bluuebunny/crossref_metadata_2025_split huggingface dataset:
Objectively evaluated physical activity among individuals following anterior cruciate ligament reconstruction: a systematic review and meta-analysis
Authors: Manojlovic Marko , Roklicer Roberto , Trivic Tatjana , Carraro Attilio , Gojkovic Zoran , Maksimovic Nemanja , Bianco Antonino , Drid Patrik 
Published: February 2024

ObjectiveTo compare time spent in moderate-to-vigorous physical activity (MVPA) per week, MVPA per day, and steps per day between individuals that were subjected to the anterior cruciate ligament reconstruction (ACLR) and healthy control group.DesignSystematic review and meta-analysis of observational studies.Data sourcesWeb of Science, Scopus, and PubMed have been comprehensively searched to identify relevant investigations.Eligibility criteria for selecting studiesAn observational research that objectively evaluated physical activity among respondents with a history of ACLR.ResultsOf 302 records, a total of 12 studies fulfilled the eligibility criteria. Four hundred and forty-three participants underwent the ACLR, 153 men and 290 women. The mean time between anterior cruciate ligament (ACL) surgery and evaluation of analysed outcomes was 34.8 months. The main findings demonstrated that the ACLR group spent less time in weekly MVPA (standardised mean differences (SMD)=−0.43 (95% CI −0.66 to −0.20); mean = −55.86 min (95% CI −86.45 to −25.27); p=0.0003; τ2=0.00), in daily MVPA (SMD=−0.51 95% CI −0.76 to −0.26]; mean = −15.59 min (95% CI −22.93 to −8.25); p<0.0001; τ2=0.00), and they had fewer daily steps (SMD=−0.60 95% CI −0.90 to −0.30); mean = −1724.39 steps (95% CI −2552.27 to −896.50); p<0.0001; τ2=0.00) relative to their non-injured counterparts. Additionally, available investigations indicated that individuals with a history of ACLR participated in 316.8 min of MVPA per week, 67 min in MVPA per day, and 8337 steps per day.ConclusionLong-term after ACLR, participants undergoing ACL surgery were less physically active compared with their non-injured peers, and they did not satisfy recommendations regarding steps per day.PROSPERO registration numberCRD42023431991
Systemically administered low-affinity HER2 CAR T cells mediate antitumor efficacy without toxicity
Authors: Shabaneh Tamer Basel , Stevens Andrew R , Stull Sylvia M , Shimp Kristen R , Seaton Brandon W , Gad Ekram A , Jaeger-Ruckstuhl Carla A , Simon Sylvain , Koehne Amanda L , Price Jason P , Olson James M , Hoffstrom Benjamin G , Jellyman David , Riddell Stanley R 
Published: February 2024

BackgroundThe paucity of tumor-specific targets for chimeric antigen receptor (CAR) T-cell therapy of solid tumors necessitates careful preclinical evaluation of the therapeutic window for candidate antigens. Human epidermal growth factor receptor 2 (HER2) is an attractive candidate for CAR T-cell therapy in humans but has the potential for eliciting on-target off-tumor toxicity. We developed an immunocompetent tumor model of CAR T-cell therapy targeting murine HER2 (mHER2) and examined the effect of CAR affinity, T-cell dose, and lymphodepletion on safety and efficacy.MethodsAntibodies specific for mHER2 were generated, screened for affinity and specificity, tested for immunohistochemical staining of HER2 on normal tissues, and used for HER2-targeted CAR design. CAR candidates were evaluated for T-cell surface expression and the ability to induce T-cell proliferation, cytokine production, and cytotoxicity when transduced T cells were co-cultured with mHER2+ tumor cells in vitro. Safety and efficacy of various HER2 CARs was evaluated in two tumor models and normal non-tumor-bearing mice.ResultsMice express HER2 in the same epithelial tissues as humans, rendering these tissues vulnerable to recognition by systemically administered HER2 CAR T cells. CAR T cells designed with single-chain variable fragment (scFvs) that have high-affinity for HER2 infiltrated and caused toxicity to normal HER2-positive tissues but exhibited poor infiltration into tumors and antitumor activity. In contrast, CAR T cells designed with an scFv with low-affinity for HER2 infiltrated HER2-positive tumors and controlled tumor growth without toxicity. Toxicity mediated by high-affinity CAR T cells was independent of tumor burden and correlated with proliferation of CAR T cells post infusion.ConclusionsOur findings illustrate the disadvantage of high-affinity CARs for targets such as HER2 that are expressed on normal tissues. The use of low-affinity HER2 CARs can safely regress tumors identifying a potential path for therapy of solid tumors that exhibit high levels of HER2.
Marzo 1821: os movimentos piemonteses de 1821 na obra de Alessandro Manzoni
Authors: Narciso Luiz Felipe dos Santos 
Published: February 2024

