bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les sages-femmes catholiques et les bouleversements des possibles procréatifs (France, années 1940-1960)
Authors: Sage-Pranchère Nathalie 
Published: January 2024

Résumé
Les évolutions scientifiques et techniques notables en matière de procréation qui marquent les années 1940 à 1960 (insémination artificielle, inhibition hormonale de la fonction ovarienne) suscitent, au sein de l’Église catholique et parmi ses fidèles, tensions, interrogations et attentes. Ces pratiques confrontent en particulier les auxiliaires catholiques de la naissance, médecins et sages-femmes, à l’appréciation de leur acceptabilité morale. L’Association des sages-femmes catholiques constitue une des arènes où se déploient ces débats.
Effect of intra-seasonal variation in precipitation on seed germination and seedling growth in Iris atrofusca: implications for conservation
Authors: Volis Sergei 
Published: January 2024

Abstract
Understanding the modulating effect of environmental conditions on the germination of seeds constituting a persistent soil seed bank has both theoretical and practical merits. I studied the role of precipitation in the germination of seeds of the imperiled geophyte Iris atrofusca, which exhibits strong seed dormancy and intermittant germination over years. I wanted to know how a single significant rain event in one of the first several seasons after seed maturation and dispersal can affect seed germination and seedling growth in I. atrofusca. This is important because knowing the amount and time of such a rainfall event, one can imitate it by a single watering applied to an artificial soil seed bank, thus initiating or substantially increasing seed germination and improving seedling growth and therefore survival. Overall, the results imply that the most efficient in terms of both seed germination and seedling survival is supplementary irrigation equivalent to 40 mm rainfall applied as a single rain event to the artificial soil seed bank early in the first and second season, plus watering equivalent to 20–40 mm in the months when the amount of precipitation is low (below 20 mm) not only in the first and second, but also in subsequent seasons.
Variation in substrate nutritional composition and its effects on the growth, development, and nutrient composition of Rhynchophorus phoenicis Fabricius (Coleoptera: Curculionidae)
Authors: Debrah S.K. , Anankware J.P. , Malinga G.M. , Asomah S. , Obeng-Ofori D. 
Published: January 2024

Abstract
Consumption of African Palm Weevil larvae is a potential solution to the escalating need for protein in Ghana. Currently, insect farmers rely heavily on agricultural by-products, for their production. However, the changes in nutritional content of these substrates over the duration of the larval stage is not well understood as its decline could have a negative effect on the larval development. The palm weevil larvae were reared on eleven (11) substrates and the changes in the nutrient content of the substrates over time during the larval rearing duration, and their effect on larval survival, larval duration and larval weight were assessed. The substrates tested included cocoyam cake, spoilt onion, banana corm, spoilt garden eggs, coconut coir, cocoa pod, raphia palm, elephant ear corm, sliced false yam, sugarcane and palm yolk. The substrate samples were collected weekly from the first to the fourth week and analysed for crude fat, crude protein, ash and carbohydrate contents. The nutritional content of all the substrates did not differ in the first week. However, crude protein, crude fat and carbohydrate significantly differed in the second, third, and fourth weeks. Larval survival, larval duration and weight of larvae were significantly affected by the changes in the nutrient content of the substrates in the second, third and fourth weeks. The results showed that elephant ear corm, sliced false yam and palm yolk have necessary nutritional requirements to sustain the larvae during development.
A Case Study on Wind Speed Oscillations Offshore the West Coast of Central Taiwan
Authors: Chien Fang-Ching , Chang Chun-Wei , Teng Jen-Hsin , Hong Jing-Shan 
Published: January 2024

