bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain anatomy of a clonal fish, the Amazon molly (Poecilia formosa): Effects of early-life environment
Authors: Nadema Hayo , Reich Tyler , Cunningham Debbie , Wong Elvis , Schlupp Ingo , Kotrschal Alexander 
Published: October 2023

Abstract

During ontogeny, environmental factors can impact the development of manifold traits that often aid in survival. This may include differential investment in brain regions in response to cognitive challenges. Especially the brain anatomy of fishes seems to respond readily to biotic and abiotic factors. However, we currently lack sufficient data to determine the extent to which such changes are consistent across species. To extend the phylogenetic breadth in this endeavour we studied how brain anatomy of Amazon mollies (Poecilia formosa) responds to the presence or absence of physical enrichment and/or social companions. The Amazon molly is a clonal species and genetically highly uniform, so that differences in brain anatomy of individuals from the same clonal lineage are most likely due to the environmental conditions provided, not to inherent genetic differences. We quantified brain anatomy by determining the volumes of six main brain regions (olfactory bulb; telencephalon; optic tectum; cerebellum; dorsal medulla; hypothalamus) and overall brain size. While brain anatomy was overall unaffected by the visual presence of a conspecific, we found that the cerebellum was larger in animals reared in an environmentally complex habitat. Our results corroborate the idea that usage of certain cognitive domains fosters enlargement in the region governing those.
Emotion Regulation from a Virtue Perspective
Authors: Kim Jeong Han , Chun Jina , Kim Jaeyoung , Ju Hyun-Ju , Kim Byung Jin , Jeong Jeongwoon , Lee Dong Hun 
Published: October 2023

Abstract
Background: The ability to regulate one’s emotional state is an important predictor of several behaviors such as reframing a challenging situation to reduce anger or anxiety, concealing visible signs of sadness or fear, or focusing on reasons to feel happy or calm. This capacity is referred to as emotion regulation. Deficits in this ability can adversely affect one’s adaptive coping, thus are associated with a variety of other psychopathological symptoms, including but not limited to depression, borderline personality disorder, substance use disorders, eating disorders, and somatoform disorders.
Methods: The present study examined emotion regulation in relation to the virtue-based psychosocial adaptation model (V-PAM). 595 participants were clustered based on their Difficulties in Emotion Regulation Scale (DERS) score, producing two clusters (i.e., high functioning vs. low functioning). Then, emotion regulation group membership was discriminated by using five V-PAM virtue constructs, including courage, integrity, practical wisdom, committed action, and emotional transcendence.
Results: Results show that five virtues contribute to differentiating group membership. Practical wisdom was the strongest contributor, followed by integrity, emotional transcendence, committed action, and courage. Predictive discriminant analysis was conducted and 71% of cases were correctly classified. A discussion of the relationship between emotion regulation and virtues was elaborated.
Conclusion: The concept of virtue holds significant importance in the comprehension of an individual's capacity to regulate their emotions, meriting future study.
Lipid-Lowering Drugs and Risk of Rapid Renal Function Decline: A Mendelian Randomization Study
Authors: Zhao Zhicheng , Wan Yu , Fu Han , Ying Shuo , Zhang Peng , Hayashi Shiki , Song Yu , Fu Naikuan 
Published: October 2023

Abstract

Background: Chronic kidney disease (CKD) patients face the risk of rapid kidney function decline leading to adverse outcomes like dialysis and mortality. Lipid metabolism might contribute to acute kidney function decline in CKD patients. Here, we utilized the Mendelian Randomization approach to investigate potential causal relationships between drug target-mediated lipid phenotypes and rapid renal function decline.
Methods: In this study, we utilized two methodologies: summarized data-based Mendelian randomization (SMR) and inverse variance-weighted Mendelian randomization (IVW-MR), to approximate exposure to lipid-lowering drugs. This entailed leveraging expression quantitative trait loci (eQTL) for drug target genes and genetic variants proximal to drug target gene regions, which encode proteins associated with low-density lipoprotein (LDL) cholesterol, as identified in genome-wide association studies. The objective was to investigate causal associations with the progression of rapid kidney function decline.
Results: The SMR analysis revealed a potential association between high expression of PCSK9 and rapid kidney function decline (OR=1.001, 95% CI= [1.11–1.23]; p=0.044). Similarly, IVW-MR analysis demonstrated a negative association between LDL cholesterol mediated by HMGCR and kidney function decline (OR=0.74, 95% CI=0.60–0.90; p=0.003).
Conclusion: Genetically predicted inhibition of HMGCR is linked with the progression of kidney function decline, while genetically predicted PCSK9 inhibition is negatively associated with kidney function decline. Future research should incorporate clinical trials to validate the relevance of PCSK9 in preventing kidney function decline.
Development and validation of hierarchical signature for precision individualized therapy based on the landscape associated with necroptosis in clear cell renal cell carcinoma
Authors: Yao Gao-sheng , Dai Jun-shang , Tan Zhi-ping , Dai Lei , Chen Wei , Luo Jun-Hang , Wei Jin-huan 
Published: October 2023

