bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between dialysis modality and adherence to immunosuppression after kidney transplantation—A single-center study
Authors: Ortiz Fernanda , Salonsalmi Aino , Helanterä Ilkka 
Published: January 2025

Background
Patients with end-stage kidney disease often prefer home-based dialysis due to higher self-efficacy, which relates to improved medical treatment adherence. Kidney transplantation (KT) success depends on adhering to immunosuppressive medication post-transplant.

Objectives
To investigate whether adherence post-kidney transplantation (KT) and patients’ attitudes toward immunosuppression were influenced by their prior dialysis type modality. Additionally, the study examined if adherence and patient’s attitudes towards immunosuppression are associated with kidney graft survival.

Methods
This cross-sectional single-center study included 201 KT patients. Adherence was assessed using BAASIS and the coefficient of variation of calcineurin inhibitors (COV-CNI). Patient attitudes towards medication were evaluated using the Q-method. Pill burden, comorbidity score and HRQoL and medication complexity, were scored. Cox regression was applied to determine KT survival outcomes over a 14-year follow-up period (until Dec 2021).

Results
Prior dialysis modality was not associated with adherence to immunosuppression post-KT evaluated by BAASIS on average 4.7 years post-KT. Previous in-center hemodialysis patients had a higher CNI-COV (p = 0.011). The Q-sort analysis identified fully adherent patients linked to profile 1 (organized, resilient) whereas profile 2 patients were more careless. Patients linked to profile 3 (challenging, nervous) had higher education, a higher pill burden, and experienced more immunosuppression side effects. Death-censored graft loss increased by 7.6% with each additional pill, quadrupled if one dose of immunosuppression was missed, and increased by 2.9% for each point of COV-CNI rise.

Conclusions
Adherence to immunosuppression post-KT using BAASIS was not associated with prior dialysis type, despite in-center hemodialysis patients showing the highest COV-CNI. Taking COV-CNI into account, managing missed doses of immunosuppressants, and exploring patient attitudes could potentially enhance adherence and consequently improve KT survival.
Preliminary screening of new biomarkers for sepsis using bioinformatics and experimental validation
Authors: Wang Hao , Xiong Wei , Zhong Wu , Hu Yingchun 
Published: January 2025

Background
The morbidity and mortality of sepsis remain high, and so far specific diagnostic and therapeutic means are lacking.

Objective
To screen novel biomarkers for sepsis.

Methods
Raw sepsis data were downloaded from the Chinese National Genebank (CNGBdb) and screened for differentially expressed RNAs. Key genes with predictive value were identified through weighted correlation network analysis (WGCNA) and meta-analysis and survival analysis using multiple public databases. Core genes were analyzed for functional enrichment using Gene Set Enrichment Analysis(GSEA). The core genes were localized using single-cell sequencing. qPCR was used to validate the core genes.

Results
Differential analysis yielded a total of 5125 mRNA. WGCNA identified 5 modules and screened 3 core genes (S100A11, QPCT, and IFITM2). The prognosis of sepsis patients was strongly linked to S100A11, QPCT, and IFITM2 based on meta-analysis and survival analysis(P < 0.05).GSEA analysis showed that S100A11, QPCT, and IFITM2 were significantly enriched in ribosome-related pathways. S100A11 and QPCT were widely distributed in all immune cells, and QPCT was mainly localized in the macrophage cell lineage. In the sepsis group, the qPCR results showed that S100A11, QPCT, and IFITM2 expression levels were significantly higher in the sepsis group(P < 0.05).

Conclusion
In this study, S100A11, QPCT, and IFITM2 were screened as new potential biomarkers for sepsis. Validated by bioinformatics analysis and qPCR, these genes are closely associated with the prognosis of sepsis patients and have potential as diagnostic and therapeutic targets.
Modelling sensory attenuation as Bayesian causal inference across two datasets
Authors: Eckert Anna-Lena , Fuehrer Elena , Schmitter Christina , Straube Benjamin , Fiehler Katja , Endres Dominik 
Published: January 2025

Introduction
To interact with the environment, it is crucial to distinguish between sensory information that is externally generated and inputs that are self-generated. The sensory consequences of one’s own movements tend to induce attenuated behavioral- and neural responses compared to externally generated inputs. We propose a computational model of sensory attenuation (SA) based on Bayesian Causal Inference, where SA occurs when an internal cause for sensory information is inferred.

