bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Intratympanic and Systemic Steroid Therapy as Primary Treatments for Idiopathic Sudden Sensorial Hearing Loss
Authors: Fuji Sayaka , Takeuchi Ayako , Kariya Akifumi , Akisada Naoki , Koyama Takahisa , Fujisawa Iku , Hamada Koji , Ishihara Hisashi , Akagi Seiko 
Published: November 2023

AbstractRecently, intratympanic steroid (ITS) therapy has been used as a primary or salvage treatment for idiopathic sudden sensorineural hearing loss (ISSHL). In the present study, we retrospectively compared the efficacies of ITS and systemic steroid (SS) therapies as primary treatments for ISSHL. This study included 112 patients treated for ISSHL at our hospital, of which 44 received ITS therapy and 68 received SS therapy. Regarding patient background characteristics, the mean age (76 vs. 65 years, p < 0.0001) and percentage of patients with diabetes mellitus (55 vs. 18%, p < 0.0001) were significantly higher in the ITS group than in the SS group, whereas the rate of prior steroid use was lower in the ITS group than in the SS group (9 vs. 31%, p = 0.0068). After 3 weeks, the treatment response was cure, marked recovery, recovery, and no change in 11, 9, 8, and 16 patients in the ITS group and 32, 11, 5, and 20 patients in the SS group, respectively. Accordingly, the SS group was found to have a significantly higher cure rate than the ITS group (47 vs. 25%, p = 0.0191), with similar findings after propensity score matching (48 vs. 22%, p = 0.0461). Therefore, SS therapy is recommended as a primary treatment for ISSHL in patients who are not old or at a high risk of SS therapy-associated complications.
The Relationship between Gestational Weight Gain and Cesarean Delivery among Patients undergoing Induction of Labor
Authors: Bender Whitney R. , Hamm Rebecca F. , Dolin Cara , Levine Lisa D. 
Published: November 2023

Objective This study aimed to determine the impact of pregnancy weight gain above National Academy of Medicine (NAM) guidelines on cesarean delivery rates following induction.
Study Design This is a secondary analysis of a prospective cohort study of patients who underwent induction at a single tertiary care center between July 2017 and July 2019. Included in the primary study were patients undergoing term (≥37 weeks) labor induction with a singleton gestation, intact membranes, and unfavorable cervical examination (Bishop score of ≤6 and cervical dilation ≤ 2 cm). Eligibility for this analysis was limited to patients with a documented prenatal body mass index (BMI) < 20 weeks' gestation. The primary exposure was gestational weight gain greater than NAM guidelines (WGGG) for a patient's initial BMI category. The primary outcome was cesarean delivery for any indication.
Results Of 1,610 patients included in the original cohort, 1,174 (72.9%) met inclusion criteria for this analysis and 517 (44.0%) of these had weight gain above NAM guidelines. Of the entire cohort, 60.0% were Black and 52.7% had private insurance. In total, 160 patients (31%) with WGGG underwent cesarean compared with 127 patients (19.3%) without WGGG (p < 0.001), which equates to a 59% increased odds of cesarean when controlling for initial BMI category, parity, gestational diabetes, and indication for induction (Adjusted Odds Ratio [aOR] 1.58, 95% confidence interval [CI] 1.17–2.12). Among only nulliparous patients, WGGG was associated with an increased odds of cesarean (26.4 vs. 38.2%, aOR 1.50, 95% CI 1.07–2.10). In multiparous patients, however, there was no difference in cesarean between those with and without WGGG (8.8 vs. 14.1%, aOR 1.85, 95% CI 0.96–3.58).
Conclusion This study demonstrates that weight gain above NAM guidelines is associated with more than a 50% increased odds of cesarean. Patients should be informed of this association as gestational weight gain may be a modifiable risk factor for cesarean delivery.
Key Points
Dating “Sweet Desire”
Authors: Wise Dennis Wilson 
Published: November 2023

Abstract
C. S. Lewis and J. R. R. Tolkien are two key figures in the Modern Alliterative Revival, and each sought to revive Old English poetics with close to absolute metrical fidelity. While scholarship on Tolkien’s alliterative verse has seen an uptick in recent years, though, Lewis remains the odd poet out. Nominally, this article attempts to assign a composition date for Lewis’s poem “Sweet Desire.” My dating to early 1930 associates this text with Lewis’s famous conversion to theism. More broadly, this article tracks one revivalist’s painstaking adaptation of the alliterative meter into Modern English, outlining the technical challenges faced by Lewis and which other contemporary revivalists must overcome as well.
Techno-economic analysis of a hybrid renewable energy system integrated with productive activities in an underdeveloped rural region of eastern Indonesia
Authors: Shafira Alya Nurul , Petrana Subhan , Muthia Rahma , Purwanto Widodo Wahyu 
Published: November 2023

