bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective effects of Vitamin E against Zinc Oxide nanoparticles-induced histotoxicity of liver and testicular tissue, genotoxicity and biomarker stress in male albino rats
Authors: Hosney Amel , Khamis Hussein , Ali Hamasa , Kheirallah Nessrin 
Published: January 2024

Abstract
Nano zinc oxide has the potency to be harmful, so it is important to assess its effects on the human health and biological system. In the current study, vitamin E (100 mg/kg) was used to explore its antioxidant role in mitigating the potential toxicity of ZnO NPs (50 and 200 mg/kg) in male albino rats tissues. Sixty adult male albino rats weighing 180–200 g were arbitrarily divided into six groups: G1:control group,G2: vita E (100 mg/kgb.w) group, G3: Zn NPs (50 mg/kg b.w) group, G4: Zn NPs (200 mg/kg b.w), G5: vita E + Zn NPs(50 mg/kg b.w) group and G6:Vita E + Zn NPs (200 mg/kg b.w) group. Giving both Vita and ZnNPs daily by oral gavage for 4 weeks. The results revealed that exposure to the structure of the liver and testicular tissues was examined by light microscopy, DNA damage by the comet assay, metallothionein levels and sex hormones evaluation by ELISA, and several stress markers by spectrophotometric methods. Sperm count and motility were assessed by optical microscopy. Detailed analysis of the liver and testicular tissue of rats treated with 50 and 200 mg/kg ZnO NPs revealed many adverse effects of nanoscale particles in tissues structure, accompanied by focal necrosis, inflammatory cellular infiltration in liver tissues and distorted seminiferous tubules with disorganized germ cells in tests tissues, increased lipid peroxidation, DNA damage, and reduced levels of antioxidant enzymes. Due to their tiny size that allow them to penetrate physiological barriers, ZnO NPs can enter, translocate within, and damage living organisms. Nevertheless, co-administration of ZnO NPs with Vita E significantly (p < 0.05) reversed the biochemical alterations associated with ZnO NPs administration and lead to improvement of the histopathological picture of hepatic and testicular tissues. Findings related to Vita E may either inhibit the activity of (ROS) molecules and prevent their binding to the DNA structure and /or scavenging peroxyl lipid radicals inducing DNA-damaging products. So, the present results indicated that Vita E effectively attenuates the adverse effects of ZnO NPs and could mitigate or prevent its toxicity which lead finally to healthy tissues of liver and testes.
New star identification algorithm based on Hausdorff distance for the initial attitude establishment mode in star sensor
Authors: Zahednamazi Mona , Toloei Alireza 
Published: January 2024

Abstract
One of the best attitude sensors for space applications is the star sensor. This sensor uses the stars in the field of view for attitude determination. The star sensor can determine the attitude with and without knowledge of the previous attitude. Determining the attitude without knowledge of the previous attitude in the star sensor is called the initial attitude establishment mode. The star identification algorithms of this mode are called the lost-in-space algorithms. Because in this mode, all the stars of the celestial sphere must be searched. This paper presents a new lost-in-space algorithm based on Hausdorff distance. Two different approaches have been proposed for identification. The first approach is designed based on the pivot star, and the second approach uses the segmentation of the celestial sphere. To increase the identification rate, another step based on a specific angle also has been examined. This step does not require a database. To select neighboring stars in these methods, three approaches have been proposed, one approach is based on star magnitude, and the two other approaches are based on two cost functions. The results show that the approach of using the pivot star along with the angle and selecting the neighboring stars based on the magnitude has a better performance and its identification rate is 99% for stars brighter than 6 \({\text{M}}_{\text{v}}\). Also, comparing the identification time of the Hausdorff algorithm with the pyramid algorithm, in the case of a linear search of the database, shows that the average identification time for stars brighter than 6 \({\text{M}}_{\text{v}}\) is 13.75 times less than the pyramid algorithm.
Ecological factors associated with parasite Ichthyophthirius multifiliis gene abundance in the aquatic environment：novel clues for ecological control of Ichthyophthiriasis
Authors: Hu Guang-Ran , Wang Run-Qiu , Huang Ke , Bu Xia-Lian , Zhao Wei-Shan , Zou Hong , Li Wen-Xiang , Wu Shan-Gong , Li Ming , Wang Gui-Tang 
Published: January 2024

