bluuebunny/crossref_metadata_2025_split huggingface dataset:
ID2 promotes tumor progression and metastasis in thyroid cancer
Authors: Deng Zhongming , Xu Min , Ding Zhenghua , Kong Jianqiao , Liu Juanjuan , Zhang Zelin , Cao Ping 
Published: January 2024

Abstract
Background
Inhibitor of DNA Binding 2 (ID2) plays a crucial role in tumor cell proliferation, invasion, metastasis, and stemness. Aberrant ID2 expression is associated with poor prognosis in various cancers. However, the specific function of ID2 in thyroid cancer remain unclear.

Method
The TCGA database were utilized to explore the clinical relevance of ID2 in cancer. GO, KEGG, and TIMER were employed to predict the potential roles of ID2 in cancer. Functional analysis, including CCK-8, colony formation, transwell, wound healing, and sphere formation experiments, were conducted to determine the biological functions of ID2 in human cancers. Western blot (WB), RT-qPCR, and immunohistochemical (IHC) analyses were used to investigate the relationship between ID2 and downstream targets.

Results
Our study revealed significant overexpression of ID2 in various malignant tumor cells. Knocking ID2 significantly inhibited cancer cell proliferation and invasion, while overexpressing ID2 enhanced these capabilities. Additionally, ID2 mediates resistance of cancer cells to protein kinase B (or Akt) inhibitions. Further WB and IHC experiments indicated that ID2 promotes the phosphorylation activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, thereby upregulating the expression of downstream proliferation, epithelial-mesenchymal transition (EMT), and stemness-related markers.

Conclusion
We found that ID2 significantly promotes thyroid cancer cell proliferation, migration, EMT, and stemness through the PI3K/Akt pathway. Moreover, ID2 plays a crucial role in regulating cancer immune responses. It may serve as a potential biomarker for enhancing the efficacy of chemotherapy, targeted therapy, and immunotherapy against cancer.
What Do Supervisors’ and Supervisees’ Think About Mindfulness-Based Supervision? A Grounded Theory Study
Authors: Evans Alison , Griffith Gemma Maria , Smithson Janet 
Published: January 2024

Abstract
Objectives
Mindfulness-based supervision (MBS) is a vital support for teachers of mindfulness-based programmes (MBPs), and good practice guidance requires mindfulness teachers to have at least 4 hr of MBS a year. Despite this, underpinning theory and research on MBS is sparse. This study explores the perspectives of supervisors and supervisees to identify helpful and unhelpful processes within MBS.

Method
A total of 12 supervisors and supervisees participated. Two phases of semi-structured interviews took place, the first with all 12 and the second phase with a selected six participants. A conceptual model of how MBS affects the teaching of MBPs was developed using a constructivist grounded theory approach.

Results
All participants spoke of how MBS is a highly experiential way of developing skills to competently teach MBPs, supported through the relationship between supervisor and supervisee. MBS uses a mindfulness-based relational inquiry process characterised by specific ways of speaking, listening, and pausing. This inquiry supports the supervisee to cultivate an embodied way of knowing, a deliberate stance of “not knowing”, and to take an approach mode rather than avoidance mode towards vulnerability. During the interviews, participants emphasised the collaborative approach within MBS, but showed little acknowledgement or recognition of the inherent power with the role. Potential tensions in the holding of professional and ethical frameworks within MBS were identified.

Conclusions
Recommendations are made about how the key findings can be brought into the ongoing good practice within MBS. Future changes within MBS should address issues of bias, diversity, and inclusivity.
The importance of factors early in life for development of eating disorders in young people, with some focus on type 1 diabetes
Authors: Ludvigsson J. , Olsen Faresjö Å. 
Published: January 2024

Abstract
Aim
Eating disorders have a serious impact on quality of life, especially when combined with Type 1 diabetes. We investigated eating disorders in relation to factors early in life with some focus on Type 1 diabetes.

Methods
Out of 21,700 children born 1st of Oct 1997–1st of Oct 1999 17,055 (78.6%) were included in ABIS (All Babies in southeast Sweden) and 16,415 had adequate questionnaires. ICD-10 diagnosis from The National Patient Register was merged with the ABIS data.

