bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics, Treatment Patterns and Outcomes of Hospitalized Patients with Acute Heart Failure at Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia: A Cross-Sectional Study
Authors: Solela Gashaw , Seid Yimer 
Published: December 2023

Abstract
Background: Acute heart failure (HF) is a rapid onset of new or worsening of symptoms and signs of heart failure (HF). Despite the increasing burden of HF in developing countries like Ethiopia, there is a paucity of comprehensive data with respect to clinical characteristics, treatment patterns and outcomes of acute HF.
Objectives: The objective of this study is to assess the clinical characteristics, treatment patterns and outcomes of hospitalized patients with acute heart failure at Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia, in a year period between July 1, 2022 and July 1, 2023.
Methods: This is a cross-sectional study of 303 acute HF patients who were admitted to the medical wards and intensive care unit of Yekatit 12 Hospital Medical College from July 1, 2022 to July 1, 2023. Pretested data abstraction format was used for data collection and SPSS version 26 was used for data analysis. Descriptive analysis was used to summarize sociodemographic data, clinical characteristics, treatment patterns and in-hospital outcomes of acute HF. Binary logistic regression analysis was used to determine the associated factors of in-hospital mortality. Odds ratio (OR) with the corresponding 95% confidence interval (CI) was calculated to show the strength of association.
Results: Of 303 patients, 51.5% were females and the median age was 56.7 years. The most frequent symptom and sign were dyspnea (98.7%) and peripheral edema (79%), respectively. The commonest underlying cause and precipitating factor of acute HF were cor pulmonale (22.8%) and pneumonia (35.3%), respectively. The commonest anti-remodeling medications prescribed at the time of discharge were beta blockers (47.7%) followed by MRAs (42.8%) and ACE inhibitors/ARBs (38.6%) and the least prescribed were SGLT2 inhibitors (8.3%). The in-hospital mortality rate was 8.6% and the median length of hospital stay was 9 days. Based on the multivariate logistic regression analysis, the most important predictors of in-hospital mortality were systolic blood pressure (SBP) <120mmHg [(AOR) = 6.88; 95% CI: 1.84, 25.82; P value = 0.004], chloride level <96mg/dL [adjusted odds ratio (AOR) =5.23; 95% CI: 1.37, 20.07; P value = 0.016], blood urea nitrogen (BUN) >20mg/dl [AOR =5.28; 95% CI 1.36, 20.53; P value = 0.017] and presence of dyslipidemia [AOR = 4.28, 95% CI: 1.25, 14.64, P value = 0.020].
Conclusions: This study has shown that systolic blood pressure (SBP) <120mmHg, blood urea nitrogen (BUN) >20mg/dL, chloride (Cl–) level <96mg/dL and presence of dyslipidemia were the most important predictor variables of in-hospital mortality for patients with acute HF. Hence, health care providers need to stratify patients with acute HF at admission based on their risk of in-hospital mortality and deal with those potential bad prognostic indicators.
Integrated multi-omics analysis and machine learning based on O_linked_glycosylation genes refine molecular subtypes and prognosis for hepatocellular carcinoma
Authors: Li Hongxu , Gao Jie , Li Minghao , Hu Bowen , Wang Zhihui , Guo Wenzhi , Zhang Yi , Zhang ShuiJun 
Published: December 2023

