bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Electronic Health Records to Characterize Patients with Uncontrolled Hypertension in Two Large Health System Networks
Authors: Lu Yuan , Keeley Ellen C. , Barrette Eric , Cooper-DeHoff Rhonda M. , Dhruva Sanket S. , Gaffney Jenny , Gamble Ginger , Handke Bonnie , Huang Chenxi , Krumholz Harlan , Rowe Caitrin , Schulz Wade , Shaw Kathryn , Smith Myra , Woodard Jennifer , Young Patrick , Ervin Keondae , Ross Joseph 
Published: February 2024

Abstract
Background
Improving hypertension control is a public health priority. However, consistent identification of uncontrolled hypertension using computable definitions in electronic health records (EHR) across health systems remains uncertain.
Methods
In this retrospective cohort study, we applied two computable definitions to the EHR data to identify patients with controlled and uncontrolled hypertension and to evaluate differences in characteristics, treatment, and clinical outcomes between these patient populations. We included adult patients (≥ 18 years) with hypertension receiving ambulatory care within Yale-New Haven Health System (YNHHS; a large US health system) and OneFlorida Clinical Research Consortium (OneFlorida; a Clinical Research Network comprised of 16 health systems) between October 2015 and December 2018. We identified patients with controlled and uncontrolled hypertension based on either a single blood pressure (BP) measurement from a randomly selected visit or all BP measurements recorded between hypertension identification and the randomly selected visit).
Results
Overall, 253,207 and 182,827 adults at YNHHS and OneFlorida were identified as having hypertension. Of these patients, 83.1% at YNHHS and 76.8% at OneFlorida were identified using ICD-10-CM codes, whereas 16.9% and 23.2%, respectively, were identified using elevated BP measurements (≥ 140/90 mmHg). Uncontrolled hypertension was observed among 32.5% and 43.7% of patients at YNHHS and OneFlorida, respectively. Uncontrolled hypertension was disproportionately higher among Black patients when compared with White patients (38.9% versus 31.5% in YNHHS; p < 0.001; 49.7% versus 41.2% in OneFlorida; p < 0.001). Medication prescription for hypertension management was more common in patients with uncontrolled hypertension when compared with those with controlled hypertension (overall treatment rate: 39.3% versus 37.3% in YNHHS; p = 0.04; 42.2% versus 34.8% in OneFlorida; p < 0.001). Patients with controlled and uncontrolled hypertension had similar rates of short-term (at 3 and 6 months) and long-term (at 12 and 24 months) clinical outcomes. The two computable definitions generated consistent results.
Conclusions
Our findings illustrate the potential of leveraging EHR data, employing computable definitions, to conduct effective digital population surveillance in the realm of hypertension management.
Comparative Study of Stress Distribution in Tissue Surrounding Dental Implant Flexure: Continuum vs Full Body Analysis
Authors: Elshourbagy Salah 
Published: February 2024

Abstract
The use of dental implants has surged in popularity as an effective solution for individuals dealing with tooth loss. A successful dental implant must possess several essential qualities. It must be biocompatible to prevent any adverse reactions or rejection by the body. Furthermore, osseointegration, the fusion of the implant with the surrounding bone tissue, is crucial for stability and support. The implant should also demonstrate strength and durability to withstand biting and chewing forces without fracturing. Its long-lasting design is pivotal for ensuring durability over time. Additionally, the size and shape of the implant should be carefully selected to suit the patient's unique jawbone and surrounding tissues. To deepen our comprehension of dental implant behavior, we conducted a comparative study between a full-body diagram and the traditional continuum model for implant modeling. Our investigation revealed that incorporating a full-body diagram provides a more reliable and accurate simulation of the implant's response under various loading conditions. Moreover, the adaptability in size and shape of dental implants allows for the placement of different crown shapes and sizes, preserving the aesthetic appeal of the patient's teeth. By grasping the essential characteristics of successful dental implants and utilizing advanced modeling techniques, we can improve the outcomes of dental implant procedures.
The Symmetric Technique of Formant Transition Generation for Use in Speech Synthesis in the Arabic
Authors: Chegrani Lamari , Guerti Mhania , Boudraa Bachir 
Published: February 2024

