bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projeto de automatização do processo de produção de comidas em rede de fast-food a partir de um sistema a eventos discretos
Authors: Dacca Danilo Patah , Aquino Pedro Bianco de , Kassab Vítor Aun 
Published: January 2024

O projeto de automação proposto visa aprimorar a eficiência da produção em um ambiente de fast-food, especificamente na fabricação de hambúrgueres, batatas fritas e nuggets. Utilizando a metodologia de Sistemas a Eventos Discretos (SED), a abordagem emprega uma arquitetura física que incorpora dispositivos de detecção, monitoramento, comando e atuação, todos conectados a um Controlador Lógico Programável (CLP). A norma IEC 61131-3 guia a programação dos CLPs, empregando a linguagem Ladder Diagram (LD) para traduzir os modelos de rede de Petri para a lógica de controle do sistema. A modelagem do comportamento do sistema é realizada por meio da metodologia Production Flow Schema (PFS) e redes de Petri, proporcionando uma representação visual clara dos subprocessos, incluindo a produção de cada item e os intertravamentos necessários. A validação do controle é executada por simulações utilizando o software PIPE 4.3, permitindo ajustes antes da conversão para LD. Os resultados esperados abrangem uma melhoria substancial na eficiência operacional. A automação busca garantir consistência na qualidade do produto, redução de erros e aumento da capacidade produtiva. Ao minimizar a intervenção humana, o sistema também pretende otimizar a produção, proporcionando benefícios tanto para a empresa quanto para a experiência do cliente. O desenvolvimento do projeto segue uma metodologia de cinco etapas, que englobam desde a definição da arquitetura física até o comissionamento das Entradas/Saídas no sistema real. A transcrição da Rede de Petri para a linguagem de programação é realizada por meio do isomorfismo, facilitando a implementação prática do controle. Em síntese, a integração de SED, metodologia PFS, modelagem de redes de Petri e programação conforme a norma IEC 61131-3 oferece uma abordagem robusta para o desenvolvimento de sistemas de automação complexos, proporcionando melhorias significativas na eficiência e na qualidade da produção em um ambiente de fast-food.
Comparative Effectiveness of PET and SPECT MPI for Predicting Cardiovascular Events After Kidney Transplant
Authors: Huck Daniel M. , Weber Brittany , Schreiber Brittany , Pandav Jay , Parks Sean , Hainer Jon , Brown Jenifer M. , Divakaran Sanjay , Blankstein Ron , Dorbala Sharmila , Trinquart Ludovic , Chandraker Anil , Di Carli Marcelo F. 
Published: January 2024

BACKGROUND:
Advanced chronic kidney disease is associated with high cardiovascular risk, even after kidney transplant. Pretransplant cardiac testing may identify patients who require additional assessment before transplant or would benefit from risk optimization. The objective of the current study was to determine the relative prognostic utility of pretransplant positron emission tomography (PET) and single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for posttransplant major adverse cardiovascular events (MACEs).

METHODS:
We retrospectively followed patients who underwent MPI before kidney transplant for the occurrence of MACE after transplant including myocardial infarction, stroke, heart failure, and cardiac death. An abnormal MPI result was defined as a total perfusion deficit >5% of the myocardium. To determine associations of MPI results with MACE, we utilized Cox hazard regression with propensity weighting for PET versus SPECT with model factors, including demographics and cardiovascular risk factors.

RESULTS:

A total of 393 patients underwent MPI (208 PET and 185 SPECT) and were followed for a median of 5.9 years post-transplant. Most were male (58%), median age was 58 years, and there was a high burden of hypertension (88%) and diabetes (33%). A minority had abnormal MPI (n=58, 15%). In propensity-weighted hazard regression, abnormal PET result was associated with posttransplant MACE (hazard ratio, 3.02 [95% CI, 1.78–5.11];
P
<0.001), while there was insufficient evidence of an association of abnormal SPECT result with MACE (1.39 [95% CI, 0.72–2.66];
P
=0.33). The explained relative risk of the PET result was higher than the SPECT result (R
2
0.086 versus 0.007). Normal PET was associated with the lowest risk of MACE (2.2%/year versus 3.6%/year for normal SPECT;
P
<0.001).

