bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of dietary inflammatory index, serum inflammatory factors and osteoporosis: a cross-sectional study from Xinjiang, China
Authors: Tong Min , Zhang Huanwen , Li Yuanyuan , Fu Wenhui , Luo Tao , Dai Jianghong , Huang Yifei 
Published: January 2024

Abstract

Background
Previous studies have found the inflammatory potential of the diet is associated with a variety of chronic non-communicable diseases characterized by a chronic low-grade inflammatory response. However, the relationship between dietary inflammatory potential and organismal inflammatory status and osteoporosis has been less studied. This study aims to investigate the relationship between inflammatory diet, inflammatory state and osteoporosis in Xinjiang multi-ethnic population.
Methods
Participants consisted of 4452 adults aged 35 to 74 years from Xinjiang, China. The Dietary Inflammatory Index (DII) was calculated using dietary data collected by the semi-quantitative Food Frequency Questionnaire, and information about osteoporosis was derived from quantitative ultrasound measurements. The relationship between DII, inflammatory factors and osteoporosis was analyzed using multivariate logistic regression, and the non-linear association between DII and osteoporosis was further analyzed using restricted cubic splines.
Results
The results showed pro-inflammatory diets were associated with a higher risk of osteoporosis (T3 vs T1: OR = 1.87; 95% CI = 1.44, 2.45) and that there was no non-linear relationship between DII and the risk of osteoporosis. Increased concentrations of inflammatory factors IL-6, IL-10, IL-12p70, IL-17, and IL-23 were associated with a higher risk of osteoporosis.
Conclusions
The risk of osteoporosis can be reduced by increasing the consumption of an appropriate anti-inflammatory diet.
WITHDRAWN: The economic effect of sex and germinated sprout feed onthe growth performance of new hybrid broiler chickens for environmental adaptation in Egypt
Authors: Arafa Abdelsatar 
Published: January 2024

Abstract

In this study, a total of 360 one-day-old birds (180 males and 180 females) of a new hybrid broiler (WINZY line 105) were raised to 8 weeks of age. Birds were randomly taken to be similar in body weight (33.9 ± 0.58) and divided into four groups (90 birds in each group) in three replicates (30 birds/replicate). The experimental groups involved a 2X 2 factorial arrangement, two sex groups (male (M) and female (F)), and two types of rations (basal diet from one day up to 56 days and basal diet plus germinated sprouts from 28 to 56 days of age). The birds were reared in controlled, semi-closed houses in winter, aiming to simulate the effects of sex and ration type on productive, physiological and economic efficiency for environmental adaptation. Sex is the main determinant of broiler performance. Compared with females, males had significantly (P≤01) greater body weight, body weight gain, feed intake, feed conversion, carcass weight and economic efficiency. Body weight, feed intake and feed conversion gain were improved for the chicks fed a basal diet plus germinated sprout feed in comparison to those of the other groups fed only basic rations. The carcass yield, abdominal fat percentage, total antioxidant capacity, cholesterol and low-density lipoprotein content were greater for males fed a basal diet plus germinated sprouts than for those in the other groups, and the net return economic efficiency percentage was also greater. In conclusion, the use of germinated sprout feed improved birds' productivity and physiologic and economic efficiency, especially in males. This work highlighted the importance of breeding characteristics and feeding type on the growth performance of broilers and will help to select and improve their traits against environmental stresses.
Exploring the Vibrational Characteristics of Wind Turbine Drivelines
Authors: Mohamedi Walid 
Published: January 2024

Abstract
The significance of understanding these vibrational characteristics cannot be overstated. It serves as a foundational element for enhancing the overall reliability of wind turbines. Identifying and comprehending the root causes of vibrations empower maintenance teams to optimize strategies, addressing issues before they escalate into major concerns. This proactive approach is instrumental in preventing catastrophic failures, minimizing downtime, and ultimately ensuring the extended longevity of wind energy systems. As we navigate through the vibrational landscape of wind turbine drivelines, this detailed exploration aims to shed light on the nuanced dynamics at play. By doing so, we contribute to the collective knowledge base that fuels advancements in wind energy technology. From the intricacies of mechanical resonance to the impact of external forces, this examination provides valuable insights that pave the way for more resilient and efficient wind turbine designs in the pursuit of sustainable energy solutions.
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
Authors: Uchaipichat Verawan 
Published: January 2024

Background::
Tricyclic antidepressants (TCAs) are commonly co-administered with morphine as an adjuvant analgesic. Nevertheless, there remains a lack of information concerning metabolic drug-drug in-teractions (DDIs) resulting from TCA inhibition on morphine glucuronidation.

