bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioengineered Neutrophils for Smart Response in Brain Infection Management
Authors: Zhou Anwei , Kong Delian , Zhou Xinyuan , Liu Yao , Zhang Yiping , Li Junrong , Xu Yurui , Ning Xinghai 
Published: January 2024

AbstractBrain infections, frequently accompanied by significant inflammation, necessitate comprehensive therapeutic approaches targeting both infections and associated inflammation. A major impediment to such combined treatment is the blood–brain barrier (BBB), which significantly restricts therapeutic agents from achieving effective concentrations within the central nervous system. Here, a neutrophil‐centric dual‐responsive delivery system, coined “CellUs,” is pioneered. This system is characterized by live neutrophils enveloping liposomes of dexamethasone, ceftriaxone, and oxygen‐saturated perfluorocarbon (Lipo@D/C/P). CellUs is meticulously engineered to co‐deliver antibiotics, anti‐inflammatory agents, and oxygen, embodying a comprehensive strategy against brain infections. CellUs leverages the intrinsic abilities of neutrophils to navigate through BBB, accurately target infection sites, and synchronize the release of Lipo@D/C/P with local inflammatory signals. Notably, the incorporation of ultrasound‐responsive perfluorocarbon within Lipo@D/C/P ensures the on‐demand release of therapeutic agents at the afflicted regions. CellUs shows considerable promise in treating Staphylococcus aureus infections in mice with meningitis, particularly when combined with ultrasound treatments. It effectively penetrates BBB, significantly eliminates bacteria, reduces inflammation, and delivers oxygen to the affected brain tissue, resulting in a substantial improvement in survival rates. Consequently, CellUs harnesses the natural chemotactic properties of neutrophils and offers an innovative pathway to improve treatment effectiveness while minimizing adverse effects.
Recent Advances in Cyclization Reactions of 1,6‐Enynes
Authors: Liu Jia‐Xuan , Xu Sheng‐Qi , Han Ya‐Ping , Liang Yong‐Min 
Published: January 2024

AbstractElaborated molecular architectures, specifically those bearing one or more carbon stereocenters, stand as an important class of carbocyclic and heterocyclic frameworks because they are frequently occurring core structures in numerous natural products and biologically active pharmaceutical molecules. Over the past few decades, the development of versatile synthetic approaches via cascade cyclization reactions of 1,6‐enynes for the construction of a series of fused and spiro compounds has been the focus of a great deal of research initiatives. These synthesis strategies are peculiarly fascinating in the context of the assembly of a wide array of pharmaceutical molecules, natural products, agrochemicals, and functional materials. In this review, recent developments in the transformations of 1,6‐enynes with diverse coupling reagents are summarized since 2018, which could be divided into five categories: 1) Introduction; 2) Transition metal catalyzed cyclization of 1,6‐enynes; 3) Metal‐free cyclization of 1,6‐enynes; 4) Visible‐light‐induced cyclization of 1,6‐enynes; 5) Electrocatalytic cyclization of 1,6‐enynes.
Employing Piezoelectric Mg2+‐Doped Hydroxyapatite to Target Death Receptor‐Mediated Necroptosis: A Strategy for Amplifying Immune Activation
Authors: Yang Jiani , Du Yaqian , Yao Yuanfei , Liao Yuanyu , Wang Bojun , Yu Xuefan , Yuan Kaikun , Zhang Yanqiao , He Fei , Yang Piaoping 
Published: January 2024

