bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВИЗНАЧЕННЯ РІВНІВ АДЕНОЗИНМОНОФОСФАТ-АКТИВОВАНОЇ ПРОТЕЇНКІНАЗИ ТА ХЕМЕРИНУ У ПАЦІЄНТІВ З ЦУРОВИМ ДІАБЕТОМ 2 ТИПУ ТА ПОДАГРИЧНИМ АРТРИТОМ ЯК ПРОГНОСТИЧНИХ МАРКЕРІВ ПОРУШЕННЯ ВУГЛЕВОДНОГО ОБМІНУ
Authors: Журавльова Лариса , Стоянова Юлія 
Published: December 2023

Актуальність. Цукровий діабет 2 типу (ЦД 2 типу) – багатофакторне епігенетичне захворювання, яке має широку поширеність у світі. Встановлено, що комбінація подагричного артриту (ПА) та ЦД 2 типу є досить розповсюдженою. У дослідженнях було встановлено, що гіперурикемія збільшує інсулінорезиствнтність та пригнічує ефекти інсуліну, що є патогенетичним шляхом розвитку ЦД 2 типу, тому вивчення біохімічних зв’язків між пуриновим та вуглеводними обмінами є необхідним. Для оцінки в якості маркерів, що відображають стан вуглеводного обміну у пацієнтів з ЦД 2 типу та ПА, були обрані аденозинмонофосфат-активована протеїнкіназа (AMPK) та хемерин.
Мета роботи: аналіз рівнів AMPK і хемерину та визначення їх кореляційних взаємозалежностей з показниками вуглеводного метаболізму у пацієнтів з цукровим діабетом 2 типу та подагричним артритом.
Матеріали та методи. У дослідженні приймали участь 100 пацієнтів обох статей, які були розподілені на 2 групи: 1 група – пацієнти із ПА та ЦД 2 типу, n=70; 2 група – пацієнти із моноперебігом ПА, n=30. Контрольна група – 20 відносно здорових осіб. Всім тематичним хворим оцінено рівні сироваткового хемерину, AMPK, глюкози крові натще, глікованого гемоглобіну, інсуліну за загальноприйнятими методиками; індекс HOMA-IR був розрахований математично. Для статистичного аналізу використовували коефіцієнт лінійної кореляції Пірсона (r) та дисперсійний аналіз.
Результати. Найнижчі рівні AMPK (8,56±4,01 нг/мл) отримані у пацієнтів 1 групи порівняно до 2 групи (21,93±4,87 нг/мл, p1,2<0,0001) та групи контролю (26,37±5,56 нг/мл p1,К<0,0001). Визначено більш високі рівні хемерину серед пацієнтів 1 групи (12,51±3,92 нг/мл) та 2 групи (9,86±2,66 нг/мл) відносно групи контролю (3,41±1,42 нг/мл, p<0,0001). При коморбідному поєднанні ЦД 2 типу та ПА були відзначені вірогідні кореляційній взаємозв’язки переважно середньої сили між показниками АМРК (зворотні), хемерину (прямі) та вуглеводного метаболізму серед обстежених хворих.
Висновки. Виявлені кореляційні зв’язки між AMPK, хемерином та показниками вуглеводного обміну дозволяють стверджувати, що вищевказані маркери грають патогенетичну роль та мають діагностично-прогностичну значущість відносно виявлення інсулінорезистентності у хворих на подагричний артрит та оцінки ступеню важкості цукрового діабету 2 типу у пацієнтів із коморбідною патологією.
Caminos entreverados: dos trayectorias intelectuales. Sobre Trilce Laske. Los caminos del éxito. Dos hombres de saber novohispanos (1683-1705)
Authors: Mejía Torres Karen Ivett 
Published: December 2023

Reseña crítica sobre un libro de historia intelectual publicado el año 2023 que aborda la trayectoria de dos clérigos jesuitas en Nueva España, principalmente sus estrategias de promoción.
Laske, Trilce (2023), Los caminos del éxito. Dos hombres de saber novohispanos (1683-1705), Lejona, Universidad del País Vasco/ EuskalHerriko Unibertsitatea, 236 pp., ISBN: 978-84-1319-542-1
Formulation Development and In-Vitro Evaluation of Transferosomal Gel of Mometasone Furoate
Authors: Begum Arshiya , Basha Syed Abdul Azeez , Mohammed Shahid , Begum Arjumand 
Published: December 2023

