bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of influencing factors of industrial green and low-carbon transformation under the background of “double carbon”: evidence from Sichuan province, China
Authors: Liu Bo , Chang Haodong , Li Yan , Zhao Yipeng 
Published: October 2023

Introduction: Industrial green and low-carbon transformation is the key to improve economic development and necessary process to achieve the goal of the carbon peaking and carbon neutrality. Few studies have been done on the decomposition of carbon emission factors in industries and sub-industries and the impact of green and low-carbon transformation about carbon emission in each industry quantitatively. However, the study of industries and sub-industries can comprehensively analyze the development path of green and low-carbon transformation from a more detailed perspective, and provide scientific reasons for the optimization of industrial structure and energy structure.Methods: The extended Kaya identity for industrial carbon emission is constructed to obtain four factors influencing industrial carbon emission: economic output effect, industrial structure effect, energy intensity effect, carbon consumption intensity in this paper. Then, the LMDI decomposition method is combined with the above identity to innovatively obtain the contribution value of carbon emissions from the perspective of overall, industrial sector and tertiary industry. Then, based on the results of factor decomposition, a multi-index scenario prediction model is constructed. On this basis, the extreme learning machine model optimized by particle swarm optimization (PSO-ELM) was used to predict the influence of the changes in the driving factors on the reduction of industrial carbon emissions. By setting the baseline and industrial green and low-carbon transformation scenarios, it is predicted that industrial carbon emission in Sichuan Province.Results and discussion: (1) Economic output effect always promotes the growth of industrial carbon emissions, and with the adjustment of industrial structure and energy structure, the other three factors begin to restrain the growth of carbon emissions. (2) Scenario prediction shows that without considering the economic costs of transformation, improving carbon emission reduction efficiency can be obtained through accelerating the rate of change of industrial structure of the secondary and tertiary industries, increasing the proportion of energy intensity reduction, and strengthening the proportion of non-fossil energy use.
Global systematic map of research on bats in agricultural systems
Authors: Xavier Bruna Silva , Rainho Ana , Santos Ana M. C. , Vieira Marcus Vinícius , Carvalho William Douglas 
Published: October 2023

IntroductionThe conversion of natural habitats to agricultural systems is one of the main global threats to bats. Here, we aimed to develop a systematic mapping to identify publication trends and research gaps in studying bats and agricultural systems.MethodsWe reviewed 309 studies published between 1990 and 2021 that sampled bats in agricultural systems or evaluated the effect of these systems on these animals.ResultsWe found that most studies were conducted in the Palearctic and Neotropical regions (55.3%) and forest biomes (66.0%). Grassland-cropland systems (50.2%) and forest plantations that do not require cutting during the extraction of their products (47.9%) were more studied than forest plantations that require cutting (19.7%). Additionally, acoustic recordings (41.1%) and mist nets (34.3%) were the primary sampling methods used, with few studies combining these methods (7.1%). Also, most studies were conducted on a local scale (77.7%). The number of landscape-scale studies was smaller (34.3%) and concentrated in the Palearctic region (39.6%). Most studies assessed how agricultural systems affect biodiversity (62.1%). However, the phylogenetic and functional dimensions and b-diversity were little explored, with 2.5% and 23.3% of the biodiversity studies, respectively. Of the proposed mitigation measures, the most cited was including natural/semi-natural/potential bat habitats in cultivated landscapes (59.5%).DiscussionIn summary, our findings highlight the need for attention to the Afrotropic and Indo-Malaysia regions; predominantly non-forested biomes; plantations that require cutting during the extraction of their products; combined use of different sampling methods, as well as other methods as telemetry; use of multiple biodiversity descriptors and others biological descriptors, such as ecological services; landscape-scale studies and the role of conservation policies in promoting their conservation and raising awareness of their importance among producers and local communities. Filling these knowledge gaps is necessary to understand the factors influencing bat survival in cultivated landscapes. This is the only way to develop management and conservation strategies in these landscapes.
The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
Authors: Sun Wanli , Yang Fan , Yang Yiyuan , Su Xin , Xing Yanwei 
Published: October 2023

