bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodontists’ perceptions and attitudes toward the use of social media for professional purposes in Saudi Arabia
Authors: Alnufaiy Banna , Alzahrani Hanadi Ghurmallah , Alqahtani Abdullah Saad , Gufran Khalid , Alhamdan Alfaisal , Alhamdan Khalid 
Published: October 2023

Abstract
Background
There is a notable increase in the usage of social media platforms, especially for health communication, as more clinicians and patients count on this kind of technology. Therefore, this research aimed to investigate the perception and attitude toward social media (SM) use for professionalism and dental practice promotion among periodontal specialists working in Saudi Arabia (KSA).

Methods
Electronic surveys were distributed in person or online using WhatsApp, Snapchat or Email from October 2022 until March 2023. The questionnaire was targeting periodontists in KSA, and it consists of three parts: the first part includes sociodemographic and professional data; the second part asks about the daily usage of SM in dental practice; and the third part asks about the periodontist's opinion about SM usage. Descriptive data were presented as numbers and percentages. The association between the demographic variables and the means of periodontists’ opinions was tested using Pearson’s chi-square test. Any value equal to or less than 0.05 was considered statistically significant.

Results
A total of 121 responses were received from the periodontists. Most of the participants were in the 36–45 age group, with a percentage of 40.5%. In terms of gender, males made up 52.9% of the population, while females made up 47.1%, and the majority of the participants were consultants. The most common SM platform used by periodontists for daily using and dental practice promotion was Snapchat (56.2%), followed by Instagram and Twitter (54.5% and 49.6%, respectively). There was a significant difference in proportions among Twitter, Snapchat and TikTok between older and younger periodontists, with a p value < 0.05. There was no significant difference between the gender of the participants and their opinions regarding the usage of SM.

Conclusions
This study highlighted the effectiveness of SM in the promotion of dental practices and the discipline of periodontics, as more clinicians and patients rely on this kind of technology. These online platforms can improve periodontal practice in terms of dental health education, counseling, advertising, and oral health services.
Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study
Authors: Yoshida Kohei , Abe Tetsuya , Kanbara Kenji , Ueda Kento , Saka-Kouchi Yukie , Hasuo Hideaki 
Published: October 2023

Abstract
Background
Visceral hypersensitivity in functional dyspepsia can be localized or widespread, and there is no simple method of assessment. Measuring interoceptive accuracy at different sites provides an assessment of perceptual hypersensitivity to specific ecological phenomena. The purpose of this study was to characterize visceral hypersensitivity by comparing gastric sensory and cardiac perceptual tests in patients with postprandial distress syndrome and in healthy volunteers.

Methods
Sixteen patients with postprandial distress syndrome (age = 47.5 ± 17.4, all female) and 16 healthy volunteers (age = 43.3 ± 16.1, all female) participated in the study after a six-hour fast. Each participant answered questionnaires about physical and mental quality of life, depression and anxiety, tendency of alexithymia, and somatosensory amplification. After completing the questionnaire, the participants took the heartbeat tracking task and the five-minute water load test. We performed statistical analysis using the Mann–Whitney U test and Spearman’s rank correlation coefficient.

Results
Subjects with postprandial distress syndrome had a lower drinking capacity than healthy volunteers (postprandial distress syndrome = 360.9 ± 170.0 mL, healthy volunteers = 644.1 ± 297 mL, P = 0.009), but there was no significant difference in the heartbeat perception score (postprandial distress syndrome = 0.599 ± 0.175, healthy volunteers = 0.623 ± 0.181, P = 0.647). There was a negative correlation (r = − 0.509, P < 0.05) between drinking capacity and the heartbeat perception score in healthy volunteers, but no correlation in postprandial distress syndrome (r = − 0.156, P = 0.564). Heartbeat perception score did not correlate with psychological measures.

