bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the predictive value of neutrophil percentage to albumin ratio for ICU admission in ischemic stroke patients
Authors: Zawiah Mohammed , Khan Amer Hayat , Farha Rana Abu , Usman Abubakar , Al-Ashwal Fahmi Y. , Akkaif Mohammed Ahmed 
Published: February 2024

BackgroundAcute ischemic stroke (AIS) remains a substantial global health challenge, contributing to increased morbidity, disability, and mortality. This study aimed at investigating the predictive value of the neutrophil percentage to albumin ratio (NPAR) in determining intensive care unit (ICU) admission among AIS patients.MethodsA retrospective observational study was conducted, involving AIS cases admitted to a tertiary hospital in Jordan between 2015 and 2020. Lab data were collected upon admission, and the primary outcome was ICU admission during hospitalization. Descriptive and inferential analyses were performed using SPSS version 29.ResultsIn this study involving 364 AIS patients, a subset of 77 (21.2%) required admission to the ICU during their hospital stay, most frequently within the first week of admission. Univariable analysis revealed significantly higher NPAR levels in ICU-admitted ischemic stroke patients compared to those who were not admitted (23.3 vs. 15.7, p &lt; 0.001), and multivariable regression models confirmed that higher NPAR (≥19.107) independently predicted ICU admission in ischemic stroke patients (adjusted odds ratio [aOR] = 4.85, 95% CI: 1.83–12.83). Additionally, lower GCS scores and higher neutrophil-to-lymphocyte ratio (NLR) were also associated with increased likelihood of ICU admission. In terms of predictive performance, NPAR showed the highest accuracy with an AUC of 0.885, sensitivity of 0.805, and specificity of 0.854, using a cutoff value of 19.107. NPAR exhibits an AUC of 0.058, significantly outperforming NLR (Z = 2.782, p = 0.005).ConclusionNPAR emerged as a robust independent predictor of ICU admission in ischemic stroke patients, surpassing the predictive performance of the NLR.
Cognitive outcomes in patients with essential tremor treated with deep brain stimulation: a systematic review
Authors: Al Ali Jamal , Lacy Maureen , Padmanaban Mahesh , Abou Chaar Widad , Hagy Hannah , Warnke Peter C. , Xie Tao 
Published: February 2024

IntroductionEssential tremor (ET) is a common neurological disease. Deep brain stimulation (DBS) to the thalamic ventral intermediate nucleus (VIM) or the adjacent structures, such as caudal zona incerta/ posterior subthalamic area (cZi/PSA), can be effective in treating medication refractory tremor. However, it is not clear whether DBS can cause cognitive changes, in which domain, and to what extent if so.MethodsWe systematically searched PubMed and the Web of Science for available publications reporting on cognitive outcomes in patients with ET who underwent DBS following the PICO (population, intervention, comparators, and outcomes) concept. The PRISMA guideline for systematic reviews was applied.ResultsTwenty relevant articles were finally identified and included for review, thirteen of which were prospective (one also randomized) studies and seven were retrospective. Cognitive outcomes included attention, memory, executive function, language, visuospatial function, and mood-related variables. VIM and cZi/PSA DBS were generally well tolerated, although verbal fluency and language production were affected in some patients. Additionally, left-sided VIM DBS was associated with negative effects on verbal abstraction, word recall, and verbal memory performance in some patients.ConclusionSignificant cognitive decline after VIM or cZi/PSA DBS in ET patients appears to be rare. Future prospective randomized controlled trials are needed to meticulously study the effect of the location, laterality, and stimulation parameters of the active contacts on cognitive outcomes while considering possible medication change post-DBS, timing, standard neuropsychological battery, practice effects, the timing of assessment, and effect size as potential confounders.
Advancing breastfeeding promotion: leveraging integrative natural galactagogues and unveiling their potential roles—Insights from a 19-year Taiwan nationwide registry to address lactation insufficiency in postpartum women
Authors: Liao Chung-Chih , Chien Chi-Hsien , Hsu Tzu-Ju , Li Jung-Miao 
Published: February 2024

