bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumors of the orbit and periorbital region: 20-year experience of the N.N. Blokhin National Medical Research Center of Oncology
Authors: Andreev T. R. , Kropotov M. A. , Azizyan R. I. , Mudunov A. M. , Dobrokhotova V. Z. 
Published: January 2025

Introduction. Neoplasms of the orbit and periorbital region are usually represented by tumors of the eyelid skin skin of the periorbital region and paranasal mucosa. The most common histological types of this pathology are squamous cell and basal cell carcinomas. The main indications for orbital exenteration are tumor lesions in the extraocular muscles and orbital apex and irreversible vision loss in the affected eye at the time of surgery planning. In the absence of these pathologies organ-sparing surgery is recommended. Resection of orbital and periorbital tumors (including orbital exenteration) leads to cosmetic and functional defects therefore surgical treatment of this area should be performed only if other methods are impossible or ineffective.Aim. To analyze the experience of resection of orbital and periorbital tumors and to evaluate short- and long-term results of surgical treatment of this pathology.Materials and methods. Retrospective analysis of patients with tumors of the orbit and periorbital region who underwent organ-sparing and exenteration surgeries between 2003 and 2023 was performed.Results. Overall 5-year survival was 55 %. It varied depending on a number of factors. The best 5-year survival rates were observed for basal cell carcinoma of the eyelid skin and periorbital region (83 %) the worst for squamous cell carcinoma (34 %) and melanoma (41 %). For localized tumors (Т1) overall survival was 76 % for locally advanced (Т4) – 43 %.Conclusion. Orbital and periorbital neoplasms are characterized by a variety of tumor morphological types and locations which requires multidisciplinary approach to treatment and rehabilitation of patients with this pathology.
Imperium Brytyjskie
Authors: Wiszniowska-Majchrzyk Marta , Miksza Agnieszka , Bednarek Zbigniew , Korporowicz Łukasz Jan , Kalinowska Anna , Zinkiewicz Grzegorz , Sosnowska Monika , Plesiewicz-Świerczyńska Izabela , Łukowska Maria , Deles Przemysław 
Published: January 2025

Chociaż po raz pierwszy określenie „imperium, nad którym nigdy nie zachodzi słońce” (the empire on which the sun never sets) zastosował Karol V Habsburg w odniesieniu do początków hiszpańskiej ekspansji kolonialnej, to odżyło ono w XIX wieku, gdy używano go głównie w kontekście brytyjskiego imperium – największego w nowożytnej historii świata. U szczytu swojej potęgi zajmowało ono około 36 milionów kilometrów kwadratowych, czyli mniej więcej jedną czwartą powierzchni naszej planety. Na jego obszarze, obejmującym ziemie leżące na wszystkich kontynentach, żył co piąty mieszkaniec naszego globu. […] Imperium odegrało zasadniczą rolę w ukształtowaniu współczesnego świata, formułując wstępne warunki do określenia zasad demokracji i współpracy międzynarodowej, a nawet zagadnień związanych z wielokulturowością.
Z artykułu Uwag kilka na temat brytyjskiego imperium wczoraj i dziś
prof. zw. dr hab. Krystyny Kujawińskiej Courtney
Uniwersytet Łódzki

Publikacja ma charakter naukowy, a interdyscyplinarność jest jej niezaprzeczalną zaletą. Łączenie w książce refleksji literaturoznawców, historyków i kulturoznawców dało w efekcie pracę złożoną, ciekawą, różnorodnie omawiającą badane zjawisko, a przez to atrakcyjną poznawczo dla czytelników reprezentujących odmienne zainteresowania, perspektywy oraz dziedziny akademickie.
Z recenzji prof. nadzw. dr hab. Aleksandry Budrewicz
Uniwersytet Pedagogiczny
im. Komisji Edukacji Narodowej w Krakowie
Detection and selection of dye-degrading bacteria from surface waters with different degrees of contamination
Authors: Grifes Paisan Luciana , Carballo Rodrigo Andrés , Papalia Mariana , Fortunato María Susana , Radice Marcela , Korol Sonia Edith , Gallego Alfredo 
Published: January 2025

