bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal fractional flow reserve: A hemodynamic evaluation of moderate renal artery stenoses
Authors: Subramanian Rajesh , White Christopher J. , Rosenfield Kenneth , Bashir Riyaz , Almagor Yaron , Meerkin David , Shalman Evgeny 
Published: March 2005

AbstractThe objective of this study was to perform a hemodynamic evaluation of moderate (50–90%) renal artery stenosis (RAS) under conditions of rest and maximum hyperemia. Identifying patients with RAS who have hemodynamically significant stenoses and are most likely to benefit from revascularization is clinically important. Current methods used to evaluate RAS, including angiography, have limitations. Physiologic evaluation of RAS may have a role in identifying patients with hemodynamically significant stenosis. Patients with suspected renovascular hypertension due to aorto‐ostial RAS were included in the study. Hyperemia was induced by administration of intrarenal papavarine. Translesional pressure gradients were measured and renal fractional flow reserve (FFR) was calculated using a 0.014″ pressure guidewire. Thirteen patients and 14 arteries with moderately severe (50–90%) RAS were studied. The mean translesional pressure gradient rose from a baseline of 6.3 ± 3.9 to 17.5 ± 10.8 mm Hg with maximal hyperemia. The renal FFR ranged from 0.58 to 0.95. There was a poor correlation between angiographic stenosis measurement and the renal FFR (r = −0.18; P = 0.54) and the hyperemic translesional mean pressure gradient (r = 0.22; P = 0.44). There was an excellent correlation between renal FFR and the resting mean translesional pressure gradient (r = −0.76; P = 0.0016) and the hyperemic mean translesional pressure gradient (r = −0.94; P < 0.0001). Selective renal arterial papavarine administration induces maximum hyperemia, permitting the calculation of renal FFR in renal arteries with aorto‐ostial stenoses. The renal FFR correlates well with other hemodynamic parameters of lesion severity, but poorly with angiographic measures of lesion severity. Catheter Cardiovasc Interv 2005;64:480–486. © 2005 Wiley‐Liss, Inc.
Identification of cDNAs associated with late dedifferentiation in adult newt forelimb regeneration
Authors: Vascotto Sandy G. , Beug Shawn , Liversage Richard A. , Tsilfidis Catherine 
Published: March 2005

AbstractEpimorphic limb regeneration in the adult newt involves the dedifferentiation of differentiated cells to yield a pluripotent blastemal cell. These mesenchymal‐like cells proliferate and subsequently respond to patterning and differentiation cues to form a new limb. Understanding the dedifferentiation process requires the selective identification of dedifferentiating cells within the heterogeneous population of cells in the regenerate. In this study, representational differences analysis was used to produce an enriched population of dedifferentiation‐associated cDNA fragments. Fifty‐nine unique cDNA fragments were identified, sequenced, and analyzed using bioinformatics tools and databases. Some of these clones demonstrate significant similarity to known genes in other species. Other clones can be linked by homology to pathways previously implicated in the dedifferentiation process. These data will form the basis for further analyses to elucidate the role of candidate genes in the dedifferentiation process during newt forelimb regeneration. Developmental Dynamics 233:347–355, 2005. © 2005 Wiley‐Liss, Inc.
Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning
Authors: Götz Katrin , Briscoe James , Rüther Ulrich 
Published: March 2005

AbstractSonic hedgehog (Shh), produced by the notochord and floor plate cells of the neural tube, plays a critical role in organizing dorsal–ventral patterning in the developing neural tube. We have investigated neural tube development in mouse embryos homozygous for the Fused toes (Ft) mutation, a deletion composed of genes of the Iroquois B (IrxB) cluster and of Fts, Ftm, and Fto. In Ft mutants starting from embryonic day 10.5, the floor plate appeared to degenerate and the notochord failed to undergo ventral displacement from the spinal cord. Consistent with the loss of Shh signalling from the floor plate, V3 neuron generation was reduced in Ft/Ft embryos and the domain of motor neuron generation expanded ventrally at the expense of V2 neurons. These data support the idea that Ft genes play an important role in dorsal–ventral patterning of the neural tube acting to define the extent of motor neuron generation; moreover, the data reveal a previously unanticipated function for Ft genes in the maintenance of the floor plate. Developmental Dynamics 233:623–630, 2005. © 2005 Wiley‐Liss, Inc.
New Insights into the Stoichiometric and Catalytic Reactivity of Unsaturated Pd3(dppm)3COn+ Clusters (n = 0, 1) Towards Halocarbons – First Evidence for Inorganic By‐Products
Authors: Lucas Dominique , Lemaître Frédéric , Gallego‐Gómez Beatriz , Cugnet Cyril , Richard Philippe , Mugnier Yves , Harvey Pierre D. 
Published: March 2005

