bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation and genome sequence annotation of KillerTomato, a newly discovered cluster EE bacteriophage infecting
Microbacterium
Authors: Almahie Omer , Danklefsen Breanna , Graves R. Scott , Hepworth Sariah M. , Mathison Rylee T. , Sullivan Emily A. , Wood Paige R. , Bartholomew Skylar , Brewster Reganne , Hunt Dylan J. , Serna Carlos , Shurley Jack F. , Grinath Anna S. , Thomas Michael A. 
Published: October 2023

ABSTRACT

Discovered in Pocatello, Idaho, soil near a tomato garden, siphovirus KillerTomato infects
Microbacterium foliorum
NRRL B-24224. KillerTomato is a lytic cluster EE phage with a 17,442-bp genome and 68.6% GC content. Of 25 genes, 20 were assigned putative functions, including a putative tail assembly chaperone protein with a programmed frameshift and an endolysin.
The Odd One Out: Energy is Not Like Other Metrics
Authors: Anand Vaastav , Xie Zhiqiang , Stolet Matheus , De Viti Roberta , Davidson Thomas , Karimipour Reyhaneh , Alzayat Safya , Mace Jonathan 
Published: October 2023

Energy requirements for datacenters are growing at a fast pace. Existing techniques for making datacenters efficient focus on hardware. However, the gain in energy efficiency that can be achieved without making the applications energy-aware is limited. To overcome this limitation, recent work has proposed making the
software
running in datacenters energy aware. To do so, we must be able to track energy consumption at various granularities at the software level - (i) process level; (ii) application level; (iii) end-to-end request level.

Currently, existing software energy-tracking techniques primarily focus on tracking energy at the process or application level; only a few techniques track energy at an end-to-end request level. However, not tracking energy at an end-to-end request level can lead to false software optimizations and cause a decrease in energy efficiency.
To track energy at an end-to-end request level, we can leverage end-to-end tracking techniques for other metrics such as distributed tracing. However, we posit that energy cannot be treated as just another metric and that we cannot use existing frameworks without modifications. In this paper, we discuss how energy is different from other metrics and describe an energy-tracking workflow that leverages these differences and tracing techniques in order to track energy consumption of end-to-end requests.
Students Report on ACM MMSys 2022
Authors: Storås Andrea M. , Farahani Reza , Xu Xiaokun , Chellappa Sindhu , Fan Tzu-Yi , Hodžié Kerim , De Rus Arance Juan Antonio , Dasí Miguel Fernández , Vijayaratnam Melan , Ooi Chun Wei , Zhu Jingwen 
Published: October 2023

The 13th ACM Multimedia Systems Conference (and associated workshops: MMVE 2022, NOSSDAV 2022, GameSys 2022) happened from 14th -- 17th June 2022 in Athlone, Ireland. The MMSys conference is an essential forum for researchers in multimedia systems to present and share their latest research findings in multimedia systems. After two years of online and hybrid editions, MMSys was held onsite in the beautiful Athlone. Besides the many high-quality technical talks spread across different multimedia areas and the wonderful keynote talks, there were a few events targeted especially at students, such as mentoring sessions and the doctoral symposium. The social events were significant this year since they were the first opportunity in two years for multimedia researchers to meet colleagues, collaborators, and friends and discuss the latest hot topics while sharing a pint of Guinness or a glass of wine.
To encourage student authors to participate on-site, SIGMM has sponsored a group of students with Student Travel Grant Awards. Students who wanted to apply for this travel grant needed to submit an online form before the submission deadline. The selected students received either 1,000 or 2,000 USD to cover their airline tickets as well as accommodation costs for this event. Of the recipients, 11 were able to attend the conference. We asked them to share their unique experience attending MMSys'22. In this article, we share their reports of the event.
Yield and Mineral Composition among Mungbean [Vigna radiata (L.) R. Wilczek] Genotypes Grown in Different Agroecologies in East Africa
Authors: Mbeyagala Emmanuel K. , Karimi Rael. , Binagwa Papias H. , Amuge Esther S. , Vemula Anil Kumar. , Nair Ramakrishnan M. 
Published: October 2023

