bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valproate discontinuation in girls and women of childbearing age with epilepsy: An Italian multicenter retrospective study on prescribing patterns and outcomes
Authors: Esposto Roberta , Falcicchio Giovanni , Zambrelli Elena , Cerulli Irelli Emanuele , Monti Giulia , Ranzato Federica , Giuliano Loretta , La Neve Angela , Galimberti Carlo Adrea , Belotti Laura Maria Beatrice , Turner Katherine , Catania Cecilia , Polo Diana , Todaro Valeria , Bisulli Francesca , Mostacci Barbara ,   Appendix A: Epilepsy and Gender Commission of the LICE (Italian chapter of the ILAE)
Published: January 2025

AbstractObjectiveThis study aimed to identify prescribing behaviors in women of childbearing potential (WOCP) with epilepsy already taking valproate (VPA), and to investigate the relationship between VPA maintenance, substitution, reduction, or withdrawal as part of polytherapy, and seizure worsening or relapse.MethodsWe retrospectively reviewed the prescription behaviors and seizure outcomes in WOCP (16–50 years of age) with epilepsy, referred to eight Italian epilepsy centers, who were taking VPA for at least 1 year between 2014 and 2019.ResultsAmong 750 women (~12% of all WOCP), 528 (70.4%) maintained VPA unchanged throughout the observation period, 103 (13.7%) replaced VPA with another antiseizure medication (ASM), 90 (12%) reduced VPA, and 29 (3.9%) discontinued VPA in polytherapy. Focal epilepsy was most strongly associated with VPA withdrawal (odds ratio [OR] 2.96, 95% confidence interval [CI] 1.38–6.38), whereas generalized epilepsy was most associated with its non‐withdrawal (reduction/switch/maintenance) (OR .31, 95% CI .14–.68). Intellectual disability, higher seizure frequency, and higher VPA doses were linked to VPA continuation. VPA withdrawal from polytherapy was associated with a higher risk of tonic–clonic seizure worsening (OR 2.91, 95% CI 1.09–7.77) compared to non‐withdrawal.SignificanceVPA was rarely withdrawn or substituted in WOCP with epilepsy, in secondary and tertiary care settings following European regulatory restrictions. This likely reflects a population with severe epilepsies where VPA is difficult to replace; whereas women with milder epilepsies likely discontinued VPA earlier, as evidenced by its low overall prescription frequency. Withdrawal of VPA from a polytherapy regimen was associated with a threefold increased risk of seizure exacerbation.
Mindfulness protects relationship quality from stress: Roles of trait mindfulness and relationship mindfulness
Authors: Zheng Yunzhi , Marroquin Crystal G. , Kimmes Jonathan G. 
Published: January 2025

AbstractObjectiveThis study aimed to empirically test how trait mindfulness (i.e., one's general tendency to be mindful) and relationship mindfulness (i.e., being mindful in relationships) protect couple relationships from stress and the potential extra buffer perceived partner relationship mindfulness provides.BackgroundStress has harmful effects on couple relationships, but mindfulness may mitigate such effects. Yet, no study has empirically tested the distinct but complementary roles various forms of mindfulness play in this process.MethodA sample of 249 individuals in romantic relationships completed a cross‐sectional survey that included measures of mindfulness, perceived stress, and relationship quality.Results(a) Trait mindfulness was associated with better relationship quality through reduced perceived stress. (b) Relationship mindfulness moderated the link between perceived stress and negative relationship quality and was a moderated mediator in the model. (c) Perceived partner relationship mindfulness served as an extra buffer on the link between perceived stress and negative relationship quality.ConclusionThe results extended the theoretical model of mindfulness and romantic relationships by empirically demonstrating the various roles of mindfulness in protecting relationships from stress.ImplicationsPractitioners should consider targeting both trait mindfulness and relationship mindfulness, as well as promoting perceived partner relationship mindfulness and joint participation in mindfulness‐based couple interventions.
Fully guided system for position‐predictable autotransplantation of teeth: A randomized clinical trial
Authors: Li Yongqi , Lin Zhiyan , Liu Yudong , Chen Guangwei , Li Chengwei , Wu Huilin , Wang Xuelian , Liu Ye , Kuang Minyi , Zhou Libin 
Published: January 2025

