bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Therapeutic Mechanisms of Shenyan Oral Liquid I Against Chronic Kidney Disease Based on Network Pharmacology and Experimental Validation
Authors: Cheng Xudong , Liang Guoqiang , Liu Min , Song Rujun , Zhou Lan , Ren Yan , Huang Yuyu , Jin Weimin , Jiang Chunbo 
Published: November 2023

Background:
Chronic Kidney Disease (CKD) leads to structural and functional abnormalities
of the kidneys and seriously jeopardizes human health. Shenyan Oral Liquid (SOLI),
a Chinese medicinal preparation, has been reported to protect podocytes in patients with chronic
kidney disease (CKD).

Objective:
The objective of this study is to investigate the mechanism of action of the Chinese
medicinal preparation Senyan Oral Liquid (SOLI) in the treatment of CKD by protecting podocytes
through network pharmacology technology and experimental validation.

Methods:
Compounds of SOLI and targets of CKD disease were collected and screened. The
SOLI network of bioactive compounds targeting CKD and the protein-protein interaction (PPI)
network were constructed using Cytoscape software and the STRING online database. Gene ontology
(GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were
performed using the R software Cluster Profiler package. Molecular docking was performed using
Autodock software to verify the binding ability of bioactive compounds and target genes. Subsequently,
the potential mechanism of SOLI on CKD predicted by network pharmacological analysis
was experimentally studied and verified in an adriamycin-induced nephropathy rat model.

Results:
A total of 81 targets of SOLI components acting on CKD were identified. The results of
the PPI analysis clarified that five key target genes (TNF, AKT1, IL6, VEGFA, and TP53) play a
critical role in the treatment of CKD by SOLI. The GO analysis and KEGG enrichment analysis
indicated that SOLI acts through multiple pathways, including the PI3K/AKT signaling pathway
against CKD. Molecular docking showed that the main compounds of SOLI and five key genes
had strong binding affinity. In a rat model of adriamycin-induced nephropathy, SOLI significantly
ameliorated disease symptoms and improved renal histopathology. Mechanistic studies
showed that SOLI upregulated the expression level of Nephrin, inhibited the PI3K/AKT pathway
in renal tissues, and ultimately suppressed the activation of autophagy-related proteins in CKD.

Conclusion:
SOLI exerted a renoprotective effect by regulating the Nephrin-PI3K/AKT autophagy
signaling pathway, and these findings provide new ideas for the development of SOLI-based
therapeutic approaches for CKD.
Chalcones as Potential Cyclooxygenase-2 Inhibitors: A Review
Authors: Mahboubi-Rabbani Mohammad , Zarei Rosa , Baradaran Mehdi , Bayanati Maryam , Zarghi Afshin 
Published: November 2023

Abstract:
Cyclooxygenases (COXs) play a pivotal role in inflammation, a complex phenomenon required in
human defense, but also involved in the emergence of insidious human disorders. Currently-used COX-1 inhibitors
(Non-Steroidal Anti-Inflammatory Drugs-NSAIDs), as the most frequent choices for the treatment of chronic
inflammatory diseases, have been identified to be associated with a variety of adverse drug reactions, especially
dyspepsia, as well as peptic ulcer, which lead to diminished output. Moreover, the structural similarities of COX-
1 and -2, along with the availability of comprehensive information about the three-dimensional structure of COX-
2, co-crystallized with various inhibitors, search selective COX-2 inhibitors a formidable challenge. COX-2 inhibitors
were shown to minimize the incidence of metastasis in cancer patients when administered preoperatively.
Developing selective COX-2 inhibitors to tackle both cancer and chronic inflammatory illnesses has been identified
as a promising research direction in recent decades. Identifying innovative scaffolds to integrate as the major
component of future COX-2 inhibitors is critical in this regard. The presence of a central, ɑ, β-unsaturated carbonyl-
containing scaffold, as a characteristic structural pattern in many selective COX-2 inhibitors, along with a
huge count of chalcone-based anticancer agents representing the basic idea of this review; providing a survey of
the most recently published literature concerning development of chalcone analogs as novel COX-2 inhibitors
until 2022 with efficient anticancer activity. A brief overview of the most recent developments concerning structure-
activity relationship insights and mechanisms is also reported, helping pave the road for additional investigation.
Quantifying Health Policy Uncertainty in China Using Newspapers: Text Mining Study
Authors: Chen Chen , Zhu Junli 
Published: November 2023

