bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time‐weighted blood pressure with cardiovascular risk among patients with or without diabetes
Authors: Jiang Zhixin , Shao Fang , Hu Jingwen , Zhuang Qinyuan , Cooray Pestheruwe Liyanaralalage Rosemarrie Krisunika , Chen Kangyu , Wu Zhenqiang , Chen Tao , Li Chao 
Published: January 2024

AbstractBackgroundUsual measures of blood pressure (BP) do not account for both the magnitude and duration of exposure to elevated BP over time. We aimed to demonstrate the effect of a novel time‐weighted BP on cardiovascular outcomes using a post hoc analysis of two published randomized trials.HypothesisTime‐weighted blood pressure is associated with cardiovascular risk among patients with or without diabetes.MethodsThe limited‐access ACCORD and SPRINT data sets were used for the current study. Time‐weighted BP is obtained by dividing cumulative BP by the total follow‐up time. Time‐weighted BP burden above a threshold is also determined after deriving the time‐weighted BP by re‐zeroing the interpolated pressure values at two different hypertension thresholds (>140/90 and >130/80 mmHg).ResultsEighteen thousand five hundred forty‐one patients from the two clinical trials were enrolled in this study. A J‐curve relation was observed between time‐weighted BP and major cardiovascular events (MACE). The systolic blood pressure (SBP) burden independently predicted MACE across the two trials at different thresholds (ACCORD: SBP > 130 mmHg, HR = 1.05 [1.03−1.06]; SBP > 140 mmHg, HR = 1.06 [1.04−1.08]; SPRINT: SBP > 130 mmHg, HR = 1.04 [1.03−1.05]; SBP > 140 mmHg, HR = 1.05 [1.04−1.07]). Consistent results were found for diastolic blood pressure (DBP) burden (ACCORD: DBP > 80 mmHg, HR = 1.10 [1.06−1.15]; DBP > 90 mmHg, HR = 1.20 [1.11−1.30]. SPRINT: DBP > 80 mmHg, HR = 1.06 [1.02−1.09]; DBP > 90 mmHg, HR = 1.12 [1.06−1.18]). Significant associations were also observed for stroke, myocardial infarction, cardiovascular death, and all‐cause mortality.ConclusionBoth time‐weighted SBP and DBP independently influenced the risk of adverse cardiovascular events among patients with and without diabetes, regardless of the definition of hypertension (130/80 or <140/90 mmHg).
In‐silico and in‐vitro evidence suggest LINC01405 as a sponge for miR‐29b and miR‐497‐5p, and a potential regulator of Wnt, PI3K, and TGFB signaling pathways in breast carcinoma
Authors: Norouzi Romina , Mohamadzade Zahra , Norouzi Rambod , Norouzi Radin , Esmaeili Rezvan , Soltani Bahram M. 
Published: January 2024

AbstractBackgroundCarcinoma of the breast, a prevailing factor in female mortality worldwide, involves dysregulation of lncRNAs and microRNAs.AimThe main goal of this research was to predict and experimentally examine the LINC01405 expression status in breast cancer subtypes, along with investigation of its interaction with miR‐29b and miR‐497‐5p that results in regulating PI3‐Kinase, WNT, and TGF‐beta signaling pathways.Methods and ResultsWe performed a meta‐analysis of five GEO datasets, encompassing microarray and RNA‐seq data, to identify differentially expressed genes. The Cancer Genome Atlas transcriptome dataset was also analyzed to determine essential gene modules, associated with different stages of breast cancer by weighted gene co‐expression networks. In addition, networks of drug‐gene interactions were constructed to explore potential treatment options. LINC01405 as a microRNA sponge was chosen and examined. furthermore, downstream target genes were discovered.Experimental validation consisted of plasmid constructs used in cell culture experiments, RT‐qPCR for expression analysis, and cell cycle assays. Our bioinformatics findings showed higher LINC01405 expression in Basal‐like triple‐negative breast carcinoma. In contrast, lower expression in Luminal samples was observed compared with normal samples, which was consistently observed in both breast cancer tissues and cell lines. LINC01405 expression level was correlated with miR‐29b and miR‐497 levels. The MDA‐MB‐231 cell line demonstrated higher LINC01405 expression and lower miR‐29b and miR‐497 expression levels. However, SKBR3 and MCF7 cells had lower LINC01405 expression and higher miR‐29b and miR‐497 levels, suggesting a regulatory role for LINC01405 as a competing endogenous RNA. This was experimentally confirmed when LINC01405 was overexpressed in SKBR3 cells, and the common target genes of miR‐29b and miR‐497 were upregulated. Additionally, LINC01405 upregulation led to the increased cell populations, proliferation, and upregulation of critical cancer‐related genes, including AKT1, AKT3, mTOR, WNT3A, SMAD3, CYCLIN D1, CYCLIN D2, BCL2, and GSK3B.ConclusionWe revealed the differential expression of LINC01405 in several types of breast cancer and its role in regulating signaling pathways, potentially via scavenging miRNAs. These findings clarified the role of LINC01405 in breast cancer development and identified potential therapeutic targets.
Three‐phase step‐down AC/DC converter with sinusoidal pulse‐width modulation
Authors: Huang You‐Chun , Hsieh Yao‐Ching , Syu Zih‐Jin 
Published: January 2024

