bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of emotional solidarity–driven tourists’ nostalgia in shaping advocacy intentions
Authors: Razzaq Sadaf , Akhtar Naeem 
Published: February 2024

PurposeExamining emotional solidarity that drives tourists’ nostalgia has received significant attention, offering valuable insights that can aid in the selection of a travel destination. However, tourists’ nostalgia, along with its antecedents—perceived safety risk and emotional solidarity, has gained less attention within the setting of Pakistan. Therefore, this research has been carried out and validated a research framework using the stimulus-organism-response model to investigate the links between perceived safety risk, emotional solidarity—welcoming nature, emotional closeness, sympathetic understanding, perceived nostalgia, and destination advocacy intentions. In addition, this model employed destination attachment—place identity and place dependence—as a boundary condition on the relationships between emotional solidarity and advocacy intentions.Design/methodology/approachThis study collected 545 responses through two methods: offline distribution of print copies of the questionnaire and online surveys from domestic tourists who visited scenic destinations last year. Structural equation modeling (SEM) was performed using AMOS 26, and the PROCESS macro was conducted using IBM SPSS 28.FindingsThe findings highlighted that perceived safety risk negatively influences emotional solidarity—welcoming nature, emotional closeness, sympathetic understanding—, resulting in a positive effect on perceived nostalgia. Furthermore, tourists’ perceived nostalgia positively triggers advocacy intentions. The findings also confirmed the boundary conditions of destination attachment—place identity and place dependence—on the association between emotional solidarity and perceived nostalgia.Practical implicationsThree major practical implications of these findings: First, ensuring visitor safety with smart security measures, digital tools for quick response, and local community involvement. Second, highlighting local markets, art, and architecture to enrich cultural experiences and promote accessibility and diversity. Finally, using marketing to generate nostalgic experiences through local collaborations, professional storytelling, and engaging social media content to build emotional ties and curiosity.Originality/valueIn terms of originality, this is pioneering research intended at developing and validating the model in the context of Pakistani destinations. Furthermore, this marks the initial step in examining the proposed relationships between perceived safety risk and emotional solidarity in fostering tourists' perceived nostalgia, ultimately leading to a strong desire to advocate for the destination.
Evolving a conceptual framework for sustainable e-waste management: a consumer typology based on environmental behavior
Authors: Vighnesh Nanjangud Vishwanath , Patil Balachandra , Chandrashekar Deepak 
Published: February 2024

Purpose
There is widespread consensus that unchecked growth of e-waste is a major challenge to global sustainability transition. Current research has failed to connect e-waste with principles of circularity and sustainability from the consumption perspective. This paper aims to answer the following questions: What kind of environmental behaviors (EBs) exist among consumers in relation to e-waste?; In what ways are these consumers different from and similar to each other based on their EBs in relation to e-waste?; How do consumers and their EBs contribute to sustainable waste management?

Design/methodology/approach
Based on primary data from an Indian sample of information and communication technology consumers, EBs relevant to e-waste management are identified. In the next stage, a behavior-based segmentation and profiling of consumers is performed.

Findings
The first phase of analysis produced eight distinct EBs which were then used in the next phase to obtain a consumer typology of three segments. The three consumer segments differed significantly with each other on general environmental behavior and awareness about e-waste.

Research limitations/implications
The paper develops a comprehensive conceptual framework for studying the demand-side circularity transition for sustainable e-waste management.

Practical implications
For business stakeholders, findings of the study and the proposed framework can inform behavior change interventions to customize offerings for different right consumer segments.

Originality/value
The paper adds new knowledge to the intersectional area of e-waste, consumer behavior and sustainability through the development of consumer typology and a conceptual framework.
Exploring workplace learning experience in work transition among K-12 teachers during COVID-19
Authors: Niu Yuanlu 
Published: February 2024

Purpose
When the emergency transition started in the spring of 2020 in the USA, teachers had to quickly switch from traditional in-person teaching to distance and remote teaching, regardless of their level of preparation. The distance and remote learning environments and contexts were different from traditional classrooms, which significantly changed the way teachers communicated and engaged with students in learning. The purpose of this study was to explore the workplace learning experience of K-12 educators during their work transition due to the COVID-19 pandemic in the USA.

