bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquired hyperexcitable peripheral nerve disorders: Clinical and laboratory features, therapeutic responses, and long‐term follow‐up
Authors: Khadilkar Satish V. , Pandya Darshan C. , Dhonde Pramod , Patel Bhagyadhan , Bharucha Nadir E. , Patil Varsha A. , Patel Riddhi B. , Halani Hiral A. , Ghurye Nirbha , Mansukhani Khushnuma , Dhonde Mayura 
Published: November 2023

AbstractIntroduction/AimsHyperexcitable peripheral nerve disorders (HPNDs) are rare. Although their clinical and laboratory features have been well studied, information on treatment and follow‐up is limited. The aim of this study is to explore the long‐term clinical, investigative, and therapeutic profile of patients with acquired HPNDs.MethodsThis study retrospectively analyzed patients from a single tertiary care center with HPND (January 2012 to January 2022). Patients were recruited according to published inclusion and exclusion criteria. Details of clinical features, diagnostic tests, therapeutic interventions, and follow‐up were recorded. This study included patients with follow‐up of 2 or more years.ResultsA total of 32 patients (M = 26, F = 6) were studied. The common clinical features included myokymia, neuropathic or shock‐like pain, cramps, sleep disturbances, encephalopathy, cerebellar ataxia, and seizures. A total of 81.25% of patients responded favorably to corticosteroids and membrane stabilizers. Among the nonresponders, five received intravenous immunoglobulin (IVIG), and one received plasma exchange (PLEX). Two patients required rituximab due to poor responses to the above treatments. The mean duration of response was 6 weeks (4–24 weeks) from the initiation of treatment. All patients had favorable outcomes, reaching clinical remission within 1–5 years from the initiation of treatment. Only two patients had relapses. Immunotherapy could be stopped in 78% of patients within 3 years and 100% by 5 years.DiscussionChronic immunosuppression starting with corticosteroids is required for satisfactory outcomes of HPNDs. These disorders usually run a monophasic course, and relapses are uncommon.
Biocompatible hydrogels comprised of collagen, chitosan and polyurethane with potential applications for wound healing and controlled drug release
Authors: Caldera‐Villalobos Martín , Ramos‐Montañez Daniela G , Cabrera‐Munguía Denis A , Becerra‐Rodriguez Juan J , Rodríguez‐Fuentes Nayeli , Claudio‐Rizo Jesús A 
Published: November 2023

AbstractChitosan and collagen are two valuable biopolymers for the synthesis and design of biomaterials. In this work, we evaluate the effect of the concentration of chitosan on the physicochemical and biological properties of polyurethane‐crosslinked collagen hydrogels. Chitosan was added with a proportion ranging from 0 to 40 wt%. Depending on the aminoglycoside content, semi‐interpenetrating polymeric networks (semi‐IPNs) or completely IPNs were generated; this is attributed to the occlusion of the chitosan granules in the reticulated fibrillar matrix. The presence of chitosan in these hydrogels provides antibacterial capacity against pathogenic microorganisms such as Escherichia coli, which is corroborated by inhibition halo experiments. Hydrogels with 40 wt% of chitosan only showed improvement in the gelation time and mechanical performance, indicating a dependent relation of these properties with respect to the aminopolysaccharide content. Hydrogels with 10 wt% of chitosan showed the best biomedical performance. They also have the highest reticulation, swelling capability and chemical stability against degradation events such as hydrolysis and proteolysis. Further, they have the best biocompatibility for human monocytes, and they stimulate the secretion of monocyte chemotactic protein‐1 and tumor necrosis factor‐alpha. Also, these hydrogels showed a controlled release of ketorolac at pH 7 and 37 °C. The results of these in vitro biological tests demonstrate the potential application of novel biopolymer‐based hydrogels in chronic wound healing due to their antibacterial capacity and modulation of the biological response of specialized cells in dermal repair treatments, as well as for the design of smart materials for the controlled release of drugs. © 2023 Society of Industrial Chemistry.
Number of children in the household influences respiratory morbidities in children with bronchopulmonary dysplasia in the outpatient setting
Authors: Collaco Joseph M. , Tsukahara Katharine R. , Tracy Michael C. , Sheils Catherine A. , Rice Jessica L. , Rhein Lawrence M. , Popova Antonia P. , Nelin Leif , Miller Audrey N. , Manimtim Winston M. , Levin Jonathan C. , Lai Khanh , Kaslow Jacob A. , Hayden Lystra P. , Bansal Manvi , Austin Eric D. , Aoyama Brianna , Akangire Gangaram , Agarwal Amit , Villafranco Natalie , McGrath‐Morrow Sharon A. 
Published: November 2023

