bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gingival Debulking Surgery for a Child With Severe Aplastic Anemia: A Case Report
Authors: Hurley Caitlin R. , Winters John , McAlpine Melanie , Ng Michelle , Anthonappa Robert P. 
Published: January 2025

ABSTRACTIntroductionAplastic anemia (AA) is a rare condition that frequently manifests with pancytopenia. Management of severe disease is through either allogenic stem cell transplantation or immunosuppressive therapy with supportive care. Drug‐induced gingival overgrowth (DIGO) is a potential complication of a number of medications, including cyclosporine and amlodipine.Case ReportThe following report presents the case of a male child who was diagnosed with severe AA at 7 years of age. He was managed with immunosuppressive therapy and developed DIGO as a side effect of treatment, exacerbated by poor oral hygiene. Nonsurgical and surgical management strategies were utilized. Gingival debulking surgery was completed at 9 years of age, once the patient's condition had stabilized. Postoperative care included regular dental prophylaxis and oral hygiene instruction. The patient's medical condition remained stable, and his oral health was maintained without relapse of DIGO.ConclusionThis case emphasizes the importance of coordinated care for managing DIGO in immunocompromised pediatric patients and describes the successful management of DIGO using both nonsurgical and surgical methods.
Breaking the glass ceiling: Statistical evidence of the gender effect in higher education leadership
Authors: Wu Allison 
Published: January 2025

AbstractThis study aims to explore the influence of female presidential leadership (gender effect) on the overall performance of universities in the United States. To achieve this research objective, data on the gender of university presidents from 1983 to 2022 were manually collected from 129 top universities in the USA. Using this dataset, a sample comprising two groups was constructed: a treatment group consisting of male‐to‐female presidential transitions and a control group comprising male‐to‐male presidential transitions. The hypothesis was tested through a difference‐in‐differences approach. The results of the study were also validated using parallel trend analysis. The results suggest that female presidents have a significant positive impact on university rankings. This means that female leadership is associated with improvements in university rankings, highlighting their potential contribution to the advancement of educational institutions and pursuit of excellence through policy decisions and leadership. Moreover, the difference‐in‐differences analysis results reveal that universities under the leadership of female presidents achieve higher rankings than those with male presidents, especially after presidential transitions. Thus, this study provides the first statistical evidence that female educators are more effective leaders in terms of university performance than their male counterparts.
Financial literacy for individuals with intellectual and developmental disabilities: Border crossing required
Authors: Kang Sungwoo , Kastberg Signe , Mason Benjamin 
Published: January 2025

AbstractIn the evolving landscape of financial literacy in education, this study aims to describe methodologies used in mathematics and special education research, specifically targeting individuals with intellectual and developmental disabilities (IDD). Based on a systematic review of research studies that addressed financial literacy for students with IDD, we analyzed definitions of financial literacy, educational objectives, and the differing strategies employed to meet those objectives and aligned target domains in financial literacy using Bloom's taxonomy. Our investigation reveals disciplinary differences in definitions, objectives, and strategies in studies from mathematics and special education. Mathematics education research encourages contextual problem‐solving, urging students to apply learned knowledge to practical situations, thereby facilitating advanced financial decision‐making skills. In a complementary view, special education research tends to focus on skill acquisition and maintenance that support student performance of essential financial tasks (identifying coins and their value). Both disciplines aim to enhance students' financial literacy, catering to the complex needs of individuals with IDD. This analysis underscores the need for an integrated approach to reinforce financial literacy and to promote more independent and community‐involved experiences for individuals with IDD.
Playing With Perceptions: Investigating Bias in Soccer Through Skin Tone Manipulation
Authors: Nesseler Cornel , Gasparetto Thadeu , Naidenova Iuliia , Parshakov Petr 
Published: January 2025