BackgroundLactation insufficiency is a prevalent challenge for nursing mothers globally. There is a growing interest in the use of herbal galactagogues for enhancing lactation, but their therapeutic efficacy and underlying mechanisms need thorough investigation. This study aims to investigate the efficacy and mechanisms of action of herbal galactagogues in addressing lactation insufficiency by utilizing real-world data and employing a network analysis approach.MethodsOur retrospective study used Taiwan’s Longitudinal Health Insurance Database 2000 (LHID2000) to identify 490 patients diagnosed with lactation insufficiency from 2000 to 2018. We analyzed demographic characteristics, co-existing diseases, and prescription patterns for both users and non-users of Chinese herbal products (CHP). Additionally, we utilized a network analysis approach to explore potential compounds and targets in the most frequently used CHP, the Wang Bu Liu Xing and Lu Lu Tong herb pair (WLHP) combination.ResultsOut of 490 patients, 81% were CHP users. There were no significant differences in demographic characteristics between CHP users and non-users, but we observed a notable divergence in the prevalence of co-existing diseases. A detailed examination of CHP prescriptions revealed the predominance of WLHP, prompting further investigation. Comprehensive analysis identified 29 major compounds in WLHP, which were associated with 215 unique targets. Intersection analysis revealed 101 overlapping targets between WLHP and lactation, suggesting their potential as therapeutic targets for lactation insufficiency treatment. Topological analysis of the protein-protein interaction (PPI) network identified 13 hub genes potentially crucial for the therapeutic effect of WLHP. Functional enrichment analysis showed that these targets were involved in critical lactation regulation pathways, including the PI3K-Akt signaling pathway, prolactin signaling pathway, estrogen signaling pathway, and AMPK signaling pathway.DiscussionThis study emphasizes the potential of CHP, specifically the WLHP combination, in managing lactation insufficiency. The multi-compound, multi-target approach of WLHP and its interaction with key biological processes and signaling pathways offer valuable insights into the underlying mechanisms of its therapeutic effects. These findings warrant further experimental validation and can guide future research and clinical applications of CHP in lactation insufficiency treatment.
Non-ionizing measurement and quantification of bell-shaped chests in spinal muscular atrophy: a pilot study
Authors: Amirav Israel , Rabin Neta , Levi Sapir , Har-Even Cohn Ronly , Lior Yotam , Shiran Shelly , Sagi Liora , Fatal Aviva , Zvirin Alon , Honen Yaron , Lavie Moran , Kimmel Ron 
Published: February 2024

BackgroundSpinal Muscular Atrophy (SMA) is manifested by deformation of the chest wall, including a bell-shaped chest. We determined the ability of a novel non-ionizing, non-volitional method to measure and quantify bell-shaped chests in SMA.MethodsA 3D depth camera and a chest x-ray (CXR) were used to capture chest images in 14 SMA patients and 28 controls. Both methods measure the distance between two points, but measurements performed by 3D analysis allow for the consideration of the curve of a surface (geodesic measurements), whereas the CXR allows solely for the determination of the shortest path between two points, with no regard for the surface (Euclidean measurements). The ratio of the upper to lower chest distances was quantified to distinguish chest shape in imaging by both the 3D depth camera and the CXR, and the ratios were compared between healthy and SMA patients.ResultsThe mean 3D Euclidean ratio of distances measured by 3D imaging was 1.00 in the control group and 0.92 in the SMA group (p = 0.01), the latter indicative of a bell-shaped chest. This result repeated itself in the ratio of geodesic measurements (0.99 vs. 0.89, respectively, p = 0.03).ConclusionThe herein-described novel, noninvasive 3D method for measuring the upper and lower chest distances was shown to distinguish the bell-shaped chest configuration in patients with SMA from the chests of controls. This method bears several advantages over CXR and may be readily applicable in clinical settings that manage children with SMA.
Adult Attachment Questionnaire: evidence of validity in a sample of IPVAW offenders
Authors: Osa-Subtil Iria de la , Arias Astray Andrés , Mateo Fernandez Pedro Vicente , de Dios-Duarte María José 
Published: February 2024

IntroductionAdult attachment can be understood as a cognitive and emotional system concerning oneself and others, based on previous attachment experiences throughout life. This system automatically affects relationships with others. Because of its importance in the interpersonal domain, it has been studied on numerous occasions in research on intimate partner violence. The aim of this study was to obtain evidence of validity of the Adult Attachment Questionnaire (AAQ) in a sample of 331 men convicted of intimate partner violence against women (IPVAW).MethodsThe AAQ assesses adult attachment style in four dimensions that, together, yield four attachment categories. A psychometric analysis was performed, including reliability analysis and confirmatory factor analysis of the items, which ratified the factorial structure of the questionnaire. For a correct fit of the model, it was necessary to eliminate 4 of the items from the original scale.ResultsA latent profile analysis was also carried out, which identified four attachment styles: secure, preoccupied/anxious, avoidant/dismissing and fearful. Reliability indices were adequate. In general, the attachment profiles obtained ranges and means similar to those found in the general population study. The distribution of attachment styles was not equal: 50.57% of the participants presented secure attachment, 4.57% avoidant/dismissing attachment, 36.9% preoccupied/anxious, and 8.57% fearful.DiscussionIn conclusion, a valid and reliable instrument was determined based on the original AAQ scale to measure attachment in men convicted of IPVAW.
Exploring discontinuous intentions of social media users: a cognition-affect-conation perspective
Authors: Qaisar Sara , Nawaz Kiani Anum , Jalil Afsheen 
Published: February 2024

