bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beta thalassemia: Looking to the future, addressing unmet needs and challenges
Authors: Angastiniotis Michael 
Published: January 2024

AbstractThalassemia management has reached new milestones, with new therapies promising the dawning of a new era. However, conventional and new approaches require accessibility, affordability, acceptability/adherence by patients, and medical expertise from healthcare providers. Current treatments still do not offer the expected duration and quality of life, and inequalities in patient care are almost a universal phenomenon. To understand the requirements to achieve improved care, including the adoption of new therapies, for the maximum number of the global patient population, it is necessary to recognize the weaknesses that are experienced in the present so that future corrective action can be taken. Deficits in service provision are due to poor political and financial support, lack of prioritization during resource rationing, and absence of epidemiological information for policy making. These system weaknesses require improved resource management and would benefit from patient support organizations, improved psychosocial support and patient welfare, and an increase in professional expertise through educational programs. Medical products and technology must also be made affordable and widely available, and the curative treatments and cheaper approaches to technology must be recognized as resource saving. Improvements in the access to innovative and quality care, and even a cure, require concerted actions by all stakeholders, including physicians and the patient community.
Three‐dimensional analysis of mandibular morphology asymmetry and temporomandibular joint position in patients with unilateral Brodie bite
Authors: Wu J. , Jia W. , Su X. , Zhang K. , Huang Y. , Lei Y. 
Published: January 2024

AbstractObjectivePrevious studies have shown unilateral posterior crossbite is associated with mandibular asymmetry in morphology and position. However, it remains unclear whether unilateral Brodie bite plays a similar role in mandibular development. Therefore, this study aims to investigate the morphological and positional symmetry of mandibles in patients with unilateral Brodie bite by three‐dimensional anaylsis.MethodsFourteen patients with unilateral Brodie bite (mean age 18.43 ± 4.24 years) and fourteen sex‐ and age‐matched patients with normal occlusion (mean age 18.07 ± 5.48 years) underwent cone‐beam computed tomography (CBCT) scans. 3D surface mesh models of their mandibles were established using Mimics Research 19.0. The surface matching percentage was compared between the original and mirrored mandible by Geomagic Control X software. Furthermore, the dimension and position of the temporomandibular joint (TMJ) were determined for both groups using InVivoDental 5.0.ResultsFor surface‐to‐surface deviation analysis, the percentage of mismatch in patients with unilateral Brodie bite was significantly higher than the control group at ±0.50 mm, ±0.75 mm, and ±1.00 mm tolerance (P < .001). In patients with unilateral Brodie syndrome, the condyles on the scissors‐bite side showed a significantly more anterior position (P = .03), greater medial inclination (P < .01), and larger posterior TMJ space (P = .01) than the non‐scissors‐bite side.ConclusionPatients with unilateral Brodie bite exhibit a more asymmetrical mandibular morphology, with a greater anterior condylar position and posterior joint space on the scissors‐bite side, indicating that early diagnosis and treatment may be necessary for patients with unilateral Brodie bite.
Plant microphenotype: from innovative imaging to computational analysis
Authors: Zhang Ying , Gu Shenghao , Du Jianjun , Huang Guanmin , Shi Jiawei , Lu Xianju , Wang Jinglu , Yang Wanneng , Guo Xinyu , Zhao Chunjiang 
Published: January 2024

SummaryThe microphenotype plays a key role in bridging the gap between the genotype and the complex macro phenotype. In this article, we review the advances in data acquisition and the intelligent analysis of plant microphenotyping and present applications of microphenotyping in plant science over the past two decades. We then point out several challenges in this field and suggest that cross‐scale image acquisition strategies, powerful artificial intelligence algorithms, advanced genetic analysis, and computational phenotyping need to be established and performed to better understand interactions among genotype, environment, and management. Microphenotyping has entered the era of Microphenotyping 3.0 and will largely advance functional genomics and plant science.
An in vitro study on the effects of photobiomodulation by diode lasers (red, infrared, and red–infrared combination) on periodontal ligament mesenchymal stem cells treated with bisphosphonates
Authors: Safari Amir Hossein , Sadat Mansouri Saeed , Iranpour Babak , Hodjat Mahshid , Hakimiha Neda 
Published: January 2024