AbstractAimAutotransplantation of teeth (ATT) is a viable biological method for addressing dental defects. The objective was to achieve occlusal reconstruction‐orientated ATT to enhance functionality and obtain optimal location and adjacency. This study proposes a new concept of a guide (a fully guided system) to achieve position‐predictable ATT.MethodologyThis study included 30 transplants in 29 patients who were randomly divided into two groups during the initial examination using a single‐blind method. The experimental group comprised 15 transplants in 14 patients who underwent surgery using a fully guided system. Fifteen transplants were performed on 15 patients in the control group using only a replica.ResultsThe mean number of repeated teeth autotransplantation attempts and mean preparation time exhibited no significant differences. The mean follow‐up period was 1 year. Twenty‐six transplants were followed up clinically, while four were only followed up by phone calls. The experimental group demonstrated a 100% success rate, whereas the control group exhibited a 70% success rate, with an overall 100% survival rate. 3D analysis: Deviation of both angle and distance was calculated for evaluation of accuracy. The mean centre deviation of teeth in experiment group was 0.79 mm (95% confidence interval [CI], 0.51–1.08) compared to 1.79 mm (95% CI, 1.10–2.47) in control group (p < .05). The mean of average index points distance deviation showed a significant difference. The mean angle deviation of long axis in experiment group was 3.87° (95% CI, 2.25–5.49) compared to 12.98° (95% CI, 8.64–17.31) in control group (p < .05). The angle deviation of long axis in mesio‐distal direction, buccal‐lingual direction and rotation showed a significant difference also.ConclusionsThe results of the analysis indicated that the fully guided system increased the predictability of achieving an ideal transplant position with intuitive data, establishing a solid foundation for optimal dental functional recovery and restoration. However, this study had limitations regarding the generalisability of the design of the optimal location for transplantation and the equipment requirements for clinical procedures. Therefore, further research on the screening of indications for guided systems and location planning is necessary.Clinical Trial RegistrationThis study was registered on the Chinese Clinical Trial Registry (Registration Number: ChiCTR 2300074646).
Understanding the CMAS corrosion behavior of high‐entropy (La0.2Sm0.2Er0.2Y0.2Yb0.2)2Ce2O7
Authors: Xu Liang , Gao Hongfei , He Xin , Niu Min , Dai Zhiwei , Ni Haotian , Su Lei , Wang Hongjie 
Published: January 2025

AbstractCeramic thermal barrier coating (TBC) materials are used to protect the superalloys from the damage of harmful high‐temperature airflow and improve the efficiency of jet and gas turbine engines. However, the long‐term application of TBC materials and the robustness of these materials can be destroyed by aggressive calcium‐magnesium‐alumina‐silicate (CMAS) melt during high‐temperature service. Increasing the configuration entropy of material by doping multiple principal components has become a research hotspot in the design of corrosion‐resistant thermal barrier coating material and has opened an infinite space of chemical composition, structure, and material properties. In this study, high‐entropy (La0.2Sm0.2Er0.2Y0.2Yb0.2)2Ce2O7 was synthesized and its CMAS corrosion behavior was investigated by experimental investigation and first‐principles calculation. The effects of the increase of configurational entropy and the subsequent potential effects on the CMAS corrosion behavior of Ce‐based fluorite oxides have been sufficiently investigated. By compared with control samples, the high‐entropy (La0.2Sm0.2Er0.2Y0.2Yb0.2)2Ce2O7 possesses the minimum infiltration depth of CMAS melts and the denser corrosion reaction layer, indicating the best corrosion resistance. The corrosion resistance mechanism of high‐entropy (La0.2Sm0.2Er0.2Y0.2Yb0.2)2Ce2O7 was studied by first‐principles calculation. The greater stability and resistance to segregation of CMAS melt in the CMAS/(La0.2Sm0.2Er0.2Y0.2Yb0.2)2Ce2O7 system, the poor adsorption capacity for CMAS melt which leads to a weak infiltration ability of CMAS melt; the weakest interfacial chemical reaction at the interface indicated by the smallest value of Griffith rupture work and the least species migration of high‐entropy fluorite oxide can be responsible to the enhanced corrosion resistance. Our work reveals that increasing the configuration entropy can be an effective strategy for TBC material to enhance corrosion resistance.
Predictors of Arrhythmia Recurrence After Cryoballoon Ablation for Persistent Atrial Fibrillation: A Sub‐Analysis of the Cryo Global Registry
Authors: Chun K. R. Julian , Stellbrink Christoph , Murakami Masato , Drephal Christian , Oh Il‐Young , van Bragt Kelly A. , Becker Daniel , Anselme Sylvain , Todd Derick , Kaczmarek Krzysztof , Nitta Junichi 
Published: January 2025

