bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a Cognitive Behavioural Therapy (CBT)-based intervention for reducing anxiety among adolescents in the Colombo District, Sri Lanka: Cluster randomized controlled trial
Authors: De Silva Sinha , Peris Renuka , Senaviratne Sudharshi , Samaranayaka Dulani 
Published: January 2024

Abstract

Anxiety disorders are found to be the most prevalent psychological problems among children and adolescents. Cognitive behaviour therapy (CBT) was found to be effective at reducing anxiety. The purpose of this study was to assess the effectiveness of a universal school-based intervention for reducing anxiety among Grade 9 schoolchildren. A randomized controlled cluster trial was conducted by randomly assigning 36 schools in the Colombo district in Sri Lanka into study and control arms, each comprising 18 schools with 360 students. The levels of anxiety, self-esteem and depression status were assessed using the validated Screen for Child Anxiety Related Disorders (SCARED) tool and the Rosenberg self-esteem scale, respectively, and the Depression, Anxiety and Stress Scale 21 (DASS-21) at baseline, after intervention, and after 3 months. A CBT-based universal intervention package was administered weekly by a trained teacher for eight weeks with a one-month self-practice period to a randomly selected Grade 9 class in each school in the study arm. The control arm received routine care. Anxiety and self-esteem scores and depression status were compared between the two arms after the intervention and at 3 months of follow-up using the generalized estimation equation (GEE), controlling for confounding and clustering. The nonresponse and loss to follow-up rates were < 1%. When comparing the study arm with the control arm using GEE, anxiety levels were significantly lower (β = 0.024, 95% CI = 0.055 − 0.006, p = 0.115) but not postintervention (β = 0.024, 95% CI = 0.055 − 0.006, p = 0.115). There were no significant differences in depression status after intervention (OR = 0.256, 95% CI 0.052–1.286; p = 0.098) or follow-up (OR = 0.42, 95% CI 0.117–1.008; p = 0.052), and self-esteem significantly increased after intervention (β = 0.453, 95% CI = 0.264–1.145; p = 0.2321) but not at follow-up. This study revealed that the universal package based on CBT is effective at reducing anxiety and improving self-esteem among adolescents. The trial registration number and date were SLCTR/2018/018 and 19th of June 2018 respectively.
Evaluation of left ventricular blood flow kinetic energy in patients with acute myocardial infarction by 4D flow MRI: a preliminary study
Authors: Niu Xiqing , Dun Yutong , Li Guoce , Zhang Houning , Zhang Bin , Pan Zhibin , Bian Hao , Kang Liqing , Liu Fenghai 
Published: January 2024

Abstract
Purpose: To evaluate the intracavity left ventricular (LV) blood flow kinetic energy (KE) parameters using four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) in patients with acute myocardial infarction (AMI).
Methods: Thirty AMI patients and twenty controls were examined via CMR, which included cine imaging, late gadolinium enhancement (LGE) and global heart 4D flow imaging. The KE parameters were correlated with the left ventricular end-diastolic volume (LVEDV) to obtain average, minimal, systolic, and diastolic KE as well as the proportion of LV in-plane KE (%). These parameters were compared between the AMI patients and controls and between the two subgroups.
Results: Analysis of the LV blood flow KE parameters at different levels of the LV cavity and in different segments of the same level showed that the basal level had the highest blood flow KE while the apical level had the lowest in the control group. There were significant differences in diastolic, systolic and diastolic in-plane KE between the anterior wall and posterior wall (p>0.05). Compared with those in the control group, the average (10.7±3.3 μJ/mL vs. 14.7±3.6 μJ/mL, p<0.001), systolic (14.6±5.1 μJ/mL vs. 18.9±3.9 μJ/mL, p=0.003) and diastolic KE (7.9±2.5 μJ/mLvs. 10.6±3.8 μJ/mL, p=0.018) were significantly lower in the AMI group. The average KE in the infarct segment was lower than that in the noninfarct segment in the AMI group, while the proportion of systolic in-plane KE increased significantly (49.5±18.7 μJ/mL vs. 126.3±50.7 μJ/mL, p<0.001; 61.8%±11.5 vs. 42.9%±14.4, p=0.001).
Conclusion: The 4D flow MRI technique can be used to quantitatively evaluate LV regional haemodynamic parameters. There were differences in the KE parameters of LV blood flow at different levels and in different segments of the same level in healthy people. In AMI patients, the average KE of the infarct segment decreased, while the proportion of systolic in-plane KE significantly increased.
Impact of Preoperative Inflammatory Indices and Postoperative Pneumonia on Postoperative Atrial Fibrillation in Patients with Non-Small Cell Lung Cancer: A Retrospective Study
Authors: Ruan Yingding , Han Jianwei , Yang Aiming , Ding Qingguo , Zhang Ting 
Published: January 2024