AbstractThe title clusters, Pd3(dppm)3(CO)+ and Pd3(dppm)3(CO)0 can be electrochemically generated from the 1‐ and 2‐electron reductions, respectively, of the Pd3(dppm)3(CO)2+ cluster [dppm = bis(diphenylphosphanyl)methane; Pd32+]. Pd3+ reacts in a stoichiometric ratio with methyl iodide, MeI, and benzyl bromide, BzBr, in THF to provide the corresponding Pd3(X)+ adducts (X = I, Br respectively) as inorganic products. Other products are Bz2 and PhMe for BzBr but, for MeI, no organic product was observed (since they are too volatile). In the presence of the same substrates, Pd30 also reacts in a stoichiometric ratio to form the same organics and the Pd3‐(X)+ adducts (X = I and Br). However for MeI, the major inorganic product is the A‐frame Pd2(dppm)2(Me)2I+ binuclear complex. For BzBr, the corresponding A‐frame complex Pd2(dppm)2(Bz)2Br+ could not be detected. The spin‐trap agents, 2,2,6,6‐tetramethylpiperidin‐1‐oxyl (TEMPO) and 5,5′‐dimethyl‐1‐pyrroline N‐oxide (DMPO), have been used to demonstrate the intermediacy of the radical Bz·. The catalytic generation of “Bz·” was performed using two methods, i.e. 1) using a copper anode as the working electrode [Pd3‐(Br)+ + Cu – e– → Pd32+ + CuBr (s)] and 2) using a carbon cathode as the working electrode [Pd3(Br)+ + 2e– → Pd30 + Br–]. The chemical yields for Bz2 vary between 50 and 56 % and the Faradic yield is of the order of 90 % for method 1 and between 52 and 59 % for method 2 [taking into account the quantity of electricity necessary to reduce the catalyst Pd3‐(Br)+]. The X‐ray structure of Pd3(dppm)3(CO)(Br)+ is presented and the following parameters were recorded: monoclinic space group P21/n, a = 10.6546(2), b = 37.1091(7), c = 21.2714(7) Å, β = 91.55(1)o, V = 8407.3(4) Å3, Z = 4, R1 = 0.0581 [I > 2σ(I)], wR2 = 0.1478 (all data). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Synthesis, Characterization and Coordination Chemistry of Some Selenium‐Containing Macrocyclic Schiff Bases
Authors: Panda Arunashree , Menon Saija C. , Singh Harkesh B. , Morley Christopher P. , Bachman Robert , Cocker T. Matthew , Butcher Ray J. 
Published: March 2005

