bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping seasonal human mobility across Africa using mobile phone location history and geospatial data
Authors: Voepel Hal E. , Lai Shengjie , Steele Jessica , Cunningham Alexander , Rogers Grant , Ruktanonchai Corrine , Ruktanonchai Nick , Utazi C , Sorichetta Alessandro , Tatem Andrew 
Published: January 2025

Abstract

Seasonal human mobility data are essential for understanding socioeconomic and environmental dynamics, yet much of Africa lacks comprehensive mobility datasets. Human movement, shaped by economic needs, family responsibilities, seasonal climatic variations, and displacements, is poorly documented in many regions due to limitations of traditional methods like censuses and surveys. This study addresses these gaps by leveraging the Google Aggregated Mobility Research Dataset (GAMRD) and a Bayesian spatiotemporal framework to estimate pre-pandemic monthly mobility flows at both national and regional scales across Africa for 2018–2019. We analysed 25 countries with complete GAMRD data and developed regional models to estimate mobility in 28 additional countries with sparse or missing records, filling critical data gaps. Key predictors, including GDP per capita, underweight children, infant mortality, environmental variables like stream runoff and evapotranspiration, and covariate interactions, revealed the complexity of mobility drivers. This approach provides robust estimates of seasonal mobility changes in data-limited areas, and offers a foundational understanding of African mobility dynamics, which highlights the value of innovative modelling and novel sources to bridge data gaps for supporting regional planning and policy-making.
Spatio-temporal evolution of supply-demand-support system coupling coordination and its influencing factors of Chinese cultural tourism
Authors: Zhang Hang , Chen xingpeng , PU lili 
Published: January 2025

Abstract

In recent years, the transformation and upgrading of cultural tourism, and the development of quality and efficiency improvement have become hot topics of concern and academic discussion in China's economic and social circles. Based on the coupling coordination theory, this study constructs a coupling coordination model of product supply and economic development of cultural tourism, calculates the coupling coordination level of 31 provinces (autonomous regions and municipalities) in China from 2010 to 2020, divides the specific development stages and types according to the calculated results, and then analyzes the spatiotemporal evolution of the coupling coordination level, and then analyzes its influencing factors according to the GTWR model. The results are as follows: (1) From 2010 to 2020, the global spatial positive correlation between the coupling and coordinated development ability of cultural tourism supply-demand-support system is prominent, the dynamics of local space is strong, and the cooperation ability shows the characteristics of strong east and weak west. (2) The ability of coupling and coordinated development decreases from east to west, but the development advantage of southwest China is obvious, among which the self-activity degree of northwest region is low, while southwest region is the highest. Central China has the highest degree of spatial dependence, while South China has the lowest. The southwest region is the traditional advantageous region of China's cultural tourism development, and maintains a relatively stable development trend, while the cultural tourism in the northeast region has weakened. (3) The degree of openness has a large trend of influencing ability, while the development of other five influencing factors, such as scientific and technological development, maintains a relatively stable ability. In the stage of imbalanced development, the influence of openness, scientific and technological support, and potential consumption has decreased, while the influence of the influencing factors of household consumption and industrial support has remained unchanged, and the influence of economic security has increased. The influencing ability of six influencing factors, such as the degree of openness in the transitional development stage, remained unchanged. The influencing ability of the degree of openness in the coordinated development stage decreased, while the influencing ability of five influencing factors, such as scientific and technological support, maintained the characteristics of stable growth, and the self-development ability continued to increase. Recognize and explore cultural tourism as a "community", put forward specific countermeasures and suggestions, and realize the sustainable and healthy development of cultural tourism product supply and economic development.
The Capability of Health Facilities to Manage Noncommunicable Diseases in Uganda
Authors: Robert  
Published: January 2025

