bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post minería en Colombia: el camino hacia la sostenibilidad en la minería
Authors: Hernández Marco , Vallejo Tommy , Klinger Luis , Restrepo-Baena Oscar Jaime 
Published: January 2024

En este artículo se pretende realizar un diagnóstico sobre la situación actual del cierre de las minas en Colombia, transferir el conocimiento y experiencia vivida por Alemania por los autores en ese aspecto, identificar la normatividad que se ha establecido en el país hasta la actualidad con respecto a cierre minero, los desafíos que enfrenta el país, las iniciativas y posibles soluciones que ha efectuado el país en la actualidad para garantizar un cierre adecuado exponiendo casos de éxito y por último se concluye la necesidades, los responsables y la forma de abordar este tema tan importante y álgido para el país.
RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2
Authors: Yan Tingting , Lu Guangxin , Shang Rui , Hu Junhua , Zhu Chaobei , Jin Lingli 
Published: January 2024

AbstractObjectiveGastric cancer is the most frequent gastrointestinal malignancy with a poor prognosis. Rac GTPase activation protein 1 (RACGAP1) is a novel tumor promotor, whose detailed effect on gastric cancer remains to be further elucidated. Hence, this study identifies the action of RACGAP1 on gastric cancer and investigates the potential mechanism.MethodsRACGAP1 expression in gastric cancer was analyzed based on the data of The Cancer Genome Atlas (TCGA) database. Cell proliferation was measured by CCK-8 and colony formation assay. Cell migration and invasion were evaluated by transwell assay. Cell apoptosis was assessed by flow cytometry. Cell autophagy was evaluated via determining LC3.ResultsRACGAP1 presented at high level in gastric cancer cells. Overexpressed RACGAP1 potentiated gastric cancer cell proliferation, migration, and invasion. Besides, silenced RACGAP1 induced cell apoptosis and autophagy. Furthermore, RACGAP1 suppressed the expression of SIRT1 and Mfn2.ConclusionRACGAP1 was overexpressed in gastric cancer. RACGAP1 potentiated aggressive behaviors of gastric cancer, and suppressed cell apoptosis and autophagy via modulating SIRT1/Mfn2. RACGAP1 may be a valuable target in the treatment of gastric cancer.
Dynamic behavior of sorption of europium onto biotite flakes under the condition of saline groundwater
Authors: Chida Taiji , Seki Tsugumi , Watanabe Yuto , Niibori Yuichi 
Published: January 2024

AbstractThis study discussed the interaction between Eu and biotite in flakes under the coexistence of Na ions, considering saline groundwater. The sorption experiments were conducted by mixing an Eu solution with Na or K ions and biotite flakes at pH 5. Resultantly, the sorption of Eu gradually increased because of the diffusion into the layered structure of biotite flakes. Thereafter, the sorption amount of Eu with Na ions was less than that without Na ions, and Eu was hardly sorbed with K ions. Additionally, the apparent diffusion coefficients were estimated to be in the order of 10−13 m2/s based on a two-dimensional diffusion model. These values were lower than the effective diffusion coefficients in plutonic rock, which are employed to assess the performance of geological disposal systems. This indicates that the sorption of Eu in plutonic rock is restricted by the diffusion process in biotite flakes.
Graphical abstract
A clinical case of Urbach-Wiethe disease
Authors: Kobernik М. Yu. , Elkin V. D. , Sedova Т. G. 
Published: January 2024