Methods
Experiment 1investigates sensory attenuation during a stroking movement. Tactile stimuli on the stroking finger were suppressed, especially when they were predictable. Experiment 2 showed impaired delay detection between an arm movement and a video of the movement when participants were moving vs. when their arm was moved passively. We reconsider these results from the perspective of Bayesian Causal Inference (BCI). Using a hierarchical Markov Model (HMM) and variational message passing, we first qualitatively capture patterns of task behavior and sensory attenuation in simulations. Next, we identify participant-specific model parameters for both experiments using optimization.

Results
A sequential BCI model is well equipped to capture empirical patterns of SA across both datasets. Using participant-specific optimized model parameters, we find a good agreement between data and model predictions, with the model capturing both tactile detections in Experiment 1 and delay detections in Experiment 2.

Discussion
BCI is an appropriate framework to model sensory attenuation in humans. Computational models of sensory attenuation may help to bridge the gap across different sensory modalities and experimental paradigms and may contribute towards an improved description and understanding of deficits in specific patient groups (e.g. schizophrenia).
Italian Gothic: An Edinburgh Companion, Marco Malvestio and Stefano Serafini (eds) (2023)
Authors: Saggini Francesca 
Published: January 2025

Review of: Italian Gothic: An Edinburgh Companion, Marco Malvestio and Stefano Serafini (eds) (2023)
Edinburgh: Edinburgh University Press, 255 pp.,
ISBN 978-1-47449-016-0, h/bk, £90
ISBN 978-1-47449-018-4, e-book, £24.99
Evaluation of cumulative rainfall and rainfall event–duration threshold based on triggering and non-triggering rainfalls: Northern Thailand case
Authors: Chinkulkijniwat Avirut , Salee Rattana , Yubonchit Somjai , La Duong Hai , Horpibulsuk Suksun , Hoy Menglim 
Published: January 2025

Abstract
A recently introduced rainfall threshold for landslide early warning systems combined a cumulative rainfall threshold with a rainfall event–duration (ED) threshold. Cumulative rainfall with rainfall event–duration, known as the CED threshold, was reported to perform better than the conventional ED threshold. However, the establishment of the CED threshold was based on a frequentist approach which required an adequate number of landslide-triggering rainfall data. An alternative to the use of landslide-triggering rainfall data is the use of non-triggering rainfall data. These rainfall events supply much bigger amount of data to the susceptibility model. Although the establishment of a rainfall threshold based on non-triggering rainfall events is seldom considered, previous scholars reported that this approach has produced better results than the conventional approach based on landslide-triggering events. This study investigates the reliability and prediction performance of the CED threshold based on non-triggering rainfall data. The performance of this threshold, designated as the negative-CED (CEDN) threshold, was compared with the positive-CED (CEDP) threshold based on landslide-triggering rainfall data. North Thailand, a landslide hot spot, was chosen as the study area. The proposed threshold was assessed from three skill scores, including (1) the true positive fraction (TPF), (2) the false positive fraction (FPF), and (3) the positive predictive value (PPV), and their variations over the range of threshold uncertainties. Rather than possessing lower uncertainties of the threshold parameters, the negative threshold provided better compromise predictions of TPF and FPF scores than the positive thresholds. Integrating the cumulative rainfall threshold and an event-based rainfall threshold resulted in a significant improvement in FPF scores, and hence enhanced the compromise predictions of TPF and FPF scores. Keeping in mind that the negative thresholds were not established from landslide data, care must be taken when using these thresholds and it is recommended that they should be applied only to areas where landslide data are limited.
Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience
Authors: Arshad Muhammad Fahad , Solanki Sam , Dancyger-Stevens Luka , Karunanayaka Madushani , Loh Ee-Wen , Htoon Kyaw Naing , Turki Mohanad , Munir Alia 
Published: January 2025