Mungbean [Vigna radiata (L.) R. Wilczek var. radiata] also referred to as green gram is a key crop especially in the marginal areas of East Africa. It is rich in micronutrients and protein and thus can help ameliorate malnutrition if incorporated into diets. This study was conducted to evaluate the performance of 26 fixed elite mungbean breeding genotypes for yield and micronutrient composition across different locations in East Africa (Uganda, Kenya, and Tanzania). The genotypes displayed significant variability for nutritional, phenology, and yield-related traits across test environments. Significant genotype effects were observed for most of the traits except for average yield per plant and dry matter content (

P

< 0.05). Random effect of environment was significant for all traits, and significant GXE was observed for all traits except for dry matter and iron content (

P

< 0.05). Moderate to high broad-sense heritability (H2) was found among traits except for dry matter content which was low (H2 = 10.4%). There was a significant and positive correlation between Fe and Zn (r = 0.58), and Fe and Ca (r = 0.46), indicating the potential to enhance these traits simultaneously through breeding and/or selection. However, the correlation between yield and nutrients (iron, zinc, and calcium) was negative. Environments KAT_SR_2019, KYM_LR_2020, and KYM_LR_2020 were found to be discriminating (informative) and representative of grain yield, calcium, and zinc content, respectively. Genotypes AVMU 1679, AVMU 1685, and AVMU1686 combined both stability and high micronutrient content, while the high yielding and stable genotypes were AVMU 1689, AVMU 1681, and AVMU 16102. The identified genotypes need to be assessed for farmer preference in on-farm trials before they can be recommended for release as new varieties. Additionally, these genotypes will be useful in future breeding efforts as donors aimed at developing nutrient-dense and high yielding mungbean varieties.
Reactive Transport Modelling of Elevated Dissolved Sulphide Concentrations in Sedimentary Basin Rocks
Authors: Xie Mingliang , Su Danyang , MacQuarrie Kerry T. B. , Mayer K. Ulrich 
Published: October 2023

Groundwater with total dissolved sulphide concentrations in excess of

1.0
×

10

−
4

mol

L

−
1

3

mg

L

−
1

is relatively common at intermediate depths in sedimentary basins. However, the mechanisms responsible for the formation and spatial distribution of these sulphidic waters in sedimentary basins, which have been affected by periods of glaciation and deglaciation, are not fully understood. Sulphate reduction rates depend on many factors including redox conditions, salinity, temperature, and the presence and abundance of sulphate, organic matter, and sulphate-reducing bacteria. Two-dimensional reactive transport modelling was undertaken to provide potential explanations for the presence and distribution of sulphidic waters in sedimentary basins, partially constrained by field data from the Michigan Basin underlying Southern Ontario, Canada. Simulations were able to generally reproduce the observed depth-dependent distribution of sulphide. Sulphate reduction was most significant at intermediate depths due to anoxic conditions and elevated sulphate concentrations in the presence of organic matter in waters with relatively low salinity. The simulations indicate that glaciation-deglaciation periods increase mixing of waters at this interfacial zone, thereby enhancing rates of sulphate reduction and the formation of sulphide. In addition, the simulations indicate that glaciation-deglaciation cycles do not significantly affect sulphide concentrations in low permeability units, even at shallow depths (e.g., 25 m), while concentrations in permeable units remain stable below depths of 500 m.
Mitochondrial Translocase TOMM22 Is Overexpressed in Pancreatic Cancer and Promotes Aggressive Growth by Modulating Mitochondrial Protein Import and Function
Authors: Haastrup Mary Oluwadamilola , Vikramdeo Kunwar Somesh , Anand Shashi , Khan Mohammad Aslam , Carter James Elliot , Singh Seema , Singh Ajay Pratap , Dasgupta Santanu 
Published: October 2023

