bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal relationship from heart failure to kidney function and CKD: A bidirectional two-sample mendelian randomization study
Authors: Zhang Junyu , Hu Zhixi , Tan Yuquan , Ye Jiahao 
Published: December 2023

Background
Heart Failure (HF) is a widespread condition that affects millions of people, and it is caused by issues with the heart and blood vessels. Even though we know hypertension, coronary artery disease, obesity, diabetes, and genetics can increase the risk of HF and Chronic Kidney Disease (CKD), the exact cause of these conditions remains a mystery. To bridge this gap, we adopted Mendelian Randomization (MR), which relies on genetic variants as proxies.

Methods
We used data from European populations for our Bidirectional Two-Sample MR Study, which included 930,014 controls and 47,309 cases of HF from the HERMES consortium, as well as 736,396 controls and 51,256 cases of CKD. We also employed several MR variations, including MR-Egger, Inverse Variance Weighted (IVW), and Weighted Median Estimator (WME), to guarantee the results were accurate and comprehensive.).

Results
In this study, the MR analysis found that individuals with a genetic predisposition for HF have an elevated risk of CKD. Our study revealed a significant association between the genetic prediction of HF and the risk of CKD, as evidenced by the IVW method [with an odds ratio (OR) of 1.12 (95% CI, 1.03–1.21), p = 0.009] and the WME [with an OR of 1.14 (95% CI, 1.03–1.26), p = 0.008]. This causal relationship remained robust even after conducting MR analysis while adjusting for the effects of diabetes and hypertension, yielding ORs of 1.13 (IVW:95% CI, 1.03–1.23), 1.12 (MR-Egger: 95% CI, 0.85–1.48), and 1.15 (WME:95% CI, 1.04–1.27) (p = 0.008). However, in the reverse analysis aiming to explore CKD and renal function as exposures and HF as the outcome, we did not observe a statistically significant causal link between CKD and HF.

Conclusion
Our study demonstrates the significance of HF in CKD progression, thus having meaningful implications for treatment and the potential for discovering new therapies. To better understand the relationship between HF and CKD, we need to conduct research in a variety of populations.
O livro e a revolução digital: um panorama a partir de John B. Thompson
Authors: Feronato Lavinia , Depexe Sandra 
Published: December 2023

O seguinte texto trata de uma resenha crítica a respeito da obra de John B. Thompson de 2021: "As Guerras do Livro: A revolução digital no mercado editorial" publicada pela editora Unesp.
THEORETICAL ASPECTS OF DEVELOPMENT OF THE CONCEPTUAL FOUNDATIONS OF CONTROLLING
Authors: Gvozdeva E. A. 
Published: December 2023

The situation of economic uncertainty dictates the need to apply progressive approaches to management, which include controlling. The study of the evolution of views on controlling is necessary for an objective assessment of the current state of this concept, the prospects for its development in domestic enterprises.
The article presents the theoretical aspects of the formation of the concept of controlling, reflects the views of the most famous foreign and domestic researchers in the field of controlling regarding the essence of this category. The systematization of approaches to the definition of the concept of “controlling” is given, the author's approach to interpreting this concept is proposed, taking into account modern trends in the development of management theory and practice. Formulating the definition of the concept of “controlling”, the author focuses on the relationship between the concept of controlling and process management.
INVESTIGATION OF THE DYNAMICS OF RETAIL TRADE TURNOVER AND PUBLIC CATERING IN MOSCOW IN THE CONDITIONS OF TURBULENCE OF THE EXTERNAL ENVIRONMENT
Authors: Suray N. M. , Tatochenko I. M. , Ponomareva N. V. 
Published: December 2023

The article examines the dynamics of retail trade and catering turnover in the largest metropolis of Russia — Moscow. The authors found that both indicators respond quickly and clearly to changes in the external environment.
Based on the analysis of time series of 2015–2022 indicators, the disturbing effect of economic sanctions, the
Covid-19 pandemic, as well as a special military operation is estimated. The high ability of economic indicators to recover quickly (within a year) after the cessation of disturbing influences has been confirmed. Using the correlation matrix method, close relationships between the variables of time, average salary, retail trade turnover and catering were revealed. Regression equations linking these variables are obtained, after which the effect of retail and catering turnover growth caused by an increase in wages is quantified. The obtained regression equations can be used to predict the values of the considered variables on the horizon the lead time is 2–3 years. The growth of the turnover of Moscow public catering is ensured thanks to the development of the social nutrition system. With its further development, it is advisable to adjust the assortment policy, focusing on a broader offer of dairy products to visitors, since their consumption by Russians has not yet reached the rational norm.
BUSINESS ACTIVITY IN THE REGIONS OF THE RUSSIAN FEDERATION
Authors: Trofimova N. V. 
Published: December 2023

