bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiorenale uitkomsten van diabetes mellitus type 2 tijdens behandeling met een sulfonureumderivaat in de Nederlandse praktijk
Authors: D.A. Stehouwer Coen , H. Serné Erik , de Jong Hilda J.I. , A. Overbeek Jetty , Palmen Jan 
Published: October 2023

SamenvattingInleidingHet is onbekend in hoeverre het risico op cardiovasculaire complicaties verhoogd is bij mensen met diabetes mellitus type 2 die niet voldoen aan de criteria voor een zeer hoog risico op hart- en vaatziekten, en die conventioneel behandeld worden met een sulfonureumderivaat (SU-derivaat).MethodeDe gegevens voor deze gematchte cohortstudie zijn verkregen uit het PHARMO Datanetwerk uit de eerste en tweede lijn in Nederland. De onderzoeksperiode liep van 1 januari 2013 tot en met 31 december 2019. Patiënten met diabetes mellitus type 2 die niet binnen de nieuwe richtlijn voor diabetes mellitus type 2 en een zeer hoog risico op hart- en vaatziekten vielen, werden ingedeeld in twee groepen: één groep met 'meerdere risicofactoren' (MRF) op basis van risicofactoren in de NHG CVRM Standaard, en één groep zonder aanvullende risicofactoren (non-RF). Het risico op verschillende cardiorenale complicaties afzonderlijk en een samengesteld eindpunt (hartfalen, myocardinfarct, beroerte, perifeer arterieel vaatlijden, niertransplantatie, dialyse, > 50% daling van de eGFR-waarde en overlijden) werd onderzocht vanaf de start van een SU-derivaat en vergeleken met een gematchte diabetesvrije populatie. ResultatenIn de 6.148 patiënten in de MRF-groep was de incidentie van het samengestelde cardiorenale eindpunt 13 (95% CI, 9-18) per 1.000 patiëntjaren. Vergeleken met de diabetesvrije populatie was dit risico significant verhoogd (gecorrigeerde hazard- ratio 3,6; 95% CI, 2,1-6,3). Ook in de 3.219 patiënten in de non-RF-populatie was zowel de incidentie als de gecorrigeerde hazardratio voor het samengestelde cardiorenale eindpunt significant verhoogd.ConclusieOndanks conventionele behandeling met SU-derivaten en CVRM-management hebben mensen met diabetes mellitus type 2 − zowel met als zonder aanvullende cardiovasculaire risicofactoren − een verhoogd risico op cardiorenale complicaties.
The effect of the Katz parameter on node ranking, with a medical application
Authors: Rehm Hunter , Matar Mona , Rombach Puck , McIntyre Lauren 
Published: October 2023

AbstractThe Medical Extensible Dynamic Probabilistic Risk Assessment Tool (MEDPRAT), developed by NASA, is an event-based risk modeling tool that assesses human health and medical risk during space exploration missions. The Susceptibility Inference Network (SIN), a sub-element of MEDPRAT, is a prototype model informed with data that represents the probabilities of medical conditions progressing from one to another and the expected quality time lost associated with the disease progression for each condition. The work presented in this paper aims to determine which conditions in the SIN have the greatest effect on MEDPRAT-predicted medical risk. Here, we propose to measure this expected quality time lost using a weighted version of Katz centrality and investigate the effect of the $$\alpha$$
α
-parameter on the lengths of walks that significantly affect the ranking of nodes. To do this, we introduce a tool to compare different centrality measures in their node rankings. This general tool is of independent interest, as it considers that a relative ranking of two nodes by a centrality measure is unreliable if their scores are within a margin of error. In particular, we find an upper bound on the lengths of the walks that determine the node ranking up to this margin of error. If an application imposes a realistic bound on possible walk lengths, this set of tools may help determine a suitable value for $$\alpha$$
α
.
Age-related changes in cuticular hydrocarbon bouquet and same-sex sexual behavior of mason bee males (Osmia cornuta and O. bicornis)
Authors: Seidelmann Karsten 
Published: October 2023

