bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of temporomandibular disorders in juvenile idiopathic arthritis evaluated with diagnostic criteria for temporomandibular disorders: A systematic review with meta‐analysis
Authors: Ronsivalle Vincenzo , Marrapodi Maria Maddalena , Tirupathi Sunnypriyatham , Afnan Lamea , Cicciù Marco , Minervini Giuseppe 
Published: November 2023

AbstractBackgroundJuvenile idiopathic arthritis (JIA) is a very common systemic inflammatory rheumatic disorder affecting the musculoskeletal system in children below 16 years of age. Joint inflammation and tissue destruction is the prime characteristic of the disease. Along with the systemic involvement in the long joints, several studies are mentioning the increased association of temporomandibular disorders (TMDs) in JIA. This current systematic review intends to find the prevalence rate of TMD in JIA‐affected individuals as compared to healthy controls.MethodsWe have searched in PubMed, Scopus and Ovid SP for articles published between the timeframe 1 January 1990 and 1 June 2023. All the searched articles were subjected to the Population, Exposure, Comparison, and Outcome model (PECO) based on which inclusion or exclusion is carried out. Participants (P) are children below 18 years of age, Exposure (E) is children or adolescents with a diagnosis of JIA, Comparator is age and gender‐matched healthy controls who has no JIA or any systemic disorder, Outcome (O) is the prevalence of TMD. Only the studies that evaluated TMD using diagnostic criteria for evaluation of TMD (DC/TMD) were included in the analysis. We have set the exclusion to the following reasons‐ diagnostic sensitivity studies, case reports, and systematic reviews. The software Review Manager Version 5.4 (Cochrane Collaboration) was used to perform the pooled analysis. We measured the risk ratio (RR) between the two groups (JIA and no JIA) for the outcome TMD.ResultsThe pooled total included subjects were 366 in this review with an established diagnosis of JIA as evaluated by DC/TMD. The overall effect of the pooled data suggests that there is a significant difference in the TMD prevalence in the JIA group when compared to the control, results suggest that TMD is more prevalent in the JIA group RR 3.86; 95% CI [2.59, 5.76].ConclusionOverall, based on the data we can suggest a positive relationship between JIA and TMD, hence presence of JIA can be a risk factor for the development of TMD. The sensitivity of DC/TMD is low when compared to magnetic resonance imaging.
High and low levels of adolescent peer status are associated longitudinally with socioevaluative concern
Authors: Field Nathan H. , Nick Elizabeth A. , Massing‐Schaffer Maya , Fox Kara A. , Nesi Jacqueline , Prinstein Mitchell J. 
Published: November 2023

AbstractThis study examined linear and curvilinear longitudinal associations between peer status (i.e., likeability and popularity) and socioevaluative concern, a socio‐cognitive feature characterized by attunement to judgment from peers. A sample of 716 adolescents (Mage = 16.01, SD = 1.25; 54% female; 46.5% White; 69.5% reduced‐price lunch) was assessed twice annually. Likeability and popularity were assessed with peer nominations at Time 1. Measures of general (rejection sensitivity, peer importance) and online (digital status seeking, online status importance) socioevaluative concern were obtained at Times 1 and 2. High and low levels of likeability were longitudinally associated with increased peer importance, while high and low levels of popularity were associated with increased digital status seeking, and decreased online status importance for girls.
Effects of a high‐fat and high‐carbohydrate diet on appetite regulation and central AMPK in the hypothalamus of blunt snout bream (Megalobrama amblycephala)
Authors: Abasubong Kenneth Prudence , Jiang Guang‐Zhen , Guo Hui‐Xing , Wang Xi , Huang Yang‐yang , Li Xiang‐Fei , Yan‐zou Dong , Liu Wen‐bin , Desouky Hesham Eed 
Published: November 2023

