bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of machine learning models to predict the risk of breast cancer-related lymphedema among breast cancer survivors: a cross-sectional study in China
Authors: Du Jiali , Yang Jing , Yang Qing , Zhang Xin , Yuan Ling , Fu Bing 
Published: February 2024

ObjectiveThe aim of this study was to develop and validate a series of breast cancer-related lymphoedema risk prediction models using machine learning algorithms for early identification of high-risk individuals to reduce the incidence of postoperative breast cancer lymphoedema.MethodsThis was a retrospective study conducted from January 2012 to July 2022 in a tertiary oncology hospital. Subsequent to the collection of clinical data, variables with predictive capacity for breast cancer-related lymphoedema (BCRL) were subjected to scrutiny utilizing the Least Absolute Shrinkage and Selection Operator (LASSO) technique. The entire dataset underwent a randomized partition into training and test subsets, adhering to a 7:3 distribution. Nine classification models were developed, and the model performance was evaluated based on accuracy, sensitivity, specificity, recall, precision, F-score, and area under curve (AUC) of the ROC curve. Ultimately, the selection of the optimal model hinged upon the AUC value. Grid search and 10-fold cross-validation was used to determine the best parameter setting for each algorithm.ResultsA total of 670 patients were investigated, of which 469 were in the modeling group and 201 in the validation group. A total of 174 had BCRL (25.97%). The LASSO regression model screened for the 13 features most valuable in predicting BCRL. The range of each metric in the test set for the nine models was, in order: accuracy (0.75–0.84), sensitivity (0.50–0.79), specificity (0.79–0.93), recall (0.50–0.79), precision (0.51–0.70), F score (0.56–0.69), and AUC value (0.71–0.87). Overall, LR achieved the best performance in terms of accuracy (0.81), precision (0.60), sensitivity (0.79), specificity (0.82), recall (0.79), F-score (0.68), and AUC value (0.87) for predicting BCRL.ConclusionThe study established that the constructed logistic regression (LR) model exhibits a more favorable amalgamation of accuracy, sensitivity, specificity, recall, and AUC value. This configuration adeptly discerns patients who are at an elevated risk of BCRL. Consequently, this precise identification equips nurses with the means to undertake timely and tailored interventions, thus averting the onset of BCRL.
A bibliometric analysis of literatures on uterine leiomyosarcoma in the last 20 years
Authors: Huang Jinhua , Chen Yu , Li Ziyin , Chen Mimi , Huang Dingwen , Zhu Peixin , Han Xintong , Zheng Yi , Chen Xiaochun , Yu Zhiying 
Published: February 2024

BackgroundUterine leiomyosarcoma(uLMS) is a rare malignant tumor with low clinical specificity and poor prognosis.There are many studies related to uLMS, however, there is still a lack of metrological analyses with generalization. This study provides a bibliometric study of uLMS.Methods and materialsWe chose the Web of Science (WoS) as our main database due to its extensive interdisciplinary coverage. We specifically focused on the literature from the last 20 years to ensure relevance and practicality. By utilizing the WOS core dataset and leveraging the R package “bibliometric version 4.1.0” and Citespace, we performed a comprehensive bibliometric analysis. This allowed us to pinpoint research hotspots and create visual representations, resulting in the retrieval of 2489 pertinent articles.ResultsThis literature review covers 2489 articles on uterine leiomyosarcoma (uLMS) from the past 20 years. Key findings include an average annual publication rate of 8.75, with a 6.07% yearly growth rate and an average citation count of 17.22. Core+Zone 2 sources contributed 1079 articles and 207 reviews, displaying a 4.98% annual growth rate. The analysis identified top journals, influential authors, and core sources, such as the prevalence of publications from the United States and the dominance of GYNECOLOGIC ONCOLOGY and HENSLEY ML. Bradford’s Law and Lotka’s Law highlighted core sources and author productivity, respectively. Thematic mapping and factorial analysis revealed research clusters, including etiology, diagnosis, treatment advancements, and surgical approaches, with prominent themes such as gemcitabine and docetaxel. Overall, this comprehensive analysis provides insights into uLMS literature trends and influential factors.ConclusionThis thorough bibliometric analysis, in its whole, illuminates the field’s guiding principles while also revealing the subtle patterns within the uLMS literature. The knowledge gained here contributes to the current discussion in uLMS and related scientific fields and provides a solid basis for future research paths.
Could sex-specific subtypes of hand osteoarthritis exist? A retrospective study in women presenting to secondary care
Authors: Gulati Malvika , Brewer Gretchen , Judge Andrew , Kennedy Donna , Vincent Tonia L. , Watt Fiona E. 
Published: February 2024

