bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytic analysis of a C‐shaped microshield broadside‐coupled coplanar waveguide with buried ground strip
Authors: Gong Xinbao , Yao Ji , Zhou Xilang 
Published: January 2003

AbstractA conformal mapping method and partial capacitance techniques are used to derive simple and accurate closed‐form expressions of odd‐ and even‐mode capacitances and characteristic impedances for a C‐shaped microshield broadside‐coupled coplanar waveguide (CMBCCPW) with buried ground strip. Numerical results are compared to those provided by other authors. Good agreement is obtained. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 36: 214–216, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10723
Concept of a compact dual‐band dual‐port microstrip base station antenna for mobile communication systems
Authors: Gadzina A. , Słobodzian P. 
Published: January 2003

AbstractThis paper presents a concept of a dual‐band dual‐port microstrip base station antenna for mobile telecommunication systems. The main part of the paper describes considerations on the antenna array configuration as well as antenna pattern synthesis. As an application example, a model of a dual‐band dual‐port microstrip antenna for GSM900 and GSM1800 systems, along with measured data, are described. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 36: 218–221, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10725
Study of non‐linear variation of dielectric constant with moisture for mug grains using microstrip ring structure
Authors: Abegaonkar Mahesh P. , Karekar R. N. , Cho Young‐Ki , Aiyer R. C. 
Published: January 2003

AbstractThe non‐linear variation of dielectric constant with moisture in the grains using a microstrip ring resonator (MRR) is reported. A MRR is perturbed using mug grains (Phaseolus Radiatus Linn.) having different moisture contents (7% to 42%), at 8 azimuthal orientations (partial overlay). Out of the two orthogonal degenerate modes (even and odd) of the MRR, only the even mode is sensitive to the strength of perturbation (grain moisture). The perturbation equation for even mode resonance frequency fe reported by Yogi et al. [5] is modified for the present case. It is seen that the variation of dielectric constant with moisture content in the grains is non‐linear. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 36: 221–224, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10726
Electromagnetic scattering from a thick circular aperture
Authors: Lee Haeng S. , Eom Hyo J. 
Published: January 2003

AbstractElectromagnetic scattering from a circular aperture in a thick conducting plane is analyzed. Numerical computations are performed to evaluate the near and far zone radiation fields in terms of the aperture geometry and incident polarization state. A salient difference in the near‐zone field behavior between TM and TE wave incidences is discussed. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 36: 228–231, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10728
Efficient implicit finite element analysis of sheet forming processes
Authors: van den Boogaard A. H. , Meinders T. , Huétink J. 
Published: January 2003

AbstractThe computation time for implicit finite element analyses tends to increase disproportionally with increasing problem size. This is due to the repeated solution of linear sets of equations, if direct solvers are used. By using iterative linear equation solvers the total analysis time can be reduced for large systems. For plate or shell element models, however, the condition of the matrix is so ill that iterative solvers do not reach the huge time‐savings that are realized with solid elements. By introducing inertial effects into the implicit finite element code the condition number can be improved and iterative solvers perform much better. An additional advantage is that the inertial effects stabilize the Newton–Raphson iterations. This also applies to quasi‐static processes, for which the inertial effects finally do not affect the results.The presented method can readily be implemented in existing implicit finite element codes. Industrial size deep drawing simulations are executed to investigate the performance of the recommended strategy. It is concluded that the computation time is decreased by a factor of 5 to 10. Copyright © 2003 John Wiley & Sons, Ltd.
Practical methods for a posteriori error estimation in engineering applications
Authors: Prudhomme Serge , Oden J. Tinsley , Westermann Tim , Bass Jon , Botkin Mark E. 
Published: January 2003

AbstractThis work presents an extension of the goal‐oriented error estimation technique to the engineering analysis of three‐dimensional linear elastic bodies. In the series of examples shown, the errors are estimated with respect to local displacement and stress components. The paper also introduces novel means to compute lower bounds on the error in the energy norm based on a cost‐effective postprocessing of the upper bound error estimates. The numerical results indicate that the method can be used effectively for complex engineering applications. Copyright © 2003 John Wiley & Sons, Ltd.
Application of symmetric indirect Trefftz method to free vibration problems in 2D
Authors: Chang Jiang‐ren , Liu Ru‐feng , Kuo Shyh‐rong , Yeih Weichung 
Published: January 2003

