bluuebunny/crossref_metadata_2025_split huggingface dataset:
A - 106 Predicting Depression in Individuals with Parkinson’s Disease Using the Repeatable Battery for the Assessment of Neuropsychological Status
Authors: Richardson Spring 
Published: October 2023

Abstract

Objective
This study investigates whether deficits in specific cognitive domains predict depression in individuals with Parkinson’s disease.

Method
Neurocognitive domains are measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Affective symptoms are measured by the Personality Assessment Inventory (PAI). A simultaneous hierarchical multiple regression with three univariately predicting RBANS indices was used to predict the PAI Depression Scale. Participants were individuals diagnosed with Parkinson’s disease who underwent neuropsychological evaluation as candidates for deep brain stimulation procedures. The sample included 31 participants, between ages 41 to 75, with a mean age of 61.29. Twenty-seven were male and four were female. Twenty-six were white, one was African-American, one was Hispanic, one was Asian, two were not racially identified.

Results
The model was significant with a large effect size, R2 = 0.444, F(3,27) = 7.177, p &lt; 0.001, indicating Attention, Visuospatial/constructional, and Immediate Memory RBANS indices accounted for 44% of the variation found in depression as measured by the PAI. Attention had 15% of unique variance accounting for one third of the 44% predicted by the regression model. Visuospatial/constructional had 9% unique variance, indicating that approximately 20% of the model variance is in common between the predictors and depression.

Conclusions
The analysis found a significant negative correlation between depression and cognitive deficits, supporting the hypothesis that cognitive deficits in one or more of the RBANS domains predicts depression in individuals with Parkinson’s disease.
A - 110 Cognitive Phenotypes in Children with a History of Brain Tumors
Authors: Robinson Mary L , Bean Akanksha M , Schneider Bruna M , Krapf Erica M , Hassara Kathleen E 
Published: October 2023

Abstract

Objective
Research indicates children with a history of pediatric brain tumors (PBTs) are at increased risk for cognitive impairment. Cognitive phenotyping could reveal latent cognitive profiles and ascertain the impact of clinical and sociodemographic variables in this population. There is only one such study to date. We hypothesized patients with more treatment modalities, additional medical diagnoses, and diagnosis age/time since treatment completion would impact performance.

Method
K-means clustering was used to explore 17 test scores across 9 cognitive domains in 67 children with brain tumors aged 8–17 years (median age = 12; 41 male; 85.1% Caucasian) in a pediatric hospital. Exclusion criteria included failed performance validity testing, IQs &lt; 50, and active treatment. Parametric and non-parametric tests were utilized, and effect sizes were calculated.

Results
Two clusters were identified. Cluster 2 (n = 37) had lower scores than Cluster 1 (n = 30) on all neuropsychological domains assessed except for memory and mental flexibility with large effect sizes (p’s &lt; 0.005, n2 = 0.151–0.57). Clusters differed by tumor location (p = 0.021, V = 0.340), hydrocephalus (p = 0.041, V = 0.250), and treatment type (p = 0.037, V = 0.447).

Conclusion(s)
Results suggest multi-domain cognitive impairment in a large subgroup of children with PBTs associated with infratentorial tumors, history of hydrocephalus, and exposure to multiple treatment modalities (i.e., surgery, radiation, and chemotherapy). Other demographic, treatment (i.e., diagnosis age, time since diagnosis/treatment completion), and medical (i.e., tumor grade, seizures, genetic diagnoses) factors did not account for clusters. Future studies should include larger samples, increased age range, and additional clinical, sociodemographic, and psychosocial variables to form more generalizable models of cognitive phenotypes in youth with PBTs.
A - 111 Neuropsychological Performance in CDK-13 Related Disorder: a Multi-Year Case Study
Authors: Robinson Mary L , Bean Akanksha M , Krapf Erica M 
Published: October 2023

Abstract

Objective
CDK13-related disorder (CDK13-RD) is a rare genetic condition first described in 2016 as involving congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD). Few studies have reported clinical presentations. There is very minimal information about cognitive and neuropsychological outcomes; however, developmental delays and intellectual disability are common. This study presents longitudinal neuropsychological outcomes of one adolescent with CKD13-RD.

