bluuebunny/crossref_metadata_2025_split huggingface dataset:
From assistive to inclusive? A systematic review of the uses and effects of technology to support people with pervasive support needs
Authors: Piekema Lotte , ten Brug Annet , Waninge Aly , van der Putten Annette 
Published: January 2024

AbstractBackgroundAlthough particular technologies can enhance the quality of life (QoL) of people with profound intellectual and multiple disabilities (we use the term pervasive support needs), their objectives and outcomes are understudied. A systematic literature review was therefore conducted to explore this topic.MethodA search of four databases yielded 64 studies. Data were extracted on their general characteristics, methods and sample characteristics as well as the technology types, QoL domains and application within ecological systems. A narrative synthesis was subsequently developed.ResultsMost of the studies applied assistive technology (AT) and focused on personal development and self‐determination on an individual level.ConclusionsTechnology can enhance the QoL of people with pervasive support needs. There are indications that although MT and UD‐based technology are used in practice, few studies have examined these technologies. Therefore, there is a knowledge gap regarding the kinds of technology that are used in practice.
Utilization of remote reprogramming to manage insertable cardiac monitor arrhythmia alert burden
Authors: Seiler Amber , Rosemas Sarah , Zhou Jiani , Franco Noreli , Rogers John 
Published: January 2024

AbstractIntroductionThe increasing use of insertable cardiac monitors (ICMs) for long‐term continuous arrhythmia monitoring creates a high volume of transmissions and a significant workload for clinics. The ability to remotely reprogram device alert settings without in‐office patient visits was recently introduced, but its impact on clinic workflow compared to the previous ICM iteration is unknown.MethodsThe aim of this real‐world study was to evaluate the impact of device reprogramming capabilities on ICM alert burden and on clinic workflow. Deidentified data was obtained from US patients and a total of 19 525 receiving a LINQ II were propensity score‐matched with 19 525 implanted with LINQ TruRhythm (TR) ICM based on age and reason for monitoring.ResultsAfter reprogramming, ICM alerts reduced by 20.5% (p < .001). Compared with patients monitored with LINQ TR, patients with LINQ II had their device reprogrammed sooner after implant and more frequently during follow‐up. Adoption of remote programming was projected to lead to an annual total clinic time savings of 211 h per 100 ICM patients managed.ConclusionThese data suggest that utilization of ICM alert reprogramming has increased with remote capabilities, which may reduce clinic and patient burden for ICM follow‐up and free clinician time for other valuable patient care activities.
Cav‐1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα‐associated signalling under cholesterol stimulation
Authors: Pang Liwei , Cui Meiying , Wu Shuodong , Kong Jing 
Published: January 2024

AbstractBackground and AimsThe secretion of bile salts transported by the bile salt export pump (BSEP) is the primary driving force for the generation of bile flow; thus, it is closely related to the formation of cholesterol stones. Caveolin‐1 (Cav‐1), an essential player in cell signalling and endocytosis, is known to co‐localize with cholesterol‐rich membrane domains. This study illustrates the role of Cav‐1 and BSEP in cholesterol stone formation.MethodsAdult male C57BL/6 mice were used as an animal model. HepG2 cells were cultured under different cholesterol concentrations and BSEP, Cav‐1, p‐PKCα and Hax‐1 expression levels were determined via Western blotting. Expression levels of BSEP and Cav‐1 mRNA were detected using real‐time PCR. Immunofluorescence and immunoprecipitation assays were performed to study BSEP and Hax‐1 distribution. Finally, an ATPase activity assay was performed to detect BSEP transport activity under different cholesterol concentrations in cells.ResultsUnder low‐concentration stimulation with cholesterol, Cav‐1 and BSEP protein and mRNA expression levels significantly increased, PKCα phosphorylation significantly decreased, BSEP binding capacity to Hax‐1 weakened, and BSEP function increased. Under high‐concentration stimulation with cholesterol, Cav‐1 and BSEP protein and mRNA expression levels decreased, PKCα phosphorylation increased, BSEP binding capacity to Hax‐1 rose, and BSEP function decreased.ConclusionCav‐1 regulates the bile salt export pump on the canalicular membrane of hepatocytes via PKCα‐associated signalling under cholesterol stimulation.
Resveratrol differentially affects MMP‐9 release from neurons and glia; implications for therapeutic efficacy
Authors: Amontree Matthew , Nelson Matthew , Stefansson Lara , Pak Daniel , Maguire‐Zeiss Kathleen , Turner R. Scott , Conant Katherine 
Published: January 2024