IntroductionHand osteoarthritis is more common in women, and its risk increases around the time of the menopause. We set out to describe the timing between menopause and the onset of symptomatic hand osteoarthritis (OA), and associations with the use of hormone replacement therapy (HRT) or its discontinuation, describing any identifiable subgroups of women.MethodsRetrospective healthcare-records study of sequential women referred to a specialist hand OA clinic, 2007–2015. Confirmation of hand OA diagnosis was by clinican, by accepted criteria. Demographics and clinical variables were from healthcare-records, recorded by standardised proforma. Outcomes of interest were reported age of onset of hand symptoms, reported age at final menstrual period (FMP), time from FMP to reported onset of hand symptoms and time from cessation of HRT to reported onset of hand symptoms. Exposure categories for systemic HRT use were never users, current users, previous users. Analysis of Variance compared groups; linear regression analysed associations of exposure with outcome.Results82/92(89%) of eligible women were post-menopausal, mean age at FMP 49.9 years (SD5.4). In these post-menopausal women, median time from FMP to hand symptom onset was 3 years. 48/82 (59%) developed hand symptoms within the defined peri-menopausal period (FMP ± 4 years), whilst some women developed their symptoms before or after (range −25, 30 years). In women who discontinued HRT prior to symptom onset, the median time from HRT cessation to onset of hand symptoms was 6 months. Past HRT users were older at hand symptom onset than women who had not taken HRT [coeff.4.7 years (0.92, 8.39); P = 0.015].ConclusionsThis study adds to evidence associating the menopause/sex hormone deficiency with hand OA symptom onset in a sizeable subgroup of women (but not all). HRT use/cessation appears to influence the timing of onset of hand OA symptoms. It is not possible to interpret from this type of study whether sex hormone deficiency is causative of disease or modulates its symptoms. It is also not possible to judge whether painful hand osteoarthritis in post-menopausal women is a subtype of disease. Further investigation is indicated of sex-specific subtypes and potential for personalised medicine for post-menopausal women with hand osteoarthritis, as a clearly definable high-risk subgroup.
Frequency of SARS-CoV-2 variants identified by real-time PCR in the AUNA healthcare network, Peru
Authors: Ortiz-Gómez Tamin , Gomez Andrea C. , Chuima Brigitte , Zevallos Alejandra , Ocampo Karen , Torres Diana , Pinto Joseph A. 
Published: February 2024

IntroductionIn Peru, on 11 February 2023, the Ministry of Health registered 4 million patients infected with COVID-19 and around 219,260 deaths. In 2020, the SARS-CoV-2 virus was acquiring mutations that impacted the properties of transmissibility, infectivity, and immune evasion, leading to new lineages. In the present study, the frequency of COVID-19 variants was determined during 2021 and 2022 in patients treated in the AUNA healthcare network.MethodsThe methodology used to detect mutations and identify variants was the Allplex™ SARS-CoV-2 Variants Assay I, II, and VII kit RT-PCR. The frequency of variants was presented by epidemiological weeks.ResultsIn total, 544 positive samples were evaluated, where the Delta, Omicron, and Gamma variants were identified. The Delta variant was found in 242 (44.5%) patients between epidemiological weeks 39 and 52 in 2021. In the case of Gamma, it was observed in 8 (1.5%) patients at weeks 39, 41, 43, 45, and 46 of 2021. The Omicron variant was the most frequent with 289 (53.1%) patients during weeks 49 to 52 of 2021 and 1 to 22 of 2022. During weeks 1 through 22 of 2022, it was possible to discriminate between BA. 1 (n = 32) and BA.2 (n = 82).ConclusionThe rapid identification of COVID-19 variants through the RT-PCR methodology contributes to timely epidemiological surveillance, as well as appropriate patient management.
Sex-specific association of low-renin hypertension with metabolic and musculoskeletal health in Korean older adults
Authors: Lee Seunghyun , Chang Jae Seung , Park Kyu-Sang , Koh Sang-Baek , Kim Moon Young , Lim Jung Soo 
Published: February 2024

