bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the CTS5 a helpful decision-making tool in the extended adjuvant therapy setting?
Authors: Wimmer Kerstin , Hlauschek Dominik , Balic Marija , Pfeiler Georg , Greil Richard , Singer Christian F. , Halper Stefan , Steger Günther , Suppan Christoph , Gampenrieder Simon P. , Helfgott Ruth , Egle Daniel , Filipits Martin , Jakesz Raimund , Sölkner Lidija , Fesl Christian , Gnant Michael , Fitzal Florian 
Published: January 2024

Abstract
Purpose
The Clinical Treatment Score post-5 years (CTS5) is an easy-to-use tool estimating the late distant recurrence (LDR) risk in patients with hormone receptor-positive breast cancer after 5 years of endocrine therapy (ET). Apart from evaluating the prognostic value and calibration accuracy of CTS5, the aim of this study is to clarify if this score is able to identify patients at higher risk for LDR who will benefit from extended ET.

Methods
Prognostic power, calibration, and predictive value of the CTS5 was tested in patients of the prospective ABCSG-06 and -06a trials (n = 1254 and 860 patients, respectively). Time to LDR was analyzed with Cox regression models.

Results
Higher rates of LDR in the years five to ten were observed in high- and intermediate-risk patients compared to low-risk patients (HR 4.02, 95%CI 2.26–7.15, p < 0.001 and HR 1.93, 95%CI 1.05–3.56, p = 0.035). An increasing continuous CTS5 was associated with increasing LDR risk (HR 2.23, 95% CI 1.74–2.85, p < 0.001). Miscalibration of CTS5 in high-risk patients could be observed. Although not reaching significance, high-risk patients benefitted the most from prolonged ET with an absolute reduction of the estimated 5-year LDR of − 6.1% (95%CI − 14.4 to 2.3).

Conclusion
The CTS5 is a reliable prognostic tool that is well calibrated in the lower and intermediate risk groups with a substantial difference of expected versus observed LDR rates in high-risk patients. While a numerical trend in favoring prolonged ET for patients with a higher CTS5 was found, a significantly predictive value for the score could not be confirmed.

Clinical trial registration
ABCSG-06 trial (NCT00309491), ABCSG-06A7 1033AU/0001 (NCT00300508).
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
Authors: Li Chenxi , Chen Siqi , Fang Xiaona , Du Yaqing , Guan Xin-Yuan , Lin Runhua , Xu Liang , Lan Ping , Yan Qian 
Published: January 2024

Abstract
Background
Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are main factors of poor prognosis in CRC patients. Lysyl oxidase like 1 (LOXL1), part of the lysyl oxidase (LOX) family, plays a yet unclear role in CRC. This study aimed to identify effective biomarkers predictive of prognosis and efficacy of immunotherapy in CRC patients, and to elucidate the prognostic value, clinical relevance, functional and molecular features, and immunotherapy predictive role of LOXL1 in CRC and pan-cancer.

Methods
Weighted gene co-expression network analysis (WGCNA) was employed to explore gene modules related to tumor metastasis and CD8 + T cell infiltration. LOXL1 emerged as a hub gene through differential gene expression and survival analysis. The molecular signatures, functional roles, and immunological characteristics affected by LOXL1 were analyzed in multiple CRC cohorts, cell lines and clinical specimens. Additionally, LOXL1's potential as an immunotherapy response indicator was assessed, along with its role in pan-cancer.

Results
Turquoise module in WGCNA analysis was identified as the hub module associated with lymph node metastasis and CD8 + T cell infiltration. Aberrant elevated LOXL1 expression was observed in CRC and correlated with poorer differentiation status and prognosis. Molecular and immunological characterization found that LOXL1 might mediate epithelial-mesenchymal transition (EMT) process and immunosuppressive phenotypes of CRC. Functional study found that LOXL1 enhanced tumor cell proliferation, migration and invasion. Moreover, high LOXL1 levels corresponded to reduced CD8 + T cell infiltration and predicted poor clinical outcomes of immunotherapy. Similar trends were also observed at the pan-cancer level.

Conclusions
Our findings underscore the critical role of LOXL1 in modulating both malignancy and immunosuppression in CRC. This positions LOXL1 as a promising biomarker for predicting prognosis and the response to immunotherapy in CRC patients.