AbstractThe condensation of bis(o‐formylphenyl) selenide with 1,2‐diaminoethane or 1,3‐diaminopropane yielded the new macrocyclic ligands 1 and 2 in very good yields. Crystals of 1 are monoclinic, space group P21/c with a = 10.0648(10) Å, b = 37.390(4) Å, c = 8.0073(11) Å, Z = 4 and those of 2 are triclinic, space group P$\bar {1}$ with a = 7.200(3), b = 9.137(3), c = 12.780(6) Å, Z = 1. The coordination chemistry of 1 and 2 has been studied with the “soft” metal ion PdII and “hard” metal ions NiII and CoII. Reaction of [PdCl2(COD)] with 1 mol‐equiv. of 1 or 2 in refluxing methanol and addition of NH4PF6 afforded the PdII complexes 5 and 6, respectively. Compound 5 is an unexpected partially hydrolyzed complex. It crystallizes in the tetragonal space group P41212 with a = 10.7737(10) Å, b = 10.7737(10) Å, c = 28.190(5) Å, Z = 4. The structure shows the PdII ion coordinated to a square‐planar arrangement of two selenium and two nitrogen atoms. Reaction of NiCl2·6H2O with 1 or 2 and NH4PF6 yielded complexes 7 and 8, respectively. The assignment of octahedral geometries to [Ni(L)](PF6)2] (7: L = 1; 8: L = 2) follows from their paramagnetism [μeff = 3.23 (7), 1.81 (8) B.M.] and their UV/Vis spectra. This was also confirmed by single‐crystal X‐ray studies. The crystal structures of 7 and 8 showed a distorted octahedral nickel center coordinated by two selenium and four nitrogen atoms. 7: Monoclinic, space group P21/c; a = 9.979(2) Å, b = 18.901(4) Å, c = 19.333(4) Å; Z = 4. 8:Orthorhombic, space group Pna21; a = 20.277(5), b = 20.865(5), c = 9.416(2) Å; Z = 4. The cyclic voltammograms of 7 and 8 in MeCN solution show well‐behaved quasi‐reversible NiIII/NiII couples. The analogous CoII complex, [Co(1)](PF6)2] (9) also shows a quasi‐reversible CoIII/CoII couple. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
A Tetranuclear Hydroxo‐Bridged Copper(II) Complex with PrimaryN‐Acylamidines as Ligands: Preparation, Structural, and Magnetic Characterisation
Authors: Eberhardt Jan K. , Glaser Thorsten , Hoffmann Rolf‐Dieter , Fröhlich Roland , Würthwein Ernst‐Ulrich 
Published: March 2005

AbstractThe reaction of N‐pivaloylbenzamidine (1a) and tetrakis(acetonitrile)copper(I) hexafluorophosphate in the presence of air yields a hydroxo‐bridged copper(II) complex (4). The product was characterised by X‐ray diffraction analysis and found to be a cubane‐like dimeric complex consisting of two square dimers with the formula [{(1a)2Cu2(OH)2}2](PF6)4·4 CH2Cl2 (4·4 CH2Cl2) with cupric ions and hydroxyl oxygen atoms at alternating vertices of a cube. The complex can be described as consisting of two [ligand‐Cu‐(OH)2‐Cu‐ligand] units held together by long out‐of‐plane Cu–O bonds, creating a tetrameric entity with a Cu4(OH)4 core. Each cupric ion is essentially square‐pyramidally coordinated, being bound to three OH bridges, one N atom of the amidine and one N‐acylamidine O atom. The magnetic properties of this compound have been studied in the 2–300 K temperature range. The measurements revealed that the cupric ions in the cube are antiferromagnetically coupled. This observation has been rationalised on the basis of the structural data. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Stereoisomerism in Pentaerythritol‐Bridged Cyclotriphosphazene Tri‐Spiranes: Spiro and Ansa 1,3‐Propanediyldioxy Disubstituted Derivatives
Authors: Uslu Aylin , Coles Simon J. , Davies David B. , Eaton Robert J. , Hursthouse Michael B. , Kılıç Adem , Shaw Robert A. 
Published: March 2005

AbstractFour isomeric products were isolated and purified from the reaction of 1,3‐propanediol with the tri‐spirane cyclophosphazene‐organophosphate compound 1: viz. the di‐monospiro (2a), di‐monoansa (2b) and two monospiro‐monoansa derivatives (2c and 2d). It is shown by 31P NMR spectroscopy on addition of a chiral solvating agent (CSA) that both the di‐monospiro 2a and di‐monoansa 2b derivatives are racemates, as expected, whereas no splitting of NMR signals occurred on addition of CSA to solutions of 2c and 2d. It is found by X‐ray crystallography that the two monospiro‐monoansa spirane derivatives, 2c and 2d, are meso diastereoisomers, which represent a new case of the stereochemistry of bis(disubstituted) cyclophosphazene derivatives of 1. It is also observed from the 31P NMR spectrum of the reaction mixture, supported by the yields of pure compounds, that formation of a spiro group is about 4.5 times more likely than that of an ansa moiety under the conditions of the reaction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
S‐phase entry of oligodendrocyte lineage cells is associated with increased levels of p21Cip1
Authors: Bansal Rashmi , Marin‐Husstege Mireya , Bryant Melissa , Casaccia‐Bonnefil Patrizia 
Published: March 2005