AbstractThis study evaluated the effect of photobiomodulation therapy (PBMT) using 660 and 808 nm diode lasers (individual and in combination) on periodontal ligament mesenchymal stem cells (PDLSCs) in the presence of zoledronic acid (ZA). PDLSCs were cultured for 48 h in DMEM complete medium containing 5 μM ZA. PBMT was done three times with a 24‐h interval in groups 1 (660 nm, 5 J/cm2), 2 (880 nm, 3 J/cm2), and 3 (660 + 808 nm) either in normal or ZA‐treated culture medium. Control groups did not receive PBMT. Twenty‐four hours post‐irradiation, cell proliferation and expression of RANKL and OPG were assessed using MTT and real‐time PCR tests, respectively. The results showed a significant decrease in cell viability in ZA‐treated cells (p < 0.001). Additionally, ZA induced the expression of OPG (p = 0.03) while reducing RANKL (p < 0.001). Cell proliferation was significantly increased in 808 and 660 + 808 nm groups. Moreover, all PBMT groups could significantly increase and decrease the RANKL and OPG, respectively, in the presence of ZA (all p < 0.001). A combination of 660 + 808 nm showed the highest effects on both genes. In conclusion, it seems that PBMT can modulate the effects of ZA by inducing PDLSC proliferation and increasing RANKL‐to‐OPG gene expression ratio.
Disparities and social determinants of periodontal diseases
Authors: Albandar Jasim M. 
Published: January 2024

AbstractPeriodontal diseases are highly prevalent in populations worldwide and are a major global public health problem, with major negative impacts on individuals and communities. This study investigates evidence of disparities in periodontal diseases by age groups, gender, and socioeconomic factors. There is ample evidence that these diseases disproportionally affect poorer and marginalized groups and are closely associated with certain demographics and socioeconomic status. Disparities in periodontal health are associated with social inequalities, which in turn are caused by old age, gender inequality, income and education gaps, access to health care, social class, and other factors. In health care, these factors may result in some individuals receiving better and more professional care compared to others. This study also reviews the potential causes of these disparities and the means to bridge the gap in disease prevalence. Identifying and implementing effective strategies to eliminate inequities among minorities and marginalized groups in oral health status and dental care should be prioritized in populations globally.
Ageism scale for dental students (ASDS): A focus group review of content validity
Authors: Elliott Kendall , Dukes Kimberly C. , Barlow Patrick B. , Kossioni Anastassia , Marchini Leonardo 
Published: January 2024

AbstractPurpose/aimImprove content validity of the Ageism Scale for Dental Students (ASDS) and identify barriers to using the scale.MethodsThematic analysis of transcripts of three purposively sampled focus groups of 1) geriatric dentistry specialists, 2) older adult dental patients, and 3) dental students.ResultsTwenty‐five participants engaged in focus groups. No new concepts to define ageism were identified. Experts found the scale acceptable and appropriate, yet they raised specific potential revisions to scale questions. Commonly reported themes already addressed by ASDS included the importance of tailoring decision‐making to patient preference and not making assumptions about older adults’ capacity or preferences for dental care. Barriers to identifying ageism or using the scale included experiential differences in interpreting scale items, cultural differences in attitudes towards older adults, and potential overlap with social determinants of health. Secondary findings include recommendations for older‐adult focused training for dental students to provide positive, concrete guidance on caring for older adults.ConclusionThere are opportunities to refine the Ageism Scale for Dental Students and to allow tailoring of the scale for specific national or cultural contexts.
On the sheafyness property of spectra of Banach rings
Authors: Bambozzi Federico , Kremnizer Kobi 
Published: January 2024

