bluuebunny/crossref_metadata_2025_split huggingface dataset:
News and Markets in the Time of COVID-19
Authors: Mamaysky Harry 
Published: October 2023

AbstractThe onset of COVID-19 was characterized by voluminous, negative news. Higher narrativity news topics (measured by textual proximity to articles describing the 1987 stock market crash and textual distance from Federal Reserve communications) were systematically associated with contemporaneous market responses, which were larger on high volatility days (hypersensitivity), and with markets–news feedback. Hypersensitive news topic-market pairs were associated with next-day reversals. A test using the news–markets relationship identifies a mid-March 2020 structural break, which was knowable by the end of April. Post break, markets and news became considerably less coupled, and hypersensitivity and reversals abated.
Inseparable operations and the human operation of Christ
Authors: Duby Steven J. 
Published: October 2023

AbstractThe recent recovery of the teaching that the three divine persons share one operation in their outward works raises the question of whether or in what sense the human operation of Christ belongs to the Son alone. My thesis is that all three divine persons move and support the Son's human operation while the Son alone is the proper subject of his human operation. In order to substantiate this thesis, I will consider two main issues: (1) the relationship between divine movement and human energy and (2) the relationship between nature and person in Christ's human action.
Contrasting the semantic typology biases of Deaf and hearing nonsigners in their conceptualization of time and space
Authors: Macedo María Noel , Yerro Matías , Vivas Jorge , Castillo Mauricio , Meliande Maximiliano , de León Adriana , Fojo Alejandro , Aguirre Roberto 
Published: October 2023

AbstractThe mental lexicon offers a window into the configuration of conceptual domains such as space and time, which has been labeled as concrete the former and abstract the latter in the current embodiment approach to cognition. Space has a phonological and semantic value in sign languages, but not in spoken languages. Additionally, the representation of time by spatial means is robust in oral and sign languages. This research asks if Deaf signers and hearing nonsigners have the same conceptual organization of those domains. In their respective languages, sixty-two participants made a repeated free word association task. These results showed that the studied populations have a little overlap in the associates evocated for each clue. The analysis of the preferences of the semantic relations of the pairs clue-associate showed a greater tendency of the Deaf signers to establish thematic relations. In contrast, the hearing participants indicated a bias toward taxonomic relations. The results suggest that the abstractness or concreteness of concepts may be modulated by factors associated with linguistic modalities. However, in this compared free association norms factors related to the language deprivation of Deaf, the asymmetries in the cross-modal language contact and cross-modal borrowing were not exhaustively controlled.
Organizing Dots and Lines: Eastern Hui and the Adaptation of the CCP's Nationalities Work in the Revolutionary Era
Authors: Glasserman Aaron Nathan 
Published: October 2023

AbstractAlthough ethnic governance in the People's Republic of China is often portrayed as a matter of controlling “minority nationalities” in the country's frontier regions, the ethnic affairs bureaucracy operates in every province. The origins of “nationalities work” as a discrete domain of governance can be traced to the Chinese Communist Party's efforts to mobilize scattered Hui communities in the eastern provinces of Shandong and Hebei in the 1930s–1940s. Thanks to the initiative of Hui Communists, local Party leaders came to understand that Hui were not simply scattered but interconnected. They adapted and replicated organizational methods to exploit Hui networks for gathering intelligence, smuggling goods and penetrating enemy-controlled cities. This history offers an instructive case of adaptive governance in the revolutionary period and the role of ethnic minority cadres in policy entrepreneurship. It also underscores the importance of the Party's experience in eastern China in the study of Chinese ethnic policy.
Giant early post-surgical aneurysm of the aortic arch in an infant
Authors: Cruz Hernández Angel , Ortiz José L. Colín , Silva Estrada Jorge A. 
Published: October 2023

AbstractTen-day-old neonate who underwent correction of interrupted aortic arch developed a giant early post-surgical aneurysm. To our knowledge, this unusual complication has been only reported as a late complication.
NON-FACTIVE KOLMOGOROV CONDITIONALIZATION
Authors: RESCORLA MICHAEL 
Published: October 2023

