bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enablers and Hindrances of Lifestyle Changes Among Patients With Atrial Fibrillation
Authors: Liu Mengdi , Zhang Qianghuizi , Liu Leyang , Liu Weiwei 
Published: November 2023

BackgroundAtrial fibrillation (AF) seriously affects the health status and quality of life of affected patients. However, the lifestyle changes recommended by the guidelines for patients are not ideal. Hence, understanding the factors that promote and hinder healthy behavior changes in patients with AF is crucial for self-management.ObjectiveThe aims of this study were to understand the factors enabling and hindering health behaviors in patients with AF and to provide a reference for promoting health management among these patients.MethodsUsing the purposive sampling method, 22 patients with AF admitted to the Cardiac Center of Beijing Chaoyang Hospital, Capital Medical University, from March 2021 to June 2021 were selected for in-depth face-to-face interviews. The thematic analysis method was used to summarize and refine the themes.ResultsThe following 2 themes and 15 subthemes were eventually extracted by analyzing and summarizing the interview data. The 7 factors facilitating health behaviors in patients with AF were risk perception, outcome expectancy, behavioral intention, action plan, response plan, self-efficacy, and social support. There were 8 hindering factors: personal preferences and habits, specific customary culture, weak self-control, accessibility of exercise conditions, symptom-related distress, cognitive weakness, multiple medication use, and insufficient awareness of condition monitoring.ConclusionsThe factors affecting health behaviors in patients with AF are complex, and healthcare providers should reinforce the facilitators of health behaviors in these patients and provide them with targeted interventions against hindering factors. Results can be used to develop health behavior intervention programs for patients with AF.
Effect of Daily Activity Record-Based Self-monitoring Intervention on the Perception of Physical Sensations in Patients With Chronic Heart Failure
Authors: Matsuda Misako , Saito Nao , Izawa Kazuhiro P. , Taniguchi Ryoji , Shogaki Junko , Miyawaki Ikuko 
Published: November 2023

Background
To prevent rehospitalization for heart failure (HF), patients need to be able to perceive physical changes that occur at the onset of HF exacerbation and seek early help.

Objective
The aim of this study was to evaluate the effect of a self-monitoring intervention on patients' perceptions of physical sensations during daily activities in the context of HF via a randomized controlled trial.

Methods
Participants (N = 70) were randomly assigned to the intervention (received daily activity record-based self-monitoring intervention support; group A) or control (only explained the measured results from the records; group B) group. Group A reflected on and described the physical sensations in their daily activities within 1 month after discharge. Outcome measures were assessed at 1 month after the intervention using the European Heart Failure Self-care Behavior Scale, Evaluation Scale for Self-Monitoring by patients with Heart Failure, clinical events, physical activity, and sleep.

Results
There was no significant difference in the change in the “asking for help” subscale score of the European Heart Failure Self-care Behavior Scale between the groups (+0.7 vs +0.4 points, P = .716). Group A had improved score on the self-monitoring subscale related to “concern about how movements affect body” from baseline (from 12.7 to 14.0 points, P = .026). There was no significant effect of self-monitoring intervention support on the first rehospitalization related to HF and all-cause death (log-rank χ2 = 0.432, P = .511). A significant difference in moderate-intensity physical activity between the groups was observed (+4.6 vs −0.5 minutes, P = .029).

Conclusions
A focused strategy that enables patients to perceive their physical sensations and promotes early help-seeking behavior is needed.
Exploring the Relationship Between Techno-Unreliability at Work and Burnout
Authors: Meyer Sophie-Charlotte , Tisch Anita 
Published: November 2023