CONCLUSIONS:
Kidney transplant recipients are at high cardiovascular risk, despite a minority having obstructive coronary artery disease on MPI. PET MPI findings predict posttransplant MACE. Normal PET may better discriminate lower risk patients compared with normal SPECT, which should be confirmed in a larger prospective study.
Coronary Sinus Narrowing Improves Coronary Microcirculation Function in Patients With Refractory Angina: A Multicenter Prospective INROAD Study
Authors: Tebaldi Matteo , Campo Gianluca , Ugo Fabrizio , Guarracini Stefano , Marrone Andrea , Clò Stefano , Abdirashid Mohamed , Di Mauro Michele , Rametta Francesco , Di Marco Massimo , Cocco Marta , Marchini Federico , Penzo Carlo , Erriquez Andrea , Banai Shmuel , Biscaglia Simone 
Published: January 2024

BACKGROUND:
The underlying mechanisms responsible for the clinical benefits following coronary sinus narrowing and pressure elevation remain unclear. The present study aims to investigate whether coronary sinus narrowing improves the indexes of coronary microcirculatory function.

METHODS:
Patients with refractory angina who had a clinical indication for reducer implantation underwent invasive physiological assessments before and 4 months after the procedure. The primary outcome was the change in the values of the index of microcirculatory resistance. Secondary end points included changes in coronary flow reserve and the resistive resistance ratio values. Angina status was assessed with the Canadian Cardiology Society class and the Seattle Angina Questionnaire.

RESULTS:

Twenty-four patients with a history of obstructive coronary artery disease and prior coronary revascularization (surgical and percutaneous) treated with reducer implantation were enrolled, and 21 of them (87%) underwent repeated invasive coronary physiological assessment after 4 months. The index of microcirculatory resistance values decreased from 33.35±19.88 at baseline to 15.42±11.36 at 4-month follow-up (
P
<0.001; mean difference, −17.90 [95% CI, −26.16 to −9.64]). A significant (≥20% from baseline) reduction of the index of microcirculatory resistance was observed in 15 (71.4% [95% CI, 47.8%–88.7%]) patients. The number of patients with abnormal index of microcirculatory resistance (≥25) decreased from 12 (57%) to 4 (19%;
P
=0.016). Coronary flow reserve increased from 2.46±1.52 to 4.20±2.52 (mean difference, 1.73 [95% CI, 0.51–2.96]). Similar findings were observed for resistive resistance ratio values. Overall, 16 patients (76.1%) had an improvement of 1 Canadian Cardiology Society class. Seattle Angina Questionnaire summary score increase of around 3 points (3.01 [95% CI, 1.39–4.61]).

CONCLUSIONS:
Coronary sinus reduction implantation is associated with a significant improvement in the parameters of coronary microcirculatory function. These findings provide insights into the improvement of angina symptoms and may have implications for the treatment of coronary microvascular dysfunction.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT05174572.
Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure
Authors: Guirette Mélanie , Lan Jessie , McKeown Nicola M. , Brown Michael R. , Chen Han , de Vries Paul S. , Kim Hyunju , Rebholz Casey M. , Morrison Alanna C. , Bartz Traci M. , Fretts Amanda M. , Guo Xiuqing , Lemaitre Rozenn N. , Liu Ching-Ti , Noordam Raymond , de Mutsert Renée , Rosendaal Frits R. , Wang Carol A. , Beilin Lawrence J. , Mori Trevor A. , Oddy Wendy H. , Pennell Craig E. , Chai Jin Fang , Whitton Clare , van Dam Rob M. , Liu Jianjun , Tai E. Shyong , Sim Xueling , Neuhouser Marian L. , Kooperberg Charles , Tinker Lesley F. , Franceschini Nora , Huan TianXiao , Winkler Thomas W. , Bentley Amy R. , Gauderman W. James , Heerkens Luc , Tanaka Toshiko , van Rooij Jeroen , Munroe Patricia B. , Warren Helen R. , Voortman Trudy , Chen Honglei , Rao D.C. , Levy Daniel , Ma Jiantao ,   On behalf of the CHARGE Gene-Lifestyle Interactions Working Group
Published: January 2024

BACKGROUND:
The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.

