bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical versus angled immediately loaded implants for assisting maxillary overdentures with locator attachments: A preliminary results of one‐year randomized clinical trial
Authors: Aboelez Marwa Ahmed , Ibrahim Christine Raouf Micheal , Helmy Mohamad Hossam El‐Din , Elsyad Moustafa Abdou 
Published: November 2023

AbstractObjectivesThis study aimed to evaluate the clinical outcomes and patient satisfaction of 4‐implant‐assisted maxillary overdentures using two different designs.Materials and MethodsThirty edentulous participants received four implants in the maxillary ridge. The patients were randomly divided into two equal groups: (1) the control (CG, Vertical) group (n = 15); participants received four vertical implants with straight locator attachments to retain maxillary overdentures, and (2) the study (SG, Angled) group (n = 15); participants received four angled implants with angled locator attachments to retain maxillary overdentures. Peri‐implant tissue health [Plaque (PL) and gingival (GI) indices, pocket depth (PD), implant stability (ISQ) and crestal bone loss (CBL)] were evaluated after denture insertion (T0), 6 (T6), and 12 (T12) months after insertion. Patient satisfaction was evaluated using a visual analog scale (VAS) after 12 months.ResultsThe survival rates were 96.7% and 95% for the control and study groups respectively. PL, GI, and PD increased significantly in both groups with the passage of time. No significant difference in PL, GI, PD, and ISQ was noted between groups at all observation times. CG showed higher CBL than SG at T12. For the VAS results, there was no significant difference between groups. SG recorded significantly higher satisfaction regarding comfort with maxillary and mandibular dentures, retention of mandibular dentures, oral hygiene, the ability to chew hard food, and occlusion than CG.ConclusionWithin the limitations of this study, angled implants with angled locator attachments may be recommended to retain maxillary overdentures opposing intact dentition or fixed restoration as it was associated with improvements of several parameters of peri‐implant tissue health and patient satisfaction compared to vertical implants with straight locator attachments.
Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell‐derived secretome in preclinical models of morphine dependence
Authors: Quezada Mauricio , Ponce Carolina , Berríos‐Cárcamo Pablo , Santapau Daniela , Gallardo Javiera , De Gregorio Cristian , Quintanilla María Elena , Morales Paola , Ezquer Marcelo , Herrera‐Marschitz Mario , Israel Yedy , Andrés‐Herrera Paula , Hipólito Lucia , Ezquer Fernando 
Published: November 2023

AbstractBackgroundMorphine is an opiate commonly used in the treatment of moderate to severe pain. However, prolonged administration can lead to physical dependence and strong withdrawal symptoms upon cessation of morphine use. These symptoms can include anxiety, irritability, increased heart rate, and muscle cramps, which strongly promote morphine use relapse. The morphine‐induced increases in neuroinflammation, brain oxidative stress, and alteration of glutamate levels in the hippocampus and nucleus accumbens have been associated with morphine dependence and a higher severity of withdrawal symptoms. Due to its rich content in potent anti‐inflammatory and antioxidant factors, secretome derived from human mesenchymal stem cells (hMSCs) is proposed as a preclinical therapeutic tool for the treatment of this complex neurological condition associated with neuroinflammation and brain oxidative stress.MethodsTwo animal models of morphine dependence were used to evaluate the therapeutic efficacy of hMSC‐derived secretome in reducing morphine withdrawal signs. In the first model, rats were implanted subcutaneously with mini‐pumps which released morphine at a concentration of 10 mg/kg/day for seven days. Three days after pump implantation, animals were treated with a simultaneous intravenous and intranasal administration of hMSC‐derived secretome or vehicle, and withdrawal signs were precipitated on day seven by i.p. naloxone administration. In this model, brain alterations associated with withdrawal were also analyzed before withdrawal precipitation. In the second animal model, rats voluntarily consuming morphine for three weeks were intravenously and intranasally treated with hMSC‐derived secretome or vehicle, and withdrawal signs were induced by morphine deprivation.ResultsIn both animal models secretome administration induced a significant reduction of withdrawal signs, as shown by a reduction in a combined withdrawal score. Secretome administration also promoted a reduction in morphine‐induced neuroinflammation in the hippocampus and nucleus accumbens, while no changes were observed in extracellular glutamate levels in the nucleus accumbens.ConclusionData presented from two animal models of morphine dependence suggest that administration of secretome derived from hMSCs reduces the development of opioid withdrawal signs, which correlates with a reduction in neuroinflammation in the hippocampus and nucleus accumbens.
Alteration of body representation in typical and atypical motor development
Authors: Gauduel Thomas , Blondet Camille , Gonzalez‐Monge Sibylle , Bonaiuto James , Gomez Alice 
Published: November 2023

