bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of early outcome of laparoscopic versus open left hemicolectomy in patients with left colon cancer
Authors: Badr Mohamed L.A. , Ammar Mohamed S. , Elwahab Ali Mohamed G.A. , Al-Abbasy Mahmoud M. 
Published: January 2024

Background
Colorectal cancer is a prominent global health concern, and while laparoscopic surgeries offer minimally invasive benefits, there is a noted underrepresentation of left-sided colon cancer in current research. This study seeks to bridge the gap by assessing the safety and efficacy of laparoscopic (LC) versus open left hemicolectomy (OC) in patients with left-side colon cancer.

Patients and methods
This prospective, nonrandomized study was conducted from May 2020 to May 2022 at Menoufia University Hospital and Damanhur Medical National Institute, enrolling 40 patients diagnosed with left-sided colonic carcinoma. Participants were divided into two groups: 20 underwent LC, and 20 had OC. The primary outcomes were operative time, blood loss, and incision length, with several secondary outcomes like analgesic needs and postoperative hospital stay.

Results
Both groups showed no significant differences in age, BMI, and other demographic characteristics. However, intraoperatively, the OC group completed procedures significantly faster than the LC group, with average times of 2.58 h compared with 4.48 h (P<0.001). Postoperatively, the LC group showed faster recovery, taking 2.35 days (P=0.019) to resume a liquid diet compared with 4.45 days for the OC group and 2.35 days (P<0.001) to pass the first flatus versus 3.45 days in the OC group. The LC group also had a shorter hospital stay, averaging 4.1 days compared with the OC’s 8.75 days (P<0.001), and harvested a higher number of lymph nodes (13 vs. 11.85, P<0.001).

Conclusion
The findings of this study demonstrate that LC and OC were comparable as regards intraoperative and postoperative complications. On the other hand, LC was considered a good and effective method for resection of left colonic carcinoma as it has many benefits, such as early recovery and short hospital stay.
Laparoscopic Roux-En-Y gastric bypass versus mini-gastric bypass for the treatment of morbid obesity and effect on glucagon-like peptide-1 level: a randomized comparative study
Authors: Kandel Mohamed M. , Elkeleny Mostafa R. , Header Doaa A. , Korayem Islam M. , Hassan Mohamed M. 
Published: January 2024

Background
The gold standard malabsorptive technique for patients who are morbidly obese that promotes sustained weight loss is laparoscopic Roux-en-Y gastric bypass (LRYGB). An alternative that has gained popularity is laparoscopic mini-gastric bypass (LMGB), which has the advantages of being more technically straightforward, needing less time during surgery, and having a higher food tolerance. This study compares the short-term effects of LMGB and LRYGB on weight reduction and postoperative levels of glucagon-like peptide-1 (GLP-1).

Methods
This prospective study included 50 morbidly obese patients who were randomly assigned to receive either LRYGB or LMGB, with 25 patients/group in the period from March 2020 to February 2021.

Results
Group B experienced a much shorter hospital stay and operation time than group A. There was no discernible difference between the two groups in terms of intraoperative errors or postoperative problems. Throughout the follow-up period, the patients’ weights and BMI dramatically fell in both groups, with the LMGB group seeing a much larger mean excess BMI reduction percent. Preoperative comorbidities were significantly resolved in both operations, and there was no discernible difference between the two groups. GLP-1: Following surgery, both groups exhibit a noteworthy rise in postprandial GLP-1 levels.

Conclusions
Compared with LRYGBP, the LMGB technique produced a greater weight loss with a similar efficiency on metabolic control.
Survival rate between total thyroidectomy and lobectomy in papillary thyroid cancer
Authors: Alhanafy Saad S. , Elsisy Alaa A.E. , Alanazi Ahmed B. , Abuelfetouh Mohamed , Alabassy Mahmoud M. 
Published: January 2024

Background
Regarding papillary thyroid cancer, comparisons between lobectomy (LT) and total thyroidectomy (TT) have not addressed major risks to reliable conclusions drawn from observational data. This research aimed to evaluate the survival rate following thyroidectomy (TT) and LT for papillary thyroid carcinoma.

