bluuebunny/crossref_metadata_2025_split huggingface dataset:
A portrait of the vast polar structure as a young phenomenon: Hints from its member satellites
Authors: Taibi S. , Pawlowski M. S. , Khoperskov S. , Steinmetz M. , Libeskind N. I. 
Published: November 2023

Context. It has been observed that several Milky Way (MW) satellite dwarf galaxies are distributed along a coherent planar distribution known as the vast polar structure (VPOS).
Aims. Here we investigate whether MW satellites located on the VPOS have different physical and orbital properties from those not associated with it.
Methods. Using the proper motion measurements of the MW satellites from the Gaia mission and literature values for their observational parameters, we first discriminate between systems that may or may not be associated with the VPOS, and then compare their chemical and dynamical properties.
Results. Comparing the luminosity distributions of the on-plane and off-plane samples, we find an excess of bright satellites observed on the VPOS. Despite this luminosity gap, we do not observe a significant preference for on-plane or off-plane systems to follow different scaling relations. The on-plane systems also show a striking pattern in their radial velocities and orbital phases: almost all co-orbiting satellites are approaching their pericentre, while both counter-orbiting ones are leaving their last pericentre. This is in contrast to the more random distribution of the off-plane sample. The on-plane systems also tend to have the lowest orbital energies for a given value of angular momentum. These results are robust to the assumed MW potential, even in the case of a potential perturbed by the arrival of a massive Large Magellanic Cloud. Considering them a significant property of the VPOS, we explore several scenarios, all related to the late accretion of satellite systems, which interpret the VPOS as a young structure.
Conclusions. From the results obtained, we hypothesise that the VPOS formed as a result of the accretion of a group of dwarf galaxies. More accurate proper motions and dedicated studies in the context of cosmological simulations are needed to confirm this scenario.
Effects of Resveratrol Co-Administration on Celecoxib Disposition and Pharmacokinetics in Healthy Volunteers
Authors: Helal Nagwa I. , El-Khodary Noha M. , Omran Gamal A. , El-Masry Soha M. 
Published: November 2023

AbstractThe objective of the current study was to investigate the effects of resveratrol (RSV), a natural herbal remedy used as an adjacent anti-inflammatory supplement on, the pharmacokinetics of celecoxib in healthy male volunteers. Twelve healthy human participants were involved in two-period open-labeled trial. Celecoxib (200 mg) was given as a single oral dose under fasting conditions as a control phase. Afterward, RSV (500 mg) commenced as a single oral dose for ten days as a treatment phase. Blood samples were collected during the control and treatment phases and analyzed using the validated High-performance liquid chromatography (HPLC) method. RSV pre-exposure significantly increased the area under the curve (AUC0–24), peak plasma concentration (Cmax), absorption rate constant (ka), and prolongated half-life (t1/2), along with a decrease in elimination rate constant (ke). Meanwhile, the volume of distribution (Vd/F) and apparent total body clearance (CL/F) were significantly decreased for celecoxib. There was no significant change in the time it takes for celecoxib to reach the maximum concentration (tmax) was observed. The obtained results suggested the presence of a beneficial pharmacokinetic interaction between RSV and celecoxib. Consequently, combining resveratrol as an herbal remedy and celecoxib as an anti-inflammatory drug may synergistically reduce inflammation and osteoarthritis with minimal side effects.
Evaluation der psychischen Belastung geburtshilflicher Patientinnen
während des Besuchsverbots der Kliniken im Rahmen der
SARS-CoV-2-Pandemie: Eine prospektive, multizentrische, kontrollierte
Studie
Authors: Geißler Carmen , Knoerlein Julian , Bohlmann Michael K. , Brandt Andreas , Guluzade Durdana , Gerber Monika , Watermann Dirk , Weiz Olga , König Gudrun , Markfeld Filiz , Klar Maximilian , Juhasz-Böss Ingolf , Kunze Mirjam 
Published: November 2023

