bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elbow dislocation approach for complex elbow fractures: a cadaveric study
Authors: Liu Yang , Gao Yuling , Xu Xiaopei , Zhao Yanrui , Wang Hanzhou , Sun Qingnan , Zhao Binzhi , Wang Siyuan , Zhou Junlin 
Published: December 2023

AbstractBackgroundApproach need to be considered when surgeons dealt with complex elbow injuries and the choice of the approach is a challenge for surgeons due to the complex anatomy. On the basis of releasing the lateral collateral ligament, we modified the dislocation technique to pursue the superior exposure including not only the distal humeral surface but also the anterior facet of the coronoid process.MethodsA total of 4 cadaver specimens and 8 elbows were included in the study. Each cadaver provided one elbow for either the elbow dislocation approach or the posterior olecranon approach. The exposed distal articular surface of humerus, humeral capitulum, humeral trochlea, anterior trochlea of distal humerus, posterior trochlea of distal humerus and the ulnar coronoid process surface were marked by image J software and calculated for a comparison for each surgical approach.ResultsThe total distal humeral surface was exposed as a median of 98.2 (97.6, 99.6)% and 62.0 (58.3, 64.5)% for the elbow dislocation approach and the olecranon osteotomy approach (P < 0.001), the capitulum 100% and 32.4 (28.0, 39.2)% (P < 0.001), the trochlea 93.2(90.1, 96.9)% and 72.5 (65.2, 78.8)% (P < 0.001), the anterior trochlear articular surface 96.0(93.0, 97.4)% and 50.3 (43.6, 59.1)% (P < 0.001), the posterior trochlear articular surface 95.4 (93, 100)% and 100% (P = 0.76) and the articular surface of the coronoid process of ulna 71.3 (66.0, 74.2)% and 0% (P < 0.001).ConclusionFor complex elbow fractures, the technique of elbow dislocation provides complete exposure of the distal humerus surface and a significant portion of the coronoid process surface, facilitating direct visualization for reduction and fixation.Level of evidenceAnatomy Study; Cadaver Dissection.
Automated and app-based activation of first responders for prehospital cardiac arrest: an analysis of 16.500 activations of the KATRETTER system in Berlin
Authors: Pommerenke C. , Poloczek S. , Breuer F. , Wolff J. , Dahmen J. 
Published: December 2023

Abstract
Background
Bystander CPR is one of the main independent factors contributing to better survival after out-of-hospital cardiac arrest. Simultaneously, the rate of bystander CPR in Germany is below the European average. First responder applications (apps) contribute to reducing the time period without CPR (no-flow time) until professional help can arrive on-scene.

Methods
The KATRETTER app was introduced in Berlin as one of the first apps in Europe which do not require any medical qualifications to register as a first responder. The activation of volunteer first responders for suspected cardiac arrest cases through the Berlin Emergency Medical Services integrated control center was evaluated based on data collected between 16 Oct 2020 and 16 Oct 2022. Our descriptive analysis includes the number of registered first responders, number of activations, the number and percentages of accepted activations, as well as all reports where first responders arrived at the scene.

Results
As of 15 Oct 2022, a total of 10,102 first responders were registered in the state of Berlin. During this specified period, there were 16.505 activations of the system for suspected out-of-hospital cardiac arrest. In 38.4% of the accepted cases, first responders documented patient contact, and in 34.6% of cases with patient contact, CPR was performed. Only 2% of registered first responders did not have any medical qualifications.

Conclusions
Smartphone-based first responder applications should not be understood as a means of alerting professional help, but rather like a digitally amplified “call for help” in the vicinity of an emergency location. A large number of first responders can be recruited within 24 months, without large-scale public relations work necessary. No qualifications were required to become a first responder, contributing to a low-threshold registration process with the effect of a more widespread distribution of the app and cost reduction during implementation.
RAPIDIRON Trial follow-up study — the RAPIDIRON-KIDS Study: protocol of a prospective observational follow-up study
Authors: Derman Richard J. , Bellad Roopa B. , Bellad Mrutyunjaya B. , Bradford-Rogers Jesse , Georgieff Michael K. , Aghai Zubair H. , Thind Simal , Auerbach Michael , Boelig Rupsa , Leiby Benjamin E. , Short Vanessa , Yogeshkumar S. , Charantimath Umesh S. , Somannavar Manjunath S. , Mallapur Ashalata A. , Pol Ramesh , Ramadurg Umesh , Sangavi Radha , Peerapur Basavaraj V. , Banu Nasima , Patil Praveen S. , Patil Amaresh P. , Roy Subarna , Vastrad Phaniraj , Wallace Dennis , Shah Hemang , Goudar Shivaprasad S. 
Published: December 2023