AbstractA symmetric indirect Trefftz method is developed to solve the free vibration problem of a 2D membrane. It is proved that in this approach the spurious eigensolution exists, and an auxiliary matrix is constructed to help extraction of the spurious solution using the generalized singular‐value decomposition. In addition to the spurious eigensolution, this regular formulation suffers from its ill‐posed nature, i.e. the numerical instability. In order to deal with the numerical instability, the Tikhonov's regularization method, in conjunction with the generalized singular‐value decomposition, is suggested. The proposed approach has some merits when compared with other regular boundary element formulations reported so far; namely the capacity of representing eigenmodes and the ability to deal with a multiply connected domain of genus 1. Several numerical examples are demonstrated to show the validity of the current approach. Copyright © 2003 John Wiley & Sons, Ltd.
Enhancement of medication recall using medication pictures and lists in telephone interviews
Authors: Kimmel Stephen E. , Lewis James D. , Jaskowiak Jane , Kishel Lori , Hennessy Sean 
Published: January 2003

AbstractPurposeTo determine the effect of reading medication lists and providing medication pictures on recall of non‐aspirin non‐steroidal anti‐inflammatory drugs (NANSAIDs) during telephone interviews in a case–control study.MethodsAfter a series of indication‐specific questions, a list of all available NANSAIDs was read to study participants and a series of pictures was reviewed when available. Recall was defined as enhanced if a participant recalled NANSAID use only after the memory aids.ResultsAmong the 1484 participants who reported NANSAID use, 94 (6.3%) recalled their NANSAID use only after the memory aids. Several groups demonstrated enhanced recall following the memory aids: men (odds ratio (OR): 1.73; 95% confidence interval (CI): 1.11, 2.69), users of non‐prescription versus prescription NANSAIDs (OR 2.28; 95% CI: 1.21, 4.30), those using >2 other medications (OR 1.69; 95% CI: 1.06, 2.69), those who did not have all of their medication containers available during the interview (OR 1.58; 95% CI: 1.03, 2.42) and cases versus controls (OR 1.90; 95% CI: 1.11, 3.28).ConclusionThe reading of medication names with the availability of medication photographs enhanced recall by approximately 6%. The use of this type of memory aid may reduce recall bias in case–control studies that rely on medication recall, depending on the overall prevalence of medication use and the effect size of the drug on the outcome. Copyright © 2003 John Wiley & Sons, Ltd.
Agreement between patient self‐report and a Veterans Affairs national pharmacy database for identifying recent exposures to antibiotics
Authors: Metlay Joshua P. , Hardy Christine , Strom Brian L. 
Published: January 2003

AbstractPurposeThe dramatic rise in antibiotic drug resistance among community pathogens has stimulated interest in the epidemiological relationship between antibiotic exposure and drug resistance. In assessing the strength of this relationship, studies are hampered by the lack of data on the accuracy of subject self‐report of antibiotic exposure. The authors compared self‐report with pharmacy dispensing data to determine the accuracy of self‐reported antibiotic exposure.MethodsThe study design was a cross‐sectional survey of veterans seen at the Philadelphia Veterans Affairs (VA) Medical Center in 1999 and 2000. Subjects reported exposures to antibiotics, antihypertensive drugs and nonsteroidal anti‐inflammatory drugs through a structured telephone interview. The instrument included open‐ended questions, condition‐specific prompts and drug‐specific prompts. Subject responses were linked to a national VA pharmacy database that served as the reference standard for evaluating self‐reported exposures.ResultsThe authors found that the sensitivity of self‐report of antibiotic exposure increased with increasing use of prompts. A comprehensive assessment of antibiotic exposure identified 73% of antibiotic exposures, compared to 73% of antihypertensive drug exposures and 92% of nonsteroidal anti‐inflammatory drug exposures.ConclusionsAssessment of antibiotic exposure appears to be comparable to assessment of other chronic and episodic drugs. Multistep assessment of exposure improves the sensitivity of assessment. Copyright © 2002 John Wiley & Sons, Ltd.
Antipsychotic medication coprescribing in a large state hospital system
Authors: Jaffe Ari B. , Levine Jerome 
Published: January 2003