ABSTRACTIntroductionFreedom from recurrences of atrial tachyarrhythmia (ATA) is suboptimal after pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (PsAF). This sub‐analysis from the Cryo Global Registry sought to investigate predictors of ablation success after PVI using cryoballoon ablation (CBA) for PsAF.Methods and ResultsATA recurrence was defined as ≥ 30 s recurrence of atrial fibrillation, atrial flutter or atrial tachycardia after a 90‐day blanking period and through 12‐months. Univariate and multivariable Cox regression analysis (with ATA recurrence as an endpoint) was performed to identify CBA responders. PsAF patients (N = 882) were on average 63.9 ± 11.3 years old (69.2% male), and freedom from ATA recurrence was 79.7% (76.8%–82.2%). Longer elapsed time from PsAF diagnosis to ablation (hazard ratio [HR] 1.07 (95% confidence interval [CI]: 1.03–1.11); p = 0.002) and a larger number of previously failed antiarrhythmic drugs (HR 1.39 (95% CI: 1.13–1.70); p < 0.002) were shown to be independent predictors of ATA recurrence in a multivariate model which included 703 evaluated patients.ConclusionThese real‐world results provide important insights to guide referral of PsAF patients, including the benefits of earlier treatment via CBA.
Ethics Committees' Practices in Healthcare, Banking and Research: Key Requirements for Their Functionality
Authors: Arık Tuğba , Michl Susanne 
Published: January 2025

ABSTRACTRationaleTo meet concerns about ethical and unethical behavior in their work environments and workplaces, organizations began establishing ethics programs that contain ethics committees (ECs). There is now a tradition and diverse use of ECs for ethical decision‐making in many different organizational settings. In addition, ECs have been subject to many publications in books and articles in the scientific literature. Yet, until now no comparative analysis has been published that brings together ECs' practices in different sectors.Aims and ObjectivesThis article aims to bridge this knowledge gap and illustrate which main requirements for ECs' practices need to be addressed to help ECs meet their anticipated functions.MethodTo do so, this paper lays out a study based on an exploratory, qualitative design using focus groups and individual expert interviews that compare ECs' practices in the healthcare, banking, and scientific research sectors (as far as dual use of research is concerned).ResultsBased on the results of this study we were able to make a distinction between two main categories: moral authority and trustworthiness. We were also able to identify three sub‐categories: legitimation, mode, and outreach.ConclusionBased on the exploratory analysis in this study, we conclude that there are the following three distinct main requirements for the functionality of ECs: (1) a dialog between EC members and other stakeholders, (2) an approach that considers various possible modes (reactive, screening, moderating, and preventive) to enhance the quality of ECs’ decision‐making processes and (3) an outreach to all relevant EC stakeholders for the further validation of the main requirements found for ECs functionality.
The challenge of managing and retaining risks: How a paradox perspective reduces harm, realizes opportunities and enriches performance
Authors: Soane Emma 
Published: January 2025