Abstract
Background
Anemia is a worldwide problem with iron deficiency being the most common cause. When anemia occurs in pregnancy, it increases the risk of adverse maternal, fetal, and postnatal outcomes. It induces preterm births and low birth weight (LBW) deliveries, long-term neurodevelopmental sequelae, and an increased risk of earlier onset of postnatal iron deficiency. Anemia rates are among the highest in South Asia, and India’s National Family Health Survey (NFHS-5) for 2019–2021 indicated that over half of pregnant women, and more than 65% of children, in the country are classified as anemic (Sciences IIfP, National Family Health Survey-5, 2019–21, India Fact Sheet). In 2021, the parent RAPIDIRON Trial (Derman et al., Trials 22:649, 2021) was initiated in two states in India, with the goal of assessing whether a dose of intravenous (IV) iron given to anemic women during early pregnancy results in a greater proportion of participants with normal hemoglobin concentrations in the third trimester and a lower proportion of participants with LBW deliveries compared to oral iron. As a follow-up to the RAPIDIRON Trial, the RAPIDIRON-KIDS Study will follow the offspring of previously randomized mothers to assess, neurobehavioral, hematological, and health outcomes.

Methods
This prospective observational cohort study will follow a subset of participants previously randomized as part of the RAPIDIRON Trial and their newborns. Study visits occur at birth, 6 weeks, 4 months, 12 months, 24 months, and 36 months and include blood sample collection with both maternal and infant participants and specific neurobehavioral assessments conducted with the infants (depending on the study visit). The primary outcomes of interest are (1) infant iron status as indicated by both hemoglobin and ferritin (a) at birth and (b) at 4 months of age and (2) the developmental quotient (DQ) for the cognitive domain of the Bayley Scales of Infant Development Version IV (BSID-IV) at 24 months of age.

Discussion
This RAPIDIRON-KIDS Study builds upon its parent RAPIDIRON Trial by following a subset of the previously randomized participants and their offspring through the first 3 years of life to assess neurodevelopmental and neurobehavioral (infants, children), hematological, and health outcomes.

Trial registration
ClinicalTrials.gov NCT05504863, Registered on 17 August 2022. Clinical Trials Registry – India CTRI/2022/05/042933. Registered on 31 May 2022.
Accidental portal vein catheterization during pleural drainage catheter insertion: a case report
Authors: Zoghoul Sohaib , Al‑Hashimi Israa , Aldebyani Qayed , Kassamali Rahil , Omar Ahmed , Barah Ali 
Published: December 2023

Abstract
Background
Iatrogenic portal vein (PV) injuries following pleural drainage catheter (PDC) insertion are rare but life-threatening. This case report emphasizes the importance of prompt recognition and effective interventional radiology (IR) management.

Case presentation
A 38-year-old Asian male, admitted for a non-ST-segment elevation myocardial infarction, suffered a critical PV injury during PDC insertion, leading to rapid clinical deterioration. The IR team conducted a portogram, retrieved the catheter, and successfully executed an embolization procedure. The patient's recovery, confirmed through imaging and improving liver function tests, enabled discharge with follow-up instructions.

Conclusions
This case highlights the clinical significance of promptly recognizing and effectively managing iatrogenic PV injuries during PDC insertion, with the pivotal role of IR. Collaboration between IR and surgical teams is crucial for optimizing patient outcomes.
Rogue wave patterns of the Fokas-Lenells equation
Authors: Yan Xue-Wei , Chen Yong 
Published: December 2023

Abstract
In this work, we study the high-order rogue wave solution for the Fokas-Lenells equation using the Kadomtsev-Petviashvili (KP) reduction method. These rogue wave patterns consist of triangle, pentagon, heptagon, nonagon, which are analytically described by the root structures of the Yablonskii-Vorob'ev polynomial hierarchy. On the other hand, we also report the other types of rogue wave patterns including heart-shaped, fan-shaped, two-arc+triangle, arc+pentagon, etc., which are analytically described by the root structures of Adler-Moser polynomials. These polynomials are the generalizations of the Yablonskii-Vorob'ev polynomial hierarchy, because of the arbitrariness of complex parameter

