bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationships between student content-specific grouping and teachers-students’ interactions during online collaborative mathematical task solving
Authors: Olsher Shai , Abdu Rotem , Shalata Mohamed 
Published: January 2025

Abstract
We examined the relationships between student content-specific grouping and the attributes of teachers-students’ interactions during online collaborative mathematical task solving using a learning analytics tool for automatic formative assessment. Such technology offloads some teachers’ responsibilities regarding mathematical aspects of learning, and we therefore ask, what are the characteristics of teachers’ interactions with students in this context? How do these characteristics relate to content-specific grouping? We examined teachers’ interactions with 29 pairs of 10th-grade students in distance group mathematics learning in a technological environment on the subject of the quadratic function. Students were teamed according to their work on a preliminary task in one of the following ways: encompassing, mutual, or similar. Quantitative and qualitative analyses of teachers’ interactions with students and interviews were conducted. We identified four categories of teacher actions that characterize dialog facilitation: task comprehension, technology use, mathematics content, and interpersonal interactions. The findings showed that teachers initiated more inferences than students in the interpersonal and task comprehension categories, while there was no significant difference between the initiators of the other categories. Furthermore, teachers and students initiated interpersonal interactions significantly more when groups were grouped with unbalanced relationships (encompassing, commonly known as heterogeneous grouping). These findings shed light on the potential to foster nuanced abilities of mathematics teachers to facilitate group work.
Global interfertility and heterosis in sugar kelp populations: a next step in sugar kelp breeding
Authors: Cohen Job , Twijnstra Robert , Schiller Jessica , Montecinos Arismendi Gabriel , Reus Brigit , Soetaert Karline , Timmermans Klaas 
Published: January 2025

Abstract
The potential of seaweed aquaculture is restricted by high labor, production and processing costs, leading to low economic viability. Selective breeding can improve yields and cultivation efficiency, thereby decreasing production costs. Until now, genetic resources as input for Saccharina latissima breeding trials have been sourced strictly locally, due to concerns regarding outplanting genetically exogenous material in local waters. Here we study, for the first time, worldwide interregional fertility of the seaweed S. latissima, in order to assess the potential of including global S. latissima genetic resources for selective breeding with regard to heterosis. We quantified the yield (as an indicative aquacultural performance) and morphological traits of intra- and interregional S. latissima hybrids originating from a broad range of locations in a common garden experiment. Our results show that the practical application of worldwide S. latissima genetic resources in breeding programs is feasible based on global interfertility. We found a wide morphological diversity of hybrids and observed significant heterosis in interregional hybrids. The degree of heterosis could not be linked to geographic distance. These findings reveal that worldwide genetic resources can considerably contribute to S. latissima breeding programs and could offer a major next step in improving yields and quality traits.
Pharmacokinetics of Nivolumab and Erythropoietin in a Rat Model of Diet-Induced Obesity
Authors: Sheng Yi-Hua , Park Celine , Chong Yae Eun , Yohn Christine , Siemiątkowska Anna , Kosicka-Noworzyń Katarzyna , Kaur Amrit , Sapra Karan , Brunetti Luigi , Kagan Leonid 
Published: January 2025

Abstract

Purpose
To investigate how obesity affects the pharmacokinetics of biologics in a rat model.

Method
Male Long-Evans rats were fed a high-fat diet from the age of 3 weeks and development of obesity was monitored by measuring body size and composition (fat and lean mass). The animals received nivolumab (1 and 8 mg/kg) or recombinant human erythropoietin (rHuEPO, 1000 IU/kg) by intravenous or subcutaneous injection. Serum samples were collected and analyzed using an enzyme-linked immunosorbent assay (ELISA). Endogenous rat IgG was also measured in the nivolumab study. A standard noncompartmental analysis was performed to calculate pharmacokinetic parameters.

Results
When dosed at mg/kg of total body weight approach, no significant differences in pharmacokinetics of nivolumab and rHuEPO between lean and obese cohorts were observed despite significant differences in the body composition. Subcutaneous bioavailability of nivolumab was inversely dependent on the dose level.