Background: Multiple observational studies have discovered a substantial link between obstructive sleep apnea (OSA) and ventricular dysfunction. However, conventional observational studies are vulnerable to causal reversal and confounding, making it challenging to infer the causes of effects and their direction.Methods: With the help of a bidirectional, two-sample Mendelian randomization (MR) study, we assessed the potential causality between OSA and left and right ventricular (LV, RV) structure and function. We conducted our analysis utilizing summary data from genome-wide association studies of OSA (16,761 cases and 201,194 controls) in the FinnGen Study, as well as LV (36,041 participants) and RV (29,506 participants) in the UK Biobank cardiovascular magnetic resonance research. The inverse variance weighted (IVW) was selected as the main strategy, with the MR-Egger and weighted median methods serving as supplements. Other methods were employed as sensitivity analysis tools to look at heterogeneity and pleiotropy, including MR-Egger intercept, Cochran Q statistic, MR-PRESSO, and leave-one-out analysis.Results: In the primary IVW analysis, genetically predicted OSA was strongly causative on LV end-diastolic volume (β = 0.114, 95% CI = 0.034–0.194, p = 0.006) and LV stroke volume (β = 0.111, 95% CI = 0.031–0.191, p = 0.007), and genetically predicted LV ejection fraction was linked to an increased risk of OSA (OR = 1.161, 95% CI = 1.029–1.309, p = 0.015). However, there was no connection found between OSA and any RV parameters.Conclusion: Our genetic analysis raises a potential causative link between OSA and ventricular structure and function, which may improve the knowledge of OSA as a risk factor for cardiovascular disease by demonstrating a direct impact on cardiac structure and function.
MAIT cells altered phenotype and cytotoxicity in lupus patients are linked to renal disease severity and outcome
Authors: Litvinova Elena , Bounaix Carine , Hanouna Guillaume , Da Silva Jennifer , Noailles Laura , Beaudoin Lucie , Padden Michael , Bellamri Nessrine , Lehuen Agnès , Daugas Eric , Monteiro Renato C. , Flament Héloïse 
Published: October 2023

IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disease in which circulating immune complexes can cause different types of glomerulonephritis, according to immune deposits and to the type of glomerular cell injury. Proliferative lesions represent the most severe form of lupus nephritis (LN) and often lead to kidney failure and death. Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T cells that recognize microbial-derived ligands from the riboflavin synthesis pathway. Although abundant in peripheral blood, MAIT cells are enriched in mucosal and inflamed tissues. While previous studies have reported concordant results concerning lower MAIT cell frequencies in the blood of SLE patients, no information is known about MAIT cell function and LN severity and outcome.MethodsIn the current study, we analyzed the baseline phenotype and function of peripheral blood MAIT cells by flow cytometry in 26 patients with LN and in a control group of 16 healthy individuals.ResultsWe observe that MAIT cell frequencies are markedly reduced in blood of LN patients. MAIT cells from patients have an altered phenotype in terms of migration, proliferation and differentiation markers, notably in most severe forms of LN. Frequencies of PMA/ionomycin stimulated MAIT cells secreting effector molecules, such as proinflammatory IL-17 and cytotoxic protein granzyme B, are higher in LN patients. Patients undergoing a complete renal remission after immunosuppressive therapy had higher MAIT cell frequency, lower expression of proliferation marker Ki-67 and granzyme B (GzB) at inclusion. Remarkably, GzB production defines a predictive model for complete remission.DiscussionWe report here that blood MAIT cells display proinflammatory and cytotoxic function in severe lupus nephritis which may play a pathogenesis role, but without association with systemic lupus activity. Finally, low cytotoxic profile of MAIT cells may represent a promising prognostic factor of lupus nephritis remission one year after induction therapy.
Post-stroke dysphagia and ambient air pollution are associated with dementia
Authors: Lee Kuo-Wei , Chung Hao-Wei , Hsieh Hui-Min , Tsao Yu-Hsiang , Hung Chih-Hsien , Feng Ming-Chu , Hung Chih-Hsing 
Published: October 2023

