bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amelioration of Ophthalmoplegic Migraine by Prednisone: A Case Report
Authors: Smith Charles D. , Reeves Alexander G. 
Published: June 2005

SYNOPSISA 42‐year‐old patient with a 40‐year history of paroxysmal headache associated with recurrent rightabducens palsy was treated with prednisone for three days following headache onset. Initiation ofprednisone within four hours of headache onset resulted in decreased severity and duration of theheadache and prevention or marked amelioration of the ophthalmoparesis. Therapy delayed beyondeighteen hours had a much less dramatic effect.
Thomas Willis', Two Chapters on Headache of 1672: A First Attempt to Apply the “New Science” to this Topic
Authors: Isler Hansruedi 
Published: June 2005

SYNOPSISMTo most physicians, Thomas Willis (1621–1675) is only known for the Circle of Willis, but he achievedmuch more: he was one of the three great clinicians of 17th‐century England, and the founder of modernbrain anatomy and clinical neurology. He coined the word “neurology,” discovered reflex action, and wrotethe first textbook of clinical neurology. He made use of an imaginary neurophysiological framework whichenabled him to anticipate numerous discoveries of the 19th century.The first two chapters of the clinical part of his textbook deal with headache. Wolff's hypothesis,“complete migraine,rdquo; the slow spreading of focal symptoms, the cerebral origin of vomiting, and clusterperiodicity are found to be anticipated, at least in part. The combination of hypothetical pathophysiologyand arbitrary nosology is quite suggestive of the present situation, although the system is different.The review is based on the original Latin text of 1672.
Dexamethasone Suppression Test in Cluster Headache
Authors: Devoize Jean‐Louis , Rigal François , Eschalier Alain , Zarifian E. , Tournilhac Michel 
Published: June 2005

SYNOPSISThe dexamethasone suppression test was performed on eleven patients with cluster headache. Interest in such investigation of the hypothalamo‐pituitary‐adrenal axis in cluster headache arose from both a certain analogy with manic‐depressive disorders and recent data on abnormal patterns of cortisol secretion in cluster headache. Investigation results were normal in all patients, showing that the hypothalamo‐pituitary‐adrenal dysfunction reported in depressions is not a biological feature of cluster headache.
Calcitonin and Migraine
Authors: Patti Francesco , Scapagnini Umberto , Nicoletti Francesco , Prato Agata , Millia Claudio , Clementi Giuseppe 
Published: June 2005

SYNOPSISA group of 30 patients (12 M ‐ 18 F) suffering from migraine underwent salmon calcitonin therapy for a period of one month. All patients were treated at first for 30 days with vehicle administration in a daily i.m. injection, as a control. Calcitonin effectiveness was evaluated in terms of changes in frequency, intensity and duration of the migraine attacks. The results show a significant difference between the observation period (vehicle only) and treatment phase, with improvement during the calcitonin treatment.
Bilateral Sympathetic Dysfunction in Post‐Traumatic Headaches
Authors: Khurana Ramesh K. , Nirankari Varinder S. 
Published: June 2005

SYNOPSISTwo patients developed generalized throbbing headaches, tenderness of the anterior neck and unilateral ptosis following whiplash injury. They were systematically evaluated for involvement of the central nervous system, carotid arteries, vagi and cervical sympathetic nerves. Biochemical study of pupils revealed bilateral postganglionic Horner's syndrome. Thermal‐induced facial sweating showed supraorbital anhidrosis. Follow‐up 18 to 54 months after injury demonstrated partial improvement in pupillary functions and headaches but persistent supraorbital anhidrosis. Pertinent literature on sympathetic dysfunction and post‐traumatic headaches is reviewed, and the reasons and implications for sympathetic involvement in hyperextension‐hyperflexion injury are discussed.
Basilar Artery Migraine: EEG and Evoked Potential Patterns During Acute Stage
Authors: Ganji S. 
Published: June 2005

SYNOPSISElectroencephalographic and evoked potential studies were done during the ictal phase of migraine in a 22‐year‐old woman with basilar artery migraine. Prominent posterior slowing was seen in the EEG pattern during the symptomatic period. Clinical improvement coincided with the reversal of abnormality in the EEG tracing. The findings from the multimodality evoked potentials were within normal limits.
Duration of Postural Headache After Lumbar Puncture: Effect of Needle Size
Authors: Kovanen Jussi , Sulkava Raimo 
Published: June 2005

