bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the pathogenesis, clinical, laboratory diagnosis and treatment of the recent monkeypox virus outbreak
Authors: Goia Aneta-Rada , Muntean Delia , Musta Virgil , Herlo Alexandra , Vulpie Silvana , Izmendi Oana , Jumanca Romanita , Licker Monica 
Published: January 2024

Abstract
Human mpox is a zoonotic disease, caused by the mpox virus (MPXV), that can spread either between animals and humans or humans and humans. In 1970 the first human case of mpox was reported in Zaire, Democratic Republic of the Congo (DRC). Other notable human mpox outbreaks in non-endemic countries were identified in June 2003 in the United States, in July 2021 in Dallas (USA), and the most recent one in May 2022 in Europe in the United Kingdom (UK). During the 2022 outbreak, sexual intercourse was observed to be the most prevalent transmission method, although other means should not be ignored, such as the involvement of respiratory droplets, exposure to surfaces and skin suspected of contamination. In the context of the current mpox outbreak, we consider it important and necessary to correctly identify the virus, use the proper laboratory testing for a correct diagnosis of mpox, understand the means of prophylaxis, and apply the correct treatment, highlighting these facts being the aim of this study.
Anti-thyroid peroxidase (TPO) antibodies – Comparative analysis of two automatic methods, ECLIA and CMIA
Authors: Manescu Ion Bogdan , Luca Andreea , Hutanu Adina , Truta Andreea , Dobreanu Minodora 
Published: January 2024

Abstract

Introduction: Anti-thyroid peroxidase autoantibodies (TPO) is an essential diagnostic tool for autoimmune disorders of the thyroid gland. However, TPO results are not always comparable due to differences between methods. Here, we aimed to investigate the differences between two modern laboratory methods for TPO measurement: electrochemiluminescence (ECLIA) and chemiluminescence microparticle (CMIA) immunoassays.

Methods: A total of 234 serum samples were tested on two methods: Cobas-e601 (ECLIA) and Alinity i (CMIA). TPO results were compared statistically both quantitatively and qualitatively (results were coded as positive/negative, according to ECLIA/CMIA reference ranges.

Results: The precisions of both methods were acceptable compared with the claims of the manufacturer. There was a very strong, but unsatisfactory correlation between the two methods (Pearson r=0.85). Passing-Bablok regression revealed a significant deviation from linearity (Cusum p<0.01) and an unacceptable quantitative relationship: intercept −7.61, slope 1.10. Moreover, a visual analysis of overall and medical decision level-focused Bland-Altman plots confirmed the lack of quantitative agreement. As for the qualitative analysis, the concordance rate between methods was 218/234 (93.1%). The agreement was considered good to very good according to the inter-rater agreement test: weighted Cohen κ = 0.805.

Conclusions: The qualitative agreement between Cobas-e601 (ECLIA) and Alinity i (CMIA) was good, therefore the two methods may be used indiscriminately for initial testing of patients suspected of thyroid gland autoimmune diseases. However, due to poor quantitative agreement, the two methods should not be used interchangeably for monitoring as the results may mislead both physicians and patients, possibly leading to medical errors.
Decarbonisation of Road Transport as a Key Element for Achieving Climate Neutrality
Authors: Mielczarek-Mikołajów Justyna 
Published: January 2024

Abstract
This article considers the issue of climate neutrality, which is becoming increasingly important in view of current European Union (EU) policies. It is necessary to mention the requirement that EU countries achieve climate neutrality by 2050, with the intermediate target being the reduction of harmful exhaust gases to 55 per cent compared to 1990. The achievement of climate neutrality particularly affects transport, which is one of the most crucial sectors of the economy in this regard. Therefore, the author will point out the process of decarbonisation of road transport in the context of both public and private transport, highlighting the most important barriers to the development of this process, using Poland as an example.
Perbaikan Jaringan Tegangan Rendah Dengan Sisip Trafo Distribusi Fase Tunggal Untuk Mengurangi Overload dan Jatuh Tegangan PT PLN (Persero) ULP Yogyakarta Kota
Authors: Ramadhan Muhammad Dwi Cahyo , Ginting Nina Loenca Br , Muflih Haidar Nabil , Ningrum Nur Risya Difa Kusuma , Nugraha Candra Febri 
Published: January 2024