A clinical description of Urbach – Wiethe disease (lipoid proteinosis), an extremely rare pathology, is presented, currently only 300 cases are known. This hereditary disease, transmitted by an autosomal recessive type, is associated with a mutation of the extracellular matrix 1 (ECM1) gene located on chromosome 1, locus 1q21. It is based on a violation of collagen synthesis and deposition of hyaline in the dermis along the collagen fibers, in the mucous membranes, sometimes in the internal organs. The chemical composition of hyaline is not completely determined; it is noted that it includes collagen, glycoproteins, lipids, proteoglycans. The disease begins in early childhood and is characterized by changes in the ENT organs and skin, confirmed by histological examination, which reveals thickening of the dermis, degeneration of collagen fibers, hyalinosis with deposition around the vessels, in their walls, around the sweat glands of ribbon-like, weakly eosinophilic, homogeneous substances, which include phospholipids, sometimes there may be cracks with deposition of lipids.
Patient V., born in 1990, the disease began almost from birth with the appearance of polymorphic rashes on the skin and hoarseness of the voice. In 1999, a histological examination of the affected skin was performed, confirming the diagnosis of lipoid proteinosis of Urbach – Wiethe. The skin pathological process is widespread, symmetrical, on the face it is represented by reticulated telangiectatic erythema, along the edge of the lower eyelids there are miliary nodules similar to a string of pearls. Hypoplasia and stagnant erythema of the auricles are determined. There are yellowish lenticular papules on the trunk and limbs, waxy translucent plaques of a dense consistency in the area of the extensor surface of the elbow joints. Besides, secondary hyperpigmentation and foci of atrophy were detected on the face, trunk and limbs. Skin changes are accompanied by lesion of the ENT organs in the form of bilateral maxillary sinusitis, frontitis, chronic pharyngitis, chronic laryngitis. Concomitant pathology is important: polyvalent sensitization, chronic hepatitis B, biliary dyskinesia against the background of gallbladder deformation, chronic gastroduodenitis. The patient has been on disability since 2000, needs dispensary supervision and correction of all identified violations.
Experimental studies of effectiveness of a new mineral complex for regeneration of epithelial tissues and skin
Authors: Mishlanov V. Yu. , Chereshnev V. А. , Vdovina G. P. , Burlutskaya А. А. , Zuev А. L. , Koshurnikova E. P. , Emelkina V. V. , Samartsev V. А. , Gavrilov V. А. 
Published: January 2024

Objective. To study the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver in model experiments of the planar skin wounds and acute bronchitis in laboratory animals for the development of new techniques of surgical and pulmonological diseases treatment.
Materials and methods. An experimental study of the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver was carried out on models of the planar skin wounds and acute bronchitis in rats.
Results. The results of histological examination of tissues showed the advantage of the mineral complex over the control groups of animals. The anti-inflammatory and regenerative activity of the mineral complex was established in a model of acute bronchitis and regenerative activity in a model of a planar skin wound.
Conclusions. The effectiveness of the mineral complex depended on the concentration of cerium ions and was manifested at a dose of 0.003 μg/kg of animal weight.
Clarithromycin: overview and its current clinical utility in the treatment of respiratory tract infections
Authors: Naik Prashant , Prabhat Divya , Shrivastava Rakesh , Nair Arun , Khandke Devendra 
Published: January 2024

Upper respiratory tract infection (URTI) is a common reason for medical consultation all over the world. Streptococcus A (Strep A) and other infections can cause sore throat as well as pharyngitis or tonsillitis. It may also result in post-infection sequelae, including acute post-streptococcal glomerulonephritis, acute rheumatic fever, and rheumatic heart disease. As a result, there is a need for an antibiotic that is effective, easy to administer, has a favorable sensitivity pattern, and preferably has some additional pharmacodynamic properties that complement the basic antibacterial profile. Clarithromycin is a macrolide antibacterial agent with broad-spectrum activity against respiratory pathogens. It is especially active against atypical Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella spp. It is well absorbed and stable at gastric pH. It is metabolized by the cytochrome P450 enzymes and forms 14-hydroxy clarithromycin, which is more active than the parent compound, especially against Hemophilus influenzae. It acts by preventing protein synthesis by binding to the 50S subunit of bacterial ribosomes. In dosages of 500 to 1000 mg/day for 5 to 14 days, clarithromycin is effective in the treatment of community-acquired upper and lower respiratory tract infections in hospital and community settings. It exerts significant anti-inflammatory, immunomodulatory, and post-antibiotic effects. It provides a viable option for the treatment of community-acquired respiratory tract infections, in both children and adults.
A cross-sectional study on drug utilization and it’s cost analysis in the urological disorders and other health issues in patients of a tertiary care hospital
Authors: Narendra Varma J , Satheesh Kumar E. , Subair Asna , Sunil Gouthaman , Narayana Swamy V. B. , Patil Sapna 
Published: January 2024

To evaluate drug utilization patterns in terms of WHO indicators, urological disorders, and other health issues in patients of a tertiary care hospital.After obtaining approval from the Institutional Ethics Committee, a cross-sectional study was carried out among 200 inpatients in a tertiary care hospital in Bangalore. The data were collected from the patient case profile and prescriptions and noted in a self-designed data collection form. The statistical analysis of the collected data was performed using SPSS software and Excel. In a study of 200 patients with urological disorders (129 males and 67 females), common co-morbidities included diabetes, hypertension, and hypothyroidism. Benign Prostate Hyperplasia (BPH) and Urinary Tract Infections (UTI) were the prevalent diagnoses. Prescribed drugs included analgesics, antipyretics (26.7%), antibiotics (18.1%), proton pump inhibitors (18.0%), anti-hypertensives (8.7%), anti-emetics (7.9%), anti-hyperlipidemic (7.6%), vaccines (7.5%), and loop diuretics (5.5%). Average drugs per prescription were 6.94, with 23.79% prescribed generically. Antibiotics accounted for 48% of encounters, and injectables were used in 52% of cases. All the drugs came from the essential list. Polypharmacy affected 58% of patients over 50 years, with 32 major interactions and observed adverse drug reactions. The current research provides valuable insights into the overall pattern of drugs used in urological disorders. Physicians should be encouraged to increase generic prescribing to reduce medication cost burdens as well as to avoid unessential drugs, which may lead to polypharmacy and may result in other medication-related problems.
Psychospołeczne funkcjonowanie osób sprawnych mających rodzeństwo z niepełnosprawnością – zarys problemu
Authors: Gindrich Piotr Alfred 
Published: January 2024

