bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Removal of COD, NH3-N, and Turbidity from Sanitary Landfill Leachate using CB-PAC Particles: Isotherm Modelling and Treatment Assessment
Authors: OGEDEY Aysenur , OGUZ Ensar 
Published: January 2024

Abstract
This study aims to research the synchronous adsorption of COD, NH3-N, and turbidity from landfill leachate using coal-based powdered activated carbon (CB-PAC), examine its Langmuir adsorption capacities, and compare them to those of other commercial activated carbons. BET area and pore volume, FTIR spectra, SEM-EDX images, and zeta potential values of CB-PAC particles were investigated as well in order to comprehend the adsorption mechanism. Turbidity, NH3-N, and COD removal fit the Langmuir isotherm model due to their high correlation coefficients (R2 0.99, 0.98, and 0.99). The Langmuir capacities of CB-PAC particles for the concurrent adsorption of COD, NH3-N, and turbidity were revealed to be 500 mg O2/g, 17.5 mg/g, and 18 mg (NH2)2H2SO4/g. The optimum COD, NH3-N, and turbidity removal efficiencies at pH 5 were identified as 47.8%, 26.5%, and 51.8%, respectively. The CB-PAC particles' NH3-N and COD removal capacities were higher than other PAC particles reported in the literature. The strong adsorption capacities of the CB-PAC particles allow them to efficiently adsorb turbidity, NH3-N, and COD in the landfill leachate.
IoT Workload Offloading Efficient Intelligent Transport System in Federated ACNN Integrated Cooperated Edge-Cloud Networks
Authors: Lakhan Abdullah , Grønli Tor-Morten , Bellavista Paolo , Memon Sajida , Thinnukool Orawit , Alharby Maher 
Published: January 2024

Abstract
Intelligent transport systems (ITS) provide various cooperative edge cloud services for roadside vehicular applications. These applications offer additional diversity, including ticket validation across transport modes and vehicle and object detection to prevent road collisions. Offloading among cooperative edge and cloud networks plays a key role when these resources constrain devices (e.g., vehicles and mobile) to offload their workloads for execution. ITS used different machine learning and deep learning methods for decision automation. However, the self-autonomous decision-making processes of these techniques require significantly more time and higher accuracy for the aforementioned applications on the road-unit side.Thus, this paper presents the new offloading ITS for IoT vehicles in cooperative edge cloud networks. We present the augmented convolutional neural network (ACNN) that trains the workloads on different edge nodes. The ACNN allows users and machine learning methods to work together, making decisions for offloading and scheduling workload execution. This paper presents an augmented federated learning scheduling scheme (AFLSS). An algorithmic method called AFLSS comprises different sub-schemes that work together in the ITS paradigm for IoT applications in transportation. These sub-schemes include ACNN, offloading, scheduling, and security. Simulation results demonstrate that, in terms of accuracy and total time for the considered problem, the AFLSS outperforms all existing methods.
Human-computer interaction using artificial intelligence-based expert prioritization and neuro quantum fuzzy picture rough sets for identity management choices of non-fungible tokens in the Metaverse
Authors: Kou Gang , Dinçer Hasan , Pamucar Dragan , Yüksel Serhat , Deveci Muhammet , Olaru Gabriela Oana , Eti Serkan 
Published: January 2024

Abstract

Necessary improvements should be made to increase the effectiveness of non-fungible tokens on the Metaverse platform without having extra costs. For the purpose of handing this process more efficiently, there is a need to determine the most important factors for a more successful integration of non-fungible tokens into this platform. Accordingly, this study aims to determine the appropriate the identity management choices of non-fungible tokens in the Metaverse. There are three different stages in the proposed novel fuzzy decision-making model. The first stage includes prioritizing the expert choices with artificial intelligence-based decision-making methodology. Secondly, the criteria sets for managing non-fungible tokens are weighted by using Quantum picture fuzzy rough sets-based M-SWARA methodology. Finally, the identity management choices regarding non-fungible tokens in the Metaverse are ranked with Quantum picture fuzzy rough sets oriented VIKOR. The main contribution of this study is that artificial intelligence methodology is integrated to the fuzzy decision-making modelling to differentiate the experts. With the help of this situation, it can be possible to create clusters for the experts. Hence, the opinions of experts outside this group may be excluded from the scope. It has been determined that security must be ensured first to increase the use of non-fungible tokens on the Metaverse platform. Similarly, technological infrastructure must also be sufficient to achieve this objective. Moreover, biometrics for unique identification has the best ranking performance among the alternatives. Privacy with authentication plays also critical role for the effectiveness of this process.
Trends in malaria prevalence in the Jakiri Health District in Cameroon over a 16- year period (2006-2021): A retrospective study
Authors: Ndang Ndong Henry , Mengnjo Njodzela Christian , Masumbe Palmer Netongo , Chuye Ngala Hanson , Chu Chuo Ennestine , Enos Juliana Yartey , Amambua-Ngwa Alfred , Cheng Ndong Ignatius 
Published: January 2024

