bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choroid plexus vascular reactivity in moyamoya: Implications for choroid plexus regulation in ischemic stress
Authors: Han Caleb , Waddle Spencer , Garza Maria , Davis Larry T. , Eisma Jarrod J. , Richerson Wesley T. , Fusco Matthew , Chitale Rohan , Custer Chelsea , McKnight Colin D. , Jordan Lori C. , Donahue Manus J. 
Published: October 2023

AbstractBackground and PurposeChoroid plexus (ChP) hyperemia has been observed in patients with intracranial vasculopathy and to reduce following successful surgical revascularization. This observation may be attributable to impaired vascular reserve of the ChP or other factors, such as the ChP responding to circulating markers of stress. We extend this work to test the hypothesis that vascular reserve of the ChP is unrelated to intracranial vasculopathy.MethodsWe performed hypercapnic reactivity (blood oxygenation level‐dependent; echo time = 35 ms; spatial resolution = 3.5 × 3.5 × 3.5 mm, repetition time = 2000 ms) and catheter angiography assessments of ChP reserve capacity and vascular patency in moyamoya patients (n = 53) with and without prior surgical revascularization. Time regression analyses quantified maximum cerebrovascular reactivity and reactivity delay time in ChP and cortical flow territories of major intracranial vessels with steno‐occlusion graded as <70%, 70%‐99%, and occlusion using Warfarin‐Aspirin‐Symptomatic‐Intracranial‐Disease stenosis grading criteria. Analysis of variance (significance: two‐sided Bonferroni‐corrected p < .05) was applied to evaluate cortical and ChP reactivity, after accounting for end‐tidal carbon dioxide change, for differing vasculopathy categories.ResultsIn patients without prior revascularization, arterial vasculopathy was associated with reduced cortical reactivity and lengthened reactivity delay (p ≤ .01), as expected. Regardless of surgical history, the ChP reactivity metrics were not significantly related to the degree of proximal stenosis, consistent with ChP reactivity being largely preserved in this population.ConclusionsFindings are consistent with ChP reactivity in moyamoya not being dependent on observed vasculopathy. Future work may investigate the extent to which ChP hyperemia in chronic ischemia reflects circulating markers of glial or ischemic stress.
Association between statin compliance and risk of dementia among patients with chronic periodontitis
Authors: Kim Yu‐Rin , Son Minkook , Kim Seon‐Rye 
Published: October 2023

AbstractObjectivesWe investigated the association between statin compliance and the risk of dementia among patients with chronic periodontitis.MethodsChronic periodontitis patients were extracted from the National Health Insurance Service‐Health Screening Cohort Database, covering the period from 2002 to 2019. A total of 22,089 subjects were included in the study and divided into three groups based on their compliance with statin administration. The Cox proportional hazard model was utilized to calculate hazard ratios and 95% confidence intervals for analyzing the risk of dementia.ResultsIn the restricted cubic spline of the multivariable‐adjusted model, the hazard ratio for dementia decreased prominently with a higher medication possession ratio. The hazard ratios and 95% confidence intervals in the multivariable‐adjusted model for dementia risk in the middle and high medication possession ratio groups, compared to the low medication possession ratio group, were confirmed as 0.70 (0.57–0.87) and 0.57 (0.45–0.72), respectively. In the subgroup analysis, a significant association between dementia and good statin medication possession ratio was found in both severe periodontitis and mild periodontitis cases.ConclusionsOur findings suggest that a group of patients with chronic periodontitis who maintain good statin compliance are associated with a reduced risk of dementia.
An open problem for the metaphysics of constitutive standards
Authors: Molina Yohan 
Published: October 2023

AbstractJeremy Fix, in ‘Two Sorts of Constitutivism’ (2021), makes a case for the possibility of contingent essential properties to account for the metaphysical status of constitutive standards of things. In this brief note, I will present an open problem affecting Fix's conception, namely, the explanation of the membership of particulars to a genus, which is necessary to identify particulars subject to standards.
From indeterminacy in a fundamental theory to fundamental indeterminacy?
Authors: Lee Chanwoo 
Published: October 2023

