bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long forgotten perfume bottle nozzle in the uterus: challenges in retrieval in a low resource setting!
Authors: Chhetry Manisha , Yadav Jyotsna , Baniya Aashish 
Published: January 2025

Abstract
Foreign body in the uterus may lead to severe complications and pose significant management dilemmas. We report a 26-year-old lady who presented with foul-smelling discharge, subfertility, and a failed attempt at foreign body removal outside. Pelvic ultrasound revealed an impacted structure in the endocervical canal while a descending pipe was visualized in the endocervical canal per speculum examination. Partial removal vaginally and surgical removal of the nozzle via laparotomy was necessary due to the size, location, and impaction of the object. Posterior uterine incision was used due to easy accessibility. The post-operative stay was uneventful. This case underscores the importance of early detection, imaging, and multidisciplinary management in cases of uterine foreign bodies.
Osteopathic Manipulative Treatment for Postconcussive Symptoms: A Case Report
Authors: Tobon Steven , Bierbower Sonya , Giovanis Athina 
Published: January 2025

ABSTRACT
Concussions are a common form of mild traumatic brain injury characterized by a transient alteration of cerebral function leading to a range of physical, cognitive, and emotional symptoms. Postconcussive symptoms (PCSs) usually resolve in about a week but can persist in 10% to 15% of patients. If left untreated, PCS can profoundly affect a patient’s life. The authors present a case of a previously healthy patient who dealt with residual headaches and anxiety for 10 months after a head injury. She was treated with osteopathic manipulative treatment (OMT), which helped resolve her headaches and her anxiety. The OMT techniques applied during treatment included balanced ligamentous tension, myofascial release, and osteopathy in the cranial field techniques. OMT is a nonpharmacological, noninvasive treatment that can benefit patients suffering with PCS. The authors would like to increase the awareness of clinicians and researchers for OMT’s potential positive outcomes for PCS, as part of a multifactorial approach to care.
methylGrapher: genome-graph-based processing of DNA methylation data from whole genome bisulfite sequencing
Authors: Zhang Wenjin , Macias-Velasco Juan F , Zhuo Xiaoyu , Belter Edward A , Tomlinson Chad , Garza John , Tekkey Nina , Li Daofeng , Wang Ting 
Published: January 2025

Abstract
Genome graphs, including the recently released draft human pangenome graph, can represent the breadth of genetic diversity and thus transcend the limits of traditional linear reference genomes. However, there are no genome-graph-compatible tools for analyzing whole genome bisulfite sequencing (WGBS) data. To close this gap, we introduce methylGrapher, a tool tailored for accurate DNA methylation analysis by mapping WGBS data to a genome graph. Notably, methylGrapher can reconstruct methylation patterns along haplotype paths precisely and efficiently. To demonstrate the utility of methylGrapher, we analyzed the WGBS data derived from five individuals whose genomes were included in the first Human Pangenome draft as well as WGBS data from ENCODE (EN-TEx). Along with standard performance benchmarking, we show that methylGrapher fully recapitulates DNA methylation patterns defined by classic linear genome analysis approaches. Importantly, methylGrapher captures a substantial number of CpG sites that are missed by linear methods, and improves overall genome coverage while reducing alignment reference bias. Thus, methylGrapher is a first step toward unlocking the full potential of Human Pangenome graphs in genomic DNA methylation analysis.
Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
Authors: Wicher Grzegorz , Roy Ananya , Vaccaro Alessandra , Vemuri Kalyani , Ramachandran Mohanraj , Olofsson Tommie , Imbria Rebeca-Noemi , Belting Mattias , Nilsson Gunnar , Dimberg Anna , Forsberg-Nilsson Karin 
Published: January 2025

Abstract

Background
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, characterized by aggressive growth and a dismal prognosis. Interleukin-33 (IL-33) and its receptor ST2 have emerged as regulators of glioma growth, but their exact function in tumorigenesis has not been deciphered. Indeed, previous studies on IL-33 in cancer have yielded somewhat opposing results as to whether it is pro- or anti-tumorigenic.

Methods
IL-33 expression was assessed in a GBM tissue microarray and public databases. As in vivo models we used orthotopic xenografts of patient-derived GBM cells, and syngenic models with grafted mouse glioma cells.

