bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Fingerprints and Data Mining-based Prediction of Some Bioactive Compounds from Allium sativum as Histone Deacetylase 9
(HDAC9) Inhibitors
Authors: Das Totan , Bhattacharya Arijit , Jha Tarun , Gayen Shovanlal 
Published: February 2024

Background:
Histone deacetylase 9 (HDAC9) is an important member of the class
IIa family of histone deacetylases. It is well established that over-expression of HDAC9 causes
various types of cancers including gastric cancer, breast cancer, ovarian cancer, liver cancer,
lung cancer, lymphoblastic leukaemia, etc. The important role of HDAC9 is also recognized in
the development of bone, cardiac muscles, and innate immunity. Thus, it will be beneficial to
find out the important structural attributes of HDAC9 inhibitors for developing selective
HDAC9 inhibitors with higher potency.

Methods:
The classification QSAR-based methods namely Bayesian classification and recursive
partitioning method were applied to a dataset consisting of HADC9 inhibitors. The structural
features strongly suggested that sulphur-containing compounds can be a good choice for
HDAC9 inhibition. For this reason, these models were applied further to screen some natural
compounds from Allium sativum. The screened compounds were further accessed for the ADME
properties and docked in the homology-modelled structure of HDAC9 in order to find important
amino acids for the interaction. The best-docked compound was considered for molecular
dynamics (MD) simulation study.

Results:
The classification models have identified good and bad fingerprints for HDAC9 inhibition.
The screened compounds like ajoene, 1,2 vinyl dithiine, diallyl disulphide and diallyl trisulphide
had been identified as compounds having potent HDAC9 inhibitory activity. The results
from ADME and molecular docking study of these compounds show the binding interaction
inside the active site of the HDAC9. The best-docked compound ajoene shows satisfactory
results in terms of different validation parameters of MD simulation study.

Conclusion:
This in-silico modelling study has identified the natural potential lead (s) from Allium
sativum. Specifically, the ajoene with the best in-silico features can be considered for further
in-vitro and in-vivo investigation to establish as potential HDAC9 inhibitors.
Genotype and Phenotype Association Analysis Based on Multi-omics Statistical Data
Authors: Guo Xinpeng , Song Yafei , Xu Dongyan , Jin Xueping , Shang Xuequn 
Published: February 2024

Background:
When using clinical data for multi-omics analysis, there are issues such as
the insufficient number of omics data types and relatively small sample size due to the protection of
patients' privacy, the requirements of data management by various institutions, and the relatively
large number of features of each omics data. This paper describes the analysis of multi-omics pathway
relationships using statistical data in the absence of clinical data.

Methods:
We proposed a novel approach to exploit easily accessible statistics in public databases.
This approach introduces phenotypic associations that are not included in the clinical data and uses
these data to build a three-layer heterogeneous network. To simplify the analysis, we decomposed
the three-layer network into double two-layer networks to predict the weights of the inter-layer associations.
By adding a hyperparameter β, the weights of the two layers of the network were
merged, and then k-fold cross-validation was used to evaluate the accuracy of this method. In calculating
the weights of the two-layer networks, the RWR with fixed restart probability was combined
with PBMDA and CIPHER to generate the PCRWR with biased weights and improved accuracy.

Results:
The area under the receiver operating characteristic curve was increased by approximately
7% in the case of the RWR with initial weights.

Conclusion:
Multi-omics statistical data were used to establish genotype and phenotype correlation
networks for analysis, which was similar to the effect of clinical multi-omics analysis.
Biogenic Synthesis and Characterization of Ethyl Ferulate Gold Nanoparticle and its Efficacy against Triple-Negative Breast Cancer Cells
Authors: Unnikrishnan Jyothsna , Hegde Mangala , Kumar Aviral , Girisa Sosmitha , Satpati Priyadarshi , Kunnumakkara Ajaikumar B. 
Published: February 2024

Background:
Triple-Negative Breast Cancer (TNBC) presents a significant challenge
due to its aggressive nature and lack of responsive hormone receptors, predominantly affecting
younger premenopausal women. Ethyl ferulate (EF), a notable phytochemical, has demonstrated
promising anti-cancer properties. This study aimed to enhance the efficacy of EF by synthesizing
and characterizing ethyl ferulate gold nanoparticles (EF-AuNps) to passively target TNBC cells
via the enhanced permeability and retention (EPR) effect.

