bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of reducing meat and dairy consumption on nutrient intake, health, cost of diets and the environment: A simulation among adults in Scotland
Authors: Kennedy Joe , Clark Michael , Stewart Cristina , Runions Ricki , Vonderschmidt Alexander , Frank Sarah , Scarborough Peter , Comrie Fiona , McDonald Alana , McNeill Geraldine , Alexander Peter , Jaacks Lindsay 
Published: February 2025

Abstract

In a representative sample of Scottish adults, we evaluate 33 pathways to meeting the UK Climate Change Committee’s (CCC) recommendations to reduce all meat and dairy consumption by 20% by 2030, rising to a reduction of 35% in meat by 2050. Our pathways take into account existing dietary guidance, and modelled outcomes include intakes of 54 nutrients, obesity, type 2 diabetes and cardiovascular disease, all-cause mortality, cost of diets, greenhouse gas emissions, water and land use, and eutrophication. Nearly all modelled pathways are estimated to have benefits for most nutrition, health, and environmental outcomes, without negatively affecting diet costs. These benefits could be increased with targeted reductions in red meat among high consumers of red meat, and gram-for-gram replacement of meat and dairy with substitutes ranging from vegetables to beans to eggs to plant-based dairy alternatives.
Magnetic resonance imaging findings in Ghanaian patients presenting with low back pain: A single centre study
Authors: Acquah Godwill , Sule Derick Seyram , Fesi Lawrence , Kyei Kofi Adesi , Ago Jacob Leonard , Agala Dennison , Antwi William K. 
Published: February 2025

Abstract

Background
Due to the high prevalence of low back pain which impacts the lives of those affected, several studies have explored findings associated with the lumbar spine which is the affected anatomy using magnetic resonance imaging (MRI). This provides a better understanding of the pathology in the study setting and adds to the literature on the subject which is useful during intervention. However, there is a paucity of literature in the Ghanaian context. This study therefore explored the patterns of MRI findings in patients with low back pain.
Method
A one-year retrospective cross-sectional design with a purposive sampling method was used to retrieve data from 59 MRI lumbar spine radiologist reports with a clinical history of low back pain. Data was analysed using SPSS v26 and Jamovi 2.5.6. Statistical significance was deduced at p < 0.05.
Results
Radiological reports with a history of low back pain accounted for 32.6% of the total (n = 181) reports identified. A male-to-female ratio of 0.74:1 was identified with a mean age of 44.7 ± 16.1 years. Disc degeneration (93.2%, n = 55) and lumbar spondylolysis (76.3%, n = 45) were the two main findings identified as the most prevalent across reports. The lordotic curvatures of patients with low back pain were predominantly normal (74.6% n = 44). Disc degeneration was strongly associated with L4/L5 (V = 0.644).
Conclusion
The prevalent finding identified was disc degeneration frequently located at L4/L5. While this study could be a stepping stone for future research in this context, it provides some level of evidence which could be useful to Ghanaian healthcare providers for more focused assessments and interventions. This targeted approach can enhance diagnostic accuracy and improve treatment outcomes for patients suffering from low back pain, facilitating timely and appropriate management strategies.
Clinical trial number
Not applicable
The Mix and Match Approach in Primary Total Hip Arthroplasty Reveals Comparable or Lower Revision Rates to Matched Components: A Systematic Review.
Authors: Leitner Lukas , Postruznik Magdalena , Draschl Alexander , Koutp Amir , Leithner Andreas , Sadoghi Patrick 
Published: February 2025

Abstract

Introduction: The mix and match (stem and cup from different manufacturers/systems, MM) approach in primary total hip arthroplasty (THA) involves combining components from different manufacturers. Despite various configurations discussed in literature and evidence supporting the safety of MM, controversy persists regarding safety and long term outcomes compared to matched components. Our study aimed to compare the revision rates of MM versus matched components.
Materials and Methods: Two databases were searched for English full-text articles published until January, 2024 that evaluated revision rates after primary MM THA. Additionally, MM revision rates data was extracted from the German Arthroplasty Registry (EPRD). The Newcastle-Ottawa Scale (NOS) for cohort studies was used for quality assessment.
Results: Three national and one hospital registry studies were included, of which three demonstrate MM as a common practice (19-24%). All studies found comparable revision rates for MM cohorts, or even slightly improved survival rates in MM cohorts concerning revision rate and PROMs, mostly lacking clinical relevance. These findings align with the data reported in the EPRD, with revision rates of approximately 3.6% after 6 years in both MM and matched THA.
Conclusions:Employing MM in primary THA presents a feasible and safe approach, capable of providing custom fit tailored to individual patients with revision rates comparable to those of matched THA.
Pt nanoparticles breathe and reversibly detach from Al2O3 in hydrogen
Authors: Checchia Stefano , Bonavia Daniele , Ferri Davide , Alxneit Ivo , Groppo Elena , Ricchebuono Alberto , Lazzarini Paolo , Vottero Eleonora , Pellegrini Riccardo , Piovano Andrea , Dejoie Catherine , Chizallet Céline , Raybaud Pascal 
Published: February 2025

