bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empowering Education with Augmented Reality: Planetarium Virtual Laboratory Development Society 5.0 Era
Authors: Nisa' Rofiatun , Isroil Ahmad 
Published: February 2025

Elementary school students in the Society 5.0 era have become accustomed to advanced technology. Therefore, teachers must make smart efforts to ensure the success of quality education. This research aims to analyze product practicality and product feasibility according to experts to support quality education for elementary school students in the Society 5.0 era. This study's Research and Development (RnD) method follows the ADDIE model. The research was conducted with sixth-grade elementary school students in Lamongan Regency, with 166 participants. Data analysis utilized interview and questionnaire techniques. The research results are as follows: The first stage involved analyzing the needs of teachers and students in IPAS learning that could support quality education relevant to the current era. The next stage was designing the learning media. After the design process, the learning media was developed and validated by two expert media validators, two science subject matter validators, and ten education practitioners in the very good category. The implementation results with sixth-grade students at Madrasah Ibtidaiyah in Lamongan showed that 90% of the students rated the media in the outstanding category. Thus, it can be concluded that this virtual planetarium laboratory media is effectively applied to sixth-grade students in science learning to support quality education in the Society 5.0 era.
Ketahanan Kultivar Pisang Lokal Kalimantan Selatan terhadap Penyakit Bercak Sigatoka (Mycosphaerella sp.)
Authors: Mariana Mariana , Rodinah Rodinah , Budi Ismed Setya 
Published: February 2025

Sigatoka of banana caused by Mycospherella sp. is an important disease, since it causes yield losses. Resistant variety is considered a promising approach for sigatoka disease management. This study was aimed to evaluate the resistance of local banana cultivars from South Kalimantan against sigatoka disease. The fungus was isolated from leaves of Kapas cultivar showing severe symptoms of sigatoka disease, onto potato dextrose agar medium. The isolate was then confirmed as Mycosphaerella sp. following Koch’s postulate. Level of resistance is determined based on symptoms development. Resistance of local banana cultivars can be differentiated into susceptible (‘Awak’, ‘Jaranang’, ‘Kapas’, ‘Mas’, and ‘Paikat’), medium resistant (‘Ambon’, ‘Kepok’, ‘Mas Bantan’, ‘Mauli’, and ‘Talas’), and resistant (‘Tarati’). In general, the symptom was visible 2 to 8 days after inoculation. The longer incubation period the more resistant response of banana varieties. Incubation period was negatively correlated to the disease intensity, but it is not correlated with stomatal density.
Training robust neural networks for uncertainty prediction in stamping technology
Authors: Koller Lukas , Hartmann Christoph , Martinitz Lukas , Volk Wolfram , Althoff Matthias 
Published: February 2025

Abstract
Stamping and bending technology uses a sequence of stamping and bending steps to manufacture complex metal parts. The execution order and design of each step are crucial for the quality of a produced part. However, simulating different process orders is hard due to uncertainties in the production process. We propose a data-driven model using neural networks to optimize the execution order to reduce the effects of uncertainties on the deviation in product quality. The process steps are modeled individually by neural networks, which are concatenated to model different process orders. To ensure accurate predictions, we use set-based training to make the neural networks robust against input uncertainties. We demonstrate the usefulness of our model by numerical experiments for the production process of a busbar.
Robuste Inline-Rekonstruktion geometrischer Merkmale in der Blechumformung auf Basis von Laserprofilsensoren
Authors: Nagel Malte , Brower-Rabinowitsch Max , Schmiele Dennis , Hinz Lennart , Krimm Richard , Behrens Bernd-Arno , Reithmeier Eduard 
Published: February 2025

Abstract
This paper presents a method for robust inline reconstruction of geometric features in sheet metal forming using commercially available line-scanning laser triangulation sensors. The goal is to achieve 100 percent inline component inspection to reduce scrap and improve efficiency. A ray tracing-based simulation approach is employed to assess uncertainties introduced by sensor limitations, shadowing, resolution constraints, and sensor noise. Additionally, a calibration procedure is presented, where a calibration object is used to verify and correct the laser plane’s alignment into a reference coordinate system. The reconstructed geometric features such as component heights and radii allow conclusions to be drawn about the component quality.
Robust Optimal Monetary Policies in Behavioral New Keynesian DSGE Models
Authors: Di Bartolomeo Giovanni , Serpieri Carolina 
Published: February 2025

