bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral Cortical-sparing Adrenalectomy for the Treatment of Bilateral Aldosterone-producing Adenomas
Authors: Nanba Kazutaka , Kaneko Hiroki , Mishina Mutsuki , Tagami Tetsuya 
Published: December 2023

Abstract
Aldosterone-producing adenoma (APA) is 1 of the major subtypes of primary aldosteronism (PA). Although most APA occurs unilaterally, bilateral APAs have rarely been documented. Because of its rarity, optimal management of patients with bilateral APAs has not been established. Here, we report a case of bilateral APAs that was successfully treated with simultaneous bilateral cortical-sparing surgery. A 44-year-old Japanese woman was referred to us for the evaluation of PA. She had typical clinical characteristics of PA, including hypertension, hypokalemia, and high plasma aldosterone concentration with suppressed renin. She was diagnosed as having PA based on the results of confirmatory testing. Computed tomography revealed bilateral adrenal nodules with diameters of 17 and 10 mm on the right and left adrenal gland, respectively. Adrenal venous sampling indicated excess aldosterone production from bilateral adrenal lesions. She underwent simultaneous bilateral laparoscopic partial adrenalectomy that normalized her blood pressure and serum potassium levels. Aldosterone synthase immunohistochemistry on the resected adrenal tumor tissue confirmed the diagnosis of bilateral APAs. Long-term postsurgical follow-up data suggest cure of the disease without the need for glucocorticoid replacement therapy. Bilateral cortical-sparing adrenalectomy appears to be a viable treatment option at least for selected patients with bilateral APAs.
Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism
Authors: Mitsuno Ryunosuke , Kaneko Kenji , Nakamura Toshifumi , Kojima Daiki , Mizutani Yosuke , Azegami Tatsuhiko , Yamaguchi Shintaro , Yamada Yoshitake , Jinzaki Masahiro , Kinouchi Kenichiro , Yoshino Jun , Hayashi Kaori 
Published: December 2023

Abstract

Context
Renal sinus fat (RSF) accumulation is associated with cardiometabolic diseases, such as obesity, diabetes, hypertension, and chronic kidney disease. However, clinical implications of RSF in primary aldosteronism (PA) remain unclear.

Objective
We aimed to investigate relationships between RSF volume and key cardiometabolic and renin-angiotensin system (RAS) parameters in PA patients and clarify the differences in these relationships between unilateral and bilateral subtypes.

Methods
We analyzed data obtained from well-characterized PA patients that involved 45 unilateral (median age: 52 years; 42.2% men) and 92 bilateral patients (51 years; 42.4% men).

Results
RSF volume normalized by renal volume (RSF%) was greater in the unilateral group than in the bilateral group (P &lt; .05). RSF% was greater in men than in women (P &lt; .05). RSF% positively correlated with parameters related to cardiometabolic risk, including age, body mass index, visceral fat volume, creatinine, triglycerides/high-density lipoprotein cholesterol ratio, uric acid, fasting glucose, and C-reactive protein regardless of PA subtypes (all P &lt; .05). Intriguingly, RSF% positively correlated with plasma aldosterone concentration (PAC), aldosterone-to-renin ratio, and intact parathyroid hormone (iPTH) (all P &lt; .05) in bilateral patients but did not correlate with RAS parameters and even showed an opposite trend in unilateral patients. In subgroup analyses by sex, these distinctions became more evident in women. After adjustment for potential confounders, RSF% remained positively correlated with PAC and iPTH in bilateral patients.

Conclusion
Our results indicate that RSF accumulation is involved in cardiometabolic dysfunction associated with PA. However, there were distinct correlations between RSF volume and RAS parameters according to sex and PA subtypes.
Artificial Intelligence in Anesthetic Care: A Survey of Physician Anesthesiologists
Authors: Estrada Alamo Carlos E. , Diatta Fortunay , Monsell Sarah E. , Lane-Fall Meghan B. 
Published: December 2023

BACKGROUND:
This study explored physician anesthesiologists’ knowledge, exposure, and perceptions of artificial intelligence (AI) and their associations with attitudes and expectations regarding its use in clinical practice. The findings highlight the importance of understanding anesthesiologists’ perspectives for the successful integration of AI into anesthesiology, as AI has the potential to revolutionize the field.

