bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geriatric nutritional risk index as a predictor of prognosis in hematologic malignancies: a systematic review and meta-analysis
Authors: Yu Qiong , Tian Mengxing , Pi Guoliang , Jia Yegui , Jin Xin 
Published: October 2023

ObjectiveRecent studies have reported inconsistent results regarding the association between geriatric nutritional risk index (GNRI) and clinical outcomes in patients with hematologic malignancies (HMs). We performed a meta-analysis to evaluate the effect of low GNRI on the overall survival (OS) and progression-free survival (PFS) in patients with HMs.Research Methods and ProceduresWe conducted the research via PubMed, Embase, and Cochrane Library databases to identify trials. Exploring the association between GNRI and prognosis in patients with HMs. A meta-analysis of OS and PFS was performed. Quality In Prognostic Studies instrument and Newcastle–Ottawa quality assessment Scale were used to assess the quality of included trials.ResultsFourteen studies enrolling 3,524 patients with HMs were included. Low GNRI was associated with shorter OS (Hazard ratio (HR) = 1.77; 95% CI = 1.44–2.18, p &lt; 0.01) and PFS (HR = 1.63; 95% CI = 1.17–2.27, p &lt; 0.01) in patients with HMs. In the subgroup analysis, GNRI was not significantly associated with prognosis in Chinese patients with HMs (OS, HR =1.33; 95% CI = 0.89–1.98, p = 0.16; PFS, HR = 1.70; 95% CI = 0.72–4.01, p = 0.23). For the subgroup with a GNRI cutoff value less than 98, there was no significant difference in PFS (HR = 1.34; 95% CI = 0.98–1.83, p = 0.06).ConclusionLow GNRI negatively impacted on the prognosis in patients with HMs. Prospective studies to identify the best cut-off value for GNRI are required.
A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model
Authors: Ankul Singh S. , Chandran Lakshmi , Anuragh Singh , Kaliappan Ilango , Rushendran Rapuru , Vellapandian Chitra 
Published: October 2023

This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer’s disease-like condition to enhance translational research. Our review seeks to understand how MSG affects the brain and causes degenerative disorders. Due to significant preclinical data linking glutamate toxicity to Alzheimer’s disease and the lack of a comprehensive review or meta-analysis, we initiated a study on MSG’s potential link. We searched PubMed, ScienceDirect, ProQuest, DOAJ, and Scopus for animal research and English language papers without time constraints. This study used the PRISMA-P framework and PICO technique to collect population, intervention or exposure, comparison, and result data. It was registered in PROSPERO as CRD42022371502. MSG affected mice’s exploratory behaviors and short-term working memory. The brain, hippocampus, and cerebellar tissue demonstrated neuronal injury-related histological and histomorphometric changes. A total of 70% of MSG-treated mice had poor nesting behavior. The treated mice also had more hyperphosphorylated tau protein in their cortical and hippocampus neurons. Glutamate and glutamine levels in the brain increased with MSG, and dose-dependent mixed horizontal locomotor, grooming, and anxiety responses reduced. MSG treatment significantly decreased phospho-CREB protein levels, supporting the idea that neurons were harmed, despite the increased CREB mRNA expression. High MSG doses drastically lower brain tissue and serum serotonin levels. In conclusion, MSG showed AD-like pathology, neuronal atrophy, and short-term memory impairment. Further research with a longer time span and deeper behavioral characterization is needed.Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier [CRD42022371502].
Effects of strain on boundary management: findings from a daily diary study and an experimental vignette study
Authors: Mueller Nicolas , Loeffelsend Sophia , Vater Elke , Kempen Regina 
Published: October 2023

IntroductionTransformations in the work–nonwork interface highlight the importance of effectively managing the boundaries between life domains. However, do the ways individuals manage the boundaries between work and nonwork life change from one day to the next? If so, which antecedents may explain these intra-individual fluctuations in boundary management? Drawing on boundary management, spillover, and resource theories, we investigate daily changes in segmentation preferences and integration enactments as a function of experiencing strain in work and nonwork life. Assuming that changes in segmentation preferences reflect an individual’s strategy to regulate negative cross-role spillover, we suppose that strain increases individuals’ segmentation preferences; at the same time, however, it could force individuals to enact more integration.MethodsWe test our assumptions with data from two studies with different methodological approaches. The first study uses a daily diary research design (Study 1, 425 participants with 3,238 daily observations) in which full-time professionals rated strain in work and nonwork life, segmentation preferences, and integration enactments every evening for 10 workdays. The second study uses an experimental vignette research design (Study 2, 181 participants), where we experimentally manipulated strain in work and nonwork life and investigated causal effects on participants’ hypothetical segmentation preferences.ResultsThe results of multilevel modeling analyses in Study 1 show that segmentation preferences and integration enactments fluctuate from day to day as a function of strain. More specifically, strain is related to preferring more segmentation but enacting more integration. Study 2 replicates the results of Study 1, showing that strain causally affects segmentation preferences.DiscussionThis two-study paper is one of the first to address daily fluctuations in segmentation preferences and integration enactments, extending our knowledge of temporal dynamics in boundary management. Furthermore, it demonstrates that strain is an antecedent of these daily fluctuations, offering starting points for practical interventions.
Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms
Authors: Stewart Zachary , Korsapathy Sanvi , Frohlich Flavio 
Published: October 2023