Abstract
Background
Malaria remains a serious public health concern, particularly in regions with favorable climatic conditions for transmission. The Jakiri Health District in the North-West Region of Cameroon is endemic to malaria, exhibiting significant burden and unique epidemiological characteristics. Understanding the dynamics of malaria prevalence in this district is vital for developing targeted interventions, optimizing resources, and guiding public health policies. We report the trends in malaria prevalence over a 16-year period in the Jakiri Health District, Cameroon.
Methods
Data was collected retrospectively through review of consultation, laboratory and prescription registers of the Jakiri District Hospital. Data was double entered, cross-checked, and analyzed using SPSS statistical software and Microsoft Excel.
Results
A total of 3,800 febrile patients were recorded from 2006 to 2021 with 2,318 (61.0%) being females and 1,482 (39.0%) males. A quarter of the patients (24.9%) were confirmed malaria positive. Malaria prevalence showed a fluctuating yet increasing pattern between 2006 and 2021. Confirmed malaria cases increased from 19.7% in 2006 through 21.3% in 2008 to 26.1% in 2009. Between 2009 and 2014, malaria cases dropped from 26.1–16.0%, then, increased steadily to a peak of 39.8% in 2019 and declined again to 24.8% in 2021. Malaria prevalence was higher in males (27.2%) than in females (23.0%), and the odds of having malaria were higher in males than in females (OR = 1.28, 95% CI 1.10–1.49). Of those tested, children aged 1 to < 5yrs and 5 to < 15 years were most affected by malaria during the study period.
Conclusion
Malaria prevalence was found to have increased in trend from 2006 to 2009, decreased during 2009 to 2014, and increased again from 2014 to 2019, with significant fluctuation across the study period. Children < 15 years remained the most vulnerable to malaria infection with males carrying the highest malaria burden in the locality. A shift in malaria burden from children under 5yrs to 5 to < 15yrs was observed during the period.
Induced senescence and calcification in anaplastic meningioma
Authors: Yokogami Kiyotaka , Watanabe Takashi , Yamashita Shinji , Mizuguchi Asako , Takeshima Hideo 
Published: January 2024

Abstract
Purpose. Meningiomas are the most common type of brain tumors and are generally benign, but malignant atypical meningiomas and anaplastic meningiomas frequently recur with poor prognosis. The metabolism of meningiomas is little known, so few effective treatment options other than surgery and radiation are available, and the targets for treatment of recurrence are not well defined. The Aim of this paper is to find the therapeutic target.
Methods. This study focused on meningioma metabolism and demonstrated that bone morphogenetic protein (BMP) signaling regulates meningioma growth, cellular senescence, and calcification.
Results. Inhibitors of BMP receptor (BMPR1A) and forced expression of Gremlin2 (GREM2) shifted tryptophan metabolism from kynurenine/quinolinic acid production to serotonin production in malignant meningiomas, reduced NAD+/NADH production, decreased gene cluster expression involved in oxidative phosphorylation, and caused decrease in ATP. Finally, malignant meningiomas underwent cellular senescence, decreased proliferation, and eventually formed psammoma bodies. We reanalyzed RNA-sequencing data of clinical samples obtained from GEO RNA-seq Experiments Interactive Navigator, a public database, and found that increased expression of GREM2 decreased the expression of genes involved in oxidative phosphorylation, similar to our experimental results.
Conclusions. The GREM2-BMPR1A-tryptophan metabolic pathway in meningiomas is a potential new therapeutic target.
Psychometric Evaluation of the German version of the Parent-Adolescent Communication Scale
Authors: Zapf Holger , Boettcher Johannes 
Published: January 2024

Abstract

Background: The quality of dyadic Parent-Child Communication (PCC) between parents and their adolescent children may be important for the adolescent’s general development and mental health during adolescence. Since German instruments for measuring PCC are still lacking, this study aimed to validate the German translation of the Parent-Adolescent Communication Scale (PACS), an internationally established self-report questionnaire.
Methods: To examine the theoretical-based two-factor model of the PACS in a German population sample of 1044 parent-adolescent dyads, confirmatory factor analyses were used. Moreover, the cross-group measurement invariance of the instrument was assessed. Two clinical samples were used to assess discriminative validity. Bland-Altman plots were used to asses parent-adolescent agreement.
Results: The two-factor structure of the PACS was supported. Scalar measurement invariance was established for parent age groups and adolescent gender but not for adolescent age groups and parent gender. Convergent and divergent validity were established. Discriminative validity was only established for the adolescent version in the adolescent psychiatry sample. Test-retest reliability was satisfactory, and rater agreement was medium.
Conclusion: The German translation of the PACS is a reliable and valid measurement to assess parent-adolescent communication quality per self-report. Research directions include the concordance discrepancy in clinical samples and further investigation of changes in parents’ and adolescents’ perspectives on problem and open communication.
Registration: NCT05332236 (clinicaltrials.gov), first registered 2022-04-11.
How do NMDA and AMPA receptors share a common regulatory mechanism that underlies the NMDAR-dependent LTP and LTD?
Authors: Li Yun-Qing , Huang Fensheng , Fan Bo-Yuan , Chen Ying-Biao , Li Hui , Zhao Tian-Yu , Li Meng-Ying , Bai Yang , Zhang Hua , Zhang Fu-Xing , Tang Jing-Shi , Wigstrom Holger 
Published: January 2024

