bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Persistent Intramolecular C‐H⋅⋅⋅X(N,O) Bonds in Solid State and Solution
Authors: Cappelli Andrea , Giorgi Gianluca , Anzini Maurizio , Vomero Salvatore , Ristori Sandra , Rossi Claudio , Donati Alessandro 
Published: April 2004

AbstractThe formation of intramolecular CH⋅⋅⋅X(N,O) bonds and their persistence in solution were studied by X‐ray crystallography and NMR techniques in two different rotamers of a molecule containing the ortho‐carborane cage, an amide group and a quinoline ring. Experimental data were confirmed by theoretical ab initio calculations. From the resolved structure of the two forms of this potentially active drug for boron neutron capture therapy, accurate bonding and geometric parameters were extracted for this non‐classic hydrogen interaction, and their strength was calculated. These findings provided new insight in the theory of CH⋅⋅⋅X bonds, which appear stronger and less rare than it was previously thought.
Supramolecular Complexation of Alkali Cations through Mechanochemical Reactions between Crystalline Solids
Authors: Braga Dario , Maini Lucia , Giaffreda Stefano L. , Grepioni Fabrizia , Chierotti Michele R. , Gobetto Roberto 
Published: April 2004

AbstractThe organometallic zwitterion [CoIII(η5‐C5H4COOH)(η5‐C5H4COO)] reacts quantitatively as a solid polycrystalline phase with a number of crystalline alkali salts MX (M = K+, Rb+, Cs+, NH4+; X = Cl−, Br−, I−, PF6−, although not in all cation/anion permutations) to afford supramolecular complexes of the formula [CoIII(η5‐C5H4COOH)(η5‐C5H4COO)]2⋅M+X−. In some cases, the mechanochemical complexation requires kneading of the two solids with a catalytic amount of water. The characterization of the solid‐state products has been achieved by a combination of X‐ray single‐crystal and powder‐diffraction experiments. The hydrogen‐bonding interactions have been investigated by solid‐state NMR spectroscopy. The mechanochemical reactions imply a profound solid‐state rearrangement accompanied by breaking and forming of OH⋅⋅⋅O hydrogen‐bonding interactions between the organometallic molecules. All compounds could also be obtained by solution crystallization of the inorganic salts in the presence of the organometallic unit. The solid‐state complexation of alkali cations by the organometallic zwitterion has been described as a special kind of solvation process taking place in the solid state.
[Ind2TiMe2]: A General Catalyst for the Intermolecular Hydroamination of Alkynes
Authors: Heutling Andreas , Pohlki Frauke , Doye Sven 
Published: April 2004

Abstract[Ind2TiMe2] (Ind=indenyl) is a highly active and general catalyst for the intermolecular hydroamination of alkynes. It catalyzes the reaction of primary aryl‐, tert‐alkyl‐, sec‐alkyl‐, and n‐alkylamines with internal and terminal alkynes. In the case of unsymmetrically substituted 1‐phenyl‐2‐alkylalkynes, the reactions occur with modest to excellent regioselectivities, whereby formation of the anti‐Markovnikov regioisomers is favored. While the major product of hydroamination reactions of terminal arylalkynes is always the anti‐Markovnikov isomer, alkylalkynes react with arylamines to preferably give the Markovnikov products. To achieve reasonable rates for the addition of sterically less hindered n‐alkyl‐ and benzylamines to alkynes, these amines must be added slowly to the reaction mixtures. This behavior is explained by the fact that the catalytic cycle proposed on the basis of an initial kinetic investigation includes the possibility that the rate of the reaction increases with decreasing concentration of the employed amine. Furthermore, no dimerization of the catalytically active imido complex is observed in the hydroamination of 1‐phenylpropyne with 4‐methylaniline in the presence of [Ind2TiMe2] as catalyst. In general, a combination of [Ind2TiMe2]‐catalyzed hydroamination of alkynes with subsequent reduction leads to the formation of secondary amines with good to excellent yields. Particularly impressive is that [Ind2TiMe2] makes it possible for the first time to perform the reactions of n‐alkyl‐ and benzylamines with 1‐phenylpropyne in a highly regioselective fashion.
