bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lupus panniculitis as the initial presentation of systemic lupus erythematosus triggered by COVID-19 infection: case report and literature review
Authors: Abuhammad Aseel , AbuKhalaf Salsabeel M , AbuKhalaf Muhammad M , Janem Abdelrhman Muwafaq , Attawna Saed I Y 
Published: November 2023

Abstract
COVID-19 has many complications that affect many systems, including rheumatology and inflammatory skin conditions such as cutaneous lupus erythematosus. Herein, we describe the case of a patient with lupus panniculitis who presented with systemic lupus erythematosus in the setting of recent COVID-19 infection. A 66-year-old female patient presented to the hospital with expanded skin lesions all over her limbs, fever, joint pain, and fatigue. Lab tests and imaging revealed a second recent infection with COVID-19, positive titers of systemic lupus erythematosus antibodies, and biopsy confirmed lupus erythematosus panniculitis. She was treated with oral prednisone and hydroxychloroquine for SLE and symptomatic management for recent COVID-19 infection without ICU admission. Lupus erythematosus panniculitis (LEP) is a rare manifestation of lupus erythematosus. Although some cases of SLE following COVID-19 infection have been reported, lupus panniculitis as the initial presentation of systemic lupus erythematosus in these patients is extremely rare.
Highlights Lupus panniculitis (LP) as the initial presentation of Systemic Lupus Erythematosus is uncommon. SLE diagnosis can be difficult in patients with COVID-19 infection because both have some common characteristics. Erythema nodosum is an important differential diagnosis for lupus erythematosus panniculitis.
Applications of Synthetic Pentatricopeptide Repeat Proteins
Authors: Kwok van der Giezen Farley , Honkanen Suvi , Colas des Francs-Small Catherine , Bond Charles , Small Ian 
Published: November 2023

Abstract
RNA-binding proteins play integral roles in the regulation of essential processes in cells and as such are attractive targets for engineering to manipulate gene expression at the RNA level. Expression of transcripts in chloroplasts and mitochondria is heavily regulated by pentatricopeptide repeat (PPR) proteins. The diverse roles of PPR proteins and their naturally modular architecture make them ideal candidates for engineering. Synthetic PPR proteins are showing great potential to become valuable tools for controlling the expression of plastid and mitochondrial transcripts. In this review, by ‘synthetic’, we mean both rationally modified natural PPR proteins and completely novel proteins designed using the principles learned from their natural counterparts. We focus on the many different applications of synthetic PPR proteins, covering both their use in basic research to learn more about protein–RNA interactions and their use to achieve specific outcomes in RNA processing and the control of gene expression. We describe the challenges associated with the design, construction and deployment of synthetic PPR proteins and provide perspectives on how they might be assembled and used in future biotechnology applications.
The transcription factor MdBPC2 alters apple growth and promotes dwarfing by regulating auxin biosynthesis
Authors: Zhao Haiyan , Wan Shuyuan , Huang Yanni , Li Xiaoqiang , Jiao Tiantian , Zhang Zhijun , Ma Baiquan , Zhu Lingcheng , Ma Fengwang , Li Mingjun 
Published: November 2023

Abstract
Auxin plays important roles throughout plant growth and development. However, the mechanisms of auxin regulation of plant structure are poorly understood. In this study, we identified a transcription factor (TF) of the BARLEY B RECOMBINANT/BASIC PENTACYSTEINE (BBR/BPC) family in apple (Malus × domestica), MdBPC2. It was highly expressed in dwarfing rootstocks, and it negatively regulated auxin biosynthesis. Overexpression of MdBPC2 in apple decreased plant height, altered leaf morphology, and inhibited root system development. These phenotypes were due to reduced auxin levels and were restored reversed after exogenous indole acetic acid (IAA) treatment. Silencing of MdBPC2 alone had no obvious phenotypic effect, while silencing both Class I and Class II BPCs in apple significantly increased auxin content in plants. Biochemical analysis demonstrated that MdBPC2 directly bound to the GAGA-rich element in the promoters of the auxin synthesis genes MdYUC2a and MdYUC6b, inhibiting their transcription and reducing auxin accumulation in MdBPC2 overexpression lines. Further studies established that MdBPC2 interacted with the polycomb group (PcG) protein LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) to inhibit MdYUC2a and MdYUC6b expression via methylation of histone 3 lysine 27 (H3K27me3). Silencing MdLHP1 reversed the negative effect of MdBPC2 on auxin accumulation. Our results reveal a dwarfing mechanism in perennial woody plants involving control of auxin biosynthesis by a BPC transcription factor, suggesting its use for genetic improvement of apple rootstock.
How to Work with Muslim Clients in a Successful, Culturally Relevant Manner: A National Sample of American Muslims Share Their Perspectives
Authors: Hodge David R , Zidan Tarek , Husain Altaf 
Published: November 2023

