bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioral capital: gaming and monetization in post-marxist perspective
Authors: Janoščík Václav 
Published: October 2023

Abstract
The most successful games today do not use a pay-for-product model, but involve complex and aggressive modes of monetizing their content (downloadable content, skins, in game currencies and markets, seasonal passes, etc.). While this has already been scrutinized, there are further consequences for games themselves and the economization of play. In my paper, I show how this strategy creates a conceptually novel situation, where playing can be considered to constitute reproductive labor-power and behavioral capital. In other words, playing here represents not only consumption but also the very production of such consumption, insofar as the main reason behind the massive success of these games is precisely their massive pool of players and data concerning their activity. Firstly, I analyse PUBG: Battlegrounds as an example of the most successful model of monetizing games and maintaining a large number of players and interaction. I focus both on the economic incentives as well as on the gameplay that is generated or tailored towards aggressive monetization. Later, I set a theoretical context for my analysis stemming from ludocapitalist discourse (itself combining Marx with poststructuralism) and the concept of surveillance capitalism. I conclude my text with a systematization and definition of my original concept of behavioral capital and an attempt to formulate art critique and usage of games as a form of cultural production exposing several examples from contemporary art.
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
Authors: Sun Yan , Jin Xin , Meng Junpeng , Guo Feng , Chen Taoyu , Zhao Xiaoyan , Wu Heshui , Ren Dianyun 
Published: October 2023

AbstractThe Hippo signaling axis is a tumor suppressor pathway that is activated by various extra‐pathway factors to regulate cell differentiation and organ development. Recent studies have reported that autophosphorylation of the core kinase cassette stimulates activation of the Hippo signaling cascade. Here, we demonstrate that protein arginine methyltransferase 5 (PRMT5) contributes to inactivation of the Hippo signaling pathway in pancreatic cancer. We show that the Hippo pathway initiator serine/threonine kinase 3 (STK3, also known as MST2) of Hippo signaling pathway can be symmetrically di‐methylated by PRMT5 at arginine‐461 (R461) and arginine‐467 (R467) in its SARAH domain. Methylation suppresses MST2 autophosphorylation and kinase activity by blocking its homodimerization, thereby inactivating Hippo signaling pathway in pancreatic cancer. Moreover, we also show that the specific PRMT5 inhibitor GSK3326595 re‐activates the dysregulated Hippo signaling pathway and inhibits the growth of human pancreatic cancer xenografts in immunodeficient mice, thus suggesting potential clinical application of PRMT5 inhibitors in pancreatic cancer.
AUTHENTIC CHEESES: MICROBIOLOGY, STARTERS, AND TECHNOLOGICAL ASPECTS OF PRODUCTION
Authors: Danylenko S. , Bondarchuk V. , Khablenko A. , Lukianets A. , Kozlovska G. , Kopylova K. 
Published: October 2023

The work is dedicated to the varieties, microbiological peculiarities and technological aspects of production of certain types of authentic cheeses. The purpose of work is to determine the microbiological peculiarities of authentic cheeses, to analyze their varieties and microbiota, to define the biotechnological peculiarities of production of certain types of authentic cheeses. Monographic, constructive, causal analysis and logical generalization methods were used. Cheese is the most popular food product in the world; there are 5,000 varieties of cheese. Although standard cheeses produced on large-scale productions are the most popular and widespread, authentic cheeses are also popular due to their unique organoleptic properties. Many factors influence the unique characteristics of authentic cheeses, the main of which are the quality of milk, its microbiological and chemical composition, and the technological methods used in cheese-making. All authentic cheeses are characterized by the presence of lactic acid bacteria, but the use of untreated milk sometimes leads to the presence of foodborne pathogens in the final product. Certain authentic cheeses have a complex microbiota, which complicates their production and the creation of starter cultures. However, for many cheeses, especially those like feta, there are now technological approaches to production, and most research is aimed at achieving an authentic taste and improving the organoleptic properties of the final product. Analysis of the quantitative and qualitative composition of the fermenting microbiota and the technological features of different types of traditional cheeses makes it possible to determine the composition of new fermenting compositions that are inherent to a particular product and to choose ways to increase the efficiency of cheese production.
Новые институциальные формы социального обслуживания: векторы развития
Authors: Старшинова Алевтина 
Published: October 2023