Abstract
O-glycosylation exerts significant influence on cellular physiological processes and disease regulation by modulating the structure, function, and stability of proteins. However, there is still a lack of research focusing on O-glycosylation in relation to the prognosis of HCC patients. Here we explored expression and function of O-glycosylation gene in HCC from both bulk and single-cell perspectives. The multi-omics data associated with O-glycosylation, identified through the Weighted Gene Co-expression Network Analysis (WGCNA), combined with ten distinct clustering algorithms to define the molecular subgroups of HCC. CS1 was characterized by significant genomic variation, moderate immune cell infiltration and immune function enrichment. CS2 performed a better prognosis, and was featured by stable genomic structure, an immune-hot phenotype with rich immune cell infiltration and sensitive to immunotherapy. CS3 was characterized by a poor prognosis, outstanding genomic instability, an immune-cold phenotype, but can benefit more from treatment with drugs such as sorafenib, cisplatin, paclitaxel, and gemcitabine. Ultimately, we re-emphasized O-glycosylation genes in individual HCC patients, deploying 59 types of machine learning to construct and evaluate the prognostic signature. The microarray results indicated a pronounced upregulation of Oglycosylation hub genes involved in HCC stratification and modeling within HCC tumorous tissues. In conclusion, we have highlighted the significant impacts of O-glycosylation on HCC by redefining the subtypes of HCC as well as constructing the CMLS. This research has established an optimized decision-making platform that enables precise stratification of HCC patients, refines tumor treatment plans, and predicts patient survivability holding broad clinical implications.
Single Nucleotide Polymorphisms of NLRP12 Gene and Association with Psoriasis
Authors: Li Jiawei , Hui Yun , Gao Yingjun , Kong Qingtao , Liu Haibo , Sang Hong , Liu Fang 
Published: December 2023

Abstract
Background
NLRP12 has been authenticated as an important negative regulator in multiple metabolic and inflammatory diseases. Psoriasis is an important inflammatory disease and often suffer from comorbidities such as inflammatory bowel disease, obese, etc. However, the role of NLRP12 in psoriasis remains unexplored.
Methods
SNP mutation sites of NLRP12 gene were screened in psoriasis and control groups, followed by genotyping and correlation analysis. The expression of NLRP12 gene and protein in blood and tissue samples of psoriasis patients were determined by Quantitative Real-time polymerase chain reaction (qPCR), immunohistochemistry and Western Blot.
Results
We found a significant increase in the mutation frequency of NLRP12 rs12460528 co-dominant model, particularly in the dominant model. The dominant model GG + GA of NLRP12 rs12460528 exhibited an OR value of 4.167 (1.847–9.402). Furthermore, the qPCR results a significant upregulation of NLRP12 mRNA expression in psoriatic lesions and peripheral blood. The expression of NLRP12 protein was observed to be significantly elevated in psoriatic tissue by immunohistochemistry and Western Blot.
Conclusions
The results indicated SNP rs12460528 is a potential locus related to NLRP12 in psoriasis. And allele G had a protective effect on psoriasis. NLRP12 was significantly associated with psoriasis and may play a positively regulating role in psoriasis.
Nail-patella syndrome with nephropathy in a de novo LMX1B mutation: Triangular lunula of the thumb and lack of finger creases as clues
Authors: Banno Yoshinori , Ikemiyagi Masako , Hamada Riku , Nozu Kandai , Matsuoka Kentaro , Kamimaki Isamu 
Published: December 2023

Abstract
Nail-patella syndrome (NPS) is an autosomal dominant disease caused mostly by mutations in the LMX1B gene and is characterized by hypoplastic nails, hypoplastic patella, elbow deformities, glaucoma, and nephropathy, sometimes leading to kidney failure. The combination and the severity of symptoms vary greatly from patient to patient. Because a kidney biopsy may show nonspecific findings, patients with nephropathy alone may not be diagnosed without undergoing genetic testing. We examined the case of a 6-year-old girl with persistent high proteinuria who was not diagnosed by kidney biopsy but had a diagnosis of a de novo mutation in the LMX1B gene following genetic testing. Retrospectively, only the thumbs showed triangular lunulae, while the third and fourth fingers lacked skin creases over the distal interphalangeal joints, which is subtle but characteristic of NPS. Notifying pediatric nephrologists of these findings can help avoid unnecessary kidney biopsies and lead to early detection of the disease.
The Effects of Short-Chain Fatty Acid-Butyrate Supplementation on the Expression of Circadian-Clock Genes and Sleep Quality in Patients with Active Ulcerative Colitis: A Double-Blind Randomized Controlled Trial
Authors: Firoozi Donya , Masoumi Seyed Jalil , Asl Seyed Mohammad Kazem Hosseini , Labbe Aurélie , Lankarani Kamran Bagheri , Razeghian-Jahromi Iman , Dara Mahintaj , Fararouei Mohammad 
Published: December 2023