Background
From the severe acute respiratory syndrome (SARS) outbreak in 2003 to the COVID-19 pandemic in 2019, a series of health measures and policies have been introduced from the central to the local level in China. However, no study has constructed an uncertainty index that can reflect the volatility, risk, and policy characteristics of the health environment.

Objective
We used text mining analysis on mainstream newspapers to quantify the volume of reports about health policy and the total number of news articles and to construct a series of indexes that could reflect the uncertainty of health policy in China.

Methods
Using the Wisenews database, 11 of the most influential newspapers in mainland China were selected to obtain the sample articles. The health policy uncertainty (HPU) index for each month from 2003 to 2022 was constructed by searching articles containing the specified keywords and calculating their frequency. Robustness tests were conducted through correlation analysis. The HPU index was plotted using STATA (version 16.0), and a comparative analysis of the China and US HPU indexes was then performed.

Results
We retrieved 6482 sample articles from 7.49 million news articles in 11 newspapers. The China HPU index was constructed, and the robustness test showed a correlation coefficient greater than 0.74, which indicates good robustness. Key health events can cause index fluctuations. At the beginning of COVID-19 (May 2020), the HPU index climbed to 502.0. In December 2022, China’s HPU index reached its highest value of 613.8 after the release of the “New Ten Rules” pandemic prevention and control policy. There were significant differences in HPU index fluctuations between China and the United States during SARS and COVID-19, as well as during the Affordable Care Act period.

Conclusions
National health policy is a guide for health development, and uncertainty in health policy can affect not only the implementation of policy by managers but also the health-seeking behavior of the people. Here, we conclude that changes in critical health policies, major national or international events, and infectious diseases with widespread impact can create significant uncertainty in China’s health policies. The uncertainty of health policies in China and the United States is quite different due to different political systems and news environments. What is the same is that COVID-19 has brought great policy volatility to both countries. To the best of our knowledge, our work is the first systematic text mining study of HPU in China.
Normalización, clasificación y utilidad de toponimias a través de plataformas de geovisualización y webmap en Sacatepéquez, Guatemala, C.A.
Authors: Santos Mansilla Edwin Guillermo , Cano González Jorge Luis Eduardo , Ixjotop Puac Jorge Anselmo 
Published: November 2023

En este estudio se analizó la contribución de la normalización (según la Academia de Lenguas Mayas de Guatemala) para la geovisualización en un web-map. Se realizaron clasificaciones que parten de la interpretación de los topónimos normalizados (considerando la traducción del nombre de lugar y el significado que los comunitarios les han otorgado a dichos lugares) dado que, según Lefebvre & Paredes Martínez, las comunidades aplican sus propias categorías al territorio. Se realizó la contextualización de las interrelaciones de la toponimia con el entorno (comunidades y los recursos naturales) para visualizarse en un web-map y un dashboard. Dicho análisis permitió esclarecer algunas de las interrogantes en relación con la geovisualizacion de los recursos naturales y la toponimia de Sacatepéquez. En muchas ocasiones los pobladores de estas comunidades son señalados de ignorantes o no progresistas por oponerse a diversos proyectos de desarrollo (construcciones a gran escala); sin embargo, no se considera la importancia y el significado que tienen estos lugares para las comunidades, ya que, para ellas, muchos lugares poseen categoría de símbolo lingüístico (Rodríguez de Castro y Vázquez Hoehne, 2013). Desde el enfoque sociolingüístico de la toponimia, se realizaron inferencias más profundas, aplicadas al lenguaje de la comunidad (en el idioma maya kaqchikel); que involucran elementos pertinentes para la descripción del territorio, que pueden ser sustantivos, predicados o verbos. Sin embargo, los planificadores de los proyectos hacen caso omiso a las interrelaciones existentes entre el territorio y la cosmovisión de los habitantes. Actualmente muchos topónimos están nombrados de forma castellanizada (una mezcla entre idioma maya kaqchikel y español) o bien, son nombrados completamente en español, utilizando una traducción literal poco lógica.
Estratégia de Difusão Agressiva para Aumentar a Vazão do Algoritmo de Consenso HyperPaxos
Authors: Pereira Djenifer R. , Kiotheka Fernando M. , Duarte Jr Elias P. 
Published: November 2023

