bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico study of inhibition activity of boceprevir drug against 2019-nCoV main protease
Authors: Tiwari Gargi , Chauhan Madan Singh , Sharma Dipendra 
Published: December 2023

Abstract
Boceprevir drug is a ketoamide serine protease inhibitor with a linear peptidomimetic structure that exhibits inhibition activity against 2019-nCoV main protease. This paper reports electronic properties of boceprevir and its molecular docking as well as molecular dynamics simulation analysis with protein receptor. For this, the equilibrium structure of boceprevir has been obtained by DFT at B3LYP and ωB97XD levels with 6-311+G(d,p) basis set in gas and water mediums. HOMO–LUMO and absorption spectrum analysis have been used to evaluate the boceprevir’s toxicity and photosensitivity, respectively. Molecular docking simulation has been performed to test the binding affinity of boceprevir with 2019-nCoV MPRO; which rendered a variety of desirable binding locations between the ligand and target protein’s residue positions. The optimum binding location has been considered for molecular dynamics simulation. The findings have been addressed to clarify the boceprevir drug efficacy against the 2019-nCoV MPRO.
Neolithic Flintworking of the Samborzec-Opatów Group in Lesser Poland in the Light of Settlement Materials from Tonie 9 Site, Kraków Commune
Authors: Wąs Marcin 
Published: December 2023

The article presents flint materials obtained from settlement site of Samborzec-Opatów group from the Tonie 9 site in Lesser Poland. The flintworking of this unit is still poorly recognized. In the literature, special attention has mainly been paid to ceramic materials, especially in studies on the genesis of this group and its relations with other taxonomic units of the Neolithic in Lesser Poland (especially with the Malice culture and later groups of the Lendziel). Therefore, it is worth introducing the specificity of Samborzec-Opatów flintworking, especially since the recently arrived inventory from the Tonie 9 site is quite numerous and relatively homogeneous. Therefore, the main goal is to present materials that can be used for further studies, e.g. those of a comparative nature.
The filament winding method’s finishing process impact on high-fidelity specimens: homogenity of density, fiber volume fraction, outer surface roughness and tensile strength
Authors: Purnomo Herry , Soemardi Tresna Priyana , D.S. Budiono Hendri , Wibowo Heri Budi , Ibadi Mahfud 
Published: December 2023

Filament winding is a widely used method for producing tubes and pressure vessels from composite materials. However, overlapping of fibers during the winding process can lead to rough surface and increased voids in the finished product. To improve the quality of CFRP materials produced through filament winding, the structure is cured either at room temperature or in an oven with a controlled heat profile, depending on the type of resin used. Various finishing techniques, including shrink tape, compression molding, and vacuum compression molding, have been attempted to improve the quality of the specimen. Among these techniques, vacuum compression molding has been found to deliver the best results in terms of surface roughness, with average roughness (Ra) values of 0.35 μm in the fiber direction and 0.61 μm in the transverse direction. This level of roughness is comparable to that achieved through milling machine manufacturing. Moreover, this technique ensures uniformity in fiber composition and volume fraction, achieving a homogeneous density of 1364.49 kg/m3 and the highest fiber volume fraction of 63 %. As a result, remarkable mechanical attributes, such as a tensile strength of 926.07 MPa and a stiffness of 21.35 GPa, can be obtained. In addition, by utilizing various finishing techniques, the tensile strength of these properties can be increased by up to 80 %. CFRP is a versatile material with unique characteristics, and selecting appropriate finishing techniques such as vacuum compression molding can significantly enhance its overall quality and mechanical properties. However, one drawback of the filament winding method is the poor outer surface finish which can be improved by vacuum compression molding
Development of buckwheat groats production technology using plasma-chemically activated aqueous solutions
Authors: Kovalova Olena , Vasylieva Natalia , Haliasnyi Ivan , Gavrish Tatiana , Dikhtyar Aliona , Andrieieva Svitlana , Didukh Nataliia , Balandina Iryna , Obolentseva Larysa , Hirenko Nataliia 
Published: December 2023

