bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Methods of Conducting Transactions Using Digital Technologies
Authors: Savelyeva T. A. 
Published: December 2023

Objective: to substantiate the need to identify new contractual constructs (models) taking into account the specific relations associated with the use of remote method of contract conclusion through digital technologies and to study the possible risks for their participants.Methods: along with special legal methods, the method of critical analysis was fundamental for the research process, which allowed us to evaluate and interpret the main sources and norms of civil law in relation to distant transactions. It also allowed assessing the current state of legislation in this area in the context of developing processes of digitalization and technologization of civil-law relations.Results: a critical analysis of the current state of legal regulation of remote ways of concluding contracts is presented, their classification is given. It is concluded that the digital technologies development gives rise to new remote ways of transactions, as well as fills with new content the procedures of contract conclusion, traditional for civil law. The expediency of singling out the concept of a “distant transaction” as a legal category in order to create a special civil-law regime is substantiated, and the basic concept being that of a “distant contract”. Certain types of distant contracts are analyzed to substantiate the need for special legal regimes in cases when the distant method of contract conclusion is combined with the use of digital technologies. It poses such problems as the distribution of risks of technological failures, hacker attacks, compliance with the balance of interests of the parties taking into account information asymmetry, and the need to protect the weaker party.Scientific novelty: an attempt is made to define such concepts as a “distant contract” and a “distant transaction” and to identify their features. The expediency is substantiated of considering a distant contract as a separate legal construction (model) of the contract. Within this framework, a special legal regime should be developed and fixed, which can be extended to unilateral distant transactions. The problems of legal regulation caused by the use of information technologies are formulated, and legal constructions for their solution are proposed.Practical significance: the final conclusions and proposals can be used both in contractual practice by the participants of civil turnover and for the normative consolidation of the concept and features of “distant contract”, “distant transaction”. A special legal regime can be created, taking into account the specificity generated by the use of digital technologies.
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma
Authors: Jain Rakesh , Krishnan Shanmugarajan , Lee Somin , Amoozgar Zohreh , Subudhi Sonu , Kumar Ashwin , Posada Jessica , Lindeman Neal , Lei Pinji , Duquette Mark , Roberge Sylvie , Huang Peigen , Andersson Patrik , Datta Meenal , Munn Lance , Fukumura Dai 
Published: December 2023

Abstract
Wnt signaling plays a critical role in the progression and treatment outcome of glioblastoma (GBM). Here, we identified WNT7b as a heretofore unknown mechanism of resistance to immune checkpoint inhibition (αPD1) in GBM patients and murine models. Acquired resistance to αPD1 was found to be associated with the upregulation of Wnt7b and β-catenin protein levels in GBM in patients and in a clinically relevant, stem-rich GBM model. Combining the porcupine inhibitor WNT974 with αPD1 prolonged the survival of GBM-bearing mice. However, this combination had a dichotomous response, with a subset of tumors showing refractoriness. WNT974 and αPD1 expanded a subset of DC3-like dendritic cells (DCs) and decreased the granulocytic myeloid-derived suppressor cells (gMDSCs) in the tumor microenvironment (TME). By contrast, monocytic MDSCs (mMDSCs) increased, while T-cell infiltration remained unchanged, suggesting potential TME-mediated resistance. Our preclinical findings warrant the testing of Wnt7b/β-catenin combined with αPD1 in GBM patients with elevated Wnt7b/β-catenin signaling.
Synthetic Mn3Ce2O5-Cluster Mimicking the Structure and Function of the Oxygen-Evolving Center in Photosynthesis
Authors: Zhang Chunxi , Chen Yang , Su Yao , Han Juanjuan , Chen Changhui , Fan Hong-Jun 
Published: December 2023

Abstract
The photosynthetic oxygen-evolving center (OEC) is a unique Mn4CaO5-cluster that catalyses the water-splitting reaction in nature. It is a long-standing challenge to precisely mimic the structure and function of the OEC in the laboratory. Herein we report two synthetic Mn3Ce2O5-clusters that display unprecedented similarities to the OEC regarding the ten-atom core and the alkyl carboxylate peripheral ligands, as well as the catalytic capability of the water-splitting reaction in aqueous solution. In addition, it has been shown that the oxide bridge in the cluster can rapidly exchange with the isotopic oxygen of H218O in solution. These results, for the first time, demonstrate that cerium can structurally and functionally replace both the calcium and one manganese in the cluster. Our data provide chemical evidence that the oxide bridge could be directly involved in the O-O bond formation in its biological paragon and shed new light on the design of water-splitting catalysts in future.
High Frequency of Alpha7-HPV in Colombian Caribbean Coast Women: Cervical Cancer Screening Analysis
Authors: Aretaga-Pautt Heiser , Leon Sara Cecilia Soto-De , Castano-Caraballo Lorena , Perdomo-Lara Sandra Janeth , Zetien-Arteaga Helvey Ramon , Ricardo-Caldera Dina , Espitia-Pérez Lyda , Avilés-Vergara Paula A. , Tovar-Acero Catalina , Behaine-Bravo Valentina , Bru-Cordero O. Elias 
Published: December 2023

