bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol use disorder in patients after undergoing bariatric surgery
Authors: Oliveira Kátia Cristina , Santa-Cruz Fernando , Leão Luciana M. Souza , Kreimer Flávio , Ferraz Álvaro A. B. 
Published: January 2024

Abstract

Purpose: to evaluate the impact of bariatric surgery on the incidence of Alcohol Use Disorder (AUD) and depression during the postoperative period.
Methods: A prospective study was conducted, evaluating 68 patients who underwent either sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). The presence of AUD and depression was assessed both pre- and postoperatively. AUD assessment utilized the AUDIT-C score, while depression assessment employed the Beck Depression Inventory (BDI).
Results: The average age of the sample was 42.81 ± 9.28 years, with 85.3% being female. The meanfollow-up duration was 16.54 ± 7.41 months. In the preoperative assessment, 92.6% of the sample fell into the low-risk category for AUD according to the AUDIT-C. No statistically significant difference was observed between the RYGB and SG groups. Postoperatively, 89.7% of the sample was classified as low risk for AUD, with no significant differences comparedto the preoperative assessment. Regardingdepression, there was no significant difference between the pre- and postoperative periods for all patients. However, a notable trend towards a reduction in "severe depression" was observed in the postoperative period for patients undergoing SG (pre: 14.0% vs. post: 7.0%, p=0.013).
Conclusion: There is no significant difference in the presence of AUD and depression between pre- and postoperative assessments in patients who have undergone bariatric surgery.
Tributyrin displayed the potential nutrient mechanism by improving the growth of rumen bacteria of weaned lambs rather than via releasing butyric acid
Authors: Wang Yaxin , Chen Hua , An Ran , Ren Qingchang 
Published: January 2024

Abstract

Background
Tributyrin (TB), a feed additive, has been widely proved to display a benefit in stimulating the gastrointestinal tract development of livestock. For a long time, the benefit of TB is regarded as the prodrug of butyric acid. However, more and more studies recently showed that supplementing TB could enhance gastrointestinal microbiotas accompanied with the benefit. Here, we investigated the potential nutrient mechanism of TB based on in vitro ICE-6 intestinal epithelial cell culture in the absence of bacteria and in vivo experiment with involvement of rumen bacteria.
Results
In vitro experiment showed that butyric acid linearly increased both the late and early apoptotic ICE-6 intestinal epithelial cells, but similar effects were not observed in the same concentrations of TB. In vivo experiment showed that supplementing TB increased dry matter intake of lambs and daily retentions of dietary serine, cysteine and methionine. Besides, lambs fed TB had higher faecal excretions of C12:0, C13:0, C18:2n6c, C18:3n3 and C20:0 but lower C16:1n9c, C17:0 and C18:1n9c compared with that of lambs provided no TB. The correlation analysis showed that daily retentions of dietary serine, methionine and cysteine were positively correlated with the relative abundances of ruminal Fibrobacter, Butyrivibrio, Bifidobacterium and Firmicutes, respectively. In addition, the relative abundance of rumen Clostridium was positively correlated with the daily decreases of C6:0, C18:1n9c, C18:2n6c and the daily increases of C13:0, C15:0 and C18:0, respectively. Meanwhile, the relative abundance of rumen Fibrobacter was positively correlated with the daily decreases of C6:0, C16:0, C18:1n9c, C18:2n6c, C18:3n3, C20:0, C22:0, C24:0 while was negatively correlated with the daily increases of C14:0, C15:0, C16:1n9c and C18:0, respectively. Furthermore, the relative abundance of rumen Butyrivibrio was negatively correlated with the daily increases of C14:0, C16:1n9c, C17:0 while was positively correlated with the daily decreases of C16:0, respectively.
Conclusions
Our both in vitro and in vivo experiments revealed that supplementing TB could display the nutrient mechanism by improving the growth of rumen bacteria rather than via releasing butyric acid.
Synergistic inhibition of APE1 redox activity and ATM activation sensitizes osteosarcoma cells to ionizing radiation by inducing ferroptosis
Authors: Xiao Han-xi , Jiang Nan , Zhang Hong-bin , Wang Shuai , Pi Qin , Chen Hua-wei , He Xuan , Luo Wei , Deng Youcai , Lu Yonghui , Zhong Zhaoyang 
Published: January 2024