Methods
A total of 155 patients with papillary thyroid cancer who had LT or TT at Menoufia University Hospitals between January 2018 and April 2023 were included in this retrospective cohort analysis. Overall survival was the main result, which was assessed using inverse probability weighting on the propensity score and flexible parametric survival models.

Results
Of the patients receiving treatment, 78% were female and the median age was 48 (range: 37–59). There were no statistically significant differences in the 5-year overall survival between individuals who underwent a complete thyroidectomy or LT. Furthermore, we did not find any statistically significant variation in survival by subgroups, such as age (<65 or ≥65), tumor size (<4 cm or ≥4 cm), or projected risk of death.

Conclusion
Based on our data, TT, independent of tumor size, patient age, or overall risk of mortality, is unlikely to provide a survival benefit over lobectomy.
Evaluation of the Curative Effect of Topical Insulin Application on Burn Wounds of Non-Diabetic Patients with Minor to Moderate Partial Thickness Burns
Authors: Mohamed Ahmad E. , Mahmoud Radwa E.-S. 
Published: January 2024

Background and aim
Burns are one of the most common traumatic conditions. Heat, chemicals, electrical currents, and radiation are all examples of physical or chemical factors responsible for burns. A previously conducted study of diabetic individuals found that the local injection of insulin for wound treatment promoted the processes of angiogenesis and fibrosis with no significant negative effects. This study was aimed at evaluating the curative effects of local insulin application in the treatment of minor to moderate partial-thickness burns in nondiabetic burned patients.

Patients and methods
This was a case–controlled, randomized clinical study of 50 patients of both sexes, nondiabetic, with minor to moderate partial-thickness burns, aged 20–55 years, who were allocated into two groups: the study group that received topical insulin application and the control group that received the usual treatment. Each group was treated for 14 days. The following items were assessed in both groups: wound healing time, pain, scar healing, incidence of adverse reactions, and Sequential Organ Failure Assessment score.

Results
Across the two groups, the wound healing time and the average number of burn dressing changes in the study group were substantially less than those in the control group. Before intervention, there was no significant difference in the level of pain, while after intervention, the study group was substantially less than the control group (P<0.05) in the level of pain and scar healing.

Conclusion
Topical insulin application was effective and harmless in the treatment of minor to moderate partial-thickness burns in nondiabetic burned patients.
Adding quilting sutures to Y plasty to avoid postmastectomy lateral dog ears in patients with large cup sized breast
Authors: Alhussini Mahmoud A. , Awad Ahmed T. , Kholosy Hassan 
Published: January 2024

Background
Total mastectomy without reconstruction is a commonly adopted procedure for managing breast cancer. Formation of lateral dog ears is very common, especially with large breast cup size. In this study, we assessed the feasibility of adding quilting sutures to the Y plasty technique to achieve more acceptable results in the avoidance of lateral dog ears in comparison to using Y plasty alone.

Methods
The study included 150 female patients with large breast cup size. Patients were randomized 2 : 1 between group A and group B. In group A, 3–5 quilting sutures were added to the lateral flaps of Y plasty. In group B, Y plasty only was adopted without the quilting sutures. Patients were followed up at 4-month intervals for at least 1 year. One year after surgery, patients filled in a questionnaire inquiring about the degree of discomfort in the area beneath the arm. Also, a plastic surgeon was asked to give a score about the cosmetic outcome of managing lateral dog ears both at 3 weeks and 12 months after surgery.

Results
Both groups were comparable in regard to age, BMI, breast cup size, and postoperative radiotherapy exposure. Patients in group A had better scores for satisfaction with the shape of the scar and comfort with the bra. Also, the blinded cosmetic outcome assessment was in favor of group A.