Abstract

With funding from the Danish Civil Society Fund (CISU) and supported by the Danish NCD Alliance (DNCDA) and Uganda Non-Communicable Diseases Alliance (UNDCA), the study focused on assessing the capacity of lower-level health centers (HC III & HC IV) to manage noncommunicable diseases (NCDs) in Uganda. Specifically, the survey assessed the capacity of the HC III and HC IV units to (i) detect the main NCDs (cancer, diabetes and heart disease); (ii) offer clinical care, including timely referral of patients with NCDs; and (iii) raise awareness, through health education and health promotion, of major risk factors for NCDs. The survey focused mainly on cancer, diabetes and heart disease as the most prevalent NCDs. Using a cross-sectional survey design that included both qualitative and quantitative methods, the study revealed that HCs III and IV had inadequate technology, medicine, facilities, policies, recordkeeping, and human resource capacity to manage NCDs and conduct effective health education and promotion. As such, the study recommended that the staffing norms of all levels of HCs be upgraded, funding be increased at the district level, the salaries and general working conditions of HC workers be improved, and all HC health personnel be trained in NCD management.
Prediction and validation of aeroelastic limit cycle oscillations using harmonic balance methods and Koopman operator
Authors: McGurk Michael , Yuan Jie 
Published: January 2025

Abstract

The presence of nonlinearities within aerospace systems often triggers self-sustaining oscillations known as Limit Cycle Oscillations (LCO), demanding costly analysis for identification, notably through the resource-intensive generation of bifurcation diagrams. Consequently, the expense incurred tends to sideline nonlinear analysis in initial design phases, constraining design possibilities and impeding data-driven methods for nonlinear aeroelastic analysis reliant on efficient data collection, which has garnered attention in the aerospace sector. This work proposes a computationally efficient numerical framework for calculating LCO amplitudes and determining stability in nonlinear aeroelastic systems. The framework consists of using Harmonic Balance Methods (HBM) combined with the Hill method for the stability analysis. To avoid the sorting problem, the Koopman operator-based data-driven method is implemented. The methodology is applied to numerical test cases, encompassing both smooth and nonsmooth nonlinearities, and validated against outcomes from MATCONT and COCO. Subsequently, an experimental validation of the framework is conducted, comparing its outcomes to existing LCO experimental data acquired through control-based continuation experiments.
Clinical outcomes of radioactive 125 I seed brachytherapy for recurrent refractory differentiated thyroid cancers
Authors: Gao Zhen , Li Yixing , Dai Jinzhao , Di Xuemin , Liu Zezhou , Yu Huimin , Liu Xiaoli , Wang Juan , Zhang Hongtao 
Published: January 2025

Abstract

[Objective:]The purpose of this research was to evaluate the feasibility and efficacy of 125I seed brachytherapy for recurrent refractory differentiated thyroid cancers.
[Methods]:Between August 2005 and March 2023 33 patients with recurrence refractory of
differentiated thyroid cancer were treated with 125I seed brachytherapy. 125I seeds were implanted into the tumor under the guidance of CT and/or 3D-printed template images with the median prescription dose of 126 Gy (range, 90-155 Gy). The median seed number was 54 (range 8-214). Clinical efficacy was evaluated with Response Evaluation Criteria in Solid Tumors. Follow-up
Survival and adverse events were analyzed.
[Results:]125I seeds were successfully implanted in 44 lesions among 33 patients. Lesions included 34 cervical lymph node metastases, 2 cases of recurrent thyroid lesions, 2 cases of pulmonary metastases, 3 cases of bone metastases,1 cases of pleural metastases, 1 case of mediastinal lymph node involvement, and 1 case of back soft tissue metastasis. Patients were monitored for 6–96 months. Six months postoperatively, CT images revealed 26 cases of CR, 14 cases of PR, and 4 cases of Stable Disease (SD). The ORR was 90.9% (40/44), and the LCR reached 100% (44/44) at 6 months. The median OS was 40.7 months, with 1-year,2-year,3-year, 4-year and 5-year survival rates of 91%, 88%, 74%,64.5%,and 51%, respectively.14 patients had died due to systemic metastases.No severe complications occurred.
[Conclusions:]CT-guided iodine-125 brachytherapy provided a safe and effective choice for recurrent refractory differentiated thyroid cancers with significant local therapeutic effects and minor complications.
Artificial Intelligence (AI) and Liquid Biopsy Transforming Early Detection of Liver Metastases in Gastrointestinal Cancers
Authors: P. Thilagesh , S. Anand Kumar , U. Aiswarya Nair , S. Rabiniraj , P. Shobana , M. Subramani , K. Sriram 
Published: January 2025

