bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muslims’ Motivation to Patronize Wasiyyah (Islamic Will) Services: Does religiosity Acts as a Moderator in the Relationships?
Authors: Mursidi Amalina , Muhammad Nasir Nur I'ffah , Razali Siti Salwani , Maulan Suharni 
Published: December 2023

Frozen assets in the country may be alleviated via wasiyyah services, which has long been considered a possible solution in Malaysia. However, despite the relevance of wasiyyah services in Malaysia, the penetration rate remains low. Self-determination and satisfaction in patronizing wasiyyah services are the focus of this research. There was also an investigation into how religiosity moderates the relationship between self-determination and satisfaction. The research framework consists of 8 hypotheses that predict four direct relationships and four moderation effects. The model used the principle of self-determination to explain the relationships. This research focuses on Muslim consumers in Malaysia who have already patronized wasiyyahservices. The data was gathered using an online survey, and 180 valid data were used to validate the study model. Data analysis was conducted using SPSS v27 and SmartPLS 4.0. The results stated that SDT constructs which are autonomy and relatedness have significant and positive and influence over satisfaction in patronizing wasiyyah services. However, competence did not have positive and significant influence over satisfaction. Furthermore, no moderation effect of religiosity could be found in this study. Findings suggest that religiosity has not moderated the relationship between SDT constructs and satisfaction. It is intended that this research can provide insights for industry players to enhance and develop sustainable marketing strategies to entice more Muslims to utilize the wasiyyah services, which might ultimately help in resolving the frozen asset problems.
Eksplorasi Kontekstual Bagi Pengukuhan Hafazan Ayat Mutashabihat Lafaz Dalam Kalangan Pelajar Tahfiz
Authors: Ahmad Abd Muhaimin 
Published: December 2023

Ayat mutashabihat lafaz merupakan ayat al-Quran yang berulang dengan lafaz yang hampir sama tetapi berbeza sama ada secara pendahuluan (taqdim) atau pengakhiran (ta’khir), penambahan (ziyadah) atau pengurangan (naqs) dan penukaran (ibdal) huruf atau kalimah. Mutashabihat lafaz yang berlaku ini sering berlaku dalam satu kisah yang sama di dalam al-Quran, namun ia berbeza dari sudut surah dan juga ayat. Isu ini menuntut kepada kajian terpeinci dari sudut perbezaan kontekstual (siyaq) dalam memahami pentafsiran ayat-ayat mutashabihat lafaz tersebut. Justeru, objektif kajian ini adalah untuk menganalisis aspek kontekstual dalam memahami pentafsiran perbezaan lafaz dan kalimah yang berlaku di dalam ayat-ayat mutashabihat lafaz terpilih. Kajian ini dibina berdasarkan metodologi kualitatif yang menggunakan kaedah pemerhatian dalam memilih sebahagian ayat-ayat mutashabihat lafaz sebagai bahan kajian dan seterusnya menggunakan kaedah analisis teks terhadap kitab-kitab tafsir dan karya-karya berkaitan dalam mengenal pasti aspek kontekstual dalam memahami pentafsiran yang mendasari perbezaan yang berlaku dalam ayat-ayat tersebut. Antara dapatan penting kajian ini ialah terdapat beberapa jenis kontekstual yang mempengaruhi perbezaan lafaz dalam ayat-ayat mutashabihat lafaz iaitu; kontekstual umum yang dibawa oleh surah, kontekstual khas yang dibawa oleh potongan tema kumpulan ayat dan kontekstual khusus dibawa oleh sesuatu ayat. Pemahaman kontekstual ini dapat membantu secara khusus pelajar aliran tahfiz yang menghadapi kesukaran dalam mengingati ayat–ayat mutashabihat lafaz yang memerlukan kaedah khusus untuk mengingatinya, di samping ia dapat membantu umat Islam secara umumnya dalam memahami makna perbezaan lafaz ayat al-Quran melalui perbezaan kontekstual yang berlaku.
Comportamiento de la caries dental en pacientes con discapacidad que acuden a Clínica Dei Bambini Portoviejo y su impacto económico
Authors: Holguín Pico Alexandra Betzabeth , Alcívar García Melania del Consuelo 
Published: December 2023

