bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Risk Related to Glomerular Hyperfiltration in Nondiabetic
Individuals: Increasing Visibility is Crucial
Authors: Valtuille Rodolfo 
Published: November 2023

Abstract::
Glomerular hyperfiltration (GHF), defined by different estimation formulas, has been widely studied as a predictor of proteinuria and progression to chronic kidney disease (CKD) in diabetic patients. GHF is also an important cardiovascular (CV) risk factor and is related to all-cause mortality in non-diabetic populations; however, the upper limit of glomerular filtration rate (GFR) above which it indicates the presence of GHF is weakly defined. This higher risk is as high as in the intermediate stages of CKD and is greater than the presence of diabetes or smok-ing and is still present in non-albuminuria patients. The original Chronic Kidney Disease Epide-miology Collaboration (CKD-EPI) estimation GFR formula showed lower error at higher glo-merular filtration (GF) values, was the most used in population studies, and behaved as a better risk predictor. In our review (including approximately 3.6 million individuals), higher GFR val-ues related to increased mortality risk varied from 106.6 to 113.7 ml/min, which are usually not considered risk values for standard guidelines in non-albuminuric patients. However, the lack of consensus on a GF cutoff value, as well as its variability due to sex and progressive reduction with age, affect the knowledge of this serious phenomenon in clinical practice. Although the el-derly population is not exempted from the effects of GHF, the search for this phenomenon should be intensified in middle-aged populations because of their lower disease burden, where this situation may be more evident, and the possibility of reversing the consequences is greater. A population group often considered healthy includes obese people, essential hypertensives, smokers, and carriers of fatty liver, where the GHF phenomenon is frequent and is associated with CV disease, kidney disease, and higher mortality. Increasing its visibility by the medical community is essential to reduce the effects of GHF, emphasizing more frequent controls and implementing general measures that include strict control of hypertension, Na restriction, rich in vegetables diets and increased physical activity. Initiatives to confirm the beneficial effects of sodium-glucose cotransporter-2 inhibitors to treat isolated GHF would be an important break-through in reducing the severe consequences of this phenomenon.
The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical
Cancer
Authors: Najafi Sajad , Ghaedrahmati Farhoodeh , Abouali Gale Dari Mahrokh , Farzaneh Maryam , Mohammad Jafari Razieh 
Published: November 2023

Abstract:
Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the
fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease
influenced by various genetic, epigenetic, and environmental factors. While treatment options
such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains
poor due to high rates of distant and lymphatic metastasis. Recent research has shed light on the
role of non-coding RNAs (ncRNAs) in cervical cancer development, with circular RNAs
(circRNAs) emerging as a potentially significant regulator of cellular processes. Through targeting
miRNAs/mRNAs, circRNAs can impact cell growth and invasion in cervical cancer cells,
making them a promising biomarker for diagnosis and treatment. This review provides an overview
of the functional roles of circRNAs in the context of cervical cancer.
Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases
Authors: Sun Xieyin , Lin Zhaoyi , Xu Nuo , Chen Yinqi , Bian Saiyan , Zheng Wenjie 
Published: November 2023

:
Mesenchymal stem cells (MSCs) have been identified as potential therapeutics for various
diseases. In contrast to other sources of MSCs, dental stem cells (DSCs) have received increased
attention due to their high activity and easy accessibility. Among them, dental pulp stem
cells (DPSCs) exhibit superior self-renewal, multipotency, immunomodulatory, and regenerative
capacities. Following their inspiring performance in animal models and clinical trials, DPSCs
show pharmacological potential in regenerative medicine. In this review, we have generalized the
sources, heterogeneity, and biological characteristics of DPSCs, as well as compared them with
other types of dental stem cells. In addition, we summarized the application of DPSCs in digestive
diseases (such as liver, esophageal, and intestinal diseases), highlighting their regenerative and
pharmacological potential based on the existing preclinical and clinical evidence. Specifically, DPSCs
can be home to injured or inflamed tissues and exert repair and regeneration functions by facilitating
immune regulation, anti-inflammation, and directional differentiation. Although DPSCs
have a rosy prospect, future studies should handle the underlying drawbacks and pave the way for
the identification of DPSCs as novel regenerative medicine.
Development of 7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives Using
QSARINS Tool as BTK Inhibitors for the Treatment of Rheumatoid
Arthritis
Authors: Patil Shital M. , Asgaonkar Kalyani. D. , Magdum Pradnya , Chinde Vaishnavi , Edake Aishwarya , Naik Akshata 
Published: November 2023