Design/methodology/approach
In total, 30 qualitative, in-depth, semi-structured, one-on-one interviews were conducted with K-12 educators in Arkansas in the USA and synthesized their experiences.

Findings
This study identified four major themes in the workplace learning experiences of K-12 teachers during the COVID-19 pandemic: major challenges in workplace learning, including limited time, information overload, lack of relevance and customization and balancing priorities; challenges specific to different subgroups, such as age differences, prior experience and access to technology; strategies of workplace learning, notably collaborative learning, on-the-job training and professional development; and support for workplace learning, encompassing both formal support from schools and districts and informal support from family, friends and peers.

Originality/value
The paper provides original insights into K-12 teachers’ workplace learning during the COVID-19 pandemic by understanding their adaptation strategies. It fills a research gap by highlighting both the challenges and support mechanisms in educational transitions during a crisis.
Local business environment and firm innovation: evidence from China
Authors: Wu Jiapeng , Gao Dayu , Xu Cheng , Sun Yanqi 
Published: February 2024

PurposeThis paper aims to investigate the influence of the regional business environment on local firm innovation, considering various dimensions such as administrative, financial and legal environments.Design/methodology/approachMultiple regression analysis is employed to analyze archival data for firms listed on Chinese stock markets.FindingsWe find that the optimizations of the administrative and financial environments positively affect firm innovation, whereas the legal environment does not exert a similar impact. Our analysis also reveals that the business environment’s optimization significantly influences innovation in firms that are small, non-state-owned and operating in high-tech industries. Furthermore, the business environment acts as a moderating variable in the relationship between firm innovation and firm value.Research limitations/implicationsThis study contributes to a more comprehensive understanding of institutional-level determinants of firm innovation, highlighting the nuances of the legal environment and the importance of context-specific analysis, especially in emerging markets like China.Practical implicationsDeveloping countries can significantly enhance firm innovation by improving the business environment, including the optimization of administrative and financial systems, reducing transaction costs and ensuring capital supply. Tailored legal frameworks and alternative institutional strategies may also be explored.Social implicationsThis study explicitly emphasizes the governmental role in promoting firm innovation, shedding light on policy formulation and strategic alignment with local administrative policies.Originality/valueTo the best of our knowledge, this paper is the first to explore the relationship between the business environment and firm innovation using World Bank indicators in an emerging market context, providing novel insights into the unique dynamics of legal, financial and administrative sub-environments.
Archaeal blooms and busts in an estuarine time series
Authors: Guider Justin T. , Yoshimura Kristin M. , Block Kaleigh R. , Biddle Jennifer F. , Shah Walter Sunita R. 
Published: February 2024

AbstractCoastal bays, such as Delaware Bay, are highly productive, ecologically important transitions between rivers and the coastal ocean. They offer opportunities to investigate archaeal assemblages across seasons, with the exchange of water masses that occurs with tidal cycles, and in the context of variable organic matter quality. For a year‐long estuarine, size‐fractionated time series, we used amplicon sequencing, chemical measurements, and qPCR to follow archaeal groups through the seasons. We detected seasonally high abundances of Marine Group II archaea in summer months which correlate with indicators of phytoplankton production, although not phytoplankton biomass. Although previous studies have reported associations between Marine Group II archaea and particles, here they are almost entirely found in very small particles (0.22–0.7 μm), suggesting they are free‐living cells. Populations of Nitrososphaeria did not vary with particle size or environmental conditions. Methanogens were significant fractions of archaeal sequences in large particles at low tide during winter months. Contrary to expectations, Nanoarchaeia were found predominantly in the free‐living fraction despite the previous observation that they require an association with hosts. These results underscore the utility of time series studies in shallow, tidally mixed estuarine environments that capture variable conditions for understanding the ecology and biogeochemistry of planktic archaea.
Microglia activity in the human basal ganglia is altered in alcohol use disorder and reversed with remission from alcohol
Authors: Rasool Ameer Elena , Furlong Teri , Prasad Asheeta A. 
Published: February 2024

