bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report
Authors: Jiang Xuejun , Ji Zujin , Li Peng , Yuan Fangjun , Lei Xinyi , Yang Yong 
Published: January 2025

BackgroundAnorectal malignant melanoma is a rare subtype of melanoma with a poor prognosis. Despite this, some patients decline Miles’ operation due to the sigmoid colostomies that follow abdominoperineal resections in cases of anorectal malignant melanoma.Case reportWe report the case of an 80-year-old woman diagnosed with anorectal malignant melanoma who underwent cryosurgery accompanied by adjuvant PD-1 therapy to maintain anal sphincter function. The results indicated that we successfully achieved the goal of sphincter preservation and therapeutic efficacy. The patient derived significant benefits from the cryoablation treatment.ConclusionsUltrasound-guided trans-anal cryoablation, when combined with adjuvant PD-1 therapy, offers a novel treatment approach for patients with anorectal malignant melanoma. Our results have confirmed the advantages of this treatment regimen, particularly for those desiring to retain anal sphincter function. Further studies are required to substantiate the efficacy of ultrasound-guided trans-anal cryoablation with adjuvant Toripalimab and to elucidate its underlying mechanisms.
Lowering light intensity while extending photoperiod at a constant daily light integral synergistically interacts with warm temperature to enhance leaf expansion and crop yield in lettuce in the absence of far-red light
Authors: Jeong Sang Jun , Zhen Shuyang , Zhang Qianwen , Niu Genhua 
Published: January 2025

IntroductionLow light intensity and far-red (FR) light act as shade signals to induce specific morphological changes mediated by plant photoreceptors phytochromes (PHYs). Applying FR light or lowering light intensity over a longer photoperiod at a constant daily light integral (DLI) can increase crop yield by enhancing leaf expansion and photon capture. However, PHY activity is also dependent on temperature. We aimed to investigate the interactive effects of FR light, light intensity, photoperiod, and temperature on plant growth and morphology.MethodsLettuce (Lactuca sativa L.) ‘Rex’ was grown under three temperatures (20, 24, and 28 °C), each containing six light treatments [two levels of FR light (0 and 20% FR in total photon flux density from 400-800 nm) x three light intensities (150, 200, and 300 μmol m-2 s-1)]. As light intensity increased, photoperiod was reduced (150, 200, and 300 μmol m-2 s-1 with photoperiods of 24 h, 18 h, and 12 h, respectively) to maintain a constant DLI of 13 mol m-2 d-1.ResultsUnder 0% FR light, the combination of lower light intensity/longer photoperiod and warmer temperature synergistically enhanced leaf expansion and photon capture; however, this interactive effect disappeared under 20% FR light. Stem elongation exhibited an opposite response pattern to leaf expansion; lower light intensity and warm temperature had a synergistic enhancement on stem elongation under 20% FR light, but not under 0% FR light. Shoot dry weight responded to the light and temperature factors similarly to total leaf area. Our results showed that plant biomass accumulation depended primarily on photon capture (r2 = 0.93), rather than single-leaf photosynthetic efficiency. Antioxidant capacity was generally reduced by lower light intensity and FR light, but the reduction could be compensated by warmer temperatures.DiscussionThus, we concluded that applying lower light intensity over a longer photoperiod, combined with warm temperature, can effectively maximize leaf expansion and crop yield while maintaining nutritional quality in the absence of FR light. However, under strong shade signals composed of FR light, low light intensity, and warm temperature, lettuce prioritizes stem elongation at the expense of leaf expansion, leading to reduced crop yield.
The challenge of a late diagnosis of Autism Spectrum Disorder: co-occurring trajectories and camouflage tendencies. a case report of a young Autistic female with Avoidant Restrictive Food Intake Disorder
Authors: Passarini Sara , Guerrera Silvia , Picilli Maria , Fucà Elisa , Casula Laura , Menghini Deny , Pirchio Sabine , Zanna Valeria , Valeri Giovanni , Vicari Stefano 
Published: January 2025

