bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical Cancer Screening in Women With Physical Disabilities
Authors: Vinson Alexandra H. , Norrid Corrianne , Haro Elizabeth K. , Ernst Susan , El Khoury Christelle , Alves Martha L. , Kieber-Emmons Autumn , Kamath Mulki Ashwini , Butcher Emma A. , Kalpakjian Claire , McKee Michael M. , Harper Diane M. 
Published: January 2025

ImportanceCervical cancer screening is a crucial public health intervention, but screening disparities exist for women with physical disabilities (WWPD).ObjectiveTo explore the experiences of WWPD with both traditional speculum examination–based screening and at-home self-sampling for cervical cancer screening.Design, Setting, and ParticipantsThis qualitative study enrolled 56 WWPD to test self-sampling kits, provide feedback via a survey, and participate in a qualitative interview. An interprofessional team conducted semistructured interviews with 16 key informants and 40 pilot participants for 56 WWPD from November 1, 2021, through April 30, 2023. All completed a self-administered quantitative survey. Key informants’ experiences with 4 self-sampling devices helped determine which 2 self-sampling kits would be offered to participants in a pilot study.Main Outcomes and MeasuresA coding scheme was developed to represent inductive codes generated through preliminary coding and deductive codes representing domains from the Theoretical Domains Framework. This coding scheme was used to conduct a 2-pass thematic analysis.ResultsOf the 56 WWPD (mean [SD] age, 45.4 [9.1] years) who participated in the study, 28 (50.0%) were up to date with cervical cancer screening. Participants described accessibility barriers and clinician ableism that made speculum-based in-office examinations difficult, leading some participants to delay or avoid screening. In contrast, participants described self-screening as more comfortable and convenient, regardless of whether they prefer future speculum-based screening. Their responses also allowed for the exploration of how screening preferences may impact future screening behavior.Conclusions and RelevanceInterviews with WWPD suggested that access to self-sampling screening options would be more comfortable for cervical cancer screening participation. Understanding participants’ experiences with self-sampling devices generates insights into improving screening experiences for WWPD.
Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis
Authors: Hospach Toni , Blankenburg Friederike , Heinkele Anita , Rücklová Kristina , Müller‐Abt Peter , Weller‐Heinemann Frank , Buchtala Laura , Maier Jan , Kümmerle‐Deschner Jasmin , Reiser Christiane , Janda Ales , Urban Andreas , Berendes Reiner , Skrabl‐Baumgartner Andrea , Brunner Jürgen , Trauzeddel Ralf , Haas Johannes Peter , Holl‐Wieden Annette , Morbach Henner , Schnabel Anja , Brück Normi , Hahn Gabriele , Emminger Wolfgang , Valent Isabella , Borchers Regine , Klemann Christian , Tsiflikas Ilias , Klotsche Jens , Minden Kirsten , Hedrich Christian M. , von Kalle Thekla 
Published: January 2025

ObjectivePulmonary involvement in chronic nonbacterial osteomyelitis (CNO) is rare. Limited awareness results in diagnostic challenges, especially because malignancy or infection needs to be considered.MethodsBased on a survey shared among centers participating in the Kerndokumentation Deutsches Rheumaforschungszentrum (Germany), this study investigated clinical and imaging presentations, demographic features, treatment response and outcomes of pulmonary involvement in CNO (pCNO). Magnetic resonance imaging and computed tomography images were read centrally by an experienced pediatric radiologist.ResultsTwenty‐two patients with pCNO were included in this study. Among patients with CNO, pulmonary involvement was more common in girls (91% vs 62.8%, P = 0.006) and patients with multifocal bone lesions (95% vs 65%, P <0.001) but was not associated with systemic inflammation or additional organ involvement. Forty‐two pulmonary lesions were counted with a median of two per patient (two to six). They displayed a median size of 1.8 cm (0.3–4.0 cm) and followed mono‐ (40%) and oligo‐focal (60%) patterns representing consolidations or nodules, abutting the pleura in 50%. Although prominent hilar lymph nodes were present (in 19% of patients), no pathologic enlargement (>1 cm) was seen. When available (3 of 22 patients), histology revealed granulomatous inflammation with lymphocyte infiltration. Development and courses of pCNO did not associate with treatments chosen. Complete remission was reported in 60% of patients, partial remission in 20%.ConclusionpCNO is usually asymptomatic. Although more common in girls and patients with multifocal CNO, pCNO is not associated with systemic parameters of inflammation or specific organ involvement. Prognosis of pCNO is favorable, and most lesions resolve over time. Thus, a careful watch‐and‐wait strategy may be appropriate.
Non‐Enzymatic Destruction of the Extracellular Matrix for Activatable Orthotopic Tumor Treatment and Enhanced Drug Penetration
Authors: Wang Hui , Feng Ruxin , Wang Yan , Ma Qian , Yuan Di , Yang Xi , Xu Suying , James Tony D. , Wang Leyu 
Published: January 2025