Conclusions
Compared with healthy volunteers, only the five-minute water load test values were reduced in patients with postprandial distress syndrome, and no difference was observed in the heartbeat tracking task. Combining the 5-minute water load test and the heart rate tracking task revealed a lost cardiac-gastric perceptual relationship in patients with postprandial distress syndrome that was not observed in healthy volunteers, suggesting that there is hypersensitivity in gastric interoceptive perceptual function. Performing sensory examinations at two different sites may be useful in clarifying whether visceral hypersensitivity is localized.

Trial registration
UMIN000057586. Registered11 March 2023(retrospectively registered).
Pediatric adrenocortical carcinoma: clinical features and application of neoadjuvant chemotherapy
Authors: Lin Yu , Yang Shen , Yang Wei , Cheng Haiyan , Chang Xiaofeng , Zhu Zhiyun , Feng Jun , Han Jianyu , Ren Qinghua , Chang Saishuo , Liu Shan , Yu Tong , Hou Boren , Li Pengfei , Meng Deguang , Zhang Xianwei , Qin Hong , Wang Huanmin 
Published: October 2023

Abstract
Objective
To summarize the clinical characteristics of children with adrenocortical carcinoma (ACC) and preliminarily explore the indications for and efficacy of neoadjuvant chemotherapy in certain patients.

Methods
The data of 49 children with adrenocortical tumors (ACT) in the past 15 years were retrospectively analyzed, and after pathology assessment using Weiss system grading, 40 children diagnosed with ACC were included. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and three-dimensional (3D) reconstruction of contrast-enhanced computed tomography data were used to evaluate the response to neoadjuvant chemotherapy.

Results
Forty patients (17 males, 23 females) with ACC were enrolled. Abnormal hormone levels were common in children with ACC (n = 31), and in terms of clinical presentation, sexual precocity was the most common (n = 14, 35.0%), followed by Cushing’s syndrome (n = 12, 30.0%). Seven of 40 children received neoadjuvant chemotherapy due to a maximum lesion diameter greater than 10 cm (n = 4), invasion of surrounding tissues (n = 2), intravenous tumor thrombus (n = 2), and/or distant metastasis (n = 2); 2 patients achieved partial response, and 5 had stable disease according to the RECIST 1.1 standard. Furthermore, 3D tumor volume reconstruction was performed in 5 children before and after neoadjuvant chemotherapy. Tumor volumes were significantly reduced in all 5 children, with a median volume reduction of 270 (interquartile range, IQR 83, 293) (range: 49–413) ml. After surgery with/without chemotherapy, the 5-year overall survival rate for all children was 90.0% (95% CI-confidence interval 80.0–100.0%), and the 5-year event-free survival rate was 81.5% (95% CI 68.0–97.7%).

Conclusion
In the diagnosis and treatment of pediatric ACC, a comprehensive endocrine evaluation is necessary to facilitate early diagnosis. Surgery and chemotherapy are important components of ACC treatment, and neoadjuvant chemotherapy should be considered for children with ACC who meet certain criteria, such as a large tumor, distant metastases, or poor general condition.
Functionality appreciation is associated with improvements in positive and negative body image in patients with an eating disorder and following recovery
Authors: Engel Manja M. , Woertman E. M. , Dijkerman H. C. , Keizer A. 
Published: October 2023

Abstract
Background
Research on body image in eating disorders has predominantly focused on negative body image, only recently shifting to positive body image. Findings suggest that enhancing positive body image can, amongst other things, serve as a protective mechanism against (re)developing a negative body image. One suggested way of enhancing positive body image is to focus on enhancing body functionality appreciation. Although studies show promising effects, this research is mainly conducted in non-clinical samples.

Methods
The current study investigated the levels of positive and negative body image in an online community sample of patients with an eating disorder (PAT, n = 227), patients recovered from an eating disorder (REC, n = 102) and controls (HC, n = 175) (self-reported diagnosis, not confirmed). In addition, we tested whether body functionality appreciation was associated with appearance dissatisfaction (negative body image) and body appreciation (positive body image).

Results
REC showed similar results to controls to most of the body image measures except for how much importance one places on their appearance (no different between REC and PAT), and how satisfied one is with certain body parts. For this measure, REC scored in-between PAT and HC. We further found functionality appreciation to be significantly associated with of both positive and negative body image, except for appearance evaluation in patients with an eating disorder.