ABSTRACT

Biodegradability and resistance from indigenous bacterial communities to dyes were tested using samples from both polluted and unpolluted surface waters in Buenos Aires. Five dyes were selected for the study: Acid Black 210, Direct Orange 39, Malachite Green, Gentian Violet, and Alizarin Red. Water quality was assessed by measuring chemical oxygen demand, biochemical oxygen demand, and both Escherichia coli and enterococci counts. Biodegradability was tested using a respirometric method, while resistance was assessed by determining the minimum inhibitory concentration (MIC). No bacterial strains capable of degrading the dyes as the sole carbon source were isolated from the respirometric tests. However, from the MIC tests, 28 strains capable of dye discolouration were identified, using nutrient broth as a supplement. Two of them were able to degrade Malachite Green and Acid Black 210 at a concentration of 50 mg L−1 in less than 24 h and with an efficiency greater than 87%. These strains were identified as Aeromonas sp. and Shewanella sp. through MALDI-TOF/MS and 16S rRNA gene sequencing. The determination of biodegradability and resistance can be used to enhance the characterization of watercourses. Furthermore, this methodology provides a means to isolate biodegrading bacteria that could be applied in effluent treatment processes.
Integrating MODFLOW and LSTM models for enhanced groundwater management in the coastal plains of Lattakia Governorate
Authors: Motawej Hadia 
Published: January 2025

ABSTRACT
Effective groundwater management is vital for ensuring the sustainability of water resources, particularly in regions with significant agricultural and residential demands. This study focuses on the coastal plain of Lattakia Governorate, a 140-km2 area southeast of Lattakia city, bounded by the Mediterranean Sea, the Al-Kabir Al-Shamali River, and the Al-Sanobar River. The objective was to evaluate the performance of the MODFLOW model, within the Groundwater Modeling System (GMS), for simulating groundwater levels and to assess the predictive capabilities of Long Short-Term Memory (LSTM) networks for forecasting temporal changes in groundwater levels. The methodology involved data collection from thirty observation wells, preprocessing for model calibration, and the integration of MODFLOW and LSTM outputs to create a hybrid framework. Findings indicate that MODFLOW effectively simulates physical groundwater processes, while LSTM captures nonlinear and temporal dynamics. The integration of these models reduced prediction errors by up to 20% compared to standalone approaches, enhancing prediction accuracy and reliability. This study provides a novel approach to groundwater management, offering actionable insights for sustainable agricultural practices, residential water security, and pollution mitigation. The proposed framework demonstrates scalability and adaptability to similar hydrological settings globally, contributing to the advancement of integrated groundwater management strategies.
Recent Progress in Curcumin: Extraction, Purification, and Bioactivity
Authors: Cao Hong-Mei , Zhao Pei-Hong , Zhao Yi-Tao , Fang Jiao-Jiao , Wang Ya-Nan , Chen Xin 
Published: January 2025

Abstract:
Curcumin is a natural plant pigment that has been widely used in food production,
drug development, and textile engineering. Gaining a deep understanding of the biological
activities of curcumin and obtaining high-purity curcumin are of vital importance
for basic research and applications of curcumin. In this review, we summarize recent advances
in curcumin, mainly focusing on the methods of extracting and purifying curcumin
from turmeric as well as applications based on biological activity. We systematically
describe the advantages and disadvantages of traditional and modern extraction technologies.
The usual purification methods include conventional methods (such as macroporous
resin column chromatography and silica gel column chromatography, etc.) and
auxiliary modern technologies (such as high-speed countercurrent chromatography and
supercritical fluid chromatography). In terms of biological activity, the phenolic hydroxy
group and methoxy group of curcumin are closely related to its antioxidant activity,
endowing it with strong antibacterial, anti-inflammatory, and antitumor properties.
Moreover, the development direction based on its multiple biological activities is also
discussed.
Investigation of the Antibacterial Activity and Antiproliferative Properties of Ag Nanoparticles Synthesized Using Lavandula angustifolia Sevtopolis Extract against Prostate Cancer Cell Lines
Authors: Mert Sivri Firdevs , Akkoc Senem , Onem Ebru , Allaberdyyeva Maysa , Saribas Rafet 
Published: January 2025

Introduction:
In this study, silver nanoparticles (AgNPs) were synthesized using Lavandula
angustifolia Sevtopolis (LA Sevtapolis) plant extract without using any reducing or stabilizing
agent.

Methods:
The morphologies, optical properties, and crystallinities of the prepared AgNPs were determined
using scanning electron microscopy, UV-visible spectroscopy, and X-ray diffraction.