AbstractThe controlled release and enhanced penetration of drugs to deep‐seated tumors is highly desirable but faces many challenges. Herein, supramolecular biomimetic nanoaggregates (HFCu NAs) are constructed with fluorinated histidine and copper ions via multivalent interactions (metal coordination and aromatic packing), affording tumor microenvironment responsive “turn‐on” 19F magnetic resonance imaging （19F MRI） guided drug delivery and specific tumor therapy. By virtue of ligand engineering and pH‐triggered conformation changes, HFCu NAs exhibit enhanced reactive oxygen species （ROS）generation due to lower pH levels at tumor sites, leading to the stepwise collapse of the extracellular matrix (ECM), which is analogous to targeted protein degradation, without requiring endogenous enzymes. Consequently, the breakdown of the ECM provides positive feedback for the permeation of HFCu NAs, thereby, significantly inhibiting orthotopic tumor growth with explicit immunogenic cell death. As such, the proposed platform exhibits significant potential as activatable drug delivery vehicles for enhanced drug permeation and therapy.
Asymmetric Structural Design for Absorption‐Dominated Electromagnetic Interference Shielding Composites
Authors: Zhou Meng , Yu Zan , Yan Qiming , Zhang Xinya 
Published: January 2025

AbstractExcessive electromagnetic pollution caused by electromagnetic waves can interfere with the normal use of electronic devices or cause unnecessary damage to human health. Although conductive polymer composites (CPCs) are used to replace traditional metals as an effective strategy for managing undesirable electromagnetic waves, CPCs have a non‐negligible trade‐off in the enhancement of electromagnetic interference (EMI) shielding effectiveness and absorption coefficient because of their reflection‐dominated EMI shielding mechanism. Therefore, to alleviate secondary electromagnetic pollution, absorption‐dominated EMI shielding composites with asymmetric structures are urgently needed. Recently, asymmetric structural designs for absorption‐dominated EMI shielding composites have advanced significantly, but have seldom been summarized and discussed in detail. Consequently, this review first systematically summarizes the current progress of absorption‐dominated EMI shielding composites with asymmetric structures after a brief clarification about the necessity and configuration of asymmetric structure design. Afterward, various absorption‐dominated EMI shielding composites with asymmetric fiber, layered, porous, composite structures are systematically described. Besides, the versatility of absorption‐dominated EMI shielding composites with asymmetric structures is briefly introduced. Finally, the current challenges and prospects are proposed to guide future advancement in the EMI shielding field.
A Super‐Chlorophobic Yet Weak‐Reconstructed Electrocatalyst by Fluorination Engineering toward Chlorine Oxidation‐Free and High‐Stability Seawater Electrolysis
Authors: Mu Jiawei , Yu Chang , Song Xuedan , Chen Lin , Zhao Jiarui , Qiu Jieshan 
Published: January 2025

AbstractDirect seawater electrolysis is key for achieving sustainable green‐hydrogen production and transitioning toward a decarbonized energy system. However, its performance is limited by significant challenges, mainly catalyst instability, which is caused by excessive reconstruction, low catalytic activity, and aggressive chlorine‐corrosion. Herein, high‐electronegativity F is introduced into NiFe layered double‐hydroxide (F‐NiFe‐LDH) through fluorination engineering to induce electron‐deficient regions around Ni, thus creating abundant intrinsic high‐valence Ni sites. Correspondingly, the features of weak reconstruction accompanied by high stability, chlorophobic surface, and high‐activity lattice oxygen are produced on the F‐NiFe‐LDH, confirmed detailedly by experiment and theory. Consequently, the F‐NiFe‐LDH exhibits a superior oxygen evolution reaction (OER) activity with low overpotentials of 306 and 375 mV to reach 500 mA cm−2 at alkaline simulated seawater and alkaline seawater, respectively. Also, it demonstrates a chlorine‐corrosion resistance, along with ultra‐stability seawater electrolysis for over 1000 h at 1000 mA cm−2 without performance degradation, structural collapse, or chlorine oxidation reaction. Furthermore, an anion exchange membrane electrolyzer assembled by the F‐NiFe‐LDH anode shows an energy consumption of only 4.87 kWh Nm−3 for hydrogen production. This work provides an inspiration for designing corrosion‐resistance electrocatalysts aimed at chlorine oxidation‐free seawater electrolysis, which simultaneously achieve high stability and OER activity.
Development of an Electron Emitter via Seamless Shaping of a 3D‐Printed Ceramic Cone With Carbon Nanotube Mesh Film as an Alternative to Polymer‐Based Materials
Authors: Laszczyk Karolina U. , Krol Konrad , Bialy Mateusz , Nowak Damian 
Published: January 2025

