bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory of Healthcare Contact Days for Veterans With Advanced Gastrointestinal Malignancy
Authors: Johnson Whitney V , Phung Quan H , Patel Vishal R , Tsai Alexander K , Arora Nivedita , Klein Mark A , Westanmo Anders D , Blaes Anne H , Gupta Arjun 
Published: November 2023

Abstract
How and where patients with advanced cancer facing limited survival spend their time is critical. Healthcare contact days (days with healthcare contact outside the home) offer a patient-centered and practical measure of how much of a person’s life is consumed by healthcare. We retrospectively analyzed contact days among decedent veterans with stage IV gastrointestinal cancer at the Minneapolis Veterans Affairs Healthcare System from 2010 to 2021. Among 468 decedents, the median overall survival was 4 months. Patients spent 1 in 3 days with healthcare contact. Over the course of illness, the percentage of contact days followed a “U-shaped” pattern, with an initial post-diagnosis peak, a lower middle trough, and an eventual rise as patients neared the end-of-life. Contact days varied by clinical factors and by sociodemographics. These data have important implications for improving care delivery, such as through care coordination and communicating expected burdens to and supporting patients and care partners.
Carboxyl nanodiamonds inhibit melanoma tumor metastases by blocking cellular motility and invasiveness
Authors: Behera Sushreesangita P , Tyagi Witty , Saxena Rajiv K 
Published: November 2023

Abstract
Carboxyl nanodiamond (cND) nanoparticles are actively internalized by B16F10 melanoma cells in culture. Treatment of B16F10 tumor cells with cNDs in vitro inhibited their ability to (i) migrate and invade through porous membranes in a transwell culture system, (ii) secrete matrix metalloproteinases (MMPs) MMP-2 and MMP-9, and (iii) express selected epithelial–mesenchymal transition markers critical for cell migration and invasion. Administration of luciferase-transfected B16F10-Luc2 melanoma cells resulted in a rapid growth of the tumor and its metastasis to different organs that could be monitored by in vivo bioluminescence imaging as well as by ex vivo BLI of the mouse organs. After tumor cells were administered intravenously in C57Bl/6 mice, administration of cNDs (50 μg i.v. every alternate day) resulted in marked suppression of the tumor growth and metastasis in different organs of mice. Subcutaneous administration of B16F10 cells resulted in robust growth of the primary tumor subcutaneously as well as its metastasis to the lungs, liver, spleen, and kidneys. Intravenous treatment with cNDs did not affect the growth of the primary tumor mass but essentially blocked the metastasis of the tumor to different organs. Histological examination of mouse organs indicated that the administration of cNDs by itself was safe and did not cause toxic changes in mouse organs. These results indicate that the cND treatment may have an antimetastatic effect on the spread of B16F10 melanoma tumor cells in mice. Further exploration of cNDs as a possible antimetastatic therapeutic agent is suggested.
Outsourcing authority in global policy: legitimating the anti-money laundering regime through professionalization
Authors: Tsingou Eleni 
Published: November 2023

Abstract
How is authority legitimated when global policy leads to the delegation of implementation and monitoring tasks to private actors? This paper shows that putting private actors at the forefront of compliance gives them significant interpretation autonomy, with knock-on effects for how rule-making authority is legitimated. I show that actors can mobilize to claim expertise based on their practice in, and input to, transnational administration and that professional associations are important arenas for establishing and legitimating these claims. The paper explores these dynamics through an empirical focus on the global anti-money laundering regime. Revolving around the Financial Action Task Force, the regime to tackle illicit finance has been a highly political process with a global reach. Yet it relies heavily on financial institutions to put systems in place that control the flow of money. This puts private compliance officers at the forefront of transnational administration. The paper shows that compliance officers have responded to the demands of this role by professionally organizing. Focusing on the largest professional association, the Association of Certified Anti-Money Laundering Specialists or ACAMS, a US-based association with a global program and membership, the paper explains that professionalization mechanisms have helped demarcate practice boundaries and support the expertise claims of private sector employees. By becoming the experts, these officers can claim pragmatic authority over what global policy rules and standards mean and how they can be implemented.
abYpap: improvements to the prediction of antibody VH/VL packing using gradient boosted regression
Authors: Boron Veronica A , Martin Andrew C R 
Published: November 2023

