bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinspired Hollow/Hollow Architecture with Flourishing Dielectric Properties for Efficient Electromagnetic Energy Reclamation Device
Authors: Meng Xiangwei , Qiao Jing , Liu Jiurong , Wu Lili , Wang Zhou , Wang Fenglong 
Published: October 2023

AbstractThe exploitation of advanced electromagnetic functional devices is perceived as the effective prescription to deal with environmental contamination and energy deficiency. From the perspective of observing and imitating nature, pine branch‐like zirconium dioxide/cobalt nanotubes@nitrogen‐doped carbon nanotubes are synthesized victoriously through maneuverable electrospinning process and follow‐up thermal treatments. In particular, introducing carbon nanotubes on the surface of hollow nanofibers to construct hierarchical architecture vastly promoted the material's dielectric properties by significantly augmenting specific surface area, generating abundant heterogeneous interfaces, and inducing the formation of defects. Supplemented by the synergistic effect between each constituent, ultra‐strong attenuation capacity and perfect impedance matching characteristics are implemented simultaneously, and jointly made contributions to the splendid microwave absorption performance with a minimum reflection loss of −67.9 dB at 1.5 mm. Moreover, this fibrous absorber also exhibited promising potential to be utilized as a green and efficient electromagnetic interference shielding material when the filler loading is enhanced. Therefore, this design philosophy is destined to inspire the future development of energy conversion and storage devices, and provide theoretical direction for the creation of sophisticated electromagnetic functional materials.
Dieckol prevents prostate cancer cell proliferation by transcriptionally attenuating JAK/STAT3 signaling pathway
Authors: Karuppaiya Vimala , Annamalai Asaikkutti , Krishnamurthy Shanthi , Soundarapandian Kannan 
Published: October 2023

AbstractThis study delved at how the natural substance dieckol (DCL) prevents prostate cancerous cells from proliferating and migrating by blocking the JAK/STAT3 signaling pathway in PC‐3 cells. For numerous tests, the cells were treated to DCL at a range of concentrations (0–20 μM) for 24 h. DCL mediated cytotoxicity was analyzed by MTT assay. To evaluate ROS, DCFH‐DA staining was employed. Dual (AO/EtBr) staining was utilized to examine apoptotic changes, and MMP levels in PC‐3 cells were examined using the appropriate fluorescent staining assays. By using flow cytometry and western blotting, the protein expressions of cell survival, cell cycle, proliferation, and apoptosis were assessed. The results showed that DCL significantly cytotoxically affects PC‐3, and the IC50 was discovered to be 12 μM for 24 h exposure. Furthermore, after DCL treatment in PC‐3, considerable ROS generation and increased apoptotic signals were detected. STAT3, JAK1, PCNA, and cyclins D1 and E1 are all suppressed by DCL in PC‐3. In addition, DCL therapy in PC‐3 dramatically increased pro‐apoptotic proteins such Bax, caspase‐3, and cytochrome C. Therefore, DCL has been regarded as a chemotherapeutic agent because to its ability to decrease the expression of proteins that control cell proliferation, including STAT3, JAK1, PCNA, and cyclins D1 and E1.
Symbol alphabets from the Landau singular locus
Authors: Dlapa Christoph , Helmer Martin , Papathanasiou Georgios , Tellander Felix 
Published: October 2023

Abstract
We provide evidence through two loops, that rational letters of polylogarithmic Feynman integrals are captured by the Landau equations, when the latter are recast as a polynomial of the kinematic variables of the integral, known as the principal A-determinant. Focusing on one loop, we further show that all square-root letters may also be obtained, by re-factorizing the principal A-determinant with the help of Jacobi identities. We verify our findings by explicitly constructing canonical differential equations for the one-loop integrals in both odd and even dimensions of loop momenta, also finding agreement with earlier results in the literature for the latter case. We provide a computer implementation of our results for the principal A-determinants, symbol alphabets and canonical differential equations in an accompanying Mathematica file. Finally, we study the question of when a one-loop integral satisfies the Cohen-Macaulay property and show that for almost all choices of kinematics the Cohen-Macaulay property holds. Throughout, in our approach to Feynman integrals, we make extensive use of the Gel’fand, Graev, Kapranov and Zelevinskiĭ theory on what are now commonly called GKZ-hypergeometric systems whose singularities are described by the principal A-determinant.
Anthropocene isostatic adjustment on an anelastic mantle
Authors: Ivins Erik R. , Caron Lambert , Adhikari Surendra 
Published: October 2023