Conclusions
Pharmacokinetic parameters of two biologics tested in this work were not affected by obesity, and mg/kg dosing approach was necessary to achieve equivalent exposure in serum. The results were different from our previous findings of significant effect of obesity on pharmacokinetics of human IgG in rats. Additional studies with other biologics are urgently needed in preclinical and clinical settings.
Pathway from Earthquake Fear to Post-Traumatic Growth: The Roles of Resilience, Self-Efficacy, and Positive Childhood Memories Among Survivors of the 2023 Türkiye Earthquakes
Authors: İme Yakup , Kama Rumeysa Hoşoğlu , Arslan Nihan Çitemel 
Published: January 2025

Abstract
Posttraumatic growth is essential for understanding how individuals process trauma and adapt psychologically in the aftermath of seismic events. This study aims to explore the mediating effects of resilience, self-efficacy, and positive childhood memories on the relationship between fear of earthquakes and post-traumatic growth among survivors of the 2023 Türkiye earthquake (N = 423). The results of a multi-mediation analysis indicated that earthquake fear indirectly influenced post-traumatic growth through resilience, self-efficacy, and positive childhood memories. Consequently, these factors may serve as protective mechanisms promoting post-traumatic growth in earthquake survivors. Implementing strategies to enhance resilience and self-efficacy, as well as fostering positive childhood memories, may be essential for mitigating the adverse effects associated with earthquakes.
Physicochemical and Spatial Distributions of Trace Elements and Organochlorine Compounds in Lake Idku Water, Egypt
Authors: Osman Khaled A. , Elgendy Sara M. , Ibrahim Hesham Z. 
Published: January 2025

Abstract
This study aimed to characterize the water quality of 4 sites in Lake Idku, the third largest wetland region in Egypt regarding the physicochemical indicators, the spatial distributions of certain trace elements and organochlorine compounds (OCs). Most of the tested water quality indicators were above the permissible limits of River Nile water except nitrate was lower than the permissible limits. The distribution and concentrations of Fe, Cu, Zn, Mn, Pb, and Cd significantly differed (p > 0.05) among the sampling sites, where mean concentrations of these trace elements in all the tested sites ranged from 0.0226–0.0392, 0.010–0.098, 0.3570–1.0160, 0.084–0.942, 0.015–0.024, and 0.011–0.023 mg/L, respectively. The west site of the lake contained the highest contents of the trace elements, followed by the east, north, and then south sites. Water collected from the south site had the highest concentrations of Fe and Cu, while those collected from the west site had the highest concentrations of Zn, Pb, and Cd, and samples from the east site had the highest concentrations of Mn. The concentrations of Cu, Zn, Pb, Cd, and Mn in all samples which exceeded the Egyptian regulations, except those collected from the south site which contained levels of Mn that met the regulations. Regarding the residues of OCs, the ∑OCs can be grouped in descending order as follows: north site > east site > west site > south site, with values of 5.632, 5.230, 4.731, and 4.650 µg/L, respectively. All the detected OCs were above the maximum acceptable levels as compared to WHO standards of 0.1 μg/L, except for p,p'-DDT, p,p'-DDD, and p,p'-DDE which were at lower levels. In conclusion, the water quality of Lake Idku may at risk to biota and humans, monitoring, management, and mitigation strategies are urgently required to prevent further pollution by restricting the discharge of industrial and agricultural wastewater into Lake Idku.
Painful diabetic neuropathy is associated with accelerated epigenetic aging
Authors: Kwiatkowska Katarzyna Malgorzata , Garagnani Paolo , Bonafé Massimiliano , Bacalini Maria Giulia , Calzari Luciano , Gentilini Davide , Ziegler Dan , Gerrits Monique M. , Faber Catharina G. , Malik Rayaz A. , Marchi Margherita , Salvi Erika , Lauria Giuseppe , Pirazzini Chiara 
Published: January 2025

