bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Key Influencers for Secondary Distribution of HIV Self-Testing Kits Among Chinese Men Who Have Sex With Men: Development of an Ensemble Machine Learning Approach
Authors: Jing Fengshi , Ye Yang , Zhou Yi , Ni Yuxin , Yan Xumeng , Lu Ying , Ong Jason , Tucker Joseph D , Wu Dan , Xiong Yuan , Xu Chen , He Xi , Huang Shanzi , Li Xiaofeng , Jiang Hongbo , Wang Cheng , Dai Wencan , Huang Liqun , Mei Wenhua , Cheng Weibin , Zhang Qingpeng , Tang Weiming 
Published: October 2023

Background
HIV self-testing (HIVST) has been rapidly scaled up and additional strategies further expand testing uptake. Secondary distribution involves people (defined as “indexes”) applying for multiple kits and subsequently sharing them with people (defined as “alters”) in their social networks. However, identifying key influencers is difficult.

Objective
This study aimed to develop an innovative ensemble machine learning approach to identify key influencers among Chinese men who have sex with men (MSM) for secondary distribution of HIVST kits.

Methods
We defined three types of key influencers: (1) key distributors who can distribute more kits, (2) key promoters who can contribute to finding first-time testing alters, and (3) key detectors who can help to find positive alters. Four machine learning models (logistic regression, support vector machine, decision tree, and random forest) were trained to identify key influencers. An ensemble learning algorithm was adopted to combine these 4 models. For comparison with our machine learning models, self-evaluated leadership scales were used as the human identification approach. Four metrics for performance evaluation, including accuracy, precision, recall, and F1-score, were used to evaluate the machine learning models and the human identification approach. Simulation experiments were carried out to validate our approach.

Results
We included 309 indexes (our sample size) who were eligible and applied for multiple test kits; they distributed these kits to 269 alters. We compared the performance of the machine learning classification and ensemble learning models with that of the human identification approach based on leadership self-evaluated scales in terms of the 2 nearest cutoffs. Our approach outperformed human identification (based on the cutoff of the self-reported scales), exceeding by an average accuracy of 11.0%, could distribute 18.2% (95% CI 9.9%-26.5%) more kits, and find 13.6% (95% CI 1.9%-25.3%) more first-time testing alters and 12.0% (95% CI –14.7% to 38.7%) more positive-testing alters. Our approach could also increase the simulated intervention’s efficiency by 17.7% (95% CI –3.5% to 38.8%) compared to that of human identification.

Conclusions
We built machine learning models to identify key influencers among Chinese MSM who were more likely to engage in secondary distribution of HIVST kits.

Trial Registration
Chinese Clinical Trial Registry (ChiCTR) ChiCTR1900025433; https://www.chictr.org.cn/showproj.html?proj=42001
A Digital Mental Health Support Program for Depression and Anxiety in Populations With Attention-Deficit/Hyperactivity Disorder: Feasibility and Usability Study
Authors: Tsirmpas Charalampos , Nikolakopoulou Maria , Kaplow Sharon , Andrikopoulos Dimitrios , Fatouros Panagiotis , Kontoangelos Konstantinos , Papageorgiou Charalabos 
Published: October 2023

Background
A total of 1 in 2 adults with attention-deficit/hyperactivity disorder (ADHD) struggles with major depressive or anxiety disorders. The co-occurrence of these disorders adds to the complexity of finding utility in as well as adherence to a treatment option. Digital therapeutic solutions may present a promising alternative treatment option that could mitigate these challenges and alleviate symptoms.

Objective
This study aims to investigate (1) the feasibility and acceptance of a digital mental health intervention, (2) participants’ engagement and retention levels, and (3) the potential efficacy with respect to anxiety and depression symptoms in a population with ADHD. Our main hypothesis was that a digital, data-driven, and personalized intervention for adults with coexisting ADHD and depressive or anxiety symptoms would show high engagement and adherence, which would be accompanied by a decrease in depressive and anxiety symptoms along with an increase in quality of life and life satisfaction levels.

Methods
This real-world data, single-arm study included 30 adult participants with ADHD symptomatology and coexisting depressive or anxiety symptoms who joined a 16-week digital, data-driven mental health support program. This intervention is based on a combination of evidence-based approaches such as cognitive behavioral therapy, mindfulness, and positive psychology techniques. The targeted symptomatology was evaluated using the Patient Health Questionnaire–9, Generalized Anxiety Disorder–7, and Barkley Adult ADHD Rating Scale–IV. Quality of life aspects were evaluated using the Satisfaction With Life Scale and the Life Satisfaction Questionnaire, and user feedback surveys were used to assess user experience and acceptability.

