bluuebunny/crossref_metadata_2025_split huggingface dataset:
TINGKAT PEMAHAMAN MALPRAKTIK PADA MAHASISWA FAKULTAS HUKUM UNIVERSITAS LAMBUNG MANGKURAT
Authors: Angi Vinni Fioleta , Nirmalasari Nila , Husairi Ahmad , Aflanie Iwan , Panghiyangani Roselina 
Published: December 2023

Kasus malpraktik kini sudah menjadi salah satu masalah paling utama yang berkaitan dengan hukum kesehatan dan pelayanan kesehatan. Meskipun saat ini undang-undang kesehatan dan praktik kedokteran sudah memperkuat status hukum bagi pasien dan menyetarakan hubungan hukum antara pasien dan dokter namun peningkatan kasus-kasus malpraktik tidak dapat dihindari. Pada tahun 2006 hingga 2012 sudah ada tercatat 183 kasus malpraktik medik yang di lakukan oleh dokter maupun perawat. Saat ini masyarakat sudah semakin sadar bahwa dokter dapat dituntut bila dicurigai melakukan tindakan yang melanggar etika atau hukum yang mana jika tuntutan yang berlebihan dan tidak diiringi dengan pemahaman yang cukup tentang sistem dan kondisi dari pelayanan kesehatan maka akan terus terjadi ketidakpuasan akan pelayanan kesehatan dan mudah memberikan tuduhan malpraktik medik.Metode penelitian yang digunakan adalah penelitian observasional, yaitu dengan mengambil data pada mahasiswa fakultas hukum menggunakan kuisioner untuk mendeskripsikan tingkat pemahaman mahasiswa Fakultas Hukum Universitas Lambung Mangkurat mengenai malpraktik medik dan untuk mengetahui tingkat pemahaman malpraktik medik pada mahasiswa Fakultas Hukum. Hasil Penelitian menunjukkan bahwa tingkat pemahaman malpraktik medik mahasiswa fakultas hukum Universitas Lambung Mangkurat sebanyak 4 orang (5,5) tinggi, sebanyak 84 orang (92%) sedang dan sebanyak 3 orang(3,3%)rendah.
Risk Factors Analysis in Recurrent Stroke Events: Literature Review
Authors: Sayeeda Adinda , Agianto Agianto , Agustina Rismia , Rizany Ichsan 
Published: December 2023

After the first stroke, according to epidemiological data, there is a 30% risk of recurrent stroke. That events are the population who had suffered stroke and the recurrence rate is 9 times compared to the normal population. Results of research from the Stroke Association stated that the possibility of recurrence stroke was 3.1% in 30 days, 11.1% within one year, 26.4% within five years, and 39.2% within 10 years. This literature review is intended to analyze the risk factors of recurrent stroke events. The literature review was carried out by searching for articles in 2011-2021 in Indonesian and English. There were four databases for providing electronic journal articles, namely Garuda, Google Scholar, Science Direct, and PubMed. The quality of the articles carried out using JBI's Critical Appraisal Tools. Narrative synthesized was used to analyze the data of the review. There were 6 articles synthesized in this review. The review result showed that diabetes mellitus, hypertension, cardiovascular disorders, anemia, obesity, lack of physical activity, high serum of LDL/HDL, non-adherence to treatment, lack of confidence in treatment, lack of knowledge about the disease, and gender can encourage the occurrence of recurrent stroke. Many factors cause recurrent stroke events but diabetes mellitus, hypertension and non-adherence to treatment are most widely discussed in the six articles.
ANALISIS MODIFIKASI SHELL-AND-TUBE HEAT EXCHANGER PADA PENGOLAHAN AIR LIMBAH PT. ANDALAN FURNINDO
Authors: Maulana Antan Noraidi , Muttaqin Katiko Imamul , Riyadi Ahmad , Khoiri M. 
Published: December 2023