Abstract
Background
Ichthyophthirius multifiliis is considered one of the most harmful parasite, which can invade various economic freshwater fish. It can cause great economic losses to the aquaculture and ornamental fish industries. Until today, there is no efficient drug or vaccine to control this disease. The classic triangle disease model suggests that the occurrence of a disease is the result of interactions between the host, environment and pathogen. Here we aim to explore the relationship between the environmental I. multifiliis’s genes abundance and ecological factors.
Results
Based on shotgun metagenomics sequencing technology, the relationship between biotic factors and I. multifiliis’s genes abundance was analyzed. We found that there has a significant negative correlation between Bacteria genes abundance and I. multifiliis’s genes abundance, a significant positive correlation between Archaea genes abundance and I. multifiliis’s genes abundance. When exploring the effects of physicochemical factors on the plankton community and I. multifiliis’s genes abundance between different health condition groups, it was found that nitrate was the most correlated factor with differences in the plankton community between groups; In ponds outbroken Ichthyophthiriasis, nitrate concentrations were significantly negatively correlated with I. multifiliis’s genes abundance. In the analysis of nitrogen cycle related functional genes, the abundance of both nitrogen cycle related and nitrate metabolism related functional genes were found to be higher in the ponds without outbreaks of Ichthyophthiriasis. Finally, significant different plankton (genus level) between groups were also analyzed, as well as the contribution of species associated with nitrate metabolism.
Conclusions
Our study identified microbiological and physicochemical factors that maybe associated with Ichthyophthiriasis. This survey can provide clues for future efficient ecological control of Ichthyophthiriasis.
Spinal muscular atrophy genetic epidemiology and the case for premarital genomic screening in Arab populations
Authors: Tayoun Ahmad Abou , Rabea Fatma , Naofal Maha El , Chekroun Ikram , Khalaf Mona , AlZaabi Nuha , ElHalik Mahmoud , Dash Swarup , Saba Yaser El , Ali Azhari , Abraham Smitha , Fathi Khansa , Shekhy Jwan , Aswad Saad , Elbashir Haitham , Alkuraya Fowzan , Loney Tom , Alsheikh-Ali Alawi , Khayat Abdulla Al 
Published: January 2024

Abstract

Background
Spinal muscular atrophy (SMA) is a fatal autosomal recessive disorder for which several treatment options, including gene therapy, have become available. SMA incidence has not been well-characterized in most Arab countries where rates of consanguinity are high. Understanding SMA disease epidemiology has significant implications for screening, prevention, and treatment in those populations.
Methods
We preformed SMA diagnostic testing in a clinical multi-national patient cohort (N = 171) referred for hypotonia and/or muscle weakness. In addition, we carried out genetic newborn screening for SMA on 1,252 healthy Emirati newborns to estimate the carrier frequency and incidence of the disease in the United Arab Emirates.
Results
Patients referred for SMA genetic testing were mostly Arabs (82%) representing 18 countries. The overall diagnostic yield was 33.9%, which was higher (> 50%) for certain nationalities. Most patients (71%) had two SMN2 copies and earlier disease onset. For the first time, we estimate SMA carrier frequency (1.5%) and incidence of the disease (1 in 5,990 live births) in the United Arab Emirates. Using birth and marriage rates in two Arab populations (United Arab Emirates and Saudi Arabia), as well as disease incidence in both countries, we show that, besides preventing new cases, premarital genetic screening could potentially lead to $10 to $324 million, respectively, annual cost savings relative to postnatal treatment.
Conclusion
The SMA carrier frequency and incidence we document suggests high potential benefit for universal implementation of premarital genomic screening for a wide range of recessive disorders in Arab populations.
EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells
Authors: Li Yuxi , Chang Hsun-Ming , Zhu Hua , Sun Ying-Pu , Leung Peter C. K. 
Published: January 2024

