bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nosocomial Urinary Tract Infections in a Tertiary Hospital; Preliminary
Study of Antibiotics Susceptibility Testing and Pathogen Types
Authors: Tolou-Ghamari Zahra 
Published: October 2023

Introduction:
Nosocomial urinary tract infections (NUTIs) are the most frequently
acquired infection worldwide. This retrospective study aimed to determine the type of pathogens
and antibiotic susceptibility testing in hospital-acquired UTIs.

Methods:
Information from the recorded official database of the Alzahra, Isfahan/Iran tertiary
specialist hospital was obtained. Urine was collected based on two methods: 1) central stream
and 2) with a urinary catheter in place. The incidence of acquired infections (NUTIs-SUTI; Code
55) was described as a percentage. The statistical calculations were conducted using the statistical software. There were 2210 recorded NUTIs comprised of 1115 males and 1095 females.
Among the total recorded data with NUTIs, 251 records were associated with deaths. The distribution of hospital stays in 57% was between 2-30 days. Available data showed that Candida
(23%), Escherichia coli (22%), Klebsiella pneumonia (17%), and Enterococcus (faeciumfecalis; 12%) were the most ranked microorganisms in patients with NUTIs.

Resulsts:
Sensitivity tests for Escherichia coli associated with different antibiotics were ranked
as; 1) Meropenem (n= 160; S= 66%), 2) Vancomycin (n= 53; S= 64%), 3) Piperacillin/Tazobactam (n= 144; S= 58%), 4) Amikacin (n= 146; S= 44%), 5) Co-trimoxazole (n= 153; S=42%),
6) Penicillin (n=79; S=41%), 7) Cefepime (n=143; S=31%), 8) Ceftazidime (n=142; S=31%),
9) Ciprofloxacin (n=204; S=25%). Sensitivity tests for Klebsiella pneumonia associated with
different antibiotics were ranked as; 1) Piperacillin/Tazobactam (n= 110; S= 55%), 2) Amikacin
(n= 125; S= 55%), and 3) Ciprofloxacin (n=177; S=23%). Sensitivity tests for Enterococcus
(faecium-fecalis) associated with different antibiotics were ranked as; 1) Piperacillin/Tazobactam (n= 79; S= 62%), 2) Amikacin (n= 83; S= 64%) and 3) Ciprofloxacin (n=120; S=30%).

Conclusion:
Within the population studied, while Ciprofloxacin showed less than 30% sensitivity, Piperacillin/Tazobactam and Amikacin exhibited a sensitivity of more than 50% regarding
Escherichia coli, Klebsiella pneumonia, and Enterococcus (faecium-fecalis) need further evidence-based investigations
In vitro Regeneration of Multiple Shoots in Abelmoschus esculentus (L.) Moench (Okra) via Apical Shoot Meristem Culture
Authors: Daniel Melvin A. , Packiam S. Maria , Veeramuthu Duraipandiyan 
Published: October 2023

Introduction:
To develop the efficient protocol for multiple shoot regeneration of A.esculentus by apical root culture method. Abelmoschus esculentus L., commonly known as okra, is a member of the Malvaceae family, which is widely consumed due to its high nutrient content and potential therapeutic properties. Okra contains various bioactive compounds that ex-hibit antibacterial properties and may be useful in treating type-2 diabetes, digestive diseases, and liver detoxification. To select the plant for the present and prepare the efficient protocol for the development of multiple shoot regeneration culture method.

Methods:
In this study, we developed an efficient protocol for multiple shoot regeneration of A. esculentus using the apical shoot culture method. Mature shoot apex explants of the germinated A. esculentus genotype CoBhH1 were cultured on Murashige and Skoog (MS) medium supple-mented with different concentrations of cytokinins (BAP and TDZ) and auxins (IAA and NAA) to determine the optimal conditions for shoot induction.

Results:
The highest number of multiple shoots (27.04 shoots) was obtained with 0.8 mg/L TDZ. Excised shoots were cultured on MS medium supplemented with GA3, which induced elongation of the shoots to a maximum of 8-10 cm. Regenerated plantlets were successfully transferred to soil, with a 100% survival rate and no differences in morphology or growth characteristics com-pared to control plants. Rooting was achieved with 1 mg/L IBA.

