bluuebunny/crossref_metadata_2025_split huggingface dataset:
Herman Daly’s Great Debates
Authors: Victor Peter A. 
Published: January 2024

Early in his long career, Herman Daly became disillusioned with the priority given to the pursuit of economic growth, especially by rich countries. Instead, he argued for an equitable, efficient, steady-state economy that could be sustained indefinitely on a finite planet. Accordingly, he made proposals relating to human well-being, measuring the economy, population, money and banking, globalization and trade, and for rethinking economics in general, learning from the life sciences and making economics consistent with the fundamental laws of physics. Daly was eager to discuss and debate his ideas with his economist peers, seeking reasons why he might be wrong and making the necessary corrections. This proved much harder to achieve than he anticipated, though he received numerous international awards for his work and was very influential, especially beyond the confines of mainstream economics. However, on several occasions Daly did engage in debates in the academic literature with some very distinguished economists. These included his mentor, Nicholas Georgescu-Roegen, on the longevity of a steady-state economy, recipients of the Nobel Memorial Prize in Economic Sciences Robert Solow and Joseph Stiglitz, on limits to growth, and Kenneth Arrow on overconsumption. With the passage of time, these and his other debates described in this commentary have become increasingly relevant because the excessive environmental pressures that so concerned Daly are greater than ever and rising. And although Daly’s frame of reference was typically national and global, lessons can also be learned from the debates that relate to sub-national regions and cities.
THE RELATIONSHIP BETWEEN INSULIN RESISTANCE, ADIPOKINES, LIPIDS AND LOW-GRADE INFLAMMATION IN PATIENTS WITH CARDIOVASCULAR DISEASE TREATED BY STATINS
Authors: Maksymets T.A , Sklyarova H.E. 
Published: January 2024

Background. Hypolipidemic and hypotensive therapy enables to improve prognosis and decrease the risk of cardiovascular pathologies, however, an intensive regimen of prescribing statins for patients with arterial hypertension (AH) combined with obesity can promote development of hyperinsulinemia and insulin resistance (IR), which are predictors of type 2 diabetes mellitus development.
Aim: To investigate the relationship between insulin resistance, adipokines, lipids and low-grade inflammation in patients with cardiovascular disease treated by statins.
Materials and methods: 81 patients with overweight and/or obesity and AH or combination of AH and CAD were involved. Patients’ age ranged from 35 to 79 years, among them there were 51 males and 30 females. ACE inhibitors and ARBs, diuretics were used for treatment of AH; atorvastatin was prescribed orally in the dose 20 mg or 40 mg per day permanently as hypolipidemic therapy.
Lipid spectrum, biochemical indices and glycated hemoglobin were determined according to common techniques on an analyzer “BioSystems” (Spain) using original kits of reagents. Concentration of insulin and hsCRP were determined on immunochemoluminescent analyzer “Immulite 2000” (Siemens, Germany). Insulin resistance index was calculated by the formula:
НОМA-IR=fasting insulin (mcIU/ml)*fasting glucose(mmol/L)/22.5
In НОМA-IR value > 2.77, patients were considered insulin resistant.
Leptin was measured using an ELISA kit DRG (USA). Adiponectin was quantified using the ELISA kit Mediagnost (Germany).
Results. It has been revealed in our investigation that body mass index, the level of systolic blood pressure, triglycerides, highly sensitive C-reactive protein and leptin were reliably higher in patients with IR, whereas adiponectin level was lower. These associations are confirmed by the results of studying correlations between IR index, adipokines, anthropometric and biochemical parameters. Thus, thorough evaluation of carbohydrate and adipokine profile in patients with cardiovascular pathology combined with obesity, who are subjected to hypolipidemic therapy, is an important factor in preventing type 2 diabetes mellitus.
Conclusion. Assessment of the risk of statin-induced diabetes mellitus is important for determining intensity of statin therapy, namely, presence of insulin resistance, levels of hsCRP and adipokines should be considered at the beginning and during treatment.
RISK FACTORS OF SEVERE PERITONITIS IN SURGICAL PATIENTS
Authors: Karol I.V. , Bilyaeva O.O. 
Published: January 2024