Introducción; La caries es una de las patologías dentales más frecuentes a nivel mundial, produce destrucción del tejido dentario de manera progresiva; en el mundo existen miles de personas que padecen algún tipo de discapacidad, los cuales presentan mala higiene y enfermedades bucales severas debido a la poca o nula visita al odontólogo. Objetivo. El objetivo de este estudio es determinar el comportamiento de la caries y su impacto económico en los pacientes que padecen discapacidad. Metodología. En este estudio se tomó como población a los pacientes con discapacidad que acuden a clínica Dei Bambini ciudad de Portoviejo, entre el año 2019 y enero del año 2023; obteniendo una muestra de 42 pacientes, que fueron seleccionados bajo los criterios de inclusión y exclusión; obteniendo los datos a través de la red anonimizada de historias clínicas de clínica Dei Bambini Portoviejo. Resultados. los resultados han sido tabulados y expuestos a través del sistema informático Microsoft Excel. Se evidenció que el 100% de los pacientes con discapacidad presentaron caries dental independientemente del estatus económico, debido en mayor relevancia a la dieta, aseo después de cada comida y visitas al dentista anuales; el impacto económico en los pacientes que padecen discapacidad frente a los costos de los tratamientos dentales es negativo, solo el 21% de los pacientes accedió al tratamiento dental. Conclusiones. Se concluye que el impacto económico en los pacientes con discapacidad en relación con los costos de los tratamientos dentales es negativo, en este estudio de un total de 42 pacientes, solo 9 accedieron al tratamiento oportuno ya que, si contaban con capacidad de pago, el restante grupo de 33 pacientes no realizó ningún tipo de tratamiento refiriendo no tener dinero para pagar los tratamientos dentales. Área de estudio general: Odontología. Área de estudio específica: Odontología. Tipo de estudio: Artículos originales / Original articles.
Predicting long-term prognosis after percutaneous coronary intervention in patients with acute coronary syndromes: a prospective nested case-control analysis for county-level health services
Authors: Lu Yue , Wang Yaqian , Zhou Bo 
Published: December 2023

PurposeWe aimed to establish and authenticate a clinical prognostic nomogram for predicting long-term Major Adverse Cardiovascular Events (MACEs) among high-risk patients who have undergone Percutaneous Coronary Intervention (PCI) in county-level health service.Patients and methodsThis prospective study included Acute Coronary Syndrome (ACS) patients treated with PCI at six county-level hospitals between September 2018 and August 2019, selected from both the original training set and external validation set. Least Absolute Shrinkage and Selection Operator (LASSO) regression techniques and logistic regression were used to assess potential risk factors and construct a risk predictive nomogram. Additionally, the potential non-linear relationships between continuous variables were tested using Restricted Cubic Splines (RCS). The performance of the nomogram was evaluated based on the Receiver Operating Characteristic (ROC) curve analysis, Calibration Curve, Decision Curve Analysis (DCA), and Clinical Impact Curve (CIC).ResultsThe original training set and external validation set comprised 520 and 1,061 patients, respectively. The final nomogram was developed using nine clinical variables: Age, Killip functional classification III-IV, Hypertension, Hyperhomocysteinemia, Heart failure, Number of stents, Multivessel disease, Low-density Lipoprotein Cholesterol, and Left Ventricular Ejection Fraction. The AUC of the nomogram was 0.79 and 0.75 in the training set and external validation set, respectively. The DCA and CIC validated the clinical value of the constructed prognostic nomogram.ConclusionWe developed and validated a prognostic nomogram for predicting the probability of 3-year MACEs in ACS patients who underwent PCI at county-level hospitals. The nomogram could provide a precise risk assessment for secondary prevention in ACS patients receiving PCI.
Prospective clinical validation of the Empatica EmbracePlus wristband as a reflective pulse oximeter
Authors: Gerboni Giulia , Comunale Giulia , Chen Weixuan , Lever Taylor Jessie , Migliorini Matteo , Picard Rosalind , Cruz Marisa , Regalia Giulia 
Published: December 2023

