bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Characterization, and Evaluation of MCF-7 (Breast Cancer) for Schiff, Mannich Bases, and Their Complexes
Authors: Al-Khazraji Ali Abdulkareem 
Published: February 2024

A new synthesis of Schiff (K) 6 and Mannich bases (Q) 7 had formed compound (Q) 7 by reacting compound (K) with N-methylaniline at the presence of formalin 35% to given Mannich base (Q). Additionally, new complexes were formed by reacting Schiff base (K) with metal salts CuCl2·2H2O, PdCl2·2H2O, and PtCl6·6H2O by 2:1 of M:L ratio. New ligands and their complexes were characterized, exanimated, and confirmed through several techniques, including FTIR, UV-visible, 1H-NMR, 13C-NMR spectroscopy, CHN analysis, FAA, TG, molar conductivity, and magnetic susceptibility. These compounds and their complexes were screened against breast cancer cells. It was determined that several of these compounds had a significant anti-breast cancer effect due to their ability to induce cell death and reduce tumor growth. Metal complexes have been thoroughly studied as a potential anti-cancer therapy and have shown promising results. It was revealed these complexes uniquely affect the biological processes involved in cancer growth, leading to apoptosis and fading of cells. To form MCF-7 cell cultures, MCF-7 cells were seeded in 96-well plates at an appropriate density (5 × 105 cells/well). Metal complexes utilized in MCF-7 therapy have the potential to disband some of the harms associated with chemotherapy, such as drug resistance and toxicity.
DETERMINATION OF IN VITRO CYTOTOXICITY OF ENTRECTINIB AND PEMIGATINIB NANOSPONGES TABLETS ON A 498, MCF-7 AND PANC-1 CELL LINES
Authors: MAMATHA PALANATI , D. V. R. N. BHIKSHAPATHI 
Published: February 2024

Objective: The aim of this study was to improve the oral solubility of Pemigatinib and Entrectinib through incorporation into nanosponges (NSs), and further the cytotoxic potential of optimized formulations of NSs on A498, MCF-7, and PANC-1 cell lines in the MTT based Cell proliferation assay was analyzed.
Methods: In the current study Pemigatinib and Entrectinib were formulated in to NS tablets and cytotoxicity was determined by using A498, MCF-7, and PANC-1 cell lines. The optimized NS formulation was determined prepared into a tablet dosage form, which further was evaluated for physical parameters and in vitro drug release study. For cytotoxicity studies, MTT assay was conducted for these formulations, IC50 values were calculated for the tested compound and compared with 5-Fluorouracil.
Results: The optimized formulation was evaluated for physical parameters and in vitro drug release study, the results were satisfactory. The IC50 of Entrectinib NS, Pemigatinib NS and 5-Fluorouracil, against A498 cell line was 26.34, 85.24 and 15.24 µg/ml, respectively. The IC50 of Entrectinib NS, Pemigatinib NS and 5-Fluorouracil, against MCF-7 cell line was 71.54, 35.48 and 24.56 µg/ml, respectively. The IC50 of Entrectinib NS, Pemigatinib NS and 5-Fluorouracil, against PANC-1 cell line was 35.14, 22.54 and 22.54 µg/ml, respectively. It was observed that the IC50 of drug-loaded NS was higher than the comparator drug and these enter the cells by active transport and induce cytotoxicity to the cells.
Conclusion: The overall results from the studies suggest that Entrectinib NS and Pemigatinib NS provided efficient cytotoxic effects, which could play a significant role in the percentage cell death.
Female non-farm employment and family members’ dining out and nutrient intake: Evidence from China
Authors: Qu Yufei , Lu Qian , Qu Yuxuan , Li Han 
Published: February 2024

Abstract
Owing to the different roles of men and women in the family, women may affect family welfare differently than men. Existing research only analyzes the impact of non-farm employment or male non-farm employment on family welfare, and the impact of female non-farm employment on the family has not been addressed in existing studies. China is a particularly interesting case given its rapid economic development and rising rates of female non-farm employment. We used data from the China Health and Nutrition Survey to analyze the dietary patterns of family members and identify the factors that influence food choices and nutrient intake. The results showed that female non-farm employment reduced household protein and calorie intake levels and increased the frequency of dining out among rural household members.
LABOR ABSORPTION AND CONTRIBUTION OF THE PROCESSING INDUSTRY SECTOR TO ECONOMIC GROWTH IN THE PROVINCE OF THE BANGKA BELITUNG ISLAND
Authors: Wulandari Ayu , Hidayati Hidayati 
Published: February 2024