AbstractThe mechanisms regulating the number of myelinating cells in the central nervous system are crucial for both normal development and repair in pathological conditions. Among relevant growth factors involved in this process, fibroblast growth factor‐2 (FGF2) induces oligodendrocyte progenitors (OLPs) to proliferate and stimulates mature oligodendrocytes (OLs) to reenter the S‐phase of the cell cycle. S‐phase entry is modulated by the formation of complexes between cyclins and cyclin‐dependent kinases (CDKs), on one hand, and by their interactions with cell cycle inhibitors (e.g., p18INK, p27Kip1, p21Cip1), on the other. Although the roles of cyclin E/CDK2 complexes and the inhibitor p27Kip1 have been extensively investigated relative to proliferation and differentiation in the OL lineage, less is known about the regulation of the formation of cyclin D1/CDK4 complexes and the role of p21Cip1 in these events. In this study, we show that the FGF2‐mediated increase in bromodeoxyuridine (BrdU) incorporation into OL progenitors and mature OLs occurs concomitantly with increase in the levels of p21Cip1 and the formation of p21Cip1/cyclin D1/CDK4 ternary complexes. These complexes are functionally active is indicated by the ensuing FGF2‐dependent hyperphosphorylation of the downstream target Rb. In untreated mature OLs that do not incorporate BrdU, the levels of p21Cip1 are low, and the level of the inhibitor p18INK is high. Furthermore, p18INK sequesters CDK2 into binary complexes, precluding the formation of p21Cip1/cyclin D1/CDK4 ternary complexes in these cells. Therefore, we propose that p21Cip1 is acting as a positive regulator, rather than an inhibitor, of cell cycle entry by favoring the assembly of active cyclin D1/CDK4 complexes. © 2005 Wiley‐Liss, Inc.
Influence of socioeconomic status on lung function and prediction equations in Indian children
Authors: Raju P. Sitarama , Prasad K.V.V. , Ramana Y. Venkata , Balakrishna N. , Murthy K.J.R. 
Published: March 2005

AbstractThe present study was carried out to assess the influence of socioeconomic status on lung functions and to suggest prediction equations for Indian children. For this purpose, 2,616 normal, healthy schoolchildren aged between 5–15 years were recruited. Boys were classified into three groups, i.e., high‐income (HIG), middle‐income (MIG), and low‐income (LIG), while girls were classified into HIG and LIG groups, based on socioeconomic status (SES). Height, weight, chest circumference, body surface area (BSA), fat‐free mass (FFM), and body fat were assessed. Forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and peak expiratory flow rate (PEFR) were measured. The results, before and after adjustment of physical characteristics, showed that anthropometry, body composition, and lung functions were significantly higher in HIG compared to MIG and LIG children, while in girls, no differences were observed in physical characteristics after adjustments. Multiple linear regression equations were developed to predict FEV1, FVC, and PEFR, using independent variables like age, height, fat‐free mass, and SES. It is opined that these equations could be used as Indian reference equations for healthy children based on the SES. © 2005 Wiley‐Liss, Inc.
Identification of domains and domain interface residues in multidomain proteins from graph spectral method
Authors: Sistla Ramesh K. , K. V. Brinda , Vishveshwara Saraswathi 
Published: March 2005

