bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two‐dimensional elastic distribution imaging of the sclera using acoustic radiation force optical coherence elastography
Authors: Luo Jiahui , Zhang Yubao , Ai Sizhu , Shi Gang , Han Xiao , Wang Yidi , Zhao Yanzhi , Yang Hongwei , Li Yingjie , He Xingdao 
Published: November 2023

AbstractThe scleral elasticity is closely related with many ocular diseases, but the relevant research is still insufficient. Here, we utilized optical coherence elastography to carefully study biomechanical properties of the sclera at different positions and under different intraocular pressures. Meanwhile, elastic wave velocity and Young's modulus of each position were obtained using a phase velocity algorithm. Accordingly, the two‐dimensional elasticity distribution image was achieved by mapping the Young's modulus values to the corresponding structure based on the relationship between the position and its Young's modulus. Therefore, elastic information in regions‐of‐interest can be read and compared directly from the scleral structure, indicating that our method may be a very useful tool to evaluate the elasticity of sclera and provide intuitive and reliable proof for diagnosis and research.
Rapid low‐cost hyperspectral imaging system for quantitative assessment of infantile hemangioma
Authors: Perkov Sergei , Vorobev Viktor , Kurochkin Maxim A. , Gorodkov Sergey , Gorin Dmitry 
Published: November 2023

AbstractHemangioma, the predominant benign tumor occurring in infancy, exhibits a wide range of prognoses and associated outcomes. The accurate determination of prognosis through noninvasive imaging modalities holds essential importance in enabling effective personalized treatment strategies and minimizing unnecessary surgical interventions for individual patients. The present study focuses on advancing the personalized prognosis of hemangioma by leveraging noninvasive optical sensing technologies by the development of a novel rapid hyperspectral sensor (image collection in 5 s, lateral resolution of 10 μm) that is capable of quantifying hemoglobin oxygenation and vascularization dynamics during the course of tumor evolution. We have developed a quantitative parameter for hemangioma assessment, that demonstrated agreement with the clinician's conclusion in 90% among all cases during clinical studies on six patients, who visited clinician from two to four times. The presented methodology has potential to be implemented as a supportive tool for accurate hemangioma diagnostics in clinics.
Accounting reporting complexity, audit engagement partner mandatory rotation, and audit quality
Authors: Chen Clement , Liu Zhenfeng , Tang Wenye , Tuo Ling 
Published: November 2023

AbstractThis paper investigates the influence of a firm's accounting reporting complexity (ARC) on financial statement audit quality. We predict and find that there is a non‐linear relationship between a firm's ARC and audit quality. Specifically, a more complex accounting environment—measured by ARC—leads to higher quality audits, but this effect diminishes when ARC continues to increase. Further analyses reveal that the effect is more salient among client firms that do not purchase non‐audit services (NAS). We also examine whether ARC affects audit quality in the circumstance of mandatory audit partner rotation. Empirical results show a moderating effect of ARC on the negative influence of audit partner rotation on audit quality. Our study extends the literature by illustrating how a firm's ARC influences audit quality in a special manner.
Does uncertainty in the banking sector slow down corporate performance?
Authors: Huynh Japan 
Published: November 2023

AbstractThe paper explores the effects of banking uncertainty on corporate performance. Utilizing data from 2007 to 2022 in Vietnam and a comprehensive methodology to assess the performance of the sampled firms, our analysis reveals a detrimental impact of banking uncertainty on firm performance. Specifically, heightened uncertainty leads to diminished profitability ratios, reduced operational efficiency, constrained growth potential, and a decline in market valuation for firms. Our findings also indicate that firms may accumulate higher levels of liquidity in response to amplified uncertainty. Additionally, the subdued performance of firms attributable to banking uncertainty is more pronounced among those burdened with elevated bank debts. Interestingly, while the average impact of banking uncertainty on firm performance appears to be weak as a whole, this impact becomes notably magnified for firms maintaining greater credit relationships with banks. Our results are robust to different model specifications, variables, and subsamples. Overall, we provide evidence that banking uncertainty has important implications for corporate performance.
Children of parents with depression or anxiety: Long‐term follow‐up, causality and resilience
Authors: Larsson Henrik 
Published: November 2023

