bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared and distinct biological mechanisms for anxiety and sensory over‐responsivity in youth with autism versus anxiety disorders
Authors: Cummings Kaitlin K. , Jung Jiwon , Zbozinek Tomislav D. , Wilhelm Frank H. , Dapretto Mirella , Craske Michelle G. , Bookheimer Susan Y. , Green Shulamite A. 
Published: October 2023

AbstractSensory over‐responsivity (SOR) is a prevalent cross‐diagnostic condition that is often associated with anxiety. The biological mechanisms underlying the co‐occurrence of SOR and anxiety symptoms are not well understood, despite having important implications for targeted intervention. We therefore investigated the unique associations of SOR and anxiety symptoms with physiological and neural responses to sensory stimulation for youth with anxiety disorders (ANX), autism spectrum disorder (ASD), or typical development (TD). Age/IQ‐matched youth aged 8–18 years (22 ANX; 30 ASD; 22 TD) experienced mildly aversive tactile and auditory stimuli during functional magnetic resonance imaging and then during skin conductance response (SCR) and heart rate (HR) measurements. Caregivers reported on participants' SOR and anxiety symptoms. ASD/ANX youth had elevated SOR and anxiety symptoms compared to TD. ASD/ANX youth showed similar, heightened brain responses to sensory stimulation compared to TD youth, but brain responses were more highly related to SOR symptoms in ASD youth and to anxiety symptoms in ANX youth. Across ASD/ANX youth, anxiety symptoms uniquely related to greater SCR whereas SOR uniquely related to greater HR responses to sensory stimulation. Behavioral and neurobiological over‐responsivity to sensory stimulation was shared across diagnostic groups. However, findings support SOR and anxiety as distinct symptoms with unique biological mechanisms, and with different relationships to neural over‐reactivity dependent on diagnostic group. Results indicate a need for targeted treatment approaches.
White‐rot fungus Phlebia floridensis ITM 12: Laccase production, oxidoreductase profile, and hydrogen‐peroxide independent activity
Authors: Magaña‐Ortiz Denis , López‐Castillo Laura M. , Amezquita‐Novelo Roberto 
Published: October 2023

AbstractPhlebia genus is a relevant group of fungi with a crucial role in numerous ecosystems. In tropical and subtropical areas this genus allows the efficient degradation of lignin and carbon recovery; however, the majority of these fungal species remain undiscovered. The main purpose of this work was to determine the enzymatic activity of extracellular proteins of a novel Phlebia floridensis strain isolated in Yucatan Peninsula, Mexico. The results that are reported here demonstrate that the soluble protein extract of P. floridensis can degrade a broad spectrum of recalcitrant compounds. This induced protein extract is able to modify not only phenolic and nonphenolic compounds, but also anthroquinone dyes, even without the addition of exogenous hydrogen peroxide. Using liquid chromatography–mass spectrometry (LC‐MS), we were able to identify a novel chloroperoxidase in enzymatic extract. As far as we know, this is the first report about the presence of this type of enzyme in the Phlebia genus.
Therapeutic Ultrasound for Enhanced Corneal Permeability to Macromolecules
Authors: Allison Claire , Jiménez Annette , Ramajayam Krishna , Haemmerich Dieter , Zderic Vesna 
Published: October 2023

ObjectivesTopically applied macromolecules have the potential to provide vision‐saving treatments for many of the leading causes of blindness in the United States. The aim of this study was to determine if ultrasound can be applied to increase transcorneal drug delivery of macromolecules without dangerously overheating surrounding ocular tissues.MethodsDissected corneas of adult rabbits were placed in a diffusion cell between a donor compartment filled with a solution of macromolecules (40, 70 kDa, or 150 kDa) and a receiver compartment. Each cornea was exposed to the drug solution for 60 minutes, with the experimental group receiving 5 minutes of continuous ultrasound or 10 minutes of pulsed ultrasound at a 50% duty cycle (pulse repetition frequency of 500 ms on, 500 ms off) at the beginning of treatment. Unfocused circular ultrasound transducers were operated at 0.5 to 1 W/cm2 intensity and at 600 kHz frequency.ResultsThe greatest increase in transcorneal drug delivery seen was 1.2 times (P < .05) with the application of pulsed ultrasound at 0.5 W/cm2 and 600 kHz for 10 minutes with 40 kDa macromolecules. Histological analysis revealed structural damage mostly in the corneal epithelium, with most damage occurring at the epithelial surface.ConclusionsThis study suggests that ultrasound may be used for enhancing transcorneal delivery of macromolecules of lower molecular weights. Further research is needed on the long‐term effects of ultrasound parameters used in this study on human ocular tissues.
Kinetics of direct and water‐mediated tautomerization reactions of nucleobases at low temperatures ⩽200 K
Authors: Würmel Judith , Simmie John M. 
Published: October 2023

