bluuebunny/crossref_metadata_2025_split huggingface dataset:
ARGUIÇÃO DA PREVALÊNCIA DOS CASOS DE HIPERTENSÃO ARTERIAL SISTÊMICA NO BRASIL DE JANEIRO DE 2022 A SETEMBRO DE 2023 E O EXERCÍCIO FÍSICO COMO MITIGADOR DA PATOLOGIA
Authors: De Oliveira Alves Guimarães Henrique , Fernandes de Morais Neto Joaquim , Carvalho de Aguiar Guilherme Elias 
Published: December 2023

Introdução: Hipertensão arterial sistêmica (HAS) é uma condição onde os níveis pressóricos estão continuadamente elevados, produzindo de forma consistente lesão das artérias de grande, médio e pequeno calibre, bem como lesão do coração de diversas formas e de outros órgãos nobres como cérebro e rins. Objetivos: o artigo tem como objetivo realizar uma arguição epidemiológica da HAS no Brasil de janeiro de 2022 a setembro de 2023. Metodologia: É um estudo epidemiológico de natureza descritiva, realizado por meio da coleta de dados anuais disponibilizado pelo Sistema de Internação Hospitalar (SIH), referentes ao período entre o mês de janeiro de 2022 a setembro de 2023 , no Brasil. As informações coletadas foram do número total de casos confirmados de Hipertensão Arterial Sistêmica Resultados: Identificou-se um total de 67920 casos confirmados, com maior incidência em mulheres, em pardos e em pessoas na faixa etária de 60 a 69 anos. O Sudeste foi a região com maior Taxa de Mortalidade. Conclusão: A HAS é uma doença não tem cura , entretanto com o tratamento adequado, o paciente pode manter a qualidade de vida.
Palavras-chave: Hipertensão. Pressão. Epidemiologia
EPIDEMIOLOGIA DOS CASOS DE HANSENÍASE EM MENORES DE 15 ANOS, NOTIFICADOS EM PALMAS-TOCANTINS, REFERENTES AO BIÊNIO 2021-2022.
Authors: Pereira Castro Camilo Ana Beatriz , Alves de Castro Neto Antônio , Medeiros de Melo Rycharles Rudson 
Published: December 2023

INTRODUÇÃO: Define-se hanseníase como doença infectocontagiosa causada pelo bacilo Mycobacterium leprae. De evolução lenta, se manifesta, principalmente, por meio de sinais e sintomas dermatoneurológicos, como lesões dérmicas e nos nervos periféricos, com maior incidência nos olhos, mãos e pés. É considerada de alta infectividade e baixa patogenicidade - infecta várias pessoas, porém poucas adoecem, atingindo ambos os sexos e todas as idades, porém, raramente, em crianças. A incidência em menores de 15 anos está relacionada com uma maior endemicidade da micobacteriose. METODOLOGIA: Estudo longitudinal descritivo, quantitativo e analítico, por meio da análise secundária do banco de dados do DATASUS e do SINAN, sendo a população delimitada pela quantidade de casos de hanseníase em menores de 15 anos, notificados ao SUS, em Palmas - Tocantins, referentes ao biênio 2021-2022. RESULTADOS: Foram registrados 29 casos de hanseníase em menores de 15 anos, em Palmas - Tocantins, prevalecendo no sexo feminino. A forma clínica predominante na faixa etária analisada é a dimorfa, representada por 21 ocorrências. Já em relação à evolução do caso, tem-se, com maior frequência, o não preenchimento dos dados. CONCLUSÃO: A presença da Moléstis de Hansen em crianças indica a presença de um contactante multibacilar próximo e frequente, sendo necessária a investigação do contexto familiar e/ou domiciliar. É uma doença curável e quanto mais precoce o diagnóstico e tratamento, sendo a terapêutica feita corretamente, mais rápida é a evolução para a cura, prevenindo também as incapacidades e deformidades, pois a poliquimioterapia torna o bacilo inviável desde o início do tratamento.
NILAI PH DAN TOTAL ASAM LAKTAT SUSU PASTEURISASI DENGAN PENAMBAHAN EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten) Steenis) SELAMA PENYIMPANAN
Authors: Maryana Dwi , Suriani Suriani , Wahab Ali Akbar , Maruddin Fatma , Malaka Ratmawati 
Published: December 2023

