bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mendelian randomization study on causal effects of inflammatory bowel disease on the risk of erectile dysfunction
Authors: Chen Di , Zhou Chao , Luo Quanhai , Chen Changsheng , Liu Gang 
Published: January 2024

AbstractThis study aimed to evaluate the causal effects of inflammatory bowel disease (IBD) and erectile dysfunction (ED) using Mendelian randomization (MR). All datasets were obtained from the public genome-wide association study database. In the exposure group, 12,882 IBD patients and 21,770 controls were included. A total of 1154 ED patients and 94,024 controls were included in the outcome group. Two-sample MR was conducted to estimate the causal effect of IBD on ED. Furthermore, Crohn's disease (CD) and ulcerative colitis (UC) were exposure factors in subgroup analyses. Weighted median, MR-egger, Inverse-variant weighted (IVW), weighted mode, and simple mode methods were used in MR analysis. Horizontal pleiotropy test, heterogeneity test, and leave-one-out method were utilized to evaluate the sensitivity and stability of results. After analysis, 62, 52, and 36 single nucleotide polymorphisms (SNPs) that IBD-ED, CD-ED, and UC-ED were included, respectively. The incidence of ED was increased by IBD (IVW: OR = 1.110, 95% CI = 1.017–1.211, P = 0.019; P-heterogeneity > 0.05) and, in addition, ED was affected by CD (IVW: OR = 1.085, 95% CI = 1.015–1.160, P = 0.016; P-heterogeneity > 0.05). However, there was no causal effect of UC on ED (IVW: OR = 1.018, 95% CI = 0.917–1.129, P = 0.743; P-heterogeneity < 0.05). All SNPs showed no significant horizontal pleiotropy (P > 0.05). These results indicate that IBD and CD can cause ED; However, UC did not cause ED. Additional research was required to determine causality and potential mechanisms further.
The population context is a driver of the heterogeneous response of epithelial cells to interferons
Authors: Metz-Zumaran Camila , Uckeley Zina M , Doldan Patricio , Muraca Francesco , Keser Yagmur , Lukas Pascal , Kuropka Benno , Küchenhoff Leonie , Rastgou Talemi Soheil , Höfer Thomas , Freund Christian , Cavalcanti-Adam Elisabetta Ada , Graw Frederik , Stanifer Megan , Boulant Steeve 
Published: January 2024

AbstractIsogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning approach combined with high-content imaging and spatial analyses, we characterized how the population context (position of a cell with respect to neighboring cells) of epithelial cells affects their response to interferons. We identified that cells at the edge of cellular colonies are more responsive than cells embedded within colonies. We determined that this spatial heterogeneity in interferon response resulted from the polarized basolateral interferon receptor distribution, making cells located in the center of cellular colonies less responsive to ectopic interferon stimulation. This was conserved across cell lines and primary cells originating from epithelial tissues. Importantly, cells embedded within cellular colonies were not protected from viral infection by apical interferon treatment, demonstrating that the population context-driven heterogeneous response to interferon influences the outcome of viral infection. Our data highlights that the behavior of isolated cells does not directly translate to their behavior in a population, placing the population context as one important factor influencing heterogeneity during interferon response in epithelial cells.
A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X
Authors: Jowhar Ziad , Xu Albert , Venkataramanan Srivats , Dossena Francesco , Hoye Mariah L , Silver Debra L , Floor Stephen N , Calviello Lorenzo 
Published: January 2024