SummaryThis paper proposes a step‐down alternating current (AC)/direct current (DC) converter with current‐doubler rectification stage, therefore suitable for low‐voltage and high‐power applications. High power factor and low harmonic distortion can be achieved by simply applying sinusoidal pulse‐width modulation (SPWM) control. A laboratory prototype circuit rated at 2 kW, 180‐V output voltage is designed and built to verify the circuit feasibility. Experimental results confirm that the power factor is ubiquitously higher than 0.99 from 500 W to the full load. The total harmonic distortion at the full load is less than 5%, which meet the harmonic specifications of IEC 61000‐3‐2 and IEC 61000‐3‐12.
Every mistake is a treasure: Lessons learned from the TRIANGLE trial for anorexia nervosa
Authors: Ambwani Suman , Coull Eliza , Cardi Valentina , Rowlands Katie , Treasure Janet 
Published: January 2024

AbstractBackgroundDespite several decades of treatment research for anorexia nervosa (AN), many of the same questions remain: how to boost enrollment, engage participants, prevent attrition, and meet the needs of a diverse patient population within the rigorous framework of a randomized controlled trial (RCT).MethodsIn this research forum, we highlight some of the challenges and opportunities observed over the course of TRIANGLE, the largest RCT for severe AN treatment in the UK to date. We discuss strategies for addressing common challenges and avoiding common pitfalls and propose solutions to future researchers seeking to conduct treatment research in AN.ResultsOur experience underscores the value of involving people with lived experience at every stage of intervention research. We offer additional recommendations for treatment researchers, including, (1) early qualitative research to identify patient barriers and obstacles, (2) clear, systematic collaboration with clinical sites for patient recruitment and passive data collection, (3) careful consideration of assessment metrics, including repeated measurement of quality of life, (4) adopting a flexible, patient‐centered approach to clinical trial research, and (5) considering the unique needs and obstacles that might impact carer participation in research and their ability to provide support to their loved ones.DiscussionWe hope that these lessons learned will prove fruitful for the next generation of researchers embarking on treatment research for AN.Public SignificanceUsing the TRIANGLE trial as an illustrative case study, we highlight the value of lived experience and codesign for developing and testing interventions for AN. We offer several lessons learned over the course of the trial, pertaining to trial enrollment, retention and engagement, measurement of outcomes, and research adaptations for real‐world settings, and hope that these recommendations facilitate future treatment research for AN.
Synthesis, Luminescence and Relaxometric Properties of Macrocyclic Lanthanide Complexes Appended with an Imidazothiadiazole, a Heterocyclic Bioactive Scaffold
Authors: Ndiaye Modou , Caillet Emma , Eliseeva Svetlana V. , Masson Thibaut , Marchetti Luke A. , Pallier Agnès , Morfin Jean‐François , Petoud Stéphane , Routier Sylvain , Buron Frédéric , Bonnet Célia S. 
Published: January 2024

AbstractThe syntheses of two macrocycles containing original imidazothiadiazole heterocycles are presented. The protonation constants of the ligands have been determined by potentiometry and photophysical measurements. The photophysical properties of the corresponding Tb3+ complexes have been analyzed and the sensitization of the Tb3+ by the heterocyclic moiety demonstrated with modest quantum yields. The corresponding Gd3+ complexes are monohydrated and display higher relaxivities than GdDOTA, which could be explained by the larger size of these complexes. The different substitutions on the heterocycle do not affect strongly the protonation constants of the ligand, the quantum yield, water exchange rate or relaxation properties of the system.
Research on fuel injection characteristics of common rail system based on high pressure pipeline integration and matching
Authors: Xu Rui‐fan , Ma Fu‐kang , Li Liang‐yu , Yang Wei , Zhang Yi 
Published: January 2024