Abstract
The Fv region of the antibody (comprising VH and VL domains) is the area responsible for target binding and thus the antibody’s specificity. The orientation, or packing, of these two domains relative to each other influences the topography of the Fv region, and therefore can influence the antibody’s binding affinity. We present abYpap, an improved method for predicting the packing angle between the VH and VL domains. With the large data set now available, we were able to expand greatly the number of features that could be used compared with our previous work. The machine-learning model was tuned for improved performance using 37 selected residues (previously 13) and also by including the lengths of the most variable ‘complementarity determining regions’ (CDR-L1, CDR-L2 and CDR-H3). Our method shows large improvements from the previous version, and also against other modeling approaches, when predicting the packing angle.
Missions and Cohesion Policy: is there a match?
Authors: Cappellano Francesco , Molica Francesco , Makkonen Teemu 
Published: November 2023

Abstract
This paper explores possibilities for cross-fertilization between the mission-oriented approach (MOA), informing the European Union (EU) Missions, and Cohesion Policy (CP). It argues for mutual policy learning between CP and MOA to address their shortcomings: CP faces a gradual erosion of its identity, while MOA lacks a territorial perspective. MOA can offer a theoretical ‘blueprint’ for reorganizing and clarifying CP’s ever-expanding and blurred thematic scope, providing direction to strengthen CP’s result orientation, and encouraging the adoption of ‘whole-of-government’ approaches to streamline CP’s complex governance relationships. MOA can benefit from adopting the CP architecture, which allows for common broad priorities to be adapted to territorial contexts and to regional strategies. MOA could also learn from CP’s goal of maximizing equity and efficiency, its focus on empowering regions, and its redistributive approach for fostering the full potential of all regions to address societal challenges to support the objectives of the EU Missions.
Genetic Racialization: Ancestry Tests and the Reification of Race
Authors: Zarrugh Amina , Romero Luis 
Published: November 2023

Abstract
While there has been a significant increase in the availability of DNA testing to identify one’s ancestry, we know little about the implications of these services for everyday social meanings of race and ethnicity. Scholarship about ancestry testing generally focuses on the significance of DNA testing for individual consumers who lack access to genealogical history, often due to systemic racism and inequality. Drawing on an analysis of over 400 videos uploaded by people who have utilized DNA testing kits to uncover their ancestry, this article focuses on how ancestry testing is mediated in the public sphere and its implications for social understandings of race and ethnicity. We find that consumers of DNA-based ancestry testing engage in what we term “genetic racialization,” in which they emphasize the primacy of science to uncover their ancestral connections, and, by extension, biologize notions of race and ethnicity and omit histories of colonialism and conquest in the social construction of race. The vocabulary of “blood” provides a key framework from which individuals interpret their ancestry results and implicitly draw on colonial frameworks of blood quantum and purity to define what it means to belong to particular racial and ethnic groups.
Neurodevelopmental Outcomes After Prenatal Exposure to Anesthesia for Maternal Surgery: A Propensity-score Weighted Bidirectional Cohort Study
Authors: Bleeser T. , Devroe S. , Lucas N. , Debels T. , Van de Velde M. , Lemiere J. , Deprest J. , Rex S. 
Published: November 2023

(Anaesthesia. 2023;78:159–169)
One percent or less of women undergo nonobstetric surgery during pregnancy and require anesthesia. While a recent animal study showed general anesthesia (GA) during pregnancy can increase the risk of fetal neuronal injury, it is uncertain whether the same outcomes are seen in the clinical setting. This study investigated whether exposure to GA in-utero increases the risk of neurodevelopmental impairment outcomes in children, comparing exposed and unexposed children.
Association Between Marked Fetal Heart Rate Variability and Neonatal Acidosis: A Prospective Cohort Study
Authors: Loussert L. , Berveiller P. , Magadoux A. , Allouche M. , Vayssiere C. , Garabedian C. , Guerby P. 
Published: November 2023

