bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing Trends in Diagnosis and Management of Sinusitis in a Large Health Care System: From Primary Care to Otolaryngology
Authors: Hornung Christopher M. , Ganti Ashwin , Lunos Scott , Tyler Matthew A. 
Published: February 2024

Objectives: Variations in management of sinusitis in primary care settings can be associated with inappropriate antibiotic prescriptions and delays in treatment. The objective of this study was to identify patient and provider characteristics associated with possible inaccurate diagnosis and management of sinusitis. Methods: We performed a cross-sectional retrospective analysis using an established regional healthcare database of patients who received a diagnosis of sinusitis between 2011 and 2022 from a non-otolaryngologist provider. Patient’s comorbidities, insurance status, chronicity of sinusitis, and prescriptions were included. We noted if patients were referred to an otolaryngology practice and if they received a diagnosis of sinusitis from an otolaryngologist. Results: We analyzed 99 581 unique patients and 168 137 unique encounters. The mean age was 41.5 (±20.4 years) and 35.7% were male. Most patients had private insurance (88.5%), acute sinusitis (81.2%), and were seen at a primary care office (97.8%). Approximately 30% of patients were referred to an otolaryngology practice for sinusitis. Of referred patients, 50.6% did not receive a diagnosis of sinusitis from an otolaryngology practice. Patients without a sinusitis diagnosis by an otolaryngology practice received significantly more mean courses of antibiotics (5.04 vs 2.39, P < .0001) and oral steroids (3.53 vs 2.08, P < .0001). Conclusions: Over half of the patients referred to an otolaryngology practice from primary care for sinusitis did not receive a diagnosis of sinusitis from an otolaryngology practice. Further research should investigate implications for increased healthcare costs and inappropriate prescription trends associated with the management of sinusitis.
Hepatitis C Virus Testing, Infection, and Cases Reported Through Public Health Surveillance During Expanded Screening Recommendations, United States, 2013-2021
Authors: Ly Kathleen N. , Niles Justin K. , Jiles Ruth B. , Kaufman Harvey W. , Weng Mark K. , Patel Priti , Meyer William A. , Thompson William W. , Thompson Nicola D. 
Published: February 2024

Objectives: Hepatitis C virus (HCV) infection is the most common bloodborne infection in the United States. We assessed trends in HCV testing, infection, and surveillance cases among US adults. Methods: We used Quest Diagnostics data from 2013-2021 to assess trends in the numbers tested for HCV antibody and proportion of positivity for HCV antibody and HCV RNA. We also assessed National Notifiable Diseases Surveillance System 2013-2020 data for trends in the number and proportion of hepatitis C cases. We applied joinpoint regression for trends testing. Results: Annual HCV antibody testing increased from 1.7 million to 4.8 million from 2013 to 2021, and the positivity proportion declined (average, 0.2% per year) from 5.5% to 3.7%. The greatest percentage-point increase in HCV antibody testing occurred in hospitals and substance use disorder treatment facilities and among addiction medicine providers. HCV RNA positivity was stable at about 60% in 2013-2015 and declined to 41.0% in 2021 (2015-2021 average, −3.2% per year). Age-specific HCV RNA positivity was highest among people aged 40-59 years during 2013-2015 and among people aged 18-39 years during 2016-2021. The number of reported hepatitis C cases (acute and chronic) declined from 179 341 in 2015 to 105 504 in 2020 (average decline, −13 177 per year). The proportion of hepatitis C cases among those aged 18-39 years increased by an average of 1.4% per year during 2013-2020; among individuals aged 40-59 years, it decreased by an average of 2.3% per year during 2013-2018. Conclusions: HCV testing increased, suggesting improved universal screening. Various data sources are valuable for monitoring elimination progress.
Impact of the Work Environment on Nurse Outcomes: A Mediation Analysis
Authors: Boudreau Caroline , Rhéaume Ann 
Published: February 2024

