bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panel VAR model applied to foreign trade between Portugal and regional economic blocs
Authors: Sandambi Nerhum 
Published: November 2023

Abstract
The study analyses foreign trade between Portugal and the regional economic blocs in the period 1980-2018. The main objective of the study is to analyse the behaviour of the volume of foreign trade transacted between Portugal and the regional blocs, to understand which impacts significantly influence trade and to analyse whether foreign trade is influenced by economic and physical distances. Thus, a dynamic panel VAR model was estimated, where the initial aim was to understand the effects of Impulse Response Functions (IRFs). The results show a positive impact on the volume of trade. This impact is related to a considerable increase in the GDP of the regional blocs under analysis, for example. On the other hand, the Impulse Response Functions allow us to show the behaviour of the variables, but there is no plausible influence. On the one hand, this is due to the fact that the economies under analysis have stable currencies. The oil price variable, for example, shows a positive impact, above all, depending on positive shocks in the international oil market, but there is a 78.5% positive impact on the volume of trade transacted. The tariff variable with a negative impact is associated with the different levels of trade policy application, with the trade policy applied with the PALOP countries, the EU, South Africa and Brazil being strictly different, and external debt having a negative impact on the volume of trade transacted.
JEL classification: c01; c21; c23; c33; F10.
Cardiac-Specific Gene TNNI3 Acts as a Potential Oncogene for Papillary Renal Cell Carcinoma
Authors: Cai Biao , Chen Xiaoxiang , Yang Lu , Huang Wenqi , Zhao Weian 
Published: November 2023

Abstract
Background: The TNNI3 gene, responsible for encoding the inhibitory subunit of the troponin complex known as cardiac troponin I (cTnI), has significant implications in cardiology research. Despite reports of its abnormal expression in human carcinoma cells, the precise functions of TNNI3 in cancer remain largely unexplored. The present study seeks to examine the prognostic significance of TNNI3 in papillary renal cell carcinoma (pRCC). Methods: The mRNA expression profiles were acquired from the Cancer Genome Atlas (TCGA) database to identify candidate prognostic genes using univariate Cox analysis, log-rank test, and the least absolute shrinkage and selection operator (LASSO) analysis. A prognostic risk formula was established through multivariable Cox regression analysis. Additionally, Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and immune-related function analyses were conducted. Furthermore, western blot, cell proliferation assay, and wound healing assay were employed to validate the in vitro biological effects of TNNI3. Results: A total of 361 differentially expressed genes (DEgenes) were found to be correlated with TNNI3 expression. A prognostic risk formula including the genes PTPRH, LGR5, and DMRT3 was then formulated. Notably, the low-risk group demonstrated superior overall survival (OS) outcomes compared to the high-risk group, as observed in both the training and validation cohorts. To further elucidate the potential functions of these three genes, a target gene network was constructed. Subsequent GO and KEGG analyses revealed their involvement in the Wnt signaling pathway, which was confirmed through western blot experiment. Furthermore, cellular experiments demonstrated that TNNI3 promotes the proliferation and metastasis of pRCC cells. Lastly, immune analyses indicated that increased expression of TNNI3 in pRCC is associated with a poorer response to immunotherapy. Conclusion: TNNI3 might function as an oncogene via activating Wnt signaling pathway in pRCC and a three-gene signature related to TNNI3 could serve as a prognostic biomarker for pRCC.
Economic value of virtual water with the approach of maximizing the productivity of irrigation water
Authors: Du Linyuan 
Published: November 2023

Abstract
The increasing use of water and the decrease in average rainfall along with climate change have caused the reduction of water resources in arid and semi-arid regions. In addition, despite the consumption of more than half of these resources in the agricultural sector, a rate between 0 and 15% of the price of the products has always been received from the farmers. Considering the concept of virtual water and the water content of products in the form of green water, blue water and gray water, the present research has calculated the economic value of virtual water of agricultural products with the approach of maximizing water use efficiency. The investigated sample includes eight cities (counties) of Sanmenxia, Jiaozuo, Nanyang, Shangqiu, Puyang, Luohe, Luoyang and Kaifeng and six agricultural products (wheat, barley, potato, rapeseed, tomato and corn). A fuzzy dynamic programming model has been used to evaluate the objective function. The results showed that the maximum and minimum economic value of water content (sum of surface and groundwater) of the products were estimated for Kaifeng and Shangqiu regions equal to 1.16 and 0.86 Yuan/m3, respectively.
Drug Discovery Efforts to Identify Novel Treatments for Neglected
Tropical Diseases - Cysteine Protease Inhibitors
Authors: Giroud Maude , Kuhn Bernd , Haap Wolfgang 
Published: November 2023