Abstract
NMDA receptor (NMDAR)-dependent AMPA receptor (AMPAR)-mediated synaptic plasticity, encompassing long-term potentiation (LTP) and depression (LTD), is considered a cellular mechanism for learning and memory. However, the intertwined regulatory mechanisms of NMDAR and AMPAR-mediated synaptic plasticity are not yet fully understood. Here, we discovered that activating either NMDAR, AMPAR, or both leads to an activity-dependent synaptic depression, which is independent of Ca2+. Interestingly, even stimulating NMDAR at a test frequency of 0.1 Hz was able to induce LTP. Yet, this induction was impeded by antagonists of ryanodine receptors or CaMKII. We also observed that the activity-dependent synaptic depression is developmentally regulated and could be reversed by NMDAR-induced Ca2+-dependent upregulation. Furthermore, postsynaptic responses driven by both NMDAR and AMPAR displayed additive effects and synchronously shifted throughout the synaptic plasticity processes. This synchronous evolution indicates a shared regulatory mechanism. Based on previous studies and our current findings, it is suggested that a dynamic balance between activity-dependent dephosphorylation and CaMKII-dependent rephosphorylation of postsynaptic glutamate receptor functional sites guides the direction of NMDAR-dependent, AMPAR-mediated synaptic plasticity.
Analgesic efficacy and safety of regional anesthesia methods in the perioperative period of surgical treatment of unstable spinal fractures: a randomized study
Authors: Morunova A. Yu. , Ezhevskaya Anna A. 
Published: January 2024

INTRODUCTION: Perioperative anesthesia in spinal surgery is important areas of anesthesiology. Comparison of spine-straightening muscle block (Erector spinae plane block, ESP block) and epidural anesthesia (EA) during spinal surgery may access its effectiveness and safety. OBJECTIVE: To evaluate the efficacy and safety of a single and extended ESP block compared with epidural analgesia in the perioperative period of treatment of unstable vertebral fractures. MATERIALS AND METHODS: A prospective trial involved 110 patients. Three groups of patients were identified: group 1 (n = 35) — with bonuses P block; group 2 (n = 30) — with prolonged ESP block, group 3 (n = 45) — with prolonged epidural analgesia. Systemic hemodynamics, total opioid consumption, pain intensity, complications, the need for additional analgesia were evaluated. RESULTS: There were no differences in hemodynamics and opioid consumption in the intraoperative period. Six hours after surgery the groups with prolonged ESP block (group 2) and prolonged epidural analgesia (group 3) had lower pain indicators on the VAS scale than for group 1. The need for anesthesia (tramadol) for group 1 was significantly higher than for other groups, and amounted to 78 %. The need of opioid was 3 % for group 1, in other groups it was not required. PTR was present in a small percentage in each of the groups, but no statistical differences were found (p = 0.45). In the group with EA, there were 3 cases of urinary retention, 1 case of hip paresthesia. CONCLUSIONS: The use of ESP block allows to achieve effective and safe analgesia during spinal surgery for unstable vertebral fractures. Longer analgesia is provided by prolonged use of the ESP block than by its single use. When compared with prolonged EA, no significant differences were found in the effectiveness of analgesia, the consumption of opioids and the frequency of PTR.
Comment on the article of V.V. Antonova et al. “The effect of a tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate (Dalargin) on oxidative stress in patients with severe combined trauma: a prospective clinical study”
Authors: Grigoryev Evgeny V. 
Published: January 2024

Comment on the article of V.V. Antonova et al. “The effect of a tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate (Dalargin) on oxidative stress in patients with severe combined trauma: a prospective clinical study”
Comparative assessment of the prognostic ability of paediatric Sequential Organ Failure Assessment (pSOFA), paediatric logistic organ dysfunction 2 (PELOD 2) and Vasoactive-Inotropic Score (VIS) in children with septic shock: a retrospective observational study
Authors: Trembach А. V. , Bgane N. M. , Trembach I. A. , Mironov P. I. , Aleksandrovich Yuriy S. 
Published: January 2024

