bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of body mass index on maternal and perinatal outcomes in COVID‐19 infection during pregnancy and postpartum: Secondary analysis from the REBRACO cohort study
Authors: Sardinha Thais G. , Lajos Giuliane J. , Souza Renato T. , Cecatti Jose G. , Luz Adriana G. , Oppermann Maria Lúcia R. , Pacagnella Rodolfo C. , Ribeiro‐Do‐Valle Carolina C. , Nobrega Guilherme M. , Griggio Thayna B. , Charles Charles M. , Silveira Carla , Miele Maria J. , Tedesco Ricardo P. , Fernandes Karayna G. , Martins‐Costa Sérgio Ha , Peret Frederico Ja , Feitosa Francisco E. , Traina Evelyn , Cunha Filho Edson V. , Vettorazzi Janete , Haddad Samira M. , Candreucci Carla B. , Guida José P. , Correa Junior Mario D. , Dias Marcos Ab , Oliveira Leandro G. , Melo Junior Elias F. , Da Luz Marília Gq , Costa Maria Laura ,   REBRACO Study Group
Published: November 2023

AbstractObjectivesTo compare maternal and perinatal outcomes among women with obesity, overweight, and normal body mass index, associated with COVID‐19 infection during pregnancy and postpartum.MethodProspective Cohort Study, within the REBRACO (Brazilian Network of COVID‐19 in Pregnancy) multicenter initiative. Confirmed positive cases of SARS‐CoV‐2 were included, and women categorized into three groups according to their pre‐pregnancy BMI: obesity (BMI ≥ 30), overweight (BMI <30 but >25), and normal BMI. Sociodemographic, clinical, and obstetric characteristics and different maternal and perinatal outcomes were compared, and a multiple regression analysis was performed to investigate factors independently associated with adverse maternal and perinatal outcomes.ResultsTwo hundred eighty‐nine women positive for SARS‐CoV‐2 infection were considered, and 202 had available data on maternal BMI for the current analysis. Overall, 72 (35.6%)obese, 68 (33.6%) overweight, and 60 (29.7%) normal BMI. Obesity was associated with increased adverse clinical outcomes including sepsis (P =  0.02), acute respiratory distress syndrome (P = 0.002), and the need for mechanical ventilation (P = 0.044). Considering perinatal outcomes, a multiple regression model confirmed obesity as an independent factor associated with adverse results (adjusted odds ratio 3.73, 95% CI 1.54–9.08).ConclusionObesity and overweight were associated with worse clinical outcomes, severe/critical COVID‐19, and adverse perinatal outcomes.
The impact on pregnancy outcomes of late‐onset gestational diabetes mellitus diagnosed during the third trimester: A systematic review and meta‐analysis
Authors: Sgayer Inshirah , Odeh Marwan , Wolf Maya Frank , Kaiyal Raneen Sawaid , Aiob Ala , Lowenstein Lior , Gratacos Eduard 
Published: November 2023

AbstractBackgroundEvidence is inconsistent regarding the impact of late gestational diabetes mellitus (GDM) on perinatal outcomes.ObjectivesTo evaluate associations of GDM diagnosed in the third trimester (late GDM) with adverse obstetric and neonatal outcomes.Search StrategyWe searched Embase, Medline, and Web of Science from January 1, 1990 to June 16, 2022, for observational studies.Selection CriteriaLate GDM was defined as a de novo diagnosis, i.e. after a negative screening for diabetes in the second trimester, and at later than 28 weeks of pregnancy.Data Collection and AnalysisEach abstract and full‐text article was independently reviewed by the same two authors. Quality was assessed with the use of the Newcastle‐Ottawa Scale. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effects model.Main ResultsTwelve studies were identified as meeting the inclusion criteria, including 3103 patients (571 with late GDM and 3103 controls). Incidences of shoulder dystocia (OR 1.57, 95% CI 1.02–2.42, P = 0.040), 5‐minute Apgar score <7 (OR 1.80, 95% CI 1.14–2.86, P = 0.024), cesarean delivery (OR 1.98, 95% CI 1.51–2.60, P < 0.001), and emergent cesarean delivery (OR 1.57, 95% CI 1.02–2.40, P = 0.040) were significantly higher among women with late GDM than among the controls. The groups showed similarity in the rates of fetal macrosomia, large‐for‐gestational‐age fetuses, neonatal hypoglycemia, and hypertensive disorders of pregnancy.ConclusionsThis meta‐analysis showed associations of late GDM with increased adverse perinatal outcomes. Prospective studies should evaluate the impact on perinatal outcomes of repeated third‐trimester screening for late GDM.
Re‐salvage focal low‐dose rate brachytherapy for local recurrence of prostate cancer after salvage focal low‐dose rate brachytherapy
Authors: Nakamoto Takahiro , Yoshida Takashi , Shiga Toshiko , Taguchi Makoto , Mishima Takao , Kawakita Shigenari , Murota Takashi , Kinoshita Hidefumi 
Published: November 2023