Abstract
The resistance of osteosarcoma (OS) to ionizing radiation (IR) is a great obstacle for its radiotherapy. Apurinic/apyrimidinic endonuclease-reduction/oxidation factor 1 (APE1/Ref-1) is a multifunctional protein with DNA repair and reduction/oxidation (redox) activities. Our previous study revealed a role of APE1 in OS radioresistance, but whether the redox activity of APE1 is involved is not clear. Moreover, APE1 has recently been shown to regulate ataxia-telangiectasia mutated(ATM) activation, which is an initiator of DNA damage response and mediates radioresistance in several other cancers. Although their role in radioresistance of OS remains to be studied, the possible crosstalk between APE1 redox activity and ATM activation may complicate the mechanism of OS radioresistance. Our results revealed that IR increased APE1 expression and ATM activation in OS cells, and APE1 directly regulated ATM activation by its redox activity. The synergetic administration of APE1 redox inhibitor and ATM inhibitor effectively sensitized OS cells to IR. Further study revealed that ferroptosis mediated the radiosensitization of OS cells induced by the combined inhibition of APE1 redox activity and ATM activation. Moreover, simultaneous treatment withthese two inhibitors, rather than each alone, drastically decreased the expression of their common targeting transcription factor p53. Taken together, our results demonstrated that APE1 redox activity and ATM activation as well as their crosstalk played important roles in the resistance of OS to irradiation, and synergetic inhibition of APE1 redox activity and ATM activation sensitized OS cells to IR by inducing ferroptosis, which providesa promising strategy for OS radiotherapy.
Targeting TFF3 in obstructive airway diseases: a computational approach to novel therapeutics
Authors: Shahriary Alireza , Sisakht Mohsen , Arabfard Masoud , Behmard Esmaeil , Najafi Ali 
Published: January 2024

Abstract
Background
Airway remodeling, a hallmark of chronic obstructive pulmonary disease (COPD) and Mustard lung disease, is influenced by the Trefoil Factor 3 (TFF3). This study sought to pinpoint a compound with minimal toxicity that can effectively suppress TFF3 expression and activity.
Methods and Results
We employed an integrative approach, combining gene expression analysis, molecular docking, and molecular dynamics simulations, to identify potential TFF3 inhibitors. The biological safety of these compounds was ascertained using a sophisticated deep neural network model. Of the compounds assessed, eight manifested a significant reduction in TFF3 expression, with binding affinities (ΔG) ranging from − 7 to -9.4 kcal/mol. Notably, Genistein emerged as the frontrunner, showcasing potent TFF3 downregulation, minimal toxicity, and a robust inhibitory profile as evidenced by molecular dynamics simulations.
Conclusion
Genistein holds promise as a therapeutic agent for TFF3-mediated conditions, including mustard lung disease. Its potential to address the current therapeutic gaps is evident, but its clinical utility necessitates further in vitro and in vivo validation.
The association between intergenerational financial support and multidimensional health poverty among Chinese older adults: analysis of data from the China Health and Retirement Longitudinal Study (CHARLS)
Authors: Cai Yue , Xue Yang , Yao Yuanyuan , Jing Zhengyue , Xue Yu 
Published: January 2024

Abstract
Background
Previous studies have indicated that intergenerational financial support was associated with health poverty among older adults, but few studies have accounted for multidimensional characteristics of health. This study aims to investigate the incidence of multidimensional health poverty among older adults, and explore the effect of intergenerational financial support on the multidimensional health poverty among older adults in China.
Methods
This study was based on the data from China Health and Retirement Longitudinal Study (CHARLS) 2018. A total of 3,937 adults aged 60 years and older were included in this study. Multidimensional health poverty was measured through three dimensions: physical health poverty, mental health poverty, and social health poverty, and the Alkire-Foster (AF) method was used to evaluate the incidence of multidimensional health poverty among older adults. Logistic regression models and OLS regression models were employed to explore the association between intergenerational financial support and multidimensional health poverty among older adults.
Results
The index of multidimensional health poverty among older adults was 0.365, and the incidence of multidimensional health poverty was 63.3% at the threshold of 1/3. Intergenerational financial support was associated with multidimensional health poverty among older adults (OR = 0.880, P < 0.001). Furthermore, intergenerational financial support had a negative impact on physical health poverty (Coef. = -0.002, P < 0.05), mental health poverty (Coef. = -0.008, P < 0.01), and social health poverty (Coef. = -0.009, P < 0.01), respectively.
Conclusions
This study demonstrates that the incidence of multidimensional health poverty was higher among older adults, and intergenerational financial support was negatively associated with multidimensional health poverty. Policymakers should explore home-based interventions to reduce the incidence of multidimensional health poverty among older adults.
Bridging Hearts and Nurturing Bonds: A Holistic Exploration of Postpartum Depression, Social Support, and Breastfeeding Self-Efficacy among Women in Gujarat, India
Authors: Surati Bhumika , M Yogesh , Munshi Raza , Vamja Roshni 
Published: January 2024