ABSTRACTObjectiveThis study aims to investigate implicit discrimination in soccer by examining whether participants’ evaluations of fouls are influenced by players’ skin color.MethodsAn optimal experimental design was developed where players’ skin color in soccer videos was artificially altered. Participants were asked to choose the most appropriate penalty for a player committing a foul. The data were analyzed using ordered logit regressions to assess whether skin color influenced the penalties assigned.ResultsContrary to previous research and popular belief, the results show that participants’ penalty decisions were not significantly influenced by the players’ skin color.ConclusionsThe findings suggest that implicit discrimination may not be present in this context, challenging previous studies that found racial biases in sports. The experimental design and results lay the groundwork for further research into implicit bias in sports contexts.
Retrobulbar Infiltrative Lipoma in a Dog
Authors: Presley Trace , Sasaki Emi , de Cecco Bianca S. , Carter Renee T. , St. Blanc Alissa , Rademacher Nathalie , Camacho‐Luna Pilar 
Published: January 2025

ABSTRACTA 6‐year‐old castrated male mixed breed dog presented to the “Louisiana State University Veterinary Teaching Hospital &‐anonymized for review” ophthalmology service with marked exophthalmos and lagophthalmos of the left eye and soft tissue swelling medial to the zygomatic arch. A computed tomography (CT) scan was performed, and it revealed a well‐marginated, lobulated, homogenously fat density involving the retrobulbar space. Preliminary results of a fine‐needle aspirate (FNA) and biopsy were not conclusive, and a modified transfrontal orbitotomy was performed to remove the mass. Histopathological evaluation was diagnostic for retrobulbar infiltrative lipoma. Nine months after the surgery, the eye appears within normal limits with no evidence of recurrence.
Physiology of bridging stent grafts after fenestrated/branched endovascular aortic repair: Where translational science meets the clinical profile
Authors: Moothathamby Thurkga , Jubouri Matti , Rajasekar Tharun , Roy Subham , Alfwaress Maya , Rezk Samuel S. S. , Ghattas Samuel N. S. , D'Oria Mario , Bailey Damian M. , Williams Ian M. , Bashir Mohamad 
Published: January 2025

AbstractFenestrated/branched endovascular aortic repair emerges as the primary therapeutic modality for intricate aortic pathologies encompassing the paravisceral and thoracoabdominal segments, where bridging stent grafts (BSGs) play a vital role in linking the primary aortic endograft with target vessels. Bridging stent grafts can be categorized mainly into self‐expanding stent grafts (SESGs) and balloon‐expandable stent grafts (BESGs). Physiological factors significantly influence post‐complex endovascular aortic repair BSG behaviour, impacting clinical outcomes of SESGs and BESGs in different but overlapping ways. Crucial prerequisites for BSGs encompass not only flexibility but also resilience against mechanical stress and compliance mismatch, especially when bridging the rigid aortic main body with dynamic target vessels. The significance of considering these physiological factors in clinical decision‐making is underscored by recognizing the interplay between SESG and BESG characteristics, vessel physiology and patient haemorheology. Such factors include the anatomy and tortuosity of the vessel, diameter of the vessel and BSG, deployment and durability, extrinsic stenosis and respiratory motion. Haemorheological factors, such as anti‐thrombotic therapy and hydration status, need to be considered. This narrative review examines both in vitro and in vivo evidence regarding the impact of physiological factors on the behaviour of BSGs and assesses the consequences for clinical outcomes following complex endovascular aortic repair.
A Brayton Pumped Thermal Energy Storage System Based on Supercritical Carbon Dioxide Recompression Reheating Discharge Cycle
Authors: You Dongchuan , Tatli Akif Eren , Metghalchi Hameed 
Published: January 2025

Abstract
In recent years, renewable energy such as solar energy and large-scale energy storage, which is a very important technology to compensate for solar energy's fluctuation due to weather issues, have been extensively investigated. In this paper, a Pumped Thermal Energy Storage (PTES) cycle based on a supercritical carbon dioxide (sCO2) Recompression Reheating cycle and energy pump with a recuperator has been proposed and analyzed. Molten salt with varying temperatures of 565 °C to 730 °C has been used for energy storage. The pressure ratios have been fixed in the discharge cycle as 2.5, and in the charging cycle, it varies in order to find the optimum operation condition. Parametric studies have been made to determine the best performance of the new system. Molten salt temperature, split ratio, pressure ratio, and intermediate pressure have been varied in the calculation. Exergy analysis has been developed in order to determine exergy destruction in all components. Roundtrip efficiencies have been calculated over a wide range of operating conditions. Different working fluids such as argon, carbon dioxide, and nitrogen were used in both cycles. Performance was determined for different combinations of working fluids. It is concluded that for best performance working fluid for energy pump (charging) should be argon and carbon dioxide should be the working fluid for discharging cycle. For this combination operating at optimum molten salt temperature, intermediate pressure and split ratio in the discharging cycle, the roundtrip efficiency is 66%, which is the maximum.
A Design for Remanufacturing Framework Incorporating Identification, Evaluation, and Validation: A Case Study of Hydraulic Manifold
Authors: Liu Xinyang , Chung In-Bum , Behtash Mohammad , Davied Matthew , Thompson Todd , Lopez Richard , Lee Michael , Bishop William , Wang Pingfeng , Hu Chao 
Published: January 2025

