bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global, regional, and national burden of gallbladder and biliary diseases from 1990 to 2019
Authors: Li Zhong-Zhuan , Guan Lin-Jing , Ouyang Rong , Chen Zhi-Xin , Ouyang Guo-Qing , Jiang Hai-Xing 
Published: November 2023

BACKGROUND
Gallbladder and biliary diseases (GABDs) are a major public health issue.
AIM
To analysis the cause-specific incidence, prevalence, and years lived with disability (YLDs) and its temporal trends of GABDs at the global, regional, and national level. Data on GABD were available from the Global Burden of Disease study 2019.
METHODS
The estimated annual percentage change (EAPC) was used to quantify temporal trend in GABD age-standardized incidence rates (ASIRs), age-standardized prevalence rate (ASPR), and age-standardized YLD rate (ASYR) by region, sex. We analyzed the relationship between the GABD burden and country development level using the human development index (HDI).
RESULTS
In 2019, the incident cases of GABD were 52003772, with an ASIR of 63432/100000 population. Globally, the number of incident cases and ASIR of GABD increased 97% and 58.9% between 1990 and 2019. Although, the ASPR and ASYR decreased from 1990 to 2019, the number of prevalent and YLDs cases increased. The highest ASIR was observed in Italy, and the highest ASPR and ASYR was observed in United Kingdom. The highest burden of GABD was found in low-SDI region, and the burden in female was significantly higher than males. A generally negative correlation (ρ = -0.24, P < 0.05) of GABD with the EAPC and human development index (HDI) (in 2021) were observed for ASIR. What’s more, no correlation in ASPR (ρ = -0.06, P = 0.39) and ASYR (ρ = -0.07, P = 0.36) of GABD with the EAPC and HDI (in 2021) were observed, respectively.
CONCLUSION
GABD remain a major global public health challenge; however, the burden of GABD varies geographically. Globally, the number of incident cases and ASIR of GABD increased between 1990 and 2019. The results of our study provide insight into the global disease burden of GABD and may assist policymakers in formulating effective policies to mitigate modifiable risk factors.
Watson İyileştirici Öz-Değerlendirme Ölçeği’ nin Türkçe Geçerlik ve Güvenirliği
Authors: BIDIK Gizem , ŞİŞMAN Fatma Nevin 
Published: November 2023

Amaç: Bu çalışmada amaç, Watson İyileştirici Öz-Değerlendirme Ölçeği’nin (WİÖÖ) Türkçe geçerlik, güvenirlik ve psikometrik özelliklerini belirlemektir.
Yöntem: Bu metodolojik araştırma, 2021-2022 eğitim öğretim yılında İstanbul’da bir devlet üniversitesinin hemşirelik öğrencileri ile yürütüldü (n=444). Türkçe’ ye uyarlama çalışması kapsamında ölçeğin dil uyarlaması çeviri-geri çeviri yöntemiyle yapıldı. Ölçeğin kapsam ve yapı geçerliği yapıldı. Güvenirlik çalışmasında Cronbach alfa katsayısı ve MacDonald’s Omega değerleri, test-tekrar test ve paralel form analizleri kullanıldı. Ekim-Kasım 2021 tarihinde 444 katılımcıdan toplanan veriler, test-tekrar test yöntemi için bu katılımcılar arasından seçilen 80 kişiden Ocak-Şubat 2022 tarihinde tekrar toplandı.
Bulgular: Katılımcıların yaş ortalaması 20.29±2.32’tür. Ölçeğin kapsam geçerlik indeksi ortalama 3.65 ve % 91.36 olarak belirlendi. Doğrulayıcı faktör analizinde uyum indekslerinin yeterli uyum gösterdiği görüldü. Beş madde ve tek alt boyuttan oluşan yapı doğrulandı. Ölçeğin toplam Cronbach alfa değeri 0.84, MacDonald’s Omega Değeri 0.84 olarak bulundu. Paralel form güvenirliğinde, WİÖÖ puanları ile Öz Anlayış Ölçeği (ÖAÖ), Kısa Psikolojik Sağlamlık Ölçeği (KPSÖ) ve Sağlığı Geliştirici ve Koruyucu Davranışlar Ölçeği (SGKDÖ) puanları arasında orta düzeyde pozitif yönde ilişki saptandı. Ölçeğin test-tekrar test analizinde kullanılan Sınıf İçi Korelasyon Katsayısı (ICC) 0.75 olarak belirlendi (p
PENGEMBANGAN APLIKASI PERHITUNGAN BAHAN BAKAR UNTUK OPERASIONAL KAPAL BERBASIS ANDROID
Authors: Retno Gunarti Monika , Dwi Suharso Didik , Purnomo Hendra , Zainudin Muhamad , Esayadi Alvin 
Published: November 2023

