bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demonstration and scale‐up of high‐temperature electrolysis systems
Authors: Schwarze Konstantin , Geißler Thomas , Nimtz Michael , Blumentritt Robert 
Published: October 2023

AbstractHigh‐temperature electrolysis (HTE) is a key to link the electricity sector with other industries and to evolve the electricity transition into a full energy transition. After years of development, HTE is now on the threshold to reach market readiness. The present work shows the latest achievements of Sunfire's development based on the results of the project GrInHy2.0 demonstrating hydrogen production (solid oxide electrolysis cell [SOEC]) in an industrial environment and the project SynLink demonstrating co‐electrolysis (Co‐SOEC) for renewable synthesis gas production. The GrInHy2.0 system is a 720 kWAC electrolyzer operating in the iron‐and‐steel works Salzgitter (Germany). It is now in operation for approx. 14,500 h and achieved a mean degradation rate below 23 mOhm cm2 kh−1 and an electrical efficiency of up to 84%LHV. It also proved that HTE now reached industrial‐relevant availability of over 90%. While the HTE system in Salzgitter consists of eight modules, a single module was tested in co‐electrolysis mode within the project SynLink. It demonstrated synthesis gas generation via Co‐SOEC with a flexible H2/CO ratio between 1 and 4. The work provides insight into how HTE will play a major role in the near future to efficiently produce renewable feedstock for an economy with a drastically reduced carbon footprint.
The association between periodontal disease and risk of adverse maternal or neonatal outcomes: A systematic review and meta‐analysis of analytical observational studies
Authors: Karimi Newsha , Samiee Negin , Moradi Yousef 
Published: October 2023

AbstractBackground and AimThe aim of this meta‐analysis was to find the association between periodontal disease (PD) and the risk of adverse pregnancy outcomes, including Pre‐eclampsia (PE), premature rupture of the amniotic sac, gestational diabetes (GDM), or low birth weight (LBW) in pregnant women, which should be investigated in a systematic meta‐analysis.MethodsStudies that reported the association between PD and pregnancy or neonatal outcomes and were published from January 1990 to December 2022, were identified by an extensive search in PubMed (Medline), Scopus, Web of Sciences, and Medline (Elsevier). After retrieving the studies, the screening stage was performed based on their titles, abstracts, and full texts, and after selecting the final articles, their information was extracted and their quality was assessed using the Newcastle Ottawa Scale checklist.ResultsPregnant women with PD had a 1.39 higher chance of developing GDM than those who did not have the infection (risk ratio [RR]: 1.39; 95% confidence interval [CI]: 1.21−1.61; I square: 49.67%; p: 0.03). Additionally, the pooled RR of LBW was 2.19, which indicates that pregnant women with PD had a 2.19‐fold higher risk of LBW than pregnant women who do not have the infection (RR: 2.19; 95% CI: 1.82−2.64; I square: 0.00%; p: 0.65). The relationship between the risk of PE and the existence of PD was examined in 33 cohort and case‐control studies for this meta‐analysis. These results were combined, and the pooled RR was 1.43. This indicates that pregnant women with PD are 1.43 times more likely to experience PE than pregnant women without PD (RR: 1.43; 95% CI: 1.32−1.54; I square: 82.64%; p: 0.00).ConclusionAccording to the findings of the current meta‐analysis, PD may contribute to a higher risk of poor maternal and newborn outcomes in pregnant women.
Ghanaian clients' perception of fitness instructors' adherence to exercise delivery services codes of conduct: An exploratory study
Authors: Tiguridaane Isaac A. , Doku Abigail O. , Deku Prince D.‐G. , Afrifa Daniel , Akwa Lady G. , Asamoah‐Mensah Anthony , Moses Monday O. 
Published: October 2023