METHODS:
A cross-sectional survey of 27,056 US physician anesthesiologists was conducted to assess their knowledge, perceptions, and expectations regarding the use of AI in clinical practice. The primary outcome measured was attitude toward the use of AI in clinical practice, with scores of 4 or 5 on a 5-point Likert scale indicating positive attitudes. The anticipated impact of AI on various aspects of professional work was measured using a 3-point Likert scale. Logistic regression was used to explore the relationship between participant responses and attitudes toward the use of AI in clinical practice.

RESULTS:
A 2021 survey of 27,056 US physician anesthesiologists received 1086 responses (4% response rate). Most respondents were male (71%), active clinicians (93%) under 45 (34%). A majority of anesthesiologists (61%) had some knowledge of AI and 48% had a positive attitude toward using AI in clinical practice. While most respondents believed that AI can improve health care efficiency (79%), timeliness (75%), and effectiveness (69%), they are concerned that its integration in anesthesiology could lead to a decreased demand for anesthesiologists (45%) and decreased earnings (45%). Within a decade, respondents expected AI would outperform them in predicting adverse perioperative events (83%), formulating pain management plans (67%), and conducting airway exams (45%). The absence of algorithmic transparency (60%), an ambiguous environment regarding malpractice (47%), and the possibility of medical errors (47%) were cited as significant barriers to the use of AI in clinical practice. Respondents indicated that their motivation to use AI in clinical practice stemmed from its potential to enhance patient outcomes (81%), lower health care expenditures (54%), reduce bias (55%), and boost productivity (53%). Variables associated with positive attitudes toward AI use in clinical practice included male gender (odds ratio [OR], 1.7; P < .001), 20+ years of experience (OR, 1.8; P < .01), higher AI knowledge (OR, 2.3; P = .01), and greater AI openness (OR, 10.6; P < .01). Anxiety about future earnings was associated with negative attitudes toward AI use in clinical practice (OR, 0.54; P < .01).

CONCLUSIONS:
Understanding anesthesiologists’ perspectives on AI is essential for the effective integration of AI into anesthesiology, as AI has the potential to revolutionize the field.
Neurovascular Compression in Patients With Trigeminal Neuralgia May Be Associated With Worse Outcomes After Primary Percutaneous Rhizotomy
Authors: Nair Sumil K. , Al-Khars Hussain , Kalluri Anita , Ran Kathleen , Kilgore Collin , Budihal Bhargavi R. , Abdulrahim Mostafa , Yedavalli Vivek , Jackson Christopher M. , Huang Judy , Lim Michael , Bettegowda Chetan , Xu Risheng 
Published: December 2023

BACKGROUND AND OBJECTIVES:
Percutaneous rhizotomy may be an effective primary intervention in patients with trigeminal neuralgia who are poor candidates for microvascular decompression or those who desire a less invasive approach. However, the influence of neurovascular compression on pain-free survival after primary percutaneous rhizotomy is not well understood.

METHODS:
We retrospectively reviewed all patients undergoing percutaneous rhizotomy at our institution from 1995 to 2022. Patients were included if they had no history of surgical intervention, available preoperative MRI imaging, and postoperative follow-up data. Barrow Neurological Institute pain scores were assigned at various time points. We collected baseline patient information, pain characteristics, and perioperative complications for each patient. In addition, we recorded evidence of pain recurrence. Patients were dichotomized into those with evidence of neurovascular compression on preoperative MRI vs those without. The effect of neurovascular compression on pain-free survival was assessed using Kaplan-Meier Cox proportional hazards analyses.

RESULTS:
Of the 2726 patients reviewed, 298 met our inclusion criteria. Our study comprised 261 patients with no evidence of neurovascular compression on preoperative MRI vs 37 patients with evidence of neurovascular compression on preoperative MRI. Patients in the compression group had a shorter median duration to recurrence compared with those in the no compression group, P = .01. Kaplan-Meier survival analysis revealed that patients with preoperative evidence of neurovascular compression on MRI imaging demonstrated shorter pain-free survival compared with those without such evidence [hazard ratio = 1.57 (1.03-2.4), P = .037]. Cox proportional hazards analysis demonstrated that evidence of neurovascular compression was associated with poor pain-free survival [hazard ratio = 1.64 (1.06-2.53), P = .03].