Objective::
This study aimed to (i) examine the inhibitory effects of TCAs (viz., amitriptyline, clomipramine, imipramine, and nortriptyline) on human liver microsomal morphine 3- and 6-glucuronidation and (ii) evalu-ate the potential of DDI in humans by employing in vitro-in vivo extrapolation (IVIVE) approaches.

Method::
The inhibition parameters for TCA inhibition on morphine glucuronidation were derived from the in vitro system containing 2% BSA. The Ki values were employed to predict the DDI magnitude in vivo by us-ing static and dynamic mechanistic PBPK approaches.

Results::
TCAs moderately inhibited human liver microsomal morphine glucuronidation, with clomipramine exhibiting the most potent inhibition potency. Amitriptyline, clomipramine, imipramine, and nortriptyline competitively inhibited morphine 3- and 6-glucuronide formation with the respective Ki values of 91 ± 7.5 and 82 ± 11 μM, 23 ± 1.3 and 14 ± 0.7 μM, 103 ± 5 and 90 ± 7 μM, and 115 ± 5 and 110 ± 3 μM. Employing the static mechanistic IVIVE, a prediction showed an estimated 20% elevation in the morphine AUC when co-administered with either clomipramine or imipramine, whereas the predicted increase was <5% for ami-triptyline or nortriptyline. PBPK modelling predicted an increase of less than 10% in the morphine AUC due to the inhibition of clomipramine and imipramine in both virtual healthy and cirrhotic populations.

Conclusion::
The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antide-pressant inhibition on morphine glucuronidation is low.
Understanding the Challenges Associated with Approval of Anticancer
Products to Facilitate the Regulatory Approvals: A Cross-sectional Study
Authors: Sharma Pinky , Jhawat Vikas , Singh Jatinder , Dutt Rohit 
Published: January 2024

Purpose:
Oncological medications face a myriad of challenges, including technological,
pre-clinical, clinical, and manufacturing, that lead to regulatory approval delays or failures. The present
study aims to identify some challenges encountered by researchers or regulators during the development
of novel cancer therapies.

Methods:
The present cross-sectional observational study used a mixed-method design methodology.
The participants were selected via a non-random sampling method via self-selection and snowballing
approach. A survey questionnaire was developed and circulated among the selected participants as a
hard copy or email or a Google form. Open-ended and closed-ended questions were incorporated to
identify the regulatory challenges faced during oncology drug development. The responses were collected
from September 2021 to June 2022. These responses were then coded and themes were identified
for the challenges.

Results:
A total of 87 responses were obtained for the questionnaire among the individuals contacted.
Seven themes were identified from the collated responses that depicted the challenges for the regulatory
approval of anticancer drug products. The majority of responders (38.2%) suggested reduced
approval time whereas endpoint selection and study design were considered as a challenge by 12.0%
of responders each. Furthermore, 6.0% of responders admit that timely interaction with the regulators
is also a challenge that delays approval. Many challenges also exist during the product development
phase; hence, 12.0% of responders reported safety issues, and 22.0% of responders reported technical
issues during manufacturing as the cause of regulatory failure. Moreover, 12.0% of responders suggested
the need for improvements in regulatory guidelines for oncology drug development.

Conclusion:
The survey indicates a lack of Indian guidelines for anticancer products, whereas limited
guidance is available from other countries such as Europe or the United States. Thus, the survey
points to the necessity for improvement in the regulatory guidelines and drug approval process to address
the challenges unique to cancer drug development.
Impact of Ramadan Fasting on Cardiometabolic and Inflammatory
Biomarkers among Saudi Adults with Diabetes
Authors: Aljahdali Abeer , Al-Maiman Reham , Al-Orf Saada , Bawazeer Nahla 
Published: January 2024

Background and Aims:
Diabetes is prevalent in Saudi Arabia. As dietary concerns are
central in patients with diabetes, the impact of fasting on health during Ramadan is potentially
significant. Decreased meal frequency and changes in food type and amount affect body weight
and metabolic profiles. This study aimed to investigate the association between Ramadan fasting
and anthropometric measurements and cardiometabolic and inflammatory biomarkers in Saudi
adults with diabetes.

