bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lessons in clinical reasoning – pitfalls, myths, and pearls: shoulder pain as the first and only manifestation of lung cancer
Authors: Díaz-Abad Julia , Aranaz-Murillo Amalia , Mayayo-Sinues Esteban , Canchumanya-Huatuco Nila , Schaye Verity 
Published: February 2024

Abstract

Objectives
Lung cancer is the leading cause of cancer-related death and poses significant challenges in diagnosis and management. Although muscle metastases are exceedingly rare and typically not the initial clinical manifestation of neoplastic processes, their recognition is crucial for optimal patient care.

Case presentation
We present a case report in which we identify the unique scenario of a 60-year-old man with shoulder pain and a deltoid muscle mass, initially suggestive of an undifferentiated pleomorphic sarcoma. However, further investigations, including radiological findings and muscle biopsy, revealed an unexpected primary lung adenocarcinoma. We performed a systematic literature search to identify the incidence of SMM and reflect on how to improve and build on better diagnosis for entities as atypical as this. This atypical presentation highlights the importance of recognizing and addressing cognitive biases in clinical decision-making, as acknowledging the possibility of uncommon presentations is vital. By embracing a comprehensive approach that combines imaging studies with histopathological confirmation, healthcare providers can ensure accurate prognoses and appropriate management strategies, ultimately improving patient outcomes.

Conclusions
This case serves as a reminder of the need to remain vigilant, open-minded, and aware of cognitive biases when confronted with uncommon clinical presentations, emphasizing the significance of early recognition and prompt evaluation in achieving optimal patient care.
Against the strain – a diachronic perspective on prehistoric European and Near Eastern protective/symbolic archery equipment
Authors: Zimmermann Thomas 
Published: February 2024

Abstract
This contribution reviews selected bone and stone plaques with double or multiple opposite perforations from Pre-Pottery Neolithic Near Eastern contexts in the light of them having possibly served as symbolic or protective archery equipment. The presence of perforated plaques from Later Neolithic Europe is a well-attested phenomenon in funeral contexts and is commonly labelled as bracers or wrist-guards. With their actual practical purpose of efficiently preventing the forearm from the slashing of a bowstring being probably of subordinate importance, there seems to be a consensus that they were, if not protective, then symbolic adornments in connection with hunting as being not only a profane, food-acquiring routine but simultaneously a ritually loaded, status-enhancing endeavor. The same is assumed for specific “plaques” from much earlier post-Pleistocene contexts in Upper Mesopotamia, which might have served an identical purpose in the frame of cultural synchronisms.
Additions to orchid flora of Bhutan III: <i>Paphiopedilum × pradhanii</i>
Authors: Dorji Phub , Gyeltshen Phub , Tobgay Kezang , Dorji Sherab , Dorji Ugyen , Doya Sha Kinley , Kumar Pankaj 
Published: February 2024

Paphiopedilum × pradhanii, a natural hybrid between P. fairrieanum (subgenus Paphiopedilum, section Ceratopetalum) and P. venustum (subgenus Paphiopedilum, section Barbata), is reported for the first time from Bhutan. Detailed geographical distribution, ecology, and conservation status, and dichotomous keys to all Paphiopedilum species found in Bhutan are provided. A brief description of the parents of this hybrid is also provided.
Notes on australasian orchids 8: Eight new species of <i>Hymenochilus</i> (Cranichideae: Pterostylidinae) and clarification of two previously described species
Authors: Jones David L. , Zimmer Heidi C. , Clements Mark A. 
Published: February 2024

