bluuebunny/crossref_metadata_2025_split huggingface dataset:
A molecularly imprinted polymer for the efficient adsorption of morphine
Authors: Ku Chenfeng , Zhang Youhong , Zhou Guohong , Wang Kean 
Published: November 2023

AbstractMolecularly imprinted polymers (MIPs) were synthesized via the precipitation polymerization technology for the specific adsorption of morphine. A number of polymers (methacrylic acid, trifluoromethyl acrylic acid, and acrylamide) were studied, respectively, as the precursor monomers under various synthetic conditions (the imprinting (IP) ratio, cross‐linking (CL) ratio, solvent ratio, reaction temperature, etc.). The MIP with optimal performance was derived using methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinker, and azobisisobutyronitrile (AIBN) as the initiator, with an IP ratio of 1:3 and a CL ratio of 5:1. This MIP presented a maximum morphine adsorption capacity of 38.24 mg/g (one of the highest capacities ever reported in the literature) at a bulk morphine concentration of ~230 ppm in acetonitrile solution. The adsorption capacity, selectivity, reusability, as well as the chemical and mechanical stabilities of the MIP were confirmed by the adsorption experiments, instrumental characterization, thermodynamic analysis, as well as the proposed mechanisms.
The devil is in the details: Advancing our collective understanding of naturalistic developmental behavioral interventions
Authors: Shire Stephanie 
Published: November 2023

AbstractGiven the growing body of randomized trials examining various Naturalistic Developmental Behavioral Intervention (NDBI) approaches, a dialog has emerged exploring the overlap in strategies across NDBIs to create single measures that propose to capture core strategies across the interventions. This commentary will ask readers to consider the current state of the science, the potential value of looking not only for similarities but also for differences across approaches, and present five scientific next steps to advance our collective understanding of the NDBIs including: (a) operationalizing intervention strategies and outcomes, (b) expansion of the effectiveness evidence base and begin testing implementation strategies for individual NDBIs, (c) rigorous testing of core intervention components and the mechanism of each intervention, (d) personalization, and (e) supporting transparency with a priori trial registration.
Hysteroscopic resection as a safe minimally invasive technique for the management of cornual pregnancy: A case report and literature review
Authors: Tsagias Nikolaos , Xydias Emmanouil M. , Ziogas Apostolos C. , Tsikouras Panagiotis , Patsinakidis Nikolaos , Daniilidis Angelos , Tsakos Elias 
Published: November 2023

Key Clinical MessageHysteroscopic resection of ectopic cornual pregnancy following MRI imaging is a safe and effective treatment option without significantly impacting fertility potential or increasing the risk of future obstetrical complications.
Electrodeposition Parameters Dramatically Influence the Morphology, Stability, and Performance of n‐Si/Pt Light‐Addressable Electrochemical Sensors
Authors: Hernandez Jocelyn B. , Epright Zackary D. , Terrero Rodríguez Irina M. , O'Neil Glen D. 
Published: November 2023

AbstractLight addressable electrochemical (LAE) sensors have seen great utility in the past several years because they enable multiple localized electrochemical measurements to be performed on a single macroscopic electrode, opening up applications in imaging, biosensing, surface patterning, and multiplexing. In this study, we investigated the effects of electrodeposition on the formation of LAE sensors formed between n‐Si and electrodeposited Pt. We prepared sensors by electrodepositing Pt onto freshly‐etched n‐Si under a variety of conditions, varying the Pt precursor concentration, electrodeposition time, supporting electrolyte, and potential waveform. We characterized the sensors using a combination of atomic force microscopy, electrochemical impedance spectroscopy, and cyclic voltammetry. This study shows that the electrodeposition parameters have a dramatic impact on the morphology of the electrodeposited surfaces, sensor stability, and sensitivity towards H2O2. Specifically, we observed that continuous Pt films prepared with a higher Pt precursor concentration were more stable and had better linearity, higher sensitivity, and broader dynamic range than those prepared with a lower Pt precursor concentration. The stability and increased H2O2 sensing performance correlate strongly with an increase in the Pt islands which make up the film. These data highlight that the morphology of the metal in semiconductor/metal junction LAE sensors has an impact on important performance metrics like stability and sensitivity. They also demonstrate the need for semiconductor/metal LAE sensors to be studied using micro‐ and nanoscale imaging techniques in order to more deeply understand their performance characteristics.
Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems
Authors: Siedentop Regine , Prenzel Tobias , Waldvogel Siegfried R. , Rosenthal Katrin , Lütz Stephan 
Published: November 2023

