bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Infrasound Sensor Calibration and Characterization
Authors: Fee David , Merchant Bion John 
Published: February 2024

Abstract
Previous testing has shown that infrasound sensors deployed in the field can exhibit notable deviations from their nominal, lab-based calibrations. These variations may be due to changes in environmental conditions, long-term sensor drift, or other unresolved features. In early 2018, we installed two identical infrasound elements with five infrasound sensors at each element (Chaparral M50A, Chaparral M64LN, CEA/Martec MB2005, CEA/Seismowave MB3a, and Hyperion IFS-5113A). These sensors were accepted or under consideration for use in the International Monitoring System network of the Comprehensive Nuclear-Test-Ban Treaty. Each element had all sensors connected to a single digitizer and port to the atmosphere. We also recorded instrument enclosure air temperature and humidity and external air temperature. Using the MB2005 as the reference, we examine the relative sensor response (both magnitude and phase) as a function of time and frequency and compare it with quarterly laboratory calibrations and environmental conditions. We find that the magnitude response for all sensors exhibits some variability in both the lab and field, with the amplitude variations often &gt;5%. The field-based variations are more severe and occur on both long-term (months) and short-term (hours) timescales. Short-term variability correlates with changes in environmental conditions and is considerable (up to 25%) for the Chaparral M50A and noticeable (∼5%) for the French Alternative Energies and Atomic Energy Commission (CEA) MB3a. Long-term magnitude variability for the Chaparral M50A was up to 50% and does not clearly correlate with environmental conditions. The other sensors show some long-term magnitude offsets, but they have relatively stable responses in the conditions we examined. The MB3a also displays some frequency-dependent magnitude variability and shows a minor dependence on temperature. Phase estimates are stable and near zero for all sensors tested. These results strongly suggest sensor response and variability due to environmental conditions should be considered in future infrasound data interpretation and sensor selection and development.
Management of Primary Hyperhidrosis With <i>Patolakaturohinyadi Kashayam</i> and <i>Shireeshadi Choornam</i> (<i>Avachoornana</i>) – A Case Report
Authors: Deepthikrishna G. , Soman Devipriya 
Published: February 2024

ABSTRACT
Primary focal hyperhidrosis (primary hyperhidrosis) is a pathological disorder characterised by excessive sweating in the local sites such as the palmar surface of the hands, axillae, soles and face to a degree that interferes with daily life in affected persons. This case report brings into light an innovative management of Primary Hyperhidrosis. Ayurvedic formulations such as Patolakaturohinyadi Kashayam for internal use and Shireeshadi Choornam as Avachoornana for external use were administered for this condition. After 35 days, the patient was re-examined and there was a significant change in Transepidermal Water Loss (TEWL hydration values and Hyperhidrosis Disease Severity Scale (HDSS) and Hyperhidrosis Quality of Life (HidroQOL) scores.
Perspectivas multimetodológicas de investigaciones en educación científica: Una revisión desde dimensiones paradigmáticas
Authors: Lorduy Danny 
Published: February 2024

Este artículo tuvo como objetivo analizar los aportes de investigaciones desde perspectivas multimetodológicas y dimensiones paradigmáticas que permitan auspiciar estudios sinérgicos y sistémicos en educacióncientífica. El tipo de investigación propuesto fue mixto, de diseño no experimental y nivel transversal descriptivo simple, mediante una revisión sistemática de literatura (RSL) utilizando estudios epistemológicos y protocolos de metaanálisis según PRISMA en diferentes fuentes de datos internacionales entre el 2000-2020. La calidad general (Cg) de la búsqueda se obtuvo con un índice de confianza del 95% mediante una lista de verificación PRISMA einstrumento de evaluación de ítems de las publicaciones. Los resultados obtenidos dan cuenta de un insuficiente reporte de investigaciones multimetodológicas desde las dimensiones paradigmáticas ontológicas, epistemológicas, metodológicas y tecnológicas. Las veintidós publicaciones primarias son principalmente teóricas, esto quiere decir que utilizan metodologías que requieren más validación empírica para ser aceptadas. A partir de estos resultados se abre un importante panorama hacia futuras investigaciones en este campo, permitiendo consolidar la construcción de una teoría sustantiva que explicite nuevas formas de investigar en educación científica, debido a que, por su naturaleza compleja, generalmente, no encuentran respuestas satisfactorias desde enfoques individuales.
Invasion Alters Plant and Mycorrhizal Communities in an Alpine Tussock Grassland
Authors: Moyle Darby M , Deslippe Julie R 
Published: February 2024

