bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worcester Red Sox: Let's grow our brand
Authors: OHara Elizabeth , Leonard Bridget 
Published: September 2023

Research methodology
This case was developed through interviews with Brooke Cooper, Dr. Charles Steinberg and others at the WooSox, as well as a thorough analysis of the Worcester Red Sox’s social media and company websites.

Purpose
The purpose of this marketing case study is to This case focuses on understanding the process involved in conceptualizing and developing a marketing plan and strategy, and the ability to define and articulate the importance of BRAND in a marketing context.

Case overview/synopsis
The Pawtucket Red Sox relocated to Worcester, Massachusetts in Spring of 2019. The citizens of Worcester embraced their new team – the WooSox – as did many of the surrounding towns in Worcester County. The marketing arm of the WooSox worked tirelessly to develop a plan that included immersion in the cultures of the cities and towns within Worcester County; becoming a presence in their schools, businesses and community-based organizations; learning the priorities of the individual communities and supporting those needs; building a consistent, interactive and strong presence on social media; highlighting various interactions with their fan base; providing an outstanding experience at Polar Park; creating a loyal fan base ultimately driving ticket and merchandise sales and cultivating new fans to experience Polar Park; and understanding that word of mouth is the best form of marketing. The WooSox leadership team understood the need to expand its reach into new markets. In this case, the marketing team has been charged with exploring the Western Massachusetts region as a potential growth opportunity. The WooSox have a strong brand in the greater Worcester County area – but can they travel 60–90 min west and establish the same presence?

Complexity academic level
This case was written for undergraduate-level Marketing Principles or Sport Marketing courses.
Methodologies assessing digital technologies to assist “ageing in place”: a scoping review
Authors: Horne Francesca , Bailey Diane , Kenney Maggie 
Published: September 2023

Purpose
Despite continuing workforce challenges over the last decade, the social care system is considered a key enabler in keeping older people out of hospital. In response to the workforce challenges, White Paper was released, which acknowledged the opportunities afforded by digital technology to assist older people ageing at home, often supported by informal caregivers. Given the policy emphasis on digital-enabled care, the most appropriate methods for evaluating its impact on social care outcomes have yet to be determined. The purpose this study was to review the current literature using a systematic approach to understand the methodological limitations to inform more robust evaluations in their use in future research.

Design/methodology/approach
This scoping review used a systematic approach adopting the framework of Arksey and O’Malley to examine studies examining the adoption of digital technologies to assist in older people’s ability to age in place.

Findings
The 21 relevant studies identified on digital technology to assist ageing-in-place are evolving. To date, it has focused on the efficacy and usability of the digital technologies themselves rather than investigating the impact of such technologies on re/enablement outcomes for older people. To rebalance this emphasis, there needs to be more research investigating the factors that enhance useability of digital technologies by older people and exploiting narrative data gained from qualitative research as they can provide valuable insights.

Originality/value
To the best of the authors’ knowledge, this is the first scoping review to consider qualitative methodological approaches for exploring ageing in place.
Comparing approaches to identify live births using the Transformed Medicaid Statistical Information System
Authors: Auty Samantha G. , Daw Jamie R. , Admon Lindsay K. , Gordon Sarah H. 
Published: September 2023

AbstractObjectiveTo evaluate the performance of different approaches for identifying live births using Transformed Medicaid Statistical Information System Analytic Files (TAF).Data SourcesThe primary data source for this study were TAF inpatient (IP), other services (OT), and demographic and eligibility files. These data contain administrative claims for Medicaid enrollees in all 50 states and the District of Columbia from January 1, 2018 to December 31, 2018.Study DesignWe compared five approaches for identifying live birth counts obtained from the TAF IP and OT data with the Centers for Disease Control and Prevention (CDC) Natality data—the gold standard for birth counts at the state level.Data Collection/Extraction MethodsThe five approaches used varying combinations of diagnosis and procedure, revenue, and place of service codes to identify live births. Approaches 1 and 2 follow guidance developed by the Centers for Medicare and Medicaid Services (CMS). Approaches 3 and 4 build on the approaches developed by CMS by including all inpatient hospital claims in the OT file and excluding codes related to delivery services for infants, respectively. Approach 5 applied Approach 4 to only the IP file.Principal FindingsApproach 4, which included all inpatient hospital claims in the OT file and excluded codes related to infants to identify deliveries, achieved the best match of birth counts relative to CDC birth record data, identifying 1,656,794 live births—a national overcount of 3.6%. Approaches 1 and 3 resulted in larger overcounts of births (20.5% and 4.5%), while Approaches 2 and 5 resulted in undercounts of births (−3.4% and −6.8%).ConclusionsIncluding claims from both the IP and OT files, and excluding codes unrelated to the delivery episode and those specific to services rendered to infants improves accuracy of live birth identification in the TAF data.
Machine learning in clinical practice: Evaluation of an artificial intelligence tool after implementation
Authors: Akhlaghi Hamed , Freeman Sam , Vari Cynthia , McKenna Bede , Braitberg George , Karro Jonathan , Tahayori Bahman 
Published: September 2023

