bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Right Bundle Branch Block in Acute Coronary Syndrome with ST Segment Elevation: Epidemiological Features
Authors: ZOUZOU Hanane 
Published: October 2023

Background: Complete right bundle branch in acute coronary syndrome with ST segment elevation is common and may predict a poor clinical prognosis.
Its incidence has been the subject of several international studies, as well as, its related mortality, but its epidemiological data is lacking in Algeria.
Aims: The main objective of our study is the determination of the frequency of complete right bundle branch block in acute coronary syndrome with ST segment elevation, the secondary objective was the analysis of its predictive factors and related mortality.
Methods and materials: In this prospective study, conducted in the cardiology department of Hussein Dey hospital (Algiers-Algeria), 467 patients with acute coronary syndrome with elevated ST segment (87 women and 380 men) were enrolled between 28 February 2014 and 16 July 2015. The average age is 60 ± 13 years; at admission, a Holter recorder was attached for continuous ECG monitoring during 48 hours.
Kruskal’s ANNOVA or H tests were used for comparison of quantitative variables, χ2 test or Fisher’s exact test, were used for qualitative variables, all tests were performed with 1st species risk of 5%.
Results: The frequency of complete right bundle brunch block is 10.9 % (51 patients), CI 95%: [8.1%-13.7%], multivariate analysis identified the following independent predictors: anterior acute coronary syndrome, persistence of chest pain after thrombolysis, and diabetes type 2.
The risk of mortality expressed by Hazard Ration (HR) is 3.4, CI95%: [1.07-11.35], p = 0.037; persistence of ST segment elevation after thrombolysis is the only predictive factor of mortality, identified in our study.
Conclusion: Complete right bundle brunch block is frequent in acute coronary syndrome with elevated ST segment, its predictive factors according to our study are: anterior acute coronary syndrome, persistence of chest pain after thrombolysis, and type 2 diabetes.
Its occurrence increases the risk of in-hospital mortality, and the predictor of this latter is the failure of thrombolysis.
Kearifan Sosiokultural: Hulu Moderasi Beragama Pesantren Bersama Masyarakat Adat Di Kalimantan Timur
Authors: Mubarak Mubarak , Yuspa Anida 
Published: October 2023

AbstractPesantren is a social resource is a cultural maintenance in the community. The linkage of pesantren in the role of society gives birth to ideological and historical continuity with the community. PPKP Ribathul Khail is the oldest Islamic boarding school in Tenggarong City, Kutai Kartanegara Regency, East Kalimantan Province, which lives with the indigenous people of Kutai Kraton, which is identical with the dimensions of belief, traditional rituals, and cultural expression. In its religious reality, PPKP Ribathul Khail is faced with the choice of sowing moderate religious values, tolerance within the framework of pluralism, and being at the forefront of improving the quality of life of the community through Islamic education activities carried out. His acceptance of the Kutai Kraton Ethnic in traditional rituals manifests his tolerance and moderation attitude that is present because of the view of sociocultural wisdom. This paper is the result of field research that attempts to present data on the sociocultural wisdom of pesantren as the upstream of religious moderation and its various dynamics to create a sustainable relationship with the indigenous people of Kutai Kraton in East Kalimantan.Keywords: Sociocultural Wisdom, Religious Moderation, Indigenous Peoples of Kutai Kraton AbstrakPesantren sebagai sumberdaya sosial menjadi pemelihara budaya di masyarakat. Keterkaitan pesantren dalam peranan kemasyarakatan melahirkan kesinambungan ideologi dan historis bersama masyarakat. PPKP Ribathul Khail adalah pesantren tertua di Kota Tenggarong, Kabupaten Kutai Kartanegara, Provinsi Kalimantan Timur, yang hidup bersama masyarakat adat Kutai Kraton, yang identik dengan dimensi kepercayaan, ritual adat, dan ekspresi berbudaya. Dalam realitas keberagamaannya, PPKP Ribathul Khail dihadapkan dengan pilihan mampu menyemai nilai-nilai keberagamaan yang moderat, bertoleransi dalam bingkai kemajemukan, serta menjadi garda terdepan dalam meningkatkan kualitas hidup masyarakat melalui kegiatan pendidikan Islam yang dilakukan. Penerimaannya terhadap Etnis Kutai Kraton dalam ritual adat, merupakan perwujudan sikap toleransi dan moderatnya yang hadir karena pandangan kearifan sosiokutural. Tulisan ini adalah hasil penelitian lapangan yang berupaya memaparkan data tentang kearifan sosiokultural pesantren sebagai hulu moderasi beragama, dan berbagai dinamikanya untuk menciptakan kesinambungan relasinya dengan masyarakat adat Kutai Kraton di Kalimantan Timur.Kata Kunci: Kearifan Sosiokultural, Moderasi Beragama, Masyarakat Adat Kutai Kraton
Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity
Authors: Zaryouh Hannah , Pauw Ines De , Baysal Hasan , Melis Jöran , Bossche Valentin Van den , Hermans Christophe , Lau Ho Wa , Lambrechts Hilde , Merlin Céline , Corbet Cyril , Peeters Marc , Vermorken Jan Baptist , Waele Jorrit De , Lardon Filip , Wouters An 
Published: October 2023

