bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary renal peripheral T‐cell lymphoma, not otherwise specified, treated with partial nephrectomy
Authors: Miki Airi , Tani Masaru , Tsutsui Kenji , Wakita Teppei , Horibe Yuki , Kakuta Yoichi , Tsutahara Koichi , Ishiko Jun , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Takao Tetsuya 
Published: October 2023

IntroductionRenal involvement by non‐Hodgkin's lymphoma is very rare, and the kidney as the primary site of this lymphoma is much more uncommon. We report a case of primary renal peripheral T‐cell lymphoma, not otherwise specified, treated with partial nephrectomy.Case presentationA 63‐year‐old man was hospitalized with coronavirus infectious disease, emerged in 2019 in the emergency department. Computed tomography examination showed a 2‐cm renal mass in the right kidney. Abdominal enhanced computed tomography examination revealed that the noted mass showed good enhancement in the corticomedullary phase and washout in the nephrogenic phase. No metastatic lesions were found. He was diagnosed as having cT1aN0M0 renal cell carcinoma, and robotic‐assisted partial nephrectomy was carried out. The pathological diagnosis was peripheral T‐cell lymphoma, not otherwise specified. He has been followed for 20 months after robotic‐assisted partial nephrectomy without additional treatment and recurrence.ConclusionWe experienced a primary renal peripheral T‐cell lymphoma, not otherwise specified that was followed up without treatment after surgery.
In‐network computing—challenges and opportunities
Authors: Silva Rui , Corujo Daniel , Quevedo José , Aguiar Rui 
Published: October 2023

AbstractThe rapid growth of new applications with high resource demands leads to the need for more computing power. Datacenter servers may not be the most efficient way to run the necessary software. The introduction of programmable dataplanes opens up the possibility to run software directly in the dataplane with lower latency and higher energy efficiency than general purpose servers. Thus, the concept of in‐network computing is introduced. This paper addresses the challenges associated with executing software resorting to programmable networking devices while presenting a high level conceptual architecture including three layers of computing. The paper ends by taking the evaluated challenges into consideration and proposing future research directions for the evolution of the in‐network computing technology.
Therapeutic plasma exchange for mechanical red cell hemolysis: A case series
Authors: Douglas Chloe E. , House Taylor R. , Yalon Larissa , Menon Shina 
Published: October 2023

AbstractWe present three cases of severely elevated plasma free hemoglobin (PFH) in pediatric patients on mechanical circulatory support devices at a tertiary pediatric care center. Due to severe levels of PFH in the setting of critical illness with the inability to pursue immediate mechanical device exchange, membrane filtration therapeutic plasma exchange (TPE) was performed, which resulted in a lowering of PFH levels. However, long‐term outcomes were heterogeneous across the cases. This case series reviews patient presentation, organ function before and after TPE, and the overall role of TPE as an effective treatment option to decrease severely elevated PFH levels. In doing so, we hope to add to what is known about the use of TPE for mechanical red cell hemolysis and provide guidance on its use in critically ill patients.
Mimicry in misophonia: A large‐scale survey of prevalence and relationship with trigger sounds
Authors: Ash Paris A. , Benzaquén Ester , Gander Phillip E. , Berger Joel I. , Kumar Sukhbinder 
Published: October 2023