Methods:
We synthesized EF-AuNps using a direct reduction method and characterized the NPs
by employing various techniques, including UV-visible spectroscopy, DLS, XRD, EDX, TEM,
and FT-IR. The anti-proliferative activity against MDA-MB-231 cells was assessed using MTT
and colony formation assays, alongside evaluating cell viability with PI-FACS and live/dead assays.
Furthermore, a Western blot was performed to determine the mechanism of action of EFAuNps
in TNBC cells.

Result:
We successfully synthesized triangular EF-AuNps (< 100nm) and observed a substantial inhibition
of cell proliferation (IC50 18μg/ml). Compared to EF alone, EF-AuNps significantly enhanced
cell death in TNBC cells, as confirmed by flow cytometry and viability assays. Besides,
Western blot analysis verified that the expression of apoptotic-related signal proteins, such as survivin,
caspase 3, and caspase 9, were modulated by EF-AuNps.

Conclusion:
EF-AuNps showed higher anti-cancer efficacy than EF in the MDA-MB-231 cell
line. These findings suggest the therapeutic potential of EF-AuNps for TNBC treatment, advocating
for further preclinical and clinical investigations into this promising anti-cancer formulation.
Remote Sensing Revolution: Mapping Land Productivity and Vegetation
Trends with Unmanned Aerial Vehicles (UAVs)
Authors: Harle Shrikant , Bhagat Amol , Dash Ashish Kumar 
Published: February 2024

Abstract:
This review paper offers a comprehensive exploration of the multifaceted applications of
Unmanned Aerial Vehicles (UAVs) in various domains, showcasing their transformative impact in
addressing complex challenges. The evaluation of cloud-based UAV systems' stability reveals their
robustness and reliability, underlining their significance in numerous industries. Additionally, their
role in enhancing robot navigation in intricate environments signifies a substantial advancement in
robotics and automation. The integration of blockchain technology for secure Internet of Things
(IoT) data transfer emphasizes the critical importance of data integrity and confidentiality in the IoT
era. Furthermore, the optimization of energy-efficient data collection in IoT networks through UAVs
demonstrates their potential to revolutionize data-driven decision-making processes, particularly in
fields reliant on data accuracy and timeliness. The paper also highlights the application of deep reinforcement
learning to enhance UAV-assisted IoT data collection, showcasing the synergy between
advanced machine learning techniques and UAV technology. Finally, the discussion underscores the
pivotal role of UAVs in precision agriculture, where they facilitate ecological farming practices and
monitor environmental conditions, contributing to the pursuit of sustainable and efficient agriculture.
This review reaffirms UAVs' status as transformative tools, reshaping industries and unlocking new
frontiers of innovation and problem-solving. With ongoing technological advancements, UAVs are
poised to play an increasingly central role in a wide range of applications, promising a future marked
by ground breaking possibilities. Key findings include the dominance of the United States and China
in the field, exploration of characteristics such as crop production, and innovative UAV-based methods
for grassland mapping, maize growth assessment, and Arctic plant species monitoring. The research
underscores the potential of UAVs in bridging field data and satellite mapping, providing
valuable insights into diverse applications, from soil analysis to yield predictions, highlighting their
transformative role in environmental monitoring and precision agriculture
Studies of Social Anxiety Using Ambulatory Assessment: Systematic Review
Authors: Fernández-Álvarez Javier , Colombo Desirée , Gómez Penedo Juan Martín , Pierantonelli Maitena , Baños Rosa María , Botella Cristina 
Published: February 2024

Background
There has been an increased interest in understanding social anxiety (SA) and SA disorder (SAD) antecedents and consequences as they occur in real time, resulting in a proliferation of studies using ambulatory assessment (AA). Despite the exponential growth of research in this area, these studies have not been synthesized yet.

Objective
This review aimed to identify and describe the latest advances in the understanding of SA and SAD through the use of AA.

Methods
Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic literature search was conducted in Scopus, PubMed, and Web of Science.

Results
A total of 70 articles met the inclusion criteria. The qualitative synthesis of these studies showed that AA permitted the exploration of the emotional, cognitive, and behavioral dynamics associated with the experience of SA and SAD. In line with the available models of SA and SAD, emotion regulation, perseverative cognition, cognitive factors, substance use, and interactional patterns were the principal topics of the included studies. In addition, the incorporation of AA to study psychological interventions, multimodal assessment using sensors and biosensors, and transcultural differences were some of the identified emerging topics.