Conclusions
This study showed a positive association between body functionality appreciation and positive body image and a negative association between body functionality appreciation and negative body image. Further research is required to investigate the effectiveness of interventions targeting body functionality appreciation in clinical settings.
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders
Authors: Bräuer Stefan , Rossi Marcello , Sajapin Johann , Henle Thomas , Gasser Thomas , Parchi Piero , Brockmann Kathrin , Falkenburger Björn H. 
Published: October 2023

AbstractThe alpha-synuclein (aSyn) seed amplification assay (SAA) can identify aSyn aggregates as indicator for Lewy body pathology in biomaterials of living patients and help in diagnosing Parkinson´s disease and dementia syndromes. Our objective was to confirm that qualitative results of aSyn SAA are reproducible across laboratories and to determine whether quantitative findings correlate with patient clinical characteristics. Therefore cerebrospinal fluid samples were re-analysed by aSyn SAA in a second laboratory with four technical replicates for each sample. Kinetic parameters derived from each aggregation curve were summarized and correlated with patient characteristics. We found that qualitative findings were identical between the two laboratories for 54 of 55 patient samples. The number of positive replicates for each sample also showed good agreement between laboratories. Moreover, specific kinetic parameters of the SAA showed a strong correlation with clinical parameters, notably with cognitive performance evaluated by the Montreal Cognitive Assessment. We concluded that SAA findings are highly reproducible across laboratories following the same protocol. SAA reports not only the presence of Lewy pathology but is also associated with clinical characteristics. Thus, aSyn SAA can potentially be used for patient stratification and determining the target engagement of aSyn targeting treatments.
Multi-faceted analysis reveals the characteristics of silk fabrics on a Liao Dynasty DieXie belt
Authors: Ge Ruochen , Cong Lili , Fu Yongping , Wang Bing , Shen Guiyun , Xu Bing , Hu Mingzhou , Yu Han , Zhou Jie , Yang Lu 
Published: October 2023

Abstract
The Liao Dynasty’s highly developed textile industry was characterized as “the best in the world” in ancient Chinese literature. This study analyzed two textiles on a 蹀躞 (DieXie) belt excavated from the No.1 Liao Dynasty noble tomb of Zhangjiayao Forest (Shenyang, China), with one wrapping around the leather belt (T1) and the other on the surface of a leather pouch hanging on the belt (X1). They were identified as silk based on structures by morphological observation and chemical components revealed by Fourier Transform Infrared spectroscopy (FTIR). Proteomics and enzyme-linked immunosorbent assay (ELISA) were used to investigate the animal origin of the silk, and the original color and dyestuffs of T1 were examined by liquid chromatography-mass spectrometer (LC-MS/MS). The results have shown that T1 consists of three layers of Bombyx mori silk plain fabric, and its original color was yellow-red dyed with madder and plants containing flavonoid dyeing tissue, consistent with the color of DieXie belts recorded in the ancient literature. The silk on the pouch is a layer of plain fabric, while the upper layer is embroidery on the Four-end-complex gauze, which was made of twisted Bombyx mori silk. We believe that the silk wrapping around the leather belt was to provide additional comfort and aesthetics after dyeing while protecting the leather, which is prone to warping and moisture. This study suggests that such silk fabrics with high specifications are one of the manifestations of the distinguished status of the tomb owner. The integration of various analytical methods on ancient silk fabrics enables us to learn various information about their textile forms, silk animal origins, colors and dyestuffs, revealing the highly developed silk waving techniques and prosperous costume culture of the Liao Dynasty.
Scenario-based classroom context mode: reshaping non-native teachers’ decision-making and pedagogical reasoning
Authors: Saeedian Sam , Ghaderi Ata 
Published: October 2023