Small and medium-sized enterprises (SMEs) in the socio-economic development of any country serve as a kind of trigger and generator of structural changes in the economy and society. Small businesses are the most receptive to innovative ideas and are ready to implement them. On the one hand, small and medium-sized businesses act as a catalyst for the economic growth of the entire country, on the other hand, they implement a number of social tasks, the key of which is to promote employment and ensure a decent standard of living for citizens. The SME sector employs more than 25 % of the country's able-bodied population. At the same time, the constituent entities of the Russian Federation are seriously differentiated in terms of the level of development of SMEs, in some regions the potential of the SMEs is used inefficiently.
Given the current conditions for the functioning of the Russian economy and the fact that small and mediumsized businesses play an important role in its development, the study of the level of entrepreneurial activity in the constituent entities of the Russian Federation and the search for ways to increase it is very relevant.
The article carried out the clustering of the constituent entities of the Russian Federation according to indicators of business demography (“birth rate”, liquidation of organizations), entrepreneurial activity, as well as an indicator reflecting the current opportunities for expanding entrepreneurial potential in the constituent entities of the Russian Federation. The place of the Republic of Bashkortostan among other subjects of the Russian Federation in terms of the level of entrepreneurial activity has been determined.
Viele Wahrheiten in der Planung? Anmerkungen zu Ideen der Postmoderne in der Planungstheorie
Authors: Lintz Gerd 
Published: December 2023

In a recently published essay on planning theory, Benjamin Davy, Meike Levin-Keitel and Franziska Sielker observe a “brutal plurality of truths” that complicates spatial planning. In particular, they ask how planners can deal with this. Against the backdrop of the climate and biodiversity crisis, the commentary takes this essay as an opportunity to take a critical look at the multiplicity of truths postulated by postmodernism and the correspondingly stretched concept of knowledge. Above all, it points out the great importance of the pursuit of truth (in the singular) for society. Moreover, it emphasises the danger of making inter- and transdisciplinary research more difficult, of depreciating science and of increasing the distance between science and the centre of society. The commentary pleads for a faster, stronger focus on the very big challenges of our time, for which a pragmatic orientation towards truth and what unites society is indispensable.
Prispevek k poznavanju metuljev (Lepidoptera) Slovenije II: nove vrste metuljčkov (Microlepidoptera)
Authors: Lesar Tone , Habeler Heinz , Arenberger Ernst 
Published: December 2023

The fauna of Lepidoptera of Slovenia is still poorly known, especially the Microlepidoptera group. We present information on 95 Microlepidoptera species new to Slovenia. Records of further 44 species which have been known for Slovenia but without exact information on localities, are also given.
Mating of Myotis capaccinii (Bonaparte, 1827) and other interesting autumn bat observations in the cave Rivčja jama (central Slovenia)
Authors: Mihelič Tina , Zidar Simon 
Published: December 2023

Rivčja jama in central Slovenia is a well researched bat summer roost; however, the autumn composition of its bat fauna is still poorly known. Therefore, we conducted mistnetting in front of the cave on 28. 9. 2011. We caught five bat species; most interesting among them were long-fingered bat (Myotis capaccinii) and lesser mouse-eared bat (M. oxygnathus), both otherwise rarely recorded in central and eastern Slovenia. Mistnets captures, together with visual observation, also confirmed mating of M. capaccinii in the cave.
First records of the European free-tailed bat Tadarida teniotis (Rafinesque, 1814) in Slovenia
Authors: Presetnik Primož , Šalamun Ali 
Published: December 2023

An acoustic survey of bats was conducted throughout 2016 on the slopes of the hill Črna griža near Kozina, and from the end of August 2016 to the end of October 2017 on a small Griško polje plateau close to the village of Dolenja vas near Senožeče — both sites are located in the south-west of Slovenia. Echolocation calls of Tadarida teniotis were recorded at both sites. T. teniotis was recorded near Kozina during 11 nights from April to October 2016, but it was rare, with its 38 passes constituting just 0.53% of all bat passes. It was even rarer near Dolenja vas where it was recorded twice only on the hill Veliki Ognjivec — in April and October 2017 — where constituting only 0.0001% of all bat passes. Both sites are located on the northern border of T. teniotis Submediterranean range. T. teniotis is the 31st bat species recorded in Slovenia and the 30th bat species currently living in the country.
Butterfly diversity (Lepidoptera: Papilionoidea) of Mt. Blegoš and Mt. Koprivnik (Škofjeloško hribovje, Slovenia)
Authors: Šturm Luka , Peternel Andrej , Verovnik Rudi 
Published: December 2023