Penelitian ini bertujuan untuk mengembangkan aplikasi berbasis android untuk menghitung jumlah bahan bakar disesuaikan dengan jarak tempuh dan kecepatan kapal berdasarkan lintasan yang dilalui (way point). Perhitungan jarak dalam pengembangan aplikasi menggunakan metode sperichal triangle yang digunakan dalam navigasi pelayaran. Pengembangan aplikasi ini mengadopsi model waterfall dengan tahapan Requirement Engineering (Analisis kebutuhan), design and implementation (desain dan implementasi), Testing (Pengujian dan integrasi), Release (hasil akhir dan pelepasan produk) dan Maintenance (perawatan). Review produk pengembangan melibatkan ahli perangkat lunak untuk memberikan kritik dan saran. Pengembangan ini diuji dengan perhitungan manual dan dibandingkan dengan ECDIS (electronic Chart Display Information System). Hasil pengujian menunjukkan tidak ada perbedaan yang signifikan antara hasil perhitungan menggunakan aplikasi dengan perhitungan manual maupun ECDIS, karena perhitungan jarak dan bahan bakar memiliki selisih yang sangat kecil.
Türkiye'de Enerji Şifacılığı Üzerine Bir Araştırma
Authors: DOĞAN KOÇAK Burcu 
Published: November 2023

Öz
Bu çalışmada, farklı inançların, kadim öğretilerin, geleneksel yöntemlerin, çeşitli felsefi düşüncelerin ve uygulamaların senkretik ve eklektik bir biçimde harmanlanmasından oluşan Yeni Çağ İnanışlarının öne çıkan unsurlarından enerji şifacılığının, Türkiye'de kimler tarafından neden ilgi gördüğü, enerji şifacılığının kendi içinde inşa ettiği karakteristik yapının ne olduğu ortaya koyulmaya çalışılmıştır. Araştırmanın temel ereği meslek olarak şifacılığı seçmiş kişilerin sosyal, demografik konumlarını anlamak ve onları bu alana yönlendiren süreçleri ve motivasyonlarını değerlendirmektir. Nitel araştırma yöntemlerinden fenomenoloji ile derinlemesine mülakat ve katılımlı gözlem tekniklerinden yararlanılarak, amaçsal örneklemle belirlenen 6’sı kadın, 4’ü erkek, 10 katılımcı ile veri doygunluğuna ulaşılıncaya kadar Mayıs 2022 ve Nisan 2023 tarihleri arasında görüşmeler yapılmıştır. Şifa ile ilgili katılımcılara açık uçlu sorular sorulmuş ve verilen cevaplar analiz edilmiştir. Katılımcıları hepsi 40 yaş üzeri, iyi eğitimli, orta-üst gelir grubundan, inançlı, çoğunlukla beyaz yakalı profesyonel mesleklerini bırakarak şifacılığı seçmiş kişilerdir. Katılımcılar, iyileşmenin sadece fiziksel sağlıkla sınırlı olmadığını, aynı zamanda duygusal, zihinsel ve ruhsal boyutları da içerdiğine vurgu yapmışlardır. İyileşme süresinde çağdaş tıp yöntemlerinin yanı sıra geleneksel, alternatif, tamamlayıcı ve ruhani yaklaşımların da etkili olduğuna inanılmakta ve katılımcıların bu yöndeki görüşleri ön plana çıkmaktadır.

Anahtar Kelimeler: Yeni Çağ İnanışları, Şifalanma, Enerji Şifası, Şifacı
How do weather risks in Canada and the United States affect global commodity prices? Implications for the decarbonisation process
Authors: Lau Chi Keung , Cai Yifei , Gozgor Giray 
Published: November 2023

AbstractGiven that the probability of extreme weather has been dramatically increasing, this study contributes to the existing literature by bridging the relation between weather risks and global commodity prices with a secondary dataset (e.g., weather risks of Canada and the United States, agricultural raw materials price, gold price, and crude oil price). The results from the vector autoregression model and impulse response functions show that rising weather risks increase the price of agricultural raw materials and gold. However, the negative impact of weather risks on the crude oil price is found. Finally, the paper discusses the findings' potential implications (e.g., developing decarbonised supply chains) for decreasing weather risks' effects on commodity market uncertainties.
Effect of Aromatic Rings in AESO-VDM Biopolymers on the Local Free Volume and Diffusion Properties of Polymer Matrix
Authors: Královič David Pavel , Cifraničová Katarína , Švajdlenková Helena , Tóthová Darina , Šauša Ondrej , Kalinay Pavol , Kavetskyy Taras , Ostrauskaite Jolita , Smutok Oleh , Gonchar Mykhailo , Soloviev Vladimir , Kiv Arnold 
Published: November 2023

