bluuebunny/crossref_metadata_2025_split huggingface dataset:
An improved particle swarm optimizer for inverse kinematics of manipulator
Authors: Li Zhentao , Wang Panfeng , Feng Yun , Zhang Guanjun , Guo Zhiyang , Zhang Minghui , Zhang Yi 
Published: November 2023

Abstract
Swarm intelligence optimization algorithms have been proven to significantly improve the efficiency and accuracy of solving inverse kinematics problems for manipulators. This is of great importance for research in the fields of manipulator trajectory tracking control and path optimization. Distinguished from conventional swarm intelligence algorithms, the improved particle swarm algorithm proposed in this study uses adaptive inertia weight and asynchronous learning factors to update the particle speed during particle evolution, better balancing global and local search capabilities. At the same time, the idea of generating new offspring by mutation is introduced into particles to enhance the diversity of the population and reduce the possibility of particles falling into local optima. The algorithm's performance was assessed through its application to 13 classical benchmark functions. The obtained results were subsequently compared with the outcomes of genetic algorithms, particle swarm algorithms, and their respective variations. The results suggest that the improved particle swarm algorithm demonstrates significantly better convergence speed and accuracy on most functions in comparison to alternative algorithms (Wilcoxon rank-sum test, α=0.05). Finally, a collaborative manipulator experimental platform was established to assess the efficacy of the improved particle swarm algorithm in solving the inverse kinematics of the manipulator. The findings suggest that the improved particle swarm algorithm demonstrated superior accuracy in solving the inverse kinematics of the manipulator in a shorter duration, yielding errors of less than 0.1 mm, which lays an important foundation for improving the trajectory tracking control accuracy and path planning efficiency of the manipulator.
Identification of a Functional circRNA-miRNA-mRNA Network and Inhibitory Effect of Hsa_circ_0001681 on Gliomas
Authors: Cheng Lilin , Chen Xu , Sun Wenhua , Hu Xiang , Zhang Shuai , Wu Hui 
Published: November 2023

Abstract
Background
Gliomas seriously threaten the health and safety of patients globally with significant morbidity and mortality. An increasing number of studies have confirmed the close correlation between circular RNAs (circRNAs) and the occurrence and development of cancer. However, the association between circRNAs and their downstream networks with gliomas remains unclear.
Results
Our study identified 4 significantly differentially expressed circRNAs through the glioma expression profile from the Gene Expression Omnibus database. A total of 125 circRNA-targeted microRNAs (miRNAs) were predicted using the Circular RNA Interactome database, 15 of which were selected for further mining from intersection analysis. A total of 2635 miRNA-targeted mRNAs were predicted using the miRNet database, thus establishing the circRNA-miRNA-mRNA network. Functional enrichment pathway analyses revealed that the mRNAs contained in the network were enriched in a variety of DNA- or RNA-related transcription regulatory processes and pathways in cancer. Hsa_circ_0001681 was further identified as a hub circRNA and validated by Sanger sequencing and RT-PCR. Cell biology experiments and xenograft models revealed that hsa_circ_0001681 played an anticarcinogenic role in gliomas both in vitro and in vivo.
Conclusions
Our results identified and indicated the crucial role of circRNA-miRNA-mRNA network in gliomas and supported the potential of hsa_circ_0001681 as a diagnostic and therapeutic target biomarker.
Boric Acid Alleviates Periodontal Inflammation Induced by IL-1β in Human Gingival Fibroblasts
Authors: Bozkurt Serife Buket , Hakki Sema S. , Nielsen Forrest H 
Published: November 2023

