bluuebunny/crossref_metadata_2025_split huggingface dataset:
YouTube as a Source of Information for Pressure Injury: Quality Assessment and Content Analysis
Authors: Bang Myeonghwan , Jang Chan Woong , Cho Han Eol , Kim Hyoung Seop 
Published: October 2023

Abstract
Objective
We aimed to assess the quality and reliability of pressure injury-related videos uploaded on YouTube, analyze the sources and contents, and examine the correlation between video parameters.
Methods
We searched YouTube using two keywords, "pressure ulcer" and "pressure sore", on August 20, 2022. The quality of videos was assessed using the Global Quality Scale (GQS), while their reliability was evaluated by the modified DISCERN (mDISCERN) tool. In addition, we evaluated the videos in which content (risk factors, assessment, prevention, treatment) was included. Furthermore, we analyzed the correlation between GQS, mDISCERN, and video parameters and whether there were any differences in GQS, mDISCERN, and video parameters based on the sources that provided the videos.
Results
We initially found a total of 100 videos for each keyword and finally included and analyzed 77 videos. The mean scores for the mDISCERN and GQS were 2.35 ± 0.98 and 3.09 ± 0.99, respectively. Both GQS and mDISCERN showed statistically significant correlations with each other (rho = 0.54, p < 0.001*) and with the length of the videos, respectively (rho = 0.36, p < 0.01*), (rho = 0.29, p < 0.05*). Of the videos created by physicians, 8 (57.1%) included content related to treatment, while of the videos created by nonphysician health personnel, 22 (57.9%) included content related to prevention. Analyzing whether there were differences in video parameters based on the sources, we observed significant differences between sources in GQS (p < 0.001*), mDISCERN (p < 0.001*), and video length (p = 0.001*). In the post hoc analysis, videos uploaded by physicians or nonphysician health personnel showed higher quality and reliability than videos uploaded by other sources.
Conclusions
YouTube videos provide information on pressure injury and exhibit significant heterogeneity in terms of quality, reliability, and content composition. Therefore, the results of this study can be useful for healthcare providers, as well as patients and caregivers, to search for high-quality and reliable videos on YouTube.
Evaluating the effectiveness of the BeHealthyR study: A group-randomized controlled trial using an integrated approach to improve smoking cessation behavior among disadvantaged smokers
Authors: Shagiwal Sara , Schop-Etman Astrid , Merkelbach Inge , Kocken Paul , Denktas Semiha 
Published: October 2023

Abstract

BackgroundSmokers with a low socioeconomic position (SEP) often experience heightened stress due to increased exposure to daily hassles and multiple environmental, social, and smoking-specific stressors. In turn, these stressors may deplete mental bandwidth and trigger unhealthy behavioral responses, such as smoking. This study aimed to evaluate the effectiveness of an integrated multicomponent intervention developed to concurrently target stress- and smoking-related behaviors among socioeconomically disadvantaged smokers.MethodsA 3-group randomized controlled trial was conducted between February 2018 and July 2019. Adult low-SEP smokers experiencing stress complaints were recruited from disadvantaged neighborhoods in Rotterdam. Groups of participants were randomly assigned to a stress management course (SM, n = 62), stress management with a buddy component (SMb, n = 66) or a waitlist (n = 90). The SM and SMb groups received psychoeducation topics linked to cognitive and behavioral technique activities. SMb additionally provided emotional and instrumental support. The waitlist group received the intervention after the study. Groups were randomized using a computer-generated random allocation. Participants were blinded to the study hypotheses, while the research team was unblinded to allocation. Primary outcomes were assessed at baseline (T0), at week four of the intervention (T1) and at 12 weeks (T2), and included total stress scores, nicotine dependence scores, self-reported and expired carbon monoxide (eCO)-validated smoking abstinence at T1 and T2. The analyses were intention-to-treat and adjusted for covariates measured at baseline. Intervention effectiveness was examined using mixed-effects models.ResultsOf 209 participants (mean age, 47.1 (SD = 11.3, range 21–78 years), 176 completed the intervention (retention rate 84%). A significant reduction in stress levels was found in the SM at one month and in the SMb at three months compared to the waitlist. At one month and three months, nicotine dependence scores were significantly lower in the SM and SMb groups than in the waitlist group. No significant changes were observed in expired carbon monoxide levels.ConclusionsThese findings show that a multicomponent intervention aimed at relieving stress complaints may be a solution to improve smoking-related outcomes among socioeconomically disadvantaged smokers. These findings have implications and merit further evaluation. Trial registration: www.clinicaltrials.gov; identifier: NCT03553979; date of registration: 01/01/2018
Measurements of traditional Chinese medicine health literacy regarding chronic pain: A scoping review
Authors: Qian Zhiyi , Wang Grace , Henning Marcus , Chen Yan 
Published: October 2023