AbstractThe modular prediction model of high pressure common rail system was established to study the influence of high‐pressure pipeline integration matching on the fuel injection characteristics of common rail system. The influence of common rail volume on pressure building and pressure fluctuation in common rail tubes was analyzed. The influence of common rail volume on the matching of fuel injection frequency (number of fuel injectors) and fuel supply frequency (number of plunger pumps) was studied by using the control variable method, and the basic optimal solution of the system was obtained. The influence of the common rail structure on the fuel flow characteristics of the system was also studied. The matching relationship between high pressure tubing and common rail system is studied by introducing dimensionless numbers such as length‐diameter ratio of pipeline. The results demonstrate that the increase of the storage space of the accumulator can effectively reduce the fluctuation in the system, so that the injection volume increases slowly and then decreases rapidly, with a slope of −5.70 × 10−3 mm3. The increase of the diameter of the common rail makes the fuel flow characteristics become good first and then bad, and the increase of the length of the common rail can soothe the pressure fluctuations. The increase of the diameter of the link tube (LT) makes the fuel injection volume of the injector increase first and then decrease. The optimal VR solution for the LT is 0.0249 and the optimal ratio of the length to diameter of a pipeline solution is 55.10. The structure of the distribution tube and its matching to the common rail have little effect on the fuel flow characteristics. When the diameter and length of the injection tube are too large, the influence on the injection pressure of the injector is negatively correlated.
Labile silver(I) complexes with benzisothiazolinone anion and phosphines: Synthesis, characterization and hydrogen storage application
Authors: Alheety Mustafa A. , Aljibori Subhi A. , Nuaman Huda A. , Majeed Abdulwahhab H. , Singh Pramod K. , Shalu  , Yahya M. Z. A. 
Published: January 2024

AbstractA silver complex was prepared with benzisothiazolinone ligand, which was used to prepare new phosphorus‐rich complexes with dppe and dppp. All complexes were diagnosed by FTIR, 1H‐NMR, 31P‐NMR, CHN, and molar conductivity. The results proved that phosphines were labile, therefore 31P‐NMR was measured by cryoprotection at different temperatures. As a promoted effort to obtain direct experimental proof for the dimeric and the labile nature of [Ag(bit)(diphos)]2 complexes in solution, the 31P{1H}‐NMR spectrum of mixed (dppe/dppp) ligand complexes was measured. It was anticipated that an exchange of phosphines occurred between [Ag(bit)(dppe)]2 and [Ag(bit)(dppp)]2 complexes. However, a distribution of the dppp and dppe should result, and complex with compositions of [Ag2(bit)2(dppe)(dppp)] will be formed. The phosphine‐containing complexes were used in hydrogen storage study. The results proved that hydrogen storage values were initially similar for [Ag(bit)(dppp)]2 and [Ag(bit)(dppe)]2, but increased significantly for [Ag(bit)(dppe)]2 at higher pressures to reach 4.35 wt% at 90 bar.
Immunosuppressive therapy and COVID‐19 infection in patients with NMOSD
Authors: Choi Un Wai , Ai Xiwen , Li Hongyan , Hao Yong , Yao Xiaoying , Guan Yangtai 
Published: January 2024

AbstractIntroductionTo evaluate whether treated with immunosuppressants in neuromyelitis optica spectrum disorder (NMOSD) shows an effect on the severity and outcomes of COVID‐19 Omicron variant.MethodsThis is a substudy of a single‐center clinical trial involving human umbilical cord mesenchymal stem cells (hUC‐MSCs) in NMOSD patients. NMOSD patients with hUC‐MSCs treatment, NMOSD patients without hUC‐MSCs treatment, and matched healthy controls (HC) were included. Demographic information, NMOSD‐related clinical features, comorbidities, use of disease‐modifying therapy, COVID‐19 vaccination status, COVID‐19 clinical features, COVID‐19 clinical outcomes, and NMOSD‐related disease activity were obtained through online questionnaires or phone calls.ResultsThe majority of NMOSD patients received long‐term treatment with mycophenolate mofetil (68.8%) or azathioprine (22.9%), and 50% received oral glucocorticoid. During the epidemic, 97.4% of NMOSD patients infected with COVID‐19 had asymptomatic or mild forms, with only two patients (2.6%) requiring hospitalization. None of these patients required tracheal intubation or admission to the intensive care unit. Clinical symptoms were found to be more prevalent in HC groups. Additionally, the HC groups had higher fever‐recorded temperatures. NMOSD patients who received hUC‐MSCs treatment had shorter disease duration than patients who did not receive hUC‐MSCs treatment.DiscussionImmunosuppressant‐treated patients with NMOSD have a similar risk of COVID‐19 infection as the general population, but the disease duration is shorter and the clinical symptoms are less severe. Among our NMOSD patients who received hUC‐MSCs treatment, COVID‐19 outcomes were favorable, with no increased risk of severe COVID‐19. Prospective studies on immunotherapies are needed to help determine best treatment practices.
Evaluating the impact of climate change on irrigation canal performance
Authors: Mohebbi Hamideh , Ghodousi Hesam , Shahverdi Kazem 
Published: January 2024

