bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the selenium level with GSH‐Px activity in the liver of mice treated with 7,12 DMBA
Authors: Batcioglu Kadir , Ozturk Cetin , Karagozler Alev , Karatas Fikret 
Published: August 2002

AbstractIn this study, the relationship between selenium (Se) and glutathione peroxidase (GSHPx) levels was investigated in 7,12‐dimethylbenz(a)anthracene (7,12‐DMBA)‐treated mouse liver. The potential mammary carcinogen 7,12‐DMBA, was injected intraperitoneally (20 mg kg−1 day−1) into 10–12 month old female mice. After 21 days of application the mice were sacrificed and GSHPx and Se levels of liver homogenates were measured. Se and GSHPx levels in 7,12‐DMBA‐treated mice were significantly lower than those of controls (p < 0.05). The control group exhibited 0.9 ± 0.066 U mg−1 protein and 0.86 ± 0.058 p.p.m. levels of GSHPx and Se respectively. The 7,12‐DMBA‐treated group had significantly (p < 0.05) decreased GSHPx and Se levels (0.42 ± 0.062 U mg−1 protein and 0.69 ± 0.034 p.p.m. respectively). The results show a direct relationship between Se and GSHPx activity and a negative correlation between antioxidant capacity and existence of a carcinogen in metabolism. Copyright © 2001 John Wiley & Sons, Ltd.
Age‐related decline in postextrasystolic potentiation in patients with aortic stenosis
Authors: D'Agate David J. , Snyder Craig A. , Marzo Kevin P. , Lazar Jason M. 
Published: August 2002

AbstractIn aortic stenosis (AS), postextrasystolic potentiation (PESP), a measure of contractile reserve, has been demonstrated by an increased aortic valve gradient (AVG) after a ventricular extrasystole (VE). We studied age‐related changes in PESP in 20 consecutive patients (age, 65–89 years) with significant AS (aortic area ≤ 1.0 cm2) on cardiac catheterization with VE on AVG pressure recording. Hemodynamics and LV systolic time intervals were averaged from three consecutive beats and from the post‐VE beat. Changes (Δ) in AVG, pre‐ejection period/LV ejection time ratio (PEP/LVET), aortic diastolic pressures (AoDP), and LV end‐diastolic pressures (LVEDP) were calculated. Age was inversely correlated with ΔAVG (r = −0.84, P = 0.0001), with ΔPEP/LVET (r = −0.87, P = 0.0001), and with ΔAoDP (r = −0.89, P = 0.0001), but not with ΔLVEDP (r = 0.23, P = 0.31). On multivariate analysis, only age was associated with ΔAVG (r2 = 0.72, P = 0.0001). There was an age‐related decline in PESP in patients with AS, which was accompanied by changes in contractile reserve and afterload reduction, but independent of preload reserve. Cathet Cardiovasc Intervent 2002;55:23–27. © 2002 Wiley‐Liss, Inc.
Catheter therapy of Swiss cheese ventricular septal defects using the Amplatzer muscular VSD occluder
Authors: Waight David J. , Bacha Emile A. , Kahana Madelyn , Cao Qi‐Ling , Heitschmidt Mary , Hijazi Ziyad M. 
Published: August 2002

AbstractThe medical and surgical management of patients with multiple muscular ventricular septal defects (VSDs) is associated with morbidity and mortality. Three children with Swiss cheese VSDs were treated with transcatheter occlusion of their multiple defects using the Amplatzer muscular VSD occluder. Seventeen defects were closed in five catheterization procedures. One patient had three devices placed in two procedures, the second had five defects closed in one procedure, and the third had nine defects closed in two procedures. Two patients had previously been treated with pulmonary artery banding and required subsequent surgical band removal. There was immediate reduction in the left‐to‐right shunting and clinical improvement in all patients. Complications included the need for blood transfusion during the two longest procedures and tricuspid valve regurgitation in one. Transcatheter occlusion of multiple VSDs is an acceptable alternative or adjunct to surgical therapy for these complex patients. Cathet Cardiovasc Intervent 2002;55:355–361. © 2002 Wiley‐Liss, Inc.
Left main crumpling during left anterior descending angioplasty: Hitherto unreported location for the “accordion effect”
Authors: Alvarez José A.G. , Leiva Gustavo , Manavella Bibiana , Cosentino J.J. Adolfo 
Published: August 2002