The result of the conducted research is the development of a technology for the production of buckwheat groats using plasma-chemically activated aqueous solutions. The research object was buckwheat grain. An urgent technological problem is the preservation of biologically valuable components of buckwheat during technological operations and optimization of the existing technology for the production of buckwheat groats. The expediency of using plasma-chemically activated aqueous solutions as an intensifier of the technological process of production of buckwheat groats and an effective groats disinfectant has been experimentally proven. It is shown that the use of plasma-chemical activation of technological solutions allows reducing the temperature and accelerating the course of hydrothermal treatment of buckwheat grain. The composition of buckwheat grain as a raw material was analyzed. The obtained buckwheat groats were studied separately. A reduction in tempering time from 6–10 to 2 h and a decrease in the optimal moistening temperature from 60 to 40 °C were recorded. This allows preserving a number of biologically important components in buckwheat grain. The groats yield increases from 68 to 74 %, i.e. by 1.9–6.0 %. The preservation of the maximum number of amino acids is observed, namely, 7.7 % more than in the control. That is, only 2 % is lost during technological processing, instead of 9.7 % in the control sample. The vitamin composition also remains stable and almost does not decrease in terms of B1, B2, B3, B4, B5, B6, K, E, PP, R. In addition, plasma-chemically activated solutions qualitatively disinfect grain raw materials during processing, which has a positive effect on further storage of buckwheat groats.
The technology can be applied in the industrial production of high-quality buckwheat groats. The developed technology will receive special attention in the production of ecologically clean cereal products that are not contaminated with pathogenic microflora
Determining features in the wear resistance characteristics of tribocompounds with a textured hole surface under conditions of boundary friction
Authors: Marchuk Volodymyr , Kindrachuk Myroslav , Harmash Oleh , Kharchenko Volodymyr 
Published: December 2023

The influence of surface texture in the form of pits on the wear resistance of tribocompounds under conditions of limit friction was investigated. At the first stage of research, the mechanism of lubricant behavior between the contacting surfaces and inside the holes was modeled. The limiting condition of the rotation frequency of the sample (n>27) was established, under which a drop of lubricant "leaves" the hole in the upper position of the sample and remains in the space between the sample and the surface of the counterbody, ensuring the regeneration of the boundary lubricating film on the surface of the tribocontact when it is destroyed. When the rotation frequency of the sample is reduced (n<27), the lubricant droplet remains in the hole and does not affect the processes of the boundary lubricant film. At the second stage, experimental studies of tribocombinations with a textured hole surface under conditions of extreme friction were carried out. It was established that the high wear resistance of the textured hole surfaces is provided by the high protective effect of the texture, as well as the high efficiency of the marginal lubricating film. It has been proven that the strengthening of the surface texture by the method of ion-plasma thermocyclic nitriding additionally increases the wear resistance by 1.7 times due to the high protective effect of surface nitrided layers and their high hardness (up to 9500 MPa). This strengthens the effect of inhibiting the occurrence of defects in the surface layers of tribocontact, ensures a high rate of wetting of the places of actual contact of triboconnections, and speeds up the process of regeneration of the boundary lubricating film. Research results can be used to modify the surface layer of heavily loaded parts operating under extreme operating conditions with limited supply of lubricant under various types of friction and wear
Increasing the accuracy of electrostatic fields strength measurement by using an improved differential transimpedance amplifier circuit
Authors: Povcshenko Oleksandr , Bazhenov Viktor , Pazdrii Olha , Bohdan Halyna 
Published: December 2023

An electrostatic field mill (EFM) is widely used to measure the strength of electrostatic fields, the main drawback of which is the occurrence of large measurement errors (up to 15 % in the range from 0 to 1 kV/m).
This paper examines the aspects of using transimpedance amplifiers (TIAs) for the tasks of converting the current received from the EFM sensor into voltage, which will make it possible to reduce the instrumental error and ensure the linearity of the atmospheric electrostatic field strength measurement. In the general case, for the functional circuits of the electrostatic field mill, which include a differential transimpedance amplifier, there is the use of two TIA circuits, which are connected in parallel. Despite the simplicity of implementation, such a configuration contains a number of disadvantages and is not optimal. In the paper, a comparative analysis of a typical circuit of a differential TIA and a circuit of an ungrounded differential transimpedance amplifier with zero voltage drop proposed by the authors is carried out.
As a result of the analysis, it was established that the designed authentic circuit of the ungrounded differential transimpedance amplifier with zero voltage drop has better parameters of linearity and interference resistance, in contrast to the generally accepted one. The value of the signal-to-noise ratio for the proposed scheme improved by 42 % on average compared to the typical one. The main difference of the proposed scheme is that the stability of the amplification factor is ensured, the influence of the bias parameters of the operational amplifier is leveled, and the overall noise level is reduced. The use of the designed scheme of an ungrounded differential transimpedance amplifier with zero voltage drop could make it possible to increase the accuracy of the measurement of the electrostatic field strength
Exploring challenges and opportunities in detecting emerging drug trends: A socio-technical analysis of the Canadian context
Authors: Bouchouar Etran , Levine Marissa J. , Ileka-Priouzeau Samuel , Dave Sailly , Fu Allan , Salemi Jason L. 
Published: December 2023

