bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENYULUHAN PACKAGING DAN LABELLING PRODUK OLAHAN NANAS PADA UMKM DAN KELOMPOK WANITA TANI DESA SRI KEMBANG 1 KECAMATAN PAYARAMAN KABUPATEN OGAN ILIR
Authors: Ningrum Puri Pratami Ardina , Batubara Mustopa Marli , Afriyatna Sisvaberti , Fahmi Innike Abdilah , Iskandar Sutarmo , Apriani Novi , Maulana Yusuf 
Published: January 2025

Penyuluhan merupakan kegiatan yang dilakukan untuk memberikan informasi ataupun mendidik suatu kelompok agar mendapatkan ilmu yang lebih bernilai, pada program P3N KKN Program penyuluhan kami mengkhususkan tentang labelling dan packaging yang akan dilakukan dengan tujuan dikarenakan untuk didesa Sri Kembang I mempunyai Potensi dalam mengolah olahan buah nanas adapun produk tersebut adalah : Dodol, syrup nanas, dan serat nanas. Namun produk tersebut hanya dikenal kalangan lokal saja. Dikarenakan belum adanya label yang pas dan produk masih dikemas secara sederhana. Kemudian tujuan selanjutnya, agar UMKM Pengolahan nanas dan wanita tani tidak hanya berfokus menjual secara sederhana namun ada nilai lebih produk tersebut secara komersial, adapun produk dodol dan syrup nanas yang ada di Desa Sri Kembang I Selalu mengikuti kegiatan seperti pameran, perlombaan secara nasional, dan perlombaan antar desa di Kabupaten Ogan Ilir. Dodol dan Sirup nanas yang ada di Desa Sri Kembang I Sudah memiliki banyak konsumen namun belum terlalu dikomersilkan. Dengan adanya kegiatan penyuluhan ini diharapkan agar kelompok tani dan UMKM Di Desa Sri Kembang I Kecamatan Payaraman agar dapat mandiri dan dapat memperbaiki mulai dari pengemasan yang tidak lagi sederhana dan label yang sudah dipatenkan, dengan harapan untuk meningkatkan nilai jual.

Kata Kunci : Dodol dan sirup nanas, pengemasan, label, nilai jual
Pelatihan Pengolahan Limbah Kulit Udang Menjadi Kaldu Bubuk Pada UMKM Pempek Lela di Desa Sungsang
Authors: Ira Gusti Riani  , Khairunnisa Eka Nurriza , Raudhatus Sa’adah  , Aldilla Sari Utami  , Madyasta Anggana Rarassari  , Nia Boru Ritonga  , Yulia Hapsari  
Published: January 2025

Desa Sungsang merupakan daerah yang terletak di wilayah pesisir Pantai Timur Sumatera. Masyarakat desa Sungsang juga sama seperti masyarakat yang hidup di wilayah pesisir lainnya yaitu memiliki mata pencarian beragam. Salah satu mata pencarian masyarakat sungsang adalah usaha pembuatan pempek udang dimana terdapat pemasalahan berupa kulit udang yang menjadi limbah dari pembuatan pempek dan belum termanfaatkan sehingga menjadi salah satu penyebab pencemaran lingkungan, maka dari itu penting untuk memberikan pengetahuan kepada pelaku pengusaha pempek dan ibu-ibu rumah tangga untuk bisa mengolah limbah tersebut dengan menjadikan kulit udang menjadi kaldu bubuk yang dapat dijual atau digunakan sendiri dirumah. Metode pengabdian yang dilakukan yaitu dengan memberikan praktek langsung. Setelah dilakukan pengabdian, pelaku usaha dan ibu-ibu rumah tangga di desa sungsang 4 mendapatkan pengetahuan baru untuk mengolah limbah menjadi produk yang bernilai. Antusias dan partisipasi ibu-ibu pelaku usaha pempek udang dan ibu-ibu rumah tangga sangat tinggi pada saat mengikuti pelatihan pembuatan kaldu bubuk berbahan limbah kulit udang di Desa Sungsang 4
Methods for Selecting Brittle-Crack-Resistant Structural Materials Based on Polish and International Standards – Part 1
Authors: Graba Marcin , Janusz-Bielecki Mariusz 
Published: January 2025

