bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suvi Salmenniemi, Affect, Alienation and Politics in Theraupetic Culture: Capitalism on the skin
Authors: Poutanen Mikko J. 
Published: November 2023

Kirja-arvio: Suvi Salmenniemi, Affect, Alienation and Politics in Theraupetic Culture: Capitalism on the skin. Lontoo: Palgrave Macmillan, 2022, 222 s.
Sosiologinen etnografia avaa mielenkiintoisella ja merkittävällä tavalla "terapiakulttuurin" käsitettä, johon nivoutuu myös osaksi keskustelu vieraantumisen käsitteestä ja kokemuksesta.
El Aprendizaje de Números Fraccionarios Mediado por una Aplicación de Videojuego en Estudiantes de Grado Séptimo
Authors: Aragón Villanueva Hoover Orlando 
Published: November 2023

En el marco de los denominados Recursos Educativos Digitales, se da a conocer este estudio cuyo objetivo fue analizar el aprendizaje de números fraccionarios antes y después de un tratamiento, mediado por una aplicación de video juego en estudiantes de grado séptimo de la Institución Educativa José Aquilino Durán, de Cúcuta, Norte de Santander. El soporte teórico estuvo sustentado en la teoría del Conectivismo. La metodología se sustentó en un tipo de investigación cuantitativo con un diseño cuasiexperimental de pretest y postest con un solo grupo. El pretest reflejó deficiencias en todos los temas sobre números fraccionarios evaluados. Ello llevó a proponer un plan de tratamiento sobre el aprendizaje de los números fraccionarios con la utilización de videojuegos denominados Fracciretos y creado por el investigador. La implementación fue positiva pues, la aplicación del postest, luego del desarrollo de las actividades con Fracciretos, reflejó resultados significativos. Las conclusiones permiten reflexionar que los videojuegos utilizados permiten mayor participación de los estudiantes en las actividades desarrolladas, por lo cual este tipo de Recursos Digitales se constituyen en herramientas útiles en los procesos de enseñanza y aprendizaje de los números fraccionarios.
Genome-Wide Analysis of the Ethylene-Insensitive3-Like Gene Family in Cucumber (Cucumis sativus)
Authors: Mushtaq Rabia , Khan Muziyen , Manzoor Mujahid , Shafiq Muhammad , Bilal Muhammad , Manzoor Tariq , Ali Muhammad , Mazhar Hafiz Sabah-Ud-Din , Hashmi Muneeb , Anees Muazzam , Rizwan Muhammad , Haider Muhammad Saleem 
Published: November 2023

The ethylene hormone identification process, which regulates the overall rate of fruit development and formation is heavily dependent on the ethylene-insensitive 3/Ethylene-insensitive3-like (EIN3/EIL) protein family. EIL harmone improve the plant's defense against both biotic and abiotic stresses. Research of the EIL family has been done for many plant species but in cucumber, this Gene family has not been investigated yet. Mining of the cucumber genome has identified four member of the EIL gene family using various bioinformatics tool. EIL proteins in cucumbers clustered into 4 subgroups (groups 1,2,3,4) based on the established cucumber classification. Sequence analysis and phylogeny research showed that CsEIL3 and other EIN3/EIL plant proteins isolated from a progenitor signal at the time of emergence have a high degree of similarity; CsEIN3 is involved in the flower growth process. Comprehensive genome evaluation of the EIL gene family in cucumber provides the ability to analyze and analyze the performance of this gene family.
Le mémorial des frères Léonard à Gouvy
Authors: Zelis Guy 
Published: November 2023

À Gouvy, en province de Luxembourg, en Belgique, à proximité de la frontière grand-ducale, à l’orée d’un petit bois de sapins, un humble mémorial est dédié aux quatre frères Léonard, exécutés par l’occupant allemand le 6 janvier 1945.
Oppenheimer: tussen doem en glorie
Authors: Capiau Brecht 
Published: November 2023

