bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical Ultrathin Metal‐Atomic Layer Deposition for Silica Microenvironment‐Assisted Cu‐Based Catalysis
Authors: Jeevanandham Sampathkumar , Maji Ankur , Acharya Anubhab , Kumari Nitee , Gu Byeong Su , Yoon Youngkwan , Choi Hee Cheul , Kumar Amit , Lee In Su 
Published: December 2023

AbstractReplacing commonly used precious and rare noble metals by the abundant copper (Cu)‐based catalysts is highly desired for sustainable fine‐chemical synthesis. However, in the lack of model platforms, complex surface chemistry of randomly nanostructured bulk Cu is notoriously challenging to understand and control. By synthesizing ultrathin 2D‐Cu layer sandwiched inside the bilayer silica template, an unusual but critical cooperative role of Lewis basic amino‐silica microenvironment for [Cu]‐catalyzed selective hydrogenation of unsaturated C─C bonds in diverse alkynes, ene‐ynes, and α,β‐unsaturated (alkene) Michael acceptors is discovered. Newly developed nanospace‐confined electrochemical (eChem) atomic layer deposition (NC‐EAD) technique afforded < 2 nm ultrathin Cu(0)‐layer intimately covered inside silica envelope. This model platform aided the detailed mechanistic study deciphering the unexpected finding – originally non‐reactive Cu‐film, just by a simple silica coating step, turning into an efficient catalyst for scalable fine‐chemical synthesis. The concept of reactive metal surface‐microenvironment manipulation, presents a new paradigm for controlling complex molecular interactions in heterogeneous catalysts.
Leveraging Surface Chemistry and Pore Shape Engineering in a Metal‐Organic Framework for One‐Step Olefin Purification
Authors: Lian Xin , Liu Pu‐Xu , Yuan Yue‐Chao , Pang Jing‐Jing , Li Lin , Liu Shan‐Shan , Yue Bin , Zhang Ying‐Hui , Li Libo , Xu Jian , Bu Xian‐He 
Published: December 2023

AbstractPurifying olefin from ternary paraffin/olefin/alkyne mixtures through a one‐step adsorption process is extremely desirable. Herein, a stable zirconium(IV) metal‐organic framework with a customized pore surface composed of nonpolar phenyl and slightly polar thiophene rings is reported to access the adsorption preference of paraffin and alkyne over olefin. Noteworthily, this material displays a superior ability to discriminate C3 hydrocarbon molecules, which is principally more challenging compared with C2 ones and rarely documented. Computational studies disclose that its featured pore shape fits well with C3 gas molecules, enabling them to get close contact with the immobilized affinity sites. Leveraging surface chemistry and pore shape engineering synergistically gives rise to excellent C3 adsorption capacities (>5 mmol g−1) and concurrently high C3H8/C3H6 (1.4) and C3H4/C3H6 (1.9) selectivities (at 298 K and 1 atm). Dynamic column breakthrough experiments demonstrate that one‐step purification of C2H4 and C3H6 can be simultaneously realized on this material.
Near‐Infrared Nanophosphors Based on CuInSe2 Quantum Dots with Near‐Unity Photoluminescence Quantum Yield for Micro‐LEDs Applications
Authors: Lian Wei , Tu Datao , Weng Xukeng , Yang Kaiyu , Li Fushan , Huang Decai , Zhu Haomiao , Xie Zhi , Chen Xueyuan 
Published: December 2023

AbstractHighly efficient near‐infrared (NIR) luminescent nanomaterials are urgently required for portable mini or micro phosphors‐converted light‐emitting diodes (pc‐LEDs). However, most existing NIR‐emitting phosphors are generally restricted by their low photoluminescence (PL) quantum yield (QY) or large particle size. Herein, a kind of highly efficient NIR nanophosphors is developed based on copper indium selenide quantum dots (CISe QDs). The PL peak of these QDs can be exquisitely manipulated from 750 to 1150 nm by altering the stoichiometry of Cu/In and doping with Zn2+. Their absolute PLQY can be significantly improved from 28.6% to 92.8% via coating a ZnSe shell. By combining the phosphors with a commercial blue chip, an NIR pc‐LED is fabricated with remarkable photostability and a record‐high radiant flux of 88.7 mW@350 mA among the Pb/Cd‐free QDs‐based NIR pc‐LEDs. Particularly, such QDs‐based nanophosphors acted as excellent luminescence converter for NIR micro‐LEDs with microarray diameters below 5 µm, which significantly exceeds the resolutions of current commercial inkjet display pixels. The findings may open new avenues for the exploration of highly efficient NIR micro‐LEDs in a variety of applications.
Improving the Photovoltaic Properties and Stability of Inverted Perovskite Solar Cells with Hydroxylamine‐Based Additives
Authors: Nagasawa Keisuke , Sano Takeshi , Chau Viet Nguyen , Enomoto Kensei , Okuyama Yutaka , Sayama Yuya , Oikawa Ryosuke , Chiba Takayuki , Kido Junji 
Published: December 2023

