bluuebunny/crossref_metadata_2025_split huggingface dataset:
Montane Seasonal and Elevational Precipitation Gradients in the Southern Rockies of Alberta, Canada
Authors: Barnes Celeste , MacDonald Ryan J. , Hopkinson Chris 
Published: January 2025

ABSTRACTModelling precipitation inputs in mountainous terrain is challenging for water resource managers given sparse monitoring sites and complex physical hydroclimatic processes. Government of Alberta weather station uncorrected and bias‐corrected precipitation datasets were used to examine elevational precipitation gradients (EPGs) and seasonality of EPGs for six South‐Saskatchewan River headwater sites (alpine, sub‐alpine, valley). January EPG from valley to alpine sites (730 m elevation difference) using uncorrected precipitation was 19 mm/100 m. Corrected EPG was approximately three times greater (61 mm/100 m). The valley received more precipitation than the alpine (inverse EPG) in late spring and summer. A seasonal signal was present whereby all sites demonstrated 50%–70% lower summertime precipitation relative to winter months, with the greatest seasonal variance at the alpine site. Winter watershed‐level spatialized precipitation volume was compared to modelled snow water equivalent (SWE) associated with two late‐winter airborne lidar surveys. Uncorrected volumes (2020: 64.0 × 106m3, 2021: 63.2 × 106m3) were slightly higher than modelled mean SWE (2020: 51.6 × 106m3, 2021: 44.2 × 106m3) whereas bias‐corrected (2020: 120.5 × 106m3, 2021: 119.7 × 106m3) almost doubled the estimate. Corrected precipitation is assumed closer to the true value. Cumulative sublimation, evaporation and snowmelt losses result in ground‐level snowpack yield that deviates from total atmospheric precipitation in an increasingly negative manner. The 2020/2021 simulations suggest wintertime atmospheric precipitation exceeds late‐winter snowpack accumulation by up to 57% and 63%, respectively. A loss of 16 × 106m3 (7%) watershed SWE from the alpine zone was partially attributed to redistribution downslope to the treeline‐ecotone. Physical snowpack losses from sublimation and melt, or modelling uncertainty due to precipitation correction and alpine snow‐density uncertainties can also contribute to observed discrepancies between in situ SWE and cumulative precipitation. Ignoring bias‐correction in headwater precipitation estimates can greatly impact headwater precipitation volume estimates and ignoring EPG seasonality is likely to result in under‐estimated winter and over‐estimated summer yields.
From hysterectomy to diagnosis: Histopathologic confirmation of genitourinary schistosomiasis in a patient after hysterectomy—A case report
Authors: Neves da Silva Margarida , Leal Mariana , Campos Marta , dos Santos Joana , Lira Morais Mariana , Pinelo Sueli , Brito Teresa , Novais Veiga Mariana 
Published: January 2025

SynopsisA 44‐year‐old Angolan woman was diagnosed with asymptomatic genitourinary schistosomiasis through histopathology after a hysterectomy, demonstrating the complexities of diagnosing this parasitic infection.
Intergenerational impacts of racial discrimination on child executive functioning problems
Authors: Barbee Nia R. , Dunlop Anne L. , Corwin Elizabeth , Brennan Patricia A. 
Published: January 2025

AbstractThe proposed study sought to investigate whether maternal experiences of racial discrimination and gendered racial stress are associated with offspring executive functioning. Total 266 Black mother–child pairs in the United States were assessed from pregnancy through child age of 4 years. We hypothesized that children whose mothers reported higher rates of perceived gendered racial stress during pregnancy and racial discrimination throughout their lifetime would have lower scores on executive functioning assessments. Furthermore, we hypothesized that low maternal education and income would act as risk moderators whereas social support would act as a protective moderator in the associations between maternal experiences of discrimination (EOD) and child executive functioning. Main effect findings support our hypothesis of an intergenerational association between maternal EOD and gendered racial stress and lower child executive functioning scores. Income was a significant moderator. As hypothesized, the association between mothers reports of lifetime discrimination and lower child executive functioning scores was stronger at lower levels of income. In contrast, however, the association between maternal prenatal reports of gendered racial stress and lower child executive functioning scores was stronger at higher levels of maternal education and income. Social support did not have a significant moderating effect on any of the association.
Rutin Attenuates Pirarubicin‐Induced Cardiomyocyte Injury by Knocking Down lncRNA Miat
Authors: Huang Peng , Yan Kaixu , Zhang Wenqing , Ji Jiahua , Wei Dexian , Zheng Wentao , Li Lu , Ren Liqun 
Published: January 2025