AbstractObjectiveArtificial intelligence (AI) has gradually found its way into healthcare, and its future integration into clinical practice is inevitable. In the present study, we evaluate the accuracy of a novel AI algorithm designed to predict admission based on a triage note after clinical implementation. This is the first of such studies to investigate real‐time AI performance in the emergency setting.MethodsThe novel AI algorithm that predicts admission using a triage note was translated into clinical practice and integrated within St Vincent's Hospital Melbourne's electronic emergency patient management system. The data were collected from 1 January 2021 to 17 August 2022 to evaluate the diagnostic accuracy of the AI system after implementation.ResultsA total of 77 125 ED presentations were included. The live AI algorithm has a sensitivity of 73.1% (95% confidence interval 72.5–73.8), specificity of 74.3% (73.9–74.7), positive predictive value of 50% (49.6–50.4) and negative predictive value of 88.7% (88.5–89) with a total accuracy of 74% (73.7–74.3). The accuracy of the system was at the lowest for admission to psychiatric units (34%) and at the highest for gastroenterology and medical admission (84% and 80%, respectively).ConclusionOur study showed the diagnostic evaluation of a real‐time AI clinical decision‐support tool became less accurate than the original. Although real‐time sensitivity and specificity of the AI tool was still acceptable as a decision‐support tool in the ED, we propose that continuous training and evaluation of AI‐enabled clinical support tools in healthcare are conducted to ensure consistent accuracy and performance to prevent inadvertent consequences.
Use of 16S rRNA gene sequences to identify cyanobacteria that can grow in far‐red light
Authors: Ko Jui‐Tse , Li Ying‐Yang , Chen Pa‐Yu , Liu Po‐Yu , Ho Ming‐Yang 
Published: September 2023

AbstractAlthough most cyanobacteria use visible light (VL; λ = 400–700 nm) for photosynthesis, some have evolved strategies to use far‐red light (FRL; λ = 700–800 nm). These cyanobacteria are defined as far‐red light‐utilizing cyanobacteria (FRLCyano), including two groups: (1) chlorophyll d‐producing Acaryochloris spp. and (2) polyphyletic cyanobacteria that produce chlorophylls d and f in response to FRL. Numerous ecological studies examine pigments, such as chlorophylls d and f, to investigate the presence of FRLCyano in the environment. This method is not ideal because it can only detect FRLCyano that have made chlorophylls d or f. Here we develop a new method, far‐red cyanobacteria identification (FRCI), to identify FRLCyano based on 16S rRNA gene sequences. From public databases and published articles, 62 16S rRNA gene sequences of FRLCyano were extracted. Comparing with related lineages, we determined that 97% sequence identity is the optimal cut‐off for distinguishing FRLCyano from other cyanobacteria. To test the method experimentally, we collected samples from 17 sites in Taipei, Taiwan, and conducted VL and FRL enrichments. Our results demonstrate that FRCI can detect FRLCyano during FRL enrichments more sensitively than pigment analysis. FRCI can also resolve the composition of FRLCyano at the genus level, which pigment analysis cannot do. In addition, we applied FRCI to published datasets and discovered putative FRLCyano in diverse environments, including soils, hot springs and deserts. Overall, our results indicate that FRCI is a sensitive and high‐resolution method using 16S rRNA gene sequences to identify FRLCyano.
Clinical characteristics and prognostic impact of acute exacerbations in patients with interstitial lung disease and lung cancer: A single‐center, retrospective cohort study
Authors: Hyun Dong‐gon , Han Soo Jin , Ji Wonjun , Choi Chang‐Min , Lee Jae Cheol , Kim Ho Cheol 
Published: September 2023