Abstract
This paper investigates a wind speed oscillation event that occurred near the coastline of central Taiwan in the afternoon of 17 February 2018, using data from observations and numerical simulations. The observed wind speeds at 100-m altitude displayed a fast-oscillating pattern of about 6 cycles between strong winds of approximately 21 m s−1 and weak winds of around 2 m s−1, with periods of about 10 min. The pressure anomalies fluctuated in antiphase with the wind speed anomalies. The synoptic analysis revealed the influence of a continental high pressure system, resulting in a cold-air outbreak over Taiwan. The cold north-northeasterly winds split into two branches upon encountering Taiwan’s topography, with ridging off the east coast and a lee trough off the west coast of Taiwan. Wind oscillations were detected in the low-level cold air offshore the west coast of Taiwan, depicted by wavelike structures in wind speeds, sea level pressure, and potential temperature. The perturbations were identified as Kelvin-Helmholtz billows characterized by regions of strong wind speeds, warm and dry air, sinking motions, and low pressure collocated with each other, while regions of weaker wind speeds, cooler and moister air, ascending motions, and high pressure were associated with each other. With terrain contributing to favorable conditions, the large vertical and horizontal wind shears resulted from the southward acceleration of low-level cold air and the northward movement of the lee trough played an important role in initiating the wind oscillations.
Imprint of Chaos on the Ocean Energy Cycle from an Eddying North Atlantic Ensemble
Authors: Uchida Takaya , Jamet Quentin , Dewar William K. , Deremble Bruno , Poje Andrew C. , Sun Luolin 
Published: January 2024

Abstract
We examine the ocean energy cycle where the eddies are defined about the ensemble mean of a partially air–sea coupled, eddy-rich ensemble simulation of the North Atlantic. The decomposition about the ensemble mean leads to a parameter-free definition of eddies, which is interpreted as the expression of oceanic chaos. Using the ensemble framework, we define the reservoirs of mean and eddy kinetic energy (MKE and EKE, respectively) and mean total dynamic enthalpy (MTDE). We opt for the usage of dynamic enthalpy (DE) as a proxy for potential energy due to its dynamically consistent relation to hydrostatic pressure in Boussinesq fluids and nonreliance on any reference stratification. The curious result that emerges is that the potential energy reservoir cannot be decomposed into its mean and eddy components, and the eddy flux of DE can be absorbed into the EKE budget as pressure work. We find from the energy cycle that while baroclinic instability, associated with a positive vertical eddy buoyancy flux, tends to peak around February, EKE takes its maximum around September in the wind-driven gyre. Interestingly, the energy input from MKE to EKE, a process sometimes associated with barotropic processes, becomes larger than the vertical eddy buoyancy flux during the summer and autumn. Our results question the common notion that the inverse energy cascade of wintertime EKE energized by baroclinic instability within the mixed layer is solely responsible for the summer-to-autumn peak in EKE and suggest that both the eddy transport of DE and transfer of energy from MKE to EKE contribute to the seasonal EKE maxima.

Significance Statement
The Earth system, including the ocean, is chaotic. Namely, the state to be realized is highly sensitive to minute perturbations, a phenomenon commonly known as the “butterfly effect.” Here, we run a sweep of ocean simulations that allow us to disentangle the oceanic expression of chaos from the oceanic response to the atmosphere. We investigate the energy pathways between the two in a physically consistent manner in the North Atlantic region. Our approach can be extended to robustly examine the temporal change of oceanic energy and heat distribution under a warming climate.
Comparative study of the clinical efficacy of subcostal thoracoscopy and median sternotomy in treating thymoma: a propensity score-matching analysis
Authors: Yin Xunliang , Xue Sha , Guo Yize , Cheng Shaoyi , Feng Zheng , Zhao Zhengwei , Zhou Yongan , Yuan Dongliang 
Published: January 2024

Objective This study was performed to evaluate the clinical efficacy of subcostal thoracoscopy and median sternotomy as surgical approaches for thymoma resection and lymph node dissection. The feasibility, safety, and clinical outcomes of subcostal thoracoscopy were compared with those of median sternotomy. Methods The clinical data of 335 patients with thymoma were retrospectively analyzed. The patients were divided into the subcostal thoracoscopy group and the median sternotomy group. Propensity score matching was performed to obtain comparable subsets of 50 patients in each group. A comparative analysis was conducted on various parameters. Results All surgeries were successful, and no conversions to open thoracotomy were required in the subcostal thoracoscopy group. Significant differences in the operative time, intraoperative blood loss, chest tube drainage duration, postoperative hospital stay, patient satisfaction scores, pain assessment, and postoperative complications were observed between the two groups. However, there was no significant difference in the number of lymph nodes or lymph node stations dissected intraoperatively between the two groups. Conclusion Subcostal thoracoscopy is not inferior to median sternotomy as a surgical approach for thymoma resection and lymph node dissection. Our research provides important new comparative data on minimally invasive thymoma resection.
Helmet Therapy for the Management of Deformational Plagiocephaly in Pediatric Patients with Shunted Hydrocephalus
Authors: Johnson Emily A. , Koller Gretchen M. , Jafrani Ryan , Patel Kamlesh , Naidoo Sybill , Strahle Jennifer M. 
Published: January 2024