SYNOPSISThe effect of needle size on postural headache after diagnostic lumbar puncture was studied in 300 patients at the Outpatient Department of Neurology, University of Helsinki. In three groups of 100 patients a needle size of 0.9mm (20 gauge), 0.7mm (22 gauge) and 0.6mm (23 gauge) were used, respectively. The total number of days with incapacitating postural headache in the groups diminished significantly with the decreasing needle size from 282 through 181 to 76 days. An analysis of CT scans performed in 95 patients showed that the incidence of post‐lumbar puncture headache significantly decreased with brain atrophy seen on CT independently of the needle size. The results suggest that the thinnest needle (0.6mm) usable without special techniques should be chosen for diagnostic lumbar punctures at outpatient departments.
Sublingual Flunarizine: a New Effective Management of the Migraine Attack. A Comparison versus Ergotamine
Authors: Bonuso Salvatore , Stasio Emanuela Di , Marano Enrico , Sorge Fulvio , Leo Alfonso 
Published: June 2005

SYNOPSISFlunarizine was found to be effective in the acute treatment of isosorbide dinitrate induced migraine attacks, when given in a dosage of 10 mg sublingually.The present study consists of two parts: in the first preliminary investigation, 7 out of 8 migraine patients who developed a typical migraine attack after isosorbide dinitrate were relieved of pain within about 10 minutes. On the basis of this result a second, randomized controlled open trial was performed, in which the acute efficacy of flunarizine was compared with ergotamine tartrate, 0.25 mg i.m., on 40 migraine patients. Flunarizine was found as effective as ergotamine (75% positive responses in the flunarizine group, 70% in the ergotamine group). The mean latency of the flunarizine effect was significantly lower than that of the ergotamine ( r < 0.001, Student's t test). Moreover sublingual flunarizine was found to be virtually devoid of side effects.
Glucose and Diet in the Fasting Migraineur
Authors: Marsters J.B. , Mortimer M.J. , Hay K.M. 
Published: June 2005

SYNOPSISIn migraine, are there different metabolic responses to glucose ingestion, and if so, do the patients have different detectable characteristics which may be of use to determine their treatment?Thirty two volunteer migraineurs, for whom fasting was a known precipitant, were challenged with a glucose meal after an overnight fast. Symptoms and glucose levels were recorded at intervals over three hours. Examination of the changes in symptoms, elicited two groups with opposite responses, which were also significantly different with respect to circulating glucose levels. Furthermore, sub‐groups defined by dietary precipitants as expressed by the migraineur, were also found to be significantly different in both of these parameters.A treatment plan, for this type of migraine attack, based on the the dietary factors which may provoke its evolution and the response to glucose, is discussed.
Post‐Traumatic Headache Patients II: Special Problems, Perceptions, and Service Needs
Authors: Barnat Michael R. 
Published: June 2005

SYNOPSISMuch of the research literature on the psychology of chronic headache focuses on the obsessionalism and/or general neuroticism of the sufferers. More recently, some work has shifted the focus to other aspects of the clinical picture, e.g., what, in the aggregate, headache patients want out of treatment, and how they view treatment and their own disorders.As an extension of this recent line of inquiry, the present study was designed to provide data on post‐traumatic headache patients, their “special problems, perceptions and service needs.” The respondents, described in a previous report: “Post‐traumatic headache patients I: Demographics, injuries, headache and health status,” were new and return patients in a headache treatment center. In the course of a twelve month period, the opinions of one hundred seventeen patients were sampled.The present report describes the following areas: patients' perceptions of their general progress toward recovery, sources of health care information relevant to their condition, patients' adequacy of communication about their condition, service needs, concurrent sources of care, areas of functional improvement, present life adjustment, and anticipations of the future.
A Wellness Program in the Treatment of Headache
Authors: Simons Alan , Solbach Patricia , Sargent Joseph , Malone Leslie 
Published: June 2005

