bluuebunny/crossref_metadata_2025_split huggingface dataset:
AstroYOLO: A hybrid CNN–Transformer deep-learning object-detection model for blue horizontal-branch stars
Authors: He Yuchen , Wu Jingjing , Wang Wenyu , Jiang Bin , Zhang Yanxia 
Published: October 2023

Abstract
Blue horizontal-branch stars (BHBs) are ideal tracers for studying the Milky Way (MW) due to their bright and nearly constant magnitude. However, an incomplete screen of BHBs from a survey would result in bias of estimation of the structure or mass of the MW. With surveys of large sky telescopes like the Sloan Digital Sky Survey (SDSS), it is possible to obtain a complete sample. Thus, detecting BHBs from massive photometric images quickly and effectually is necessary. The current acquisition methods of BHBs are mainly based on manual or semi-automatic modes. Therefore, novel approaches are required to replace manual or traditional machine-learning detection. The mainstream deep-learning-based object-detection methods are often vanilla convolutional neural networks whose ability to extract global features is limited by the receptive field of the convolution operator. Recently, a new Transformer-based method has benefited from the global receptive field advantage brought by the self-attention mechanism, exceeded the vanilla convolution model in many tasks, and achieved excellent results. Therefore, this paper proposes a hybrid convolution and Transformer model called AstroYOLO to take advantage of the convolution in local feature representation and Transformer’s easier discovery of long-distance feature dependences. We conduct a comparative experiment on the 4799 SDSS DR16 photometric image dataset. The experimental results show that our model achieves 99.25% AP@50, 93.79% AP@75, and 64.45% AP@95 on the test dataset, outperforming the YOLOv3 and YOLOv4 object-detection models. In addition, we test on larger cutout images based on the same resolution. Our model can reach 99.02% AP@50, 92.00% AP@75, and 61.96% AP@95 respectively, still better than YOLOv3 and YOLOv4. These results also suggest that an appropriate size for cutout images is necessary for the performance and computation of object detection. Compared with the previous models, our model has achieved satisfactory object-detection results and can effectively improve the accuracy of BHB detection.
Vascularization ability of glioma stem cells in different three-dimensional microenvironments
Authors: Wang Xuanzhi , Xu Tao , Niu Chaoshi 
Published: October 2023

Abstract
Glioblastoma (GBM) is among the most common and aggressive adult central nervous system tumors. One prominent characteristic of GBM is the presence of abnormal microvessels. A significant correlation between angiogenesis and prognosis has been observed. Accurately reconstructing this neovascularization and tumor microenvironment through personalized in vitro disease models presents a significant challenge. However, it is crucial to develop new anti-angiogenic therapies for GBM. In this study, 3D bioprinted glioma stem cell (GSC)-laden hydrogel scaffolds, hybrid GSC hydrogels and cell-free hydrogel scaffolds were manufactured to investigate the vascularization ability of GSCs in varying 3D microenvironments. Our results demonstrated that the bioactivity of GSCs in the 3D bioprinted GSC-laden hydrogel scaffold was preferable and stable, and the amounts of vascular endothelial growth factor A and basic fibroblast growth factor were the highest in the microenvironment. When the three different models were co-cultured with human umbilical vein endothelial cells, the expression of angiogenesis-related markers was the most abundant in the bioprinted GSC-laden hydrogel scaffold. Additionally, xenograft tumors formed by bioprinted GSC-laden hydrogel scaffolds more closely resembled human gliomas regarding color, texture and vascularization. Notably, in xenograft tumors derived from 3D bioprinted GSC-laden hydrogel scaffolds, the number of human CD105+ cells was significantly higher, and human endothelial vascular lumen-like structures were observed. This indicates that the 3D bioprinted GSC-laden hydrogel scaffold is a suitable model for mimicking the glioma microenvironment and studying tumor angiogenesis.
Glycolysis: A fork in the path of normal and pathological pregnancy
Authors: Gou Rui , Zhang Xiaohong 
Published: October 2023