Abstract
In recent years, academic researchers and engineers in the industry have widely recognized the necessity of integrating remanufacturing considerations into product design iterations to advance sustainability objectives. Acknowledging the importance of design for remanufacturing (DfRem), efforts were made to develop tools and guidelines that could be implemented in practice. However, such methods largely rely upon experiential insights and qualitative assessments, leaving a gap in the ability to quantitatively assess the economic and environmental impacts of design choices. To bridge this gap, we investigate existing efforts and present a framework for DfRem that integrates established design and remanufacturing practices into a cohesive workflow with quantitative assessments. To demonstrate its efficacy for making practical design changes for remanufacturing, we apply the framework to a hydraulic manifold in a transmission system for heavy-duty tractors. Through this industry-relevant case study, we focus on showcasing the practical utility of our framework. Based on the identified design modifications from remanufacturability analysis, we estimate the reductions in life cycle costs, energy consumption, and emissions. Afterward, the modifications are tested using physical experiments with plans for integration into future iterations of the hydraulic manifold design and production. We anticipate this framework can illustrate the process of remanufacturing that ensures improvements in sustainability while maintaining performance and reliability standards.
Integrity Evaluation of Boundary Function of Main Components in Nuclear Plants during Severe Accidents
Authors: Tsukimori Kazuyuki , Yada Hiroki 
Published: January 2025

Abstract
After the accident at the Fukushima Daiichi nuclear power plant, very strict safety measures were implemented for nuclear power plants in Japan. It thus becomes a crucial issue if the safety of a plant is maintained or not at beyond design basis events, that is, whether it is possible or not to keep radioactive materials inside the facility during severe accidents. In other words, it is crucial to determine whether the integrity of the boundary of the components that contain radioactive materials can be maintained under beyond design basis loading, such as during mega-earthquake and excessive temperature and/or pressure increase.
In this study, head plates and bellows were examined as components that compose the parts of the boundary of vessels that contain the primary coolant of a prototype fast breeder reactor. The behaviors of buckling, post-buckling deformation, and penetration failure, that is, loss of boundary function of these components with increasing pressure were investigated. The series of this research program started in FY2013 and the research proceeded step by step. The new result in this paper is the application of the proposed criteria to head plates and bellows, and a conservative estimation of penetration failure of these components is obtained.
Restoring cefepime activity against multidrug-resistant KPC-producing
Klebsiella pneumoniae
by combination with boronic acid inhibitors, MB076 and S02030
Authors: Rojas Laura J. , Nielsen Travis B. , Pantapalangkoor Paul , Taracila Magdalena A. , Introvigne Maria L. , Sharma Rajnikant , Yeshwante Shekhar , Mojica Maria F. , Papp-Wallace Krisztina M. , Hujer Andrea M. , Prati Fabio , Caselli Emilia , Spellberg Brad , Rather Philip N. , Rao Gauri G. , Bonomo Robert A. 
Published: January 2025

