bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of assistive technology and home modifications on falls in community-dwelling older adults: a systematic review protocol
Authors: Crosby Kathryn M. , Rodriguez Catarina A. , Canas Matthew A. , Kim Changki , Noroozi Shamim , Vis-Dunbar Mathew , Komisar Vicki , Sakakibara Brodie M. , Jakobi Jennifer M. 
Published: November 2023

Abstract
Background
Fall-related injuries can reduce older adults’ independence and result in economic burdens. The assistive technologies and home modifications explored in this review are suggested to reduce the risk of falls of community-dwelling older people. However, the location of the in-home assistive technology being used, and the in-home modification likely interact and influence fall reduction and injury prevention of community-dwelling older adults. This interactive effect is poorly understood. A better understanding of the impact of assistive technologies and modifications in the homes of older adults is needed to support the appropriate application of these devices.

Objective
The objective of this systematic review is to detail the contribution of assistive technology and home modification on falls, fall frequency, fall severity, and fall location within the homes of community-dwelling older adults.

Methods
We will source articles from 3 databases (MEDLINE, CINAHL, Web of Science Core Collection) and will assess them using a set of pre-defined inclusion and exclusion criteria. Reporting will be in accordance with PRISMA 2020. Two independent reviewers will screen each study at the title and abstract and full-text level. We are managing citations within the Covidence software. Data extraction and analysis will be reported in a systematic review.

Discussion
The outcome variables of interest are fall frequency, fall location, injury, mortality, and hospitalization. These variables of interest all relate to falls, their severity, and their locations in the home. We are seeking a better understanding of how these outcomes vary with the use of different assistive technologies and home modifications as reported in the literature. This will help us understand where falls occur which may inform how different assistive technologies can be used by community-dwelling older adults to prevent falls and adverse outcomes in different areas of their homes. Our review will provide a basis for more intentional prescription of ambulatory assistive technologies and evidence-based recommendations of home modifications. It may also inform adaptations to existing technologies to foster safer mobility in the homes of community-dwelling older adults.

Systematic review registration
This protocol has been submitted for registration in PROSPERO CRD42022370172 on October 24, 2022.
Effectiveness of single-session therapy for adult common mental disorders: a systematic review
Authors: Kim Jongtae , Ryu Namgil , Chibanda Dixon 
Published: November 2023

Abstract
Background
Common mental disorders (CMDs) impose significant socioeconomic impacts on the global community. Nevertheless, over 50% of individuals with CMDs do not receive proper treatment, indicating that the current treatment modalities do not adequately tackle this issue. Since single-session therapy (SST) is a potential method for reducing the treatment gap, it is crucial to evaluate its effectiveness. Therefore, this systematic review aimed to evaluate the effectiveness of SST on CMD symptoms in adults.

Methods
This systematic review included randomised and non-randomised studies assessing the clinical effectiveness of SST on CMD symptoms in adults. English-written, peer-reviewed studies or dissertations were included, while grey literature was excluded. MEDLINE, Embase, PsycINFO, and Cochrane’s CENTRAL were searched on December 13, 2022, from their inception dates. The risk of bias in the included studies was evaluated using RoB 2 and ROBINS-I. A narrative synthesis was performed. This systematic review was registered in the PROSPERO database on July 6, 2022 (CRD42022343925).

Results
Six randomised and three non-randomised studies were included after screening 2,130 records. Three non-randomised studies with a “critical” or “serious” risk of bias were excluded from the synthesis. Therefore, six randomised trials involving 298 participants were included in the synthesis. Four out of six studies had a “high” risk of bias. The participants had non-severe symptoms at baseline, and three intervention types (behavioural activation, DBT, and solution-focused psychotherapy) were evaluated. Five of six studies showed positive results for depression, with only one reporting a positive result for anxiety.

