bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastasiertes kastrationsresistentes Prostatakarzinom: Welche Sequenzen sind am sinnvollsten?
Authors: Horak Jana , Petrausch Ulf , Omlin Aurelius 
Published: October 2023

Zusammenfassung
Hintergrund
Beim fortgeschrittenen Prostatakarzinom bezeichnet man die Krankheitsprogression unter der laufenden Androgendeprivation (ADT) als Kastrationsresistenz (CRPC). Für die Behandlung stehen verschiedene therapeutische Modalitäten zu Verfügung (endokrine Therapien, Chemotherapien, PARP-Inhibition, Radionuklid- und Radioligandentherapie).

Ziel der Arbeit
In dieser Arbeit werden praktische Aspekte und Überlegungen zur Sequenztherapie ausgeführt.

Material und Methoden
Die Ausführungen beruhen auf den vorhandenen prospektiven Phase-III-Studien, welche einen klinisch relevanten und statistisch signifikanten Vorteil im radiographisch progressionsfreien und/oder Gesamtüberleben nachweisen konnten.

Ergebnisse
Die Sequenztherapie ist neben vielen individuellen patientenbezogenen Faktoren abhängig von der Behandlung, welche Patienten in der hormonsensitiven Situation (mHSPC) erhalten haben. Nach Vorbehandlung mit ADT alleine oder ADT plus Docetaxel in der mHSPC-Situation, ist eine zusätzliche endokrine Therapie der Standard. Bei Progress unter einer kombinierten endokrinen Therapie, welche in der mHSPC-Situation gestartet wurde, ist aktuell Docetaxel für die Mehrheit der Patienten der Standard. Patienten mit Triplet-Vorbehandlung in der mHSPC-Situation können mit einer Radioligandentherapie oder mit einer Zweitlinienchemotherapie behandelt werden.

Schlussfolgerung
Für Patienten mit mCRPC stehen verschiedene, aktive und gut verträgliche Therapiemöglichkeiten zu Verfügung. Der Einsatz richtet sich primär nach den bereits erfolgten Vortherapien aber viele weitere, individuelle Faktoren werden mitberücksichtigt.
Clinical outcomes of 3T magnetic resonance imaging-guided lumbar and sacral foraminal injections
Authors: Guillemin Pauline C. , Salomir Rares , Lauper Nicolas , Lorton Orane , Maturana Enrique , Stöckli Alex , Poletti Pierre-Alexandre , Dominguez Dennis E. , Boudabbous Sana , Scheffler Max 
Published: October 2023

Abstract
Purpose
This article evaluates the feasibility, safety, and efficacy of MRI-guided lumbar or sacral nerve root infiltration for chronic back pain. We compared the outcomes of our MRI-guided infiltrations with data from CT-guided infiltrations reported in the literature and explored the potential advantages of MRI guidance.

Method
Forty-eight MRI-guided nerve root infiltrations were performed using a 3 T MRI machine. The optimal needle path was determined using breathhold T2-weighted sequences, and the needle was advanced under interleaved guidance based on breathhold PD-weighted images. Pain levels were assessed using a numeric rating scale (NRS) before the procedure and up to 5 months after, during follow-up. Procedure success was evaluated by comparing patients’ pain levels before and after the infiltration.

Results
The MRI-guided infiltrations yielded pain reduction 1 week after the infiltration in 92% of cases, with an average NRS substantial change of 3.9 points. Pain reduction persisted after 5 months for 51% of procedures. No procedure-related complications occurred. The use of a 22G needle and reconstructed subtraction images from T2 FatSat sequences improved the workflow.

