectomy is a promising method for preventing weight regain and creating a need for revision surgery.