AbstractA general assumption in geodesy is that solid Earth deformation in the presence of recent hydrological and ice loading is well approximated by a purely elastic response. In cases where there is clear evidence that thermal and petrological conditions exist that favor vigorous high-temperature creep behavior, such as in the mantle beneath Iceland, Patagonia, Alaska, Japan, and Svalbard, many response models have been approximated by using a Maxwell viscoelasticity. However, non-Maxwellian transient viscoelastic rheology is required for many post-seismic relaxation studies. Here, we reconsider the solid Earth response in light of highly temperature-dependent transient viscoelastic responses currently favored in the mineral physics and seismological communities. We develop a mantle response Green’s function that accounts for the vertical isostatic motion of the mantle caused by the acceleration of ice mass loss for Greenland and Patagonia measured by spaceborne and airborne remote sensing since 1992 and 1945, respectively. The Green’s function may be used to examine how anelasticity influences the uplift associated with accelerated surface mass loss. We perform a parameter exploration of the constants that define the Extended Burgers Material model, a rheology having firm experimental and theoretical underpinnings, in order to isolate those material model parameters that have the greatest impact on anelastic-isostatic uplift over interannual and interdecadal timescales. Anelasticity corrections may be required for solid Earth vertical uplift in space gravimetric solutions for long-term hydrology and cryospheric change.
Risk factors for acute kidney injury associated with intravenous vancomycin in neurosurgical inpatients: a retrospective study
Authors: Lu Ruqi , Ren Junli , Zhou Xuanping , Zheng Bin , Peng Fangchen 
Published: October 2023

Abstract
Purpose
Vancomycin (VAN) is widely used in neurosurgical patients for intracranial infections. We aimed to assess the incidence and risk factors for VAN-associated acute kidney injury (VA-AKI) in this population.

Methods
A case–control study of patients who treated with vancomycin in neurosurgery from January 2020 to December 2022 was conducted. Demographics and potential risk factors were collected. Multivariate logistic regression analyses were performed to identify risk factors for VA-AKI. AKI was defined according to the Kidney Disease Improving Global Outcomes Guidelines (KDIGO).

Results
A total of 345 patients participated with a VA-AKI incidence of 17.1% (59 cases). Among them, 15 patients had renal impairment (Stage 2 or higher), and 2 required dialysis. With univariate analysis and binary logistic regression analysis, we found that the use of mannitol (OR: 4.164; 95% CI: 1.606–10.792; P = 0.003), loop diuretics (OR: 3.371; 95% CI: 1.633–6.958; P = 0.001), three or more antimicrobial applications (OR: 3.623; 95% CI: 1.600–8.206; P = 0.002), diastolic blood pressure 80–89 mm Hg (OR: 5.532; 95% CI: 1.677–18.250; P = 0.005) and diastolic blood pressure ≥ 90 mm Hg (OR: 6.845; 95% CI: 1.518–30.866; P = 0.012) were independent risk factors for VA-AKI. In addition, according to the Youden Index, the trough concentration of vancomycin should not exceed 15.845 mg/L.

Conclusion
The incidence of VA-AKI in neurosurgical patients was 17.1%. The concomitant use of mannitol and loop diuretics, along with higher diastolic blood pressure and the combined use of more than three antimicrobial agents, were associated with an increased risk of neurosurgical VA-AKI.
More Than a Service: Values of Rivers, Wetlands and Floodplains Are Informed by Both Function and Feeling
Authors: Campbell Cherie J. , Lovett Siwan , Capon Samantha J. , Thompson Ross M. , Dyer Fiona J. 
Published: October 2023