Abstract

Boric acid (BA) has been found to have therapeutic effects on periodontal disease through beneficially affecting antibacterial, anti-viral, and anti-inflammatory actions. Thus, a study was conducted to determine the effect of BA on cell viability and on mRNA expressions of proinflammatory and anti-inflammatory cytokines and on oxidative stress enzymes induced by IL-1β (1ng/mL) in Human Gingival Fibroblasts (HGF) cultured for 24 and 72 hours in DMEM media. The BA concentrations added to the media were 0.09%, 0.18%, 0.37%, and 0.75%. All of the BA concentrations increased the viability of cell cultured in DMEM media only, indicating that these concentrations were not toxic and actually beneficial to cell viability. The addition of 1 ng/m: of IL-1β decreased cell viability that was overcome by all concentrations of BA at both 24 and 72 hours. The IL-1β addition to the media increased the expressions of the proinflammatory cytokines IL-1β, IL-6, IL-8, and IL-17; the anti-inflammatory cytokine IL-10; and the oxidative stress enzymes superoxide dismutase (SOD0 and glutathione peroxidase (GPX). The IL-1β induced increase mRNA expression of IL-1β was decreased at 24 hours by the 0.37% and 0.75% BA additions to the media and decreased in a dose-dependent manner by all concentrations of BA at 72 hours. The IL-1β induced increase in the expression of IL-6 was decreased in dose-dependent manner at 72 hours by BA. All BA concentrations decreased the IL-1β induced expression of IL-8 at both 24 and 72 hours. The induced increase in IL-17 by IL-1β was not significantly affected by the BA additions. The increase in the anti-inflammatory cytokine IL10 induced by IL-1β was increased further by all BA additions in dose dependent manner at both 24 and 72 hours. The mRNA expressions of SOD and GPX increased by IL-1β were further increased by the 0.37% and 0.75% BA concentrations at 72 hours. These findings indicate that BA can significantly modulate the cytokines that are involved in inflammatory stress and reactive oxygen species action and thus could be an effective therapeutic agent in the treatment of periodontal disease.
Biomechanical Effects of Evans versus Hintermann Osteotomy for Treating Adult Acquired Flatfoot Deformity: A Patient-Specific Finite Element Investigation
Authors: Xu Can , Liu Hua , Li Mingqing , Li Hui , Pan Chunang 
Published: November 2023

Abstract
Background
Evans and Hintermann lateral column lengthening (LCL) procedures are both widely used to correct adult acquired flatfoot deformity (AAFD), and have both shown good clinical results. The aim of this study was to compare these two procedures in terms of corrective ability and biomechanics influence on the Chopart and subtalar joints through finite element (FE) analysis.
Methods
Twelve patient-specific FE models were established and validated. The Hintermann osteotomy was performed between the medial and posterior facets of the subtalar joint, while the Evans osteotomy was performed on the anterior neck of the calcaneus around 10 mm from the calcaneocuboid joint surface. In each procedure, a triangular wedge of varying size was inserted at the lateral edge. The two procedures were then compared based on the measured strains of superomedial calcaneonavicular ligaments and planter facia, the talus-first metatarsal angle, and the contact characteristics of talonavicular, calcaneocuboid and subtalar joints.
Results
The Hintermann procedure achieved a greater correction of the talus-first metatarsal angle than Evans when using grafts of the same size, indicating that Hintermann had stronger corrective ability. However, its distributions of von-Mises stress in the subtalar, talonavicular and calcaneocuboid joints were less homogeneous than those of Evans. In addition, the strains of superomedial calcaneonavicular ligaments and planter facia of Hintermann were also greater than those of Evans, but both generally within the safe range (less than 6%).
Conclusion
This FE analysis study indicates that both Evans and Hintermann procedures have good corrective ability for AAFD. Compared to Evans, Hintermann can provide a stronger corrective effect while causing greater disturbance to the biomechanics of Chopart joints, which may be an important mechanism of arthritis.
Clinical Relevance:
Both Evans and Hintermann LCL surgeries have a considerable impact on adjacent joints and ligament tissues. Such effects alongside the overcorrection problem should be cautiously considered when choosing the specific surgical method.
Level of Evidence:
Level III, case-control study.
Theft Detection using Deep Learning
Authors: Shirole Sairaj 
Published: November 2023

Abstract
In earlier times, crime detection relied solely onhuman observation, lacking efficient methods for detection. Theadvent of CCTV cameras marked a significant advancement incrime detection, but the manual review of video footage byhumans proved to be a time-consuming process. In presentworld, Artificial Intelligence (AI) and Machine Learning (ML)have made significant strides, the need for intelligent systems toautomate crime detection in CCTV surveillance has becomeparamount. Such systems can not only detect crimes but alsoclassify them and provide alerts to nearby police stations andambulances, thereby contributing to the reduction of crimerates in any given country. Object detection and tracking incomputer vision have gained widespread attention due to theirdiverse applications, including surveillance and securitysystems. Researchers have diligently worked to improve theaccuracy and efficiency of these processes. Our system aims toenhance security measures and facilitate swift responses topotential threats by employing real-time object detection on livevideo feeds. Furthermore, this system can be further optimizedthrough the integration of specialized hardware, ensuring evenmore robust and efficient crime detection capabilities.
ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Estrogen Receptor Positive Breast Cancer
Authors: Patel Roshni , Alfarsi Lutfi H. , Ansari Rokaya El , Masisi Brendah K. , Erkan Busra , Fakroun Ali , Ellis Ian O. , Rakha Emad A. , Green Andrew R. 
Published: November 2023

