bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the usage of nut shell, walnut shell, and pistachio shell as a reinforcement particle on the mechanical and wear performance of polypropylene
Authors: Şahin Alp Eren , Fidan Sinan , Çetin Beysim , Sınmazçelik Tamer 
Published: February 2024

AbstractIn this study, the usability of nutshell, pistachio, and walnut shell wastes as reinforcement materials in industrial applications and their comparisons with each other was examined. For this purpose, composite samples with a polypropylene (PP) matrix were produced and their mechanical and tribological characterizations were performed. As a result of the tensile tests, both the tensile strength and elastic modulus values of all composite specimens are higher than those of pure PP. On the other hand, the value of elongation at break is lower. The sliding wear resistance increases with increasing reinforcement with walnut and pistachio shell reinforcement, whereas the positive effect becomes negative when the nutshell reinforcement is over 3 wt%. All three types of reinforcement positively affected the scratch resistance. Pistachio shell reinforcement gives the best result. It has been determined that the relative cutting volume value of the samples increases with the reinforcement rate and the wear behavior changes from ductile to brittle. In light of these results, it has been seen that nut, pistachio, and walnut shells could be used as reinforcement materials in industrial applications instead of being waste or fuel.
Effects of styrene–acrylic emulsion on bond performance and interface microstructure of repair mortar of ternary cementitious system
Authors: Shi Chen , Bu Kaiyin , Ma Chenyuan 
Published: February 2024

AbstractThis study investigates the effects of styrene–acrylic emulsion (SAE) as a modifier and interfacial agent on the interfacial bond performance of ordinary Portland cement–aluminate cement–gypsum (PAG) repair mortar. The hydration products and interfacial microstructure are analyzed via x‐ray diffraction (XRD), x‐ray photoelectron spectroscopy (XPS), Fourier‐transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). The results demonstrate that the addition of SAE can effectively enhance the tensile bond strength and flexural bond strength of the PAG repair mortar, and the optimal addition amount of SAE is 10 wt%. The tensile and flexural bond strengths of the PAG repair mortar with SAE interfacial agent at 40% concentration are 1.38 and 1.34 times than those of the mortar without the interfacial agent, respectively. XPS and FTIR analyses reveal that the carboxyl groups in SAE and Ca2+ generated from cement hydration form Ca2+–carboxyl complexes. The SEM and XRD analyses indicate that SAE can alter the distribution and size of crystals at the bond interface and considerably reduce the thickness of the bond interface; however, SAE cannot change the type of hydration products at the bond interface.
Quinazoline‐chalcone hybrids as HDAC/EGFR dual inhibitors: Design, synthesis, mechanistic, and in‐silico studies of potential anticancer activity against multiple myeloma
Authors: Mansour Mostafa A. , AboulMagd Asmaa M. , Abbas Samar H. , Abdel‐Aziz Mohamed , Abdel‐Rahman Hamdy M. 
Published: February 2024

AbstractTwo new series of quinazoline‐chalcone hybrids were designed, synthesized as histone deacetylase (HDAC)/epidermal growth factor receptor (EGFR) dual inhibitors, and screened in vitro against the NCI 60 human cancer cell line panel. The most potent derivative, compound 5e bearing a 3,4,5‐trimethoxyphenyl chalcone moiety, showed the most effective growth inhibition value against the panel of NCI 60 human cancer cell lines. Thus, it was selected for further investigation for NCI 5 log doses. Interestingly, this trimethoxy‐substituted analog inhibited the proliferation of Roswell Park Memorial Institute (RPMI)‐8226 cells by 96%, at 10 µM with IC50 = 9.09 ± 0.34 µM and selectivity index = 7.19 against normal blood cells. To confirm the selectivity of this compound, it was evaluated against a panel of tyrosine kinase enzymes. Mechanistically, it successfully and selectively inhibited HDAC6, HDAC8, and EGFR with IC50 = 0.41 ± 0.015, 0.61 ± 0.027, and 0.09 ± 0.004 µM, respectively. Furthermore, the selected derivative induced apoptosis via the mitochondrial apoptotic pathway by raising the Bax/Bcl‐2 ratio and activating caspases 3, 7, and 9. Also, the flow cytometry analysis of RPMI‐8226 cells showed that the trimethoxy‐substituted analog produced cell cycle arrest in the G1 and S phases at 55.82%. Finally, an in silico study was performed to explore the binding interaction of the most active compound within the zinc‐containing binding site of HDAC6 and HDAC8.
Determination of omeprazole via fluorescence‐quenching methodology; application to content uniformity testing
Authors: Elmansi Heba , Orbano Asya , Mashkour Maram , Shamiya Heba Abo , Belal Fathalla 
Published: February 2024