Results:
The antibacterial activities of the synthesized AgNPs against some gram-negative and
gram-positive bacterial species were investigated. The lowest effect was observed against the
Gram-positive B. cereus ATCC 11778 with a concentration of 0.0375 μg/mL. Additionally, the toxic
effect on the human normal cell line HEK-293T and the antiproliferative activity against the
prostate (PC3) cancer cell line were examined. The IC50 values of AgNPs against PC3 and HEK-
293T cells were found to be 4.72 μL/mL and 6.838 μL/mL, respectively.

Conclusion:
In conclusion, due to their antiproliferative and antibacterial activities, AgNPs synthesized
using LA Sevtopolis extract were found to have potential applications in various biomedical
fields.
Trigger factors of general body overheating (scientific review)
Authors: Kravets O.V. , Yekhalov V.V. , Sedinkin V.A. , Myronov D.V. , Martynenko D.A. 
Published: January 2025

Global statistics show that approximately 489,000 people died annually from heat-related causes over the past two decades. Higher temperatures are associated with increased risk of mortality due to general accidents and four main subtypes, including road traffic accidents, falls, drownings, and unintentional injuries. Elevated temperatures and periods of anomalously hot weather already increase the global health hazard and cause significant economic losses. Mortality from general overheating is high and ranges from 33 to 80 %, with terminal events including shock, arrhythmias, myocardial infarction, renal failure, and neurological dysfunction. Residual neurological disorders were observed in 17 % of survivors. General overheating affects military personnel, athletes, workers in hot industries, and civilian populations exposed to or having formed risk factors for general inadvertent body overheating. Therefore, identifying and, where possible, preventing these risk factors is currently relevant. Exogenous hyperthermia contributing and predisposing factors are identified, timely detection and prevention of which will allow medical and social workers to limit the detrimental effects of hot conditions on public health.
ESTIMULACIÓN TEMPRANA Y DESARROLLO INFANTIL
Authors: Niño Parada Christian Daniel , Pacheco Gómez Ilianis Katiuska , Romero Medrano Jenny Margarita 
Published: January 2025

Introducción. La estimulación temprana (ET) es crucial para el desarrollo de niños de 0 a 5 años, sin embargo, en el barrio Nelson Pérez de Ciénaga, Magdalena, se enfrentan a desafíos que limitan su acceso a una Estimulación Temprana adecuada, estos desafíos incluyen la falta de conocimiento de los padres y cuidadores sobre la importancia de la ET, limitaciones económicas, y la influencia de la pandemia que aumentó el uso de dispositivos electrónicos como reemplazo de la ET. Además, muchos niños son hijos de padres adolescentes con poca escolaridad y viven en hogares con recursos limitados, situación que tiene un impacto significativo en el desarrollo infantil y requiere un análisis exhaustivo para comprender sus causas y consecuencias a largo plazo. Objetivo. Comprender las razones de la falta de estimulación temprana por parte de padres de familia y/o cuidadores en niños y niñas de 1 a 5 años, del barrio Nelson Pérez de Ciénaga (Magdalena). Metodología. La metodología del estudio se basó en un enfoque cualitativo de investigación utilizando entrevistas, observación y análisis de contenido para comprender las razones detrás de la falta de estimulación temprana en niños de 0 a 5 años en el barrio Nelson Pérez de Ciénaga, Magdalena. Se trabajó con una muestra no probabilística de 10 padres/madres o cuidadores y dos agentes educativas de la Unidad de Atención "Niños y Niñas del Nuevo Futuro". Se realizaron entrevistas semiestructuradas y se analizaron los datos cualitativamente para identificar las causas de la falta de estimulación temprana en la comunidad. Resultados. se sensibilizó los beneficios acerca de la importancia de implementar en el proceso de crianza la estimulación temprana en niños y niñas. Conclusiones. Se resalta la necesidad de promover la estimulación temprana y la formación familiar, destacando la importancia de la colaboración interinstitucional para abordar este desafío y fomentar el desarrollo óptimo de los niños y niñas desde sus primeros años de vida.
Analysis of the Effect of Wastewater Quality on the Effectiveness of Eco-Enzyme
Authors: Viareco Hariestya , Yanova Shally , Jalius Jalius , Naswir Muhammad , Dewi Nabila Sastra , Mutmainnah Elma , Ziadah Besse Syaharani , Khatamsi Muhammad , Putri Prameswari Amalia , Zahra Kintan Larasati , Wahyuni Dini Sri , Meduripa Harry Fajra , Iskandar Jumary 
Published: January 2025

