bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Was uns Schizophrenie heisst …“ – Das sowjetische Schizophreniebild in den 1970er und 1980er Jahren und dessen Integration in die internationale Klassifikation der Krankheiten
Authors: Schacht Anastassiya 
Published: November 2023

ZusammenfassungDer Artikel diskutiert die Erarbeitung einer wissenschaftlich kohärenten, international als widerspruchsfrei anerkannten Diagnostik milder Verlaufsformen für Schizophrenie im Lauf des 20. Jahrhunderts mit besonderem Augenmerk auf die sogenannteblandeSchizophrenie, die in der UdSSR der 1970er und 1980er Jahre als Mittel zur politisch motivierten Einweisung von Menschenrechtsaktivist*innen herangezogen wurde. Das Argument verfolgt diesluggish schizophrenia, eine Schöpfung des sowjetischen Psychiaters Andrey Snezhnevsky, von ihrer Entstehung im hochproduktiven internationalen Umfeld der Expert*innen-Netzwerke des frühen 20. Jahrhunderts über die inhaltliche Entkopplung und den begrifflichen Wandel in der epistemisch isolierten sowjetischen Psychiatrie. Dieser Wandel wird auch anhand der Fallstudie mit der Internationalen Klassifikation (ICD) der Krankheiten (durch die Weltgesundheitsorganisation erlassen) veranschaulicht. Anschließend wird anhand verschiedensprachiger Ausgaben der neunten ICD-Revision der Versuch seitens sowjetischer Expert*innen rekonstruiert, international akkordierte Termini an die landesinternen politischen Gegebenheiten anzupassen und die sonst umstritteneblandeSchizophrenie für den heimischen Gebrauch zu legitimieren.
Genome-wide association mapping combined with gene-based haplotype analysis identify a novel gene for shoot length in rice (Oryza sativa L.)
Authors: Yang Tifeng , Dong Jingfang , Zhao Junliang , Zhang Longting , Zhou Lian , Yang Wu , Ma Yamei , Wang Jian , Fu Hua , Chen Jiansong , Li Wenhui , Hu Haifei , Jiang Xianya , Liu Ziqiang , Liu Bin , Zhang Shaohong 
Published: November 2023

Abstract
Key message
Genome-wide association mapping revealed a novel QTL for shoot length across multiple environments. Its causal gene, LOC_Os01g68500, was identified firstly through gene-based haplotype analysis, gene expression and knockout transgenic verification.

Abstract
Strong seedling vigor is an important breeding target for rice varieties used in direct seeding. Shoot length (SL) is one of the important traits associated with seedling vigor characterized by rapid growth of seedling, which enhance seedling emergence. Therefore, mining genes for SL and conducting molecular breeding help to develop varieties for direct seeding. However, few QTLs for SL have been fine mapped or cloned so far. In this study, a genome-wide association study of SL was performed in a diverse rice collection consisting of 391 accessions in two years, using phenotypes generated by different cultivation methods according to the production practice, and a total of twenty-four QTLs for SL were identified. Among them, the novel QTL qSL-1f on chromosome 1 could be stably detected across all three cultivation methods in the whole population and indica subpopulation. Through gene-based haplotype analysis of the annotated genes within the putative region of qSL-1f, and validated by gene expression and knockout transgenic experiments, LOC_Os01g68500 (i.e., Os01g0913100 in RAP-DB) was identified as the causal gene for SL, which has a single-base variation (C-to-A transversion) in its CDS region, resulting in the significant difference in SL of rice. LOC_Os01g68500 encodes a DUF538 (Domain of unknown function) containing protein, and the function of DUF538 protein gene on rice seedling growth is firstly reported in this study. These results provide a new clue for exploring the molecular mechanism regulating SL, and promising gene source for the molecular breeding in rice.
Satisfaction after total knee arthroplasty: a prospective matched‐pair analysis of patients with customised individually made and off‐the‐shelf implants
Authors: Vogel Nicole , Kaelin Raphael , Rychen Thomas , Wendelspiess Séverin , Müller‐Gerbl Magdalena , Arnold Markus P. 
Published: November 2023