Zusammenfassung
Einleitung Zu den Risikofaktoren für eine postpartale Depression
zählen fehlende soziale Unterstützung und empfundene soziale
Isolation. Wir möchten ermitteln, ob die Isolation der
stationären Patientinnen auf den Wöchnerinnenstationen im Rahmen
der Corona-Pandemie zu einer erhöhten psychischen Belastung
führt.
Methoden und Durchführung Es handelt sich um eine multizentrische,
kontrollierte Studie geburtshilflicher Patientinnen ab der 35+0
Schwangerschaftswoche, die im Rahmen eines stationären Aufenthaltes
geboren haben. Eingeschlossen wurden Patientinnen während des
Besuchsverbots (Studiengruppe) sowie im Anschluss an das Besuchsverbot
(Kontrollgruppe). Es erfolgte die Erhebung psychischer Belastung durch den
Edinburgh Postnatal Depression Scale (EPDS) während des
stationären Aufenthaltes und sechs bis acht Wochen postpartal.
Ergebnisse Insgesamt konnten 194 Frauen eingeschlossen werden, 107 in die
Studien-, 87 in die Kontrollgruppe. Im Gesamtergebnis des ersten EPDS zeigt sich
ein höherer Score in der Studiengruppe im Vergleich zur Kontrollgruppe
(7,0 vs. 4,9 Punkte).Primipara zeigen einen höheren Score im ersten EPDS
im Vergleich zu Multipara (7,28 vs. 4,82 Punkte).Frauen, die per Sectio caesarea
entbinden, weisen unabhängig von der Isolation einen höheren
Wert im ersten EPDS auf als Frauen, die vaginal entbinden (8,42 vs. 5,11
Punkte). Vergleicht man nur die Frauen, die vaginal entbinden, zeigt sich
weiterhin ein erhöhter EPDS-Score in der Studiengruppe (5,97 vs. 4,07
Punkte).
Schlussfolgerung Im Rahmen der SARS-CoV-2-Pandemie sind Gebärende
und Wöchnerinnen, hierunter vor allem Primipara, erhöhtem
psychischen Stress in den Kliniken ausgesetzt. Die Entbindung per Sectio
caesarea führt zu erhöhter psychischer Belastung
unabhängig vom Besuchsverbot der Kliniken.
Diuretic, Natriuretic, And Ca2+-Sparing Effect Of
The Alkaloid Boldine In Rats
Authors: Steimbach Viviane Miranda Bispo , da Silva Ritade Cássia Vilhena , Mariano Luísa Nathália Bolda , Zanovello Mariana , Macarini Anelise Felício , da Silva Luisa Mota , de Souza Priscila 
Published: November 2023

Abstract
Background Previous studies indicate the renal vasodilating effects of
boldine, an alkaloid found in Peumus boldus. However, its potential to
induce diuresis still needs to be studied.
Methods Wistar rats were used and the urine volume was noted for
8 h and further studied.
Results The acute treatment at 0.1 and 0.3 mg/kg of
boldine showed a diuretic, natriuretic, and Ca2+-sparing
effect in rats without changing the urinary elimination of
K+and Cl-. When boldine was given in combination
with hydrochlorothiazide, there was an increase in urinary volume compared to
the vehicle group. However, this was not different from the treatments in its
isolated form. Urine Ca2+values ​​remained
low but were not enhanced by this association. The excretion of
Na+and Cl- was significantly increased
compared to the group that received only vehicle or boldine. On the other hand,
although the association of amiloride plus boldine did not result in a diuretic
effect, the increase in Na+and the reduction in
K+excretion were significantly potentiated. Furthermore,
in the presence of the non-selective muscarinic receptor antagonist atropine,
boldine showed reduced capacity to increase urinary volume, maintaining the
natriuretic and Ca2+-sparing effect, besides a very evident
K+-sparing action. Similar results were obtained in the
presence of the non-selective cyclooxygenase inhibitor indomethacin.
Furthermore, boldine showed an ex vivo antiurolithiasis activity, reducing
calcium oxalate’s precipitation and crystallization.
Conclusions This study reveals the diuretic, natriuretic,
Ca2+-sparing, and antiurolithiatic effects of boldine, an
action possibly related to muscarinic receptor activation and prostanoid
generation.
Linked-color imaging versus high definition white-light endoscopy for evaluation of post-polypectomy scars of nonpedunculated lesions: LCI-Scar study
Authors: Ortiz Oswaldo , Daca-Alvarez Maria , Rivero-Sánchez Liseth , Saez De Gordoa Karmele , Moreira Rebeca , Cuatrecasas Miriam , Balaguer Francesc , Pellisé Maria 
Published: November 2023