This research aims to analyze the absorption of labor and the contribution of the processing industry sector to economic growth in the Province of the Bangka Belitung Islands. The data used in this research is secondary data of time series for the period 2012 to 2021 which is sourced from the Indonesia Statistics (BPS) of the Bangka Belitung Islands Province and literature studies. The analytical method used to calculate the elasticity of employment opportunities to see the absorption of labor and the proportion method to see the contribution of economic growth this research used the proportion method. The results showed that the Manpower and Workforce Growth Rate in the processing industry sector in the Province of the Bangka Belitung Islands in 2009-2021 is fluctuated. The average distribution of workers in the processing industry sector is 6.45 percent. The highest distribution of labor in the processing industry sector occurred in 2020 was 8.19 percent and the lowest in 2010 at 4.47 percent. The absorption of labor in the processing industry sector is mostly absorbed in the tin metal processing industry. The processing industry sector is one of the five sectors that have the largest contribution to the economic structure of the Bangka Belitung Islands over the last 10 years besides agriculture sector, trade sector, mining sector, and construction sector. The average elasticity of employment opportunities in the Province of the Bangka Belitung Islands is 315.41 percent.
Green Horizons: Enhancing Customer Satisfaction through Quality Experiences, Mediated by Green Perceived Value and Green City Image in Kota Lebong Tourism, Bengkulu Province
Authors: Gandasari Arum Laila , Daulay Muhammad Yasser Iqbal 
Published: February 2024

Pupose: The objective of this research is to comprehensively analyze the relationship between experience quality and customer green satisfaction, as well as to investigate the mediating roles of green city image and green perceived value in the context of environmentally friendly tourist destinations.
Method:This study employs a quantitative-explanatory approach with the population of focus being all visitors to tourist attractions in Lebong City, Bengkulu Province. The exact size of this population cannot be determined. The total sample size for this study is 360 respondents. And analysed using SEM-PLS.
Result: The result of this study reveals experience quality influence green satisfaction, green city image, and green perceived value. Also, both green city image and green perceived value mediated the relationship between experience quality on green satisfaction.
Corporate Governance Mechanism and Capital Structure Decision: Evidence from Indonesia
Authors: Lestari Agnes , Murhadi Werner R. , Ernawati Endang 
Published: February 2024

Purpose: Decisions related to the capital structure are crucial for companies because the proportion of funding from debt and equity determines the company's value and is directly related to shareholders' welfare. This study aims to examine how corporate governance affects the capital structure.
Method: Board size, board independence, ownership concentration, audit reputation, management ownership, and institutional ownership are the independent variables considered in this study. In contrast, control variables were defined as firm size, liquidity, profitability, and growth. In order to determine how corporate governance affects capital structure in a sample of 395 non-financial companies listed on the Indonesia Stock Exchange, this study employs multiple linear regression analysis.
Result: The capital structure is significantly impacted negatively by board size, ownership concentration, firm size, profitability, and growth while positively impacted by independent commissioners, auditor reputation, managerial ownership, and institutional ownership. Liquidity has no impact on the capital structure.
Faktor-Faktor yang Mempengaruhi Kinerja Karyawan pada Perusahaan Creative Agency di Jakarta Barat
Authors: Wijaya Mishell Anita , Yanuar Yanuar 
Published: February 2024

Sumber daya manusia merupakan aspek krusial yang harus diperhatikan oleh perusahaan karena kinerja perusahaan yang optimal bergantung pada prestasi karyawan. Faktor-faktor seperti lingkungan kerja, kompensasi, karakter individu, dan motivasi diidentifikasi sebagai elemen penting yang mempengaruhi kinerja karyawan dalam konteks perusahaan. Lingkungan kerja yang positif, pemberian kompensasi yang sesuai, karakter individu yang baik, dan motivasi yang tinggi dapat meningkatkan kinerja karyawan, dan sebaliknya. Penelitian ini empiris menguji hubungan antara lingkungan kerja, kompensasi, dan karakter individu terhadap kinerja karyawan, dengan motivasi sebagai variabel mediasi di Perusahaan XYZ di Jakarta Barat, berdasarkan model konseptual dual factor theory. Karyawan Perusahaan XYZ di Jakarta Barat menjadi populasi penelitian, dengan 195 responden sebagai sampel. Metode kuantitatif digunakan dengan pengumpulan data melalui teknik purposive sampling dan distribusi kuesioner via Google Form. Hasil penelitian menggunakan SmartPLS menunjukkan bahwa lingkungan kerja, karakter individu, dan motivasi berpengaruh positif dan signifikan terhadap kinerja karyawan. Sementara kompensasi tidak memiliki pengaruh signifikan terhadap kinerja karyawan. Selain itu, lingkungan kerja, kompensasi, dan karakter individu juga berpengaruh positif dan signifikan terhadap motivasi kerja, dan motivasi mampu memediasi pengaruh kompensasi terhadap kinerja karyawan.

