bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long waves, paradigm shifts, and income distribution, 1929–2010 and afterwards
Authors: Espinosa-Gracia Adrian , Sánchez-Chóliz Julio 
Published: October 2023

AbstractThe way income is distributed in an economy is perhaps the most notable result of its growth patterns. Understanding the joint persistence of economic crises and changes in social inequality since 1929 is considered a great challenge. This paper tries to analyze growth and income distribution in the long run using the concept of long waves, the evolutionary concept of ‘systems’, and empirical information. We conjecture that the social system is in turn an outcome of the co-evolution of four partially autonomous subdomains: (i) technology, characterized by a paradigm whose evolution follows the shape of a ‘Schumpeterian boom’; (ii) the economy or productive system, essentially defined as the succession of intermediate-length fluctuations in investments, and strongly associated to sectoral and structural changes; (iii) science, which contributes to development by generating innovations; and (iv) institutions, which set the rules in which income distribution is framed. Following this scheme, the data reveal that income distribution is an emerging result from this ‘global social system’ and not only the result of economic productivity and technology; apparently, the weight in the income distribution of institutional factors is as relevant as economic and technological factors. Second, the long-run growth trends are most possibly non-linear and, to great extent, non-deterministic, which would support the representation of long-run phenomena as long waves. Finally, we have found that in the long period 1929–2010 and afterwards, two sub-periods are manifested, with very different regimes of income distribution: (1) 1929–1975, when inequality decreased, and (2) from 1975 to present time, when inequality increased. Concerning the years after 2010, two alternatives follow: either these correspond to the recovery phase of a new long wave, or to the end of the depression phase of our second period. In both cases, we are currently moving towards the expansionary phase of a new long wave, which will have important implications for contemporary economic policies.
Combustion models for shock-induced cloud ignition of aluminium particles using smoothed particle hydrodynamics
Authors: Omang M. , Hauge K. O. , Trulsen J. K. 
Published: October 2023

AbstractThe present work is a numerical follow-up on our published experimental paper on shock ignition of aluminium particle clouds in the low-temperature regime. The in-house multi-phase regularized smoothed particle hydrodynamics (MP-RSPH) code is used to perform numerical simulations with an increasing degree of complexity, looking at single-phase, inert, and reactive particles in separate simulations. The first part of the paper gives a short description of the additional physics added to the code. Based on the experimental results, the numerical code is then used to estimate the particle temperature at the time of ignition. Results from simulations with three different numerical descriptions, the diffusive, kinetic, and total burn rates, are then compared to the experimental results. The two diffusive burn rate simulations (K &H and O &H) show the best fit to the experimental results. The burn rate formula based on our experimental data (O &H) is preferred, since it has the gas temperature dependency included and does not require additional parameter adjustments. The results from the numerical simulations support the theory that the observed aluminium particle cloud burning process is diffusive, as indicated in the experimental paper.
A comparison of explosively driven shock wave radius versus time scaling approaches
Authors: Hargather M. J. , Winter K. O. , Kimberley J. , Wei T. 
Published: October 2023

AbstractExplosively driven shock wave radius versus time profiles are frequently used to document energy release and relative explosive performance. Recently, two universal shock wave radius versus time profiles have been presented in the literature, which demonstrate the ability to represent explosively driven shock wave profiles for all explosive sources in any fluid environment. These two universal shock wave profiles are examined here relative to each other and relative to a commonly used nonlinear shock wave profile, which is fit to experimental data for individual explosive materials. The nonlinear profile, originally developed by Dewey, is examined here, and a universal non-dimensional form of the equation is proposed. The universal shock wave profiles are all found to be relatively similar, but with slight variations in a transition region of non-dimensional radii $$0.15\lesssim R^*\lesssim 2$$

0.15
≲

R
∗

≲
2

. The variations in this region result in different estimations of energy release or blast strength between the curve fits.
Two new pygmy squids, Idiosepius kijimuna n. sp. and Kodama jujutsu n. gen., n. sp. (Cephalopoda: Idiosepiidae) from the Ryukyu Islands, Japan
Authors: Reid Amanda , Sato Noriyosi , Jolly Jeffrey , Strugnell Jan 
Published: October 2023