AbstractPurposeTo systematically characterize antipsychotic medication coprescribing (‘polypharmacy’) in a large state hospital system.MethodsAll antipsychotic prescriptions written for all adult in‐patients (N=8212) in New York state‐run civil facilities for the year 1999 were identified using the Integrated Research Database (IRDB) created by the Information Systems Division of the Nathan Kline Institute for Psychiatric Research. Antipsychotics were considered to be intentionally coprescribed only when both were prescribed for an overlapping period of 28 days.ResultsCoprescribing of typical, atypical, and depot antipsychotics comprised 31% of antipsychotic prescribing episodes. Medications were usually coprescribed with medications from outside their own antipsychotic class. Patient factors, such as age, diagnosis, and history of prior hospitalization, affected coprescribing rates ( p<0.001 for all indicated variables). Atypical antipsychotic medications were less likely to be given with another antipsychotic than were oral or depot typical medications.ConclusionsCoprescribing of antipsychotic drugs is a common practice in the New York State hospital system. The analysis of large clinical databases can yield valuable information about the kinds of complex pharmacotherapy regimens actually utilized in the treatment of the most severely ill patients. Copyright © 2002 John Wiley & Sons, Ltd.
Patient information leaflets–helpful guidance or a source of confusion?
Authors: Bjerrum Lars , Foged Annette 
Published: January 2003

AbstractBackgroundAccording to the European Community Directive 92/27, pharmaceutical companies are responsible for working out patient information leaflets (PILs) for all products marketed, and every PIL should comply with the Summary of Product Characteristics (SPC) and be phrased so that it is easily understandable by the patient. However, the volume of information included in the PIL may differ for different brands, and furthermore, the same drug may be registered for different indications. Patients may therefore receive different drug information when they renew prescriptions for the same generic drug.ObjectivesTo examine if PILs on different brands of generically identical drugs contain inconsistent and diverging information that may lead to confusion.DesignCase‐finding among patients who contacted a pharmacy because of problems related to the information retrieved from the PIL.SettingInquiries to a Danish pharmacy during one year (1 June 2000–31 May 2001).ResultsDifferent brands of generically identical products included PILs with substantial inconsistencies. Diverging information about indications for drug use, adverse effects, drug‐drug interactions and precautions and considerations concerning pregnancy and breastfeeding resulted in inquiries to the pharmacy.ConclusionPatients may be confused by inconsistent information in PILs from different brands of generically identical drugs. Confusion about drug treatment may lead to reduced compliance and initiatives should be taken to coordinate information in PILs covering the same generic product. Copyright © 2003 John Wiley & Sons, Ltd.
Lesions missed on prostate biopsies in cases sent in for consultation
Authors: Kronz Joseph D. , Milord Rolando , Wilentz Robb , Weir Edward G. , Schreiner Stephanie R. , Epstein Jonathan I. 
Published: January 2003

AbstractBackgroundThere are no reports on how often lesions are missed on prostate needle biopsies.MethodsOver a 10‐month period, 8/99 to 5/00, 3,251 prostate biopsy cases were seen in consultation.ResultsWe identified 87 (2.7%) patients with missed lesions (n = 9 academic hospitals; n = 44 community hospitals; n = 34 commercial labs). Overall, 119 lesions were missed in 87 patients. Missed lesions were as follows: small atypical glands suspicious for cancer (41 lesions in 35 patients), prostatic adenocarcinoma (39 cancers in 32 patients), high grade prostatic intraepithelial neoplasia (HGPIN) (34 lesions in 30 patients), and HGPIN with adjacent small atypical glands (five lesions in five patients)—some men with more than one type of missed lesion. Detection of the missed lesions would have resulted in either: a definite change in care in 15 of 3,251 (0.5%) patients or a possible change in care (bilateral cancer vs. unilateral cancer; HGPIN vs. atypical) in 17 (0.5%) patients. In 21 (24%) of the cases, the slides were seen by at least two pathologists prior to consultation at our hospital.ConclusionsAlthough the number of prostate biopsies with missed lesions in a consult‐based population of prostate biopsies appears relatively high (2.7%), the detection of the missed lesions would have only effected a definite change in care in 0.5% of all patients or a possible change in care in another 0.5% of patients. Our data underestimates missed lesions, as the entire specimen was not submitted for review in 41% of cases. Although our incidence of missed lesions gives some indication as to the magnitude of the problem, it cannot be equated with the risk of missing lesions in unselected cases. Prostate 54: 310–314, 2003. © 2003 Wiley‐Liss, Inc.
Characteristics of human prostasomes isolated from three different sources
Authors: Carlsson Lena , Nilsson Ove , Larsson Anders , Stridsberg Mats , Sahlén Göran , Ronquist Gunnar 
Published: January 2003