CONCLUSION:
Patients with neurovascular compression on preoperative MRI may experience reduced time to recurrence compared with those without after percutaneous rhizotomy. These patients should be counseled on potential reduced efficacy of percutaneous rhizotomy as a primary intervention for their pain.
TASK-SERVICE AS A WAY TO IMPROVE THE WORK OF STAFF
Authors: Erygina Anna , Samohina E. 
Published: December 2023

This paper examines the concept of task-manager (or task-service) and what benefits it has for personnel, especially for HR, its advantages and disadvantages, as well as criteria for choosing the necessary service. In conclusion, examples of five worthy task-service with large internal functionality for effective work were reviewed and analyzed.
BUILDING A SYSTEMATIC APPROACH TO TRAINING PERSONNEL OF JSC «TRANSNEFT-URAL» IN TERMS OF PRODUCTION EQUIPMENT IMPORT SUBSTITUTION
Authors: Spirina L. , Stepanov I. 
Published: December 2023

At the moment, global geopolitical tensions have an impact on all areas of economic activity in the Russian Federation through the introduction of economic sectoral sanctions. Together with the reform of the education system, this entails an additional burden on the system of training qualified specialists in various sectors of the Russian economy. An acute shortage of specialists with the necessary knowledge, skills and abilities hinders the process of import substitution. As a result, to solve the problem of professional training of employees in the current economic conditions, a strategic model of professional training of personnel is proposed. The scientific novelty lies in the proposed model of a systematic approach to personnel training, based on the practical orientation of the proposed solutions and aimed at achieving a strategy for import substitution of production equipment of the JSC «Transneft-Ural» organization. The practical significance is the developed systematic approach to personnel training, which ensures the formation of competencies among the employees of the organization of JSC «Transneft-Ural», to work on new production equipment in the conditions of its import substitution.
Ensemble Variance Reduction Methods for Stochastic Mixed-Integer Programming and their Application to the Stochastic Facility Location Problem
Authors: Xu Jiajun , Sen Suvrajeet 
Published: December 2023

Sample average approximation (SAA), the standard approach to stochastic mixed-integer programming, does not provide guidance for cases with limited computational budgets. In such settings, variance reduction is critical in identifying good decisions. This paper explores two closely related ensemble methods to determine effective decisions with a probabilistic guarantee. (a) The first approach recommends a decision by coordinating aggregation in the space of decisions as well as aggregation of objective values. This combination of aggregation methods generalizes the bagging method and the “compromise decision” of stochastic linear programming. Combining these concepts, we propose a stopping rule that provides an upper bound on the probability of early termination. (b) The second approach applies efficient computational budget allocation for objective function evaluation and contributes to identifying the best solution with a predicted lower bound on the probability of correct selection. It also reduces the variance of the upper bound estimate at optimality. Furthermore, it adaptively selects the evaluation sample size. Both approaches provide approximately optimal solutions even in cases with a huge number of scenarios, especially when scenarios are generated by using oracles/simulators. Finally, we demonstrate the effectiveness of these methods via extensive computational results for “megascale” (extremely large scale) stochastic facility location problems. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Funding: This work was supported by The Office of Naval Research [Grant N00014-20-1-2077] and the Air Force Office of Scientific Research [Grant FA9550-20-1-0006]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2021.0324 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0324 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Shortening Emergency Medical Response Time with Joint Operations of Uncrewed Aerial Vehicles with Ambulances
Authors: Gao Xiaoquan , Kong Nan , Griffin Paul 
Published: December 2023