AbstractAlthough immunogenic cell death (ICD) inducers evidently enhance the effectiveness of immunotherapy, their potential is increasingly restricted by the development of apoptosis resistance in tumor cells, poor immunogenicity, and low T‐cell immune responsiveness. In this study, for the first time, piezoelectrically catalyzed Mg2+‐doped hydroxyapatite (Mg‐HAP) nanoparticles, which are coated with a mesoporous silica layer and loaded with ONC201 as an agonist to specifically target the death receptor DR5 on tumor cells, ultimately developing an Mg‐HAP@MS/ONC201 nanoparticle (MHMO NP) system, are engineered. Owing to its excellent piezoelectric properties, MHMO facilitates the release of a significant amount of reactive oxygen species and Ca2+ within tumor cells, effectively promoting the upregulation of DR5 expression and inducing tumor cell necroptosis to ultimately overcome apoptosis resistance. Concurrently, Mg2+ released in the tumor microenvironment promotes CD8+ T receptor activation in response to the antitumor immune reaction induced by ICD. Using RNA‐seq analysis, it is elucidated that MHMO can activate the NF‐κB pathway under piezoelectric catalysis, thus inducing M1‐type macrophage polarization. In summary, a dual‐targeting therapy system that targets both tumor cells and the tumor microenvironment under piezoelectric catalysis is designed. This system holds substantial potential for advancements in tumor immunotherapy.
Constructing Resilient Cross‐Linked Network Toward Stable All‐Solid‐State Lithium‐Sulfur Batteries
Authors: Zhu Xinxin , Jiang Wei , Wang Liguang , Lu Jun 
Published: January 2024

AbstractLithium‐sulfur batteries utilizing sulfide solid electrolytes hold considerable potential for achieving both high energy density and enhanced safety. However, the substantial volume changes experienced by sulfur during cycling result in mechanical stress accumulation, leading to mechanical degradation and thereby degrading overall electrochemical performance. In this study, a stress‐buffer strategy is proposed to address this challenge by engineering a mechanically resilient crosslinked structure for the composite sulfur cathode. This structure is accomplished through the integration of a highly flexible thermoplastic elastomer (ethylene vinyl acetate, EVA), which enables stress release during sulfur volume variations by the repeated stretching and shrinking of EVA, thereby maintaining stable ionic/electronic diffusion channels within the electrode. By virtue of the mechanically stable architecture, the stress evolution experienced by the entire sulfur electrode is substantially reduced, witnessing a remarkable decrease of ≈33.7%. Consequently, the S‐EVA composite cathode demonstrates exceptional electrochemical performance, especially cycling stability. Notably, the S‐EVA composite cathode, with a high loading of 7.5 mg cm−2, exhibits stable cycling performance close to 3.0 mAh cm−2 within 50 cycles. This work not only offers novel insights into mitigating the mechanical stress within the electrode but also paves the way for developing durable high‐performance all‐solid‐state batteries.
Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF3)2)] (with M=Cu, Ag and Au)
Authors: Simoens Andreas , Carì Gianluca , Ostrowska Sylwia , Cazin Catherine S. J. , Stevens Christian V. , Nolan Steven P. 
Published: January 2024

AbstractThe weak base method in continuous flow is currently one of the most sustainable and attractive approaches towards the synthesis of transition metal N‐heterocyclic carbene (NHC) complexes. Herein we broaden the scope of this method by using it to produce [M(IPr)(OC(H)(CF3)2)] complexes, including copper, silver, and gold. These compounds bear the alkoxide ligand within the coordination sphere of the catalysts, which can open up new ways to benefit from the unique properties offered by HFIP (1,1,1,3,3,3‐hexafluoroisopropanol) in catalysis, while minimizing the needed amount.
Microvessel barrier dysfunction in sinonasal inverted papilloma‐associated squamous cell carcinoma and its manifestation in dynamic contrast‐enhanced MRI
Authors: Xian Mu , Yu Jiaqi , Li Zheng , Piao Yingshi , Wang Chegnshuo , Xian Junfang , Zhang Luo 
Published: January 2024