Abstract
Despite the growing size of the American Muslim community, little research exists on the provision of culturally relevant services to members of this population. The purpose of this study was to identify American Muslims’ perceptions regarding what practitioners should know about Muslims and Islamic culture to provide successful mental health services to members of this community. To conduct this study, a purposive snowball sampling method was employed to obtain a national sample of community-dwelling American Muslims (N = 213). Qualitative analysis identified eight interlaced themes, which can be summarized as follows: (1) know basic Islamic beliefs, (2) recognize intragroup ethnic/cultural differences, (3) develop self-awareness of personal biases, (4) respect Islamic gender roles, (5) avoid making assumptions, (6) use Islamic beliefs/practices as strengths, (7) understand bias in the larger secular culture, and (8) consult with Muslim therapists/Imams. The findings equip practitioners with the information they need to provide effective, culturally relevant services to members of the unique American Muslim community from a posture of respect and cultural humility.
Credit instruments to alleviate global food insecurity: focus on crop receipts
Authors: Johnson Thomas 
Published: November 2023

Abstract
Global institutions have been looking for tools to alleviate food insecurity for years. COVID-19 and the conflict in Ukraine have exacerbated the situation, necessitating the mobilization of additional financial resources. This article focuses on financing instruments that can alleviate food insecurity by promoting financing in the pre-harvest phase, particularly crop receipts. Crop receipts recently attracted attention from international financial institutions, responding to inquiries from domestic policymakers about tools to increase access to credit for farmers. Crop receipts legislation has been enacted in Brazil, Ukraine, and Serbia, and several States are considering the enactment of such legislation. This article analyses the interaction of crop receipts with secured transactions and warehouse receipts legislation as well as regulatory frameworks applicable to banking, commodity exchanges, and capital markets. Guidance for those States contemplating enactment of crop receipts legislation is necessary to produce coherent secured transactions and warehouse receipts regimes and to forestall any approaches that might thwart their modernization along the lines of existing and emerging international standards. This article sheds light on the aspects of crop receipts finance for which guidance should be provided. It proposes that such guidance be included in the Agricultural Legal Financing Guide, which has been approved by the Governing Council of the International Institute for Unification of Private Law for the 2023–5 Work Programme.
Total Hip Arthroplasty in Teenagers: A Systematic Literature Review
Authors: te Velde Jens P. , Buijs George S. , Schafroth Matthias U. , Saouti Rachid , Kerkhoffs Gino M.M.J. , Kievit Arthur J. 
Published: November 2023

Background:
Total hip arthroplasty (THA) in teenagers is generally avoided. Nevertheless, recent THA procedures in a very young patient show improved functional outcomes and implant survival, resulting in lower revision rates. This review aims to present an overview of the available literature on THA in teenagers and to provide evidence to inform caregivers.

Methods:
In this systematic review, studies required a primary THA method and a teenage patient population. Studies must report at least one of the following outcome measures: functional outcomes, implant survival, and complications. In addition, demographic and surgical data were collected.

Results:
Sixteen studies were analyzed, including 2040 patients and 2379 hips, with an average 7.7-year follow-up. The mean patient age was 18 years, with an average revision rate of 11.7%. The overall average relative improvement of the 2 most frequently used patient-reported (functional) outcome measures were 84.3 and 92.3% at the latest follow-up. Prosthesis, or liner loosening, was the cause of revision in 50.2% of the cases. Loosening was the most frequent complication (14.8%), together with prosthesis/liner wear (14.8%). Cementless fixation (70.7%), ceramic-on-ceramic articulation (34.7%), and the posterior surgical approach (82.3%) were the most applied techniques.