Abstract
Kolmogorov conditionalization is a strategy for updating credences based on propositions that have initial probability 0. I explore the connection between Kolmogorov conditionalization and Dutch books. Previous discussions of the connection rely crucially upon a factivity assumption: they assume that the agent updates credences based on true propositions. The factivity assumption discounts cases of misplaced certainty, i.e., cases where the agent invests credence 1 in a falsehood. Yet misplaced certainty arises routinely in scientific and philosophical applications of Bayesian decision theory. I prove a non-factive Dutch book theorem and converse Dutch book theorem for Kolmogorov conditionalization. The theorems do not rely upon the factivity assumption, so they establish that Kolmogorov conditionalization has unique pragmatic virtues that persist even in cases of misplaced certainty.
Quantifying the Contribution of Salinity Effect to the Seasonal Variability of the Makassar Strait Throughflow
Authors: Lu Xi , Hu Shijian , Guan Cong , Li Mingting , Sprintall Janet , Wang Fan 
Published: October 2023

AbstractThe Makassar Strait throughflow (MST) constitutes a significant component of the Indonesian throughflow (ITF) and plays a pivotal role in the interbasin exchange between the Indian and Pacific Oceans. While previous studies have suggested that the buoyancy forcing plays a role in influencing the seasonality of the MST, the quantitative contribution of salinity effect on MST seasonality remains unclear. Here we use the measurements from the Monitoring ITF program and the Global Ocean Physics Reanalysis product to investigate the seasonality of MST and quantify the impact of the salinity effect. We find that the halosteric variability due to the salinity effect contributes to approximately (69.6 ± 11.7) % of the total seasonal variability of surface dynamic height gradient along the Makassar Strait, and dominates the seasonality of the upper layer MST. The primary drivers for freshwater forcing are horizontal advection through the Karimata Strait and precipitation in the Java Sea.
Serpentinite Dehydration and Olivine Vein Formation During Ductile Shearing: Insights From 2D Numerical Modeling on Porosity Generation, Density Variations, and Transient Weakening
Authors: Schmalholz Stefan M. , Moulas Evangelos , Räss Ludovic , Müntener Othmar 
Published: October 2023

AbstractSerpentinite dehydration is important for subduction zone dynamics and water cycling. Field observations suggest that en échelon olivine veins in serpentinite mylonites formed by dehydration during simultaneous shearing of antigorite serpentinite. Here, we test the hypothesis of shear‐driven formation of olivine dehydration veins with a novel two‐dimensional hydro‐mechanical‐chemical numerical model. Our model accounts for the reaction antigorite + brucite = forsterite + water, considering significant solid density changes of approximately 25%. We assume ductile shearing, a decrease of shear viscosity with increasing porosity, and initially homogeneous total and fluid pressures within the serpentinite stability field. Initial perturbations in porosity, and hence viscosity, cause fluid pressure perturbations during simple shearing. Dehydration nucleates where fluid pressure locally drops below the thermodynamic pressure controlling the reaction boundary. During shearing, dehydration veins grow and serpentinite transforms into olivine inside the veins. Simulations show that the ambient pressure and the relation between compaction length and porosity have a major impact on vein formation. Conversely, the orientation of the initial porosity perturbation, the pressure‐insensitive yield stress, the porosity dependence of compaction viscosity, the elastic effects during compaction, and the reaction kinetics have minor impacts on the simulations. We quantify the relative contribution of the rates of solid volume change, solid density change, and reactive mass transfer to the porosity generation. Vein growth is self‐limiting and eventually reaches a steady state. We discuss potential implications for natural olivine veins, slow slip and tremor, transient weakening, anisotropy generation, and formation of shear‐driven high‐porosity bands without a dehydration reaction.
Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells
Authors: Moon Joon Ho , Lee Joonyub , Kim Kyun Hoo , Kim Hyun Jung , Kim Hyeongseok , Cha Hye-Na , Park Jungsun , Lee Hyeonkyu , Park So-young , Jang Hak Chul , Kim Hail 
Published: October 2023