AbstractBackground and AimsPatronage for fitness and wellness activities has increased in Ghana, but the perception of primary consumers regarding exercise delivery service codes of conduct (EDCC) remains undocumented. This study reported the perception of clients about fitness instructors' adherence to EDCC.MethodsThree hundred and seventy‐nine (mean age = 26.12 ± 8.83 years) clients registered with National Sports for ALL Association, Ghana (NASFAAG) were recruited. The participants were not living with any diagnosed disability, using psychiatric medication, and had consistently participated in fitness training, at least three times a week for a year, and not below the age of 18 years. The participants were recruited from fitness and wellness centers, gyms, and fitness clubs in three regions (Greater Accra—GA, Upper East—UE, and Ashanti—A) of Ghana. A closed‐ended, self‐structured and validated awareness and adherence exercise delivery codes of conduct questionnaires was administered. The questionnaire focused on data protection and responsibility, informed consent, competence, and professional and personal conduct adapted from the British Association of Sports and Exercise Science codes of conduct was administered. Statistical Package for Social Sciences (SPSS) version 23.0 was used to run factor analysis which determined factorial distribution of clients' perception of instructors on codes of conduct.ResultsIn total, 50.99% (UE), 47.68% (A), and 46.02% (GA) clients indicated that identities were unprotected when trainers displayed information. In all, 31.05% (UE), 40.34% (A), and 36.48% (GA) showed they were introduced to substances without consent. In total, 38.89% (UE), 32.70% (A), and 53.55% (GA) clients participated in training to realize that the expertise expected was not provided. In all, 38.10% (UE) and 36.23% (A) agreed that instructors put safety at risk, while 23.02% (GA) exploited clients for personal gain.ConclusionFitness instructors need enlightenment to adhere ethically to EDCC activities in Ghana. Activities related to wellness and fitness in Ghana require regulations.
Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial
Authors: Pazyar Nader , Raeispour Maryam , Yaghoobi Reza , Seyedtabib Maryam 
Published: October 2023

AbstractBackground and AimsMelasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic acid (TXA) into the deeper layers of the skin. Therefore, this study aimed to compare the effectiveness of microneedling with TXA with microneedling and vitamin C in treating melasma.MethodsIn patients with melasma, microneedling was performed at 2–3 mm depth. During that, TXA and vitamin C were poured on the skin of each side of the face, and then each ampoule was soaked for 15 min. This method was performed three times in 2‐week intervals, and the results were compared by measuring the Melasma Area and Severity Index (MASI) score before, during, and 2 months after the completion of the treatment.ResultsThe average MASI score in the baseline in the TXA group was 4.61, and in the vitamin C group was 4.58. The average MASI score in the patients treated with TXA in the last treatment session was 2.40, and the group treated with vitamin C was 2.44. The study results showed that the treatment was effective in both groups based on MASI score. Although there was a difference between the responses of the two groups, it was not significant.ConclusionMicroneedling with vitamin C and TXA is a safe and effective treatment option without side effects for treating melasma.
Investigation of a synonymous mutation in Btk in a patient with agammaglobulinemia: A case report
Authors: Srinivasan Cindy , Shameli Afshin , Ritchie Bruce , Adatia Adil 
Published: October 2023

AbstractBackgroundX‐linked agammaglobulinemia (XLA) is the most common form of agammaglobulinemia and is caused by mutations in Btk, which encodes Bruton tyrosine kinase (BTK).Case DescriptionWe describe a 36‐year‐old male who presented as an infant with hypogammaglobulinemia and sinopulmonary infections and was initially diagnosed with common variable immunodeficiency. Genetic testing showed he was hemizygous for Btk c.240G > A. This synonymous variant affecting the last nucleotide of exon 3 leads to aberrant splicing of most but not all mRNA transcripts.ConclusionWe demonstrated reduced BTK protein expression confirming the pathogenicity of the variant and related our findings to genotype‐phenotype relationship studies ina XLA caused by synonymous mutations.
Human papillomavirus and p16INK4a in oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis
Authors: Lu Yong , Clifford Gary M. , Fairley Christopher K. , Grulich Andrew E. , Garland Suzanne M. , Xiao Fei , Wang Yuan , Zou Huachun 
Published: October 2023