AbstractGlucose metabolism is vital to the survival of living organisms. Since the discovery of the Warburg effect in the 1920s, glycolysis has become a major research area in the field of metabolism. Glycolysis has been extensively studied in the field of cancer and is considered as a promising therapeutic target. However, research on the role of glycolysis in pregnancy is limited. Recent evidence suggests that blastocysts, trophoblasts, decidua, and tumors all acquire metabolic energy at specific stages in a highly similar manner. Glycolysis, carefully controlled throughout pregnancy, maintains a dynamic and coordinated state, so as to maintain the homeostasis of the maternal–fetal interface and ensure normal gestation. In the present review, we investigate metabolic remodeling and the selective propensity of the embryo and placenta for glycolysis. We then address dysregulated glycolysis that occurs in the cellular interactive network at the maternal–fetal interface in miscarriage, preeclampsia, fetal growth restriction, and gestational diabetes mellitus. We provide new insights into the field of maternal–fetal medicine from a metabolic perspective, thus revealing the mystery of human pregnancy.
Single-cell transcriptome analysis reveals the key genes associated with macrophage polarization in liver cancer
Authors: Ding Zhenghua , Deng Zhongming , Li Hengping 
Published: October 2023

Background:
The aim of this study was to reveal the key genes associated with macrophage polarization in liver cancer.

Methods:
Data were downloaded from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas databases (TCGA). R package Seurat 4.0 was used to preprocess the downloaded single-cell sequencing data, principal component analysis, and clustering. R package SingleR was used to annotate cell types and calculate macrophage polarization scores. Spearman correlation analysis was performed to obtain key genes highly correlated with macrophage polarization in liver cancer. The Tumor IMmune Estimation Resource algorithm was used to analyze the correlation between genes and the infiltration level of macrophages. Finally, the prognostic model was constructed based on 6 macrophage polarization-related genes by multivariate Cox regression analysis. Kaplan-Meier curves and receiver operating characteristic curves validated the prognostic value of the prognostic model.

Results:
Two thousand highly variable genes were obtained after the normalization of single-cell profiles. In all, 16 principal components and 15 cell clusters were obtained. Monocytes and macrophages were the main immune cells in the microenvironment of liver cancer tissues. Macrophage polarization scores showed that cluster 5 had the highest degree of polarization. Spearman analysis yielded that a total of 6 key genes associated with macrophage polarization (CD53, TGFBI, S100A4, pyruvate kinase M, LSP1, SPP1), and Tumor IMmune Estimation Resource analysis showed that 6 key genes were significantly positively correlated with macrophage infiltration levels. The model constructed by 6 key genes could effectively evaluate the prognosis of patients with liver cancer.

Conclusions:
The key genes associated with macrophage polarization, namely CD53, TGFBI, S100A4, pyruvate kinase M, LSP1, and SPP1, may be potential therapeutic targets for liver cancer.
Main Mechanisms of Remote Monitoring Programs for Cardiac Rehabilitation and Secondary Prevention
Authors: Clark Alexander M. , Sousa Bailey J. , Ski Chantal F. , Redfern Julie , Neubeck Lis , Allana Saleema , Peart Annette , MacDougall Danielle , Thompson David R. 
Published: October 2023

Purpose:
The objective of this report was to identify the main mechanisms of home-based remote monitoring programs for cardiac rehabilitation (RM CR) and examine how these mechanisms vary by context.

Methods:
This was a systematic review using realist synthesis. To be included, articles had to be published in English between 2010 and November 2020 and contain specific data related to mechanisms of effect of programs. MEDLINE All (1946-) via Ovid, Embase (1974-) via Ovid, APA PsycINFO (1806-), CINAHL via EBSCO, Scopus databases, and gray literature were searched.

Results:
From 13 747 citations, 91 focused on cardiac conditions, with 23 reports including patients in CR. Effective RM CR programs more successfully adapted to different patient home settings and broader lives, incorporated individualized patient health data, and had content designed specifically for patients in cardiac rehabilitation. Relatively minor but common technical issues could significantly reduce perceived benefits. Patients and families were highly receptive to the programs and viewed themselves as fortunate to receive such services. The RM CR programs could be improved via incorporating more connectivity to other patients. No clear negative effects on perceived utility or outcomes occurred by patient age, ethnicity, or sex. Overall, the programs were seen to best suit highly motivated patients and consolidated rather than harmed existing relationships with health care professionals and teams.

