bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Warning Signs for Complications of Human Brucellosis: A Multi-center Observational Study from China
Authors: Shi Qingnan , Qin Hui-Jie , Lu Qiao-Shan , Li Shu , Tao Zhong-Fa , Fan Meng-Guang , Aishan Mu-Heta , Kou Zeng-Qiang , Chen Qiu-Lan , Yin Wen-Wu , Zhang Yan-Ping 
Published: November 2023

Abstract
background
Brucellosis is one of the most serious “ignored zoonoses” in the world and especially affects poverty-stricken nations. Early diagnosis of focal complications in brucellosis increases treatment success. However, up to now, no clear joint indicators of symptoms or biomarkers for the diagnosis of complications. Hence, we investigated the warning signs of focal complications in human brucellosis aimed to provide practical parameters for clinicians in patients diagnosis and management.
Methods
A multi‑center cross‑sectional study was conducted in China from December 2019 to August 2021. The clinical characteristics and complications of brucellosis patients were based on questionnaire survey and medical record system. Warning signs of complications were assessed by univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used for variable screening and model evaluation.
Results
A total of 880 participants of human brucellosis were enrolled. Of the patients, median age was 50 years [interquartile range (IQR):41.5,58.0] and 54.8% had complications. The complication involved any organ, common in osteoarticular system (43.1%), including peripheral arthritis (30.0%), spondylitis (16.6%), paravertebral abscess (5.0%) and sacroiliitis (2.7%); followed by genitourinary system (4.7%), respiratory system (4.7%), and hematologic system (4.6%). Long delay in diagnosis [odds ratio (OR):3.963, 95% confidence interval (CI):1.906–8.238 for > 90days], underlying disease(OR:1.675, 95%CI:1.176–2.384), arthralgia(OR:3.197, 95%CI:1.986–5.148), bulging pain(OR:3.482, 95%CI:1.349–8.988), C-reactive protein (CRP) > 10 mg/L (OR:1.910, 95%CI:1.310–2.784)and erythrocyte sedimentation rate (ESR) elevation (OR:1.663, 95%CI:1.145–2.415)were the relevant factors for focal brucellosis. The optimal cutoff value in ROC analysis was > 5.4 mg/L for CRP (sensitivity 73.4% and specificity 51.9%) and > 25 mm/h for ESR (sensitivity 47.9% and specificity 71.1%).
Conclusions
Over half of brucellosis patients suffered complications. Diagnostic delay, underlying disease, arthralgia, bulging pain, and high CRP and ESR were significant relevant markers of complications. Regardless of culture results and standard tube agglutination test (SAT) titers, patients with these conditions should be on the alert for complications.
Estimates of Combining Ability in Spring-Summer Sorghum [Sorghum bicolor (L.) Moench] for Yield and some Morphological Traits Using Line X Tester Analysis
Authors: Bhadouriya Gyan Pratap Singh , Bhadouriya Narendra Singh 
Published: November 2023

Abstract
In kharif-2022 at crop research centre-1 of ITM University, Gwalior situated in gird agroclimatic zone of Madhya Pradesh, (India). eight sorghum genotypes were crossed following line x tester mating design giving rise to 15 hybrids which were cultivated during spring-summer season 2023 at same place to estimate the combining ability. Hybrids were evaluated for yield and its allied characters namely Days to 50% flowering, Days to maturity, Plant height (cm), Number of leaves, Leaf length (cm), Leaf breadth (cm), Leaf area (cm2) and 1000 seed weight (gm). For all the characters under study non additive gene action was predominant as σ2 GCA/ σ2 SCA ratio was less than unity. It was observed that line CSV 15 and tester RVJ 1862 were good combiners for grain yield per plant while JJ 1022 was a good combiner for plant height, crosses JJ 1022 x JJ 938 and SPV2376 x RVJ 1862 was found desirable for plant height. SPV 2688 x RVJ 1862 and SPV2376 x JJ 938 were found good for grain yield per plant.
Ship path-tracking with real disturbance and exponential cost function
Authors: Zhang Lihao 
Published: November 2023