Results
The study retention rate was 97% (29/30), and high engagement levels were observed, as depicted by the 69 minutes spent on the app per week, 5 emotion logs per week, and 11.5 mental health actions per week. An average decrease of 46.2% (P<.001; r=0.89) in depressive symptoms and 46.4% (P<.001; r=0.86) in anxiety symptoms was observed, with clinically significant improvement for more than half (17/30, 57% and 18/30, 60%, respectively) of the participants. This was followed by an average increase of 23% (P<.001; r=0.78) and 20% (P=.003; r=0.8) in Satisfaction With Life Scale and Life Satisfaction Questionnaire scores, respectively. The overall participant satisfaction level was 4.3 out of 5.

Conclusions
The findings support the feasibility, acceptability, and value of the examined digital program for adults with ADHD symptomatology to address the coexisting depressive or anxiety symptoms. However, controlled trials with larger sample sizes and more diverse participant profiles are required to provide further evidence of clinical efficacy.
Implementación de un curso virtual de lectura crítica en estudiantes de medicina durante la pandemia COVID-19
Authors: Pierdant-Pérez Mauricio , Patiño-López María Isabel , Flores-García José Andrés , Jacques-García Fausto Abraham 
Published: October 2023

Introducción: En la carrera de médico cirujano de la facultad de medicina de la Universidad Autónoma de San Luis Potosí (MED-UASLP), se imparte un curso de lectura crítica (CLC) mediante la herramienta OPMER, esta es el acrónimo de Objetivo, Población, Metodología, Estadística, Resultados. El curso es presencial y por la pandemia de COVID-19, se impartió de manera virtual.
Objetivo: Determinar si el CLC impartido de manera virtual a alumnos del segundo semestre de MED-UASLP les permite evaluar la metodología de un artículo científico con resultados semejantes a los obtenidos por los profesores del curso.
Método: Se implementó el CLC a través de las plataformas de Moodle y Teams a 60 alumnos de segundo semestre de MED-UASLP, sin conocimiento previo de lectura crítica durante la materia de Informática Médica (mayo 2022). El curso constó de 10 horas divididas en 5 horas de clase virtual sincrónica Teams (Microsoft) y 5 horas de actividades relacionadas en Moodle. Al final, los alumnos revisaron la metodología de un artículo científico (en tiempo real) utilizando la herramienta OPMER, otorgando una calificación contrastada con la de los profesores del curso.
Resultados: Se obtuvo un promedio de 15.06 puntos con mínima de 10 y máxima de 18. El 30% (18) de los alumnos concordaron con la puntuación del grupo de profesores en 16 puntos, el 32% (19) de los alumnos puntuaron ±1 de la puntuación del grupo de profesores, y 18% (11) de los alumnos puntuaron ±2 de la puntuación del grupo de profesores, el 20% de los alumnos (12) se encontraron fuera de este rango.
Conclusiones: Mediante un CLC virtual se evidenció un resultado similar al del grupo de profesores al evaluar la metodología de un artículo, demostrando una probable utilidad para la enseñanza de habilidades de lectura crítica en esa modalidad.
Increasing the Throughput of Annotation Tasks Across Scales of Plant Phenotyping Experiments
Authors: Sheng Hudanyun , Gutierrez Jorge , Schuhl Haley , Murphy Katherine M. , Acosta-Gamboa Lucia , Gehan Malia A. , Fahlgren Noah 
Published: October 2023

PlantCV is an open-source open-development image analysis software
package for plant phenotyping written in Python that has been actively
developed since 2014. A new version of PlantCV was recently released.
Major goals of the version 4 release were to 1) simplify the process of
developing workflows by reducing the amount of coding needed; 2)
broadening the set of supported data types; and 3) introducing
interactive annotation tools that can be used directly in PlantCV
workflow notebooks. Here we highlight the use of point annotations that
can be used to quickly collect sets of points for parameterization of
functions such as regions of interest or the identification of landmark
points. Another application of point annotations this for image
annotation, which is a major bottleneck in plant phenomics. For example,
we have used point annotations to analyze microscopy images aimed at
measurement of quinoa salt bladders, the number and size of stomata, and
scoring of pollen germination. These tasks have traditionally been low
throughput and have required manual scoring, but our point annotation
tools can be used along with traditional segmentation methods to
semi-automatically detect and annotate images. The PlantCV point
annotation tools also allow users to correct semi-automated detection
results before classification (e.g., germinated vs non-germinated
pollen) and extraction of size & color traits per object. Once images
are annotated, results can be analyzed directly or potentially can be
used as labeled data in supervised learning methods.
Inventarisasi pengetahuan lokal hutan pesisir di Tatar Karang Tasikmalaya
Authors: CMS Samson , Bajari Atwar , Sugiana Dadang , Ilham Muhammad 
Published: October 2023