IntroductionAutistic individuals may show several psychiatric co-occurrences, including Feeding and Eating Disorders (FEDs). Avoidant and Restrictive Food Intake Disorder (ARFID) consists of avoidance or restriction in food intake, leading to significant weight loss, nutritional deficiencies, and marked interference with psychosocial functioning. Both Autism Spectrum Disorder (ASD) and ARFID are characterized by the two main features of cognitive rigidity and sensory sensitivity, which may complicate differential diagnosis. There is a notable lack of information on the manifestation of ASD-ARFID co-occurrence, as well as tailored assessment tools and practice, and therapeutic approaches.Case descriptionThis report provides a detailed description of L., a young girl with a late diagnosis of ASD who also developed unspecific depressive mood disorder and ARFID in co-occurrence. After the diagnosis of ASD, L. underwent multiple evaluations to address emerging psychiatric co-occurrences and symptom exacerbation, and in order to develop the most effective integrated treatment.ConclusionThe case of L. expands the knowledge on the phenotype of Autistic females and exemplifies how delayed diagnosis may exacerbate functioning differences and increase the camouflage phenomenon. Additionally, it underscores the importance of improving tailored evaluation, combined treatment plans, with both cognitive-behavioral therapy and drugs, and monitoring the evolving patterns of Autistic manifestations and associated psychiatric co-occurrences.
Prevalence and determinants of HIV among reproductive-age women (15–49 years) in Africa from 2010 to 2019: a multilevel analysis of demographic and health survey data
Authors: Gedefie Alemu , Muche Amare , Mohammed Anissa , Ayres Aznamariam , Melak Dagnachew , Abeje Eyob Tilahun , Bayou Fekade Demeke , Belege Getaneh Fekadeselassie , Asmare Lakew , Endawkie Abel 
Published: January 2025

BackgroundHuman immunodeficiency virus (HIV) remains the leading cause of global morbidity and mortality. The incidence of HIV is disproportionately higher in Sub-Saharan regions, particularly the Southern African sub-region, which is the most affected region and accounts for 77% of all new HIV infections in the region. Thus, the aim of this study was to identify the determinants of HIV among reproductive-age women in Africa.MethodsThis study was conducted among reproductive-age women in Africa, based on secondary data obtained from the Demographic Health Survey (DHS) conducted between 2010 and 2019. The outcome variable was HIV status, while individual- and community-level variables served as potential predictors. The model fit was assessed using Akaike’s Information Criterion, Bayesian Information Criterion, and − 2 Log likelihood. Then, multilevel mixed-effects analysis was used. Intra-cluster correlation coefficient, median odds ratio, and proportional change in variance were used to measure heterogeneity between clusters.ResultsA total of 292,810 unweighted and 293,773 weighted reproductive-age women in 26 African nations were included in this study. The overall prevalence of HIV among reproductive-age women in Africa was 4.34% (95% CI: 4.2, 4.4%). The highest percentage of HIV was found in Lesotho (23.98%), followed by South Africa (19.12%), and Mozambique (14.67%). However, the lowest HIV prevalence was found in Niger (0.54%), Senegal (0.59%), and Burundi (0.79%). Southern Africa has the highest HIV burden (18.5%), followed by Eastern Africa (6.1%), while Western African countries have the lowest HIV burden. Increasing maternal age, higher maternal education, women who were unemployed, a history of multiple sexual partners, women in a union, community-level educational status, community-level wealth index, African sub-region, and urban residence were found to be independent predictors of HIV infection in Africa.ConclusionThe burden of HIV has remained higher, highlighting the need for targeted public health intervention strategies to prevent the transmission of HIV among key populations.
The prolonged health sequelae “of the COVID-19 pandemic” in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Alie Melsew Setegn , Tesema Getayeneh Antehunegn , Abebe Gossa Fetene , Girma Desalegn 
Published: January 2025