Conclusions
AA constitutes a very powerful methodology to grasp SA from a complementary perspective to laboratory experiments and usual self-report measures, shedding light on the cognitive, emotional, and behavioral antecedents and consequences of SA and the development and maintenance of SAD as a mental disorder.
Problemas académicos de estudiantes irregulares relacionados con el uso del tiempo en la Facultad de Medicina de la UNAM
Authors: Hamui Sutton Alicia , Aguirre-Hernández Rebeca , Díaz-Villanueva Arturo , Ramírez-de la Roche Omar Fernando , Gómez-Lamont Danae Sofía 
Published: February 2024

Introducción: El estudio del uso de tiempo permite apreciar características del desempeño académico de los estudiantes de medicina, así como la duración de las actividades que realizan.
Objetivo: Identificar asociaciones estadísticas significativas entre problemas académicos y la condición de ser estudiante irregular (recursador).Material y métodos: Estudio descriptivo, transversal y comparativo. Se autoaplicó un cuestionario con 103 preguntas entre octubre y diciembre de 2008, a los alumnos de la Facultad de Medicina de la UNAM. De primer año respondieron 1 309 de 1 555 inscritos (84%), de segundo 682 de 927 (73%), de tercer 806 de 850 (94%) y de cuarto año 531 de 802 (66%). Con las bases de datos generadas, se elaboraron tablas de contingencia y se exploraron asociaciones significativas en el uso del tiempo de los alumnos regulares e irregulares con la prueba estadística de ji cuadrada (p<0.05).Resultados: De 3 029 encuestados, 13% fueron recursadores, de los cuales 80.7% estaban en primer año, 70.2% eran mujeres. El 50.6% tenían promedio de calificaciones menor de siete, en comparación los regulares, 17.2% (p=0.00). Se encontró asociación estadísticamente significativa (p<0.05) entre algunos problemas académicos y ser recursador, como dificultad para entender textos médicos, realizar maniobras clínicas, buscar apoyo en libros adicionales o internet, y la necesidad de asesoría para organizar su tiempo. Los irregulares se mostraron inseguros de terminar la carrera y expresaron disfrutar menos sus estudios.
Conclusiones: Los recursadores presentaron problemas complejos que incluyeron dificultades en habilidades psicomotoras, cognitivas y en aspectos logísticos que bloquearon la búsqueda de soluciones, lo que conllevó bajas calificaciones y desmotivación.
Conocimiento sobre el Catálogo Maestro de Guías de Práctica Clínica del Centro Nacional de Excelencia Tecnológica en Salud (CENETEC-México) en estudiantes de Medicina
Authors: Vázquez-Cantú Bárbara Viviana , Muñoz-Zurita Guillermo 
Published: February 2024

Introducción: La modalidad medicina basada en evidencias (MBE) conlleva al uso juicioso de la investigación clínica, para la orientación y toma de decisiones adecuadas relacionadas al cuidado de la salud. En México, el Centro Nacional de Excelencia Tecnológica en Salud (CENETEC) proporciona información basada en la evidencia disponible a través del Catálogo Maestro de Guías de Práctica Clínica (GPC), con el objetivo de orientar al médico en el diagnóstico, tratamiento y manejo de pacientes con padecimientos específicos.Objetivo: Identificar el conocimiento de estudiantes de medicina sobre las GPC del CENETECMéxico. Material y métodos: Estudio observacional, unicéntrico y transversal en 150 alumnos de la Facultad de Medicina de la Benemérita Universidad Autónoma de Puebla (BUAP). Se aplicó una encuesta orientada hacia el conocimiento acerca de la MBE y la existencia de las GPC, para favorecer la toma de decisiones clínicas. La población estudiantil analizada pertenece al nivel formativo de acuerdo al plan de estudios de la Institución (sexto y décimo cuatrimestre).Resultados: Cuarenta y seis estudiantes (30.6%) tienen conocimiento sobre la existencia de GPC-CENETEC. De éstos, el 21.7% las conoció por medios de comunicación, el 50% por medio de un médico, el 10.8% por amigo/compañero y el 17.5% por familiares. El 58.7% piensa que las GPC son completas y orientan a un diagnóstico más preciso. El 43.4% considera que las GPC no pueden aplicarse a todo tipo de pacientes. El 67.5% las usaría como único recurso para el tratamiento de enfermedades. El 87% sí las tomaría en cuenta para futuros diagnósticos. El 67.5% las consideraría porque aportan mayor confianza, y el 65.2% recomendaría su utilización.
Conclusión: El conocimiento por parte de los estudiantes de Medicina acerca de las GPC es limitado.
De estudiante a especialista: ¿salto cuántico o paso de tortuga?
Authors: Sánchez-Mendiola Melchor 
Published: February 2024

