bluuebunny/crossref_metadata_2025_split huggingface dataset:
The unique face of anxious depression: Increased sustained threat circuitry response during fear acquisition
Authors: Poplin Tate , Ironside Maria , Kuplicki Rayus , Aupperle Robin L. , Guinjoan Salvador M. , Khalsa Sahib S. , Stewart Jennifer L. , Victor Teresa A. , Paulus Martin P. , Kirlic Namik 
Published: October 2023

AbstractBackgroundSensitivity to threat with dysregulation of fear learning is thought to contribute to the development of psychiatric disorders, including anxiety disorders (AD) and major depressive disorder (MDD). However, fewer studies have examined fear learning in MDD than in AD. Nearly half of individuals with MDD have an AD and the comorbid diagnosis has worse outcomes. The current study used propensity matching to examine the hypothesis that AD+MDD shows greater neural correlates of fear learning than MDD, suggesting that the co-occurrence of AD+MDD is exemplified by exaggerated defense related processes.Methods195 individuals with MDD (N = 65) or AD+MDD (N=130) were recruited from the community and completed multi-level assessments, including a Pavlovian fear learning task during functional imaging.ResultsMDD and AD+MDD showed significantly different patterns of activation for [CSplus– CSminus] in the medial amygdala (ηp2=0.009), anterior insula (ηp2=0.01), dorsolateral prefrontal cortex (ηp2=0.002), dorsal anterior cingulate cortex (ηp2=0.01), mid-cingulate cortex (ηp2=0.01) and posterior cingulate cortex (ηp2=0.02). These differences were driven by greater activation to the CS+ in late conditioning phases in ADD+MDD relative to MDD.ConclusionsAD+MDD showed a pattern of increased sustained activation in regions identified with fear learning. Effects were consistently driven by the threat condition, further suggesting fear signaling as the emergent target process. Differences emerged in regions associated with salience processing, attentional orienting/conflict, and self-relevant processing. These findings help to elucidate the fear signaling mechanisms involved in the pathophysiology of comorbid anxiety and depression, thereby highlighting promising treatment targets for this prevalent treatment group.
Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: A computational modeling study
Authors: Madden Lauren R. , Graham Robert D. , Lempka Scott F. , Bruns Tim M. 
Published: October 2023

AbstractMicroelectrodes serve as a fundamental tool in electrophysiology research throughout the nervous system, providing a means of exploring neural function with a high resolution of neural firing information. We constructed a hybrid computational model using the finite element method and multi-compartment cable models to explore factors that contribute to extracellular voltage waveforms that are produced by sensory pseudounipolar neurons — specifically, smaller A-type neurons — and that are recorded by microelectrodes in dorsal root ganglia. The finite element method model included a dorsal root ganglion, surrounding tissues, and a planar microelectrode array. We built a multi-compartment neuron model with multiple trajectories of the glomerular initial segment found in many A-type sensory neurons. Our model replicated both the somatic intracellular voltage profile of Aδ low-threshold mechanoreceptor neurons and the unique extracellular voltage waveform shapes that are observed in experimental settings. Results from this model indicated that tortuous glomerular initial segment geometries can introduce distinct multiphasic properties into a neuron’s recorded waveform. Our model also demonstrated how recording location relative to specific microanatomical components of these neurons, and recording distance from these components, can contribute to additional changes in the multiphasic characteristics and peak-to-peak voltage amplitude of the waveform. This knowledge may provide context for research employing microelectrode recordings of pseudounipolar neurons in sensory ganglia, including functional mapping and closed-loop neuromodulation. Further, our simulations gave insight into the neurophysiology of pseudounipolar neurons by demonstrating how the glomerular initial segment aids in increasing the resistance of the stem axon and mitigating rebounding somatic action potentials.
Cryo-EM structure of the CDK2-cyclin A-CDC25A Complex
Authors: Rowland Rhianna J. , Korolchuk Svitlana , Salamina Marco , Ault James R. , Hart Sam , Turkenburg Johan P. , Blaza James N. , Noble Martin E.M. , Endicott Jane A. 
Published: October 2023