Abstract

Chronic pain is a prevalent health condition that imposes a significant burden on the global health system. Health literacy is a determinant of the quality of pain management which directly impacts public and individual health. However, the existing health literacy measurements have predominantly focused on medical models stemmed from Western culture and the knowledge of Indigenous and other non-Western health models has largely been neglected. This review scopes refereed health literacy publications with regards to traditional Chinese medicine and chronic pain to explore and identify 1) the conceptual basis underlying the development of Traditional Chinese medicine health literacy (TCM-HL) in this area, and 2) measurement tools used in this area and their associated psychometric qualities. Twenty-eight were assessed and the results showed that most studies’ conceptual basis was unable to cover three key health literacy aspects defined by the World Health Organization (access, understand, and apply). Furthermore, the identified health literacy measurement tools generally lacked rigorous psychometric evaluation. Future studies should focus on exploring a comprehensive model that encompasses various health models and develop measurement tools with more culturally representative psychometric assessments.
Analysis of activity rhythm and behavior pattern of plateau pika in patchily degraded alpine meadow
Authors: SU Xiaoxue , LI Xilai , Sun Huafang , song zihan 
Published: October 2023

Abstract
In this paper, the ecological habits and activity rhythm of plateau pika (Ochotona curzoniae) in patchily degraded alpine meadow in the Source Zone of the Yellow River (SZYR) on the Qinghai-Tibet Plateau were investigated for the effective prevention and control strategies of plateau pika. Video surveillance cameras for continuous monitoring were employed in the different degraded patches (i.e., active patches (with plateau pika), inactive patches (without plateau pika) and recovered patches) of alpine meadow in the SZYR during March 2021 to February 2022. The time allocation of plateau pika behavior (i.e., digging, foraging, guarding, moving and other behaviors) and activity rhythm (i.e., day, month and season) were analyzed. The results showed that: (1) The peak of ground activity of plateau pika appeared at 10:00 and 16:00, and it was inactive at night, so it belonged to diurnal animals. (2) In the daily behavior activities of plateau pika, the highest frequency of digging and foraging appeared in the periods of 9:00–12:00 and 16:00. (3) The relative frequencies of digging and foraging behavior in season was winter > spring > summer > autumn. (4) The proportion of annual activity distribution of plateau pika, digging and foraging accounted for 66.13%, guarding for 13.35%, moving for 11.64%, and other behaviors for 8.88%. There was a significant difference in the frequency of each behavior between the two groups (P < 0.05). The results which reveal the daily activity rhythm of plateau pika from the perspective of video surveillance camera, are helpful to understand the behavioral ecology of plateau pika and provide scientific basis for the restoration and management of patchy degradation of alpine meadow.
Microorganisms Improve Physiological Performace to Oil Palm Seedings Growth Promote
Authors: Mendonça Danielle Pereira , Brito Maria Luiza Brito , Dias Juliana Tavares , Silva Verônica Daniely Pereira Paes da , Pacheco Mauro Junior Borges , Ferreira Thayná da Cruz , Rodrigues Maria Carolina Sarto Fernandes , Júnior Dalton Dias da Silva , Silva Gisele Barata Da , De Castro Gledson Luiz Salgado 
Published: October 2023