AbstractHow people value rivers, wetlands and floodplains influences their attitudes, beliefs and behaviours towards these ecosystems, and can shape policy and management interventions. Better understanding why people value rivers, wetlands and floodplains and their key ecosystem components, such as vegetation, helps to determine what factors underpin the social legitimacy required for effective management of these systems. This study sought to ascertain perspectives on the value of non-woody vegetation in river-floodplain systems via an online survey. The survey found that participants valued non-woody vegetation for their provision of a range of ecosystem functions and services, with strong emphasis on ecological aspects such as regulation functions, habitat provision and biodiversity. However, the inclusion of a question framed to focus on stories or narratives resulted in a different emphasis. Responses indicated that non-woody vegetation, and rivers, wetlands and floodplains were valued for the way they made people feel through lived experiences such as recreational activities, personal interactions with nature, educational and research experiences. This highlights the important role of storytelling in navigating complex natural resource management challenges and ascertaining a deeper understanding of values that moves beyond provision of function to feeling. Improved understanding of the diverse ways people value and interact with river-floodplain systems will help develop narratives and forms of engagement that foster shared understanding, empathy and collaboration. Appreciation of plural values such as the provision of functions and services along with the role of emotional connections and lived experience will likely increase lasting engagement of the general public with management to protect and restore river-floodplain systems.
Sudden cardiac arrest in infants and children: proposal for a diagnostic workup to identify the etiology. An 18-year multicenter evaluation in the Netherlands
Authors: Bakker Ashley M. , Albrecht Marijn , Verkaik Bas J. , de Jonge Rogier C. J. , Buysse Corinne M. P. , Blom Nico A. , Rammeloo Lukas A. J. , Verhagen Judith M. A. , Riedijk Maaike A. , Yap Sing C. , Tan Hanno L. , Kammeraad Janneke A. E. 
Published: October 2023

AbstractSudden cardiac arrest (SCA) studies are often population-based, limited to sudden cardiac death, and excluding infants. To guide prevention opportunities, it is essential to be informed of pediatric SCA etiologies. Unfortunately, etiologies frequently remain unresolved. The objectives of this study were to determine paediatric SCA etiology, and to evaluate the extent of post-SCA investigations and to assess the performance of previous cardiac evaluation in detecting conditions predisposing to SCA. In a retrospective cohort (2002–2019), all children 0–18 years with out-of-hospital cardiac arrest (OHCA) referred to Erasmus MC Sophia Children's Hospital or the Amsterdam UMC (tertiary-care university hospitals), with cardiac or unresolved etiologies were eligible for inclusion. SCA etiologies, cardiac and family history and etiologic investigations in unresolved cases were assessed. The etiology of arrest could be determined in 52% of 172 cases. Predominant etiologies in children ≥ 1 year (n = 99) were primary arrhythmogenic disorders (34%), cardiomyopathies (22%) and unresolved (32%). Events in children < 1 year (n = 73) were largely unresolved (70%) or caused by cardiomyopathy (8%), congenital heart anomaly (8%) or myocarditis (7%). Of 83 children with unresolved etiology a family history was performed in 51%, an autopsy in 51% and genetic testing in 15%. Pre-existing cardiac conditions presumably causative for SCA were diagnosed in 9%, and remained unrecognized despite prior evaluation in 13%.Conclusion: SCA etiology remained unresolved in 83 of 172 cases (48%) and essential diagnostic investigations were often not performed. Over one-fifth of SCA patients underwent prior cardiac evaluation, which did not lead to recognition of a cardiac condition predisposing to SCA in all of them. The diagnostic post-SCA approach should be improved and the proposed standardized pediatric post-SCA diagnostics protocol may ensure a consistent and systematic evaluation process increasing the diagnostic yield.

What is Known:• Arrests in infants remain unresolved in most cases. In children > 1 year, predominant etiologies are primary arrhythmia disorders, cardiomyopathy and myocarditis.• Studies investigating sudden cardiac arrest are often limited to sudden cardiac death (SCD) in 1 to 40 year old persons, excluding infants and successfully resuscitated children.

What is New:• In patients with unresolved SCA events, the diagnostic work up was often incompletely performed.• Over one fifth of victims had prior cardiac evaluation before the arrest, with either a diagnosed cardiac condition (9%) or an unrecognized cardiac condition (13%).