AbstractThe cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich motif of cyclin-dependent protein kinases (CDKs) to activate CDK activity. Here, we present the cryogenic-electron microscopy (cryo-EM) structure of CDK2-cyclin A in complex with CDC25A at 2.91 Å resolution, providing a detailed structural analysis of the overall complex architecture and key protein-protein interactions that underpin this 86 kDa complex. We further reveal an unanticipated CDC25A C-terminal helix that is critical for complex formation. Sequence conservation analysis suggests CDK1/2-cyclin A, CDK1-cyclin B and CDK2/3-cyclin E are suitable binding partners for CDC25A, whilst CDK4/6-cyclin D complexes appear unlikely substrates. A comparative structural analysis of CDK-containing complexes also confirms the functional importance of the conserved CDK1/2 GDSEID motif. This structure improves our understanding of the roles of CDC25 phosphatases in CDK regulation and may inform the development of CDC25- targeting anticancer strategies.
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler’s virus infection-induced acute seizures
Authors: Zierath Dannielle K. , Davidson Stephanie , Manoukian Jonathan , White H. Steve , Meeker Stacey , Ericsson Aaron , Barker-Haliski Melissa 
Published: October 2023

AbstractObjectiveCentral nervous system infection with Theiler’s murine encephalomyelitis virus (TMEV) in C57BL/6J mice can model acquired epileptogenesis. Diet alters the acute seizure incidence in TMEV-infected mice; yet it is unclear whether intestinal dysbiosis may also impact acute or chronic behavioral comorbidities. This study thus assessed the impact of diet sterilization in a specific pathogen-free vivarium on acute seizure presentation, the composition of the gut microbiome, and chronic behavioral comorbidities of epilepsy.MethodsBaseline fecal samples were collected from male C57BL/6J mice (4-5 weeks-old; Jackson Labs) upon arrival. Mice were randomized to either autoclaved (AC) or irradiated (IR) diet (Prolab RMH 3000 – UU diets) or IR (Picolab 5053 – UW IR diet). Mice then underwent intracerebral TMEV or PBS injection three days later. Fecal samples were collected from a subset of mice at infection (Day 0) and Day 7 post-infection. Epilepsy-related working memory deficits and seizure threshold were assessed 6 weeks post-infection. Gut microbiome diversity was determined by 16S rRNA amplicon sequencing of fecal samples.ResultsTMEV-infected mice displayed acute handling-induced seizures, regardless of diet: 28/57 UW IR (49.1%), 30/41 UU IR (73.2%), and 47/77 UU AC (61%) mice displayed seizures. The number of observed seizures significantly differed: UW IR mice had 2.2±2.8 seizures (mean±standard deviation), UU IR mice had 3.5±2.9 seizures, and UU AC mice had 4.4±3.8 seizures during the 7-day monitoring period. The composition of the gut microbiome significantly differed in TMEV-infected mice fed the UU AC diet, with most measured differences occurring in Gram-positive bacteria. TMEV-infected mice fed the UU AC diet displayed worsened chronic working memory.SignificanceIntestinal dysbiosis evokes stark differences in acute seizure presentation in the TMEV model and vastly influences the trajectory of post-TMEV infection-induced behavioral comorbidities of epilepsy. Our study reveals a novel disease-modifying contribution of intestinal bacterial species after TMEV-induced acute seizures.
Innovation in the tourism sector, organizational learning and performance
Authors: Galarza Iván Santiago , León-Carlosama Rocío Guadalupe , Cevallos-Pineda Alba Grisela , Martínez-Gómez Mónica 
Published: October 2023