Water. Het is een van de vier natuurelementen die het leven op onze aarde mogelijk maakt. De regendruppels in het openingsshot van de nieuwste film van de Brits-Amerikaanse regisseur Christopher Nolan zijn voor J. Robert Oppenheimer echter meer dan dat. Het zijn ook twee waterstofatomen die gekoppeld zijn aan een zuurstofatoom. Hoe gedragen atomen zich tegenover elkaar en welke veranderingen ondergaan ze? Het is een bron van fascinatie, maar ook van menig paniekaanval voor de student Oppenheimer omdat hij de implicaties van zijn theorieën nog niet ten volle beseft. Dit voortschrijdende inzicht zorgt ervoor dat de Amerikaan de moderne quantummechanica, een wetenschappelijke discipline die in de Verenigde Staten nog in zijn kinderschoenen staat, leert kennen om ze vervolgens volledig te omarmen.
Scientific Articulation during Collaborative Digital Game-Based Learning Enhances Learning of Immunology
Authors: Low Pey-Yng , Lim Gaik-Bee 
Published: November 2023

Abstract
Digital game-based learning has been used to help learners grasp complex concepts in science subjects such as immunology. The aim of this study was to examine whether playing a digital game collaboratively would encourage articulation of scientific terminology and concepts, and whether this would result in learning gains. Forty-seven students at a tertiary institution (17–19 y of age) played a game (n = 22) or watched a video of the game (n = 25) in small groups. This was followed by an activity to document the key learning points. Pretest and posttest results showed that although both groups had learning gains, the game-based learning group outperformed the video group for gains in procedural knowledge, suggesting that playing the game helped students to better internalize the steps involved in the immune response. For the game-based learning group, there was a positive correlation between the number of scientific terms articulated and the gains in the test scores. However, for the video group, there was no correlation. The implications for designing digital game-based learning activities for learning are discussed. The study was carried out in an online environment due to the COVID-19 pandemic mandating home-based learning at the time. The discussion also focuses on how the findings can be applied in an online and face-to-face context.
Machine Learning Models for Predicting the Type and Outcome of Ureteral Stones Treatments
Authors: Rashidi Elahe , Langarizadeh Mostafa , Sayadi Mohammadjavad , Sarkarian Mohsen 
Published: November 2023

AbstractBackground:Kidney and ureter stones are the third pathologies in urological diseases. Less invasive treatments such as transureteral lithotripsy and extracorporeal shock wave lithotripsy are used to treat ureteral stones. Data mining has provided the possibility of improving decision-making in choosing the optimal treatment. In this paper predictive models for the detection of ureter stone treatment (first model) and its outcome (second model) is developed based on the patient’s demographic, clinical, and laboratory factors.Methods and Material:In this cross-sectional study a questionnaire was used to identify the most effective features in the predictive models, and Information on 440 patients was collected. The models were constructed using machine learning techniques (Multilayer perceptron, Classification, and regression tree, k-nearest neighbors, Support vector machine, Naïve Bayes classifier, Random Forest, and AdaBoost) in the Bigpro1 analytical system.Results:Among the Holdout and K-fold cross-validation methods used, the Holdout method showed better performance. From the data-based balancing methods used in the second model, the Synthetic Minority oversampling technique showed better performance. Also, the AdaBoost algorithm had the best performance. In this algorithm, accuracy, sensitivity, specificity, precision, F- measure, and Area under the carve in the first model were 89%, 87%, 91%, 90%, 89%, and 94% respectively, and in the second model were 81%, 81%, 82%, 84%, 82%, and 85% respectively.Conclusions:The results were promising and showed that the data mining techniques could be a powerful assistant for urologists to predict a surgical outcome and also to choose an appropriate surgical treatment for removing ureter stones.
Complex Bilateral Posterior Hip Dislocation with a Long-term Follow-up—A Case Report
Authors: Kheiri Sara , Andalib Ali , Piri Ardakani Mohammadreza 
Published: November 2023

Abstract
Bilateral hip dislocations are among the rarest traumatic incidents. We report a case of a 45-year-old, opium-addicted man with bilateral posterior hip dislocation and bilateral femoral head fractures proximal to the fovea with more comminution on the left side. After an unsuccessful closed reduction attempt, surgical reduction and internal fixation of the left and right femoral heads were performed on admission and 72 hours later. He was readmitted because of acute deep vein thrombosis (DVT) on the left side after six weeks and left femoral head avascular necrosis (AVN) after 14 months. All complications occurred on the left side regardless of the sooner intervention in this side compared with the right side. This may imply that the severity of the initial trauma could be a more important risk factor for AVN rather than other factors in case the reduction is delayed for more than six hours.
Analysis of Tuberculosis-related Mortality during the First Wave of the COVID Pandemic at GHTM, Tambaram Sanatorium
Authors: Sridhar R. , Viswanathan Vinod Kumar , Singh Reetu , Keyzare Rafeeqa 
Published: November 2023

