bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Maintaining altered states of consciousness over repeated ketamine infusions may be key to facilitate long-lasting antidepressant effects: some initial lessons from a personalized-dosing single-case study
Authors: Reissmann Steffen , Hartmann Matthias , Kist Andreas , Liechti Matthias E. , Stocker Kurt 
Published: October 2023

BackgroundThe interest in psychoactive agents for treating mental disorders has gathered a growing body of scientific interest. However, research on the relationship between altered states of consciousness (ASCs) and ketamine’s antidepressant properties is still limited. Likewise, approaches to sustain early treatment success for the long-term are needed. Taking both aspects into account, the question arises whether the persistence of recurrent ASCs during the subsequent infusion sessions is crucial for the preservation of antidepressant effects during prolonged continued ketamine therapy.AimIn this case study we explored whether recurrent ASC experiences across a large number of infusions are associated with improved antidepressant effects in a single case study.MethodsA 62-year-old patient with treatment-resistant depression, who has been suffering from depressive episodes for over 20 years, was observed for 12 consecutive infusions across 16 weeks. ASCs during ketamine sessions were measured with the 5D-ASC, and pre/post-infusion depression scores with the BDI-II questionnaire. To emphasize psychoactive experiences a personalized antidepressant dose regimen was used.ResultsWe found a strong correlation between the experienced ASCs during ketamine infusions and the antidepressant effect: the stronger the ASCs overall, the stronger the resulting antidepressant effect. This correlation was consistently observed throughout the infusion series, independent of the number of ketamine sessions completed before. However, despite a personalized dose regimen, neither peri-infusion ASCs nor antidepressant effects could be established on a regular basis, leading overall to no improvement in treatment outcome.ConclusionMaintaining psychoactive effects over repeated ketamine infusions may be key to facilitate long-lasting antidepressant effects. However, for some depressed individuals maintenance of antidepressant effects and/or peri-infusion ASCs might not be achieved, even when personalized dosing is used.
Genome-Wide Identification and Expression Analysis of the Copper Transporter (COPT/Ctr) Gene Family in Kandelia obovata, a Typical Mangrove Plant
Authors: Hussain Quaid , Ye Ting , Li Sihui , Nkoh Jackson Nkoh , Zhou Qiao , Shang Chenjing 
Published: October 2023

The copper transporter (COPT/Ctr) gene family plays a critical part in maintaining the balance of the metal, and many diverse species depend on COPT to move copper (Cu) across the cell membrane. In Arabidopsis thaliana, Oryza sativa, Medicago sativa, Zea mays, Populus trichocarpa, Vitis vinifera, and Solanum lycopersicum, a genome-wide study of the COPT protein family was performed. To understand the major roles of the COPT gene family in Kandelia obovata (Ko), a genome-wide study identified four COPT genes in the Kandelia obovata genome for the first time. The domain and 3D structural variation, phylogenetic tree, chromosomal distributions, gene structure, motif analysis, subcellular localization, cis-regulatory elements, synteny and duplication analysis, and expression profiles in leaves and Cu were all investigated in this research. Structural and sequence investigations show that most KoCOPTs have three transmembrane domains (TMDs). According to phylogenetic research, these KoCOPTs might be divided into two subgroups, just like Populus trichocarpa. KoCOPT gene segmental duplications and positive selection pressure were discovered by universal analysis. According to gene structure and motif analysis, most KoCOPT genes showed consistent exon–intron and motif organization within the same group. In addition, we found five hormones and four stress- and seven light-responsive cis-elements in the KoCOPTs promoters. The expression studies revealed that all four genes changed their expression levels in response to copper (CuCl2) treatments. In summary, our study offers a thorough overview of the Kandelia obovata COPT gene family’s expression pattern and functional diversity, making it easier to characterize each KoCOPT gene’s function in the future.
Sustainable Pest Management Using Novel Nanoemulsions of Honeysuckle and Patchouli Essential Oils against the West Nile Virus Vector, Culex pipiens, under Laboratory and Field Conditions
Authors: Hikal Wafaa M. , Baz Mohamed M. , Alshehri Mohammed Ali , Bahattab Omar , Baeshen Rowida S. , Selim Abdelfattah M. , Alhwity Latifah , Bousbih Rabaa , Alshourbaji Maha Suleiman , Ahl Hussein A. H. Said-Al 
Published: October 2023

