bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health effects associated with exposure to intimate partner violence against women and childhood sexual abuse: a Burden of Proof study
Authors: Spencer Cory N. , Khalil Mariam , Herbert Molly , Aravkin Aleksandr Y. , Arrieta Alejandra , Baeza María Jose , Bustreo Flavia , Cagney Jack , Calderon-Anyosa Renzo J. C. , Carr Sinclair , Chandan Jaidev Kaur , Coll Carolina V. N. , de Andrade Fabiana Martins Dias , de Andrade Gisele N. , Debure Alexandra N. , Flor Luisa S. , Hammond Ben , Hay Simon I. , Knaul Felicia N. , Lim Rachel Q. H. , McLaughlin Susan A. , Minhas Sonica , Mohr Jasleen K. , Mullany Erin C. , Murray Christopher J. L. , O’Connell Erin M. , Patwardhan Vedavati , Reinach Sofia , Scott Dalton , Sorenson Reed J. D. , Stein Caroline , Stöckl Heidi , Twalibu Aisha , Vasconcelos Nádia , Zheng Peng , Metheny Nicholas , Chandan Joht Singh , Gakidou Emmanuela 
Published: December 2023

AbstractThe health impacts of intimate partner violence against women and childhood sexual abuse are not fully understood. Here we conducted a systematic review by comprehensively searching seven electronic databases for literature on intimate partner violence-associated and childhood sexual abuse-associated health effects. Following the burden of proof methodology, we evaluated the evidence strength linking intimate partner violence and/or childhood sexual abuse to health outcomes supported by at least three studies. Results indicated a moderate association of intimate partner violence with major depressive disorder and with maternal abortion and miscarriage (63% and 35% increased risk, respectively). HIV/AIDS, anxiety disorders and self-harm exhibited weak associations with intimate partner violence. Fifteen outcomes were evaluated for their relationship to childhood sexual abuse, which was shown to be moderately associated with alcohol use disorders and with self-harm (45% and 35% increased risk, respectively). Associations between childhood sexual abuse and 11 additional health outcomes, such as asthma and type 2 diabetes mellitus, were found to be weak. Although our understanding remains limited by data scarcity, these health impacts are larger in magnitude and more extensive than previously reported. Renewed efforts on violence prevention and evidence-based approaches that promote healing and ensure access to care are necessary.
Effects of therapeutic exercise on the motor function of adults with Down syndrome: a systematic review and meta-analysis
Authors: Méndez-Martínez Melanie , Rodríguez-Grande Eliana-Isabel 
Published: December 2023

AbstractTherapeutic exercise exerts positive effects by mitigating or reducing the motor or cognitive changes that people with Down syndrome undergo throughout their life. There are no updated systematic reviews that integrate the evidence available in a way that facilitates decision-making for physical rehabilitation teams. This study therefore aimed to consolidate the information available and compare the effects of different types of physical exercise on the motor function of adults with DS. We conducted a systematic review and meta-analysis of randomized clinical trials and quasi-experimental studies. The literature search was performed between January 2023 and February 2023 using the PubMed, SCIELO, Epistemonikos, and Lilacs databases. Studies were selected according to pre-determined inclusion and exclusion criteria. The risk-of-bias assessment was performed using the risk-of-bias rating tool for randomized clinical trial (RoB) and the risk of bias of non-randomized comparative studies was assessed using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Risk-of-bias assessment and meta-analyses were performed using the RevMan software package. Sixteen studies met the eligibility criteria for the qualitative synthesis and 4 were included in the meta-analyses. Combined exercise significantly increased muscle strength both in the upper limbs (SMD = 0.74 [95% CI 0.25–1.22]) and lower limbs (SMD = 0.56[95% CI 0.08–1.04]). Aerobic exercise improved spatiotemporal gait parameters. Aerobic exercise showed significant improvements in dynamic balance while combined exercise significantly increased dynamic and static balance. The certainty of the evidence was low to moderate for all outcomes. There was low and moderate certainty of evidence for the outcomes proposed in this review. However, therapeutic exercise could be effective in improving muscle strength and gait functionality.
Long-term visual outcomes in pachychoroid spectrum diseases and its associating factors of eyes with chronic central serous chorioretinopathy
Authors: Azuma Keiko , Tanaka Nobuya , Aoki Shuichiro , Kitamoto Kohdai , Ueda Kohei , Inoue Tatsuya , Obata Ryo 
Published: December 2023