AbstractOmissions or delays in desmopressin can result in serious patient harm in patients with arginine vasopressin deficiency (AVP-D), formally known as cranial diabetes insipidus. Desmopressin administration practice in hospitals has not been thoroughly investigated previously. This study evaluated desmopressin prescription and administration practice at a large tertiary centre. A retrospective electronic case notes review of all admissions (≥24 h) with AVP-D between 2018 and 2021 at Sheffield Teaching Hospitals was undertaken. The outcomes were defined as the total number of missed and delayed doses, time to prescription and administration from admission and incidence of dysnatraemias. A qualitative survey to determine knowledge of AVP-D and desmopressin among staff members was also carried out. In total, 102 admissions were identified, of which 38% of admissions were via emergency department (ED). The total number of missed and delayed doses were 132/1315 (10.0%) and 139/1283 (10.9%), respectively. Of all admissions, 33% had ≥1 missed doses, while ≥1 doses were delayed in 54% admissions. ED rates of desmopressin prescription were low at 5%. The most common reasons documented for missed or delayed doses were unavailability of desmopressin followed by inability of the patient to take the medication. Median (interquartile range) prescription and administration times from admission were 5.6 (2.7–10.7) and 15.1 (8.7–27.0) h, respectively. The incidence of inpatient hypernatraemia and hyponatraemia was 7.6 and 30.4%, respectively. The staff survey showed below-average knowledge of the condition, advocating for an urgent need for education.Plain language summaryAVP-D is a life-threatening condition requiring desmopressin to prevent severe dehydration and death. During hospitalisation, these patients are more vulnerable due to restricted desmopressin access and a lack of awareness among hospital staff. This study evaluates desmopressin prescription practice at a large European hospital and confirms that delays occur frequently in real world. We recommend that desmopressin should be listed as a critical drug and education packages should be introduced for hospital staff.
La Ensoñación de la materia. Fuerzas que mueven las películas The Boogie Woogie Ghost y Puebla de María Jerez y Silvia Zayas
Authors: Pérez Royo Victoria 
Published: January 2025

En este texto estudio las películas The Boogie Woogie Ghost y Puebla de María Jerez y Silvia Zayas desde algunas tensiones y fuerzas que las atraviesan y que las vinculan con otras piezas escénicas, fílmicas, exposiciones, conferencias, y tesis doctorales de ellas y de artistas afines. Algunas de estas fuerzas son seducción y encantamiento de la mirada, atención a las dimensiones de lo invisible; deseo de incertidumbre, visión compleja de la fábrica imaginativa del mundo, curiosidad por los lugares y cosas de lo cotidiano y lo íntimo, o la ensoñación de la materia, entre otras.
ОСНОВНЫЕ НАПРАВЛЕНИЯ И ФАКТОРЫ, ОПРЕДЕЛЯЮЩИЕ ИЗМЕНЧИВОСТЬ АМИНОКИСЛОТНЫХ ПОСЛЕДОВАТЕЛЬНОСТЕЙ CYTB АЗИАТСКИХ СКАЛЬНЫХ ПОЛЕВОК (ALTICOLA, RODENTIA, ARVICOLINAE)
Authors: КОВАЛЕВА В.Ю. , МОРОЛДОЕВ И.В. , ЛИТВИНОВ Ю.Н. , ЕФИМОВ К.В. , ЕФИМОВ В.М. 
Published: January 2025

Проведен статистический анализ изменчивости аминокислотного состава митохондриального белка CYTBазиатских скальных полевок р. Alticola. Последовательности (N = 36; 380 а. о.) взяты из GenBankвместе c сопутствующей информацией об их географической принадлежности. Вычислены частоты аминокислот для каждой последовательности и матрица квадратов евклидовых расстояний между ними, по которой методом главных координат рассчитаны главные компоненты (principal component - PC). В пространстве первых двух PC (Σλ = 76,89 %) все последовательности группируются в соответствии с их видовой принадлежностью, образуя восточно-сибирскую (A. strelzowi, A. olchonensis, A. semicanus, A. tuvinicus), южную (A. stracheyi, A. argentatus, A. albicaudus, A. stoliczkanus, A. barakshin) и северо-восточную (A. lemminus, A. macrotis) группы. В направлении PC1 происходит изменение частот Met, Gly, Ile → Ala, Thr, компонента высоко коррелирует с большим подмножеством AA-индексов (N= 362 при p-value <0,01 с учетом множественных сравнений по Бонферрони) и средним эволюционным рангом последовательностей CYTB. В направлении PC2 изменяются частоты Val, Phe → Leu. Это направление демонстрирует значимые корреляции с широтой ( r = 752; p < 0,001), высотой ( r = -717; p < 0,01) местности, 21 климатической переменной местообитаний полевок и 54 AA-индексами.
A statistical analysis of the variability in the amino acid composition of the mitochondrial protein CYTB of Asian mountain voles of the genus Alticola was carried out. Sequences (N = 36; 380 a. a.) were taken from GenBank along with accompanying information about their geographical location. The frequencies of amino acids for each sequence and the matrix of squared Euclidean distances between them were calculated, from which the principal components (PC) were calculated using the principal coordinate method. In the space of the first two PCs (Σλ = 76.89 %), all sequences are grouped according to their species, forming the East Siberian (A. strelzowi, A. olchonensis, A. semicanus, A. tuvinicus), southern (A. stracheyi, A. argentatus, A. albicaudus, A. stoliczkanus, A. barakshin) and the northeastern group (A. lemminus, A. macrotis). Mutational pressure in the PC1 direction leads to a change in the frequencies of Met, Gly, Ile → Ala, Thr, which strongly correlates with a large subset of AA indices and the average evolutionary rank of CYTB sequences (N = 362 with p -value < 0.01 taking into account multiple comparisons according to Bonferroni). In the PC2 direction, the frequencies Val, Phe → Leu change. This direction reveals significant correlations with latitude, altitude, 21 climatic variables of vole habitats and 54 AA indices.
The Interaction Between Critical Thinking, Education and Belief in Conspiracy Theories among Young People (Aged 25–30)
Authors: Butvilauskaitė Gintarė , Mikuličiūtė Vita 
Published: January 2025