AbstractPregnancy imposes a substantial metabolic burden on women, but little is known about whether or how multiple pregnancies increase the risk of maternal postpartum diabetes. In this study, we assessed the metabolic impact of multiple pregnancies in humans and in a rodent model. Mice that underwent multiple pregnancies had increased adiposity, but their glucose tolerance was initially improved compared to those of age-matched virgin mice. Later, however, insulin resistance developed over time, but insulin secretory function and compensatory pancreatic β cell proliferation were impaired in multiparous mice. The β cells of multiparous mice exhibited aging features, including telomere shortening and increased expression of Cdkn2a. Single-cell RNA-seq analysis revealed that the β cells of multiparous mice exhibited upregulation of stress-related pathways and downregulation of cellular respiration- and oxidative phosphorylation-related pathways. In humans, women who delivered more than three times were more obese, and their plasma glucose concentrations were elevated compared to women who had delivered three or fewer times, as assessed at 2 months postpartum. The disposition index, which is a measure of the insulin secretory function of β cells, decreased when women with higher parity gained body weight after delivery. Taken together, our findings indicate that multiple pregnancies induce cellular stress and aging features in β cells, which impair their proliferative capacity to compensate for insulin resistance.
Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice
Authors: Hou Xiaoting , Chen Yangshan , Zhou Bo , Tang Wanze , Ding Zhen , Chen Litong , Wu Yun , Yang Hongyu , Du Changzheng , Yang Dazhi , Ma Guixing , Cao Huiling 
Published: October 2023

AbstractInsufficient pancreatic β-cell mass and reduced insulin expression are key events in the pathogenesis of diabetes mellitus (DM). Here we demonstrate the high expression of Talin-1 in β-cells and that deficiency of Talin-1 reduces β-cell proliferation, which leads to reduced β-cell mass and insulin expression, thus causing glucose intolerance without affecting peripheral insulin sensitivity in mice. High-fat diet fed exerbates these phenotypes. Mechanistically, Talin-1 interacts with the E3 ligase smad ubiquitination regulatory factor 1 (Smurf1), which prohibits ubiquitination of the signal transducer and activator of transcription 3 (Stat3) mediated by Smurf1, and ablation of Talin-1 enhances Smurf1-mediated ubiquitination of Stat3, leading to decreased β-cell proliferation and mass. Furthermore, haploinsufficiency of Talin-1 and Stat3 genes, but not that of either gene, in β-cell in mice significantly impairs glucose tolerance and insulin expression, indicating that both factors indeed function in the same genetic pathway. Finally, inducible deletion Talin-1 in β-cell causes glucose intolerance in adult mice. Collectively, our findings reveal that Talin-1 functions as a crucial regulator of β-cell mass, and highlight its potential as a therapeutic target for DM patients.
Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53
Authors: Zhong Dandan , Quan Lingling , Hao Chang , Chen Jingshuo , Qiao Ranran , Lin Tengfei , Ying Changjiang , Sun Dong , Jia Zhanjun , Sun Ying 
Published: October 2023

AbstractAcute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality but no specific therapy. Microsomal prostaglandin E synthase-2 (mPGES-2) is a PGE2 synthase but can metabolize PGH2 to malondialdehyde by forming a complex with heme. However, the role and mechanism of action of mPGES-2 in AKI remain unclear. To examine the role of mPGES-2, both global and tubule-specific mPGES-2-deficient mice were treated with cisplatin to induce AKI. mPGES-2 knockdown or overexpressing HK-2 cells were exposed to cisplatin to cause acute renal tubular cell injury. The mPGES-2 inhibitor SZ0232 was used to test the translational potential of targeting mPGES-2 in treating AKI. Additionally, mice were subjected to unilateral renal ischemia/reperfusion to further validate the effect of mPGES-2 on AKI. Interestingly, both genetic and pharmacological blockage of mPGES-2 led to decreased renal dysfunction and morphological damage induced by cisplatin and unilateral renal ischemia/reperfusion. Mechanistic exploration indicated that mPGES-2 deficiency inhibited ferroptosis via the heme-dependent regulation of the p53/SLC7A11/GPX4 axis. The present study indicates that mPGES-2 blockage may be a promising therapeutic strategy for AKI.
Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers
Authors: Merkenschlager Julia , Berz Riza-Maria , Ramos Victor , Uhlig Maximilian , MacLean Andrew J. , Nowosad Carla R. , Oliveira Thiago Y. , Nussenzweig Michel C. 
Published: October 2023