IntroductionSalvage brachytherapy represents an effective treatment for local recurrence of prostate cancer after prior external beam radiotherapy. However, the optimal therapeutic strategies for local recurrence after salvage brachytherapy have not yet been determined.Case presentationWe describe the case of a 77‐year‐old man who underwent re‐salvage focal low‐dose rate brachytherapy for local recurrence after carbon ion radiotherapy and salvage focal low‐dose rate brachytherapy. We performed re‐salvage focal low‐dose rate brachytherapy for the recurrence with a different type of seed, which resulted in a significant reduction in the prostate‐specific antigen level. During the 35‐month follow‐up after re‐salvage focal low‐dose rate brachytherapy, no recurrence of prostate cancer and no severe radiation‐related toxicities were observed.ConclusionOur patient was successfully treated with re‐salvage focal low‐dose rate brachytherapy for local recurrence after salvage focal low‐dose rate brachytherapy. This treatment strategy might be effective for such patients and is not associated with sexual dysfunction or severe adverse events.
Pilot study testing the effects of a multicomponent intervention for increasing moderate‐intensity physical exercise
Authors: Fournier Bryce A. , Andrade Leonardo F. 
Published: November 2023

AbstractPhysical inactivity has been associated with several health problems, including diabetes, obesity, and heart disease. Although many of these health problems are preventable through regular exercise, a small percentage of the adult population engages in the recommended levels. Reinforcement‐based interventions have been implemented successfully to promote physical activity, but studies targeting moderate or vigorous physical exercise using behavior‐analytic interventions are scarce. The purpose of the current study was to investigate the feasibility of a multicomponent intervention that provided monetary incentives for increasing running, jogging, or brisk walking distance for five adults. The intervention lasted 6 weeks and comprised weekly goal setting, feedback, public posting, and group contingencies. The results of the study suggest that the intervention may be feasible and effective at increasing moderate physical activity to levels recommended by the federal guidelines, but further research is warranted.
Ab initio molecular dynamics study of intersystem crossing dynamics for MH2 (M = Si, Ge, Sn, Pb) on spin‐pure and spin‐mixed potential energy surfaces
Authors: Wada Satoi , Tsutsumi Takuro , Saita Kenichiro , Taketsugu Tetsuya 
Published: November 2023

AbstractRecently, surface‐hopping ab initio molecular dynamics (SH‐AIMD) simulations have come to be used to discuss the mechanisms and dynamics of excited‐state chemical reactions, including internal conversion and intersystem crossing. In dynamics simulations involving intersystem crossing, there are two potential energy surfaces (PESs) governing the motion of nuclei: PES in a spin‐pure state and PES in a spin‐mixed state. The former gives wrong results for molecular systems with large spin‐orbit coupling (SOC), while the latter requires a potential gradient that includes a change in SOC at each point, making the computational cost very high. In this study, we systematically investigate the extent to which the magnitude of SOC affects the results of the spin‐pure state‐based dynamics simulations for the hydride MH2 (M = Si, Ge, Sn, Pb) by performing SH‐AIMD simulations based on spin‐pure and spin‐mixed states. It is clearly shown that spin‐mixed state PESs are indispensable for the dynamics simulation of intersystem crossing in systems containing elements Sn and Pb from the fifth period onward. Furthermore, in addition to the widely used Tully's fewest switches (TFS) algorithm, the Zhu‐Nakamura (ZN) global switching algorithm, which is computationally less expensive, is applied to SH for comparison. The results from TFS‐ and ZN‐SH‐AIMD methods are in qualitative agreement, suggesting that the less expensive ZN‐SH‐AIMD can be successfully utilized to investigate the dynamics of photochemical reactions based on quantum chemical calculations.
Iron oxide nanoparticles as iron micronutrient fertilizer—Opportunities and limitations
Authors: Shirsat Shraddha , K Suthindhiran 
Published: November 2023

