bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alfuzosin-Induced Acute Hepatitis in a Patient with Chronic Liver Disease
Authors: Yolcu Ömer Faruk , Köklü Seyfettin , Köksal Aydin Ş , Yüksel Osman , Beyazit Yavuz , Başar Ömer 
Published: July 2004

OBJECTIVE: To report a new case of probable alfuzosin-induced hepatitis. CASE SUMMARY: An 80-year-old man was evaluated because of jaundice and pruritus. He was diagnosed as having Child-Pugh A chronic liver disease due to hepatitis B virus. Other etiologies of hepatitis were appropriately ruled out, and the hepatitis B was non-replicative. Therefore, elevated liver enzyme levels were ascribed to alfuzosin treatment. DISCUSSION: Although alfuzosin-related mixed-type hepatotoxicity has been previously reported, this is the first published case describing probable hepatocellular-type hepatotoxicity resulting from use of alfuzosin in a patient with underlying chronic liver disease. According to the Naranjo probability scale, alfuzosin was a probable cause of the hepatotoxicity. The mechanism of alfuzosin-induced liver damage is unknown. Several features, such as absence of predictable dose-dependent toxicity of alfuzosin in previous studies and absence of hypersensitivity manifestations in our case, are suggestive of a metabolic type of idiosyncratic toxicity. CONCLUSIONS: Alfuzosin rarely causes hepatotoxicity; however, clinicians must be alert for this adverse effect while using alfuzosin.
Fatal Venous Thromboembolism Associated with Antipsychotic Therapy
Authors: Farah Raymond E , Makhoul Nicola M , Farah Rola E , Shai Moshe D 
Published: July 2004

OBJECTIVE: To describe the occurrence of pulmonary embolism (PE) as a rare adverse effect of clozapine that is treatable, but sometimes fatal, and survey the literature on the subject in the hope of increasing awareness of the potential danger that may result from drug interactions. CASE SUMMARY: A 47-year-old woman treated with clozapine and paroxetine was admitted to the hospital with dyspnea and swelling of the leg. The patient was diagnosed as having PE and was treated with intravenous heparin. On hospital day 7, sudden acute respiratory failure developed and the patient died. Postmortem examination confirmed the existence of massive PE. DISCUSSION: The woman had no identifiable risk factors other than receiving a combination of clozapine and paroxetine, with a demonstrated elevated clozapine blood concentration. Use of the Naranjo probability scale revealed a probable likelihood that the adverse reaction was drug related. CONCLUSIONS: The association of antipsychotic drugs and venous thromboembolism has been previously described, but is still a rare finding. This case highlights the importance of monitoring and possibly discontinuing treatment when venous thrombosis is suspected. There should be careful monitoring, especially in patients with risk factors for thrombosis. Finally, antidepressant—antipsychotic drug combinations can increase the risk of rare adverse effects, such as venous thromboembolism, even in the absence of other risk factors.
A patient with Prader–Willi syndrome and a supernumerary marker chromosome r(15)(q11.1‐13p11.1)pat and maternal heterodisomy
Authors: Werner Marion , Ben‐Neriah Ziva , silverstein Shira , Lerer Israela , Dagan Yudith , Abeliovich Dvorah 
Published: July 2004

AbstractWe report on a Prader–Willi patient with a de novo supernumerary marker chromosome (SMC) in 16% of the cells. The SMC was a ring chromosome and it included the PWS/AS critical region as was demonstrated by FISH. Segregation analysis indicated that the SMC originated from a paternal chromosome 15 and the two normal chromosomes 15 of the patients were of the maternal homologues. Namely, the patient had maternal heterodisomy in 85% of the cells and triplication of the PWS/AS region in 15% of the cells. The Prader–Willi features were the result of the low mosaicism of the SMC. The evolution of the maternal heterodisomy and the SMC were two unrelated events, the occurrence of both events in the same embryo rescued it from lethality. © 2004 Wiley‐Liss, Inc.
Paternal uniparental disomy of chromosome 14: Confirmation of a clinically‐recognizable phenotype
Authors: Stevenson David A. , Brothman Arthur R. , Chen Zhong , Bayrak‐Toydemir Pinar , Longo Nicola 
Published: July 2004

