bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecotoxicity characterization assisted performance assessment of electro‐bioremediation reactors for nitrate and arsenite elimination
Authors: Fekete‐Kertész Ildikó , Pous Narcís , Feigl Viktória , Márton Rita , Berkl Zsófia , Ceballos‐Escalera Alba , Balaguer Maria D. , Puig Sebastià , Molnár Mónika 
Published: October 2023

AbstractThe performance of combined reduction of nitrate (NO3−) to dinitrogen gas (N2) and oxidation of arsenite (As[III]) to arsenate (As[V]) by a bioelectrochemical system was assessed, supported by ecotoxicity characterization. For the comprehensive toxicity characterization of the untreated model groundwater and the treated reactor effluents, a problem‐specific ecotoxicity test battery was established. The performance of the applied technology in terms of toxicity and target pollutant elimination was compared and analyzed. The highest toxicity attenuation was achieved under continuous flow mode with hydraulic retention time (HRT) = 7.5 h, with 95%, nitrate removal rate and complete oxidation of arsenite to arsenate.Daphnia magnaproved to be the most sensitive test organism. The results of theD. magnalethality test supported the choice of the ideal operational conditions based on chemical data analysis. The outcomes of the study demonstrated that the applied technology was able to improve the groundwater quality in terms of both chemical and ecotoxicological characteristics. The importance of ecotoxicity evaluation was also highlighted, given that significant target contaminant elimination did not necessarily lower the environmental impact of the initial, untreated medium, in addition, anomalies might occur during the technology operational process which in some instances, could result in elevated toxicity levels.
Dispensary personnel's views and experiences regarding oncologic cannabis and the counsel they offer adults with cancer
Authors: Nayak Manan M. , Chai Peter R. , Tung Stephanie , Tulsky James A. , Hammer Marilyn , Andrade Nicole , Braun Ilana M. 
Published: October 2023

AbstractBackgroundA minority of oncologists feel qualified to advise adults with cancer on issues pertaining to medicinal cannabis. Adults with cancer frequently access medicinal cannabis information from non‐medical sources such as cannabis dispensaries. We explored dispensary personnel's views and experiences regarding oncologic cannabis and the counsel they extend individuals with cancer.MethodsSnowball sampling in this qualitative study facilitated recruitment across 13 states (N = 26). Semi‐structured phone interviews ceased with thematic saturation. A multi‐stage thematic analysis combined inductive and deductive codes.ResultsOf the 26 dispensary personnel interviewed, 54% identified as female and 19% as non‐white. Median age was 40 years. A consensus emerged among participants concerning the botanical's efficacy for cancer‐related symptoms; less so regarding its antineoplastic potential. Principles for serving those with cancer included provision of client‐centered, symptom‐based, and trial‐and‐error approaches. Non‐inhalation modes of administration were generally recommended. No consensus was reached as to whether delta‐9‐tetrahydrocannabinal (THC)‐ or cannabidiol‐predominant products were preferable in this population. Challenges in oncologic advising included successfully identifying individuals with cancer at the dispensary counter, financial toxicity, the special treatment required for the THC‐naïve, and operating in the absence of standardized guidelines.ConclusionsThese informed assertions suggest that members of the oncologic community should grapple with the extent to which they feel comfortable with both the nature and degree of counsel adults with cancer receive through dispensaries.
Correlation between L‐amino acid transporter 1 expression and 4‐borono‐2‐18F‐fluoro‐phenylalanine accumulation in humans
Authors: Kashihara Tairo , Mori Taisuke , Nakaichi Tetsu , Nakamura Satoshi , Ito Kimiteru , Kurihara Hiroaki , Kusumoto Masahiko , Itami Jun , Yoshimoto Seiichi , Igaki Hiroshi 
Published: October 2023

