bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bionic Blade Lift‐Drag Combination Triboelectric‐Electromagnetic Hybrid Generator with Enhanced Aerodynamic Performance for Wind Energy Harvesting
Authors: Zhu Mingkang , Yu Yang , Zhu Jianyang , Zhang Jiacheng , Gao Qi , Li Hengyu , Zhang Yuejun , Wang Zhong Lin , Cheng Tinghai 
Published: October 2023

AbstractThe triboelectric nanogenerator (TENG) is a promising technology with unique advantages for harvesting environmental high‐entropy energy like wind power. However, inefficient wind energy harvest devices have limited the operating wind speed and practical application of TENGs. In this work, a bionic blade lift‐drag hybrid turbine‐driven triboelectric‐electromagnetic hybrid generator (HT‐TEHG) is designed for broadband wind energy harvesting. The lift‐drag hybrid turbine combines the benefits of drag‐type blades enabling low wind speed start‐up and bionic lift‐type blades generating high torque, achieving an 11% increase in performance. The TENGs are designed with appropriate dielectric layer gaps to balance the output performance and friction torque and are independently driven by two types of blades to achieve self‐adaptive graded power generation at different wind speeds. The starting wind speed of the HT‐TEHG is 2 m s−1 and achieves a peak power of 202.4 mW with an energy conversion efficiency of 9.1% at a wind speed of 4 m s−1. The durability of the TENG is verified by continuous operation for 1 × 105 cycles with almost no performance degradation. Moreover, the HT‐TEHG can power a wireless weather station using natural wind. The study introduces a valuable approach to harvest broadband wind energy and enable distributed power for Internet of Things devices.
Computational fluid dynamics modeling and mass transfer study of an in situ gas production process
Authors: Wei Hui‐Long , Su Yuanhai , Pan De‐Tao , Luo Zheng‐Hong 
Published: October 2023

AbstractThe oxidation of cyclohexanone with nitric acid in microreactors, as a representative chemical reaction with in situ gas production, was selected as the model reaction for computational fluid dynamics (CFD) modeling. The reaction kinetics was coupled with the CFD model by user‐defined functions (UDFs) to obtain the velocity field of liquid phase, the concentration field of products, and the temperature field of gas–liquid phases during the reaction process. The simulation results were then validated by the experimental data. Based on the established model, the fluid flow behavior and mass transfer characteristics during the in situ gas production process in a microreactor were further analyzed. Finally, the effects of channel diameter and bubble velocity on gas–liquid interfacial mass transfer were investigated. This work provides an effective method for studying in situ gas production processes through modeling and simulation, which is valuable in the design and optimization of tubular reactors.
Systematic exploration of a decade of publications on psychiatric genetics in Latin America
Authors: Garro‐Núñez Diana , Picado‐Martínez María Jesús , Espinoza‐Campos Erika , Ugalde‐Araya Daniela , Macaya Gabriel , Raventós Henriette , Chavarría‐Soley Gabriela 
Published: October 2023

AbstractPsychiatric disorders have a great impact in terms of mortality, morbidity, and disability across the lifespan. Considerable effort has been devoted to understanding their complex and heterogeneous genetic architecture, including diverse ancestry populations. Our aim was to review the psychiatric genetics research published with Latin American populations from 2010 to 2019, and classify it according to country of origin, type of analysis, source of funding, and other variables. We found that most publications came from Brazil, Mexico, and Colombia. Also, local funds are generally not large enough for genome‐wide studies in Latin America, with the exception of Brazil and Mexico; larger studies are often done in collaboration with international partners, mostly funded by US agencies. In most of the larger studies, the participants are individuals of Latin American ancestry living in the United States, which limits the potential for exploring the complex gene–environment interaction. Family studies, traditionally strong in Latin America, represent about 30% of the total research publications. Scarce local resources for research in Latin America have probably been an important limitation for conducting bigger and more complex studies, contributing to the reduced representation of these populations in global psychiatric genetics studies. Increasing diversity must be a goal to improve generalizability and applicability in clinical settings.
William Boven's 1915 thesis “Similarity and Mendelism in the heredity of dementia praecox and manic‐depressive insanity”
Authors: Kendler Kenneth S. , Justis Virginia 
Published: October 2023

