bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proximate Composition of Nappi and its way of marketing in Bangladesh
Authors: Monwar Md. Mostafa , Islam Md. Royhanur , Nirjar Sawmor Dey , Khan Mohammed Ashraful Azam , Alam Mohammed Shahidul , Ali Ataher , Ahmed Istiak 
Published: January 2024

Abstract
Nappi, fermented shrimp, a traditional diet, is widely consumed by the ethnic communities of Southeast Asian countries, especially in Bangladesh. The present study was carried out to determine the proximate composition of Nappi collected from two different places i.e., Moheshkhali and Chaufaldandi areas of Cox’s Bazar district, Bangladesh. The proximate composition of Nappi was varied from place to place depending on raw materials, preparation techniques and surrounding conditions of formulation places. Proximate composition includes moisture, protein, carbohydrate, fat and ash contents, amounting 37.66%, 34.93%, 1.39%, 8.53% and 17.49% respectively for the Moheshkhali and 35.44%, 37.43%, 2.66%, 6.0%, and 18.47% respectively for the Chaufaldandi sample. In the present study it is evident that moisture and fat content were higher in Moheshkhali sample whereas protein, carbohydrate and ash content were also higher in Chaufaldandi sample. Marketing strategy, Supply Channel, and Value Chain of Nappi were also analyzed. The findings of the study revealed that the good quality of Nappi relied on the fresh raw materials, hygienic condition of processing place and suitable techniques. Moreover, the good quality Nappi has a great market demand to the local ethnic communities in Bangladesh as well to the ethnic communities are living abroad. So, it is recommended to provide intervention on proper preparation techniques and marketing channels of Nappi.
The enhanced energy metabolism in the tumor margin mediated by RRAD promotes the progression of oral squamous cell carcinoma
Authors: Feng Zhien , Cheng Aoming , Xu Qiaoshi , Li Bo , Zhang Lirui , Wang Hao , Liu Chang , Han Zhengxue 
Published: January 2024

Abstract

The tumor margin as the invasive front has been proven to be closely related to the progression and metastasis of oral squamous cell carcinoma (OSCC). However, how tumor cells in the marginal region obtain the extra energy needed for tumor progression is still unknown. Here, we used spatial metabolomics and the spatial transcriptome to identify enhanced energy metabolism in the tumor margin of OSCC and identified that downregulation of Ras-related glycolysis inhibitor and calcium channel regulator (RRAD) in tumor cells mediated this process. The absence of RRAD enhanced the ingestion of glucose and malignant behaviors of tumor cells both in vivo and in vitro. Mechanically, the downregulation of RRAD promoted the internal flow of Ca2+ and hence elevated its concentration in the nucleus, which resulted in the activation of the CAMKIV-CREB1 axis to induce the transcription of the glucose transporter GLUT3. GLUT inhibitor-1, as an inhibitor of GLUT3, could suppress this vigorous energy metabolism and malignant behaviors caused by downregulation of RRAD. Taken together, our study revealed that enhanced energy metabolism in the tumor margin mediated by RRAD promotes the progression of OSCC and proved that GLUT3 is a potential target for future treatment of OSCC.
Evaluation of Online job Portals for HR Recruitment selection using AHP in Two Wheeler Automotive Industry– A case study
Authors: Murugesan Vadivel Senghazhani , Sunny Rohan 
Published: January 2024

Abstract

Automotive companies are booming worldwide in the economy. In order to sustain in the highly competitive world, every organization tries to create itself a trademark in the market. During the research, we looked at how two wheelers automotive company's selection and training system affected organizational performance, which together ensured the company's future growth. It ensures customer happiness, business performance, and the optimization of sales, purchasing, and logistical processes. In today's fast-paced, globally integrated world, human resources are one of the most important production variables. It is critical to preserve and improve economic competitiveness by properly selecting and developing these resources. The main aim of this study is to identify the best online job portal website for recruitment at Two Wheeler Company and to suggest an HR strategy which resonates company’s values and culture. Towards the end of the study, the researcher aims to design an efficient and effective HR strategy that can attract, engage and retain the top talent in the organization. A sample of 15 for selection of best online job portal for recruitment through proper questionnaires. Findings reveal that all the variables have a significant positive impact on the employer branding.
Social Media Analyses to Capture the Signs and Impacts of Fever Symptoms in Infants and Young Children
Authors: Smith Adam , Laughey William , Esclassan Frederic , Lodhi Imran 
Published: January 2024