Transformator distribusi berperan penting dalam jaringan distribusi untuk mentransformasikan energi listrik dari sumber ke pelanggan. Keadaan tersebut akan berkaitan dengan permasalahan pada proses distribusi energi listrik. Pada standar PLN, kapasitas trafo ditetapkan menjadi overload apabila beban melebihi 80% dari kapasitas trafo yang terpasang. Overload dapat menyebabkan peningkatan suhu transformator yang berpotensi merusak isolasi dan berpotensi terjadinya pemutusan penyaluran listrik ke konsumen. Transformator yang telah terpasang B&D 50kVA yang telah terpasang pada tiang 17A/U3-30 wilayah Jalan Belibis, Wonocatur, Banguntapan, Yogyakarta. Transformator tersebut mengalami pembebanan hingga 112,5%. Dalam penelitian ini, sisip trafo menjadi solusi untuk menekan presentase overload dan jatuh tegangan. Sisip trafo sebenarnya sudah dilakukan pada lapangan, maka dalam penelitian ini akan dilakukan analisis pengaruh setelah sisip dengan penentuan lokasi optimal melalui simulasi. Dari hasil simulasi ETAP 12.6.0 nilai sisip trafo pada tiang 1/S3-19 lapangan dapat memperbaiki nilai tegangan pada ujung pelanggan sebesar 0,94 p.u. dengan pembebanan pada transformator sisip sebesar 86,6% dan trafo existing sebesar 35,60%. Akan tetapi, terdapat penentuan lokasi optimal yaitu tiang 18/S3-17 berdasarkan nilai tegangan paling baik pada ujung pelanggan yaitu 0,94 p.u. dengan transformator existing dalam kondisi normal sebesar 58,1% pembebanan dan pada transformator sisip sebesar 65,3%. Transformator sisip dapat menurunkan overload dan jatuh tegangan pada pelanggan, dan dengan menentukan lokasi optimal dapat menambahkan efisiensi analisis mengenai dampak perkembangan beban dan nilai tegangan.
Kata Kunci— transformator; overload; jatuh tegangan; ETAP; optimal
EKSPRESI DINAMIS MIR-320C PADA KANKER OVARIUM
Authors: Guspratiwi Reny , Kartika Aprilia Indra 
Published: January 2024

Kanker ovarium mengalami peningkatan insidensi dan kematian yang disebabkan oleh kesulitan dalam mendeteksi kanker pada stadium awal dan belum ada uji skrining yang efektif untuk kanker ovarium. Dibutuhkan metode deteksi yang memiliki sensitivitas dan spesifisitas yang tinggi berupa biomarker yang bersirkulasi di dalam plasma darah berupa mikroRNA. Deteksi melalui mikroRNA diharapkan dapat meminimalkan rasa sakit atau minimal invasif. Penelitian analisis profil mikroRNA yang berperan dalam kanker ovarium perlu dilakukan untuk mendapatkan biomarker deteksi awal minimal invasif kanker ovarium yang tepat. Analisis profil ekspresi mikroRNA pada kanker ovarium dilakukan dengan isolasi plasma darah, sintesis cDNA, dan qRT-PCR sampel yang disatukan, dan qPCR miR-320c. Profiling mikroRNA pada kanker ovarium dilakukan dengan metode pooling sampel, kemudian dilanjutkan dengan kuantifikasi mikroRNA yang mengalami peningkatan dan penurunan paling signifikan secara individu sampel. Hasil analisis profil ekspresi mikroRNA pada kanker ovarium menunjukkan peningkatan ekspresi miR-320c baik pada serous maupun pada mucinous. Hasil kuantifikasi ekspresi individu menunjukkan penurunan ekspresi miR-320c pada stadium awal dan peningkatan yang signifikan miR-320c pada stadium lanjut kanker ovarium. Penelitian ini menunjukkan bahwa ekspresi mikroRNA dapat berbeda-beda pada masing-masing orang.
Kata kunci : kanker ovarium, miR-32Oc, profil ekspresi, minimal invasif
The EFFECTIVENESS OF EDUCATION USING VIRTUAL REALITY VIDEO MEDIA ON THE STATUS OF ORAL HYGIENE IN PUBLIC ELEMENTARY SCHOOL STUDENTS 10 SUNGAI SAPIH PADANG CITY
Authors: Rahmawati Laili , Lestari Citra , Endo Mahata Intan Batura , Ningrum Valendriyani 
Published: January 2024