AbstractA new, proven, economical spectrofluorimetric approach has been used to determine the proton pump inhibitor omeprazole (OMP). This innovative technique is based on the ability of OMP to quench the native fluorescence of the mercurochrome dye in an acidic (pH 3.6) solution. Because it was discovered that quenching is proportional to the drug concentration, this dye was used as a sensor for OMP detection. The fluorescence intensity was measured at 518/540 nm, and its linear response ranged from 0.2–10.0 μg/mL with a linear coefficient of 0.9999. The computation yielded a limit of quantification (LOQ) of 0.20 μg/mL and a limit of detection (LOD) of 0.07 μg/mL. Every circumstance and element impacting the reaction product was examined in detail. Pharmacopeial standards carried out the validation. The approved method investigated several commercial preparations and formulations, and the results were favorably compared with those provided by a reference method. According to United States Pharmacopeia (USP) rules, content consistency for two distinct formulations was evaluated.
Anatomy of the chimera: Environmental, Social, and Governance ratings beyond the myth
Authors: Lucarelli Caterina , Severini Sabrina 
Published: February 2024

AbstractEnvironmental, Social, and Governance (ESG) ratings were developed to account for the multidimensional nature of the sustainability of firms. Research on ESG ratings suggests that working towards sustainability means engaging in a utopian effort, as in the chimera myth. We developed a conceptual framework of corporate activities that guides a systematic literature review based on 79 papers. Our analysis confirms that ESG ratings remain a black box, explored mainly from a purely monetary perspective and with contradictions on value created for companies and collective well‐being. Therefore, we deduce that research is still “chasing a chimera,” being this incomplete knowledge due to divergences in (1) theories, (2) regulations, (3) geographic and (4) corporate culture, (5) constructs/metrics, and (6) corporate attitude towards disclosure. Consequently, we identify research gaps and avenues for future research to foster corporations' responsible behaviours and socially responsible investing.
RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions
Authors: Javid Hossein , Oryani Mahsa Akbari , Rezagholinejad Nastaran , Esparham Ali , Tajaldini Mahboubeh , Karimi‐Shahri Mehdi 
Published: February 2024

AbstractRGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in biotechnology and medicine, including incorporation into biomaterials, conjugation to medicinal molecules or nanoparticles, and labeling with imaging agents. RGD peptides can be utilized to specifically target cancer cells and the tumor vasculature by engaging with these integrins, improving drug delivery efficiency and minimizing adverse effects on healthy tissues. RGD‐functionalized drug carriers are a viable option for cancer therapy as this focused approach has demonstrated promise in the future. Writing a review on the RGD peptide can significantly influence how drugs are developed in the future by improving our understanding of the peptide, finding knowledge gaps, fostering innovation, and making drug design easier.
Assessment of salivary cadmium levels and breast density in the Marin Women's Study
Authors: George Michaela F. , Paff Shayne , Rojo Jenyse , Powell Mark , Benz Christopher , Pope Karl , Kerlikowske Karla , Shepard John , Willis Matthew , Ereman Rochelle , Prebil LeeAnn 
Published: February 2024

AbstractBackgroundWe aimed to determine if salivary cadmium (Cd) levels had any association with breast density, hoping to establish a less invasive cost‐effective method of stratifying Cd burden as an environmental breast cancer risk factor.MethodsSalivary Cd levels were quantified from the Marin Women's Study, a Marin County, California population composite. Volumetric compositional breast density (BDsxa) data were measured by single x‐ray absorptiometry techniques. Digital screening mammography was performed by the San Francisco Mammography Registry. Radiologists reviewed mammograms and assigned a Breast Imaging‐Reporting and Data System score. Early morning salivary Cd samples were assayed. Association analyses were then performed.ResultsCd was quantifiable in over 90% of saliva samples (mean = 55.7 pg/L, SD = 29). Women with higher saliva Cd levels had a non‐significant odds ratio of 1.34 with BI‐RAD scores (3 or 4) (95% CI 0.75–2.39, p = 0.329). Cd levels were higher in current smokers (mean = 61.4 pg/L, SD = 34.8) than former smokers or non‐smokers. These results were non‐significant. Pilot data revealed that higher age and higher BMI were associated with higher BI‐RAD scores (p < 0.001).ConclusionSalivary Cd is a viable quantification source in large epidemiologic studies. Association analyses between Cd levels and breast density may provide additional information for breast cancer risk assessment, risk reduction plans, and future research directions. Further work is needed to demonstrate a more robust testing protocol before the extent of its usefulness can be established.
The exo‐microRNA (miRNA) signaling pathways in pathogenesis and treatment of stroke diseases: Emphasize on mesenchymal stem cells (MSCs)
Authors: Farahmand Yalda , Nabiuni Mohsen , Vafaei Mastanabad Mahsa , Sheibani Mehrnaz , Mahmood Bashar Shaker , Obayes Ali Mohammed , Asadi Fatemeh , Davallou Rosa 
Published: February 2024