AbstractResveratrol, a naturally occurring polyphenol that activates sirtuin 1 (SIRT1), has been shown to reduce overall levels of matrix metalloprotease‐9 (MMP‐9) in cerebrospinal fluid (CSF) samples from patients with Alzheimer's dementia (AD). Depending on the site of release, however, MMP‐9 has the potential to improve or impair cognition. In particular, its release from microglia or pericytes proximal to the blood brain barrier can damage the basement membrane, while neuronal activity‐dependent release of this protease from glutamatergic neurons can instead promote dendritic spine expansion and long‐term potentiation of synaptic plasticity. In the present study, we test the hypothesis that resveratrol reduces overall MMP‐9 levels in CSF samples from patients with APOE4, an allele associated with increased glial inflammation. We also examine the possibility that resveratrol reduces inflammation‐associated MMP release from cultured glia but spares neuronal activity‐dependent release from cultured cortical neurons. We observe that resveratrol decreases overall levels of MMP‐2 and MMP‐9 in CSF samples from AD patients. Resveratrol also reduces CSF levels of tissue inhibitor of metalloproteinases‐1 (TIMP‐1), glial‐derived protein that restricts long‐term potentiation of synaptic transmission, in individuals homozygous for APOE4. Consistent with these results, we observe that resveratrol reduces basal and lipopolysaccharide (LPS)‐stimulated MMP and TIMP‐1 release from cultured microglia and astrocytes. In contrast, however, resveratrol does not inhibit release of MMP‐9 from cortical neurons. Overall, these results are consistent with the possibility that while resveratrol reduces potentially maladaptive MMP and TIMP‐1 release from activated glia, neuroplasticity‐promoting MMP release from neurons is spared. In contrast, resveratrol reduces release of neurocan and brevican, extracellular matrix components that restrict neuroplasticity, from both neurons and glia. These data underscore the diversity of resveratrol's actions with respect to affected cell types and molecular targets and also suggest that further studies may be warranted to determine if its effects on glial MMP release could make it a useful adjunct for AD‐ and/or anti‐amyloid therapy‐related damage to the blood brain barrier.image
Surgical correction of sunken upper eyelid with upper arcus marginalis release and precision fat distribution technique
Authors: Hong Sa‐Hyeok , Choi Nakwon , Baek Rong‐Min , Kim Jong‐Ho 
Published: January 2024

AbstractBackgroundSunken upper eyelids, characterized by hollowing in the upper orbital region, can contribute to an aged or fatigued appearance. We aim to report on the surgical technique and its effects, involving the release of the arcus marginalis of the upper eyelid and the precise distribution of orbital fat.MethodsFrom December 2021 to March 2023, a total of 84 eyelids from 42 patients who underwent surgical correction for sunken upper eyelids, utilizing the upper arcus marginalis release and precision fat distribution technique, were included in this study. Preoperative and postoperative sunken depths were measured and statistically analyzed. Aesthetic satisfaction was assessed through patient questionnaires.ResultsPreoperative and postoperative sunken depths measured 9.2 ± 2.2 mm and 5.9 ± 2.3 mm, respectively. The mean improvement was 3.3 mm, a change of statistical significance. Aesthetic outcomes and patient satisfaction yielded favorable results. No major complications were observed during the follow‐up period.ConclusionThe upper arcus marginalis release and orbital fat distribution technique demonstrated favorable outcomes in correcting sunken upper eyelids. This procedure ensures stable placement of orbital fat at the deepest sunken point, resulting in aesthetically pleasing and enduring results. This technique serves as a valuable alternative for patients with moderate to severe sunken eyelids.
Investigation of optimal weight gain during pregnancy: A retrospective analysis of the Japanese perinatal registry database
Authors: Takeda Jun , Morisaki Naho , Itakura Atsuo , Aoki Shigeru , Sago Haruhiko , Nagamatsu Takeshi , Masuyama Hisashi , Matsubara Shigeki , Umazume Takeshi , Mitsuda Nobuaki , Itoh Hiroaki , Ikeda Tomoaki ,   Perinatal Committee of the Japanese Society of Obstetrics and Gynecology
Published: January 2024