IntroductionRespiratory diseases such as chronic obstructive pulmonary disease, obstructive sleep apnea syndrome, and COVID-19 may cause a decrease in arterial oxygen saturation (SaO2). The continuous monitoring of oxygen levels may be beneficial for the early detection of hypoxemia and timely intervention. Wearable non-invasive pulse oximetry devices measuring peripheral oxygen saturation (SpO2) have been garnering increasing popularity. However, there is still a strong need for extended and robust clinical validation of such devices, especially to address topical concerns about disparities in performances across racial groups. This prospective clinical validation aimed to assess the accuracy of the reflective pulse oximeter function of the EmbracePlus wristband during a controlled hypoxia study in accordance with the ISO 80601-2-61:2017 standard and the Food &amp; Drug Administration (FDA) guidance.MethodsHealthy adult participants were recruited in a controlled desaturation protocol to reproduce mild, moderate, and severe hypoxic conditions with SaO2 ranging from 100% to 70% (ClinicalTrials.gov registration #NCT04964609). The SpO2 level was estimated with an EmbracePlus device placed on the participant's wrist and the reference SaO2 was obtained from blood samples analyzed with a multiwavelength co-oximeter.ResultsThe controlled hypoxia study yielded 373 conclusive measurements on 15 subjects, including 30% of participants with dark skin pigmentation (V–VI on the Fitzpatrick scale). The accuracy root mean square (Arms) error was found to be 2.4%, within the 3.5% limit recommended by the FDA. A strong positive correlation between the wristband SpO2 and the reference SaO2 was observed (r = 0.96, P &lt; 0.001), and a good concordance was found with Bland–Altman analysis (bias, 0.05%; standard deviation, 1.66; lower limit, −4.7%; and upper limit, 4.8%). Moreover, acceptable accuracy was observed when stratifying data points by skin pigmentation (Arms 2.2% in Fitzpatrick V–VI, 2.5% in Fitzpatrick I-IV), and sex (Arms 1.9% in females, and 2.9% in males).DiscussionThis study demonstrates that the EmbracePlus wristband could be used to assess SpO2 with clinically acceptable accuracy under no-motion and high perfusion conditions for individuals of different ethnicities across the claimed range. This study paves the way for further accuracy evaluations on unhealthy subjects and during prolonged use in ambulatory settings.
Surgical outcomes of endoscopic thyroidectomy approaches for thyroid cancer: a systematic review and network meta-analysis
Authors: Li Xiaosong , Ding Wei , Zhang Hong 
Published: December 2023

ObjectivesThis network meta-analysis assesses the outcomes of seven endoscopic approaches, offering valuable insights for researchers and practitioners in choosing the best method for thyroid cancer patients.MethodsA systematic literature search was conducted in the PubMed, Embase and Web of Science databases up to March 2023. The analysis included seven endoscopic approaches, with a focus on their respective outcomes through network meta-analysis.ResultsThis meta-analysis included 44 studies involving 8,672 patients. The axillo-bilateral breast approach (ABBA) and unilateral axillo-breast approach (UABA) showed advantages in terms of reduced operative time compared to other approaches (MD = 19.66 minutes, 95% CI = -31.66 to 70.98; MD = 30.32 minutes, 95% CI = -1.45 to 62.09, respectively). The UABA and anterior chest approach (ACA) exhibited superiority in controlling intraoperative bleeding (MD = -3.37 mL, 95% CI = -22.58 to 15.85; MD = -13.77 mL, 95% CI = -28.85 1.31, respectively). UABA and ACA also showed advantages in reducing hospital stays (MD = -0.39 days, 95% CI = -1.48 to 0.71; MD = -0.26 days, 95% CI = -1.33 to 0.81, respectively). The transoral approach (OA) yielded results comparable to those of conventional open thyroidectomy (COT) and outperformed other endoscopic surgeries with regards to lymph node retrieval and metastatic lymph node assessment. For the stimulated serum thyroglobulin (TG) levels, no significant difference was observed between bilateral axillo-breast approach (BABA) and OA compared to COT. However, chest-breast approach (CBA) showed significantly lower levels than COT (MD=-0.40 ng/ml, 95% CI =-0.72 to -0.09). Patients in the gasless unilateral transaxillary approach (GUA) group experienced a significant improvement in cosmetic satisfaction (MD=-2.08, 95% CI =-3.35 to -0.82). Importantly, no significant difference was observed in the incidence of surgical complications between endoscopic thyroidectomy and COT.ConclusionEndoscopic thyroid surgery is a safe and effective choice for thyroid cancer patients. Different approaches have their advantages, allowing personalized selection based on the patient’s needs. ABBA and UABA have shorter operative times, while UABA and ACA excel at controlling bleeding and shortening hospital stays. OA shows promise for lymph node assessment. These findings contribute to the growing evidence supporting endoscopic methods, expanding treatment options for thyroid cancer patients.
Associations of metabolic dysfunction-associated fatty liver disease and hepatic fibrosis with bone mineral density and risk of osteopenia/osteoporosis in T2DM patients
Authors: Zhang Wei , Li Yuhua , Li Shangjian , Zhou Jingqi , Wang Kai , Li Zhibin , Chen Ning , Chen Xueqin 
Published: December 2023

