bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo assessment of black seed oil single dose on prednisolone pharmacokinetics
Authors: Abutaima Rana , Al-ebini Yousef , Alkofahi Ahmad , Alshishani Anas , Thiab Samar , Alagammai Kumarappan C , Khalid Mohammad 
Published: November 2023

Abstract

Objectives
To investigate the effect of blackseed oil (BSO) single dose on prednisolone pharmacokinetics via p-gp inhibition.

Methods
Three groups of rats (n = 5) were orally administered the vehicle, verapamil (50 mg/kg) or BSO (5 ml/kg) 15 min prior to prednisolone (5 mg/kg) administration. Blood samples were collected over 24 h and quantified. Non-compartmental analysis was employed to calculate maximum plasma concentration (Cmax), area under the curve (AUC0-last), time to reach Cmax (Tmax), apparent clearance (CL/F), and half-life (t1/2). Statistical significance was considered at p&lt;0.05.

Results
Prednisolone Cmax and AUC0-last decreased by 65% and 25% in the BSO group compared to the negative control (P &lt; .0001, .0029, respectively) while they increased by 1.75-folds and 8-folds in verapamil group (P &lt; .0001). Tmax was achieved at 0.16, 0.5, and 0.25 h in the negative control, verapamil, and BSO-treated groups, respectively. CL/F in the treatment group was 1.3-fold and 10-fold higher compared to the negative and positive control, respectively, whereas the t1/2 remained comparable.

Conclusion
Administration of BSO decreased prednisolone Cmax and AUC0-last in rats indicating that there is a herb-drug interaction; however, p-gp inhibition cannot be concluded. Patients relying on folk medicine in chronic illnesses treatment might need to avoid combining BSO with prednisolone.
Communal Minute Books: Writing, Ethnography, and History of the War in Peru in the 1980s
Authors: Del Pino Huamán Ponciano 
Published: November 2023

Abstract
This article addresses how Peruvian highland society constructed a local history of the Shining Path war through its responses as well as the recording (and non-recording) of events in communal minute books. Through three case studies of communities in the mid-1980s in Ayacucho, it assesses the cultural and political reach of writing in the production of communal historical knowledge, narratives of the past, and collective identity. The writing of and in community minute books configures the boundaries of the war narrative within these locales, particularly during the crucial period referred to in Quechua as tikrakuy, when communities changed their allegiance and went from supporting the insurgency to fighting it. During and after tikrakuy, a great part of the civilian population openly chose a side and intervened in the war, engaging in acts of violence. This article studies how the foundational violence of tikrakuy led to the emergence of a new political formation and social order. It also broadens the discussion on the participation of the civilian population in the war and its place in wartime collective violence.
Bayesian Integration of Probability and Nonprobability Samples for Logistic Regression
Authors: Salvatore Camilla , Biffignandi Silvia , Sakshaug Joseph W , Wiśniowski Arkadiusz , Struminskaya Bella 
Published: November 2023

Abstract
Probability sample (PS) surveys are considered the gold standard for population-based inference but face many challenges due to decreasing response rates, relatively small sample sizes, and increasing costs. In contrast, the use of nonprobability sample (NPS) surveys has increased significantly due to their convenience, large sample sizes, and relatively low costs, but they are susceptible to large selection biases and unknown selection mechanisms. Integrating both sample types in a way that exploits their strengths and overcomes their weaknesses is an ongoing area of methodological research. We build on previous work by proposing a method of supplementing PSs with NPSs to improve analytic inference for logistic regression coefficients and potentially reduce survey costs. Specifically, we use a Bayesian framework for inference. Inference relies on a probability survey with a small sample size, and through the prior structure we incorporate supplementary auxiliary information from a less-expensive (but potentially biased) NPS survey fielded in parallel. The performance of several strongly informative priors constructed from the NPS information is evaluated through a simulation study and real-data application. Overall, the proposed priors reduce the mean-squared error (MSE) of regression coefficients or, in the worst case, perform similarly to a weakly informative (baseline) prior that does not utilize any nonprobability information. Potential cost savings (of up to 68 percent) are evident compared to a probability-only sampling design with the same MSE for different informative priors under different sample sizes and cost scenarios. The algorithm, detailed results, and interactive cost analysis are provided through a Shiny web app as guidance for survey practitioners.
Evaluating WIC Engagement and Food Insecurity Among Active Duty Military Families
Authors: Zven Sidney E , Graziose Brian , Smith Kristen , Sorensen Ian , Hisle-Gorman Elizabeth , Chokshi Binny 
Published: November 2023