METHODS:
We analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (n=35 660) and UK Biobank (n=91 622) and performed European population-specific and cross-population meta-analyses.

RESULTS:

We identified 3 loci in European-specific analyses and an additional 4 loci in cross-population analyses at
P
interaction
<5e−8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency, 0.03) and the DASH diet score (
P
interaction
=4e−8;
P
for heterogeneity, 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (
P
interaction
=9.4e−7) and 0.20±0.06 mm Hg (
P
interaction
=0.001) in Cohorts for Heart and Aging Research in Genomic Epidemiology and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants (
P
=4e−273) and cis-DNA methylation quantitative trait loci variants (
P
=1e−300). Although the closest gene for rs117878928 is
MTHFS
, the highest narrow sense heritability accounted by single nucleotide polymorphisms potentially interacting with the DASH diet score in this locus was for gene
ST20
at 15q25.1.

CONCLUSIONS:
We demonstrated gene-DASH diet score interaction effects on systolic BP in several loci. Studies with larger diverse populations are needed to validate our findings.
Design and Implementation of an Electronic Health Record‐Integrated Hypertension Management Application
Authors: Funes Hernandez Mario , Babakhanian Meghedi , Chen Tania P. , Sarraju Ashish , Seninger Clark , Ravi Vishnu , Azizi Zahra , Tooley James , Chang Tara I. , Lu Ying , Downing N. Lance , Rodriguez Fatima , Li Ron C. , Sandhu Alexander T. , Turakhia Mintu , Bhalla Vivek , Wang Paul J. 
Published: January 2024

Background
High blood pressure affects approximately 116 million adults in the United States. It is the leading risk factor for death and disability across the world. Unfortunately, over the past decade, hypertension control rates have decreased across the United States. Prediction models and clinical studies have shown that reducing clinician inertia alone is sufficient to reach the target of ≥80% blood pressure control. Digital health tools containing evidence‐based algorithms that are able to reduce clinician inertia are a good fit for turning the tide in blood pressure control, but careful consideration should be taken in the design process to integrate digital health interventions into the clinical workflow.

Methods
We describe the development of a provider‐facing hypertension management platform. We enumerate key steps of the development process, including needs finding, clinical workflow analysis, treatment algorithm creation, platform design and electronic health record integration. We interviewed and surveyed 5 Stanford clinicians from primary care, cardiology, and their clinical care team members (including nurses, advanced practice providers, medical assistants) to identify needs and break down the steps of clinician workflow analysis. The application design and development stage were aided by a team of approximately 15 specialists in the fields of primary care, hypertension, bioinformatics, and software development.

Conclusions
Digital monitoring holds immense potential for revolutionizing chronic disease management. Our team developed a hypertension management platform at an academic medical center to address some of the top barriers to adoption and achieving clinical outcomes. The frameworks and processes described in this article may be used for the development of a diverse range of digital health tools in the cardiovascular space.
Digital Health Interventions for Heart Failure Management in Underserved Rural Areas of the United States: A Systematic Review of Randomized Trials
Authors: Azizi Zahra , Broadwin Cassandra , Islam Sumaiya , Schenk Jamie , Din Natasha , Hernandez Mario Funes , Wang Paul , Longenecker Chris T. , Rodriguez Fatima , Sandhu Alex T. 
Published: January 2024

Background
Heart failure disproportionately affects individuals residing in rural areas, leading to worse health outcomes. Digital health interventions have been proposed as a promising approach for improving heart failure management. This systematic review aims to identify randomized trials of digital health interventions for individuals living in underserved rural areas with heart failure.

Methods and Results
We conducted a systematic review by searching 6 databases (CINAHL, EMBASE, MEDLINE, Web of Science, Scopus, and PubMed; 2000–2023). A total of 30 426 articles were identified and screened. Inclusion criteria consisted of digital health randomized trials that were conducted in underserved rural areas of the United States based on the US Census Bureau's classification. Two independent reviewers screened the studies using the National Heart, Lung, and Blood Institute tool to evaluate the risk of bias. The review included 5 trials from 6 US states, involving 870 participants (42.9% female). Each of the 5 studies employed telemedicine, 2 studies used remote monitoring, and 1 study used mobile health technology. The studies reported improvement in self‐care behaviors in 4 trials, increased knowledge in 2, and decreased cardiovascular mortality in 1 study. However, 3 trials revealed no change or an increase in health care resource use, 2 showed no change in cardiac biomarkers, and 2 demonstrated an increase in anxiety.

