bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overproduction of bacterial cellulose from Acetobacter xylinum BPR2001 using food industries wastes
Authors: Khanchezar Sirwan , Babaeipour Valiolah , Mostafa Atiyeh Sadat 
Published: January 2024

AbstractIn this study, a cost‐effective complex culture media containing molasses and corn steep liquor (CSL) was developed for the high production of bacterial cellulose (BC) by investigating the effect of four effective factors on BC production at three levels using Taguchi and combined methods. The predicted and actual values of BC production in optimal conditions by Taguchi and combined methods were 8.41 and 14.52 g/L, respectively. These results showed that the combined method was more suitable for predicting the optimal conditions in the optimization of BC production, the cost of developed culture medium was around 94% cost of HS medium preparation, molasses was the most effective factor in both experimental design methods, and initial pH adjustment had little impact on BC production. Then, the effect of inoculation conditions containing three factors of inoculation age, ethanol addition time, and agitation rate on the increase of BC production at three levels was investigated using the response surface methodology with the Box–Behnken design algorithm. Under the optimal conditions including inoculum age of 3 days, ethanol addition time of 10 days, and stirring speed of 100 rpm, the predicted and experimental results of BC production were 21.61 and 20.21 g/L, respectively. This is among the highest ever reported for BC production, which was achieved with a more cost‐effective culture medium containing molasses and CSL.
Lyceum and university aspirations among migrants and non‐migrants in Italy
Authors: Buonomo Alessio , Caputo Giustina Orientale , Gabrielli Giuseppe , Gargiulo Giuseppe 
Published: January 2024

AbstractScholars have argued that, on average, immigrant students are ‘optimists’ and have higher educational aspirations than non‐migrant students after accounting for students' socio‐economic background and educational performance. However, ethnic minority groups, which proxy the different origin backgrounds of migrants, may show mixed findings in terms of educational aspirations. This study aims to analyse the lyceum (the most theoretical school in Italy) and university aspirations of migrant‐origin students and their Italian counterparts, enrolled respectively in Italian lower (Grade 8: age 13) and upper secondary state schools (Grades 9–11: ages 14–16). The analyses are based on data from the Italian Integration of the Second Generation survey conducted during the 2014/15 school year. Our results show that students having Chinese, Moroccan, Moldovan and other non‐European Union Eastern European origins assume the lowest levels of lyceum aspiration after also considering compositional effects. Conversely, the largest proportion of migrants attending school in Grades 9–11 have higher levels of university aspiration compared to non‐migrants. When considering the role of migratory generation, lyceum and university aspirations are positively associated with the acculturation process of migrants. Furthermore, we found that high family expectations, social relationships and self‐perception benefits of studying have positive associations with both lyceum and university aspirations, especially among migrants.
Liquid chromatography–tandem mass spectrometry determination of bumetanide in human plasma and application to a clinical pharmacokinetic study
Authors: Tamilarasi Ganesan Padmini , Manikandan Krishnan , Solomon Viswas Raja 
Published: January 2024

AbstractDetermining a drug's bioavailability and bioequivalence is important for developing and approving a drug product. The procedure supports applications for generic drug products and novel therapeutic substances, makes important decisions regarding safety and efficacy, and measures a drug's concentration in biological matrices. This study aimed to develop and validate a specific, simple, sensitive, and accurate method using liquid chromatography–tandem mass spectrometry (LC–MS) for measuring bumetanide (BUM) in human plasma. Chromatographic separation was achieved using a Hypurity C18 column (4.6 × 50 mm, 5 μm) under isocratic conditions, and LC–MS detected positive ionization acquisition modes. Protonated precursor to product ion transitions were observed at m/z 365.08 → 240.10 and 370.04 → 244.52 for BUM and internal standard, respectively. The linear range of BUM in plasma samples was 3.490–401.192 ng/mL. The inter‐precision value ranged from 1.76% to 4.75%. The inter‐accuracy value ranged from 96.46% to 99.95%. The method was adequately validated per the U.S. Food and Drug Administration guidelines, and the results were within permissible bounds. The Cmax and Tmax values were ~53.097 ± 13.537 ng/mL and 1.25 (0.67–5.00) h, respectively. The new approach showed satisfactory results for studying BUM in human plasma with potential use in pharmacokinetic and bioequivalence investigations.
Natural polyphenolic coffee extract administration relieves chronic nociplastic pain in a reserpine‐induced fibromyalgia‐like female mouse model
Authors: Toledano‐Martos Rubén , Bagó‐Mas Anna , Deulofeu Meritxell , Homs Judit , Fiol Núria , Verdú Enrique , Boadas‐Vaello Pere 
Published: January 2024

