bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yeast competition during alcoholic fermentation of agave. Its comprehension as a way to reach sustainable mezcal production
Authors: Acosta‐García Erick D. , Páez‐Lerma Jesús B. , Moreno‐Jiménez Martha R. , Rojas‐Contreras Juan A. , Soto‐Cruz Nicolás O. 
Published: October 2023

SummaryThe mezcal industry faces challenges such as overexploitation of wild agaves, poor cooking processes, incomplete fermentation, little control of the distillation process, and the generation of agro‐industrial waste. Successful fermentation is essential to reach a sustainable agave exploitation process in this context. This review focuses on the interactions between different yeast species in alcoholic fermentation, particularly agave fermentation, for mezcal production. A significant variation was observed regarding techniques, fermentation conditions, and yeasts used. These variations influence the chemical composition of alcoholic beverages, especially mezcal. The influence of various factors, such as the processing method, geographic origin, agave species, used, and microbial populations, is also discussed. An attractive alternative is to design starter cultures with carefully selected yeasts based on a detailed study of their interactions. It would allow reaching an acceptable use of the agave sugars obtaining mezcals with attractive organoleptic characteristics, produced in less time and at a lower cost.
Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes
Authors: Everett Alysha B. , Garvey W. Timothy , Fernandez Jose R. , Habegger Kirk , Harper Lorie M. , Battarbee Ashley N. , Martin Samantha L. , Moore Bethany A. , Fouts Amelia E. , Bahorski Jessica , Chandler‐Laney Paula C. 
Published: October 2023

SummaryBackgroundLeptin resistance occurs with obesity, but it is unknown if individuals at risk for obesity develop leptin resistance prior to obesity.ObjectiveInvestigate whether leptin resistance is independent of weight status in children at risk for obesity due to intrauterine exposure to maternal obesity or gestational diabetes mellitus (GDM).MethodsMother–child dyads (N = 179) were grouped by maternal pregnancy weight and GDM status: (1) normal weight, no GDM; (2) overweight/obesity, no GDM; (3) overweight/obesity with GDM. Children (4–10 years) were further stratified by current body mass index (BMI) <85th or ≥85th percentile. Leptin resistance of children and mothers was calculated as fasting leptin/fat mass index. Two‐way ANOVA was used to assess whether leptin concentrations and leptin resistance differed by current weight status or in utero exposure group, after adjusting for race, sex and Tanner stage.ResultsChildren with a BMI ≥85th percentile had more leptin resistance than those with a BMI <85th percentile (p < 0.001), but leptin resistance did not differ by in utero exposure. Similarly, leptin resistance in women was associated with weight status and not prior GDM.ConclusionsResults suggest that leptin concentrations are associated with obesity but not risk for obesity based on in utero exposure to maternal obesity or GDM.
Contribution of general medicine to perioperative and consultative care: an Australian metropolitan teaching hospital experience
Authors: Buxton David , Low Ashlea V. X. , Gibbs Harry H. , Coates Richard , Aung Ar Kar 
Published: October 2023

AbstractLittle is known about the contribution of general medicine to perioperative and consultative care in Australia. A descriptive observational study was undertaken at a quaternary institution to evaluate the characteristics of perioperative and nonoperative consultations undertaken by general medicine. Results demonstrated patterns of engagement within a ‘traditional’ model of perioperative care and highlighted several opportunities for a redesign to a more proactive and collaborative cross‐disciplinary model.
Comparison between two molar incisor hypomineralization detection criteria in epidemiological surveys
Authors: Mendonça Fernanda Lyrio , Regnault Fabiana Giuseppina Di Campli , Grizzo Isabella Claro , Martins Daiana da Silva , Fragelli Camila , Leal Soraya Coelho , Honório Heitor Marques , Rios Daniela 
Published: October 2023