AbstractThe road from transcription to protein synthesis is paved with many obstacles, allowing for several modes of post-transcriptional regulation of gene expression. A fundamental player in mRNA biology is DDX3X, an RNA binding protein that canonically regulates mRNA translation. By monitoring dynamics of mRNA abundance and translation following DDX3X depletion, we observe stabilization of translationally suppressed mRNAs. We use interpretable statistical learning models to uncover GC content in the coding sequence as the major feature underlying RNA stabilization. This result corroborates GC content-related mRNA regulation detectable in other studies, including hundreds of ENCODE datasets and recent work focusing on mRNA dynamics in the cell cycle. We provide further evidence for mRNA stabilization by detailed analysis of RNA-seq profiles in hundreds of samples, including a Ddx3x conditional knockout mouse model exhibiting cell cycle and neurogenesis defects. Our study identifies a ubiquitous feature underlying mRNA regulation and highlights the importance of quantifying multiple steps of the gene expression cascade, where RNA abundance and protein production are often uncoupled.
My Perspective: Auditory Evoked Potentials Using Speech
Authors: Cone Barbara 
Published: January 2024

Purpose:
The purpose of this tutorial is to clarify the use of speech sounds as stimuli for auditory evoked potentials and how these might contribute to our understanding of speech, language, learning, and hearing disorders. Speech-evoked auditory brainstem responses (ABRs), auditory steady-state responses, auditory middle latency responses, mismatch negativity, P300, cortical onset responses, and the acoustic change complex are reviewed.

Method:
The author drew upon her scholarship in this area from over 4 decades of research and teaching to summarize the major findings when using speech stimuli to evoke auditory potentials that have been used in clinical contexts.

Results:
Speech-evoked auditory potentials contribute to our understanding of how the brain processes the acoustic features of speech sounds, providing information that is complementary to psychophysical tests. When psychophysical tests cannot be performed owing to neurodevelopmental immaturity or disability, or cognitive disability, speech-evoked auditory potentials may be used to estimate the benefit of amplification or implantation for speech, language, and hearing.

Conclusions:
The benefit of using auditory evoked potentials for evaluation is that they provide insight into the brain mechanisms underlying hearing and listening disorders that audiologists aim to treat. While we can use the known correlations between perceptual and electrophysiological responses for “cross-checking” our evaluation results, examining when discrepancies occur is also especially meaningful. For example, the complex ABR reveals subcortical issues in temporal processing that would not be evident in ABRs to clicks or tone bursts, nor in behavioral testing. P300 can document slower neural processing of speech stimuli that may be relevant to the rehabilitation of older adults, even when word recognition scores appear to be congruent with the pure-tone audiogram. In these ways, auditory evoked potentials for speech provide audiologists with tools for demonstrating to clients how their brain responds to speech and opening the conversation for rehabilitation.
Analysis of the influence of large‐scale offshore wind power on the steady‐state voltage of the vicinity region of grid connection point
Authors: Gao Weilun , Wu Zhigang 
Published: January 2024

AbstractThe power characteristics of offshore wind power will change the regional power flow distribution and affect the regional voltage. Here, the direct‐drive wind turbine generator controlled by unity power factor is selected as the research object, and the influence of change of wind power on voltage at the grid connection point is analyzed from the simple integration model. Based on the two critical states of the external equivalent power of the grid connection point, an analytical expression of the output of wind power in the corresponding state is obtained, and the relationship among the critical state outputs, the output of wind power and the parameters at the grid connection point is drawn, hence the related influence laws is analyzed. The influence of change of wind power on voltage and regional reactive power and the reactance distribution of transmission lines near the grid connection point is considered to analyze the influence of offshore wind power on the vicinity region of grid connection point. The rationality of the conclusion is verified by study the cases of the integration of offshore wind power into Guangdong power grid, and some suggestions are put forward for the planning of offshore wind power integration.
A new technique for fault diagnosis in transformer insulating oil based on infrared spectroscopy measurements
Authors: Darwish Mohamed M. F. , Hassan Mohamed H. A. , Abdel‐Gawad Nagat M. K. , Lehtonen Matti , Mansour Diaa‐Eldin A. 
Published: January 2024

