bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of ocular rinse volume on surface irritation after povidone-iodine preparation for intravitreal injections: a randomized controlled trial
Authors: Jamshidi Farzad , Jin Haoxing D. , Bruce Andrew , Kutteh Michael , Ding Kai , Riaz Kamran M. , Kingsley Ronald M. , Shah Vinay A. 
Published: September 2023

Abstract
Purpose
To evaluate whether the volume of wash out rinse after povidone iodine (PI) application for intravitreal injections (IVI) affects patients’ ocular surface irritation.

Methods
This was a prospective, single-masked, randomized-controlled trial consisting of 142 subjects. A total of 51, 45, and 46 patients received 3-mL, 10-mL, and 15-mL of ocular rinse respectively. Reductions in the Ocular Surface Disease Index (OSDI) and the Standardized Patient Evaluation of Eye Dryness II (SPEED II) surveys, conducted before and at 24–72 h post-injection, were analyzed.

Results
There was no statistical difference in objective dry eye findings of Schirmer test (p-value = 0.788), tear break-up time (p-value = 0.403), Oxford fluorescein grade (p-value = 0.424) between the study groups prior to injections. Dry eye symptoms as measured by reductions in the OSDI and SPEEDII scores were not different between the study groups (p-value = 0.0690 and 0.6227, respectively).

Conclusion
There is no difference in patients’ ocular surface irritation between 3-mL, 10-mL, and 15-mL post injection rinse. Given the large number of IVIs performed, modification of practice patterns based on these findings could lead to significant reduction in global cost burden for IVIs.
[18F]Fluorocholine PET/CT false positive: foreign body reaction mimicking anaplastic glioma progression. A case report
Authors: Rudolphi-Solero Teodoro , Triviño-Ibáñez Eva María , Martínez-Barbero José Pablo , Cordero-Tous Nicolás , Chamorro-Santos Clara Eugenia , Rodríguez-Fernández Antonio , Gómez-Río Manuel María 
Published: September 2023

Abstract
Background
Foreign body reaction in brain tissue is a very rare immune response that has not been well studied. Hemostatic material has been reported as a possible trigger of this response in other organs and could be detected by [18F]fluorodeoxyglucose positron emission tomography/computerized tomography ([18F]FDG PET/CT), but there is no reported experience about the role of [18F]fluorocholine in this finding. [18F]Fluorocholine has the potential to differentiate viable central nervous system tumors from other entities, so it is frequently used in the follow-up of neurosurgery patients.

Case presentation
A right frontoparietal neoplastic lesion was found in a young-aged patient with analgesic refractory headache. Surgical resection and postsurgical radiotherapy were performed, and the pathologist analysis turned out a cellular ependymoma with signs of anaplasia. In the follow-up, an magnetic resonance imaging (MRI) showed a suspicious lesion, so a [18F]fluorocholine PET/CT was performed. Increased uptake was described in the right parietal region on the margin of the residual cystic lesion. The patient got a complete resection which was confirmed later by MRI. In the pathology analysis, a focally congestive cerebral parenchyma with a central histiocytic reaction to a foreign body area was described.

Conclusions
Following the experience of the current case report, [18F]fluorocholine PET/CT could also show a false positive related to foreign body reaction. This entity should be considered to avoid unnecessary major surgery on our patients.
Immune-mediated hematological disease in dogs is associated with alterations of the fecal microbiota: a pilot study
Authors: Liu P.-Y. , Xia D. , McGonigle K. , Carroll A. B. , Chiango J. , Scavello H. , Martins R. , Mehta S. , Krespan E. , Lunde E. , LeVine D. , Fellman C. L. , Goggs R. , Beiting D. P. , Garden O. A. 
Published: September 2023

Abstract
Background
The dog is the most popular companion animal and is a valuable large animal model for several human diseases. Canine immune-mediated hematological diseases, including immune-mediated hemolytic anemia (IMHA) and immune thrombocytopenia (ITP), share many features in common with autoimmune hematological diseases of humans. The gut microbiome has been linked to systemic illness, but few studies have evaluated its association with immune-mediated hematological disease. To address this knowledge gap, 16S rRNA gene sequencing was used to profile the fecal microbiota of dogs with spontaneous IMHA and ITP at presentation and following successful treatment. In total, 21 affected and 13 healthy control dogs were included in the study.