Abstract
The objective of this work is to elaborate on a vocal communication aid system for blind individuals in the Arab world, which is also used as a system for learning Arabic for both individuals and nonnative speakers. This system is a result of the development of a speech synthesizer for the Arabic language, which is based on the concatenative synthesis method (end-to-end speech data collection (Eskenazi, Levow, Meng, Parent, & Suendermann, 2013)) of subsyllable sound units typically stored in digital wave format (Vaseghi, 2008), obtained using software called PRAAT (Gold, Morgan, & Ellis, 2011; Pleva, Juhár, & Thiessen, 2015)) from a natural language corpus (Chou, Tseng, & Lee, 2002). The treatments in this study took place in different phases (العماري, 2021). Text analysis techniques are responsible for converting incoming text into a linguistic representation that encodes information about how the input text should be pronounced (Shiga, Ni, Tachibana, & Okamoto, 2020). The method used to produce missing phonetic units in syllable counts (CVs) is to use mathematical symmetry from VCs, which results in the construction of a phonetic lexicon based on a reduced number of phonemes, which is 124, and improve the patterns resulting from inserting formula transitions into VCs generated from their counterpart (CVs) using this feature. Finally, after including the linear smoothing stage (Dutoit, 1994), speech outputs that resemble natural speech as much as possible without noise are obtained (Millstein, 2020); these outputs can be continuous and intelligible at different levels of language that can be employed in synthesizing intelligible speech for blind individuals in the Arab community, noting that this method is useful for all languages of the world in terms of producing the quality of speech.
Sharp corner singularity of the White-Metzner model
Authors: Jones Christian Alexander , Evans Jonathan David 
Published: February 2024

Abstract
The stress singularity is determined using matched asymptotics for complete flow of a White-Metzner (WM) fluid around a re-entrant corner. The model is considered in the absence of a solvent viscosity, with power-law forms for the relaxation time and polymer viscosity. In this form, the model shares the same stress singularity as the upper convected Maxwell (UCM) model, but its wall boundary layers may be thinner or thicker than those for UCM depending upon the relative difference in the power-law exponents. If the exponent for the relaxation time is greater than that for the polymer viscosity, the boundary layer is narrower, whilst it is thicker if the polymer viscosity exponent exceeds that of the relaxation time. When the exponents are the same, the WM boundary layer thickness is the same size as that for UCM. A self-similar solution is derived for the stress and velocity fields and matched to both upstream and downstream boundary layers. Restrictions on the sizes of the power-law exponents are also given for validity of this solution.
Mathematics Subject Classification (2010). 76A10 34E05/10/99.
An energy efficient way for quantitative magnetization switching
Authors: Hong Jeongmin , Li Xin , Bana Hanuman , Lin Jie , Zhang Shuai , Yi Bao , Chatterjee Jyotirmoy , Xiao Zhuyun , Mondal Sucheta , Tamura Nobumichi , Candler Rob N. , You Long , Bokor Jeffrey 
Published: February 2024

Abstract
When controlling ferroelectric (FE) and ferromagnetic (FM) properties together, this multiferroic system offers many opportunities for energy-efficient electronics such as memories, logic and other novel spintronic devices. Recent progress of electrically controlled spin devices blazes a trail to develop energy efficient devices by controlling magnetization switching. Here, we integrate spin orbit torque (SOT) devices in multiferroics and systematically study the angle dependency of SOT effects on a piezoelectric substrate to control localized in-plane strain using the electric field across the substrate. The controlled strain modulates the magnetization switching quantitatively through SOT in the multiferroic heterostructures. Besides, the strain shows distinguished modulation capability with the different orientations, which can immediately be used in logic arrays. The controllability of electric field on the magnetization switching behavior was revealed by harmonic Hall measurement, X-ray magnetic circular dichroism-photoemission electron microscopy (PEEM), X-ray diffraction, and magnetic force microscopy (MFM) as well as micromagnetic simulation. In virtue of electric-field-induced strain, the result finds the way for controlling SOT-induced magnetization switching with ultralow energy consumption, which will be applicable to the next generation spin-based logic devices.
Blue light irradiation inhibits the activation of cancer-associated macrophages in colon cancer
Authors: Yoshimoto Toshiaki , Nishi Masaaki , Okikawa Shohei , Yoshikawa Kozo , Tokunaga Takuya , Nakao Toshihiro , Takasu Chie , Kashihara Hideya , Wada Yuma , Noma Takayuki , Shimada Mitsuo 
Published: February 2024

