bluuebunny/crossref_metadata_2025_split huggingface dataset:
FASTKD1 is a diagnostic and prognostic biomarker for STAD associated with m6A modification and immune infiltration
Authors: Yang Yi , Gao Yan , Liu Xu-Sheng , Zhang Yu , Zhang Yao-Hua , Liu Zi-Yue , Chen Yu-Xuan , Pei Zhi-Jun 
Published: October 2023

Abstract
Background
Fas Activated Serine/Threonine Kinase Domains 1 (FASTKD1), a known modulator of mitochondrial-mediated cell death and survival processes, has garnered attention for its potential role in various biological contexts. However, its involvement in gastric cancer remains unclear. Thus, the objective of this study is to investigate the relationship between FASTKD1 expression and key factors including clinical pathologies, immune infiltration, and m6A modification in stomach adenocarcinoma (STAD).
Methods
We analyzed the expression of FASTKD1 in stomach adenocarcinoma and normal adjacent tissue to assess its significance in clinical pathologies and survival prognosis. Data from The Cancer Genome Atlas (TCGA)and Gene Expression Omnibus (GEO) databases were used in this study. Additionally, the findings were validated through immunohistochemical (IHC) staining. Co-expression analysis of FASTKD1 was performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (GO/KEGG) enrichment analysis, Gene Set Enrichment Analysis (GSEA), and LinkedOmics database. An in-depth analysis was conducted using reputable databases such as TIMER, GEPIA, and TCGA to explore the potential correlation between FASTKD1 expression and immune infiltration in STAD. Additionally, we analyzed TCGA and GEO data to explore the correlation between FASTKD1 expression levels and m6A modifications in STAD.
Results
FASTKD1 demonstrates significant upregulation across different tumor types, including STAD. Notably, it can distinguish between tumor and normal tissue samples with accuracy. The expression level of FASTKD1 correlates significantly with clinical stage and survival prognosis. Through GO/KEGG enrichment analysis, associations of FASTKD1 have been identified with nuclear chromosome segregation, chromosomal regions, catalytic activity (acting on RNA), ATPase activity, as well as cell cycle and spliceosome pathways. The GSEA analysis revealed that in STAD, FASTKD1 is linked to gene enrichment pathways, mainly including the retinoblastoma gene, activation of ATR in response to replicative stress, resolution of D-loop structures, PLK1 pathway, homologous DNA pairing and strand exchange, and nuclear pore complex disassembly. Within the TIMER, GEPIA, and TCGA databases, a notable inverse correlation has been observed between FASTKD1 expression and the abundance of immune cell subsets, such as CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells. Of particular interest, significant correlations are established between FASTKD1, and m6A modification genes YTHDF1 and LRPPRC in both TCGA and GEO datasets.
Conclusion
FASTKD1 plays a significant role in m6A modification and immune infiltration processes, making it a potential valuable diagnostic and prognostic biomarker in stomach adenocarcinoma.
Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications
Authors: Chang Andrew , Prabhala Sravya , Daneshkhah Ali , Lin Jianan , Subramanian Hariharan , Roy Hemant Kumar , Backman Vadim 
Published: October 2023

Abstract
Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~ 7–8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to identify patients who harbor CRC field carcinogenesis by evaluating chromatin 3D architecture. Supranucleosomal disordered chromatin chains (~ 5–20 nm, ~ 1 kbp) fold into chromatin packing domains (~ 100–200 nm, ~ 100–1,000 kbp). In turn, the fractal-like conformation of DNA within chromatin domains and the folding of the genome into packing domains has been shown to influence multiple facets of gene transcription, including the transcriptional plasticity of cancer cells. We deployed an optical spectroscopic nanosensing technique, chromatin-sensitive partial wave spectroscopic microscopy (csPWS), to evaluate the packing density scaling D of the chromatin chain conformation within packing domains from rectal mucosa in 256 patients with varying degrees of progression to colorectal cancer. We found average packing scaling D of chromatin domains was elevated in tumor cells, histologically normal-appearing cells 4 cm proximal to the tumor, and histologically normal-appearing rectal mucosa compared to cells from control patients (p < 0.001). Nuclear D had a robust correlation with the model of 5-year risk of CRC with r2 = 0.94. Furthermore, rectal D was evaluated as a screening biomarker for patients with advanced adenomas presenting an AUC of 0.85 and 85% sensitivity and specificity. Artificial Intelligence (AI)-enhanced csPWS improved diagnostic performance with AUC = 0.90. Considering the low sensitivity of existing CRC tests, including liquid biopsies, to early-stage cancers our work highlights the potential of chromatin biomarkers of field carcinogenesis in detecting early, significant precancerous colon lesions.
The association between uric acid and erectile dysfunction in US adults: NHANES 2001– 2004
Authors: Wang Yijun , Chen Yinghe , Fan Lailai 
Published: October 2023

