bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex disparity, prediagnosis lifestyle factors, and long-term survival of gastric cancer: A multi-center cohort study from China
Authors: Luan Xiaoyi , Zhao Lulu , Zhang Fan , Wang Wanqing , Jiao Fuzhi , Zhou Xiadong , Niu Penghui , Han Xue , Zhang Xiaojie , Zhao Dongbing , He Mingyan , Guan Quanlin , Li Yumin , Chen Yingtai 
Published: January 2024

Abstract

Background This multi-center cohort study aimed to investigate whether sex and prediagnosis lifestyle affect the prognosis of gastric cancer. Methods Patients with gastric cancer were from four gastric cancer cohorts of the National Cancer Center of China, The First Hospital of Lanzhou University, Lanzhou University Second Hospital, and Gansu Provincial Cancer Hospital. Prediagnosis lifestyle factors in our study included body mass index (BMI) at diagnosis, usual BMI, weight loss, the history of Helicobacter pylori (Hp) infection, and the status of smoking and drinking. Results Four gastric cancer cohorts with 29779 gastric cancer patients were included. In total patients, female patients had a better prognosis than male patients (HR = 0.938, 95%CI: 0.881–0.999, P = 0.046). For prediagnosis lifestyle factors, BMI at diagnosis, usual BMI and the amount of smoking were statistically associated with the prognosis of gastric cancer patients. Female patients with smoking history had a poorer survival than non-smoking females (HR = 0.782, 95%CI: 0.616–0.993, P = 0.044). Tobacco consumption > 40 cigarettes per day (HR = 1.182, 95%CI: 1.035–1.350, P = 0.013) was independent adverse prognostic factors in male patients. Obesity paradox was observed only in male patients (BMI < 18.5, HR = 1.145, 95%CI: 1.019–1.286, P = 0.023; BMI: 23-27.4, HR = 0.875, 95%CI: 0.824–0.930, P < 0.001; BMI ≥ 27.5, HR = 0.807, 95%CI: 0.735–0.886, P < 0.001). Conclusions Sex and some prediagnosis lifestyle factors, including BMI at diagnosis, usual BMI and the amount of smoking, were associated with the prognosis of gastric cancer.
Active avoidance under social conditions recruits the anterior cingulate cortex in male and female rats.
Authors: Ruble Shannon , Kramer Cassandra , West Lexe , Payne Karissa , Erickson Greg , Scott Alyssa , Diehl Maria 
Published: January 2024

Abstract

Actively avoiding potential threats is necessary for survival. Most research has focused on the behavioral and neurobiological processes when individuals avoid potential threats alone, under solitary conditions. Therefore, little is known about how social context affects active avoidance. Using a modified version of the platform-mediated avoidance task, we investigated whether the presence of a social partner attenuates freezing responses and promotes greater avoidance learning compared to avoidance learned under solitary conditions. Rats spent a similar percentage of time avoiding during the conditioned tone under both conditions; however, rats trained under social conditions exhibited greater freezing during the tone and lower pressing for food reward compared to solitary rats. Under solitary conditions, we observed greater avoidance in female compared to male rats, which was not present in rats under social conditions. To gain greater mechanistic insight, we optogenetically inactivated glutamatergic projection neurons in the anterior cingulate cortex (ACC) following avoidance training. Photoinactivation of ACC neurons impaired avoidance expression under social conditions both in the presence and absence of the partner. Under solitary conditions, photoinactivation of ACC delayed avoidance in males but blocked avoidance in females. Our findings suggest that avoidance is mediated by the ACC, regardless of social context, and may be dysfunctional in those suffering from trauma-related disorders. Furthermore, sex differences in prefrontal circuits mediating active avoidance warrant further investigation, given that females experience a higher risk of developing anxiety disorders.
Economic impact of metabolic dysfunction-associated steatotic liver (MASLD) in Italy. Analysis and perspectives
Authors: Torre Enrico , Matteo Sergio Di , Martinotti Chiara , Goglia Umberto , Bruno Giacomo Matteo , Testino Gianni , Rebora Alberto , Bottaro Luigi Carlo , Colombo Giorgio Lorenzo 
Published: January 2024

