bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of patients who are admitted under different criteria of the Irish Mental Health Act 2001: a retrospective cohort study
Authors: O’Mahony B.W. , Aylward P. , Cevikel P. , Hallahan B. , McDonald C. 
Published: February 2025

Abstract

Objectives:
To examine the criteria utilised for detaining individuals under the Irish Mental Health Act 2001 (MHA 2001) and their association with clinical features.

Methods:
Demographic and clinical data of 505 involuntary admissions under the MHA 2001 between 2013 and 2023 were attained. Data included criteria utilised for detention and renewal, sociodemographic and clinical features associated with these criteria, and the use of coercive practices, such as seclusion and restraint.

Results:
The majority of patients who were involuntarily admitted (61.4%), or had their admission order affirmed by tribunal (78.2%), were not judged to pose an immediate risk to themselves or others. Patients admitted under the “impaired judgement criterion” were less likely to be secluded (χ2 = 15.8, p < 0.001) or restrained (χ2 = 11.6, p < 0.01). Patients admitted under the “risk criterion” were younger (KW = 12.7, p = 0.02), and less likely to have a psychotic disorder (χ2 = 5.9, p = <0.001) or have a previous involuntary admission (χ2 = 7.7, p = 0.02). Patients who were subject to coercive care were younger (U = 12739, p < 0.001), more likely to be male (χ2 = 4.6, p = 0.03), and have prolonged involuntary admissions (U = 18412, p = 0.02).

Conclusions:
Currently, the majority of the involuntary care provided for patients under the MHA 2001 is not related to the risk criterion of causing immediate and serious harm to themselves or others, but rather to the criterion of impaired judgement. Patients admitted under the risk criterion are more often subjected to restrictive practices, but are less likely to suffer from psychosis, than those receiving involuntary care due to their impaired judgement.
Maladaptive mother–child interactions in mothers with remitted major depression are associated with blunted amygdala responses to child affective facial expressions
Authors: Hindi Attar Catherine , Ridder Neele , Stein Jenny , Kluczniok Dorothea , Dittrich Katja , Jaite Charlotte , Spengler Stephanie , Bödecker Katja , Poppinga Sina , Neukel Corinne , von Schönfeld Judith , Herpertz Sabine , Brunner Romuald , Meyer Kristina , Heinz Andreas , Bermpohl Felix 
Published: February 2025

Abstract

Background
Maternal depression is associated with difficulties in understanding and adequately responding to children’s emotional signals. Consequently, the interaction between mother and child is often disturbed. However, little is known about the neural correlates of these parenting difficulties. Motivated by increasing evidence of the amygdala’s important role in mediating maternal behavior, we investigated amygdala responses to child sad and happy faces in mothers with remitted major depression disorder (rMDD) relative to healthy controls.

Methods
We used the sensitivity subscale of the emotional availability scales and functional magnetic resonance imaging in 61 rMDD and 27 healthy mothers to examine the effect of maternal sensitivity on mothers’ amygdala responses to their children’s affective facial expressions.

Results
For mothers with rMDD relative to controls, we observed decreased maternal sensitivity when interacting with their child. They also showed reduced amygdala responses to child affective faces that were associated with lower maternal sensitivity. Connectivity analysis revealed that this blunted amygdala response in rMDD mothers was functionally correlated with reduced activation in higher-order medial prefrontal areas.

Conclusions
Our results contribute toward a better understanding of the detrimental effects of lifetime depression on maternal sensitivity and associated brain responses. By targeting region-specific neural activation patterns, these results are a first step toward improving the prediction, prevention, and treatment of depression-related negative effects on mother–child interaction.
Altered food liking in depression is driven by macronutrient composition
Authors: Thurn Lilly , Schulz Corinna , Borgmann Diba , Klaus Johannes , Ellinger Sabine , Walter Martin , Kroemer Nils B. 
Published: February 2025