AbstractBoven published, in 1915, his MD thesis at the University of Lausanne in which he examined 60 3‐ to 4‐generation pedigrees ascertained from admitted patients with dementia praecox (DP) and manic‐depressive insanity (MDI). He asked three questions: (i) were DP and MDI hereditary? (ii) were they the same or distinct conditions? and (iii) were they Mendelian disorders? Based on the rarity of environmental precipitants severe enough to cause disorder onset and the pattern of disorders in relatives, Boven concluded that both disorders were inherited. He found that MDI largely ran in families through direct transmission across generations while DP was only common in collateral relatives. Both pedigrees contained a substantial number of “psychopathic” (personality disordered) relatives in which DP and MDI pedigrees typically had, respectively, paranoid, and dysthymic/cyclothymic features. Boven concludes that their inheritance is largely distinct but not exclusive, as some pedigrees contained cases of both disorders. With assistance from Wilhelm Weinberg, Boven applied algebraic models with proband correction to rates of DP and MDI in sibships and found the results inconsistent with Mendelian transmission. His study represents among the first examinations, using “modern” methods, of the familial relationship between DP and MDI and the first published in French.
A cadaveric breast cancer tissue phantom for phase‐contrast X‐ray imaging applications
Authors: Rounds Cody C. , Li Chengyue , Zhou Wei , Tichauer Kenneth M. , Brankov Jovan G. 
Published: October 2023

AbstractBackgroundAs mammography X‐ray imaging technologies advance and provide elevated contrast in soft tissues, a need has developed for reliable imaging phantoms for use in system design and component calibration. In advanced imaging modalities such as refraction‐based methods, it is critical that developed phantoms capture the biological details seen in clinical precancerous and cancerous cases while minimizing artifacts that may be caused due to phantom production. This work presents the fabrication of a breast tissue imaging phantom from cadaveric breast tissue suitable for use in both transmission and refraction‐enhanced imaging systems.MethodsHuman cancer cell tumors were grown orthotopically in nude athymic mice and implanted into the fixed tissue while maintaining the native tumor/adipose tissue interface.ResultsThe resulting human–murine tissue hybrid phantom was mounted on a clear acrylic housing for absorption and refraction X‐ray imaging. Digital breast tomosynthesis was also performed.ConclusionBoth attenuation‐based imaging and refraction‐based imaging of the phantom are presented to confirm the suitability of this phantom's use in both imaging modalities.
Substrate‐Mediator Duality of 1,4‐Dicyanobenzene in Electrochemical C(sp2)−C(sp3) Bond Formation with Alkyl Bromides
Authors: Johnston Brandon , Loh Daniel M. , Nocera Daniel G. 
Published: October 2023

AbstractElectrochemical approaches to form C(sp2)−C(sp3) bonds have focused on coupling C(sp3) electrophiles that form stabilized carbon‐centered radicals upon reduction or oxidation. Whereas alkyl bromides are desirable C(sp3) coupling partners owing to their availability and cost‐effectiveness, their tendency to undergo radical‐radical homocoupling makes them challenging substrates for electroreductive cross‐coupling. Herein, we disclose a metal‐free regioselective cross‐coupling of 1,4‐dicyanobenzene, a useful precursor to aromatic nitriles, and alkyl bromides. Alkyl bromide reduction is mediated directly by 1,4‐dicyanobenzene radical anions, leading to negligible homocoupling and high cross‐selectivity to form 1,4‐alkyl cyanobenzenes. The cross‐coupling scheme is compatible with oxidatively sensitive and acidic functional groups such as amines and alcohols, which have proven difficult to incorporate in alternative electrochemical approaches using carboxylic acids as C(sp3) precursors.
The Construction of Highly Substituted Piperidines via Dearomative Functionalization Reaction
Authors: Hu Miao , Ding Hao , DeSnoo William , Tantillo Dean J. , Nairoukh Zackaria 
Published: October 2023

AbstractNitrogen heterocycles play a vital role in pharmaceuticals and natural products, with the six‐membered aromatic and aliphatic architectures being commonly used. While synthetic methods for aromatic N‐heterocycles are well‐established, the synthesis of their aliphatic functionalized analogues, particularly piperidine derivatives, poses a significant challenge. In that regard, we propose a stepwise dearomative functionalization reaction for the construction of highly decorated piperidine derivatives with diverse functional handles. We also discuss challenges related to site‐selectivity, regio‐ and diastereoselectivity, and provide insights into the reaction mechanism through mechanistic studies and density functional theory computations.
Co−Co Dinuclear Active Sites Dispersed on Zirconium‐doped Heterostructured Co9S8/Co3O4 for High‐current‐density and Durable Acidic Oxygen Evolution
Authors: Wang Ligang , Su Hui , Zhang Zhuang , Xin Junjie , Liu Hai , Wang Xiaoge , Yang Chenyu , Liang Xiao , Wang Shunwu , Liu Huan , Yin Yanfei , Zhang Taiyan , Tian Yang , Li Yaping , Liu Qinghua , Sun Xiaoming , Sun Junliang , Wang Dingsheng , Li Yadong 
Published: October 2023

