bluuebunny/crossref_metadata_2025_split huggingface dataset:
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion
Authors: Goldman Andres , Mullokandov Michael , Zaltsman Yehudit , Regev Limor , Levin-Zaidman Smadar , Gross Atan 
Published: December 2023

AbstractFusion of the outer mitochondrial membrane (OMM) is regulated by mitofusin 1 (MFN1) and 2 (MFN2), yet the differential contribution of each of these proteins is less understood. Mitochondrial carrier homolog 2 (MTCH2) also plays a role in mitochondrial fusion, but its exact function remains unresolved. MTCH2 overexpression enforces MFN2-independent mitochondrial fusion, proposedly by modulating the phospholipid lysophosphatidic acid (LPA), which is synthesized by glycerol-phosphate acyl transferases (GPATs) in the endoplasmic reticulum (ER) and the OMM. Here we report that MTCH2 requires MFN1 to enforce mitochondrial fusion and that fragmentation caused by loss of MTCH2 can be specifically counterbalanced by overexpression of MFN2 but not MFN1, partially independent of its GTPase activity and mitochondrial localization. Pharmacological inhibition of GPATs (GPATi) or silencing ER-resident GPATs suppresses MFN2’s ability to compensate for the loss of MTCH2. Loss of either MTCH2, MFN2, or GPATi does not impair stress-induced mitochondrial fusion, whereas the combined loss of MTCH2 and GPATi or the combined loss of MTCH2 and MFN2 does. Taken together, we unmask two cooperative mechanisms that sustain mitochondrial fusion.
NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression
Authors: Xie Shaofang , Yuan Lei , Sui Yue , Feng Shan , Li Hengle , Li Xu 
Published: December 2023

AbstractNonalcoholic fatty liver disease (NAFLD) is mainly characterized by excessive fat accumulation in the liver, and it is associated with liver-related complications and adverse systemic diseases. NAFLD has become the most prevalent liver disease; however, effective therapeutic agents for NAFLD are still lacking. We combined clinical data with proteomics and metabolomics data, and found that the mitochondrial nucleoside diphosphate kinase NME4 plays a central role in mitochondrial lipid metabolism. Nme4 is markedly upregulated in mice fed with high-fat diet, and its expression is positively correlated with the level of steatosis. Hepatic deletion of Nme4 suppresses the progression of hepatic steatosis. Further studies demonstrated that NME4 interacts with several key enzymes in coenzyme A (CoA) metabolism and increases the level of acetyl-CoA and malonyl-CoA, which are the major lipid components of the liver in NAFLD. Increased level of acetyl-CoA and malonyl-CoA lead to increased triglyceride levels and lipid accumulation in the liver. Taken together, these findings reveal that NME4 is a critical regulator of NAFLD progression and a potential therapeutic target for NAFLD.
TMEM25 is a Par3-binding protein that attenuates claudin assembly during tight junction development
Authors: Kamakura Sachiko , Hayase Junya , Kohda Akira , Iwakiri Yuko , Chishiki Kanako , Izaki Tomoko , Sumimoto Hideki 
Published: December 2023

AbstractThe tight junction (TJ) in epithelial cells is formed by integral membrane proteins and cytoplasmic scaffolding proteins. The former contains the claudin family proteins with four transmembrane segments, while the latter includes Par3, a PDZ domain-containing adaptor that organizes TJ formation. Here we show the single membrane-spanning protein TMEM25 localizes to TJs in epithelial cells and binds to Par3 via a PDZ-mediated interaction with its C-terminal cytoplasmic tail. TJ development during epithelial cell polarization is accelerated by depletion of TMEM25, and delayed by overexpression of TMEM25 but not by that of a C-terminally deleted protein, indicating a regulatory role of TMEM25. TMEM25 associates via its N-terminal extracellular domain with claudin-1 and claudin-2 to suppress their cis- and trans-oligomerizations, both of which participate in TJ strand formation. Furthermore, Par3 attenuates TMEM25–claudin association via binding to TMEM25, implying its ability to affect claudin oligomerization. Thus, the TJ protein TMEM25 appears to negatively regulate claudin assembly in TJ formation, which regulation is modulated by its interaction with Par3.
Machine learning assisted adaptive LDPC coded system design and analysis
Authors: Xie Cong , El‐Hajjar Mohammed , Ng Soon Xin 
Published: December 2023

