bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis
Authors: Wu Shuhui , Zhu Jingjing , Jiang Tingting , Cui Ting , Zuo Qi , Zheng Guibin , Li Guojun , Zhou Jieyu , Chen Xiang 
Published: January 2024

Abstract
Background
Metastasis is the primary cause of recurrence and death in patients with papillary thyroid carcinoma (PTC). LncRNA ACTA2-AS1, a long non-coding RNA, acts as a tumor suppressor in multiple types of human malignancies, while the role of ACTA2-AS1 in PTC metastasis remains unclear.

Methods
The ACTA2-AS1 expression in PTC tissues was analyzed. The sponged roles of ACTA2-AS1 via miR-4428/KLF9 axis were identified using starBase tool. The function of ACTA2-AS1 in PTC was performed with in vitro and in vivo experiments. The correlation between DNA methylation and mRNA expressions of these gene in the TCGA dataset was explored.

Results
ACTA2-AS1 expression was downregulated in PTC tissues without metastasis and further decreased in PTC tissues with lymph node metastasis compared with that in normal tissues. Functionally, the overexpression of ACTA2-AS1 inhibited the growth, proliferation, and invasion of PTC cells, whereas its depletion exerted opposite effect. In vivo, ACTA2-AS1 expression inhibited PTC metastasis. Furthermore, ACTA2-AS1 acted as a competing endogenous RNA for miR-4428, thereby positively regulating the expression of miR-4428 target gene, KLF9. Finally, miR-4428 overexpression enhanced invasive potential of PTC cells and significantly weakened the effects of ACTA2-AS1 on promotion and inhibition of KLF9 expression as well as invasive ability of PTC cells, respectively. In the TCGA dataset, the methylation level of ACTA2-AS1 was significantly correlated with its mRNA expression (r = 0.21, p = 2.1 × e−6).

Conclusions
Our findings demonstrate that ACTA2-AS1 functions as a tumor suppressor in PTC progression at least partly by regulating the miR-4428-dependent expression of KLF9.

Graphical abstract
Determinants of profitability of insurance companies in Ethiopia: evidence from insurance companies from 2011 to 2020 years
Authors: Worku Adam Tsega , Bayleyegne Yenefenta Wube , Tafere Zenebe Berie 
Published: January 2024

AbstractThe profitability of insurance companies has been the focus of several studies within the rise of economies across the countries worldwide. This study aimed to identify determinants of profitability of insurance companies in Ethiopian. The study used nine insurance companies selected by purposive sampling technique among the total 17 insurance companies in Ethiopia from period of 2011 to 2020 based on their establishment. Descriptive, causal research design and quantitative research approach were adopted in carrying out this study. Classical linear regression model under estimation of ordinary least square was employed to identify the determinants of profitability of insurance companies in Ethiopia at 5% level of significance. The classical linear regression model revealed that variable age of the company, tangibility of an asset, size of the company, managerial efficiency, leverage ratio, premium growth and GDP have a positive coefficient relationship with return on asset while loss ratio and inflation have a negative coefficient relationship with return on asset. On the other hand, age of the company size, managerial efficiency, leverage ratio, liquidity ration inflation and premium growth have statistically significant at 5% confidence interval level, whereas the other variables such tangibility of asset and GDP have no statistical significance at 5% confidence interval level. The insurance companies’ previous profit, age of the company, company size, managerial efficiency, leverage ratio, liquidity ratio, loss ratio, premium growth and inflation rate variables are significant key drivers of profitability of Ethiopian insurance companies. Giving due attention to the sector in line with key factors affecting the profitability will improve the overall performance of the insurance companies in Ethiopia.
Improving Bond Performance of Near-Surface Mounted Steel Ribbed and Threated Rods in the Concrete
Authors: Fayed Sabry , Madenci Emrah , Özkiliç Yasin Onuralp , Zakaria Mohamed H. 
Published: January 2024

