bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Systemic Immune-Inflammation Index(SII) and coronary artery lesions in Kawasaki Disease
Authors: Huang Tiantuo , Peng Qi , Zhang Yiyue , Zhu Zaifu , Fan Xiaochen 
Published: October 2023

Abstract
Coronary artery lesions(CALs) are the most common complications of Kawasaki disease(KD) and play a crucial role in determining the prognosis of the disease. Consequently, the early identification of children with KD who are at risk of developing coronary artery damage is vitally important. We sought to investigate the relationship between the Systemic Immune-Inflammation Index (SII) and CALs in patients with KD and to assess its predictive value. We carried out a retrospective review and analysis of medical records for KD patients treated at the First Affiliated Hospital of Anhui Medical University between January 2017 and January 2023. We utilized single-variable tests, binary logistic regression analysis, ROC curve analysis, restricted cubic spline tests, and curve fitting to evaluate the association between SII and CALs. In our study, 364 patients were included, with 63 (17.3%) presenting with CALs at the time of admission. The binary logistic regression analysis indicated that SII was a significant risk factor for CALs at admission, evident in both unadjusted and models adjusted for confounders. The ROC curve analysis revealed an AUC (Area Under the Curve) value of .789 (95%CI .723- .855, P < .001) for SII's predictive ability regarding CALs at admission. A consistent positive linear relationship between SII and the risk of CALs at admission was observed in both the raw and adjusted models. Our research findings suggest that SII serves as a risk factor for CALs and can be used as an auxiliary laboratory biomarker for predicting CALs.
L-Theanine inhibits cancer stem cell-mediated chemoresistance in lung cancer by regulating STAT3/NOTCH1-BMAL1 signaling
Authors: Jin Wenjing , Su Ling , You Hong , Dong Zhouyu , Liu Min , Zhou Chao 
Published: October 2023

Abstract
Cancer stem cells play crucial roles in the development of cancer chemoresistance. L-Theanine, a nonproteinogenic amino acid derived from green tea, is gaining more and more attentions in reversing cancer drug resistance. However, its roles in development of lung cancer chemoresistance is still unknown. To investigate the effects of L-Theanine on chemoresistance and explore its underlying mechanism in lung cancer, we performed a panel of experiments in vitro combined with RNA-seq analysis and demonstrated L-Theanine improved the chemoresistance to cisplatin (cis-diamminedichloroplatinum; DDP) and inhibited stemness of DDP-resistant lung cancer cells but not non-resistant lung cancer cells and STAT3/NOTCH1 signaling was a potential dominant process involved in L-Theanine improving chemoresistance in DDP-resistant lung cancer. Mechanistically, L-Theanine impedes DDP-resistant lung cancer cells migration and activation via regulating the expression of STAT3/NOTCH1/BMAL1 signaling-induced stemness markers, reducing the migration and proliferation of DDP-resistant lung cancer cells as well as inhibiting drug resistance-related genes expression in DDP-resistant lung cancer cells. In addition, combination of L-Theanine and Stat3 blockade improved synergistically the chemoresistance in DDP-resistant lung cancer. In summary, L-Theanine improved chemoresistance in chemoresistant lung cancer through regulating STAT3/NOTCH1/BMAL1 signaling, reducing stemness and finally inhibiting the migration of DDP-resistant lung cancer cells. The finding might provide the research evidence for therapeutic options of reversing chemoresistance in lung cancer.
Virtual reality as an aged care technology – opportunities and limitations from a qualitative study
Authors: Felber Nadine Andrea , Mihailov Emilian , Wangmo Tenzin 
Published: October 2023