Abstract

Purpose
Current efforts to tackle the challenges associated with managing child fevers have focused on developing an observer-report (ObsRO), the Paediatric Fever Distress Index (PFDI), which allows parents and caregivers the means to accurately recognize and treat child fevers. To further develop the PFDI, this study utilized online forums to evaluate parent-reported causes and symptoms of fever, the impact of these fevers on both children and parents, and to understand the means of parental management and diagnosis of child fevers.
Methods
Through analysis of social media and selected posts from the parental forum website Mumsnet.com, this study used natural language processing methods and a qualitative analytical approach to identify and analyze key themes relating to the study objectives in users’ posts.
Results
Gastrointestinal and respiratory symptoms were among the most frequently reported impacts of fever, whereas common causes were reported as vaccinations and viral infections. Approximately, half the parents and caregivers reported managing fever with antipyretic medication. Other parents and caregivers reported a significant emotional impact, feeling worried, scared, and panicked about their child’s fever.
Conclusion
This explorative study identified social media forums as being a rich source of information regarding parental behaviors and attitudes towards the identification and management of child fevers. Parental behaviors were varied, yet certain knowledge gaps identified the need for further education and future research into the management of fevers in children.
Clonal CD8 T Cells Accumulate in the Leptomeninges and Communicate with Microglia in Human Neurodegeneration
Authors: Elyaman Wassim , Hobson Ryan , Levy Samuel , Flaherty Delaney , Xiao Harrison , Ciener Benjamin , Reddy Hasini , Singal Chitra , Kim Christine , Teich Andrew F , Shneider Neil , Bradshaw Elizabeth 
Published: January 2024

Abstract
Murine studies have highlighted a crucial role for immune cells in the meninges in surveilling the central nervous system (CNS) and influencing neuroinflammation. However, how meningeal immunity is altered in human neurodegeneration and its effects on CNS inflammation is understudied. We performed the first single-cell analysis of the transcriptomes and T cell receptor (TCR) repertoire of 104,635 immune cells from 55 postmortem human brain and leptomeningeal tissues from donors with neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease. RNA and TCR sequencing from paired leptomeninges and brain allowed us to perform lineage tracing to identify the spatial trajectory of clonal T cells in the CNS and its borders. We propose that T cells activated in the brain emigrate to and establish residency in the leptomeninges where they likely contribute to impairments in lymphatic drainage and remotely to CNS inflammation by producing IFNγ and other cytokines. We identified regulatory networks local to the meninges including NK cell-mediated CD8 T cell killing which likely help to control meningeal inflammation. Collectively, these findings provide not only a foundation for future studies into brain border immune surveillance but also highlight important intercellular dynamics that could be leveraged to modulate neuroinflammation.
Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
Authors: Cofre Rodrigo , Castro Pablo , Tagliazucchi Enzo , Perl Yonathan Sanz , Naci Lorina , Owen Adrian , Sitt Jacobo , Destexhe Alain , Luppi Andrea 
Published: January 2024

Abstract

Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unconscious brain states in terms of whole-brain dynamics; in particular, that the maintenance of rich brain dynamics measured by entropy is a critical aspect of conscious awareness. Collectively, our results may have significant implications for our understanding of consciousness and the neural basis of human awareness, as well as for the discovery of robust signatures of consciousness that are generalizable among different brain conditions.
Effects of the heating strategy on the joint properties during infrared welding of polyamides
Authors: Gevers Karina , Schraa Lucas , Toews Paul , Decker Julia , Schöppner Volker , Uhlig Kai , Stommel Markus 
Published: January 2024