Method
A female patient underwent five neuropsychological evaluations over eight years due to learning concerns. Pregnancy complications included recurrent maternal infections/treatment and fetal heart deceleration. The patient was born at full-term with average birthweight. Patient’s history includes developmental delays, cerebral palsy, learning disabilities, anxiety, atrial septal defect, abnormal MRI and EEG, submucous cleft palate, velopharyngeal insufficiency, and craniofacial dysmorphisms. Genetic tests confirmed a likely pathogenetic variant in the CDK13-gene at 9-years-old.

Results
Patient’s intellectual functioning varied during the five evaluations, with heterogeneous performance across indices. Verbal comprehension was often a strength in the low average to average ranges. Visual perception, nonverbal reasoning, fine motor coordination/planning, attention, and aspects of executive functioning were consistently impaired. Memory across evaluations was variable but broadly average. Caregiver reports revealed increasing executive and adaptive functioning concerns and fluctuating mood/behavioral concerns across evaluations.

Conclusions
Patient’s overall intellectual functioning is generally stronger than expected compared to the few available studies. This case adds to the scarce literature on neuropsychological outcomes in children with CKD13-RD and helps elucidate developmental trends given these serial results. Additional research is needed to better understand neuropsychological presentations and long-term outcomes in children with CKD13-RD.
A - 117 Neuropsychological Profile of CSF1R-Related Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia
Authors: Taylor Sarah E , Naini Savana M , Eskridge Courtney , Holker Erin , Logemann Allison M , Porter James , Whiteside Douglas M , Waldron Eric J 
Published: October 2023

Abstract

Objective
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rapidly progressive neurodegenerative disorder caused by mutations in the CSF1R gene and is characterized by white matter disease, seizures, motor and cognitive impairment, and personality change. However, the existing neuropsychological literature on ALSP is limited. This exploratory study describes the cognitive profile of patients diagnosed with CSF1R-related ALSP.

Methods
7 patients with genetically confirmed CSF1R-related ALSP (Mage = 43.71, SD = 1.6; Meducation = 15.71, SD = 1.89; 71% female; 100% white) underwent neuropsychological examination as part of a pre-bone-marrow transplant work-up. Patients completed tests assessing all standard cognitive domains. Given variability in tests between evaluations, domain means were calculated for each patient and used to calculate frequencies of poor (below average and exceptionally low range) cognitive performance by domain.

Results
Two patients were asymptomatic at the time of the evaluation and performed in the low average to exceptionally high range across domains. Of the remaining patients, the average time between symptom onset and the neuropsychological evaluation was 1.6 years (SD = 0.55). Below average to exceptionally low range performances were most often observed in executive functioning (80%) and processing speed (80%) domains. 60% of symptomatic patients showed poor performances in attention, verbal skills, visual skills, and fine motor functioning domains.

Conclusions
Consistent with prior research, results suggest primarily frontal and subcortical system dysfunction. Neuropsychologists may be uniquely qualified to aid in detecting subtle cognitive changes in ALSP patients that may be critical for early detection of symptoms and treatment planning. Future studies should evaluate these findings in large and more diverse samples.
A - 118 Disenfranchised Grief as a Part of Acquired Brain Injury Recovery: Role of the Feedback Session
Authors: Tozser Timea , Williams Julie 
Published: October 2023

Abstract

Objective
Disenfranchised grief is a response to events or a loss that society does not acknowledge, such as a loss of sense of self, opportunity, or one’s functioning. During the neuropsychological assessment process, this societal construct can often overlook the bereavement of one’s “old self,” which diminishes the opportunity for processing loss. This poster highlights the societal creation and further perpetuation of disenfranchised grief among individuals with ABI and neuropsychologists’ duty to name it in feedback sessions, igniting holistic recovery.

Data Selection
A literature review of peer-reviewed articles from 2011 to 2022 from PubMed and Google Scholar was conducted. Keywords include disenfranchised grief, acquired brain injury, neuropsychological feedback, brain injury, neuropsychological testing, stroke, and TBI.

Data Synthesis
The societal taboo surrounding non-death grief prevents individuals from processing this grief. Implications of unaddressed disenfranchised grief can include changes in one’s sense of self, withdrawal, feeling powerless, depression, and anxiety. Disenfranchised grief commonly emerges following acute rehabilitation. This can impact optimal cognitive performance during the assessment and daily functioning.

