bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Implementing a Standardized Surveillance Program on Cardiac Neurodevelopmental Program Referral Outcomes
Authors: Hennrick Heather , Miller Elizabeth , Lai Wyman , Carmona Viannae , Flores Ana-Mercedes , Olson Marissa , Kong Dianne , Tan Alexander 
Published: November 2023

Abstract
Background:Differences in surveillance methods have resulted in significant variability in referral outcomes across cardiac neurodevelopmental programs, with frequent barriers to referral completion including high no-show rates, lack of education, and inaccessibility for underrepresented populations. The purpose of this study was to describe implementation of a standardized surveillance program and investigate impact on referral outcomes over a two-year period.
Methods:Between fiscal years 2021 and 2022, a surveillance program was implemented which standardized assessment of neurodevelopmental risk via a checklist as well as family education and referral procedures. All patients referred to the cardiac neurodevelopmental program during these two fiscal years were included in the analysis, representing one cohort before implementation and one cohort after implementation.
Results:Implementation of the formal surveillance program resulted in a 66.7% increase in referral volume. Proportions of both incomplete referrals (z = 2.00, p < 0.05) and incomplete referrals due to physician-related factors (z = 4.34, p < 0.01) were significantly higher after implementation. A significant association was found after implementation between referral completion and race/ethnicity (x2 = 14.08, p < 0.01) due to a significantly higher number of completed referrals compared to expected values for patients identifying as Hispanic/Latino.
Conclusions:This study describes the successful implementation of a standardized surveillance program, including improvements to referral volume and outcomes, and benefits to patients/families, clinicians, and systems. Findings also support implementation of methods that improve accessibility for historically marginalized groups at greatest risk for disparities in access and quality of care.
Application research on durability and low carbonation of concrete modified with limestone powder and silica ash
Authors: Ma Chao , Yao Zhaolong , Yang Zhao , Liu Pengfei , Liu Jie , Chen Fuxiang 
Published: November 2023

Abstract
In order to reduce the carbon emissions caused by the use of a large amount of concrete during tunnel construction and achieve the goal of green and low-carbon construction. This paper develops a low- carbon modified concrete by adding limestone powder (LP) and silica fume (SF) on the basis of ordinary concrete mixture. This paper analyzes the effects of different LP and SF dosages as well as the water-to-cement (w/c) ratios on rheological properties, early-age heat release and compressive strength of the material. The workability of the cementitious material was further comprehensively evaluated by introducing the expansion and water absorption indicators. The results confirmed that the incorporation of more than 15% LP led to a slight decrease in the strength of the cementitious material; however, it improved the pumpability and significantly reduced early-age heat release of the cementitious material, which contributed to the control of temperature-induced cracking in cementitious material. Also, the addition of SF with a content of more than 5% could further optimize the pumpability, which was beneficial for long-distance pumping of high-performance cementitious materials. Modified concrete has good mechanical properties, good pumpability, and low hydration heat. This study developed a low-carbon concrete material for green construction of tunnel construction, further promoting the efficient and clean utilization of LP and SF.
Groundwater quality and human health risk assessment in urban and peri-urban regions of Jashore, Bangladesh
Authors: Ghosh Gopal Chandra , Chakraborty Tapos Kumar , Shekder Nipa , Tanin Taniya Aktar , Habib Ahsan , Zaman Samina 
Published: November 2023

Abstract
This study investigated the groundwater quality and its associated human health risks in the urban and peri-urban areas of Jashore, Bangladesh, where groundwater samples were collected from 67 randomly selected tube wells. The concentration of arsenic, iron, and manganese was analyzed by atomic absorption spectroscopy (AAS). The water quality index indicates that about 89 and 43% of groundwater samples are not consumable for the urban and peri-urban areas, respectively. All of the source water is significantly contaminated with Escherichia coli for urban (31 ± 17.77 CFU/100 mL) and peri-urban areas (76.12 ± 35.17 CFU/100 mL), where about 67 and 57% of water source has intermediate and high microbial risk of E. coli for urban and peri-urban areas, respectively. Children and adults face unacceptable non-carcinogenic health risks for the urban area (4.13–10.67 for adults; 9.65–24.91 for children) and peri-urban area (1.05–5.58 for adults; 2.46–13.03 for children) via oral ingestion. Both groups (e.g. children = 4.25E-03 to 1.10E-02 and adult = 1.82E-03 to 4.71E-03 for urban regions; children = 1E-03 to 5E-03 and adult = 4.29E0-04 to 2.14E-03 for peri-urban regions) face undesirable carcinogenic risks from arsenic. In addition, children are suspected to have 2.33 times higher non-carcinogenic and carcinogenic health risks than adults.
Simulation and optimization of Lar Dam reservoir storage under climate change conditions
Authors: Sadeghijou Hediyeh , Sarraf Amirpouya , Ahmadi Hassan 
Published: November 2023