Abstract

The metaverse, a virtual, three-dimensional and interactive world that is accessible through virtual reality (VR) technology, is gaining interest in healthcare and medical research. VR, as its precursor, already offers opportunity for healthcare itself, due to its capabilities to overcome distances, create safe, customized environments and allow immersive, powerful experiences. Older adults, who often suffer from reduced mobility, could thus greatly benefit from VR. This qualitative study explores the perceptions of older adults and their caregivers, formal and informal, on VR and its potential use in aged care. The study reveals that all stakeholder groups foresee potential of VR as an entertaining and therapeutic technology, but that they also worry about VRs’ impact on loneliness, the cognitive capabilities needed to use it, as well as its safety for older adults. Our study identifies clear opportunities for VR technology in aged care and points to important prejudices that need to be dismantled before VR will be widely adopted as a technology in aged care.
Experienced Meditators Show Enhanced Interaction between Brain and Heart Functioning
Authors: Wang Michael Yufeng , Corcoran Andrew W , McQueen Brittany , Freedman Gabrielle , Humble Gregory , Fitzgibbon Bernadette Mary , Fitzgerald Paul B , Bailey Neil W 
Published: October 2023

Abstract
Objectives
Regulation of the heart by the brain is a vital function of the autonomic nervous system (ANS), and healthy ANS function has been linked to a wide range of well-being measures. Although there is evidence of mindfulness-meditation related changes to brain functioning and heart functioning independently, few studies have examined the interaction between the brain and heart in experienced meditators.
Methods
This study compared measures of the brain-heart relationship between 37 experienced meditators and 35 non-meditators (healthy controls) using three different analysis methods: 1) the heartbeat evoked potential (HEP; thought to reflect neural sensitivity to interoceptive feedback); 2) the relationship between fronto-midline theta neural oscillations (fm-theta) and the root mean square of successive differences (RMSSD) in electrocardiogram activity (an estimate of vagally-mediated heart rate variability); and 3) the correlation between heart rate wavelet entropy and electroencephalographic wavelet entropy – a measure of signal complexity.
Results
The HEP analysis indicated that meditators showed a more central-posterior distribution of neural activity time-locked to the heartbeat (p < .001, partial η² = .06) than controls. A significant positive relationship was also found between fm-theta and RMSSD in meditators (F(2,34) = 4.18, p = .02, R2 = .2) but not controls. No significant relationship was found between EEG entropy and ECG entropy in either group.
Conclusions
The altered distribution of evoked neural activity, and the correlation between brain and heart biomarkers of vagal activity suggests greater neural regulation and perhaps greater sensitivity to interoceptive signals in experienced meditators.
Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters
Authors: Bonk Sarah , Eszlari Nora , Kirchner Kevin , Gezsi Andras , Garvert Linda , Koukkanen Mikko , Cano Isaac , Grabe Hans J. , Antal Peter , Juhasz Gabriella , Auwera Sandra Van der 
Published: October 2023

Abstract

Background:
Major depressive disorder (MDD) is considerably heterogeneous in terms of comorbidities, which may hamper the disentanglement of its biological mechanism. In a previous study, we classified the lifetime trajectories of MDD-related multimorbidities into seven distinct clusters, each characterized by unique genetic and environmental risk-factor profiles. The current objective was to investigate genome-wide gene-by-environment (G×E) interactions with childhood trauma burden, within the context of these clusters.
Methods:
We analyzed 76,856 participants and 3,875,386 single-nucleotide polymorphisms (SNPs) of the UK Biobank database. Childhood trauma burden was assessed using the Childhood Trauma Screener (CTS). For each cluster, Plink 2.0 was used to calculate SNP×CTS interaction effects on the participants’ cluster membership probabilities. We especially focused on the effects of 31 candidate genes and associated SNPs selected from previous G×E studies for childhood maltreatment’s association with depression.
Results:
At SNP-level, only the high-multimorbidity Cluster 6 revealed a genome-wide significant SNP rs145772219. At gene-level, LDLRAD4 was genome-wide significant for the low-multimorbidity Cluster 1 and C6orf89and TAAR2 for the high-multimorbidity Cluster 7. Regarding candidate SNPs for G×E interactions, individual SNP results could be replicated for specific clusters. The candidate genes DRD2 (Cluster 1), and DBH and MTHFR (both Cluster 5), and TPH1(Cluster 6) survived multiple testing correction.
Limitations:
CTS is a short retrospective self-reported measurement. Clusters could be influenced by genetics of individual disorders.
Conclusions:
The first G×E GWAS for MDD-related multimorbidity trajectories successfully replicated findings from previous G×E studies related to depression, and revealed risk clusters for the contribution of childhood trauma.
Revitalizing Worn-Out Overdenture Attachments in One-Piece Implant Cases using Silicone Matrix System: A Case Report
Authors: Dr Anamika Abraham  , Dr. Angleena Y Daniel  , Dr. Achsah Ann Thomas  
Published: October 2023