Негосударственные социально-­сервисные организации относятся к новым институциальным формам социального обслуживания. Их становление поддерживается и регулируется государством как институтом, ответственным за сферу общественного благосостояния. В статье рассмотрены государственные стратегии развития новых организаций – нормативно-­правовое закрепление статуса новых исполнителей социальных услуг, вторичная институциализация, социальное инвестирование и госу­дарственно-­частное партнерство (ГЧП), а также стратегии негосударственных организаций, складывающихся за счет гибридных форм, интеграции с другими НКО и социальными государственными учреждениями, инкорпорации в жилищные комплексы городской среды, при­менения инновационных / цифровых технологий социального обслуживания граждан. При этом каждая стратегия имеет свои преимущества и риски. Наше исследование показывает, что большинство региональных НКО ориентированы на финансовую и иную помощь государства. Немно­гочисленные, но более крупные и ресурсно-­обеспеченные организации во многом представляют собой результат гибридного развития и, как правило, первоначально создавались как коммерческие предприятия. Приобретая статус НКО при вхождении в сферу социальных услуг и получая доступ к бюджетному финансированию, такие организации продолжают заниматься предпринимательством для сохранения финансовой устойчивости, наращивая конкурентные преимущества. Направленность некоммерческих организаций на выполнение социальной миссии и одновременно ориентация некоторых из них на конкурентные отношения, выступающих в качестве игроков рынка социальных услуг, образуют два основных вектора развития новых участников производства общественных благ. Рассмотренный в статье кейс социально сервисной организации, инкорпорированной в жилой комплекс, характеризуется клиент-­ориен­тированностью, сочетающей черты гибридности и интегрированности, представляет перспективное направление развития негосударственных организаций социального обслуживания, реализация которого возможна в рамках государственно-­частного партнерства. Исследование проведено с помощью качественных методов в форме интервью, состоявшихся в 2022 г., с представителями НКО, ресурсных центров, государственного учреждения. Концепции совместного производства общественных благ, социального партнерства и межсекторного взаимодействия составили теоретическую основу проведенного исследования.
Актуальные проблемы формирования практик долговременного ухода за пожилыми людьми с деменцией
Authors: Мишеничев Константин , Бородкина Ольга 
Published: October 2023

Социально-­демографические процессы, связанные с ростом численности пожилых и людей с деменцией, требуют формирования новых подходов и внедрение иных практик социального обслуживания. Одной из наиболее востребованных практик ухода за пожилыми является система долговременного ухода (СДУ). За последние годы сделаны значительные шаги по улучшению инфраструктуры ухода за пожилыми людьми, в том числе создание правовой базы, развитие некоммерческого сектора и социального предпринимательства. В статье представлены результаты исследования развития системы долговременного ухода за пожилыми с деменцией. Основу эмпирического базы составили данные экспертных интервью (N=33), глубинных интервью с родственниками (N=20) и трех фокус-­групп с сотрудниками социальных служб. В ходе интервью и фокус-­групп обсуждались различные аспекты ухода за людьми с деменцией, в том числе как пожилые люди с деменцией становятся клиентами служб ухода; какие услуги они получают, какие формы ухода являются наиболее распространенными. Результаты исследования выявили трудности с оценкой нуждаемости пожилых с деменцией в уходе, связанные в том числе с организацией процесса оценки и поведенческими особенностями пожилых с деменцией. Одной из наиболее распространенных форм ухода за пожилыми с деменцией остается родственный уход, при этом в СДУ предусматриваются возможности по снижению нагрузки на родственников пожилых с деменцией. В настоящее время активно развивается уход в полустационарных учреждениях, однако им присущи проблемы недостаточного количества персонала для обеспечения безопасности пожилых с деменцией. В заключении подчеркивается, что в настоящее время наблюдается смещение фокуса социальной политики на нуждаемость различных групп пожилых, что сопровождается переходом к политике социального инвестирования. В сфере помощи людям с деменцией, помимо расширения сети специализированных стационарных и нестационарных учреждений, наблюдается развитие программ психологической помощи для людей с деменцией и лиц, осуществляющих уход, а также программ профессионального обучения в области гериатрической психиатрии.
УГОЛОВНО-ПРАВОВОЕ ОБЕСПЕЧЕНИЕ ИНФОРМАЦИОННОЙ БЕЗОПАСНОСТИ УМНОГО ГОРОДА КАК ОБЪЕКТА КИИ
Authors: ЖАРОВА Анна Константиновна 
Published: October 2023