Conclusions:
The functional outcomes after THA in teenagers improved at follow-up. The average revision rate is relatively high, especially in the pre-1995 studies, with post-1995 studies reporting similar revision rates to the adult patient group. Research to further improve implant survival as well as the ease of revisions in teenagers is needed.

Level of evidence:
Level III—systematic review.
Creatine Supplementation and Resistance Training in Patients With Breast Cancer (CaRTiC Study)
Authors: Martinez Aguirre-Betolaza Aitor , Cacicedo Jon , Castañeda-Babarro Arkaitz 
Published: November 2023

Background/Aims:
Creatine supplementation is an effective ergogenic nutrient for athletes, as well as for people starting a health or fitness program. Resistance training has previously been identified as an important method of increasing muscle mass and strength, especially in people with cancer to avoid sarcopenia. The potential of creatine supplementation for adaptations produced by resistance training in patients with cancer is still unknown. The primary aim of this study is to evaluate the effectiveness of a supervised resistance training program intervention with and without creatine supplementation in patients with breast cancer.

Methods:
Is a multicentre, randomized, blind, placebo-controlled study. Patients will be randomly assigned to a control group and 2 experimental groups. The first training resistance group (RG) will perform resistance training, while the second experimental resistance-creatine group will perform the same resistance training as the RG and will also receive a 5 g/d creatine supplementation during the intervention. RG participants will follow the same daily dosing protocol, but in their case, with dextrose/maltodextrin. Resistance training will be a 16-week supervised workout that will consist of a series of resistance exercises (leg press, knee extension, knee bends, chest press, sit-ups, back extensions, pull-ups, and shoulder press) that involve the largest muscle groups, performed 3 times a week on nonconsecutive days. Both the RG and the resistance-creatine group will receive a supplement of soluble protein powder (20 to 30 g) daily.

Conclusions:
This intervention will help to better understand the potential of nonpharmacological treatment for improving strength and well-being values in patients with breast cancer with and without creatine supplementation.
MRI of caval compression during left-lateral tilt in singleton and twin pregnancies
Authors: Fujita Nobuko , Higuchi Hideyuki , Yonekura Yuki 
Published: November 2023

BACKGROUND
It is unclear how different degrees of left-lateral tilt affect the volumes of the abdominal aorta and inferior vena cava (IVC) in pregnancy.

OBJECTIVE
To use magnetic resonance images to assess the volumes of the abdominal aorta and IVC in women with twin or singleton pregnancies in different degrees of left-lateral tilt.

DESIGN
Prospective cohort study.

SETTING
A single-centre university hospital.

PATIENTS
Women with singleton pregnancies (13) and twin pregnancies (13) at 32 to 38 weeks’ gestation.

MAIN OUTCOME MEASURES
Comparison of abdominal aortic and IVC volumes measured by MRI in women with singleton and twin pregnancies while in the supine or left-lateral tilt position at 15°, 30° and 45°.

RESULTS
Supine, the mean aortic and IVC volumes were not significantly different between the women with singleton and twin pregnancies. In a left-lateral tilt position of 15o compared with supine, the mean IVC volume was not increased in either group (singletons: 6.3 ± 6.6 ml, 95% CI, −2.4 to 0.4; P = 0.174; twins: 3.9 ± 2.4 ml, 95% CI, −2.6 to 0.4; P = 0.138). At tilt angles of 30° or 45°, the mean IVC volume significantly increased (singletons 30°: 9.7 ± 5.8 ml, 95% CI, −6.1 to −2.7; P < .001; singleton 45°:13.8 ± 5.0 ml, 95% CI, −11.3 to −5.7; P < .001; twins 30°: 5.7 ± 2.1 ml, 95% CI, −4.0 to −1.4; P < .001; twins 45°: 12.8 ± 9.4 ml, 95% CI, −17.2 to −2.6; P = 0.003). Aortic volume was not significantly increased in either group at any of the examined tilt angles compared with the supine.

CONCLUSION
IVC volume is significantly increased by 30° and 45° left-lateral tilt positions compared with supine in women with singleton and twin pregnancies.

