bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disease Response Assessment Modalities in Chronic Myeloid Leukemia: Past, Present, and Future
Authors: Mishra Deepak Kumar , Dey Indranil , Demde Rakesh , Vinarkar Sushant , Parihar Mayur 
Published: November 2023

AbstractChronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by the BCR::ABL1 fusion gene, which results from a reciprocal translocation between chromosome 9 and 22 t(9;22)(q34;q11). The use of tyrosine kinase inhibitor (TKI) against the chimeric BCR::ABL1 fusion protein has led to a paradigm shift in CML patient outcomes. Despite generational advancements in TKI, a fraction of patients harbor residual disease or exhibit resistance to TKI. The importance of disease monitoring and detection of resistance mechanisms has gained prominence with increasing knowledge about disease evolution. In the past, cytogenetic techniques such as karyotyping and fluorescence in situ hybridization were widely utilized for monitoring disease and prognostication. These techniques had various challenges related to limited sensitivity in minimal residual disease (MRD) monitoring; however, their importance still holds in the detection of additional chromosomal aberrations and in cases with cryptic insertions, variants, and masked Philadelphia chromosome. Molecular genetics has evolved significantly from the past to the present times for MRD monitoring in CML patients. Qualitative reverse transcription polymerase chain reaction (RQ-PCR) can be performed at diagnosis to detect the BCR::ABL1 transcript, while quantitative RQ-PCR is the most widely used and well-standardized MRD monitoring method. The DNA-based assays demonstrated high sensitivity and specificity, with many efforts directed toward making the laborious step of BCR::ABL1 breakpoint characterization less tedious to increase the utility of DNA-based MRD approach in the future. Flow cytometric–based approaches for the detection of the BCR::ABL1 fusion protein have been under trial with a scope of becoming a more robust and convenient methodology for monitoring in the future. Upcoming techniques such as digital PCR and ultra-deep sequencing next-generation sequencing (UDS-NGS) have shown promising results in residual disease monitoring and detection of resistance mutations. Novel MRD monitoring systems that are independent of BCR::ABL1 fusion such as the detection of CD26+ leukemic stem cells and microRNA mutations are the future of residual disease monitoring, which can go up to the level of a single cell. In this review, we tried to discuss the evolution of most of the above-mentioned techniques encompassing the pros, cons, utility, and challenges for MRD monitoring and detection of TKI resistance mutations.
Assessment of Functional Outcome Following Duhamel Retro-Rectal Pull-Through Surgery for Hirschsprung's Disease - A Follow-up Study
Authors: M. Raghunath S. , Maniam Raghul , Dhanasekarapandian Vembar , Govindarajan Hariharan 
Published: November 2023

Abstract
Context Hirschsprung's disease (HD) is one of the commonest problems requiring surgery in children. More than 95% of children present during new-born period, when they are treated with leveling colostomy and are followed with pull-through surgery a few months later, once the child has gained adequate weight to withstand a major surgery. The commonest pull through surgery done is the Duhamel retro-rectal pull-through (DRPT) repair.
Settings and Design This is a retrospective study of children who presented to one unit in our institute, a tertiary care referral hospital for children less than 12 years, with HD and underwent DRPT procedure during the period between July 2017 to June 2020. The children were evaluated after three years of follow-up for fecal incontinence and constipation. The study was conducted in children diagnosed with classical segment recto-sigmoid HD who underwent surgery. The children who were diagnosed with HD other than classical segment, who underwent primary pull through surgery and who underwent other repairs for HD were excluded from the study.
Results Thirty-two children underwent DRPT procedure during the study period. Of them, five (15.6%) children were lost on follow-up and one (3.1%) child had expired in the immediate post-operative period. Twenty-six children were included in the study. The bowel function score was calculated. The mean age of definitive surgery was 4.2 years. The follow-up period was a minimum of three years. Only two children had a “good” score of eighteen and above. Nineteen children had a “fair” score of 13–17. Five children had a “poor” score of less than thirteen, and among them, two had a “very poor” score of less than nine. The mean BFS was 13.72.
Conclusions Functional outcomes following Duhamel procedure are satisfactory, with 7.7% of children are in the fringe of requiring another surgery for constipation and pseudo-incontinence.
Laparoscopic Cecectomy for Diseases of the Appendix and Cecum
Authors: Oner Muharrem , Abbas Maher A. 
Published: November 2023