AbstractDetailed chemical kinetic mechanisms for the synthesis of complex organic molecules in the interstellar medium are at an early stage of developement. That such synthesis must take place is well‐known from chemical analysis of sampled asteroids. As molecular complexity increases the number of possible structural isomers also increases with the consequence that the nascent species may adopt a different spatial arrangement, to the lowest energy one. As part of a program of investigations of the hydrogen atom transfer reaction or tautomerization of imidic acid–amide species H‐O=C‐N‐ O=C‐N‐H we have studied the kinetics for a number of nucleobases, namely cytosine, thymine and uracil where a cyclic form of tautomerism (lactim–lactam) is encountered. Together with a fourth, 5‐aza‐uracil (1,3,5‐triazine‐2,4(1H,3H)‐dione), we report on the rates of reaction at low temperatures 50–200 K for both the direct unimolecular process and the similar transformation mediated by an additional water molecule. We show that these tautomerization reactions can be categorized into three classes, and highlight the importance of quantum mechanical tunneling on the rate constants at these low temperatures. We further present some thermochemistry data, such as formation enthalpies, entropies, isobaric heat capacities and enthalpy functions.
Promoting gender diversity in the editorial boards of major otorhinolaryngology journals: A call for inclusion and equal representation
Authors: Ünal Asude , Çeçen Ayşe 
Published: October 2023

AbstractObjectivesThe aim of our study was to investigate the representation of women in the editorial boards of otorhinolaryngology journals indexed in the Science Citation Index‐Expanded (SCIE) database.MethodsWe examined the gender distribution of editors‐in‐chief, editorial board members, and associate/section editors in otorhinolaryngology journals indexed in the Web of Science SCI‐E core collection. We also analyzed the number of years the journals have been publishing, their categories (general otorhinolaryngology, otology‐audiology, phoniatrics, rhinology‐allergy), the country and continent of publication, the Journal Citation Indicator (JCI) 2021 values, 2‐year and 5‐year impact factors (IF), H‐index, and quartile rank of the journals.ResultsOut of the 54 editors‐in‐chief included in our study from a total of 44 journals, only 6 (11.1%) were women. Women constituted 21.6% of the editorial board members and 35.1% of the associate/section editors. The proportion of women in the editorial boards of journals with a 5‐year impact factor >3.0 was significantly higher compared to others. As the 5‐year impact factor of the journals increased, the number of women in the boards showed a linear increase. When evaluated based on journal categories, phoniatrics journals had higher representation of women in both editorial board membership and associate/section editor roles compared to other categories.ConclusionThe representation of women in the editorial boards of otorhinolaryngology journals is still inadequate. To rectify this situation, it is important for the entire academic community to exhibit a collective attitude rather than individual efforts.Level of Evidence2.
Effect of Functionalized Liquid Rubber on Mechanical Properties of an Epoxy Resin
Authors: Vertuccio Luigi , Guadagno Liberata , Barra Giuseppina , Arconati Vincenzo , Catauro Michelina 
Published: October 2023

AbstractIn this study, an epoxy resin has been modified with different weight ratios of carboxyl‐terminated polybutadiene liquid rubber. The introduction of a pre‐reaction catalyst has been necessary to promote the reaction between the epoxy groups and the carboxylic acid groups of carboxyl‐terminated butadiene acrylonitrile copolymer. The occurred reaction has been confirmed by infrared spectroscopy analysis. The analysis of the mechanical properties has shown that the presence of elastomeric domains allows obtaining a matrix with greater flexibility. This allows making the material competitive for many applications such as adhesives and composite matrices where a high fracture toughness is required.
Spectroscopic Investigation of Supramolecular Self‐Healing Resins Based on Covalently Modified Carbon Nanotubes
Authors: Guadagno Liberata , Raimondo Marialuigia , Longo Raffaele , Aliberti Francesca , Passaro Jessica , Piccirillo Annamaria , Calabrese Elisa 
Published: October 2023