AbstractTo analyze the long-term visual outcomes of pachychoroid spectrum diseases (PSD). Retrospective study. We reviewed the medical charts of consecutive patients with PSD, including focal choroidal excavation (FCE), pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC), and pachychoroid neovasculopathy (PNV). The patients initially visited the Tokyo University Hospital from January 2008 to March 2021. Survival analyses were performed, in which loss of vision was defined as visual acuity (VA) of 0.2 logarithm of minimal angle of resolution (logMAR) or worse, 0.5 logMAR or worse, or VA worsening by 0.3 logMAR or greater. Moreover, we further investigated factors associated with visual prognosis, particularly in the CSC group. A total of 741 eyes of 638 patients were included in this analysis. The CSC or PNV group showed significantly worse visual prognosis than the FCE&PPE group for VA to 0.2 logMAR or worse (P = 0.0117 or 0.0001, respectively) and for VA worsening by 0.3 logMAR or greater (P = 0.0283 or 0.0037, respectively). In the CSC group, unlike age, sex, or treatment history, the accumulative duration of subfoveal fluid existence ≥ 12 months (continuous or intermittent) was significantly associated with visual prognosis (P < 0.0001). Among PSD, CSC and PNV were associated with a higher risk of vision loss in the long term than FCE and PPE. The duration of subretinal fluid existence was identified as a significant factor affecting long-term visual outcomes in CSC.
Severity of error in hierarchical datasets
Authors: Srivastava Satwik , Mishra Deepak 
Published: December 2023

AbstractClassification tasks today, especially for the medical domain, use datasets which are often hierarchical. These tasks are approached using methods that consider the class taxonomy for predicting a label. The classifiers are gradually becoming increasingly accurate over the complex datasets. While increasing accuracy is a good way to judge a model, in high-risk applications, it needs to be ensured that even if the model makes a mistake, it does not bear a severe consequence. This work explores the concept of severity of an error and extends it to the medical domain. Further, it aims to point out that accuracy or AUROC alone are not sufficient metrics to decide the performance of a model in a setting where a misclassification will incur a severe cost. Various approaches to reduce severity for classification models are compared and evaluated in this work, which indicate that while many of them might be suited for a traditional image classification setting, there is a need for techniques tailored toward tasks and settings of medical domain to push artificial intelligence in healthcare to a deployable state.
Development and application of fluorine doped bismuth vanadate reduced graphene oxide Nafion composite electrode as an electrochemical sensor for 4-chlorophenol
Authors: Ghorbannejad Bahareh , Mahjoub Alireza , Dalir Nima 
Published: December 2023

AbstractThis study describes the synthesis of fluorine-doped bismuth vanadate (F0.1BiVO4) and its composite with graphene oxide (GO) to improve charge transport properties. Based on the structural and morphological analysis such as X-Ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and RAMAN the composite of F0.1BiVO4/r-GO/Nafion was successfully prepared with no filth. It was used to selectively detect the environmental contaminant 4-chlorophenol (4-CP) on a modified glassy carbon electrode (GCE). The electron channeling ability of reduced graphene oxide (r-GO) with F0.1BiVO4 yielded a great electrochemical response (ER) in cyclic voltammetry compared to pure GCE and other modified electrodes. The differential pulse voltammetry response of 4-CP was highly sensitive with the detection of limit (LOD) of 0.56 nM and a wide linear response of 0.77–45.0 nM. Fluorine doping, in particular, was able to affect the crystal growth of BiVO4, which was the primary cause of the aforementioned improvement. On the other hand, r-GO acts as an electron bridge to improve charge transfer between electrolytes and F-BiVO4 due to its high electron transport rate. These results demonstrate the effectiveness of F0.1BiVO4/r-GO/Nafion/GCE for the electrochemical detection of 4-CP.
Quantum DFT studies on the drug delivery of favipiravir using pristine and functionalized chitosan nanoparticles
Authors: Ataei Sheyda , Nemati-Kande Ebrahim , Bahrami Aidin 
Published: December 2023