AbstractThis paper proposes a novel machine learning (ML) assisted low‐latency low density parity check (LDPC) coded adaptive modulation (AM) system, where short block‐length LDPC codes are used. Conventional adaptive modulation and coding (AMC) system includes fixed look‐up table method, which is also called inner loop link adaptation (ILLA) and outer loop link adaptation (OLLA). For ILLA, the adaptive capability is achieved by switching the modulation and coding modes based on a look‐up table using signal‐to‐noise ratio (SNR) thresholds at the target bit error rate (BER), while OLLA builds upon the ILLA method by dynamically adjusting the SNR thresholds to further optimize the system performance. Although both improve the system overall throughput by switching between different transmission modes, there is still a gap to optimal performance as the BER is comparatively far away from the target BER. Machine learning (ML) is a promising solution in solving various classification problems. In this work, the supervised learning based k‐nearest neighbours (KNN) algorithm is invoked for choosing the optimum transmission mode based on the training data and the instantaneous SNR. This work focuses on the low‐latency communications scenarios, where short block‐length LDPC codes are utilized. On the other hand, given the short block‐length constraint, we propose to artificially generate the training data to train our ML assisted AMC scheme. The simulation results show that the proposed ML‐LDPC‐AMC scheme can achieve a higher throughput than the ILLA system while maintaining the target BER. Compared with OLLA, the proposed scheme can maintain the target BER while the OLLA fails to maintain the target BER when the block length is short. In addition, when considering the channel estimation errors, the performance of the proposed ML‐LDPC‐AMC maintains the target BER, while the ILLA system's BER performance can be higher than the target BER.
Optimal dispatch of distributed renewable energy and energy storage systems via optimal configuration of mobile edge computing
Authors: Jiang He , Zhao Yan , Zhou Hang 
Published: December 2023

AbstractThe access of distributed units leads to the rapid increase of power network information services, which brings great problems to the centralized dispatch of power system. To improve the efficiency of data processing and the flexibility of each unit dispatching, first, the areas are divided according to the load characteristics. An operating framework of distributed power system is presented based on offload strategy of mobile edge computing (MEC) and optimal allocation of computational quantity. Second, a novel hierarchical dispatching model is established based on the optimal configuration of MEC. In each area, the upper model takes the total energy consumption of the MEC server and the operating cost of the power system as the objective to calculate the output of each distributed unit and the computational quantity under the optimal offload strategy. The lower model ensures the complete accommodation of renewable energy and the optimal economic operation of the whole area through the introduction of electric vehicles (EVs) and secondary operation of energy storage systems under the constraint of MEC server computing delay. Third, the screening rules of the MEC system computing mode and the simulation strategies of EVs in different areas are proposed. Finally, the effectiveness and superiority of the model are verified by simulation experiments.
Investigation of the Effects of Mat Pilates and Apparatus Pilates on
some Physical Fitness Parameters, Posture, Joint Mobility and Functional
Movement Analysis in Women
Authors: Ünver Gülşah , Aras Dicle 
Published: December 2023

Abstract
Objectives The present study was conducted to investigate the effects of
mat Pilates and apparatus Pilates on some physical fitness parameters, posture,
joint mobility, and functional movement level in adult women.
Materials and Methods A total of 45 female participants were included in
the study, and they were divided into 3 groups of 15 people in each group. The
groups were determined as mat Pilates, apparatus Pilates, and control groups.
While the participants in the mat and the apparatus Pilates groups performed the
exercise program for 12 weeks, the participants in the control group did not
participate in any regular physical activity program. The physical fitness
parameters, posture, joint mobility, and functional movement level of the
participants were evaluated before and after the exercise program.
Results At the end of the exercise program, muscle strength, muscular
endurance, balance, posture score, joint mobility, and functional movement level
increased significantly in both the mat and the apparatus Pilates groups
(p<0.05). For the post-test values of the parameters evaluated within
the scope of the study, a significant difference was found between the mat and
the apparatus Pilates groups in favor of the apparatus Pilates group in terms of
back strength, leg strength, and balance (p<0.05).
Conclusion Both mat and apparatus Pilates exercise programs provided an
increase in muscle strength, muscular endurance, joint mobility, functional
movement level, and positive effects on balance and posture in adult women.
Quality Indicators for Rehabilitation Care Among Patients with
Rheumatic and Musculoskeletal Diseases: A Multicenter Study, Cross sectional
study.
Authors: Makarm Wafaa K , Abu-Zaid Mohammad Hassan , Alramadhani Ibrahim A. , Elsheikh Ahmed M. , Zaghlol Rabab S. 
Published: December 2023

