bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrophilic coating aids radial sheath withdrawal and reduces patient discomfort following transradial coronary intervention: A randomized double‐blind comparison of coated and uncoated sheaths
Authors: Kiemeneij Ferdinand , Fraser Douglas , Slagboom Ton , Laarman GertJan , van der Wieken Ron 
Published: May 2003

AbstractRadial artery spasm may cause severe discomfort during radial artery sheath removal. A hydrophilic‐coated sheath may reduce the force required to remove a radial sheath. This force may be quantified using an automatic pullback device (APD). The objective of this study was to assess if a hydrophilic coating reduces the required force and discomfort associated with removal of a radial sheath following transradial coronary intervention. Ninety patients undergoing percutaneous coronary intervention via the radial artery were randomly assigned to two groups receiving either coated or uncoated introducer sheaths. Radifocus Introducer II (Terumo) 25 cm, 6 Fr radial sheaths and sheaths that were identical apart from the presence of the coating were used in all patients. The APD was used for sheath removal at the end of the procedure. Three patients (7%) in the coated group experienced discomfort during automatic sheath removal, compared to 12 patients (27%) in the uncoated group (P = 0.02). The maximum pullback force (MPF) was significantly lower in the coated compared to the uncoated group (0.24 ± 0.31 vs. 0.44 ± 0.33 kg; P = 0.003). Similarly, the mean pullback force was significantly lower in the coated group (0.14 ± 0.23 vs. 0.32 ± 0.24 kg; P < 0.001). Only one patient (2%) in each group had an MPF greater than 1.0 kg together with clinical evidence of radial artery spasm. Removal of the coated Terumo Radifocus sheath requires less force than an identical uncoated sheath. The coated sheath was also associated with less discomfort for the patient. Cathet Cardiovasc Intervent 2003;59:161–164. © 2003 Wiley‐Liss, Inc.
Rapid thrombectomy for treatment of macroembolization during percutaneous coronary intervention in the setting of acute myocardial infarction
Authors: Lorin Jeffrey D. , Liou Michael C. , Sedlis Steven P. 
Published: May 2003

AbstractWe report the use of the Export catheter as an urgent modality to aspirate thrombus that embolized down the left anterior descending artery during acute myocardial infarction. Cathet Cardiovasc Intervent 2003;59:219–222. Published 2003 Wiley‐Liss, Inc.
Catheter‐induced left main dissection: A treatment dilemma
Authors: Mulvihill Niall T. , Boccalatte Marco , Fajadet Jean , Marco Jean 
Published: May 2003

AbstractDiagnostic angiography is a routine diagnostic procedure in modern day cardiological practice. However, there are potential life threatening complications which can occasionally occur. We describe one such complication and detail the management and clinical outcome. Cathet Cardiovasc Intervent 2003;59:214–216. © 2003 Wiley‐Liss, Inc.
Trained and supervised physician assistants can safely perform diagnostic cardiac catheterization with coronary angiography
Authors: Krasuski Richard A. , Wang Andrew , Ross Carole , Bolles John F. , Moloney Erica L. , Kelly Larry P. , Harrison J. Kevin , Bashore Thomas M. , Sketch Michael H. 
Published: May 2003

AbstractUsing a prospectively collected database of patients undergoing cardiac catheterization, we sought to compare the outcomes of procedures performed by supervised physician assistants (PAs) with those performed by supervised cardiology fellows‐in‐training. Outcome measures included procedural length, fluoroscopy use, volume of contrast media, and complications including myocardial infarction, stroke, arrhythmia requiring defibrillation or pacemaker placement, pulmonary edema requiring intubation, and vascular complications. Class 3 and 4 congestive heart failure was more common in patients who underwent procedures by fellows compared with those undergoing procedures by PAs (P = 0.001). PA cases tended to be slightly faster (P = 0.05) with less fluoroscopic time (P < 0.001). The incidence of major complications within 24 hr of the procedure was similar between the two groups (0.54% in PA cases and 0.58% in fellow cases). Under the supervision of experienced attending cardiologists, trained PAs can perform diagnostic cardiac catheterization, including coronary angiography, with complication rates similar to those of cardiology fellows‐in‐training. Cathet Cardiovasc Intervent 2003;59:157–160. © 2003 Wiley‐Liss, Inc.
Primary angioplasty in CADASIL
Authors: Raghu Cherukupalli , Loubeyre Christophe , Obadia Edouard , Morice Marie Claude 
Published: May 2003