Human resources are a crucial aspect that companies must pay attention to because the optimal performance of a company depends on the achievements of its employees. Factors such as the work environment, compensation, individual characteristics, and motivation are identified as essential elements influencing employee performance in a corporate context. A positive work environment, appropriate compensation, good individual characteristics, and high motivation can enhance employee performance, and vice versa. This empirical research examines the relationship between the work environment, compensation, and individual characteristics on employee performance, with motivation as a mediating variable at Company XYZ in West Jakarta, based on the conceptual dual factor theory model. The employees of the Creative Agency in West Jakarta serve as the research population, with 195 respondents as the sample. A quantitative method is employed, utilizing purposive sampling techniques and distributing questionnaires via Google Form for data collection. The research results, analyzed using smartPLS, indicate that the work environment, individual characteristics, and motivation have a positive and significant impact on employee performance. Meanwhile, compensation does not have a significant influence on employee performance. Additionally, the work environment, compensation, and individual characteristics also positively and significantly affect work motivation, and motivation can mediate the influence of compensation on employee performance.
Penyelenggaraan Pos Upaya Kesehatan Kerja Terintegrasi di Desa Wisata Kasongan, Bantul- D.I. Yogyakarta
Authors: Agustin Helfi , Arianto Machfudz Eko , Rifai Muchamad 
Published: February 2024

Puskesmas yang telah menyelenggarakan pos UKK di D.I Yogyakarta berjumlah 222 di tahun 2022. Dari penelitian terdahulu, sebagian besar pelaksanaan program pos UKK belum spesifik. Pos UKK Kasongan Sehat berada di Desa Wisata Kasongan dengan daya tarik desa wisata menjadikan proses produksi gerabah sebagai wisata edukasi disamping penjualan produksi gerabah di desa wisata secara ecer maupun demo produk yang akan di ekspor, sehingga sangat perlu ditingkatkan keselamatan dan kesehatan pekerjanya. Penelitian kualitatif ini bertujuan melakukan analisis penyelenggaraan upaya kesehatan terintegrasi di pos UKK Kasongan Sehat Bantul. Informan penelitian ditetapkan dengan teknik purposive sampling terdiri dari 1 orang programer kesehatan kerja di Puskesmas Kasihan 1, 2 orang kader pos UKK Kasongan Sehat, 5 orang pekerja di industri gerabah di Kasongan, dan 1 orang dukuh. Teknik pengumpulan data indepth interview dan observasi. Data dianalisis dengan metode content analysis. Temuan penelitian; dasar penyelenggaraan pos UKK adalah peraturan Bupati Bantul nomor 42 tahun 2015. Pos UKK ini telah menerapkan pos UKK terintegrasi sesuai Permenkes nomor 100 tahun 2015, terlihat dari upaya kesehatan kerja yang terintegrasi dengan kegiatan posyandu. Kegiatan rutin tanggal 20 setiap bulan meliputi pengukuran tekanan darah, berat badan, P3K dan pemberian rujukan ke puskesmas. Puskesmas telah menyalurkan sarana dan prasarana dan menyelenggarakan pelatihan pertolongan pertama untuk penanganan luka bagi kader. Upaya kesehatan kerja oleh kader di pos UKK Kasongan masih fokus pada cara pandang sakit atau paradigma yang menekankan upaya kuratif karena kurangnya pelatihan tentang Keselamatan dan Kesehatan Kerja baik pada pembina maupun kader pos UKK. Dibutuhkan pelatihan dan pembinaan yang spesifik tentang K3 bagi pembina maupun kader pos UKK di puskesmas.
The Russian Fairy-Tale Heritage as an Object of Intangible Ethno-Cultural Heritage: Problems of Its Actualization and Use in Cultural Institutions
Authors: Добровольская В.Е. , Чернышева Ю.С. 
Published: February 2024