AbstractAlcohol use disorder (AUD) is characterized by cycles of abuse, withdrawal, and relapse. Neuroadaptations in the basal ganglia are observed in AUD; specifically in the putamen, globus pallidus (GP), and ventral pallidum (VP). These regions are associated with habit formation, drug‐seeking behaviors, and reward processing. While previous studies have shown the crucial role of glial cells in drug seeking, it remains unknown whether glial cells in the basal ganglia are altered in AUD. Glial cells in the putamen, GP, and VP were examined in human post‐mortem tissue of AUD and alcohol remission cases. Immunohistochemistry was performed to analyze cell count, staining intensity, and morphology of microglia and astrocytes, using markers Iba‐1 and GFAP. Morphological analysis revealed a significant decrease in microglia cell size and process retraction, indicating activation or a dystrophic microglia phenotype in individuals with AUD compared to controls. Microglia staining intensity was also higher in the GP and VP in AUD cases, whereas microglia staining intensity and cell size in remission cases were not different to control cases. In contrast, no astrocyte changes were observed in examined brain regions for both AUD and remission cases compared to controls. These results suggest alcohol exposure alters microglia, potentially contributing to dysfunctions in the basal ganglia that maintain addiction, and abstinence from alcohol may reverse microglia changes and associated dysfunctions. Overall, this study further characterizes AUD neuropathology and implicates microglia in the putamen, GP, and VP as a potential target for therapy.
Effect of implant type on the stability of cantilever fixed dental prostheses: An in vitro study
Authors: Rohr Nadja , Karakas‐Stupar Irina , Karlin Sabrina , Zitzmann Nicola U. , Zaugg Lucia K. 
Published: February 2024

AbstractObjectivesTo simulate the replacement of a premolar with an implant‐supported cantilever fixed dental prosthesis (ICFDP) and how the fracture load is affected by implant type, positioning within the zirconia blank, and aging protocol.Materials and MethodsSeventy‐two ICFDPs were designed either within the enamel‐ or dentin layer of a 4Y‐PSZ blank for bone‐level and tissue‐level titanium‐zirconium implants. Fracture load was obtained on the cantilever at baseline (no aging) or after aging in a chewing simulator with the load applied within the implant axis (axial aging) or on the cantilever (12 groups with n = 6). A three‐way ANOVA was applied (α = .05).ResultsA three‐way ANOVA revealed a significant effect on fracture load values of implant type (p = .006) and aging (p < .001) but not for the position within the zirconia blank (p = .847). Fracture load values significantly increased from baseline bone level (608 ± 118 N) and tissue level (880 ± 293 N) when the implants were aged axially, with higher values for tissue level (1065 ± 182 N) than bone level (797 ± 113 N) (p < .001). However, when the force was applied to the cantilever, fracture load values decreased significantly for tissue‐level (493 ± 70 N), while values for bone‐level implants remained stable (690 ± 135 N).ConclusionsFor ICFDPs, the use of bone‐level implants is reasonable as catastrophic failures are likely to be restricted to the restoration, whereas with tissue‐level implants, the transmucosal portion of the implant is susceptible to deformation, making repair more difficult.
Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function
Authors: Xu Fuyi , Chen Anran , Pan Shuijing , Wu Yingying , He Hongjie , Han Zhe , Lu Lu , Orgil Buyan‐Ochir , Chi XiaoDong , Yang Cunhua , Jia Shushan , Yu Cuicui , Mi Jia 
Published: February 2024