Abstract
Background
Increasing evidences show that necroptosis has a unique clinical significance in the occurrence and development of multiple diseases. Here, we systematically evaluated the role of necroptosis in clear cell renal cell carcinoma (ccRCC) and analyzed its regulatory patterns.
Results
We screened 97 necroptosis-related genes and demonstrated that they were dysregulated in ccRCC. Through Cox analysis and LASSO regression, a prognostic prediction signature including seven genes was built. Receiver operating characteristic (ROC) curves and Kaplan-Meier (KM) analyses both showed that the model was accurate, and univariate/multivariate Cox analysis showed that as an independent prognostic factor, the higher the risk score, the poorer the survival outcome. Besides, the predicted scores based on the signature were observably associated with immune-cell infiltration and mutation of specific genes. In addition, the risk score could potentially predict the patients’ responsiveness to different chemotherapy regimens. In specific, Nivolumab is more effective for patients with higher scores.
Conclusion
The necroptosis-related signature we constructed can accurately predict the prognosis of ccRCC patients, and further providing clues for targeted, individualized therapy.
Fluoroquinolone derivatives have a synergistic effect on the antifungal activity of echinocandins in Aspergillus fumigatus
Authors: Kang Suzie , Choi Jin-Ju , Lee Yoonseo , Lee Dong-Hyun , Yun Cheol-Won 
Published: October 2023

Abstract

The antifungal drugs of the echinocandins family showed high antifungal activity against A. fumigatus. However, echinocandins have a paradoxical effect and it is necessary to improve the paradoxical effect of echinocandins. To develop a new antifungal drug that improves the paradoxical effect of echinocandins, we performed a drug screening using a chemical library consisting of 8,000 unique chemicals with 0.5µg/ml of caspofungin. From the screening chemical library, we found that fluoroquinolone compounds activate the antifungal activity of caspofungin and no paradoxical effect of echinocandins was detected. 50 chemicals from the chemical library had a synergistic effect on the antifungal activity of caspofungin and among them, 16 compounds were fluoroquinolone derivative compounds with low antifungal activity when treated alone against A. fumigatus. NE-E07, which is one of the fluoroquinolone compounds we screened, showed a synergistic effect with all kinds of the echinocandins antifungal drugs, but no synergistic effect with other families of antifungal drugs such as voriconazole and amphotericin B. Furthermore, the quinolone antibiotics, which have a fluoroquinolone structure, did not show any synergistic effect with caspofungin. Finally, co-treatment of NE-E07 and caspofungin increased the viability of mice infected with A. fumigatus. These results indicate that the fluoroquinolone compounds we screened have a unique function of antifungal drugs and provide a new paradigm for antifungal drugs.
The host-guest system of resorcinolcalix[4]arene and pyridine-containing compounds: their syntheses, structures, antioxidant and antibacterial activity analyses
Authors: Chen Lu-Si , Zhou Xin-Min , Wang Qing , Jia Ai-Quan , Zhang Qian-Feng 
Published: October 2023

