bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEEDS OF ELDERLY PEOPLE AND POSSIBILITIES OF ITS REALIZATION IN MODERN CONDITIONS
Authors: Grybko Olga 
Published: October 2023

The article is devoted to the definition of such a multifaceted phenomenon as needs, as well as the search for ways to realize the needs of the elderly poeple in modern conditions.
It is established that needs are a complex phenomenon that reflects social life and develops under the influence of such components of social life as the economy, public administration and public policy, culture, education, etc. Satisfaction of needs to a greater extent depends on the interaction of a person with the social environment and is formed under the influence of society. It is because of the presence of needs that a person has motives for a certain activity.
Maslow’s extended pyramid of needs (7 levels) was used as the basis for the study of the needs of the elderly – where the first class of needs (physiological needs) includes: the need for healthy food, the need for clean drinking water, the need to maintain an acceptable temperature in the place of residence, the need for support health and treatment, the need for movement, the need for rest, the need for financial means to meet the above needs. The next levels of needs, respectively, are the need for security, the need for love and belonging to a group, the need for respect and recognition, cognitive needs, aesthetic needs, and the need for self-realization.
The article considers two essential modern aspects of realization of the needs of the elderly. First, it is a rapid change in needs under the influence of scientific and technological progress and globalization. And secondly, these are the conditions for meeting the needs in the context of the 2020-2021 lockdowns and the effect of martial law from February 2022. It was determined that the third and fourth levels of needs increase in elderly people during the pandemic and in the conditions of martial law: the needs for belonging to a group, love, respect and trust.
Factors Effecting Intention to Leave at Fajar Surya
Authors: Rifai Amirudin Lukmansyah Rifai Amirudin , Madhakomala  , Wibowo  
Published: October 2023

Turnover is a level of employee exit in a company. This research aims to develop an impact strategy model of job insecurity, career development opportunity, work involvement and work engagement on turnover intention. Quantitative methods are used ini this research. The sample consists of 150 employees with a managerial level. The sample criteria in this research are permanent employees and have worked for at least 3 years. Data collection techniques by distribution questionnaires directly to all samples. The data analysis used is SEM-PLS (Structural Equation Modeling - Partial Least Square). The results showed that job insecurity, career development opportunity and work engagement have significant influence on turnover intention. Career development opportunity and work engagement have negative and significant impact on turnover intention, while job insecurity has negative and significant impact on turnover intention. Job insecurity and career development opportunity mediated by work engagement have significant influence on turnover intention. Meanwhile, work engagement as mediating variable has no significant impact on turnover intention.
Folded calcite cracks in noncalcareous shales: a window into shale diagenesis and hydrothermal influence
Authors: Sun Bin , Yang Wan 
Published: October 2023

ABSTRACT
Shale diagenesis is not well understood, and cracks in shale contain important information about diagenetic conditions. The way these cracks open reveals physical changes in the sediment, and the infilling minerals provide insight into the chemical conditions of the formation water. Typically, the authigenic minerals filling the folded cracks are consistent with the chemical composition of the host rocks. For example, folded calcite cracks are found in limestone. This paper, however, focuses on a set of folded calcite cracks in noncalcareous black shales. The goal is to improve our understanding of shale diagenesis by deciphering the origins of these cracks. The cracks are sinuously to ptygmatically folded in a vertical view and weakly sinuous on the bedding plane. They are filled with calcite, bitumen, pyrite, or a combination of them. Evidence of bioturbation and low redox-sensitive trace-element ratios suggest suboxic to oxic depositional conditions of the shale. The cracks were likely opened by gas expansion in unconsolidated mud. The main mineral filling the cracks, calcite, was sourced from hydrothermal fluid that passed through the underlying dolomite. Hydrothermal influences are indicated by the presence of bornite and microcrystalline pyrite in the cracks, as well as Fe and Mn enrichment in the host sediments. Hydrothermal activity can also explain the presence of buddingtonite, an ammonium feldspar in the shale. The results of this study suggest that folded cracks filled by minerals, gradually narrowing towards the top, and lacking internal detrital matrix are likely formed during early diagenesis. The inconsistency between the chemical compositions of the infilling material and the host sediment requires further exploration to identify the source. Hydrothermal fluid passing through the underlying dolomite may be the source of folded calcite cracks in noncalcareous sedimentary rocks. These cracks resemble molar-tooth structures (MTS), which are sinuous cracks filled with microcrystalline calcite mostly found in Precambrian limestone and calcareous shales. If these cracks are indeed MTS, they may be an exception to the age and host-rock lithology constraints of MTS.
Identification of self- and pathogen-targeted miRNAs from resistant and susceptible Theobroma cacao variety to black pod disease
Authors: Septiani Popi , Pramesti Yonadita , Ningsih Devi Ulfa , Pancaningtyas Sulistyani , Meitha Karlia 
Published: October 2023