AbstractWe present a novel method for the identification of structural domains and domain interface residues in proteins by graph spectral method. This method converts the three‐dimensional structure of the protein into a graph by using atomic coordinates from the PDB file. Domain definitions are obtained by constructing either a protein backbone graph or a protein side‐chain graph. The graph is constructed based on the interactions between amino acid residues in the three‐dimensional structure of the proteins. The spectral parameters of such a graph contain information regarding the domains and subdomains in the protein structure. This is based on the fact that the interactions among amino acids are higher within a domain than across domains. This is evident in the spectra of the protein backbone and the side‐chain graphs, thus differentiating the structural domains from one another. Further, residues that occur at the interface of two domains can also be easily identified from the spectra. This method is simple, elegant, and robust. Moreover, a single numeric computation yields both the domain definitions and the interface residues. Proteins 2005. © 2005 Wiley‐Liss, Inc.
A Novel Proton Transfer Compound Containing 2, 6‐Pyridinedicarboxylic Acid and Creatinine and its Zinc(II) Complex — Synthesis, Characterization, Crystal Structure, and Solution Studies
Authors: Moghimi Abolghasem , Sharif Mahboubeh A. , Shokrollahi Ardeshir , Shamsipur Mojtaba , Aghabozorg Hossein 
Published: March 2005

AbstractThe 1:1 proton transfer compound LH2, (creatH)+ (pydcH)−, has been prepared from the reaction of creatinine, creat, and dipicolinic acid, pydcH2, (2, 6‐ pyridinedicarboxylic acid) and characterized using IR, 1H and 13C NMR spectroscopy. The first coordination complex (creatH)[Zn(pydc)(pydcH)]·4H2O, was prepared using LH2 and zinc(II) nitrate, and characterized using IR, 1H and 13C NMR spectroscopy and single crystal X‐ray crystallography. The crystal system is triclinic with space group ${\rm P}_{\bar 1}$ with two molecules per unit cell. The unit cell dimensions are a = 8.085(2) Å, b = 10.802(4) Å, c = 13.632(4) Å, α = 104.98(2)°, β = 90.31(2)° and γ = 92.55(3)°. The structure has been refined to a final value for the crystallographic R factor of 0.0381 based on 3003 reflections. The zinc atom is six‐coordinated with a distorted octahedral geometry. The (pydc)2− and (pydcH)− units are almost perpendicular to each other. Extensive hydrogen bondings between carboxylate groups, (creatH)+ and water molecules throughout the zinc(II) complex as well as π–π stacking and ion pairing play important roles in stabilizing the corresponding lattices. The protonation constants of the building blocks of the pydcH2‐creat adduct, the equilibrium constants for the reaction of (pydc)2− with creat and the stoichiometry and stability of the ZnII complex with LH2 in aqueous solution were accomplished by potentiometric pH titration. The solution studies support a self‐associated (creatH)+(pydcH)− as the most abundant species at pH = 3.4. The stoichiometry of the crystalline complex (i.e. (creatH) [Zn(pydc)(pydcH)])and that of the most abundant species detected in solution were found the same.
Synthesis and Crystal Structure of Bis(tetraethylammonium) Octabromo‐triselenate(II)‐{dibromodiselenate(I)}, [NEt4]2[Se3Br8(Se2Br2)], the Salt of a Mixed‐valence Bromoselenate(II, I) Anion
Authors: Janickis Vitalijus , Milius Wolfgang , Törnroos Karl Wilhelm 
Published: March 2005

AbstractThe brown crystals of [NEt4]2[Se3Br8(Se2Br2)] (1) were obtained when selenium and bromine reacted in the solution of acetonitrile in the presence of tetraethylammonium bromide. The crystal structure of 1 has been determined by the X‐ray methods and refined to R = 0.0308 for 10433 reflections. The crystals are monoclinic, space group P21 with Z = 2 and a = 12.0393(3) Å, b = 11.8746(3) Å, c = 13.1946(3) Å, β = 96.561(1)° (123 K). In the solid state structure the anion of 1 is built up of Se3Br8 unit which consists of a triangular arrangement of three planar SeBr4 units sharing a common edge through two μ3‐bridging Br atoms, and one Se2Br2 molecule which is linked to one of μ3‐bridging Br atoms. The three SeII atoms form a triangle which is almost perpendicular to the planes given by three SeBr4 moieties. The contact between the μ3Br and the SeI atom of the Se2Br2 molecule is 3.1711(8) Å and can be interpreted as a bond of the donor‐acceptor type with the μ3Br as donor and the Se2Br2 molecule as acceptor. The terminal SeII‐Br and μ3Br‐SeII bond lengths are in the ranges 2.3537(7)–2.4737(7) Å and 2.7628(7)–3.1701(7) Å, respectively. The bond lengths in coordinated Se2Br2 molecule are: SeI‐SeI = 2.2636(9) Å, SeI‐Br = 2.3387(11) and 2.3936(8) Å.
Synthesis and Structures of Homoleptic Monomeric Potassium Aryloxolanthanoidate(III) Complexes
Authors: Deacon Glen B. , Gitlits Alex , Junk Peter C. , Skelton Brian W. , White Allan H. 
Published: March 2005

