bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENEGAKAN DIAGNOSIS NEUROPATI AUDITORI : SEBUAH LAPORAN KASUS
Authors: Primadewi Novi , Anggraini Rinda Putri , Aditya Destar 
Published: October 2023

PENDAHULUAN
Neuropati auditori merupakan bagian dari tuli sensorineural, dimana suara dapat masuk hingga telinga dalam, tetapi transmisi sinyal dari telinga dalam ke otak terganggu pada jaras tertentu. Evaluasi klinis serta pemeriksaan yang tepat dibutuhkan pada penegakkan diagnosis neuropati auditori sehingga tatalaksana yang tepat dapat segera diberikan.
LAPORAN KASUS
Dilaporkan seorang anak laki-laki umur 1 tahun 8 bulan dengan keluhan belum dapat bicara sesuai usianya dan tidak respon terhadap panggilan ataupun suara keras. Pasien mempunyai riwayat hiperbilirubinemia pada usia 2 minggu. Pasien dilakukan pemeriksaan OAE dengan hasil normal, ABR/BERA terdapat gelombang mikroponik koklea pada intensitas 90-95 dB dan tidak tampak gelombang V pada intensitas 70-95 dB dan ASSR hasil ambang dengar gangguan derajat berat.
DISKUSI
Diagnosa neuropati auditori dapat ditegakkan dengan pemeriksaan Otoacoustic Emission (OAE) dengan hasil fungsi sel rambut luar koklea normal dan pada auditory brainstem respons (ABR/BERA) didapatkan Cochlear Microphonic (CM) normal atau pernah ada dalam satu waktu tetapi respons gelombang tidak normal atau tidak ada. Pada kasus ini telah dilakukan penegakan diagnosis yang sesuai dengan panduan.
KESIMPULAN
Diagnosa neuropati auditori dapat ditegakkan dengan pemeriksaan Otoacoustic Emission (OAE) dengan hasil fungsi sel rambut luar koklea normal dan pada auditory brainstem respons (ABR/BERA) didapatkan Cochlear Microphonic (CM) normal atau pernah ada dalam satu waktu tetapi respons gelombang tidak normal atau tidak ada.
Long‐Term Cumulative High‐Sensitivity C‐Reactive Protein and Mortality Among Patients With Acute Heart Failure
Authors: Zhang Lihua , He Guangda , Huo Xiqian , Tian Aoxi , Ji Runqing , Pu Boxuan , Peng Yue 
Published: September 2023

Background
Elevated hsCRP (high‐sensitivity C‐reactive protein) level is associated with worse prognosis among patients hospitalized for heart failure. However, the prognostic value of the long‐term cumulative hsCRP remains unknown.

Methods and Results
We consecutively enrolled patients hospitalized for heart failure and collected their hsCRP data at admission and 1 and 12 months after discharge. Long‐term cumulative hsCRP was evaluated using 2 approaches, cumulative hsCRP level quartiles and cumulative times of high hsCRP levels. Patients were classified into 4 groups by cumulative hsCRP level quartiles and cumulative times of high hsCRP levels (0‐ to 3‐times: number of times that hsCRP levels were higher than cutoff values at admission or 1 or 12 months), respectively. Multivariable Cox models were used to assess the association of mortality with cumulative hsCRP. A total of 1281 patients were included; the median age was 64 (interquartile range, 54–73) years, and 35.4% were women. Over a 4.8‐year (interquartile range, 4.2–5.1) follow‐up, 374 (29.2%) patients died. Elevated long‐term cumulative hsCRP level was related to higher mortality. Specifically, taking the quartile 1 as the reference, the hazard ratios (HRs) were 1.29 (95% CI, 0.92–1.81) for quartile 2, 1.62 (95% CI, 1.16–2.25) for quartile 3, and 2.38 (95% CI, 1.75–3.23) for quartile 4. Similarly, compared with the patients with 0‐times (hsCRP level lower than the cutoff values in all 3 time points) of high hsCRP level, the HRs were 1.36 for 1‐time (hsCRP level higher than the cutoff value in one of the 3 time points) (95% CI, 0.92–2.01), 1.95 for 2‐times (hsCRP levels higher than the cutoff values in 2 of the 3 time points) (95% CI, 1.34–2.82), and 2.80 for 3‐times (hsCRP levels higher than the cutoff values in the 3 time points) (95% CI, 1.97–4.00).