AbstractWe report an acute coronary event in a young patient suffering from cerebral autosomal dominant arteriopathy with sub‐cortical infarcts and leucoencephalopathy (CADASIL) successfully treated by primary angioplasty and direct stenting. Coronary involvement and pathophysiology of this genetic disorder is discussed. Cathet Cardiovasc Intervent 2003;59:235–237. © 2003 Wiley‐Liss, Inc.
Transjugular percutaneous Inoue balloon mitral commissurotomy in a patient with inferior vena cava obstruction after liver transplantation
Authors: Sullebarger J. Thompson , Coto Humberto , Lopez Enrique , Sayad Dany , Fontanet Hector L. 
Published: May 2003

AbstractPercutaneous transvenous mitral commissurotomy was performed successfully via the transjugular approach in a patient with severe rheumatic mitral stenosis and obstruction of the inferior vena cava due to prior liver transplantation. This case demonstrates the advantage of the jugular approach in patients with difficult anatomy. Cathet Cardiovasc Intervent 2003;59:261–265. © 2003 Wiley‐Liss, Inc.
Recanalization of chronic and long occlusive in‐stent restenosis using optical coherence reflectometry‐guided radiofrequency ablation guidewire
Authors: Chen Wai‐Hong , Ng William , Lee Pui‐Yin , Lau Chu‐Pak 
Published: May 2003

AbstractChronic total occlusions remain a challenge to interventionalists due to failure of crossing or perforation by strong wires. We describe the use of a system using optical coherence reflectometry for navigation and radiofrequency ablation to enable wire passage through occlusions that could not be crossed by conventional guidewires. Cathet Cardiovasc Intervent 2003;59:223–229. © 2003 Wiley‐Liss, Inc.
A Non‐Radical Mechanism for Methane Hydroxylation at the Diiron Active Site of Soluble Methane Monooxygenase
Authors: Yoshizawa Kazunari , Yumura Takashi 
Published: May 2003

AbstractWe propose a non‐radical mechanism for the conversion of methane into methanol by soluble methane monooxygenase (sMMO), the active site of which involves a diiron active center. We assume the active site of the MMOHQ intermediate, exhibiting direct reactivity with the methane substrate, to be a bis(μ‐oxo)diiron(IV) complex in which one of the iron atoms is coordinatively unsaturated (five‐coordinate). Is it reasonable for such a diiron complex to be formed in the catalytic reaction of sMMO? The answer to this important question is positive from the viewpoint of energetics in density functional theory (DFT) calculations. Our model thus has a vacant coordination site for substrate methane. If MMOHQ involves a coordinatively unsaturated iron atom at the active center, methane is effectively converted into methanol in the broken‐symmetry singlet state by a non‐radical mechanism; in the first step a methane CH bond is dissociated via a four‐centered transition state (TS1) resulting in an important intermediate involving a hydroxo ligand and a methyl ligand, and in the second step the binding of the methyl ligand and the hydroxo ligand through a three‐centered transition state (TS2) results in the formation of a methanol complex. This mechanism is essentially identical to that of the methane–methanol conversion by the bare FeO+ complex and relevant transition metal–oxo complexes in the gas phase. Neither radical species nor ionic species are involved in this mechanism. We look in detail at kinetic isotope effects (KIEs) for H atom abstraction from methane on the basis of transition state theory with Wigner tunneling corrections.
Identity Double‐Proton Transfer in (3Z)‐3‐Hydroxy‐1,4‐di(quinolin‐2‐yl)but‐3‐en‐2‐one
Authors: Ośmiałowski Borys , Kolehmainen Erkki , Gawinecki Ryszard 
Published: May 2003