AbstractBackgroundMisophonia is often referred to as a disorder that is characterized by excessive negative emotional responses, including anger and anxiety, to “trigger sounds” which are typically day‐to‐day sounds, such as those generated from people eating, chewing, and breathing. Misophonia (literally “hatred of sounds”) has commonly been understood within an auditory processing framework where sounds cause distress due to aberrant processing in the auditory and emotional systems of the brain. However, a recent proposal suggests that it is the perceived action (e.g., mouth movement in eating/chewing sounds as triggers) of the trigger person, and not the sounds per se, that drives the distress in misophonia. Since observation or listening to sounds of actions of others are known to prompt mimicry in perceivers, we hypothesized that mimicking the action of the trigger person may be prevalent in misophonia. Apart from a few case studies and anecdotal information, a relation between mimicking and misophonia has not been systematically evaluated.MethodIn this work, we addressed this limitation by collecting data on misophonia symptoms and mimicry behavior using online questionnaires from 676 participants.ResultsAnalysis of these data shows that (i) more than 45% of individuals with misophonia reported mimicry, indicating its wide prevalence, (ii) the tendency to mimic varies in direct proportion to misophonia severity, (iii) compared to other human and environmental sounds, trigger sounds of eating and chewing are more likely to trigger mimicking, and (iv) the act of mimicking provides some degree of relief from distress to people with misophonia.ConclusionThis study shows prevalence of mimicry and its relation to misophonia severity and trigger types. The theoretical framework of misophonia needs to incorporate the phenomenon of mimicry and its effect on management of misophonia distress.
Treatment of Alec: “History does not have to repeat itself”
Authors: Weinberg Igor 
Published: October 2023

AbstractTreatment of patients with pathological narcissism presents several challenges and there is paucity of published case reports that document meaningful and durable change in patients suffering from this condition. Using descriptive and atheoretical language, this paper presents a treatment of a young man in his transition from young adulthood to middle adulthood while he was negotiating complex residues of his experiences of growing up along with developmental challenges related to work and love. Against the backdrop of these transitions, the patient was working through various aspects of functioning related to pathological narcissism. Initially, given academic pressures and past romantic disappointments, he was confronting issues related to perfectionism, self‐criticism, and avoidance. While he was able to move past some of these dynamics and function academically, later challenges related to becoming an independent adult led to a retreat into an avoidant state of futility and pessimism. Working through painful family dynamics related to not being seen and controlled, along with a deepening attachment in therapy as well as confrontation with realities of his life, led him to take steps toward greater independence. Thereafter, his treatment focused on learning from life experiences such as a newly developed career and romantic life, accepting the complexity of self and others, and tolerating disillusionments.
A misinterpreted psychoanalyst: Herbert Silberer and his theory of symbol‐formation
Authors: Gyimesi Júlia 
Published: October 2023

AbstractThe primary aim of this article is to give a more detailed exposition of the cultural, personal, and theoretical contexts in which the Viennese psychoanalyst, Herbert Silberer's theories were born. When assessing the broader picture that this approach offers, it can be concluded that Silberer was an innovative thinker who inspired several of his contemporaries. Recognized in many respects by the society and scholars of this time, he represented quite a different viewpoint that was significantly influenced by several forms of Western esoteric thinking. Yet his main aim was to contribute to the field of psychoanalysis and develop a theory in which rationalistic psychoanalytic interpretations were combined with nonreductive approaches to mystical experiences. Silberer's name is frequently mentioned in a specific context in which his tragic suicide is emphasized rather than his innovations. Upon evaluating the materials recording Silberer's private life, it seems very likely that his suicide was not triggered by the criticism of Freud alone. Silberer's family affairs, his relationship with his father, and his financial and professional struggles could have all contributed to his tragic decision. This paper contends that Silberer'soeuvredeserves greater attention and must be evaluated based upon its own merit.
Measuring the performance of HIV self‐testing at private pharmacies in Kenya: a cross‐sectional study
Authors: Ortblad Katrina F. , Kwach Benn , Zhang Shengruo , Asewe Magdalene , Ongwen Patricia Atieno , Malen Rachel C. , Harkey Kendall , Odoyo Josephine , Gathii Paul , Rota Greshon , Sharma Monisha , Were Daniel Knight , Ngure Kenneth , Omollo Victor , Bukusi Elizabeth Anne 
Published: October 2023

