bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graduate and postgraduate educational challenges during the COVID-19 pandemic period: its impact and innovations—a scoping review
Authors: Shoaib Muhammad Harris , Sikandar Muhammad , Yousuf Rabia Ismail , Parkash Monica , Kazmi Syed Jamil Hassan , Ahmed Farrukh Rafiq , Ahmed Kamran , Saleem Muhammad Talha , Zaidi Syeda Hina 
Published: October 2023

Abstract
Background
The coronavirus disease 2019 (COVID-19) pandemic has transformed the global view of education, including graduate and postgraduate education making the development of an alternative approach in times of social isolation an academic imperative. The present review aims to investigate the challenges experienced among undergraduate and postgraduate education and the strategies adopted to address these challenges during the pandemic.

Method
The preferred reporting items for the systematic review and meta-analyses extension for Scoping Reviews (PRISMA-ScR) were followed. The aim was to include journal articles published in the English language that discussed the influence of the pandemic on educational processes and applied innovative approaches as a solution to educational challenges. From January to August 2020, PubMed, EMBASE, and Google Scholar were searched for articles, yielding 10,019 articles. Two groups of authors examined the retrieved articles separately to avoid any risk of bias. The title and abstract of the articles were used for scrutiny, followed by full-text screening based on the established inclusion and exclusion criteria. The facts and findings of the studies were also discussed based on per capita income, literacy rate, and Internet accessibility.

Results
Thirty of the obtained articles were included in the study. The selected articles were from North and South/Latin America, Asia & Pacific, South Africa, and Europe regions. Nineteen of the selected articles dealt with undergraduate education, ten with postgraduate, and one with both groups. The affordability of digital devices and the availability of Internet services were the major challenges for low- and middle-income economies. The ZOOM platform has been adopted by more than 90% of the education systems.

Conclusion
Means of communication, including visual media, digitized content, and other web-based platforms, have been recognized as efficient learning and training tools, but have not been fully accessible for mass application and use due to the lack of availability of resources, their cost, and insufficient training among the users. In light of this review, it is suggested that harmonized and collaborative efforts should be made to develop cost-effective and user-friendly tools to overcome the current challenges and prevent future educational crises.

Systemic review registration
The review was not registered.
The PRISMATIC project: protocol for a research programme on novel methods to improve reporting and peer review of systematic reviews of health evidence
Authors: Page Matthew J. , Moher David , Brennan Sue , McKenzie Joanne E. 
Published: October 2023

Abstract
Background
Incomplete reporting about what systematic reviewers did and what they found prevents users of the report from being able to fully interpret the findings and understand the limitations of the underlying evidence. Reporting guidelines such as the PRISMA statement and its extensions are designed to improve reporting. However, there are important inconsistencies across the various PRISMA reporting guidelines, which causes confusion and misinterpretation. Coupled with this, users might need to consult multiple guidelines to gain a full understanding of the guidance. Furthermore, the current passive strategy of implementing PRISMA has not fully brought about needed improvements in the completeness of systematic review reporting.

Methods
The PRISMATIC (‘PRISMA, Technology, and Implementation to enhance reporting Completeness’) project aims to use novel methods to enable more efficient and effective translation of PRISMA reporting guidelines into practice. We will establish a working group who will develop a unified PRISMA statement that harmonises content across the main PRISMA guideline and several of its extensions. We will then develop a web application that generates a reporting template and checklist customised to the characteristics and methods of a systematic review (‘PRISMA-Web app’) and conduct a randomised trial to evaluate its impact on authors’ reporting. We will also develop a web application that helps peer reviewers appraise systematic review manuscripts (‘PRISMA-Peer app’) and conduct a diagnostic accuracy study to evaluate its impact on peer reviewers’ detection of incomplete reporting.

Discussion
We anticipate the novel guidance and web-based apps developed throughout the project will substantively enhance the completeness of reporting of systematic reviews of health evidence, ultimately benefiting users who rely on systematic reviews to inform health care decision-making.
The risk and outcome of malignant brain edema in post-mechanical thrombectomy: acute ischemic stroke by anterior circulation occlusion
Authors: Zhang Luojin , Li Jinze , Yang Benqiang , Li Wei , Wang Xinrui , Zou Mingyu , Song Hongyan , Shi Lin , Duan Yang 
Published: October 2023

Abstract
Background and purpose
Malignant brain edema (MBE) occurring after mechanical thrombectomy (MT) in acute ischemic stroke (AIS) could lead to severe disability and mortality. We aimed to investigate the incidence, predictors, and clinical outcomes of MBE in patients with AIS after MT.