Abstract
Background Detection and treatment of recurrence after piecemeal endoscopic mucosal resection of nonpedunculated colorectal polyps are crucial for avoidance of post-colonoscopy cancer. Linked-color imaging (LCI) has demonstrated improved polyp detection but has never been assessed for evaluation of post-polypectomy scars. Our aim was to compare sensitivity and negative predictive value (NPV) between LCI and white-light endoscopy (WLE) for detection of post-polypectomy recurrence.
Methods Patients undergoing surveillance colonoscopy after resection of lesions ≥15 mm were included in this prospective, single-center, randomized, crossover study. Each post-polypectomy scar underwent two examinations, one with LCI and the other with WLE, performed by two blinded endoscopists. Blue-light imaging (BLI) was then applied. A diagnosis of recurrence with a level of confidence was made for each modality and histopathology was the gold standard.
Results 129 patients with 173 scars were included. Baseline patient, lesion, and procedural characteristics were similar in both arms. Recurrence was detected in 56/173 (32.4%), with 27/56 (48.2%) adenomas and 29/56 (51.8%) serrated lesions. LCI had greater sensitivity (96.4% [95%CI 87.8%–99.5%]) versus WLE (89.3% [95%CI 78.1%–95.9%]) and greater NPV (98.1% [95%CI 93.4%–99.8%] versus 94.6% [95%CI 88.7%–98.0%]). Paired concordance between modalities was 96.0%. In discordant cases, LCI identified four true-positive cases not detected by WLE and reclassified one false-positive of WLE. WLE reclassified two false positives of LCI without any increase in recurrence detection.
Conclusions LCI was highly accurate and had greater ability than WLE to rule out recurrence on post-polypectomy scars after resection of large polyps.
Endoscopic ultrasound-guided ethanol ablation versus surgical resection of insulinomas
Authors: Jürgensen Christian , Eckart Marius , Haberbosch Linus , Tacke Frank , Sandforth Arvid , Birkenfeld Andreas L. , Overkamp Dietrich , Daniels Martin , Mogl Martina , Goretzki Peter , Strasburger Christian , Mai Knut , Spranger Joachim , Jumpertz von Schwartzenberg Reiner 
Published: November 2023

Abstract
Purpose Insulinoma is a rare tumor of the pancreas that can lead to hypoglycemia. To date, the standard therapy is surgical resection. After the first case report of successful endoscopic ultrasound-guided (EUS) ethanol injection 16 years ago, the need for establishing an alternative treatment method remains unchanged given the high morbidity rates of surgery and its unsuitability in some patients.
Materials and Methods Here, we provide retrospective data from 33 insulinoma patients that were treated at our center between 2010 and 2021. Of these, 9 patients were treated with EUS-guided ethanol injection and 24 underwent pancreatic surgery.
Results The ethanol group was older (ethanol: mean ± SE 67.8±11.2 years vs. surgery: 52.3±15.7, p=0.014) with a higher Charlson Comorbidity Index (3.0 (1.0;4.0) vs. 1.0 (0.0;2.0), p=0.008). The lowest glucose values were similar between groups before (ethanol: 2.09±0.17 mmol/l vs. surgery: 1.81±0.08, p=0.158) and after (4.95±0.74 vs. 5.41±0.28, p=0.581) the respective treatments. Complications occurred more frequently in the surgery group (11 % vs. 54 %, p=0.026). One patient after prior partial pancreatectomy died postoperatively. The hospitalization time was significantly shorter in the ethanol group (4.78±0.78 days vs. 19.88±4.07, p<0.001).
Conclusion EUS-guided ethanol injection can be similarly effective for the treatment of hyperinsulinemic hypoglycemia compared with pancreatic surgery but seems to be associated with less severe complications. This implies the need for prospective randomized trials in insulinoma patients with a low risk for malignancy.
Intraductal radiofrequency ablation plus biliary stent versus stent alone for malignant biliary obstruction: a systematic review and meta-analysis
Authors: de Oliveira Veras Matheus , de Moura Diogo Turiani Hourneaux , McCarty Thomas R. , de Oliveira Guilherme Henrique Peixoto , Gomes Rômulo Sérgio Araújo , Landim Davi Lucena , Nunes Felipe Giacobo , Franzini Tomazo Antônio Prince , Lera dos Santos Marcos Eduardo , Bernardo Wanderley Marques , de Moura Eduardo Guimarães Hourneaux 
Published: November 2023