BackgroundExisting evidence on the associations of liver steatosis and fibrosis with bone mineral density (BMD) and risk of osteopenia/osteoporosis was limited with conflicting results. We aimed to evaluate the associations of metabolic dysfunction-associated fatty liver disease (MAFLD) and hepatic fibrosis with BMD and risk of osteopenia/osteoporosis in type 2 diabetes mellitus (T2DM) patients.MethodsBaseline information of an ongoing cohort of 249 T2DM patients in Xiamen, China was analyzed. MAFLD was defined as the presence of hepatic steatosis [diagnosed by either hepatic ultrasonography scanning or fatty liver index (FLI) score &gt;60] for T2DM patients. BMD was measured using dual-energy x-ray absorptiometry at total lumbar (L2–4), femur neck (FN), and total hip (TH) and was categorized as normal (T ≥ −1.0), osteopenia (−2.5 &lt; T &lt; −1.0), or osteoporosis (T ≤ −2.5) according to its minimum T-score.ResultsAmong the 249 T2DM patients, prevalence rates of MAFLD, osteopenia, and osteoporosis were 57.8%, 50.6%, and 17.7%, respectively. Patients with MAFLD had significantly higher BMD T-scores of L2–4, FN, and TH and the minimum as well as lower prevalence of osteoporosis than patients without MAFLD. Hepatic steatosis indices, including FLI score, fatty liver (FLI ≥ 60 or hepatic ultrasonography scanning), and MAFLD, were significantly and positively associated with all T-scores, while hepatic fibrosis index and FIB-4 score, but not NAFLD fibrosis score (NFS), were negatively associated with all T-scores. MAFLD was significantly associated with the decreased risk of osteopenia/osteoporosis and osteoporosis with unadjusted odds ratios (ORs) (95% CI) of 0.565 (0.324–0.987) and 0.434 (0.224–0.843) (both p-values &lt; 0.05), respectively. As for liver fibrosis, FIB-4 score, but not NFS, was significantly associated with elevated risk of osteoporosis with an unadjusted OR (95% CI) per SD increase of FIB-4 score of 1.446 (1.080–1.936, p-value = 0.013). Adjusting for potential confounding variables, especially body mass index, in the multivariable regression analyses, all associations of hepatic steatosis and fibrosis indices with BMD and risk of osteopenia/osteoporosis were not statistically significant.ConclusionMAFLD and hepatic fibrosis were not significantly associated with BMD and risk of osteopenia/osteoporosis independent of obesity. Nevertheless, screening and management of MAFLD and osteopenia/osteoporosis were still important for the prevention of fracture in T2DM patients.
Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis
Authors: Wei Jiaqi , Zhang Fenghua 
Published: December 2023

BackgroundIn recent years, the outbreak of COVID-19 caused by SARS-CoV-2 has been witnessed globally. However, the impact of SARS-CoV-2 infection on thyroid dysfunction and subclinical thyroid dysfunction remains unclear. Therefore, this meta-analysis aimed to assess the effects of SARS-CoV-2 infection on thyroid dysfunction and its relationship with the severity of COVID-19.MethodsWe systematically searched databases including PubMed, Willey Library, Embase, Web of Science, CNKI, Wanfang, and VIP. We focused on randomized controlled trials, case-control studies, and cohort studies published between December 2019 and August 2023, examining the association between SARS-CoV-2 infection and hypothyroidism, with a specific emphasis on the severity of the infection. The quality of the research was assessed using the Newcastle-Ottawa Scale (NOS), while statistical analysis was conducted using the meta and metafor packages in R 4.2.1 software.ResultsFor the meta-analysis, a total of eight articles were identified based on strict inclusion and exclusion criteria. For the association between SARS-CoV-2 infection and hypothyroidism, three studies (266 samples) comparing TSH levels of COVID-19 and control groups showed no difference in TSH levels [SMD=-0.04,95%CI(-1.22,1.15),P=0.95]. Additionally, two studies examining TT3 (a sample of 176 cases) and two studies examining TT4 (a sample of 176 cases) also showed no difference in TT3 and TT4 between the COVID-19 group and the control group, respectively. However, when evaluating the severity of COVID-19, six studies (565 samples) showed that TSH in the severe group was significantly lower than in the mild group [SMD = -0.55, 95% CI (-0.96, -0.14)], while FT3 was also lower in the severe group [SMD = -0.96, 95% CI (-1.24, -0.67)]. No noticeable differences were observed between the severe and mild groups in their TT3, FT4, and TT4 levels.ConclusionSARS-CoV-2 infection may have detrimental effects on thyroid function in individuals with severe symptoms. More research is needed to confirm and explore this relationship.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023486042.
A rhoptry protein, localizing in the bulb region of rhoptries, could induce protective immunity against Eimeria tenella infection
Authors: Shi Tuan-yuan , Zhou Si-han , Kong Ya-ru , Fu Yuan , Liu Yan , Yan Wen-chao , Zhou Yong-xue , Zhang Liang , Hao Li-li , Sun Hong-chao 
Published: December 2023

