bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan Sistem Imunitas Pada Lansia Melalui Kegiatan Fisik Di Masa Pandemi Covid-19
Authors: Nurarifah Nurarifah , Damayanti Risna 
Published: January 2024

Covid-19 dinyatakan sebagai pandemi dunia oleh WHO. Kasus Covid-19 mengalami peningkatan dan meluas ke seluruh wilayah di Indonesia sehingga diterbitkan Peraturan Pemerintah nomor 21 tahun 2020 tentang Pembatasan Nasional Berskala Besar (PSBB). Kasus covid-19 paling banyak terjadi pada kelompok rentan seperti masyarakat yang memiliki penyakit penyerta (komorbid), lansia, gangguan imunitas, dan obesitas. Lansia sebagai kelompok rentan yang memiliki resiko tinggi mengalami gejala berat sampai kematian. Tindakan pencegahan penularan Covid-19 sangat penting untuk dilakukan dengan menerapkan pola hidup bersih dan sehat. Adanya PSBB menyebabkan terbatasnya aktifitas yang dapat dilakukan selama stay at home yang dapat menyebabkan inaktifitas dan berpengaruh terhadap penurunan sistem imun pada lansia. Berdasarkan data diatas perlu adanya kegiatan penyuluhan yang bertujuan untuk meningkatkan pengetahuan lansia tentang pentingnya meningkatkan imunitas tubuh dengan aktifitas fisik olaraga sehingga diharapkan akan meningkatkan derajat kesehatan dan mutu kehidupan masyarakat dalam menghadapi pandemi Covid-19. Kegiatan ini dilaksanakan di Desa Moncongloe Lappara, Kecamatan Moncongloe, Kabupaten Maros, Sulawesi Selatan pada bulan Juni 2020. Khalayak sasaran yaitu warga lansia desa Moncongloe Lappara. Metode yang dilakukan berupa promosi kesehatan dan penyuluhan kesehatan. Kesehatan secara luring dengan menerapkan protokol kesehatan. Hasil dari kegiatan pengabdian masyarakat ini diperoleh bahwa lansia dapat memahami pentingnya kegiatan olaraga untuk meningkatkan imunitas apabila dilakukan teratur yang dapat mencegah penularan Covid-19. Kegiatan penyuluhan ini dapat pada posyandu lansia khususnya dalam melakukan aktifitas fisik seperti olaraga atau senam lansia.
Effectiveness of pharmacotherapies for diabetes on nicotine, food, and water intake in insulin-resistant rats
Authors: Ortegon Sebastian , Giner Priscilla , Cruz Bryan , Carcoba Luis M. , Clapp Benjamin , Clegg Deborah J. , O’Dell Laura E. 
Published: January 2024

The intersectionality between diabetes medications and nicotine consumption was assessed in female and male rats. Briefly, the rats were fed a high-fat diet (HFD) or regular diet (RD) for 4 weeks. Then separate groups received vehicle or a low dose of streptozotocin (STZ; 25 mg/kg). Three days later, insulin resistance was assessed by measuring plasma glucose levels for 180 min following an injection of insulin (0.75 U/kg). The rats were then prepared with jugular catheters, and they were given 23 h access to nicotine intravenous self-administration (IVSA) in 4 days cycles with 3 days of forced abstinence in their home cages where they consumed their respective diet. During the IVSA sessions, operant responses for food and water and changes in body weight were recorded. Prior to administration of the pharmacotherapies, the rats were given access to two doses of nicotine (0.015 then 0.03 mg/kg for the remainder of the study). Then, daily injections of the pharmacotherapies were given at the onset of dark cycle (6 p.m.) in the following order: 1) dapagliflozin (3.0 then 10.0 mg/kg), 2) insulin (0.75 U/kg twice), and 3) bromocriptine (3.0 then 10.0 mg/kg). The results suggest that our HFD+STZ regiment induced insulin resistance in female and male rats. Also, the HFD-fed rats displayed higher nicotine intake than RD controls, regardless of sex. Administration of insulin, but not dapagliflozin or bromocriptine, normalized nicotine intake in HFD-fed rats to control levels. These results have clinical implications regarding the potential efficacy of insulin to control excessive nicotine intake in persons with diabetes.
Investigation of laser-induced contamination on dielectric thin films in MHz sub-ps regime
Authors: Stehlik Marek , Zideluns Janis , Petite Camille , Allard Valentin , Minissale Marco , Moreau Antonin , Lereu Aude , Lemarchand Fabien , Wagner Frank , Lumeau Julien , Gallais Laurent 
Published: January 2024