Active Anionic Zero‐Valent Palladium Catalysts: Characterization by Density Functional Calculations
Authors: Kozuch Sebastian , Shaik Sason , Jutand Anny , Amatore Christian 
Published: April 2004

AbstractThis works uses DFT (B3LYP/LACVP*+//B3LYP/LACVP* level) to ascertain the existence of the tricoordinate, anionic zero‐valent palladium complexes that were postulated as the active species in the catalytic cycles of Pd‐catalyzed Heck and cross‐coupling reactions. The variety of complexes studied (1 and 2), include [Pd(PR3)2X]− species, in which R=H, Me, vinyl, and phenyl, and X=Cl, Br, I, AcO, and TFA, as well as bidentate complexes, [Pd{Ph2P(CH2)nPh2P}X]−, in which X=Cl, AcO and n=3–6. The study shows that these complexes exist as distinct minima in the gas phase as well as in THF. In addition, it provides geometric features and PdX− dissociation energies for all these complexes as well as some NMR and IR data, which show a clear distinction in these features between the tri‐ and dicoordinate Pd0 species. An orbital interaction model and perturbation theory arguments account for the bonding mechanism and rationalize all the trends in the stability of the PdX bond. These trends include the effects of variation of X, R, and the length of the linker in the bidentate ligands.
Rational Synthesis of Multicyclic Bis[2]catenanes
Authors: Bogdan Anca , Vysotsky Myroslav O. , Ikai Tomoyuki , Okamoto Yoshio , Böhmer Volker 
Published: April 2004

AbstractBis‐loop tetraurea calix[4]arene 6 has been prepared by acylation of the wide‐rim calix[4]arene tetraamine 1 with the activated bis(urethane) 8 under dilution conditions. Similarly the bis(Boc‐protected) tetraamine 2 is converted into the mono‐loop derivative 3 which after deprotection and acylation gives the bisalkenyl derivative 5. In apolar solvents this tetraurea calix[4]arene 5 forms regioselectively a single hydrogen‐bonded homodimer, from which the bis[2]catenane 10 a is formed in 49 % by a metathesis reaction followed by hydrogenation. Bis‐loop derivative 6 forms no homodimers for steric reasons, but a stoichiometric mixture with the open‐chain tetraalkenyl derivative 7 a contains exclusively the heterodimer. Metathesis and subsequent hydrogenation now yields 65 % of the pure bis[2]catenane 10 a which could not be isolated from the complex reaction mixture obtained from the homodimer 7 a⋅7 a. The chirality of 10 a (D2 symmetry) has been verified by optical resolution using HPLC on a chiral stationary phase.
Comparative Study of LiNi0.5Mn1.5O4‐δ and LiNi0.5Mn1.5O4 Cathodes Having Two Crystallographic Structures: Fd$\bar 3$m and P4332.
Authors: Kim J.‐H. , Myung S.‐T. , Yoon C. S. , Kang S. G. , Sun Y.‐K. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Open‐Framework Zinc Phosphite, Zn3(HPO3)4×Ni(en)2 (H2O)2, Templated by a Transition‐Metal Complex.
Authors: Lin Zhi‐En , Zhang Jie , Zheng Shou‐Tian , Yang Guo‐Yu 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Hydrothermal Synthesis and Characterization of a Novel Sinusoidal Layer Structure Constructed from Polyoxometalates and Coordination Complex Fragments.
Authors: Cui Xiao‐Bing , Xu Ji‐Qing , Li Yong , Sun Ying‐Hua , Yang Guo‐Yu 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Heterogeneous Asymmetric Transfer Hydrogenation of Ketones Using Highly Recyclable and Accessible Silica‐Immobilized Ru‐TsDPEN Catalysts.
Authors: Liu Pei Nian , Gu Pei Ming , Wang Fei , Tu Yong Qiang 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Fluorine‐Containing π‐Allylmetal Complex. The Transition Metal‐Catalyzed Allylic Substitution Reaction of Fluorinated Allyl Mesylates with Various Carbon Nucleophiles.
Authors: Konno Tsutomu , Takehana Tsuyoshi , Ishihara Takashi , Yamanaka Hiroki 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Dehydrogenation and Isomerization of Butane over Cr Catalysts Supported on H‐SSZ‐35 Type Zeolites.
Authors: Inaba Megumu , Murata Kazuhisa , Saito Masahiro , Takahara Isao , Mimura Naoki , Hamada Hideaki , Kurata Yohei 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cyclopropyl Building Blocks in Organic Synthesis. Part 96. Novel Liquid Crystalline Compounds Containing Bicyclo[3.1.0]hexane Core Units.
Authors: Kozhushkov Sergei I. , Langer Rainer , Yufit Dmitrii S. , Howard Judith A. K. , Schill Heiko , Demus Dietrich , Miyazawa Kazutoshi , de Meijere Armin 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diels—Alder Cycloadditions of 3‐Phenylamino‐5‐bromo‐2‐pyrone for the Synthesis of Constrained α‐Amino Acid Derivatives.