Abstract

Purpose:
ATF4, a stress-responsive transcription factor that upregulates adaptive genes, is a potential prognostic marker and modulator of glutamine metabolism in breast cancer. However, its exact role remains to be elucidated.
Methods:
ATF4 expression was evaluated at genomic and transcriptomic levels using METABRIC (n=1980), GeneMiner (n=4712) and KM-Plotter datasets. Proteomic expression was assessed via immunohistochemistry (n=1341) in the Nottingham Primary Breast Carcinoma Series. ATF4 genomic copy number (CN) variation and mRNA/protein in association with clinicopathological parameters, amino acid transporters (AATs), and patient outcome was investigated.
Results:
Genomic, transcriptomic, and proteomic overexpression of ATF4 was associated with more aggressive ER-negative tumours. ATF4 mRNA and protein expression were significantly associated with increased expression of glutamine related AATs including SLC1A5 (p<0.01) and SLC7A11 (p<0.02). High ATF4 and SLC1A5 protein expression was significantly associated with shorter breast cancer-specific survival (p<0.01), especially in ER+ tumours (p<0.01), while high ATF4 and SLC7A11 protein expression was associated with shorter survival (p<0.01).
Conclusion:
These findings suggest a complex interplay between ATF4 and AATs in breast cancer biology and underscore the potential role for ATF4 as a prognostic marker in ER+ breast cancer, offering a unique opportunity for risk stratification and personalised treatment strategies.
Use of an Antibacterial Mouthwash Alters the Gut Microbiome, Reduces Nutrient Absorption and Attenuates Diet-induced Obesity
Authors: Carlstrom Mattias , Carvalho Lucas , Boeder Ariela , Shimari Miho , Kleshchev Andrey , Esberg Anders , Johansson Ingegerd , Weitzberg Eddie , Lundberg Jon 
Published: November 2023

Abstract
Prolonged use of antibacterial mouthwash is linked to increased risk of systemic disease. We aimed to investigate if disturbing the oral microbiota would impact the lower gut microbiome with functional effects in diet-induced obesity. Mice were exposed to oral chlorhexidine and fed a Western diet. Food intake and weight gain were monitored, and metabolic function, blood pressure and microbiota were analyzed. Chlorhexidine reduced oral bacteria and altered parts of the gut microbiota known to be associated with metabolic pathways. Chlorhexidine reduced weight gain, body fat, steatosis, and plasma insulin without changing caloric intake, while increasing colon triglycerides and proteins demonstrating reduced absorption of these nutrients. The mechanisms behind these effects as well as the link between the oral microbiome and small intestinal function need to be pinpointed. While short-term effects of chlorhexidine in this model appear beneficial, potential long-term disruptions in the oral and gut microbiota and possible malabsorption should be considered.
Neutrophils Seeking New Neighbors - Radiotherapy Affects the Cellular Framework and the Spatial Organization in a Murine Breast Cancer Model
Authors: Reichardt C. M. , Muñoz-Becerra M. , Rigau A. Rius , Rückert M. , Fietkau R. , Schett G. , Gaipl U. , Frey B. , Muñoz L. E. 
Published: November 2023

