bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influential Social Determinants of Adherence to Preventive and Health Promotion Activities During Pregnancy and the First Year of Life: Systematic review
Authors: Romero-Barranca Julia , Garcia-Cabrera Emilio , Román Encarnación , Pharm Fátima Morales , Vilches-Arenas Ángel 
Published: November 2023

Abstract

Background Effective monitoring throughout pregnancy and the first year of life is a crucial factor in achieving lower rates of maternal and infant mortality. Currently, there is a limited body of research that addresses socioeconomic factors that contribute to the non-adherence to preventive and control measures during pregnancy and the first year of life. The objective of this review is to examine the available evidence on social determinants that influence participation in health promotion and preventive activities throughout the pregnancy journey and in infants during their first year of life. Methods We performed a systematic review of the literature searching in the major scientific databases (PubMed, Scopus, EMBASE, WOS, and Cochrane Library) for articles from February 2017 to May 2023 containing information on health inequities that impact participation in health promotion and preventive measures from pregnancy through the first year of an infant's life. Results A total of 12 studies were selected. Of them, three were performed in North America (US and Canda); Three in the middle east and Asia (Pakistan, China, and Malasia); two in Africa (Nigeria and Ethiopia), two in Europe (UK and Denmark) and two in Australia. The selected studies cover preventive measures during maternal care, vaccination, and immunisation during pregnancy and the first year of life and newborn screening and follow-up of the first 12 months of life. These social factors associated with a low adherence to health promotion activities during pregnancy and the first year of life include education, income, ethnicity, place of residence, and family characteristics. Conclusions Despite the diverse geographical distribution, it is observed that there are common social factors linked to a decrease in the adherence to preventive measures during pregnancy and in the early years of life.
Perceived Knowledge of University Females Community about Osteoporosis
Authors: Mohamed Asmaa Ghareeb , Amri Majed Suliman Al , Harbi Jalal Al 
Published: November 2023

Abstract

Osteoporosis is a progressive decline in the bone mass, which occurs with no alterations to the bone’s composition. It is associated with increased bone fragility that may eventually lead to fractures. This aimed to assess the university females' level of knowledge about osteoporosis and to investigate the relationship between females' demographic characteristics and level of knowledge. Descriptive, correlational, cross-sectional design was adopted for this study which includes 382 participants. A self-reported web-based questionnaire was used to recruit study participants. The results shows that two thirds of them 67.5% were in the age group 20–30 year and single. 67.3% get their knowledge from mass media and more than half of the respondents demonstrated had poor level of knowledge toward osteoporosis. Therefore, an educational based studies and programs should be targeted and directed to improve the awareness of the public toward osteoporosis.
Sequential Operation of Kasai Portoenterostomy and Liver Transplantation is Recommended in Biliary Atresia Children for Better Outcomes: A Propensity Score Matching Analysis
Authors: Chen Chen , Zhou Tao , Xi Zhifeng , Lu Yefeng , Zhang Jianjun , Gu Guangxiang , Xia Qiang 
Published: November 2023

Abstract
Background
Kasai portoenterostomy (KPE) is widely accepted for biliary atresia (BA) when diagnosed timely. However, the outcomes for many patients were not satisfactory and required liver transplantation (LT) subsequently. The aim of our study was to determine whether KPE could improve the post-transplant outcomes of BA children.
Methods
In this retrospective cohort study from 2006 to 2019, 1647 BA children were included and divided into two cohorts: those who underwent primary liver transplantation (pLT) (n = 599) and those who received KPE followed by LT (n = 1048). Propensity score matching (PSM) was conducted in a 1:1 ratio to balance basic characteristics and minimize the selection bias.
Results
Of 954 recipients after PSM, pLT group (n = 477) showed poor survival rate than KPE + LT group (n = 477) (p < 0.001), with 1-year survival rate of 87.2% and 94.7%, 5-year survival rate of 82.4% and 91.9% respectively. 59.2% of deaths happened within post-operative day 90, especially the first month (41.7%) after LT. pLT group had a significant higher mortality rate than KPE + LT group (15.5% vs 6.1%, p < 0.001). Pulmonary infection and post-LT liver failure were leading causes of death in pLT group compared with KPE + LT group.
Conclusions
KPE could improve the post-transplant survival for BA children. If diagnosed within 3 months, it is advisable to try KPE before considering LT for BA children.
Oxytocin attenuates sympathetic innervation with inhibition of cardiac mast cell degranulation in rats post myocardial infarction
Authors: Hu Hesheng , Yin Jie , Ge Weili , Yu Qingxia , Jing Yanyan , Yan Wenju , Liu Qian , Gong Liping , Yan Suhua , Wang Shuanglian , Li Xiaolu , Li Yan , Wang Jun 
Published: November 2023