High-repetition rate diode-pumped sub-ps lasers are widely used in the industrial sector for high-quality material processing applications. However, for their reliable operation, it is crucial to study the power handling capabilities of the optical components used in these systems. The optical components, such as mirrors, gratings, dichroic filters, and gain media, are designed based on dielectric thin films. When subjected to high-intensity laser radiation, the phenomenon of laser-induced contamination (LIC) can lead to the growth of a nanometric, highly absorbent layer on an irradiated optical surface, which can result in transmission or reflection loss and eventual permanent damage. In this study, we investigate LIC growth on dielectric oxide thin films in an air environment irradiated by MHz sub-ps laser at 515 nm. We examine the effect of thin film deposition method, material, and thickness on LIC growth dynamics. The irradiated spots on the surface are inspected using multiple observation methods, including white light interference microscopy and fluorescence imaging. Our results show that the LIC growth dynamics depend on the laser intensity and irradiation time and can be affected by the thin film deposition method, material, and thickness. These findings could be used to inform the development of more resistant optical components, ensuring long-term reliable laser operation required for industrial applications. The study highlights the need for validating optical components using tests that closely mimic real-world applications and provides insight into the complex processes that lead to LIC.
Case report: Lingual dystonia symptoms treated with botulinum toxin in patients with THAP1 mutation
Authors: Wagle Shukla Aparna , Herndon Nicole , Malaty Irene 
Published: January 2024

Background: THAP1 mutation dystonia is a known genetic cause of generalized dystonia. THAP1 mutation frequently presents with clinical features of bulbar dysfunction, including oromandibular and lingual dystonia. Patients complain of significant speech, chewing, and swallowing difficulties leading to major occupational and social disabilities. While bilateral globus pallidus internus deep brain stimulation (DBS) is powerful therapy for generalized dystonia and improves dystonia symptoms in the cervical and limb region, it may not improve speech despite multiple adjustments to the stimulation parameters. Treating lingual dystonia symptoms with oral medications is commonly unsatisfactory. Botulinum toxin injection, a potent therapy for focal forms of dystonia is currently underutilized in clinical practice for treating lingual dystonia.Cases: We present two patients with THAP1 mutation reporting lingual dystonia symptoms. The first patient did not meet the eligibility criteria for DBS therapy due to significant psychiatric symptoms. The second patient received DBS with improvements in cervical, limb, and trunk symptoms but complained of severe speech difficulties that did not improve despite multiple programming sessions. These patients were treated with botulinum toxin injections every 12 weeks for more than 3 years, with speech improvements lasting most of the cycle. For the most part they tolerated botulinum toxin without bothersome side effects. Along with the clinical histories, we present objective perceptual analysis of speech samples collected before and after botulinum toxin injections in one of the treatment cycles.Conclusion: Botulinum toxin injections that are clinically beneficial for mitigating lingual dystonia symptoms should be utilized to address symptoms of THAP1 mutation dystonia that may not be amenable to other therapies, such as the DBS.
Concurrent activation potentiation improves lower-limb maximal strength but not dynamic balance control in rugby players
Authors: Rizzato Alex , Dalla Costa Vittorio G. , Bozzato Matteo , Paoli Antonio , Marcolin Giuseppe 
Published: January 2024