Aim: Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma (HNSCC). To accurately study novel combination treatments, suitable preclinical mouse models for cetuximab resistance are key yet currently limited. This study aimed to optimize an acquired cetuximab-resistant mouse model, with preservation of the innate immunity, ensuring intact antibody-dependent cellular cytotoxicity (ADCC) functionality.
Methods: Cetuximab-sensitive and acquired-resistant HNSCC cell lines, generated in vitro , were subcutaneously engrafted in Rag2 knock-out (KO), BALB/c Nude and CB17 Scid mice with/without Matrigel or Geltrex. Once tumor growth was established, mice were intraperitoneally injected twice a week with cetuximab for a maximum of 3 weeks. In addition, immunohistochemistry was used to evaluate the tumor and its microenvironment.
Results: Despite several adjustments in cell number, cell lines and the addition of Matrigel, Rag2 KO and BALB/C Nude mice proved to be unsuitable for xenografting our HNSCC cell lines. Durable tumor growth of resistant SC263-R cells could be induced in CB17 Scid mice. However, these cells had lost their resistance phenotype in vivo . Immunohistochemistry revealed a high infiltration of macrophages in cetuximab-treated SC263-R tumors. FaDu-S and FaDu-R cells successfully engrafted into CB17 Scid mice and maintained their sensitivity/resistance to cetuximab.
Conclusion: We have established in vivo HNSCC mouse models with intact ADCC functionality for cetuximab resistance and sensitivity using the FaDu-R and FaDu-S cell lines, respectively. These models serve as valuable tools for investigating cetuximab resistance mechanisms and exploring novel drug combination strategies.
Don Francisco Fernández de Córdoba, Abad de Rute.
Authors: Durán Rodríguez Domingo 
Published: October 2023

DON FRANCISCO FERNÁNDEZ DE CÓRDOBA, ABAD DE RUTEResumen: En este trabajo abordamos la figura de D. Francisco Fernández de Córdoba, el Abad de Rute, admirado historiador, genealogista, erudito humanista y experto arqueólogo. Participó de manera activa en la polémica suscitada por la aparición de las Soledades de Góngora, su amigo y ambos racioneros en la Catedral de Córdoba, siempre en defensa del nuevo estilo poético que iniciaba D. Luis. Perteneciente a la gran casa de los Fernández de Córdoba ya que era hijo ilegítimo de D. Luis Fernández de Córdoba, señor de la Zubia. Se recogen datos de su biografía aunque existen muchas lagunas documentales para completarla. Palabras clave: Abad de Rute, Fernández de Córdoba, gongorismo, erudición, Arqueología, cartas. DON FRANCISCO FERNÁNDEZ DE CÓRDOBA, ABBOT OF RUTE.Abstract: In this work we approach the figure of D. Francisco Fernández de Córdoba, the Abbot of Rute, admired historian, genealogist, scholarly humanist and expert archaeologist. He participated actively in the controversy aroused by the appearance of Soledades de Góngora, his friend and both racioneros in the Cathedral of Córdoba, always in defense of the new poetic style that D. Luis initiated. Belonging to the great family of the Fernández de Córdoba since he was the illegitimate son of D. Luis Fernández de Córdoba, the lord of the Zubia. Data is collected from his biography although there are many documentary gaps to complete it. Key words: Abbot of Rute, Fernández de Córdoba, gongorismo, erudition, Archeology, letters.
El matrimonio y los judeoconversos de la mesocracia cordobesa durante el siglo XV
Authors: Herencia Lavirgen Mª Inmaculada 
Published: October 2023