Background:
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized
by inflammation of the joints, leading to pain, swelling, and joint deformity. Effective management
of RA involves the use of disease-modifying drugs that can slow down disease progression and
alleviate symptoms. Among the potential targets for RA treatment is Bruton's tyrosine kinase (BTK),
which plays a crucial role in B-cell signalling and contributes to the pathogenesis of RA.

Aim:
QSARINS (QSAR-INSUBRIA) is software used for the development and validation of Quantitative Structure-Activity Relationship (QSAR) analysis. In the present work, this software was explored for pharmacophore optimization of the pyrrolo-pyrimidine nucleus for anti-rheumatoid activity

Methods:
A series of pyrrolo-pyrimidine derivatives were used to build the QSAR models. These mod-els were generated to identify structural features that correlate significantly with the activity. We followed the assessment of statistical parameters to ensure thorough validation of all the QSAR models. The QSAR models demonstrating better statistical performance were selected, and descriptors of these models were analysed.

Results:
The results showed that the QSAR models were highly statistically robust and exhibited a
strong external predictive ability. Their structural features were also deduced.

Conclusion:
This QSAR study provided crucial information about the specific molecular features that can be used for the optimization of the pharmacophores. This research provides valuable insights into the structural features essential for BTK inhibition and paves the way for the design and development of novel anti-rheumatic agents targeting BTK in RA.
Natural Compounds as Inhibitors of Aβ Peptide and Tau Aggregation
Authors: Monteiro Kadja Luana Chagas , de Aquino Thiago Mendonça , da Silva-Júnior Edeildo Ferreira 
Published: November 2023

Abstract:
Neurodegenerative conditions like Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS) encompass disorders characterized by the degeneration of
neurons in specific circumstances. The quest for novel agents to influence these diseases, particularly
AD, has unearthed various natural compounds displaying multifaceted activities and diverse
pharmacological mechanisms. Given the ongoing extensive study of pathways associated with the
accumulation of neurofibrillary aggregates and amyloid plaques, this paper aims to comprehensively
review around 130 studies exploring natural products. These studies focus on inhibiting the formation
of amyloid plaques and tau protein tangles, with the objective of potentially alleviating or
delaying AD.
Development of Novel Spray-dried Microparticles to Treat Cystic Fibrosis:
A Tri-drug Approach
Authors: Kabra Vinayak D. , Lahoti Swaroop R. , Sugandhi Vrashabh V. 
Published: November 2023

Background:
Cystic fibrosis is the predominant autosomal recessive disorder known to
reduce life expectancy. Research findings indicate that around 60 to 70% of adult individuals with
this condition carry infections of Pseudomonas aeruginosa.

Objective:
The ongoing research investigates the potential synergy of merging ivacaftor and ciprofloxacin
to address bacterial infections.

Methods:
The two drugs were spray-dried into microparticles, which were then coated with Lsalbutamol
and were to be delivered by a dry powder inhaler. Microparticles were generated by applying
the spray drying method, utilizing bovine serum albumin and L-leucine in their preparation.
Additionally, L-salbutamol was mixed and adsorbed onto the surface of the spray-dried microparticles,
and it acted as a bronchodilator.

Results:
The microparticles produced via spray drying exhibited a particle size measuring 1.6 ±
0.04 μm, along with a polydispersity ratio of 0.33. Their zeta potential measured -27.3 ± 1.1 mV,
while the mass median aerodynamic diameter of these microparticles was 3.74 ± 0.08 μm. SEM,
XRD, and FTIR studies confirmed the entrapment of ivacaftor and ciprofloxacin. The morphology
was observed by SEM and TEM scans. Antibacterial synergy was confirmed through the agar broth
and dilution method, and the formulation's safety was established based on the outcomes of the
MTT assay.