Abstract
Major depressive disorder (MDD) is characterized by changes in appetite and body weight as well as blunted reward sensitivity (‘anhedonia’). However, it is not well understood which mechanisms are driving changes in reward sensitivity, specifically regarding food. Here, we used a sample of 117 participants (54 patients with MDD and 63 healthy control participants [HCPs]) who completed a food cue reactivity task with ratings of wanting and liking for 60 food and 20 non-food items. To evaluate which components of the food may contribute to altered ratings in depression, we tested for associations with macronutrients of the depicted items. In line with previous studies, we found reduced ratings of food wanting (p = .003) but not liking (p = .23) in patients with MDD compared to matched HCPs. Adding macronutrient composition to the models of wanting and liking substantially improved their fit (ps < .001). Compared to carbohydrate-rich foods, patients with MDD reported lower liking and wanting ratings for high-fat and high-protein foods. Moreover, patients with MDD showed weaker correlations in their preferences for carbohydrate- versus fat- or protein-rich foods (ps < .001), pointing to potential disturbances in metabolic signaling. To conclude, our results suggest that depression-related alterations in food reward ratings are more specific to the macronutrient composition of the food than previously anticipated, hinting at disturbances in gut–brain signaling. These findings raise the intriguing question of whether interventions targeting the gut could help normalize aberrant reward signals for foods rich in fat or protein.
Enhanced performance of a parallel manipulator with hybrid joint-space and task-space control approaches
Authors: Sincar Eyyup , Bayraktaroglu Zeki Y. 
Published: February 2025

Abstract
This paper introduces two enhanced control approaches to improve the performance of parallel manipulators, addressing their inherent nonlinear dynamics and complex structure. The first approach results in a hybrid control system in joint space, integrating acceleration-based control, sliding mode, and disturbance observer techniques. The control system is designed to correct tracking errors and compensate for generalized disturbances, thus improving accuracy in tracking reference positions. The second approach merges the joint-space and task-space formulations, implementing proportional-derivative controllers in task space to manage the end-effector positions while maintaining safe operational configurations. The stability of the proposed controllers is demonstrated through Lyapunov analysis, while their performance is validated through comprehensive simulations and real-time experiments.
The impact of collocational proficiency features on expert ratings of L2 English learners’ writing
Authors: Naismith Ben , Juffs Alan 
Published: February 2025

Abstract
Lexical proficiency is a multifaceted phenomenon that greatly impacts human judgments of writing quality. However, the importance of collocations’ contribution to proficiency assessment has received less attention than that of single words, despite collocations’ essential role in language production. This study, therefore, investigated how aspects of collocational proficiency affect the ratings that examiners give to English learner essays. To do so, collocational features related to sophistication and accuracy were manipulated in a set of argumentative essays. Examiners then rated the texts and provided rationales for their choices. The findings revealed that the use of lower-frequency words significantly and positively impacted the experts’ ratings. When used as part of collocations, such words then provided a small yet significant additional boost to ratings. Notably, there was no significant effect for increased collocational accuracy. These findings suggest that low-frequency words within collocations are particularly salient to examiners and deserving of pedagogic focus.
Behind the curtain lies the truth: a case of arrhythmogenic cardiomyopathy mistaken for COVID-19 vaccine-associated myocarditis
Authors: Schaller Samantha , Perry Tanya , Knilans Timothy , Sublet-Smith Juli , Lang Sean , Miller Erin M. , Lorts Angela 
Published: February 2025

Abstract
A 15-year-old male presented with vasovagal syncope and troponin leak 4 days after his second COVID-19 vaccine. Based on initial diagnostic work-up, he was thought to have COVID-19 vaccine-associated myocarditis. His cardiac dysfunction persisted and further work-up including genetic evaluation and serial MRI studies later confirmed a diagnosis of arrhythmogenic cardiomyopathy. This is a unique case of an incorrect diagnosis based on timing and context of vaccine-related myocarditis. Reports of mild and self-limited myocarditis post-COVID-19 vaccination may cause vaccine hesitancy among the public, and so case reports such as this one show the importance of discerning underlying conditions amongst rare COVID-19 vaccination complications.
Hotspots of Global Water Resource Changes and Their Causes
Authors: Lu Jiaxin , Kong Dongdong , Zhang Yongqiang , Xie Yuxuan , Gu Xihui , Gulakhmadov Aminjon 
Published: February 2025