Abstract
Elaeis guineensis Jacq. It is the oilseed that has stood out in the production of oil of high economic value. The main global producers are Malaysia and Indonesia. In Brazil, the cultivated area is concentrated in the state of Pará. Seedling production requires a long nursery period and high consumption of chemical fertilizers. Currently, studies reporting the use of microbial technology to minimize the excessive use of chemical fertilizers and promote earlier seedling development. The objective of this study was to evaluate biometrics, biomass accumulation and gas exchange in oil palm seedlings inoculated with microorganisms. The experiment was conducted in a greenhouse, in a completely randomized design with five treatments, consisting of the inoculation of four Trichoderma microorganisms and a control, with five replications. The data were subjected to analysis of variance and treatment means were compared using the SNK test (P < 0.05). The inoculation of microorganisms promoted the growth of oil palm seedlings. The height, stem diameter, number of leaves, leaf area, root length, total chlorophyll, net photosynthesis, stomatal conductance, transpiration, dry mass of leaves, aerial part, root and total, increased on average in inoculated seedlings compared to control seedlings. Total soluble sugars, on the other hand, decreased for inoculated plants compared to the control. Starch decreased compared to control. Therefore, the results show that better photosynthetic performance may be associated with the promotion of growth in oil palm seeds inoculated with microorganisms. It is likely that some physiological mechanisms are being activated by microorganisms for greater growth.
Acquisition of thermotolerance in slow growing poultry: Elucidating through sequential mechanism of thermal conditioning during embryonic and early post-hatch period
Authors: Nayak Nibedita , Bhanja Subrat Kumar , Chakurkar Eaknath B. , Sahu Amiya Ranjan , Tyagi J.S , Das Bappa , Shinde Krutika R. , Champati Abhijeet 
Published: October 2023

Abstract
This study aimed to elucidate the impact of embryonic thermal conditioning (ETC) in combination with early post-hatch heat conditioning (PHHC) on acquired thermotolerance in slow growing CARI-Debendra birds till 12 weeks. Embryonic conditioning was done only from E11-16 at 39.5°C with RH 60–70% for 5hrs/ day while conventional incubational conditions followed in control. After hatching, the chicks were chosen in a random manner group-wise and further distributed in to two sub groups each (No manipulation, early post-hatch heat conditioning). Early post-hatch heat conditioning was carried out for first five weeks for chicks with brooding temperature of 37 ± 1°C than control. Significant difference was observed in hatch weight and hatching time between ETC and control without any adverse effect on fertility and hatchability. Rectal temperature and surface temperature in ETC group were + 1.04 and + 4.76% higher than the control at hatch which diminishes with age. ETC had improved body weight from 1st wk till 12th wks while heat conditioning group displayed a 1% increase in body weight at six weeks. Stress biomarkers such as concentration of T4, potassium and activity of creatinine kinase enzyme was more in ETC group than control while H/L ratio and concentration of T3 was less in ETC group. Expression dynamics of HSP70 gene was significant only in liver and intestine tissues of ETC group respectively, while GRP78 gene showed tissue-specific upregulation in the intestine of 12-week-old chickens. Embryonic thermal manipulation and early post-hatch heat conditioning positively influenced thermotolerance ability and productivity of slow growing birds.
Intra-articular injection of bone marrow aspirate concentrate in end stage knee osteoarthritis: 4 year results of 37 knees
Authors: Pabinger Christof , Kobinia Georg Stefan , Lothaller Harald 
Published: October 2023

Abstract

Purpose:
Cell based therapies are increasingly used and results of bone marrow aspirate concentrate (BMAC) show encouraging short- to middle term results, superior to hyaluronic acid and platelet rich plasma (PRP). Most studies describe patients with mild to moderate arthritis and short term results of patients with severe osteoarthritis of the knee. Hence, the aim of this prospective study was to investigate the mid-term outcome of BMAC injections in patients with severe osteoarthritis of the knee.
Methods:
The BMAC was retrieved from the iliac crest as previously published with the “reorientation technique” from the iliac crest in prone position in sedoanalgesia and injected into the patients’ osteoarthritic knees. Patients were followed-up for 4 years. WOMAC, IKDC, SF 36 and walking distance were measured in a total of 37 participants.
Results
There was an improvement of IKDC and WOMAC from the first year onwards and a significant improvement beginning from year 2 up to the mid-term follow-up: IKDC increased significantly from 56±12 (range 34-81) to 73±13 (range 45-100), p<.001. WOMAC decreased significantly from 40±23 (range 6-96) to 18 ±18 (range 0-67), p<.001. 35 of 37 knees improved regarding IKDC and WOMAC score from the first to the last follow-up. Not a single protheses had to be implanted. Elaborate statistical analysis was done to exclude covariates and confounders (age, time, BMI,…) .
Conclusion
In summary, this is the first study on BMAC injections into 37 osteoarthritic knees with a 4- year follow up showing significant improvements in IKDC and WOMAC scores, and with a 95% success rate and significant improvement in walking distance.
Level of Evidence: Level I
Benzodiazepine Use in Medical Cannabis Authorization Adult Patients from 2013-2021: Alberta, Canada
Authors: Lee Cerina , PharmD Heidi Fernandes , Lin Mu , Martins Karen J.B. , Dyck Jason R.B. , Klarenbach Scott W. , Richer Lawrence , Jess Ed , Hanlon John G. , Hyshka Elaine , Eurich Dean T. 
Published: October 2023