Abstract
Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in cancer therapy. However, the effects of blue light irradiation on cells in the tumor microenvironment, including tumor-associated macrophages (TAMs), are unknown. Here, THP-1 cells were cultured in the conditioned medium (CM) of HCT-116 cells to prepare TAMs. TAMs were divided into LED-irradiated and control groups. Then, the effects of blue LED irradiation on TAM activation were examined. Expression levels of M2 macrophage markers CD163 and CD206 expression were significantly decreased in LED-irradiated TAMs compared with the control group. While control TAM-CM could induce HCT-116 cell migration, these effects were not observed in cells cultured in TAM-CM with LED irradiation. Vascular endothelial growth factor (VEGF) secretion was significantly suppressed in LED-exposed TAMs. PD-L1 expression was upregulated in HCT-116 cells cultured with TAM-CM but attenuated in cells cultured with LED-irradiated TAM-CM. In an in vivo model, protein expression levels of F4/80 and CD163, which are TAM markers, were reduced in the LED-exposed group. These results indicate that blue LED light may have an inhibitory effect on TAMs, as well as anti-tumor effects on colon cancer cells.
Efficacy of five Trichoderma species against anthracnose in pecan through mycoparasitism and antibiosis
Authors: Poletto Tales , Fantinel Vinícius Spolaor , Muniz Marlove Fátima Brião , Quevedo Alexsandra Cezimbra , Strahl Marisa Ana , Poletto Igor , stefenon valdir 
Published: February 2024

Abstract

Among the various diseases occurring in the pecan tree crop, anthracnose, caused by species of the genus Colletotrichum, stands out. Biocontrol using Trichoderma presents as a promising measure to be used in disease control because it has a broad spectrum of action on phytopathogens, enables the activation of the defense system, and the promotion of plant growth, contributes to environmental sustainability and food security. This work aimed to investigate the in vitro antagonistic action of Trichoderma species on Colletotrichum, the etiological agent of anthracnose in pecan. The dual-culture assay and the inhibition test by volatile metabolites were performed with five species of Trichoderma (T. harzianum, T. koningiopsis, T. asperellum, T. tomentosum, and T. virens). Mycelial growth was evaluated daily until the seventh day. In the dual-culture assay, all species showed antagonist potential, inhibiting the mycelial growth of the pathogens from the third day onward. Trichoderma virens and T. tomentosum showed greater antagonist potential and stood out in the volatile metabolites.
Robust design optimization using a non-intrusive second-order approximation of stochastic moments
Authors: Krüger Jan Christoph , Kriegesmann Benedikt 
Published: February 2024

Abstract
This paper presents a new formulation of the second-order fourth-moment method (sometimes referred to as second-order perturbation method or second-order method of moments). The method allows to efficiently predict the stochastic moments of a response function and is therefore often used within robust design optimization. The new approach allows a non-intrusive implementation at the same cost as existing, highly intrusive formulations. Therefore, the new approach can be applied to any objective function without significant implementation effort. It is based on a few finite difference steps into special directions an hence is dependent on the corresponding step sizes. An automatic step size procedure is supplied beside an detailed convergence analysis. The advantages of the new formulation are demonstrated by robust design optimizations of a 2D and a 3D example using the geometrically nonlinear finite element method.
Orbital characteristics and Oscillator strength in bulk, bilayer, and monolayer MoS2: A comparison study
Authors: Mansouri Masoume , Dezfuli Abdol-Mohammad Ghalambor , Salehi Hamdollah 
Published: February 2024

