bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peningkatan Kapasitas Produksi Bumbu Bali “Nepaon” Suka Wirang Desa Buki
Authors: Suniantara I Ketut Putu , Suwardika Gede , Sopandi Agus Tatang , Masakazu Kadek , Wijaya I Gusti Ngurah Satria 
Published: November 2023

The Balinese spice "NePaon" is produced by the Suka Wirang group which is in Bukit Tibulaka Village. The main problems faced by partners are (1) in the production sector, production capacity is less than optimal and packaging leaks, causing labels to become damaged. (2) in the marketing sector, there are limitations to marketing carried out conventionally. The final problem (3) is in the legal sector, where the partner product does not yet have a production permit as a legality and security aspect in expanding marketing. The solution to the problem provided is by offering donations for production equipment and some training. The method of implementing the service is by adopting the PALS (participatory learning system) method. The results of the service obtained are an increase in production capacity in the last two months, increased knowledge of partners in packaging with new designs. Partners already have social media as digital marketing. Partners have knowledge in certification and electronic transactions. Partner responses to the implementation of activities with results were 31% satisfactory and 69% very satisfactory. Meanwhile, in training, partner responses were 37.5% satisfactory and 62.5% very satisfactory. Keywords: Balinese spices; PALS; production training; increased production Abstrak: Bumbu Bali “NePaon” di produksi oleh kelompok Suka Wirang yang terletak di Desa Bukit Tibulaka. Permasalahan utama yang dihadapi mitra yaitu (1) bidang produksi, kapasitas produksi kurang maksimal dan pengemasan mengalami kebocoran sehingga menyebabkan label menjadi rusak. (2) bidang pemasaran, adanya keterbatasan pemasaran yang dilakukan secara konvesional. Permasalahan terakhir (3) bidang hukum, dimana produk mitra belum memiliki izin produksi sebagai aspek legalitas dan standar keamanan dalam memperluas pemasaran. Pemecahan masalah yang diberikan yaitu dengan menawarkan sumbangan alat – alat produksi dan beberapa pelatihan. Metode pelakasanaan pengabdian dengan mengadopsi metode PALS (participatory learning system). Hasil pengabdian diperoleh yaitu adanya peningkatan kapasitas produksi dalam dua bulan terakhir, meningkatnya pengetahuan mitra dalam melakukan pengemasan dengan desain yang baru. Mitra sudah memiliki media sosial sebagai pemasaran digital marketing. Mitra memiliki pengatahuan dalam sertifikasi dan transaksi elektronik. Respon mitra terhadap pelaksanaan kegiatan dengan hasil 31% memuaskan dan 69% sangat memuaskan. Sedangkan pada pelatihan, respon mitra 37,5% memuaskan dan 62,5% sangat memuaskan.Kata kunci: bumbu bali; PALS; pelatihan produksi; peningkatan produksi
UPAYA PENINGKATAN PENGETAHUAN IBU HAMIL TENTANG PENGGUNAAN AROMATHERAPY UNTUK MENGURANGI NYERI PERSALINAN
Authors: Yunika Regina Pricilia , Yadul Ulya Yadul Ulya , Siskha Maya Herlina3 Siskha Maya Herlina 
Published: November 2023

Persalinan adalah proses pengeluaran janin yang terjadi pada kehamilan cukup bulan lahir spontan dengan presentasi belakang kepala tanpa komplikasi pada ibu dan janin. Saat melahirkan, ibu merasakan nyeri yang dapat menggangu kenyamanan pada saat terjadinya kontraksi. Nyeri persalinan muncul pada kala I fase aktif. Metode untuk mengurangi nyeri dampak persalinan dapat dilakukan dengan metode farmakologis dan non farmakologis. Penanganan non farmakologis pada nyeri persalinan dapat ditangani dengan aromaterapi karena dipercaya sebagai terapi komplementer untuk menurunkan intensitas nyeri, yaitu dengan minyak esensial yang berasal dari bau harum tumbuhan untuk mengurangi masalah kesehatan, bau yang berpengaruh terhadap otak yang menenangkan pada saat persalinan. Tujuan: untuk meningkatkan pengetahuan ibu hamil tentang penggunaan aromatherapy untuk mengurangi nyeri persalinan. Metode: penyuluhan, diskusi, tanya jawab, serta pretest dan posttest yang dilaksanakan di Desa Geguntur, Kelurahan Jempong Baru, Kecamatan Sekarbela, Kota Mataram pada tanggal 8 Agustus 2023. Hasil: terjadi peningkatan pengetahuan ibu hamil yang mempunyai pengetahuan baik sebesar 30,8%, yaitu dari 61,5% meningkat menjadi 92,3%. Kesimpulan: terdapat peningkatan pengetahuan ibu hamil tentang penggunaan aromatherapy untuk mengurangi nyeri persalinan setelah mendapatkan penyuluhan kesehatan.