IntroductionThis cohort study aimed to explore the potential association between ambient air pollution and dementia incidence in adults who have experienced a stroke. Additionally, the study aimed to determine dysphagia as a predictive factor for the subsequent development of dementia in patients with stroke.Materials and methodsThis retrospective nested case–control study used data from the Kaohsiung Medical University Hospital Database in Taiwan. Data collected include average ambient air pollution concentrations within 3 months and 1 year after the index dysphagia date. The primary outcome includes incident dementia in patients with or without dysphagia. Logistic regression analysis was performed to examine the association between significant air pollution exposure and the risk of dementia while controlling for baseline demographic characteristics (age and sex), and comorbidities.ResultsThe univariable regression models revealed a higher likelihood of dementia diagnosis in patients with dysphagia (odds ratio = 1.493, 95% confidence interval = 1.000–2.228). The raw odds ratios indicated a potential link between air pollution exposure and elevated dementia risks in the overall study population and patients with stroke without dysphagia, except for O3. Particulate matter (PM)2.5 and nitrogen oxides (NOx) exhibited significant effects on the risk of dementia in the stepwise logistic regression models.ConclusionThe presence of dysphagia following a stroke may pose a risk of developing dementia. Additionally, PM2.5 and NOx exposure appears to elevate the risk of dementia in patients with stroke.
Regional white matter hyperintensity volume predicts persistent cognitive impairment in acute lacunar infarct patients
Authors: Li Tan , Ye Mengfan , Yang Guopeng , Diao Shanshan , Zhou Yun , Qin Yiren , Ding Dongxue , Zhu Mo , Fang Qi 
Published: October 2023

BackgroundWhite matter hyperintensity (WMH) is often described in acute lacunar stroke (ALS) patients. However, the specific relationship between regional WMH volume and persistent cognitive impairment remains unclear.MethodsWe enrolled patients with ALS who were hospitalized at the First Affiliated Hospital of Soochow University between January 2020 and November 2022. All patients were assessed for global cognitive function using the Montreal Cognitive Assessment (MoCA) scale at 14 ± 2 days and 6 months after the onset of ALS. Manifestations of chronic cerebral small vessel disease (CSVD) were assessed via MRI scan. The distributions of regional WMH were segmented, and their relationship with cognitive impairment was evaluated.ResultsA total of 129 patients were enrolled. Baseline frontal WMH volume (OR = 1.18, P = 0.04) was an independent risk factor for long-term cognitive impairment after ALS. Furthermore, the presence of WMH at the genu of the corpus callosum (GCC) at baseline (OR = 3.1, P = 0.033) was strongly associated with persistent cognitive decline. Multivariable logistic regression analysis showed that depression (OR = 6.252, P = 0.029), NIHSS score (OR = 1.24, P = 0.011), and albumin at admission (OR = 0.841, P = 0.032) were also important determinants of long-term cognitive impairment after ALS.ConclusionsOur study found that WMH, especially frontal WMH volume and the presence of WMH at the GCC at baseline, independently contributed to long-term cognitive decline in ALS patients. This study provides new evidence of the clinical relationship between regional WMH volume and cognitive impairment in ALS patients.
Radiotherapy dosimetry and radiotherapy related complications of immediate implant-based reconstruction after breast cancer surgery
Authors: Zhang Yu , Ye Fuxiu , Teng Yun , Zheng Jin , Li Chunlu , Ma Ruilan , Zhang Haichen 
Published: October 2023