Abstract
Background and study aims Recurrent biliary stent occlusion and tumor ingrowth remain a major concern among patients with malignant biliary obstruction (MBO) with significant impact on patient morbidity and survival. Intraductal radiofrequency ablation (RFA) has emerged as a promising treatment that seeks to extend stent patency. This study aimed to evaluate the impact of RFA on overall survival (OS) and stent patency among patients with unresectable MBO.
Methods A comprehensive search of electronic databases was performed for randomized controlled trials (RCTs) comparing RFA plus biliary stent (RFA+S) versus biliary stent alone (S-alone). Outcomes assessed included overall survival, stent patency, and adverse events (AEs) with mean difference (MD) calculated from pooled proportions. Subgroup analyses were performed for hilar strictures and cholangiocarcinoma (CCA).
Results Six RCTs (n=481 patients) were included and demonstrated
improved survival among patients who received RFA+S (MD 85.70 days , 95% confidence interval
[CI] 34.29–137.10; I2=98%; P =0.001). The pooled MD for
total stent patency was 22.25 days (95% CI –17.38–61.87; I2=97%; P=0.27). There was no difference in AEs between RFA+S vs S-alone (P >0.05). On subgroup analyses, RFA+S was associated with improved
stent patency (MD 79.25 days; 95% CI 50.77–107.73; I2=59%; P <0.00001) and OS (MD 83.14 (95% CI 29.52–136.77; I2=97%; P <0.01] for CCA. For hilar strictures, stent patency was improved
among patients with RFA+S [MD 83.71 days (95% CI 24.85–142.56; I2=84%; P <0.01].
Conclusions RFA+S improved OS in the treatment of MBO when compared with S-alone. Moreover, the RFA therapy prolonged stent patency in hilar strictures and CCA, with similar rates of AEs.
Endoscopic, “Scarless” Composite Flap Face and Neck Lift
Authors: Mani Marc 
Published: November 2023

AbstractDeep-plane or composite flap facelift techniques allow deep structural rejuvenation of the face by release of retaining ligaments in the subsuperficial musculoaponeurotic system (sub-SMAS) plane with elevation and fixation of the SMAS/platysma/skin flap as a single, “en bloc” unit. This means that in the cases with mild to moderate skin laxity, the preauricular incision serves the purpose of access only. The author therefore developed an endoscopic-assisted, en bloc composite flap face and neck lift without a preauricular incision. The technique uses the prezygomatic and premasseteric (facial) and subplatysmal (neck) spaces as ideal optical cavities for endoscopic dissection and ligament release. Verticalization of fixation vectors and modified concho-mastoid traction sutures are used to minimize preauricular skin redundancy. The surgical procedure is described in detail. Clinical experience in 41 consecutive cases and comparison to other techniques with respect to relevant anatomy are also presented. This endoscopic en bloc composite flap facelift technique consistently and safely produced results comparable to conventional, “open” composite flap facelifts done by the same surgeon on similar candidates during a prior period.
A Practical Guide to Sigma-1 Receptor Positron Emission Tomography/Magnetic Resonance Imaging: A New Clinical Molecular Imaging Method to Identify Peripheral Pain Generators in Patients with Chronic Pain
Authors: Shen Bin , Yoon Daehyun , Castillo Jessa , Biswal Sandip 
Published: November 2023

AbstractAccurately identifying the peripheral pain generator in patients with chronic pain remains a major challenge for modern medicine. Millions of patients around the world suffer endlessly from difficult-to-manage debilitating pain because of very limited diagnostic tests and a paucity of pain therapies. To help these patients, we have developed a novel clinical molecular imaging approach, and, in its early stages, it has been shown to accurately identify the exact site of pain generation using an imaging biomarker for the sigma-1 receptor and positron emission tomography/magnetic resonance imaging. We hope the description of the work in this article can help others begin their own pain imaging programs at their respective institutions.
Fast electron damage mechanism of epoxy resin studied by electron energy loss spectroscopy and electron diffraction
Authors: Kikkawa Jun , Nii Aoi , Sakaniwa Yoshiaki , Kon Naochika , Sakamaki Marina , Ohashi Touyou , Nita Nobuyasu , Harano Koji , Kimoto Koji 
Published: November 2023

The damage mechanism and exposure tolerance of epoxy resins to fast electrons remain unclear. We quantitatively investigated the effects of electron irradiation on a common epoxy resin by dose-dependent electron energy loss spectroscopy. The results show that sp3 states of nitrogen, oxygen, and their adjacent carbon atoms were converted to sp2 states, forming imine (C=N) and carbonyl (C=O) as the total electron dose increased. The sp3 to sp2 conversion mechanism was proposed. The epoxy resin was very sensitive to fast electrons and the original electronic states were maintained up to a total dose of ∼103e− nm−2 at a low temperature of 103 K. Dose-dependent electron diffraction revealed that the intra- and intermolecular geometries changed below and around the total dose of ∼103e− nm−2.
Analytic Hall magnetohydrodynamics toroidal equilibria via the energy-Casimir variational principle
Authors: Giannis A , Kaltsas D A , Throumoulopoulos G N 
Published: November 2023