The utilization of Binahong leaf extract in pasteurized milk is an alternative to maintain the quality of pasteurized milk. The research objective was to determine the quality of pasteurized milk with the addition of binahong leaf extract and different storage times for pH values and lactic acid content. This study used a completely randomized design (CRD) factorial pattern with 2 (two) factors. The first factor (A) is the concentration of Binahong leaf extract (0%, 4%, 5%, 6%) and the second factor (B) is storage time (0 days, 3 days, 6 days, 9 days) of each the treatment, repeated 3 times. The results showed that the concentration of Binahong leaf extract, interaction time, and interaction had a very significant effect on the pH value of pasteurized milk. The effect of Binahong leaf extract and storage time had a significant effect on lactic acid content, but the interaction between the two treatments had no significant effect. The conclusion of this research is that the higher the concentration of Binahong leaf extract, the pH value decreases, and the lactic acid content of pasteurized milk increases. The longer the storage decreased the pH value, but increased the lactic acid content of pasteurized milk. The concentration of Binahong leaf extract 0-6% and storage time of 6 days still has good pasteurized milk quality.
Efficiency of eSource Direct Data Capture in Investigator-Initiated Clinical Trials in Oncology
Authors: YAEGASHI Hiroko , HAYASHI Yukikazu , TAKEDA Makoto , CHIU Shih-Wei , NAKAYAMA Haruhiko , ITO Hiroyuki , TAKANO Atsushi , TSUBOI Masahiro , TERAMOTO Koji , SUZUKI Hiroyuki , KATO Tatsuya , YASUI Hiroshi , NAGAMURA Fumitaka , DAIGO Yataro , Yamaguchi Takuhiro 
Published: December 2023

Abstract
Background
Clinical trials have become larger and more complex. Thus, eSource should be used to enhance efficiency. This study aimed to investigate the impact of using direct data capture (eSource DDC) using electronic case report forms as source data on the efficiency of a late-phase, multicenter, investigator-initiated clinical trial in oncology.
Methods
Source data identification list, electronic data capture (EDC) database structure specifications, audit trails output from EDC, and monitoring reports were used to analyze varying collection items of DDC at each site, time from data occurrence to data entry and data finalization, and number of visits to the site and time spent at the site by clinical research associates (CRAs). Additionally, simulations were performed on the change in hours at the clinical sites during the implementation of eSource DDC.
Results
The percentage of fields with DDC was 61.9–84.5%, indicating variations across sites. The forms commonly defined as DDC for all sites tended to be initially entered by clinical research coordinators. No difference in time from data occurrence to data entry was observed between the DDC and the transcribed data fields. However, the DDC fields could be finalized 4 days earlier than the non-DDC fields. Additionally, although no difference was observed in the number of visits for source data verification (SDV) by CRAs, a comparison between sites that introduced eSource DDC and those that did not showed that the time spent at the site for SDV was reduced. Furthermore, the simulation results indicated that even a small amount of data to be collected or a small percentage of DDC-capable items may lead to greater efficiency when the number of subjects per site is significant.
Conclusions
The implementation of eSource DDC may enhance efficiency, depending on the study framework and the type and number of items to be collected.
Exploring the Roles of Ribosomal Peptides in Prokaryote-Phage Interactions through Deep Learning-Enabled Metagenome Mining
Authors: Gao Ying , Zhong Zheng , Zhang Dengwei , Zhang Jian , Li Yong-Xin 
Published: December 2023

