bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring gender differences in the relationship between gut microbiome and depression - a scoping review
Authors: Niemela Leila , Lamoury Gillian , Carroll Susan , Morgia Marita , Yeung Albert , Oh Byeongsang 
Published: February 2024

BackgroundMajor depressive disorder (MDD) exhibits gender disparities, and emerging evidence suggests the involvement of the gut microbiome, necessitating exploration of sex-specific differences.MethodsA review was conducted, encompassing a thorough examination of relevant studies available in Medline via Ovid, Embase via OvidSP, CINAHL, and PsycINFO databases from their inception to June 2023. The search strategy employed specific keywords and Medical Subject Headings (MeSH) terms tailored to major depressive disorder in women, encompassing unipolar depression, depressive symptoms, and dysbiosis.ResultsFive studies were included. Among the four studies, alterations in alpha (n=1) and beta diversity (n=3) in the gut microbiome of individuals with MDD were revealed compared to controls. Gender-specific differences were observed in four studies, demonstrating the abundance of specific bacterial taxa and highlighting potential sex-specific implications in MDD pathophysiology. Correlation analyses (n=4) indicated associations between certain bacterial taxa and the severity of depressive symptoms, with varying patterns between males and females. Studies (n=3) also highlighted promising findings regarding the potential utility of microbial markers in diagnosing MDD, emphasizing the crucial role of sex stratification in understanding the disease pathophysiology.ConclusionsThe findings underscore the importance of recognizing gender-specific differences in the composition of the gut microbiome and its relationship with MDD. Further comprehensive robust studies are required to unravel the intricate mechanisms underlying these disparities.
Interventions to promote health literacy among working-age populations experiencing socioeconomic disadvantage: systematic review
Authors: Singh Himal , Samkange-Zeeb Florence , Kolschen Jonathan , Herrmann Ruben , Hübner Wiebke , Barnils Núria Pedrós , Brand Tilman , Zeeb Hajo , Schüz Benjamin 
Published: February 2024

BackgroundExperiencing financial insecurity and being underserved is often associated with low health literacy, i.e., the ability to identify, obtain, interpret and act upon health information, which may result in poor health outcomes. Little is known about effective interventions for promoting health literacy among underserved populations. The objective of this systematic review is to summarize the literature on such interventions and identify characteristics that differentiate more effective interventions.MethodsFollowing PRISMA guidelines we searched the databases SCOPUS, Pubmed, Web of Science core collection and CINAHL. We included primary studies with a quantitative study design and control groups testing interventions to increase health literacy or health knowledge in underserved populations between 18 and 65 years. Where possible, we converted effect sizes into Cohen’s d and compared mean differences of intervention and control groups. Albatross plots were created to summarize the results according to different health literacy and health knowledge outcomes.ResultsWe screened 3,696 titles and abstracts and 206 full texts. In total, 86 articles were analyzed, of which 55 were summarized in seven albatross plots. The majority of the studies (n = 55) were conducted in the United States and had a randomized controlled study design (n = 44). More effective intervention approaches assessed needs of participants through focus group discussions prior to conducting the intervention, used bilingual educational materials, and included professionals fluent in the first languages of the study population as intervention deliverers. Additionally, the use of educational materials in video and text form, fotonovelas and interactive group education sessions with role playing exercises were observed to be effective.DiscussionAlthough the outcomes addressed in the included studies were heterogeneous, effective intervention approaches were often culturally sensitive and developed tailored educational materials. Interventions aiming to promote health literacy in underserved populations should hence consider applying similar approaches.Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323801, PROSPERO registration ID: CRD42022323801.
“Cyclist at 12 o’clock!”: a systematic review of in-vehicle advanced driver assistance systems (ADAS) for preventing car-rider crashes
Authors: Useche Sergio A. , Faus Mireia , Alonso Francisco 
Published: February 2024