AbstractBackgroundThe correlation between L‐type amino acid transporter 1 (LAT1) expression and 4‐borono‐2‐18F‐fluoro‐phenylalanine (18F‐FBPA) accumulation in humans remains unclear. This study aimed to investigate the correlation between LAT1 expression in tumor tissues and 18F‐FBPA accumulation in patients with head and neck cancer who participated in a clinical trial of 18F‐FBPA positron emission tomography (PET).MethodsAltogether, 28 patients with head and neck cancer who participated in a clinical trial of 18F‐FBPA PET at our institution between March 2012 and January 2018 were included. Correlations between standardized uptake values (SUVs); the maximum SUV (SUVmax), the mean SUV within a 1 cm3 sphere centered at a single point, that is, the SUVmax (SUVpeak), the minimum SUV (SUVmin), and the intensity of LAT1 expression (maximum and minimum LAT1 expressions) were investigated.ResultsWeak correlations were identified between SUVmax and LAT1 maximum score, SUVmin and LAT1 maximum score, and SUVmin and LAT1 minimum score (ρ = 0.427, 0.362, and 0.330, respectively). SUVmax and LAT1 minimum score, SUVpeak and LAT1 maximum score, and SUVpeak and LAT1 minimum score demonstrated moderate correlations (ρ = 0.535, 0.556, and 0.661, respectively). Boron neutron capture therapy (BNCT) was performed in 2 of the 4 patients with discrepancies between 18F‐FBPA accumulation and intensity of LAT1 expression, and the intensity of LAT1 expression was a better predictor of treatment response.Conclusion18F‐FBPA accumulation and the intensity of LAT1 expression demonstrated a moderate correlation; however, LAT1 expression may be a better predictor of treatment response of BNCT in patients with discrepancies.
Pre‐bariatric surgery acute kidney injury: Can this be prevented?
Authors: Leelaviwat Natnicha , Yingchoncharoen Pitchaporn , Thongpiya Jerapas , Abdelnabi Mahmoud , Mekraksakit Poemlarp 
Published: October 2023

Key Clinical MessagePre‐bariatric surgery dietary recommendations should take into account daily protein intake and other risk factors for kidney injury. This is important because a high protein intake can potentially lead to kidney injury.AbstractBariatric surgery has been shown to be a highly effective intervention for achieving weight loss and reducing obesity related‐comorbidities. Acute kidney injury (AKI) is considered one of the common complications in perioperative and post‐bariatric surgery. However, pre‐bariatric surgery AKI has never been reported. Several studies demonstrated that pre‐bariatric surgery weight loss improved surgical outcomes and decrease postoperative complications. Some diet regimens have been introduced including low‐caloric diet (LCD), very‐low caloric diet (VLCD), and very‐low caloric ketogenic diet (VLCKD). We present a patient who develops AKI after 10 days of having a high‐protein diet from a pre‐bariatric weight loss strategy.
Transient neonatal pustular melanosis: An unusual and challenging eruption
Authors: Boffa Michelle Marie , Borg Janine , Grech Marie‐Claire , Pace David , Montalto Simon Attard 
Published: October 2023

Key Clinical MessageTNPM is a benign, transient, neonatal pustulosis requiring no active treatment. Diagnosis is clinical, characterized by a vesiculopustular eruption, healing with residual hyperpigmented macules. Before diagnosing TNPM, serious conditions including skin infections should be excluded. This case was unusual in that vesiculobullae predominated, with a notable absence of simple pustules.
Silent sinus syndrome: A case report
Authors: Salari Samaneh , Anbiaee Najme , Baee Maryam Bozorgi 
Published: October 2023

Key Clinical MessageA 65‐year‐old patient was referred to the Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran, with left facial pain and numbness in the upper lip. Based on clinical examinations and radiographic investigations, the patient was diagnosed with silent sinus syndrome. This study discusses oral findings associated with silent sinus syndrome.
A novel mutation c.457C > T p.Q153 in the HMBS gene in a Mexican woman with acute intermittent porphyria
Authors: Malagon‐Rangel Jose , Solis Jose Gabriel , Zavala‐Jonguitud Luis Fernando , Basile‐Alvarez Martín Roberto , Malagon‐Liceaga Andrea 
Published: October 2023