Abstract
Background—
Recent evidence suggests that hyperuricemia may serve as independent risk factors for erectile dysfunction (ED), in addition to the already established factors. The exact evidence supporting this relationship is currently insufficient.
Methods and Results—
A total of 3,810 participants from the NHANES pool between 2001 and 2004 were included in our study, comprising 1,093 individuals with ED and 2,717 individuals without ED. Univariable and multivariable logistic regression analyses were performed to examine the relationship between uric acid (UA) and the prevalence of ED. In the fully adjusted model, we did not observe a significant association between UA and ED (OR = 1.02, 95% CI: 0.84–1.24), and there were no significant differences among the different UA levels (P = 0.5). In our sensitivity analyses, where we applied a stricter definition for ED, no significant results were found in the fully adjusted model (OR = 0.85, 95% CI: 0.60–1.19). Additionally, no significant differences were observed among the different UA levels (P = 0.083).
Conclusions—
Our study did not find correlation between UA levels and ED. However, further research with large sample cohorts is needed to confirm these findings.
Enriched Biscuits of Ficus Capensis Modulates Neurobehavioral Performance and Antioxidant Status of L-NAME Induced Hypertensive Rats with Anxiety-Like Behaviour
Authors: Ajeigbe Olufunke Florence , Oboh Ganiyu , Ademosun Ayokunle Olubode 
Published: October 2023

Abstract

Purpose - Anxiety and cognitive deterioration in hypertensive patients are underreported in hypertensive state. This study investigated the neuroprotective effect of Ficus capensis (FC) on cognition and anxiety-like behaviors in L-NAME-induced hypertensive male rats.
Method - Rats were administered 40 mg/kg/day L-NAME and treated with atenolol (10 mg/kg/day), diazepam (5 mg/kg/day), 2.5 g, and 5.0 g FC-enriched biscuits, respectively, (n=8) per group for 21 consecutive days. Locomotor behavior was monitored using video-tracking software for open-field tests, elevated plus maze tests, and light and dark tests, and blood pressure was measured with non-invasive tail-cuff motoring. Furthermore, acetylcholinesterase (AChE), butyl-cholinesterase (BChE), antioxidant enzyme activities in the hypothalamic and medulla brain regions, and histological staining in the hypothalamic brain section were deduced.
Results - findings from this study indicated that treatment of L-NAME-induced hypertensive rats with FC significantly (p < 0.05) ameliorated cognitive deficits and anxiety-like behavior, specifically by decreasing cumulative immobility duration in open field, rearing, latency time, and number in the dark and increasing latency time and number in the light in light and dark boxes, and zonal alterations in elevated plus maze. Additionally, FC assuaged the L-NAME-induced decrease in brain antioxidant enzyme activities and increased AChE and BChE activity and lipid peroxidation levels in the hypothalamus and medulla of hypertensive rats.
Conclusion - Taken together, FC revealed its role in reducing L-NAME-induced cognitive decline and anxiety-like behavior in hypertensive rats to be linked to its ability to restore cholinesterase enzyme activity and augment redox status. However, FC had no effect on the brain structure of L-NAME hypertensive rats.
Priority-Based Genetic Algorithm for theClustered Steiner Tree Problem
Authors: Do Tuan-Anh , Ban Ha-Bang , Le Minh Tu , Phan Duc Hung , Nguyen Thai Ha , Huynh Thi Thanh Binh 
Published: October 2023

Abstract
In a complex network connecting many devices, a set of nodes might be partitioned into multiple local clusters with different functions, properties, or communication protocols. Thus, there has been a rise in network design problems with additional constraints regarding the clustering of vertices, one of them being the Clustered Steiner Tree Problem - a variant of the Steiner Tree Problem. In the literature, there have been a few research working on this problem, but either they only solve it in a metric case, or their exploration capability is still limited. Therefore, their results are not actually good in many cases. To overcome the drawbacks, we propose a Priority-Based Genetic Algorithm to solve the Clustered Steiner Tree Problem. The proposed algorithm maintains a balance between exploration and exploitation to prevent the search from local optima. Experiments and comparisons to existing works in non-metric and metric cases are carried out deliberately to prove the remarkable performance of the proposed algorithm.
Impact of (Wood Particles (Reed) / Polypropylene) Composites on the Physical and Structural Properties
Authors: ali Raya 
Published: October 2023

