bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of 2009 American Recovery and Reinvestment Act (ARRA) health center investments on disadvantaged neighborhoods after recession
Authors: Tung Elizabeth L. , Asfour Nour , Bolton Joshua D. , Huang Elbert S. , Zhang Calvin , Anselin Luc 
Published: January 2024

Abstract
Background
Federally qualified health centers (FQHCs) are integral to the U.S. healthcare safety net and uniquely situated in disadvantaged neighborhoods. The 2009 American Recovery and Reinvestment Act (ARRA) invested $2 billion in FQHC stimulus during the Great Recession; but it remains unknown whether this investment was associated with extended benefits for disadvantaged neighborhoods.

Methods
We used a propensity-score matched longitudinal design (2008–2012) to examine whether the 2009 ARRA FQHC investment was associated with local jobs and establishments recovery in FQHC neighborhoods. Job change data were obtained from the Longitudinal Employer-Household Dynamics (LEHD) survey and calculated as an annual rate per 1,000 population. Establishment change data were obtained from the National Neighborhood Data Archive (NaNDA) and calculated as an annual rate per 10,000 population. Establishment data included 4 establishment types: healthcare services, eating/drinking places, retail establishments, and grocery stores. Fixed effects were used to compare annual rates of jobs and establishments recovery between ARRA-funded FQHC census tracts and a matched control group.

Results
Of 50,381 tracts, 2,223 contained ≥ 1 FQHC that received ARRA funding. A higher proportion of FQHC tracts had an extreme poverty designation (11.6% vs. 5.4%), high unemployment rate (45.4% vs. 30.3%), and > 50% minority racial/ethnic composition (48.1% vs. 36.3%). On average, jobs grew at an annual rate of 3.84 jobs per 1,000 population (95% CI: 3.62,4.06). In propensity-score weighted models, jobs in ARRA-funded tracts grew at a higher annual rate of 4.34 per 1,000 (95% CI: 2.56,6.12) relative to those with similar social vulnerability. We observed persistent decline in non-healthcare establishments (-1.35 per 10,000; 95% CI: -1.68,-1.02); but did not observe decline in healthcare establishments.

Conclusions
Direct funding to HCs may be an effective strategy to support healthcare establishments and some jobs recovery in disadvantaged neighborhoods during recession, reinforcing the important multidimensional roles HCs play in these communities. However, HCs may benefit from additional investments that target upstream determinants of health to mitigate uneven recovery and neighborhood decline.
Implications of Patient-Reported Outcome Measures among patients with recently diagnosed type 2 diabetes
Authors: Abdel-Rahman Nura , Manor Orly , Elran Einat , Siscovick David , Calderon-Margalit Ronit 
Published: January 2024

Abstract
Background
For the past two decades, the assessment of the quality of diabetes care has mostly relied on clinical quality indicators. These have not included Patient-Reported Outcome Measures (PROMs) which provide information on outcomes deemed valuable by patients. We aimed to examine the potential utility of PROMs in type 2 diabetes care and to study the association of PROMs with patients' characteristics and clinical quality indicators.

Methods
A cross-sectional survey of recently (≤ 4 years) diagnosed patients with type 2 diabetes (n = 392) in the setting of a large health plan. PROMs were based on two well-validated questionnaires, the Problem Areas in Diabetes (PAID) one-page questionnaire that measures diabetes-related distress, and the ten item PROMIS-10 global health questionnaire that measures general health. Additional items were added following a previous qualitative study among Israeli patients with diabetes. The survey was carried out using phone interviews, and data collected were linked to the electronic medical records. Multivariable regression models were used to assess the associations of socio-demographic variables and clinical quality indicators with the PROMs.

Results
About a fifth of participants (22%) had high diabetes-related distress (PAID score ≥ 40), a third reported that they did not feel confident in self-management of diabetes and about a third reported having sexual dysfunction. Women, younger patients, and those with a low education level (≤ 12 years) reported worse general health, were more likely to experience high diabetes-related distress, and to have low confidence in diabetes self-management. Interestingly, performance of all seven diabetes quality indicators was associated with worse general health and high diabetes-related distress. Of note, levels of glycated hemoglobin, LDL-cholesterol, or blood pressure were not associated with PROMs.