An overview of the surveys of butterfly fauna of Mt. Blegoš, Mt. Koprivnik and their surroundings is provided. In 2018, 14 surveys were performed and 80 butterfly species on eight transects recorded in the process. Additional surveys in 2019 and 2020 yielded 5 additional butterfly species. Among the butterflies observed, Parnassius mnemosyne, Lycaena hippothoe, Euphydryas maturna, Euphydryas aurinia, Melitaea britomartis, Melitaea diamina, and Pyrgus alveus are identified as vulnerable species, while both Phengaris arion and Phengaris alcon are classified as endangered species in Slovenia. The latter was found on two occasions in July 2018 and July 2020 on a single locality. Eggs of P. alcon were found on the host plant Gentiana cruciata at the same locality. Despite the fact that many species characteristic of higher altitudes were observed, like Aricia artaxerxes, Pyrgus alveus, Erebia stiria and Lasiommata petropolitana, other, which had still been present a few decades ago, were not found (Parnassius apollo and Boloria pales). In this article, the problem of loss of important butterfly habitats in the region due to overgrowing, and the negative impacts of overgrazing is also highlighted.
Sytuacja uchodźców w Libanie oraz ich wpływ na stabilność polityczną państwa
Authors: Spychała-Kij Maria 
Published: December 2023

W październiku 2019 roku, obecne w Libanie niepokoje społeczne zorganizowały się przybierając formę protestów przeciwko rządowi politycznemu. Wciąż nieustające, a wręcz pogłębiające się masowe niepokoje społeczne i nieumiejętność, bądź niemożność udzielenia adekwatnej odpowiedzi ze strony władz politycznych przyczyniły się do umiejscowienia Libanu wśród państw określanych terminem – państwa niestabilnego politycznie. W bazie danych na temat trwających konfliktów – the Center for Preventive Action’s (CPA) Global Conflict Tracker, Liban jest przyporządkowany do kategorii konfliktu o niezmiennym statusie. Od eksplozji w Bejrucie w sierpniu 2020 roku zaczęły pojawiać się propozycje o kolejnej zmianie statusu państwa – z państwa niestabilnego na państwo już upadłe (z ang. failed state).
W kontekście obecnej krytycznej sytuacji społecznej, ekonomicznej oraz politycznej Libanu, jak i poprzedzającej ją długiej historii konfliktów wewnętrznych oraz zewnętrznych, ten artykuł ma na celu przyjrzenie się zjawisku migracji, a dokładniej uchodźctwu, jako jednemu z czynników, który może przyczyniać się do stabilności, jak również niestabilności politycznej państwa. W obliczu specyfiki systemu politycznego Libanu, którego stabilność jest silnie skorelowana z adekwatną reprezentacją poszczególnych sekt religijnych na scenie politycznej, migracja może być uznana jako jeden z determinantów mających wpływ na stabilność państwa, a kwestie z nią związane powinny być brane pod uwagę przy próbach rozwiązania panującego niezadowolenia społecznego oraz stanu niestabilności politycznej.
Synthesis, crystal structure, and Hirschfeld surface analysis of novel ethyl 5-bromo-2-(4-methoxyphenyl) oxazole-4-carboxylate
Authors: Murtuja Sheikh , Jayaprakash Venkatesan , Sinha Barij Nayan 
Published: December 2023

A new oxazole derivative, ethyl 5-bromo-2-(4-methoxyphenyl) oxazole-4-carboxylate, was synthesized and characterized by IR spectroscopy, 13C NMR, Mass spectroscopy, and single-crystal X-ray diffraction analysis. The asymmetric unit of the title compound has two independent molecules (A and B) arranged in an inverted planar orientation, stabilized by intramolecular C-H…O and C-H…N hydrogen bonds and intermolecular C-H…O hydrogen bonds. The crystallographic parameter for the structure C13H12BrNO4 is M =326.15 g/mol, monoclinic, sp. gr. P21/n (no. 14), a = 14.828(2) Å, b = 7.1335(9) Å, c = 25.119(2) Å, β = 100.066(11) °, V = 2616.1(6) Å3, Z = 8. Hirschfeld surface analysis and two-dimensional fingerprint plots provided insight into the short intermolecular interactions, and it was found that H···H (34.4%) interactions contributed the most to the intermolecular interactions. In contrast, the contribution of C · · · C (2.5 %) remained the least among all the interactions.
“That dreadful, loathsome death”: practising hospice narrative doula in China
Authors: Chen Nicole Xuan , Yang Xiaolin 
Published: December 2023