Results
IMHA/ITP is associated with remodeling of fecal microbiota, marked by decreased relative abundance of the spirochete Treponema spp., increased relative abundance of the pathobionts Clostridium septicum and Escherichia coli, and increased overall microbial diversity. Logistic regression analysis demonstrated that Treponema spp. were associated with decreased risk of IMHA/ITP (odds ratio [OR] 0.24–0.34), while Ruminococcaceae UCG-009 and Christensenellaceae R-7 group were associated with increased risk of disease (OR = 6.84 [95% CI 2–32.74] and 8.36 [95% CI 1.85–71.88] respectively).

Conclusions
This study demonstrates an association of immune-mediated hematological diseases in dogs with fecal dysbiosis, and points to specific bacterial genera as biomarkers of disease. Microbes identified as positive or negative risk factors for IMHA/ITP represent an area for future research as potential targets for new diagnostic assays and/or therapeutic applications.
Mismatch between school furniture dimensions and anthropometric parameters is a risk for spinal deformities in secondary school students in Lagos, Nigeria: a cross-sectional study
Authors: Aiyegbusi Ayoola Ibifubara , Gbiri Caleb Ademola , Oyeniran Tolulope Olaoluwa , Balogun Oluwaseyi Jessy 
Published: September 2023

Abstract
Background
A mismatch between school furniture dimensions and anthropometric parameters has been well documented in adolescents, but there is a paucity of data on the impact of these mismatches on the students’ spinal health in Nigeria. This study therefore investigated the relationship of spinal deformities with selected anthropometric parameters and furniture dimensions of adolescents in secondary schools.

Methods
This study involved 540 apparently healthy students between the ages of 10 and 19 years from 9 public and private secondary schools in Lagos state, Nigeria. The furniture dimensions, anthropometric parameters, and spinal curvature disorders were evaluated using standard protocol. Data was analyzed using SPSS version 20.0 with a level of significance set at p < 0.05.

Results
Two hundred two (37%) of the participants had abnormal spinal curvatures in varying types and degrees. There was a significant association at p ≤ 0.05 between the presence of spinal deformities and popliteal height to seat height mismatch (X2 = 175.67, p = 0.001), hip breadth to seat width mismatch (X2 = 293.14, p = 0.00), and shoulder height to backrest height mismatch (X2 = 788.16, p = 0.001).

Conclusion
Anthropometric parameters to furniture dimensions mismatch are significantly associated with the presence of spinal deformities among the students. The main cause of mismatch is using a homogeneous size of furniture for all students in addition to non-consideration of the students’ dimensions during furniture manufacturing.
Water in Fullerenes
Authors: Hashikawa Yoshifumi , Murata Yasujiro 
Published: September 2023

Abstract
A water molecule fixed within [60]fullerene is the simplest form of water available in meatspace. It was first artificially made by us in 2011. Since then, anomalies of water molecules free from any hydrogen-bonding have been discovered in succession. In this account, we summarize the research progress in the past decade from the aspect of synthesis, derivatization, and reactivity of fullerenes with water inside as well as their quantum and classical dynamics.
Influence of geomagnetic disturbances on scintillations of GLONASS and GPS signals as observed on the Kola Peninsula
Authors: Belahovskiy Vladimir , Budnikov Pavel , Kalishin Alexey , Pilgaev Sergey , Roldugin Alexey 
Published: September 2023

