bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease
Authors: Hu Shixian , Bourgonje Arno R. , Gacesa Ranko , Jansen Bernadien H. , Björk Johannes R. , Bangma Amber , Hidding Iwan J. , van Dullemen Hendrik M. , Visschedijk Marijn C. , Faber Klaas Nico , Dijkstra Gerard , Harmsen Hermie J. M. , Festen Eleonora A. M. , Vich Vila Arnau , Spekhorst Lieke M. , Weersma Rinse K. 
Published: February 2024

AbstractDisrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specific interactions, we perform transcriptomic (RNA-seq) and microbial (16S-rRNA-seq) profiling of 697 intestinal biopsies (645 derived from 335 patients with IBD and 52 from 16 non-IBD controls). Mucosal gene expression patterns in IBD are mainly determined by tissue location and inflammation, whereas the mucosal microbiota composition shows a high degree of individual specificity. Analysis of transcript-bacteria interactions identifies six distinct groups of inflammation-related pathways that are associated with intestinal microbiota (adjusted P < 0.05). An increased abundance of Bifidobacterium is associated with higher expression of genes involved in fatty acid metabolism, while Bacteroides correlates with increased metallothionein signaling. In patients with fibrostenosis, a transcriptional network dominated by immunoregulatory genes is associated with Lachnoclostridium bacteria in non-stenotic tissue (adjusted P < 0.05), while being absent in CD without fibrostenosis. In patients using TNF-α-antagonists, a transcriptional network dominated by fatty acid metabolism genes is linked to Ruminococcaceae (adjusted P < 0.05). Mucosal microbiota composition correlates with enrichment of intestinal epithelial cells, macrophages, and NK-cells. Overall, these data demonstrate the presence of context-specific mucosal host-microbe interactions in IBD, revealing significantly altered inflammation-associated gene-taxa modules, particularly in patients with fibrostenotic CD and patients using TNF-α-antagonists. This study provides compelling insights into host–microbe interactions that may guide microbiota-directed precision medicine and fuels the rationale for microbiota-targeted therapeutics as a strategy to alter disease course in IBD.
A compressive hyperspectral video imaging system using a single-pixel detector
Authors: Xu Yibo , Lu Liyang , Saragadam Vishwanath , Kelly Kevin F. 
Published: February 2024

AbstractCapturing fine spatial, spectral, and temporal information of the scene is highly desirable in many applications. However, recording data of such high dimensionality requires significant transmission bandwidth. Current computational imaging methods can partially address this challenge but are still limited in reducing input data throughput. In this paper, we report a video-rate hyperspectral imager based on a single-pixel photodetector which can achieve high-throughput hyperspectral video recording at a low bandwidth. We leverage the insight that 4-dimensional (4D) hyperspectral videos are considerably more compressible than 2D grayscale images. We propose a joint spatial-spectral capturing scheme encoding the scene into highly compressed measurements and obtaining temporal correlation at the same time. Furthermore, we propose a reconstruction method relying on a signal sparsity model in 4D space and a deep learning reconstruction approach greatly accelerating reconstruction. We demonstrate reconstruction of 128 × 128 hyperspectral images with 64 spectral bands at more than 4 frames per second offering a 900× data throughput compared to conventional imaging, which we believe is a first-of-its kind of a single-pixel-based hyperspectral imager.
ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy
Authors: Sasaki Taeko , Kushida Yasuharu , Norizuki Takuya , Kosako Hidetaka , Sato Ken , Sato Miyuki 
Published: February 2024

AbstractAllophagy is responsible for the selective removal of paternally inherited organelles, including mitochondria, in Caenorhabditis elegans embryos, thereby facilitating the maternal inheritance of mitochondrial DNA. We previously identified two key factors in allophagy: an autophagy adaptor allophagy-1 (ALLO-1) and TBK1/IKKε family kinase IKKE-1. However, the precise mechanisms by which ALLO-1 and IKKE-1 regulate local autophagosome formation remain unclear. In this study, we identify two ALLO-1 isoforms with different substrate preferences during allophagy. Live imaging reveals a stepwise mechanism of ALLO-1 localization with rapid cargo recognition, followed by ALLO-1 accumulation around the cargo. In the ikke-1 mutant, the accumulation of ALLO-1, and not the recognition of cargo, is impaired, resulting in the failure of isolation membrane formation. Our results also suggest a feedback mechanism for ALLO-1 accumulation via EPG-7/ATG-11, a worm homolog of FIP200, which is a candidate for IKKE-1-dependent phosphorylation. This feedback mechanism may underlie the ALLO-1-dependent initiation and progression of autophagosome formation around paternal organelles.
Promoting high-voltage stability through local lattice distortion of halide solid electrolytes
Authors: Song Zhenyou , Wang Tengrui , Yang Hua , Kan Wang Hay , Chen Yuwei , Yu Qian , Wang Likuo , Zhang Yini , Dai Yiming , Chen Huaican , Yin Wen , Honda Takashi , Avdeev Maxim , Xu Henghui , Ma Jiwei , Huang Yunhui , Luo Wei 
Published: February 2024