IntroductionLow-renin hypertension (LRH) accounts for approximately one-third of patients with hypertension and are more prevalent in women and the older adult population. Previous study has found a link between the renin-angiotensin-aldosterone system (RAAS) and sex hormones. However, there are insufficient data on the relationship between LRH and metabolic or musculoskeletal outcomes in older adults.Methods and materialsAmong the 343 participants from a population-based cohort study conducted between May 2018 and August 2019, a total of 256 (86 men older than 50 years and 170 postmenopausal women) were included. The presence of LRH was defined as plasma renin activity (PRA) &lt;1 ng/mL/h and systolic blood pressure (BP) ≥130 or diastolic BP ≥80 mmHg based on the 2017 ACC/AHA guidelines. Individuals with missing data, and those who had used medications that could affect PRA within the past six months were excluded. Bone mineral density (BMD), trabecular bone score (TBS), and appendicular lean mass (ALM) index were assessed using dual-energy X-ray absorptiometry; degraded TBS was defined as partially degraded to degraded levels (≤1.350). Muscle function was assessed according to the Asian Working Group for Sarcopenia guidelines. PRA was measured using radioimmunoassay.ResultsThe median age was 66 [61–72] years, and the body mass index (BMI) was 24.7 [23.0–26.4] kg/m2. Individuals with LRH, accounting for 34.8%, had lower diabetes mellitus; more dyslipidemia; and poorer muscle function, BMD, and TBS than those in the non-LRH group. In addition, PRA was positively correlated with C-peptide, HOMA-IR, TBS, and ALM index. After adjusting for covariates including age and BMI, LRH was negatively associated with femur neck T-score (adjusted β = −0.30, 95% CI [−0.55 to −0.05], p = 0.021) and the presence of LRH was significantly associated with degraded TBS in women (adjusted odds ratio = 3.00, 95% CI [1.36–6.58], p = 0.006).ConclusionOur findings suggest that LRH can influence clinical features and metabolic risk in older adults. Notably, LRH in postmenopausal women was linked to lower femur neck T-scores and degraded TBS, indicating sex-specific effects of LRH on bone health. Larger prospective studies are required to elucidate how changes in the RAAS affect metabolic and musculoskeletal outcomes in older adults.
Epichloë bromicola Enhances Elymus dahucirus Plant Growth and Antioxidant Capacity under Cadmium Stress
Authors: Shi Qian , Simpson Wayne R. , Li Yuling , Xu Chengti , De Kejia , Li Xiuzhang 
Published: February 2024

Elymus dahucirus is an essential plant for ecological restoration in fragile ecological areas and mining area restoration. As lawn grass, it can quickly cover soil and prevent soil erosion, so it is commonly used as a pioneer grass for lawn greening and slope protection. In recent years, with the development of mineral resources, Qinghai–Tibet Plateau soil is facing the threat of heavy metal cadmium (Cd) pollution. E. dahuricus can host the filamentous fungus Epichloë bromicola. To make better use of the advantages that Epichloë bring to host plants to alleviate heavy metal pollution in soil, plant growth and antioxidant capacity effects on E. bromicola infected (E+) and uninfected (E−) E. dahuricus were determined under Cd stress. During Cd treatment, plant growth was decreased by Cd stress, while E+ plants exhibited equal or better growth compared to E− plants. Cd treatment induces a proline and antioxidant enzyme burst in infected plants, while malondialdehyde (MDA) increases. E. bromicola improved plant growth and antioxidant capacity. E. dahuricus breeding strategies could use the information here in efforts to improve the performance of E. dahuricus in both environmental protection and agronomic contexts.
Inhibitory Effects of Bacillus subtilis Isolated from Meju (Fermented Soybean Brick) on the Growth of Aspergillus parasiticus
Authors: Kim Jong-Gyu , Park Jeong-Yeong 
Published: February 2024