Eight new species of Hymenochilus from Australia are described and illustrated. Six of the new species have affinities to (and are here compared with) H. cycnocephalus: H. anemophilus, H. calcicola, H. cymbellus, H. longipes, H. nemoralis and H. pachylus. Hymenochilus anemophilus is shorter (2–8 cm), with dark green strongly veined rosette leaves, crowded dark green flowers, oblong to obovate labellum lamina and, a broader blunter beak on the labellum appendage; H. calcicola is shorter (3–12 cm), crowded green flowers with prominent dark green stripes, ovate petals with a strongly developed basal flange on the anterior side and narrow elliptic labellum lamina with a broad pointed beak on the labellum appendage; H. cymbellus differs by its sparser basal rosette with narrower rosette leaves, thinner scapes, flowers with distinct darker green stripes and shallowly saccate lateral sepals that narrow inwards to a distinctly pointed apex; H. longipes differs by its thin-textured rosette leaves, widely spaced darker green flowers with darker green veins, elliptic-obovate labellum lamina and a longer labellum basal appendage which protrudes prominently from the flower in side view; H. nemoralis has longer rosette leaves, thicker scape and darker green flowers with prominent narrow dark green stripes; H. pachylus has thicker rosette leaves, taller, thicker scape, flowers prominently striped, elliptic-obovate labellum lamina and labellum appendage with a short thick beak. Two of the new species have affinities (and are here compared) with H. muticus: H. pagophilus and H. pisinnus. Hymenochilus pagophilus differs by its moderately crowded to crowded flowers, broader, shinier flowers and rectangular-obovate labellum and H. pisinnus differs by its smaller rosette with smaller, narrower leaves, thinner scape, smaller flowers, that are often on long pedicels, shorter, shallowly saccate lateral sepals, smaller rhomboid petals and, smaller obovate labellum. In addition, Hymenochilus cycnocephalus and H. muticus, are characterised in the strict sense with full descriptions, distribution, and habitat.
PEMIKIRAN SYEKH ABDUSSOMAD AL-PALIMBANI DALAM KITAB FAIDHAL IHSANI (TINJAUAN TERHADAP TUJUAN DAKWAH)
Authors: Choiriyah Choiriyah 
Published: February 2024

Abdussomad al-Palimbani lahir di Palembang tahun 1150 H / 1736 M. Pemikiran-pemikiran dari tokoh tasawuf Sunni ini sebagaimana yang ditulis salah seorang muridnya di dalam kitab Faidhal Ihsan, jika ditinjau dalam persfektif dakwah bertujuan mengajak mad’u atau objek dakwah memiliki akhlak yang terpuji, meliputi akhlak kepada Allah dan akhlak kepada guru. Selain itu Ulamak Nusantara yang banyak mengahasilkan karya tulis ini juga mengajak mad’u untuk mempelajari tasawuf dan memasuki tarekat Samaniyah.
Bimbingan Rohani Islam dalam Meningkatkan Ibadah Shalat Pada Pasien Rawat Inap
Authors: Komaruddin Komaruddin 
Published: February 2024

ABSTRACT:
This researcher aims to describe the awareness of worship in inpatients and the role of Islamic spiritual guidance in increasing awareness of carrying out worship (Salat) in inpatients. This research is motivated by the low understanding and awareness of the community to continue to carry out worship even though they are sick and being treated in a hospital. The approach used in this research is a qualitative approach with a type of field research. The subjects of this study were three inpatients in the internal medicine ward. Data collection techniques, namely the method of observation, interviews, and documentation. While the data analysis techniques used are data reduction, data presentation and drawing conclusions. The results of this study indicate that prior to carrying out the guidance of the three subjects they did not have an understanding of the procedures for praying when they were sick, they did not have awareness of the importance of praying even though they were sick. Islamic spiritual guidance is carried out through three stages, namely the preliminary stage (establishing closeness with patients and identifying problems), the core stage (guidance on procedures for worship/praying when sick, motivation to increase awareness of praying when sick). Islamic spiritual guidance has an important role in raising awareness of worship in inpatients, this is evidenced by changes in knowledge of procedures for purification and prayer when they are sick, the emergence of a desire to pray and a commitment to continue praying even though they are sick.

KEYWORDS: Islamic Spiritual Guidance, Worship Awareness, patient
FESTIVAL CIKAR SEBAGAI BUDAYA LOKAL MASYARAKAT KECAMATAN AMBULU KABUPATEN JEMBER TAHUN 1989-2018
Authors: Maulana Moh Ishaq 
Published: February 2024

This article discusses the Cikar Festival as a Local Culture of the People of Ambulu District, Jember Regency, 1989-2018. The purpose of this paper is to find out the history of the beginning of the Cikar Festival in Ambulu Subdistrict, what efforts have been made by the community and the government to preserve the Cikar Festival, and to know the development of the Cikar Festival in 1989-2018. This research uses historical methods to uncover the problems that are being studied. This festival originated from the habits of the owners of the cikar in Ambulu Subdistrict, who traveled to Watu Ulo Beach, which is held at every Lebaran Ketupat celebration. In 1989 these activities began to be contested by several Ambulu people. This is evidenced by establishing the Margo Rukun Association, as a forum for cikar artisans to preserve these activities to be more coordinated. Cikar itself is a traditional transportation tool in the form of a cart pulled by two adult cows, which some people in Ambulu District still use. The dynamics related to the reduction in the number of cikar participants are due to the decreasing number of cikar owners and the progress of an increasingly modern era. The significant reduction in the number of participants in the Cikar festival in 2018 made the government not remain silent. So that year the Regent of Jember and the Department of Tourism and Culture of Jember Regency (Disparbud) who were present at the festival made an effort to keep the cikar at Ambulu holding this festival every year and strive for the Cikar festival to become one of the cultural icons in Jember.
Keywords: Transportation; Tradition; Festival
Consumption of Limosilactobacillus fermentum Inhibits Corneal Damage and Inflammation in Dry Eye Disease Mice Model through Regulating the Gut Microbiome
Authors: Lee Kippeum , Gwon Hyeonjun , Shim Jae Jung , Kim Joo Yun , Lee Jae Hwan 
Published: February 2024