IntroductionDrawing on the cognition-affect-conation (C-A-C) framework, this study investigates how perceived information and social and system feature overload induce depression and anxiety, which leads to affect discontinuous intentions of the social media users.MethodsThe data collected from 570 social networking site users in China are analyzed through structural equation modeling (SEM).Results and DiscussionThe findings show that perceived information overload, perceived social overload, and perceived system feature overload directly affect depression and anxiety among social networking site users, which directly leads to discontinuous intentions. This study fulfills the identified need for an in-depth investigation of discontinuous behavior in social networking sites. The findings provide social networking site providers with guidelines on how to actively manage social networking site user’s behavior to reduce the effects of negative emotions on social networking sites.
A change in social participation affects cognitive function in middle-aged and older Chinese adults: analysis of a Chinese longitudinal study on aging (2011–2018)
Authors: Li Xuyang , Xu Wenyan 
Published: February 2024

BackgroundOne of the biggest challenges facing older adults is cognitive decline and social participation has always been considered a protective factor. However, it is not clear whether social participation predicts cognitive function in this population, rather than depressive symptoms, self-reported health, and activities of daily life, with sufficient capacity to detect unique effects.MethodsThis study included adults aged 45 and above in China (N = 5,258) who participated in a large national older adult health survey and provided data from 2011, 2013, 2015, and 2018. The unique associations between the predictors of social participation and cognitive function over time and context were evaluated in the Latent Growth Model (LGM).ResultsAmong the 5,258 participants in our study, an overall cognitive decline was observed. Social participation predicts two dimensions of cognitive function, with a degree of impact comparable to depressive symptoms, self-reported health, and activities of daily life. Among them, social participation exhibits a noteworthy prognostic impact on episodic memory during the same period. The regression coefficient is approximately 0.1 (p &lt; 0.05) after controlling other mixed variables (depressive symptoms, self-reported health, and activities of daily life). In contrast, social participation is also a significant predictor of mental intactness in the same period, with a regression coefficient of 0.06 (p &lt; 0.05), even if all mixed variables are controlled.ConclusionOver time, the correlation strength of social participation is comparable to other recognized cognitive function prediction indicators, indicating that promoting social participation among middle-aged and older Chinese adults is a meaningful way to improve cognitive function degradation, which has important policy and practical significance.
Multi-Centre UK Analysis of Simultaneous Pancreas and Kidney (SPK) Transplant in Recipients With Type 2 Diabetes Mellitus
Authors: Owen Ruth V. , Carr Harry J. , Counter Claire , Tingle Samuel J. , Thompson Emily R. , Manas Derek M. , Shaw James A. , Wilson Colin H. , White Steve A. 
Published: February 2024

90% of the UK diabetic population are classified as T2DM. This study aims to compare outcomes after SPK transplant between recipients with T1DM or T2DM. Data on all UK SPK transplants from 2003–2019 were obtained from the NHSBT Registry (n = 2,236). Current SPK transplant selection criteria for T2DM requires insulin treatment and recipient BMI &lt; 30 kg/m2. After exclusions (re-transplants/ambiguous type of diabetes) we had a cohort of n = 2,154. Graft (GS) and patient (PS) survival analyses were conducted using Kaplan-Meier plots and Cox-regression models. Complications were compared using chi-squared analyses. 95.6% of SPK transplants were performed in recipients with T1DM (n = 2,060). Univariate analysis showed comparable outcomes for pancreas GS at 1 year (p = 0.120), 3 years (p = 0.237), and 10 years (p = 0.196) and kidney GS at 1 year (p = 0.438), 3 years (p = 0.548), and 10 years (p = 0.947). PS was comparable at 1 year (p = 0.886) and 3 years (p = 0.237) and at 10 years (p = 0.161). Multi-variate analysis showed comparable outcomes in pancreas GS (p = 0.564, HR 1.221, 95% CI 0.619, 2.406) and PS(p = 0.556, HR 1.280, 95% CI 0.563, 2.911). Comparable rates of common complications were demonstrated. This is the largest series outside of the US evaluating outcomes after SPK transplants and shows similar outcomes between T1DM and T2DM recipients. It is hoped dissemination of this data will lead to increased referral rates and assessment of T2DM patients who could benefit from SPK transplantation.
Tubarões são ameaça ou ameaçados? Uma análise de percepção da comunidade acadêmica do IFPR - campus Paranaguá
Authors: Rodrigues Gabrielly Ramos , Possatto Fernanda Eria 
Published: February 2024