Abstract
Background
Postpartum depression and breastfeeding practices are interlinked maternal health issues requiring greater attention in India.
Objectives
This study examined associations between postpartum depression, social support, breastfeeding attitudes, and self-efficacy among postpartum women in Gujarat, India.
Materials and Methods
In this cross-sectional study, 400 postpartum women were recruited from a tertiary hospital. Depression was assessed using the Edinburgh Postnatal Depression Scale. Social support, breastfeeding attitudes, and self-efficacy were measured using validated scales. Logistic regression models were constructed to identify predictors of probable depression.
Results
The prevalence of probable postpartum depression was 28% (112/400). Lower socioeconomic status (upper lower class AOR 2.6, 95% CI 1.2–5.5) and lower social support (per 1 unit increase AOR 0.97, 95% CI 0.94–0.99) were significant independent risk factors for probable depression in multivariate modeling. There were negative correlations between depression scores and social support (r=-0.35, p < 0.001), breastfeeding attitudes (r=-0.21, p < 0.001), and self-efficacy (r=-0.42, p < 0.001). Social support and breastfeeding attitudes showed positive correlations with breastfeeding self-efficacy (r = 0.61 and r = 0.33 respectively, p < 0.001)
Conclusion
The key findings indicate lower socioeconomic status and social support as major risk factors for postpartum depression among women in Gujarat. Routine psychosocial assessment and support are recommended in postnatal care. Social support and positive attitudes may enable higher breastfeeding self-efficacy. The results highlight the need for targeted interventions to address depression and improve breastfeeding practices.
The Impact of Parental Electronic Health Literacy on Disease Management and Outcomes in Pediatric Type 1 Diabetes Mellitus: Cross-Sectional Clinical Study
Authors: Hölgyesi Áron , Luczay Andrea , Tóth-Heyn Péter , Muzslay Eszter , Világos Eszter , Szabó Attila J , Baji Petra , Kovács Levente , Gulácsi László , Zrubka Zsombor , Péntek Márta 
Published: January 2024

Background
Despite the growing uptake of smart technologies in pediatric type 1 diabetes mellitus (T1DM) care, little is known about caregiving parents’ skills to deal with electronic health information sources.

Objective
We aimed to assess the electronic health literacy of parents caring for children with T1DM and investigate its associations with disease management and children’s outcomes.

Methods
A cross-sectional survey was performed involving 150 parent-child (8-14 years old with T1DM) dyads in a university pediatric diabetology center. Parents’ electronic health literacy (eHealth Literacy Scale [eHEALS]), general health literacy (Chew questionnaire and Newest Vital Sign [NVS]), and attitudes toward T1DM care (Parental Self-Efficacy Scale for Diabetes Management [PSESDM] and Hypoglycemia Fear Survey [HFS]) were investigated. Children’s treatment, HbA1c level, and quality of life (Pediatric Quality of Life Inventory Diabetes Module [PedsQL Diab] and EQ-5D-Y-3L) were assessed. Multiple linear regression analysis was performed to investigate the determining factors of 6-month average HbA1c.

Results
Of the 150 children, 38 (25.3%) used a pen, 55 (36.7%) used a pen plus a sensor, 6 (4.0%) used an insulin pump, and 51 (34.0%) used an insulin pump plus a sensor. Parents’ average eHEALS score (mean 31.2, SD 4.9) differed significantly by educational level (P=.04) and the children’s treatment (P=.005), being the highest in the pump + sensor subgroup. The eHEALS score showed significant Pearson correlations with the Chew score (r=−0.45; P<.001), NVS score (r=0.25; P=.002), and PSESDM score (r=0.35; P<.001) but not with the children’s HbA1c (r=−0.143; P=.08), PedsQL Diab (r=−0.0002; P>.99), and EQ-5D-Y-3L outcomes (r=−0.13; P=.12). Regression analysis revealed significant associations of the child’s HbA1c level with sex (β=0.58; P=.008), treatment modality (pen + sensor: β=−0.66; P=.03; pump + sensor: β=−0.93; P=.007), and parents’ self-efficacy (PSESDM; β=−0.08; P=.001).