AbstractFollicular helper T cells (TFH) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (TFR) prevent the emergence of self-reactive B cells and help to extinguish the reaction. Here we show that GC reactions continually recruit T cells from both the naïve conventional and naive thymic regulatory T cell (Treg) repertoires. In the early GC, newly recruited T cells develop into TFH, whereas cells entering during the contraction phase develop into TFR cells that contribute to GC dissolution. The TFR fate decision is associated with decreased antigen availability and is modulated by slow antigen delivery or mRNA vaccination. Thus, invasion of ongoing GCs by newly developing TFH and TFR helps remodel the GC based on antigen availability.
Extracting medicinal chemistry intuition via preference machine learning
Authors: Choung Oh-Hyeon , Vianello Riccardo , Segler Marwin , Stiefl Nikolaus , Jiménez-Luna José 
Published: October 2023

AbstractThe lead optimization process in drug discovery campaigns is an arduous endeavour where the input of many medicinal chemists is weighed in order to reach a desired molecular property profile. Building the expertise to successfully drive such projects collaboratively is a very time-consuming process that typically spans many years within a chemist’s career. In this work we aim to replicate this process by applying artificial intelligence learning-to-rank techniques on feedback that was obtained from 35 chemists at Novartis over the course of several months. We exemplify the usefulness of the learned proxies in routine tasks such as compound prioritization, motif rationalization, and biased de novo drug design. Annotated response data is provided, and developed models and code made available through a permissive open-source license.
A genome-scale metabolic model of parasitic whipworm
Authors: Bay Ömer F. , Hayes Kelly S. , Schwartz Jean-Marc , Grencis Richard K. , Roberts Ian S. 
Published: October 2023

AbstractGenome-scale metabolic models are widely used to enhance our understanding of metabolic features of organisms, host-pathogen interactions and to identify therapeutics for diseases. Here we present iTMU798, the genome-scale metabolic model of the mouse whipworm Trichuris muris. The model demonstrates the metabolic features of T. muris and allows the prediction of metabolic steps essential for its survival. Specifically, that Thioredoxin Reductase (TrxR) enzyme is essential, a prediction we validate in vitro with the drug auranofin. Furthermore, our observation that the T. muris genome lacks gsr-1 encoding Glutathione Reductase (GR) but has GR activity that can be inhibited by auranofin indicates a mechanism for the reduction of glutathione by the TrxR enzyme in T. muris. In addition, iTMU798 predicts seven essential amino acids that cannot be synthesised by T. muris, a prediction we validate for the amino acid tryptophan. Overall, iTMU798 is as a powerful tool to study not only the T. muris metabolism but also other Trichuris spp. in understanding host parasite interactions and the rationale design of new intervention strategies.
Robust 2D layered MXene matrix–boron carbide hybrid films for neutron radiation shielding
Authors: Han Ju-Hyoung , Seok Shi-Hyun , Jin Young Ho , Park Jaeeun , Lee Yunju , Yeo Haeng Un , Back Jong-Ho , Sim Yeoseon , Chae Yujin , Wang Jaewon , Oh Geum-Yoon , Lee Wonjoo , Park Sung Hyun , Bang In-Cheol , Kim Ji Hyun , Kwon Soon-Yong 
Published: October 2023

