bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital pharmacists’, doctors’ and nurses’ perceptions of intra- and inter- professional communication in the context of electronic prescribing and medication administration systems: A qualitative study
Authors: Mohsin-Shaikh Soomal , Blandford Ann , Franklin Bryony Dean 
Published: November 2023

Background
Effective, integrated and coordinated communication is essential in providing high quality patient care. Little prior research has detailed the impact of electronic prescribing and medication administration (ePMA) systems on healthcare professionals’ (HCPs’) communication. We investigated hospital pharmacists’, doctors’ and nurses’ perceptions of how ePMA systems have affected, or are expected to affect, the way they communicate with each other in an inpatient setting.

Methods
A qualitative study in three English NHS hospitals: two used different inpatient ePMA systems, and one used paper-based prescribing. We conducted focus groups with pharmacists, and semi-structured individual interviews with doctors and nurses. Transcribed data were analysed inductively using thematic analysis.

Results
Nine focus groups, three at each hospital, were conducted with pharmacists with different levels of seniority (58 pharmacists in total). Fourteen doctors and twelve nurses took part in individual interviews. Four themes were generated: modes of communication, reduced pharmacist visibility, system limitations, and future aspirations for ePMA. Whether working with ePMA or paper-based systems, all participants preferred to communicate face-to-face to facilitate collaborative discussions regarding patient care. Participants perceived that ePMA reduced contact time with patients. Pharmacists perceived that both their physical ward presence and their written communication on medication charts had reduced since introduction of ePMA. Doctors felt they were now less likely to ask pharmacists questions due to pharmacists’ reduced physical presence on the ward. Hardware and software limitations were identified by all HCPs, with suggestions made for future developments to better support communication.

Conclusion
ePMA does not necessarily support communication among HCPs. Pharmacists and doctors were also concerned that ePMA reduces communication between themselves and their patients. Hospital managers should ensure sufficient hardware for HCPs, including pharmacists, to conduct their work in clinical areas, and work with ePMA system suppliers to develop ways of enhancing, rather than inhibiting, communication.
Upper glycolytic components contribute differently in controlling retinal vascular endothelial cellular behavior: Implications for endothelial-related retinal diseases
Authors: Oska Nicole , Eltanani Shaimaa , Shawky Mohamed , Naghdi Armaan , Gregory Andrew , Yumnamcha Thangal , Ibrahim Ahmed S. 
Published: November 2023

Background
Retinal degenerative diseases such as diabetic retinopathy and diabetic macular edema are characterized by impaired retinal endothelial cells (RECs) functionality. While the role of glycolysis in glucose homeostasis is well-established, its contributions to REC barrier assembly and cell spreading remain poorly understood. This study aimed to investigate the importance of upper glycolytic components in regulating the behavior of human RECs (HRECs).

Methods
Electric cell-substrate impedance sensing (ECIS) technology was employed to analyze the real-time impact of various upper glycolytic components on maintaining barrier functionality and cell spreading of HRECs by measuring cell resistance and capacitance, respectively. Specific inhibitors were used: WZB117 to inhibit Glut1/3, lonidamine to inhibit hexokinases, PFK158 to inhibit the PFKFB3-PFK axis, and TDZD-8 to inhibit aldolases. Additionally, the viability of HRECs was evaluated using the lactate dehydrogenase (LDH) cytotoxicity assay.

Results
The most significant reduction in electrical resistance and increase in capacitance of HRECs resulted from the dose-dependent inhibition of PFKFB3/PFK using PFK158, followed by aldolase inhibition using TDZD-8. LDH level analysis at 24- and 48-hours post-treatment with PFK158 (1 μM) or TDZD-8 (1 and 10 μM) showed no significant difference compared to the control, indicating that the disruption of HRECs functionality was not attributed to cell death. Conversely, inhibiting Glut1/3 with WZB117 had minimal impact on HREC behavior, except at higher concentrations (10 μM) and prolonged exposure. Lastly, inhibiting hexokinase with lonidamine did not noticeably alter HREC cell behavior.