ABSTRACT

Introduction
Nearly a quarter of active duty service members identified as food insecure in a 2022 Department of Defense report. Food insecurity impacts military readiness, retention, and recruitment. The Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a federal food supplementation program that can mitigate food insecurity for service members with children less than 5 years of age. To date, there is a lack of standardized screening for WIC eligibility or enrollment for service members and their families. This project sought to evaluate WIC awareness and enrollment as well as the prevalence of food insecurity at Walter Reed National Military Medical Center.

Materials and Methods
A 26-question survey was developed to assess WIC awareness, source of WIC information, food insecurity, and nutritional insecurity. Our team developed and utilized a novel WIC screening algorithm to rapidly screen families for WIC eligibility. These tools were administered to families presenting for care at the Walter Reed National Military Medical Center pediatrics and obstetric outpatient clinics during the month of July 2022. This study was approved by the institutional review board at Walter Reed.

Results
A total of 108 (25%) of the 432 surveyed participants were eligible for WIC, with odds of WIC eligibility increasing for lower-ranking and younger service members. Of the 432 participants, 354 (81.9%) were aware of WIC. Enlisted service members were more likely than officers to know about WIC (P = 0.03), and of the 354 participants aware of WIC, a higher proportion of enlisted rank respondents learned about WIC from a military source (P = 0.01). Among the 108 participants eligible for WIC, only 38 (35.2%) reported being enrolled in WIC. Among WIC-eligible respondents who knew about WIC, being enrolled in the WIC program was not associated with rank, branch of service, sponsor gender, or sponsor age.

Conclusions
Despite proven efficacy, WIC remains an underutilized resource for eligible military families. Our results show that a standardized screening approach at Walter Reed National Military Medical Center increased identification of WIC-eligible active duty service members by 180%, with approximately $150,000 a year in increased food supplementation benefits. Military healthcare and readiness leaders should embrace efforts to increase knowledge of, referral to, and enrollment in WIC to increase family health, well-being, and military family readiness.
Characterizing X-ray, UV, and optical variability in NGC 6814 using high-cadence Swift observations from a 2022 monitoring campaign
Authors: Gonzalez A G , Gallo L C , Miller J M , Kammoun E S , Ghosh A , Pottie B A 
Published: November 2023

ABSTRACT
We present the first results of a high-cadence Swift monitoring campaign (3–4 visits per day for 75 d) of the type 1.5 Seyfert galaxy NGC 6814 characterizing its variability throughout the X-ray and ultraviolet (UV)/optical wavebands. Structure function analysis reveals an X-ray power law ($\alpha =0.5^{+0.2}_{-0.1}$) that is significantly flatter than the one measured in the UV/optical bands (〈α〉 ≈ 1.5), suggesting different physical mechanisms driving the observed variability in each emission region. The structure function break-time is consistent across the UV/optical bands (〈τ〉 ≈ 2.3 d), suggesting a very compact emission region in the disc. Correlated short time-scale variability measured through cross-correlation analysis finds a lag–wavelength spectrum that is inconsistent with a standard disc reprocessing scenario (τ ∝ λ4/3) due to significant flattening in the optical wavebands. Flux–flux analysis finds an extremely blue active galactic nucleus (AGN) spectral component (Fν ∝ λ−0.85) that does not follow a standard accretion disc profile (Fν ∝ λ−1/3). While extreme outer disc truncation (Rout = 202 ± 5 rg) at a standard accretion rate ($\dot{m}_{\mathrm{Edd}}=0.0255\pm 0.0006$) may explain the shape of the AGN spectral component, the lag–wavelength spectrum requires more modest truncation ($R_{\mathrm{out}}=1382^{+398}_{-404}\,r_g$) at an extreme accretion rate ($\dot{m}_{\mathrm{Edd}}=1.3^{+2.1}_{-0.9}$). No combination of parameters can simultaneously explain both results in a self-consistent way. Our results point towards the possibility of a non-standard disc geometry in NGC 6814.
On the possibility to detect gravitational waves from post-merger supermassive neutron stars with a kilohertz detector
Authors: Chen Yikang , Liu Bin , Ai Shunke , Lan Lin , Gao He , Yuan Yong , Zhu Zong-Hong 
Published: November 2023