Objective To evaluate the safety and efficacy of helmet therapy for deformational plagiocephaly in patients with shunted hydrocephalus. Design Retrospective chart review. Setting Institutional, tertiary-care hospital. Patients All patients at St. Louis Children's Hospital between 2014 and 2021 with shunted hydrocephalus who underwent helmet therapy for deformational plagiocephaly. Interventions Helmet therapy. Main Outcome Measures Cranial vault asymmetry (CVA), cranial vault asymmetry index (CVAI), and cephalic index (CI) were measured before and after completion of helmet therapy. Results There were 37 patients with shunted hydrocephalus and documented deformational plagiocephaly. Twelve were managed with helmet therapy. Average age at helmeting initiation and time between shunt placement and helmeting initiation was 5.8 and 4.6 months, respectively. Average CVA, CVAI, and CI at helmeting initiation and termination was 11.6, 7.98, and 85.2, and 6.95, 4.49, and 83.7, respectively. Average duration of helmeting was 3.7 months. CVA and CVAI were significantly lower after helmeting ( P = .0028 and .0021) and 11/12 patients had overall improvement in plagiocephaly. Conclusions Helmet therapy appears to be a safe and efficacious management strategy for deformational plagiocephaly in patients with shunted hydrocephalus. Despite the occasional need for additional fittings and surveillance beyond the normal schedule, in all cases appropriately fitting helmets were achieved and no major adverse events occurred. This cohort represents a proof of principle for the safety and efficacy of helmet therapy in patients with shunted hydrocephalus. Further work in larger prospective cohorts is needed to confirm these initial findings.
Radially adjustable stent retriever for mechanical thrombectomy in acute ischemic stroke: Improved first-pass effect with rapid-inflation deflation technique
Authors: Sreenivasan Sanjeev , Gupta Gaurav , Wu Robert , Nourollah-Zadeh Emad , Sun Hai , Nanda Anil , Sundararajan Srihari , Roychowdhury Sudipta 
Published: January 2024

Introduction Evidence for improved first-pass effect with the novel radially adjustable radio-opaque stent retriever Tigertriever is lacking. Objective To compare improvement in first pass success with Tigertriever using two different techniques—rapid inflation deflation (RID) and suction thrombectomy (ST). Methods Retrospective analysis of patients with acute ischemic stroke who underwent mechanical thrombectomy with Tigertriever at a single comprehensive stroke center. Results Thirty patients were included. Mean age was 72.8 years. Twelve patients (48%) experienced successful first passes with Tigertriever. Successful revascularization (modified thrombolysis in cerebral infarction (mTICI) 2b/3) was achieved in all (100%) patients who received RID or ST technique for thrombectomy. Good clinical outcome (modified Rankin score = 0–2) was noted in 40% (n = 10). Total mortality in the cohort was 8% (n = 2). RID and ST groups comprised of 10 and 15 patients, respectively. Five patients underwent MT with Tigertriever as a rescue device. RID vs ST No difference was noted in mean age (p = 0.27), gender (p = 0.29), location of occlusion (p = 0.46), and device used for first pass (p = 0.57). A 70% first-pass success rate in RID group and 37.5% in ST group was noticed (p = 0.06). Mean time from groin puncture to reperfusion (TICI 2b//3) was statistically similar (p = 0.29, RID: 19.9 min vs ST: 25 min). Both groups noted a 100% complete recanalization rate. The rate of mortality between the two groups were not statistically different (p = 0.46). Conclusion The preliminary first-pass success rates of RID technique with Tigertriever compared to ST technique, are encouraging. Longitudinal studies with longer follow up are needed to elucidate the smaller learning curve with this device.
Communication, Cognition and Competency Development in Healthcare: A Model for Integrating Cognitive Ethnography and Communication Skills Training in Clinical Interventions
Authors: Schwalbe Daria , Timmermann Connie , Gregersen Trine A , Steffensen Sune Vork , Ammentorp Jette 
Published: January 2024