Abstract
Introduction The cecum is the first part of the large bowel. Cecectomy is a sufficient treatment for some patients, avoiding overtreatment by ileocolic resection.
Purpose The goal of this study was to review a surgeon's experience with laparoscopic cecectomy and provide a technical video demonstration of this uncommon operation.
Methods A retrospective chart review was conducted of all consecutive patients treated with laparoscopic cecectomy over a 16-year period. All operations were performed using a 3-trocar technique. The cecum was transected with 1 to 2 firings of a 60 millimeters linear stapler, preserving the ileocecal valve and ascending colon.
Results 19 patients were identified including 12 females (63.2%). Median age was 42 years (range 16-84). Indication for surgery included appendiceal pathology in 12 patients (63.2%) and cecal abnormality in 7 (38.9%). There was no conversion to open surgery. Median intraoperative blood loss was 25 ml (range 0-150 ml) and no patient received a blood transfusion. No intraoperative or postoperative complication was noted. The median length stay was 1 day (range 0-6). Readmission rate was 0%. Final appendiceal histopathology revealed acute/chronic appendicitis in 5 patients, mucinous cystadenoma in 4 patients. Cecal histopathology revealed adenoma in 4 patients. Median follow-up was 16 months (range 4-53).
Conclusions Laparoscopic cecectomy is a sufficient treatment for some patients with benign conditions of the appendix and cecum. It carries minimal morbidity. It should be considered as an alternative to segmental bowel resection in a select group of patients.
Assessment of Quality-of-Life in Cancer Patients at Tertiary Care Hospital in North India
Authors: Sharma Bintoo , Tyagi Harsh , Kumar Ranjeet , Sharma Amit 
Published: November 2023

Abstract
Introduction Cancer is a disease that emerges as a result of abnormal cell proliferation and their propensity to spread from one bodily region to another. There are over a hundred different types of cancer that impact individuals all over the world. It is difficult to identify in the early stages, but there are certain warning signals that the cells will turn malignant. Quality of life (QOL) is described by the World Health Organisation as “individuals' perception of life, values, objectives, standards, and interests within the cultural framework of the social environment in which they live and in relation to their goals, expectations, standards, and concerns.” QOL assessment in health system is a multidimensional construct that can be measured by evaluating objective levels of health status filtered by the subjective perceptions and expectations of the individual.
Aim and Objective To assess socio-demographic factors and quality of life among cancer patients in tertiary care hospital.
Materials and Methods A hospital-based prospective observational study was conducted at Guru Gobind Singh Medical College and Hospital Faridkot district, Punjab (India). The study was conducted for a period of six months after getting approval from Institutional Ethical Committee (IEC). Generic instrument, SF-36 was used to assess the QOL. The study was analyzed on SPSS version 26.0 software. Descriptive and analytical analysis was used to describe the results.
Results Linear regression was conducted to see the relationship of physical functioning score with age and weight of the patients. The descriptive statistics shows the mean and standard deviation of the variable. The mean of physical functioning score was found to be (M = 27.82, SD = 15.635). The physical functioning score and age, weight of the patients in linear regression shows that the age and weight explain 17.5%
Conclusion Treatment revealed that severe and moderate activities restricted nearly half of the assessed patients, with body pain interfering with employment and routine activities. According to the findings of the current study, QOL deteriorates as the disease progresses. Cancer unquestionably has a detrimental influence on patients' quality of life, which is connected to the illness process itself, the therapy administered, and the length of the disease.
Cultural worldviews and support for governmental management of COVID-19
Authors: Guo Qi , Muhetaer Palizhati , Hu Ping 
Published: November 2023