ABSTRACT

Foremost in the design of new β-lactamase inhibitors (BLIs) are the boronic acid transition state inhibitors (BATSIs). Two highly potent BATSIs being developed are S02030 and MB076 strategically designed to be active against cephalosporinases and carbapenemases, especially KPC. When combined with cefepime, S02030 and MB076 demonstrated potent antimicrobial activity against laboratory and clinical strains of
Enterobacterales
expressing a variety of class A and class C β-lactamases, including
bla
KPC-2
and
bla
KPC-3
. Static time-kill assays revealed the bactericidal activity of cefepime in combination with S02030 and MB076 against a multidrug-resistant KPC-producing
K. pneumoniae
(KPC-
Kpn
-1), in which a ≥ 3-log
10
decrease in the bacterial density was observed by 6 h.
In vivo
efficacy of MB076 in combination with cefepime was evaluated in a lung infection model where male C57BL/6 mice were infected intranasally with KPC-
Kpn
-1. Cefepime alone administered at 2 h post infection resulted in a 1.07 log
10
CFU reduction at 24 h, while cefepime in combination with MB076 resulted in an enhanced reduction of 2.70 log
10
CFU (
P
< 0.0001) compared to the no treatment control group. In a survival analysis where mice were infected via the tail vein with KPC-
Kpn
-1
,
all mice treated with placebo or cefepime alone (100 mg/kg) died, whereas those treated with a 1:4 molar ratio of cefepime-MB076 survived. Our data demonstrate bactericidal activity and
in vivo
efficacy of cefepime-MB076 comparable to ceftazidime-avibactam and support the continued development of this combination as a new treatment option for infections caused by class A carbapenemase producing
Enterobacterales,
particularly KPC-
Kpn
.
Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen
Authors: Raghunandanan Sajith , Priya Raj , Lin Gaofeng , Alanazi Fuad , Zoss Andrew , Warren Elise , Stewart Philip , Yang X. Frank 
Published: January 2025

ABSTRACT

In
Borrelia burgdorferi
, the causative agent of Lyme disease, differential gene expression is primarily governed by the alternative sigma factor RpoS (σ
S
). Understanding the regulation of RpoS is crucial for elucidating how
B. burgdorferi
is maintained throughout its enzootic cycle. Our recent studies have shown that the homolog of Fur/PerR repressor/activator BosR functions as an RNA-binding protein that controls the
rpoS
mRNA stability. However, the mechanisms regulating BosR, particularly in response to host signals and environmental cues, remain largely unclear. In this study, we uncovered a positive feedback loop between RpoS and BosR, wherein RpoS post-transcriptionally regulates BosR levels. Specifically, mutation or deletion of
rpoS
significantly reduced BosR levels, whereas artificial induction of
rpoS
resulted in a dose-dependent increase in BosR levels. Notably, RpoS does not affect
bosR
mRNA levels but instead modulates the turnover rate of the BosR protein. Moreover, we demonstrated that environmental cues do not directly influence
bosR
expression but instead induce
rpoS
transcription and RpoS production, thereby enhancing BosR protein levels. These findings reveal a new layer of complexity in the RpoN-RpoS regulatory pathway, challenging the existing paradigm and suggesting a need to re-evaluate the factors and signals previously implicated in regulating RpoS via BosR. This study provides new insights into the intricate regulatory networks underpinning
B. burgdorferi
’s adaptation and survival in its enzootic cycle.

IMPORTANCE

Lyme disease is the most prevalent arthropod-borne infection in the United States. The etiological agent,
Borreliella
(or
Borrelia
)
burgdorferi
, is maintained in nature through an enzootic cycle involving a tick vector and a mammalian host. RpoS, the master regulator of differential gene expression, plays a crucial role in tick transmission and mammalian infection of
B. burgdorferi
. This study reveals a positive feedback loop between RpoS and a Fur/PerR homolog. Elucidating this regulatory network is essential for identifying potential therapeutic targets to disrupt
B. burgdorferi
’s enzootic cycle. The findings also have broader implications for understanding the regulation of RpoS and Fur/PerR family in other bacteria.
Evaluation of tumor-colonizing
Salmonella
strains using the chick chorioallantoic membrane model
Authors: Mon Khin K. Z. , Kenney Linda J. 
Published: January 2025