Introduction:
Analysis of tuberculosis (TB) mortality serves to understand the impact of health delivery services and steps needed to eliminate the global burden of TB. With the advent of the COVID pandemic in 2020, there were challenges in delivery of TB services, and this study was undertaken to understand the impact of pandemic on TB mortality.

Methodology:
Retrospective analysis of death records of patients died due to TB in the year 2020 was done.

Results:
The data of 250 patients who died due to TB in GHTM in 2020 were analyzed. Most were males in the productive age group of 20 to 60 years. Sputum positivity, male gender, drug resistance, and presence of comorbidities such as DM and HIV contributed to most of the mortality. A drop in presumptive TB cases and notification of TB cases compared to the previous years was noted.

Discussion:
The demographic profile of patients and risk factors for TB mortality in this study was consistent with known risk factors such as male, sputum positive status, drug resistance, and comorbidities. Drop in notification of TB cases due to the pandemic was noted, and necessary steps for tracing and diagnosing these cases will help reduce mortality due to impact of the pandemic. Analysis of mortality data also reflects on the need for early diagnosis and the use of appropriate treatment protocols and need for new drugs to eliminate and reduce TB mortality.

Conclusion:
This study emphasises on the need for ensuring continued diagnosis and uninterrupted treatment of TB even in pandemic situations to make the goal of TB elimination a reality.
Maxillary Mucormycotic Osteonecrosis as a Manifestation of Post-COVID-19 Infection in Non-diabetic Patients: Report of Two Cases
Authors: Paavai Thamizhanambi Tamizh , Vasanthi V. , Rameshkumar Annasamy , Rajkumar Krishnan , Krishnakumar Raja V. B , Muthusubramanian Veerabahu 
Published: November 2023

Abstract
Mucormycosis is a rare, opportunistic fungal infection prevalent in the elderly, especially in patients with uncontrolled diabetes or a compromised immune system. However, the outbreak of the pandemic declared by the World Health Organization in late 2019 increased the incidence of mucormycosis cases in COVID-19 patients due to increased steroid usage that resulted in an immunocompromised state. The current report presents two cases of oral mucormycotic osteomyelitis in patients who developed diabetes post-COVID infection, along with a review and relevant literature.
DETERMINAN PENERIMAAN RETRIBUSI PARKIR DI KABUPATEN KETAPANG PROVINSI KALIMANTAN BARAT
Authors: Elpiani Elpiani , Restiatun Restiatun , Yani Akhmad 
Published: November 2023