Abstract
Self-assembly of C-iso-butyl-resorcinolcalix[4]arene (CBCR) with 4-aminopyridine (4-AP) or 3-dimethylaminopyridine (3-DMAP) in ethanol afforded two host-guest complexes CBCR4-AP (1) and CBCR2(3-DMAP) (2), respectively. Complexes 1 and 2 were characterized by FT-IR, 1H NMR spectroscopies and single crystal X-ray diffraction analysis. The antioxidant and antibacterial experiments were conducted on complexes 1 and 2. The DPPH and ABTS free radical scavenging rate could reach 91.73% and 98.55% when the concentration of complex 2 was 500 and 31.25 mg/mL, respectively. The clearance rate of complex 1 for both free radicals is weaker than 2. When the concentration of 1 was 31.25 mg/mL, the ABTS free radical scavenging rate was 74.60%. The antibacterial test of complexes 1 and 2 showed that the antibacterial circle diameter of complex 1 against Escherichia coli was 10.25 mm, with a MIC value of 12.5 mg/mL, and the antibacterial circle diameter against Staphylococcus aureus was 14.33 mm with a MIC value of 3.12 mg/mL; complex 2 has a diameter of 11.27 mm and a MIC value of 12.5 mg/mL for Escherichia coli, and a diameter of 16.40 mm and a MIC value of 1.56 mg/mL for Staphylococcus aureus. Co-crystallization of pyridine-containing compounds and CBCR might enhance antioxidant and antibacterial activity.
Computational investigations of potential inhibitors of Monkeypox virus envelope protein E8 through molecular docking and molecular dynamics simulations
Authors: Das Rohit , Bhattarai Anil , Karn Rohit , Tamang Buddhiman 
Published: October 2023

Abstract
Monkeypox has recently surfaced as a global public health issue, and the virus has spread rapidly worldwide in the post-COVID-19 period. These emerging infections affect human health and hinder the advancement of the socio-economic conditions of the affected countries. There are currently no authorized medications to treat this condition. As a result, this study gap motivates us to seek a viable inhibitor from a natural source. In the present study, some plant-derived compounds and commercialized drugs were investigated using computational approaches to identify the potent monkeypox virus envelope protein E8 inhibitors. Docking analysis revealed that punicalagin has a greater affinity for the target protein (-9.1 kcal/mol) when compared to the control drug maraviroc (-7.4 kcal/mol). The protein-ligand interaction dynamics were computed using 100 ns molecular dynamics simulations. MD results demonstrated better stability of punicalagin with the target envelope protein, compared to the control drug maraviroc. This finding was validated by decreased RMSD, RMSF, Rg, and SASA with increased H-bonding in the MPVX E8-punicalagin complex. Thus, we hypothesize that punicalagin may act as a potent inhibitor of monkeypox virus.
Simultaneously enhancing microelastic response and degradability for poly(butylene succinate) composite monofilaments by silanized microcrystalline cellulose
Authors: Zhang Yang , Liao He , Zhang Yue , Zhang Yumei 
Published: October 2023

Abstract

With the increasing demand for environmentally friendly and sustainable materials, research on cellulose/bio-based polyester composites has received increasing attention. However, the hydrophilicity of cellulose remains a major factor in its poor interaction with hydrophobic bio-based polyester. To prepare microcrystalline cellulose (MCC)/poly(butylene succinate) (PBS) composite monofilaments with high cellulose content to suppress the deformation of PBS, hexadecyltrimethoxysilane (KH1631) was selected for surface silylation of MCC in a mass ratio of 1:0.5 based on the principle of polarity similarity. The physical-chemical double crosslinking of KH1631 with MCC enhanced the interface bonding of MCC and PBS, so the composite monofilaments with mMCC content up to 35 wt% were prepared by melt spinning. After multi-stage and high-ratio thermal stretching, mMCC/PBS composite monofilaments exhibited uniformly distributed microporous structure, as well as double yield behaviors and microelastic response, indicating that mMCC/PBS composite monofilaments exhibited excellent tensile elasticity, fatigue resistance, and lower residual strains under small deformation (15%). Notably, the addition of 15–35 wt% mMCC increased the degradability of mMCC/PBS composite monofilaments following 100 days of treatment in an aqueous environment and 180 days of burial in soil. Overall, our work has significantly enhanced the compatibility between MCC and PBS without the use of any high-cost modifiers or complex processing methods, and successfully developed mMCC/PBS composite monofilaments that exhibit excellent dimensional stability during use and quick degradation after disposal.
Trends and Forecasts of Industrial Carbon Emission Changes in China's Major Energy Provinces
Authors: Lu Ying , Li Xudong 
Published: October 2023