Conclusions
Significantly higher parental electronic health literacy was found in T1DM children using a glucose sensor. The electronic health literacy level was associated with parents’ diabetes management attitude but not with the child’s glycemic control. Studies further investigating the role of parental electronic health literacy in T1DM children managed at different levels of care and the local context are encouraged.
Efficacy of BrighterSide, a Self-Guided App for Suicidal Ideation: Randomized Controlled Trial
Authors: Josifovski Natasha , Torok Michelle , Batterham Philip , Wong Quincy , Beames Joanne R , Theobald Adam , Holland Sarah , Huckvale Kit , Riley Jo , Cockayne Nicole , Christensen Helen , Larsen Mark 
Published: January 2024

Abstract

Background
Self-guided digital interventions can reduce the severity of suicidal ideation, although there remain relatively few rigorously evaluated smartphone apps targeting suicidality.

Objective
This trial evaluated whether the BrighterSide smartphone app intervention was superior to a waitlist control group at reducing the severity of suicidal ideation.

Methods
A total of 550 adults aged 18 to 65 years with recent suicidal ideation were recruited from the Australian community. In this randomized controlled trial, participants were randomly assigned to receive either the BrighterSide app or to a waitlist control group that received treatment as usual. The app was self-guided, and participants could use the app at their own pace for the duration of the study period. Self-report measures were collected at baseline, 6 weeks, and 12 weeks. The primary outcome was severity and frequency of suicidal ideation, and secondary outcomes included psychological distress and functioning and recovery. Additional data were collected on app engagement and participant feedback.

Results
Suicidal ideation reduced over time for all participants, but there was no significant interaction between group and time. Similar improvements were observed for self-harm, functioning and recovery, days out of role, and coping. Psychological distress was significantly lower in the intervention group at the 6-week follow-up, but this was not maintained at 12 weeks.

Conclusions
The BrighterSide app did not lead to a significant improvement in suicidal ideation relative to a waitlist control group. Possible reasons for this null finding are discussed.
Development and validation of the Adherence to Asthma Medication Questionnaire (AAMQ)
Authors: Nassar Razan I. , Saini Bandana , Obeidat Nathir M. , Basheti Iman A. 
Published: January 2024

Background: Adherence to medication is the cornerstone to
achieve the best treatment outcome. Pharmacists are healthcare
professionals found in pivotal positions to assess asthmatic patient’s
adherence to medication. A brief, reliable, and valid measure of patient
adherence is useful to enable the pharmacists to deliver that vital
service. This study aims to develop a reliable and valid adherence
assessment tool for asthmatic patients. Methods: The Adherence
to Asthma Medication Questionnaire (AAMQ-13) was developed based on an
extensive literature review, followed by applying the Delphi technique,
and then it was pilot-tested by 55 patients. The final AAMQ-13 was
completed by 213 patients. Psychometric evaluation was assessed
including reliability, criterion validity, and construct validity.
Results: The AAMQ-13 is a feasible 13 item questionnaire, as it
can be completed within an average of two minutes. It has high internal
validity (Cronbach’s alpha= 0.87). Criterion-concurrent validity was
established by comparing the AAMQ-13 to the Test of the Adherence to
Inhaler (TAI) and the pharmacy refill records. Criterion-convergent
validity was established by comparing the AAMQ-13 to the Asthma Control
Test (ACT) questionnaire and the Positive Health Behaviors Scale (PHBS).
Construct validity was established through AAMQ-13 factor analysis which
revealed two factors explaining 51.76% of the variance.
Conclusion: The AAMQ-13 is a reliable and valid questionnaire
with several desirable characteristics as it has a high internal
validity, good criterion validity, and strong construct validity. The
AAMQ-13 is a suitable questionnaire that can identify non-adherent
patients and reveal the reasons behind their non-adherence (intentional
or unintentional non-adherence).
Visual Appearance Features of Sign Language Avatars
Authors: ATASOY Murat , ŞILBIR Lokman , FİŞ ERÜMİT Semra , BAHÇEKAPILI Ekrem , YILDIZ Adil , KARAL Hasan 
Published: January 2024