Conclusions
PROMs provide important information on patient self-reported health status and are likely to reflect aspects of the quality of care that are not otherwise available to clinicians. Thus, the use of PROMs has the potential to expand the evaluation of diabetes care and promote patient-centered care. We recommend that policy-makers in the Ministry of Health and health maintenance organizations implement PROMs for assessing and improving the care for patients with type 2 diabetes.
Screening for depression in children and adolescents in primary care or non-mental health settings: a systematic review update
Authors: Beck Andrew , Dryburgh Nicole , Bennett Alexandria , Shaver Nicole , Esmaeilisaraji Leila , Skidmore Becky , Patten Scott , Bragg Heather , Colman Ian , Goldfield Gary S. , Nicholls Stuart Gordon , Pajer Kathleen , Meeder Robert , Vasa Priya , Shea Beverley J. , Brouwers Melissa , Little Julian , Moher David 
Published: January 2024

Abstract
Background
The transition from childhood to adolescence is associated with an increase in rates of some psychiatric disorders, including major depressive disorder, a debilitating mood disorder. The aim of this systematic review is to update the evidence on the benefits and harms of screening for depression in primary care and non-mental health clinic settings among children and adolescents.

Methods
This review is an update of a previous systematic review, for which the last search was conducted in 2017. We searched Ovid MEDLINE® ALL, Embase Classic+Embase, PsycINFO, Cochrane Central Register of Controlled Trials, and CINAHL on November 4, 2019, and updated on February 19, 2021. If no randomized controlled trials were found, we planned to conduct an additional search for non-randomized trials with a comparator group. For non-randomized trials, we applied a non-randomized controlled trial filter and searched the same databases except for Cochrane Central Register of Controlled Trials from January 2015 to February 2021. We also conducted a targeted search of the gray literature for unpublished documents. Title and abstract, and full-text screening were completed independently by pairs of reviewers.

Results
In this review update, we were unable to find any randomized controlled studies that satisfied our eligibility criteria and evaluated the potential benefits and harms of screening for depression in children and adolescents. Additionally, a search for non-randomized trials yielded no studies that met the inclusion criteria.

Conclusions
The findings of this review indicate a lack of available evidence regarding the potential benefits and harms of screening for depression in children and adolescents. This absence of evidence emphasizes the necessity for well-conducted clinical trials to evaluate the effectiveness of depression screening among children and adolescents in primary care and non-mental health clinic settings.

Systematic review registration
PROSPERO CRD42020150373.
Clinically relevant sequence types of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae detected in Finnish wastewater in 2021–2022
Authors: Heljanko Viivi , Tyni Olga , Johansson Venla , Virtanen Jussa-Pekka , Räisänen Kati , Lehto Kirsi-Maarit , Lipponen Anssi , Oikarinen Sami , Pitkänen Tarja ,   WastPan Study Group, Al-Mustapha Ahmad , Kurittu Paula , Länsivaara Annika , Hyder Rafiqul , Janhonen Erja , Tiwari Ananda , Hokajärvi Anna-Maria , Kolehmainen Aleksi , Möttönen Teemu , Luomala Oskari , Juutinen Aapo , Blomqvist Soile , Savolainen-Kopra Carita , Sarekoski Anniina , Heikinheimo Annamari 
Published: January 2024

Abstract
Background
Antimicrobial resistance (AMR) is a critical threat to human health. Escherichia coli and Klebsiella pneumoniae are clinically the most important species associated with AMR and are the most common carbapenemase-producing (CP) Enterobacterales detected in human specimens in Finland. Wastewater surveillance has emerged as a potential approach for population-level surveillance of AMR, as wastewater could offer a reflection from a larger population with one sample and minimal recognized ethical issues. In this study, we investigated the potential of wastewater surveillance to detect CP E. coli and K. pneumoniae strains similar to those detected in human specimens.

Methods
Altogether, 89 composite samples of untreated community wastewater were collected from 10 wastewater treatment plants across Finland in 2021–2022. CP E. coli and K. pneumoniae were isolated using selective culture media and identified using MALDI-TOF MS. Antimicrobial susceptibility testing was performed using disk diffusion test and broth microdilution method, and a subset of isolates was characterized using whole-genome sequencing.