Concurrent activation potentiation (CAP) increases athletic performance by activating muscles not involved in the performed activity. Among the CAP strategies, jaw clenching is the most practical to implement in sports contexts. Muscle strength and balance control are essential among rugby players to cope tackles. Besides combat sports, mouthguard has become mandatory also in rugby. Therefore, this study aimed to understand whether mouthguard jaw-clenching could improve rugby players’ dynamic balance and quadriceps isometric strength. Thirteen rugby players were tested under maximal-bite (MB) and no-bite (NB) conditions. During standing balance tests, an electro-actuated platform with a force plate screwed on it allowed for the perturbation of the support base of the rugby players. A verbal signal warned the subject that the perturbation was coming, mentally recalling an in-field expected collision. In the first 2.5 s window after the perturbation, the center of pressure (CoP) displacement and mean velocity were measured. The first peak, the maximal oscillations, and the standard deviation of the anterior-posterior CoP trajectory were calculated within the same time window. In the isometric leg-extension test, a custom-built chair instrumented with a uni-axial load cell allowed to collect the maximal strength and rate of force development (RFD). Mouthguard jaw-clenching did not affect CoP-related parameters but increased maximal strength (p&lt; 0.05) and RFD (0–50 ms:p&lt; 0.01; 50–100 ms:p&lt; 0.001; 100–150 ms:p&lt; 0.05) in the isometric leg-extension test. Mouthguard jaw-clenching alone could be useful to increase lower-limb maximal isometric strength and RFD but did not improve dynamic balance performance in a sport-oriented postural balance test.
Racial disparities in receipt of survivorship care plans among female cancer survivors in Maryland
Authors: Jin Mu , Jones Miranda R. , Connor Avonne E. 
Published: January 2024

BackgroundWith the increasing number of cancer survivors in the US, survivorship care plans (SCP) have been promoted to improve survivorship outcomes for cancer patients. Few studies have assessed if the receipt of SCPs differs by race/ethnicity. This study evaluated if racial/ethnic disparities exist in SCP receipt among female cancer survivors living in Maryland.MethodsSurvey data were analyzed for 1,353 non-Hispanic white (NHW) and 280 non-Hispanic Black (NHB) women with a self-reported history of cancer living in Maryland who completed the Maryland Behavioral Risk Factor Surveillance Survey (BRFSS) between 2011 and 2020. Multivariable logistic regression models were used to estimate prevalence odds ratios (PORs) and 95% confidence intervals (CI) for SCP receipt by race/ethnicity. Models were further stratified by demographic, cancer-related, and lifestyle factors to examine effect modification.ResultsOn average, survivors were 66.8 years of age at time of BRFSS survey and 53.5 years of age at time of cancer diagnosis. Compared with NHW survivors, NHB survivors reported higher odds of receiving a summary of cancer treatments (POR = 3.81, 95% CI: 2.27, 6.39), instructions from a doctor for follow-up check-ups (POR = 2.10, 95% CI: 1.00, 4.39), and written or printed instructions (POR = 4.74, 95% CI: 2.12, 10.61). Age at survey (&lt;65 years vs. ≥65 years) (p-interaction term = 0.01) and income level (≤50k vs. &gt;50k) (p-interaction term = 0.04) significantly modified the relationship between race/ethnicity and receiving SCPs.ConclusionOur findings indicate that NHB female cancer survivors in Maryland are more likely to receive SCP information compared to NHW survivors and this association is significantly modified by age at survey and income level. More research is needed at the patient-provider level to gain a better understanding of the impact of SCP delivery to minority cancer populations.
Association of sex with post-arrest care and outcomes after out-of-hospital cardiac arrest of initial shockable rhythm: a nationwide cohort study
Authors: Hosomi Sanae , Irisawa Taro , Nakao Shunichiro , Zha Ling , Kiyohara Kousuke , Kitamura Tetsuhisa , Ogura Hiroshi , Oda Jun 
Published: January 2024

BackgroundResearch has described differences in the provision of prehospital treatment for women who experience out-of-hospital cardiac arrest. However, studies have reported conflicting results regarding survival outcomes or in-hospital interventions between sexes. Thus, this study aimed to investigate the association of sex with survival outcomes and in-hospital treatments in Japan.MethodsWe retrospectively analyzed data from the Japanese Association for Acute Medicine–Out-of-Hospital Cardiac Arrest Registry. Patients aged ≥18 years who presented with a shockable rhythm at the scene between June 2014 and December 2020 were included in our analysis. Outcome measures were 30-day survival and in-hospital interventions. We compared the outcomes between the sexes using multivariable logistic regression.ResultsIn total, 5,926 patients (4,270 men; 1,026 women) with out-of-hospital cardiac arrest were eligible for our analysis. The proportions of patients with 30-day survival outcomes were 39.5% (1685/4,270) and 37.4% (384/1,026) in the male and female groups, respectively (crude odds ratio, 0.92; 95% confidence interval, 0.80–1.06). Although there were no significant differences, survival outcomes tended to be better in women than in men in the multiple regression analysis (adjusted odds ratio: 1.38; 95% confidence interval: 0.82–2.33). Furthermore, there was no significant difference between the sexes in terms of patients who received extracorporeal cardiopulmonary resuscitation (adjusted odds ratio: 0.81; 95% confidence interval: 0.49–1.33) or targeted temperature management (adjusted odds ratio: 0.99; 95% confidence interval: 0.68–1.46).ConclusionsAfter adjusting for prognostic factors, there were no differences in survival rates and in-hospital interventions between men and women.
Local impedance and contact force guidance to predict successful cavotricuspid isthmus ablation with a zero-fluoroscopy approach
Authors: Melero-Polo Jorge , Cabrera-Ramos Mercedes , Alfonso-Almazán Jose Manuel , Marín-García Isabel , Montilla-Padilla Isabel , Ruiz-Arroyo José Ramón , López-Rodríguez Guillermo , Ramos-Maqueda Javier 
Published: January 2024