(BJOG. 2023;130:407–414)
Although it has been considered the standard of care to evaluate the fetus during labor, intrapartum electronic fetal monitoring (EFM) is controversial in its effectiveness for reducing cerebral palsy and perinatal mortality. Research on fetal heart rate (FHR) analysis has demonstrated high interobserver variability and with low specificity. Further, the pathophysiology of FHR marked variability is not well understood and research is limited.
The Impact of Preoperative Ultrasound and Intraoperative Findings on Surgical Outcomes in Patients at High Risk of Placenta Accreta Spectrum
Authors: Hussein A.M. , Fox K. , Bhide A. , Elbarmelgy R.A. , Elbarmelgy R.M. , Thabet M.M. , Jauniaux E. 
Published: November 2023

(BJOG. 2023;130:42–50)
When placental villous tissue abnormally attaches to the uterine wall it is known as placenta accreta spectrum (PAS). A large number of PAS cases are seen in the setting of placenta previa and previous cesarean delivery (CD). Removing placental villous tissue at delivery typically results in hemorrhaging. This hemorrhaging has been proven to be reduced when PAS is caught before delivery. Studies show that PAS is missed before delivery in over 50% of cases. This study aimed to determine how preoperative ultrasound can help to detect PAS in patients prior to delivery.
Hush Little Baby: Promise of the Eat, Sleep, Console Approach
Authors: Barfield W.D. 
Published: November 2023

(N Engl J Med. 2023;388:2391–2392)
In this editorial written on the recent article by Young et al, entitled “Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal,” Barfield reviews the findings while also discussing the study limitations and need for further investigations. The original study explored using a nonpharmacologic interventions called Eat, Sleep, Console for the treatment of neonatal opioid withdrawal syndrome. The Eat, Sleep, Console tool involves a greater emphasis on meeting the needs of the infant holistically. This approach is appealing due to rising rates of infants diagnosed with neonatal opioid withdrawal syndrome, which puts a greater stress on hospital staff due to the need of longer hospital stays to treat the neonates. Overall, the study found that the use of the Eat, Sleep, Console intervention reduced hospital stay lengths and reduced use of pharmacologic therapy, without significant differences in safety measures assessed at 3 months of age.
Aspirin Discontinuation at 24 to 28 Weeks’ Gestation in Pregnancies at High Risk of Preterm Preeclampsia: A Randomized Clinical Trial
Authors: Mendoza M. , Bonacina E. , Garcia-Manau P. , López M. , Caamiña S. , Vives À. , Lopez-Quesada E. , Ricart M. , Maroto A. , de Mingo L. , Pintado E. , Ferrer-Costa R. , Martin L. , Rodríguez-Zurita A. , Garcia E. , Pallarols M. , Vidal-Sagnier L. , Teixidor M. , Orizales-Lago C. , Pérez-Gomez A. , Ocaña V. , Puerto L. , Millán P. , Alsius M. , Diaz S. , Maiz N. , Carreras E. , Suy A. 
Published: November 2023

(JAMA. 2023;329:542–550)
Globally, 70,000 maternal deaths and 500,000 fetal deaths each year can be attributed to preeclampsia, which affects roughly 2-4% of pregnancies. Diagnosis of preeclampsia falls into several categories depending on gestational age at diagnosis, with early-onset preeclampsia (delivery <34 wk), preterm preeclampsia (delivery <37 wk), and term preeclampsia (delivery at or past 37 wk). Many serious complications can be associated with a diagnosis of preeclampsia, including preterm birth, fetal growth restriction, placental abruption, seizures, and others, with earlier onset correlating with more severe complications. Previous research has identified aspirin as an effective way to reduce the incidence of preeclampsia in high-risk individuals, especially when treatment is initiated in the late first trimester or early second trimester.
Umbilical Cord Milking in Nonvigorous Infants: A Cluster-Randomized Crossover Trial
Authors: Katheria A.C. , Clark E. , Yoder B. , Schmölzer G.M. , Yan Law B.H. , El-Naggar W. , Rittenberg D. , Sheth S. , Mohamed M.A. , Martin C. , Vora F. , Lakshminrusimha S. , Underwood M. , Mazela J. , Kaempf J. , Tomlinson M. , Gollin Y. , Fulford K. , Goff Y. , Wozniak P. , Baker K. , Rich W. , Morales A. , Varner M. , Poeltler D. , Vaucher Y. , Mercer J. , Finer N. , El Ghormli L. , Rice M.M. ,   of the Milking In Nonvigorous Infants group
Published: November 2023