Conclusions
The social construction of the onset of disability perpetuates the inability to acknowledge grief following brain injury. Neuropsychologists can use the feedback session to initiate the healing process surrounding disenfranchised grief. Normalizing this aspect of recovery can allow individuals and their families to holistically understand changes after brain injury and acknowledge adapting to a new way of life. Future studies should explore how the cultural implications of disenfranchised grief impact conceptualization.
A - 119 A Case Study: the Cognitive Functioning of an Adult Patient with Recurrent Craniopharyngiomas
Authors: Tse Phoebe Ka Yin , Basurto Karen S , VanLandingham Hannah , Oh Alison , Alfonso Demy , Jennette Kyle 
Published: October 2023

Abstract

Objective
Craniopharyngiomas are extremely rare (incidence rate of 1.34 per million). Due to its proximity to the sellar/suprasellar prefrontal regions region, cognitive impairment, behavioral changes, and adverse endocrinological outcomes are common. Further, surgery and radiotherapy can further impact functioning. Currently, there is no parsimonious cognitive profile of adult patients following interventions. This case highlights the role of neuropsychological evaluations in monitoring global psychological functioning and frontal behavioral syndrome in an adult with recurrent craniopharyngioma.

Method
The patient is a 39-year-old Black female first evaluated as an inpatient prior to resection surgery. She was evaluated on four additional times post-surgically. At the most recent evaluation, she and her family reported memory problems, apathy, and gait instability. Complicating factors included hypothyroidism, chronic kidney disease, diabetes, obstructive sleep apnea, pulmonary embolism, hypotension, COVID-19, and recurrent tachycardia, with inconsistent adherence to treatment recommendations.

Results
She displayed global cognitive deficits two years post-surgery, particularly in language and memory. Neurobehaviorally, she exhibited pervasive signs of severe frontal lobe syndrome, including, abulia, hypophonic and dysarthric speech, psychomotor retardation, bradyphrenia, and anosognosia.

Conclusion
Neuropsychological evaluations remain critical in monitoring the patient’s neurocognitive status and provide valuable insights into treatment planning and need for additional support and care to optimize patients’ quality of life in the context of significant cognitive disability.
A - 121 Psychosocial and Neurocognitive Correlates of Suicidal Thoughts and Behaviours Amongst Siblings of Persons with and without Neurodevelopmental Conditions
Authors: Wolff Brittany , Magiati Iliana , Pestell Carmela , Glasson Emma 
Published: October 2023

Abstract

Objective
Siblings of individuals with neurodevelopmental conditions (NDCs) have greater incidence of psychiatric diagnoses and neurocognitive difficulties compared to siblings of persons without NDCs. Despite suicidality being labelled a global health crisis, and NDC siblings experiencing risk factors implicated in suicidality, no previous studies examined suicidality amongst adolescent and young adult siblings of persons with NDCs. Our study aimed to bridge this gap.

Method
The present study used Bayesian analyses and risk classification models to examine individual and environmental risk factors associated with suicidal thoughts and behaviour amongst siblings of persons with and without NDCs (n = 267; 132 NDC, 135 control group, mean age 20.61, range 14–27, 76.40% female, 76.78% White Caucasian), as measured using self-report survey data and remote self-administered cognitive tests.

Results
NDC siblings had higher rates of current nonsuicidal self-injury (NSSI; 18.94% versus 14.07%, δ = −0.32), suicidal ideation (25.76% versus 8.89%, δ = −0.40) and history of suicide attempts (18.18% versus 4.44%, δ = −0.43) compared to controls. Classification models using boosting and random forest demonstrated adequate performance: positive predictive value 0.86–0.91, negative predictive value 0.81–0.90, false negative rates 0.11–0.24. Cognitive inflexibility, alexithymia, inattention, bullying, depression, NSSI, and eating or psychotic disorder history had the highest relative importance in predicting lifetime suicidality. Poorer executive functioning (measured by the Wisconsin Card Sorting Task, Sustained Attention to Response Task, Stop Signal Task, and N-Back 2-back task) was strongly correlated with suicidality.