Conclusions
SST may be effective in improving CMD symptoms in adults, particularly depression. However, there is a limit to deriving definite conclusions due to a high risk of bias in included studies, insufficient sample size and research volume. Further research exploring the characteristics of clients who can benefit from SST is required to facilitate its widespread use.
EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma
Authors: Martija Antoni Andreu , Krauß Alexandra , Bächle Natalie , Doth Laura , Christians Arne , Krunic Damir , Schneider Martin , Helm Dominic , Will Rainer , Hartmann Christian , Herold-Mende Christel , von Deimling Andreas , Pusch Stefan 
Published: November 2023

AbstractEpithelial membrane protein 3 (EMP3) is an N-glycosylated tetraspanin with a putative trafficking function. It is highly expressed in isocitrate dehydrogenase-wild-type glioblastoma (IDH-wt GBM), and its high expression correlates with poor survival. However, the exact trafficking role of EMP3 and how it promotes oncogenic signaling in GBM remain unclear. Here, we show that EMP3 promotes EGFR/CDK2 signaling by regulating the trafficking and enhancing the stability of EGFR. BioID2-based proximity labeling revealed that EMP3 interacts with endocytic proteins involved in the vesicular transport of EGFR. EMP3 knockout (KO) enhances epidermal growth factor (EGF)-induced shuttling of EGFR into RAB7 + late endosomes, thereby promoting EGFR degradation. Increased EGFR degradation is rescued by the RAB7 negative regulator and novel EMP3 interactor TBC1D5. Phosphoproteomic and transcriptomic analyses further showed that EMP3 KO converges into the inhibition of the cyclin-dependent kinase CDK2 and the repression of EGFR-dependent and cell cycle transcriptional programs. Phenotypically, EMP3 KO cells exhibit reduced proliferation rates, blunted mitogenic response to EGF, and increased sensitivity to the pan-kinase inhibitor staurosporine and the EGFR inhibitor osimertinib. Furthermore, EGFR-dependent patient-derived glioblastoma stem cells display a transcriptomic signature consistent with reduced CDK2 activity, as well as increased susceptibility to CDK2 inhibition upon EMP3 knockdown. Lastly, using TCGA data, we showed that GBM tumors with high EMP3 expression have increased total and phosphorylated EGFR levels. Collectively, our findings demonstrate a novel EMP3-dependent mechanism by which EGFR/CDK2 activity is sustained in GBM. Consequently, EMP3’s stabilizing effect provides an additional layer of tumor cell resistance against targeted kinase inhibition.
Changes in tibial cortical dimensions and density associated with long‐term locking plate fixation in goats
Authors: Bowers Kristin M. , Terrones Lori D. , Sun Xiaocun , Rifkin Rebecca , Croy Elizabeth , Adair Henry S. , Mulon Pierre‐Yves , Hecht Silke , Anderson David E. 
Published: November 2023

AbstractPurposeCortical porosis, secondary to either vascular injury or stress‐shielding, is a comorbidity of fracture fixation using compression bone plating. Locking plate constructs have unique mechanics of load transmission and lack of reliance on contact pressures for fixation stability, so secondary cortical porosis adjacent to the plate has not been widely investigated. Therefore, this study aimed to assess the effects of long‐term locking plate fixation on cortical dimensions and density in a caprine tibial segmental ostectomy model.MethodsData was acquired from a population of goats enrolled in ongoing orthopedic research which utilized locking plate fixation of 2 cm tibial diaphyseal segmental defects to evaluate bone healing over periods of 3, 6, 9, and 12 months. Quantitative data included tibial cortical width measurements and three‐dimensionally reconstructed slab density measurements, both assessed using computed tomographic examinations performed at the time of plate removal. Additional surgical and demographic variables were analyzed for effect on cortical widths and density, and all cis‐cortex measurements were compared to both the trans‐cortex and to the contralateral limbs.ResultsThe tibial cis‐cortex was significantly wider and more irregular than the trans‐cortex at the same level. This width asymmetry differed in both magnitude and direction from the contralateral limb. The bone underlying the plate was significantly less dense than the trans‐cortex, and this cortical density difference was significantly greater than that of the contralateral limb. These cortical changes were independent of both duration of fixation and degree of ostectomy bone healing.ConclusionsThis study provides evidence that cortical bone loss consistent with cortical porosity is a comorbidity of locking plate fixation in a caprine tibial ostectomy model. Further research is necessary to identify risk factors for locking‐plate‐associated bone loss and to inform clinical decisions in cases necessitating long‐term locking plate fixation.
Pharmaceutical compounding and storage of faricimab in a syringe for intravitreal injection do not impair stability and bi-specific binding properties
Authors: Jørstad Øystein Kalsnes , Foss Stian , Gjølberg Torleif Tollefsrud , Mester Simone , Nyquist-Andersen Mari , Sivertsen Magne Sand , Fossum Dag , Gleditsch Espen , Moe Morten Carstens , Andersen Jan Terje 
Published: November 2023