Conclusions
The results suggest that digital health interventions have the potential to enhance self‐care and knowledge of patients with heart failure living in underserved rural areas. However, further research is necessary to evaluate their impact on clinical outcomes, biomarkers, and health care resource use.

Registration

URL:
https://www.crd.york.ac.uk/prospero/
; Unique identifier: CRD42022366923.
On null models for temporal small-worldness in brain dynamics
Authors: Rossi Aurora , Deslauriers-Gauthier Samuel , Natale Emanuele 
Published: January 2024

Abstract
Brain dynamics can be modeled as a temporal brain network starting from the activity of different brain regions in functional magnetic resonance imaging (fMRI) signals. When validating hypotheses about temporal networks, it is important to use an appropriate statistical null model that shares some features with the treated empirical data. The purpose of this work is to contribute to the theory of temporal null models for brain networks by introducing the random temporal hyperbolic (RTH) graph model, an extension of the random hyperbolic (RH) graph, known in the study of complex networks for its ability to reproduce crucial properties of real-world networks. We focus on temporal small-worldness which, in the static case, has been extensively studied in real-world complex networks and has been linked to the ability of brain networks to efficiently exchange information. We compare the RTH graph model with standard null models for temporal networks and show it is the null model that best reproduces the small-worldness of resting brain activity. This ability to reproduce fundamental features of real brain networks, while adding only a single parameter compared with classical models, suggests that the RTH graph model is a promising tool for validating hypotheses about temporal brain networks.
Eucherius’ Enigmatic Formulas of Spiritual Knowledge
Authors: Toom Tarmo 
Published: January 2024

Abstract
Cassiodorus grouped Eucherius’ Formulae spiritalis intellegentiae with four other introductiones, all of which are supposedly about biblical interpretation. However, and despite its Preface, Eucherius’ treatise does not fit well with the other hermeneutical treatises. This article attempts to determine the alleged purpose of Eucherius’ Formulae and assess the interpretative advice that it provides. It is argued that Formulae is a compendium assisting one in a meditative lectio divinae.
Ghana Armed Forces’ Contributions to African-Led Peace Support Operations from 1990-2020
Authors: Salihu Naila , Aning Kwesi 
Published: January 2024

Abstract
Ghana’s role in African-led peace support operations (pso) is best situated within the first Economic Community of West African States Ceasefire Monitoring Group (ecomog) mission deployed in 1990 to Liberia. Ghana, and Nigeria, spearheaded this initiative at a time when regional interventions in intra-state conflicts had not been properly elaborated and UN collaboration with regional organizations in conflict interventions were underdeveloped. Through its multiple expanded contributions in Sierra Leone, La Côte d’Ivoire, Guinea Bissau, Mali and Gambia, Ghana’s experiences provide critical and important cognitive lessons in how a resource constrained state adapted to the changing operational environments of pso s. This paper explores Ghana’s contributions to ecowas pso s and argues that Ghana, though not a hegemon, has been a driving force behind some ecowas pso s. It argues that participation in pso s have provided opportunities through which Ghana has demonstrated and enhanced its influence and agency in regional affairs and the international system.
The Association Between the Albumin-Bilirubin Score and Contrast-Associated Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention
Authors: Chen Jun-Han , Zhang Li-Wei , Lin Zhi-Jie , Chen Xiao-Fang , Chen Li-Chuan , Wang Chang-Xi , Lin Kai-Yang , Guo Yan-Song 
Published: January 2024