BackgroundSurvivors of coronavirus disease 2019 (COVID-19) often face persistent and significant challenges that affect their physical, mental, and financial wellbeing, which can significantly diminish their overall quality of life. The emergence of new symptoms or the persistence of existing ones after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis has given rise to a complex clinical issue known as “long COVID-19” (LC). This situation has placed additional strain on global healthcare systems, underscoring the urgent need for ongoing clinical management of these patients. While numerous studies have been conducted on the long-term effects of COVID-19, our systematic review, and meta-analysis, is the first of its kind in sub-Saharan Africa, providing a comprehensive understanding of the situation in the region and highlighting the necessity for continuous clinical management.ObjectiveThis study aimed to systematically synthesize evidence on the persistent sequelae of COVID-19 and their predictors in sub-Saharan Africa.MethodsA thorough search was conducted across multiple databases, including PubMed/MEDLINE, Web of Science, Google/Google Scholar, African online journals, and selected reference lists, from the inception of these databases until January 12, 2024. A meta-analysis of proportions was conducted using the random-effects restricted maximum-likelihood model. The association between various factors was also analyzed to determine the pooled factors that influence long COVID-19 outcomes.ResultsOur comprehensive analysis of 16 research articles, involving a total of 18,104 participants revealed a pooled prevalence of COVID-19 sequelae at 42.1% (95% CI: 29.9–55.4). The long-term health sequelae identified in this review included persistent pulmonary sequelae (27.5%), sleep disturbance (22.5%), brain fog (27.4%), fatigue (17.4%), anxiety (22.3%), and chest pain (13.2%). We also found a significant association was observed between comorbidities and long COVID-19 sequelae [POR = 4.34 (95% CI: 1.28–14.72)], providing a comprehensive understanding of the factors influencing long COVID-19 outcomes.ConclusionCOVID-19 can have long-lasting effects on various organ systems, even after a person has recovered from the infection. These effects can include brain fog, pulmonary symptoms, sleep disturbances, anxiety, fatigue, and other neurological, psychiatric, respiratory, cardiovascular, and general symptoms. It is crucial for individuals who have recovered from COVID-19 to receive careful follow-up care to assess and reduce any potential organ damage and maintain their quality of life.Systematic review registrationClinicaltrial.gov, identifier CRD42024501158.
Gender stereotypes and professional experiences of female nurses in Türkiye
Authors: Aca Zeynep , Kırcal-Şahin Arzu , Özdemir Akın , Kaymakcı Yavuz Selim 
Published: January 2025

IntroductionGender roles and stereotypes play a significant role in shaping the nursing profession, perpetuating systemic inequities that negatively impact professional experiences and healthcare system efficiency. In Türkiye, patriarchal norms and systemic disparities exacerbate these workplace challenges, particularly for female nurses.MethodsThis qualitative study utilized semi-structured interviews with 13 female nurses working in intensive care units to examine the influence of societal expectations, workplace discrimination, and institutional policies on gender inequities in nursing.ResultsThe findings reveal that cultural norms, family influence, and constrained career planning often channel women into nursing, reinforcing perceptions of the profession as an extension of caregiving roles. While participants rejected the notion of nursing as a “women’s profession,” their narratives highlighted the pervasive impact of gendered expectations. Additionally, political favoritism and nepotism were identified as factors exacerbating workplace challenges, reflecting broader systemic issues in Türkiye’s labor market. The normalization of gender norms and their internalization by female nurses further complicate efforts to combat discrimination.DiscussionThe study underscores the necessity for policy interventions to address systemic gender inequities in nursing. Recommendations include implementing mandatory gender equality education within healthcare institutions, stricter enforcement of anti-violence laws, and the establishment of psychological and legal support systems for workplace violence victims. Additional measures, such as childcare support and regulations against marital status-based discrimination, are essential to mitigate inequities. By addressing societal, cultural, and institutional factors, this research provides actionable strategies for healthcare organizations and policymakers to promote equity and improve sector efficiency.
Impact of COVID-19 pandemic restrictions and relaxation on pediatric respiratory virus hospitalizations in Southwest China: a retrospective study
Authors: Gong Ting , He Fengqi , Zhao Yongle , Lu Shuya , Tian Daiyin 
Published: January 2025

