bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary artery lesions in Takayasu arteritis
Authors: Dzhus Marta , Mostbauer Halyna 
Published: January 2024

IntroductionTakayasu arteritis (TAK) is a granulomatous inflammation of vessels of large diameter, mainly affecting the aorta and its proximal branches, which is more common in young women.
The incidence of coronary artery disease in TAK is unknown and not sufficiently studied.Material and MethodsA literature review was performed for the period 2003 to 2023 using a search of the PubMed and Scopus scientific databases. We used the following key words to search the academic journal data-bases: “Takayasu arteritis”, “coronary angiography”, “myocardial revascularization”, “coronary artery disease”, “angina pectoris”, and “myocardial infarction”.ResultsThe analysis of studies showed that coronary artery lesions (CAL) in TAK are not uncommon, being identified particularly in children and young individuals. Pathology of the coronary arteries increases the morbidity and mortality of TAK patients. In TAK, the ostia and proximal segments of the coronary arteries are more frequently affected, presenting as stenosis or occlusion with the development of stable coronary artery disease, unstable coronary artery disease, acute myocardial infarction, and sudden death. The diagnosis of TAK and coronary artery pathology is often complicated due to non-specific manifestations and frequently the absence of symptoms. The treatment of patients with TAK with CAL is challenging and requires both pharmacological therapy and interventional or surgical methods of myocardial revascularization.ConclusionsTakayasu arteritis is a more prevalent cause of CAL development, especially in young patients, than previously believed, and cardiovascular death due to CAL is not rare. Early diagnosis of TAK with CAL, particularly occlusion or hemodynamically significant stenosis, and the prompt initiation of appropriate treatment prevent dangerous complications, reduce mortality, and improve prognosis.
Newly developed cardiovascular risk factors in rheumatoid arthritis patients initiating biologic treatment
Authors: Zaręba Wojciech , Krawiec Pior , Banaszkiewicz Małgorzata , Batko Krzysztof , Gołąb Aleksandra , Plicner Dariusz , Żuber Zbigniew , Batko Bogdan 
Published: January 2024

IntroductionRheumatoid arthritis (RA) is a risk factor (RF) for cardiovascular (CV) disease, a leading cause of mortality in RA patients.Material and methodsConsecutive records of RA patients with high disease activity screened upon biologic therapy initiation were reviewed between January 2001 and 2018. Patients with at least 6-month follow-up and baseline disease activity scores were enrolled (n = 353) and stratified into manifest CV disorder (“overt CVD”), any traditional CV risk factor (“atCVrisk”) and no CV risk factor (“vlCVrisk”) groups.ResultsOverall, mean (SD) patient age was 51.4 (±12.2) years, and 291 (82.4%) subjects were female. Median follow-up was 41.9 (IQR 18.6, 80) months. Overall, 89 (25.2%) individuals developed at least one new CV RF, of which 65 (18.4%) acquired one and 24 (6.8%) two or more. Incident lipid disorders (42, 11.9%), followed by hypertension (14, 4%), atrial fibrillation (17, 4.8%) and venous thromboembolism (VTE) (16, 4.5%), were common. Incident major adverse cardiac events (MACE) were not reported in the vlCVrisk group, in contrast to atCVrisk (<i>n</i> = 8, 4.2%) or overt CVD (<i>n</i> = 4, 18.2%). Age was a significant predictor of incident CV risk factor (HR 1.04, 95% CI: 1.02–1.07; <i>p</i> < 0.01). In age-adjusted analyses, only baseline body mass index (BMI) (HR 1.11, 95% CI: 1.04–1.18; <i>p</i> < 0.01), but not ever smoking (<i>p</i> = 0.93), male sex (<i>p</i> = 0.26), positive RF (<i>p</i> = 0.24), positive ACPA (<i>p</i> = 0.90), or baseline disease activity (<i>p</i> = 0.19), were independent predictor of incident CV risk factors.ConclusionsPatients with RA initiating biologics should be screened for cardiometabolic risk factors, especially at an older age. The presence of at least one risk factor may be linked to a worse long-term prognosis.
Sistem Informasi Penjualan Obat Pada Apotek Serambi Menggunakan Metode Prototype
Authors: Idris Vadya , Solikin Solikin 
Published: January 2024