AbstractWe report on a girl with a dicentric chromosome 14 [45,XX,inv(9)(p11q13),dic(14;14)(p11.1;p11.1)] with paternal uniparental disomy (UPD) for chromosome 14. Clinical findings include severe hypotonia, thoracic dystrophy, diastasis recti, swallowing difficulties with aspiration, developmental delay, and multiple minor anomalies. UPD for chromosome 14 has been documented with paternal UPD much less commonly than with maternal UPD. There have been ten cases of paternal UPD for chromosome 14 and one case of segmental paternal isodisomy of chromosome 14. Many of the findings are nonspecific, but the radiographic rib findings (referred to as the “coat‐hanger” sign) are characteristic for this condition. UPD 14 studies should be performed in children thought to have Jeune asphyxiating thoracic dystrophy or other related osteochondrodysplasias when the diagnosis is in question. Our patient and the previously reported cases support a discrete recognizable phenotype for paternal UPD for chromosome 14. © 2004 Wiley‐Liss, Inc.
Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population
Authors: Brown Abraham M. , Gordon Derek , Lee Hsinhwa , Caudy Michael , Hardy John , Haroutunian Vahram , Blass John P. 
Published: July 2004

AbstractAbundant biochemical evidence links deficient activity of mitochondrial α‐ketoglutarate dehydrogenase with neuropathologically confirmed Alzheimer's disease (AD). Reduced α‐ketoglutarate dehydrogenase activity has also been associated with anti‐mortem measures of clinical disability. One of the genes encoding this complex, namely, DLD, lies within a chromosome 7 region that is in linkage disequilibrium with AD. We therefore examined the hypothesis that variation in DLD is associated with AD risk. Denaturing HPLC was used to search for sequence variations in the coding and flanking regions of all exons of DLD, but no abundant variants that alter protein sequence were found. However, four common SNPs were identified and genotyped in a case‐control series of 297 Caucasians from New York City, including 229 residents of a Jewish nursing home. Logistic regression analysis was performed for the four‐locus DLD genotype, sex, and ApoE4 status to determine the association of these independent variables with AD. Significant associations with AD were observed for ApoE4 (P < 10−6) and sex combined with DLD genotype (P = 0.013). The association with the DLD genotypes appears only in the male population in both the Caucasian series (P = 0.0009, n = 83) and the Ashkenazi Jewish subseries (P = 0.017, n = 49). The DLD genotype appears to operate independently of APOE in conferring AD risk. © 2004 Wiley‐Liss, Inc.
Osteoarchaeological evidence for leprosy from western Central Asia
Authors: Blau Soren , Yagodin Vadim 
Published: July 2004

AbstractPublished reports of palaeopathological analyses of skeletal collections from Central Asia are, to date, scarce. During the macroscopic examination of skeletal remains dating to the early first millennium AD from the Ustyurt Plateau, Uzbekistan, diagnostic features suggestive of leprosy were found on one individual from Devkesken 6. This adult female exhibited rhinomaxillary changes indicative of leprosy: resorption of the anterior nasal spine, rounding and widening of the nasal aperture, erosion of the alveolar margin, loss of a maxillary incisor, and inflammatory changes in the hard palate. While it is unclear whether the bones of the hands and the feet from this individual were absent as a result of collection strategy or poor preservation, lesions affecting the tibia and fibula were recorded, and the ways in which they may be related to a diagnosis of leprosy are discussed. This is the first skeletal evidence of leprosy from Central Asia and raises questions not only about the spread of the disease in the past, but also about the living conditions of what traditionally were thought of as nomadic peoples. Am J Phys Anthropol 126:150–158, 2005. © 2004 Wiley‐Liss, Inc.
Genotype determines phenotype in experimental Lyme borreliosis
Authors: Pachner Andrew R. , Dail Donna , Bai Yunhong , Sondey Marie , Pak Lena , Narayan Kavitha , Cadavid Diego 
Published: July 2004

AbstractBorrelia burgdorferi sensu lato, the causative organism of Lyme borreliosis, is a heterogeneous group of spirochetes, consisting of at least three pathogenic species. To test the hypothesis that the genetic heterogeneity is the reason for the clinical differences, we investigated whether the experimental disease induced by European isolates is different from that induced by American isolates. Two American isolates of species B. burgdorferi sensu stricto were compared with three European isolates, two of species B. garinii, and one of species B. afzelii. The patterns of infection, immunity, and inflammation induced by the different species was distinctive. Inflammatory cells and levels of antibody in B. garinii– and B. afzelii–infected animals were lower than in B. burgdorferi s.s.–infected animals, whereas levels of spirochetal infection in the skin and nervous system were higher in the former group of animals. These data demonstrate that B. burgdorferi s.s. strains are more infective and inflammatory, whereas B. garinii and B. afzelii strains can survive the adaptive immune response to a greater degree and persist at greater numbers in the skin and nervous system. The results explain to a large extent the disparities between LNB in humans in the United States and Europe. Ann Neurol 2004
Syntheses and biological activities of polymers containing methacryloyl‐2‐oxy‐1,2,3‐propanetricarboxylic acid or 5‐fluorouracil
Authors: Lee Sun‐Mi , Lee Neung‐Ju , Ha Chang‐Sik , Cho Won‐Jei 
Published: July 2004