Abstract
Background
Microbial secondary metabolites play a crucial role in the intricate interactions within the natural environment. Amongst these metabolites, ribosomally synthesized and post-translationally modified peptides (RiPPs) are becoming a promising source of therapeutic agents due to their structural diversity and functional versatility. However, their biosynthetic capacity and ecological functions remain largely underexplored.
Results
Here, we aim to explore the biosynthetic profile of RiPPs and their potential roles in the interactions between microbes and viruses in the ocean, which encompasses a vast diversity of unique biomes that are rich in interactions and remain chemically underexplored. We first develop TrRiPP to identify RiPPs from ocean metagenomes, a deep learning method that detects RiPP precursors in a hallmark gene-independent manner to overcome the limitations of classic methods in processing highly fragmented metagenomic data. Applying this method to metagenomes from the global ocean microbiome, we uncover a diverse array of previously uncharacterized RiPP families with great novelty and diversity. Through correlation analysis based on multi-omics data, we observe a high prevalence of antiphage defense-related and phage-related protein families that co-occurred or co-expressed with RiPP families. Based on this putative association between RiPPs and phage infection, we constructed an Ocean Virus Database (OVD) and established a RiPP-involving host-phage interaction network through host prediction and co-expression analysis, revealing complex connectivities linking RiPP-encoding prokaryotes, RiPP families, viral protein families, and phages. These findings highlight the potential of RiPP families involved in prokaryote-phage interactions and coevolution, providing insights into their ecological functions in the ocean microbiome.
Conclusions
This study provides a systematic investigation of the biosynthetic potential of RiPPs from the ocean microbiome at a global scale, shedding light on the essential insights into the ecological functions of RiPPs in prokaryote-phage interactions through the integration of deep learning approaches, multi-omics data, and host-phage connectivity. This study serves as a valuable example of exploring the ecological functions of bacterial secondary metabolites, particularly their associations with unexplored microbial interactions.
Photochemical Upcycling of Ultrastrong Polyethylene Nanomembranes into Fibrous Carbon at Ambient Conditions
Authors: Gao Ping , SUN Yuexiang , Ma Xin , Gu Qiao 
Published: December 2023

Abstract
The escalating global issue of plastic waste accumulation, specifically polyolefins, necessitates an urgent solution for upcycling these materials into beneficial compounds. Yet, achieving such upcycling without introducing carbon dioxide into the environment remains a formidable challenge. In this study, we demonstrate an eco-friendly approach for the photochemical conversion of ultrastrong, ultratransparent, and ultrathin polyethylene membrane into fibrous carbon nanomembrane at ambient conditions. The membrane was sputter-coated with platinum and cuprous oxide nanoparticles and exposed to simulated sunlight, resulting in a porous carbon membrane decorated with Pt nanoparticles. The new carbonized nanomembrane maintained the pristine membrane's morphology. The membrane exhibited high activity (2.11 mA/cm2) for electrochemical ethanol oxidation with stability over 1000 cycles. This work holds significance for sustainable plastic waste management and the design of new polyolefin materials in a circular economy.
Is there an association between COVID-19 infection and fetuses with mirror-image dextrocardia?
Authors: Wenjiao Xu , Wei Yajuan , Huo Huanhuan , Zhao Enfa , Liu Baomin 
Published: December 2023

Abstract
I am excited to write a letter to share our findings.Coronavirus disease (COVID-19) is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the family of severe acute respiratory syndrome coronaviruses [1]. On December 7, 2022, the Chinese government lifted the restrictions on controlling the COVID-19 pandemic, which resulted in an explosive increase in the SARS-CoV-2 infection rate among the Chinese population. The self-reported infection rate, as determined from an online survey, reached its peak (15.5%) between December 19 and 21, 2022, with an estimated 82.4% of individuals in China being infected as of February 7, 2023 [2]. Mirror-image dextrocardia is rare, with varying incidence among studies and countries. According to the literature, the incidence ranges from 1/8,000 to 2,0000[3]. In our recent routine prenatal screening of fetuses, we found 4 cases of fetal mirror dextrocardia within just one month. And The last menstrual period of these pregnant women was in November 2022. Is there an association between COVID-19 infection and fetuses with mirror-image dextrocardia? Therefore, we conducted an epidemiological investigation to analyze the incidence of mirror-image dextrocardia in pregnant women and fetuses before and after the lifting of coronavirus disease (COVID-19) control measures in China on December 7, 2022.
Implication of Fault Seal Analysis Method to Evaluate the Sealing Conditions of Major Fault Planes at Barapukuria Basin, North-West Bangladesh
Authors: Roy Sushanta Kumar , Shemu Tamanna Meheran , Alam Mohammad Jahangir 
Published: December 2023

