bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Stress and Parental Verbal Abuse on Early Childhood Emotional Development
Authors: Rahmadani Efriza , Sumadi Tjipto , Nurjannah Nurjannah 
Published: January 2024

Parents have an important role in stimulating aspects of early childhood emotional development, but when parents are experiencing stress parents often commit acts of verbal abuse against children. This study aims to determine the effect of stress and verbal abuse by parents on the emotional development of children aged 5-6 years. This research is an ex post facto study conducted in the city of Pagar Alam. The population of this study is children aged 5-6 years whose parents' conditions were affected by the Covid-19 pandemic. They will be taken from South Pagar Alam sub-district,. For the research sampling technique using random clusters from 11 Kindergartens, researchers took random samples to represent the research sample, namely as many as 3 Kindergartens. the object of the emotional development of the respondents was 183 children aged 5-6 years, and for stress and acts of verbal abuse the respondents were 183 parents whose children were respondents to the object of emotional development. The data collection technique in this study was observation, and used a questionnaire. The analysis technique in this study uses path analysis. Based on the results of the path analysis (Path Analysis) and the results of the research hypothesis test showed that stress and acts of verbal abuse have a negative effect on children's emotional development, while stress has a positive effect on acts of verbal abuse.
COMPARISON OF SPERM DEFORMITY INDEXES BETWEEN PATIENTS WHO HAVE AND HAVE NOT EXPERIENCED COVID-19
Authors: AKA SATAR Deniz , BAĞCI Rıdvan , DEMİRDELEN Umut 
Published: January 2024

Objective: Ever since its identification in December 2019, the novel coronavirus SARS-CoV-2 has rapidly disseminated worldwide, giving rise to the COVID-19 (coronavirus disease-19) pandemic. The male reproductive system is susceptible to the effects of COVID-19, leading to potential alterations in semen parameters. In this study, we conducted a comparison between patients who have previously contracted COVID-19 and those who have not, specifically focusing on the sperm deformity index (SDI) as a parameter for assessing sperm morphology.
Material and Method: 134 patients over the age of 18 who applied to Hospital Andrology Laboratory between 29 November 2022 and 29 December 2022 were included in the study. Of these, 44 were patients who have had COVID-19, and 90 were patients who have not had COVID-19. These patients were compared in terms of SDI parameter and other semen parameters (ejaculate volume, sperm concentration, total sperm count, total motility, progressive motility and percentage of normal morphology sperm). The calculation of the SDI was performed by dividing the total number of observed deformities by the total count of sperm.
Results: A noteworthy distinction was observed in the SDI values between the two groups, with a statistically significant difference (p0.05).
Conclusion: SDI, one of the semen parameters, was found to be significantly different in both groups. Further comprehensive studies are warranted to thoroughly investigate the impact of COVID-19 on semen parameters.
Musical Bodies, Musical Minds: Enactive Cognitive Science and The Meaning of Human Musicality
Authors: Meals Cory D. 
Published: January 2024

Reseña de Cory D. Meals del libro Musical Bodies, Musical Minds: Enactive Cognitive Science and The Meaning of Human Musicality, de Dylan van der Schyff, Andrea Schiavio y David J. Elliott. Cambridge, MA: The MIT Press, 2022.
Semimajor-axis Jumps as the Activity Trigger in Centaurs and High-perihelion Jupiter-family Comets
Authors: Lilly Eva , Jevčák Peter , Schambeau Charles , Volk Kat , Steckloff Jordan , Hsieh Henry , Fernandez Yanga R. , Bauer James , Weryk Robert , Wainscoat Richard J. 
Published: January 2024

Abstract
We present a dynamical study of 39 active Centaurs and 17 high-perihelion (q > 4.5 au) Jupiter-family comets (JFCs) with a focus on investigating recent orbital changes as potential triggers for comet-like activity. We have identified a common feature in the recent dynamical histories of all active Centaurs and JFCs in our sample that is not present in the history of the majority of inactive population members: a sharp decrease in semimajor axis and eccentricity occurring within the past several hundred years prior to observed activity. We define these rapid orbital changes as “a-jumps.” Our results indicate that these orbital reshaping events lead to shorter orbital periods and subsequently greater average per-orbit heating of Centaur nuclei. We suggest that the a-jumps could therefore be a major trigger of cometary activity on Centaurs and JFCs. Our results further imply that analyses of the recent dynamical histories could be used to identify objects that are currently active or may become active soon, where we have identified three such Centaurs with recent a-jumps that should be considered high-priority targets for observational monitoring to search for activity.
Evidence for a Redshifted Excess in the Intracluster Light Fractions of Merging Clusters at z ∼ 0.8
Authors: Jiménez-Teja Yolanda , Dupke Renato A. , Lopes Paulo A. A. , Dimauro Paola 
Published: January 2024