AbstractWe intended to update human papillomavirus (HPV) prevalence and p16INK4a positivity in oropharyngeal squamous cell carcinomars (SCC), and calculate HPV attributable fraction (AF) for oropharyngeal SCC by geographic region. We searched Medline, Embase, and the Cochrane Library to identify published studies of HPV prevalence and p16INK4a positivity alone or together in oropharyngeal SCC before December 28, 2021. Studies that reported type‐specific HPV DNA prevalence using broad‐spectrum PCR‐based testing methods were included. We estimated pooled HPV prevalence, type‐specific HPV prevalence, and p16INK4a positivity. AF of HPV was calculated by geographic region. One hundred and thirty‐four studies including 12 139 cases were included in our analysis. The pooled HPV prevalence estimate for oropharyngeal SCC was 48.1% (95% confidence interval [CI] 43.2‐53.0). HPV prevalence varied significantly by geographic region, and the highest HPV prevalence in oropharyngeal SCC was noted in North America (72.6%, 95% CI 63.8‐80.6). Among HPV positive cases, HPV 16 was the most common type with a prevalence of 40.2% (95% CI 35.7‐44.7). The pooled p16INK4a positivity in HPV positive and HPV16 positive oropharyngeal SCC cases was 87.2% (95% CI 81.6‐91.2) and 91.7% (84.3‐97.2). The highest AFs of HPV and HPV16 were noted in North America at 69.6% (95% CI 53.0‐91.5) and 63.0% (48.0‐82.7). [Correction added on 31 October 2023, after first online publication: the percentage symbol (%) was missing and has been added to 63.0% (48.0‐82.7) in the Abstract and Conclusion.] A significant proportion of oropharyngeal SCC was attributable to HPV. HPV16 accounts for the majority of HPV positive oropharyngeal SCC cases. These findings highlight the importance of HPV vaccination in the prevention of a substantial proportion of oropharyngeal SCC cases.
Voluntariness, timing, and consistency in adolescent routine disclosure and lying to parents
Authors: Smetana Judith G. , Li Yuejiao , Mncwabe Sduduzo 
Published: October 2023

AbstractIntroductionWhether adolescents' routine disclosure to parents is voluntary is assumed but rarely assessed. Researchers also have not examined whether disclosure and lying are premeditated, occurring before rather than after disclosure or lying, and whether adolescents use a single strategy consistently rather than applying multiple strategies when deciding whether to disclose or lie about their activities. This study investigated these significant gaps in the literature and tested whether voluntariness (for disclosure), timing, consistency, and parental psychological control are associated with lessons learned from disclosure and lying.MethodsNarrative interviews were conducted in 2014–2015 with 131 primarily middle‐class, mostly White US early and middle adolescents and college students (M's = 12.74, 15.81, 20.41 years). Narrated disclosure and lying interviews were reliably coded for voluntariness, timing, consistency, and lessons learned. Parental psychological control was assessed using an online survey.ResultsDisclosure was primarily strategic or voluntary and less often involuntary. Lying occurred more often before the narrated event, whereas disclosure occurred more often after. Youth typically reported using other strategies besides the elicited one. Disclosing after was associated with lessons learned. Voluntary disclosure was associated with psychological growth, and psychological control was associated with negative self‐lessons.ConclusionsDisclosure and lying are complex and nuanced, varying in their timing, consistency, and voluntariness. These features contribute to adolescents' meaning‐make from disclosure and lying. The findings have implications for future research on disclosure and secrecy.
The development of magnesium‐based biomaterials in bone tissue engineering: A review
Authors: Wu Jiaxin , Cheng Xinting , Wu Jicenyuan , Chen Junyu , Pei Xibo 
Published: October 2023

AbstractBone regeneration is a vital clinical challenge in massive or complicated bone defects. Recently, bone tissue engineering has come to the fore to meet the demand for bone repair with various innovative materials. However, the reported materials usually cannot satisfy the requirements, such as ideal mechanical and osteogenic properties, as well as biocompatibility at the same time. Mg‐based biomaterials have considerable potential in bone tissue engineering owing to their excellent mechanical strength and biosafety. Moreover, the biocompatibility and osteogenic activity of Mg‐based biomaterials have been the research focuses in recent years. The main limitation faced in the applications of Mg‐based biomaterials is rapid degradation, which can produce excessive Mg2+ and hydrogen, affecting the healing of the bone defect. In order to overcome the limitations, researchers have explored several ways to improve the properties of Mg‐based biomaterials, including alloying, surface modification with coatings, and synthesizing other composite materials to control the degradation rate upon implantation. This article reviewed the osteogenic mechanism and requirement for appropriate degradation rate and focused on current progress in the biomedical use of Mg‐based biomaterials to inspire more clinical applications of Mg in bone regeneration in the future.
Generation of fluorescent minibodies for rapid FLISA‐based detection of pine wilt disease marker
Authors: Kim Seon‐Hyung , Jeong Hee‐Jin 
Published: October 2023