Abstract
About one out of two diabetic patients develop diabetic neuropathy (DN), of these 20% experience neuropathic pain (NP) leading to individual, social, and health-economic burden. Risk factors for NP are largely unknown; however, premature aging was recently associated with several chronic pain disorders. DNA methylation-based biological age (DNAm) is associated with disease risk, morbidity, and mortality in different clinical settings. The purpose of this work was to study, for the first time, whether biological age is involved in pain development in a huge cohort of DN patients with neuropathy assessed by anatomopathological assay (99 painful (PDN), 132 painless (PLDN) patients, 84 controls (CTRL)). Six subsets of DNAm biomarkers were calculated to evaluate NP-associated changes in epigenetic aging, telomere shortening, blood cell count estimates, and plasma protein surrogates. We observed pain-related acceleration of epigenetic age (DNAmAgeHannum, DNAmGrimAgeBasedOnPredictedAge, DNAmAgeSkinBloodClock), pace of aging (DunedinPoAm), and shortening of telomeres between PDN and PLDN patients. PDN showed decreased predicted counts of B lymphocytes, naive and absolute CD8 T cells, and increased granulocyte counts. Several surrogates of plasma proteins were significantly different (GHR, MMP1, THBS2, PAPPA, TGF-α, GDF8, EDA, MPL, CCL21) in PDNs compared to PLDNs. These results provide the first evidence of an acceleration of biological aging in patients with painful compared to painless DN. This achievement has been possible thanks to the state of the art clinical phenotyping of the enrolled patients. Our findings indicate that the aging process may be directly involved in the PDN progression and in general health degeneration in the T2DM patients. Therefore, it is possible to hypothesize that the administration of effective antiaging drugs could slow down or even block the disease advancement.
Saprotrophic fungal community responses to nitrogen additions in a Korean pine plantation: insights from using the mycoindicator
Authors: Wu Ruotong , Zhang Huanhuan , Zhang Mengmeng , Jin Guangze , Song Fuqiang 
Published: January 2025

Abstract
Human activities contribute to elevated nitrogen input in terrestrial ecosystems, influencing the composition of soil nutrients and microbial diversity in forest ecosystems. In this study, we built four addition treatments (0, 20, 40, and 80 kg ha−1 a−1 N for 6 a) at a Korean pine plantation of different soil horizons (organic (O) horizon, ranging from 0 to 10 cm, and organomineral (A) horizon, extending from 10 to 20 cm) to evaluate responses of the structure of saprophytic fungal communities. Here, 80 kg ha−1 a−1 N treatment significantly decreased the community richness in soil A horizon with the Chao1 index decreasing by 12.68%. Nitrogen addition induced changes in the composition of saprophytic fungi community between the different soil horizons. The co-occurrence network and its associated topological structure were utilized to identify mycoindicators for specific fungi to both soil horizons and nitrogen addition levels. In soil O horizon, the mycoindicators included Penicillium, Trichoderma, Aspergillus, and Pseudeurotium across control, low, medium, and high nitrogen treatments. In soil A horizon, Geomyces, Cladophialophora, Penicillium, and Pseudeurotium were identified as mycoindicators. Structural equation modeling determined NH4
+-N as the key factor driving changes in saprotrophic fungal communities. Our study aimed to screen mycoindicators that can respond to the increasing global nitrogen deposition and to assess the roles of these mycoindicators in the saprophytic fungal community structure within Korean pine plantations in northeast China.
Off-pump versus on-pump coronary artery bypass grafting in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
Authors: Cappellaro Anelise Poluboiarinov , de Almeida Luiz F. Costa , Pinto Manoela Lenzi , Martins Marcelo Albuquerque Barbosa , Sousa Augusto Graziani e , Gadelha Júlia Gonçalves , Vieira Ana Carolina Putini , Rocha Luís Fernando Rosati , Thet Myat Soe 
Published: January 2025

Abstract

Introduction
Off-pump coronary artery bypass graft surgery (OPCAB) has been suggested as superior to on-pump coronary artery bypass graft surgery (ONCAB) in certain high-risk subgroups, but its benefit in patients with chronic obstructive pulmonary disease (COPD) remains controversial. This meta-analysis aimed to evaluate OPCAB versus ONCAB outcomes in COPD patients.