AbstractIrrigation canals are the main systems that convey water from sources to demand nodes. Their performance is affected by climate change. In this research, the effect of climate change on temperature and precipitation was investigated in the Aghili irrigation network over the base period 1994–2017, and the Aghili east canal performance was consequently assessed. To this end, the climate data were first assessed by the Mann–Kendall test to determine trends. Then, changes in temperature and precipitation were simulated using HadGEM2‐ES in the Long Ashton Research Station Weather Generator (LARS‐WG) under two representative concentration pathways (RCPs) of 2.6 and 8.5 over the periods 2021–2040 and 2041–2060. CROPWAT8 was used to calculate the crop water requirement and irrigation hydromodule, and the turnout flow in the considered canal was calculated next. Finally, the canal was simulated and assessed. The results showed that the maximum temperature, evapotranspiration and turnout flow increases are 3.7°C, 1.45 mm/day and 39 L/s, respectively, related to the base timescale. Additionally, the adequacy performance decreased to 0.768 from 0.986, leading to a maximum extra water requirement of 15.1 million m3/year in the Aghili east canal under a pessimistic scenario.
Sensory acceptability and nutritional quality of composite bread with added puree from biofortified beans in Malawi
Authors: Kasapila William , Mwangwela Agnes Mbachi , Njera Dumbo , Matumba Limbikani , Ng'ong'ola Manani Tinna , Banda Richard , Nyirenda Lackson 
Published: January 2024

AbstractOf late, the global supply of wheat is increasingly becoming lower and lower due to the continuing Russia–Ukraine war, blockages of major seaports as a result of the war and climate change. Importing countries are hardest hit as prices skyrocket. Millions of people relying on bread as staple food are affected in multiple ways. New methods to prepare composite bread that meets sensory and nutritional needs of consumers are needed to help address the problem. This study modified the standard recipe and developed bread with 20%, 30% and 50% of the wheat flour substituted by puree from NUA 45 biofortified beans. Ascorbic acid was added to improve the functionality of the yeast and the quality of the bread. Testers rated the 20% bean puree bread as the most acceptable. The appearance, flavour and taste imparted by the bean puree and lemon juice were the major sensory attributes for acceptance, accounting for over 65.79% of the variance in the principal component analysis. Although the test bread was slightly denser than the traditional one with 100% wheat flour, the bean puree enhanced the nutritional quality with average proximate values of protein found to be 1.66 ± 0.18, fat 7.42 ± 0.36, carbohydrates 57.19 ± 0.27, iron 2.04 ± 0.03 and zinc 2.25 ± 0.02 per 100 g of sample. The study concludes that puree from beans can be used to replace 20%–30% of wheat flour in bread making. The bread can be an option for people interested in variety, heavier meals and nutrition.
Temperature and hypoxia‐driven shifts in Daphnia interspecific competition
Authors: Maszczyk Piotr , Krajewski Karol , Leniowski Konrad , Pukos Szymon , Wawrzeńczak Julia , Wilczynski Wojciech , Zebrowski Marcin Lukasz , Lee Jae‐Seong , Babkiewicz Ewa 
Published: January 2024