Heat exchanger pada proses pengolahan air limbah PT. Andalan Furnindo sering bermasalah. Oleh sebab itu, penulis mencoba untuk memodifikasi desain heat exchanger pada bagian tube, baffle, dan estimasi pressure drop agar mendapat performa yang lebih bagus. Proses pengolahan data dimulai dari memodifikasi dimensi diameter shell, diameter tube, panjang shell, panjang tube, jumlah baffles, jumlah tube dan jenis path aliran fluida. Menghubungkan korelasi antara parameter dengan modifikasi dimensi yang telah dilakukan agar hasil akhir berupa nilai koefisien perpindahan panas dan pressure drop sesuai yang diinginkan. Hasil perhitungan perancangan dengan Dsid =1 m; di = 0,02 m; do = 0,025 m; panjang shell dan tube=4,6 m; B=5; Nt=1176 dan path aliran U adalah menghasilkan Uc=683 dan Uf=569 ; =1691,3 Pa; dan =1276,6 Pa. Dengan memodifikasi diameter tube dan shell yang lebih besar dari setelan pabriknya dapat memudahkan proses perawatan unit dalam hal membersihkan kotoran dalam tube maupun dalam shell. Sehingga performanya stabil, umur pemakaian unit lebih lama, dan waktu perawatan selanjutnya terjadwal dengan baik. Heat exchanger in the waste water treatment process of PT. Andalan Furnindo is frequently in trouble. Therefore, the authors try to modify the heat exchanger design on the tube, baffle, and estimated pressure drop in order to get better performance. The data processing starts from modifying the dimensions of shell diameter, tube diameter, shell length, tube length, number of baffles, number of tubes and type of fluid flow path. Linking the correlation between parameters with dimensional modifications that have been done so that the final result is the value of the heat transfer coefficient and pressure drop as desired. The results of design calculations with Dsid =1 m; di = 0,02 m; do = 0,025 m; length of shell and tube = 4.6 m; B=5; Nt=1176 and the flow path U is to produce Uc=683 dan Uf=569 ; =1691,3 Pa; dan =1276,6 Pa. By modifying the tube and shell diameter which is larger than the factory setting, it can facilitate the unit maintenance process in terms of cleaning dirt in the tube and in the shell. So that the performance is stable, the service life of the unit is longer, and the next maintenance time is properly scheduled.
Preexposure Prophylaxis Uptake Among Spanish-Speaking Transgender Women: A Randomized Controlled Trial in North and South Carolina, 2019–2022
Authors: Rhodes Scott D. , Alonzo Jorge , Mann-Jackson Lilli , Aviles Lucero Refugio , Tanner Amanda E. , Galindo Carla A. , Bessler Patricia A. , Courtenay-Quirk Cari , Garcia Manuel , Sucaldito Ana D. , Smart Benjamin D. , Goldenberg Tamar , Reboussin Beth A. 
Published: December 2023

Objectives. To evaluate Chicas Creando Acceso a la Salud (Girls Creating Access to Health; ChiCAS), a Spanish-language, small-group intervention designed to increase preexposure prophylaxis (PrEP) use, consistent condom use, and medically supervised gender-affirming hormone therapy use among Spanish-speaking transgender Latinas who have sex with men. Methods. Participants were 144 HIV-negative Spanish-speaking transgender Latinas, aged 18 to 59 years, living in North and South Carolina. From July 2019 to July 2021, we screened, recruited, and randomized them to the 2-session ChiCAS intervention or the delayed-intervention waitlist control. Participants completed assessments at baseline and 6-month follow-up. Follow-up retention was 94.4%. Results. At follow-up, relative to control participants, ChiCAS participants reported increased PrEP use (adjusted odds ratio [AOR] = 4.64; 95% confidence interval [CI] = 1.57, 13.7; P < .006). However, ChiCAS participants did not report increased use of condoms or medically supervised gender-affirming hormone therapy. ChiCAS participants reported increases in knowledge of HIV (P < .001), sexually transmitted infections (P < .001), and gender-affirming hormone therapy (P = .01); PrEP awareness (P < .001), knowledge (P < .001), and readiness (P < .001); condom use skills (P < .001); and community attachment (P < .001). Conclusions. The ChiCAS intervention was efficacious in increasing PrEP use among Spanish-speaking, transgender Latinas in this trial. (Am J Public Health. 2024;114(1):68–78. https://doi.org/10.2105/AJPH.2023.307444 )
Health Insurance Coverage and Access to Care by Sexual Orientation During the COVID-19 Pandemic: United States, January 2021–February 2022
Authors: Nguyen Kevin H. , Levengood Timothy W. , Allen Heidi L. , Gonzales Gilbert 
Published: December 2023