Abstract
In infrared welding, the heating phase is the phase offering the highest flexibility of choice regarding the process parameters. In this phase, the process parameters such as the heating time, emitter power and emitter component distance can be individually selected and combined with each other. The defined heating phases have a different influence on the joining components. In this work, the effects of four heating strategies and their influence on the resulting temperature distribution over the joining surface, the possible thermal material degradation, the morphology of the joining zone and the short-term tensile strength of the welded samples are investigated. In order to investigate the morphology, microsections are prepared which enable transmitted light microscopy of the black PA6 GF50 used. In summary, it can be concluded that different heating strategies have a different influence on the material even if the generated melt layer thickness is kept the same. Three of the four strategies result in material degradation on the joining surface. However, this has almost no effect on the resulting short-term strength of the weld. The results show that a high joining pressure compensates for the influence of the material damage by pressing the damaged material into the bead.
Reflections on the Saudi FDA Regulatory Experience with Smart GxP Inspections
Authors: Alhomaidan Ali M , Al-Murikhi Nawaf G. , Al-Qarni Morae A. , Fahaadi Fahad A. AL , Otaibi Khalid S. AL , Hafiz Radwan , Almadani Ohoud A. , Rafie Turki A. AL , Ageel Mohammed A. AL , Dahhas Mohammed A. 
Published: January 2024

Abstract
Smart GxP inspections have gained increasing attention due to the COVID-19 pandemic, which, understandably, made it challenging for regulatory authorities to conduct on-site inspections. Smart GxP inspections are an oversight approach developed by the SFDA to enable remote compliance assessments of establishments. In this type of inspection, appropriate technical methods and tools (such as livestreaming video) are used without requiring the presence of inspectors onsite, ensuring efficient utilization of resources and the efficiency of inspection process. The objective of this research is to examine and document the shared encounters involving remote inspections and evaluations carried out by SFDA from 2020 to 2022. This will be achieved through the evaluation of the accuracy of document evaluation and the extent to which the objectives of smart GxP inspections were met. Data were collected from local and international smart inspections reports conducted by SFDA between 2020 and 2022, covering medical device manufacturers, pharmaceutical manufacturing sites, warehouses, accreditation offices, scientific offices, and food manufacturing facilities. The results indicate that smart GxP inspections were effective in achieving visit objectives, showing a high degree of document evaluation accuracy. The findings of this study support the use of smart GxP inspections as a valuable alternative to on-site inspections, offering a practical solution to regulatory compliance during the pandemic and beyond. Although the SFDA recognizes the usefulness of smart inspections in upholding regulatory oversight in the face of various challenges, it does not endorse the complete replacement of conventional on-site inspection methods. The SFDA acknowledges significant limitations associated with the current technological resources used in remote regulatory assessments, and these limitations will be explored in the relevant sections.
Pseudomonas syringae pv. coronafaciens, causing a new bacterial halo blight disease on oat (Avena sativa L.) in China
Authors: Wang Jianjun , Zhang Ruochen , Chen Taixiang , Wei Xuekai , Kamran Malik , White James F , Zhao Guiqin , Li Chunjie 
Published: January 2024

