bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supraglottic Jet Oxygenation and Ventilation Improves Oxygenation During Endoscopic Retrograde Cholangiopancreatography: A Randomized Controlled Clinical Trial
Authors: Su Dan , Zhang Wei , Li Jingze , Tan Xi , Wei Huafeng , Wang Yinglin , Ji Zhonghua 
Published: November 2023

Abstract
Purpose
Hypoxia is one of the most frequent adverse events under deep sedation in the semiprone position. We hypothesized that supraglottic jet oxygenation and ventilation (SJOV) via Wei nasal jet tube (WNJ) can reduce the incidence of hypoxia in patients under deep sedation during endoscopic retrograde cholangiopancreatography (ERCP).
Methods
A total of 171 patients were divided into three groups: N group, supplementary oxygen via a nasopharyngeal airway (4–6 L/min); W group, supplementary oxygen via WNJ (4–6 L/min); WS group, SJOV via WNJ. The primary outcome was the incidence of adverse events, including sedation-related adverse events [SRAEs, hypoxemia (SpO2 = 75–89% lasted less than 60 s); severe hypoxemia (SpO2 < 75% at any time or SpO2 < 90% lasted more than 60 s] and subclinical respiratory depression (SpO2 = 90–95%). Other intraoperative and post-operative adverse events were also recorded.
Results
Compared with the N group, the incidence of hypoxemia and subclinical respiratory depression in the WS group was significantly lower (21% vs. 4%, P = 0.005; 27% vs. 6%, P = 0.002). Compared with Group W, the incidence of hypoxemia and subclinical respiratory depression in Group WS was also significantly less frequent (20% vs. 4%, P = 0.009; 21% vs. 6%, P = 0.014). No severe hypoxia occurred in the group WS, while four and one instances were observed in the group N and group W respectively. There were no significant differences in other adverse events among the three groups.
Conclusion
SJOV can effectively improve oxygenation during ERCP in deeply sedated semiprone patients.
PHGDH/SYK: a hub integrating anti-fungal immunity and serine metabolism
Authors: Chen Ai-Dong , Zhang Xinyong , Hu Dongdong , Sun Xiaoyan , Gu Yichun , Zhou Yong , Su Chuanxin , Liu Shi , Zhang Caiyan , Lu Guoping , Wu Qiwen , Chen Ai-Dong 
Published: November 2023

Abstract

During fungal infection, immune cells adapt their metabolic programs to support specialized anti-fungal effector functions. Nevertheless, the role of this process’s biochemical underpinnings is poorly understood. This study reports that fungal infection drives a switch from glycolysis to the serine synthesis pathway (SSP) and one-carbon metabolism by inducing the interaction of spleen tyrosine kinase (SYK) and phosphoglycerate dehydrogenase (PHGDH). As a result, PHGDH promotes SYK phosphorylation, leading to the recruitment of SYK to C-type lectin receptors (CLRs). The CLR/SYK complex initiates signaling cascades that lead to transcription factor activation and pro-inflammatory cytokine production. SYK activates SSP and one-carbon metabolism by inducing PHGDH activity. Then, one-carbon metabolism supports S-adenosylmethionine and histone H3 lysine 36 trimethylation to drive the production of pro-inflammatory cytokines and chemokines. These findings reveal the crosstalk between amino acid metabolism, epigenetic modification, and CLR signaling during fungal infection.
Effect of interaction of ATG7 and plasma heavy metal on cognitive impairment in rural China
Authors: Tang Xu , Cao Jiejing , Cai Jiansheng , Mo Xiaoting , Wei Yanfei , He Kailian , Ye Zeyan , Liang YuJian , Zhao Linhai , Qin Lidong , Li You , Qin Jian , Zhang Zhiyong 
Published: November 2023