AbstractTwo new pygmy squid from the Ryukyu archipelago, Japan, are described: Kodama jujutsu, n. gen., n. sp. and Idiosepius kijimuna, n. sp. They differ from all other nominal species in a combination of traits, including the number of tentacular club suckers, shape of the funnel-mantle locking-cartilage, modification of the male hectocotylus and the structure of the gladius and nuchal-locking cartilage, in addition to mitochondrial DNA markers (12S, 16S and COI). They are both known from Okinawa Island and there is some overlap in their distributions. In a molecular phylogeny that includes all nominal Idiosepiidae, Kodama jujutsu, n. gen., n. sp. is sister taxon to a clade containing Xipholeptos Reid & Strugnell, 2018 and Idiosepius Steenstrup, 1881. Xipholeptos and Idiosepius are sister taxa. Idiosepius spp. now includes seven nominal species. In addition, aspects of the behaviour of the new species are described.
Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing
Authors: Härkänen Lasse , Hakomäki Henriikka , Huopio Jukka , Kokki Hannu , Korhonen Sanni , Lehtonen Marko , Sjövall Sari , Kokki Merja 
Published: October 2023

Abstract
Methods
Fifty-six (56) patients scheduled for arthroplasty, received 7-day extended-release buprenorphine transdermal patches (5 µg/h) for five consecutive weeks, starting two weeks prior to the surgery. Simultaneous plasma and cerebrospinal fluid (CSF) samples were collected during spinal anesthesia.

Results
Median buprenorphine plasma and CSF concentrations at steady-state were 54 pg/mL (range 8.6 – 167 pg/mL) and 1.6 pg/mL (0.30 – 7.3 pg/mL), respectively. The median CSF/plasma -ratio was 3% (range 0.35 – 16%). Large between-subject variability was observed in the measured buprenorphine concentrations within the study population.
Wild Mountain reindeer Rangifer tarandus tarandus winter foraging: snow-free areas a key resource for feeding
Authors: Holtan Marijanne , Strand Olav , Kastdalen Leif , Bjerketvedt Dag K. , Odland Arvid , Pape Roland , Heggenes Jan 
Published: October 2023

AbstractIn a landscape with patchily distributed forage resources, an animal’s distribution may reflect the distribution of the resources if the population is forage-limited in time or space. This may be particularly explicit in climatically extreme and seasonally variable environments, notably alpine and polar environments during winter. Sustainable management considers the amount of available alpine ground lichen in winter as a predictor of carrying capacity for the last remaining populations of wild European Mountain reindeer Rangifer tarandus tarandus in alpine environments in South Norway. Ground lichen growth is constrained to elevated, wind-blown, snow-free ridges. However, wild Mountain reindeer also persist in areas providing little lichen resources. Our alternative functional hypothesis is that the critical resource is the amount of snow-free feeding areas during winter, which provide direct access to forage, likely to be energy-profitable regardless of the type of vegetation. We sampled animal-borne videos from wild Mountain reindeer during maximum accumulation of snow in late winter/spring, in three contrasting areas providing variable amounts of ground lichen and alternative vegetation resources. Direct observations of reindeer foraging via videos document an active selection and strong preference for feeding on snow-free patches, regardless of type of vegetation. Active ‘cratering’ in snow was not observed. In contrast, walking behaviours occurred much more frequently across snow-covered areas. Remote sensing data and analyses corroborated these observations. In the sustainable management of wild Mountain reindeer amounts of vegetated snow-free areas is an important functional predictor of winter carrying capacity.
Continuous glucose monitoring metrics following sub-Tenon’s injection of triamcinolone acetonide for diabetic macular edema
Authors: Sotani-Ogawa Rei , Kusuhara Sentaro , Hirota Yushi , Kim Kyung Woo , Matsumiya Wataru , Ogawa Wataru , Nakamura Makoto 
Published: October 2023

Abstract
Purpose
This pilot study aims to comprehensively evaluate the effects of sub-Tenon’s injection of triamcinolone acetonide (STTA) on glycemic control in patients with diabetic macular edema (DME) using professional continuous glucose monitoring (CGM).