Results
In total 247 individuals, 19 boys (7.7%) and 219 girls (92.3%) out of 16,415 (1.5%) developed eating disorders (EDs), 167 (1.0%) Type 1 diabetes of whom 7 (4.2%) also got eating disorders (ED) (OR 3.25 (1.47–7.28); p = 0.04), all of them years after diagnosis of Type 1 diabetes. EDs was associated with high parental education especially in fathers (OR 1.65 (1.09–2.50); p = 0.02) and to at birth anxiety, and depression among mothers. There was no association with the duration of breastfeeding.

Conclusions
Eating disorders are common in girls, with increased risk in high-educated but psychologically vulnerable families. Prevalence is increased in type 1 diabetes. Even modern diabetes treatment needs to be completed with psychological support.

Level of evidence
Level III: Evidence obtained from well-designed cohort or case–control analytic studies.
American politics in 3D: measuring multidimensional issue alignment in social media using social graphs and text data
Authors: Ramaciotti Pedro , Cassells Duncan , Vagena Zografoula , Cointet Jean-Philippe , Bailey Michael 
Published: January 2024

AbstractA growing number of social media studies in the U.S. rely on the characterization of the opinion of individual users, for example, as Democrat- or Republican-leaning, or in continuous scales ranging from most liberal to most conservative. Recent works have shown, however, that additional opinion dimensions, for instance measuring attitudes towards elites, institutions, or cultural change, are also relevant for understanding socio-informational phenomena on social platforms and in politics in general. The study of social networks in high-dimensional opinion spaces remains challenging in the US, both because of the relative dominance of a principal liberal-conservative dimension in observed phenomena, and because two-party political systems structure both the preferences of users and the tools to measure them. This article leverages graph embedding in multi-dimensional latent opinion spaces and text analysis to propose a method to identify additional opinion dimensions linked to cultural, policy, social, and ideological groups and preferences. Using Twitter social graph data we infer the political stance of nearly 2 million users connected to the political debate in the U.S. for several issue dimensions of public debate. We show that it is possible to identify several new dimensions structuring social graphs, non-aligned with the classic liberal-conservative dimension. We also show how the social graph is polarized to different degrees along these newfound dimensions, leveraging multi-modality measures in opinion space. These results shed a new light on ideal point estimation methods gaining attention in social media studies, showing that they cannot always assume to capture liberal-conservative divides in single-dimensional models.
Augustine on the Nature of Virtue and Sin
Authors: Chambers Katherine 
Published: January 2024

Augustine of Hippo is a key figure in the history of Christianity and has had a profound impact on the course of western moral and political thought. Katherine Chambers here explores a neglected topic in Augustinian studies by offering a systematic account of the meaning that Augustine gave to the notions of virtue, vice and sin. Countering the view that he broke with classical eudaimonism, she demonstrates that Augustine's moral thought builds on the dominant approach to ethics in classical 'pagan' antiquity. A critical appraisal of this tradition reveals that Augustine remained faithful to the eudaimonist approach to ethics. Chambers also refutes the view that Augustine was a political pessimist or realist, showing that it is based upon a misunderstanding of Augustine's ideas about the virtue of justice. Providing a coherent account of key features in Augustine's ethics, her study invites a new and fresh evaluation of his influence on western moral and political thought.
Paper waste grown as a biocalcified foam: perspectives from a bacterial and design viewpoint
Authors: Mosse Aurélie , Rennie Vincent , Poudoulec Quentin , Suárez Zamora Daniel 
Published: January 2024

Abstract
Biocalcification is a naturally occurring mineralisation phenomenon resulting from the urease produced by microorganisms inhabiting soil environments. This process, often referred to as microbially induced calcite precipitation (MICP), is primarily exploited in an engineering context for soil stabilisation and the repair of concrete structures. MICP represents an emerging area of research in architecture and design. In this paper, we discuss the appropriation of MICP on Papier Plume, a foam made of paper waste used in the context of ImpressioVivo: a design-led research project exploring the conception and fabrication of 3D-printed and bacterially induced bio-sourced materials for a circular design framework. In the light of a previous study based on two strategies of calcification: (1) direct inoculation (2) spraying, we – a team of two designers and a microbiologist – discuss the relevance of an immersion strategy applied to the dry paper foam substrate. By doing so, we reflect on the relevance of MICP as a material design process underpinned by sustainable and circularity concerns, from a design perspective, but also into an attempt to embrace the perspective of the bacteria supporting these experiments; namely Sporosarcina pasteurii.
Physics-informed artificial intelligence models for the seismic response prediction of rocking structures
Authors: Shen Shirley , Málaga-Chuquitaype Christian 
Published: January 2024