AbstractIron (Fe) is necessary for plant growth and development. Iron deficiency disrupts major metabolic and cellular activities such as respiration, DNA synthesis, and chlorophyll synthesis. Iron also activates various metabolic pathways and is vital to numerous enzymes. Iron is widely distributed in soil, but plants do not readily absorb it. In addition to neutral pH, Fe also forms insoluble Fe complexes under alkaline conditions. The fundamental cause of Fe chlorosis is an imbalance between the solubility of Fe in soil and the demand for Fe by plants. Various Fe fertilizers, including organic, chelated, and inorganic, are administered to the soil and leaves to treat Fe deficiency and chlorosis. Currently, used Fe fertilizers are expensive, easily adsorb on soil particles, and cause Fe to leach out of the soil with water, thereby diminishing their efficiency. They also need to be applied repeatedly, resulting in an excessive Fe fertilizer concentration in the soil that can cause harm to the plants. The usage of Fe nanofertilizers in agricultural production has expanded to address the disadvantages of existing Fe fertilizers. The advantages of nanosized Fe fertilizers include their physical and chemical characteristics, such as the high surface area to volume ratio that aids in easy absorption by plants’ roots and leaves. Controlled‐release iron oxide nanofertilizers supply the regulated release of nutrients in a way that is coordinated with the nutritional needs of the crops. This improves the accumulation of nutrients in the plant, filling in the gap of nutrient deficiency and lowering environmental risks due to leaching. The possibility of iron oxide nanoparticles as Fe micronutrient fertilizers, their uptake and mechanism of action, advantages, and limitations are critically highlighted in this review article.
Associations between femoral 3D curvature and sagittal imbalance of spine
Authors: Lo Chien‐Hsiung , Dean Fang Yu‐Hua , Wang Jing‐Yao , Yu Tzu‐Ping , Chuang Hao‐Chun , Liu Yuan‐Fu , Chang Chao‐Jui , Lin Cheng‐Li 
Published: November 2023

AbstractBackgroundThe sagittal imbalance (SI) of spine triggers compensatory mechanisms (CMs) of lower extremity (LE) to restore trunk balance. These CMs can cause long‐period stress on the femur and may possibly alter the femoral morphology. This cross‐sectional observational study aimed to answer the following questions: (a) Do SI subjects exhibit greater femoral bowing compared to subjects with sagittal balance? (b) Are there associations between femoral bowing and CMs of LE in SI subjects?MethodsSubjects who underwent biplanar full body radiographs with the EOS imaging system between January 2016 and September 2021 were recruited. Sagittal parameters included T1‐pelvic angle (TPA), pelvic incidence (PI), pelvic tilt (PT), sacral slope, lumbar lordosis (LL), PI‐LL, and PT/PI ratio. LE parameters were femoral obliquity angle (FOA), knee flexion angle (KA), and ankle dorsiflexion angle. Femoral bowing was quantified as 3D radius of femoral curvature (RFC). Associations between 3D RFC and the radiographic parameters were analyzed.ResultsA total of 105 subjects were included, classified into balance group (TPA < 14°, n = 40), SI group (TPA ≥ 14° and KA <5°, n = 30), and SI with knee flexion group (TPA ≥ 14° and KA ≥ 5°, n = 35). 3D RFC was significantly lower in SI with knee flexion group compared to the other two groups (both p < 0.001). Stepwise linear regression showed that age, SI and knee flexion, femoral length (FL), FOA, and KA were independent predictors for 3D RFC.ConclusionGreater femoral bowing is observed in subjects with SI and knee flexion compared to the balanced population. CM parameters, including KA and FOA, are associated with 3D RFC. Further longitudinal study is needed to investigate the cause‐and‐effect relationship between SI, CMs of LE, and femoral bowing.
Impact of Universal Vasa Previa Screening With Color Doppler During the OB Ultrasound Anatomy Scan
Authors: Bihun Rebekah , Trinidad Marie Charisse , Packard Ann T. 
Published: November 2023

