bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPACT OF PARAVERTEBRAL BLOCKADE ON THE COURSE OF EARLY POSTOPERATIVE PERIOD FOLLOWING SURGICAL INTERVENTION FOR LUNG MALIGNANCIES UNDER INHALED SEVOFLURANE ANESTHESIA
Authors: Suprun A. S. 
Published: November 2023

The aim of the study is to investigate the impact of paravertebral blockade on the quality of anti-stress protection of general inhalation anaesthesia based on sevoflurane during operations in patients with lung malignancy. Material and methods. We examined 60 individuals of an average age 55±5.6 years, whose physical status was assessed as class II – III according to the ASA classification. The patients underwent open surgical procedures, including frontal or pneumonectomy, or partial lung resection. The patients were divided into 2 groups depending on the method of anaesthesia: SF group (sevoflurane) (n = 29) received inhaled anaesthesia with sevoflurane; SF+PVB group (n = 31) received the combination of inhaled anaesthesia with PVB. The following indicators were assessed: time of the first administration of the analgesic after surgery, pain intensity by the visual analogue scale (VAS), perfusion systemic pressure (PST), cardiac index (CI), oxygen content in arterial and venous blood, blood lactate levels, indicators of circulatory energy efficiency, cortisol, insulin and HOMA index levels. Indicators were recorded before the surgical operation, at the wake-up stage, on the 1st and 5th days following the operation. Results. In the SF+PVB group, the intensity of pain in the postoperative period was significantly lower than in the SF group. In the SF+PVB group, there was no necessity for administering narcotic analgesics on the first day, while in the SF group, the dose of morphine was 0.27±0.04 mg/kg∙day, the first administration was performed 65.5±10.3 minutes after surgery. CI during surgery and in a day was significantly higher in the SF+PVB group, and the arteriovenous difference in oxygen content was significantly lower. The energy efficiency of blood circulation at the same stages was significantly higher in the SF+PVB group. In the same group, there was a significantly lower concentration of markers of stress responses (cortisol levels and HOMA index). Conclusions. The use of paravertebral blockade under the general anaesthesia based on sevoflurane during operations in patients with lung malignancies contributes to a significant reduction in the pain intensity in the postoperative period; eliminates the need to use narcotic analgesics; provides significantly more stable hemodynamics and significantly more adequate oxygen supply during the operation and in the postoperative period; significantly reduces the intensity of stress reactions as well as significantly improves the energy efficiency of blood circulation.
A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images
Authors: Ibrahim Yehia , Xie Jianyang , Macerollo Antonella , Sardone Rodolfo , Shen Yaochun , Romano Vito , Zheng Yalin 
Published: November 2023

Background: Traditional methods for diagnosing dementia are costly, time-consuming, and somewhat invasive. Since the retina shares significant anatomical similarities with the brain, retinal abnormalities detected via optical coherence tomography (OCT) and OCT angiography (OCTA) have been studied as a potential non-invasive diagnostic tool for neurodegenerative disorders; however, the most effective retinal changes remain a mystery to be unraveled in this review. Objective: This study aims to explore the relationship between retinal abnormalities in OCT/OCTA images and cognitive decline as well as evaluating biomarkers’ effectiveness in detecting neurodegenerative diseases. Methods: A systematic search was conducted on PubMed, Web of Science, and Scopus until December 2022, resulted in 64 papers using agreed search keywords, and inclusion/exclusion criteria. Results: The superior peripapillary retinal nerve fiber layer (pRNFL) is a trustworthy biomarker to identify most Alzheimer’s disease (AD) cases; however, it is inefficient when dealing with mild AD and mild cognitive impairment (MCI). The global pRNFL (pRNFL-G) is another reliable biomarker to discriminate frontotemporal dementia from mild AD and healthy controls (HCs), moderate AD and MCI from HCs, as well as identifing pathological Aβ42/tau in cognitively healthy individuals. Conversely, pRNFL-G fails to realize mild AD and the progression of AD. The average pRNFL thickness variation is considered a viable biomarker to monitor the progression of AD. Finally, the superior and average pRNFL thicknesses are considered consistent for advanced AD but not for early/mild AD. Conclusions: Retinal changes may indicate dementia, but further research is needed to confirm the most effective biomarkers for early and mild AD.
Linking Cognitive Impairment with Amyloid-β Accumulation in Alzheimer’s Disease: Insights from Behavioral Tests and FTIR Spectroscopy
Authors: Gaber Heba Ahmed , Aly Eman Mohamed , Mohamed Eman Saad , Elfoly Marwa , Rabie Mostafa Adel , Talaat Mona Salah , El-Sayed El-Sayed Mahmoud 
Published: November 2023

