bluuebunny/crossref_metadata_2025_split huggingface dataset:
Winter snow cover influences growing-season vegetation productivity non-uniformly in the Northern Hemisphere
Authors: Liu Hao , Xiao Pengfeng , Zhang Xueliang , Chen Siyong , Wang Yunhan , Wang Wenye 
Published: December 2023

AbstractOngoing changes in snow cover significantly affect vegetation productivity, but the actual effect of snow cover remains unclear due to a poor understanding of its lagged effect. Here, we used multisource datasets to investigate the lagged effect of snow cover on vegetation productivity in Northern Hemisphere ( > 40°N) ecosystems from 2000 to 2018. We found a widespread lagged effect of snow cover ( > 40%, P < 0.05) on growing season vegetation productivity (mean ~73-day lag). The effect of snow cover on vegetation productivity was underestimated by over 10% of the areas without considering regional lagged time differences. A longer lagged effect generally occurred in warm and humid areas, and areas with increased lagged time (66%) were greater than those with decreased trends. Moreover, changes in lagged effect were strongly driven by climate factors, followed by soil and topography factors. These findings emphasize the need to consider lagged time differences of snow cover when investigating snow-vegetation productivity interactions.
Concurrent gliomas in patients with multiple sclerosis
Authors: Sahm Katharina , Kessler Tobias , Eisele Philipp , Ratliff Miriam , Sperk Elena , König Laila , Breckwoldt Michael O. , Seliger Corinna , Mildenberger Iris , Schrimpf Daniel , Herold-Mende Christel , Zeiner Pia S. , Tabatabai Ghazaleh , Meuth Sven G. , Capper David , Bendszus Martin , von Deimling Andreas , Wick Wolfgang , Sahm Felix , Platten Michael 
Published: December 2023

Abstract
Background
Concurrent malignant brain tumors in patients with multiple sclerosis (MS) constitute a rare but paradigmatic phenomenon for studying neuroimmunological mechanisms from both molecular and clinical perspectives.

Methods
A multicenter cohort of 26 patients diagnosed with both primary brain tumors and multiple sclerosis was studied for disease localization, tumor treatment-related MS activity, and molecular characteristics specific for diffuse glioma in MS patients.

Results
MS neither predisposes nor protects from the development of gliomas. Patients with glioblastoma WHO grade 4 without isocitratdehydrogenase (IDH) mutations have a longstanding history of MS, whereas patients diagnosed with IDH-mutant astrocytoma WHO grade 2 receive multiple sclerosis diagnosis mostly at the same time or later. Concurrent MS is associated with a lesser extent of tumor resection and a worse prognosis in IDH-mutant glioma patients (PFS 32 vs. 64 months, p = 0.0206). When assessing tumor-intrinsic differences no distinct subgroup-defining methylation pattern is identified in gliomas of MS patients compared to other glioma samples. However, differential methylation of immune-related genetic loci including human leukocyte antigen locus on 6p21 and interleukin locus on 5q31 is found in MS patients vs. matched non-MS patients. In line, inflammatory disease activity increases in 42% of multiple sclerosis patients after brain tumor radiotherapy suggesting a susceptibility of multiple sclerosis brain tissue to pro-inflammatory stimuli such as ionizing radiation.

Conclusions
Concurrent low-grade gliomas should be considered in multiple sclerosis patients with slowly progressive, expansive T2/FLAIR lesions. Our findings of typically reduced extent of resection in MS patients and increased MS activity after radiation may inform future treatment decisions.
Specific topics, specific symptoms: linking the content of recurrent involuntary memories to mental health using computational text analysis
Authors: Yeung Ryan C. , Fernandes Myra A. 
Published: December 2023