Graphical Abstract
When Moral Talk Becomes Profitable
Authors: Juarez-Garcia Mario I. 
Published: January 2024

AbstractShould businesses engage in moral talk when it becomes profitable? Due to their particular position of visibility, it is reasonable to acknowledge that businesses have specific moral duties. Some might argue that companies ought to help abandon morally repugnant norms by providing examples of alternative behaviors through advertisements. However, the moral talk of businesses might unexpectedly reinforce repugnant norms and increase social tensions in a polarized society. Then, the duty of the companies is not fulfilled when they engage in moral talk. In polarized societies, the positional duty of businesses implies decreasing the risk of social conflict. It is not clear how to do that, yet I argue that if businesses use moral talk with mass marketing strategies, they would strive to shape impartial moral messages aiming to find points of moral convergence among polarized moral positions, which might mitigate social polarization. I call this duty the imperative of doux commerce.
Integrated procurement and reprocessing planning for reusable medical devices with a limited shelf life
Authors: Rickers Steffen , Sahling Florian 
Published: January 2024

AbstractWe present a new model formulation for a multiproduct dynamic order quantity problem with product returns and a reprocessing option. The optimization considers the limited shelf life of sterile medical devices as well as the capacity constraints of reprocessing and sterilization resources. The time-varying demand is known in advance and must be satisfied by purchasing new medical devices or by reprocessing used and expired devices. The objective is to determine a feasible procurement and reprocessing plan that minimizes the incurred costs. The problem is solved in a heuristic manner in two steps. First, we use a Dantzig-Wolfe reformulation of the underlying problem, and a column generation approach is applied to tighten the lower bound. In the next step, the obtained lower bound is transformed into a feasible solution using CPLEX. Our numerical results illustrate the high solution quality of this approach. The comparison with a simulation based on the first-come-first-served principle shows the advantage of integrated planning.
Trends in Bullying Victimization and Social Unsafety for Sexually and Gender Diverse Students
Authors: Kiekens W. J. , Van der Ploeg R. , Fish J. N. , Salway T. , Kaufman T. M. L. , Baams L. 
Published: January 2024

AbstractResearch has documented trends in bullying victimization for sexually diverse adolescents in the US, but trends regarding school social unsafety are understudied and there is a dearth of research examining these trends for gender diverse adolescents. This study aimed to identify disparities in bullying victimization and feelings of social unsafety in schools for sexually and gender diverse adolescents. Data stem from the 2014 (N = 15,800; M age = 14.17, SD = 1.50), 2016 (N = 22,310; M age = 14.17, SD = 1.49), and 2018 (N = 10,493; M age = 14.02, SD = 1.52) survey cycles of the Social Safety Monitor, a Dutch cross-sectional school-based study. Findings indicate that sexual orientation disparities remained relatively small, but stable over time, while gender diverse adolescents remained more likely to be victimized and feel unsafe in school, with larger disparities overall. Monitoring these trends is highly relevant, especially considering recent negative developments regarding societal acceptance of sexual and gender diversity.
Evidence of SARS-CoV-2 infection in companion animals from owners who tested positive for COVID-19 in the Valley of Mexico
Authors: Fernández-Figueroa Edith A. , Espinosa-Martínez Deborah V. , Miranda-Ortiz Haydee , Ruiz-García Erika , Figueroa-Esquivel Juan M. , Becerril-Moctezuma Miriam L. , Muñoz-Rivas Anallely , Ríos-Muñoz César A. 
Published: January 2024

Abstract

Background
Little is known about the companion animals which tested positive in Mexico for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Due to this, it is that we have documented the infection of companion animals, via an exploratory approach in two localities of the Valley of Mexico, in which the companion animal owners tested positive for COVID-19.

Methods
Oropharyngeal and nasopharyngeal swabs were collected from 21 companion animals. Also, a Reverse-Transcription Quantitative Polymerase Chain Reaction was used to test five probes in three SARS-CoV-2 genes. More than one-third (5/14) of these samples were positive for SARS CoV-2 corresponding to dogs.

Results
This research translates into the first available report on companion animals with SARS-CoV-2 infection in the most populated area of Mexico. Samples were added chronologically to previous reports prepared in other areas of the country, from February through November 2022.