Algoritmos de consenso distribuído são essenciais para sistemas de armazenamento, bancos de dados, controle de acesso e orquestração de aplicações em nuvem. Este trabalho apresenta uma estratégia para melhorar a vazão do algoritmo HyperPaxos em termos de decisões por segundo. O algoritmo HyperPaxos é uma versão hierárquica de um dos principais algoritmos de consenso, o Paxos. O HyperPaxos é baseado na topologia virtual hierárquica vCube, que apresenta diversas propriedades logarítmicas. Os acceptors são organizados em clusters e os proposers executam as duas fases do Paxos escolhendo um acceptor dito difusor. O difusor é responsável por retransmitir as mensagens para os demais acceptors sobre o vCube. Neste trabalho, propomos que o difusor adote uma estratégia de difusão agressiva para transmitir, de uma só vez, as mensagens para uma maioria de acceptors paralelamente. A estratégia proposta foi implementada e comparada à versão original. Resultados obtidos mostram o desempenho superior da estratégia proposta em todos os cenários testados.
“¿Quién hablará cuando callemos?”: compromiso y memoria en La voz perdida / La veu perduda de Angelina Gatell
Authors: Lozano Marín Laura 
Published: November 2023

En el presente artículo se propone analizar el poemario bilingüe de la escritora catalana Angelina Gatell publicado de manera póstuma en 2017 y titulado La voz perdida / La veu perduda.
El objetivo fundamental del trabajo es estudiar la presencia y la utilización del compromiso social y la memoria este último libro de poemas de la autora, para cuyo análisis se ha recurrido también a la autobiografía Memorias y desmemorias (2012) y diferentes entrevistas en las que la escritora plasmó su testimonio.
PEMANFAATAN LIMBAH KULIT KOPI DAN PRAKTIK PEMBUATAN SABUN CASCARA KOPI
Authors: Widyasanti Asri , Muharram Alifiansyah 
Published: November 2023