ABSTRACTPirarubicin (THP) is a widely used chemotherapeutic agent for breast cancer, but its clinical use is limited by its cardiotoxicity. In our previous study, we found that rutin (RUT), the main active ingredient in the traditional Chinese medicine Sophora japonica, could attenuate THP‐induced cardiotoxicity. The aim of this study was to further investigate the potential role and mechanism of RUT in attenuating THP‐induced cardiotoxicity. We examined the expression of lncRNA Miat in mouse cardiomyocytes (HL‐1) under the intervention of THP/THP + RUT, respectively. Then we evaluated the protective effect of RUT on THP‐induced HL‐1 by CCK8, TUNEL, reactive oxygen species (ROS) assay and Western Blot. The mediating role of lncRNA Miat was verified by transfection of overexpression lncRNA Miat plasmid. The results showed that RUT increased cell viability, inhibited apoptosis, reduced ROS accumulation and decreased calcium overload in THP‐induced HL‐1. While overexpression of Miat significantly abrogated the therapeutic effect of rutin. In conclusion, RUT attenuates THP‐induced myocardial injury by downregulating lncRNA Miat.
Relative Importance of Accounting Standards and National Regulatory Frameworks on Opportunistic Asset Sales Decisions
Authors: Campa Domenico , Donnelly Ray 
Published: January 2025

ABSTRACTWe use a sample of UK‐listed firms reporting under IFRS and US listed firms reporting under US GAAP, and a second sample of UK firms cross‐listed in the US and reporting under IFRS matched with US domestic firms reporting under US GAAP, to explore differences in earnings management through asset sales between IFRS and US GAAP reporters. In the first sample, we find that both US and UK firms use asset sales to manage earnings upward at the benchmark of zero earnings, but only UK companies use asset sales to smooth income. Our second sample shows a consistent and similar use of asset sales for income smoothing purposes for companies reporting under IFRS and US GAAP that are subject to the same (US) regulatory environment. Our results suggest that the regulatory environment rather than accounting standards is pivotal in the decision to use asset sales to manage earnings.
Chronic Severe Neutropenia Associated With Intravenous Immunoglobulin for Multifocal Motor Neuropathy
Authors: Ugarte Shannon , Gebhard Talia , Cornblath David R. , Scherer Steven S. , Babushok Daria V. 
Published: January 2025

ABSTRACTIntravenous immunoglobulin (IVIG) is an immunomodulatory therapy derived from pooled donor immunoglobulins and used for treatment of various autoimmune conditions. Here we report the diagnosis and management of IVIG‐induced chronic severe neutropenia with absolute neutrophil count <0.5×103/µL in a patient with multifocal motor neuropathy. Serial blood count showed a cyclical pattern of neutropenia: worsening 24–48 h post‐IVIG, then gradually improving before the next infusion. IVIG‐induced neutropenia is rare, with previous reports of predominantly mild transient neutropenia. Our case describes chronic severe neutropenia that developed years after starting IVIG. We summarize available evidence and management strategies for IVIG‐associated neutropenia.
Synthesis of Terminal Alkenylindolines via Rhodium‐Catalyzed Direct CH Alkenylation With Alkenyl Borates
Authors: Wang Liang , He Xiaoyu , Luo Cheng , Li Pengjie , Mei Yina , Gong Cheng , Wang Yimeng , Zhang Jin 
Published: January 2025

ABSTRACTAn efficient method for the synthesis of valuable terminal C7‐alkenylated indolines through the direct C–H alkenylation of N‐pyridinyl indolines in the presence of a rhodium catalyst has been developed. Alkenyl borates were first used as a useful alkenyl reagent for C–H functionalization of indolines. Under mild reaction conditions, a series of indolines with different functional groups were compatible in this transformation, affording the C7‐alkenylated product in good to excellent yields. Moreover, the C7‐alkenylated indoline can be conveniently converted to the pyrroloquinoline derivative, which is a popular tricyclic indoline skeleton in bioactive compounds, highlighting its potential application value.
Fullerene (C60 & C70)‐Meso‐Tris‐4‐Carboxyphenyl Porphyrin Dyads Inhibit Entry of Wild‐Type and Drug‐Resistant HIV‐1 Clades B and C
Authors: Sharma Debdulal , Rai Madhu , Singh Aradhana , Gaur Ritu , Sengupta Devashish 
Published: January 2025