AbstractBackgroundProstasomes are organelles secreted by human prostate epithelial cells and appear freely in semen. Most prostasomal functional and biochemical characteristics have been settled on basis of seminal prostasomes (SP).MethodsThree types of prostasomes, viz., from seminal plasma, prostate gland (native), and prostate cancer bone metastasis, were isolated and compared for their biochemical and functional characteristics.ResultsFlow cytometry showed that all three types of prostasomes had a similar size distribution and electrophoresis revealed close similarities in banding pattern. Also, a high cholesterol/phospholipid ratio and some marker enzymes were distinctive common features. The unusual chromogranin B (CgB)/chromogranin A (CgA) ratio with CgB in abundance over CgA, previously found only in SP, was also valid for the native (NP) and metastasis‐derived prostasomes (MP). The latter prostasome type contained a 10‐fold higher amount of CgA compared to the others. SP and MP showed the same promotive effect on sperm forward motility, whereas NP did not. All three prostasome types exhibited an antibacterial activity against Bacillus megaterium.ConclusionsSince the three prostasome types were isolated from different environments, our data support the view that the common characteristics were prostasome‐genuine. Prostate 54: 322–330, 2003. © 2003 Wiley‐Liss, Inc.
Increased expression of bone morphogenetic protein‐7 in bone metastatic prostate cancer
Authors: Masuda Hiroshi , Fukabori Yoshitatsu , Nakano Katsuya , Takezawa Yutaka , cSuzuki Takanori , Yamanaka Hidetoshi 
Published: January 2003

AbstractBackgroundProstate cancer frequently metastasizes to bone. The skeletal metastases of prostate cancer origin are osteoblastic rather than osteolytic. Recently, the expression of bone morphogenetic proteins (BMPs) in prostate cancer cell lines was detected. The present study indicated the existence of BMP‐7 in normal prostate tissue, but its function has not been clarified. The mechanism by which prostate cancer causes osteoblastic metastasis is not clear. We investigated the expression of BMP‐7 and ‐6 in normal and metastatic bone tissues to clarify the biological relationship between the expression of BMPs and bone metastasis in prostatic cancer.MethodsSix samples of normal bone tissue and nine samples of bone metastasis tissue were collected during the autopsies of six patients with prostate cancer. Total RNA was extracted from these samples. After reverse transcription (RT) of the RNA samples, the expression of BMP‐6 and ‐7 in each sample was measured by the real‐time quantitative polymerase chain reaction (PCR). Glyceraldehyde phosphate dehydrogenase (GAPDH) was used as an internal standard.ResultsAlthough the expression of BMP‐7 was detected in five out of seven (71%) metastatic bone lesions of prostate cancer, it was not detected in normal bone tissues. The expression level of BMP‐7 was significantly higher in metastatic bone lesions than in normal bone (P < 0.05). There was no significant difference between the level of expression of BMP‐6 in metastatic bone lesions from prostate cancer and the level in normal bone tissue (P = 0.81).ConclusionsThese results suggest that high expression of BMP‐7 in metastatic bone lesions of prostate cancer is related to osteoblastic metastasis. BMP‐7 in the bone metastasis tissue indicates that the cells expressing BMP‐7 probably originated from the prostate, because we have detected high expression of BMP‐7 in the prostate. Prostate 54: 268–274, 2003. © 2003 Wiley‐Liss, Inc.
R726L androgen receptor mutation is uncommon in prostate cancer families in the united states
Authors: Gruber Stephen B. , Chen Hong , Tomsho Lynn P. , Lee Nana , Perrone Erin E. , Cooney Kathleen A. 
Published: January 2003