ObjectivesOur institution introduced universal vasa previa (VP) screening utilizing transabdominal ultrasound with color Doppler for all pregnancies at the second trimester anatomy scan. Our study sought to describe the clinical impact of this intervention.MethodsRadiology records from the 12 months pre‐ and post‐intervention were queried for “vasa previa.” Records included for analysis were those with a first‐time diagnosis or discussion of VP at the anatomy scan. Cases were categorized by outcome: (Group 1) True VP, with subgroups A, unresolved by time of delivery and B, resolved by delivery; (Group 2) False positives; (Group 3) Possible VP without definitive diagnosis; and (Group 4) VP ruled out, for example, “no features of VP.” Group size was expressed as a percentage of total anatomy scans during pre‐ or post‐intervention periods respectively. Absolute and relative percent change were calculated for each group.ResultsIn the pre‐intervention period, 1 case (0.36% of total scans) was categorized in Group 1A, 1 case (0.36%) in Group 3, and 7 cases (2.53%) in Group 4. In the post‐intervention period, 2 cases (0.30%) were in Group 1A, 4 cases (0.61%) in Group 1B, 2 cases (0.30%) in Group 2, 1 case (0.15%) in Group 3, and 7 cases (1.06%) in Group 4. There was a +153% relative change in true positives, from 0.36 to 0.91%.ConclusionsUniversal color Doppler screening may have increased detection (sensitivity) while simultaneously increasing false positives (decreased specificity). While decreasing sensitivity is not ideal, this is acceptable given the potential catastrophic outcome of a missed VP.
Manufacturer's online recycling channel intrusion strategies considering digital technology enabling and government subsidies
Authors: Yao Fengmin , Wang Yufei , Yan Yingluo , Liu Shan 
Published: November 2023

AbstractWe constructed closed‐loop supply chain decision‐making models for digital technology empowerment considering government subsidies and analyzed the interaction between subsidy strategies and digital technology empowerment decisions. We found that when manufacturer does not (does) implement online recycling channel intrusion, government subsidies have (have not) a transmission effect. However, when the government subsidizes manufacturer (recycling platform), channel intrusion will increase (decrease) the digital technology empowerment level of recycling platform. Meanwhile, excessive subsidies for recycling platform are not conducive to remanufacturing. In addition, when consumers' digital sensitivity is weak, government subsidies to manufacturer is more conducive to increasing social welfare.
Modelling and inferring fracture curvature from borehole GPR data: A case study from the Bedretto Laboratory, Switzerland
Authors: Escallon Daniel , Shakas Alexis , Maurer Hansruedi 
Published: November 2023

AbstractFracture curvature has been observed from the millimetre to the kilometre scales. Nevertheless, characterizing curvature remains challenging due to data sparsity and geometric ambiguities. As a result, most numerical models often assume planar fractures to ease computations. To address this limitation, we present a novel approach for inferring fracture geometry from travel‐time data of electromagnetic or seismic waves. Our model utilizes co‐kriging interpolation of control points in a three‐dimensional surface mesh to simulate fracture curvature effectively, resulting in an unstructured triangular grid. We then refine the fracture surface into a structured grid with equidistant elements so that both small‐scale heterogeneities and large‐scale curvature can be modelled. To constrain the fracture geometry, we perform a deterministic travel‐time inversion to optimally place these control points. We validate our methodology with synthetic data and address its limitations. Finally, we infer the geometry of a large (more than 200 m) fracture observed in single‐hole ground‐penetrating radar field data. The fracture surface closely agrees with borehole televiewer observations and is also constrained far from the boreholes. Our modelling approach can be trivially adapted to multi‐offset ground‐penetrating radar or active seismic data.
Insight into acrolein activation by P/B intramolecular frustrated Lewis pairs
Authors: Sinha Swapan , Das Subhra , Giri Santanab 
Published: November 2023

AbstractThe study investigates the reactivity of a cyclic five‐membered intramolecular P/B frustrated Lewis pair towards acrolein through a cycloaddition reaction. Intrinsic reaction coordinate (IRC) calculations suggest the single‐step mechanism. It has been observed that the cycloaddition reaction occurs through a concerted mechanism in both the presence and absence of the catalyst. Analysis of reaction force and reaction electronic flux provides valuable information about the total work required and electronic activity along the IRC. Additionally, natural bonding orbital (NBO) analyses enrich the understanding of the mechanism in terms of the electron transfer process during the chemical reaction.
Investigation of a monophasic Salmonella Typhimurium outbreak linked to chocolate products as part of wider international outbreak: A matched case–control study, Ireland, 2022
Authors: Nielsen Charlotte Salgaard , Garvey Patricia , Cormican Martin , DeLappe Niall , Lenahan Mary , Moore Orla , Casey Kay , Cotter Suzanne , Gee Sarah , Aniugbo Benjamin , Meagher Gerard , Brabazon Elaine , Quintyne Keith Ian , Breslin Anthony , McBride RoseMary , Burke Eimear , White Margaret , Casey Marie , Evans Leah , Conlon Catherine , Dillon Annette , Kiernan Regina , Kilmartin Donna , Lawlor Cale , McDermott Ruth , McKeown Paul ,   Outbreak Control Team
Published: November 2023