Methods
This retrospective study analyzed changes in glycemic control in 20 patients with type 2 mellitus and DME following single STTA (20 mg/0.5 mL) using The FreeStyle Libre Pro system. Professional CGM provides core CGM metrics such as the percentage of time that glucose levels fall within a target range and include the time in range (TIR) (70–180 mg/dL), time above range (TAR) (> 180 mg/dL), and time below range (TBR) (< 70 mg/dL). Outcome measures were the changes in CGM metrics (TIR, TAR and TBR) and the percentage of patients in whom TAR increased by at least 10 percentage points (ppt) 4 days before to 4 days after STTA administration.

Results
The mean CGM metrics (TIR/TAR/TBR) were 75.5%/19.9%/4.4% 4 days before STTA and 73.7%/22.4%/3.5% 4 days after STTA; the metrics 4 days before and 4 days after STTA were not significantly different (P = 0.625 for TIR, P = 0.250 for TAR, and P = 0.375 for TBR). TAR increased by more than 10 ppt in four (20%) patients treated with sulfonylurea and/or insulin.

Conclusion
Although there were no significant changes in the CGM metrics, four patients developed CGM-measured hyperglycemia after STTA for DME.
Novel therapeutic perspectives in Noonan syndrome and RASopathies
Authors: Saint-Laurent Céline , Mazeyrie Laurène , Yart Armelle , Edouard Thomas 
Published: October 2023

AbstractNoonan syndrome belongs to the family of RASopathies, a group of multiple congenital anomaly disorders caused by pathogenic variants in genes encoding components or regulators of the RAS/mitogen-activated protein kinase (MAPK) signalling pathway. Collectively, all these pathogenic variants lead to increased RAS/MAPK activation. The better understanding of the molecular mechanisms underlying the different manifestations of NS and RASopathies has led to the identification of molecular targets for specific pharmacological interventions. Many specific agents (e.g. SHP2 and MEK inhibitors) have already been developed for the treatment of RAS/MAPK-driven malignancies. In addition, other molecules with the property of modulating RAS/MAPK activation are indicated in non-malignant diseases (e.g. C-type natriuretic peptide analogues in achondroplasia or statins in hypercholesterolemia). Conclusion: Drug repositioning of these molecules represents a challenging approach to treat or prevent medical complications associated with RASopathies.

What is Known:• Noonan syndrome and related disorders are caused by pathogenic variants in genes encoding components or regulators of the RAS/mitogen-activated protein kinase (MAPK) signalling pathway, resulting in increased activation of this pathway.• This group of disorders is now known as RASopathies and represents one of the largest groups of multiple congenital anomaly diseases known.

What is New:• The identification of pathophysiological mechanisms provides new insights into the development of specific therapeutic strategies, in particular treatment aimed at reducing RAS/MAPK hyperactivation.• Drug repositioning of specific agents already developed for the treatment of malignant (e.g. SHP2 and MEK inhibitors) or non-malignant diseases (e.g. C-type natriuretic peptide analogues in achondroplasia or statins in hypercholesterolaemia) represents a challenging approach to the treatment of RASopathies.
The inter-familiar issues of Greek parents facing childhood cancer
Authors: Nizamis Kleanthis , Kalliakmanis Vassilios , Koutsoupias Nikos , Polychronopoulou Sophia , Baka Margarita , Papakonstantinou Evgenia , Hatzipantelis Emmanouil 
Published: October 2023

AbstractCancer as a whole, but especially childhood cancer, creates a number of psychological, social, and family problems as well as practical and financial issues, which every parent is called upon to solve. This study focuses on childhood cancer and aims at a thorough analysis of the physical/organic, psychological, and social problems associated with the parents and relatives of a child with cancer. The special element in pediatric neoplasms is not only the vulnerable population target group, but also the set of secondary effects it has on the environment of the sick child. The research was conducted on a sample of 133 families of children with cancer, and the results were displayed after statistical processing and data analysis with R statistical software. The results of the study confirm with statistically significant data the effect of childhood cancer on the physical, mental, and social health and behavior of the parent. Thus, 53.8% of the respondents stated 5 and above on the 7-point Likert scale for fatigue issues, 55.6% for sleep disorders, 78.1% for stress, and 82.7% for fear. The key findings are characterized by high specificity as it is a unique study that reveals particular aspects of the Greek parent’s behavior, mind, and body during the period of their child’s illness. Conclusion: The effects of childhood illnesses, particularly when they are severe, such as neoplasms, present a looming threat, ushering in a multitude of adverse alterations in the daily lives of the affected child's family.