AbstractStable solid electrolytes are essential to high-safety and high-energy-density lithium batteries, especially for applications with high-voltage cathodes. In such conditions, solid electrolytes may experience severe oxidation, decomposition, and deactivation during charging at high voltages, leading to inadequate cycling performance and even cell failure. Here, we address the high-voltage limitation of halide solid electrolytes by introducing local lattice distortion to confine the distribution of Cl−, which effectively curbs kinetics of their oxidation. The confinement is realized by substituting In with multiple elements in Li3InCl6 to give a high-entropy Li2.75Y0.16Er0.16Yb0.16In0.25Zr0.25Cl6. Meanwhile, the lattice distortion promotes longer Li-Cl bonds, facilitating favorable activation of Li+. Our results show that this high-entropy halide electrolyte boosts the cycle stability of all-solid-state battery by 250% improvement over 500 cycles. In particular, the cell provides a higher discharge capacity of 185 mAh g−1 by increasing the charge cut-off voltage to 4.6 V at a small current rate of 0.2 C, which is more challenging to electrolytes|cathode stability. These findings deepen our understanding of high-entropy materials, advancing their use in energy-related applications.
Iron-catalyzed fluoroalkylative alkylsulfonylation of alkenes via radical-anion relay
Authors: Hou Xiaoya , Liu Hongchi , Huang Hanmin 
Published: February 2024

AbstractTransition metal-catalyzed reductive difunctionalization of alkenes with alkyl halides is a powerful method for upgrading commodity chemicals into densely functionalized molecules. However, super stoichiometric amounts of metal reductant and the requirement of installing a directing group into alkenes to suppress the inherent β-H elimination bring great limitations to this type of reaction. We demonstrate herein that the difunctionalization of alkenes with two different alkyl halides is accessible via a radical-anion relay with Na2S2O4 as both reductant and sulfone-source. The Na2S2O4 together with the electron-shuttle catalyst is crucial to divert the mechanistic pathway toward the formation of alkyl sulfone anion instead of the previously reported alkylmetal intermediates. Mechanistic studies allow the identification of carbon-centered alkyl radical and sulfur-centered alkyl sulfone radical, which are in equilibrium via capture or extrusion of SO2 and could be converted to alkyl sulfone anion accelerated by iron electron-shuttle catalysis, leading to the observed high chemoselectivity.
CALPHAD accelerated design of advanced full-Zintl thermoelectric device
Authors: Yin Li , Li Xiaofang , Bao Xin , Cheng Jinxuan , Chen Chen , Zhang Zongwei , Liu Xingjun , Cao Feng , Mao Jun , Zhang Qian 
Published: February 2024

AbstractSince thermoelectric materials have different physical and chemical properties, the design of contact layers requires dedicated efforts, and the welding temperatures are distinctly different. Therefore, a general interface design and connection technology can greatly facilitate the development of thermoelectric devices. Herein, we proposed a screening strategy for the contact materials based on the calculation of phase diagram method, and Mg2Ni has been identified as a matched contact layer for n-type Mg3Sb2-based materials. And this screening strategy can be effectively applied to other thermoelectric materials. By adopting the low-temperature sintering silver nanoparticles technology, the Zintl phase thermoelectric device can be fabricated at low temperature but operate at medium temperature. The single-leg n-type Mg3.15Co0.05SbBi0.99Se0.01 device achieves an efficiency of ~13.3%, and a high efficiency of ~11% at the temperature difference of 430 K has been realized for the Zintl phase thermoelectric device comprised together with p-type Yb0.9Mg0.9Zn1.198Ag0.002Sb2. Additionally, the thermal aging and thermal cycle experiments proved the long-term reliability of the Mg2Ni/Mg3.15Co0.05SbBi0.99Se0.01 interface and the nano-silver sintering joints. Our work paves an effective avenue for the development of advanced devices for thermoelectric power generation.
Continuous ultraviolet to blue-green astrocomb
Authors: Cheng Yuk Shan , Dadi Kamalesh , Mitchell Toby , Thompson Samantha , Piskunov Nikolai , Wright Lewis D. , Gawith Corin B. E. , McCracken Richard A. , Reid Derryck T. 
Published: February 2024