AbstractBackgroundTo date, an effective means to preoperatively predict the malignant transformation of sinonasal inverted papilloma (SIP) remains lacking due to similarities in clinical appearance. This study aimed to retrospectively evaluate dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) parameters and microvessel structure in tumors with histologically confirmed SIP and inverted papilloma‐associated squamous cell carcinoma (IP‐SCC), as well as correlate DCE‐MRI findings with angiogenesis biomarkers.MethodsAbsolute quantitative DCE‐MRI parameters (Ktrans, Kep, Ve) based on the Tofts model and model‐free semi‐quantitative indices (Tpeak, WR, MaxSlope) of SIP (n = 22) and IP‐SCC (n = 20) were investigated. Regions of interest (ROIs) were oriented according to the tumor subsites in the surgical records. Micro‐vessel density (MVD) counts and tight junction protein (claudin‐5) expression were evaluated in tumor specimens obtained during surgery. Differences in the above data were compared between the two groups. Correlations between DCE‐MRI parameters and angiogenic biomarkers were analyzed.ResultsCompared with SIP specimens, IP‐SCC specimens were characterized by a significantly higher MVD and a leakier microvessel barrier. The values of Tpeak and Ve were significantly higher for SIP than those for IP‐SCC, whereas WR, MaxSlope, and Kep were significantly lower, indicating early enhancement and a faster dispersion model in IP‐SCC. MVD was positively correlated with WR and Kep and negatively correlated with Tpeak. Tpeak was slightly positively correlated to claudin‐5 expression.ConclusionDCE‐MRI can serve as a noninvasive biomarker of angiogenesis in the malignant transformation from SIP to IP‐SCC. DCE‐MRI may assist in the differentiation of malignancies and treatment selection.
Common infections and neuroimaging markers of dementia in three UK cohort studies
Authors: Green Rebecca E. , Sudre Carole H. , Warren‐Gash Charlotte , Butt Julia , Waterboer Tim , Hughes Alun D. , Schott Jonathan M. , Richards Marcus , Chaturvedi Nish , Williams Dylan M. 
Published: January 2024

AbstractINTRODUCTIONWe aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal volume, white matter lesions) across three population‐based studies.METHODSWe tested associations between serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) and outcomes using linear regression, including adjustments for total intracranial volume and scanner/clinic information (basic model), age, sex, ethnicity, education, socioeconomic position, alcohol, body mass index, and smoking (fully adjusted model). Interactions between serology measures and apolipoprotein E (APOE) genotype were tested. Findings were meta‐analyzed across cohorts (Nmain = 2632;NAPOE‐interaction = 1810).RESULTSSeropositivity to John Cunningham virus associated with smaller brain volumes in basic models (β = −3.89 mL [−5.81, −1.97],Padjusted < 0.05); these were largely attenuated in fully adjusted models (β = −1.59 mL [−3.55, 0.36],P = 0.11). No other relationships were robust to multiple testing corrections and sensitivity analyses, but several suggestive associations were observed.DISCUSSIONWe did not find clear evidence for relationships between common infections and markers of dementia risk. Some suggestive findings warrant testing for replication.
A Self‐Sustaining Near‐Infrared Afterglow Chemiluminophore for High‐Contrast Activatable Imaging
Authors: Zhu Jieli , Chen Wan , Yang Li , Zhang Yuyang , Cheng Baoliang , Gu Wei , Li Qing , Miao Qingqing 
Published: January 2024

AbstractAfterglow imaging holds great promise for ultrasensitive bioimaging due to its elimination of autofluorescence. Self‐sustaining afterglow molecules (SAMs), which enable all‐in‐one photon sensitization, chemical defect formation and afterglow generation, possess a simplified, reproducible, and efficient superiority over commonly used multi‐component systems. However, there is a lack of SAMs, particularly those with much brighter near‐infrared (NIR) emission and structural flexibility for building high‐contrast activatable imaging probes. To address these issues, this study for the first time reports a methylene blue derivative‐based self‐sustaining afterglow agent (SAN‐M) with brighter NIR afterglow chemiluminescence peaking at 710 nm. By leveraging the structural flexibility and tunability, an activatable nanoprobe (SAN‐MO) is customized for simultaneously activatable fluoro‐photoacoustic and afterglow imaging of peroxynitrite (ONOO−), notably with a superior activation ratio of 4523 in the afterglow mode, which is at least an order of magnitude higher than other reported activatable afterglow systems. By virtue of the elimination of autofluorescence and ultrahigh activation contrast, SAN‐MO enables early monitoring of the LPS‐induced acute inflammatory response within 30 min upon LPS stimulation and precise image‐guided resection of tiny metastatic tumors, which is unattainable for fluorescence imaging.
High Mobility Emissive Excimer Organic Semiconductor Towards Color‐Tunable Light‐Emitting Transistors
Authors: Xie Ziyi , Liu Dan , Zhao Zhennan , Gao Can , Wang Pu , Jiang Chuanxiu , Liu Xinfeng , Zhang Xiaotao , Ren Zhongjie , Yan Shouke , Hu Wenping , Dong Huanli 
Published: January 2024