RESUMEN: Este trabajo trata de analizar las posibilidades y las dificultades que presenta el estudio de la documentación notarial del siglo XV, para, en base a esto, conocer las relaciones sociales tejidas entre los judeoconversos de la mesocracia cordobesa a través del matrimonio. Prestaremos atención a los problemas de la documentación, la participación de las familias, la composición de los matrimonios y su distribución por la ciudad; finalmente, ofreceremos el estudio de un caso concreto. No obstante, esto no es más que un primer paso en un trabajo que requiere mucha mayor profundidad; lo que presentamos aquí son las líneas de actuación a desarrollar con posterioridad.PALABRAS CLAVE: judeoconversos, mesocracia, redes, matrimonio. ABSTRACT: This paper focuses on the opportunities and the troubles that we find when we research about the notarial documents from the fifteenth century. With this base, we will be able to know that converts from Córdoba’s medium groups built new social networks by marriage. We will pay attention to the troubles we have found with documents, the role performed by families, the composition of the couples and their geographical setting in the city; finally, we will provide the analysis of a particular case. However, this is the first step of a research that requires more work, so what we offer here are the lines we will have to carry out later.KEY WORDS: converts, medium groups, networks, marriage.
The relations between working from home and travel behaviour: a panel analysis
Authors: Faber Roeland Martijn , Hamersma Marije , Brimaire Jil , Kroesen Maarten , Molin Eric J.E. 
Published: October 2023

Abstract
Policies to increase the amount of time people spend working from home were widely used during the COVID-19 pandemic. Since research suggests that the resulting increase in working from home will outlast these policies themselves, policy makers want to know what the expected effects of working from home on travel behaviour will be in a post-pandemic world. To answer this question it is important to understand the relations between working from home and travel behaviour. To improve the understanding of the relations between working from home and travel behaviour we apply longitudinal modelling techniques using panel data from the Netherlands Mobility Panel. This allows us to separate between-persons and within-persons relations and effects. We find a negative effect of working from home on commute travel time both before and during the pandemic and a positive effect on leisure travel time only during the pandemic. The sizes of these effects remained roughly similar during the pandemic, although the extent to which working from home affects commute travel time increased during the pandemic. The net effect of working from home on travel time as a whole is negative, indicating that working from home policies could be used to reduce travel time. The results show that part of the relationships between working from home and travel behaviour has changed during the pandemic. As a result, policy makers and transport operators should be careful when estimating future travel demand based on extrapolations of relationships found only before or during the pandemic.
Visualization system of Hlai ethnic village landscape design based on machine learning
Authors: Liu Jun , Wu Xiaoli , Zhang Yi , Wang Li 
Published: October 2023

Abstract
Ethnic villages are an important part of villages, and also the inheritance of ethnic, cultural and spiritual forms. In a certain sense, the overall landscape characteristics of ethnic villages are the epitome of a national culture and image. In this paper, a landscape visualization scheme based on machine learning is proposed by combining the computing form of machine learning with the current visualization system. And use the principle of logistic regression and the principle of support vector calculation to analyze, select the appropriate data set for trend data analysis. Finally, taking the Hlai ethnic village landscape as the research direction in Hainan, the research is carried out in the fields of landscape science and ecology, and the comprehensive analysis is carried out in combination with the national culture, social, ecological and aesthetic sensibility, and the Hlai ethnic village's own landscape index system is established. The research shows that the visual system research on the Hlai ethnic village landscape can reflect the Hlai ethnic village cultural landscape to a certain extent, and is helpful to the protection and innovation of the Hlai ethnic villages; It is helpful to establish the landscape classification of Hlai ethnic villages and the establishment of future goals; To create their own national cultural landscape for Hlai ethnic villages; At the same time, it helps the sustainable development of Hlai ethnic villages and provides practical methods for the construction of Hlai ethnic villages.
Artificial Intelligence Inspired Design of Non-Isothermal Aging for γ - γ' Two- phase, Ni-Al Alloys
Authors: Nandal Vickey , Dieb Sae , Bulgarevich Dmitry S. , Osada Toshio , Koyama Toshiyuki , Minamoto Satoshi , Demura Masahiko 
Published: October 2023