AbstractBackgroundAlthough acute exacerbation (AE) after treatment for lung cancer (LC) is a poor prognostic factor in patients with interstitial lung disease associated with lung cancer (ILD‐LC), the risk of AE according to cancer treatment type remains unclear. Therefore, in the present study, we aimed to investigate the association between AE and treatment received for LC in patients with ILD‐LC.MethodsWe conducted a retrospective study of patients with ILD‐LC who had undergone treatment for LC between January 2018 and December 2022. The primary study outcome was the incidence of AE within 12 months of treatment for LC according to treatment type. The association between AE and all‐cause mortality was evaluated as a secondary outcome.ResultsAmong a total of 137 patients, 23 (16.8%) developed AE within 12 months of treatment for LC. The incidence of AE according to treatment type was 4.3% for surgery, 16.2% for radiotherapy, 15.6% for chemotherapy, and 54.5% for concurrent chemoradiation therapy (CCRT). Patients who received CCRT were more likely to develop AE, even after adjustment for covariables (hazard ratio [HR], 15.39; 95% confidence interval [CI]: 4.00–59.19; p < 0.001). In addition, AE within 12 months of treatment for LC was associated with an increased risk of all‐cause mortality (HR, 2.82; 95% CI: 1.13–7.04; p = 0.026).ConclusionAmong treatment options for patients with ILD‐LC, CCRT was associated with an increased risk for AE. In addition, patients with AE had a higher mortality rate than patients without AE.
Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS
Authors: Xia Mengming , Song Xueyi , Lu Zebei , Wang Yu , Zhou Quan , Geng Peiwu , Wang Shuanghu , Zhou Yunfang , Wu Qingjun , Han Aixia 
Published: September 2023

AbstractBackgroundLenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole, voriconazole, isavuconazole and posaconazole) when orally administered to rats.MethodsA total of 30 Sprague–Dawley rats were randomly allocated into five groups and administered 20 mg/kg of ketoconazole, voriconazole, isavuconazole and 30 mg/kg of posaconazole and 0.5% CMC‐Na, through gavage for a duration of 7 days prior to the commencement of the experiment. On the final day, the rats were given 10 mg/kg of lenvatinib. The blood concentration of lenvatinib was determined using UPLC‐MS–MS. In vitro lenvatinib were incubated with azoles and rat liver microsomes (RLMs) or human liver microsomes (HLMs). Molecular docking was lastly used to examine the binding strength of the enzymes and ligands with Autodock Vina.ResultsAUC and Cmax of lenvatinib significantly increased with each of the azoles (p < 0.05), whereas CLz/F decreased 0.83‐flod, 0.41‐fold (p < 0.05) and 0.72‐fold (p < 0.01) in voriconazole, isavuconazole and ketoconazole in rats. The IC50 of lenvatinib with the azoles were 0.237, 1.300, 0.355 and 2.403 μM in RLMs and 0.160, 1.933, 3.622 and 1.831 μM in HLMs. Molecular docking analysis suggested that azoles exhibited a strong binding ability towards the target enzymes.ConclusionIt is imperative to acknowledge the potential drug–drug interactions mediated by CYP3A4 between azoles and lenvatinib, as these interactions hold significant implications for their clinical utilization.
Oviposition by the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), on five citrus types in a laboratory
Authors: Theron Charmaine D. , Kotzé Zanthé , Manrakhan Aruna , Weldon Christopher W. 
Published: September 2023