SYNOPSISThe development of a wellness program for the treatment of headache at the Headache Center of theMenninger Foundation progressed through a series of steps based on research and clinical experience. Initialfeedback from participants suggested that some positive changes were started because of the program butthat the program did not help maintain such changes.Wellness is defined and is described in its possible applications to the treatment of headache. Traditionalbarriers to the clinical employment of such applications are also described. A survey of the literature exploresthose barriers and possible reasons why such barriers need no longer interfere with employing a wellnessprogram in supplementing existing treatment.Recommendations are given based on the survey of literature and clinical experience.
Tension Headaches: Relation Between MMPI Paranoïa Score and Pain and Between MMPI Hypochondriasis Score and Frontalis EMG
Authors: Collet L. , Cottraux J. , Juenet C. 
Published: June 2005

SYNOPSISThe relation between MMPI, frontal EMG and pain is examined in 25 subjects with tension headaches. Our results point to an association between high levels of weekly pain and high paranoïa scores (p < .01) but fail to confirm previous reports on the correlation of pain with hypochondriasis, depression and hysteria. This finding is discussed in terms of a reciprocal pain/personality relation. The results also show that the only correlation to be found for frontal EMG is that with hypochondriasis MMPI scores (p < .01).
Autonomic Dysfunction in Adult Migraineurs
Authors: Havanka‐Kanniainen H. , Tolonen U. , Myllylä V.V. 
Published: June 2005

SYNOPSISThe autonomic nervous system (ANS) functions of 60 migraine patients, aged from 23 to 50 years, wereinvestigated during headache‐free intervals by utilizing a number of cardiovascular reflexes as indices.Thirty‐five healthy subjects of similar age served as a control group. The pulse rate (R‐R‐interval) variationwas recorded in normal and deep breathing, in the Valsalva manoeuvre, and in an orthostatic test (a tilttable was used); and the blood pressure reactions were recorded in an orthostatic test and in an isometricwork (hand grip) test.There were significant differences in the results between migraine patients and control subjects in theR‐R‐interval variation ratio, both in normal and deep breathing tests and in the Valsalva manoeuvre. Thedifferences between migraine patients and controls in pulse rate variation in orthostatic test and in bloodpressure reactions in isometric work test were highly significant (p < 0.001 ). There were no statisticallysignificant differences in cardiovascular reflex responses of various subgroups of migraine patients(common‐classic, frequent‐infrequent attacks, normal‐abnormal EEGs). These results suggest mildparasympathetic hypo function, but more definite sympathetic hypofunction (Valsalva manoeuvre,orthostatic test and isometric work test) in adult migraine patients during headache‐free intervals.
The Non‐epileptiform Basilar Artery Migraine
Authors: Jacome Daniel E. , Risko Marlyn 
Published: June 2005

SYNOPSISFive patients with basilar artery migraine (BAM) are described. One, while exhibiting electroencephalographic(EEG) interictal discharges and photo‐paroxysmal responses entirely suppressed by carbamazepine orvalproate, had no improvement of her attacks. Subsequent therapy with propanolol did improve the attacksdespite persistence of EEG abnormalities. A second patient had paroxysmal abnormalities and improved withisometheptene mucate. Three other patients had normal ictal and interictal EEGs, including after activationprocedures. A population of patients with basilar artery migraine exists with normal EEG recordings or withparoxysmal activity independent from that of migraine; these patients may respond to drugs other thananticonvulsants.
Pattern‐Shift Visual Evoked Responses and EEG in Migraine
Authors: Polich John , Ehlers Cindy L. , Dalessio Donald J. 
Published: June 2005

SYNOPSISVisual evoked responses (VERs) and spectral analysis of background EEG were obtained from 20migraine patients and their age‐matched controls. Full‐ and half‐field reversing checkerboardstimulus presentations elicited no substantial differences between the subject groups for any of themajor component (N75, P100, N145) latencies or amplitudes. No VER differences were found forpatient subcategories based on side of headache, symptom history, or age. However, migrainepatients demonstrated slight but significantly higher mean frequency in their background EEG in the4–8 Hz frequencies in leads C 3 ‐P 3 and C 4 ‐P 4 , and a lower mean frequency in the 8–12 Hz band inleads F 3 ‐C 3 and F 4 ‐C 3 relative to controls. The results are discussed and compared to previousstudies of visual evoked potentials and EEG in migraine patients.
Leukotriene B4 Generation by Polymorphonuclear Leukocytes: Possible Involvement in the Pathogenesis of Headache
Authors: Selmaj K. , De Belleroche J. , Das I. , Rose F. Clifford 
Published: June 2005