AbstractReaction of lanthanoid tris(2, 6‐diphenylphenolates) [Ln(Odpp)3] with KOdpp in 1, 2, 4, 5‐tetramethylbenzene (durene) at 200‐250 °C affords [K{Ln(OC6H3Ph2‐2, 6)4}], (Ln = La (1) or Nd (2)) and 2 has also been obtained from the reaction of [Nd(Odpp)3] with potassium hydride. In the solid state, 1 and 2 are monomeric bimetallics in which Ln is surrounded by a distorted tetrahedral array of oxygen atoms. Two Odpp ligands are oxygen bridged between K and Ln and also are η4‐Ph linked to potassium. One Odpp ligand bridges the metals in an O(Ln): η6‐Ph(K) manner that is new for lanthanoid complexes of this ligand, with no close K‐O contact, and the remaining Odpp is terminal on the Ln.
Die Kristallstrukturen von (DDI)2[Sb2F6O] und (DDI)2[Sb3F7O2] (DDI = 1, 3‐Diisopropyl‐4, 5‐dimethylimidazolium) — Ein Beitrag zur Hydrolyse von SbF3 [1]
Authors: Kuhn Norbert , Abu‐Rayyan Ahmed , Kolb Heinz‐Jürgen , Ströbele Markus 
Published: March 2005

AbstractThe Crystal Structures of (DDI)2[Sb2F6O] and (DDI)2[Sb3F7O2] (DDI = 1,3‐Diisopropyl‐4,5‐dimethylimidazolium) — a Contribution to the Hydrolysis of SbF3 [1]The salts (DDI)2[Sb2F6O] (2) and (DDI)2[Sb3F7O2] (3), (DDI = 1,3‐diisopropyl‐4,5‐dimethylimidazolium) are obtained by hydrolysis of C11H20N2SbF3 (1). The anion [Sb2F6O]2− consists of two SbF2 fragments linked by a symmetrical oxygen bridge and two unsymmetrical fluorine bridges to form a distored ψ‐octahedral coordination sphere at the antimony atoms. In [Sb3F7O2]2−, two SbF2 units are linked by a symmetrical fluorine bridge, while the third antimony atom is connected with each SbF2 fragment by a symmetrical oxygen and an unsymmetrical fluorine bridge. The antimony atoms adopt the centres of strongly distored ψ‐polyhedra.
Differences in Individual Approaches: Communication in the Familial Breast Cancer Consultation and the Effect on Patient Outcomes
Authors: Lobb Elizabeth A. , Butow Phyllis , Barratt Alexandra , Meiser Bettina , Tucker Katherine 
Published: March 2005

AbstractThis multicenter study aimed to assess (i) whether individual clinical geneticists and genetic counselors vary in their communication skills and (ii) whether this variation in communication impacts on patient outcomes, such as anxiety, depression, genetics knowledge, and satisfaction. One hundred and fifty women from high‐risk breast cancer families attending their first genetic counseling consultation completed pre and post‐consultation self‐report questionnaires. The consultations were audiotaped and transcribed verbatim. Univariate analyses showed highly significant differences between individual clinical geneticists and genetic counselors in: facilitating understanding (p ≤ 0.001); facilitating active involvement (p ≤ 0.001); facilitating partnership building (p = 0.003); addressing emotional concerns (p ≤ 0.001); and discussing prophylactic mastectomy (p = 0.017). Multivariate linear regressions showed that this variation in communication resulted in a greater change in patient's depression 4 weeks after the counseling session (p = 0.017). These findings suggest clinical geneticists and genetic counselors have achieved some standardization in communicating information, but showed diversity in their facilitation skills. Communication skills may be a useful area to explore further in this field.