Abstract
The Southwest Maluku region in eastern Indonesia is considered a frontier, outermost and underdeveloped region. Its inhabitants live on isolated islands, including the residents of Mahaleta Village, where only 9.4% of the community have limited access to electricity. This study aimed to design an economically feasible hybrid renewable energy (RE) system based on solar and wind energy to integrate with the productive activities of the village. The study developed conceptual schemes to meet the demand for electricity from the residential, community, commercial and productive sectors of the village. The analysis was performed using a techno-economic approach. The hybrid system was designed using the HOMER Pro optimization function, and cold-storage and dryer systems were designed to support related productive activities. The optimized design of the hybrid RE system comprised 271.62 kW of solar photovoltaics, 80 kW of wind turbines and a 1-MWh lead–acid battery. We found that the hybrid RE system would only be economically feasible with a full-grant incentive and an electricity tariff of $0.0808/kWh. However, the productive activity schemes were all economically feasible, with a cold-storage cost of $0.035/kg and a drying cost of $0.082/kg. Integrating the hybrid RE system with productive activities can improve the economic feasibility of the energy system and create more jobs as well as increase income for the local community.
Genetic analysis of a genus of plant mimics (Alseuosmia A.Cunn; Alseuosmiaceae) reveals incongruence between morphology and phylogeny and possible mimetic polymorphism
Authors: Shepherd Lara D , Townsend Andrew , de Lange Peter J , Perrie Leon R 
Published: November 2023

Abstract
Alseuosmia (Alseuosmiaceae) is an endemic New Zealand genus of small trees and shrubs, which is unusual in that some taxa appear to morphologically mimic unrelated species. The taxonomy of the group has long been debated, with the extreme morphological diversity in A. banksii causing much of the confusion. Here we use ddRADseq to examine the genetic relationships between species of the genus, with a particular focus on the morphological forms of A. banksii. Our analyses revealed that for species in the northern part of the distribution, genetic relationships largely matched geography rather than species boundaries based on morphology, and that hybridization between morphs appears to be common. A diversity of morphologies is present within these northern Alseuosmia, including multiple forms that appear to mimic unrelated genera, and these may constitute a single gene pool. Further south, two species (A. turneri and A. pusilla) were genetically distinct in sympatry. We suggest maintaining the current taxonomy until further research can be undertaken.
Mitochondrial aminoacyl-tRNA synthetases trigger unique compensatory mechanisms in neurons
Authors: Podmanicky Oliver , Gao Fei , Munro Benjamin , Jennings Matthew J , Boczonadi Veronika , Hathazi Denisa , Mueller Juliane S , Horvath Rita 
Published: November 2023

AbstractMitochondrial aminoacyl-tRNA synthetase (mt-ARS) mutations cause severe, progressive, and often lethal diseases with highly heterogeneous and tissue-specific clinical manifestations. This study investigates the molecular mechanisms triggered by three different mt-ARS defects caused by biallelic mutations in AARS2, EARS2, and RARS2, using an in vitro model of human neuronal cells. We report distinct molecular mechanisms of mitochondrial dysfunction among the mt-ARS defects studied. Our findings highlight the ability of proliferating neuronal progenitor cells (iNPCs) to compensate for mitochondrial translation defects and maintain balanced levels of oxidative phosphorylation (OXPHOS) components, which becomes more challenging in mature neurons. Mutant iNPCs exhibit unique compensatory mechanisms, involving specific branches of the integrated stress response, which may be gene-specific or related to the severity of the mitochondrial translation defect. RNA sequencing revealed distinct transcriptomic profiles showing dysregulation of neuronal differentiation and protein translation. This study provides valuable insights into the tissue-specific compensatory mechanisms potentially underlying the phenotypes of patients with mt-ARS defects. Our novel in vitro model may more accurately represent the neurological presentation of patients and offer an improved platform for future investigations and therapeutic development.
Epigenomic profiling of the infrapatellar fat pad in osteoarthritis
Authors: Kreitmaier Peter , Park Young-Chan , Swift Diane , Gilly Arthur , Wilkinson J Mark , Zeggini Eleftheria 
Published: November 2023