Conclusion
Our study showed that MRI-guided nerve root infiltration is a feasible, safe, and effective treatment option for chronic back pain. Precise positioning of the needle tip and accurate distribution of the injected solution contributed to the effectiveness of MRI-guided infiltration, which appeared to be as accurate as CT-guided procedures. Further research is needed to explore the potential benefits of metal artifact reduction sequences to optimize chronic back pain management.
Safety of esthetic procedures in rheumatic patients: single-center survey of patients
Authors: Felis-Giemza Anna , Matusiewicz Agata , Wajda Anna , Olesińska Marzena 
Published: October 2023

AbstractThe popularity of esthetic medicine is growing every year, also among patients with autoimmune inflammatory rheumatic diseases (AIRD). The objective of this study was to evaluate the safety of esthetic medicine (AM) procedures in patients with AIRD. A semi-structured, anonymous questionnaire regarding rheumatic and concomitant diseases and AM procedures was distributed among adult patients hospitalized in the rheumatology department or attending outpatient clinic in the National Institute of Geriatrics, Rheumatology, and Rehabilitation, Warsaw. The main outcome was the occurrence of an adverse event. A number of 512 patients took part in the survey and 15 were excluded (AM procedure preceded the diagnosis of AIRD). The study group consisted of 497 patients, of whom 47 had undergone AM procedures. The procedures performed included: tattooing (22 patients), piercing (16 patients), hyaluronic acid (7 patients), botulinum toxin (5 patients) injections, laser procedures (6 patients), plastic surgery (4 patients), mesotherapy (3 patients) and others. The vast majority of patients had these performed during remission or low disease activity. 70.2% of patients received treatment with disease-modifying antirheumatic drugs (DMARDs) during the AM procedure, with TNF-alfa inhibitors being the most common (63.6%). Adverse events occurred in 15% of patients. All were mild and transient site reactions. Most patients would like to repeat the AM procedure in the future. The use of esthetic medicine procedures in patients with AIRD, including those treated with biologic DMARDs, was associated with a risk of mild site reactions. Most of the patients expressed satisfaction with the results of the AM procedure.
Survey on the working, training, and research conditions of resident physicians in internistic and rheumatological continuing education—BEWUSST
Authors: Proft Fabian , Vossen Diana , Baraliakos Xenofon , Berliner Michael N. , Fleck Martin , Keyßer Gernot , Krause Andreas , Lorenz Hanns-Martin , Manger Bernhard , Schuch Florian , Specker Christof , Wollenhaupt Jürgen , Voormann Anna , Raspe Matthias , Krusche Martin , Pfeil Alexander ,   Kommission Fort- und Weiterbildung der Deutschen Gesellschaft für Rheumatologie
Published: October 2023

Abstract
Background
Data on the training and continuing education situation of residents in the field of internal medicine and rheumatology are not available for Germany. For this reason, the Commission for Education and Training of the German Society of Rheumatology (DGRh) initiated the BEWUSST survey on the working, training and research conditions of residents in rheumatology.

Methods
A total of 102 questions on the topics of working conditions in everyday professional life, continuing medical education and training, compatibility of career and family, compatibility of work and research, perspectives as a rheumatologist and practical activities were included in an online questionnaire.

Results
A total of 102 participants took part in the survey. Of the respondents 48.1% were satisfied with their professional situation, 40.2% of the participants were supervised by a specialist mentor and 54.9% were working as scientists during their work as a physician. A compatibility of family and career was possible for 34.7%. After completion of the residency 52.9% of the respondents aspired to a combined clinical and outpatient activity.

Conclusion
Half of the trainee rheumatologists are satisfied with their professional activities, although mentoring of the assistants in training should be further improved. With respect to the desired combined clinical and outpatient activity, the existing options should be expanded or new professional fields of activity should be established, so that the specialty remains attractive for the upcoming generations.
Möglichkeiten des Aortenklappenersatzes beim jungen Erwachsenen: dezellularisierte menschliche Spenderklappen
Authors: Sarikouch Samir , Ruhparwar Arjang , Horke Alexander 
Published: October 2023

Zusammenfassung
Hintergrund
Die Wahl des Aortenklappenersatzverfahrens beim jungen erwachsenen Patienten hat viele verschiedene Aspekte zu berücksichtigen.

Fragestellung
Vergleich der Ergebnisse der Ross-Operation, des mechanischen und biologischen Klappenersatzes sowie konventioneller und dezellularisierter Homografts beim Aortenklappenersatz bei jungen Erwachsenen.