Abstract

The epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in regulating the ovulatory process. Pentraxin 3 (PTX3), an essential ovulatory protein, is necessary for maintaining extracellular matrix (ECM) stability during cumulus expansion. The aim of this study was to investigate the impact of EGF-like factors, AREG, BTC, and EREG on the expression and production of PTX3 in human granulosa-lutein (hGL) cells and the molecular mechanisms involved. Our results demonstrated that AREG, BTC, and EREG could regulate follicular function by upregulating the expression and increasing the production of PTX3 in both primary and immortalized hGL cells. The upregulation of PTX3 expression was primarily facilitated by the activation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling pathway, induced by these EGF-like factors. In addition, we found that the upregulation of PTX3 expression triggered by the EGF-like factors was completely reversed by either pretreatment with the epidermal growth factor receptor (EGFR) inhibitor, AG1478, or knockdown of EGFR, suggesting that EGFR is crucial for activating the ERK1/2 signaling pathway in hGL cells. Overall, our findings indicate that AREG, BTC, and EREG may modulate human cumulus expansion during the periovulatory stage through the upregulation of PTX3.
Analysis, circuit design, and synchronization of a new 8D memristor-based chaotic system with application to chaotic masking and signal decoding
Authors: Kopp Michael 
Published: January 2024

Abstract
The most pressing modern problem of using chaotic systems in practice is the development of information encryption methods. To solve these problems, there is a need to develop multidimensional chaos generators. The article outlines the development of an 8D nonlinear dynamic system utilizing a memristor. An examination of innovative 8D dynamic systems was conducted, focusing on the determination of Lyapunov exponents, the construction of bifurcation diagrams, and the identification of equilibrium points. As a result of computer modeling of an 8D hyperchaotic system in Matlab-Simulink and LabVIEW, phase portraits of numerous strange attractors were obtained. Finally, using Multisim software, electronic circuits for new 8D chaos generators were built, which demonstrated similar behavior as in the Matlab-Simulink and LabVIEW models. The synchronization challenge for both identical 8D hyperchaotic systems was investigated using a nonlinear active control method. A simple approach to chaotic masking and decoding of signals based on an 8D memristive system is demonstrated.
Attitudes of Autistic Adults toward Genetic Testing for Autism
Authors: Gallion Tielle , Williams Zachary J , Niarchou Maria , Duncan Laura , Hooker Gillian , Taylor Kelly A 
Published: January 2024

Abstract
Genetic testing for autism has been a controversial topic within the autistic community. Opinions regarding benefits, risks, and limitations of genetic testing often differ between autistic people, researchers, and healthcare providers. The present study sought to understand the beliefs, attitudes, and intentions to pursue genetic testing of autistic adults, and compare perspectives of autistic people who have had genetic testing with those who have not. An international sample of 173 autistic adults (19 [11%] who had previously undergone autism-related genetic testing) completed an online survey with questions assessing beliefs, attitudes, and intentions to pursue genetic testing. Although beliefs and attitudes about genetic testing varied widely across the sample, the “typical” viewpoint was generally moderate (i.e., not strongly in favor of or against genetic testing). Autistic individuals who had received prior genetic testing had much more positive beliefs about autism-related genetic testing (d = 0.87, CI95% [0.37, 1.36]) and attitudes toward genetics (d = 1.10, CI95% [0.61, 1.58]) compared to those who had not received such testing, although there were no meaningful differences between those same groups regarding beliefs about genetic testing unrelated to autism (d = 0.02, CI95% [-0.45, 0.49], p = .93). Intention to genetically test oneself or one’s (hypothetical) children was also significantly predicted by autism-specific beliefs, attitudes, and prior genetic testing status. A large majority of the sample (78.6%) also agreed that autistic individuals would benefit from contact with a genetic counselor in certain situations. These findings suggest that the autistic community does not have a singular view of genetic testing, and for those autistic individuals who are interested in pursuing genetic testing for themselves or a family member, genetic counselors have the potential to play a key role in clinical care.
Venous thromboembolism and ovarian cancer risk: a Mendelian randomized study
Authors: liu xiaolin , Wang Shan , Lv Hongwei , Chen Enli , Yu Jing 
Published: January 2024