AbstractAimThis study aimed to determine the weight gain during pregnancy that minimizes the predicted probability of various perinatal adverse events according to the pre‐pregnancy body mass index (BMI) and make recommendations for optimal weight gain in Japan.MethodsThe Japan Society of Obstetrics and Gynecology perinatal database for 2015–2017 was used. From the 719 723 deliveries included in this database, parturients with underlying diseases or missing data were excluded, and 419 114 deliveries were analyzed. A questionnaire survey was also conducted to weigh each perinatal adverse event. For each of the nine outcomes, a restricted cubic spline model was made to estimate the association between the “expected gestational weight gain at 40 weeks” and the outcome risk.ResultsSince the classes of medical facilities were generally the same, weights were assigned according to the mean of the questionnaires rather than by the class of the facility. For each pre‐pregnancy BMI, the weight gains during pregnancy that minimized the predicted probability of various adverse perinatal events were 12–15, 10–13, 7–10, and upper limit of 5 kg for the underweight, normal‐weight, obese 1, and obese ≥2 groups, respectively.ConclusionsThe weight gain during pregnancy that minimizes the predicted probability of various perinatal adverse events according to the pre‐pregnancy BMI was established.
Green leaf volatiles co‐opt proteins involved in molecular pattern signalling in plant cells
Authors: Tanarsuwongkul Sasimonthakan , Fisher Kirsten W. , Mullis B. Todd , Negi Harshita , Roberts Jamie , Tomlin Fallon , Wang Qiang , Stratmann Johannes W. 
Published: January 2024

AbstractThe green leaf volatiles (GLVs) Z‐3‐hexen‐1‐ol (Z3‐HOL) and Z‐3‐hexenyl acetate (Z3‐HAC) are airborne infochemicals released from damaged plant tissues that induce defenses and developmental responses in receiver plants, but little is known about their mechanism of action. We found that Z3‐HOL and Z3‐HAC induce similar but distinctive physiological and signaling responses in tomato seedlings and cell cultures. In seedlings, Z3‐HAC showed a stronger root growth inhibition effect than Z3‐HOL. In cell cultures, the two GLVs induced distinct changes in MAP kinase (MAPK) activity and proton fluxes as well as rapid and massive changes in the phosphorylation status of proteins within 5 min. Many of these phosphoproteins are involved in reprogramming the proteome from cellular homoeostasis to stress and include pattern recognition receptors, a receptor‐like cytoplasmic kinase, MAPK cascade components, calcium signaling proteins and transcriptional regulators. These are well‐known components of damage‐associated molecular pattern (DAMP) signaling pathways. These rapid changes in the phosphoproteome may underly the activation of defense and developmental responses to GLVs. Our data provide further evidence that GLVs function like DAMPs and indicate that GLVs coopt DAMP signaling pathways.
Systemic stomatal responses in plants: Coordinating development, stress, and pathogen defense under a changing climate
Authors: Peláez‐Vico María Ángeles , Zandalinas Sara I. , Devireddy Amith R. , Sinha Ranjita , Mittler Ron 
Published: January 2024