Key Clinical MessageThe detection of a novel HMBS gene mutation (c.457C > T) in a Mexican woman with acute intermittent porphyria underscores the importance of expanding genetic analyses in diverse populations to improve diagnosis, management, and knowledge of the disease's clinical implications.AbstractAcute intermittent porphyria (AIP) is an autosomal dominant disorder caused by a deficiency in the enzymatic activity of porphobilinogen deaminase (HMBS), resulting in the accumulation of toxic heme metabolites. In this report, we present the case of a Mexican woman with AIP who experienced recurrent episodes of severe abdominal pain, weakness, vomiting, and insomnia. Despite the challenges in diagnosis and treatment, genetic analysis revealed a novel HMBS mutation, c.457C > T (p.Q153X), located in exon 9. This mutation induces a premature translational stop codon and had not been previously reported in medical literature among individuals with AIP. Remarkably, the patient exhibited a positive response to RNA interference therapy. We hypothesize that this novel HMBS mutation may potentially account for the more severe clinical presentation observed in this case. However, further research is necessary to establish a definitive link between this specific mutation and disease severity. The prevalence and genetic variants of AIP in Mexico remain largely unknown, underscoring the importance of conducting additional research and expanding genetic analyses to gain a better understanding of the clinical implications associated with these mutations.
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Authors: Suzuki Satoko , Santria Anas , Oyama Taiji , Akao Ken‐ichi , Ishikawa Naoto 
Published: October 2023

AbstractIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid‐shift approximation, in which the band profiles for left‐handed circularly polarized (lcp) and right‐handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexes can be regarded as an example of such cases, since the two degenerate emission states are split in a magnetic field and can undergo a structural deformation. Here, we investigated an alternative approach, where the lcp and rcp components are independently determined. This method, which we refer to as the direct‐separation approach, allows direct determination of the distribution of the two emission states as well as the orbital angular momentum . Using this approach, and the distribution were determined from MCD and MCPL spectra of a series of phthalocyanine complexes. Comparison of the two methods shows that the rigid‐shift and the direct‐separation approaches give practically equivalent results for the systems under study, but the latter is advantageous for systems where the former is not applicable.
Health care utilization by long‐term survivors of blood or marrow transplantation—A Bone Marrow Transplant Survivor Study report
Authors: Oliver Marian M. , Meng Qingrui , Hageman Lindsey , Landier Wendy , Balas Nora , Ross Elizabeth , Francisco Liton , Bosworth Alysia , Te Hok Sreng , Wong F. Lennie , Bhatia Ravi , Forman Stephen J. , Armenian Saro H. , Weisdorf Daniel J. , Bhatia Smita 
Published: October 2023

AbstractBackgroundBlood or marrow transplantation (BMT) survivors carry a high burden of morbidity, yet health care utilization by this vulnerable population remains understudied. Patterns and predictors of various domains of health care utilization in long‐term BMT survivors were evaluated.MethodsStudy participants were drawn from the Bone Marrow Transplant Survivor Study (BMTSS). Patients transplanted between 1974 and 2014 at one of three transplant centers who had survived ≥2 years after BMT and were aged ≥18 years at the time of the study were included. A BMTSS survey served as the source of data for health care utilization, sociodemographics, and chronic health conditions. Domains of health care utilization in the 2 years preceding study participation included routine checkups, BMT‐related visits, transplant/cancer center visits, emergency room (ER) visits, hospitalizations, and high health care utilization (≥7 physician visits during the 2 years before the study). Clinical characteristics and therapeutic exposures were abstracted from medical records.ResultsIn this cohort of 3342 BMT survivors (52% allogeneic), the prevalence of health care utilization declined over time since BMT for both allogeneic and autologous BMT survivors, such that among those who had survived ≥20 years, only 49%–53% had undergone routine checkups, 37%–38% reported BMT‐related visits, and 28%–29% reported transplant/cancer center visits. The presence of severe/life‐threatening conditions and chronic graft‐vs‐host disease increased the odds of health care utilization across all domains. Lower education, lack of insurance, and Hispanic ethnicity were associated with a lower prevalence of routine checkups and/or transplant/cancer center visits. Lower income increased the odds of ER visits but reduced the odds of hospitalizations or high health care utilization.ConclusionsThis study identified vulnerable populations of long‐term BMT survivors who would benefit from specialized risk‐based anticipatory care to reduce high health care utilization, ER visits, and hospitalizations.
Phenotypic plasticity and genetic trends in the past 30 years of sugarcane genetic improvement in Louisiana
Authors: Baptistella João L. Corte , Blanchard Brayden A. , Taylor Zachary , Kimbeng Collins A. , Fritsche‐Neto Roberto , Gravois Kenneth A. , Reis André F. B. 
Published: October 2023