Conclusion
This study illustrates the unique impacts of components within upper glycolysis on HREC functionality, emphasizing the crucial role of the PFKFB3/PFK axis in regulating HREC behavior. Understanding the specific contributions of each glycolytic component in preserving normal REC functionality will facilitate the development of targeted interventions for treating endothelial cell dysfunction in retinal disorders while minimizing effects on healthy cells.
The effects of tryptophan loading on Attention Deficit Hyperactivity in adults: A remote double blind randomised controlled trial
Authors: Dinu Larisa M. , Singh Samriddhi N. , Baker Neo S. , Georgescu Alexandra L. , Overton Paul G. , Dommett Eleanor J. 
Published: November 2023

Background
Despite the impact and prevalence of Attention Deficit Hyperactivity Disorder (ADHD), current treatment options remain limited and there is a drive for alternative approaches, including those building on evidence of a role for tryptophan (TRP) and serotonin (5-HT). This study aimed to evaluate the effect of acute TRP loading on attention and impulsivity in adults with ADHD.

Trial design and methods
We conducted a remote double blind randomised controlled trial (RCT) using TRP loading to examine the effects of a balanced amino acid load in comparison to low and high TRP loading in individuals with ADHD (medicated, N = 48, and unmedicated, N = 46) and controls (N = 50). Participants were randomised into one of three TRP treatment groups using stratified randomisation considering participant group and gender using a 1:1:1 ratio. Baseline testing of attention and impulsivity using the Test of Variables of Attention Task, Delay Discounting Task, and Iowa Gambling Task was followed by consumption of a protein drink (BAL, LOW, or HIGH TRP) before repeated testing.

Results and conclusions
No effects of TRP were observed for any of the measures. In the present study, TRP loading did not impact on any measure of attention or impulsivity in those with ADHD or Controls. The findings need to be confirmed in another trial with a larger number of patients that also considers additional measures of dietary protein, plasma TRP and aggression. (Registration ID ISRCTN15119603).
PHARMACOGNOSTIC STUDY OF COSMOS BIPINNATUS CAV. (FAM. ASTERACEАE), CULTURED IN THE WESTERN CAUCASIAN REGION
Authors: Kulichenko Evgenia Olegovna , Oganesyan Eduard Tonikovich , Andreeva Ol'ga Andreyevna , Lukashuk Svetlana Pavlovna 
Published: November 2023

The purpose of the work: to reveal the study of the morpho-anatomical composition and composition of biologically active groups – compounds, carboxylic acids and trace elements of the aerial part of various species of Cosmos bipinnatus Cav.: ‘Purity’, ‘Rosea’ and ‘Dazzler’.
Materials and methods. The object of the study is the cultivation of three species of space plants in Europe, collected in the flowering phase at the beginning of 2020. Micropreparations were obtained using a Biomed-2 microscope (eyepiece 16x, objective 4x, 10x) in accordance with the procedures of the State Pharmacopoeia of the Russian Federation, XVI edition (SP XVI). Carbohydrate complexes are isolated from dried raw materials by the method of N.K. Kochetkov and M. Sinner. Quantify the content of each assessment gravimetrically. The monosaccharide composition is established after acid hydrolysis by paper chromatography. Identification of acid consumption is carried out using thin layer chromatography. The elemental and amino acid composition is examined by capillary electrophoresis.
Results and discussion. Certain characteristic microscopic features of Cosmos bipinnatus Cav., Aster varieties ‘Rosea’, ‘Dazzler’, ‘Purity’ for various morphological parts of plants (leaves, flowers, inflorescence involucre, stem), revealing the identified signs of the alleged medicinal source as a source of biologically active connections. A comparative analysis of the composition of carbohydrates, carboxylic acids and carbohydrates of shoots (leaves and stems) showed that water-soluble polysaccharides are arabinose fructose, rhamnose and galactose, pectin monosaccharides are galacturonic acid, glucose and arabinose detection, and hemicelluloses A and B are xylose, glucose and galactose. In all known varieties, succinic acid is noted. A high content of proline and essential amino acids: leucine, methionine, valine, threonine, as well as the ability of all the studied sources to collect potassium, magnesium, iron and boron ions were noted.
Conclusion. It has been established that the unusual colors of the flowers are predominantly the color of the stems. The anatomical features of different species are practically the same. It was revealed that the ‘Purity’ variety surpasses the objects in terms of the content of water-soluble polysaccharides, cellulose-hemi A and B, other essential amino acids, aliphatic amino acids, iron and boron. Variety ‘Dazzler’ is the richest in pectin doses and potassium ions. ‘Rosea’ variety contains the maximum amount of high content of amino acids.
SOURCES AND NATURE OF CRYSTALLINE TURBIDITY OF WINES
Authors: Khrapov Anton Aleksandrovich , Ageeva Natal'ya Mikhaylovna , Sheludko Ol'ga Nikolayevna , Tikhonova Anastasiya Nikolayevna , Chemisova Larisa Eduardovna , Antonenko Mikhail Viktorovich 
Published: November 2023