AbstractBackgroundThere is no consensus on which molar incisor hypomineralization (MIH) indices are more suitable for epidemiological surveys.AimTo compare the operational aspects and diagnostic ability of the MIH index (simplified/MIH_s and extended/MIH_e) with the MIH‐Severity Scoring System (MIH‐SSS) in classifying and diagnosing MIH.DesignThis cross‐sectional study assessed the indices in a homogeneous group of 680 6‐ to 10‐year‐old schoolchildren in Bauru, Brazil, who had at least one first permanent molar, ensuring consistent conditions. Followed by toothbrushing, the children seated on school chairs were examined by the two calibrated researchers under artificial lighting, using mouth mirror and WHO probe, and chronometer recording the duration of examinations.ResultsThe prevalence of MIH was 24.7%. The most common characteristic of MIH was demarcated opacity, with a prevalence of 81.7% and 85.45% according to the MIH_s and the MIH‐SSS, respectively. A positive association was observed among the MIH_s, the MIH_e, and the MIH‐SSS (chi‐squared test; p < .01). The MIH‐SSS demonstrated a shorter average application time than both versions of the MIH index (ANOVA/Tukey; p < .05). Additionally, fluorosis was found to be the most prevalent among other developmental defects of enamel, with a prevalence of 38.38%.ConclusionAll systems effectively diagnosed MIH and its characteristics.
RETRACTED: Effect of hydrocolloid dressing on pressure ulcer in patients with non‐invasive positive pressure ventilation: A meta‐analysis
Authors: Luo Yu‐Lan , Luo Shi‐Feng , Luo Lin , Ou Min , Tang Meng‐Lin 
Published: October 2023

AbstractThis study systematically evaluated the effect of hydrocolloid dressings on facial pressure ulcers in patients receiving non‐invasive positive pressure ventilation (NIPPV). The Embase, PubMed, Cochrane Library, CNKI, VIP, Chinese Biomedical Literature Database and Wanfang databases were searched for randomised controlled trials on the use of hydrocolloid dressings in patients receiving NIPPV published from the inception of each database to August 2023. The literature was independently screened, data were extracted by two authors based on the inclusion and exclusion criteria, and the quality of the included literature was assessed. The meta‐analysis was performed using Stata 17.0. Thirteen studies including 1248 patients were included, with 639 patients in the intervention group and 609 patients in the control group. Meta‐analysis showed that the hydrocolloid dressing significantly reduced the incidence of facial pressure ulcers in patients with NIPPV (odds ratio = 0.16, 95% confidence intervals: 0.11–0.24, p < 0.001). Hydrocolloid dressings are effective in reducing the incidence of facial pressure ulcers in patients receiving NIPPV. However, because of the small number of included studies, this conclusion needs to be confirmed with larger samples and high‐quality clinical studies.
Anti‐α6β4 integrin autoantibodies inhibit the binding of laminins to α6β4 integrin in patients with pemphigoid and affect the gastrointestinal tract
Authors: Arase Noriko , Sasaoka Yusuke , Narita Jun , Kiyohara Eiji , Hashimoto Kazuhisa , Shinzaki Shinichiro , Nojima Satoshi , Takagi Junichi , Fujimoto Manabu 
Published: October 2023

AbstractBackgroundAnti‐α6β4 integrin autoantibodies can be observed in some patients with mucous membrane pemphigoid. We have previously identified anti‐α6β4 integrin extracellular domain autoantibodies together with anti‐BP180 NC16A antibodies in a patient with DPP‐4 inhibitor‐induced bullous pemphigoid. However, the significance and impact of anti‐α6β4 integrin antibodies are unknown.ObjectivesTo characterize anti‐α6β4 integrin extracellular domain autoantibodies in pemphigoid patients, to determine whether these antibodies inhibit laminin‐α6β4 integrin binding and to observe their systemic effects.MethodsAnti‐α6β4 integrin autoantibodies were analysed by staining cells expressing the extracellular region of α6β4 integrin with sera from 20 patients with pemphigoid. The anti‐α6β4 integrin autoantibodies were characterized using different transfectants. The binding of laminins to α6β4 integrin was studied using cells expressing the activated conformation of α6β4 integrin and the inhibitory effect of the autoantibodies on the binding of laminins to α6β4 integrin was tested. Trends in antibody titres and clinical symptoms were quantified and analysed.ResultsIgG autoantibodies against the extracellular domain of anti‐α6β4 integrin were found in some patients with pemphigoid. Laminin binding to α6β4 integrin was observed in the active conformation of α6β4 integrin, and serum from a patient with a high titre of anti‐α6β4 integrin antibodies inhibited the binding of both laminin‐511 and laminin‐332 to α6β4 integrin. α6β4 integrin is expressed on the basement membrane of both skin and small intestine, and exfoliation was observed in the patient's epidermis and small intestinal epithelium. A reduction in the titre of the anti‐α6β4 integrin antibody was associated with improvement in both skin and gastrointestinal symptoms.ConclusionsThis study demonstrated the presence of anti‐α6β4 integrin extracellular domain‐specific autoantibodies in some patients with pemphigoid. In addition, these autoantibodies showed inhibitory activity on α6β4 integrin‐laminin binding. Anti‐α6β4 integrin antibodies can affect the gastrointestinal tract as well as the skin and oral mucosa.
Assessing the performance of parametric and non‐parametric tests for trend detection in partial duration time series
Authors: Amorim Renato , Villarini Gabriele 
Published: October 2023