Background: The nursing workforce remains in a vulnerable state post pandemic as working conditions are difficult and exacerbated by a global nursing shortage. Identifying factors leading to turnover intentions are thus critical for health care system recovery. Purpose: The purpose of this study was to examine the impact of nurses’ work environment and the pandemic on missed nursing care, scope of practice, emotional exhaustion, and intent to leave. Methods: This study was a cross-sectional, self-reporting online survey, sent to hospital-based nurses in a Canadian province (n = 419). Mediation analysis was used to examine both direct and indirect effects of work environment and COVID-19 impact on nurse outcomes (emotional exhaustion and intent to leave) through missed care and scope of practice. Results: The results showed that 73% of nurses were considering leaving the profession. Several direct and indirect pathways predicted emotional exhaustion and intent to leave. A better work environment was related to both decreased emotional exhaustion and intent to leave. Nurses’ scope of practice partially mediated the relationship between work environment and intent to leave. On the other hand, missed care did not mediate emotional exhaustion or intent to leave. Conclusions: While considering the global nursing shortage, it is imperative to implement strategies to promote nurses’ well-being and their retention within the health care system.
Aortic versus axillary cannulation in acute type A aortic dissection repair: A meta-analysis
Authors: Yamashita Yoshiyuki , Sicouri Serge , Dokollari Aleksander , Rodriguez Roberto , Goldman Scott M. , Ramlawi Basel 
Published: February 2024

Background Research comparing the effectiveness of central aortic cannulation to axillary artery cannulation in repairing acute type A aortic dissection is limited and controversial. This meta-analysis aimed to compare early outcomes of central aortic cannulation versus axillary artery cannulation for surgery for acute aortic dissection type A. Methods A comprehensive systematic search was conducted across PubMed/MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials up to September 1, 2023. The primary endpoints were operative mortality and incidence of postoperative stroke. Secondary endpoints encompassed cardiopulmonary bypass time, myocardial ischemic time, hypothermic circulatory arrest time, postoperative temporary neurological dysfunction, combination of stroke and temporary neurological dysfunction, as well as the need for reexploration for bleeding, renal replacement therapy, and tracheotomy. A random-effect model was utilized to calculate the pooled effect size. Results Eleven studies met our eligibility criteria, enrolling a total of 7204 patients (2760 underwent aortic cannulation and 4444 underwent axillary cannulation). The operative mortality and incidence of postoperative stroke did not show statistical differences between the two groups, with a pooled odds ratio of 1.07 (95% confidence interval: 0.73–1.55) and 1.17 (0.95–1.42), respectively. Similarly, none of the secondary endpoints exhibited significant statistical differences between the two groups. Conclusions Aortic cannulation can be a viable alternative to axillary artery cannulation for repair of acute aortic dissection type A, as both approaches present similar early clinical outcomes.
What is the impact of antidepressant side effects on medication adherence among adult patients diagnosed with depressive disorder: A systematic review
Authors: Niarchou Eleni , Roberts LH , Naughton Bernard D. 
Published: February 2024

Background: Medication adherence is a prerequisite to achieving beneficial treatment outcomes. In major depressive disorder, many patients fail to complete medication regimens, raising concern for poor treatment outcomes. It is usual to experience adverse drug reactions (ADRs) while taking antidepressants, and relative discomfort is reported by patients. Aims: The present review focuses on the presence of antidepressant-related side effects and the subsequent relationship with medication non-adherence. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Following the preliminary research, the research question and eligibility criteria were created based on the PICO framework. All articles retrieved from the selected databases were exported to Covidence, a Systematic Review managing software tool. Two reviewers assessed the papers to identify the risk of bias using the Joanna Briggs Institute critical appraisal tool for cross-sectional studies. Seven studies with a low–moderate risk of bias fulfilled the eligibility criteria and were conducted from 2013 to 2020 in Europe, Africa and Asia. Results: The results demonstrated high levels of suboptimal adherence ranging from 46% to 83% amongst the studied population. A variety of side effects were reported by a significant number of participants predominantly with moderate severity. A correlation between the presence of ADRs and suboptimal rates of adherence to antidepressants was found. Somnolence and headaches among other unspecified ADRs were found to increase the dropout rates for selective serotonin reuptake inhibitors. Conclusions: The present study elucidates the need for effective interventions to facilitate antidepressant adherence and enhance doctor–patient communication, benefiting both the individuals and the healthcare system and leading to better clinical outcomes and reduction of relapse-related costs.
Acontractile detrusor as an initial presentation of sacral spinal cord lesion: Case series
Authors: Abushamma Faris , Abu Alwafa Rola , Aghbar Amir , Maree Mosab , Sweileh Moutaz , Akkawi Maha 
Published: February 2024