Ergebnisse
Für die Ross-Operation werden Freiheiten von Reoperation an Autograft und pulmonalem Homograft von 92,0 resp. 97,2 % nach 15 Jahren berichtet. Dennoch wurden in 2021 nur bei 1,9 % aller chirurgischen Aortenklappenimplantationen eine Ross-Operation durchgeführt, was die Übertragbarkeit der Ergebnisse auf den individuellen Patienten limitiert. Biologische, xenogene Aortenklappen stellen aufgrund rascher Degeneration für sehr junge Patienten keine Option dar. Der mechanische Aortenklappenersatz ist das Standardverfahren beim jungen Erwachsenen, das Risiko für schwere Komplikationen wie bedrohliche Blutungen oder Thromboembolien, bedingt durch die notwendige Antikoagulation, wird auf ca. 2 % pro Patientenjahr geschätzt. Das Langzeitüberleben zeigte sich gegenüber der Normalbevölkerung nach Implantation einer mechanischen Herzklappe in großen Metaanalysen reduziert.
Dezellularisierte menschliche Spenderklappen stellen eine neue Option für den Aortenklappenersatz bei jungen Erwachsenen dar. In einer prospektiven Studie waren die 5‑Jahres-Ergebnisse vergleichbar mit denen prominenter Ross-Kohorten trotz doppelt so vieler kardialer Voroperationen. Die Freiheiten von Tod, Reoperation, Endokarditis, Blutungen und Thromboembolien betrugen 97,8 %, 93,5 %, 96,4 %, 99,2 % resp. 99,3 %. Hauptzielgruppe sind junge Patienten mit Indikation zum Wurzelersatz, bei denen eine Antikoagulation vermieden werden soll und eine Ross-Operation nicht möglich/erwünscht ist.
Coherent lamellar intergrowth in alkali feldspar
Authors: Petrishcheva E. , Heuser D. , Abart R. 
Published: October 2023

AbstractA thermodynamic analysis of coherent lamellar intergrowth resulting from the exsolution of initially homogeneous alkali feldspar is presented. In contrast to earlier treatments, where the simplifying assumption of zero strain in the lamellar interfaces was used, our treatment is more general. The elastic stresses and strains associated with coherent lamellar intergrowth of Na-rich and K-rich alkali feldspar are calculated by minimising the overall elastic energy of the lamellar microstructure. At given pressure and temperature, the elastic energy depends on the volume proportions of the two lamellar types, and thus on the composition of the homogeneous precursor feldspar. As a consequence, there is no single coherent solvus for alkali feldspar, but coherent solvi are different for different compositions of the homogeneous precursor phase. Experimentally observed lamellar orientations agree with those predicted by minimising the strain energy on a set of all possible lamellar orientations.
Superior outcomes of total hip arthroplasty without prior lumbar arthrodesis: a systematic review and meta-analysis
Authors: Giai Via Riccardo , Migliorini Filippo , Bosco Francesco , Onorato Francesco , Secco Davide Carlo , Giustra Fortunato , Lavia Alessandro Dario , Giachino Matteo , Massè Alessandro 
Published: October 2023

Abstract
Purpose
The number of patients undergoing total hip arthroplasty (THA) surgery after previous lumbar arthrodesis (LA) is rising. Literature suggests that LA may significantly impact pelvic biomechanics and potentially compromise the success of prosthetic hip replacement. This study aims to evaluate complication rates, dislocation rates, and revision rates in patients with prior LA undergoing THA surgery compared to those undergoing THA surgery without prior LA.

Methods
A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A PICOS template was developed to ensure a structured approach. The search for relevant studies was performed across five databases, including Pubmed, Scopus, Embase, Medline, and Cochrane. The selected articles were evaluated based on the Levels of Evidence (LoE) criteria. The Coleman Methodology Score (mCMS) was employed to analyze the retrospective studies. This systematic review and meta-analysis were registered in the International Prospective Register of Systematic Reviews (PROSPERO). For the outcomes that allowed for a meta-analysis performed using R software, a p < 0.05 was considered statistically significant.