ObjectiveWith the growing dissemination of digital technologies in the workplace, technologies itself and related factors are increasingly discussed as an additional source of work stress, often referred to as technostress. This article explores whether techno-unreliability as a dimension of technostress is associated with burnout.MethodsWe perform linear regression analyses based on a large representative sample of German employees collected in 2019. We distinguish between information and communication technology users (n= 4702) and tool users (n= 1953). Interaction models explore whether individual and workplace-related factors might moderate the relationship.ResultsThe results indicate that the more frequently employees experience techno-induced interruptions (as an indicator for techno-unreliability), the stronger their burnout symptoms. Interaction models reveal that social support and job autonomy might buffer this association.ConclusionsEnsuring reliable technology and technical support can reduce employee stress.
Agentic processes in cultural evolution: relevance to Anthropocene sustainability
Authors: Richerson Peter J. , Boyd Robert T. , Efferson Charles 
Published: November 2023

Humans have evolved culturally and perhaps genetically to be unsustainable. We exhibit a deep and consistent pattern of short-term resource exploitation behaviours and institutions. We distinguish agentic and naturally selective forces in cultural evolution. Agentic forces are quite important compared to the blind forces (random variation and natural selection) in cultural evolution and gene-culture coevolution. We need to use the agentic policy-making processes to evade the impact of blind natural selection. We argue that agentic forces became important during our Pleistocene history and into the Anthropocene present. Human creativity in the form of deliberate innovations and the deliberate selective diffusion of technical and social advances drove this process forward for a long time before planetary limits became a serious issue. We review models with multiple positive feedbacks that roughly fit this observed pattern. Policy changes in the case of large-scale existential threats like climate change are made by political and diplomatic agents grasping and moving levers of institutional power in order to avoid the operation of blind natural selection and agentic forces driven by narrow or short-term goals.
This article is part of the theme issue ‘Evolution and sustainability: gathering the strands for an Anthropocene synthesis’.
Maternal Mortality and Last Mile Challenges: Improved Perspective for Leapfrogging
Authors: Ahmed Shabbir , Tanbi Fatema Akter , Rahman Hossain Zillur 
Published: November 2023

AbstractBackgroundReducing maternal mortality to zero is one of the 3 targeted agendas of the International Conference of Population and Development (ICPD). Though global improvements in align with SDGs commitment have witnessed comparative development but in the case of reaching zero agenda there are still much more improvements to make.ObjectivesUnderstanding the bottom-level reality with field experiences while also paying attention to the policy voices to understand the last mile stumbling blocks.MethodsReality check along with expert opinions working at the field level and beneficiary consultations were the primary components for this study. Three specific modalities (i) field-level consultations with the stakeholders, (ii) facility inspection and (iii) roundtable discussion were the specific tools used for this study.ResultsFindings show that in Bangladesh, substantial inequities exist both in the use of facility-based maternal healthcare with scarce and the absence of competent birth attendants for home births. Moreover, socio-cultural norms and the socioeconomic status of the families contribute to maternal deaths. The poor family setting, the hospital referral system, and the familial understanding of the overall maternal healthcare are largely responsible for maternal deaths.ConclusionAll these issues related to maternal deaths need proper attention to leap forward to overcome the last mile challenges. Determined focus on defining and identifying the last mile population, breaking the pedagogical limitations and institutional barriers with an additional focus on the last mile research to reach the underserved population is imperative to reach the last mile.ProblemImproving maternal health is one of three ICPD 3 zeroes priority, and a nested target in the third goal of the Sustainable Development Goals (SDGs). Alarmingly, maternal mortality is the third highest cause of death among women aged 15 to 49 in Bangladesh contributing to stalling the progress ahead in achieving SDGs.What is Already KnownThe business as usual and contextual factors including poverty, distance to health facilities, lack of information, inadequate services, cultural practices, education coupled with governance and macro-structural factors, private sector infrastructure investment and health finance are greatly responsible for maternal mortality to overcome last mile challenge.What this Paper AddsThis study identifies barriers that limit the availability and access to quality maternal health services at all levels of the health system focusing the grass root maternal services. Underlines the prevailing inadequate and absence of services delivery and suggests necessary steps to address the last mile challenges towards ending preventable maternal deaths,
GGA1 interacts with the endosomal Na+/H+ Exchanger NHE6 governing localization to the endosome compartment
Authors: Ma Li , Kasula Ravi Kiran , Ouyang Qing , Schmidt Michael , Morrow Eric M. 
Published: November 2023