Objectives: This study aims to investigate cases of acontractile bladder as the initial presentation of benign and malignant spinal conditions. The focus is on the challenges in making a diagnosis and the importance of a thorough neurological evaluation. Methods: We conducted a retrospective case series involving three patients who exhibited symptoms of acontractile bladder. Detailed clinical histories, urodynamic studies, and imaging techniques such as lumbosacral magnetic resonance imaging (MRI) were analyzed. Histopathological findings from relevant biopsies were also taken into account. Results: Case 1: A 14-year-old female presented with urinary retention, back pain, and an acontractile bladder on urodynamic study. Further examination, including lumbosacral MRI and histopathology, confirmed a diagnosis of metastatic Ewing’s Sarcoma. Case 2: A 39-year-old female with urinary incontinence and elevated post-void residual exhibited delayed bladder sensation. Lumbar spine MRI revealed a grade I Schwannoma after surgical resection. Case 3: A 15-year-old male with lower urinary tract symptoms and an acontractile detrusor on urodynamic study was found to have a Tarlov cyst on lumbosacral MRI. Conclusion: Atonic or Underactive bladder syndrome may be the initial presentation of a serious spinal condition. Complete neurological evaluation is mandatory if no obvious clinical cause.
Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing
Authors: Akter Yeasmin , Islam Md Minhajul , Akter Md Shamim , Afrin Khodeja , Alam Md Saiful , Haque Papia , Bahadur Newaz Mohammed 
Published: February 2024

Multifunctional and biodegradable dressings with high mechanical strength and good antibacterial activity are crucial in fundamental health services. This study was initiated to prepare a novel curative wound dressing film consisting of natural biodegradable gelatin (G) and polylactic acid (PLA) with silver nanoparticles (AgNPs) where glutaraldehyde (GA) was used as compatibilizer. The prepared composite films addressed the poor thermal and biological stability of G and the limited fluid retention capacity of PLA. Silver nanoparticles were prepared by basic chemical reduction and reinforced on polymer films using simple solvent casting, which obviated common clinical infections and accelerated wound closure rate ( p < .05). Fourier transform infrared (FTIR) studies confirmed composite formation through H-bonding and X-ray diffraction (XRD) revealed increased crystallinity due to incorporating AgNPs. Films with G, PLA & GA (50:50:5 by volume) introduced the best elasticity & strength with excellent fluid retention properties ( p < .05). Scanning electron microscopy (SEM) images unfolded surface morphology and presence of agglomerated AgNPs on film surfaces. Prepared films exhibited significant antimicrobial efficacy against Staphylococcus aureus and Pseudomonas sp. and showed excellent cell viability (>97 %) in Vero cell line. Finally, an in vivo mouse model study showed 99.7 % contraction ( p < .05) within 12 days, which was most effectual and 12 % faster than conventional gauge bandages. These results demonstrated the promising and cost-effective potential of the prepared film for wound healing.
Barriers and Facilitators Impacting Disease and Symptom Management Among College Students With Type 1 Diabetes: A Qualitative Study
Authors: McFadden Ny’Nika T. , Wilkerson Amanda H. , Jaiswal Jessica , Chaney Beth H. , Stellefson Michael L. , Carmack Heather J. , Lovett Kylie 
Published: February 2024