SYNOPSISLeukotriene B4 (LTB4) levels in plasma and its generation in vitro from isolated polymorphonuclearleukocytes (PMN) were measured in migraine and cluster headache patients during and between painattacks. The LTB4plasma levels in cluster headache patients during an attack were significantly higherthan in patients between attacks. There was a positive correlation between the time of sampling from thebeginning of attack and the LTB4level. The LTB4 plasma levels in migraine patients during and betweenattacks did not differ significantly from control levels. The results suggest that LTB4appears rapidly in thecirculation at the beginning of a cluster attack and thereafter declines in amount. LTB4release from PMNwas induced by stimulation with the calcium ionophore A23187. The release of LTB4was significantlyhigher in migraine patients during attacks on stimulation with a submaximal dose of A23187 0.5 μM. LTB4 release induced by A23187 in migraine patients during symptom‐free intervals and cluster headachepatients did not differ from healthy controls. LTB4 release was not affected by 5HT and NA inconcentrations up to 10‐4M. The results suggest that LTB4is more easily generated in migraine patientsduring attacks. These studies on isolated cells provide a suitable model for the investigation of themetabolism of lipoxygenase derivates in headache patients.
Familial Hemiplegic Migraine: A New Case
Authors: Bergouignan Francois‐Xavier , Ferrer Xavier , Julien Jean 
Published: June 2005

SYNOPSISThe definition of familial hemiplegic migraine is still unsettled. We report the case of a young man who has had hemiplegic migraine attacks for ten years. CT of the brain was abnormal with a low density in the temporal lobe, suggesting infarction and probably having no relation to the attacks. There was a clear family history of hemiplegic migraine, possibly with the same type of attack. Ergotamine tartrate seemed to be effective in preventing headache. This case challenges the current clinical definition of familial hemiplegic migraine, in that while the attack pattern was hereditary, the hemiplegia occurred as an aura rather than accompanying and outlasting the headache.
The Time Relationships of Migraine and Cluster Headache When Occurring in the Same Patient
Authors: Solomon Seymour , Cappa Karen Guglielmo 
Published: June 2005

SYNOPSISOf 1,688 patients with migraine or cluster headache, 16 (one percent) had a history of both. In 14 of the 16 patients, migraine occurred first and was either replaced by cluster headache (7 patients) or continued during the years of cluster headache (7 patients). In one patient, migraine and cluster headache began at the same time and in one patient, cluster headache preceded migraine. A review of the literature reveals a similar sequence of migraine almost always preceding cluster headache when the two occur in the same patient.The relationships between migraine and cluster headache are discussed. In rare instances, cluster headache appears to evolve from migraine.
Idiopathic Headaches: Relationship to Life Events
Authors: Nattero G. , Lorenzo C. De , Biale L. , Torrie E. , Ancona M. 
Published: June 2005

SYNOPSIS228 patients were interviewed using Paykel's list. The aim of this study was to detect possible differences among vascular, tension and tension‐vascular headaches with special attention to stressing events preceding the onset of headache.The statistical analysis of the results showed significant differences among the groups studied for the weight of life events in the 10 years prior to the onset of headache. Minor differences emerged for the year immediately prior to the headache onset. Particular differences were also observed in the distribution of life events with the aid of qualitative analysis.Worthy of notice is the fact that the migraineurs tested resuIted to be less damaged by stress than the other patients.
Basilar Artery Migraine After Uncomplicated Whiplash Injuries
Authors: Jacome Daniel E. 
Published: June 2005

SYNOPSISFour female patients with basilar artery migraine (BAM) developing after isolated whiplash neck injuries, uncomplicated by spinal fractures, luxations or by intracranial lesions, are described. BAM constitutes a subtype of posttraumatic migraine headaches, occurring in the absence of direct head trauma, and moderately and variably ameliorated with common anti‐migraine medications and physical therapy directed to the injured neck.
Defect of Serotonin Binding to Mononuclear Cells from Episodic Cluster Headache Patients
Authors: Martelletti P. , Alteri E. , Pesce A. , Rinaldi‐Garaci C. , Giacovazzo M. 
Published: June 2005