Abstract
Objective Rheumatic and musculoskeletal diseases (RMDs) are among the most
common disorders in the general population. Rehabilitation quality indicators
(QIs) are one tool for assessing the quality and efficiency of healthcare
resources. The aim of this study was to utilize one of the validated QIs to
assess the current quality of rehabilitation services for RMDs in Egypt and
Saudia Arabia.
Materials and Methods A cross-sectional survey study, in which
rehabilitation unit managers answered 19 structure questions at the start of the
test period using a web-based, structured questionnaire. While one to two months
after completing a rehabilitation program, the patient answered 14 written
questions based on 11 process and 3 outcome quality indicators.
Results 36 Egyptian and 43 Saudi healthcare workers, as well as 350
Egyptian and 331 Saudi patients, completed the questionnaires. In Egypt and
Saudi Arabia, more than 60% of rehabilitation units and service users
agreed on the majority of quality indicator domains, including patient
assessment and rehabilitation outcomes. The lowest pass rates for a
rehabilitation unit structure QIs were the planning of two meetings between the
patient and the team, meeting with next of kin, and access to meetings with some
professionals, which also reflected the lowest quality domains observed by the
service user in the process as regards patient participation in the
rehabilitation process and planning of the period after rehabilitation.
Conclusion The quality of RMDs rehabilitation programs varies widely, both
nationally and across countries. Quality improvement in specific aspects of RMD
rehabilitation care is required.
The 6-minute Run Test: Validation and Reference Equations for
Adults
Authors: Leuschner Malte , Grauduszus Martin , Friesen David , Ferrari Nina , Klaudius Marlen , Joisten Christine 
Published: December 2023

AbstractEndurance performance tests directly measuring cardiorespiratory fitness are
complex, but field tests indirectly assessing maximum oxygen uptake
(VO2max) are an alternative. This study aimed to validate the
6-minute run test in adults, comparing it to the established shuttle run test,
and to create reference equations. The cross-over design involved healthy adults
aged 18–65 undertaking both tests, separated by a two-hour interval. The
6-minute run test required participants to run around a volleyball court for six
minutes, aiming to maximize distance covered. The shuttle run involved
participants covering 20 meters in defined time intervals at increasing speeds.
Parameters measured included 6-minute run test distance, heart rates, calculated
maximum oxygen uptake during the shuttle run, and total shuttle count. The study
enrolled 250 participants (134 men and 116 women). Men averaged 1195.7 m
(SD=161.4), while women averaged 1051.2 m (SD=148.0) in
six minutes. The strongest correlation was found between the distance covered in
the 6-minute run test and the total shuttle count (r=0.91,
p<0.001). Two predictive models for 6-minute run test distance were
developed and normative values for different sex-specific age clusters were
established. The study showed that the 6-minute run test is valid as a practical
endurance test for adults aged 18–65.
Synthesis of Anti-oxidant Steroids by Hybridisation with Nitroxides
Authors: Bottle Steven E. , Soltau Carl P. , Weir Naomi E. , Martyn Alexander P. 
Published: December 2023

AbstractSteroidal–nitroxide hybrid molecules and non-radical controls were synthesised in good yields using simple carbodiimide coupling. An unexpected product arose from reactions between the nitroxide moiety and the solvent THF. Methoxyamine derivatives of the nitroxide drug hybrids were produced using Fenton chemistry without side reactions occurring on the steroid. The hybrid compounds bind to the glucocorticoid receptor and are relevant for the study of radical biological chemistry and redox-related disease processes.
DBU-Mediated Oxidation of β-Dicarbonyls: Formation of Hydroxylated and Rearranged Products under Air Atmosphere
Authors: Tian Hongyu , Liang Sen , Peng Shuai , Wang Tianqi , Zhao Xixuan , Yao Boan , Zhao Kaishuo , Liu Yongguo , Sun Baoguo 
Published: December 2023

AbstractThe oxidation of different β-dicarbonyls in acetonitrile has been explored under an air atmosphere in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The presence of DBU resulted in the formation of hydroxylated products or rearrangement products derived from hydroxylated products. Specifically, the transformation of 2-oxocyclopentanecarboxylates to 2-hydroxyhexanedioates was achieved with good yields when additional 1,2-bis(diphenylphosphino)ethane and ROH were present. DBU proved to be indispensable for this transformation and showed specificity beyond its usual role as a base.
Recent Developments on the Earth-Abundant-Metal-Catalyzed α,β-Dehydrogenation of Carbonyl Compounds
Authors: Dai Peng-Fei , Kang Yan-Biao , Li Qiang-Qiang , Qu Jian-Ping 
Published: December 2023