AbstractA series of novel copolymers, poly(methacryloyl‐2‐oxy‐1,2,3‐propanetricarboxylic acid‐co‐exo‐3,6‐epoxy‐1,2,3,6‐tetrahydrophthalic acid) [poly(MTCA‐co‐ETAc)], poly(methacryloyl‐2‐oxy‐1,2,3‐propanetricarboxylic acid‐co‐hydrogenethyl‐exo‐3,6‐epoxy‐1,2,3,6‐tetrahydrophthalate) [poly(MTCA‐co‐HEET)], and poly(methacryloyl‐2‐oxy‐1,2,3‐propanetricarboxylic acid‐co‐α‐ethoxy‐exo‐3,6‐epoxy‐1,2,3,6‐tetrahydrophthaloyl‐5‐fluorouracil) [poly(MTCA‐co‐EETFU)], were prepared from corresponding monomers by photopolymerizations at 25°C for 48 h. The polymers were identified by FTIR, 1H‐NMR, and 13C‐NMR spectroscopies. The number‐average molecular weights of the fractionated polymers determined by GPC were in the range from 9400 to 14,900 and polydispersity indices were 1.2–1.4. The in vitro IC50 values of polymers against mouse mammary carcinoma (FM3A), mouse leukemia (P388), and human histiocytic lymphoma (U937) as cancer cell lines and mouse liver cells (AC2F) as a normal cell line were much higher compared to that of 5‐fluorouracil (5‐FU). The in vivo antitumor activities of monomers and polymers against mice bearing sarcoma 180 tumor cell line were better than those of 5‐FU. The inhibition of DNA replication and antiangiogenesis activities of MTCA and copolymers were better compared to those of 5‐FU. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 57–64, 2004
Interfacial adhesion in model bioblends
Authors: Biresaw G. , Carriere C. J. , Willett J. L. 
Published: July 2004

AbstractModel bioblends were investigated for interfacial adhesion using the asymmetric double cantilever beam (ADCB) fracture method. The model bioblends comprised two synthetic polymer components, one of which was the nonbiodegradable polymer polystyrene (PS). The second component was a synthetic biodegradable polyester, which was either polycaprolactone (PCL) or Eastar Bio Copolyester® (EBU). The critical strain energy release rate (GIc) data from the ADCB fracture experiments on the model bioblends decreased in the order: PCL/PS > EBU/PS. This was opposite to the reported order in the interfacial tension of these bioblends. It is concluded that the relative interfacial adhesion of the model bioblends was due to better compatibility in PCL/PS blends over that in EBU/PS blends. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 65–73, 2004
Design and development of low‐cost optical‐fiber sensors for temperature metrology: Process monitoring of an epoxy resin system
Authors: Degamber B. , Tetlow J. , Fernando G. F. 
Published: July 2004

AbstractThis article reports the design and deployment of two optical‐fiber temperature sensors based on the fiber Fabry–Perot etalon. The first involved the use of an extrinsic fiber Fabry–Perot sensor, but in this instance, the coefficient of thermal expansion of the reflector and/or capillary was chosen to offer a mismatch. Hence, the cavity length could increase or decrease according to the coefficient of thermal expansion of the fiber and/or capillary. For comparison, single‐mode and multimode optical‐fiber Bragg gratings were also used as temperature sensors. The Fabry–Perot sensors operated from −50 to 410°C. The accuracy of the measurements was up to ±0.5°C with a low‐cost charged‐coupling‐device spectrometer. The sensors also worked effectively in a microwave oven and in a composite panel in an autoclave. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 83–95, 2004
Potential of the luminol reaction in the sensitive detection of pesticide residues by ﬂow injection analysis
Authors: Huertas‐Pérez José Fernando , García‐Campaña Ana M. , González‐Casado Antonio , Gámiz‐Gracia Laura 
Published: July 2004