AbstractIn this study, the experimental findings of twenty pull-out tests on the bond efficiency of threaded/ribbed steel rods used in near-surface mounting (NSM) are presented. On a groove (20 × 20 mm) that was slotted in one of the sides of a concrete block measuring 250 × 250 × 200 mm, a pull-out experiment was performed. The primary factors are the slot-filling materials (substrate concrete and epoxy paste), bonded length (equal to 5, 7, 10, and 15 times the rod diameter), surface pattern conditions (conventional ribbed reinforcing rebar and threaded bolt), use of nuts or rings welded at the free end of the bonded length, and use of straight or spiral wire welded along the length of the bonded length. The tested specimens' ultimate bond strength, slip, bond stress–slip response, failure patterns, stiffness, and ductility are recorded and assessed. The results showed that the ultimate bond strength and corresponding slip of ribbed rods cemented with epoxy were higher by 11.11% and 199%, respectively, than those of ribbed rods submerged in the substrate. Over the controls, all NSM epoxy-rods exhibited a greater ductility. As the bonded length increased, the ultimate bond strength of NSM rods fell by 12–32%. As the bonded length increased, the stiffness decreased. On the other hand, the ductility of NSM epoxy-rods increased as the bonded length increased. All applied schemes such as nuts, rings, longitudinal bars, and spiral bars significantly improved the ultimate bond strength (maximum = 25.93%) and corresponding slip (maximum = 166.67%) of NSM threaded rods as compared to the control ones.
Relation between rheological properties and the stress state in subducting slabs
Authors: Ishii Kazuhiko , Tahara Yuhi , Hirata Kyosuke , Wallis Simon R. 
Published: January 2024

AbstractThe distribution of different stress states in the subducting slab indicated by centroid moment tensor solutions for intra-slab earthquakes can help constrain the rheological properties of the slabs. A comparison of slabs in the western and eastern Pacific realms shows contrasting patterns in the stress states down to depths of ~ 350 km. The majority of slabs in the western Pacific show a pair of down-dip compression (DC) and down-dip tension (DT) domains in the upper and lower parts of the slab reflecting the effects of the slab unbending during progressive subduction. In contrast, slabs in the eastern Pacific show predominantly in-plane DT stress irrespective of slab geometry. Two-dimensional numerical simulations assuming constant slab thickness and viscosity indicate that the development of slabs with in-plane DT stress at depths of 100–300 km requires the slabs to be thin and have a low viscosity (1023 Pa s). Weak slabs bend easily and tend to fold when they encounter increased resistance to downward movement at the 660-km boundary. The associated DC stresses are not transmitted up the slab so negative buoyancy of the slab and DT stress dominates at intermediate depths for this type of slab. Most experimentally derived rheological parameters predict a high viscosity (> 1024 Pa s) for such slabs. However, two-dimensional numerical simulations using temperature- and pressure-dependent viscosity show that a relatively low activation energy (~ 110 kJ/mol) for diffusion creep is a possible explanation for the observed distribution of stresses in the slabs. Such low activation energies are compatible with recent experimental work on diffusion creep of polyphase mantle materials in which a low effective activation energy for creep results from a slow grain growth due to pinning effect of the secondary phase. The simulations provide a mechanical explanation for the observed dominantly DT stress state at 100–300 km depths for young slabs and paired DT and DC stress states at the same depth range for old slabs.
Graphical Abstract
Mapping the landscape of research on insulin resistance: a visualization analysis of randomized clinical trials
Authors: Zyoud Sa’ed H. 
Published: January 2024

Abstract
Background
Insulin resistance, a condition in which cells do not respond adequately to insulin, plays a crucial role in diabetes and related metabolic disorders. Randomized clinical trials (RCTs) explore interventions to manage insulin resistance, contributing to evidence-based medical progress. The current study aimed to analyze the global research landscape and trends in RCTs targeting insulin resistance.

Methods
This study used bibliometric analysis and data visualization to examine RCT publications on insulin resistance from 2003 to 2022. The Scopus database was used due to its comprehensive coverage. The search strategy involved combining terms related to insulin resistance with RCT-related terms. The search query was validated, and core bibliometric indicators were used to analyze publication growth, origin, productivity, quality, and citations.