Methods:
Sixty-eight Saudi adults with diabetes, admitted at the University Diabetes Centre in
Riyadh, Saudi Arabia, were enrolled in this study. Participants were evaluated at the following
time points: six weeks before Ramadan (pre-fasting) and at least 15 days after the initiation of
Ramadan (peri-fasting). Anthropometric measurements and cardiometabolic and inflammatory
biomarker levels were assessed during both visits.

Results:
After accounting for confounding factors, Ramadan fasting was found to be associated
with reduced body weight (kg), waist circumference (cm), and hip circumference (cm). Increased
log high-density lipoprotein-cholesterol and decreased log interleukin 6 and C-reactive protein
levels were observed.

Conclusions:
Ramadan fasting was associated with increased HDL-C levels and decreased anthropometric
measurements and inflammatory cytokine levels. These results support the beneficial
role of Ramadan fasting in reducing cardiometabolic abnormalities and inflammation in
adults with diabetes.
Montelukast Ameliorates 2K1C-Hypertension Induced Endothelial
Dysfunction and Associated Vascular Dementia
Authors: Gupta Surbhi , Singh Prabhat , Sharma Bhupesh 
Published: January 2024

Background:
Declined kidney function associated with hypertension is a danger for
cognitive deficits, dementia, and brain injury. Cognitive decline and vascular dementia (VaD)
are serious public health concerns, which highlights the urgent need for study on the risk factors
for cognitive decline. Cysteinyl leukotriene (CysLT1) receptors are concerned with regulating
cognition, motivation, inflammatory processes, and neurogenesis.

Objective:
This research aims to examine the consequence of montelukast (specific CysLT1 antagonist) in renovascular hypertension 2-kidney-1-clip-2K1C model-triggered VaD in experimental animals.

Methods:
2K1C tactics were made to prompt renovascular hypertension in mature male rats.
Morris water maze was employed to measure cognition. Mean arterial pressure (MAP), serum
nitrite levels, aortic superoxide content, vascular endothelial activity, brain’s oxidative stress
(diminished glutathione, raised lipid peroxides), inflammatory markers (IL-10, IL-6, TNF-α),
cholinergic activity (raised acetylcholinesterase), and cerebral injury (staining of 2, 3, 5-
triphenylterazolium chloride) were also examined.

Results:
Montelukast in doses of 5.0 and 10.0 mg kg-1 was used intraperitoneally as the treatment drug. Along with cognitive deficits, 2K1C-operated rats showed elevated MAP, endothelial
dysfunction, brain oxidative stress, inflammation, and cerebral damage with diminished serum
nitrite/nitrate. Montelukast therapy significantly and dose-dependently mitigated the 2K1Chypertension-provoked impaired behaviors, biochemistry, endothelial functions, and cerebral infarction.

Conclusion:
The 2K1C tactic caused renovascular hypertension and associated VaD, which was
mitigated via targeted regulation of CysLT1 receptors by montelukast administration. Therefore,
montelukast may be taken into consideration for the evaluation of its complete potential in renovascular-hypertension-induced VaD.
S-Dihydrodaidzein and 3-(1,3-benzoxazol-2-yl)-benzamide, Two New
Potential β-estrogen Receptor Ligands with Anti-adipogenic Activity
Authors: Torres-Rojas María F. , Mandujano-Lazaro Gilberto , Lopez-Camarillo Cesar , Ramirez-Moreno Esther , Mendez-Alvarez Domingo , Rivera Gildardo , Marchat Laurence A. 
Published: January 2024

Background:
The elucidation of molecular pathways associated with adipogenesis has
evidenced the relevance of estrogen and estrogen receptor beta (ERβ). The positive effects of ERβ
ligands on adipogenesis, energy expenditure, lipolysis, food intake, and weight loss, make ERβ an
attractive target for obesity control. From ligand-based virtual screening, molecular docking, and
molecular dynamic simulations, six new likely ERβ ligands (C1 to C6) have been reported with
potential for pharmacological obesity treatment.

Objective:
In this study, the effect of molecules C1-C6 on adipogenesis using the murine 3T3-L1
cell line was evaluated.

Methods:
Cell viability was assessed by MTT assays. Lipid accumulation and gene expression
were investigated by ORO staining and real-time quantitative RT-PCR experiments, respectively.