Abstract

In this research, A 15-year impact of climate change in Lar Dam has been investigated. The results showed that in the case of climate change under three scenarios, Tmax and the Tmin have increased by 5, 5.23, 6.2% and 3.5, 5.6, 5.17%, respectively, and the amount of precipitation increased by 8.55, 9.5, 13%, respectively. Also, the highest rainfall will be in 2031 and the lowest will be in 2036. Based on the intermediate state of the scenarios, the amount of runoff was obtained and the reliability index was calculated according to the upstream runoff and downstream needs for drinking, agriculture, and environment. The simulation was also performed in the WEAP model. The findings showed that the highest reliability was 86.60% of the agriculture, and by using the optimization of a honey badger and Harmony Search Algorithm, it was found that the reliability is approximately 5.06 and 1.73% higher than the simulation. In comparison with the optimization algorithms, due to the smaller value of the objective function of the HBA and the greater reliability of it, the result showed that performance of this algorithm was better and it has a faster calculation.
Recovery of precious metals from processed wastewater: conventional techniques nexus advanced and pragmatic alternatives
Authors: Adeeyo Adeyemi Ojutalayo , Bello Olugbenga Solomon , Agboola Oluwatobi Samuel , Adeeyo Rebecca Oyedoyin , Oyetade Joshua Akinropo , Alabi Mercy Adewumi , Edokpayi Joshua Nosa , Makungo Rachel 
Published: November 2023

AbstractThe loss of highly sought-after metals such as gold, silver, and platinum during extraction processes not only constitutes a significant waste of valuable resources but also contributes to alarming environmental pollution. The ever-growing adverse impacts of these highly valued metals significantly increase the contamination of water bodies on discharge, while reducing the reusability potential of their corresponding processed wastewater. It is, therefore, of great interest to identify pragmatic solutions for the recovery of precious materials from processed water. In this review, pollution from targeted precious metals such as gold, silver, platinum, palladium, iridium, ruthenium, and rhodium was reviewed and analyzed. Also, the hazardous effects are elicited, and detection techniques are enumerated. An insightful approach to more recent treatment techniques was also discussed. The study reveals nano- and bio-sorption techniques as adoptable pragmatic alternatives, among other techniques, especially for industrial applications with merits of cost, time, waste management, and eco-friendliness. The results indicate that gold (46.2%), palladium (23.1%), platinum (19.2%), and silver (11.5%) are of utmost interest when considering recent recovery techniques. High yield and cost analysis reduction are reasons for the observed preference of this recovery process when considering groups of precious metals. The challenges and prospects of nanomaterials are highlighted.
Fenton process enhanced by metal sulfide for treating the actual evaporated mother liquid of gas field wastewater
Authors: Yao Bing , Chen Ying , Wang Mengzhe , Liu Min 
Published: November 2023