AbstractInvited for this issue's Front Cover are the group of Bioprocess Engineering at TU Dortmund University, Department of Chemistry at Johannes Gutenberg University Mainz, and the Biotechnology Group at Constructor University. The front cover illustrates the electroenzymatic regeneration of ATP. The electrons of an enzymatically catalyzed redox reaction necessary for the ATP regeneration cascade are transferred to an electrode mediated by ferrocenyl‐methanol. Regenerative and green energy can therefore be used to drive the reaction. Cover design by Tobias Prenzel and Finn Moeller. Read the full text of the Research Article at 10.1002/celc.202300332.
Pretreatment albumin is a prognostic and predictive biomarker for response to atezolizumab across solid tumors
Authors: Saal Jonas , Ellinger Jörg , Ritter Manuel , Brossart Peter , Hölzel Michael , Klümper Niklas , Bald Tobias 
Published: November 2023

AbstractObjectivesReliable predictive biomarkers for response to immune checkpoint inhibition (ICI) are lacking. Pretreatment serum albumin, a known prognostic and predictive factor in ICI‐treated patients, has been proposed as a potential pharmacokinetic surrogate marker for anti‐PD1/PD‐L1 antibodies, as it shares a homeostatic pathway with IgG. However, this hypothesis is currently based on theoretical considerations and limited evidence from retrospective data. Therefore, we comprehensively investigated the prognostic and predictive value of pretreatment albumin and its relationship with anti‐PD‐L1 IgG levels.MethodsWe analysed pretreatment albumin and atezolizumab serum levels and clinical response in four trials (IMvigor210, IMvigor211, IMmotion151 and OAK) of patients with metastatic lung‐, renal‐ or urothelial cancer who received atezolizumab alone or in combination.ResultsA total of 3391 patients were analysed. Correlation between serum albumin and atezolizumab levels was weak (Pearson's coefficient 0.23). We found a strong prognostic value for pretreatment serum albumin across all trials. Both atezolizumab serum levels and serum albumin were independently correlated with overall survival. Importantly, in the three randomised phase III clinical trials, the survival benefit for immunotherapy compared with the active comparator arm was limited to patients with pretreatment serum albumin > 35 g L−1.ConclusionOur data do not support the hypothesis that albumin serves as a surrogate for atezolizumab pharmacokinetics. However, we show that albumin on its own exerts strong prognostic value for patients treated with immunotherapy. As benefit from immunotherapy was limited to patients with normal/elevated serum albumin levels, baseline albumin could potentially be used as a predictive marker for immune checkpoint inhibition.
Alternative lifestyles: A plague persistence hypothesis
Authors: Wimsatt Jeffrey , Eads David A. , Matchett Marc R. , Biggins Dean E. 
Published: November 2023

AbstractSeveral explanations have been posited for how the plague bacterium (Yersinia pestis) reemerges during sylvatic cycles within the same foci over many years, and often without direct evidence of host die‐offs. One prevalent view is that transmission‐optimized Y. pestis bacteria, exhibiting epizootic/enzootic behavior, almost continually replicate and survive through repeated, linked, host‐centered propagation events. These bacteria, we will refer to as “r‐pestis” type ecotype(s), represent a limited number of phenotypic lineages exhibiting optimal transmissibility and high rates of reproduction. These attributes, it is thought, assure their durability through time. For continuous r‐pestis type expansions to be successful, adequate numbers of fleas and hosts must become infected to produce massive numbers of bacteria. In the process, host and flea numbers decline as they succumb to plague. Here we hypothesize that r‐pestis population expansions seed the environment and confront a unique, highly competitive local milieu, where natural selection favors new ecotypes that incorporate a range of emergent adaptive survival strategies. These newly adapted survivors we recognize as a range of “K‐pestis” ecotypes with greater durability and lower reproduction rates. These emergent K‐pestis forms may arise in succession or coexist for varying periods of time with r‐pestis ecotypes, and with other K‐pestis ecotypes. Among K‐pestis ecotypes, we hypothesize that through adaptive radiations, some persist within flea life stages, soil, organic waste, amoebae, plants, carcasses, hosts, or within niches yet to be characterized. In some settings, after a long quiet period, when favorable, K‐pestis bacteria may trigger a singular event where an r‐pestis transmission stream emerges precipitating another enzootic/epizootic progression. If this hypothesis withstands rigorous testing, then Y. pestis might represent an even more formidable, enduring, and adaptable foe, where unforeseen local events could trigger new epidemic and epizootic/enzootic events threatening humans and populations of other mammals, including those of conservation concern.
Torsional vibration characteristics analysis and adaptive fixed‐time control of wind turbine drivetrain
Authors: Yang Jianxiang , Zhou Feihang , Xiong Jianbin , Hou Zhicheng , Zhang Jinliang , Mu Anle 
Published: November 2023