Methods
We followed PRISMA guidelines and searched PubMed, Embase, and the Cochrane Library in August 2024 for studies comparing OPCAB and ONCAB in COPD patients. Statistical analysis was conducted using Review Manager 5.4.1 and Rstudio with a fixed or random effects model.

Results
Six studies with a total of 1,687 patients were included, of which 1,062 (62.95%) underwent OPCAB. The mean patient age was 63.6 years. OPCAB did not significantly affect all-cause mortality compared to ONCAB (OR 1.14; 95% CI 0.65–1.99). There were no significant differences in reintubation (OR 0.81; 95% CI 0.53–1.23), prolonged ventilation (OR 0.54; 95% CI 0.24–1.22), post-operative atrial fibrillation (OR 0.90; 95% CI 0.70–1.15), or ARDS (OR 0.43; 95% CI 0.14–1.33). However, ventilation time was significantly shorter in the OPCAB group (MD – 5.30 h; 95% CI – 7.22 to – 3.38).

Conclusion
OPCAB is associated with reduced ventilation time in COPD patients though it shows no significant difference in all-cause mortality or other post-operative complications compared to ONCAB.
Effects of data-driven respiratory gating on visualization and quantification of breast and upper abdominal cancers in FDG PET/CT examinations
Authors: Tatsumi Mitsuaki , Morita Naomi , Kida Akira , Momoi Risa , Isohashi Kayako , Okada Atsuya , Tomiyama Noriyuki 
Published: January 2025

Abstract

Objective
Data-driven respiratory gating (DDG) has recently been introduced to improve image quality in the PET portion of PET/CT examinations. The latest DDG system does not require any external equipment or extended examination time. In this study, we investigated the effects of the new DDG system on the visualization and quantification of breast and upper abdominal cancers, comparing the results with those obtained using the standard free-breathing (STD) PET protocol.

Methods
A total of 223 cancer lesions (138 breast and 85 upper abdominal) evaluated with FDG PET/CT were included in this study. PET images were reconstructed using the STD and DDG algorithms. Lesion blurring and conspicuity were each visually graded on a three-point scale. The longest diameter (LD), SUVmax, and metabolic tumor volume (MTV) of the lesions were used for quantitative analysis. % change in SUVmax or MTV was calculated from the metrics in STD and DDG images. Fifty-six texture features (TFs) were also evaluated. Visual scores and quantitative metrics were compared between STD and DDG images. % change in SUVmax or MTV was compared in the lesion location groups or in the high and low groups based on LD, SUVmax, or MTV in STD images.

Results
Visual scores for lesion blurring and conspicuity were both significantly higher in DDG than in STD PET images. SUVmax and MTV were significantly higher and lower, respectively, in DDG than in STD images. An increase in SUVmax and a decrease in MTV were observed in 96% and 86% of all lesions, respectively. Group analysis revealed that % change in SUVmax was greater in the upper abdominal than the breast lesions and % change in MTV was greater in the high LD and high MTV groups than in the low LD and low MTV groups, respectively. Quantitative changes in TFs were observed between STD and DDG images for most of the features.

Conclusion
This study demonstrated that DDG improved visualization and quantification of breast and upper abdominal cancers in FDG PET/CT examinations. DDG PET images exhibited an increase in SUVmax, a decrease in MTV, and changes in TFs.
Early intervention in eating disorders: introducing the chronopathogram
Authors: Preti Antonio , Bevione Francesco , Lacidogna Maria Carla , Raballo Andrea , Poletti Michele , Abbate-Daga Giovanni 
Published: January 2025