Conclusions
Screening for proximal and modifiable risk factors is critical to inform suicidal behaviour intervention and prevention programs for at-risk siblings.
A - 123 Depression and Negative Symptoms Predicting Memory and Verbal Fluency in Psychotic Major Depression
Authors: Jariwala Namasvi , Sotelo Lizeth , Wu Ying Hua , Ghuman Sabrin , Kiefer Jamie P , Gomez Rowena 
Published: October 2023

Abstract

Objective
Although substantial research exists regarding negative symptoms and depression impacting cognitive functioning in schizophrenia, research in major depression with psychotic features (psychotic major depression; PMD) is limited (Calderon-Mediavilla et al., 2021). This study investigates if negative symptoms can predict delayed verbal memory and verbal fluency in individuals with PMD, after controlling for depression severity.

Method
As part of a larger study, 49 adults with PMD (57% female; Mage = 37.7 years) were administered the following measures. The Hamilton Depression Rating Scale measured depression severity. A negative symptoms composite score was made with items from the Brief Psychiatric Rating Scale. The California Verbal Learning Test-II measured verbal memory. The Controlled Oral Word Association Test measured verbal fluency.

Results
Depression and negative symptoms were not significantly correlated (r = 0.08, p &gt; 0.05). After controlling for depression severity, negative symptoms explained an additional 8.5% of the variance in long-delay free recall (Adjusted R2 = 12%, p &lt; 0.05). Depression and negative symptoms were significant unique predictors (β = 0.302, β = −0.29, respectively; ps &lt; 0.05). After controlling for depression severity (which was not a significant predictor), negative symptoms explained 14.9% of the variance in verbal fluency (p &lt; 0.05).

Conclusions
Negative psychotic symptoms are just as important or more important than depression severity in predicting verbal fluency and memory for individuals with depression who experience psychotic symptoms during a depressive episode. These findings improve the understanding of cognitive functioning in individuals with PMD, which can impact treatment planning.
A - 128 Sex Differences in CBF in a Pediatric Sample of Depression: a SPECT Analysis
Authors: Stafford Claire , Amen Daniel , Golden Charles , Willeumier Kristen 
Published: October 2023

Abstract

Objective
The present study aims to determine whether there are differences in cerebral blood flow (CBF) levels in females versus males with depression.

Method
The data for this study was derived from an archival SPECT database. Participants in the female group (n = 140, Mage = 14.48) were like those in the male group (n = 241, Mage = 13.77). Multiple independent t-tests were performed between the female and male groups on the CBF levels in the left and right sides of the cerebellum, cingulum, frontal, occipital, parietal, and temporal lobes, and subcortical areas.

Results
CBF levels in males were higher than those of females in the following areas: the left and right sides of the cerebellum, and occipital lobe, the right side of the parietal lobe, and the temporal lobe. CBF levels in females were higher than those of males in the following areas: the left and right sides of the cingulum, the vermis, and the subcortical areas.

Conclusions
While females had higher CBF in subcortical areas, the findings regarding higher CBF levels in males raise questions regarding prior literature which suggested that females have higher CBF than males in studies of depression subjects. These differences may be due to the differences in how males and females cope with depressive symptoms. Sex differences in CBF may suggest a contributing factor in the relationship between sex and responsiveness to antidepressant medication, ketamine treatment, and transcranial magnetic stimulation.
A - 129 An Examination of the Relationship between Posttraumatic Stress Disorder Symptom Severity and Cognitive Test Performance in a Veteran Sample
Authors: Valencia Julianna P , Marceaux Janice C , Andrews Anthony P 
Published: October 2023

Abstract

Objective
This study examined the relationship between Posttraumatic Stress Disorder (PTSD) symptom severity and cognitive test performance in veterans, hypothesizing that PTSD Checklist for DSM-5 (PCL-5) scores would be correlated with test performance on commonly used neuropsychological measures.

Method
Clinically-referred veterans without a neurocognitive disorder who passed the Test of Memory Malingering (TOMM), completed the PCL-5, and completed Weschler Adult Intelligence Scale-Fourth Edition (WAIS-IV) Digit Span or Coding, Weschler Memory Scale-Fourth Edition (WMS-IV) Logical Memory (LMI/LMII), letter fluency (FAS), or Trail Making Test (Parts A and B) were included. The sample included 38 veterans (81.6% male); mean age = 58.79 (SD = 14.71; range 22–80) and mean education level = 13.97 years (SD = 2.42, range 6–20). Primary diagnoses included PTSD (47.4%), depression (21.1%), and no diagnosis (23.7%). Pearson, Spearman, and partial correlations were calculated.