ABSTRACTThe biological applications of noncationic porphyrin‐fullerene (P‐F) dyads as anti‐HIV agents have been limited despite the established use of several cationic P‐F dyads as anti‐cancer photodynamic therapy (PDT) agents. This article explores the potential of amphiphilic non‐cationic porphyrin‐fullerene dyads as HIV‐1 inhibitors under both PDT (light‐treated) and non‐PDT (dark) conditions. The amphiphilic P‐F dyads, PB3C60 and PB3C70, demonstrated enhanced efficacy in inhibiting the entry and production of HIV‐1 (subtypes B and C). Under light‐harvested conditions, the dyads exhibited potent inhibitory effects (EC50 for PB3C60 and PB3C70 < 10 nM) and also maintained significant inhibition under non‐PDT conditions (EC50 for PB3C60 = 1.43 μM and PB3C70 = 1.50 μM), while displaying notably reduced toxicity compared to their water‐soluble porphyrin precursor. The P‐F dyads exhibited substantial efficacy in neutralizing the T20‐resistant strain 9491, both at the entry and postentry phases, thereby addressing the challenge of drug resistance.
The Effect of HBV Therapy on Glycemic Control in HBV‐Infected Patients With Diabetes: A 90‐day Multicenter Study
Authors: Liu Qi , Huang Jie , Hu Jingyi , Ding Yujing , Wang Yue , Zhang Pan , Zhang Zhenlan , Liu Ying , Li Boqi , Xiao Biao , Cai Ting , Yue Tingting , Li Xia , Reza Pourkarim Mahmoud , De Clercq Erik , Zhou Zhiguang , Xiao Yang , Li Guangdi 
Published: January 2025

ABSTRACTPatients with diabetes are at increased risk of HBV infection; however, the effects of HBV infection and anti‐HBV therapy on the management of type 1 diabetes (T1D), type 2 diabetes (T2D), and latent autoimmune diabetes in adults (LADA) remain unclear.From 2016 to 2023, we recruited a multicenter cohort of 355 HBV‐infected inpatients, including 136 with T1D, 140 with T2D, and 79 with LADA. The control group included 525 HBV‐uninfected inpatients, comparing 171 with T1D, 204 with T2D and 150 with LADA. We employed propensity‐score matching between cases and controls to minimize confounding effects. Hemoglobin A1c (HbA1c) was monitored at baseline and at months 1, 2, and 3.At baseline, median HbA1c was significantly higher in HBV‐infected patients compared to their HBV‐uninfected controls: T1D (10.4% vs. 7.5%, p < 0.01), T2D (9.6% vs. 8.6%, p = 0.01), and LADA (9.4% vs. 8.4%, p = 0.03). Baseline HbA1c levels were significantly lower in HBV‐treated patients compared to those HBV‐untreated patients, regardless of whether they were on antidiabetic therapy (p < 0.05). A 90‐day follow‐up consistently indicated lower HbA1c levels at baseline, as well as at months 1, 2, and 3 among HBV‐treated patients with T1D, T2D, or LADA. Both univariate and multivariate analyses identified HBV therapy (OR = 0.44, p < 0.001) and antidiabetic treatment(OR = 0.51, p = 0.031) as protective factors for glycemic control in HBV‐infected patients with diabetes.Poor glycemic control is found in HBV‐infected patients with diabetes, but the intervention of anti‐HBV therapy and antidiabetic treatment contributes to improved glycemic control in HBV‐infected patients with T1D, T2D, or LADA.
Exploring the Interplay Between Cervicovaginal Microbiome, HPV Infection, and Cervical Intraepithelial Neoplasia in Taiwanese Women
Authors: Yang Chung‐Yao , Chang Ting‐Chang , Lee Yi‐Tzu , Shih Ting‐Ying , Li Chang‐Wei , Cheng Chao‐Min 
Published: January 2025