AbstractIn this work, the influence of aromatic rings on the local free volume of cured mixtures of acrylate epoxidized soybean oil (AESO) and vanillin dimethacrylate (VDM) was investigated. Cross-linking took place under the influence of UV light in the presence or absence of a photoinitiator. The local free volume and its homogeneity were characterized using the Positron Annihilation Lifetime Spectroscopy (PALS) technique. It was found that increasing the content of VDM, which contains aromatic rings, caused a decrease in the local free volume of the cured polymer network, with consequences for the diffusion properties of the polymer, which were tested for the case of water. Another consequence of increasing the content of VDM was a decrease in the conversion of double bonds in the finally cured samples, characterized by near-infrared spectroscopy (NIR). This finding illustrates a case where the decrease in free volume is not necessarily related to an increase in the crosslinking density of the polymer, but is a consequence of the presence of an increase in the occupied volume of aromatic rings in the volume of the polymer.
Strictly positive definite non-isotropic kernels on two-point homogeneous manifolds: the asymptotic approach
Authors: Guella J. C. , Jäger J. 
Published: November 2023

AbstractWe present sufficient conditions for a family of positive definite kernels on a compact two-point homogeneous space to be strictly positive definite based on their expansion in eigenfunctions of the Laplace–Beltrami operator. We also present a characterisation of this kernel class. The family analyzed is a generalization of the isotropic kernels and the case of a real sphere is analyzed in details.
An investigation of the applicability of contact models to the normal load-deformation behaviour of artificially shaped granite
Authors: Altuhafi F. , Baudet B. A. , Coop M. R. 
Published: November 2023

AbstractThe validity of different available contact models is tested against experimental data for contact normal loading of artificially shaped granite stones. Three elastic models and two plastic models were tested with different combinations of contact shape (spherical, conical and flat) and roughnesses. It was found that the deviation from the Hertz model increased with surface roughness with a generally better representation of the data achieved by using models which consider surface roughness and the fractality of the surface. The validity of all these models seems to be limited to before excessive plastic deformations start taking place, after which the contact seems to deform under constant stiffness.
Impact of industrial robots on environmental pollution: evidence from China
Authors: Liu Yanfang 
Published: November 2023

AbstractThe application of industrial robots is considered a significant factor affecting environmental pollution. Selecting industrial wastewater discharge, industrial SO2 emissions and industrial soot emissions as the evaluation indicators of environmental pollution, this paper uses the panel data model and mediation effect model to empirically examine the impact of industrial robots on environmental pollution and its mechanisms. The conclusions are as follows: (1) Industrial robots can significantly reduce environmental pollution. (2) Industrial robots can reduce environmental pollution by improving the level of green technology innovation and optimizing the structure of employment skills. (3) With the increase in emissions of industrial wastewater, industrial SO2, and industrial dust, the impacts generated by industrial robots are exhibiting trends of a “W” shape, gradual intensification, and progressive weakening. (4) Regarding regional heterogeneity, industrial robots in the eastern region have the greatest negative impact on environmental pollution, followed by the central region, and the western region has the least negative impact on environmental pollution. Regarding time heterogeneity, the emission reduction effect of industrial robots after 2013 is greater than that before 2013. Based on the above conclusions, this paper suggests that the Chinese government and enterprises should increase investment in the robot industry. Using industrial robots to drive innovation in green technology and optimize employment skill structures, reducing environmental pollution.
FT-Raman data analyzed by multivariate and machine learning as a new methods for detection spectroscopy marker of platinum-resistant women suffering from ovarian cancer
Authors: Kluz-Barłowska Marta , Kluz Tomasz , Paja Wiesław , Sarzyński Jaromir , Łączyńska-Madera Monika , Odrzywolski Adrian , Król Paweł , Cebulski Józef , Depciuch Joanna 
Published: November 2023