Нарушение функционирования экосистемы умного города может привести к значительным негативным последствиям, например к остановке жизни города или всех промышленных предприятий. Информационные системы умного города являются весьма привлекательной целью для злоумышленников и все чаще подвергаются различным компьютерным атакам. Преступления против устойчивости функционирования умного города как объекта критической информационной инфраструктуры (КИИ) наносят существенный вред интересам государства, горожан и умного города как КИИ. В настоящее время этой проблеме не уделяется должного внимания, несмотря на формирование «института ответственности за преступления против информационной безопасности КИИ и информации, обрабатываемой в КИИ». В статье проведен криминологический анализ преступности в сфере компьютерной информации за период с 2017-го по 2022 г. Представлена статистика компьютерных атак на умный город за 2021 г. и первую половину 2022-го и статистика привлеченных к ответственности лиц за совершение компьютерных атак. Проанализированы негативные социальные явления, связанные с преступлениями против безопасности и устойчивости функционирования умного города как объекта КИИ. Анализ статистики привлечения к ответственности лиц за совершенные преступления, предусмотренные ст. 274.1 УК РФ, позволяет заключить, что наибольшее число преступлений связанных с причинением вреда КИИ РФ, совершаются группой лиц по предварительному сговору, или организованной группой, или лицом с использованием своего служебного положения (ч. 4 ст. 274.1 УК РФ). Привлечение к ответственности по ч. 5 ст. 274.1 УК РФ не осуществлялось в 2021 г. и в первой половине 2022 г., из чего можно сделать вывод, что, несмотря на сложную ситуацию в мире, атаки на КИИ РФ не приводили к тяжким последствиям.
Assessment of the management and outcome of neutropenia in paediatric haemato-oncology inpatients at Kenyatta National Hospital
Authors: Amadi Beatrice K. , Limungi Godfrey M. , Kezia Eunice M. , Khisa Abel O. 
Published: October 2023

Background: Neutropenia is a common complication among the haemato-oncology pediatric patients. Children who develop such complications are prone to bacterial infections which further predispose them to death. This study aimed at improving the practice of management of neutropenia in children with the view of reducing pediatric haemato-oncology mortality.
Methods: We retrospectively reviewed medical records of paediatric haemato-oncology inpatients aged 13 years and below, who developed neutropenia during treatment at Kenyatta National Hospital. A data abstraction form was used to collect data from 113 medical records of patients admitted between 1st January 2020 and 31st December 2020. Data were analyzed using R to obtain descriptive and inferential statistics using a 95% confidence interval.
Results: Boys constituted most of the cases assessed. The median (IQR) age at admission was 6 (4, 10) years. Leukaemias were more common than lymphomas. Acute lymphocytic leukaemia (59%) and Hodgkin’s lymphoma (4%) were the most and least frequently diagnosed haemato-oncology cancers. Most patients were diagnosed during the induction stage, 47 (42%) and had febrile neutropenia 59 (52%). Vaccination and bone marrow suppression histories were poorly documented. Thirty-three (29%) patients were reported to have succumbed during their treatment. G-CSF prescription was statistically significantly associated (p=0.045) with the survival status (death or alive) of patients, particularly at the induction stage (p=0.007).
Conclusions: Neutropenia management in KNH is done as per protocol, with room to improve on history taking. Although 29% of the children succumbed within the course of treatment, the majority (71%) of the patients were discharged.
The effect of cyriax soft tissue release and myofascial release on pain pressure threshold, flexibility and muscle length in idiopathic adhesive capsulitis- a comparative study
Authors: Makwana Ami , Mishra Neeti 
Published: October 2023