AbstractThree papers in the December issue (2023) of JCPP Advances focus on children of parents with depression or anxiety. They highlight the value of using prospective longitudinal data to improve the understanding about the development of children of parents with depression or anxiety from early childhood to young adulthood. They contribute to an advanced understanding of long‐term outcomes, causality and resilience for children of parents with depression or anxiety.
An evidence‐based teaching approach enhances student learning of periodontal disease pathogenesis
Authors: Tebcherany Houda , Khocht Ahmed 
Published: November 2023

AbstractPurpose/objectivesTo evaluate the effects of implementing an evidence‐based teaching approach (EBTA) in a traditional dental curriculum course on predoctoral dental students’ knowledge and attitudes about evidence‐based dentistry, and to determine its benefit on enhancing students’ academic performance.MethodsFundamentals of periodontics for first‐year dental students (D1,n = 100) span a period of 12 weeks. In the first 6 weeks, we teach the basic principles of periodontal disease pathogenesis and introduce the concepts of EBTA (basics of research study design, statistical principles, literature search, and critically analyzing the evidence) without active implementation. In the second 6 weeks, we build on the initial knowledge of periodontal disease pathogenesis and actively implement EBTA activities to enhance the learning of the course content. Pre‐ and post‐EBTA implementation, students completed a validated survey assessing students’ knowledge, attitudes, access of evidence, and confidence related to evidence‐based dentistry. Midterm and final grades were used to assess student academic performance.ResultsPost‐EBTA implementation survey responses showed: significant increase in students’ knowledge regarding critical appraisal of the literature (p = 0.0001), significant improvement in students’ attitudes about evidence‐based dentistry (p = 0.0001), significant increase in students’ frequency of accessing evidence from various sources (p = 0.01), and significant increase in students’ confidence in evaluating various aspects of a published research report (p = 0.009). Post‐EBTA final grade scores were significantly higher than pre‐EBTA midterm grade scores (p = 0.0001).ConclusionsIntegrating an EBTA within a traditional dental curriculum course improves students’ knowledge and attitudes about evidence‐based dentistry as well as enhances students’ academic performance.
A preliminary study on the dynamics of serum color in perspective to hemoglobin and bilirubin in indigenous sheep of Pakistan
Authors: Idris Musadiq , Farooq Umer , Rashid Haroon , Lashari Mushtaq Hussain , Riaz Umair , Khan Musarrat Abbas , Fatima Iram , Sajjad Hafsa , Qayyum Sumama , Ahmad Maqsood , Awais Muhammad , Sajjad Nouman , Perveen Zobia 
Published: November 2023

AbstractThe present study is the first of its kind being reported for an indigenous sheep breed of Pakistan with objectives to (a) assess the diagnostic efficacy of a human‐based “serum hemolysis reference palette” for sheep serum, (b) deduce normal reference intervals (RIs) for hemoglobin (Hb) and bilirubin, and (c) devise a novel serum color chart for on‐field estimation of Hb and bilirubin through color matching of sheep serum. Apparently, healthy Sipli sheep (n = 130) were bled twice attaining whole blood and serum samples (n = 260). The study animals were grouped on the basis of gender, that is, males (n = 51) and females (n = 79) and age, that is, G1 (up till 1 year) (n = 41), G2 (from 1 to 2 years) (n = 46), and G3 (from 2 to 3 years) (n = 43). None of the 260 serum samples of the sheep matched the color given on the human‐based “hemolysis reference palette.” The G1 animals revealed marked variation in their serum color. Hence, on the basis of RIs, the serum samples (n = 178) of adult sheep (G2 and G3) showing three main color bands were used in devising a novel serum Hb and bilirubin estimation chart for adult sheep serum. In conclusion, the human‐based serum hemolysis palette is not valid for sheep serum. The RIs attained in the study could provide a yardstick for assessment of health in indigenous sheep breeds whereas the serum color chart may be of value in estimating Hb and bilirubin in a quick, reliable, and cheaper way for the resource‐poor settings of the world.
Transcriptional regulation of esophageal, intestinal, and branchial solute transporters by salinity, growth hormone, and cortisol in Atlantic salmon
Authors: Breves Jason P. , Runiewicz Ellie R. , Richardson Sierra G. , Bradley Serena E. , Hall Daniel J. , McCormick Stephen D. 
Published: November 2023