Abstract

Background: MASLD constitutes the ominous shadow of obesity and diabetes mellitus, destined to become pandemics for the coming decades. MASLD is a multisystem disease presenting an increased risk of developing cardio-nephrometabolic complications, extrahepatic tumors, and the obvious liver-related complications. Aim of our study is to evaluate the economic impact of MASLD among Italian population from the Italian National Healthcare Service (NHS) perspective.
Methods: MASLD economic impact was assessed developing a calculation model in Microsoft Excel®, from the Italian NHS perspective, considering healthcare resources and direct costs. Target population has been defined based on prevalence data. A literature search was conducted and the main MASLD-related complications were identified, corresponding to: MASH, with relative risk of evolution into CC, DCC, HCC, T2 diabetes mellitus, cardiovascular diseases, in particular MI and stroke, CKD, and CRC. It was chosen to evaluate the differential impact between complications development in the population with MASLD and in a same sample size population without-MASLD. Differential risk data, mortality rates and event unit costs were drawn from published international literature. Frequency and cost data were applied to the total target population, the total annual costs and mortality data, referring to the two arms, were then calculated and the differential value was obtained.
Results: Overall, based on an estimated 11,546,370 MASLD target population, an annual illness impact of €12,251,631,822 was calculated, corresponding to a difference of €7,731,674,054 compared to the same sample size without MASLD. Moreover, MASLD population is expected to result in 13,126 annual additional deaths.
Conclusion: The growing epidemiological impact of MASLD and its complications, will represent a huge economic burden for healthcare services worldwide. An holistic approach, mainly behaviors lifestyle change, to control the dramatic health and economic impact will be the first step to take. Specific drugs for MASLD are not yet available, but studies are underway, and combination pharmaceutical therapies may be an inevitable choice to achieve adequate control of MASLD and its complications in the future.
Predictive Score in Diagnosing Acute Colonic Diverticulitis at the Emergency Department: A retrospective study
Authors: Tantarattanapong Siriwimon , Glawsongkram Choasita , Pethyabarn Wasuntaraporn 
Published: January 2024

Abstract

Background: Acute diverticulitis was one of the common misdiagnoses among patients with acute abdominal pain in the emergency department (ED). The gold standard for diagnosing acute diverticulitis is a computerized tomography (CT) scan. Currently, no standard criteria have been established for diagnosing acute diverticulitis clinically. Therefore, the development of the predictive score for the diagnosis of acute diverticulitis will guide the physician in making a diagnosis and increase the appropriateness of the CT scan.
Method: A single-center retrospective study, conducted in adult patients aged more than 18 years who presented with acute abdominal pain at the ED, aimed to establish a predictive score for diagnosing acute diverticulitis. A multivariate logistic regression analysis was used to identify essential factors for the diagnosis of acute diverticulitis. The Akaike information criterion (AIC) was calculated to identify significant predictive factors for the probability of diagnosing acute diverticulitis and presented in a nomogram.
Results: There were 424 patients that fulfilled the inclusion criteria and 72 patients (17%) were diagnosed with acute diverticulitis. The significant predictive factors for the diagnosis of acute diverticulitis were age (adjust odd ratio (adj.OR) 1.03, 95% Confidence IntervaI (CI): 1.02-1.05), duration 24-72 hr (adj.OR 1.96, 95% CI: 0.97-3.95), duration >72 hr (adj.OR 3.22, 95% CI: 1.24-8.33), watery diarrhea (adj.OR 2, 95% CI: 0.97-4.15), nausea (adj.OR 0.43, 95%CI: 0.17-1.09), vomit (adj.OR 0.4, 95% CI: 0.11-1.38), right lower quadrant (RLQ) or left lower quadrant (LLQ) pain (adj.OR 3.48, 95% CI: 1.79-6.79), history of diverticulum (adj.OR 8.42, 95% CI: 3.61-19.63), LLQ tenderness (adj.OR 0.78, 95% CI: 0.36-1.7) and anorexia (adj.OR 0.23, 95% CI: 0.09-0.56). The seven clinical predictive variables for diagnosis acute diverticulitis of the nomogram consisted of 1) age, 2) nausea, 3) vomiting, 4) RLQ or LLQ pain, 5) duration of abdominal pain, 6) watery diarrhea, and 7) history of diverticulum. The total score of 135 was likely to diagnose acute diverticulitis with a sensitivity of 81.69% and a specificity of 70.94 %. The Area under the curve was 0.84. The secondary outcome, there were no signs, symptoms, or laboratory findings associated with complicated diverticulitis.
Conclusion: Significant predictive factors for diagnosis of acute diverticulitis were age, absence of nausea, absence of vomiting, RLQ or LLQ pain, duration of abdominal pain, watery diarrhea and history of diverticulum.
Post-nesting habitat selection by female loggerhead turtles Carreta caretta in Japan
Authors: Hayashi Haruka , Okamoto Kei , Ueno Shintaro , Ochi Daisuke 
Published: January 2024