TRIAL REGISTRATION
This study was registered in the University Hospital Medical Information Network (UMIN) clinical trial registration (# UMIN000031273).
Longitudinal analysis of microvascular changes in sickle cell disease using swept-source optical coherence tomography angiography
Authors: ENJALBERT Aurélie , GIOCANTI-AUREGAN Audrey , FAJNKUCHEN Franck , TORRES-VILLAROS Héloïse 
Published: November 2023

Purpose:
To analyze the changes in macular vascular densities (VD) and foveal avascular zone (FAZ) over a 6-year period using swept-source optical coherence tomography angiography (OCTA) in sickle cell patients compared to unaffected controls.

Methods:
Thirty eyes of sickle cell patients and 12 eyes of unaffected controls matched for age and ethnicity were examined at a 6-year interval using the same imaging protocol, including ultra-wide-field angiography, swept-source OCT and 3x3mm OCTA. The macular VD and FAZ were measured on ImageJ software according to previously reported algorithms.

Results:
In sickle cell eyes, the mean FAZ significantly increased (p <0.01), and the VD decreased in the foveal (within a circle of 1.5 mm in diameter around the foveal center) and temporal areas in both the superficial and deep capillary plexuses (p <0.01). The VD did not change over time in the parafoveal area (annulus between two circles of 1.5 and 3 mm in diameter) and in the superior, inferior, and nasal sectors. No worsening of peripheral retinopathy was observed in the cohort during the follow-up, except for one eye that developed sea-fan. In the control eyes, no microvascular change was observed over time in terms of FAZ size and VD.

Conclusion:
These longitudinal OCTA findings in sickle cell patients showed an enlargement of the FAZ and a decrease in VD in the temporal and perifoveal regions despite the absence of progression of peripheral retinopathy, suggesting a worsening of the macular non-perfusion over time in sickle cell disease.
Vision Correction Habits After COVID-19 Onset in Spectacle and Contact Lens Wearers
Authors: Rueff Erin M. , Chen Elaine Y. , Nguyen Andrew Loc 
Published: November 2023

Purpose:
To determine how vision correction habits changed after the 2019 coronavirus disease (COVID-19) pandemic onset.

Methods:
Participants reported vision correction habits, refractive error, screen time, mask wearing time, and dry eye symptoms since the COVID-19 pandemic onset through email survey.

Results:
A total of 133 participants completed the survey. Worsening dry eye symptoms were associated with increased screen time (P=0.04). Hours per day of spectacle wear increased by approximately 1 hr (P=0.001) and was associated with increased screen time (P=0.002). Worsening dry eye symptoms were associated with increased days per week of spectacle wear (P=0.02). Participants wore contact lenses about one day per week less than before the pandemic (P=0.0001). Increased mask wearing time was associated with increased days per week of contact lens wear (P=0.03).

Conclusions:
After pandemic onset, hours per day of spectacle wear increased, and days per week of contact lens wear decreased. Increases in hourly spectacle wear were associated with increased screen time, whereas increased daily contact lens wear was associated with increased mask wear time, suggesting that spectacles may be preferred for screen time activities and contact lenses for mask wear.
Validation of peritoneal neutrophil gelatinase-associated lipocalin as a biomarker for peritonitis: A comparison between laboratory-base method and rapid stick test
Authors: Morisi Niccolò , Virzì Grazia Maria , Barajas José David Gonzàlez , Diaz-Villavicencio Bladimir , Manani Sabrina Milan , Zanella Monica 
Published: November 2023

ABSTRACT

Background:
Neutrophil gelatinase-associated lipocalin (NGAL) is a multifunctional protein with roles beyond biomarker status, influencing critical processes. This study aimed to assess dipstick test for NGAL (NGALds), a novel dipstick test, against the established laboratory-based NGAL (NGALlab) method for early peritonitis detection, focusing on peritoneal fluid analysis to provide a rapid and cost-effective diagnostic tool for peritonitis management.

Methods:
Conducted at San Bortolo Hospital, Italy, this retrospective study collected samples from suspected or confirmed peritonitis cases between May 1, 2021, and December 31, 2021. Samples included peritoneal dialysate effluents (PDE) and underwent white blood cell counts, NGALds, NGALlab, and effluent culture.