Conclusion:
This study provides an efficient protocol for multiple shoot regeneration of A. esculentus through apical shoot culture, which has potential applications in plant breeding and genetic engineering.
O folclorismo e a melodia na 1.ª Suite Alentejana (1919) de Luís de Freitas Branco
Authors: Matos Vitor , Maia Pedro , Fonte Vera 
Published: October 2023

Obra distinta e particular na produção de Luiz de Freitas Branco (1890–1955), a 1.ª Suite Alentejana (1919) apresenta-se conotada com uma vertente menos usual da linguagem do compositor – a evocação de elementos folclorizantes da sua região de eleição, o Alentejo. Praticamente um aparte na sua criação musical, a Suite espelha assim uma versatilidade na sua dimensão estética, revelando concomitantemente um lado tão universalista como racional – alguém que se socorre dos meios necessários para atingir um determinado fim. Apesar de vários autores reconhecerem a vertente folclorista na 1.ª Suite Alentejana, este aspeto ainda está por explorar de forma mais aprofundada, partindo de um estudo mais detalhado da escrita musical adotada por Freitas Branco. Com este artigo pretendemos propor uma análise da partitura focada nos diferentes tipos de melodias e texturas utilizadas, de forma a identificar e compreender melhor de que modo o autor incorpora elementos de cariz folclórico no discurso musical da obra.
Education of Patients With Atrial Fibrillation and Evaluation of the Efficacy of a Mobile Virtual Patient Environment: Protocol for a Multicenter Pseudorandomized Controlled Trial
Authors: Antoniou Panagiotis , Dafli Eleni , Giannakoulas George , Igimbayeva Gaukhar , Visternichan Olga , Kyselov Serhii , Lykhasenko Ivetta , Lashkul Dmytro , Nadareishvili Ilia , Tabagari Sergo , Bamidis Panagiotis D 
Published: October 2023

Background
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a leading cause of mortality and morbidity. Patient knowledge about AF and its management is paramount but often limited. Patients need to be appropriately informed about treatment options, medicinal adherence, and potential consequences of nonadherence, while also understanding treatment goals and expectations from it. Mobile health apps have experienced an explosion both in their availability and acceptance as “soft interventions” for patient engagement and education; however, the prolific nature of such solutions revealed a gap in the evidence base regarding their efficacy and impact. Virtual patients (VPs), interactive computer simulations, have been used as learning activities in modern health care education. VPs demonstrably improved cognitive and behavioral skills; hence, they have been effectively implemented across undergraduate and postgraduate curricula. However, their application in patient education has been rather limited so far.

Objective
This work aims to implement and evaluate the efficacy of a mobile-deployed VP regimen for the education and engagement of patients with AF on crucial topics regarding their condition. A mobile VP app is being developed with the goal of each VP being a simple scenario with a set goal and very specific messages and will be subsequently attempted and evaluated.

Methods
A mobile VP player app is being developed so as to be used for the design of 3 educational scenarios for AF management. A pseudorandomized controlled trial for the efficacy of VPs is planned to be executed at 3 sites in Greece, Ukraine, and Kazakhstan for patients with AF. The Welch t test will be used to demonstrate the performance of patients’ evaluation of the VP experience.

Results
Our study is at the development stage. A preliminary study regarding the system’s development and feasibility was initiated in December 2022. The results of our study are expected to be available in 2024 or when the needed sample size is achieved.

Conclusions
This study aims to evaluate and demonstrate the first significant evidence for the value of VP resources in outreach and training endeavors for empowering and patients with AF and fostering healthy habits among them.

International Registered Report Identifier (IRRID)
PRR1-10.2196/45946
Potential Schizophrenia Disease-Related Genes Prediction Using Metagraph Representations Based on a Protein-Protein Interaction Keyword Network: Framework Development and Validation
Authors: Yu Shirui , Wang Ziyang , Nan Jiale , Li Aihua , Yang Xuemei , Tang Xiaoli 
Published: October 2023

Background
Schizophrenia is a serious mental disease. With increased research funding for this disease, schizophrenia has become one of the key areas of focus in the medical field. Searching for associations between diseases and genes is an effective approach to study complex diseases, which may enhance research on schizophrenia pathology and lead to the identification of new treatment targets.

Objective
The aim of this study was to identify potential schizophrenia risk genes by employing machine learning methods to extract topological characteristics of proteins and their functional roles in a protein-protein interaction (PPI)-keywords (PPIK) network and understand the complex disease–causing property. Consequently, a PPIK-based metagraph representation approach is proposed.

Methods
To enrich the PPI network, we integrated keywords describing protein properties and constructed a PPIK network. We extracted features that describe the topology of this network through metagraphs. We further transformed these metagraphs into vectors and represented proteins with a series of vectors. We then trained and optimized our model using random forest (RF), extreme gradient boosting, light gradient boosting machine, and logistic regression models.