IntroductionPreliminary studies suggest that infection with Bartonella bacteria can not only cause a characteristic rash, headache, fever, and fatigue but also neuropsychiatric symptoms. To date, this association has only been reported in case studies, and it remains unclear if this association generalizes to larger samples.MethodsWe used Amazon's Mechanical Turk (MTurk) to crowdsource a large sample (N = 996) of individuals to ascertain the extent to which the presence of participant-identified Bartonella-associated cutaneous lesions (BACL) was associated with self-reported measures of anxiety, depression, and schizotypy. Participants were asked to select images of cutaneous lesions they had seen on their own bodies and complete a battery of self-report questionnaires to assess psychiatric symptoms. Participants were not informed that the focus of the study was on potential dermatological lesions associated with Bartonella. Point-biserial correlations were used to determine the potential relationship between selecting a BACL image and the severity of self-reported psychiatric symptoms.ResultsScores of anxiety, depression, and schizotypy were positively and significantly correlated with selecting a BACL image. Furthermore, self-report scores of 10 or higher on the GAD-7 and PHQ-9, which represent the suggested clinical cutoffs for meeting criteria for a depressive or anxiety-related disorder, were also significantly associated with selecting a BACL image. Non-Bartonella-associated cutaneous legions were also significantly associated with self-reported measures of psychiatric symptoms.DiscussionThe current study broadens the link between the presence of BACL and the presence of psychiatric symptoms of anxiety, depression, and schizotypy and extends a potential relationship beyond the small sample sizes of previous case studies and case series. Further investigation is recommended to address limitations and expand on these findings.
Insertion of Transposable Elements in AVR-Pib of Magnaporthe oryzae Leading to LOSS of the Avirulent Function
Authors: Li Jinbin , Lu Lin , Li Chengyun , Wang Qun , Shi Zhufeng 
Published: October 2023

Rice blast is a very serious disease caused by Magnaporthe oryzae, which threatens rice production and food supply throughout the world. The avirulence (AVR) genes of rice blast are perceived by the corresponding rice blast resistance (R) genes and prompt specific resistance. A mutation in AVR is a major force for new virulence. Exploring mutations in AVR among M. oryzae isolates from rice production fields could aid assessment of the efficacy and durability of R genes. We studied the probable molecular-evolutionary patterns of AVR-Pib alleles by assaying their DNA-sequence diversification and examining their avirulence to the corresponding Pib resistance gene under natural conditions in the extremely genetically diverse of rice resources of Yunnan, China. PCRs detected results from M. oryzae genomic DNA and revealed that 162 out of 366 isolates collected from Yunnan Province contained AVR-Pib alleles. Among them, 36.1–73.3% isolates from six different rice production areas of Yunnan contained AVR-Pib alleles. Furthermore, 36 (28.6%) out of 126 isolates had a transposable element (TE) insertion in AVR-Pib, which resulted in altered virulence. The TE insertion was identified in isolates from rice rather than from Musa nana Lour. Twelve AVR-Pib haplotypes encoding three novel AVR-Pib variants were identified among the remaining 90 isolates. AVR-Pib alleles evolved to virulent forms from avirulent forms by base substitution and TE insertion of Pot2 and Pot3 in the 5′ untranslated region of AVR-Pib. These findings support the hypothesis that functional AVR-Pib possesses varied sequence structures and can escape surveillance by hosts via multiple variation manners.
Five New Species of Aureoboletus and Chalciporus (Boletaceae, Boletales) and Their Ethnomycological Aspects
Authors: Ayala-Vásquez Olivia , Martínez-Reyes Magdalena , Pérez-Moreno Jesús , Martínez-González César Ramiro , Pinzón Juan Pablo , de la Fuente Javier Isaac , Castro-Rivera Rigoberto , García-Jiménez Jesús , Balbuena-Carrasco Soledad , Ramírez-Carbajal Eliseete , Yu Fuqiang 
Published: October 2023