Abstract
Background
Cervical cancer (CC) is a significant global public health concern, particularly in developing countries such as Colombia. The main risk factor involves high-risk HPV types (HR-HPV) infection, coupled with population-specific variables. The Caribbean region in Colombia lacks research on HR-HPV-type frequencies. Therefore, this study aims to establish the prevalence of type-specific HR-HPV and its association with sociodemographic factors among women undergoing cervical cytology screening.
Methods
A cross-sectional study involving voluntary women who provided informed consent and completed a questionnaire capturing sociodemographic, clinical, and sexual behavior information was conducted. All participants underwent cervical cytology and molecular analysis. Generic HPV detection employed three simultaneous PCRs (GP5+/6+, MY09/11, and PU1R/2M), and positive samples were genotyped using the Optiplex HPV Genotyping kit. The analysis encompassed the 12 types of high-risk HPV (HR-HPV-16,-18,-31,-33,-35,-39,-45,-51,-52,-56,-58, and − 59). Frequencies were reported based on geographic subregions within the Córdoba department, and disparities were made between single and multiple infections. Sociodemographic and clinical variables were subjected to multinomial logistic regression, with statistical significance at a p-value < 0.05. The statistical analyses utilized STATA 14® and R-Core Team-software.
Results
We included 450 women, mean age 40 (SD\(\pm\)11.44). PCR analysis revealed 43% HPV-positive (n=192). GP5+/6+ detected the most positives at 26% (n=119), followed by PU1R/2M at 22% (n = 100) and MY09/11 at 15% (n=69). Multiple infections occurred in 87.3% (n=142), primarily 2 to 4 types (47.37%, n=90). Dominant types were HPV-18 (15.6%, n=61), HPV-16 (14.9%, n=58), HPV-31 (13.0%, n = 51), and HPV-45 (11.5%, n=45). Logistic regression identified age above 60 as a risk for concurrent multiple types (OR=6.10; 95% CI 1.18–31.63). Menopause was protective (OR=0.31; 95% CI 0.11–0.89).
Conclusions
Our study reveals a notable prevalence of multiple (2–4) high-risk HPV infections among adult women engaged in CC detection initiatives. Predominantly, α7 species constitute the prevalent HR-viral types, with the Medio Sinú subregion showing elevated prevalence. Menopausal status confers protection against diverse HR-HPV infections. Nevertheless, advancing age, particularly beyond 60 years, is linked to an increased susceptibility to simultaneous infections by multiple HPV-types.
Born with Two Faces: Sequential development of Diffuse Large B-cell Lymphoma and Angioimmunoblastic T-cell Lymphoma with EBV positive and TET2 mutation
Authors: Li Qing , Dai Shishuo , Liu Weiping , Wu Yu 
Published: December 2023

Abstract
There may be significant histopathological and pathogenetic overlap between Epstein–Barr virus (EBV) -positive diffuse large B cell lymphoma (DLBCL) and other lymphomas, including angioimmunoblastic T-cell lymphoma (AITL). Herein, we reported a rare case of an AITL developing two years after the initial diagnosis of EBV-positive DLBCL. Next-generation sequencing (NGS) is used to study genetic mutations in biopsy samples of DLBCL and subsequent AITL. NGS revealed that TET2 mutated in both DLBCL and AITL, while other differential mutations were also detected, reflecting their own characteristics. Since inherent EBV infection plays a role in both AITL and DLBCL, we evaluated the characteristics of lymphoma associated with EBV infection, including morphology and treatment, etc. We deduce that chronic EBV infection and epigenetic TET2 mutations may alter the immune profile or tumor microenvironment of lymphoma cells, resulting in patients presenting with different tumor types at different times. Patients with AITL secondary to DLBCL have a poor prognosis, and the combination of chidamide and chemotherapy is expected to provide new treatment options for these patients, mainly due to the multiplex antitumor mechanism of chidamide in lymphoma.
Strategically dewaxed honeycomb powder is a promising and eco-friendly alternative for the removal of malachite green through fixed bed column
Authors: Kumari Roshni , Khan Md. Adnan , Mahto Mithilesh , Qaiyum Md. Atif , Mohanta Jhilirani , Dey Banashree , Samal Priyanka Priyadarsini , Sambasivaiah B. , Dey Soumen 
Published: December 2023