Retribusi parkir merupakan salah satu sumber potensial bagi Pendapatan Asli Daerah (PAD). Pada tahun 2021, Kabupaten Ketapang merupakan kabupaten dengan tingkat PAD tertinggi dan kabupaten dengan penerimaan retribusi parkir tertinggi di Provinsi Kalimantan Barat. Penerimaan dari retribusi parkir merupakan sumber Pendapatan Asli Daerah yang potensial, mengingat adanya fakta terjadinya peningkatan jumlah kendaraan bermotor di Kabupaten Ketapang, baik mobil maupun sepeda motor. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi penerimaan retribusi parkir di Kabupaten Ketapang, Provinsi Kalimantan Barat. Variabel terikat dalam penelitian ini adalah penerimaan retribusi parkir, sedangkan variabel bebasnya adalah jumlah mobil (car), jumlah motor (bike), jumlah petugas parkir (park) dan jumlah hari hujan dalam sebulan (rain). Data yang digunakan dalam penelitian ini adalah data time series yang diperoleh dari publikasi resmi Badan Pusat Statistik Kabupaten Ketapang, BMKG Kabupaten Ketapang dan Dinas Perhubungan Kabupaten Ketapang. Data yang digunakan dalam penelitian ini berupa data bulanan sepanjang tahun 2019 – 2021. Adapun model yang digunakan dalam penelitian ini adalah Model Ordinary Least Square (OLS). Temuan dari penelitian ini adalah variabel jumlah petugas parkir berpengaruh positif signifikan terhadap penerimaan retribusi, sedangkan variabel jumlah mobil, jumlah motor, dan jumlah hari hujan tidak berpengaruh terhadap penerimaan retribusi. Namun secara bersama-sama ditemukan bahwa seluruh variabel bebas merupakan regressor yang signifikan untuk variabel penerimaan retribusi parkir.
PEER ATTACHMENT DENGAN SELF-REGULATED LEARNING BAGI MAHASISWA UNIVERSITAS KATOLIK WIDYA MANDIRA KUPANG
Authors: Rohi Enasely Mega Wenyi 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara peer attachment dengan self-regulated learning pada mahasiswa semester satu Program Studi Bimbingan dan Konseling Universitas Katolik Widya Mandira Kupang. Penelitian ini juga menyelidiki korelasi antara kesadaran peer attachment dan self-regulated learning. Subyek dalam penelitian ini adalah seluruh mahasiswa semester satu yang berjumlah 81 orang. Pengambilan sampel melalui teknik purposive sampling. Pengumpulan data menggunakan 23 item pada skala peer attachment dengan nilai koefisien Cronbach α sebesar 0,854 dan 23 item pada skala self-regulated learning dengan nilai koefisien Cronbach α sebesar 0,860. Hasil penelitian ini menunjukkan bahwa sebagian besar siswa memiliki tingkat peer attachment yang sedang (65,43%) dan self-regulated learning sedang (61,72%). Selain itu, data menunjukkan bahwa tidak ada korelasi antara peer attachment dengan self-regulated learning karena nilai signifikansi p = 0,929 (p>0,05), yang artinya tidak ada hubungan antara kelekatan teman sebaya dengan self-regulated-learning.
"Stem Cells in Urology: A Promising Development for the Treatment of Urological Disorders"
Authors: Shah Ahmed  
Published: November 2023

Madam,
It was fascinating to read the latest research published in the Journal of Pakistan Medical Association (JPMA) on the utilisation of stem cells in urology. The study had some amazing findings, and I believe it has the power to revolutionise the treatment of urological disorders.1
Recent advances in stem cell research have opened new possibilities for treating various urological conditions. For example, findings have shown that stem cells can be used to promote tissue regeneration and repair in patients with urinary incontinence or erectile dysfunction.2 Additionally, stem cells can regenerate damaged renal tissue, offering the latest treatment options for patients with kidney disease.4
Apromising area of research includes use of mesenchymal stem cells (MSCs) to treat urological conditions. MSCs are multipotent cells that can specify into various cell types, including muscles, bones, and cartilage. They have been shown to up level the symptoms and improve quality of life in patients with urinary incontinence,They may also be very effective in treating a variety of urological conditions.2
One more area of research entails the use of induced pluripotent stem cells (iPSCs) in urology. iPSCs are reprogrammed from adult cells, like skin cells, into an embryonic-like state. They are differentiated into various cell types, making them a potentially important tool for regenerative medicine. Research has shown that iPSCs can be used to produce functional urothelial cells, which line the urinary tract and play a major role in bladder function.5
Overall, stem cell research in urology is a developing area that shows promise. It offers new treatment varieties for patients with urological conditions and has the potential to improve their quality of life. I strongly believe that this research will be of great interest to clinicians and researchers in this urology field, and I look forward to seeing further more developments in this exciting area of medicine.
It is also important to note that further research is strongly needed to fully explore the potential of stem cells in urology. This includes examining the long-term safety standards and efficacy of stem cell therapy, as well as identifying the optimal stem cell sources and delivery methods for variety of urological conditions. I strongly believe that ongoing research will continue to shed light on these important questions.
The Potential Weight Loss Benefits of Tirzepatide: A Double-edged Sword?
Authors: Nasim Muhammad Taha , Ali Ayesha , Nasim Muhammad Tabish 
Published: November 2023