ABSTRACTThis study examined the relationship between the vaginal microbiome, HPV infection, and cervical intraepithelial neoplasia (CIN) in 173 women. Subjects were grouped by HPV status and cervical lesion severity, ranging from HPV‐negative to CIN Grade 2 or higher. Using VALENCIA classification, the study identified different community state types (CSTs) of vaginal microbiota, with CST IV subtypes (Staphylococcus dominated) showing high diversity and increased pathogenic bacteria. Results showed a higher microbial diversity in women with CIN compared to HPV‐negative women, with specific microbial profiles like Enterococcus faecalis and Staphylococcus aureus correlating with HPV infection severity. LEfSe and STAMP analyses revealed that particular bacterial species, such as Fannyhessea vaginae and Sneathia vaginalis, could serve as biomarkers for HPV and CIN status. Furthermore, Streptococcus and Staphylococcus were associated with HPV genotypes α7 and α9, respectively. These findings highlight how the composition of vaginal microbiota may influence HPV persistence and CIN progression, emphasizing the need for further research into microbial dysbiosis as a potential target for cervical cancer prevention and management.
Metacaspases‐Like Proteases of Trichomonas vaginalis: In Silico Identification and Characterization
Authors: Torres‐Romero Julio César , Alvarez‐Sánchez María Elizbeth , Morales‐Reyna Marcos , Bellavista‐Caballero Andrea , Arreola Rodrigo , Alvarez‐Sánchez Leidi C. , Lara‐Riegos Julio 
Published: January 2025

ABSTRACTMetacaspases (MCA), are cysteine‐dependent proteases closely related to caspases. In protozoa, MCA plays an important role in programmed cell death (PCD). In Trichomonas vaginalis, a kind of PCD that resembles apoptosis has been described, but the activators of this mechanism have not been demonstrated. We performed a genome‐wide in silico analysis in the T. vaginalis database using consensus MCA domains. A total of 15 protein annotations for MCA‐like sequences were retrieved. Only 7/15 (TvMCA1‐6 and TvMCA9) of the sequences were annotated as putative MCA and exhibited a similar range of amino acid length in comparison to the consensus sequences used for the query. By in silico analysis, we found that they are thermostable, hydrophilic proteins with molecular weights ranging from 27 to 33 KDa and their theoretical isoelectric points are in a 5.08–8.57 range. The phylogenetic analysis showed the similarity of conserved motifs for the predicted TvMCA proteins. 3D structure prediction by homology modeling demonstrated that TvMCA proteins show a similar conformation to crystallized MCA proteins. Taken together, our results indicate that these trichomonad proteins have conserved sequences like MCA proteins and suggest that they may be responsible for proteolytic activity during a PCD‐like mechanism in this parasite.
Effect of initial bone morphology on alveolar bone remodeling following molar extraction: A retrospective study
Authors: Lin Ren‐Jie , Dai Anna , Huang Jia‐Ping , Wang Meng , He Wen‐Tao , Ding Pei‐Hui 
Published: January 2025

AbstractBackgroundThe clinical evidence about alveolar ridge changes following molar extraction and how the alveolar bone morphology influences the ridge dimensional changes remains limited.MethodsA total of 192 patients with 199 molar extractions were included in this retrospective study. Cone‐beam computed tomography (CBCT) images of patients were obtained 0–3 months pre extraction and 6–12 months post extraction. Outcome variables included the change rate in ridge height and width. The effect of morphology on the outcomes was explored by single‐factor analysis, correlation analysis, and a multiple linear regression model.ResultsSignificant resorption of alveolar bone occurred vertically and horizontally after molar extraction. Jaw, furcation involvement, number of roots, number of bone wall defects, extraction reasons, overall relative bone loss (RBL), bone height of the furcation region, thickness of the lingual/palatal wall, and height difference between buccal and lingual/palatal walls (|HB‐HL|) were significantly correlated with the change in the height of the central alveolar bone (HC). The number of bone wall defects, overall RBL, and |HB‐HL| were significantly correlated with horizontal width change. HC resorption was higher in sockets with |HB‐HL| > 2.5 mm and overall RBL > 50%.ConclusionsThe alveolar bone presented significant resorption after extraction. Anatomical characteristics affected the dimensions of the alveolar bone after molar extraction. When the initial overall RBL was severe or |HB‐HL| was larger, the loss of alveolar bone dimensions was even more.Plain Language SummaryIn recent years, it has been demonstrated that the local anatomical morphology of extraction sites may influence the process of alveolar bone remodeling. However, most studies have focused on the anterior teeth, with fewer investigations addressing molar extraction sites. Therefore, we aimed to describe ridge changes following molar extraction and investigate how alveolar bone morphology influences ridge dimensional changes. In this retrospective study, we included a total of 199 alveolar sockets from 192 patients with molar extractions and obtained the corresponding cone‐beam computed tomography (CBCT) images 0–3 months pre extraction and 6–12 months post extraction. The results showed significant resorption of the alveolar bone following molar extraction. We found that anatomical characteristics significantly affect the dimensions of the alveolar bone after molar extraction. Specifically, the loss of alveolar bone dimensions was greater when the initial overall relative bone loss (RBL) was severe or when the difference between buccal and lingual/palatal walls was greater.
Rapid Identification of Plastic Beverage Bottles by Using Raman Spectroscopy Combined With Machine Learning Algorithm
Authors: Liu Xinlei , Wang Lei , Li Wei , Wan Jingwei 
Published: January 2025

