bluuebunny/crossref_metadata_2025_split huggingface dataset:
Waterproof and ultraflexible organic photovoltaics with improved interface adhesion
Authors: Xiong Sixing , Fukuda Kenjiro , Nakano Kyohei , Lee Shinyoung , Sumi Yutaro , Takakuwa Masahito , Inoue Daishi , Hashizume Daisuke , Du Baocai , Yokota Tomoyuki , Zhou Yinhua , Tajima Keisuke , Someya Takao 
Published: February 2024

AbstractUltraflexible organic photovoltaics have emerged as a potential power source for wearable electronics owing to their stretchability and lightweight nature. However, waterproofing ultraflexible organic photovoltaics without compromising mechanical flexibility and conformability remains challenging. Here, we demonstrate waterproof and ultraflexible organic photovoltaics through the in-situ growth of a hole-transporting layer to strengthen interface adhesion between the active layer and anode. Specifically, a silver electrode is deposited directly on top of the active layers, followed by thermal annealing treatment. Compared with conventional sequentially-deposited hole-transporting layers, the in-situ grown hole-transporting layer exhibits higher thermodynamic adhesion between the active layers, resulting in better waterproofness. The fabricated 3 μm-thick organic photovoltaics retain 89% and 96% of their pristine performance after immersion in water for 4 h and 300 stretching/releasing cycles at 30% strain under water, respectively. Moreover, the ultraflexible devices withstand a machine-washing test with such a thin encapsulation layer, which has never been reported. Finally, we demonstrate the universality of the strategy for achieving waterproof solar cells.
Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages
Authors: D’Amato Rocco , Taxiarchi Chrysanthi , Galardini Marco , Trusso Alessandro , Minuz Roxana L. , Grilli Silvia , Somerville Alastair G. T. , Shittu Dammy , Khalil Ahmad S. , Galizi Roberto , Crisanti Andrea , Simoni Alekos , Müller Ruth 
Published: February 2024

AbstractCRISPR-based gene drives have the potential to spread within populations and are considered as promising vector control tools. A doublesex-targeting gene drive was able to suppress laboratory Anopheles mosquito populations in small and large cages, and it is considered for field application. Challenges related to the field-use of gene drives and the evolving regulatory framework suggest that systems able to modulate or revert the action of gene drives, could be part of post-release risk-mitigation plans. In this study, we challenge an AcrIIA4-based anti-drive to inhibit gene drive spread in age-structured Anopheles gambiae population under complex feeding and behavioural conditions. A stochastic model predicts the experimentally-observed genotype dynamics in age-structured populations in medium-sized cages and highlights the necessity of large-sized cage trials. These experiments and experimental-modelling framework demonstrate the effectiveness of the anti-drive in different scenarios, providing further corroboration for its use in controlling the spread of gene drive in Anopheles.
Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer
Authors: Li Yan , Wang Bing , Yang Wentao , Ma Fahan , Zou Jianling , Li Kai , Tan Subei , Feng Jinwen , Wang Yunzhi , Qin Zhaoyu , Chen Zhiyu , Ding Chen 
Published: February 2024

AbstractCetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab therapy with multi-course treatment, and 90 healthy controls (HCs). COL12A1, THBS2, S100A8, and S100A9 are screened as potential proteins to distinguish CRCs from HCs both in plasma and tissue validation cohorts. We identify the potential biomarkers (RRAS2, MMP8, FBLN1, RPTOR, and IMPDH2) for the initial response prediction. In a longitudinal setting, we identify two clusters with distinct fluctuations and construct the model with high accuracy to predict the longitudinal response, further validated in the independent cohort. This study reveals the heterogeneity of different biomarkers for tumor diagnosis, the initial and longitudinal response prediction respectively in the first course and multi-course cetuximab treatment, may ultimately be useful in monitoring and intervention strategies for CRC.
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Authors: Kumar Rakesh , Le Marchand Tanguy , Adam Laurène , Bobrovs Raitis , Chen Gefei , Fridmanis Jēkabs , Kronqvist Nina , Biverstål Henrik , Jaudzems Kristaps , Johansson Jan , Pintacuda Guido , Abelein Axel 
Published: February 2024