Abstract
Objectives
This study aimed to apply a systems thinking approach to explore factors influencing the detection of emerging drug trends in Canada’s provinces and territories to better understand how the local context can influence the design and performance of a pan-Canadian (i.e., national) substance use early warning system (EWS). This study also presents a set of actionable recommendations arising from the results.

Methodology and methods
Semi-structured interviews were conducted with 13 purposively recruited Medical Officers of Health and epidemiologists from across Canada working in the field of substance use. Thematic and social network analysis guided by the socio-technical systems framework were subsequently employed.

Results
Barriers and facilitators for detecting emerging drug trends in provinces and territories are a product of the collective linkages and interactions between social (objectives, people, culture), technical (tools, practices, infrastructure), and external environmental (financial, regulatory frameworks, stakeholders) factors. Shortcomings in several of these areas shaped the system’s behaviour and together contributed to fragmented operations that lacked strategic focus, poorly designed cross-sector partnerships, and unactionable information outputs. Participants’ experiences shaped perceptions of a national substance use EWS, with some voicing potential opportunities and others expressing doubts about its effectiveness.

Conclusion
This study highlights interconnected social, technical, and external environmental considerations for the design and implementation of a national substance use EWS in Canada. It also demonstrates the value of using the socio-technical systems framework to understand a complex public health surveillance issue and how it can be used to inform a path forward.
THE EFFECTS OF COMBINATION OF RADIOFREQUENCY AND PULSED MAGNETIC FIELD ON CAROTID ARTERIA ISCHEMIA AND REPERFUSION INDUCED BRAIN INJURY: A PRELIMINARY REPORT
Authors: TANER Rümeysa , AŞÇI Halil , UYSAL Dinçer , AŞCI Sanem , DOĞAN ÜNLÜ Melike , OĞUZOĞLU Ali Serdar , ÇÖMLEKÇİ Selçuk , ÖZMEN Özlem 
Published: December 2023

Objective
Cerebrovascular accident due to ischemia (IS)
mediated by atherosclerotic plaque in the brain
can trigger inflammation in the cerebral cortex,
hippocampus and cerebellum tissues. Radiofrequency
electromagnetic field (RF-EMF) and pulsed magnetic
field (PMF) applications can increase nitric oxide
formation from the vascular endothelial layer. The
aim of this preliminary study is to reduce the damage
caused by IS in different tissues of the brain by
magnetic field applications.
Material and Method
A total of 9 rats, one rat in each group; sham,
prophylactic RF, PMF, RF+PMF and therapeutic
RF-EMF, PMF, RF-EMF+PMF, prophylactic and
therapeutic RF-EMF+PMF and IS-only groups were
distinguished. In single or combined applications of
prophylactic/therapeutic RF-EMF and PMF groups,
rats were taken to the experimental unit for 30
minutes of magnetic field exposure before and after
30 minutes of carotid artery occlusion for IS purposes.
Histopathological hematoxylin-eosin staining in
brain tissue (cerebral cortex and hippocampus)
and cerebellum tissues taken after sacrification;
With immunohistochemical analysis, brain derived
neurotrophic factor (BDNF), tumor necrosis factoralpha
(TNF-α), mammalian target of rapamycin
(mTOR) and inducible nitric oxide synthase (iNOS)
expressions were examined.
Results
Histopathologically significant hyperemia, edema,
bleeding and neuronal degeneration were detected
in the IS group. Additionally, immunohistochemically,
an increase in TNF-α, mTOR, iNOS and a decrease
in BDNF staining were observed. Prophylactic and/or
therapeutic RF-EMF and/or PMF applications reversed
all these parameters. The greatest improvement
was observed in the Prophylactic+Therapeutic RFEMF+
PMF group.
Conclusion
As a result, the regression of IS-related inflammation in
both brain tissue parts and cerebellar tissues with RFEMF
and PMF is important in terms of the formation
of neurological deficits, the continuity of learning
and memory mechanisms, and the preservation of
balance functions.
Pengembangan Modul Pembelajaran Inventor Berbasis Contextual Teaching And Learning (CTL) Pada Mata Pelajaran Teknik Gambar Manufaktur di SMK Negeri 1 Singosari
Authors: Rohman Afif Fakhoor , Widiyanti Widiyanti , Suyetno Agus 
Published: December 2023