O presente artigo tem por objetivo analisar as insurreições e a regência de Carlos Alberto, ocorridas no Piemonte entre março e abril de 1821, bem como a sua representação no poema Marzo 1821 de Alessandro Manzoni. Esta análise terá como objetivo compreender como o escritor, considerado um dos maiores expoentes da literatura italiana, enxergou os movimentos e suas características e, depositou neles suas afeições tanto pessoais quanto patrióticas. Para conduzir este artigo, serão levados em consideração a literatura enquanto prática social (WILLIAMS, 1999), a ideia de providência divina (GHIRARDI, 2006; PARISI, 1999) e os novos paradigmas que o movimento romântico propôs para a literatura e a poesia (LESKI, 2017). Por meio da análise do poema, pode-se concluir que o escritor considerou os movimentos insurrecionais piemonteses como o primeiro passo para a realização do processo de unificação nacional.
moralização em Diodoro Sículo: uma análise da narrativa sobre os eventos de Ducécio
Authors: Viola Leonardo 
Published: February 2024

Diodoro Sículo foi um autor natural da cidade de Agírio, na Sicília, e viveu, aproximadamente, entre os anos 90 e 30 a.C. Escreveu uma obra cujo o nome é “Biblioteca Histórica”. Apesar de se propor a escrever uma obra de cunho moralizante e que abarcasse uma grande linha temporal e espacial, o autor deu especial atenção aos eventos da Sicília. No livro XI são narrados os eventos de Ducécio, um líder sículo (povo nativo da Sicília), e de seu movimento, ocorrido entre os anos 461 e 440 a.C. O presente estudo tem como objetivo una análise do uso, por parte de Diodoro, dos elementos moralizantes, em especial a Týchē (Fortuna), dentro da figura de Ducécio e de suas ações. Ele acaba por ser inserido, assim como outros personagens importantes historicamente para Diodoro, dentro da narrativa moralizante. Diodoro insere suas visões acerca do abuso da Týchē e de como isso poderia afetar a comunidade, pondo mais de um elemento moralizante, afim de educar o leitor de seu tempo.
“Congratulations, you are Being Liberated. Please do not Resist”
Authors: Moran Cian 
Published: February 2024

Abstract
The protection of nationals under international law has long been a controversial one, with various states attempting to justify the deployment of troops under the guise of protecting their citizens. While such interventions were historically acceptable under international law, their contemporary legality is rather more dubious. Such controversy is even more problematic given Russia’s recent invocation of the need to protect Russian citizens as one of its justifications for the invasion of Ukraine in 2022. This article charts the nuances of the protection of nationals under international law before turning to Russia’s own stance on the use of force to protect both Russian citizens and what it deems its “compatriots abroad”, including passportisation. Through careful analysis of both Russia’s foreign policy and international law, it applies the contemporary law relating to the protection of nationals to Russia’s invasions of Georgia in 2008 and Ukraine in 2014 and 2022 and concludes that Russia’s claims to be protecting its nationals have no validity under international law.
An Unpublished Anti-Jewish Syriac Dialogue from Turfan
Authors: Minov Sergey 
Published: February 2024

Abstract
This article presents the unpublished Syriac text of an anonymous anti-Jewish dialogue preserved fragmentarily in the manuscript SyrHT 94 [T II B 50 = 1682] from the Berlin Turfan-Collection. The dialogue, which combines scriptural and rational polemical arguments, is an important witness to the development of the adversus Judaeos literary tradition among Syriac Christians during the Islamic period. The text is accompanied by an English translation and a brief discussion.
The Western Aramaic Context of a Famous Lullaby
Authors: Bromirskaya Anna , Häberl Charles G. , Loesov Sergey 
Published: February 2024