Abstract
The present research focuses on the preparation of Polypropylene resin/Wood particle (reed) Composites and the study of the influence of adding the residues of natural materials on the physical and structural properties of the composite. (Polypropylene resin/Wood particle (reed) Composite has been prepared by extruding method with weight fraction (30) % and treated (reed) by sodium chloride solution (0.5). physical and structural properties which include bulk density and absorbance rate are investigated for (pure p.p), (p.p + w), (p.p.+w + silan coupling agent), (p.p.+w + Mgo),(p.p. + w + Zn(C18H35O2)2, the results illustrate enhancing in the bulk density for all samples with adding wood particles also with adding silane coupling agent, Magnesium oxide, and zinc stearate, where the maximum value of bulk density rate was for (pp + w + Mgo) composite. absorbance test was investigated by Immersion in Distilled water and Immersion in the chemical solution for all composites, the results illustrate. The weight gain of the samples after immersion is increasing compared with the sample before immersion.. AFM (Atomic Force Microscopic) for all samples was tested. It is obvious from the Topographical picture that the roughness value of wood particles reinforced polypropylene composite was high. These results indicate the features of plastic wood composites, where consider better than natural wood in terms of durability and strength of the material.
Exploring the mechanism of Chang-An-Kang on active ulcerative colitis rats based on NF-κB/STAT3 signaling pathway
Authors: Lu Zhenhua 
Published: October 2023

Abstract
Objective To investigate the therapeutic effect and mechanism of Chang-An-Kang on ulcerative colitis rats.
MethodsThe rat model of ulcerative colitis induced by 6% glacial acetic acid was established. The corresponding therapeutic drugs were given 24 hours after the model was established. The pathological morphology of colon tissue were observed after 21 days of continuous administration. The levels of interleukin-6 (IL-6) , Interleukin-7 (IL-7) , interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α) were measured by ELISA kit. The expression levels of NF-κBand STAT3 proteins in colon tissue were detected by IHC.
ResultsThe results showed that the changes of the pathological and biochemical indexes of the rat colon tissue indicate that the model was successfully established. Chang-An-Kang could significantly improved the rat colon tissue damage, decrease the content of IL-6, IL-7 and TNF-α, and increase the content of Il-10. The NF-κB and STAT3 proteins expression levels were decreased.
Conclusion By increasing the content of anti-inflammatory factor IL-10, decreasing the content of pro-inflammatory factors IL-6 and TNF-α, and inhibiting the expression of NF-κB and STAT3 proteins, Chang-An-Kangcan reduce inflammatory infiltration. It has a obvious therapeutic effect on acetic acid ulcerative colitis in rats.
Weight development in a northern island population of water voles Arvicola amphibius: approaching an optimal weight to survive the winter?
Authors: Frafjord Karl 
Published: October 2023

Abstract
Abstract
Background: Growth and body size of mammals are commonly correlated with many life history strategies, including those related to survival and reproduction. However, in certain circumstances suboptimal growth rates and smaller size may be advantageous and adaptive. The water vole Arvicola amphibius is a large vole, about three times the size of a field vole Microtus agrestis, but with similar ecological and reproductive characteristics. Island populations were studied on the coast of northern Norway, just below the Arctic Circle, during 2003-2018, by capture-mark-recapture. The main aims were to study growth rates, asymptotic weight and survival, expecting that the “optimal” weight for surviving the winter would be 140-160 g.
Results: The smallest juveniles caught weighed only 21 g and were assumed, based on data from the literature, to be around 14 days old. This age was used as starting point for the growth curve. This, however, may have been about one week too early, as juveniles are more likely not fully weaned and leave their nest of birth until 30-40 g. Initial growth rates in juveniles was relatively high but declined from around 100-120 g or 40-50 days old. The asymptotic weight was not clearly defined, but its maximum was around 150-160 g. Most juveniles that survived the winter weighed between 100 and 160 g in their first summer. Large individual variations in growth rates were found. Overwintered subadults in spring weighed about the same as juveniles did in the autumn but grew quickly in April and May to reach adult size.
Conclusions: A specific “optimal” weight for juveniles that survived the winter was not found. The range could be given as 100-160 g, too broad to define an “optimal” weight range. However, those that survived tended to be slightly heavier than those that died. Reproducing adults generally weighed 180-220 g and did not reduce their weight toward the autumn, i.e., to increase winter survival, but very few adults survived even the summer and almost none survived their second winter. Juveniles postponed reproduction until next spring, most likely to take advantage of fresh vegetation growth and less competition.
Fast Improvements of Acute Inflammatory Symptomatology in Patients With Hand Osteoarthritis With the Use of Doxycycline.
Authors: DE AZEVEDO MARIO NEWTON LEITAO , Arnez Marco Antonio Cullar , Moss Ingrid Bandeira , Bianchi Breno Valdetaro , Bica Blance Elena Rios Gomes 
Published: October 2023