Abstract
This paper addresses the challenge of uncertainty in monetary policy by incorporating local model uncertainty arising from heterogeneous expectations into a behavioral New Keynesian DSGE framework. Non-Bayesian control techniques are adopted to minimize a welfare loss derived from the second-order approximation of agents’ utilities to derive robust optimal policies. In the context of uncertainty regarding the formation of behavioral expectations, the importance of gradualism in monetary adjustments is emphasized. Policymakers should consider the ratio of rational to boundedly rational agents and anticipate that a significant presence of boundedly rational agents, especially those with long-horizon expectations, may require more dynamic adjustments to interest rates. Accounting for multidimensional uncertainty exponentially increases the complexity of the analysis and model indeterminacy.
Impact of fracture fixation surgery on cognitive function and the gut microbiota in mice with a history of stroke
Authors: Lu Yu , Li Zixuan , Xu Rukun , Xu Yajie , Zhang Wenwen , Zhang Yong , Fang Zhaojing , Pan Cailong , Wang Xiaoliang 
Published: February 2025

Abstract
Perioperative cognitive dysfunction is a common complication in stroke patients undergoing secondary surgeries. This study investigated the effects of tibial fracture internal fixation (TFIF) surgery on cognitive function and the gut microbiota in mice with a history of stroke. Using the middle cerebral artery occlusion method to induce stroke, we assessed cognitive function via the fear conditioning test and analyzed the gut microbiota through 16S rRNA sequencing. Compared with those in the normal and stroke groups, the cognitive function of the mice in the stroke group that underwent TFIF surgery was significantly impaired. Gut microbiota analysis revealed significant changes in beta diversity, but not in alpha diversity, in these mice. Additionally, TFIF surgery increased microglial activation and IL-1β and lipopolysaccharide (LPS) levels in the brain while reducing α-defensin levels and increasing IL-1β and LPS levels in the colon. These results suggest that TFIF surgery exacerbates cognitive impairment in stroke mice, possibly through alterations in the gut microbiota that impair intestinal defense and promote inflammation. This study highlights the critical role of the gut microbiome in cognitive function and perioperative outcomes, offering insights into potential therapeutic strategies for perioperative cognitive dysfunction in stroke patients.
Modelling drug permeation across the skin: a chemical engineering perspective
Authors: Sebastia-Saez Daniel , Chen Tao , Deacon Benjamin , Lian Guoping 
Published: February 2025

Abstract
This review provides insight on how the application of core chemical engineering concepts helps with current challenges in dermal permeation research from a mathematical modelling perspective. The skin fundamentally behaves like a diffusion reactor, where mass conservation featuring Fick’s diffusion flux can be applied to obtain the differential equations that govern the permeation of a chemical compound. Advanced phenomena like systemic circulation or complex thermodynamics can be added mathematically into the models to complement the diffusion equation. Depending on research objectives, the reach of these mechanistic continuum mechanics models can: i) consider the skin as a homogeneous compartment, where spatial dependency is overlooked, or ii) include detailed spatio-temporally-discretised geometric descriptions of complex features like the bricks-and-mortar layout of the stratum corneum. The capabilities of this powerful approach to study advanced topics in dermatological research are discussed. These include topics such as the role of the hair follicle as a shortcut to bypass the stratum corneum, the effect of evaporation during the application of multicomponent formulations, and the facilitation of skin permeation by means of external forces (i.e., electromagnetic fields and mechanical action). The chapter closes with a note on current challenges towards the future development of mechanistic skin Digital Twins, which are gaining further importance of late to avoid animal experimentation in dermatological research.
Epigallocatechin gallate mitigates the motor deficits in a rotenone-induced Parkinson’s disease rat model via promoting protein kinase D1 and inhibiting neuronal Parthanatos
Authors: Wang Jianjun , Tang Yaqi , Guo Chenwu , Du Zekun , Chen Fen , Fang Shujuan , Tang Yinjuan 
Published: February 2025