We have compared effects of geomagnetic disturbances during magnetic storms of various types (CME and CIR) and during an isolated substorm on scintillations of GLONASS and GPS signals, using a Septentrio PolaRx5 receiver installed in Apatity (Murmansk Region, Russia). We analyze observational data for 2021. The magnetic storms of November 3–4, 2021 and October 11–12, 2021 are examined in detail. The November 3–4, 2021 magnetic storm was one of the most powerful in recent years. The analysis shows that the scintillation phase index reaches its highest values during nighttime and evening substorms (σϕ≈1.5–1.8), accompanied by a negative bay in the magnetic field. During magnetic storms, positive bays in the magnetic field, associated with an increase in the eastward electrojet, lead, however, to quite comparable values of the phase scintillation index.
An increase in phase scintillations during nighttime and evening disturbances correlates with an increase in the intensity of ULF waves (Pi3/Pc5 pulsations) and with the appearance of aurora arcs. This confirms the important role of ULF waves in forming the auroral arc and in developing ionospheric irregularities. The predominance of the green line in the spectrum of auroras indicates the contribution of disturbances in the ionospheric E layer to the scintillation increase. Pulsating auroras, associated with ionospheric disturbances in the D layer, do not lead to a noticeable increase in phase scintillations. Analysis of ionospheric critical frequencies according to ionosonde data from the Lovozero Hydrometeorological Station indicates the contribution of the sporadic Es layer of the ionosphere to jumps in phase scintillations.
The difference between phase scintillation values on GLONASS and GPS satellites during individual disturbances can be as great as 1.5 times, which may be due to different orbits of the satellites. At the same time, the level of GLONASS/GPS scintillations at the L2 frequency is higher than at the L1 frequency. We did not find an increase in the amplitude index of scintillations during the events considered.
On the Hardness of Learning from Censored and Nonstationary Demand
Authors: Lugosi Gábor , Markakis Mihalis G. , Neu Gergely 
Published: September 2023

We consider a repeated newsvendor problem in which the inventory manager has no prior information about the demand and can access only censored/sales data. In analogy to multiarmed bandit problems, the manager needs to simultaneously “explore” and “exploit” with inventory decisions in order to minimize the cumulative cost. Our goal is to understand the hardness of the problem disentangled from any probabilistic assumptions on the demand sequence—importantly, independence or time stationarity—and, correspondingly, to develop policies that perform well with respect to the regret criterion. We design a cost estimator that is tailored to the special structure of the censoring problem, and we show that, if coupled with the classic exponentially weighted forecaster, it achieves optimal scaling of the expected regret (up to logarithmic factors) with respect to both the number of time periods and available actions. This result also leads to two important insights: the benefit from “information stalking” as well as the cost of censoring are both negligible, at least in terms of the regret. We demonstrate the flexibility of our technique by combining it with the fixed share forecaster to provide strong guarantees in terms of tracking regret, a powerful notion of regret that uses a large class of time-varying action sequences as benchmark. Numerical experiments suggest that the resulting policy outperforms existing policies (that are tailored to or facilitated by time stationarity) on nonstationary demand models with time-varying noise, trend, and seasonality components. Finally, we consider the “combinatorial” version of the repeated newsvendor problem, that is, single-warehouse, multiretailer inventory management of a perishable product. We extend the proposed approach so that, again, it achieves near-optimal performance in terms of the regret. Funding: G. Lugosi was supported by the Spanish Ministry of Economy, Industry and Competitiveness [Grant MTM2015-67304-P (AEI/FEDER, UE)]. M. G. Markakis was supported by the Spanish Ministry of Economy and Competitiveness [Grant ECO2016-75905-R (AEI/FEDER, UE)] and a Juan de la Cierva fellowship as well as the Spanish Ministry of Science and Innovation through a Ramón y Cajal fellowship. G. Neu was supported by the UPFellows Fellowship (Marie Curie COFUND program) [Grant 600387]. Supplemental Material: The e-companion is available at https://doi.org/10.1287/ijoo.2022.0017 .
The added value of devices to pelvic floor muscle training in radical post-prostatectomy stress urinary incontinence: A systematic review with metanalysis
Authors: Benedetto Giardulli , Simone Battista , Gaia Leuzzi , Mirko Job , Ottavia Buccarella , Marco Testa 
Published: September 2023

Purpose
To investigate the role of pelvic floor devices (e.g., biofeedback, electrical stimulation, magnetic stimulation, or their combination) as adjunctive treatments in pelvic floor muscle training (PFMT) in stress urinary incontinence (SUI) after radical prostatectomy.