(1) The present study investigated the effect of orally administered Limosilactobacillus fermentum HY7302 (HY7302) on the relationship between ocular tissue and the microbiome in the corneal injured dry eye mice model. (2) 0.1% benzalkonium chloride (BAC) was applied to the ocular surface for 14 days to induce corneal injury in male Balb/c mice. During the BAC treatment period, HY7302 (1 × 108 CFU/kg/day or 1 × 109 CFU/kg/day) or omega-3 positive control (200 mg/kg/day) were administered orally (n = 8/group). To examine signaling pathways affected by HY7302 treatment, the in vitro effects of HY7302 on tight junctions and the inflammatory response were investigated in a mouse colon epithelial cell line, CMT-93. (3) BAC exposure decreased tear production, induced ocular inflammation and corneal epithelial detachment, and altered gut microbiota. However, oral administration of HY7302 restored tear secretion and decreased corneal epithelial detachment in BAC-treated corneal injury mice. Further, HY7302 alleviated corneal inflammation via modulation of matrix metalloproteinase-9 (MMP-9) expression and alterations in gut microbiota composition. (4) These findings suggest that the gut–eye axis interaction between gut microbiota and eye tissue affects disease severity in corneal injury, and that alteration of the microbiota by HY7302 could improve eye health by regulating the inflammatory response.
County-Level Factors Associated With Influenza and COVID-19 Vaccination in Indiana, 2020‒2022
Authors: Kasting Monica L. , Laily Alfu , Burney Heather N. , Head Katharine J. , Daggy Joanne K. , Zimet Gregory D. , Schwab-Reese Laura M. 
Published: February 2024

Objectives. To assess COVID-19 and influenza vaccination rates across Indiana’s 92 counties and identify county-level factors associated with vaccination. Methods. We analyzed county-level data on adult COVID-19 vaccination from the Indiana vaccine registry and 2021 adult influenza vaccination from the Centers for Disease Control and Prevention. We used multiple linear regression (MLR) to determine county-level predictors of vaccinations. Results. COVID-19 vaccination ranged from 31.2% to 87.6% (mean = 58.0%); influenza vaccination ranged from 33.7% to 53.1% (mean = 42.9%). In MLR, COVID-19 vaccination was significantly associated with primary care providers per capita (b = 0.04; 95% confidence interval [CI] = 0.02, 0.05), median household income (b = 0.23; 95% CI = 0.12, 0.34), percentage Medicare enrollees with a mammogram (b = 0.29; 95% CI = 0.08, 0.51), percentage uninsured (b = −1.22; 95% CI = −1.57, −0.87), percentage African American (b = 0.31; 95% CI = 0.19, 0.42), percentage female (b = −0.97; 95% CI = −1.79, ‒0.15), and percentage who smoke (b = −0.75; 95% CI = −1.26, −0.23). Influenza vaccination was significantly associated with percentage uninsured (b = 0.71; 95% CI = 0.22, 1.21), percentage African American (b = −0.07; 95% CI = −0.13, −0.01), percentage Hispanic (b = −0.28; 95% CI = −0.40, −0.17), percentage who smoke (b = −0.85; 95% CI = −1.06, −0.64), and percentage who completed high school (b = 0.54; 95% CI = 0.21, 0.87). The MLR models explained 86.7% (COVID-19) and 70.2% (influenza) of the variance. Conclusions. Factors associated with COVID-19 and influenza vaccinations varied. Variables reflecting access to care (e.g., insurance) and higher risk of severe disease (e.g., smoking) are notable. Programs to improve access and target high-risk populations may improve vaccination rates. ( Am J Public Health. 2024;114(4):415–423. https://doi.org/10.2105/AJPH.2023.307553 )
Addressing the Impact of Race and Ethnicity on Musculoskeletal Spine Care in the United States
Authors: Adjei Joshua , Tang Melissa , Lipa Shaina , Oyekan Anthony , Woods Barrett , Mesfin Addisu , Hogan MaCalus V. 
Published: February 2024