Abstract
Intelligent ship technology is currently an international research hotspot, and model predictive control is widely used in the path-tracking control of intelligent vehicles. To construct an intelligent ship anti-disturbance path-tracking control method, firstly, an environmental disturbance model was constructed with the actual meteorological data of the target sea area. Secondly, the Fossen ship equation of motion is linearized and discretized as the ship motion model. Thirdly, the expression of the prediction equation is derived from the ship motion model. Fourthly, the cost function is constructed by using the polar diameter and polar angle values of the ship. Fifth, the power function in the cost function is replaced with an exponential function to obtain an improved cost function. Sixthly, according to the Lyapunov theory and the MPC terminal constraint theory, the stability of the improved cost function is verified. Seventh, different test paths are set up, the environmental disturbance model is taken as the external disturbance, the ship motion model, the prediction equation, and the improved cost function are used to design the anti-disturbance path-tracking control algorithm according to the model prediction control idea for simulation experiments. Finally, different MATLAB simulation results show that the improved cost function can resist disturbance of the external wave, current, and wind, and effectively track the target path. Therefore, this study provides a reference for improving the navigation safety of ship path-tracking.
A SEER-Based Analysis of Trends in HPV-associated Oropharyngeal Squamous Cell Carcinoma
Authors: Kim Su Il , Lee Jung Woo , Eun Young-Gyu , Lee Young Chan 
Published: November 2023

Abstract
Background
The trends in the incidence of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) according to various epidemiologic factors have not been analyzed in detail in previous studies. We aimed to evaluate the trends of HPV-associated OPSCC in the United States.
Methods
This retrospective cohort study included 13081 patients with OPSCC from large population-based data using Surveillance, Epidemiology, and End Results (SEER) 2010–2016 database. Patients were diagnosed with OPSCC primarily in the base of tongue, posterior pharyngeal wall, soft palate, and tonsil and were tested for HPV infection status. We analyzed how the trends in the incidence of patients with OPSCC changed according to various demographic factors. Additionally, we forecasted and confirmed the incidence of HPV (+) and (-) patients with OPSCC using the autoregressive integrated moving average (ARIMA) model.
Results
The incidence of HPV (+) patients with OPSCC has increased over the past 7 years, but the degree of increase varied greatly according to the age, sex, and subsites. The incidence of HPV (-) patients increased until 2014 in all age and sex groups for each site, but did not show clear increasing tendency since then. Appropriate ARIMA models were applied to forecast the incidence of HPV (+) and (-) patients, and the predicted data matched the actual data well.
Conclusion
This large population-based study suggests that the trends of the incidence in HPV (+) patients with OPSCC has increased and will continue to increase. However, the trends of HPV (+) and (-) patients differed greatly according to various demographic factors. These results present a direction for establishing appropriate preventive measures to deal with HPV-related OPSCC in more detail.
A novel alternavirus with three dsRNA segments from Fusarium pseudograminearum, the pathogen of Fusarium Crown Rot in wheat
Authors: Liu Fuyu , Xia Lele , Cao Shulin , Sun Haiyan , Chen Huaigu , Deng Qingchao , Li Wei 
Published: November 2023

Abstract
Three dsRNA sequences were detected from the Fusarium pseudograminearum strain CF14029, a pathogen causing Fusarium Crown Rot in China. Characterization and sequencing analyses confirmed that these dsRNA sequences originated from the same virus. The virus consists of three dsRNA segments: dsRNA1 (3,560 nt in length) encoding an RNA-dependent RNA polymerase (RdRp), dsRNA2 (2,544 nt in length), and dsRNA3 (2,478 nt in length) which encodes a coat protein (CP). Phylogenetic analysis based on the RdRp and CP amino acid sequences revealed a high similarity of this virus with alternaviruses isolated from other Fusarium fungi of the genus Alternavirus within the family Alternaviridae. As a novel member of the Alternavirus genus, this virus is provisionally named Fusarium pseudograminearum alternavirus 1 (FpgAV1). Similar to other alternaviruses in Fusarium fungi, the positive-sense strand of each genomic dsRNA of FpgAV1 possesses a poly(A) tail and a distinctive 5'-terminal nonamer sequence (5’-GGC TGT GTG-3’). This study represents the first comprehensive description of the genomic sequence of an Alternavirus identified in F. pseudograminearum.
Effects of Different Nitrogen Flow Rates on Structure and Optical Characteristics in AlN Films by Reactive Magnetron Sputtering
Authors: Zhu Chunyan 
Published: November 2023