Results
We analyzed the role of IL-33 and its receptor ST2 in nonmalignant cells of the glioma microenvironment and found that IL-33 levels are increased in cells surrounding the tumor. Protein complexes of IL-33 and ST2 are mainly found outside of the tumor core. The IL-33-producing cells consist primarily of oligodendrocytes. To determine the function of IL-33 in the tumor microenvironment, we used mice lacking the ST2 receptor. When glioma cells were grafted to ST2-deficient mouse brains, the resulting tumors exhibited a more invasive growth pattern, and are associated with poorer survival, compared to wild-type mice. Tumors in ST2-deficient hosts are more invasive, with increased expression of extracellular matrix remodeling enzymes and enhanced tumor angiogenesis. Furthermore, the absence of ST2 leads to a more immunosuppressive environment.

Conclusions
Our findings reveal that glia-derived IL-33 and its receptor ST2 participate in modulating tumor invasiveness, tumor vasculature, and immunosuppression in glioma.
The Arabidopsis basic–helix–loop–helix transcription factor LRL1 activates cell wall-related genes during root hair development
Authors: Haghir Shahrzad , Yamada Koh , Kato Mariko , Tsuge Tomohiko , Wada Takuji , Tominaga Rumi , Ohashi Yohei , Aoyama Takashi 
Published: January 2025

Abstract
Lotus japonicus-ROOT HAIR LESS1-LIKE-1 (LRL1) of Arabidopsis thaliana encodes a basic helix–loop–helix (bHLH) transcription factor (TF) involved in root hair development. Root hair development is regulated by an elaborate transcriptional network, in which GLABRA2 (GL2), a key negative regulator, directly represses bHLH TF genes, including LRL1 and ROOT HAIR DEFECTIVE6 (RHD6). Although RHD6 and its paralogous TFs have been shown to connect downstream to genes involved in cell morphological events, such as endomembrane and cell wall modification, the downstream network of LRL1 remains elusive. We found that a mutation of LRL1 causes a short-root hair phenotype and that this phenotype can be partially rescued by a transgene encoding a glucocorticoid receptor (GR) domain-fused LRL1, LRL1-GR, in the presence of glucocorticoids. Using this conditional rescue system, we identified 46 genes that are activated downstream of LRL1. Among these, the cell wall-related genes were significantly enriched and many of them were found to be immediately downstream of LRL1 without de novo protein synthesis in between. We further analyzed three representative genes, PROLINE-RICH PROTEIN1 (PRP1), PRP3, and XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDOLASE12 (XTH12). Reporter gene analyses showed that these genes are specifically transcribed in root hair cells including those in the root–hypocotyl junction, and that their proteins were localized to the cell wall of elongating root hairs, root hair bulges, and root hair bulge-expecting loci. A T-DNA insertion mutant of PRP3 showed a moderate short-root hair phenotype. Based on these results, LRL1 is likely to promote root hair development throughout the morphogenetic process by activating cell wall-related genes.
Quantifying behavior-based gender discrimination on collaborative platforms
Authors: Vásárhelyi Orsolya , Vedres Balázs 
Published: January 2025

Abstract
Digital collaborative platforms have become crucial venues of career advancement and individual success in many creative fields, from engineering to the arts. Gender discrimination related to behavioral choices of users is a key component to gendered disadvantage on platforms. Such platforms carried the promise of opening avenues of advancement to previously discriminated groups, such as women, as platforms lack managerial gatekeepers with conventional prejudice. We analyzed the extent of behavior-based gender discrimination on two digital platforms, GitHub and Behance, focused on software development and fine arts and design. We found that the main cause of women’s disadvantage in attention, success, and survival is largely due to the gender typicality of their behavior that varies between 60 and 90% of the total disadvantage of women. Men and women are penalized if they follow highly female-like behavior, while categorical gender is no longer significant. As platforms employ algorithmic tools and AI systems to manage users’ activity and visibility, and recommend new projects to collaborate, stereotypes associated with behavior can have long-lasting consequences.
AI for all: bridging data gaps in machine learning and health
Authors: Wang Monica L , Bertrand Kimberly A 
Published: January 2025