AbstractIn this work, Fourier transform infrared spectroscopy (FTIR) is used as a valid method to support the study of supramolecular self‐healing composites, intended for structural applications. These nanocomposites are loaded with covalently functionalized multi wall carbon nanotubes (MWCNTs), which simultaneously impart to the material self‐healing ability, based on supramolecular chemistry, and electrical conductivity. FTIR analysis is carried out to demonstrate the success of the performed covalent modification, by identifying the functional groups bonded to the MWCNTs, and the presence of hydrogen bonding interactions established between the functional groups bonded to nano‐fillers and the hosting matrix.
Different Conformational Properties and Frequencies of Periodic Motion in the β‐ and γ‐Cyclodextrin
Authors: Raffaini Giuseppina , Ganazzoli Fabio 
Published: October 2023

AbstractCyclodextrins (CDs) are cyclic oligosaccharides with application in different fields. These systems can encapsulate hydrophobic molecules and allow their solubilization in water. CDs and CD complexes can self‐associate forming aggregate or micelle‐like structures. Theoretical studies based on molecular mechanics (MM) and molecular dynamics (MD) simulations are demonstrated to be a useful tool for understanding the conformational properties, the stability, their host–guest inclusion complexes in the solid state or in aqueous solution in a good agreement with experimental data. The aim of this work is to compare at atomistic level the conformational properties, the flexibility of the native β‐ and γ‐CD. The β‐CD shows very slightly deviation from C7 symmetry, and its glycosidic oxygens are on a flat plane, while in the γ‐CD they are in different arrangement on a curved plane. From the variation of the distance between opposite glycosidic oxygens in these CDs, the frequencies of motion due to periodic motions are calculated during MD run. These frequencies indicate faster periodic motion for the β‐CD and slower for the γ‐CD having larger dimension and less symmetrical structure. MD simulations are an interesting tool for investigating the flexibility of these systems, their possible periodic motion, and their frequencies of motion.
Benzoate‐Based Inhibitor Film to Prevent Chloride‐Induced Corrosion: Simulation Study of Efficiency of Dry or Hydrated Film
Authors: Raffaini Giuseppina , Bolzoni Fabio , Ormellese Marco 
Published: October 2023

AbstractIn the last 30 years, many synthetic organic substances have been proposed as promising inhibitors to prevent chloride‐induced corrosion in reinforced concrete structures. Using molecular mechanics (MM) and molecular dynamics (MD) methods the formation of protective film on steel have been investigated at atomistic level considering different organic inhibitors, comparing the theoretical results with experimental data. In previous work, the interaction between chlorides and both dry and hydrated triethylenetetramine (TETA) film on hydroxylated γ‐FeOOH surface is studied. Using the same simulation protocol, the aim of this work is to investigate the interaction between the Cl− ions and the benzoate inhibitor film to understand how the corrosion process can be avoided. The dry benzoate film efficiently prevents the adsorption of chlorides on lepidocrocite (γ‐FeOOH) surface. At the same time the MD simulations show the hydrated benzoate film have a lower efficiency because some chlorides come into contact with the γ‐FeOOH surface, and moreover, at longer time they cause a depletion of organic inhibitors close to them, then an inhomogeneity in the exposed film. Not only the number of chlorides that penetrate through the protective film must be considered but also the stability of dry or hydrated protective film during the time.
Comparative Studies between Two Plastic Materials Used in 3D Printing
Authors: Năstase Marian‐Sebastian , Costea Mihai , Jiga Gabriel , Alexandru Tudor George 
Published: October 2023