Abstrak: Sistem penjualan yang ada di Apotek Serambi masih menggunakan metode manual yaitu dengan melakukan pencatatan penjualan di buku penjualan yang mana hal ini tentu tidak efektif. Data tidak terintegrasi sehingga untuk update data dan stok obat di lakukan secara manual. Terlebih lagi sering terjadinya human error dimana pegawai apotek lupa menuliskan transaksi penjualan terhadap satu atau dua pasien atau bahkan lebih. Penelitian ini merancang sistem informasi penjualan obat di Apotek Serambi berbasis web dengan menggunakan metode prototype. Metode prototype merupakan sebuah metode yang terdiri dari tahap komunikasi, perencanaan, pemodelan, konstruksi dan penyerahan. Metode prototype dipilih sebagai metode untuk merancang sistem informasi penjualan obat di Apotek Serambi karena metode ini lebih mudah dipahami penulis, tahapan perancangannya terstruktur serta banyak referensi yang dapat dijadikan pedoman atau acuan untuk merancang sebuah sistem dengan menggunakan metode prototype. Diharapkan dengan adanya sistem informasi penjualan obat di Apotek Serambi yang terkomputerisasi ini mampu mempermudah pegawai dalam melakukan kegiatan proses bisnis yang ada di Apotek Serambi.

Kata kunci: Apotek, Sistem Informasi, Penjualan, Prototype, Obat

Abstract: The sales system at Serambi Pharmacy still uses the manual method, namely by recording sales in the sales book, which of course is not effective. The data is not integrated so updates and drug stocks are done manually. What's more, human errors often occur where pharmacy employees forget to write down sales transactions for one or two patients or even more. This study designed a web-based drug sales information system at Serambi Pharmacy using the prototype method. The prototype method is a method that consists of the stages of communication, planning, modeling, construction and delivery. The prototype method was chosen as a method for designing drug sales information systems at Serambi Pharmacy because this method is easier for the author to understand, the design stages are structured and there are many references that can be used as guidelines or references for designing a system using the prototype method. It is hoped that the existence of a computerized drug sales information system at the Serambi Pharmacy will be able to make it easier for employees to carry out business process activities at the Serambi Pharmacy.

Keywords: Information System, Sales, Prototype, Medicine, Pharmacy
Sistem inventaris berbasis web di workshop Teknik Elektro
Authors: Amrozi M Ali , Widyassari Adhika Pramita 
Published: January 2024

This inventory information system provides several facilities that can be used by the manager, including: input of item data, delete item search item, and item data inventory report, item inventory system at the Electrical Engineering Workshop - STTR CEPU aims to facilitate the laboratory manager in data collection goods, both complementary goods or consumables, which are web-based, for example inputting new goods or damaged goods, can be done online, and the number of goods will be automatically entered in the database, without us adding up the goods manually, search results for item data more easily fast, accurate, and the results of reports that can be downloaded in PDF type, and can be printed. The purpose of the research is to increase efficiency in managing computerized laboratory inventory so that it can support the performance of lab managers, Archives and Electrical Engineering workshops, Designing this application using language programming PHP, CSS, HTML, Windows 10 64 bit Operating System, Visual Studio Code software version 1.69.1, Xampp Server version 1.7.7, PHP version 7.3.2, Bootstrap version 5.0, Google Chrome, 000webhost. The test results show that 77% of this application can run and make it easier for the Cepu-Sttr Laboratory manager.
Keywords: Inventory System, Laboratory, Cepu Sttr
Jednoręki bandyta [polski oryginał]
Authors: Jankowski Wojciech 
Published: January 2024