Methods
The clinical and imaging data of 155 patients with AIS of anterior circulation after MT were studied. Standard non-contrast CT was used to evaluate baseline imaging characteristics at admission. Clinical outcomes were measured using the 90-day modified Rankin Scale (mRS) score. Based on the follow-up CT scans performed within 72 h after MT, the patients were classified into MBE and non-MBE group. MBE was defined as a midline shift of ≥ 5 mm with signs of local brain swelling. Univariate and multivariate regression analyses were used to analyze the relationship between MBE and clinical outcomes and identify the predictors that correlate with MBE.

Results
MBE was observed in 19.4% of the patients who underwent MT and was associated with a lower rate of favorable 90-day clinical outcomes. Significant differences were observed in both MBE and non-MBE groups: baseline Alberta Stroke Program Early CT (ASPECT) score, hyperdense middle cerebral artery sign (HMCAS), baseline signs of early infarct, angiographic favorable collaterals, number of retrieval attempts, and revascularization rate. Multivariate analysis indicated that low baseline ASPECT score, absent HMCAS, angiographic poor collaterals, more retrieval attempt count, and poor revascularization independently influenced the occurrence of MBE in AIS patients with anterior circulation after MT.

Conclusion
MBE was associated with a lower rate of favorable 90-day clinical outcomes. Low baseline ASPECT score, absent HMCAS, angiographic poor collaterals, more retrieval attempt count and poor revascularization were independently associated with MBE after MT.
Conditional knockout of PDK1 in osteoclasts suppressed osteoclastogenesis and ameliorated prostate cancer-induced osteolysis in murine model
Authors: Zhang Yanan , Nong Haibin , Bai Yiguang , Zhou Quan , Zhang Qiong , Liu Mingfu , Liu Pan , Zeng Gaofeng , Zong Shaohui 
Published: October 2023

Abstract
Background
The development and maintenance of normal bone tissue is maintained by balanced communication between osteoblasts and osteoclasts. The invasion of cancer cells disrupts this balance, leading to osteolysis. As the only bone resorbing cells in vivo, osteoclasts play important roles in cancer-induced osteolysis. However, the role of 3-phosphoinositide-dependent protein kinase-1 (PDK1) in osteoclast resorption remains unclear.

Methods
In our study, we used a receptor activator of nuclear factor-kappa B (RANK) promoter‐driven Cre‐LoxP system to conditionally delete the PDK1 gene in osteoclasts in mice. We observed the effect of osteoclast‐specific knockout of PDK1 on prostate cancer-induced osteolysis. Bone marrow-derived macrophage cells (BMMs) were extracted and induced to differentiate osteoclasts in vitro to explore the role of PDK1 in osteoclasts.

Results
In this study, we found that PDK1 conditional knockout (cKO) mice exhibited smaller body sizes when compared to the wild-type (WT) mice. Moreover, deletion of PDK1 in osteoclasts ameliorated osteolysis and rPDK1educed bone resorption markers in the murine model of prostate cancer-induced osteolysis. In vivo, we discovered that osteoclast‐specific knockout of suppressed RANKL-induced osteoclastogenesis, bone resorption function, and osteoclast-specific gene expression (Ctsk, TRAP, MMP-9, NFATc1). Western blot analyses of RANKL-induced signaling pathways showed that conditional knockout of PDK1 in osteoclasts inhibited the early nuclear factor κB (NF-κB) activation, which consequently suppressed the downstream induction of NFATc1.