Abstract
Equilibrium equations for magnetically confined, axisymmetric plasmas are derived by means of the energy-Casimir variational principle in the context of Hall magnetohydrodynamics (MHD). This approach stems from the noncanonical Hamiltonian structure of Hall MHD, the simplest, quasineutral two-fluid model that incorporates contributions due to ion Hall drifts. The axisymmetric Casimir invariants are used, along with the Hamiltonian functional to apply the energy-Casimir variational principle for axisymmetric two-fluid plasmas with incompressible ion flows. This results in a system of equations of the Grad–Shafranov–Bernoulli (GSB) type with four free functions. Two families of analytic solutions to the GSB system are then calculated, based on specific choices for the free functions. These solutions are subsequently applied to Tokamak-relevant configurations using proper boundary shaping methods. The Hall MHD model predicts a departure of the ion velocity surfaces from the magnetic surfaces which are frozen in the electron fluid. This separation of the characteristic surfaces is corroborated by the analytic solutions calculated in this study. The equilibria constructed by these solutions exhibit favorable characteristics for plasma confinement, for example they possess closed and nested magnetic and flow surfaces with pressure profiles peaked at the plasma core. The relevance of these solutions to laboratory and astrophysical plasmas is finally discussed, with particular focus on systems that involve length scales on the order of the ion skin depth.
A discrete discontinuity between the two phases of gravity
Authors: Sengupta Sandipan 
Published: November 2023

Abstract
When tetrad (metric) fields are not invertible, the standard canonical formulation of
gravity cannot be adopted as it is. Here we develop a Hamiltonian theory of gravity for
noninvertible tetrad. In contrast to Einstein gravity, this phase is found to exhibit three
local degrees of freedom. This reflects a discrete discontinuity in the limit of a vanishing
tetrad determinant. For the particular case of vanishing lapse, the Hamiltonian constraint
disappears from the classical theory upon fixing the torsional gauge-freedom. Any state
functional invariant under the internal gauge rotations and spatial diffeomorphisms is a formal solution of the associated quantum theory. The formulation here provides a Hamiltonian
basis to analyze gravity theory around a physical singularity, which corresponds to a zero of
the tetrad determinant in curved spacetime.
Evaluation of long-term robustness of the International System of Reference (SIR) used in radionuclide metrology based on the meta-analysis of its machine-readable database
Authors: Coulon Romain , Michotte Carine , Gressier Vincent 
Published: November 2023

Abstract
In support of the CIPM MRA, the reference system in radionuclide metrology (SIR) is a unique experimental facility that has been able to provide continuous key comparison results for 72 radionuclides for 46 years. These measurement data are now available in a machine-readable format, which allows statistical analysis of these measurement results to be performed efficiently. Such a meta-analysis was conducted to verify whether or not the accumulated data confirmed the bold assumption made in the 1970s of the long-term robustness of the system over decades of operation. It was notably assumed that variation in the properties of the standard solution to be measured or the choice of the 226Ra reference source would have no impact on the measurement. For the majority of radionuclides measured by the SIR, the non-parametric significance tests of the null hypothesis carried out in this study gave no evidence, at the 95% confidence level, that the above statement should be reconsidered. However, this meta-analysis revealed a significant impact of solution density in the case of 109Cd, corroborating previous observations made in the case of 241Am where the robustness of an ionization chamber with respect to the density variation of the solution does not appear to be perfect. The extension of the SIR by a liquid scintillation system is under development. It will improve the robustness of international comparison results for those borderline cases where radionuclides emit only low-energy x-rays or gamma rays (<100 keV).
Interaction between COLREG-compliant collision avoidance systems in a multiple MASS scenario
Authors: Zaccone R , Martelli M 
Published: November 2023

Abstract
The transportation systems are heading towards increasing autonomy in all domains, and the maritime field makes no exception. The International Maritime Organization has been working on releasing a regulatory framework for Maritime Autonomous Surface Ships (MASS) to keep pace with the technological developments in the field. Autonomous shipping forces the researcher and the designers to face a wide range of scientific challenges, such as navigation decision support systems, collision avoidance algorithms, path planning, navigation and control, sensor data processing and fusion, remote control, and communication, with the final intent of achieving a fully integrated and autonomous worldwide maritime transportation system, where a human-less collaborative conflict resolution could potentially retire the COLREGs. However, the maritime sector will first face a transition period where traditional ships will share the seas and interact with heterogeneous MASS with various autonomous capabilities featuring different and probably incompatible communication protocols. In such a scenario, the COLREGs will still play a primary role in helping the collision avoidance systems resolve conflicts and limiting the degrees of freedom. This paper aims to study the interaction among multiple vessels with autonomous collision avoidance capabilities operating in a close navigation scenario. The ships operate according to a COLREG-compliant collision avoidance algorithm. The paper relies on numerical simulation to systematically investigate different scenarios in which autonomous vessels operate and interact in the presence of fixed obstacles. Results are presented and critically discussed.