AbstractIntroductionHIV self‐testing (HIVST) has the potential to support daily oral pre‐exposure prophylaxis (PrEP) delivery in private pharmacies, but many national guidelines have not approved HIVST for PrEP dispensing. In Kenya, pharmacy providers are permitted to deliver HIVST, but often do not have the required certification to deliver rapid diagnostic testing (RDT). We estimated the performance of provider‐delivered HIVST compared to RDT, the standard of care for PrEP delivery, at private pharmacies in Kenya to inform decisions on the use of HIVST for PrEP scale‐up.MethodsAt 20 pharmacies in Kisumu County, we trained pharmacy providers (pharmacists and pharmaceutical technologists) on blood‐based HIVST use and client assistance (if requested). We recruited pharmacy clients purchasing sexual and reproductive health‐related products (e.g. condoms) and enrolled those ≥18 years with self‐reported behaviours associated with HIV risk. Enrolled clients received HIVST with associated provider counselling, followed by RDT by a certified HIV testing services (HTS) counsellor. Pharmacy providers and clients independently interpreted HIVST results prior to RDT (results interpreted only by the HTS counsellor). We calculated the sensitivity and specificity of pharmacy provider‐delivered HIVST compared to HTS counsellor‐administered RDT.ResultsBetween March and June 2022, we screened 1691 clients and enrolled 1500; 64% (954/1500) were female and the median age was 26 years (IQR 22–31). We additionally enrolled 40 providers; 42% (17/40) were pharmacy owners and their median years of experience was 6 (IQR 4–10). The majority (79%, 1190/1500) of clients requested provider assistance with HIVST and providers spent a median of 20 minutes (IQR 15–43) with each HIVST client. The sensitivity of provider‐delivered HIVST at the pharmacy was high when interpreted by providers (98.5%, 95% CI 97.8%, 99.1%) and clients (98.8%, 95% CI 98.0%, 99.3%), as was the specificity of HIVST in this setting (provider‐interpretation: 96.9%, 95% CI 89.2%, 99.6%; client‐interpretation: 93.8%, 95% CI 84.8%, 98.3%).ConclusionsWhen compared to the national HIV testing algorithm, provider‐delivered blood‐based HIVST at private pharmacies in Kenya performed well. These findings suggest that blood‐based HIVST may be a useful tool to support PrEP initiation and continuation at private pharmacies and potentially other community‐based delivery settings.
Non‐enzymatic glycation and aggregation of camel immunoglobulins induce breast cancer cell proliferation
Authors: Alafaleq Nouf O. , Alruwaished Ghaida I. , Khan Mohd Shahnawaz , Al‐Shouli Samia T. , Mujamammi Ahmed H. , Sabi Essa M. , Sumaily Khalid M. , Almansour Mohammed , Alokail Majed S. 
Published: October 2023

AbstractGlycation of biomolecules results in the formation of advanced glycation end products (AGEs). Immunoglobulin G (IgG) has been implicated in the progression of various diseases, including diabetes and cancer. This study purified three IgG subclasses (IgG1, IgG2, and IgG3) from Camelus dromedarius colostrum using ammonium sulfate fractionation and chromatographic procedures. SDS‐PAGE was performed to confirm the purity and molecular weight of the IgG subclasses. Several biochemical and biophysical techniques were employed to study the effect of glycation on camel IgG using methylglyoxal (MGO), a dicarbonyl sugar. Early glycation measurement showed an increase in the fructosamine content by ~four‐fold in IgG2, ~two‐fold in IgG3, and a slight rise in IgG1. AGEs were observed in all classes of IgGs with maximum hyperchromicity (96.6%) in IgG2. Furthermore, glycation‐induced oxidation of IgGs led to an increase in carbonyl content and loss of ‐SH groups. Among subclass, IgG2 showed the highest (39.7%) increase in carbonyl content accompanied by 82.5% decrease in ‐SH groups. Far UV‐CD analysis illustrated perturbation of β‐sheet structure during glycation reaction with MGO. Moreover, glycation of IgG proceeds to various conformational states like aggregation and increased hydrophobicity. In addition, the cytotoxicity assay (MTT) illustrated the proliferation of breast cancer cells (MCF‐7) with IgG2 treatment.
The Role of Improved Motion‐Sensitized Driven Equilibrium Blood Suppression and Fat Saturation on T2 Relaxation Time, Using GraSE Sequence in Cardiac Magnetic Resonance Imaging
Authors: Hammood Ebtihal Raheem , Shirani Shapoor , Sadri Ali , Bahri Mousa , Dehghani Sadegh 
Published: October 2023