AbstractConsidering the spread of the COVID-19 pandemic, finding new drugs along with the development of effective drug delivery methods can help in the treatment of this disease. For this reason, in this research work, the possibility of drug-delivery of Favipiravir (FP), one of the drugs approved in the treatment of COVID-19, by pristine chitosan (Chit) nanoparticles (NP), and functionalized chitosan nanoparticles with N-acylate, N-methyl, O-acetyl, and Oxazoline functional groups was studied using quantum mechanical DFT methods at B3LYP-D3(BJ)/6-311 + g(d,p) theoretical level in water medium. The QTAIM, NBO, DOS, frontier orbital, conceptual-DFT indices, and non-covalent interaction analysis were further implemented to investigate the possible interactions between FP and Chit NPs. The results show that the adsorption of FP on Chit NPs is done through the creation of hydrogen bonds, and the highest absorption energy of − 18.15 kcal/mol between pristine chitosan and FP. In the case of all functionalized Chit NPs, a decrease in the absorption energy is observed, which is more noticeable in the case of N-acylated and O-acetyl functionalize Chit NPs, and indicates the weakening of the van der Waals interactions for these cases. Considering the compatibility of Chit NPs with the human body and their non-toxicity, as well as the fact that factors such as pH, solubility, the ionic strength, and so on can be adjusted to control the release rate using the functionalized Chit NPs, it seems that the results of this work can be a comprehensive guide to design the drug delivery methods of FP drug using Chit NPs, to reduce the symptoms of COVID-19 disease.
Risk factors for pharyngalgia and xerostomia undergoing supraglottic jet oxygenation and ventilation in gastrointestinal endoscopy: a retrospective study
Authors: Xie Ping , Wu Zhiyun , Zha Benjun , Xu Li , Shen Shanyi , Zhuang Haibin , Wei Huafeng 
Published: December 2023

AbstractSupraglottic jet oxygenation/ventilation (SJOV) can reduce hypoxemia in sedated endoscopy but may increase minor side effects like pharyngalgia and xerostomia. This study aimed to identify risk factors for pharyngalgia/xerostomia with SJOV during gastrointestinal endoscopy. From January 1 to December 31, 2021, 5313 patients with propofol sedation and SJOV underwent gastrointestinal endoscopy or removal of gastrointestinal polyps was analyzed retrospectively. Data included patient characteristics, operation details, postoperative adverse events, and potential risk factors for postoperative adverse events. Parameters considered as potential risk factors were identified based on study results published previously and based on the researcher’s idea and clinical experience. The patient factors and the incidence of pharyngalgia/xerostomia at 30 min post-procedure were assessed. Descriptive statistics were calculated using SPSS software. Evaluation potential risk factors using univariate and multivariate logistic regression. Pharyngalgia/xerostomia occurred in 18.7% of patients at 30 min after procedure. A multivariable analysis showed that procedure time and pharyngalgia/xerostomia within 2 weeks were independent risk factors. Procedure time had the strongest association with postoperative pharyngalgia/xerostomia (OR, 8.09 [95% CI, 4.197–6.312]). No factors were significantly associated with hypoxemia risk (1.7% incidence). There were no barotrauma or other serious morbidity or mortality. Procedure duration and recent pharyngalgia/xerostomia increased risk of pharyngalgia/xerostomia with SJOV during endoscopy. Limiting SJOV duration may reduce side effects in susceptible patients. No predictors of hypoxemia were identified.
Biaxial tensile behavior of stainless steel 316L manufactured by selective laser melting
Authors: Wang Hao , Shu Xiaoyong , Zhao Jianping , Alexandrov I. V. 
Published: December 2023

AbstractIn this study, miniaturized cruciform biaxial tensile specimens were optimized by finite element simulation software Ansys to vary five geometric parameters. The optimized specimens were utilized to characterize the biaxial tensile properties of 316L stainless steel fabricated through selective laser melting (SLM), with the two loading directions being vertical (X) and parallel (Y) to the building direction. It was discovered that at load ratios of 4:2 and 2:4, the yield strengths along X and Y orientations reached their respective maxima. By comparing the experimentally obtained yield loci against predictions by theoretical criteria including Mises, Hill48 and Hosford, it was found that the Hill48 anisotropic criterion corresponded most closely with the experimental results, while the other two criteria exhibited considerably larger deviations. Therefore, Hill48 was concluded to most accurately describe the yielding behaviors of SLM 316L under complex loading conditions.
A bibliometric analysis of the gender gap in the authorship of leading medical journals
Authors: Brück Oscar 
Published: December 2023

Abstract
Background
Monitoring gender representation is critical to achieve diversity and equity in academia. One way to evaluate gender representation in academia is to examine the authorship of research publications. This study sought to determine the gender of first and senior authors of articles in leading medical journals and assess trends in the gender gap over time.