Abstract
The intracluster light (ICL) fraction is a well-known indicator of the dynamical activity in intermediate-redshift clusters. Merging clusters in the redshift interval 0.18 < z < 0.56 have a distinctive peak in the ICL fractions measured between ∼3800 and 4800 Å . In this work, we analyze two higher-redshift, clearly merging clusters, ACT-CLJ0102-49151 and CL J0152.7-1357, at z > 0.8, using the Hubble Space Telescope optical and infrared images obtained by the RELICS survey. We report the presence of a similar peak in the ICL fractions, although wider and redshifted to the wavelength interval ∼5200–7300 Å. The fact that this excess in the ICL fractions is found at longer wavelengths can be explained by an assorted mixture of stellar populations in the ICL, direct inheritance of an ICL that was mainly formed by major galaxy mergers with the BCG at z > 1 and experienced an instantaneous burst due to the merging event. The ubiquity of the ICL fraction merging signature across cosmic time enhances the ICL as a highly reliable and powerful probe to determine the dynamical stage of galaxy clusters, which is crucial for cluster-based cosmological inferences that require relaxation of the sample.
L’alimentation dans les villes de Gaule du Sud pendant l’Antiquité tardive
Authors: Mion Leïa 
Published: January 2024

Cette étude présente un exemple d’application d’analyses isotopiques d’ossements archéologiques réalisées pour reconstruire les pratiques alimentaires passées. Elle se concentre sur plusieurs populations de la région provençale dont la datation est comprise entre la fin du IIIe et la fin du VIIe s. apr. J.-C. L’objectif est d’explorer les liens entre l’alimentation individuelle, l’environnement et l’identité biologique et culturelle. L’analyse des isotopes stables du carbone et de l’azote dosés directement sur les os permet en effet d’estimer, pour chaque individu, les tendances plutôt herbivores, carnivores ou piscivores de l’alimentation. Les résultats concernant 120 individus de Marseille, Aix-en-Provence, Riez et Digne-les-Bains mettent en évidence une place variable des ressources aquatiques dans l’alimentation provençale et une diversité au sein des groupes montrant l’importance de l’alimentation comme marqueur économique et culturel.
Prácticas culinarias y cambio social en madīnat Qurṭuba (siglos VIII‑XI)
Authors: García García Marcos , Moreno García Marta 
Published: January 2024

La alimentación representa un ámbito de la experiencia humana profundamente influido por disposiciones de naturaleza social y cultural, al ser un medio expresivo de identidad que nos define en relación a otros individuos y grupos. Por ello, a partir del estudio de los restos materiales derivados del consumo con fines culinarios de los productos animales en el pasado, podemos acceder al conocimiento de los hábitos de alimentación y, de esta forma, acercarnos a la identidad sociocultural de los agentes responsables de la generación de dichos residuos. En este trabajo se presentan algunos de los resultados fruto de una investigación que situó el foco de interés sobre el análisis arqueozoológico de una serie de asociaciones faunísticas identificadas como desechos de alimentación y recuperadas en dos sectores integrados en la actual ciudad de Córdoba (Andalucía) como son el arrabal de Šaqunda (s. VIII‑IX) y la Zona Arqueológica de Cercadilla (s. VIII‑XI). En concreto, y sobre la base de las informaciones derivadas del análisis taxonómico –que nos informa sobre las principales especies consumidas– y de las técnicas de preparación del alimento inferidas a partir del examen de las marcas de carnicería y de combustión, se pretende contribuir al estudio de los hábitos de elaboración culinaria y consumo cárnico en la capital de al‑Andalus durante la fase formativa de la nueva sociedad andalusí y, en último término, demostrar la validez de esta aproximación analítica en la investigación sobre el cambio social operado en dicho contexto histórico.
Extraction of Crude Bromelain from Pineapple (<em>Ananas comosus</em> L.) Fruit Waste and it&rsquo;s <em>in vitro</em> Protein Digestibility
Authors: Wiboonsirikul J. , Klahan R. , Khuwijitjaru P. 
Published: January 2024