Abstract

A fixed-bed column study for the removal of malachite green (MG) from the aqueous phase was demonstrated using strategically dewaxed honeycomb powder (HCP). The removal efficiency was tested at several working column parameters such as column bed height, initial dye concentration, working pH, and flow rate. Breakthrough curves have been plotted using throughput volume versus concentration ratio for different parameters to identify the pathway of uptake. Thomas and BDST kinetic models have been exercised to obtain rate constants and uptake capacity. BDST model suggests an adsorption capacity of 196.28 mg/L. The column performance was seen to vary with solution pH and was found favorable at higher pH.The adsorption rate decreases with increasing flow rate but increases with increasing concentration of the dye. Easy regeneration ensures multi-cycle operations. The mechanism of dye adsorption by HCP has been proposed to be a blend of electrostatic attraction and weak forces. Henceforth the use of HCP for removal of MG in column mode may be extrapolated to serve as a promisingagent in the treatment of dye-containing water and wastewater.
Development and validation of a risk prediction model for frailty in patients with chronic diseases
Authors: wang yaling , xu yuanchun , cao wei , he zongsheng , wu nuoyi , cai mingyu , yang li , liu shuying , jia wangping , he haiyan 
Published: December 2023

Abstract

Background
The occurrence rate of frailty is high among patients with chronic diseases. However, the assessment of frailty among these patients is still far from being a routine part of clinical practice. The aim of this study is to develop a validated predictive model for assessing frailty risk in patients with chronic illnesses.
Methods
This study utilized survey data from elderly chronic disease patients (aged ≥ 60 years) at a tertiary hospital in China between 2022 and 2023. A total of 57 indicators were analyzed, encompassing sociodemographic variables, health status, physical measurements, nutritional assessment, physical activity levels, and blood biomarkers. The research cohort was randomly divided into training and validation sets at a ratio of 70–30%. Employing LASSO regression analysis, the study selected the optimal predictive factors based on univariate analysis. Logistic regression models were applied to investigate factors associated with frailty in chronic disease patients. A nomogram was constructed to establish the predictive model. The predictive performance of the model was evaluated using the area under the receiver operating characteristic curve, calibration curves, and decision curve analysis.
Results
This study recruited a total of 543 patients with chronic diseases, among which 237 were included in the development and validation of the predictive model. There were 100 cases (42.2%) presenting frailty symptoms. Multivariate logistic regression analysis revealed that gender, age, chronic diseases, Mini Nutritional Assessment (MNA) score, and Clinical Frailty Scale (CFS) score were predictive factors for frailty in chronic disease patients. Utilizing these factors, a nomogram model demonstrated good consistency and accuracy. The AUC values for the predictive model and validation set were 0.946 and 0.945, respectively. Calibration curves, ROC, and DCA indicated the nomogram had favorable predictive performance.
Conclusions
The comprehensive nomogram developed in this study is a promising and convenient tool for assessing frailty risk in patients with chronic diseases, aiding clinical practitioners in screening high-risk populations.
Registration: ChICTR2300068076 (first recruitment date was 2022/07/06)
Development of a deep learning algorithm to estimate knee adduction moment during gait using a single inertial measurement unit
Authors: Akiba Ayako , Harato Kengo , Yoshihara Hiroshi , Iwama Yu , Nishizawa Kohei , Nagura Takeo , Nakamura Masaya 
Published: December 2023