AbstractTo successfully survive, develop, grow and reproduce, multicellular organisms must coordinate their molecular, physiological, developmental and metabolic responses among their different cells and tissues. This process is mediated by cell‐to‐cell, vascular and/or volatile communication, and involves electric, chemical and/or hydraulic signals. Within this context, stomata serve a dual role by coordinating their responses to the environment with their neighbouring cells at the epidermis, but also with other stomata present on other parts of the plant. As stomata represent one of the most important conduits between the plant and its above‐ground environment, as well as directly affect photosynthesis, respiration and the hydraulic status of the plant by controlling its gas and vapour exchange with the atmosphere, coordinating the overall response of stomata within and between different leaves and tissues plays a cardinal role in plant growth, development and reproduction. Here, we discuss different examples of local and systemic stomatal coordination, the different signalling pathways that mediate them, and the importance of systemic stomatal coordination to our food supply, ecosystems and weather patterns, under our changing climate. We further discuss the potential biotechnological implications of regulating systemic stomatal responses for enhancing agricultural productivity in a warmer and CO2‐rich environment.
Inorganic carbon sensing and signalling in cyanobacteria
Authors: Kurkela Juha , Tyystjärvi Taina 
Published: January 2024

AbstractCyanobacteria utilize CO2 and HCO3− as inorganic carbon (Ci) sources. In low Ci, like in ambient air, cyanobacteria efficiently collect Ci using a carbon concentrating mechanism (CCM). The CCM includes bicarbonate transporters SbtA, BicA and BCT1; the specialized NDH complexes NDH‐13 and NDH‐14, which convert CO2 to HCO3− in the cytoplasm; and carboxysomes that are protein shell encapsulated ribulose‐1,5‐bisphosphate carboxylase/oxygenase (RuBisCo) and carbonic anhydrase containing bodies in which the first reaction of carbon fixation occurs. Ci‐dependent regulation of bicarbonate transporters and specialized NDH complexes, especially the regulation of the SbtA transporter, are well understood. CcmR (also called NdhR), CyAbrB2, CmpR and RbcR act as transcription factors regulating CCM genes. Ci signalling molecules detecting the metabolic status of the cells include 2‐oxoglutarate, which accumulates when the Ci/nitrogen ratio of the cell is high, and 2‐phosphoglycolate, the first intermediate of the photorespiration pathway, whose accumulation indicates low Ci. These signalling molecules act as corepressors and coactivators of the CcmR repressor protein, whereas 2‐phosphoglycolate and ribulose‐1,5‐bisphosphate activate transcription activator CmpR. In addition, bicarbonate or CO2 activates the adenylyl cyclase that produces cAMP, and ATP/ADP/AMP provide information about the energy status of the cell. Less is known about the molecular mechanisms regulating carboxysome dynamics or how production, activity and degradation of photosynthetic complexes are regulated by prevailing Ci conditions or which mechanisms adjust cell division according to Ci. This minireview summarizes the present knowledge about molecular mechanisms regulating cyanobacterial acclimation to prevailing Ci.
The effect of the working correlation on fitting models to longitudinal data
Authors: Muller Samuel , Wang Suojin , Welsh A. H. 
Published: January 2024

AbstractWe present a detailed discussion of the theoretical properties of quadratic inference function estimators of the parameters in marginal linear regression models. We consider the effect of the choice of working correlation on fundamental questions including the existence of quadratic inference function estimators, their relationship with generalized estimating equations estimators, and the robustness and asymptotic relative efficiency of quadratic inference function and generalized estimating equations estimators. We show that the quadratic inference function estimators do not always exist and propose a way to handle this. We then show that they have unbounded influence functions and can be more or less asymptotically efficient than generalized estimating equations estimators. We also present empirical evidence to demonstrate these results. We conclude that the choice of working correlation can have surprisingly large effects.
Taxonomic status of hares (Lepus spp.) in Xinjiang, China (Lagomorpha: Leporidae): An integrative approach
Authors: Shan Wen‐Juan , Li Zu‐Rui , Dai Hui‐Ying , Dong Peng‐Cheng , Zhang Yu‐Cong 
Published: January 2024

