bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autograft augmentation with compressed long head of the biceps tendon for large rotator cuff tears
Authors: Estfeller Andrea , Lanz Ulrich 
Published: January 2025

Abstract
Autologous augmentation using a compressed stump of the long head of the biceps tendon (LHBT) offers a promising approach for treating large rotator cuff tears (LRCT). This case report highlights the successful application of this technique. A 77-year-old active female presented with right shoulder pain and restricted mobility. Initial MRI revealed multiple injuries, including a complete supraspinatus tear and a partial infraspinatus rupture. Following arthroscopic rotator cuff repair, subacromial decompression, and suprapectoral tenodesis of the LHBT, the remaining stump was used as an augmentation patch for the supraspinatus tendon. Six months postoperatively, the patient demonstrated full, pain-free mobility and successful patch integration. This case underscores the potential of the LHBT as an autologous graft to enhance healing and stability in LRCT. As a promising technique, LHBT augmentation could provide an effective solution for managing large rotator cuff tears, particularly in patients at high risk of retear.
Unusual Association of Partial Fanconi Syndrome and Tumor-Induced Osteomalacia Revealed by Multiple Vertebral Fractures
Authors: Debrach Anne-Cécile , Coen Matteo , De Seigneux Sophie , Saiji Essia , Boudabbous Sana , Willi Jean-Pierre , Serratrice Jacques , Genevay Stéphane , Biver Emmanuel 
Published: January 2025

Abstract
Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome caused by a mesenchymal tumor secreting a phosphaturic hormone called FGF23. Patients present with bone pain, fragility fractures and muscle weakness. Biochemical results show hypophosphatemia, raised serum alkaline phosphatase and reduced calcitriol. We report the case of a 44-year-old man who presented to the Emergency Departement with acute low back pain revealing extensive subchondral fractures between D2 and L5. Investigations showed partial Fanconi syndrome; nevertheless, he had profound hypophosphatemia, low 1,25-OH vitamin D and raised FGF23 levels suggesting a diagnosis of tumor-induced osteomalacia. A subcutaneous lesion was identified in the left leg on a PET-CT initially performed to rule out malignancy in the context of Fanconi syndrome. Tumorectomy enabled complete resolution of the electrolyte disturbances within days of surgery. This case shows that TIO may present as partial Fanconi syndrome, highlighting the importance of testing other electrolytes in cases of hypophosphatemia and the need to look for TIO in cases of partial Fanconi with severe hypophosphatemia.
Imaging biomarkers of cortical neurodegeneration underlying cognitive impairment in Parkinson’s disease
Authors: Silva-Rodríguez Jesús , Labrador-Espinosa Miguel Ángel , Castro-Labrador Sandra , Muñoz-Delgado Laura , Franco-Rosado Pablo , Castellano-Guerrero Ana María , Macías-García Daniel , Jesús Silvia , Adarmes-Gómez Astrid D. , Carrillo Fátima , Martín-Rodríguez Juan Francisco , García-Solís David , Roldán-Lora Florinda , Mir Pablo , Grothe Michel J. 
Published: January 2025

Abstract

Purpose
Imaging biomarkers bear great promise for improving the diagnosis and prognosis of cognitive impairment in Parkinson’s disease (PD). We compared the ability of three commonly used neuroimaging modalities to detect cortical changes in PD patients with mild cognitive impairment (PD-MCI) and dementia (PDD).

Methods
53 cognitively normal PD patients (PD-CN), 32 PD-MCI, and 35 PDD underwent concurrent structural MRI (sMRI), diffusion-weighted MRI (dMRI), and [18F]FDG PET. We extracted grey matter volumes (sMRI), mean diffusivity (MD, dMRI), and standardized uptake value ratios ([18F]FDG PET) for 52 cortical regions included in a neuroanatomical atlas. We assessed group differences using ANCOVA models and further applied a cross-validated machine learning approach to identify the modality-specific brain regions that are most indicative of dementia status and assessed their diagnostic accuracy for group separation using receiver operating characteristic analyses.