AbstractBackgroundBronchopulmonary dysplasia (BPD), a common complication of prematurity, is associated with outpatient morbidities, including respiratory exacerbations. Daycare attendance is associated with increased rates of acute and chronic morbidities in children with BPD. We sought to determine if additional children in the household conferred similar risks for children with BPD.MethodsThe number of children in the household and clinical outcomes were obtained via validated instruments for 933 subjects recruited from 13 BPD specialty clinics in the United States. Clustered logistic regression models were used to test for associations.ResultsThe mean gestational age of the study population was 26.5 ± 2.2 weeks and most subjects (69.1%) had severe BPD. The mean number of children in households (including the subject) was 2.1 ± 1.3 children. Each additional child in the household was associated with a 13% increased risk for hospital admission, 13% increased risk for antibiotic use for respiratory illnesses, 10% increased risk for coughing/wheezing/shortness of breath, 14% increased risk for nighttime symptoms, and 18% increased risk for rescue medication use. Additional analyses found that the increased risks were most prominent when there were three or more other children in the household.ConclusionsWe observed that additional children in the household were a risk factor for adverse respiratory outcomes. We speculate that secondary person‐to‐person transmission of respiratory viral infections drives this finding. While this risk factor is not easily modified, measures do exist to mitigate this disease burden. Further studies are needed to define best practices for mitigating this risk associated with household viral transmission.
Airway findings in trisomy 13 and trisomy 18: A 10‐year retrospective review
Authors: Dress Carolyn , Silva Cherie T. , von Allmen Douglas C. , Zak Sara 
Published: November 2023

AbstractBackground and ObjectivesTrisomy 18 and trisomy 13 are the most common autosomal trisomies following trisomy 21, with overall incidence rising. Both diagnoses are characterized by multisystem involvement and were previously thought to be incompatible with life. New data suggest that prolonged survival is possible, and thus many families are opting for more aggressive medical interventions. This study aims to describe airway findings in trisomy 18 and trisomy 13, as these have not been comprehensively studied and can impact medical decision‐making. We hypothesize that most children with trisomy 18 and trisomy 13 will have abnormal findings on airway endoscopy.MethodsThis a 10‐year retrospective analysis of children with trisomy 13 or trisomy 18 who underwent endoscopic airway evaluation at a single center between 2011 and 2021. A total of 31 patients were evaluated.ResultsThirty‐one patients were included and underwent flexible bronchoscopy by a pediatric pulmonologist, often in conjunction with rigid bronchoscopy performed by pediatric otolaryngology. Findings were typically complimentary. All patients had at least one clinically significant finding on evaluation, and most patients had both upper and lower airway, as well as static and dynamic airway findings. The most common airway findings in children with trisomy 13 and 18 include tracheomalacia, bronchomalacia, laryngomalacia, hypopharyngeal collapse, glossoptosis, and bronchial compression.ConclusionThese findings can have significant implications for clinical care, and thus knowledge of trends has the potential to improve counseling on expected clinical course, presurgical planning, and informed consent before interventions.
Changes in clinical, demographic, and outcome patterns of children hospitalized with non‐SARS‐CoV‐2 viral low respiratory tract infections before and during the COVID pandemic in Rome, Italy
Authors: Buonsenso Danilo , Ferro Valentina , Viozzi Francesca , Morello Rosa , Proli Francesco , Bersani Giulia , Lazzareschi Ilaria , santangelo Rosaria , Sanguinetti Maurizio , Fiori Barbara , Zampino Giuseppe , Valentini Piero 
Published: November 2023