Eco-enzyme represents a biological solution derived from the fermentation of organic materials, evaluated for its effectiveness in industrial wastewater treatment. This study examines to investigate the effectiveness of eco-enzymes in improving the quality of industrial wastewater by analyzing their impact on four specific types of liquid waste: landfill leachate, tofu wastewater, batik wastewater, and laundry wastewater. Samples were treated with eco-enzyme at specific concentrations and incubated for 5 days, followed by chemical analysis. Eco-enzyme reduced ammonia levels in landfill leachate by 57% to 8.83 mg/L, though COD and BOD values rose to 18,114.6 mg/L and 46,709 mg/L, respectively, exceeding effluent standards. In tofu wastewater, COD and BOD decreased by 72% and 75% to 4,189.68 mg/L and 2,395.3 mg/L, respectively, but remained above regulatory limits. Batik wastewater showed increases in most parameters, with COD and BOD reaching 6,838.85 mg/L and 3,193.5 mg/L. For laundry wastewater, surfactants decreased by 55% to 12.97 mg/L, but BOD and TSS increased. These findings indicate that while eco-enzyme can reduce specific pollutants like ammonia and surfactants, its application can also elevate COD and BOD levels in some cases. Additional treatment processes, such as aeration or coagulation, are required to achieve effluent standards. Despite its limitations, eco-enzyme holds potential as an environmentally friendly option for industrial wastewater management when integrated with complementary technologies.
Treatment of nonunion cases with linear external fixation in cats: 10 cases (2022–2023)
Authors: Gülaydin Ali 
Published: January 2025

Abstract

Objective
This study aimed to evaluate the clinical and radiologic findings in the treatment of live oligotrophic and pseudoarthrosis nonunions in cats using a linear external fixator.

Methods
The study included 10 cats of various breeds, ages, and sexes that had previously undergone osteosynthesis at another clinic but did not achieve successful results. These cats were diagnosed with nonunion based on clinical and radiographic examinations conducted at the Clinic of the Surgery Department, Siirt University Animal Health Practice and Research Hospital between 2022 and 2023. All included cats presented with clinical and radiographic signs of nonunion fractures. The fractures were categorized as oligotrophic or pseudoarthrosis types of nonunion, requiring further surgical intervention.

Results
All 10 cats recovered successfully without severe complications. Bone healing was completed within an average of 57.8 days, ranging from 47 to 71 days.

Conclusions
This study highlights the effectiveness of linear external fixation in treating nonunion fractures in cats. The method demonstrated a high success rate, with all cases recovering fully.

Clinical Relevance
Tailoring the treatment to the animal's size, fracture location, and nonunion classification makes this approach a valuable clinical tool for veterinarians managing such cases.
Modulatory role of quercetin against chlorpyrifos induced blood toxicity in rats
Authors: Kaur Simranjeet , Shukla Ananya , Singla Neha , Dhawan D. K. 
Published: January 2025

Abstract
Chlorpyrifos (CPF) is a broad-spectrum organophosphate insecticide and has been reported to cause a number of serious deleterious effects on physiological systems. The present study was designed to evaluate the role of quercetin (QC) during CPF induced toxicity in blood cells. Female Wistar rats weighing 150–200 g were divided into four different groups viz: Normal Control, CPF treated (13.5 mg/kg body weight every alternate day), QC treated (50 mg/kg body weight/day) and combined CPF + QC treated. The effects of different treatments were studied on various hematological parameters as well as on anti-oxidant defense system. CPF treated animals showed a significant decrease in total leukocyte counts (TLC), lymphocyte counts, hemoglobin (Hb) levels and aminolevulinic acid dehydratase (ALAD) activity, which however showed appreciable improvement upon simultaneous treatment with QC. Contrarily, neutrophils counts were found to be significantly increased, which, however, were decreased upon simultaneous treatment with QC. Further, CPF exposure caused a significant increase in the levels of lipid peroxidation (LPO) and protein carbonyl content (PCC) as well as increased the activities of super oxide dismutase (SOD) and catalase (CAT) in blood, which were decreased on QC co-treatment. Moreover, CPF treatment also caused inhibition of glutathione system in blood but QC co-treatment was able to up-regulate the glutathione system. Therefore, the present study, suggests that QC unveils a protective potential in containing CPF induced blood toxicity.
Peningkatan Pengetahuan Tentang Nutrisi Pada Remaja di Santi Witya Serong School
Authors: Ulfah Erliana , Hidayat Reni , Anggraeni Erni , Nursari Linda Astrea , Mulya Ika Wartika , Rohita Tita 
Published: January 2025