Authors: Kim Won‐Suk , Lee Jin‐Hee , Kang Jongmin , Cho Cheon‐Gyu 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Rapid Solid‐State Synthesis of Diazenecarboxamide‐Azo Compounds Using Ferric Nitrate and Sodium Bisulfate as an Oxidation System.
Authors: Xue Wan‐Xin , Li Jian‐Ping , Zhang Xin‐Ying , Wang Yu‐Lu 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Effect of Temperature on the Enantioselectivity in the Oxazaborolidine‐Catalyzed Asymmetric Reduction of Ketones. Noncatalytic Borane Reduction, a Nonneglectable Factor in the Reduction System.
Authors: Xu Jiaxi , Wei Tiezheng , Zhang Qihan 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Convenient Method for Preparing Aromatic α,β‐Unsaturated Ketones from α,β‐Unsaturated Acyl Chlorides and Arylboronic Acids via Suzuki—Miyaura Type Coupling Reaction.
Authors: Urawa Yoshio , Nishiura Katsutoshi , Souda Shigeru , Ogura Katsuyuki 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Unexpected Migration and Oxidative Cyclization of Substituted 2‐Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights.
Authors: Coe Jotham W. , Bianco Krista E. , Boscoe Brian P. , Brooks Paige R. , Cox Eric D. , Vetelino Michael G. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Epoxidation of Terminal Olefins by Oxygen Catalyzed by a Mixture of Manganese and Cobalt Salts of p‐Aminobenzoic Acid Supported on Silica Gel.
Authors: Hashemi Mohammed M. , Khoshabro Daruoosh Keshavarz 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Rhodium‐Catalyzed Carbonylation of Norbornene under Water—Gas‐Shift Reaction Conditions. Selective Formation of Co‐Dimeres with Lactone Terminus.
Authors: Zhou Da‐Yang , Zhang Shi‐Wei , Onitsuka Kiyotaka , Takahashi Shigetoshi 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 1‐(Alkoxycarbonyl)methylene‐1,3‐dihydroisobenzofurans and 4‐(Alkoxycarbonyl)benzo[c]pyrans by Palladium‐Catalyzed Oxidative Carbonylation of 2‐Alkynylbenzyl Alcohols, 2‐Alkynylbenzaldehydes and 2‐Alkynylphenyl Ketones.
Authors: Bacchi Alessia , Costa Mirco , Della Ca Nicola , Fabbricatore Marcella , Fazio Alessia , Gabriele Bartolo , Nasi Cristina , Salerno Giuseppe 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two‐Step Synthesis of β‐Alkyl Chalcones and Their Use in the Synthesis of 3,5‐Diaryl‐5‐alkyl‐4,5‐dihydropyrazoles.
Authors: Cox Christopher D. , Breslin Michael J. , Mariano Brenda J. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Trapping of a Phosphazide Intermediate in the Staudinger Reaction of Tertiary Phosphines with Azides and Its Application to the Synthesis of Analogues of the Marine Alkaloid Midpacamide.
Authors: Fresneda Pilar M. , Castaneda Marta , Sanz Miguel A. , Molina Pedro 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 1,2,4‐Triazolo[3,4‐b]‐1,3,4‐thiadiazole Derivatives Containing Fragments of Sterically‐Hindered Phenol.
Authors: Kelarev V. I. , Gres'ko S. V. , Abu‐Ammar V. M. , Kobrakov K. I. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Expedient Entry to Chroman Derivatives via Indium‐Mediated Intramolecular Allenylation Reactions.
Authors: Kang Han‐Young , Kim Yong‐Tae , Yu Yeon‐Kwon , Cha Joo Hwan , Cho Yong Seo , Koh Hun Yeong 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Herbicidal Activity of (Z)‐Ethoxyethyl 2‐Cyano‐3‐(2‐methylthio‐5‐pyridylmethylamino)acrylates.
Authors: Wang Qing Min , Sun Hui Kai , Huang Run Qiu 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
One‐Pot Synthesis of 3‐(1H‐Imidazo[4,5‐f]quinolin‐2‐yl)‐chromen‐2‐one under Microwave Irradiation.
Authors: Rajitha B. , Rao M. Kanakalingeswara , Reddy P. Narsimha 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bismuth Triflate Catalyzed Condensation of δ‐Hydroxy‐α,β‐Unsaturated Aldehydes with Aryl Amines.
Authors: Yadav J. S. , Reddy B. V. S. , Parimala G. , Raju A. Krishnam 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Formal [6 + 3] Cycloaddition of Fulvenes with 2H‐Azirine: A Facile Approach to the [2]Pyrindines System.