Abstract

The number of nests of loggerhead turtle Carreta caretta in Japan has been declining in recent years and needs to be protected. Loggerheads spending most of time in foraging areas, it is important for their conservation to investigate their habitat and the environmental features that affect their habitat selection. During 2018 and 2019 nesting seasons, 23 nesting females were attached satellite transmitters at Tanegashima Island where is one of the largest nesting sites in Japan and tracked their post-nesting migration. Most inhabited the East China Sea (ECS) and Tsushima Strait, using three narrow areas in summer and moving to broader area in winter. Environmental factors and body size that may influence loggerhead’s habitat selections were compared for each highly used area and entire home range. Summer areas had relatively slower current compared to the surrounding. Wintering areas had faster currents but temperate. Primary productivity has not affected their habitat selection. Loggerheads using the most northern area were the largest of the three summer areas. Loggerheads select habitats in the ECS and Tsushima Strait that enable them to conserve their energy consumption, and that have comfortable temperatures. This result would be worth establishing their conservation measure.
Elevator Health Evaluation Based on Operational State Analysis and D-ANP Method
Authors: Chen Jiayan , Wang Yize , Feng Bin , Yu Ping , Feng Da 
Published: January 2024

Abstract

Elevator is an important part of modern life. A reasonable health evaluation plays an important role in avoiding elevator failures and ensuring the safety and normal operation of elevators. This paper establishes an index system for comprehensively evalu-ating the performance of elevators by analyzing the structure of elevators. The index system includes 11 detection indicators (including continuous and discrete indicators) that can fully evaluate the performance of elevators. By monitoring the running signals of elevators through professional elevator testing equipment and extracting multiple time-frequency features, different methods are used to evaluate discrete and continuous variables based on the different characteristics of different types of indi-cators: continuous variables are evaluated based on statistical quality control ideas, and discrete variables are evaluated based on standards and historical data, and the evaluation scores of each indicator are obtained. Finally, the laboratory decision-making network analysis method (D-ANP) is used to clarify the relationship between each indicator, calculate the weight of each indicator in the system, and obtain the comprehensive evaluation score of elevator health. And this evaluation model is applied to actual experimental applications, evaluating and assessing experimental elevators with different health levels, verifying the effectiveness of this model. The results show that the proposed method has good applicability and is expected to be applied to daily elevator maintenance and inspection, playing a promoting role in the field of elevator health evaluation and maintenance.
TLIF by Wiltse Approach versus OLIF for degenerative lumbar scoliosis: A retrospective study
Authors: Wang Fajia , Li Jianlei 
Published: January 2024