IntroductionWhile Advanced Driver Assistance Systems (ADAS) have become a prominent topic in road safety research, there has been relatively little discussion about their effectiveness in preventing car collisions involving specific vulnerable road users, such as cyclists. Therefore, the primary objective of this systematic literature review is to analyze the available evidence regarding the effectiveness of in-vehicle ADAS in preventing vehicle collisions with cyclists.MethodsTo achieve this goal, this systematic review analyzed a selection of original research papers that examined the effectiveness of ADAS systems in preventing car-cyclist collisions. The review followed the PRISMA protocol, which led to the extraction of 21 eligible studies from an initial pool of 289 sources indexed in the primary scientific literature databases. Additionally, word community-based content analyses were used to examine the research topics and their links within the current scientific literature on the matter.ResultsAlthough the current number of studies available is still scarce (most sources focus on car-motorcyclist or car-pedestrian crashes), the overall quality of the available studies has been reasonably good, as determined by the selected evaluation methods. In terms of studies’ outcomes, the literature supports the value of in-vehicle ADAS for preventing car-cyclist crashes. However, threatful side effects such as unrealistic expectations of these systems and users’ overconfidence or desensitization are also highlighted, as well as the need to increase driver training and road user awareness.ConclusionThe results of this study suggest that Advanced Driver Assistance Systems have significant potential to contribute to the prevention of driving crashes involving cyclists. However, the literature emphasizes the importance of concurrently enhancing user-related skills in both ADAS use and road-user interaction through educational and training initiatives. Future research should also address emerging issues, such as ADAS-related behavioral ergonomics, and conduct long-term effectiveness assessments of ADAS in preventing car-cycling crashes and their subsequent injuries.Systematic review registrationPROSPERO, unique identifier CRD42024505492, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=505492.
Comparison of perception of stress and consumption of anxiolytics in hospital and out-hospital conditions: a cross-sectional study
Authors: Jovanović Željko , Pešut Sara , Miletić Bojan 
Published: February 2024

BackgroundThe workplace is a place where medical workers are exposed to extreme stress, particularly during medical emergencies or events of epidemic or pandemic proportions. Anxiolytic therapy is often used to overcome professional challenges. Deepening knowledge about the prevalence of the use of anxiolytics and the perception of stress among medical workers enables the timely recognition of problems and the preparation of measures to improve the working conditions and quality of life of medical workers. The study’s primary objective was to investigate whether there were differences in the usage of anxiolytics among healthcare professionals in and out of the hospital. In addition to the main objective, there are other objectives that have been established: To examine whether there are statistically justified differences in stress perceptions between hospital and outpatient healthcare professionals; 2. To examine the stress factors in the workplace in both hospital and outpatient settings. To compare the frequency of taking anxiolytics with respect to various variables (age, seniority, occupation and level of education); 4. determines the impact of working conditions on stress perception and life satisfaction in healthcare professionals. The design of research: Cross-sectional research.Materials and methodsThe research involved 159 healthcare professionals in Slavonski Brod: 96 employees of the General Hospital “Dr. Josip Benčević” and 63 employees of the Health Center and the Institute for Emergency Medicine of Brodsko-Posavina County. Respondents were able to participate in the study by filling out questionnaires online. The questionnaire was designed to be voluntary and anonymous and contained 53 questions.ResultsStatistically significant differences were shown in the perception of stress, which is greater in hospital staff, than in the difference between stressors in the workplace, where hospital staff showed higher values in all categories, but three factors are more significant differences: “Organization of the workplace and financial issues,” “Conflicts and communication at work” and “Professional and intellectual requirements.” There are significant differences in the frequency of using anxiolytics with the assistance of a psychiatrist. Working conditions have a much greater impact on the perception of stress and life satisfaction in hospital staff, while in hospital staff only a weak link between the perception of stress and life satisfaction is expressed. Anxiolytics are consumed by 27.10% of hospital workers and 23.80% of outside-the-hospital workers.ConclusionThe consumption of anxiolytic drugs by healthcare professionals in hospital and outpatient conditions does not make a significant difference, but they do have statistically significant differences in their perception of stress.
The impact of minimally-invasive esophagectomy operative duration on post-operative outcomes
Authors: Tupper Haley I. , Roybal Belia O. , Jackson Riley W. , Banks Kian C. , Kwak Hyunjee V. , Alcasid Nathan J. , Wei Julia , Hsu Diana S. , Velotta Jeffrey B. 
Published: February 2024