Conclusions
Increasing long‐term cumulative hsCRP level was associated with worse outcomes in patients hospitalized for acute heart failure. Repeated hsCRP measurements could assist physicians in identifying patients with a high risk of death.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT 02878811.
Breaking the Culture of Silence and Women’s Protection Groups in North and South Kivu (Democratic Republic of Congo)
Authors: Allouche Jeremy , Nazneen Sohela , Mugumo Mushi , Kuliumbwa Lulego Eustache , Hamuli Irene 
Published: September 2023

Abstract
Dynamics of a protracted conflict and restrictive norms and customs have created gender specific vulnerabilities for women living in rural areas of the eastern Democratic Republic of Congo (drc). Despite a growing awareness about women’s rights and protection needs among state actors and local authorities, women’s agency to break the culture of silence around violence remain limited. Based on extensive field work with selected communities in North and South Kivu in eastern drc, we analyse how this culture of silence limits the agency of individual women to seek self-protection. We also examine the role of women’s groups in these study areas and the strategies these groups use to advocate for their self and collective protection needs. We argue that the use of various frames to gain support of stakeholders, creating informal networks with key figures to gain access, and building allies among men have enabled women members of these groups to challenge restrictive norms around women’s access to decision-making spaces and visibilised their presence in public and break the culture of silence. We also point out that the sustainability of these mechanisms is open to question and backlash against women’s groups remains a possibility.
Mechanical bowel preparations not supported in elective colo-rectal surgeries with anastomosis: A retrospective study
Authors: Leitz-Najarian Greta , Najarian Melissa 
Published: September 2023

Objective To analyze the risk and benefit of bowel preparations in elective colo-rectal surgery. Background Mechanical bowel preparations (MBPs) have been popularized in colo-rectal surgery since studies in the 1970s, but recent data has called their use into question and examined complication rates between patients with and without bowel preparations. Methods A retrospective case-review was performed consisting of 1237 elective colo-rectal surgeries performed by two surgeons between 2008 and 2021. Patients received either a MBP, a mechanical bowel preparation with oral antibiotics (OAMBP), oral antibiotics alone (OA), or no bowel preparation; some patients across all categories received an enema. Results Bowel preparations combined (MBP and OAMBP) totaled 436 patients and showed no statistically significant difference ( P > .05) in primary outcomes of wound infection and anastomotic leak when compared to the 636 patients without a bowel preparation and 165 patients with OA. The analysis controlled for comorbidities and presence of enema. Of secondary outcomes, urinary tract infections (UTIs) were significantly more common in patients who received a bowel preparation ( P = .047). All other outcomes showed no significant difference between groups, including complications on day of surgery; complications, readmission with and without surgery, and ileus formation within 30 days of surgery; sepsis; pneumonia; and length of stay (LOS). The presence of enemas did not have a statistically significant effect on outcomes. Conclusions This study’s data does not support the routine use of MBPs in elective colo-rectal surgery and draws into further question whether MBPs should remain standard of care.
Where “Here” and “There” Intersect: The Role of Transnational Spaces in Civic Identity Development Among Educational Sojourners in the United States
Authors: Filip-Fouser Marta 
Published: September 2023

Background/Context: Few studies have examined civic identity development among international individuals on educational sojourns in the United States. This study broadens our understanding of processes that facilitate meaning making of sojourn experiences among socioeconomically diverse international students from Thailand. Specifically, I focus on examining transnational spaces as platforms for social interactions, exchange of ideas, and development of individual and collective practices, and their overall impact on the civic self. Research Design: Data for this study were collected through semi-structured individual interviews with 21 Royal Thai Scholars who pursued multiyear study in the United States and then returned to their home country to contribute their knowledge and skills. Participants were at different points of their educational sojourns at the time of the data collection; 16 were enrolled in boarding schools, colleges, or universities, and five completed their studies and returned to Thailand. Conclusions: Findings suggest that transnational spaces play three roles that contribute to the development of civic self: they afford opportunities for connection with other transnational individuals to process sojourn experiences and help develop strategies to navigate them; they serve as political socialization spaces in which youth become aware of and connected to their communities; and they serve as platforms where youth develop criticality, voice their opinions, and build empathy. The study highlights the importance of creating intentional opportunities for international students that help them develop cognitive, emotional, moral, and active engagement skills, process their experiences, and facilitate the formation of their transnational civic identities.
Clinical characteristics and outcomes of patients with leptospirosis complicated with acute pancreatitis: a systematic review
Authors: Charles James C , Jayarajah Umesh , Subasinghe Duminda 
Published: September 2023