Among Boletales, the family Boletaceae has the highest diversity worldwide. Additionally, this fungal group has great ecological relevance because it not only includes mainly ectomycorrhizal but also saprotrophic species. Furthermore, some species are used as food and have sociocultural and economic importance worldwide. In Mexico, the Boletaceae family boasts a substantial number of species, yet our understanding of these species remains far from comprehensive. In this work, by using macro- and micromorphological and phylogenetic analyses of DNA sequences from multi-gene analyses based on ITS, nrLSU, rpb1, rpb2, and tef1, we report five new species belonging to the genera Aureoboletus and Chalciporus: A. ayuukii and A. elvirae from a Quercus scytophylla forest, A. readii from a mixed forest, C. perezsilvae from cloud forest, and C. piedracanteadensis from both a mixed coniferous forest and a Quercus-Pinus forest. In Mexico, four species of Aureoboletus are used as a food source, and in this work, we add another one, A. readii, which is traditionally consumed by members of the Tlahuica-Pjiekakjoo culture, who are located in the central part of the country. This work contributes to our knowledge of two genera of Boletaceae in a geographical area that is scarcely studied, and thus, our understanding of its biocultural relevance is enriched.
THEORETICAL CONCEPTS OF METHODOLOGICAL INNOVATIONS IN THE INSTITUTION OF HIGHER EDUCATION
Authors: KOLESNYK O. , LAVRYNENKO S. , TARANENKO K. 
Published: October 2023

Theoretical concepts of methodological innovations in higher education institutions were comprehensively analyzed in the article. It must be stated that among the whole spectrum of pedagogical technologies, we prefer interactive ones. The implementation of these methods allows to conduct diagnostics and assessment of knowledge acquired by students as well as to conduct control of theoretical concepts of the necessary material, the result of all these must be filling of information gaps between existing and unknown knowledge for students. It must be stated that these technologies are effective both for conducting lectures and practical classes. Dialogic communication between the lecturer and the audience leads to mutual understanding, interaction, joint solution of general but significant tasks for each of the participants. At the same time, during the lecturer's dialogue with future teachers, they learn to think critically, solve complex problems, taking into account the analysis of the circumstances and the information provided. No less important is the formation of alternative approaches, making deliberate decisions, skills of debating with the lecturer or fellow students, taking as a basis their own vision of the problem. Particular attention is paid to contextual learning, which greatly contributes to the optimization of learning. It is primarily based on students' creative and productive thinking, actions and communication, but not exclusively on the processes of perception or memory. Contextual learning is organized in such a way that knowledge, skills and abilities are not transferred as objects of student activity, but as means of solving tasks of professional activity.We found out that interactive technologies and strategy of contextual learning contribute to the consciousness of professional position and self-actualization of the future teacher. These technologies help to level out some "problem areas" of professional training of future teachers, guarantee the achievement of the expected results of the educational process and improvement of the quality of graduates’ training.
Pengaruh Budaya Organisasi dan Inovasi Kerja Terhadap Kinerja Pegawai Kantor Dinas Pertanian, Merauke Papua
Authors: Tuakra Yulianus 
Published: October 2023

Berbagai keluhan dan masalah yang timbul atas kinerja pelayanan yang dilakukan oleh pegawai di kantor Dinas Pertanian Kabupaten Merauke. Kinerja pegawai di Dinas Kabupaten Merauke belum dapat merespon kebutuhan masyarakat secara optimal terutama dalam hal membantu masyarakat akan pelayanan sesuai dengan tugas pokok dan fungsinya. Metode penelitian yang digunakan adalah metode survei dengan pendekatan analisis regresi dan korelasional. Sampel yang terdiri dari 95 responden yang telah ditentukan. Hasil penelitian menunjukkan korelasi antara Budaya Organisasi dengan Kinerja Pegawai diperoleh R Square yaitu sebesar 49,1% dan sisanya sebesar 50,9% kontribusi oleh variabel yang lain, korelasi antara Inovasi Kerja terhadap Kinerja Pegawai diperoleh R Square yaitu sebesar 48,5% dan sisanya sebesar 51,5% kontribusi oleh variabel yang lain, korelasi antara Budaya Organisasi dan Inovasi Kerja secara bersama-sama terhadap Kinerja Pegawai diperoleh R Square yaitu sebesar 53,6% dan sisanya sebesar 46,4% kontribusi oleh variabel yang lain. Disarankan bahwa : 1) Keberadaan nilai budaya pada suatu organisasi merupakan sesuatu hal yang penting karena budaya organisasi yang baik akan turut membentuk iklim kerja yang baik. 2) Inovasi Kerja di Kantor Dinas Pertanian Kabupaten Merauke sudah cukup baik, hal ini harus dipertahankan dan jikalau perlu lebih ditingkatkan lagi; 3) Kinerja Pegawai di Kantor Dinas Pertanian Kabupaten Merauke sudah sangat baik, hal ini harus tetap dipertahankan jikalau perlu lebih ditingkatkan lagi. Kinerja yang baik menjadi faktor yang terpenting untuk terus di ciptakan dengan baik sehingga dapat memuaskan masyarakat.
Implementasi Kebijakan Pengelolaan Keuangan Kampung Tiworo, Merauke
Authors: Wika Martinus , Tambaip Beatus 
Published: October 2023