AbstractThis paper focuses on electron emitters formed using seamless hybrid shaping of the ceramic 3D‐printed cone (as a supporting structure) and a conductive emitting film obtained from the suspension of dispersed carbon nanotubes (CNT). The ceramic cone is post‐process fired to achieve a pure ceramic cone that is coated with emitting CNT mesh film. Meanwhile, a cone‐based polymer emitter is evaluated. The resulting emitter exhibits non‐linear current‐voltage characteristics reaching maximum 0.6 mA anode current with a turn‐on‐field voltage below 1 Vµm−1 and minimal current fluctuation over time. Additionally, the ceramic emitter arrays fabricated using the same technique are demonstrated: if the tip angle and shape in a microscale have tunability in emission is confirmed, meanwhile, the type of volatile gases released during the emission is confirmed using a residual gas analyzer (RGA). The motivation and challenge are to use 3D printing to enable freedom in designing and forming the emitter tip shape and angle and to present the perspective and challenges to use the 3D printing technique combined with the seamless shaping for the CNT mesh film to tune the emitter performance. Especially as this technique and 3D‐printed materials have not been previously employed for electron emitters.
A Simple Micro/Nano‐Porous Structure With Day‐Night Dynamic Thermal Control and High Thermal Conductivity for Enhanced Thermoelectric Power Generation
Authors: Lv Song , Deng Jingcai , Feng Mengqi , Zhang Mingming , Guo Ying , Wu Yangyang , Shi Guoqing 
Published: January 2025

AbstractThe main challenge of an all‐weather power generation system that combines radiative cooling and thermoelectricity is to dynamically regulate the temperature sources at both ends of the thermoelectric device. Previous studies have used stacked and flipped structures, thermochromic materials, and other methods. However, the above methods have complex structures, low thermal conductivity efficiency, and difficult‐to‐prepare materials. Therefore, in this paper, a porous structure of carbon nanomaterials with simple preparation, dynamically adjustable heat source during day and night, and high thermal conductivity in combination with thermoelectric devices with ultra‐high electrical efficiency is proposed. The structure has a solar spectrum absorption of 98.6%. Graphene film is used as a substrate material to enhance the longitudinal thermal conductivity. Experiments showed that the maximum voltage during day and night can reach 847 and 106 mV, the maximum temperature difference is 12.63 and 1.42 °C, and the maximum power density is 2112.96 mW m−2 when combined with thermoelectric devices. Simulation models are used to analyze the environmental sensitivity of power generation units and to predict their power generation potential. This work provides superior photothermal/radiative cooling structures combined with thermoelectric elements for efficient all‐weather energy conversion and power output.
Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3‐O‐UGT2
Authors: Ji Qiushuang , Liu Yirong , Zhang Huanyu , Gao Yan , Ding Yixin , Ding Yuanyuan , Xie Jing , Zhang Jianyu , Jin Xinghua , Lai Bin , Chen Cheng , Wang Juan , Gao Wenyuan , Mei Kunrong 
Published: January 2025