AbstractProtein misfolding can generate toxic intermediates, which underlies several devastating diseases, such as Alzheimer’s disease (AD). The surface of AD-associated amyloid-β peptide (Aβ) fibrils has been suggested to act as a catalyzer for self-replication and generation of potentially toxic species. Specifically tailored molecular chaperones, such as the BRICHOS protein domain, were shown to bind to amyloid fibrils and break this autocatalytic cycle. Here, we identify a site on the Aβ42 fibril surface, consisting of three C-terminal β-strands and particularly the solvent-exposed β-strand stretching from residues 26–28, which is efficiently sensed by a designed variant of Bri2 BRICHOS. Remarkably, while only a low amount of BRICHOS binds to Aβ42 fibrils, fibril-catalyzed nucleation processes are effectively prevented, suggesting that the identified site acts as a catalytic aggregation hotspot, which can specifically be blocked by BRICHOS. Hence, these findings provide an understanding how toxic nucleation events can be targeted by molecular chaperones.
Coupling of radiation and grain boundary corrosion in SiC
Authors: Xi Jianqi , Zhang Hongliang , Su Ranran , Wei Shuguang , Hu Xuanxin , Queylat Benoit , Kim Taeho , Couet Adrien , Szlufarska Izabela 
Published: February 2024

AbstractRadiation and corrosion can be coupled to each other in non-trivial ways and such coupling is of critical importance for the performance of materials in extreme environments. However, it has been rarely studied in ceramics and therefore it is not well understood to what extent these two phenomena are coupled and by what mechanisms. Here, we discover that radiation-induced chemical changes at grain boundaries of ceramics can have a significant (and positive) impact on the corrosion resistance of these materials. Specifically, we demonstrate using a combination of experimental and simulation studies that segregation of C to grain boundaries of silicon carbide leads to improved corrosion resistance. Our results imply that tunning of stoichiometry at grain boundaries either through the sample preparation process or via radiation-induced segregation can provide an effective method for suppressing surface corrosion.
Semi-device-independent quantum random number generator with a broadband squeezed state of light
Authors: Cheng Jialin , Liang Shaocong , Qin Jiliang , Li Jiatong , Yan Zhihui , Jia Xiaojun , Xie Changde , Peng Kunchi 
Published: February 2024

AbstractRandom numbers are a basic ingredient of simulation algorithms and cryptography, and play a significant part in computer simulation and information processing. One prominent feature of a squeezed light is its lower fluctuation and more randomness in a pair of orthogonal oriented quadratures, thus it prompts a significant application in not only quantum information and quantum precision measurement but also an excellent entropy source for true random number generation. Here we report a generation of a high-efficiency semi-device-independent quantum random number based on a broadband squeezed light, where a reliable randomness source is unnecessary and a noisy local oscillator is allowed for homodyne detection. The equivalent generation of private random bits is at a rate of 580.7 Mbps. In addition, the use of squeezed light at 1.3 μm enables the transmission of entropy sources and local oscillators at the metropolitan scale, thus expanding the potential applications of quantum random number generators based on non-classical state of light.
Comparative analysis of breast cancer characteristics in young premenopausal and postmenopausal women in Ghana
Authors: Bosompem Kingsley , Yorke Joseph , Buckman Tonnies Abeku , Brenu Samuel Gyasi , Nyantakyi Michael , Aitpillah Francis Somiah-Kwaw , Kyei Ishmael , Adinku Michael Ofoe , Yorke Dennis Afful , Obirikorang Christian , Acheampong Emmanuel 
Published: February 2024