AbstractIntroductionWe performed this study aiming to evaluate changes in epidemiology, clinical presentation and outcomes of children hospitalized for viral lower respiratory tract infections (LRTI).MethodsWe performed a retrospective study of children younger than 18 years of age hospitalized for LRTIs with a positive respiratory viral testing from 2018 to 2022. We compared need of pediatric intensive care unit (PICU), invasive ventilation, and other respiratory support, viral etiologies, clinical presentations, imaging, and laboratory results in the precovid (2018–2019) and covid (2020–2022) period.ResultsA total of 523 were included in the analysis. In the pandemic period, the detection of influenza was 95% less likely to occur (odds ratio [OR]: 0.05; 95% confidence interval [95% CI]: 0.02–0.12; p < .001), likewise the detection of adenovirus was 77% less likely to occur (OR: 0.23; 95% CI: 0.10–0.51; p < .001). In the pandemic period, the number of codetections increased from 15.52% in 2018 to 57.25% in 2022, resulting in a significantly increasing trend (p < .001). The odds of transfer to PICU was more than five times greater during the pandemic period (OR: 5.31; 95% CI: 1.78–15.86; p = .003).ConclusionsWe found that the pattern of LRTI in children during COVID‐19 pandemic significantly changed in terms of etiologies and increased severity.
Only kosmotrope anions trigger fibrillization of the recombinant core spidroin eADF4(C16) from Araneus diadematus
Authors: Hovanová Veronika , Hovan Andrej , Humenik Martin , Sedlák Erik 
Published: November 2023

AbstractRecombinant core spidroin eADF4(C16) has received increasing attention due to its ability to form micro‐ and nano‐structured scaffolds, which are based on nanofibrils with great potential for biomedical and biotechnological applications. Phosphate anions have been demonstrated to trigger the eADF4(C16) self‐assembly into cross‐beta fibrils. In the present work, we systematically addressed the effect of nine sodium anions, namely SO42−, HPO42− (Pi), F−, Cl−, Br−, NO3−, I−, SCN−, and ClO4− from the Hofmeister series on the in vitro self‐assembly kinetics of eADF4(C16). We show that besides the phosphate anions, only kosmotropic anions such as sulfate and fluoride can initiate the eADF4(C16) fibril formation. Global analysis of the self‐assembly kinetics, utilizing the platform AmyloFit, showed the nucleation‐based mechanism with a major role of secondary nucleation, surprisingly independent of the type of the kosmotropic anion. The rate constant of the fibril elongation in mixtures of phosphate anions with other studied anions correlated with their kosmotropic or chaotropic position in the Hofmeister series. Our findings suggest an important role of anion hydration in the eADF4(C16) fibrillization process.
Reliability evaluation of a complex system that considers the influence of the fluctuation degree of the performance degradation trajectory
Authors: Feng Cong , Yang Zhaojun , Chen Chuanhai , Liu Zhifeng , Guo Jinyan , Zhou Jie 
Published: November 2023

AbstractIn this paper, a reliability evaluation method based on the hidden Markov model (HMM) considers the influence of degradation trajectory fluctuation. To address the problem in which the performance degradation trajectory modelling of complex systems is limited by sampling time points, this method constructs an approximate degradation trajectory model based on effective discrete data points through a radial basis function to realize the degradation data expansion of small samples. Then, the average degradation rate is defined, and the fluctuation degree of the degradation trajectory is quantitatively evaluated to obtain the evaluation function of the fluctuation degree of the degradation trajectory. In addition, to determine the relationship between the fluctuation degree of the degradation trajectory and the operating state of the system, the method combines HMM with the evaluation function of the fluctuation degree of the degradation trajectory and obtains the transition probability matrix of different operating states of the system affected by the fluctuation degree of the degradation trajectory. On the basis of the probability matrix of the failure state, the reliability change curve of the system is derived. Finally, the effectiveness of the proposed method is verified via an example of a computer numerical control machine tool.
Robotic versus laparoscopic distal pancreatectomy for pancreatic adenocarcinoma in obese patients
Authors: Ausania Fabio , Landi Filippo , González‐Abós Carolina , Martinie John B. , Vrochides Dionisios , Walsh Matthew , Hossain Shanaz M. , White Steven , Prabakaran Viswakumar , Melstrom Laleh G. , Fong Yuman , Valle Valentina , Bing Yuntao , Xiu Dianrong , Di Franco Gregorio , de' Angelis Nicola , Laurent Alexis , Giuliani Giuseppe , Pernazza Graziano , Memeo Riccardo , Rios José , Coratti Andrea , Morelli Luca , Giulianotti Pier C. 
Published: November 2023