AbstractOrganic–inorganic halide perovskite solar cells (PVSCs) are considered a promising emerging photovoltaic technology that offer exceptional optoelectronic properties and the potential for economic solar energy conversion. Additive engineering‐based fabrication processes can achieve highly efficient and stable PVSCs that feature well‐controlled perovskite layers with a dense, uniform, “black” α‐phase crystal structure, as well as large grains and few defects. In this study, several hydroxylamine derivatives are introduced as additives to FAPbI3 precursor solutions to investigate their effects on the performance of PVSCs. The addition of hydroxylamine derivatives suppresses the formation of the unwanted δ‐phase and lead iodide, while the α‐phase cubic structure is preferentially formed without changing the bandgap of FAPbI3. Additionally, the additive‐treated perovskite films show improved stability compared with those without additives. Moreover, using X‐ray diffraction and X‐ray photoelectron spectroscopy analyses, it is discovered that the hydroxylamine‐based additives are not incorporated in the crystal lattices but rather resided on the surface or grain boundaries. Notably, the inverted PVSCs added with N‐methylhydroxylamine exhibit an improved power conversion efficiency, higher stability, and minimal hysteresis.
Synergistic Effect of Carbon Nanotube Yarn Hybrid Energy Harvesters Based on Mechanical Stretching and Glucose
Authors: Lee Dong Yeop , Hyeon Jae Sang , Mun Tae Jin , Moon Ji Hwan , Park Jong Woo , Kaner Richard B. , Kim Seon Jeong 
Published: December 2023

Energy harvesting, as a sustainable power source for implantable medical devices within the human body, is an intriguing area of research. The utilization of biochemical and biomechanical energy derived from the body offers a promising sustainable energy source. However, obtaining high power density in vivo is a challenge. Herein, energy harvesting is demonstrated using hybrid energy harvesters that simultaneously use mechanical energy from stretching and chemical energy from glucose. The hybrid energy harvesters operate as both biofuel cells (BFC) and mechano‐electrochemical energy harvesters (MEEH) within a single electrochemical cell. As a result, the hybrid energy harvesters offer a maximum power density of 17.8 W kg−1 and an average power density of 15.1 W kg−1. These values increase by 14.5% in maximum power density and 16.8% in average power density, compared to the sum of the power density obtained by mechanical stretching and glucose oxidation individually. Based on their improved performance and compact size, owing to the synergistic effect of the two electrochemical harvesting methods, these hybrid harvesters have the potential to be applied to implantable power sources.
Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons
Authors: Lu Zixuan , Barberio Chiara , Fernandez‐Villegas Ana , Withers Aimee , Wheeler Alexandra , Kallitsis Konstantinos , Martinelli Eleonora , Savva Achilleas , Hess Becky M. , Pappa Anna‐Maria , Schierle Gabriele S. Kaminski , Owens Róisín M. 
Published: December 2023

AbstractDrug studies targeting neuronal ion channels are crucial to understand neuronal function and develop therapies for neurological diseases. The traditional method to study neuronal ion‐channel activities heavily relies on the whole‐cell patch clamp as the industry standard. However, this technique is both technically challenging and labour‐intensive, while involving the complexity of keeping cells alive with low throughput. Therefore, the shortcomings are limiting the efficiency of ion‐channel‐related neuroscience research and drug testing. Here, this work reports a new system of integrating neuron membranes with organic microelectrode arrays (OMEAs) for ion‐channel‐related drug studies. This work demonstrates that the supported lipid bilayers (SLBs) derived from both neuron‐like (neuroblastoma) cells and primary neurons are integrated with OMEAs for the first time. The increased expression of voltage‐gated calcium (CaV) ion channels on differentiated SH‐SY5Y SLBs compared to non‐differentiated ones is sensed electrically. Also, dose‐response of the CaV ion‐channel blocking effect on primary cortical neuronal SLBs from rats is monitored. The dose range causing ion channel blocking is comparable to literature. This system overcomes the major challenges from traditional methods (e.g., patch clamp) and showcases an easy‐to‐test, rapid, ultra‐sensitive, cell‐free, and high‐throughput platform to monitor dose‐dependent ion‐channel blocking effects on native neuronal membranes.
Design and Engineering of Light‐Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity
Authors: Sun Yangning , Chen Qi , Cheng Yanbing , Wang Xi , Deng Zixin , Zhou Fuling , Sun Yuhui 
Published: December 2023