Conclusion:
Using spray-dried microparticles containing ciprofloxacin, ivacaftor, and L-salbutamol
presents a novel approach to the treatment of cystic fibrosis.
Value of Electronic Health Records Measured Using Financial and Clinical Outcomes: Quantitative Study
Authors: Modi Shikha , Feldman Sue S , Berner Eta S , Schooley Benjamin , Johnston Allen 
Published: November 2023

Background
The Health Information Technology for Economic and Clinical Health Act of 2009 was legislated to reduce health care costs, improve quality, and increase patient safety. Providers and organizations were incentivized to exhibit meaningful use of certified electronic health record (EHR) systems in order to achieve this objective. EHR adoption is an expensive investment, given the resources and capital that are invested. Due to the cost of the investment, a return on the EHR adoption investment is expected.

Objective
This study performed a value analysis of EHRs. The objective of this study was to investigate the relationship between EHR adoption levels and financial and clinical outcomes by combining both financial and clinical outcomes into one conceptual model.

Methods
We examined the multivariate relationships between different levels of EHR adoption and financial and clinical outcomes, along with the time variant control variables, using moderation analysis with a longitudinal fixed effects model. Since it is unknown as to when hospitals begin experiencing improvements in financial outcomes, additional analysis was conducted using a 1- or 2-year lag for profit margin ratios.

Results
A total of 5768 hospital-year observations were analyzed over the course of 4 years. According to the results of the moderation analysis, as the readmission rate increases by 1 unit, the effect of a 1-unit increase in EHR adoption level on the operating margin decreases by 5.38%. Hospitals with higher readmission payment adjustment factors have lower penalties.

Conclusions
This study fills the gap in the literature by evaluating individual relationships between EHR adoption levels and financial and clinical outcomes, in addition to evaluating the relationship between EHR adoption level and financial outcomes, with clinical outcomes as moderators. This study provided statistically significant evidence (P<.05), indicating that there is a relationship between EHR adoption level and operating margins when this relationship is moderated by readmission rates, meaning hospitals that have adopted EHRs could see a reduction in their readmission rates and an increase in operating margins. This finding could further be supported by evaluating more recent data to analyze whether hospitals increasing their level of EHR adoption would decrease readmission rates, resulting in an increase in operating margins. Hospitals would incur lower penalties as a result of improved readmission rates, which would contribute toward improved operating margins.
THE RELATIONSHIP ANALYSIS BETWEEN ENVIRONMENTAL PERFORMANCE AND ECONOMIC VALUE OF THE COMPANY
Authors: Petrović-Ranđelović Marija , Stevanović Tatjana , Kostić Zorana 
Published: November 2023

The importance of environmental sustainability is becoming greater due to its contribution to greater value for customers and convergence of the circular economy and Industry 4.0, which can improve the efficiency of limited resource use. Based on the information from environmental accounting, managers can more effectively assess the economic impacts that corporate environmental performance generates on the company's operations. Environmental performance can be improved by developing new products and production processes in order to minimize the potential negative environmental impact. Many companies have introduced the practice of corporate self-regulation, which includes environmental management systems and reporting on the company's non-financial performance. The obtained results of the conducted empirical research could help managers make optimal decisions at the right time, and perform effective monitoring and rank of environmental and economic business indicators during the time.
Consumers’ attitude toward the source of biotechnology
Authors: Zhang Xumin , House Lisa , Karavolias Joanna , Gao Zhifeng , Briz Teresa , Haas Rainer 
Published: November 2023