AbstractCondition monitoring of the insulating system within power transformers has a massive importance according to the electrical utilities. Dissolved gas analysis (DGA) is frequently used for this purpose. However, DGA lacks the necessary level of accuracy to identify all equipment faults, particularly in their initial stages of degradation. Also, it does not have the capability for real‐time monitoring and relies on manual sampling and laboratory testing, causing potential delays in fault identification. Additionally, the interpretation of DGA data necessitates specialised expertise, which may pose difficulties for smaller entities that have limited access to resources. Therefore, the contribution of this research is to use infrared spectroscopy measurements as a new effective technique substituting the DGA method for fault diagnosis in insulating oil. The inception faults that were considered in this study were the electrical fault (discharges of high energy) and the thermal fault (300°C < Temperature < 700°C). Regarding that, two test cells were crafted especially for serving the simulation processes inside the laboratory for both types of inception faults. Subsequently, six samples of pure paraffinic mineral oil were taken to be degraded in the laboratory. Following that, all of them besides another sample that were not subjected to any kind of faults were taken to be examined by Fourier transform infrared (FTIR) spectroscopy to obtain an overview of the oil's behaviour in each fault case. After that, the FTIR analysis was initially verified utilising the DGA method. Then, for further affirmation, the dielectric dissipation factor (DDF) for all samples was measured. In the final analysis, the verification tests provide experimental evidence about the outperformance of this new optical technique in detecting the transformer's inception faults in addition to proving its potential for being a superior alternative to the well‐known traditional diagnostic techniques.
Optimal siting and sizing of custom power system and smart parking lot in the active distribution network
Authors: Ebrahimi Ahad , Moradlou Majid , Bigdeli Mehdi 
Published: January 2024

AbstractNon‐linear loads, electrical vehicles (EVs) and power electronics are the sources of harmonic generation in the power system. Harmonics are the reason for the disturbance in the technical constraints and quality of the power system. These disadvantages are formed in the current and the voltage of the system branches and buses. To reduce these harmonics, active and passive power filters are used. Since active power filters (APFs) include electronic power switching devices, they are used to eliminate or reduce current or voltage harmonics. To properly reduce these harmonics and supply consumer demand, private investors (PIs) are considered to enhance the power quality, by investing in the APF units and the distribution network operator (DNO) coordinating and feeding the EVs, by equipping the network with smart parking lots. Total harmonic distortion, bus voltage profile, active power loss and energy not supplied (ENS) are considered problem attributes. Using techniques for order of preference by similarity to the ideal solution (TOPSIS), it is determined how the addition of photovoltaic (PV), energy storage system, and batteries affects the ranking of attributes from the perspectives of both DNO and PI. The best solutions are obtained in the first stage using a genetic algorithm (GA), and the attributes have been prioritized from a utility perspective in the second stage by TOPSIS. To verify the performance of GA and TOPSIS, all of the obtained results are compared with the other algorithms. As seen clearly, active, reactive power loss and ENS in scenarios with the participation PV are reduced. Furthermore, comparing the results of different algorithms confirms the efficiency of GA and TOPSIS.
Impact of discontinuous grain size distributions on the spectral energy distribution of debris disks
Authors: Kim M. , Wolf S. 
Published: January 2024