Abstract
Osteoarthritis is a prevalent, complex disease of the joints, and affects multiple intra-articular tissues. Here, we have examined genome-wide DNA methylation profiles of primary infrapatellar fat pad and matched blood samples from 70 osteoarthritis patients undergoing total knee replacement surgery. Comparing the DNA methylation profiles between these tissues reveal widespread epigenetic differences. We produce the first genome-wide methylation quantitative trait locus (mQTL) map of fat pad, and make the resource available to the wider community. Using two-sample Mendelian randomization and colocalization analyses, we resolve osteoarthritis GWAS signals and provide insights into the molecular mechanisms underpinning disease aetiopathology. Our findings provide the first view of the epigenetic landscape of infrapatellar fat pad primary tissue in osteoarthritis.
Effects of automation on the gender pay gap: the case of Estonia
Authors: Pavlenkova Ilona , Alfieri Luca , Masso Jaan 
Published: November 2023

Abstract
This paper investigates how investments in automation affect the gender pay gap. The evidence of the effects of automation on the labor market is growing; however, little is known about the implications of automation for the gender pay gap. The data used in this paper are from a matched employer–employee dataset incorporating detailed information on firms, their imports, and employee–level data for Estonian manufacturing and service employers for the period of 2006–2018. Through the use of the imports of automation goods as a proxy for the introduction of automation at the firm level, this paper estimates the effect of automation using simple Mincerian wage equations. The causality of the effect is further validated using propensity score matching (PSM). We find that introducing automation enlarges the gender pay gap, and PSM confirms that this also has a higher causal effect on the wages of male employees than female employees. The results imply that a higher representation of women in higher-paid positions does not guarantee a reduction in the gender pay gap in the presence of automation, and appropriate measures in education and retraining are needed to tackle the effect of automation on gender inequality.
The impact of second transurethral resection on survival outcomes in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette–Guérin therapy
Authors: Kikuchi Hiroshi , Abe Takashige , Miyake Makito , Miyata Haruka , Matsumoto Ryuji , Osawa Takahiro , Nishimura Nobutaka , Fujimoto Kiyohide , Inokuchi Junichi , Yoneyama Takahiro , Tomida Ryotaro , Numakura Kazuyuki , Matsushita Yuto , Matsumoto Kazumasa , Sato Takuma , Taoka Rikiya , Kobayashi Takashi , Kojima Takahiro , Matsui Yoshiyuki , Nishiyama Naotaka , Kitamura Hiroshi , Nishiyama Hiroyuki , Shinohara Nobuo 
Published: November 2023

Abstract

Objective
Several guidelines recommended that second transurethral resection should be performed in patients with diagnosis of high-risk non-muscle-invasive bladder cancer. However, therapeutic benefits of second transurethral resection before bacillus Calmette–Guérin intravesical instillation were conflicting amongst previous studies. We investigated the prognostic impact of second transurethral resection before bacillus Calmette–Guérin instillation in high-risk non-muscle-invasive bladder cancer patients.

Methods
This retrospective study included 3104 non-muscle-invasive bladder cancer patients who received bacillus Calmette–Guérin instillations between 2000 and 2019 at 31 collaborative institutions. Univariate and multivariate Cox proportional hazards models were used to assess the risk factors of intravesical recurrence, disease progression, cancer-specific mortality and overall mortality.

Results
In the entire population, patients undergoing second transurethral resection (33%, 1026/3104) had a lower risk of intravesical recurrence on univariate analysis (hazard ratio 0.85, 95% confidence interval 0.73–0.98, P = 0.027), although it did not remain significant on multivariate analysis (hazard ratio 0.90, 95% confidence interval 0.76–1.07, P = 0.24). Subgroup analysis revealed that, in pT1 patients (n = 1487), second transurethral resection was significantly correlated with a lower risk of intravesical recurrence on multivariate analysis (hazard ratio 0.80, 95% confidence interval 0.64–1.00, P = 0.048), but lower risks of disease progression (hazard ratio 0.75, 95% confidence interval 0.56–1.00, P = 0.049), cancer-specific mortality (hazard ratio 0.54, 95% confidence interval 0.35–0.85, P = 0.007) and overall mortality (hazard ratio 0.73, 95% confidence interval 0.55–0.97, P = 0.027) on univariate analysis.