AbstractBackgroundThere is growing evidence of a strong correlation between pain sensitivity and cognitive function under both physiological and pathological conditions. However, the detailed mechanisms remain largely unknown. In the current study, we sought to explore candidate genes and common molecular mechanisms underlying pain sensitivity and cognitive function with a transcriptome‐wide association study using recombinant inbred mice from the BXD family.MethodsThe pain sensitivity determined by Hargreaves' paw withdrawal test and cognition‐related phenotypes were systematically analyzed in 60 strains of BXD mice and correlated with hippocampus transcriptomes, followed by quantitative trait locus (QTL) mapping and systems genetics analysis.ResultsThe pain sensitivity showed significant variability across the BXD strains and co‐varies with cognitive traits. Pain sensitivity correlated hippocampual genes showed a significant involvement in cognition‐related pathways, including glutamatergic synapse, and PI3K‐Akt signaling pathway. Moreover, QTL mapping identified a genomic region on chromosome 4, potentially regulating the variation of pain sensitivity. Integrative analysis of expression QTL mapping, correlation analysis, and Bayesian network modeling identified Ring finger protein 20 (Rnf20) as the best candidate. Further pathway analysis indicated that Rnf20 may regulate the expression of pain sensitivity and cognitive function through the PI3K‐Akt signaling pathway, particularly through interactions with genes Ppp2r2b, Ppp2r5c, Col9a3, Met, Rps6, Tnc, and Kras.ConclusionsOur study demonstrated that pain sensitivity is associated with genetic background and Rnf20‐mediated PI3K‐Akt signaling may involve in the regulation of pain sensitivity and cognitive functions.
Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model
Authors: Horska Katerina , Skrede Silje , Kucera Jan , Kuzminova Gabriela , Suchy Pavel , Micale Vincenzo , Ruda‐Kucerova Jana 
Published: February 2024

AbstractAimWidely used second‐generation antipsychotics are associated with adverse metabolic effects, contributing to increased cardiovascular mortality. To develop strategies to prevent or treat adverse metabolic effects, preclinical models have a clear role in uncovering underlying molecular mechanisms. However, with few exceptions, preclinical studies have been performed in healthy animals, neglecting the contribution of dysmetabolic features inherent to psychotic disorders.MethodsIn this study, methylazoxymethanol acetate (MAM) was prenatally administered to pregnant Sprague–Dawley rats at gestational day 17 to induce a well‐validated neurodevelopmental model of schizophrenia mimicking its assumed pathogenesis with persistent phenotype. Against this background, the dysmetabolic effects of acute treatment with olanzapine and haloperidol were examined in female rats.ResultsPrenatally MAM‐exposed animals exhibited several metabolic features, including lipid disturbances. Half of the MAM rats exposed to olanzapine had pronounced serum lipid profile alteration compared to non‐MAM controls, interpreted as a reflection of a delicate MAM‐induced metabolic balance disrupted by olanzapine. In accordance with the drugs' clinical metabolic profiles, olanzapine‐associated dysmetabolic effects were more pronounced than haloperidol‐associated dysmetabolic effects in non‐MAM rats and rats exposed to MAM.ConclusionOur results demonstrate metabolic vulnerability in female prenatally MAM‐exposed rats, indicating that findings from healthy animals likely provide an underestimated impression of metabolic dysfunction associated with antipsychotics. In the context of metabolic disturbances, neurodevelopmental models possess a relevant background, and the search for adequate animal models should receive more attention within the field of experimental psychopharmacology.
Inter‐relationships between cardiovascular, renal and metabolic diseases: Underlying evidence and implications for integrated interdisciplinary care and management
Authors: Vora Jiten , Cherney David , Kosiborod Mikhail N. , Spaak Jonas , Kanumilli Naresh , Khunti Kamlesh , Lam Carolyn S. P. , Bachmann Michael , Fenici Peter ,   the CaReMe Global Alliance
Published: February 2024