Conclusion
These findings demonstrated that PDK1 performs an important role in osteoclastogenesis and prostate cancer-induced osteolysis by modulating the PDK1/AKT/NF-κB signaling pathway.
Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
Authors: Zhong Lishan , Wu Yanting , Huang Chen , Liu Kaisheng , Ye Cui-fang , Ren Zhe , Wang Yifei 
Published: October 2023

Abstract
Background
AT-533 is a novel heat shock protein 90 inhibitor that exerting anti-inflammatory, antiviral, and antitumor efficacy. Furthermore, the gel made of AT-533 as raw material named AT-533 gel has the function of repairing keratitis and dermatitis caused by herpes virus infection. However, the acute safety evaluation of AT-533 and AT-533 gel has not been conducted.

Methods and results
Herein, we performed acute toxicological studies of AT-533 and AT-533 gel in Sprague-Dawley rats. Fifteen-day acute toxicity study of AT-533 was conducted in both male and female Sprague-Dawley rats at doses of 5, 50, 250 and 500 mg/kg and AT-533 gel at 5 g/kg in the study. During experiment, food consumption and mortality were observed and body weight, hematology, serum biochemistry and histopathological assessment of rats were carried out. No abnormal changes were observed in rats percutaneously treated with AT-533 at 5 mg/kg and 50 mg/kg and AT-533 gel. However, loss of appetite and body weight, adverse reactions, toxicologically relevant alterations in hematology and biochemistry were found in rats percutaneously treated with AT-533 at 250 mg/kg and 500 mg/kg during 15-day acute dermic toxicity study.

Conclusions
The aforementioned results suggested that the LD50 of AT-533 is 228.382 mg/kg and the LD50 of AT-533 gel is greater than 5 g/kg. These findings indicated that AT-533 is non-toxic in rats when the dose less than 50 mg/kg and AT-533 gel can be considered a gel with no toxicity at doses less than 5 g/kg.
An intelligent vocabulary size measurement method for second language learner
Authors: Xia Tian , Chen Xuemin , Parsaei Hamid R. , Qiu Feng 
Published: October 2023

AbstractThis paper presents a new method for accurately measuring the vocabulary size of second language (L2) learners. Traditional vocabulary size tests (VSTs) are limited in capturing a tester’s vocabulary and are often population-specific. To overcome these issues, we propose an intelligent vocabulary size measurement method that utilizes massive robot testers. They are equipped with randomized and word-frequency-based vocabularies to simulate L2 learners’ variant vocabularies. An intelligent vocabulary size test (IVST) is developed to precisely measure vocabulary size for any population. The robot testers “take” the IVST, which dynamically generates quizzes with varying levels of difficulty adapted to the estimated tester’s vocabulary size in real-time using an artificial neural network (ANN) through iterative learning. The effectiveness of the IVST is factually verified by their visible vocabularies. Additionally, we apply a long short-term memory (LSTM) model to further enhance the method’s performance. The proposed method has demonstrated high reliability and effectiveness, achieving accuracies of 98.47% for the IVST and 99.87% for the IVST with LSTM. This novel approach provides a more precise and reliable method for measuring vocabulary size in L2 learners compared to traditional VSTs, offering potential benefits to language learners and educators.
Specific types of femoral head fractures: be alert for pre‐, intra‐, and post‐operative ipsilateral femoral neck fractures following fracture‐dislocation of the femoral head
Authors: Wu Shenghui , Mei Jiong 
Published: October 2023

AbstractPurposeIpsilateral femoral head and neck fractures (iFHNFs) are rare types of fractures that confer extremely poor prognosis among femoral head fractures (FHFs). Owing to the rarity of FHFs, it is challenging to diagnose iFHNFs. In addition, the clinical features of iFHNF have not yet been comprehensively elucidated. Therefore, this retrospective study aimed to summarize and analyze the clinical characteristics of iFHNF using a clinical diagnostic simulation based on a prospectively maintained database.MethodsClinical data of consecutive patients with FHFs, including gender, age, injury side, and associated injuries, were collected and analyzed from a prospectively maintained orthopedic database at a large level‐I trauma center for a clinical diagnostic simulation. Patients were stratified according to the presence or absence of iFHNF. Moreover, propensity score matching (PSM) was used to create 1:1 age‐ and gender‐matched couples. Lastly, clinical factors were compared and identified between the two groups before and after matching.ResultsA total of 218 FHF patients were included. Fifteen patients were diagnosed with ipsilateral femoral neck fractures (iFNFs), including preoperative, intraoperative, and postoperative types. There were 177 male and 41 female patients, with a mean age of 40.0 ± 16.5 years. The incidence of two factors, namely acetabular fracture and posterior hip dislocation, were significantly different between the two groups (P < 0.05). Following PSM, 15 pairs of patients were generated. Comparisons revealed that the incidence of posterior hip dislocation was significantly different between the two groups (P < 0.05).ConclusionsThere were three types of iFHNFs. In the context of FHFs, posterior hip dislocation was associated with iFNFs. Thus, surgeons should remain vigilant, not only intraoperatively but also postoperatively, for iFNFs following FHF and concomitant posterior hip dislocation.Level of EvidenceDiagnostic level IV
Usability assessment of the MoliCare absorbent continence products by nursing specialists
Authors: Sanaeifar Niuosha , Vechter Olga , Limam Deniz , Kesselmeier Rüdiger , Maurer Thomas 
Published: October 2023