Objectives Acute pancreatitis (AP) is a severe complication of leptospirosis. This review focuses on the current evidence of AP in patients with leptospirosis. Methods Data on clinical characteristics, biochemical parameters, diagnosis, complications, critical care, fluid management, operative management, and outcomes were analyzed. This study was registered in PROSPERO (CRD42022360802). Results We included 35 individual case reports and 4 case series involving 79 patients. Sex was reported for 48 (60.7%) patients; 38 (48.1%) were male and 10 (12.6%) were female. The patients’ mean age was 45.13 (15–83 years). Acute kidney injury, thrombocytopenia, hypotension, and liver injury were the most common complications reported. Complete recovery was reported for 36 (45.5%) patients. Biochemical and radiological recovery was reported for 10 (12.6%) and 9 (11.3%) patients, respectively. Death was reported in 18 (22.7%) patients. Conclusion A high degree of clinical suspicion and different modalities of investigations are essential in the diagnosis of AP in leptospirosis. AP can be easily missed in leptospirosis because both conditions share similar clinical presentations and complications. Because of the high prevalence of acute kidney injury, judicious fluid management and close monitoring are mandatory.
Evaluating the Impact of Aevidum on Mental Health Knowledge, Attitudes, and Help-Seeking Behaviors in High School Students: A Mixed-Methods Study
Authors: Pattison Krista L. , Lehman Erik , Molinari Alissa , Costigan Heather , Pileggi Francesca , Stuckey Heather , Sekhar Deepa L. 
Published: September 2023

Purpose To compare Aevidum’s school mental health curriculum vs the curriculum plus Aevidum clubs in a mixed-methods study including pre/post surveys, a randomized clinical trial, and qualitative interviews. Design Concurrent mixed-methods: Aim 1) pre-post surveys evaluated curriculum only vs curriculum plus club schools separately regarding changes in knowledge, help-seeking, and school culture; Aim 2) randomized clinical trial compared curriculum only to curriculum plus club schools; Aim 3) qualitative school staff interviews enhanced understanding of school culture changes. Setting Curriculum delivered to 9th graders at ten Pennsylvania high schools; 5 schools randomized to start clubs. Subjects Students (surveys), staff (interviews). Intervention Aevidum curriculum plus/minus club. Measures Aim 1, mixed effects linear and logistic regression models for longitudinal data were used to analyze survey items at each time point. Aim 2, the same regression models were used, except models included a fixed-effect for group and group by time interaction effect. Aim 3, interviews were transcribed; a codebook was developed followed by thematic analysis. Results Pre-survey 2557 respondents; 49% female, 86% non-Hispanic white. Post-survey 737 (29% response rate). Aim 1, pre-post (Likert responses, larger numbers favorable) demonstrated increased student knowledge to identify depression (4.26 [4.19-4.33] to 4.59 [4.47-4.71], P < .001) and help a friend access support (4.30 [4.21-4.38] to 4.56 [4.40-4.71], P = .001). Help-seeking increased for phone helplines (1.61 [1.57-1.66] to 1.78 [1.70-1.86], P < .001), crisis textlines (1.60 [1.55-1.64] to 1.78 [1.70-1.86], P < .001), internet/websites (1.80 [1.75-1.85] to 1.99 [1.90-2.08], P < .001), school counselors ( P = .005) and teachers (.013). Aim 2, no significant differences in knowledge, help-seeking or culture between curriculum only vs curriculum plus club schools. Aim 3, staff (n = 17) interviews supported reduced stigma and increased mental health referrals. Conclusions Aevidum’s curriculum improved mental health knowledge and help-seeking; adding the club did not significantly change responses. Staff identified positive school culture impacts. Limitations include the lower post-survey response.
Influence of filler types on wear and surface hardness of composite resin restorations
Authors: Chen Fei , Sun Lijuan , Luo Hao , Yu Peng , Lin Jiang 
Published: September 2023