AbstractSugar yield, which results from the combination of stalk biomass (SB) and sugar content (SC), stands as the critical trait for sugarcane breeding programs in Louisiana. Nevertheless, it remains uncertain how SB and SC have individually contributed to the recent increase in sugar yield and how the environment governs their relationship. We applied linear mixed models and the Finlay–Wilkinson model to analyze historical data from the Louisiana outfield variety trials, from plant cane to the third ratoon in multiple environments. The primary objectives were to determine (i) SC and SB genetic gain, (ii) the nature of the relationship between SB and SC, and (iii) whether genotypes are widely or specifically adapted to the environment. Our results showed that the breeding increased sugar yield by relying mostly on SB (0.600–0.652 Mg ha−1 year−1 and 0.893%–0.950% per year) and less on SC (0.371–0.384 kg year−1 and 0.282%–0.292% per year). This was achieved by increasing genotypes SB sensitivity to environmental conditions (0.310% per year) on the plant cane rather than ratoon (nonsignificant). Additionally, the environment strongly controlled the relationship between SB and SC without a significant positive or negative trend on the population mean. From an environmental perspective, high‐yielding environments also provided conditions for high SC on plant cane. Our study highlights that environment characterization is fundamental to sugarcane breeding and emphasizes the opportunity to direct efforts on selecting genotypes that are responsive to the environmental quality by producing superior SB in the ratoon crop cycles.
The influence of state ownership on environmental proactivity: An institutional perspective of international firms
Authors: Bueno‐García Manuel , Ahmadova Gozal 
Published: October 2023

AbstractThe influence of state ownership on a firm's environmental strategy is still unclear due to the varied relationships across different international institutional contexts in the firm's home and host country. Applying mixed effect regression models to a sample of 2997 observations of 298 firms from the MSCI World Index for the period 2007–2018, this paper analyzes the different effects of key institutional factors on this relationship. While a state‐owned firm from a state with a high home country environmental profile will have a more positive effect on a firm's environmental proactivity, internationalization will weaken it, since the firm will encounter higher complexity when translating its green actions into a more global institutional context. In addition, when internationalization involves a very different host country environmental profile, the greater institutional distance seems to modify the influence of state ownership on environmental proactivity. Our results provide key theoretical and practical implications for managers in relation to state‐owned firms' global environmental strategies.
Early CRP kinetics to predict long‐term efficacy of first‐line immune‐checkpoint inhibition combination therapies in metastatic renal cell carcinoma: an updated multicentre real‐world experience applying different CRP kinetics definitions
Authors: Hoeh Benedikt , Garcia Cristina Cano , Banek Severine , Klümper Niklas , Cox Alexander , Ellinger Jörg , Schmucker Philipp , Hahn Oliver , Mattigk Angelika , Zengerling Friedemann , Becker Philippe , Erdmann Kati , Buerk Bjoern Thorben , Flegar Luka , Huber Johannes , Kalogirou Charis , Zeuschner Philip 
Published: October 2023

AbstractObjectivesAlthough biomarkers predicting therapy response in first‐line metastatic renal carcinoma (mRCC) therapy remain to be defined, C‐reactive protein (CRP) kinetics have recently been associated with immunotherapy (IO) response. Here, we aimed to assess the predictive and prognostic power of two contemporary CRP kinetics definitions in a large, real‐world first‐line mRCC cohort.MethodsMetastatic renal carcinoma patients treated with IO‐based first‐line therapy within 5 years were retrospectively included in this multicentre study. According to Fukuda et al., patients were defined as ‘CRP flare‐responder’, ‘CRP responder’ and ‘non‐CRP responder’; according to Ishihara et al., patients were defined as ‘normal’, ‘normalised’ and ‘non‐normalised’ based on their early CRP kinetics. Patient and tumor characteristics were compared, and treatment outcome was measured by overall (OS) and progression‐free survival (PFS), including multivariable Cox regression analyses.ResultsOut of 316 mRCC patients, 227 (72%) were assigned to CRP groups according to Fukuda. Both CRP flare‐ (HR [Hazard ratio]: 0.59) and CRP responders (HR: 0.52) had a longer PFS, but not OS, than non‐CRP responders. According to Ishihara, 276 (87%) patients were assigned to the respective groups, and both normal and normalised patients had a significantly longer PFS and OS, compared with non‐normalised group.ConclusionDifferent early CRP kinetics may predict therapy response in first‐line mRCC therapy in a large real‐world cohort. However, further research regarding the optimal timing and frequency of measurement is needed.
Hypotension in heart failure is less harmful if associated with high or increasing doses of heart failure medication: Insights from the Swedish Heart Failure Registry
Authors: Girerd Nicolas , Coiro Stefano , Benson Lina , Savarese Gianluigi , Dahlström Ulf , Rossignol Patrick , Lund Lars H. 
Published: October 2023