AbstractIn marine habitats, Atlantic salmon (Salmo salar) imbibe seawater (SW) to replace body water that is passively lost to the ambient environment. By desalinating consumed SW, the esophagus enables solute‐linked water absorption across the intestinal epithelium. The processes underlying esophageal desalination in salmon and their hormonal regulation during smoltification and following SW exposure are unresolved. To address this, we considered whether two Na+/H+ exchangers (Nhe2 and −3) expressed in the esophagus contribute to the uptake of Na+ from lumenal SW. There were no seasonal changes in esophageal nhe2 or −3 expression during smoltification; however, nhe3 increased following 48 h of SW exposure in May. Esophageal nhe2, −3, and growth hormone receptor b1 were elevated in smolts acclimated to SW for 2.5 weeks. Treatment with cortisol stimulated branchial Na+/K+‐ATPase (Nka) activity, and Na+/K+/2Cl− cotransporter 1 (nkcc1), cystic fibrosis transmembrane regulator 1 (cftr1), and nka‐α1b expression. Esophageal nhe2, but not nhe3 expression, was stimulated by cortisol. In anterior intestine, cortisol stimulated nkcc2, cftr2, and nka‐α1b. Our findings indicate that salinity stimulates esophageal nhe2 and −3, and that cortisol coordinates the expression of esophageal, intestinal, and branchial solute transporters to support the SW adaptability of Atlantic salmon.
Exploring the training needs of inherited cardiac conditions (ICC) nurses: Elucidating role boundaries and competencies for practice in the genomics era
Authors: Braddel Amy , Watson Melanie 
Published: November 2023

AbstractNurses represent the largest professional group within the National Health Service (NHS) and are therefore central to the successful integration of mainstreaming genomics into routine healthcare. Inherited cardiac conditions (ICC) nurse roles have been developed in recent years to streamline the care for patients and families affected by an ICC. Like many nurse specialists, ICC nurses' prior exposure to genomics and the wider implications surrounding inherited conditions is limited. The aim of the study was to explore the education needs and support required for ICC nurses to fulfill their role within the genomic medicine era. A convenience sampling approach was adopted to invite ICC nurses working within various NHS Trusts across the United Kingdom to take part. Semi‐structured interviews were conducted with ICC nurses (n = 8), which were recorded, transcribed, coded, and analyzed using an inductive thematic analysis approach. Analysis of interview data highlighted four core themes, which were transferrable core competencies; managing genomic information; mixed‐modality learning; defining multidisciplinary team boundaries. The study highlights areas for further training and demonstrates the importance of defining competencies and role boundaries within ICC services. The ICC nurses identified the limits of their practice and the complementary role of genetic counselors, indicating the need for both professions within the ICC service and proposing implications for practice.
The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease
Authors: Abdul‐Rahman Toufik , Ghosh Shankhaneel , Kalmanovich Jacob B. , Awuah Andrew Wireko , Zivcevska Marija , Khalifa Samar , Bassey Esther Edet , Ali Namarig Alnil , Ferreira Matheus Mendes dos Santos , Umar Tungki Pratama , Garg Neil , Nweze Victor Nnanna , Inturu Venkata Sai Sulekhya , Abdelwahab Maya Magdy , Kurian Sneha , Alexiou Athanasios , Alfaleh Mohammed , Alqurashi Thamer M. A. , Ashraf Ghulam Md 
Published: November 2023

AbstractMembrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles. This process is required for cells to mature and function properly, allowing them to adapt to their surroundings. The retromer complex is a complex composed of nexin proteins and peptides that play a vital role in the endosomal pathway of membrane trafficking. In humans, any interference in normal membrane trafficking or retromer complex can cause profound changes such as those seen in neurodegenerative disorders such as Alzheimer's and Parkinson's. Several studies have explored the potential causative mechanisms in developing both disease processes; however, the role of retromer trafficking in their pathogenesis is becoming increasingly significant with promising therapeutic applications. This manuscript describes the processes involved in membrane transport and the roles of the retromer in the onset and progression of Alzheimer's and Parkinson's. Moreover, we will also explore how these aberrant mechanisms may serve as possible avenues for treatment development in both diseases and the prospect of its future application.
Recent advances for treatment of upper gastrointestinal malignancy
Authors: Sestito Michael , Pratt Hillary , Schmidt Carl , Thomay Alan 
Published: November 2023