Abstract
The seismic response of a wide variety of structures, from small but irreplaceable museum exhibits to large bridge systems, is characterized by rocking. In addition, rocking motion is increasingly being used as a seismic protective strategy to limit the amount of seismic actions (moments) developed at the base of structures. However, rocking is a highly nonlinear phenomenon governed by non-smooth dynamic phases that make its prediction difficult. This study presents an alternative approach to rocking estimation based on a physics-informed convolutional neural network (PICNN). By training a group of PICNNs using limited datasets obtained from numerical simulations and encoding the known physics into the PICNNs, important predictive benefits are obtained relieving difficulties associated with over-fitting and minimizing the requirement for a large training database. Two models are created depending on the validation of the deep PICNN: the first model assumes that state variables including rotations and angular velocities are available, while the second model is useful when only acceleration measurements are known. The analysis is initiated by implementing K-means clustering. This is followed by a detailed statistical assessment and a comparative analysis of the response-histories of a rocking block. It is observed that the deep PICNN is capable of effectively estimating the seismic rocking response history when the rigid block does not overturn.
Ilmenau’s contributions to Design Science
Authors: Höhne Günter , Weber Christian , Husung Stephan 
Published: January 2024

Abstract
Ilmenau is a relatively small town in a beautiful landscape, close to the centre of Germany. Since 1894 it has been the home of a Technical College which after World War II and through some permutations became today’s Technische Universität Ilmenau. For 70 years the university has contributed to Design Science. It is interesting to note that the fundamentals were developed in practice, at the Carl Zeiss company in Jena; it was only later that the new ideas were further developed for academic research and teaching in Ilmenau. The origins at Zeiss Jena still account for the main application area at Technische Universität Ilmenau today: Precision Engineering which, in addition to mechanical, has always included electric, electronic, control, software, and even optical components (“mechatronics” before the term was coined). This article – written by three (out of four in total) of the professors who were and are, respectively, in charge over almost 50 out of the 70 years – tells the story of Design Science in Ilmenau: background, beginnings, development, contributions to research, teaching, and transfer to industry. As Ilmenau was situated in the German Democratic Republic (“East Germany”) between 1949 and 1990, the story is not free of political and societal implications, some of them quite surprising.
The limits of currency politics
Authors: Lapavitsas Costas 
Published: January 2024

AbstractIn Locke’s philosophy money is ‘naturalised’ and thus ostensibly removed from political contestation. Locke has been criticised for marginalising monetary politics, and thus downplaying the conventional character of money that could potentially allow for democratic monetary reform. Drawing on Marx’s writings, this paper shows that money is indeed a social convention, but its inherent economic functioning restricts its susceptibility to political contestation. There are limits to the democratic reform of money in a capitalist economy that spring from money’s own nature.Specifically, the politics of money is rooted in the tension between money as measure of value and money as unit of account. The state draws political power from setting the unit of account, but the measurement of value occurs spontaneously among commodity producers, thereby generating tension that curbs monetary politics. In contemporary conditions, this is typified by central banks having the freedom to manage the unit of account but subject to heavy economic constraints rooted in value measurement. In this light, democratic monetary reform requires restricting the spontaneous measurement of value, thus intervening at the heart of the capitalist economy. For money to be democratic it needs to have a much narrower range of economic functioning.
Eastward across the Western Sea: The Indian Oceanic Trafficking of Africans into China
Authors: Wyatt Don J. 
Published: January 2024