Results
The final analysis included seventeen studies comprising a total of 3,139,164 cases of THA. Among these cases, 3,081,137 underwent THA surgery alone, while 58,027 patients underwent THA with a previous LA. The study investigated various factors, including dislocation rates, revision rates, and complication, as well as the surgical approach and type of implant used, for both the THA-only group and the group of patients who underwent THA with prior LA. The analysis revealed a statistically significant difference (p < 0.05) for all variables studied, favoring the group of patients who underwent THA alone without prior LA.

Conclusions
This systematic review and meta-analysis demonstrated a statistically significant superiority in all analyzed outcomes for patients who underwent THA-only without prior LA. Specifically, patients with isolated THA implants experienced significantly lower incidences of THA dislocation, wound complications, periprosthetic joint infection, revision, and mechanical complications.

Level of evidence
Level IV.
Family structures and parents’ occupational models: its impact on children’s diabetes
Authors: Schlarb Pauline , Büttner Janina M. , Tittel Sascha R. , Mönkemöller Kirsten , Müller-Godeffroy Esther , Boettcher Claudia , Galler Angela , Berger Gabriele , Brosig Burkhard , Holl Reinhard W. 
Published: October 2023

Abstract
Aims
This study examines how family-related factors influence the management of children and adolescents with type 1 diabetes (T1DM). We investigate the relationship between family patterns, parental work schedules and metabolic control.

Materials and methods
We analysed data from a nationwide diabetes survey (DPV) focusing on HbA1c, severe hypoglycaemia, diabetic ketoacidosis, hospital admissions and inpatient treatment duration. We used linear regression and negative binomial regression models. Our study includes 15,340 children under the age of 18 with data on family structure and parental division of labour.

Results
Children from two-parent households have better HbA1c outcomes than children from single-parent, blended or no-parent households (p < .0001). Higher HbA1C levels are associated with children living with an unemployed father, as opposed to those with full-time working parents or with a full-time working father and a part-time working mother (p < .001).

Conclusions
These findings emphasise the importance of carefully considering family structure and working time models in the management of paediatric T1DM. Our results highlight risk factors within the family environment and emphasise the need for family-focused counselling of high-risk patients or severe cases in clinical practice.
Pervasive versus situational childhood ADHD: latent classes and their clinical characteristics, based on parent and teacher ratings in a large longitudinal population sample
Authors: Frick Matilda A. , Hesser Hugo , Sonuga-Barke Edmund 
Published: October 2023

AbstractAttention-deficit/hyperactivity disorder (ADHD) diagnoses require symptoms to be present in two settings. Low levels of concordance between symptoms rated at home and school raise questions regarding this approach. The aim was to examine whether there are sub-groups with context-specific expressions of ADHD symptoms (i.e., at home or school only) with clinically significant problems sufficient to support a new diagnostic formulation. We applied latent class transition analysis to parent and teacher data (N = 10,476) from the Avon Longitudinal Study of Parents and Children (ALSPAC), collected at ages 8, 10, and 20 years. We examined the short-term stability of emergent classes and their childhood and adult-associated risk profiles. In addition to an Unaffected class (~ 45%), there was a Pervasive Combined class with elevated inattentive and hyperactive/impulsive symptoms at both home and school (~ 11%) and three classes with situational expressions; School Combined (~ 9%), Home Combined (~ 18%), and School Inattentive (~ 16%). Stability ranged from 0.27 to 0.78. The Pervasive Combined class was most symptomatic and impaired. School inattentive also displayed clinical symptom levels, whereas the School and Home Combined classes displayed subclinical levels. Different profiles regarding sex, cognition, conduct problems, and substance use emerged for the three situational classes. Distinct groupings of pervasive and situational ADHD expressions are identifiable in the general population. The isolation of a stable and burdensome Pervasive Combined class lends support to the current diagnostic approach. However, there are indications of situational expressions of ADHD with clinical symptom levels and associated difficulties.
German, Austrian, and Swiss guidelines for systemic treatment of gastric cancer
Authors: Lordick Florian , Al-Batran Salah-Eddin , Arnold Dirk , Borner Markus , Bruns Christiane J. , Eisterer Wolfgang , Faber Gerhard , Gockel Ines , Köberle Dieter , Lorenzen Sylvie , Möhler Markus , Pritzkuleit Ron , Stahl Michael , Thuss-Patience Peter , Wöll Ewald , Zander Thomas , Maschmeyer Georg ,   For the Germany Society of Hematology and Medical Oncology (DGHO, Austrian Society of Hematology and Oncology (OeGHO), Swiss Society of Hematology (SSH), Swiss Society of Medical Oncology (SGMO); in collaboration with the Arbeitsgemeinschaft Internistische Onkologie (AIO) of the German Cancer Society
Published: October 2023