BackgroundsThe impact of immediate implant-based breast reconstruction (IBBR) on the delivery of radiotherapy plans remains controversial. This study aimed to compare the differences in radiotherapy dosimetry, complications of radiotherapy, and quality of life in patients who underwent modified radical mastectomy combined with or without IBBR.MethodsWe retrospectively collected 104 patients with breast cancer who underwent intensity-modulated radiation therapy after modified radical mastectomy with IBBR (n =46) or not (n =58) from January 2017 to December 2021. The dosimetric differences in radiotherapy of planning target volume (PTV) and organs at risk and the differences in complications of radiotherapy between the two groups were compared. We also applied the functional assessment of cancer therapy-breast cancer (FACT-B) score to compare the difference in quality of life. The chi-square test and independent samples t-test were used to analyze the above data.ResultsIBBR group was associated with higher PTV volumes, PTV D98, V95, and lower PTV Dmean, D2 compared with the non-reconstruction group (P&lt;0.05). IBBR group also had lower radiotherapy dosimetric parameters in the ipsilateral lung and the heart of left breast cancer patients. The differences in the rates of radiation pneumonia (RP) and radiation dermatitis (RD) between the two groups were not statistically significant (P &gt; 0.05). Moreover, FACT-B scores at 6 months after radiotherapy in patients with IBBR were higher than those without reconstruction (P &lt; 0.05).ConclusionPatients with IBBR achieved better radiation dosimetry distribution and higher quality of life without more complications of radiotherapy.
Hepatic arterial infusion chemotherapy versus systemic therapy for advanced hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Kim Hyeon-Jong , Lee Seung Hyuk , Shim Hyun Jeong , Bang Hyun Jin , Cho Sang Hee , Chung Ik-Joo , Hwang Eu Chang , Hwang Jun Eul , Bae Woo Kyun 
Published: October 2023

IntroductionTo investigate the effects of hepatic arterial infusion chemotherapy (HAIC) with or without systemic chemotherapy compared to systemic chemotherapy alone in patients with locally advanced hepatocellular carcinoma (HCC).MethodsFollowing a registered protocol (PROSPERO 2023 CRD42023386780 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023386780), a comprehensive search was performed using reputable databases and registries up to December 26, 2022, with no language, publication date, or status restrictions. Only randomized controlled trials (RCTs) investigating the effects of HAIC with or without systemic chemotherapy versus systemic therapy alone were included. The primary outcomes were overall survival (OS), progression-free survival (PFS), and adverse events. The secondary outcomes included the objective response rate (ORR) and disease control rate (DCR). A random-effects model was used, and the certainty of the evidence was rated using GRADE.ResultsSeven RCTs involving 1,010 patients were included. All trials utilized sorafenib as the comparator. Five trials (690 patients) compared HAIC plus sorafenib to sorafenib alone, while two trials (320 patients) compared HAIC to sorafenib. The results indicate that HAIC, with or without sorafenib, may increase OS, PFS, and ORR compared with sorafenib alone. HAIC may enhance DCR, but the evidence is very uncertain. Adverse events were comparable between HAIC plus sorafenib and sorafenib alone. However, adverse events might be decreased in HAIC alone.DiscussionHAIC with or without systemic chemotherapy may improve survival outcomes and response rates of patients with HCC. Since the current body of evidence is moderate to very low, more robust randomized trials are needed to confirm the efficacy of HAIC.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=386780, identifier CRD42023386780.
Clinical characteristics and proposed mechanism of pediatric spinal cord injury resulting from backbend practice
Authors: Guo Shuang , Gong Huiming , Xu Peipei , Xie Yang , Yang Degang , Liu Zitong , Yang Yuwei , Chen Liang , Xie Yongqi , Yang Mingliang 
Published: October 2023

ObjectivePediatric spinal cord injury without radiographic abnormality (SCIWORA) caused by backbend practice is increasing. This study proposed an underlying ‘combined injury mechanism’ related to the spinal cord and femoral nerve overstretching.MethodsPediatric patients diagnosed with backbend-associated SCIWORA at the China Rehabilitation Research Center during 2017–2021 were recruited. Clinical and imaging data were collected, and each patient's clinical course and prognosis were determined. Healthy dancers were recruited to simulate the backbend, obtain images, and estimate the spinal cord and femoral nerve stretch ratio. A model for the ‘combined injury mechanism’ was established using 4-week-old SD rats.ResultsForty-two SCIWORA female patients with an average age of 6 (SD 1) years and an average hospitalization time of 91 (SD 43) days were assessed. The primary initial symptom was pain in the back and/or lower extremities (33, 79%). The average time from injury onset to severe paralysis was 2.0 (SD 0.6) hours. Most patients had complete paraplegia (32, 76%), and neurological levels were distributed mainly in thoracic segments (38, 91%). Patients with elicited tendon reflexes on admission tended to have an incomplete spinal cord injury (p = 0.001) and improved motor recovery (p = 0.018). After one year, the most common complications were scoliosis (31, 74%) and abnormal hips (14, 33%). Injury of the caudal spinal cord torn by nerve roots was confirmed by surgical exploration in a case. The thoracic spinal cord and femoral nerves were overstretched by 148.8 ± 3.6% and111.7 ± 4.0%, respectively, in a full backbend posture. The ‘combined injury mechanism’ was partially replicated in the animal model.ConclusionSpinal overstretch and transient dislocation are considered the primary mechanisms by which SCIWORA occurs in children. Overstretching the femoral nerve aggravates spinal cord injuries caused by backbend practice.
Total kinetic energy release in the fast neutron induced fission of actinide nuclei
Authors: Loveland Walter 
Published: October 2023

