bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases
Authors: Carlos de Vicente Juan , Junquera Gutiérrez Luis Manuel , Zapatero Agustín Herrero , Fresno Forcelledo Manuel Florentino , Hernández‐Vallejo Gonzalo , López Arranz Juan Sebastián 
Published: January 2004

AbstractBackground. Aberrations of the p53 gene and overexpression of its protein are widely recognized markers of malignancy including oral squamous cell carcinomas. This study was performed to evaluate the relationship of immunoexpression of p53 protein in series of 91 squamous cell carcinomas of the oral cavity with clinicopathologic parameters and to investigate whether p53 immunoexpression might influence the clinical outcome of the disease.Methods. From a group of 287 consecutive patients, 91 surgically treated ones were randomly selected. P53 protein expression was investigated by means of immunohistochemistry. Clinical and histopathologic data were gathered, and the patient survival was analyzed.Results. Of the oral carcinomas, 52.7% (n = 48) overexpressed p53, using a threshold of 10% stained cell nuclei. There was a negative correlation of p53 immunoexpression with a histologic grade of differentiation (r = −0.236, p = .06) but not with clinical variables. Overall survival rate was 59% at 5 years. In univariate analysis, tumor size, node status, and advanced clinical stage were significantly associated with shortened overall survival. In patients without neck node metastases, p53 showed a strong correlation with survival (p = .01). In multivariate analysis performed only on N0 patients, tumor extension and p53 immunoexpression were found to be the only independent prognostic parameters with relative risks of 1.9 and 4.3, respectively.Conclusions. A strong relationship was observed between p53 immunoexpression and poor prognosis in patients with oral squamous cell carcinomas without neck node metastases. © 2004 Wiley Periodicals, Inc. Head Neck 26: 22–30, 2004
Botulinum toxin type A for the treatment of chronic neck pain after neck dissection
Authors: Vasan Claus Wittekindt , Liu Wei‐Chi , Klussmann Jens‐Peter , Guntinas‐Lichius Orlando 
Published: January 2004

AbstractBackground.Neck dissection surgery is often followed by chronic head and neck pain. To date optimal treatment of this type of pain is lacking. Botulinum toxin type A (BTX‐A) has been shown to be effective in the treatment of myofascial pain syndrome and headache. In a pilot study, we wanted to test the effectiveness of BTX‐A for the treatment of chronic neck pain after neck dissection.Methods.Sixteen patients with chronic neck pain after neck dissection were included in this prospective, open study. Eighty to 320 units of BTX‐A (Dysport) were injected into muscular trigger points. Outcome measures included chronic pain and shooting pain on the basis of visual analog scales and quality of life improvement (EORTC QLQ‐C‐30; EORTC QLQ‐H&N35) before and 4 weeks after treatment.Results.Patients showed a significant reduction in chronic pain (4.5 before to 3.3 after treatment, p = ,005) and in shooting pain (6.1 before to 4.7 after treatment, p = .005). There was a trend toward improvement in global quality of life (QLQ‐C30, p = .097) and an increase on the functional scale “pain” (QLQ‐H&N35, p = .071).Conclusions.BTX‐A treatment of subjects with chronic neck pain after neck dissection resulted in a fast and significant reduction of pain. A significant improvement in quality of life may be expected in a longer time course after treatment. © 2004 Wiley Periodicals, Inc. Head Neck 26: 39–45, 2004
Polymorphisms of GSTT1 and related genes in head and neck cancer risk
Authors: Evans Adam J. , Henner William David , Eilers Kristi M. , Montalto Michelle A. , Wersinger Emily M. , Andersen Peter E. , Cohen James I. , Everts Edwin C. , McWilliams Jeffrey E. , Beer Tomasz M. 
Published: January 2004