Kopi (Coffea sp.) merupakan komoditas perkebunan yang banyak dibudidayakan di Indonesia. Dusun Cikoneng Babakan, Desa Cibiru Wetan merupakan salah satu wilayah yang memiliki banyak perkebunan kopi rakyat yang sudah dikenal baik oleh masyarakat dengan nama kopi manglayang. Proses pengolahan buah kopi menghasilkan kulit buah kopi yang berlimpah dan belum termanfaatkan dengan optimal. Maka dari itu, diperlukan upaya untuk mengurangi limbah kulit kopi salah satu adalah dengan memanfaatkan limbah kulit buah kopi menjadi produk yang memiliki nilai tambah tinggi. Tujuan pengabdian kepada masyarakat adalah memberikan penyuluhan dan praktik mengenai pemanfaatan limbah kulit kopi menjadi sabun ‘Casa soap”, sehingga sabun ini dapat menjadi produk unggulan atau souvenir khas Cibiru Wetan. Metode PPM yang digunakan adalah pendekatan partisipatori. Dari hasil kegiatan yang telah dilakukan dapat ditarik kesimpulan bahwa: (1) Kegiatan PKM ini dapat memberikan pengetahuan dan ketrampilan masyarakat untuk mengolah limbah kulit kopi menjadi sabun; (2) Peserta pelatihan terutama kelompok ibu-ibu PKK mengikuti praktik pembuatan sabun dengan antusias. Praktik pembuatan produk ini juga memberikan motivasi usaha bagi peserta pelatihan untuk mengembangkan produk lebih lanjut dengan bekerjasama dengan Badan Usaha Milik Desa (Bumdes) Desa Cibiru Wetan. Rekomendasi sebagai tindak lanjut kegiatan yaitu pengrajin sabun Desa Cibiru Wetan sebaiknya terus bekerjasama dengan Universitas Padjadjaran dalam bentuk desa binaan sehingga pendampingan, monitoring kualitas produk akhir, serta inovasi produk dapat terus dilakukan.
APPLYING GENDER DIFFERENCES IN PHONOLOGICAL AWARENESS TO ENHANCE STUDENTS’ READING ABILITY
Authors: Winarto Eline Rozaliya , Aprianti Fitri 
Published: November 2023

Phonological awareness is the first stage in enhancing kids' reading skills. Phonological awareness provides the foundation for youngsters to associate written letters with their voices, which will help them understand the reading process. Primary school reading abilities provide the groundwork for subsequent reading success. The research technique that utilized to conduct study on phonological awareness and reading ability of male and female primary school pupils is a research method that combines quantitative and qualitative data, commonly known as the Mixed-Method. To obtain quantitative data, this method employs one experimental group, whereas to obtain qualitative data, classroom observation, questionnaires, and interviews conducted on experimental. The subjects of this study were low-grade male and female pupils at primary schools in Cirebon. A basic random sampling procedure is used to determine the samples. There were four types of data gathering procedures used in this study: phonological awareness, observation, questionnaires, and interviews. This study leads to several findings. First, the findings are broadly consistent with previous research in the field of PA in primary children. The study discovered a consistent developmental trajectory in the majority of the PA tasks in favor of primary children. In addition, females outperformed males in some PA subtests. In order to eliminate obstacles to advancing their reading abilities, elementary students must be trained on PA exercises.
A (NiMnCo)-Metal-Organic Framework (MOF) as active material for Lithium-ion battery electrodes
Authors: Cognet Marine , Gutel Thibaut , Peralta David , Maynadié Jerome , Cambedouzou Julien , Carboni Michaël , Meyer Daniel 
Published: November 2023

A (NiMnCo)-Metal-Organic Framework and its oxidized and pyrolysed derivatives have been tested as electrode materials for lithium-ion batteries. Materials have been fully characterized by Scanning Electron Microscopy (SEM), powder X-Ray Diffraction (XRD), Thermogravimetric Analyses (TGA), Infrared (IR) spectroscopy and electrochemical properties have been determined in coin cells using lithium metal as the counter electrode. Studies have revealed specific capacities of 860 mAh g−1 and 800 mAh g−1 at 15 mA g−1 respectively for the MOF and the oxide (690 and 190 mAh g−1 after 50 cycles) whereas the corresponding pyrolysed compound has shown limited electrochemical performances. Ex situ XRD has been performed to highlight the evolution of the material structure during cycling. These results show that electrochemical storage is based on a conversion reaction.
The sharp turn: Backward rupture branching during the 2023 Mw 7.8 Kahramanmaraş (Türkiye) earthquake
Authors: Ding Xiaotian , Xu Shiqing , Xie Yuqing , Van den Ende Martijn , Premus Jan , Ampuero Jean-Paul 
Published: November 2023