AbstractRecent prospective trials for esophageal cancer, gastric cancer, and gastrointestinal stromal tumor (GIST) are encouraging. This manuscript reviews selected recently published studies. Not surprisingly, immunotherapy dominates the current clinical trial landscape. However, targeted biologic therapies and standard chemotherapy remain critical to the treatment of gastric and esophageal cancer while imatinib remains the backbone for advanced or metastatic GISTs. For all three cancers, surgical resection remains important when intent of treatment is potential cure.
Immediate diagnosis of cutaneous metastases with optical coherence tomography, line‐field confocal optical coherence tomography and dermoscopy: A case series
Authors: Hobelsberger Sarah , Gellrich Frank Friedrich , Laske Jörg , Meier Friedegund , Beissert Stefan , Steininger Julian 
Published: November 2023

AbstractBackgroundCutaneous metastases (CM) are a frequent finding in the follow‐up of malignant tumours.ObjectivesCM were examined with dermoscopy, optical coherence tomography (OCT), dynamic OCT and line‐field confocal OCT (LC‐OCT) to describe common findings.MethodsIn the University Hospital Carl Gustav Carus Dresden, Germany, 18 patients with 61 CM were examined with dermoscopy. CM (n = 43, 31 melanoma metastases, two metastases of renal carcinoma, five metastases of cutaneous squamous cell carcinoma and five metastases of pleomorphic dermal sarcoma) were examined with OCT (VivoSight® Michelson Diagnostics). Additional 18 melanoma metastases were examined with LC‐OCT (deepLive™; Damae Medical).ResultsCM were localized on the head, trunk, neck and limbs. Dermoscopy patterns were angioma‐like, nevus‐like nonglobular, nevus‐like globular, blue nevus‐like and unspecific. CM showed an ulceration, hyperkeratosis with increased entrance signal and disturbed architecture of the epidermis in OCT. In deeper metastases, the dermoepidermal junction (DEJ) was normal; in most cases it was disturbed. CM were visible as subepidermal hyporeflective roundish area, with septae, with either clear margin and shadowing or blurred margin. DOCT showed dot, coiled, serpiginous and branched vessels; there was a disarray in size and distribution and vessels were converging on the centre of the metastasis. In LC‐OCT, CM showed enhanced entrance signal and disturbed architecture of a thinned epidermis, ulceration, atypical honeycomb or cobblestone pattern as well as a broken DEJ. In the dermis, a hyporeflective roundish area with clusters of hyporeflective cells with septae, clear margin and clefting or blurred margin was visible; the hyporeflective area was surrounded by bundles of connective tissue. Subepidermal vessels differentiated in size and distribution. Inflammatory, dendritic and pagetoid cells were visible.ConclusionsOCT and LC‐OCT may be useful tools for immediate diagnosis, localization of CM and monitoring under treatment in addition to conventional methods like ultrasound and histopathology.
Stimulation Crosstalk Between Cochlear And Vestibular Spaces During Cochlear Electrical Stimulation
Authors: de Miguel Ángel Ramos , Rodriguez Montesdeoca Isaura , Falcón González Juan Carlos , Borkoski Barreiro Silvia , Zarowski Andrzej , Sluydts Morgana , Falcón Benitez Nadia , Ramos Macias Angel 
Published: November 2023

ObjectivesPossible beneficial “crosstalk” during cochlear implant stimulation on otolith end organs has been hypothesized. The aim of this case–control study is to analyze the effect of electrical cochlear stimulation on the vestibule (otolith end‐organ), when using a cochleo‐vestibular implant, comparing vestibular stimulation (VI) and cochlear stimulation (CI).MethodsFour patients with bilateral vestibulopathy were included. A double electrode array research implant was implanted in all cases. Dynamic Gait Index (DGI), VOR gain measured by using vestibular head impulse test (vHIT), acoustic cervical myogenic responses (cVEMP) recordings, and electrical cVEMP were used in all cases. Trans‐impedance Matrix (TIM) analysis was used to evaluate the current flow from the cochlea to the vestibule.ResultsWhile patients did not have any clinical vestibular improvement with the CI stimulation alone, gait metrics of the patients revealed improvement when the vestibular electrode was stimulated. The average improvement in the DGI was 38% when the vestibular implant was activated, returning to the normal range in all cases. Our findings suggest that any current flow from the cochlear space to the otolith organs was insufficient for effective cross‐stimulation. The functional results correlated with the data obtained in TIM analysis, confirming that there is no current flow from the cochlea to the vestibule.ConclusionThe only way to produce effective electrical otolith end‐organ stimulation, demonstrated with this research implant, is by direct electrical stimulation of the otolith end organs. No effective cross‐stimulation was found from cochlear electrode stimulation.Level of Evidence4 Laryngoscope, 134:2349–2355, 2024
Effects of nutrient addition on the composition and chemical characteristics of soil dissolved organic matter in a desert steppe in northern China
Authors: Liu Bingqing , Wu Rongjie , Xue Bin , Gao Ruili , An Hui , Liu Lichao , Ndzana George Martial , Du Lingtong , Kamran Muhammad 
Published: November 2023