PENGARUH CURRENT RATIO, DEBT TO EQUITY RATIO DAN TOTAL ASSET TURNOVER TERHADAP RETURN ON ASSET STUDI PADA PT. INDOFARMA Tbk YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2015-2019
Authors: Junaedi Junaedi 
Published: November 2023

PT. Indofarma Tbk merupakan perusahaan yang bergerak dibidang industri farmasi dan alat kesehatan. Dengan perkembangan yang sangat pesat, mengharuskan perusahaan mampu mengatur keuangan secara produktif dari berbagai komponen didalamnya. Bahan pertimbangan atas kinerja perusahaan dalam memperoleh tujuannya yakni mendapatkan keuntungan secara maksimal dan membangun citra yang baik. Tujuan penelitian ini yakni untuk mengetahui pengaruh current ratio, debt to equity ratio dan total asset turnover terhadap return on asset pada PT. Indofarma Tbk periode 2015-2019. Metodologi penelitian yang digunakan yakni metode asosiatif. Jenis Data yang digunakan adalah data time series, Dimana datanya diperoleh dari annual report PT. Indofarma Tbk periode 2015-2019. Teknik analisis data yang digunakan yakni analisis deksriptif menggunakan rumus masing-masing variabel, analisis regresi berganda, analisis determinasi, serta uji hipotesis. Berdasarkan hasil penelitian, menunjukkan bahwa tidak terdapat pengaruh secara simultan dan signifikan current ratio, debt to equity ratio dan total asset turnover terhadap return on asset,. Atas hal tersebut saran yang diberikan yakni, perusahaan perlu memperhatikan serta mengatur setiap komponen yang terdapat dalam keuangan, karena menjadi bagian yang terpenting dalam perolehan keuntungan serta kinerja perusahaan yakni PT. Indofarma Tbk.