OBJECTIVES The aim of this study was to conduct and evaluate the Blended Learning communication skills training program. The key objective was to investigate (i) how clinical intervention studies can be designed to include cognitive, organizational, and interactive processes, and (ii) how researchers and practitioners could work with integrated methods to support the desired change. METHODS The method combined design and implementation of a 12-week Blended Learning communication skills training program based on the Calgary-Cambridge Guide. The training was implemented in a patient clinic at a Danish university hospital and targeted all healthcare professionals at the clinic. Cognitive ethnography was used to document and evaluate healthcare professionals’ implementation and individual competency development, and support the design of in-situ simulation training scenarios. RESULTS Thirteen participants completed the program. The synergy within the teams, as well as the opportunities for participants to coordinate, share, discuss, and reflect on the received knowledge with a colleague or on-site researcher, affected learning positively. The knowledge transfer process was affected by negative feedback loops, such as time shortages, issues with concept development and transfer, disjuncture between the expectations of participants and instructors of the overall course structure, as well as participant insecurity and a gradual loss of motivation and compliance. CONCLUSION We propose a novel 3-step model for clinical interventions based on our findings and literature review. This model will effectively support the implementation of educational interventions in health care by narrowing the theory-practice gap. It will also stimulate desired change in individual behavior and organizational culture over time. Furthermore, it will work for the benefit of the clinic and may be more suitable for the implementation of communication projects than, for example, randomized setups.
BCMA- or GPRC5D-targeting bispecific antibodies in multiple myeloma: efficacy, safety, and resistance mechanisms
Authors: Lee Holly , Neri Paola , Bahlis Nizar J. 
Published: January 2024

Abstract
Bispecific antibodies that engage T cells to target B-cell maturation antigen or G-protein–coupled receptor class C group 5 member D have demonstrated remarkable efficacy in heavily pretreated relapsed or refractory multiple myeloma (MM), leading to the recent accelerated approval of teclistamab, elranatamab, and talquetamab by health agencies. Future challenges, however, remain to define their optimal dosing schedule and duration, sequencing, and integration with established anti-MM therapeutics as well as delineating the biological and clinical mediators of immune escape.
IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3
Authors: Zhu Ying , He Langyue , Zhu Yue , Yao Huici , Jiang Jianfeng , Lu Hongyan 
Published: January 2024

Abstract
Background
Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm infants, characterised by compromised alveolar development and pulmonary vascular abnormalities. Emerging evidence suggests that regulatory T cells (Tregs) may confer protective effects on the vasculature. Knockdown of their transcription factor, interferon regulatory factor 4 (IRF4), has been shown to promote vascular endothelial hyperplasia. However, the involvement of Tregs and IRF4 in the BPD pathogenesis remains unclear. This study aimed to investigate the regulation of Tregs by IRF4 and elucidate its potential role in pulmonary vasculature development in a BPD mouse model.

Methods
The BPD model was established using 85% hyperoxia exposure, with air exposure as the normal control. Lung tissues were collected after 7 or 14 days of air or hyperoxia exposure, respectively. Haematoxylin–eosin staining was performed to assess lung tissue pathology. Immunohistochemistry was used to measure platelet endothelial cell adhesion molecule-1 (PECAM-1) level, flow cytometry to quantify Treg numbers, and Western blot to assess vascular endothelial growth factor (VEGFA), angiopoietin-1 (Ang-1), forkhead box protein P3 (FOXP3), and IRF4 protein levels. We also examined the co-expression of IRF4 and FOXP3 proteins using immunoprecipitation and immunofluorescence double staining. Furthermore, we employed CRISPR/Cas9 technology to knock down the IRF4 gene and observed changes in the aforementioned indicators to validate its effect on pulmonary vasculature development in mice.