AbstractIn recent decades, terrestrial water storage anomaly (TWSA) has experienced systematic shifts. Despite these observations, debates continue regarding the hotspots where terrestrial water storage changes dramatically and their causes. This study aims to address these controversies. Utilizing four TWSA products, this research analyzes TWSA's changing patterns and identifies hotspots of significant shifts from 1982 to 2019. The study employed the Bayesian Three‐Cornered Hat method to synthesize the best‐quality TWSA from original four TWSA products and the trends consistent method to identify regions with highly consistent trends. Subsequently, the elasticity coefficient method was used to reveal the causes of TWSA's dramatic changes in hotspots. Results show that TWSA has a declining trend over 66.1% global terrestrial areas during 1982–2019, with an average rate of −0.5 mm/y. The study identified six regions where marked changes in TWSA occurred, including Northern China, Southern Canada, Northern India, Central‐Southern Europe, Southwestern Africa, and Northeastern South America. Attribution analysis reveals that the leaf area index is the predominant factor affecting TWSA changes, dominating in 40.3% of global regions. Potential evapotranspiration (PET) follows closely, dominating in 39.8% of global regions. Meanwhile, only 13.1% and 6.8% of global regions are primarily influenced by precipitation and cropland density respectively. The dominant factor varies in different latitudes. Vegetation greening primarily controls TWSA changes in the high‐latitude regions of the Northern Hemisphere. This study identified hotspots of TWSA changes and investigated the causes of these variations. Those results will offer direction for prioritizing areas in future water resource management.
Spatial Distribution of Pc1/EMIC Waves Relative to the Nightside Ionospheric Footprint of the Plasmapause
Authors: Bozóki T. , Heilig B. 
Published: February 2025

AbstractPc1 pulsations cover the 0.2–5 Hz frequency range with electromagnetic ion cyclotron (EMIC) waves of magnetospheric origin being generally accepted as their most important source. In the ionosphere, the initially transverse EMIC waves can couple to the compressional mode and propagate long distances in the ionospheric waveguide. By studying Pc1 waves in the topside ionosphere, we can obtain information on the spatial distribution of both the transverse (incident EMIC) and compressional waves. In the present paper, we make use of a new Swarm L2 product developed for characterizing Pc1 waves to explore the spatial distribution of these waves relative to the midlatitude ionospheric trough (MIT), which corresponds to the ionospheric footprint of the plasmapause (PP) at night. It is shown that the vast majority of Pc1 events are located inside the plasmasphere and that the spatial distributions clearly follow changes in the MIT/PP position at all levels of geomagnetic activity. In the topside ionosphere, the number of transverse Pc1 (incident EMIC) waves rapidly decreases outside the PP, while their occurrence peak is located considerably equatorward (|ΔMlat| = −5° to −15°) of the PP footprint, that is, inside the plasmasphere. On the other hand, the compressional Pc1 waves can propagate in the ionosphere outside the PP toward the poles, while in the equatorial direction there is a secondary maximum in their spatial distribution at low magnetic latitudes. Our results suggest that mode conversion taking place in the inductive ionosphere plays a crucial role in the formation of the presented spatial distributions.
Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial
Authors: Nie Run-Cong , Yuan Shu-Qiang , Ding Ya , Chen Yong-Ming , Li Yuan-Fang , Liang Cheng-Cai , Cai Mu-Yan , Chen Guo-Ming , Wang Wei , Sun Xiao-Wei , Weng De-Sheng , Li Dan-Dan , Zhao Jing-Jing , Chen Xiao-Jiang , Guan Yuan-Xiang , Liu Zhi-Min , Liang Yao , Luo Ma , Chi Jun , Qiu Hai-Bo , Zhou Zhi-Wei , Zhang Xiao-Shi , Chen Ying-Bo 
Published: February 2025