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder that progresses over time. Fourier Transform Infrared Spectroscopy (FTIR) analysis gives identification of the main metabolic changes that happen during neurodegeneration, by monitoring biochemical and molecular structure alterations that can help in AD diagnosis or treatment approach. Objective: The aim of the present work is to assess AD hallmarks in molecular structure of retina and monitor accumulation of amyloid beta42(Aβ42) in brain and retina during disease progression. Methods: AD induced in rats by Aluminum Chloride (AlCl3). Retinal molecular structure during disease progression for 2,4,6 and 8 weeks was assessed by Fourier-transform infrared spectroscopy (FTIR) and the incidence of the disease was confirmed by a behavioural assessment; the Morris Water Maze test. Aβ42 levels in the brain and retina were also measured. Results: The results indicated that cognitive impairment starting from 6 weeks of AlCl3 administration. Retinal concentration of Aβ42 was significant increase ( p < 0.05) from 2 weeks that precedes the observed increase of Aβ42 in the brain which appeared after 4 weeks of AlCl3 administration. Multivariate principal component analysis discovers that the variance noticed in the infrared spectra due to AD condition and it is time dependent for progression of the disease. Conclusions: The accumulation of Aβ42 is a sensitive early biomarker in retina for AD. FTIR analysis of the retina revealed changes in hydrogen bond formation or destruction, alterations in lipid chain length and branching accompanied by depleted lipid content and carbonization, as well as degeneration of the retinal tissue due to AD.
Norms for the Triana Test: A Story Recall Test Based on Emotional Material
Authors: Luque-Tirado Andrea , Montiel-Herrera Fátima , Maestre-Bravo Rebeca , Barril-Aller Claudia , García-Roldán Ernesto , Arriola-Infante José Enrique , Sánchez-Arjona María Bernal , Rodrigo-Herrero Silvia , Vargas-Romero Juan Pedro , Franco-Macías Emilio 
Published: November 2023

Background: The “Triana Test” is a novel story recall test based on emotional material with demonstrated accuracy in diagnosing mild cognitive impairment patients. Objective: This study aims to obtain normative data for the “Triana Test”. Methods: A normative study was conducted at a university hospital in Spain. Partners of patients were systematically recruited if eligible (age ≥50, no memory complaints, and a total TMA-93 score at or above the 10th percentile). The “Triana Test” was administered and scored. For developing the normative data, a regression-based method was followed. Results: The final sample included 362 participants (median age = 66, range = 50–88; 64.9% females). A model including age and educational level better predicted the total scores. Combinations of these variables resulted in different 10th percentile scores. Conclusions: Norms for using the “Triana Test” are now available. The provided cutoffs for the 10th percentile will aid in the diagnosis of prodromal Alzheimer’s disease.
Exogenous Oxytocin Administration Restores Memory in Female APP/PS1 Mice
Authors: Koulousakis Philippos , Willems Emily , Schepers Melissa , Rombaut Ben , Prickaerts Jos , Vanmierlo Tim , van den Hove Daniel 
Published: November 2023

Background: Current treatment options for Alzheimer’s disease (AD) are limited, inefficient, and often have serious side effects. Oxytocin is a neuropeptide implicated in a variety of central processes, such as social and reproductive behaviors. Among others, it has garnered attention in various domains of psychiatric research, while its role in the development and course of neurodegenerative disorders like AD is rather unknown. Objective: This study aimed to investigate the role of exogenous oxytocin administration on memory, specifically in view of AD, as a potential novel treatment option. Methods: We describe a novel treatment approach by using a relatively low dose of long-term intranasal oxytocin treatment, to restore memory deficits in female APPswePS1dE9 mice. Results: Female APPswePS1dE9 mice treated with oxytocin showed increased spatial memory performance in the object location task and improved working memory in the Y-Maze, while indicating decreased sociability. Conclusions: These results indicate that oxytocin is able to reverse acquired cognitive deficits in female APPswePS1dE9 mice.
Andre Wainen's Rhapsody for Alto Saxophone and Orchestra or Piano in the Representation of the "New Academicism" of Post-Avant-Garde Art
Authors: Li Yuxuan 
Published: November 2023