ABSTRACTMutations in the endosomal Na+/H+ exchanger (NHE6) cause Christianson syndrome (CS), an X-linked neurological disorder. Previous studies have shown that NHE6 functions in regulation of endosome acidification and maturation in neurons. Using yeast two-hybrid screening with the NHE6 carboxyl-terminus as bait, we identify Golgi-associated, Gamma adaptin ear containing, ARF binding protein 1 (GGA1) as an interacting partner for NHE6. We corroborated the NHE6-GGA1 interaction using co-immunoprecipitation (co-IP): using over-expressed constructs in mammalian cells; and co-IP of endogenously-expressed GGA1 and NHE6 from neuroblastoma cells, as well as from mouse brain. We demonstrate that GGA1 interacts with organellar NHEs (NHE6, NHE7 and NHE9) but not with cell-surface localized NHEs (NHE1 and NHE5). By constructing hybrid NHE1/NHE6 exchangers, we demonstrate that the cytoplasmic tail of NHE6 is necessary and sufficient for interactions with GGA1. We demonstrate the co-localization of NHE6 and GGA1 in cultured, primary hippocampal neurons, using super-resolution microscopy. We test the hypothesis that the interaction of NHE6 and GGA1 functions in the localization of NHE6 to the endosome compartment. Using subcellular fractionation experiments, we show that NHE6 is mis-localized in GGA1 knockout cells wherein we find less NHE6 in endosomes but more NHE6 transport to lysosomes, and more Golgi retention of NHE6 with increased exocytosis to the surface plasma membrane. Consistent with NHE6 mis-localization, and Golgi retention, we find the intra-luminal pH in Golgi to be alkalinized. Our study demonstrates a new interaction between NHE6 and GGA1 which functions in the localization of this intra-cellular NHE to the endosome compartment.
Stacking models of brain dynamics improves prediction of subject traits in fMRI
Authors: Griffin B , Ahrends C , Alfaro-Almagro F , Woolrich M , Smith S , Vidaurre D 
Published: November 2023

AbstractBeyond structural and time-averaged functional connectivity brain measures, the way brain activity dynamically unfolds can add important information when investigating individual cognitive traits. One approach to leveraging this information is to extract features from models of brain network dynamics to predict individual traits. However, there are two potential sources of variation in the models’ estimation which will in turn affect the predictions: first, in certain cases, the estimation variability due to different initialisations or choice of inference method; and second, the variability induced by the choice of the model hyperparameters that determine the complexity of the model. Rather than merely being statistical noise, this variability may be useful in providing complementary information that can be leveraged to improve prediction accuracy. We propose stacking, a prediction-driven approach for model selection, to leverage this variability. Specifically, we combine predictions from multiple models of brain dynamics to generate predictions that are accurate and robust across multiple cognitive traits. We demonstrate the approach using the Hidden Markov Model, a probabilistic generative model of brain network dynamics. We show that stacking can significantly improve the prediction of subject-specific phenotypes, which is crucial for the clinical translation of findings.
Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent anti-PD-L1- and anti-NKG2A-based adjuvant immunotherapy
Authors: Patin Emmanuel C , Nenclares Pablo , Hak Charleen Chan Wah , Dillon Magnus T , Patrikeev Anton , McLaughlin Martin , Grove Lorna , Foo Shane , Soliman Heba , Barata Joao P , Marsden Joanna , Baldock Holly , Roulstone Victoria , Kyula Joan , Burley Amy , Hubbard Lisa C , Pedersen Malin , Smith Simon A , Clancy-Thompson Eleanor , Melcher Alan A , Ono Masahiro , Rullan Antonio , Harrington Kevin J 
Published: November 2023