Problem definition: Uncrewed aerial vehicles (UAVs) are transforming emergency service logistics applications across sectors, offering easy deployment and rapid response. In the context of emergency medical services (EMS), UAVs have the potential to augment ambulances by leveraging bystander assistance, thereby reducing response times for delivering urgent medical interventions and improving EMS outcomes. Notably, the use of UAVs for opioid overdose cases is particularly promising as it addresses the challenges faced by ambulances in delivering timely medication. This study aims to optimize the integration of UAVs and bystanders into EMS in order to minimize average response times for overdose interventions. Methodology/results: We formulate the joint operation of UAVs with ambulances through a Markov decision process that captures random emergency vehicle travel times and bystander availability. We apply an approximate dynamic programming approach to mitigate the solution challenges from high-dimensional state variables and complex decisions through a neural network-based approximation of the value functions (NN-API). To design the approximation, we construct a set of basis functions based on queueing and geographic properties of the UAV-augmented EMS system. Managerial implications: The simulation results suggest that our NN-API policy tends to outperform several noteworthy rule- and optimization-based benchmark policies in terms of accumulated rewards, particularly for situations that are primarily characterized by high request arrival rates and a limited number of available ambulances and UAVs. The results also demonstrate the benefits of incorporating UAVs into the EMS system and the effectiveness of an intelligent real-time operations strategy in addressing capacity shortages, which are often a problem in rural areas of the United States. Additionally, the results provide insights into specific contributions of each dispatching or redeployment strategy to overall performance improvement. Funding: This work was supported by the National Science [Grant 1761022]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0166
Turning to religion as a mediator of the relationship between hopelessness and job satisfaction during the COVID-19 pandemic among individuals representing the uniformed services or working in professions of public trust in Poland
Authors: Jurek Krzysztof , Niewiadomska Iwona , Szot Leon 
Published: December 2023

Introduction
During the COVID-19 pandemic individuals performing uniformed service or working in a profession of public trust were particularly exposed to chronic stress. The exposure to stress contributes to a decrease in quality of life across various domains, including professional performance. The perceived mental difficulties can lead to a feeling of hopelessness which, in turn can generate a decrease in job satisfaction. Religiosity is a factor which, in stress-inducing conditions, not only stops the spiral of perceived resource losses but also triggers gains in the resources possessed.

Aim
The aim of the study was to assess the preference for positive religious coping strategies, namely turning to religion as a mediator for the relationship between perceived hopelessness and job satisfaction in the individuals declaring religiosity during the COVID-19 pandemic. The analysis has been performed based on the Conservation of Resources theory (COR).

Methods
The study encompassed 238 individuals representing the uniformed services or working in professions of public trust in Poland. The Inventory for Measuring Coping with Stress (MINI-COPE) and the Beck Hopelessness Scale (BHS) were used in the research.

Results
The mediating role of turning to religion in relationship between perceived hopelessness and job satisfaction was confirmed only in the group of women. The relationship found in this group indicates that perceived hopelessness is alleviated by turning to religion, which simultaneously leads to an increase in job satisfaction.

Conclusion
The obtained results prove that counselling should be standard practice after potentially traumatic events in the workplace; moreover, emotional and/or instrumental support should be offered along with spiritual one.
„Man macht natürlich Fehler“: Interview mit Petra-Sibylle Stenzel
Authors: Stenzel Petra-Sibylle 
Published: December 2023

Zusammenfassung
In einem Interview mit der langjährigen Leiterin der Hochschulbibliothek der HTW Dresden, Petra-Sibylle Stenzel, zum Thema Fehler und Scheitern reflektiert sie u. a. Fehlerkultur in ihrer Ausbildung, in ihrer Projekt- und Tagesarbeit und in ihrem Führungskraftalltag. Darin benennt sie auch eigene Fehler sowie fehlerpräventive Grundsätze.
Research progress of serum eosinophil in chronic obstructive pulmonary disease and asthma
Authors: Wu Congli 
Published: December 2023

AbstractChronic obstructive pulmonary disease (COPD) and asthma are common airway diseases, and there are similarities and differences between them. Serum eosinophil (EOS) has potential application value in the diagnosis, treatment, and prognosis of COPD and asthma. However, the clinical application value of serum EOS in these two diseases is controversial. In this work, recent research progress on the application of serum EOS in COPD and asthma was analyzed, and the potential application of serum EOS in the two diseases was expounded from several aspects, including the correlation between the pathogenesis of COPD and asthma and EOS, as well as the correlation between the diagnosis, treatment, and prognosis of the two diseases and serum EOS. The results revealed that serum EOS was important in the pathogenesis, diagnosis, treatment, and prognosis of COPD and asthma and exhibited a potential clinical application value. However, further study was needed to evaluate the threshold, which provided guidance for the clinical diagnosis and treatment of COPD and asthma.
Physicochemical properties and anthocyanin content of commercially manufactured elderberry jams from Patagonia (Argentina)
Authors: Baeza Rosa , Busso Carolina , Sanchez Virginia , López Paula , Chirife Jorge 
Published: December 2023