AbstractA major factor in long‐term impairment is stroke. Patients with persistent stroke and severe functional disabilities have few therapy choices. Long noncoding RNAs (lncRNAs) may contribute to the regulation of the pathophysiologic processes of ischemic stroke as shown by altered expression of lncRNAs and microRNA (miRNAs) in blood samples of acute ischemic stroke patients. On the other hand, multipotent mesenchymal stem cells (MSCs) increase neurogenesis, and angiogenesis, dampen neuroinflammation, and boost brain plasticity to improve functional recovery in experimental stroke models. MSCs can be procured from various sources such as the bone marrow, adipose tissue, and peripheral blood. Under the proper circumstances, MSCs can differentiate into a variety of mature cells, including neurons, astrocytes, and oligodendrocytes. Accordingly, the capability of MSCs to exert neuroprotection and also neurogenesis has recently attracted more attention. Nowadays, lncRNAs and miRNAs derived from MSCs have opened new avenues to alleviate stroke symptoms. Accordingly, in this review article, we examined various studies concerning the lncRNAs and miRNAs' role in stroke pathogenesis and delivered an overview of the therapeutic role of MSC‐derived miRNAs and lncRNAs in stroke conditions.
Endoscopic view of the vertebra during laser balloon ablation of paroxysmal atrial fibrillation
Authors: Sasaki Shun , Shibuya Yuki , Minamiguchi Hitoshi , Sakio Takashige , Hamanaka Yuma , Kanda Takashi , Ichibori Yasuhiro , Makino Nobuhiko , Hirayama Atsushi , Higuchi Yoshiharu 
Published: February 2024

Key Clinical MessageLeft atrial posterior wall on the vertebra is often difficult to obtain stable tissue contact with ablation‐catheter. Laser balloon ablation is effective because the compression from the vertebra can be visualized through endoscopy.AbstractWhen performing pulmonary vein isolation (PVI) with radiofrequency, left atrial posterior wall on the vertebra is often difficult to obtain stable tissue contact with ablation‐catheter because of the movement of the ablation point. Laser balloon ablation is effective for the achievement of durable PVI in cases with such anatomical characteristics because the compression from the vertebra can be visualized through endoscopy.
MnFeNi‐Based Composite as a Case Study of a Bifunctional Oxygen Electrocatalyst under Dynamically Changing Electrode Potentials
Authors: Morales Dulce M. , Kazakova Mariya A. , Medina Danea , Villalobos Javier , Schuck Götz , Risch Marcel , Schuhmann Wolfgang 
Published: February 2024

AbstractHigh‐performance bifunctional electrocatalysts for the oxygen reduction (ORR) and oxygen evolution reaction (OER) are essential components in energy conversion and storage technologies. Yet, their poor reversibility hinders their applicability. A highly active ORR/OER catalyst, consisting of multiwalled carbon nanotubes‐supported MnFeNiOx nanoparticles, was subjected to sequences of chronoamperometric steps alternating between the ORR, the OER and highly cathodic potentials (Ec). Rotating ring disk electrode methods revealed that applying Ec leads to a small increase in the current and peroxide species yield during the ORR while enhancing substantially the OER. X‐ray absorption spectroscopy showed irreversible changes in the chemical state of MnFeNiOx correlating with its catalytic properties. The complexity of changes that a composite catalyst may undergo under varying potentials, the importance of monitoring product formation, and the convenience of using dynamic electrochemical sequences for the assessment of catalyst reversibility, as well as for the activation and/or restoration of their catalytic properties, are highlighted.
Interpenetrating network‐reinforced gel polymer electrolyte for ultra‐stable lithium−iodine batteries
Authors: Jiang Ying , Huang Peng , Tong Minman , Qi Bingxin , Sun Tao , Xian Zhongyun , Yan Wen , Lai Chao 
Published: February 2024