AbstractDevelopmental coordination disorder (DCD) impacts the quality of life and ability to perform coordinated actions in 5% of school‐aged children. The quality of body representations of individuals with DCD has been questioned, but never assessed. We hypothesize that children with DCD have imprecise body representations in the sensory and motor domains. Twenty neurotypical children, seventeen children with DCD (8–12 years old) and twenty neurotypical adults (25–45 years old) performed both sensory and motor body representation tasks: a limb identification and a limb movement task. We observed lower accuracy in the sensory task but not in the motor task. In both tasks, we observe a larger amplitude of errors, or synkinesis, in children with DCD than in neurotypical children. In neurotypical children, accuracy was lower than in neurotypical adults in the motor and sensory task, and the amplitude of sensory errors and synkinesis was higher than in neurotypical adults. Using a linear regression model, we showed that sensory accuracy is a good predictor of synkinesis production, and that synkinesis production is a good predictor of sensory accuracy, as can be expected by the perception‐action loop. Results support the hypothesis of an imprecision of body representation in DCD. We suggest that this imprecision arises from noise in the body representation used at the level of internal models of action. Future studies may assess whether slower plasticity of body representations, initial imprecision, or both may account for this observation. At the clinical level, prevention strategies targeting body representation in early childhood are strategically important to limit such impairments.Research HighlightsBody representation is impaired in children with DCD and has a significant cost in terms of the accuracy of sensory identification of body parts and associated movements.Inaccuracies in the body representation measured in perception and in action (error amplitude and synkinesis) are related in both NT children and adults.In typical development, we provide evidence of a strong link between body schema and body image.
Real‐world outcomes with immunosuppressive therapy for aplastic anemia in patients treated at the University of Michigan
Authors: Foucar Charles E. , Foley Daniel H. , Aldous Jessica , Burke Patrick W. , Pettit Kristen R. , Benitez Lydia L. , Perissinotti Anthony J. , Marini Bernard L. , Boonstra Philip , Bixby Dale L. 
Published: November 2023

AbstractAplastic anemia (AA) is a rare bone marrow failure disorder that is treated with either allogeneic stem cell transplant or immunosuppressive therapy (IST) consisting of antithymocyte globulin (ATG), cyclosporine (CSA), and eltrombopag. While outcomes are favorable in younger patients, older patients (>60) have significantly worse long‐term survival. The dose of ATG is often reduced in older patients and those with multiple comorbidities given concerns for tolerability. The efficacy and safety of dose‐attenuated IST in this population is largely undescribed. We performed a retrospective review of patients with AA treated with IST. Our analysis was confounded by changes in practice patterns and the introduction of eltrombopag. We identified 53 patients >60 years old, of which, 20 received dose‐attenuated IST, with no statistically significant difference in overall survival between full and attenuated dose cohorts. Overall response rates in both cohorts were similar at 6 months at 71% and 68%. There were more documented infectious complications in the full dose cohort (13 vs. 3). This supports the consideration of dose‐attenuated IST in older patients with concerns about tolerance of IST. Lastly, our data confirmed favorable outcomes of younger patients receiving IST, especially in combination with eltrombopag.
From a cause of rapid fig tree dieback to a new threat to mango production: the invasive bark beetle Cryphalus dilutus Eichhoff (Coleoptera: Curculionidae, Scolytinae) and its associated fungi found on mango trees in Europe
Authors: Gugliuzzo Antonio , Gusella Giorgio , Leonardi Giuseppa Rosaria , Costanzo Mariangela Benedetta , Ricupero Michele , Rassati Davide , Biondi Antonio , Polizzi Giancarlo 
Published: November 2023