Abstractα,β-Unsaturated carbonyl compounds are versatile building blocks in modern organic synthetic chemistry. In recent decades, various approaches have been established to access to these products, such as halogenation–dehydrohalogenation methods, organosulfur methods, organoselenium methods, earth-abundant-metal-catalyzed methods, precious-metal-catalyzed methods, and metal-free methods, etc. Among these, earth-abundant-metal-catalyzed methods (i.e., iron, cobalt, nickel, copper) continue to attract the attention of chemists because they are readily available, inexpensive, and environmentally friendly. Presently, there are only a few reviews covering earth-abundant-metal-catalyzed α,β-dehydrogenations. Hence, the aim of this short review is to provide a detailed update on the recent developments on earth-abundant-metal-catalyzed α,β-dehydrogenations of carbonyl compounds. 1	Introduction2	Iron-Catalyzed Dehydrogenation3	Cobalt-Catalyzed Dehydrogenation4	Nickel-Catalyzed Dehydrogenation5	Copper-Catalyzed Dehydrogenation6	Conclusion
Time-course Changes of Field- and Laboratory-based Performance
Indicators in Junior Cyclists Through a Season
Authors: Revuelta Carlos , Alejo Lidia B. , Valenzuela Pedro L. , Montalvo-Perez Almudena , de la Calle Víctor , Agundez Alberto , Lucia Alejandro , Barranco-Gil David 
Published: December 2023

AbstractThis study aimed to assess the seasonal evolution of field-based and
laboratory-based performance indicators in cyclists. Thirteen Junior male road
cyclists (age 17.4±0.5 years) were followed up during a season, which
was divided in three phases: early season (involving mainly training sessions),
mid-season (including the first competitions), and late season (including the
major competitions of the season). During each phase, field-based power output
data were registered for the assessment of maximum mean power values, and
laboratory-based endurance (ramp test and simulated 8-minute time trial), muscle
strength/power (squat, lunge, hip thrust) and body composition
indicators (dual-energy X-ray absorptiometry) were also assessed. A progressive
(p<0.01) increase in maximum mean power values (e.g., 3.8±0.3
and 4.5±0.4 watts/kg in early and late season, respectively, for
60-minute efforts) and on 8-minute time trial performance (i.e., 5.3±0.3
and 5.6±0.4 watts/kg, respectively) was observed through the
season. Yet, more “traditional” endurance indicators (i.e.,
ventilatory threshold, respiratory compensation point, or maximum oxygen uptake)
seemed to show a ceiling effect beyond the mid-season. In addition, neither peak
power output, body composition, nor muscle strength indicators followed a
similar pattern to the aforementioned field-based indicators. In summary, in
Junior cyclists field-based indicators seem more sensitive to monitor endurance
cyclists’ changes in actual fitness and performance capacity than more
“traditional” laboratory-based markers in Junior cyclists.
Self-Reported Perceptions of Preparedness among Incoming Ophthalmology Residents
Authors: Lin Benjamin R. , Nguyen Geoffrey , Sridhar Jayanth , Cavuoto Kara 
Published: December 2023