AbstractThe updated edition of the German, Austrian and Swiss Guidelines for Systemic Treatment of Gastric Cancer was completed in August 2023, incorporating new evidence that emerged after publication of the previous edition. It consists of a text-based “Diagnosis” part and a “Therapy” part including recommendations and treatment algorithms. The treatment part includes a comprehensive description regarding perioperative and palliative systemic therapy for gastric cancer and summarizes recommended standard of care for surgery and endoscopic resection. The guidelines are based on a literature search and evaluation by a multidisciplinary panel of experts nominated by the hematology and oncology scientific societies of the three involved countries.
Discourses on landscape governance and transfrontier conservation areas: converging, diverging and evolving discourses with geographic contextual nuances
Authors: Mpofu Ephraim , Radinger-Peer Verena , Musakwa Walter , Penker Marianne , Gugerell Katharina 
Published: October 2023

AbstractTransfrontier conservation areas (TFCAs) are regarded as crucial instruments for biodiversity conservation as they connect landscapes across country borders. The TFCA framework is built on multi-actor, multi-sector and multi-level negotiations, a concept that incorporates principles of landscape governance (LG). This article is driven by our interest in the governance of transfrontier landscapes such as the Great Limpopo Transfrontier Park. The study aims to explore the narratives of two academic discourses of TFCA and LG. The study uses a bibliometric analysis and systematic review based on PRISMA to determine (i) to which degree the two discourses share commonalities in their narratives and take each other into account (ii) how the discourses have developed between 1998 and 2022 (iii) the geographical distribution of publications on the two discourses. Our results identified six clusters which include: African Wildlife Conservation, Governance for Biodiversity Conservation, TFCA Wildlife Connectivity, Policies and Strategies, Political Ecology, and Management of Protected Areas. The discourses depict commonalities attributed to conservation, power and actor roles. However, LG is more governance-oriented while TFCA is more skewed towards wildlife management. The TFCA discourse is a more Southern African-centred debate whilst the LG debate is more rooted in the global North resulting from unique challenges, priorities, and approaches to landscape management. Moreover, a shift from a conservation-centred approach to a more holistic social-ecological system approach is evident. By leveraging on LG and TFCA strengths, cross-fertilization can foster meaningful cross-collaborations in managing different landscapes through dialogue, knowledge sharing, and identifying common goals, challenges and opportunities.
Urban metabolism and dynamic modeling: pioneering approaches for resilient planning in the Greater Cairo Region
Authors: Younan Mina N. , El-Kholei Ahmed O. , Yassein Ghada A. 
Published: October 2023

AbstractIn Egypt, planning practice is physical and rooted in design principles, resulting in plans that seldom consider the impact of land use and land cover changes on the environment. Most used planning models are static. The paper offers urban metabolism and dynamic modeling as an alternative mode for decision making. It models population growth and expanded economic activities that characterize rapid urbanization and induce changes in land use affecting various urban economic sectors using the Greater Cairo Region (GCR) as a case study. Urban transportation contributes to climate change. The authors used secondary data and satellite images to detect land use and cover changes since 2005. After building a stock-flow diagram to describe the system’s structure, they used dynamic modeling and GIS to assess the impact of transportation on air quality. Results indicate that the population of GCR will range from 33.348 to 40.334 million in 2050. The emissions from transportation will be around 52,521.2 Gg, which is beyond the ability of the region’s ecosystems to store carbon. These findings shed doubt about the ability of GCR to reach carbon neutrality and, therefore, call for strict measures to control emitting GHGs and change in planning practices and education.
Graphical abstract