bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eribulin combined with antiangiogenic agents in women with HER2-negative metastatic breast cancer: a retrospective multicenter study
Authors: Jiang Mingxia , Shao Bin , Wan Donggui , Liu Jiaxuan , He Maiyue , Chai Yue , Sang Die , Wang Jiayu , Ma Fei , Fan Ying , Yuan Peng , Xu Binghe , Li Qiao 
Published: October 2023

Background: The relative lack of specifically targeted agents for HER2-negative metastatic breast cancer (MBC) makes the need for new agents or combination therapies to maximize clinical benefit while reducing toxicity critical. Objectives: To retrospectively analyze the efficacy and safety of eribulin combined with antiangiogenic drugs in the treatment of Chinese women with HER2-negative MBC. Methods: A total of 85 consecutive MBC patients with HER2-negative who were treated with eribulin + antiangiogenic agents between October 2020 and April 2023 in four institutions were retrospectively included in this study. Patients received eribulin 1.4 mg/m2 (day 1 and 8) plus bevacizumab 7.5 mg/kg (day 1, 64 patients) or anlotinib 10 mg daily (day 1–14, 16 patients) or apatinib 250 mg daily (5 patients) on a 21-day cycle until progression or unacceptable toxicity. The primary end-point was progression-free survival (PFS), according to Response Evaluation Criteria in Solid tumors (RECIST) 1.1. Secondary end-points included toxicities, objective response rate (ORR), disease control rate (DCR), and overall survival (OS). Adverse events (AEs) were graded according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Results: The study included 85 HER2-negative MBC patients, with 41 patients (48.2%) in the first to second line group and 44 patients (51.8%) in the greater than or equal to third line group. The median age was 54.0 years. Thirty patients in the first to second line group and 14 patients in the greater than or equal to third line group had triple-negative breast cancer (TNBC). The ORR and DCR were 34.1% (29/85) and 75.3% (64/85). The median PFS (mPFS) of total population was 6.0 months (95% CI: 4.3–7.7), and median OS (mOS) was immature. The mPFS was 7.7 and 4.3 months in the first to second and greater than or equal to third line treatment ( p = 0.003), respectively. TNBC patients in first to second line therapy showed a significantly longer PFS (6.5 months versus 2.0 months, p = 0.021) compared to greater than or equal to third line. The incidences of cardiovascular toxicity were 29.4% in grades 1–2 and no grades 3–4. Hematologic toxicity (leukopenia and neutropenia) was the most common grade ⩾3 AEs, and AEs were more common in patients in greater than or equal to third line. Conclusion: The results suggest that eribulin combined with antiangiogenic therapy has a meaningful clinical activity and an acceptable safety profile in HER2-negative MBC.
Return to work following brachial plexus injury: A cross-sectional study
Authors: Brown Hazel , Kennard Kate , Tyreman Rosalyn , Alim-Marvasti Ali , Wilcox Matthew , Quick Tom 
Published: October 2023

Background Qualitative studies following Brachial Plexus Injury (BPI) suggest that return to employment has a major influence on life satisfaction and psychological well-being. However, few studies have focused on return to work following BPI. The physical strain and intensity of an occupation may influence the ability of an individual to return to employment. This study aimed to provide information about the impact of workload intensity on employment status following BPI. Methods This is an observational, retrospective study of 74 participants who responded to a postal questionnaire, sharing information regarding their employment status pre- and post-BPI. The reported occupations were assessed for workload intensity and assigned a Reichsausschuss für Arbeitszeitermittlung (REFA) classification by two assessors. Results Forty-one out of 74 participants (57%) had to change their employment following their BPI. Changes in occupation were more likely if the pre-injury REFA score was 3 or 4 ( n = 22). In the Complete plexus injury group ( n = 8), 100% changed occupation. In the Partial plexus injury group ( n = 66) 50% changed occupation. Hand dominance had no significant influence on change of employment ( p = 0.37). Conclusion This study is the first to focus on the impact of BPI on employment status and workload intensity. Just over half the participants did not maintain the same employment following their BPI and one in five became unemployed. Future research should review the factors that contribute to the inability to return to work. This may direct enhancements in rehabilitation provision and enable healthcare services to focus on facilitating individuals back to the workplace.
Assessing the Psychometric Validity of the Epistaxis Severity Score: Internal Consistency and Test–Retest Reliability
Authors: Gong Anna J. , Bolsegui Marisabel Linares , Lee Emerson E. , Mathai Stephen C. , Weiss Clifford R. 
Published: October 2023

