bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute inspiratory resistance training enhances endothelium‐dependent dilation and retrograde shear rate in healthy young adults
Authors: Tavoian Dallin , Mazzone Josie L. , Craighead Daniel H. , Bailey E. Fiona 
Published: February 2024

AbstractInspiratory resistance training (IRT) yields significant reductions in resting blood pressure and improves vascular endothelial function. Our objective was to quantify the acute effects of IRT on brachial artery flow‐mediated dilation (FMD) and shear rates (SRs) in healthy men and women. Twenty young adults (22.9 ± 3.4 years; 10 male, 10 female) completed a single bout of IRT or Rest condition in a randomized crossover design. Brachial artery FMD was performed before, 10 min after, and 40 min after the assigned condition. Brachial artery blood flow velocities were collected during IRT, separated by breathing cycle phase, and converted into SRs. FMD improved 10 min post‐IRT (+1.86 ± 0.61%; p = 0.025) but returned to baseline by 40 min post‐IRT (p = 0.002). Anterograde SR decreased by 10% and retrograde SR increased 102% during resisted inspiration, relative to baseline SR (p < 0.001). Anterograde SR increased by 7% in men and women (p < 0.001) and retrograde SR decreased by 12% in women but not men (p = 0.022) during unresisted expiration, relative to baseline SR. A single bout of IRT elicits a transient enhancement in FMD in both men and women. Acute IRT‐related enhancements in SRs may contribute to sustained improvements in FMD that have been reported previously.
In vitro, in vivo metabolism and quantification of the novel synthetic opioid N-piperidinyl etonitazene (etonitazepipne)
Authors: Berardinelli Diletta , Taoussi Omayema , Carlier Jeremy , Tini Anastasio , Zaami Simona , Sundermann Tom , Busardò Francesco Paolo , Auwärter Volker 
Published: February 2024

Abstract

Objectives
N-piperidinyl etonitazene (etonitazepipne) is a newly synthesized opioid related to the 2-benzylbenzimidazole analog class. Etonitazepipne has been formally notified and placed under intensive monitoring in Europe in January 2022. Nitazenes have high affinity at µ-opioid receptor (MOR). Etonitazepipne, specifically shows a EC50 of 2.49 nM, suggesting about 50 times higher potency combined with higher efficacy compared to morphine. Antinociceptive potency l (‘hot plate test’ with rats) was 192-fold greater than that of morphine.

Methods
Here we report on a post-mortem case involving etonitazepipne and its quantification using a standard addition method (SAM) through liquid chromatography tandem mass spectrometry (LC-MS/MS). In addition, characterization and identification of phase I human metabolites using in vitro assay based on pooled human liver microsomes (pHLM) was performed along with the analysis of authentic urine samples by means of high-performance liquid chromatography high-resolution tandem mass spectrometry (LC-HRMS/MS).

Results
The concentration of etonitazepipne in post-mortem blood and urine was 8.3 and 11 ng/mL, respectively. SAM was validated by assessing the following parameters: intraday and interday repeatability, matrix effect and recovery rate in post-mortem blood. A total of 20 and 14 metabolites were identified after pHLM incubation and urine analysis, respectively. Most pronounced in vitro and in vivo transformations were O-deethylation, hydroxylation, ketone reduction, and combinations thereof.

Conclusions
Considering small traces of the parent drug often found in real cases, the identification of metabolic biomarkers is crucial to identify exposure to this drug. O-deethylated, oxidated metabolites, and combination thereof are proposed as urinary biomarkers along with the parent compound.
MetaLo: metabolic analysis of Logical models extracted from molecular interaction maps
Authors: Aghakhani Sahar , Niarakis Anna , Soliman Sylvain 
Published: February 2024