Results
Elevated IRF4 levels in BPD model mice led to FOXP3 downregulation, reduced Treg numbers, and impaired pulmonary vascular development. Knockdown of IRF4 resulted in improved pulmonary vascular development and upregulated FOXP3 level.

Conclusion
IRF4 may affect the protective role of Tregs in the proliferation of pulmonary vascular endothelial cells and pulmonary vascular development in BPD model mice by inhibiting the FOXP3 level.
Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis
Authors: Migliorini Filippo , Maffulli Nicola , Velaj Erlis , Bell Andreas , Kämmer Daniel , Hildebrand Frank , Hofmann Ulf Krister , Eschweiler Jörg 
Published: January 2024

AbstractBackgroundSeveral clinical investigations have compared different pharmacologic agents for the prophylaxis of venous thromboembolism (VTE). However, no consensus has been reached. The present investigation compared enoxaparin, fondaparinux, aspirin and non-vitamin K antagonist oral anticoagulants (NOACs) commonly used as prophylaxis following total hip arthroplasty (THA). A Bayesian network meta-analysis was performed, setting as outcomes of interest the rate of deep venous thrombosis (DVT), pulmonary embolism (PE) and major and minor haemorrhages.MethodsThis study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension statement for reporting systematic reviews incorporating network meta-analyses of healthcare interventions. All randomised controlled trials (RCTs) comparing two or more drugs used for the prophylaxis of VTE following THA were accessed. PubMed, Web of Science and Google Scholar databases were accessed in March 2023 with no time constraint.ResultsData from 31,705 patients were extracted. Of these, 62% (19,824) were women, with age, sex ratio, and body mass index (BMI) being comparable at baseline. Apixaban 5 mg, fondaparinux, and rivaroxaban 60 mg were the most effective in reducing the rate of DVT. Dabigatran 220 mg, apixaban 5 mg, and aspirin 100 mg were the most effective in reducing the rate of PE. Apixaban 5 mg, ximelagatran 2 mg and aspirin 100 mg were associated with the lowest rate of major haemorrhages, while rivaroxaban 2.5 mg, apixaban 5 mg and enoxaparin 40 mg were associated with the lowest rate of minor haemorrhages.ConclusionAdministration of apixaban 5 mg demonstrated the best balance between VTE prevention and haemorrhage control following THA.Level of evidenceLevel I, network meta-analysis of RCTs.
DiCleave: a deep learning model for predicting human Dicer cleavage sites
Authors: Mu Lixuan , Song Jiangning , Akutsu Tatsuya , Mori Tomoya 
Published: January 2024

Abstract
Background
MicroRNAs (miRNAs) are a class of non-coding RNAs that play a pivotal role as gene expression regulators. These miRNAs are typically approximately 20 to 25 nucleotides long. The maturation of miRNAs requires Dicer cleavage at specific sites within the precursor miRNAs (pre-miRNAs). Recent advances in machine learning-based approaches for cleavage site prediction, such as PHDcleav and LBSizeCleav, have been reported. ReCGBM, a gradient boosting-based model, demonstrates superior performance compared with existing methods. Nonetheless, ReCGBM operates solely as a binary classifier despite the presence of two cleavage sites in a typical pre-miRNA. Previous approaches have focused on utilizing only a fraction of the structural information in pre-miRNAs, often overlooking comprehensive secondary structure information. There is a compelling need for the development of a novel model to address these limitations.

Results
In this study, we developed a deep learning model for predicting the presence of a Dicer cleavage site within a pre-miRNA segment. This model was enhanced by an autoencoder that learned the secondary structure embeddings of pre-miRNA. Benchmarking experiments demonstrated that the performance of our model was comparable to that of ReCGBM in the binary classification tasks. In addition, our model excelled in multi-class classification tasks, making it a more versatile and practical solution than ReCGBM.

Conclusions
Our proposed model exhibited superior performance compared with the current state-of-the-art model, underscoring the effectiveness of a deep learning approach in predicting Dicer cleavage sites. Furthermore, our model could be trained using only sequence and secondary structure information. Its capacity to accommodate multi-class classification tasks has enhanced the practical utility of our model.