Materials and methods
A systematic review with meta-analysis. We searched for randomised controlled trials (RCTs) and prospective non-randomised studies investigating the effectiveness of pelvic floor devices as an adjunctive treatment for SUI symptoms assessed with weight pad-test or standardised questionnaires. To assess the risk of bias (RoB) and overall certainty of evidence, the RoB 2.0 or the ROBINS-I, and the GRADE approach were used.

Results
Eleven RCTs met our eligibility criteria. One was at a ‘low’ RoB, one had ‘some concerns’, while nine were at a ‘high’ RoB. Two meta-analyses were conducted to analyse the pooled results of six RCTs included. Specifically, two RCTs reported at week 4 with a 1h pad test a mean difference of 0.64 (95% CI = [-13.09, 14.36]), and four RCTs reported at week 12 with a 24h pad test a mean difference of -47.75 (95% CI = [-104.18, 8.69]). The heterogeneity was high in both analyses (I2 = 80.0%; I2 = 80.6%). The overall level of certainty was very low.

Conclusions
In line with our results, we cannot conclude whether pelvic floor devices add any value as adjunctive treatment in the management of SUI after radical prostatectomy. Future studies require more comprehensive and standardised approaches to understand whether these devices are effective.
Role of community pharmacists in cardiovascular diseases-related health promotion and dyslipidemia management in Malaysia: A nationwide cross-sectional study
Authors: Ismail Farhana Fakhira , Md Redzuan Adyani , Chong Wei Wen , Ahmad Nizaruddin Mariani 
Published: September 2023

Background
Cardiovascular disease (CVD) is a leading cause of death and disability worldwide, imposing a significant burden on patients and healthcare systems. The role of pharmacists in reducing cardiovascular disease (CVD) is pivotal as they play an essential part in the healthcare team, particularly in medication management and patient education. Pharmacists are well-positioned to contribute to the prevention and control of CVD through various roles, including medication management and patient education. This study aims to investigate the current involvement of community pharmacists in Malaysia, specifically in cardiovascular diseases-related health promotion activities and dyslipidemia management, including their perceived barriers.

Method
This cross-sectional survey was conducted among community pharmacists in all 14 states of Malaysia between November 2021 and July 2022. The self-administered survey was shared to relevant groups through various social media platforms.

Results
A total of 312 community pharmacists were involved in the survey. Majority of the respondents were females (66%), with a mean age (SD) of 32.9 (8.4) years. Most of the respondents showed satisfactory practice for patient counselling, but improvements are needed particularly in risk assessment and collaborative care aspect. Most of them expressed their interest for dyslipidemia management training (89.4%). Lack of access to medical records (71.2%) and lack of CVD-related educational materials (70.8%) were the two main perceived barriers identified.

Conclusion
Community pharmacists in Malaysia provide a satisfactory role in the provision of cardiovascular disease-related health promotion activities, especially in providing patient counselling. Strengthening collaborative care is essential for providing comprehensive and patient-centered intervention in dyslipidemia management. This requires ongoing efforts to address and overcome existing barriers for effective teamwork and coordination among healthcare professionals.
Uncovering English as a foreign language teacher resilience: a structural equation modeling approach
Authors: Liu Honggang , Chu Wenxiu 
Published: September 2023

Abstract
While teacher resilience has gained wide currency in the general education field, empirical research on language teacher resilience is still insufficient, especially with regard to the exploration of its inner structure. Against this backdrop, this study utilized a quantitative approach to investigate the structure of English as a foreign language (EFL) teacher resilience. An adapted Chinese version of the Multidimensional Teachers’ Resilience Scale (MTRS) was completed by 539 Chinese junior high school EFL teachers. Exploratory and confirmatory factor analyses provided an acceptable fit for the 13-item MTRS and identified a tri-factorial structure of teacher resilience concerning professional competence, sociability, and grit. Based on these findings, the paper offers some implications for developing studies on language teacher resilience in the future.
Evaluation on the method of restoring the complex communication environment in the field based on the complex low pressure platform simulation platform
Authors: Jiang Jianfeng , Zhu Wenjun 
Published: September 2023