Results:
Cell viability was not significantly affected by C1-C6 at concentrations up to 10 μM. Interestingly,
treatment with 10 μM of C1 (S-Dihydrodaidzein) and C2 (3-(1,3-benzoxazol-2-yl)-
benzamide) for 72 h inhibited adipocyte differentiation; moreover, ORO staining evidenced a reduced
intracellular lipid accumulation (40% at day 7). Consistently, mRNA expression of the adipogenic
markers, PPARγ and C/EBPα, was reduced by 50% and 82%, respectively, in the case of
C1, and by 83% and 59%, in the case of C2.

Conclusion:
Altogether, these results show the two new potential β-estrogen receptor ligands, C1
and C2, to exhibit anti-adipogenic activity. They could further be used as lead structures for the
development of more efficient drugs for obesity control.
Computational Approaches Molecular Docking and MD Simulation
Establishes the Potential COVID-19 Main Protease Inhibitors from
Natural Products
Authors: Zehra Areesh , Nisha Raquibun , Kumar Abhishek , Nandan Durgesh , Ahmad Iqrar , Mahapatra Debarshi Kar , Patel Harun , Maity Biswanath , Kumar Pranesh 
Published: January 2024

Aim:
COVID-19 was classified as a pandemic by the World Health Organization
(WHO) on March 11, 2020. No reliable cure, however, was found. To prevent viral replication,
complementary therapy with antiviral and antimalarial medications were used. However, due to
their synthetic origin, they have a lot of side effects. To overcome this bane natural origin drugs
were repositioned.

Background:
As repositioned drugs do not undergo a pro-long process of pre-clinical trial, hence,
they play an excellent role in the spillover of pathogens. The main protease (6LU7) enzyme found
in severe acute respiratory syndrome coronavirus-2 (SAR-CoV-2) is essential for viral replication.
Thus, it acts as a hotspot in drug discovery.

Objective:
A molecular docking computational approach was used to determine the ability of the binding contract between the selected 3D-models of COVID-19 protease target and proposed natural compounds pristimerin, amazoquinone, kendomycin, celastrol, 20-epi-isoguesterinol, phenanthrenequinone,
taxodione, maytenoquinone, hippeastrine, ammothamnine, 28-hydroxy isoiguesterin, hemanthamine,
alisol-B, stigmasterol, β-pinene,and β-sitosterol through Autodock v.1.5.6 software.

Method:
The present study is designed to perform in-silico studies using molecular docking (Autodock tool v.1.5.6), Discovery Studio 2017 R2 client, Patch dock, SWISS-ADME prediction, and
molecular simulation (Desmond simulation package of Schrodinger) between 6LU7 and natural
origin compounds.

Result:
The results of docking study performed between 6LU7 and compounds pristimerin, amazoquinone, kendomycin, celastrol, 20-epi-isoguesterinol, phenanthrenequinone, taxodione, maytenoquinone, hippeastrine, ammothamnine, 28-hydroxy isoiguesterin, hemanthamine, alisol-B,
stigmasterol, β-pinene, and β-sitosterol, showed binding energy as -9.68, -7.34, -5.34, -4.63, -4.24,
-4.13, -4.08, -3.85, -3.83, -3.7, -3.6, -3.57, -3.54, -3.39, -3.18, and -3.03 Kcal/mol, respectively. It
can be shown that the Pristimerin-6LU7 protein complex was maintained throughout the simulation since the ligand RMSDs varied with a maximum value of 4.2Å during the first 10 ns, followed by more stable interactions for the remaining time of the simulation.

Conclusion:
The goal of the current work was to find inhibitors for both prophylactic and
therapeutic usage in COVID-19 patients.
Frameworks, Dimensions, Definitions of Aspects, and Assessment Methods for the Appraisal of Quality of Health Data for Secondary Use: Comprehensive Overview of Reviews
Authors: Declerck Jens , Kalra Dipak , Vander Stichele Robert , Coorevits Pascal 
Published: January 2024

Background
Health care has not reached the full potential of the secondary use of health data because of—among other issues—concerns about the quality of the data being used. The shift toward digital health has led to an increase in the volume of health data. However, this increase in quantity has not been matched by a proportional improvement in the quality of health data.

Objective
This review aims to offer a comprehensive overview of the existing frameworks for data quality dimensions and assessment methods for the secondary use of health data. In addition, it aims to consolidate the results into a unified framework.