Abstract
Objective
To analyze the relationship between the concentration of heavy metals in plasma and the occurrence of cognitive dysfunction using multiple models.
Methods
A cross-sectional survey was conducted in rural China among 961 individuals aged 50 years or older. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Genetic analysis focused on two single nucleotide polymorphisms (SNPs) in the autophagy-related gene ATG7 (rs2606757 and rs8154). Plasma concentrations of heavy metals were quantified using inductively coupled plasma mass spectrometry. Restricted cubic splines were used to explore the association between serum metal concentration and the occurrence of mild cognitive impairment in populations of various genotypes. Bayesian Kernel Machine Regression(BKMR) models were used to explore the interactions between individual metals.
Results
In a restricted cubic spline model, there is a nonlinear relationship between plasma concentration of Cd and the occurrence of cognitive impairment in populations carrying the population carrying AA(P of Nonlinear = 0.036) and AT( P of Nonlinear = 0.027) genotypes at the rs2606757. However, in people carrying the TT genotype at the rs2606757 locus, the concentration of heavy metals in plasma was not significantly associated with the occurrence of cognitive impairment. The results of the BKMR model are consistent with those of the restricted cubic spline.
Conclusion
The TT genotype at rs2606757 in ATG7 appears to confer greater cognitive resilience against heavy metal-induced damage. These findings highlight the importance of considering gene-environment interactions in the context of cognitive impairment and suggest potential avenues for preventing cognitive decline in populations exposed to heavy metals. Further research is needed to elucidate the precise mechanisms underlying these interactions.
Beyond power density: unexpected scaling laws in scale up of characterization of reverse-electro-dialysis membranes
Authors: Tregouet Corentin , Colin Annie , Derkenne Timothee 
Published: November 2023

Abstract
Blue energy represents a large reservoir of renewable osmotic energy that can be converted into electricity by reverse electrodialysis (RED). This method is based on ion-exchange membrane. Before large scale production, these membranes are compared on very small samples on the basis of the power they enable to produce per unit area. Through a systematic study of the effect of the membrane size on the power density, we show experimentally that for classical measurement cells, the power density strongly varies with the size of the membrane: the smaller the membrane, the higher the power density. The results are explained by a theoretical modeling which describes the effect of the access resistance at the scale of the membrane. Based on this work, a few recommendations are formulated to perform scalable and meaningful measurements of membrane resistance and power density.
Dependence of the pharmaceutical concentrations in the Warta River water (Poland) on successive waves of COVID-19 pandemic
Authors: Kruć-Fijałkowska Roksana , Drożdżyński Dariusz , Matusiak Magdalena , Dragon Krzysztof 
Published: November 2023

Abstract
Rivers are the recipient of treated sewage discharged into the environment. The study examined the presence of pharmaceuticals in the Warta River at places exposed and non-exposed to the impact of sewage treatment plants. Three sampling points were investigated: near to the outflow of treated sewage, upstream, and downstream the treated sewage outflow. Between February 2020 and April 2021, 13 sampling series were carried out during which 10 pharmaceuticals were determined in river. At the sampling point upstream the treated sewage outflow, the lowest concentrations of pharmaceuticals were determined. A significant increase in concentrations was noted near to the outflow of treated sewage from the treatment plant, then the concentration decreased again. This indicated that the source of pharmaceuticals in the river is the outlet of treated sewage. Furthermore, the research was conducted during the COVID-19 pandemic. It was noticed that the increase in the concentration of pharmaceuticals in the river overlaps with successive waves of the COVID-19 pandemic in Poland. During tightening restrictions, the consumption of preventive and psychotropic drugs increases, associated with worse physical and mental well-being and the desire to protect against the virus. The consumption of prescription drugs decreases, linked to more difficult access to doctors.
Comparison of Warm Sitz Bath and Electronic Bidet with a Lower-Force Water Flow for Postoperative Management after Hemorrhoidectomy (BIDLOW)
Authors: Kwon Yoon-Hye , Ryoo Seung-Bum , Oh Heung-Kwon , Lee Jae Bum , Jung Hyung-Joong , Song Kee-Ho , Heo Seung Chul , Shin Rumi , Lee Joongyub , Park Kyu Joo 
Published: November 2023