Abstract
Cacao (Theobroma cacao) is a highly valuable crop with growing demands in the global market. However, cacao farmers often face challenges posed by black pod disease caused by Phytophthora spp. with P. palmivora as the most dominant. Regulations of various gene expression influence plant resistance to pathogens. One mechanism involves targeting mRNA of virulence genes in the invading pathogens, suppressing their infection. However, resistance also could be suppressed by plant-derived miRNAs that target their own defense genes. The objective of this study is to identify differentially expressed miRNAs in black pod resistant and susceptible cacao varieties and to predict their targets in T. cacao and P. palmivora transcripts. In total, 54 known miRNAs from 40 miRNA families and 67 Novel miRNAs were identified. 17 miRNAs were differentially expressed in susceptible variety compared to resistant one, with 9 miRNAs were upregulated and 8 miRNAs downregulated. In T. cacao transcripts, the upregulated miRNAs were predicted to target several genes, including defense genes. The suppression of these defense genes can lead to a reduction in plant resistance against pathogen infection. While in P. palmivora transcripts, the upregulated miRNAs were predicted to target several genes, including P. palmivora effector genes. In the future, limiting expression of miRNAs that target T. cacao's defense genes and applying miRNAs that target P. palmivora effector genes hold promise for enhancing cacao plant resistance against P. palmivora infection.
Clinical importance of serum miRNA levels in breast cancer patients
Authors: TURKOGLU Fatih , CALISIR Akin 
Published: October 2023

Abstract
There is limited data on the relationship of miRNAs with parameters that may affect surgical management or reflect tumour prognosis. It was aimed to evaluate serum miRNA levels in breast carcinoma cases and reveal the relationship between these levels and prognosis-related factors such as the histological type of the tumour, estrogen receptor, progesterone receptor, Ki-67 index, HER-2neu, E-cadherin, tumour size, CK5/6, CA15.3 levels, number of tumour foci, number of metastatic lymph nodes, and status of receiving neoadjuvant therapy. Thirty-five patients with a histopathologically confirmed breast carcinoma diagnosis in the case group and 35 healthy individuals in the control group were examined. miR-206, miR-17-5p, miR-125a, miR-125b, miR-200a, Let-7a, miR-34a, miR-31, miR-21, miR-155, miR-10b, miR-373, miR-520c, miR-210, miR-145, miR-139-5p, miR-195, miR-99a, miR-497 and miR-205 expression levels in the serum of participants were determined using the Polymerase Chain Reaction method. While serum miR-125b and Let-7a expression levels were significantly higher in breast cancer patients, miR-17-5p, miR-125a, miR-200a, miR-34a, miR-21, miR-99a and miR-497 levels were significantly lower in them. The Let-7a expression level had a statistically significant relationship with breast cancer histological type and HER-2neu parameters, miR-17-5p, miR-125b, Let-7a, miR-34a, miR-21 and miR-99a levels with E-cadherin, miR-34a, miR-99a and miR-497 with CA15.3, miR-125b, miR-200a and miR-34a with the number of metastatic lymph nodes, miR-125a with the number of tumour foci and miR-200a with the status of having the neoadjuvant therapy. Serum miR-17-5p, miR-125a, miR-125b, miR-200a, Let-7a, miR-34a, miR-21, miR-99a and miR-497 expression levels were determined to have predictive and prognostic importance in breast cancer.
Mesoscale columnar-like organization of face and body areas
Authors: Vanduffel Wim , Li Xiaolian , Zhu Qi , Popivanov Ivo , Vogels Rufin 
Published: October 2023