The main aim of the study is to formulate and evaluate transferosomal gel formulation for effective topical delivery of Mometasone furoate. The transferosomes was prepared using thin film hydration technique by various proportions of Soya phosphatidylcholine, tween 80. The drug was encapsulated into eight different Transferosomal formulations from F1-F8. The optimized formulation F4 showed small particle size (152.48 nm), entrapment efficiency % EE of 87.16%, zeta potential of -32mV, 0.252 PDI and % Cumulative Drug Release of (97.14%). SEM of optimized Transferosome appeared as spherical, well identified, Unilamellar vesicles. The optimized formulation of Transferosomes was further formulated to transferosomal gel with Carbopol-940 (0.2 to 0.8% w/w), HPMC k15 (0.2 to 0.8% w/w), Propylene glycol, Triethanolamine and Isopropyl alcohol. Among these, F4 formulation with Carbopol-940 0.8%w/w transferosomal gel is the optimized transferosomal gel and showed Spreadability value 0.229±0.01gm.cm/sec, pH value 5.8. The actual drug content of the Transferosomal gel was found to be 98.90%, which represents good content uniformity. The viscosity of optimized Transferosomal gel was found to 55417cps. The percentage drug release for Transferosomal gel was 98.22%. And the formulation was stable throughout the stability studies. This research suggests that Mometasone Furoate loaded transferosomal gel can be potentially used as a transdermal drug delivery system for effective topical delivery.
Keywords: Mometasone Furoate, Transfersomes, Soya phosphatidyl choline and Tween 80.
A Review on Hashimoto’s Thyroiditis
Authors: Geetha Karra , Sasanka G. , Pridvineel S. , Banu Meraj Unnisa , Rama Rao T. 
Published: December 2023

Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder first described by Japanese physician Haraku Hashimoto in 1912 characterized by lymphocytic infiltration of the thyroid parenchyma and is influenced by immune system instability. The onset of autoimmunity may be influenced by innate and acquired immune responses. Thyroid autoantibodies (TAbs) are the primary biochemical feature. Epidemiological studies show AITD (autoimmune thyroid disease) risk is higher in women and is age-related. Risk factors include high iodine consumption, selenium insufficiency, infectious disorders, and specific medications. Genetic predisposition and environmental factors also contribute to HT. Pregnancy and sex steroids play a role in the development of autoimmune thyroiditis, with older women being more susceptible. The immune system is modified during pregnancy, with progesterone playing a significant role. About 20% of postpartum thyroiditis patients eventually develop HT. The symptoms include dysphonia, dyspnea, and dysphagia, with primary hypothyroidism causing greater systemic symptoms. Diagnosis involves circulating thyroid-specific antibodies, ultrasound examination, increased thyroid stimulating hormone, and normal serum thyroid hormone levels. Ultrasonography is crucial for diagnosing Hashimoto's thyroiditis, distinguishing it from other thyroid disorders like Graves' disease (GD). The treatment comprises levothyroxine, which effectively lowers thyroid volume, as well as vitamin D deficiency and replacement. Autoimmune thyroiditis (AIT) surgery has traditionally been reserved for people who have discomfort or compressive symptoms from goitre or co-existing malignant thyroid nodules. Thyroidectomy has lately been advocated as a treatment option for decreasing TPOAbs, as the presence of such antibodies is linked to a worse quality of life even in euthyroid patients.
Keywords: Hashimoto’s thyroiditis (HT), Autoimmune thyroid disease (AITD), Autoimmune thyroiditis (AIT) Vitamin D , Levothyroxine
Revolutionizing Drug Delivery: Nicardipine Nanosuspension Formulation and In-Vitro Evaluation
Authors: Miskan Risha , Shahidulla S M , Sultana Sana 
Published: December 2023