AbstractVessel wall shortening and deformity due to “arterial telescoping” is a not infrequent reversible phenomenon that occurs during coronary angioplasty and is associated with the advancement of a stiff wire through elongated and tortuous segments, with straightening of the artery and deep guiding catheter introduction beyond the coronary ostium. We present the first described case of the accordion effect involving the left main coronary artery. On detecting arterial crumpling, it is essential to make a differential diagnosis between the accordion syndrome and PTCA potential complications (spasm, thrombosis and dissection), to avoid further therapeutic intervention. Cathet Cardiovasc Intervent 2001;52:363–367. © 2001 Wiley‐Liss, Inc.
Agreement between coronary flow velocity reserve and stress echocardiography in intermediate‐severity coronary stenoses
Authors: Duffy Stephen J. , Gelman John S. , Peverill Roger E. , Greentree Michèle A. , Harper Richard W. , Meredith Ian T. 
Published: August 2002

AbstractVisual and quantitative assessments of percent diameter stenosis on coronary angiography correlate poorly with functional testing, particularly in intermediate‐severity (40%–70%) lesions, yet are frequently relied on to make decisions regarding revascularization. Coronary flow velocity reserve (CFVR) and relative CFVR (RCFVR) are promising methods for on‐line functional assessment of lesion severity in the catheterization laboratory. We sought to determine the agreement between maximal, mean, and relative CFVR and stress echocardiography in intermediate‐severity stenoses. The results of exercise or dobutamine stress echocardiography and CFVR measured by intracoronary Doppler were compared in 28 patients referred for assessment of intermediate‐severity stenoses, using 15 patients with either angiographically normal coronary arteries or diameter stenoses > 70% as reference groups. CFVR was measured at least three times in response to a bolus of adenosine in the target vessel distal to the stenosis. RCFVR (target/normal vessel CFVR) was also measured in 27 patients. Maximal, mean (of three measures), and relative CFVR were calculated. CFVR ≥ 2.0 and RCFVR ≥ 0.75 were accepted as normal. A minority (29%) of patients in the intermediate‐severity stenosis group had a positive test by either method. There was good to very good agreement between stress echocardiography and maximal CFVR (84%, κ = 0.62, P < 0.0001) and RCFVR (81%, κ = 0.59, P < 0.001) across the entire patient cohort, though in the intermediate subgroup concordance was only fair. Using the mean (of three measures of) CFVR for the same comparison improved the agreement in the intermediate subgroup to good (86%, κ = 0.58, P = 0.002), and in the entire cohort the agreement was very good (88%, κ = 0.74, P < 0.0001). There was only fair correlation between measures of CFVR and percent coronary stenosis. CFVR improved from 1.8 ± 0.8 to 2.7 ± 0.7 after percutaneous intervention (n = 12, P < 0.0001). These results suggest that there is good agreement between CFVR and stress echocardiography across a wide range of coronary lesion severity. The mean of three CFVR measurements distal to the target vessel stenosis increases diagnostic accuracy. Intracoronary Doppler flow velocity measurements at the time of cardiac catheterization may facilitate improved decision‐making by providing the ability to assess the functional significance of coronary stenoses on‐line. Cathet Cardiovasc Intervent 2001;53:29–38. © 2001 Wiley‐Liss, Inc.
Significance of balloon imprint during coronary angioplasty
Authors: Ilia Reuben , Cafri Carlos , Weinstein Jean Marc , Abu‐Ful Akram , Merkin Miri , Yaroslavtsev Sergei , Gilutz Harel , Appelbaum Azai 
Published: August 2002