AbstractBase editors, which enable targeted locus nucleotide conversion in genomic DNA without double‐stranded breaks, have been engineered as powerful tools for biotechnological and clinical applications. However, the application of base editors is limited by their off‐target effects. Continuously expressed deaminases used for gene editing may lead to unwanted base alterations at unpredictable genomic locations. In the present study, blue‐light‐activated base editors (BLBEs) are engineered based on the distinct photoswitches magnets that can switch from a monomer to dimerization state in response to blue light. By fusing the N‐ and C‐termini of split DNA deaminases with photoswitches Magnets, efficient A‐to‐G and C‐to‐T base editing is achieved in response to blue light in prokaryotic and eukaryotic cells. Furthermore, the results showed that BLBEs can realize precise blue light‐induced gene editing across broad genomic loci with low off‐target activity at the DNA‐ and RNA‐level. Collectively, these findings suggest that the optogenetic utilization of base editing and optical base editors may provide powerful tools to promote the development of optogenetic genome engineering.
Manganese Enhances the Osteogenic Effect of Silicon‐Hydroxyapatite Nanowires by Targeting T Lymphocyte Polarization
Authors: Li Ruomei , Zhu Zhiyu , Zhang Bolin , Jiang Ting , Zhu Cheng , Mei Peng , Jin Yu , Wang Ruiqing , Li Yixin , Guo Weiming , Liu Chengxiao , Xia Lunguo , Fang Bing 
Published: December 2023

AbstractBiomaterials encounter considerable challenges in extensive bone defect regeneration. The amelioration of outcomes may be attainable through the orchestrated modulation of both innate and adaptive immunity. Silicon‐hydroxyapatite, for instance, which solely focuses on regulating innate immunity, is inadequate for long‐term bone regeneration. Herein, extra manganese (Mn)‐doping is utilized for enhancing the osteogenic ability by mediating adaptive immunity. Intriguingly, Mn‐doping engenders heightened recruitment of CD4+ T cells to the bone defect site, concurrently manifesting escalated T helper (Th) 2 polarization and an abatement in Th1 cell polarization. This consequential immune milieu yields a collaborative elevation of interleukin 4, secreted by Th2 cells, coupled with attenuated interferon gamma, secreted by Th1 cells. This orchestrated interplay distinctly fosters the osteogenesis of bone marrow stromal cells and effectuates consequential regeneration of the mandibular bone defect. The modulatory mechanism of Th1/Th2 balance lies primarily in the indispensable role of manganese superoxide dismutase (MnSOD) and the phosphorylation of adenosine 5′‐monophosphate‐activated protein kinase (AMPK). In conclusion, this study highlights the transformative potential of Mn‐doping in amplifying the osteogenic efficacy of silicon‐hydroxyapatite nanowires by regulating T cell‐mediated adaptive immunity via the MnSOD/AMPK pathway, thereby creating an anti‐inflammatory milieu favorable for bone regeneration.
Takotsubo cardiomyopathy secondary to electroconvulsive therapy in a young adult with Down syndrome regression disorder
Authors: Ortega María del Carmen , Bullard José Pablo , del Mar Unceta María , Sánchez‐Pedreño Felipe Ortuño , Molero Patricio , de Asúa Diego Real 
Published: December 2023