Conclusion
Although SARS-CoV-2 infection in dogs is not as common as in other animals, our results suggest that it can be transmitted to dogs by their owners to a greater extent than previously reported.
Towards a general user model to develop intelligent user interfaces
Authors: Gaspar Alberto , Gil Miriam , Panach José Ignacio , Romero Verónica 
Published: January 2024

AbstractThe way end-users interact with a system plays a crucial role in the high acceptance of software. Related to this, the concept of Intelligent User Interfaces has emerged as a solution to learn from user interactions with the system and adapt interfaces to the user’s characteristics and preferences. However, existing approaches to designing intelligent user interfaces are limited by their user models, which are not capable of representing each and every user characteristic valid for any context. This work aims to address this limitation by presenting a user model that can abstractly represent a wide set of user characteristics in any context of interaction. The model is based on a synthesis of previous works that have proposed specific user models. After the analysis of these works, a more sophisticated user model has been defined, including some required characteristics not existing in previous works. This model has been validated with 62 real end-users who have expressed the users’ characteristics that they consider as relevant to adapt the interaction. The results show that most of these characteristics can be represented by the proposed user model. This user model is the first step towards creating intelligent user interfaces that can adapt interactions to users with similar characteristics and preferences in similar contexts.
How do referees integrate evaluation criteria into their overall judgment? Evidence from grant peer review
Authors: Hug Sven E. 
Published: January 2024

AbstractLittle is known whether peer reviewers use the same evaluation criteria and how they integrate the criteria into their overall judgment. This study therefore proposed two assessment styles based on theoretical perspectives and normative positions. According to the case-by-case style, referees use many and different criteria, weight criteria on a case-by-case basis, and integrate criteria in a complex, non-mechanical way into their overall judgment. According to the uniform style, referees use a small fraction of the available criteria, apply the same criteria, weight the criteria in the same way, and integrate the criteria based on simple rules (i.e., fast-and-frugal heuristics). These two styles were examined using a unique dataset from a career funding scheme that contained a comparatively large number of evaluation criteria. A heuristic (fast-and-frugal trees) and a complex procedure (logistic regression) were employed to describe how referees integrate the criteria into their overall judgment. The logistic regression predicted the referees’ overall assessment with high accuracy and slightly more accurately than the fast-and-frugal trees. Overall, the results of this study support the uniform style but also indicate that the uniform style needs to be revised as follows: referees use many criteria and integrate the criteria using complex rules. However, and most importantly, the revised style could describe most—but not all—of the referees’ judgments. Future studies should therefore examine how referees’ judgments can be characterized in those cases where the uniform style failed. Moreover, the evaluation process of referees should be studied in more empirical and theoretical detail.
Probabilifying reflective equilibrium
Authors: Dellsén Finnur 
Published: January 2024

AbstractThis paper aims to flesh out the celebrated notion of reflective equilibrium within a probabilistic framework for epistemic rationality. On the account developed here, an agent’s attitudes are in reflective equilibrium when there is a certain sort of harmony between the agent’s credences, on the one hand, and what the agent accepts, on the other hand. Somewhat more precisely, reflective equilibrium is taken to consist in the agent accepting, or being prepared to accept, all and only claims that follow from a maximally comprehensive theory that is more probable than any other such theory. Drawing on previous work, the paper shows that when an agent is in reflective equilibrium in this sense, the set of claims they accept or are prepared to accept is bound to be logically consistent and closed under logical implication. The paper also argues that this account can explain various features of philosophical argumentation in which the notion of reflective equilibrium features centrally, such as the emphasis on evaluating philosophical theories holistically rather than in a piecemeal fashion.
More tree growth reduction due to consecutive drought and its legacy effect for a semiarid larch plantation in Northwest China
Authors: Wan Yanfang , Yu Pengtao , Wang Yanhui , Li Jiamei , Bai Yushi , Yu Yipeng , Liu Bingbing , Wei Xiaocha 
Published: January 2024