Abstract
Background: Emerging evidence suggests that administering short-chain fatty acids-butyrate could be effective in managing inflammatory bowel disease (IBD), particularly in the regulation of circadian-clock genes, an area of focus in the etiology of IBD. This study was conducted to investigate the effects of sodium butyrate supplementation on the expression of circadian-clock genes, inflammation, sleep and life quality in active ulcerative colitis (UC) patients.
Methods: In the current randomized controlled trial, 36 active UC patients were randomly divided to receive sodium butyrate (600 mg/kg) or placebo for 12-weeks. Before enrolling the first participant, the study received ethical approval from the Research Ethics Committee of Shiraz University of Medical Sciences (reference number: IR.SUMS.SCHEANUT.REC.1400.037) in October 2021, it was registered on IRCT.ir with the registration number IRCT20211214053401N1 on January 1st, 2022. We assessed the expression of circadian clock genes (CRY1, CRY2, PER1, PER2, BMAl1 and CLOCK) by real time polymerase chain reaction (qPCR) in blood as well as faecal calprotectin and serum level of high-sensitivity C-reactive protein (hs-CRP) by enzyme-linked immunosorbent assay method (ELIZA). Moreover, the sleep quality and IBD quality of life (QoL) were assessed by Pittsburgh sleep quality index (PSQI) and inflammatory bowel disease questionnaire-9 (IBDQ-9) respectively before and after the intervention.
Results: The results showed that butyrate supplementation in comparison with placebo significantly upregulated the fold change expression of CRY1 (2.22 (1.59) vs. 0.63 (0.49), p-value < 0.001), CRY2 (2.15 (1.26) vs. 0.93 (0.80), p-value= 0.001), PER1 (1.86 (1.77) vs. 0.65 (0.48), p-value= 0.005), BMAL1 (1.85 (0.97) vs. 0.86 (0.63), p-value= 0.003) and decreased the level of calprotectin (-133.82 (155.62) vs. 51.58 (95.57), p-value <0.001) and hs-CRP (-0.36 (-1.57, -0.05) vs. 0.48 (-0.09-4.77), p-value <0.001). Also, butyrate caused an improvement in the sleep quality (PSQI score: -2.94 (3.50) vs. 1.16 (3.61), p-value <0.001) and QoL (IBDQ-9: 17.00 (11.36) vs. -3.50 (6.87), p-value <0.001).
Conclusion: Butyrate may be an effective adjunct treatment for active UC patients.
A cannabidiol (CBD) oral lipid-based nanoemulsion induces anxiolytic- and panicolytic-like effects and increases delta-FosB immunoreactivity in serotonergic cells of the dorsal raphe lateral wings
Authors: Rosário Bárbara A. , de Lima Maria P. , Vieira Márcio G. , Aquino Pedro E. A. de , Viana Glauce S.B. , Silveira Edilberto R. , de Brito Débora H. A. , Zampieri Dávila , Lemes Jéssica A. , Nazaré Maria F.S. , Ribeiro Daniel A. , Viana Milena de Barros 
Published: December 2023