AbstractIntroductionNociplastic pain involves reflexive and nonreflexive pain responses and it is a core symptom of fibromyalgia (FM). The increasing prevalence of this health condition and the low rates of patients’ quality of life, combined with the lack of suitable pharmacologic treatments, evidence the demand to research new alternatives. Polyphenols may be potential therapeutic candidates as they have been reported to exert pathological pain modulation in preclinical models. In that context, this work was aimed to study the antinociceptive effects of a polyphenolic extract obtained from decaffeinated ground roasted coffee, in the RIM6 FM‐like mouse model.MethodsTo this end, RIM6 adult ICR‐CD1 female mice were administered daily once a week with either 10 or 15 mg/kg of extract, and reflexive pain responses were evaluated for up to 3 weeks. At the end, the depressive‐like behavior was assessed as a nonreflexive pain response, and spinal cord and serum samples were collected for immunohistochemical and toxicological analyses.ResultsThese findings showed that the repeated administration of the coffee polyphenolic extract (CE) modulated reflexive pain responses, depressive‐like behavior, and spinal cord gliosis in a dose‐dependent manner, without signs of systemic toxicity.ConclusionThus, the CE may be a potential pharmacological treatment suitable to relieve nociplastic pain responses characteristic of FM.
Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort
Authors: Christakoudi Sofia , Tsilidis Konstantinos K. , Evangelou Evangelos , Riboli Elio 
Published: January 2024

AbstractBackgroundObesity and diabetes are associated inversely with low‐grade prostate cancer risk and affect steroid hormone synthesis but whether they modify each other's impact on prostate cancer risk remains unknown.MethodsWe examined the independent associations of diabetes, body mass index (BMI), ‘a body shape index’ (ABSI), hip index (HI), circulating testosterone, sex hormone binding globulin (SHBG) (per one standard deviation increase) and oestradiol ≥175 pmol/L with total prostate cancer risk using multivariable Cox proportional hazards models for UK Biobank men. We evaluated multiplicative interactions (pMI) and additive interactions (relative excess risk from interaction (pRERI), attributable proportion (pAR), synergy index (pSI)) with obese (BMI ≥30 kg/m2) and diabetes.ResultsDuring a mean follow‐up of 10.3 years, 9417 incident prostate cancers were diagnosed in 195,813 men. Diabetes and BMI were associated more strongly inversely with prostate cancer risk when occurring together (pMI = 0.0003, pRERI = 0.032, pAP = 0.020, pSI = 0.002). ABSI was associated positively in obese men (HR = 1.081; 95% CI = 1.030–1.135) and men with diabetes (HR = 1.114; 95% CI = 1.021–1.216). The inverse associations with obesity and diabetes were attenuated for high‐ABSI ≥79.8 (pMI = 0.022, pRERI = 0.008, pAP = 0.005, pSI <0.0001 obesity; pMI = 0.017, pRERI = 0.047, pAP = 0.025, pSI = 0.0005 diabetes). HI was associated inversely in men overall (HR = 0.967; 95% CI = 0.947–0.988). Free testosterone (FT) was associated most strongly positively in normal weight men (HR = 1.098; 95% CI = 1.045–1.153) and men with diabetes (HR = 1.189; 95% CI = 1.081–1.308). Oestradiol was associated inversely in obese men (HR = 0.805; 95% CI = 0.682–0.951). The inverse association with obesity was stronger for high‐FT ≥243 pmol/L (pRERI = 0.040, pAP = 0.031, pSI = 0.002) and high‐oestradiol (pRERI = 0.030, pAP = 0.012, pSI <0.0001). The inverse association with diabetes was attenuated for high‐FT (pMI = 0.008, pRERI = 0.015, pAP = 0.009, pSI = 0.0006). SHBG was associated inversely in men overall (HR = 0.918; 95% CI = 0.895–0.941), more strongly for high‐HI ≥49.1 (pMI = 0.024).ConclusionsObesity and diabetes showed synergistic inverse associations with prostate cancer risk, likely involving testosterone reduction for diabetes and oestrogen generation for obesity, which were attenuated for high‐ABSI. HI and SHBG showed synergistic inverse associations with prostate cancer risk.
Molybdenum Sulfide Nanomaterial: A Potential Candidate for Separation Membranes
Authors: Jatoi Ashique Hussain , Soomro Faheeda , Maqbool Imran , Iqbal Muzaffar , Chandio Weenghar Ali , Memon Ayaz Ali , Thebo Khalid Hussain 
Published: January 2024