AbstractBackgroundA mutation in the androgen receptor (AR) gene, namely AR R726L, was described in 2% of Finnish men with sporadic or familial prostate cancer and was associated with an approximately sixfold increased risk of prostate cancer. We set out to determine the incidence of this mutation in a sample of men with either early‐onset and/or familial prostate cancer in the United States.MethodsFive hundred forty‐eight men with prostate cancer from 411 unrelated families participating in the University of Michigan Prostate Cancer Genetics Project (PCGP) were studied. Allele‐specific oligonucleotide hybridization was used to detect the presence of the AR R726L mutation in germline DNA.ResultsNone of the 548 prostate cancer patients studied, including 513 White, 29 African American, 3 Asian, and 3 Hispanic men, were found to carry the AR R726L allele. Therefore, the prevalence of this allele is significantly less than that observed among Finnish men with prostate cancer (Fisher's exact test, P = 0.002).ConclusionsThe AR R726L allele does not account for a significant proportion of early‐onset and/or familial prostate cancer in the United States. Prostate 54: 306–309, 2003. © 2003 Wiley‐Liss, Inc.
Expression of cystatins, high molecular weight cytokeratin, and proliferation markers in prostatic adenocarcinoma and hyperplasia
Authors: Mirtti Tuomas , Alanen Kalle , Kallajoki Markku , Rinne Ari , Söderström Karl‐Ove 
Published: January 2003

AbstractBACKGROUNDProstatic adenocarcinoma is the most common malignancy among men in the western world but the diagnostic and prognostic criteria for it are still not clearly defined. Additional means for its diagnosis and prognosis are clearly needed. Previously it has been shown that cystatin A is expressed in the basal cells of normal prostate and the expression disappears in prostatic carcinoma.METHODSWe have now studied the expression of both cystatins A and B in benign prostatic hyperplasias (BPH), prostatic intraepithelial neoplasias (PIN) and carcinomas of the prostatic epithelium and compared it with the expression of high molecular weight (HMW) cytokeratin as well as the proliferation markers cyclin A and Ki‐67. The expression of the proteins was immunohistochemically assessed using 33 total prostatectomy specimens.RESULTSCystatin A was expressed in the basal cells in all cases of BPH, low‐grade PIN, and high‐grade PIN whereas carcinomas showed no staining of cystatin A. The 34βE12 cytokeratin expression was similar to basal cystatin A staining and was not seen in carcinoma foci. Cystatin B showed both nuclear and cytoplasmic expression in the columnar epithelial cells. The decrease in median cytoplasmic staining of cystatin B in carcinomas compared to other lesions was significant, but there was a significant increase in expression with dedifferentiation of carcinoma. Also cyclin A and Ki‐67 staining were significantly different in non‐carcinomatous foci compared to carcinoma foci and had a remarkably similar negative correlations with basal cystatin A and 34βE12 staining.CONCLUSIONSThe results show that cystatin expression can be used as an aid in the diagnosis of prostatic adenocarcinoma and especially cystatin A in the distinction between high grade PIN and grade I carcinoma. Prostate 54: 290–298, 2003. © 2003 Wiley‐Liss, Inc.
Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid: guanidine, N‐[3‐[(aminoiminomethyl)amino]propyl]‐N‐dodecyl‐, a potential source of error in the analysis of antibacterial agents
Authors: Abraham‐Nordling Mirna , Gudmundsson Gudmundur H. , Grunewald Johan , Agerberth Birgitta , Griffiths William J. 
Published: January 2003

AbstractThe widespread use of antibiotics in modern society has encouraged the search for new antibacterial compounds. In this laboratory investigations are being made to identify and characterise novel antibacterial peptides. With this in mind, the antibacterial properties of human bronchoalveolar lavage (BAL) fluid from sarcoidosis patients is being investigated. In this communication we report on the identification and characterisation of a highly active non‐peptide antibacterial compound isolated from BAL fluid. The structure of this active compound was elucidated by high‐resolution accurate mass and tandem mass spectrometry to be guanidine, N‐[3‐[(aminoiminomethyl)amino]propyl]‐N‐dodecyl‐. This compound does not appear to be endogenous, and its presence in BAL fluid extracts presents a potential source of error in analysis of antibacterial agents. The biological effects of guanidine, N‐[3‐[(aminoiminomethyl)amino]propyl]‐N‐dodecyl‐ have not previously been described in the literature. Copyright © 2002 John Wiley & Sons, Ltd.