. In addition, these rogue wave patterns are formed by the Peregrine solitons undergoing dilation, rotation, stretch, shear and translation. We also compare the prediction solutions with the corresponding true solutions and show the good consistency between them.
Proteoglycan inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification
Authors: Koosha Elham , Brenna Connor T. A. , Ashique Amir M. , Jain Niteesh , Ovens Katie , Koike Toshiyasu , Kitagawa Hiroshi , Eames B. Frank 
Published: December 2023

ABSTRACT
During endochondral ossification, chondrocytes secrete a proteoglycan (PG)-rich extracellular matrix that can inhibit the process of cartilage maturation, including expression of Ihh and Col10a1. Because bone morphogenetic proteins (BMPs) can promote cartilage maturation, we hypothesized that cartilage PGs normally inhibit BMP signalling. Accordingly, BMP signalling was evaluated in chondrocytes of wild-type and PG mutant (fam20b−/−) zebrafish and inhibited with temporal control using the drug DMH1 or an inducible dominant-negative BMP receptor transgene (dnBMPR). Compared with wild type, phospho-Smad1/5/9, but not phospho-p38, was increased in fam20b−/− chondrocytes, but only after they secreted PGs. Phospho-Smad1/5/9 was decreased in DMH1-treated or dnBMPR-activated wild-type chondrocytes, and DMH1 also decreased phospho-p38 levels. ihha and col10a1a were decreased in DMH1-treated or dnBMPR-activated chondrocytes, and less perichondral bone formed. Finally, early ihha and col10a1a expression and early perichondral bone formation of fam20b mutants were rescued with DMH1 treatment or dnBMPR activation. Therefore, PG inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification, and these results offer hope for the development of growth factor therapies for skeletal defects of PG diseases.
Dual Bounds from Decision Diagram-Based Route Relaxations: An Application to Truck-Drone Routing
Authors: Tang Ziye , van Hoeve Willem-Jan 
Published: December 2023

For vehicle routing problems, strong dual bounds on the optimal value are needed to develop scalable exact algorithms as well as to evaluate the performance of heuristics. In this work, we propose an iterative algorithm to compute dual bounds motivated by connections between decision diagrams and dynamic programming models used for pricing in branch-and-cut-and-price algorithms. We apply techniques from the decision diagram literature to generate and strengthen novel route relaxations for obtaining dual bounds without using column generation. Our approach is generic and can be applied to various vehicle routing problems in which corresponding dynamic programming models are available. We apply our framework to the traveling salesman with drone problem and show that it produces dual bounds competitive to those from the state of the art. Applied to larger problem instances in which the state-of-the-art approach does not scale, our method outperforms other bounding techniques from the literature. Funding: This work was supported by the National Science Foundation [Grant 1918102] and the Office of Naval Research [Grants N00014-18-1-2129 and N00014-21-1-2240]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2021.0170 .
Validation of the Observer-Reported Communication Ability (ORCA) Measure for Individuals With Angelman Syndrome
Authors: Zigler Christina K. , Lin Li , McFatrich Molly , Lucas Nicole , Gordon Kelly L. , Jones Harrison N. , Berent Allyson , Panagoulias Jennifer , Evans Paula , Reeve Bryce B. 
Published: December 2023

Abstract
There is a critical need for high-quality clinical outcome assessments to capture the important aspects of communication ability of individuals with Angelman syndrome (AS). To center the perspective of caregivers, our team developed the novel Observer-Reported Communication Ability (ORCA) measure using best practice guidelines, with the goal of developing a measure that could be administered to caregivers directly without the need for a certified administrator for use in clinical trials. To refine the draft measure, we conducted two rounds of cognitive interviews with 24 caregivers and a quantitative study including 249 caregivers. The results from both studies support the overall content validity, construct validity, and the reliability of the ORCA measure for individuals with AS &gt; 2 years old for use in research contexts. Future work should explore the responsiveness of ORCA measures to changes over time in a diverse sample.
Integrating health belief model and theory of planned behavior to assess COVID-19 vaccine acceptance among urban slum people in Bangladesh
Authors: Patwary Muhammad Mainuddin , Disha Asma Safia , Hasan Mahadi , Bardhan Mondira , Hasan Mehedi , Tuhi Faiza Imam , Rahim Sama Jamila , Newaz Md. Navid , Imran Sardar Al , Haque Md. Zahidul , Hossain Md. Riad , Kabir Md Pervez , Swed Sarya 
Published: December 2023