Abstract
The present text concerns a traditional lullaby, sung throughout the Levant in various versions, of which the most famous was produced by the Rahbani brothers and sung by Fairouz. The framing story surrounding the lullaby, which is only implicit in the Rahbani version, concerns themes such as kidnapping and the age-old conflict between transhumant pastoral groups and sedentary agriculturalists. Despite the perennial widespread popularity of the lullaby, aspects of its framing story point to its origins in Maaloula.
The Social and Political Thought of Sayyed ʿ⁠Ali Moḥammad Širāzi, the Bāb
Authors: Abdolmohammadi Pejman 
Published: February 2024

Abstract
Sayyid ʿ⁠Ali Muḥammad Širāzi (1819–50), known as “the Bāb”, is one of the most important modernizers of the 19th century in Iran. He is one of the first thinkers, within the Islamic thought’s modern framework, who challenged the forces of tradition such as the Shiite clergy and the Persian absolute monarchy by offering a new religious view, which went beyond Islamic religion. This article, after a brief reconstruction of the intellectual biography of the Bāb, will analyse his social and political thought, highlighting his main ideas regarding the role of rationality; the role of education and pedagogy; the economy and industrialization; the environment and the importance of civic cohabitation. The article will focus on Bāb’s views concerning the role of the women in the society and the abolition of the clergy from the religious sphere. This work will also show how Bāb’s thought contributed, together with secular and Islamic reformist intellectuals, to the Iranian constitutional revolution (Mašrūṭe) in the early 20th century.
Families Benefit After Utilization of a Clinic-Based Food Pantry Irrespective of Food Insecurity Experiences in a Pediatric Obesity Treatment Program
Authors: Suarez Lilianna , Armstrong Sarah , Fleming Rachel , Howard Janna , Cholera Rushina 
Published: February 2024

Purpose To evaluate the congruence between food insecurity screening outcome and clinic-based food pantry utilization and to examine caregiver reported comfort, motivation, and benefits of utilization. Design Mixed-methods study. Setting Academic pediatric obesity treatment clinic. Subjects Convenience sample of caregivers. Intervention Clinic-based food pantry offered irrespective of food insecurity screening outcome. Measures Food insecurity screening (Hunger Vital Sign) and severity, self-rated caregiver health, willingness to disclose food insecurity and receive food, and food-related stress. Analysis Chi-square and t-tests were utilized to examine associations and descriptive analysis explored benefits. Rapid qualitative analysis was utilized to identify themes. Results Caregivers of 120 children were included (child mean age 11.8; 56.7% female, 67.6% Non-Hispanic Black), with 47 of 59 eligible completing follow-up surveys and 14 completing in-depth interviews. Approximately half (N = 30/59, 50.8%) of families utilizing the food pantry screened negative for food insecurity. Families utilizing the food pantry were more likely to report severe food insecurity (N = 23/59; 38.9%) compared to those declining (N = 3/61; 4.9%, P < .001). Caregivers accepting food were able to meet a child health goal (N = 30/47, 63.8%). Caregivers reported feeling comfortable receiving food (N = 13/14) and felt utilizing the food pantry led to consumption of healthier foods (N = 7/14). Conclusions Families who screened both positive and negative for food insecurity utilized and benefited from a clinic-based food pantry. Clinics should consider strategies offering food resources to all families irrespective of screening outcome.
Non-invasive prediction of the chronic degree of lupus nephropathy based on ultrasound radiomics
Authors: Yin Chen , Xiao Weihan , Hu Xiaomin , Liu Xuebin , Xian Huaming , Su Jun , Zhang Chaoxue , Qin Xiachuan 
Published: February 2024