Results
Comprehensive experiments demonstrated the good performance of our proposed method with an area under the receiver operating characteristic curve (AUC) value between 0.72 and 0.76. Our model also outperformed baseline methods for overall disease protein prediction, including the random walk with restart, average commute time, and Katz models. Compared with the PPI network constructed from the baseline models, complementation of keywords in the PPIK network improved the performance (AUC) by 0.08 on average, and the metagraph-based method improved the AUC by 0.30 on average compared with that of the baseline methods. According to the comprehensive performance of the four models, RF was selected as the best model for disease protein prediction, with precision, recall, F1-score, and AUC values of 0.76, 0.73, 0.72, and 0.76, respectively. We transformed these proteins to their encoding gene IDs and identified the top 20 genes as the most probable schizophrenia-risk genes, including the EYA3, CNTN4, HSPA8, LRRK2, and AFP genes. We further validated these outcomes against metagraph features and evidence from the literature, performed a features analysis, and exploited evidence from the literature to interpret the correlation between the predicted genes and diseases.

Conclusions
The metagraph representation based on the PPIK network framework was found to be effective for potential schizophrenia risk genes identification. The results are quite reliable as evidence can be found in the literature to support our prediction. Our approach can provide more biological insights into the pathogenesis of schizophrenia.
Reconstrução do Estado e do seu papel
Authors: Gurgel Claudio 
Published: October 2023

As expectativas em relação ao novo governo federal, predominantemente constituído por desenvolvimentistas, incluem o retorno do protagonismo do Estado e da administração pública. Espera-se uma intensa movimentação dos órgãos e entes públicos nos próximos anos, com muitas razões e motivações. É absolutamente compreensível que isso aconteça, seja por conta dos governos anteriores do atual presidente, seja pela evidente necessidade de reconstrução de parte do aparelho do Estado muito combalido.
Isso quase que por extensão se expressa nas reflexões, debates, pesquisas e produções acadêmicas de variada natureza, nos últimos meses. Por isso, as revistas acadêmicas têm recebido trabalhos que abordam o Estado e a administração pública com muita frequência e na EAS não foi diferente. Não por uma deliberação, mas pela força desse ambiente, o número atual da EAS está voltado essencialmente para questões relacionadas com a administração pública brasileira.
General social principles of administrative activity of the Judicial Protection Service of Ukraine
Authors: Chumak V. 
Published: October 2023

The article defines general social principles of activity of the Judicial Protection Service of Ukraine. It is noted that the following principles are proposed to be included in the system of general social principles of the administrative activity of the Judicial Protection Service of Ukraine: democracy; transparency; humanity; public trust; external interaction; controllability and accountability; a combination of persuasion and coercion.
It is emphasized that the principle of humanity means that an employee of the Judicial Protection Service of Ukraine must be polite, kind and delicate in relation to suspects, witnesses or victims in their activities. Inhumane or humiliating treatment of anyone, regardless of their status, during legal relations with the Judicial Protection Service of Ukraine is unacceptable.
It is emphasized that conviction in the administrative activity of the Judicial Protection Service of Ukraine is a method of influencing people’s consciousness and behavior, which is a set of educational, explanatory and encouraging measures, carried out with the aim of increasing legal awareness of citizens and voluntary compliance and enforcement of laws.
It is noted that the principle of combining persuasion and coercion in the administrative activity of the Judicial Protection Service of Ukraine is quite important. Without the use of persuasion and coercion, the Judicial Protection Service of Ukraine would not be able to function properly and properly perform the functions delegated by the state when performing administrative activities.
By general social principles, we propose to understand the principles on which the relations of the Judicial Protection Service of Ukraine with society should be based. In our opinion, the operation of the Judicial Protection Service of Ukraine in compliance with these principles will allow us to satisfy the public’s desire to improve the entire Judicial Protection Service of Ukraine in general.
Problem issues of criminal liability for illegal cutting
Authors: Chechersky V. 
Published: October 2023

In the context of the armed aggression against Ukraine, the issue of environmental protection becomes particularly acute.
The World Meteorological Organization has said that recent years have been the warmest on record. Over the past 50 years, there have been five times as many weather-related, climate-related, and water-related catastrophes.
Forests play an important role in combating climate change and preserving human-friendly living conditions on Earth. Therefore, the task of preserving and increasing forest cover acquires not only national, but also international strategic importance.
The article examines the issue of improving legal mechanisms for the protection and protection of forests, in particular the provisions of the Criminal Code. It is noted that the current version of Article 246 of the Criminal Code of Ukraine is not consistent with other norms that regulate legal relations in this area. First of all, this is related to the change in the definition of “forest” and “forest fund” contained in the Forest Code of Ukraine.
Additionally, the application of Article 246 of the Ukrainian Criminal Code reveals serious flaws in its design as well as a failure to adhere to contemporary environmental protection standards and regulations.
One of the consequences of this shortcoming is that in practice it is almost impossible to prosecute for the transportation or storage of illegally cut wood, since it is necessary to prove the fact of illegal cutting.
The article substantiates the need to expand the range of actions for which criminal liability should arise under this article. In particular, it is proven that criminal liability for illegal cutting of trees and shrubs should not be limited to forests, protective and other forest plantations.
Taking into account the social importance, it is proposed to establish responsibility under the third part of this article also for the felling of trees and shrubs in parks and squares, as special objects of urban improvement.
Also given are the reasons for the need to separate an additional article in the Criminal Code of responsibility for transportation, storage, sale of illegally cut trees and shrubs, as well as wood. Relevant legislative changes are proposed.
Forensic support of court proceedings: ontological, methodological and praxeological aspects
Authors: Myroshnychenko Yu. 
Published: October 2023