Abstract
AlN coatings were deposited on Si (100) substrates by reactive magnetron sputtering with nitrogen-to-argon flow ratios being varied. The main focus of this study was to analyze and provide a theoretical explanation for how the N2 flow ratio affects the crystal structure, surface morphology, and optical properties of films oriented along the C-axis. The findings indicated that AlN films displayed the highest level of stability and premium quality when the N2 flow ratio was set at 40%. X-ray diffraction analysis demonstrated prominent (002) diffraction peaks for AlN films obtained at varying N2 flow levels between 20% and 50%. Furthermore, the examination conducted via scanning electron microscopy demonstrated that higher N2 flow ratios resulted in an improved structural order of the films on the (002) crystal plane, ultimately leading to enhanced preferred orientation. Through the manipulation of the N2 flow ratio, the deposition rate and optical characteristics were effectively improved. These findings have significant implications for improving the crystalline quality of AlN films made through sputtering. Furthermore, this study explores the relationship between the N2 flow ratio and performance parameters of the films, which facilitates their application in optoelectronic and electronic devices.
Robustness of Civil Aviation Air Cargo Network Based on Scara Robot Dynamics Model
Authors: li lin , Zhang ya 
Published: November 2023

Abstract
As an integral part of the civil aviation network, the freight network is an indispensable and important channel in the logistics and transportation. As the construction of the cargo network continues to increase, the environment has become more complex. The challenges posed by its risks place higher demands on the robustness of the freight network. The improvement of network robustness, the establishment of preventive measures, and the stabilization of transportation network are the basis for health management and construction of aviation network. Therefore, in this paper, the robustness of the civil aviation air cargo network was deeply studied by combining the SCARA robot dynamics model. On the basis of the general situation of the development of the freight network, a basic understanding of the complex characteristics of the network structure was obtained. Then the robustness analysis provided support for the subsequent network optimization, and a robust controller was constructed using the dynamic model. Finally, the network state changes under random attack and selection attack were observed through simulation experiments. The simulation data has showed that the degree of change in the outer freight network after re-identification and optimization is very significant. The growth rates of the number of routes, average degree, network efficiency and clustering coefficient were 12.16%, 10.07%, 13.14% and 5.47%, respectively, the average path length also decreased by 4.63% due to the increase of isolated nodes. This shows that the optimal control under the SCARA robot dynamics model improves the overall robustness of the civil aviation air cargo network, which has important practical value for planning and improving the structure of the air cargo network, maintaining stable cargo transportation capacity, and improving logistics efficiency.
The effect of silicon on the oxidation behavior of iron aluminide produced using powder metallurgy
Authors: Khoshhal Razieh , Masjedi Abbas , Abad Seyed Vahid Alavi Nezhad Khaili 
Published: November 2023

Abstract
Iron aluminides are widely considered the most important materials due to their lightweight, low cost, easy sintering, and resistance to oxidation and sulfidation. The presence of silicon in some alloys containing aluminum has had positive effects on their oxidation resistance. Few researchers have addressed the effect of silicon on the oxidation behavior of iron aluminide which is formed using elemental powders of Fe, Al, and Si. Therefore, in this research, the amount of silicon was changed and the effects of Si content on the oxidation behavior of iron aluminide were investigated. To achieve this goal, the elemental powders of Fe and Al (with a molar ratio of 1:1) along with different amounts of Si were pressed and sintered at 950°C. The samples were oxidized in air at temperatures of 600°C, 700°C, and 800°C, consequently. The findings confirm that silicon up to a certain content can improve the oxidation resistance of iron aluminide. The morphology of the obtained phases is influenced by the amount of silicon as well.
Controlled Low Strength Material with Waste Materials for Trench Filling in Expansive Soils and Contaminated Sites
Authors: J Sumalatha , C Nataraja M , L Sivakumar Babu G 
Published: November 2023