Objective Through machine learning (ML) analysis of the radiomics features of ultrasound extracted from patients with lupus nephritis (LN), this attempt was made to non-invasively predict the chronicity index (CI) of LN. Methods A retrospective collection of 136 patients with LN who had renal biopsy was retrospectively collected, and the patients were randomly divided into training set and validation set according to 7:3. Radiomics features are extracted from ultrasound images, independent factors are obtained by using LASSO dimensionality reduction, and then seven ML models were used to establish predictive models. At the same time, a clinical model and an US model were established. The diagnostic efficacy of the model is evaluated by analysis of the receiver operating characteristics (ROC) curve, accuracy, specificity, and sensitivity. The performance of the seven machine learning models was compared with each other and with clinical and US models. Results A total of 1314 radiomics features are extracted from ultrasound images, and 5 features are finally screened out by LASSO for model construction, and the average ROC of the seven ML is 0.683, among which the Xgboost model performed the best, and the AUC in the test set is 0.826 (95% CI: 0.681–0.936). For the same test set, the AUC of clinical model constructed based on eGFR is 0.560 (95% CI: 0.357–0.761), and the AUC of US model constructed based on Ultrasound parameters is 0.679 (95% CI: 0.489–0.853). The Xgboost model is significantly more efficient than the clinical and US models. Conclusion ML model based on ultrasound radiomics features can accurately predict the chronic degree of LN, which can provide a valuable reference for clinicians in the treatment strategy of LN patients.
Prioritization decision-making of care in nursing homes: A qualitative study
Authors: Hackman Pauliina , Häggman-Laitila Arja , Hult Marja 
Published: February 2024

Background Prioritization decision-making arises when nurses encounter intricate situations that demand ethically challenging judgments about care. This phenomenon has rarely been studied in nursing homes. Prioritization decision-making may lead to instances where individuals in social and healthcare may not receive all services they need. Making prioritization decisions and awareness of their consequences can increase nurses’ workload. Aim To describe prioritization decision-making regarding unfinished nursing care in nursing homes. Research design A qualitative descriptive study conducted through individual theme interviews. Participants were recruited through social media. The data was analyzed using inductive content analysis. Participants and research context Nurses ( n = 23) working in nursing homes for the elderly people in Finland. Data were collected between June 2022 and February 2023. Ethical considerations Finnish legislation does not mandate an ethical review or research permits, as the participants took part as private individuals. [ask authors to make reference here to informed consent process and anonymity] Findings Nurses stated that the need for prioritization decision-making arises from challenges associated with nurses’ engagement with person-centered care, the culture of the work community, the burden due to workload and challenges associated with the leadership. Prioritization decision-making was based on the interests of residents, striving for an efficient workflow and nurse’s personal interests. Nurses did not receive support for decision-making regarding unfinished care, and protocols for prioritization had not been established in their work communities. Prioritization decision-making and unfinished care were concealed and left unspoken. Conclusion Nursing leaders should address this hidden phenomenon, making it visible through discussions with nurses and by involving them in the development of protocols. The findings can be utilized for developing new approaches to support nurses and reduce their workload and for enhancing the quality and person-centeredness of nursing care in nursing homes.
Feedback Trading and Its Implications for Return Autocorrelations in India During COVID
Authors: Mukherjee Paramita , Chatterjee Rajashri 
Published: February 2024

In emerging capital markets, feedback trading is a widely pursued strategy by investors. Such behavior may potentially lead to volatility and cause negative autocorrelation in market returns, especially during high volatility. In India, such a linkage has not been explored so far, though institutional investors have pursued feedback trading for the last two decades. Also, COVID-19 has led to higher volatility in the markets and might have altered investors’ behavior. This article focuses on finding whether feedback trading is still pursued by institutional investors in Indian equity markets post-COVID and also whether the presence of feedback traders exerts any influence on autocorrelations in market returns. Asymmetric GARCH models are employed to explore the linkage. Findings suggest that while foreign institutional investors continue to pursue positive feedback trading, as in the pre-pandemic period, domestic investors pursue negative feedback trading. However, in the post-pandemic period, as other types of trading became weak or perished, positive feedback traders have started dominating, leading to negative autocorrelation in market returns during heightened volatility. Evidence of negative autocorrelation was not present in the pre-pandemic period. Further, negative news leads to more volatility in returns. JEL Codes: F21, F32, G11
Palliative and End-of-Life Care Interventions with Minoritized Populations in the US with Serious Illness: A Scoping Review
Authors: Varilek Brandon M. , Doyon Katherine , Vacek Shelie , Isaacson Mary J. 
Published: February 2024