Penelitian ini dilakukan untuk menganalisis dan mendeskriptifkan Implementasi Kebijakan Pengelolaan Keuangan Kampung yang dilakukan oleh Pemerintah Kampung Kiworo sejak tahun 2015-2017 dengan total anggaran Rp. 1.400.000.000 (Satu Milyar Empat Ratus Juta Rupiah), namun pengelolaannya masih sangat jauh dari pada harapan. Metode yang di gunakan adalah metode kualitatif juga disesuaikan dengan karakteristik, maka penelitian ini dilakukaan dengan desain penelitian Deskriptif Kualitatif, dengan informan sebanyak 12 Orang yang terdiri dari perangkat Kampung Kiworo termasuk Kepala Kampung, Tokoh-tokoh Masyarakat Kampung dan Kasi Pemerintahan Distrik Kimaam. Berdasarkan hasil penelitian yang dilakukan penulis di Kampung Kiworo terkait judul penulis Implementasi kebijakan pengelolaan keuangan desa di Kampung Kiworo Distrik Kimaam Kabupaten Merauke Provinsi Papua, maka penulis mememukan (1). Terjadinya pengelolaan keuangan kampung yang tidak akuntabel, karena sikap dan perilaku apatis perangkat kampung terhadap rugulasi. mereka senantiasa tidak menjalankan pengelolaan keuangan kampung tidak susuai dengan regulasi sehinga prosesnya tidak berjalan sebagaimana mestinya mulai dari proses perencanaan, pelaksanaan, dan pelaporan serta pengawasan dan evaluasi. (2). adanya beberapa faktor penghambat antara lain minimnya sumber daya manusia, kurangnya komunikasi sikap, dan perilaku perangkat kampung, pola pengelolaan keuangan kampung yang belum maksimal, Kurangnya sarana dan prasarana penunjang, tidak adanya sanksi yang tegas dari pemerintah kabupaten, sehingga upaya untuk melaksakan proses pengelolaan keuangan kampung yang akun tabel sangat sulit di kampung kiworo karena dipengaruhi beberapa faktor diatas. (3). Strategi yang harus dilakukan adalah mengobtimalkan proses pengelolaan keuangan mulai dari perencanaan, pelaksanahan hingga pada pelaporan dan pengawasan dan evaluasi, dengan memanfaatkan regulasi yang ada. Disarankan kepada Pemerintah kampung kiworo, dalam melaksakan proses pengelolaan keuangan kampung wajib mengacu kepada UU No. 06 Tahun 2014 Tentang Desa Tentang Desa dan, Permendagri No. 113 Tentang Pengelolaan Keuangan Desa dan hirarkinya sampai dengan PEDES serta Pemerintah harus memperhatikan upah kerja yang diberikan kepada perangkat desa dan harus ditetapkan dengan aturan-aturan sehingga jelas bagi para perangkat.
Implementasi Kebijakan Program Keluarga Harapan (PKH) Di Desa Gununglurah Kecamatan Cilongok Kabupaten Banyumas
Authors: Sutikno Chamid , Pribadi Indah Ayu Permana , Atika Zaula Rizki , Amanda Ariesta 
Published: October 2023