AbstractFrugivorous insects use visual, chemical and tactile cues to find a suitable host for oviposition. However, these cues can vary greatly among fruit cultivars and condition, changing their susceptibility to fruit fly oviposition. The aims of this study were to (1) determine the effects of ripeness stage and damage on oviposition propensity by sexually mature, mated female oriental fruit flies, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), on five citrus types (species and cultivars) under choice and no‐choice conditions and (2) describe the oviposition behaviour of B. dorsalis on ripe fruit of the same five citrus types that were either damaged or undamaged under no‐choice conditions. All tests were conducted in the laboratory. The citrus types tested were Citrus sinensis (L.) Osbeck cv Delta Valencia orange, Citrus sinensis (L.) Osbeck cv Glen Ora Late navel orange, Citrus limon (L) (Burm.f.) cv Eureka lemon, Citrus paradisi (Macfad.) cv Star Ruby grapefruit and Citrus reticulata (Blanco) cv Nadorcott mandarin. Peel physical properties and essential oil composition were determined for each citrus type and stage. Oviposition propensity of B. dorsalis was significantly greater on damaged citrus but was not correlated with fruit diameter, peel thickness, oil gland density or oil gland size. A total of 45 aromatic compounds were found to be significant between the five cultivars investigated, and 6 of 11 compounds were significantly associated with over‐ripe fruits. Bactrocera dorsalis spent a significantly greater proportion of time ovipositing in damaged citrus and showed higher aggression when oviposition occurred in undamaged citrus. These results suggest that the removal of damaged and fallen fruit is important for controlling this pest in citrus orchards.
Racgap1 knockdown results in cells with multiple cilia due to cytokinesis failure
Authors: Basu Basudha , Lake Alice V. R. , China Becky , Szymanska Katarzyna , Wheway Gabrielle , Bell Sandra , Morrison Ewan , Bond Jacquelyn , Johnson Colin A. 
Published: September 2023

AbstractMost mammalian cells have a single primary cilium that acts as a signalling hub in mediating cellular functions. However, little is known about the mechanisms that result in aberrant supernumerary primary cilia per cell. In this study, we re‐analysed a previously published whole‐genome siRNA‐based reverse genetic screen for genes mediating ciliogenesis to identify knockdowns that permit multi‐ciliation. We identified siRNA knockdowns that caused significant formation of supernumerary cilia, validated candidate hits in different cell‐lines and confirmed that RACGAP1, a component of the centralspindlin complex, was the strongest candidate hit at the whole‐genome level. Following loss of RACGAP1, mother centrioles were specified correctly prior to ciliogenesis and the cilia appeared normal. Live cell imaging revealed that increased cilia incidence was caused by cytokinesis failure which led to the formation of multinucleate cells with supernumerary cilia. This suggests that the signalling mechanisms for ciliogenesis are unable to identify supernumerary centrosomes and therefore allow ciliation of duplicated centrosomes as if they were in a new diploid daughter cell. These results, demonstrating that aberrant ciliogenesis is de‐coupled from cell cycle regulation, have functional implications in diseases marked by centrosomal amplification.
Adjuvant chemotherapy improves survival amongst octogenarians following resection of colorectal adenocarcinoma
Authors: Fernando Dhanushke , Hanna Joseph , Cohen Ryan , Ryan Jennifer 
Published: September 2023

AbstractBackgroundThe Australian population is ageing, with an increasing number of patients diagnosed with colorectal cancer in their eighth decade. This group represents a challenging cohort to deliver multidisciplinary care, with increased morbidity and mortality related to surgical and oncological therapies. This project aimed to compare surgical and oncological outcomes in octogenarian and non‐octogenarian patients with colorectal cancer.MethodsA matched case–control retrospective review of a prospectively maintained institutional database of colorectal cancer patients treated between 2005 and 2021 was conducted. Patient demographics, treatment details, peri‐operative complications, and long‐term survival were reported. The primary outcome, cancer‐specific survival, was investigated using time‐to‐event analysis and interrogated with multivariate regression.ResultsThere were 747 patients included in the study. There was no difference in five‐year cancer‐specific survival and recurrence‐free survival between cohorts. Multivariate analysis for octogenarians confirmed a significant hazard signal associated with worsening cancer stage and a survival benefit associated with the administration of adjuvant therapy. However, we noted that stage‐matched octogenarian patients received less adjuvant treatment compared to non‐octogenarians.ConclusionOctogenarians undergoing treatment for colorectal cancer have similar cancer‐specific survival and recurrence‐free survival to non‐octogenarians. Our study demonstrates a survival benefit when adjuvant therapy is provided to octogenarians, despite only half of this cohort receiving therapy compared to their younger peers. Further research into adjuvant therapy with surgical resection for CRC in older Australians is required.
Hard tissue stability outside the buccal bone arch contour after guided bone regeneration in the anterior maxilla: A retrospective cohort radiographic study
Authors: Gao Yang , Gao Shaojingya , Yao Yangxue , Cai Xiaoxiao 
Published: September 2023