AbstractLet be a non‐Archimedean Banach ring, satisfying some mild technical hypothesis that we will specify later on. We prove that it is possible to associate to a homotopical Huber spectrum via the introduction of the notion of derived rational localization. The spectrum so obtained is endowed with a derived structural sheaf of simplicial Banach algebras for which the derived C̆ech–Tate complex is strictly exact. Under some hypothesis, we can prove that there is a canonical morphism of underlying topological spaces that is a homeomorphism in some well‐known examples of non‐sheafy Banach rings, where is the usual Huber spectrum of . This permits the use of the tools from derived geometry to understand the geometry of in cases when the classical structure sheaf is not a sheaf.
Bott‐integrable Reeb flows on 3‐manifolds
Authors: Geiges Hansjörg , Hedicke Jakob , Sağlam Murat 
Published: January 2024

AbstractThis paper is devoted to studying a notion of Bott integrability for Reeb flows on contact 3‐manifolds. We show, in analogy with work of Fomenko–Zieschang on Hamiltonian flows in dimension 4, that Bott‐integrable Reeb flows exist precisely on graph manifolds. We also show that all ‐invariant contact structures on Seifert manifolds, as well as all contact structures on the 3‐sphere, on the 3‐torus and on , admit Bott‐integrable Reeb flows. Along the way, we establish some general Liouville‐type theorems for Bott‐integrable Reeb flows, and a number of topological constructions (connected sum, open books, Dehn surgery) that may be expected to have wider applications.
Modeling Running via Optimal Control for Shoe Design
Authors: Fay Sarah C. , Hosoi A. E. 
Published: January 2024

Abstract
Shoe manufacturing technology is advancing faster than new shoe designs can viably be evaluated in human subject trials. To aid in the design process, this paper presents a model for estimating how new shoe properties will affect runner performance. This model assumes runners choose their gaits to optimize an intrinsic, unknown objective function. To learn this objective function, a simple two-dimensional mechanical model of runners was used to predict their gaits under different objectives, and the resulting gaits were compared to data from real running trials. The most realistic model gaits, i.e., the ones that best matched the data, were obtained when the model runners minimized the impulse they experience from the ground as well as the mechanical work done by their leg muscles. Using this objective function, the gait and thus performance of running under different shoe conditions can be predicted. The simple model is sufficiently sensitive to predict the difference in performance of shoes with disruptive designs but cannot distinguish between existing shoes whose properties are fairly similar. This model therefore is a viable tool for coarse-grain exploration of the design space and identifying promising behaviors of truly novel shoe materials and designs.
Material Properties of Fiber Bundles of the Superficial Medial Collateral Ligament of the Knee Joint
Authors: Chen Wentao , Zhou Qing , Tang Jisi 
Published: January 2024

Abstract
The superficial medial collateral ligament (sMCL) of the human knee joint has functionally separate anterior and posterior fiber bundles. The two bundles are alternatively loaded as the knee flexion angle changes during walking. To date, the two bundles are usually not distinguished in knee ligament simulations because there has been little information about their material properties. In this study, we conducted quasi-static tensile tests on the sMCL of matured porcine stifle joints and obtained the material properties of the anterior bundle (AB), posterior bundle (PB), and whole ligament (WL). AB and PB have similar failure stress but different threshold strain, modulus, and failure strain. As a result, we recommend assigning different material properties (i.e., modulus and failure strain) to the two fiber bundles to realize biofidelic ligament responses in human body models. However, it is often inconvenient to perform tensile tests on AB and PB. Hence, we proposed a microstructural model-based approach to predict the material properties of AB and PB from the test results of WL. Such obtained modulus values of AB and PB had an error of 2% and 0.3%, respectively, compared with those measured from the tests. This approach can reduce the experimental cost for acquiring the needed mechanical property data for simulations.
Design and implementation of a seismic Newtonian noise cancellation system for the Virgo gravitational-wave detector
Authors: Koley Soumen , Harms Jan , Allocca Annalisa , Badaracco Francesca , Bertolini Alessandro , Bulik Tomasz , Calloni Enrico , Cieslar Marek , De Rosa Rosario , Errico Luciano , Esposito Marina , Fiori Irene , Hild Stefan , Idzkowski Bartosz , Masserot Alain , Mours Benoît , Paoletti Federico , Paoli Andrea , Pietrzak Mateusz , Rei Luca , Rolland Loïc , Singha Ayatri , Suchenek Mariusz , Suchinski Maciej , Tringali Maria Concetta , Ruggi Paolo 
Published: January 2024