Abstract

Pseudomonas syringae pv. coronafaciens (Ps-c) is a pathogenic bacterium species that can be found in agricultural environments that causes diseases in plants. During a survey in 2019–2020 of different areas, bacterial halo blight (BHB) caused by Ps-c in oat (Avena sativa L.) was observed in many oat fields in Huan county, Gansu Province of China. Average leaf disease incidence was approximately 1 to 14%. The symptoms of BHB were mainly observed on leaves of oat and appeared as white to yellow streaks. After 20–30 d, the streaks became yellow necrotic lesions and spread to whole leaves, eventually causing leaves to wilt and decline. Symptomatic leaves of affected oats were collected from locations to investigate the etiology of BHB disease, and a group of 32 bacterial isolates (HK7) phenotypically similar was consistently isolated from the necrotic lesion margins in all samples. Pathogenicity tests of this group isolates by wounding and injection inoculations in greenhouse demonstrated that the symptoms induced by them on oat were similar to those observed in the field. HK7 isolates were identified as Ps-c based on Biolog Gen III MicroStation, morphological, physiological and biochemical characterization, 16S rRNA and gyrB gene sequence analysis, which compared with a reference strain (Ps-c ATCC 19608). Furthermore, Ps-c had a narrow host range and was host specific. After inoculation of Ps-c on A. sativa (B7) and A. nuda (B2) in greenhouse, effective tillers, plant height, flag-leaf length, flag-leaf width, fresh weight, dry weight, panicle length, grains per spike, reproductive branches number and thousand grains weight of infected oat were averagely decreased by 19.44%, 11.49%, 11.34%, 9.23%, 11.61%, 7.57%, 6.11%, 9.73%, 9.31% and 4.15% compared with that of healthy oat, respectively. Therefore, BHB (Ps-c) is a new bacterial disease on oat in China and has negative influences on plant growth, forage and grain yield of oat, and these negative effects are enhanced with the increase of disease severity.
Nomogram-Based Prediction of the Risk of AVF Maturation :A Retrospective Study
Authors: Zhao Bin , Wang Hui , Wang YuZhu , Zhan Shen , Yu Pei 
Published: January 2024

Abstract

Objective: Early identification of autogenous arteriovenous fistula (AVF) maturation failure among end stage renal disease (ESRD) is crucial since it will likely allow early intervention to improve AVF maturation rate and shorten the duration of catheter usage. The aim of this study was to develop a nomogram for predicting AVF maturity in ESRD patients and explore the optimal timing of intervention for promaturity.
Methods: In this retrospective study, we assembled a retrospective cohort of 543 ESRD patients who had undergone AVF creation and routine follow-up at the Beijing Haidian Hospital (Haidian Section of Pecking University Third Hospital) between August 2018-and March 2022. A total of 532 subjects were randomly divided into the training cohort (389 cases) and the validation cohort (143 cases). In each cohort, the patients were divided into mature and non-mature groups according to whether arrived clinical or ultrasound criteria on three months after AVF creation. The timing of early intervention for non-maturation AVF was preliminarily discussed after a risk prediction nomogram for non-maturation in newly AVF creation was constructed.
Results: Among the total of 532 patients included, 379 (73.24%) of whom achieved fistula maturation at 3 months postoperatively. We randomly divided the total study population using computer-generated randomization into a training cohort (n=389) and a validation cohort (n=143) in approximately a 7:3 ratio. For the training cohort, our study found that the anastomotic diameter (anas1), internal diameter of the anastomotic vein(V1), and brachial artery blood flow (F1) at 1 month postoperatively were associated with the maturity. We generated a maturation nomogram in the training cohort (area under the curve [AUC], 0.938 [95% confidence interval {CI}, 0.908-0.967]; sensitivity 0.911; specificity 0.856) and validated the model in the validation cohort (AUC, 0.927 [95% CI,0.879-0.975]; sensitivity 0.870; specificity 0.886). The calibration curve showed optimal agreement between nomogram prediction and actual observation.
Conclusion: The nomogram can help clinicians identify the arteriovenous AVF maturation in ESRD patients. Our research also suggests that one month may be the optimal timing of non-maturity intervention for AVF.
Physics-informed two-tier neural network for non-linear model order reduction
Authors: Hong Yankun , Bansal Harshit , Veroy Karen 
Published: January 2024

Abstract

In recent years, machine learning (ML) has had a great impact in the area of non-intrusive, non-linear model order reduction (MOR). However, the offline training phase often still entails high computational costs since it requires numerous, expensive, full-order solutions as the training data. Furthermore, in state-of-the-art methods, neural networks trained by a small amount of training data cannot be expected to generalize sufficiently well, and the training phase often ignores the underlying physical information when it is applied with MOR. Moreover, state-of-the-art MOR techniques that ensure an efficient online stage, such as hyper reduction techniques, are either intrusive or entail high offline computational costs. To resolve these challenges, inspired by recent developments in physics-informed and physics-reinforced neural networks, we propose a non-intrusive, physics-informed, two-tier deep network (TTDN) method. The proposed network, in which the first tier achieves the regression of the unknown quantity of interest and the second tier rebuilds the physical constitutive law between the unknown quantities of interest and derived quantities, is trained using pretraining and semi-supervised learning strategies. To illustrate the efficiency of the proposed approach, we perform numerical experiments on challenging non-linear and non-affine problems, including multi-scale mechanics problems.
Modified Percutaneous Post-closure Technique for Bedside Weaning of Veno-arterial Extracorporeal Membrane Oxygenation
Authors: Xu Chen , Xu Guo-xiong , Cao Yi-fei , Chen Lei , Jin Yi-qi 
Published: January 2024