O presente trabalho tem como objetivo analisar a percepção dos estudantes e servidores do IFPR, Campus Paranaguá, em relação ao consumo da carne de tubarão e ao medo associado a esse grupo. A pesquisa foi realizada por meio de um questionário aplicado online e presencial. Ao finalizar o questionário, o respondente recebeu um fôlder informativo a respeito da conservação dos tubarões. Um total de 273 pessoas responderam o questionário (80 servidores, 193 alunos). Levando em consideração que os entrevistados são alunos de ensino médio e superior, assim como servidores, os respondentes demonstraram baixo conhecimento acerca da biologia dessas espécies. Um elevado número de respostas erradas foi dado em relação a: taxonomia, diferença entre tubarão x cação e a prática finning. Sugere-se a elaboração de programas e projetos de Educação Ambiental para informar jovens e adultos sobre os aspectos bioecológicos e conservação dos tubarões.
Sintetização de esmalte combinado ao óleo de melaleuca contra a onicomicose causada pela Candida albicans
Authors: Dos Santos Izadora Negreiros , Panontin Juliane Farinelli , De Castro Isis Prado Meirelles , Lopes Vinícius Gonçalves , Sesti Luís Fernando Castagnino , Cintra Marcos , Bastos Ernane Gerre Pereira 
Published: February 2024

A onicomicose é uma doença que acomete tanto as unhas dos pés como as das mãos, podendo existir diversos tipos de fungos como causa da infecção. O óleo de melaleuca, óleo essencial popular pelas suas inúmeras propriedades, é muito utilizado em diversos fármacos devido a sua alta ação antifúngica. Esse estudo objetivou avaliar uma formulação eficiente, com a menor concentração de óleo possível, diluído em esmalte básico. Para isso, foram realizados testes utilizando o fungo Candida albicans, em diferentes concentrações do óleo de melaleuca. Após a realização dos estudos preliminares, constatou-se que somente o óleo de melaleuca a 1%, 1,5%, 2% e 2,5%, 10% e 20% não é capaz de combater o fungo, mas que acima de 30% notase um início de inibição. São necessários mais testes para comprovar o potencial isolado do óleo de melaleuca.
Leucemia-Linfoma de células T do adulto associada à infecção pelo vírus linfotrópico de células T Humanas do Tipo I (HTLV-1): uma revisão abrangente
Authors: Arêdes Franciele Maria Pires , Gonçalves Geovane Henrique , Pires Alencar Arêdes , Parmagnani Isabela Carneiro , Parmagnani Lucas Carneiro 
Published: February 2024

A Leucemia-Linfoma de Células T do Adulto (ATL) é uma condição hematológica rara e agressiva, frequentemente associada à infecção pelo Vírus Linfotrópico de Células T Humanas do Tipo I (HTLV-1). Esse vírus é endêmico em várias regiões do mundo. No Brasil, encontra-se presente em todos os estados, com prevalências variadas, sendo estimado cerca de 2,5 milhões de infectados¹. A interação entre o HTLV-1 e as células do sistema imunológico desencadeia alterações genéticas e imunológicas, resultando na transformação maligna das células T e no desenvolvimento da ATLL². Classifica-se em quatro formas clínicas distintas: indolente, crônica, linfomatosa e aguda. Embora a maioria das pessoas infectadas pelo HTLV-1 não desenvolva sintomas, uma pequena proporção pode desenvolver complicações graves, incluindo leucemia/linfoma de células T do adulto³. Esta revisão atualiza conhecimentos epidemiológicos, fisiopatológicos, terapêuticos e principalmente diagnósticos do HTLV. O objetivo é permitir a suspeita etiológica do HTLV em suas diversas manifestações clínicas.
Abordagens clínicas da doença do refluxo gastroesofágico no âmbito atual: uma revisão de literatura
Authors: Araujo Aline Oliveira , Dantas Rafaella Carvalho , De Angelo Maria Gabriela Almada Lima , Do Vale Maria Fernanda Almeida , Nogueira Maria Eduarda Rossigalli Castrechini , De Sousa Gabriela Cadengue , Lima Lucyneide Rocha , Silva Danilo dos Santos , Souza Beatris Manfredini , Everton Raphaela Abreu , Álvares Rachel Fernandes , Santos Giulliana Melo Carneiro de Freitas , Da Silveira Ana Isa Queiroz , Quixaba Deborah Oliveira da Silva , Oliveira Paulo André Melo 
Published: February 2024