AbstractAdenosine monophosphate‐activated protein kinase (AMPK) is a sensor of cellular energy changes and controls food intake. This study investigates the effect of a high‐calorie diet (high fat diet [HFD], high carbohydrate diet [HCD] and high energy diet [HED]) on appetite and central AMPK in blunt snout bream. In the present study, fish (average initial weight 45.84 ± 0.07 g) were fed the control, HFD, HCD and HED in four replicates for 12 weeks. At the end of the feeding trial, the result showed that body mass index, specific growth rate, feed efficiency ratio and feed intake were not affected (p > 0.05) by dietary treatment. However, fish fed the HFD obtained a significantly higher (p < 0.05) lipid productive value, lipid gain and lipid intake than those fed the control diet, but no significant difference was attributed to others. Also, a significantly higher (p < 0.05) energy intake content was found in fish‐fed HFD, HCD and HED than those given the control diet. Long‐term HFD and HCD feeding significantly increased (p < 0.05) plasma glucose, glycated serum protein, advanced glycation end product, insulin and leptin content levels than the control group. Moreover, a significantly lower (p < 0.05) complex 1, 2 and 3 content was found in fish‐fed HFD and HCD than in the control, but no differences (p > 0.05) were attributed to those in HED. Fish‐fed HED significantly upregulated (p < 0.05) hypothalamic ampα 1 and ampα 2 expression, whereas the opposite trend was observed in the hypothalamic mammalian target of rapamycin than those in HFD and HCD compared to the control. However, hypothalamic neuropeptide y, peroxisome proliferator‐activated receptor α (pparα), acetyl‐coa oxidase and carnitine palmitoyltransferase 1 were significantly upregulated (p < 0.05) in the HCD group, while the opposite was seen in cholecystokinin expression compared to those in the control group. Our findings indicated that the central AMPK signal pathway and appetite were modulated according to the diet's energy level to regulate nutritional status and maintain energy homoeostasis in fish.
Fossil endocarps of Menispermaceae from the late Paleocene of Paris Basin, France
Authors: Kara Eliise , Bardin Jérémie , De Franceschi Dario , Del Rio Cédric 
Published: November 2023

AbstractMenispermaceae are an angiosperm family of mostly climbing plants distributed throughout tropical regions. The fruits in this family have a strong sclerified endocarp and can be used for reliable species‐level identifications, even in a fossilized form. New Paleocene‐age menispermaceous endocarps have recently been discovered in South America and Asia, while in Europe, they are mostly found in the Eocene. This paper focuses on the study of fossil endocarps belonging to Menispermaceae, found in the Petit‐Pâtis locality, which is one of the few Paleocene localities in Europe. The locality is dated to the late Paleocene (57–56 Ma) and the fossils represent flora and fauna in the Paris Basin before the onset of the Paleocene–Eocene Thermal Maximum. Lignitized fossils were photographed and their morphology was analyzed using computed tomography, scanning electron microscope, and geometric morphometric analysis. The analysis of 36 fossils belonging to Menispermaceae revealed that three genera (Stephania, Palaeosinomenium, Tinospora) were present in the late Paleocene of Paris Basin. Differences in internal morphology and a more inflated endocarp base led to a description of a new fossil species—Palaeosinomenium oisensis sp. nov. The occurrence of these genera in the Paleocene of France is consistent with the suggestion that megathermal flora was present in the Paris Basin before the Paleocene–Eocene Thermal Maximum. These three genera are currently the oldest occurrences in Europe, highlighting the connection between paleofloras of the Americas, Europe, and Asia in the Paleocene.
Isolated rapid eye movement sleep behaviour disorder (iRBD) in the Island Study Linking Ageing and Neurodegenerative Disease (ISLAND) Sleep Study: protocol and baseline characteristics
Authors: Bramich Samantha , Noyce Alastair J. , King Anna E. , Naismith Sharon L. , Kuruvilla Maneesh Varghese , Lewis Simon J. G. , Roccati Eddy , Bindoff Aidan D. , Barnham Kevin J. , Beauchamp Leah C. , Vickers James C. , Pérez‐Carbonell Laura , Alty Jane 
Published: November 2023

SummaryIsolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is a sleep disorder that is characterised by dream enactment episodes during REM sleep. It is the strongest known predictor of α‐synuclein‐related neurodegenerative disease (αNDD), such that >80% of people with iRBD will eventually develop Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy in later life. More research is needed to understand the trajectory of phenoconversion to each αNDD. Only five ‘gold standard’ prevalence studies of iRBD in older adults have been undertaken previously, with estimates ranging from 0.74% to 2.01%. The diagnostic recommendations for video‐polysomnography (vPSG) to confirm iRBD makes prevalence studies challenging, as vPSG is often unavailable to large cohorts. In Australia, there have been no iRBD prevalence studies, and little is known about the cognitive and motor profiles of Australian people with iRBD. The Island Study Linking Ageing and Neurodegenerative Disease (ISLAND) Sleep Study will investigate the prevalence of iRBD in Tasmania, an island state of Australia, using validated questionnaires and home‐based vPSG. It will also explore several cognitive, motor, olfactory, autonomic, visual, tactile, and sleep profiles in people with iRBD to better understand which characteristics influence the progression of iRBD to αNDD. This paper details the ISLAND Sleep Study protocol and presents preliminary baseline results.
Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression
Authors: Vitali Eleonora , Franceschini Barbara , Milana Flavio , Soldani Cristiana , Polidoro Michela A. , Carriero Roberta , Kunderfranco Paolo , Trivellin Giampaolo , Costa Guido , Milardi Giulia , Di Tommaso Luca , Torzilli Guido , Lleo Ana , Lania Andrea G. , Donadon Matteo 
Published: November 2023

AbstractBackground & AimsIntrahepatic cholangiocarcinoma (iCCA) is a primary liver tumour, characterized by poor prognosis and lack of effective therapy. The cytoskeleton protein Filamin A (FLNA) is involved in cancer progression and metastasis, including primary liver cancer. FLNA is cleaved by calpain, producing a 90 kDa fragment (FLNACT) that can translocate to the nucleus and inhibit gene transcription. We herein aim to define the role of FLNA and its cleavage in iCCA carcinogenesis.Methods & ResultsWe evaluated the expression and localization of FLNA and FLNACT in liver samples from iCCA patients (n = 82) revealing that FLNA expression was independently correlated with disease‐free survival. Primary tumour cells isolated from resected iCCA patients expressed both FLNA and FLNACT, and bulk RNA sequencing revealed a significant enrichment of cell proliferation and cell motility pathways in iCCAs with high FLNA expression. Further, we defined the impact of FLNA and FLNACT on the proliferation and migration of primary iCCA cells (n = 3) and HuCCT1 cell line using silencing and Calpeptin, a calpain inhibitor. We observed that FLNA silencing decreased cell proliferation and migration and Calpeptin was able to reduce FLNACT expression in both the HuCCT1 and iCCA cells (p < .05 vs. control). Moreover, Calpeptin 100 μM decreased HuCCT1 and primary iCCA cell proliferation (p <.00001 vs. control) and migration (p < .05 vs. control).ConclusionsThese findings demonstrate that FLNA is involved in human iCCA progression and calpeptin strongly decreased FLNACT expression, reducing cell proliferation and migration.
Building and maintaining interprofessional collaborative practice in eyecare: Learnings from the Queensland Paediatric Optometry Alignment Program
Authors: Webber Ann L. , Toomey Melinda , Keay Lisa , Dai Shuan , Gole Glen A. , Newcomb Dana , McKinlay Lynne 
Published: November 2023

AbstractPurposeThe Queensland Children's Hospital Paediatric Optometry Alignment Program commenced with a pilot phase to assess its feasibility, effectiveness and acceptability. This study identified the barriers that hinder effective interprofessional collaboration and the facilitators that contribute to its success, and assessed changes in optometrists' satisfaction since the pilot phase of the collaborative care programme.MethodsQualitative deductive and inductive content analysis was applied to open‐ended free‐text survey responses collected in 2018 from the optometrists involved in the Program's pilot phase. The responses were coded using the Theoretical Domains Framework (TDF) to categorise barriers and facilitators into key themes. Key behavioural determinants were mapped to the COM‐B (Capability, Opportunity, Motivation‐Behaviour) elements of the Behaviour Change Wheel model to identify intervention strategies. Intervention recommendations were derived from behaviour change mapping and compared with programme quality improvement initiatives. A cross‐sectional explanatory survey informed by the TDF was conducted within the current 2023 cohort, and a longitudinal comparative analysis was carried out using data from the 2018 survey.ResultsAmong the 97 surveys distributed in 2018, 44 respondents participated; from this group, 38 individuals contributed a total of 200 free‐text responses. Facilitators (240 comments) outnumbered barriers (65 comments). Key facilitators were accessible and timely care, professional development, confidence and positive outcome beliefs. Barriers included communication, information handover, credibility, relationships and skill gaps. Optometrists actively engaged in the programme in 2023 reported heightened satisfaction with their involvement, increased confidence and greater engagement in paediatric eyecare delivery. However, challenges in clinical information transfer persist.ConclusionThe interprofessional collaborative model of paediatric eyecare has contributed efficiencies within the health system by building paediatric care capacity in the community, fostering professional credibility and promoting interdisciplinary trust. Insights gained should prove valuable for other paediatric eyecare services exploring hospital‐to‐community care models.
Bipolar radiofrequency ablation between middle cardiac vein and left ventricular endocardium for intramural ventricular tachycardia originating from the left ventricular inferobasal septum
Authors: Baskovski Emir , Akyurek Omer , Altin Timucin 
Published: November 2023