Abstract
Neutrophils are known to contribute to many aspects of tumor progression and metastasis in cancer. The presence of neutrophils or neutrophil-derived mediators in the tumor microenvironment has been associated with poor prognosis in several types of solid tumors. Nonetheless, the effects of cancer treatments such as radiotherapy on neutrophils has not been studied yet. Furthermore, the cellular composition and distribution of immune cells in the tumor is of increasing interest in cancer research and new imaging technologies allow to perform more complex spatial analyses within tumor tissues. Therefore, we aim to offer novel insight into intra-tumoral formation of cellular neighborhoods and communities in murine breast cancer. We used the TS/A breast cancer tumor model for our analyses. We performed image mass cytometry and spatial neighborhood analyses of the tumor microenvironment and quantified NET-degradation products in serum. We show that radiotherapy of 2x8 Gy significantly alters the cellular composition and spatial organization in the tumor, especially of neutrophils. Locally applied radiotherapy further affects neutrophils in a systemic manner by decreasing the serum neutrophil extracellular trap concentrations which correlates positively with survival. In addition, the intercellular cohesion is maintained after radiotherapy as shown by E-Cadherin expression via the TGF-β/SMAD axis which potentially prevents metastasis. We conclude that radiotherapy-modulated cellular composition and spatial distribution of immune cells, particularly that of neutrophils and macrophages in connection to T cells has to be considered more. This sheds light on potential mechanisms that influence treatment outcomes and metastatic potential of solid tumors such as breast cancer.
Ethanol extract of Alpiniae oxyphyllae fructus regulates glucose metabolism, the HPA axis and hippocampal function in diabetic mice with depression
Authors: Zhou Qilun , Qi Yue , Deng Jinlan , Li Ruonan , Zhang Yongping , Zhang Xiaofeng 
Published: November 2023

Abstract

Background: Alpiniae oxyphyllae fructus (AOF) is the dry ripe fruit of Alpinia oxyphylla Miq. which has significant therapeutic effects in Alzheimer's disease, Parkinson's disease, depression, learning and memory dysfunction and other nervous system disease.
Methods: In this study, we established a mouse model of Type 2 Diabetes Mellitus (T2DM) combined with depression induced by feeding high fat and high sugar diet combined with intraperitoneal injection of streptozotocin (STZ) and chronic unpredictable mild stress (CUMS) to evaluate the dual therapeutic effects of ethanol extract of AOF (EEA), and further explore the mechanism of EEA on diabetes complicated with depression.
Results: The results showed that EEA improved the body weight of diabetic mice with depression (DD mice). EEA could also improve glucose metabolism and insulin resistance in DD mice. Next, EEA improved the depression-like behaviors of DD mice. EEA also attenuated diabetes and CUMS-induced hyperactivity of the hypothalamic-pituitary-adrenal(HPA) axis and improved the expression of neurotransmitters and synaptic plasticity in the hippocampus of DD mice. In addition, EEA could improve hippocampal tissue damage caused by neuroinflammation and oxidative stress. Further research showed that EEA improved the protein expression and phosphorylation of Phosphoinositide 3-kinase (PI3K), Protein kinase B (Akt) and Mammalian target of rapamycin (mTOR) in the hippocampus of DD mice.
Conclusions: This study showed that EEA may have a dual role in the treatment of diabetes and depression and provided new scientific theoretical basis for the future development of AOF and the prevention and treatment of diabetes complicated with depression.
Heat transport process associated with the 2021 eruption of Aso volcano revealed by thermal and gas monitoring
Authors: Narita Shohei , Yokoo Akihiko , Ohkura Takahiro , Morita Masaaki , Mori Toshiya , Yoshikawa Shin 
Published: November 2023

Abstract

The thermal activity of a magmatic–hydrothermal system commonly changes at various stages of volcanic activity. Few studies have provided an entire picture of the thermal activity of such a system over an eruptive cycle, which is essential for understanding the subsurface heat transport process that culminates in an eruption. This study quantitatively evaluated a sequence of thermal activity associated with two phreatic eruptions in 2021 at Aso volcano. We estimated plume-laden heat discharge rates and corresponding H2O flux during 2020–2022 by using two simple methods. We then validated the estimated H2O flux by comparison with volcanic gas monitoring results. Our results showed that the heat discharge rate varied substantially throughout the eruptive cycle. During the pre-eruptive quiescent period (June 2020–May 2021), anomalously large heat discharge (300–800 MW) were observed that were likely due to enhanced magma convection degassing. During the run-up period (June–October 2021), there was no evident change in heat discharge (300–500 MW), but this was accompanied by simultaneous pressurization and heating of an underlying hydrothermal system. These signals imply progress of partial sealing of the hydrothermal system. In the co-eruptive period, the subsequent heat supply from a magmatic region resulted in additional pressurization, which led to the first eruption (October 14, 2021). The heat discharge rates peaked (2000–4000 MW) the day before the second eruption (October 19, 2021), which was accompanied by sustained pressurization of the magma chamber that eventually resulted in a more explosive eruption. In the post-eruptive period, enhanced heat discharge (~ 1000 MW) continued for four months, and finally returned to the background level of the quiescent period (< 300 MW) in early March 2022. Thus, despite using simple models, we quantitatively tracked transient thermal activity and revealed the underlying heat transport processes throughout the Aso 2021 eruptive activity.
Mycoplasma hyopneumoniae - a neglected disease as a cause of fibrinous pericarditis in weaned piglets: An etio-pathological assessment
Authors: Patel Shailesh Kumar , Sahoo Monalisa , Pathak Mamta , Saikumar G. , Thakor Jigarji Chaturji , Dinesh M. , Anbazhagan Subbaiyan , Singh Rajendra , Singh Karampal , Patel Sagar , Sahoo Prabin Kumar , Pasayat Mamata , Sahoo Nihar 
Published: November 2023