Conclusion
Adding quilting sutures to the lateral flap of the V-Y plasty technique is associated with a better cosmetic outcome in the management of lateral dog ears in mastectomy patients with large breast cup size.
Role of laparoscopic lumbar sympathectomy in chronic limb-threatening ischemia due to nonreconstructable peripheral arterial disease
Authors: Ahmed Ahmed H.S. , Mahmoud Amr A. , Abdelmalek Wageeh F. , Rizk Mohamed A.E.M. 
Published: January 2024

Background
Lumbar sympathectomy (LS) was traditionally performed for intermittent claudication but is now eclipsed by revascularization for that indication. However, it retains a role in the management of chronic limb-threatening ischemia and other conditions causing lower limb pain with or without ischemia. In this study, we identify its role in the management of chronic limb-threatening ischemia in cases of nonreconstructable peripheral arterial disease.

Aim
The main aim of this study is to determine if LS procedure has an effective role in limb salvage and pain control for patients with nonreconstructable peripheral limb ischemia. The primary endpoint was limb salvage in the target limb, while the secondary endpoint targeted assessment of pain improvement in the same limb.

Patients and methods
This study is a prospective single-arm cohort study conducted using 21 patients between the January 1, 2021 and the January 1, 2023 at two hospitals, Ain Shams University Hospital and Nasser Institute Hospital. Patients complained of nonreconstructable peripheral arterial disease and there was no chance for revascularization either endovascular or surgical bypass.

Results
This study included 60 patients; one patient was excluded due to being lost to follow-up, and presented with nonconstructable critical limb ischemia between the January 1, 2021 and the January 1, 2023. There were 42 (70%) males and 18 (30%) females. Follow-up for all patients was subjected to measurement of ankle brachial pressure index, digital pulse oximetry, toe pressure and numerical rating scale for pain scoring preoperative and postoperative. On follow-up we noticed that there was no change in either ankle brachial pressure index or toe pressure immediately postoperatively and after 12 months. However, the digital pulse oximetry showed significant improvement immediately postoperatively from 68.40±7.36 to 81.15±12.23 with a P value of 0.001. The most remarkable improvement was found in pain scoring immediately, 1, 3, 6, and 12 months postoperatively with P values showing statistical significance. As for limb salvage, there was a 100% limb survival for 3 months. After 6 months, only nine cases underwent above-knee amputation, one of them was due to severe limb infection, and three cases had minor amputation ‘toe amputation.’ We noticed that three out of the nine cases suffering major amputations had femoropopliteal disease. Of the patients, 80% suffered no minor or major amputation, while 15% had major amputations beyond the tarsometatarsal joint and only 5% underwent minor toe amputation or debridement. Fortunately, there was no mortality among the studied cases.

Conclusion
Retroperitoneoscopic LS is significantly less invasive than open surgical technique with fewer wound complications and less hospital stay period and offers a longer duration of pain relief and less incidence of recurrence of manifestations.
Excision hemorrhoidectomy versus laser hemorrhoidoplasty in second and third degree hemorrhoids: a prospective cohort study
Authors: Mahmoud Mahmoud A. , Ouf Tarek I.A. , Ghaly Ayman M.B. , El Aziz Heba T.A. 
Published: January 2024

Background
Hemorrhoids are considered the commonest benign anorectal diseases globally, being the most annoying anorectal problem. They commonly present with discomfort, prolapse, and bleeding.

Aim
The aim of this study is to compare between surgical excision of hemorrhoids and laser hemorrhoidoplasty (LHP) in the treatment of second and third-degree hemorrhoids.

Patients and methods
The study was conducted on 80 patients. The patients were divided into two equal groups. First group underwent surgical excision of hemorrhoids while the second group underwent LHP. We compared the outcomes of surgical excision of hemorrhoids with LHP in the of duration of surgery, intraoperative bleeding, postoperative pain, postoperative hospital stay, and the time needed for work return and short and long-term postoperative complications.