Conclusions:
Remote monitoring CR programs are perceived by patients to be beneficial and attractive. Future RM CR programs should consider adaptability to different home settings, incorporate individualized health data, and contain content specific to patient needs.
Mindfulness-Based Self-Care for Forensic Nurses: A Professional Lifestyle Approach
Authors: Bhattarai Muna , Clements Paul Thomas , Downing Nancy R. 
Published: October 2023

ABSTRACT
Forensic nurses providing care to patients who are victims or offenders of abuse, trauma, or violence often face enormous challenges in their daily practice, leading to emotional stress, vicarious traumatization, and burnout, and potentially reducing the quality of patient care. Embracing mindfulness as an ongoing method of self-care can have an array of benefits for forensic nurses to prevent burnout and improve their well-being and quality of patient care. Existing literature supports the benefits of mindfulness-based interventions, as self-care practices, in improving many positive health outcomes among nurses working in a variety of healthcare settings. Mindfulness qualities, such as open awareness, attention to detail, nonjudgment, emotional regulation, compassion, and empathy, can contribute to forensic nurses' well-being and the quality of patient care. Mindfulness is a way of living; thus, formal and informal mindful self-care tools integrated into daily nursing practice can result in better outcomes and work satisfaction among nurses. This article discusses the potential benefits of mindfulness and practical ways to integrate mindfulness tools into forensic nursing practice. Incorporating mindful self-care practices should be a goal for consideration for the contemporary forensic nursing profession at large. Further intervention research is recommended to identify the mechanism of how mindfulness can benefit forensic nurses practicing in highly challenging work environments.
Novel pharmacological interventions for diabetic kidney disease
Authors: Tan Seng Kiong , Pinzon-Cortes Jairo A. , Cooper Mark E. 
Published: October 2023

Purpose of review
The purpose of this review is to summarize the latest evidence on the prevention and progression of diabetic kidney disease (DKD), as well as novel pharmacological interventions from preclinical and early clinical studies with promising findings in the reduction of this condition's burden.

Recent findings
We will cover the latest evidence on the reduction of proteinuria and kidney function decline in DKD achieved through established renin-angiotensin-aldosterone system (RAAS) system blockade and the more recent addition of SGLT2i, nonsteroidal mineralocorticoid receptor antagonists (MRAs) and GLP1-RA, that combined will most likely integrate the mainstay for current DKD treatment. We also highlight evidence from new mechanisms of action in DKD, including other haemodynamic anti-inflammatory and antifibrotic interventions, oxidative stress modulators and cell identity and epigenetic targets.

Summary
Renal specific outcome trials have become more popular and are increasing the available armamentarium to diminish the progression of renal decline in patients at greater risk of end-stage kidney disease (ESKD) such as diabetic individuals. A combined pharmaceutical approach based on available rigorous studies should include RAAS blockade, SGLT2 inhibitors, nonsteroidal MRA and expectedly GLP1-RA on a personalized based-intervention. New specific trials designed to address renal outcomes will be needed for innovative therapies to conclude on their potential benefits in DKD.
Comparing Repeatability and Agreement between Commonly Used Corneal Imaging Devices in Keratoconus
Authors: Angelo Lize , Gokul Akilesh , McGhee Charles , Ziaei Mohammed 
Published: October 2023

SIGNIFICANCE
Keratometry and pachymetry are important for diagnosis and monitoring of keratoconus. Many corneal imaging units exist, but comparison to determine repeatability and agreement is paramount for adequate keratoconus management in primary and secondary care.

PURPOSE
This study aimed to evaluate the repeatability and agreement of a Placido disc–based videokeratoscope (Melbourne, Victoria, Australia) used in primary care with spectral-domain optical coherence tomography (Optopol Technology, Zawiercie, Poland) and Scheimpflug corneal tomography (Oculus, Wetzlar, Germany) in secondary care.

METHODS
This was a prospective single-center study where one eye was randomized to have central corneal thickness;thinnest corneal thickness (TCT); and maximum, mean, steep, and flat keratometry (Kmax, Kmean, Ksteep, and Kflat, respectively), measured with all three devices. Three measurements were completed per device to assess intraobserver repeatability.

RESULTS
A total of 110 eyes from 110 patients with keratoconus were analyzed. Repeatability was best with the Pentacam for central corneal thickness, Kmax, Kmean, Ksteep, and Kflat parameters (precision, 9.21, 0.8, 0.38, 0.52, and 0.58). The Medmont had better repeatability than the Revo with Kmax, Kmean, Ksteep, and Kflat (precision, 1.41,1.35,1.43, and 1.59). Revo had the best repeatability with TCT (precision, 3.81). The intraclass correlation coefficient was >0.94 for all parameters in all devices. Agreement was generally poor between devices. However, there was good agreement between Pentacam and Medmont Kflat measurements (P > .05).