Abstract

Plant invasions now impact even the world’s most remote ecosystems, including alpine zones, altering key mutualisms that affect ecosystem functions. Plant-mycorrhizal associations can be sensitive to invasion, but previous studies have been limited in the types of mycorrhizas examined, favouring invaders that host arbuscular mycorrhizas or are non-mycorrhizal. Consequently, little is known about how invaders that host other types of mycorrhizas may affect community and ecosystem properties. We studied invasion by an ericoid mycorrhizal host plant (Calluna vulgaris L., heather) in alpine tussock grasslands in New Zealand. We investigate the effects of increasing C. vulgaris density on the plant and soil microbial community and on mycorrhization in the dominant native species (Chionochloa rubra Z., red tussock), an arbuscular mycorrhizal host. We show that variation in plant community composition among sites was driven by C. vulgaris density. Higher densities of C. vulgaris were associated with a reduced diameter of C. rubra plants and lower densities of neighbouring plant species, especially woody shrubs. Belowground, we show that higher densities of C. vulgaris were associated with lower rates of mycorrhization in native C. rubra and higher abundances of the fungal fatty acid methyl ester (FAME) biomarker but had little effect on the total microbial community biomass, suggesting that increased ericoid mycorrhizal fungal biomass increased the ratio of fungi relative to bacteria in high C. vulgaris density stands. By exploring invasion of a plant with an atypical mycorrhizal type, our study expands knowledge of the ecosystem consequences of biological invasions.
Peripheral skin cooling during Hypergravity: Neuroendocrine, leucocytic and hematological reactions
Authors: Nordine Michael , Kagelmann Niklas , Kloka Jan , Gunga Hanns-Christian , Heinz Viktor , Pilz Niklas , Opatz Oliver , Bothe Tomas 
Published: February 2024

Abstract
Introduction:
Optimal neuroendocrine responses, particularly noradrenergic responses, are critical during hypergravity (+ Gz) exposure. Peripheral skin cooling (PSC) has the potential to enhance noradrenergic function, which could improve + Gz resiliency and may also affect leukocyte and hematologic factors. We predicted that PSC would augment cumulative + Gz stress index (CGSI) neuroendocrine, leukocyte and hematologic activity compared to controls, and that CGSI would shift to a noradrenergic dependency in PSC compared to controls.
Methods
18 men in a cross-over design underwent a graded + Gz profile. PSC was applied using Arctic Sun cooling pads around the thighs with 8°C water infusion. Neuroendocrine parameters and a complete blood profile with differential were obtained before and after + Gz. CGSI was calculated as + Gz * seconds. Pre / post comparisons were made within the groups with paired t-tests and between groups with independent t-tests. Pearson's correlation analysis was performed between CGSI and neuroendocrine/leukocyte/hematological parameters.
Results
CSGI did not differ between groups. In both groups, all neuroendocrine, leukocyte and hematological factors changed significantly from pre to post + Gz, except for serum osmolality, which increased only in PSC (p = 0.03). In PSC, CGSI correlated with noradrenaline (p < 0.01, r = 0.71), metanephrine (p = 0.02, r = -0.54), neutrophiles (p = 0.03, r = 0.51), and thrombocytes (p = 0.04, r = 0.48), while in controls, CGSI correlated with metanephrine (p = 0.02, r = -0.54). Pre + Gz metanephrine correlated with CGSI in both groups.
Discussion
PSC did not confer a higher CGSI nor induce a greater neuroendocrine, leukocytic or hematologic response compared to controls. However, the increase in serum osmolality may indicate increased vasopressin activity. The strong correlations between CGSI and norepinephrine in PSC suggest that despite equal average serum levels, the responsiveness of norepinephrine is enhanced. This may serve as an optimal cardio-protective countermeasure for manned space missions and possible ICU patients. The correlations between neutrophiles and thrombocytes in PSC suggest a leukocytic and hematologic involvement in CSGI. In addition, this is the first study to demonstrate that baseline serum metanephrine may serve as a potential neuroendocrine parameter to assess + Gz resilience.
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Authors: Romeo Stefano , Jamialahmadi Oveis , De Vincentis Antonio , Tavaglione Federica , Malvestiti Francesco , Li-Gao Ruifang , Mancina Rosellina , Alvarez Marcus , Gelev Kyla , Maurotti Samantha , Vespasiani-Gentilucci Umberto , Rosendaal Frits , Kozlitina Julia , Pajukanta Päivi , Pattou François , Valenti Luca 
Published: February 2024