AbstractVentricular tachycardia ablation in the post‐surgical patients is complicated by difficult epicardial access. Endocardial‐only ablation may lead to failure which can be prevented by mapping and ablating inside the coronary venous system. Radiofrequency ablation inside the coronary venous system is dependent on anatomical and biophysical factors. Herein we report a ventricular tachycardia case necessitating bipolar ablation between the middle cardiac vein and the left ventricular endocardium.
Revisiting the forgotten “full‐right full‐left” liver division: Simplified technique and new strategical considerations for clinical implementation in Italy
Authors: de Ville de Goyet Jean , di Francesco Fabrizio , Cintorino Davide , Bici Kejd , Dona Diletta , Bonsignore Pasquale , Gruttadauria Salvatore 
Published: November 2023

AbstractBackgroundFull‐right/full‐left liver splitting was introduced early in the 90s as part of the great wave of technical innovations that characterized that decade. One approach was to divide the liver on the right of the Cantlie's line and leave the middle hepatic vein with the left graft, with both grafts allocated to adults. Both grafts had some functional disadvantages and exposed the adult recipients to some early hepatic dysfunction, and the results were not great. An alternative approach consisted of an ex situ division of the liver, exactly along Cantlie's line, thus sharing the middle hepatic vein between the two grafts. None of these two techniques were really adopted, and there has been nearly no transplantation of this type in the last decade worldwide.Method and resultsThe authors propose a variation of the latter technique that was used recently with success: The division of the liver is made simpler; the two grafts are prepared ex situ and need a simple vascular reconstruction (one venous patch on each graft); and the grafts can be implanted using very standard techniques.ConclusionBecause candidates for liver transplantation weighing 25–60 kg (old children, teenagers, and some small adults) are often at some disadvantage in getting size‐matched livers (this range of weight is less represented in the donor population), implementing the latter technique would help provide adequate grafts for them. In Italy, where many livers offered for splitting are not used, there would be ample room for implementing this option within the actual donor pool and allocation system.
Effects of vector‐borne plant pathogen on the interactions between Diaphorina citri and its natural enemy, Harmonia axyridis
Authors: Shrestha Binita , Ibanez Freddy , Stelinski Lukasz L. 
Published: November 2023

AbstractThe Asian citrus psyllid, Diaphorina citri, is a vector of the bacterial pathogen, Candidatus Liberibacter asiaticus (CLas) that is believed to cause huanglongbing (HLB), also known as citrus greening disease. This phytopathogen can manipulate its vectors directly by modifying behaviour and altering fitness and indirectly by reducing host plant quality, which may affect the predation efficiency of natural enemies. Little is known about how this phytopathogen may affect third tropic level predators. The purpose of this investigation was to determine if the CLas pathogen modifies interactions between D. citri and its predators. We tested whether CLas infection of psyllids indirectly affects fitness of a key predator, the lady beetle Harmonia axyridis. We provided ladybeetles with 10 infected or uninfected adult psyllids in choice bioassays and measured the consumption rate over 24 h. Similarly, 15 infected or uninfected adult psyllids were provided to ladybeetles in no‐choice bioassays and feeding rates and net weight gain of male and female beetles were measured over 5 consecutive days. Fecundity and fertility of lady beetles feeding on CLas‐infected D. citri was reduced compared with those feeding on uninfected D. citri, and oocyte development appeared diminished in those beetles feeding on infected compared with uninfected psyllids. However, in choice assays, beetles did not distinguish between CLas‐infected and uninfected psyllids. We postulate that CLas may reduce the nutritional quality of psyllids diminishing fecundity and fertility of their predatory beetles. Our results lead us to speculate that under conditions of near 100% HLB infection, as occurs endemically in Florida, effectiveness of biological control for D. citri may benefit from provisioning ladybeetle predators with alternative hosts of higher nutritional quality or augmentative releases of laboratory‐reared predators.
A Cerasus humilis transcription factor, ChDREB2C, enhances salt tolerance in transgenic Arabidopsis
Authors: Wang D. , Ji X. L. , Li Z. , Zhang M. Y. , Liu M. P. , Song X. S. 
Published: November 2023

Abstract

DREB transcription factors play important roles in plant responses to various abiotic and biotic stresses.