Background: Meju is a base material for making soy sauce, soybean paste, and red chili pepper paste, which are representative ingredients of Korean cuisine. Objectives: This study aimed to isolate a predominant bacterial strain of B. subtilis from meju and to observe its inhibitory effects on an aflatoxigenic mold. Methods: We used yellow soybeans (Glycine max (L.) Merr.) grown in South Korea, and meju was produced according to the recommended methods of the Korea Food Research Institute. The identification of the strain was conducted based on its morphological and biochemical characteristics and 16S rDNA sequence. Evaluation of the bacterial effect against A. parasiticus ATCC 15517 was done in yeast extract–sucrose broth at 28 °C. Its inhibitory effect was evaluated using two approaches: mycelial weight and aflatoxin production. Aflatoxins were determined using high-performance liquid chromatography. Results: In the meju samples fermented for three months, a B. subtilis strain, K-0924 was identified. At the end of the incubation period of A. parasiticus, dry mycelial weight was significantly reduced by more than 80% (p < 0.01) and total aflatoxin production was inhibited by more than 63% (p < 0.05) in the presence of B. subtilis. Conclusions: These results indicate that B. subtilis K-0924 inhibits the growth and aflatoxin production of toxigenic Aspergillus, which can be contaminated with meju. We could expect more inhibition by other bacteria related to fermentation of meju, and further examination is necessary on species other than B. subtilis.
Antibiotic Combination to Effectively Postpone or Inhibit the In Vitro Induction and Selection of Levofloxacin-Resistant Mutants in Elizabethkingia anophelis
Authors: Lee Ching-Chi , Lai Chung-Hsu , Yang Chih-Hui , Huang Yi-Han , Lin Jiun-Nong 
Published: February 2024

Fluoroquinolones are potentially active against Elizabethkingia anophelis. Rapidly increased minimum inhibitory concentrations (MICs) and emerging point mutations in the quinolone resistance-determining regions (QRDRs) following exposure to fluoroquinolones have been reported in E. anophelis. We aimed to investigate point mutations in QRDRs through exposure to levofloxacin (1 × MIC) combinations with different concentrations (0.5× and 1 × MIC) of minocycline, rifampin, cefoperazone/sulbactam, or sulfamethoxazole/trimethoprim in comparison with exposure to levofloxacin alone. Of the four E. anophelis isolates that were clinically collected, lower MICs of levofloxacin were disclosed in cycle 2 and 3 of induction and selection in all levofloxacin combination groups other than levofloxacin alone (all p = 0.04). Overall, no mutations were discovered in parC and parE throughout the multicycles inducted by levofloxacin and all its combinations. Regarding the vastly increased MICs, the second point mutations in gyrA and/or gyrB in one isolate (strain no. 1) occurred in cycle 2 following exposure to levofloxacin plus 0.5 × MIC minocycline, but they were delayed appearing in cycle 5 following exposure to levofloxacin plus 1 × MIC minocycline. Similarly, the second point mutation in gyrA and/or gyrB occurred in another isolate (strain no. 3) in cycle 4 following exposure to levofloxacin plus 0.5 × MIC sulfamethoxazole/trimethoprim, but no mutation following exposure to levofloxacin plus 1 × MIC sulfamethoxazole/trimethoprim was disclosed. In conclusion, the rapid selection of E. anophelis mutants with high MICs after levofloxacin exposure could be effectively delayed or postponed by antimicrobial combination with other in vitro active antibiotics.
Transparent Structures for ZnO Thin Film Paper Transistors Fabricated by Pulsed Electron Beam Deposition
Authors: Gherendi Florin , Dobrin Daniela , Nistor Magdalena 
Published: February 2024

Thin film transistors on paper are increasingly in demand for emerging applications, such as flexible displays and sensors for wearable and disposable devices, making paper a promising substrate for green electronics and the circular economy. ZnO self-assembled thin film transistors on a paper substrate, also using paper as a gate dielectric, were fabricated by pulsed electron beam deposition (PED) at room temperature. These self-assembled ZnO thin film transistor source–channel–drain structures were obtained in a single deposition process using 200 and 300 µm metal wires as obstacles in the path of the ablation plasma. These transistors exhibited a memory effect, with two distinct states, “on” and “off”, and with a field-effect mobility of about 25 cm2/Vs in both states. For the “on” state, a threshold voltage (Vth on = −1.75 V) and subthreshold swing (S = 1.1 V/decade) were determined, while, in the “off” state, Vth off = +1.8 V and S = 1.34 V/decade were obtained. A 1.6 μA maximum drain current was obtained in the “off” state, and 11.5 μA was obtained in the “on” state of the transistor. Due to ZnO’s non-toxicity, such self-assembled transistors are promising as components for flexible, disposable smart labels and other various green paper-based electronics.
Solutions with a Flat Horizon in D Dimensions within the Cubic Form of f(Q) Gravity
Authors: Nashed Gamal Gergess Lamee 
Published: February 2024