AbstractBreast cancer is increasingly common among young women in Ghana. BCa is heterogeneous with unique traits that impact causes, prognostic, and predictive outcomes of patients before and after menopause. However, limited evidence exists on differences between young premenopausal (YPM) and postmenopausal cases in Ghana. This study compared breast tumour characteristics between YPM women (under 35 years) and postmenopausal women. We conducted a prospective cross-sectional study involving 140 BCa-diagnosed women at the Breast Care Clinic of Komfo Anokye Teaching Hospital (KATH), Kumasi from November 2019 to June 2021. Thirty-one (22.1%) of participants were YPM and 109 (77.9%) were postmenopausal. The median ages for YPM and postmenopausal were 32.0 (range: 25.0–35.0) and 57.0 (48.0–86.0) respectively. Invasive carcinoma was the most common histological type (97.1%). Left tumour location was the most frequent in both groups (51.6% for YPM and 51.8% for postmenopausal). Lumps detected were frequently in the outer upper quadrant in both groups (61.3% and 56.0%). The majority of the YPM women (80.7%) and postmenopausal women (87.0%) had stage III and IV diseases. Most YPM (64.5%) and postmenopausal women (64.4%) exhibited triple-negative breast cancer (TNBC). Both YPM 13 (56.6%) and postmenopausal participants 40 (56.3%) exhibited a predominantly partial response to neo-adjuvant chemotherapy but YPM women (21.7%) experienced disease progression than the postmenopausal women (12.7%). The study highlights consistent tumour characteristics and advanced clinical stages at diagnosis in both groups with a higher prevalence of TNBC. TNBC and HER2+ subtypes respond better to Anthracycline-based neoadjuvant chemotherapy. Establishing Breast Care Clinics in district and regional hospitals for early detection is crucial and further studies are warranted to understand the higher TNBC prevalence in black Africans and re-evaluate breast education programs to address the persistently late presentations.
Security issues of the gold industry chain based on smart blockchain in the context of the Internet of Things
Authors: Zheng Jifei , Wang Guisen , Zhang Yuhan , Chen Lei , Li Xiao , Zhang Shouting 
Published: February 2024

AbstractThe purpose is to solve the safety production and management problems of the gold Industrial Chain and give early warning of the safety situation of the gold Industrial Chain. According to the theory of industrial chain security governance and the basic situation of the gold Industrial Chain, this work establishes a gold Industrial Chain model based on smart blockchain and system dynamics (SD), and discusses the application of the gold Industrial Chain in the Internet of Things (IoT) environment. The overall goal of the application of IoT technology to the safety management of intelligent gold mines is to take the gold mine production demand as the driving force. The digitalization of production, electromechanical, safety, dispatching, and other information realizes intelligent digital perception, assists decision-making, guides the safety management of gold mining operations, continuously improves the operation efficiency of the gold mining industry, and drives the development of the industry. Finally, it takes the resource reserve of China’s gold industry from 2011 to 2021 as the research data introduces the weighting method to assess the security situation of China’s gold Industrial Chain from 2011 to 2021. The safety performance of China's environmental industry chain is evaluated through the detailed introduction of the basic information of the gold Industrial Chain. The result shows that the security situation of China’s gold Industrial Chain from 2011 to 2021 shows an overall growth trend, 88.42% higher than in 2014. The security situation of China’s gold Industrial Chain from 2011 to 2021 positively impacted the opening of the domestic gold market and entering the international gold market, improving the security level of China’s gold Industrial Chain. In this work, a gold Industrial Chain security model based on smart blockchain and SD is established to solve the safety problem of the gold Industrial Chain, which can improve the safety level of the gold industry and promote its sustainable development.
Spatial factors influencing the pain-ameliorating effect of CT-optimal touch: a comparative study for modulating temporal summation of second pain
Authors: Meijer Larissa L. , Baars Wouter , Chris Dijkerman H. , Ruis Carla , van der Smagt Maarten J. 
Published: February 2024

AbstractRecent studies show that CT-optimal touch, gentle slow stroking of the skin, can reduce pain. However, much is unknown regarding the factors influencing its pain-ameliorating effect, such as tactile attention and touch application site. The current study investigates in 36 healthy individuals, whether CT-optimal touch can reduce temporal summation of second pain (TSSP) compared to CT non-optimal touch and tapping the skin. TSSP refers to activation of the C-nociceptors; by stimulating these fibers a burning and/or tingling sensation can be elicited. All participants underwent three conditions on both the contralateral and ipsilateral side of pain induction. The results show that tapping the skin did not reduce TSSP, meaning that pain reduction through touch cannot be explained by tactile attention effects. CT non-optimal touch only reduced TSSP when applied on the ipsilateral side. Importantly, CT-optimal touch effectively reduced TSSP when applied on the contralateral or ipsilateral side. Furthermore, CT-optimal touch was more effective in reducing TSSP compared to CT non-optimal touch and Tapping. This study shows that that CT-optimal touch can reduce TSSP and this effect appears to be independent of touch application site, which is highly relevant for implementing CT-optimal touch as a treatment.
Application solutions of highway freight information systems based on quantum communication
Authors: Tang Wenliang , Gao Yifan 
Published: February 2024