BackgroundResearch from multiple regions indicates that Coronavirus disease of 2019 (COVID-19) pandemic has altered the epidemiological characteristics of respiratory viruses.MethodsThis single-center retrospective study included children hospitalized for lower respiratory tract infections (LRTIs) from 2017 to mid-2024. Data on respiratory syncytial virus (RSV), adenovirus (ADV), influenza A virus (IAV), influenza B virus (IBV), and parainfluenza virus (PIV)—were collected and analyzed across pre-pandemic, pandemic, and post-pandemic periods.ResultsA total of 59173 children were included. Detection rates were 34.97% (8553/24459) pre-pandemic, 21.93% (4621/21067) during the pandemic, and 21.64% (2953/13647) post-pandemic. Mixed infections rates significantly decreased during the pandemic (0.78%) and post-pandemic (0.78%) compared to pre-pandemic levels (1.63%) (P &lt; 0.001). RSV was the most prevalent virus across all periods (P &lt; 0.001). Following non-pharmaceutical interventions (NPIs) in 2020, detection rates declined significantly. After restrictions eased in 2021, RSV, PIV, and IBV surged, while IAV continued to decline until its resurgence in spring 2023 (P &lt; 0.001). Certain viruses showed altered seasonal patterns: during the spring and summer of 2021, RSV detection rates exceeded those of previous years, while the expected winter 2022 peak was delayed by approximately six months. IAV peaks disappeared during winters of 2020 and 2021, peaking in spring 2023. IBV peaked in autumn 2021 and winter 2023. PIV had an unusual rise in summer 2020, peaking in autumn, delayed by about five months. The peak in the first half of 2024 returned to its normal timing. ADV appeared to be unaffected, with increased detection in 2022, and decreased in 2023 and 2024.ConclusionEpidemiological patterns of respiratory viruses have been altered by multiple influencing factors. The significance of vaccination, hygiene practices, public health interventions and etc. was emphasized in addressing pandemics. Additionally, ongoing dynamic monitoring is essential due to the evolving epidemiology.
Анализ финансового положения предприятия:практический аспект
Authors: Маккаева Р.С. , Хаджимурадов А.О. , Гериханова Л.М. 
Published: January 2025

В данной статье показан анализ финансового состояния организации, указываются факторы, влияющие на финансовоэкономическое положение предприятия, атакже рассматривается методика проведения финансового анализа предприятия. Актуальность исследуемой темы определена ценностью финансового климата любой организации. Целью исследования является точная оценкафинансового состоянияорганизации. Результатыанализапомогают выделить слабые места предприятия.
This article is devoted to the topic of analysis of the financial condition of the organization. The article identifies factors that affect the financial and economic situation of the company, as well as the methodology of conducting a financial analysis of the company. The relevance of the problem under study is due to the value of the financial climate of any organization. The purpose of the article is to correct assessments of the financial condition of the organization. The results of the analysis help to highlight the weaknesses of the enterprise.
Аудиторская проверка в сфере торговой деятельности
Authors: Исраилова З.Р. , Мациева М.Л.-А. 
Published: January 2025

в данной статье изучены особенности аудиторской проверки деятельности предприятий торговой сферы, акцентировано внимание на аудиторской проверки кассы, раскрыта процедура ее проверки, а также даны схематично ошибки, наиболее часто выявляемые в ходе аудита в торговой сфере. Аудиторская проверка торговых мероприятий на предприятиях торговой сферы обладает своими особенностями. Кроме неотъемлемых аудируемых документов перечень вписываются вспомогательные ведомости, к примеру: о запасах товаров, товарообороте и других показателей. Названные стороны аудита в торговой сфере и отражают актуальность исследования.
this article examines the features of the audit of the enterprises of the trade sector, focuses on the audit of the cash register, discloses the procedure for checking it, and also gives schematic errors that are most often detected during the audit in the trade sphere. The audit of trade events at trade enterprises has its own peculiarities. In addition to the essential audited documents, the list includes auxiliary statements, for example: on stocks of goods, turnover and other indicators. These parties to the audit of the trade and reflect the relevance of the study.
Некоторые особенности аудита в строительных организациях
Authors: Цадаева Х.С. , Исраилова З.Р. 
Published: January 2025