AbstractIn this paper, I examine a case for fundamental indeterminacy (FI) by Elizabeth Barnes and offer my counterarguments. Barnes' account of FI includes both the characterization of FI and why we need to accept it. I argue that her reasons for accepting FI can be challenged even when we accept her characterization of FI. Her main claim is that finding a fundamental proposition that our fundamental theory is indeterminate about (FPF) gives us a reason to accept FI in metaphysics. I challenge her claim by pointing out more plausible options to address FPFs. An FPF may either indicate that the theory is nonfundamental or lead us to accept the antirealist view; there is no room for FI in either option. One may insist on accepting FI, but I argue that it is not theoretically rewarding enough. Hence, Barnes' case for FI can be contested.
TMPyP‐mediated photoinactivation of Pseudomonas aeruginosa improved in the presence of a cationic polymer
Authors: Campagno Luciana P. , Quiroga Ezequiel D. , Durantini Edgardo N. , Alovero Fabiana L. 
Published: October 2023

AbstractPseudomonas aeruginosa is one of the most refractory organisms to antibiotic treatment and appears to be one of the least susceptible to photodynamic treatment. TMPyP is effective in the photoinactivation of P. aeruginosa, and the co‐administration with the cationic polymer Eudragit®‐E100 (Eu) potentiates this effect against isolates both sensitive and resistant to antibiotics. The fluorescent population (>98%) observed by flow cytometry after exposure to Eu + TMPyP remained unchanged after successive washings, indicating a stronger interaction/internalization of TMPyP in the bacteria, which could be attributed to the rapid neutralization of surface charges. TMPyP and Eu produced depolarization of the cytoplasmic membrane, which increased when both cationic compounds were combined. Using confocal laser scanning microscopy, heterogeneously distributed fluorescent areas were observed after TMPyP exposure, while homogeneous fluorescence and enhanced intensity were observed with Eu + TMPyP. The polymer caused alterations in the bacterial envelopes that contributed to a deeper and more homogeneous interaction/internalization of TMPyP, leading to a higher probability of damage by cytotoxic ROS and explaining the enhanced result of photodynamic inactivation. Therefore, Eu acts as an adjuvant without being by itself capable of eradicating this pathogen. Moreover, compared with other therapies, this combinatorial strategy with a polymer approved for pharmaceutical applications presents advantages in terms of toxicity risks.
Policy agenda trade‐offs for sustainability: The compositional change of attention about energy in legislative hearings
Authors: Sohn Hyodong 
Published: October 2023

AbstractThe evaluation of relative changes in policy agenda composition using dynamic compositional models can offer a useful way to lead future studies of policy agenda trade‐offs for sustainability. As a specific empirical case, this study examines changes in the annual composition of legislative attention in the United States congressional hearings on energy as a substantive issue domain. Using the description texts of hearings, this article assesses the compositional energy topic changes of conventional agendas, other general agendas, and unconventional agendas, including environmental and social agendas. By focusing on how economic contextual shocks, along with political factors, shape the energy agenda attention mix, this study discovers that conventional agendas related to energy topics in U.S. congressional hearings are relatively less likely to be discussed when economic conditions are adverse under Democratic legislature controls. It illustrates example conditions under which policy agenda subtopics for sustainability are more likely to be pursued at the expense of which subtopics.Related ArticlesHeidbreder, Brianne. 2012. “Agenda Setting in the States: How Politics and Policy Needs Shape Gubernatorial Agendas.” Politics & Policy 40(2): 296–319. https://doi.org/10.1111/j.1747‐1346.2012.00345.x.Morini, Marco, and Marco Cilento. 2020. “New Parties, Fractionalization, and the Increasing Duration of Government Formation Processes in the EU Member States.” Politics & Policy 48(6): 1202–32. https://doi.org/10.1111/polp.12381.Steger, Wayne P. 2008. “The President's Legislative Program: An Issue of Sincere versus Strategic Behavior.” Politics & Policy 33(2): 312–29. https://doi.org/10.1111/j.1747‐1346.2005.tb00645.x.
EBUS‐TBNA for mediastinal staging of centrally located T1N0M0 non‐small cell lung cancer clinically staged with PET/CT
Authors: Serra Mitjà Pere , García‐Cabo Bruno , Garcia‐Olivé Ignasi , Radua Joaquim , Rami‐Porta Ramón , Esteban Lluís , Barreiro Bienvenido , Call Sergi , Centeno Carmen , Andreo Felipe , Obiols Carme , Ochoa Juan Manuel , Martínez‐Palau Mireia , Reig Nina , Serra Mireia , Sanz‐Santos José 
Published: October 2023