Abstract
In this paper, a state-of-the-art Artificial Intelligence (AI) technique is used for a precipitation hardening of Ni-based alloy to predict more flexible non-isothermal aging (NIA) and to examine the possible routes for the enhancement in strength that may be practically achieved. Additionally, AI is used to integrate with Materials Integration by Network Technology, which is a computational workflow utilized to model the microstructure evolution and evaluate the 0.2% proof stress for isothermal aging and NIA. As a result, it is possible to find enhanced 0.2% proof stress for NIA for a fixed time of 10 minutes compared to the isothermal aging benchmark. The entire search space for aging scheduling was ~ 3 billion. Out of 1620 NIA schedules, we succeeded in designing the 110 NIA schedules that outperformed the isothermal aging benchmark. Interestingly, it is found that early-stage high-temperature aging for a shorter time increases the γ' precipitate size up to the critical size and later aging at lower temperature increases the γ' fraction with no anomalous change in γ' size. Therefore, employing this essence from AI, we designed an optimum aging route in which we attained an outperformed 0.2% proof stress to AI-designed NIA routes.
Effectiveness of a nurse-led management intervention on systolic blood pressure among type 2 diabetes patients in Uganda: a cluster randomized trial
Authors: LUMU WILLIAM , Bahendeka Silver , Kibirige Davis , Wesonga Ronald , Mutebi Ronald Kasoma 
Published: October 2023

Abstract

Background
Hypertension (HT) is an orchestrator of atherosclerotic cardiovascular disease (ASCVD) in persons living with type 2 Diabetes (T2D). Control of systolic blood pressure (SBP) and HT as a whole is suboptimal in diabetes partly due to scarcity of doctors. While nurse-led interventions are pragmatic and cost-effective in the control of HT in primary health care, their effectiveness on SBP control among patients with T2D in Uganda is scantly known.
Aim
We evaluated the effectiveness of a nurse-led management intervention on SBP among T2D patients with a high ASCVD risk in Uganda.
Methods
A two-armed cluster randomized controlled trial was conducted to compare the nurse-led management intervention with usual doctor-led care. The intervention involved training of nurses to provide structured health education, protocol based HT/CVD management, 24-hour phone calls and 2 monthly text messages for 6 months. The primary outcome was mean change in SBP between baseline and after 6 months. The secondary outcome was change in proportion of patients reaching treatment targets for SBP, total cholesterol (TC), fasting blood sugar (FBS), glycated hemoglobin (HbA1C), low density lipoprotein cholesterol (LDL), triglycerides (TG) and body mass index (BMI). The study was analyzed with intention to treat principle. Generalized estimating equations were used to assess for intra-cluster effect modifiers. Statistical significance was set at 0.05 for all analyses.
Results
Eight clinics (n = 388 patients) were included (intervention 4 clinics; n = 192, control 4 clinics; n = 196).A nurse-led intervention reduced SBP by 11.21 ± 16.02mmhg with a mean difference between the groups of -13.75mmHg (95% CI-16.48 to 11.02, P < 0.001).Diastolic blood pressure was reduced by 6.77 ± 9.48mmHg with a mean difference between groups of -7.17mmHg (95%C1 -8.87 to -5.48, p < 0.001). An increase in SBP of 2.53 ± 10.95mmhg was noted in the control group. The proportions of patients reaching target for SBP(95%CI -0.234 to 0.077,p < 0.001),diastolic blood pressure(95% CI-0.359 to 0.137,p < 0.001),LDL(95% -0.075 to 0.007,p < 0.001)and TGs(95% -0.0155 to 0.032,p = 0.002) increased while those of FBS (P = 0.66), HbA1c (P = 0.710) and BMI (P = 0.414) did not change.
Conclusion
A nurse-led management intervention reduces SBP and ASCVD risk among patients with T2D.Such an intervention may be pragmatic in screening and management of HT/ASCVD in Uganda.
Trial Registration: Pan African Clinical Trial Registry, PACTR202001916873358, registered 6th October 2019.
Microalgae as a novel biofactory for biocompatible and bioactive extracellular vesicles
Authors: Bongiovanni Antonella , Adamo Giorgia , Santonicola Pamela , Picciotto Sabrina , Gargano Paola , Nicosia Aldo , Longo Valeria , Aloi Noemi , Romancino Daniele , Paterna Angela , Rao Estella , Raccosta Samuele , Noto Rosina , Salamone Monica , Costa Salvatore , Sano Caterina Di , Zampi Giuseppina , colombo Paolo , Wei Mingxing , Touzet Nicolas , Manno Mauro , Schiavi Elia Di 
Published: October 2023