AbstractWe report the case of an 18‐year‐old woman with Down syndrome (DS) who developed Takotsubo cardiomyopathy (TSC) immediately after the administration of electroconvulsive therapy (ECT), a treatment prescribed for Down syndrome regression disorder resistant to oral psychotropic drugs. TSC is a nonischemic cardiomyopathy related to psychological or physical stress, which has been described as a rare complication of ECT (Kinoshita et al., 2023, Journal of Electroconvulsive Therapy, 39, 185–192). The clinical description of the case is accompanied by a discussion of the peculiarities of the autonomic nervous system in DS.
Spouses of individuals living with mild cognitive impairment or dementia in the United States: A descriptive, population‐based study
Authors: Torres Jacqueline M. , Flores Romero Karla Renata , Kotwal Ashwin A. , Chen Ruijia , Hill‐Jarrett Tanisha , Mitchell Uchechi A. , Glymour Medellena Maria 
Published: December 2023

AbstractBACKGROUNDLittle is known about the population of individuals who live with a spouse with cognitive impairment (CI) or dementia.METHODSUsing the US Health and Retirement Study, 2000 to 2018, we estimated the population of adults ≥ 50 years old co‐residing with a spouse with probable CI/dementia. We described their socio‐demographic and health characteristics and quantified socio‐demographic inequities.RESULTSAmong community‐dwelling adults ≥ 50 years old, 6% of women and 4% of men co‐resided with a spouse with probable CI/dementia. Among those who were married/partnered, the prevalence of spousal dementia was greater for Black and Hispanic adults compared to their White counterparts, and for those with lower versus higher educational attainment. Among spouses, activities of daily living disability, depression, and past 2‐year hospitalization was common.DISCUSSIONMillions of older adults, disproportionately Black and Hispanic people and people with lower levels of educational attainment, live with a spouse with CI while also facing their own major health challenges.
When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia
Authors: Biesbroek J. Matthijs , Verhagen Marieke G. , van der Stigchel Stefan , Biessels Geert Jan 
Published: December 2023

AbstractThe thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and “gateway to the cortex” has expanded in recognition of its role as a central integrator of inputs from sensory systems, cortex, basal ganglia, limbic systems, brain stem nuclei, and cerebellum. As such, the thalamus is critical for numerous aspects of human cognition, mood, and behavior, as well as serving sensory processing and motor functions. Thalamus pathology is an important contributor to cognitive and functional decline, and it might be argued that the thalamus has been somewhat overlooked as an important player in dementia. In this review, we provide a comprehensive overview of thalamus anatomy and function, with an emphasis on human cognition and behavior, and discuss emerging insights on the role of thalamus pathology in dementia.
One‐step hydrothermal preparation of chiral carbon quantum dots and enantioselective sensing of glutamine enantiomeric isomers
Authors: Li Xiang , Wu Jun , Zhu Xiashi 
Published: December 2023

AbstractA novel method for chiral identification of glutamine enantiomers based on chiral carbon quantum dots (cCQDs) fluorescent probes. cCQDs were prepared using a one‐step hydrothermal method with L‐tryptophan as the carbon source and chiral source, producing spherical nanoparticles exhibiting a blue colour luminescence. The fluorescence intensity (F) of cCQDs was enhanced or quenched following the addition of chiral enantiomeric glutamine (L/D‐Gln), and therefore cCQDs, as a fluorescence probe, could be used for enantioselective sensing of the L/D‐Gln. The fluorescence enhancement value (∆FE) exhibited good linearity with L‐Gln concentration in the range 0.23–10.00 mM, and the limit of detection was 0.14 mM. The fluorescence quenching value (∆FQ) showed a good linear relationship with D‐Gln concentration in the range 0.29–10.00 mM, and the detection limit was 0.18 mM. The mechanism of fluorescence enhancement/quenching was explored by molecular modelling and the type of quenching. The method was applied to the determination of L‐Gln content in real samples, and the recovery rate was satisfactory. This study provided a novel approach for the synthesis of cCQDs and the recognition of amino acid enantiomers.
Improvement of gelation properties of indica rice flour with stabilized rice bran from different thermal treatment
Authors: Li Jia , Liu Chun , Wu Na‐Na , Tan Bin 
Published: December 2023