AbstractThe taxonomic status and interspecies relationships of hares (genus Lepus) in Xinjiang, China, remain ambiguous owing to extremely similar external morphologies, introgressive hybridization between species and a lack of molecular genetic records. In this study, a total of 154 hare specimens were used to clarify their taxonomic status. Based on multiple lines of evidence, including observations and comparisons of external morphological characteristics, skull morphometrics and genome‐wide single nucleotide polymorphism (SNP) datasets, four hare species were recognised. Lepus yarkandensis and Lepus timidus, which have obvious morphological characteristics, were identified as two distinct species, as previously reported. Combining the integrated morphological and molecular datasets with the relevant literature, we proposed suggestions on the classification of the more controversial hares. Due to molecular and morphological similarities, hares in northern and central Xinjiang were divided into two subspecies of Lepus tolai, namely, Lepus tolai lehmanni and Lepus tolai centrasiaticus. Despite similar external morphological characters, hares in the southwest Pamir Plateau and its surroundings can be distinguished from L. tolai by differences in skull morphology and genetic divergence and were, therefore, considered a subspecies of Lepus tibetanus, Lepus tibetanus pamirensis. Furthermore, we found that hybridization and introgression occurred between sympatric or parapatric hares, especially between L. yarkandensis and L. tibetanus pamirensis, L. yarkandensis and L. tolai centrasiaticus, and L. tolai lehmanni and L. timidus.
Development and delivery of justice, equity, diversity, inclusion, and anti-oppression concepts in entry-level health professional education: a scoping review protocol
Authors: Coulter Emma , McQueen Conner , Abu-Jurji Zeina , Chan-Emery Isabelle , Rukavina Mark , Solecki Rachel , Wojkowski Sarah , Dhir Jasdeep 
Published: January 2024

Objective:
The objective of this scoping review is to identify the frameworks, guidelines, and models used to develop and deliver justice, equity, diversity, inclusion (JEDI), and anti-oppression (AO) principles in mandatory, entry-level health care professional program curricula (EHCPPC). A secondary objective will be to examine how these frameworks, guidelines, and models are used.

Introduction:
Health inequities are perpetuated globally, as observed by the suboptimal quality of care and health outcomes among equity-deserving groups. An understanding of JEDI and AO concepts is necessary in health care settings to promote culturally safe and high-quality care; however, entry-level health care programs may lack adequate integration of content and/or delivery of these principles. This scoping review will summarize the international literature on frameworks, guidelines, and models used to develop and deliver JEDI and AO concepts in EHCPPC.

Inclusion criteria:
This review will consider articles that discuss frameworks, models, or guidelines included in EHCPPC that guide the development and/or delivery of JEDI and AO principles in any country. Studies will be considered if they were published from 2015 to the present and are in English. All study designs will be considered for inclusion.

Methods:
This review will be conducted in accordance with the JBI methodology for scoping reviews. A search of MEDLINE (Ovid), Embase (Ovid), and CINAHL (EBSCOhost) will be conducted. Two or more independent reviewers will assess titles and abstracts, screen full-text studies, and extract data from included studies. Data from the included studies will be collated into tables or figures and described in a narrative summary.

Review registration:
Open Science Framework osf.io/ewqf8
Effectiveness of transoral robotic surgery for recurrent head and neck cancers: a systematic review protocol
Authors: Goel Sahil , Gunasekera Delu , Krishnan Giri , Lizarondo Lucylynn , Foreman Andrew 
Published: January 2024

Objective:
The objective of this systematic review is to evaluate the best available evidence regarding effectiveness of transoral robotic surgery in patients with recurrent head and neck cancers.

Introduction:
Transoral robotic surgery is now an established modality of treatment for primary head and neck cancer, showing good swallowing outcomes and quality of life for patients post-treatment. In patients with recurrent disease, conventional open surgery is often used, which prolongs recovery time and necessitates tissue disruption to gain access to the tumor site. Transoral robotic surgery is an emerging technique in this field as a minimally invasive approach to resection.

Inclusion criteria:
The review will include experimental or observational studies that investigated the use of transoral robotic surgery in adults (aged 18 years or older) with recurrent head and neck cancers for oncological, functional, and survival outcomes.

Methods:
Three databases will be searched for evidence: PubMed, Embase, and Scopus. Search terms for each database will include transoral robotic surgery, recurrent, salvage, and head and neck cancers. Reference lists of included articles will be searched for further evidence. Critical appraisal will be conducted by 2 independent reviewers using the JBI critical appraisal tools for quantitative studies. Data will be extracted by the same reviewers. Where appropriate, meta-analysis will be conducted for all outcomes.

Review registration:
PROSPERO CRD42023404613