Abstract
Purpose The purpose of this study was to assess the self-perceived preparedness of incoming postgraduate year 1 (PGY1) and postgraduate year 2 (PGY2) ophthalmology interns/residents to carry out core competencies in ophthalmology.
Methods An online survey was created using the Survey Monkey survey platform and distributed to all ophthalmology resident applicants to the Bascom Palmer Eye Institute from the 2021 to 2022 and 2022 to 2023 application cycles. The survey contained questions pertaining to demographics, prior ophthalmic experience, online resources that were used to prepare for ophthalmology, and self-perceived preparedness to carry out key clinical skills in ophthalmology.
Results A total of 170 responses were obtained (16.1% response rate). Of those, 119 (70%) were incoming PGY1 interns and 51 (30%) were incoming PGY2 residents for the 2022 to 2023 academic year. Most respondents (90.6%, n = 154) reported that their ophthalmology residency was affiliated with an integrated ophthalmology intern year. Incoming PGY2s moderately agreed with the statement that they felt as prepared to see patients in ophthalmology as they do in other surgical subspecialties, whereas incoming PGY1s only mildly agreed with that statement (p = 0.003). Both incoming PGY1s and PGY2s felt most prepared to obtain histories relating to basic ophthalmic complaints and felt least prepared to read and interpret ophthalmic imaging studies. The most popular online resources used by respondents in order of popularity were EyeGuru (35.2%, n = 60), EyeWiki (32.9%, n = 56), Tim Root/OphthoBook (26.5%, n = 45), American Academy of Ophthalmology (13.5%, n = 23), and EyeRounds/University of Iowa (13.5%, n = 23).
Conclusion A major challenge in integrating ophthalmic education into the medical school curricula is the gradual shift toward shorter preclinical curricula. However, having a core foundation of ophthalmic knowledge is critical for incoming ophthalmology residents to be able to maximize their specialty-specific training. Integrated ophthalmology intern years likely play a significant role in the increased self-efficacy of incoming PGY2s compared with incoming PGY1s. Adopting nontraditional teaching methods like flipped classroom learning, utilizing online medical education resources, and continuing to increase ophthalmology exposure during PGY1 year may better prepare incoming PGY2s to operate independently in ophthalmology settings.
Stand-Alone Percutaneous Pedicle Screw Lumbar Fixation to Indirectly Decompress the Neural Elements in Spinal Stenosis: A Radiographic Assessment Case Series
Authors: Gazzeri Roberto , Panagiotopoulos Konstantinos , Galarza Marcelo , Leoni Matteo Luigi Giuseppe , Agrillo Umberto 
Published: December 2023

Abstract
Background The ideal surgical treatment of lumbar canal stenosis remains controversial. Although decompressive open surgery has been widely used with good clinical outcome, minimally invasive indirect decompression techniques have been developed to avoid the complications associated with open approaches. The purpose of this study was to evaluate the radiologic outcome and safety of the indirect decompression achieved with stand-alone percutaneous pedicle screw fixation in the surgical treatment of lumbar degenerative pathologies.
Methods Twenty-eight patients presenting with spinal degenerative diseases including concomitant central and/or lateral stenosis were treated with stand-alone percutaneous pedicle screw fixation. Radiographic measurements were made on axial and sagittal magnetic resonance (MR) images, performed before surgery and after a mean follow-up period of 25.2 months. Measurements included spinal canal and foraminal areas, and anteroposterior canal diameter.
Results Percutaneous screw fixation was performed in 35 spinal levels. Measurements on the follow-up MR images showed statistically significant increase in the cross-sectional area of the spinal canal and the neural foramen, from a mean of 88.22 and 61.05 mm2 preoperatively to 141.52 and 92.18 mm2 at final follow-up, respectively. The sagittal central canal diameter increased from a mean of 4.9 to 9.1 mm at final follow-up. Visual analog scale (VAS) pain score and Oswestry Disability Index (ODI) both improved significantly after surgery (p < 0.0001).
Conclusion Stand-alone percutaneous pedicle screw fixation is a safe and effective technique for indirect decompression of the spinal canal and neural foramina in lumbar degenerative diseases. This minimally invasive technique may provide the necessary decompression in cases of common degenerative lumbar disorders with ligamentous stenosis.
A longitudinal study on content learning of EMI students in Vietnam from Bourdieusian perspectives
Authors: Nguyen An 
Published: December 2023

Abstract
English as a medium of instruction (EMI) has increased rapidly. This study adopts a Bourdieusian framework to investigate
two research questions. First, it examines whether there is a change in the content learning of EMI business students over time. Second, it
explores the connection between students’ social milieus and their academic performance in an EMI tertiary context. The study collects GPA
scores and background survey data from EMI and Vietnamese-medium instruction (VMI) students over a two-year period. The findings reveal that
EMI students experience a greater decline in learning when transitioning from year 3 to year 4, compared to VMI students.
Additionally, students with higher levels of cultural capital, as measured by English entry grades and English private tuition time,
experience a drop in their academic performance. From a Bourdieusian perspective, the EMI group lacks the necessary form of capital to
reproduce their class privilege in relation to the VMI cohort over time. Theoretically, the study reinforces the notion that EMI serves as a
mechanism of cultural reproduction that aligns with the unequal distribution of resources. Empirically, it contributes to the understanding
of EMI’s impacts, and its implications for policy implementation in Vietnam and similar contexts.