Abstract

The industrial sector is an important source of carbon emissions. This study took Guizhou Province as an example, and based on the energy balance sheet and national and Guizhou provincial statistical data, the IPCC method was used to measure the industrial carbon emissions of Guizhou Province from 2000 to 2021.The STIRPAT model,ridge regression model and scenario analysis method predicted the industrial carbon emissions in Guizhou province from 2022 to 2060.The results showed that (1) during the period of 2000–2021, the total amount of industrial carbon emissions in Guizhou Province was generally on the rise, and the carbon emission intensity experienced a trend of increasing and then changing; (2) the industrial energy consumption structure in Guizhou Province is dominated by coal and electricity, but the proportion of coal has declined in recent years, and the proportion of electricity has risen with fluctuations; and (3) different scenarios reached peak emissions in 2030–2038. The low-carbon scenario corresponded to the smallest peak, will peak in 2030. The uncontrolled inertia scenario and the energy-saving scenario, with smaller emission reductions, were unable to realize the "dual-carbon" target.
WITHDRAWN: Ciprofol Suppresses Glycolysis and Epithelial-Mesenchymal Transition (EMT) in Colorectal Cancer Cells by Activating Adenomatous Polyposis Coli to Modulate the Wnt/β- catenin Signaling Pathway
Authors: Wu Han , Gao Jiening , Wang Yong , Zhang Yao , Jia Li , Li Weijing 
Published: October 2023

Abstract
Propofol, frequently employed as a perioperative anesthetic for patients with colorectal cancer, has been documented to demonstrate anticancer properties. Ciprofol, an innovative anesthetic derived from propofol, showcases unexplored impacts on the viability of colorectal cancer cells. To investigate the impact of ciprofol on glycolysis and epithelial-mesenchymal transition (EMT) in colorectal cancer cells and its role in the Wnt/β-catenin signaling pathway. In vitro experiments were conducted utilizing cell counting kit-8 (CCK-8), scratch assays, and Transwell assays to assess the impact of ciprofol on the proliferation, invasion, and migration of colorectal cancer cells. Downregulation of adenomatous polyposis coli (APC) expression was utilized to ascertain the potential reversal of ciprofol's inhibitory effects. Lactate and glucose levels were assessed using assay kits in KYSE30 cells. Western blot analysis was employed to assess the expression levels of Wnt/β-catenin signaling pathway components, invasion-related proteins, and mRNA in colorectal cancer cells. In vivo experiments involved establishing a xenograft mouse model to verify the effects of ciprofol on HT29 cells. In vitro experiments demonstrated that ciprofol suppressed the EMT process and glycolysis in colorectal cancer cells. Ciprofol activated APC protein, and downregulation of APC mitigated the inhibitory effects of ciprofol on colorectal cancer cells. Ciprofol suppressed the Wnt/β-catenin signaling pathway, downregulated the protein expression of Hexokinase 2 (HK2), Lactate Dehydrogenase A (LDHA), Matrix Metalloproteinase 2 (MMP2), Matrix Metalloproteinase 9 (MMP9), and E-cadherin, and upregulated N-cadherin protein expression. In vitro experiments also revealed that ciprofol inhibited tumor growth in xenograft mice, with protein expression changes consistent with in vivo results. Ciprofol suppresses the EMT process and glycolysis in colorectal cancer cells. Furthermore, ciprofol may exert its anticancer effects by activating APC to inhibit the Wnt/β-catenin signaling pathway.
Highly Stretchable Biobased Poly(butylene succinate) Elastomer Copolymerized with Naphthalate-Monomer-Derived Shape Memory having Self-healing Properties
Authors: Mao Hsu-I , Chang Shih-Hung , Chen Chin-Wen 
Published: October 2023

Abstract
In this study, a series of poly(butylene succinate)-based copolymers containing various quantities of dimethyl 2,6-naphthalene dicarboxylate (NDC) were synthesized via melt polymerization. The thermal stabilities of the copolymers were maintained, while a slight increment in the stability was observed as the NDC content increased. The results of differential scanning calorimetry and wide-angle X-ray diffraction demonstrated a reduction in the crystallizability of the copolymers with increasing NDC concentration. Unexpectedly, the tensile tests showed significant enhancement of the elongation rate from 122.5 to 2645.0% as the NDC content increased from 0 to 32 mol%. Samples with 28, 30, and 32 mol% NDC showed remarkable abilities with recovery rates above 90% after three test cycles. Moreover, apparent cut mark repairing behaviors were observed under 70°C heating in samples containing 25, 28, and 30 mol% NDC. These results indicate the potential of the copolymers for self-healing and highly stretchable shape memory wound dressing material applications.
Follitropin delta combined with menotropin in patients at risk for poor ovarian response during in vitro fertilization cycles: a prospective controlled clinical study
Authors: Duarte-Filho Oscar , Miyadahira Eduardo , Matsumoto Larissa , Yamakami Lucas , Tomioka Renato , Podgaec Sergio 
Published: October 2023