Conclusions
Second transurethral resection confers accurate pathological staging and could be used to safely select good candidates for intravesical bacillus Calmette–Guérin instillation. We further confirm that second transurethral resection could confer an oncological benefit in pT1 bladder cancer patients treated by bacillus Calmette–Guérin instillation, and so strongly recommend second transurethral resection in this patient population.
Plant age-dependent dynamics of annatto pigment (bixin) biosynthesis in Bixa orellana
Authors: Machado Kleiton Lima de Godoy , Faria Daniele Vidal , Duarte Marcos Bruno Silva , Silva Lázara Aline Simões , de Oliveira Tadeu dos Reis , Falcão Thais Castilho Arruda , Batista Diego Silva , Costa Marcio Gilberto Cardoso , Santa-Catarina Claudete , Silveira Vanildo , Romanel Elisson , Otoni Wagner Campos , Nogueira Fabio Tebaldi Silveira 
Published: November 2023

Abstract
Age affects the production of secondary metabolites, but how developmental cues regulate secondary metabolism remains poorly understood. The achiote tree (Bixa orellana L.) is a source of bixin, an apocarotenoid used in diverse industries worldwide. Understanding how age-dependent mechanisms control bixin biosynthesis is of great interest for plant biology and for economic reasons. Here we overexpressed miRNA156 (miR156) in B. orellana to comprehensively study the effects of the miR156–SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) module on age-dependent bixin biosynthesis in leaves. Overexpression of miR156 in annatto plants (miR156ox) reduced BoSPL transcript levels, impacted leaf ontogeny, lessened bixin production, and increased abscisic acid levels. Modulation of expression of BoCCD4-4 and BoCCD1, key genes in carotenoid biosynthesis, was associated with diverting the carbon flux from bixin to abscisic acid in miR156ox leaves. Proteomic analyses revealed an overall low accumulation of most secondary metabolite-related enzymes in miR156ox leaves, suggesting that miR156-targeted BoSPLs may be required to activate several secondary metabolic pathways. Our findings suggest that the conserved BomiR156–BoSPL module is deployed to regulate leaf dynamics of bixin biosynthesis, and may create novel opportunities to fine-tune bixin output in B. orellana breeding programs.
An essential role for mannan degradation in both cell growth and secondary cell wall formation
Authors: Zhang Rui , Li Bo , Zhao Yunjun , Zhu Yingying , Li Laigeng 
Published: November 2023

Abstract
Coordination of secondary cell wall deposition and cell expansion during plant growth is required for cell development, particularly in vascular tissues. Yet the fundamental coordination process has received little attention. We observed that the Arabidopsis endo-1,4-mannanase gene, AtMAN6, is involved in the formation of cell walls in vascular tissues. In the inflorescence stem, the man6 mutant had smaller vessel cells with thicker secondary cell walls and shorter fiber cells. Elongation growth was reduced in the root, and secondary cell wall deposition in vessel cells occurred early. Overexpression of AtMAN6 resulted in the inverse phenotypes of the man6 mutant. AtMAN6 was discovered on the plasma membrane and was specifically expressed in vessel cells during its early development. The AtMAN6 protein degraded galactoglucomannan to produce oligosaccharides, which caused secondary cell wall deposition in vessel and fiber cells to be suppressed. Transcriptome analysis revealed that the expression of genes involved in the regulation of secondary cell wall synthesis was changed in both man6 mutant and AtMAN6 overexpression plants. AtMAN6’s C-terminal cysteine repeat motif (CCRM) was found to facilitate homodimerization and is required for its activity. According to the findings, the oligosaccharides produced by AtMAN6 hydrolysis may act as a signal to mediate this coordination between cell growth and secondary cell wall deposition.
Observation of a propagating slow magnetoacoustic wave in a coronal plasma fan with SDO/AIA and SolO/EUI
Authors: Meadowcroft Rebecca L , Zhong Sihui , Kolotkov Dmitrii Y , Nakariakov Valery M 
Published: November 2023

ABSTRACT
Simultaneous observations of a propagating disturbance of EUV intensity, with SDO/AIA at 171 Å and SolO/EUI-HRIEUV at 174 Å, are investigated. The disturbance moves outwards along a plasma fan structure in active region AR 12941 on February 7th 2022, at 12:45–14:15 UT. The spacecraft line-of-sight separation is 19°. The variation of the EUV intensity resembles an almost harmonic wave with an oscillation period of $2.7^{+0.1}_{-0.2}$ and $2.6^{+0.1}_{-0.1}$ min for AIA and HRIEUV, respectively. Over 30 oscillation cycles are detected. The wave originated at the footpoint of the fan, anchored in a sunspot. The projected phase speeds are 60.5 ± 5.2 and 74.4 ± 6.2 km s−1 in the AIA and HRIEUV data, respectively, determined by the cross-correlation technique. The observed parameters of the propagating EUV disturbance suggest its interpretation as a slow magnetoacoustic wave. Observations with AIA show that the wave decays with height, with a calculated e-folding length of $6.9^{+1.3}_{-0.8}$ Mm. In contrast, in the HRIEUV data, the propagating EUV disturbance is also seen much higher, with the e-folding length of $12.8^{+1.1}_{-1.7}$ Mm. This observation demonstrates, for the first time, that the apparent spatial damping of propagating slow waves depends on the observational instrument. Moreover, our work shows that the study of slow waves can be advanced with the use of HRIEUV, and multiple instruments with non-parallel lines of sight.
Hierarchical Bayesian inference of globular cluster properties
Authors: Wen Robin Y , Speagle Joshua S , Webb Jeremy J , Eadie Gwendolyn M 
Published: November 2023