AbstractThis article addresses public attitudes towards government measures to contain preventable diseases in China in light of personal privacy and social safety controversies. Using a nationwide Internet survey of 776 Chinese adults and an online worldview database, we seek to explain the reason for causing differing public opinions on prevention policies and related governance issues. As Cultural Theory suggests, cultural biases impact public attitudes toward social policies. However, to our knowledge, culture theory has rarely been used to explain public differences in policies in China. So, study 1 conducted an exploratory and confirmatory factor analysis and found that the four-factor model of cultural worldviews: egalitarianism, hierarchy, individualism, and fatalism is still a feasible assessment tool for worldviews. Then, in studies 2–4, we explored how cultural worldviews influence Chinese public policy support. Study 2 involved an online worldview database and found that by trusting the government, hierarchists trust the policies proposed by the government. Study 3 and Study 4, based on the revised cultural scale in Study 1 and surveys during the epidemic period, found that compared to hierarchists and egalitarians, fatalists and individualists were less likely to support COVID-19 responses. In study 3, we further found that along with the risk perception levels growing, fatalists’ resistance towards epidemic prevention policies will disappear under high-risk perception conditions. Study 4 also found that hierarchists and egalitarians with higher trust in government tend to support COVID-19 responses. Hierarchists will be more supportive of the government with the increased public’s perceived threats. In conclusion, cultural worldviews have different impacts on policy support, and the relationship between cultural worldviews and policy support is influenced by public attitudes toward authorities and the perceived threats they face. Lastly, risk management and communication implications are discussed, such as establishing trust between individuals and authorities.
The development of children’s autonomy and reasonable paternalistic intervention
Authors: Ke Ting 
Published: November 2023

AbstractChildren are often perceived as beings who have very little or lack autonomy. The core of liberal education theory is to emphasize individual freedom and equality. In the context of liberal education, the purpose of education is to develop children’s autonomy, which is in conflict with paternalistic intervention in education. This article defends that children have a degree of autonomy through an analysis of the concept and conditions of autonomy from a philosophical point of view. Furthermore, this paper demonstrates the compatibility of children’s autonomy with adults’ paternalistic intervention from the aspects of children’s choice, respect for autonomy and future-oriented education. In the end, this paper proposes what is reasonable paternalism, that is, reasonable paternalism should be based on the moral equality of children and adults; reasonable paternalism should follow the principle of taking children as the center; reasonable paternalism is mainly achieved through the participation of children.
The road to language through gesture
Authors: Wille Beatrijs , Nyffels Hilde , Capirci Olga 
Published: November 2023

Abstract
This study explores the role of gestures in Flemish Sign Language (VGT) development through a longitudinal
observation of three deaf children’s early interactions. These children were followed over a period of one and a half year, at the
ages of 6, 9, 12, 18 and 24 months. This research compares the communicative development of a deaf child growing up in a deaf
family and two deaf children growing up in hearing families. The latter two children received early cochlear implants when they
were respectively 10 and 7 months old. It is the first study describing the types and tokens of children’s gestures used in early
dyadic interactions in Flanders (Belgium). The description of our observations shows three distinct developmental patterns in
terms of the use of gestures and the production of combinations. The study supports the finding that children’s gestural output is
subject to their parental language, and it further indicates an impact of age of cochlear implantation.
Mechanical, magneto-electronic and thermoelectric properties of Ba2MgReO6 and Ba2YMoO6 based cubic double perovskites: an ab initio study
Authors: Ketfi Mohammed Elamin , Essaoud Saber Saad , Al Azar Said M , Al-Reyahi Anas Y , Mousa Ahmad A , Al-Aqtash Nabil 
Published: November 2023