В связи с принятием Федерального закона «О нематериальном этнокультурном достоянии Российской Федерации» особенно важным стал вопрос о взаимодействии ученых и работников культуры не только в сфере выявления и изучения объектов этнокультурного достояния, но и в направлении использования, актуализации, сохранении и популяризации. Можно выделить ряд форм работ с русским сказочным наследием: и выпуск сказочных сборников, и проекты культурно-просветительского характера. Последние включают в себя научно-популярные лекции, фестивали, посвященные сказкам и сказочникам, подкасты, выступления людей, исполняющих фольклорные сказки, издания на компакт-дисках и многое другое. К сожалению, в настоящее время в большинстве случаев мы наблюдаем либо исследовательскую работу ученых, связанную с публикацией полевых архивных материалов, анализом сказочной традиции региона или творческого наследия конкретных сказочников, либо, напротив, различные проекты фестивального характера, которые проводят специалисты культурно-досуговых учреждений. В данной работе мы рассмотрим два эти направления в области работы со сказками на примере Псковской, Нижегородской, Смоленской, Ульяновской областей, Республики Карелия и других регионов России и остановимся на уникальном опыте Пермского края, представляющего собой результат совместной работы представителей науки и культуры.
In connection with the adoption of the Federal Law “On Intangible Ethno-Cultural Heritage of the Russian Federation,” the interaction between scholars and cultural workers has become particularly important not only for identifying and studying objects of ethno-cultural heritage, but also in the ways they are used, their preservation and popularization. There are many ways of working with the Russian fairy-tale heritage, including the publication of fairytale collections and cultural and educational projects. The latter also include popular lectures, festivals dedicated to fairy-tales and storytellers, podcasts, performances of folk tale performers, the publication of folk tales on CDs. Unfortunately, in most cases, at present we observe either scholarly work related to the publication of field archival materials, the analysis of the fairy-tale tradition of a particular region or the creative heritage of specific storytellers, or, on the contrary, we see projects of a festival nature, which are carried out by specialists of cultural and leisure institutions. In this paper, we will consider these two areas in the field of fairy-tales on the example of Pskov, Nizhny Novgorod, Smolensk, Ulyanovsk regions, the Republic of Karelia and other regions of Russia, and also focus on the unique experience of the Perm region which is the result of joint work by representatives of academia and of culture.
Confirmatory Factor Analysis Applied to the Business Model of the Artisan Sector, case of Tenango de Doria, Hidalgo, Mexico
Authors: Cordero Gabriela Ortiz , Mohedano Gisela Yamin Gómez , Alonso Maria Teresa Sarabia 
Published: February 2024

Purpose: The purpose of this study is to examine the applicability and effectiveness of the Canvas Model in the artisan sector, specifically focusing on microenterprises in Tenango de Doria, Hidalgo, Mexico. The goal is to understand how the various components of the Canvas Model influence the success of local handicrafts, identifying key factors for their development and sustainability.

Theoretical Framework: The study is based on the theoretical foundations of the Canvas Model, which includes nine key elements crucial for business success. Recent literature highlights the need for tailored business strategies in artisan sectors, recognizing the unique challenges and opportunities they present.

Design/Methodology/Approach: A cross-sectional and correlational quantitative research design is adopted. Surveys are conducted with 401 potential customers of "Tenango" handicrafts, followed by a confirmatory factor analysis to evaluate the nine key elements of the Canvas Model.

Findings: The findings underscore the importance of 'sales', 'distribution channels', and 'innovation' in the Canvas Model within the artisan sector, while 'key partners' emerge as less significant. These findings suggest the need to adapt the Canvas Model to the artisanal context, focusing on effective sales and distribution strategies and strengthening the unique value proposition of the crafts.

Research, Practical & Social Implications: This pioneering study provides a solid foundation for future research in the artisan sector and offers valuable insights for the development of business strategies. The findings have significant implications not only for the artisans of Tenango de Doria but also for other artisan contexts, potentially guiding the development and sustainability of micro-enterprises in various cultures and regions.