AbstractBackground. Glutathione S‐transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC).Method. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population‐based controls.Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1–2.5, p = 0.03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5–6.3) and men (OR, 1.2; CI, 0.7–2.1) for the presence of GSTT1.Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women. © 2004 Wiley Periodicals, Inc. Head Neck 26:63–70, 2004
Genetic abnormalities associated with nodal metastasis in head and neck cancer
Authors: Wreesmann Volkert B. , Wang Dorothy , Goberdhan Andy , Prasad Mukesh , Ngai Ivan , Schnaser Erik A. , Sacks Peter G. , Singh Bhuvanesh 
Published: January 2004

AbstractBackground.Lymphatic metastasis represents the single most important clinical prognostic factor in head and neck squamous cell carcinoma (HNSCC), but underlying genetic mechanisms remain ill defined. Genetic differences between primary carcinomas and their corresponding metastases might form a key to understanding the metastatic phenotype. In this study we aimed to characterize such differences using a genome‐wide screening measure.Methods.Four human cell lines (MDA‐686tu, MDA‐686Ln, MDA‐1386tu, MDA‐1386Ln) derived from primary tumor and synchronous lymph node metastasis of two cases of metastatic HNSCC were subjected to comparative genomic hybridization (CGH) by differentially labeling DNA from tumor tissue and normal tissue with fluorescent agents. The labeled DNAs were simultaneously hybridized onto normal metaphase chromosomes. In addition, modified CGH was performed by directly hybridizing labeled primary tumor DNA against differentially labeled metastatic tumor DNA, allowing the direct detection of copy number differences in individual pairs. Image analysis for fluorescence intensity along the entire length of each metaphase chromosome allowed generation of a color ratio, which was used to detect copy number changes.Results.In both cases, significant overlap was found between chromosomal aberrations present in the primary tumor and the corresponding nodal metastasis. However, several abnormalities differentiated primary tumors from their metastases. Modified CGH identified several genetic aberrations that were not detectable with the conventional CGH analysis. Gains at chromosomes 10p11‐12 and 11p and deletions at chromosomes 4q22‐31, 9p13‐24, and 14q differentiated nodal metastases from the corresponding primary tumors in both cases.Conclusions.The combination of conventional and modified CGH analyses facilitates the identification of DNA copy number changes that might be involved in the development of a metastatic phenotype. Future research should aim at the identification of the genes involved at the identified sites of chromosomal aberration. © 2004 Wiley Periodicals, Inc. Head Neck 26: 10–15, 2004
Sinonasal neuroendocrine carcinoma in association with SIADH
Authors: Vasan Nilesh R. , Medina Jesus E. , Canfield Vikki A. , Gillies Elizabeth M. 
Published: January 2004

AbstractBackground. Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer.Methods. We report a 30‐year‐old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy.Results. Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH.Conclusions. We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports. © 2004 Wiley Periodicals, Inc. Head Neck 26: 89–93, 2004
Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case
Authors: Del Gaudio John M. , Muller Susan 
Published: January 2004

AbstractBackground. Paragangliomas of the larynx are unusual tumors that are seen as a vascular submucosal mass. These usually are seen in the supraglottic larynx but have also been found in the subglottis. This is the only laryngeal neuroendocrine tumor with a female predilection. It is important that paragangliomas be differentiated from other neuroendocrine tumors of the larynx, including atypical carcinoid, because of differing treatment modalities.Methods. We present the clinical, radiologic, and pathologic findings of a supraglottic laryngeal paraganglioma seen in a 50‐year‐old woman with a 6‐month history of slowly progressive hoarseness.Results. The tumor was successfully approached by means of a midline laryngofissure with mucosal preservation. The patient remains disease free 24 months after surgery.Conclusions. Preoperative CT and angiography are useful in making the diagnosis of paraganglioma before surgical intervention. Complete excision through an external mucosa‐sparing approach is the treatment of choice. Distinguishing laryngeal paraganglioma from other neuroendocrine tumors can be difficult. Immunohistochemistry is an important tool for the correct pathologic diagnosis. © 2004 Wiley Periodicals, Inc. Head Neck 26: 94–98, 2004
Acinic cell carcinoma of the parotid gland presenting as an external auditory canal mass
Authors: Prasad Mukesh , Kraus Dennis H. 
Published: January 2004