Results
CP E. coli was detected in 26 (29.2%) and K. pneumoniae in 25 (28.1%) samples. Among E. coli, the most common sequence type (ST) was ST410 (n = 7/26, 26.9%), while ST359 (n = 4/25, 16.0%) predominated among K. pneumoniae. Globally successful STs were detected in both E. coli (ST410, ST1284, ST167, and ST405) and K. pneumoniae (ST512, ST101, and ST307). K. pneumoniae carbapenemases (KPC) were the most common carbapenemases in both E. coli (n = 11/26, 42.3%) and K. pneumoniae (n = 13/25, 52.0%), yet also other carbapenemases, such as blaNDM-5,blaOXA-48, and blaOXA-181, were detected. We detected isolates harboring similar ST and enzyme type combinations previously linked to clusters in Finland, such as E. coli ST410 with blaKPC-2 and K. pneumoniae ST512 with blaKPC-3.

Conclusions
Our study highlights the presence of clinically relevant strains of CP E. coli and K. pneumoniae in community wastewater. The results indicate that wastewater surveillance could serve as a monitoring tool for CP Enterobacterales. However, the specificity and sensitivity of the methods should be improved, and technologies, like advanced sequencing methods, should be utilized to distinguish data with public health relevance, harness the full potential of wastewater surveillance, and implement the data in public health surveillance.
Analysis of microbial diversity and its degradation function in wooden piles at Shahe ancient bridge site in Xi’an and protection measures
Authors: Cao Jing , Liu Xin , Wang Juanli , Chen Hua , Liu Dan , Li Jin , Mai Bingjie 
Published: January 2024

Abstract
Microorganisms possess the capability to impact virtually any form of cultural heritage, leading to contamination, degradation, and even combined degradation, where diverse microorganism communities facilitate the decay of wooden materials. This study aims to analyze the microbial diversity of the wooden structure bridge at the Shahe Ancient bridge site in Xi'an. The objective is to investigate the correlation between microbial species and the state of wood degradation, as well as explore the relationship between wood microbial species and the potential influence of the wood preservation environment on its long-term preservation. Simultaneously, the conventional laboratory separation technique was employed to isolate the microorganisms that were contaminated by experimental ancient wood. This was done to assess the inhibitory effect of two fungicides on the dominant microorganisms found in ancient wood, identify the most effective inhibitor, and subsequently establish an experimental foundation for safeguarding ancient bridge wood structures. The primary objective of this research was to establish microbial control criteria for the enduring conservation of historical sites, while also equipping conservators with scientifically-guided data to inform future research and restoration endeavors.

Graphical Abstract
Risk of surface movements and reservoir deformation for high-temperature aquifer thermal energy storage (HT-ATES)
Authors: Stricker Kai , Egert Robert , Schill Eva , Kohl Thomas 
Published: January 2024

AbstractHigh-temperature aquifer thermal energy storage (HT-ATES) systems are designed for seasonal storage of large amounts of thermal energy to meet the demand of industrial processes or district heating systems at high temperatures (> 100 °C). The resulting high injection temperatures or pressures induce thermo- and poroelastic stress changes around the injection well. This study estimates the impact of stress changes in the reservoir on ground surface deformation and evaluates the corresponding risk. Using a simplified coupled thermo-hydraulic-mechanical (THM) model of the planned DeepStor demonstrator in the depleted Leopoldshafen oil field (Upper Rhine Graben, Germany), we show that reservoir heating is associated with stress changes of up to 6 MPa, which can cause vertical displacements at reservoir depth in the order of 10–3 m in the immediate vicinity of the hot injection well. Both the stress changes and the resulting displacements in the reservoir are dominated by thermoelasticity, which is responsible for up to 90% of the latter. Uplift at the surface, on the contrary, is primarily controlled by poroelasticity with by two orders of magnitude attenuated displacements of << 10–3 m. Our calculations further show that the reservoir depth, elastic modulus, and injection/production rates are the dominant controlling parameters for the uplift, showing variations of up to two order of magnitudes between shallower reservoirs with low elastic moduli and deeper and more competent reservoirs. In addition, our findings demonstrate that the cyclic operation of HT-ATES systems reduces the potential for uplift compared to the continuous injection and production of conventional geothermal doublets, hydrocarbon production, or CO2 storage. Consequently, at realistic production and injection rates and targeting reservoirs at depths of at least several hundred meters, the risk of ground surface movement associated with HT-ATES operations in depleted oil fields in, e.g., the Upper Rhine Graben is negligible.
Understanding the pathophysiology of acute critical illness: translational lessons from zebrafish models
Authors: Fujii Kensuke , Yamakawa Kazuma , Takeda Yuriko , Okuda Natsuko , Takasu Akira , Ono Fumihito 
Published: January 2024