Abstract
Observational studies have reported an association between venous thromboembolism (VTE) and ovarian cancer risk (OC), but the evidence is not consistent. In this study, we will investigate the relationship between VTE and OC risk from a genetic perspective. Objective: This study explored the causal relationship between VTE and OC risk. Methods : The single nucleotide polymorphism ( SNP ) data associated with VTE and OC were obtained from the Finn and UK Biobank databases, respectively. All the pooled data based on genome-wide association studies ( GWAS ) were subjected to secondary data analysis, and the genetic loci closely associated with venous thromboembolism were selected as the instrumental variables, and were used as the instrumental variables by Mendelian randomised Egger regression, median weighting, IVW random-effects model, IVW random-effects model, and IVW random-effects model, respectively., IVW random-effects model, IVW radial method, IVW fixed-effects model five methods omodel are five evaluate the causal relationship between venous thromboembolism and ovarian cancer risk by OR value. METHODS: VTE patients (n = 9,176) and OC patients (n = 1,218) who met the same ethnicity and came from different regions were selected. Five methods, namely, Mendelian randomised Egger regression, median weighted method, IVW random effects model, IVW radial method, and IVW fixed effects model, were used to evaluate the causality between VTE and OC risk by OR, respectively. Sensitivity analyses were performed using Cochran's Q test, MR ⁃Egger regression intercept term, MR ⁃PRESSO, and leave-one-out method to assess the stability and reliability of the results. RESULTS: The GWAS for VTE and OC were screened for European ethnicity. In the MR analysis, we found that genetically predicted VTE was associated with an increased risk of OC. The results of Weighted median, Simple mode, Weighted mode, and MR Egger all showed similar trends (OR = 1.0006, 95% CI: 1.00007–1.0013). There was no heterogeneity of results ( P = 0.18) and no horizontal pleiotropy (P = 0.77). The instrumental variables selected for venous thromboembolism were all strong instrumental variables ( F = 669.7). The sensitivity analyses remained consistent, indicating that VTE was associated with a high prevalence of OC. CONCLUSION: The results of this study suggest that patients with VTE are at an increased risk of OC.
Using exploration and exploitation techniques to improve ranking models through (1+1)-Evolutionary Algorithms
Authors: Ibrahim Osman Ali Sadek 
Published: January 2024

Abstract
Exploration and exploitation are fundamental concepts within the domain of Nature-Inspired Algorithms (NIAs) when optimizing solutions. Exploration aims to traverse a substantial portion of the solution space, whereas exploitation is directed at refining the current solution toward either local or global optima. For example, mutation represents an exploration technique, while crossover and enhanced initialization strategies are employed for exploitation. In this research, four probability distributions are employed for mutation within NIAs, and ranking models derived from Dependent Click and Linear Regression (LR) are leveraged to enhance the exploitation process. Empirical findings indicate a preference for employing Gaussian Random Number (GRN) in conjunction with LR and Dependent Click initialization when evolving on the training dataset. Conversely, Levy Random Number generation in combination with LR demonstrates superior performance on the unseen test dataset, with GRN emerging as a strong contender. Furthermore, the integration of Simulated Annealing with the (1+1)-Evolutionary Strategy outperforms alternative methods in predictive ranking and evolutionary processes, both on the training and testing datasets, regardless of whether Linear ranking initialization is employed, in contrast to the novel (1+1)-Evolutionary Gradient Strategy and other (1+1)-Evolutionary Strategy variants. This paper presents experimental results conducted on the MQ2008 dataset and provides accompanying code packages.
A comparative analysis of biometric parameters of optic nerves obtained by ultrasonic sensors of varied frequencies
Authors: Neroev V. V. , Kiseleva T. N. , Zaytsev M. S. , Baeva A. V. , Eliseeva E. K. , Ushakov A. I. 
Published: January 2024