Artykuł prezentuje eksperyment myślowy dotyczący nieco dziwnej planety Losoria. Na tej planecie odpowiedzialność za pewne rodzaje przestępstw przypisywana jest w sposób całkowicie losowy. Eksperyment ma na celu wzmocnienie naszych intuicji moralnych wspierających zasadę kontroli w sporze o tzw. traf moralny. Ponadto stymuluje on refleksję nad niemoralnymi przesłankami różnicowania odpowiedzialności karnej ponoszonej za skutki działań znajdujących się poza kontrolą podmiotu. Autor wskazuje, że możliwym rozwiązaniem pewnych aporii wynikających z trafu konsekwencji jest przyjęcie sprawiedliwości naprawczej jako formy racjonalizacji kary.
Sharia Perspective: The Urgency of Islamic Economic, Banking and Finance (IEBF) Reform in realizing the Sustainable Development Goals (SDGs) through Knowledge Integration (IoK) Approach
Authors: Hamid Ahmad Munir 
Published: January 2024

This research explores the pressing need for reform within the realm of Islamic Economic, Banking, and Finance (IEBF) from a Sharia perspective, with a particular focus on its crucial role in advancing the Sustainable Development Goals (SDGs). What sets this study apart is its innovative approach, emphasizing Knowledge Integration (IoK) as a powerful tool for achieving this reform. Through a comprehensive examination of IoK's methodological principles, including permissibility, acceptability, authenticity, and contextual adaptability, this research seeks to uncover novel ways to align IEBF practices with the principles of Sharia and the SDGs. The study emphasizes the importance of policymakers actively supporting both academic and industry efforts to incorporate IoK principles into IEBF practices. By doing so, it aims to validate the effectiveness of these principles in achieving the SDGs and fulfilling the broader maqasid. Moreover, the research highlights the potential for substantial cost savings when extracting valuable insights from the legacy writings of IoK and IEBF to guide contemporary IEBF practices. In summary, this study sheds light on the unique novelty of adopting the Knowledge Integration (IoK) approach to reform IEBF in alignment with Sharia principles and the SDGs. By doing so, it not only strengthens the scientific foundations of IEBF but also paves the way for its broader and more impactful contribution to sustainable development on a global scale.
Keywords: Integration of Knowledge, (IEBF), Sharia, and SDGs.
Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma
Authors: Song Yang , Zhang Hao-Jun , Song Xia , Geng Jie , Li Hong-Yi , Zhang Li-Zhong , Yang Bo , Lu Xue-Chun 
Published: January 2024

BACKGROUND
Multiple myeloma (MM) is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone marrow. The translocation, (t)(4;14), results in high-risk MM with limited treatment alternatives. Thus, there is an urgent need for identification and validation of potential treatments for this MM subtype. Microarray data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic targets.
AIM
To elucidate the molecular basis and search for potential effective drugs of t(4;14) MM subtype by employing a comprehensive approach.
METHODS
The transcriptional signature of t(4;14) MM was sourced from the Gene Expression Omnibus. Two datasets, GSE16558 and GSE116294, which included 17 and 15 t(4;14) MM bone marrow samples, and five and four normal bone marrow samples, respectively. After the differentially expressed genes were identified, the Cytohubba tool was used to screen for hub genes. Then, the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis. Using the STRING database and Cytoscape, protein–protein interaction networks and core targets were identified. Potential small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis, respectively.
RESULTS
In this study, a total of 258 differentially expressed genes with enriched functions in cancer pathways, namely cytokine receptor interactions, nuclear factor (NF)-κB signaling pathway, lipid metabolism, atherosclerosis, and Hippo signaling pathway, were identified. Ten hub genes (cd45, vcam1, ccl3, cd56, app, cd48, btk, ccr2, cybb, and cxcl12 ) were identified. Nine drugs, including ivermectin, deforolimus, and isoliquiritigenin, were predicted by the Connectivity Map database to have potential therapeutic effects on t (4;14) MM. In molecular docking, ivermectin showed strong binding affinity to all 10 identified targets, especially cd45 and cybb . Ivermectin inhibited t(4;14) MM cell growth via the NF-κB pathway and induced MM cell apoptosis in vitro. Furthermore, ivermectin increased reactive oxygen species accumulation and altered the mitochondrial membrane potential in t(4;14) MM cells.
CONCLUSION
Collectively, the findings offer valuable molecular insights for biomarker validation and potential drug development in t(4;14) MM diagnosis and treatment, with ivermectin emerging as a potential therapeutic alternative.
Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma
Authors: Li Yan , Lee William , Zhao Zhen-Gang , Liu Yi , Cui Hao , Wang Hao-Yu 
Published: January 2024