Abstract

Evaporated mother liquor of gas field wastewater (EML-GFW) is a form of wastewater generated by the triple-effect evaporation treatment of gas field wastewater containing complex pollutants. In this study, four metal sulfides, CuS, ZnS, MoS2, and WS2, were used to strengthen the Fenton process in EML-GFW treatment. The optimum Fenton/ZnS process for the highest removal of TOC from EML-GFW was achieved at the initial pH of 3.0 and in a mixture of FeSO4·7H2O:ZnS:H2O2 in the ratio of 30 g/L:10 g/L:1.2 mol/L, with a TOC removal efficiency of 74.5%. The organic components analysis of EML-GFW over four distinct periods demonstrated that the presence of N,N-dimethylethanolamine (DMEA) persisted and accounted for the greatest proportion of pollutants, identifying it as the characteristic pollutant. The TOC removal mechanism by Fenton/ZnS was revealed via analysis of organic materials obtained from the Fenton/ZnS process, tert-butanol quenching experiment, and illumination experiment. ZnS-generated hole–electron pairs under illumination, which promoted the reduction of Fe3+ to Fe2+, followed by an acceleration of •OH generation, thus improving TOC removal efficiency. The Fenton/ZnS process improved the treatment of EML-GFW in the laboratory, providing strong data support and theoretical guidance for expanding this technology at the gas field project site.
Selection of Real-Coded Genetic Algorithm parameters in solving simulation–optimization problems for the design of water distribution networks
Authors: Hemanth Sai Kumar Vidavaluru , S.K. Pramada 
Published: November 2023

Abstract

The design of the water distribution network (WDN) is very difficult mainly due to the nonlinear relation between head and flow. The distribution network should also be cost-effective. In any simulation–optimization approach, the computational time requirement is very high for very complex problems. The optimization module plays a crucial role in reducing the computational time. This study aims to apply a simulation–optimization approach to designing a WDN. EPANET is selected as the simulation model and Real-Coded Genetic Algorithm (RCGA) is selected as the optimization module. To link the simulation module with the optimization module, a program is written in MATLAB. The developed simulation–optimization approach was applied to two benchmark network problems to check the suitability of the method. The parameters of the RCGA were optimized for the two networks. The computational efficiency of the developed simulation–optimization model is checked based on the number of function evaluations. For both networks, the number of function evaluations to get the optimum network design was less than the number of function evaluations required for other methods mentioned in the literature.
An improved equation development for longitudinal dispersion coefficient
Authors: Ukpaka Chinedu , Agunwamba Jonah Chukwuemeka 
Published: November 2023

Abstract
The model developed in this paper is an improved equation for the longitudinal dispersion coefficient, which is an important parameter used to monitor and check the assimilatory capacity of rivers. This research incorporates total suspended solids (Ss) and total dissolved solids (Ds) to other selected functional parameters in order to investigate the contributions of Ss and Ds on the longitudinal dispersion coefficient. The results obtained from research indicates that the presence of Ss and Ds affects longitudinal dispersion coefficient as it reduces the magnitude of Dl values. The measured values of longitudinal dispersion coefficient estimated in this study vary between 71 and 104.4 m2 s-1. The percentage of Dr values estimated to be within 0.0 and 0.3 were 50.0% and within −0.3 and 0.0 were 50% for the developed equation and this indicates a degree of accuracy of 100.0%. While for Seo and Cheong, the percentage of Dr values determined to be within 0.0 and 0.3 were 63.3% and within −0.3 and 0.0 were 30% and gives a degree of accuracy of 93.3% and others are poor. SE, NME and MME results show a high accuracy for the derived equation revealing the adequacy of the derived equation in the estimation of D.
Characterization and treatment of tunneling wastewater using natural and chemical coagulants
Authors: Ghorbani Mooselu Mehrdad , Liltved Helge , Akhtar Naureen 
Published: November 2023

Abstract

Particles are a concern regarding tunneling wastewater, but gaps remain in understanding metal(loid)s content and coagulation efficiency. In this research, characterization of the wastewaters before and after treatment was investigated by chemical analysis and various techniques for particle characterization. Then, laboratory work was conducted to evaluate effectiveness of sedimentation and use of coagulants to remove particles and particle-associated contaminants. Both natural (chitosan) and chemical coagulants (ferric chloride sulfates and polyaluminium chloride solution), were applied in a jar test system. The results indicated that short-time sedimentation alone substantially reduced the particle content and particle-associated pollutants, including metal(loid)s, while subsequent chemical coagulation was required to comply with discharge limits. The optimum dosages of chitosan, PIX, and PAX for water 1 after pre-treatment (15 min sedimentation) were 1 mg/L, 3 mg Fe/L, and 3 mg Al/L, respectively, while a dosage of 2 mg Al/L gave the best results in water 3. Furthermore, chemical coagulation significantly decreased the volume density of particles in the diameter range of 1–100 μm, showing that coagulants are efficient for the removal of smaller particles not removed by conventional sedimentation.
Physiological and Pathological Roles of NTSR2 in Several Organs and
Diseases (Review)
Authors: Yang Yuting , Zhang Wenxin , Wei Kun , Hu Fei , Wu Song , Ma Yuan , Ouyang Qing 
Published: November 2023