Abstract

Background: This study aimed to evaluate the impact of preoperative inflammatory indices and postoperative pneumonia (POP) on postoperative atrial fibrillation (POAF) in non–small cell lung cancer (NSCLC) patients.
Methods: All consecutive patients who underwent pulmonary resection at our hospital (January 2016-October 2019) were enrolled. Preoperative inflammatory indices, demographic data, surgical details, and postoperative conditions were analyzed. Univariate and multivariate analyses of risk factors associated with POAF were also conducted.
Results: Among the 382 patients included in the study, 32 (8.38%) developed POAF. Approximately 31 patients (96.9%) developed atrial fibrillation within three days after surgery. The POAF group had a significantly greater mean age (68 years) than did the non-POAF group (62 years) (P=0.002). Additionally, compared with non-POAF patients, POAF patients exhibited an increased number of mediastinal lymph nodes (P<0.001) and mediastinal lymph node stations (P<0.001). The POAF group also had a greater intraoperative blood volume (P=0.006), longer surgical duration (P=0.022), greater incidence of POP (P=0.09), and greater drainage volume (P=0.003). TNM stage (P<0.001) and type of lung resection (P=0.049) were also associated with POAF. Compared to those in the non-POAF group, the POAF group had longer postoperative hospital stays (10.54 days vs. 9 days; P=0.001) and longer drainage times (7 days vs. 5 days; P=0.004). Multivariate analysis revealed age, POP grade, and TNM stage as independent predictors of POAF in NSCLC patients.
Conclusion: Preoperative inflammatory indices were not significantly associated with POAF, but age, POP, and TNM stage were identified as independent predictors. Early-stage NSCLC patients may have a greater susceptibility to POAF than early-stage patients, although further validation is needed. Additionally, POAF was linked to a longer postoperative hospital stay.
Technophilia or technophobia: The unified model of the paradox of older adults’ digital learning
Authors: Wang Ya-Ling 
Published: January 2024

Abstract
Background: Previous research investigating technology adoption has emerged prominently; however, little has been done with older adults’ approach-avoidance conflict toward digital learning. To fulfill the need of accumulating older adult learners, the current research comprehensively incorporates all target-specific elements related to the process of digital learning for older adults. Particularly, the unified model highlights barrier factors and offers insights into the nature of their paradoxical hesitation towards technology.
Methods: In this study, a total of 20 older adults (mean age 63.85 and 25% male) were interviewed. Interviews were recorded for thorough analysis. The coding framework guided data analysis to achieve research objectives.
Results: The findings revealed that: (1) social influence was found as older adults’ major precursor of exposure to digital technology; (2) both acceptance and barrier factors emerged regarding older adults’ digital learning; (3) older adults feature paradoxical hesitation towards technology; (4) three types of senior digital learners were identified: tech-native learners; tech-novice learners; tech-rejector learners.
Conclusions: The unified model of the paradox of older adults’ digital learning was created, highlighting barrier factors and offers insights into the nature of their paradoxical hesitation towards technology. This study contributes a reference for elderly digital learning field and serving the accumulated number of older adult learners.
Impact of the COVID-19 Pandemic on Children’s Mental Health in Taiwan: 2021–2022 Two-Year Follow-up Study
Authors: Chien Wei-Hsien , Chang Hsin-Fang , Shia Ben-Chang , Wang Kai-Hsun , Shih Yi-Nuo , Tai Yi-Hsien , Chen Ming-chih 
Published: January 2024

