bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, Biochemical and Molecular Features of a Cohort of 8 Patients with Inherited Disorders of Vitamin B12 Metabolism in a Metabolic Reference Center
Authors: Padeira Gonçalo , Jacinto Sandra , Ribeirinho Augusto , Ferreira Ana Cristina 
Published: October 2023

Background:
Vitamin B12, or cobalamin (Cbl), undergoes a complex series of absorptive
and intracellular processing steps before serving as a cofactor for the enzymes
methylmalonyl-CoA mutase and methionine synthase. Disorders of intracellular cobalamin metabolism
have variable phenotypes and age of onset related to the location of the defect in the
metabolic pathway leading to a combined methylmalonic acidemia and homocystinuria (cblC,
cblD, cblF and cblJ), Isolated methylmalonic acidemia (cblA, cblB and cblDv2) and isolated
homocystinuria (cblDv1, cblE and cblG).

Objective and Methods:
We conducted a retrospective study of the clinical biochemical and
molecular features of a cohort of patients with disorders of intracellular Cbl metabolism followed
in our Reference Centre of Inherited Metabolic Diseases (CR-IMD) for the last 23 years
(2000-2023).

Results:
CblC: P1 and P2, pré-newborn screening (NBS), had an early and severe presentation
evolving to multiorgan failure and death. P3 was asymptomatic at NBS with an excellent evolution
except for nystagmus and retinitis pigmentosa. P4 presented at 19Y with an atypical hemolytic
uremic syndrome and is presently on hemodialysis. CblD: P5 had a developmental delay
(DD) and hypotonia and presented at 14m with seizures. CblDv2: P6 had DD and failure to
thrive (FTT) and presented at 4Y with acute metabolic acidosis. CblDv1: P7 had DD, FTT, and
hypotonia and presented at 16m with seizures and anemia. CblG: P8 had DD and FTT and presented
at 15m with macrocytic anemia. In all, characteristic biochemical profiles guided the diagnosis,
afterward confirmed by genetic analysis (4 MMACHC, 3 MMADHC, 1 MTR). All
patients received either betaine, hydroxycobalamin, or both (P3 is on a very high dosage).

Conclusion:
Our cohort of patients has similar clinical and biochemical characteristics to the
ones described in the literature. Outcomes of patients reinforce the importance of newborn
screening and the need for consensus guidelines for optimal doses of parenteral hydroxocobalamin.
A Comprehensive Review on Sophora japonica: Ethnomedicinal,
Phytochemistry & Pharmacological Aspects
Authors: Ghatti Srivalli Susmitha , Garaga Machiraju , Chatterjee Arnab , Thimmannagari Sravani , Cherupalli Sree Ramya , Hebbani Nagarajappa Shivaprasad , Krishnamani Madhu , Soni Gaurav 
Published: October 2023

Abstract:
Sophora japonica, a species of Sophora, one of the prominent genera, belongs to the family
Fabaceae, native to China, which is commonly known as a pagoda tree. Sophora, includes nearly
52 species, nineteen varieties and many of these species have been used in traditional Chinese medicine
to cure various ailments. This review compiles its ethnomedical uses, diverse phytochemicals
reported from the various parts of S. japonica, and their pharmacological effects to elucidate its therapeutic
potential against a wide range of diseases. Traditionally it is used to treat various hematic
disorders such as hypertension, hemorrhoids, hemorrhage, hematuria, hematochezia, dysentery, arteriosclerosis,
etc. Moreover, each and every part of this plant, including the flowers, buds, leaves,
bark, fruits, seeds, pericarp, stems, and roots are used as medicine, particularly in China, Japan, Korea,
and Asia. Chinese Pharmacopoeia and European Pharmacopoeia describe the utility of this plant
since ancient times. The enhanced use of S. japonica in Chinese medicine resulted in the exploration
of various phytochemicals and their pharmacological properties includes in vitro, in vivo, and clinical
studies. It is enchanted with steroids, phospholipids, flavonoids, isoflavonoids, alkaloids, triterpenes,
and other phenolic compounds that are characterized by therapeutic activities such as anti-oxidant,
anticancer, anti-asthmatic, anti-neoplastic, antimicrobial, antiviral, antidote, anti-pyretic, cardiotonic,
anti-inflammatory, diuretic, anti-platelet, anti-hyperglycemic, immunomodulatory, anti-diabetic,
estrogenic and anti-osteoporotic activity in post-menopausal women etc. and this is also used as a
remedy for skin diseases like eczema, colpitis and psoriasis. Despite its health benefits, supplementary
data is still required in order to bridge the gaps and ensure the possible safety profile by conducting
clinical studies for its therapeutic applications as a natural and eminent safe drug.
PV Array Reconfiguration for Global Maximum Power Optimizing under Partial Shading Conditions based on PV Switched System
Authors: Abdelaziz Mohamed M. , Sharaf Soliman M. , El Zoghby Helmy M. 
Published: October 2023