ABSTRACT
The detection of a secular post-merger gravitational wave (GW) signal in a binary neutron star (BNS) merger serves as strong evidence for the formation of a long-lived post-merger neutron star (NS), which can help constrain the maximum mass of NSs and differentiate NS equations of state. We specifically focus on the detection of GW emissions from rigidly rotating NSs formed through BNS mergers, using several kilohertz GW detectors that have been designed. We simulate the BNS mergers within the detecting limit of LIGO-Virgo-KARGA O4 and attempt to find out on what fraction the simulated sources may have a detectable secular post-merger GW signal. For kilohertz detectors designed in the same configuration of LIGO A+, we find that the design with peak sensitivity at approximately 2 kHz is most appropriate for such signals. The fraction of sources that have a detectable secular post-merger GW signal would be approximately $0.94{\!-\!}11~{{ \rm per\ cent}}$ when the spin-downs of the post-merger rigidly rotating NSs are dominated by GW radiation, while it would be approximately $0.46{\!-\!}1.6~{{ \rm per\ cent}}$ when the contribution of electromagnetic (EM) radiation to the spin-down processes is non-negligible. We also estimate this fraction based on other well-known proposed kilohertz GW detectors and find that, with advanced design, it can reach approximately $12{\!-\!}45~{{ \rm per\ cent}}$ for the GW-dominated spin-down case and $4.7{\!-\!}16~{{\rm per\ cent}}$ when both the GW and EM radiations are considered.
Parallel Nonfunctionalization of CK1δ/ε Kinase Ohnologs Following a Whole-Genome Duplication Event
Authors: Evans-Yamamoto Daniel , Dubé Alexandre K , Saha Gourav , Plante Samuel , Bradley David , Gagnon-Arsenault Isabelle , Landry Christian R 
Published: November 2023

Abstract
Whole-genome duplication (WGD) followed by speciation allows us to examine the parallel evolution of ohnolog pairs. In the yeast family Saccharomycetaceae, HRR25 is a rare case of repeated ohnolog maintenance. This gene has reverted to a single copy in Saccharomyces cerevisiae where it is now essential, but has been maintained as pairs in at least 7 species post-WGD. In S. cerevisiae, HRR25 encodes the casein kinase 1δ/ε and plays a role in a variety of functions through its kinase activity and protein–protein interactions (PPIs). We hypothesized that the maintenance of duplicated HRR25 ohnologs could be a result of repeated subfunctionalization. We tested this hypothesis through a functional complementation assay in S. cerevisiae, testing all pairwise combinations of 25 orthologs (including 7 ohnolog pairs). Contrary to our expectations, we observed no cases of pair-dependent complementation, which would have supported the subfunctionalization hypothesis. Instead, most post-WGD species have one ohnolog that failed to complement, suggesting their nonfunctionalization or neofunctionalization. The ohnologs incapable of complementation have undergone more rapid protein evolution, lost most PPIs that were observed for their functional counterparts and singletons from post-WGD and non-WGD species, and have nonconserved cellular localization, consistent with their ongoing loss of function. The analysis in Naumovozyma castellii shows that the noncomplementing ohnolog is expressed at a lower level and has become nonessential. Taken together, our results indicate that HRR25 orthologs are undergoing gradual nonfunctionalization.
Playfulness and the meaningful life: an active inference perspective
Authors: Kiverstein Julian , Miller Mark 
Published: November 2023