AbstractGinsenosides are a group of tetracyclic triterpenoids with promising health benefits, consisting of ginseng aglycone attached to various glycans. Pq3‐O‐UGT2, an important UDP‐dependent glycosyltransferase (UGT), catalyzes the production of Ginsenoside Rg3 and Rd by extending the glycan chain of Ginsenoside Rh2 and F2, respectively, with higher selectivity for F2. However, the mechanism underlying its substrate recognition remains unclear. In this study, the crystal structures of Pq3‐O‐UGT2 in complex with its acceptor substrates are solved. The structures revealed a Nα5‐oriented acceptor binding pocket in Pq3‐O‐UGT2, shaped by the unique conformation of the Nα5‐Nα6 linker. Hydrophobic interactions play a pivotal role in the recognition of both Rh2 and F2, while hydrogen bonds specifically aid in F2 recognition due to its additional glucose moiety. The hydrophobic nature of the acceptor binding pocket also enables Pq3‐O‐UGT2 to recognize flavonoids. Overall, this study provides novel insights into the substrate recognition mechanisms of ginsenoside UGTs, advancing the understanding of their function and specificity.
Modeling Sporadic Progressive Supranuclear Palsy in 3D Midbrain Organoids: Recapitulating Disease Features for In Vitro Diagnosis and Drug Discovery
Authors: Parrotta Elvira Immacolata , Lucchino Valeria , Zannino Clara , Valente Desirèe , Scalise Stefania , Bressan Davide , Benedetto Giorgia Lucia , Iazzetta Maria Roberta , Talarico Mariagrazia , Gagliardi Monica , Conforti Francesco , Di Agostino Silvia , Fiorenzano Alessandro , Quattrone Aldo , Cuda Giovanni , Quattrone Andrea 
Published: January 2025

ObjectiveProgressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP is challenging due to the lack of disease models reproducing its key pathological features. This study aimed to model sporadic PSP‐Richardson's syndrome (PSP‐RS) using multi‐donor midbrain organoids (MOs).MethodsThe MOs were generated by pooling induced pluripotent stem cells (iPSCs) from 4 patients with sporadic probable PSP‐RS and compared them with MOs from 3 healthy control (HC) subjects. We performed comprehensive analyses of MOs over 120 days to assess neuronal death, reactive gliosis, and the accumulation of 4R‐tau and hyperphosphorylated tau forms (pThr231, pSer396, pThr181, and pSer202/pThr205 [AT8]) using immunofluorescence microscopy and Western blot. On day 90, immunohistochemical analysis using pSer396 and AT8 antibodies was conducted to assess disease pathology.ResultsPSP‐derived MOs showed progressive size reduction compared with HC‐derived MOs, linked to upregulated apoptosis‐related mRNA markers. Dopaminergic neuron degeneration was marked by decreased tyrosine hydroxylase (TH) and increased neurofilament light chain (NfL). Immunofluorescence and Western blot revealed accumulation of all investigated tau forms with a peak at 90 days, along with a significant rise in GFAP‐positive cells in PSP‐derived MOs. Immunochemistry confirmed typical PSP histological alterations, such as neurofibrillary tangles and tufted‐shaped astrocytes, absent in HC‐derived organoids.InterpretationWe developed a robust in vitro PSP model reproducing the key molecular and histologic features of the disease. This result holds promise for advancing basic and clinical research in PSP, paving the way for in vitro molecular diagnosis and identification of novel therapeutic targets. ANN NEUROL 2025
Room Temperature Ethene to Propene (ETP) Tandem Catalysis using Single Crystalline Solid‐State Molecular Pre‐Catalysts
Authors: Altus Kristof M. , Shi Yiping , Probst Patrick , Heaton Jack H. , Gyton Matthew R. , Lari Leonardo , Buchmeiser Michael R. , Dyer Philip W. , Weller Andrew S. 
Published: January 2025

AbstractA tandem catalytic ensemble of solid‐state molecular organometallic (SMOM) crystalline pre‐catalysts are deployed under batch or flow conditions for the ethene to propene process (ETP). These catalysts operate at ambient temperature and low pressure, via sequential ethene dimerization, butenes isomerization and cross‐metathesis. Under flow conditions the on‐stream ethene conversion (55 %), initial propene selectivity (92 %), stability (71 % selectivity after 7 h) and low temperature/pressures are competitive with the best‐in‐class heterogeneous systems, marking a new, in crystallo, approach to ETP.
Unprecedented High Activity of One‐Dimensional Nickel‐Based Coordination Polymer for Ethylene Dimerization
Authors: Ning Yao , Li Changlian , Zhao Bo , Min Wenpeng , Li Xinyuan , Zhang Ying 
Published: January 2025