AbstractDissolved organic matter (DOM) plays a critical role in ecosystem function and productivity, particularly in carbon (C) cycling in grassland ecosystems. However, changes in the structural complexity of DOM in a desert steppe following long‐term treatment with nitrogen (N) and phosphorus (P) remain unclear; this limits our understanding of the nutrient‐related soil C cycle in a desert steppe. In the present study, soil experiments were conducted in the 0–10 cm soil layer of a desert steppe in northern China from 2017 to 2021, and four treatments were established: P, N, N + P (NP), and no nutrient addition (CK). The content and chemical composition of soil DOM were determined by ultraviolet–visible absorbance, fluorescence, and Fourier transform infrared spectroscopy. Compared to CK treatment, nutrient addition increased soil DOM content by 2.86%–53.84%. NP addition increased the average molecular weight, aromaticity, and humification degree of soil DOM. The DOM source was attributed to the combination of foreign and local sources. Fluorescent components of the DOM samples were mainly proteins and humic acids; the humic acid content decreased after N addition and increased after P and NP addition. Nutrient availability and pH were the key factors affecting the changes in the source and average molecular weight of the DOM, respectively. The soil organic matter content was significantly positively correlated with the humification index (r = 0.96). These results imply that nutrient addition accelerates the accumulation of DOM and influences its structural complexity; this potentially benefits soil C sequestration in a desert steppe.
Bacterial biogeography of the Indian Ocean
Authors: Brock Melissa L. , Larkin Alyse A. , Raes Eric J. , Martiny Adam C. 
Published: November 2023

AbstractHistorically, our understanding of bacterial ecology in the Indian Ocean has been limited to regional studies that place emphasis on community structure and function within oxygen‐minimum zones. Thus, bacterial community dynamics across the wider Indian Ocean are largely undescribed. As part of Bio‐GO‐SHIP, we sequenced the 16S rRNA gene from 465 samples collected on sections I07N and I09N. We found that (1) there were 23 distinct bioregions within the Indian Ocean, (2) the southeastern gyre had the largest gradient in bacterial alpha‐diversity, (3) the Indian Ocean surface microbiome was primarily composed of a core set of taxa, and (4) bioregions were characterized by transitions in physical and geochemical conditions. Overall, we showed that bacterial community structure spatially delineated the surface Indian Ocean and that these microbially defined regions were reflective of subtle ocean physical and geochemical gradients. Therefore, incorporating metrics of in situ microbial communities into marine ecological regions traditionally defined by remote sensing will improve our ability to delineate warm, oligotrophic regions.
Advances in Stimuli‐Responsive Chitosan Hydrogels for Drug Delivery Systems
Authors: Xia Yuhan , Ma Zhiyuan , Wu Xuechen , Wei Huidan , Zhang Han , Li Guang , Qian Yuqi , Shahriari‐Khalaji Mina , Hou Kai , Cao Ran , Zhu Meifang 
Published: November 2023

AbstractSustainable and controllable drug transport is one of the most efficient ways of disease treatment. Due to high biocompatibility, good biodegradability, and low costs, chitosan and its derivatives are widely used in biomedical fields. Specifically, chitosan hydrogel enables drugs to pass through biological barriers because of their abundant amino and hydroxyl groups that can interact with human tissues. Moreover, the multi‐responsive nature (pH, temperature, ions strength, and magnetic field, etc.) of chitosan hydrogels makes precise drug release a possibility. Here, the synthesis methods, modification strategies, stimuli‐responsive mechanisms of chitosan‐based hydrogels, and their recent progress in drug delivery are summarized. Chitosan hydrogels that carry and release drugs through subcutaneous (dealing with wound dressing), oral (dealing with gastrointestinal tract), and facial (dealing with ophthalmic, ear, and brain) are reviewed. Finally, challenges toward clinic application and the future prospects of stimuli‐responsive chitosan‐based hydrogels are indicated.