A lo largo de mi trayectoria clínica y académica, he tenido la fortuna de vivir intensamente las diferentes etapas del proceso clínico, educativo y de investigación, y a estas alturas de la vida (con la magia del “retroscopio”, quegeneralmente nos da una perspectiva de entendimiento difícil de lograr en el momento agudo) me he puesto a pensar sobre lo terriblemente complejo que es integrar todos los elementos que confluyen en el profesional de la salud ideal: clínico, investigador, docente (y discente vitalicio).
Desempeño histórico de egresados de una universidad mexicana en el examen de residencias médicas, 2001-2013
Authors: Jiménez-Sastré Alejandro , Quevedo‑Tejero Elsy Del Carmen , Hernández-Ortega Hilda María , Fócil-Némiga Eduardo , Zavala-González Marco Antonio 
Published: February 2024

Objetivo: Analizar el desempeño histórico de los egresados de la Universidad Juárez Autónoma de Tabasco (UJAT) en el Examen Nacional de Aspirantes a Residencias Médicas (ENARM).
Método: Se realizó una investigación cuantitativa, empleando un diseño transversal, en la que se determinó la proporción de egresados que han aprobado el ENARM durante el período 2001-2013, así como la evolución histórica de la calificación obtenida en esta prueba, ambas, en relación con otras universidades nacionales. Los resultados del ENARM fueron obtenidos del sitio web de la Comisión Interinstitucional para la Formación de Recursos Humanos para la Salud (CIFRHS), mientras que los egresados de la UJAT, lo fueron de la Coordinación de Estudios Terminales de Médico Cirujano de esta universidad. Los datos se analizaron mediante estadística descriptiva.
Resultados: 2,828 Médicos Cirujanos egresaron durante el período y 4,490 presentaron el ENARM. La media de seleccionados fue de 11.3% ± 3.0% dentro de un intervalo de 6.0% (en 2004) a 15.6% (en 2012); en todos los casos fue menor a la media nacional. El puntaje medio obtenido fue de 44.59 ± 7.57 dentro de un intervalo de 35.63 (en 2004) a 54.65 (en 2012); en todos los casos fue menor a la media nacional.
Conclusiones: La proporción de egresados de la UJAT seleccionados en el ENARM es baja, al igual que sus puntajes en la prueba. El número de sustentantes sobrepasa al de egresados anualmente. Se sugiere realizar seguimiento de egresados, así como promover posgrados orientados a la investigación y especialidades no mediadas por el ENARM.
Improved Glycemic Outcomes With Diabetes Technology Use Independent of Socioeconomic Status in Youth With Type 1 Diabetes
Authors: Lomax Kate E. , Taplin Craig E. , Abraham Mary B. , Smith Grant J. , Haynes Aveni , Zomer Ella , Ellis Katrina L. , Clapin Helen , Zoungas Sophia , Jenkins Alicia J. , Harrington Jennifer , de Bock Martin I. , Jones Timothy W. , Davis Elizabeth A. ,   Australasian Diabetes Data Network (ADDN) Study Group, Anderson Kym , Andrikopoulos Sof , Ambler Geoff , Barrett Helen , Batch Jenny , Bergman Philip , Cameron Fergus , Conwell Louise , Cotterill Andrew , Cooper Chris , Couper Jennifer , Craig Maria , Davis Elizabeth , de Bock Martin , Fairchild Jan , Fegan Gerry , Fourlanos Spiros , Glastras Sarah , Goss Peter , Gray Leonie , Hamblin Peter Shane , Hofman Paul , Holmes-Walker Dianne Jane , Huynh Tony , Isaacs Sonia , Jefferies Craig , Johnson Stephanie , Jones Tim , Kao Jeff , King Bruce R. , Lafferty Antony , Makin Jane , Martin Michelle , McCrossin Robert , Neville Kris , Pascoe Mark , Paul Ryan , Pawlak Dorota , Peña Alexia , Phillips Liza , Price Darrell , Rodda Christine , Simmons David , Sinnott Richard , Smart Carmel , Stell Anthony , Stone Monique , Stranks Steve , Tham Elaine , Waddell Barbara , Ward Glenn , Wheeler Ben , Woodhead Helen , Zimmermann Anthony 
Published: February 2024

OBJECTIVE
Technology use in type 1 diabetes (T1D) is impacted by socioeconomic status (SES). This analysis explored relationships between SES, glycemic outcomes, and technology use.

RESEARCH DESIGN AND METHODS
A cross-sectional analysis of HbA1c data from 2,822 Australian youth with T1D was undertaken. Residential postcodes were used to assign SES based on the Index of Relative Socio-Economic Disadvantage (IRSD). Linear regression models were used to evaluate associations among IRSD quintile, HbA1c, and management regimen.