Background: Incontinence is a common disorder among older adults with a higher prevalence in nursing home settings than in community dwellings. There is a wide variety of absorbent continence products on the market used to manage continence. Aim: The study aimed to investigate the experience of caregivers of residents with incontinence in care home settings using the new MoliCare Premium Form design and to compare some of the product features with the previous design. Method: A questionnaire focusing on the key performance characteristics of the product was developed and administered to 74 nurses in Germany to obtain their opinions on the use of MoliCare Premium Form products. Findings: More than 90% of respondents rated each key performance aspect of the new product design as ‘good’ and ‘OK’. More than 60% of the caregivers found the new product design to be better performing and 93% preferred the new design to the previous version. Conclusion: The newly redesigned continence pad performed very well on each of the individual performance features, indicating the high quality and optimised design of the product. The new design was found to be suitable and effective for individuals with incontinence.
Clinician perspectives on nonoperative management of hip fractures during COVID-19
Authors: Xiang Lucille , Singh Mriganka , McNicoll Lynn , Moppett Iain K. 
Published: October 2023

AimsTo identify factors influencing clinicians’ decisions to undertake a nonoperative hip fracture management approach among older people, and to determine whether there is global heterogeneity regarding these factors between clinicians from high-income countries (HIC) and low- and middle-income countries (LMIC).MethodsA SurveyMonkey questionnaire was electronically distributed to clinicians around the world through the Fragility Fracture Network (FFN)’s Perioperative Special Interest Group and clinicians’ personal networks between 24 May and 25 July 2021. Analyses were performed using Excel and STATA v16.0. Between-group differences were determined using independent-samples t-tests and chi-squared tests.ResultsA total of 406 respondents from 51 countries answered the questionnaire, of whom 225 came from HIC and 180 from LMIC. Clinicians from HIC reported a greater median and mean estimated proportion of admitted patients with hip fracture undergoing surgery (median 96% (interquartile range (IQR) 95% to 99%); mean 94% (SD 8%)) than those from LMIC (median 85% (IQR 75% to 95%); mean 81% (SD 16%); p < 0.001). Global heterogeneity seems to exist regarding factors such as anticipated life expectancy, insufficient resources, ability to pay, treatment costs, and perception of risk in hip fracture management decision-making.ConclusionThis study represents the first international sampling of clinician perspectives regarding nonoperative hip fracture management. Several factors seemed to influence the clinician decision-making process. Further research is needed to inform the development of best practice guidelines to improve decision-making and the quality of hip fracture care among older people.Cite this article: Bone Jt Open 2023;4(10):766–775.
Structural congenital anomalies in resource limited setting, 2023: A systematic review and meta-analysis
Authors: Geda Yohannes Fikadu , Lamiso Yirgalem Yosef , Berhe Tamirat Melis , Mohammed Seid Jemal , Chibsa Samuel Ejeta , Adeba Tadesse Sahle , Mossa Kenzudin Assfa , Abeje Seblework , Gesese Molalegn Mesele 
Published: October 2023

Background
A number of studies have looked at neonatal structural birth defects. However, there is no study with a comprehensive review of structural anomalies. Therefor we aimed to verify the best available articles to pool possible risk factors of structural congenital anomalies in resource limited settings.