Background The Epistaxis Severity Score (ESS) is the gold-standard patient-reported outcome measure for evaluating nosebleed severity in patients with hereditary hemorrhagic telangiectasia (HHT). To date, the ESS has been assessed only for content validity and concurrent validity. Objective We evaluate the internal consistency and test–retest reliability of the ESS. Materials and Methods After receiving institutional review board approval, we sent an online survey battery, including the ESS survey, to 305 (39% male) English-speaking HHT patients ≥18 years old at a single center. Of those, 140 (46%) patients completed the battery, and 110/140 (79%) reported epistaxis. Cronbach's alpha and correlation analyses were used to evaluate internal consistency. For the test–retest reliability evaluation, we recruited 69 HHT patients during HHT clinic to complete 2 self-administered ESS surveys 2 weeks apart. Participants also completed a modified Clinical Global Impression-Improvement scale with readministration of the ESS survey. We calculated the intraclass correlation coefficient in a 2-way mixed model with absolute agreement. Results The ESS survey demonstrated low internal consistency (Cronbach's alpha = 0.495), suggesting that it measured multiple unrelated concepts. Factor analysis revealed 3 latent factors with moderate intercorrelation, suggesting the presence of 3 related but distinct constructs underlying the ESS. However, the ESS demonstrated excellent test–retest reliability (intraclass correlation coefficient = 0.955; 95% CI, 0.91-0.98). Conclusion Although the ESS demonstrates high test–retest reliability, it may not adequately assess different dimensions of nosebleed severity. Additional correlated survey questions and sub-scores may be needed to increase internal consistency to accurately measure each component of epistaxis severity. It is necessary to acknowledge epistaxis severity from different dimensions and to consider evaluating individual ESS items separately for a comprehensive understanding.
Online health community—An empirical analysis based on grounded theory and entropy weight TOPSIS method to evaluate the service quality
Authors: Hua Yang , Shujuan Wang , Fucheng Wang 
Published: October 2023

Introduction With the enhancement of people's health awareness and the impact of the coronavirus pandemic in recent years, people's demand for online health information continues to expand, and online health communities (OHCs) have developed rapidly. However, the service quality of OHCs is uneven, and problems such as content quality, privacy disclosure are increasingly prominent. It's of great significance to establish normalized OHC service quality evaluation standards and develop effective evaluation tools and methods for the improvement of OHC service quality. Material and Methods Based on the grounded theory, the raw materials obtained from semi-structured interviews were coded in three stages to construct a service quality evaluation system for OHC. Through empirical analysis, the rationality and effectiveness of the evaluation system were verified. Then six representative Chinese OHCs were selected and their service quality was evaluated by the entropy weight TOPSIS method. Results The service quality evaluation system of OHC was constructed which includes 4 first-level indicators and 16 second-level indicators. The weights of the first-level indicators from large to small are content quality, emotional experience quality, interaction quality and function quality. Among the second-level indicator weights, the top three are perceived cost reasonableness, content professionalism and effectiveness of interactive content. Conclusions The indicator system is reasonable and effective and the evaluation method has strong applicability and operability. This study will provide theoretical guidance for community platform operators and relevant departments to design effective evaluation mechanism of OHC service quality, offering a reference for decisions and policymakers.
Mapping inpatient care pathways for patients with COPD: an observational study using routinely collected electronic hospital record data
Authors: Evison Felicity , Cooper Rachel , Gallier Suzy , Missier Paolo , Sayer Avan A. , Sapey Elizabeth , Witham Miles D. 
Published: October 2023