AbstractBalloon imprint during angioplasty is often seen, but not at all inflations. We prospectively studied 235 consecutive patients undergoing 282 PTCAs during a 4‐month period, who were divided into two groups: those with balloon imprint during inflation (159 patients, 190 lesions; 67%) and those without (76 patients, 92 lesions; 33%). Clinical and lesion characteristics and immediate outcome were compared. Patients undergoing urgent PTCA had less balloon imprint than those undergoing nonurgent PTCA (14.2% vs. 28.3%; P < 0.005). Although not reaching statistical significance, younger patients and diabetic patients tended toward less balloon imprint (P < 0.06). Patients with observed imprint had less visible thrombus at lesion site (31.1% vs. 42.4%; P < 0.05), and a tendency without statistical significance toward more dissections but less acute closure was observed (P < 0.07). In addition, more stents were implanted in the imprint group (79.5% vs. 66.3%; P < 0.02). Patients needing pressure > 6 atm to break the imprint had more eccentric lesions (68% vs. 27.1%; P < 0.000) and more dissections (13.9% vs. 5.1%; P < 0.03) than those needing lower pressure. Patient and lesion characteristics may determine the appearance of balloon imprint at PTCA, which in turn influences the procedure and its immediate outcome. Cathet Cardiovasc Intervent 2001;53:331–333. © 2001 Wiley‐Liss, Inc.
Angiographic analysis of immediate and long‐term results of PTCR vs. PTCA in complex lesions (COBRA study)
Authors: Dietz Ulrich , Rupprecht Hans‐Juergen , Ekinci Okan , Dill Thorsten , Erbel Raimund , Kuck Karl‐Heinz , Abdollahnia Reza , Rippin Gerd , Meyer Juergen , Hamm Christian 
Published: August 2002

AbstractWe conducted a prospective, randomized trial to compare immediate and long‐term effects of percutaneous transluminal coronary angioplasty (PTCA) and high‐frequency rotational atherectomy (PTCR) in patients with angiographically predefined complex coronary artery lesions (AHA type B2 and C). The relation of lesion characteristics to procedural results is reported in this angiographic analysis. Patients were randomly assigned to balloon angioplasty (n = 250 patients) or rotational atherectomy (n = 252 patients). Quantitative coronary angiography could be performed in 447 patients to evaluate immediate results and in 293 patients with a 6‐month angiographic follow‐up. Procedural success was comparable in the PTCR and in the PTCA group (80% vs. 76%, P = 0.260). The need for stent implantation due to a residual stenosis >50% or a bail‐out situation was significantly higher in the PTCA group (9.7% vs. 2.0%, P = 0.001). In both treatment groups, diameter stenosis was effectively reduced and MLD increased. The acute gain did not differ between the two groups. At 6‐month control, the restenosis rate was comparable in the PTCR and in the PTCA group (37% vs. 35%, P = 0.658), whereas diameter stenosis was significantly more severe in the PTCR group than in the PTCA group (52% vs. 46%, P = 0.039) and, correspondingly, the MLD was significantly smaller in the PTCR group (1.29 mm vs. 1.44 mm, P = 0.031). Late loss was about the same in both groups, however, net gain and net gain index were significantly higher in the PTCA group (0.82 mm vs. 0.64 mm, P = 0.008; and 31% vs. 24%, P = 0.009). Analysis of procedural results for various lesion characteristics revealed no significant difference between treatment groups. In this randomized trial, complex coronary artery lesions were treated with comparable results for angiographic and procedural success and the restenosis rate by both, PTCA and PTCR. Late loss, however, was significantly higher and net gain significantly smaller after PTCR. Stents, although infrequently used, had a relevant impact on immediate PTCA results but not on late results. Cathet Cardiovasc Intervent 2001;53:359–367. © 2001 Wiley‐Liss, Inc.
Safety of magnetic resonance imaging immediately following Palmaz stent implant: A report of three cases
Authors: Rutledge Jennifer M. , Vick G. Wesley , Mullins Charles E. , Grifka Ronald G. 
Published: August 2002