Background:
Due to the partial shading effects on different photovoltaic (PV) modules
in a PV array, PV module operating conditions are inconsistent, and PV array output power is significantly
reduced. Although the maximum power point (MPP) of a non-uniform irradiance PV
array can be observed through global maximum power point tracking (GMPPT), no evaluation of
the array's energy potential has been done.

Objective:
One of the most effective solutions to overcome the negative effects of partial shading
in PV systems is the PV array reconfiguration process. To optimize the electrical structure of the
PV array as the PV modules are partially shaded in a non-uniform manner, this study proposes a
promising technique for dynamic reconfiguring a PV array in order to improve the extracted maximum
power from a PV array under partial shading conditions (PSC).

Methods:
PV modules are rearranged by iteratively sorting them to allow the PV array with nonuniform
irradiance to produce as much power as possible. This is conducted by applying a switching
matrix to implement a PV-switched system approach. The proposed system with different PV
array dimensions (e.g., 3×4, 4×6, and 5×8) is assessed in order to validate the proposed algorithm. A
MATLAB/Simulink PV array developed model is used to find the global maximum power point for
the different PV array dimensions in both pre-reconfiguration and post-reconfiguration states.

Results:
A detailed numerical comparison of the extracted power from the proposed system has
been provided.

Conclusion:
The results show that the proposed system has the potential to extract the exact global
maximum power for a PV-switched system under PSC, irrespective of array dimensions, according
to simulation results.
High-precision Prediction Method of Electric Vehicle Trading Power
based on Neural Network
Authors: Wei Wei , Ye Li , Fang Yi , Wang Yingchun , Zhong Yue , Zhang Chenghao , Li Zhenhua 
Published: October 2023

Introduction:
Electric vehicles have become a development trend due to their good
environmental protection and energy saving, etc. Prediction of electric vehicle charging volume
can help relevant departments optimize power supply, service, and construction.

Methods:
In this paper, the Support Vector Machine (SVM) model and the combined Long Short
Term Memory (LSTM) and Support Vector Regression (SVR) prediction model are constructed for
the prediction of charging capacity, and simulated by actual trading power data in Hubei Province.

Results:
The results show that the prediction effect of the two methods is good, and the LSTMSVR
algorithm is judged to have better performance and less error in predicting the fluctuation of
transaction power.

Conclusion:
LSTM-SVR can be used as a charging prediction method to provide a reference basis
for the power control strategy of electric vehicles charging management platform, which is conducive
to the healthy development of electric vehicles industry.
A Shunt DC Electric Spring Control Strategy for MVDC Bus Voltage Stability Onboard AES
Authors: Radhakrishnan Remna , Chacko Mariamma 
Published: October 2023

Background:
The recent trend in the all-electric ship (AES) electrical systems, especially
in military vessels, is to move towards medium voltage direct current (MVDC) distribution.
Bus voltage instability is a major issue in direct current (DC) distribution systems. Nowadays,
direct current electric springs (DCES) are extensively used in low-voltage direct current (LVDC)
microgrids to address voltage instability issues. This paper extends the use of a shunt DCES to
stabilize the bus voltage in an MVDC grid. The work proposes an addition to the MVDC onboard
ship distribution system architecture, described in IEEE 1709, by integrating a shunt DCES with a
novel control strategy to stabilize the bus voltage under various loading conditions, including propulsion
motor (PM) and online pulsed power load (PPL).

Methods:
The shunt DCES is designed to provide current into the MVDC bus, which reduces the
bus current ripple to attain a stable bus voltage with reduced ripple. A dual loop control with a
battery management system (BMS) is proposed for the shunt DCES and simulated in
MATLAB/Simulink. BMS is designed based on the state of charge (SOC) of the battery and bus
current ripple extracted from the system's source and load side currents. The current supplied by
the shunt DCES and the extracted ripple current validate the effectiveness of the proposed control.
Total harmonic distortions (THDs) as a measure of voltage ripple of the MVDC bus voltage at
different intervals are measured and compared for both systems, with and without shunt DCES.