Given the AdS/CFT relationship, the study of higher-dimensional AdS black holes is extremely important. Furthermore, since the restriction derived from f(Q)’s field equations prevents it from deriving spherically symmetric black hole solutions, the result is either Q′=0 or fQQ=0. Utilizing the cylindrical coordinate system within the context the cubic form of f(Q) theory while imposing the condition of a coincident gauge, we establish the existence of static solutions in D-dimensions. The power-law ansatz, which is the most practical based on observations, will be used in this study, where f(Q)=Q+12γQ2+13γQ3−2Λ and the condition D≥4 are met. These solutions belong to a new solution class, the properties of which are derived only from the non-metricity Q modification, since they do not have a general relativity limit. We examine the singularities present in the solutions by calculating the non-metricity and curvature invariant values. In conclusion, we compute thermodynamic parameters such as Gibbs free energy, Hawking temperature, and entropy. These thermodynamic calculations confirm that our model is stable.
Policy Innovation of The Cikolelet Village Government in Developing the Village into a Tourism Village
Authors: Rahmawati Rahmawati , Purnaweni Hartuti , Warsono Hardi , Yuniningsih Tri 
Published: February 2024

Policy innovations made by the Cikolelet Village Government to become a tourist village and various village development efforts are efforts to overcome various problems faced by the village government and the community. The policy innovation is to change from underdeveloped villages to developing and advanced villages in 2021 according to the Village Development Index indicators. In 2017 Cikolelet Village was designated as the first tourist village in Serang Regency. Policy innovation is a major part of the transformation process or creating irreversible transformations based on a set of new order principles. Indicators of policy innovation, namely the creation stage, design stage and implementation stage according to Robert and King, are used as an analysis knife as well as innovation attributes according to Rogers to complete the description of Cikolelet Village Government's policy innovation in developing tourist villages. The research method used is qualitative with a case study approach. Key informants consisted of the Cikolelet village head, Pokdarwis head Anindya Pramita, Bumdes director and Cikolelet village officials. Data analysis used source triangulation according to Miles and Huberman. The results showed that the innovation of tourism village development policies in Cikolelet Village has run optimally, marked by the achievement of the 2021 ADWI award as the Most Favorite Tourism Village and encouraging other tourism villages in Serang Regency to adopt Cikolelet Village's tourism development policy innovations.
Pengelolaan Kelas pada Mata Pelajaran Pendidikan Agama Islam di SMA Al-Kholidiyah Teluk Jambe
Authors: Erma Januarsih Nina , Nurlela Nurlela , Selawati Selawati , Syaefi Abdurahman Rizal syaefi abdurahman , Karnia Nia 
Published: February 2024

Penelitian ini bertolak dari adanya masalah dalam pengelolaan kelas di SMA Al-Kholidiyah Teluk Jambe seperti ada anak yang tidur pas jam pelajaran, memainkan HandPhone pada saat jam pelajaran, dan kondisi ruangan kelas yang sangat panas, oleh karena itu peneliti ingin mengetahui bagaimana pengelolaan kelas pada mata pelajaran Pendidikan Agama Islam di SMA Al-Kholidiyah Teluk Jambe. Penelitian ini menggunakan pendekatan kualitatif deksriptif, subjek penelitian guru Pendidikan Agama Islam. Teknik pengumpulan data yang digunakan adalah dengan wawancara, observasi, dan dokumentasi dengan metode analisis data, penyajian data dan menarik kesimpulan.
Hasil dari penelitian ini menunjukan bahwa 1. Perencanaan pengelolaan kelas ada beberapa yaitu mempersiapkan peraturan kelas, mempersiapkan kegiatan pembelajaran dengan menyiapkan absen, buku penilaian siswa, dan buku LKS siswa, 2. Pelaksanaan pengelolaan kelas bersifat fisik dimana ruang kelas tempat berlangsungnya pembelajaran sudah luas dan besar akan tetapi ruangan yang panas disebabkan oleh plafon terlalu rendah, pengaturan tenpat duduk berbaris berjajar, ventilasi dan pencahayaan yang sudah cukup. Pengelolaan bersifat non fisik tipe kepemimpinan guru , sikap guru dalam menghadapi siswa yang melanggar yaitu sabar, memberikan teguran dan memberikan nasihat agar tidak melanggar lagi. Suaru guru PAI juga sudah jelas terdengar. 3. Usaha pencegahan dalam mengatasi masalah pengelolaan kelas yaitu menunjukan sikap tanggap, memperhatikan semua siswa, dan menegur apabila ada yang melanggar, 4. Usaha penyembuhan dalam mengatasi masalah pengelolaan kelas yaitu menegur, memberi nasihat, dan memberi hukuman.