(Am J Obstet Gynecol. 2023;228:217.e1–217.e14)
Mortality rates among infants that need resuscitation after birth is high despite recent advancements in resuscitation technology. The potential consequences of the need for resuscitation include a host of neurological disorders and problems, which underscores the need for maximizing effectiveness of treatment to stabilize these infants. One method that has been shown to benefit newborns in the first few minutes after birth is delayed cord clamping; for infants who require resuscitation; however, this is typically foregone in favor of immediate efforts to help them breathe.
Presence of the Partner in the Operating Room During Emergency Cesarean Section: A Scoping Review
Authors: Nedergaard H.K. , Balaganeshan T. , Weitling E.E. , Petersen H.S. , Brøchner A.C. 
Published: November 2023

(Eur J Anaesthesiol. 2022;39:939–952)
Having a partner as a support person during vaginal delivery and elective cesarean delivery (CD) is common in many countries worldwide and has well-documented benefits. In emergent CD the decision of having a partner in the operating room (OR) is not as clear given the complex, fast-paced, and high-risk nature of the situation. The aim of this review is to describe available published opinions and evidence regarding the partner’s presence in the OR during emergency CD.
Long-Term Impairment of the Blood-Spinal Cord Barrier in Patients With Post-Traumatic Syringomyelia and its Effect on Prognosis
Authors: Yuan Chenghua , Xia Pingchuan , Duan Wanru , Wang Jiachen , Guan Jian , Du Yueqi , Zhang Can , Liu Zhenlei , Wang Kai , Wang Zuowei , Wang Xingwen , Wu Hao , Chen Zan , Jian Fengzeng 
Published: November 2023

Study Design.
Cohort study.

Objective.
The aim of this study was to explore the association between blood-spinal cord barrier (BSCB) markers and other factors associated with an unfavorable outcome among patients with post-traumatic syringomyelia (PTS) who achieved successful intradural adhesion lysis (IAL).

Summary of Background Data.
Only approximately half of PTS patients receiving IAL have a favorable outcome.

Patients and Methods.
Forty-six consecutive patients with PTS and 19 controls (CTRL) were enrolled. All PTS patients underwent physical and neurological examinations and spinal magnetic resonance imaging before and 3 to 12 months after IAL. All patients underwent myelography before surgery. BSCB disruption was detected by increased intrathecal and serum concentrations of albumin, immunoglobulin (Ig)G, IgA, and IgM. A multivariable analysis was performed with a logistic regression model to identify factors associated with unfavorable outcomes. Receiver operating characteristic curves were calculated to investigate the diagnostic value of biomarkers.

Results.
The ages and general health of the PTS and CTRL groups did not differ significantly. QAlb, IGAQ, IGGQ, and IGMQ was significantly higher in PTS patients than in controls (P=<0.001). The degree of intradural adhesion was significantly higher in the unfavorable outcome group than in the favorable outcome group (P<0.0001). QAlb, immunoglobulin (Ig)AQ, IGGQ, and IGMQ was significantly correlated with clinical status (R=−0.38, P<0.01; R=−0.47, P=0.03; R=−0.56, P=0.01; R=−0.43, P=0.05, respectively). Higher QAlb before surgery (odds ratio=2.66; 95% CI: 1.134–6.248) was significantly associated with an unfavorable outcome. The receiver operating characteristic curve analysis demonstrated a cutoff for QAlb higher than 10.62 with a specificity of 100% and sensitivity of 96.3%.

Conclusion.
This study is the first to detect increased permeability and BSCB disruption in PTS patients. QAlb>10.62 was significantly associated with unfavorable clinical outcomes following intradural decompression.