Abstract

The dynamic behavior of supported metal nanoparticles under reaction conditions is a key factor in their catalytic performance. Pt nanoparticles are particularly susceptible to structural relaxation and disordering induced by adsorbed CO and H2. In a hydrogenated state, theoretical models have predicted not only the reshaping of Pt nanoparticles, but also their shift away from the surface of their metal oxide support. In this work we examined the dynamic behavior of well-dispersed 1–3 nm diameter Pt nanoparticles under hydrogenation conditions. Using time-resolved X-ray diffraction and pair distribution function analysis allied to a modulated-excitation approach, we provide direct experimental evidence of the simultaneous “breathing” of the Pt nanoparticles and their detachment from the Al2O3 support under H2 atmosphere. These dynamic structural changes are shown to be size-dependent, to occur in both gas phase (150°C) and liquid phase (cyclohexane, 70°C), and to be reversible, thus ensuring the stability of the catalyst under hydrogenation conditions. Gaining direct structural evidence of the ductile behavior of supported metal nanoparticles in reactive chemical environments is a groundbreaking step towards precise structural control of catalysts under reaction conditions.
Factors Associated with Hospitalizations Due to Severe Malaria in the Non-Endemic Brazilian Region: A Case-Control Study in the Extra-Amazon Region from 2011 to 2019
Authors: Silva Anderson Coutinho , Duarte Elisabeth Carmem , Marchesini Paola Barbosa , Viana Giselle Maria Rachid , Ramalho Walter Massa , Garcia Klauss K. S. 
Published: February 2025

Abstract

Background
Malaria is an acute infectious disease with its occurrence in Brazil concentrated in the Amazon region. But it is in the extra-amazon region where the lethality is higher. Therefore, this study aimed to analyze factors associated with malaria hospitalizations in the extra-Amazon region of Brazil.
Methods
A case-control design was used, utilizing data from the Brazilian Notifiable Diseases Information System (Sinan) and hospitalization records from the Unified Health System (SIH/SUS) from 2011 to 2019. Cases comprised hospitalized malaria patients, while controls included reported malaria cases without hospitalization. Probabilistic record linkage techniques were employed, and associations were analyzed using multiple logistic regression with a 0.05 significance level.
Results
There were 2137 hospitalizations, and the risk factors identified were people with: Black or mixed-race ethnicity, low education, infected in the Amazon region or abroad, or infected by P. falciparum or mixed infections, and delayed treated. Active case detection was found as a protective factor.
Conclusions
The results highlight a need for reinforcing timely diagnosis and treatment, while aiming at health equity measures. Strengthening diagnostic networks and effective communication strategies is critical to reducing complications and achieving malaria deaths elimination goals by 2030.
Accuracy verification of the CT-based navigation system ‘OTS’ for severe hip dysplasia: A simulation using 3D bone models of Crowe types II, III, and IV
Authors: Okuda Ryuichiro , Tetsunaga Tomonori , Yamada Kazuki , Tetsunaga Tomoko , Koura Takashi , Inoue Tomohiro , Masada Yasutaka , Ozaki Toshifumi 
Published: February 2025