AbstractBackgroundRobotic distal pancreatectomy (RDP) is associated with a lower conversion rate and less blood loss than laparoscopic distal pancreatectomy (LDP). LDP has similar oncological outcomes as open surgery in PDAC. The aim of this study was to compare perioperative and oncological outcomes in obese patients with RDP versus LDP for PDAC.Materials and methodsRetrospectively, all obese patients who underwent RDP or LDP for PDAC between 2012 and 2022 at 12 international expert centres were included.Resultsout of 372, 81 patients were included. All baseline features were comparable between the two groups. RDP was associated with decreased blood loss (495mlLDP vs. 188mlRDP; p = 0.003), lower conversion rate (13.5%RDP vs. 36.4%LDP; p = 0.019) and lower rate of Clavien‐Dindo ≥3 complications (13.5%RDP vs. 36.4%LDP; p = 0.019). Overall and disease‐free survival were comparable.ConclusionsIn obese patients with left‐sided PDAC, the robotic approach was associated with improved intraoperative outcomes and fewer severe complications.
Appearance of Structural Color by Constructing Highly Regular Single‐Particle Layers on a Water Surface of Organo‐Modified Magnetite with Different Particle Diameter
Authors: Kikuchi Nanata , Yamagishi Yui , Fujimori Atsuhiro 
Published: November 2023

AbstractUsing triiron tetroxide/magnetite particles with particle diameters of 5 nm and 30 nm, the structural color occurrence behavior due to multi‐particle layer formation was compared. The −OH‐terminated groups on the surface of the outermost layer of magnetite were bound with long‐chain fatty acids to obtain amphiphilic organo‐modified magnetite. Organo‐modified magnetite was spread as a single‐particle layer on the water surface and layered in multiple layers on a solid substrate. Organo‐modified magnetite multilayers layered to a thickness close to the wavelength of visible light exhibited a clear structural color, regardless of the particle size. However, in the case of fine particles with a diameter of 5 nm, the structural color did not appear when the in‐plane packing density was low, and the density of the two‐dimensional plane played an important role. In comparison, in the same production process and particle type, a clearer structural color was expressed with a diameter of 30 nm, and individual differences in physical properties were also confirmed when other nanoparticle types were used.
Electrochemical Biosensor for Ultrasensitive Detection of Microrna‐21 through In Situ Synthesis of Palladium Nanoparticles
Authors: Huang Weibo , Ma Nan , Kong Jinming , Zhang Xueji 
Published: November 2023

AbstractThe detection of trace microRNAs (miRNA) is crucial for early cancer diagnosis. Here, a sensitive biosensor for miRNA directive detection was put forward, which was based on RNA‐templated palladium nanoparticles (PdNPs) signal amplification strategy. Uncharged peptide nucleic acids (PNA) probe was used to capture the target miRNA(T‐RNA) specifically. Subsequently, a large amount of palladium ions absorbed on T‐RNA strands via electrostatic forces, and the palladium nanocluster is rapidly generated based on chemical reduction. Obviously, RNA metallization method enables biosensor to be carried out efficiently at room temperature also simplifies the preparation and detection of the sensor. Under optimal conditions, this method can analyze the concentration of miRNA in the range of 10 fM to 1 nM, and the detection limit is 3.33 fM. At the same time, this method has strong anti‐interference ability in serum samples, which provides a broad prospect for the early screening and diagnosis of cancer.
Rational Construction ZnO@C3N4 Composite with Enhanced Photocorrosion‐Resistance for Simultaneous Removal of RhB‐MO Mixed Pollutants
Authors: Kang Haiyan , Mao Yanli , Huang Zhenzhen , Zhu Xinfeng , Wang Kai , Zhang Xia , Geng Hongchao , Han Changrui , Song Zhongxian 
Published: November 2023