Essential oils are natural plant products that are very interesting, as they are important sources of biologically active compounds. They comprise eco-friendly alternatives to mosquito vector management, particularly essential oil nanoemulsion. Therefore, the aim of this study is to evaluate the effectiveness of 16 selected essential oils (1500 ppm) in controlling mosquitoes by investigating their larvicidal effects against the larvae and adults of the West Nile virus vector Culex pipiens L. (Diptera: Culicidae); the best oils were turned into nanoemulsions and evaluated under laboratory and field conditions. The results show that honeysuckle (Lonicera caprifolium) and patchouli (Pogostemon cablin) essential oils were more effective in killing larvae than the other oils (100% mortality) at 24 h post-treatment. The nanoemulsions of honeysuckle (LC50 = 88.30 ppm) and patchouli (LC50 = 93.05 ppm) showed significantly higher larvicidal activity compared with bulk honeysuckle (LC50 = 247.72 ppm) and patchouli (LC50 = 276.29 ppm) oils. L. caprifolium and P. cablin (100% mortality), followed by Narcissus tazetta (97.78%), Rosmarinus officinalis (95.56%), and Lavandula angustifolia (95.55%), were highly effective oils in killing female mosquitoes, and their relative efficacy at LT50 was 5.5, 5.3, 5.8, 4.1, and 3.2 times greater, respectively, than Aloe vera. The results of the field study show that the honeysuckle and patchouli oils and their nanoemulsions reduced densities to 89.4, 86.5, 98.6, and 97.0% at 24 h post-treatment, respectively, with persistence for eight days post-treatment in pools. Nano-honeysuckle (100% mortality) was more effective than honeysuckle oils (98.0%). Our results show that honeysuckle and patchouli oils exhibited promising larvicidal and adulticidal activity of C. pipiens.
The Implementation of Value for Money Quantitative Analysis on Infrastructure Projects in Indonesia
Authors: Jefry A. , Sagita Leni , Permana Andre 
Published: October 2023

Prior to the decision of the Government to opt for PPP (Public Private Partnership) for the procurement scheme of a public infrastructure project, it is necessary to conduct the Value for Money (VfM) analysis. VfM is defined by Moralos and Amekudzi (2008) as the optimum combination of all costs during the life cycle and the quality with the objective to meet the demand of users. According to Pangeran (2010), VfM has only been used in a few cases where the conventional methods, which does not take into account the risks of the project and only focus on the financial side, is more prevalent. Such test using conventional methods may risk on the non-optimal impact on the benefits of public procurement projects. In the context of procurement schemes for infrastructure projects in Indonesia, the Government has decided to use the BUMN (State-Owned Enterprise) assignment scheme to undertake the Trans Sumatera toll road project as mandated in the Perpres (Presidential Decree) no.100/2014. This paper will review the VfM test for Palembang Indralaya Toll Road (which is a section of the grand Trans Sumatra toll road) where the optimal VfM at 46% is generated at the BUMN assignment scheme higher than the PPP or APBN (State Budget) option.
Karakteristik Pasien Operasi Rekonstruksi Hipospadia yang Menjalani Terapi Oksigen Hiperbarik di RSUP Prof. Dr. R. D. Kandou dan RS Siloam Manado
Authors: Sukarno Irawan , Astram Ari , Hatibie Mendy J. , Langi Fredrik G. 
Published: October 2023