Artykuł zawiera przegląd badań dotyczących wybranych psychospołecznych aspektów funkcjonowania osób sprawnych (dzieci, młodzieży i dorosłych) mających rodzeństwo z niepełnosprawnością. Jego celem jest pokazanie w jaki sposób wybrane zmienne takie jak: style radzenia sobie z sytuacją wzrastania z rodzeństwem z niepełnosprawnością, płeć, wiek i kolejność urodzenia, rodzaj i stopień niepełnosprawności, status socjoekonomiczny i inne cechy rodziny, wpływają na funkcjonowanie psychospołeczne rodzeństwa sprawnego i jego relacje z siostrą lub bratem z niepełnosprawnością. Podkreślono również znaczenie wspomnianych zagadnień dla praktyki pedagogicznej, w tym zwłaszcza dla wsparcia rodzin doświadczających trudności powiązanych z niepełnosprawnością. W celu złagodzenia skutków długotrwałego stresu w rodzinie, sprawne rodzeństwo osób z niepełnosprawnościami powinno otrzymać specjalistyczną pomoc w różnych okresach życia. Jednakże, większe wsparcie jest wymagane w celu zaspokojenia potrzeb sprawnego rodzeństwa w rodzinach mniej licznych, niepełnych i biednych, wychowujących dzieci z niepełnosprawnościami.
What is the most important innovation in neurosurgical practice that will emerge in the next 10 years?
Authors: Howard Philip 
Published: January 2024

Brain computer interfaces BCIs are automated neurostimulators that analyse brain signals and translate them into output. They aim to allow modulation of neurological functioning at cellular and network levels without the need for clinician-performed adjustments. BCIs are beginning to progress from the research and development phase to their introduction into clinical neurosurgery. Some anticipated applications include advanced treatment of cerebral palsy and stroke, aiming to restore function to these patients. In time, they will become one of the most significant innovations in neurosurgery.
Provided here is a review of BCI research to date and their implementation into clinical neuroscience, aiming to highlight the importance of BCIs as a developing treatment modality in neurosurgery in the next decade.
A review of the literature was performed using Pubmed as the primary database. BCI applications, recent technological advancements and current challenges facing these devices were reviewed. Trends in research and development were considered and are discussed. It was found that significant developments have been made in manufacturing BCIs that can interpret cortical processes with adequate spatial and temporal resolution. It was shown that the number of procedures to implant neuromodulators taking place in the UK each year is increasing, with more funding provided for BCI research each year. Further to this, a review of publication data found that neuromodulation devices placed among the top new patent categories in neurosurgery in recent years, a large portion of which were BCIs. These results highlight the continually growing interest in BCI research and their application in neurosurgery.
In conclusion, BCIs will become an increasingly important area of innovation in neurosurgery. Advances in translational neuroscience, imaging technologies and signal analysis will provide clearer insights into disease processes, allowing increasingly complex devices to address current limitations in the treatment of these conditions.
PENINGKATAN HASIL BELAJAR MENGGUNAKAN MEDIA KOMIK DIGITAL MATERI TOLERANSI DAN KOMPETISI KEBAIKAN
Authors: Triasih Asti 
Published: January 2024