According to the Data and Information Centre of the Ministry of Health of the Republic of Indonesia (2018), the prevalence of caries in Indonesia is 88.8%. The World Health Organisation (WHO) reports that 60-90% of school children worldwide experience caries, with the disease being most prevalent in children aged 6-12 years. Dental caries is a disease that can infect and damage tooth structure. One of the risk factors for caries is plaque accumulation, which is associated with poor oral hygiene. The Personal Hygiene Performance Modified (PHP-M) is a method used to measure plaque on mixed teeth. This research is a quasi-experiment with a one-group pretest-posttest design. The sampling technique used was purposive sampling, with a total of 27 samples meeting the inclusion and exclusion criteria. The study found a significant improvement in oral hygiene status after participants received an educational intervention using virtual reality video media. Specifically, there was a decrease in plaque scores after brushing teeth following the intervention compared to before. The statistical analysis using the Wilcoxon test showed a significant difference with a p-value of less than 0.05. The study found that the number of students with excellent oral hygiene status increased from 15 (40.5%) before the intervention to 36 (97.3%) after the intervention. These results suggest that the use of virtual reality video media is an effective method for improving oral hygiene.
Keywords: Personal Hygiene Performance Modified (PHP-M)., Virtual Reality (VR)., Oral Hygiene.
HUBUNGAN ANTARA HIPERURISEMIA DENGAN HIPERTENSI DI RSUD SANJIWANI GIANYAR TAHUN 2019
Authors: Sarilan I Putu , Putra IGB Gita Pranata , Cahyawati Putu Nita 
Published: January 2024

Latar Belakang: Hipertensi masih menjadi penyebab utama penyakit kardiovaskular dan kematian di dunia, termasuk di Indonesia. Berdasarkan pada penelitian sebelumnya ditemukan adanya kontroversi terkait hubungan antara hiperurisemia dan hipertensi. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara hiperurisemia dengan kejadian hipertensi tersebut. Metode: Penelitian ini dilakukan di RSUD Sanjiwani Gianyar dengan desain penelitian observasional analitik cross-sectional. Data diambil dari rekam medis pasien pada periode Januari–Desember 2019. Teknik pengambilan sampel menggunakan purpossive sampling dengan jumlah sampel sebanyak 104. Hasil: Karakteristik sampel pada penelitian ini yaitu mayoritas berusia lebih dari 60 tahun (51%) dan didominasi oleh jenis kelamin laki-laki (57.7%). Kejadian hiperurisemi pada pasien hipertensi adalah 68.3%. Kejadian hiperurisemia lebih banyak terjadi pada pasien hipertensi grade 1 (68.8%) dibandingkan dengan hipertensi grade 2 (67.2%). Hasil analisis menggunakan uji korelasi Spearman. menemukan bahwa nilai p>0.05, r -0.010. Kesimpulan: Hasil yang menunjukan bahwa tidak terdapat hubungan signifikan antara hiperurisemia dan hipertensi di RSUD Sanjiwani Gianyar tahun 2019.
Kata kunci : Hipertensi, Hiperurisemia, RSUD Sanjiwani Gianyar
Legal Implications in The Implementation of Rehabilitation Assessment for Narcotics Abuse Addicts
Authors: Pasaribu Wilson Bugner F. , Kalo Syafruddin , Ablisar Madiasa , Suwarto  
Published: January 2024

Objective: The implementation of rehabilitation assessments for drug addicts has always been criticized for injustice in the service system. This can be seen from various legal policies that are considered discriminatory against the lower middle-class society. Drug addicts who are rehabilitated by wealthy groups will easily get luxury facilities from rehabilitation institutions. It's different from the poor who are always complicated by administrative problems during the rehabilitation process. Therefore, this research is considered important to find out the existing policy problems and what solutions should be applied to drug addicts.

Theoretical framework: To deal with the problem of drug users, practical rehabilitation assessment is very important. Based on Law Number 35 of 2009 concerning Narcotics, drug abusers are like people who have two legs: one in the legal dimension and the other in the health dimension. At the legal level, abuse is a legal violation that must be punished because it violates applicable regulations. On the other hand, drug abusers are considered chronic addicts who need to be cured through rehabilitation.

Method: Data collection is sourced from normative data related to the rehabilitation assessment of narcotics abuse in Indonesia.

Results and conclusion: The results of the study show that the legal implications in the implementation of rehabilitation assessments for addicts and victims of narcotics abuse can shape changes in patients for the better, although in practice there are still those who repeat their actions (recidivist).

Implications of the research: In addition, the Government is still constrained in terms of costs to build rehabilitation institutions in a comprehensive and equitable manner.