AbstractCosmological and exoplanetary science using transformative telescopes like the ELT will demand precise calibration of astrophysical spectrographs in the blue-green, where stellar absorption lines are most abundant. Astrocombs—lasers providing a broadband sequence of regularly-spaced optical frequencies on a multi-GHz grid—promise an atomically-traceable calibration scale, but their realization in the blue-green is challenging for current infrared-laser-based technology. Here, we introduce a concept achieving a broad, continuous spectrum by combining second-harmonic generation and sum-frequency-mixing in an MgO:PPLN waveguide to generate 390–520 nm light from a 1 GHz Ti:sapphire frequency comb. Using a Fabry-Pérot filter, we extract a 30 GHz sub-comb spanning 392–472 nm, visualizing its thousands of modes on a high-resolution spectrograph. Experimental data and simulations demonstrate how the approach can bridge the spectral gap present in second-harmonic-only conversion. Requiring only $$\approx$$
≈
100 pJ pulses, our concept establishes a new route to broadband UV-visible generation at GHz repetition rates.
Robust temporal adiabatic passage with perfect frequency conversion between detuned acoustic cavities
Authors: Chen Zhao-Xian , Peng Yu-Gui , Chen Ze-Guo , Liu Yuan , Chen Peng , Zhu Xue-Feng , Lu Yan-Qing 
Published: February 2024

AbstractFor classical waves, phase matching is vital for enabling efficient energy transfer in many scenarios, such as waveguide coupling and nonlinear optical frequency conversion. Here, we propose a temporal quasi-phase matching method and realize robust and complete acoustical energy transfer between arbitrarily detuned cavities. In a set of three cavities, A, B, and C, the time-varying coupling is established between adjacent elements. Analogy to the concept of stimulated Raman adiabatic passage, amplitudes of the two couplings are modulated as time-delayed Gaussian functions, and the couplings’ signs are periodically flipped to eliminate temporal phase mismatching. As a result, robust and complete acoustic energy transfer from A to C is achieved. The non-reciprocal frequency conversion properties of our design are demonstrated. Our research takes a pivotal step towards expanding wave steering through time-dependent modulations and is promising to extend the frequency conversion based on state evolution in various linear Hermitian systems to nonlinear and non-Hermitian regimes.
A chromosome-level genome assembly of the forestry pest Coronaproctus castanopsis
Authors: Huang Yi-Xin , Zhu Xiu-Shuang , Chen Xiao-Nan , Zheng Xin-Yi , Su Bao-Shan , Shi Xiao-Yu , Wang Xu , Wu San-An , Hu Hao-Yuan , Yu Jian-Ping , Zhang Yan-Zhou , Zhu Chao-Dong 
Published: February 2024

AbstractAs an important forestry pest, Coronaproctus castanopsis (Monophlebidae) has caused serious damage to the globally valuable Gutianshan ecosystem, China. In this study, we assembled the first chromosome-level genome of the female specimen of C. castanopsis by merging BGI reads, HiFi long reads and Hi-C data. The assembled genome size is 700.81 Mb, with a scaffold N50 size of 273.84 Mb and a contig N50 size of 12.37 Mb. Hi-C scaffolding assigned 98.32% (689.03 Mb) of C. Castanopsis genome to three chromosomes. The BUSCO analysis (n = 1,367) showed a completeness of 91.2%, comprising 89.2% of single-copy BUSCOs and 2.0% of multicopy BUSCOs. The mapping ratio of BGI, second-generation RNA, third-generation RNA and HiFi reads are 97.84%, 96.15%, 97.96%, and 99.33%, respectively. We also identified 64.97% (455.3 Mb) repetitive elements, 1,373 non-coding RNAs and 10,542 protein-coding genes. This study assembled a high-quality genome of C. castanopsis, which accumulated valuable molecular data for scale insects.
Structural effects of asymmetric magnet shape on performance of surface permanent magnet synchronous motors
Authors: Choe Jungwoo , Kwon Hyuksung , Kim Hyunwoo , Koo Doheon , So Hongyun 
Published: February 2024