в настоящей статье изучена специфика проведения аудиторской проверки в строительных организациях и ее роль в оценке качества деятельности, а также трудовых нагрузок подряда.
This article discusses the specifics of the audit in construction organizations and its role in assessing the quality of activities and workloads under the contract.
Финансовые ресурсы организации: источники формирования иэффективность использования
Authors: Гурфова С.А. 
Published: January 2025

Финансовая стабильность любого предприятия (организации), которая необходима в рыночной экономике для достижения максимального и перманентного успеха, в значительной мере определяется наличием финансовых ресурсов в соответствующих объемах. Поэтому изучение вопросов, связанных с формированием и использованием финансовых ресурсов, управлением ими имеет вообще непреходящий характер. В статье анализируются источники формирования и оценивается с помощью финансовых показателей эффективность использования финансовых ресурсов конкретного предприятия. Даны рекомендации для повышения финансовой устойчивости и платежеспособности, а также улучшения финансового положения предприятия.
The financial stability of any enterprise (organization), which is necessary in a market economy to achieve maximum and permanent success, is largely determined by the availability of financial resources in appropriate volumes. Therefore, the study of issues related to the formation and use of financial resources, their management is generally enduring. The article analyzes the sources of formation and evaluates using financial indicators the effectiveness of the use of financial resources of a particular enterprise. Recommendations are given to increase financial stability and solvency, as well as improve the financial situation of the enterprise.
Факторы экономической устойчивости предприятия
Authors: Бабаева З.Ш. 
Published: January 2025

Под экономической устойчивостью предприятия понимается способность предприятия как экономической системы противостоять неблагоприятным воздействиям внешней среды и обеспечить равновесное развитие предприятия за счет оптимальной организации управления финансовыми и производственными ресурсами хозяйствующего субъекта. Основные факторы, влияющие на экономическую устойчивость промышленного предприятия, связаны с формированием финансовых ресурсов, эффективным использованием производственных ресурсов и рационализацией организации менеджмента на предприятии.
Under the economic stability of the enterprise is understood the ability of the enterprise as an economic system to withstand the adverse effects of the external environment and to ensure the equilibrium development of the enterprise due to the optimal organization of managing the financial and production resources of the economic entity. The main factors affecting the economic sustainability of an industrial enterprise are associated with the formation of financial resources, efficient use of production resources and rationalization of the organization of management at the enterprise.
Особенности воссоздания структурного анализа эпитета в эпосе «Манас»
Authors: Алишова М.К. 
Published: January 2025

Цель в настоящей статье являются структурные особенности эпитетов в эпосе Манас и в дальнейшем найти способы их воссоздание при переводе на неродственный язык. Произведения искусства в исследовании комплекса, синтетического лечения в течение длительного времени доминирующего аспекта лингвистики, учитывая уровень следствия ликвидировано. В рамках структурного анализа текст лингвистического произведения искусства не случайно, что взаимодействие подразделений, показало, что целевой характер работы: структура языка (языковые паттерны) для полного и эффективного осуществления концепции эстетического отражения автора. В исследовании комплекса, синтетического лечения в течение длительного времени доминирующего аспекта лингвистики, учитывая уровень следствия ликвидировано.
The purpose in this article is the structural features of the epithets in the epic Manas and to further find ways to recreate them when translated into an unrelated language. Works of art in the study of the complex, synthetic treatment for a long time the dominant aspect of linguistics, given the level of investigation eliminated. In the framework of structural analysis, the text of a linguistic work of art is not accidental that the interaction of the units showed that the purpose of the work: the structure of the language (language patterns) for the full and effective implementation of the concept of aesthetic reflection of the author. In the study of the complex, a synthetic treatment for a long time of the dominant aspect of linguistics, given the level of investigation eliminated.
Специфика стратегии инновационного развития России
Authors: Максименкова А.А. 
Published: January 2025

В статье обосновываются основные моменты создания стратегии инновационного развития Российской Федерации. В ходе проведенного исследования удалось определить, что важнейшей составляющей внутреннего механизма инновационного развития страны должна стать организация системы внутрихозяйственного планирования.
The article substantiates the main points of creating a strategy for innovative development of the Russian Federation. In the course of the study, it was possible to determine that the organization of the on-farm planning system should become the most important component of the internal mechanism of innovative development of the country