Abstract
Background
Benzodiazepines are a class of medications that are being increasingly prescribed in Canada but carry significant risk of harm. There has been increasing clinical interest on the potential “sparing effects” of medical cannabis as one strategy to reduce benzodiazepine use. The objective of this study as to examine the association of medical cannabis authorization with benzodiazepine usage between 2013–2021 in Alberta, Canada.
Methods
A propensity score matched cohort study with patients on regular benzodiazepine treatment authorized to use medical cannabis compared to controls who do not have authorization for medical cannabis. A total of 9690 medically authorized cannabis patients were matched to controls. To assess the effect of medical cannabis use on daily average diazepam equivalence (DDE), interrupted time series (ITS) analysis was used to assess the change in the trend of diazepam equivalence in the 26 weeks (6 months) before and 52 weeks (1 year) after the authorization of medical cannabis.
Results
Over the 1-year follow-up period after medical cannabis authorization, there was no overall change in the DDE use in authorized medical cannabis patients compared to matched controls (-0.27 DDE, 95% CI: -0.62 to 0.08). With respect to prescription benzodiazepine discontinuation any time after the index date, similar rates of 51.5% (4986/9690) and 49.2% (4766/9690) of those authorized medical cannabis and controls, respectively, ceased using benzodiazepine during the follow-up (p < 0.001).
Conclusions
This short-term study found that medical cannabis authorization had minimal effects on benzodiazepine use. Our findings may contribute ongoing evidence for clinicians regarding the potential impact of medical cannabis to reduce benzodiazepine use.
Despite treatment, HbA1c &gt; 37mmol/mol in the first trimester is associated with premature delivery among South Asian women with gestational diabetes mellitus: a retrospective cohort study
Authors: Punnose John , Malhotra Rajeev Kumar , Sukhija Komal ,   Rashika M Rijhwani1, Choudhary Naimaa , Sharma Asha 
Published: October 2023

Abstract

Purpose: To examine the effects of first-trimester HbA1c (HbA1c-FT) >37mmol/mol on preterm birth (PTB) and large-for-gestational-age (LGA) babies in a retrospective cohort of South Asian pregnant women with gestational diabetes (GDM).
Methods: The cohort (n = 686) was separated into two groups based on HbA1c-FT values: Group A (n=97) and Group B (n=589), with values of 37-46 mmol/mol (5.5-6.4%) and <37 mmol/mol (5.5%), respectively. HbA1c-FT's independent influence on PTB and LGA babies was examined using multivariable logistic regression in groups A and B women. The reference group (Group C) included 2031 non-GDM women with HbA1c-FT <37 mmol/mol (<5.5%). The effects of HbA1c-FT on PTB and LGA babies in obese women in Groups A, B, and C (designated as A-ob, B-ob, and C-ob, respectively) were re-analyzed using multivariable logistic regression.
Results: Group A GDM women with greater HbA1c-FT had a higher risk for PTB (aOR: 1.90, 95% CI: 1.12 to 3.20) but not LGA babies (aOR: 1.20, 95%: 0.74 to 1.95). The risk of PTB was higher for obese women in Group A-ob: aOR 3.15 [95% CI 1.62 to 6.15]. However, GDM women with normal HbA1c-FT exhibited no elevated risk for PTB: Groups B and B-ob had aORs of 1.17.(95% CI 0.89 to 1.55) and 1.29 (95% CI 0.84 to 1.97) respectively.
Conclusions: South Asian GDM women with prediabetic HbA1c FT; 37-46 mmol/mol (5.5-6.4%) are more likely to deliver preterm babies despite treatment, while the risk for LGA babies was the same as non-GDM women.
Of goats and heat, the differential impact of summer temperature on habitat selection and activity patterns in mountain goats (Oreamnos americanus) of different ecotypes
Authors: Michaud A. , White K. S. , Hamel S. , Richard J. H. , Côté S.D. 
Published: October 2023