PurposeThe purpose of this research paper is to establish the impact of process and service innovation on non-financial and financial performance in the tourism sector, as well as to explain the mediating role of organizational learning.Design/methodology/approachA quantitative approach was used, based on partial least squares–structural equation modeling (PLS-SEM), Smart PLS 4.0 software. The sample consisted of 426 establishments in the tourism sector in Zone I, Ecuador. Online surveys were employed to collect data, yielding 118 responses, to assess the impact of innovation on business performance from 2020 to 2022.FindingsProcess and service innovation positively and significantly affect non-financial and financial performance, respectively. Organizational learning mediates the relationship between process innovation and disservice. The relationship between non-financial and financial performance could not be confirmed. The model explains 53.10% of non-financial performance and 26.10% of financial performance.Originality/valueThe relationship between innovation and performance in the tourism sector has been studied in several developed economies, while little has been studied in developing countries. This work contributes to an empirical discussion including a mediating variable in the innovation–performance relationship in the Latin American context.
Crowding-based multi-objective artificial gorilla troops optimizer for brushless direct current motor design optimization
Authors: Bensoltane Hadjaissa , Belli Zoubida 
Published: October 2023

Purpose
This paper aims to present a novel multi-objective version of the Gorilla Troops optimizer (GTO), based on crowding distance, to achieve the optimal design of a brushless direct current motor.

Design/methodology/approach
In the proposed algorithm, the crowding distance technique was integrated into the GTO to perform the leader selection and also for the external archive refinement from extra non-dominated solutions. Furthermore, with a view to improving the diversity of non-dominated solutions in the external archive, mutation operator was used. For constrained problems, an efficient strategy was adopted. The proposed algorithm is referred to as CD-MOGTO.

Findings
To validate the effectiveness of the proposed approach, it was initially tested on three constrained multi-objective problems; thereafter, it was applied to optimize the design variables of brushless direct current motor to concurrently fulfill six inequality constraints, maximize efficiency and minimize total mass.

Originality/value
The results revealed the high potential of the proposed algorithm over different recognized algorithms in solving constrained multi-objective issues and the brushless direct current motors.
Why is a modest gentleman cruel and ruthless? A study on the dark side effect of humble leadership – from the perspective of low-status compensation theory
Authors: Chen Hao , Jiang Jianming , Wang Liang , Zhang Zihan , Bao Jiaying 
Published: October 2023

Purpose
The purpose of this study is to reveal the mechanism of humble leadership inducing abusive supervision from the low-status compensation perspective, examining the mediation role of leader perceived thread to status. Besides, the moderation effect of regulatory focus on the mediation path is discussed.

Design/methodology/approach
This study conducted a three-wave longitudinal survey. The data was collected from 438 leaders and their employees in five Chinese enterprises. This study used Mplus 7.4 and adopted a bootstrapping technique for data analysis.

Findings
Humble leadership has a positive effect on leader perceived threat to status. Leader perceived threat to status plays a mediation role between humble leadership and leader abusive supervision. Leader regulatory focus is the “gate valve” that humble leadership fosters leader abusive supervision. That is, when the leader promotion focus is high, leader perceived threat to status bred by humble leadership is low, resulting in less abusive supervision. When the leader prevention focus is high, humble leadership brings relatively more abusive supervision through perceived threat to status.

Originality/value
This study explores why humble leadership breeds abusive supervision behaviors and reveals the mechanism behind the negative effect of humble leadership based on low-status compensation theory. This study not only promotes the continuous development of the field of humble leadership research through empirical research but also provides guidance for effectively suppressing the negative effects of humble leadership, promoting strengths and avoiding weaknesses and suppressing inappropriate management behaviors in management practice.
The dynamic effect of public debt on economic growth in the era of Macroprudential policy regime: a Bayesian approach
Authors: Ngcobo Thembeka Sibahle , Zungu Lindokuhle Talent , Nkomo Nomusa Yolanda 
Published: October 2023

Purpose
This study aims to test the dynamic impact of public debt and economic growth on newly democratized African countries (South Africa and Namibia) and compare the findings with those of newly democratized European countries (Germany and Ukraine) during the period 1990–2022.