Madam,
Tirzepatide, also known as Mounjaro, has become increasingly popular among diabetic patients due to its potential to aid in weight loss. However, with the growing demand for this medication for its weight-loss benefits, there are apprehensions that it may soon become scarce.
Tirzepatide, a dual Glucagon-like peptide (GLP-1) and Glucose-dependent insulinotropic polypeptide (GIP) receptor agonistis an injectable synthetic peptide with glucose-lowering effects.(1) It stimulates first- and second-phase insulin secretion, and reduce glucagon levels.
Since its approval by the FDA in late 2021, Tirzepatide has become increasingly popular among diabetic patients as it has reported a mean decrease of 1.53% in patients' HbA1C levels in the first 40 weeks of use, which is higher than other drugs available in the market(1,2). Many patients also reported significant weight loss after starting the medication, which has led to increased demand for the drug.
While this drug is yet to be approved by FDA for weight loss, it is expected that it will be approved for weight loss by mid of 2023. Despite that, some doctors already e off-label as a weight loss drug in people not suffering from Diabetes(3). This can lead to an increased demand for the drug as seen earlier in the case of Ozempic (semaglutide) in 2022 leading to an acute shortage (4). Pharmacies are already reporting low supplies of Tirzepatide, and some patients are facing trouble in getting their prescriptions filled(5).
For diabetic patients who are relying on Tirzepatide to manage their blood glucose levels and promote weight loss, this shortage could have serious consequences. Patients who are unable to acquire the drug may be forced to switch to other medications or try alternative treatments, which may not be as effective.
In conclusion, the recent surge in demand for Tirzepatide has led to concerns about a potential shortage of the medication. While the drug has shown promise in helping diabetic patients improve glycemic control and promote weight loss, patients need to have access to the medication when they need it. To help mitigate the shortage of Tirzepatide, some experts are calling for increased production of the drug and improved distribution channels to ensure that patients can continue to benefit from this promising treatment option.
Hyftor – An emerging therapy for Facial Angiofibromas: A letter to the editor
Authors: Zulfi Muhammad Hassan , Zainab Abbas  , Elahi Sana Jilani  
Published: November 2023

Tuberous Sclerosis Complex (TSC) is a rare autosomal dominant genetic disease caused by a deactivating mutation in one of the two tumour suppressor genes, TSC1 or TSC2.1,2 These mutations can lead to hyperactivation of the mammalian Target of Rapamycin (mTOR) signalling pathway, which in turn mediates cellular growth and proliferation. As the mTOR pathway is usually responsible for stimulating the synthesis of protein, cells' survival, and cell cycle progression.1,3 This causes the formation of multiple benign non-invasive tumours, called hamartoma, in different body tissues and organs.1,3
Facial Angiofibroma (FA) is the most prevalent skin manifestation of TSC.4 These are multiple, erythematous, small hamartomatous papules of around 1 to 3 mm in size formed by the excessive production of skin cells coupled with angiogenesis.3,4 The most classical sites of occurrence include the center of the face, alar grooves, cheeks, nose, and chin.3 FA has increased chances of bleeding; it can damage the eyesight and can cause psychological distress due to aesthetic disfiguration.4
Physical removal of FA is associated with pain, hyperpigmentation, scarring, bleeding, and recurrence of the lesions.4 Therefore, recently, on March 22, 2022, the FDA approved the topical use of Hyftor (Sirolimus, also known as Rapamycin mTOR inhibitor) for the treatment of FA.5
Hyftor has earned its position as the most appropriate treatment for FA in TSC due to its anti-tumour, anti-angiogenic and immunosuppressive properties, which highly favours this drug’s effectiveness and safety profile.1 It binds to the FK-binding protein-12 (FKBP-12), which in turn impedes the hyperactivity of mTOR, eventually causing the down-regulation of cellular growth. It also reduces levels of vascular endothelial growth factor levels depriving the tumour cells of their blood supply. Furthermore, it also halts the progression and proliferation of the cell cycle by blocking the response of T and B cell activation by cytokines.3
Long-term serious systematic side effects of mTOR inhibitors were overcome by the topical formulation of sirolimus.3,4 All concentrations of this drug are very well-tolerated with minor adverse effects, which include dry skin, application site irritation, burning sensation, and pruritis.3
Hyftor has proven to be a practical therapeutic innovation in the medical field due to its high specificity for mTOR and meager adverse effects profile. However, this drug requires additional large population-based studies and trials to substantiate further its efficacy and safety in patients with FA.