AbstractThis study presents the ﬁrst analytical application of the luminol chemiluminescence (CL) reaction for the sensitive detection of carbamate residues. Some experiments have been carried out to check the inﬂuence of the presence of traces of a N‐methylcarbamate (carbaryl) on the CL emission produced from the oxidation of luminol using different oxidants, showing a signiﬁcant enhancing effect on the CL emission when the oxidation of luminol is produced by potassium permanganate in alkaline medium, this enhancement being proportional to the carbaryl concentration. This fact has permitted the establishment of a sensitive chemiluminescence ﬂow‐injection (CL‐FIA) method for the direct determination of carbaryl. The optimization of instrumental and chemical variables inﬂuencing the CL response has been carried out by applying experimental designs. Under the optimal conditions, the CL intensity was linear for a carbaryl concentration over the range 5–100 ng/mL with a detection limit of 4.9 ng/mL. This luminol–KMnO4‐based FIA‐CL system in basic medium shows an easy, fast and cheap alternative detection mode for the analysis of carbaryl residues in environmental water samples. Copyright © 2004 John Wiley & Sons, Ltd.
Using information technology to improve surgical safety
Authors: Bates D W 
Published: July 2004

Abstract
Patient Safety Leading Article Series, 2004 Dr David W Bates of Harvard Medical School, and Brigham and Women's Hospital, Boston, has for some years had a major interest in information technology in healthcare. Here, he continues our ‘Patient Safety’ series of leading articles, exploring how the tools of the modern era can help avoid harm in the surgical arena.
Critical evaluation of the different staging systems for hepatocellular carcinoma (Br J Surg 2004; 91: 400-408)
Authors: Vauthey Jean-Nicolas , Pawlik Timothy M , Lauwers Gregory Y , Nagorney David M , Roh Mark S , Curley Steven A , Poon Ronnie T , Belghiti Jacques , Greene Frederick , Michael Henderson J 
Published: July 2004

Abstract
The Editors welcome topical correspondence from readers relating to articles published in the Journal. Responses can be sent electronically via the BJS website (www.bjs.co.uk) or by post. All letters will be reviewed and, if approved, appear on the website. A selection of these will be edited and published in the Journal. Letters must be no more than 250 words in length. Letters submitted by post should be typed on A4-sized paper in double spacing and should be accompanied by a disk.
Synthesis, Linear, and Quadratic‐Nonlinear Optical Properties of Octupolar D3 and D2d Bipyridyl Metal Complexes
Authors: Maury Olivier , Viau Lydie , Sénéchal Katell , Corre Brigitte , Guégan Jean‐Paul , Renouard Thierry , Ledoux Isabelle , Zyss Joseph , Le Bozec Hubert 
Published: July 2004

AbstractA series of D3 (FeII, RuII, ZnII, HgII) and D2d (CuI, AgI, ZnII) octupolar metal complexes featuring different functionalized bipyridyl ligands has been synthesized, and their thermal, linear (absorption and emission), and nonlinear optical (NLO) properties were determined. Their quadratic NLO susceptibilities were determined by harmonic light scattering at 1.91 μm, and the molecular hyperpolarizability (β0) values are in the range of 200–657×10−30 esu for octahedral complexes and 70–157×10−30 esu for tetrahedral complexes. The octahedral zinc(II) complex 1 e, which contains a 4,4′‐oligophenylenevinylene‐functionalized 2,2′‐bipyridine, exhibits the highest quadratic hyperpolarizability ever reported for an octupolar derivative (λmax=482 nm, β1.91(1 e)=870×10−30 esu, β0(1 e)=657×10−30 esu). Herein, we demonstrate that the optical and nonlinear optical (NLO) properties are strongly influenced by the symmetry of the complexes, the nature of the ligands (donor endgroups and π linkers), and the nature of the metallic centers. For example, the length of the π‐conjugated backbone, the Lewis acidity of the metal ion, and the increase of ligand‐to‐metal ratio result in a substantial enhancement of β. The contribution of the metal‐to‐ligand (MLCT) transition to the molecular hyperpolarizability is also discussed with respect to octahedral d6 complexes (M=Fe, Ru).
A Photochemical Activation Scheme of Inert Dinitrogen by Dinuclear RuII and FeII Complexes
Authors: Reiher Markus , Kirchner Barbara , Hutter Jürg , Sellmann Dieter , Hess Bernd Artur 
Published: July 2004