Abstract

Pancreatic cancer has the worst prognosis among all cancers, underscoring the need for improved management strategies. Dysregulated mitochondrial function is a common feature in several malignancies, including pancreatic cancer. Although mitochondria have their own genome, most mitochondrial proteins are nuclear-encoded and imported by a multi-subunit translocase of the outer mitochondrial membrane (TOMM). TOMM22 is the central receptor of the TOMM complex and plays a role in complex assembly. Pathobiologic roles of TOMM subunits remain largely unexplored. Here we report that TOMM22 protein/mRNA is overexpressed in pancreatic cancer and inversely correlated with disease outcomes. TOMM22 silencing decreased, while its forced overexpression promoted the growth and malignant potential of the pancreatic cancer cells. Increased import of several mitochondrial proteins, including those associated with mitochondrial respiration, was observed upon TOMM22 overexpression which was associated with increased RCI activity, NAD+/NADH ratio, oxygen consumption rate, membrane potential, and ATP production. Inhibition of RCI activity decreased ATP levels and suppressed pancreatic cancer cell growth and malignant behavior confirming that increased TOMM22 expression mediated the phenotypic changes via its modulation of mitochondrial protein import and functions. Altogether, these results suggest that TOMM22 overexpression plays a significant role in pancreatic cancer pathobiology by altering mitochondrial protein import and functions.

Implications:
TOMM22 bears potential for early diagnostic/prognostic biomarker development and therapeutic targeting for better management of patients with pancreatic cancer.
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
Authors: Wang Zilu , Burigotto Matteo , Ghetti Sabrina , Vaillant François , Tan Tao , Capaldo Bianca D. , Palmieri Michelle , Hirokawa Yumiko , Tai Lin , Simpson Daniel S. , Chang Catherine , Huang Allan Shuai , Lieschke Elizabeth , Diepstraten Sarah T. , Kaloni Deeksha , Riffkin Chris , Huang David C.S. , Li Wai Suen Connie S.N. , Garnham Alexandra L. , Gibbs Peter , Visvader Jane E. , Sieber Oliver M. , Herold Marco J. , Fava Luca L. , Kelly Gemma L. , Strasser Andreas 
Published: October 2023

Abstract

Mutations in the tumor suppressor TP53 cause cancer and impart poor chemotherapeutic responses, reportedly through loss-of-function, dominant-negative effects and gain-of-function (GOF) activities. The relative contributions of these attributes is unknown. We found that removal of 12 different TP53 mutants with reported GOFs by CRISPR/Cas9 did not impact proliferation and response to chemotherapeutics of 15 human cancer cell lines and colon cancer–derived organoids in culture. Moreover, removal of mutant TP53/TRP53 did not impair growth or metastasis of human cancers in immune-deficient mice or growth of murine cancers in immune-competent mice. DepMap mining revealed that removal of 158 different TP53 mutants had no impact on the growth of 391 human cancer cell lines. In contrast, CRISPR-mediated restoration of wild-type TP53 extinguished the growth of human cancer cells in vitro. These findings demonstrate that LOF but not GOF effects of mutant TP53/TRP53 are critical to sustain expansion of many tumor types.

Significance:
This study provides evidence that removal of mutant TP53, thereby deleting its reported GOF activities, does not impact the survival, proliferation, metastasis, or chemotherapy responses of cancer cells. Thus, approaches that abrogate expression of mutant TP53 or target its reported GOF activities are unlikely to exert therapeutic impact in cancer.
See related commentary by Lane, p. 211 .
This article is featured in Selected Articles from This Issue, p. 201
The Feminine Irony of God
Authors: Battista Ludovico 
Published: October 2023

Abstract
It is not by chance that one of the most radical and enigmatic speeches in Erasmus’ production—the Encomium Moriae—was pronounced by a female character: Folly. This paper aims at interrogating Erasmus’ text not simply as the result of a carnivalesque spirit of suspension and derision of traditional order, or as a literary imitation of ancient satire, but as the expression of an original type of speech, serious from a religious point of view, that proposes itself as the alternative of the ‘male’ theological-philosophical logos, which it mocks. The Pauline and apocalyptic logic of the catastrophic inversion of the world’s values is reinterpreted by Erasmus in an Origenian lens as the revelation of the immense yet ‘foolish’ divine mercy that forgives everyone. Folly’s speech thus both condemns and forgives the foolishness of human sin. This paper will highlight both the corrosive and secularising potential of Erasmus’ scepticism, which harshly deconstructs the dogmatic naivety of human beliefs and attitudes, conceived as sin and therefore as foolishness; and Folly’s ironic exaltation of the world’s foolishness as redeemed by the maternal, ‘feminine’ and universal embrace of God’s forgiveness.
“The Burning Light of Phoebus”
Authors: Lauria Virginia 
Published: October 2023