Abstract
We report an analysis of the structural, electronic, mechanical, and thermoelectric properties of oxide double perovskite structures, specifically the compounds Ba2MgReO6 and Ba2YMoO6. Our study employs first-principles density functional theory (DFT) as the investigative methodology. The electronic attributes of the examined compounds are explained by investigating their energy bands, as well as the total and partial density of states. The computational evaluation of the electronic band structure reveals that both compounds exhibit an indirect band gap semiconductor behavior in the spin-down channel, while demonstrating metallic properties in the spin-up channel. The magnetic attributes indicate a ferromagnetic nature, thus categorizing some double perovskite compounds as materials displaying half-metallic ferromagnetism (HM-FM) in addition to some other properties such as metallic and semiconductor in paramagnetic or antiferromagnetic states. The outcomes derived from the analysis of elastic constants confirm the mechanical robustness of the studied double perovskite compounds. Notably, the computed data for bulk modulus (B), shear modulus (G), and Young’s modulus (E) for Ba2MgReO6 surpass those of Ba2YMoO6. The calculated ratio of Bulk to shear modulus (B/G) indicates that both compounds possess ductile characteristics, rendering them suitable for device fabrication. Furthermore, both compounds display outstanding electronic and elastic properties, positioning them as promising contenders for integration within mechanical and spintronic devices. Finally, we investigate into the thermoelectric potential by evaluating parameters such as the Seebeck coefficient, electrical conductivity, thermal conductivity, figure of merit, and power factor. This assessment is conducted using the semiclassical Boltzmann theory and the constant relaxation time approximation, implemented through the BoltzTraP code. The results indicate that the investigated double perovskite oxides hold promise for utilization in thermoelectric applications.
120 nm wide band tunable pulsed laser generation employing vanadium carbide MXene/polyvinyl alcohol (V2C-PVA) film
Authors: Ahmad Harith , Makhfuz Maryam Jasmine Mohd , Yusoff Norazriena , Albaqawi Hissah Saedoon 
Published: November 2023

Abstract
MXene, a group of 2D materials, has garnered significant attention from researchers due to its impressive characteristics, such as large surface area, high metallic conductivity, and strong nonlinear saturable absorption. These properties make MXene an excellent material for exploring new possibilities in ultrafast photonics technology. The present study has demonstrated that vanadium carbide (V2C) MXene can function as a saturable absorber (SA) and effectively generate Q-switching pulses in the 1.9 μm wavelength region. The molten salt synthesis method was used to synthesize V2C MXene, which involved the selective etching of aluminum (Al) layers from the V2AlC MAX Phase precursor. The V2C MXene was transformed into a thin film by mixing it with polyvinyl alcohol (PVA) using a solution casting technique. The resulting V2C-PVA film was found to have saturable absorption properties, with a modulation depth of 8% and saturation intensity of 1.6 MW cm −2. Upon integrating the V2C-PVA film into the Thulium/Holmium-doped fiber laser (THDFL) cavity, stable Q-switching pulses were realized at a central wavelength of 1896.9 nm with 13.9 nm of 3-dB spectral bandwidth. At the maximum pump power of 448.7 mW, the 2.2 μs of pulse duration, 58.26 kHz of repetition rate, and 31 nJ of pulse energy were achieved. By adjusting the tunable bandpass filter (TBPF) integrated within the THDFL cavity, the system has a tunable spectral range of approximately 120.75 nm, from 1889.75 nm to 2010.5 nm. The exceptional performance of V2C-based SA for Q-switching operation showcases the immense potential of other MXene materials in the future of photonics applications.
Raman reference database for organic molecules by using a Coupled-Optical Fiber Raman Spectrograph
Authors: Salinas-Luna Javier , Mentado-Morales Juan 
Published: November 2023