Graphical Abstract
A qualitative exploration of the dynamics of guilt experience in family cancer caregivers
Authors: Mohamed Hussin Nur Atikah , Mohd Sabri Nursahira Sahiba 
Published: October 2023

AbstractCaregiving for cancer patients can cause stress among family caregivers. Caregiving stress is also associated with guilt as they cannot provide adequate care for cancer patients. However, guilt among family caregivers of cancer patients is poorly understood. This qualitative study aimed to explore the dynamics of guilt feelings in families that care for cancer patients. This study involved 45 family caregivers of cancer patients. Thematic data analysis was conducted. There were six themes emerging. Caregiving can be challenging, guilt and blame, guilt due to lack of self-capacity, guilt for neglecting others, no guilt at all, and discussion of guilt and blame as a caregiver. This study offers insight into social workers regarding the challenges and experiences faced by family caregivers of cancer patients. Appropriate health interventions and support should be provided to family caregivers of cancer patients to improve their well-being.
Universities, heritage, and non-museum institutions: a methodological proposal for sustainable documentation
Authors: Salse-Rovira Marina , Jornet-Benito Nuria , Guallar Javier , Mateo-Bretos Maria Pilar , Silvestre-Canut Josep Oriol 
Published: October 2023

AbstractTo provide a sustainable methodology for documenting the small (and underfunded) but often important university heritage collections. The sequence proposed by the DBLC (Database Life Cycle) (Coronel and Morris, Database Systems: Design, Implementation, & Management. Cengage Learning, Boston, 2018; Oppel Databases a beginner’s guide. McGraw-Hill, New York, 2009) is followed, focusing on the database design phase. The resulting proposals aim at harmonising the different documentation tools developed by GLAM institutions (acronym that aims to highlight the common aspects of Galleries, Libraries, Archives and Museums), all of which are present in the university environment. The work phases are based mainly on the work of Valle, Fernández Cacho, and Arenillas (Muñoz Cruz et al. Introducción a la documentación del patrimonio cultural. Consejería de Cultura de la Junta de Andalucía, Seville, 2017), combined with the experience acquired from the creation of the virtual museum at our institution. The creation of a working team that includes university staff members is recommended because we believe that universities have sufficient power to manage their own heritage. For documentation, we recommend the use of application profiles that consider the new trends in semantic web and LOD (Linked Open Data) and that are created using structural interchange standards such as Dublin Core, LIDO, or Darwin Core, which should be combined with content and value standards adapted from the GLAM area. The application of the methodology described above will make it possible to obtain quality metadata in a sustainable way given the limited resources of university collections. A proposed metadata schema is provided as an annex.
Clinical advances in immunotherapy for immune-mediated glomerular diseases
Authors: Tang Bihui , Yang Xiao 
Published: October 2023

Abstract
Background and objective
Due to the suboptimal therapeutic efficacy and potential adverse effects associated with traditional immunosuppressive medications, there has been an increasing emphasis on the development and utilization of immunotherapies. This paper aims to provide clinicians with valuable insights for selecting appropriate therapeutic approaches and contribute to the development of novel immunotherapeutic drugs.

Main body
This paper categorizes the immunotherapeutic drugs that are used for the treatment of immune-mediated glomerular diseases into three groups: immunotherapies targeting antigen-presenting cells (anti-CD80), immunotherapies targeting T/B cells (anti-CD20, anti-CD22, BAFF and APRIL inhibitors, CD40-CD40L inhibitors, proteasome inhibitors, Syk inhibitors, and Btk inhibitors), and immunotherapies targeting the complement system (C5 inhibitors, C5a/C5aR inhibitors, C3 inhibitors, MASP2 inhibitors, factor B inhibitors, and factor D inhibitors). The article then provides a comprehensive overview of advances related to these immunotherapeutic drugs in clinical research.

Conclusion
Certain immunotherapeutic drugs, such as rituximab, belimumab, and eculizumab, have exhibited notable efficacy in treating specific immune-mediated glomerular diseases, thereby providing novel therapeutic approaches for patients. Nonetheless, the efficacy of numerous immunotherapeutic drugs remains to be substantiated.
Stochastic modeling of the receiver clock parameter in Galileo-only and multi-GNSS PPP solutions
Authors: Mikoś Marcin , Kazmierski Kamil , Hadas Tomasz , Sośnica Krzysztof 
Published: October 2023