Results
Moderate negative correlations were found between PCL-5 and FAS raw scores (r = −0.41, p = 0.014; 95%CI [−0.654,-0.089]) and LMI raw scores (r = −0.453, p = 0.02; 95%CI [−0.715,-0.080]). After controlling for age and education, moderate negative correlations remained for FAS (r = −0.46, p = 0.004) and LMI (r = −0.43, p = 0.018) and a weak, non-significant correlation with LMII (r = −0.297, p = 0.079).

Conclusions
In veterans with valid cognitive test performance and no neurocognitive disorder, PTSD symptom severity negatively correlated with FAS and WMS-IV LM performance. This suggests PTSD symptoms may influence performance on phonemic fluency and story recall task. Assessing and addressing PTSD symptoms may result in more accurate diagnoses and improved cognitive functioning. Understanding the PTSD-cognition relationship can inform interventions and support strategies to enhance veterans’ quality of life.
A - 130 Differences in Emotion Identification in Schizophrenia, Bipolar with or without Psychosis, and Healthy Controls
Authors: Gates-Woodyatt Jessica , Ringdahl Erik N , Salva Christine , Rairata Yuan , Jarvis Sierra , Allen Daniel N 
Published: October 2023

Abstract

Objective
Research suggests individuals with schizophrenia and bipolar with psychotic features have difficulty accurately identifying emotions expressed by others. Such findings raise questions to whether impairments in emotion identification are better explained by the presence of psychosis, regardless of diagnosis.

Method
The Emotion Evaluation Test (EET) of The Awareness of Social Inference Test (TASIT) was administered to individuals with schizophrenia (SZ; N = 22), bipolar disorder with psychotic features (BP+; N = 20), bipolar disorder without psychotic features (BP-; N = 21), and healthy controls (HC; N = 22). The EET comprises 24 video vignettes portraying happiness, surprise, sadness, anger, fear, disgust, and neutral emotions. Participants were prompted to identify the emotion in each vignette. Emotion identification of positive, negative, and neutral emotions was compared between groups.

Results
Group comparisons showed that the SZ group performed significantly worse than the other groups when identifying positive and negative emotions. The BP+ group performed significantly worse than BP- and HC when identifying negative emotions. No significant differences were found in neutral emotion identification between groups.

Conclusions
The BP+ group was less accurate in identifying negative emotions but not positive emotions compared to the BP- and HC groups. Further investigation is required to determine factors that contribute to this differential performance.
A - 133 Self-Reported Loss of Consciousness Predicts Executive Functions in Veterans with a History of Traumatic Brain Injury
Authors: Adhikari Ashna , Brooks Jared , Watson Kelsey , Morris Elizabeth E , LoBue Christian , Motes Michael , Cullum C Munro , Hart John , Chiang Hsueh-Sheng 
Published: October 2023

Abstract

Objective
The long-term cognitive effects of traumatic brain injury (TBI) in military personnel remain unclear and need to be better understood. We assessed how cognitive performance was related to the remote history of TBI involving loss of consciousness (LOC) and blast injury (regardless of LOC) in veterans.

Method
Veterans (N = 101; age 42.8 ± 10.5 years; 10 Females) with a self-reported history of TBI and persistent cognitive symptoms were recruited. Effects of (1) the presence of LOC, (2) total number of TBIs with LOC (0, 1–2, &gt;2), and (3) the presence of blast injury were examined on composite scores from tests of executive function (Trail-Making Test B, Color Word Interference), word retrieval (Boston Naming, Letter and Category Fluency), processing speed (Trail Making-A, Color Word Naming/Reading), and episodic memory (Rey-Auditory Verbal Learning Test-total learning and delayed recall), while controlling for age, sex, years of education, and total number of TBIs.

Results
TBI with LOC was a significant predictor of executive function (p = 0.014) and processing speed (p = 0.014), with more episodes of LOC predicting lower functioning, but not of word retrieval or episodic memory (p &gt; 0.1). Additionally, presence of a blast injury, regardless of LOC, did not predict differences in function on any of the composite measures.

Conclusions
Self-reported TBI history with LOC was associated with poorer executive function and processing speed. The findings further characterize the relationship between TBI history and long-term cognitive sequelae in veterans, particularly suggesting LOC can affect neural systems underlying executive function and processing speed.