➤ Despite being a social construct, race has an impact on outcomes in musculoskeletal spine care.➤ Race is associated with other social determinants of health that may predispose patients to worse outcomes.➤ The musculoskeletal spine literature is limited in its understanding of the causes of race-related outcome trends.➤ Efforts to mitigate race-related disparities in spine care require individual, institutional, and national initiatives.
The Nonlinear Influence of Digital Finance on Green Economic Efficiency: Evidence from China
Authors: Liang Guibao , Xia Qiao , Zhang Lijie 
Published: February 2024

Abstract
Digital finance (DF) has an essential impact on improving green economy efficiency (GEE) by demonstrating environmental friendliness in promoting technological innovation and the flow of factors. Based on the panel data of 30 provinces in China from 2011 to 2020, this paper uses the super-efficiency SBM model with undesirable outputs to measure the provincial GEE. It tests the nonlinear impact of DG on green economic efficiency. Additionally, a heterogeneity analysis has been conducted. The conclusions are: (1) a significant, positive U-shaped nonlinear relationship exists between DF and GEE. The robustness test and the instrumental variable model verify that the results are still valid; (2) the results of the heterogeneity analysis illustrate that the U-shaped relationship between DF and GEE is significant in undeveloped regions. In contrast, it shows a linear promoting effect in the developed areas; (3) mechanism research demonstrates that the regional technological innovation level is an effective mechanism of the U-shaped relationship; (4) the moderating effect test establishes that environmental regulation can positively moderate the nonlinear relationship between DF and GEE. Therefore, the government can give free rein to the functions of DF to improve the efficiency of the green economy.
Gravitational Interactions of Two Small Evaporating Drops
Authors: Rother Michael 
Published: February 2024

Abstract

Relative trajectories are determined for a pair of water drops falling in air with radii between 2 μm and 30 μm. The droplets are small enough that diffusion dominates convection in evaporation, but significant drop inertia at low Reynolds number is considered. In addition to hydrodynamic and lubrication forces, attractive van der Waals forces and Maxwell slip are taken into account. Because the loss of mass is not uniform due to the presence of a second drop, and mass transfer and momentum transfer are effectively decoupled, the droplet position needs to be assessed. Three outcomes are compared. The isolated drop result for both droplets is employed as a base case, since the mass loss is constant over each drop surface. Alternatively, the bispherical coordinate solution for two evaporating drops is applied, with the drop positions 1) fixed by the hydrodynamics or 2) allowed to move based on the nonspherical mass loss. In all three cases, evaporation leads to weaker inertial effects and stronger hydrodynamic effects. The single sphere model has the largest drop gap, followed by the bispherical coordinate solutions with a fixed and movable center, respectively. Critical horizontal offsets for coalescence are also calculated with a finite vertical offset. With both attractive molecular forces and slip, all three approaches to evaporation lead to similar results, making the choice of method nearly inconsequential. Moderate agreement between previous experiments and an approximate, generalized form of the current theory is obtained for the evaporation rate of falling drops.
MiR-502-3p/miR-501-3p as potential synaptic biomarker in Alzheimer’s Disease: Analysis based on cerebrospinal fluid and neuropathology
Authors: Devara Davin , Sharma Bhupender , Torres Melissa M. , Rodriguez Sheryl , Rodarte Daniela , Kumar Subodh 
Published: February 2024

Abstract
MiRNAs are currently being studied for their biomarker potential in many diseases, including Alzheimer’s disease (AD). Here, we explored the biomarker potential of miR-502-3p/miR-501-3p in cerebrospinal fluid (CSF) exosomes in accordance with amyloid plaques and neurofibrillary tangles (NFTs) severity in AD brain. The miR-502-3p/miR-501-3p expression were analyzed in CSF exosomes isolated from AD and unaffected controls (UC) samples. The miR-502-3p/miR-501-3p levels were examined with CSF Aβ1–40, Aβ1–42, Tau, p-Tau levels and with neuropathology of AD brain. The miR-502-3p/miR-501-3p expression levels were upregulated in AD CSF exosomes relative to UC CSF exosomes. MiR-502-3p level was positively correlated with CSF Aβ1–40 level while miR-501-3p was positively correlated with CSF p-Tau levels. Expressions of miR-502-3p/miR-501-3p were significantly associated with severity of amyloid plaques and NFTs in the entorhinal cortex, hippocampus, amygdala, middle frontal gyrus, inferior parietal lobule, and superior temporal gyrus. Therefore, miR-502-3p/miR-501-3p panels could potentially be useful biomarkers for AD in future.
Design and Development of a Novel Multirotor Configuration with Counter-Rotating Coaxial Propellers
Authors: Khah Mohammad Malakouti , Esmailifar Sayyed Majid , Saadat Sepehr 
Published: February 2024