AbstractBackground and ObjectivesRice bran is enriched with bioactive compounds, which makes it more competitive as a functional food raw material. The stabilization of rice bran can inhibit the activity of endogenous enzymes, reduce its oxidation sensitivity, and change its physical and chemical properties, providing more possibilities for its application in the food industry. In this study, rice bran from five stabilization treatments (atmospheric pressure cooking, high‐pressure cooking, atmospheric steam, microwave heating, and extrusion cooking) were investigated for their effect on the gel properties of indica rice flour.FindingsStabilized rice bran could enhance the hydration properties and increase the enthalpy value of rice flour. The gelatinization properties indicated that the viscosity and fluidity of the rice paste were increased, and the aggregation and rearrangement of rice starch were promoted. From the rheological properties, stabilized rice bran enhanced the viscoelasticity of the rice flour gel. In addition, the stabilized rice bran could also reduce the yield of freeze‐thawing water of the rice flour gel. Rice bran with thermal treatments can significantly improve the gel properties of indica rice flour.ConclusionsIndica rice flour mixed with stabilized rice bran showed significant improvements in hydration, gelatinization, rheological properties, and freeze‐thaw stability.Significance and NoveltyIt is potential for the application of the gel from rice flour with stabilized rice bran in the starch‐based food industry.
Selective serotonin reuptake inhibitors during pregnancy and lactation: A scoping review of effects on the maternal and infant gut microbiome
Authors: Desorcy‐Scherer Katelyn , Fricke Hannah P. , Hernandez Laura L. 
Published: December 2023

AbstractPerinatal mood disorders are a tremendous burden to childbearing families and treatment with selective serotonin reuptake inhibitor (SSRI) antidepressants is increasingly common. Exposure to SSRIs may affect serotonin signaling and ultimately, microbes that live in the gut. Health of the gut microbiome during pregnancy, lactation, and early infancy is critical, yet there is limited evidence to describe the relationship between SSRI exposure and gut microbiome status in this population. The purpose of this Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA)‐compliant scoping review is to assess evidence and describe key concepts regarding whether SSRI exposure affects the maternal and infant gut microbiome. Sources were collected from PubMed, Web of Science, and Scopus databases, and an additional gray literature search was performed. Our search criteria returned only three sources, two rodent models and one human subjects research study. Results suggest that fluoxetine (SSRI) exposure may affect maternal gut microbiome dynamics during pregnancy and lactation. There were no available sources to describe the relationship between perinatal SSRI exposure and the infant gut microbiome. There is a significant gap in the literature regarding whether SSRI antidepressants affect the maternal and infant gut microbiome. Future studies are required to better understand how SSRI antidepressant exposure affects perinatal health.
Development and practice of learning materials for an engineering oriented circuit design workshop for elementary school student
Authors: Ishibashi Tadashi , Moriyama Jun 
Published: December 2023

AbstractThis study aimed to develop teaching materials for circuit design and fabrication for elementary school students, and conduct workshops oriented to engineering. First, the content of the circuit design workshop was discussed and it was determined that a connection‐focused design would be appropriate. Second, we examined the issue of existing teaching materials. Many of the existing kit materials were not suitable for learning circuit design as it was already completed. In addition, many of them required soldering work, which was too difficult for elementary school students. Hands‐on materials that allow students to construct circuits through trial and error were suitable for learning circuit design. Therefore, we developed design and fabrication support materials using a 3D printer and conductive tape. Next, we provided workshop opportunities using developed material, with the theme of “making light‐up cards,” wherein elementary school students worked on designing the layout of the components and fabrication. Consequently, students’ conceptual understanding of the connection was improved. All students were able to complete the circuit, with high self‐evaluations of satisfaction and understanding suggesting that the activity was engineering‐oriented.
Study of humidity sensor using α‐Fe2O3 as a humidity‐sensitive material
Authors: Naito Kosuke , Sasaki Kyohei , Ikenaga Noriaki 
Published: December 2023

AbstractIn this study, iron oxide thin films are prepared under various heat treatment conditions, and their crystal structures and moisture‐sensitive characteristics were evaluated to clarify the usefulness of iron oxide thin films as humidity‐sensitive materials for humidity sensors. In addition, the possibility of a humidity sensor with a wide dynamic range was investigated by evaluating the relationship between the film thickness of the iron oxide thin film, the electrode width of the device, and the humidity‐sensitive characteristics. As a result, it was found that the crystal structure of α‐Fe2O3 exhibits relatively good humidity sensitivity compared to other crystal structures, and that the sensitivity to humidity can be adjusted by appropriately selecting the electrode width and film thickness of the device. Therefore, the α‐Fe2O3 thin film may be useful as a moisture‐sensitive material for wide dynamic range humidity sensors by appropriately adjusting the film thickness and electrode width.