Background. Radical changes in clinical practice along with the introduction of new surgical interventions and the new concept of precision medicine justify the need to update the traditional scales for assessing the condition of patients with peritonitis.
Aim: to establish risk factors for the development of peritonitis in patients who were operated on for acute diseases of the abdominal cavity.
Material and methods. The study involved 139 patients who were operated on for acute diseases of the abdominal cavity, among whom 71 had acute appendicitis, 51 had acute cholecystitis, 10 had a perforated stomach or duodenal ulcer, others had perforation of a tumor or small intestine, a pinched hernia, cryptogenic peritonitis. Depending on the number of points on the modified APACHE II scale, patients were divided into two groups: 1st group - 1-3 points (63 people, 45.3%) and 2nd group - 4 or more points (76 people, 54.7%).Statistical processing of the research results was carried out using the EZR v.1.54 program (graphical user interface for R statistical software version 4.0.3, R Foundation for Statistical Computing, Vienna, Austria).
Results. Comparison of study groups showed that the more severe course of peritonitis was more common in men, had a greater prevalence, fibrous and purulent nature of the exudate, and was more often in the toxic stage. Patients of the second group were 6.5 years older (p=0.029), stayed longer in the hospital (by 2 days; p=0.002) and had a longer duration of surgery (by 25 minutes; p<0.001), a higher body temperature during hospitalization (by 0.4oC; p=0.008), which normalized one day later (p<0.001), as well as a lower ptrothrombin index (PTI) with higher values of international normalized ratio (INR) and prothrombin time (p<0.05), higher leukocytosis (p<0.001) and erythrocyte sedimentation rate (p=0.042) in comparison with the patients of the first group. Univariante regression analysis confirmed a positive effect on the risk of severe peritonitis of age, male gender, body temperature, pulse rate, EMN, and leukocytosis, and a negative effect of PTI value.
Conclusion. The following risk factors for severe peritonitis were identified: male sex and age, higher temperature at hospitalization and heart rate, higher PTI and INR, as well as higher leukocytosis.
THE PROBLEM OF PREDICTING THE OCCURRENCE OF ACUTE TOXIC EFFECTS, INCLUDING SKIN DISEASES, OF AGRICULTURAL WORKERS BEFORE APPLYING INSECTICIDES
Authors: Bardov H.P. , Vavrinevych О.P. О.P. 
Published: January 2024

Background. It has been proven that the using of pesticides can lead to the human health problems. Possible way of exposure: inhalation, transdermal or oral. The danger of using pesticides is manifested by acute or chronic effects. There is a possibility of skin damage by pesticides upon direct contact. Aim: hygienic assessment of the occurrence of acute toxic effects, including skin diseases, among agricultural workers before applying insecticides for agricultural crops protection. Materials and methods. Prediction of the occurrence of acute toxic effects was carried out by the coefficient of possible of inhalation poisoning (CPIP) and the coefficient of selective action of the pesticide in case of inhalation and dermal exposure (CSAing., CSAd.). Statistical analysis of the obtained results was carried out using the IBM SPSS Statistics Base v.22 license package and the MS Excel program (2000). Results. The occurrence of acute inhalation poisoning, as well as health problem caused by percutaneous exposure of pesticides, has low possibilities. The investigated groups of insecticides belong to low-hazard pesticides according to SSanRN 8.8.1.002-98. CSAing. indicators of analyzed pesticide formulations are higher then CSAd. values, except for RembekDuo (CSAd > CSAing, p>0.125). The obtained results showed that almost all analyzed insecticide formulations are more dangerous with dermal exposure. Conclusion. It was established that the occurrence of acute inhalation poisonings, as well as health problem caused by percutaneous exposure to pesticides has low possibilities according results of our own research and comparative analysis. The investigated groups of insecticides belong to low-hazard pesticides according to DSanPiN 8.8.1.002-98. The danger when using the analyzed insecticides is significantly higher with dermal exposure..
APPLICATION OF MINI-INVASIVE ECHO-CONTROLLED PERCUTANEOUS INTERVENTIONS IN PATIENTS WITH A COMPLICATED COURSE OF ACUTE PANCREATITIS
Authors: Kolosovych I.V. , Sydorenko R. A. , Hanol I.V. 
Published: January 2024