BackgroundT2 mapping is a valuable technique in cardiac MR imaging that offers insights into the microstructural characteristics of myocardial tissue. However, it was shown that myocardial T2 relaxation times (T2) measured vary significantly depending on sequence, sequence parameters, and field strength.PurposeTo assess T2 variability and image quality in cardiac T2 maps using four variants of the gradient‐spin echo (GraSE) sequence, having different methods of blood signal suppression (double inversion recovery (DIR) and improved motion‐sensitized driven equilibrium (iMSDE) and with and without the addition of fat saturation (FS).Study TypeProspective.Population48 healthy volunteers (46.7 +/− 21.5 years, 24 male) with no cardiac history.Field Strength/SequenceGraSE sequence with DIR (GraSEDIR), with iMSDE (GraSEiMSDE) and FS (GraSEDIR‐FS) and with both iMSDE and FS (GraSEiMSDE‐FS) at 1.5T.AssessmentGlobal T2 from three short axis myocardial slices. and image quality assessments using a 5‐point Lickert scale (1, (non‐diagnostic) to 5, (excellent)) were conducted to evaluate the impact of DB and FS techniques on myocardial T2 measurements and image quality.Statistical TestsPaired t‐tests or non‐parametric equivalents for comparisons between sequences. The Bland–Altmann plots and Pearson rank correlation analyses, as appropriate. A P value <0.05 was considered statistically significant.ResultsThe mean global T2 values for GraSEDIR, GraSEDIR‐FS, GraSEiMSDE, and GraSEiMSDE‐FS, were 52.84 ± 5.72 msec, 54.98 ± 3.59 msec, 53.9 ± 4.05 msec, and 55.14 ± 4.28 msec, respectively, with no significant differences (P = 0.092). High image quality scores (>4 out of 5) were obtained for all sequence variants with no significant differences between them (P = 0.11).Data ConclusionAll GraSE sequence variants exhibited approximately the same results and variations in the DB technique and addition of FS did not have significant impact on myocardial T2 values.Level of Evidence2Technical EfficacyStage 1
Stand‐off Raman spectroscopy is a promising approach for the detection and identification of bloodstains for forensic purposes
Authors: Almehmadi Lamyaa M. , Lednev Igor K. 
Published: October 2023

AbstractStand‐off Raman spectroscopy combined with chemometrics was demonstrated to have great potential for detecting and identifying biological stains from a distance for forensic purposes. Bloodstain spectra were collected using a handheld Raman spectrometer equipped with a stand‐off attachment and compared with spectra acquired with a benchtop Raman microscope. The two sets of spectra were visually similar, supporting the potential use of a handheld Raman spectrometer with stand‐off attachment for blood detection at the scene of crime. In addition, the stand‐off Raman spectra of bloodstains were correctly identified using a previously built SVM‐DA model for the identification of all main body fluids (Muro et al., Forensic Chemistry, 2016). Stand‐off Raman spectroscopy opens a new potential opportunity for further development of Raman spectroscopy as a universal tool for detecting and identifying body fluid traces for forensic purposes.
Research progress on the regulation of oxidative stress by phenolics: the role of gut microbiota and Nrf2 signaling pathway
Authors: Liu Yanxia , Wang Xiaoling , Podio Natalia S. , Wang Xiaoyin , Xu Shuyan , Jiang Suhang , Wei Xia , Han Yuna , Cai Yunyan , Chen Xingyu , Jin Fan , Li Xianbao , Gong Er Sheng 
Published: October 2023