AbstractBackground. The fissures of Santorini have long been known as a gateway for disease to pass from the external auditory canal to the periparotid and neck spaces. Although anatomically understandable, description of disease that originates in the parotid gland and extends through the fissures to the external auditory canal is rare. This is, in fact ,the first presentation of such a patient at our institution in a previously untreated patient.Case Report. A 43‐year‐old woman was seen with a mass in her right external auditory canal. Further evaluation found this to be the presenting finding of a parotid neoplasm. The patient also had a right marginal mandibular paresis. Biopsy of the external auditory canal mass provided a diagnosis of an acinic cell adenocarcinoma. She underwent a right lateral temporal bone resection, type III modified neck dissection, and radical parotidectomy with facial nerve sacrifice and rectus abdominus reconstruction with facial nerve grafting. Pathologic examination of the specimen revealed an acinic cell carcinoma of the right parotid gland with focal dedifferentiation into a high‐grade adenocarcinoma.Conclusions. Care should be taken with auditory canal masses to remember the possibility that disease is extending from the parotid through the fissures of Santorini, and evaluation and management should proceed accordingly. © 2004 Wiley Periodicals, Inc. Head Neck 26: 85–88, 2004
Longitudinal health‐related quality of life after mandibular resection for oral cancer: a comparison between rim and segment
Authors: Rogers Simon N. , Devine John , Lowe Derek , Shokar Parminder , Brown James S , Vaugman E. David 
Published: January 2004

AbstractBackground.Mandibular resection for oral cancer is often necessary to achieve an adequate margin of tumor clearance. Segmental mandibulectomy has been associated with a poor health‐related quality of life (HRQOL), particularly before composite free tissue transfer to reconstruct the defect. Little is published in the literature contrasting the subjective deficit of segmental compared with rim resection. The aim of this study was to use a validated head and neck HRQOL questionnaire to compare rim and segmental mandibular resection in patients having primary surgery for oral cancer.Method.There were 224 consecutive patients between 1995 and 1999 who were treated by primary surgery for oral squamous cell carcinoma. One hundred twenty‐tree had no mandibular resection, 44 had a rim resection, and 57 had a segmental resection. The University of Washington Quality of life questionnaire (UW‐QOL) was adminstered before treatment, at 6 months, 12 months and after 18 months.Results.Preoperatively, patients undergoing segmental resection reported significantly more pain, chewing problems, and a lower composite UW‐QOL score. Postperatively, the segment group tended to score worse at all time points, particularly in appearance, swallowing, recreation, and chewing; however, the difference between rim and segment was only seen in smaller resections without adjuvant radiotherapy. Little difference was seen between rim or segment for tumors <4 cm with radiotherapy and between rim and segments for tumors >4cm.Conclusion:After segmental mandibulectomy and reconstruction using composite free tissue transfer, the UW‐QOL scores were relatively good. The only 2 difference between rim and segments was noted in the small resections without radiotherapy, and some of this was reflected in differences at baseline. © 2004 Wiley Periodicals, Inc. Head Neck 26: 54–62, 2004.
Cancer of the oral cavity: a comparison between institutions in a developing and a developed nation
Authors: Carvalho André L. , Singh Bhuvanesh , Spiro Ronald H. , Kowalski Luiz P. , Shah Jatin P. 
Published: January 2004