Abstract: Hypospadias is a congenital abnormality of urethral meatus in male. Hypospadias can be corrected by urethroplasty. Hyperbaric oxygen therapy (HBOT) can accelerate wound healing after surgery by increasing oxygenation, angiogenesis, and collagen synthesis. This study aimed to describe the characteristics of hypospadias reconstructive surgery patients who underwent hyperbaric oxygen therapy. This was a quantitative and descriptive study. Data were analyzed with SPSS ver 22.0. The results showed that from 20 patients who underwent reconstructive hypospadias surgery, 10 patients received HBOT as adjuvant therapy and 10 patients received conservative therapy post-surgery. The mean age of patients who underwent HBOT was 17.4±7.1 years old. The most frequent type of hypospadias found was subcoronal (35%), followed by the other types: glandular (20%), distal penile (10%), midshaft penile (10%), proximal penile (10%), penoscrotal (10%), and the least was scrotal (5%). All of the patients underwent urethroplasty with Sidik-Chaula and Manset Flap method. In conclusion, the mean age of patients who underwent HBOT was 17.4±7.1 years old, and the most frequent type of hypospadias found was subcoronal.
Keywords: hypospadias; hyperbaric oxygen therapy; characteristics of hypospadias patients

Abstrak: Hipospadia merupakan kelainan kongenital meatus uretra pada laki-laki. Hipospadia dapat dikoreksi dengan uretroplasti. Terapi oksigen hiperbarik (TOHB) dapat mempercepat penyembuhan luka pascaoperasi melalui peningkatan oksigenasi, angiogenesis, dan sintesis kolagen. Penelitian ini bertujuan untuk mengetahui karakteristik pasien rekonstruksi hipospadia yang menjalani TOHB. Jenis penelitian ialah deskriptif kuantitatif dengan alat analisis SPSS ver. 22.0. Hasil penelitian mendapatkan 20 pasien yang dilakukan operasi rekonstruksi hipospadia; 10 pasien menjalani TOHB dan 10 pasien menjalani terapi konservatif pasca pembedahan. Rerata usia pasien yang menjalani TOHB yaitu 17,4±7,1 tahun. Tipe hipospadia yang paling sering ialah subcoronal (35%), diikuti tipe glandular (20%), dan sisanya ialah tipe distal penile (10%), midshaft penile (10%), proximal penile (10%), penoscrotal (10%), dan yang paling sedikit ialah tipe scrotal (5%). Semua pasien menjalani operasi dengan metode Sidik-Chaula dan Manset Flap. Simpulan penelitian ini ialah rerata usia pasien yang menjalani TOHB ialah 17,4±7,1 tahun dengan tipe hipospadia yang paling sering ialah subcoronal.
Kata kunci: hipospadia; terapi oksigen hiperbarik; karakteristik pasien hipospadia
Photosynthetic protein-based simple cell receptive fields for detection of Café Wall illusions
Authors: Kako-Ito Shoko , Okada-Shudo Yoshiko 
Published: October 2023

Abstract
The differential response of the photosynthetic protein bacteriorhodopsin (bR) is highlighted as a means to emulate excitation and inhibition in neural response. We present a neuromorphic device that mimics a simple cell receptive field fabricated by patterning bR onto two transparent electrodes and sealing them with an electrolyte solution. The artificial receptive field is characterised as a bandpass filter that simultaneously emulates excitation and inhibition with a single element, requiring no bias power supply or external operating circuitry. The filter was employed to detect the Café Wall illusion, a type of orientation illusion, and demonstrated its ability to replicate the human eye’s perception using only the properties of the protein.
InAlN/GaN MISHEMTs with 120 nm T-Shape Recessed Gates on Silicon with Excellent mm-Wave Noise Performance
Authors: Gao Guangjie , Liu Zhihong , Hao Lu , Du Hanghai , Xing Weichuan , Zhou Hong , Zhang Weihang , Li Xiangdong , Zhang Jincheng , Hao Yue 
Published: October 2023