AbstractThe drivetrain has an important impact on the stability and reliability of wind turbines operating in complex conditions, which belongs to the electromechanical coupling system. This work studies the two domains of research on drivetrain vibration analysis and control method in detail. The electromechanically coupled torsional vibration model is first established by considering the air gap magnetic field energy of the PMSG. Preliminary analysis in terms of Hamiltonian energy indicates that there is sufficient energy to sustain the exciting oscillation behaviors. Moreover, to reduce the vibration amplitude caused by wind speed or torsional stiffness, a novel adaptive fixed‐time control method is proposed to solve the issue of wind turbine drivetrain chaotic oscillation with uncertainties and disturbances. Furthermore, the proposed method not only can prevent the jumping and bifurcation of torsional vibration from happening, but also there are the advantages of the control scheme with high accuracy, fast convergence rate and strong robustness. For the fair comparison, three different control methods have been used to demonstrate the superiority of the control scheme by the simulation results. The research results can provide a theoretical basis for the parameter design and control of wind turbine drivetrain.
Maize seeds forecasting with hybrid directional and bi‐directional long short‐term memory models
Authors: Isik Hakan , Tasdemir Sakir , Taspinar Yavuz Selim , Kursun Ramazan , Cinar Ilkay , Yasar Ali , Yasin Elham Tahsin , Koklu Murat 
Published: November 2023

AbstractThe purity of the seeds is one of the important factors that increase the yield. For this reason, the classification of maize cultivars constitutes a significant problem. Within the scope of this study, six different classification models were designed to solve this problem. A special dataset was created to be used in the models designed for the study. The dataset contains a total of 14,469 images in four classes. Images belong to four different maize types, BT6470, CALIPOS, ES_ARMANDI, and HIVA, taken from the BIOTEK company. AlexNet and ResNet50 architectures, with the transfer learning method, were used in the models created for the image classification. In order to improve the classification success, LSTM (Directional Long Short‐Term Memory) and BiLSTM (Bi‐directional Long Short‐Term Memory) algorithms and AlexNet and ResNet50 architectures were hybridized. As a result of the classifications, the highest classification success was obtained from the ResNet50+BiLSTM model with 98.10%.
Peripheral edema associated with antidepressant use: Systematic review of case reports
Authors: Joseph Jithin T. , Vishwanath Rashmi , Praharaj Samir Kumar 
Published: November 2023

AbstractBackgroundOedema associated with psychotropics can impose a considerable burden, leading to increased morbidity and cost. Peripheral oedema is sometimes related to the use of antidepressants, which are among the most prescribed psychotropic medications. We reviewed the reported cases of antidepressant‐associated oedema to understand the risk factors, aetiology and outcome.MethodsWe searched the Medline, Web of Science and Embase databases to identify reported cases of peripheral oedema associated with antidepressant use. We included studies published in English and those with full‐text availability. A systematic review of the reports was done to identify the antidepressants associated with oedema, explore possible risk factors, investigate potential mechanisms, and assess the outcome.ResultsWe identified a total of 45 cases (27 case reports and five case series) that reported oedema associated with antidepressant use. Almost all major classes of antidepressants were found to be associated with oedema. Among these drugs, trazodone, mirtazapine, and escitalopram were the most implicated. Older age and female gender were more commonly associated with oedema. Etiologically, antagonism of α1 adrenergic receptors and 5HT2A receptors, leading to vasodilation and oedema, emerged as the most prevalent mechanisms. In most cases, the oedema subsided following the discontinuation of the antidepressants.ConclusionsPeripheral oedema associated with antidepressant use can represent a significant adverse drug reaction involving various classes of antidepressants. To ensure timely identification and proper management of oedema, regular monitoring is crucial.
A person‐centered approach in developmental science: Why this is the future and how to get there
Authors: van der Gaag Mandy A. E. 
Published: November 2023