We conducted bioinformatics analysis of ChDREB2C, explored subcellular localization, transcription activation activity, and heterologous expression in Arabidopsis, and measured expression of related physiological indicators and genes under salt stress.

A transcription factor of the DREB family was cloned and named ChDREB2C. ChDREB2C protein was localized in the nucleus, and its C‐terminal domain exhibited transcriptional activation activity. ChDREB2C formed a homologous dimer in yeast. Arabidopsis plants overexpressing ChDREB2C were more tolerant to salt stress than WT plants, through increased scavenging capacity of ROS and accumulation of proline. Overexpression of ChDREB2C resulted in increased expression of AtSOS1, AtNHX1, AtRD29A, AtRD29B, AtKIN1, AtABA4, and AtABF2 genes. The interaction between ChABF2 (ABA response element binding factor 2) and ChDREB2C was verified using yeast two‐hybrid and firefly luciferase assays.

The results suggest that ChDREB2C could have a positive role in mediating the abiotic response.
Optimizing selection strategy for enhancing reproduction efficiency in Indian crossbred goats using milk productivity as a selection criterion
Authors: Upadhyay Amritanshu , Alex Rani , Sahoo Shweta , Khan Kashif Dawood , Das Pradyut , Dige Mahesh Shivanand , Vohra Vikas , Gowane Gopal Ramdasji 
Published: November 2023

AbstractThe present study was aimed at optimizing the selection strategy for enhancing reproductive efficiency and milk productivity of Alpine × Beetal crossbred goats. The data set included 2949 milk trait records across parities and 1389 milk records from first parity and corresponding reproductive traits. The traits included for analysis were 150‐day milk yield (150DMY), days in milk (DIM), peak yield (PY) and total milk yield (TMY). The litter size (LS) and litter weight (LW) were used for specifically formulating selection plan using indirect selection. The least squares mean for lactation traits during the first parity were 150DMY: 195.32 ± 2.09 kg, DIM: 236.42 ± 3.04 days, PY: 1.82 ± 0.02 kg, TMY: 269.62 ± 4.52 kg. Notably, Alpine × Beetal goats demonstrated genetic superiority pan India for milk productivity as compared to other native goat breeds. The least squares mean for 150DMY across all parities was 236 ± 3.13 kg. An animal model employing average information restricted maximum likelihood was used for (co)variance component estimation to get the genetic parameters. The analysis revealed total heritability estimates for 150DMY, DIM, PY and TMY as 0.18 ± 0.06, 0.04 ± 0.04, 0.12 ± 0.06 and 0.08 ± 0.05, respectively. Repeatability estimates for 150DMY, DIM, and TMY were 0.28 ± 0.04, 0.21 ± 0.03 and 0.37 ± 0.03, respectively. Bivariate analysis of 150DMY with reproductive traits revealed heritability for LS and LW as 0.05 ± 0.01 and 0.10 ± 0.01, respectively using Gibbs sampling. Strong and positive genetic correlations of 150DMY with other production and reproduction traits was observed, such as DIM (0.72), PY (0.98), TMY (0.88), LS (0.57) and LW (0.33). Moderate heritability and repeatability estimate of 150DMY, along with its positive correlation with production and reproductive traits suggested it as a suitable selection criterion for early selection and overall genetic progress of lactation traits. The genetic trend analysis showed an overall improvement in all these traits, with observed gain of 98.4 g per year for 150DMY, 0.04 days per year for DIM, 0.5 g per year for PY and 220.5 g per year for TMY. We observed that selecting based on 150DMY would lead to a favourable indirect improvement for LW as 79 g and LS 0.04 units per generation. We, therefore, recommend employing 150DMY as the single trait selection criteria to enhance both milk productivity and reproductive potential of Alpine × Beetal goats.