AbstractTerrestrial gravity perturbations caused by seismic fields produce the so-called Newtonian noise in gravitational-wave detectors, which is predicted to limit their sensitivity in the upcoming observing runs. In the past, this noise was seen as an infrastructural limitation, i.e., something that cannot be overcome without major investments to improve a detector’s infrastructure. However, it is possible to have at least an indirect estimate of this noise by using the data from a large number of seismometers deployed around a detector’s suspended test masses. The noise estimate can be subtracted from the gravitational-wave data, a process called Newtonian noise cancellation (NNC). In this article, we present the design and implementation of the first NNC system at the Virgo detector as part of its AdV+ upgrade. It uses data from 110 vertical geophones deployed inside the Virgo buildings in optimized array configurations. We use a separate tiltmeter channel to test the pipeline in a proof-of-principle. The system has been running with good performance over months.
Limited Access to Aortic Valve Procedures in Socioeconomically Disadvantaged Areas
Authors: David Guy , Bergman Alon , Gunnarsson Candace , Ryan Michael , Chikermane Soumya , Thompson Christin , Clancy Seth 
Published: January 2024

Background
To explore how differences in local socioeconomic deprivation impact access to aortic valve procedures and the treatment of aortic valve disease, in comparison to other open and minimally invasive surgical procedures.

Methods and Results

Procedure volume data were obtained from the Healthcare Cost and Utilization Project from 18 states from 2016 to 2019 and merged with area deprivation index data, an index of zip code‐level socioeconomic distress. We estimate the relationship between local deprivation ranking and differences in volumes of aortic valve replacement, which include transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR), versus coronary artery bypass graft surgery and laparoscopic colectomy (LC). All regressions control for state and year fixed effects and an array of zip code‐level characteristics. TAVR procedures have increased over time across all zip codes. The rate of increase is negatively correlated with deprivation ranking, regardless of the higher share of hospitalizations per population in high deprivation areas. Distributional analysis further supports these findings, showing that lower area deprivation index areas account for a disproportionately large share of SAVR, TAVR, and LC procedures in our sample relative to their share of all hospitalizations in our sample. By comparison, the cumulative distribution of coronary artery bypass graft procedures was nearly identical to that of total hospitalizations, suggesting that this procedure is equitably distributed. Regressions show high area deprivation index areas have lower prevalence of SAVR (
β
=−15.1%, [95% CI, −26.8 to −3.5]), TAVR (
β
=−9.1%, [95% CI, −18.0 to −0.2]), and LC (
β
=−19.9%, [95% CI, −35.4 to −4.4]), with no statistical difference in the prevalence of coronary artery bypass graft (
β
=−2.5%, [95% CI, −12.7 to 7.6]), a widespread and commonly performed procedure. In the population aged ≥80 years, results show high area deprivation index areas have a lower prevalence of TAVR (
β
=−11.9%, [95% CI, −18.7 to −5.2]) but not SAVR (
β
=−0.8%, [95% CI, 8.1 to 6.3]), LC (
β
=−3.5%, [95% CI, −13.4 to −6.4]), or coronary artery bypass graft (
β
=5.2%, [95% CI, −1.1 to 1.1]).

Conclusions
People living in high deprivation areas have less access to life‐saving technologies, such as SAVR, and even moreso to device‐intensive minimally invasive procedures such as TAVR and LC.
Pigs and Pathogens: “Swine Flu” as a Boundary Object for Animal Rights and Farming Discourses
Authors: Couture Abigail A. 
Published: January 2024