Results
In sMRI, atrophy of temporal and posterior-parietal areas allowed separating PDD from PD-CN (AUC = 0.77 ± 0.07), but diagnostic accuracy was poor for separating PD-MCI from PD-CN (0.57 ± 0.10). dMRI showed most pronounced diffusivity changes in the medial temporal lobe, which provided excellent diagnostic performance for PDD (AUC = 0.87 ± 0.06), and a more modest but still significant performance for PD-MCI (AUC = 0.71 ± 0.09). Finally, [18F]FDG PET revealed pronounced hypometabolism in posterior-occipital regions, which provided the highest diagnostic accuracies for both PDD (AUC = 0.89 ± 0.05) and PD-MCI (AUC = 0.78 ± 0.05). In statistical comparisons, both [18F]FDG PET (p < 0.001) and dMRI (p < 0.031) outperformed sMRI for detecting PDD and PD-MCI.

Conclusion
Among the tested modalities, [18F]FDG PET was most accurate for detecting cortical changes associated with cognitive impairment in PD, especially at early stages. Diffusion measurements may represent a promising MRI-based alternative.
Biomarker microRNA-371a-3p - expression in malignancies other than germ-cell tumours
Authors: Belge Gazanfer , Klemke Markus , Hansen Bendix , Dumlupinar Cansu , Igde Aylin , Arnold Dirk , Salwender Hans , Wülfing Christian , Soave Armin , Dieckmann Klaus-Peter 
Published: January 2025

Abstract

Purpose
microRNA-371a-3p (M371) is considered a highly sensitive and specific serum biomarker of testicular germ cell tumours (GCTs). However, little is known about the expression of M371 in nontesticular malignancies (NTMs), so far. As knowledge about the expression of the marker in other malignancies is a prerequisite for the clinical application of the test we aimed to explore the M371 expression in other cancers.

Methods
M371 serum levels were measured in 137 patients with NTM of 12 different neoplastic entities using the IVDR-certified M371-Test for quantitative real-time PCR. Median M371 serum levels and percentages of M371 level elevations were calculated for the entire NTM group and for entity-specific subgroups. The results were compared with GCT patients (n = 20) and with tumour-free male controls (n = 20) using descriptive statistical methods.

Results
Eight patients with NTMs had M371 serum level elevations, corresponding to a false-positive rate (FPR) of 5.84% (95% confidence intervals (CIs) 2.55–11.18%). Expression rates in GCTs and controls were 100% and zero, respectively. Thus, the specificity of the M371-Test for GCT is 94.90% (95% CI 90.21–97.77%) when all NTMs and tumour-free controls are considered. Remarkably, three out of 5 patients with multiple myeloma had elevated M371 levels.

Conclusion
The false-positive rate of the M371-Test in other malignancies than GCT is very low, and almost identical with that in healthy males, corresponding to a high specificity of 94.9% for detection of GCT. The surprising finding of M371 elevations in patients with multiple myeloma needs further investigation.
Production of clean-label starch using physically treated starch blending and its application as a xanthan gum substitute
Authors: Park Shinjae , Kim Yong-Ro 
Published: January 2025

Abstract
This study explores clean-label starch as a functional alternative to xanthan gum in food applications. The optimal blending ratio of ultrasound-treated rice and potato starch was found to be 25:75, resulting in a product with enhanced stability and viscosity similar to xanthan gum. A mathematical model was developed to adjust the viscosity of clean-label starch to match xanthan gum at various concentrations and shear rates, showing high predictive accuracy (R2 = 0.988). The clean-label starch was then tested in food applications, including as a thickener in tomato ketchup. In ketchup, samples with added clean-label starch exhibited similar serum separation and viscosity reduction as those with xanthan gum. Overall, clean-label starch shows strong potential as a functional, clean-label alternative to xanthan gum, offering both economic and nutritional benefits in food products.
In vitro evaluation of dye penetration and dentin microhardness after laser irradiation using photon-induced photoacoustic streaming and shock wave enhanced emission photoacoustic streaming tips compared to ultrasonic activation
Authors: Mobarak Ahmed Moustafa , Ibrahim Yomna Mohamed , Abdelhakim Ahmed Adel , Arnabat-Dominguez Josep , El Backly Rania Mahmoud 
Published: January 2025