Introduction. Crystal turbidity in wines is a widespread problem of the wine industry. Violation of the stability and presentation of finished products due to the formation of turbidity and precipitation leads to significant losses of wineries. In various years, up to 25% of all wines produced are prone to the formation of crystalline turbidity. The purpose of this work was to generalize data on the sources of crystalline turbidity, their nature, physico-chemical properties, as well as on the physico-chemical parameters of wine that affect the formation and dissolution of crystalline turbidities.
Objects and methods of research. Domestic and foreign scientific literature on the subject of the study. The analysis, systematization and generalization of the obtained data were used as research methods.
Results and their discussion. The paper presents the main sources of the components of crystalline turbidity, types of crystalline turbidity, their brief characteristics are given, their nature and physico-chemical properties are described, data on the main physico-chemical indicators of wine that influence the formation and dissolution of crystalline turbidity are given. The biological significance, transport and transformation of the components of crystalline turbidities in the grape-must-wine series are described in detail.
Conclusions. At the moment, crystalline turbidity of wines, despite a significant number of ways to control, predict their formation and technological methods to combat them, remain one of the main causes of instability and marketability of wine products. To solve the problem of the formation of crystalline turbidity, it is necessary to conduct a deep fundamental study of their properties, as well as factors influencing their formation and sedimentation in the conditions of a multicomponent composition of wine. The results of the review presented in this article will allow enterprises to develop new approaches in the cultivation and processing of grapes.
ANALYSIS OF SPENT LIQUOR OF LOW-TEMPERATURE ALKALINE DELIGNIFICATION OF HARDWOOD
Authors: Duboviy Vladimir Kliment'yevich , Demiantseva Elena Yurievna , Koverninskij Ivan Nikolaevich 
Published: November 2023

Complex and deep processing of wood raw materials to produce products with high added value while reducing the amount of waste is one of the urgent tasks of the modern pulp and paper industry. The search for economically profitable, but at the same time resource-, energy-saving and environmentally friendly technologies for processing wood raw materials in the modern world is becoming the most important means of ensuring the sustainable development of the industry. An alternative innovative method for the production of high-yield fibrous semi-finished products is the production of an extrusion chemical-thermomechanical mass as a result of low-temperature (90 °C) at atmospheric pressure alkaline delignification of hardwood. The liquor obtained in the process of delignification is a complex complex of mineral compounds and products of destruction of lignin, polysaccharides, extractives and products of their.
Geografía cultural y paisaje ritual en Xochimilco: trabajo de campo en Xochitepec
Authors: Urroz Raquel , Escamilla Fuentes Israel 
Published: November 2023