Abstract:
Liver metastases from Gastrointestinal (GI) cancers present significant challenges in oncology, often signaling poor prognosis. Traditional detection methods like imaging and tissue biopsies have limitations in sensitivity, specificity, and tumor heterogeneity represen-tation. The advent of artificial intelligence (AI) in healthcare, driven by advancements in ma-chine learning, algorithms, and data science, offers a promising frontier for early detection and management of liver metastases. This review explores the integration of AI and liquid biopsy technologies as transformative tools in the proactive detection of liver metastases aris-ing from GI malignancies.
Liquid biopsy, a non-invasive method, analyzes circulating tumor cells (CTCs), cell-free DNA (cfDNA), and circulating tumor DNA (ctDNA) in bodily fluids. It provides a compre-hensive overview of tumor heterogeneity and enables real-time monitoring of tumor evolu-tion and treatment response. Despite its advantages, liquid biopsy faces challenges such as low sensitivity for early-stage metastases, reduced detectability due to liver filtration, and technical limitations.
AI enhances the potential of liquid biopsies by improving diagnostic accuracy through ad-vanced algorithms like Convolutional Neural Networks (CNNs) and Natural Language Pro-cessing (NLP). These AI models analyze complex biomedical data, offering higher sensitivity and specificity in cancer detection. The synergy between AI and liquid biopsies promises early detection, better disease monitoring, and personalized treatment strategies.
This review underscores the significant advancements AI and liquid biopsy technologies bring to oncological precision medicine, particularly in improving overall survival (OS) and disease-free survival (DFS) for patients with GI cancer metastases. As we transition into the era of precision medicine, the integration of these technologies holds the potential to redefine cancer care and patient management.
Efficacy and Safety of Immunotherapy Combined with Anlotinib as FirstLine Treatment in Older NSCLC Patients with PD-L1
Expression<50%
Authors: Li Xiangyu , Wang Wei , Xu Chunhua , Yuan Qi 
Published: January 2025

Background:
Non-small cell lung cancer (NSCLC) predominantly affects older
adults; these patients have significant comorbidities, making them unsuitable for chemotherapy. This study aimed to evaluate the efficacy and safety of immune checkpoint inhibitor (ICI) along with anlotinib combination therapy as a first-line treatment in older
NSCLC patients with programmed death ligand-1(PD-L1) expression＜50%.

Methods:
We conducted a retrospective observational study including 73 patients with advanced NSCLC treated at Nanjing Brain Hospital. All patients were aged 75 years or older
and received first-line systemic therapy with a combination of PD-1 inhibitors and anlotinib. Clinical data were obtained from electronic medical records and analyzed through
Kaplan-Meier estimates and Cox proportional hazards models to assess progression-free
survival (PFS), overall survival (OS), and the influence of different variables.

Results:
The patients had a median age of 80 years. The median PFS was 9.8 months
(95% CI: 7.9-11.7), and the median OS was 19.5 months (95% CI: 17.3-21.7). PD-L1 tumor proportion score (TPS) <1% (χ2=10.263, P=0.001) and absence of treatment-induced
hypertension (χ2=12.804, P<0.001) were identified as independent risk factors for poor
PFS. Advanced disease stage (χ2=11.900, P=0.001), PD-L1 TPS <1% (χ2=6.643,
P=0.010), and having two or more chronic comorbidities (χ2=9.011, P=0.003) were independent risk factors for poor OS. Treatment-related
hypertension was observed in 25% of
patients and was associated with better PFS.

Conclusion:
ICI-anlotinib combination therapy showed promising efficacy and an acceptable safety profile in older NSCLC patients. Future studies involving
larger populations are necessary to validate these findings and determine the potential of PD-L1 levels
as a biomarker for treatment stratification.
Osseointegration Process Improving via Functionalization of Titanium Dioxide Nanotubes: A Bibliometric Analysis and Systematic Review
Authors: da Silva Braga Martins Junior Sergio Murilo , Noguera Bazan Jose Manuel , dos Santos Silva Lucas , Nascimento da Silva Luis Claudio 
Published: January 2025

Introduction/Objectives:
Failures of osseointegrated implants pose a significant challenge
in the medical field, often attributed to prolonged osseointegration periods and bacterial infections.
Functionalization of Titanium Dioxide Nanotubes (TNTs) has emerged as a promising
strategy to improve osseointegration and mitigate infections. This study aims to conduct a bibliometric
analysis and systematic review to identify trends, gaps, and advancements in research on the
functionalization of TNTs for osseointegration improvement.