Objectives. To compare health insurance coverage and access to care by sex and sexual minority status during the COVID-19 pandemic and assess whether lack of insurance hindered access to care by sexual minority status. Methods. Using Behavioral Risk Factor Surveillance System data (January 2021–February 2022), we examined differences by sex and sexual orientation among 158 722 adults aged 18 to 64 years living in 34 states. Outcomes were health insurance coverage type and 3 access to care measures. Results. Sexual minority women were significantly more likely to be uninsured than were heterosexual women, and lack of insurance widened the magnitude of disparity by sexual minority status in all measures of access. Compared with heterosexual men with health insurance, sexual minority men with health insurance were significantly more likely to report being unable to afford necessary care. Conclusions. During the pandemic, 1 in 8 sexual minority adults living in 34 study states were uninsured. Among sexual minority women, lack of insurance widened inequities in access to care. There were inequities among sexual minority men with health insurance. Public Health Implications. Sexual minority adults may be disproportionately affected by the unwinding of the COVID-19 public health emergency and may require tailored efforts to mitigate insurance coverage loss. (Am J Public Health. 2024;114(1):118–128. https://doi.org/10.2105/AJPH.2023.307446 )
Retention of Community Health Workers in the Public Health Workforce: Public Health Workforce Interests and Needs Survey, 2017 and 2021
Authors: Kirkland Chelsey , Dill Janette S. , Karnik Harshada 
Published: December 2023

Objectives. To investigate the organizational factors contributing to the intent of community health workers (CHWs) to quit their jobs in local and state health departments in the United States. Methods. We used the 2017 (n = 844) and 2021 (n = 1014) Public Health Workforce Interests and Needs Survey data sets to predict CHWs’ intent to leave with Stata 17 balanced repeated replication survey estimations. Results. CHWs dissatisfied with organizational support, pay, or job security had high probabilities of reporting an intent to leave (50%, P < .01; 39%, P < .01; and 42%, P < .01, respectively) relative to satisfied or neutral workers (24%, P < .01; 21%, P < .01; and 26%, P < .01, respectively). Conclusions. Improving organizational support, pay satisfaction, and job security satisfaction in public health agencies can significantly improve CHW retention, potentially lowering overall organizational costs, enhancing organizational morale, and promoting community health. Public Health Implications. Our findings shed light on actionable ways to improve CHW retention, including assessing training needs; prioritizing diversity, equity, and inclusion; and improving communication between management and workers. (Am J Public Health. 2024;114(1):44–47. https://doi.org/10.2105/AJPH.2023.307462 )
Evolutionary paths that link orthogonal pairs of binding proteins
Authors: Avizemer Ziv , Martí‐Gómez Carlos , Hoch Shlomo Yakir , McCandlish David M. , Fleishman Sarel J. 
Published: December 2023

Abstract
Some protein binding pairs exhibit extreme specificities that functionally insulate them from homologs. Such pairs evolve mostly by accumulating single-point mutations, and mutants are selected if their affinity exceeds the threshold required for function1–4. Thus, homologous and high-specificity binding pairs bring to light an evolutionary conundrum: how does a new specificity evolve while maintaining the required affinity in each intermediate5,6? Until now, a fully functional single-mutation path that connects two orthogonal pairs has only been described where the pairs were mutationally close, thus enabling experimental enumeration of all intermediates2. We present an atomistic and graph-theoretical framework for discovering low molecular strain single-mutation paths that connect two extant pairs, enabling enumeration beyond experimental capability. We apply it to two orthogonal bacterial colicin endonuclease-immunity pairs separated by 17 interface mutations7. We were not able to find a strain-free and functional path in the sequence space defined by the two extant pairs. But including mutations that bridge amino acids that cannot be exchanged through single-nucleotide mutations led us to a strain-free 19-mutation trajectory that is completely viable in vivo. Our experiments show that the specificity switch is remarkably abrupt, resulting from only one radical mutation on each partner. Furthermore, each of the critical specificity-switch mutations increases fitness, demonstrating that functional divergence could be driven by positive Darwinian selection. These results reveal how even radical functional changes in an epistatic fitness landscape may evolve.
Building footprint data for countries in Africa: to what extent are existing data products comparable?
Authors: Chamberlain Heather R , Darin Edith , Adewole Ademola , Jochem Warren Christopher , Lazar Attila N , Tatem Andrew J 
Published: December 2023

Abstract

Growth and developments in computing power, machine-learning algorithms and satellite imagery spatiotemporal resolution have led to rapid developments in automated feature-extraction. These methods have been applied to create geospatial datasets of features such as roads, trees and building footprints, at a range of spatial scales, with national and multi-country datasets now available as open data from multiple sources. Building footprint data is particularly useful in a range of applications including mapping population distributions, planning resource distribution campaigns and in humanitarian response. In settings with well-developed geospatial data systems, such datasets may complement existing authoritative sources, but in data-scarce settings, they may be the only source of data. However, knowledge on the degree to which building footprint data products are comparable and can be used interchangeably, and the impact of selecting a particular dataset on subsequent analyses remains limited. For all countries in Africa, we review the available multi-country building footprint data products and analyse their similarities and differences in terms of building area and count metrics. We explore the variation between building footprint data products across a range of spatial scales, including sub-national administrative units and different settlement types. Our results show that the available building footprint data products are not interchangeable. There are clear differences in counts and total area of building footprints between the assessed data products, as well as considerable spatial heterogeneity in building footprint coverage and completeness.
The cryo-harness technology for the Athena X-IFU detection chain
Authors: Geoffray H. , Adams J. , Fossecave H. , Cucchetti E. , Bellouard E. , Peille P. , Daniel C. , Maisonnave O. , Guilhem E. , Jolly A. , Maussang I. , Jackon B. , Bandler S. , Doriese B. , Durkin M. , Kuur J. , Leeuwen B.-J. , Kiviranta M. , Prêle D. , Ravera L. , Parot Y. 
Published: December 2023