Background. Mini-invasive percutaneous echo-controlled puncture drainage interventions have certain limitations in case of location of local complications of acute pancreatitis of the right and central-right type due to the high risk of iatrogenic injuries as a result of possible uncontrolled advancement of the working part of the device.
Aim: to improve the results of surgical treatment of patients with acute pancreatitis through the introduction of improved techniques of miniinvasive percutaneous echo-controlled interventions in complicated course of the disease.
Materials and methods. The study was based on the results of examination of 187 patients with severe acute pancreatitis, who were divided into two groups: a comparison group – patients who used traditional methods of examination and treatment (n=92) and the main group – patients who used improved surgical tactics (n =95). To assess the effectiveness of surgical tactics in the studied groups, a comparative analysis of the applied methods, the frequency of postoperative complications, mortality, and the duration of hospitalization was carried out.
Results. The introduction of improved miniinvasive percutaneous echo-controlled surgical interventions expanded the possibilities of their use, including in the localization of infected local complications of the right and central-right type, and probably increased their effectiveness by 41.8% (p=0.02). A comparative analysis of the duration of inpatient treatment in the studied groups revealed a probable reduction in the terms of hospitalization of patients in the main group by 14.7 days (р=0.0008), of which in the intensive care unit – by 4.7 days (р<0.0001).
Conclusion. The use of improved methods of diagnosis and treatment in patients of the main group made it possible to reliably reduce the frequency of postoperative complications by 28% (p=0.003) and overall postoperative mortality by 27.7% (p=0.005).
Tatters & the Selvage Edge: A Palimpsestic Consideration of H.D.'s Poetics
Authors: Nguyen Hoa 
Published: January 2024

<div><a href="https://www.poetryfoundation.org/poets/h-d" target="_blank"><u>H.D.</u></a>’s poems extend memory, life experience, and archetypes inside of the metaphor of palimpsest. Her translations of <a href="https://www.poetryfoundation.org/poets/sappho" target="_blank"><u>Sappho</u></a> re-worked the remnants of Sappho’s lines, sometimes addressing the smallest lines in the original. The poem that results from her approach to Fragment 113—“Neither honey nor bee for me”—extend from it not as translation but as a trans-creation, both literalizing the loss of the original and creating a third possibility.</div>
<p>While H.D.’s poems made use of masks and speakers as/of characters from ancient Greece, she also translated Sappho—“re-workings” of her fragments from ancient Greek. </p>
<p>Like layers of wallpaper, parts solid and covered, parts in decay and tattered, the incompletion of the palimpsest become strategy to read, understand, and re-represent it to literalize the partial story, the story as and of fractures, and the multiplicity of experience.</p>
ESTRATÉGIAS DE ENDOMARKETING E SEUS BENEFÍCIOS PARA UMA ORGANIZAÇÃO DO SEGMENTO CONTÁBIL
Authors: Mota da Silva Beatriz , De Jesus Araújo Jeane , Rodrigues Santos Thayná , Bogdezevicius Carlos Rafael 
Published: January 2024

O endomarketing dispõe de diversas ferramentas que promovem uma eficaz comunicação entre os colaboradores, favorecendo a integração a fim de gerar vantagem competitiva no mercado. Sendo assim, foi desenvolvida uma pesquisa descritiva de natureza aplicada, com a problemática abordada de maneira qualitativa e quantitativa. No que se refere os procedimentos técnicos, foram realizados uma pesquisa bibliográfica e um levantamento (survey), aplicando-se um questionário com 10 perguntas para 48 colaboradores de um escritório de contabilidade. A questão central da pesquisa aborda de que maneira o endomarketing pode aumentar o nível de motivação dos colaboradores. Quanto aos resultados, é notório que todos os colaboradores devem ser considerados tão significativos quanto os clientes externos, uma vez que o cliente interno desempenha um papel central na representação da organização, podendo-se afirmar que as ferramentas do endomarketing são cruciais para alcançar os objetivos organizacionais e potencializar as funções dos colaboradores, de forma a gerar vantagem competitiva em um ambiente mercadológico cada vez mais agressivo.
Palavras-Chave: Endomarketing. Comunicação Interna. Contabilidade. Cliente Interno.