AbstractManagers in many kinds of organizations encounter risks in their daily work. A key challenge involves finding ways to manage risks and prevent harm to individuals or organizations, while retaining risks to realize opportunities. These pressures create a tension between risk management and risk retention that prevails in many sectors and is especially consequential in organizations where failures to address it may be fatal. I use inductive analysis to explore qualitative data from 72 television production company managers whose work has potential for trauma, injury and death as well as success. I find the tension between risk management and risk retention can be understood in relation to perceptions and goals. I contribute to theorizing about organizational paradox by showing how perceptions of the tension differ at the individual level. Some managers perceive the tension as a trade‐off, focus on risk management and emphasize safety goals. Other managers perceive the tension as a paradox and emphasize wider performance goals that encompass safety and risk. These managers use their agency to foster empowerment and creativity. Doing so enhances to both risk management and risk retention, creating a dynamic equilibrium that reduces harm, realizes opportunities and enriches performance.
Ecology and Phylogenetic Position of the Spoon Worm, Ikeda pirotansis (Menon and DattaGupta, 1962), (Annelida: Echiura) in Kuwait, Northwestern Arabian Gulf
Authors: Nithyanandan Manickam , Tanaka Masaatsu , Al‐Yamani Faiza , Al‐Kandari Manal , Sanjeevi Prakash , Rethinaraj Chandran , Kumar Raja Dinesh , Kesavan Ratheesh 
Published: January 2025

ABSTRACTIkeda pirotansis (Menon and DattaGupta 1962), previously known only from intertidal habitats, is now reported for the first time from subtidal habitats in Kuwait, northwestern Arabian Gulf. This finding eliminates its ecological separation from its congener Ikeda taenioides, which is endemic to Japan. The comparison of proboscis morphology (shape, length and colour pattern) between intertidal and subtidal I. pirotansis shows no significant differences. Furthermore, mtDNA extracted from proboscis samples and analysed for the COX1 gene revealed no genetic distance between intertidal and subtidal samples, confirming that I. pirotansis also colonises subtidal habitats. Phylogenetic analysis indicated that the I. pirotansis from Kuwait and India clustered together, forming a monophyletic clade, and warrants more extensive regional sampling to study the detailed taxonomic and evolutionary history of the order Echiuroidea.
Modeling the collective behavior of pedestrians with the spontaneous loose leader–follower structure in public spaces
Authors: Xu Jie , Xu Dengyu , Wu Jing , Shi Xiaowei 
Published: January 2025

AbstractGaining insights into pedestrian flow patterns in public spaces can greatly benefit decision‐making processes related to infrastructure planning. Interestingly, even pedestrians are unfamiliar with one another, they often follow others, drawing on positive information and engaging in a spontaneous collective behavior of pedestrians. To model this collective behavior, this paper proposed a social force‐based technique characterized by a loosely defined leader–follower structure. First, a complex field‐based phase transfer entropy (PTE) method was applied to measure the difference in information flow between pedestrians. Setting the detecting threshold with the 3 sigma principle, the radial basis function (RBF) was utilized to identify the leader in the collective. Integrating the PTE, RBF, and social force model (SFM), a comprehensive model (PTE‐RBF‐SFM) was developed to simulate collective behavior. Some bidirectional pedestrian flow data, collected from Fairground Düsseldorf, were used to validate the model in a real‐world setting. The results showed that the proposed model provided more realistic trajectories than benchmark models, and the spontaneous leader–follower structure was found to change over time and stable with time interval prolonging.
From Teeth to Body: The Complex Role of Streptococcus mutans in Systemic Diseases
Authors: Xiao Haowen , Li Yuqing 
Published: January 2025