Results
LHP had a significantly lower time of surgery, intraoperative blood loss and pain postoperative with no effect on defecation. There were no significant difference in the complications postoperative.

Conclusion
LHP is a safe and effective modality in treatment of second and third degree hemorrhoids and being more superior than traditional surgical excision of hemorrhoids.
Impact of bariatric surgery on morbidly obese hypothyroid patients
Authors: Afifi Amr H. , Nagy Mostafa , Naga Mohamed Abo 
Published: January 2024

Background
Obesity is considered a risk factor for many health issues, which includes cardiovascular, psychological, neurological, and musculoskeletal diseases. It is known that overt hypothyroidism induces obesity if not properly managed. The aim of current study is to evaluate effect of different bariatric surgeries on morbidly obese hypothyroid patients regarding thyroid-stimulating hormone, free T4, and dose of levothyroxine supplement needed.

Patients and methods
A retrospective cohort study was conducted on patients with morbid obesity and hypothyroidism from January 2021 to January 2023. We included patients more than 18 years old, obese (BMI >40 kg/m2 or >35 kg/m2 in association with uncontrolled comorbidities such as diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea) with hypothyroidism undergoing bariatric surgery. Secondary objectives include assessment of weight reduction after bariatric surgery as excess weight loss and excess body mass index loss.

Results
The mean excess weight loss was 44.2%, while the mean excess body mass index loss was 88.22%. Sleeve gastrectomy surgery had the highest percentage of patients who reduced their thyroid hormone replacement (THR) dose (61.9%), followed by the Mini Gastric Bypass (MGB) group (47.5%). The Roux-en-Y Gastric Bypass (RGB) group had the highest percentage of patients who were off their THR dose (56.3%), followed by the sleeve group (31.8%). Only one (4.5%) patient in the sleeve group had an increased THR dose.

Conclusions
Bariatric surgery has a significant impact on the THR dose in patients with hypothyroidism. The type of surgery also affects the percentage of patients who reduced, stopped, or maintained their THR dose.
Clinical and pathological parameters predicting pathologic complete response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer
Authors: Ashoor Ahmed S. , Elshazly Walid G. , El Gendi Saba M. , Darwish Azza M. 
Published: January 2024

Objective
The aim of this study is to identify possible clinical predictors of complete response after neoadjuvant treatment in locally advanced rectal cancer (LARC) patients.

Background
Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision and postoperative adjuvant chemotherapy for LARC is the standard of care with a local recurrence rate of only 5–10%.
On the other hand, various people react differently to neoadjuvant CRT. Neoadjuvant CRT is well received by the majority of patients, with a pathologic complete response (pCR) occurring in 10–30% of cases.
Predicting the response to neoadjuvant CRT is crucial from a clinical standpoint, since patients with pCR have a better prognosis and may require a different treatment plan than patients without pCR.
As a result, predicting pCR following neoadjuvant CRT for rectal cancer continues to be extremely useful for treating physicians.
To identify the clinical and pathological variables linked to a full response to preoperative CRT for rectal cancer, we assessed a group of patients with pCR in this study.

Patients and methods
The study included 153 patients with LARC that were enrolled in the study based on specific inclusion and exclusion criteria. Patients were treated by standard neoadjuvant therapy. Surgical resection was planned for 6–8 weeks after the completion of neoadjuvant CRT, irrespective of the response to CRT.
Pathological examination was performed to assess pathological response in the resected specimen. pCR was defined as the absence of viable tumor cells in the surgical specimen, including lymph nodes.