Results
Between 2003 and 2022, 1077 RCT-focused publications on insulin resistance were identified from a pool of 24,932 related articles. The growth followed two phases, with a significant increase after 2008. The USA (n = 308; 28.60%), Iran (n = 165; 15.32%), China (n = 110; 10.21%), and the UK (n = 92; 8.54%) were the main contributors. The active institutions included Tehran University of Medical Sciences (n = 38; 3.53%) and Harvard Medical School (n = 31; 2.88%). Prominent funding agencies include the National Institutes of Health (n = 88; 8.17%) and the National Institute of Diabetes and Digestive and Kidney Diseases (n = 86; 7.99%). The top journals included the American Journal of Clinical Nutrition (n = 44; 4.09%) and Diabetes Care (n = 35; 3.25%). Co-occurrence analysis revealed three clusters addressing “utilizing lipid panels as indicators of insulin resistance,” “analyzing the impact of diet composition and physical activity on insulin sensitivity among obese individuals,” and “exploring insulin resistance in cases of polycystic ovary syndrome.”

Conclusions
This comprehensive bibliometric analysis highlights the global research landscape and trends in RCTs targeting insulin resistance. Research on lipid panels, diet impact, and insulin resistance in patients with polycystic ovary syndrome will continue to be a hotspot. The findings offer valuable information on research priorities, international collaborations, and impactful publications. This study provides a foundation for future directorial investigations in this critical area of metabolic health.
Racial and Ethnic Inequities at the Practice and Physician Levels in Timely Next-Generation Sequencing for Patients With Advanced Non–Small-Cell Lung Cancer Treated in the US Community Setting
Authors: Vidal Gregory A. , Jain Neha , Fisher Aaron , Sheinson Daniel , Lofgren Katherine T. , Ma Esprit , Yu Elaine , Comment Leah , Miksad Rebecca , Sincan Murat , Martin Richard Lewis , Zuniga Richard , Daniel Davey 
Published: January 2024

PURPOSE
Racial/ethnic inequities in next-generation sequencing (NGS) were examined for patients with advanced non–small-cell lung cancer (aNSCLC) at the practice and physician levels to inform policies to improve equitable quality of care.

METHODS
This retrospective study used a nationwide electronic health record–derived deidentified database for patients with aNSCLC diagnosed between April 2018 and March 2022 in the community setting. Timely NGS was an NGS result between initial diagnosis and ≤60 days after advanced diagnosis. We studied how inequities were driven by (1) non-Latinx Black (Black) and Latinx patient under-representation at high testing practices versus (2) Black and Latinx patients being tested at lower rates than non-Latinx White (White) patients, even at the same practice. We defined these two concepts as across inequity and within inequity, respectively, with total inequity as their summation. Mean percentage point inequities were estimated using a Bayesian approach.

RESULTS

A total of 12,045 patients (9,981 White; 1,528 Black; 536 Latinx) met study criteria. At the practice level, versus White patients, the mean percentage point difference in NGS testing total inequity was 7.49 for Black and 8.26 for Latinx. Within- and across-practice inequities contributed to total inequity in NGS testing for Black (48%
v
52%) and Latinx patients (60%
v
40%). At the physician level, versus White patients, the mean percentage point difference in total inequity was 7.73 for Black and 8.81 for Latinx patients. Within- versus across-physician inequities contributed to total inequity for Black and Latinx patients (77%
v
23% and 67%
v
33%).

CONCLUSION
Within-practice, across-practice, and across-physician inequities were main contributors to total inequity in NGS testing, requiring a suite of interventions to effectively address inequities.
Οι απελευθερωτικές κινήσεις του 1797, οι Γάλλοι και ο Ρήγας
Authors: Koutzakiotis Georges 
Published: January 2024

