bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infantile myofibromatosis: Small bumps pose big problems
Authors: Lee Hillary C , Amin Amee A , Chikwava Kudakwashe R , Smith Valeria R , Fernandes Caraciolo J 
Published: February 2025

Background Infantile myofibromatosis (IM) is a disorder characterized by proliferation of benign myofibroblastic tumors that typically manifest as solitary or multiple nodules in the skin, muscle, bone, subcutaneous tissues, and visceral organs and can pose significant morbidity and mortality risks, particularly in cases involving visceral organs or causing functional impairment. These soft tissue lesions are the most prevalent benign fibrous tumors that present before age two and can undergo spontaneous regression or are amenable to surgical resection. Case A preterm, male infant was born via Caesarean section to a mother with a trichorionic, triamniotic pregnancy following preterm labor. Within the first week of life, several well-circumscribed, smooth, non-tender, and soft nodules with some mobility were noticed along the border of the ribs, across the trunk, back, and lower extremities. Ultrasound imaging confirmed well-circumscribed hypoechoic, intramuscular nodules, and biopsy evaluation showed atypical spindle cell proliferation. The biopsied lesion was PDGFRB-mutated on molecular genetic studies, confirming a diagnosis of myofibromatosis. The infant developed mixed lytic and sclerotic deformities of a variety of bones, necessitating treatment given disease progression. Conclusion Successful clinical management with low-dose metronomic chemotherapy (methotrexate and vinblastine) is possible and can treat extensive disease, as seen in our patient.
Early postnatal weight changes in opioid-exposed infants managed using the Finnegan Neonatal Abstinence Scoring System Versus Eat, Sleep, Console
Authors: Dennison Emma , Coo Helen , Khurshid Faiza 
Published: February 2025

Background Despite the many clinical benefits of Eat, Sleep, Console (ESC) to manage infants with neonatal abstinence syndrome (NAS), a recent article theorized that ESC may place infants at an increased risk of excessive postnatal weight loss. The objective of this study was to compare weight changes in the early postnatal period among infants exposed to opioids in utero and managed using 1) the Finnegan Neonatal Abstinence Scoring System (FNASS) or 2) ESC. Methods Pre-post analysis of medical records for opioid-exposed infants born July 1, 2017-May 31, 2023. Type of feeding (exclusive breastfeeding, formula only, combination) and weight changes were compared between the FNASS (n = 45) and ESC (n = 25) groups. Results Type of feeding differed significantly between the groups during the first 5 days of life and at discharge: higher proportions of the FNASS group were exclusively breastfed and higher proportions of the ESC group received formula. There were no significant differences in daily weight changes over the first 5 days of life when we controlled for type of feeding. The average daily weight change during hospitalization did not differ significantly between the two groups (FNASS: median = −53.3 grams/day [IQR: −65.2, −40.8]; ESC: median = −45.9 [IQR: −57.8, −25.5]; p = 0.19). Conclusions We found no evidence of excessive weight loss in the early postnatal period among opioid-exposed infants managed using ESC as compared to FNASS. However, our findings suggest that breastfeeding should be more actively promoted and supported when centers transition from the FNASS model to ESC.
Effects of Supramaximal Intensity Interval Training on Resistin and Cardiometabolic Health Indices in Overweight Nonpostmenopausal Women
Authors: Mohammadnia Ahmadi Mohsen , Najarian Effat , Nezamdoost Zeynab , Sadeghi-Tabas Saber , Abtahi Eivary Seyed Hosein 
Published: February 2025