Abstract

CNES (French Space Agency) is in charge of the development of the X-ray Integral Field Unit (X-IFU) instrument for Athena, the high resolution X-ray spectrometer of the ESA Athena X-ray Observatory. X-IFU will deliver spectra from 0.2 to 12 keV with a spectral resolution in the range of 2.5 eV up to 7 keV on a 5" pixels, with a field of view > 4' equivalent diameter. The main sensor array detection chain is a key part of the instrument, being by far the main contributor to its performance. It involves major partner: NASA GFSC, SRON, VTT, APC, and IRAP. The cryo-harness interconnecting the Focal Plane Assembly (FPA) cold interface to the Warm Front End Electronics (WFEE) is under CNES responsibility. The different technical solutions are the loom technology and the shielded twisted pair technology. Electrical characterizations have been performed on breadboards to assess the crosstalk performances for each solution. The results of these analysis are a driver to perform the trade-off between the cryo-harness technologies.
Production of recombinant chimeric protein of Pseudomonas aeruginosa virulence factors and assessment of its immunogenicity in mice
Authors: Aminnezhad Sargol , Abdi-Alia Ahya , Ghazanfari Tooba , Bandehpour Mojgan , Azarakhsh Yousef 
Published: December 2023

Abstract

Escalating mortality rates attributed to drug-resistant Pseudomonas aeruginosa and the substantial complications arising from its infections present a global health crisis. Consequently, the need for innovative therapeutic approaches, notably immunogenic vaccines, has become imperative. Despite extensive research, it is still uncertain whether Pseudomonas aeruginosa immunization can effectively protect against acute and chronic infections. Additionally, the immune response triggered by this immunization is not strong enough against these bacteria. This study aims to devise a chimeric vaccine encompassing key virulence factors of P. aeruginosa that play roles in distinct infection phases. Moreover, these factors possess the capacity to interact with immune receptors, thereby enhancing innate and acquired immune reactions against this bacterium. In this investigation, an in-depth analysis of the P. aeruginosa profile informs the design of the antigenic chimeric structure named PAV3. This construct incorporates lectin, HIV TAT peptide, the N-terminal fragment of exotoxin A, and the Epi8 outer membrane protein F (OprF). Employing an immunoinformatic approach, B cell epitopes, HTL epitopes, CTL epitopes, and IFN-γ are predicted. The PAV3 construct is then expressed in E. coli strain BL21 and purified using affinity chromatography. Immunogenicity assessment of PAV3 entails measuring total IgG, IgG2a, and IgG1, along with specific cytokines (IFN-γ and IL-4) associated with Th1 and Th2 responses, respectively, in vaccinated BALB/c mice. Vaccination with the chimeric vaccine in BALB/c mice triggers a robust Th1 response characterized by elevated production of IgG2a and IFN-γ. This bodes well for inducing potent humoral and cellular immune responses, affording heightened protection. However, the introduction of alum adjuvant alongside PAV3 redirects the immune response toward Th2, leading to reduced protection against internal P. aeruginosa challenges compared to PAV3 alone. In summation, the designed vaccine elicits innate, humoral, and cellular immune responses, offering a promising strategy to manage host-P. aeruginosa interactions and surmount challenges associated with P. aeruginosa vaccination.
BE-WEL Trial (Breast: Evaluation of Weight and Exercise for Lymphoedema) Testing weight control and exercise programmes for women with breast cancer related lymphoedema: a feasibility trial
Authors: Harvie Michelle , Livingstone Karen , Pegington Mary , Lombardelli Cheryl , McMullan Debbie , Farragher Maggie , Barrett Emma , Adams Judiith , Bundred Nigel 
Published: December 2023