INTRODUCTION: Septic shock is the most severe stage of sepsis in children accompanied by a highest mortality. OBJECTIVE: The aim of the work is to compare an informative significance of pSOFA, PELOD 2 scales and VIS as predictors of mortality in children with septic shock. MATERIALS AND METHODS: The design of the study is retrospective, observational, single-center trial. The study was performed in the Children's Regional Clinical Hospital of Krasnodar. The inclusion criteria were children with septic shock from 9 months to 17 years old. The endpoint of trial was 28-day mortality. Demographic and clinical characteristic were presented with median and average values, also interquartile intervals were counted. Mann-Whitney U-test was used for comparison data received. The discriminatory power, sensitivity and specificity were defined with receiver operating characteristic (ROC) analysis and determination of area under ROC curve (AUC). RESULTS: No one of this trial’s score provides a prediction of children’s survival with sepsis and shock during first 24 hour PICU stay. PELOD 2 and pSOFA scores allow to estimate a prediction from day 3 from PICU stay. Furthermore PELOD 2 score shows a higher informative significance. The VIS has an ability to predict survival on day 5 from admission. CONCLUSIONS: Only the PELOD 2 score has a good discriminatory power regarding the prognosis of survival in children with septic shock after 48 hours of intensive care. The VIS scale allow to assess a severity of cardiovascular dysfunction in children with refractory septic shock with threshold critical value more than 21 points.
Rights of Investors as Participants in Relationships Related to the Creation and Use of Results of Intellectual Activity
Authors: Leontev K. B. 
Published: January 2024

Relevance. The article considers the problems caused by the limited possibilities of legal registration of relations between investors and persons creating the results of intellectual activity or organizing the creation of RIA. It is noted that the obligatory rights based on contracts concluded by investors do not allow to fully take into account their interests and provide guarantees of their observance when disposing of exclusive rights to the intellectual property created with the attraction of investment funds. The conclusions are substantiated that taking into account the growing needs in attracting investment funds for the implementation of projects related to the creation and use of RIAs, it is necessary to provide investors with the opportunity to participate in the ownership of exclusive rights to RIAs created with their support, which will allow investors to control the subsequent disposal of exclusive rights to such RIAs, directly participate in the licensing processes and receive remuneration for their use.The purpose is to develop theoretical provisions that form the basis for the development of legal regulation ensuring the observance of investors' rights as participants in relations related to the creation and use of RIA.Objectives: to identify the peculiarities of registration of investors' rights when they participate in relations related to the creation and use of RIA with the attraction of investment funds; to develop proposals aimed at improving the legal regulation of relations between investors, persons organizing the creation and use of RIA, authors and right holders for various cases of organization of investment activity in the field under consideration.Methodology. The dialectical-materialistic method, methods of analysis and synthesis, formal-legal method were used in writing the work.The results of the research are of theoretical and applied nature and are aimed at improving the quality of legal regulation of legal relations related to the creation and use of RIA.The conclusions made on the basis of the results of the conducted research have a discussion character and are aimed at improving the legal regulation of investment activities related to the creation of RIA. The article is a continuation of the author's scientific research.
Some Criminological Features of Crime in Migration Sphere
Authors: Novichkov V. E. 
Published: January 2024

Relevance. In recent years illegal migration also remains relevant, accompanied by criminal networks created by foreign citizens and stateless persons and the maintenance of an underground economy, including smuggling and illegal employment, which can cause social and economic problems. Compliance with legislation in the field of preventing and combating migrant crime helps maintain law-abiding and compliance with laws and regulations, as well as law and order and public safety in the country. The purpose of the study is to supplement scientific knowledge in terms of determining the general level of crime of foreigners and stateless persons in modern Russia, to identify factors that contribute to the commission of crimes by migrants. Objectives: to assess the current state (general level) of migration crime and compare it with the level among the local population; establish quantitative and qualitative characteristics of crime in the migration sphere; identify specific properties, as well as changes in crime in the migration sphere. Methodology. When writing a scientific article, general scientific methods related to universal methods were used: dialectical, historical, system-structural, generalization method and particular methods: extrapolation method, factor analysis, forecasting, document research, content analysis of the press, biographical and statistical.The results of the study made it possible to: determine the current level of crime among migrants in Russia and identify the main types of crimes that are most often committed by migrants; provide new comparative data on the crime of migrants in comparison with the general population of Russia and a number of regions; identify previously overlooked and new risk factors, as well as the socio-economic vulnerability of migrants. Conclusion. Modern Russian society is faced not only with large-scale migration processes, but also with qualitative and quantitative changes in crime in the migration sphere. This phenomenon signals a possible increase in the near future in the increased public danger of the acts of migrants, and if organizational and legal measures are not taken to neutralize this type of crime, then the trend of increasing crimes by foreign citizens and stateless persons will increase in the near future.