bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transepistemes devinientes de las rupturas asignificantes: decolonialidad planetaria-complejidad
Authors: Rodríguez Milagros Elena 
Published: October 2023

Asumiendo que la decolonialidad planetaria es apodíctica de la complejidad y de la transdisciplinariedad, bajo rupturas asignificantes, en condiciones abiertas para conformar al ser humano a pensar complejamente, sustentamos transepistemes devinientes de las rupturas asignificantes de la decolonialidad planetaria-complejidad como objetivo complejo de indagación; en las líneas de investigación: educación-transepistemologías transcomplejas, Decolonialidad planetaria-complejidad en re-ligaje y transepistemologías de los conocimientos-saberes y transmetodologías transcomplejas. Lo realizamos con el transmétodo la hermenéutica comprensiva, ecosófica y diatópica; en los momentos analíticos, empíricos y propositivos. En el momento propositivo los transepistemes decoloniales planetarios – complejos van desmitificando des-ligando los epistemes fijos con pretendidas y vendidas aseveraciones hacia el colonizador. Los transepistemes por su esencia decolonial planetaria ponen en igual grado de importancia todos los saberes ancestrales, y desde el patrimonio histórico de las civilizaciones aportan al conocer desde transmetodologías otras, abiertas, inclusivas; transdisciplinares fuera de los impositores de la destrucción de la naturaleza en una falsa conquista; por ello salvaguardar los saberes ancestrales como transepistemes ricos en amor por la humanidad es aceptar que somos naturaleza en la Tierra como patria. Transepistemes transdisciplinares como ejercicios de liberación, conocedores y promotores de la complejidad de la vida; es una esencia característica de los transepistemes que nos incitan a una nueva civilización de hacer ciencia, de conocer rompiendo las fronteras de las ciencias.
Analisis Ketepatan Pengkodean Diagnosis Hipertensi Di Rumah Sakit Arjawinangun
Authors: Rahmawati Fitria Dewi 
Published: October 2023

Abstrak Salah satu target global penyakit tidak menular adalah menurunkan prevalensi Hipertensi sebesar 33% antara tahun 2010 dan 2030. Hipertensi merupakan salah satu standar pelayanan minimal (SPM) kesehatan di Indonesia. Angka Cakupan pelayanan kesehatan penderita hipertensi di Jawa barat tahun 2020 sebesar 34,7 % berdasarkan hasil pengukuran tekanan darah. Cakupan pelayanan kesehatan penderita hipertensi tertinggi di Jawa Barat terjadi di kota Cirebon. Pelaporan morbiditas kasus hipertensi di Rumah Sakit dibagi menjadi kode I10 dan I11-I15 pada ICD-10. Ketidakakuratan kode diagnosis akan mempengaruhi data dan informasi laporan, ketepatan tarif INA-CBG’s yang pada saat ini digunakan sebagai metode pembayaran untuk pelayanan pasien dengan asuransi atau jaminan. Dampak yang terjadi ketika terdapat ketidaktepatan dalam kode hasil verifikasi dari BPJS akan terjadi kelebihan pembayaran atau kekurangan pembayaran. Tujuan penelitian ini untuk mengetahui pelaksanaan kodifikasi pasien Hipertensi rawat jalan di Rumah Sakit Arjawinangun. Metode penelitian yang digunakan adalah deskriptif kuantitatif dengan desain penelitian analisis univariat. Pengumpulan data dengan menggunakan instrumen ceklist. Sampel penelitian sebanyak 73 pasien dari populasi kunjungan
Implementation of the Prolanis Online Health Service Management Information System Application (SIMPELPRO) at the Semarang City Public Health Center , Case Study at Padangsari Public Health Center Semarang City
Authors: Wijayanta Setya - , Masrochah Siti , Subinarto Subinarto , Naryanti Indah 
Published: October 2023