Background:
Neglected tropical diseases are a severe burden for mankind, affecting
an increasing number of people around the globe. Many of those diseases are
caused by protozoan parasites in which cysteine proteases play a key role in the parasite’s
pathogenesis.

Objective:
In this review article, we summarize the drug discovery efforts of the research
community from 2017 - 2022 with a special focus on the optimization of small
molecule cysteine protease inhibitors in terms of selectivity profiles or drug-like properties
as well as in vivo studies. The cysteine proteases evaluated by this methodology include
Cathepsin B1 from Schistosoma mansoni, papain, cruzain, falcipain, and rhodesain.

Methods:
Exhaustive literature searches were performed using the keywords “Cysteine
Proteases” and “Neglected Tropical Diseases” including the years 2017 - 2022. Overall,
approximately 3’000 scientific papers were retrieved, which were filtered using specific
keywords enabling the focus on drug discovery efforts.

Results and Conclusion:
Potent and selective cysteine protease inhibitors to treat neglected
tropical diseases were identified, which progressed to pharmacokinetic and in
vivo efficacy studies. As far as the authors are aware of, none of those inhibitors reached
the stage of active clinical development. Either the inhibitor’s potency or pharmacokinetic
properties or safety profile or a combination thereof prevented further development of
the compounds. More efforts with particular emphasis on optimizing pharmacokinetic
and safety properties are needed, potentially by collaborations of academic and industrial
research groups with complementary expertise. Furthermore, new warheads reacting
with the catalytic cysteine should be exploited to advance the research field in order
to make a meaningful impact on society.
Deacetylation of Histones and Non-histone Proteins in Inflammatory
Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors
Authors: Man Ezgi , Evran Serap 
Published: November 2023

abstract:
Epigenetic changes play an important role in the pathophysiology of autoimmune diseases
such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis,
rheumatoid arthritis, and COVID-19. There are three main classes of epigenetic alterations: posttranslational
modifications of histone proteins, control by non-coding RNA and DNA methylation.
Since histone modifications can directly affect chromatin structure and accessibility, they can regulate
gene expression levels. Abnormal expression and activity of histone deacetylases (HDACs) have been
reported in immune mediated diseases. Increased acetylated levels of lysine residues have been suggested
to be related to the overexpression of inflammatory genes. This review focuses on the effect of
HDAC modifications on histone and non–histone proteins in autoimmune diseases. Furthermore, we
discuss the potential therapeutic effect of HDAC inhibitors (HDACi) used in these diseases.
Application Potential of Radiomics based on the Unenhanced CT Image for the
Identification of Benign or Malignant Pulmonary Nodules
Authors: Zhang Ling , Zeng Bingliang , Liu Jiaqi , Lin Huashan , Lei Pinggui , Fan Bing , Xu Rong 
Published: November 2023

Objective::
With the rapid development in computed tomography (CT), the establishment of artificial intelligence (AI) technology and improved awareness of
health in folks in the decades, it becomes easier to detect and predict pulmonary nodules with high accuracy. The accurate identification of benign
and malignant pulmonary nodules has been challenging for radiologists and clinicians. Therefore, this study applied the unenhanced CT imagesbased
radiomics to identify the benign or malignant pulmonary nodules.