PENGARUH KUALITAS PELAYANAN, PRODUK SERTA HARGA TERHADAP KEPUASAN PELANGGAN PADA PT. FIRST MEDIA KARAWACI TANGERANG
Authors: Utami Wanda Yulia , Nadhifah Rifka 
Published: November 2023

Abstrak
Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh variabel (X1) yaitu kualitas pelayanan terhadap variabel (Y) yaitu kepuasan pelanggan, pengaruh variabel (X2) yaitu produk terhadap variabel (Y) yaitu kepuasan pelanggan, dan pengaruh variabel (X3) terhadap variabel (Y) kepuasan pelanggan. Penelitian ini dilakukan dengan menggunakan metode survey. Populasi dalam penelitian ini adalah konsumen PT First Media Karawaci Tangerang. Pengambilan sampel dengan jumlah 84 orang responden dilakukan dengan teknik incidental sampling. Sedangkan analisis dilakukan dat dengan, uji hipotesis, uji validitas, uji reliabilitas, analisis regresi sederhana, analisis regresi berganda, analisis korelasi sederhana, analisis korelasi berganda dan analisis koefisien determinasi (R2). Berdasarkan perhitungan secara parsial yaitu pengaruh Berdasarkan hasil penelitian bahwa adanya pengaruh yang positif dan signifikan antara Kualitas Pelayanan (X1) terhadap Kepuasan Pelanggan (Y) pada Pada PT First Media Karawaci Tangerang Dibuktikan dengan hasil uji t yang mempunyai nilai thitung 15,530 maka diperoleh ttabel = yaitu 1,990. Dikarenakan thitung>ttabel yaitu 15,530>1,990 maka Ha diterima dan Ho ditolak artinya terdapat pengaruh yang positif dan signifikan antara Kualitas Pelayanan terhadap Kepuasan Pelanggan. Produk (X2) terhadap Kepuasan Pelanggan (Y) pada Pada PT First Media Karawaci Tangerang Dibuktikan dengan hasil uji t yang mempunyai nilai thitung 8,810 maka diperoleh ttabel = yaitu 1,990. Dikarenakan thitung>ttabel yaitu 8,810>1,990 maka Ha diterima dan Ho ditolak artinya terdapat pengaruh yang positif dan signifikan antara Produk terhadap Kepuasan Pelanggan. Harga (X3) terhadap Kepuasan Pelanggan pada PT. First Media Karawaci Tangerang dibuktikan dengan hasil uji t yang mempunyai nilai thitung 4,369 maka diperoleh ttabel=1,990. Dikarenakan thitung>ttabel yaitu 4,369>1,990 maka Ha diterima dan Ho ditolak artinya terdapat pengaruh yang positif dan signifikan antara Harga dengan Kepuasan Pelanggan. Berdasarkan hasil perhitungan, diperoleh nilai Fhitung =117,390, maka diperoleh Ftabel =2,72. Dengan demikian hasil perbandingannya adalah (117,390>2,72). Maka Ha diterima dan Ho ditolak artinya terdapat pengaruh yang positif dan signifikan antara Kualitas Pelayanan, Produk dan Harga Terhadap Kepuasan Pelanggan.
Retrospective Analysis of Allergen Distribution Dynamics in Central Taiwan
Authors: Tseng Yu-Wei , Er Tze-Kiong 
Published: November 2023

Introduction: Allergy is a type Ⅰ hypersensitivity reaction to certain substances (allergens) such as environmental factors, food and drugs. Allergies are a significant public health issue, and therefore, understanding the distribution patterns of allergens in specific regions is important. This study aimed to retrospectively analyse allergen distribution patterns in Central Taiwan over a 5 years period (2018–2022).Methods: Data of patients who had allergen sensitization testing using the OPTIGEN® Allergen-Specific IgE Assay from the 1st of January 2018 to the 31st of December 2022 were reviewed retrospectively. Statistical analyses were performed to determine the prevalence and distribution of allergens in our study population.Results: A total of 8,444 patients (3,784 males and 4,660 females) who attended the Asia University Hospital for allergen detection were enrolled in this study. Dermatophagoides farina (41.8%), Dermatophagoides pteronyssinus (37.9%), house dust (24.6%), cockroach mix (17.7%), crab (12.6%), clam (9.8%), shrimp (9.1%), cat dander (8.1%), pig weed (8%) and peanut (7.8%) were identified as the ten allergens that most commonly induced sensitization in our study population. Additionally, crab, clam, shrimp, peanut and beef were the five most common food allergens.Conclusion: In summary, our findings contribute significantly to the knowledge on allergen distribution in Central Taiwan. Our identification of prevalent allergens may contribute to an improved understanding of the epidemiology of allergies in this region.
Linking soil adsorption-desorption characteristics with grain zinc concentrations and uptake by teff, wheat and maize in different landscape positions in Ethiopia
Authors: Desta Mesfin K. , Broadley Martin R. , McGrath Steve P. , Hernandez-Allica Javier , Hassall Kirsty L. , Gameda Samuel , Amede Tilahun , Haefele Stephan M. 