Les mouvements de libération de 1797, les Français et Rhigas. Une nouvelle lecture à partir de sources inexploitées
Jusqu’à ce jour les mouvements de libération grecs de 1797, qui comprennent évidemment le mouvement de Rhigas Velestinlis et de ses camarades, ont été présentés dans l’historiographie comme des initiatives d’individus ou de groupes isolés. Cette étude examine la relation de ces mouvements non seulement entre eux mais aussi avec les mouvements séparatistes des notables musulmans (ayan) Bus¸atlıs de Shkodër et Osman Pazvantoğlu de Vidin, ainsi que le rôle de Bonaparte et du Directoire dans ces mouvements. Cette approche se fonde principalement sur des témoignages inexploités jusqu’à présent, issus de la correspondance du consul de France à Trieste A. Bréchet et de journaux de Paris, de Francfort et de Wessel.
La Bibliothèque nationale au temps de Van Praet et de Coray
Authors: Perraky Vivi 
Published: January 2024

Η Εθνική βιβλιοθήκη της Γαλλίας την εποχή του Van Praet και του Κοραή. Κανονισμοί, ανέκδοτες επιστολές, κατάστιχα δανεισμού, καταγραφή δανεισθέντων βιβλίων (1799-1833)
Στη μελέτη παρουσιάζονται πενήντα επιστολικά τεκμήρια του Κοραή προς τον Van Praet, διάσημο αρχιβιβλιοθηκάριο στο τμήμα των Εντύπων, «τον ζωντανό κατάλογο της Βιβλιοθήκης»· δύο προς τον Jomard, μέλος της επιτροπής για την Περιγραφή της Αιγύπτου, και ένα προς τον Dacier, τον Διευθυντή της Βιβλιοθήκης.Οι επιστολές –όλες υπογεγραμμένες ως «Coray» και όλες αυτόγραφες εκτός από εκείνη της 9ης Μαΐου 1812– ορίζουν μια νέα επιστολογραφική κατηγορία στο κοραϊκό πεδίο, που συγκροτείται από την πολύχρονη συναλλαγή μεταξύ του λόγιου κι ενός καίριου ακαδημαϊκού θεσμού.H ανάγνωσή τους αφενός φωτίζει περαιτέρω την πνευματική βιογραφία του Κοραή, αφετέρου προβάλλει ανάγλυφα τις κοινωνικές λειτουργίες της Βιβλιοθήκης που απορρέουν από τη μεγάλη θεσμοθετημένη παράδοση στη Γαλλία, η οποία πιστοποιείται ήδη από τον 15ο αιώνα: δηλαδή τον δανεισμό έργων από τη Βιβλιοθήκη τα οποία μπορούσε ο αναγνώστης να ζητήσει γραπτώς να τα πάρει και να τα μελετήσει εκτός του κτιριακού της χώρου. Αν και τα έντυπα αυτά είναι καταγεγραμμένα στα Kατάστιχα δανεισθέντων βιβλίων με παλαιούς ταξινομικούς κωδικούς, η νέα πολυσύνθετη μετατροπή τους σε σύγχρονους κωδικούς καθιστά δυνατή την ταυτοποίησή τους.Η ταυτοποιήση αυτή επιφυλάσσει εκπλήξεις όσον αφορά τα βιβλία που δανειζόταν ο Κοραής, όπως λόγου χάρη αυτά του Spinoza, και δίνει νέα στοιχεία για το καθημερινό βίωμα της φιλολογικής πράξης. Ένα από αυτά είναι η καινοτόμος τεχνική σχολιασμού του Κοραή: όταν τα περιθώρια ενός βιβλίου της Βιβλιοθήκης δεν επαρκούν για τις παρατηρήσεις του, συνεχίζει σε άλλα ανεξάρτητα φύλλα τα οποία προσκολλά με σφραγιστικό κερί. Στην κατοπινή βιβλιοδεσία του εντύπου αυτά τα φύλλα αποκολλήθηκαν και συρράφθηκαν στον τόμο, πράγμα που εξασφαλίζει την απρόσκοπτη διαφύλαξή τους, και μάλιστα στο ακριβές σημείο αναφοράς τους.Αν κι ο Κοραής είχε προβλέψει την επιστροφή post mortem των βιβλίων που είχε δανειστεί από τη Βιβλιοθήκη, και είχε γι’ αυτό επισημάνει στη διαθήκη του τη σύνταξη καταλόγου τους, οι ανασταλτικές συνθήκες της χολέρας του 1832 έδωσαν διαφορετική τροπή στην τελική παράδοσή τους.Η σύγκλιση της φιλολογικής πορείας του Κοραή με τους κανονισμούς που επιτρέπουν την πρόσβαση στο δανεισμό (98 δανεισθέντα έργα) συναρθρώνεται με την ιεραρχική συνθετότητα του ακαδημαϊκού κόσμου της Βιβλιοθήκης, προϊόν της ιστορικά διακεντρωμένης Scholarship στην Ευρώπη· μια δυναμική όπου εγγράφεται εξ ολοκλήρου η προσφορά τουΚοραή στη διασταύρωση δύο ισχυρών παραδόσεων: της διαρκώς επαναπροσδιοριζόμενης λογιοσύνης στη Δύση από τη μια, της συνεχούς εμπορο-ναυτιλιακής κεφαλαιοποίησης στην Ανατολή από την άλλη. Και όλα αυτά διαμεσολαβούνται από την υλικότητα των δανειστικών πρακτικών, η οποία συγκροτεί μορφή ιχνηλάτησης που διαβιβάζεται σε εμάς ως αρχειακή πηγή της εποχής των Van Praet και Κοραή.
Οι ψυχοκοινωνικές δυνάμεις του θάρρους και της αισιοδοξίας: η συμβολή τους στην ενίσχυση της αυτο-αποτελεσματικότητας και στη διαμόρφωση της διαδικασίας λήψης επαγγελματικών αποφάσεων στους εφήβους
Authors: Χαροκοπάκη Αργυρώ , Κάμτσιος Σπυρίδων , Ρούβαλη Βασιλική 
Published: January 2024