Abstract
Background
Intravitreal injection (IVI) of antibody biologics is a key treatment approach in ophthalmology. Pharmaceutical compounding and storage of prefilled syringes for IVI must take place without impairing the structure and function of the biologics. This study investigated the effect of withdrawing and storing the therapeutic antibody faricimab (Vabysmo, Roche, Basel, Switzerland) in the Zero Residual silicone oil-free, 0.2-mL syringe (SJJ Solutions, The Hague, the Netherlands).

Methods
To assess the effect of syringe withdrawal on faricimab, we compared samples from syringes prepared at day 0 with samples taken directly from faricimab vials. To assess the effect of syringe storage on faricimab, we kept prefilled syringes in the dark at 4 oC for 7, 14, or 37 days and compared samples from these syringes with day 0. We measured protein concentration (with spectrophotometry), stability and integrity (with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), size-exclusion chromatography (SEC), and melting temperature (Tm)), as well as binding of faricimab to its cognate antigens: vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2) (with enzyme-linked immunosorbent assay (ELISA)).

Results
Faricimab migrated in line with its expected molecular mass under both reducing and non-reducing conditions for all time points when analyzed with SDS-PAGE, without any sign of degradation products or aggregation. The SEC elution profiles were identical for all time points. There were slight variations in Tm for different time points compared to day 0 but without consistent relationship with storage time. ELISA did not detect differences in VEGF-A or Ang-2 binding between time points, and faricimab did not bind the neonatal Fc receptor.

Conclusions
Withdrawal and storage of faricimab in syringes for up to day 37 did not impair the structure and bi-specific binding properties of the therapeutic antibody.
Bilateral multiple stroke, left upper extremity ischemia, and transient complete atrioventricular block in transcatheter aortic valve implantation: a case report
Authors: Mitsuta Yuki , Nakamura Shingo , Uemura Yumiko , Tashima Koichiro , Oyoshi Takafumi , Hirata Naoyuki 
Published: November 2023

Abstract
Background
Transcatheter aortic valve implantation (TAVI) is a minimally invasive surgery. However, there is a risk of surgical manipulation causing detachment of a lesion of the aortic valve, which can result in various embolisms.

Case presentation
An 87-year-old woman with symptomatic severe aortic valve stenosis was scheduled for transfemoral TAVI under monitored anesthesia. Preoperative examination revealed severe calcification of the aortic valve, but there was no calcification in the ascending aorta. After a delivery catheter system passed the aortic valve, left radial arterial pressure dropped significantly, and complete atrioventricular block (CAVB) occurred. Catecholamine administration and ventricular pacing improved hemodynamics, and a self-expandable valve was implanted. CAVB resolved after surgery, but her state of consciousness was poor, and her left hand became ischemic. Imaging studies revealed multiple embolic infarcts in her bilateral cerebrum and cerebellum.

Conclusions
It should be noted that there is a risk of detachment of a calcified lesion of the aortic valve during TAVI, which can cause embolisms not only in the brain but also in the extremities and coronary arteries.
The mediating role of FoMO and the moderating role of narcissism in the impact of social exclusion on compulsive buying: a cross-cultural study
Authors: Mert Merve , Tengilimoğlu Dilaver 
Published: November 2023

Abstract
Background
There is an interrelationship between the concepts of social exclusion, compulsive buying behavior, fear of missing out (FoMO), and narcissism. Nevertheless, the extent to which these concepts mediate or moderate their relationships with each other has not been efficiently investigated.