Local knowledge of an area doesn't exist without reason; it has an accompanying purpose and philosophy. There are certainly goals and philosophies behind the local knowledge that the Tatar Karang community of Tasikmalaya District holds. This research aims to understand the local knowledge of the coastal forests of the Tatar Karang community. This study uses a qualitative descriptive approach with methods of observation, in-depth interviews, and literature studies. It is organized based on the cultural inventory structure of Kemendikbud 2016 and the SECI Model. Informants in this research include traditional elders, customary stakeholders, village heads, cultural figures, religious figures, community leaders, youth leaders, and leaders of traditional families. The results of the study indicate that: 1) Historically, the coastal forest is a heritage of the customary system that existed long before 1861 and was implemented as a legal system in place at the time; 2) Conceptually, the coastal forest serves as a protective measure for residents from various natural disaster threats originating from the direction of the ocean; 3) Factually, the condition of the coastal forest is quite concerning due to land use conversion policies, resulting in much of its area being damaged; and 4) Strategies for preserving the coastal forest can be done through: 1) the SECI Model analysis, which includes socialization, externalization, combination, and internalization. This ensures that stakeholders, traditional internal parties, can supervise objectively; 2) maximizing the cultural approach through developing three traditions: hajat lembur, marak, and rarangkén huma; and 3) a popular method using new media. In conclusion, preserving this intangible cultural heritage is vital and, at the very least, should be done through inventory. Thus, this tacit knowledge heritage can be documented.
The organization of interaction the active objects of homogeneous digital structures
Authors: Стецюра Геннадий Георгиевич 
Published: October 2023

В статье расширены возможности взаимодействия активных устройств
(объектов) однородных цифровых систем. Система состоит из объектов,
которые расположены в пределах не более нескольких десятков метров и
организуют свое взаимодействие только собственными средствами. Объекты
могут быть стационарными и мобильными с произвольным и изменяемым во
времени взаимным расположением объектов. Однородность системы означает
отсутствие внешнего управления и равные возможности объектов
в организации их взаимодействия. Связи между объектами беспроводные
с использованием оптических или радиосигналов. Сигналы любого
объекта/̄источника непосредственно поступают ко всем объектам/̄приемникам.
Объект получает право передачи сигналов детерминировано в соответствии
со значением его приоритета, задаваемым динамически или статически.
Предложенные структура и способы взаимодействия позволяют объектам кроме
обычного для распределенных систем обмена сообщениями выполнять
распределенные групповые (ассоциативные) операции. В них объекты
одновременно устраняют группу конфликтов доступа к общему каналу обмена
данными, определяют состояние всех объектов системы и синхронно
выполняют совместные действия объектов, реагируя на непредвиденно
изменяющиеся внешние условия. Группа одновременно участвующих
в групповой операции объектов выбирается с указанием набора критериев,
которым должны обладать объекты. Однородность системы существенно
упрощает ее техническую реализацию, но включение в систему
неоднородности при усложнении системы ускоряет выполнение групповых
операций. Поэтому однородную систему предлагается использовать
в основном для связи между активными периферийными устройствами и связи
этих устройств с более сложными компьютерами кластера.
Evaluation of pharmacokinetic parameters of ubiquinol acetate, ubiquinone and ubiquinol in male Sprague-Dawley rats – A comparative study
Authors: Umesh Mohan Cheluru , Mukundan Geetha Kannoth , Seekallu Srinivas 
Published: October 2023

Objectives:
The objective of this study was to evaluate single-dose oral comparative pharmacokinetics studies of ubiquinol acetate (EnQ10), ubiquinone and ubiquinol in male Sprague-Dawley (SD) rats.