Purpose: Crude bromelain is abundant in pineapple fruit waste and is possible to use in shrimp farming. The objectives of this present study were to investigate extraction conditions and to evaluate in vitro protein digestibility of the shrimp feed supplemented with the crude bromelain extract.Research Method: Crude bromelain was extracted from pineapple fruit waste with either distilled water or tap water and the pH was adjusted, ranging from 5 to 9. The different ripeness stages and weight ratios of waste to water were further investigated. The highest proteolytic and specific proteolytic activities of the extract were selected for suitable extraction conditions. The in vitro protein digestibility of soybean meal and shrimp feed pretreated with crude bromelain extract was evaluated to determine their feasibility to use in shrimp farming.Findings: The crude bromelain derived from the pH 7 preboiled tap water extract exhibited the highest values of both proteolytic activities. The weight ratio of fruit waste to water of 1:0.5 and a ripeness stage of more than 50% yellow peel were the conditions suitable to obtain the highest values of both activities. The in vitro protein digestibility of shrimp feed pretreated with crude bromelain was 68.68 ± 2.70 %, which indicated promotion capability for protein digestion in shrimp during shrimp farming.Research Limitations: A suitable crushing tool for pineapple peel was not available. Therefore, the fragments after crushing the peel were not consistent. Originality/Value: The crude bromelain can be extracted with tap water and used to supplement shrimp feed for the promotion of digestibility.
TLR4 Ligands in Typhoid Vi Polysaccharide Subunit Vaccines Contribute to Immunogenicity
Authors: Alugupalli Kishore R 
Published: January 2024

Abstract
Activation of B cells and T cells requires the engagement of costimulatory signaling pathways in addition to Ag receptor signaling for efficient immune responses. None of the typhoid Vi polysaccharide (ViPS) subunit vaccines contains adjuvants that could activate costimulatory signaling pathways, yet these vaccines are very immunogenic. I hypothesized that residual TLR ligands present in the ViPS preparation used for making typhoid subunit vaccines account for the robust immune response generated by these vaccines. I show the presence of endotoxin, a potent agonist of TLR4, in ViPS preparations and ViPS vaccines. Furthermore, I found that ViPS obtained from various sources induces the production of proinflammatory cytokines such as IL-6 from mouse peritoneal exudate cells. Unconjugated and tetanus toxoid–conjugated ViPS vaccines activate human and mouse TLR4. Mice deficient in TLR4 or the signaling adaptors MyD88 and Trif (Toll/IL-1R domain–containing adapter inducing IFN-β) are severely impaired in generating anti-ViPS responses to these vaccines. Elimination of the TLR4 agonist in ViPS preparation resulted in the loss of immunogenicity, and addition of lipid A, a known TLR4 agonist, restored the immunogenicity. These data highlight the importance of associated TLR ligands in the immunogenicity of ViPS subunit vaccines.
Successful hybrid management of hypertensive patent ductus arteriosus with unilateral absence of the right pulmonary artery – A case report
Authors: Mazumder Jayitri , Gangopadhyay Debasree , Roy Mahua , Singh Anoop , Laha Somrita , Dutta Joyeeta 
Published: January 2024

ABSTRACT
Unilateral absence of pulmonary artery (UAPA) can be either isolated or associated with other congenital cardiac defects. It is a rare congenital lesion with a diverse clinical presentation. We present a case of absent right pulmonary artery and large patent ductus arteriosus (PDA) with severe unilateral pulmonary hypertension. We describe our strategy of staged ductus arteriosus closure in this patient and successful outcome on long term follow up.
Successful treatment of pulmonary arterial hypertension in a 2-month-old female infant with incontinentia pigmenti: A case report
Authors: Marcia Marta , Coppo Paola , Annoni Giuseppe Alberto , Ferraro Gaetana , Agnoletti Gabriella , Mazza Giuseppe Antonio 
Published: January 2024