Methods::
One hundred and four cases of pulmonary nodules confirmed by clinicopathology were analyzed retrospectively, including 79 cases of malignant
nodules and 25 cases of benign nodules. They were randomly divided into a training group (n = 74 cases) and test group (n = 30 cases) according
to the ratio of 7:3. Using ITK-SNAP software to manually mark the region of interest (ROI), and using AK software (Analysis kit, Version 3.0.0.R,
GE Healthcare, America) to extract image radiomics features, a total of 1316 radiomics features were extracted. Then, the
minimum–redundancy–maximum–relevance (mRMR) algorithms were used to preliminarily reduce the dimension, and retain the 30 most
meaningful features, and then the least absolute shrinkage and selection operator (LASSO) algorithm was used to select the optimal subset of
features, so as to establish the final model. The performance of the model was evaluated by using the receiver operating characteristic (ROC)
curve, area under the ROC curve (AUC), accuracy, sensitivity and specificity. Calibration refers to the agreement between observed endpoints and
predictions, and the clinical benefit of the model to patients was evaluated by decision curve analysis (DCA).

Results::
The accuracy, sensitivity, and specificity of the training and testing groups were 81.0%, 77.7%, 82.1% and 76.6%, 85.7%, 73.9%, respectively, and
the corresponding AUCs were of 0.83 in both groups.

Conclusion::
CT image-based radiomics could differentiate benign from malignant pulmonary nodules, which might provide a new method for clinicians to
detect benign and malignant pulmonary nodules.
Multifunctional Drug Delivery System: Nanosponges
Authors: Barik Piyali , Bhaisal Pooja Rani , Singh Sonia 
Published: November 2023

Abstract:
In recent years, nanotechnology has been the focus of study for the cure of different diseases, among which nanosponge delivery system is one of a kind. Nano sponges are tiny, highly porous,
three-dimensional nanostructures with a size range of 250nm-1µm in an amorphous or crystalline
structure. Nanosponges usually act as an excipient or carrier of a drug in the different delivery systems.
The type of polymers and cross-linkers, along with their concentration ratio, causes variation in nanosponges's dimension and encapsulation efficiency. Nanosponges have gained prominence in recent
times due to their distinct ability to encapsulate both hydrophilic and lipophilic drugs within their internal cavity, thereby improving the solubility of drugs that have low water solubility. Virus-like size
helps the nanosponges to circulate within the body without getting eliminated by the immune system
until they stick to the targeted part of the body, which makes it the perfect candidate for a targeted drug
delivery system and controlled delivery system as well because of its slow drug release property for a
more extended period. Cyclodextrin-based nanosponges are the best choice for anticancer drug delivery as their small virus-like diameter helps them in passive targeting by enhancing the enhanced permeability and retention effect, allowing the anticancer drug to stay inside the tumour cell to show more
significant therapeutic action on cancer, while for active targeting to the cancerous cell, nanosponges
are attached with a ligand on it for receptor binding purpose. It can be used for drug delivery in many
major diseases like brain-related diseases, diabetes, cancer, fungal, hypertension, etc., in different dosage forms, like oral, topical, hydrogel, parenteral, etc.
Rewriting – Republishing – Distribution
Authors: Wirágh András 
Published: November 2023

Abstract
Contemporary press networks played a significant role in shaping the literary career-building strategies of Hungarian writers at the fin-de-siècle. Several of these writers served as journalists or maintained ties with numerous newspapers concurrently. The networks involved in the publication of an author’s text reveal valuable information on the operations of the literary institution (the literary establishment) during the era, particularly in the careers of relatively unknown authors like László Cholnoky. During the early years of his career, Cholnoky’s strategies diverged from those of his contemporaries in several ways: he refrained from publishing his first volume for an extended period, withdrew from publishing intermittently, and revised his work more frequently than others. This paper will investigate the publication networks Cholnoky utilised between the years 1900 and 1914, shedding light on the unique aspects of publishing and networking relevant in three periods.
Romania’s 1866 Electoral System and the Quest for National Sovereignty
Authors: Roghină Răzvan Cosmin 
Published: November 2023

Abstract
In 1866, religion played a significant role in unifying the Romanian national spirit. A foreign prince was brought to rule under the Orthodox faith, and this religious aspect was incorporated into Article 82 of the Constitution.
The limitation of political rights in Romania was based on ethnic criteria, with Jews and other non-Christians excluded from full participation. The electoral system introduced a high property-based voting qualification, reflecting, to some extent, liberal principles, but effectively limiting actual participation.
Thus, the Romanian Constitution of 1866 struck a delicate balance between borrowed liberal ideals and the specific cultural context of Romania. It emphasized the role of religion and property ownership in shaping political rights and identity, while also attempting to align with European constitutional standards. The electoral system of 1866 in Romania fell short of democratic ideals and perpetuated inequalities. It shaped the political landscape and had far-reaching consequences for the country’s governance and representation.
Protection of Private, Family, and Intimate Lives
Authors: Moroșteș Anca Florina 
Published: November 2023