Originality/value: Thus causing differences, discrimination, and injustice between addicts and narcotics victims who become patients.
Possible Legislative Policies for Combating Drug, Applied to Mandatory Drug Testing for Government Employees
Authors: Badran Doaa Mohamed Ibrahim 
Published: January 2024

Objective: Saudi Arabia is actively working to improve citizens' quality of life and achieve comprehensive development, with a specific focus on combating drug abuse. Strict measures, including legislative policies, have been implemented to prevent, treat, and rehabilitate individuals involved in drug abuse. The emphasis is on creating a drug-free work environment for government employees, enhancing workplace safety, and improving overall performance through regular and random drug tests. Clear guidelines and protocols ensure transparency and fairness in policy implementation.

Methods: The study adopts a descriptive-analytical methodology, shedding light on the description and analysis of the actual reality of drug control and its impact on the development process within the country. The study relies on a range of primary and secondary sources, as well as scientific publications.

Results: The suggestion of conducting drug tests for employees may stir controversy due to privacy concerns and potential impact on employee integrity. To ensure the fair achievement of this goal, policies should include clear procedures for handling results and provide opportunities for rehabilitation and reemployment. Implementing drug testing policies requires enhancing transparency, clearly stating objectives and procedures to employees, confirming their rights, and specifying measures taken in case of positive results. Harmony between policies and legislation is necessary, emphasizing employee rights and striking a balance between security and individual dignity.

Suggestions: The social impact on an employee undergoing drug testing and showing positive results should be considered. Individuals using drugs often face discrimination and exclusion, and to avoid this, coherent legislative policies should be developed to balance the interests of the work environment with the rights and privacy of employees. This will help avoid injustice and negative effects on individuals who need support and assistance in changing their behavior.
Surgical Shunting Versus Trans-Jugular Intrahepatic Portosystemic Shunt for Recurrent Variceal Bleeding in Portal Hypertension Due to Liver Cirrhosis: An Evidence-Based Case Report
Authors: Magfira Nadya , Nurrafiani Arie Rozzaqi , Jasirwan Chyntia Olivia Maurine , Suhartono Raden 
Published: January 2024

Aim: This evidence-based case report aims to determine whether the surgical shunt is better than the trans-jugular intrahepatic portosystemic shunt (TIPS) to prevent re-bleeding in patients with portal hypertension due to liver cirrhosis. Method: Literature searching was performed in 4 online databases, Cochrane, PubMed, Embase, and SCOPUS. Three meta-analyses were appraised critically.Results: Of all meta-analyses included, the internal validities were poor and only included a small number of trials. However, the results show that surgical shunt is better for preventing variceal re-bleeding with varied heterogeneities.Conclusion: Surgical shunts may have benefits over TIPS in preventing variceal re-bleeding.
Analisis Jaringan Akses Fiber to The Home Menggunakan Teknologi Gigabit Passive Optical Network
Authors: Nurus Meida , Nurdiawa Odi , Martanto Martanto 
Published: January 2024

Serat optic merupakan saluran transmisi atau jenis kabel yang terbuat dari kaca atau plastic yang sangat halus dan lebih kecil dari sehelai rambut, dan dapat digunakan untuk mentransmisikan sinyal cahaya dari suatu tempat ke tempat lain, sumber cahaya yang digunakan biasanya adalah laser atau LED. Teknologi fiber merupakan media yang tidak diragukan untuk menyediakan bandwidth yang besar, tidak dipengaruhi interferensi gelombang elektromagnetik, bebas korosi dan menyediakan rugi-rugi minimal untuk transportasi data. Sekarang ini kebanyakan dari backbone jaringan yang ada telah dikonstruksikan dengan fiber optik. Di dalam jaringan fiber optik masalah yang terjadi adalah perambatan cahaya yang kurang maksimal disebabkan oleh makrobending yang terjadi di sepanjang alur kabel atau jaringan. Kajian secara eksperimental untuk menganalisa redaman pada makrobending telah dilakukan. Pengambilan data dilakukan dengan mengukur perubahan nilai intensitas cahaya akibat adayanya gejala pembengkokan (bending) melalui perangkat Optical Power Meter. Penelitian dilakukan pada CV. Anugerah Tekhnik Pratama adalah penelitian asosiatif dengan menggunakan metode analisis kuantitatif. T-hitung sebesar 129.262, dan t-table sebesar 2.0057. Maka dapat ditarik kesimpulan bahwa T-hitung > dari T-table yakni sebesar 129.262> 2.0057. Hal tersebut berarti H0 diterima dan Ha ditolak H0 : analisis jaringan akses fiber to the home (ftth) menggunakan teknologi gigabit passive optical network lebih besar dari 60 %.
Difficulties of Translating News Political Terms from English into Arabic and vice versa in Selected Newspapers
Authors: Ibrahim Hasan Salam , Shaban Ahmad Abdulkareem 
Published: January 2024