IntroductionRespiratory specialist ward care is associated with better outcomes for patients with COPD exacerbations. We assessed patient pathways and associated factors for people admitted to hospital with COPD exacerbations.MethodsWe analysed routinely collected electronic health data for patients admitted with COPD exacerbation in 2018 to Queen Elizabeth Hospital, Birmingham, UK. We extracted data on demographics, deprivation index, Elixhauser comorbidities, ward moves, length of stay, and in-hospital and 1-year mortality. We compared care pathways with recommended care pathways (transition from initial assessment area to respiratory wards or discharge). We used Markov state transition models to derive probabilities of following recommended pathways for patient subgroups.ResultsOf 42 555 patients with unplanned admissions during 2018, 571 patients were admitted at least once with an exacerbation of COPD. The mean±sdage was 51±11 years; 313 (55%) were women, 337 (59%) lived in the most deprived neighbourhoods and 45 (9%) were from non-white ethnic backgrounds. 428 (75.0%) had ≥4 comorbidities. Age >70 years was associated with higher in-hospital and 1-year mortality, more places of care (wards) and longer length of stay; having ≥4 comorbidities was associated with higher mortality and longer length of stay. Older age was associated with a significantly lower probability of following a recommended pathway (>70 years: 0.514, 95% CI 0.458–0.571; ≤70 years: 0.636, 95% CI 0.572–0.696; p=0.004).ConclusionsOnly older age was associated with a lower chance of following recommended hospital pathways of care. Such analyses could help refine appropriate care pathways for patients with COPD exacerbations.
Research progress on multiple cell death pathways of podocytes in diabetic kidney disease
Authors: Yang Can , Zhang Zhen , Liu Jieting , Chen Peijian , Li Jialing , Shu Haiying , Chu Yanhui , Li Luxin 
Published: October 2023

AbstractDiabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal failure. The injury and death of glomerular podocytes are the keys to DKD. Currently, a variety of cell death modes have been identified in podocytes, including apoptosis, autophagy, endoplasmic reticulum (ER) stress, pyroptosis, necroptosis, ferroptosis, mitotic catastrophe, etc. The signaling pathways leading to these cell death processes are interconnected and can be activated simultaneously or in parallel. They are essential for cell survival and death that determine the fate of cells. With the deepening of the research on the mechanism of cell death, more and more researchers have devoted their attention to the underlying pathologic research and the drug therapy research of DKD. In this paper, we discussed the podocyte physiologic role and DKD processes. We also provide an overview of the types and specific mechanisms involved in each type of cell death in DKD, as well as related targeted therapy methods and drugs are reviewed. In the last part we discuss the complexity and potential crosstalk between various modes of cell death, which will help improve the understanding of podocyte death and lay a foundation for new and ideal targeted therapy strategies for DKD treatment in the future.
On Energy Assessment of Titanium Alloys Belt Grinding Involving Abrasive Wear Effects
Authors: Li Mingcong , Zhao Shudong , Li Heng , Huang Yun , Zou Lai , Wang Wenxi 
Published: October 2023

AbstractImproved energy utilisation, precision, and quality are critical in the current trend of low-carbon green manufacturing. In this study, three abrasive belts were prepared at various wear stages and characterised quantitatively. The effects of abrasive belt wear on the specific grinding energy partition were investigated by evaluating robotic belt grinding of titanium plates. A specific grinding energy model based on subdivided tangential forces of cutting and sliding was developed for investigating specific energy and energy utilisation coefficient EUC. The surface morphology and Abbott–Firestone curves of the belts were introduced to analyse the experimental findings from the perspective of the micro cutting behaviour. The specific grinding energy increased with abrasive belt wear, especially when the belt was near the end of its life. Moreover, the belt wear could lead to a predominance change of sliding and chip formation energy. The highest EUC was observed in the middle of the belt life because of its retained sharp cutting edge and uniform distribution of the grit protrusion height. This study provides guidance for balancing the energy consumption and energy utilization efficiency of belt grinding.
Out-of-hospital cardiac arrest treated with prehospital double sequential external defibrillation during eCPR in refractory VF — a case report
Authors: Katzenschlager Stephan , Heck Raphael , Popp Erik , Weilbacher Frank , Weigand Markus A. , Eisner Christoph , Neuhaus Christopher 
Published: October 2023

Abstract
Background
Double sequential external defibrillation (DSED) has demonstrated increased survival with good neurological outcome in a recent randomized controlled trial. DSED has not been studied in patients with extracorporeal cardiopulmonary resuscitation (eCPR).