Nicardipine hydrochloride, is a potent calcium channel blocker, is commonly used in the management of hypertension and angina. It is a BCS class II drug which has low aqueous solubility and high permeability. In the present study, an attempt was made to formulate and evaluate nanosuspension of Nicardipine hydrochloride using different stabilizers, namely Tween 80, PVP K30, Poloxamer 188 by using Nanoprecipitation method with the objective to improve solubility and enhance dissolution of Nicardipine hydrochloride. Prepared nanosuspensions were evaluated for drug-excipient compatibility, particle size, PDI (Polydispersity Index), Zeta potential, Drug content, Saturation solubility, In-vitro release study, Scanning electron microscopy (SEM). FTIR (Fourier Transform Infrared Spectroscopy) studies revealed the compatibility of the drug with excipients. Nanosuspension (F3), which had the lowest particle size and the highest % Drug Release, was selected as the optimum formulation. It showed the droplet size, PDI, ZP,% Drug content and %Drug release of 150.4 nm,0.243, -30.6 mV,95.52%,91.24%. Kinetic release profiles of the NS F3 revealed that it followed First order kinetics. This study showed the ability of nanosuspension system in improving the solubility and drug release of Nicardipine.
Keywords: Nicardipine, Nanosuspension, Solubility, % Drug Release, % Drug content, Scanning electron microscopy.
Innovative Nanosuspension Formulation for Prochlorperazine and In-vitro Evaluation
Authors: Sultana Sana , Mohammed Shahid , Miskan Risha 
Published: December 2023

Prochlorperazine is a dopamine antagonist and is used to control nausea and vomiting. It is a BCS class II drug which has low aqueous solubility and high permeability. The present study is aimed to formulate and evaluate prochlorperazine nanosuspension to improve solubility and enhance dissolution of Prochlorperazine with varying concentrations of stabilizers such as Tween 80, PVP K30, Poloxamer 188 by using nanoprecipitation method. The developed formulations were characterized for particle size and polydispersity index, total drug content, SEM, Zeta Potential and FTIR. The invitro drug release studies and invitro drug release kinetics were performed for all formulations. FTIR studies revealed that drug is compatible with the excipients. The particle size and poly dispersity index of optimized formulation was found to be 162nm and the zeta potential was found to be -30.2 mV and concluded that the system had sufficient stability. The invitro drug release was found within their acceptable ranges. The rate of dissolution of best batch was enhanced to 93.24 in 120min. Stability studies proved that nanosuspensions were more stable with no significant changes in particle size distribution. Thus the formulated nanosuspension of prochlorperazine offers a superior conventional dosage forms for drug release
Keywords: Prochlorperazine, Nanosuspension, Solubility, Dissolution
Phytochemical profile, acute oral toxicity, antioxidant, and antispasmodic effects of ethyl acetate and aqueous residual fractions of Diospyros mespiliformis Hochst. ex A. DC (Ebenaceae) leaves on isolated duodenum of rat
Authors: NITIEMA Mathieu , OUEDRAOGO Windingoudi Rimwagna Christian , BOLY Rainatou , OUEDRAOGO Pegdwendé Esther , MAMAN NOURA Oumarou , KABORÉ Boukaré , BÉLEM-KABRÉ Wendkouni Leila Marie Esther , TRAORÉ Tata Kadiatou , COMPAORÉ Souleymane , KOALA Moumouni , NÉBIÉ Bruno , OUOBA Abdel Magid Arsène , MAKAYA Makumbu Joseph , BELEMNABA Lazare , OUÉDRAOGO Sylvin 
Published: December 2023

Introduction: Diospyros mespiliformis Hochst. ex A. Rich (Ebenaceae) is a nutritional, artisanal and medicinal plant. It is used in alternative medicine in Burkina Faso for the treatment of conjunctivitis, menorrhagia, dysentery, and especially diarrhea. Aims: Our study aimed to evaluate the chemical profile, the antioxidant and anti-inflammatory activities, the safety of use, and the spasmolytic effects of the fractions obtained from the aqueous decoction of the leaves of Diospyros mespiliformis. Methods: Phytochemical screening by HPTLC and the determination of compounds of interest were carried out. The antioxidant activity was evaluated according to the ABTS, DPPH, FRAP, and LPO methods. The inhibitory activity of Phospholipase A2 and 15-lipoxygenase was evaluated. Acute oral toxicity was carried out on female mice (NMRI). The ex vivo spasmolytic effect of the fractions was tested on isolated rat duodenum using ACh and BaCl2 as contracting agents. Results: At the end of these tests, the fractions contain flavonoids, tannins, sterols, triterpenes, and saponosides. The content of total phenolics was respectively for the ethyl acetate fraction (EAF) and the residual aqueous fraction (RAF) 84.15±1.73 mg EAT/g and 89.67±2.35 mg EAT/g. That of flavonoids was respectively 45.91 ± 0.98 mg EQ/g and 10.46±0.28 mg EQ/g for the two fractions. The 50% inhibitory concentrations (IC50) of EAF for the ABTS, DPPH, and FRAP tests were 2.26±0.16 μg/mL, 22.34±7.23 μg/mL and 1136.25±0.90 mol EAA/g respectively, and an inhibition % of 43.80 ± 6.31% for LPO. For RAF, the IC50 were in the same range as EAF of 16.82±0.23 μg/mL, 18.58±2.91 μg/mL, 1138.4±1.27 mol EAA/g and an inhibition of 45.14±10.35% for LPO. The fractions had an inhibitory effect on phospholipase A2 compared to Betamethasone. Finally, the most active EAF caused a spasmolytic effect with Emax of 87.4±15.71% and 90.40±7.84%, respectively, during contractions induced by BaCl2 and ACh. Conclusion: Finally, this work provided scientific data and could justify the use of D. mespiliformis leaves in the treatment of diarrhea.
Keywords: Diospyros mespiliformis, Leaves, Antioxidants, Anti-inflammatory, Safety of use, Spasmolytic
Qualitative and Quantitative Analysis of Selected Antibiotics Used in Djibouti Hospitals
Authors: Fourreh Abdirahman Elmi , Abdoul-Latif Fatouma Mohamed , Mouti Chayma 
Published: December 2023