Abstrak: Penelitian pengembangan ini bertujuan untuk mengetahui efektivitas serta peningkatan kompetensi siswa pada mata pelajaran TGM dengan pengembangan modul Inventor berbasis Contextual Teaching And Learning (CTL) terhadap siswa kelas XI di SMK Negeri 1 Singosari. Hasil penelitian dan pengembangan menunjukkan, 1) hasil validasi ahli media 96.70%, validasi materi 96.70%, kelompok kecil 88.33%, kelompok besar 89.38%, sehingga layak dikembangkan. Serta dapat meningkatkan efektivitas belajar siswa diperolehnya nilai pada kelompok thitung > tTabel 6.000 > 2.776, dan kelompok besar thitung > tTabel = 12.880 > 2.05. 2) nilai rata-rata hasil belajar siswa di atas KKM sebesar 96.66% yang dapat meningkatkan kompetensi siswa. Kata kunci:. Pengembangan Bahan Ajar, Modul Inventor, Contextual Teaching And Learning
Penerapan Teaching Factory (Tefa) Sebagai Upaya Meningkatkan Mutu Lulusan Proli Teknik Kimia Industri SMK Negeri 2 Bangkalan
Authors: Hazizah Nur 
Published: December 2023

Abstrak: Penelitian ini untuk a) Pelaksanaan program pembelajaran teaching factory, b) Pembelajaran teaching factory berbasis unit produksi, c) Pelaksanaan pembelajaran teaching factory dalam meningkatkan semangat kewirausaha siswa. Metode penelitian yang digunakan adalah metode penelitian deskriptif. Penelitian ini berusaha menggambarkan atau melukiskan keadaan objek penelitian pada sekarang berdasarkan fakta-fakta yang tampak atau sebagaimana adanya tentang pelaksanaan pembelajaran teaching factory berbasis unit produksi untuk meningkatkan semangat kewirausahaan siswa di Program Keahlian Teknik Kimia Industri SMK N 2 Bangkalan Hasil penelitian menunjukkan bahwa: 1) Pelaksanaan pembelajaran teaching factory sudah sesuai dengan konsep dan element, perlengkapan dan peralatan sudah terpenuhi, aspek pemasaran belum maksimal 2) Pembelajaran teaching factory berbasis unit produksi bermanfaat sebagai pengalaman dan melatih jiwa kewirausahaan siswa. Kata kunci:. Teaching Factory, Teknik Kimia Industri, SMKN 2 Bangkalan
Through the eyes of Parkinson\'s: A narrative review of clinical spectrum and ophthalmological challenges in Parkinson’s disease
Authors: Doke Rohit , Sonawane Sonali , Thorat Vivek , Bhabad Sarika , Lamkhade Ganesh , Jadhav Sagar , Jain Ritesh , Bhagwat Ajay 
Published: December 2023