Masalah gizi pada anak terkadang dapat berlanjut menjadi masalah gizi pada remaja, seperti kekurangan zat besi (anemia) atau kelebihan berat badan (obesitas). Thailand berada pada jalur yang tepat untuk memenuhi satu target gizi ibu, bayi dan anak kecil (MIYCN). Belum ada kemajuan yang dicapai dalam mencapai target pengurangan anemia di kalangan perempuan usia subur, dimana 24,0% perempuan berusia 15 hingga 49 tahun kini terkena dampaknya. Indikator yang menentukan status Gizi anak dapat pula dilihat dari capaian stunting yang merupakan masalah gizi kronis yang disebabkan oleh kurangnya asupan gizi dalam waktu lama. Tujuan dari pengabdian masyarakat ini adalah untuk menambah pengetahuan remaja dalam meningkatkan kemandirian dalam asupan nutrisi pada remaja. Pengabdian dilakukan dengan memberikan penyuluhan mengenai nutrisi pada remaja. Hasil pengabdian menunjukkan bahwa kegiatan penyuluhan ini dapat meningkatkan pengetahuan siswa tentang nutrisi pada remaja di Santi Witya Serong School. Saran untuk pihak sekolah yaitu mengadakan pemeriksaan kesehatan berupa pengukuran antropometri, pemeriksaan kadar HB dan pemeriksaan SADARI.
Optimalisasi Pelayanan Asuhan Keperawatan Melalui Pelatihan Ronde Keperawatan di RSUD Ciamis
Authors: Rohita Tita , Permana Dedeng Nurkholik Sidik 
Published: January 2025

Rumah Sakit mempunyai kewajiban untuk memberikan pelayanan secara menyeluruh dan selalu berupaya semaksimal mungkin untuk meningkatkan kepuasan pasien. Dalam situasi seperti ini,patient centered care merupakan salah satu proses keperawatan yang merupakan suatu strategi keperawatan yang sangat efektif khususnya dalam meningkatkan komunikasi antar staf keperawatan mengenai interaksi antar perawat. Tujuan dari pengabdian masyarakat ini adalah untuk mengoptimalkan pelayanan perawatan terhadap pasien. Layanan tersebut akan diberikan kepada perawat di bangsal Hassan Sobari di RSUD Siamis. Metode pelayanan dilakukan dalam tiga tahap. Diskusi kelompok terfokus dengan perawat untuk mengidentifikasi permasalahan, hasil FGD menunjukkan bahwa ronde keperawatan belum dilakukan secara maksimal, melakukan pre dan post test, serta memberikan dokumentasi. Pada fase Nursing Round ke 3 terkait implementasi, kami akan melakukan role play untuk melaksanakan Nursing Round di dalam ruangan. Materi yang akan dikirimkan antara lain brosur dan informasi. Hasil setelah menyelesaikan pengabdian masyarakat menunjukkan bahwa pengetahuan perawat dalam menyelesaikan putaran meningkat, mayoritas menyatakan “kurang baik” dan mayoritas menyatakan “baik”. Setelah melaksanakan ronde keperawatan, kepuasan pasien meningkat hingga 90%. Putaran keperawatan harus dilakukan secara teratur untuk menyelesaikan masalah perawatan pasien. Hal ini memerlukan keterlibatan pasien, diskusi, dan implementasi perawatan.
Методы и проекты ренатурализации малых рек в городской среде: международный опыт
Authors: Старцева Е.А. 
Published: January 2025

Изучены методы и этапы ренатурализации малых рек с использованием международного опыта в городских условиях. Акцент сделан на структурировании этапов ренатурализации на основе современного мирового опыта. Первый этап исследования включает анализ существующих методов ренатурализации малых рек, представленных в зарубежных и отечественных исследованиях. Представлены этапы практической реализации проектов ренатурализации малых рек в городах. Исследование позволяет выявить оптимальные подходы к реабилитации малых рек в городских условиях, учитывая не только технические, но и социально-экологические аспекты.
This article is devoted to the study of methods and stages of re-naturalization of small rivers using international experience in urban conditions. The emphasis is on structuring the stages of re-naturalization based on modern world experience. The first stage of the study includes an analysis of existing methods of re-naturalization of small rivers presented in foreign and domestic studies. The stages of practical implementation of projects for the re-naturalization of small rivers in cities are presented. The study makes it possible to identify optimal approaches to the rehabilitation of small rivers in urban conditions, taking into account not only technical aspects, but also socio-ecological aspects.