ABSTRACTRapid and accurate identification of plastic beverage bottles is of great importance because plastic beverage bottles can be encountered as physical evidence in cases involving assaults, thefts, and homicides. In this experiment, 40 commercially available plastic beverage bottles were collected as experimental samples, and their Raman spectral data were collected. Initially, the samples were classified into two categories of polyethylene terephthalate (PET) and polyethylene (PE), and the 35 PET samples were further clustered into three categories by K‐means clustering. Savitzky–Golay algorithm smoothing, standard normal variate, multiple scattering correction, and first‐order derivatives were utilized to improve the quality of the Raman spectra. A convolutional neural network (CNN) model was constructed for the classification and identification, and four evaluation indexes, such as accuracy, precision, recall, and F1‐score, were utilized to compare the model's performance under the four types of preprocessing. The results show that the spectral data preprocessing combining SG and MSC has higher accuracy than other preprocessing methods, and the CNN classification model has the best performance, with 100% correct classification rate in both the training set and the test set, respectively. In conclusion, the results show that convolutional neural networks, when used in combination with Raman spectroscopy, can quickly detect the type of plastic beverage bottle, which is crucial for solving crimes.
Modeling effects of climate change on crop phenology and yield of wheat–maize cropping system and exploring sustainable solutions
Authors: Chauhdary Junaid Nawaz , Li Hong , Pan Xuwei , Zaman Muhammad , Anjum Shakeel Ahmad , Yang Fan , Akbar Nadeem , Azamat Urunbayev 
Published: January 2025

AbstractBACKGROUNDWheat–maize cropping systems in semi‐arid regions are expected to be affected by climate change in the future, which is alarming for global food security, environmental sustainability and socioeconomic development. Therefore, management practices like optimized plant geometry and fertilization need to be explored to counter these expected threats. To do this, the APSIM model was calibrated using 5‐year data (from 2017/2018 to 2022) regarding yield, biomass, plant height, emergence, anthesis and crop maturity of wheat and maize from farmer fields.RESULTSThe performance of a model run was assessed using root mean square error, normalized root mean square error, coefficient of residual mass, coefficient of determination (R2) and Nash–Sutcliffe efficiency, whose average was 1.59, 0.13, 0.001, 0.84 and 0.78, respectively, for calibration while 2.75, 0.20, −0.009, 0.80 and 0.75, respectively, for validation. Regarding crop phenology, it was modelled that the emergence, anthesis and maturity were earlier by 7–9 days, 8–10 days and 2–6 days, respectively, for wheat; 6–10 days, 13–20 days and 16–24 days, respectively, for spring maize; 3–5 days, 5–11 days and 8–19 days, respectively, for autumn maize under different climate change scenarios in near to far future. Simulations revealed the average reduction in the yield of wheat, spring maize and autumn maize by 11.5%, 11.8% and 11.0%, respectively, in near future (2025–2065) while 17.5%, 20.5% and 17.0%, respectively, in far future (2066–2100). Further, simulations discovered the potential of higher levels of fertilization (nitrogen = 60–100 kg ha−1 and phosphorus = 40–75 kg ha−1 for wheat while nitrogen = 75–120 kg ha−1 and phosphorus = 40–80 kg ha−1 for maize) and plant density (100 to 150 plants m−2 for wheat and 8 to 13 plants m−2 for maize) to enhance the yield of wheat, spring maize and autumn maize by 31–36%, 22–38% and 26–43%, respectively, in near future while 33–38%, 21–55% and 19–31%, respectively, in far future.CONCLUSIONSThe findings underscore the effects of climate change on wheat–maize cropping systems and the importance of implementing optimized fertilization and adjusting plant density to mitigate the adverse effects of climate change, thereby safeguarding food security and sustaining agricultural productivity. © 2025 Society of Chemical Industry.