The article describes the phenomenon of the brittle cracking of steel as a component of structural elements of pressure equipment and construction products. The study presents several methods of analysis used by specialists responsible for the design, fabrication and testing of the aforesaid products. The article also indicates numerous international regulations and standards which can be successfully used in many technical solutions. The methods discussed in the study were compared to enable the selection of appropriate material assessment methods ensuring the safe operation of structures.
The Effect of Water Cooling on the Mechanical Properties of FSW Butt Joints Made of Aluminium Alloy AA7075-T651
Authors: Kosturek Robert , Śnieżek Lucjan , Torzewski Janusz 
Published: January 2025

The article presents test results concerning the mechanical properties of friction stir welded joints (FSW) and underwater friction stir welded joints (UWFSW) made of aluminium alloy AA7075-T651. The analysis of microhardness distribution revealed two positive effects of water cooling, i.e. the reduction of the heat affected zone (HAZ) and an increase in the microhardness of the low hardness zone by approximately 15 HV0.1. Static tensile test results revealed that water cooling led to an increase in the yield point of the FSW joint by approximately 18 % (58 MPa) and tensile strength by approximately 9 % (43 MPa). Under low-cycle fatigue conditions, the UWFSW joints were characterised by higher stress amplitude, lower plastic strain amplitude and a lower number of cycles preceding the failure (of the UWFSW joints) than that preceding the failure of the “classical” FSW joints.
Microstructure of Joints Made of Duplex Steel LDX 2101 Using Concentrated Beams and Various Welding Rates
Authors: Łomozik Mirosław , Urbańczyk Michał , Śliwiński Piotr , Andruszkiewicz Sławomir 
Published: January 2025

The article presents tests concerned with the welding of duplex steel LDX 2101 using a laser beam, an electron beam and various welding rates. Flat butt joints were made using the laser beam and welding rates of 1 m/min and 2 m/min as well as the electron beam and welding rates of 0.2 m/min and 2 m/min. Microscopic metallographic examinations involved the use of light microscopy. The microstructure of individual areas of the test joints was revealed using colour electrolytic etching. Structural components in individual areas of the joints were identified using NIS Elements-AR software tools (Nikon). The same software was used for measuring the width of the joints and the height of excess weld metal. Test results were used to formulate related conclusions.
Development of therapeutic peptide producers based on Escherichia coli BL21 and their cultivation technology
Authors: Khasanshina Z. R. , Kornakov I. A. , Buslaeva E. A. , Kazakova A. V. , Ishchuk S. A. , Shmurak V. I. , Saparova V. B. , Latypov V. F. , Drai R. V. 
Published: January 2025

Introduction. Peptides with a molecular weight of less than 5 kDa have been used in medicine and biotechnology over the past decade for the treatment of various diseases. However, chemical synthesis peptide has several disadvantages, including low yield, reduced efficiency, and high costs. An alternative approach to peptide production is the use of the Escherichia coli expression system. The development of effective peptide synthesis technology remains a critical task because of the low productivity of recombinant strains.Aim. Developing highly efficient strains of Escherichia coli BL21 expressing therapeutic peptides with a molecular weight of less than 5 kDa in E. coli and their cultivation technology.Materials and methods. Genetic constructs were obtained using the restriction-ligase method, and their authenticity was confirmed by Sanger sequencing. Cultivation technology was developed using the Design of Experiments approach. The cultivation condition was validated in the Biostat B bioreactor. Hybrid proteins were purified by metal-chelate chromatography, followed by hydrolysis ULP proteas to obtain the target peptides. The quantitative content of the target protein was determined by capillary electrophoresis, and the authenticity of the protein was confirmed by HPLC-MS and ELISA.Results and discussion. Highly efficient peptide-producing strains were developed. Cultivation conditions were optimized: рН 7.5 ± 0.5, cultivation temperature 37 °C, induction optical density 28 ± 2, IPTG concentration 0.05 мМ. The productivity of the producer strains was up to 4.82 ± 0.05 g/L. Furthermore, samples of the target peptides were isolated and purified.Conclusion. The productivity of peptides in this study were significantly higher than in previous research. The presented strategy for strain development, cultivation and purification technology can be used production of therapeutic peptides with diverse physical chemicals characteristics in the future.
Fosab, but not fosaa, plays important role in learning and memory in fish—insights from zebrafish gene knockout study
Authors: Wang Qiuling , Zhang Lixin , Zhu Chenyuan , Lu Ke , Wu Jiaqi , Liang Xu-Fang 
Published: January 2025