BackgroundEsophagectomy, an esophageal cancer treatment mainstay, is a highly morbid procedure. Prolonged operative time, only partially predetermined by case complexity, may be uniquely harmful to minimally-invasive esophagectomy (MIE) patients for numerous reasons, including anastomotic leak, tenuous conduit perfusion and protracted single-lung ventilation, but the impact is unknown. This multi-center retrospective cohort study sought to characterize the relationship between MIE operative time and post-operative outcomes.MethodsWe abstracted multi-center data on esophageal cancer patients who underwent MIE from 2010 to 2021. Predictor variables included age, sex, comorbidities, body mass index, prior cardiothoracic surgery, stage, and neoadjuvant therapy. Outcomes included complications, readmissions, and mortality. Association analysis evaluated the relationship between predictor variables and operative time. Multivariate logistic regression characterized the influence of potential predictor variables and operative time on post-operative outcomes. Subgroup analysis evaluated the association between MIE &gt;4 h vs. ≤4 h and complications, readmissions and survival.ResultsFor the 297 esophageal cancer patients who underwent MIE between 2010 and 2021, the median operative duration was 4.8 h [IQR: 3.7–6.3]. For patients with anastomotic leak (5.1%) and 1-year mortality, operative duration was elevated above the median at 6.3 h [IQR: 4.8–8.6], p = 0.008) and 5.3 h [IQR: 4.4–6.8], p = 0.04), respectively. In multivariate logistic regression, each additional hour of operative time increased the odds of anastomotic leak and 1-year mortality by 39% and 19%, respectively.ConclusionsEsophageal cancer is a poor prognosis disease, even with optimal treatment. Operative efficiency, a modifiable surgical variable, may be an important target to improve MIE patient outcomes.
The Fourier–Legendre Series of Bessel Functions of the First Kind and the Summed Series Involving 1F2 Hypergeometric Functions That Arise from Them
Authors: Straton Jack C. 
Published: February 2024

The Bessel function of the first kind JNkx is expanded in a Fourier–Legendre series, as is the modified Bessel function of the first kind INkx. The purpose of these expansions in Legendre polynomials was not an attempt to rival established numerical methods for calculating Bessel functions but to provide a form for JNkx useful for analytical work in the area of strong laser fields, where analytical integration over scattering angles is essential. Despite their primary purpose, one can easily truncate the series at 21 terms to provide 33-digit accuracy that matches the IEEE extended precision in some compilers. The analytical theme is furthered by showing that infinite series of like-powered contributors (involving 1F2 hypergeometric functions) extracted from the Fourier–Legendre series may be summed, having values that are inverse powers of the eight primes 1/2i3j5k7l11m13n17o19p multiplying powers of the coefficient k.
CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation
Authors: Key Jana , Gispert Suzana , Kandi Arvind Reddy , Heinz Daniela , Hamann Andrea , Osiewacz Heinz D. , Meierhofer David , Auburger Georg 
Published: February 2024

The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia. In the filamentous fungus Podospora anserina, CLPP loss leads to longevity. CLPP substrates are selected by CLPX, an AAA+ unfoldase. CLPX is known to target delta-aminolevulinic acid synthase (ALAS) to promote pyridoxal phosphate (PLP) binding. CLPX may also influence cofactor association with other enzymes. Here, the evaluation of P. anserina metabolomics highlighted a reduction in arginine/histidine levels. In Mus musculus cerebellum, reductions in arginine/histidine and citrulline occurred with a concomitant accumulation of the heme precursor protoporphyrin IX. This suggests that the increased biosynthesis of 5-carbon (C5) chain deltaALA consumes not only C4 succinyl-CoA and C1 glycine but also specific C5 delta amino acids. As enzymes responsible for these effects, the elevated abundance of CLPX and ALAS is paralleled by increased OAT (PLP-dependent, ornithine delta-aminotransferase) levels. Possibly as a consequence of altered C1 metabolism, the proteome profiles of P. anserina CLPP-null cells showed strong accumulation of a methyltransferase and two mitoribosomal large subunit factors. The reduced histidine levels may explain the previously observed metal interaction problems. As the main nitrogen-storing metabolite, a deficiency in arginine would affect the urea cycle and polyamine synthesis. Supplementation of arginine and histidine might rescue the growth deficits of CLPP-mutant patients.
Selection and Validation of Reference Genes for Gene Expression in Bactericera gobica Loginova under Different Insecticide Stresses
Authors: Wei Hongshuang , Zhang Jingyi , Yang Mengke , Li Yao , Guo Kun , Qiao Haili , Xu Rong , Liu Sai , Xu Changqing 
Published: February 2024