Abstract
Existing research based on labels, risks and benefits, and cultural differences has focused on consumers’ preferences for genetically modified (GM) food products. Limited attention has been paid to the attitudes toward the source who developed the biotechnology. Because there may be trust issues associated with large multinational firms that are often involved in the development of biotechnology, it remains an unexplored question whether consumers consider who produces the technology when forming opinions about food produced with biotechnology. This study investigates consumers’ attitude toward the source of biotechnology using a choice experiment with GM oranges. The study involved participants from three major orange-consuming countries (United States, Germany, and Spain). Results reveal that participants from all three countries were less willing to pay for GM oranges when the technology originated from multinational agribusiness corporations, compared to public universities and small companies. Further examining the effect of consumers’ perceptions, we found consumers’ perception of corporate distrust and environmental concern negatively influence their attitude toward the source of biotechnology, but their technology acceptance positively affects the attitude. By understanding consumers’ attitudes about the source of biotechnology and factors that may improve the consumer reactions, communication and promotion of new biotechnology food products to improve acceptance from existing and potential consumers are discussed.
Getting started with digital literacy using pedagogic corpora in young learners’ english classes
Authors: Dutra Deise Prina , Marques Ana Lúcia 
Published: November 2023

This paper addresses the provision of instruction to teachers and learners on becoming digitally literate and skilled with corpus-based tools. It proposes the compilation of specific pedagogic corpora, in this case in Geography and Science, to be used in the English young learners’ classes in elementary education.The paper also illustrates the handling of user-friendly concordancer’s tools of #LancsBox 6.0 to perform basic analysis of the corpora language through a more accessible technology. It concludes by summarizing the possible benefits of an alternative approach to expose learners to customized corpus-informed language in English.
PERUBAHAN ORGANISASI PADA KANTOR PELAYANAN PENYULUHAN DAN KONSULTASI PERPAJAKAN (KP2KP) KOTA BANJAR
Authors: Rismawati Risa , Candradewini Candradewini , Sukarno Dedi 
Published: November 2023

Tujuan dari penelitian ini yaitu untuk menjelaskan bagaimana kesiapan KP2KP dalam melakukan perubahan organisasi yang terjadi dan upaya yang dilakukan untuk tetap memberikan pelayanan yang baik. Pada penelitian ini, penulis menggunakan metode penelitian dengan pendekatan kualitatif. Maka dari itu, untuk memperoleh data yang dibutuhkan penulis melakukan observasi dan wawancara dengan pegawai KP2KP Kota Banjar. Dimana teori yang digunakan sebagai rujukan penelitian yaitu oleh Porras dan Robertson dalam (Struckman & Yammarino, 2003). teori ini terdapat 9 faktor yaitu communication, culture, technology, leadership, management, organizational structure, performance management, strategy, skill. Hasil dari penelitian ini menjelaskan bahwa dari ke Sembilan faktor, ada beberapa faktor yang belum optimal namun dalam tahap perkembangan yaitu technology yang hanya sebagian layanan dapat dilakukan secara online, performance management sebagai upaya untuk lebih menarik wajib pajak dan wajib pajak kecil dilakukan penyuluhan langsung secara rutin. Dan ditemukan bahwa SDM masih dibawah rata-rata yang diharapkan untuk perubahan menjadi KPP Mikro dan cakupan wilayah yang masih kecil. Maka, dapat disimpulkan bahwa seluruh faktor dapat mempengaruhi perubahan organisasi. The purpose of this research that is for explain how KP2KP readiness in make changes organization that occurred and the efforts made for still give good service. On research this, author use method study with approach qualitative. So from it, for obtain the required data writer do observation and interview with Banjar City KP2KP employee. Where is the theory used as reference study namely by Porras and Robertson in (Struckman & Yammarino, 2003). theory This there are 9 factors that is communication, culture, technology, leadership, management, organizational structure, performance management, strategy, skills. Result of study This explain that from to the nine factors, there is a number of factors that are not yet optimal however in stage development that is technology that only part service can done in a manner online, performance management as effort for more collect must tax and mandatory tax small done counseling direct in a manner routine. And found that human resource still is below the expected average for change become a KPP Micro and the coverage area is still small.
INTRODUCTION TO CORN CROP (Zea mays Saccharata L.) PRODUCING BABY CORN AND FORAGE WITH VARIETIES AND HARVEST AGES IN CILELES VILLAGE, JATINANGOR DISTRICT, SUMEDANG REGENCY
Authors: Indriani Nyimas Popi , Mustafa Heryawan Kemal , Islami Romi Zamhir 
Published: November 2023