The learning of students during the covid-19 pandemic in Islamic Religious Education (PAI) lessons requires teachers to be innovative in using the media to cultivate the value of truth and honesty better. The learning media used by teachers must support digital comics, namely illustrated stories. The purpose of this study is to make the learning outcomes of students better. The research subjects were students of class XI MIPA3 which totaled 35 people. The study was designed as many as two cycles, with data retrieval through pre-cycle observation. Data collection techniques in this study are tests, observations. Tests are used to obtain data on learning achievements. The data collection tool used is a test using question items / question instruments to measure student learning outcomes. And Observation uses observation sheets to measure the participation rate of learners. The results of the observations that have been carried out are analyzed descriptively comparatively, namely by comparing values between cycles and indicators in the study. Observation with descriptive analysis based on the results of observation and reflection of each cycle. The results of this study show that digital comic learning media has a positive impact in improving student learning outcomes. This can be seen from the better student learning outcomes on the material presented by the teacher (learning completion increases from pre-cycle, cycle I, and II, namely 31%, 57%, and 91%, respectively.
PENINGKATAN HASIL BELAJAR MENGGUNAKAN MEDIA KOMIK DIGITAL MATERI TOLERANSI DAN KOMPETISI KEBAIKAN
Authors: IRYANI DEWI , Arwan Arwan , Saputra Ade Akhmad 
Published: January 2024

The research subjects is to determine the improvement of learning outcomes of Islamic religious education by using animated video media, student learning outcomes after using animated video media. This class action research method (PTK) uses stages in the form of cycles, namely cycle I, and cycle II. In each cycle there is planning, implementation, observation and reflection. The subjects of this study were all Class III A children as many as 24 children, III SD Negeri 223 Palembang. The results of the research, it can be concluded that the percentage of student learning outcomes is 37.50%. After using animated video learning media in the first cycle of 66.67%, while in cycle II the percentage of student learning outcomes was 95.83%.

Dari hasil penelitian dapat disimpulkan. Dalam pra tindakan diketahui bahwa persentase hasil belajar peserta didik sebesar 37,50%. Setelah digunakan media pembelajaran video animasi pada siklus I sebesar 66,67%, Sedangkan pada siklus II persentase hasil belajar peserta didik sebesar 95,83%. Penggunaan media video animasi dalam pelajaran pendidikan agama Islam Pada siklus I adalah sebelum anak memulai belajar tiap pertemuan, video animasi yang sudah disediakan di tayangkan dan anak memperhatikannya, Pada siklus II dilakukan sama halnya dengan siklus I, perbedaannya hanya pada video dimana pada video siklus II lebih menarik karena berupa animasi gambar lebih jelas, sedangkan di siklus I video animasi kurang tertampil dengan jelas. Peningkatan hasil belajar peserta didik sebelum dan sesudah menggunakan media video animasi terjadi pada siklus I, dan siklus II. Dari perbedaan mean atau rata-rata dari hasil belajar peserta didik dari ketuntasan secara klasikal di atas dapat peneliti simpulkan bahwa dengan menggunakan Media Video Animasi dapat Meningkatkan Hasil Belajar Peserta didik di kelas III SD Negeri 223 Palembang
Kontruksi Politik Atas Kepemimpinan Wanita : Studi Peran Qadhi Malik Adli Pada Masa Pemerintahan Ratu Abad Ke 17
Authors: Haryanto Toto 
Published: January 2024

Kontruksi Politik Atas Kepemimpinan Wanita (Studi Peran Qadhi Malik Adli Pada Masa Pemerintahan Ratu Abad Ke 17) Para Sultanah, khususnya Sultanah Shafiyyah al-Din mampu memerintah kerajaan tanpa oposisi berarti dari agamawan dan ulama, setidaknya sampai wafatnya Syekh ‘Abd al-Ra’uf Sinkili tahun 1693. Beliau tidak melihat seorang perempuan terlarang menduduki jabatan tertinggi dan justru menekankan atribut moral penguasa daripada fitur lainnya. Hal ini sangat penting bahwa para ratu memainkan peranan utama dalam menegosiasikan aturan perempuan dalam Islam dan berhasil mendapatkan dukungan berkelanjutan dari para elit agamawan. Ini mereka lakukan dengan mendasarkan otoritas mereka pada kehendak Tuhan dan melegitimasi kekuasaan mereka berdasarkan cara-cara di mana mereka menjalankan hukum Tuhan. merupakan faktor-faktor penentu muncul dan bertahannya kekuasaan ratu di Kerajaan Aceh ketika itu. Dimensi agama kelihatannya memainkan peran yang lebih besar dan determinan. Ini dapat dibuktikan dari kenyataan bahwa bagi masyarakat Aceh, kontroversi ini bukan merupakan isu politik semata, akan tetapi yang lebih penting bagaimana persoalan yang menyentuh wilayah agama. Hanya dengan dukungan agama, khususnya yang datang dari al-Raniri, perempuan pertama naik takhta, dan juga hanya dengan kekuatan agama, yaitu fatwa, kekuasaan perempuan berakhir di kerajaan ini. Persetujuan (dukungan) agama juga berperan sangat vital dibalik sejarah pemerintahan ratu yang panjang, dan tokoh yang utama dalam hal ini adalah al-Sinkili. Statusnya sebagai pemegang otoritas agama yang tertinggi di kerajaan sangat dihormati, sehingga pandangannya yang moderat dan dukungannya terhadap pemerintahan perempuan tidak mendapat tantangan yang serius.
TINDAKAN SOSIAL JAMAAH TAREKAT NAQSYABANDIYAH KHALIDIYAH
Authors: Dewi Nurfitria , Munir Munir 
Published: January 2024