AbstractThe detection of nonstationarities in partial duration time series (PDS) depends on several factors, including the length of the time series, the selected statistical test, and the heaviness of the tail of the distribution. Because of the more limited attention received in the literature when compared to the trend detection on block maxima variables, we perform a Monte Carlo simulation study to evaluate the performance of different approaches: Spearman's rho, Mann–Kendall, ordinary least squares (OLS), Sen's slope estimator (SEN), and the nonstationary generalized Pareto distribution fit to identify the presence of trends in PDS records characterized by different sample sizes (n), shape parameter (ξ) and degrees of nonstationarity. The results point to a power gain for all tests by increasing n and the degree of nonstationarity and by reducing ξ. The use of a nonparametric test is recommended in samples with a high positive skew. Furthermore, the use of sampling rates greater than one to increase the PDS sample size is encouraged, especially when dealing with small records. The use of SEN to estimate the magnitude of a trend is preferable over OLS due to its slightly smaller probability of occurrence of type S error when ξ is positive.
Nurse practitioner led telehealth services: A scoping review
Authors: Charalambous Julia , Hollingdrake Olivia , Currie Jane 
Published: October 2023

AbstractAimTo explore the educational preparation of nurse practitioners to deliver telehealth services and their impact on access to care.DesignScoping review.MethodsA search was undertaken 4 April 2022. Primary studies that focused on nurse practitioners and their patients/clients engaging in telehealth services in any healthcare setting or clinical area within Australia, New Zealand, United States, Canada, United Kingdom, and Ireland, published between 2010 to 2022, were included. Study findings were analysed using the Levesque et al. (2013) access to care framework and the Patterns, Advances, Gaps, Evidence for Practice and Research Recommendations framework (Bradbury‐Jones et al., 2021). The PRISMA‐ScR checklist was used to guide reporting.Data SourcesCINAHL, Medline, Scopus, and Embase databases.ResultsForty‐two studies were included. Studies (n = 28) relating to access to care focused on appropriateness/ability to engage (n = 14), affordability/ability to pay (n = 1), and availability/ability to reach (n = 13). High levels of telehealth satisfaction were reported, including reduced travel time and costs, and appointment flexibility. Telehealth satisfaction was reduced when a perceived need for physical assessment, or privacy concerns were present. Service providers reported decreased emergency presentations, fewer missed appointments and improved consumer engagement. Fourteen studies related to nurse practitioner education, using a range of approaches such as didactic education modules, simulations and clinical experiences, all published within the past 3 years.ConclusionFindings suggest that nurse practitioner‐led telehealth has improved access to care. High levels of satisfaction indicate patients accept nurse practitioner‐led telehealth. Impacts to healthcare service use and patient engagement further support the viability of nurse practitioner‐led telehealth. The recent increase in telehealth education studies reflects the rapid uptake of telehealth care in the mainstream.Implications for the profession and/or patient carePatients perceive telehealth as acceptable and appropriate to meet their healthcare needs and improve access to care. Telehealth is likely to be a mainstay in ongoing healthcare delivery, therefore, nurse practitioners must have educational preparation to provide telehealth.ImpactThis scoping review provides insight into the ways nurse practitioners deliver telehealth services, how they are educated to provide telehealth services, and their impact on access to care. Nurse practitioner‐led telehealth improves access to care across service provision and consumer perspective domains. Nurse practitioner telehealth education is an emerging topic. This research is valuable for nurse practitioners using telehealth, nurse practitioner educators and telehealth policy decision makers.Reporting MethodPreferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR).Patient or Public ContributionNo Patient or Public Contribution.
PCSK9 inhibitor use during pregnancy in a case of familial hypercholesterolemia complicated with coronary artery disease
Authors: Suzuki Takuma , Tsurane Kotoi , Umemoto Tomoyuki , Sasano Tetsuo , Ushiki Eiko , Fudono Ayako , Hirose Asuka , Sekiguchi Masaki , Miyasaka Naoyuki 
Published: October 2023