AbstractBark and ambrosia beetles (Coleoptera: Curculionidae) are receiving increasing scientific interest because of the economic losses that they can cause in invaded areas. Nonetheless, there are a number of emerging pest species, belonging to different tribes, for which invasions have likely been overlooked in the past due to their inconspicuousness, taxonomic confusion and/or misidentification. In the summer of 2022, severe infestations by a bark beetle species belonging to the tribe Cryphalini were observed on mango (Mangifera indica L.) in Eastern Sicily (Italy). No information about bark beetle attacks on mango trees in Europe was available previously. However, the occurrence of a cryphaline bark beetle species causing rapid common fig tree (Ficus carica L.) dieback was reported for the same investigated area in 2014 and 2015. We aimed to identify the bark beetle species attacking mango and common figs, and to describe the fungal pathogens vectored by this beetle species. Our results revealed that the bark beetle species attacking mango and fig trees in the studied area is Cryphalus dilutus Eichhoff and that different fungal pathogens, i.e., species of Botryosphaeriaceae, Ceratocystis ficicola and Neocosmospora spp., are vectored by this beetle species.
Evaluation of robocasting process in the layering of dental feldspathic porcelain in metal‐ceramic restorations
Authors: Dimitriadis Konstantinos , Roussi Eleni , Baciu Diana , Garmpi Eleni , Tsetsekou Athena , Andreouli Constantina‐Dia 
Published: November 2023

AbstractThe objective of the present in vitro study was to evaluate the robocasting process for the fabrication of metal‐ceramic dental restorations, according to ISO 9693. In this work, the rheological properties of dental porcelain pastes doped with organic additives and the parameters of robocasting process were determined, and the microstructural and physical‐mechanical characterization of the sintered material were performed. Subsequently, the suitability of the robocasting process for the production of metal‐ceramic dental restorations was evaluated. Results revealed that the dental feldspathic porcelain specimens, prepared by robocasting process, exhibited a homogeneous and dense microstructure with little or no microporosity, and the measured mechanical properties point towards good performance in oral cavity. The metal‐ceramic bonds produced by the robocasting process have markedly higher strength values than the minimum value of 25 MPa, required by ISO 9693, with a cohesive failure mode.
Bone marrow adipocyte: Origin, biology and relationship with hematological malignancy
Authors: Wang Yan , Yang Chunxia , Wan Junzhao , Liu Ping , Yu Hantao , Yang Xiaoyan , Ma Dan 
Published: November 2023

AbstractBone marrow adipose tissue (BMAT) has been histologically recognized for decades. In this study, we performed a bibliometric analysis to quantitatively analyze the clusters of keywords of BMAT and hematopoiesis to better understand BMAT and hematopoiesis. Starting with conclusive keywords, our results demonstrated that BMAds is distinct from extramedullary adipose tissues and maintains a routine but dynamic accumulation throughout an individual's life. Various pathophysiological factors take part in dysregulation of the adipose‐osteogenic balance throughout life. Bone marrow adipocytes (BMAds) are also contradictorily involved in normal hematopoiesis, and positively participate in the occurrence and progression of hematologic malignancies, exerting a chemoprotective role in tumor treatment. Mechanically, metabolic reprogramming and abnormal secretory profile of BMAds and tumor cells play a critical role in the chemotherapy resistance. Overall, we hope that this work will provide new ideas for relevant future research on BMAds.
Adrenaline autoinjectors for Australian out‐of‐hospital anaphylaxis: where to from here?
Authors: Wiseman Thomas J. , Kovoor Joshua G. , Jiang Melinda , Stretton Brandon , Gupta Aashray K. , Bacchi Stephen , Kette Frank E. 
Published: November 2023