AbstractCardiovascular, renal and metabolic (CaReMe) diseases are individually among the leading global causes of death, and each is associated with substantial morbidity and mortality. However, as these conditions commonly coexist in the same patient, the individual risk of mortality and morbidity is further compounded, leading to a considerable healthcare burden. A number of pathophysiological pathways are common to diseases of the CaReMe spectrum, including neurohormonal dysfunction, visceral adiposity and insulin resistance, oxidative stress and systemic inflammation. Because of the shared pathology and common co‐occurrence of the CaReMe diseases, the value of managing these conditions holistically is increasingly being realized. A number of pharmacological and non‐pharmacological approaches have been shown to offer simultaneous metabolic, cardioprotective and renoprotective benefits, leading to improved patient outcomes across the CaReMe spectrum. In addition, increasing value is being placed on interdisciplinary team‐based and coordinated care models built on greater integration between specialties to increase the rate of early diagnosis and adherence to practice guidelines, and improve clinical outcomes. This interdisciplinary approach also facilitates integration between primary and specialty care, improving the patient experience, optimizing resources, and leading to efficiencies and cost savings. As the burden of CaReMe diseases continues to increase, implementation of innovative and integrated care delivery models will be essential to achieve effective and efficient chronic disease management and to ensure that patients benefit from the best care available across all three disciplines.
IDegLira for the real‐world treatment of type 2 diabetes in Italy. Final results from the REX observational study
Authors: Fadini Gian Paolo , Buzzetti Raffaella , Pitocco Dario , Tortato Elena , Scatena Alessia , Lamacchia Olga , Lastoria Giusi , Simoni Lucia , Consoli Agostino ,   REX study group
Published: February 2024

AbstractAimThe study was designed to generate real‐world evidence on IDegLira in the Italian clinical practice in two groups of patients with type 2 diabetes (T2D), switching to IDegLira either from a basal only (basal group) or basal‐bolus insulin regimen (BB group).Materials and MethodsThis was a non‐interventional, multicentre, single‐cohort, prospective study assessing the long‐term glycaemic control in patients with T2D, who switched to IDegLira from a basal insulin ± glucose‐lowering medication regimen with or without a bolus insulin component for approximately 18 months, conducted in 28 Italian diabetes centres. The primary endpoint was the change in glycated haemoglobin (HbA1c) levels from baseline to 6 months after IDegLira initiation.ResultsThe study included 358 patients with a mean age 67.2 years and diabetes duration of 15.7 years. HbA1c significantly decreased from IDegLira start to all study time points in the overall population (basal group −1.19%; BB group −0.60% at the end of observation). Patients achieving HbA1c <7% levels increased from 12.9% (n = 43) to 40.3% (n = 110) at 18 months. Fasting blood glucose and body weight also significantly decreased in both groups, although more in the BB group. Overall, 14.3% of completed patients had an intensification of treatment (mainly in the basal group) and 48.6% had a simplification of treatment (mainly in the BB group).ConclusionsSwitching to IDegLira in a real‐world clinical setting is a valid therapeutic option for patients with T2D with inadequate glycaemic control on basal or BB insulin regimen and/or need to simplify their insulin therapy, with specific reasons and therapeutic goals according to different T2D management trajectories.
On the inefficiency of non‐competes in low‐wage labour markets
Authors: Potter Tristan , Hobijn Bart , Kurmann André 
Published: February 2024

We study the efficiency of non‐compete agreements (NCAs) in an equilibrium model of labour turnover. The model is consistent with empirical studies showing that NCAs reduce turnover and average wages for low‐wage workers. The model also predicts that, by reducing turnover, NCAs raise recruitment and employment. We show that optimal NCA policy: (i) is characterized by a Hosios‐like condition that balances the benefits of higher employment against the costs of inefficient congestion and poaching; (ii) depends critically on the minimum wage; and (iii) alone cannot always achieve the constrained‐efficient allocation—a result that also holds for optimal minimum wage policy—yet with both policies, efficiency is always attainable. To guide policymakers, we derive a sufficient statistic in the form of an easily computed employment threshold above which NCAs are necessarily inefficiently restrictive, and show that employment levels in current low‐wage US labour markets typically exceed this threshold. Finally, we calibrate the model and show that Oregon's 2008 NCA ban for low‐wage workers increased welfare modestly (by roughly 0.1%), and that if policymakers had also raised the minimum wage to its optimal level conditional on the enacted NCA ban (a 30% increase), then welfare would have increased more substantially—by over 1%.