Results
After neoadjuvant chemoradiation, the pCR rate for rectal cancer patients was 20.8%; patients were split into pCR and non-pCR groups. Age, sex, BMI, performance score, tumor stage, tumor differentiation, tumor location, and surgical method were all evenly distributed across the two groups. The results of the multivariate analysis showed that pretreatment lymph node status, tumor size, and a carcinoembryonic antigen level of less than or equal to 5 ng/ml were independent risk factors of an elevated likelihood of pCR, as was an interval of more than or equal to 8 weeks between the completion of chemoradiation and treatment.

Conclusion
The pCR in rectal cancer following neoadjuvant chemoradiation is predicted by pretreatment carcinoembryonic antigen level of less than or equal to 5 ng/ml, an interval of more than or equal to 8 weeks between the end of chemoradiation and surgical resection, tumor size greater than 5 cm, and pretreatment lymph node status. By utilizing these predictive variables, we are able to forecast patients’ outcomes and create flexible treatment plans. In certain, very specific situations, a wait-and-see policy might be appropriate.
The Relationship between Healthy Eating Index and Lipid Profile in Healthy Individuals: A Systematic Review
Authors: Faraji Hossein , Jamshidi Sanaz , Ferrie Suzie , Azar Pouria Sefidmooye 
Published: January 2024

Abstract

Background:
The Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI) are instruments developed by competing American research teams, aiming to assess the level of adherence to a dietary pattern, claimed to prevent chronic illness conditions such as dyslipidemia. This systematic review evaluated cross-sectional studies examining the association between HEI/AHEI score and the lipid profile in healthy participants.

Methods:
The systematic review was Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) compliant, and a search process was conducted through Scopus, Web of Knowledge, Google Scholar, Cochrane, PubMed, and ScienceDirect up to November 2022. Studies assessing the relationship between HEI/AHEI and lipid profile (low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)) were eligible for inclusion. The statistical differences in outcomes, anthropometric indices, and demographic data were extracted from the selected studies. Also, the quality assessment of studies was performed using the Newcastle–Ottawa scale.

Results:
The systematic search presented 17 cross-sectional studies. Most of the studies revealed a significant correlation between HEI score and lipid profile (LDL-C, HDL-C, TG, and TC) (P < 0.05), while a few of them indicated a significant relationship between AHEI score and these factors. Overall, the elevation of HEI/AHEI score was associated with the improvement in lipid profile (P < 0.05), though this association was more obvious for HEI compared with AHEI.

Conclusions:
Overall, the results of the study indicated that an improved lipid profile in healthy individuals is associated with a higher score in either HEI or AHEI. Further research in the future is required to confirm the claim.
Multidisciplinary model of teacher training: Empowering teachers to identify dyslexia in an integrated school setup
Authors: Raju Suma , Sahana Kashyap , Narasimhan Srirangam Vijayakumar 
Published: January 2024

Abstract

Purpose:
The purpose of the present study was to train teachers using a multidisciplinary approach and to document the effect of this training on their awareness regarding dyslexia, knowledge of dyslexia, and the identification of children with dyslexia.

Materials and Method:
The study included 100 primary school teachers (23 males and 77 females) having Kannada as their mother tongue and English as their second language. A questionnaire in Kannada was developed by the investigators to collect the responses before and after the teacher training from the primary school teachers about knowledge of dyslexia. The questionnaire was developed based on the Dyslexia Assessment for Languages in India (DALI).

Results:
The mean responses of the participants were higher during post-training compared to pre-training conditions. The standard deviation values were higher during pre-training compared to post-training conditions. Wilcoxon signed-rank test revealed that there was a statistically significant difference between the ratings of pre-training and post-training conditions. Therefore, it was inferred that training teachers to identify the characteristics of dyslexia significantly improved the knowledge of the teachers on general facts and myths about dyslexia, signs, and symptoms exhibited by children with dyslexia.

Conclusions:
The findings of the present study revealed that a structured multidisciplinary model of teacher training programs focusing on the knowledge and skills to identify possible dyslexic children can be very effective to prepare the teachers to identify and manage these children in a school setup where professional help is limited.