IntroductionA new technology capable of monitoring local impedance (LI) and contact force (CF) has recently been developed. At the same time, there is growing concern regarding catheter ablation performed under fluoroscopy guidance, due to its harmful effects for both patients and practitioners. The aim of this study was to assess the safety and effectiveness of zero-fluoroscopy cavotricuspid isthmus (CTI) ablation monitoring LI drop and CF as well as to elucidate if these parameters can predict successful radiofrequency (RF) applications in CTI ablation.MethodsWe conducted a prospective observational study recruiting 50 consecutive patients who underwent CTI ablation. A zero-fluoroscopy approach guided by the combination of LI drop and CF was performed. In each RF application, CF and LI drop were monitored. A 6-month follow-up visit was scheduled to assess recurrences.ResultsA total of 767 first-pass RF applications were evaluated in 50 patients. First-pass effective RF applications were associated with greater LI drops: absolute LI drops (30.05 ± 6.23 Ω vs. 25.01 ± 5.95 Ω), p = 0.004) and relative LI drops (−23.3 ± 4.9% vs. −18.3 ± 5.6%, p = 0.0005). RF applications with a CF between 5 and 15 grams achieved a higher LI drop compared to those with a CF below 5 grams (29.4 ± 8.76 Ω vs. 24.8 ± 8.18 Ω, p &lt; 0.0003). However, there were no significant differences in LI drop between RF applications with a CF between 5 and 15 grams and those with a CF beyond 15 grams (29.4 ± 8.76 Ω vs. 31.2 ± 9.81 Ω, p = 0.19). CF by itself, without considering LI drop, did not predict effective RF applications (12.3 ± 7.54 g vs. 11.18 ± 5.18 g, p = 0.545). Successful CTI ablation guided by a zero-fluoroscopy approach was achieved in all patients. Only one patient experienced a recurrence during the 6-month follow-up.ConclusionsLI drop (absolute and relative values) appears to be a good predictor of successful RF applications to achieve CTI conduction block. The optimal CF to achieve a good LI drop is between 5 and 15 g. A zero-fluoroscopy approach guided by LI and CF was feasible, effective, and safe.
Age at first birth, age at menopause, and risk of ovarian cyst: a two-sample Mendelian randomization study
Authors: Su Qian , Yang Zhiyong 
Published: January 2024