Abstract
This prospective, nonrandomized, open-label phase 2 trial (Chinese Clinical Trial Registry, ChiCTR2200061906) aimed to evaluate the effectiveness of adding the PD-1 antibody tislelizumab to perioperative chemotherapy in patients with locally advanced gastroesophageal junction adenocarcinoma (GEJA). This study enrolled patients with GEJA clinically staged as cT3-4aNanyM0 or cT1-2N+M0 from October 2022 to June 2023. Eligible patients were administered three preoperative and five postoperative 3-week cycles of treatment with PD-1 antibody tislelizumab plus SOX (S-1 and oxaliplatin) regimen. The primary endpoint was major pathological response (MPR) rate. Thirty-two patients were enrolled. The median age was 60 years (range: 28–74 years), and 53.1% (17/32) patients were Siewert III type. All patients received at least one cycle of assigned preoperative treatment, and 93.8% (30/32) patients completed three cycles of assigned preoperative tislelizumab and SOX. The R0 resection rate was 96.9% (31/32). MPR, pathological complete response (pCR) of primary tumors and ypT0N0 rates were 50.0% (16/32, 95% CI: 31.9–68.1%), 28.1% (9/32, 95% CI: 13.7–46.7%) and 25.0% (8/32, 95% CI: 11.5–43.4%), respectively. The surgical morbidity rate was 15.6% (5/32), and no 30-day mortality was observed. In the preoperative and postoperative treatment periods, the rate of treatment-related grade 3–4 adverse events was 31.2% (10/32). At the date of 7th Jan 2025, 8 (25.0%) patients occurred recurrence. Therefore, perioperative tislelizumab plus chemotherapy demonstrated significantly improved pathological regression and might be a promising option for patients with locally advanced resectable GEJA.
Utilisation of subsidised genetic and genomic testing in a publicly funded healthcare system 2014–2023
Authors: Schilling Chris , Sjaaf Florencia , Goranitis Ilias , Dalziel Kim , Martyn Melissa , Stark Zornitza , Gaff Clara 
Published: February 2025

Abstract
The Australian government subsidises medical services, including several genetic and genomic tests, through a federal funding scheme. We explore trends and variation in the utilisation of the publicly funded genetic and genomic tests over the last decade. We make use of administrative data of the listed genetic and genomic tests from financial year 2014 to 2023. In 2023, 102 genetic and nine genomic tests were publicly subsidised across 65 distinct clinical test indications, up from 32 items across 20 distinct tests in 2014. Service volumes have increased by 50% from 250,881 to 376,140, and benefits paid have risen by 83% from AU$42.0 million to AU$76.8 million. This accounts for 0.3% of the total AU$27.6 billion expenditure on publicly subsidised medical services in 2023. Somatic cancer, rare disease, and reproductive tests are the most prevalent tests. Women of childbearing ages used more services than men, however in nonchildbearing ages, men used more services than women. The current usage of publicly funded genetic and genomic testing within Australia is relatively modest, underscoring challenges in integration to routine clinical practice. However, the recent rapid expansion of subsidised items indicates that investments into genomics research are beginning to yield the evidence necessary to secure public funding for these services.
The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial
Authors: Block Matthew Stephen , Clubb James Hugo Armstrong , Mäenpää Johanna , Pakola Santeri , Quixabeira Dafne Carolina Alves , Kudling Tatiana , Jirovec Elise , Haybout Lyna , van der Heijden Mirte , Zahraoui Sanae , Grönberg-Vähä-Koskela Susanna , Raatikainen Sini , Arias Victor , Basnet Saru , Ojala Nea , Pellinen Teijo , Hemmes Annabrita , Välimäki Katja , Pasanen Annukka , Alanko Tuomo , Adamo Daniel , Ramadan Susan , Sormunen Jorma , Kononen Juha , Cohen Julia Wanda , Chisamore Michael Jon , Goldfinch John , Sorsa Suvi , Havunen Riikka , Kistler Claudia , Kalervo Aino , Cervera-Carrascon Víctor , dos Santos João Manuel , Hemminki Akseli 
Published: February 2025