AbstractThe phenomenon of platinum resistance is a very serious problem in the treatment of ovarian cancer. Unfortunately, no molecular, genetic marker that could be used in assigning women suffering from ovarian cancer to the platinum-resistant or platinum-sensitive group has been discovered so far. Therefore, in this study, for the first time, we used FT-Raman spectroscopy to determine chemical differences and chemical markers presented in serum, which could be used to differentiate platinum-resistant and platinum-sensitive women. The result obtained showed that in the serum collected from platinum-resistant women, a significant increase of chemical compounds was observed in comparison with the serum collected from platinum-sensitive woman. Moreover, a decrease in the ratio between amides vibrations and shifts of peaks, respectively, corresponding to C–C/C–N stretching vibrations from proteins, amide III, amide II, C = O and CH lipids vibrations suggested that in these compounds, structural changes occurred. The Principal Component Analysis (PCA) showed that using FT-Raman range, where the above-mentioned functional groups were present, it was possible to differentiate the serum collected from both analyzed groups. Moreover, C5.0 decision tree clearly showed that Raman shifts at 1224 cm−1 and 2713 cm−1 could be used as a marker of platinum resistance. Importantly, machine learning methods showed that the accuracy, sensitivity and specificity of the FT-Raman spectroscopy were from 95 to 100%.
Identifying phenotype-associated subpopulations through LP_SGL
Authors: Li Juntao , Zhang Hongmei , Mu Bingyu , Zuo Hongliang , Zhou Kanglei 
Published: November 2023

Abstract
Single-cell RNA sequencing (scRNA-seq) enables the resolution of cellular heterogeneity in diseases and facilitates the identification of novel cell types and subtypes. However, the grouping effects caused by cell–cell interactions are often overlooked in the development of tools for identifying subpopulations. We proposed LP_SGL which incorporates cell group structure to identify phenotype-associated subpopulations by integrating scRNA-seq, bulk expression and bulk phenotype data. Cell groups from scRNA-seq data were obtained by the Leiden algorithm, which facilitates the identification of subpopulations and improves model robustness. LP_SGL identified a higher percentage of cancer cells, T cells and tumor-associated cells than Scissor and scAB on lung adenocarcinoma diagnosis, melanoma drug response and liver cancer survival datasets, respectively. Biological analysis on three original datasets and four independent external validation sets demonstrated that the signaling genes of this cell subset can predict cancer, immunotherapy and survival.
Understandings of Happiness and Life Satisfaction Among Refugees in the UK
Authors: Pollenne Daisy 
Published: November 2023

Abstract
Both qualitative and quantitative research draw increasingly on measures of life satisfaction and happiness to evaluate how refugees are faring in countries where asylum is obtained. However, existing evidence is limited, in that these two subjective well-being (SWB) measures are included in research as either interchangeable or distinct components of SWB. After conducting in-depth interviews with refugees based in the UK, this article presents three important contributions. First, life satisfaction is considered by refugees as a global assessment of key domains in their lives. Second, refugees define happiness not only as an emotion but also as a personal disposition towards experiencing emotions positively. Third, there is a complex relational conditionality between these two components of SWB. While individual socio-demographics and experiences, including those of seeking asylum, bring nuances to the findings, these have significant implications for measuring refugees’ SWB in the UK and in post-displacement contexts more broadly.
Familial nonmedullary thyroid cancer: a case series in Iranian patients with a meta-review of case series
Authors: Mohammadi Zaniani Zohreh , Zeinalian Mehrdad , Tabatabaiefar Mohammad Amin 
Published: November 2023

Abstract

Background
Nonmedullary thyroid cancer (NMTC) comprises approximately 90% of all thyroid cancers, and about 3% to 9% of NMTC cases have a familial origin. Familial NMTC (FNMTC) in the absence of a documented familial cancer syndrome such as Cowden syndrome is characterized by the occurrence of thyroid cancer of follicular cell origin in 2 or more first-degree relatives.

Methods
Whole-exome sequencing (WES) was used to identify pathogenic genetic variants in 2 Persian families with FNMTC. The purpose of this work is to assess the pathogenic status of these variants as well as the cosegregation status of the variants observed in the examined families.

Results
By analyzing WES data in the first family, SRGAP1: NM_020762: exon16: c.C1849T was identified as a pathogenic variant. This variant was confirmed by Sanger sequencing. In the second family, the variant FOXE1: NM_004473: exon1: c.531_532insCGCGA was identified but was not confirmed by Sanger sequencing.

Conclusion
Based on the data, SRGAP1 can be a potential candidate gene for susceptibility to FNMTC in the first family. However, additional analyses like whole genome sequencing and copy number variations are required to ascertain the disease status in second family.
Dietary nitrate, nitrite, and nitrosamine in association with diabetes: a systematic review and meta-analysis
Authors: Nguyen Nam N , Tran Linh T D , Ho Ngan D K , Huynh Linh B P , Nguyen Hung S , Chen Yang-Ching 
Published: November 2023

Abstract

Context
Diabetes is a global health concern, and diet is a contributing factor to diabetes. Findings regarding the connection between nitrate, nitrite, and nitrosamine and diabetes risk are inconsistent.