AbstractThe models used to investigate the pathophysiological mechanisms of acute critical illness are not limited to mammalian species. The zebrafish (Danio rerio) is a popular model organism for studying diseases due to its transparency and rapid development. The genes and signaling pathways involved in acute critical illness appear highly conserved among zebrafish and humans. Forward genetics such as random mutagenesis by a chemical mutagen or reverse genetics methods represented by CRISPR/Cas9 allowed researchers to reveal multiple novel aspects of pathological processes in areas including infection, immunity, and regeneration. As a model of sepsis, transgenic zebrafish allowed the visualization of lipopolysaccharide (LPS)-induced vascular leakage in vivo and the demonstration of changes in the expression of cellular junction proteins. Other transgenic zebrafish visualizing the extravascular migration of neutrophils and macrophages have demonstrated a decrease in neutrophil numbers and an increased expression of an inflammatory gene, which replicates a phenomenon observed in humans in clinically encountered sepsis. The regenerative potential and the visibility of zebrafish organs also enabled clarification of important mechanisms in wound healing, angiogenesis, and neurogenesis. After spinal cord injury (SCI), a marker gene expressed in glial bridging was discovered. Furthermore, localized epithelial-to-mesenchymal transition (EMT) and molecular mechanisms leading to spinal cord repair were revealed. These translational studies using zebrafish show the potential of the model system for the treatment of acute critical illnesses such as sepsis, organ failure, and trauma.
The rise and fall of cryptocurrencies: defining the economic and social values of blockchain technologies, assessing the opportunities, and defining the financial and cybersecurity risks of the Metaverse
Authors: Radanliev Petar 
Published: January 2024

AbstractThis study examines blockchain technologies and their pivotal role in the evolving Metaverse, shedding light on topics such as how to invest in cryptocurrency, the mechanics behind crypto mining, and strategies to effectively buy and trade cryptocurrencies. While it contextualises the common queries of "why is crypto crashing?" and "why is crypto down?", the research transcends beyond the frequent market fluctuations to unravel how cryptocurrencies fundamentally work and the step-by-step process on how to create a cryptocurrency. Contrasting existing literature, this comprehensive investigation encompasses both the economic and cybersecurity risks inherent in the blockchain and fintech spheres. Through an interdisciplinary approach, the research transitions from the fundamental principles of fintech investment strategies to the overarching implications of blockchain within the Metaverse. Alongside exploring machine learning potentials in financial sectors and risk assessment methodologies, the study critically assesses whether developed or developing nations are poised to reap greater benefits from these technologies. Moreover, it probes into both enduring and dubious crypto projects, drawing a distinct line between genuine blockchain applications and Ponzi-like schemes. The conclusion resolutely affirms the staying power of blockchain technologies, underlined by a profound exploration of their intrinsic value and a reflective commentary by the author on the potential risks confronting individual investors.
Validation of the Patient-Reported Outcomes Measurement Information System (PROMIS®) physical function questionnaire in late-onset Pompe disease using PROPEL phase 3 data
Authors: Kishnani Priya S. , Shohet Simon , Raza Syed , Hummel Noemi , Castelli Jeffrey P. , Sitaraman Das Sheela , Jiang Heng , Kopiec Agnieszka , Keyzor Ian , Hahn Andreas 
Published: January 2024

Abstract
Background
The construct validity and interpretation of the Patient-Reported Outcome Measurement Information System (PROMIS®) Physical Function short form 20a (PF20a) questionnaire were evaluated for patients with late-onset Pompe disease (LOPD), a rare, autosomal recessive, progressive neuromuscular disorder treatable by enzyme replacement therapy (ERT).