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses an excess of triglycerides in the liver, which can lead to cirrhosis and liver cancer. While there is solid epidemiological evidence of MASLD coexisting with cardiometabolic disease, several leading genetic risk factors for MASLD do not increase the risk of cardiovascular disease, suggesting no causal relationship between MASLD and cardiometabolic derangement. In this work, we leveraged measurements of visceral adiposity and identified 27 novel genetic loci associated with MASLD. Among these loci, we replicated 6 in several independent cohorts. Next, we generated two partitioned polygenic risk scores (PRS) based on the mechanism of genetic association with MASLD encompassing intra-hepatic lipoprotein retention. The two PRS suggest the presence of at least two distinct types of MASLD, one confined to the liver resulting in a more aggressive liver disease and one that is systemic and results in a higher risk of cardiometabolic disease.
Characteristics and Outcomes of Patients Screened by the Rapid Response Team and Transferred to Intensive Care Unit in South Korea
Authors: Nam Yunha , Kang Byung Ju , Hong Sang-Bum , Jeon Kyeongman , Lee Dong-Hyun , Kim Jung Soo , Park Jisoo , Lee Sang-Min , Lee Song I 
Published: February 2024

Abstract

Background
The rapid response system (RRS) is associated with a reduction in in-hospital mortality. This study aimed to determine the characteristics and outcomes of patients transferred to the intensive care unit (ICU) by a rapid response team (RRT).
Methods
This retrospective, multicenter cohort study included patients from nine hospitals in South Korea. Adult patients who were admitted to the general ward (GW) and required RRS activation were included. Patients with do-not-resuscitate (DNR) orders and without lactate level or Sequential Organ Failure Assessment (SOFA) score were excluded.
Results
A total of 8,228 patients were enrolled, 3,379 were transferred to the ICU. The most common reasons for RRT activation were respiratory distress, sepsis and septic shock. The number of patients who underwent intervenions, the length of hospital stay, 28-day mortality, and in-hospital mortality were higher in the ICU group than in the GW group. Factors that could affect both 28-day and in-hospital mortality included the severity score, low PaO2/FiO2 ratio, higher lactate and C-reactive protein (CRP) levels, and hospitalization time prior to RRT activation.
Conclusion
ICU transfer after RRT activation does not significantly affect patient outcomes, highlighting the need for more individualized patient assessments to better individualize ICU transfer and related interventions.
Combination of multiple omics and machine learning identifies diagnostic genes for ARDS and COVID-19
Authors: Tian Chuanxi , Guo Yikun , Guan Huifang , Ma Kaile , Hao Rui , Zhu Wei , Zhao Jinyue , Li Min 
Published: February 2024

Abstract

BACKGROUND
Acute respiratory distress syndrome (ARDS) is a common acute clinical syndrome of the respiratory system with a high mortality rate and difficult prognosis.COVID-19 is a serious respiratory infectious disease caused by coronaviruses in a global pandemic. Some studies have suggested a possible association between COVID-19 and ARDS, but few studies have investigated the mechanism of interaction between them.
METHODS
Microarray data of ARDS (GSE32707 and GSE66890) and COVID-19 (GSE213313) were downloaded from the GEO database and searched for common differential genes for enrichment analysis.WGCNA was used to identify co-expression modules and genes associated with ARDS and COVID-19. RF and LASSO were performed for candidate gene identification. Machine learning XGBoost improved the diagnosis of hub genes in ARDS and COVID-19. The degree of immune cell infiltration in ARDS and COVID-19 samples was assessed using the CIBERSORT algorithm, and the relationship between hub genes and infiltrating immune cells was investigated. Changes in pathway activity per cell were visualized using Seurat standard flow down clustering (seurat) to visualize peripheral blood mononuclear cell (PBMC) single-cell RNA sequencing (scRNA-seq) data from patients with sepsis-combined ARDS and patients with sepsis alone.
RESULTS
Limma difference analysis identified 314 up-regulated genes and 241 down-regulated genes in ARDS and COVID-19.WGCNA identified the purple-red co-expression module as the core module of ARDS and COVID-19. Five candidate genes, namely HIST1H2BK, TCF4, OLFM4, KIF14 and HK1, were screened using two machine learning algorithms, RF and LASSO. XGBoost constructed diagnostic models to evaluate the hub genes with high diagnostic efficacy in ARDS and COVID-19. Single-cell sequencing revealed the presence of alterations in five immune subpopulations, including monocytes, B cells, T cells, NK cells and platelets, with high expression levels and cellular occupancy of TCF4 and HK1, which are involved in oxidative reactions.
Managing diabetes with nanomedicine: nanoMIL-89 as a promising drug delivery system for metformin.
Authors: Mohamed Hana , Mohamed Nura , Macasa Shantelle , Basha Hamda , Adan Adna , Marei Isra , Ding Hong , Triggle Christopher , Crovella Sergio , Abou-Saleh Haissam 
Published: February 2024