AbstractLimited data have been reported on the use of proprotein convertase subtilisin/kexin type 9 (PCSK 9) inhibitors during pregnancy in women with familial hypercholesterolemia (FH). Here, we present the first case of initiating evolocumab (PCSK9 inhibitor) in a compound heterozygous FH mother. The patient was a 34‐year‐old primipara with severe dyslipidemia and a history of coronary artery bypass surgery. An elevated low‐density lipoprotein cholesterol (LDL‐C) level of 420 mg/dL was detected in the first trimester and persistently increased throughout pregnancy. Evolocumab was administered at 31 and 35 weeks of gestation, showing a positive effect on stabilizing LDL‐C levels. Planned delivery with labor analgesia was performed at 38 + 4 weeks. Both the mother and infant were discharged without any notable complications. Hence, evolocumab, an IgG2 monochromatic antibody with little placental permeability, may be an alternative medication with limited influence on infants. Further studies are needed to assess the safety of evolocumab administration during pregnancy.
Telomerase reverse transcriptase gene polymorphisms and cervical cancer susceptibility in high‐risk human papillomavirus‐infected women
Authors: Sun Shuang , Wang Yuhong , Liu Ying , Leng Zongxiang , Jiang Yujuan , Liang Yu , Jiang Zhe 
Published: October 2023

AbstractObjectiveTo investigate the relationship between Human telomerase reverse transcriptase (hTERT) gene polymorphisms and the susceptibility and clinicopathological parameters of cervical cancer in women infected with high‐risk human papillomavirus (HR‐HPV).MethodA total of 380 patients with HPV‐infected cervical cancer who were admitted to the Jilin province Maternal and Child Health Care Hospital (Jilin province Obstetrics Quality Control Center) from July 2019 to July 2023 were selected as case group, and 408 women with negative HPV results in the cervical cancer screening results of the physical examination in the same hospital were selected as the control group. Restriction fragment length polymorphisms polymerase chain reaction was used to detect the polymorphisms of hTERT, and its relationship with the susceptibility to high‐risk HPV infection and clinicopathological parameters in patients with cervical cancer was analysed.ResultsIndividuals carrying the GA and AA genotypes of rs2736122 were significantly associated with an increased risk of cervical cancer when compared with the GG genotype and the adjusted ORs were 0.53 (0.37–0.79) for the AA genotype and 0.73 (0.59–0.88) for the A allele genotype. Besides, GG genotype or G allele of rs2853677 presented a significant influence on cervical cancer, with ORs of 0.59 (0.41–0.86) and 10.77 (0.63–0.94), respectively, when compared with the AA genotype. And rs2853677 have statistically significant difference in tumour diameter and degree of differentiation subgroup(p < 0.05).ConclusionThe results of this study indicate that the hTERT gene rs2736122AA and rs2853677 GG genotypes can increase the susceptibility of high‐risk HPV infection in cervical cancer patients. And rs2853677 is related to tumours above 4 cm and highly differentiated tumours. But both have nothing to do with the patient's chemotherapy sensitivity.
A case–control study on the effect of rhythmic masticatory muscle activity (RMMA) clusters on sleep fragmentation and severity of orofacial muscle pain in sleep bruxism
Authors: Martynowicz Helena , Lavigne Gilles , Kato Takafumi , Poreba Rafal , Michalek‐Zrabkowska Monika , Macek Piotr , Gac Pawel , Wojakowska Anna , Surowiak Pawel , Mazur Grzegorz , Wieckiewicz Mieszko 
Published: October 2023