Σκοπός της μελέτης ήταν η εξέταση των ψυχοκοινωνικών δυνάμεων του θάρρους και της αισιοδοξίας και η επίδρασή τους στη γενικευμένη αυτο-αποτελεσματικότητα και τη διαδικασία λήψης επαγγελματικών αποφάσεων. Περαιτέρω, η έρευνα αναζήτησε την επίδραση του φύλου και της τάξης φοίτησης στις προαναφερθείσες μεταβλητές. Το δείγμα της έρευνας αποτέλεσαν 232 μαθητές/τριες δευτεροβάθμιας εκπαίδευσης (112 μαθητές και 120μαθήτριες), οι οποίοι συμπλήρωσαν τα παρακάτω ερωτηματολόγια: (α) Κλίμακα Θάρρους (Νorton & Weiss, 2009), (β) Ερωτηματολόγιο για το Νόημα της Ζωής (Steger et al., 2006), (γ) Ερωτηματολόγιο Χαρακτηριστικών Λήψης Επαγγελματικής Απόφασης (Gati etal., 2010) και (δ) Κλίμακα Γενικευμένης Αυτοαποτελεσματικότητας (Jerusalem & Schwarzer, 1992). Από τα αποτελέσματα της μελέτης διαφάνηκε, αρχικά, η επίδραση του φύλου και της τάξης φοίτησης στην κλίμακα του θάρρους, στην αυτοαποτελεσματικότητα καθώς και σε ορισμένες υποκλίμακες του Ερωτηματολογίου Χαρακτηριστικών Λήψης Επαγγελματικής Απόφασης. Περαιτέρω, αναδείχθηκε η στατιστικά σημαντική θετική συσχέτιση του θάρρους με την γενικευμένη αυτοαποτελεσματικότητα και με τις υποκλίμακες «Ταχύτητα λήψης της τελικής απόφασης» και «Επιδίωξη για το ιδανικό επάγγελμα», τις οποίες μπορεί να προβλέψει θετικά και στατιστικά σημαντικά. Επίσης, αναδείχθηκε η αρνητική συσχέτιση του θάρρους με τις υποκλίμακες «Επιθυμία να ευχαριστήσεις τους άλλους-εξάρτηση» και «Αναζήτηση συμβουλής από άλλους» τις οποίες μπορεί να προβλέψει αρνητικά και στατιστικά σημαντικά. Η ψυχοκοινωνική δύναμη της αισιοδοξίας βρέθηκε να έχει θετική συσχέτιση με την υποκλίμακα «Συλλογή και επεξεργασία πληροφοριών» και τη γενικευμένη αυτοαποτελεσματικότητα τις οποίες μπορεί να προβλέψει θετικά. Τα ευρήματα της μελέτης συζητούνται προκειμένου για την αξιοποίησή τους στον σχεδιασμό παρεμβάσεων Επαγγελματικής Συμβουλευτικής που θα συντελέσουν στην ανάπτυξη, καλλιέργεια και αξιοποίηση των συγκεκριμένων ψυχοκοινωνικών δυνάμεων και θα διευκολύνουν την επαγγελματική ανάπτυξη των εφήβων.
The Privacy Paradox and Optimal Bias–Variance Trade-offs in Data Acquisition
Authors: Liao Guocheng , Su Yu , Ziani Juba , Wierman Adam , Huang Jianwei 
Published: January 2024