Objective: Wear and surface hardness of resin composites are of relevance from the clinical standpoint. With the incorporation of novel filler system, more studies need to be performed to investigate newly marketed resin composites. The objective of this study was to investigate the abrasive wear and surface hardness of dental restorative with different filler types. Methods: Nanohybrid filled Harmonize (HM) and Tetric N-Ceram (TNC), microhybrid filled Filtek Z250 (Z250), nanofilled Filtek Z350 (Z350) were included in the study. Twelve cylindrical resin composites specimens with 10 mm in diameter and 6 mm in thickness were prepared for abrasive wear test. Eight hundred cycles under 17 kg load were conducted for final wear by CW3-1 wear machine. The specimen was cleaned with an ultrasonic unit for 3 min followed with drying procedure. After measurement of weight loss and the density of specimens, the specimens were kept for measurement of surface hardness. Surface hardness was measured using a micro-hardness tester with a Vickers diamond indenter after polishing. Three specimens of each material were observed by scanning electron microscopy (SEM) after the abrasion to evaluate the morphology of the surface. Data were analyzed using one-way analysis of variance (ANOVA), followed by Tukey HSD test ( α = .05). Results: Z250 performed the least volume wear loss (41.1 ± 2.1 mm3), as well as the hardest value (102.7 ± 2.9 HV). There was no significant difference with the volume wear loss ( p = 1.000) and surface hardness ( p = 0.874) of HM and TNC. SEM images of nanohybrid filled HM and TNC represented smoother surface compared with other types of resin composites. Conclusions: Microhybrid Z250 showed the highest wear resistance and surface hardness, nanofilled and nanohybrid resin composites may still face the insufficient of wear and surface hardness quality.
Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study
Authors: Lerfald Maren , Lydersen Stian , Zotcheva Ekaterina , Nilsen Tom I. L. , Eldholm Rannveig S. , Martinez-Velilla Nicolas , Selbæk Geir , Ernstsen Linda 
Published: October 2023

Abstract
Background
There is lack of research on combinations of possible modifiable risk factors for dementia in a life-time perspective. Dementia has currently no cure, and therefore new knowledge of preventive factors is important. The purpose of this study is to investigate if changes in physical activity (PA) in combinations with systolic blood pressure (SBP) trajectories in mid to late life are related to development of dementia in older age.

Methods
This prospective cohort study uses data from four consecutive surveys of the HUNT Study, Norway. Dementia was assessed in the HUNT4 70 + sub-study (2017–19). Group-based trajectory modelling identified three SBP trajectories from HUNT1 (1984–86) to HUNT3 (2006–2008): low, middle, and high. Change in PA was categorized into four groups based on high or low PA level at HUNT1 and HUNT3 and were combined with the SBP trajectories resulting in 12 distinct categories. Logistic regression was used to estimate odds ratios (ORs) of dementia.

Results
A total of 8487 participants (55% women, mean age (SD) 44.8 (6.5) years at HUNT1) were included. At HUNT4 70 + , 15.2% had dementia. We observed an overall decrease in OR of dementia across the PA/SBP categories when ranked from low to high PA (OR, 0.96; 95% CI, 0.93 to 1.00, P = 0.04). Within PA groups, a low SBP trajectory was associated with lower OR for dementia, apart from those with decreasing PA. The strongest association was observed for people with stable high PA and low SBP trajectory (OR, 0.38; 95% confidence interval (CI), 0.13 to 1.10 and adjusted risk difference, -8.34 percentage points; 95% CI, -15.32 to -1.36).

Conclusion
Our findings illustrate the clinical importance of PA and SBP for dementia prevention and that favorable levels of both are associated with reduced occurrence of dementia.
Evaluation of ethanol and EDTA concentrations in the expression of biofilm-producing smf-1, rpfF genes in XDR clinical isolates of Stenotrophomonas maltophilia
Authors: Deilamani Mohadeseh Ostovari , Nikkhahi Farhad , Bakht Mehdi , Ali Alizadeh Safar , Fardsanei Fatemeh , Javadi Amir , Marashi Seyed Mahmoud Amin , Aslanimehr Masoumeh , Peymani Amir 
Published: September 2023

Abstract
Background
Stenotrophomonas maltophilia is able to cause infections in immunocompromised patients, and the treatment of this opportunistic pathogen is complicated due to its virulence factors, antibiotic resistance, and the ability of the bacteria to produce biofilm. The main goals of this study were to assess the susceptibility of extensively drug-resistant (XDR) isolates to ethanol and EDTA, and evaluating the synergistic effect of these disinfectants, and also survey the effect of exposure to sub-inhibitory concentrations of ethanol and EDTA on the expression of biofilm-producing smf-1, rpfF genes.