Abstract

Nanoalgosomes are extracellular vesicles (EVs) released by microalgal cells that can mediate intercellular and cross-kingdom communication. In the present study, the optimization of high quality nanoalgosome manufacturing from cultures of the marine microalgae Tetraselmis chuii has been enhanced by quality control procedures, applying robust biophysical and biochemical characterizations. Then, we evaluated the biological properties of nanoalgosomes in pre-clinical models. Our investigation of nanoalgosome biocompatibility included toxicological analyses, starting from studies on the invertebrate model organism Caenorhabditis elegans and proceeding to hematological and immunological evaluations in mice and human cells. Nanoalgosome biodistribution was evaluated in mice with accurate space-time resolution, and in C. elegans at cellular and subcellular levels. Further examination highlighted the antioxidant and anti-inflammatory bioactivities of nanoalgosomes. This holistic approach to nanoalgosome characterization showcases that nanoalgosomes are innate effectors for novel cosmetic formulations and EV-based therapies.
Wing Interferential Patterns (WIPs) and machine learning for the classification of some Aedes species of medical interest
Authors: CANNET Arnaud , SIMON-CHANE Camille , HISTACE Aymeric , AKHOUNDI Mohammad , ROMAIN Olivier , SOUCHAUD Marc , JACOB Pierre , SERENO Darian , GOUAGNA Louis-Clément , Mathieu-Daude Françoise , Sereno Denis , Bousses Phillipe 
Published: October 2023

Abstract
Hematophagous insects belonging to the Aedes genus are proven vectors of viral and filarial pathogens of medical interest. Aedes albopictus is an increasingly important vector because of its rapid worldwide expansion. In the context of global climate change and the emergence of zoonotic infectious diseases, identification tools with field application are required to strengthen efforts in the entomological survey of arthropods with medical interest. Large scales and proactive entomological surveys of Aedes mosquitoes need skilled technicians and/or costly technical equipment, further puzzled by the vast amount of named species. In this study, we developed an automatic classification system of Aedes species by taking advantage of the species-specific fingerprinting displayed by Wing Interferential Patterns. A database containing 494 photomicrographs of 24 Aedes spp. from which those documented with more than ten pictures have undergone a deep learning methodology to train a convolutional neural network and test its accuracy to classify samples at the genus, subgenus, and species taxonomic levels. We recorded an accuracy of 95% at the genus level and >85% for two (Ochlerotatus and Stegomyia) out of three subgenera tested. Lastly, eight were accurately classified among the 10 Aedes sp. that have undergone a training process with an overall accuracy of>70%. Altogether these results demonstrate the potential of this methodology for Aedes species identification and will represent a tool for the future implementation of large-scale entomological surveys.
Exfoliated g-C3N4 nanoribbon functionalized green MgO NPs for dye degradation and in-vitro biological analysis
Authors: Jaganathan Madhuganesan , Surendhiran Srinivasan , Savitha Saravanan , Karthik Arumugam , Karthick Mahendhiran , Vidaarth Tamilselvi Mohanasundaram Naren , Balu Kolathupalayam Shanmugam , Jagan Krishnaveni Selva Ganeshan , Kalpana Balakrishnan 
Published: October 2023

Abstract
This article reports a green process for synthesizing MgO nanoparticles supported by the exfoliated g-C3N4 nanocomposite. Various techniques characterize were employed for the prepared MgO, g-C3N4 and MgO/g-C3N4 nanocomposites. The cubic and hexagonal phase structure was achieved for synthesized MgO NPs and g-C3N4, respectively, with spherical and curled ribbon-like morphology. The specific surface area was obtained as 70.48, 54.22 and 79.11 m2/g, respectively, for MgO, g-C3N4 and MgO/g-C3N4 nanocomposite. Similarly, corresponding optical properties were achieved with an energy gap of 3.42, 2.48, and 2.78 eV. XPS analysis confirms the purity of MgO/g-C3N4 nanocomposite by detecting their characteristic elemental peaks. The bioactivities of MgO, g-C3N4 and MgO/g-C3N4 nanocomposite, including antibacterial, turbidimetric and antioxidant efficacy, were investigated. The antibacterial activity was Gram-positive bacterial strains are more susceptible to treatment than Gram-negative ones due to the increased production of ROS in the MgO/g-C3N4 nanocomposite. Further, MgO, g-C3N4 and MgO/g-C3N4 nanocomposite were employed as catalysts for the degradation of cationic substances (Crystal Violet) and anionic (Eosin Yellow) dye under sunlight irradiation. Their photocatalytic activity towards CV and EY degradation of dyes was highly influenced, and efficiency of 98.9% and 97.33% for MgO/g-C3N4 nanocomposite. Therefore, the increased surface area with the active site and UV-Visible region of MgO/g-C3N4 is more suitable for dye effluent treatment.