Abstract:
Neurotensin (NTS) and its receptors (NTSRs) have long been the subject of study and
have shown to have a vital function in a variety of systems. They are specifically implicated in the
development of tumors and have both oncogenic and anti-apoptotic effects. Neurotensin receptor 2
(NTSR2), like NTSR1, belongs to the G protein-coupled receptor family and has been linked to
analgesia, mental disorders, and hematological cancers. However, several research reports have
revealed that it exists in numerous different systems. As a result, it seems to be an extremely
promising therapeutic target for a variety of diseases. As NTSR2 is particularly prevalent in the
brain and has different distribution and developmental characteristics from NTSR1, it may play a
specific role in the nervous system. The present review summarizes the expression and function of
NTSR2 in different systems, to highlight its potential as a diagnostic tool or therapeutic target.
Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating
the miR-143/TFAP2B Axis in Prostate Cancer
Authors: Lv Zhong , Shi Yunfeng , Wu Haoran , Cao Kai , Liu Xiaowu , Wang Chengyue 
Published: November 2023

Background:
More and more investigations reveal that circular RNAs (circRNAs) are
involved in cancer progression. CircRNA UBAP2 was closely related to prostate cancer. However,
the biological function and specifical mechanism of circUBAP2 are still poorly discovered in
prostate cancer (PCa).

Objective:
This study aims to explore the biological function and mechanism of circUBAP2 in PCa.

Methods:
The levels of mRNA and proteins were assessed by qRT-PCR assay and Western blot,
respectively. Cell growth, migration, and invasion ability were measured using CCK-8 assay and
Transwell assay. Apoptosis was assessed using flow cytometry. The interactions between
circUBAP2, miR-143, and TFAP2B were determined by luciferase report assay. The tumor growth
was determined by in vivo tumor formation assay. The tumor morphology was assessed using H&E
staining assay, and immunohistochemistry assay was conducted to assess the level of KI67.

Results:
We found circUBAP2 and TFAP2B were notably elevated, while miR-143 was largely
attenuated in prostate cancer cells and tissues. CircUBAP2 was found to affect cell viability,
metastasis and EMT, while attenuating the apoptosis rate of prostate cancer cells. CircUBAP2
directly targeted miR-143, and miR-143 inhibitor could reverse the effects that circUBAP2
interference-induced in prostate cancer cells. TFAP2B is directly bound to miR-143, and overexpression
of TFAP2B could attenuate the influences that miR-143-induced in prostate cancer cells.

Conclusion:
CircUBAP2 promoted prostate cancer progression via miR-143/TFAP2B axis.
Design, Synthesis, Reactions, Molecular Docking, Antitumor Activities of Novel
Naphthopyran, Naphthopyranopyrimidines, and Naphthoyranotriazolopyrimidine
Derivatives
Authors: Ahmed Borik Rita Mohammed , Amri Nasser Jaber Hadi , Mukhrish Yousef Essa , Abd El-Wahab Ashraf Hassan Fekry , Mohamed Hany Mostafa , Ibrahim Diaa Abd El-Samie , Deeb Ahmed Deeb Hassan 
Published: November 2023