AbstractThis study proposes a novel surface permanent magnet synchronous motor (N-SPMSM) structure, which features asymmetric magnets attached to the rotor surface. The N-SPMSM structure exhibits reduced structural complexity and minimal electromagnetic performance degradation. The properties of N-SPMSM are analyzed by comparing its structural complexity (in terms of the shape) and manufacturing complexity and electromagnetic performance [in terms of the cogging–mutual torque ratio and back-electromotive force (EMF) values], with the corresponding values of a ring-type SPMSM (R-SPMSM) and step-skew-type SPMSM (T-SPMSM). The analysis results demonstrate that N-SPMSM has lower shape complexity than T-SPMSM and lower manufacturing complexity than both R-SPMSM and T-SPMSM. The cogging torque reduction and back-EMF performances of N-SPMSM are similar to that of R-SPMSM and T-SPMSM.
An efficient energy management scheme using rule-based swarm intelligence approach to support pulsed load via solar-powered battery-ultracapacitor hybrid energy system
Authors: Wasim Muhammad Shahid , Amjad Muhammad , Abbasi Muhammad Abbas , Bhatti Abdul Rauf , Rasool Akhtar , Raheem Abdur , Ali Ahmed , Khan Baseem 
Published: February 2024

AbstractThis work presents an energy management scheme (EMS) based on a rule-based grasshopper optimization algorithm (RB-GOA) for a solar-powered battery-ultracapacitor hybrid system. The main objective is to efficiently meet pulsed load (PL) demands and extract maximum energy from the photovoltaic (PV) array. The proposed approach establishes a simple IF-THEN set of rules to define the search space, including PV, battery bank (BB), and ultracapacitor (UC) constraints. GOA then dynamically allocates power shares among PV, BB, and UC to meet PL demand based on these rules and search space. A comprehensive study is conducted to evaluate and compare the performance of the proposed technique with other well-known swarm intelligence techniques (SITs) such as the cuckoo search algorithm (CSA), gray wolf optimization (GWO), and salp swarm algorithm (SSA). Evaluation is carried out for various cases, including PV alone without any energy storage device, variable PV with a constant load, variable PV with PL cases, and PV with maximum power point tracking (MPPT). Comparative analysis shows that the proposed technique outperforms the other SITs in terms of reducing power surges caused by PV power or load transition, oscillation mitigation, and MPP tracking. Specifically, for the variable PV with constant load case, it reduces the power surge by 26%, 22%, and 8% compared to CSA, GWO, and SSA, respectively. It also mitigates oscillations twice as fast as CSA and GWO and more than three times as fast as SSA. Moreover, it reduces the power surge by 9 times compared to CSA and GWO and by 6 times compared to SSA in variable PV with the PL case. Furthermore, its MPP tracking speed is approximately 29% to 61% faster than its counterparts, regardless of weather conditions. The results demonstrate that the proposed EMS is superior to other SITs in keeping a stable output across PL demand, reducing power surges, and minimizing oscillations while maximizing the usage of PV energy.
Application of the performance of machine learning techniques as support in the prediction of school dropout
Authors: Jiménez-Gutiérrez Auria Lucia , Mota-Hernández Cinthya Ivonne , Mezura-Montes Efrén , Alvarado-Corona Rafael 
Published: February 2024

AbstractThis article presents a study, intending to design a model with 90% reliability, which helps in the prediction of school dropouts in higher and secondary education institutions, implementing machine learning techniques. The collection of information was carried out with open data from the 2015 Intercensal Survey and the 2010 and 2020 Population and Housing censuses carried out by the National Institute of Statistics and Geography, which contain information about the inhabitants and homes. in the 32 federal entities of Mexico. The data were homologated and twenty variables were selected, based on the correlation. After cleaning the data, there was a sample of 1,080,782 records in total. Supervised learning was used to create the model, automating data processing with training and testing, applying the following techniques, Artificial Neural Networks, Support Vector Machines, Linear Ridge and Lasso Regression, Bayesian Optimization, Random Forest, the first two with a reliability greater than 99% and the last with 91%.
Coupling vibration analysis of heat exchanger tube bundles under different stiffness conditions
Authors: Yin Yifang , Wang Zunce , Ma Mingyue , Zhang Jinglong , Xu Yan , Li Lidong , Ge Mingming 
Published: February 2024