Abstract
Background: The external knee adduction moment (KAM) during gait is known as a digital biomarker for knee osteoarthritis (KOA). Three-dimensional motion capture system has been used to measure KAM, but it has limitations to measure KAM in cost, measuring time and space.
Purpose: To developed a simple and wearable system to estimate KAM, which can be used in daily practice. For this purpose, a deep learning algorithm was developed to estimate KAM of KOA using data from a single inertial measurement unit on the knee.
Study Design: Cross-Sectional Study. Level 3
Methods: Fifty female and ten male subjects who diagnosed as having KOA were included to develop an AI system. Simultaneous measurements of 5m walk using 3D motion capture and IMU attached on the knee were performed, and a deep learning algorithm was developed base on gait phase detection algorithm and 1D Convolutional Neural Network (CNN) model. Reliability of the AI system was evaluated by 5m gait data of another 13 KOA and 7 asymptomatic subjects.
Results: The mean absolute percent error (MAPE) and the mean absolute error (MAE) of estimated KAM peak of training data set and test data set were 13.0% and 0.0428 Nm.s/(BW*Ht), and 17.3% and 0.0505Nm.s/(BW*Ht) respectively, and those of estimated KAM impulse were 20.4% and 0.0214 Nm.s/(BW*Ht), and 21.4% and 0.0212 Nm.s/(BW*Ht) respectively. Peason’s correlation coefficients between estimated KAM (peak, impulse) and true KAM (peak, impulse) were 0.870 and 0.975 in train data set, and those in the test data set were 0.591 and 0.690. The intraclass correlation coefficients (ICCs) of estimated KAM impulse were 0.83, 0.94, 0.70 and 0.82, for ICCs (1.1), (1,k), (2,1) and (2,k) respectively.
Conclusions:
Using gait phase detection algorithm and 1D-CNN, we have successfully obtained the acceleration parameters (iKAM) from a single IMU data, and the acceleration parameters showed reasonable accuracy and reliability in estimating KAM. We require only single sensor on each knee which needs less calculation and hardware cost. Simple equipment of our system enables us to measure KAM during daily practice at clinic or hospital if there is free space to walk 5m.
Alteration of prefrontal cortex and its associations with emotional and cognitive dysfunctions in adolescent borderline personality disorder
Authors: Xiao Qian , Shen Liying , He Haoling , Wang Xueying , Fu Yan , Ding Jun , Jiang Furong , Zhang Jinfan , Zhang Zhejia , Yi Xiaoping , Chen Bihong T. 
Published: December 2023

Abstract

Background
The neurobiological mechanism of borderline personality disorder (BPD) in adolescents remains unclear. The study aimed to assess the alterations in neural activity within prefrontal cortex in adolescents with BPD and investigate the relationship of prefrontal activity with cognitive function and emotional regulation.
Methods
This study enrolled 50 adolescents aged 12–17 years with BPD and 21 gender and age-matched healthy control (HC) participants. Study assessment for each participant included a brain resting-state functional MRI (rs-fMRI), cognitive testing with Stroop Color-Word Test (SCWT) and clinical assessment questionnaires such as Borderline Personality Features Scale (BPFS), Difficulties in Emotion Regulation Scale (DERS), Ottawa Self-Injury Inventory and Childhood Trauma Questionnaire (CTQ). Fractional amplitude of low-frequency fluctuations (fALFF) and seed-based functional connectivity (FC) were obtained from rs-fMRI analysis. Correlative analysis was also performed to evaluate the associations of the neuroimaging metrics such as fALFF and FC with cognitive testing scores and clinical assessment questionnaire scores.
Results
Adolescents with BPD showed increased fALFF values in the right inferior frontal gyrus and decreased activity in the left middle frontal gyrus as compared to the HC group (p < 0.05, cluster size ≥ 100, FWE correction). In adolescents with BPD, the reduced fALFF in the left middle frontal gyrus was associated with SCWT-A (reading characters) and SCWT-B (reading color). Increased fALFF in the right inferior frontal gyrus was related to BPFS, DERS-F and Ottawa Self-Injury Inventory-4C. Additionally, both the fALFF values in the left middle frontal gyrus and the right inferior frontal gyrus were related to the CTQ-D (emotional neglect) (p < 0.05). The left middle frontal gyrus exhibited increased FC with the right hippocampus, left inferior temporal gyrus and right inferior frontal gyrus (voxel p < 0.001, cluster p < 0.05, FWE correction). The increased FC between the left middle frontal gyrus and the right hippocampus was related to SCWT-C (cognitive flexibility).
Conclusions
We observed diverging changes in intrinsic brain activity in prefrontal cortex, and neural compensatory FC changes to maintain function in adolescents with BPD. In addition, increased neural function as indicated by brain activity and FC was associated with cognitive dysfunction, while decreased neural function was closely associated with emotional dysregulation. These results indicated that alterations of intrinsic brain activity may be one of the underlying neurobiological markers for clinical symptoms in adolescents with BPD.
A case study of furunculosis following an Ayurvedic oil massage and sudation therapy, and lessons to learn
Authors: Kulkarni Satyajit P , Kulkarni Pallavi S , S Kumar 
Published: December 2023