AbstractBackground.The literature suggests that the natural history of squamous cell carcinoma of the oral cavity may vary and the prognosis is different in patients from developing and developed nations. The objective of this study was to compare the clinical presentation, management, and outcome of patients with oral cancer treated at tertiary care cancer institutions in a developing nation (Brazil— Centro de Tratamento e Pesquisa Hospital do Cancer A. C. Camargo [HCACC]) with those from a developed nation (United States— Memorial Sloan‐Kettering Cancer Center [MSKCC]).Methods.Between January 1990 and December 1994, 602 patients underwent initial treatment in the study institutions.Results.Overall, patients from HCACC had a higher predominance of men (78.8% vs 54.6%;p< .001) and a higher prevalence of tobacco (88.1% vs 77.8%;p= .002) and alcohol consumption (80.9% vs 69.8%;p= .004). More patients at HCACC had advanced disease (stage III/IV; 73.4% vs 37.4%;p< .001). Even though the overall outcome was poorer in patients from HCACC (p< .001), after controlling for stage, there was not a statistically significant difference in disease‐free or overall survival between the two institutions. Only at cancer‐specific survival for early‐stage disease (stage I/II) patients showed a difference (p= .05). Moreover, clinical stage (RR, 3.7; 95% CI, 2.6–5.5) and definitive treatment (RR, 3.3; 95% CI, 2.4–4.6) were the only factors that remained as significant predictors of outcome on multivariate analysis. Finally, the rate of subsequent second primary cancers was higher in patients from HCACC (p= .03).Conclusions.Statistically significant differences were found in clinical presentation, tumor characteristics, and outcome in OC patients between the two institutions from a developing and developed nation. Overall outcome was poorer in HACC patients. However, after controlling for site, stage, and treatment, the outcome of these patients was similar, with the exception of a higher rate of occurrence of second primary cancers in patients from HACC. Given that the use of standard protocols of treatment offer similar outcomes, the establishment of education programs and screening measures for early diagnosis might be the best chance to improve overall outcome in OC patients in developing nations. © 2004 Wiley Periodicals, Inc.Head Neck26:31–38, 2004
Sentinel lymph node biopsy in oral cavity squamous cell carcinoma without clinically evident metastasis
Authors: Kontio Risto , Leivo I. , Leppänen E. , Atula T. 
Published: January 2004

AbstractBackground.The clinically N0 neck in patients with oral SCC is commonly treated by neck dissection because the existence of metastases cannot be excluded. To determine whether unnecessary treatment could be avoided, we evaluated the feasibility of sentinel lymph node (SLN) biopsy.Methods.Fifteen previously untreated patients with T1 or T2 oral SCC without clinically or radiologically detectable metastasis were included. A blue dye and gamma probe were used to identify SLNs. SLNs were stained with cytokeratins. All nodes in neck dissection specimens were stained using H & E.Results.SLNs were identified in 14 patients by lymphoscintigraphy and in all patients when probe and dye were combined. Four neck dissection specimens contained four metastatic lymph nodes. Three of the four lymph nodes were SLN. One SLN was found to be metastatic after immunostaining. However, although there was one blue sentinel node in one neck, a metastatic non‐SLN was present.Conclusions.Our results show that SLN biopsy is a promising tool for use in patients with oral SCC. However, further studies are necessary. © 2004 Wiley Periodicals, Inc. Head Neck 26: 16–21, 2004
Clinical outcomes for the elderly patient receiving a tracheotomy
Authors: Baskin Jonathan Zvi , Panagopoulos Georgia , Parks Christine , Rothstein Stephen , Komisar Arnold 
Published: January 2004