AbstractIntramuscular adrenaline autoinjectors are accepted as first‐line treatment for out‐of‐hospital anaphylaxis but face ongoing issues of patient nonadherence related to drug expiry, availability, correct administration, and public recognition of the disease. Adrenaline is associated with possible harms in patients with defined comorbidities but is still considered preferable. Further research and policy is required to facilitate the effective treatment of anaphylaxis.
A minority of women of childbearing potential are tested for pregnancy before chemoimmunotherapy: an Australian cancer centre experience
Authors: Chadwick Verity , Kim Michaela , Mills Georgia , Tang Catherine , Anazodo Antoinette , Dear Rachel , Rodgers Rachael , Lavee Orly , Milliken Sam , McCaughan Georgia , Hamad Nada 
Published: November 2023

AbstractBackgroundChemotherapy is potentially harmful to a developing foetus, and there are limited data on the foetal impact of chemoimmunotherapy (CIT). Therefore, determining pregnancy status prior to initiation of CIT should be standard of care.AimsTo determine how many women of childbearing age are tested for pregnancy prior to immunochemotherapy administration.MethodsA retrospective chart review at a large Australian metropolitan cancer referral centre, including 304 women aged 18–51 years with a diagnosis of cancer receiving outpatient‐based CIT between 1 May 2015 and 12 June 2020. We assessed the uptake of pregnancy screening and contraception counselling prior to and during first‐line CIT.ResultsOnly 17.3% of CIT cycles (n = 416) screened patients for pregnancy no more than 90 days prior to administration, and the median time between pregnancy screening and treatment was approximately 3 weeks. One patient with early breast cancer had a spontaneous miscarriage estimated at 3–4 weeks' gestation, and neither the patient nor the treating oncologist was aware of this event. This was also the only patient who had a pregnancy test beyond the first cycle of CIT during their treatment.ConclusionsOur results highlight a concerningly low rate of pregnancy screening in women of childbearing age receiving CIT. The implication of missing a positive pregnancy test in this group of women could result in foetal complications, accidental miscarriage, potential bleeding risks and avoidable psychosocial stress. This highlights the urgent need for guidelines to mandate pregnancy testing in women of childbearing age receiving CIT and evidence‐based implementation tools.
Strengthening influenza surveillance capacity in the Eastern Mediterranean Region: Nearly two decades of direct support from the United States Centers for Disease Control and Prevention
Authors: Zureick Kinda , McCarron Margaret , Dawson Patrick , Davis Jamie K. , Barnes John , Wentworth David , Azziz‐Baumgartner Eduardo 
Published: November 2023

AbstractSince 2004, the US Centers for Disease Control and Prevention (CDC) Influenza Division (ID) has supported seven countries in the Eastern Mediterranean region and the World Health Organization Regional Office for the Eastern Mediterranean to establish and strengthen influenza surveillance. The substantial growth of influenza surveillance capacities in the region demonstrates a commitment by governments to strengthen national programs and contribute to global surveillance. The full value of surveillance data is in its use to guide local public health decisions. CDC ID remains committed to supporting the region and supporting partners to translate surveillance data into policies and programs effectively.
The effects of preosteoblast‐derived exosomes on macrophages and bone in mice
Authors: Hakki Sema S. , Batoon Lena , Koh Amy J. , Kannan Rahasudha , Mendoza‐Reinoso Veronica , Rubin John , Mccauley Laurie K. , Roca Hernan 
Published: November 2023