AbstractMolybdenum sulfide (MoS2)‐based nanocomposites have attracted significant attention for various separation processes due to their ultrathin thickness, high mechanical and chemical strength, and good functionality. Herein, the recent progresses of various fabrication, synthesis, and modification methods for separation membrane‐based on MoS2 nanocomposites are reviewed. Emphasis is given on applications of MoS2‐based membranes in the purification of wastewater, separation of gas mixtures, energy storage separator, and proton‐exchange fuel cells (PEFCs). Advantages and drawbacks of this material for separation applications are discussed. Finally, a future roadmap is suggested for this promising nanomaterial in various separation processes.
A Critical Analysis on Transformation of Renewable Energy to Green Chemicals: Opportunities and Challenges
Authors: Rashid Muhammad Imran , Benhelal Emad , Abbas Muhammad Mujtaba 
Published: January 2024

AbstractThe abundant natural resources and rapidly falling prices to generate and store renewable energy create a remarkable opportunity for a new group of manufacturing industries to emerge. These technology pathways use abundant or waste resources to produce green chemicals and fuels like green hydrogen (H2), green ammonia (NH3), and green synthetic hydrocarbons (HCs). Integrating chemical processes and renewable energy can complete the carbon loop and bring substantial decarbonization along with economic opportunities around the globe. An evidence‐based and industry‐focused critical review of technologies to produce green chemicals and fuels from renewable energy is presented. It also discusses the market size and applications for these emerging industries and presents their development status, benefits, and challenges to commercialization. Green hydrogen production from renewable energy turns out to be the initial and key stage for all these technological advancements and is indispensable for their techno‐economic viability. Other environmentally friendly feedstocks, such as nitrogen (from the air) and wastes such as CO2 (from industrial flue gas), can produce green chemicals. Besides environmental benefits, several other benefits of producing green chemicals from renewable energy are identified. These include but are not limited to (i) accelerating the economy for renewable energy and hydrogen generation, (ii) savings in energy, costs, and natural resources, and (iii) creating millions of jobs. A perspective on opportunities to develop the green chemical industry and assist academia, industry, and policymakers is provided.
Ethylene Glycol‐Containing Acrylic Polyphosphazene Based Cathode Materials via Inverse Vulcanization of Sulfur for Li−S Batteries
Authors: Yeşilot Serkan , Küçükköylü Sedat , Mutlu Tutku , Demir‐Cakan Rezan 
Published: January 2024

AbstractThe cell performance of Li−S batteries can be improved by establishing compatibility with the electrolyte of cathode and enhancing lithium‐ion diffusion (ionic conductivity) or electrical conductivity. In this work, we introduce cathode material based on ethylene glycol‐containing acrylic polyphosphazene. Poly[(2acrylamidoethoxy)‐random‐(methoxyethoxyethoxy)] phosphazenes were synthesized by macromolecular substitution of poly(dichloro)phosphazene with 2‐acrylamidoethanol and diethylene glycol methyl ether in two different ratios (25 and 50 mol% of ethylene glycol methyl ether), abbreviated as MP‐25EG and MP‐50EG, where ethylene glycol chains enhance the electrolyte compatibility and ion transport of the sulfur cathode material. Then, poly[S‐random‐(2acrylamidoethoxy)‐random‐(methoxyethoxyethoxy)] phosphazene polymers, designated as MP‐25EG‐xS or MP‐50EG‐xS (x=50 and 80 wt.% of sulfur) were prepared by inverse vulcanization of polymer with two feed sulfur ratios. Structural characterizations of the polymers were carried out using appropriate standard spectroscopic methods such as 1H and 31P NMR, FT‐IR, DSC and TGA as well as XPS. The electrochemical performance of MP‐25EG‐50S, MP‐25EG‐80S and MP‐50EG‐50S, MP‐50EG‐80S were evaluated and the effect of ethylene glycol was investigated by comparing cell performances. MP‐50EG‐50S demonstrated its promising applicability in Li–S batteries by exhibiting much better electrochemical respond with a discharge capacity of 745 mAh/g at C/5 current density over 100 cycles.
Gallaphosphene L(Cl)GaPGaL: A novel phosphinidene transfer reagent
Authors: Sharma Mahendra K. , Weinert Hanns M. , Wölper Christoph , Schulz Stephan 
Published: January 2024