The government is working to reduce the prevalence of chronic diseases and prevent people with chronic diseases from entering the complication stage. One form of effort in this regard is through the chronic disease management program (Prolanis). So that the participants do not know the types of activities and schedules of Prolanis activities so that participants do not take advantage of them. The purpose of this study was to examine the implementation of the online prolanis service management information system application (SIMPELPRO) at the Semarang City Public Health Center, a case study at the Padangsari Public Health Center. This research method is descriptive, with primary data sources from interviews, documentation studies and literature. System design using the prototype method. Prototypes were made and evaluated, and continued to the implementation stage. The result of this study Has been developed using SIMPELPRO web based application for service management of Prolanis activities. The focus of the application in this research is still on the presentation of the health education materials. The development uses the prototype method with UML as a design tool. The application has received positives feedbacks from Prolanis participants, Although some participants have complainedabout limited access to smartphones and the need for assistance for elderly participants.
Ethnomedicinal application, phytochemistry and therapeutic effects of genus clerodendrum
Authors: Ogunlakin Akingbolabo Daniel , Akinwumi Idayat Adeola , Ambali Owoola Azeezat 
Published: October 2023

The genus Clerodendrum consist of flowering plants, which was once classified as a member of the Verbenaceae family, was recently classified as a member of the Lamiaceae family. Various species of this genus have been generally used for treating several ailments and disorders as well as ornamental plants. Secondary metabolites found in abundance in these species include terpenoids, saponins, carbohydrates, and glucosides as well as alkaloids, flavonoids, and phenolic compounds. Studies conducted so far have shown that the extracts and compounds of the species in this genus exert diverse physiological activities, including anti-inflammatory, anti-diabetic, antihypertensive, anti-allergic, analgesic, hepatoprotective, post-coital antifertility, antimicrobial, anticholinesterase, membrane stabilizing, antihelmitic, hypolipidemic, antitumor, and antimicrobial properties. Medicinal plants in this genus are beneficial, therefore they should be considered as lead in drug discovery and formulation.Keywords: Clerodendrum species, Forkloric uses, Pharmacological application, Phytoconstituents, Therapeutics
Modelling a machine learning based multivariate content grading system for YouTube Tamil-post analysis
Authors: Srivatsun G. , Thivaharan S. 
Published: October 2023

Writing is a crucial component of the language requirement and is an effective method for correctly reflecting language proficiency. Manually evaluating Tamil language exams becomes time-consuming and costly for standardized language administrators as they grow in popularity. Numerous studies on computerized English assessment systems have been conducted in recent years. Due to Tamil text’s complicated grammatical structures, less research has been done on computerized evaluation methods. In this research, we present a Tamil review comment analysis system using a novel multivariate naïve Bayes classifier (mv - NB) where the comments are acquired from an online social network and performed training using the database for further analysis. Experiments show that the graded Kappa of 0.4239, error rate of 2.55 and precision of 85% was achieved on the online dataset by our contents grading system, which is superior in grading compared to the other widely used machine learning algorithms training on big datasets. Our findings are promising. Additionally, our contents analysis may provide beneficial criticism on Tamil writing on YouTube posts including comments, spelling errors and morphological issues that help to analyze thelanguage correlation.
Impaired Neurodevelopment in Children with 5q-SMA - 2 Years After Newborn Screening
Authors: Kölbel Heike , Kopka Marius , Modler Laura , Blaschek Astrid , Schara-Schmidt Ulrike , Vill Katharina , Schwartz Oliver , Müller-Felber Wolfgang 
Published: October 2023

Objective: Numerous studies have consistently found that reduced SMN protein expression does not severely affect cognitive function in SMA patients. However, the average intelligence quotient of SMA patients has ranged above to below average in different studies. The cognitive development of SMA patients identified through newborn screening remains largely unknown. Methods: 40 of 47 eligible SMA patients (23 females/17 males) from 39 families identified through newborn screening between January 2018 and December 2020 underwent developmental testing using Bayley III (BSID) after the 2 years of age. The mean age was 29.25 months (23–42 months). 17 patients had 2, 11 patients had 3 and 12 patients had ≥4 copies of SMN2. Results: cognitive scale: mean 94.55 (SD 24.01); language scale: mean 86.09 (SD 26.41); motor scale: 81.28 (SD 28.07). Overall, the cognitive scales show that 14 children were below average, 20 children were average and 6 children were above average. 10/14 children with below average scores had 2 SMN2 copies. The post-hoc pairwise comparisons showed that the cognition main scale was significantly more sensitive to the number of SMN2 copies than the motor main scale of the BSID (M Δ= 10.27, p = 0.014). There is also evidence that cognition scored higher than the language main scale (M Δ= 7.11, p = 0.090). Conclusion: The impaired cognitive development of SMA children with 2 SMN2 copies, despite early initiation of therapy, underscores the critical role of the SMN protein in the early stages of brain development.
Reform of Labor Wage Determination Provisions: Review of Welfare and Importance in the Job Creation Law
Authors: Chelsea Mutiara Putri  , Hutapea Annisa Khairiyah , Ramadhani Zaky Ihsan Edy 
Published: October 2023