<p>Although there has been a large amount of research focusing on the noise performance of GaN HEMTs in L-bands and Ku-bands, few studies have focused specifically on the noise performance at mm-Wave frequencies.</p>
<p>In this letter, the fabricated 120 nm MISHEMTs exhibited a low minimum noise figure (<em>NF</em><sub>min</sub>) of 1.3 dB with an associated gain (<em>G</em><sub>a</sub>) of 7.7 dB at 30 GHz, and <em>NF</em><sub>min</sub> of 1.7 dB and <em>G</em><sub>a</sub> of 6 dB at 40 GHz, showing the lowest values of <em>NF</em><sub>min</sub> compared with the reported GaN HEMTs with the same gate length. </p>
O USO DE TÉCNICAS NÃO FARMACOLÓGICAS PARA ATENDIMENTO DE CRIANÇAS ANSIOSAS: UMA REVISÃO DE LITERATURA
Authors: Chaves Cynthia Coelho , Carvalho Marcio Santos , Ribeiro Michael Ranniery Garcia , Ribeiro Yuri Jivago Silva 
Published: October 2023

Introdução: O medo e a ansiedade durante os atendimentos odontológicos são as principais causas do comprometimento do atendimento, dessa forma a utilização do floral de bach auxilia no atendimento odontológico diminuindo os picos de ansiedade e por sua consequência melhorando o atendimento, dessa forma o objetivo do presente trabalho é relatar o uso do floral de bach como tratamento para ansiedade em atendimento odontopediátrico. Metodologia: trata-se de uma revisão da literatura utilizando artigos indexados nas bases de dados da Literatura Latino Americana em ciências da saúde e do caribe (LILACS), PubMed e Google Acadêmico, além da anamnese minuciosa, exames de imagem e registro fotográfico. Revisão de literatura: Métodos Não Farmacológicos em Odontopediatria (comportamental e cognitivo) são usados com o intuito de causar segurança e confiança ao paciente durante o atendimento, os métodos incluem: imagem pré-visita, dizer-mostrar-fazer, controle de voz e comunicação não verbal, remédio homeopático, reforço positivo e várias técnicas de distração. Somado a isso, o medo e a ansiedade no atendimento odontológico odontopediatrico são os principais fatores que geram comportamento não colaborador durante a avaliação clínica e execução do tratamento.Conclusão: A utilização do floral de Bach em conjunto com técnicas de condicionamento não farmacológicas se mostraram eficazes para o sucesso dos tratamentos odontológicos propostos, controlando o nível de ansiedade apresentada pelo paciente.
Evidence That the Occurrence Rate of Hot Jupiters around Sun-like Stars Decreases with Stellar Age
Authors: Miyazaki Shota , Masuda Kento 
Published: October 2023

Abstract
We investigate how the occurrence rate of giant planets (minimum mass > 0.3 M
Jup) around Sun-like stars depends on the age, mass, and metallicity of their host stars. We develop a hierarchical Bayesian framework to infer the number of planets per star (NPPS) as a function of both planetary and stellar parameters. The framework fully takes into account the uncertainties in the latter by utilizing the posterior samples for the stellar parameters obtained by fitting stellar isochrone models to the spectroscopic parameters, Gaia DR3 parallaxes, and 2MASS K
s-band magnitudes adopting a certain bookkeeping prior. We apply the framework to 46 Doppler giants found around a sample of 382 Sun-like stars from the California Legacy Survey catalog that publishes spectroscopic parameters and search completeness for all the surveyed stars. We find evidence that the NPPS of hot Jupiters (orbital period P = 1–10 days) decreases roughly in the latter half of the main sequence over the timescale of


(
Gyr
)

, while that of cold Jupiters (P = 1–10 yr) does not. Assuming that this decrease is real and caused by tidal orbital decay, the modified stellar tidal quality factor