Abstract
Aims: Sympathetic nerve hyperinnervation is the primary cause of fatal ventricular arrhythmia (VAs) following myocardial infarction (MI). Cardiac mast cells cause arrhythmias directly via degranulation. However, the role and mechanism of mast cell degranulation in sympathetic remodeling remain unknown. We investigated the role and mechanism of oxytocin (OT) in stabilizing cardiac mast cells and ameliorating sympathetic innervation.
Methods and Results:
MI was induced by coronary artery ligation. Western blotting, immunofluorescence staining, and toluidine staining of mast cells were performed to detect target protein expression levels and locations. Mast cells accumulated significantly in peri-infarcted tissues and were presentin a degranulated state. Mast cells expressed OTR, and OT infusion reduced the number of degranulated cardiac mast cellspost-MI. Eventually, sympathetic hyperinnervation was blunted as assessed by immunofluorescence for tyrosine hydroxylase (TH). Seven days post MI, the arrhythmia score of programmed electric stimulation in vehicle-treated rats with MI was higher than that in rats treated with OT. An in vitro study showed that OT stabilized mast cells via the PI3K/AKT signaling pathway. Further in vivo studies on OT deficiency mice showed worsening mast cell degranulation and sympathetic innervation on the opposite side.
Conclusions: OT pretreatment inhibited the degranulation of cardiac mast cells post MI and prevented sympathetic hyperinnervation by stabilizing mast cells via the PI3K/AKT signaling pathway.
Morphological, Phytochemical, Biochemical, and Enzymatic Evaluation of Pepper Species (Capsicum annuum L. and Capsicum chinense Jacq.) at Developmental Stages Under Drought Stress
Authors: Erol Ümit Haydar 
Published: November 2023

Abstract

Drought is an important abiotic stress factor that severely affects plant growth, especially in arid and semi-arid regions. The effect of limited irrigation on plant growth and its response depending on growth stages is critical for agriculture in these regions. This study was conducted to understand how different pepper species (C. annuum L. and C. chinense Jacq.) respond to drought conditions. Plants were subjected to four different irrigation regimes (100% field capacity (FC), 75% FC, 50% FC, and 25% FC) and three developmental stages (S1: 20 days after flowering, S2: 40 days after flowering, and S3: 60 days after flowering). The effects of drought on plant morphological growth, photosynthetic pigment content in leaves, phytochemical components [total phenolics (TPh), total flavonoids (TFv), and total antioxidant activity (TAa)], proline (PRL), protein (PRO), malondialdehyde (MDA), and activities of major antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), and peroxidase (POD)] were investigated. According to the results, drought had a negative effect on plant morphology and physiology of both species, and these effects differed between plant species. The amounts of phytochemicals, MDA, PRO, PRL, and antioxidant enzymes increased in higher percentages with increasing drought severity (especially at S2 and S3 growth stages) in C. annuum. Moreover, antioxidative enzyme activities were significantly higher in C. annuum with increasing stress severity, helping the species to overcome oxidative stress under drought conditions. In conclusion, the findings showed that C. annuum is a drought-tolerant species with much more stable morphological, physiological, and biochemical performances compared to C. chinense.
Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
Authors: Bloks Niek GC , Dicks Amanda , Harissa Zainab , Nelissen Rob GHH , Hajmousa Ghazaleh , Ramos Yolande FM , Almeida Rodrigo Coutinho , Guilak Farshid , Meulenbelt Ingrid 
Published: November 2023