AbstractObjectivesTo radiographically evaluate the stability of the bone substitute augmented outside the buccal bony arch contour in the maxillary esthetic zone.Materials and MethodsPatients who missed a single anterior tooth and received simultaneous GBR in implant surgery were included. The contralateral homonymous area of the implant site was horizontally mirrored as the individual bone arch contour. According to the relative position of the postoperative buccal grafts and bone arch contour at the implant shoulder, 62 patients were allocated into the outside‐contour (OC) and inside‐contour (IC) groups. Cone‐beam computed tomography was performed before surgery, after implant insertion, before re‐entry surgery, and at follow‐up. The profilometric changes of the buccal bone plate were analyzed via the bone distance to the mirrored bony contour.ResultsAt the implant shoulder, the bone distance in the OC group was higher than that in the IC group, with statistically significant differences at re‐entry surgery and follow‐up. However, the bone grafts outside the bone arch contour were reduced into the contour after remodeling and showed more bone resorption than the IC group. At other vertical levels below the implant shoulder, bony grafting of overcontour 1–2 mm range was favorable to regenerate stable bone plates reaching the individual contour at follow‐up.ConclusionsThe overaugmented bone outside the buccal bone arch contour tended to remodel into the original contour, which indicates that the anterior bone arch contour is worthy of careful observation for deciding buccolingual implant position and bone augmentation width.
A semantically enhanced text retrieval framework with abstractive summarization
Authors: Pan Min , Li Teng , Liu Yu , Pei Quanli , Huang Ellen Anne , Huang Jimmy X. 
Published: September 2023

AbstractRecently, large pretrained language models (PLMs) have led a revolution in the information retrieval community. In most PLMs‐based retrieval frameworks, the ranking performance broadly depends on the model structure and the semantic complexity of the input text. Sequence‐to‐sequence generative models for question answering or text generation have proven to be competitive, so we wonder whether these models can improve ranking effectiveness by enhancing input semantics. This article introduces SE‐BERT, a semantically enhanced bidirectional encoder representation from transformers (BERT) based ranking framework that captures more semantic information by modifying the input text. SE‐BERT utilizes a pretrained generative language model to summarize both sides of the candidate passage and concatenate them into a new input sequence, allowing BERT to acquire more semantic information within the constraints of the input sequence's length. Experimental results from two Text Retrieval Conference datasets demonstrate that our approach's effectiveness increasing as the length of the input text increases.
Classic biphasic pulmonary blastoma: A case report and review of the literature from 2000 to 2022
Authors: Yao Hui , Jiang Xin , Zeng Ying , Wang Xue , Tang Xuefeng 
Published: September 2023

AbstractClassic biphasic pulmonary blastoma (CBPB), a distinct type of lung cancer, is a dual‐phasic tumor characterized by the co‐existence of low‐grade fetal adenocarcinoma and primitive mesenchymal stroma. Accounting for less than 0.1% of surgically removed lung cancers, CBPB commonly presents in individuals during their fourth to fifth decades of life, with smoking as a significant risk factor. The optimal management strategy entails surgical resection, supplemented by chemotherapy to improve prognosis. The frontline chemotherapeutic agents typically include platinum agents and etoposide, with preoperative neoadjuvant chemotherapy potentially enabling operability for initially inoperable cases. In recent years, targeted therapies, such as antiangiogenic agents, have emerged as promising new treatment strategies for CBPB. For patients exhibiting brain metastases or deemed inoperable, radiation therapy proves to be a crucial therapeutic component. CBPB prognosis is adversely affected by factors such as early metastasis, tumor size exceeding 5 cm, and tumor recurrence. In this regard, serological markers have been identified as valuable prognostic indicators. To exemplify, we recount the case of a 44‐year‐old female patient with CBPB, wherein serum lactate dehydrogenase levels showed significant diagnostic value. This report further incorporates a comprehensive review of CBPB literature from the past 22 years.