Methods
We gather bibliometric data on original research articles (n = 10,558) published in 2010–2019 in five leading medical journals to audit publication and citation frequency by gender. We explored their association with scientific fields, geographical regions, journals, and collaboration scope.

Results
We show that there are fewer women as senior (24.8%) than leading authors (34.5%, p < 0.001). The proportion of women varied by country with 9.1% last authors from Austria, 0.9% from Japan, and 0.0% from South Korea. The gender gap decreased longitudinally and faster for the last (−24.0 articles/year, p < 0.001) than first authors (−14.5 articles/year, p = 0.024) with pronounced country-specific variability. We also demonstrate that usage of research keywords varied by gender, partly accounting for the difference in citation counts.

Conclusions
In summary, gender representation has increased, although with country-specific variability. The study frame can be easily applied to any journal and time period to monitor changes in gender representation in science.
Einstellungen von Hausärzt:innen und Medizinischen
Fachangestellten zur Delegation ärztlicher Leistungen –
Ergebnisse einer Befragung in Berlin, Brandenburg und
Thüringen
Authors: Wolf Florian , Krause Markus , Meißner Franziska , Rost Liliana , Bleidorn Jutta , Dierks Marius Tibor , Kuschick Doreen , Kuempel Lisa , Toutaoui Kahina , Riens Burgi , Schmidt Konrad , Heintze Christoph , Döpfmer Susanne 
Published: December 2023

Zusammenfassung
Einleitung Die Übertragung von hausärztlichen Aufgaben und
Verantwortlichkeiten an Medizinische Fachangestellte (MFA) kann zur
Sicherstellung der Primärversorgung in Deutschland beitragen. Das Ziel
der Studie ist die Erfassung und Analyse von Einstellungen und Vorgehensweisen
von Hausärzt:innen und MFA zur Delegation ärztlicher Aufgaben
und Tätigkeiten.
Methodik Allen KV-gelisteten Hausärzt:innen in Thüringen,
Berlin und Brandenburg (N=5.516) sowie deren MFA wurde ein selbst
konzipierter, pilotierter Fragebogen zugesandt. Die Teilnehmer:innen sollten
angeben, welche ärztlichen Tätigkeiten bereits
übertragen bzw. übernommen werden und bei welchen
Anlässen weitere Delegationen vorstellbar wären.
Ergebnisse Es nahmen 890 Ärzt:innen (Rücklaufrate:
16,1%) und 566 MFA an der schriftlichen Befragung teil. Die
Teilnehmer:innen waren überwiegend weiblich und zumeist im
(groß-)städtischen Raum tätig. Zahlreiche
Tätigkeiten, wie z. B. Anamnese, Triage, DMP-Kontrollen,
Impfungen und Hausbesuche, werden bereits delegiert. Die Bereitschaft zur
Übertragung bzw. Übernahme weiterer Aufgaben (z. B.
Folgeverordnung von Rezepten und Überweisungen, eigenständige
Übernahme von einfachen Konsultationen, Erforderlichkeit eines
Arztgespräches einschätzen) ist hoch.
Schlussfolgerung Die Befragung zeigte eine hohe Bereitschaft beider
Berufsgruppen zur Delegation ärztlicher Tätigkeiten an MFA. Eine
Ausweitung scheint unter bestimmten Voraussetzungen möglich. Bereits
heute werden viele Tätigkeiten in hausärztlichen Praxen
delegiert. Unsere Befragung gibt Hinweise auf weitere
Übertragungsmöglichkeiten, die teilweise über die
Delegationsvereinbarung hinausgehen.
Zerebrale Mikroangiopathie: Fortschritte im Verständnis der
Pathophysiologie
Authors: Henneicke Solveig , Meuth Sven Günther , Schreiber Stefanie 
Published: December 2023