AbstractMagnetic resonance imaging (MRI) can provide important information on patients with congenital heart defects. There is some reluctance to perform MRI acutely following intravascular stent implant, due to concerns of distortion or movement of the stent in the magnetic field. We report on three patients who underwent MRI evaluation less than 14 days following Palmaz stent implant in the pulmonary arteries and superior vena cava, with no acute adverse outcome or long‐term problems. Cathet Cardiovasc Intervent 2001;53:519–523. © 2001 Wiley‐Liss, Inc.
Incremental doses of intracoronary adenosine for the assessment of coronary velocity reserve for clinical decision making
Authors: Di Segni Elio , Higano Stuart T. , Rihal Charanjit S. , Holmes David R. , Lennon Ryan , Lerman Amir 
Published: August 2002

AbstractAchievement of maximal vasodilatation of the coronary microcirculation is a prerequisite for the measurement of coronary flow reserve (CFR). The present study was designed to address the hypothesis that intracoronary adenosine yields more complete vasodilation of the coronary microcirculation when incremental doses are used, resulting in higher and more accurate coronary flow reserve measurements. Four hundred and fifty‐seven patients were divided in two groups; group I (319 patients) comprised patients without angiographic evidence of significant coronary artery disease, while group II (138 patients) comprised patients with intermediate coronary stenoses (between 40% and 70% diameter stenosis). Coronary velocity reserve (CVR, a surrogate measurement for CFR) was measured during cardiac catheterization using a Doppler‐tipped guidewire. Incremental doses of intracoronary adenosine (12 to 54 μg for the left coronary artery and 6 to 42 μg for the right coronary artery) were administered. There was a significant difference between the initial dose of adenosine and the subsequent incremental doses. Of a total of 479 observations, only 192 (40%) had the maximal CVR value at the first dose. Thirty‐nine percent of the patients in group I and 27% in group II with an initial CVR value < 2.5 increased CVR to ≥ 2.5 with incremental doses of adenosine. This study suggests that incremental doses of adenosine should be used to achieve maximal CVR for the assessment of the functional significance of coronary lesions. Cathet Cardiovasc Intervent 2001;54:34–40. © 2001 Wiley‐Liss, Inc.
A randomized trial comparing the hand‐mounted JoStent with the premounted Multi‐Link Duet stent in patients with coronary artery disease
Authors: Mehilli Julinda , Kastrati Adnan , Dirschinger Josef , Dotzer Franz , Schühlen Helmut , Fleckenstein Martin , Neumann Franz‐Josef , Schömig Albert 
Published: August 2002

AbstractThe objective of this multicenter randomized study was to compare the angiographic and clinical results achieved 1 year after coronary placement of two stent models: the hand‐mounted JoStent and the premounted Multi‐Link Duet stent. We included 505 patients who were randomly assigned to receive either the hand‐mounted JoStent (n = 252) or the premounted Multi‐Link Duet stent (n = 253). The primary endpoint of the study, late lumen loss, measured 1.12 mm in the JoStent group and 1.17 mm in the Multi‐Link Duet group. These values were statistically equivalent (P = 0.02 from the equivalence test). No significant difference was observed in the incidence of restenosis, 24.2% in the JoStent and 25.2% in the Multi‐Link Duet stent group, and target vessel revascularization, 13.9% in the JoStent and 15.4% in the Multi‐Link Duet patients. In conclusion, the hand‐mounted JoStent and the premounted Multi‐Link Duet stent enable excellent procedural success rates and equally favorable 1‐year angiographic and clinical outcomes. Cathet Cardiovasc Intervent 2001;54:414–419. © 2001 Wiley‐Liss, Inc.
Recent applications of stereoselective chromatography
Authors: Szymura‐Oleksiak Joanna , Bojarski Jacek , Aboul‐Enein Hassan Y. 
Published: August 2002