AbstractDespite its greater extensiveness in comparison to the ferrying of their West African counterparts across the Atlantic Ocean into bondage in the New World, the history of the extraction of East Africans to serve as slaves in the various lands that ring the Indian Ocean is barely known to most of us. Particularly as Westerners, our knowledge of even the sketchiest outlines of the latter phenomenon pales before what we know intimately about the intricacies of the former. Furthermore, unknown altogether to too many is the fact that—from at least as early as the eighth century of the Common Era—these East African slaves were exported as distantly as China. Based principally on the pertinent Chinese sources, this study raises and investigates three fundamental questions concerning this conveyance of East Africans into China. First, who were the original enslavers of these East Africans and thus the prime purveyors of their entrance over the centuries into bondage in China? Second, how—that is, by land or by sea—and under what auspices were these East Africans typically transported from their homelands mainly along the eastern African coastline to a locale as far away as China? Third and finally, what was the probable fate of these East Africans once they had arrived in China? The essay concludes with a consideration of the consequentiality of this largely overlooked and therefore unheralded saga amidst the history of Chinese institutionalised servitude overall.
Neural correlates of compound head position in language control: Evidence from simultaneous production and comprehension
Authors: Liu Shuang , Huang Junjun , Xing Zehui , Schwieter John W. , Liu Huanhuan 
Published: January 2024

Abstract
Compound words consist of two or more words which combine to form a single word or phrase that acts as one. In English, the head of compound words is usually, but not always, the right-most root (e.g., “paycheck” is a noun because the head, “check,” is a noun). The current study explores the effects of head position on language control by examining language switching performance through electroencephalography (EEG). Twenty-one pairs of Chinese (L1)–English (L2) bilinguals performed cued language switching in a simultaneous production and comprehension task. The results showed that bilinguals recognized the head position earlier both in production and comprehension. However, the language control of the head position during production occurred in the middle stage (N2), but in the late stage (LPC) during comprehension. These findings indicate that the head position in compound words exerts differential influences on language control.
Deep Mantle Component and Continental Crust Remobilization in the Source of Vesteris Seamount, East Greenland Margin
Authors: Beloša L. , Callegaro S. , Meyzen C. M. , Gaina C. , Polteau S. , Bizimis M. , Mazzini A. 
Published: January 2024

AbstractVesteris Seamount is a large Quaternary intraplate submarine volcano in the SW Greenland Sea, about 1,000 km NE of Iceland and 300 km NW of the Mohn's spreading ridge, whose mode of formation remains unsolved. We present geochemical data for new samples dredged from the Vesteris edifice, including major, trace elements and Sr‐Nd‐Pb‐Hf isotopes. The isotopic characteristics of the alkaline lavas, covering the basanite/tephrite to benmoreite range, indicate the involvement of depleted and enriched mantle components. The source is dominated by the depleted mantle (85%–90%) and a deep enriched component possibly supplied by the Iceland Plume (IP) (10%–15%). Additional source enrichment was due to recycled crust and sub‐continental lithospheric mantle, as suggested by Hf isotopes (0.283147 ± 0.000005) measured for the first time in Vesteris lavas and by a decoupling in Pb isotopes evidenced by relatively low‐radiogenic 207Pb/204Pb (15.510) and high‐radiogenic 208Pb/204Pb (38.554) with respect to the Northern Hemisphere Reference Line. We interpret the geochemical results using existing knowledge about the regional lithospheric and upper mantle structure. Our findings suggest that a deep (ca. 420–320 km) mantle anomaly, with seismological characteristics of the Iceland mantle plume, extends from East Greenland to the north of Jan Mayen Fracture Zone. The regional lithospheric thinning toward the Greenland Basin enabled the melting events that produced the Vesteris seamount. This lateral NNE‐directed flow lobe of the Iceland plume may have carved and transferred enriched components from the continental lithospheric margin of Greenland north of Scoresby Sund toward the Vesteris source.
Crustal and Uppermost Mantle Azimuthal Seismic Anisotropy of Antarctica From Ambient Noise Tomography
Authors: Zhou Zhengyang , Wiens Douglas A. , Nyblade Andrew A. , Aster Richard C. , Wilson Terry , Shen Weisen 
Published: January 2024