ABSTRACT The community service in Cileles Village aimed to increase insight through the knowledge and skills of farmers/breeders (Al Hikmah farmer group) about the use of corn plants as superior quality forage. The activity was carried out on Tuesday 19 July 2022 at Madrasah Al Hikmah RW 06 Cileles Village, Jatinangor District, Sumedang Regency. Community service was carried out using participatory empowerment methods which included counseling, mentoring and material assistance which actively involved the participation of the community in general and breeders in particular. The series of activities included: land preparation, planting and maintenance of corn plants. The corn used was a hybrid of various varieties of sweet corn (F1 Bonanza, F1 Janisa, F1Asia 86 and Sweet Lady). The corn seeds was planted in demonstration plots with a spacing of 70 cm x 20 cm. The conclusion from Community Service was that farmers/breeders became understand about the corn plants (Zea mays Saccharata L.) which produce baby corn and forage feed with various varieties and harvest ages. Farmers/breeders have planted the corn on the Al Hikmah farmer group’s fields.Keywords: Babycorn, forage,varieties, harvest ages
Efektivitas Game Epic Skater 2 Sebagai Media Simulasi Bermain Skateboard Menggunakan Konsep Fisika Kinematika 2 Dimensi
Authors: Nurul Fatihah  , Nikma Nurul Khomsati  , Bayu Setiaji  
Published: November 2023

Epic Skater 2 is a 3D skating game simulating skateboarding on various tracks by sliding and spinning to get maximum points. This study aims to analyze the concept of physics in kinematics material especially parabolic motion by analyzing the trajectory objects in the y direction in the Epic Skater game is it in accordance with the concept physics then concluded its effectiveness to be applied in skateboarding. The method used is an analysis using the tracker application. By using this software tracking data is represented in the graphical form y to t. Based on the research, the maximum height obtained in the epic skater game sequentially is 0,809 m ; 0,812 m ; 0,562 m ; 0,563 m, then averange height of 0,6865 m is obtained. The maximum height obtained on the skateboard game sequentially is 0,669 m ; 0,629 m ; 0,600 m ; 0,577 m, than an averange height of 0,61875 m is obtained.
Mobbing and its impact on health of nurses – a pilot study
Authors: Václavíková Klára , Kozáková Radka 
Published: November 2023

Abstract

Aim. The aim of this study was to determine the occurrence of mobbing and its health impacts on nurses in the selected hospital.

Method. The pilot study was performed from August to September 2020. The group consisted of 84 nurses (return was 56.0%), working in the acute care department in a selected medical facility. NAQ-R (Negative Acts Questionnaire-Revised) and GHQ-28 (General Health Questionnaire-28) tools were used.

Results. In total 10.50% of nurses experienced mobbing. Mobbing was targeted at the work-oriented and nurse-related areas. The most common descriptive phenomenon of mobbing is the assignment of tasks below the level of competencies. Nurses describing the occurrence of mobbing in the workplace more often reported feelings of constant tension, nervousness and pressure.

Conclusions. The occurrence of mobbing in the workplace can affect the health and cause mental and social problems of nurses.
Nurses’ views on and compliance with the guidelines of hand hygiene, including nail hygiene in a multi-profile hospital in Lesser Poland Province – the evidence for need of continuous education and training
Authors: Wałaszek Marta , Jaślan Dorota , Kołpa Małgorzata , Wójowska-Mach Jadwiga , Gniadek Agnieszka , Różańska Anna 
Published: November 2023

Abstract

Aim. The aim of this study was to examine the current situation and potential needs for education aiming at improving Polish nurses’ views and attitudes in terms of compliance with hand hygiene guidelines.

Material and methods. The study was based on a diagnostic survey method. A questionnaire based study and also visual evaluation of the nurses’ nails was carried out as well.

Results. Our results reveal unsatisfactory nurses’ attitudes and compliance with the given area of hand hygiene recommendations. Especially, despite the nurses’ strong support for natural nails, in practice they did not always comply with the guidelines.

Conclusions. It is necessary to develop and implement effective strategies of continuing education and training aiming at changing habits of healthcare workers, including nurses, in hand hygiene.