AbstractPurposeCustomised individually made (CIM) total knee arthroplasty (TKA) was introduced to potentially improve patient satisfaction and other patient‐reported outcome measures (PROMs). The purpose of this study was to compare PROMs, especially patient satisfaction, of patients with CIM and OTS TKA in a matched‐pair analysis with a 2‐year follow‐up.MethodsThis is a prospective cohort study with a propensity score matching of 85 CIM and 85 off‐the‐shelf (OTS) TKA. Follow‐up was at 4 months, 1 year and 2 years. The primary outcome was patient satisfaction. Secondary outcomes were as follows: overall improvement, willingness to undergo the surgery again, Knee injury and Osteoarthritis Outcome Score (KOOS), Forgotten Joint Score (FJS‐12), High‐Activity Arthroplasty Score (HAAS), EQ‐5D‐3L, EQ‐VAS, Knee Society Score (KSS) and surgeon satisfaction.ResultsPatient satisfaction ranged from 86 to 90% and did not differ between CIM and OTS TKA. The EQ‐VAS after 4 months and the HAAS after 1 year and 2 years were higher for CIM TKA. KOOS, FJS‐12 and EQ‐5D‐3L were not different at follow‐up. The changes in KOOS symptoms, pain and daily living were higher for OTS TKA. The KSS was higher for patients with CIM TKA. Surgeon satisfaction was high throughout both groups. Patients who were satisfied after 2 years did not differ preoperatively from those who were not satisfied. Postoperatively, all PROMs were better for satisfied patients. Patient satisfaction was not correlated with patient characteristics, implant or preoperative PROMs, and medium to strongly correlated with postoperative PROMs.ConclusionPatient satisfaction was high with no differences between patients with CIM and OTS TKA. Both implant systems improved function, pain and health‐related quality of life. Patients with CIM TKA showed superior results in demanding activities as measured by the HAAS.Level of evidenceII, prospective cohort study.
Long-Range Order for Critical Book-Ising and Book-Percolation
Authors: Duminil-Copin Hugo , Garban Christophe , Tassion Vincent 
Published: November 2023

AbstractIn this paper, we investigate the behaviour of statistical physics models on a book with pages that are isomorphic to half-planes. We show that even for models undergoing a continuous phase transition on$${\mathbb {Z}}^2$$Z2, the phase transition becomes discontinuous as soon as the number of pages is sufficiently large. In particular, we prove that the Ising model on a three pages book has a discontinuous phase transition (if one allows oneself to consider large coupling constants along the line on which pages are glued). Our work confirms predictions in theoretical physics which relied on renormalization group, conformal field theory and numerics (Cardy in J Phys A Math Gen 24(22):L131, 1991; Iglói et al. in J Phys A Math Gen 24(17):L1031, 1991; Stéphan et al. in Phys Rev B 82(12):125455, 2010) some of which were motivated by the analysis of the Renyi entropy of certain quantum spin systems.
Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma
Authors: Lai Thu Hang , Wenzel Barbara , Dukić-Stefanović Sladjana , Teodoro Rodrigo , Arnaud Lucie , Maisonial-Besset Aurélie , Weber Valérie , Moldovan Rareş-Petru , Meister Sebastian , Pietzsch Jens , Kopka Klaus , Juratli Tareq A. , Deuther-Conrad Winnie , Toussaint Magali 
Published: November 2023