AbstractSeismic anisotropy provides essential information for characterizing the orientation of deformation and flow in the crust and mantle. The isotropic structure of the Antarctic crust and upper mantle has been determined by previous studies, but the azimuthal anisotropy structure has only been constrained by mantle core phase (SKS) splitting observations. This study determines the azimuthal anisotropic structure of the crust and mantle beneath the central and West Antarctica based on 8—55 s Rayleigh wave phase velocities from ambient noise cross‐correlation. An anisotropic Rayleigh wave phase velocity map was created using a ray—based tomography method. These data are inverted using a Bayesian Monte Carlo method to obtain an azimuthal anisotropy model with uncertainties. The azimuthal anisotropy structure in most of the study region can be fit by a two‐layer structure, with one layer at depths of 0–15 km in the shallow crust and the other layer in the uppermost mantle. The azimuthal anisotropic layer in the shallow crust of West Antarctica, where it coincides with strong positive radial anisotropy quantified by the previous study, shows a fast direction that is subparallel to the inferred extension direction of the West Antarctic Rift System. Fast directions of upper mantle azimuthal anisotropy generally align with teleseismic shear wave splitting fast directions, suggesting a thin lithosphere or similar lithosphere‐asthenosphere deformation. However, inconsistencies in this exist in Marie Byrd Land, indicating differing ancient deformation patterns in the shallow mantle lithosphere sampled by the surface waves and deformation in the deeper mantle and asthenosphere sampled more strongly by splitting measurements.
Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD
Authors: Blalock Zachary N. , Wu Gwyneth W. Y , Lindqvist Daniel , Trumpff Caroline , Flory Janine D. , Lin Jue , Reus Victor I. , Rampersaud Ryan , Hammamieh Rasha , Gautam Aarti ,   SBPBC, Ressler Kerry J. , Yang Ruoting , Muhie Seid , Daigle Bernie J. , Bierer Linda M. , Hood Leroy , Wang Kai , Lee Inyoul , Dean Kelsey R. , Somvanshi Pramod R. , Doyle Francis J. , Marmar Charles R. , Jett Marti , Yehuda Rachel , Wolkowitz Owen M. , Mellon Synthia H. 
Published: January 2024

AbstractCirculating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatric disorders. No studies have yet analyzed ccf-mtDNA levels in post-traumatic stress disorder (PTSD), despite evidence of mitochondrial dysfunction in this condition. In the current study, we compared plasma ccf-mtDNA levels in combat trauma-exposed male veterans with PTSD (n = 111) with those who did not develop PTSD (n = 121) and also investigated the relationship between ccf mt-DNA levels and glucocorticoid sensitivity. In unadjusted analyses, ccf-mtDNA levels did not differ significantly between the PTSD and non-PTSD groups (t = 1.312, p = 0.191, Cohen’s d = 0.172). In a sensitivity analysis excluding participants with diabetes and those using antidepressant medication and controlling for age, the PTSD group had lower ccf-mtDNA levels than did the non-PTSD group (F(1, 179) = 5.971, p = 0.016, partial η2 = 0.033). Across the entire sample, ccf-mtDNA levels were negatively correlated with post-dexamethasone adrenocorticotropic hormone (ACTH) decline (r = −0.171, p = 0.020) and cortisol decline (r = −0.149, p = 0.034) (viz., greater ACTH and cortisol suppression was associated with lower ccf-mtDNA levels) both with and without controlling for age, antidepressant status and diabetes status. Ccf-mtDNA levels were also significantly positively associated with IC50-DEX (the concentration of dexamethasone at which 50% of lysozyme activity is inhibited), a measure of lymphocyte glucocorticoid sensitivity, after controlling for age, antidepressant status, and diabetes status (β = 0.142, p = 0.038), suggesting that increased lymphocyte glucocorticoid sensitivity is associated with lower ccf-mtDNA levels. Although no overall group differences were found in unadjusted analyses, excluding subjects with diabetes and those taking antidepressants, which may affect ccf-mtDNA levels, as well as controlling for age, revealed decreased ccf-mtDNA levels in PTSD. In both adjusted and unadjusted analyses, low ccf-mtDNA levels were associated with relatively increased glucocorticoid sensitivity, often reported in PTSD, suggesting a link between mitochondrial and glucocorticoid-related abnormalities in PTSD.