Published: November 2023

AimZinc deficiencies are widespread in many soils, limiting crop growth and contributing to Zn deficiencies in human diets. This study aimed at understanding soil factors influencing grain Zn concentrations and uptake of crops grown in different landscape positions in West Amhara, Ethiopia.MethodsOn-farm experiments were conducted in three landscape positions, with five farmers’ fields as replicates in each landscape position, and at three sites. Available Zn from the soil (Mehlich 3, M3, Zn) and applied fertilizer (NET_FERT Zn, estimated based on adsorption/desorption characteristics and applied Zn) were related to the actual grain Zn concentration and uptake of teff, wheat, and maize. Zinc fertilizer treatments tested were Zn applied at planting (basal), basal plus side dressing and a control with no Zn applied.ResultsZn treatments had a significant effect on grain Zn concentration (increase by up to 10%) but the effect on grain yield was variable. Differences in crop Zn concentrations along the landscape positions were observed but not at all sites and crops. Trial results showed that soils with higher soil pH and Soil Organic Carbon (SOC) (typical of footslope landscape positions) tended to adsorb more applied Zn (reduce NET_FERT Zn) than soils with lower soil pH and SOC (typical of upslope landscape positions). Zn availability indicators (M3, NET_FERT Zn, clay%) explained 14-52% of the observed variation in grain Zn concentrations, whereas macronutrient indicators (Total N, exchangeable K) together with M3 Zn were better in predicting grain Zn uptake (16 to 32% explained variability). Maize had the lowest grain Zn concentrations but the highest grain Zn uptake due to high yields.ConclusionWe found that the sum of indigenous and fertilizer Zn significantly affects grain Zn loadings of cereals and that the associated soil parameters differ between and within landscape positions. Therefore, knowledge of soil properties and crop characteristics helps to understand where agronomic biofortification can be effective.
Implementation of the multielectrode radiofrequency-balloon in real-world clinical practice—operator learning curve and procedural outcome at a high-volume center
Authors: Zylla Maura M. , Starrach Lydia , Rahm Ann-Kathrin , Thomas Dierk , Frey Norbert , Lugenbiel Patrick 
Published: November 2023

BackgroundThe novel multielectrode radiofrequency (RF) balloon catheter (HELIOSTAR™. Biosense Webster) is a new technology for pulmonary vein isolation (PVI) in atrial fibrillation (AF), combining RF-ablation and 3D-mapping visualization with the concept of a “single-shot”-ablation device. This study evaluates the operator learning curve und procedural outcome during implementation of the multielectrode RF-balloon at a high-volume center.MethodsThe first 40 patients undergoing PVI by multielectrode RF-balloon catheter at Heidelberg University Hospital were included in this prospective study. Procedural outcome was analyzed over the course of increasing experience with the device.Results157/157 pulmonary veins (PVs) were successfully isolated with the RF-balloon catheter, in 73.2% by a single RF-application. Median time to isolation (TTI) was 11.0 s (Q1 = 8.0 s; Q3 = 13.8 s). Median procedure time was 62.5 min (Q1 = 50.0 min; Q3 = 70.5 min). LA-dwell time was 28.5 min (Q1 = 23.3 min; Q3 = 36.5 min). Median fluoroscopy duration was 11.6 min (Q1 = 10.1 min; Q3 = 13.7 min). No serious procedure-related complications were observed, apart from one case of unclear, post-procedural acute-on-chronic kidney injury. With increasing operator experience, an additional reduction in procedure duration was observed.ConclusionRapid implementation of a “single shot”-ablation device combining RF-ablation and 3D-mapping can be achieved with high acute procedural efficacy and safety at a high-volume center. Previous experience with “single-shot” ablation devices may be advantageous for time-efficient introduction of the novel RF-balloon catheter into clinical practice.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT05603611.