Materials and Methods:
Oral suspension formulations of ubiquinol acetate (EnQ10), ubiquinone, and ubiquinol at 300 mg/kg body weight (equivalent dose of ubiquinone) were prepared in 0.1% (v/v) Tween 80 and 15% (w/v) hydroxypropyl-α-cyclodextrin. Six animals per group for each compound were dosed with oral suspension formulations of EnQ10, ubiquinone, and ubiquinol. Blood samples were collected at time points of 1, 2, 4, 6, 8, 10, 24, 30, and 48 h and plasma samples were analysed using liquid chromatography with tandem mass spectrometry for the analyte’s ubiquinone and ubiquinol.

Results:
In EnQ10 dosed animals, the plasma mean concentration maximum, Cmax (347.83 ng/mL) of ubiquinol was found to be 2.52 times higher versus ubiquinone dosed animals (137.90 ng/mL). Furthermore, in EnQ10 dosed animals, the observed plasma exposure (AUClast) (4808.94 h*ng/mL) for ubiquinol was found to be 3.96 times higher versus. Ubiquinone dosed animals (1214.42 h*ng/mL). One-way ANOVA (Analysis of Variance) was performed for the Cmax and AUClast of ubiquinol. There was a significant increase (P < 0.05) in the Cmax and AUClast of ubiquinol in animals dosed with EnQ10 compared to the animals dosed with ubiquinone.

Conclusion:
The findings from this study indicated that ubiquinol acetate (EnQ10) showed better oral bioavailability compared to ubiquinone (CoQ10) when administered orally (300 mg/kg body weight equivalent dose of ubiquinone) in the male in male SD Rats.
ПОДХОДЫ К СОЗДАНИЮ СИСТЕМЫ ОЦЕНКИ УРОВНЯ УДОВЛЕТВОРЕННОСТИ ПАЦИЕНТОВ МЕДИЦИНСКОЙ ПОМОЩЬЮ, ОКАЗЫВАЕМОЙ В АМБУЛАТОРНЫХ УСЛОВИЯХ
Authors: Черкасов С. Н. , Мартиросов А. В. , Федяева А. В. 
Published: October 2023

Вопросы удовлетворенности медицинской помощью актуальны во всем мире, однако данное понятие субъективно. Существует зависимость между объективными критериями качества медицинской помощи и уровнем удовлетворенности пациента. Профессиональный подход к анализу качества медицинской помощи со стороны пациента невозможен, однако именно он является главным заказчиком медицинской помощи и определяет оправданность использования ресурсов с точки зрения общества. Требуется создать инструмент, который позволит полученные результаты удовлетворённости пациента использовать как критерий социальной эффективности системы здравоохранения. Кроме того, при таком подходе уровень удовлетворенности пациентов можно использовать как индикатор результативности или эффективности проводимых мероприятий по улучшению системы оказания медицинской помощи. Решить задачу создания такого инструмента можно с помощью метода стандартизации.Цель исследования: выполнить анализ зависимостей между детерминантами, влияющими на уровень удовлетворённости пациента медицинской помощью, оказываемой в амбулаторных условиях.Материалы и методы исследования. Было рассмотрено 9 детерминант, влияющих на оценку пациентом качества организации медицинской помощи, оказываемой в амбулаторных условиях: демографические характеристики (возраст, пол), социальные детерминанты (уровень образования, признание пациента ответственности за собственное здоровье, семейное положение пациента, степень комплаенса пациента), экономическая детерминанта (величина располагаемого дохода), жизненные приоритеты пациента («стандартность структуры жизненных приоритетов, значимость жизненного приоритета «Здоровье»).Результаты. Была сформирована симметричная корреляционная матрица размерностью 9×9 элементов, анализ которой показал, что сильной зависимости нет. Однако в процессе анализа были выявлены сочетания признаков, которые необходимо учитывать в ходе дальнейшего исследования (на последующих этапах).Заключение. По результатам анализа зависимости уровня удовлетворенности пациента полученной медицинской помощи от каждого фактора или группы связанных факторов были отобраны 11 связанных признаков. Ни одного независимого признака выявлено не было. Зависимости между изучаемыми параметрами сложные, и типичные методы вариационной статистики не позволяют получить однозначные результаты. Только использование специальных методов может позволить получить результат в виде пригодном для использования его в практических целях.
KARAKTERISTIK ORANGTUA BERDASARKAN PRESTASI HASIL BELAJAR SISWA DI SEKOLAH DASAR
Authors: Kurnia Asih , Puji Yanti Fauziah  
Published: October 2023