AbstractA two-dimensional tube bundles fluid–structure coupling model was developed using the CFD approach, with a rigid body motion equation and the Newmark integral method. The numerical simulations were performed to determine the vibration coupling properties between various tube bundles of stiffness. Take the corner square tube bundles with a pitch ratio of 1.28 as the research object. The influence of adjacent tubes with different stiffness on the vibration of the central target tube was analyzed. The research results show that the vibration characteristic of tube bundles is affected by the flow field dominant frequency and the inherent frequency of tube bundles. The vibration of adjacent tube bundles significantly impacts the amplitude and frequency of the central target tube. The equal stiffness and large stiffness tubes upstream or downstream inhibit the vibration displacement of the target tube to some extent. The low-stiffness tubes upstream or downstream significantly enhanced the amplitude of the target tube. The findings can be used to provide a basis for reasonable design and vibration suppression of shell-and-tube heat exchangers.
Transcutaneous cervical vagus nerve stimulation improves sensory performance in humans: a randomized controlled crossover pilot study
Authors: Jigo Michael , Carmel Jason B. , Wang Qi , Rodenkirch Charles 
Published: February 2024

AbstractAccurate senses depend on high-fidelity encoding by sensory receptors and error-free processing in the brain. Progress has been made towards restoring damaged sensory receptors. However, methods for on-demand treatment of impaired central sensory processing are scarce. Prior invasive studies demonstrated that continuous vagus nerve stimulation (VNS) in rodents can activate the locus coeruleus-norepinephrine system to rapidly improve central sensory processing. Here, we investigated whether transcutaneous VNS improves sensory performance in humans. We conducted three sham-controlled experiments, each with 12 neurotypical adults, that measured the effects of transcutaneous VNS on metrics of auditory and visual performance, and heart rate variability (HRV). Continuous stimulation was delivered to cervical (tcVNS) or auricular (taVNS) branches of the vagus nerve while participants performed psychophysics tasks or passively viewed a display. Relative to sham stimulation, tcVNS improved auditory performance by 37% (p = 0.00052) and visual performance by 23% (p = 0.038). Participants with lower performance during sham conditions experienced larger tcVNS-evoked improvements (p = 0.0040). Lastly, tcVNS increased HRV during passive viewing, corroborating vagal engagement. No evidence for an effect of taVNS was observed. These findings validate the effectiveness of tcVNS in humans and position it as a method for on-demand interventions of impairments associated with central sensory processing dysfunction.
Mean corpuscular volume as a prognostic factor for 30-day mortality in major trauma patients: a retrospective cohort study
Authors: Choi Hanlim , Lee Jin Young , Sul Younghoon , Kim Se Heon , Ye Jin Bong , Lee Jin Suk , Yoon Soo Young , Seok Junepill , Choi Jung Hee 
Published: February 2024

AbstractWe investigated the clinical implications of the mean corpuscular volume (MCV) in patients with major trauma. This single-center retrospective review included 2021 trauma patients admitted to the intensive care unit between January 2016 and June 2020. We included 1218 patients aged $$\ge $$
≥
18 years with an injury severity score $$\ge $$
≥
16 in the final analysis. The clinical and laboratory variables were compared between macrocytosis (defined as MCV $$\ge $$
≥
100 fL) and non-macrocytosis groups. Cox regression analysis was performed to calculate the hazard ratios (HRs) of variables for 30-day mortality, with adjustment for other potential confounding factors. The initial mean value of MCV was 102.7 fL in the macrocytosis group (n = 199) and 93.7 fL in the non-macrocytosis group (n = 1019). The macrocytosis group showed a significantly higher proportion of initial hypotension, transfusion within 4 and 24 h, and 30-day mortality than the non-macrocytosis group. Age ($$\ge $$
≥
65 years), hypotension (systolic blood pressure $$\le $$
≤
90 mmHg), transfusion (within 4 h), anemia (Hb < 12 g/day in women, < 13 g/day in men), and macrocytosis were significantly associated with 30-day mortality (adjusted HR = 1.4; 95% confidence interval 1.01–1.94; p = 0.046) in major trauma patients. Thus, initial macrocytosis independently predicted 30-day mortality in patients with major trauma at a Level I trauma center.