Abstract
Objectives
This study aimed to assess the safety and efficacy of a modified percutaneous post-closure technique for bedside arterial cannula removal of veno-arterial extracorporeal membrane oxygenation (VA-ECMO).
Materials:
Between December 2022 and August 2023, the data of all VA-ECMO patients weaned at our center were retrospectively reviewed. A modified post-closure technique with two ProGlide devices (Abbott Vascular, Santa Clara, CA) was adopted as a routine practice. The success of the technique was defined as achieving immediate hemostasis without a bailout open repair. The post-procedural complications included bleeding events, pseudoaneurysm, limb ischemia, distal embolization, and infection at the access site.
Results
Overall, nine patients were included in this study. The mean age was 69.7 ± 12.9 years with a male-to-female ratio of 2:1. The mean arterial sheath size was 16.7 ± 1.3 Fr. The mean duration of the procedure was 10.9 ± 2.2 min, and the mean length of stay in the intensive care unit after weaning was 16.2 ± 4.5 days. The efficacy of the technique achieved a success rate of 100%. A single patient (11.1%) developed minor bleeding, successfully managed with compression, and no more problems were observed following the procedure.
Conclusions
A modified post-closure technique was a feasible and safe strategy for VA-ECMO bedside weaning and may be considered an alternative option.
Effect of replacing ground corn with forage palm Nopalea cochenillifera on feed intake and digestibility, water intake, milk production and composition in Holstein x Zebu dairy cows.
Authors: SILVA REGINALDO MUNIZ DA , PIRES AURELIANO JOSÉ VIEIRA , SILVA FABIANO FERREIRA DA , NOGUEIRA MESSIAS DE SOUZA , JÚNIOR HERMÓGENES ALMEIDA DE SANTANA , ALVES GABRIELA DOS SANTOS 
Published: January 2024

Abstract

The aim of this study was to evaluate the consumption and digestibility of nutrients, production and composition of milk, and water intake of lactating dairy cows fed standard diets in which corn (M) was replaced by forage palm (PF). Eight Girolando cows (½ Holstein/Zebu blood), 3rd calf multiparous, with 60 to 80 days of lactation and an average weight of 450.0 ± 30.0 kg, were randomly distributed in a double Latin square (4x4). Four experimental diets were evaluated: (100% M + 0% PF), (66.6% M + 33.3% PF), (33.3% M + 66.6% PF) and (0% M + 100% PF). There was a difference (P<0.05) in the consumption of CP and EE (kg.day1), with a quadratic effect and a linear reduction, respectively, with substitution. The maximum CP consumption of 3.05 kg.day-1 was found at 46.07% and EE consumption fell by 3.81g for each percentage unit of palm added to the diet. There was a quadratic difference (P<0.05) for DM consumption in %PC and g.kg PC0,75, with maximum values of 3.97%PC and 186.8 g.kg PC0,75 with the substitution of 54.83 and 53.17%, respectively. There was a quadratic effect (P<0.05) for the consumption of NDF in %PC, with the maximum intake of 1.3% at the 74.69% substitution level. There was a linear reduction (P<0.05) in the digestibility of DM, NDF and NDT, and for the other nutrients there was no substitution effect (P>0.05). There was no difference (P>0.05) in milk production and composition. There was a linear reduction (P<0.05) in water intake. Forage palm can be used in a promising way to replace corn up to a level of 100% in the diet of lactating dairy cows.