ABSTRACTStreptococcus mutans, the principal pathogen associated with dental caries, impacts individuals across all age groups and geographic regions. Beyond its role in compromising oral health, a growing body of research has established a link between S. mutans and various systemic diseases, including immunoglobulin A nephropathy (IgAN), nonalcoholic steatohepatitis (NASH), infective endocarditis (IE), ulcerative colitis (UC), cerebral hemorrhage, and tumors. The pathogenic mechanisms associated with S. mutans frequently involve collagen‐binding proteins (CBPs) and protein antigens (PA) present on the bacterial surface. These components facilitate intricate interactions with the host immune system, thereby potentially contributing to various pathological processes. Specifically, CBP is implicated in the deposition of IgA and complement component C3, which exhibits characteristics reminiscent of IgAN‐like lesions through animal models, recent clinical studies suggest a potential involvement of S. mutans in IgAN. In addition, CBP binds to complement component C1q, effectively inhibiting the classical activation pathway of the complement system. In addition, CBP promotes the induction of host cells to produce interferon‐gamma (IFN‐γ). Furthermore, CBP leads to direct inhibitory effects on platelets and the activation of matrix metalloproteinase‐9 (MMP‐9) at sites of vascular injury. Moreover, PA enhances the ability of S. mutans to invade hepatic tissue. Through utilization of its PAc, S. mutans excessively produces kynurenine (KYNA), which promotes the development and progression of oral squamous cell carcinoma (OSCC). This article synthesizes the latest advancements in understanding the mechanisms of intricate interactions between S. mutans and various systemic conditions in humans, expanding our perspective beyond the traditional focus on dental caries.
Concurrent Micra Leadless Pacemaker Implantation and AVN Ablation: Computer Modeling of Novel Risk Mitigation Strategy
Authors: Nelson Daniel Wetherbee , Erickson Lynn , Zilinski Jodi L. , Zhao Yanzhu , Karos Anna , Whitman Teresa , Niazi Imran K. 
Published: January 2025

ABSTRACTBackgroundConcurrent Micra leadless pacemaker (Medtronic, Minneapolis, Minnesota) implantation and atrioventricular node (AVN) ablation has been shown to be feasible and safe in patients with symptomatic, drug‐refractory atrial fibrillation (AF). However, major complications within the 30 days after concurrent Micra implantation and AVN ablation have been reported. We evaluated the efficacy and safety of the concurrent procedure at our institution.MethodsWe conducted a single‐center, retrospective case series of patients who underwent concurrent Micra implantation and radiofrequency (RF) AVN ablation from January 2019 to May 2023. A simulated computer model was created to characterize the interaction between the dissipated power at the Micra cathodal electrode as a function of the distance between the RF ablation catheter and the location of the return electrode.ResultsFifteen patients were included. Most were elderly, White, female, and had persistent AF. One had transient, acute loss of ventricular capture that resulted in asystole and required emergent pacing from the ablation catheter. A proposed strategy of moving the RF return electrode to a cranial position from a caudal position was shown by computer modeling to direct more RF current away from the Micra and lower the dissipated power at the Micra cathodal electrode.ConclusionConcurrent Micra implantation and AVN ablation is feasible and safe and has high procedural success. An acute rise in pacing threshold can occur from RF energy, resulting in asystole. Computer modeling showed that placing the RF return electrode in the cranial position resulted in lower dissipated power at the Micra cathodal electrode.
OsCYP22 Interacts With OsCSN5 to Affect Rice Root Growth and Auxin Signalling
Authors: Ma Tao , Zhang Xiaofang , Jia Lihuiying , Hua Yunyan , Li Xu , Qiu Shiyou , Chen Yujie , Wang Xiaofei , Zhu Shihua , Mao Chuanzao , Xu Linying , Ding Wona 
Published: January 2025

ABSTRACTBeyond structural support, plant root systems play crucial roles in the absorption of water and nutrients, fertiliser efficiency and crop yield. However, the molecular mechanism regulating root architecture in rice remains largely unknown. In this study, a short‐root rice mutant was identified and named Oscyp22. Oscyp22 showed impairment in the growth of primary, adventitious and lateral roots. Histochemical and fluorescent staining analyses revealed reduced cell elongation and division activity in the root of Oscyp22. Further analysis showed that Oscyp22 displayed an impaired response to auxin treatment, indicating a disruption in the auxin signal transduction. Transcriptome analysis and auxin content measurement suggested that OsCYP22 might be involved in auxin synthesis and transport. Protein assays demonstrated that OsCYP22 could interact with OsCSN5 and induce its rapid degradation. Notably, Oscsn5 mutants also showed short root phenotypes and deficiencies in auxin response. These findings suggest that OsCYP22 plays a role in rice root growth potentially through auxin signalling and OsCSN5 stability.