The case report discusses the use of a silicone matrix system for salvaging worn-out overdenture attachments in one-piece implant cases. It highlights the effectiveness of this technique and presents a detailed case study. One-piece or single-piece implant systems, where the intraosseous and abutment portions with the stud attachments consist of one unit, do not allow changing the worn-out abutment individually if required, thus ruling out any further use of implant and abutment once the attachment component faces extensive irreversible wearing. The ‘Retention. Sil’ – an additional curing elastomeric material in salvaging worn-out attachments of one-piece implants, emphasizes the revitalization process and effective use as an attachment for implant-retained overdenture, thereby extending the clinical use of one-piece implants and avoiding extensive invasive procedures in geriatric patients.
Experimental and theoretical analysis of solar still with solar pond for enhancing the performance of sea water desalination
Authors: Yuvaperiyasamy M. , Senthilkumar N. , Deepanraj B. 
Published: October 2023

Abstract

In a practical scenario, only a modest amount of distilled water can be generated each day by a basic solar still with a single basin. Fin-type solar ponds, fin-type solar stills, and integrated fin-type solar stills with finned ponds are investigated. The theoretic performance and experimental studies on the proposed systems were carried out in Pongalur near Tirupur (10.9729° N, 77.3698° E), a region with a latitude of 10° north. Single basin solar still (SBSS), single basin solar still with fin, single basin solar still with pond, single basin solar still with finned pond, and integrated single basin fin-type solar still with a finned solar pond were developed. Adding fins to the small solar pond enhanced the thermal performance of SBSS, by increasing the daily water collection. The pace at which heat is transmitted from the basin to water has risen due to the fins. According to this study, the amount of water collected by single basin solar still with fin, single basin solar still with finned pond, and integrated single basin solar still with fins and finned pond grew by 46, 48, and 52% for each of these systems.
Nitrogen removal performance of aerobic denitrifying bacteria enhanced by an iron-anode pulsed electric field
Authors: Wang Fan , Bo Zhang , Dong Xiaonan , Zhou Xingxing , Hu Xiaomin 
Published: October 2023

Abstract

Pulsed electric field (PEF) technology has attracted considerable attention because it can efficiently treat pollutants that are difficult to degrade. In this study, a PEF system using iron as the electrode was constructed to investigate the effect of PEF–Fe on the growth and metabolism of aerobic denitrifying bacteria and the effectiveness of wastewater nitrogen removal. The chemical oxygen demand, NO3-–N and nitrate removal rates were 98.93%, 97.60% and 24.40 mg·L−1·h−1, respectively, under optimal conditions. As confirmed in this study, PEF–Fe could improve the key enzyme activities of W207-14. Scanning electron microscopy revealed that the surface of PEF–Fe-treated W207-14 was intact and smooth without any irreversible deformation. Flow cytometry combined with fluorescence staining analysis also confirmed reversible electroporation on the cell membrane surface of PEF–Fe-treated W207-14. Differentially expressed gene enrichment analysis showed that PEF–Fe activated the transmembrane transport function of ATP-binding cassette transporte (ABC) transport proteins and enhanced the cell membrane permeability of aerobic denitrifying bacteria. The significant differential expression of iron–sulphur cluster proteins facilitated the regulation of electron transport and maintenance of the dynamic balance of iron ions within the PEF–Fe system.
IMPLICAÇÕES DA CONTRARREFORMA DO ENSINO MÉDIO NA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA BRASILEIRA
Authors: De Sousa Sampaio Fabrício 
Published: October 2023