The ophthalmic non-motor dysfunctions are most common among individuals with Parkinson’s disease, manifesting both prior to motor symptoms and throughout the progression of the neurodegenerative condition. Detecting these impairments early on holds significant potential for disease identification, particularly in its nascent stages. Given the comprehensive nature of ocular involvement, encompassing both extraocular and intraocular elements of the visual system, a comprehensive evaluation stands to benefit patients. Considering the shared embryonic origin of the retina and central nervous system, exploring retinal changes in Parkinson's disease could yield insights applicable to the broader brain context. Consequently, identifying these manifestations could enhance medical assessments of Parkinson's disease and offer predictive value regarding its progression.The impact of these ophthalmological issues extends to the quality of life of Parkinson's disease patients, accentuating the importance of addressing them. This review presents a comprehensive overview of the primary visual impairments linked to Parkinson's disease, reflecting a substantial portion of the visual challenges encountered by affected individuals and for the overall well-being of those living with the condition.
Trabeculectomy with collagen implant for the treatment of glaucoma
Authors: Kadir Syeed Mehbub Ul , Maurya Rajendra P , Noman Shams Mohammad , Roy Tanima 
Published: December 2023

The goal is to assess the effectiveness and safety of trabeculectomy with collagen implants for glaucoma patients who cannot be managed medically. This research is a case series that intervenes without randomization and focuses on potential outcomes. The study consisted of 76 treated eyes of 76 patients with uncontrollable glaucoma. A thorough examination of the eyes was performed on all patients, and the results were documented. Each patient underwent conventional trabeculectomy surgery using the fornix-based approach. Additionally, a subconjunctival collagen implant known as Ologen was also utilized. We recorded preoperative data such as age, gender, best-corrected visual acuity, intraocular pressure, glaucoma type, and a few preoperative antiglaucoma medications. We recorded the intraocular pressure after surgery, the number of glaucoma medications given after surgery, and any complications that occurred during the postoperative period. Each patient was monitored for a minimum of six months. Before the operation, the average intraocular pressure (IOP) was 34.21 ± 12.5, and the patient took at least two IOP-lowering medications (average 2.3). The postoperative IOP was measured after three months and found to be 13.85±5.42mm Hg, with a p-value of 0.060. On average, the blood pressure decreased by 16.42±6.42 mmHg after six months, with a p-value of 0.056. After six months, it was observed that the medication significantly reduced 1.22 in intraocular pressure (P=&#60;0.001), leading to a notable decrease of 17.79 mmHg. The success rate stood at a commendable 97.36% at the three-month mark, but it reduced to an alarming 88.15% by the last visit. Within just one month after the operation, several complications arose, including three cases of hyphaema, one case of the shallow anterior chamber, and two cases of wound leak. All patients showed gradual improvement with conservative management. However, three of them developed cataracts within three months. For patients who have not responded to topical antiglaucoma medications, to manage intraocular pressure is a dependable and safe surgical procedure that offers an efficient treatment option.
Comparison of spherical equivalent determined by Sanders-Retzlaff-Kraff-II (SRK-II) formula with target post-operative final refraction in patients undergoing cataract surgery
Authors: Kabra Ruchi , Raol Krupali , Desai Hemaxi , Gajjar Riddhi , Panchal Deep , Maurya Rajendra P 
Published: December 2023

The most challenging subject in patient satisfaction after cataract surgery depends upon post-operative refractive outcomes. Accurately predicting post-operative refraction is necessary during the calculation of Intraocular lens (IOL) power. The Sanders-Retzlaff-Kraff (SRK) II formula is one of the few formulae being used for the calculation of IOL power. Our study is to compare the accuracy of the SRK-II formula with targeted final refraction of patients undergoing phacoemulsification. This study was performed on 102 eyes that underwent phacoemulsification. IOL power was calculated using the SRK-II formula. One and a half months after surgery, refraction was performed. Differences between actual post-operative refraction and predicted spherical equivalent was calculated and termed absolute refractive error. Paired t-test was used for comparing actual post-operative refraction and predicted spherical equivalent.The mean absolute error (MAE) of the SRK-II formula was 0.44 D (diopters) overall. The percentage of eyes within ±0.5 D of the predicted spherical equivalent was 81%. Patients having post-operative refractive error within ±1.0 D for short, average, and long axial length were 88% (P value 0.21), 92% (P value 0.0009), and 91% (P value 0.18) respectively.We found that the SRK-II formula was accurate and reliable for predicting the post-operative refractive error in eyes with normal axial lengths as the post-operative refraction is near emmetropia and is a good method for IOL power calculation with normal axial lengths.