BACKGROUND
Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide. Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival, growth, and evolution. Emerging evidence suggests the importance of fatty acid binding proteins (FABPs) in contribution to cancer progression and metastasis; however, how these FABPs are dysregulated in cancer cells, especially in HCC, and the roles of FABPs in cancer progression have not been well defined.
AIM
To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.
METHODS
We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma (LIHC) as well as patient cohorts with other cancer types in this study. We investigated genetic alterations of FABPs in various cancer types. mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome, enriched cancer hallmarks and oncogenes previously reported for patients with HCC. We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.
RESULTS
We discovered that a gene cluster including five FABP family members (FABP4, FABP5, FABP8, FABP9 and FABP12 ) is frequently co-amplified in cancer. Amplification, in fact, is the most common genetic alteration for FABPs, leading to overexpression of FABPs. FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues. High FABP5 expression correlates well with worse patient outcomes (P < 0.05). FABP5 expression highly correlates with enrichment of G2M checkpoint (r = 0.33, P = 1.1e-10), TP53 signaling pathway (r = 0.22, P = 1.7e-5) and many genes in the gene sets such as CDK1 (r = 0.56, P = 0), CDK4 (r = 0.49, P = 0), and TP53 (r = 0.22, P = 1.6e-5). Furthermore, FABP5 also correlates well with two co-expressed oncogenes PLK1 and BIRC5 in pan cancer especially in LIHC patients (r = 0.58, P = 0; r = 0.58, P = 0; respectively). FABP5high Huh7 cells also expressed higher protein levels of p53, BIRC5, CDK1, CDK2, and CDK4 than FABP5low HepG2 cells. FABP5 inhibition more potently inhibited the tumor cell growth in Huh7 cells than in HepG2 cells.
CONCLUSION
We discovered that FABP5 gene is frequently amplified in cancer, especially in HCC, leading to its significant elevated expression in HCC. Its high expression correlates well with worse patient outcome, enriched cancer hallmarks and oncogenes in HCC. FABP5 inhibition impaired the cell viability of FABP5high Huh7 cells. All these support that FABP5 is a novel therapeutic target for treating FABP5high HCC.
Radiotherapy for hyoid bone metastasis from lung adenocarcinoma: A case report
Authors: Hsu Jonathan , Hribar Kambridge , Poen Joseph 
Published: January 2024

BACKGROUND
Metastasis to the hyoid bone is an exceptionally rare occurrence, with documented cases limited to breast, liver, colon, skin, lung, and prostate cancers. This report highlights an unusual case involving the metastasis of lung adenocarcinoma to the hyoid bone, accompanied by a distinctive headache. Previous documentation involved surgical resection of the hyoid mass. We present a case displaying the benefits of palliative radiotherapy.
CASE SUMMARY
A 72-year-old non-smoking, non-alcoholic woman, initially under investigation for a year-long elevation in absolute lymphocyte count, presented with a month-long history of intermittent throat pain. Despite negative findings in gastroenterological and otolaryngologic examinations, a contrast-enhanced chest computed tomography scan revealed a mediastinal mass and questionable soft tissue thickening in her left anterolateral neck. Subsequent imaging and biopsies confirmed the presence of lung adenocarcinoma metastasis to the hyoid bone. The patient was treated with platinum-based chemo-immunotherapy along with pembrolizumab. Ultimately, the lung cancer was unresponsive. Our patient opted for palliative radiation therapy instead of surgical resection to address her throat pain. As a result, her throat pain was alleviated, and it also incidentally resolved her chronic headaches. This is the second documented case of lung adenocarcinoma metastasizing to the hyoid bone.
CONCLUSION
Palliative radiotherapy may add to the quality of life in symptomatic patients with cancer metastatic to the hyoid bone.
Scinderin promotes glioma cell migration and invasion via remodeling actin cytoskeleton
Authors: Lin Xin , Zhao Zhao , Sun Shu-Peng , Liu Wei 
Published: January 2024