Abstract
Our paper takes as its starting point the recent proposal, at the core of this special issue, to use the active inference framework (AIF) to computationally model what it is for a person to live a meaningful life. In broad brushstrokes, the AIF takes experiences of human flourishing to be the result of predictions and uncertainty estimations along many dimensions at multiple levels of neurobiological organization. Our aim in this paper is to explain how AIF models predict that uncertainty can sometimes, under the right conditions, be conducive to the experiences of flourishing. Our focus is on playfulness, because playful individuals have learned a high-level prior that in certain safe contexts, uncertainty and error should be tolerated and explored. They have expanded the phenotypic bound on the amount of surprise they are prepared to tolerate in their lives. The positive embracing of uncertainty has a number of positive knock-on effects for the kind of lives playful individuals are able to lead. First, a playful individual attends to the world in a way that is open and expansive, a mode of attending that is effortless and therefore conducive to being in the present. This openness to the present moment allows for deep engagement and participation in experience that can furnish a renewed appreciation for life. Second, playful individuals will actively seek out spaces at the edge of their own abilities and will therefore be more likely to grow and develop in their skills and relationships in ways that contribute to their living a good life. Finally, playful agents seek out situations in which they can monitor, observe, and learn from their own affective responses to uncertainty. Thus, uncertainty becomes something familiar to them that they not only learn to tolerate but also enjoy positively exploring, in ways that provide them opportunities to grow. For these three reasons, we will argue that playfulness and openness to experiences of uncertainty and the unknown may be important ingredients in human flourishing.
Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes
Authors: Xue Feng , Li Fei , Zhang Ke-ming , Ding Lufeng , Wang Yang , Zhao Xingtao , Xu Fang , Zhang Danke , Sun Mingzhai , Lau Pak-Ming , Zhu Qingyuan , Zhou Pengcheng , Bi Guo-Qiang 
Published: November 2023

ABSTRACT
To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the equipment. Here, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in mice. Proof-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.
Aitongping patch could alleviate cancer pain via suppressing microglia activation and modulating the miR-150-5p/CXCL12 signaling
Authors: Chen Yunlong , Wu Mianhua 
Published: November 2023

Abstract

Purpose
We aimed to investigate the pharmacological effects and mechanisms of the Aitongping formula for treating cancer pain.

Methods
We enrolled 60 cancer patients with Numeric Rating Scale above 4 and grouped them randomly as a Control group (N = 30) and a Patch group (N = 30). We also established bone cancer mice models via tumor implantation. And the animal groups were established as a Sham group, a tumor cell implantation (TCI) group, a TCI + Patch group, and a Patch group.

Results
After the validation of successful tumor implantation, we identified candidate miRNAs and genes that were dysregulated in TCI mice and compared their expressions between different mice groups. We also observed the effect of Aitongping patch in vitro in mice primary microglia. The time to disease progression and cancer stability were prolonged by Aitongping patch in cancer patients. And the daily morphine dose was lower, and patients’ quality of life was improved in the Patch group. Moreover, Aitongping patch alleviated cancer pain and inhibited microglia activation after the successful implantation of bone tumor in TCI mice. We also observed the dysregulation of miR-150-5p and chemokine CXC motif ligand 12 (CXCL12) mRNA in TCI mice. And CXCL12 was found to be targeted by miR-150-5p. Aitongping patch was found to upregulate miR-150-5p and downregulate CXCL12 in vivo and in vitro.

Conclusion
Aitongping patch could alleviate cancer pain via suppressing microglia activation, and the downregulation of miR-150-5p, as well as the upregulation of CXCL12 mRNA and protein, induced by tumor implantation or lipopolysaccharide stimulation, was restored by Aitongping treatment.
Effect of basal metabolic rate on rheumatoid arthritis: a Mendelian randomization study
Authors: Zhang Qin , Liu Ang , Huang Cheng , Xiong ZhenCheng , Cheng Qi , Zhang Jun , Lin Jun , Yang Huilin 
Published: November 2023

Abstract

Purpose
Basal metabolic rate (BMR) as one of the most basic and significant indicators of metabolism has been associated with human health. Previous studies showed that the development of rheumatoid arthritis (RA) is linked to BMR; however, the causal relationship between BMR and RA is unknown. Thus, we aimed to explore the causal relationship between BMR and RA as well as RA-related factors.