AbstractThis paper deals with the analysis and comparative studies of the two of the most used types of polymer filaments dedicated to the 3D printing industry. The study is focused on the mechanical, elastic, and thermal properties of two different types of plastic materials filaments – acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA) as well as on future development in various categories like industrial, medical, home decoration, and education. For carrying out this study, different specimens are printed using fused filament fabrication (FFF) technique, taking into account an infill percentage of 30% with a triangular shape as pattern type (internal structure).
Effect of Maleic Anhydride and Titanium Dioxide on the Miscibility of the PHBV/PP Mixture
Authors: Hamour Noura , Boukerrou Amar , Beaugrand Johnny 
Published: October 2023

AbstractThis study is interested in blends based on poly (hydroxybutyrate‐co hydroxyvalerate) (PHBV) and polypropylene (PP), using maleic anhydride (AM) as a compatibilizing agent and titanium dioxide (TiO2) acting as a filler in the matrix. In this work, the study of the miscibility of two polymers, as well as their physical mixtures is done. The results reveal that the immiscible PP/PHBV blend can be effectively accounted for by maleic anhydride. The latter is able to create chemical bonds between the macromolecular chains of the two polymers at the interface and therefore improve their properties.
Adaptive Scaling of Components in the Fused Deposition Modeling Process
Authors: Moritzer Elmar , Hecker Felix 
Published: October 2023

AbstractCurrently, the fused deposition modeling (FDM) process is the most common additive manufacturing technology. The principle of the FDM process is the strand wise deposition of molten thermoplastic polymers, by feeding a filament trough a heated nozzle. Due to the strand and layer wise deposition the cooling of the manufactured component is not uniform. This leads to dimensional deviations which may cause the component to be unusable for the desired application. In this paper, a method is described which is based on the shrinkage compensation through the adaption of every single raster line in components manufactured with the FDM process. The shrinkage compensation is based on a model resulting from a DOE which considers the main influencing factors on the shrinkage behavior of raster lines in the FDM process. An in‐house developed software analyzes the component and locally applies the shrinkage compensation with consideration of the boundary conditions, e.g., the position of the raster line in the component and the process parameters. Following, a validation using a simple geometry is conducted to show the effect of the presented adaptive scaling method.
Study of a Microsatelite Hinge Concept Using 3D Printed Prototypes
Authors: Stoica Marilena , Anania Florea Dorel , Zapciu Miron , Georgescu Luminita Elena 
Published: October 2023

AbstractThe CubeSat microsatellites are structures that can be found in many applications of industry and educations, but not only. Based on this, a new concept Card‐Sat structure is used in the present study. For a better understanding of the functionality microstructure Card‐Sat, this paper aims to study the geometry of joints manufactured from plastic materials by using the FFF 3D printing method and assembling to identify the suitable joint for this type of structures.
Effect of Mechanical Properties on the Miscibility of a PHBV/PP Blend
Authors: Hamour Noura , Boukerrou Amar , Beaugrand Johnny 
Published: October 2023

AbstractThe present work is dedicated to the study of the mechanical and rheological properties of poly (hydroxybutyrate‐co‐hydroxyvalerate) PHBV blends with polypropylene PP. Given the incompatibility of these homopolymers, the use of a compatibilizing agent is essential. For this purpose, titanium dioxide (TiO2) and maleic anhydride (MA) are used. These constituents are chosen on the basis of some work that showed a high compatibility between it and the two homopolymers PHBV and PP. Thus, this copolymer has a great potential to improve the interfacial adhesion between these two polymers. From the results obtained from the techniques used in this study, it can be concluded that the immiscible PP/PHBV mixture can be effectively compatibilizing for by maleic anhydride. The latter is able to create chemical bonds between the macromolecular chains of the two polymers at the interface and therefore improves their properties.
Development of Numerical Simulation Techniques for the Analysis of a Rollover Tractor
Authors: Felaco Amelia , Caputo Francesco , Lamanna Giuseppe 
Published: October 2023