Setting
Genuine search of the research articles was done via PubMed, Scopes, Cochrane library, the Web of Science; free Google database search engines, Google Scholar, and Science Direct databases. Published and unpublished articles were searched and screened for inclusion in the final analysis and Studies without sound methodologies, and review and meta-analysis were not included in this analysis.

Participants
This review analyzed data from 95,755 women who have birthed from as reported by primary studies. Ten articles were included in this systematic review and meta-analysis. Articles which have no full information important for the analysis and case reports were excluded from the study.

Results
The overall pooled effect estimate of structural congenital anomalies was 5.50 [4.88–6.12]. In this systematic review and meta-analysis maternal illness effect estimate (EI) with odds ratio (OR) = 4.93 (95%CI 1.02–8.85), unidentified drug use OR = 2.83 (95%CI 1.19–4.46), birth weight OR = 4.20 (95%CI 2.12–6.28), chewing chat OR = 3.73 (95%CI 1.20–6.30), chemical exposure OR = 4.27 (95%CI 1.19–8.44) and taking folic acid tablet during pregnancy OR = 6.01 (95%CI 2.87–14.89) were statistically significant in this meta-regression.

Conclusions
The overall pooled effect estimate of structural congenital anomalies in a resource limited setting was high compared to better resource countries. On the Meta-regression maternal illness, unidentified drug use, birth weight, chewing chat, chemical exposure and never using folic acid were found to be statistically significant variables Preconception care and adequate intake of folic acid before and during early pregnancy should be advised.
The Burden of Disease due to COVID-19 (BoCO-19): A study protocol for a secondary analysis of surveillance data in Southern and Eastern Europe, and Central Asia
Authors: Cawley Caoimhe , Gabrani Jonila , Stevanović Aleksandar , Aidaraliev Rakhat , Çakmak Barsbay Mehtap , Cilovic Lagarija Seila , Davletov Kairat , Djamangulova Tolkun , Glushkova Natalya , an der Heiden Matthias , Kaçaniku-Gunga Pranvera , Kereselidze Maia , Kryeziu Besfort , Lkhagvasuren Khorolsuren , Mehdiyev Samir , Oharova Dariia , Sadikkhodjayeva Diloram , Santric Milicevic Milena , Stanisic Milica , Stojisavljevic Stela , Tecirli Gulcan , Terzic Natasa , Wengler Annelene , Rommel Alexander ,   for the BoCO-19 Study Group
Published: October 2023

Introduction
The COVID-19 pandemic has had an extensive impact on public health worldwide. However, in many countries burden of disease indicators for COVID-19 have not yet been calculated or used for monitoring. The present study protocol describes an approach developed in the project “The Burden of Disease due to COVID-19. Towards a harmonization of population health metrics for the surveillance of dynamic outbreaks” (BoCO-19). The process of data collection and aggregation across 14 different countries and sub-national regions in Southern and Eastern Europe and Central Asia is described, as well as the methodological approaches used.

Materials and methods
The study implemented in BoCO-19 is a secondary data analysis, using information from national surveillance systems as part of mandatory reporting on notifiable diseases. A customized data collection template is used to gather aggregated data on population size as well as COVID-19 cases and deaths. Years of life lost (YLL), as one component of the number of Disability Adjusted Life Years (DALY), are calculated as described in a recently proposed COVID-19 disease model (the ‘Burden-EU’ model) for the calculation of DALY. All-cause mortality data are collected for excess mortality sensitivity analyses. For the calculation of Years lived with disability (YLD), the Burden-EU model is adapted based on recent evidence. Because Covid-19 cases vary in terms of disease severity, the possibility and suitability of applying a uniform severity distribution of cases across all countries and sub-national regions will be explored. An approach recently developed for the Global Burden of Disease Study, that considers post-acute consequences of COVID-19, is likely to be adopted. Findings will be compared to explore the quality and usability of the existing data, to identify trends across age-groups and sexes and to formulate recommendations concerning potential improvements in data availability and quality.

Discussion
BoCO-19 serves as a collaborative platform in order to build international capacity for the calculation of burden of disease indicators, and to support national experts in the analysis and interpretation of country-specific data, including their strengths and weaknesses. Challenges include inherent differences in data collection and reporting systems between countries, as well as assumptions that have to be made during the calculation process.