AbstractOrganic light‐emitting transistors (OLETs) are highly integrated and minimized optoelectronic devices with significant potential superiority in smart displays and optical communications. To realize these various applications, it is urgently needed for color‐tunable emission in OLETs, but remains a great challenge as a result of the difficulty for designing organic semiconductors simultaneously integrating high carrier mobility, strong solid‐state emission, and the ability for potential tunable colors. Herein, a high mobility emissive excimer organic semiconductor, 2,7‐di(2‐anthryl)‐9H‐fluorene (2,7‐DAF) was reasonably designed by introducing a rotatable carbon–carbon single bond connecting two anthracene groups at the 2,7‐sites of fluorene, and the small torsion angles simultaneously guarantee effective conjugation and suppress fluorescence quenching. Indeed, the unique stable dimer arrangement and herringbone packing mode of 2,7‐DAF single crystal enables its superior integrated optoelectronic properties with high carrier mobility of 2.16 cm2 ⋅ V−1 ⋅ s−1, and strong excimer emission with absolute photoluminescence quantum yield (PLQY) of 47.4 %. Furthermore, the voltage‐dependent electrically induced color‐tunable emission from orange to blue was also demonstrated for an individual 2,7‐DAF single crystal based OLETs for the first time. This work opens the door for a new class of high mobility emissive excimer organic semiconductors, and provides a good platform for the study of color‐tunable OLETs.
Spiro[3.3]heptane as a Saturated Benzene Bioisostere**
Authors: Prysiazhniuk Kateryna , Datsenko Oleksandr P. , Polishchuk Oleksandr , Shulha Stanislav , Shablykin Oleh , Nikandrova Yelyzaveta , Horbatok Kateryna , Bodenchuk Iryna , Borysko Petro , Shepilov Dmytro , Pishel Iryna , Kubyshkin Vladimir , Mykhailiuk Pavel K. 
Published: January 2024

AbstractThe spiro[3.3]heptane core, with the non‐coplanar exit vectors, was shown to be a saturated benzene bioisostere. This scaffold was incorporated into the anticancer drug sonidegib (instead of the meta‐benzene), the anticancer drug vorinostat (instead of the phenyl ring), and the anesthetic drug benzocaine (instead of the para‐benzene). The patent‐free saturated analogs obtained showed a high potency in the corresponding biological assays.
Synthesis of a water‐soluble chain transfer agent and its application in gel dispersions
Authors: Zhang Xianli , Yang Ziteng , Liu Shanghao , Wang Jiaqin , Liu Siyuan , Bao Dan , Zhang Peng 
Published: January 2024

AbstractPre‐crosslinked gel particles, colloidal dispersion gels, and polymer microspheres are often used as profile‐controlling and flooding agents to displace residual crude oil from formations. The preparation process of these profile‐controlling and flooding agents is complicated. In order to simplify the preparation steps, a water‐soluble chain transfer (RAFT) agent, S,S′‐bis(2‐propionic acid) trithiocarbonate (PATTC), was synthesized, and then, hydrogel dispersions were prepared by one‐pot RAFT polymerization. The structure of PATTC was confirmed by infrared spectroscopy and nuclear magnetic resonance. The effects of reaction conditions on the viscosity and viscosity‐average molecular weight of hydrogel dispersions were explored, the rheology, viscoelasticity, particle size, temperature responsiveness, and salinity responsiveness of hydrogel dispersions were measured, and the seepage properties of hydrogel dispersions in porous medium were analyzed. The results show that at higher shear rates, the polyacrylamide gel dispersions exhibited Newtonian fluid characteristics. Viscoelasticity tests further confirmed that the polyacrylamide gel dispersions were successfully synthesized. The particle size of the hydrogel dispersions is 1–75 μm, its viscosity is less affected by temperature and salinity, and its residual resistance coefficient is higher than that of the polyacrylamide solution under similar apparent viscosity.
Teacher‐composed cases of practice as and for dissemination, reflection and data
Authors: Cowie Bronwen , Trask Suzanne , Edwards Frances 
Published: January 2024