Background: Adhesive capsulitis has been reported to affect 2-5% of the general population and up to 11-30% of subjects with diabetes and thyroid disease. Both myofascial release technique and cyriax soft tissue release technique are effective in patients with adhesive capsulitis. Aims and objective were to assess the effect of cyriax soft tissue release and myofascial release on pain pressure threshold, flexibility and muscle length in idiopathic adhesive capsulitis - a comparative study.
Methods: In the present comparative study, total forty-eight (48) patients with Adhesive capsulitis with age between 40-60 years were included. They were randomly divided into two groups: group-A (n=24) and group-B (n=24). Both group received conventional treatment, in addition group-A received myofascial release technique and group-B received cyriax soft tissue release technique. Patients were evaluated pre-intervention (0 week) and post-intervention (4 week) for pressure pain threshold (by means of algometer), for muscle length (by means of measure tape) and for shoulder flexibility (by means of measure tape).
Results: Result showed that there was statistically significant difference between MFR group and cyriax group in mean difference of PPT, muscle length and Apley’s test during 4-week intervention period (p<0.05).
Conclusions: Cyriax along with conventional treatment is more effective for improving pressure pain threshold, improving muscle length and improving the flexibility of shoulder than myofascial release technique along with conventional treatment in patients with adhesive capsulitis.
Text neck: a modern concern
Authors: Badkur Seema , S. Keerthana , Kamble Mugdha , Shrivastava Shweta , Jain Nidhi 
Published: October 2023

Background: Nowadays, the mobile phone is the most popular and widely used device for various daily activities. Text neck used to describe neck discomfort and injury of upper back muscle which is caused by the frequent forward bending of neck at various angles, while staring down at a mobile phone. This should consider as “pain of the modern era” since it is caused by modern-era gadgets. The text neck syndrome is a growing health concern and has the potential to affect millions of people all over the world. The objectives of the study were to assess the burden of text neck syndrome and to find out the effect of neck disability on daily activities.
Methods: A cross sectional study was conducted among adults aged between 18-50 years from the general population using neck disability index questionnaire to gather information on how neck pain affected one’s ability to function in everyday life.
Results: Out of 691 responses, 95.8% were the mobile phone uses and 36.2% were on mobile phone for 5-7 hours per day. 27.4% were experiencing the mild neck pain. 45.6% of respondents reported mild text neck disability, 14.5% reported moderate, 3% reported severe and 0.4% reported complete text neck disability, and 36.5% did not suffer text neck disability.
Conclusions: A person’s life is incomplete without mobile phones, so that timely interpretation and interventions along with good knowledge about postural correction will be the key entities to deal with text neck syndrome.
Survival Rate Estimation in Patients with Colorectal Cancer by applying Fuzzy Product Limit Estimator
Authors: Khedrizadeh Galawezh , Jafari Koshki Tohid , Dolatkhah Roya , Mousavi Saeid 
Published: October 2023