Design/methodology/approach
The methodology involves three stages: identifying the appropriate transition variable, assessing the linearity between public debt and economic growth and selecting the order m of the transition function. The linearity test helps identify the nature of relationships between public debt and economic growth. The wild cluster bootstrap-Lagrange Multiplier test is used to evaluate the model’s appropriateness. All these tests would be executed using the Lagrange Multiplier type of test.

Findings
The results signify the policy switch, as the authors find that the relationship between public debt and economic growth is characterized by two transitions that symbolize that the current stage of the relationship is beyond the U-shape; however, an S-shape. The results show that for newly democratized African countries, the threshold during the first waves was 50% of GDP, represented by a U-shape, which then transits to an inverted U-shape with a threshold of 65% of GDP. Then, for the European case, it was 60% of GDP, which is now 72% of GDP.

Originality/value
The findings suggest that an escalating level of public debt has a negative impact on economic growth; therefore, it is important to implement fiscal discipline, prioritize government spending and reduce reliance on debt financing. This can be achieved by focusing on revenue generation, implementing effective taxation policies, reducing wasteful expenditures and promoting investment and productivity-enhancing measures.
Curating pasts: musealization and tourism in Chinese cities
Authors: Luo Wenhong , Graburn Nelson 
Published: October 2023

Purpose
China has been going through a “museum boom” paralleling the domestic tourism boom since 2000; such growth changed the cultural landscape; museums became a vital characteristic of some Chinese cities for both residents and tourists. Encouraged by this growth, the more ambitious “All-for-one Museum (全域博物馆)” was proposed. The physical boundary between museums and living spaces is infinite ambiguity, challenging the idea of museums as “heterotopias.” This study aims to explore the musealization of urban spaces in the context of anthropology and museology, scrutinizing the cultural-political intentions and meanings of these developments, and seeks to ignite further investigation into the reconstruction of historical imaginaries for tourists and urban populations across related disciplines.

Design/methodology/approach
This paper examines two cases in Chinese metropolises, Beijing and Shanghai, to illustrate this development of musealization, that is, how the cities actively leverage museological values and methods to connect with their past. In the Beijing case, the authors explore how the local government is leading the effort to musealize the city; in the Shanghai case, they will see how tourists, especially dweller-tourists, navigate through a curated past story in the city and connect their own experience, memory and identity with the place.

Findings
The all-for-one museum creates a museal layer projected onto the bigger urban space, even though the authenticity of the “past” is challenged by the modernization development of the city. The authors also find out that for some tourists (especially dweller-tourists), an existential sense of authenticity plays a more significant role as they not only seek to sightsee the past of the city but also to take part in its creation.

Originality/value
This paper discusses two kinds of musealization in cosmopolitan cities of Beijing and Shanghai: top-down and bottom-up. It approaches questions about the musealization of urban spaces from the perspectives of anthropology and museology, and discusses musealization in the specific historical context of China’s modernization process.
The effect of wine tourism on the sustainable performance of Spanish wineries: a structural equation model analysis
Authors: Martínez-Falcó Javier , Marco-Lajara Bartolomé , Zaragoza-Sáez Patrocinio , Sánchez-García Eduardo 
Published: October 2023