Abstract

Introduction: Ortoma Treatment Solution (OTS) is a computer-assisted artificial intelligence (AI)-based orthopedic surgical platform. However, its application in severe hip dysplasia has not been reported. This study aimed to evaluate the accuracy of OTS in patients with severe hip dysplasia using three-dimensional (3D) bone models.
Materials and Methods: 3D bone models of severe hip dysplasia (Crowe type II, 10 hips; type III, 10 hips; and type IV, 10 hips) were constructed. The accuracy of automatic AI segmentation, success rate, point matching accuracy across different matching methods, and deviation values at reference points after matching were assessed.
Results: The overlap accuracy of segmentation was 1.00 ± 0 in the Crowe II group, 0.99 ± 0.02 in the Crowe III group, and 0.96 ± 0.06 in the Crowe IV group. The "Matching with true and false acetabulum + iliac crest" method achieved a 100% success rate across all groups, with mean deviations of 0.08 ± 0.27 mm in the Crowe II group, 0.12 ± 0.33 mm in the Crowe III group, and 0.14 ± 0.50 mm in the Crowe IV group (P = 0.572). In the Crowe IV group, the anterior superior iliac spine deviation was significantly lower using the "Matching with true and false acetabulum + iliac crest" method compared to the "Matching with true and false acetabulum" method (0.28 ± 0.49 mm vs. 3.29 ± 2.56 mm, P = 0.030).
Conclusions: Segmentation accuracy for severe hip dysplasia was very high. The matching success rate was 100%, with additional points on the iliac crest, which improved matching accuracy and reduced deviations, depending on the case.
β-Catenin interacts with a Wnt signaling mRNA network in myeloid leukaemia cells through canonical RBP binding.
Authors: Morgan Rhys , Wagstaff Megan , Sevim Okan , Goff Aaron , Raynor Morag , Park Hyun , Mancini Erika , Nguyen Diu , Chevassut Timothy , Blair Allison , castellano leandro , Newbury Sarah , Towler Ben 
Published: February 2025

Abstract

Wnt/β-catenin signaling is important for normal hematopoietic stem/progenitor cell (HSPC) biology and heavily implicated in acute myeloid leukaemia (AML). The central mediator β-catenin is an attractive therapeutic target in AML however its targeting has been hampered by a poor characterisation of its molecular interactions in haematopoietic cells, which will differ from its network in solid tissues. Our previous β-catenin interactome study identified the significant enrichment of RNA-binding proteins (RBP) implying post-transcriptional roles for β-catenin in myeloid cells. To identify β-catenin interacting mRNAs we performed β-catenin RNA-immunoprecipitation coupled to RNA-sequencing (RIP-seq) and identified significantly enriched Wnt signalling pathway transcripts. Using β-catenin cross-linking immunoprecipitation (CLIP) we demonstrated a limited capacity for β-catenin to bind RNA directly implying dependence on other RBPs. β-Catenin was found to interact with MSI2 in both myeloid cell lines and AML patient samples, where expression was significantly correlated. MSI2 knockdown reduced Wnt signalling output (TCF/LEF activity), through suppression of LEF-1 expression and nuclear localization. Through both RIP and CLIP we demonstrate MSI2 binds LEF1 mRNA in a partly β-catenin dependent fashion, and may impact the post-transcriptional control of LEF-1 expression. Finally, we show that MSI2-mediated expansion of human HSPCs could be partly driven through LEF1 regulation. This is the first study to experimentally demonstrate functional crosstalk between MSI2 and Wnt signalling in human cells, and indicates potential novel post-transcriptional roles for β-catenin in a haematological context.
Comparative forecasting of adverse drug reaction trends among leprosy patients: Insights from the ARIMA and ETS models in a postpandemic context in a tertiary care center in Sri Lanka
Authors: Kahawita Indira Padmapani , Wijesinghe Millawage Supun Dilara , Karawita Upeksha Gayani , Nissanka Nissanka Achchi Kankanamalage Ayoma Iroshanee , Pathirage A.J , Lasanthi H.W.S , De Silva T.S.D , Thubellage D.S 
Published: February 2025

Abstract

Background
Adverse drug reactions (ADRs) in leprosy patients receiving multidrug therapy (MDT) present a persistent challenge, exacerbated by healthcare disruptions during the coronavirus disease 2019 (COVID-19) pandemic. Effective forecasting of ADR trends is essential for resource allocation and healthcare planning. This study analyzes ADR trends at Sri Lanka's Central Leprosy Clinic (CLC) from 2016–2023, uses the ARIMA and ETS models to predict future ADR counts and compares model performance.
Methods
A retrospective analysis of ADR data was conducted. Trends were assessed pre- and post-COVID-19, and forecasts for 2024–2030 were generated via the ARIMA and ETS models. Model performance was evaluated via the MAE, RMSE, AIC, and BIC. Statistical comparisons between periods were conducted via the Mann-Whitney U test.
Results
ADR counts increased significantly post-COVID-19, peaking at 46 in 2023. The ETS model outperformed the ARIMA model, with lower MAEs (0.84 vs. 8.00) and RMSEs (1.05 vs. 12.29). ETS forecasts indicated a steady rise in ADRs, reaching 32.33 by 2030, whereas ARIMA predictions showed greater variability. The Mann-Whitney U test confirmed significant differences between the pre- and post-COVID-19 periods (p = 0.03577).
Conclusion
The ETS model offers superior accuracy and stability for ADR trend forecasting, providing valuable insights for healthcare planning. These findings emphasize the need for robust ADR monitoring systems to address ongoing challenges in leprosy management, particularly in the postpandemic era.
Evaluation of sarcopenia in nonelderly patients with diabetes mellitus and its association with poor glycemic control
Authors: Daloglu Osman Onur , Unal Mehmet Cagri , Guller Pinar Uzgec , Alak Zehra Yagmur Sahin , Guclu Metin , Kiyici Sinem 
Published: February 2025