Abstract
The purpose of this study was to compare the penetration of methylene blue (MB) dye after laser irradiation using PIPS (photon-induced photoacoustic streaming) and SWEEPS (shockwave enhanced emission photoacoustic streaming) methods compared to Passive ultrasonic irrigation (PUI) and to study their effect on dentin microhardness. A total of 44 single-rooted human teeth which were extracted for orthodontic or periodontal reasons were used. The teeth were decapitated to standardize roots to 12 mm in length. Canals were prepared up to size #30.6% and divided randomly into four groups (n = 11/group) according to the method of NaOCl activation: Group I: Er: YAG laser activation with PIPS tip; Group II: Er: YAG laser activation with SWEEPS tip; Group III: passive ultrasonic irrigation (PUI) and Group IV: conventional needle irrigation (CI). MB dye was injected then teeth were sectioned horizontally into coronal, middle and apical sections. Penetration depth/area percentages were measured using stereomicroscopy. Coronal specimens were further subjected to Vickers microhardness testing. Data were statistically analyzed. SWEEPS and PIPS activation methods provided higher dye penetration depth and area percentages compared to PUI with no statistically significant differences between all test groups. However, all test groups showed statistically significant differences with the CI (control) group. SWEEPS activation provided higher microhardness values with statistically significant differences with the other groups. Laser irrigant activation using PIPS and SWEEPS is comparable to PUI concerning MB dye penetration. However, SWEEPS preserved dentin microhardness significantly which can be beneficial for the long-term prognosis of root canal treated teeth.
Interparental Relationship Discord and Adolescent Psychopathology in a United States Probability Sample
Authors: Stern Elisa F. , Rhee Soo Hyun , Whisman Mark A. 
Published: January 2025

Abstract
Exposure to interparental conflict and poor parental relationship adjustment (i.e., interparental relationship discord) has been associated with children’s internalizing and externalizing symptoms throughout childhood and later life. However, the degree to which interparental relationship discord is associated with clinical levels of psychopathology in adolescents remains unclear. The association between parents’ report of interparental relationship discord and mental disorders in adolescents was investigated in the National Comorbidity Survey–Adolescent Supplement, a United States probability sample of 13-17-year-old adolescents and their parents (N = 4,112 dyads). A hierarchical framework, consisting of 16 specific disorders, latent dimensions of internalizing and externalizing disorders, and a latent dimension of general psychopathology, was employed. Greater interparental relationship discord demonstrated small but significant associations with higher levels of general psychopathology and internalizing and externalizing psychopathology, as well as with several specific disorders. Overall, results are consistent with the perspective that interparental relationship discord may increase risk for clinical levels of psychopathology in adolescents.
Mitochondria Express Functional Signaling Ligand-Binding Receptors that Regulate their Biological Responses – the Novel Role of Mitochondria as Stress-Response Sentinels
Authors: Brzezniakiewicz-Janus Katarzyna , Jarczak Justyna , Konopko Adrian , Ratajczak Janina , Kucia Magdalena , Ratajczak Mariusz Z. 
Published: January 2025

Abstract
Evidence accumulated mitochondria, as the “powerplants of the cell,” express several functional receptors for external ligands that modify their function and regulate cell biology. This review sheds new light on the role of these organelles in sensing external stimuli to facilitate energy production for cellular needs. This is possible because mitochondria express some receptors on their membranes that are responsible for their autonomous responses. This is not surprising given the widely accepted hypothesis that these intracellular organelles originated from prokaryotic ancestors that fused with eukaryotic cells during early evolution. It has been reported that mitochondria express functional estrogen, androgen, glucocorticoid, 5-hydroxytryptamine, melatonin, and cannabinoid receptors. What is intriguing is recent evidence showing that mitochondria could also be directly regulated by active mediators of intracellular complement (complosome) and intrinsic mediators of purinergic signaling. Accordingly, they express receptors for intracellular complement cleavage fragments (C5a and C3a) as well as for adenosine triphosphate (ATP), which, besides its crucial role in transferring energy in the cells, is also an important signaling molecule interacting with P2X7 receptor expressed not only on the cell surface but also on the mitochondria membrane. Based on this, intrinsic complosome and purinergic signaling mediators emerge as important cooperating regulators of reactive oxygen species (ROS) release from mitochondria and activators of intracellular pattern recognition receptor Nlrp3 inflammasome. This activation within the beneficial “hormetic zone response” regulates cell metabolism, proliferation, migration, and adaptation to the surrounding challenges of the microenvironment in a favorable way.