AbstractGlioma are clinically challenging tumors due to their location and invasiveness nature, which often hinder complete surgical resection. The evaluation of the isocitrate dehydrogenase mutation status has become crucial for effective patient stratification. Through a transdisciplinary approach, we have developed an 18F-labeled ligand for non-invasive assessment of the IDH1R132H variant by using positron emission tomography (PET) imaging. In this study, we have successfully prepared diastereomerically pure [18F]AG-120 by copper-mediated radiofluorination of the stannyl precursor 6 on a TRACERlab FX2 N radiosynthesis module. In vitro internalization studies demonstrated significantly higher uptake of [18F]AG-120 in U251 human high-grade glioma cells with stable overexpression of mutant IDH1 (IDH1R132H) compared to their wild-type IDH1 counterpart (0.4 vs. 0.013% applied dose/µg protein at 120 min). In vivo studies conducted in mice, exhibited the excellent metabolic stability of [18F]AG-120, with parent fractions of 85% and 91% in plasma and brain at 30 min p.i., respectively. Dynamic PET studies with [18F]AG-120 in naïve mice and orthotopic glioma rat model reveal limited blood-brain barrier permeation along with a low uptake in the brain tumor. Interestingly, there was no significant difference in uptake between mutant IDH1R132H and wild-type IDH1 tumors (tumor-to-blood ratio[40−60 min]: ~1.7 vs. ~1.3). In conclusion, our preclinical evaluation demonstrated a target-specific internalization of [18F]AG-120 in vitro, a high metabolic stability in vivo in mice, and a slightly higher accumulation of activity in IDH1R132H-glioma compared to IDH1-glioma. Overall, our findings contribute to advancing the field of molecular imaging and encourage the evaluation of [18F]AG-120 to improve diagnosis and management of glioma and other IDH1R132H-related tumors.
Simulation and experimental study of cuboid and spherical magnetic Fe3O4 nanoparticles prepared with NaOH and NH4OH
Authors: Harris R. A. 
Published: November 2023

AbstractA molecular dynamics study is done on cuboid and spherical Fe3O4 magnetic nanoparticles (NPs) to investigate qualitatively the influence of the molecules NH4OH and NaOH on their binding energy. This is done to determine the stability and therefore likely shape (morphology) and size of the synthesized NPs when these molecules are used as stabilizing agents. We show through molecular dynamics (MD) that small, spherical NPs synthesized with NH4OH, and large, cuboid NPs synthesized with NaOH, are the most stable NP systems and therefore the most likely outcome of a synthesis experiment. Furthermore, we synthesize these systems under similar conditions as predicted and find that when NaOH is used large (29 ± 2 nm), cuboid NPs are formed and when NH4OH is used, small (11 nm ± 2 nm), spherical NPs are formed. The role of pH is further investigated using the desorbed (and unadsorbed hydroxyl groups) as indicators of pH. The magnetic NPs are then synthesized via the co-precipitation method and the resulting NPs characterized for crystallinity, morphology, size and magnetic properties.
Data-driven estimation of scalar quantities from planar velocity measurements by deep learning applied to temperature in thermal convection
Authors: Teutsch Philipp , Käufer Theo , Mäder Patrick , Cierpka Christian 
Published: November 2023

AbstractThe measurement of the transport of scalar quantities within flows is oftentimes laborious, difficult or even unfeasible. On the other hand, velocity measurement techniques are very advanced and give high-resolution, high-fidelity experimental data. Hence, we explore the capabilities of a deep learning model to predict the scalar quantity, in our case temperature, from measured velocity data. Our method is purely data-driven and based on the u-net architecture and, therefore, well-suited for planar experimental data. We demonstrate the applicability of the u-net on experimental temperature and velocity data, measured in large aspect ratio Rayleigh–Bénard convection at $$\textrm{Pr} =7.1$$