Insecticide resistance has long been a problem in crop pest control. Bactericera gobica is a major pest on the well-known medicinal plants Lycium barbarum L. Investigating insecticide resistance mechanisms of B. gobica will help to identify pesticide reduction strategies to control the pest. Gene expression normalization by RT-qPCR requires the selection and validation of appropriate reference genes (RGs). Here, 15 candidate RGs were selected from transcriptome data of B. gobica. Their expression stability was evaluated with five algorithms (Delta Ct, GeNorm, Normfinder, BestKeeper and RefFinder) for sample types differing in response to five insecticide stresses and in four other experimental conditions. Our results indicated that the RGs RPL10 + RPS15 for Imidacloprid and Abamectin; RPL10 + AK for Thiamethoxam; RPL32 + RPL10 for λ-cyhalothrin; RPL10 + RPL8 for Matrine; and EF2 + RPL32 under different insecticide stresses were the most suitable RGs for RT-qPCR normalization. EF1α + RPL8, EF1α + β-actin, β-actin + EF2 and β-actin + RPS15 were the optimal combination of RGs under odor stimulation, temperature, developmental stages and both sexes, respectively. Overall, EF2 and RPL8 were the two most stable RGs in all conditions, while α-TUB and RPL32 were the least stable RGs. The corresponding suitable RGs and one unstable RG were used to normalize a target cytochrome P450 CYP6a1 gene between adult and nymph stages and under imidacloprid stress. The results of CYP6a1 expression were consistent with transcriptome data. This study is the first research on the most stable RG selection in B. gobica nymphs exposed to different insecticides, which will contribute to further research on insecticide resistance mechanisms in B. gobica.
Pengaruh Pemberian Akupresur terhadap Nyeri Persalinan Fase Aktif
Authors: Prastyoningsih Aris , Wahyuni Siti , Pangesti Christin Bumi , Andini Dwi Margareta 
Published: February 2024

Contraction pain is main problem for patients in the 1st stage of labor in active phase. Labor pain in first stage of the active phase can be treated with acupressure at points L14 and SP6. The L14 and SP6 acupressure points can stimulate release of hormone oxytocin from pituitary, which will stimulate uterine contractions, thereby helping the labor process to be better and reducing pain during labor. The aim of this study was to determine how acupressure impacts labor pain during active phase of the first stage. Design of this research is one group pre-post test. This study involved 30 women giving birth normally, in 1st stage of the active phase, who had no abnormalities or injuries at L14 and SP6 locations. Ttool used is Wong Baker Pain Scale. The results showed that maternal patients in 1st active phase had an average pain scale of 8.03 before being given acupressure, and pain scale dropped to 3.26 after being given acupressure. There was a significant difference between the groups before and after acupressure with a p value of 0.000. There is an effect of giving acupressure on the intensity of pain in mothers giving birth during the first active phase
Desain Hubungan Balok-Kolom Gedung 9 Lantai Menggunakan SNI 2847:2019 dan SNI 1726:2019 (Studi Kasus: Gedung Fakultas Keguruan dan Ilmu Pendidikan Universitas Borneo Tarakan)
Authors: Swasanto Harfri , Hernadi Ahmad 
Published: February 2024