Abstract
In this study, a novel multirotor configuration has been developed, which utilizes a coaxial counter-rotating propeller with a large diameter at the center and four propellers with smaller diameters on four arms in an X configuration. The research pursues two main objectives. The first objective is to establish a development method for multirotors based on the well-known V-diagram approach in system development. The proposed method enables the design team to analyse and evaluate the multirotor at each stage of the design process, from the system to the component level, and improve the design with greater speed and accuracy. Additionally, the proposed approach can be integrated with various optimization methods, if necessary, to achieve an optimal design. The second objective is to provide the proof-of-concept of the novel multirotor configuration. This objective is pursued across different evaluation sections, from evaluating individual components to fully evaluating the multirotor, to assess the performance of this novel configuration and identify its advantages and disadvantages. The results of various evaluations demonstrate the proposed development process's practicality and proves that the novel configuration is operational and competitive with conventional multirotors in various applications.
Associations between Hypothyroidism in Pregnancy and Adverse Maternal and Neonatal Outcomes: A cohort study
Authors: Kindi Rahma Al , Ghamari Noof Al , Malki Amina Al , Ismaili Aida Al , Sumri Hana Al 
Published: February 2024

Abstract
Objective
This study aimed to determine associations between hypothyroidism during pregnancy and selected maternal and neonatal outcomes.
Methods
A retrospective, cohort study was conducted between January 2018 and December 2020 at the two main tertiary hospitals in Muscat, Oman. A total of 408 Omani pregnant women aged 18–45 years were included. Data from electronic medical records were compared between women with overt or subclinical hypothyroidism (n = 201; the exposed group) and those with normal thyroid function (n = 207; the matched unexposed group) to determine associations with selected outcomes.
Results
In terms of maternal outcomes, no significant differences were observed between exposed and unexposed groups with regards to the risk of gestational diabetes mellitus, pregnancy-induced hypertension, or pre-eclampsia (P > 0.05). However, pregnant women with hypothyroidism were twice as likely to exhibit iron deficiency anemia at delivery compared to women with normal thyroid function (relative risk [RR]: 2.22, 95% confidence interval [CI]: 1.68–2.94; P < 0.001). Regarding neonatal outcomes, newborns born to mothers with hypothyroidism were less likely to be premature (RR: 0.83, 95% CI: 0.23–3.06), have low birth weight (RR: 0.86, 95% CI: 0.46–1.55), and exhibit macrosomia (RR: 0.52, 95% CI: 0.096–2.81) or abnormal cord TSH levels (RR: 0.21, 95% CI: 0.01–4.31); however, these associations were not statistically significant (P > 0.05).
Conclusion
Pregnant women with hypothyroidism were not found to be at increased risk of adverse maternal and neonatal outcomes compared to those without hypothyroidism. These findings could be attributed to the fact that most of the studied pregnant women with hypothyroidism were already receiving thyroxine replacement therapy, thereby achieving euthyroid status from a clinical and biochemical standpoint.
Analysis of ionospheric anomalies before earthquakes with Mw6.5 and above in Japan during 2011-2022
Authors: Li Zhen , Tao Zhen , Cao Lianhai 
Published: February 2024

Abstract
In order to study the seismic-ionospheric coupling relationship, this paper selects window values based on wavelet power spectrum method, and obtains the 27-day periodicity of wavelet power spectrum in the full time domain that passes 95% significance test. Then, sliding quartile method is used to analyze the earthquakes above Mw6.5 in Japan from 2011 to 2022, which exclude hybrid effects. Sunspot number (SSN), 10.7cm radio flux (F10.7), solar wind velocity (Vsw), storm ring current index (DST), and global Geomagnetic activity index (KP) are excluded as interference terms to eliminate the influence of solar and geomagnetic activity. According to the lithosphere-atmosphere-ionospheric coupling mechanism (LAIC) and global TECmap, the abnormal changes on the 29th day before the earthquake (February 15, 2022), which do not conform to the previous research rules, are analyzed to prove that TEC anomalies caused by earthquakes. The statistical analysis of ionospheric TEC anomalies shows that the magnitude of earthquake is positively correlated with the amplitude of TEC anomalies, and the occurrence time of ionospheric anomalies tends to lag as the magnitude increases.