Objective
This research aims to investigate how FoMO mediates and narcissism moderates the correlation between social exclusion and compulsive buying behavior. In addition, the research aims to test a conceptual model and highlight the differences that may occur in the conceptual model proposed in two different countries.

Methods
This model was analyzed among 1007 university students (Turkey = 506, Denmark = 501). The study used scales to measure social exclusion, compulsive buying behavior, FoMO, and narcissism. The study employed PROCESS Model 4 to analyze direct and indirect (mediation) effects and PROCESS Model 59 to assess conditional (moderation) effects. Furthermore, the Johnson-Neyman technique was utilized to investigate interaction terms.

Results
The findings indicate that those who face social exclusion tend to participate more in compulsive buying, and this connection is partly explained by FoMO. This suggests that individuals who encounter social exclusion may have an increased likelihood of experiencing FoMO, which may subsequently contribute to compulsive buying behavior. Furthermore, the moderating effect of narcissism differed between the Turkey and Danish samples. Specifically, in the Turkey sample, narcissism only modified the connection between social exclusion and FoMO, while in the Danish sample, it impacted both the connection between social exclusion and FoMO and the connection between FoMO and compulsive buying.

Conclusion
The obtained results show that the regulating role of narcissism is different in Turkey and Denmark within the conceptual model we studied.
Thermal ablation with configurable shapes: a comprehensive, automated model for bespoke tumor treatment
Authors: Paolucci Iwan , Bulatović Milica , Weber Stefan , Tinguely Pascale 
Published: November 2023

Abstract
Background
Malignant tumors routinely present with irregular shapes and complex configurations. The lack of customization to individual tumor shapes and standardization of procedures limits the success and application of thermal ablation.

Methods
We introduced an automated treatment model consisting of (i) trajectory and ablation profile planning, (ii) ablation probe insertion, (iii) dynamic energy delivery (including robotically driven control of the energy source power and location over time, according to a treatment plan bespoke to the tumor shape), and (iv) quantitative ablation margin verification. We used a microwave ablation system and a liver phantom (acrylamide polymer with a thermochromic ink) to mimic coagulation and measure the ablation volume. We estimated the ablation width as a function of power and velocity following a probabilistic model. Four representative shapes of liver tumors < 5 cm were selected from two publicly available databases. The ablated specimens were cut along the ablation probe axis and photographed. The shape of the ablated volume was extracted using a color-based segmentation method.

Results
The uncertainty (standard deviation) of the ablation width increased with increasing power by ± 0.03 mm (95% credible interval [0.02, 0.043]) per watt increase in power and by ± 0.85 mm (95% credible interval [0, 2.5]) per mm/s increase in velocity. Continuous ablation along a straight-line trajectory resulted in elongated rotationally symmetric ablation shapes. Simultaneous regulation of the power and/or translation velocity allowed to modulate the ablation width at specific locations.

Conclusions
This study offers the proof-of-principle of the dynamic energy delivery system using ablation shapes from clinical cases of malignant liver tumors.

Relevance statement
The proposed automated treatment model could favor the customization and standardization of thermal ablation for complex tumor shapes.

Key points
• Current thermal ablation systems are limited to ellipsoidal or spherical shapes.
• Dynamic energy delivery produces elongated rotationally symmetric ablation shapes with varying widths.
• For complex tumor shapes, multiple customized ablation shapes could be combined.

Graphical Abstract
Deep learning performance for detection and classification of microcalcifications on mammography
Authors: Pesapane Filippo , Trentin Chiara , Ferrari Federica , Signorelli Giulia , Tantrige Priyan , Montesano Marta , Cicala Crispino , Virgoli Roberto , D’Acquisto Silvia , Nicosia Luca , Origgi Daniela , Cassano Enrico 
Published: November 2023

Abstract
Background
Breast cancer screening through mammography is crucial for early detection, yet the demand for mammography services surpasses the capacity of radiologists. Artificial intelligence (AI) can assist in evaluating microcalcifications on mammography. We developed and tested an AI model for localizing and characterizing microcalcifications.