AbstractA series of ZnO@C3N4 composites with excellent photocorrosion‐resistant and photocatalytic activity were prepared by using one‐pot calcination synthesis for the removal of organic pollutants from wastewater. Compared with ZnO and C3N4, ZnO@C3N4 presented the excellent photocatalytic performance for RhB, MO, DBP and RhB‐MO mixed systems under UV conditions. The degradation rate constants of 70ZnO@30 C3N4 for RhB and DBP were 7.66 and 4.71 times higher than those of ZnO, respectively. For RhB‐MO mixed systems, the rate constant was 4.65 times higher than that of RhB alone. XRD and FTIR analyses indicated a strong phase interaction between two components of ZnO@C3N4 composites. XPS results confirmed the formation of ZnO/C3N4 heterojunction. In addition, the mechanisms underlying the highly efficient catalytic performance of ZnO@C3N4 composites in the degradation of organic pollutants were also analyzed. It can be attributed to the fact that a tight contact at the interface and well‐matched band edge position between ZnO and C3N4 can effectively separate and transfer photoinduced carriers for organic pollutant degradation, rather than react with ZnO itself. This study clearly demonstrates a simple way to fabricate ZnO@C3N4 with photocorrosion‐resistant and to apply them for the removal of multi‐component organic pollutants from wastewater by photocatalysis.
Single Pulse Nanosecond Laser‐Stimulated Targeted Delivery of Anti‐Cancer Drugs from Hybrid Lipid Nanoparticles Containing 5 nm Gold Nanoparticles
Authors: Uzel Antoine , Agiotis Leonidas , Baron Amélie , Zhigaltsev Igor V. , Cullis Pieter R. , Hasanzadeh Kafshgari Morteza , Meunier Michel 
Published: November 2023

AbstractEncapsulating chemotherapeutic drugs like doxorubicin (DOX) inside lipid nanoparticles (LNPs) can overcome their acute, systematic toxicity. However, a precise drug release at the tumor microenvironment for improving the maximum tolerated dose and reducing side effects has yet to be well‐established by implementing a safe stimuli‐responsive strategy. This study proposes an integrated nanoscale perforation to trigger DOX release from hybrid plasmonic multilamellar LNPs composed of 5 nm gold (Au) NPs clustered at the internal lamellae interfaces. To promote site‐specific DOX release, a single pulse irradiation strategy is developed by taking advantage of the resonant interaction between nanosecond pulsed laser radiation (527 nm) and the plasmon mode of the hybrid nanocarriers. This approach enlarges the amount of DOX in the target cells up to 11‐fold compared to conventional DOX‐loaded LNPs, leading to significant cancer cell death. The simulation of the pulsed laser interactions of the hybrid nanocarriers suggests a release mechanism mediated by either explosive vaporization of thin water layers adjacent to AuNP clusters or thermo‐mechanical decomposition of overheated lipid layers. This simulation indicates an intact DOX integrity following irradiation since the temperature distribution is highly localized around AuNP clusters and highlights a controlled light‐triggered drug delivery system.
Starch Foams and Their Additives: A Brief Review
Authors: Figueiró Camila da Silva , Calcagno Carmen Iara Walter , Santana Ruth Marlene Campomanes 
Published: November 2023

AbstractShort‐life packaging has been contributing to the increased consumption of polymers. Expanded polystyrene (EPS) is a material that is widely used in disposable packaging, however, its residue occupies a large volume, is difficult to degrade, and its recycling is expensive. That's why the interest in looking for a material of natural and biodegradable origin that can be an alternative to petrochemical‐based polymers. One possibility would be starch, which is a natural and biodegradable polysaccharide and can be extracted from different sources. However, natural starch does not have good properties for commercial application, requiring chemical modifications and/or the incorporation of additives. This article carried out a compilation of current studies that work on the development of packaging, whether film or foams, based on plasticized starch (TPS), and analyzes the influence of the incorporation of additives or treatments carried out in the starch. The blowing agent decreases foam density, cell size, and increases cell density. Incorporation of glycerol in starch foams increases the gelatinization temperature, decreases viscosity and resistance to expansion. The surfactant decreases the density and moisture absorption of the foam, the nucleating agent acted by increasing the mechanical strength and density of the foam, and decreases the absorption of water.