AbstractThis paper argues for a person‐centered approach in developmental science and presents theoretical and empirical techniques to help shift the focus to the individual. The need for a person‐centered approach is urgent, because of widespread nonergodicity in developmental psychology: traditional between‐individual, group‐level statistics often cannot be used to understand individuals over time. Evidence for nonergodicity has been gathered in domains such as personality, emotions, identity, performance and intelligence. This highlights a mismatch between our typical research methods—group‐level analyses—and a core aim of developmental science: understanding the development of individuals. The implications are profound. Without insights into within‐individual processes, our understanding of development remains incomplete and perhaps even incorrect, which could hinder the design of effective interventions. Many of our developmental theories might need to be adjusted to accurately capture individual‐level development. The theory of complex dynamic systems and person‐centered simulations offer promising avenues to do this. In addition, many promising person‐centered analysis techniques, that typically use long time series of data, are available to enhance our understanding of individual‐level development. Together, these person‐centered theoretical and empirical tools have the potential to help shift developmental science towards an understanding of development that genuinely reflects individual processes.Highlights
The problem of nonergodicity in psychological science is widespread, this highlights a need for a person‐centered approach to development.
Creating individual‐level theoretical models is a difficult challenge, but complex dynamic systems theory and simulations can help.
Person‐centered analytical techniques presented in this paper can answer questions on individual development, by investigating the shape of individual trajectories, within‐individual dynamics and nonlinear developments.
A case report on clinical features, diagnosis, and treatment of rhino‐orbito‐cerebral mucormycosis
Authors: Ding Jie‐Qiong , Xie Ying 
Published: November 2023

AbstractBackgroundRhino‐orbito‐cerebral mucormycosis (ROCM) is an opportunistic pathogenic fungal disease caused by the fungus mucor, and it is a life‐threatening fungal infection. The ulceration on the skin of the head and neck, accompanied by rhinitis, headache, orbital inflammation, and eyelid edema, should raise a high suspicion of Mucor infection in diabetic patients with inadequately controlled blood glucose.Case DescriptionThe clinical data of a patient with ROCM were analyzed retrospectively, and the clinical features were analyzed. The patient was admitted to the hospital with “diabetic hyperosmotic coma” after presenting with fatigue, poor appetite, and disturbances in consciousness as initial symptoms. After improving relevant examinations, controlling underlying diseases, and administering antifungal treatment, the final clinical outcome was death.ConclusionROCM is more prevalent in patients with uncontrolled diabetes and varied clinical manifestations. The characteristic feature is an eschar‐like necrosis of the local skin or mucosa. The gold criteria for diagnosis are pathology and fungal culture; imaging examination does not reveal any specific manifestations. Early diagnosis and effective treatment are the keys.
Clinical effects of dupilumab: A novel treatment for Kimura disease
Authors: Shang Bing‐Shiau , Hsiao Chang‐Hung , Tsao Teng‐Fu , Liao Yuan‐Ya , Lin Wea‐Lung , Lee Wen‐I , Lue Ko‐Huang 
Published: November 2023