The analysis of drugs is a priority in public health, particularly antibiotics which develop resistance due, among other things, to bad dosages or poor-quality of the active substance. In this study, we evaluated eight antibiotics available in health centers in Djibouti through qualitative and quantitative analysis. The tests were based on high-purity reference products. In qualitative analysis by HPLC, only amoxicillin presented two impurity peaks. This observation is found in the dosage of this active ingredient with a value of 83 ±0.6 mg instead of the 500 mg indicated on the label. It will be necessary to diversify the sample’s provenance to seek the origin of this degradation.
Keywords: analysis; antibiotic; djibouti; HPLC; spectrophotometer; TLC
UV Spectrophotometric Method for Estimation of Voriconazole in Bulk Form
Authors: Priya NAGAM Santhi , Krishna P. Siva , Amani D. , Pujitha K. Sree , Tejasri K. , Babu Ch. Vinay , Reddy T. Seshu , Babu P. Srinivasa 
Published: December 2023

This study presents a validated UV spectrophotometric method for the precise estimation of voriconazole in bulk formulations. Voriconazole, an essential antifungal agent, demands accurate quantification for its pharmaceutical applications. The proposed method leverages the sensitivity of UV spectroscopy to determine voriconazole concentrations effectively.
The method's validation adheres to regulatory guidelines, ensuring reliability and accuracy. Spectrophotometric analysis was performed within a specific wavelength range, demonstrating linearity, precision, accuracy, and robustness across different concentrations of voriconazole.
Parameters such as specificity, sensitivity, and stability were evaluated to affirm the method's suitability for routine analysis.
The results indicate the method's efficacy in quantifying voriconazole in bulk and semi-solid forms with high precision and sensitivity. This validated UV spectrophotometric method presents a valuable tool for pharmaceutical analysis, facilitating quality control and assurance in voriconazole formulations.
Keywords: Voriconazole, UV spectrophotometry, Anti-fungal, semi-solid formulation, Beer’s Lambert’s law.
A Prospective Study on Thyroid Dysfunction and Hypertensive Disorder in Pregnant Women
Authors: Tadikonda Rama Rao , Rayeni Srujana , Jakkula Namratha , Rabia Basri 
Published: December 2023

Negative pregnancy outcomes have been linked to hypothyroidism that is not appropriately managed. Pregnancy increases the need for thyroid hormone, and many women with pre-existing hypothyroidism require higher thyroid hormone dosages in the 1st trimester. A primary cause of maternal and fetal morbidity, hypertension affects 5 to 10% of all pregnancies and is more severe when it results into preeclampsia. We have aimed for a comprehensive study of hypothyroidism and hypertension. With objectives like highlighting the most developed disorder, complications and risk factors. Finally focus on management approach.