Abstract
Artificial intelligence (AI) and its subset, machine learning, have tremendous potential to transform health care, medicine, and population health through improved diagnoses, treatments, and patient care. However, the effectiveness of these technologies hinges on the quality and diversity of the data used to train them. Many datasets currently used in machine learning are inherently biased and lack diversity, leading to inaccurate predictions that may perpetuate existing health disparities. This commentary highlights the challenges of biased datasets, the impact on marginalized communities, and the critical need for strategies to address these disparities throughout the research continuum. To overcome these challenges, it is essential to adopt more inclusive data collection practices, engage collaboratively with community stakeholders, and leverage innovative approaches like federated learning. These steps can help mitigate bias and enhance the accuracy and fairness of AI-assisted or informed health care solutions. By addressing systemic biases embedded across research phases, we can build a better foundation for AI to enhance diagnostic and treatment capabilities and move society closer to the goal where improved health and health care can be a fundamental right for all, and not just for some.
Bonds without belonging? The genuine link in international, union, and nationality law
Authors: Spieker Luke Dimitrios , Weber Ferdinand 
Published: January 2025

Abstract
What kind of connection should form the basis of nationality? For decades, the ‘genuine link’ has been a central, yet controversial concept in international and European scholarship and practice. The controversy revolves around a simple question: does nationality require a certain degree of belonging? Or put differently, can there be such bonds without belonging? Recently, the debate has been rekindled by the Maltese practice of ‘golden passports’. This contribution traces the state of the debate, anchors the genuine link requirement in international and Union law, develops its contours and conditions, and discusses possible objections. We argue that the genuine link requirement is the result of an interplay of several sources: international law, the prohibition of abuse of law, and the constitutional principles of solidarity and democracy. Together, they form the basis for the genuine link in European Union law.
Peripheral neuropathy: from guidelines to clinical practise
Authors: Jordan Berit , Jahn Franziska , Jordan Karin 
Published: January 2025

Purpose of review
Chemotherapy-induced peripheral neuropathy (CIPN) is a substantial adverse effect of anticancer therapy. No effective preventive strategies are established in clinical routine, although some forms of cryotherapy or compression therapy seem to be promising. CIPN is difficult to grade objectively and has mostly relied on a clinician- or patient-based rating that is subjective and not easily reproducible.

Recent findings
Recent preclinical and clinical studies showed an indicative hint of serum neurofilaments for axonal damage as a biomarker and might be introduced in clinical practice in the future. Axonal degeneration in toxic neuropathy is triggered by molecular pathways including SARM1. Presence of certain genotypes predispose for developing severe vincristine neuropathy. Still, treatment of CIPN is focused on treating neuropathic pain primarily based on physicians experience. A positive effect of membrane stabilizers such as gabapentinoids could not be shown in a systematic review mostly due to inconsistent study populations. In the treatment and prevention of functional disability, physical exercise including sensorimotor-training and whole-body vibration seems promising.

Summary
More research is needed on quantification of biomarkers indicative for axonal degeneration prior to CIPN symptom expression. All these recent findings should support the health-care team for a patient centred treatment approach.
Immuno-oncology in the daily practice
Authors: Laparra Ariane 
Published: January 2025

Purpose of review
Immune checkpoint inhibitors (ICI) have become an integral part of oncology treatment. ICI currently has approval for more than thirty tumor types with proven efficacy. However, ICI can expose patients to inflammatory side effects, such as immuno-related adverse events (irAE). The spectrum of irAE and the time to onset can be very broad, sometimes leading to the patient's death.
Additionally, ICI could be associated with chronic or long-term adverse events that impact quality of life. The expansion of the indications for immunotherapy in the early adjuvant and neoadjuvant stages is altering the benefit-risk balance of these therapies.
Furthermore, the combination of immunotherapies with other oncology treatments makes the interpretation of adverse events difficult.
To date, no predictive factors have been identified in routine practice to identify patients at risk of developing serious toxicity.

Recent findings
This has led us to develop a patient care pathway dedicated to the management of these toxicities, enabling early detection of irAE to improve outcomes.