Abstract

Background: Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among other risk factors, such as genetics and age, hyper-physiological mechanical cues are known to play a critical role in the onset and progression of the disease (1). It has been shown that post-mitotic cells, such as articular chondrocytes, heavily rely on methylation at CpG sites to adapt to environmental cues and maintain phenotypic plasticity. However, these long-lasting adaptations may eventually have a negative impact on cellular performance. We hypothesize that hyper-physiologic mechanical loading leads to the accumulation of altered epigenetic markers in articular chondrocytes, resulting in a loss of the tightly regulated balance of gene expression that leads to a dysregulated state characteristic of the OA disease state.
Results: We showed that hyper-physiological loading evokes consistent changes in ML-tCpGs associated with expression changes in ITGA5, CAV1, and CD44, among other genes, which together act in pathways such as anatomical structure morphogenesis (GO:0009653) and response to wound healing (GO:0042060). Moreover, by comparing the ML-tCpGs and their associated pathways to tCpGs in OA pathophysiology, we observed a modest but particular interconnected overlap with notable genes such as CD44 and ITGA5. These genes could indeed represent lasting detrimental changes to the phenotypic state of chondrocytes due to mechanical perturbations that occurred earlier in life. The latter is further suggested by the association between methylation levels of ML-tCpGs mapped to CD44 and OA severity.
Conclusion: Our findings confirm that hyper-physiological mechanical cues evoke changes to the methylome-wide landscape of chondrocytes, concomitant with detrimental changes in positional gene expression levels (ML-tCpGs). Since CAV1, ITGA5, and CD44 are subject to such changes and are central and overlapping with OA-tCPGs of primary chondrocytes, we propose that accumulation of hyper-physiological mechanical cues can evoke long-lasting, detrimental changes in set points of gene expression that influence the phenotypic healthy state of chondrocytes. Future studies are necessary to confirm this hypothesis.
Effects of freeze-thaw on bank soil mechanical properties and bank stability
Authors: Yang Zhen , Mou Xian You , Ji Hong Lan , Liang Zhi Hao , Zhang Jianghao 
Published: November 2023

Abstract

Riverbank instability in the seasonally frozen zone is primarily caused by freeze-thaw erosion. Using the triaxial freeze-thaw test on the bank of Shisifenzi Bend in the Yellow River section of Inner Mongolia, we investigated the changes in the mechanical properties of the soil at different freezing temperatures and freeze-thaw times, and analyzed the bank’s stability before and after freezing based on the finite element strength reduction method. The results showed that the elastic modulus, cohesion, internal friction angle and shear strength of the soil tended to decrease with the increase in the number of freeze-thaw cycles and the decrease in freezing temperature. After 10 freezing cycles at -5℃, -10℃, -15℃ and − 20℃, the modulus of elasticity of soil decreased by 40.84% ~ 68.70%, the cohesion decreased by 41.96% ~ 56.66%, the shear strength decreased by 41.92% ~ 57.32%, respectively. Moreover, the stability safety coefficient of bank slope decreased by 18.58% after freeze-thaw, indicating that the freeze-thaw effect will significantly reduce the stability of bank slope, and the bank slope is more likely to be destabilized and damaged after freeze-thaw.
Secure and Flexible Authorized Data Sharing for Smart Grid
Authors: Feng Yawen , Zeng Shengke 
Published: November 2023

Abstract
Data in smart grid requires security and privacy. Fine-grained access control provides possibility for various electricity companies and organizations to access owner data securely and flexibly for transdiscipline billing. Moreover, revocation should also be considered for key leakage. This work presents a secure authorized data sharing for smart grid scenario. The data access for electricity companies in this scheme is fine-grained and revocation against server-user collusion is achieved. The security analysis and experiment results show that our solution is privacy-aware and practical for smart grid.
Placental Pathology and Fetal Growth Outcomes in Pregnancies Complicated by Maternal Obesity
Authors: Jacobs Marni , Hietalati Samantha , Pham Donna , Arora Harneet , Mochizuki Marina , Santiago Gisselle , Vaught Jordan , Lin Erika , Mestan Karen , Parast Mana 
Published: November 2023