Abstract
Background
According to the most comprehensive mental health report in the past two decades by the World Health Organization, nearly one billion people experienced mental health issues prior to the coronavirus disease 2019 (COVID-19) pandemic. Following its outbreak in 2021, the rates of depression and anxiety increased by 25%, which highlights its impact on mental health at the global scale. This study aims to elucidate the impact of the COVID-19 pandemic on children’s mental health and to raise awareness among various stakeholders, including educators and governments.
Methods
To analyze and evaluate the indicators of mental health in children, we used a structured questionnaire that was previously designed with good reliability and validity. We focused on assessing six major categories related to children’s mental health in 2021 and 2022. We collected 1,000 valid responses from parents and their children for in-depth analysis (men: 538; women: 462).
Results
The average total indices of children’s mental health were 66.50 and 63.83 in 2021 and 2022, respectively. The results of the six indices for both years were as follows: “Personal Life”: 68 and 66; “Family Life”: 70 and 70; “Peer Relationship”: 77 and 73; “School Life”: 68 and 68; “Online Social Interaction”: 60 and 55; and “Epidemic Life”: 56 and 51, respectively. During the COVID-19 pandemic, the top three activities of children aside from attending online classes were watching TV (66.0%), browsing the Internet (62.0%), and playing video games (50.7%).
Conclusions
Children reported challenges with online exposure and academic pressure. The COVID-19 pandemic significantly affected their mental health, which impacted learning, socializing, and family dynamics. Specifically, family dynamics and environment emerged as significant influencing factors on the overall well-being of the children during these times. Consequently, collaborative effort among schools, communities, and governments is essential for improving or maintaining the mental health of children.
Trial registration: C110199
Identification of key biomarkers associated with oral squamous cell carcinoma prognosis and immune response
Authors: Wang Yetong , Zhu Xuan , Wu Dan , Zhou Rong , Tan Jin , Zhu Zibing , Zhu Keke 
Published: January 2024

Abstract
Introduction
Oral squamous cell carcinoma (OSCC) ranks as the sixth most prevalent malignancy globally, presenting a significant threat to both physical and mental health due to its elevated incidence and metastasis rate. Advancements in understanding and treating OSCC have stagnated over the past three decades. Oral submucous fibrosis (OSF), a chronic inflammatory oral condition, manifests with pale lesions and limited mouth opening. Notably, the onset of OSCC is often observed against the backdrop of OSF, particularly linked to areca nut consumption. The molecular mechanisms underlying this association, however, remain elusive. This study aims to elucidate the shared genetic markers between OSF and OSCC, intending to enhance early tumor diagnosis.
Methods
We retrieved GEO, DAVID, STRING, GEPIA, UALCAN database and visualized them using tools such as GEO2R, Cytoscape, and R packages. We conducted a comprehensive bioinformatics analysis to investigate the associations between prognosis-related hub genes, their prognostic roles, and immune cell infiltration.
Results
161 DEGs were retrieved and a PPI network was constructed and imported into Cytoscape for visualization. We identified nine critical genes: CDK1, DLGAP5, KIF20A, HMMR, NDC80, CDCA3, CENPE, CCNB2, CKAP2. Notably, two of these hub genes, CDK1 and HMMR displayed significantly elevated expression in both OSCC and OSF samples.
Conclusion
In conclusion, nine hub genes were screened out as potential oncogenes of OSCC patients that could help us early detection, early diagnosis, early prevention. CDK1 and HMMR were key biomarkers associated with oral squamous cell carcinoma prognosis and immune response.
Genetic Profiling and Taxonomic Authentication of Indian Phyllanthus (Phyllanthaceae: Phyllantheae) Genus through Molecular Phylogeny, DNA Barcoding, and ITS2 Secondary Structure Predictions: A Comprehensive Analysis
Authors: Raghavendra P , Ganesh Pushpalatha , Chalageri Gururaj , Kannan R , V Babu U 
Published: January 2024