Abstract
Electronic bidets can be a substitute for sitz baths, but no study has examined the use of electronic bidets to manage anal problems. A randomized, controlled, single-blind, multicenter, parallel group trial was performed. Patients who underwent hemorrhoidectomy were randomly assigned (1:1) to use the electronic bidet or warm sitz baths for 7 days after hemorrhoidectomy. The primary endpoint was the difference in the anal pain VAS score for 7 days posthemorrhoidectomy. Patients were assigned to the electronic bidet (51) or sitz bath (50) groups. Twenty-six patients dropped out after randomization, and the final analysis included 34 patients in the electronic bidet group and 41 in the sitz bath group. The VAS score for anal pain 7 days posthemorrhoidectomy did not differ between the electronic bidet and sitz bath groups (38.3 ± 21.9 vs 42.0 ± 21.1, p = 0.453). The upper limit of the 95% confidence interval of the VAS score in the electronic bidet group (81.22) was greater than the margin of noninferiority (46.20). The VAS scores after hemorrhoidectomy did not differ between the electronic bidet and sitz bath groups, but the noninferiority of the electronic bidet to sitz baths for anal pain 7 days posthemorrhoidectomy was not verified.
Trends in socio-demographic characteristics and substance use among high school learners in a selected district in Limpopo Province, South Africa
Authors: Shuro Linda , Waggie Firdouza 
Published: November 2023

Abstract
Background
Substance use is an escalating public health problem in South Africa resulting in risky behaviours and poor educational attainment among adolescents. There is a huge battle to overcome substance use among learners as more drugs become easily available with the mean age of drug experimentation reported to be at 12 years of age. It is important to continuously understand the trends in substance use in order to assess if there are positive changes and provide evidence for development of effective interventions. This paper outlines the prevalence of substance use among selected high schools in Limpopo province.
Methods
To determine the prevalence of substance use among selected high school learners in Capricorn district, Limpopo Province, a cross-sectional school survey of 768 learners was conducted. Data was analysed using SPSS v 26. Descriptive analysis was used to describe the independent and dependent variables and Chi-Square test was used to investigate associations between demographic characteristics and substance use among high school learners.
Results
The most abused substances by learners were alcohol (49%), cigarettes (20.8%) and marijuana (dagga/cannabis) (16.8%). In a lifetime, there was a significant difference (P < 0.05) in cigarette smoking with gender, school, and grade; with more use in males (14.2%) than females (7.6%); in urban schools (14.6) than peri-urban (6.7%) and more in Grade 12 (6.4%). There was a significant difference (P < 0.05) in alcohol use with more use in Grade 10 (12.6%) and varied use among male and female learners but cumulatively more in females (27.7%). Drug use varied, with an overall high drug use in urban schools (20.7%).
Conclusions
Substance use is rife among high school learners in the district and health promotion initiatives need to be tailored within the context of socio-demographic characteristics of learners including the multiple levels of influence such as peer pressure, poverty, unemployment and child headed families. Additional research is required to investigate the factors leading to a notable gradual increase in use among female learners and into the environmental and family settings of learners in influencing drug abuse.
Increasing access to fertility preservation for women with breast cancer: protocol for a stepped-wedge cluster randomized trial in France
Authors: Addamiano Maria-Claudia , Joannès Camille , Fonquerne Leslie , Morel Charlotte , Lauzeille Delphine , Belkadi Lorène , Empereur Fabienne , Grosclaude Pascale , Bauvin Eric , Delpierre Cyrille , Lamy Sébastien , Durand Marie-Anne 
Published: November 2023