ABSTRACTWe present a hierarchical Bayesian inference approach to estimating the structural properties and the phase-space centre of a globular cluster (GC) given the spatial and kinematic information of its stars based on lowered isothermal cluster models. As a first step towards more realistic modelling of GCs, we built a differentiable, accurate emulator of the lowered isothermal distribution function using interpolation. The reliable gradient information provided by the emulator allows the use of Hamiltonian Monte Carlo methods to sample large Bayesian models with hundreds of parameters, thereby enabling inference on hierarchical models. We explore the use of hierarchical Bayesian modelling to address several issues encountered in observations of GC including an unknown GC centre, incomplete data, and measurement errors. Our approach not only avoids the common technique of radial binning but also incorporates the aforementioned uncertainties in a robust and statistically consistent way. Through demonstrating the reliability of our hierarchical Bayesian model on simulations, our work lays out the foundation for more realistic and complex modelling of real GC data.
The cluster mass function and the σ8 tension
Authors: Papageorgiou A , Plionis M , Basilakos S , Abdullah M H 
Published: November 2023

ABSTRACT
We use a large set of halo mass function (HMF) models in order to investigate their ability to represent the observational cluster mass function (CMF), derived from the $\tt {GalWCat19}$ cluster catalogue, within the Lambda cold dark matter (ΛCDM) cosmology. We apply the χ2 minimization procedure to constrain the free parameters of the models, namely Ωm and σ8. We find that all HMF models fit well the observational CMF, while the Bocquet et al. model provides the best fit, with the lowest χ2 value. Utilizing the index of inconsistency (IOI) measure, we further test the possible inconsistency of the models with respect to a variety of Planck 2018 ΛCDM cosmologies, resulting from the combination of different probes (CMB–BAO or CMB–DES). We find that the HMF models that fitted well the observed CMF provide consistent cosmological parameters with those of the Planck CMB analysis, except for the Press and Schechter, Yahagi et al., and Despali et al. models that return large IOI values. The inverse $\chi _{\rm min}^2$-weighted average values of Ωm and σ8, overall 23 theoretical HMF models are ${\bar{\Omega }_{m,0}}=0.313\pm 0.022$ and ${\bar{\sigma }_8}=0.798\pm 0.040$, which are clearly consistent with the results of Planck–CMB, providing S8 = σ8(Ωm/0.3)1/2 = 0.815 ± 0.05. Within the ΛCDM paradigm and independently of the selected HMF model in the analysis, we find that the current CMF shows no σ8 tension with the corresponding Planck–CMB results.
Tidal dissipation in satellites prevents Hill sphere escape
Authors: Kisare A M , Fabrycky D C 
Published: November 2023

ABSTRACT
The transit method is a promising means of detecting exomoons, but few candidates have been identified. For planets close to their stars, the dynamical interaction between a satellite’s orbit and the star must be important in their evolution. Satellites beyond synchronous orbit spiral out due to the tide raised on their planet, and it has been assumed that they would likely escape the Hill sphere. Here we follow the evolution with a three-body code that accounts for tidal dissipation within both the planet and the satellite. We show that tidal dissipation in satellites often keeps them bound to their planet, making exomoons more observable than previously thought. The probability of escape depends on the ratio of tidal quality factors of the planet and satellite; when this ratio exceeds 0.5, escape is usually avoided. Instead, the satellite moves to an equilibrium in which the spin angular momentum of the planet is not transferred into the orbit of the satellite, but is transferred into the orbit of the planet itself. While the planet continues spinning faster than the satellite orbits, the satellite maintains a semi-major axis of approximately 0.41 Hill radii. These states are accompanied with modest satellite eccentricity near 0.1 and are found to be stable over long time-scales.