Methods:
Articles were retrieved from the Web of Science database using the keywords "osseointegration,"
"titanium dioxide nanotubes," and "functionalization." The inclusion criteria were studies
published between 2014 and 2023, written in English, and focusing on the use of TNTs in implant
surface modifications. A total of 126 articles were included after screening. Data extraction
and analysis were performed using VOS Viewer, Microsoft Excel, and GraphPad Prism.

Results:
The review revealed a growing number of publications on TNT functionalization, with
China, the United States, and Brazil leading in contributions. Key findings include the effectiveness
of TNTs loaded with bioactive agents (e.g., silver, strontium, hydroxyapatite) in promoting osseointegration
and antibacterial activity. Collaborative networks among institutions and authors were
mapped, highlighting the Sao Paulo State University and Yong Huang as the most prolific contributors.

Conclusion:
The findings underscore the potential of TNT functionalization to enhance implant
performance. However, a gap remains in translating preclinical findings into clinical trials. Future
research should focus on clinical validation to bridge this gap and translate laboratory advancements
into therapeutic solutions.
Advances in the Study of Halogenated Natural Products
Authors: Zhang Lijing , Liu Bing , Zhu Ting , Tian Xue , Chen Ning , Wang Yuxin 
Published: January 2025

Abstract:
Halogenated natural products are an important class of secondary metabolites that are
widely distributed in nature. The presence of halogen atoms usually enhances the pharmacological
activity of the compounds. As a result, halogenated natural products have shown promising pharmacological
activities in antibacterial, antitumour, anti-inflammatory and antiplasmodial properties,
providing a rich resource for the development of new drugs. To date, more than 62% of halogenated
compounds are produced by marine organisms, mainly including marine sponges, algae, corals,
fungi and other organisms. In addition, terrestrial microorganisms, including bacteria and fungi,
also produce halogenated metabolites, which are equally important sources of halogenated natural
products. The biosynthesis of halogenated natural products involves the synergistic action of multiple
enzymes that efficiently and selectively bind halogen atoms to organic molecules, a process that
enhances the biological activity of the compounds. Halogenated natural products have a wide range
of uses as important raw materials in the agricultural, pharmaceutical and chemical industries. This
paper reviews the progress of research on halogenated compounds and their biosynthesis in recent
years, laying the foundation for further utilisation and development of halogenated compounds.
A Novel Platform for Protein Post-translational Modifications based on a High-density Antibody Array
Authors: Wang Tao , Li Wei , Lv Jingqiao , Li Na , Zhang Peng , Tang Hao , Jiang Lei , Wang Yanlin , Mao Mike , Luo Shuhong , Dong Hua , Huang Ruo-Pan 
Published: January 2025

Background:
Post-Translational Modifications (PTMs) are covalent modifications of
amino acids added to proteins that can significantly affect proteins’ structures and functions. PTMS
are, therefore, important biomarkers due to their regulation of various bioactivities. Protein array is
a robust tool for detecting and quantifying proteins with high throughput, small sample requirement,
and high sensitivity.

Objectives:
On the basis of a high-density array, we developed a new platform to detect the PTM
level, such as phosphorylation and acetylation, and changes in larger scales using an anti-PTM antibody.

Methods:
THP-1 cells treated with phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide
(LPS) were used for testing the new system and quantifying the phosphorylation and acetylation
level change. The proteins whose phosphorylation and acetylation levels changed significantly were
screened and compared with reported phenotypic change.

Results:
By using antibodies against phosphorylation and acetylation, the PTM change for the same
protein can be detected. Based on the proteins whose PTM is significantly different before and after
treatment, it was found that the enriched pathways and biological progress agreed with the stimulation
of PMA and LPS.