Abstract
Narrative is one of the best intoxicants or tranquilizers for people in pain and in terminal illness. In this article, we explore the role of narrative in hospice doula practice and the important care that the narrative doula can offer to better the experience of death and dying through the theoretical framework of narrative medicine. By sharing our experience of imbuing narrative medicine in hospice care in China, we exemplify how hospice narrative doulas can help people at the end-of-life and their loved ones to fulfil the ritual of their whole-life narrative integration for the purpose of better tackling the challenges brought by imminent death such as the communication breakdown, the disruption of interpersonal narrative connectedness and the feeling of premature grief. Hospice narrative doula thus can help them confront death without innermost pain and achieve a good and dignified death.
The hidden cross talk between bone and tissues through bone turnover
Authors: González-Casaus María Luisa 
Published: December 2023

Abstract
Bone is more than a reservoir of calcium and phosphorus. Its lacuno-canalicular arrangement provides an important pathway for exchange with circulation and currently, the skeleton is considered a large endocrine organ with actions that go beyond the control of calcium-phosphorus balance mediated by fibroblastic growth factor 23 (FGF23). Parallel to the modulating effect of adipokines on bone turnover, certain bone proteins, such as osteocalcin and sclerostin, play a counter-regulatory role on energy metabolism, probably in an attempt to ensure its high energy requirement for bone turnover. In this crosstalk between bone and other tissues, especially with adipose tissue, canonical Wnt/β-catenin signaling is involved and therefore, sclerostin, an osteocyte derived protein that inhibits this signalling, emerges as a potential biomarker. Furthermore, its involvement in diverse pathologic conditions supports sclerostin as a therapeutic target, with an anti-sclerostin antibody recently approved in our country for the treatment of osteoporosis. This review addresses the endocrine nature of bone, the role of osteocalcin, and specially, the regulatory and modulatory role of sclerostin on bone turnover and energy homeostasis through its inhibitory effect on canonical Wnt/β-catenin signaling, as well as its potential utility as a biomarker.
Assessing clinical reasoning skills following a virtual patient dizziness curriculum
Authors: Kotwal Susrutha , Singh Amteshwar , Tackett Sean , Bery Anand K. , Omron Rodney , Gold Daniel , Newman-Toker David E. , Wright Scott M. 
Published: December 2023

Abstract

Objectives
Dizziness is a common medical symptom that is frequently misdiagnosed. While virtual patient (VP) education has been shown to improve diagnostic accuracy for dizziness as assessed by VPs, trainee performance has not been assessed on human subjects. The study aimed to assess whether internal medicine (IM) interns after training on a VP-based dizziness curriculum using a deliberate practice framework would demonstrate improved clinical reasoning when assessed in an objective structured clinical examination (OSCE).

Methods
All available interns volunteered and were randomized 2:1 to intervention (VP education) vs. control (standard clinical teaching) groups. This quasi-experimental study was conducted at one academic medical center from January to May 2021. Both groups completed pre-posttest VP case assessments (scored as correct diagnosis across six VP cases) and participated in an OSCE done 6 weeks later. The OSCEs were recorded and assessed using a rubric that was systematically developed and validated.

Results
Out of 21 available interns, 20 participated. Between intervention (n=13) and control (n=7), mean pretest VP diagnostic accuracy scores did not differ; the posttest VP scores improved for the intervention group (3.5 [SD 1.3] vs. 1.6 [SD 0.8], p=0.007). On the OSCE, the means scores were higher in the intervention (n=11) compared to control group (n=4) for physical exam (8.4 [SD 4.6] vs. 3.9 [SD 4.0], p=0.003) and total rubric score (43.4 [SD 12.2] vs. 32.6 [SD 11.3], p=0.04).