Abstract
Segregated networks of columnar-like functional units convey highly specific functional signals within and across early visual areas. It is unknown, however, whether higher-order category-selective areas exhibit a similar mesoscale functional organization, nor whether mesoscale functional units are aggregated in functional networks spanning large distances (e.g. across hemispheres). Using sub-millimeter fMRI and single-cell recordings, we found that neurons with functionally similar tuning properties within face-and body-selective areas are spatially grouped into columnar-like mesoscale functional units, which also show segregated interhemispheric connectivity patterns. Hence, mesoscale functional networks may constitute fundamental architectural features of primate cortex.
Quality of Life after Obstetric Fistula among Women in Developed Countries
Authors: Neville Casey W. 
Published: October 2023

Abstract

This research aimed to evaluate the correlation between the experience of obstetric fistula and quality of life. Extensive research exists explaining obstetric fistula and the associated effects among women in underdeveloped countries; however, there is a lack of research pertaining to women who have experienced this condition in developed countries. We surveyed women who experienced obstetric fistula in developed countries. Participants were identified by their association with a social media support group for women affected by obstetric fistula (n= 68). Participants completed the Ferrans & Powers Quality of Life Index to provide data relating to their perceived quality of life after experiencing obstetric fistula. An overall score calculated from four subscales determined total quality of life scores. Each scale evaluated the participants’ perception of their satisfaction and the importance of particular items and assigned a score from 0-30 based on participant response. Quality of life scores ranged from 4.27 to 29.58, with an average score of 19.4. The results revealed a significant correlation between obstetric fistula and diminished quality of life. The subscale with the lowest scores was the Health and Functioning subscale with a minimum score of 1.12 and maximum score of 29.54.
Identification of Immune-related Core Genes Based on Immune Signatures of Age-related Macular Degeneration
Authors: Ge Panpan , Cao Guoping , Zhou Kun 
Published: October 2023

Abstract
Background: Age-related macular degeneration (AMD) is a disease that affects the retina and choroid and is the leading cause of blindness in older adults. Despite the prevalence of this disease, its etiology and pathogenesis are unknown, and many studies have shown that the immune system plays an important role in the development and progression of age-related macular degeneration. Here, we aimed to explore the immune profile of different stages of age-related retinopathy and to identify immune-related biomarkers that could improve the treatment of patients with age-related retinopathy.
Methods: Publicly available gene expression profiles of AMD samples at different stages of the disease were downloaded from the GEO database (GSE115828 dataset). The activity of 19 immune signatures in AMD retinal samples was assessed using ssGSEA, and the changes in immune levels at different stages of AMD were compared. Differential expression analysis was performed on advanced AMD samples, and the screened immune-related differentially expressed genes (DEGs) were used as a candidate gene set. We constructed an AMD-related model based on AMD immune-related DEGs by logistic regression and least absolute shrinkage and selection operator (LASSO), which was also verified by ROC curve. Finally, protein-protein interaction (PPI) networks were mapped using STRING and further analyzed using Cytoscape software.
Acute Toxicity Profile of Crude Methanolic Stem Bark Extract of Parkia Biglobosa in West African Dwarf (Wad) Goats
Authors: Josiah James Gana , Adama John Yisa , Obi Okechukwu Anthony , Etta Hannah Edim 
Published: October 2023