Q

⋆

′

is implied to be


(

10

6

)

for a Sun-like main-sequence star orbited by a Jupiter-mass planet with P ≈ 3 days.
Observation of Alfvén Ion Cyclotron Waves in ICME Magnetic Clouds at 1 au
Authors: Dhamane Omkar , Pawaskar Vinit , Raghav Anil , Shaikh Zubair , D’Amicis Raffaella , Ghag Kalpesh , Kumbhar Kishor , Telloni Daniele , Nicolaou Georgios , Tari Prathmesh , Wicks Robert , Panchal Utsav , Sathe Bhagyashri , Pathare Prachi 
Published: October 2023

Abstract
Waves in plasma play an essential role in the energy transfer and plasma-heating processes. This article discusses the in situ observation of Alfvén ion cyclotron (AIC) waves and their characteristics within interplanetary coronal mass ejection (ICME) flux ropes. We analyzed 401 ICME flux ropes, observed by WIND spacecraft from 1995 to 2021 at 1 au. We found only five ICME flux ropes that show an explicit presence of AIC waves; two have normalized magnetic helicity σ

m
≤ −0.5, and the remaining three show σ

m
≥ 0.5 polarization. The angle between velocity and magnetic field (θ
VB) for σ

m
≤ −0.5 is <40°, whereas for σ

m
≥ 0.5, θ
VB > 140°. This result supports the existence of quasi-parallel and quasi-antiparallel left-handed polarized AIC waves within ICME flux ropes. We suggest that AIC waves are possibly triggered by (i) proton temperature anisotropy Tp
⊥/Tp
∥ > 1 driven by cyclotron instability and (ii) low-frequency Alfvén waves through the magnetohydrodynamic turbulent cascade. This study shows evidence of fluid and kinetic scales coupling in the ICME flux rope.
Jupiter Atmospheric Models and Outer Boundary Conditions for Giant Planet Evolutionary Calculations
Authors: Chen Yi-Xian , Burrows Adam , Sur Ankan , Arevalo Roberto Tejada 
Published: October 2023

Abstract
We present updated atmospheric tables suitable for calculating the post-formation evolution and cooling of Jupiter and Jupiter-like exoplanets. These tables are generated using a 1D radiative transfer modeling code that incorporates the latest opacities and realistic prescriptions for stellar irradiation and ammonia clouds. To ensure the accuracy of our model parameters, we calibrate them against the measured temperature structure and geometric albedo spectrum of Jupiter, its effective temperature, and its inferred internal temperature. As a test case, we calculate the cooling history of Jupiter using an adiabatic and homogeneous interior and compare with extant models now used to evolve Jupiter and the giant planets. We find that our model reasonably matches Jupiter after evolving a hot-start initial condition to the present age of the solar system, with a discrepancy in brightness temperature/radius within 2%. Our algorithm allows us to customize for different cloud, irradiation, and metallicity parameters. This class of boundary conditions can be used to study the evolution of solar system giant planets and exoplanets with more complicated interior structures and nonadiabatic, inhomogeneous internal profiles.
EMRI + TDE = QPE: Periodic X-Ray Flares from Star–Disk Collisions in Galactic Nuclei
Authors: Linial Itai , Metzger Brian D. 
Published: October 2023