The purpose of the research is to understand the stylistic quality of A. Waingnein's Rhapsody in the direction of the musical-instrumental specificity of the post-post-avant-garde stage of music, which we call "new academicism" within the post-avant-garde stratum of creativity. As a methodological basis, we put forward the intonation approach of the B. Asafiev school in Ukraine, as it developed in the works of D. Androsova, O. Markova, O. Muravska, with an emphasis on hermeneutic and stylistic-comparative analysis, as well as relying on the developments of the post-post-avant-garde in works Drozdovskyi, I. Navoieva, and others. Scientific novelty is determined, firstly, by the primacy in Ukrainian and Chinese musicology of the analysis of the named work by A. Waingnein, and secondly, by the originality of theoretical conclusions regarding the "new academicism" within the framework of post-avant-garde stylistics. Conclusions. The post-post-avant-garde stage of the development of art from the 2000s to the 2010s emphasises, despite the playful stylistic eclecticism of post-avant-garde creativity, the revival of the pathos beginning indicative of classical art, which tends to put forward the popular layer as a pathos-accentuation of expression in the work. Waingnein's academic approach unfolds the traditionalist stylistic dimensions inherited from the last century, emphasising as culminating "surges" (the absence of dramatic antitheticity in the composition "relieves" the tension of the dramaturgically essential) genre fragments of the work's thematics, which have been tested by the popular musical layer.
Keywords: musical genre, style in music, rhapsody, post-avant-garde, "new academicism", musical instrumentalism.
Interaction of Cultural Components in the Musical Art of China in the Context of Globalisation Influences
Authors: Liu Junyi 
Published: November 2023

The purpose of the article is to analyse the interaction of Chinese and global elements in music and to highlight how Chinese actively construct their identity through musical discourse. The research employs methods of literary source analysis, conceptual analysis, and methods of cultural analysis to reveal the role of music in the construction of cultural identity. Special attention is given to the analysis of cultural transformations, dynamics of interaction between Chinese and global cultural elements in the field of musical art. The scientific novelty lies in studying the interaction of different cultural components in the musical context of China in the conditions of globalisation. Conclusions. The research results allow us to define the role of music in the formation and preservation of cultural identity in the conditions of variability and cultural interaction. Understanding the essence of music and studying the achievements of their predecessors, the Chinese community employs historically and culturally rooted ideologies and practices to guide their musical discourse. It is argued that Chinese music can acoustically express their national identity, even if the sounds include elements that have external origins or are associated with other cultures. Music emerges as a platform where different nationalities can effectively communicate both among themselves and with representatives of other cultures, expressing their personal and authentic identity.
Keywords: Chinese music, cultural identity, globalisation, musical dialogue, cultural components.
SELEKSI CALON PENERIMA BANTUAN SOSIAL MENGGUNAKAN METODE SIMPLE ADDITIVE WEIGHTING (SAW)
Authors: Rohmatulloh Muhamad Ikhsanuddin  
Published: November 2023

Bantuan sosial merupakan upaya pemerintah bertujuan untuk mewujudkan keadilan social bagi seluruh rakyat Indonesia berdasarkan amanat Undang-Undang Dasar 1945. Upaya pemerintah dalam memberikan bantuan tentunya memiliki keterbatasan anggaran sehingga kuota jumlah penerimanya dibatasi. Keterbatasan inilah mendasari perlunya seleksi calon penerima bantuan dengan cara memberikan survey dengan pertanyaan sebagai kriteria dalam seleksi tersebut sesuai dengan tingkat prioritas. Penentuan calon penerima bantuan biasanya membuat pemangku kepentingan memiliki keterbatasan dalam menentukan quota terebut sehingga diperlukan system pendukung keputusan untuk membantu menentukan rekomendasi calon penerima bantuan social dengan perangkingan kandidat sesuai prioritas kriteria. Metode simple additive weight membantu dalam memecahkan masalah sesuai dengan tingkat prioritas kriteria yang telah ditentukan sehingga menghasilkan rangking rekomendasi calon penerima bantuan.
DAMPAK PEMBELAJARAN DARING TERHADAP PERKEMBANGAN ANAK USIA PRA SEKOLAH: LITERATURE REVIEW
Authors: Mulyana Dede Sri , Idah Faridah  
Published: November 2023