Keywords: Hypertension, hypothyroidism, complications, risk factors, TSH, FT3, FT4.
Pemberian Pakan Berbentuk Pellet dengan Binder yang Berbeda Terhadap Kualitas Fisik, Kimia dan Mikrobiologi Daging Ayam Pedaging
Authors: Sugiarto Sugiarto , Marfuah Nuun 
Published: December 2023

Penelitian bertujuan untuk menentukan pengaruh pemberian pakan berbentuk pellet dengan binder yang berbeda terhadap kualitas fisik, kimia dan mikrobiologi daging ayam pedaging. Binder merupakan suatu bahan yang berfungsi untuk mengikat komponen bahan penyusun pakan dalam bentuk pellet sehingga strukturnya tetap kompak dan kuat, sehingga pellet yang dihasilkan lebih baik dan memberikan kualitas daging yang baik. Perlakuan terdiri dari kontrol (P0); BIS tanpa pellet (P1); BIS tanpa binder (P2); binder licndbond (P3); binder tepung durian (P4); binder kanji (P5); dan binder ketan (P6). Parameter penelitian adalah kualitas fisik daging (pH, daya ikat air, dan keempukkan), kualitas kimia (protein, kadar air, karbohidrat, abu, dan lemak daging) dan total mikroba daging. Hasil penelitian menunjukan perlakuan tidak berpengaruh (P<0,05) terhadap kualitas fisik daging: pH 6,11– 6,12, daya ikat air 21,26–22,04% dan keempukkan daging 3,07–3,22. Perlakuan juga tidak berpengaruh (P<0,05) terhadap kualitas kimia: kadar protein 20,76–22,07%, kadar air 68,45–69,79%, karbohidrat 1,02–2,50%, abu 1,12–1,52% dan lemak daging ayam 0,03–2,19%. Total mikroba tidak dipengaruhi (P<0,05) oleh perlakuan yaitu 10,78 cfu/g–11,43 cfu/g. Kesimpulan pembuatan pellet dengan menggunakan binder (bahan perekat) memberi pengaruh yang serupa pada parameter pengamatan karena kualitas pakan yang diberikan ke ayam hampir sama namun demikian ada kecenderungan kualitas kimia daging ayam lebih baik pada perlakuan binder tepung kanji.
Analisis Interaksi Biochar Tandan Kosong Kelapa Sawit (TKKS) dan Bakteri Metanotrof Terhadap Peningkatan Produksi Padi Sawah di Kabupaten Morowali
Authors: Marhani Marhani , Musa Yunus , Sahur Asmiaty , Laban Sartika 
Published: December 2023

Penelitian ini bertujuan untuk menganalisis interaksi antara dosis biochar TKKS dan konsentrasi bakteri metanotrof dalam meningkatkan produksi padi sawah, jumlah populasi bakteri dan perubahan sifat kimia tanah. Penelitian dilaksanakan di Desa Lantula Kecamatan Witaponda Kabupaten Morowali Sulawesi Tengah pada bulan Agustus sampai Desember 2021. Rancangan yang digunakan adalah Rancangan Petak Terpisah terdiri dari 2 Faktor. Petak utama dosis biochar TKKS terdiri 4 dosis yaitu: B0: tanpa biochar TKKS (kontrol), B1: biochar TKKS dosis 2 ton/ha, B2: biochar TKKS dosis 3 ton/ha, B3: biochar TKKS dosis 4 ton/ha dan Anak Petak konsenterasi bakteri metanotrof terdiri atas 4 konsenterasi yaitu: M0: tanpa bakteri metanotropik (kontrol), M1: sebanyak 5 liter res/ha, M2: bakteri 7,5 liter/ha metanotrof, M3: 10 liter/ha bakteri metanotrof masing masing perlakuan diulang sebanyak tiga kali. Data yang diperoleh dianalisis variansnya, dan jika terdapat pengaruh yang otentik dan akurat dilakukan uji lanjutan dengan uji LSD pada taraf (α 0,05). Berdasarkan hasil penelitian bahwa interaksi biochar TKKS 3 ton/ha dan bakteri menotrofik 5 liter/ha menunjukkan hasil terbaik untuk tinggi tanaman. Interaksi 4 ton biochar TKKS per ha dan 7,5 liter/ha bakteri metanotrof menunjukkan hasil terbaik untuk bobot gabah/ha, bobot gabah per petak, jumlah gabah utuh dan persentase gabah kosong terendah. Interaksi biochar TKKS dan bakteri metanotrof dapat meningkatkan pH, C organik, nitrogen, kapasitas tukar kation (KTK), Ca, Mg, Na dan P205. Total populasi bakteri tanah meningkat dari 54,05x106 (Cfu/mL) menjadi 15,85x107 (Cfu/mL) setelah penambahan biochar TKKS dan bakteri metanotrof.
REVIEW : AKTIVITAS FARMAKOLOGI DAN KADAR SENYAWA FLAVONOID TOTAL DARI TANAMAN KAPULAGA (Amomum compactum)
Authors: Irfan Muhammad , Haryoto Haryoto 
Published: December 2023