Context. The collisional evolution of debris disks is expected to cause the characteristic wavy pattern, that is, an under- or overabundance of particles of specific sizes, of grain size distributions. This perturbed grain size distribution potentially leaves characteristic patterns in the spectral energy distribution (SED) of the disk system.
Aims. We aim to quantify and understand the specific influence of discontinuous particle size distributions on the appearance of debris disks. For this purpose, we considered dust emission models based on two different grain size distributions, namely, one with a single power law and one with a broken power law. In particular, our study is focused on the impact of an overabundance of small grains and an underabundance of medium-sized grains on the far-IR and (sub-)millimeter regime on the dust reemission radiation and the potential to constrain discontinuities in the grain size distribution from (sub-)millimeter photometric measurements of debris disks.
Methods. We compared the spectral index α (Fν ∝ να) in the case of a continuous grain size distribution with that of a discontinuous grain size distribution. We performed this comparison for central stars with different spectral types and two different disk structures (e.g., slim and broad debris dust rings).
Results. Within the considered parameter space, we found a characteristic difference between the spectral slopes of the SED in the different scenarios. In particular, the overabundance of small grains resulting from collisional events and thus parameters defining the outcome of disk events in debris disks is potentially observable by comparison with the SED corresponding to a grain size distribution resulting from an ideal collisional cascade. More specifically, the overabundance of small grains leads to a steeper slope in the far-IR and sub-millimeter regime, while the spectral index in the millimeter regime is hardly affected. On the other hand, the underabundance of medium-sized grains results in a slight steepening of the far-IR slope of the SED, but its primary effect is on the millimeter slope of the SED, causing it to become shallower. We also found that the impact of an overabundance of small dust particles is more pronounced than that of an underabundance of medium-sized dust particles. We also found that the difference between the spectral indices for the two different grain size distributions is largest for debris disks around brighter central stars and broader disks. However, the impact of the considered spatial distributions described by the fractional width of the disk system is weak. Our results also show that the dust composition is not the sole physical mechanism responsible for the spectral inversion observed in the far-IR to millimeter part of the SED of debris disk systems. Furthermore, the location of the spectral break is placed at different wavelength regimes if the grain size distribution is considered as a function of blowout size and stellar type.
Characterisation of the stellar activity of M dwarfs
Authors: Meunier N. , Mignon L. , Kretzschmar M. , Delfosse X. 
Published: January 2024

Context. The chromospheric emission estimated in the core of different lines, such as Ca II H & K, Na D1 and D2, and Ha, is not always correlated between lines. In particular, the Ca II H & K and Ha emission time series are anti-correlated for a few percent of the stars, contrary to what is observed on the Sun. This puzzling result has been observed for both solar-type stars and M stars.
Aims. Our objective is to characterise these relationships in more detail using complementary criteria, and based on a large set of spectra obtained with HARPS for a large sample of M dwarfs. This should allow to evaluate whether or not additional processes are required to explain the observations.
Methods. We analysed the time average and variability of the Ca, Na, and Hα emissions for 177 M stars ranging from subspectral types M0 to M8, paying particular attention to their (anti-)correlations on both short and long timescales as well as slopes between indices. We also computed synthetic Hα time series based on different assumptions of plage properties. We compared our findings with observations in order to evaluate whether or not the main observed properties could be reproduced.
Results. The statistical properties of our sample, in terms of correlations and slopes between indices at different timescales, differ from what we previously obtained for FGK stars: there are fewer stars with a null correlation, and the correlations we find show a weaker dependence on timescale. However, there can be a large dispersion from one season to another for stars with a well identified low or negative correlation. We also specify the complex relationship between the average activity levels, with a clear indication of a change in the sign of the slope from the relation between Ca and Hα (and between Na and Ha) for the most massive M dwarfs. In addition, we observe a change in slope in the Na–Ca relation at an intermediate activity level. At this stage, we are not able to find simple plage properties that, alone, are sufficient to reproduce the observations. However, the simulations already allow us to point out that it is not straightforward to compare the temporal variability correlation and the integrated indices. Our findings also demonstrate the need for complex activity patterns to explain some of the observations.
Conclusions. We conclude that the relation between the three indices examined here exhibits a large diversity in behaviour over the sample studied. More detailed simulations with complex activity patterns are necessary to understand these observations. This will teach us about plage properties for this type of star.
Optimising spectroscopic observations of transiting exoplanets
Authors: Boldt-Christmas Linn , Lesjak Fabio , Wehrhahn Ansgar , Piskunov Nikolai , Rains Adam D. , Nortmann Lisa , Kochukhov Oleg 
Published: January 2024

