bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Jurassic Tethyan igneous records in North Sumatra: Geochronological and geochemical constraints
Authors: Xu Chang , Wang Yuejun , Qian Xin , Yu Xiaoqing , Murtadha Sayed 
Published: January 2024

Abstract
The Jurassic igneous rocks on Sumatra Island are important for investigating the Mesotethyan evolution and regional correlation in Southeast Asia. This paper presents new laser ablation–multicollector–inductively coupled plasma–mass spectrometry zircon U-Pb-Hf geochronological and isotopic, whole-rock elemental, and Sr-Nd isotopic data for the newly identified Glebruk dolerite and andesite in North Sumatra. New zircon dating results suggest that these mafic–intermediate volcanic rocks, with ages of 150–146 Ma, were formed during the Late Jurassic. The Glebruk dolerite and andesite belong to the calc-alkaline series, are enriched in the light rare earth elements, and exhibit depletion in Nb, Ta, and Ti. Thus, they resemble arc-like volcanic rocks. They have low (87Sr/86Sr)i ratios of 0.7038–0.7048 and strong positive εNd(t) and εHf(t) values of +6.4 to +7.5 and +4.8 to +18.6, respectively. Their geochemical signatures suggest that these Late Jurassic volcanic rocks were derived from a depleted mantle wedge that was metasomatized by the slab-derived melts. The Glebruk volcanic rocks were formed in a continental arc setting in response to the Late Jurassic northward subduction of the Woyla Ocean beneath West Sumatra. Our results and regional geological observations suggest that the Mesotethyan subduction-related igneous rocks could extend from South Qiangtang through West Yunnan to North Sumatra. The Woyla Ocean could represent the southern extension of the Mesotethyan Ocean.
Efficacy of acupuncture for whiplash injury: a systematic review and meta-analysis
Authors: Lee Sang-Hyun , Park Sun-Young , Heo In , Hwang Eui-Hyoung , Shin Byung-Cheul , Hwang Man-Suk 
Published: January 2024

ObjectivesThis study aimed to establish clinical evidence for acupuncture by analysing data from trials that demonstrated the efficacy of acupuncture for whiplash-associated disorder (WAD) with the following research question: Is acupuncture treatment effective for symptom alleviation in patients with WAD compared with other usual care?DesignA systematic review and meta-analysis.Data sourcesPubMed, Ovid Medline, Embase, The Cochrane Library, China National Knowledge Infrastructure, ScienceOn, KMBASE, Korean Studies Information Service System, Korea Med, Oriental Medicine Advanced Searching Integrated System and Research Information Sharing Service were searched from their inception to 1 October 2023.Eligibility criteriaWe included randomised controlled trials (RCTs) using acupuncture on patients with WAD. The outcomes were the pain visual analogue scale (VAS) score or numerical rating scale score for neck pain, the range of motion (ROM) of the neck, the Neck Disability Index and safety.Data extraction and synthesisTwo independent researchers analysed and extracted data from the selected literatures. The risk of bias and the quality of evidence were assessed according to the Cochrane Handbook for Systematic Reviews of Interventions and the Grading of Recommendations Assessment, Development, and Evaluation method, respectively.ResultsA total of 525 patients with WAD from eight RCTs were included in this study. The meta-analysis revealed that the outcomes showed significant differences in the pain VAS score (standard mean difference (SMD): −0.57 (–0.86 to –0.28), p<0.001) and ROM-extension (SMD: 0.47 (0.05 to 0.89), p=0.03). The risk of bias assessment revealed that four studies published after 2012 (50%, 4 out of 8 studies) showed low bias in most domains. The pain VAS score was graded as having moderate certainty.ConclusionAcupuncture may have clinical value in pain reduction and increasing the ROM for patients with WAD. High-quality RCTs must be conducted to confirm the efficacy of acupuncture in patients with WAD.Trial registration numberPROSPERO CRD42021261595.
Status and treatment of patients with uterine fibroids in hospitals in central China: a retrospective study from 2018 to 2021
Authors: Yan Wei , Yuan Suzhen , Zhou Da , Zhang Minli , Yang Shuhao , Wang Wenwen , Wang Shixuan 
Published: January 2024