This research deals with the role of translation in the political field in conveying the precise and objective meaning of political terms, and talks about the strategies, rules and techniques adopted by the translator to translate these terms. It highlights the difficulties translators face in translating political terms, which prevent them to produce the true meaning of those terms. The research was conducted through samples of the study represented by Arabic and English texts taken from news agencies and newspapers.
The research also shows the difference between the literal meaning and the implied meaning of the political term, through the theoretical use of an analytical descriptive approach. It includes about 10 selected political terms from political articles published in both Arabic and English in Al-Forat newspaper and the Al-Anbaa Iraqi News Agency, five terms for each.
The most important results are that samples are sometimes flexible and not biased towards a party or a particular point of view, and also the difficulty of translating political terms related to the audience and the original context. All of the above is explained by the samples under study, which we will see in the research.
How Reproducible Are Manual Therapy Interventions in Trials for Low Back Pain? A Scoping Review
Authors: Ruzich Jon J. , Klopper Mareli , Dohrmann Chris M. , Rhon Daniel I. , Young Jodi L. 
Published: January 2024

OBJECTIVES: To assess the reproducibility of manual therapy interventions used in clinical trials for low back pain (LBP), and summarize knowledge gaps in assessing the reproducibility of manual therapy interventions for LBP.DESIGN: Scoping review.LITERATURE SEARCH: PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), and Embase were searched for trials from inception through April 2023.STUDY SELECTION CRITERIA: Randomized controlled trials were included if they described the use of manual therapy to treat LBP in adults 18 to 65 years old and were accessible in English.DATA SYNTHESIS: The Consensus on Exercise Reporting Template (CERT) checklist, used for exercise reporting, was previously modified for manual therapy reporting. This 11-item modified CERT was used to extract details of manual therapy reporting in the included trials. Frequency counts were calculated to identify items most and least commonly reported.RESULTS: Of 128 trials, none reported all 11 items of the modified CERT. The most commonly reported items were the description of how the application of manual therapy was decided (n = 113, 88.3%) and a description of adjunct interventions provided (n = 82, 64.1%). The least reported items were the description of an associated home program (n = 27, 21.1%) and a detailed description of the application of manual therapy (n = 22, 17.2%).CONCLUSION: Reporting of manual therapy interventions in trials investigating LBP was poor overall, limiting the reproducibility of these treatments. Using a checklist designed explicitly for manual therapy intervention reporting may improve reproducibility of these interventions and help align clinical outcomes with experimental findings. J Orthop Sports Phys Ther 2024;54(4):248-257. Epub 29 January 2024. doi:10.2519/jospt.2024.12201
RESIDUAL CONTENTS OF SELECTED HEAVY METALS IN COMMERCIAL CANNED FISH IN EGYPT: DIETARY INTAKES AND HEALTH RISK ASSESSMENT
Authors: Morshdy Alaa Eldin , Hussein Mohamed , Darwish Wageh , Yousef Rawayeh , Tharwat Ahmed 
Published: January 2024

Abstract: Canned fish is considered as an important fish product that can supply humans with part of their needs from essential amino acids, polyunsaturated fatty acids, vitamins, and minerals. However, canned fish might become a source of human exposure to xenobiotics such as heavy metals. This study aimed to estimate the residual contents of six heavy metals, namely lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), aluminum (Al), and tin (Sn) in four kinds of commercially purchased canned fish products from Zagazig city, Egypt. Eighty imported samples including canned anchovies, canned mackerel, canned sardine, and canned tuna (20 samples/each canned fish product) were examined. Besides, we calculated the estimated daily intakes (EDI), and potential health risks, hazard quotient (HQ), and hazard index (HI), of the examined heavy metals associated with the consumption of such fish products among Egyptian population. The obtained results revealed residual concentrations of the tested heavy metals higher than the established maximum permissible limits (MPL) by European Commission for Pb in 20%, 95%, and 100% of the examined canned anchovies, sardine, and tuna, respectively. Whereas, 80%, 100%, 100%, and 100% of the examined canned anchovies, mackerel, sardine, and tuna, respectively exceeded MPL of As. None of the examined samples exceeded MPL of Cd, Hg, Al, and Sn. The calculated HQ and HI for the examined heavy metals based on the daily intakes revealed values greater than 1.0 indicating potential human health risks. Therefore, it is highly advisable to reduce our daily intake of canned fish. Keywords: Heavy metals; canned fish, estimated daily intakes; health risk assessment; Egypt