AbstractLi−I2 batteries have attracted much interest due to their high capacity, exceptional rate performance, and low cost. Even so, the problems of unstable Li anode/electrolyte interface and severe polyiodide shuttle in Li−I2 batteries need to be tackled. Herein, the interfacial reactions on the Li anode and I2 cathode have been effectively optimized by employing a well‐designed gel polymer electrolyte strengthened by cross‐linked Ti–O/Si–O (GPETS). The interpenetrating network‐reinforced GPETS with high ionic conductivity (1.88 × 10−3 S cm−1 at 25°C) and high mechanical strength endows uniform Li deposition/stripping over 1800 h (at 1.0 mA cm−2, with a plating capacity of 3.0 mAh cm−2). Moreover, the GPETS abundant in surface hydroxyls is capable of capturing soluble polyiodides at the interface and accelerating their conversion kinetics, thus synergistically mitigating the shuttle effect. Benefiting from these properties, the use of GPETS results in a high capacity of 207 mAh g−1 (1 C) and an ultra‐low fading rate of 0.013% per cycle over 2000 cycles (5 C). The current study provides new insights into advanced electrolytes for Li−I2 batteries.
Facilitating prelithiation of silicon carbon anode by localized high‐concentration electrolyte for high‐rate and long‐cycle lithium storage
Authors: Zhang Yuanxing , Wu Borong , Bi Jiaying , Zhang Xinyu , Mu Daobin , Zhang Xin‐Yu , Zhang Ling , Xiao Yao , Wu Feng 
Published: February 2024

AbstractThe commercialization of silicon‐based anodes is affected by their low initial Coulombic efficiency (ICE) and capacity decay, which are attributed to the formation of an unstable solid electrolyte interface (SEI) layer. Herein, a feasible and cost‐effective prelithiation method under a localized high‐concentration electrolyte system (LHCE) for the silicon–silica/graphite (Si–SiO2/C@G) anode is designed for stabilizing the SEI layer and enhancing the ICE. The thin SiO2/C layers with –NH2 groups covered on nano‐Si surfaces are demonstrated to be beneficial to the prelithiation process by density functional theory calculations and electrochemical performance. The SEI formed under LHCE is proven to be rich in ionic conductivity, inorganic substances, and flexible organic products. Thus, faster Li+ transportation across the SEI further enhances the prelithiation effect and the rate performance of Si–SiO2/C@G anodes. LHCE also leads to uniform decomposition and high stability of the SEI with abundant organic components. As a result, the prepared anode shows a high reversible specific capacity of 937.5 mAh g−1 after 400 cycles at a current density of 1 C. NCM 811‖Li‐SSG‐LHCE full cell achieves a high‐capacity retention of 126.15 mAh g−1 at 1 C over 750 cycles with 84.82% ICE, indicating the great value of this strategy for Si‐based anodes in large‐scale applications.
Comparison of outcomes for Hispanic and non‐Hispanic patients with advanced renal cell carcinoma in the International Metastatic Renal Cell Carcinoma Database
Authors: Guram Kripa , Huang Jiaming , Mouchati Christian , Abdallah Nour , Jani Chinmay , Navani Vishal , Xie Wanling , El Zarif Talal , Adib Elio , Gebrael Georges , Agarwal Neeraj , Li Haoran , Labaki Chris , Labban Muhieddine , Ruiz Morales Jose Manuel , Choueiri Toni K. , Chin Heng Daniel Yick , Mittal Abhenil , Hansen Aaron R. , Rose Brent S. , McKay Rana R. 
Published: February 2024