RESULTS
Insulin pump therapy, continuous glucose monitoring, and their concurrent use were associated with lower mean HbA1c across all IRSD quintiles (P &lt; 0.001). There was no interaction between technology use and IRSD quintile on HbA1c (P = 0.624), reflecting a similar association of lower HbA1c with technology use across all IRSD quintiles.

CONCLUSIONS
Technology use was associated with lower HbA1c across all socioeconomic backgrounds. Socioeconomic disadvantage does not preclude glycemic benefits of diabetes technologies, highlighting the need to remove barriers to technology access.
Ponies, miniatures, and younger equids are at higher risk of fecalith obstruction compared to a general colic population
Authors: Miklavcic Mitja , Dechant Julie E. , Kilcoyne Isabelle 
Published: February 2024

Abstract

OBJECTIVE
To determine breed, age, and sex predispositions for fecalith obstruction and to evaluate short-term survival and prognostic factors following surgical treatment of fecalith intestinal obstruction in equids.

ANIMALS
151 equids.

METHODS
Medical records of equids undergoing surgery for fecalith obstruction from 2000 to 2020 were reviewed. Signalment, history, presenting clinicopathological data, surgical findings, complications, and short-term survival were recorded and compared between survivors and nonsurvivors. Signalment of the fecalith population was compared to a contemporaneous colic population. Clinical factors were assessed for association with outcome.

RESULTS
64 females, 53 castrated males, and 31 intact males were included. Three equids presented twice. Miniature horses, ponies, and miniature donkeys/mules represented 48% (71/148) of fecalith population and full-sized breeds represented 52% (77/148). Miniature horses and ponies were overrepresented and equids ≤ 1 year of age were overrepresented in the fecalith population compared to the colic population. One hundred thirty-nine equids (92%) survived to discharge, 6% (9/148) were euthanized intraoperatively, and 2% (3/148) were euthanized during hospitalization. Nonsurvivors showed more severe colic signs on admission, tachycardia on admission, and hyperlipemia. Equids with postoperative colic (P = .01) and complications (P = .002) were less likely to survive.

CLINICAL RELEVANCE
Miniature horses and ponies were overrepresented compared to the colic population; however, full-sized breeds were also affected. Surgical treatment had an excellent short-term prognosis. Severe colic signs, tachycardia, hyperlipemia, postoperative colic, and surgical complications negatively affected short-term survival.
Minimally invasive splenectomy is associated with a low perioperative complication rate and short operative time in cats
Authors: Fairfield Danielle K. , Singh Ameet , Hawker William , Richardson Danielle , Mayhew Philipp , Balsa Ingrid , Culp William T. N. , Cinti Filippo , Buote Nicole J. , Massari Federico , Griffin Maureen A. , Gibson Erin , Runge Jeffrey J. , Chanoit Guillaume 
Published: February 2024

Abstract

OBJECTIVE
To report the perioperative outcome and complications in cats undergoing minimally invasive splenectomy.

ANIMALS
17 client-owned cats.

METHODS
Perioperative data were collected from cats undergoing minimally invasive splenectomy from September 2010 to June 2023. Data included history, signalment, preoperative examination and diagnostic testing results, operative technique and time, perioperative outcomes, complications, hospitalization duration, histopathological diagnosis, and outcome.

RESULTS
13 spayed females and 4 neutered males were included, with a median age of 144 months (48 to 196 months). Seven cats underwent total laparoscopic splenectomy (TLS), with 1 cat requiring conversion from TLS to laparoscopic-assisted splenectomy (LAS) due to splenomegaly and an additional cat requiring conversion from TLS to open splenectomy due to uncontrollable splenic capsular hemorrhage. Ten cats underwent LAS, with 1 cat requiring conversion to open splenectomy due to splenomegaly. Additional procedures were performed in 13 cats, with the most common being liver biopsy in 10 cats. Median operative times were 50 minutes (45 to 90 minutes) for TLS and 35 minutes (25 to 80 minutes) for LAS. An intraoperative complication occurred in 1 cat. All but 1 cat survived to discharge. Median follow-up time was 234 days (18 to 1,761 days), with 15 of 16 cats confirmed alive at 30 days and 9 of 16 cats alive at 180 days postoperatively.

CLINICAL RELEVANCE
Minimally invasive splenectomy in this cohort of cats was associated with short operative times and a low perioperative complication rate. Veterinary surgeons may consider minimally invasive splenectomy as an efficient and feasible technique in the treatment of splenomegaly or modestly sized splenic masses for diagnostic and therapeutic purposes in cats.