Abstract: Internal marketing has several tools that promote effective communication between employees, favoring integration in order to generate a competitive advantage in the market. Therefore, descriptive research of an applied nature was developed, with the problem addressed in a qualitative and quantitative way. With regard to technical procedures, a bibliographical research and a survey were carried out, applying a questionnaire with 10 questions to 48 employees of an accounting office. The central question of the research addresses how internal marketing can increase the level of motivation of employees. Regarding the results, it is clear that all employees must be considered as significant as external customers, since the internal customer plays a central role in representing the organization, and it can be said that internal marketing tools are crucial to achieving the objectives organizations and enhance the functions of employees, in order to generate competitive advantage in an increasingly aggressive market environment.
Keywords: Internal Marketing. Internal Communication. Accounting. Internal Costumer.
Centrifuge-Simulated Spaceflight After Aortic Valve Replacement and Atrial Septal Defect Repair
Authors: Fernandez William L. , Blue Rebecca S. , Harrison Michael F. , Powers William , Shah Ronak , Auñón-Chancellor Serena 
Published: January 2024

INTRODUCTION: Human access to space is expanding rapidly in the commercial environment, with various private companies offering commercial flights to spaceflight participants (SFPs). SFPs are more likely than career astronauts to have medical conditions novel to spaceflight and may not have undergone as rigorous a medical screening process as that used for career astronauts, representing new and unstudied risks in the spaceflight environment. We report participation of a subject with recent median sternotomy for aortic valve replacement and atrial septal defect closure in centrifuge-simulated dynamic phases of orbital and suborbital spaceflight.
CASE REPORT: A 40-yr-old man with a history of congenital bicuspid aortic valve and atrial septal defect with successful repair 8 mo prior participated in an ongoing human centrifuge research study. The subject had the opportunity to participate in up to five centrifuge runs in an 8-h period, with profiles simulating commercial spaceflight. Maximum exposures included +4.0 Gz, +4.5 Gx, 6.1 G resultant, and maximum onset rate < 0.5 Gz · s−1 and +1 Gx · s−1. Physiological data acquisition included hemodynamics, electrocardiogram, neurovestibular exams, and postrun questionnaires covering motion sickness, disorientation, and similar. The subject tolerated the physiological aspects of hypergravity well, noting progressive sternal pain with increasing +Gx, ultimately leading him to opt out of the final profile.
DISCUSSION: Postcardiothoracic surgery risks to SFPs are largely unknown, especially within 12 mo of a significant surgical procedure. This case provides an approach for risk stratification, preparticipation evaluation, and medical management of a postsurgical patient with significant cardiac history in spaceflight and analog environments.
Fernandez WL, Blue RS, Harrison MF, Powers W, Shah R, Auñón-Chancellor S. Centrifuge-simulated spaceflight after aortic valve replacement and atrial septal defect repair. Aerosp Med Hum Perform. 2024; 95(2):123–131.
Alcohol use and the pain system
Authors: Vigorito Michael , Chang Sulie L. 
Published: January 2024

The World Health Organization’s epidemiological data from 2016 revealed that while 57% of the global population aged 15 years or older had abstained from drinking alcohol in the previous year, more than half of the population in the Americas, Europe, and Western Pacific consumed alcohol. The spectrum of alcohol use behavior is broad: low-risk use (sensible and in moderation), at-risk use (e.g., binge drinking), harmful use (misuse) and dependence (alcoholism; addiction; alcohol use disorder). The at-risk use and misuse of alcohol is associated with the transition to dependence, as well as many damaging health outcomes and preventable causes of premature death. Recent conceptualizations of alcohol dependence posit that the subjective experience of pain may be a significant contributing factor in the transition across the spectrum of alcohol use behavior. This narrative review summarizes the effects of alcohol at all levels of the pain system. The pain system includes nociceptors as sensory indicators of potentially dangerous stimuli and tissue damage (nociception), spinal circuits mediating defensive reflexes, and most importantly, the supraspinal circuits mediating nocifensive behaviors and the perception of pain. Although the functional importance of pain is to protect from injury and further or future damage, chronic pain may emerge despite the recovery from, and absence of, biological damage (i.e., in the absence of nociception). Like other biological perceptual systems, pain is a construction contingent on sensory information and a history of individual experiences (i.e., learning and memory). Neuroadaptations and brain plasticity underlying learning and memory and other basic physiological functions can also result in pathological conditions such as chronic pain and addiction. Moreover, the negative affective/emotional aspect of pain perception provides embodied and motivational components that may play a substantial role in the transition from alcohol use to dependence.
Enhanced hemocompatibility and rapid magnetic anastomosis of electrospun small-diameter artificial vascular grafts
Authors: Liu Peng , Liu Xin , Yang Lifei , Qian Yerong , Lu Qiang , Shi Aihua , Wei Shasha , Zhang Xufeng , Lv Yi , Xiang Junxi 
Published: January 2024