Graphical Abstract
Organizational compassion: a conceptual extension and scale development
Authors: Akgün Ali E. , Keskin Halit , Etlioğlu Başaran Hatice T. 
Published: January 2025

Abstract
While the concept of compassion has been extensively explored at the individual level, this study takes a new approach by examining the compassion of organizations and, more specifically, the compassion capacity of organizations from an organizational culture perspective. This study develops a unique organizational compassion capacity scale through four field studies using an exploratory sequential mixed-methods research design. The findings unveil that organizational compassion capacity is a multi-dimensional construct with five dimensions: noticing, feeling, responding, collective action, and resource usage-related culture. This study further discusses the theoretical and practical implications of the findings.
Effectiveness of online education on thermography-based diabetic foot ulcer prevention for wound care specialists: a single-group quasi-experimental study
Authors: Aminuddin Muhammad , Sukarni  , Haryanto  , Jais Suriadi , Yamada Amika , Mukai Kanae , Oe Makoto 
Published: January 2025

Abstract

Background
While there is an urgent need worldwide to establish methods that prevent diabetic foot ulcers, the effectiveness of a prevention protocol using thermography has been reported. As the number of diabetic patients in Indonesia is increasing, an online program for wound care specialists was developed to disseminate this protocol. The present study evaluated the impact of an online program on wound care specialists' knowledge of diabetic foot ulcer prevention using thermography.

Methods
This single-group quasi-experimental study was conducted in cooperation with the Indonesian Wound Enterostomal Continence Nurses Association with regard to curriculum and content design, and the evaluation methods of online education for thermography-based diabetic foot ulcer prevention using the learning management system. A questionnaire with 50 multiple-choice questions previously validated for content and readability on the knowledge of diabetic foot ulcer prevention using thermography was used for training evaluations.

Results
Of 106 Indonesian wound care specialists evaluated, the paired t-test revealed a significant difference between the before and after training questionnaire scores on knowledge (52.0 ± 10.3, 85.2 ± 10.6, respectively, p < 0.001). Repeated measures analysis of variance revealed interactions between time (before and after training) and gender, and between time and type of certificate (p = 0.046, p = 0.014, respectively).

Conclusions
An asynchronous e-learning program is an effective method to increase wound care specialists' knowledge of diabetic foot ulcer prevention. These findings suggest that online educational interventions are effective and can be tailored to meet the needs of healthcare professionals, thereby ultimately contributing to better patient care outcomes in preventing DFUs.
Atomically Dispersed Metal Atoms: Minimizing Interfacial Charge Transport Barrier for Efficient Carbon-Based Perovskite Solar Cells
Authors: Shi Yanying , Cheng Xusheng , Wang Yudi , Li Wenrui , Shang Wenzhe , Liu Wei , Lu Wei , Cheng Jiashuo , Liu Lida , Shi Yantao 
Published: January 2025

Abstract
Carbon-based perovskite solar cells (C-PSCs) exhibit notable stability and durability. However, the power conversion efficiency (PCE) is significantly hindered by energy level mismatches, which result in interfacial charge transport barriers at the electrode-related interfaces. Herein, we report a back electrode that utilizes atomically dispersed metallic cobalt (Co) in carbon nanosheets (Co1/CN) to adjust the interfacial energy levels. The electrons in the d-orbitals of Co atoms disrupt the electronic symmetry of the carbon nanosheets (CN), inducing a redistribution of the electronic density of states that leads to a downward shift in the Fermi level and a significantly reduced interfacial energy barrier. As a result, the C-PSCs using Co1/CN as back electrodes achieve a notable PCE of 22.61% with exceptional long-term stability, maintaining 94.4% of their initial efficiency after 1000 h of continuous illumination without encapsulation. This work provides a promising universal method to regulate the energy level of carbon electrodes for C-PSCs and paves the way for more efficient, stable, and scalable solar technologies toward commercialization.
BNE, aber wie?! Explorative Einblicke in die Motivationen und Erwartungshaltungen von erwachsenen Lernenden
Authors: Otremba Katrin Mareike 
Published: January 2025