Abstract
In this article, the orbital characters and the oscillator strength of MoS2 in the bulk, monolayer, and bilayer structures have been studied and compared. The orbital characters are key parameters in determining the distribution and specifications of electrons in materials. The oscillator strength is also a quantity that represents the probability of electric dipole transitions. Here, the calculations of these parameters have been performed using the pseudopotential method based on density functional theory with generalized gradient approximation. For the bilayer structure, the calculations are based on the van der Waals corrected DFT. Using the results of the partial density of states obtained from the density functional theory, the orbital characters of all three structures are extracted. In addition, the oscillator strength has been derived from the matrix elements of the momentum operator using the first principles method. The results of orbital character and oscillator strength for bilayer and bulk are similar and completely different from those of the monolayer. Such similarities in orbital character and oscillator strength for the bulk and bilayer could be related to the fact that they belong to the point groups with the same symmetry characteristics. Accordingly, the difference in orbital character and oscillator strength of the monolayer MoS2 could be because the monolayer has a point group with different symmetry characteristics. Both bulk and bilayer structures belong to the D6h and D3d points groups with inversion center symmetry called centrosymmetric, and the monolayer belongs to the D3h points group without the inversion symmetry, named noncentrosymmetric.
A Hierarchical Bayesian Model to Monitor Pelagic Larvae in Response to Environmental Changes
Authors: Granata Alessia , Abbruzzo Antonino , Patti Bernardo , Cuttitta Angela , Torri Marco 
Published: February 2024

Abstract
European anchovies and round Sardinella play a crucial role, both ecological and commercial in the Mediterranean Sea.In this paper, we investigate the distribution of their larval stages by analyzing a dataset collected over time (1998 - 2016) and spaced along the area of the Strait of Sicily. Environmental factors are also integrated. We employ a hierarchical spatio-temporal Bayesian model and approximate the spatial field by a Gaussian Markov Random Field (GMRF) to reduce the computation effort using the Stochastic Partial Differential Equation (SPDE) method. Furthermore, the Integrated Nested Laplace Approximation (INLA) approximates the posterior distributions of model parameters. The results suggest a strong relationship between sea currents' directions and the distribution of larval European anchovies. For round sardinella, the analysis indicates increased sensitivity to warmer ocean conditions.
Effectiveness of insecticides in the control of Conotelus sp. (Coleoptera: Nitidulidae) in passionfruit
Authors: Cristino¹ Marcos Roberto Vitoria , Rondelli² Vando Miossi , Andrade³ Gilberto Santos , Souza Emanuel Fernando Maia , Cruz Paulo Vilela , Santos Lucas Silva , Piacentini Marcos Tadeu Simões , Maltezo Ketlen Faião Alves 
Published: February 2024

Abstract

Conotelus sp. (Coleoptera: Nitidulidae) is a substantial pest of passion fruit production in the Zona da Mata region of Rondônia, Brazil, making this agricultural activity unviable. This study evaluated the toxicity of registered and unregistered chemical insecticides for passion fruit cultivation against Conotelus sp. under laboratory conditions. Eight insecticides were evaluated at recommended field application concentrations. Passion fruit flowers sepals were immersed in insecticide solutions, and five larvae measuring 2 to 3 mm were placed on these sepals. Additionally, LC50 and LC90 values were determined for the insecticides fenpropathrin and chlorpyrifos. The results showed that chlorpyrifos, fenpropathrin, spinetoram, imidacloprid, chlorfenapyr, and thiamethoxam were effective in controlling Conotelus sp. larvae, demonstrating their potential for managing this insect pest. The LC50 values of chlorpyrifos and fenpropathrin for Conotelus sp. were 3.19 g a.i./100 L and 22.09 g a.i./100 L, respectively, showing the higher toxicity of chlorpyrifos. The estimated LC90 values for chlorpyrifos and fenpropathrin are 8.36 g a.i./100 L and 79.04 g a.i./100 L, respectively. These findings strengthen the scientific basis for selection and implementation of management measures to control Conotelus sp. in passion fruit plantations.
CONSORT adherence and risk of bias in Randomised Controlled Trials reports on deep caries management
Authors: Elagami Rokaia Ahmed , Reis Thais Marchezini , Hassan Mohamed Ahmed , Tedesco Tamara Kerber , Braga Mariana Minatel , Mendes Fausto Medeiros , Cenci Maximiliano Sérgio , Huysmans Marie-Charlotte , Raggio Daniela Prócida 
Published: February 2024