Purpose: 3D Sign language avatars communicate with individuals in digital environments, like educational agents. However, while designing educational agents, the target group comes to the fore. In the literature, it is seen that the visual appearance features that should be considered in the creation of avatar designs are specified in diverse ways. Main goal of this study is to evaluate the sign language avatars’ visual appearance features in the literature and applications within the framework of educational agents.
Design/Methodology/Approach: In this study, seventy-nine different sign language avatars’ images were evaluated within the framework of visual appearance features. Seven category and fifteen features were evaluated by four field experts through focus group discussions.
Findings: In the evaluation, seven important categories were determined in avatar visual appearance. It is seen that the eye and head designs of avatars are generally designed in normal size. If an iconic design process is being carried out, eye, head, arm, and finger visual appearances should be designed larger than normal. If a realistic design process is carried out, eye, head, finger, palm, and arm visual appearances should be designed in normal sizes.
Highlights: When designing sign language avatars, the upper body should be visible. In addition, what the target group will be affects the gender and iconicity of the avatar. Avatar should be designed simply so that individuals do not overload their visual channel. Also, different visual appearance features should be considered for iconic or realistic avatars. In addition to this, it is recommended that the hand and head sizes should be bigger than normal in order to understand the signs and non-manual signs more clearly.
THE INTEGRATION OF CHESS AND MATHEMATICS AS A PREREQUISITE FOR ENHANCING THE QUALITY OF EDUCATION
Authors: Hovhannisyan Knarik , Misakyan Samvel , Sargsyan Vahan , Muradyan Rima 
Published: January 2024

ABSTRACT
Numerous studies have proven that chess indicates a player's mental skills and ability to think. The goal of our study is to explore the process of learning chess in elementary school in the context of the integration of mathematics and chess, as well as to develop and offer methodological suggestions that will improve the efficiency of understanding mathematics. By solving non-standard "chess" problems in math classes and extracurricular math lessons, the link between chess and the development of spatial thinking can help to foster the development of a unique capacity to operate in the mind.
Menntun eða úrræði?
Authors: Magnúsdóttir Berglind Rós , Svavarsson Helgi Þ. 
Published: January 2024

Þessi grein sprettur upp úr heildarendurskoðun á framhaldsfræðslukerfinu hér á Íslandi sem hófst í janúar 2023. Skoðað er hvernig stjórnvöld á Íslandi hafa skilgreint markmið fullorðinsfræðslu í frumvörpum sínum og lögum allt frá 1974. Í framhaldi af því er rýnt í framtíðarsýn UNESCO, OECD og íslenskra stjórnvalda varðandi menntun fullorðinna og að lokum velt upp hvernig má nýta þessar greiningar og stefnuskjöl til markvissrar endurskoðunar á gildandi lögum um framhaldsfræðslu (nr. 27/2010) sem unnið er að um þessar mundir.
Greining frumvarpanna leiðir í ljós að hugmyndafræði almennrar menntunar með víða skírskotun til fjölbreyttrar menntunar fyrir alla hefur æ meir vikið fyrir aukinni tæknihyggju og skólahyggju sem beinist fyrst og fremst að þröngum hópi fullorðinna einstaklinga með stutta skólagöngu að baki. Einnig kemur fram að núverandi lög um framhaldsfræðslu ná ekki að takast á við þær áskoranir og þrástef sem koma fram í fjölþjóðlegum framtíðarstefnuskjölum OECD og UNESCO.
Greinin endar á því að leggja fram tillögur um inntak markmiðsgreinar þar sem gætt er að jafnvægi milli ólíkra þátta og að þróa markmið sem eiga rætur sínar í almennri menntun, skólahyggju og tæknihyggju og efla fólk til samfélagslegrar, borgaralegrar og atvinnutengdrar þátttöku. Auk þess er lögð áhersla á að tekið verði tillit til framtíðaráskorana sem eru þrástef í fjölþjóðlegum stefnuskjölum og fundið aukið jafnvægi milli áherslunnar á opinbert líf og einkalíf í inntaki námsins.