Penelitian ini bertujuan untuk mendeskripsikan karakteristik orang tua siswa berdasarkan perolehan hasil belajar siswa di sekolah dasar. Subjek penelitian ini adalah siswa kelas VI sekolah dasar yang berjumlah 23 siswa dengan siswa laki-laki sebanyak 11 dan siswa perempuan sebanyak 12 siswa. Analisis data diambil dari hasil nilai raport akhir tahun dengan membagi kelompok hasil belajar. Dari beberapa karakteristik orang tua yang dianalisis berdasarkan pengelompokkan hasil belajar ditemukan bahwa rata-rata siswa yang memiliki hasil belajar tinggi adalah mereka yang orang tuanya memiliki pendidikan SMA dengan pekerjaan sebagai wiraswasta dan rentang usia orang tua berkisar antara 41 – 55 tahun. Pada kategori hasil belajar rendah, pendidikan orang tua didominasi pada lulusan SMA dengan pekerjaan menjadi buruh dan rentang usia orangtua berkisar 46-55 tahun. Untuk kategori hasil belajar rendah lebih dominan pada latar belakang pendidikan orangtua pada jenjang SMP dan SMA dengan pekerjaan sebagai buruh dan karyawan, serta rentang usia orang tua yang masih produktif pada kisaran 41- 45 tahun. Dalam hal ini perlunya keterlibatan orang tua dalam proses belajar, dengan demikian orang tua hendaknya memberikan waktu luang kepada anak-anak untuk membersamai mereka dalam belajar dan membangun hubungan kedekatan orangtua dan anak sehingga terjalin motivasi yang kuat kepada anak.
Gênero e Educação: um olhar sob a ótica da pedagogia da autonomia
Authors: Castaman Ana Sara , Beltramin Chana Francini 
Published: October 2023

A discussão de gênero na educação é uma temática atual e ampla. Assim, este artigo tem por objetivo conhecer os conceitos de corpo, gênero e sexualidade, de modo a examinar sob a ótica da Pedagogia da Autonomia, possibilidades de ressignificar as concepções de gênero no processo educacional. Para tanto, por meio da técnica bibliográfica refletiu-se sobre: a) os conceitos de corpo, gênero e sexualidade; b) à Pedagogia da Autonomia, de Freire, enquanto uma possibilidade de ressignificar as concepções de gênero no processo educacional. Esta investigação configura-se como uma breve reflexão de cunho revisional teórico acerca do tema, que versou um debate no intuito de uma educação verdadeiramente democrática, com base na igualdade de gênero. Acredita-se que a concepção freiriana de pedagogia da autonomia é atemporal e pode ser acionada para enfrentar questões contemporâneas (corpo, gênero e sexualidade). Concluímos como imprescindível o respeito a autonomia dos alunos por parte da instituição escolar, considerando e compreendendo a multiplicidade de suas subjetividades, para fortalecer seus processos de autoconstrução. Por meio desses mecanismos autônomos de construção consciente de subjetividades será possível consolidar, na prática docente, o respeito à diversidade de gênero e às sexualidades diversas, rompendo com padrões e estereótipos nocivos e violentos.
Qualitative study legal protection of the implementation of anesthesiologists' duties in delegation of doctor authority: legal protection of anesthesiologists in carrying out professional duties
Authors: Listyaningrum Tri Hapsari , Sari Sri Mayang 
Published: October 2023

Anesthesiologists have the main duties in Anesthesia Structuring Care services, including pre-, intra, and post-anesthesia. Kepmenkes Number 251 of 2015 concerning National Guidelines for Anesthesiology and Intensive Therapy Medical Services and Minister of Health Regulation Number 31 of 2013 concerning the Implementation of Anesthesia Nurse Work are legal products that regulate the implementation of anesthesia services.Â The two Permenkes have regulated the authority to carry out anesthesia measures and are the responsibility of Anesthesiologists with their expertise and authority. The legal basis for delegation of authority for medical action is contained in the Law on Health Workers in Article 65 paragraph (1); in carrying out health services, health workers can receive a delegation of medical action from medical personnel. This study aims to determine the legal protection of anesthesiologists in carrying out delegation of authority for professional duties in hospitals. This research is qualitative research with the sociological juridical method and single case design. Purposive sampling with interviews with doctors and anesthesiologists related to the delegation of authority of as many as six people.Â The results of this study, anesthesiologists in carrying out their duties, have been protected by the existence of the hospital by law made by the medical committee with the Standard Operating Procedures and Details of Work Authority of doctors and anesthesiologists in hospitals. Research advice to maintain the proper exercise of the anesthesiologist's authority.