Abstract
This essay examines a brief and little-known composition by Erasmus of Rotterdam, a poem dedicated to St. Genevieve. The presence of a votive composition dedicated to a saint is an atypical occurrence among Erasmus’ humanistic writings, which generally reduce the importance of saintly devotion and worship. However, the poem presents a captivating case that sheds light on Erasmus’ understanding of the role of women and the feminine element in his philosophy of Christ. In this context, it can be argued, women become the ideal vehicles for disseminating key tenets of his thought, including imitatio Christi, accommodatio, and Philosophia Christi. Furthermore, the text provides valuable insights into Erasmus’ stance on the veneration of saints, which consistently remains subordinate to his Christocentric perspective.
“The Place of Speaking for a Speaking That Has No Place”
Authors: Brandodoro Niccolò 
Published: October 2023

Abstract
The cultural environment of Charles V’s Spanish Empire, where Erasmianism met the Franciscan tradition, gave rise to an experimental quest for new religious practices that contributed to the diffusion of interiorizing meditative techniques. This essay focuses on mental prayer in the writings of Teresa of Avila, following the trail of Erasmianism and Franciscanism in spiritual literature. In order to measure the importance of such legacy, this research analyzes the relationship between the feminine discourse produced by Teresa of Avila and the male authority of different spiritual directors who watched over her camino de perfección. In particular, within a theoretical framework based on Michel de Certeau’s understanding of mysticism, it will be shown that Teresian practice is not structured as a rigorous method, but more properly as a real double bind between the need for regulated prayer and the impossibility to capture the mystical event.
Two Types of Applied History
Authors: Mens Jay 
Published: October 2023

Abstract
In recent years, a concerted effort has been made to build up and delineate a discipline of applied history. But there has been little discussion about what applied history is, how the discipline navigates a range of epistemological problems, and how applied history is distinct from other disciplines that use historical data and attend to matters of policy—particularly political science. This article considers some of these questions with respect to two common methods of applied history: analogy and genealogy. It applies these methods to understand two contemporary issues in the Middle East: the shadow war between Israel and Iran, and maritime tensions between Greece and Turkey.
On the Radar Detection of Cloud Seeding Effects in Wintertime Orographic Cloud Systems
Authors: Zaremba Troy J. , Rauber Robert M. , Girolamo Larry Di , Loveridge Jesse R. , McFarquhar Greg M. 
Published: October 2023

Abstract
Recent studies from the Seeded and Natural Orographic Wintertime Clouds: The Idaho Experiment (SNOWIE) demonstrated definitive radar evidence of seeding signatures in winter orographic clouds during three intensive operation periods (IOPs) where the background signal from natural precipitation was weak and a radar signal attributable to seeding could be identified as traceable seeding lines. Except for the three IOPs where seeding was detected, background natural snowfall was present during seeding operations and no clear seeding signatures were detected. This paper provides a quantitative analysis to assess if orographic cloud seeding effects are detectable using radar when background precipitation is present. We show that a 5-dB change in equivalent reflectivity factor Ze is required to stand out against background natural Ze variability. This analysis considers four radar wavelengths, a range of background ice water contents (IWC) from 0.012 to 1.214 g m−3, and additional IWC introduced by seeding ranging from 0.012 to 0.486 g m−3. The upper-limit values of seeded IWC are based on measurements of IWC from the Nevzorov probe employed on the University of Wyoming King Air aircraft during SNOWIE. This analysis implies that seeding effects will be undetectable using radar within background snowfall unless the background IWC is small, and the seeding effects are large. It therefore remains uncertain whether seeding had no effect on cloud microstructure, and therefore produced no signature on radar, or whether seeding did have an effect, but that effect was undetectable against the background reflectivity associated with naturally produced precipitation.