Abstract
This paper considers the ways in which discourse around the 2009 Swine Flu outbreak reflects differences in framing and symbolic boundary negotiation amongst animal rights organizations, small scale farming advocates and meat industry representatives. Frame analysis shows how “Swine Flu” is treated as a “boundary object” to negotiate its significance and meaning for human and non-animal health writ large. The ambiguity of the virus’ origins, who was responsible, and who should care allowed Swine Flu to emerge as a boundary object for stakeholders to negotiate within public health discourse. Thematic analysis identified six separate frames, revealing patterns of meaning-making by animal rights organizations (AROs), farm-to-table groups, and meat industry networks. Frame use illustrates how Swine Flu was situated by competing stakeholders to reinforce a network of boundaries. Future directions consider the applicability of frames to understand boundary processes during COVID-19.
Evaluation of antibacterial activities of hemolymph and methanol extracts from black soldier fly (Hermetia illucens)
Authors: Luo Y.H. , Ye B.P. , Gao S.Q. , Tang G.J. , Li D.P. , Huang Y.H. , Huang Z.Z. , Yang X. , Naman A.M. , Qian Y.X. , Tan Z. , Zeng X.Y. , Wang B. 
Published: January 2024

Abstract
Black soldier fly (BSF) has been recently recognized as a promising source of antibacterial substances such as antimicrobial peptides (AMPs) and medium-chain fatty acids (MCFAs). This study aimed to isolate and identify the antibacterial activities of hemolymph and methanol extracts from BSF. The BSF larvae hemolymph increased the growth of bacteria which is likely due to its nutritional effects. However, the bacteria (Listeria monocytogenes, Staphylococcus aureus, Salmonella typhimurium, and Escherichia coli) treated with the hemolymph from bacteria inoculated BSF larvae showed slower growth when compared with the bacteria treated with the unchallenged hemolymph, and such a difference was dramatically eliminated by proteinase K and proteins/peptides between 3-10 kDa were the most active substances that affected the growth of bacteria. However, the antibacterial activity of BSF hemolymph was not strong enough to develop a visible inhibition zone in the Zone of Inhibition test against any of the four bacteria strains above. Methanol extracts from III instar BSF larvae, V instar BSF larvae, and BSF prepupae showed strong antibacterial activities in the Zone of Inhibition test against the four bacteria strains, and it is resistant to proteinase K treatment. The antibacterial activity and the percentage of fatty acids in the methanol extracts increased with age. Heating at 130 °C for 60 min significantly improved the antibacterial ability of methanol extracts against Staphylococcus aureus without changing its fatty acid profile. In conclusion, bacteria-inoculated BSF larvae develop AMPs in hemolymph which exhibit weak antibacterial activities. The methanol extracts of BSF can be produced in large quantities using larvae and have strong antibacterial activity which is attributed to lauric acid and some unknown compounds.
A Systematic Review of Mortality Associations in Patients who Develop Tracheoinnominate Artery Fistula Following Tracheostomy
Authors: Ward Katherine , Hinchman-Dominguez Daniela , Stokes Laura , Norton Elizabeth L. , Narveson Joel R. , Punja Viren P. 
Published: January 2024

Objective Tracheoinnominate artery fistulas (TIFs) are a rare but deadly complication of tracheostomy. Tracheoinnominate artery fistula cases in the literature were summarized in order to understand mortality associations. Methods MEDLINE was searched for studies reporting individual characteristics of patients with TIFs after tracheostomy, excluding cases without tracheostomy or with additional procedures at the tracheostomy site. This study followed PRISMA guidelines. Results 121 TIF patients from 18 case series and 46 case reports were included. The median age was 40 years, and 52.9% were male. The overall mortality rate was 64.5%. There were differences in mortality between cases that presented initially with vs without sentinel bleeding (odds ratio [OR] .34; CI [confidence interval] .16-.73; P = .006). The mortality rate also differed in whether or not the tracheostomy cuff was over-inflated for temporary hemostasis during resuscitation (OR 3.57 (CI 1.57-8.09); P = .002). Treatment compared to no treatment had lower mortality rates (OR .11 (CI 0.04-.32); P < .001); no differences were found if treatment was endovascular vs open surgical. Conclusions Mortality is a major concern after detection of a TIF and resuscitation paired with endovascular or open surgical intervention is imperative. Rapidly investigating sentinel bleeds and intervening upon hemorrhage with temporary cuff over inflation may lead to improved outcomes.