Abstract
Expansive soils exerting swelling pressures can lead to structural damage in underground utilities like foundations and pipelines. To address this issue, non-swelling materials can be used as substitutes for backfilling trenches. Controlled Low-Strength Material (CLSM) serves as a suitable alternative and can be prepared using industrial wastes and by-products. The objective of this research work is to replace the conventional filling materials with CLSM, especially in areas where swelling soils exert pressure on sewer pipes, water pipes, and structure footings. To ensure sustainability, industrial wastes like crumb rubber, arecanut fiber, and coconut fiber are incorporated to create the CLSM. From the compression tests, the ideal CLSM mixture identified was 1:10:25 of Cement: Flyash: Sand, with 5% Rubber, 0.2% Arecanut fiber, and 0.2% Coconut fiber. The swelling pressure of black cotton soil estimated by constant volume method was 317.65 kPa, which is relatively high. Consequently, replacing the swelling soils with CLSM emerges as a viable solution to prevent structural damages in lightweight structures. The utilization of CLSM in contaminated soils was also studied as the pollutants in the soil may cause structural damages to the foundation materials. The soil and CLSM materials were filled in trenches and the leaching tests were conducted with copper and zinc solutions of 1000 ppm. From the results, it was found that the CLSM prepared using waste materials is effective in reducing the migration of metals through it and hence it can be effectively used as a trench filling material in contaminated sites.
Prevalence of, and risk factors for, recurrent episodes of depressive or anxiety disorders: A Systematic review
Authors: Brooks Samantha K. , Hall Charlotte E. , Greenberg Neil 
Published: November 2023

Abstract
Background
Previous research papers have suggested that with each successive episode of depression or anxiety disorder the chance of recurrence significantly increases. However, the causes of such recurrences have been less well studied. Indeed, studies often report multiple, often conflicting, risk factors. The current review aimed to systematically collate recent literature on this topic to both estimate the likelihood of recurrence after an initial episode of depression or generalised anxiety disorder and elucidate factors which make recurrence more or less likely.
Methods
In May 2022, searches were conducted across four electronic databases: Medline, Global Health, PsycInfo and Embase for records published in English since 2018 in peer-reviewed journals reporting on the prevalence of recurrence of depressive/anxiety disorders, or risk factors for recurrence of depressive/anxiety disorders.
Results
A total of 2,173 citations were screened and 36 papers were included in the review. Recurrence rate reported in the retained papers ranged from 11.6–91.8%, with a mean and median recurrence rate of 42%. There was limited consensus on factors associated with recurrence, but previous experience of trauma, especially during childhood, was found to be the most predictive.
Limitations:
Grey literature was not included within this review which may have resulted in a loss of potentially important studies.
Conclusion
We found no evidence that disease-related factors were predictive of relapse. Instead, our results also showed that, other than exposure to prior trauma, there was no clear consensus as to what risk factors impacted risk of recurrence. Suggestions for future research are suggested.
The causal role of immune cells in rheumatoid arthritis: a Mendelian randomization study
Authors: yang wei , Li Zhenhua , Han Xiuzhen , Cui Miao , Han Mingze , Yu Jianan , Qu Yi , Shi Haorui 
Published: November 2023

Abstract

Objective
Rheumatoid arthritis (RA) is a chronic, systemic, and inflammatory disease of unknown etiology, mainly affecting synovial joints, resulting in severe pain, stiffness, limited function, poor quality of life, and work disability. However, the current pathogenesis of RA is not very clear, and autoimmunity may be one of its causes. The complex immune factors that affect the transition between pro-inflammatory and inflammatory phenotypes may play an important role in the homeostasis of the joint environment, but the relationship between the two still needs further confirmation. This study used a comprehensive analysis of two sample Mendelian randomization (MR) to explore the relationship between immune cell characteristics and the risk of RA.
Methods
Based on publicly available genetic data, the study used Mendelian randomization (MR) comprehensive analysis method to explore the causal relationship between 731 immune cell features and RA risk. To reduce data bias, we used GWAS data from two independent European populations of RA cohorts: the UK Biological Sample Library (Ncase = 1605Ncontrol = 359589) and the FinnGen database (Ncase = 4594Ncontrol = 214196) for MR analysis. Among them, we use the GWAS data of RA in the UK biological sample library as the "discovery queue data", and the GWAS data of RA in the FinnGen database as the "validation queue data". Then, we conduct MR analysis and meta-analysis separately. Use Cochran's Q test and MR Egger intercept test analysis to evaluate the heterogeneity, horizontal pleiotropy, and stability of SNPs in RA.
Result
We found that a total of 46 SNPs were associated with RA in 731 immune cell features and GWAS data from the UK biological sample library (P < 0.05), while 59 SNPs were associated with RA in the FinnGen database (P < 0.05). Subsequently, we performed meta-analysis on the two sets of data, and if the statistical heterogeneity was significant (I ²༞ 50%), using a random effects model; On the contrary, using a fixed effects model, six SNPs were found to be associated with rheumatoid arthritis (P < 0.05), including: CD39 + secretory CD4 regulatory T cell% secretory CD4 regulatory T cell (P = 0.0001, OR = 0.97, 95% CI: 0.9552–0.985), CD39 + secretory CD4 regulatory T cell% CD4 regulatory T cell (P = 0.0038, OR = 0.97, 95% CI: 0.9502–0.9902), CD39 + CD4 + T cell% T cell (P = 0.0093, OR = 0.98, 95% CI: 0.9652–0.995), CD3 on CD39 + resting CD4 regulatory T cell (P = 0.0411, OR = 0.93, 95% CI: 0.8674–0.9971), CD80 on myeloid Dental Cell (P = 0.0419, OR = 1.06, 95% CI: 1.0021–1.1212), HLA DR on CD33- HLA DR+(P < 0.0001, OR = 1.25, 95% CI: 1.118–1.3975).
Conclusion
We conducted MR analysis on GWAS data based on large-scale population studies to demonstrate a close relationship between immune cell characteristics and RA from a genetic perspective, which will provide scientific basis for further research on the pathogenesis and clinical treatment of RA.
Study of mechanical characteristics and microstructure on ZM21 alloy with Tricalcium Phosphate using Friction stir processing
Authors: Muzammiluddin Mohd , Thirumurugan M. 
Published: November 2023