ABSTRACT : Design of beam-column connections needs to be planned by assuming plastic joints at the beam and column base also in reducing structural failure at the joint when cyclic earthquake loads occur. Designed a 9-story building with a total height of 37 m using a dual system and earthquake resistant element design with SNI 2847: 2019, SNI 1726: 2019, and SNI 1727: 2020. The primary data of soil case study data from boring results in 2011, the average value of N ̅ = 13.309 15, namely the soft soil site class (SE) in boring hole 2, KDS IV-D value SDS = 0.558 and SD1 = 0.4185. Concrete compressive quality K-350 Kg/m3, steel grade using BjTS 420 MPa. Seismic design permits using response spectrum analysis of irregular frequency results, Failure mechanism of the frame to bear lateral loads 33% (x-direction), 37% (y-direction) and structural walls 67% (x-direction), 63% (y-direction), fundamental frequency of the structure 1.504 seconds percentage 70.8% (UY) and 1.437 seconds percentage 59.7% (UX), number of variations 90% mode 10 and 100% mode 45. Strong Colomn Weak Beam (SCWB) K1 1st floor against x-direction column crawl beam ΣMn-Column = 3118.22 kNm Σ1.2Mn-Beam = 156.97 kNm and y-direction ΣMn-Column = 2681.76 kNm Σ1.2Mn-Beam = 2245.37 kNm. The beam-column connection (HBK) reinforcement design uses diameters namely; 13mm, and 16mm, the spacing (s) in the beam-column connection uses 90mm, 130mm, and 300mm.Keywords: Beam-column connections, Design, Earthquake. ABSTRAK: Desain hubungan balok-kolom perlu direncanakan dengan mengasumsikan terjadi sendi-plastis pada balok dan dasar kolom juga dalam mereduksi kegagalan struktur pada joint ketika beban gempa berulang (siklik terjadi. Perancangan gedung 9 lantai ketinggian total 37 m menggunakan sistem ganda dan desain elemen tahan gempa dengan SNI 2847:2019, SNI 1726:2019, dan SNI 1727:2020. Data primer data studi kasus tanah hasil boring tahun 2011, Nilai rata-rata = 13,309 15 yakni kelas situs tanah lunak (SE) pada lubang boring 2, KDS IV-D nilai SDS = 0,558 dan SD1= 0,4185. Mutu tekan beton K-350 Kg/m3, kelas baja menggunakan BjTS 420 MPa. Gempa desain izin menggunakan analisis respons spektrum hasil kosekuensi ketidakberaturan, Mekanisme kegagalan rangka memikul beban lateral 33% (arah-x), 37% (arah-y) dan dinding struktur 67% (arah-x), 63% (arah-y), frekuensi fundamental struktur 1,504 detik persentase 70,8% (UY) dan 1,437 detik persentase 59,7% (UX), jumlah ragam 90% mode 10 dan 100% mode 45. Strong Colomn Weak Beam (SCWB) K1 lantai 1 terhadap balok merangkak kolom arah-x ΣMn-Kolom = 3118,22 kNm Σ1,2Mn-Balok = 156,97 kNm dan arah-y ΣMn-Kolom = 2681,76 kNm Σ1,2Mn-Balok = 2245,37 kNm. Desain tulangan hubungan balok-kolom (HBK) menggunakan diameter yakni; 13mm, dan 16mm, spasi (s) pada hubungan balok-kolom menggunakan 90mm, 130mm, dan 300mm.Kata kunci: Desain, Gempa, Hubungan Balok-Kolom.
Design of a spin–orbit-torque-based self-terminated nonvolatile register for a write/leakage-energy-minimized backup operation
Authors: Suzuki Daisuke , Hanyu Takahiro 
Published: February 2024

Abstract
A self-terminated nonvolatile (NV) register that is a key component of a energy-efficient LSI is proposed and its impact on minimizing write and leakage energies during a backup operation before a power-off mode is presented by combining spin–orbit-torque (SOT) devices with CMOS circuitry. The self-terminated NV-register can automatically cut off the write current pulse by continuously monitoring the voltage change due to the state transition of the SOT device. Moreover, the write completion signals can be utilized for a flag whether the circuit can go into the power-off mode which results in the minimization of leakage energy consumption. A case study is performed using a 45nm CMOS technology which results in 71% of total energy reduction in the backup operation compared to that of a typical worst-case design.
Direct atomization of water drops using a transverse vibrating plate ultrasonic source
Authors: Igarashi Ryuichi , Tsukamoto Yusuke , Asami Takuya , Miura Hikaru 
Published: February 2024

Abstract
In this study, we investigated a method to atomize water drops directly using an ultrasonic source equipped with a transverse vibrating plate. The atomization amount increased with the electric power to the ultrasonic source and the amount of water supplied, and when the electric power was 25 W, the full amount of water supplied (approximately 90 ml min−1) was atomized. Thus, a large amount of water could be atomized.