AbstractAlthough there is a very fast (on the NMR timescale) double‐proton transfer in (1Z,3Z)‐3‐hydroxy‐4‐quinolin‐2‐yl‐1‐quinolin‐2(1H)‐ylidenbut‐3‐en‐2‐one (the product of the condensation of ethyl oxalate with 2lithiomethylquinoline), it is the only species present in chloroform solution. Comparison of the product of condensation of ethyl oxalate with 2lithiomethyl derivatives of pyridine (recent studies) and quinoline (present studies) shows that benzoannulation considerably affects the tautomeric equilibrium. The observed changes are not only quantitative but also qualitative. Moreover, contrary to the proton transfer in the pyridine tautomers, this process is fast in the quinoline tautomers. Comparison of the experimental and ab initio/DFT GIAO‐calculated 13C and 15N chemical shifts for the transition states in the proton‐transfer reactions between (1Z,3Z)‐ 3‐hydroxy‐4‐quinolin‐2‐yl‐1‐quinolin‐2(1H)‐ylidenbut‐3‐en‐2‐one and its tautomers support the theory that a concerted identity reaction takes place between the enolimine‐enaminone and enaminone‐enolimine tautomeric forms. As a consequence, the most stable tautomeric form, (1Z,3Z)‐1,4‐di(quinolin‐2‐yl)buta‐1,3‐diene‐2,3‐diol, is not present in the tautomeric mixture.
Preparation and Characterization of Organotin–Oxomolybdate Coordination Polymers and Their Use in Sulfoxidation Catalysis
Authors: Abrantes Marta , Valente Anabela A. , Pillinger Martyn , Gonçalves Isabel S. , Rocha João , Romão Carlos C. 
Published: May 2003

AbstractThe organotin–oxomolybdates [(R3Sn)2MoO4]⋅n H2O (R=methyl, n‐butyl, cyclohexyl, phenyl, benzyl) have been prepared and tested as catalysts for the oxidation of benzothiophene with aqueous hydrogen peroxide, at 35 °C and atmospheric pressure. In all cases, the 1,1‐dioxide was the only observed product. The kinetic profiles depend on the nature of the tin‐bound R group and also on the addition of a co‐solvent. For the tribenzyltin derivative, the apparent activation energies for sulfoxidation as a function of the co‐solvent are in the order 1,2‐dichloroethane (5 kcal mol−1)<ethanol<acetonitrile<water (27 kcal mol−1). The solid could be recovered by centrifugation from the three‐phase (solid–liquid–liquid) system containing 1,2‐dichloroethane. The catalyst was reused in a second reaction cycle with no significant loss of activity. Increasing the oxidant/substrate ratio from 2:1 to 6:1 allows the corresponding sulfone to be obtained in quantitative yield within 24 h. Changing the nature of the tin‐bound R group in the catalyst precursors modifies their physical properties and hence their catalytic performance. The variation in hydrophobic/hydrophilic character is important, since the Me, nBu and Cy derivatives crystallize as anhydrous compounds, whereas the other two derivatives are hydrates. The polymers also have different structures, as evidenced by Xray powder diffraction. Mo K‐edge and Sn K‐edge EXAFS spectroscopy confirmed that the structures arise from the self‐assembly of tetrahedral [MoO4]2− subunits and [R3Sn]+ spacers. The Mo⋅⋅⋅Sn separation in the trimethyltin derivative is a uniform 3.84 Å. By contrast, the EXAFS results revealed the coexistence of short (3.67–3.79 Å) and long (3.93–4.07 Å) Mo⋅⋅⋅Sn separations in the other coordination polymers. The catalyst precursors were also characterized in the solid state by thermogravimetric analysis, FTIR, and Raman spectroscopy, and MAS NMR (13C, 119Sn) spectroscopy.
Low‐Temperature IR and NMR Studies of the Interaction of Group 8 Metal Dihydrides with Alcohols
Authors: Gutsul Evgenii I. , Belkova Natalia V. , Sverdlov Maria S. , Epstein Lina M. , Shubina Elena S. , Bakhmutov Vladimir I. , Gribanova Tatiana N. , Minyaev Ruslan M. , Bianchini Claudio , Peruzzini Maurizio , Zanobini Fabrizio 
Published: May 2003

AbstractThe reactions of the octahedral dihydrido complexes [MH2(PP3)] [M=Fe, Ru, Os; PP3P(CH2CH2PPh2)3] with a variety of weak ROH acids have been studied by IR and NMR methods in either CH2Cl2or THF in the temperature range from 190 to 290 K. This study has allowed the determination of the spectral and thermodynamic properties associated with the formation of dihydrogen bonds (DHB) between the terminal hydrides and the OH group. Both the DHB enthalpy values and the hydride basicity factors (Ej) have been found to increase in the order Fe < Ru < Os. The proton transfer process, leading to the DHB complexes, and eventually toη2‐H2products, has been found to depend on the acidic strength of the alcohol as well as the nature of the solvent. Low temperature IR and NMR techniques have been used to trace the complete energy profile of the proton transfer process involving the osmium complex [OsH2(PP3)] with trifluoroethanol.
Supercritical Fluid Synthesis of Metal and Semiconductor Nanomaterials
Authors: Holmes Justin D. , Lyons Daniel M. , Ziegler Kirk J. 
Published: May 2003