Este trabajo aplica la perspectiva propuesta por Paul Claval de trabajar con lo experimentado por los habitantes y estudiosos de un paisaje observado. Preocupados por el entorno y la ritualidad, los autores nos relatan un recorrido hasta un cerro ubicado al sur de la Ciudad de México que les permite acercarse a las maneras que una sociedad experimenta su entorno, lo usa, le da significado y actúa sobre él.
Coloquio: Libros de viajes: entre el conocimiento del mundo, la creación y la dominación
Authors: Melo Daniel , Guades de Campo Fernanda Maria , Rendeiro Margarida 
Published: November 2023

Coloquio: Libros de viajes: entre el conocimiento del mundo, la creación y la dominación. Organización: CHAM — Centro de Humanidades / NOVA FCSH – Grupo de Información, Lectura y Formas de Escritura y Grupo de Estudios Transculturales, Literarios e Poscoloniales, en colaboración con la Biblioteca Nacional de Portugal. Coordinación: Daniel Melo, Fernanda Maria Guedes de Campos y Margarida Rendeiro. Auditorio de la Biblioteca Nacional de Portugal, Campo Grande 83, Lisboa, 20 y 21 de septiembre de 2023, 15:00h-18:00h.
Clinical characteristics associated with elevated levels of lipoprotein(a) in patients with vascular risk
Authors: Rubio-Serrano Javier , Gullón Ojesto Alejandra , Suárez Fernández Carmen 
Published: November 2023

Abstract

Objectives
Lipoprotein(a) (Lp(a)) is increasingly used in the evaluation of patients with vascular risk due to its association with cardiovascular events. The purpose of this study was to identify the clinical characteristics of patients with elevated levels of Lp(a) attended in an outpatient vascular risk unit.

Methods
An observational, retrospective study was conducted to assess the clinical characteristics of patients with elevated levels of Lp(a) (≥50 mg/dL), as compared to patients with normal values (<50 mg/dL). The sample was composed of 878 patients identified as having a high vascular risk due to a diagnosis of vascular disease, attended in a vascular risk unit between 2021 and 2022.

Results
The highest levels of Lp(a) were independently associated with a higher probability of having a history of peripheral arterial disease (p=0.024), polygenic familial hypercholesterolemia (PH, p=0.030) and combined familial hypercholesterolemia (CFH, p=0.015); and using PCSK9 inhibitor treatment (p=0.029) and combination therapy with statins and ezetimibe (p=0.018). In contrast, there were no significant differences in relation to familial history of early cardiovascular disease (p=0.143) or personal history of cardiovascular disease (p=0.063), which contrasts with other series.

Conclusions
Elevated levels of Lp(a) were associated with a history of peripheral arterial disease, diagnosis of FHP and CFH, and need for more intense lipid-lowering treatments.
Epistemische Rivalitäten. Zum Umgang mit Sonderwissen an den Höfen des 14. Jahrhunderts
Authors: de Boer Jan-Hendryk , Wallmeyer Gion , Bubert Marcel , Campopiano Michele , Kopp Vanina , Negri Silvia , Neumann Christian Alexander , Pachurka Daniel , Schuh Maximilian 
Published: November 2023

Zusammenfassung
An den Höfen der Könige, Päpste, Fürsten und Fürstinnen entwickelte sich im 14. Jahrhundert eine zunehmende Konkurrenz zwischen Vertreterinnen und Vertretern verschiedener Bestände von Sonderwissen. Die Entscheidung, welches Wissen in welcher Form nutzbar war, verlagerte sich von den gelehrten Milieus auf Laien, an den Höfen auf Herrscher und Herrscherinnen und ihr Umfeld. Der offen ausgetragene Wettbewerb machte es erforderlich, die mit dem jeweiligen Wissensbestand verbundenen Geltungsansprüche, seine Gehalte und seinen möglichen Nutzen sowie die Positionen seiner Trägerinnen und Träger zu überprüfen. Die wachsenden epistemischen Rivalitäten ließen daher Wissen reflexiv werden. Diese Prozesse veranschaulicht der Beitrag anhand von Fallstudien zu ausgewählten lateineuropäischen Höfen.
„Geschichte wird gemacht, es geht voran!“*. William Manchester und die Neuerzählung der Krupp-Geschichte in den 1960er Jahren
Authors: Roelevink Eva-Maria 
Published: November 2023