Conclusions
The VP-based dizziness curriculum resulted in improved diagnostic accuracy among IM interns with enhanced physical exam skills retained at 6 weeks post-intervention.
Relektüre ohne Rückkehr
Authors: Melters Benedikt 
Published: December 2023

Abstract
In his last work, Relire le relié, Michel Serres develops a philosophy of religion that circumvents the conventional demarcations of reason and faith, knowledge of the world and knowledge of revelation, or agnosticism and apology. In a structuralistically-informed relecture, he exposes the basic traits of religion. With its narratives and theologoumena, it captures and describes being-in-the-world as an event of universal synthesis. It is – in Serres’ diction – about the basic relatio of energy and information, entropy and negentropy, chaos and order. This relié is described neither as an effort or act of a subject, a system, a language community, nor sufficiently as an emergence effect of evolutionary-natural processes. The recording of this synthesis forbids both any dichotomy of an irresolvable hiatus as well as the construction of a unitary space of any kind.
University researcher-instructor partnership: Co-learning of trans/plurilingual pedagogies for critical language awareness in French L2/Lx classrooms
Authors: Lau Sunny Man Chu , Théberge Sarah , Dault Caroline 
Published: December 2023

Abstract
Drawing on trans/plurilingual approaches, this paper describes a collaborative action research project between an education researcher and two university instructors of French as a second or other language (L2/Lx) in Quebec, Canada to explore holistic and dynamic ways of L2/Lx education for critical language and cultural awareness. Valuing research as praxis, we examine our three-year interdisciplinary collaboration processes, describing how our various research expertise and theoretical orientations as well as our language learning and professional experiences shaped and facilitated our research partnership. Through vignettes from our professional learning community, we each articulate in our own voice the co-learning processes with one another and with students. Using the lenses of co-stance, co-designs, and co-shifts (Tian and Shepard-Carey 2020. (Re)imagining the future of translanguaging pedagogies in TESOL through teacher–researcher collaboration. Tesol Quarterly 54(4). 1131–1143), we captured moments of our emerging nuanced understanding of what and how trans/plurilingual practices supported more in-depth French learning and critical language awareness. As we translanguaged using a mix of English, French, and other languages, we also found ourselves constantly re/trans-languaging our disciplinary expertise and theoretical framings to negotiate our co-stances and practices. Through these transknowledging processes (Heugh 2021. Southern multilingualisms, translanguaging and transknowledging in inclusive and sustainable education. In Philip Harding-Esch & Hywel Coleman (eds.), Language and the sustainable development goals: Selected proceedings of the 12th Language and Development Conference, 37–47. Dakar, Senegal: British Council), we engaged in translingual reflexivity and expanded each other’s fields of vision, supporting more critical reflections and careful listening for transformative change.
Celastrol inhibits angiogenesis and the biological processes of MDA-MB-231 cells via the DEGS1/S1P signaling pathway
Authors: Jia Lulu , Zhu Shengnan , Zhu Mingfei , Nie Rongrong , Huang Lingyue , Xu Siyuan , Luo Yuqin , Su Huazhen , Huang Shaoyuan , Tan Qinyou 
Published: December 2023

Abstract
Celastrol (Cel) shows potent antitumor activity in various experimental models. This study examined the relationship between Cel’s antivascular and antitumor effects and sphingolipids. CCK-8 assay, transwell assay, Matrigel, PCR-array/RT-PCR/western blotting/immunohistochemistry assay, ELISA and HE staining were used to detect cell proliferation, migration and invasion, adhesion and angiogenesis, mRNA and protein expression, S1P production and tumor morphology. The results showed that Cel could inhibit proliferation, migration or invasion, adhesion and angiogenesis of human umbilical vein endothelial cells (HUVECs) and MDA-MB-231 cells by downregulating the expression of degenerative spermatocyte homolog 1 (DEGS1). Transfection experiments showed that downregulation of DEGS1 inhibited the above processes and sphingosine-1-phosphate (S1P) production of HUVECs and MDA-MB-231 cells, while upregulation of DEGS1 had the opposite effects. Coculture experiments showed that HUVECs could promote proliferation, migration and invasion of MDA-MB-231 cells through S1P/sphingosine-1-phosphate receptor (S1PR) signaling pathway, while Cel inhibited these processes in MDA-MB-231 cells induced by HUVECs. Animal experiments showed that Cel could inhibit tumor growth in nude mice. Western blotting, immunohistochemistry and ELISA assay showed that Cel downregulated the expression of DEGS1, CD146, S1PR1-3 and S1P production. These data confirm that DEGS1/S1P signaling pathway may be related to the antivascular and antitumor effects of cel.