What is Known – What is New:• We know the effects that a childhood illness brings not only to the sick child, but also to the entire family circle. The new element in the present research is that these data reflect the situation in Greece, for which the research data in this area is quite limited. Our research is one of the few studies that demonstrate with statistical data the change in the psychosomatic health of the parent who has a child with cancer.
Evaluation of the safety profile and therapeutic efficacy of remdesivir in children with SARS-CoV-2 infection – a single-center, retrospective, cohort study
Authors: Kautsch Karolina , Wiśniowska Joanna , Friedman-Gruszczyńska Joanna , Buda Piotr 
Published: October 2023

AbstractDespite 3.5 years of the SARS-CoV-2 pandemic, we still lack effective drugs against COVID-19. The first and most widely used drug, remdesivir, has not yet been shown to be effective in adults. Even less is known about its effectiveness in children. Therefore, the aim of this retrospective study was to evaluate the safety and efficacy of remdesivir in pediatric patients with COVID-19 hospitalized in one medical center. The medical records of 328 children with COVID-19 were analyzed. Analysis was performed on the subgroups of children treated and not treated with remdesivir. Clinical data on general health, course of COVID-19 and treatment received were analyzed. Remdesivir was administered to 64 children, 16 to treat severe or critical illness and 48 because of the presence of risk factors to prevent progression to severe COVID-19. In children with severe COVID-19, remdesivir did not reduce the mortality rate. However, in patients with milder disease and risk factors, the drug significantly reduced the risk of progression to severe disease. Among adverse events, only mild aminotransferase elevations were observed in 4 patients, but none of these required discontinuation of treatment.Conclusions: Remdesivir is a safe treatment option for children with COVID-19. However, the efficacy of this therapy is still uncertain. It appears that in children with asymptomatic to moderate COVID-19 and risk factors for severe disease, remdesivir could be an effective method of prophylaxis. However, its efficacy in controlling severe disease is questionable and requires further study.

What is Known:• There are still no effective drugs to combat COVID-19, and the efficacy of the widely used remdesivir in adults is controversial.• All recommendations and guidelines on the use of remdesivir in the pediatric population are based mainly on clinical trials in adults.

What is New:• Remdesivir is a safe treatment for COVID-19 in the pediatric population.• In children with asymptomatic to moderate COVID-19 and risk factors for severe disease, remdesivir could be an effective drug to prevent disease progression. However, its efficacy in treating severe disease in children needs further exploration.
Surface fractures generated during the 2021 Reykjanes oblique rifting event (SW Iceland)
Authors: Bufféral Simon , Panza Elisabetta , Mannini Stefano , Hjartardóttir Ásta Rut , Nobile Adriano , Gies Nils , Óskarsson Birgir Vilhelm , Ruch Joël 
Published: October 2023

AbstractWe use a comprehensive dataset of field observations, high spatial resolution drone orthomosaics and digital terrain models (DTMs) to map, quantify and characterize the extensive ground fracturing related to the 2021 seismo-tectonic and volcanic activity in the Reykjanes Peninsula (Iceland). The dataset, spans an area of about 30 km$$^2$$

2

, where we map nearly 20 000 ground cracks with metric to decametric lengths and centimetric extensional offsets, revealing a dominant dextral shear, in agreement with published seismic data. Although striking in a direction similar to the volcanic systems in the Reykjanes Peninsula (N030–040), most fractures appear as en-échelon structures globally aligned along N-S-striking fault zones up to 3–4 km long. By examining the timing of ground fracturing through repeated field observations, seismic data and InSAR images, we associate a fracture zone with most earthquakes of M$$_\omega \ge 5.0$$

ω

≥
5.0

that occurred in the month preceding the March 2021 Fagradalsfjall eruption. We describe three preexisting N-S fault zones, with fault segments that were reactivated up to three times during the pre-eruptive seismic activity, while the magma intrusion did not trigger graben-related ground fractures typically observed during magmatic injections. Our depiction of a system dominated by strike-slip tectonic features helps in understanding the geometry and bookshelf-mode of tectonic activity along a diffuse and highly oblique extensional plate boundary. Evidence of transient fracturing is typically quickly lost because of erosion or lava flow burial, highlighting a potential under-representation of diffuse fracturing when studying old tectonic and volcanic systems.
Nonlinear GARCH-type models for ordinal time series
Authors: Jahn Malte , Weiß Christian H. 
Published: October 2023