AbstractA general photochemical activation process of inert dinitrogen coordinated to two metal centers is presented on the basis of high‐level DFT and ab initio calculations. The central feature of this activation process is the occupation of an antibonding π* orbital upon electronic excitation from the singlet ground state S0 to the first excited singlet state S1. Populating the antibonding LUMO weakens the triple bond of dinitrogen. After a vertical excitation, the excited complex may structurally relax in the S1 state and approaches its minimum structure in the S1 state. This excited‐state minimum structure features the dinitrogen bound in a diazenoid form, which exhibits a double bond and two lone pairs localized at the two nitrogen atoms, ready to be protonated. Reduction and de‐excitation then yield the corresponding diazene complex; its generation represents the essential step in a nitrogen fixation and reduction protocol. The consecutive process of excitation, protonation, and reduction may be rearranged in any experimentally appropriate order. The protons needed for the reaction from dinitrogen to diazene can be provided by the ligand sphere of the complexes, which contains sulfur atoms acting as proton acceptors. These protonated thiolate functionalities bring protons close to the dinitrogen moiety. Because protonation does not change the π*‐antibonding character of the LUMO, the universal and well‐directed character of the photochemical activation process makes it possible to protonate the dinitrogen complex before it is irradiated. The π*‐antibonding LUMO plays the central role in the activation process, since the diazenoid structure was obtained by excitation from various occupied orbitals as well as by a direct two‐electron reduction (without photochemical activation) of the complex; that is, the important bending of N2 towards a diazenoid conformation can be achieved by populating the π*‐antibonding LUMO.
Topological Analysis of Electron Densities: Is the Presence of an Atomic Interaction Line in an Equilibrium Geometry a Sufficient Condition for the Existence of a Chemical Bond?
Authors: Haaland Arne , Shorokhov Dimitry J. , Tverdova Natalya V. 
Published: July 2004

AbstractThe structure, energetics, and electron density in the inclusion complex of He in adamantane, C10H16, have been studied by density functional theory calculations at the B3LYP6‐311++G(2p,2d) level. Topological analysis of the electron density shows that the He atom is connected to the four tertiarytC atoms in the cage by atomic interaction lines with (3,−1) critical points. The calculated dissociation energy of the complex He@adamantane(g)=adamantane(g) + He(g) of ΔE=−645 kJ mol−1nevertheless shows that the He–tC interactions areantibonding.
Stereochemical studies of chiral resolving agents, M9PP and H9PP acids
Authors: Ichikawa Akio , Ono Hiroshi , Harada Nobuyuki 
Published: July 2004

AbstractThe stereoselective Grignard reaction of (1R,2S,5R)‐(–)‐2‐isopropyl‐5‐methylcyclohexyl pyruvate (menthyl pyruvate) with 9‐phenanthrylmagnesium bromide yielded diastereomeric hydroxy‐esters, where intramolecular OH…O=C hydrogen bond was observed in IR and 1H NMR spectra. The alkaline hydrolysis of the major product gave (+)‐2‐hydroxy‐2‐(9‐phenanthryl)propionic acid (H9PP acid (3)), whose absolute configuration was assigned as S based on the chemical correlation with (1R,2S,5R)‐2‐isopropyl‐5‐methylcyclohexyl ester of (S)‐2‐methoxy‐2‐(9‐phenanthryl)propionic acid (M9PP acid (2)); the absolute configuration of 2 had been previously established by X‐ray crystallography. The enantioresolution of (±)‐6‐methyl‐5‐hepten‐2‐ol, sulcatol, an insect pheromone, was carried out using (S)‐(+)‐M9PP acid 2. Chirality 16:559–567, 2004. © 2004 Wiley‐Liss, Inc.
Prognostic value of P53, MDM‐2, and MUC‐1 for patients with inflammatory breast carcinoma
Authors: Resetkova Erika , Gonzalez‐Angulo Ana M. , Sneige Nour , Mcdonnell Timothy J. , Buzdar Aman U. , Kau Shu Wan , Yamamura Yuko , Reuben James M. , Hortobagyi Gabriel N. , Cristofanilli Massimo 
Published: July 2004

AbstractBACKGROUNDInflammatory breast carcinoma (IBC) is a rare and aggressive malignancy. Therapy for patients with IBC is multidisciplinary, and response to preoperative chemotherapy is considered an important predictor of outcome. Although only a limited number of molecular markers have been investigated in this setting, none has exhibited prognostic value for patients with IBC.METHODSImmunohistochemical assays for P53, MDM‐2, and MUC‐1 were performed retrospectively to evaluate potential correlations between these markers and pathologic response, time to progression (TTP), and overall survival (OS) in 19 patients with IBC.RESULTSAfter a median follow‐up period of 46 months, patients with tumors that overexpressed P53 and did not express MUC‐1 had a significantly shorter median TTP and median OS compared with other patients.CONCLUSIONSExpression of P53 and MUC‐1 may be predictive of treatment efficacy and outcome for patients with IBC. Furthermore, these two markers may represent novel therapeutic targets in such patients. Cancer 2004. © 2004 American Cancer Society.