The goal of educational institutions (especially universities) is to foster critical thinking. However, with the rising popularity of social media and the rapid spread of unchecked information there, more and more people, especially young ones, are inclined to believe in conspiracy theories. This raises the question of whether university students are truly being taught critical thinking skills that would help combat misinformation. Therefore, this study attempts to analyze the interaction between education, critical thinking, and belief in conspiracy theories among young people (aged 25–30). The study involved 73 participants (M = 26.9; SD = 1.7). 36 have a university education (bachelor’s or master’s degree), 37 a nonuniversity education (secondary, secondary with professional qualification, or nonuniversity bachelor’s degree). Participants were provided with instruments to determine their level of belief in conspiracy theories and their critical thinking. The results show that critical thinking fully mediates the relationship between education and belief in conspiracy theories. Additionally, individuals with a university education have a higher level of critical thinking and are less likely to believe in conspiracy theories compared to those without a university education. Finally, a significant negative correlation was found between the critical thinking of young people and their belief in conspiracy theories.
ФІСКАЛЬНА ПОЛІТИКА СУЧАСНОГО КИТАЮ: ГЛОБАЛЬНІ ТА ЛОКАЛЬНІ ВИКЛИКИ
Authors: СТЕПАНОВА Олена , ДЕГТЯРЬ Наталія 
Published: January 2025

Фіскальну політику сучасного Китаю спрямовано на підтримку зміни типу «економічне зростання високих темпів» на «економічне зростання високої якості», що передбачає формування нових виробничих сил. Однак посилення геоекономічної фрагментації, декаплінг економіки Китаю і США, демографічний перехід і зростання боргового навантаження стають викликами резильєнтності публічних фінансів країни.
Визначено особливості й заходи сучасної фіскальної політики Китаю в умовах загострення глобальної економічної конфронтації, аргументовано необхідність проведення фіскального коригування для подолання внутрішніх макроекономічних і фіскальних дисбалансів. Проведено аналіз динаміки і структури надходжень і витрат бюджетів різних рівнів КНР протягом останнього десятиріччя, визначено чинники їх зміни; систематизовано й здійснено аналітичну оцінку факторів впливу на сучасний стан публічних фінансів КНР. Показано, що виклики виробничої дезінтеграції і макроекономічні дисбаланси обумовлюють тиск на надходження до бюджетів різних рівнів.
Демографічні виклики, спричинені зростанням довголіття населення Китаю, зменшенням народжуваності й старінням населення, тиснуть на державні витрати і зумовлюватимуть їх зростання в середньостроковій перспективі. Вагомим викликом стійкості публічних фінансів Китаю стає збільшення місцевого боргу, в тому числі через зростання неявних боргів місцевих фінансових механізмів. Для стимулювання «економічного зростання високої якості» в Китаї вжито заходів податкового навантаження на суб’єктів господарювання. Розширення фіскального простору здійснюється шляхом випуску спеціальних довгострокових облігацій, доходи від яких направлятимуться на фінансування проєктів, у тому числі у сфері високотехнологічного виробництва. Зроблено висновки, що фіскальна політика Китаю адаптується до нової економічної реальності й забезпечує формування нового типу економічного зростання. Проте пошук балансу між стимулюванням подальшого зростання китайської економіки в умовах глобальних і локальних викликів і підтримкою фіскальної стійкості стає основним завданням фіскальної політики Китаю на майбутнє.
Comparing Midline and Peripherally Inserted Central Catheters: A Randomized Feasibility Trial
Authors: Burek Alina G. , Porada Kelsey , Plunk Matthew R. , Corey Bauer Sarah , Liegl Melodee , Pan Amy , Flynn Kathryn E. , Brousseau David C. , Gedeit Reiner , Ullman Amanda J. 
Published: January 2025

OBJECTIVES
The most effective use of midline catheters in children is not understood. We aimed to (1) test the feasibility of a trial comparing peripherally inserted central catheters (PICCs) to midline catheters in hospitalized children in need of durable vascular access and (2) collect preliminary effectiveness data of the 2 devices.