Pr
=
7.1

and $$\textrm{Ra} =2\times 10^5,4\times 10^5,7\times 10^5$$

Ra
=
2
×

10
5

,
4
×

10
5

,
7
×

10
5

. We conduct a hyper-parameter optimization and ablation study to ensure appropriate training convergence and test different architectural variations for the u-net. We test two application scenarios that are of interest to experimentalists. One, in which the u-net is trained with data of the same experimental run and one in which the u-net is trained on data of different $$\textrm{Ra}$$
Ra
. Our analysis shows that the u-net can predict temperature fields similar to the measurement data and preserves typical spatial structure sizes. Moreover, the analysis of the heat transfer associated with the temperature showed good agreement when the u-net is trained with data of the same experimental run. The relative difference between measured and reconstructed local heat transfer of the system characterized by the Nusselt number $$\textrm{Nu}$$
Nu
is between 0.3 and 14.1% depending on $$\textrm{Ra}$$
Ra
. We conclude that deep learning has the potential to supplement measurements and can partially alleviate the expense of additional measurement of the scalar quantity.
Association of systemic inflammation with shock severity, 30-day mortality, and therapy response in patients with cardiogenic shock
Authors: Dettling Angela , Weimann Jessica , Sundermeyer Jonas , Beer Benedikt N. , Besch Lisa , Becher Peter M. , Brunner Fabian J. , Kluge Stefan , Kirchhof Paulus , Blankenberg Stefan , Westermann Dirk , Schrage Benedikt 
Published: November 2023

Abstract
Background
Mortality in cardiogenic shock (CS) remains high even when mechanical circulatory support (MCS) restores adequate circulation. To detect a potential contribution of systemic inflammation to shock severity, this study determined associations between C-reactive protein (CRP) concentrations and outcomes in patients with CS.

Methods
Unselected, consecutive patients with CS and CRP measurements treated at a single large cardiovascular center between 2009 and 2019 were analyzed. Adjusted regression models were fitted to evaluate the association of CRP with shock severity, 30-day in-hospital mortality and treatment response to MCS.

Results
The analysis included 1116 patients [median age: 70 (IQR 58–79) years, 795 (71.3%) male, lactate 4.6 (IQR 2.2–9.5) mmol/l, CRP 17 (IQR 5–71) mg/l]. The cause of CS was acute myocardial infarction in 530 (48%) patients, 648 (58%) patients presented with cardiac arrest. Plasma CRP concentrations were equally distributed across shock severities (SCAI stage B–E). Higher CRP concentrations were associated with 30-day in-hospital mortality (8% relative risk increase per 50 mg/l increase in CRP, range 3–13%; p < 0.001), even after adjustment for CS severity and other potential confounders. Higher CRP concentrations were only associated with higher mortality in patients not treated with MCS [hazard ratio (HR) for CRP > median 1.50; 95%-CI 1.21–1.86; p < 0.001], but not in those treated with MCS (HR for CRP > median 0.92; 95%-CI 0.67–1.26; p = 0.59; p-interaction = 0.01).

Conclusion
Elevated CRP concentrations are associated with increased 30-day in-hospital mortality in unselected patients with cardiogenic shock. The use of mechanical circulatory support attenuates this association.

Graphical abstract
Early Eocene Arctic volcanism from carbonate-metasomatized mantle
Authors: Day James M. D. , Pearson D. Graham , Kjarsgaard Bruce A. , Barker Abigail K. , Nowell Geoff M. , Joyce Nancy , Lowry David , Sarkar Chiranjeeb , Harrison Christopher 
Published: November 2023