AbstractFinding a mate is the central task in the lives of many male insects. In many solitary bees, sexual competition between males is high due to monandry and a pronounced male-biased sex ratio. Males searching for females will inspect and mount any object of suitable size and habitus. Species, sex, and reproductive status are encoded in the bee’s bouquet of cuticular hydrocarbons (CHCs) and can only be identified at a short distance from the object encountered. In two species of mason bees, this CHC-based system for recognizing newly emerged, virgin females is not error-free. Newly emerged individuals of both sexes carry similar CHC bouquets, facilitating the confusion of newly emerged males with newly emerged, virgin females. Misidentification leads to same-sex sexual behavior by males seeking a mate. However, individuals of both sexes modify their CHC bouquet sex-specifically within a few days. The changes in the bouquet prevent further sexual harassment. In addition, within 3 days of emergence, males begin to release species-specific carboxylic acid esters, which may act as courtship-inhibiting pheromones to extend the range of their sex-specific scent tag. Due to the pronounced protandry of both species, SSB is restricted to the early flight season, when females are not yet present, and imposes no apparent cost on the two males involved.
Stimuli-Specific Inhibitory Control in Disorders Due to Addictive Behaviours: a Review of Current Evidence and Discussion of Methodological Challenges
Authors: Antons Stephanie , Müller Silke M. , Neumann Paul , Müller Astrid , Steins-Loeber Sabine 
Published: October 2023

Abstract
Purpose of Review
This systematic review focuses on stimuli-specific inhibitory control as measured with variations of Go/No-Go, Stroop, and Stop-Signal tasks including addiction-related cues. We aimed to identify whether individuals with tendencies towards behavioural addictions show stimulus-specific reductions in inhibitory control as assumed by recent theoretical models.

Recent Findings
The systematic literature search yielded 31 studies eligible for inclusion. Most studies focused on gaming disorder and problematic social networks use. Variants of the Go/No-Go task were most frequently used measures of inhibitory control. Findings on stimuli-specific reductions in inhibitory control are mixed. The studies differ considerably regarding used measures, sample characteristics, and study designs.

Summary
The large methodological heterogeneity across studies makes it almost impossible to draw any clear conclusions. Study designs, task characteristics, stimuli, and diagnostic instruments should be more standardised and used more consistently. We recommend to recruit clinical samples for studying stimuli-specific inhibitory control in behavioural addictions.
The Role of Psychopathic Traits and Supportive Parental Practices in Long-Term Juvenile Recidivism: a 10-Year Follow-Up
Authors: Westerveld Jet , Asscher Jessica J. , Deković Maja , Verweij Suzan , Weijters Gijs 
Published: October 2023

AbstractRecidivism rates of juvenile delinquents remain high despite numerous intervention efforts. Identifying factors that can predict (long-term) recidivism is therefore an important research issue. Knowledge on why juveniles re-offend is a key to effective interventions as it helps to identify factors most likely to be successful targets in intervention programs. A 10-year follow-up study prospectively examined whether psychopathic traits and supportive parental practices predicted the timing and frequency of recidivism in juvenile delinquents. Participants were 256 adolescents who were referred to treatment for serious antisocial behavior (72.4% male). Participants were between 12 and 18 years old at baseline (M = 15.9 years). Parents reported on juveniles’ psychopathic traits and supportive parental practices at baseline. At 10-year follow-up, the official recidivism data were collected. A substantial number of juveniles (86.3%) had recidivated at 10-year follow-up. Juvenile psychopathic traits and supportive parental practices did not incrementally predict the timing or frequency of recidivism over time over and beyond the static control variables gender and prior offenses. The present study confirms previous work suggesting that static risk factors gender and prior offenses are strongest predictors of recidivism.
Hydrocarbon generation potential and organic matter accumulation patterns in organic-rich shale during the mesoproterozoic oxygenation event: evidence from the Xiamaling formation shale
Authors: Miao Huan , Jiang Zhenxue , Tang Xianglu , Deng Ze , Zhang Chengju , Liang Zhikai , Shi Yuguang 
Published: October 2023

AbstractA significant deposition of black shales occurred during the Mesoproterozoic Oxygenation Event (MOE). In order to investigate the hydrocarbon generation potential and organic matter enrichment mechanism of these shale deposits, we studied the Xiamaling Formation shale in the North China region as a representative sample of the Mesoproterozoic shale. The research involved organic petrology, organic geochemistry, mineralogy, and elemental geochemistry. The following observations were made: (1) The depositional environment of the Xiamaling Formation shale can be categorized as either oxic or anoxic, with the former having shallow depositional waters and high deposition rates, while the latter has deeper depositional waters and slower deposition rates. (2) Anoxic shales exhibited significantly better hydrocarbon generation potential compared to shales deposited in oxic environments, although the latter still demonstrated high hydrocarbon generation potential. (3) Shales deposited in anoxic environments displayed higher paleoproductivity compared to those deposited in oxic environments. The high deposition rate in oxic environments slowed the decomposition and mineralization of organic matter, leading to the formation of high-quality shales. In contrast, the strong paleoproductivity, along with favorable preservation conditions, accounted for the high hydrocarbon potential of anoxic shales.
Factors associated with quality of life for cystic fibrosis family caregivers
Authors: Nesser Whitney , Snyder Scott , Driscoll Kimberly A. , Modi Avani C. 
Published: October 2023