Originality/Value: The study marks a novel approach by applying a quantitative analysis to assess the Canvas Model in the artisan sector, highlighting the complexities of formulating a successful business model in this field and contributing valuable perceptions for its development and sustainability.
The Novel "Anak Rantau" by A. Fuadi as an Idea for Creating Illustrations
Authors: Aldiansyah Muhammad , Fitryona Nessya 
Published: February 2024

This article discusses the illustrations from the novel "Anak Rantau" by A. Fuadi, intended as a catalyst for solutions to address issues related to teenage reading interest (literacy) and moral crisis. The illustrations aim to motivate teenagers to engage in reading. By presenting illustrations from the novel "Anak Rantau," it is hoped that teenagers will be intrigued to understand the novel's content, resulting in moral outcomes aligned with the ethical values conveyed by the novel. The illustrations employed in this work are of the digital kind, reflecting the advancements in digitally based illustration techniques in this era of globalization. The technique involves a manual combination executed with the assistance of the Medibang application for digitization. Pens, watercolors, and oil pastels serve as the tools and materials used to sketch, color, and finalize the artwork, which is then transferred onto a digital canvas measuring 40 x 60 cm. From this discussion, it can be concluded that this work constitutes illustrations as an alternative solution, employing an approach that utilizes illustrations as catalysts to enhance reading quality, ultimately culminating in the moral improvement of teenagers
Enhancing diagnostic precision: Electromagnetic navigation bronchoscopy with cryobiopsy in pulmonary and mediastinal lesions – A case study
Authors: Kordykiewicz Dawid , Szaj Monika , Pieróg Jarosław , Ptaszyński Konrad , Grodzki Tomasz , Wójcik Janusz , Szymański Jacek , Witkiewicz Karina , Wojtyś Małgorzata Edyta 
Published: February 2024

IntroductionA minimally invasive approach in the diagnosis of peripheral pulmonary lesions may pose a challenge for thoracic surgeons when selecting the most appropriate technique. Electromagnetic navigation bronchoscopy (ENB) is an innovative technique used in the diagnosis of lung tumors.AimEvaluation of the merits of ENB in patient manifesting undiagnosed pulmonary and mediastinal lesions, while concurrently investigating its influence on the determination of the ultimate therapeutic strategy.Case studyThe 73-year-old male patient with a suspicious lung mass was admitted to the hospital for diagnosis and subsequent treatment. The patient underwent an invasive diagnosis of lung and mediastinum using ENB with cryobiopsy. The histopathological examination revealed adenocarcinoma and lymphoma cells, ultimately guiding the initiation of appropriate therapeutic measures.Results and DiscussionAmong the available methods, those with the highest diagnostic yield and safety should be chosen. Precise diagnosis of pulmonary lesions holds paramount importance for guiding appropriate treatment in cases of suspected malignancy.ConclusionsENB with cryobiopsy proves effective diagnosis in case of peripheral lesions that are difficult to access for classical techniques.
Low transverse caesarean section through the posterior uterine wall in a pregnant patient with asymptomatic uterine torsion of 180°: A case report
Authors: Kopko Jarosław , Marek Jakub , Laskowski Wojciech 
Published: February 2024

IntroductionExcessive torsion of a pregnant uterus is a rare and potentially extremely dangerous pathology for both the mother and fetus. The diagnosis is most often made intraoperatively.AimThe main aim was to show that when it is impossible to detort the uterus, a low transverse caesarean section through the posterior uterine wall can be safely performed.Case studyWe report a case of a 41-year-old multiparous woman at G II P II 39/40 weeks' gestation, who presented to the Gynecology and Obstetrics Department for an elective caesarean section due to a breech presentation of the fetus. During the caesarean section, a uterine torsion of 180° was found. As the uterus could not be detorted to its normal position, a low transverse caesarean section was performed through the posterior uterine wall. At follow-up visits after 8 weeks and 12 months, normal healing of the uterine muscle was confirmed.Results and discussionThe treatment of torsion of the pregnant uterus depends on gestational age and symptoms, in particular the presence of significant hemodynamic and ischemic lesions.ConclusionsThe procedure of choice in a full-term pregnancy should be an attempt to detort the uterus to its normal position and then perform a cesarean section through the anterior uterine wall. If detorsion of the uterus is not possible, a caesarean section through the posterior uterine wall should be performed. Based on the literature review and the case presented, it appears that this procedure is safe.