AbstractBACKGROUNDDevelopment of a rapid and accurate detection method for a pine wilt disease (PWD) biomarker is crucial to prevent the spread of this disease in forests. In this study, we produced a recombinant minibody‐type antibody against Bursaphelenchus xylophilus peroxiredoxin (BxPrx), which is a protein secreted by the PWD‐causing B. xylophilus pathogen.ResultsWe labeled the anti‐BxPrx minibody using two different fluorescent dyes, Alexa Fluor (AF) 488 and AF647, and established a fluorescence‐linked immunosorbent assay (FLISA) system using these probes. Both fluorescent minibodies showed limit of detection values of 10.2 and 14.6 ng for the AF488‐ and AF647‐labeled antibodies, respectively, suggesting the usefulness of these probes for FLISA‐based sensitive detection of BxPrx.ConclusionThe entire duration for performing FLISA was 3 h, and enzyme‐conjugated secondary antibody incubation, washing and enzymatic reaction steps were not required, which was comparable to traditional ELISA. Both AF488‐ and AF647‐labeled minibodies showed high sensitivity, suggesting that these probes are useful for various fluorescence measurement techniques, which typically use green or red filters. © 2023 Society of Chemical Industry (SCI).
Prevalence and genotype distribution of human papillomavirus in cervical adenocarcinoma (usual type and variants): A systematic review and meta‐analysis
Authors: Reynders Celia , Lerho Thomas , Goebel Emily A. , Crum Christopher P. , Vandenput Sandrina , Beaudart Charlotte , Herfs Michael 
Published: October 2023

AbstractCervical glandular neoplasms represent a heterogeneous group of tumors for which a comprehensive overview of the involvement of high‐risk human papillomaviruses (HPV) in pathogenesis is still lacking. We first searched MEDLINE (PubMed), Embase, and Scopus databases (until October 2022), and systematically reviewed available literature. We then quantitatively estimated both pooled and genotype‐specific prevalence of HPV DNA as well as the influence of various factors (e.g., geographical region, histological subtype, tissue/sample type) on computed effect size by means of random effects meta‐analysis. In total, 379 studies comprising 17 129 cases of cervical adenocarcinoma were identified. The pooled HPV prevalence was 78.4% (95% confidence interval [95% CI]: 76.2–80.3) with a significant between‐study heterogeneity (I2 = 79.4%, Q test p < 0.0001). Subgroup analyses indicated that the effect size differed substantially by geographical region (from 72.5% [95% CI: 68.7–76.1] in Asia to 86.8% [95% CI: 82.2–90.3] in Oceania) (p < 0.0001) and histological subtype of cancer (from 9.8% [95% CI: 5.5–17] in gastric‐type to 85% [95% CI: 79.6–89.2] in usual‐type cervical adenocarcinoma) (p < 0.0001). HPV16 and HPV18 were by far the most frequently detected viral strains with specific prevalence of 49.8% (95% CI: 46.9–52.6) and 45.3% (95% CI: 42.8–47.8), respectively. When stratified by continent or histologic variant, these genotype‐specific results varied in a relatively limited manner. Altogether, these findings support that all histological subtypes of cervical adenocarcinoma are etiologically linked to high‐risk HPV but to varying degrees. Therefore, a dual‐criteria classification taking into account accurately both morphological and virological aspects could be an interesting evolution of the current binary World Health Organization classification, better reflecting the pathogenic diversity of the disease.
Profession choice processes and career counseling experiences of people with physical disabilities in Turkey
Authors: Avcı Özlem Haskan 
Published: October 2023

AbstractPeople with disabilities may face various barriers to employment. I aimed to explore the career counseling experiences of a sample of people with physical disabilities. The participants were 95 individuals with a disability aged 19–48 years. One emerging theme, barriers and aids, was related to family, teachers, and school counselors. Participants’ choices seemed to be affected by the negative attitudes of their peers with a disability. A second theme, career counseling as well as its availability, content, and quality, comprises subthemes such as collaboration between stakeholders in processes related to people with disabilities, qualifications of career counselors, and content of the services provided.
Fast neural network for TV super resolution scaling‐up system
Authors: Hsia Shih‐Chang , Wang Szu‐Hong , Yuan Wei‐Chien 
Published: October 2023