Case
We present the first case of prehospital eCPR with ongoing refractory ventricular fibrillation (VF), terminated by DSED. After six shocks, return of spontaneous circulation was initially achieved; however, the patient went into recurrent VF. ECPR was performed prehospital, with VF still refractory after three more shocks. DSED successfully terminated VF and showed a further increase in etCO2 and near-infrared spectroscopy cerebral oximetry values.

Conclusion
DSED can be a sufficient strategy for patients in refractory VF while on eCPR and should be evaluated in further studies.
Comparison of the efficacy of BCG intravesical immunotherapy using the conventional Rotisserie method with the non-Rotisserie method
Authors: Hariri Mohammad Kazem , Rajabalian Mohammad-Bagher , Narouie Behzad , rohollahpour Saeed , Rostami Ghasem , Ahmadzade Mohadese 
Published: October 2023

Abstract
Background
Intravesical BCG injections are administered following transurethral resection of the superficial bladder tumor in order to increase the success rate and decrease the risk of tumor recurrence. BCG therapy has been examined extensively in terms of dosage and injection time intervals to determine its effectiveness. However, no study has yet been conducted to compare the two qualitatively different methods of administering BCG (Rotisserie and non-Rotisserie).

Methods
This study included 30 patients with non-muscle-invasive bladder TCC, whose tumor stage was Ta or T1. Two groups of 15 patients were randomly selected. The first intravesical injection of BCG was administered 2 weeks following transurethral resection of the bladder tumor and then continued as the maintenance treatment. But, in one group, the injection was done by Rotisserie method, and in the other group, non-Rotisserie method was performed. Then, the patients underwent periodic follow-up by cystoscopy to determine if recurrences had occurred.

Results
A total of 23 participants (76.66%) were males, while seven patients (23.34%) were females. There were 20 participants (66.66%) with tumors in the Ta stage and ten participants (33.34%) with tumors in the T1 stage. There were 22 patients (73.3%) with low-grade tumors and eight (26.7%) with high-grade tumors. Five participants (16.66%) experienced tumor recurrence during the study, three of whom were in the Rotisserie group and two in the Non-Rotisserie group. In terms of preventing tumor recurrence, there were no significant differences between Rotisserie and non-Rotisserie methods (P value = 0.6).

Conclusion
Due to the lack of significant difference in the rate of tumor recurrence between the two methods of intravesical BCG injection (Rotisserie and non-Rotisserie), it is not necessary to rotate the patients after BCG injection. This will also allow patients to be discharged from the hospital earlier and reduce the likelihood of complications.
Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study
Authors: Ito Hiroshi , Ibaraki Masanobu , Yamakuni Ryo , Hakozaki Motoharu , Ukon Naoyuki , Ishii Shiro , Fukushima Kenji , Kubo Hitoshi , Takahashi Kazuhiro 
Published: October 2023