Abstract
Eating disorders (EDs) pose significant challenges to mental and physical health, particularly among adolescents and young adults, with the COVID-19 pandemic exacerbating risk factors. Despite advancements in psychosocial and pharmacological treatments, improvements remain limited. Early intervention in EDs, inspired by the model developed for psychosis, emphasizes the importance of timely identification and treatment initiation to improve prognosis. Challenges in identifying prodromal phases and measuring the duration of untreated illness highlight the complexity of early intervention efforts in EDs. Current research focuses on reducing the duration of untreated eating disorder (DUED) and understanding the cognitive and behavioral symptoms preceding ED onset. However, current early intervention programs for EDs showed mixed results, necessitating further investigation. We introduce here the chronopathogram, a tool that may aid in precisely investigating the role of development in EDs. A chronopathogram is a graphical representation of pathological events as they unfold over time. Understanding the neurodevelopmental aspects of EDs and utilizing tools like the chronopathogram can aid in tracking the unfolding of symptoms over time, facilitating early detection and intervention efforts. Overall, addressing the key factors influencing the onset and course of EDs is essential for effective early intervention in these conditions.

Level of evidence: Level V narrative review.
Treatment and Monitoring of Eosinophilic Fasciitis
Authors: Selva-O’Callaghan Albert , Trallero-Araguás Ernesto , Gil-Vila Albert , Guillen-Del Castillo Alfredo , Matas-García Ana , Milisenda Jose Cesar , Simeon-Aznar Carmen Pilar , Pinal-Fernandez Iago 
Published: January 2025

Abstract

Purpose of Review
Eosinophilic fasciitis (EF) is a rare inflammatory disease characterized by skin induration. Although some guidelines from scientific societies exist, standard recommendations on monitoring and therapy are lacking.

Recent Findings
Current therapy for patients diagnosed with EF includes glucocorticoids plus at least one immunosuppressive drug in cases of relapse or refractory disease. Methotrexate and mycophenolate mofetil are the most recommended, although recently a myriad of case reports or small series reporting the effectivity of biological agents or JAK inhibitors for treating relapses or refractory disease have been published. Anti-IL5 may have a role in those rare refractory cases with persistent eosinophilia. Intravenous immunoglobulins and photopheresis (in those centers with experience) may act as adjuvant therapies. Monitoring the disease activity is a cornerstone to ascertain if the treatment is useful or not. MRI, PET/TC, and more specifically POCUS have recently demonstrated their value for assessing therapy response.

Summary
High-quality data focused on therapy and monitoring is lacking in EF. Strategies for improving scientific quality of observational studies and consensus about “activity”, “sequela”, “relapse” or “refractoriness” terms in EF patients are necessary to implement prospective clinical trials and generate evidence-based medicine. Meanwhile we have to deal with the available information.
Righting Relationships: Reclaiming Places, Spaces, and Lifeways
Authors: Machado-Escudero Yolanda , Gilliam Christa C. , Prussia Leah 
Published: January 2025

Abstract
The intersections of climate change, environmental justice, government policy, and impacts on rights of nature and humans are examined by exploring urban and rural community narratives on displacement and gentrification. The narratives provide an overview of how past/present policies and environmental justice issues negatively affect marginalized communities and ecosystems. The narratives also attend to the resilience and resistance of tribal communities and communities of color in navigating the return of land to its original inhabitants. Strategies for righting, reclaiming, and protecting places, spaces, and lifeways are highlighted by sharing ancestral and emerging collective actions from tribal, urban, and island localities in hopes to inform the social work profession’s future allyship, advocacy, and action.
Length-Minimizing LED Trees
Authors: Sarkociová Remešíková Mariana , Sarkoci Peter , Trnovská Mária 
Published: January 2025

Abstract
In this paper, we introduce a previously not studied type of Euclidean tree called LED (Leaves of Equal Depth) tree. LED trees can be used, for example, in computational phylogeny, since they are a natural representative of the time evolution of a set of species in a feature space. This work is focused on LED trees that are length minimizers for a given set of leaves and a given isomorphism type. The underlying minimization problem can be seen as a variant of the classical Euclidean Steiner tree problem. Even though it has a convex objective function, it is rather non-trivial, since it has a non-convex feasible set. The main contribution of this paper is that we prove the uniqueness of a stationary point of the length function on the feasible set. Moreover, we prove several geometrical characteristics of the length minimizers that are analogous to the properties of Steiner minimal trees. We also explore some geometrical and topological properties of the feasible set. At the end, to demonstrate the applicability of our theoretical results, we show an example of an application in historical linguistics.