AbstractDespite some success in other cancer types, the results of combining radiotherapy/chemoradiotherapy and immune checkpoint blockade have been disappointing in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). For such a potentially radiocurable disease, there remains an imperative to explore novel combination approaches. Here, we show that combining ATR inhibition with radiotherapy (ATRi/RT) increases the frequency of highly activated NKG2A/PD-1 double-positive T cells in patients and in animal models of HNSCC. Addition of dual anti-NKG2A and anti-PD-1/-PD-L1 blockade to ATRi/RT in the adjuvant, post-radiotherapy setting induces a robust antitumour immune response in HNSCC preclinical models. Efficacy of the combination regimen relies on CD40/CD40L costimulatory-mediated infiltration of activated/proliferative/memory CD8 and CD4 conventional T cells with persistent or new T cell receptor (TCR) signalling, respectively, as defined by tracking of T cell dynamics. In this favourable therapeutic context, TCR sequencing shows increased richness of the TCR repertoire and the emergence of numerous and large TCR clusters that share antigen specificity in response to full combination therapy. Collectively, our data point towards promising combination approaches for future clinical testing in HNSCC.
Easy, fast and reproducible Stochastic Cellular Automata with chouca
Authors: Génin Alexandre , Dupont Guillaume , Valencia Daniel , Zucconi Mauro , Ávila-Thieme M. Isidora , Navarrete Sergio A. , Wieters Evie A. 
Published: November 2023

ABSTRACTStochastic cellular automata (SCA) are models that describe spatial dynamics using a grid of cells that switch between discrete states over time. They are widely used to understand how small-scale processes scale up to affect ecological dynamics at larger spatial scales, and have been applied to a wide diversity of theoretical and applied problems in all systems, such as arid ecosystems, coral reefs, forests, bacteria, or urban growth.Despite their wide applications, SCA implementations are often ad-hoc, lacking performance, guarantees of correctness and poorly reproducible.De novoimplementation of SCA for each specific system and application also represents a major barrier for many practitioners. To provide a unifying, well-tested technical basis to this class of models and facilitate their implementation, we built chouca, an R package that translates definitions of SCA models into compiled code, and runs simulations in an efficient way.chouca supports SCA based on rectangular grids where transition probabilities are defined for each cell, with performance typically two to three orders of magnitude above typical implementations in interpreted languages (e.g. R, Python), all while maintaining an intuitive interface in the R environment. Exact and mean-field simulations can be run, and both numerical and graphical results can be easily exported.Besides providing better reproducibility and accessibility, a fast engine for SCA unlocks novel, computationally intensive statistical approaches, such as simulation-based inference of ecological interactions from field data, which represents by itself an important avenue for research. By providing an easy and efficient entry point to SCAs, chouca lowers the bar to the use of this class of models for ecologists, managers and general practitioners, providing a leveled-off reproducible platform while opening novel methodological approaches.
Experimental evolution for the recovery of growth loss due to genome reduction
Authors: Hitomi Kenya , Ishii Yoichiro , Ying Bei-Wen 
Published: November 2023

AbstractAs the genome encodes the information crucial for cell growth, a sizeable genomic deficiency often causes a significant decrease in growth fitness. Whether and how the decreased growth fitness caused by genome reduction could be compensated by evolution was investigated here. Experimental evolution with anEscherichia colistrain carrying a reduced genome was conducted in multiple lineages for approximately 1,000 generations. The growth rate, which was largely declined due to genome reduction, was considerably recovered, associated with the improved carrying capacity. Genome mutations accumulated during evolution were significantly varied across the evolutionary lineages and were randomly localized on the reduced genome. Transcriptome reorganization showed a common evolutionary direction and conserved the chromosomal periodicity, regardless of highly diversified gene categories, regulons, and pathways enriched in the differentially expressed genes. Genome mutations and transcriptome reorganization caused by evolution, which were found to be dissimilar to those caused by genome reduction, must have followed divergent mechanisms in individual evolutionary lineages. Gene network reconstruction successfully identified three gene modules functionally differentiated, which were responsible for the evolutionary changes of the reduced genome in growth fitness, genome mutation, and gene expression, respectively. The diversity in evolutionary approaches improved the growth fitness associated with the homeostatic transcriptome architecture as if the evolutionary compensation for genome reduction was like all roads leading to Rome.
miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice
Authors: Narayanan Ramanathan , Levone Brunno Rocha , Winterer Jochen , Nanda Prakruti , Ranft Alexander Mueller , Fiore Roberto , Germain Pierre-Luc , Mihailovich Marija , Testa Giuseppe , Schratt Gerhard 
Published: November 2023