Abstract
The Constitutional Court of Romania (CCR) holds an essential position in guaranteeing the observance of human rights within the country’s constitutional and legal framework. Through its attribution to interpret and verify the compliance of laws with the Constitution, the CCR has built a vast and particularly significant caselaw regarding the individual’s fundamental rights. By studying the Constitutional Court of Romania’s judicial practice in the field of human rights, we can examine how fundamental rights are interpreted and implemented in the national legal system. In this regard, the CCR plays a vital role in ensuring the protection and promotion of these rights by interpreting the Constitution and applicable legislation in accordance with international standards. It is important to highlight that the CCR’s human rights caselaw reflects the constant attempt to ensure a balance between the individual’s and society’s interests, protecting fundamental rights in accordance with the principles of the rule of law and international standards in the field. Through the analysis of concrete cases and constitutional interpretation, the CCR strengthens its essential role in human rights promotion and defense in Romania.
Tax Evasion Between Tax Optimization at the Border of Legality, Tax Burden and Voluntary Compliance
Authors: Petrașcu Daniela , Păcurariu Ioana , Ciocanea Bianca Cristina , Pițu Cosmin Ioan 
Published: November 2023

Abstract
Tax evasion operates beyond the boundaries of the jurisdictions, it develops across borders, and the extent of tax fraud as a phenomenon is differentiated according to the aspects and the rigours of legislation, as well as according to the economic environment of each country in part. Regardless of the level of development of the country in which it manifests, the effects of the fiscal fraud are destructive, affecting both the state budget, as well as the financial resources of the offenders’ commercial partners. The fiscal fraud has negative effects over the economic market, and one of the consequences is the social inequality from the perspective of the abuse and the predisposition of certain taxable subjects to fraud. Certainly, the phenomenon remains unraveled, the financial schemes being extremely complex, and the fraud mechanisms are some of the most laborious ones and in a permanent improvement, while the evaders keep finding new means by way of which they illegally attract financial resources. The fight against tax evaders is a difficult one, mainly because of the sometimes “deliberate” legislative “loopholes”, but also because of their ingenuity, which is often “one step” ahead of those who fight against tax evasion.
Predicting life expectancy of lung cancer patients after thoracic surgery using SMOTE and machine learning approaches
Authors: KHARIS SELLY ANASTASSIA AMELLIA , ZILI ARMAN HAQQI ANNA 
Published: November 2023

. Lung cancer is a life-threatening condition characterized by the uncontrolled growth and spread of abnormal cells in the lungs. Thoracic surgery is a commonly employed diagnostic and treatment procedure for lung cancer. The objective of this study is to utilize machine learning techniques to predict the life expectancy of lung cancer patients one year after thoraric surgery. The study utilizes the Thoraric Surgery Data Set, consisting of 454 data, with 385 data representing surviving patients and 69 data representing patients who passed away. Due to an imbalance in the data, the Synthetic Minority Oversampling Technique (SMOTE) process is applied to balance the dataset. Multiple machine learning algorithms, including Random Forest (RF), K-Nearest Neighbor (KNN), and Support Vector Machine (SVM), are employed for prediction. Validation is performed using 5-fold cross validation, repeated three times. The results indicate that the KNN model achieves the highest mean accuracy of 84.80% before the SMOTE process, although all models exhibit a low mean F1-score. Following the SMOTE process, the RF model attains the highest mean accuracy of 79.52%, while the KNN model demonstrates the highest mean F1-score of 26.54%. This research contributes valuable insights to clinicians in making informed decisions and improving patient outcomes.
Towards Unlocking/Tuning the Mott Transition Temperature in Alkaline-Doped Vanadium Oxide Thermochromic Coatings and Potential Green Air-Conditioning via Room Temperature VxOy-V-VxOy Layered Coatings
Authors: Khanyile Sfundo , Numan Nagla , Simo Aline , Nkosi Mlungisi , Mtshali Christopher Bongani , Khumalo Zakhelumuzi , Madiba Itani Given , Mabakachaba Boitumelo , Swart H. , Coetsee E. , Duvenhage M. , Lee E. , Henini M. , Gibaud A. , Kennedy J. , Chaker M. , Maaza Malek 
Published: November 2023