Background: Adipose tissue is an endocrine organ that produces various bioactive molecules known as adipokines, including resistin, which is be highly expressed in people with obesity and cardiovascular disease (CVD). The effects of supramaximal high intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on serum levels of resistin and various cardiometabolic health indices, were investigated. Hypothesis: Supramaximal and moderate interval training induce comparable effects on serum resistin levels and cardiometabolic health indices. Study Design: Cohort study. Methods: Thirty overweight adult women were assigned to 1 of 3 groups: HIIT (2 sets of 8 intervals, each with 30 seconds exercise at 100%-110% maximal aerobic speed [MAS] followed by 30 seconds rest at 50% MAS; for 6 weeks with 3 sessions per week), MIIT (2 sets of 8 intervals, each with 30 seconds exercise at 70%-80% MAS followed by 30 seconds rest at 50% MAS; for 6 weeks with 3 sessions per week), or a control group. Results: Triglyceride levels were significantly higher in the control group compared with both the HIIT and MIIT groups ( P = .02 and .01, respectively). High-density lipoprotein levels were also elevated significantly in the experimental groups compared with the control group ( P = .04 and .03, respectively). Serum resistin increased significantly from pretest levels in the control group ( P < .01). Between-group comparisons showed that resistin levels were significantly higher in the control group than in the experimental groups ( P < .01 and .01, respectively). Conclusion: Six weeks of HIIT can reduce resistin levels and improve cardiometabolic health indicators in nonpostmenopausal women. Although 6 weeks of MIIT does not reduce resistin, it does decrease systolic blood pressure and obesity-related factors in nonmenopausal women. Clinical Relevance: Supramaximal interval training may be recommended to control bioactive molecules produced from adipose tissue that are linked to CVD.
Relationships Among PTSD, Trait Mindfulness, and Factors of SUD in Veterans Enrolled in Specialty SUD Treatment
Authors: Rehder Kristoffer , Morasco Benjamin J. , Bowen Sarah 
Published: February 2025

Objective: A growing body of evidence points to a role for mindfulness in the development or maintenance of co-occurring posttraumatic stress disorder (PTSD) and substance use disorder (SUD). However, the mechanisms of this relationship remain unclear in the veteran population. This study seeks to understand how PTSD and facets of mindfulness are associated with factors of SUD in veterans enrolled in a VA specialty SUD treatment program. Method: Veterans enrolled in the SUD treatment program were recruited from group classes and waiting rooms, and completed measures assessing SUD-related factors of frequency of alcohol use, hazardous alcohol use, consequences from substance use, and craving, as well as PTSD symptoms, mindfulness facets, and depressive symptoms. Three hierarchical multiple regressions assessed the extent to which significant relationships between mindfulness and SUD-related factors exist beyond associations commonly found with PTSD, depression, and craving. Results: Participants (n = 159) were predominately male (91.2%) and White (86.2%) (age: Mean = 57.3; SD = 12.9). After controlling for demographic factors, PTSD, and clinical variables, mindfulness facets were associated with SUD-related factors; observe was positively related to frequency of alcohol use, non-judging was positively related to hazardous alcohol use, and non-reactivity was negatively associated with consequences from use. Exploratory analyses suggested that non-reactivity mediated the relationship between PTSD and consequences from use. Conclusions: Facets of observe, non-judging, and non-reactivity may help explain relationships between PTSD and SUD-related factors. However, associations with non-judging and observe were in the opposite direction hypothesized. More research is needed to understand positive associations between mindfulness and factors of SUD in veteran samples.
Effects of polypropylene glycol-treated montmorillonite/carbon black as a filler with rubber compound properties
Authors: Asghari Barzegar Zohreh , Malekzadeh Mercedeh 
Published: February 2025

Abstract
Carbon black is commonly used as a filler in the rubber industry. However, it can cause serious damage to human health and to ecosystems. Today, reducing the use of this substance via alternative materials is receiving increased attention. Clay minerals such as montmorillonite can be substituted for carbon black as environmentally friendly fillers for rubber compounds. The uniform dispersion of montmorillonite and its compatibility with the rubber matrix are the main principles for using this material in the rubber industry. To this end, montmorillonite was surface treated with various dosages (1.0, 1.5 and 2.0 wt.%) of polypropylene glycol. The surface-treated montmorillonites were investigated using attenuated total reflection Fourier-transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and X-ray diffraction analysis. The results indicated that the treatment expanded the interlayer spaces of the montmorillonite and improved surface hydrophobicity. The untreated and treated montmorillonites were used with carbon black as dual fillers in natural rubber/styrene butadiene-based compounds. The cure characteristics, thermal stability, some mechanical properties and dispersion states were evaluated. The curing study indicated a faster optimum cure time, scorch time and increased torque difference for the rubber compounds filled with surface-treated montmorillonites. Thermal analysis of the rubber compounds illustrated that the interval between the initial and final temperature of decomposition could be increased via the treatment. Surface-treated montmorillonite samples, especially the sample containing 1 wt.% polypropylene glycol, showed improved abrasion resistance, resilience and compression set values.
The effect of storage time and temperature on the proteomic analysis of FFPE tissue sections
Authors: Koh Jennifer M. S. , Sykes Erin K. , Rukhaya Jyoti , Anees Asim , Zhong Qing , Jackson Christopher , Panizza Benedict J. , Reddel Roger R. , Balleine Rosemary L. , Hains Peter G. , Robinson Phillip J. 
Published: February 2025