Purpose: a comparative analysis of biometric parameters of the optic nerve obtained by different diagnostic ultrasound sensors.Material and methods. We examined 20 healthy volunteers with emmetropia aged 20 to 40 years (40 eyes), average age 30.5 ± 5.4 years, who had no complaints or ophthalmic pathologies. Ultrasound scanning was performed on a multifunctional Voluson E8 (GE) scanner (11–18 MHz linear sensor), ophthalmic ultrasound device Ellex Eyecubed (a conventional 10 MHz transducer) and an ophthalmic scanner Absolu «Quantel Medical» (a 20 MHz transducer). All examinations were carried out by one operator who used the same scanning technique and measured the optic nerve sheath diameter (ONSD) and optic nerve diameter (OND) without sheaths in both eyes. Six consequent measurements of the ONSD and the OND parameters were performed to ascertain the reproducibility of the examinations and evaluate the variation coefficient.Results. The analysis revealed no statistically significant differences in the ONSD and in the OND obtained with 11–18 MHz, 10 MHz and 20 MHz transducers in the B-mode (р > 0.05). The minimum variation coefficient of the optic nerve thickness parameters was registered using a high-frequency 20 MHz transducer on the ophthalmic scanner. The biometry obtained with a high frequency 20 MHz transducer could be considered as the most reproducible.Conclusion. A high frequency 20 MHz transducer can be recommended for optimal visualization and precise evaluation of biometric parameters of the retrobulbar part of the optic nerve. Transducers of multifunctional scanners with the frequency range from 11 to 20 MHz can be used for measurements of the optic nerve sheath diameter.
Silicon-dried corneal graft crosslinking as a means to increase the effectiveness of urgent keratoplasty
Authors: Flora S. V. , Chentsova E. V. , Tselaya T. V. 
Published: January 2024

Purpose: to evaluate the effectiveness of silicon-dried cornea, previously subjected to corneal collagen UVA crosslinking, for urgent keratoplasty.Material and methods. 28 patients (16 males, 12 females), diagnosed with perforating corneal ulcer of various etiologies, underwent penetrating keratoplasty for eye-preserving purposes. 14 patients (the main group) underwent transplantation of a silicon-dried cornea, previously subjected to corneal collagen crosslinking according to the standard (Dresden) protocol while the remaining 14 patients (comparison group) underwent penetrating keratoplasty with not pre-treated silicon-dried cornea. In the postoperative period, we measured the time of primary complete epithelization of the graft and assessed the presence/absence of ulcers and erosions of the corneal graft 1, 3, 6 and 12 months after the discharge from the hospital. For this purpose, all patients underwent corneal biomicroscopy with corneal surface preliminary stained with a 1% sodium fluorescein solution.Results. Complete epithelization in both the main group and the comparison group was found to take place, on average, at the same time after surgery. However, over the entire observation period, the main group showed fewer relapses of ulcers and corneal graft erosions than the comparison group.Conclusion. The use of silicon-dried cornea, subjected to corneal collagen cross-linking, increases the effectiveness of perforated corneal ulcer treatment in emergency surgical care.
Efektivitas Media Bingo Untuk Pembelajaran Kosakata Bahasa Jepang Pada Siswa SMA
Authors: Yuvenza Figa Defri , Wikarya Rahmi Oktayory 
Published: January 2024

Based on researchers' observations, the study is in the background because students often find it difficult to memorize a Japanese vocabulary. The purpose of this study is to know the effectiveness of bingo media for the study of the Japanese vocabulary in high school students. The type of research used in this study is a quantitative study with a pre-design research design. The research design used was one group pretest posttest. The sample in this study is sophomores 1 as many as 20 students. Sampling retrieval in this study uses an impressive sampling technique. The data in this study is the result of pretest and posttest. The instrument used to collect data on an objective test of multiple choice as much as 30 grains of matter. Based on the calibrated test results can be seen from the value of sig (2-tailed) 0,000 < 0.05. H1 is accepted and h0 is denied, which leads to the conclusion that media bingo is significantly effective for the studies of the Japanese vocabulary of sophoma-grade science 1 high school pgri 1 padang. In addition, students have improved their study of Japanese vocabulary after using media bingo. This increase can be seen from an average of 58 pretests and posttests to 86.