AbstractBackground and ObjectiveTo evaluate the diagnostic accuracy and clinical usefulness of endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) for mediastinal staging of centrally located T1N0M0 non‐small cell lung cancer (NSCLC) clinically staged with positron emission tomography/computed tomography (PET/CT).MethodsWe conducted a study that included patients with centrally located T1N0M0 NSCLC, clinically staged with PET/CT who underwent EBUS‐TBNA for mediastinal staging. Patients with negative EBUS‐TBNA underwent mediastinoscopy, video‐assisted mediastinoscopic lymphadenectomy (VAMLA) and/or lung resection with systematic nodal dissection, that were considered the gold standard. The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), overall accuracy of EBUS‐TBNA for diagnosing mediastinal metastases (N2 disease) and the number needed to treat (NNT: number of patients needed to undergo EBUS‐TBNA to avoid a case of pathologic N2 disease after resection) were calculated.ResultsOne‐hundred eighteen patients were included. EBUS‐TBNA proved N2 disease in four patients. In the remaining 114 patients who underwent mediastinoscopy, VAMLA and/or resection there were two cases of N2 (N2 prevalence 5.1%). The sensitivity, specificity, NPV, PPV and overall accuracy for diagnosing mediastinal metastases (N2 disease) were of 66%, 100%, 98%, 100% and 98%, respectively. The NNT was 31 (95% CI: 15–119).ConclusionEBUS‐TBNA in patients with central clinically staged T1N0M0 NSCLC presents a good diagnostic accuracy for mediastinal staging, even in a population with low prevalence of N2 disease. Therefore, its indication should be considered in the management of even these early lung cancers.
Artificial intelligence analysis of over a million Chinese men and women reveals level of dark circle in the facial skin aging process
Authors: Li Tian‐Hao , Ma Xu‐Da , Li Zi‐Ming , Yu Nan‐Ze , Song Jin‐Yan , Ma Zi‐Tao , Ying Han‐ting , Zhou Beibei , Huang Jiu‐Zuo , Wu Liang , Long Xiao 
Published: October 2023

AbstractBackgroundTo better compare the progression of dark circles and the aging process in Chinese skin. A total of 100 589 Chinese males and 1 838 997 Chinese females aged 18 to 85, without facial skin conditions, and who had access to a smartphone with a high‐resolution camera all took selfies.MethodUsing a smartphone application with a built‐in artificial intelligence algorithm, facial skin diagnostic evaluated the selfies and score the severity of the dark circles with four other facial indicators (including skin type, Pores, Acne vulgaris, and Blackheads). Basic information was collected with online questionnaire, including their age, gender, skin sensitivity, and dietary habits.ResultsIn users between the age of 18 and 59, the prevalence of comprehensive, pigmented, and structural type of dark circles all rose with age. However, between the age of 60 and 85, the intensity of all types of dark circles diminished. Besides, vascular dark circles progressively worsen from the age of 18 to their peak at 39, and then gradually decline with age. Females typically have more pronounced black circles under their eyes than males in China. Bad eating habits, urbanization, regular cosmetics use, and sensitive skin positively correlate with severe dark circles. Vascular, comprehensive dark circles were worse in spring. Both pigmented and structural dark circles were worse in the summer. The results indicated that the intensity of dark circles was influenced by oily skin, wide pores, severe blackheads, and severe acne.ConclusionsChinese men and women differed noticeably in the prevalence of each face aging indicator and the appearance of aging dark circles. Selfies could be automatically graded and examined by artificial intelligence, which is a quick and private method for quantifying signs of facial aging and identifying major problems for different populations. Artificial intelligence would assist in the development of individualized preventive and therapeutic interventions.
Impact of artificial intelligence‐based color constancy on dermoscopical assessment of skin lesions: A comparative study
Authors: Branciforti Francesco , Meiburger Kristen M. , Zavattaro Elisa , Veronese Federica , Tarantino Vanessa , Mazzoletti Vanessa , Cristo Nunzia Di , Savoia Paola , Salvi Massimo 
Published: October 2023