Introduction: Learning and memory allow individuals to adapt to their environmental needs and survive. Fish have the ability to solve complex learning tasks, associative learning, and flexible spatial memory. The proto-oncogene fos (c-fos) has been reported to be involved in brain development, learning and memory in mammals. However, whether the c-fos plays a vital role in learning and memory in fish is unclear.Methods: Almost all fish have two paralogues of c-fos named fosaa and fosab. We used CRISPR/Cas9 technology to generate fosaa and fosab knockout zebrafish models.Results: In this study, we discovered the brain weight marked reduction in fosaa−/− and fosab−/− zebrafish compared with the wild-type (WT) (AB strain) zebrafish. In the T-maze behavioral assay, the fosab−/− zebrafish took significantly more than the average time to complete the assigned trial as the increase in the days compared to WT zebrafish, while the fosaa−/− zebrafish did not show a notable variance. The average time to complete the trial in fosab−/− zebrafish was significantly higher than in WT zebrafish. The relative mRNA expression level of c-jun in fosab−/− zebrafish was significantly higher than that in WT zebrafish, while the fosaa−/− zebrafish has no discernible trend. Additionally, the phylogenetic and multiple amino acid alignment results indicated that fish fosab has a higher identity with mammals Fos.Discussion: By integrating the above results, we found that fosab, but not fosaa, may possess a learning and memory function in fish. For the first time, we illustrated the role of fosaa and fosab in learning and memory via c-fos knockout in fish, which can provide new insights into environmental adaptation.
Gastrointestinal protozoa in pet cats from Anhui province: prevalence and molecular characterization
Authors: Zhang Hao , Tong Xing , Ma Zhonghui , Zhang Tao , Wu Feng , Wu Qiong , Yang Congshan , Han Chunyang 
Published: January 2025

IntroductionTo investigate the prevalence of Tritrichomonas foetus, Pentatrichomonas hominis, Giardia intestinalis, Cryptosporidium, Microsporidium, and Sarcocystis in domestic cats in Anhui Province, China, and their potential role as zoonotic hosts for human infection, a total of 304 fecal samples from two different sources were screened for the presence of related pathogens.MethodsUsing microscopy, along with polymerase chain reaction (PCR) or nested PCR amplification, followed by genotyping through sequence analysis.ResultsThe infection rates of T. foetus, P. hominis, G. intestinalis, Cryptosporidium, Enterocytozoon bieneusi, and Sarcocystis were 5.6%, 0%, 1.7%, 0.7%, 2.6%, and 0%, respectively. The evolutionary relationships and genetic characteristics of G. intestinalis based on the GDH gene, Cryptosporidium based on the SSU rRNA gene, and E. bieneusi based on the ITS sequence were assessed: five cases of G. intestinalis were identified, with four belonging to assemblage F and one to zoonotic assemblage B, two Cryptosporidium cases were identified as Cryptosporidium felis, and all eight E. bieneusi cases were identified as belonging to group 1, with three cases being genotype D, three EbpA, and two EbpC.DiscussionAge, neutering status, and deworming were identified as potential risk factors. Further analysis revealed that diarrhea, as a clinical symptom, could serve as an indicator for pathogen infection. Although the pathogen infection rates detected in this study were relatively low, their zoonotic transmission potential cannot be ignored. Therefore, special attention should be paid, and it is essential to establish targeted prevention plans.
Analysis of factors affecting the clinical management of infection in culture-negative patients following percutaneous endoscopic decompression: a retrospective study
Authors: Qu Changpeng , Wei Haixin , Zhang Hao , Lian Zheng , Lu Hui , Han Shuo 
Published: January 2025