Whereas users claim to be concerned about privacy, often they do little to protect their privacy in their online actions. One prominent explanation for this privacy paradox is that, when an individual shares data, it is not just the individual’s privacy that is compromised; the privacy of other individuals with correlated data is also compromised. This information leakage encourages oversharing of data and significantly impacts the incentives of individuals in online platforms. In this paper, we study the design of mechanisms for data acquisition in settings with information leakage and verifiable data. We design an incentive-compatible mechanism that optimizes the worst case trade-off between bias and variance of the estimation subject to a budget constraint, with which the worst case is over the unknown correlation between costs and data. Additionally, we characterize the structure of the optimal mechanism in closed form and study monotonicity and nonmonotonicity properties of the marketplace. Funding: This work is supported by the National Natural Science Foundation of China [Grants 62202512 and 62271434], Shenzhen Science and Technology Program [Grant JCYJ20210324120011032], Guangdong Basic and Applied Basic Research Foundation [Grant 2021B1515120008], Shenzhen Key Laboratory of Crowd Intelligence Empowered Low-Carbon Energy Network [Grant ZDSYS20220606100601002], and the Shenzhen Institute of Artificial Intelligence and Robotics for Society. This work is also supported by the National Science Foundation [Grants CNS-2146814, CPS-2136197, CNS-2106403, and NGSDI-2105648]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/moor.2023.0022 .
16QAM optical signal generation scheme based on weighted optimal Euclidean distance
Authors: Xie Rongzhen , Zhang Qi , Xin Xiangjun , Gao Ran , Wang Yun , Tian Qinghua , Tian Feng , Wang Yongjun , Wang Fu , Yang Leijing 
Published: January 2024

A two-dimensional signal constellation scheme for binary uniform memoryless source transmission in optical fiber channels is studied in this paper. In geometric shaping (GS), optimization algorithms are usually used to change the overall position of constellation points while maintaining the probability of constellation points unchanged. Different optimization functions are used to allocate the position of constellation symbols, thereby improving constellation performance. A 16 quadrature amplitude modulation (QAM) optical signal generation scheme based on weighted optimal Euclidean distance is proposed in this paper. In order to obtain the best constellation diagram and increase the shaping gain, the weighted optimal Euclidean distance that can minimize the bit error rate (BER) over multiple iterative optimizations is used as the objective function. On the one hand, the proposed 16QAM optical signal generation scheme based on weighted optimal Euclidean distance always outperforms the uniform square 16QAM and the uniform circle 16QAM schemes in the back to back (BTB) transmission. On the other hand, after analyzing the simulation demonstration in a 50GBaud coherent optical communication system over 3000 km, results demonstrate that the optical signal to noise ratio (OSNR) performance of this system is better than that of the uniform square 16QAM and the uniform circle 16QAM, which is improved by 0.52 dB and 0.85 dB, respectively. In addition, the proposed 16QAM system increases the transmission distance by 989 km and 741 km, respectively, compared to the other two systems. The performance confirms that the proposed novel 16QAM scheme, to the best of our knowledge, can effectively improve the reliability and transmission distance. Therefore, the proposed scheme has a certain development prospect in the future long-distance transmission of high-speed optical fiber communication.