Zusammenfassung
Mittels Bildung für nachhaltige Entwicklung soll die Transformation zu einer nachhaltigen Gesellschaft gelingen. Dazu sollen alle Lernenden bis 2030 die für eine nachhaltige Entwicklung notwendigen Kompetenzen erwerben. Im bildungspolitischen und -wissenschaftlichen Diskurs werden Erwachsene jedoch selten als eigenständige Zielgruppe von BNE-Angeboten adressiert oder im Rahmen von Forschungsprojekten genauer in den Blick genommen. Anhand quantitativer Daten nähert sich der Beitrag erwachsenen Lernenden im Kontext von BNE an und arbeitet ihre Interessenlagen und Erwartungshaltungen an BNE-Angebote heraus. Letztere sind für eine zielgruppenorientierte Angebotsausgestaltung zentral. Clusteranalysen verdeutlichen, dass die Interessen und Erwartungshaltungen innerhalb der Zielgruppe differieren.
The spread of an epidemic: a game-theoretic approach
Authors: Karmakar Sayar , Podder Moumanti , Roy Souvik , Sadhukhan Soumyarup 
Published: January 2025

Abstract
We introduce and study a game-theoretic model to understand the spread of an epidemic in a homogeneous population. A discrete-time stochastic process is considered where, in each epoch, first, a randomly chosen agent updates their action trying to maximize a proposed utility function, and then agents who have viral exposures beyond their immunity get infected. Our main results discuss asymptotic limiting distributions of both the cardinality of the subset of infected agents and the action profile, considered under various values of two parameters (initial action and immunity profile). We also show that the theoretical distributions are almost always achieved in the first few epochs.
Ethical Oversight and Social Licensing of Portable MRI Research
Authors: Evans Barbara J. 
Published: January 2025

AbstractThis article explores two questions: (1) whether portable MRI research might escape regulatory oversight altogether under existing U.S. privacy and research ethical frameworks, leaving research participants without adequate protections, and (2) whether existing regulatory frameworks, when they do apply, can guard society’s broader interest in ensuring that portable MRI research pursues socially beneficial, ethically sound aims that minimize the potential for externalities affecting nonparticipating individuals and groups, who might be stigmatized or otherwise harmed even if they decline participation in the research.
Socioeconomic Factors in Brain Research: Increasing Sample Representativeness with Portable MRI
Authors: Farah Martha J. 
Published: January 2025

AbstractPeople of low socioeconomic status (SES) are often underrepresented in biomedical research. The importance of demographically diverse research samples is widely recognized, especially given socioeconomic disparities in health, but have been challenging to achieve. One barrier to research participation by low SES individuals is their distance from research centers and the difficulty of traveling. This article examines the promise of portable magnetic resonance imaging (pMRI) for enrolling participants of diverse SES in structural neuroimaging studies, and anticipates some of the challenges, practical and ethical, that may arise in the course of such research.
Higher-order motivational constructs as personal-level fictions: A solution in search of a problem
Authors: Jurjako Marko 
Published: January 2025

Abstract
I argue that Murayama and Jach's claim that higher-order motivational constructs face the “black-box” problem is misconceived because it doesn't clearly distinguish between personal and subpersonal explanations. To solve it they propose interpreting motivations as causal effects of mental computational processes. I suggest that their solution might be more compellingly presented as providing a fictionalist perspective on some personal-level constructs.
Exploring novelty to unpack the black-box of motivation
Authors: Bunzeck Nico , Haesler Sebastian 
Published: January 2025

Abstract
Murayama and Jach point out that we do not sufficiently understand the constructs and mental computations underlying higher-order motivated behaviors. Although this may be generally true, we would like to add and contribute to the discussion by outlining how interdisciplinary research on novelty-evoked exploration has advanced the study of learning and curiosity.
Human motivation is organized hierarchically, from proximal (means) to ultimate (ends)
Authors: Dubourg Edgar , Chambon Valérian , Baumard Nicolas 
Published: January 2025

Abstract
Murayama and Jach raise a key problem in behavioral sciences, to which we suggest evolutionary science can provide a solution. We emphasize the role of adaptive mechanisms in shaping behavior and argue for the integration of hierarchical theories of goal-directed cognition and behavioral flexibility, in order to unravel the motivations behind actions that, in themselves, seem disconnected from adaptive goals.