Abstract
Molecular interaction maps (MIMs) are static graphical representations depicting complex biochemical networks that can be formalized using one of the Systems Biology Graphical Notation languages. Regardless of their extensive coverage of various biological processes, they are limited in terms of dynamic insights. However, MIMs can serve as templates for developing dynamic computational models. We present MetaLo, an open-source Python package that enables the coupling of Boolean models inferred from process description MIMs with generic core metabolic networks. MetaLo provides a framework to study the impact of signaling cascades, gene regulation processes, and metabolic flux distribution of central energy production pathways. MetaLo computes the Boolean model’s asynchronous asymptotic behavior, through the identification of trap-spaces, and extracts metabolic constraints to contextualize the generic metabolic network. MetaLo is able to handle large-scale Boolean models and genome-scale metabolic models without requiring kinetic information or manual tuning. The framework behind MetaLo enables in depth analysis of the regulatory model, and may allow tackling a lack of omics data in poorly addressed biological fields to contextualize generic metabolic networks along with improper automatic reconstructions of cell- and/or disease-specific metabolic networks. MetaLo is available at https://pypi.org/project/metalo/ under the terms of the GNU General Public License v3.
Terahertz metamaterials for light-driven magnetism
Authors: Pancaldi Matteo , Vavassori Paolo , Bonetti Stefano 
Published: February 2024

Abstract
We describe the design of two types of metamaterials aimed at enhancing terahertz field pulses that can be used to control the magnetic state in condensed matter systems. The first structure is a so-called “dragonfly” antenna, able to realize a five-fold enhancement of the impinging terahertz magnetic field, while preserving its broadband features. For currently available state-of-the-art table top sources, this leads to peak magnetic fields exceeding 1 T. The second structure is an octopole antenna aimed at enhancing a circularly-polarized terahertz electric field, while preserving its polarization state. We obtain a five-fold enhancement of the electric field, hence expected to exceed the 1 MV/cm peak amplitude. Both our structures can be readily fabricated on top of virtually any material.
Multiscale characterization of the UV aging resistance and mechanism of light stabilizer-modified asphalt
Authors: Zhao Wensheng , Fang Guotao , Qin Xiao , Mao Jie 
Published: February 2024

Abstract
To clarify the effect and mechanism of hindered amine light stabilizer (HALS) on the UV aging behavior of asphalt binder, T622-HALS was selected as the modifier for UV aging resistance of asphalt. The physicochemical properties and microstructure of T622 light stabilizer were comprehensively analyzed. The light stabilizer-modified asphalt was prepared and placed in the UV radiation chamber for UV aging treatment. Scanning electron microscope and atomic force microscope were used to analyze the microscopic morphology evolution of light stabilizer-modified asphalt induced by UV radiation. The thermal properties and functional group composition changes in light stabilizer-modified asphalt during UV aging were studied by using the thermogravimetric and infrared spectroscopy combined testing system. The decay laws of the physical and rheological performances of light stabilizer-modified asphalt were studied during UV aging process, and the effect of light stabilizer on the UV aging behavior of asphalt binder was clarified. The research results indicated that HALSs could alleviate the microcracks and roughness change on the surface of asphalt and reduce the content of functional groups such as carbonyl and sulfoxide in asphalt. Furthermore, HALS could reduce the value difference of physical and rheological properties of asphalt before and after UV aging, significantly improving the UV aging resistance of asphalt binder.
Performance of Febrile Infant Decision Tools on Hypothermic Infants Evaluated for Infection
Authors: Westphal Kathryn , Adib Hania , Doraiswamy Vignesh , Basiago Kevin , Lee Jennifer , Banker Sumeet L. , Morrison John , McCartor Saylor , Berger Stephanie , Schmit Erinn O. , Van Meurs Annalise , Mitchell Meredith , Lee Clifton , Wood Julie K. , Tapp Lauren G. , Kunkel Deborah , Halvorson Elizabeth E. , Potisek Nicholas M. ,   Hypothermic Young Infant Research Collaborative
Published: February 2024

BACKGROUND
Given the lack of evidence-based guidelines for hypothermic infants, providers may be inclined to use febrile infant decision-making tools to guide management decisions. Our objective was to assess the diagnostic performance of febrile infant decision tools for identifying hypothermic infants at low risk of bacterial infection.

METHODS
We conducted a secondary analysis of a retrospective cohort study of hypothermic (≤36.0 C) infants ≤90 days of age presenting to the emergency department or inpatient unit among 9 participating sites between September 1, 2016 and May 5, 2021. Well-appearing infants evaluated for bacterial infections via laboratory testing were included. Infants with complex chronic conditions or premature birth were excluded. Performance characteristics for detecting serious bacterial infection (SBI; urinary tract infection, bacteremia, bacterial meningitis) and invasive bacterial infection (IBI; bacteremia, bacterial meningitis) were calculated for each tool.