ObjectiveTo evaluate the hospitalised patients with uterine fibroids (UFs) and describe treatment patterns in hospital-treated patients in central China from 2018 to 2021.DesignA retrospective analysis.SettingThe gynaecology departments of class A and class B secondary and tertiary hospitals in Hubei Province, China.Participants101 008 patients diagnosed with UFs from 1 January 2018 to 31 December 2021.ResultsThe hospitalised patients with UFs increased with age, reaching a peak at ages 45–49 years and then gradually decreasing. Among these patients, 19.05% had anaemia symptoms. Women aged 25–29 years were more likely to be treated with laparoscopic myomectomy (62.22%), while women aged 20–24 years tend to choose open myomectomy (34.58%). Women over age 45 years who had entered perimenopause tended to be treated with laparoscopic hysterectomy (64.85% for those aged 65–69 years). Patients with fibroid with moderate-to-severe anaemia mostly chose hysterectomy. As a whole, the proportion of patients who chose laparoscopic hysterectomy was similar to that of patients who chose laparoscopic myomectomy (31.38% vs 31.14%). Only 2.08% of UFs were treated with high-frequency MRI-guided focused ultrasound surgery (MRgFUS). The number of patients who choose laparoscopic surgery or MRgFUS treatment was increasing year by year. After stratifying by hospital grade, we found that women treated at class A tertiary hospitals were more likely to have laparoscopic than open surgery (66.12% vs 31.26%). At class B secondary hospitals, 61.9% of the patients underwent myomectomy. By contrast, hysterectomy was used to treat the majority of patients at class A secondary hospitals and class B tertiary hospitals (57.79% and 57.57%, respectively). Use of MRgFUS was mainly concentrated within class A tertiary hospitals.ConclusionUFs affect mainly women in childbearing period. Most patients chose to receive treatment at class A tertiary hospitals, among which laparoscopic myomectomy was the mainstream surgical method for patients in Hubei Province.Trial registration numberNCT05840042.
Fibrosis in IBD: from pathogenesis to therapeutic targets
Authors: Rieder Florian , Mukherjee Pranab K , Massey William J , Wang Yan , Fiocchi Claudio 
Published: January 2024

BackgroundIntestinal fibrosis resulting in stricture formation and obstruction in Crohn’s disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest unmet needs in inflammatory bowel disease (IBD). Fibrosis is caused by a multifactorial and complex process involving immune and non-immune cells, their soluble mediators and exposure to luminal contents, such as microbiota and environmental factors. To date, no antifibrotic therapy is available. Some progress has been made in creating consensus definitions and measurements to quantify stricture morphology for clinical practice and trials, but approaches to determine the degree of fibrosis within a stricture are still lacking.ObjectiveWe herein describe the current state of stricture pathogenesis, measuring tools and clinical trial endpoints development.DesignData presented and discussed in this review derive from the past and recent literature and the authors’ own research and experience.Results and conclusionsSignificant progress has been made in better understanding the pathogenesis of fibrosis, but additional studies and preclinical developments are needed to define specific therapeutic targets.
Contribution of causes of death to changing inequalities in life expectancy by income in Finland, 1997–2020
Authors: Tarkiainen Lasse , Martikainen Pekka , Junna Liina , Remes Hanna 
Published: January 2024

BackgroundSocioeconomic inequalities in mortality originate from different causes of death. Alcohol-related and smoking-related deaths are major drivers of mortality inequalities across Europe. In Finland, the turn from widening to narrowing mortality disparities by income in the early 2010s was largely attributable to these causes of death. However, little is known about recent inequalities in life expectancy (LE) and lifespan variation.MethodsWe used individual-level total population register-based data with annual information on disposable household income and cause-specific mortality for ages 30–95+, and assessed the contribution of smoking on mortality using the Preston-Glei-Wilmoth method. We calculated trends in LE at age 30 and SD in lifespan by income quintile in 1997–2020 and conducted age and cause-of-death decompositions of changes in LE.ResultsDisparity in LE and lifespan variation by income increased in 2015–2020, largely attributable to the stagnation of both measures in the lowest income quintile. The LE gap between the extreme quintiles in 2018–2020 was 11.2 (men) and 5.9 (women) years, of which roughly 40% was attributable to alcohol and smoking. However, the recent widening of the gap and the stagnation in LE in the lowest quintile over time were not driven by any specific cause-of-death group.ConclusionsAfter a decade of narrowing inequalities in LE and lifespan variation in Finland, the gaps between income groups are growing again. Increasing LE disparity and stagnating mortality on the lowest income levels are no longer attributable to smoking and alcohol-related deaths but are more comprehensive, originating from most cause-of-death groups.
Therapeutic drug monitoring of mycophenolic acid and clinical outcomes of lupus nephritis: a systematic review and meta-analysis
Authors: Wuttiputhanun Thunyatorn , Naiyarakseree Nuanjanthip , Udomkarnjananun Suwasin , Kittanamongkolchai Wonngarm , Asada Leelahavanichkul , Chariyavilaskul Pajaree , Townamchai Natavudh , Avihingsanon Yingyos 
Published: January 2024