Abstract
Formalin-fixed paraffin-embedded (FFPE) tissues present an important resource for cancer proteomics. They are more readily available than fresh frozen (FF) tissues and can be stored at ambient temperature for decades. FFPE blocks are largely stable for long-term preservation of tumour histology, but the antigenicity of some proteins in FFPE sections degrades over time resulting in deteriorating performance of immunohistochemistry (IHC). It is not known whether FFPE sections that have previously been cut from blocks and used for liquid chromatography-mass spectrometry (LC–MS) analysis at a later time are affected by storage time or temperature. We determined the stability of FFPE sections stored at room temperature (RT) versus − 80 °C over 48 weeks. The stored sections were processed at different timepoints (n = 11) and compared to sections that were freshly cut from FFPE blocks at each timepoint (controls). A total of 297 sections (rat brain, kidney and liver stored at RT, − 80 °C or freshly cut) were tryptically digested and analysed on TripleTOF 6600 mass spectrometers in data-dependent acquisition (DDA) mode. Kidney and liver digests were also analysed in data-independent acquisition (DIA) mode. The number of proteins and peptides identified by DDA with ProteinPilot and some common post-translational modifications (PTMs) were unaffected by the storage time or temperature. Nine of the most common FFPE-associated modifications were quantified using DIA data and all were unaffected by storage time or temperature. Therefore, FFPE tissue sections are suitable for proteomic studies for at least 48 weeks from the time of sectioning.
Bridging the gap: access to health care and control of type 2 diabetes mellitus, hypertension and bronchial asthma among Egyptian women
Authors: Elmeshmeshy Eman Ibrahim , Abdelaziz Basma , Soliman Saeed 
Published: February 2025

Abstract

Background
Non-communicable diseases burden is rising globally; women are disproportionately affected by both non-communicable diseases burden and lack of access to health care. Research on the relationship between access to health care and non-communicable diseases control are limited. We aimed to assess the relationship between women’s access to health care and three non-communicable diseases control.

Methods
A cross-sectional study was conducted on 420 women diagnosed with diabetes mellitus, hypertension and/or Asthma. Access to health care was assessed through pretested validated Arabic version of access 31 questionnaire. The control status of diabetes mellitus, hypertension, and asthma was assessed according to the American Diabetes Association HbA1c targets, World Health Organization Guidelines, and the Global Initiative for Asthma control assessment tool, respectively. The associations were assessed using univariate and multivariate logistic regression analysis.

Results
(83%) of the participants had poor access to health care, of those, (39.0%) achieved non-communicable diseases control, while (16.9%) participants had good access to health care, of them, (83.1%) had their non-communicable diseases controlled. This difference in non-communicable diseases control proportions across access to care groups was statistically significant (P < 0.001). Women with good access to health care had higher odds (Adjusted Odds Ratio 6.33, 95% confidence interval: 3.24–12.55) of having their non-communicable diseases controlled compared with those with poor access.

Conclusion
Improving access to health care is essential for achieving better non-communicable diseases control.
Perceptions of ethical decision-making climate among clinicians working in European and US ICUs: differences between religious and non-religious healthcare professionals
Authors: Jensen Hanne Irene , Bülow Hans-Henrik , Dierickx Lucas , Vansteelandt Stijn , Vaschetto Rosanna , Élö Gábor , Piers Ruth , Benoit Dominique D. 
Published: February 2025

Abstract

Background
Making appropriate end-of-life decisions in the intensive care unit (ICU) requires shared interprofessional decision-making. Thus, a decision-making climate that values the contributions of all team members, addresses diverse opinions and seeks consensus among team members is necessary. Little is known about religion’s influence on ethical decision-making climates. Therefore, this study aimed to examine the association between religious belief and ethical decision-making climates.