Results:
It was observed that the shunt DCES could reduce the voltage ripple well below the permissible
limit, which is 5% as per IEEE 1709.

Conclusion:
The proposed control strategy could attain a reduction of 68-85% in THD under peak
to off-peak loading conditions with the addition of shunt DCES.
Insights on Natural Products Against Amyotrophic Lateral Sclerosis
(ALS)
Authors: Monteiro Kadja Luana Chagas , dos Santos Alcântara Marcone Gomes , de Aquino Thiago Mendonça , da Silva-Júnior Edeildo Ferreira 
Published: October 2023

Abstract:
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes
the death of motor neurons and consequent muscle paralysis. Despite many efforts to address it, current
therapy targeting ALS remains limited, increasing the interest in complementary therapies. Over
the years, several herbal preparations and medicinal plants have been studied to prevent and treat this
disease, which has received remarkable attention due to their blood-brain barrier penetration properties
and low toxicity. Thus, this review presents the therapeutic potential of a variety of medicinal herbs
and their relationship with ALS and their physiopathological pathways.
Inflammation, Autoimmunity and Neurodegenerative Diseases,
Therapeutics and Beyond
Authors: Garmendia Jenny Valentina , De Sanctis Claudia Valentina , Das Viswanath , Annadurai Narendran , Hajduch Marián , De Sanctis Juan Bautista 
Published: October 2023

Abstract:
Neurodegenerative disease (ND) incidence has recently increased due to improved life expectancy. Alzheimer's (AD) or Parkinson's disease (PD) are the most prevalent NDs. Both diseases are poly genetic, multifactorial and heterogenous. Preventive medicine, a healthy diet, exercise, and controlling comorbidities may delay the onset. After the diseases are diagnosed, therapy is needed to slow progression. Recent studies show that local, peripheral and age-related inflammation accelerates NDs' onset and progression. Patients with autoimmune disorders like inflammatory bowel disease (IBD) could be at higher risk of developing AD or PD. However, no increase in ND incidence has been reported if the patients are adequately diagnosed and treated. Autoantibodies against abnormal tau, β amyloid and α- synuclein have been encountered in AD and PD and may be protective. This discovery led to the proposal of immune-based therapies for AD and PD involving monoclonal antibodies, immunization/vaccines, pro-inflammatory cytokine inhibition and anti-inflammatory cytokine addition.
All the different approaches have been analysed here. Future perspectives on new therapeutic strategies for both disorders are concisely examined.
Smoking, Symptoms Improvement, and Total Antioxidant Capacity in
Patients with Drug-naive First-episode Schizophrenia: A Prospective
Cohort Study
Authors: Gao Zhiyong , Xiu Meihong , Liu Jiahong , Wu Fengchun , Zhang Xiangyang 
Published: October 2023

Background:
It has been hypothesized that smoking is associated with the severity of negative
symptoms. Until now, no studies have investigated whether the impact of smoking on negative
symptoms is dependent on antioxidants. This study was designed to evaluate the effect of smoking on
therapeutic response and total antioxidants capacity (TAOC) in antipsychotic-naïve first-episode
(ANFE) patients.

Methods:
The severity of the patient’s symptoms was assessed using the Positive and Negative
Syndrome Scale (PANSS). A total of 237 ANFE patients were recruited and treated with risperidone
(oral tablets, 4-6 mg/day twice a day) for 12 weeks. PANSS was assessed at baseline and a 12-week
follow-up. Plasma TAOC levels were also assayed at baseline and week 12.

Results:
Relative to nonsmokers with ANFE SZ, smokers had higher PANSS negative subscores.
There was no significant difference in TAOC changes after 12 weeks of treatment with risperidone between
smokers and non-smokers. However, we found greater improvement in negative symptoms in
smokers compared to non-smokers. Further analysis in smokers with SZ demonstrated that improvements
in negative symptoms were not associated with changes in TAOC.