Abstract

Diabetes Mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as atherosclerosis, coronary artery disease, and hypertension. Conventional treatment methods, though effective, are often challenging, costly, and may lead to systemic side effects. This study explores the potential of nanomedicine applications, specifically Metal-Organic Frameworks (MOFs), as drug carriers to overcome these limitations. The Materials Institute Lavoisier-89 nanoparticles (nanoMIL-89) have previously demonstrated promise as a drug delivery vehicle for chronic diseases due to their anti-oxidant and cardio-protective properties. In this investigation, nanoMIL-89 was loaded with the anti-diabetic drug metformin (MET), creating MET@nanoMIL-89 formulation.
We examined the drug release kinetics of MET@nanoMIL-89 over 96 hours and assessed its impact on the viability of various endothelial cells. Furthermore, we investigated the nanoformulation effect on inflammatory markers in these cells and explored its influence on phosphorylated eNOS, total eNOS, and AKT levels. Our findings indicate that nanoMIL-89 effectively released metformin over 96 hours and caused a concentration-dependent reduction in CXCL-8 release from endothelial cells. Notably, MET@nanoMIL-89 reduced dihydroethidium levels and increased phosphorylated eNOS, total eNOS, and AKT levels.
Our results underscore the potential of nanoMIL-89 as a versatile potential drug delivery platform for anti-diabetic drugs, offering a prospective therapeutic approach for diabetic patients with associated cardiovascular complications.
Three spectrophotometric quantitative analysis of bisoprolol fumarate and telmisartan in fixed-dose combination utilizing ratio spectra manipulation methods
Authors: Sattar Osama I. Abdel , Abuseada Hamed H. M. , Ramzy Sherif , Abuelwafa Mahmoud M. 
Published: February 2024

Abstract

Hypertension is a common chronic disease that requires several treatment regimens. As a result, limiting the dosage of these medications is critical to patient compliance. Therefore, bisoprolol fumarate and telmisartan have been recently made in a fixed-dose combination rather than individual doses to manage blood pressure. Hence, the UV absorption spectra of bisoprolol fumarate and telmisartan displayed a significant overlap. Therefore, augmentation of three simple, precise, and selective spectrophotometric methods relying on manipulation of ratio spectra, specifically ratio difference, first derivative, and mean centering of ratio spectra, have been validated, described, and verified for simultaneous measurement of bisoprolol fumarate and telmisartan in pure form and their fixed dose combination. The ratio difference method relies on measuring the amplitude difference between the ratio spectra’s values at 210 and 224 nm for bisoprolol and between 255 and 265 nm for telmisartan. On the other hand, the first derivative of the ratio spectra technique is based on the measurement of amplitude signals at 232 nm and 243 nm of the derived spectra for bisoprolol and telmisartan, respectively. Furthermore, the mean centering of the ratio depends on measuring the mean-centered ratio spectra's values at 223 nm for bisoprolol and 245 nm for telmisartan. The established procedures underwent validation in compliance with ICH recommendations. The developed techniques are precise and accurate and have the potential to be successfully used for estimating bisoprolol and telmisartan in their combined dosage form.
Assessing the Association Between Nitrogen Dioxide Air Pollution and the Risk of Schizophreniar’s Disease by Integrating Multigenomics
Authors: Li Chunying , Zou Xiao 
Published: February 2024