The albumin-bilirubin (ALBI) score is considered an effective and convenient scoring system for assessing liver function. We hypothesized that the ALBI score was predictive of contrast-associated acute kidney injury (CA-AKI) and long-term mortality in patients undergoing elective percutaneous coronary intervention (PCI). We retrospectively observed 5629 patients undergoing elective PCI. Contrast-associated acute kidney injury is defined as a 50% or 0.3 mg/dl increase in baseline serum creatinine levels within 48 h of contrast exposure. The incidence of CA-AKI was 6.2% (n = 350). After adjusting for potential confounding factors, multivariate analysis showed that the ALBI score was an independent predictor of CA-AKI ( P = .002). A restricted cubic spline analysis confirmed approximately linear relationships between the ALBI score and risks of CA-AKI. Furthermore, at a median follow-up of 2.8 years, multivariate Cox regression analysis indicated that the ALBI score was an independent risk factor for long-term mortality ( P < .001). The ALBI score was closely related to the occurrence of CA-AKI and long-term mortality in patients who underwent elective PCI. This score might be useful for risk stratification in high-risk patient groups to predict CA-AKI.
The moral behaviour of single young women immigrants to Mandatory Palestine: Between nationalism, gender, and professionalism in social work
Authors: Shimei Nour 
Published: January 2024

Summary Migration has always constituted a meeting point of opportunity, risk, and vulnerability. Concerns surrounding the sex trafficking of women have caused moral panic since the mid-1800s and led to social workers’ preventive initiatives and interventions in Europe and the United States. This article explores a historical moment in which Henrietta Szold, who headed the Social Welfare Department in Mandatory Palestine in 1934, decided to send social workers to the Jaffa and Haifa ports to welcome young, single immigrant women from Germany in the light of rumours of the moral dangers they faced upon entering the country. This feminist historical study of social work employed qualitative analysis of archival texts to investigate the professional decision-making processes involved in sending a social worker to the Jaffa port and the results of the decisions that were made. Findings The findings trace the course of events that took place in 1934 using three categories: the rumours, their investigation, and the results and implications of the investigations. The findings point to intersections of nationalism, gender, and professionalism in social work. Applications This article contributes to the evolving knowledge on moral panic in social work and reveals the historical practice used in social work policy and interventions in facing moral panic regarding young women immigrants.
PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma
Authors: Balraj Alex Stanley , Muthamilselvan Sangeetha , Raja Rachanaa , Palaniappan Ashok 
Published: January 2024

Background Prostate adenocarcinoma (PRAD) is a common cancer diagnosis among men globally, yet large gaps in our knowledge persist with respect to the molecular bases of its progression and aggression. It is mostly indolent and slow-growing, but aggressive prostate cancers need to be recognized early for optimising treatment, with a view to reducing mortality. Methods Based on TCGA transcriptomic data pertaining to PRAD and the associated clinical metadata, we determined the sample Gleason grade, and used it to execute: (i) Gleason-grade wise linear modeling, followed by five contrasts against controls and ten contrasts between grades; and (ii) Gleason-grade wise network modeling via weighted gene correlation network analysis (WGCNA). Candidate biomarkers were obtained from the above analysis and the consensus found. The consensus biomarkers were used as the feature space to train ML models for classifying a sample as benign, indolent or aggressive. Results The statistical modeling yielded 77 Gleason grade-salient genes while the WGCNA algorithm yielded 1003 trait-specific key genes in grade-wise significant modules. Consensus analysis of the two approaches identified two genes in Grade-1 (SLC43A1 and PHGR1), 26 genes in Grade-4 (including LOC100128675, PPP1R3C, NECAB1, UBXN10, SERPINA5, CLU, RASL12, DGKG, FHL1, NCAM1, and CEND1), and seven genes in Grade-5 (CBX2, DPYS, FAM72B, SHCBP1, TMEM132A, TPX2, UBE2C). A RandomForest model trained and optimized on these 35 biomarkers for the ternary classification problem yielded a balanced accuracy ∼ 86% on external validation. Conclusions The consensus of multiple parallel computational strategies has unmasked candidate Gleason grade-specific biomarkers. PRADclass, a validated AI model featurizing these biomarkers achieved good performance, and could be trialed to predict the differentiation of prostate cancers. PRADclass is available for academic use at: https://apalania.shinyapps.io/pradclass (online) and https://github.com/apalania/pradclass (command-line interface).