RESULTS
Overall, 314 infants met the general inclusion criteria, including 14 cases of SBI (4.5%) and 7 cases of IBI (2.2%). The median age was 5 days, and 68.1% of the infants (214/314) underwent a full sepsis evaluation. The Philadelphia, Boston, IBI Score, and American Academy of Pediatrics Clinical Practice Guideline did not misclassify any SBI or IBI as low risk; however, they had low specificity and positive predictive value. Rochester and Pediatric Emergency Care Applied Research Network tools misclassified infants with bacterial infections.

CONCLUSIONS
Several febrile infant decision tools were highly sensitive, minimizing missed SBIs and IBIs in hypothermic infants. However, the low specificity of these decision tools may lead to unnecessary testing, antimicrobial exposure, and hospitalization.
Cambio climático y variabilidad espacio-temporal (serie 1980-2020) de la temperatura en Tolima, Colombia
Authors: Urrego Pereira Yenny Fernanda , García Lozano Jairo , Vega Jhon Jairo , Rodriguez Valencia Alexa Valentina , Quesada Ortíz Nataly 
Published: February 2024

El cambio climático es uno de los mayores desafíos que enfrenta la humanidad y desde ahora se deben tomar acciones para disminuir sus impactos sobre el medio natural, los sistemas agricolas y la vida futura en el planeta. En la presente investigación se analizó la variación espacio-temporal de la temperatura del aire en el Tolima, Colombia, con el fin de detectar tendencias que evidencien cambio climático y modificaciones en la clasificación climática de Köppen en el departamento. En este trabajo se utilizó una base de datos climatológica integrada por 37 estaciones gestionadas por el Instituto de Hidrología, Meteorología y Estudios Ambientales (IDEAM). La base de datos se dividió en dos series de tiempo: (1980-1999) y (2000-2020) y se analizó la temperatura, considerando épocas secas y lluviosas y las fases Niño-Niña-Neutro del fenómeno ENSO, con el propósito de identificar patrones de diferencia en la temperatura y clasificación climática entre las series de tiempo. Luego, las tasas de aumento de la temperatura del aire identificadas en zonas particulares del Tolima fueron utilizadas para la construcción de modelos de estimación de la temperatura para los próximos 20 años. El análisis mostró que el 55 % de las estaciones presentan tendencia de aumento de la temperatura, y para los próximos 20 años se proyecta un aumento de la temperatura entre 0.08 °C y 3.25 °C. Este aumento sería más acelerado e intenso que lo previsto por el IDEAM, para el peor escenario se daría un forzamiento radiactivo de 8 W m-2 día-1. Por otra parte, la clasificación de Köppen no cambió para las dos series de tiempo 1980-99 y 2000-20, y tampoco para la serie proyectada 2020-40. Sin embargo, el incremento de la temperatura observado y proyectado sugiere aumento de las tasas de evaporación que podrían aumentar la vulnerabilidad a sequías e incendios forestales en el Tolima.
Efecto de la temperatura ambiente en la producción de leche de vacas Holstein en el departamento de Nariño, Colombia
Authors: Trejo Casanova Carmen del Rocío , Sánchez Guerrero Hugo , Timarán Rivera Edmundo Andrés , Burgos Arcos Álvaro Javier , Solarte Portilla Carlos Eugenio , Rivera Palacio Juan Camilo , Molina Benavides Raúl Andrés 
Published: February 2024

