Development and Application of an Early Prediction Model for Risk of Bloodstream Infection based on Real-world Study
Authors: Hu Xiefei , Zhi Shenshen , Li Yang , Cheng Yuming , Fan Haiping , Li Haorong , Meng Zihao , Xie Jiaxin , Tang Shu , Li Wei 
Published: February 2025

Abstract

Background
Bloodstream Infection (BSI) is a severe systemic infectious disease that can lead to sepsis and Multiple Organ Dysfunction Syndrome (MODS), resulting in high mortality rates and posing a major public health burden globally. Early identification of BSI is crucial for effective intervention, reducing mortality, and improving patient outcomes. However, existing diagnostic methods are flawed by low specificity, long detection times and high demands on testing platforms. The development of artificial intelligence provides a new approach for early disease identification. This study aims to explore the optimal combination of routine laboratory data and clinical monitoring indicators, and to utilize machine learning algorithms to construct an early, rapid, and universally applicable BSI risk prediction model, to assist in the early diagnosis of BSI in clinical practice.
Methods
Clinical data of 2582 suspected BSI patients admitted to the Chongqing University Central Hospital, from January 1, 2021 to December 31, 2023 were collected for this study. The data were divided into a modeling dataset and an external validation dataset based on chronological order, while the modeling dataset was further divided into a training set and an internal validation set. The occurrence rate of BSI, distribution of pathogens, and microbial primary reporting time were analyzed within the training set. During the feature selection stage, univariate regression and ML algorithms were applied. First, Univariate logistic regression was used to screen for predictive factors of BSI. Then, the Boruta algorithm, Lasso regression, and Recursive Feature Elimination with Cross-validation (RFE-CV) were employed to determine the optimal combination of predictors for predicting BSI. Based on the optimal combination, six machine learning algorithms were used to construct an early BSI risk prediction model. The best model was selected by models’ performance, and the Shapley Additive Explanations (SHAP) method was used to explain the model. The external validation set was used to evaluate the predictive performance and generalizability of the selected model, and the research findings were ultimately applied in clinical practice.
Results
The incidence of BSI among inpatients at the Chongqing University Central Hospital was 12.91%. Following further feature selection, a set of 5 variables was determined, including white blood cell count, standard bicarbonate, base excess of extracellular fluid, interleukin-6, and body temperature. BSI early risk prediction models were constructed using six machine learning algorithms, with the XGBoost model demonstrating the best performance, achieving an AUC value of 0.782 in the internal validation set and an AUC value of 0.776 in the external validation set. This model is made publicly available as an online webpage tool for clinical use.
Conclusions
This study successfully identified a set of 5 features by analyzing routine laboratory data clinical monitoring indicators among hospitalized patients. Based on this set, a machine learning-based early risk prediction model for BSI was constructed. The model is capable of early and rapid differentiation between BSI and non-BSI patients. The inclusion of minimal risk prediction factors enhances its applicability in clinical settings, particularly at the primary care level. To further improve the model’s real-world applicability and more convenient for clinical use, the online application of the model could greatly improve the efficiency of BSI diagnosis and reducing patients’ mortality.