Abstract
In recent years, with the development of smart grids, people have increasingly high requirements for the safety, stability, and reliability of smart grid operation. In actual operation, smart grids require real-time monitoring and control, while for low-voltage power lines, power line carrier communication is required for data transmission. However, in practical applications on site, the low-voltage power line environment is complex, with ground faults, electrical equipment interference, and other situations that can affect communication quality and reliability, leading to a decrease in the effectiveness of real-time monitoring and control. The research in this paper is based on a complex low voltage platform simulation platform to restore the on-site complex substation communication environment. The purpose is to improve the efficiency of automatic meter reading systems by using various communication methods in low-voltage substations, such as wireless public network point-to-point data transmission, optical fiber communication data transmission, power line carrier data transmission, etc. Automatic meter reading systems are an important means of low voltage substation communication. This article experimentally tested the maximum personnel allocation for meter reading using low voltage carrier communication technology, which was 8 people smaller than the maximum personnel allocation for traditional meter reading, and the minimum personnel allocation was 8 people smaller than the traditional meter reading personnel allocation. The electricity accuracy of meter reading using low voltage carrier communication was up to 96 %, while the electricity accuracy of traditional meter reading was 70 %. The maximum accuracy of line loss statistics for low voltage carrier communication technology meter reading was 90 %, while the maximum accuracy of line loss statistics for traditional meter reading was 68 %. The frequency of load anomalies found in low-voltage carrier communication meter readings within a month ranged from 30 to 60 times, while the traditional meter readings concentrated on 10–25 times. From these data, it is clear that communication meter reading in low-voltage station areas has advantages over traditional meter reading.
A Note on Canon and Hermeneutics: Junillus, Inst. 1.1-10
Authors: Toom Tarmo 
Published: September 2023

Abstract
For interpreting Scripture, one needs to figure out what exactly is to be interpreted when the Word of God is interpreted. Because canon and hermeneutics are so tightly connected, several early Christian introductions to Scripture (introductiones) provided lists of canonical books. This article assesses a little-known canonical list provided by a sixth-century treatise Instituta regularia divinae legis by Junillus. His aim was to show the particular ways the biblical books in various genres communicated their message as the canonical Scripture. Junillus’ Instituta is a Latin version of the lost work of Paul the Persian, who was educated in Syria, at the School of Nisibis. As such, Instituta is a unique and original example of a broadly Antiochean exegetical tradition, which is disseminated for western readers. Cassiodorus recommended it to his students at Vivarium.
Clinical heterogeneity and therapeutic options for idiopathic infantile hypercalcemia caused by CYP24A1 pathogenic variant
Authors: Zheng Zhichao , Wu Yujie , Wu Huiping , Jin Jiahui , Luo Yue , Cao Shunshun , Shan Xiaoou 
Published: September 2023

Abstract

Objectives
Infantile hypercalcemia-1 (HCINF1) is a rare disease caused by pathogenic variants in the CYP24A1 gene, resulting in the inability to metabolize active vitamin D. This leads to hypercalcemia and severe complications.

Content
On December 8th, 2022, a systematic literature search was conducted in PubMed, Wanfang, and CNKI using the keywords “hypercalcemia” and “CYP24A1”. Data extraction included patient demographics, clinical presentation, treatment medications, and outcomes. The findings were synthesized to identify common patterns and variations among cases and to assess the efficacy of different therapies in reducing serum calcium. Our findings revealed two distinct peaks in the incidence of HCINF1 caused by CYP24A1 pathogenic variant. Kidney stones or renal calcifications were the most common clinical manifestations of the disease, followed by polyuria and developmental delay. Laboratory investigations showed hypercalcemia, elevated vitamin D levels, hypercalciuria, and low parathyroid hormone. Genetic analysis remains the only reliable diagnostic tool. Although there is no definitive cure for HCINF1, multiple drugs, including bisphosphonates, calcitonin, and rifampicin, have been used to control its symptoms. Blocking the production and intake of vitamin D is the preferred treatment option.

Summary and outlook
Our review highlights the basic clinical and biochemical features of HCINF1 and suggests that targeted diagnostic and therapeutic strategies are needed to address the clinical heterogeneity of the disease. The insights gained from this study may facilitate the development of innovative treatments for HCINF1.