Abstract

Despite the high demand for herbal medicines for treatment of health disorder, there are still concerns associated with not only their use, but their safety. This study aimed at providing information on the potential toxicity profile of the stem bark extracts of P. biglobosa in goats. For this purpose, the stem bark parts of P. biglobosa were collected and processed. The acute toxicity, biochemical and histopathological analysis in goats were determined. The results of phytochemical constituents revealed the presence of alkaloids, anthraquinones, cardiac glycosides, glycosides, oils, phlobatannins, reducing sugar, saponins and tannins (condensed and hydrolysable). The results of acute toxicity studies showed no mortality with up to 5000 mg/ kg of the body weight. The blood collected revealed that, CMSBE, have no significant (P>0.05) effect on biochemical parameters of WAD goats . However, there were slight changes in glucose concentration, cholesterol and triglyceride level, though they were no statistically significant (P>0.05). The extracts did not also have deleterious effect on morphology of the tissues observed during histopathology. The study has scientifically demontrated that, stem bark extract of P. biglobosa have LD50 that is greater than 5,000 mg/kg and it can be inferred that the plant might have a wide margin of safety typical of treatment of some diseases. It is therefore recommended that despite the non-toxicity as demonstrated in this present study, detailed toxic and pharmacological effects of the extracts of P. biglobosa stem bark in other animals should be investigated.
Mean-field Libor market model and valuation of long term guarantees
Authors: Gach Florian , Hochgerner Simon , Kienbacher Eva , Schachinger Gabriel 
Published: October 2023

Abstract
Existence and uniqueness of solutions to the multi-dimensional mean-field Libor market model (introduced by [7]) is shown. This is used as the basis for a numerical asset-liability management (ALM) model capable of calculating future discretionary benefits in accordance with Solvency~II regulation. This ALM model is complimented with aggregated life insurance data to perform a realistic numerical study. This yields numerical evidence for heuristic assumptions which allow to derive estimators of lower and upper bounds for future discretionary benefits. These estimators are applied to publicly available life insurance data.
Hydraulic conductivity and particle size of soils: model and prediction
Authors: Liu Jinyang , Ren Xingwei 
Published: October 2023

Abstract
This paper presents an analysis of the relationship between the saturated hydraulic conductivity and the particle size of soils ranging from the coarse- to fine-grained ones. Based on the most widely used Kozeny-Carman (KC) model, a concept of equivalent particle size (or equivalent particle radius) considering adsorbed water film is introduced to derive a new simple hydraulic conductivity prediction model. This model is evaluated by using experimental data from this study and existing literature, and demonstrates satisfactory predictive capability for a wide range of soils. Moreover, this article discusses the reasons why the KC model is not applicable for predicting the hydraulic conductivity of fine-grained soil, and proposes a criteria in terms of critical particle size for determining the applicability of the KC model. The critical particle size is 1.0 × 10-3 mm determined by both the numerous experimental data and the comparison between the KC model and the proposed model. It further provides a threshold particle size of 1.0 × 10-5 mm as the minimum particle size for pore water flowing among soil particles.
A pulsed hollow cathode discharge operated in an Ar/N2/O2 gas mixture and the formation of nitric oxide.
Authors: Hippler Rainer , Cada Martin , Knizek Antonin , Ferus Martin , Hubicka Zdenek 
Published: October 2023

Abstract
A hollow cathode discharge with a CuNi (Cu50Ni50) cathode was operated in an Ar/N2/O2 gas mixture. The energy distribution of plasma ions is investigated with the help of energy-resolved mass spectrometry. Formation of singly ionised Ar+ and of Cu+ and Ni+ ions is observed in pure argon. With the addition of N2 or O2 gas the additional formation of molecular N2+ or O2+ ions is observed. The intensity of these ions is reduced in the Ar+N2+O2 gas mixture and molecular NO+ ion becomes the most abundant ionic species. The formation of neutral NO molecules is confirmed by optical emission spectroscopy. Gas samples collected at the exhaust of the vacuum chamber confirm the formation of NO and, additionally, of NO2 molecules.
Italian Evaluation and Excellence in REMS (ITAL-EE-REMS): Appropriate placement of forensic patients in REMS forensic facilities
Authors: Parente Lia , Carabellese Fulvio , Felthous Alan , Tegola Donatella La , Davoren Mary , Kennedy Harry G , Carabellese Felice F. 
Published: October 2023