Abstract

To assess the differences in the clinical and radiological outcomes between Wiltse-TLIF and OLIF for treating degenerative lumbar scoliosis.In this retrospective controlled study, 65 patients with Lenke-Silva treatment level III, IV degenerative lumbar scoliosis. who were operated in our hospital from January 2018 and December 2022 were analyzed retrospectively. The patients were randomly assigned to Wiltse approach group (group A，31 cases) and conventional open approach group (group B，34 cases). Patient’s assessment of pain and disability were evaluated by the visual analogue scale (VAS) and the Oswestry disability index (ODI) before and after surgery. The incision length, operative time, intraoperative blood loss, hidden blood loss, time to ambulation, total length of hospitalization, X-rays, CT and MRI were also evaluated. There were no differences in sex, age, pre-operative ODI score, VAS score between the two groups (P > 0.05). The Wiltse approach group had a shorter incision length( 24.34vs. 31.51 cm, P＜0.05). The average operative time was shorter in OLIF group( 5.21 vs. 4.81 hours , P＜0.05). The OLIF group also have less intraoperative blood loss (672.32 vs. 370.11 ml, P＜0.001) and hidden blood loss (245.56 vs. 109.23 ml, P＜0.001). The Wiltse approach group were ambulatory(3.23 vs. 2.13 days, P＜0.05) and remained in the hospital(11.48 vs. 8.31 days, P＜0.05) for more time compared with OLIF group. Both groups showed no significant differences in the VAS scores of lower back and leg pain and the ODI scores. OLIF surgery is significantly better than Wiltse-TLIF in improving Sagittal vertical axis (t=2.13, P＜0.05) , lumbar lordosis (t=5.36, P＜0.001). There was no significant difference in the improvement of the lumbar cobb angle, Pelvic tilt angle and Sacral slope angle between the two groups.The complications rate was significantly lower in the Wiltse-TLIF group than in the OLIF group (23.5% vs. 12.9%).Wiltse-TLIF and OLIF showed similar patient-reported outcomes, however, the complication rate of OLIF was higher than that of Wiltse-TLIF, which do not adversely affect the clinical and radiographic outcomes. We also concluded that OLIF surgery is suitable for patients with dynamic raidcular pain, for the patients with static raidcular pain, wiltse-TLIF may be a better chosen.
NCX1/Ca2+ promotes autophagy and decreases bortezomib activity in multiple myeloma through non-canonical NFκB signaling pathway
Authors: Li Tingting , Xiao Pingping , Qiu Dongbiao , Yang Apeng , Chen Qingjiao , Lin Junfang , Liu Yao , Chen Junmin , Zeng Zhiyong 
Published: January 2024

Abstract

Although bortezomib (BTZ) is the cornerstone of anti-multiple myeloma (MM) therapy, the inevitable primary and secondary drug resistance still seriously affects the prognosis of patients. New treatment strategies are in need. Sodium-calcium exchanger 1 (NCX1) is a calcium-permeable ion transporter on the membrane, and our previous studies showed that low NCX1 confers inferior viability in MM cells and suppressed osteoclast differentiation. However, the effect of NCX1 on BTZ sensitivity of MM and its possible mechanism remain unclear. In this study, we investigated the effect of NCX1 on BTZ sensitivity in MM, focusing on cellular processes of autophagy and cell viability. Our results provide evidence that NCX1 expression correlates with MM disease progression and low NCX1 expression increases BTZ sensitivity. NCX1/Ca2+ triggered autophagic flux through non-canonical NFκB pathway in MM cells, leading to attenuated the sensitivity of BTZ. Knockdown or inhibition of NCX1 could potentiate the anti-MM activity of BTZ in vitro and vivo, and inhibition of autophagy sensitized NCX1-overexpressing MM cells to BTZ. In general, this work implicates NCX1 as a potential therapeutic target in MM with BTZ resistance and provides novel mechanistic insights into its vital role in combating BTZ resistance.
The application of a new model for disease classification in minimally invasive treatment of concomitant cholecystolithiasis and choledocholithiasis
Authors: Liu Yiwei , Xiao Yusha , Liu Pengpeng , Lan Jianwei , Song Dekun , Xie Longhui , Liu Quanyan 
Published: January 2024