Abstract
Climate change disproportionately affects northern and alpine environments, with faster rates of warming than the global average. In this context, understanding the effect of projected temperature increase on the species inhabiting these ecosystems is essential. Most alpine and northern ungulates are particularly well adapted to low temperatures and must modify their behaviour when temperatures exceed a critical threshold. We analyzed the influence of summer weather conditions, particularly temperature, on the activity patterns and habitat selection of four populations of a mountain specialist, the mountain goat (Oreamnos americanus), representing the two ecotypes found in this species - coastal and continental. We collected GPS location and activity sensor data during 2010-2019 from 223 mountain goats in four different study areas in both the coastal range of Alaska and the Rocky Mountains of Alberta. Mountain goats of each ecotype used different habitat selection tactics to avoid thermal stress. When temperatures increased, mountain goats of both ecotypes decreased selection for alpine meadows, but goats in coastal environments increased selection for open habitats close to snow, while continental goats increased selection for forest environments. With respect to altitude, mountain goats in continental environments selected higher elevation open habitats only when temperature increased. In coastal environments, goats selected higher elevation habitats at all temperatures, but the selection for high elevations was strongest in warm conditions. Mountain goats of both ecotypes reduced the proportion of time spent active when temperatures increased during the middle of the day. Our study shows that mountain goats use diverse tactics that are likely to mitigate thermal stress. Mountain goats living in different ecosystems use alternative tactics. The observed ecotypic variation highlights the importance of assessing the impact of climate change at the population rather than the species level, a pattern that arises because populations are experiencing different environmental constraints.
Xinfeng capsule inhibits cartilage extracellular matrix degradation and inflammation in osteoarthritis by modulating circ_0032131 and miR-502-5p/TRAF2 axis
Authors: zhouqiao Qiao , Liu Jian , Hu Yuedi , Qi Yajun 
Published: October 2023

Abstract

Clinical practice has proved that Xinfeng capsule (XFC) can effectively cure osteoarthritis (OA). In our study, we investigated the molecular mechanism and role of XFC in the treatment of OA using network pharmacology and cellular experiments. hsa_circ_0032131 was overexpressed in OA peripheral blood mononuclear cells (PBMCs). Both PBMCs and chondrocytes are cellular members of the inflammatory microenvironment in OA. To investigate the function of hsa_circ_0032131 in PBMCs stimulated chondrocytes. A series of functional experiments revealed the relationship between hsa_circ_0032131 and the miR-502-5p/TRAF2 axis. To further determine whether XFC might treat OA through the interaction of circ_0032131 with the miR-502-5p/TRAF2 axis. CKK-8 assay and flow cytometry were conducted to detect the proliferation and apoptosis process of XFC-treated cells. Multiple experimental methods were utilized to detect the expression levels of inflammatory factors, extracellular matrix, and so on. The results demonstrated that the expression of hsa_circ_0032131 was obviously elevated in PBMCs of OA patients and correlated with clinical immuno-inflammatory factors and ECM indexes. Network pharmacology verified that the chief active ingredients of XFC exerted their roles mainly in the regulation of inflammation (IL1A, IL1B, IL4), extracellular matrix metabolism (MMP13, COL2A1), and tumour necrosis factor (TNF, TRAF2). In vitro experiments revealed that knockdown of circ_0032131 in PBMCs-stimulated chondrocytes inhibited apoptosis, inflammation and ECM degradation. Circ_0032131 was verified as a sponge of miR-502-5p by targeting, and TRAF2 was a direct target of miR-502-5p. In addition, rescue experiments verified that XFC blocked the effects of hsa_circ_0032131 overexpression on extracellular matrix, inflammation and cell viability. XFC has a favorable anti-inflammatory effect on OA, and its molecular mechanism was preliminarily elucidated.