Abstract

Phyllanthus is a genus of plants that are both ecologically and medicinally valuable. This diversity highlights the need for accurate identification in order to support both conservation efforts and medical research. The escalating demand for Phyllanthus-derived herbal products raises concerns regarding market adulteration and misidentification. In response, our study employs DNA barcoding, specifically targeting the internal transcribed spacer 2 (ITS2) region, to authenticate Indian Phyllanthus species. The study underscores the ITS2 region's efficacy in identifying Indian Phyllanthus species, demonstrating substantial advancements in resolving genus relationships compared to prior analyses. To check if our plant DNA matches known ones, we used two tools: NCBI BLASTn and the ITS2 database. The results showed really high similarities, ranging from 98–100%. This helps us understand how closely related our plant is to others in the Phyllanthus family. We deposited the genetic data, particularly DNA sequences, of Phyllanthus plants into the NCBI GenBank repository. The construction of a phylogenetic tree through multiple sequence alignment of the ITS2 gene confirms clustering among Phyllanthus species, illuminating genetic relationships and diversity crucial for conservation. The ribosomal nuclear ITS2 region exhibits notable differences within and between species, validated by DNA barcodes and secondary structure analyses using minimum free energy calculations. This study underscores the effectiveness of ITS2-based DNA barcoding in accurately identifying Phyllanthus species, mitigating adulteration concerns, ensuring product quality, preserving biodiversity, and promoting sustainable utilization of these invaluable plant resources.
The impact of Resveratrol on the outcome of the in vitro fertilization: a pilot randomized controlled trial
Authors: Conforti Alessandro , Iorio Giuseppe Gabriele , Girolamo Raffaella Di , Rovetto Marika Ylenia , Picarelli Silvia , Cariati Federica , Gentile Rosaria , D'Amato Antonio , Gliozheni Orion , Fioretti Bernard , Alviggi Carlo 
Published: January 2024

Abstract
Background
Resveratrol is a natural polyphenolic compound present in plants and red wine with many potential health benefits. This compound has various anti-inflammatory and anti-tumor properties and can improve cellular mitochondrial activity. This pilot trial was designed to evaluate the effect on the outcome of IVF of Resveratrol supplementation in women > 35 years with good ovarian reserve (AMH > 1.2 ng/ml). Women were randomized to receive or placebo or Resveratrol (150 mg twice per day) for three months preceding the ovarian stimulation (OS). All patients were stimulated with a starting dose of recombinant FSH ranging between 150 and 300 IU according to age and ovarian reserve. GnRH antagonist flexible protocol was adopted for pituitary suppression. Triggering was performed with urinary hCG (10.000 IU).
Results
The study was conducted between January 2019 and December 2022 with aa total of 37 cases and 33 controls were recruited. A statistically significant increase in the follicle output rate (FORT) and follicle-to oocyte index (FOI) in women treated with resveratrol was observed compared with control group (0.92 versus 0.77 [p = 0.02], and 0.77 versus 0.64 [p = 0.006], respectively). No statistically significant differences in the number of oocytes retrieved, biochemical pregnancy, clinical pregnancy and live birth rates were observed between groups.
Conclusions
Preliminary results from this study indicate that pre-treatment with resveratrol may improve ovarian sensitivity to exogenous FSH, which in turn may decrease the risk of hypo-response to OS.
Management of Bladder Injury During Caesarean Delivery and Long-Term Results
Authors: Tunçekin Adem , Yalçın Mehmet Yiğit 
Published: January 2024