IntroductionMycophenolic acid (MPA) is a primary immunosuppressive agent used in the treatment of lupus nephritis (LN). While therapeutic drug monitoring (TDM) of MPA is well established in organ transplantation, its role in LN treatment remains uncertain. Our objective was to review and summarise current knowledge on TDM of MPA in the LN treatment.MethodsA systematic search was conducted in the online databases, specifically targeted patients diagnosed with LN receiving MPA treatment. The included studies had to report both MPA pharmacokinetic parameters and renal outcomes. A random-effects model meta-analysis was conducted to assess the relationship between clinical responses and MPA pharmacokinetics.ResultsA total of 1507 studies were initially screened, resulting in the inclusion of 16 studies for meta-analysis, encompassing 433 patients. The response group exhibited significantly higher MPA area under the concentration-time curve (AUC) compared with the non-response group (51.44±21.73 mg·h/L vs 30.30±16.24 mg·h/L). The weighted mean difference (WMD) of MPA-AUC between responders and non-responders was 16.83 mg·h/L (95% CI 10.59 to 23.06; p<0.001). Similarly, trough concentration (C0) of MPA showed a strong association with renal response, evidenced by C0values of 2.50±1.73 mg/L in the response group vs 1.51±1.33 mg/L in the non-response group (WMD 1.37 mg/L; 95% CI 0.77 to 1.97; p<0.001). There was no significant relationship identified between MPA-AUC and adverse events.ConclusionThis meta-analysis emphasised the meaningful correlation between MPA AUC and C0with renal response in LN treatment. Randomised controlled trials are necessary to validate this approach and determine its superiority over fixed dosing in the context of LN treatment.
Association of firefighting exposures with lung function using a novel job exposure matrix (JEM)
Authors: Goldfarb David G , Prezant David J , Zeig-Owens Rachel , Hall Charles B , Schwartz Theresa , Liu Yang , Kavouras Ilias G 
Published: January 2024

ObjectivesCharacterisation of firefighters’ exposures to dangerous chemicals in smoke from non-wildfire incidents, directly through personal monitoring and indirectly from work-related records, is scarce. The aim of this study was to evaluate the association between smoke particle exposures (P) and pulmonary function.MethodsThe study period spanned from January 2010 through September 2021. Routine firefighting P were estimated using fire incident characteristics, response data and emission factors from a novel job exposure matrix. Linear mixed effects modelling was employed to estimate changes in pulmonary function as measured by forced expiratory volume in one second (FEV1). Models controlled for age, race/ethnicity, height, smoking and weight.ResultsEvery 1000 kg P was associated with 13 mL lower FEV1(β=−13.34; 95% CI=−13.98 to −12.70) over the entire 12-year follow-up period. When analysing exposures within 3 months before PFT measurements, 1000 kg P was associated with 27 mL lower FEV1(β=−26.87; 95% CI=−34.54 to −19.20). When evaluating P estimated within 3 months of a pulmonary function test (PFT), stronger associations were observed among those most highly exposed to the World Trade Center (WTC) disaster (β=−12.90; 95% CI=−22.70 to −2.89); the association of cumulative exposures was similar for both highly and less highly exposed individuals.DiscussionSmoke particle exposures were observed to have modest short-term and long-term associations with pulmonary function, particularly in those who, previously, had high levels of WTC exposure. Future work examining the association between P and pulmonary function among non-WTC exposed firefighters will be essential for disentangling the effects of ageing, routine firefighting and WTC exposures.
Reissner–Nordström black holes in quintic quasi-topological gravity
Authors: Olamaei A. R. , Bazrafshan A. , Ghanaatian M. 
Published: January 2024