CONCLUSIONS
Repeatability of keratometry parameters with the Pentacam and Medmont was greater than the Revo, suggesting a lower threshold for detecting change in anterior corneal parameters. The Revo had the greatest repeatability for TCT, suggesting a lower threshold for detecting thinning in disease progression and corneal-crosslinking safety. There was poor agreement between devices, and it is not recommended for them to be used interchangably.
Case Report: Role of Anterior Segment Optical Coherence Tomography for Managing Failed Endothelial Keratoplasty Graft
Authors: Roig-Revert María José , Arias-García Elena , Ortega-Pérez Carolina , Peris-Martínez Cristina 
Published: October 2023

SIGNIFICANCE
Some patients show poor visual outcomes after Descemet stripping automated endothelial keratoplasty. In such cases, secondary Descemet membrane endothelial keratoplasty can be performed to achieve complete visual recovery. Anterior segment optical coherence tomography (AS-OCT) is a valuable tool for the follow-up of posterior lamellar keratoplasty outcomes and complications.

PURPOSE
This study aimed to report the clinical outcome of secondary Descemet membrane endothelial keratoplasty for managing poor visual results in a patient with graft failure after a previous Descemet stripping automated endothelial keratoplasty, highlighting the importance of AS-OCT in the follow-up of endothelial keratoplasty.

CASE REPORT
A 38-year-old woman with high myopia underwent Descemet stripping automated endothelial keratoplasty for bullous keratopathy after explantation of an angle-supported phakic intraocular lens. Two years after keratoplasty, the patient experienced poor visual acuity (counting fingers), and significant corneal edema was observed on clinical examination hindering visualization of the anterior chamber structures. Anterior segment optical coherence tomography showed a failed and thickened graft adhering well to the recipient cornea in an anterior chamber without other comorbidities. Therefore, the graft was removed and replaced with a Descemet membrane endothelial keratoplasty graft without any complications. One year later, the clinical outcome was evaluated by comparing the pre-operative and post-operative best-corrected visual acuity, biomicroscopy findings, endothelial cell density, and corneal central thickness.

CONCLUSIONS
Anterior segment optical coherence tomography is an important tool when deciding on the surgical technique to be applied and for the post-surgical monitoring of endothelial corneal grafts. This case demonstrates the successful management of Descemet stripping automated endothelial keratoplasty graft failure with Descemet membrane endothelial keratoplasty graft, highlighting the importance of AS-OCT in detecting complications such as graft dislocation and primary graft failure. In addition, corneal thickness measured using AS-OCT serves as a critical predictor of graft failure, as observed in this case.
Large lessons learned from small vessels: coronary microvascular dysfunction in HIV
Authors: Thomas Teressa S. , Walpert Allie R. , Srinivasa Suman 
Published: October 2023

Purpose of review
Large cohort studies have consistently shown the presence of heart failure is approximately doubled among persons with HIV (PWH). Early studies of cardiovascular disease (CVD) in HIV were primarily focused on atherosclerotic burden, and we now have a greater understanding of large vessel disease in HIV. More recent studies have begun to inform us about small vessel disease, or coronary microvascular dysfunction (CMD), in HIV. CMD is recognized to be an important risk factor for adverse events related to heart failure, associated with cardiovascular mortality, and often presents without overt atherosclerotic disease.

Recent findings
In this review, we highlight implications for CMD and relevant clinical studies in HIV. Inflammation and endothelial dysfunction, well known risk factors in HIV, may mediate the pathogenesis of CMD. Initial studies suggest that CMD worsens with ART initiation. Newer studies reveal CMD is present among well treated PWH without known CVD. In addition, myocardial flow reserve (MFR), a marker of CMD, is reduced in HIV similar to diabetes. There also appears to be sex differences, such that CMD is worse among women vs. men with HIV.