AbstractOne of the leading causes of death in the word is the injury in the field of agriculture. Agricultural machinery, in fact, is very dangerous for workers and rollover accidents are due to several reasons. First, it must be considered that these machines operate on nonlinear land and on extremely steep slopes, so the causes are due to operational, tractor, and soil characteristics. Furthermore, recent studies have shown that in 33% of the rollovers that are analyzed, passive safety devices, such as seat belt, are not used by workers (who got thrown out of the safety zone). Another cause of fatal accidents is that, until now, the mechanical design of tractors has not provided for occupant protection. In fact, there are no standard tests that assess the safety of the occupant. This study aims to conduct an explicit finite element (FE) analysis of a rollover test of a generic T5 category tractor to assess the structural characteristics and the biomechanical performance of the occupant.
A 37–43.5 GHz front‐end MMIC for 5G high‐performance channel emulator in 0.1 μm GaAs pHEMT
Authors: Zhu Wentao , Chen Jixin , Nie Xinghe , Li Zekun , Hong Wei 
Published: October 2023

AbstractA front‐end MMIC working at 37–43.5 GHz for 5G high‐performance channel emulator is presented in this paper. The chip is fabricated in a 0.1‐μm commercial GaAs pHEMT process and integrated with a passive star mixer and a local oscillator (LO) chain, which is composed of a frequency tripler, a bandpass filter, a power amplifier, and an LO filter. The 10.5 GHz intermediate frequency (IF) signal is upconverted with the high frequency LO signal of 48–54 GHz through a passive double‐balanced star mixer, which can output 37–43.5 GHz radiofrequency signal. The high frequency LO can avoid the increase of bit error rate caused by the frequency band of input signal covering IF frequency. The conversion gain of −11.2 to −9.7 dB, the OP1‐dB of −0.26 to 1.7 dBm are achieved and the front‐end chip occupies an area of 2.78 × 0.9 mm2.
Improvement of LED‐based photoacoustic imaging using lag‐coherence factor (LCF) beamforming
Authors: Paul Souradip , Mulani Sufayan , Singh Mithun Kuniyil Ajith , Singh Mayanglambam Suheshkumar 
Published: October 2023

AbstractBackgroundOwing to its portability, affordability, and energy‐efficiency, LED‐based photoacoustic (PA) imaging is increasingly becoming popular when compared to its laser‐based alternative, mainly for superficial vascular imaging applications. However, this technique suffers from low SNR and thereby limited imaging depth. As a result, visual image quality of LED‐based PA imaging is not optimal, especially in sub‐surface vascular imaging applications.PurposeCombination of linear ultrasound (US) probes and LED arrays are the most common implementation in LED‐based PA imaging, which is currently being explored for different clinical imaging applications. Traditional delay‐and‐sum (DAS) is the most common beamforming algorithm in linear array‐based PA detection. Side‐lobes and reconstruction‐related artifacts make the DAS performance unsatisfactory and poor for a clinical‐implementation. In this work, we explored a new weighting‐based image processing technique for LED‐based PAs to yield improved image quality when compared to the traditional methods.MethodsWe are proposing a lag‐coherence factor (LCF), which is fundamentally based on the combination of the spatial auto‐correlation of the detected PA signals. In LCF, the numerator contains lag‐delay‐multiply‐and‐sum (DMAS) beamformer instead of a conventional DAS beamformer. A spatial auto‐correlation operation is performed between the detected US array signals before using DMAS beamformer. We evaluated the new method on both tissue‐mimicking phantom (2D) and human volunteer imaging (3D) data acquired using a commercial LED‐based PA imaging system.ResultsOur novel correlation‐based weighting technique showed LED‐based PA image quality improvement when it is combined with conventional DAS beamformer. Both phantom and human volunteer imaging results gave a direct confirmation that by introducing LCF, image quality was improved and this method could reduce side‐lobes and artifacts when compared to the DAS and coherence‐factor (CF) approaches. Signal‐to‐noise ratio, generalized contrast‐to‐noise ratio, contrast ratio and spatial resolution were evaluated and compared with conventional beamformers to assess the reconstruction performance in a quantitative way. Results show that our approach offered image quality enhancement with an average signal‐to‐noise ratio and spatial resolution improvement of around 20% and 25% respectively, when compared with conventional CF based DAS algorithm.ConclusionsOur results demonstrate that the proposed LCF based algorithm performs better than the conventional DAS and CF algorithms by improving signal‐to‐noise ratio and spatial resolution. Therefore, our new weighting technique could be a promising tool to improve the performance of LED‐based PA imaging and thus accelerate its clinical translation.