AbstractBackground.Tracheotomies are routinely performed for severely ill and elderly patients with respiratory failure. This intervention is questioned, given the poor survival rate in this group. Outcomes analysis is performed after tracheotomy.Methods.This is a retrospective study of 78 elderly patients, who received tracheotomies for respiratory failure. Pretracheotomy data (age, length of oral intubation, and DNR status) were collected. Outcomes analyzed during the same admission as the tracheotomy included death versus discharge, ventilator dependence, vocal function, route of feeding, decannulation, and ICU discharge disposition.Results.The mean age was 77.6 ± 11 years (median, 79 years) and patients were intubated for 16.7 ± 9 days. Forty‐two percent (n = 33) obtained DNR orders after tracheotomy, and 8% (n = 6) before tracheotomy. Seventy‐one percent of patients (n = 55) had gastrostomy tubes placed. Fifty‐six percent of patients (n = 44) died after tracheotomy; median time from tracheotomy to death was 31 days. After tracheotomy, 53 % (n = 41) remained at least partially ventilator dependent, 18 % (n = 14) regained consistent vocal function, and 13 % (n = 10) were decannulated. For those who died, 27 % (n = 12) died without leaving the ICU.Conclusion.These data demonstrate that a large proportion of elderly, severely ill patients with respiratory failure suffer poor outcomes after tracheotomy. More stringent criteria are necessary for performing the tracheotomy in this patient population. © 2004 Wiley Periodicals, Inc. Head Neck 26: 71–76, 2004.
DNA bulky adducts in a Mediterranean population correlate with environmental ozone concentration, an indicator of photochemical smog
Authors: Palli Domenico , Saieva Calogero , Grechi Daniele , Masala Giovanna , Zanna Ines , Barbaro Antongiulio , Decarli Adriano , Munnia Armelle , Peluso Marco 
Published: January 2004

AbstractOzone (O3), the major oxidant component in photochemical smog, mostly derives from photolysis of nitrogen dioxide. O3 may have biologic effects directly and/or via free radicals reacting with other primary pollutants and has been reported to influence daily mortality and to increase lung cancer risk. Although DNA damage may be caused by ozone itself, only other photochemical reaction products (as oxidised polycyclic aromatic hydrocarbons) may form bulky DNA adducts, a reliable biomarker of genotoxic damage and cancer risk, showing a seasonal trend. In a large series consisting of 320 residents in the metropolitan area of Florence, Italy, enrolled in a prospective study for the period 1993–1998 (206 randomly sampled volunteers, 114 traffic‐exposed workers), we investigated the correlation between individual levels of DNA bulky adducts and a cumulative O3 exposure score. The average O3 concentrations were calculated for different time windows (0–5 to 0–90 days) prior to blood drawing for each participant, based on daily measurements provided by the local monitoring system. Significant correlations between DNA adduct levels and O3 cumulative exposure scores in the last 2–8 weeks before enrollment emerged in never smokers. Correlations were highest in the subgroup of never smokers residing in the urban area and not occupationally exposed to vehicle traffic pollution, with peak values for average concentrations 4–6 weeks before enrollment (r = 0.34). Our current findings indicate that DNA adduct formation may be modulated by individual characteristics and by the cumulative exposure to environmental levels of ozone in the last 4–6 weeks, possibly through ozone‐associated reactive pollutants. © 2003 Wiley‐Liss, Inc.
Spatial Distribution and Coexistence Patterns of Caddisfly Larvae (Trichoptera) in a Hungarian Stream
Authors: Schmera Dénes 
Published: January 2004

AbstractIt is well known that stream macroinvertebrates usually show aggregated spatial distributions caused by extrinsic factors and interactions among species and individuals. In the present study, the spatial distribution of caddisfly assemblages and coexistence patterns of larval caddisfly species (Insecta: Trichoptera) were measured in a Hungarian stream reach at three different spatial scales.Caddisfly assemblages showed aggregated, random and regular distributions as measured by the variance‐mean relationship of species richness as sampling area increased from 0.0225 m2 to 0.2025 m2. The observed coexistence patterns indicated interactions (lower diversity of unique species combinations than expected by chance) among species for aggregated distributions. These interactions among species proved to be positive associations particularly among species belonging to the same functional feeding group.The positive associations and the aggregated distribution of caddisflies supported the hypothesis that microhabitat patches (patchy microhabitat‐macroinvertebrate model) and/or positive biological interactions among species using the same resource (hypothesis of facilitation) have a deterministic effect on the spatial distribution of caddisfly assemblages. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)