A Doença do Refluxo Gastroesofágico (DRGE) pode ser definida como uma condição na qual o retorno do conteúdo gástrico para o esôfago desencadeia sintomas incômodos e/ou complicações (BARREIRO,B.A e et al., 2023). Ademais, a DRGE é uma das afecções digestivas mais incidentes, cerca de 20% dos adultos nos países ocidentais e aproximadamente 5% dos asiáticos são portadores da doença e a prevalência anual dos sintomas vem aumentando por volta de 4% (BARREIRO, B.A et al., 2023). Logo, este artigo tem como objetivo analisar as abordagens clinicas da doenca do refluxo gastroesofágico no âmbito atual. Dessa forma, este estudo configura-se como uma revisão integrativa realizada por meio do levantamento bibliográfico nos diretórios: Google Scholare Scientific Eletronic LibraryOn-line (SciELO). Desta busca, foram selecionados artigos entre os anos 2021 e 2023, posteriormente submetidos aos critérios de seleção. A doença do refluxo gastroesofágico está associada a uma probabilidade 5 a 7 vezes maior de desenvolver adenocarcinoma esofágico e 60% dos pacientes com câncer relatam história de DRGE. O esôfago de Barrett é uma adaptação metaplásica das células esofágicas em que a mucosa do tipo intestinal substitui a mucosa escamosa normal. Cerca de 15% dos pacientes com DRGE desenvolvem esôfago de Barret. Contínuo a isso, os tratamento mais comuns utilizados na pratica clinica são medidas não farmacológicas como dieta, sono e fitoterapia e farmacológicas como inibidores da bomba de prótons (IBPS), bloqueadores de H2 e procinéticos. Dessa forma, conclui-se que, embora a supressão ácida seja bem-sucedida no tratamento da DRGE, não parece haver uma relação clara entre a gravidade da DRGE e os níveis elevados de ácido gástrico. Ademais, a junção do tratamento farmacológico com o não farmacológico se mostrou superior a abordagem destes de forma isolada.
A relação da vitamina D com a asma brônquica
Authors: Martins Carmen Livia Faria da Silva , Ferreira Ingridy Maria Oliveira , Haick Júlia de Miranda , Gonçalves Aline Belle Moraes , Accioly Mariana Abreu , Bezerra Heline de Mendonça , Magno Ana Paula Hesketh Campos , Castro Melina Fernandes 
Published: February 2024

Objetivo: Determinar a relação da vitamina D com a asma brônquica. Métodos: Estudo de caráter descritivo, o qual foi usado a base PubMed e a LILACS para a realização da pesquisa. Resultados: A suplementação da vitamina D teve repercussões diante da quantidade de interleucinas, o que influenciou a diminuição da exacerbação dessa patologia. Conclusão: A vitamina D está relacionada com a diminuição da exacerbação da asma, mas ainda há controvérsias acerca do assunto.
Lógica capitalista na residência multiprofissional: um desafio à ética do cuidado
Authors: Pina Melissa Martins , Araújo Samara Brito , Dos Santos Natália Macário 
Published: February 2024

Este artigo trata-se de um relato de experiência sobre o projeto “Qualidade de Vida” no Programa de Residência Multiprofissional em Saúde Mental do Adulto (PRMSMA), do Distrito Federal, no qual, o Diagnóstico Situacional apontou uma lacuna na “qualidade de vida dos residentes”. Diante do cenário político, econômico e pós-pandêmico, o adoecimento mental de residentes tem sido potencializado. O principal objetivo consiste em propiciar a “ética do cuidado” na residência, através de um espaço de construção coletiva, pautado na Psicodinâmica do Trabalho. Inicialmente, contextualiza-se o mercado de trabalho e a escolha pela residência multiprofissional. Em seguida, pontua-se a lógica capitalista que atravessa a proposta da residência multiprofissional de profissionais para o SUS, partindo da descrição de oito encontros realizados com residentes na modalidade online e presencial. Finalmente, discute-se o impacto da ética do cuidado, da clínica da cooperação na saúde mental destes residentes como abordagem possível na residência.