Methods
The study was a cross-sectional analytical observation study as a part of the prospective observational DISPROPRICUS study. A total of 2,275 nurses and 717 physicians from 68 ICUs representing 12 countries in Europe and the US participated. All participants were asked which religion (if any) they belonged to and how important their religion (if any) was for their professional attitude towards end-of-life care. Perceptions of ethical decision-making climates were evaluated using a validated, 35-item self-assessment questionnaire that evaluates seven factors. Using cluster analysis, ICUs were categorised into four ethical decision-making climates: good, average (with nurses’ involvement at the end of life), average (without nurses’ involvement at the end of life) and poor.

Results
Of the 2,992 participants, 453 (15%) were religious (had religious convictions and found them important or very important for their attitude towards end-of-life care). The remaining 2,539 were non-religious (i.e. had religious convictions but assessed that they were not important for their attitude towards end-of-life care). When adjusting for country and ICU, the overall perception of the four ethical climates was associated with religious beliefs, with non-religious healthcare providers having more positive perceptions of the ethical climates compared to religious healthcare providers (p < 0.01). Within good climates, non-religious healthcare providers rated leadership by physicians (p < 0.01), interdisciplinary reflection (p = 0.049) and active decision-making by physicians (p = 0.02) as more positive compared to religious participants. In poor climates, religious healthcare providers had a more positive perception of the active involvement of nurses (p = 0.01). Within the other climates, no differences were found.

Conclusions
Overall perceptions of ethical decision-making climates were associated with religious beliefs, with non-religious healthcare providers generally having a more positive perception of the ethical climates than religious healthcare providers.
A qualitative analysis of unintended effects of a digital conditional cash transfer intervention to encourage healthcare utilization in Southern Madagascar
Authors: Franke Mara Anna , Neumann Anne , Nordmann Kim , Suleymanova Daniela , Ravololohanitra Onja Gabrielle , Knauss Samuel , Emmrich Julius Valentin 
Published: February 2025

Abstract

Introduction
Cash transfer interventions, including those using mobile money, are becoming increasingly widespread, particularly in Sub-Saharan Africa. As such interventions can have significant positive and negative unintended consequences, further analyses are needed to identify these consequences.

Methods
We investigated the unintended consequences of a digital conditional cash transfer intervention implemented at fifteen health facilities in Southern Madagascar. The intervention offered partial cost coverage for patients seeking care for potentially life-threatening conditions, accidents and injuries, maternal or pediatric care between February 2021 and June 2022. We conducted a qualitative analysis of in-depth interviews with policymakers, healthcare providers, (non-) beneficiaries of the intervention, and staff that implemented the intervention using reflexive thematic analysis.

Results
We identified three key positive and three key negative unintended consequences of the intervention. The key positive unintended consequences were: i) improved quality of care, ii) improved interpersonal relationships, including between patients and providers and between healthcare providers, and iii) digital skills development of healthcare providers and increased trust in mobile money. The three key negative consequences we identified were i) facility overcrowding, ii) an increase in costs of care, and iii) cases of hospital imprisonment.

Conclusions
Designers and implementers of future (digital) cash transfer interventions should carefully consider and proactively seek to leverage the positive and mitigate the negative unintended consequences of cash transfer interventions for healthcare such as those highlighted in our work.
Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus)
Authors: Bazina Walaa K. , Tawfik Wesam A. , Abd Elghany Nadia A. , Saadony Saadea , Abdul Kari Zulhisyam , Alamoudi Muna Omer , Aly Mohamed Y. M. , Younis Abuelhassan Elshazly , Mathew Roshmon Thomas , Eissa Moaheda E. H. , Munir Mohammad Bodrul , Ibrahim Saadiah , Yousef Ismail , Omar Yusuf O. H. , Eissa El-Sayed Hemdan , Abd Elnabi Heba E. 
Published: February 2025

Abstract

Background
This study aimed to evaluate the effects of selenium nanoparticles (SeNPs) and/or vitamin E (VE) on the growth, body composition, metabolic parameters, histopathology, and resistance of Nile tilapia to Aspergillus flavus.