Abstract
Roughly half of the quasiperiodic eruption (QPE) sources in galactic nuclei exhibit a remarkably regular alternating “long-short” pattern of recurrence times between consecutive flares. We show that a main-sequence star (brought into the nucleus as an extreme mass-ratio inspiral; EMRI) that passes twice per orbit through the accretion disk of the supermassive black hole (SMBH) on a mildly eccentric inclined orbit, each time shocking and ejecting optically thick gas clouds above and below the midplane, naturally reproduces observed properties of QPE flares. Inefficient photon production in the ejecta renders the QPE emission much harder than the blackbody temperature, enabling the flares to stick out from the softer quiescent disk spectrum. Destruction of the star via mass ablation limits the QPE lifetime to decades, precluding a long-lived AGN as the gaseous disk. By contrast, a tidal disruption event (TDE) naturally provides a transient gaseous disk on the requisite radial scale, with a rate exceeding the EMRI inward migration rate, suggesting that many TDEs should host a QPE. This picture is consistent with the X-ray TDE observed several years prior to the QPE appearance from GSN 069. Remarkably, a second TDE-like flare was observed from this event, starting immediately after detectable QPE activity ceased; this event could plausibly result from the (partial or complete) destruction of the QPE-generating star triggered by runaway mass loss, though other explanations cannot be excluded. Our model can also be applied to black hole–disk collisions, such as those invoked in the context of the candidate SMBH binary OJ 287.
Kinematics and Collimation of the Two-sided Jets in NGC 4261: VLBI Study on Subparsec Scales
Authors: Yan Xi , Lu Ru-Sen , Jiang Wu , Krichbaum Thomas P. , Shen Zhi-Qiang 
Published: October 2023

Abstract
We report multifrequency VLBI studies of the subparsec scale structure of the two-sided jets in the nearby radio galaxy NGC 4261. Our analyses include new observations using the source frequency phase referencing technique with the Very Long Baseline Array at 44 and 88 GHz, as well as archival data at 15 and 43 GHz. Our results show an extended double-sided structure at 43/44 GHz and provide a clear image of the nuclear region at 88 GHz, showing a core size of ∼0.09 mas and a brightness temperature of ∼1.3 × 109 K. Proper motions are measured for the first time in the two-sided jets, with apparent speeds ranging from 0.31 ± 0.14 c to 0.59 ± 0.40 c in the approaching jet and 0.32 ± 0.14 c in the receding jet. The jet-to-counterjet brightness ratio allows us to constrain the viewing angle to between ∼54° and 84° and the intrinsic speed to between ∼0.30 c and 0.55 c. We confirm the parabolic shape of the upstream jet on both sides of the central engine, with a power-law index of 0.56 ± 0.07. Notably, the jet collimation is found to be already completed at subparsec scales, with a transition location of about 0.61 pc, which is significantly smaller than the Bondi radius of 99.2 pc. This behavior can be interpreted as the initial confinement of the jet by external pressure from either the geometrically thick, optically thin advection-dominated accretion flows or the disk wind launched from it. Alternatively, the shape transition may also be explained by the internal flow transition from a magnetically dominated to a particle-dominated regime.
GRB 221009A with an Unconventional Precursor: A Typical Two-stage Collapsar Scenario?
Authors: Song Xin-Ying , Zhang Shuang-Nan 
Published: October 2023

Abstract
As the brightest gamma-ray burst (GRB) ever detected, GRB 221009A may offer a chance that reveals some interesting features that are hidden in those bursts that are not so bright. There seems to be a very weak emission with a flux of 10−8 ∼ 10−7 erg cm−2 s−1 between the first pulse (T
0 ∼ T
0 + 50 s; T
0 is the trigger time) and the main burst (which appears from T
0 + 180 s). Thus, the gap time between them is not really quiescent, and the first pulse could be taken as an unconventional precursor, which may provide a peculiar case study for GRB precursor phenomena. A two-stage collapsar scenario is proposed as the most likely origin for this burst. In this model, the jet for the precursor is produced during the initial core-collapse phase, and should be weak enough not to disrupt the star when it breaks out of the envelope, so that the fallback accretion process and the forming of the disk could continue. We present an approach in which the duration and flux both provide constraints on the luminosity (L
j) and the Lorentz factor at the breakout time (Γb) of this weak jet. The estimated L
j ≲ 1049 erg s−1 and Γb has an order of 10, which are well consistent with the theoretical prediction. Besides, the weak emission in the gap time could be interpreted as an MHD outflow due to a magnetically driven wind during the period from the proto-neutron-star phase to the forming of the accretion disk in this scenario.