Multiple lines of evidence indicate that the 2023 Mw 7.8 Kahramanmaraş (Türkiye) earthquake started on a splay fault, then branched bilaterally onto the nearby East Anatolian Fault (EAF). This rupture pattern includes one feature previously deemed implausible, called backward rupture branching: rupture propagating from the splay fault onto the SW EAF segment through a sharp corner (with an acute angle between the two faults). To understand this feature, we perform 2.5-D dynamic rupture simulations considering a large set of possible scenarios. We find that both subshear and supershear ruptures on the splay fault can trigger bilateral ruptures on the EAF, which themselves can be either subshear, supershear, or a mixture of the two. In most cases, rupture on the SW segment of the EAF starts after rupture onset on its NE segment: the SW rupture is triggered by the NE rupture. Only when the EAF has initial stresses very close to failure can its SW segment be directly triggered by the initial splay-fault rupture, earlier than the activation of the NE segment. These results advance our understanding of the mechanisms of multi-segment rupture and the complexity of rupture processes, paving the way for a more accurate assessment of earthquake hazards.
MOBA: Monopoli Bahasa Arab Sebagai Media Pembelajaran Upaya Meningkatkan Semangat Anak Sekolah Dasar dalam Menghafal Al-Qur’an di Era Revolusi Industri 4.0
Authors: Iskandar Wahyuni , Ya'kub Ya'kub , Rahman Abd. 
Published: November 2023

Bahasa diciptakan untuk manusia dan kemanusiaan, maka sangatlah penting bagi umat memahami dan menguasai bahasa Arab. Pemerolehan bahasa merupakan salah satu aspek akulturasi serta tingkat pengakulturasian seseorang pada kelompok bahasa tertentu dalam memperoleh bahasa lainnya atau yang dimaksud bahasa kedua atau bahasa asing sebagai alat komunikasi Sehingga MOBA (Monopoli Bahasa Arab) ini dapat dijadikan sebagai media pembelajaran untuk pengenalan dan penanaman bahasa Arab sejak usia sekolah dasar. Karya Tulis Ilmiah ini bertujuan untuk mengetahui konsep dan manfaat MOBA (Monopoli Bahasa Arab), sebagai media untuk membantu pemerintah, masyarakat untuk mengajarkan anak mengenai bahasa Arab dasar yaitu kosa kata Arab pada anak sekolah dasar. Jenis penelitian yang digunakan yaitu pustaka (library research) dengan pendekatan kualitatif deskriptif. MOBA (Monopoli Bahasa Arab) merupakan salah satu media pembelajaran yang menyerupai monopoli namun dibuat semenarik mungkin dalam bentuk kosa kata. Manfaat MOBA yaitu untuk meningkatkan minat belajar kosa kata hingga ayat al-Qur’an terhadap anak sekolah dasar. Sehingga dapat disimpulkan bahwa pentinya bahasa arab dapat direalisasikan menggunakan MOBA (Monopoli Bahasa Arab) sebagai media pembelajaran upaya meningkatkan kosa kata bahasa arab pada anak sekolah dasar di era revolusi industri 4.0Kata Kunci: Anak Sekolah Dasar, Media Pembelajaran, MOBA (Monopoli Bahasa Arab), Revolusi Industri 4.0
ANALISIS HASIL BELAJAR MAHASISWA PENDIDIKAN BAHASA ARAB UNIVERSITAS MUHAMMADIYAH SETELAH TERINTEGRASI DENGAN MA’HAD AL-BIRR
Authors: Nadila Andi , Masnan Sulaeman , Masnan Sulaeman , Amin Nur Fadilah , Amin Nur Fadilah 
Published: November 2023