AbstractDespite their relevance in various areas of application, only few stochastic models for ordinal time series are discussed in the literature. To allow for a flexible serial dependence structure, different ordinal GARCH-type models are proposed, which can handle nonlinear dependence as well as kinds of an intensified memory. The (logistic) ordinal GARCH model accounts for the natural order among the categories by relying on the conditional cumulative distributions. As an alternative, a conditionally multinomial model is developed which uses the softmax response function. The resulting softmax GARCH model incorporates the ordinal information by considering the past (expected) categories. It is shown that this latter model is easily combined with an artificial neural network response function. This introduces great flexibility into the resulting neural softmax GARCH model, which turns out to be beneficial in three real-world time series applications (air quality levels, fear states, cloud coverage).
Zinc oxide-ozonated olive oil as a new root canal filling material in primary molars: a clinical randomized controlled trial
Authors: EL-Desouky Shaimaa S. , Omer Shaimaa M. Mahfouz , Ghouraba Rehab F. , Latif Reham M. Ali Abdel , Kabbash Ibrahim A. , Hadwa Shimaa M. 
Published: October 2023

Abstract
Objectives
The complex root canal anatomy of primary teeth keeps it very tricky to attain appropriate cleansing by biomechanical instrumentation, so obtaining an obturating material with excellent antimicrobial properties is a challenge in current clinical pulpectomy practice. So, this study aimed to assess the clinical and radiographic performance of zinc oxide-ozonated olive oil as a primary root canal filling material.

Materials and methods
Ninety non-vital primary molars in children ranging from 4 to 8 years were allocated into three groups in which root canals were filled with zinc oxide-ozonated olive oil, zinc oxide-olive oil, and zinc oxide-eugenol (ZOE) according to each group after pulpectomy procedure. Clinical and radiographic evaluations were done at 3-, 6-, and 12-month follow-up periods. Statistical analysis was performed for the collected data.

Results
All study groups showed a significant improvement regarding clinical signs and symptoms during follow-up periods. Ozonated-olive oil group revealed a significant increase in furcation radiodensity and a decrease in periodontal ligament space at 3-, 6-, and 12-month follow-up intervals compared to other groups.

Conclusion
Zinc oxide-ozonated olive oil and zinc oxide-olive oil paste had shown good clinical and radiographic success for primary teeth pulpectomy.

Clinical relevance
The intricate torturous primary root canal anatomy, in addition to the child’s negative behavior, interferes with the complete debridement, so the long-lasting antibacterial effect of the primary root canal filling material aids in the pulpectomy success.
Hoarding titmice predominantly use Familiarity, and not Recollection, when remembering cache locations
Authors: Smulders Tom V. , Douglas Laura J. , Reza Daniel , Male Lucinda H. , Prysce Alexander , Alix Amélie , de Guzman Dodd Alexander , Read Jenny C. A. 
Published: October 2023

AbstractScatter-hoarding birds find their caches using spatial memory and have an enlarged hippocampus. Finding a cache site could be achieved using either Recollection (a discrete recalling of previously experienced information) or Familiarity (a feeling of “having encountered something before”). In humans, these two processes can be distinguished using receiver operating characteristic (ROC) curves. ROC curves for olfactory memory in rats have shown the hippocampus is involved in Recollection, but not Familiarity. We test the hypothesis that food-hoarding birds, having a larger hippocampus, primarily use Recollection to find their caches. We validate a novel method of constructing ROC curves in humans and apply this method to cache retrieval by coal tits (Periparus ater). Both humans and birds mainly use Familiarity in finding their caches, with lower contribution of Recollection. This contribution is not significantly different from chance in birds, but a small contribution cannot be ruled out. Memory performance decreases with increasing retention interval in birds. The ecology of food-hoarding Parids makes it plausible that they mainly use Familiarity in the memory for caches. The larger hippocampus could be related to associating cache contents and temporal context with cache locations, rather than Recollection of the spatial information itself.