Abstract
Background
With the increase in the number of long-term survivors, interest is shifting from cancer survival to life and quality of life after cancer. These include consequences of long-term side effects of treatment, such as gonadotoxicity. Fertility preservation is becoming increasingly important in cancer management. International recommendations agree on the need to inform patients prior to treatments about the risk of fertility impairment and refer them to specialized centers to discuss fertility preservation. However, the literature reveals suboptimal access to fertility preservation on an international scale, and particularly in France, making information for patients and oncologists a potential lever for action. Our overall goal is to improve access to fertility preservation consultations for women with breast cancer through the development and evaluation of a combined intervention targeting the access and diffusion of information for these patients and brief training for oncologists.
Methods
Firstly, we will improve existing information tools and create brief training content for oncologists using a qualitative, iterative, user-centred and participatory approach (objective 1). We will then use these tools in a combined intervention to conduct a stepped-wedge cluster randomized trial (objective 2) including 750 women aged 18 to 40 newly treated with chemotherapy for breast cancer at one of the 6 participating centers. As the primary outcome of the trial will be the access to fertility preservation counselling before and after using the combined intervention (brochures and brief training for oncologists), we will compare the rate of fertility preservation consultations between the usual care and intervention phases using linear regression models. Finally, we will analyse our approach using a context-sensitive implementation analysis and provide key elements for transferability to other contexts in France (objective 3).
Discussion
We expect to observe an increase in access to fertility preservation consultations as a result of the combined intervention. Particular attention will be paid to the effect of this intervention on socially disadvantaged women, who are known to be at greater risk of inappropriate treatment. The user-centred design principles and participatory approaches used to optimize the acceptability, usability and feasibility of the combined intervention will likely enhance its impact, diffusion and sustainability.
Trial registration:
Registry: ClinicalTrials.gov
Trial registration number: 2022-057
Date of registration: 7th September 2023
URL: https://classic.clinicaltrials.gov/ct2/show/NCT05989776
Protocol version:
Manuscript based on study protocol version 2.0, 21st may 2023.
Transboundary Particulate Matter Pollution and the Environmental Kuznets Curve in Korea
Authors: bak yuhyeon , Teshigawara Tsurue , Yoon Taeyean , Lee Yoon 
Published: November 2023

Abstract
Recent studies on the air pollution Environmental Kuznets Curve (EKC) in South Korea imply an N-shaped curve, suggesting the worsening of air pollution in the country. This study aims to test the EKC hypothesis of South Korea by considering China’s transboundary air pollution effect. We estimate EKC for monthly PM10 with the generalized least squares approach using meteorological and economic factors, and China’s effect during 2000–2021. We find that PM10 pollution shows an N-shaped trajectory EKC with turning points at $6,836 and $12,662, suggesting that China’s effect may have played a role in the process of improving and deteriorating air quality in South Korea. We also confirm that major air pollutants (PM10, SO2, and NO2) are cointegrated using the seemingly unrelated regressions (SUR) model. The findings suggest a need for regional cooperation, taking into account the transboundary effects from neighboring countries to mitigate air pollution in a country.
Audio Steganography Algorithm Based On Phase Coding
Authors: Dussan Sofia , Henao Adriana Sofia , Silva María Manuela , Donado Siler Amador 
Published: November 2023

Abstract

Given the exponential growth of data transmission over the Internet, ensuring digital security has emerged as a paramount concern. In response to this, various disciplines, such as steganography, have been developed. Steganography operates on the principle of concealing confidential information within a carrier medium, thereby keeping it hidden from prying eyes. In this study, we present a MATLAB-based steganography algorithm tailored for audio signals as the carrier medium. Leveraging the Fourier Transform, we employ the phase spectrum of the chosen audio signal to embed information. Our approach includes the introduction of five distinct methods within the transformed domain, along with the implementation of one method in the time domain for comparative purposes. These methods are evaluated based on their embeddability and imperceptibility. The assessment of imperceptibility is conducted using both objective and subjective metrics. While the \textit{temporal method} exhibits the highest embedding capability, \textit{methods one, three, and four} excel in terms of imperceptibility, as indicated by objective results. Interestingly, methods three and four demonstrate superior performance in the subjective evaluation.
An in-vitro study of antibacterial, cytocompatibility and physicochemical properties of nanoarchitecture TiO2-ZnO
Authors: Duraisamy Murugesan , Sreekan Srimala , Govindasamy G Ambarasan , Murthe Satisvar Sundera , Appaturi Jimmy Nelson 
Published: November 2023