AbstractGallaphosphene L(Cl)GaPGaL 1 (L=HC[C(Me)N(Ar)]2; Ar=2,6‐iPr2C6H3) reacts with N‐heterocyclic carbenes RNHC (RNHC=[CMeN(R)]2C; R=Me, iPr) to RNHC‐coordinated phosphinidenes RNHC→PGa(Cl)L (R=Me 2 a, iPr 2 b) and with isonitriles RNC (R=iPr, Cy) to 1,3‐phosphaazaallenes L(Cl)GaP=C=N−R (R=iPr 3 a, Cy 3 b), respectively. Quantum chemical calculations reveal that 2 a/2 b possess two localized lone pair of electrons, whereas 3 a/3 b only show one localized lone pair as was reported for gallaphosphene 1. 2 b reacts with 2.5 equivalents of a borane (THF ⋅ BH3) to the NHC‐stabilized phosphinidene‐borane complex [iPrNHC→P(BH2)]2(BH3)3 4 with concomitant formation of LGa(H)Cl 5. 2–5 are characterized by heteronuclear (1H, 13C{1H}, 31P{1H}) NMR and IR spectroscopy, elemental analysis, and single crystal X‐ray diffraction (sc‐XRD).
Suppressed pediatric asthma hospitalizations during the COVID‐19 pandemic in Japan, from a national survey
Authors: Korematsu Seigo , Fujisawa Takao , Saito Naruo , Tezuka Junichiro , Miura Katsushi , Kobayashi Ichiro , Miyata Ippei , Kosugi Yujiro , Gohda Yuji , Koike Yumi , Suda Ami , Matsuo Akiko , Sasaki Michiyo , Handa Yousuke , Fujiwara Michimasa , Ono Atsushi , Koizumi Shinya , Oishi Taku , Tanaka Takayuki , Ando Yusuke , Taba Naohiko , Tsurinaga Yuki , Sato Takeshi , Kanai Rei , Yashiro Masato , Takagi Toshiyuki , Hida Shinya , Harazaki Masashi , Hoshina Takayuki , Okada Seigo , Yasutomi Motoko , Nakata Setsuko , Muto Ayako , Tanabe Saori , Ueda Yutaka , Hasegawa Shunji , Kameda Makoto , Tanaka‐Taya Keiko , Fujimoto Tsuguto , Okada Kenji 
Published: January 2024

AbstractBackgroundAcute asthma exacerbation in children is often caused by respiratory infections. In this study, a coordinated national surveillance system for acute asthma hospitalizations and causative respiratory infections was established. We herein report recent trends in pediatric acute asthma hospitalizations since the COVID‐19 pandemic in Japan.MethodsThirty‐three sentinel hospitals in Japan registered all of their hospitalized pediatric asthma patients and their causal pathogens. The changes in acute asthma hospitalization in children before and after the onset of the COVID‐19 pandemic and whether or not COVID‐19 caused acute asthma exacerbation were investigated.ResultsFrom fiscal years 2010–2019, the median number of acute asthma hospitalizations per year was 3524 (2462–4570), but in fiscal years 2020, 2021, and 2022, the numbers were 820, 1,001, and 1,026, respectively (the fiscal year in Japan is April to March). This decrease was observed in all age groups with the exception of the 3‐ to 6‐year group. SARS‐CoV‐2 was evaluated in 2094 patients from fiscal years 2020–2022, but the first positive case was not detected until February 2022. Since then, only 36 of them have been identified with SARS‐CoV‐2, none of which required mechanical ventilation. Influenza, RS virus, and human metapneumovirus infections also decreased in FY 2020. In contrast, 24% of patients had not been receiving long‐term control medications before admission despite the severity of bronchial asthma.ConclusionSARS‐CoV‐2 was hardly detected in children with acute asthma hospitalization during the COVID‐19 pandemic. This result indicated that SARS‐CoV‐2 did not induce acute asthma exacerbation in children. Rather, infection control measures implemented against the pandemic may have consequently reduced other respiratory virus infections and thus acute asthma hospitalizations during this period. However, the fact that many hospitalized patients have not been receiving appropriate long‐term control medications is a major problem that should be addressed.
Rational design and virtual screening identify mimetics of the RXR agonist valerenic acid
Authors: Isigkeit Laura , Kärcher Annette , Adouvi Gustave , Arifi Silvia , Merk Daniel 
Published: January 2024