AbstractIn the near future physical and economic constraints are expected to limit the continued miniaturisation of electronic and optical devices using current “top‐down” lithography‐based methods. Consequently, nonlithographic methods for synthesising and organising materials on the nanometre scale are required. In response to these technological needs a number of research groups are developing new supercritical fluids methodologies to synthesise and self‐assemble “building blocks” of nanomaterials, from the “bottom‐up”, into structurally complex device architectures. This concept paper highlights some of the recent advances in the synthesis of metal and semiconductor nanoparticles and nanowires by using supercritical fluids. In addition, we describe an efficient supercritical fluid approach for constructing ordered arrays of metal and semiconductor nanowires within mesoporous silica templates.
Organized Nanostructured Complexes of Inorganic Clusters and Surfactants That Exhibit Thermal Solid‐State Transformations
Authors: Camerel Franck , Antonietti Markus , Faul Charl F. J. 
Published: May 2003

AbstractFacile organization of the inorganic crown‐shaped [Ni3P3S12]3− ion (1) into room‐temperature liquid‐crystalline materials by complexation with double‐tail ammonium surfactants is achieved by the ionic self‐assembly (ISA) route. Small‐angle Xray diffraction, UV/Vis spectroscopy, and 31P NMR analyses reveal that these complexes show an interesting solid‐state structure transition. Upon heating, the inorganic crown species polymerizes to the inorganic polyelectrolyte $\rm{^{1}_{\infty }}$[NiPS4]−. This structural transition is reversible, and involves a solvent/dissolution cycle. The facile preparation and facile optional induction of phase and structural changes make these complexes candidates for a number of applications in which cooperative, metastable switching with sufficient contrast of optical and solid‐state properties is required.
The First Linear Multiphosphazene Having Five Different Types of Side Groups and Its Use as the Core of a Dendrimeric Species
Authors: Magro Germinal , Donnadieu Bruno , Caminade Anne‐Marie , Majoral Jean‐Pierre 
Published: May 2003

AbstractThe step‐by‐step synthesis of the first oligophosphazenes having more than two types of side functions is described. These multifunctionalized oligophosphazenes possess up to four phosphazene linkages and up to four types of functional side groups. These compounds may serve as models for a better understanding of electronic delocalization phenomena in linear inorganic chains, and constitute novel cores for the synthesis of new dendrimeric species possessing several types of functions as end groups, at the level of the core, and within the branches.
The Structure of the Sugar Residue in Glycated Human Serum Albumin and Its Molecular Recognition by Phenylboronate
Authors: Rohovec Jan , Maschmeyer Thomas , Aime Silvio , Peters Joop A. 
Published: May 2003

AbstractQuantification of the extent of glycation of human serum albumin (HSA) and of haemoglobin provides a record of average mid‐ and long‐term blood‐sugar concentrations, respectively; this is very useful for the management of diabetes. The reaction of D‐glucose with propylamine affords the corresponding Schiff base, N‐propylamino‐D‐glucoside, in the cyclic form. This compound is not stable: upon standing or treatment with acid it is converted, by an Amadori rearrangement, into N‐propylfructosamine. Both amino sugars occur predominantly in the β‐pyranose form. Phenylboronate forms highly stable boronate esters through binding of the cis 1,2‐diol moiety in the furanose form of N‐propylfructosamine. Between pH 5 and 10, an electrostatic interaction between the protonated amino group and the negatively charged boronate moiety affords an additional stabilisation of the ester. The Schiff base, however, has no observable interaction with phenylboronate. In aqueous solution the Schiff base is in equilibrium with propylamine and glucose. Upon addition of phenylboronate, this equilibrium shifts to the side of glucose due to the formation of highly stable phenylboronate esters of the β‐furanose form of this compound. After Amadori rearrangement, the sugar moieties in glycated human serum albumin have a similar structure, they occur as an equilibrium of the β‐pyranose (59 %), α‐furanose (19 %) and β‐furanose (24 %) anomers. The open form was not observed. The β‐furanose anomer is selectively recognised by phenylboronate.
1,3‐Dithiolanes from Cycloadditions of Alicyclic and Aliphatic Thiocarbonyl Ylides with Thiones: Regioselectivity
Authors: Huisgen Rolf , Mloston Grzegorz , Polborn Kurt , Sustmann Reiner 
Published: May 2003