Abstract
In this work, an overview of a reference spectral database for diverse organic molecules often used in a chemistry laboratory is shown. Obtained typical Raman signals have been well-resolved within a range from 0 to 3250 cm−1 by using a Coupled-Optical Fiber Raman Spectrograph, COFRS, performing with a sample holder for liquids connected to optical fiber in its typical configuration and an excitation wavelength of 785 ηm. This optical device works by using some spectral acquisition parameters, as integration time, signal average, boxcar or signal smoothing, detector gain and laser variable output power. These last parameter was varied in each compound due to the different purity presented for each organic molecule, and so a higher Raman signal can be obtained. We have included some of the most typical organic molecules used. Further, the main idea is to show a Raman spectral collection for rapid molecular identification of the diverse functional groups related to organic molecules.
Light trajectories and thermal shadows casted by black holes in a cavity
Authors: Belhaj A. , Belmahi H. , Benali M. , Oualaid M. , Sedra M.B. 
Published: November 2023

Abstract
We explore the shadows and the photon rings casted by black holes in cavity. Placing the
observer inside such an isothermal background, we examine the influence of the cavity
temperature T
cav and the charge Q on the involved optical features. After
studying the effect of the horizon radius by varying Q, we investigate the thermal
behaviors of the black hole shadows in a cavity. For fixed charge values, we find that the
shadow radius r
s increases by decreasing T
cav. Varying such a temperature, we
discuss the associated energy emission rate. After that, we show that the curves in the r
s-T
cav plane share similarities with the G-T curves of the Anti de Sitter black
holes. Then, we study the trajectories of the light rays casted by black holes in a cavity.
We further observe that the light trajectory behaviors are different than the ones of the
non rotating black holes due to the cavity effect. Finally, we provide an evidence for the
existence of an universal ratio defined in terms of the photon sphere radius and the impact
parameter. Concretely, we obtain an optical ratio b
sp/r
sp∼√(3).
Symmetry-resolved entanglement in fermionic systems with dissipation
Authors: Murciano Sara , Calabrese Pasquale , Alba Vincenzo 
Published: November 2023

Abstract
We investigate symmetry-resolved entanglement in out-of-equilibrium fermionic systems subject to gain and loss dissipation, which preserves the block-diagonal structure of the reduced density matrix. We derive a hydrodynamic description of the dynamics of several entanglement-related quantities, such as the symmetry-resolved von Neumann entropy and the charge-imbalance-resolved fermionic negativity. We show that all these quantities admit a hydrodynamic description in terms of entangled quasiparticles. While the entropy is dominated by dissipative processes, the resolved negativity is sensitive to the presence of entangled quasiparticles, and it shows the typical ‘rise and fall’ dynamics. Our results hold in the weak-dissipative hydrodynamic limit of large intervals, long times and weak dissipation rates.
Statistical physics of learning in high-dimensional chaotic systems
Authors: Fournier Samantha J , Urbani Pierfrancesco 
Published: November 2023

Abstract
In many complex systems, elementary units live in a chaotic environment and need to adapt their strategies to perform a task by extracting information from the environment and controlling the feedback loop on it. One of the main examples of systems of this kind is provided by recurrent neural networks. In this case, recurrent connections between neurons drive chaotic behavior, and when learning takes place, the response of the system to a perturbation should also take into account its feedback on the dynamics of the network itself. In this work, we consider an abstract model of a high-dimensional chaotic system as a paradigmatic model and study its dynamics. We study the model under two particular settings: Hebbian driving and FORCE training. In the first case, we show that Hebbian driving can be used to tune the level of chaos in the dynamics, and this reproduces some results recently obtained in the study of more biologically realistic models of recurrent neural networks. In the latter case, we show that the dynamical system can be trained to reproduce simple periodic functions. To do this, we consider the FORCE algorithm—originally developed to train recurrent neural networks—and adapt it to our high-dimensional chaotic system. We show that this algorithm drives the dynamics close to an asymptotic attractor the larger the training time. All our results are valid in the thermodynamic limit due to an exact analysis of the dynamics through dynamical mean field theory.