Methods
In the phase 3 PROPEL study, adults with LOPD underwent testing of physical functioning and had PRO measurements at baseline and at weeks 12, 26, 38, and 52 while receiving experimental or standard-of-care ERT. All patients were pooled for analyses, without comparisons between treatment groups. Associations and correlations between PROMIS PF20a scores and the 6-minute walk distance (6MWD), % predicted forced vital capacity (FVC), manual muscle test (MMT) of the lower extremities, Gait, Stairs, Gowers’ maneuver, Chair (GSGC) score, and Rasch-built Pompe-specific Activity (R-PAct) scale were evaluated by calculating regression coefficients in linear regression models and Pearson correlation coefficients (R); patients’ age, sex, race, ERT prior to study, body mass index, and study treatment were included as covariables. The minimal clinically important difference (MCID) of PROMIS PF20a was determined using distribution- and anchor-based methods.

Results
123 patients received at least 1 dose of ERT. In multivariable analyses, PROMIS PF20a scores had strong correlations with R-PAct scores (R = 0.83 at baseline and R = 0.67 when evaluating changes between baseline and 52 weeks) and moderate correlations with the 6MWD (R = 0.57 at baseline and R = 0.48 when evaluating changes between baseline and 52 weeks). Moderate correlations were also observed between PROMIS PF20a and MMT (R = 0.54), GSGC (R=-0.51), and FVC (R = 0.48) at baseline. In multivariable linear regression models, associations were significant between PROMIS PF20a and 6MWD (P = 0.0006), MMT (P = 0.0034), GSGC (P = 0.0278), and R-PAct (P < 0.0001) at baseline, between PROMIS PF20a and 6MWD (P < 0.0001), FVC (P = 0.0490), and R-PAct (P < 0.0001) when combining all measurements, and between PF20a and 6MWD (P = 0.0016) and R-PAct (P = 0.0001) when evaluating changes in scores between baseline and 52 weeks. The anchor-based and distribution-based MCID for a clinically important improvement for PROMIS PF20a were 2.4 and 4.2, respectively.

Conclusions
PROMIS PF20a has validity as an instrument both to measure and to longitudinally follow physical function in patients with LOPD.

Trial registration
ClinicalTrials.gov, NCT03729362. Registered 2 November 2018, https://www.clinicaltrials.gov/search?term=NCT03729362.
A qualitative study of daily activities that inform a process-based model of well-being among Singaporean adults
Authors: Hashim Jumana , Yi Huso , Foong Pin Sym , Tai E Shyong , Nolan Robert P 
Published: January 2024

Abstract
Background
Individual appraisals of personal well-being consider a spectrum of constructs including the reflections on the degree to which one’s life is ultimately secure, meaningful, or valued in the context of dynamic changes in their bio-psycho-social environments. Standardized questionnaires for well-being evaluate an ideal state of health which is operationally defined by abstract constructs. Patient reports describe well-being as a more dynamic construct that relates to how they adapt to successive changes in their life situations. While response shift theory addresses this dynamic nature, little is known about how personal well-being is pursued as personal aspirations evolve. In this study, we identify regularly practiced goal-directed activities reported to contribute to the pursuit of personal well-being. We then propose a taxonomy of these reported activities to inform a process-based model for well-being.

Methods
Purposive sampling was conducted with individuals, 30 to 60 years of age, with diverse ethnicities reflecting the Singaporean population. Individual semi-structured interviews were administered with the primary question: “What are the things or activities you have done in the last two weeks that made you feel like you had a good day?” Probes explored the personally salient meaning of each activity. A thematic approach was used for data analysis followed by a framework analysis to categorize the activities into major themes.

Results
We interviewed 40 individuals comprised of 60% female participants. Thematic analysis identified eight types of goal-directed activities, which were categorized under three major themes: (i) Self-Affirming Care through individual self-care and maintaining interpersonal relationships, (ii) Achievement-Focused Tasks as indicated by work-related accomplishments and developing a skill or hobby, (iii) Affiliative Growth and Support as reflected through religious practices and community services. Planned physical activity contributed to self-affirming care and achievement-focused tasks. Social affirming roles were associated with both achievement-focused tasks and affiliative growth and support.

Conclusions
In the dimensions of goal-directed activities identified, there is close alignment between Self-Affirming Care and attachment theory; Achievement-Focused Tasks and self-determination theory; and Affiliative Growth and Support and social mattering. These findings can contribute to a comprehensive process-based model of well-being which is more closely aligned to patient-report appraisals of personal well-being.