AbstractIn Precise Point Positioning (PPP), the receiver clock parameter is typically estimated independently in each observation epoch, which increases the noise of the estimated station coordinates and troposphere parameters due to correlations. Applying stochastic modeling to the receiver clock parameter stabilizes PPP solutions and reduces clock noise for the time transfer. However, the receiver clock modeling is possible only for the GNSS receivers connected to the utmost stable atomic clocks. We propose receiver clock modeling that involves the Markov stochastic process in the form of a random walk. We test different levels of random walk constraints for GNSS stations equipped with different types of clocks for Galileo-only and multi-GNSS solutions in kinematic and static PPP. In multi-GNSS solutions, the common clock parameter is derived with inter-system biases (ISBs). This raises the question of the constraints that should be imposed on the common clock only or also on the ISBs. We found that similar results can be achieved by imposing constraints on the common clock parameter and estimating ISB as a constant parameter and when constraining the common clock parameter and ISBs with a ratio of 1:100. Other ratios of clock-to-ISB constraints, such as 1:1 and 1:10, give inferior results. In the kinematic PPP, stochastic clock modeling has a marginal impact on the North and East coordinate components, whereas the Up component is substantially improved for GNSS receivers equipped with hydrogen masers. In the static PPP, the clock modeling improves the time transfer, due to the reduced noise of the clocks.
Computation of flow rates in rarefied gas flow through circular tubes via machine learning techniques
Authors: Sofos F. , Dritselis C. , Misdanitis S. , Karakasidis T. , Valougeorgis D. 
Published: October 2023

AbstractKinetic theory and modeling have been proven extremely suitable in computing the flow rates in rarefied gas pipe flows, but they are computationally expensive and more importantly not practical in design and optimization of micro- and vacuum systems. In an effort to reduce the computational cost and improve accessibility when dealing with such systems, two efficient methods are employed by leveraging machine learning (ML). More specifically, random forest regression (RFR) and symbolic regression (SR) have been adopted, suggesting a framework capable of extracting numerical predictions and analytical equations, respectively, exclusively derived from data. The database of the reduced flow rates W used in the current ML framework has been obtained using kinetic modeling and it refers to nonlinear flows through circular tubes (tube length over radius $$l \in [0,5]$$

l
∈
[
0
,
5
]

and downstream over upstream pressure $$p \in [0,0.9]$$

p
∈
[
0
,
0.9
]

) in a very wide range of the gas rarefaction parameter $$\delta \in [0,10^3]$$

δ
∈
[
0
,

10
3

]

. The accuracy of both RFR and SR models is assessed using statistical metrics, as well as the relative error between the ML predictions and the kinetic database. The predictions obtained by RFR show very good fit on the simulation data, having a maximum absolute relative error of less than $$12.5\%$$

12.5
%

. Various expressions of the form of $$W=W(p,l,\delta )$$

W
=
W
(
p
,
l
,
δ
)

with different accuracy and complexity are acquired from SR. The proposed equation, valid in the whole range of the relevant parameters, exhibits a maximum absolute relative error less than $$17\%$$

17
%

. To further improve the accuracy, the dataset is divided into three subsets in terms of $$\delta$$
δ
and one SR-based closed-form expression of each subset is proposed, achieving a maximum absolute relative error smaller than $$9\%$$

9
%

. Very good performance of all proposed equations is observed, as indicated by the obtained accuracy measures. Overall, the present ML-predicted data may be very useful in gaseous microfluidics and vacuum technology for engineering purposes.
Synthesis and applications of cyclonucleosides: an update (2010–2023)
Authors: Burchiellaro Katherine , Mieczkowski Adam 
Published: October 2023

AbstractCyclonucleosides are a group of nucleoside derivatives which, in addition to the classical N-glycosidic bond, have an additional covalent bond (linker, bridge) in their structure, which connects the heterocyclic base and sugar ring. The majority of them have been discovered in the laboratory; however, few such compounds have also been found in natural sources, including metabolites of sponges or radical damage occurring in nucleic acids. Due to their structural properties—rigid, fixed conformation—they have found wide applications in medicinal chemistry and biochemistry as biocides as well as enzyme inhibitors and molecular probes. They have also found use as convenient synthetic tools for the preparation of new nucleoside analogues, enabling structural modifications of both the sugar ring and heterocyclic base. This review summarizes the recent progress in the synthesis of various purine and pyrimidine cyclonucleosides using diverse chemical approaches based on radical, “click”, metal-mediated, and other types of reactions. It also presents recent reports concerning possible applications in medicinal chemistry, as well as their applications as valuable key intermediates in the synthesis of sugar- and base-modified nucleoside analogues and heterocyclic compounds.
Graphical abstract