Abstract
Background
The maximum daily dose of follitropin delta for ovarian stimulation in the first in vitro fertilization cycle is 12 µg (180 IU), according to the algorithm developed by the manufacturer, and based on patient's ovarian reserve and weight. This study aimed to assess whether 150 IU of menotropin combined with follitropin delta improves the response to stimulation in women with serum antimullerian hormone levels less than 2.1 ng/mL.
Methods
This study involved a prospective intervention group of 44 women who received 12 µg of follitropin delta combined with 150 IU of menotropin from the beginning of stimulation and a retrospective control group of 297 women who received 12 µg of follitropin delta alone during the phase 3 study of this drug. The inclusion and exclusion criteria and other treatment and follow-up protocols in the two groups were similar. The pituitary suppression was achieved by administering a gonadotropin-releasing hormone (GnRH) antagonist. Ovulation triggering with human chorionic gonadotropin or GnRH agonist and the option of transferring fresh embryos or using freeze-all strategy were made according to the risk of developing ovarian hyperstimulation syndrome.
Results
Women who received follitropin delta combined with menotropin had higher estradiol levels on trigger day (2,150 pg/mL vs. 1,373 pg/mL, p < 0.001), more blastocysts (3.1 vs. 2.4, p = 0.003) and more top-quality blastocysts (1.8 vs. 1.3, p = 0.017). No difference was observed in pregnancy, implantation, miscarriage, and live birth rates after the first embryo transfer. The incidence of ovarian hyperstimulation syndrome did not differ between the groups. However, preventive measures for the syndrome were more frequent in the group using both drugs than in the control group (13.6% vs. 0.6%, p < 0.001).
Conclusions
In women with serum antimullerian hormone levels less than 2.1 ng/mL, the administration of 150 IU of menotropin combined with 12 µg of follitropin delta improved the ovarian response, making it a valid therapeutic option in situations where ovulation triggering with a GnRH agonist and freeze-all embryos strategy can be used routinely.
Trial registration:
U1111-1247-3260 (Brazilian Register of Clinical Trials, available at https://ensaiosclinicos.gov.br/rg/RBR-2kmyfm)
Negative capacitance effect using a pure imaginary electric mobility controled by an adiabatic parameter in thin film materials based on Drude model
Authors: NOUPEYI S. D. , JIOTSA A. KENFACK 
Published: October 2023

Abstract
Existence of a pure imaginary mobility of charge carriers in organic polymers materials, precisely the poly p-phenylene vinylene is explored in this work. Indeed, we propose a new model of dynamic equation of particles able to carry electric charges, we introduce a control parameter of the adiabatic evolution combined with a phase difference between the external perturbation of the material and the position of carrier, leading from then on to the non-use of the complex mobility. This model after transformation allowed us to demonstrate the existence of negative capacitance at low and high frequencies in the poly p-phenylene vinylene. Also thanks to this new model, we were able to obtain results in line with the experimental ones, thus confirming the validity of our model.
Teaching quantum mechanics to electrical engineering students
Authors: Bonilla-Licea Moise , E. Moises Bonilla 
Published: October 2023

Abstract
The second quantum revolution is taking place nowadays with quantum computing and quantum communications. This implies the necessity of providing to electrical engineering students, not necessarily physicists, a clear presentation of the quantum theory in the least amount of time. Since the publication of Dirac's book, in 1930, there has been different approaches to introduce quantum mechanics. Nevertheless, they are all based on the assumption of the physics students syllabus, and not on the conventional knowledge of electrical engineering students. For this reason, in the present work it is proposed a presentation, addressed to electrical engineering students, to approach the quantum formalism, by means of matrix algebra and Fourier series, which are familiar topics for electrical engineering students.