AbstractBackgroundThe quality of dermoscopic images is affected by lighting conditions, operator experience, and device calibration. Color constancy algorithms reduce this variability by making images appear as if they were acquired under the same conditions, allowing artificial intelligence (AI)‐based methods to achieve better results. The impact of color constancy algorithms has not yet been evaluated from a clinical dermatologist's workflow point of view. Here we propose an in‐depth investigation of the impact of an AI‐based color constancy algorithm, called DermoCC‐GAN, on the skin lesion diagnostic routine.MethodsThree dermatologists, with different experience levels, carried out two assignments. The clinical experts evaluated key parameters such as perceived image quality, lesion diagnosis, and diagnosis confidence.ResultsWhen the DermoCC‐GAN color constancy algorithm was applied, the dermoscopic images were perceived to be of better quality overall. An increase in classification performance was observed, reaching a maximum accuracy of 74.67% for a six‐class classification task. Finally, the use of normalized images results in an increase in the level of self‐confidence in the qualitative diagnostic routine.ConclusionsFrom the conducted analysis, it is evident that the impact of AI‐based color constancy algorithms, such as DermoCC‐GAN, is positive and brings qualitative benefits to the clinical practitioner.
Phylogenetics, historical biogeography and molecular species delimitation of Chanohirata (Hemiptera: Cicadellidae: Deltocephalinae: Penthimiini)
Authors: Wang Dongming , Dietrich Christopher H. , Zhang Yalin 
Published: October 2023

AbstractThe genus Chanohirata Hayashi & Machida, including the herein synonymized monotypic genus Reticuluma Cheng & Li, is the second most speciose genus in the tribe Penthimiini after Penthimia Germar and is almost exclusively endemic to China. This study presents the first phylogeny of Chanohirata based on three mitochondrial markers (cytochrome c oxidase subunit I and II and 16S ribosomal RNA) and one nuclear fragment (28S ribosomal RNA). Reticuluma syn. n. is recovered nested within Chanohirata with strong support. Reticuluma is, therefore, proposed as a junior synonym of Chanohirata, and a new combination is proposed: Chanohirata citrana (Cheng & Li) comb. n. Molecular species delimitation analyses were conducted by combining six molecular delimitation methods with morphological evidence. The results of the species delimitation analyses confirm the status of eight described species of Chanohirata and support the recognition of three new species: Chanohirata cornicula Wang & Zhang sp. n., Chanohirata elongata Wang & Zhang sp. n. and Chanohirata serrata Wang & Zhang sp. n. Molecular dating and biogeographic analyses suggest that Chanohirata likely originated during the late Eocene in southern China. During the late Miocene to early Pleistocene, the uplift of the Himalayas and Tibetan Plateau and climatic oscillations probably triggered several dispersal and vicariance events in Chanohirata lineages, leading to most speciation events.
On the Strength and Tightness of ASME B16.5 and B16.47 Series A Standard Flanges
Authors: Bouzid Abdel-Hakim , Bouzid Sofiane , Benfriha Khaled 
Published: October 2023