Results
Monosex Nile tilapia fingerlings were sourced from the Bazina farm and hatchery in Ismailia Governorate, Egypt, where the experiment was also conducted. The fish were acclimatized for 15 days before the trial. A total of 240 fingerlings (average weight 46 ± 3.0 g/fish) were divided equally across 12 concrete tanks (1 × 1 × 1.2 m, 1 m³ capacity), with 20 fish per tank. The fish were fed a control diet (T0), which was a basal diet with no supplementation, or one of three experimental diets for 60 days: T1 (1 mg SeNPs/kg), T2 (100 mg VE/kg), and T3 (1 mg SeNPs + 100 mg VE/kg). The experiment followed a completely randomized design (CRD) with three replicates per treatment. The combination of SeNPs and VE (T3) resulted in the best feed conversion ratio. A slight but significant increase (P < 0.05) in whole-body composition was observed in all treatment groups compared to the control. Biochemical parameters, serum digestive enzyme activity, and antioxidant levels improved significantly with dietary supplementation. Histopathological analysis revealed somewhat lacerated gill arches in fish fed SeNPs, VE, or their combination, but the overall gill structure remained normal. The SeNPs + VE group exhibited improved villi length and normal morphology of portal veins and hepatic sinusoids, though some vacuolated hepatocytes were noted. Fish in the SeNPs + VE group had the lowest mortality rates and the highest resistance to A. flavus.

Conclusion
Supplementing diets with SeNPs and/or VE enhances growth, body composition, biochemical parameters, and histopathology in Nile tilapia. The combination of 1 mg SeNPs + 100 mg VE/kg improves immune response and growth, offering a promising strategy to enhance Tilapia health and productivity.
Effects of increasing levels of rubber seed cake on growth performance, nutrient digestion metabolism, serum biochemical parameters, and rumen microbiota of Hu sheep
Authors: Zhao Huwei , Hua Jinling , Lu Wenwen , Yan Longfei , Zhang Min , Chen Chao , Lv Xiaokang 
Published: February 2025

Abstract
This study aimed to reveal the effects of increasing levels of rubber seed cake (RSC) on growth performance, nutrient digestion metabolism, serum biochemical parameters, and rumen microbiota in Hu sheep. In this study, 48 Hu sheep, weighing 17.01 ± 0.57 kg at 3 months of age, were randomly divided into four treatments: 0% rubber seed cake (RSC0%), 6% rubber seed cake (RSC6%), 12% rubber seed cake (RSC12%) and 18% rubber seed cake (RSC18%), with 12 sheep per group. Compared to the RSC0%, the ADG and DMI of the RSC6% and RSC12% were increased (P > 0.05). The apparent digestibility of OM and EE quadratically (P < 0.05) changed with the increase of RSC supplementation, with the greatest apparent digestibility of OM and EE observed in the RSC6% diet. With increased RSC supplementation, the N intake and fecal N increased linearly (P < 0.05), and the apparent digestibility of N reduced linearly (P < 0.05). As the increase of RSC supplementation, the serum levels of IgA, IgM, IgG, IL-4, T-AOC, and GSH-Px increased linearly (P < 0.05), and the serum level of IL-6 reduced linearly (P < 0.05). The serum level of IL-1β reduced quadratically (P < 0.05) with the increased RSC dose, and the serum level of SOD increased quadratically (P < 0.05) with the increased RSC dose. The ruminal NH3-N and the relative abundance of norank_Muribaculaceae quadratically (P < 0.05) changed with increased RSC supplementation, and the greatest relative abundance of norank_Muribaculaceae was observed in the RSC6% diet. In general, incorporating RSC into the diet of Hu sheep did not adversely affect growth performance and rumen fermentation characteristics. Supplementing with 6% RSC enhanced the relative abundance of norank_Muribaculacea in the rumen fluid and the immune and antioxidant capabilities. However, supplementing with 12 and 18% RSC might have negatively impacted nutrient digestion and metabolism. Therefore, this study recommended replacing corn and soybean meal with 6% RSC in the diet of Hu sheep.