METHODS
Our study combined a single site, randomized controlled feasibility trial (RCT, primary study) and a prospective observational study (alternative study) comparing PICCs to midline catheters. Hospitalized children aged 2 to 17 years in need of noncentral, medium-term vascular access (5–14 days) were enrolled for 1 year. The primary outcome of the RCT was a 4-measure feasibility outcome, and we had an enrollment goal of 30 participants/arm. Effectiveness outcomes (both studies) included time-to-device removal and all-cause failure.

RESULTS
Between August 2022 and August 2023, only 43 of 260 screened patients met eligibility criteria because of a decrease in eligible PICCs. A total of 35 patients were enrolled: 8 out of 10 in the RCT (4/arm) and 27 out of 33 in the alternative study (21 midline catheters, 6 PICCs). The RCT eligibility goal was not met. The other feasibility measures were met: (1) 80% of eligible patients enrolled, (2) 100% of eligible patients received the assigned intervention, (3) 96% of inserters found the study acceptable, and (4) there were no missing data.

CONCLUSIONS
Because of a decrease in PICC use for noncentral, medium-term vascular access needs, a trial comparing devices may not be practical for assessing the effective use of midline catheters in hospitalized children. Next steps may include a hybrid effectiveness-implementation study evaluating an intravenous catheter selection algorithm that incorporates midline catheters.
Czy Henryk Bitterfeld napisał dla królowej Jadwigi „Żywot świętej Jadwigi Śląskiej”? (Dominikanie na dworze Jadwigi Andegaweńskiej)
Authors: Turek Jakub 
Published: January 2025

W artykule została omówiona kwestia autorstwa Henryka Bitterfelda rzekomego „Żywota św. Jadwigi”. Dzieło o takim tytule było wymieniane w kolejnych katalogach prac dominikanina, choć jego tekst nie jest znany. Przeprowadzona w artykule analiza wykazała, że nie ma żadnych przesłanek pozwalających łączyć Bitterfelda ze wspominanym utworem. W jego dorobku nie ma innych hagiografii. Postać św. Jadwigi Śląskiej nie wpisuje się także w model hagiograficzny promowany przez bliskich Bitterfeldowi obserwantów. Chybione są również próby łączenia „Żywota św. Jadwigi” ze śląskim pochodzeniem jego domniemanego autora. Ponadto w momencie, gdy Bitterfeld przybył do polskiej prowincji Zakonu Kaznodziejów, władzę przejęli bracia z Małopolski, którzy w obliczu wieloletniej rywalizacji ze Ślązakami nie byli zainteresowani promowaniem kultu świętej z tej dzielnicy. Także wzmianki na temat „Żywota św. Jadwigi” są bardzo późne. Najstarsza z nich pochodzi dopiero z XVIII wieku.
Total Physical Response (TPR) y el desarrollo de la metacognición y la motivación en el aprendizaje del inglés
Authors: Molina Gómez Doris , Orozco Lambraño Yesenia , Piñerez Castro Eliberto , Eduar Mejia Elquin , Conejo Carrasco Francisco 
Published: January 2025

Este es un estudio cualitativo con alcance exploratorio ya que quiso examinar una temática de investigación poco estudiada sobre la enseñanza y aprendizaje del inglés, tuvo como objetivo establecer la relación entre el método TPR (Total Physical Response) y el desarrollo motivacional y metacognitivo en estudiantes de grado séptimo del área de inglés de tres instituciones de educación básica del sector rural y urbano en Colombia.
Para esto se usó una muestra de tipo no probabilística intencional ya que en estos grupos se evidenció mayor dificultad en el aprendizaje y uso de la segunda lengua, mayor temor al expresarse oralmente e interactuar con el otro, a esta población se les aplicó como instrumento una encuesta, que permitió conocer la efectividad del método TPR para el aprendizaje significativo del inglés.
Como metodología de análisis se usó la descripción y comparación, se utilizó una matriz de Excel, estructurada, categorizada y detallada con objetivos específicos, categorías, subcategorías y hallazgos, que permitió comparar y analizar cada dato obtenido y ver los resultados con claridad.
Los resultados arrojaron que el método logró despertar el interés y la motivación permitiendo un aprendizaje significativo del inglés, de manera autónoma y autorregulada, facilitando la participación activa del estudiante.