La temperatura ambiental es un factor influyente en el bienestar animal y su impacto se refleja principalmente en la salud y productividad. El objetivo de esta investigación fue evaluar el efecto de la temperatura ambiental mínima sobre producción y calidad de leche en vacas Holstein, realizando control lechero en fincas del departamento de Nariño (Pasto, Pupiales y Guachucal). Se registró el volumen de leche producido por vaca en el día del control y se obtuvieron muestras de leche para su posterior análisis (grasa, proteína, sólidos totales y células somáticas). La información de temperatura ambienta se obtuvo de las estaciones meteorológicas del Instituto de Hidrología, Meteorología y Estudios Ambientales (Ideam) cercanos a los hatos. Se empleó un modelo lineal mixto que contempla el efecto fijo de la temperatura ambiental mínima, número de parto, días de lactancia y, como efecto aleatorio, el distrito lechero. Los resultados muestran que la composición de la leche y el conteo de células somáticas no fueron afectados por las temperaturas ambientales mínimas, pero sí hay un efecto significativo sobre la producción de vacas con seis o más partos, pues se dio una disminución de hasta 2.6 l. Esta reducción en la producción de leche posiblemente se atribuye a la disminución del consumo y a la utilización de la energía para la producción de calor y mantenimiento de la temperatura corporal como mecanismo de supervivencia. Para posteriores investigaciones se sugiere incluir variables fisiológicas del animal (temperatura corporal, consumo de materia seca, niveles de cortisol) y del ambiente (precipitación, viento, humedad relativa, radiación solar).
Nuevos “habitus” de consumo entre los jóvenes asalariados rurales
Authors: Martínez Valle Luciano , Martínez Godoy Diego 
Published: February 2024

En este artículo se analiza el proceso de integración a nuevos patrones de consumo de los jóvenes asalariados rurales en un territorio de la sierra ecuatoriana, donde predominan los agronegocios de flores y brócoli. Se busca mostrar las condiciones estructurales que permiten a los jóvenes asalariados adoptar nuevos habitus más cercanos al consumo de mercancías globales, proceso estrechamente relacionado con su posición ocupada en el campo social. En una primera parte, analizamos la relación entre consumo y “habitus” en el medio rural desde distintas perspectivas teóricas sociológicas. En una segunda parte, a partir de un estudio de caso, se abordan las tendencias del consumo entre los jóvenes rurales. En una tercera parte se reflexiona sobre la importancia de nuevas pautas de consumo entre los jóvenes asalariados a través del acceso a dos tipos de mercancías globales (motocicleta y celular) que se han convertido en nuevos objetos simbólicos y de prestigio.
RADEN SAWUNGGALING TOMB'S HISTORICAL NARRATIVES AND ITS PROSPECTIVE IMPACT ON SURABAYA'S TOURISM
Authors: Rafsanjani Afida Rizma Liana , Nafisah Ainatun 
Published: February 2024

ABSTRACTThis research is field research, namely by carrying out field activities that are used to obtain various data from the information needed. The aim of this research is to determine the history, existence, layout and potential of the Raden Sawunggaling Tomb as a religious tourism object. The results of this study are the existence of Raden Sawunggaling's grave on Jalan Lidah Wetan gang III, Lidah Wetan Village, Lakarsantri District, Surabaya City. The tomb was found around 1908, some say it was 1901. The local community responded well to the existence of Raden Sawunggaling's tomb, even though there had been suspicions about Raden Sawunggaling. Raden Sawunggaling's grave was officially made a Cultural Heritage site in 2013. The Raden Sawunggaling grave area is in the middle of a residential area with a building area of around 44 m2. The potential for the tomb to become a religious tourism object is very good, because Lidah Wetan sub-district is a big economic wheel for West Surabaya, such as the Pakuwon shopping center and also UNESA. However, Raden Sawunggaling's tomb also has several challenges to become an even bigger tourist attraction.Keywords: Joko Berek, Raden Sawunggaling, Surabaya, Tourism. ABSTRAKPenelitian ini merupakan penelitian lapangan, yakni dengan melakukan kegiatan lapangan yang digunakan untuk mendapat berbagai data dari informasi yang dibutuhkan. Tujuan penelitian ini ialah untuk mengetahui sejarah, eksistensi, tata letak, dan potensi Makam Raden Sawunggaling sebagai Objek Wisata Religi. Hasil dari penelitian ini adalah keberadaan makam Raden Sawunggaling ada di jalan Lidah Wetan gang III, Kelurahan Lidah Wetan, Kecamatan Lakarsantri, Kota Surabaya. Makam tersebut ditemukan sekitar tahun 1908-an, ada juga yang menyebut tahun 1901. Masyarakat sekitar merespon baik atas keberadaan makam Raden Sawunggaling, walaupun sempat terjadi kecurigaan terhadap Raden Sawunggaling. Makam Raden Sawunggaling resmi dijadikan sebagai situs Cagar Budaya pada tahun 2013. Kawasan makam Raden Sawunggaling berada di tengah-tengah pemukiman penduduk dengan luas bangunan sekitar 44 m2. Potensi makam bila dijadikan objek wisata religi sangat bagus, karena di kecamatan Lidah Wetan sebagai roda ekonomi Surabaya Barat yang besar seperti adanya pusat perbelanjaan Pakuwon dan juga UNESA. Namun, makam Raden Sawunggaling juga memiliki beberapa tantangan untuk dijadikan daya tarik wisata yang lebih besar lagi.Kata kunci: Joko Berek, Raden Sawunggaling, Surabaya, Wisata.
IMPLANT SURVIVAL IN RENAL-TRANSPLANTED PATIENTS: A PROSPECTIVE LONG-TERM STUDY.
Authors: Berton Federico , Zotti Matteo , Rapani Antonio , Costantinides Fulvia , Castronovo Gaetano , Di Lenarda Roberto , Stacchi Claudio 
Published: February 2024