PurposeThe purpose of this study is to analyze the effect of wine tourism on the economic, social and environmental performance, i.e. the sustainable performance, of Spanish wineries. In addition, age, size and membership in the protected designation of origin are introduced as control variables to increase the precision of the cause-effect relationships analyzed.Design/methodology/approachA conceptual model is proposed, which is tested by means of structural equation modeling based on data from a survey of 202 Spanish wineries.FindingsThe results indicate the existence of a positive and significant link between wine tourism activities and the three performance typologies analyzed in the Spanish wine context.Originality/valueThe study contributes to the academic literature on wine tourism in a remarkable way, as, to the best of the authors’ knowledge, there is no previous literature that has addressed the effect of wine tourism on the sustainable performance of Spanish wineries, making the study useful for both academics and wine professionals who are considering the implementation or development of this typology of tourism in their facilities.
Juror decision-making within domestic sex trafficking cases: do pre-trial attitudes, gender, culture and right-wing authoritarianism predict believability assessments?
Authors: Stevens Kay Lynn , Mojtahedi Dara , Austin Adam 
Published: October 2023

Purpose
This study aims to examine whether country of residence, sex trafficking attitudes, complainant gender, juror gender and right-wing authoritarianism (RWA) influenced juror decision-making within a sex trafficking case.

Design/methodology/approach
Jury-eligible participants from the USA and the UK participated in an online juror experiment in which an independent group design was used to manipulate the complainant’s gender. Participants completed the juror decision scale, the sex trafficking attitudes scale and the RWA scale.

Findings
Sex trafficking attitudes predicted the believability of both the defendant and complainant. Greater negative beliefs about victims predicted greater defendant believability and lower complainant believability. US jurors reported greater believability of both the complainant and defendant, and RWA was associated with greater defendant believability. However, none of the other factors, including complainant and juror gender, predicted participants’ verdicts. The findings suggest juror verdicts in sex trafficking cases may be less influenced by extra-legal factors, although further research is needed, especially with a more ambiguous case.

Originality/value
This is one of the few cross-cultural comparison studies in the area of jury decision-making, specifically regarding sex trafficking cases. The findings indicated that US participants held more problematic attitudes about sex trafficking than their UK counterparts, although all participants held problematic attitudes about sex trafficking. However, those attitudes did not affect verdict formation about either a male or female complainant. Participants who were more knowledgeable about sex trafficking reported greater complainant believability, suggesting that educational interventions may provide greater support for victims in court.
Determinants, processes, and impacts of indigenous entrepreneurship: a systematic literature review
Authors: AlMehrzi Aaesha Ahmed , Tipu Syed Awais , Sarker Abu Elias 
Published: October 2023

Purpose
This paper aims to provide a systematic review of the academic literature on the determinants, processes and impacts of indigenous entrepreneurship (IE), highlights its contribution to current knowledge and identifies research gaps to guide future research.

Design/methodology/approach
Databases used in this study included Scopus, ABI, Business Source Complete, ProQuest and Emerald Insight. In total, 84 articles were included in the review.

Findings
The findings revealed that 33 studies were qualitative, 12 used a survey-based approach, 25 were conceptual and 14 used mixed approaches. The focus on theory-building research underlines the fact that more theory-testing research is needed in the future. In total, 38 studies were conducted in developed countries and 43 in developing countries. The findings indicated that IE was driven by many determinants such as family and clan ties, patriarchy and social stratification, government support and conducive entrepreneurial ecosystems. Processes related to policies, IE development programs, partnerships, expenditure mechanisms, equitable distribution of benefits and resource mobilization. The outcomes of IE included economic development, sustainability, increased indigenous economic participation, enhanced quality of life, self-determination and preserving cultural heritage.

Research limitations/implications
The current paper has some limitations. Firstly, it focuses only on academic journals and excludes conferences, books and working papers. Secondly, it includes only English language academic articles. However, while the current systematic literature review (SLR) has these limitations, it presents a thorough view of the determinants, processes and impacts of IE. Future studies may consider other sources beyond academic journals and also include non-English publications, and this approach may identify interesting areas for future research.

Originality/value
Existing reviews of IE take a narrow perspective and fail to present a comprehensive view of the IE phenomenon. The current study aims to fill this gap in the literature and provides a SLR pertaining to IE’s determinants, processes and impacts. The review is both timely and relevant because it identifies gaps and serves as a springboard to guide future research.