Pendahuluan : Pembelajaran adalah suatu upaya yang dilakukan oleh seseorang guru atau pendidik untuk membelajarkan siswa yang belajar. Pembelajaran daring merupakan pembelajaran yang berlangsung di dalam jaringan dimana pengajar dan yang diajar tidak bertatap muka secara langsung. Tujuan: untuk mengetahui dampak pembelajaran daring terhadap perkembangan anak usia prasekolah berdasarkan penelitian - penelitian yang sudah dilakukan sebelumnnya. Metode: Penelitian yang di gunakan yaitu literature review menggunakan tiga data base yaitu menggunakan Pubmed, Cochrane, dan Scholar untuk menemukan artikel sesuai kriteria inklusi dan ekslusi kemudian dilakukan review. Desain penelitian yaitu cross sectional, dengan tahun pencarian 2018-2022. Hasil: adanya dampak yang signifikan dari hasil pembelajaran daring terhadap perkembangan anak usia prasekolah, diantaranya yaitu adanya penurunan terhadap perkembangan psikososial, kognitif dan kecerdasan emosional anak usia prasekolah. Kesimpulan: Diharapkan perawat maupun tenaga medis lainnya dapat membantu
Penerapan Model Delikan dan CTL untuk Meningkatkan Prestasi Belajar Pancasila dan Pengembangan Karakter Mahasiswa PGSD FKIP Unib
Authors: Juarsa Osa Juarsa , Djuwita Puspa Djuwita 
Published: November 2023

Penelitian ini bertujuan menganalisis peningkatan prestasi belajar Pancasila serta ketertanaman karakter pada diri mahasiswa dan mendekripsikan strategi yang paling tepat dilakukan melalui pembelajaran model delikan, dan CTL. Metode pendekatan menggunakan kaji tindak latar kelas atau clasroon action reserch . Penelitian ini dilaksanakan di kelas 1A PGSD FKIP UNIB TA 2019/2020 dengan menggunakan sistem siklus. Setiap siklusnya terdiri atas beberapa tahapan yaitu: (1) Perencanaan (planning); (2) Pelaksanaan tindakan (action); (3) Pengamatan (observation); dan (4) Refleksi (reflection), Metode pengumpulan data yang digunakan adalah Observasi ,Tes Hasil Belajar, Wawancara. Metode Analisis Data dengan penilaian acuan patokan (PAP), analisa data hasil sebelum dan sesudah perlakuan/treatment digunakan statistik mean serta data yang tidak bisa dianalisa dengan rumus statistik akan dinarasikan kemudian diberi argumen. Hasil penelitian menunjukkan bahwa prestasi belajar mahasiswa dapat ditingkatkan dari rata-rata hasil belajar kelas 66,60 menjadi 83 serta terjadi ketertanaman karakter kedalam diri mahasiswa. Rata-rata skor hasil ceklis pengamatan perubahan karakter mahasiswa atas nilai-nilai yang terkandung dalam materi pembelajaran pada siklus 2 jauh lebik daripada pada siklus 1, dimana rata-rata skor pada siklus 1 sebesar 66,25 dan rata-rata skor pada siklus 2 sebesar 80,06. Peningkatan ini terjadi setelah mahasiswa diajak menggali nilai yang terkandung dalam materi yang dipelajari juga diajak untuk mamantau keterbiasaan melakukan, dan mengkaji dengan cara mengemukakan pertanyaan apa, mengapa, bagaimana, siapa, dimana dan kapan dilakukan serta kemana harus dipertanggungjawabkan serta dilakukan secara terus menerus.
Sistem Informasi Rekam Medis Asesmen Kebidanan Berbasis Web Menggunakan Metode Rapid Aplication Development (RAD)
Authors: Fajri Wahyu , Hardiani Tikaridha 
Published: November 2023

Pihak RS PKU Muhammadiyah Gamping – Yogyakarta memiliki tujuan agar proses yang berkaitan dengan aspek administrasi dan dokumentasi segera didigitalisasikan. Petugas rekam medis di RS PKU Muhammadiyah Gamping – Yogyakarta khususnya pada bidang asesmen kebidanan masih menggunakan sistem manual dalam melakukan pengelolaan dan pembuatan laporan data pasien. Hal ini menyebabkan terjadinya keterlambatan penyampaian laporan data harian pasien dan berdampak pada penurunan pelayanan pada pasien. Untuk mengatasi hal tersebut, maka dibutuhkan perangkat pencatatan secara digital yaitu sistem informasi rekam medis berbasis web. Metode yang digunakan penulis dalam pengembangan sistem informasi ini yaitu menggunakan model RAD atau Rapid Aplication Development. Platform pemrograman menggunakan framework CodeIgniter 3 dan Bootstrap 4.6. Pengelolaan database menggunakan MySQL. Tujuan dari pembuatan sistem informasi rekam medis ini untuk mempermudah pengelolaan data pasien yang meliputi data pendaftaran pasien, data pencatatan rekam medis pasien, dan pengumpulan master data pasien. Sistem rekam medis ini diharapkan dapat meningkatkan pelayanan asesmen kebidanan.
Penerapan Metode Markerless Based Augmented Reality Rumah Fatmawati Sebagai Destinasi Wisata Unggulan Kota Bengkulu
Authors: Darnita Yulia , Toyib Rozali 
Published: November 2023