Abstract

Background: "Across the globe, the persistent and escalating problem of infections spreading in healthcare settings is driven by the increasing resistance of microbes to disinfectants and antibiotics. Among the most alluring technologies to combat this issue are self-cleaning and disinfecting solutions, particularly for use in hospitals, operating rooms, buildings, and even on glass windows."
A nanoarchitecture TiO2-ZnO was synthesized using a sol-gel and peptization method for photocatalytic antibacterial applications. The resultant TiO2-ZnO exhibited a spherical morphology, encompassing particles with a size below 10 nm. The XRD spectrum and the distinct particle boundaries, displays the good crystalline quality of the particles with anatase and wurtzite phase. The nanoarchitecture TiO2-ZnO solution exhibits excellent stability (65 mV) over an extended period of 24 months. The antibacterial characteristic of the nanoarchitecture TiO2-ZnO were tested using clinical strains of K. pneumoniae (ESBL), E. coli (CRE), E. coli (ESBL), E. faecium (VRE), P. aeruginosa (MDR), A. baumanii (MDR), and K. pneumoniae (CRE). The structural characteristic contributes to a high active surface area for photocatalytic reactions, possessing 99.9% disinfectant of all clinical bacterial strain's colonies in 5 minutes exposure time except E. coli strains (CRE and ESBL) which took 30 minutes. The cytocompatibility profile test MTT, clonogenicity and cell proliferation assay were performed using either L929 mouse fibroblasts and V79 cell demonstrated an absence of cytotoxic effects, underscoring the nanostructure's safety features. Given its high antibacterial properties coupled with its non-cytotoxic nature, the nanoarchitecture TiO2-ZnO emerges as a highly promising candidate for a disinfectant coating material for healthcare segments.
Development and validation of the missed intensive nursing care scale
Authors: Yang Li , Zhou Wen , Gao Yan , Wu Taiqin , Zhang Huan , Gan Xiuni 
Published: November 2023

Abstract
Background
Missed nursing care is a pervasive issue in hospitals, nursing homes, and communities, posing a significant threat to patient safety and the quality of nursing care. It has adverse effects on patient satisfaction and the motivation of nursing staff. Understanding the causes and nature of these care omissions in clinical settings is essential for implementing effective interventions. This study aims to develop and validate a tool for assessing missed nursing care in adult intensive care units.
Methods
A literature review, semistructured interviews, and expert consultations conducted via the Delphi method were used to develop the initial scale. Our analysis involved data collected from 400 nurses and employed correlation coefficient analysis, critical ratio assessment, Cronbach's α coefficient evaluation, discrete trend analysis, and factor analysis, which were grounded in both classical test theory and item response theory, allowing us to scrutinize and refine the items in the scale. To validate the scale, we purposively sampled 550 nurses and assessed content validity, structural validity, internal reliability, split-half reliability, and test-retest reliability to ensure the scale's robustness and accuracy.
Results
The Missed Intensive Nursing Care Scale (MINCS) comprises three distinct components. Part A serves to collect general information about the participants. In Part B, the missed care elements are categorized into five domains, following the framework of Maslow's hierarchy of needs theory: physiology, safety, belongingness, esteem, and cognition. Part C is dedicated to detailing the reasons behind missed care, which encompass labor resources, material resources, community factors, and managerial factors. Remarkably, the Cronbach's α coefficient for the MINCS stands at an impressive 0.98, underscoring the scale's exceptional reliability and validity. This demonstrates the scale's effectiveness in measuring missed nursing care while upholding rigorous standards of quality.
Conclusions
The MINCS emerges as a robust and dependable instrument for quantifying instances of missed care within the ICU. Its efficacy makes it a valuable resource for informing the development of strategies aimed at averting and mitigating the adverse effects associated with missed nursing care.
Gender Gap and Impact Analysis in Cardiovascular Research
Authors: Rozenshteyn Diana , Homayouni Hajar 
Published: November 2023

Abstract
The objective of this study is to assess gender inequalities in research publications in the field of heart disease and to examine the influence of these disparities on research success. Our approach employs explainable machine learning models to gauge publication impact, uncovering the key institutional and demographic factors contributing to successful research outcomes, measured by the beneficiaries of the published research. We analyze a database of heart disease research publications funded by the National Institutes of Health (NIH) from 2002 to 2020. Our analysis uncovers gender disparities, particularly a greater presence of male first authors in prominent journals and institutions. Furthermore, works authored by males generally garner more citations and achieve higher NIH funding scores than those by females, highlighting an enduring gender disparity in publication rates and visibility. In conclusion, this study offers crucial insights into the determinants of impactful publications in the field of heart disease research, encompassing institutional affiliations, gender inequalities, journal rankings, and study types.