Methods
A review of reviews was conducted including reviews describing frameworks of data quality dimensions and their assessment methods, specifically from a secondary use perspective. Reviews were excluded if they were not related to the health care ecosystem, lacked relevant information related to our research objective, and were published in languages other than English.

Results
A total of 22 reviews were included, comprising 22 frameworks, with 23 different terms for dimensions, and 62 definitions of dimensions. All dimensions were mapped toward the data quality framework of the European Institute for Innovation through Health Data. In total, 8 reviews mentioned 38 different assessment methods, pertaining to 31 definitions of the dimensions.

Conclusions
The findings in this review revealed a lack of consensus in the literature regarding the terminology, definitions, and assessment methods for data quality dimensions. This creates ambiguity and difficulties in developing specific assessment methods. This study goes a step further by assigning all observed definitions to a consolidated framework of 9 data quality dimensions.
Pathophysiological features of thyroid dysfunction in patients with type 2 diabetes and chronic kidney disease (a literature review and own observations)
Authors: Urbanovych A.M. , Vereshchynska A.P. 
Published: January 2024

Background. Diabetes mellitus (DM) is a metabolic di­sease that causes disorders of all types of metabolism. Currently, there is an increasing prevalence of not only DM, but also its serious complications. One of the common chronic complications of DM is diabetic kidney disease (DKD). As of today, it is also known about the effect of DM on other endocrine organs, in particular thyroid gland. Thyroid dysfunction in combination with type 2 DM and DKD are interrelated conditions. In the literature review, the causes, theories of development, stages, course, and criteria for making a diagnosis of DKD are highlighted, probable mechanisms for the development of phenotypes are described. The impact of pathophysio­logical mechanisms of metabolic and secretory disorders on thyroid function has been demonstrated. PubMed and Google Scholar databases were used to search for literature data. The purpose of the study is to investigate the frequency and prevalence of phenoty­pic forms of DKD and the thyroid functional state. Materials and methods. We have analyzed the data of 1,874 patients with type 2 DM who were receiving inpatient treatment at the Lviv Regional Clinical Diagnostic Center, branch of the Center for Endocrinolo­gical Population Health, in 2022 and the first three quarters of 2023. Among them, 56 % were women, 44 % were men. The average age of the patients was 56.1 ± 8.2 years. The frequency and prevalence of phenotypic forms of DKD, the thyroid functional state in such patients were studied. Results. The share of patients with confirmed DKD was 26 % (n = 487). According to the results of the studies, DKD develops by a phenotype of non-albuminuric renal dysfunction in 288 patients (59 %), by an albuminuric phenotype — in 192 cases (39.6 %), and as a progressive decrease in kidney function — in 7 patients (1.4 %). Non-albuminuric renal dysfunction phenotype was 1.5 times more frequent than albuminuric one. Thyroid dysfunction was diagnosed in 166 patients with DKD (34 %). The obtained data confirm the greater prevalence of hypothyroidism as compared to hyperthyroidism in patients with DKD. This allows us to suspect that the structural and functional changes in the kidneys in type 2 DM, which lead to a decrease in the filtration capacity of the kidneys, may be independent of albuminuria. Conclusions. The presence of DKD, regardless of the stage of DM and phenotype, has a direct and indirect effect on the regulation and functioning of the thyroid gland. In turn, adequate production of thyroid hormones is necessary for a balanced metabolism, energy homeostasis and renoprotection. The presence of thyroid dysfunction can be a cause of unsatisfactory control of diabetes and lead to the development of complications.
Das análises de gêneros textuais/discursivos às propostas didáticas
Authors: Alves Filho Francisco , Pereira Daniervelin , Abreu-Tardelli Lilia 
Published: January 2024

Este dossiê Das análises de gêneros textuais/discursivos às propostas didáticas apresenta como temática geral os gêneros textuais/ discursivos em sua relação também com aplicações didáticas, sendo composto por oito artigos, uma entrevista e uma resenha. As análises de gêneros textuais/discursivos têm colaborado para as pesquisas em linguística aplicada tanto em relação às reflexões e avanços teórico-metodológicos de análises como em relação a avanços em propostas didáticas e formativas. Dessa forma, este volume se propõe a reunir artigos em relação ao gênero textual/discursivo enquanto objeto de análise, assim como enquanto ferramenta didático-pedagógica de ensino