Significance Statement
Operational glaciogenic seeding programs targeting wintertime orographic clouds are funded by a range of stakeholders to increase snowpack. Glaciogenic seeding signatures have been observed by radar when natural background snowfall is weak but never when heavy background precipitation was present. This analysis quantitatively shows that seeding effects will be undetectable using radar reflectivity under conditions of background snowfall unless the background snowfall is weak, and the seeding effects are large. It therefore remains uncertain whether seeding had no effect on cloud microstructure, and therefore produced no signature on radar, or whether seeding did have an effect, but that effect was undetectable against the background reflectivity associated with naturally produced precipitation. Alternative assessment methods such as trace element analysis in snow, aircraft measurements, precipitation measurements, and modeling should be used to determine the efficacy of orographic cloud seeding when heavy background precipitation is present.
CD8 effector T cells enhance teclistamab response in BCMA-exposed and -naïve multiple myeloma
Authors: Firestone Ross S. , McAvoy Devin , Shekarkhand Tala , Serrano Edith , Hamadeh Issam , Wang Alice , Zhu Menglei , Qin Wei Ge , Patel Dhwani , Tan Carlyn R. , Hultcrantz Malin , Mailankody Sham , Hassoun Hani , Shah Urvi S. , Korde Neha , Maclachlan Kylee H. , Landau Heather J. , Scordo Michael , Shah Gunjan L. , Lahoud Oscar B. , Giralt Sergio , Murata Kazunori , Hosszu Kinga K. , Chung David J. , Lesokhin Alexander M. , Usmani Saad Z. 
Published: October 2023

Abstract
Teclistamab, a B-cell maturation antigen (BCMA)- and CD3–targeting bispecific antibody, is an effective novel treatment for relapsed/refractory multiple myeloma (R/RMM), but efficacy in patients exposed to BCMA-directed therapies and mechanisms of resistance have yet to be fully delineated. We conducted a real-world retrospective study of commercial teclistamab, capturing both clinical outcomes and immune correlates of treatment response in a cohort of patients (n = 52) with advanced R/RMM. Teclistamab was highly effective with an overall response rate (ORR) of 64%, including an ORR of 50% for patients with prior anti-BCMA therapy. Pretreatment plasma cell BCMA expression levels had no bearing on response. However, comprehensive pretreatment immune profiling identified that effector CD8+ T-cell populations were associated with response to therapy and a regulatory T-cell population associated with nonresponse, indicating a contribution of immune status in outcomes with potential utility as a biomarker signature to guide patient management.
Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway
Authors: Chen Zhen , Li Jun , Peng Huan , Zhang Mengli , Wu Xian , Gui Feng , Li Wei , Ai Fen , Yu Bo , Liu Yijue 
Published: October 2023

Abstract
Background
Ferroptosis plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). Meteorin-like/Meteorin-β (Metrnβ) is a protein secreted by skeletal muscle and adipose tissue and plays a role in cardiovascular diseases. However, its role in acute lung injury has not been elucidated.

Methods
In this study, we used an adenovirus (Ad) delivery system to overexpress or knockdown Metrnβ in lung tissue to examine the role of Metrnβ in LPS-induced acute lung injury.

Results
We found that ferroptosis was increased during LPS-induced ALI. The expression of Metrnβ was reduced in ALI lung tissue. Overexpression of Metrnβ in lung tissue alleviated LPS-induced lung injury, inflammation, and ferroptosis. Moreover, Metrnβ knockout in lung tissue accelerated LPS-induced ALI, inflammation, and ferroptosis. We also cultured MLE-12 cells and transfected the cells with Ad-Metrnβ or Metrnβ siRNA. Metrnβ overexpression ameliorated LPS-induced MLE cell death, inflammation and ferroptosis, while Metrnβ knockdown aggregated cell survival and decreased inflammation and ferroptosis. Moreover, we found that Metrnβ enhanced ferroptosis-related Gpx4 expression and reduced ferroportin and ferritin levels. Furthermore, we found that Metrnβ positively regulated SIRT1 transcription thus inhibited P53, increased SLC7A11 expression. When we used the ferroptosis inhibitor ferrostatin-1, the deteriorating effects of Metrnβ knockout were abolished in ALI mice. Moreover, SIRT1 knockout also abolished the protective effects of Metrnβ overexpression in vivo.

Conclusions
Taken together, Metrnβ could protect LPS-induced ALI by activating SIRT1-P53- SLC7A11 mediated ferroptosis inhibition.