SYNOPSISMethysergide is the drug of choice for the prophylaxis of the crises in Episodic Cluster Headache (ECH). Thissubstance is a partial antagonist of both serotonin and histamine. Nevertheless, the classical anti‐histamine drugsdo not have any therapeutic effect in this disease. The etiological role of serotonin has never been taken intoconsideration, because the plasma levels of this mediator have never been found increased. This is not surprising,since serotonin is rapidly degraded in the circulation or immediately bound by circulating platelets. Therefore, apossible role of serotonin cannot be excluded. Serotonin is capable of modulating in vitro the motility of humanmonocytes. Our previous studies showed an increase in the number of circulating monocytes in ECH. Therefore,we examined the in vitro interactions between circulating cells from ECH patients and serotonin.21 ECH patients were studied, in and out of the crisis period. 5 adults were used as normal controls. Circulatingmononuclear cells were tested for their ability to specifically bind 5‐HT, using ( 3 H) labeled 5‐HT.Normal human mononuclear cells bind serotonin in a saturable and specific fashion, and most of this binding isthrough a high affinity site (Kd = 100nM). Conversely, cells from ECH patients lack this high affinity binding siteand only display binding through the low affinity site. The lack of this high affinity binding can be demonstrated inthe patients during the crisis as well as out of it.A possible explanation for the loss of this high affinity binding site could be that the cells of the patients havebeen previously exposed in vivo to high concentrations of serotonin, probably generated during the crisis period.
Scalp Tenderness and Sensitivity to Pain in Migraine and Tension Headache
Authors: Drummond Peter D. , Drummond Peter D. 
Published: June 2005

SYNOPSISPressure‐pain threshold was assessed in the forehead, temples, occiput and neck of 102 patients with migraine or tension headache, and in 35 nonheadache control subjects of similar age and sex distribution. Pain sensitivity to the application of a weighted blade to the fingers was also assessed. Tenderness was greater in patients than in controls, particularly at the site of migraine or tension headache, and to a lesser extent in other areas of the scalp. Scalp tenderness persisted for several days after headache had subsided. The threshold for pain in the fingers was greater during headache than during the headache‐free interval but did not differ from pain threshold in control subjects. Pain in the fingers increased more rapidly in patients with episodically‐recurring tension headaches than in other patient categories or control subjects. These findings demonstrate that scalp tenderness is not due to a general increase in sensitivity to pain during migraine. In contrast, diffuse disruption of central pain modulating systems may be involved in the pathophysiology of episodically‐recurring tension headaches.
Benign Recurrent Transient Monocular Blindness: A Possible Variant of Acephalgic Migraine
Authors: Tomsak Robert L. , Jergens Paul B. 
Published: June 2005

SYNOPSISTwenty‐four patients with benign recurrent transient monocular blindness of possible migrainous etiology are presented. The visual loss was predominantly one‐sided and stereotyped in character. Postural change or exercise was a provocative factor in half the cases. Other neurologic symptoms were not present and only one patient developed permanent visual loss during an attack. Evaluation by CT scanning, angiography, echocardiography, and ophthalmodynamometry, when performed, was uniformly normal.
Timolol Maleate, A Beta Blocker, In the Treatment of Common Migraine Headache
Authors: Gallagher R. Michael , Stagliano Robert A. , Sporazza Carl 
Published: June 2005

SYNOPSISTimolol maleate, a beta blocker, has been shown to reduce the frequency of common migraine headache in clinical trials. An analysis of 116 patients treated prophylactically for common migraine with timolol maleate 10–30 mg. per day was conducted. There were 35 males and 81 females ranging in age from 19 to 61 years; they experienced 3 to 8 headaches per month. After 6 months 11 patients (9%) showed > 75% improvement, 47 patients (41%) showed 50–74% improvement, 31 patients (27%) showed 25–49% improvement, 23 patients (20%) showed <25% improvement, and 4 patients (3%) discontinued because of side effects. This limited study suggests that timolol maleate may be of benefit in the treatment of some migraine patients.
Geomagnetic Activity and the Severity of the Migraine Attack
Authors: Kuritzky A. , Zoldan Y. , Hering R. , Stoupel E. 
Published: June 2005

SYNOPSISThirty patients suffering from either classical or common migraine recorded the dates of their headaches and their severity. A total of 486 attacks in fourteen months were recorded. Daily Geomagnetic activity (GMA) was obtained and graded to four levels of activity. No correlation was found between the frequency of the migraine attacks and the degree of GMA. The severity of the headache however was linearly correlated with the level of GMA, increasing from 25.9% of severe headaches in days with quiet GMA to 43.75% of severe headaches in days with stormy GMA.