Authors: Hong Bor‐Cherng , Gupta Arun Kumar , Wu Ming‐Fun , Liao Ju‐Hsiou 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Antimicrobial Activity of Amino Acid, Imidazole, and Sulfonamide Derivatives of Pyrazolo[3,4‐d]pyrimidine.
Authors: Ghorab M. M. , Ismail Zeinab H. , Abdel‐Gawad Soad M. , Aziem Anhar Abdel 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Facile Synthesis of 1,2‐Dihydroquinazolin‐4(3H)‐ones with the Aid of a Low‐Valent Titanium Reagent.
Authors: Shi Daqing , Wang Juxian , Rong Liangce , Zhuang Qiya , Tu Shujiang , Hu Hongwen 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 2‐Substituted 3,4‐Dihydroquinazoline Derivatives via Regioselective Addition of a Carbon Nucleophile to a Carbodiimide.
Authors: Lee Bum Hoon , Lee Jae Yeol , Chung Bong Young , Lee Yong Sup 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Simple and Efficient Synthetic Routes to s‐Triazinyl Dithiocarbamate Derivatives: 2,4‐Diarylamino‐6‐[N‐(4′‐ethoxyphenyl)dithiocarbamoyl]‐s‐triazines and 2,4‐Bis‐[N‐(4′‐ethoxyphenyl)dithiocarbamoyl]‐6‐arylamino‐s‐triazines.
Authors: Desai R. M. , Ravat N. R. , Shah V. H. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Optically Active Tetrahydro‐3‐benzazepine‐2‐carboxylic Acid Derivatives via the Ring Expansion Reaction of Isoquinolines and Enzymatic Resolution.
Authors: Koseki Yuji , Ozawa Hidefumi , Kitahara Katsuaki , Kato Ichiro , Sato Hiroto , Fukaya Haruhiko , Nagasaka Tatsuo 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Dehydrogenative Double Silylation of Acetylenes with Bis‐ and Tris(dichlorosilyl)methanes: One‐Step Synthesis of 1,1,3,3‐Tetrachloro‐1,3‐disilacyclopent‐4‐ene Compounds.
Authors: Phan Son Thanh , Lim Weon Cheol , Han Joon Soo , Yoo Bok Ryul , Jung Il Nam 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Convenient and Direct Route to Phosphinoalkynes via Copper‐Catalyzed Cross‐Coupling of Terminal Alkynes with Chlorophosphanes.
Authors: Afanasiev Vladimir V. , Beletskaya Irina P. , Kazankova Marina A. , Efimova Irina V. , Antipin Mikhail U. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Studies on Tellurium‐Containing Heterocycles. Part 21. Reaction of 2‐Benzotelluropyrylium Salts with Organocopper Reagents: Introduction of a Carbon Functional Group at the C‐1 Position of the Telluropyrylium Cation Ring.
Authors: Sashida Haruki , Satoh Hirohito , Ohyanagi Kazuo 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Intramolecular Coupling of Acetylenic Groups of Bis(alkynyl)phosphanes and Silanes Mediated by Benzynezirconocene: A Route to New Mono‐ and Tricyclic Heterocycles.
Authors: Pirio Nadine , Bredeau Stephane , Dupuis Laurence , Schuetz Peter , Donnadieu Bruno , Igau Alain , Majoral Jean‐Pierre , Guillemin Jean‐Claude , Meunier Philippe 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reactivity of 2‐Deoxy‐2‐iodoglycosyl Isothiocyanates with O‐, S‐, and N‐Nucleophiles. Synthesis of Glycopyranoso‐Fused Thiazoles.
Authors: Isac‐Garcia Joaquin , Hernandez‐Mateo Fernando , Calvo‐Flores Francisco G. , Santoyo‐Gonzalez Francisco 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Route to 2′‐O‐Alkyl‐2‐thiouridine Derivatives via 4‐O‐Protection of the Uracil Base and Hybridization Properties of Oligonucleotides Incorporating These Modified Nucleoside Derivatives.
Authors: Okamoto Itaru , Shohda Koh‐ichiroh , Seio Kohji , Sekine Mitsuo 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Thermolytic Carbonates for Potential 5′‐Hydroxyl Protection of Deoxyribonucleosides.
Authors: Chmielewski Marcin K. , Marchan Vicente , Cieslak Jacek , Grajkowski Andrzej , Livengood Victor , Muench Ursula , Wilk Andrzej , Beaucage Serge L. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two New Biocoumarins from Clausena excavata
Authors: Takemura Yuko , Kanao Kinuko , Konoshima Asami , Ju‐ichi Motoharu , Ito Chihiro , Furukawa Hiroshi , Tokuda Harukuni , Nishino Hoyoku 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Facile Preparation, Crystal Structure, and Chemical and Electrochemical Properties of 9‐Anthryl‐3‐guaiazulenylmethylium Hexafluorophosphate.