AbstractExtreme climate has increasingly led to negative impacts on forest ecosystems globally, especially in semiarid areas where forest ecosystems are more vulnerable. However, it is poorly understood how tree growth is affected by different drought events. In 2006–2009, the larch plantations in the semiarid areas of Northwest China were negatively affected by four consecutive dry years, which was a very rare phenomenon that may occur frequently under future climate warming. In this study, we analyzed the effect of these consecutive dry years on tree growth based on the data of the tree rings in the dominant layer of the forest canopy on a larch plantation. We found that the tree-ring width index (RWI) in dry years was lower than that in normal years, and it experienced a rapidly decreasing trend from 2006 to 2009 (slope =  − 0.139 year−1, r =  − 0.94) due to water supply deficits in those dry years. Drought induced legacy effects of tree growth reduction, and consecutive dry years corresponded with greater growth reductions and legacy effects. Growth reductions and legacy effects were significantly stronger in the third and fourth consecutive dry years than that of single dry year (p < 0.05), which might have been due to the cumulative stress caused by consecutive dry years. Our results showed that larch trees experienced greater tree growth reduction due to consecutive dry years and their legacy effect, and the trees had lower recovery rates after consecutive dry years. Our results highlight that consecutive dry years pose a new threat to plantations under climate warming, and thus, the effect of climate extremes on tree growth should be considered in growth models in semiarid areas.
Dysregulation of micro-RNA 143-3p as a Biomarker of Carotid Atherosclerosis and the Associated Immune Reactions During Disease Progression
Authors: González-López Paula , Yu Yinda , Lin Shiying , Escribano Óscar , Gómez-Hernández Almudena , Gisterå Anton 
Published: January 2024

AbstractAtherosclerosis commonly remains undiagnosed until disease manifestations occur. The disease is associated with dysregulated micro(mi)RNAs, but how this is linked to atherosclerosis-related immune reactions is largely unknown. A mouse model of carotid atherosclerosis, human APOB100-transgenic Ldlr−/− (HuBL), was used to study the spatiotemporal dysregulation of a set of miRNAs. Middle-aged HuBL mice with established atherosclerosis had decreased levels of miR-143-3p in their carotid arteries. In young HuBL mice, early atherosclerosis was observed in the carotid bifurcation, which had lower levels of miR-15a-5p, miR-143-3p, and miR-199a-3p, and higher levels of miR-155-5p. The dysregulation of these miRNAs was reflected by specific immune responses during atheroprogression. Finally, levels of miR-143-3p were 70.6% lower in extracellular vesicles isolated from the plasma of patients with carotid stenosis compared to healthy controls. Since miR-143-3p levels progressively decrease when transitioning between early and late experimental carotid atherosclerosis, we propose it as a biomarker for atherosclerosis.
Graphical Abstract
Low levels of miR-143-3p in plasma extracellular vesicles can serve as a biomarker for atherosclerosis, and dysregulation of microRNAs is linked to the immune reactions associated with disease progression
Op welke manier kan datagedreven werken bijdragen aan meer doelmatigheid en kwaliteit in de langdurige zorg?
Authors: van den Berg Bellis , Lukkien Dirk , de Charro Felice , Snellen Margriet , Beelen Arjan , Bouwens Maartje 
Published: January 2024

SamenvattingHet systematisch gebruik van data-inzichten voor het verbeteren en onderbouwd beslissen, kan bijdragen aan het vergroten van de doelmatigheid en kwaliteit van zorg en leven. In de langdurige zorg staat datagedreven werken echter nog in de kinderschoenen. Ondanks succesvolle voorbeelden is het gebruik van data-inzichten nog niet structureel ingebed in werk- en besluitvormingsprocessen. Om hierin stappen te zetten is het nodig dat datagedreven werken niet wordt beschouwd als een (technisch) project, maar wordt het gezien als een veranderkundige opgave. Hiervoor is een gedegen visie op de betekenis van data in de organisatie van belang. Daarnaast dient aandacht te worden besteed aan verschillende samenhangende elementen, waarbij de drieslag richten, inrichten en verrichten helpend kan zijn.
Clinical presentation and antimicrobial resistance of invasive Escherichia coli disease in hospitalized older adults: a prospective multinational observational study
Authors: Doua Joachim , Rodríguez-Baño Jesús , Froget Rachel , Puranam Padma , Go Oscar , Geurtsen Jeroen , van Rooij Sanne , Vilken Tuba , Minoru Inage , Yasumori Izumi , Spiessens Bart , Tacconelli Evelina , Biehl Lena M. , Thaden Joshua T. , Sarnecki Michal , Goossens Herman , Poolman Jan , Bonten Marc , Ekkelenkamp Miquel ,   on behalf of the COMBACTE-NET Consortium/EXPECT Study Group, Violette Madison , Munshi Sonal , Aitabi Moussa , Lammens Christine , Van Mieghem Sofie , Van Puyvelde Sandra , Xavier Basil Britto , Azzini Anna Maria , Righi Elda , Salerno Nicola Duccio , Lo Giuliana , Cremonini Cascio Eleonora , Pascual Álvaro , Espíndola Reinaldo , Palomo Virginia , Walker Sarah , Ruffin Felicia , Dagher Michael , Varjačić Andreja 
Published: January 2024