AbstractLarge-scale fabrication of neutron-shielding films with flexible or complex shapes is challenging. Uniform and high boron carbide (B4C) filler loads with sufficient workability are needed to achieve good neutron-absorption capacity. Here, we show that a two-dimensional (2D) Ti3C2Tx MXene hybrid film with homogeneously distributed B4C particles exhibits high mechanical flexibility and anomalous neutron-shielding properties. Layered and solution-processable 2D Ti3C2Tx MXene flakes serve as an ideal robust and flexible matrix for high-content B4C fillers (60 wt.%). In addition, the preparation of a scalable neutron shielding MXene/B4C hybrid paint is demonstrated. This composite can be directly integrated with various large-scale surfaces (e.g., stainless steel, glass, and nylon). Because of their low thickness, simple and scalable preparation method, and an absorption capacity of 39.8% for neutrons emitted from a 241Am9Be source, the 2D Ti3C2Tx MXene hybrid films are promising candidates for use in wearable and lightweight applications.
Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease
Authors: Harada Takuya , Kikushige Yoshikane , Miyamoto Toshihiro , Uno Kazuko , Niiro Hiroaki , Kawakami Atsushi , Koga Tomohiro , Akashi Koichi , Yoshizaki Kazuyuki 
Published: October 2023

AbstractCastleman disease (CD) is a rare lymphoproliferative disorder. Among subtypes of CD, idiopathic multicentric CD-not otherwise specified (iMCD-NOS) has a poor prognosis and its pathogenesis is largely unknown. Here we present a xenotransplantation model of iMCD-NOS pathogenesis. Immunodeficient mice, transplanted with lymph node (LN) cells from iMCD-NOS patients, develop iMCD-like lethal inflammation, while mice transplanted with LN cells from non-iMCD patients without inflammation serve as negative control. Grafts depleted of human CD3+ T cells fail to induce inflammation in vivo. Upon engraftment, peripheral helper T (Tph) cells expand and levels of human CXCL13 substantially increase in the sera of mice. A neutralizing antibody against human CXCL13 blocks development of inflammation and improves survival in the recipient mice. Our study thus indicates that Tph cells, producing CXCL13 play a critical role in the pathogenesis of iMCD-NOS, and establishes iMCD-NOS as an immunoregulatory disorder.
Organic photodiodes with bias-switchable photomultiplication and photovoltaic modes
Authors: Liu Qingxia , Li Lingfeng , Wu Jiaao , Wang Yang , Yuan Liu , Jiang Zhi , Xiao Jianhua , Gu Deen , Li Weizhi , Tai Huiling , Jiang Yadong 
Published: October 2023

AbstractThe limited sensitivity of photovoltaic-type photodiodes makes it indispensable to use pre-amplifier circuits for effectively extracting electrical signals, especially when detecting dim light. Additionally, the photomultiplication photodiodes with light amplification function suffer from potential damages caused by high power consumption under strong light. In this work, by adopting the synergy strategy of thermal-induced interfacial structural traps and blocking layers, we develop a dual-mode visible-near infrared organic photodiode with bias-switchable photomultiplication and photovoltaic operating modes, exhibiting high specific detectivity (~1012Jones) and fast response speed (0.05/3.03 ms for photomultiplication-mode; 8.64/11.14 μs for photovoltaic-mode). The device also delivers disparate external quantum efficiency in two optional operating modes, showing potential in simultaneously detecting dim and strong light ranging from ~10−9to 10−1 W cm−2. The general strategy and working mechanism are validated in different organic layers. This work offers an attractive option to develop bias-switchable multi-mode organic photodetectors for various application scenarios.
White matter changes in Parkinson’s disease
Authors: Yang Kai , Wu Zhengqi , Long Jie , Li Wenxin , Wang Xi , Hu Ning , Zhao Xinyue , Sun Taolei 
Published: October 2023

AbstractParkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). It is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the formation of Lewy bodies (LBs). Although PD is primarily considered a gray matter (GM) disease, alterations in white matter (WM) have gained increasing attention in PD research recently. Here we review evidence collected by magnetic resonance imaging (MRI) techniques which indicate WM abnormalities in PD, and discuss the correlations between WM changes and specific PD symptoms. Then we summarize transcriptome and genome studies showing the changes of oligodendrocyte (OLs)/myelin in PD. We conclude that WM abnormalities caused by the changes of myelin/OLs might be important for PD pathology, which could be potential targets for PD treatment.