Abstract
Nitrogen dioxide (NO2) is mainly discharged from the burning of fossil fuels, and remains suspended in the air with other particulate pollutants, which has a significant impact on the Earth's ecological environment and is harmful to human health.Schizophrenia is a nervous system disease involving emotion, thinking and behavior. There is no consistent conclusion about the etiology of schizophrenia, though numerous of studies are ongoing. Although previous research have suggested that exposure to NO2 air pollution can increase the risk of schizophrenia, but which is still at the preliminary exploratory stage.Here we used Mendelian Randomization (MR) analysis to assess the potential relationship between NO2 air pollution exposure level and schizophrenia from the perspective of genetic variation.To ensure the reliability of the analysis results, we also did a sensitivity analysis.All analysis results show that there is a significant causal relationship between NO2 exposure level and schizophrenia risk,which can help advance the search for the causes of schizophrenia.
Optimal Timing for Atrial Fibrillation Patients to Undergo Catheter Ablation: Insights from Long-Term Outcome Studies
Authors: Lin Mingjie , Rong Bing , Zhang Kai , Chen Tongshuai , Wang Juntao , Han Wenqiang , Li Yihan , Chen Changli , Zhong Jingquan , Wu Lin 
Published: February 2024

Abstract

Background Despite catheter ablation being an established treatment for atrial fibrillation (AF), optimal timing for this procedure to improve long-term outcomes remains uncertain.
Objective To investigate the impact of diagnosis-to-ablation time (DAT) on AF recurrence and major adverse cardiovascular and cerebrovascular events (MACCE) following catheter ablation.
Methods This study retrospectively analyzed prospective observational data from a single center, including 2,097 participants undergoing AF ablation between January 2016 and December 2020. Baseline characteristics, clinical outcomes, and the incidence of MACCE were evaluated. Patients were stratified by DAT: ≤ 1 year, > 1 to ≤ 3 years, and > 3 years. Cox proportional hazards and logistic regression analyses were used to identify predictors of AF recurrence and MACCE
Results During the 46.89 ± 16.46 months follow-up, AF recurred in 512 patients (24.6%). Early intervention (DAT ≤ 1 year or ≤ 3 years) corresponded with higher AF-free survival, particularly in patients with persistent AF (HR reference to DAT ≤ 1 year: 1.548 [95%CI: 1.139–2.102]). Patients with DAT > 3 years had higher risks of AF recurrence within two years, but long-term recurrence rates stabilized across DAT groups. Left atrial diameter ≥ 40 mm and female gender were identified as independent predictors of AF recurrence. The overall impact of DAT on MACCE occurrence was not significant, with age and vascular disease being independent predictors.
Conclusions Early catheter ablation is preferable for maintaining sinus rhythm, particularly in persistent AF. However, DAT did not influence the incidence of MACCE. These findings endorse the paradigm shift towards early ablation but also emphasize the importance of personalized treatment strategies based on individual patient profiles.
Near-infrared stimuli-responsive hydrogel mechanically and biologically promote cell migration for accelerating diabetic wound healing
Authors: Zhao Weijing , Qiang Lei , Zhang Changru , Li Shuai , Liu Yihao , Wang Chengwei , Ma Xiaojun , Wang Jinwu , Bao Yuqian 
Published: February 2024

Abstract
Diabetic wound healing including diabetic foot ulcers is a major clinical challenge, which could bring increased level of mortality and morbidity. However, conventional wound dressings exhibit limited healing efficacy due to their lack of active modulation for healing process. Here, a near-infrared (NIR) stimuli-responsive composite hydrogel dressing with the synergistic effect of both mechanical contraction and epithelial-mesenchymal transition (EMT) was developed to facilitate the cell migration and vascularization for diabetic wound healing. In the methacrylated gelatin (GelMA)-based composite hydrogel, N-isopropylacrylamide (NIPAM) and polydopamine nanoparticles (PDA NPs) were incorporated to endowed the composite hydrogel with thermosensitive and photothermal properties. Linagliptin (LIN) was loaded into the composite hydrogel and the drug release rate could be controlled by NIR laser irradiation. NIR triggered on-demand active contraction of wound area and LIN release for biological stimulation were potentially realized in this responsive system due to the thermally induced sol-gel transition of composite hydrogel. The release of loaded LIN could effectively promote the cell migration by activating EMT and enhance the angiogenesis. In the full-thickness skin defect model, the LIN-loaded composite hydrogel with NIR laser irradiation had the highest wound close rate as compared with pure hydrogel and LIN-loaded hydrogel groups. Therefore, this composite hydrogel can be served as an excellent platform for promoting wound healing and will find more practical value in clinical treatment.