Abstract
Immune checkpoint inhibitors have demonstrated modest efficacy as a monotherapy in ovarian cancer. Originally developed to improve efficacy of T-cell therapies such as immune checkpoint inhibitors and adoptive cell transfer, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) is a serotype chimeric oncolytic adenovirus encoding tumor necrosis factor alpha and interleukin-2. Here we report results from phase 1a of PROTA, a single-arm, multicentre dose escalation trial with TILT-123 and pembrolizumab in female patients with platinum resistant or refractory ovarian cancer (NCT05271318). The primary endpoint was safety. Secondary endpoints included efficacy, tolerability, virus persistence and anti-viral immunity. Patients (n = 15) received intravenous and intraperitoneal and/or intratumoral injections of TILT-123 as well as intravenous pembrolizumab. Treatment was well tolerated, and no dose-limiting toxicities were observed. The most frequent adverse events were fever (40%), fatigue (40%) and nausea (40%). Disease control was achieved in 64% of evaluable patients (9/14). Median progression-free survival and overall survival were 98 and 190 days respectively. Clinical responses were associated with higher serum anti-adenovirus neutralizing antibody titer at baseline and post-treatment. The phase 1b investigating TILT-123, pembrolizumab and PEGylated liposomal doxorubicin in a similar patient population is underway.
Molecular characterization of Pseudomyxoma peritonei with single-cell and bulk RNA sequencing
Authors: Ha Ye Jin , Park Seong-Hwan , Kim Seon-Kyu , Tak Ka Hee , Kim Jeong-Hwan , Kim Chan Wook , Yoon Yong Sik , Kim Seon-Young , Lee Jong Lyul 
Published: February 2025

Abstract
Pseudomyxoma peritonei (PMP), a rare condition characterized by mucinous ascites in the peritoneal cavity, often leads to a poor prognosis. However, omics profiling of this disease remains significantly underexplored. Here, we present single-cell transcriptomic profiling of five PMP cases to identify cell type-specific gene features associated with PMP pathogenesis. Additionally, we provide bulk RNA-seq datasets from two independent cohorts: 19 fresh frozen tissue samples (12 PMPs) and 34 formalin-fixed paraffin-embedded (FFPE) samples (25 PMPs). We also offer protein expression data from a tissue microarray (TMA) analysis of 90 samples (45 PMPs). Our single-cell and bulk transcriptomic profiles, along with TMA verifications, reveal the cellular diversity of PMP, highlighting the coexistence of epithelial and mesenchymal characteristics within PMP cells. These datasets enhance our understanding of PMP pathogenesis and provide a valuable resource for uncovering the intricate molecular landscape of PMP, with the potential to improve clinical utility through further research.
Taphonomic variation in vascular remains from Mesozoic non-avian dinosaurs
Authors: Schweitzer M. H. , Zheng W. , Dickinson E. , Scannella J. , Hartstone-Rose A. , Sjövall P. , Lindgren J. 
Published: February 2025

Abstract
The identity and source of flexible, semi-transparent, vascular-like components recovered from non-avian dinosaur bone are debated, because: (1) such preservation is not predicted by degradation models; (2) taphonomic mechanisms for this type of preservation are not well defined; and (3) although support for molecular endogeneity has been demonstrated in select specimens, comparable data are lacking on a broader scale. Here, we use a suite of micromorphological and molecular techniques to examine vessel-like material recovered from the skeletal remains of six non-avian dinosaurs, representing different taxa, depositional environments and geological ages, and we compare the data obtained from our analyses against vessels liberated from extant ostrich bone. The results of this in-depth, multi-faceted study present strong support for endogeneity of the fossil-derived vessels, although we also detect evidence of invasive microorganisms.
A modified energy management strategy for PV/diesel hybrid system to reduce diesel consumption based on artificial protozoa optimizer
Authors: Mohamed Rania G. , Hassan Amal A. , Abdel Aleem Shady H. E. 
Published: February 2025

Abstract
The photovoltaic (PV)/diesel hybrid system (PV/D-HS) combines solar PV panels with a diesel generator (DG) to meet energy demands, especially in industrial operations. This study introduces an improved energy management strategy designed to optimize the performance of PV/D-HS by reducing diesel consumption, increasing solar energy utilization, and minimizing environmental impact. The strategy dynamically manages power distribution between the PV panels and the DG, adapting to changing solar conditions and energy demands. Doing so reduces the system’s reliance on diesel, improves operational efficiency, and supports the integration of cleaner energy sources. Simulation results show significant improvements over traditional approaches: carbon emissions decreased from 62 kg/day with a standalone diesel generator to 38 kg/day, representing a 38% reduction. The solar energy fraction (SEF) increases from 12 to 35%, a 23% improvement in solar energy utilization. These results demonstrate the potential of the proposed strategy to enhance sustainability by lowering greenhouse gas emissions, reducing dependence on fossil fuels, and advancing global efforts to combat climate change. In addition to environmental benefits, the approach reduces operational costs and improves the system’s reliability, making it a practical solution for industrial energy needs.