AbstractThis paper investigates charged black holes within the framework of quintic quasi-topological gravity, focusing on their thermodynamics, conserved quantities, and stability. We construct numerical solutions and explore their thermodynamic properties, supplemented by the study of analytically solvable special cases. By verifying the first law of thermodynamics, we validate our approach and compare our findings to those of Einstein gravity. The physical properties of the solutions are examined across anti-de Sitter, de Sitter, and flat spacetime backgrounds. Our analysis reveals that anti-de Sitter solutions demonstrate thermal stability, while de Sitter and flat solutions lack this property. Finally, we discuss the implications of our results and propose potential avenues for future research in this field.
Quantumness near a Schwarzschild black hole
Authors: Haddadi S. , Yurischev M. A. , Abd-Rabbou M. Y. , Azizi M. , Pourkarimi M. R. , Ghominejad M. 
Published: January 2024

AbstractThe merging of quantum information science with the relativity theory presents novel opportunities for understanding the enigmas surrounding the transmission of information in relation to black holes. For this purpose, we study the quantumness near a Schwarzschild black hole in a practical model under decoherence. The scenario we consider in this paper is that a stationary particle in the flat region interacts with its surroundings while another particle experiences free fall in the vicinity of a Schwarzschild black hole’s event horizon. We explore the impacts of Hawking radiation and decoherence on the system under investigation and find that these effects can limit the survival of quantum characteristics, but cannot destroy them completely. Hence, the results of this study possess the potential to yield valuable insights into the comprehension of the quantum properties of a real system operating within a curved space-time framework.
Dimensionally continued black holes sourced by a conformally coupled scalar field and Chaplygin-like dark fluid
Authors: Ali Askar , Saifullah Khalid 
Published: January 2024

AbstractIn this paper, we study the higher dimensional black holes of Lovelock gravity coupled with a conformal scalar field. The matter source of gravity is suggested to come from the Chaplygin-like dark fluid, i.e., the hybrid of a dark matter and dark energy. We primarily focus on dimensionally continued gravity where the coupling parameters are reduced into two independent parameters, i.e., the Newtonian and cosmological constants. In this specific case of Lovelock gravity, we derive the metric function that describes the hairy black holes surrounded by dark fluid. For these objects, the basic thermodynamic quantities are worked out. We discuss how the unified dark fluid affects both local and global thermodynamic stabilities. We also demonstrate that the radiation spectrum is proportional to the change in entropy of the hairy black holes. Lastly, the hairy black holes in the presence of Chaplygin-like dark fluid are briefly investigated within the context of generic Lovelock gravity.
Axion-like particles at future $$e^- p$$ collider
Authors: Mosala Karabo , Sharma Pramod , Kumar Mukesh , Goyal Ashok 
Published: January 2024

AbstractIn this work, we explore the possibilities of producing Axion-Like Particles (ALPs) in a future$$e^-p$$e-pcollider. Specifically, we focus on the proposed Large Hadron electron collider (LHeC), which can achieve a center-of-mass energy of$$\sqrt{s} \approx 1.3$$s≈1.3 TeV, enabling us to probe relatively high ALP masses with$$m_a \lesssim 300$$ma≲300 GeV. The production of ALPs can occur through various channels, including$$W^+W^-$$W+W-,$$\gamma \gamma $$γγ,ZZ, and$$Z\gamma $$Zγ-fusion within the collider environment. To investigate this, we conduct a comprehensive analysis that involves estimating the production cross section and constraining the limits on the associated couplings of ALPs, namely$$g_{WW}$$gWW,$$g_{\gamma \gamma }$$gγγ,$$g_{ZZ}$$gZZ, and$$g_{Z\gamma }$$gZγ. To achieve this, we utilize a multiple-bin$$\chi ^2$$χ2analysis on sensitive differential distributions. Through the analysis of these distributions, we determine upper bounds on the associated couplings within the mass range of 5 GeV$$\le m_a \le $$≤ma≤300 GeV. The obtained upper bounds are of the order of$$\mathcal{O}(10^{-1})$$O(10-1)for$$g_{\gamma \gamma }$$gγγ($$g_{WW}$$gWW,$$g_{ZZ}$$gZZ,$$g_{Z\gamma }$$gZγ) in$$m_a \in $$ma∈ [5, 200 (300)] GeV considering an integrated luminosity of 1 ab$$^{-1}$$-1. Furthermore, we compare the results of our study with those obtained from other available experiments. We emphasize the limits obtained through our analysis and showcase the potential of the LHeC in probing the properties of ALPs.
Reentrant phase transition in holographic thermodynamicsof Born–Infeld AdS black hole
Authors: Bai Ning-Chen , Song Li , Tao Jun 
Published: January 2024