BACKGROUND
Glioma is one of the most common intracranial tumors, characterized by invasive growth and poor prognosis. Actin cytoskeletal rearrangement is an essential event of tumor cell migration. The actin dynamics-related protein scinderin (SCIN) has been reported to be closely related to tumor cell migration and invasion in several cancers.
AIM
To investigate the role and mechanism of SCIN in glioma.
METHODS
The expression and clinical significance of SCIN in glioma were analyzed based on public databases. SCIN expression was examined using real-time quantitative polymerase chain reaction and Western blotting. Gene silencing was performed using short hairpin RNA transfection. Cell viability, migration, and invasion were assessed using cell counting kit 8 assay, wound healing, and Matrigel invasion assays, respectively. F-actin cytoskeleton organization was assessed using F-actin staining.
RESULTS
SCIN expression was significantly elevated in glioma, and high levels of SCIN were associated with advanced tumor grade and wild-type isocitrate dehydrogenase. Furthermore, SCIN-deficient cells exhibited decreased proliferation, migration, and invasion in U87 and U251 cells. Moreover, knockdown of SCIN inhibited the RhoA/focal adhesion kinase (FAK) signaling to promote F-actin depolymerization in U87 and U251 cells.
CONCLUSION
SCIN modulates the actin cytoskeleton via activating RhoA/FAK signaling, thereby promoting the migration and invasion of glioma cells. This study identified the cancer-promoting effect of SCIN and provided a potential therapeutic target for the treatment of glioma.
Analysis of metallurgical products for antimony content
Authors: Aubakirova R. A. , Mukazhanova J. B. , Kabdulkarimova K. K. , Afanasenkova I. V. , Sanyazovа S. K. 
Published: January 2024

Antimony is widely used in modern science and technology. Currently, the most important consumer of high-purity antimony is the semiconductor industry.The article presents the results of the analysis of metallurgical samples for the content of antimony, which belongs to the group of harmful impurities.Traditionally, the decomposition of metallurgical samples is carried out by acid dissolution of the sample, alkali fusion or sintering. The least labor-intensive method is acid dissolution. However, this method has a number of significant disadvantages: incomplete opening, loss of antimony due to the hydrolysis of its salts, and the interfering influence of accompanying elements that also pass into solution during acidic dissolution of the sample. The most reliable results in the photometric determination of antimony content can be obtained by sintering a sample, accompanied by the separation of interfering elements by their precipitation in the form of carbonates and the transfer of antimony into a form that is not subject to hydrolysis (MexSbyOz antimonates). However, the specific conditions for the sintering process of antimony-containing metallurgical samples are not described in the literature.The work proposes a method for the decomposition of metallurgical samples, which consists of sintering the samples under study with Na2CO3 + ZnO. The phase composition of the presented samples has been established. A calibration characteristic for the photometric determination of antimony content in the concentration range from 1•10-3 to 1•10-2 mg/ml at a wavelength of 425 nm was constructed.
Problems of ensuring the safety of automated systems
Authors: Alimzhanova Z. M. , Baiuzakova A. K. 
Published: January 2024

The article discusses the issue of "automated system and its security", which is actively used today in the framework of Information Systems. In what areas are automated systems used, the problem of strength in terms of safety and analysis of the state of protection is solved. Automated systems are of great importance in the modern world, as they greatly simplify and speed up the implementation of various daily tasks, data and process management. The relevance of automated systems depends on such factors as efficiency and productivity, improving data quality, scaling, and developing analytics. However, it is important to understand that with the growth of automation, the risk in the field of data security and privacy will also increase.Automated systems become targets of cyber attacks and can threaten the confidentiality, integrity and availability of data. Thus, the safety of automated systems remains one of the main issues. That is, the lack of appropriate security measures can lead to data loss, privacy violations and financial losses. Therefore, organizations need to actively invest in the protection and control of their nuclear power plants by implementing access control, encryption, incident detection mechanisms, and training employees in safety regulations.