Abstract
Fibrinous pericarditis, predominantly of bacterial origin, is frequently documented in slaughtered pigs causing great economic loss to the pig production. The present report describes the rare cases of Mycoplasma hyopneumoniaeinduced fibrinous pericarditis in post-weaned crossbred piglets (n=7). The piglets showed the lesions of fibrinous pericarditis, sac effusions (blood and serosanguineous), heavy non-collapsible lungs, and fibrinous hepatitis. Microscopically, sub-acute fibrinous pericarditis, pleuritis, broncho-interstitial pneumonia, hepatitis, fibrinous polyserositis, lymphocyte depletion and enteritis were characteristic lesions. Immunohistochemical staining showed abundant immunoreactivity of M. hyopneumoniae antigen in the infiltrating mononuclear cells of heart, bronchiolar epithelium and cellular exudates of lungs, and lymphocytes of lymphoid organs. The etiological confirmation of M. hyopneumoniae in all the tissues by the PCR test showed amplification of 853bp targeting the p36 gene. The phylogenetic tree showed 99.30% homology with that of M. hyopneumoniae sequences in the database. The other likely aetiologies like PM, APP, SS, HPS, B. bronchiseptica, Chlamydia, PRRSV, SIV, and ECMV were tested negative by PCR, except for PCV2 in lung samples. This paper highlights the importance of M. hyopneumoniae in the differential diagnosis of fibrinous pericarditis in piglets.
The Clinical Efficacy of Sustentaculum Tali Screws in Calcaneal Fractures
Authors: Li Zihua , Xiao Fajiao , Huang Hui , Xia Jiang , Zhou Haichao , Li Bing , Yang Yunfeng 
Published: November 2023

Abstract
Background
To investigate whether accurate placement of sustentaculum tali screws have the impacts on the clinical efficacy of calcaneal fractures.
Methods
A retrospective analysis of 72 cases (73 feet) of calcaneal fractures from September 2015 to September 2019 treated with open reduction and internal fixation with sustentaculum tali screws was conducted. Patients were divided into the sustentaculum tali fixation group (ST group) and the sustentaculum fragment fixation group (STF group) according to the location of the sustentaculum tali screw placement. The functional outcomes at preoperative, 7 days and 1 year postoperative were collected and analyzed.
Results
In the ST group (40 feet), the Gissane's angle altered from (109.89 ± 12.13) ° to (121.23 ± 9.34) ° and (119.08 ± 8.31) ° at 7 days and 1 year postoperative, respectively. For Böhler's angles altered from (11.44 ± 5.94) °, to (31.39 ± 7.54) °, and (30.61 ± 7.94) ° at 7 days and 1 year postoperative, respectively. In the STF group (33 feet), Gissane's angle altered from (110.47 ± 14.45) °, to (122.08 ± 8.84) °, and (120.67 ± 9.07) ° and Böhler's angle altered from (11.32 ± 6.77) °, to (28.82 ± 8.52) °, and (28.25 ± 9.13) ° (P < 0.001). However, there was no statistically significant difference in functional outcomes at 1 week after surgery and 1 year after surgery (P > .05). The AOFAS scores at the final follow-up of the two groups: ST group (88.95 ± 6.16) and STF group (89.78 ± 8.76); VAS scores, ST group (0.83 ± 0.98) and STF group (1.03 ± 1.59), all differences were not statistically significant (P > .05).
Conclusion
The position of sustentaculum tali screws has no significant difference on the short-term clinical outcome in patients with calcaneal fractures, while reliable fixation of screws to sustentaculum tali fragment can achieve similar clinical outcome.
Level of Evidence: V