AbstractMelilitite, nephelinite, basanite, and alkali basalt, along with phonolite differentiates, form the Freemans Cove Complex (FCC) in the south-eastern extremity of Bathurst Island (Nunavut, Canada). New 40Ar/39Ar chronology indicates their emplacement between ~ 56 and ~ 54 million years ago within a localized extensional structure. Melilitites and nephelinites, along with phonolite differentiates, likely relate to the beginning and end phases of extension, whereas alkali basalts were emplaced during a main extensional episode at ~ 55 Ma. The melilitites, nephelinites, and alkali basalts show no strong evidence for significant assimilation of crust, in contrast to some phonolites. Partial melting occurred within both the garnet- and spinel-facies mantle and sampled sources with He, O, Nd, Hf, and Os isotope characteristics indicative of peridotite with two distinct components. The first, expressed in higher degree partial melts, represents a relatively depleted component (“A”; 3He/4He ~ 8 RA, εNdi ~  + 3 εHfi ~  + 7, γOsi ~ 0). The second was an enriched component (“B” 3He/4He < 3 RA, εNdi < – 1 εHfi <  + 3, γOsi >  + 70) sampled by the lowest degree partial melts and represents carbonate-metasomatized peridotite. Magmatism in the FCC shows that rifting extended from the Labrador Sea to Bathurst Island and reached a zenith at ~ 55 Ma, during the Eurekan orogeny. The incompatible trace-element abundances and isotopic signatures of FCC rocks indicate melt generation occurred at the base of relatively thin lithosphere at the margin of a thick craton, with no mantle plume influence. FCC melt compositions are distinct from other continental rift magmatic provinces worldwide, and their metasomatized mantle source was plausibly formed synchronously with emplacement of Cretaceous kimberlites. The FCC illustrates that the range of isotopic compositions preserved in continental rift magmas are likely to be dominated by temporal changes in the extent of partial melting, as well as by the timing and degree of metasomatism recorded in the underlying continental lithosphere.
Safety and outcomes of different endovascular treatment techniques for anterior circulation ischaemic stroke in the elderly: data from the Imperial College Thrombectomy Registry
Authors: D’Anna Lucio , Barba Lorenzo , Foschi Matteo , Romoli Michele , Abu-Rumeileh Samir , Dolkar Tsering , Vittay Orsolya , Dixon Luke , Bentley Paul , Brown Zoe , Hall Charles , Halse Omid , Jamil Sohaa , Jenkins Harri , Kalladka Dheeraj , Kwan Joseph , Malik Abid , Patel Maneesh , Rane Neil , Roi Dylan , Singh Abhinav , Venter Marius , Banerjee Soma , Lobotesis Kyriakos 
Published: November 2023

Abstract
Background
Although previous studies investigated the main predictors of outcomes after endovascular thrombectomy (EVT) in patients aged 80 years and older, less is known about the impact of the procedural features on outcomes in elderly patients. The aim of this study was to investigate the influence of EVT technical procedures on the main 3-month outcomes in a population of patients aged 80 years and older.

Methods
This observational, prospective, single-centre study included consecutive patients with acute LVO ischaemic stroke of the anterior circulation. The study outcomes were functional independence at 3 months after EVT (defined as a mRS score of 0–2), successful reperfusion (mTICI ≥ 2b), incidence of haeamorrhagic transformation, and 90-day all cause of mortality.

Results
Our cohort included 497 patients with acute ischaemic stroke due to LVO treated with EVT. Among them, 105 (21.1%) patients were aged ≥ 80 years. In the elderly group, multivariable regression analysis showed that thromboaspiration technique vs stent-retriever was the single independent predictor of favourable post-procedural TICI score (OR = 7.65, 95%CI = 2.22–26.32, p = 0.001).

Conclusions
Our study suggests that EVT for LVO stroke in the elderly could be safe. The use of thromboaspiration was associated with positive reperfusion outcome in this population. Further studies in larger series are warranted to confirm the present results and to evaluate the safety and efficacy of EVT in the elderly and oldest adults.
A novel twin-grasper assisted mucosal inverted closure technique for closing large artificial gastric mucosal defects
Authors: Cai Qinbo , Chen Huanjie , Hou Haobin , Dong Wenqing , Zhang Lele , Shen Minxuan , Yi Shaoxiong , Xie Rongman , Hou Xun , Lan Wentong , He Yulong , Yang Dongjie 
Published: November 2023

Abstract
Background
Large artificial gastric mucosal defects are always left unclosed for natural healing due to technique difficulties in closure. This study aims to evaluate the feasibility and safety of a new Twin-grasper Assisted Mucosal Inverted Closure (TAMIC) technique in closing large artificial gastric mucosal defects.