AbstractThe need to make evidence and implications of educational research widely available has prompted a burgeoning interest in knowledge mobilisation, which is a set of strategies supporting the active and intentional dissemination of research knowledge. For this, it is important to consider who might be the intended audience and end‐users of this knowledge, as this impacts decisions throughout the research process. Researcher–teacher collaborations are effective contexts for knowledge‐building and sharing, where both partners have different but equally valuable roles and contributions to make to the conduct, analysis and dissemination of research. This paper illustrates the value and uses of teacher‐composed written and video cases of colleague coaching. The cases were generated as part of the Zooming project, a seven‐school, 3‐year research–practice partnership focused on developing teachers' data literacy and capacity to coach colleagues in this. To craft the cases, the teachers reflected on their coaching practices and relationships and identified what would be most useful for new coaches to know. The cases proved to be engaging tools for research dissemination, especially to a professional audience. In addition, the case writing challenged teachers to reflect on and analyse their coaching actions and the assumptions they brought to collegial coaching. The cases as data also provided researchers with a deeper level of insights into what teachers viewed as salient when coaching colleagues in data use. Teacher case composition offers a useful approach to knowledge co‐production and a pathway to research dissemination by and for teachers and researchers.
The logic of protein post‐translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments
Authors: Suskiewicz Marcin J. 
Published: January 2024

AbstractProtein post‐translational modifications (PTMs) play a crucial role in all cellular functions by regulating protein activity, interactions and half‐life. Despite the enormous diversity of modifications, various PTM systems show parallels in their chemical and catalytic underpinnings. Here, focussing on modifications that involve the addition of new elements to amino‐acid sidechains, I describe historical milestones and fundamental concepts that support the current understanding of PTMs. The historical survey covers selected key research programmes, including the study of protein phosphorylation as a regulatory switch, protein ubiquitylation as a degradation signal and histone modifications as a functional code. The contribution of crucial techniques for studying PTMs is also discussed. The central part of the essay explores shared chemical principles and catalytic strategies observed across diverse PTM systems, together with mechanisms of substrate selection, the reversibility of PTMs by erasers and the recognition of PTMs by reader domains. Similarities in the basic chemical mechanism are highlighted and their implications are discussed. The final part is dedicated to the evolutionary trajectories of PTM systems, beginning with their possible emergence in the context of rivalry in the prokaryotic world. Together, the essay provides a unified perspective on the diverse world of major protein modifications.
Revisiting the Latin vocabulary of Terminologia Histologica: I. Nouns
Authors: Neumann Paul E. , Houle Mélanie , Russell Stephen , Stiles Lewis , Ottone Nicolás E. , del Sol Mariano 
Published: January 2024

AbstractAlmost 20% of the Latin nouns (193/993) in Terminologia Histologica (TH), the international standard nomenclature for human histology and cytology, display linguistic problems, particularly in the areas of orthography, gender, and declension. Some anatomists have opposed efforts to restore the quality of the Latin nomenclature as pedantry, preferring to create or modify Latin words so that they resemble words in English and other modern languages. A Latin microanatomical nomenclature is vulnerable to the criticism of anachronism, so the requirement for the use of authentic Latin, including derivation of new words from Greek and Latin words rather than from modern languages, if possible, may be even greater than it is for the anatomical nomenclature. The most common problem identified here appears to have been caused by derivation of Latin nouns by addition of ‐us and ‐um second declension endings to English words. Many Latin nouns (128) in TH contain one of six morphemes that have been treated this way even though the original Greek words are either first declension masculine or third declension neuter nouns. Ironically, deriving Latin nouns directly from Greek morphemes often results in words that look more familiar to speakers of Romance and Germanic languages than those derived indirectly through modern languages (e.g., astrocyte, collagene, dendrita, lipochroma, osteoclasta and telomere instead of astrocytus, collagenum, dendritum, lipochromum, osteoclastus, and telomerus).