Abstract

Background:
The rising prevalence of maternal obesity presents a significant health concern because of the possible implications for obstetric complications and neonatal outcomes. Understanding the impact of obesity on placental structure and function as well as fetal growth and infant outcomes is important to improve the care of these potentially high-risk pregnancies. This study aimed to determine the effect of elevated maternal BMI on histopathologic patterns of placental injury and its consequences on fetal growth.
Methods:
Data were collected from an ongoing cohort of maternal-infant dyads in the UCSD Obstetric Registry spanning 2011–2020. Maternal characteristics, including BMI, hypertensive disease and diabetes, placental gross and histopathology, and infant characteristics, including sex and birthweight, were recorded and analyzed. ANOVA, chi-square tests, and log-binomial and linear regression models adjusted for relevant confounders were employed to determine associations between maternal BMI, specific patterns of placental injury, and infant birthweight percentiles.
Results:
Among 1366 maternal-infant dyads, placentas from overweight and obese mothers were heavier and demonstrated higher adjusted relative risks of chronic villitis (CV), decidual vasculopathy, intervillous thrombosis, and normoblastemia. Placental efficiency, determined by fetal-placental weight ratio, was decreased with increasing BMI. Maternal obesity was associated with higher rates of preterm birth and higher birthweight percentiles. Multiple placental lesions, including maternal (MVM) and fetal vascular malperfusion (FVM), exhibited significant effects on birthweight percentiles; however, only MVM showed a differential effect based on maternal obesity.
Conclusions:
Maternal obesity is associated with increased rates of placental patterns of injury, decreased placental efficiency, and increased birthweight percentiles. While placental lesions, such as CV, have the potential to negatively impact fetal growth, the resulting birthweight percentiles demonstrate a more complex relationship between maternal obesity and fetal growth, that likely involves placental and fetal adaptation to the altered in utero environment.
Credit Evaluation Model and Its Application in Healthcare Insurance Fraud Detection
Authors: Zhao Xiaomin , Ding Zeyu , Huan Ruohong 
Published: November 2023

Abstract
Healthcare insurance fraud has become a major problem worldwide in recent decades, resulting in significant financial losses for every affected country. However, traditional fraud detection methods tend to focus on analyzing data from the current period and overlook historical information. In this study, we propose a novel approach inspired by the financial concept of ‘credit’ to detect fraudulent activities in various domains, such as healthcare insurance, credit card, and online retail transactions.Our approach aims to build a credit evaluation model that can differentiate between fraudulent and normal activities based on their historical records. We acknowledge that many fraud detection methods have been proposed, but they often struggle to detect edge cases, which limits their practical applicability. To overcome this challenge, we propose the Credit Evaluation Model (CEM), which uses a Time Interval-Aware Long Short-Term Memory (LSTM) algorithm to assist fraud detection. Moreover, we propose a new approach that transforms traditional binary classification into a multi-classification problem, which improves the model's ability to handle diverse fraudulent activities.We conducted experiments to evaluate the effectiveness of our proposed approach and model, comparing them against baseline algorithms and recently proposed methods. The results show that our approach outperforms the others, demonstrating its potential for practical use in detecting fraudulent activities in various domains.
Floral pigments and their perception by avian pollinators in three Chilean Puya species
Authors: Mizuno Takayuki , Mori Shinnosuke , Sugahara Koutarou , Yukawa Tomohisa , Koi Satoshi , Iwashina Tsukasa 
Published: November 2023