AbstractBackgroundKimura disease (KD) is a rare chronic inflammatory disorder involving the Th2 pathway. Although medical treatment with steroids or other immunosuppressants is available, they may cause developmental issues in the pediatric population. Surgical intervention has also been suggested; however, it is associated with high recurrence rates.Case PresentationA 14‐year‐old boy presented with left retroauricular lymph node enlargement at the age of 5 years. At the age of 7 years, he was diagnosed with nephrotic syndrome which subsided after steroid treatment for approximately 6 years. The retroauricular lymph node was surgically excised, and KD was confirmed. However, recurrent enlargement of the left retroauricular and neck lymph nodes occurred after 2 years. Persistently high IgE levels and fluctuating eosinophil counts were observed following steroid treatment. Dupilumab was prescribed because of the difficulty in tapering the steroid dosage. A loading dose of 600 mg was administered, followed by a maintenance dose of 300 mg every 2 weeks. The IgE level decreased after 3 months, and a low eosinophil count was maintained after steroid discontinuation. Follow‐up computed tomography revealed a decrease in the size of the lymph nodes with no side effects such as conjunctivitis.ConclusionTraditional treatments have raised developmental concerns in the pediatric population and are associated with high recurrence rates. Dupilumab targets the Th2 pathway and provides effective results, with few adverse effects. Dupilumab may be a therapeutic option for KD and other diseases involving the Th2 pathway.
Chitosan‐sodium percarbonate‐based hydrogels with sustained oxygen release potential stimulated angiogenesis and accelerated wound healing
Authors: Waris Tayyba Sher , Shah Syed Tahir Abbas , Mehmood Azra , Mushtaq Afaq , Zehra Mubashra , Zulfiqar Saima , Andleeb Anisa , Jabbar Faiza , Anjum Muhammad Awais , Anwar Chaudhry Aqif , Rehman Ihtesham ur , Yar Muhammad 
Published: November 2023

AbstractThe prolonged hypoxic conditions hinder chronic wounds from healing and lead to severe conditions such as delayed re‐epithelialization and enhanced risk of infection. Multifunctional wound dressings are highly required to address the challenges of chronic wounds. Herein, we report polyurethane‐coated sodium per carbonate‐loaded chitosan hydrogel (CSPUO2) as a multifunctional dressing. The hydrogels (Control, CSPU, and CSPUO2) were prepared by freeze gelation method and the developed hydrogels showed high porosity, good absorption capacity, and adequate biodegradability. The release of oxygen from the CSPUO2 hydrogel was confirmed by the increase in pH and a sustained oxygen release was observed over the period of 21 days, due to polyurethane (CSPU) coating. The CSPUO2 hydrogel exhibited around 2‐fold increased angiogenic potential in CAM assay when compared with Control and CSPU dressing. CSPUO2 also showed good level of antibacterial efficacy against E. coli and S. aureus. In a full‐thickness rat wound model, CSPUO2 hydrogel considerably accelerated wound healing with exceptional re‐epithelialization granulation tissue formation less inflammatory cells and improved skin architecture highlighting the tremendous therapeutic potential of this hydrogel when compared with control and CSPU to treat chronic diabetic and burn wounds.
Obesity Considerations in Pediatric Drug Development, 2016–2021
Authors: Samuels Sherbet , Bhatt‐Mehta Varsha , Park Kyunghun , Burckart Gilbert J. 
Published: November 2023

AbstractPediatric obesity is a global public health concern. Obesity‐related physiological changes may affect the pharmacokinetics of drugs and lead to therapeutic failure or toxicities. An earlier review of pediatric drug development programs from 2007 to 2016 found that, of 89 programs listing obesity‐related terms, only 4 (4%) products described pharmacokinetic changes associated with obesity. This review examined obesity considerations for 185 drug products for which pediatric drug development programs were submitted to the US Food and Drug Administration (FDA) between 2016 and 2021. The FDA‐authored review documents and drug product labeling were queried for obesity‐related terms and the review found 97/185 (52%) drug products had obesity‐related terms in these sources. Of the 97 drug products, 55/97 (57%) had obesity‐related terms in the FDA‐authored reviews only, 13/97 (13%) had obesity‐related terms in the drug product labeling only, and 29/97 (30%) had obesity‐related terms in both FDA‐authored reviews and drug product labeling. Most of the obesity‐related information in the drug product labeling originated from data collected from adults. Only 13/185 (7%) drug product labeling contained obesity‐related terms in reference to drug pharmacokinetics. Specific dosage recommendations for the use of the drug products in pediatric patients who are obese remain lacking. The dearth of available information to guide drug dosages in the obese pediatric population suggests that further research, innovative approaches, and evidence‐based guidelines are needed to inform the optimal therapeutic use of drugs in this population.