Abstract

Background: Cannabidiol (CBD) is a phytocannabinoid of Cannabis sativa which seems to hold benefit for anxiety-related disorders. The present study aimed to evaluate the possible anxiolytic- and panicolytic-like effects of an oral lipid-based CBD nanoemulsion in animal models.
Methods: Male Wistar rats were orally treated for 21 consecutive days with CBD (2.5 and 5 mg/kg, 1 mL/kg PO) or vehicle (1 mL/kg) and on the 21st day tested in the avoidance and escape tasks of the elevated T-maze (ETM) for measurements of an anxiety and a panic-related response, respectively. After ETM measurements, animals were also evaluated for anxiety-related behavior in the light/dark transition model and had their motor activity assessed in an open field. Additionally, we evaluated delta-FosB immunoreactivity (Fos-ir) in serotonergic cells of the dorsal raphe (DR).
Results:CBD showed an anxiolytic (decreased ETM avoidance latencies) and a panicolytic-like effect (increased ETM escape latencies) at the dose of 2.5 mg/kg. This same dose tended to decrease the time spent in the dark compartment, while at the same time increasing time spent in the light compartment of the light/dark transition model. Treatment with 5 mg/kg was without effect. No changes in locomotor activity were found. CBD also significantly decreased Fos-ir in different columns of the periaqueductal gray and in the dorsal region (DRD) and lateral wings (lwDR) of the DR. Tryptophan hydroxylase immunoreactivity was increased in the lwDR, DRD and ventral regions of the DR. Double immunostaining, however, was only increased in the lwDR, the main DR subnucleus associated to the modulation of panic-related responses, after treatment with CBD 2.5 mg.
Conclusions: These results suggest the efficacy of an oral lipid-based CBD nanoemulsion for the treatment of anxiety-related disorders and contribute to a better understanding of the behavioral and neurobiological effects of CBD in anxiety and panic.
Multi-domain Anomalous Relationships in Heterogeneous Temporal Data
Authors: Ale Tolulope , Janeja Vandana 
Published: December 2023

Abstract
The Arctic region is crucial to global climate stability. However, recent years have witnessed periods of extreme snow and ice melt, with rising temperatures that double the global average. These are not isolated events. They are the result of intricate interconnections across distinct domains. The challenge, therefore, lies not in understanding these individual domains, such as temperature, and radiation, but in decoding the inter-domain relationships inducing these polar anomalies. To address this, our study presents a novel framework aimed at mining these inter-domain relationships to explain such anomalies and the relationship across time series features comprehensively. These features may be selected from the same or different domains. Such anomalous relationships across features could help detect interesting phenomena such as extreme snow melt, and cloud cover and help identify time periods of interest when such relationships are more prevalent. We extracted the anomalous intervals in each domain using the Poisson Distribution model of rSatScan, then leveraged the concept of Direct Overlap and Proximity of anomalies to identify the direct and time-delayed temporal association (delayed correlation) between anomalies across features. The concept helps us understand how events in one domain may be associated with events in another domain during specific time periods using association rule mining. We evaluated our approach using ERA5 reanalysis data, and validated the identified anomalies against ground truth and evaluated the strength of the generated association rules using metrics like confidence and lift. Notably, several of our identified rules were consistent with findings confirmed by domain experts.
Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures
Authors: Amini Parshawn , Okeme Joseph 
Published: December 2023

Abstract
Purpose: Environmental exposure to hazardous chemicals have been linked to many detrimental health effects. It is critical to have effective biomonitoring methods to monitor the levels of these chemicals in humans to better evaluate key environmental exposures that increase the risk of chronic disease and death. Traditional biomonitoring utilizing blood and urine is limited due to the specialized skills and invasiveness of collecting these fluid samples. The systematic review focuses on the tear fluid, which is largely under-researched, as promising alternative to these traditional fluids. The objective is to evaluate the practicability of using human tear fluid for biomonitoring environmental exposures, highlighting potential pitfalls and opportunities.
Recent finding: Tear fluid biomonitoring represents a promising method for assessing exposures, as participants can conveniently collect tear fluid samples from the comfort of their home. Tear fluid uniquely interfaces with the external environment at the air-tear interface, providing a surface for airborne chemicals to diffuse into the ocular environment and interact with biomolecules. Tear fluid also contains molecules from the internal environment that have travelled from the blood to tears by crossing the blood-tear barrier. Our review shows that tear fluid can be used to identify hazardous chemicals from the external and environment environments and to differentiate between different exposure groups.
Summary: The review provides a critical analysis of the current state of knowledge in tear-based biomonitoring and draws attention to the promise of using the method for noninvasively increasing access to exposure assessment. The method will become acceptable for routine use as more individual and inter lab studies focus on broadly identifying and quantify exposure markers in tears, understanding factors that influence reliability of the method and standardizing the tear fluid method.
Theoretical Approaches in Russia to Understanding the Legal Nature of Legal Relations in the XIX – early XX Centuries: Historical and Legal Aspects
Authors: Andreev Yu. N. 
Published: December 2023