Abstract
Purpose: The urinary bladder injury after cesarean delivery is rare but significant. This study aims to evaluate the management of bladder injuries after cesarean section and long-term postoperative results.
Methods: Our study included 67 patients who had bladder injuries after cesarean section and underwent repair. Patients with non-bladder genitourinary organ injuries and/or injuries other than those associated with cesarean delivery were excluded. The patients’ demographic records and pre- and postoperative data were evaluated retrospectively.
Results: Between September 2018 and February 2023, 123,296 pregnant women were admitted to our hospital for birth; 46,786 (38%) cesarean deliveries occurred, and 67 patients suffered bladder injuries (0.14%). Diagnosis was made intraoperatively in 58 patients and postoperatively in 9 patients. The average age of the patients was 33,8 years and the average number of cesarean sections the patients had undergone was 3,2. The average bladder defect size was 4,4 cm, and they were most frequently observed in the bladder dome. When evaluated in the early period (first month postpartum) and late period (after the first month), lower urinary tract symptoms were observed in a total of 16 patients, and the most common symptom was dysuria.
Conclusions: Bladder injury during cesarean delivery is a rare but serious condition. When bladder injury is suspected, diagnosis and treatment should be done promptly to minimize complications. Our study draws attention to this topic, and prospective studies with larger populations and longer follow-up periods are needed to obtain more conclusive results.
Use of a Needle Probe to Measure the Thermal Conductivity of Electrically Conductive Liquids at High Temperatures
Authors: Ruth Ryan , Merritt Brian , Munro Troy 
Published: January 2024

Abstract
This paper considers the necessary conditions for using a derivative of a transient hot wire (termed a needle probe) approach to measure electrically conducting fluids at high temperatures, especially molten halide salts. The focus is on the development of a new theory based on a multi-layer system necessary to ensure electrical isolation of electrical wires from the surrounding fluid. This includes the use of a thin annulus of fluid to minimize convective heat transfer modes within the fluid of interest, which was inspired by the concentric cylinder method. Good measurements require the following considerations: concentricity of the probe and surrounding crucible to ensure a consistent fluid gap, accounting for corrections for deviation of the model at early times, and modeling radiation heat transfer through transparent fluids. Uncertainties are larger than transient hot wire methods because of the deviations from experimental conditions that can easily match an analytical approximation. An appropriate estimation of the measurement uncertainty can be obtained through careful design of the instrumentation, thorough uncertainty analysis, and limiting the measurements to only the applicable thermal property ranges of the approach. The 1D model used to interpret measured temperature data has been shown to be reliable for thermal conductivity measurements ranging from at least 0.39 W/mK to 0.92 W/mK and for temperatures from 293-1023 K. The approach is used to present thermal conductivity data of the molten salts NaCl-KCl (51-49 mol%) and LiCl-NaCl (28-72 mol%).
Undesirable Woody Establishment is Driven by Herbaceous Cover Phylogenetics and Abiotic Conditions
Authors: Trejo-Pérez Rolando , Chagnon Pierre-Luc , Gervais-Bergeron Béatrice , Boivin Patrick , Brisson Jacques 
Published: January 2024

Abstract

Revegetation with herbaceous covers is widely used to inhibit tree encroachment in managed areas. However, most studies tend to focus on species selection for inclusion in seed mixtures, neglecting the effect of local contingencies such as soil conditions and native vegetation emerging from the seed bank. Here, we tested the joint effect of sown herbaceous mixtures and local site conditions on the encroachment of undesirable woody species. In a recently cleared right-of-way, we sowed mixtures containing either 3, 5, or 8 species. Over two consecutive years, we allowed spontaneous vegetation to be established. We measured three facets of its diversity: taxonomic, functional and phylogenetic. We also evaluated how woody encroachment was spatially structured and influenced by soil physico-chemical properties. Our study illustrates how successful revegetation strategies for inhibiting tree species should account for both mixture effectiveness in ideal conditions and their ecological versatility (i.e., their ability to regenerate and thrive in various soil types and climatic conditions). The inhibition of woody species also involved multiple mechanisms, with phylogenetic diversity metrics being the dominant predictors of tree encroachment in the first year. However, the significance of abiotic mechanisms intensified in the second year. This temporal shift added complexity to identifying the most effective vegetation management strategies for inhibiting invasive and undesirable species. Hence, an effective prevention of woody species establishment on bare soil sites linked to infrastructure projects necessitates a multifaceted strategy, incorporating not only sown diversity but also a comprehensive understanding of soil properties and resident vegetation diversity.