Abstract
Background: Osteoarthritis (OA) presents the high activity of free radicals and proteolytic enzymes which were inhibited by Doxycycline (DOX).
Objective: To search the efficacy, safety, and fastness for the improvement of inflammatory signs in patients with Hand Osteoarthritis (HOA).
Methodology: Randomized, placebo-controlled trial during four weeks with two groups of patients: DOX group using one tablet of 100 mg bid per os; control group using paracetamol bid per os; the data were obtained through Visual Analog Scale (VAS) evaluation for pain, flushing/edema by the patient and the examiner; the primary outcome was the improvement greater than 50% from the basal values after four weeks.
Results: Thirty-eight female patients with HOA after menopause were allocated: 20 in the DOX group and 18 in the control group. The results showed that the DOX group presented a significant improvement in 75% of patients compared to the control group (p <0.00000), which started after 6.05 ± 3.7 days of treatment; and mild adverse effects in 20% of the sample - gastric pain, nausea, vomiting after 9.0 ± 5.2 days without any removal from the trial. Compared to the baseline and the control group results, was observed a significant improvement in pain (p <0.00000) and edema/flushing (p<0.00000) demonstrated the efficacy of inflammation; no abnormality was seen on the blood analysis, and no hematological, renal, cardiologic and hepatic commitment.
Conclusion: Doxycycline by a short length of time was safe and improved the pain and inflammatory signs of HOA.
AL-QUR’AN SEBAGAI OBJEK KAJIAN STUDI AGAMA ISLAM
Authors: Fauzi M. Ihsan 
Published: October 2023

Agama berperan penting sebagai pencetak watak dan moral dalam kehidupan manusia, juga sebagai pencetus sebuah pemikiran masyarakat. Agama hadir sebagai alat penghubung antara manusia dengan penciptanya dan al-Qur’an sebagai dasar landasannya. Artikel ini mengkaji tentang al-Qur’an sebagai objek kajian studi agama Islam dengan beberapa metode pendekatan. Metode yang digunakan dalam penelitian ini adalah studi pustaka. Berdasar penelitian ditemukan bahwa dalam pendekatan normatif, agama merupakan dasar yang murni berasal dari Tuhan yang belum tercampur dengan nalar pikiran manusia. Di dalamnya mengkaji tekstual al-Qur’an yang menjelaskan arti norma dan pokok penting yang terkandung di dalamnya. Adapun pendekatan sosiologi itu lebih condong kepada kajian tentang kehidupan masyarakat, baik itu hubungan antar individu maupun hubungan secara berkelompok. Dalam pendekatan ini yang menjadi fokus utama adalah hubungan sosial masyarakat. Adapun untuk pendekatan antropologi itu merupakan kajian yang membahas tentang sejarah perkembangan manusia. Dimana budaya, ras dan bahasa menjadi titik berat kajian dalam pendekatan tersebut. Pendekatan sosiologi dan antropologi memiliki relasi pada kajian living Qur’an. Keduanya memiliki hubungan dalam konteks budaya dan sosial dalam melihat bagaimana masyarakat menyikapi dan merespon al-Qur’an dikehidupan mereka sehari-hari.
REVIEW OF PURCHASING AND SELLING NFTS IN ISTIHSAN
Authors: Fad Mohammad Farid 
Published: October 2023