Purpose This study aimed to explore barriers and facilitators impacting disease and symptom management among college students living with Type 1 Diabetes (T1D). Design A qualitative, phenomenological approach using semi-structured, one-on-one interviews. Setting Interviews conducted on Zoom (n = 28) and in-person (n = 3). Participants Purposive sample of 31 college students living with T1D for at least 2 years who attended large, 4-year public universities in the Southeastern United States. Method This study was theoretically informed using the Middle-Range Theory of Self-Care of Chronic Illness Integration of Symptoms to develop interview questions. Interviews were transcribed verbatim and uploaded in NVivo. Data were analyzed thematically using a codebook developed by the research team using the theory as a framework. Trustworthiness was established using an audit trail, memos, and negative case analysis. Results Four themes described barriers: diabetes burnout, challenges adjusting to a college lifestyle, difficulty receiving medical supplies, and insurance limitations. Five themes explained facilitators: years of experience managing T1D, tangible support with medical supplies, informational support for disease management, and emotional/technological support for disease and symptom management. Conclusion Barriers and facilitators in this study should be addressed in future T1D interventions for college students. Findings can also guide healthcare professionals, health promotion practitioners, family, friends, and significant others on how to better support college students as they manage T1D.
Nanocomposites of thermoplastic matrices with non-covalent fullerene reinforcement—Structural diversity, physical impact and potential
Authors: Kausar Ayesha , Ahmad Ishaq 
Published: February 2024

Fullerene has been acknowledged as a significant nanocarbon nanofiller enhancing the imperative polymer characteristics. Since, thermoplastic polymers constitute a large group of polymeric materials, fullerene has been used as reinforcement in these matrices mostly via non-covalent means. This state-of-the-art review article summarizes thermoplastic polymer nanocomposites reinforced with fullerene nano-additives without involving any covalent interactions. Accordingly, thermoplastic polymer/fullerene nanocomposites of interest have non-covalent or physical interactions in the matrix-nanofiller such as van der Waals forces, electrostatic interactions, hydrogen bonding, and aromatic stacking interactions. Number of thermoplastic polymers including polyamide, polyurethanes, and block copolymers have been non-covalently or physically reinforced with the fullerene molecules. Ensuing high performance thermoplastic polymer/fullerene nanocomposites exhibited improved microstructure, electrical, mechanical, thermal, and other physical properties. Enhancements in the thermal, mechanical, and electrical properties of the thermoplastic/fullerene nanomaterials were found dependent upon the nanofiller contents, orientations, interfacial effects, and processing. Consequently, the polyamide/fullerene systems were found efficient to enhance the glass transition up to 260°C, in addition to optimum mechanical properties. Polyurethane/fullerene systems performed better for improved tensile strength and young’s modulus features up to 90 MPa and 48 GPa, respectively. System based on poly (methyl methacrylate) and fullerene has resulted in high thermal degradation temperature in the range of 501-633°C with fine electrical conductivity of 1.3 Scm−1. Using combination of fullerene and graphene nanofiller (due to synergistic effects) has been found to improve the electrical conductivity considerably in the range of 1.8–2.5 Scm−1 for a polystyrene and block copolymer system. However, attaining fine fullerene nanoparticle dispersion of non-covalently reinforced matrices have been found important affecting the final nanocomposite properties. Consequently, processability and essential characteristics of non-covalently fullerene filled nanocomposites can be influenced due to nanoparticle aggregation. Hence, the physical property enhancement potential of physical linking between the non-covalently linked thermoplastics-fullerene has been portrayed in this article. Research on non-covalently interacted thermoplastic polymer/fullerene nanocomposites revealed technical potential ranging from energy/electronic devices to engineering and biomedical sectors. This review article can be a useful guide for the field researchers towards the development of advanced systems using non-covalently linked polymer/fullerene nanomaterials for future technical applications.
Power to Detect What? Considerations for Planning and Evaluating Sample Size
Authors: Giner-Sorolla Roger , Montoya Amanda K. , Reifman Alan , Carpenter Tom , Lewis Neil A. , Aberson Christopher L. , Bostyn Dries H. , Conrique Beverly G. , Ng Brandon W. , Schoemann Alexander M. , Soderberg Courtney 
Published: February 2024