AbstractTo improve the security of data transmission in the highway freight information system, this study is an application plan for the highway freight information system based on quantum communication. This solution is based on quantum communication technology to encrypt and transmit key sensitive data[1]; it realizes unified management of quantum keys through the quantum key cloud terminal and provides key services for the highway freight information system; it realizes access to the system through the quantum key cloud service platform. The secure use of mobile terminal quantum keys improves the overall security of the road freight information system. This scheme uses the quantum encryption key generated only once, effectively protecting the entire system's security. The quantum key management server and quantum key cloud platform defined in this plan manage terminals and quantum keys respectively, and jointly produce and distribute quantum keys with the help of other hardware facilities and software to provide secure transmission of key information.
Impact of sensitization and ABO blood types on the opportunity of deceased-donor kidney transplantation with prolonged waiting time
Authors: Lee Jin Hyeog , Koo Tai Yeon , Lee Jung Eun , Oh Kook Hwan , Kim Beom Seok , Yang Jaeseok 
Published: February 2024

AbstractThe waiting time to deceased-donor kidney transplantation (DDKT) is long in Asian countries. We investigated the impact of sensitization and ABO blood type (ABO) on DDKT opportunity using two Korean cohorts: a hospital cohort from two centers and a national database. The impact of panel reactive antibody (PRA) based on the maximal PRA% and ABO on DDKT accessibility was analyzed using a competing risks regression model. In the hospital cohort (n = 4722), 88.2%, 8.7%, and 3.1% of patients belonged to < 80%, 80–99%, and ≥ 99% PRA groups, respectively, and 61.1%, 11.6%, and 27.3% belonged to A or B, AB, and O blood types, respectively. When PRA and ABO were combined, PRA < 80%/A or B and 80 ≤ PRA < 99%/AB had fewer DDKT opportunities (median, 12 years; subdistribution hazard ratio [sHR], 0.71) compared with PRA < 80%/AB (median, 11 years). Also, PRA < 80%/O, 80 ≤ PRA < 99%/A or B, and PRA ≥ 99%/AB had a much lower DDKT opportunity (median, 13 years; sHR, 0.49). Furthermore, 80 ≤ PRA < 99%/O and PRA ≥ 99%/non-AB had the lowest DDKT opportunity (sHR, 0.28). We found similar results in the national cohort (n = 18,974). In conclusion, an integrated priority system for PRA and ABO is needed to reduce the inequity in DDKT opportunities, particularly in areas with prolonged waiting times.
The jump in global temperatures in September 2023 is extremely unlikely due to internal climate variability alone
Authors: Rantanen Mika , Laaksonen Ari 
Published: February 2024

AbstractSeptember 2023 was the warmest September on record globally by a record margin of 0.5 °C. Here we show that such a record-breaking margin is an extremely rare event in the latest generation of climate models, making it highly unlikely (p ~ 1%) that internal climate variability combined with the steady increase in greenhouse gas forcing could explain it. Our results call for further analysis of the impact of other external forcings on the global climate in 2023.
The emergence of urban heat traps and human mobility in 20 US cities
Authors: Huang Xinke , Jiang Yuqin , Mostafavi Ali 
Published: February 2024

AbstractUnderstanding the relationship between spatial structures of cities and environmental hazard exposures is essential for urban health and sustainability planning. However, a critical knowledge gap exists in terms of the extent to which socio-spatial networks shaped by human mobility exacerbate or alleviate urban heat exposures of populations in cities. In this study, we utilize location-based data to construct human mobility networks in twenty metropolitan areas in the U.S. The human mobility networks are analyzed in conjunction with the urban heat characteristics of spatial areas. We identify areas with high and low urban heat exposure and evaluate visitation patterns of populations residing in high and low urban heat areas to other spatial areas with similar and dissimilar urban heat exposure. The results reveal the presence of urban heat traps in the majority of the studied metropolitan areas, wherein populations residing in high-heat exposure areas primarily visited other high-heat exposure zones. Specifically, cities such as Los Angeles, Boston, and Chicago were particularly pronounced as urban heat traps. The results also show a small percentage of human mobility to produce urban heat escalation and heat escapes. The findings from this study provide a better understanding of urban heat exposure in cities based on patterns of human mobility. These findings contribute to a broader understanding of the intersection of human network dynamics and environmental hazard exposures in cities to inform more integrated urban design and planning to promote health and sustainability.
A climatology of weather-driven anomalies in European photovoltaic and wind power production
Authors: Ho-Tran Linh , Fiedler Stephanie 
Published: February 2024