AimsHeart failure (HF) medication may reduce blood pressure (BP). Low BP is associated with worse outcomes but how this association is modified by HF medication has not been studied. We evaluated the association between BP and outcomes according to HF medication dose in HF with reduced ejection fraction (HFrEF).Methods and resultsWe studied HFrEF patients from the Swedish HF registry (2000–2018). Associations between systolic BP (SBP) and cardiovascular death (CVD) and/or HF hospitalization (HFH) were analysed according to doses of renin–angiotensin system (RAS) inhibitors, beta‐blockers and mineralocorticoid receptor antagonists (MRA). Among 42 040 patients (median age 74.0), lower baseline SBP was associated with higher risk of CVD/HFH (adjusted hazard ratio [HR] per 10 mmHg higher SBP: 0.92, 95% confidence interval [CI] 0.92–0.93), which was less high risk under optimized RAS inhibitor and beta‐blocker doses (10% decrease in event rates per 10 mmHg SBP increase in untreated patients vs. 7% decrease in patients at maximum dose, both adjusted p < 0.02). Among the 13 761 patients with repeated measurements, 9.9% reported a SBP decrease >10 mmHg when HF medication doses were increased, whereas 24.6% reported a SBP decrease >10 mmHg with stable/decreasing doses. Decreasing SBP was associated with higher risk of CVD/HFH in patients with stable (HR 1.10, 95% CI 1.04–1.17) or decreasing (HR 1.29, 95% CI 1.18–1.42) HF medication dose but not in patients with an increase in doses (HR 0.94, 95% CI 0.86–1.02).ConclusionsThe association of lower SBP with higher risk of CVD/HFH is attenuated in patients with optimized HF medication. These results suggest that low or declining SBP should not limit HF medication optimization.
Nonlinear electrophoresis of nonspherical particles in a rectangular microchannel
Authors: Bentor Joseph , Xuan Xiangchun 
Published: October 2023

AbstractNonlinear electrophoresis offers advantageous prospects in microfluidic manipulation of particles over linear electrophoresis. Existing theories established for this phenomenon are entirely based on spherical particle models, some of which have been experimentally verified. However, there is no knowledge on if and how the particle shape may affect the nonlinear electrophoretic behavior. This work presents an experimental study of the nonlinear electrophoretic velocities of rigid peanut‐ and pear‐shaped particles in a rectangular microchannel, which are compared with rigid spherical particles of similar diameter and surface charge in terms of the particle slenderness. We observe a decrease in the nonlinear electrophoretic mobility, whereas an increase in the nonlinear index of electric field when the particle slenderness increases from the peanut‐ to pear‐shaped and spherical particles. The values of the nonlinear index for the nonspherical particles are, however, still within the theoretically predicted range for spherical particles. We also observe an enhanced nonlinear electrophoretic behavior in a lower concentration buffer solution regardless of the particle shape.
A new device for online nanoscale sampling and capillary electrophoresis analysis of plant sap composition
Authors: Melicherová Natália , Gloser Vít , Skalák Jan , Trtílek Martin , Lavická Jana , Foret František 
Published: October 2023

AbstractIn this work, an online sampling of plant xylem sap combined with an efficient (CE)‐based method was developed and applied to study the kinetics of changes in the sap composition and to assess plant fitness under stress conditions comprehensively. A laboratory‐built CE device was developed to provide online sampling and CE analysis of various ionogenic species in the sap during plant stress response. The rapid online sampling and short CE analysis time allow for real‐time monitoring of changes in sap constituents in the living plant during the stress response. The developed device was successfully used to analyze chloride, nitrate, and sulfate ions in the plant xylem during the salt stress or stress caused by nitrate deficiency within short time scales.