BackgroundIncreasing observational studies have indicated that hormonal reproductive factors were associated with ovarian cyst, a common gynecological disease. A two-sample Mendelian randomization (MR) was carried out by investigating the causality of reproductive factors including age at first birth (AFB), age at natural menopause (ANM), and age at menarche (AAM), and the risk of ovarian cyst (OC).MethodSummary statistics were collected from a large genome-wide association study (GWAS), and we used a two-sample MR study to clarify the causal association between the exposure of AFB (N = 542,901), ANM (N = 69,360), and AAM (N = 29,346) and the outcome of the OC (Ncase = 20,750, Ncontrol = 107,564). We separately selected 51, 35, and 6 single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for assaying the influence of AFB, ANM, and AAM on OC, respectively. Then, the causal relationship was tested through multiple approaches including an inverse-variance weighted method, an MR-Egger regression, and a weighted median method. In addition, the MR-PRESSO method was also used to verify the horizontal pleiotropy. Subsequently, we adjust the confounders for MR design.ResultsThe MR analysis results showed that AFB was negatively associated with the OC (IVW Beta: −0.09, OR: 0.91, 95% CI: 0.86–0.96, p = 0.00185), and the greater AAM decreased the risk of OC (IVW Beta: −0.10, OR: 0.91, 95% CI: 0.82–0.99, p = 0.0376). However, ANM has a positive correlation with the OC (IVW Beta: 0.05, OR: 1.05, 95% CI: 1.03–1.08, p = 8.38 × 10−6). After adjusting BMI, alcohol intake frequency, and ever smoked, we also obtained a negative relationship between AFB and OC (p &lt; 0.005). Meanwhile, we adjusted weight, alcohol intake frequency, and height, and then found a causal relationship between older AMN and an increased risk of OC (p &lt; 0.005).ConclusionA causal effect of reproductive factors on the development of OC, affected by AFB, ANM, and AAM, was found convincingly. After adjusting the confounders, we also successfully found the substantial causal effect of younger AFB, younger AAM, and older ANM on an increased risk of OC.
Correlation between the non-use of cooking oil fume extractors and bone mineral density in population aged 45 years and older in China: a cross-sectional study
Authors: Zhang Haitao , Shi Binhao , Yuan Chunchun , Huang Chen , Huang Tingrui , Liao Zhangyu , Zhu Wenhao , Zhong Wei , Xu Hongbin , Ji Jiangxun , Cai Feihong , Chen Yue , Sun Pan , Zeng Xianhui , Yang Zhiwu , Wang Jing , Shu Bing , Liang Qianqian , Shi Qi , Xu Chuanglong , Tang Dezhi , Wang Yongjun 
Published: January 2024

IntroductionThe correlation between the non-use of cooking oil fumes (COFs) extractors and bone mineral density (BMD) have not been clarified. Consequently, this study attempted to explore the impact of non-use COFs extractors on BMD in population aged 45 years and older based on a cross-sectional study.MethodsThis study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study in China. The multivariate linear regression models were used to evaluate the correlation between the non-use of fume extractors in family cooking and total lumbar spine (LS), femoral neck (FN), total hip BMD and levels of bone metabolism markers.ResultsA total of 3433 participants were included in the final analyses, of which 2607 (75.93%) participants used fume extractors. The results of models indicated that there were significant correlations of the non-use of fume extractors on total LS BMD (β = -0.024, 95% CI, -0.036, -0.012, p &lt; 0.001), PINP (β = 4.363, 95% CI, 2.371, 6.356, p &lt; 0.001) and ALP (β = 4.555, 95% CI, 2.593, 6.517, p &lt; 0.001) levels.ConclusionsThis study verified that the use of fume extractors is an efficacious measure to prevent LS bone loss. For the sake of public bone health, people should install a fume extractor in the kitchen and use it routinely when cooking.
Has GVC participation exacerbated inequality of the embodied carbon in fossil energy industry export trade?
Authors: Zheng Minggui , Ni Jingsheng , Wen Donghong 
Published: January 2024

Introduction: The fossil energy sector is an important part of international trade, and the flow of products between sectors will bring about the flow of embodied carbon. There are relatively few studies on embodied carbon in the fossil energy sector, which are mostly concentrated in other sectors and are not well integrated with GVC. Combining embodied carbon with GVC provides a better view of the allocation of environmental responsibility in trade. At the same time, it can also help different countries to improve the environment with the help of GVC.Methods: This research is based on the World Input–Output Database. First, by using multi-regional input–output, this paper measures fossil energy trade embodied carbon (FEE) data of 39 countries from 2000 to 2014; second, using structural decomposition analysis, we find what factors affect FEE. Finally, we analyze theimpact of global value chain (GVC) on the FEE.Results: This study obtained the following conclusions: 1) different GVCs have different effects on the embodied carbon in trade. Simple forward, complex forward, and simple backward to embedded play a positive role. The complex backward GVC has a negative impact; 2) high-income countries can get greater positive environmental effects through GVC, and middle-income countries cannot obtain or obtain less environmental effects; and 3) the backward GVC affects the FEE by affecting the proportion of fossil energy consumption.Discussion: The results show that the FEE shall be jointly responsible for the world’s countries, and different countries should make different contributions to the world’s environmental protection comprehensively considering factors such as the economic development level of various countries. This proposes relevant policy suggestions in China.