Sosok Ibu Fatmawati sangat dikenal sebagai ibu pertama dan penjahit bendera sangsaka merah putih sebagai bendera negara Indonesia, menjadi pendamping Ir.Soekarno sebelum kemerdekaan sampai akhir ayatnya, sesorang dinilai dari keluarga mana dibesarkan dan tempat tinggalnya sebagai cerminan seseorang khususnya rumah dan sudah ada upaya untuk memperkenal rumah tempat tinggal Ibu Fatmawati dengan melalui media informasi berupa selebaran/brosur, buku, paduan wisata dan buku, tetapi ini ini hanya menjangkau kalangan tertentu saja. Penggunaan teknologi Augmented Reality yang bersifat real time dengan metode markerless based yang disematkan di Smartphone Android memungkinkan banyak orang bisa mendownload aplikasi ini dan dapat mengeksplorasi benda-benda bersejarah yang ada di rumah sebelum mereka mengambil keputusan untuk berkunjung. Berdasarkan hasil pengujian pembuatan gambar 3 D menggunakan metode markerless ini lebih efektif dibandingkan dengan metode marker based dimana keberhasilannya lebih tinggi, jarak tidak menjadi masalah yang berarti serta penggunaannya tidak tergantung dari jenis handphone yang khusus.Kata Kunci: ibu fatmawati, rumah, augmented reality, metode markerless based, smartphone android
Individual and combined associations of estimated pulse wave velocity and systemic inflammation response index with risk of stroke in middle-aged and older Chinese adults: a prospective cohort study
Authors: Xu Man , Wang Wenqiang , Chen Ruoling , Zhou Li , Hu Hui , Qiao Guiyuan , Wang Ling , Liu Xuezhen , Wang Qiuhong , Ai Yating , Ren Hairong , Hu Ping 
Published: November 2023

Background and aimsEstimated pulse wave velocity (ePWV) and systemic inflammatory response index (SIRI) have been recently investigated as a marker of arterial stiffness and a novel systemic inflammatory indicator. This study aims to examine the independent and combined association of ePWV and SIRI with incident stroke and its subtypes.MethodsData of the Dongfeng-Tongji cohort study was analyzed for 9,154 middle-aged and older adults, who were free of cardiovascular disease and cancer and were followed up to document incident stroke. But their association with incident stroke events and its subtypes have not been well studied. Multivariable adjusted Cox regression models were used to determine the independent and combined association of ePWV and SIRI with incident stroke events.ResultsOver a 7.22-year follow-up, the cohort documented 491 stroke cases (387 ischemic stroke and 104 hemorrhagic stroke). The multivariate adjusted model showed that with each one-unit increase in the level of ePWV, the corresponding hazard ratios (HRs) (95% CI) for total stroke, ischemic stroke, and hemorrhagic stroke were 1.53 (95% CI, 1.23–1.90), 1.42 (95% CI, 1.11–1.83), and 1.92 (95% CI, 1.21–3.03), respectively. Similarly, with each one-unit increase in log-transformed levels of SIRI, the corresponding HRs (95% CI) for total stroke, ischemic stroke, and hemorrhagic stroke were 1.23 (95% CI,1.04–1.47), 1.16 (95% CI, 0.96–1.41), and 1.52 (95% CI, 1.05–2.20), respectively. There appeared to be a combined effect of ePWV and SIRI on stroke; Participants with high levels of both ePWV and SIRI had a higher risk of total stroke and hemorrhagic stroke, with multiple adjusted HR of 2.43 (95% CI, 1.09–5.42). Additionally, the incorporation of ePWV in addition to traditional cardiovascular risk factors significantly improved the predictive accuracy for total stroke with C statistic increased from 0.684 (95% CI, 0.661–0.707) to 0.687 (95% CI, 0.664–0.710; x2 = 6.65; p for difference = 0.010), and (suggestively) for ischemic stroke with C statistic increased from 0.684 (95% CI, 0.659–0.71) to 0.691(95% CI, 0.666–0.717; x2 = 3.13, p for difference = 0.077), respectively.ConclusionsThe presence of both high ePWV and SIRI individually, as well as together, was found to be associated with an increased incidence of stroke. The combined stroke risk assessment using these two indicators could potentially improve non-invasive assessment and treatment strategies for high-risk patients, as these indicators are easily accessible in clinical practice.