Level of Evidence.
Level III—prognostic.
Physician–hospital alignment
Authors: Brinsfield Chad T. , Priore Richard J. , Wehbi Nizar K. 
Published: November 2023

The alignment of physicians’ interests with those of their hospital has garnered considerable interest in recent years, in part because of their central role in health care expenditure and patient outcomes. However, the systematic study of physician–hospital alignment is currently impeded by a lack of construct clarity. This is evidenced by research that conflates the actions intended to create alignment with alignment itself. It is also evidenced by a variety of different definitions, conceptualizations, and measures in the literature, most of which are confounded with constructs that are something other than alignment (e.g., commitment, trust).

Critical Theoretical Analysis
We draw on agency theory and person–organization fit to define physician–hospital alignment as a physician’s perception that their financial incentives, goals, and values and those of their hospital are mutually supporting and reinforcing rather than in conflict with one another.

Advance
To better understand the nature of the construct and to help guide future research, we present an integrative framework grounded in physicians’ perceptions.

Practice Implication
Our definition and framework set the stage for improved construct validation and more systematic study and management of physician–hospital alignment.
System justification theory as a foundation for understanding relations among toxic health care workplaces, bullying, and psychological safety
Authors: Porter Tracy H. , Rathert Cheryl , Ishqaidef Ghadir , Simmons Derick R. 
Published: November 2023

Background
Toxic work environments and bullying are rampant in health care organizations. The Joint Commission asserted that bullying is a threat to patient safety, and furthermore, it implied that bullying affects clinician psychological safety. However, after decades of trying to reduce bullying, it persists.

Purpose
The purpose of this study was to determine if system justification (SJ) theory can help explain the persistence of bullying in health care organizations. SJ theory posits that people are motivated to justify the systems with which they are embedded, even if those systems are dysfunctional or unfair.

Method
A cross-sectional survey of health care workers (n = 302) was used to test a moderated mediation model to examine relations between instrumental work climate perceptions and psychological safety, as mediated by SJ and moderated by experiences of workplace bullying.

Results
Analysis revealed that SJ fully mediated negative relations between instrumental climate and psychological safety; because of SJ the instrumental climate no longer had a direct negative association with psychological safety. Furthermore, bullying was found to play a moderating role in the instrumental climate–SJ relationship.

Conclusion
This study found some support for the role of SJ in perpetuating instrumental workplaces and workplace bullying in health care.

Practice Implications
Some scholars have proposed that a focus on disrupting workplace contexts that trigger SJ in workers could help break patterns of behavior that enable toxic work environments and bullying to persist.
Pay practices and safety organizing
Authors: Conroy Samantha A. , Vogus Timothy J. 
Published: November 2023

Background
Our understanding of how highly reliable care delivery is brought about remains elusive, in part, because there is limited evidence regarding the organizational practices that enable safety organizing—the behaviors and processes underlying high reliability.

Purpose
Because safety organizing relies on discretionary effort and lowering barriers to sharing expertise and discussing threats to safety and errors, we investigate three pay practices and their effects on information sharing and, in turn, safety organizing. Specifically, we examine average pay level, minimum pay rates, and pay dispersion on nursing units and their relationship with information sharing and safety organizing.

Method
Cross-sectional analyses of survey data from 1,461 registered nurses in 45 nursing units in three Midwestern hospitals on safety organizing linked to administrative data on pay practices from the organization’s human resource systems. Pay data and survey responses were aggregated to the nursing unit level. PROCESS and structural equation modeling were used to simultaneously test for direct and indirect effects of pay variables on information sharing and safety organizing.

Results
PROCESS and Mplus path analysis indicated that paying a higher minimum rate in the unit and having lower pay dispersion have indirect, desirable associations with safety organizing through information sharing.

Conclusion
Pay practices can help organizations enhance safety organizing. In particular, higher pay rates for the lowest level nurses and lower pay dispersion among nurses are associated with unit-level information sharing and safety organizing.

Practice Implications
Having pay practices associated with lower within-unit variation and higher pay for the lowest paid members of a unit may be viable strategies for greater information sharing and safety organizing.