Academic Abstract In the wake of the replication crisis, social and personality psychologists have increased attention to power analysis and the adequacy of sample sizes. In this article, we analyze current controversies in this area, including choosing effect sizes, why and whether power analyses should be conducted on already-collected data, how to mitigate the negative effects of sample size criteria on specific kinds of research, and which power criterion to use. For novel research questions, we advocate that researchers base sample sizes on effects that are likely to be cost-effective for other people to implement (in applied settings) or to study (in basic research settings), given the limitations of interest-based minimums or field-wide effect sizes. We discuss two alternatives to power analysis, precision analysis and sequential analysis, and end with recommendations for improving the practices of researchers, reviewers, and journal editors in social-personality psychology. Public Abstract Recently, social-personality psychology has been criticized for basing some of its conclusions on studies with low numbers of participants. As a result, power analysis, a mathematical way to ensure that a study has enough participants to reliably “detect” a given size of psychological effect, has become popular. This article describes power analysis and discusses some controversies about it, including how researchers should derive assumptions about effect size, and how the requirements of power analysis can be applied without harming research on hard-to-reach and marginalized communities. For novel research questions, we advocate that researchers base sample sizes on effects that are likely to be cost-effective for other people to implement (in applied settings) or to study (in basic research settings). We discuss two alternatives to power analysis, precision analysis and sequential analysis, and end with recommendations for improving the practices of researchers, reviewers, and journal editors in social-personality psychology.
Novel Journal Metrics in Cardiothoracic Surgery: How Different Are Contemporary Metrics From the Impact Factor?
Authors: Martins Russell Seth , Ahmed Warda , Barolia Mehak , Poulikidis Kostantinos , Weber Joanna , Latif M. Jawad , Razi Syed Shahzad , Bhora Faiz Y. 
Published: February 2024

Objective: Despite shortcomings, impact factor (IF) remains the “gold standard” metric for journal quality. However, novel metrics including the h-index, g-index, and Altmetric Attention Score (AAS; mentions in mainstream/social media) are gaining traction. We assessed correlations between these metrics among cardiothoracic surgery journals. Methods: For all cardiothoracic surgery journals with a 2021 Clarivate IF ( N = 20), the 2-year IF (2019 to 2020) and 5-year IF (2016 to 2020), h-index, and g-index were obtained. Two-year journal-level AAS (2019 to 2020) was also calculated. Journal Twitter presence and activity was sourced from Twitter and the Twitter application programming interface. Correlations were assessed using Spearman correlation, and coefficients of determination were calculated. Results: IF demonstrated a moderate–strong positive correlation with the h-index ( rs = 0.48 to 0.77) and g-index ( rs = 0.49 to 0.79) and a moderate correlation with AAS ( rs = 0.53 to 0.58). The 2-year IF accounted for 25% to 49% of variability in the h-index, 27% to 55% of variability in the g-index, and 32% of variability in the AAS. Among journals with a Twitter account ( N = 10), IF was strongly correlated with Twitter following ( rs = 0.81 to 0.86), which was in turn strongly correlated with journal AAS ( rs = 0.79). Article-level AAS was moderately correlated with citation count ( rs = 0.47). Conclusions: IF accounted for only between 25% and 55% of variability in the h-index and g-index, indicating that these newer metrics measure unique dimensions of citation-based impact. Thus, the academic community must familiarize itself with these newer journal metrics. Social media attention may be associated with scholarly impact, although further work is needed to understand these relationships.
Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19
Authors: Fleischer Michael , Szepanowski Fabian , Mausberg Anne K , Asan Livia , Uslar Ellen , Zwanziger Denise , Volbracht Lothar , Stettner Mark , Kleinschnitz Christoph 
Published: February 2024

Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge. Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words. Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 ( n = 13), infected but had no PASC ( n = 34), infected with former PASC that resolved ( n = 40) and patients with ongoing PASC after infection ( n = 91). Methods: Cytokine and cortisol serum levels were determined in patients’ blood samples. Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed. Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.