Authors: Takekuma Shin‐ichi , Sasaki Kaori , Nakatsuji Miwa , Sasaki Masato , Minematsu Toshie , Takekuma Hideko 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of New Hexahydro‐ and Octahydropyrido[1,2‐c]pyrimidine Derivatives with an Arylpiperazine Moiety as Ligands for 5‐HT1A and 5‐HT2A Receptors. Part 2.
Authors: Herold F. , Kleps J. , Nowak G. , Maj M. 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chiral Metal Complexes in Asymmetric Catalysis
Authors: Moberg Christina , Belda Oscar , Hallman Kristina , Stranne Robert , Svensson Mats , Vasse Jean‐Luc , Wondimagegn Tebikie , Zalubovskis Raivis 
Published: April 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantioselective Recognition of Aspartic Acids by Chiral Ligand Exchange Potentiometry
Authors: Zhou Yanxiu , Yu Bin , Levon Kalle , Nagaoka Tsutomu 
Published: April 2004

AbstractEnantioselective resolution is realized by combining potentiometry with ligand exchange (CE) in a new method called chiral ligand exchange potentiometry (CLEP). A chiral selector, N‐carbobenzoxy‐L‐aspartic acid (N‐CBZ‐L‐Asp), preferentially recognizes D‐aspartic acid (D‐Asp) and undergoes ligand exchange with the enantiomeric labile coordination complexes of [Cu(II)(D‐Asp)2] or [Cu(II)(L‐Asp)2] to form a diastereoisomeric complex [(D‐Asp)Cu(II)(N‐CBZ‐L‐Asp)] (a) or [(L‐Asp)Cu(II)(N‐CBZ‐L‐Asp)] (b). Considerable stereoselectivity occurs in the formation of these diastereoisomeric complexes, and their net charges were −2 (a) and 0 (b), respectively, resulting in different Nernst factor (electrode slope), thus enabling chiral D‐Asp to be distinguished by potentiometry without any pre‐ or postseparation processes.
Potentiometric Stripping of Arsenic(III) Using a Wall‐Jet Flow Cell and Gold(III) Solution as Chemical Reoxidant
Authors: Muñoz Emma , Palmero Susana 
Published: April 2004

AbstractIn the proposed method As(III) is determined with a wall‐jet flow cell by means of potentiostatic co‐deposition of Au(III) and As(III) at a glassy‐carbon electrode and subsequent chemical stripping with Au(III). Factors affecting sensitivity and precision including acidity, Au(III) concentration, electrodeposition potential and flow rate were optimized. Optimum determination of As(III) in solutions containing 160 mg L−1 and 1.2 M hydrochloric acid was accomplished with an electrolysis potential of −0.1 V (vs. Ag/AgCl) and a flow rate of 0.59 mL min−1. Different linear concentration ranges were achieved under these conditions with good precision and relative standard deviations between 6–9%. The detection limit obtained after 120 s of electrolysis was 0.55 μg L−1.
Evidence for semantic learning in profound amnesia: An investigation with patient H.M.
Authors: O'Kane Gail , Kensinger Elizabeth A. , Corkin Suzanne 
Published: April 2004

AbstractUntil recently, it seemed unlikely that any semantic knowledge could be acquired following extensive bilateral damage to the medial temporal lobes (MTL). Although recent studies have demonstrated some semantic learning in amnesic patients, questions remain regarding the limits of this capacity and the extent to which it relies on those patients' residual MTL function. The present study examined whether detailed, semantic memory could be acquired by a patient with no functioning hippocampus. We used cued recall and forced‐choice recognition tasks to investigate whether the patient H.M. had acquired knowledge of people who became famous after the onset of his amnesia. Results revealed that, with first names provided as cues, he was able to recall the corresponding famous last name for 12 of 35 postoperatively famous personalities. This number nearly doubled when semantic cues were added, suggesting that his knowledge of the names was not limited to perceptual information, but was incorporated in a semantic network capable of supporting explicit recall. In forced‐choice recognition, H.M. discriminated 87% of postmorbid famous names from foils. Critically, he was able to provide uniquely identifying semantic facts for one‐third of these recognized names, describing John Glenn, for example, as “the first rocketeer” and Lee Harvey Oswald as a man who “assassinated the president.” Although H.M.'s semantic learning was clearly impaired, the results provide robust, unambiguous evidence that some new semantic learning can be supported by structures beyond the hippocampus proper. © 2004 Wiley‐Liss, Inc.