Conclusion:
Our results supported the idea that this platform can be used to effectively compare the
phosphorylation and acetylation level changes among samples and screen for biomarkers on the
proteomic scale.
Current Developments in Palliative Care for Patients with Lung Cancer
Authors: Ingle Pravinkumar , Lian Wei Kian , Ting Shui Jian , Ngui Yew Ung , Chong Chiau Win , Teoh Hui Qing , Hatware Ketan 
Published: January 2025

Abstract:
Lung cancer has become one of the leading causes of death worldwide, following cardiovascular
disease. It is defined as a disease in which lung cells divide uncontrollably, forming tumors
that can either remain localised or spread to other parts of the body. Patients with lung cancer
often experience symptoms, such as shortness of breath, pain, and loss of appetite, which can
significantly impact their quality of life. Additionally, the treatment of lung cancer, particularly
chemotherapy, can cause severe adverse effects. Risk factors, such as smoking, and alcohol consumption,
can increase the likelihood of developing lung cancer. Therefore, it is essential to provide
palliative care to all lung cancer patients to manage their symptoms and improve their quality
of life. Simply relying on curative treatments, like chemotherapy and radiation therapy, may not
be enough to achieve therapeutic goals. Effective communication between healthcare professionals
and patients is crucial in ensuring that appropriate palliative care is provided. Misunderstandings
can arise if there are gaps in communication between patients and healthcare professionals,
leading to suboptimal care plans. Unfortunately, palliative care services are still not widely known
or easily accessible. More research is needed to promote and expand access to palliative care services
for patients with lung cancer. This review summarises the etiological factors, consequences,
symptoms management, and the beneficial role of palliative care in surgery, chemotherapy, and radiotherapy
for lung cancer patients. It also discusses implications for practice and research, as
well as challenges in palliative and end-of-life care for these patients.
Infection Screening and Vaccination of Adult and Pediatric Patients with
Autoimmune Inflammatory Rheumatic Diseases: An Emirati Delphi
Consensus
Authors: Almarzooqi Ahlam , Abdalla Jehad , Elsadeg Mohamed Sharif , Zamani Noura , Ginawi Amel Abdel Gadir , Alrawi Zaid , Namas Rajaie , Aldhaheri Afra , Zayat Ahmed , Elbadawi Faisal , ALDabal Layla , Aljaberi Najla , Abdullah Shazia , Hannawi Suad , Alnaqbi Khalid A. , Dhaheri Fatima Al , Hameed Beena , Al-Saleh Jamal 
Published: January 2025

Introduction:
Patients with autoimmune and inflammatory rheumatic diseases
(AIIRD) have an increased susceptibility to infections due to their compromised immune systems
and the use of immunosuppressive therapies. Infections are a leading cause of morbidity and mortality in these patients, emphasizing the need for strategies such as infection control and vaccination to prevent avoidable harm to both patients and healthcare workers. This study aims to provide expert consensus on infection screening and vaccination guidelines for AIIRD patients.

Methods:
A task force of experts from the United Arab Emirates developed a set of statements
based on available evidence and expert opinion. The consensus was structured into two main categories: infection screening (9 statements with 23 sub-statements) and vaccination (7 statements).

Results:
The infection screening consensus covered nine key areas: tuberculosis (TB) screening
(I.1), methods and periodicity of TB screening (I.2), strategies for managing positive IGRA test
results (I.3), and infection control for hepatitis B (I.4), hepatitis C (I.5), HIV (I.6), varicella-zoster
virus (I.7), and Pneumocystis jirovecii (I.8). The vaccination consensus included recommendations on general vaccination principles (V.0) and specific vaccinations for influenza (V.1), pneumococcal disease (V.2), human papillomavirus (HPV) (V.3), varicella-zoster virus (V.4), tetanus
(V.5), and COVID-19 (V.6). Delphi voting showed strong consensus among the task force experts, validating their relevance and applicability for clinicians managing AIIRD patients.

Conclusion:
This Emirati consensus provides up-to-date guidance and recommendations for clinicians to enhance the care and safety of AIIRD patients.

result:
Delphi voting revealed a very high level of agreement with the recommendations among the task force experts.