Abstract

Background: The optimal minimally invasive treatment of concomitant cholecystolithiasis and choledocholithiasis is still variable.
Materials and Methods: This Chinese retrospective single-center cohort study for patients with concomitant cholecystolithiasis and choledocholithiasiss undergoing different minimally invasive treatments. A new model for disease classification was developed and the optimal treatment was screened.
Results: Diameter of CBD, stone number, stone size was significantly correlated with choice of minimally invasive surgical procedures. All patients were sorted into Type I, II, III and Ⅳ respectively. Two invasive surgical methods was performed in patients with type I, IO-EPBD+LC was more suitable due to shorter surgical and hospital stay, and lower postoperative serum amylase levels. There are five surgical methods was performed in patients with type II. If cystic duct was unobstructed and enough big to pass slender choledochoscopy when the confluence of the cystic duct and the common bile duct was slightly incised, the LC+LTCBDE group is recommended as the preferred treatment. IO-EPBD+LCshould be used if cystic duct was not blocked up but the caliber was not enough big to pass slender choledochoscopy. Among the four minimally invasive surgical methods for patients with type III, the LC+LCCBDE+Gastroscope group has the advantage of shorter hospital stay and fewer postoperative complications. Among the three methods for the type IV, the stones are too more and bigger to completely removed during the surgery, LC+LTCD is more suitable.
Conclusion: A novel simple clinical classification system would benefit to induct selecting minimally invasive surgical model for concomitant cholecystolithiasis and choledocholithiasis.
New quantitative measurement system for M2BPGi reveals liver inflammation complicates liver cirrhosis diagnosis
Authors: Uojima Haruki , Yamasaki Kazumi , Sugiyama Masaya , Kage Masayoshi , Ishii Norihiro , Shirabe Ken , Hidaka Hisashi , Kusano Chika , Murakawa Miyako , Asahina Yasuhiro , Nishimura Takashi , Iijima Hiroko , Sakamoto Kazumasa , Ito Kiyoaki , Amano Keisuke , Kawaguchi Takumi , Tamaki Nobuharu , Kurosaki Masayuki , Suzuki Takanori , Matsuura Kentaro , Taketomi Akinobu , Joshita Satoru , Umemura Takeji , Nishina Sohji , Hino Keisuke , Toyoda Hidenori , Yatsuhashi Hiroshi , Mizokami Masashi 
Published: January 2024

Abstract
Background/purpose of the study: Mac-2-binding protein glycosylation isomer (M2BPGi), a biomarker for liver fibrosis, is influenced by various etiologies. Here, we aimed to investigate clinical factors that improve the accuracy of liver cirrhosis (LC) diagnosis based on quantitative M2BPGi (M2BPGi-Qt), regardless of etiology.
Methods: In total, 1,373 patients with chronic liver disease (CLD) were recruited. Weassessed the correlation between fibrosis stage and M2BPGi-Qt levels among CLD etiologies. If there was no correlation between the fibrosis stage and M2BPGi level in a specific etiology of CLD, we evaluated the clinical factors influencing the M2BPGi-Qt level in that specific etiology. Subsequently, we created an algorithm to detect LC based on M2BPGi-Qt, considering an influencing factor other than fibrosis.
Results: In virus hepatitis, non-alcoholic fatty liver disease, and primary biliary cholangitis, the M2BPGi-Qt levels increased liver fibrosis progression. In autoimmune hepatitis, no significant association was observed between the fibrosis stage and M2BPGi-Qt level. However, liver inflammation positively correlated with the M2BPGi-Qt levels. Considering liver inflammation, we established an algorithm, M2BPGi-Qt, to determine the alanine aminotransferase-to-platelet ratio (MAP-R) in LC. The area under the receiver operating characteristic curve (AUC) of the MAP-R index was 0.840. The AUC of MAP-R was higher than that of the M2BPGi-Qt for detecting LC.
Conclusions: New quantitative measurement system for M2BPGi reveals liver inflammation complicates liver cirrhosis diagnosis. The algorithm based on the M2BPGi-Qt level demonstrates a high accuracy for LC diagnosis.
Glycolysis Related Genes in Osteoporosis: Screening for Potential Prevention Targets
Authors: Hu Xing-Bo , Yang Jing-Ze , Zhang Jin , Hu Jun , Yuan Xiao-Feng , Zhang Juan 
Published: January 2024