AbstractTeacher decision-making and pedagogical reasoning have been extensively investigated in the last two decades. However, there is a scarcity of research that examines the two constructs together in one single study. This study was an attempt to address this gap by implementing a teacher education course using the self-evaluation of teacher talk (SETT) framework that aimed to reshape the decision-making and pedagogical reasoning of ten non-native teachers. Data were collected over a 10-week period through Camtasia, which facilitated video-stimulated recall sessions. Conversation analysis was employed to analyze the interactions in classroom context between the learners and the novice teachers and the interactions between the novices and the first researcher-as-a-participant or experienced teacher. The findings showed that the novices relied on the SETT-oriented metalanguage to justify their decisions after the teacher education course (POST-TEC). In addition, although in the PRE-TEC phase, they lost their temper and codeswitched because of frustration when facing learners’ reticence, they used a number of useful interactive decisions such as avoiding teacher echoes and on-the-spot corrections during discussions in the POST-TEC. It can be concluded that examining the SETT modes separately contributes to our richer understanding of classroom discourse, as each mode has its own specific pedagogic goals that teachers should pay attention to in their classroom decisions. Suggestions for further research and implications for making the decision-making and pedagogical reasoning of language teachers more explicit are provided.
The iBLAD study: patient-reported outcomes in bladder cancer during oncological treatment: a multicenter national randomized controlled trial
Authors: Taarnhøj Gry Assam , Johansen Christoffer , Carus Andreas , Dahlrot Rikke Hedegaard , Dohn Line Hammer , Hjøllund Niels Henrik , Knudsen Mark Bech , Tolver Anders , Lindberg Henriette , Pappot Helle 
Published: October 2023

Abstract
Background
Patient-reported outcomes (PROs) are getting widely implemented, but little is known of the impact of applying PROs in specific cancer diagnoses. We report the results of a randomized controlled trial (RCT) of the active use of PROs in patients with locally advanced or metastatic bladder cancer (BC) undergoing medical oncological treatment (MOT) with focus on determining the clinical effects of using PROs during chemo- or immunotherapy compared to standard of care.

Methods
We recruited patients from four departments of oncology from 2019 to 2021. Inclusion criteria were locally advanced or metastatic BC, initiating chemo- or immunotherapy. Patients were randomized 1:1 between answering selected PRO-CTCAE questions electronically once weekly with a built-in alert-algorithm instructing patients of how to handle reported symptoms as a supplement to standard of care for handling of side effects (intervention arm (IA)) vs standard procedure for handling of side effects (control arm (CA)). No real-time alerts were sent to the clinic when PROs exceeded threshold values. Clinicians were prompted to view the completed PROs in the IA at each clinical visit. The co-primary clinical endpoints were hospital admissions and treatment completion rate. Secondary endpoints were overall survival (OS), quality of life (EORTC’s QLQ-C30 and QLQ-BLM30) and dose reductions.

Results
228 patients with BC were included, 76% were male. 141 (62%) of the patients had metastatic disease. 51% of patients in the IA completed treatment vs. 56% of patients in the CA, OR 0.83 (95% CI 0.47–1.44, p = 0.51). 41% of patients in the IA experienced hospitalization vs. 32% in the CA, OR 1.48 (95% CI 0.83–2.65, p = 0.17). OS was comparable between the two arms (IA: median 22.3mo (95% CI 17.0-NR) vs. CA: median 23.1mo (95% CI 17.7-NR). Patient and clinician compliance was high throughout the study period (80% vs 94%).

Conclusions
This RCT did not show an effect of PRO on completion of treatment, hospitalizations or OS for BC patients during MOT despite a high level of patient and clinician compliance. The lack of real-time response to alerts remains the greatest limitation to this study.
Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
Authors: Sanchis-Alfonso Vicente , Beser-Robles María , Ten-Esteve Amadeo , Ramírez-Fuentes Cristina , Alberich-Bayarri Ángel , Espert Raúl , García-Larrea Luis , Martí-Bonmatí Luis 
Published: October 2023

Abstract
Background
This study investigates the functional brain connectivity in patients with anterior knee pain (AKP). While biomechanical models are frequently employed to investigate AKP, it is important to recognize that pain can manifest even in the absence of structural abnormalities. Leveraging the capabilities of functional magnetic resonance imaging (fMRI), this research aims to investigate the brain mechanisms present in AKP patients.