Zusammenfassung
Der Beitrag nimmt die dominierende und öffentlichkeitswirksame Krupp-Geschichte der 1960er Jahre zum Ausgangpunkt und untersucht die Neuerzählung der Krupp-Geschichte durch den prominenten US-amerikanischen Journalisten William Manchester am Ende der 1960er Jahre. Manchester nahm mit „The Arms of Krupp“ eine Neubewertung vor, die besonders in der Bundesrepublik von den Zeitgenossen kaum beachtet wurde, nicht zuletzt, weil der Krupp-Konzern sich gegen die Veränderung des selbst entwickelten und geschichtsträchtigen Narrativs wehrte. Damit rückt der Wert der „Geschichte“ als PR-Instrument in den Vordergrund. Der Einsatz und die Bewertung der Unternehmensgeschichte wird dabei über das Deutungshandeln der Akteure, von Manchester und dem Krupp-Konzern im Besonderen, herausgestellt.
Der diskrete Charme der Ambivalenz – Atomwaffen und Deutschlands Vereinigung
Authors: Kaiser Karl , Krause Joachim 
Published: November 2023

Kurzfassung
Eine durchgehende Traditionslinie der westdeutschen Außen- und Sicherheitspolitik war der Verzicht auf Atomwaffen und andere Massenvernichtungswaffen. Dieser Verzicht war die Voraussetzung dafür, dass die Westmächte Anfang der 50er-Jahre den Beitritt der jungen Bundesrepublik in die NATO ermöglichten und den Wunsch nach Wiedererlangung der staatlichen Einheit für alle Deutschen unterstützten. Dennoch kennzeichnete Ambivalenz die deutsche Politik. Obwohl Konrad Adenauer keine Ambitionen in Richtung einer eigenen Nuklearbewaffnung hegte, sprach er sich mit dem wiederholten Verweis auf die Rebus-sic-stantibus-Klausel zumindest indirekt dafür aus, Deutschland die nukleare Option offenzuhalten. Seine Nachfolger Ludwig Erhard, Kurt-Georg Kiesinger, Willy Brandt und Helmut Schmidt strebten keine Nuklearbewaffnung an und hielten nicht an der Klausel fest, aber das ambitionierte und breit aufgestellte zivile Nuklearprogramm der Bundesrepublik verschaffte Deutschland eine latente Kernwaffenfähigkeit. Diese erwies sich als hilfreich bei der Ausgestaltung des Nuklearen Nichtverbreitungsvertrags sowie bei der Ausrichtung der Nuklearstrategie der NATO, insbesondere bei der nuklearen Teilhabe. Als sich 1990 die Möglichkeit einer staatlichen Einheit aller Deutschen eröffnete, nutzten die deutschen Verhandlungsführer in den Zwei-plus-Vier-Verhandlungen den uneingeschränkten Verzicht auf Kernwaffen, um die internationale Einbettung der deutschen Einheit im westlichen Bündnis zu erreichen.
Sustainable Ecotourism Berbasis One Stop Service pada Kawasan Dieng
Authors: Budiyono Trivantiko Rezki , Prajanti Sucihatiningsih Dian Wisika 
Published: November 2023