AbstractCystic Fibrosis (CF) is a genetic and chronic disease affecting 32,100 people in the United States as of 2021, with a life expectancy of 56 years for people with CF (PwCF) born between 2018 and 2022. While there is extensive literature about cystic fibrosis, there are few studies examining the complexity and challenges experienced by family caregivers for PwCF. The aim of this study was to examine the Caregiver Quality of Life Cystic Fibrosis (CQOLCF) scale using data (N = 217) from two separate studies that used the scale to determine if its items represent multiple factors relevant to CF family caregiver QoL. Factor analysis was conducted on the Seven distinct factors were found with analysis of the CQOLCF. Factors were Existential Dread (12%), Burden (11%), Strain (7%), Support (7%), Positivity (6%), Finance (5%) and Guilt (3%). Study findings indicated it is important for healthcare providers and researchers who use the CQOLCF to be knowledgeable and aware of the multiple factors associated with quality of life in this population in addition to an overall quality of life score.
Erfahrungen mit wechselseitigen Untersuchungen (Peer-to-Peer): eine Querschnittsstudie unter Studierenden nach dem Untersuchungskurs
Authors: Scheins Hanna , Braun Gracia , Krumpholtz Yelda , Weltermann Birgitta 
Published: October 2023

Zusammenfassung
Hintergrund
Die körperliche Untersuchung ist eine medizinische Kernkompetenz. Die wechselseitigen Untersuchungen (Peer-to-Peer-Untersuchung [PPE]) in Kleingruppen mit teilweisem Entkleiden sind eine bewährte didaktische Methode. Studien deuten jedoch auf eine Beeinträchtigung der Lernprozesse durch PPE hin. In dieser Studie wurden Studierende nach ihren Erfahrungen mit PPE und Präferenzen für die Kurzentwicklung befragt.

Methoden
Diese webbasierte Querschnittsstudie befragte Medizinstudierende, die den Untersuchungskurs vor 2–4 Semestern absolviert hatten. Der Fragebogen erfasste soziodemografische Merkmale der Studierenden, ihre Erfahrungen mit wechselseitiger Untersuchung und ihre Präferenzen für die Verbesserung des Kursformats. Ein logistisches Regressionsmodell analysierte den Zusammenhang zwischen der Bereitschaft der Studierenden zu PPE und den Präferenzen für eine Weiterentwicklung des Lernformats.

Ergebnisse
Die Rücklaufquote betrug 39,5 % (n = 156), 73,4 % waren weiblich. Die Mehrheit stimmte PPE zu: Untersucht zu werden, ist eine wichtige Erfahrung für zukünftige Ärzte (96,5 %, n = 138), wechselseitiges Untersuchen ist eine geeignete Lehrmethode (89,5 %, n = 128) und das Wohlbefinden nahm im Kursverlauf zu (75,2 %, n = 107). Allerdings waren 13,3 % (n = 19) der Studierenden nicht bereit, sich untersuchen zu lassen, und 22,4 % (n = 32) waren nicht bereit, sich an ≥ 1 Körperteil untersuchen zu lassen. Über ≥ 1 Lernbeeinträchtigung durch PPE berichteten 31,5 % (n = 45) und 12,2 % (n = 17) fühlten sich zur Teilnahme gezwungen. Die Studierenden wählten durchschnittlich 5,8 von 14 (SD 1,9) der Vorschläge zur Anpassung des Kursformats. Studierende, die nicht bereit waren, an der wechselseitigen Untersuchung von ≥ 1 Körperregion teilzunehmen (23,8 %, n = 34), wünschten signifikant häufiger Kursmodifikationen: Training zuerst an Dummys (35,3 % vs. 12 %, p = 0,005) oder Schauspielpatienten (23,5 % vs. 5,6 %, p = 0,005), Raumtrennung durch Vorhänge (54,8 % vs. 17,9 %, p < 0,001) und gleichgeschlechtliche Tutoren (24,2 % vs. 1,9 %, p < 0,001).