Methods
Forty-five female subjects (24 AKP patients, 21 controls) underwent resting-state fMRI and T1-weighted structural MRI. Functional brain connectivity patterns were analyzed, focusing on pain network areas, and the influence of catastrophizing thoughts was evaluated.

Results
Comparing patients and controls, several findings emerged. First, patients with AKP exhibited increased correlation between the right supplementary motor area and cerebellum I, as well as decreased correlation between the right insula and the left rostral prefrontal cortex and superior frontal gyrus. Second, in AKP patients with catastrophizing thoughts, there was increased correlation of the left lateral parietal cortex with two regions of the right cerebellum (II and VII) and the right pallidum, and decreased correlation between the left medial frontal gyrus and the right thalamus. Furthermore, the correlation between these regions showed promising results for discriminating AKP patients from controls, achieving a cross-validation accuracy of 80.5%.

Conclusions
Resting-state fMRI revealed correlation differences in AKP patients compared to controls and based on catastrophizing thoughts levels. These findings shed light on neural correlates of chronic pain in AKP, suggesting that functional brain connectivity alterations may be linked to pain experience in this population.

Relevance statement
Etiopathogenesis of pain in anterior knee pain patients might not be limited to the knee, but also to underlying alterations in the central nervous system: cortical changes might lead a perpetuation of pain.

Key points
• Anterior knee pain patients exhibit distinct functional brain connectivity compared to controls, and among catastrophizing subgroups.
• Resting-state fMRI reveals potential for discriminating anterior knee pain patients with 80.5% accuracy.
• Functional brain connectivity differences improve understanding of pain pathogenesis and objective anterior knee pain identification.

Graphical Abstract
Pangenomics of the cichlid species (Oreochromis niloticus) reveals genetic admixture ancestry with potential for aquaculture improvement in Kenya
Authors: Mwaura John G. , Wekesa Clabe , Kelvin Kiprotich , Paul Ang’ienda , Ogutu Philip A. , Okoth Patrick 
Published: October 2023

Abstract
Background
Nile tilapia has a variety of phenotypes suitable for aquaculture farming, yet its entire gene pool with potential for breeding climate ready strains in resource-limited settings remains scanty and poorly documented. SNP calling has become increasingly popular in molecular genetic studies due to their abundance and precision in estimating and identifying an organism’s genetic makeup. SNPs are versatile in trait-specific breeding, which, in contrast to pedigree breeding, is affordable and speeds up genetic advancement by allowing animals to be used as parents sooner.

Results
Clustering analysis revealed a strong correlation between the experimental sample, Oreochromis niloticus, Oreochromis aureus and Betta splendens. Three other species indicated evolutionary independence. Comparative genomics identified similarities between fishes with common genetic and evolutionary ancestry, allowing for better adaptation to local environmental conditions. Some of the selected genes exhibiting substantial effect on immunity include: Prxs, MMR1 like, ZMYM4-like partial; stress-reactive genes including: PALLD-like gene, LPLBAG6-like and growth-related genes including: NF1x like, PEDF and CL like. Experimental sample, O. niloticus, O. aureas and Danio rerio, can hybridize in their natural environments bringing about genetic admixture ancestry that hybridizes new genes which confer beneficial phenotypes.

Conclusion
Breeding for specific traits could be a useful addition to aquaculture to allow expansion of the ecological niche and genetic base for tilapia. Some of the beneficial genes that can be hybridized include Slc25a24 and Slc12member 10, tandem duplicate 1, for salinity tolerance and Abca1, bcl2a and mylk13 for hypoxia tolerance. Breeders should introduce beneficial traits into fish breeds to ensure they are climate ready and able to weather climate shocks. This will allow aquaculture to contribute to food and nutrition security in line with SDG2 and improve the economic status of fish-farming communities in the Global South countries.