The article presents the results of comprehension by the author of the phenomenon of forensic support as a separate entity, the system in which the processes of production, dissemination and application of forensic knowledge in practice take place. Accordingly, in the ontological aspect, forensic support is seen as a complex, multifaceted system that includes a number of subsystems functionally interconnected by the general purpose, the main among which are the science of forensic science, forensic education and forensic practice. Each of them has its own components, which can also be considered and described as systems consisting of certain elements – individual processes and their results, which have their own structure, including objects, subjects, connections, functions and goals.
Forensic support of law enforcement and judicial activities, considered under the system-activity (process) point of view can be represented as a system of scientific, pedagogical and applied activities for the development of forensic techniques, methods and recommendations, the transfer of knowledge about them to the subjects of these types of activities, the formation of their skills and abilities necessary for the effective use of forensic tools in each forensic situation in order to positively implement their professional tasks and procedural functions. From the standpoint of the resource approach, forensic support is a set of forensic technical means, tactical techniques and methodological recommendations, as well as forensic knowledge and skills of subjects authorized to disclose, investigate and litigate criminal cases.
The practical component of the forensic support of the trial of criminal cases is the activity of the court in the formation and further application of the complex, developed by the national forensic science and tested by judicial practice of measures aimed at reducing the influence of the factor of information uncertainty of the initial stage of the trial, forecasting.
Budgetary process development at the local level: foreign expertise
Authors: Diedushev I. 
Published: October 2023

This paper highlights the foreign expertise of the budgetary process development at the local level. It states that the armed aggression of the Russian Federation resulted in significant damage to the economy of Ukraine, affecting thus the development of the budgetary process. Modern scholars studying the domestic budgetary process, including its local dimension, are listed.
The aim of the research is to perform a critical review of the foreign experience regarding the budgetary process development at local level.
This paper highlights the concept of the budgetary process in Ukraine, the essentials of its five stages, the reasons for the low quality of the budgetary process in Ukraine, the core principles being followed in the European Union states in the process of securing selected tax revenues for local self-government bodies, essential factors determining the possibility to assign certain taxes within the local category, the main characteristics of the local budgets’ revenue share establishment in developed Western countries, distinguishing these from domestic practice. It is emphasized that for all developed foreign states division of local budgets into local operational (administrative) budget and local development budget (investment budget) is typical. It is stressed that the main focus of budgetary policy in the countries of Central and Eastern Europe was placed on decreasing the amount of transfers and taking parallel measures to raise the share of tax revenues, ensuring the establishment of self-sufficient and financially capable territorial communities. Аuthor paid special attention to research of budgetary process specificity in Germany, United Kingdom and France.
The conclusions contain a statement for the budgetary process of any country to be characterized by certain features reflecting the specificity of national economy regulation, the structure of domestic production and means of influencing the development of the financial system. Modern global trends are characterized by the increasing importance of decentralization in the organization of local financial systems and changes in budgetary processes at the local level.
Politeness Strategies in Classroom Interaction between Teacher and Students and among Students at Senior High School
Authors: Ginting Kristiani Lisma Vera Br , Pasaribu Arsen Nahum 
Published: October 2023

In classroom, politeness is needed to be applied to build a good relationship, good social interaction, and comfortable communication between teacher and students and avoid conflict which possibly happens. The purpose of this research is to know the types of politeness strategies used by students and teachers in classroom interaction and to describe the politeness strategies are realized in the teacher – student’s classroom interaction. This research are expected to be valuable for the teacher as the model in English teaching, the teacher can teach moral education in the teaching and learning process. Students will aware of the importance of politeness in English teaching and learning. The people who use polite language will be more honored and accepted in community. Polite in communication make conversation get closer between sepaker and hearer. There are four types of polieness strategies, there are Blad On Record, Positive Politeness Strategies, Negative Politeness Strategies and Off Recordthe researcher found the dominant strategy in teacher-students communication was Bald On Record Strategy which has 13 frequency (44,82%), and followed by Positive which has 10 fruquency (34,48%)In communication among students, the researcher found the most dominant politeness strategy used among students is positive politeness which has 21 frequency (46,66%) and followed by bald on record 17 frequency (37,77%).