In this contribution, we validate for the first time that the near infrared-infrared (NIR-IR) modulation of the optical transmission (DTTRANS = T(T<TMIT) - T(T>TMIT)) of vanadium oxide-based nanomaterials can be controlled or tuned via a genuine approach with a simultaneous drastic reduction of its Mott transition temperature TMIT. More accurately, we report a significant thermochromism in multilayered V2O5/V/V2O5 stacks equivalent to that of pure VO2 thin films but with a far lower transition temperature TMIT. Such a multilayered V2O5/V/V2O5 thermochromic system exhibited a net control or tunability of the optical transmission modulation in the NIR-IR (DTTRANS) via the nano-scaled thickness of the intermediate vanadium layer. In addition, the control of DTTRANS is accompanied by a noteworthy diminution of the Mott transition temperature TMIT from the bulk value of 68.8 °C to the range of 27.5–37.5 °C. The observed peculiar thermochromism in the multilayered V2O5/V/V2O5 is likely to be ascribed to a significant interfacial diffusion or an excessive interfacial stress/strain, and/or to an effective halide (Na, K, Ca) doping. This doping is driven by a significant diffusion from the borosilicate substrate surface towards the V2O5/V/V2O5 stacks. If the upscaling of this approach is validated, the current findings would contribute to advancing thermochromic nanomaterials and their applications in smart windows for managing solar heat and green air-conditioning technologies.
STRENGTHENING COMMUNITY CHARACTER AND LITERATURE IN HANDLING STUNTING THROUGH VILLAGE DIGITALIZATION IN GUWOSARI SUB-DISTRICT
Authors: Apriani An-Nisa , Rouzi Kana Safrina , Putri Mufida Awalia , Paratmanitya Yhona , Maula Defia Ifsantin , Rohaendy Endi , Sukati Sukati , Badriah Laelatul , Heksaputra Dadang , Saputri Rizky 
Published: November 2023

TPA cadres' understanding toward the role of Quran literacy, Living Values Education Program (LVEP), business & economy and literacy digitization in stunting handling is still inadequate. Strengthening their literacy in handling stunting is needed to prevent stunting problems in the TPA environment. This community service activities aim to increase the understanding of TPA cadres pertainin the Quran literacy, LVEP, business, economics, and digitalization as one of the programs to strengthen community literacy in stunting control. The main activity of the workshop is in the form of training using the lecture method, question and answer, and discussion. The community service activities are carried out through three stages, namely preparation, implementation, and evaluation. The participation and enthusiasm of the TPA cadres in the activity was very good, the partner group contributed actively in the workshops on strengthening community character and literacy in handling stunting through village digitization in the Guwosari sub-district.
Gisi Marimas: Giat Literasi Dengan Makan Bergizi Dan Minum Yang Sehat Bersama Perpustakaan Cemerlang Desa Watualang
Authors: Hikmawati Hanifah 
Published: November 2023

Abstract; This article discusses the importance of eating nutritious food and drinking healthy which is echoed by the Watualang Village Cemerlang Library to the community. Cemerlang Library is a library transformation based on social inclusion that focuses on community welfare and as a problem solver for phenomena that occur in society. One of the breakthroughs of social inclusion is the Cemerlang library of Watualang village in the form of the "Gisi Marimas" activity which stands for "Active Literacy by Eating Nutritious and Drinking Healthy". The research method is in the form of descriptive qualitative, by describing words and statements as well as evaluating validity through cross-checking of information sources. The results of the research show that the Watualang village Cemerlang library intensively organizes progressive activities in the form of food processing practicum activities. The results of Gisi Marimas can support the body's source of nutrition and energy. Regular consumption of healthy food can also provide many benefits, ranging from boosting immunity, strengthening muscles and bones, reducing the risk of chronic disease, improving digestion, and maintaining ideal body weight.
Keywords; Literacy, Nutritious Food, Healthy Drinks, Brilliant Library of Watualang Village, Social Inclusion