A contrarreforma educacional em curso objetiva reorganizar os currículos e direciona a educação brasileira para determinado sentido e finalidade capitaneados pelo empresariado do país e pelos organismos internacionais. Partindo do questionamento sobre os principais efeitos que a atual contrarreforma educacional possa reverberar na educação profissional e tecnológica brasileira, esta pesquisa qualitativa bibliográfica e documental objetiva identificar e analisar os efeitos dessa contrarreforma na estruturação, organização e finalidade da EPT. Dentre os resultados parciais, podemos afirmar que a implementação da recente contrarreforma recupera a dualidade e a fragmentação do ensino médio, objetivadas por reformas anteriores e, fundamentalmente na EPT, desmonta o ideário da formação humana integral através da: ressignificação, hibridismo e esvaziamento de conceitos importantes para a defesa dessa modalidade; a educação para o empreendedorismo e a precarização da formação docente ao permitir o notório saber.
Using Theories, Models, and Frameworks to Inform Implementation Cycles of Computerized Clinical Decision Support Systems in Tertiary Health Care Settings: Scoping Review
Authors: Fernando Manasha , Abell Bridget , Tyack Zephanie , Donovan Thomasina , McPhail Steven M , Naicker Sundresan 
Published: October 2023

Background
Computerized clinical decision support systems (CDSSs) are essential components of modern health system service delivery, particularly within acute care settings such as hospitals. Theories, models, and frameworks may assist in facilitating the implementation processes associated with CDSS innovation and its use within these care settings. These processes include context assessments to identify key determinants, implementation plans for adoption, promoting ongoing uptake, adherence, and long-term evaluation. However, there has been no prior review synthesizing the literature regarding the theories, models, and frameworks that have informed the implementation and adoption of CDSSs within hospitals.

Objective
This scoping review aims to identify the theory, model, and framework approaches that have been used to facilitate the implementation and adoption of CDSSs in tertiary health care settings, including hospitals. The rationales reported for selecting these approaches, including the limitations and strengths, are described.

Methods
A total of 5 electronic databases were searched (CINAHL via EBSCOhost, PubMed, Scopus, PsycINFO, and Embase) to identify studies that implemented or adopted a CDSS in a tertiary health care setting using an implementation theory, model, or framework. No date or language limits were applied. A narrative synthesis was conducted using full-text publications and abstracts. Implementation phases were classified according to the “Active Implementation Framework stages”: exploration (feasibility and organizational readiness), installation (organizational preparation), initial implementation (initiating implementation, ie, training), full implementation (sustainment), and nontranslational effectiveness studies.

Results
A total of 81 records (42 full text and 39 abstracts) were included. Full-text studies and abstracts are reported separately. For full-text studies, models (18/42, 43%), followed by determinants frameworks (14/42,33%), were most frequently used to guide adoption and evaluation strategies. Most studies (36/42, 86%) did not list the limitations associated with applying a specific theory, model, or framework.

Conclusions
Models and related quality improvement methods were most frequently used to inform CDSS adoption. Models were not typically combined with each other or with theory to inform full-cycle implementation strategies. The findings highlight a gap in the application of implementation methods including theories, models, and frameworks to facilitate full-cycle implementation strategies for hospital CDSSs.
Factors Influencing the Answerability and Popularity of a Health-Related Post in the Question-and-Answer Community: Infodemiology Study of Metafilter
Authors: Yang Jinqing , Liu Zhifeng , Wang Qicong , Lu Na 
Published: October 2023

Background
The web-based health question-and-answer (Q&A) community has become the primary and handy way for people to access health information and knowledge directly.

Objective
The objective of our study is to investigate how content-related, context-related, and user-related variables influence the answerability and popularity of health-related posts based on a user-dynamic, social network, and topic-dynamic semantic network, respectively.

Methods
Full-scale data on health consultations were acquired from the Metafilter Q&A community. These variables were designed in terms of context, content, and contributors. Negative binomial regression models were used to examine the influence of these variables on the favorite and comment counts of a health-related post.