AbstractThe regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. The cerebral blood flow (CBF), cerebral blood volume (CBV), OEF, and cerebral metabolic rate of oxygen (CMRO2) were measured on healthy men by PET with 15O-labeled gases. The OEF values in the pons and the parahippocampal gyrus were significantly smaller than in the other brain regions. The OEF value in the lateral side of the occipital cortex was largest among the cerebral cortical regions. Simulation studies have revealed that errors in OEF caused by regional differences in the distribution volume of 15O-labeled water, as well as errors in OEF caused by a mixture of gray and white matter, must be negligible. The regional differences in OEF in brain must exist which might be related to physiological meanings.Article title: Kindly check and confirm the edit made in the article title.I have checked the article title and it is OK as is.
Trial registration: The UMIN clinical trial number: UMIN000033382, https://www.umin.ac.jp/ctr/index.htm
Sequence-based GWAS meta-analyses for beef production traits
Authors: Sanchez Marie-Pierre , Tribout Thierry , Kadri Naveen K. , Chitneedi Praveen K. , Maak Steffen , Hozé Chris , Boussaha Mekki , Croiseau Pascal , Philippe Romain , Spengeler Mirjam , Kühn Christa , Wang Yining , Li Changxi , Plastow Graham , Pausch Hubert , Boichard Didier 
Published: October 2023

Abstract
Background
Combining the results of within-population genome-wide association studies (GWAS) based on whole-genome sequences into a single meta-analysis (MA) is an accurate and powerful method for identifying variants associated with complex traits. As part of the H2020 BovReg project, we performed sequence-level MA for beef production traits. Five partners from France, Switzerland, Germany, and Canada contributed summary statistics from sequence-based GWAS conducted with 54,782 animals from 15 purebred or crossbred populations. We combined the summary statistics for four growth, nine morphology, and 15 carcass traits into 16 MA, using both fixed effects and z-score methods.

Results
The fixed-effects method was generally more informative to provide indication on potentially causal variants, although we combined substantially different traits in each MA. In comparison with within-population GWAS, this approach highlighted (i) a larger number of quantitative trait loci (QTL), (ii) QTL more frequently located in genomic regions known for their effects on growth and meat/carcass traits, (iii) a smaller number of genomic variants within the QTL, and (iv) candidate variants that were more frequently located in genes. MA pinpointed variants in genes, including MSTN, LCORL, and PLAG1 that have been previously associated with morphology and carcass traits. We also identified dozens of other variants located in genes associated with growth and carcass traits, or with a function that may be related to meat production (e.g., HS6ST1, HERC2, WDR75, COL3A1, SLIT2, MED28, and ANKAR). Some of these variants overlapped with expression or splicing QTL reported in the cattle Genotype-Tissue Expression atlas (CattleGTEx) and could therefore regulate gene expression.

Conclusions
By identifying candidate genes and potential causal variants associated with beef production traits in cattle, MA demonstrates great potential for investigating the biological mechanisms underlying these traits. As a complement to within-population GWAS, this approach can provide deeper insights into the genetic architecture of complex traits in beef cattle.
Starvation induces hepatopancreas atrophy in Chinese mitten crab (Eriocheir sinensis) by inhibiting angiogenesis
Authors: Liu Hongli , Feng Yang , Yang Ma , Huang Ya , Li Minghao , Geng Yi , Ouyang Ping , Chen Defang , Yang Shiyong , Yin Lizi , Li Liangyu , Huang Xiaoli 
Published: October 2023

Abstract
Background
The hepatopancreas of crustaceans serves as a significant organ for both the synthesis and secretion of digestive enzymes, as well as energy storage. In the event of food shortage, the hepatopancreas can provide energy for survival. To investigate the potential regulatory mechanisms of the hepatopancreas in response to starvation in Eriocheir Sinensis, transcriptome analysis, histological study and qRT-PCR were performed.

Results
The results showed that starvation caused a decrease in the hepatopancreas index of E. sinensis, which had certain effects on the tissue structure, metabolism and angiogenesis in the hepatopancreas. In addition, WGCNA and linear regression analysis showed that the genes significantly related to the hepatopancreas index were mainly enriched in the angiogenesis pathway, in which AKT signaling played an important role. Starvation may inhibit AKT signaling pathway by reducing the expression of TGFBI, HSP27, HHEX, and EsPVF1, thereby hindering angiogenesis, promoting apoptosis, and leading to hepatopancreas atrophy.

Conclusion
These results indicate that AKT plays an important role in the angiogenesis pathway and apoptosis of the starvation induced hepatopancreas index reduction, which is beneficial to further understand the effect of starvation stress on hepatopancreas of Chinese mitten crab.