Results
The results showed that EDTA significantly increased the effectiveness of the ethanol and have a synergistic effect. All of the 10 XDR isolates included in the current study harbored smf-1 and rpfF genes and produced biofilm. After exposure to MIC, sub-MIC, synergism, and sub-synergism of ethanol and EDTA, the expression of smf-1 and rpfF genes was repressed significantly.

Conclusion
In the current study, it was indicated that the expression of biofilm-producing genes was repressed when bacteria are exposed to different concentrations of ethanol and EDTA. Future studies should include more complex microbial communities residing in the hospitals, and more disinfectants use in hospitals. Expression of other virulence genes in different conditions is suggested.
Comparison of different statistical models for the analysis of fracture events: findings from the Prevention of Falls Injury Trial (PreFIT)
Authors: Hossain Anower , Lall Ranjit , Ji Chen , Bruce Julie , Underwood Martin , Lamb Sarah E. 
Published: October 2023

Abstract
Background
Fractures are rare events and can occur because of a fall. Fracture counts are distinct from other count data in that these data are positively skewed, inflated by excess zero counts, and events can recur over time. Analytical methods used to assess fracture data and account for these characteristics are limited in the literature.

Methods
Commonly used models for count data include Poisson regression, negative binomial regression, hurdle regression, and zero-inflated regression models. In this paper, we compare four alternative statistical models to fit fracture counts using data from a large UK based clinical trial evaluating the clinical and cost-effectiveness of alternative falls prevention interventions in older people (Prevention of Falls Injury Trial; PreFIT).

Results
The values of Akaike information criterion and Bayesian information criterion, the goodness-of-fit statistics, were the lowest for negative binomial model. The likelihood ratio test of no dispersion in the data showed strong evidence of dispersion (chi-square = 225.68, p-value < 0.001). This indicates that the negative binomial model fits the data better compared to the Poisson regression model. We also compared the standard negative binomial regression and mixed effects negative binomial models. The LR test showed no gain in fitting the data using mixed effects negative binomial model (chi-square = 1.67, p-value = 0.098) compared to standard negative binomial model.

Conclusions
The negative binomial regression model was the most appropriate and optimal fit model for fracture count analyses.

Trial registration
The PreFIT trial was registered as ISRCTN71002650.
Effect of low-density lipoprotein level and mortality in older incident statin-naïve hemodialysis patients
Authors: Song Je Hun , Park Eun Hee , Bae Jinsuk , Kwon Soon Hyo , Cho Jang-Hee , Yu Byung Chul , Han Miyeun , Song Sang Heon , Ko Gang-Jee , Yang Jae Won , Chung Sungjin , Hong Yu Ah , Hyun Young Youl , Bae Eunjin , Sun In O. , Kim Hyunsuk , Hwang Won Min , Shin Sung Joon , Park Woo Yeong , Kim Hyoungnae , Yoo Kyung Don 
Published: October 2023

Abstract
Background
This study aimed to analyze low-density lipoprotein cholesterol (LDL-C) levels and their relationship with mortality in order to identify the appropriate lipid profile for older Korean hemodialysis patients.

Methods
We enrolled a total of 2,732 incident hemodialysis patients aged > 70 years from a retrospective cohort of the Korean Society of Geriatric Nephrology from 2010 Jan to 2017 Dec, which included 17 academic hospitals in South Korea. Of these patients, 1,709 were statin-naïve, and 1,014 were analyzed after excluding those with missing LDL-C level data. We used multivariate Cox regression analysis to select risk factors from 20 clinical variables among the LDL-C groups.

Results
The mean age of the entire patient population was 78 years, with no significant differences in age between quartiles Q1 to Q4. However, the proportion of males decreased as the quartiles progressed towards Q4 (p < 0.001). The multivariate Cox regression analysis, which included all participants, showed that low LDL-C levels were associated with all-cause mortality. In the final model, compared to Q1, the hazard ratios (95% confidence interval) were 0.77 (0.620–0.972; p = 0.027), 0.85 (0.676–1.069; p = 0.166), and 0.65 (0.519–0.824; p < 0.001) for Q2, Q3, and Q4, respectively, after adjusting for covariates, such as conventional and age-specific risk factors. The final model demonstrated that all-cause mortality increased as LDL-C levels decreased, as confirmed by a restrictive cubic spline plot.

Conclusions
In older hemodialysis patients who had not previously received dyslipidemia treatment, elevated LDL-C levels were not associated with increased all-cause mortality. Intriguingly, lower LDL-C levels appear to be associated with an unfavorable effect on all-cause mortality among high-risk hemodialysis patients.