Penelitian ini membahas mengenai implementasi kebijakan dari pelaksanaan Program Keluarga Harapan di Desa Gununglurah Kecamatan Cilongok Kabupaten Banyumas. Program keluagra harapan (PKH) merupakan program pemerintah dalam hal peningkatan kesejahteraan masyarakat dalam bidang ekonomi, pendidikan dan peningkatan produktivitas pemberdayaan bagi masyarakat secara berkelanjutan. Metode dalam penelitian ini menggunakan deskriptif melalui pendekatan kualitatif, yang menggambarkan suatu masalah dalam penelitian berdasarkan jawaban dari masalah tersebut. Adapun teknik pengumpulan data yang digunakan dalam penelitian ini yaitu: wawancara, observasi dan dokumentasi. Untuk menguji keabsahan data peneliti menggunakan teknik triangulasi sumber yaitu dengan cara mengecek data yang telah diperoleh melalui beberapa sumber. Penelitian ini dilakukan dengan pendekatan teori implementasi kebijakan publik dengan melihat aspek kebijakan yang ideal, kelompok sasaran, organisasi pelaksana dan faktor lingkungan yang mempengaruhi pelaksanaan implementasi kebijakan. Dari hasil penelitian diketahui bahwa Implementasi kebijakan dalam pelaksanaan program keluarga harapan secara umum dapat berjalan berjalan sesuai dengan ketentuan dan kebijakan yang ada. Perlunya upaya dan strategi pada pelaksanaan program keluarga harapan dari berbagai stakeholders agar pencapaian tujuan dari pelaksanaan program tercapai secara sistematis. Program kelurga harapan yang saat ini dilaksanakan saat ini sudah mampu meningkatan pemberdayaan ekonomi masyarakat, khususnya masyarakat dengan penghasilan rendah agar secara bertahap berdaya dalam pemenuhan kebutuhan hidup sesuai standar kelayakan.
Perbandingan Kebijakan Laju Pertumbuhan Penduduk Di Indonesia Dan Korea Selatan
Authors: Hidayatulloh Wahid , Kurniasih Denok 
Published: October 2023

Abstract: The problem faced by developing countries like Indonesia is the baby bomb. In Indonesia, the population explosion was felt in the late 1960s. In contrast to Indonesia, Korea has a low population growth rate. Korea has one of the lowest fertility rates in the world, and a steady decline in fertility rates has been observed since the late 20th century. The total fertility rate in Korea declined rapidly from 1.74 in 1984 to 1.08 in 2005 and then, surprisingly, fell to a level of 0.92 in 2019. The Family Planning (KB) program as a national movement. Meanwhile, the policies adopted by the Korean government in overcoming the declining birth rate are policies that focus on three areas:

Expanding support for child care and education costs, and expanding after school education.
Providing various incentives for families with children strengthens support for adopting families: expands child care facilities and workplaces. Improve the quality of services in private child care facilities, and expand child care services to meet diverse demands.
Building health and nutrition systems, providing economic support for couples who suffer from infertility, and assistance for postnatal baby care from poor class.

Abstrak: Masalah yang dihadapi negara berkembang seperti di Indonesia yaitu baby bom. Di Indonesia ledakan penduduk sangat terasa di akhir tahun 1960-an. Berbeda dengan Indonesia, di Korea laju pertumbuhan penduduknya rendah. Korea memiliki salah satu tingkat kesuburan terendah di dunia, dan penurunan tajam dalam tingkat kesuburan telah diamati sejak akhir abad ke-20. Tingkat kesuburan total di Korea menurun dengan cepat dari 1,74 pada tahun 1984 menjadi 1,08 pada tahun 2005 dan kemudian, secara mengejutkan, turun ke level 0,92 pada tahun 2019. Kebijakan yang diambil pemerintah Indonesia untuk mengatasi masalah pertumbuhan penduduk yaitu Mencanangkan program Keluarga Berencana (KB) sebagai gerakan nasional. Sedangkan Kebijakan yang diambil oleh pemerintah Korea dalam mengatasi penurunan angka kelahiran yaitu dengan kebijakan yang berfokus pada tiga bidang:

Memperluas dukungan untuk biaya perawatan dan pendidikan anak, dan memperluas pendidikan setelah sekolah.
Pemberian berbagai insentif bagi keluarga yang memiliki anak; memperkuat dukungan bagi keluarga yang mengadopsi; memperluas fasilitas penitipan anak dan tempat kerja, meningkatkan kualitas layanan di fasilitas penitipan anak swasta, dan memperluas layanan penitipan anak untuk memenuhi tuntutan yang beragam.
Membangun sistem kesehatan dan gizi, memberikan dukungan ekonomi bagi pasangan yang menderita infertilitas, dan bantuan untuk perawatan bayi pasca persalinan dari kelas miskin.