Abstract
The present study aims to assess the feasibility of implant rehabilitation in kidney-transplanted patients. Patients with kidney transplantation included in periodontal supportive care and at least one year of dialysis with mono- or partial edentulism were eligible for this study. Histomorphometric evaluation of the harvested bone was matched with radiological bone assessment. Implant stability was also monitored with RFA and ITV. Fixed cemented prostheses have been delivered after conventional loading protocol. Supportive periodontal therapy has been administered. Eleven patients (9 males and 2 females) were included. The mean age was 58.1 ± 9.9 years. A total of 17 implants were inserted and analyzed. Mean ITV was 39.3 ± 23.8 Ncm. The mean primary stability (ISQ) at T0 was 71.7 ± 10.5, whereas the mean secondary stability at T1 was 73.0 ± 7.3. The minimum follow-up was 62 months, with a maximum of 84 months (7 years) reached by four patients. Fourteen out of 15 implants were in function at a 5-year follow-up (survival rate 93.3%). Two implants showed peri-implantitis. Seventeen bone samples were collected (13 in the mandible and 4 in the maxilla). The mean percentage of marrow spaces and lamellar bone was 41.6% and 58.4%, respectively. Class 3, according to Misch classification, was found as the mean value of radiological bone density. It can be concluded that implant-supported rehabilitation in kidney-transplanted patients is possible. Adequate periodontal maintenance allows implant rehabilitation in kidney transplanted patients with long-term sufficient survival rates.
Tathwîr Al-Mawâd Al-Ta’lîmiyah li Mahârah al-Istimâ’ al-Mustamidah min as-Saqâfah al-Mahalliyah ladâ Tholibât al-Jâmi’ah
Authors: Rosyad Rosyad , Baihaqi M. , Nuha Muhammad Afthon Ulin 
Published: February 2024

Purpose- This study aims to develop teaching materials for listening skills based on local content, determine the level of validity of teaching materials, and measure the level of effectiveness of the developed teaching materials.
Design/Methodology/Approach- This study uses research and development methods based on the Borg and Gall model with special treatment from researchers. Sources of data from students, expert councils, and policy makers in Islamic boarding schools were obtained through observation, interviews, and tests. The data will then be analyzed qualitatively and quantitatively simultaneously with interactive analysis and t-test. The subjects of this study were all female students of the intensive Arabic language program who were determined through a purposive technique, with a total of 25 samples.
Findings- Among the results of this study were the results of the pre-test reaching 1882 with a rate of 75.28, while in the post-test it reached 2045 with a rate of 82.16. The effectiveness of the developed material is seen at a score of 12.69 which is greater than the table score at the 2.80 level. Thus teaching materials developed based on local content are effective in improving the listening skills of female students of the intensive Arabic language program.
Research Limitation/Implications- The formal finding of this research is that teaching materials that are arranged thematically based on local content can improve Arabic listening skills for students.