Abstract:
In ethanolic piperidine solution, the interaction of 6-bromonaphthalen-2-ol (1) with α-
cyano-p-chlorocinnamonitrile (2a) or ethyl α-cyano-p-chlorocinnamate (2b) yielded 4Hnaphtho[
2,1-b]pyran-3-carbonitrile (3a) and 4H-naphtho[2,1-b]pyran-3-carboxylate (3b). The
naphthopyran derivatives (3a, b) reacted with electrophilic reagents afforded naphthopyranopyrimidines
and naphthopyrano-triazolopyrimidine derivatives. The structures of the newly synthesized
compounds are confirmed through spectral analysis using NMR, IR, and MS spectroscopy.
The anticancer efficacy of all compounds was investigated against three cancer cell lines: MCF-
7, HeLa, and PC-3, along with a molecular docking study.
Development of a Combined Oxidative Stress and Endoplasmic Reticulum Stress-Related Prognostic Signature for Hepatocellular Carcinoma
Authors: Ma Hui , Li Zhongchen , Chen Rongxin , Ren Zhenggang 
Published: November 2023

Background:
Oxidative stress and endoplasmic reticulum stress are important components
of the cellular stress process, which plays a critical role in tumor initiation and progression.

Methods:
First, the correlation between oxidative stress and endoplasmic reticulum stress was
detected in 68 human hepatocellular carcinoma (HCC) tissue microarray samples by immunohistochemistry.
Differentially expressed oxidative stress- and endoplasmic reticulum stressrelated
genes (OESGs) then were screened in HCC. Next, an OESGs prognostic signature was
constructed for HCC in the training cohort (TCGA-LIHC from The Cancer Genome Atlas), by
least absolute shrinkage and selection operator Cox and stepwise Cox regression analyses, and
was verified in the external cohort (GSE14520 from the Gene Expression Omnibus). The MCP
counter was employed to evaluate immune cell infiltration. The C-index was used to evaluate the
predictive power of prognostic signature. Finally, a prognostic nomogram model was constructed
to predict the survival probability of patients with HCC based on the results of Cox regression
analysis.

Results:
We demonstrated a positive correlation between oxidative stress and endoplasmic reticulum
stress in human HCC samples. We then identified five OESGs as a prognostic signature
consisting of IL18RAP, ECT2, PPARGC1A, STC2, and NQO1 for HCC. Related risk scores correlated
with tumor stage, grade, and response to transcatheter arterial chemoembolization therapy,
and the higher risk score group had less T cells, CD8+ T cells, cytotoxic lymphocytes and
natural killer cell infiltration. The C-index of our OESGs prognostic signature was superior to
four previously published signatures. Furthermore, we developed a nomogram based on the
OESGs prognostic signature and clinical parameters for patients with HCC that is an effective
quantitative analysis tool to predict patient survival.

Conclusion:
The OESGs signature showed excellent performance in predicting survival and
therapeutic responses for patients with HCC.
Patterns of Gene Expression Profiles Associated with Colorectal Cancer in Colorectal Mucosa by Using Machine Learning Methods
Authors: Ren Jing Xin , Chen Lei , Guo Wei , Feng Kai Yan , Cai Yu-Dong , Huang Tao 
Published: November 2023

Background:
Colorectal cancer (CRC) has a very high incidence and lethality rate and
is one of the most dangerous cancer types. Timely diagnosis can effectively reduce the incidence
of colorectal cancer. Changes in para-cancerous tissues may serve as an early signal for tumorigenesis.
Comparison of the differences in gene expression between para-cancerous and normal
mucosa can help in the diagnosis of CRC and understanding the mechanisms of development.

Objectives:
This study aimed to identify specific genes at the level of gene expression, which are
expressed in normal mucosa and may be predictive of CRC risk.

Methods:
A machine learning approach was used to analyze transcriptomic data in 459 samples
of normal colonic mucosal tissue from 322 CRC cases and 137 non-CRC, in which each sample
contained 28,706 gene expression levels. The genes were ranked using four ranking methods
based on importance estimation (LASSO, LightGBM, MCFS, and mRMR) and four classification
algorithms (decision tree [DT], K-nearest neighbor [KNN], random forest [RF], and support
vector machine [SVM]) were combined with incremental feature selection [IFS] methods to construct
a prediction model with excellent performance.

Result:
The top-ranked genes, namely, HOXD12, CDH1, and S100A12, were associated with
tumorigenesis based on previous studies.

Conclusion:
This study summarized four sets of quantitative classification rules based on the DT
algorithm, providing clues for understanding the microenvironmental changes caused by CRC.
According to the rules, the effect of CRC on normal mucosa can be determined.