Conclusion:
Our study suggested that smoking affected the severity of baseline negative symptoms
and further contributed to their reduction after risperidone treatment. However, improvement in negative
symptoms was not dependent on the changes in TAOC.
Integrating Clinical Decision Support Into Electronic Health Record Systems Using a Novel Platform (EvidencePoint): Developmental Study
Authors: Solomon Jeffrey , Dauber-Decker Katherine , Richardson Safiya , Levy Sera , Khan Sundas , Coleman Benjamin , Persaud Rupert , Chelico John , King D'Arcy , Spyropoulos Alex , McGinn Thomas 
Published: October 2023

Background
Through our work, we have demonstrated how clinical decision support (CDS) tools integrated into the electronic health record (EHR) assist providers in adopting evidence-based practices. This requires confronting technical challenges that result from relying on the EHR as the foundation for tool development; for example, the individual CDS tools need to be built independently for each different EHR.

Objective
The objective of our research was to build and implement an EHR-agnostic platform for integrating CDS tools, which would remove the technical constraints inherent in relying on the EHR as the foundation and enable a single set of CDS tools that can work with any EHR.

Methods
We developed EvidencePoint, a novel, cloud-based, EHR-agnostic CDS platform, and we will describe the development of EvidencePoint and the deployment of its initial CDS tools, which include EHR-integrated applications for clinical use cases such as prediction of hospitalization survival for patients with COVID-19, venous thromboembolism prophylaxis, and pulmonary embolism diagnosis.

Results
The results below highlight the adoption of the CDS tools, the International Medical Prevention Registry on Venous Thromboembolism-D-Dimer, the Wells’ criteria, and the Northwell COVID-19 Survival (NOCOS), following development, usability testing, and implementation. The International Medical Prevention Registry on Venous Thromboembolism-D-Dimer CDS was used in 5249 patients at the 2 clinical intervention sites. The intervention group tool adoption was 77.8% (4083/5249 possible uses). For the NOCOS tool, which was designed to assist with triaging patients with COVID-19 for hospital admission in the event of constrained hospital resources, the worst-case resourcing scenario never materialized and triaging was never required. As a result, the NOCOS tool was not frequently used, though the EvidencePoint platform’s flexibility and customizability enabled the tool to be developed and deployed rapidly under the emergency conditions of the pandemic. Adoption rates for the Wells’ criteria tool will be reported in a future publication.

Conclusions
The EvidencePoint system successfully demonstrated that a flexible, user-friendly platform for hosting CDS tools outside of a specific EHR is feasible. The forthcoming results of our outcomes analyses will demonstrate the adoption rate of EvidencePoint tools as well as the impact of behavioral economics “nudges” on the adoption rate. Due to the EHR-agnostic nature of EvidencePoint, the development process for additional forms of CDS will be simpler than traditional and cumbersome IT integration approaches and will benefit from the capabilities provided by the core system of EvidencePoint.
A Relationship-Based Resilience Program for Promotores: Protocol for a Randomized Controlled Waitlist Trial
Authors: Arcos Daniela , Russo Lyric N , Kazmierski Kelly F M , Zhou Elayne , Montiel Gloria Itzel , Bracho America , Mejia Nancy , Borelli Jessica L 
Published: October 2023

Background
Community service providers (CSPs) play an integral role in the health care of low-income Hispanic or Latinx (HL) communities. CSPs have high-stress frontline jobs and share the high-risk demographics of their communities. Relational savoring (RS) has been associated with lower cardiovascular reactivity and psychosocial benefits, with particular promise among HL participants. In this study, we aim to identify RS’s potential in promoting CSPs’ cardiometabolic health and, in so doing, having broader impacts on the community they serve.

Objective
This randomized controlled waitlist study aims to examine the effect of an RS intervention on (1) CSPs’ cardiometabolic health (cardiometabolic risk factors and outcomes) and (2) CSPs’ threats to leaving the workforce.

Methods
We will recruit a sample of 80 CSPs from community health agencies serving low-income HL populations. Participating CSPs will be randomized into an experimental or a waitlist control. Participants will complete 1 or 2 baseline assessment batteries (before the intervention), depending on the assigned group, and then complete 2 more assessment batteries following the 4-week RS intervention (after the intervention and at a 3-mo follow-up). The RS intervention consists of guided reflections on positive moments of connection with others. Electrocardiogram data will be obtained from a wearable device (Polar Verity Sense or Movisens) to measure heart rate variability. The primary outcome is cardiometabolic health, consisting of cardiometabolic risk (obtained from heart rate variability) and cardiometabolic health behaviors. The secondary outcomes include CSPs’ threats to leaving the workforce (assessed via psychological well-being), intervention acceptability, and CSPs’ delivery of cardiometabolic health programming to the community (exploratory). Analyses of covariance will be used to examine the effects of RS on cardiometabolic health and on CSPs’ threats to leaving the workforce, comparing outcomes at baseline, postintervention, and at follow-up across participants in the experimental versus waitlist group.