AbstractThis study aims to determine (1). learning outcomes and (2). factors that influence student learning outcomes in the Arabic Language Education Study Program, Faculty of Islamic Religion, University of Muhammadiyah Makassar, for the 2021/2022 Academic Year after being integrated with Ma'had Al-Birr. Techniques to collect data in the form of interviews and documentation. Data analysis techniques include data reduction, data presentation and data verification. The data sources in this study were students for the 2021/2022 academic year and permanent lecturers of Arabic language education study programs as well as written sources, namely grade transcripts and student cumulative grade point averages or GPA.The results of this study show that: (1) Student learning outcomes that focus on the cumulative grade point average or GPA. Of the 86 active students of the Arabic language education study program for the 2021/2022 academic year, 50% of students have high GPA, 40.70% of students have medium GPA and 9.30% of students have low GPA. (2) The factors that influence student learning outcomes are divided into two:First,Internal factors, students' interest in learning Arabic and previous educational background are very influential.Second,external factors, motivation to learn from the family and friendship environment as well as the university's assessment system which has high standards.Keywords : Student Learning Outcomes, Arabic AbstrakPenelitian ini bertujuan untuk mengetahui (1). hasil belajar dan (2). faktor-faktor yang mempengaruhi hasil belajar Mahasiswa Program Studi Pendidikan Bahasa Arab Fakultas Agama Islam Universitas Muhammadiyah Makassar Tahun Akademik 2021/2022 setelah Terintegrasi dengan Ma’had Al-Birr. Teknik mengumpulan data berupa wawancara dan dokumentasi. Teknik analisis data meliputi, reduksi data, penyajian data dan verifikasi data. Adapun sumber data dalam penelitian ini adalah mahasiswa tahun akademik 2021/2022 dan dosen tetap prodi pendidikan bahasa Arab serta sumber tertulis yaitu transkip nilai dan Indeks prestasi kumulatif mahasiswa atau IPK.Hasil penelitian ini menunjukan bahwa: (1) Hasil belajar mahasiswa yang berfokus pada indeks prestasi kumulatif atau IPK. Dari 86 mahasiswa aktif prodi pendidikan bahasa Arab tahun akademik 2021/2022 terdapat 50% mahasiswa yang memiliki IPK tinggi, 40,70% mahasiswa yang memiliki IPK sedang dan 9,30% mahasiswa yang memiliki IPK rendah. (2) Faktor-faktor yang mempengaruhi hasil belajar mahasiswa terbagi menjadi dua: Pertama, faktor internal, minat belajar bahasa Arab mahasiswa dan latar belakang pendidikan sebelumnya sangat berpengaruh. Kedua, faktor eksternal, motivasi belajar dari lingkungan keluarga dan pertemanan serta sistem penilaian Universitas yang memiliki standar tinggi.Kata Kunci : Hasil Belajar Mahasiswa, Bahasa Arab
PENGARUH GURU PENDIDIKAN ISLAM DALAM MEMBANGUN KESEHATAN MENTAL BELAJAR SISWA
Authors: Pratama Sandi , Alamsyah Alamsyah 
Published: November 2023

Pembinaan mental merupakan suatu aktivitas yang sangat penting dan merupakan suatu keharusan serta merupakan sebagaian dari kehidupan pribadi manusia. Sikap dan tindakan manusia dalam hidupnya yang tak merupakan pantulan kepribadiannya yang tumbuh dan berkembang sejak lahir bahkan ketika masih dalam kandungan. Pendidikan Agama hendaknya dapat mewarnai kepribadian anak, sehingga agama itu benar-benar menjadi bagian dari pribadinya yang akan menjadi pengendali dalam hidupnya dikemudian hari.. SMP Muhammadiyah 1 Makassar dalam pembinaan mental mempunyai cara maupun tekhnik dalam membangun mental tersebut. Adapun upaya yang dilakukan oleh guru PAI adalah sebagai berikut :Melalui kegiatan pembelajaran dan Pembinaan di Muhsollah Adapun faktor penghambat Guru PAI SMP Muhammadiyah 1 Makassar dalam membangun kesehatan mental siswa adalah pengaruh keluarga dan pengaruh pergaulan. Guru pendidikan agama islam mempunyai pengaruh dalam pembinaan mental siswa karena selain mengajarkan ilmu pengetahuan, guru pendidikan agama islam juga mengajarkan/penanaman nilai-nilai agama.t.