Abstract

Friction stir processing (FSP) at 1120 rpm was performed to refine surface characteristics of a magnesium alloy which included tri-calcium phosphate. Hardness tests showed that measurements of average hardness and the hardness of the surface layer have been significantly altered by the dispersed nanoparticles. Due to the deposition of greater Ca/P mineral phase, the FSP ZM21 saw less weight loss than the unprocessed alloy during immersion test investigations conducted in simulated body fluids (SBFs) in 24 hours. As demonstrated by the results of the tensile testing, the FSP ZM21 alloy had a greater ultimate tensile strength than the parent alloy. Additionally, the tensile specimens were tested after being subjected to the corrosive medium SBF for 24 hours. Results indicate an enhanced effect of grain refinement, reduced intermetallic phase, and development of supersaturated grains on retaining the improved mechanical characteristics following degradation.
Nucleotide-Binding Oligomerization Domain 1 (NOD1) regulates microglia activation in Pseudorabies Virus Infection
Authors: Sun Xiuxiu , Jin Xinxin , Lin Zhengdan , Liu Xi , Yang Junjie , Li Li , Feng Helong , Zhang Wanpo , Gu Changqin , Hu Xueying , Liu Xiaoli , Cheng Guofu 
Published: November 2023

Abstract

The primary cause of viral encephalitis is the invasion of the central nervous system (CNS) by the virus, leading to neuroinflammation, which poses a significant threat to global public health. Microglia, as CNS-resident macrophages, play a crucial role in neuroinflammation and are often identified as the preferred target for the prevention or treatment of viral encephalitis. Nucleotide-binding oligomerization domain 1 (NOD1) is a pattern recognition receptor associated with various human inflammatory diseases. In this study, we used pseudorabies virus (PRV) as a model to investigate the regulation of microglial responses during viral encephalitis and explored whether NOD1 suppressed neuroinflammation by regulating microglial activation. Cellular experiments revealed microglia activation accompanied by cell migration, characteristic morphological changes, phagocytosis, inflammatory cytokine production, and antigen presentation. Subsequently, we studied the impact of NOD1 on PRV-induced microglia activation. Both in vitro and in vivo results demonstrated that PRV infection upregulated the mRNA and protein expression of NOD1. Modulation of NOD1 expression, either through inhibition or overexpression, resulted in a corresponding reduction or enhancement of the JNK and NF-κB signaling pathways, regulating microglial activation and the inflammatory response induced by PRV.
BACKGROUND
Viral encephalitis is an acute inflammatory process resulting from viral infections in the CNS. Microglia, as the primary effectors of inflammation in the CNS, play a crucial role. Notably, NOD1/RIP2 signalling is implicated in the initiation of inflammatory responses to viruses. Our study offers novel perspectives for developing protective strategies against neuroinflammation by elucidating the NOD1/RIP2-mediated regulation of microglia. Furthermore, it identifies NOD1 as a potential target for mitigating microglia hyperactivation.