Abstract

Background
We set out to assess the appropriateness of current placement of mentally disordered offenders allocated by the courts in Italy to REMS or to forensic community residences. We hypothesised that as in other countries, the match between a standardised assessment and the decision of the court would be imperfect.
Methods
The DUNDRUM Toolkit was translated into Italian. The translation had good psychometric properties. In order to compare the current level of therapeutic security with a calculated safest current placement, we compared the DUNDRUM-1 triage security assessment of need for therapeutic security prior to treatment, with evidence for progress made in treatment (DUNDRUM-3) and forensic recovery (DUNDRUM-4). The more conservative of these two would be taken as the safe current level of need for therapeutic security
Results
The Italian translation of the DUNDRUM Toolkit had good internal consistency and mean scores had a Reliable Change Index less than one unit. 3.7% of those in REMS (medium security0 were assessed as needing high security and 38% were ready to move to a less secure place. In low secure places, 56% were assessed as needing a higher level of therapeutic security and 6% could have moved to open non-secure places.
Conclusions
The Italian translation of the DUNDRUM Toolkit allows an assessment of the current working of the model of care for forensic psychiatry following the reforms of 2015. Most patients are safely placed. A small but important proportion needed high secure places that are not currently available. (3.7% of 604 nationally, 95% Confidence Interval 1.2–8.4%, 7 to 50). A greater use of such measures would enable better health gains and safer outcomes.
Trial registration
ClinicalTrials.gov ID: NCT06018298 Unique Protocol ID: ITAL-EE-REMS
Brief Title: Evaluation of Excellence in Italy's Residence for Execution of Security Measure
(ITAL-EE-REMS). 31st August 2023.
On an objective, geometrically exact coupling element for a director-based multi-body finite element framework
Authors: Märtins David , Schuster Daniel , Hente Christian , Gebhardt Cristian Guillermo , Rolfes Raimund 
Published: October 2023

Abstract
In multi-body systems, flexible components as well as couplings between them can be subject to large displacements and rotations. This contribution presents a general objective and geometrically exact node-to-node coupling element pursuing two innovations.Firstly, the coupling element represents a consistent contribution to an existing nonlinear mechanical framework. The coupling element intends to preserve its attributes of objectivity, path-independence, and adherence to the energy-conserving or energy-dissipative time integration method. Secondly, besides elasticity also inertia and damping properties are considered.For this purpose, a director-based formulation is employed within a total Lagrangian description. The avoidance of an angle-based representation, along with the additive update of state variables, results not only in path-independence but also in the avoidance of accumulating errors during extended simulations. An objective deformation measure is chosen based on the Green-Lagrange strain tensor. The inertia forces are considered by an arbitrarily shaped continuum located at the centre of the coupled nodes. Damping is considered by two different objective first order dissipation functions, which further ensure energy conservation or dissipation.We successfully demonstrate the coupling element within the mechanical framework on exemplary applications. Firstly, the geometrically exact behaviour is shown compared to a linear deformation measure. Secondly, we numerically indicate the path-independence of the formulation. The dynamic behaviour is demonstrated in a transient analysis of a damped structure. Finally, the modal analysis of a wind turbine shows the application of the coupling element to model the soil-structure interaction.
Band-limited interactions between mask and target in continuous flash suppression
Authors: Drewes Jan , Zhu Weina 
Published: October 2023

Abstract
Continuous Flash Suppression (CFS) has become a widely-used technique in the study of visual perception without conscious awareness, even though key aspects of the underlying neural mechanisms are not well known. Here we analyze the effect of overlapping and non-overlapping spatial frequencies between systematically aligned masks and targets, showing strong interactions exist in both cases. These interactions may significantly prolong CFS response times (up to several hundred milliseconds, or more than twice the suppression duration compared to baseline) but are attenuated in case of absence of overlap, even completely absent in certain cases. Our results provide insights for the design of bias-free masks in CFS experiments and will be useful to avoid mask-induced biases in CFS studies, which might otherwise be misinterpreted as differences in unconscious processing of visual stimuli.