Introduction Over the past 20 years, palliative care in the United States has grown significantly. Yet, access to and/or engagement with palliative care for minoritized persons with serious illness remains limited. In addition, the focus of palliative and end-of-life care research has not historically focused on equity-informed intervention development that collaborates directly with minoritized populations. Equity-informed interventions within palliative and end-of-life care research have the potential to champion collaborations with persons with serious illness and their families to mitigate health inequities. The purpose of this scoping review was to examine and describe the literature on the approaches used in the design and development of palliative and end-of-life care interventions with minoritized populations with serious illness. Methods The Joanna Briggs Institute methodology for scoping reviews was followed for tracking and reporting purposes. Included articles were described quantitatively and analyzed qualitatively with content analysis. Results Thirty-seven articles met the inclusion criteria: eight used quantitative methods, eight used qualitative methods, ten reported a community-based participatory research method, nine used mixed-methods, and two had research designs that could not be determined. The qualitative analysis revealed three themes: (1) stakeholder involvement and feedback, (2) intervention focus, and (3) target intervention population (population vs healthcare clinician). Conclusions Using an equity-informed research approach is vital to improve palliative and end-of-life care interventions for minoritized communities with serious illness. There is also a need for more robust publishing guidelines related to community-based participatory research methods to ensure publication consistency among research teams that employ this complex research method.
Real-world data on siponimod-related lymphopenia among people with secondary progressive multiple sclerosis
Authors: Gilmartin Christopher GS , Hoyle Natasha , Garjani Afagh , Dixon Terri , Jos Helena , Paling David , Brownlee Wallace , Tench Christopher , Evangelou Nikos 
Published: February 2024

Background: Siponimod-related lymphopenia in real-world clinical practice has implications for dose adjustment and infection risk. Objective: To characterise siponimod-related lymphopenia in people with secondary progressive multiple sclerosis (pwSPMS). Methods: This is a retrospective cohort of 188 pwSPMS. The development of grade 4 lymphopenia was interrogated with Kaplan–Meier survival analysis and binary logistic regression. Results: Lymphopenia develops soon after commencing siponimod. In total, 15 (8.5%) of 176 experienced grade 4 lymphopenia at 1 month after initiation. There were no clinically significant associations between patient characteristics and development of grade 4 lymphopenia. Conclusion: Grade 4 lymphopenia can occur soon after siponimod initiation and cannot be predicted.
Results of the Double Switch Operation in Patients Who Previously Underwent Left Ventricular Retraining
Authors: Mac Felmly L. , Mainwaring Richard D. , Ho Deborah Y. , Arunamata Alisa , Algaze Claudia , Hanley Frank L. 
Published: February 2024

Background Congenitally corrected transposition of the great arteries (CC-TGA) is a complex form of congenital heart disease that has numerous subtypes. While most patients with CC-TGA have a large ventricular septal defect (VSD) and pulmonary stenosis, there are some patients who have either no VSD or a highly restrictive VSD. These patients will require left ventricular (LV) retraining prior to double switch. The purpose of this study was to review our experience with the double switch procedure in patients who had previously undergone LV retraining. Methods This was a retrospective review of a single institution experience with the double switch procedure in patients who had undergone LV retraining (2002-present). Results Forty-five patients underwent double switch following LV retraining. Of these, 39 had an arterial switch with hemi-Mustard/bidirectional Glenn and six had a Senning. The median cross-clamp time was 135 min (range 71-272) and median bypass time was 202 min (range 140-430 min). Median hospital length of stay was eight days (range 4-108). There were no in-hospital deaths. Median duration of follow-up was 30 months (range 0-175). One patient subsequently underwent heart transplantation and died 65 months following double switch. At follow-up, 41 of the 44 survivors (93%) have normal or low normal LV function and 40 of the 44 survivors (91%) have no or trace mitral regurgitation. Conclusions The data demonstrate early and mid-term survival of 100% and 97%. Ninety-three percent had preserved LV function. These results suggest that patients with CC-TGA who undergo LV retraining and double switch can have excellent clinical outcomes.