AbstractBackgroundExisting data on the impact of Hispanic ethnicity on outcomes for patients with renal cell carcinoma (RCC) is mixed. The authors investigated outcomes of Hispanic and non‐Hispanic White (NHW) patients with advanced RCC receiving systemic therapy at large academic cancer centers using the International Metastatic Renal Cell Carcinoma Database (IMDC).MethodsEligible patients included non‐Black Hispanic and NHW patients with locally advanced or metastatic RCC initiating systemic therapy. Overall survival (OS) and time to first‐line treatment failure (TTF) were calculated using the Kaplan–Meier method. The effect of ethnicity on OS and TTF were estimated by Cox regression hazard ratios (HRs).ResultsA total of 1563 patients (181 Hispanic and 1382 NHW) (mostly males [73.8%] with clear cell RCC [81.5%] treated with tyrosine kinase inhibitor [TKI] monotherapy [69.9%]) were included. IMDC risk groups were similar between groups. Hispanic patients were younger at initial diagnosis (median 57 vs. 59 years, p = .015) and less likely to have greater than one metastatic site (60.8% vs. 76.8%, p < .001) or bone metastases (23.8% vs. 33.4%, p = .009). Median OS and TTF was 38.0 months (95% confidence interval [CI], 28.1–59.2) versus 35.7 months (95% CI, 31.9–39.2) and 7.8 months (95% CI, 6.2–9.0) versus 7.5 months (95% CI, 6.9–8.1), respectively, in Hispanic versus NHW patients. In multivariable Cox regression analysis, no statistically significant differences were observed in OS (adjusted hazard ratio [HR], 1.07; 95% CI, 0.86–1.31, p = .56) or TTF (adjusted HR, 1.06; 95% CI, 0.89–1.26, p = .50).ConclusionsThe authors did not observe statistically significant differences in OS or TTF between Hispanic and NHW patients with advanced RCC. Receiving treatment at tertiary cancer centers may mitigate observed disparities in cancer outcomes.
Effect of π–π Interactions on Morphology of Nonplanar Binary Halogen‐Bonded Cocrystals
Authors: Zheng Yuqi , Qu Zhao , Wu Yichao , Wang Zilong , Tang Zhenxun , Wen Tao , Ji Zhuoyu 
Published: February 2024

AbstractThe application of organic crystal in different photoelectric device has different demand on the crystal structure and morphology, while the self‐assembly of different materials into crystals with a desired morphology remains a challenge. Herein, using three binary halogen‐bonded cocrystals involving a nonplanar halogen accepter molecule tetra(4‐pyridyl)‐tetrathiafulvalene (TTF(py)4), co‐crystallized with halogen donor aryl iodides C6F6‐xIx (x = 2,3, 1,3,5‐trifluoro‐2,4,6‐triiodobenzene (IFB), meta‐1,3‐diiodotetrafluorobenzene (mdIFB) or para‐1,3‐diiodotetrafluorobenzene (pdIFB)), are reported. TTF(py)4‐IFB cocrystals are formed primarily via N···I halogen bonds and F···H hydrogen bonds, while TTF(py)4‐mdIFB cocrystals and TTF(py)4‐pdIFB cocrystals are formed primarily via π–π Interactions, N···I halogen bonds and F···H hydrogen bonds, homogeneous π–π interactions are dominant in TTF(py)4‐mdIFB, while heterogeneous π–π interactions are dominant in TTF(py)4‐pdIFB. Through predicted morphology based on the attachment energy (Eatt) theory, especially π–π interaction, the influence of intermolecular interactions on crystal morphology is analyzed. The study demonstrates that the π–π interaction plays an important role in regulating the crystal structure and morphology, the work provides a deeper understanding of π–π interactions in nonplanar binary halogen‐bonded cocrystals.
A retrospective study on the prognostic factors and success, survival, and failure outcomes of treated endodontic‐periodontal lesions
Authors: Wong Ingar , Ton An , Cassidy Amiel J. , Fozzard Nicolette , Sharma Lavanya Ajay , Love Robert M. , Sharma Ajay 
Published: February 2024

AbstractObjectivesThe objective of this retrospective study was to determine possible prognostic factors of endodontic‐periodontal lesions and to compare success, survival, and failure outcomes of treated endodontic‐periodontal lesions across different treatment modalities, demographic variables, and anatomical tooth variations.Materials and MethodsData was collected from patient records in the patient management system (Salud, Titanium Solutions) from the Griffith University Dental Clinic between January 2008 and December 2021. The search strategy used the terms “endodontic periodontal lesion,” “periodontal endodontic lesion,” “endo perio lesion,” “perio endo lesion,” and “EPL.” The 88 cases which met inclusion and exclusion criteria were analyzed.ResultsThe overall success rate was 46.6%, with 21.6% of teeth surviving and 31.8% of teeth failing. Bone loss extending to the apical third (OR = 0.3, 95% CI [0.104, 0.866]), and probing depths of 5–7 mm (OR = 0.147, 95% CI [0.034, 0.633]) and 8‐10 mm (OR = 0.126, 95% CI [0.029, 0.542]) were associated with a statistically significant lower odds of success (p < .05). A history of no periodontal disease (OR = 7.705, 95% CI [1.603, 37.037]) was associated with a statistically significant higher odds of success (p < .05).ConclusionPractitioners should be aware of bone loss to the apical third, deep probing depths, and a history of periodontal disease as possible prognostic factors that can affect the success rate when treating endodontic‐periodontal lesions. Further research with more stringent control over operator factors should be done to investigate these variables.