AbstractSocial deficits are frequently observed in patients suffering from neurodevelopmental disorders, but the molecular mechanisms regulating sociability are still poorly understood. We recently reported that the loss of the microRNA cluster miR-379-410 leads to hypersocial behavior and anxiety in mice. Here, we show that ablating miR-379-410 in excitatory neurons of the postnatal mouse hippocampus recapitulates hypersociability, but not anxiety. At the cellular level, miR-379-410 loss in excitatory neurons leads to increased excitatory synaptic transmission and upregulation of an actomyosin gene network. Re-expression of three cluster miRNAs, as well as pharmacological inhibition of the actomyosin activator ROCK, was sufficient to reinstate normal sociability in miR-379-410 knockout mice. Several actomyosin genes and miR-379-410 family members were reciprocally dysregulated in isogenic human iPSC-derived neurons harboring a deletion present in Williams-Beuren-Syndrome patients, which are characterized by hypersocial behavior. Together, our results unveil a novel microRNA-actomyosin pathway involved in the control of sociability.
In situobservation and range extension of the first monoplacophoranNeopilina galatheae
Authors: Chen Chong , Jamieson John W. 
Published: November 2023

AbstractMonoplacophoran molluscs have been dubbed ‘living fossils’ due to their absence in the fossil record for about 375 million years, untilNeopilina galatheaeLemche, 1957 was trawled off Costa Rica in 1952. Since then, over 35 species of living monoplacophorans have been discovered. Nevertheless,in situobservations of these rare deep-sea animals remain scant. Here, we observed and collected an intact specimen ofN. galatheaeusing a remotely operated vehicle from 2460 m deep on the Eastern Galápagos Spreading Center. The animal was found attached to the glassy surface of solidified basalt lava flow, and no feeding trails were found near the animal. Such hard substrate is in contrast with previous records that were trawled on sand and mud, suggestingNeopilinacan be found on a wide range of substrates. This is the first time this species was collected since 1959, and represents a southeast range extension of about 1000 km for the species.
Chromosome-level assembly of the gray fox (Urocyon cinereoargenteus) confirms the basal loss ofPRDM9in Canidae
Authors: Armstrong Ellie E. , Bissell Ky L. , Fatima H. Sophia , Heikkinen Maya A. , Jessup Anika , Junaid Maryam O. , Lee Dong H. , Lieb Emily C. , Liem Josef T. , Martin Estelle M. , Moreno Mauricio , Otgonbayar Khuslen , Romans Betsy W. , Royar Kim , Adler Mary Beth , Needle David B. , Harkess Alex , Kelley Joanna L. , Mooney Jazlyn A. , Mychajliw Alexis M. 
Published: November 2023

AbstractReference genome assemblies have been created from multiple lineages within the Canidae family, however, despite its phylogenetic relevance as a basal genus within the clade, there is currently no reference genome for the gray fox (Urocyon cinereoargenteus). Here, we present a chromosome-level assembly for the gray fox (U. cinereoargenteus), which represents the most contiguous, non-domestic canid reference genome available to date, with 90% of the genome contained in just 34 scaffolds and a contig N50 and scaffold N50 of 59.4 and 72.9 Megabases (Mb), respectively. Repeat analyses identified an increased number of simple repeats relative to other canids. Based on mitochondrial DNA, our Vermont sample clusters with other gray fox samples from the northeastern US and contains slightly lower levels of heterozygosity than gray foxes on the west coast of California. This new assembly lays the groundwork for future studies to describe past and present population dynamics, including the delineation of evolutionarily significant units of management relevance. Importantly, the phylogenetic position ofUrocyonallows us to verify the loss ofPRDM9functionality in the basal canid lineage, confirming that pseudogenization occurred at least 10 million years ago.