Methods
Three expert radiologists annotated a dataset of mammograms using histology-based ground truth. The dataset was partitioned for training, validation, and testing. Three neural networks (AlexNet, ResNet18, and ResNet34) were trained and evaluated using specific metrics including receiver operating characteristics area under the curve (AUC), sensitivity, and specificity. The reported metrics were computed on the test set (10% of the whole dataset).

Results
The dataset included 1,000 patients aged 21–73 years and 1,986 mammograms (180 density A, 220 density B, 380 density C, and 220 density D), with 389 malignant and 611 benign groups of microcalcifications. AlexNet achieved the best performance with 0.98 sensitivity, 0.89 specificity of, and 0.98 AUC for microcalcifications detection and 0.85 sensitivity, 0.89 specificity, and 0.94 AUC of for microcalcifications classification. For microcalcifications detection, ResNet18 and ResNet34 achieved 0.96 and 0.97 sensitivity, 0.91 and 0.90 specificity and 0.98 and 0.98 AUC, retrospectively. For microcalcifications classification, ResNet18 and ResNet34 exhibited 0.75 and 0.84 sensitivity, 0.85 and 0.84 specificity, and 0.88 and 0.92 AUC, respectively.

Conclusions
The developed AI models accurately detect and characterize microcalcifications on mammography.

Relevance statement
AI-based systems have the potential to assist radiologists in interpreting microcalcifications on mammograms. The study highlights the importance of developing reliable deep learning models possibly applied to breast cancer screening.

Key points
• A novel AI tool was developed and tested to aid radiologists in the interpretation of mammography by accurately detecting and characterizing microcalcifications.
• Three neural networks (AlexNet, ResNet18, and ResNet34) were trained, validated, and tested using an annotated dataset of 1,000 patients and 1,986 mammograms.
• The AI tool demonstrated high accuracy in detecting/localizing and characterizing microcalcifications on mammography, highlighting the potential of AI-based systems to assist radiologists in the interpretation of mammograms.

Graphical Abstract
Rare cause of bilateral basal ganglia calcifications: hemispheric AVM
Authors: Gozgec Elif , Ogul Hayri 
Published: November 2023

Abstract
Background
Intracranial calcifications may occur physiologically or pathologically for many reasons. In arteriovenous malformations (AVMs), calcification is not uncommon and is usually detected in the lesion vessel walls and surrounding parenchyma. However, rarely calcifications can also be seen in bilateral basal ganglia and especially in watershed areas, which are far from the lesion.

Case presentation
In this article, we present a 47-year-old case of hemispheric AVM accompanied by bilateral basal ganglia calcification.

Conclusions
Since the direct diagnosis of AVM in non-contrast brain-computed tomography (CT) is difficult, the detection of calcification in these regions requires the presence of AVM in the differential diagnosis.
Apolipoprotein D concentration in Parkinson’s disease patients
Authors: Shaheen Hala A. , Sobhy Sayed , El Mously Sherine , Eid Mohammed Mansour Abbas , Omirah Marwa Hanafy Abo , Abbas Asmaa , Gomaa Mohammed 
Published: November 2023

Abstract
Background
Parkinson’s disease (PD) is distinguished recently by an increase in inflammation and oxidative stress. Apolipoprotein D (Apo D) is a neuroprotective protein that was discovered to be increased in PD-affected brains. The aim of our study was to measure the ApoD serum level in individuals with PD and to correlate it with the clinical data of those individuals. Thirty individuals suffering from idiopathic PD were subjected to neurological examination, disease intensity by applying the Unified Parkinson’s Disease Rating Scale (UPDRS) and measurement of Apo D blood levels. Thirty age and sex matched controls were included for comparison of Apo D concentration.

Results
Apolipoprotein D levels were substantially greater in PD individuals than in controls. The correlation between Apo D serum level and PD severity determined by the UPDRS and its subscales was positive.

Conclusion
PD patients had increased blood level concentration of Apo D, which was associated positively with disease intensity. We suggest that Apo D serum level can be used as a predictor factor for PD severity. More studies are warranted to study how to target the Apo D in PD patients and thus helping to reduce the oxidative stress and inflammatory cascade involved in the pathogenesis of the disease.