Methods
Mendelian randomization (MR) analysis was performed on collected genome-wide association studies information. The effect of horizontal pleiotropy was detected by MR-PRESSO and MR-Radial. Five MR analysis methods were applied, including inverse variance weighted, MR-Egger, weighted median, weighted mode, and simple mode. Four sensitivity analysis methods were used for the validation of the significant MR analysis results. A two-component mixture of regressions method was additionally used to validate single nucleotide polymorphisms and to verify results.

Results
Genetically, there is a causal effect of BMR on overall RA (odds ratio = 1.25, 95% confidence interval: 1.07–1.47, PIVW = .006), seropositive RA (odds ratio = 1.20, 95% confidence interval: 1.01–1.44, PIVW = .035), and seronegative RA (odds ratio = 1.36, 95% confidence interval: 1.04–1.78, PIVW = .023). Sensitivity analyses validated the robustness of the above associations. No evidence supported the effect of RA on BMR. Moreover, BMR showed no causal relationship with rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate, interleukin-1β, tumor necrosis factor-α, and matrix metallopeptidase 3.

Conclusion
MR results implied the causal effect of BMR on RA and raised our attention to the importance of BMR in RA’s pathology.
Roundtable: How do We Connect Public Administration and Human Rights?
Authors: Roberts Alasdair , Resh William , Basu Rumki , Onyango Gedion , Sullivan Helen , Peci Alketa , Kapucu Naim , Schomaker Rahel , Mele Valentina 
Published: November 2023

Abstract
Global recognition that there are universal human rights and that governments have a duty to respect them, was one of the most important developments of the 20th century. In this century, though, human rights are challenged in many places. What role do scholars and practitioners in public administration play in protecting human rights? This question has not received adequate attention in the field. In this roundtable, nine scholars explore the different ways in which public administration scholarship and practice may contribute to the advancement of fundamental human rights. A general theme is the need within our field for more systematic attention to the subject of human rights. Contributors identify topics that deserve particular attention, such as the protection of democracy, the provision of services essential to personal security and development, and the empowerment of Indigenous peoples.
Sleep inequities and associations between poor sleep and mental health for school-aged children: findings from the New Zealand Health Survey
Authors: Muller Diane , Signal T Leigh , Shanthakumar Mathangi , Paine Sarah-Jane 
Published: November 2023

Abstract
In Aotearoa/New Zealand, ethnic inequities in sleep health exist for young children and adults and are largely explained by inequities in socioeconomic deprivation. Poor sleep is related to poor mental health for these age groups but whether sleep inequities and associations with mental health exist for school-aged children is unclear. We aimed to (1) determine the prevalence of poor sleep health including sleep problems by ethnicity, (2) examine social determinants of health associated with poor sleep, and (3) investigate relationships between poor sleep and mental health for 5–14-year-olds using cross-sectional New Zealand Health Survey data (n = 8895). Analyses included weighted prevalence estimates and multivariable logistic regression. Short sleep was more prevalent for Indigenous Māori (17.6%), Pacific (24.5%), and Asian (18.4%) children, and snoring/noisy breathing during sleep was more prevalent for Māori (29.4%) and Pacific (28.0%) children, compared to European/Other (short sleep 10.2%, snoring/noisy breathing 17.6%). Ethnicity and neighborhood socioeconomic deprivation were independently associated with short sleep and snoring/noisy breathing during sleep. Short sleep was associated with increased odds of anxiety, attention deficit hyperactivity disorder, and activity-limiting emotional and psychological conditions after adjusting for ethnicity, deprivation, age, and gender. In addition, long sleep was independently associated with increased odds of depression. These findings demonstrate that for school-aged children ethnic inequities in sleep exist, socioeconomic deprivation is associated with poor sleep, and poor sleep is associated with poor mental health. Sociopolitical action is imperative to tackle social inequities to support sleep equity and mental health across the lifecourse.