Summary
We have presented a novel care pathway based on a clinical evaluation, encompassing a daily hospital devoted to the management of toxicities, an iTox multidisciplinary board, and a pharmacovigilance database. This pathway involves a translational research program.
The toxicity day hospital allowed us to care for patients at an early stage of an adverse event and to establish whether anticancer treatment was responsible for the onset of symptoms and/or biological abnormalities.
The objective of this pathway is to enhance the quality of life and compliance of oncology treatment, while minimizing the necessity for unscheduled care.
The role of the microbiome in skin cancer development and treatment
Authors: Martin Fuentes Anthony 
Published: January 2025

Purpose of review
Recent research underscores the significant influence of the skin and gut microbiota on melanoma and nonmelanoma skin cancer (NMSC) development and treatment outcomes. This review aims to synthesize current findings on how microbiota modulates immune responses, particularly enhancing the efficacy of immunotherapies such as immune checkpoint inhibitors (ICIs).

Recent findings
The microbiota's impact on skin cancer is multifaceted, involving immune modulation, inflammation, and metabolic interactions. Beneficial strains like Bifidobacterium and Lactobacillus have shown potential in supporting anti-PD-1 and anti-CTLA-4 therapies by promoting T-cell activation and immune surveillance. Evidence from preclinical and clinical studies, including fecal microbiota transplantation (FMT), highlights improved response rates in patients with microbiota-rich profiles. Notably, certain bacterial metabolites, such as inosine, contribute to enhanced antitumor activity by stimulating IFN-γ in CD8+ T cells.

Summary
Understanding the interplay between microbiota and skin cancer treatment opens promising avenues for adjunctive therapies. Probiotic and prebiotic interventions, FMT, and microbiota modulation are emerging as complementary strategies to improve immunotherapy outcomes and address treatment resistance in melanoma and NMSC.
Robotic surgical techniques and methods for treating renal cell carcinoma with inferior vena cava tumor thrombus
Authors: Luo Jin , Li Zhuoran , Liu Qiwei , Jia Yuqi , Li Jinqiao , Zhao Houming , Chen Zhiqiang , Dong Yujie , Zhang Xu , Ma Xin , Huang Qingbo , Peng Cheng , Wang Baojun 
Published: January 2025

Abstract

Purpose of Review
Renal cell carcinoma with inferior vena cava (IVC) tumor thrombus (RCC-IVCTT) has a high mortality rate, and surgery is the only promising treatment. Open surgery has been the gold standard treatment for several decades. However, with the development of minimally invasive surgical technologies, the advantages of robotic surgery have gradually emerged. The classic Mayo Clinic Classification system has certain limitations in guiding robotic surgery. Therefore, a new classification system that is compatible with robotic surgery is urgently needed. Advancements in robotic surgery must be systematically summarized and evaluated.

Recent Findings
Since Abaza's initial report on robotic surgery, the exploration of robotic radical nephrectomy (RRN) with IVC thrombectomy has resulted in numerous related techniques and approaches, including surgical positions and approaches, control of blood vessels, assisted exposure, step-by-step strategy, and preoperative and intraoperative auxiliary technology and equipment. Our team proposed a new tumor thrombus classification system termed the “301 Classification” based on RRN with venous thrombectomy, which matches each level of tumor thrombus with a distinct robotic surgical strategy.

Summary
With advances in technology and accumulated experience, RRN with IVC thrombectomy holds promise as the preferred surgical option for RCC-IVCTT. Although “301 Classification” can provide objective advantages in robotic surgery, more cases are needed to be optimized for guiding surgery accurately. The overview provided in this paper aims to serve as a reference and inspiration for future research and clinical practice regarding RCC-IVCTT.
HELICOBACTER PYLORI ERADICATION TREATMENTS AND RISK OF ALZHEIMER DISEASE: A CASE–CONTROL STUDY NESTED IN THE FINNISH POPULATION
Authors: Keränen Emmi , Rysä Jaana , Tiihonen Miia , Hartikainen Sirpa , Tolppanen Anna-Maija 
Published: January 2025

Background:

Helicobacter pylori (H. pylori) has been inconsistently associated with risk of Alzheimer disease. The exposure assessment period has often overlapped with the prodromal time of Alzheimer disease. Cognitive disorders might increase vulnerability to infectious pathogens, complicating the ascertainment of temporal relationship between H. pylori infection and Alzheimer disease.