AbstractWeather causes extremes in photovoltaic and wind power production. Here we present a comprehensive climatology of anomalies in photovoltaic and wind power production associated with weather patterns in Europe considering the 2019 and potential 2050 installations, and hourly to ten-day events. To that end, we performed kilometer-scale numerical simulations of hourly power production for 23 years and paired the output with a weather classification which allows a detailed assessment of weather-driven spatio-temporal production anomalies. Our results highlight the dependency of low-power production events on the installed capacities and the event duration. South-shifted Westerlies (Anticyclonic South-Easterlies) are associated with the lowest hourly (ten-day) extremes for the 2050 (both) installations. Regional power production anomalies can differ from the ones in the European mean. Our findings suggest that weather patterns can serve as indicators for expected photovoltaic and wind power production anomalies and may be useful for early warnings in the energy sector.
Status, challenges, and promises of data‐driven battery lifetime prediction under cyber‐physical system context
Authors: Liu Yang , Chen Sihui , Li Peiyi , Wan Jiayu , Li Xin 
Published: February 2024

AbstractEnergy storage is playing an increasingly important role in the modern world as sustainability is becoming a critical issue. Within this domain, rechargeable battery is gaining significant popularity as it has been adopted to serve as the power supplier in a broad range of application scenarios, such as cyber‐physical system (CPS), due to multiple advantages. On the other hand, battery inspection and management solutions have been constructed based on the CPS architecture in order to guarantee the quality, reliability and safety of rechargeable batteries. In specific, lifetime prediction is extensively studied in recent research as it can help assess the quality and health status to facilitate the manufacturing and maintenance. Due to the aforementioned importance, the authors aim to conduct a comprehensive survey on the data‐driven techniques for battery lifetime prediction, including their current status, challenges and promises. In contrast to existing literature, the battery lifetime prediction methods are studied under CPS context in this survey. Hence, the authors focus on the algorithms for lifetime prediction as well as the engineering frameworks that enable the data acquisition and deployment of prediction models in CPS systems. Through this survey, the authors intend to investigate both academic and practical values in the domain of battery lifetime prediction to benefit both researchers and practitioners.
A two‐stage, four‐layer robust optimisation model for distributed cooperation in multi‐microgrids
Authors: Rong Haobo , Wang Jianhui , Kuang Honghai 
Published: February 2024

AbstractAs the integration of microgrids (MG) and energy storage continues to grow, the need for efficient distributed cooperation between MGs and common energy storage (CES) becomes paramount. A robust optimisation model for the distributed cooperation of MG‐CES is presented, taking into account distributed generation under uncertainty. The proposed model follows a two‐stage, four‐layer ‘min‐min‐max‐min’ structure. In the first stage, the initial layer ‘min’ addresses the distributed cooperation problem between MG and CES, while the second stage employs ‘min‐max‐min’ to optimise the scheduling of MG. To enhance the solution process and expedite convergence, the authors introduce a column‐constrained generation algorithm with alternating iterations of U and D variables (CCG‐UD) specifically designed for the three‐layer structure in the second stage. This algorithm effectively decouples subproblems, contributing to accelerated solutions. To tackle the convergence challenges posed by the non‐convex MG‐CES model, the authors integrate the Bregman alternating direction method with multipliers (BADMM) with CCG‐UD in the final solution step. Real case tests are conducted using three zone‐level MGs to validate the efficacy of the proposed model and methodology. The results demonstrate the practical utility and efficiency of the developed approach in addressing distributed cooperation challenges in microgrid systems with energy storage.