AbstractSo far, NFTs have been defined as digital tokens that are shaped like ownership certificates for virtual and physical assets. These NFTs are usually traded online and are often paid for using cryptocurrencies, especially Ethereum. However, the problem is that in 2021 the MUI issued a fatwa that cryptocurrency is illegal. This is because it there are elements of qimar, dharar, and gharar. For this reason, it is necessary to study the methodology of Islamic law regarding Non-Fungible Tokens (NFT) through istihsan (juristic preference). This study uses a qualitative approach. The data were collected from library study, documentation and observation. In analyzing the data used descriptive-analytic analysis with the approach used is ushuliyah. This study revealed that from istihsan point of view, transactions using Non-Fungible Tokens are permitted. This is because, from Qiyas Khafi perspective, NFT is known as the underlying assets of the transaction. Up to the operational level, if qiyas khafi is of greater benefit, then qiyas jali may be abandoned. What is used is qiyas khafi to maintain the principles of maqasid shari'a. Therefore, within the istihsan framework, Non-Fungible Token transactions are allowed through qiyas khafi due to an element of greater benefit.Keywords: Non-Fungible Token Transaction; Istihsan; Maqasid Shari’a, AbstrakSelama ini NFT didefinisikan sebagai token digital yang berbentuk seperti sertifikat kepemilikan untuk aset virtual dan fisik. NFT ini adalah biasanya diperdagangkan secara online dan sering dibayar untuk menggunakan cryptocurrency, khususnya Ethereum. Namun yang menjadi persoalan ialah pada tahun 2021 MUI pernah memfatwakan haram penggunaan cryptocurrency karena mengandung unsur gharar, dharar, dan qimar. Untuk itu, diperlukan kajian metodologi hukum Islam tentang Non-Fungible Token (NFT) melalui istihsan. Penelitian ini menggunakan pendekatan kualitatif. Sementara metode pengumpulan data yang dipakai dalam penelitian ini adalah metode literatur, dokumentasi dan observasi. Dalam menganalisis data yang telah dikumpulkan, peneliti menggunakan analisis deskriptif-analitis dengan pendekatan ushuliyah. Hasil penelitian ini menyatakan bahwa dalam tinjauan istihsan, transaksi dengan menggunakan Non-Fungible Token diperbolehkan. Hal ini dikarenakan dalam tinjauan qiyas khafi, NFT dikenal asset yang mendasari transaksi tersebut (underlying assets). Hingga dalam tataran operasionalnya, bila qiyas khafy lebih besar manfaatnya, maka qiyas jaly itu boleh ditinggalkan dan yang dipakai adalah qiyas khafy demi terpeliharanya prinsip-prinsip maqasid syari’ah. Oleh karena itu, dalam kerangka istihsan, transaksi Non-Fungible Token diperbolehkan melalui qiyas khafi dikarenakan adanya unsur maslahat yang lebih besar.Keywords: Non-Fungible Token; Istihsan; Maqashid Syari’ah.
AKURASI ARAH KIBLAT MASJID KUNO AL-ABROR BANDAR LAMPUNG DENGAN METODE RASHDUL KIBLAT HARIAN
Authors: Khairunnisa Ariba , Aryani Dian Ika 
Published: October 2023

Masjid Al-Abror adalah salah satu masjid kuno yang didirikan pada tahun 1914. Arah kiblat masjid ini dijadikan rujukan bagi masyarakat sekitar yang akan membangun masjid baru sehingga arah kibatnya harus akurat. Namun hal ini menjadi masalah ketika masjid Al-Abror sendiri arah kiblatnya melenceng. Untuk itu diperlukan penelitian lebih lanjut mengenai keakurasian arah kiblat pada masjid ini dan juga pandangan para jamaah masjid terhadap adanya rekonstruksi tersebut. Penelitian ini menggunakan metode penelitian lapangan untuk mengecek akurasi arah kiblat masjid dan metode wawancara kepada jamaah masjid untuk megetahui respon mereka terhadap rekonstruksi akurasi arah kiblat. Penulis melakukan pengecekan arah kiblat Masjid Al-Abror menggunakan metode rashdul kiblat harian dan metode theodolite dengan perhitungan azimuth kiblat dengan data ephemeris yang diterbitkan oleh Departemen Agama RI. Hasil dari perhitungan azimuth kiblat ini kemudian dikalibrasikan dengan rashdul kiblat harian. Dari hasil perhitungan dan analisa membuktikan bahwa Masjid Al-Abror mengalami kemelencengan sebesar 10o 50’ 38,63” kurang ke utara. Kedua metode menunjukkan bahwa masjid Al-Abror berada di azimuth 284o 27’ 2.75” UTSB yang seharusnya bernilai 295o 17’ 41.38”. Hasil wawancara dengan pengurus dan jamaah masjid adalah bahwa mereka menerima hasil penelitian dan mempertimbangkan untuk mengubah arah kiblatnya dengan hasil pengukuran setelah dilakukan musyawarah.