Abstract

Background
Sarcopenia is characterized by low muscle mass and strength, primarily affecting the elderly. It may also present in patients with type 2 diabetes mellitus (T2DM), especially those with poor glycemic control. This study aimed to evaluate the frequency of sarcopenia in nonelderly and overweight patients with T2DM and its association with glycemic control.
Methods
A total of 60 overweight patients with T2DM (mean duration 10 ± 1.3 years) were included to the study. Patients were classified into two groups according to their HbA1c levels. There were 30 patients (mean age 54 ± 5 years; 14 [46,6%] women) in poor glycemic control group (HbA1c > 7%) and 30 patients (mean age, 54 ± 6 years; 15[50%] women) in adequate glycemic control group (HbA1c ≤ 7). Hand grip strength (HGS) measurements using a dynamometer, skeletal muscle mass index (SMMI) measured by bioelectrical impedance analysis, 4-m walking test, and the Sarcopenia Quality of Life (SARQoL) and Pittsburgh Sleep Quality(PSQ) questionnaires were used to assess the presence of sarcopenia and QoL in all patients.
Results
Five patients (16.6%) in the poor glycemic control group were diagnosed with sarcopenia based on the assessment of muscle strength and mass. Among patients with adequate glycemic control, none met the criteria for sarcopenia. The median HGS and SMMI were significantly lower in patients with sarcopenia (15.4kg and 7.4kg/m2) than in patients with adequate glycemic control (29.8 kg and 10.6kg/m2; p = 0.021 and 0.006, respectively). There was a negative correlation between HbA1c and HGS in all patients (r = 0.424; p = 0.001). Multivariate linear regression analysis revealed that an increase in HbA1c leads to a decrease in SMMI (Beta: -0.293; 95% CI: -0.483 to -0.102; p = 0.003) and HGS (Beta: -2,016; 95% CI: -2,885 to -1,147; p = < 0.001). The SARQoL score was also significantly lower in patients with sarcopenia than the patients with adequate glycemic control (p = 0.022) while no significant difference was found in the PSQ score.
Conclusion
Sarcopenia may occur in nonelderly T2DM patients with poor glycemic control, leading to decreased QoL. Screening for sarcopenia should commence at a younger age if diabetes is uncontrolled and risk factors are present.
IL20RB promotes pancreatic cancer progression by activating NF- kB signalling and promoting EMT
Authors: Ruan Wanbai , Li Junfen , Yin Yanmei , Peng Lei , Zhu Kexiang 
Published: February 2025

Abstract

Purpose Currently, the pathogenesis and biological features of pancreatic cancer are not fully understood. Interleukin-20 receptor subunit beta (IL20RB) is a risk factor for poor prognosis in a variety of solid tumours, including breast cancer. However, the biological characteristics of IL20RB in pancreatic cancer and its impact on patient prognosis remain unclear. The aim of this study was to investigate the effect of IL20RB on the biological characteristics of pancreatic cancer and to explore the underlying mechanisms.
Methods The expression of IL20RB in pancreatic cancer and its effect on the prognosis of pancreatic cancer patients were analysed by The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. Immunohistochemistry and Western blot were used to detect IL20RB expression in pancreatic cancer tissues. Pancreatic cancer cell lines PANC-1 and BxPC-3 with stable knockdown of IL20RB were constructed.The effects of IL20RB on the proliferation, migration, apoptosis and cell cycle of pancreatic cancer cells were analysed by CCK-8 assay, plate clone formation assay, wound healing assay, Transwell assay and flow cytometry. Transcriptome sequencing analysis and Western blot were used to detect changes in NF-κB signalling and key molecules during EMT after IL20RB knockdown.
Results IL20RB is highly expressed in pancreatic cancer and that patients with high expression have a poor prognosis. Knockdown of IL20RB significantly inhibited the proliferation and migration of pancreatic cancer cells, induced cell apoptosis, and resulted in cell arrest in the S phase. Gene set enrichment analysis (GSEA) and transcriptome analysis showed that IL20RB regulated related signalling pathways in pancreatic cancer cells, including Nuclear factor-κb (NF-κB) and Epithelial-mesenchymal transition(EMT). After the knockdown of IL20RB, the expression of EMT-related protein E-cadherin was increased, and the expression of N-cadherin, Vimentin and Snail was decreased. At the same time, the expression levels of IKKα/β and P-NF-κB P65 were significantly reduced after IL20RB knockdown. The expression level of NF-κB P65 was not changed considerably, and the ratio of P-NF-κB P65/NF-κB P65 was significantly decreased.
Conclusion
IL20RB is highly expressed in pancreatic cancer and is associated with poor prognosis in patients. IL20RB may promote the proliferation, migration and apoptosis of pancreatic cancer cells by activating the IKKα/β/NF-κB P65 signalling pathway to promote the EMT process.
Sexually Transmitted Infections and Association with High-Risk Human Papillomavirus Among Ethiopian Women attending cervical cancer screening
Authors: Biazin Habtamu , Mekuria Selamawit , Assegid Nahom , Forslund Ola , Borgfeldt Christer , Jerkeman Mats , Mihret Adane , Abebe Tamrat 
Published: February 2025