BackgroundCulture-negative spinal infections after prophylactic antibiotic use in percutaneous endoscopic decompression are rare, and diagnostic difficulties and the risk of antibiotic-resistant infections complicate treatment. This study retrospectively analyzed the medical records of culture-negative patients following percutaneous endoscopic surgery to identify risk factors influencing antimicrobial therapy and provide insights for clinical management.MethodsData were retrospectively collected from patients who underwent lumbar percutaneous endoscopic decompression at the Affiliated Hospital of Qingdao University between January 2014 and June 2023. The patients’ medical records were reviewed. Patient demographics, hidden blood loss, daily blood glucose control, and maximum temperature during treatment were recorded as potential risk factors. C-reactive protein, procalcitonin, white blood cells, erythrocyte sedimentation rate, and the duration of antibiotic treatment were used as indicators of infection treatment. The impact of these risk factors on infection was then analyzed.ResultsThe results showed that blood glucose control was strongly correlated with the severity of infection (Beta = 0.60, P = 0.00), strongly correlated with short-term treatment effectiveness (Beta = 0.65, P = 0.00), and moderately correlated with the duration of antibiotic treatment (Beta = 0.41, P = 0.01). Hidden blood loss was moderately correlated with the severity of infection (Partial-R = 0.49, P = 0.00) and moderately correlated with the duration of antibiotic treatment (Partial-R = 0.48, P = 0.00). Hidden blood loss index was moderately correlated with the duration of antibiotic treatment (Partial-R = 0.50, P = 0.00). Female was a favorable factor to shorten the duration of antibiotic treatment (Beta = -0.25, P = 0.01), and higher maximum temperature during infection may indicate a longer duration of antibiotic treatment (Beta = 0.28, P = 0.02).ConclusionOur findings suggest that healthy blood glucose levels, a lower hidden blood loss and hidden blood loss index might help reduce the duration of antibiotic use after infection. Effective hemostasis during surgery to reduce hidden blood loss and good preoperative blood glucose control indicators are both beneficial measures for infection treatment.
Sense of agency in gesture-based interactions: modulated by sensory modality but not feedback meaning
Authors: Evangelou George , Georgiou Orestis , Brown Eddie , Moore James W. 
Published: January 2025

IntroductionGesture-based interactions provide control over a system without the need for physical contact. Mid-air haptic technology allows a user to not visually engage with the interface while receiving system information and is readily manipulable, which has positive implications for automotive environments. It is important, however, that the user still feels a sense of agency, which here refers to perceiving system changes as caused by their gesture.MethodsIn the current study, 36 participants engaged in an experimental time perception task with an automotive-themed infotainment menu, serving as an implicit quantitative measure of agency. This was supplemented with additional self-reported measures. They selected different icons via gesture poses, with sensory feedback either visually or haptically. In addition, (sensory) feedback was also the same for each icon, arbitrarily different or carried semantic information.ResultsMid-air haptics increased agency compared to visual, and this did not vary as a function of feedback meaning. Agency was also associated with general measures of trust and usability.DiscussionOur findings demonstrate positive implications for mid-air haptics in automotive contexts and highlight the general importance of user agency.
Unveiling the digital future: perspectives of Hungarian physicians under 35 years old on eHealth solutions
Authors: Győrffy Zsuzsa , Döbrössy Bence , Boros Julianna , Girasek Edmond 
Published: January 2025

BackgroundThe COVID-19 pandemic has catalysed the emergence of digital solutions in all areas of medicine. Our prior study on the digital health related experiences and opinions of Hungarian physicians highlights the crucial role of age in shaping attitudes towards digital health solutions among medical doctors. Our aim was to examine how under 35-year-old Hungarian physicians relate to digital technologies, the advantages and disadvantages they perceive, and how they would like to incorporate these technologies into their everyday medical practice.MethodsAs part of the “E-physicians and E-patients in Hungary” study, we conducted an online representative survey among medical practitioners in Hungary between July 2021 and May 2022 (n = 1,774). The main target group of our research were physicians under 35 years of age: n = 399 (25.3%). Besides descriptive statistical analyses, cluster analysis and binary logistic regression were applied to analyse the digital health related attitudes of the young age group.ResultsOur cluster analysis confirmed that younger doctors perceived more advantages (on average 7.07 items vs. 8.52 items) and disadvantages (on average 4.06 vs. 4.42) of digital health solutions. They also demonstrated greater familiarity with (8.27 vs. 9.79) and use of (1.94 vs. 2.66) a broader spectrum of technologies. Proficiency and active utilization of diverse technologies correlates with a more comprehensive understanding of both pros and cons, as well as a more realistic self-assessment of areas of further improvement. Doctors under 35 years express a notable demand for significantly increased incentives, both in terms of knowledge transfer/training and infrastructure incentives. Multivariate analyses revealed that young doctors, compared to their older counterparts, perceived enhanced patient adherence as one of the greatest benefits of digital health solutions. Additionally, young doctors expect that digital health solutions could reduce burnout.ConclusionOur results underscore the inevitable transformation of the 21st-century physician role: the success of digital health solutions hinges on active patient involvement and management, which requires proper patient education and professional support in navigating the digital space. Digital health solutions can be a bridge between different generations of doctors, where young people can help their older colleagues navigate the digital world.
Spatial and social relevance perceptions by pre-service teachers of learning about oil palm management as a local or nonlocal socioscientific issue
Authors: Matthiesen Finn Kristen , Nolte Gina , Rehling Finn , Arjana I Gede , Sitompul Lola Utama , Yelianti Upik , Bögeholz Susanne 
Published: January 2025