Introduction
The vaccination against coronavirus disease 2019 (COVID-19) has been identified as a promising strategy to reduce the severity of the pandemic. Despite the safe and effective COVID-19 vaccines, bringing socioeconomically disadvantaged people under vaccination coverage has been challenging for developing countries like Bangladesh. Therefore, this study explored the determinants of vaccine acceptance among urban slum residents of Bangladesh using the Health Belief Model (HBM) and Theory of Planned Behavior (TPB).

Methods
A face-to-face survey of 400 urban slum dwellers in two large cities in Bangladesh was conducted between July 5 to August 5, 2021. The questionnaire included vaccine acceptance, socio-demographics, health-related characteristics, trust in health authorities, reasons for vaccine hesitancy, and dimensions of HBM and TPB frameworks. Hierarchical logistic regression was performed to evaluate the association between these characteristics and vaccination acceptance.

Results
Around 82% (n = 327) of respondents were willing to accept the COVID-19 vaccine. In a fully adjusted model, respondents with secondary level education had higher intention (OR = 46.93, 95%CI = 1.21–1807.90, p < 0. 05) to accept COVID-19 vaccine. Respondents with bad (OR = 0.11, 95%CI = 0.01–0.35, p<0.05) or very bad (OR = 0.01, 95%CI = 0.01–0.35, p<0.05) health conditions were less interested in the COVID-19 vaccination. In regard to HBM dimensions, greater perceived susceptibility (OR = 1.75, 95% CI = 1.12–2.75, p < 0.05), and perceived benefits (OR = 3.28, 95% CI = 1.17–6.00, p < 0.001) were associated with a greater willingness to get vaccinated. In regard to TPB, higher self-efficacy in preventing illness without the vaccine increased the desire to get vaccinated (OR = 1.55, 95% CI = 1.02–2.37, p < 0.05). Fear of unknown side effects, religious beliefs, contraindications to vaccination, and insufficient information on the vaccine were the main reasons for vaccine hesitancy.

Conclusions
These findings offer valuable insights for policymakers in Bangladesh to design targeted interventions that address vaccine hesitancy and increase vaccination acceptability among socially disadvantaged individuals in urban areas. Strategies should focus on providing accurate and accessible information about the vaccine, communicating its positive impact effectively, engaging with religious leaders to address misconceptions, and tailoring vaccination campaigns to meet the unique needs of different demographic groups.
Transferrin receptor in primary and metastatic breast cancer: Evaluation of expression and experimental modulation to improve molecular targeting
Authors: Fontana Francesca , Esser Alison K. , Egbulefu Christopher , Karmakar Partha , Su Xinming , Allen John S. , Xu Yalin , Davis Jennifer L. , Gabay Ariel , Xiang Jingyu , Kwakwa Kristin A. , Manion Brad , Bakewell Suzanne , Li Shunqiang , Park Haeseong , Lanza Gregory M. , Achilefu Samuel , Weilbaecher Katherine N. 
Published: December 2023

Background
Conjugation of transferrin (Tf) to imaging or nanotherapeutic agents is a promising strategy to target breast cancer. Since the efficacy of these biomaterials often depends on the overexpression of the targeted receptor, we set out to survey expression of transferrin receptor (TfR) in primary and metastatic breast cancer samples, including metastases and relapse, and investigate its modulation in experimental models.

Methods
Gene expression was investigated by datamining in twelve publicly-available datasets. Dedicated Tissue microarrays (TMAs) were generated to evaluate matched primary and bone metastases as well as and pre and post chemotherapy tumors from the same patient. TMA were stained with the FDA-approved MRQ-48 antibody against TfR and graded by staining intensity (H-score). Patient-derived xenografts (PDX) and isogenic metastatic mouse models were used to study in vivo TfR expression and uptake of transferrin.

Results
TFRC gene and protein expression were high in breast cancer of all subtypes and stages, and in 60–85% of bone metastases. TfR was detectable after neoadjuvant chemotherapy, albeit with some variability. Fluorophore-conjugated transferrin iron chelator deferoxamine (DFO) enhanced TfR uptake in human breast cancer cells in vitro and proved transferrin localization at metastatic sites and correlation of tumor burden relative to untreated tumor mice.