Abstract
Parkinson’s disease (PD), a neurodegenerative disorder characterized by degeneration of the dopaminergic (DA) neurons, is still lack of available treatments to completely block neurodegeneration. (−)-Epigallocatechin-3-gallate (EGCG), a predominant active polyphenol generated from green tea, exerts multiple neuroprotective roles in the nervous system. However, the function role of EGCG in PD and the underlying mechanism remains to be investigated. In the current study, we used the rotenone injection to build the PD rat model, followed by the EGCG treatment and determined by the behavior tests, measurements of malondialdehyde, glutathione, and superoxide dismutase levels, and enzyme-linked immunosorbent assay. We revealed that, in PD rats, EGCG upregulates protein kinase D1 (PKD1) and inhibits Parthanatos to ameliorate the impaired motor function, reduce the expression of tyrosine hydroxylase, suppress the oxidative stress, and suppress the inflammation in substantia nigra. These combined results suggest that EGCG can suppress oxidative stress and inflammation to prevent DA neuron degeneration to prevent rotenone-induced motor impairments, laying the foundation for EGCG to be a novel candidate for the treatment of PD.
Die Eröffnung des Sacharjabuches (Sach 1,1–6) als prophetentheologischer Programmtext
Authors: Behrens Achim 
Published: February 2025

Zusammenfassung
Die Eröffnung des Sacharjabuches in Sach 1,1–6 ist weniger eine Bußpredigt als vielmehr der Entwurf einer Theologie der alttestamentlichen Prophetie insgesamt. Die vorexilischen Propheten werden hier innovativ als die »früheren Propheten« bezeichnet. Deren Botschaft war demnach der Ruf »Kehrt um!«. Die damit verbundenen Drohungen sind eingetroffen, was wiederum ein Erweis für die Verlässlichkeit des Wortes Gottes für die zeitgenössische Leserschaft ist. So ist Sach 1,1–6 ein theologischer Programmtext, der für ein bestimmtes Bild der Prophetie Begriffe sucht und findet.
Wie hoch stieg das Wasser der Sintflut? Neue Überlegungen zu Gen 7,20
Authors: Tropper Josef , Vita Juan-Pablo 
Published: February 2025

Zusammenfassung
In diesem Artikel wird argumentiert, dass der hebräische Text von Genesis 7,20 anders zu verstehen ist als bisher angenommen wurde. Der adverbiale Ausdruck milemaˁlāh
bedeutet nicht »nach oben hin« bzw. »höher als«, sondern »von oben her (gemessen)«. Und der Bezugspunkt sind nicht die Spitzen der hohen Berge, sondern vielmehr die Unterseite des Himmels: »Das Wasser war auf (eine Höhe von) 15 Ellen von oben her angeschwollen«. Auf dem Höhepunkt der Flut fand die Arche, die 30 Ellen hoch war (Gen 6,15), also gerade noch Platz zwischen Wasseroberfläche und Himmel.
Correlated and Anticorrelated Binocular Disparity Modulate GABA+ and Glutamate/glutamine Concentrations in the Human Visual Cortex
Authors: Matuszewski Jacek , Alvarez Ivan , Clarke William T. , Parker Andrew J. , Bridge Holly , Ip I. Betina 
Published: February 2025