Abstract

The Chilean Puya species, Puya coerulea var. violacea and P. chiliensis bear blue and pale-yellow flowers, respectively, while P. alpestris considered to be their hybrid-derived species has unique turquoise flowers. In this study, the chemical basis underlying the different coloration of the three Puya species was explored. We first isolated and identified three anthocyanins: delphinidin 3,3′,5′-tri-O-glucoside, delphinidin 3,3′-di-O-glucoside and delphinidin 3-O-glucoside; seven flavonols: quercetin 3-O-rutinoside 3′-O-glucoside, quercetin 3,3′-di-O-glucoside, quercetin 3-O-rutinoside, isorhamnetin 3-O-rutinoside, myricetin 3,3′,5′-tri-O-glucoside, myricetin 3,3′-di-O-glucoside and laricitrin 3,5′-di-O-glucoside; and six flavones: luteolin 4′-O-glucoside, apigenin 4′-O-glucoside, tricetin 4′-O-glucoside, tricetin 3′,5′-di-O-glucoside, tricetin 3′-O-glucoside and selagin 5′-O-glucoside from their petals. We also compared compositions of floral flavonoid and their aglycone among these species, which suggested that the turquoise species P. alpestris has an essentially intermediate composition between the blue and pale-yellow species. The vacuolar pH was relatively higher in the turquoise (pH 6.2) and pale-yellow (pH 6.2) flower species, while that of blue flower species was usual (pH 5.2). The flower color was reconstructed in vitro using isolated anthocyanin, flavonol and flavone at neutral and acidic pH, and its color was analyzed by reflectance spectra and the visual modeling of their avian pollinators. The modeling demonstrated that the higher pH of the turquoise and pale-yellow species enhances the chromatic contrast and spectral purity. The precise regulation of flower color by flavonoid composition and vacuolar pH may be adapted to the visual perception of their avian pollinator vision.
Deregulation of MicroRNA-146a and 155 Expression Levels might underlie complicated pregnancy in Toxoplasma gondii seronegative women.
Authors: Naguib Marwa M. , zaher Youssef Abdel , Ali Hemat Salah M. , Elnoury Hamasat Abdelhafiz , Mohammed Lina Abdelhady , Habashy Omnia Youssef , Mohammed Dina Abdelhady 
Published: November 2023

Abstract

Background
To evaluate the ability of the estimated plasma expression levels of genes of microRNA (MiR-) 146a and 155 to differentiate between samples of pregnant women suspected to be infected by T. gondii. 50 newly pregnant women who had at least one of the criteria of high risk for toxoplasma infection and 50 newly primigravida women free of these criteria gave blood samples for qualitative determination of serum toxoplasma antibodies and estimation of plasma expression levels of MiR-146a and 155 using the qRT-PCR. During the pregnancy course, the incidence of pregnancy complications was recorded
Results
Twenty-six women were IgM−/IgG−, 17 women were IgM+/IgG− and 7 women were IgM+/IgG+. Thirty-two women had pregnancy complications with significantly lower incidence in IgM−/IgG− women. Plasma expression levels of MiR-146a and 155 were significantly higher in total patients compared to control levels and were significantly higher in samples of IgM+/IgG+ patients than in other samples. Statistical analyses defined a high plasma level of MiR-155 as the highly significant predictor for oncoming pregnancy complications and high levels of both microRNAs as predictors for the presence of toxoplasmosis despite seronegativity. Kaplan-Meier regression analysis defined increasing cumulative risk of having toxoplasmosis despite seronegativity with plasma levels of MiR-146a and MiR-155 of 1.2 and 3, respectively.
Conclusion
The incidence of pregnancy complications is high, irrespective of the seronegativity of women at high risk of toxoplasmosis. Estimated plasma levels of MiR-155 might identify women liable to develop complications and differentiate seronegative women vulnerable to having T. gondii infection.
Trial registration:
The study protocol was approved preliminarily by the Local Ethical Committee at Benha Faculty of Medicine. Before enrollment, the study protocol was discussed in detail with the study participants, and those accepted to participate in the study signed written fully informed consents. The final approval of the study protocol was obtained after the end of case collection and registered by RC: 5-11-2022.
Analysis of the OutagePerformance of Energy-Harvesting Cooperative-NOMA System with Relay Selection Methods
Authors: Zhou Yulin , Zhang Yang , Hui Xiaonan , Wang Zhao , Khuwaja Aziz Altaf 
Published: November 2023

Abstract
In this paper, we propose a cooperative Non-Orthogonal Multiple Access (NOMA) transmission scheme with energy-harvesting, employing channel estimation to obtain accurate Channel State Information (CSI) through the Least Squares (LS) channel estimation procedure. The objective is to establish an optimal communication path between the source and the destination. To achieve this, we compare the performance of two relay selection methods: Optimal Relay Selection (ORS) and Max-Min Relay Selection (MMRS). We analyze the impact of the number of relays and the power allocation factor on the system's performance, specifically focusing on the outage probability expressions. Furthermore, we compare cooperative-NOMA with cooperative relaying without NOMA. Numerical and simulation results confirm that the cooperative-NOMA system outperforms the traditional relaying system without NOMA. Additionally, ORS demonstrates superiority over MMRS in terms of the outage performance.