Background: Survival rates are important to show the progress of the disease and the effect of treatments. The estimation of survival probabilities especially in presence of highly censored data is challenging. In this study, Fuzzy Product Limit Estimator (FPLE) is introduced to mitigate the challenge.
Methods: In a longitudinal study, data of 173 CRC patients were analyzed. To estimate survival probabilities, mean and median survival time, Fuzzy Product Limit Estimator (FPLE), a data-driven method, was applied to the data. It provides a smooth survival probability curve and the continuation of the survival curve is not a concern in the case while the largest observed time is censored.
Results: One-year survival rate for CRC patients was estimated to be 83% using FPLE and KM methods. The five-year survival rate was estimated to be 37% and 52% by the FPLE and KM methods, respectively. The largest observed time in data (71.96 months) was censored, so the survival rate after 71.96 months was not estimable by the KM method. But 10-year and 20-year survival rates were estimated by FPLE as 0.21 and 0.09. The mean (median) survival time was estimated 45.97 (65) and 82.69 (41.70) months by KM and FPLE methods, respectively.
Conclusion: In presence of highly censored survival data, the FPLE method provides acceptable estimates of CRC patients' survival rate. Also, the continuation of the survival curve was estimated after the largest observed time. The smaller estimates by the FPLE at 5-year could be considered as warning that the actual survival rate is lower than that reported by the KM method.
Aktivitas Aantioksidan Kombinasi Daun Sirsak (Anonna Muricata L.) dan Daun Beluntas (Pluchea Indica L.)
Authors: Hasanah Ulfatun , Inayah Nurul 
Published: October 2023

Soursop (Anonna Muricata L.) and Beluntas (Pluchea indica L.) are plants that contain secondary metabolites that have potential as antioxidants. The purpose of this study was to determine the activity of soursop leaf samples, beluntas and their combination in reducing DPPH. Samples were made into powder followed by maceration and evaporated the solvent to become an extract. Antioxidant activity testing with DPPH silencing method with UV-Vis spectrophotometer. Antioxidant activity test results for soursop leaf samples, beluntas, combinations (1:1), (1:2) and (2:1) have IC50 values of 58, 51, 57, 61 and 68 ppm, respectively. Further analysis Combination index of the combination (1:1) has a synergistic effect and the combination (1:2) and (2:1) has an antagonistic effect. Keywords: Antioxidant Activity, Anonna Muricata L. leaf, Pluchea indica L. leaf, DPPH
Modulatory Effects of Lawsonia inermis, Waltheria indica, Moringa oleifera and Nigella sativa on Haematology, Blood Pressure and Electrocardiographic Parameters of Wistar Rat Exposed to Acute Pain
Authors: Abdulfatai Aremu , Jiddah Idris Fatimah , Jimoh Akorede Ganiu , Afisu Basiru , Mistura Azeez Oyebisi 
Published: October 2023

Background: Pain is an obnoxious stimulus usually triggered by stressors that can affect homeostasis. The inability to sense pain is usually connected to abnormal fluctuations in normal body functions, leading to shortened life expectancy. Purpose: This study aimed to assess the effects of Lawsonia inermis, Waltheria indica, Moringa oleifera and Nigella sativa on hematology, electrocardiography, and blood pressure in Wistar rats experimentally exposed to acute pain. Methods:21 Adult female rats were divided into (1-7) of three rats each. Group 1 (negative control), group 2 (positive control), group 3 (Lawsonia inermis at 200 mg/kg), group 4 (Waltheria indica at 200 mg/kg), group 5 (Nigella sativa at 200 mg/kg), group 6 (Moringa oleifera at 200 mg/kg), and group 7 (Diclofenac at 10 mg/kg). Rats were dosed for 14 days, after which pain was induced. Result: The extracts showed non-significant increases in most hematological parameters, including PCV, RBC, and WBC counts, compared to positive controls. The effects of the extracts on the electrocardiographic parameters were not significant. Although the extract relieved pain, the effect of acetic acid on the heart was not completely ameliorated. The results of this study showed high blood pressure in untreated rats, which could be linked to pain induction. M. oleifera and W. indica exhibited minimal blood pressure-lowering effects. W. indica. and L. inermis showed transient blood pressure-lowering effects. Conclusion: This study concluded that the extract had a modulatory effect on hematology and a lowering effect on blood pressure and electrocardiac parameters in all treatments.