Binocular disparity is used for perception and action in three dimensions. Neurons in the primary visual cortex respond to binocular disparity in random dot patterns, even when the contrast is inverted between eyes (false depth cue). In contrast, neurons in the ventral stream largely cease to respond to false depth cues. This study evaluated whether GABAergic inhibition is involved in suppressing false depth cues in the human ventral visual cortex.We compared GABAergic inhibition (GABA+) and glutamatergic excitation (Glx) during the viewing of correlated and anticorrelated binocular disparity in 18 participants using single voxel proton magnetic-resonance spectroscopy (MRS). Measurements were taken from the early visual cortex (EVC) and the lateral occipital cortex (LO). Three visual conditions were presented per voxel location: correlated binocular disparity; anticorrelated binocular disparity; or a blank grey screen with a fixation cross. To identify differences in neurochemistry, GABA+ or Glx levels were compared across viewing conditions.In EVC, correlated disparity increased Glx over anticorrelated and rest conditions, also mirrored in the Glx/GABA+ ratio. In LO, anticorrelated disparity decreased GABA+ and increased Glx. The Glx/GABA+ ratio showed increased excitatory over inhibitory drive to anticorrelated disparity in LO. Glx during viewing of anticorrelation in LO was predictive of object-selective BOLD-activity in the same region.We provide evidence that early and ventral visual cortices change GABA+ and Glx concentrations during presentation of correlated and anticorrelated disparity, suggesting a contribution of cortical excitation and inhibition to disparity selectivity.Significance StatementThe visual system must correctly match elements from the left and right eye for proper reconstruction of binocular depth. At the earliest part of binocular processing, false matches can activate depth detectors, however, the activation to false matches is absent in the ventral visual stream. We tested whether GABAergic inhibition contributes to the suppression of false matches in the ventral stream by measuring GABAergic inhibition and glutamatergic excitation in the human visual cortex during presentation of correct and false matches. Correct matches increased excitation in response in the early visual cortex, and false matches increased excitation and decreased inhibition in the ventral visual cortex. These results suggest a role for excitation and inhibition in distinguishing depth cues for stereoscopic vision.
Analysis of the impact of different reheating methods on the flavour profile of venison dishes
Authors: Lu H.D. , Li P. , Wu H.R. , Lu Z.K. , Li F.L. , Zhong B. , Liu C. 
Published: February 2025

AbstractThis study investigates the flavour profile of volatile compounds in venison-based prepared food subjected to various reheating methods. Gas chromatography-ion mobility spectrometry (GC-IMS) and electronic nose technology were employed to detect and analyse the characteristic flavour of three types of venison prefabricated food samples, which underwent different reheating treatments. During the research, 41 distinct volatile compounds were identified from the venison prefabricated food samples. Following normalisation of ion peaks and three statistical analysis techniques, 21 types of volatile organic compounds (VOCs) were detected effectively from dishes reheated by air fryer. According to data analysed by the odour description database, the venison-containing dishes exhibited superior retention of wine and onion aromas upon reheating. The results of electronic nose detection indicated the presence of benzaldehyde, alcohols, aromatics, hydrocarbons, nitrogen oxides, and aliphatic aromatic substances in braised venison prefabricated vegetables; especially benzaldehyde and alcohols displayed similar aroma characteristics as detected by GC-IMS. Orthogonal partial least squares discriminant analysis (OPLS-DA) identified key variables contributing significantly to the volatile flavour profiles in venison prepared vegetables across different reheating methods: The main odourants were ethanol, undecane D, 1-propanol, ethyl acetate (acetic acid ethyl ester), 3-methylbutan-1-ol, n-pentanal, 6-methyl-5-hepten-2-one, 1-butanol, butanal, and other 30 compounds (VIP > 1).
An UPLC-MS/MS method for determination of karacoline in mice and its pharmacokinetics study
Authors: Huang Wenwen , Dong Xicheng , Lin Rong , Ma Jianshe 
Published: February 2025

AbstractIn this experiment, ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed to quantify karacoline in mouse plasma following both intravenous and oral administration, thereby elucidating the pharmacokinetic characteristics of karacoline in mice. The analytes were extracted from mouse plasma using acetonitrile for protein precipitation. Chromatographic separation was performed on an HSS T3 column via gradient elution, with the mobile phase consisting of methanol and 0.1% formic acid in water. Quantification of karacoline and the internal standard (IS) was achieved using multiple reaction monitoring (MRM) mode. Six mice received an intravenous (i.v.) injection of karacoline at a dose of 1 mg kg−1, while another six mice were administered karacoline orally (p.o.) at a dose of 5 mg kg−1. The calibration curve for karacoline in mouse plasma ranged from 1 ng mL−1 to 2,500 ng mL−1. The intra-day precision was within 10.4%, and the inter-day precision was within 13.0%. Accuracy ranged from 89.1% to 107.5%, with recovery rates between 77.6% and 88.2%. Matrix effects were observed within the range of 77.6%–107.4%. This method successfully estimated the pharmacokinetics of karacoline, and its bioavailability was determined to be 27.2%, these are preliminary studies that require verification on a larger group of animals.
The Safety and Protective Effects of Intravitreal Injection of Human Adipose-Derived Mesenchymal Stem Cells in a Rat Model of Retinal Ischemia/Reperfusion Injury
Authors: Hu Baiyu , Shu Jing , Fan Hanying , Xin Mei , Zeng Liuzhi 
Published: February 2025