Results
A total of 18,099 post records were collected from a well-known Q&A community. The findings of this study include the following. Content-related variables have a strong impact on both the answerability and popularity of posts. Notably, sentiment values were positively related to favorite counts and negatively associated with comment counts. User-related variables significantly affected the answerability and popularity of posts. Specifically, participation intensity was positively related to comment count and negatively associated with favorite count. Sociability breadth only had a significant impact on comment count. Context-related variables have a more substantial influence on the popularity of posts than on their answerability. The topic diversity variable exhibits an inverse correlation with the comment count while manifesting a positive correlation with the favorite count. Nevertheless, topic intensity has a significant effect only on favorite count.

Conclusions
The research results not only reveal the factors influencing the answerability and popularity of health-related posts, which can help them obtain high-quality answers more efficiently, but also provide a theoretical basis for platform operators to enhance user engagement within health Q&A communities.
Dragon fruit versus soybean: impact on blood glucose of diabetic patients
Authors: Srywahyuni Ade , Amelia Dona , Merianti Liza 
Published: October 2023

Introduction: Diabetes Mellitus (DM) is a serious problem with a sharp increase in incidence. DM can attack almost all groups of people around the world. The number of DM sufferers continues to increase from year to year because of today's human lifestyle which tends to rarely move and unhealthy eating patterns. Objectives: The purpose of this study was to compare the effect of giving soy milk and red dragon fruit on fasting blood glucose levels in type 2 diabetes mellitus patients. Methods: The type of research used was quasy experiment with pre-test-post-test design with two group comparison treatment. The research subjects were Type 2 Diabetes Mellitus sufferers in the working area of the Guguk Panjang Health Center in Bukittinggi City with a total sample of 54 people, divided into an intervention group of 18 who were given 200 grams of red dragon fruit for 7 days, 18 were given 50 grams of soy milk dissolved in 250 ml of water and 18 people in the control group. Results: The results showed that the P-value <0.05 (P=0.035) and the t-value (2.198) ≥ t-table (2.110), meaning that there is an effect of giving soy milk on blood glucose levels in Type 2 Diabetes Mellitus sufferers. There is an effect of giving red dragon fruit on fasting blood sugar levels and blood pressure where the p value was obtained for fasting sugar levels P = 0.018 (p <0.05) and the t count (2.198) was greater than t table (2.11). The results of the ANOVA test showed that the effectiveness of giving red dragon fruit was more effective with an average decrease in blood sugar of 32.56, compared to the effectiveness of giving soy milk with an average decrease in blood sugar of 22.50. Conclusions: In conclusion, red dragon fruit is more effective in lowering blood sugar levels and blood pressure in type 2 diabetes mellitus patients with hypertension, because the content of red dragon fruit can repair damaged pancreatic cells.
Clinical and etiological features of peadiatric facial neuropathy and their role in predicting outcomes
Authors: Irikova M. A. , Skripchenko E. Yu. , Voitenkov V. B. , Marchenko N. V. , Skripchenko N. V. , Goleva O. V. , Petrov I. B. 
Published: October 2023

The aim: to characterize the clinical and etiological features of facial palsy (FP) in children of different ages at the present stage and their correlation with the outcome and duration of the disease.Materials and methods: the data of 68 children with FP were obtained. The neurological examination with an assessment of the level of facial nerve damage and the severity of FP using the House-Brackmann scale (HB), the concomitant symptoms and the etiological verification of a possible infectious agent were performed to all children. Also, their correlation with the outcomes and duration of the disease were assessed.Results: in the etiological structure infectious FP are more common in children under 12 years of age, with a predominance of herpesviruses and enteroviruses, whereas, more than half of the cases in children over the age of 12 years are idiopathic (Bell’s palsy), less often herpesviruses. A longer course and the probability of an unfavorable are significantly more often observed in the group of children under 12 years of age. There was also a significant correlation between the severity of FP according to HB with the outcomes and duration of the disease.Conclusion: The results confirm the importance and necessity of laboratory confirmation of a possible etiological agent associated with the development of FP. The severity of FP doesn’t depend on the age of the child, but correlates with the outcome and duration of the disease, more less with the synkinesia. A promising direction for further research is to clarify the climatic factors affecting the incidence of FP.