Zusammenfassung
Die meisten Studierenden bewerten die wechselseitige Untersuchung positiv, doch waren etwa 30 % unzufrieden mit PPE. Optionen zur Weiterentwicklung des Lehrformats wurden insbesondere von den Studierenden bevorzugt, die sich mit einer wechselseitigen Untersuchung eher unwohl fühlten.
Slope susceptibility map for preventive measures against rainfall-induced slope failure
Authors: Rahardjo Harianto , Zhai Qian , Satyanaga Alfrendo , Li Yangyang , Rangarajan Saranya , Rahimi Arezoo 
Published: October 2023

AbstractRainfall-induced slope failures frequently occurs in many urban areas around the world especially due to the impact of the global warming. Some slope failures result in casualties that have negative impacts on urban sustainability. The slope failures are normally observed near slope surface within the unsaturated zone above the groundwater table. Hence, it is important to incorporate the unsaturated soil mechanics principles in analysing the slope stability during rainfall. This study focuses predominantly on the regional stability analyses of residual soils within the Jurong Formation and Bukit Timah Granite in Singapore. The objective of the study is to develop slope susceptibility map as part of preventive measures against extreme rainfall conditions. The slope susceptibility map was evaluated using 2-D numerical analyses of slopes with historical failure. The recently developed sustainable retaining structure system, GeoBarrier System (GBS) is investigated to understand its suitability as a preventive measure for critical slopes with high risk as identified from the slope susceptibility map. Using Transient Rainfall Infiltration (TRIGRS) and Grid-Based Regional Slope Stability Analysis (Scoops3D), the pore-water pressure distributions and factors of safety (FS) within each zone are determined. The results from slope susceptibility maps and 2-D numerical analyses are consistent. Moreover, the incorporation of GeoBarrier System on the critical slope is demonstrated to be an effective slope stabilization measure based on the numerical simulations of two-dimensional analyses.
Living artefacts for regenerative ecologies
Authors: Karana Elvin , McQuillan Holly , Rognoli Valentina , Giaccardi Elisa 
Published: October 2023

Abstract
Introduced in 2020, the notion of living artefacts encompasses biodesign outcomes that maintain the vitality of organisms such as fungi, algae, bacteria, and plants in the use of everyday artefacts, enabling new functions, interactions, and expressions within our daily lives. This paper situates living artefacts at the intersection of the sustainability discourse and more-than-human ontologies, illuminating the unprecedented opportunities that living artefacts present for regenerative ecologies. These ecologies are characterized by a fundamental inclination toward mutualism, creativity, and coevolution. In regenerative ecologies, the human-nature relationship transcends the binary distinction and it manifests as a single autopoietic system in which the constituent members collaboratively engage in the creation, transformation, and evolution of shared habitats. The paper outlines five pillars, supplemented by guiding questions and two illustrative cases, to aid designers in unlocking, articulating, and critically evaluating the potential of living artefacts for regenerative ecologies.
“Madame Wellington Koo”: a diplomatic wife and a Peranakan representing and socializing for Republican China
Authors: Shi Xia 
Published: October 2023

AbstractModern Chinese diplomatic histories rarely discuss the marriages of diplomats, leaving the impression that women made little impact on their husbands' careers. The extraordinary performance of Oei Hui-lan (1889–1992), wife of celebrated diplomat Wellington Koo (1888–1985), challenges this view. Hui-lan's contributions to diplomacy call our attention to the role played by Chinese diplomatic wives: as reception hostesses and embassy managers, they cultivated social relationships to facilitate diplomatic exchange. Hui-lan's story reminds us that to study modern diplomatic history solely through the lens of professionalization and institutionalization – while forgoing perspectives of gender and family – is insufficient to explain China's success in this period. Hui-lan's Peranakan family background in the Dutch East Indies (now Indonesia) equipped her with the financial assets and cosmopolitan upbringing to shine as a diplomatic wife. And yet, though she benefited from her overseas origins, Hui-lan had an uneasy relationship to her Chinese identity. Concealing the tension in her two autobiographies, Hui-lan later reconstructed her past, emphasizing her patriotism and ethnic Chineseness to befit her established position. Thus, her case also shows how the complicated process of identity rebuilding and selective adaptation played out for elite overseas Chinese women through their engagement with modern China.
A descriptive study of percutaneous injuries in National Healthcare Group POLYCLINICS dental clinics in Singapore from 2014 to 2020
Authors: Wong Vivian Yung Yee , Chao Priscilla Jang Shing , Lee Sabrina Poay Sian , Lee Eng Sing , Lang Lily Ren Lee , Koh Holy JR , Low Kenneth Meng Tze 
Published: October 2023

Abstract
Introduction
All dental staff face risk of percutaneous injuries (PCI)s. Blood-borne diseases may be transmitted to staff via contaminated sharp instruments. Hence there are significant impacts on staff when PCIs occur. Though a PCI is an occupational hazard, it is preventable.