Purpose: The purpose of this study was to evaluate the safety and protective effects of intravitreal injection of human adipose-derived mesenchymal stem cells (ADMSCs) in a rat model of retinal ischemia/reperfusion (I/R) injury induced by anterior chamber perfusion.

Methods: Two weeks after induction of I/R injury, rats received a single intravitreal injection of human ADMSCs at doses of 2×10⁴ cells or 5×10⁴ cells suspended in 3 μL saline. Control rats received 3 μL saline or no injection. Retinal and optic nerve changes were assessed at two weeks after injection using immunofluorescence, hematoxylin and eosin staining, toluidine blue staining, and polymerase chain reaction to evaluate inflammation-related and neurotrophic factors.

Results: Intravitreal injection of human ADMSCs significantly reduced the number of apoptotic retinal ganglion cells after I/R injury, preserved the ganglion cell layer, and increased expression of neurotrophic factors such as brain-derived neurotrophic factor and insulin-like growth factor 1. The high-dose group (receiving 5×10⁴ cells) demonstrated superior neuroprotective effects compared to the low-dose group (receiving 2×10⁴ cells) as evidenced by less retinal ganglion cell apoptosis. In addition, histopathological analysis revealed localized tissue remodeling and increased microglial infiltration, particularly in the low-dose group.

Conclusion: The safety of intravitreal human adipose-derived mesenchymal stem cell transplantation requires further investigation, particularly with regard to potential proliferative responses and their long-term effects. In addition, the optimal dosage of adipose-derived mesenchymal stem cells needs to be explored to balance therapeutic efficacy and minimize adverse outcomes. which was associated with structural retinal damage. In addition, the high-dose group exhibited a potential risk of inflammation or maladaptive changes.
Microbiological factors in osteoarthritis
Authors: Peretsmanas E. O. , Zar V. V. , Rukin Ya. A. , Kazyulina A. A. , Pakhlavonova A. D. 
Published: February 2025

Introduction Osteoarthritis (OA) is a common polyetiological disease of the musculoskeletal system, leading to disability. The condition can prevent a person from work, affect mental health, increasing mortality and affecting health care resources around the world as a current and future disease burden. OA had been considered an aseptic disease in the past and now the microbiological factor is viewed as one of the significant etiological aspects of the condition.The objective was to summarize the literature data on the role of microorganisms in the etiology and pathogenesis of osteoarthritis, including concomitant HIV infection.Material and methods The original literature search (2010 to 2023) was conducted on key resources including Scientific Electronic Library (www.elibrary.ru) and the National Library of Medicine (www.pubmed.org). Literature searches included both Russian and English studies reporting the effect of microbiological factors on the development of arthropathy.Results and discussion New, more advanced microbiological diagnostic methods have been used. There has been evidence of a variety of microorganisms including pathogenic and opportunistic pathogens in the absence of clinical and radiological signs of arthritis. This changes ideas about the etiology and pathogenesis of degenerative processes in the articular cartilage and necessitates a revision of treatment protocols for some joint diseases. Multicenter comprehensive studies of the microbiome of joint formations, blood and intestines are needed.Conclusions The presence of pathogenic microflora in the joint structures is evident in a significant number of observations. There is evidence of a local infectious process in the local cellular elements of osteochondral tissue in patients with previously diagnosed aseptic osteoarthritis. Intestinal microbiomes and the urogenital tract are most common sources of infection. A local influence of the immunodeficiency virus on the development of osteonecrotic processes in joint formations can be suggested in HIV patients.