ABSTRACT
Incontinentia pigmenti (IP) is a rare X-linked dominant neuroectodermal dysplasia affecting almost exclusively females. It is caused by loss-of-function mutations in the inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma gene, formerly known as NF-κB essential modulator. The disorder is typically identified by peculiar skin findings that develop throughout the 1st year of life. Approximately one-third of patients has ocular and neurologic abnormalities causing severe disability. Defects of hair, nails, and teeth can also occur. Among systemic complications, pulmonary arterial hypertension (PAH) is uncommon but potentially life-threatening. Only six cases have been described in the literature so far, and four of them died before reaching 1 year of age. Herein, we report the case of a 2-month-old girl with IP and severe PAH, successfully treated with pulmonary antihypertensive and anti-inflammatory therapy.
Retrospective study of preoperative sildenafil in prolonged pleural effusion after Fontan
Authors: Fakhri Dicky , Busro Pribadi Wiranda , Rahmat Budi , Purba Salomo , Lilyasari Oktavia , Asou Toshihide 
Published: January 2024

ABSTRACT

Background:
By rerouting the systemic venous return into the pulmonary circulation, the Fontan operation is perhaps the most effective palliative procedure in patients with complex congenital heart disease. The Fontan, however, still comes with several significant complications and morbidities, one of them being postoperative prolonged pleural effusion. In our center from 2017 to 2021, 10% of all our patients who underwent Fontan operation developed prolonged pleural effusion. With this study, we aimed to analyze the preoperative use of sildenafil for 6 months and its role in prolonged pleural effusion after the Fontan operation.

Materials and Methods:
In total, 158 patients were included in the analysis. The cohort was divided into patients who developed prolonged pleural effusion after Fontan surgery (n = 17) and those who did not (n = 141). We analyzed several risk factors and the history of sildenafil use in each group in the cohort. We found that patients who used sildenafil for at least 6 months prior to Fontan surgery versus those who did not use (n = 112 vs. n = 46) were found to be at lower risk of developing prolonged pleural effusion (odds ratio [OR]: 0.32 [confidence interval 95%: 0.11–0.88], P = 0.027).

Conclusion:
Preoperative administration of sildenafil for at least 6 months before Fontan might reduce the risk of postoperative prolonged pleural effusion.
Left pulmonary artery reconstruction using cryopreserved pulmonary homograft
Authors: Talwar Sachin , Jha Pratik Kumar , Choudhury Arindam , Satsangi Amitabh , Choudhary Shiv Kumar 
Published: January 2024

ABSTRACT
In patients with univentricular heart, the Fontan procedure is the final palliation. This is usually staged. A systemic-to-pulmonary artery shunt is performed in the presence of episodes of cyanotic spells in the neonatal period or in some patients in infancy; a bidirectional superior cardiopulmonary anastomosis is preferred early in life. This is followed by the final Fontan palliation on an elective basis later. For an effective bidirectional superior cavopulmonary anastomosis and Fontan palliation, good-sized confluent pulmonary arteries (PAs) are mandatory in addition to favorable hemodynamic data. Patients with discontinuous PAs that are small in size present a surgical challenge at initial palliation as the one described in this report.
Elevated Fras1-related extracellular matrix 3 in isocitrate dehydrogenase 1-mutant astrocytoma World Health Organization grade 4 predicts favorable prognosis in glioma: A bioinformatic and experimental analysis
Authors: Zhang Zuoxin , Huang Guohao , Wang Tingting , Pei Yuchun , Liu Guolong , Yang Lin , Xiang Yan , Chen Qiuzi , Zhou Shuo , Zhou Xingyu , Zheng Xiaoyang , Lv Shengqing 
Published: January 2024

Background and Aim:
World Health Organization (WHO) grade 4 glioma is a malignancy of the central nervous system characterized by refractoriness to treatment and a high mortality rate. Isocitrate dehydrogenase (IDH) mutation is a crucial molecular event for the classification of glioma and associated with prognosis and exploring genetic and molecular differences between IDH mutant and wildtype glioma is crucial. The aim of this study was to investigate the prognostic gene between IDH mutant and wildtype WHO grade 4 glioma and its functional significance.

Materials and Methods:
The mRNA expression profile data of WHO grade 4 glioma were downloaded from the Gene Expression Omnibus and Chinese Glioma Genome Atlas databases. Bioinformatic analysis was performed to identify the differentially expressed genes between IDH1-mutant and wildtype WHO grade 4 glioma. Survival analysis, functional enrichment analysis, immune cell infiltration evaluation, and in vitro experimental validation were conducted to evaluate the prognostic and functional significance of Fras1-related extracellular matrix 3 (FREM3). This study was approved by the Institutional Ethics Committee of Xinqiao Hospital, Third Military Medical University (approval No. 2021-Y068-01).