Methods
Endoscopic submucosal dissection (ESD) was performed in fifteen pigs to create large gastric mucosal defects. The mucosal defects were then either left unclosed or closed with metallic clips using TAMIC technique. Successful closure rate and the wound outcomes were assessed.

Results
Two mucosal defects with size of about 4.0 cm were left unclosed and healed two months after surgery. Thirteen large gastric mucosal defects were created by ESD with a medium size of 5.9 cm and were successfully closed with the TAMIC technique (100%), even in a mucosal defect with a width up to 8.5 cm. The mean closure time was 59.0 min. Wounds in eight stomachs remained completely closed 1 week after surgery (61.5%), while closure in the other five stomachs had partial wound dehiscence (38.5%). Four weeks later, all the closed defects healed well and 61.5% of the wounds still remained completely closed during healing. There was no delayed perforation or bleeding after surgery. In addition, there was less granulation in the submucosal layer of the closed wound sites than those under natural healing.

Conclusions
The present study suggests that TAMIC is feasible and safe in closing large artificial gastric mucosal defects and could improve mucosal recovery compared to natural healing process.
Der optimale Betriebspunkt in der sensorgestützten Sortierung
Authors: Friedrich Karl , Pomberger Roland , Koinig Gerald 
Published: November 2023

ZusammenfassungAbhängig von der Verfügbarkeit der Abfallströme werden sensorgestützte Sortiermaschinen derzeit typischerweise nicht am optimalen Betriebspunkt betrieben, sondern entweder über- oder unterfahren. Abhängig von der Durchsatzrate und der Zusammensetzung des Eingangsstroms können mathematische Ansätze für vorgegebene Idealmischungen gefunden werden. In diesem Forschungsartikel wird untersucht, ob und unter welchen Umständen diese Methoden bei sensorgestützten Sortiermaschinen eingesetzt werden können. Um Aussagen zu ermöglichen, werden neu gewonnene Daten aus realen Abfällen auf drei sensorgestützten Sortieranlagen mit vorhandenen Daten für selbst erstellte Idealmischungen verglichen. In einer Aufbereitungsanlage für Ersatzbrennstoffe werden für die Versuche in regelmäßigen Abständen fünf Proben von 3D-Kunststoffen gezogen. Mithilfe von Regressionsmodellen, die aus mathematischen Ansätzen erstellt werden, wird der optimale Betriebspunkt ermittelt, um ein bestimmtes sensorgestütztes Sortierergebnis hinsichtlich Reinheit und Ausbeute zu erreichen. Der wichtigste Beitrag dieses Forschungsartikels für Anlagenbetreiber besteht darin, dass die Reinheit um 20 % gesteigert werden kann, ohne dass wesentliche Änderungen am Sortiersystem erforderlich sind.
Explainable offline automatic signature verifier to support forensic handwriting examiners
Authors: Diaz Moises , Ferrer Miguel A. , Vessio Gennaro 
Published: November 2023

AbstractSignature verification is a critical task in many applications, including forensic science, legal judgments, and financial markets. However, current signature verification systems are often difficult to explain, which can limit their acceptance in these applications. In this paper, we propose a novel explainable offline automatic signature verifier (ASV) to support forensic handwriting examiners. Our ASV is based on a universal background model (UBM) constructed from offline signature images. It allows us to assign a questioned signature to the UBM and to a reference set of known signatures using simple distance measures. This makes it possible to explain the verifier’s decision in a way that is understandable to non-experts. We evaluated our ASV on publicly available databases and found that it achieves competitive performance with state-of-the-art ASVs, even when challenging 1 versus 1 comparisons are considered. Our results demonstrate that it is possible to develop an explainable ASV that is also competitive in terms of performance. We believe that our ASV has the potential to improve the acceptance of signature verification in critical applications such as forensic science and legal judgments.