Relevance. As is known, legal relations play a significant role in law enforcement, legal protection, satisfaction of the vital interests of individuals and legal entities. The study of legal relations, the elucidation of their legal essence, role and place in the system of legal means remains an urgent problem in legal science, despite the long historical development of the doctrine of legal relations in the general theory of law and civil law. In modern jurisprudence, many researchers consider the concept of "legal relationship" as: public relations regulated by the rule of law; legal form of public (actual) relationship; the unity of the legal form and material content. The author of the article set the task to analyze in the historical and legal aspect the scientific views of Russian scientists on legal relations in the 19th early 20th centuries. in order to form their position on the designated topic.The purpose of the study: to find out in the historical and legal aspect the scientific views of Russian scientists of the 19th early 20th centuries. about legal relations, their subjective and object compositions, content.Research objectives: to identify the legal approaches of domestic researchers of law of the specified period to understanding the legal nature, subjects, objects and content of legal relations.Methodology. In the course of the study of the designated topic, such general scientific and private scientific research methods as historical-legal, logical, formal-legal, system-structural and comparative-legal methods were used.Results. Based on the analysis of the theoretical conclusions of well-known pre-revolutionary lawyers, it was revealed that a significant part of legal researchers considered legal relations as actual relations regulated by the norms of objective law, and the elements of legal relations are subjects, objects, legal rights and corresponding duties. It has been established that there are legal relations as ideal legal models of behavior of subjects of law, and specific legal relations that arise on the basis of legal facts with the participation of specific interested subjects of law, endowed with subjective rights and legal obligations regarding certain objects rights.Conclusions. Legal relations are social relations settled on the basis of the norms and principles of Russian law, reflecting the unity of the legal form and legal and factual content, with the participation of individuals and legal entities, public legal entities.
Going the Extra Mile: A Multisite Case Study of Two Private Schools in Pakistan
Authors: Gulab Fozia 
Published: December 2023

This study explored the perceptions of administrators, teachers and students of secondary schools in Karachi-Pakistan regarding the strategies adopted by the schools to exhibit care for the learning of students. This qualitative multisite case study was conducted with schools under the administration and management of Christians and Ismailies. A semi-structured interview guide was used as a tool for data collection purposes. The data were transcribed and coded for the construction of themes. Themes such as teacher preparation and performance, communication with parents, a learning-conducive environment, curricula supporting activities and continuous professional development were constructed from the data analysis. The study findings reveal that schools have adopted various strategies to facilitate and support students' learning. However, the primary focus seems to be on cognitive development, often at the expense of paying adequate attention to physical, social, and emotional development. Hence the study suggests that assumed and expressed needs of students in areas other than the cognitive domain should be considered pivotal by the school for a safe and peaceful society. The study also suggests that the application of care in a practical sense is the need of the times and should be made a systemic reality for all schools in Pakistan.
Identification Of Potential Hazards In Palm Oil Companies In The Sterilizer Section Using The HIRARC Method
Authors: Wahyudin Wahyudin , Sofiyanurriyanti Sofiyanurriyanti 
Published: December 2023

Worker safety is a critical factor in the continuity of an oil palm industry because the progress of the palm oil industry is also influenced by the availability of safety guarantees for its workers. Based on the results of the study, it was shown that the highest percentage of accident risk assessment was at the sterilizer work station (boiling FFB) using the HIRARC method, namely in the activity of pulling the cable sling from the winch and then attaching the hook to the lorry from the transfer carriage with 25 the risk of accidents occurring with a percentage of 33.33 % and categorized into extreme, for the second highest accident risk assessment, namely in the activity of pulling a lorry using a winch and in the activity of opening the sterilizer door and lowering the sterilizer bridge with a work accident risk of 16 times with a percentage rate of 21.33% and categorized into high incident and the risk of work accidents, namely in the activity of releasing the hook and carrying it then installing it to the last lorry and in the activity of pulling and carrying sling cables from the winch with a risk of accidents of 9 times the incidence of work accidents with a percentage rate of 12.00% and categorized into incident medium. Keywords: Minimizing the Risk of Occupational Accidents and the HIRARC Method