Tindakan Sosial Jamaah Tarekat Naqsyabandiyah Khalidiyah di kecamatan dilatar belakangi oleh fenomena modern sekarang yang mengarahkan perilaku seseorang cenderung kepada gaya hidup modern yang berorientasi kepada gaya hidup bebas yang tidak didasari oleh perilaku keagamaan, sehingga lupa terhadap tujuan hidup di dunia ini, disebabkan mengikuti arus zaman yang serba berkecukupan melupakan seseorang terhadap jati dirinya dan mengesampingkan kebutuhan spirtiual untuk membentuk kepribadian yang baik. Berbeda dengan fenomena di atas sebagian masyarakat tetap konsisten dengan filosofi kesederhanaan, kesalehan untuk menjaga kualitas spiritual keagamaan. Pencarian manusia akan tujuan dan makna dari pengalaman hidup dan ketenangan bathin merupakan bagian spiritual, salah satu tradisi spiriritualitas Islam yang melembaga adalah tarekat. Dengan mengamalan ajaran tarekat Naqsyabandiyah Khalidiyah di kecamatan Mungka mampu mempengaruhi aspek pencapaian akhlak yang baik. Berdasarkan latar belakang tersebut jawaban yang hendak dicari adalah bagaimana eksitensi tarekat Naqsyabandiyah Khalidiyah di kecamatan Mungka, bagaimana pengamalan ajaran tarekat Naqsyabandiyah Khalidiyah di kecamatan Mungka, bagaimana rasionalitas praktek keagamaan tarekat Naqsyabandiyah Khalidiyah di kecamatan Mungka.Di kecamatan Mungka ajaran tarekat Naqsyabandiyah Khalidiyah mampu membimbing dan mengarahkan perilaku jama’ahnya menurut ajaran Islam, baik itu dari segi individu maupun perilaku sosial keagamaan di tengah-tengan masyarakat.
Communication Strategies of the Multipurpose Syari'ah Cooperative of Musi Sejahtera Palembang in Improving the Welfare of the Members
Authors: Taufik Muhammad 
Published: January 2024

The aim of this research was to identify the all-round business syari'ah cooperative development program, "Musi Sejahtera Palembang”. The research method used in this research was qualitative research method. The research data were obtained through observation, interviews and documentation. Furthermore, the data obtained were assessed by descriptive-analytic technique and will eventually be concluded as the final outcome of this study. From the results of the research it can be concluded that the communication strategy of the Syari'ah Serba Usaha Musi Sejahtera Palembang cooperative in improving the welfare of its members was carried out through personal individual and communication. Meanwhile, the factor supporting the implementation of cooperative activities is as follows: working good cooperation with various stakeholders as well as facilities and infrastructure support. Meanwhile the inhibiting factors are as follows: 1) the human resources were less qualified; 2) lack of Board to manage the membership of a cooperative; 3) lack of awareness ofthe members of Syari’ah Serba Usaha Musi Sejahtera Palembang Cooperative in participating actively and the system management ofSyari’ah Serba Usaha Musi Sejahtera Palembang was not doing well.
Pengaruh Fluktuasi Harga Emas, Tingkat Inflasi Terhadap Produk Gadai Emas Pada Bank Sumsel Babel Syariah
Authors: Apriani Anjeli , Panorama Maya 
Published: January 2024

This study aims to determine the effect of gold price fluctuations and inflation rates on gold pawn products at the Islamic Sumatra Babel Bank for the period 2013-2019. This research includes quantitative research. The method used in this research is using multiple linear regression analysis method with a sample during the period 2013-2019 and using descriptive analysis techniques. The population and sample that will be used in this study are Bank Sumsel Babel Syariah in the 2013-2019 period.Financing that uses gold as a product object is highly dependent on fluctuations in gold prices. Islamic banks before providing financing to customers must make an assessment of the pawned gold. Based on the results of the study, it can be concluded: first, the results obtained from the calculations in this study are known that gold price fluctuations have a negative or no effect on the distribution of gold pawn financing and so is the second hypothesis that there is no effect of the inflation rate on the distribution of pawn products. gold bank sumsel babel sharia period 2013-2019.