Abstract
Background
Clinical data characterizing invasive Escherichia coli disease (IED) are limited. We assessed the clinical presentation of IED and antimicrobial resistance (AMR) patterns of causative E. coli isolates in older adults.

Methods
EXPECT-2 (NCT04117113) was a prospective, observational, multinational, hospital-based study conducted in patients with IED aged ≥ 60 years. IED was determined by the microbiological confirmation of E. coli from blood; or by the microbiological confirmation of E. coli from urine or an otherwise sterile body site in the presence of requisite criteria of systemic inflammatory response syndrome (SIRS), Sequential Organ Failure Assessment (SOFA), or quick SOFA (qSOFA). The primary outcomes were the clinical presentation of IED and AMR rates of E. coli isolates to clinically relevant antibiotics. Complications and in-hospital mortality were assessed through 28 days following IED diagnosis.

Results
Of 240 enrolled patients, 80.4% had bacteremic and 19.6% had non-bacteremic IED. One-half of infections (50.4%) were community-acquired. The most common source of infection was the urinary tract (62.9%). Of 240 patients, 65.8% fulfilled ≥ 2 SIRS criteria, and 60.4% had a total SOFA score of ≥ 2. Investigator-diagnosed sepsis and septic shock were reported in 72.1% and 10.0% of patients, respectively. The most common complication was kidney dysfunction (12.9%). The overall in-hospital mortality was 4.6%. Of 299 E. coli isolates tested, the resistance rates were: 30.4% for trimethoprim-sulfamethoxazole, 24.1% for ciprofloxacin, 22.1% for levofloxacin, 16.4% for ceftriaxone, 5.7% for cefepime, and 4.3% for ceftazidime.

Conclusions
The clinical profile of identified IED cases was characterized by high rates of sepsis. IED was associated with high rates of AMR to clinically relevant antibiotics. The identification of IED can be optimized by using a combination of clinical criteria (SIRS, SOFA, or qSOFA) and culture results.
Prospects of equitable and sustainable seaweed aquaculture: a case study of changing gender and socio-economic relations in Maullín, Chile
Authors: Fernández Gloria L. Gallardo , Avila Marcela , Saunders Fred , Riquelme Ricardo , Rodriguez Daniel , Aroca Gesica , Gutierrez Juan 
Published: January 2024

Abstract This article examines the development of marine tenure in the Maullín River, Chile. It starts with the emergence of artisanal red algae (Gracilaria chilensis) gathering and the changes resulting from the governmental ad hoc allocation of small-scale aquaculture concessions. We aim to track this transition, its drivers, effects on the work organization, gender relations, market relations and the sustainability/equity challenges currently confronting the community. We use a feminist political ecology approach to direct our multi-method data collection strategy and to analyse the empirical material. The State by enabling local tenure for the development of marine aquaculture concessions played an influential role in Maullín community attaining de facto territorial tenure. This led to the establishment of residential aquaculture communities while facilitating the integration of women in aquaculture activities. We see both steps as positive economic and social development opportunities in Maullín. While marine tenure has provided livelihood chances, low prices caused by the producers’ disadvantaged market position and the lack of supportive alliance building pose ongoing problems. We conclude that these factors are serious challenges to the sustainability of aquacultural livelihoods at Maullín River. While the case depicts aspects of women’s empowerment such as their engagement in developing potential post-production innovation ideas, entrepreneurial abilities to conduct market transactions as well as their better competence in literacy, math and financial expertise, there is still a long way to reach gender equality in the male-dominated aquacultural sector.