Aim
This study aims to identify factors associated with PCIs among dental staff by evaluating the circumstances and staff designations involved.

Methods
PCIs were reported through an electronic incident reporting system from 2014 to 2020. Reports involved their nature and extent. Statistical analysis was carried out to find associations between factors such as injury site, type of instrument and staff designation.

Results
A total of 63 PCIs were included in this study. The type of instrument was found to be significantly associated with staff designation (p = 0.04, p < 0.05) with significantly more dental burs causing injury in dentists and more injuries caused by ‘other instruments’ in health attendants (p = 0.0083). Majority of PCIs occurred in dentists, then dental assistants and health attendants. Staff designation was significantly associated with the instance where PCIs occurred (p < 0.001). Dentists and dental assistants were more likely to sustain injuries during a dental procedure than before procedure and after procedure (p = 0.0167). The mean incidence of PCIs among our dentists was 15.6/100.

Conclusions
All dental staff are at risk of PCIs however dentists sustain the highest number of PCIs. Needles, dental burs and metal matrices are the top three instruments. Targeted interventions might help prevent/reduce PCIs.
Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration
Authors: Wang Zheng , Hu Xinli , Cui Peng , Kong Chao , Chen Xiaolong , Wang Wei , Lu Shibao 
Published: October 2023

AbstractNucleus pulposus (NP) inflammatory response can induce intervertebral disc degeneration (IVDD) by causing anabolic and catabolic disequilibrium of the extracellular matrix (ECM). This process is accompanied by the production of endogenous DNAs, then detectable by the DNA sensor cyclic GMP-AMP synthase (cGAS). cGAS recognizes these DNAs and activates the downstream adaptor protein, a stimulator of interferon genes (STING), initiating a cascade of inflammation responses through various cytokines. This evidence implies a crucial role of the cGAS-STING signaling pathway in IVDD. Additionally, it is suggested that this pathway could modulate IVDD progression by regulating apoptosis, autophagy, and pyroptosis. However, a detailed understanding of the role of cGAS-STING pathway in IVDD is still lacking. This review provides a comprehensive summary of recent advances in our understanding of the role of the cGAS-STING pathway in modulating inflammatory response in IVDD. We delve into the connection between the cGAS-STING axis and apoptosis, autophagy, and pyroptosis in IVDD. Furthermore, we discuss the therapeutic potential of targeting the cGAS-STING signaling pathway in IVDD treatment. Overall, this review aims to provide a foundation for future directions in IVDD treatment strategies.
Molecular landscape and functional characterization of centrosome amplification in ovarian cancer
Authors: Sauer Carolin M. , Hall James A. , Couturier Dominique-Laurent , Bradley Thomas , Piskorz Anna M. , Griffiths Jacob , Sawle Ashley , Eldridge Matthew D. , Smith Philip , Hosking Karen , Reinius Marika A. V. , Morrill Gavarró Lena , Mes-Masson Anne-Marie , Ennis Darren , Millan David , Hoyle Aoisha , McNeish Iain A. , Jimenez-Linan Mercedes , Martins Filipe Correia , Tischer Julia , Vias Maria , Brenton James D. 
Published: October 2023

AbstractHigh-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation, may have significant clinical utility in HGSOC. However, the prevalence of CA in HGSOC, its relationship to genomic biomarkers of CIN and its potential impact on therapeutic response have not been defined. Using high-throughput multi-regional microscopy on 287 clinical HGSOC tissues and 73 cell lines models, here we show that CA through centriole overduplication is a highly recurrent and heterogeneous feature of HGSOC and strongly associated with CIN and genome subclonality. Cell-based studies showed that high-prevalence CA is phenocopied in ovarian cancer cell lines, and that high CA is associated with increased multi-treatment resistance; most notably to paclitaxel, the commonest treatment used in HGSOC. CA in HGSOC may therefore present a potential driver of tumour evolution and a powerful biomarker for response to standard-of-care treatment.