Results
The study has been approved by the University of California, Irvine, Institutional Review Board and is currently in the data collection phase. By May 2023, 37 HL CSPs have been recruited: 34 have completed the baseline assessment, 28 have completed the 4 intervention sessions, 27 have completed the posttreatment assessment, and 10 have completed all assessments (including the 3-mo follow-up).

Conclusions
This study will provide valuable information on the potential of RS to support cardiometabolic health in HL CSPs and, indirectly, in the communities they serve.

Trial Registration
ClinicalTrials.gov NCT05560893; https://clinicaltrials.gov/study/NCT05560893

International Registered Report Identifier (IRRID)
DERR1-10.2196/51427
Status gizi pada siswi remaja di pondok pesantren modern
Authors: Naufalina Mira Dian , Nabawiyah Hafidhotun , Sari Dianti Desita 
Published: October 2023

Nutritional status of female students in Modern Islamic boarding schoolBackground: Female students in Islamic Boarding schools whose adolescents, in the majority, need attention because of their physiological condition in the future. Similar studies in Indonesia with significant subjects of adolescent girl students still need to be expanded. Objective: We aim to find out the prevalence of the nutritional status of adolescent girl students in Islamic Boarding Schools. Methods: The study used a cross-sectional design and had 435 respondents from grades 1-6 (11-19 years old) in Darussalam Gontor Modern Islamic Boarding School for Girls 1. The study measured anthropometrics such as weight, height, and middle-upper arm circumference (MUAC). The following variable was nutritional status which is classified based on Body Mass Index-for-age (BAZ) and height-for-age (HAZ) Z-score, as well as chronic energy deficiency (CED) status. Results: Most subjects (77%) were classified as having normal nutritional status based on BMI-for-age. However, there were 47.6% of students experienced CED, and 15.2% of students were stunted based on height-for-age. Nutritional status according to BMI-for-age showed that 72.73% of students with normal nutritional status and 22.75% of students with overweight were found to be stunted. Notably, among the students with normal nutritional status based on BMI-for-age, the majority were also found to have CED (95.65%). Conclusion: The prevalence of adolescent female students with underweight and severe underweight nutritional status based on BMI-for-age was 1.84%, whereas the prevalence of overweight and obesity was 20.92%. Additionally, 47.6% of female students experience CED, and 15.2% are classified as stunting based on height-for-age.
Pendidikan gizi dengan media animasi dalam upaya memperbaiki kadar hemoglobin dan asupan gizi ibu hamil anemia
Authors: Tarigan Novriani , Bangun Sartini , Doloksaribu Bernike , Sihotang Urbanus 
Published: October 2023

Nutrition education with animated media to improve hemoglobin levels and nutritional intake of anemic pregnant womenBackground: The prevalence of anemia among pregnant women in 2018 increased compared to 2013. Anemic pregnant women need to receive nutrition education. Nutrition education requires media and various studies that report the success of nutrition education using various media. Objective: This study aimed to analyze the effect of animated media nutrition education on improving hemoglobin and nutrient intake of anemic pregnant women. Methods: The study was quasi-experimental with a pretest-posttest one-group design on 31 anemic pregnant women. Nutrition education media, namely animated videos, were prepared based on interviews with cadres and pregnant women. Hemoglobin levels, knowledge, attitudes, iron tablet consumption compliance, and nutrient intake were measured before and after being given animated media nutrition education. Results: The mean hemoglobin level of pregnant women after the intervention increased by 1.75 g/dl; knowledge score 3.52; behavior score 4.06; iron tablet consumption 28 grains; energy intake 574.62 Kcal; protein intake 19.46 g; vitamin C intake 25.98 mg; and iron intake 3.17 mg. Conclusion: Nutrition education intervention using animated video can improve hemoglobin level, knowledge, attitude, iron tablet consumption, and nutritional intake of pregnant women.