The passing of the Job Creation Law by the government is considered to show more partiality to investors or entrepreneurs and marginalizes labor rights, especially in terms of wages, Indonesia's goal to create and guarantee community welfare in accordance with the concept of the Welfare State (Welfare State) adopted becomes blurred. This article focuses on the discussion related to the first the determination of the minimum wage submitted to the authority of the Governor and by referring to the economic growth of the Regions and inflation conditions of each Region. Second, the Decent Living Needs (KHL) is no longer an indicator of determining the minimum wage for workers. Third, the abolition of sectoral minimum wages previously in the Manpower Law. This article uses the Juridical-Normative research method. This article found that the Economic growth and inflation rate of each region / province vary. Thus the Minimum Wage cannot be equated between people in each region. In an effort to realize equality of position for employers, Law No. 6 of 2023 has denied the state's obligation to protect workers' rights, thus clashing with Article 27 paragraph (2) of the 1945 Constitution. The policy of abolishing the sectoral minimum wage in the Job Creation Law will cause inequality between sectors and cause a sense of injustice for workers.
EVALUASI KINERJA PELABUHAN NAMBO WILKER LAWELE SEBAGAI SIMPUL UTAMA DISTRIBUSI ASPAL BUTON
Authors: Aldinoman Aldinoman , Kadir Abdul , Putra Adris Adi 
Published: October 2023

Penelitian ini bertujuan mengevaluasi kinerja Eksisiting Pelabuhan nambo/lawele dan menyusun strategi pengembangan Pelabuhan Nambo sebagai simpul utama pendistribusian aspal buton. Metode penelitian dilakukan dengan mengevaluasi data kondisi ekisting Pelabuhan (kondisi topografi, kondisi hidrometri, hidroecanografi), kemudian melakukan analisis kinerja Pelayanan Pelabuhan sesuai dengan Keputusan Dirjen Perhubungan Laut Nomor : UM.002/38/18/DJPL-11 tanggal 15 Desember 2011 dan Peraturan Dirjen Hubla No. HK103/2/2/DJPL/-17 tentang Pedoman Perhitungan Kinerja Pelayanan Operasional Pelabuhan yang match dengan data produktivitas selama 5 (lima) tahun terakhir dan proyeksi produktivitas 20 tahun kedepan. Kemudian perumusan strategi dilakukan dengan analisis SWOT. Dari hasil penelitian diperoleh kinerja eksisting pelayanan Pelabuhan Nambo dengan indikator waktu pelayanan tambat, pelayanan bongkat-muat di dermaga, dan utilisasi fasilitas Pelabuhan dalam kategori baik dan memenuhi standar kinerja yang ditetapkan oleh Kementerian Perhubungan. Namun dari hasil proyeksi produktivitas 20 (dua puluh) tahun ke depan, kinerja fasilitas eksisting dalam kategori kurang baik. Dari hasil analisis SWOT diperoleh Pelabuhan nambo berada di kuadran I berarti pelabuhan mempunyai peluang dan kekuatan dan strategi pengembangan yang dilakukan adalah mendukung kebijakan pertumbuhan yang agresif atau growth oriented strategy dengan memanfaatkan peluang yang ada serta kekuatan internal yang dimiliki mencoba meminimalisir kelemahan, menggunakan tingkat kekuatan sebagai modal utama, serta menekan kelemahan yang akan berpotensi akan mengurangi kekuatan dan menghilangkan ancaman yang ada.
Kata Kunci : Pelabuhan, Kinerja, Strategi
Biomimetic electrospun nanofibrous scaffold for tissue engineering: preparation, optimization by design of experiments (DOE), in-vitro and in-vivo characterization
Authors: Anjum Shabnam , Li Ting , Arya Dilip Kumar , Ali Daoud , Alarifi Saud , Yulin Wang , Hengtong Zhang , Rajinikanth P. S. , Ao Qiang 
Published: October 2023