AbstractPrevious research has shown that elevated temperature and environmental hypoxia are associated with a reduced representation of larger‐bodied species in communities of ectotherms, suggesting their competitive disadvantage resulting from increased oxygen demands and limited oxygen availability. To investigate this, we conducted a comparative analysis of two pairs of competing zooplankton species: Daphnia galeata (smaller‐bodied) and Daphnia pulex (larger‐bodied), as well as D. pulex (smaller‐bodied) and Daphnia magna (larger‐bodied). We monitored their population dynamics under different oxygen concentrations and temperatures, and additionally measured hemoglobin concentration in the latter pair. Contrary to expectations, the results demonstrated that the larger‐bodied species outcompeted the smaller‐bodied ones in all experimental treatments involving the first pair of species. In the second pair, elevated temperature favored the smaller‐bodied species, while environmental hypoxia had the opposite effect. The competitive advantage of D. pulex under elevated temperature likely stemmed from their ability to allocate energy from somatic growth to reproduction, as indicated by the increased number of reproducing females. Conversely, the competitive advantage of D. magna under environmental hypoxia may be attributed to their ability to reallocate energy from reproduction to somatic growth, as indicated by lower reproductive effort and greater plasticity in hemoglobin production. These findings indicate that elevated temperature and hypoxia can independently and jointly influence interspecific competitive abilities by impacting the pace of life. However, the numerical dominance of smaller‐sized species in warm and hypoxic zooplankton communities cannot be explained by their enhanced competitive abilities resulting from a more favorable oxygen supply demand balance.
Herpes Zoster and Risk of Incident Parkinson's Disease in US Veterans: A Matched Cohort Study
Authors: Tunnicliffe Louis , Weil Rimona S. , Breuer Judith , Rodriguez‐Barradas Maria C. , Smeeth Liam , Rentsch Christopher T. , Warren‐Gash Charlotte 
Published: January 2024

AbstractBackgroundAlthough some systemic infections are associated with Parkinson's disease (PD), the relationship between herpes zoster (HZ) and PD is unclear.ObjectiveThe objective is to investigate whether HZ is associated with incident PD risk in a matched cohort study using data from the US Department of Veterans Affairs.MethodsWe compared the risk of PD between individuals with incident HZ matched to up to five individuals without a history of HZ using Cox proportional hazards regression. In sensitivity analyses, we excluded early outcomes.ResultsAmong 198,099 individuals with HZ and 976,660 matched individuals without HZ (median age 67.0 years (interquartile range [IQR 61.4–75.7]); 94% male; median follow‐up 4.2 years [IQR 1.9–6.6]), HZ was not associated with an increased risk of incident PD overall (adjusted HR 0.95, 95% CI 0.90–1.01) or in any sensitivity analyses.ConclusionWe found no evidence that HZ was associated with increased risk of incident PD in this cohort. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Profiles of Intestinal Flora in Breastfed Obese Children and Selecting Functional Strains Against Obesity
Authors: Liang Cong , Niu Hai‐Yue , Lyu Lin‐Zheng , Wu Yi‐Fan , Zhang Lan‐Wei 
Published: January 2024

ScopeBreast milk has the potential to prevent childhood obesity by providing probiotics, but there are still instances of obesity in breastfed children.Methods and ResultsThis study investigates the difference in intestinal flora structure between breastfed children with obesity (OB‐BF) and normal‐weight breastfed children (N‐BF). Building upon this foundation, it employs both cell and mouse models to identify an antiobesity strain within the fecal matter of N‐BF children and explore its underlying mechanisms. The results reveal a reduction in lactobacillus levels within the intestinal flora of OB‐BF children compared to N‐BF children. Consequently, Lactobacillus plantarum H‐72 (H‐72) is identified as a promising candidate due to its capacity to stimulate glucagon‐like peptide‐1 (GLP‐1) secretion in enteroendocrine cells (ECCs). In vivo, H‐72 effectively increases serum GLP‐1 concentration, reduces food intake, regulates the expression of genes related to energy metabolism (SCD‐1, FAS, UCP‐1, and UCP‐3), and regulates gut microbiota structure in mice. Moreover, the lipoteichoic acid of H‐72 activates toll‐like receptor 4 to enhanced GLP‐1 secretion in STC‐1 cells.ConclusionsL. plantarum H‐72 is screened out for its potential antiobesity effect, which presents a potential and promising avenue for future interventions aimed at preventing pediatric obesity in breastfed children.
Planar antenna array synthesis for wireless power transmission based on brain storm optimization algorithm
Authors: Zhang Qing He , Shan Yan , Shen Zhao Yang , Liu Guang Xu 
Published: January 2024

AbstractThis study investigates the synthesis of a two‐dimensional transmitting planar antenna array for a wireless power transmission system. The antenna synthesis problem is transformed into an optimization problem under multiple constraints. Accordingly, a brainstorming optimization algorithm is utilized to optimize the element position of the planar antenna arrays under the constraints of aperture size, array spacing, and side lobe level. A numerical simulation of the beam collection efficiency is conducted under different receiving region shapes. The simulation results confirm the effectiveness of the proposed method in optimizing the two‐dimensional transmitting planar antenna array for wireless power transmission systems.