BackgroundRhoptry organelle proteins (ROPs) secreted by apicomplexan parasites play important roles during parasites invasion and survival in host cells, and are potential vaccine candidates against apicomplexan diseases. Eimeria tenella (E. tenella) is one of the most noteworthy apicomplexan species, which causes hemorrhagic pathologies. Although dozens of putative E. tenella ROP sequences are annotated, most ROP proteins are not well studied.MethodsIn this study, an E. tenella ROP21 gene was identified and the recombinant EtROP21 protein (rEtROP21) was expressed in Escherichia coli. The developmental expression levels, localization, and protective efficacy against E. tenella infection in chickens were studied.ResultsAn EtROP21 gene fragment with an open reading frame (ORF) of 981 bp was obtained from the Beijing strain of E. tenella. The rEtROP21 has a molecular weight of approximately 50 kDa and was recognized by rEtROP21-immunized mouse serum. Two specific protein bands, about 43 KDa and 95 KDa in size, were detected in the whole sporozoite proteins using the rEtROP21-immunized chicken serum. RT-qPCR analysis of the E. tenella ROP21 gene (EtROP21) revealed that its mRNA levels were higher in merozoites and sporozoites than in sporulated and unsporulated oocysts. Immunofluorescence and immunoelectron analyses showed that the EtROP21 protein predominantly localizes in the bulb region of rhoptries distributed at anterior, posterior, and perinuclear regions of E. tenella sporozoites. Immunization and challenge experiments revealed that immunizing chickens with rEtROP21 significantly increased their average body weight gain while decreasing mean lesion score and oocyst output (P &lt;0.05). When compared with the challenged control group, the rEtROP21-immunized group was associated with a significantly higher relative weight gain (90.2%) and a greater reduction in oocyst output (67%) (P &lt;0.05). The anticoccidial index of the rEtROP21-immunized group was 163.2. Chicken serum ELISA revealed that the levels of the specific anti- rEtROP21 antibody, IFN-γ, and IL-4 were significantly higher in the rEtROP21-immunized group than in the challenged control group (P &lt;0.05).ConclusionThese results indicate that rEtROP21 can induce a high level of specific immune response and it is a potential candidate for the development of vaccines against E. tenella infection in chickens.
Effect of transcranial static magnetic stimulation over unilateral or bilateral motor association cortex on performance of simple and choice reaction time tasks
Authors: Matsumoto Takuya , Watanabe Tatsunori , Ito Kanami , Horinouchi Takayuki , Shibata Sumiya , Kurumadani Hiroshi , Sunagawa Toru , Mima Tatsuya , Kirimoto Hikari 
Published: December 2023

BackgroundTranscranial static magnetic stimulation (tSMS) is a non-invasive brain stimulation technique that place a strong neodymium magnet on scalp to reduce cortical excitability. We have recently developed a new tSMS device with three magnets placed close to each other (triple tSMS) and confirmed that this new device can produce a stronger and broader static magnetic field than the conventional single tSMS. The aim of the present study was to investigate the effect of the conventional single tSMS as well as triple tSMS over the unilateral or bilateral motor association cortex (MAC) on simple and choice reaction time (SRT and CRT) task performance.MethodsThere were two experiments: one involved the conventional tSMS, and the other involved the triple tSMS. In both experiments, right-handed healthy participants received each of the following stimulations for 20 min on different days: tSMS over the unilateral (left) MAC, tSMS over the bilateral MAC, and sham stimulation. The center of the stimulation device was set at the premotor cortex. The participants performed SRT and CRT tasks before, immediately after, and 15 min after the stimulation (Pre, Post 0, and Post 15). We evaluated RT, standard deviation (SD) of RT, and accuracy (error rate). Simulation was also performed to determine the spatial distribution of magnetic field induced by tSMS over the bilateral MAC.ResultsThe spatial distribution of induced magnetic field was centered around the PMd for both tSMS systems, and the magnetic field reached multiple regions of the MAC as well as the sensorimotor cortices for triple tSMS. SD of CRT was significantly larger at Post 0 as compared to Pre when triple tSMS was applied to the bilateral MAC. No significant findings were noted for the other conditions or variables.DiscussionWe found that single tSMS over the unilateral or bilateral MAC did not affect performance of RT tasks, whereas triple tSMS over the bilateral MAC but not over the unilateral MAC increased variability of CRT. Our finding suggests that RT task performance can be modulated using triple tSMS.