Abstract

Introduction: Sexually transmitted infections (STIs) continue to be a major public health concern and threat on a global scale. This study aimed to determine the prevalence and association of STIs coinfection with hrHPV and histological findings in a cohort of women attending cervical cancer screening with self-sampling.
Method: This study was based on a cohort of 885 reproductive-aged women was attending cervical cancer screening at public prenatal care clinics in Adama, Ethiopia. The detection was performed by using the Allplex™ STI-EA real-time multiplex kit with the CFX96™ thermal cycler (Bio-Rad, CA, USA). The Seegene Anyplex II HPV HR test kit was used for the simultaneously detection of 14 hrHPV genotypes. Multivariable logistic regression analyses were made to test the association between the variables.
Result: Of all the study participants, 568 (64.2%) had at least one sexually transmitted microorganism (95% CI: 61-67). The overall prevalence of: Neisseria gonorrhea (NG) was 0.6% (95% CI: 0.2-1.5), Chlamydia trachomatis (CT) 1.4% (95% CI: 0.7-2.3), Trichomonas vaginalis (TV) 2.6% (95% CI: 1.6-3.8), Mycoplasma genitalium (MG) 2.3% (95% CI: 1.4-3.5), Mycoplasma hominis (MH) 19% (95% CI: 16-22), Ureaplasma urealyticum (UU) 23.2% (95% CI: 20.5-26.1), and Ureaplasma parvum (UP) 46.6% (95% CI: 43-50). The prevalence of NG, CT, and TV infection was 4.2% (37). There was correlation between CT (adjusted odds ratio (AOR)=5.4, 95% CI=1.4-21, p=0.014), MH (AOR=2.0, 95% CI= 1.4-3.0, p=0.001), HIV status (AOR=3.6, 95% CI= 2.0-6.6, P<0.001) with high-risk HPV infection. Hr-HPV infection was independently associated with histological abnormalities (AOR=14.8, 95% CI:1.1-19.9, p=0.043).
Conclusion:
Our study revealed a high prevalence of UU and MH in one out of five and UP in almost half of asymptomatic Ethiopian women. The prevalence of TV, MG, CT, and NG was low. There was a link between CT, MH, and HIV status and high-risk HPV infection. A high-risk-human papillomavirus and HIV infection was independently linked with histological abnormalities.
Traditional Complementary and Alternative Medicine (TCAM) for Cancer Related Conditions: Conflicts and Consensus
Authors: Mithunrosh Nayana , Nayar K Rajasekharan 
Published: February 2025

Abstract

Introduction:India accounts for 1.41 million cancer cases and conventional treatments remain standard. However, their side effects have led to increased interest in Traditional Complementary and Alternative Medicine (TCAM).
Objectives: This study explores TCAM usage patterns among cancer patients, examining their motivations, expectations, and experiences and analyze the consensus or disagreement between patients and Palliative Health Professionals (PHP) on integrating TCAM with conventional cancer treatments.
Methodology: A qualitative study design was adopted, utilizing semi-structured interviews with 21 cancer patients and 12 PHPs in Thrissur district, Kerala.
Results: The study revealed diverse patterns of TCAM usage and it highlighted both positive outcomes, such as symptom relief, enhanced immunity and improved quality of life, and negative experiences, including misdiagnosis, delayed treatment and aggravated conditions which led to reverting back to modern medicine. Non-disclosure of TCAM use to oncologists was common, complicating care integration.
Conclusions: The study highlights the complex landscape of TCAM utilization among cancer patients, emphasizing the need for balanced integration with conventional treatments. While TCAM offers potential benefits in enhancing patient well-being, concerns about safety, efficacy, must be addressed.