AbstractThe effect of preosteoblast‐derived exosomes on bone marrow macrophages (BMMΦ) and calvarial osteoblasts (cOB) was evaluated in vitro, and bone formation studies were performed in vivo in mice. Preosteoblastic MC3T3‐E1 clone 4 (MC4) cell‐derived exosomes (MC4exo) were characterized with particle tracking, transmission electron microscopy and western blot analysis to validate size, number, shape and phenotypic exosome markers. Exosomes pre‐labelled with PKH67 were incubated with BMMΦ and phagocytosis of exosomes was confirmed. To examine the effect of MC4exo on macrophage polarization, BMMΦ were treated with MC4exo and the expression of pro‐ and anti‐inflammatory cytokines was determined by qPCR. MC4exo treatment upregulated mRNA expression of Cd86, Il1β, Ccl2, Rankl and Nos, and downregulated Cd206, Il10 and Tnfα, suggesting a shift towards pro‐inflammatory ‘M1‐like’ macrophage polarization. Combination of RANKL and MC4exo increased osteoclast differentiation of BMMΦ in comparison to RANKL alone as analysed by TRAP staining. MC4exo treatment showed no significant effect on calvarial osteoblast mineralization. For in vivo studies, intratibial inoculation of MC4exo (2 × 109 particles in PBS, n = 12) and vehicle control (PBS only, n = 12) was performed in C57Bl/6 mice (8 weeks, male). Micro‐CT analyses of the trabecular and cortical bone compartments were assessed at 4 weeks post‐injection. Tibial sections were stained for TRAP activity to determine osteoclast presence and immunofluorescence staining was performed to detect osteocalcin (Ocn), osterix (Osx) and F4/80 expression. Intratibial inoculation of MC4exo increased the diaphyseal bone mineral density and trabecular bone volume fraction due to increased trabecular number. This increase in bone was accompanied by a reduction in bone marrow macrophages and osteoclasts at the experimental endpoint. Together, these findings suggest that preosteoblast‐derived exosomes enhanced bone formation by influencing macrophage responses.
Product variety and design in the age of peer‐to‐peer sharing
Authors: Zennyo Yusuke 
Published: November 2023

AbstractThe rise of peer‐to‐peer (P2P) sharing, exemplified recently by increased car‐sharing and clothing‐sharing, has altered our consumption style. One can consume goods without owning them. In fact, the ownership of goods can be monetized through P2P rental markets. These changes are regarded as influencing various strategies of manufacturers of goods being shared. Specifically, this paper examines aspects of product variety and design. A stylized model is examined in which a manufacturing firm makes a product variety decision of whether to launch a niche product line in addition to an existing mass product line. Consumers are of two types, including average consumers, who value the niche product less than the mass product, and snob consumers, who evaluate the niche product highly. Results demonstrate that the existence of P2P sharing makes consumers' ownership decisions immaterial, which alleviates difficulties of cannibalization between mass and niche product lines and which therefore encourages firms to widen their product variety. Moreover, to address issues of product design, the model is extended to allow the firm to choose the degree of niche‐serving of the second product line endogenously. Results show that P2P sharing deters a firm from designing a niche for the second product line.
High‐density lipoprotein remodeling affects the osmotic properties of plasma in goldfish under critical salinity
Authors: Andreeva Alla M. , Lamash Nina , Martemyanov V. I. , Vasiliev A. S. , Toropygin I. Yu. , Garina D. V. 
Published: November 2023

AbstractTo investigate the stress response and physiological adaptations of goldfish (Carassius auratus) to critical salinity (CS) waters, we analyzed high‐density lipoprotein (HDL) stoichiometry, stress markers (cortisol, glucose), and plasma osmotic properties (Na+, osmolality, water content) using ichthyology, biochemistry, and proteomics approaches. After 21 days of exposure to CS, plasma concentrations of cortisol, glucose, and Na+ increased, indicating stress. Total plasma osmolality (Osmtotal) and osmolality generated by inorganic (Osminorg) and organic osmolytes (Osmorg) also increased, the latter by ~2%. We associated the increase of Osmorg with (1) increased metabolite concentration (glucose), (2) dissociation of HDL particles resulting in increased HDL number per unit plasma volume (~1.5–2‐fold) and (3) increased HDL osmotic activity. HDL remodeling may be the reason for the redistribution of bound and free water in plasma, which may contribute to water retention in plasma and, at the same time, to hemodynamic disturbances under CS conditions. The study's findings suggest that HDL remodeling is an important mechanism for maintaining osmotic homeostasis in fish, which is consistent with current capillary exchange models in vertebrates.