Summary
Alterations in the coronary microvasculature may be an important mediator of subclinical myocardial dysfunction that deserves further clinical attention among PWH without known CVD.
Electrical stimulation of the peripheral and central vestibular system
Authors: Lopez Christophe , Cullen Kathleen E. 
Published: October 2023

Purpose of review
Electrical stimulation of the peripheral and central vestibular system using noninvasive (galvanic vestibular stimulation, GVS) or invasive (intracranial electrical brain stimulation, iEBS) approaches have a long history of use in studying self-motion perception and balance control. The aim of this review is to summarize recent electrophysiological studies of the effects of GVS, and functional mapping of the central vestibular system using iEBS in awake patients.

Recent findings
The use of GVS has become increasingly common in the assessment and treatment of a wide range of clinical disorders including vestibulopathy and Parkinson's disease. The results of recent single unit recording studies have provided new insight into the neural mechanisms underlying GVS-evoked improvements in perceptual and motor responses. Furthermore, the application of iEBS in patients with epilepsy or during awake brain surgery has provided causal evidence of vestibular information processing in mostly the middle cingulate cortex, posterior insula, inferior parietal lobule, amygdala, precuneus, and superior temporal gyrus.

Summary
Recent studies have established that GVS evokes robust and parallel activation of both canal and otolith afferents that is significantly different from that evoked by natural head motion stimulation. Furthermore, there is evidence that GVS can induce beneficial neural plasticity in the central pathways of patients with vestibular loss. In addition, iEBS studies highlighted an underestimated contribution of areas in the medial part of the cerebral hemispheres to the cortical vestibular network.
Pacificoceanicola onchidii gen. nov., sp. nov., isolated from a marine invertebrate from the South China Sea
Authors: Yang Peng , Liang Jinyou , Yin Qi , Li Guanbin , Zhang Yu , Xu Ying , Hao Lingyun 
Published: October 2023

A Gram-stain-negative, facultative anaerobic, non-flagellated and oval-shaped (0.77–0.98 µm wide and 0.74–1.21 µm long) bacterial strain, designated XY-301T, was isolated from a marine invertebrate collected from the South China Sea. Strain XY-301T grew at 15–37 °C (optimum, 30–35 °C) and at pH 7.0–8.5 (optimum, pH 8.0). The strain was slightly halophilic and it only grew in the presence of 0.5–6.5 % (w/v) NaCl (optimum, 2.5–3.5 %). Its predominant fatty acid (>10 %) was C18 : 1
ω7c. The predominant polar lipids of XY-301T were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, six unidentified aminolipids, three unidentified phospholipids and two unknown polar lipids. The respiratory quinone was Q-10. The genome of XY-301T was 4 979 779 bp in size, with a DNA G+C content of 61.3 mol%. The average nucleotide identity, digital DNA–DNA hybridization and average amino acid identity values between XY-301T and

Pseudoprimorskyibacter insulae

SSK3-2T were 73.3, 14.5 and 53.5 %, respectively. Based on the results of phylogenetic, phenotypic, chemotaxonomic and genomic analyses, strain XY-301T is considered to represent a novel species and a new genus of the family

Roseobacteraceae

, for which the name Pacificoceanicola onchidii gen. nov., sp. nov. is proposed. The type strain is XY-301T (=KCTC 72212T=MCCC 1K03614T).
G protein activation occurs via a largely universal mechanism
Authors: Vithani Neha , Todd Tyson D. , Singh Sukrit , Blumer Kendall J. , Bowman Gregory R. 
Published: October 2023

AbstractUnderstanding how signaling proteins like G proteins are allosterically activated is a long-standing challenge with significant biological and medical implications. Because it is difficult to directly observe such dynamic processes, much of our understanding is based on inferences from a limited number of static snapshots of relevant protein structures, mutagenesis data, and patterns of sequence conservation. Here, we use computer simulations to directly interrogate allosteric coupling in six G protein α-subunit isoforms covering all four G protein families. To analyze this data, we introduce automated methods for inferring allosteric networks from simulation data and assessing how allostery is conserved or diverged among related protein isoforms. We find that the allosteric networks in these six G protein α-subunits are largely conserved and consist of two pathways, which we call pathway-I and pathway-II. This analysis predicts that pathway-I is generally dominant over the second pathway, which we experimentally confirmed by showing that mutations to pathway-I perturb nucleotide exchange more than mutations to pathway-II. In the future, insights into unique elements of each G protein family could inform the design of isoform-specific drugs. More broadly, our tools should also be useful for studying allostery in other proteins and assessing the extent to which this allostery is conserved in related proteins.