Abstract
Background
Recently, trials supported changes in deep caries management. However, reporting might lack details, affecting interpretation and implementation. Thus, we aimed to evaluate the adherence to the CONSORT statement and the risk of bias of Randomized Controlled Trials (RCTs) on deep caries management published in paediatric dental journals.
Methods
We searched PubMed for RCTs in six paediatric dental journals between 2010 to 2022, focusing on deep caries lesion management. Adherence to CONSORT guideline and risk of bias were assessed using a modified tool with 19 items scored from 0 to 2 (maximum 38 points) and assessed using Cochrane RoB 2. We performed descriptive and regression analyses (α = 5%).
Results
We analysed 127 RCTs. The mean (Standard Deviation) CONSORT adherence score was 21.1 (6.7). Notably, 96.1% of the studies received a score of 2 for the "intervention" item, whereas 83.5% scored 0 for "estimated effect size”. Risk of bias assessment revealed 40.1% with high risk, 59.1% with some concerns, and 0.8% with low risk. RCTs with a high risk of bias had lower CONSORT scores (p<0.001) than those with low or some concerns. RCTs published in journals without the endorsement of the CONSORT statement show lower scores than those in journals endorsing the CONSORT statement. Older RCTs (6-10 years old and more than 10 years old) show significantly lower CONSORT statement compliance than trials published recently within 5 years.
Conclusion
Among investigated RCTs, adherence to CONSORT is relatively low. Moreover, a lower adherence to CONSORT was associated with a higher risk of bias.
Registration: This study protocol was prospectively registered on Open Science Framework - DOI (10.17605/OSF.IO/V6SYZ).
Advances in the use of herbal drugs via the use of nanotechnology for impaired wound healing in diabetic patients with anti-inflammatory activity
Authors: Chaudhari Kedar N. , Lohar Neha A. , Girase Manoj V. 
Published: February 2024

Abstract
Diabetes mellitus (DM) is a chronic condition characterized by elevated blood glucose levels, leading to nerve and blood vessel damage, organ failure, and impaired wound healing. Wound healing in diabetic patients is further complicated by reduced cytokine responses and delayed healing processes, which can lead to severe complications such as sepsis and gangrene if left untreated. In this study, we explored the potential of acemannan, an herbal extract from aloe gel incorporated into niosomes, for wound healing. Acemannan exhibits antihyperglycemic, antiseptic, and anti-inflammatory properties with discrete delivery mechanisms and minimal side effects. The aim of this study was to develop herbal-loaded niosomes for wound healing. Niosomes, self-assemblies of nonionic surfactants with or without cholesterol, offer versatile delivery systems for both hydrophilic and hydrophobic substances. The formulation consisted of Span 60, cholesterol, chloroform, methanol, buffer, and spray-dried aloe vera powder, prepared using the Thin Hydration methodThe resulting herbal niosomes were evaluated for entrapment efficiency, particle size, and zeta potential. A batch with a 2:2 ratio of Span 60 and cholesterol exhibited favorable characteristics with a particle size of 144.1 nm and a zeta potential of -17.1 mV. In conclusion, the developed herbal-loaded niosome formulation shows promise for wound healing, offering a potentially safer and more effective alternative to traditional antibiotic treatments for diabetic wounds.
Integrated Assessment of Kirala Kele Wetland Health: Bridging the Gap between Water Quality Parameters and Biotic Components
Authors: Aththanayake A. M. N. S. , Nikawela N. D. L. , Bellanthudawa B. K. A. , Wijetunga S. 
Published: February 2024

Abstract
The present study was carried out to assess the health of the Kirala Kele Wetland, Sri Lanka, by coupling water quality indices and bioindicators. A total of 12 sampling sites were selected to represent different land-use patterns of the Kirala Kele Wetland using purposive sampling technique, and sampling was conducted from March 2021 to May 2021, on a monthly basis. Triplicated samples (n = 3) were obtained for each sampling event at each sampling site. Aquatic macroinvertebrates were collected from each site to determine the biological water quality using the Biological Monitoring Working Party (BMWP) score. Weighted Arithmetic Water Quality Index (WAWQI) was calculated to understand the physicochemical parameters of water, and the mean values of physicochemical water quality parameters were compared with the Sri Lankan water quality standards. According to the WAWQI for the different sampling sites, water is not suitable for drinking without treatment. The resulted BMWP score (BMWP = 61) shows that the water quality is acceptable (clean but slightly impacted) for biotic components of the wetland in accordance with the aquatic macroinvertebrates present. Spatial variation in water quality parameters and the aquatic macroinvertebrates were taken into account, and the temporal variation in water quality parameters within the 3 months from March to May was considered.