IntroductionPre-service teachers (PST)' perceived relevance of learning about environmental socioscientific issues (SSI) can be an indicator for their motivation to act as change agents. Until now, science education (research) has often addressed the relevance for learning about SSI insufficiently differentiated regarding spatial and social dimensions. However, theoretical frameworks suggest that such differentiation enhances meaningful teaching and learning. This study investigated how local, national, and global subdimensions of spatial relevance as well as individual, societal, and professional subdimensions of social relevance influence PST' relevance perceptions of learning about SSI. Additionally, we examined how relevance perceptions vary depending on whether the SSI is local or nonlocal to PST. We specifically investigated Indonesian PST' relevance perceptions of learning about oil palm management (OPM), a local SSI for PST of one university and a nonlocal SSI for PST of two other universities.MethodsThe PST participated in a 5-week socioscientific inquiry-based educational unit on OPM in curricular courses (N = 111). We followed a mixed-method approach, employing measurements of utility value. Utility value is a specific construct of perceived relevance, which refers to the usefulness of learning about objects for a person's life, profession, and society. Quantitatively, we conducted pretest-posttest-follow-up surveys on PST' perceived utility value for learning about OPM over time. Qualitatively, we analyzed responses to a utility value reflection task that was integrated into the unit.ResultsOverall, the unit increased PST' utility value over time. Local PST perceived lower utility value for learning about OPM than nonlocal PST. In the task responses, local PST referred more to the local subdimension, whereas nonlocal PST referred more to the national subdimension. Nonlocal PST' societal and professional utility value increased stronger over time compared to local PST.DiscussionWe discuss potential reasons for local PST' lower relevance perceptions, e.g., personal experiences and skepticism through local embeddedness. Our findings on relevance perceptions among local and nonlocal PST underscore the importance of spatial- and social-sensitive SSI education. We point out practical implications for promoting relevance perceptions considering local and nonlocal PST. Moreover, we suggest research directions for more differentiated relevance research in science education.
Cost-effectiveness analysis of three surgical approaches for parathyroidectomy in secondary hyperparathyroidism patients
Authors: Sa Qila , Zhou Yinghui , Cheng Guangming , Nan Boyuan , Feng Yingnan , Zhang Ningyuan , Xie Wantao , Zhang Wei 
Published: January 2025

BackgroundThere are three main surgical treatment options for secondary hyperparathyroidism (SHPT): subtotal parathyroidectomy (sPTX), total parathyroidectomy with auto-transplantation (tPTX+AT), and total parathyroidectomy (tPTX). However, a debate regarding which of these surgical methods is optimal has been ongoing. Aim of this study is to compare medical costs and final outcomes associated with the three surgical approaches for the entire treatment duration, aiming to identify the most cost-effective surgical method.MethodsBased on previous research data from domestic and international studies, as well as data from on-site surveys, TreeAge Pro 2022 software was used to construct a Markov model for the surgical treatment of SHPT patients. The model was run using data from the 2022 registered population of end-stage renal disease dialysis patients in China (1 million) as baseline cohort. Main indicators for this analysis are total cost, quality-adjusted life years, and incremental cost-effectiveness ratio (ICER). The study period is 10 years post-surgery, with a discount rate of 5% per year. Uncertainty in the model was assessed using one-way sensitivity analysis and probabilistic sensitivity analysis (PSA).ResultsThe costs incurred by SHPT patients undergoing sPTX, tPTX, and tPTX+AT within 10 years post-surgery are $7042.54, $9983.00, and $11435.60, respectively, with total utilities generated being 13.23 QALYs, 18.76 QALYs, and 18.69 QALYs. Compared to sPTX, the incremental costs and incremental effects of tPTX and tPTX+AT are $2,924.71 and $4,456.66, with 5.53 QALYs and 5.46 QALYs, respectively. The ICER for tPTX and tPTX+AT groups are $532.13/QALY and $805.10/QALY, respectively, which are well below our set willingness-to-pay (WTP) threshold. Sensitivity analysis results indicate that varying any parameter within a certain range over the given time interval will not cause the ICER to exceed the WTP threshold and will not reverse the primary analysis results.ConclusionIn the Chinese healthcare system, tPTX is considered the most cost-effective treatment for refractory hyperparathyroidism, when compared to tPTX+AT and sPTX.