Methods:
This Finnish nested case–control study included 70,520 persons with incident Alzheimer disease diagnosed between 2005-2011 and 281,233 age-, sex-, and region of residence-matched controls. We obtained information on comorbidities and drug use from the national healthcare registers. We identified dispensed
H. pylori
eradication treatments from the Prescription register. We considered exposure at least 5 years before Alzheimer disease diagnosis in the main analysis. We compared risk of Alzheimer disease between
H. pylori
eradication treatment users and nonusers using confounder-adjusted (comorbidities and other drug use) conditional logistic regression. We assessed cumulative exposure by calculating the number of eradication treatments.

Results:
The prevalence of exposure to H. pylori eradication treatment at least 5 years before the outcome was 4.1% in cases and 3.9% in controls. The odds ratio (95% confidence interval) was 1.06 (1.02–1.11) in the crude and 1.03 (0.99–1.07) in the confounder-adjusted model. We observed no association between cumulative exposure and risk of Alzheimer disease.

Conclusion:
Our results, reflecting diagnosed and treated
H. pylori
infection late in life, do not support the hypothesis of
H. pylori
as an independent risk factor for Alzheimer disease. The previously reported association may be explained by reverse association and confounding.
Construction and demonstrative application of an evaluation indicator system for the distinction of ancient books of traditional chinese medicine based on the delphi method and analytic hierarchy process
Authors: Tong Lin , Zhang Weina , Zhang Lei , Li Meng , Liu Sihong , Chen Guangkun , Li Chen , Zhang Yu , Ye Junze , Su Zhaochen , Li Bing , Li Hongtao , Zhang Huamin 
Published: January 2025

Objective:
To construct a scientific and standardized evaluation indicator system for the distinction of ancient books of Traditional Chinese Medicine, aiming to provide a scientific basis for their cascade protection.

Methods:
The Delphi method was applied to establish the evaluation indicator system for the distinction of ancient books of Traditional Chinese Medicine, and the Analytic Hierarchy Process (AHP) was used to determine the weight of each indicator.

Results:
An evaluation indicator system for the distinction of ancient books of Traditional Chinese Medicine was developed, including 4 first-level indicators and 15 second-level indicators. The experts’ enthusiasm, authority, and coordination of opinions were all satisfactory.

Conclusion:
A evaluation indicator system for the distinction of ancient books of Traditional Chinese Medicine was preliminary constructed. The system is targeted, well-structured, and exhibits strong scientific and practical significance.
From the backroom to the boardroom: Health care chief information officers, stereotypes, and strategic leadership in the digital transformation era
Authors: Heath Michele L. , Silvera Geoffrey A. , Porter Tracy H. 
Published: January 2025

Issue
The digital transformation of the U.S. health care system is underway, but the role of health care chief information officers (HCIOs) in that transformation has been unclear. As the landscape of health care technology continues to expand, there is an increasing need to understand the influence of HCIOs, who are in a unique position to impact key strategic decisions. We seek to demonstrate the strategic importance of HCIOs in meeting the needs of digital transformation, by managing the emergence and strategic implementation of health care technologies to benefit health care organization performance. We also propose that profession-based stereotypes inhibit HCIOs as they may be viewed as behind-the-scenes technicians rather than strategic leaders.

Critical Theoretical Analysis
Upper echelons (UE) theory demonstrates how HCIOs' unique perspectives gained through education, experience, and the strategic decision-making process also can influence organizational performance. We build on UE to conceptualize the degree to which profession-based stereotypes moderate the decision-making of top management teams).

Theoretical Implications
We present two theoretical contributions. First, we introduce a profession-based stereotype moderated model of UE specific to HCIOs. Second, we offer an analysis of the role of HCIOs as strategic leaders in the digital transformation era.

Practice Implications
We call upon health care scholars and practitioners to examine HCIOs' influence and their roles in health care organization decision-making, top management team interactions, and organizational outcomes as the digital transformation in health care continues.