Results:
Elevated expression of FREM3 in IDH1-mutant WHO grade 4 astrocytoma predicted favorable prognosis in glioma. FREM3 was negatively associated with epithelial–mesenchymal transition (EMT), angiogenesis, and hypoxia; notably, low expression of FREM3 was associated with a higher degree of immune cell infiltration. In vitro experiments demonstrated that high FREM3 expression might attenuate the process of EMT and cellular proliferation in glioma.

Conclusions:
The gene FREM3 plays a major role in IDH1-mutant WHO grade 4 glioma and elevated FREM3 predicts a favorable prognosis of glioma. Further investigation on FREM3 is warranted to elucidate the mechanisms underlying the malignant evolution of glioma.
Evaluation of Esophageal Motility in Obese Patients before and after Bariatric Surgery: Role of Multichannel Intraluminal Impedance and High-resolution Manometry
Authors: Roque Leticia , Mota Gustavo De Assis , Nonino Carla B. , Salgado Júnior Wilson 
Published: January 2024

Abstract

Background:
A high prevalence of esophageal motor disorders has been reported in obese patients. Roux-en-Y gastric bypass (RYGB) can trigger symptoms of dysphagia by worsening preexisting esophageal motor disorders. Investigation of esophageal motility with multichannel intraluminal impedance (MII) and high-resolution manometry (HRM) is available.

Objective:
The aim is to compare the results of MII and HRM of nonobese patients with those of obese patients before and after RYGB to identify possible preoperative predictive factors of postoperative dysphagia.

Materials and Methods:
Twenty-eight obese patients were evaluated with a questionnaire of symptoms, endoscopy, HRM, and MII in different postures (supine and sitting) before and 6 months after laparoscopic RYGB. They were compared with eleven nonobese subjects. Chicago classification parameters were used to characterize esophageal motility disorders.

Results:
Obese patients evolved with more symptoms of dysphagia after surgery (7.10% preoperatively and 32.10% postoperatively). None had gastrojejunal anastomosis stenosis. After bariatric surgery, there was an increase in distal latency (HRM) and also a decrease in esophageal alimentary bolus progression (MII). Twenty-one percent of obese patients already had some dysmotility before the surgery and 92% of them evolved to dysphagia after the operation.

Conclusions:
Previous esophageal motility disorder is a good predictive factor of postoperative dysphagia. HRM and MII should be performed in some situations, such as bariatric surgery for older adults and before narrowing the gastrojejunal anastomosis as a treatment for weight recidivism.
Prevalence and clinical profile of glaucoma in rural-based tertiary care hospital
Authors: Padwal Viraj Sudam , Bhalerao Pradnya , Pawar Smita A. 
Published: January 2024

Abstract

Context:
Glaucoma is the second leading cause of world blindness. Considering the scarcity of glaucoma studies in the Western part of Maharashtra, we conducted this study to determine the prevalence of glaucoma among adults aged 18 years and above.

Aims:
To determine the prevalence and clinical profile of glaucoma in rural-based Tertiary Care Hospital.

Settings and Design:
A cross-sectional study carried out in an Ophthalmology outpatient department in a rural-based Tertiary care hospital.

Materials and Methods:
Five hundred and eighty-three patients underwent ocular examination including visual acuity, slit-lamp examination, optic disc evaluation with +78D lens and intraocular pressure measurement with Goldmann applanation tonometer, gonioscopy, visual fields examination by Humphrey Field Analyzer and optic nerve head analysis using optical coherence tomography scan of all the glaucoma suspects.

Statistical Analysis Used:
The data of patients were tabulated and analyzed using SPSS.

Results:
Out of 583 cases, 42 cases had primary glaucoma; thus, the overall prevalence of glaucoma was found to be 7.2%. The open-angle group had 38 (90.4%) cases, whereas the narrow-angle group had 4 (9.52%) cases. Out of the total of 113 hypertensive patients, 16 were found to have glaucoma (38.09%, P < 0.01), and out of 84 diabetic patients, 14 cases were glaucomatous (33.33%, P < 0.01). The prevalence of glaucoma was found to be significantly associated with a positive family history, as 6 cases (14.3%) out of 42 had a positive family history (P < 0.01).

Conclusions:
The prevalence of glaucoma was found to be high in the population of the rural Western part of Maharashtra. Screening for glaucoma among middle-aged people with a positive family history, hypertension, and diabetes would help us in the early diagnosis and management of this irreversible disease.