Tanaman kapulaga (Amomum compactum) adalah tanaman empon-emponan yang banyak digunakan atau dikonsumsi oleh sebagian banyak masyarakat terutama di Indonesia sebagai bumbu dapur atau sebagai pengobatan tradisional. Tanaman kapulaga terdapat senyawa metabolit sekunder seperti flavonoid, polifenol, saponin, alkaloid, steroid, dan terpenoid. Tujuan dari studi literature ini untuk mengkaji informasi terkait dari aktivitas farmakologi dan kandungan senyawa flavonoid total dari tanaman kapulaga. Metode yang digunakan adalah dengan penelusuran artikel nasional atau internasional dengan menggunakan data base Google scholar, pubmed, dan scientdirect. Kata kunci yang digunakan adalah Amomum compactum, dan flavonoid. Selanjutnya kriteria inklusi yang dipakai adalah literature primer yang sudah dipublikasi dengan rentang tahun 2012-2022 dengan membahas aktivitas farmakologi dan kadar senyawa flavonoid total dari tanaman kapulaga. Kriteria eksklusi adalah artikel yang membahas tentang aktivitas farmakologi dan kadar senyawa flavonoid total dari tanaman kapulaga yang dipublikasi sebelum tahun 2012 dan tidak dapat diakses secara menyeluruh atau full text. Studi literatur ini menunjukkan tanaman kapulaga memiliki potensi sebagai antibakteri, antioksidan, antidiabetes, sitotoksik, antiinflamasi, dan antikarsinogenik.
AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI RIMPANG LENGKUAS PUTIH (Alpinia galanga) TERHADAP BAKTERI Pseudomonas aeruginosa DAN Bacillus subtilis SERTA BIOAUTOGRAFINYA
Authors: Puspita Indah Tri , Muflihah Cita Hanif 
Published: December 2023

Infeksi adalah penyakit yang dapat menimbulkan gejala klinis atau asimtomatis yang dipicu oleh mikroorganisme seperti bakteri. Pseudomonas aeruginosa dan Bacillus subtilis merupakan bakteri yang dapat menimbulkan infeksi nosokomial. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri dari ekstrak dan fraksi rimpang lengkuas putih (Alpinia galanga) terhadap bakteri Pseudomonas aeruginosa dan Bacillus subtilis dan mengidentifikasi golongan senyawa yang berperan sebagai agen antibakteri. Ekstrak diperoleh dari maserasi lengkuas menggunakan metanol 70%. Metode difusi disk dipilih dalam uji aktivitas antibakteri. Sampel yang diuji adalah ekstrak dengan konsentrasi 10,5; 12; 13,5; dan 15 mg/disk, fraksi metanol 15 mg/disk, fraksi etil asetat 15 mg/disk, fraksi kloroform 15 mg/disk, kloramfenikol sebagai kontrol positif, dan DMSO sebagai kontrol negatif. Hasil uji ekstrak metanol menunjukkan adanya aktivitas antibakteri terhadap Pseudomonas aeruginosa dan Bacillus subtilis pada konsentrasi 15 mg/disk dengan diameter zona hambat berturut-turut adalah 13,5 ± 0,41 mm dan 16,0 ± 0,41 mm. Hasil uji fraksi etil asetat menunjukkan adanya aktivitas antibakteri terbesar terhadap Pseudomonas aeruginosa dan Bacillus subtilis dengan diameter zona hambat berturut-turut adalah 12,0 ± 0,41 mm dan 13.7 ± 0,24 mm. Identifikasi golongan senyawa rimapang lengkuas putih (Alpinia galanga) menggunakan metode KLT dengan silika gel GF254 sebagai fase diam, kloroform : etil asetat (1:1 v/v) sebagai fase gerak untuk mengelusi plat ekstrak, dan kloroform : metanol (9:3 v/v) sebagai fase gerak untuk mengelusi plat fraksi etil asetat. Hasil uji fitokimia rimpang lengkuas putih (Alpinia galanga) menunjukkan ekstrak metanol positif mengandung alkaloid, fenolik, flavonoid, dan terpenoid, sedangkan pada fraksi etil positif mengandung fenolik, flavonoid, dan terpenoid. Uji bioautografi menunjukkan golongan senyawa yang mampu menghambat bakteri Pseudomonas aeruginosa dan bakteri Bacillus subtilis adalah fenolik, flavonoid, dan terpenoid.