Background: Small-diameter (&lt;6 mm) artificial vascular grafts (AVGs) are urgently required in vessel reconstructive surgery but constrained by suboptimal hemocompatibility and the complexity of anastomotic procedures. This study introduces coaxial electrospinning and magnetic anastomosis techniques to improve graft performance.Methods: Bilayer poly(lactide-co-caprolactone) (PLCL) grafts were fabricated by coaxial electrospinning to encapsulate heparin in the inner layer for anticoagulation. Magnetic rings were embedded at both ends of the nanofiber conduit to construct a magnetic anastomosis small-diameter AVG. Material properties were characterized by micromorphology, fourier transform infrared (FTIR) spectra, mechanical tests, in vitro heparin release and hemocompatibility. In vivo performance was evaluated in a rabbit model of inferior vena cava replacement.Results: Coaxial electrospinning produced PLCL/heparin grafts with sustained heparin release, lower platelet adhesion, prolonged clotting times, higher Young’s modulus and tensile strength versus PLCL grafts. Magnetic anastomosis was significantly faster than suturing (3.65 ± 0.83 vs. 20.32 ± 3.45 min, p &lt; 0.001) and with higher success rate (100% vs. 80%). Furthermore, magnetic AVG had higher short-term patency (2 days: 100% vs. 60%; 7 days: 40% vs. 0%) but similar long-term occlusion as sutured grafts.Conclusion: Coaxial electrospinning improved hemocompatibility and magnetic anastomosis enhanced implantability of small-diameter AVG. Short-term patency was excellent, but further optimization of anticoagulation is needed for long-term patency. This combinatorial approach holds promise for vascular graft engineering.
Comparison of metagenomic next-generation sequencing and blood culture for diagnosis of bloodstream infections
Authors: Yu Juan , Zhang Li , Gao Deyu , Wang Jie , Li Yi , Sun Ning 
Published: January 2024

ObjectivesThis study aimed to evaluate the clinical performance of plasma cell-free DNA (cfDNA) next-generation sequencing (NGS) for pathogen detection in patients with sepsis.MethodsA total of 43 pairs of blood and plasma samples form 33 blood culture-positive patients were used as testing samples in metagenomic NGS (mNGS) and NGS of 16S ribosomal RNA gene amplicons (16S rRNA NGS). The results of routine tests, including microbial culture, complete blood count, and biochemical tests, were collected from electronic medical records.ResultsUsing blood as an mNGS testing sample, the proportion of host DNA was 99.9%, with only three bacteria and no fungi detected. When using plasma in mNGS, the proportion of host DNA was approximately 97%, with 84 bacteria and two fungi detected. Notably, 16S rRNA NGS detected 15 and 16 bacteria in 43 pairs of blood and plasma samples, respectively. Blood culture detected 49 bacteria (23 gram-negative bacilli and 26 gram-positive cocci) and four fungi, with 14 bacteria considered contaminants by clinical microbiologists. For all blood cultures, plasma cfDNA mNGS detected 78.26% (19/23) gram-negative rods, 17% (2/12) gram-positive cocci, and no fungi. Compared to blood cultures, the sensitivity and specificity of plasma cfDNA mNGS for detecting bacteria and fungi were 62.07% and 57.14%, respectively.ConclusionCompared to blood, plasma is more suitable for the detection of bloodstream infections using mNGS and is less affected by host DNA. The positive detection rate of plasma cfDNA mNGS for bloodstream infections caused by gram-negative bacteria was higher than that caused by gram-positive cocci.