AbstractIn this paper, we propose a modified architecture aimed at reducing the computational demands of the generative adversarial network for super‐resolution image generation. To achieve this, we embedded depth‐wise and point‐wise convolution into the convolution layer, effectively decreasing operational complexity and improving the overall network structure. For training and validation, we utilized a dataset consisting of 900 image pairs with resolutions of 480 × 270 and 1920 × 1080. Our experimental results demonstrated that the proposed method can reduce computational operators by 63% compared to the original network, while still maintaining the quality of super‐resolution images. To enable real‐time implementation, the architecture with light model subsequently deployed it on a GPU processor, allowing for efficient scaling of TV signals for 16× resolution expansion. Our experiments showed that the peak signal‐to‐noise ratio (PSNR) reached approximately 28 dB, and the processing rate ranged from 6 to 14 frames per second. The network effectively produced output with 16 times greater resolution without introducing any blurring and obvious artifact.
Clinically meaningful change threshold in health‐related quality of life among patients aged 6 months to 5 years with atopic dermatitis and their caregiver(s)/family
Authors: Paller Amy S. , Marron Servando E. , Whalley Diane , Nelson Lauren , Qin Shanshan , Chao Jingdong , Bansal Ashish , Chuang Chien‐Chia , Wang Zhixiao 
Published: October 2023

AbstractBackgroundAtopic dermatitis (AD) significantly impacts health‐related quality of life (HRQoL) in children and their caregiver(s)/family. Measures to assess HRQoL include the Children's Dermatology Life Quality Index (CDLQI), Infants' Dermatitis Quality of Life Index (IDQoL) and Dermatitis Family Impact (DFI) questionnaire. Currently, there are no established clinically meaningful within‐person change thresholds for these measures in young children (6 months to 5 years) and their caregiver(s)/family.ObjectivesTo determine the clinically meaningful within‐person change thresholds for CDLQI (4–5 years), IDQoL (<4 years) and DFI scores in children aged 6 months to 5 years with moderate‐to‐severe AD and their caregiver(s)/family.MethodsData from the 16‐week, randomised, double‐blind, placebo‐controlled, phase 3 LIBERTY AD PRESCHOOL part B study in children aged 6 months to 5 years were used. The anchor‐based method was used to assess meaningful change thresholds for the three instruments, using the Caregiver Global Impression of Disease (CGID; range: ‘no symptoms’ to ‘very severe’) as the primary anchor, and Caregiver Global Impression of Change (CGIC; range: ‘much better’ to ‘much worse’) as a supportive anchor.ResultsThe mean CDLQI change scores were −6.3 and −9.5 based on CGID 1‐point improvement and CGIC improvement of ‘a little better’, respectively. The mean IDQoL change scores were −5.6 and −3.4 based on the CGID and CGIC anchors. The mean DFI change scores were −7.0 and −6.7 based on the CGID and CGIC anchors.ConclusionsBased on primary anchor findings, improvements of ≥6 points on the CDLQI total score for children aged 4–5 years and on the IDQoL total score for children aged <4 years were recommended as the clinically meaningful within‐person change thresholds in children with moderate‐to‐severe AD. A 7‐point improvement on the DFI total score may be considered as the meaningful threshold for the caregiver(s)/family of children aged 6 months to 5 years with moderate‐to‐severe AD.
Harnessing the value of procurement knowledge and practices for firm performance: A resource orchestration perspective
Authors: Acquah Innocent Senyo Kwasi , Opoku Agyemang Faustina , Baah Charles , Afum Ebenezer , Agyabeng‐Mensah Yaw 
Published: October 2023

AbstractAlthough the role of procurement knowledge and practices in securing a competitive advantage for firms cannot be over‐emphasised, the literature lacks empirical evidence in this regard. Accordingly, this study examines the effects of procurement knowledge and practices on firm performance as well as how procurement practices mediate the nexus between procurement knowledge and firm performance. Partial least squares structural equation modelling results based on survey data of 150 procurement and supply chain professionals suggest that procurement planning, supplier partnership, contract management and compliance increase firm performance. Also, a positive relationship was established between procurement knowledge and all procurement practices investigated. Furthermore, apart from procurement planning, the remaining procurement practices fully mediated the effect of procurement knowledge on firm performance. Findings provide relevant implications for theory and practice.