ZusammenfassungDie sporadische zerebrale Mikroangiopathie umfasst altersabhängige
Veränderungen der kleinen Hirngefäße, die durch das
Vorliegen vaskulärer Risikofaktoren beschleunigt werden. Die
mikrovaskulären Wandveränderungen entwickeln sich eher langsam,
mit möglichem Beginn bereits in der mittleren Lebensphase –
über Dekaden – und zeigen einen stadienhaften Verlauf. Dieser
wird durch eine Aktivierung von Zellen der neurovaskulären Einheit, wie
Endothel und Perizyten, induziert und setzt sich dann über eine
Blut-Hirn-Schranken-Störung, den Umbau der extrazellulären
Matrix und Neuroinflammation zu den Spätstadien aus Blutungen,
synaptischer und neuronaler Dysfunktion fort. Begleitend kommt es bereits
früh zu Störungen der perivaskulären Drainage von
neurotoxischen Substanzen und deren Akkumulation im Hirngewebe. Die Diagnose der
Mikroangiopathie erfolgt allgemein im Wesentlichen anhand der “Standards
for Reporting Vascular Changes on Neuroimaging 2” in der
Magnetresonanztomographie, und die der zerebralen Amyloidangiopathie im
Speziellen anhand der neuen Boston-Version-2.0 Kriterien. Klinisch kann die
Mikroangiopathie asymptomatisch verlaufen oder sich in einem sehr heterogenen
phänotypischen Spektrum manifestieren. Kognitive Defizite und
Schlaganfallsymptome sind hier, je nach Kohorte, sicher die häufigsten
Präsentationen. In der Therapie und Beratung betroffener Patienten steht
die Kontrolle vaskulärer Risikofaktoren sowie die Empfehlung
körperlicher und kognitiver Aktivität zusammen mit einer guten
Schlafhygiene, die die perivaskuläre Drainage fördert, im
Vordergrund. Herausfordernd bleiben individuelle Konstellationen der
Ischämieprävention durch Antikoagulantien bei gleichzeitig hohem
Hirnblutungsrisiko, v. a. bei Vorliegen einer kortikalen superfizialen
Siderose. Die sehr dynamischen wissenschaftlichen und translationalen
Entwicklungen im Feld der zerebralen Mikroangiopathie zielen auf die Etablierung
von Bildgebungs- und anderen Biomarkern, z. B. in Blut und Liquor, ab,
die bereits die frühen Krankheitsstadien erfassen, bevor es zur
Hirnparenchymschädigung und klinischen Symptomen kommt. Entsprechend
fokussiert werden sich neue Therapieansätze auch dezidiert auf die
Stabilisierung der neurovaskulären Einheit und eine Verbesserung der
Drainagefunktion konzentrieren. Die Mikrovaskulatur und deren
Veränderungen spielen auch für das Verständnis anderer
neurologischer Erkrankungen aus dem Feld der primären Neuroimmunologie
und Neurodegeneration eine zentrale Rolle. Einige, bisher als separate,
neurologische Entitäten betrachtete Erkrankungen könnten
zukünftig folglich zunehmend als Spektrum ähnlicher
pathophysiologischer Prozesse verstanden werden. Das legt perspektivisch den
Grundstein für die Entwicklung und Anwendung überlappender
Therapiekonzepte.
Development and Update of Guideline-based Quality Indicators in Lung Cancer
Authors: Utzig Martin , Hoffmann Hans , Reinmuth Niels , Schütte Wolfgang , Langer Thomas , Lobitz Jessica , Rückher Johannes , Wesselmann Simone 
Published: December 2023

Abstract
Background In 2022, an update of the German lung cancer guideline, first published in 2010 and revised in 2018, was released. This article aims to show the process of updating, developing, and implementing guideline-based quality indicators (QI) into the certification system for lung cancer centers (LCC).

Methods A multidisciplinary and interprofessional working group revised the guideline QIs from 2018 using the strong recommendations of the guideline update, a systematic review for QIs, and the results of the implemented QIs from LCC.

Results For 4 out of 8 indicators from the 2018 guideline, the LCC showed an improved implementation of the requirements in the last 3 years (2018–2020). For 3 indicators, the median of the results was constant at a very high level (≥96% or 100%). Only the “adjuvant cisplatin-based chemotherapy” indicator showed declining values between 2018 and 2020. The target values and plausibility limits were well achieved by LCC. After updating the guideline, one QI from 2018 was not included in the new QI set due to the small denominator population. Based on the new strong recommendations, 8 new QIs were defined. From the QI set of the guideline update, 13 of 15 indicators (7 since 2018 and 6 from 2022 on) were adopted into the certification program.

Conclusions The guideline recommendations are implemented by LCC at a high level. The process presented confirms the successful implementation of the so-called quality cycle in oncology. The QIs developed by the German Guideline Program in Oncology (GGPO) are adopted by the certification program. The implementation of the QI is measured in LCC, evaluated by the German Cancer Society (DKG), and reflected back to the GGPO. The “real world” data have led to the deletion of one QI and show a high implementation of most QIs in LCC.