AbstractDeveloping cost‐effective and sustainable acidic water oxidation catalysts requires significant advances in material design and in‐depth mechanism understanding for proton exchange membrane water electrolysis. Herein, we developed a single atom regulatory strategy to construct Co−Co dinuclear active sites (DASs) catalysts that atomically dispersed zirconium doped Co9S8/Co3O4 heterostructure. The X‐ray absorption fine structure elucidated the incorporation of Zr greatly facilitated the generation of Co−Co DASs layer with stretching of cobalt oxygen bond and S−Co−O heterogeneous grain boundaries interfaces, engineering attractive activity of significantly reduced overpotential of 75 mV at 10 mA cm−2, a breakthrough of 500 mA cm−2 high current density, and water splitting stability of 500 hours in acid, making it one of the best‐performing acid‐stable OER non‐noble metal materials. The optimized catalyst with interatomic Co−Co distance (ca. 2.80 Å) followed oxo‐oxo coupling mechanism that involved obvious oxygen bridges on dinuclear Co sites (1,090 cm−1), confirmed by in situ SR‐FTIR, XAFS and theoretical simulations. Furthermore, a major breakthrough of 120,000 mA g−1 high mass current density using the first reported noble metal‐free cobalt anode catalyst of Co−Co DASs/ZCC in PEM‐WE at 2.14 V was recorded.
Single‐Crystal‐to‐Single‐Crystal Topochemical Synthesis of a Collagen‐inspired Covalent Helical Polymer
Authors: Rai Rishika , Khazeber Ravichandran , Sureshan Kana M 
Published: October 2023

AbstractThere is much demand for crystalline covalent helical polymers. Inspired by the helical structure of collagen, we synthesized a covalent helical polymer wherein the repeating dipeptide Gly‐Pro units are connected by triazole linkages. We synthesized an azide and alkyne‐modified dipeptide monomer made up of the repeating amino acid sequence of collagen. In its crystals, the monomer molecules aligned in head‐to‐tail fashion with proximally placed azide and alkyne forming supramolecular helices. At 60 °C, the monomer underwent single‐crystal‐to‐single‐crystal (SCSC) topochemical azide‐alkyne cycloaddition polymerization, yielding a covalent helical polymer as confirmed by single‐crystal X‐ray diffraction (SCXRD) analysis. Compared to the monomer crystals, the polymer single‐crystals were very strong and showed three‐fold increase in Young's modulus, which is higher than collagen, many synthetic polymers and other materials. The crystals of this covalent helical polymer could bear loads as high as 1.5 million times of their own weight without deformation. These crystals could also withstand high compression force and did not disintegrate even at an applied force of 98 kN. Such light‐weight strong materials are in demand for various technological applications.
Box–Behnken response surface method for the synthesis of high‐temperature‐ and salt‐resistant filter loss reducers
Authors: Yang Fan , Li Da‐Qi , Song Yong‐Tao , Zhang Ying , Shu Wen‐Ming , Yu Wei‐Chu 
Published: October 2023

AbstractWellbores are destabilized by the immersion of a formation in drilling fluid during deep well drilling. To address this issue, in the present study, trimethylolethane triallyl ether (TMETE), 2‐acrylamide‐2‐methylpropanesulfonic acid (AMPS), acrylamide, and N‐vinylpyrrolidone undergo free radical copolymerization to produce a PTAAN filter loss reducer. The Box–Behnken response surface method is used to optimize the synthesis of PTAAN; the optimal conditions are 1 wt% TMETE and 0.1111 wt% initiator at 60°C. Fourier transform infrared spectroscopy, transmission electron microscopy, and thermogravimetric analysis are used to characterize the composition, micromorphology, and thermal stability of the PTAAN product, respectively. The synthesized product is resistant to high temperatures and salt under the optimal synthesis conditions. It has an API filtration loss of 8.2 mL for freshwater‐based mud, an API filtration loss of 13.8 mL for 20% by weight brine mud after aging at 220°C, and an API filtration loss of 29.5 mL at 150°C under high temperatures and pressures. Incorporating PTAAN into the base slurry prevents clay particle agglomeration at elevated temperatures and high mineralization, resulting in a broader clay particle size distribution and ultimately leading to the formation of a thin and compact filter cake.
Molecular insights into the anti‐inflammatory activity of fermented pineapple juice using multimodal computational studies
Authors: Tallei Trina Ekawati , Fatimawali  , Adam Ahmad Akroman , Ekatanti Dewi , Celik Ismail , Fatriani Rizka , Nainu Firzan , Kusuma Wisnu Ananta , Rabaan Ali A. , Idroes Rinaldi 
Published: October 2023