SummaryRhythmic masticatory muscle activity (RMMA) is a periodic muscle activity that characterises sleep bruxism (SB) events. These can occur as a single event, in pairs, or in clusters. Since RMMA episodes often occur in clusters and the relevance of this occurrence is unknown, we conducted a study to investigate the effect of RMMA clusters on sleep fragmentation and the severity of orofacial muscle pain. This study involved a secondary analysis using data from 184 adult subjects with orofacial muscle pain who underwent definitive polysomnography (PSG) for sleep bruxism diagnosis. Self‐reported orofacial muscle pain (OFMP) was assessed using the numeric rating scale, and additional evaluation of side‐to‐side equivalence (symmetry) was described using a binary system. Among the 184 participants, 60.8% (n = 112) did not exhibit clusters and among the 72 participants with clusters, 36.1% (n = 26) and 63.9% (n = 46) were in the high and low RMMA frequency groups, respectively. The high SB group had significantly three times more phasic RMMA events than the noncluster group. A total of 89.67% (n = 165) of subjects reported orofacial muscle pain. While there was no difference in the severity of OFMP among groups, a significant decrease in symmetry between the severity of temporal muscle pain on the left and right sides was noted in the cluster group compared with the noncluster group. Clustering of RMMA events is associated with sleep fragmentation. The asymmetry of temporal muscle pain is related to the presence of RMMA clusters in sleep bruxism.
Ruthless times—Songs of care: Crisis in older people care sector
Authors: Cubelo Floro 
Published: October 2023

AbstractBackgroundThe Finnish‐language documentary, “Ruthless Times ‐ Songs of Care,” highlighted the challenges of older people care in Finland. Through a blend of choral scenes and documentary footage, it exposed the ethical and economic disparities in caregiving.ObjectiveTo provide a narrative of the documentary and its implications in the older people care sector.MethodsMedia review.ResultsThe film explored the consequences of nursing personnel shortages, showcasing the impact on patient care and nursing staff morale. It also featured a choir of nursing staff and pensioners, adding depth to the narrative.ConclusionThe documentary compellingly emphasized the intrinsic connection between the shortage of nursing staff and the quality of care within the older people community, advocating for a holistic approach to improve older people care within the Finnish social and healthcare framework.Implications for practiceThere is a need for systemic reforms and increased support for nursing staff to enhance the quality of care for older people in Finland.
Nursing home managers' descriptions of multi‐level barriers to leading person‐centred care: A content analysis
Authors: Backman Annica , Ahnlund Petra , Lövheim Hugo , Edvardsson David 
Published: October 2023

AbstractBackgroundResearch suggests that person‐centred care can be beneficially implemented and sustained, even though barriers remain that prevent uptake in clinical practice. Understanding barriers to person‐centred care seems important, as this has an impact on care practices and resident outcomes. Moreover, there is limited knowledge about nursing home managers' descriptions of barriers when leading person‐centred care.ObjectivesTo explore barriers to leading person‐centred care as narrated by nursing home managers.MethodsA descriptive qualitative design was used to collect data using individual interviews with 12 nursing home managers in highly person‐centred nursing homes. Data were analysed using content analysis.ResultsMulti‐level barriers to leading person‐centred care were identified on the (1) person level, (2) team level and (3) organisational level. Placing professional and family considerations ahead of resident considerations was described as a barrier on the personal level (1). Also, staff's divergent care values, processes, and priorities together with turnover and low foundational knowledge were identified as barriers on the team level (2). On an organisational level (3), constrained finances, functional building design and group level rostering were identified as barriers.ConclusionMulti‐level barriers influence nursing home managers' ability to lead and promote person‐centred care. Promoting the development of person‐centred practices requires efforts to eliminate barriers on person, team and organisational level.Implications for PracticeIdentifying and overcoming barriers at various levels in nursing home care has the potential to promote person‐centred practices. This study can inform stakeholders and policymakers of challenges and complexities in person‐centred practices. Multi‐level strategies are needed to target challenges at person‐, team‐ and organisational level when striving to develop person‐centred care.