Results:
The study analyzed 27 peritonitis cases, involving 133 PDE samples from 22 patients. NGALds exhibited a strong correlation (Rs = 0.732, P < 0.05) with NGALlab, particularly for medium to high-risk peritonitis cases, with a 98% accuracy rate.

Conclusion:
NGALds effectively aligns with NGALlab for peritonitis diagnosis, offering a valuable diagnostic tool, particularly suitable for point-of-care and resource-limited healthcare settings. Further research should investigate its correlation with neutrophil levels in PDE, solidifying NGALds as an accessible and efficient resource for peritonitis management.
The Effectiveness of Instruction on Lumbar Spine Thrust Joint Manipulation Task Performance
Authors: Manton Cory , Conley Quincy , Cleland Joshua A. , Puentedura Emilio J. 
Published: November 2023

Introduction.
Uncertainty exists regarding the best method for teaching thrust joint manipulation (TJM) to student physical therapists. The purpose of this study was to compare the effectiveness of Peyton's 4-step (P4) approach with the “see one, do one” (S1D1) approach for teaching students to perform a lumbar spine TJM task in an academic setting. Secondary objectives were to compare the effects of each instructional approach on students' attitudes and beliefs toward spinal TJM and on their motivation to learn to perform lumbar spine TJM.

Review of Literature.
The S1D1 approach is used in the health care professions for teaching clinical tasks to students. It is unclear whether the P4 approach may better prepare students to practice TJM.

Subjects.
Student physical therapists.

Methods.
Using a factorial quasi-experimental design, an equal number of students were assigned to a P4 or S1D1 instruction group for the TJM task. Students' performance accuracy, time, and outcome performing TJM in an academic setting were measured. Paper surveys were used to collect data about students' attitudes and beliefs toward spinal TJM and their motivation to learn TJM. A generalized estimating equations approach was used for data analysis.

Results.
Fifty-eight students (29 per group) completed the study. There was an interaction between the instruction group and time on task performance accuracy favoring the P4 approach (P = .03). There was no interaction between the instruction group and task performance time, task performance outcome, attitudes and beliefs toward spinal TJM, or motivation to learn TJM (all P > .19).

Discussion and Conclusion.
The P4 approach more effectively improved student accuracy when performing the TJM task in an academic setting than the S1D1 approach. However, no differences between instruction were found for performance time or outcome. Students reported a favorable perception of learning lumbar spine TJM. These preliminary results suggest that instructors may use the P4 approach to improve students' TJM procedural knowledge before task practice. However, limitations of the study may affect the internal validity and generalizability of results.
Representation of Racial Minorities in the United States Colonoscopy Surveillance Interval Guidelines
Authors: Zuberi Shaharyar A. , Burdine Lauren , Dong Jeffrey , Feuerstein Joseph D. 
Published: November 2023

Background/Aims:
Clinical guidelines should ideally be formulated from data representative of the population they are applicable to; however, historically, studies have disproportionally enrolled non-Hispanic White (NHW) patients, leading to potential inequities in care for minority groups. Our study aims to evaluate the extent to which racial minorities were represented in the United States Colorectal Cancer Surveillance Guidelines.

Methods:
We reviewed US guidelines between 1997 and 2020 and all identified studies cited by recommendations for surveillance after a baseline colonoscopy with no polyps, adenomas, sessile serrated polyps, and hyperplastic polyps. We analyzed the proportion of studies reporting race, and among these studies, we calculated the racial distribution of patients and compared the proportion of Non-NHW patients between each subtype.

Results:
For all guidelines, we reviewed 75 studies encompassing 9,309,955 patients. Race was reported in 24% of studies and 14% of total patients. Non-NHW comprised 43% of patients in studies for normal colonoscopies, compared with 9% for adenomas, 22% for sessile serrated polyps, and 15% for hyperplastic polyps. For the 2020 guidelines, we reviewed 33 studies encompassing 5,930,722 patients. Race was reported in 15% of studies and 21% of total patients. Non-NHW comprised 43% of patients in studies for normal colonoscopies, compared with 9% for tubular adenomas. Race was not cited for any other 2020 guideline.

Conclusion:
Racial minorities are significantly underrepresented in US Colorectal Cancer Surveillance Guidelines, which may contribute to disparities in care. Future studies should prioritize enrolling a diverse patient population to provide data that accurately reflects their population.