Electrospinning is a versatile method for fabrication of précised nanofibrous materials for various biomedical application including tissue engineering and drug delivery. This research is aimed to fabricate the PVP/PVA nanofiber scaffold by novel electrospinning technique and to investigate the impact of process parameters (flow rate, voltage and distance) and polymer concentration/solvent combinations influence on properties of electrospun nanofibers. The in-vitro and in-vivo degradation studies were performed to evaluate the potential of electrospun PVP/PVA as a tissue engineering scaffold. The solvents used for electrospinning of PVP/PVA nanofibers were ethanol and 90% acetic acid, optimized with central composite design via Design Expert software. NF-2 and NF-35 were selected as optimised nanofiber formulation in acetic acid and ethanol, and their characterization showed diameter of 150–400 nm, tensile strength of 18.3 and 13.1 MPa, respectively. XRD data revealed the amorphous nature, and exhibited hydrophilicity (contact angles: 67.89° and 58.31° for NF-2 and NF-35). Swelling and in-vitro degradability studies displayed extended water retention as well as delayed degradation. FTIR analysis confirmed solvent-independent interactions. Additionally, hemolysis and in-vitro cytotoxicity studies revealed the non-toxic nature of fabricated scaffolds on RBCs and L929 fibroblast cells. Subcutaneous rat implantation assessed tissue response, month-long biodegradation, and biocompatibility through histological analysis of surrounding tissue. Due to its excellent biocompatibility, this porous PVP/PVA nanofiber has great potential for biomedical applications.
A case report of left ventricular lead implantation via total three-dimensional transseptal puncture after tricuspid valve replacement
Authors: Gao Jia , Zhang Nan , Zhang Binghang , Sun Meng , Meng Zhijun , Guo Min , Wang Rui 
Published: October 2023

BackgroundVentricular lead implantation is relatively difficult for patients with bradyarrhythmia after tricuspid valve replacement. Right atrial (RA) abnormalities often occurred in patients with tricuspid valve disease; conventional coronary sinus (CS) lead implantation is not easy to operate. Therefore, it is necessary to develop a safe method for implanting LV endocardial leads in patients after tricuspid valve replacement.Case presentationA 76-year-old Asian woman who had been implanted with a metal tricuspid valve replacement 4 years ago was admitted to the Department of Cardiology for pacemaker implantation due to transient blackout related to persistent atrial fibrillation with long pauses. The patient's family rejected the surgical placement of an epicardial LV lead. Therefore, we first intended to operate LV lead implantation through the CS; however, the orifice of the CS was virtually difficult to seek. Ultimately, we utilized total 3-dimensional (T3D) transseptal puncture (TSP) under the guidance of the CARTO 3 system; thus, we implanted the LV endocardial lead, which contributed to the accurate puncture of the central fossa ovalis and ensured the safety of TSP in the case of RA enlargement. Meanwhile, the CARTO 3 system contributed to the localization of the LV lead to the LV free wall during implantation. All the intraoperative and postoperative pacemaker parameters were favorable; no intraoperative or postoperative complications occurred.ConclusionsThis case report may provide a novel surgical approach for LV lead implantation in patients who underwent tricuspid valve replacement or patients who may benefit from cardiac resynchronization therapy but failed to implant CS lead.
A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses
Authors: Smith Katherine E. R. , Peng Kah-Whye , Pulido Jose S. , Weisbrod Adam J. , Strand Carrie A. , Allred Jacob B. , Newsom Alysha N. , Zhang Lianwen , Packiriswamy Nandakumar , Kottke Timothy , Tonne Jason M. , Moore Madelyn , Montane Heather N. , Kottschade Lisa A. , McWilliams Robert R. , Dudek Arkadiusz Z. , Yan Yiyi , Dimou Anastasios , Markovic Svetomir N. , Federspiel Mark J. , Vile Richard G. , Dronca Roxana S. , Block Matthew S. 
Published: October 2023