AbstractBackgroundIn March 2022, an outbreak investigation was initiated in Ireland after identifying a cluster of monophasic Salmonella Typhimurium cases, affecting primarily small children. Microbiological investigations revealed that the cluster was part of a wider international outbreak.MethodsA total of 18 Irish outbreak cases were identified. We undertook a matched case–control study using the case–case method to determine if exposure to the implicated products was associated with illness.ResultsIn univariable analysis, the highest odds of disease due to monophasic S. Typhimurium versus other gastrointestinal disease were obtained for a chocolate Product A of Brand A [matched odds ratio (mOR) = 7.77, 95% confidence intervals (CI): 0.89–67.20]. When grouping the implicated products in a composite variable, the odds of disease due to monophasic S. Typhimurium versus other gastrointestinal disease were 10.5 times higher with a consumption of at least one of the implicated products [mOR = 10.50, 95% CI: 1.24–88.60, p = 0.031].ConclusionThis analytical study supported the internationally generated hypothesis which led to the implementation of control measures. Owing to the high levels of chocolate purchasing with Easter approaching, early outbreak identification and involvement in the internationally coordinated investigation was essential to an efficient response and to minimise the risk of further harm to a particularly vulnerable population group.
Theoretical perspective on synthetic man‐made life: Learning from the origin of life
Authors: Peng Lu , Zhang Zecheng , Wang Xianyi , Qiu Weiyi , Zhou Liqian , Xiao Hui , Liu Chunxiuzi , Tang Shaohua , Qin Zhiwei , Jiang Jiakun , Di Zengru , Liu Yu 
Published: November 2023

AbstractCreating a man‐made life in the laboratory is one of life science’s most intriguing yet challenging problems. Advances in synthetic biology and related theories, particularly those related to the origin of life, have laid the groundwork for further exploration and understanding in this field of artificial life or man‐made life. But there remains a wealth of quantitative mathematical models and tools that have yet to be applied to this area. In this paper, we review the two main approaches often employed in the field of man‐made life: the top‐down approach that reduces the complexity of extant and existing living systems and the bottom‐up approach that integrates well‐defined components, by introducing the theoretical basis, recent advances, and their limitations. We then argue for another possible approach, namely “bottom‐up from the origin of life”: Starting with the establishment of autocatalytic chemical reaction networks that employ physical boundaries as the initial compartments, then designing directed evolutionary systems, with the expectation that independent compartments will eventually emerge so that the system becomes free‐living. This approach is actually analogous to the process of how life originated. With this paper, we aim to stimulate the interest of synthetic biologists and experimentalists to consider a more theoretical perspective, and to promote the communication between the origin of life community and the synthetic man‐made life community.
Conductive proteins‐based extracellular electron transfer of electroactive microorganisms
Authors: Zhang Junqi , You Zixuan , Liu Dingyuan , Tang Rui , Zhao Chao , Cao Yingxiu , Li Feng , Song Hao 
Published: November 2023

AbstractElectroactive microorganisms (EAMs) could utilize extracellular electron transfer (EET) pathways to exchange electrons and energy with their external surroundings. Conductive cytochrome proteins and nanowires play crucial roles in controlling electron transfer rate from cytosol to extracellular electrode. Many previous studies elucidated how the c‐type cytochrome proteins and conductive nanowires are synthesized, assembled, and engineered to manipulate the EET rate, and quantified the kinetic processes of electron generation and EET. Here, we firstly overview the electron transfer pathways of EAMs and quantify the kinetic parameters that dictating intracellular electron production and EET. Secondly, we systematically review the structure, conductivity mechanisms, and engineering strategies to manipulate conductive cytochromes and nanowire in EAMs. Lastly, we outlook potential directions for future research in cytochromes and conductive nanowires for enhanced electron transfer. This article reviews the quantitative kinetics of intracellular electron production and EET, and the contribution of engineered c‐type cytochromes and conductive nanowire in enhancing the EET rate, which lay the foundation for enhancing electron transfer capacity of EAMs.