Effect of different exercise regimens on LVEF and restenosis incidence in patients after PCI: a network meta-analysis and an overview of systematic reviews
Authors: Li Hongpeng , Lu Li , Han Zhongyu , Liu Zhixiang , Pan Juanhong , Wang Yongsheng , Gao Xiuhua , Cai Yijin , Zhao Tianyu , Nie Qian , Zhang Hongcai , Zhang Di , Jin Song 
Published: November 2023

ObjectiveWe aimed to evaluate the effects of different exercise rehabilitation (ER) programs on LVEF and the incidence of restenosis in patients after percutaneous coronary intervention (PCI) through a systematic review and an integrated network meta-analysis (NMA) to provide a reference for the clinical formulation of ER programs for PCI patients.MethodsMeta-analyses of the effects of different types of ER programs on LVEF and the incidence of reinfarction in post-PCI patients were retrieved from 11 domestic and foreign databases. The methodological and reporting quality of the included systematic reviews were evaluated using the AMSTAR 2 and PRISMA statements. The GRADE scoring system was used to evaluate the quality of evidence found in the studies included in the meta-analysis, and studies with high and intermediate-quality evidence were qualitatively analyzed. Stata software (version 16.0) was used to conduct an integrated NMA of the original RCTs with moderate and low risk of bias.ResultSixteen meta-analyses were included in this evaluation. The reporting quality of the included meta-analyses was relatively complete, and the methodological quality was low. Seventy RCTs were included in the NMA. The results showed that all types of rehabilitative exercises were safe and effectively increased LVEF and reduced the incidence of coronary restenosis in patients. The comprehensive exercise program was the most likely to improve LVEF, and the comprehensive exercise program, early exercise program, and high-intensity interval exercise were better than aerobic exercise. Comprehensive exercise programs, early exercise programs, and aerobic exercise reduced the incidence of restenosis in patients. However, Chinese Qigong did not reduce the incidence of restenosis in patients, and there was a risk of bias and inconsistency in the quantitative analysis of restenosis incidence.ConclusionComprehensive exercise programs have the greatest therapeutic significance in improving cardiac output and reducing restenosis rates in post-PCI patients. The early exercise program has great potential but requires kinesiologists to work with physicians to structure the program and strengthen out-of-hospital management. Aerobic exercise has the least therapeutic significance, and Chinese Qigong is suitable for promotion based on its better efficacy than aerobic exercise and may be an alternative to aerobic exercise, but more experimental evidence is needed.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, PROSPERO CRD42022374590.
Long-term green-Mediterranean diet may favor fasting morning cortisol stress hormone; the DIRECT-PLUS clinical trial
Authors: Alufer Liav , Tsaban Gal , Rinott Ehud , Kaplan Alon , Meir Anat Yaskolka , Zelicha Hila , Ceglarek Uta , Isermann Berend , Blüher Matthias , Stumvoll Michael , Stampfer Meir J. , Shai Iris 
Published: November 2023

BackgroundFasting morning cortisol (FMC) stress hormone levels, are suggested to reflect increased cardiometabolic risk. Acute response to weight loss diet could elevate FMC. Richer Polyphenols and lower carbohydrates diets could favor FMC levels. We aimed to explore the effect of long-term high polyphenol Mediterranean diet (green-MED) on FMC and its relation to metabolic health.MethodsWe randomized 294 participants into one of three dietary interventions for 18-months: healthy dietary guidelines (HDG), Mediterranean (MED) diet, and Green-MED diet. Both MED diets were similarly hypocaloric and lower in carbohydrates and included walnuts (28 g/day). The high-polyphenols/low-meat Green-MED group further included green tea (3-4 cups/day) and a Wolffia-globosa Mankai plant 1-cup green shakeFMC was obtained between 07:00-07:30AM at baseline, six, and eighteen-months.ResultsParticipants (age=51.1years, 88% men) had a mean BMI of 31.3kg/m2, FMC=304.07nmol\L, and glycated-hemoglobin-A1c (HbA1c)=5.5%; 11% had type 2 diabetes and 38% were prediabetes. Baseline FMC was higher among men (308.6 ± 90.05nmol\L) than women (269.6± 83.9nmol\L;p=0.02). Higher baseline FMC was directly associated with age, dysglycemia, MRI-assessed visceral adiposity, fasting plasma glucose (FPG), high-sensitivity C-reactive-protein (hsCRP), testosterone, Progesterone and TSH levels (p ≤ 0.05 for all). The 18-month retention was 89%. After 6 months, there were no significant changes in FMC among all intervention groups. However, after 18-months, both MED groups significantly reduced FMC (MED=-1.6%[-21.45 nmol/L]; Green-MED=-1.8%[-26.67 nmol/L]; p&lt;0.05 vs. baseline), as opposed to HDG dieters (+4%[-12 nmol/L], p=0.28 vs. baseline), whereas Green-MED diet FMC change was significant as compared to HDG diet group (p=0.048 multivariable models). Overall, 18-month decrease in FMC levels was associated with favorable changes in FPG, HbA1c, hsCRP, TSH, testosterone and MRI-assessed hepatosteatosis, and with unfavorable changes of HDLc (p&lt;0.05 for all, weight loss adjusted, multivariable models).ConclusionLong-term adherence to MED diets, and mainly green-MED/high polyphenols diet, may lower FMC, stress hormone, levels,. Lifestyle-induced FMC decrease may have potential benefits related to cardiometabolic health, irrespective of weight loss.Clinical trial registrationClinicalTrials.gov, identifier NCT03020186.
The predictive significance of lipid accumulation products for future diabetes in a non-diabetic population from a gender perspective: an analysis using time-dependent receiver operating characteristics
Authors: Qiu Jiajun , Kuang Maobin , Zou Yang , Yang Ruijuan , Shangguan Qing , Liu Dingyang , Sheng Guotai , Wang Wei 
Published: November 2023

ObjectiveThe increasing prevalence of diabetes is strongly associated with visceral adipose tissue (VAT), and gender differences in VAT remarkably affect the risk of developing diabetes. This study aimed to assess the predictive significance of lipid accumulation products (LAP) for the future onset of diabetes from a gender perspective.MethodsA total of 8,430 male and 7,034 female non-diabetic participants in the NAGALA (NAfld in the Gifu Area, Longitudinal Analysis) program were included. The ability of LAP to assess the risk of future new-onset diabetes in both genders was analyzed using multivariate Cox regression. Subgroup analysis was conducted to explore the impact of potential modifiers on the association between LAP and diabetes. Additionally, time-dependent receiver operator characteristics (ROC) curves were used to assess the predictive power of LAP in both genders for new-onset diabetes over the next 2-12 years.ResultsOver an average follow-up of 6.13 years (maximum 13.14 years), 373 participants developed diabetes. Multivariate Cox regression analysis showed a significant gender difference in the association between LAP and future diabetes risk (P-interaction&lt;0.05): the risk of diabetes associated with LAP was greater in females than males [hazard ratios (HRs) per standard deviation (SD) increase: male 1.20 (1.10, 1.30) vs female 1.35 (1.11, 1.64)]. Subgroup analysis revealed no significant modifying effect of factors such as age, body mass index (BMI), smoking history, drinking history, exercise habits, and fatty liver on the risk of diabetes associated with LAP (All P-interaction &lt;0.05). Time-dependent ROC analysis showed that LAP had greater accuracy in predicting diabetes events occurring within the next 2-12 years in females than males with more consistent predictive thresholds in females.ConclusionsThis study highlighted a significant gender difference in the association between LAP and future diabetes risk. The risk of diabetes associated with LAP was greater in females than in males. Furthermore, LAP showed superior predictive ability for diabetes at different time points in the future in females and had more consistent and stable predictive thresholds in females, particularly in the medium and long term.