AbstractPineapple has been recognized for its potential to enhance health and well‐being. This study aimed to gain molecular insights into the anti‐inflammatory properties of fermented pineapple juice using multimodal computational studies. In this study, pineapple juice was fermented using Lactobacillus paracasei, and the solution underwent liquid chromatography‐mass spectrometry analysis. Network pharmacology was applied to investigate compound interactions and targets. In silico methods assessed compound bioactivities. Protein–protein interactions, network topology, and enrichment analysis identified key compounds. Molecular docking explored compound–receptor interactions in inflammation regulation. Molecular dynamics simulations were conducted to confirm the stability of interactions between the identified crucial compounds and their respective receptors. The study revealed several compounds including short‐chain fatty acids, peptides, dihydroxyeicosatrienoic acids, and glycerides that exhibited promising anti‐inflammatory properties. Leucyl–leucyl–norleucine and Leu–Leu–Tyr exhibited robust and stable interactions with mitogen‐activated protein kinase 14 and IκB kinase β, respectively, indicating their potential as promising therapeutic agents for inflammation modulation. This proposition is grounded in the pivotal involvement of these two proteins in inflammatory signaling pathways. These findings provide valuable insights into the anti‐inflammatory potential of these compounds, serving as a foundation for further experimental validation and exploration. Future studies can build upon these results to advance the development of these compounds as effective anti‐inflammatory agents.
RETRACTED: Geo‐archaeological prospecting of Gunung Padang buried prehistoric pyramid in West Java, Indonesia
Authors: Natawidjaja Danny Hilman , Bachtiar Andang , Nurhandoko Bagus Endar B. , Akbar Ali , Purajatnika Pon , Daryono Mudrik R. , Wardhana Dadan D. , Subandriyo Andri S. , Krisyunianto Andi , Tagyuddin  , Ontowiryo Budianto , Maulana Yusuf 
Published: October 2023

AbstractThe multidisciplinary study of Gunung Padang has revealed compelling evidence of a complex and sophisticated megalithic site. Correlations between rock stratifications observed through surface exposures, trenching and core logs, combined with GPR facies, ERT layers, and seismic tomograms, demonstrate the presence of multi‐layer constructions spanning approximately 20–30 m. Notably, a high‐resistive anomaly in electric resistivity tomography aligns with a low‐velocity anomaly detected in seismic tomography, indicating the existence of hidden cavities or chambers within the site. Additionally, drilling operations revealed significant water loss, further supporting the presence of underground spaces. Radiocarbon dating of organic soils from the structures uncovered multiple construction stages dating back thousands of years BCE, with the initial phase dating to the Palaeolithic era. These findings offer valuable insights into the construction history of Gunung Padang, shedding light on the engineering capabilities of ancient civilizations during the Palaeolithic era.
Advanced learning methods in maritime education and training: A bibliometric analysis on the digitalization of education and modern trends
Authors: Türkistanli Taha Talip 
Published: October 2023