Abstract
ASME flanges are extensively used in the pressure vessels and piping industry. The origin of their class and size is not based on the amount of initial bolt load they can carry nor the level of tightness they can achieve. Their PV rating does not give an indication on the level of stress they are subject to and little is known on their ability to withstand the maximum bolt stress level they can be subjected to during initial bolt-up or under operation. The integrity and leak tightness of ASME B16.5 and B16.47 series A flanges made of SA105 material need to be analyzed individually in order to identify the flange classes and sizes that are more vulnerable to the bolt stress level. This paper proposes the use of an accurate analytical model to appropriately address the integrity and leakage tightness of the complex statically indeterminate weld neck standard flange connections based on the flexibility and the elastic interaction between the different joint elements. As such, the most critical standard flanges in terms of class and size will be identified in order to avoid failure. The model is first tested and validated using finite element method simulations on different sizes of class 900 flanges. The study investigates the effect of the initial bolt preload on parameters such as flange rotation and stresses in the flange, gaskets, and bolts. The most critical size and class flanges and their highly stressed locations will be revealed.
Unsteady Flow Structure of Corner Separation in a Highly Loaded Compressor Cascade
Authors: Zhong Weibo , Liu Yangwei , Tang Yumeng 
Published: October 2023

Abstract
Corner separation is an inherently unsteady flow feature in an axial compressor cascade, and it significantly affects the aerodynamic performance of compressors. The flow field of a highly loaded compressor cascade at the Mach number of 0.59 under the moderate separation condition is simulated based on delayed detached eddy simulation. Comparisons of averaged flow field and transient flow field show that the three-dimensional corner separation flow is highly unsteady and composed of fine-scale vortex structures. The classical recognition of corner separation structures is a consequence of time-averaging. To better understand the contribution of unsteady structures to the averaged flow structures, the evolutions of flow fields in time series and the power spectrums are analyzed. A dominant periodic flow fluctuation is caused by the development of separating vortices with a characteristic frequency around 3500 Hz or at a Strouhal number of 0.75. Further, energy scales and spatiotemporal features of these dominant unsteady behaviors are analyzed using proper orthogonal decomposition and dynamic mode decomposition methods. Results show that the low-frequency behaviors mainly caused by the passage vortex at lower-span regions govern large-scale changes of separation flow in size and intensity and act with certain intermittency. The vortex developing mode around 3500 Hz prevails at higher regions affected by the concentrated shedding vortex. As the separating vortices dissipate approaching the midspan, the effect of the vortex developing mode on axial velocity fluctuation is reduced, although it dominates the pressure fluctuation with good stability in the whole passage.
Physiological Responses and Swimming-Performance Changes Induced by Altering the Sequence of Training Sets
Authors: Nikitakis Ioannis S. , Bogdanis Gregory C. , Paradisis Giorgos P. , Toubekis Argyris G. 
Published: October 2023

Purpose: Interval-training sets may be applied in a different sequence within a swimming training session. The aim of this study was to investigate the effect of different set sequences on performance and physiological responses in a training session. Methods: Twelve highly trained male swimmers performed 4 sessions in randomized order. Each session included a different combination of 2 training sets: set A–set C, set C–set A, set B–set C, or set C–set B. Set A consisted of 8 × 200 m at speed corresponding to lactate threshold (30-s recovery), set B included 8 × 100 m at maximum aerobic speed (30-s recovery), and set C included 4 × 50-m all-out swimming (2-min recovery). Performance and physiological responses (lactate concentration, pH, base excess, bicarbonate, heart rate, and heart-rate variability) were measured. Results: Performance in each set was similar between sessions irrespective of set sequence. Blood lactate, heart rate, and acid–base responses during set C were similar in all sessions, but blood lactate was higher in sets A and B during C–A and C–B sessions (P = .01). The overall blood lactate and acid–base response was higher in C–A and C–B sessions compared with A–C and B–C sessions, respectively (P = .01). Heart-rate variability in each set, separately as well as the overall session effect, did not differ and was thus independent to the set sequence applied. Conclusions: Training sessions including all-out swimming as a first set increase the magnitude of metabolic responses to the subsequent aerobic-dominated training set.
Complete genome sequence of an
Achromobacter xylosoxidans
strain H1_3_1 isolated from a hybrid biological-inorganic system reactor
Authors: Feng Xiang , Kazama Daichi , Sato Kozo , Kobayashi Hajime 
Published: October 2023

ABSTRACT

We report the complete genome of
Achromobacter xylosoxidans
strain H1_3_1, which was isolated from a reactor of a hybrid biological-inorganic system. The complete genome comprised 7,071,873 bp, including 6,428 codings, 10 rRNA, and 70 tRNA, with 67.4% G + C content.