Abstract

Background
Osteoporosis is a metabolic bone disorder that globally affects more than 200 million people. Glycolysis seemingly important for bone resorption. We aimed to investigate glycolysis-related differentially expressed genes (GRDEGs) that might be potential targets for osteoporosis.
Methods
Differential expression analysis of GSE56815 from the Gene Expression Omnibus (GEO) database was performed. A Venn diagram was used to obtain the overlapping GRDEGs. The enrichment pathway analysis was performed and the hub genes were obtained. The abundance of immune cells was estimated utilizing the CIBERSORT algorithm.
Results
Utilizing the limma package and the Venn diagram, 154 GRDEGs were obtained. The GO and KEGG enrichment analysis of GRDEGs indicated several enriched terms related to regulation of JAK-STAT cascade and canonical glycolysis. As for GSEA enrichment analysis, they were significantly enriched in the NF_KB, glycolysis, Wnt and Hedgehog pathway. In the protein-protein interaction network, the hub differentially expressed genes, such as CTNNB1, HK3, MPI, HKDC1, PFKL, PTEN were obtained, which were correlated with the abundance of infiltrating T follicular helper cells. The hub genes MPI was significantly correlated with the invasion abundance of Macrophages M0 and Macrophages M2.
Conclusion
Our study reveals the potential role of GRDEGs in osteoporosis through bioinformatics analysis. The screened hub genes, CTNNB1, HK3, MPI, HKDC1, PFKL and PTEN might be therapeutic targets for patients with osteoporosis and novelly provide a theoretical basis for the early prevention of osteoporosis.
A case report of familial exudative vitreoretinopathy in a Chinese Family
Authors: Wang Yanan , Chang Yujie , Chai Yuqiong , Lei Hongtao , Yan Weiyan , Zang Weiwei 
Published: January 2024

Abstract
Background: Familial exudative vitreoretinopathy (FEVR) is an inherited disorder of retinal vascularization insufficiency caused primarily by genetic mutations. So far, FEVR has been less reported in the Chinese population. This study will provide a case of FEVR due to CTNNB1 splice mutation in a Chinese family, which will be helpful for genetic counseling and clinical diagnosis.
Case presentation: We analyzed a case of familial exudative vitreoretinopathy of Chinese Han origin using whole-exome sequencing. The results showed that the patient presents with neurodevelopmental disorders accompanied by spastic diplegia and visual impairment, as well as FEVR. Whole exome sequencing revealed a splicing mutation of c.1060+1G>A in the CTNNB1 gene of the patient. This may be the reason for the pathogenicity of FEVR observed in this patient. Our analysis indicates that this variant produces a truncated protein that contributes to the development of the disease. Genetic testing confirmed the FEVR diagnosis of patients from the study pedigree.
Conclusions: The c.1060+1G>A heterozygous mutation in the CTNNB1 gene can lead to FEVR disease, which expands the spectrum of CTNNB1 gene functional loss mutations in the Chinese population.