AbstractThe ligand‐sensing transcription factor retinoid X receptor (RXR) is the universal heterodimer partner of nuclear receptors and involved in multiple physiological processes. Its pharmacological modulation holds therapeutic potential in cancer and neurodegeneration but many available RXR ligands lack specificity. The sesquiterpenoid valerenic acid has been identified as RXR agonist with unprecedented subtype and homodimer preference. Here, we identified simplified mimetics of the complex natural product by rational design and virtual screening that exhibited similar activity profiles on RXR and informed about structural elements contributing to the favorable activity.
Adjuvant platinum versus capecitabine for residual, invasive, triple‐negative breast cancer: Patient‐reported outcomes in ECOG‐ACRIN EA1131
Authors: Smith Karen L. , Zhao Fengmin , Mayer Ingrid A. , Tevaarwerk Amye J. , Garcia Sofia F. , Arteaga Carlos L. , Symmans William F. , Park Ben H. , Burnette Brian L. , Makower Della F. , Block Margaret , Morley Kimberly A. , Jani Chirag R. , Mescher Craig , Dewani Shabana J. , Brown‐Glaberman Ursa , Flaum Lisa E. , Mayer Erica L. , Sikov William M. , Rodler Eve T. , DeMichele Angela M. , Sparano Joseph A. , Wolff Antonio C. , Miller Kathy D. , Wagner Lynne I. 
Published: January 2024

AbstractBackgroundPatient‐reported outcomes (PROs) are a better tool for evaluating the experiences of patients who have symptomatic, treatment‐associated adverse events (AEs) compared with clinician‐rated AEs. The authors present PROs assessing health‐related quality of life (HRQoL) and treatment‐related neurotoxicity for adjuvant capecitabine versus platinum on the Eastern Cooperative Oncology Group‐American College of Radiology Imaging Network (ECOG‐ACRIN) EA1131 trial (ClinicalTrials.gov identifier NCT02445391).MethodsParticipants completed the National Comprehensive Cancer Network Functional Assessment of Cancer Therapy–Breast Cancer Symptom Index (NFBSI‐16) and the Functional Assessment of Cancer Therapy–Gynecologic Oncology Group neurotoxicity subscale (platinum arm only) at baseline, cycle 3 day 1 (C3D1), 6 months, and 15 months. Because of early termination, power was insufficient to test the hypothesis that HRQoL, as assessed by the NFBSI‐16 treatment side‐effect (TSE) subscale, would be better at 6 and 15 months in the capecitabine arm; all analyses were exploratory. Means were compared by using t‐tests or the Wilcoxon rank‐sum test, and proportions were compared by using the χ2 test.ResultsTwo hundred ninety‐six of 330 eligible patients provided PROs. The mean NFBSI‐16 TSE subscale score was lower for the platinum arm at baseline (p = .02; absolute difference, 0.6 points) and for the capecitabine arm at C3D1 (p = .04; absolute difference, 0.5 points), but it did not differ at other times. The mean change in TSE subscale scores differed between the arms from baseline to C3D1 (platinum arm, 0.15; capecitabine arm, −0.72; p = .03), but not from baseline to later time points. The mean decline in Functional Assessment of Cancer Therapy–Gynecologic Oncology Group neurotoxicity subscale scores exceeded the minimal meaningful change (1.38 points) from baseline to each subsequent time point (all p < .05).ConclusionsDespite the similar frequency of clinician‐rated AEs, PROs identified greater on‐treatment symptom burden with capecitabine and complemented clinician‐rated AEs by characterizing patients’ experiences during chemotherapy.
An LSTM‐based novel near‐real‐time multiclass network intrusion detection system for complex cloud environments
Authors: Vibhute Amol D. , Khan Minhaj , Kanade Anuradha , Patil Chandrashekhar H. , Gaikwad Sandeep V. , Patel Kanubhai K. , Saini Jatinderkumar R. 
Published: January 2024

SummaryThe Internet is connected with everyone for sharing and monitoring digital information. However, securing network resources from malicious activities is critical for several applications. Numerous studies have recently used deep learning‐based models in detecting intrusions and received relatively robust recognition outcomes. Nevertheless, most investigations have operated old datasets, so they could not detect the most delinquent attack information. Therefore, the current research proposes the long short‐term memory (LSTM)‐based near real‐time multiclass network intrusion detection system (NIDS) utilizing complex cloud CSE‐CICIDSS2018 datasets to secure and detect the network anomalous. The proposed strategy utilizes a random forest algorithm for dimensionality reduction and feature selection. In addition, the selected best suitable features were used in a deep learning‐based LSTM model developed for detecting network intrusions. The experimental outcomes reveal that the presented LSTM model obtained 99.66% testing accuracy with 0.12% loss. Thus, the suggested approach can detect network intrusions with the highest precision and lowest rate over the earlier designs.