ABSTRACTThree kinds of one‐dimensional nickel‐based coordination polymers (1D‐S‐Ni, 1D‐D‐Ni, and 1D‐M‐Ni) with different coordination environments and topological structures were synthesized and evacuated as heterogeneous catalysts for liquid phase slurry reaction of ethylene dimerization. Their crystal structures, morphology, chemical groups, and thermal properties were characterized by PXRD, SEM, FT‐IR, TGA, ICP‐AES, and EA, respectively. The catalytic performance of these catalysts was examined under various reaction conditions, including the amount of cocatalyst, reaction temperature, and reaction pressure. These catalysts showed high catalytic activity up to 105–106 g/(molNi·h) and high selectivity of butene (C4) over 78% at room temperature and 10 atm pressure. Especially the catalytic activity of 1D‐D‐Ni was up to 17.1 × 105 g/(molNi·h), exceeding that of most Ni‐based heterogeneous catalysts and reaching the level of nickel‐based homogeneous catalysts. The stability and cyclic performance of 1D‐D‐Ni was also assessed. It was observed that the catalyst did not undergo decomposition during the reaction and maintained a high activity level of 12.0 × 105 g/(molNi·h) even after three cycles. 1D‐D‐Ni has SBU similar to homogeneous nickel‐based complex catalyst for ethylene dimerization, indicating that reasonable design of metal nodes is an effective way to synthesize heterogeneous ethylene dimerization catalysts with high catalytic performance.
A Comparative Study of Time to Initiate Chest Compressions and Chest Compression Fraction in the Supine and Prone Positions Using Simulation
Authors: Smith Zachary , Sessler Darren , Oermann Marilyn H. , Simmons Virginia C. 
Published: January 2025

ABSTRACTRepositioning a patient from the prone to supine position can delay the initiation of cardiopulmonary resuscitation (CPR). Investigators used high‐fidelity simulation to assess the time to initiate chest compressions and the time during which compressions did not occur for supine and prone CPR. Sixty participants completed a knowledge assessment before and after attending an education session and completing two simulations (ie, supine, prone). Mean (SD) knowledge scores improved from 48.7% (17.4%) to 85.3% (14.7%) after the education and simulations (t59 = −12.32, P < .001). Prone CPR resulted in a significant reduction in the time to initiate chest compressions (13 seconds, prone; 314 seconds, supine; t11 = −31.79; P < .001) and a higher chest compression fraction (84% prone versus 42% supine; t11 = 19.1, P < .001). When compared to repositioning to supine, prone CPR decreased chest compression interruptions, and may therefore be beneficial during the perioperative period.
Does the Digital Economy Promote Renewable Energy?—Evidence From a Cross‐National Sample
Authors: liu Lin , Liu Jing , Zhang Jianing , Zhao Yiyang 
Published: January 2025

ABSTRACTRenewable energy is one of the key factors in mitigating climate change and achieving sustainable development. With digital technology at its core, the digital economy has gradually become a new driving force for renewable energy development. However, few studies have examined the impact of the digital economy on renewable energy from a global perspective and explored the transmission mechanisms. Based on the cross‐country data of 68 countries (regions) from 2013 to 2021, this paper adopts a panel model to study the impacts of the digital economy on renewable energy. The results show that (1) digital economy has a positive impact on renewable energy; (2) the impact of digital economy on renewable energy is asymmetric and heterogeneous; (3) the impact of digital economy on renewable energy development has obvious threshold characteristics; (4) digital economy indirectly affects renewable energy through technological innovation and financial development. The research in this paper provides a theoretical basis for promoting renewable energy development and a reference and guidance for countries to realize sustainable development in the context of the digital economy.
Saccharinate‐Based Ionic Liquids and Lithium Battery Electrolytes
Authors: Ahmed Mukhtiar , Kushwaha Ashok , Filippov Andrei , Johansson Patrik , Ullah Shah Faiz 
Published: January 2025

AbstractFluorine‐free ionic liquids (ILs) and electrolytes based on ether‐functionalized pyrrolidinium or imidazolinium cations coupled with a “greener”, non‐basic, and hydrolytically stable saccharinate (Sac) anion, are herein presented with their thermal, transport and electrochemical properties. The thermal stability, glass transition temperature, and electrochemical stability of the imidazolinium based ILs surpasses the pyrrolidinium IL, while the latter offer better (ion) transport properties. Ether‐functionalization of the IL cation improves the transport properties with negligible effects on the thermal and electrochemical stabilities. The Li+ conducting electrolytes – created by adding 10 mol % of lithium saccharinate (LiSac) to the neat (BMMIm)(Sac) and (C201MMIm)(Sac) ILs show an as low initial overpotential as ±0.05 V and outstanding Li stripping/plating performance over 100 hours at 60 °C for the latter, but a very large polarization interfacial resistance, 4730 Ω cm2, impeding the kinetics of stripping/plating, even at these elevated temperatures for the former. Hence the rather modest modification has an enormous impact in practice.