AbstractThe regiochemistry of 1,3‐dithiolanes obtained from thiocarbonyl ylides 9 and thiones 10 shows a striking dependence on substituents. Previously and newly performed experiments indicate that sterically hindered cycloalkanethione S‐methylides and dialkylthioketone S‐methylides react with alicyclic and aliphatic thiones to give the 2,2,4,4‐tetrasubstituted 1,3‐dithiolanes 11 exclusively. Aryl groups in one or both reactants lead to a preference for, or even complete formation of, 4,4,5,5‐tetrasubstituted 1,3‐dithiolanes 12. Several mechanisms appear to be involved, but the paucity of experimental criteria is troubling. Quantum‐chemical calculations (see preceding paper) on the cycloaddition between thioacetone S‐methylide and thioacetone furnish lower activation energies for the concerted process than for the two‐step pathways via C,S‐ or C,C‐biradicals; the favoring of the 2,4‐substituted 1,3‐dithiolanes over the 4,5‐substituted type would be expected to increase with growing bulk of substituents. Aryl groups stabilize intermediate biradicals. Experimental criteria for the differentiation of regioisomeric dithiolanes are discussed. Thiocarbonyl ylides 9 are prepared by 1,3‐cycloadditions between diazomethane and thioketones and subsequent N2 elimination from the usually isolable 2,5‐dihydro‐1,3,4‐thiadiazoles 17; different ratios of the two rate constants lead to divergent product formation scenarios.
Cover Picture: Structure–Nucleophilicity Relationships for Enamines (Chem. Eur. J. 10/2003)
Authors: Kempf Bernhard , Hampel Nathalie , Ofial Armin R. , Mayr Herbert 
Published: May 2003

AbstractThe cover picture shows the exponential decay of the UV/Vis absorption of a diarylmethyl cation in presence of 46 equivalents of 1‐(methylphenylamino)cyclohexene. Using diarylmethyl cations of different electrophilicity E allows us to perform a comprehensive comparison of enamine nucleophilicity (N) on the basis of the depicted correlation equation. Enamines, commonly characterized as strong nucleophiles, show dramatically different reactivities. For a typical s value of 0.85, the nucleophilicity range from N = 16 to N = 4 corresponds to relative reactions times of one minute versus 20 000 years. A detailed report on the relationships between structure and nucleophilicities of enamines is given by H. Mayr et al. on p. 2209 ff.
Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism?
Authors: Cleeland Charles S. , Bennett Gary J. , Dantzer Robert , Dougherty Patrick M. , Dunn Adrian J. , Meyers Christina A. , Miller Andrew H. , Payne Richard , Reuben James M. , Wang Xin Shelley , Lee Bang‐Ning 
Published: May 2003

AbstractBACKGROUNDCancers and cancer treatments produce multiple symptoms that collectively cause a symptom burden for patients. These symptoms include pain, wasting, fatigue, cognitive impairment, anxiety, and depression, many of which co‐occur. There is growing recognition that at least some of these symptoms may share common biologic mechanisms.METHODSIn November 2001, basic and clinical scientists met to consider evidence for a cytokine‐immunologic model of symptom expression along with directions for future research.RESULTSThe characteristics of cytokine‐induced sickness behavior in animal models have much in common with those of symptomatic cancer patients. Sickness behavior refers to a set of physiologic and behavioral responses observed in animals after the administration of infectious or inflammatory agents or certain proinflammatory cytokines. In some cases, these responses can be prevented by cytokine antagonists. A combination of animal and human research suggests that several cancer‐related symptoms may involve the actions of proinflammatory cytokines.CONCLUSIONSBased on the similarities between cancer symptoms and sickness behavior, the authors discussed approaches to further test the implications of the relationship between inflammatory cytokines and symptoms for both symptom treatment and symptom prevention. Cancer 2003;97:2919–25. © 2003 American Cancer Society.DOI 10.1002/cncr.11382