ABSTRACT

The chick embryo chorioallantoic membrane (CAM) tumor model is a valuable preclinical model for studying the tumor-colonizing process of
Salmonella enterica
serovar Typhimurium. It offers advantages such as cost-effectiveness, rapid turnaround, reduced engraftment issues, and ease of observation. In this study, we explored and validated the applicability of the partially immune-deficient CAM tumor model. Herein, we demonstrate that
Salmonella
preferentially colonizes tumors and directly causes tumor cell death. Bacterial migration, tumor colonization, and intra-tumor distribution did not require flagellar-mediated motility. The vast majority of
Salmonella
that colonized the CAM tumor were extracellular. Thus, tumor invasion was independent of both
Salmonella
pathogenicity island-1-encoded and
Salmonella
pathogenicity island-2-encoded type III secretion systems. Surprisingly, the extracellular residence of
Salmonella
on CAM tumors did not require biofilm formation. We evaluated our wild-type parental strain compared to the attenuated clinical strain VNP20009 and discovered a reduced tumor colonization capability of VNP20009. The inability to effectively colonize CAM tumors potentially explains the reduced anti-tumor efficacy of VNP20009. Our work establishes the xenograft CAM model as an informative and predictive screening platform for studying tumor-colonizing
Salmonella
.

IMPORTANCE

Cancer has a major impact on society, as it poses a significant health burden to human populations worldwide.
Salmonella
Typhimurium has demonstrated promise in cancer treatment by exerting direct tumoricidal effects and enhancing host-mediated anti-tumor immunity in xenograft mouse studies. A general understanding of its pathogenesis and the relative ease of genetic manipulation support the development of attenuated strains for therapeutic use. Alternative
in ovo
models, such as the chorioallantoic membrane tumor model, present a suitable screening platform to accelerate the development of therapeutic strains. It allows for rapid evaluation of
Salmonella
strains to assess their efficacy and potential as oncolytic agents. The present study establishes that the
in ovo
tumor model can be utilized as a preclinical tool for evaluating oncolytic
Salmonella
, bridging the gap between
in vitro
and
in vivo
screening.
In vitro
dynamics of rumen microbiota and fermentation profiles with Antler growth of Sika deer
Authors: Li Songze , Wang Shaoying , Zhu Yuhang , Mu Ruina , Wang Tao , Zhen Yuguo , Si Huazhe , Du Rui , Li Zhipeng 
Published: January 2025

ABSTRACT

The rumen microbiota plays a vital role in the nutrient metabolism affecting the growth of velvet antler. However, the fermentation patterns and dynamics of the rumen microbiota across growth stages of velvet antler remain largely unexplored. Here, we employed an
in vitro
fermentation approach to assess fermentation parameters and microbial composition in the rumen liquid of sika deer during the early growth (EG), metaphase growth (MG), and fast growth (FG) phases . Our findings indicated that the levels of short-chain fatty acids (SCFAs), ammonia nitrogen, and gas production increased over fermentation time in all three groups. The concentrations of total SCFAs, ammonia nitrogen, and gas production, along with the proportions of butyrate, isobutyrate, and isovalerate, were markedly higher in the MG and FG groups compared with the EG group. Principal coordinate analysis highlighted significant variations in microbial communities among the EG, MG, and FG groups during the fermentation process. The abundances of
Stomatobaculum
and
Blautia
across the three groups increased over fermentation time, whereas
Bacteroides
,
Lawsonibacter
,
Sporobacter
,
Papillibacter
,
Butyricicoccus
, and
Succiniclasticum
exhibited higher abundances in MG or FG groups than in the EG group after 24 hours of fermentation. Co-occurrence network analysis uncovered positive correlations between butyrate levels and butyrate-producing bacteria (
Stomatobaculum
,
Butyrivibrio
) in the MG and FG groups. Additionally, there were positive correlations between proteolytic bacteria (
Clostridium
and
Roseburia
) and branched-chain volatile fatty acids in the FG group. These findings shed light on the fermentation patterns and microbial dynamics within the rumen of sika deer during different growth periods of velvet antler.

IMPORTANCE

Velvet antlers are distinctive and rapidly growing organs that hold significant value in traditional medicine. Through
in vitro
analysis, our study characterized the dynamics of microbiota and metabolites within the rumen liquid fermentation of sika deer throughout the different antler growth phase. We identified distinct microbial communities at various fermentation time points and observed shifts in fermentation patterns that paralleled antler development. These findings suggest a potentially pivotal role for these microbial dynamics in facilitating the growth process of velvet antlers.