AbstractIn recent years, the increase in high‐calorie diets and sedentary lifestyles has made obesity a global public health problem. An unbalanced diet promotes the production of proinflammatory cytokines and causes redox imbalance in the body. Phenolics have potent antioxidant activity and cytoprotective ability. They can scavenge free radicals and reactive oxygen species, and enhance the activity of antioxidant enzymes, thus combating the body's oxidative stress. They can also improve the body's inflammatory response, enhance the enzyme activity of lipid metabolism, and reduce the contents of cholesterol and triglyceride. Most phenolics are biotransformed and absorbed into the blood after the action by gut microbiota; these metabolites then undergo phase I and II metabolism and regulate oxidative stress by scavenging free radicals and increasing expression of antioxidant enzymes. Phenolics induce the expression of genes encoding antioxidant enzymes and phase II detoxification enzymes by stimulating Nrf2 to enter the nucleus and bind to the antioxidant response element after uncoupling from Keap1, thereby promoting the production of antioxidant enzymes and phase II detoxification enzymes. The absorption rate of phenolics in the small intestine is extremely low. Most phenolics reach the colon, where they interact with the microbiota and undergo a series of metabolism. Their metabolites will reach the liver via the portal vein and undergo conjugation reactions. Subsequently, the metabolites reach the whole body to exert biological activity by traveling with the systemic circulation. Phenolics can promote the growth of probiotics, reduce the ratio of Firmicutes/Bacteroidetes (F/B), and improve intestinal microecological imbalance. This paper reviews the nutritional value, bioactivity, and antioxidant mechanism of phenolics in the body, aiming to provide a scientific basis for the development and utilization of natural antioxidants and provide a reference for elucidating the mechanism of action of phenolics for regulating oxidative stress in the body. © 2023 Society of Chemical Industry.
High symptom burden in patients undergoing gastrectomy for cancer
Authors: Lilley Elizabeth J. , Lu Pamela , Robinson Kristen , Griffith Heather , Mansfield Paul , Ikoma Naruhiko , Badgwell Brian D. 
Published: October 2023

AbstractBackgroundThere is little data describing symptom burden before or after gastrectomy for patients with cancer. We aimed to examine the perioperative patterns of symptom severity in patients undergoing gastrectomy.MethodsIn this single‐institution prospective cohort study, patients scheduled to undergo gastrectomy for cancer completed serial symptom measurement questionnaires preoperatively, at postoperative day (POD) 1–3, and POD 4–7. The percent of patients with moderate to severe scores was calculated at each time point.ResultsThirty‐nine patients completed 94 surveys. Preoperatively, 46% reported at least one moderate/severe symptom. This increased to 88% during POD 1–3 and 79% during POD 4–7. During the preoperative period, 25% of patients reported moderate to severe interference in at least one aspect of daily life. This increased to 73% of patients at both POD 1–3 and POD 4–7.ConclusionsPatients undergoing gastrectomy for cancer frequently experience symptoms that interfere with daily life. A better understanding of these symptoms may improve patients' experiences with, and recovery from, gastrectomy.
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research
Authors: Zhou Minhao , Theologis Alekos A. , O’Connell Grace D. 
Published: October 2023

AbstractLumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss, and disability, is a common musculoskeletal disorder that results in significant socioeconomic burdens. Despite extensive clinical and basic scientific research efforts, herniation etiopathogenesis, particularly its initiation and progression, is not well understood. Understanding herniation etiopathogenesis is essential for developing effective preventive measures and therapeutic interventions. Thus, this review seeks to provide a thorough overview of the advances in herniation‐oriented research, with a discussion on ongoing challenges and potential future directions for clinical, translational, and basic scientific investigations to facilitate innovative interdisciplinary research aimed at understanding herniation etiopathogenesis. Specifically, risk factors for herniation are identified and summarized, including familial predisposition, obesity, diabetes mellitus, smoking tobacco, selected cardiovascular diseases, disc degeneration, and occupational risks. Basic scientific experimental and computational research that aims to understand the link between excessive mechanical load, catabolic tissue remodeling due to inflammation or insufficient nutrient supply, and herniation, are also reviewed. Potential future directions to address the current challenges in herniation‐oriented research are explored by combining known progressive development in existing research techniques with ongoing technological advances. More research on the relationship between occupational risk factors and herniation, as well as the relationship between degeneration and herniation, is needed to develop preventive measures for working‐age individuals. Notably, researchers should explore using or modifying existing degeneration animal models to study herniation etiopathogenesis, as such models may allow for a better understanding of how to prevent mild‐to‐moderately degenerated discs from herniating.