Conclusions
TfR is expressed in breast cancer, primary, metastatic, and after neoadjuvant chemotherapy. Variability in expression of TfR suggests that evaluation of the expression of TfR in individual patients could identify the best candidates for targeting. Further, systemic iron chelation with DFO may upregulate receptor expression and improve uptake of therapeutics or tracers that use transferrin as a homing ligand.
Association between systolic blood pressure and low-density lipoprotein cholesterol with coronary heart disease according to age
Authors: Wang Nelson , Mustafa Rima , Zuber Verena , Rodgers Anthony , Dehghan Abbas 
Published: December 2023

Background
The impact of elevated systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart disease (CHD) at different stages of life is unclear. We aimed to investigate whether genetically mediated SBP/LDL-C is associated with the risk of CHD throughout life.

Methods and findings
We conducted a three-sample Mendelian randomization analysis using data from the UK Biobank including 136,648 participants for LDL-C, 135,431 participants for SBP, and 24,052 cases for CHD to assess the effect of duration of exposure to the risk factors on risk of CHD. Analyses were stratified by age at enrolment. In univariable analyses, there was a consistent association between exposure to higher LDL-C and SBP with increased odds of incident CHD in individuals aged ≤55 years, ≤60 years, and ≤65 years (p-value for heterogeneity = 1.00 for LDL-C and 0.67 for SBP, respectively). In multivariable Mendelian randomization analyses, exposure to elevated LDL-C/SBP early in life (age ≤55 years) was associated with a higher risk of CHD independent of later life levels (age >55 years) (odds ratio 1.68, 95% CI 1.20–2.34 per 1 mmol/L LDL-C, and odds ratio 1.33, 95% CI 1.18–1.51 per 10 mmHg SBP).

Conclusions
Genetically predicted SBP and LDL-C increase the risk of CHD independent of age. Elevated SBP and LDL-C in early to middle life is associated with increased CHD risk independent of later-life SBP and LDL-C levels. These findings support the importance of lifelong risk factor control in young individuals, whose risk of CHD accumulates throughout life.
Cyp3A4 *1G polymorphism is associated with alcohol drinking: A 5-year retrospective single centered population-based study in China
Authors: Jia Xiaoqing , Zhang Xiaoting , Zhou Tao , Sun Dalong , Li Rong , Yang Na , Luo Zheng 
Published: December 2023

Introduction
We investigated the epidemiology of Cytochrome P450 (CYP) 3A4 genotype and the relationship between CYP3A4 genotype and alcohol drinking habits.

Materials and methods
A single-centered retrospective study was conducted on 630 patients who underwent CYP3A4*1G genetic testing. Their relevant information on epidemiology and etiology was collected. Laboratory testing, including CYP3A4*1G genotype, liver function tests, and serum lipid measurements were performed. Bi-variate logistic regressions were used to examine the relationship between variables. The relationship between alcohol drinking and CYP3A4*1G genotype was estimated. Demographic and clinical features were analyzed. Participants with drinking history were divided into non-heavy drinking and heavy drinking groups. Liver function and dyslipidemia of participants with drinking histories were compared between CYP3A4*1G mutation (GA+AA) and wild-type (GG) groups.

Results
Participants with CYP3A4*1G mutation(GA+AA) had an increased adjusted odds ratio (AOR) of 2.56 (95% CI, 1.4–4.65; P = 0.00) for alcohol abuse when compared with participants without CYP3A4 mutation (GG). In the subgroup of participants with alcohol abuse, there are no significant differences in liver injury levels and serum lipid levels between CYP3A4*1G mutant and wild-type groups. Patients with CYP3A4*1G mutation had an increased AOR of cardiac-vascular diseases and malignant diseases compared with patients without CYP3A4*1G mutation. The epidemiology had no difference between GA and AA group.

Conclusion
The study indicated that there was association between alcohol drinking and CYP3A4*1G genetic mutation. In the subgroup of participants with alcohol abuse, there are no significant differences in liver injury and dyslipidemia between CYP3A4*1G mutant and wild-type groups. CYP3A4*1G mutation was also related to cardiac-vascular diseases and malignant diseases.