Abstract

Purpose
A combined body weight loss and upper body / arm exercise programme is a potential effective management for Breast cancer related lymphoedema (BCRL), but there is limited data on its efficacy, or the best way it could be delivered.
Methods
Fifty–seven women with overweight/obesity and BCRL were randomised to a supervised (n = 12) or home-based combined weight loss and upper body/arm exercise programme (n = 16), a home-based upper-body arm exercise only programme (n = 17) or standard care (n = 12).
Results
Sixteen percent of women invited joined the study. Reductions in weight occurred in the supervised and home-based weight control and exercise programmes; Mean (95% CI) change compared to standard care -1.68 (-4.36 to -1.00), -2.47(-4.99 to -0.04)Kg. Reductions in perometer assessed BCRL were seen in the supervised and home-based combined weight control and arm exercise groups and the weight stable home-based arm exercise only group: Mean (95% CI) change compared to standard care -96(-185 to -6), -61(-144 to +22), -77 (-159 to + 4)ml. There was no correlation between changes in the perometer and the bio impedance electrical analysis (BEA) measurements R=0.068 (P=0.49).
Conclusion
Supervised and home-based weight control and exercise programmes led to modest changes in weight and reductions in BCRL which were comparable to a weight stable group undertaking arm exercise only. Bioelectrical impedance does not appear to be a good measure of changes in BCRL with weight loss and upper body resistance exercise.
Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang and its Metabolites
Authors: Lee So-Young , Hong Geun-Hye , Park Kun-Young 
Published: December 2023

Abstract

In this study, the anticancer effect of doenjang according to the type of salt was investigated. Three samples were prepared: doenjang made with purified salt (PSD), doenjang made with generally manufactured solar salt (GSD), and doenjang made with washed and dehydrated solar salt (WDSD). In mice in which colon cancer was induced with azoxymethane (AOM)/dextran sodium sulfate (DSS), doenjang made with solar salt, especially doenjang made with washed and dehydrated solar salt, was found to have a much higher colon cancer inhibition effect. WDSD significantly promoted the mRNA expression of apoptosis-related factors such as Bcl-2–associated X protein (Bax) and caspase 9 and the cell cycle arrest-related factors p53 and p21, and conversely significantly reduced the mRNA expression of apoptosis inhibitors such as B-cell lymphoma-2 (Bcl-2) (p < 0.05). Additionally, metabolites were investigated to determine which substances in WDSD exhibit this anticancer effect. As a result, the contents of isoflavone and soyasaponin B in the form of aglycons such as genistein, daidzein, and glycitein, which are known to have anticancer and anti-inflammatory properties, were found to be significantly high. Therefore, the results confirmed that doenjang prepared with washed and dehydrated solar salt has superior anticancer potential against colon cancer, and that various active ingredients contribute to the improvement of this functionality.
Artificial intelligence-based morphometric signature to identify ductal carcinoma in situ with low risk of progression to invasive breast cancer
Authors: Sobral-Leite Marcelo , Castillo Simon , Vonk Shiva , Melillo Xenia , Lam Noomie , de Bruijn Brandi , Hagos Yeman , Sanders Joyce , Almekinders Mathilde , Visser Lindy , Groen Emma , Kristel Petra , Ercan Caner , Azarang Leyla , Yuan Yinyin , Consortium Grand Challenge PRECISION , Menezes Renee , Lips Esther , Wesseling Jelle 
Published: December 2023

Abstract

Ductal carcinoma in situ (DCIS) may progress to ipsilateral invasive breast cancer (iIBC), but often never will. Because DCIS is treated as early breast cancer, many women with harmless DCIS face overtreatment. To identify these women that may forego treatment, we hypothesized that DCIS morphometric features relate to the risk of subsequent iIBC. We developed an artificial intelligence-based DCIS morphometric analysis pipeline (AIDmap) to detect DCIS as a pathologist and measure morphological structures in hematoxylin-eosin-stained (H&E) tissue sections. These were from a case-control study of patients diagnosed with primary DCIS, treated by breast-conserving surgery without radiotherapy. We analyzed 689 WSIs of DCIS of which 226 were diagnosed with subsequent iIBC (cases) and 463 were not (controls). The distribution of 15 duct morphological measurements in each H&E was summarized in 55 morphometric variables. A ridge regression classifier with cross validation predicted 5-years-free of iIBC with an area-under the curve of 0.65 (95% CI 0.55–0.76). A morphometric signature based on the 30 variables most associated with outcome, identified lesions containing small-sized ducts, low number of cells and low DCIS/stroma area ratio. This signature was associated with lower iIBC risk in a multivariate regression model including grade, ER, HER2 and COX-2 expression (HR = 0.56; 95% CI 0.28–0.78). AIDmap has potential to identify harmless DCIS that may not need treatment.