Abstract
Commercially manufactured elderberry jams elaborated in Patagonia, Argentina, were analyzed for physico-chemical characteristics. Water activity (a
w) ranged between 0.758 and 0.972 and total monomeric anthocyanin (TMA) content varied from 2.4 up to 55 mg Cy-3G/100 g jam. Relationship between a
w and °Brix in jams was described using an equation for correlating water activity in non-electrolyte solutions. Elderberry jam samples were stored at 38 °C and samples periodically withdrawn for analysis. TMA degraded following first order reaction kinetics and color parameter a* decreased during storage while parameter h° increased. Water activity and presence of fructose in jams increased rate of TMA destruction and adversely affected color changes. Studies with sugar solutions containing anthocyanins confirmed TMA degradation is faster in models having reducing sugars than in the presence of sucrose. It is shown that sucrose may undergo hydrolysis during acid catalyzed storage at 38 °C and pH 3.5.
Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
Authors: Di Zazzo Erika , Davinelli Sergio , Panichella Serena , Scapagnini Giovanni , Intrieri Mariano , Garofalo Silvio 
Published: December 2023

Abstract
Studies on the COVID-19 pandemic effects on gestational diabetes mellitus (GDM) remain limited and controversial. This study aimed to investigate the impact of the COVID-19 lockdown on the glycemic balance of pregnant women and GDM risk. To this aim, a single-center retrospective cohort analysis assessing glucose homeostasis using the oral glucose tolerance test in 862 pregnant women before (from March 9, 2019 to March 8, 2020 – Group 1), during (from March 9, 2020 to March 8, 2021 – Group 2), and after (from March 9, 2021 to March 8, 2022 – Group 3) the COVID-19 lockdown in Molise, a region of central Italy, was conducted. We observed that the blood glucose concentration of pregnant women was significantly lower during the COVID-19 lockdown than during the previous and following years at all time points evaluated (time 0, 60′, and 120′). Specifically, at time 0, it was 82.14 mg/dl for group 2 vs 85.94 for group 1 (p = 0.0001) and 85.87 for group 3 (p = 0.001). Similarly, at 60′, it was 121.38 mg/dl for group 2 vs 129.30 mg/dl for group 1 (p = 0.0029) and 131.68 mg/dl for group 3 (p = 0.0006). Moreover, at 120′, it was 104.20 mg/dl for group 2 vs 111.51 mg/dl (p = 0.0004) for group 1, and 116.06 mg/dl for group 3 (p = 0.0001). In contrast with previous findings, the COVID-19 lockdown was associated with an improved glycemic balance. Further studies are needed to better clarify the influence of lockdown restrictions on glucose metabolism and, consequently, on GDM risk.
Microstructure evolution and its effect on the impact toughness of the Ti-Al-V-Mo-Zr alloy tube
Authors: Chi Guangfang , Liu Huiqun 
Published: December 2023

AbstractTitanium alloys are widely used in the petrochemical industry owing to their excellent overall performance. In this study, a high-temperature solution treatment in the two-phase region was proposed, with a slow cooling rate resulting in the successful partial globularization of lamellar α microstructure, achieving an extruded Ti-Al-V-Mo-Zr alloy tube elongation increase of 69% and impact toughness increase of 51%. The kinking of lamellar α microstructure promoted its continuous globularization by increasing misorientation. Consequently, the elongation and impact toughness of Ti-Al-V-Mo-Zr alloy tubes could be greatly improved by tuning the microstructure to a mix of coarse equiaxed and lamellar α microstructures, the improved strength being attributed to the secondary α phase (αs) obtained using the proposed method and aging. The results of this study can be expected to provide guidance for the fabrication of highly ductile titanium-alloy oil-drilling tubes.
Graphical abstract