Context.When observing the atmospheres of transiting exoplanets using high-resolution spectroscopy, the aim is to detect well-resolved spectral features with high signal-to-noise ratios (S/Ns), as is possible today with modern spectrographs. However, obtaining such high-quality observations comes with a trade-off: a lower cadence of fewer, longer exposures across the transit collects more photons thanks to reduced overheads, enhancing the S/N of each observation, while a higher cadence of several shorter exposures minimises spectral feature smearing due to the continuously changing radial velocity of the planet.Aims.Considering that maximising S/N and minimising smearing are both beneficial to analysis, there is a need to identify the optimal compromise between the two for a given target. In this work, we aim to establish where this compromise lies for a typical exoplanet transit observation in order to benefit future data collection and subsequent interpretation.Methods.We modelled real transit events based on targets as they would be observed with VLT/CRIRES+ at Paranal Observatory, Chile. Creating four hypothetical scenarios, we simulated each set of transmission spectra across 100 realisations of the same transit event in order to vary the time resolution only. We removed telluric and stellar lines from these data sets using the SYSREM algorithm and analysed them through cross-correlation with model templates, measuring how successfully each time resolution and case detected the planetary signal and exploring how the results vary.Results.We demonstrate that there is a continuous change in the significance of the cross-correlation detection based on the trade-off between high and low time resolutions, and that, averaged over a large number of realisations, the function of this significance has clear maxima. The strength and location of these maxima vary depending on, for example, planet system parameters, instrumentation, and the number of removal iterations. We discuss why observers should therefore take several factors into account using a strategy akin to the ‘exposure triangle’ employed in traditional photography where a balance must be struck by considering the full context of the observation. Our method is robust and may be employed by observers to estimate the best observational strategies for other targets.
Probing the interstellar medium of the quasar BRI 0952−0115
Authors: Kade K. , Knudsen K. K. , Bewketu Belete A. , Yang C. , König S. , Stanley F. , Scholtz J. 
Published: January 2024

Context. The extent of the effect of active galactic nuclei (AGN) on their host galaxies at high-redshift is not apparent. The processes governing the co-eval evolution of the stellar mass and the mass of the central supermassive black hole, along with the effects of the supermassive black hole on the host galaxy, remain unclear. Studying this effect in the distant universe is a difficult process as the mechanisms of tracing AGN activity can often be inaccurately associated with intense star formation and vice versa.
Aims. Our aim is to better understand the processes governing the interstellar medium (ISM) of the quasar BRI 0952−0952 at z = 4.432, specifically with regard to the individual heating processes at work and to place the quasar in an evolutionary context.
Methods. We analyzed ALMA archival bands 3, 4, and 6 data and combined the results with high-resolution band-7 ALMA observations of the quasar. We detected [C I](2–1), [C II](2P3/2 − 2P1/2), CO(5–4), CO(7–6), CO(12–11), OH 2Π1/2(3/2 − 1/2), and H2O(211 − 202), and we report a tentative detection of OH+. We updated the lensing model and we used the radiative transfer code MOLPOP-CEP to produce line emission models which we compared with our observations.
Results. We used the [C I] line emission to estimate the total molecular gas mass in the quasar. We present results from the radiative transfer code MOLPOP-CEP constraining the properties of the CO emission and suggest different possible scenarios for heating mechanisms within the quasar. We extended our results from MOLPOP-CEP to the additional line species detected in the quasar to place stronger constraints on the ISM properties.
Conclusions. Modeling from the CO SLED suggests that there are extreme heating mechanisms operating within the quasar in the form of star formation or AGN activity; however, with the current data, it remains unclear which of the two is the preferred mechanism as both models reasonably reproduce the observed CO line fluxes. The updated lensing model suggests a velocity gradient across the [C II] line, suggestive of ongoing kinematical processes within the quasar. We find that the H2O emission in BRI 0952 is likely correlated with star-forming regions of the ISM. We used the molecular gas mass from [C I] to calculate a depletion time for the quasar. We conclude that BRI 0952−0952 is a quasar with a significant AGN contribution while also showing signs of extreme starburst activity, indicating that the quasar could be in a transitional phase between a starburst-dominated stage and an AGN-dominated stage.