Abstract

The Barapukuria Coal Mine is Bangladesh's first and only producing coal mine. The basin is characterized by two major faults that encompass the basin's periphery, as well as multiple minor faults and mine-induced reactivation faults. An extensive Upper Dupitila aquifer and Gondwana Upper Sandstone aquifer are the probable sources of inundation. This study focuses on determining the unsealed faults that can create a potential threat of water leakage in the mine area based on the superposition of lithological sequences, aquifer properties, and sealing capacity of the fault plane using the fault seal analysis method. The superposition of lithological sequences proposed that the northern portion of the study area is more vulnerable to underground inundation due to the presence of very thin or no impermeable layers between the upper UDT aquifer and the underlain Gondwana formation. The fault seal analysis, reveals that the SGR values for the largest Eastern Boundary Fault were estimated to be 0.08 and 0.13; 0.05 for the second largest fault FB; 0.35 and 0.53 for the fault FB-1; and 5.65, 1.69, and 1.22 for the three smaller faults, BGP-N-F11, BGP-N-F2, and F-24. According to Yielding et al classifications of fault sealing, these SGR value represents that the largest Eastern Boundary and the FB fault dip to the west and have an angle of dip of 750-800, indicating that they are susceptible to inundation. An incident of underground flooding along the FB fault plane was reported in 1998, which resembled the study's outcomes.
Identification of SSR markers linked to the abscission of cotton bolls traits and mining germplasm in Cotton
Authors: Guangling SHUI , Hairong LIN , Xiaomei MA , Bo ZHU , Peng HAN , Aini Nurimanguli , Chunping GUO , Yuanlong WU , Zhenyuan PAN , Chunyuan YOU , Guoli SONG , Nie Xinhui 
Published: December 2023

Abstract
Background: Cotton is one of the most important economic crops. To effectively improve yield of cotton, an urgent way is decreasing the abscission of cotton bolls and buds. However, unclear genetic and molecular mechanism underlying cotton bolls abscission traits hindered the genetic improvement of cotton.
Methods: In this study, the correlation analysis between abscission traits and other agronomically important traits were carried out by Pearson correlation analysis. Then, a genome-wide association study for these traits were performed based on 145 alleles locus with highly polymorphism and uniformly distributed on 26 chromosomes by TASSEL V2.1 software. The loci of elite allelic variation and typical materials carrying elite alleles were determined by association study.
Results: The Pearson correlation analysis showed a significant positive correlation among AR1 (boll abscission rate 1) and AR2 (boll abscission rate 2). There were 18, 46 and 62 markers significantly associated with abscission traits, fiber quality traits and yield traits (P < 0.05), and explaining 1.75% ~ 7.13%, 1.16% ~ 9.58% and 1.40% ~ 5.44% of the phenotypic variation respectively. Among these markers, MON_CGR5732aand MON_CGR5732b markers were associated with cotton abscission traits, fiber quality traits and yield traits loci, and 13 marker loci have been reported by previous studies. In addition, based on phenotypic effects six typical materials with elite allele loci related to fiber quality traits were identified and they will be widely used in practical breeding.
Conclusions: Phenotypic analysis of 238 accessions showed that the traits were relatively stable under four environmental conditions, and AR2 was an important indicator of abscission. Association analysis based on SSR markers provides two excellent allelic variants associated with low abscission rate and the six typical materials with excellent alleles.
Translating electrophysiological signatures of awareness into thalamocortical mechanisms by inverting systems-level computational models across arousal states
Authors: Medel Vicente , Shine James , Munn Brandon , Muller Eli , Casey Cameron , Sanders Robert 
Published: December 2023

Abstract
While consciousness never fades during wakefulness, there is a paradoxical coexistence of consciousness during dreaming states. It’s also possible for sensory awareness to be either present or absent when awakened from seemingly-identical states of sedation and anaesthesia. Traditionally, these states have been characterised in terms of their electroencephalographic neural correlates, however, without clear underlying neurobiological mechanisms. To bridge this gap, we invert a validated neural mass model of the corticothalamic system using scalp EEG collected during nonlinear transitions in conscious experience and sensory awareness across varying depths of dexmedetomidine sedation. We found that a decline in conscious experience and sensory awareness with dexmedetomidine was associated with a decrease in the engagement of excitatory thalamocortical loop resonances, along with an increase in inhibitory intrathalamic loop gains. These findings shed light into the neural mechanisms of conscious experience and sensory awareness, and explain how it fades across arousal states, bridging the gap between the neural correlates of consciousness and its underlying systems-level thalamocortical mechanisms.
Three-dimensional dynamic analytical modeling and vibration analysis of deep groove ball bearings under multi-source internal fault excitation
Authors: Luo Yang , Hu Jimin , Shi Juanjuan , Yu Yihao , Baddour Natalie , wang Jun , Shen Changqing , Huang Weiguo 
Published: December 2023