Abstract
India has a long history of using sudation therapy and oil massage as Ayurvedic treatments. However, nothing is known about its side effects, and just two studies have identified side effects as cutaneous Adverse Drug Reactions brought on by Ayurvedic oil massage. We are presenting the example of a 72-year-old adult man who visited our hospital and had his right knee massaged with Nirgudi oil. Erythema, papules, itchiness, and scorching pain were some of his symptoms. However, these sensations only partially abated once we quit massaging. Our investigation demonstrates that the skin reaction associated with furunculosis is brought on by a Nirgudi oil massage or sudation. This case report illustrates the necessity to be aware of Panchakarma-related consequences and suggests that medical practitioners, patients, and product makers take into account the likelihood of such a reaction following Nirgudi oil massage and sudation therapy as a precaution.
PENGARUH PINJAMAN MODAL USAHA DAN PENDAMPINGAN USAHA TERHADAP PENDAPATAN UMKM
Authors: Prasetyo Candra , Firdaus Muhammad Anang , Karman Abd 
Published: December 2023

Abstrak: Modal usaha sangat berpengaruh bagi bertambahnya pendapatan UMKM, diharapkan dengan modal usaha UMKM dapat mengembangkan usahanya dengan mengikuti perkembangan zaman yang ada. Dengan modal usaha juga UMKM bisa berinovasi dengan usahanya sehingga menambah pendapatan. Tidak hanya modal usaha saja, pendampingan kepada para UMKM juga mesti dilakukan demi menangani kasus yang dilalui oleh UMKM sendiri, pendampingan juga berguna untuk membuka pengetahuan baru bagi UMKM yang kurang baik dalam pengelolaannya. Pendekatan penelitian yang dikenakan dalam riset ini merupakan pendekatan riset kuantitatif menggunakan SPSS sebagai alat analisis. Pinjaman modal mempengaruhi secara signifikan peningkatan Pendapatan UMKM. Variabel pendampingan usaha juga mempengaruhi secara signifikan peningkatan Pendapatan UMKM. Variabel independen yakni pinjaman modal serta pendampingan usaha mempengaruhi secara simultan terhadap Pendapatan UMKM.
Kata Kunci: Pinjaman Modal; Pendampingan; Pendapatan; UMKM.

Abstract: Business capital has a significant impact on the increase in UMKM income. It is expected that with business capital, UMKM can develop its businesses by following the current trends. With business capital, UMKM can also innovate their businesses to increase income. Not only business capital but mentoring for UMKM must also be carried out to handle cases faced by UMKM themselves, mentoring is also useful to open up new knowledge for UMKM that is not good in management. The research approach used in this research is a quantitative research approach using SPSS as an analysis tool. Loan capital significantly affects the increase in UMKM income. The business mentoring variable also significantly affects the increase in UMKM income. The independent variables, namely loan capital and business mentoring, simultaneously affect UMKM income.
Keywords: Capital loan; Mentoring; Income; MSM.
A review on sources of uncertainties for groundwater recharge estimates: insight into data scarce tropical, arid, and semiarid regions
Authors: Beyene Tsegamlak Diriba , Zimale Fasikaw Atanaw , Gebrekristos Sirak Tekleab 
Published: December 2023

Abstract
Successful sustainable groundwater management requires accurate information on recharge for a given aquifer system. However, recharge estimates are usually used in relative terms rather than an absolute sense. A review of available studies on groundwater recharge estimate uncertainty as well as tools for uncertainty analysis was conducted. Nonetheless, except for the handful of studies that have conducted proper uncertainty analysis, most were inclined to implement multiple methods as an indication of the range of uncertainty. The global trend indicates that considering the significant number of methods for recharge estimation, very little has been done to assess the uncertainty of each method. Therefore, more attention should be given to the individual uncertainty analysis of selected methods as much as using multiple methods recommended for investigating uncertainty. Insight from the review indicates that, when used carefully, tracer-based analysis can be effective and coupling is required for uncertainty analysis. Furthermore, spatial uncertainty due to input data could potentially be minimized by using input data from multiple sources. Better conceptualization of the hydrogeological process can reduce the uncertainty of numerical modelling. This review is limited to widely used methods and excludes uncertainty due to inappropriate method implementation and controlled experimental uncertainties.