AbstractSome recent applications of stereoselective chromatography in the fields of clinical pharmacy, drug analysis, food, and natural products are reviewed. The review is documented with up‐to‐date literature, which will assist further expansion of research in these areas. Chirality 14:417–435, 2002. © 2002 Wiley‐Liss, Inc.
Is (9Z)‐“meso”‐zeaxanthin optically active?
Authors: Lutnæs Bjart Frode , Gautun Odd Reidar , Liaaen‐Jensen Synnøve 
Published: August 2002

AbstractThe question raised in the title was answered. (3R, 3′S)‐meso‐Zeaxanthin was submitted to iodine catalyzed photochemical stereoisomerisation. The enantiomeric (9Z) and (9′Z) geometrical isomers were isolated by semipreparative HPLC and separated as diastereomeric dicarbamates on a chiral column only. Cleavage of the carbamate could not be effected. CD‐Spectra of (1″S, 1″S)‐ and (1″R, 1″R)‐dicarbamates of geometrical isomers of (3R, 3′R)‐ and (3R, 3′S)‐meso‐zeaxanthin were systematically studied and the contribution from the carbamate moieties revealed. It was concluded that (9Z, 3R, 3′S)‐“meso”‐zeaxanthin, in spite of having no symmetry elements, is optically inactive. The result has been rationalised in line with the current hypothesis on the origin of carotenoid CD spectra. Chirality 13:224–229, 2001. © 2001 Wiley‐Liss, Inc.
Induced circular dichroism in solid‐state inclusion compounds
Authors: Tanaka Koichi , Kato Masako , Toda Fumio 
Published: August 2002

AbstractIn order to measure the circular dichroism (CD) spectrum in the solid state of a chiral compound which has no chromophore, an induced CD spectral method was developed by measuring the spectrum of the inclusion crystal of the chiral compound with a simple achiral aromatic host compound in the Nujol mulls. Chirality 13:347–350, 2001. © 2001 Wiley‐Liss, Inc.
Quantitative analysis of the behavior of Dictyostelium discoideum amoebae: stringency of pteridine reception
Authors: Rifkin Jared L. 
Published: August 2002

AbstractA convenient, sensitive, quantitative assay for the measurement of chemotaxis of populations of D. discoideum vegetative amoebae is presented. A strategy for determining the boundary of the bulk of a population of migrating amoebae was devised and is described. This assay employs a dynamic gradient and is independent of deaminase activity. Measurements of chemoattractant capabilities of various pteridines, folates, and mixtures of folate fragments are reported. 2‐Amino 4‐quinazolinone, a pterin analog without the pyrazine ring nitrogens, is chemotactic. Lumazine, deaminated pterin, inhibits chemotaxis towards pterin but not towards folic acid. Deaminofolic acid is a chemoattractant as are mixtures of lumazine plus aminobenzoylglutamic acid or deaminopteroic acid plus various amino acids. Separately, the components of these mixtures exhibit no ability to stimulate chemotaxis. These mixtures are of fragments that together comprise most of the folate structure. Our results are in accord with separate receptors for pterin vs. folic acid and with a high stringency for pterin reception but a relative tolerance for folate reception. The possibility of using such mixtures to investigate the requirements of various parts of the folate structure for competent signalling is discussed. Cell Motil. Cytoskeleton 51:39–48, 2002. © 2002 Wiley‐Liss, Inc.
Axonemal activity relative to the 2D/3D‐waveform conversion of the flagellum
Authors: Cibert C. 
Published: August 2002