Objective
The aim was to examine the effects of these dietary compounds on diabetes risk.

Data Sources
The data were sourced from PubMed, EMBASE, Scopus, and Web of Science until February 28, 2023. Studies that reported individual-level consumption of these compounds were included. Review articles or ecological studies were excluded.

Data Extraction
The number of events and total observations were recorded.

Data Analysis
The pooled odds ratio (OR) was calculated and displayed in a forest plot. Subgroup and sensitivity analyses were predefined. A dose–response meta-analysis was conducted to determine the exposure intervals that may increase the risk of disease. Six observational reports that met the inclusion criteria were included, involving 108 615 individuals. Participants in the highest quantile of nitrite intake had a greater risk of diabetes compared with those in the lowest quantile (OR, 1.61; 95% confidence interval [CI], 1.08–2.39; I2 = 74%, P = 0.02). Higher nitrosamine consumption tended to increase diabetes risk (OR, 1.52; 95% CI, 0.76–3.04; I2 = 76%; P = 0.24). The relationship was stronger for type 1 (OR, 1.79; 95% CI, 1.20–2.67; I2 = 58%; P &lt; 0.01) than for type 2 diabetes (OR, 1.42; 95% CI, 0.86–2.37; I2 = 71%; P = 0.17). Additionally, nitrite consumption had a dose-dependent association with both phenotypes. No association was found between diabetes risk and high nitrate intake (OR, 1.01; 95% CI, 0.87–1.18; I2 = 28%; P = 0.87).

Conclusion
Attention should be paid to the consumption of nitrite-containing foods.

Systematic Review Registration
PROSPERO registration no. CRD42023394462 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=394462).
Disease Progression Patterns of Brain Morphology in Schizophrenia: More Progressed Stages in Treatment Resistance
Authors: Sone Daichi , Young Alexandra , Shinagawa Shunichiro , Tsugawa Sakiko , Iwata Yusuke , Tarumi Ryosuke , Ogyu Kamiyu , Honda Shiori , Ochi Ryo , Matsushita Karin , Ueno Fumihiko , Hondo Nobuaki , Koreki Akihiro , Torres-Carmona Edgardo , Mar Wanna , Chan Nathan , Koizumi Teruki , Kato Hideo , Kusudo Keisuke , de Luca Vincenzo , Gerretsen Philip , Remington Gary , Onaya Mitsumoto , Noda Yoshihiro , Uchida Hiroyuki , Mimura Masaru , Shigeta Masahiro , Graff-Guerrero Ariel , Nakajima Shinichiro 
Published: November 2023

Abstract

Background and Hypothesis
Given the heterogeneity and possible disease progression in schizophrenia, identifying the neurobiological subtypes and progression patterns in each patient may lead to novel biomarkers. Here, we adopted data-driven machine-learning techniques to identify the progression patterns of brain morphological changes in schizophrenia and investigate the association with treatment resistance.

Study Design
In this cross-sectional multicenter study, we included 177 patients with schizophrenia, characterized by treatment response or resistance, with 3D T1-weighted magnetic resonance imaging. Cortical thickness and subcortical volumes calculated by FreeSurfer were converted into z scores using 73 healthy controls data. The Subtype and Stage Inference (SuStaIn) algorithm was used for unsupervised machine-learning analysis.

Study Results
SuStaIn identified 3 different subtypes: (1) subcortical volume reduction (SC) type (73 patients), in which volume reduction of subcortical structures occurs first and moderate cortical thinning follows, (2) globus pallidus hypertrophy and cortical thinning (GP-CX) type (42 patients), in which globus pallidus hypertrophy initially occurs followed by progressive cortical thinning, and (3) cortical thinning (pure CX) type (39 patients), in which thinning of the insular and lateral temporal lobe cortices primarily happens. The remaining 23 patients were assigned to baseline stage of progression (no change). SuStaIn also found 84 stages of progression, and treatment-resistant schizophrenia showed significantly more progressed stages than treatment-responsive cases (P = .001). The GP-CX type presented earlier stages than the pure CX type (P = .009).

Conclusions
The brain morphological progressions in schizophrenia can be classified into 3 subtypes, and treatment resistance was associated with more progressed stages, which may suggest a novel biomarker.