Penelitian ini bertujuan untuk menyusun prioritas strategi dalam pengembangan pariwisata berkelanjutan berbasis one stop service pada Kawasan Wisata Dieng. Desain penelitian ini adalah penelitian mix methods atau gabungan penelitian kuantitatif dan kualitatif. Teknik pengambilan sampel untuk menjawab pertanyaan penelitian kedua (Willingness to Pay) dalam penelitian ini adalah dengan menggunakan sampling insidental. Sedangkan untuk menjawab pertanyaan penelitian ketiga (AHP) dalam penelitian ini dipilih keypersons atau informan menggunakan teknik purposive sampling. Adapun model analisis pertama yang digunakan dalam penelitaian ini adalah metode analisis deskriptif kualitatif, yaitu data yang diperoleh dari suatu penelitian yang telah dilakukan. Metode analisis yang kedua adalah analisis WTP. Untuk mendapatkan nilai WTP pada pengunjung wisata Dieng. Metode analisis yang ketiga adalah Analytical Hierarchy Process (AHP) adalah model pengambilan keputusan yang komprehensif dengan memperhitungkan hal-hal yang bersifat kualitatif dan kuantitatif. Berdasarkan hasil yang dilakukan terhadap responden wisatawan Kawasan Dataran Tinggi Dieng, tidak semua responden bersedia untuk membayar biaya tambahan untuk perawatan lingkungan. Dari total 60 responden wisatawan Kawasan Wisata Dieng dalam penelitian ini, rata-rata sekitar 73,33% responden menyatakan bersedia untuk membayar perbaikan kerusakan lingkungan dari kegiatan pariwisata. Sedangkan sisanya sebesar 26,66% menyatakan tidak bersedia. Berdasarkan hasil analisis AHP, diperoleh hasil bahwa kriteria yang paling diprioritaskan dalam model Strategi dalam pengembangan pariwisata berkelanjutan berbasis one stop service pada Kawasan Wisata Dieng adalah pengembangan sumber daya manusia dengan nilai bobot sebesar 0,493 atau sebesar 49,3%.
Penerapan Manajemen Pencegahan dan Penanggulangan Kebakaran Berdasarakan PERMEN PU Nomor 20/PRT/2009
Authors: Meliza Avisa , Koesyanto Herry 
Published: November 2023

Latar Belakang: Angka kejadian kebakaran di Kota Semarang semakin meningkat setiap tahunnya. Api adalah menghancurkan segala sesuatu yang telah dibangun selama bertahun-tahun dan hancur dalam sekejap, bencana yang cukup ditakuti oleh masyarakat, bisa terjadi kapan saja dimana saja tanpa mengenal waktu dan tempat. Bahkan kejadian kebakaran semakin hari semakin meningkat baik dari segi kuantitas maupun kualitas. Tujuan dari Penelitian ini untuk mengetahui tentang penerapan manajemen pencegahan dan penanggulangan kebakaran berdasarkan Peraturan Menteri Pekerjaan Umum Nomor 20/PRT/M/2009 di Dinas Pemadam Kebakaran Kota Semarang.
Metode: Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Sumber dari Informan dalam penelitian ini adalah bidang pencegahan, bidang sarana dan prasarana dan bidang operasi dan penyelamatan. Instrumen yang digunakan dalam penelitian observasional dan wawancara mendalam.
Hasil: Hasil penelitian menunjukkan bahwa penyediaan air sesuai dengan peraturan tetapi akses masih kurang, air pemadam kebakaran selain air sudah sesuai dengan peraturan, tidak ada penerapan penggunaan hidran, posko pemadam kebakaran sudah merata di setiap kecamatan Kota Semarang, sudah melakukan bekerjasama dengan instansi kepolisian, rumah sakit dan PLN, jumlah kebutuhan air ditentukan oleh naluri sehingga tidak sesuai dengan peraturan. SATLAKAR dan pendidikan belum terlaksana secara merata.
Kesimpulan: Terlaksananya manajemen pencegahan dan pengendalian berdasarkan Peraturan Pemerintah Menteri Pekerjaan Umum Nomor 20/PRT/M/2009 pada Dinas Pemadam Kebakaran Kota Semarang telahsudah dilaksanakan dan ada yang belum dilaksanakan sehingga perlu lebih ditingkatkan lagi dalam bidang pencegahan, bidang sarana dan prasarana , dan di bidang operasi dan penyelamatan
Penanggulangan Penyelamatan, Pencegahan, Sarana dan Prasarana