AbstractThe waveform of the flagellum of the sea urchin spermatozoon is mainly planar, but its 3D‐properties were evoked for dynamic reasons and described as helical. In 1975, the apparent twisting pattern of the sea urchin axoneme was described [Gibbons I. 1975. The molecular basis of flagellar motility in sea urchin spermatozoa. In: Inoué S, Stephens R, editors. Molecular and cellular movement. New York: Raven Press, p. 207–232.] and was considered to be one of the main elements involved in axonemal behaviour. Recently, planar, quasi‐planar, and helical waveforms were observed when the flagellum of sea urchin sperm cells was submitted to an increase in viscosity. The quasi‐planar conformation seemed to be due to the alternating torsion of the inter‐bend segments [Woolley D, Vernon G. 2001. A study of helical and planar waves on sea urchin sperm flagella, with a theory of how they are generated. J. Exp. Biol. 204:1333–1345]. These three waveforms, which are due to a change in axonemal activity, are possibly used by the sperm cells to adapt their movement to variations in the physico‐chemical characteristics of the medium (seawater) in which the cells normally swim. We constructed a simple model to describe qualitatively the central shear (between the axonemal doublets and the central pair) and the tangential shear (between the doublets themselves). In this model, the 3D‐bending is resolved into components in two perpendicular planes and each of the nine planes of inter‐doublet interaction defines a potential bending plane that is independently regulated. These shears were calculated for the three waveforms and their inter‐conversion. This allowed us to propose that axoneme is resolved in successive modules delineated by abscissas where the sliding is always nil. We discuss these data concerning the axonemal machinery, and especially the alternating activity of opposite sides of (two) neutral surface(s) that seem(s) to be responsible for this inter‐conversion, and for the possible twist of the axoneme during the beating. Cell Motil. Cytoskeleton 51:89–111, 2002. © 2002 Wiley‐Liss, Inc.
Differential expression and localization of neuronal intermediate filament proteins within newly developing neurites in dissociated cultures of Xenopus laevis embryonic spinal cord
Authors: Undamatla Jayanthi , Szaro Ben G. 
Published: August 2002

AbstractThe molecular subunit composition of neurofilaments (NFs) progressively changes during axon development. In developing Xenopus laevis spinal cord, peripherin emerges at the earliest stages of neurite outgrowth. NF‐M and XNIF (an α‐internexin‐like protein) appear later, as axons continue to elongate, and NF‐L is expressed after axons contact muscle. Because NFs are the most abundant component of the vertebrate axonal cytoskeleton, we must understand why these changes occur before we can fully comprehend how the cytoskeleton regulates axon growth and morphology. Knowing where these proteins are localized within developing neurites and how their expression changes with cell contact is essential for this understanding. Thus, we examined by immunofluorescence the expression and localization of these NF subunits within dissociated cultures of newly differentiating spinal cord neurons. In young neurites, peripherin was most abundant in distal neuritic segments, especially near branch points and extending into the central domain of the growth cone. In contrast, XNIF and NF‐M were usually either absent from very young neurites or exhibited a proximal to distal gradient of decreasing intensity. In older neurites, XNIF and NF‐M expression increased, whereas that of peripherin declined. All three of these proteins became more evenly distributed along the neurites, with some branches staining more intensely than others. At 24 h, NF‐L appeared, and in 48‐h cultures, its expression, along with that of NF‐M, was greater in neurites contacting muscle cells, arguing that the upregulation of these two subunits is dependent on contact with target cells. Moreover, this contact had no effect on XNIF or peripherin expression. Our findings are consistent with a model in which peripherin plays an important structural role in growth cones, XNIF and NF‐M help consolidate the intermediate filament cytoskeleton beginning in the proximal neurite, and increased levels of NF‐L and NF‐M help further solidify the cytoskeleton of axons that successfully reach their targets. Cell Motil. Cytoskeleton 49:16–32, 2001. © 2001 Wiley‐Liss, Inc.