AbstractThe minimum requirements in maritime education and training (MET) are set by the International Convention on Standards of Training, Certification and Watchkeeping for Seafarers (STCW). First established in 1978, the STCW convention standardized educational procedures for seafarers. Since then, it has become the most influential regulatory document for maritime education. The STCW code had major revisions in 1995 and 2010. These amendments were in response to the recognized need to bring the Convention up to date. However, it has been over a decade since the latest amendments came into force, and over the past decade, new educational technologies and digital educational methods have developed significantly. Not only that, but technologies used onboard ships have also advanced considerably. Today, digitalization and the fourth industrial revolution are rapidly reshaping the maritime industry, as well as maritime education. These issues coupled with the disruption caused by the Covid pandemic increased the need for more advanced training tools and methods in MET. Concerns are rising regarding the need for more comprehensive rules that will better reflect today's educational needs and progress in the literature. This paper takes a first step toward addressing these issues by improving the understanding of the currently used advanced teaching methods in MET. This bibliometric review provides developments in the field from the perspective of educators and researchers. As a result, we discovered several narratives and literature gaps in MET. This article reviews the currently investigated subjects and topics, used educational tools and equipment, types of research, and main influencers in MET research. The field is still newly developing, but at a rapid pace. Newly developed tools and methods are increasing, but advances are also constrained because they are made to fit the decade‐old regulations.
Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexities
Authors: Ahuja Sana , Zaheer Sufian 
Published: October 2023

AbstractPhysiological embryogenesis and adult tissue homeostasis are regulated by transforming growth factor‐β (TGF‐β), an evolutionarily conserved family of secreted polypeptide factors, acting in an autocrine and paracrine manner. The role of TGF‐β in inflammation, fibrosis, and cancer is complex and sometimes even contradictory, exhibiting either inhibitory or promoting effects depending on the stage of the disease. Under pathological conditions, especially fibrosis and cancer, overexpressed TGF‐β causes extracellular matrix deposition, epithelial–mesenchymal transition, cancer‐associated fibroblast formation, and/or angiogenesis. In this review article, we have tried to dive deep into the mechanism of action of TGF‐β in inflammation, fibrosis, and carcinogenesis. As TGF‐β and its downstream signaling mechanism are implicated in fibrosis and carcinogenesis blocking this signaling mechanism appears to be a promising avenue. However, targeting TGF‐β carries substantial risk as this pathway is implicated in multiple homeostatic processes and is also known to have tumor‐suppressor functions. There is a need for careful dosing of TGF‐β drugs for therapeutic use and patient selection.
Simultaneous Echinococcal superinfection in a patient with polycystic liver disease
Authors: Cicerone Ottavia , Lissandrin Raffaella , Brunetti Enrico , Maestri Marcello 
Published: October 2023

Key Clinical MessageConcurrent polycystic liver disease and echinococcus infection can hinder diagnosis. Surgery may be needed for accurate diagnosis and treatment. Multidisciplinary collaboration is crucial.AbstractCystic echinococcosis, caused by Echinococcus granulosus eggs, is a parasitic zoonosis that typically affects humans through accidental ingestion. Polycystic liver disease is a condition characterized by the presence of multiple liver cysts and is often associated with polycystic kidney disease. Here, we present a case of a man in his 70s with a pre‐existing diagnosis of polycystic liver disease. Radiological findings of a suspicious cyst in the S4 segment initially lacked serological evidence of echinococcosis; however, intraoperative confirmation revealed the presence of an echinococcal cyst. This article aims to explore both clinical conditions and highlight the therapeutic considerations for their management. Moreover, we discuss the significance of this unique case, emphasizing the possibility of the coexistence of these two pathologies.
Hydrodeoxygenation of Furfural over Unsupported, SiO2‐supported or Metal‐promoted Mo Carbides: Tunning the Selectivity between 2‐Methylfuran and C10 Furoins Diesel Precursors
Authors: Sosa Letícia F. , de Souza Priscilla M. , Rafael Raphaela A. , Wojcieszak Robert , Marceau Eric , Paul Sébastien , Briois Valérie , Noronha Fabio B. , Toniolo Fabio S. 
Published: October 2023

AbstractThe hydrodeoxygenation of furfural (FF) over Mo carbides in liquid phase at 200 °C, 30 bar of H2 for 4 h in 2‐butanol was investigated. Unsupported and SiO2‐supported Mo carbide with different crystallographic phases (β‐Mo2C/SiO2 and α‐MoC/SiO2), and in the presence of Cu and Ni as promoters were studied. The reactivation treatment under H2 atmosphere of the passivated Mo carbides was investigated by XAS. The results show that Mo is present in different states of oxidation in the passivated catalysts, with more severe oxidation in the bimetallic systems, in which the original carbides are not restored after reactivation. Finally, the product distribution in the HDO of furfural is modified as a function of catalyst oxidation degree. Using the less oxidized Mo carbide (β‐Mo2C), a higher yield to 2‐methylfuran is obtained, while C10 condensation products are formed for the more oxidized catalysts.