AbstractIn this paper, we study the phase tranisions in the extended holographic thermodynamics of Born–Infeld AdS black holes. The extended gravitational thermodynamics of black holes is related to the thermodynamics of the dual field theory by varying both cosmological constant and Newton’s constant. With topological analysis and numerical calculation, we find that the reentrant large-small-large black hole phase transition still exists in $$D=4$$

D
=
4

. Interestingly, a similar reentrant phase transition is also observed in the dual field theory, between the high-, low- and high-entropy thermal states. For higher dimension $$D>4$$

D
>
4

, only the van der Waals like phase transition is observed, both in the bulk and the dual field theory.
On the Use of Quality Diversity Algorithms for the Travelling Thief Problem
Authors: Nikfarjam Adel , Neumann Aneta , Neumann Frank 
Published: January 2024

In real-world optimisation, it is common to face several sub-problems interacting and forming the main problem. There is an inter-dependency between the sub-problems, making it impossible to solve such a problem by focusing on only one component. The travelling thief problem (TTP) belongs to this category and is formed by the integration of the travelling salesperson problem (TSP) and the knapsack problem (KP). In this paper, we investigate the inter-dependency of the TSP and the KP by means of quality diversity (QD) approaches. QD algorithms provide a powerful tool not only to obtain high-quality solutions but also to illustrate the distribution of high-performing solutions in the behavioural space.
We introduce a multi-dimensional archive of phenotypic elites (MAP-Elites) based evolutionary algorithm using well-known TSP and KP search operators, taking the TSP and KP score as the behavioural descriptor. MAP-Elites algorithms are QD-based techniques to explore high-performing solutions in a behavioural space. Afterwards, we conduct comprehensive experimental studies that show the usefulness of using the QD approach applied to the TTP. First, we provide insights regarding high-quality TTP solutions in the TSP/KP behavioural space. Afterwards, we show that better solutions for the TTP can be obtained by using our QD approach, and it can improve the best-known solution for a number of TTP instances used for benchmarking in the literature.
Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Authors: Dunbar Andrew J. , Bowman Robert L. , Park Young C. , O'Connor Kavi , Izzo Franco , Myers Robert M. , Karzai Abdul , Zaroogian Zachary , Kim Won Jun , Fernández-Maestre Inés , Waarts Michael R. , Nazir Abbas , Xiao Wenbin , Codilupi Tamara , Brodsky Max , Farina Mirko , Cai Louise , Cai Sheng F. , Wang Benjamin , An Wenbin , Yang Julie L. , Mowla Shoron , Eisman Shira E. , Hanasoge Somasundara Amritha Varshini , Glass Jacob L. , Mishra Tanmay , Houston Remie , Guzzardi Emily , Martinez Benitez Anthony R. , Viny Aaron D. , Koche Richard P. , Meyer Sara C. , Landau Dan A. , Levine Ross L. 
Published: January 2024

Abstract

Gain-of-function mutations activating JAK/STAT signaling are seen in the majority of patients with myeloproliferative neoplasms (MPN), most commonly JAK2V617F. Although clinically approved JAK inhibitors improve symptoms and outcomes in MPNs, remissions are rare, and mutant allele burden does not substantively change with chronic therapy. We hypothesized this is due to limitations of current JAK inhibitors to potently and specifically abrogate mutant JAK2 signaling. We therefore developed a conditionally inducible mouse model allowing for sequential activation, and then inactivation, of Jak2V617F from its endogenous locus using a combined Dre-rox/Cre-lox dual-recombinase system. Jak2V617F deletion abrogates MPN features, induces depletion of mutant-specific hematopoietic stem/progenitor cells, and extends overall survival to an extent not observed with pharmacologic JAK inhibition, including when cooccurring with somatic Tet2 loss. Our data suggest JAK2V617F represents the best therapeutic target in MPNs and demonstrate the therapeutic relevance of a dual-recombinase system to assess mutant-specific oncogenic dependencies in vivo.

Significance:
Current JAK inhibitors to treat myeloproliferative neoplasms are ineffective at eradicating mutant cells. We developed an endogenously expressed Jak2V617F dual-recombinase knock-in/knock-out model to investigate Jak2V617F oncogenic reversion in vivo. Jak2V617F deletion abrogates MPN features and depletes disease-sustaining MPN stem cells, suggesting improved Jak2V617F targeting offers the potential for greater therapeutic efficacy.
See related commentary by Celik and Challen, p. 701.
This article is featured in Selected Articles from This Issue, p. 695