IntroductionMetastatic uveal melanoma (MUM) has a poor prognosis and treatment options are limited. These patients do not typically experience durable responses to immune checkpoint inhibitors (ICIs). Oncolytic viruses (OV) represent a novel approach to immunotherapy for patients with MUM.MethodsWe developed an OV with a Vesicular Stomatitis Virus (VSV) vector modified to express interferon-beta (IFN-β) and Tyrosinase Related Protein 1 (TYRP1) (VSV-IFNβ-TYRP1), and conducted a Phase 1 clinical trial with a 3 + 3 design in patients with MUM. VSV-IFNβ-TYRP1 was injected into a liver metastasis, then administered on the same day as a single intravenous (IV) infusion. The primary objective was safety. Efficacy was a secondary objective.Results12 patients with previously treated MUM were enrolled. Median follow up was 19.1 months. 4 dose levels (DLs) were evaluated. One patient at DL4 experienced dose limiting toxicities (DLTs), including decreased platelet count (grade 3), increased aspartate aminotransferase (AST), and cytokine release syndrome (CRS). 4 patients had stable disease (SD) and 8 patients had progressive disease (PD). Interferon gamma (IFNγ) ELIspot data showed that more patients developed a T cell response to virus encoded TYRP1 at higher DLs, and a subset of patients also had a response to other melanoma antigens, including gp100, suggesting epitope spreading. 3 of the patients who responded to additional melanoma antigens were next treated with ICIs, and 2 of these patients experienced durable responses.DiscussionOur study found that VSV-IFNβ -TYRP1 can be safely administered via intratumoral (IT) and IV routes in a previously treated population of patients with MUM. Although there were no clear objective radiographic responses to VSV-IFNβ-TYRP1, dose-dependent immunogenicity to TYRP1 and other melanoma antigens was seen.
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia
Authors: Li Zhongzheng , Liu Xin , Wang Lan , Zhao Huabin , Wang Shenghui , Yu Guoying , Wu Depei , Chu Jianhong , Han Jingjing 
Published: October 2023

IntroductionAcute myeloid leukemia (AML) is a type of blood cancer that is identified by the unrestricted growth of immature myeloid cells within the bone marrow. Despite therapeutic advances, AML prognosis remains highly variable, and there is a lack of biomarkers for customizing treatment. RNA N6-methyladenosine (m6A) modification is a reversible and dynamic process that plays a critical role in cancer progression and drug resistance.MethodsTo investigate the m6A modification patterns in AML and their potential clinical significance, we used the AUCell method to describe the m6A modification activity of cells in AML patients based on 23 m6A modification enzymes and further integrated with bulk RNA-seq data.ResultsWe found that m6A modification was more effective in leukemic cells than in immune cells and induced significant changes in gene expression in leukemic cells rather than immune cells. Furthermore, network analysis revealed a correlation between transcription factor activation and the m6A modification status in leukemia cells, while active m6A-modified immune cells exhibited a higher interaction density in their gene regulatory networks. Hierarchical clustering based on m6A-related genes identified three distinct AML subtypes. The immune dysregulation subtype, characterized by RUNX1 mutation and KMT2A copy number variation, was associated with a worse prognosis and exhibited a specific gene expression pattern with high expression level of IGF2BP3 and FMR1, and low expression level of ELAVL1 and YTHDF2. Notably, patients with the immune dysregulation subtype were sensitive to immunotherapy and chemotherapy.DiscussionCollectively, our findings suggest that m6A modification could be a potential therapeutic target for AML, and the identified subtypes could guide personalized therapy.
Real-world post-deployment performance of a novel machine learning-based digital health technology for skin lesion assessment and suggestions for post-market surveillance
Authors: Thomas Lucy , Hyde Chris , Mullarkey Dan , Greenhalgh Jack , Kalsi Dilraj , Ko Justin 
Published: October 2023

IntroductionDeep Ensemble for Recognition of Malignancy (DERM) is an artificial intelligence as a medical device (AIaMD) tool for skin lesion assessment.MethodsWe report prospective real-world performance from its deployment within skin cancer pathways at two National Health Service hospitals (UK) between July 2021 and October 2022.ResultsA total of 14,500 cases were seen, including patients 18–100 years old with Fitzpatrick skin types I–VI represented. Based on 8,571 lesions assessed by DERM with confirmed outcomes, versions A and B demonstrated very high sensitivity for detecting melanoma (95.0–100.0%) or malignancy (96.0–100.0%). Benign lesion specificity was 40.7–49.4% (DERM-vA) and 70.1–73.4% (DERM-vB). DERM identified 15.0–31.0% of cases as eligible for discharge.DiscussionWe show DERM performance in-line with sensitivity targets and pre-marketing authorisation research, and it reduced the caseload for hospital specialists in two pathways. Based on our experience we offer suggestions on key elements of post-market surveillance for AIaMDs.