The total kinetic energy release and fission mass distributions for the fast neutron (En = 3–100 MeV) induced fission of 232Th, 233U, 235U, 237Np, 239Pu, 240Pu, and 242Pu have been measured using the LANSCE facility. The neutron energies were deduced from time-of- flight measurements. The fission fragments were detected using Si PIN diode detectors, giving us the fragment energies. The actinide targets were made by vapor deposition leading to high-quality targets, that were thin and uniform with reduced impurities. Corrections were made to the data for pulse height defect and the fragment energy loss in the target and its backing. The TKE distributions were Gaussian in shape and their mean value as a function of incoming neutron energy could be fitted with second order polynomials. In the case of 233U and 235U, our measurements agree with prior work. Our measurements for 232Th are unique. Our data agree with Viola scaling. The constant position of the heavy mass peak is interpreted as being due to the influence of the N = 88 and Z = 50 shells. The GEF model predictions agree with the data in general as do the CGMF model predictions.
Role of monocytes/macrophages in renin-angiotensin system-induced hypertension and end organ damage
Authors: Barhoumi Tlili , Todryk Stephen 
Published: October 2023

Graphical AbstractRole of monocytes/macrophages in renin-angiotensin system-induced hypertension and end organ damage. RAS activation induces monocyte/macrophage pro-inflammatory-like phenotype polarization, directly and indirectly via cytokines (MCP-1, CCR2, IL-1b). Activation manifests in fibrosis, oxidative stress, endothelial dysfunction and low grade inflammation (IL-6, TNFa) and tus end organ damage. (HTA hypertension).
Age-matched versus non-age-matched comparison of clinical and functional differences between delusional disorder and schizophrenia: a systematic review
Authors: Hui Christy Lai Ming , Chiu Tsz Ching , Chan Evie Wai Ting , Hui Priscilla Wing Man , Tao Tiffany Junchen , Suen Yi Nam , Chan Sherry Kit Wa , Chang Wing Chung , Lee Edwin Ho Ming , Chen Eric Yu Hai 
Published: October 2023

BackgroundIt has been widely suggested that delusional disorder (DD) differs from schizophrenia (SZ). However, whether the two disorders are truly distinct from each other is inconclusive as an older age of onset is closely linked to a better prognosis in psychotic disorders. In order to delineate the potential influence of age on outcomes, we undertook a systematic review on the clinical and functional differences between DD and SZ in age-matched and non-age-matched cohorts.MethodsElectronic databases were retrieved up to May 2022. Included studies were analyzed with reference to statements about clinical, cognitive and functional differences between DD and SZ.ResultsData synthesized from 8 studies showed (1) extensive effects of age on positive, general psychopathological symptoms and functioning, but (2) consistent differences between the two disorders in terms of negative symptoms and hospitalizations regardless of age matching.ConclusionThere is currently insufficient evidence to conclude whether DD is completely distinct from SZ, but our review showed support for the confounding effect of age in comparisons of psychotic disorders with different ages of onset. Future studies shall take note of other possible confounding variables, methods of age-matching and the importance of longitudinal information in deducing whether the two disorders differ from each other in course and outcome.