Abstract
Dynamic modeling can greatly inform the study of characteristics of bearing failures. However, traditional two-dimensional dynamic models are not effective in analyzing complex dynamic characteristics of bearing elements, in particular three-dimensional rotations, gyroscopic effects, and lubrication traction under high-speed operations. To address these limitations, this paper establishes a novel three-dimensional bearing dynamic analytical model based on Hertz contact theory. The proposed model considers multiple rigid body degrees of freedom, rotational attitude, dynamic circular motion, and mixed elastic lubrication of the bearings. Dynamic variation of the contact points between bearing elements are described using quaternions. The proposed model is validated by experiments. By introducing a contact stiffness variation coefficient, this paper also demonstrates that replacing time-varying Hertz contact stiffness with a constant Hertz contact stiffness produces insignificant errors in the localized fault region. To further test the effectiveness of the proposed three-dimensional model, Lempel-Ziv complexity (LZC) is adopted. The LZC values of the signals from the three-dimensional model, two-dimensional model and experiment are compared. It is found that the LZC of the three-dimensional model signal is closer to that of the experimental signal, indicating that the proposed model can more accurately reflect actual bearing operations.
Muted community and “loudly” land use: participatory mapping to explore the niche construction in a matrilineal community under market integration (MI), southwest China.
Authors: Liu Ruizhe 
Published: December 2023

Abstract
This participatory mapping study explores the niche construction process in the Mosuo community of Southwest China in response to market integration (MI). By using participatory methods, the study ensures that insights gained are grounded in the local cultural context and that community perspectives are central to the analysis. Two streets in the lower Mosuo community represent distinct approaches to niche construction: Street A focuses on the natural beauty and ecology of the lake, while Street B promotes Mosuo cultural identity and heritage. The distribution of stores on each street offers insights into economic and social dynamics, revealing that Street B prioritizes local community needs alongside those of visitors, while Street A relies more on tourism traffic. The study also shows how the Mosuo people have adapted to MI through changes in occupational patterns, living spaces, and population movement. MI has led to a transformation of social norms, with the younger generation more attracted to foreign cultures and the older generation resisting to protect their traditional culture. Additionally, the study highlights a disparity between the vibrant cultural manifestations at the market level and the declining presence of local inhabitants in the area, posing a challenge to the longevity of the local culture. The younger generation prioritizes financial gain over cultural identity, creating a barrier to the conservation of cultural traditions. This study emphasizes the need for interdisciplinary approaches that draw on anthropology, ecology, and economics to gain a holistic understanding of the complex interactions between humans, culture, and ecology in the context of MI.
Production or Transmission Investments? A Comparative Analysis
Authors: de Paz Mario Blázquez 
Published: December 2023

Abstract
The European electricity market is moving towards an integration process, and to facilitate that integration and the ow of electricity in that market, the European Transmission System Operator proposes di erent investments in transmission and production capacities. I develop a model of imperfect competition to study those investments, and I identify the economic forces that determine the equilibrium price and the ow of electricity: The size and the competitive e ects. I prove formally when those forces operate simultaneously or independently, and how they determine consumers’ surplus and suppliers’ pro ts. I prove that an investment in transmission capacity outperforms an investment in production capacity by maximizing consumers’ welfare, but the performance in terms of suppliers’ pro ts is ambiguous.
Exploring the Thermodynamic Characteristics of Isoelectronic Diatomic Interstellar Molecular Species: Oxygen- and Sulphur-containing Species
Authors: Oladimeji Enock Oluwole , Etim Emmanuel Edet , Umeh Emmanuel Chukwuebuka , Shinggu John Paul , Oluwadare Oluwatimilehin Joshua , Odeyemi Oluwakemi Mary 
Published: December 2023

Abstract
We studied the thermodynamic properties of 18 isoelectric diatomic interstellar molecular species (known and potential) containing oxygen and the corresponding isoelectronic atom; Sulphur, by providing a comprehensive data set for these molecules of astrophysical importance. We began this by computing its partition function q with the GAUSSIAN 09 suite of programs, the thermodynamics properties such as the entropy S, internal energy U, free energy F, heat capacity H etc. were derived. We showed the isoelectronic effect of these Sulphur and Oxygen containing molecular species on several interstellar molecules at temperatures ranging from 0K to 2×106 K (i.e., from the coldest place in the universe to the mean temperature of the interstellar medium).