AbstractResearchers debate whether recurrent involuntary autobiographical memories (IAMs; memories of one’s personal past retrieved unintentionally and repetitively) are pathological or ordinary. While some argue that these memories contribute to clinical disorders, recurrent IAMs are also common in everyday life. Here, we examined how the content of recurrent IAMs might distinguish between those that are maladaptive (related to worse mental health) versus benign (unrelated to mental health). Over two years, 6187 undergraduates completed online surveys about recurrent IAMs; those who experienced recurrent IAMs within the past year were asked to describe their memories, resulting in 3624 text descriptions. Using a previously validated computational approach (structural topic modeling), we identified coherent topics (e.g., “Conversations”, “Experiences with family members”) in recurrent IAMs. Specific topics (e.g., “Negative past relationships”, “Abuse and trauma”) were uniquely related to symptoms of mental health disorders (e.g., depression, PTSD), above and beyond the self-reported valence of these memories. Importantly, we also found that content in recurrent IAMs was distinct across symptom types (e.g., “Communication and miscommunication” was related to social anxiety, but not symptoms of other disorders), suggesting that while negative recurrent IAMs are transdiagnostic, their content remains unique across different types of mental health concerns. Our work shows that topics in recurrent IAMs—and their links to mental health—are identifiable, distinguishable, and quantifiable.
Emotional event perception is related to lexical complexity and emotion knowledge
Authors: Li Zhimeng , Lu Hanxiao , Liu Di , Yu Alessandra N. C. , Gendron Maria 
Published: December 2023

AbstractInferring emotion is a critical skill that supports social functioning. Emotion inferences are typically studied in simplistic paradigms by asking people to categorize isolated and static cues like frowning faces. Yet emotions are complex events that unfold over time. Here, across three samples (Study 1 N = 222; Study 2 N = 261; Study 3 N = 101), we present the Emotion Segmentation Paradigm to examine inferences about complex emotional events by extending cognitive paradigms examining event perception. Participants were asked to indicate when there were changes in the emotions of target individuals within continuous streams of activity in narrative film (Study 1) and documentary clips (Study 2, preregistered, and Study 3 test-retest sample). This Emotion Segmentation Paradigm revealed robust and reliable individual differences across multiple metrics. We also tested the constructionist prediction that emotion labels constrain emotion inference, which is traditionally studied by introducing emotion labels. We demonstrate that individual differences in active emotion vocabulary (i.e., readily accessible emotion words) correlate with emotion segmentation performance.
Kinderlungenregister (chILD-EU) – Zusammenarbeit
führt zu Fortschritten bei den seltenen und interstitiellen
Lungenerkrankungen
Authors: Griese Matthias , Gold Angelika , Gothe Florian , Kaiser Hannah , Kammer Birgit , Kappler Matthias , Krueger-Stollfuss Ingrid , Ley-Zaporozhan Julia , Michel Katarzyna , Rapp Christina K , Reu-Hofer Simone , Rock Hans , Schams Andrea , Tran Nguyen-Binh , Schwerk Nicolaus 
Published: December 2023

Zusammenfassung
Hintergrund Fortschritte bei den seltenen und interstitiellen
Lungenerkrankungen im Kindesalter können am effizientesten durch eine
systematische, registerbasierte Sammlung erzielt werden.
Fragestellung und Methode Wie sind die praktischen Abläufe und der
Nutzen einer Teilnahme am Kinderlungenregister/chILD-EU-Projekt? Wir
berichten unsere klinischen Erfahrungen.
Ergebnisse Kinderärzte und pädiatrische Pneumologen
identifizieren Kindern mit seltenen Lungenerkrankungen. Diese werden nach
Zustimmung der Eltern an das Kinderlungenregister gemeldet. Dazu werden
klinische Daten, Bildgebung und Blut an das Register gesendet. Bei Wunsch
können genetische Analysen veranlasst werden. Mit
Vollständigkeit der Daten erfolgt ein Peer-review Prozess durch
kinderradiologische, ggf lungenpathologische, klinische und ggf genetische
Experten in einer interdisziplinären Konferenz. Eine Arbeitsdiagnose
wird erstellt und dem zuständigen Arzt über das Register
mitgeteilt und ggf. in fallbezogenen Diskussionen weiter besprochen.
Hilfestellung bei der Eingabe der Daten erfolgt von Registerseite.
Verlaufsbeobachtungen erfolgen jährlich, alle im Register angemeldeten
Ärzte werden zu regelmäßigen, web-basierten
Falldiskussionen eingeladen. In wissenschaftlichen Projekten werden bedeutsame
Fragestellungen beantwortet und gemeinsam publiziert (>110 Publikationen
bisher).
Schlussfolgerungen Durch freiwilliges Engagement aller Beteiligten
über die klinische Routineversorgung hinaus, konnten bisher mehr als
1000 Kinder mit seltenen Lungenerkrankungen in das Register mit Biobank
eingeschlossen werden. Ein tieferes Verständnis der klinischen
Verläufe großer Kohorten seltener Erkrankungen und die
Erstbeschreibung neuer Entitäten trägt zu einer besseren
Versorgung dieser Kinder bei.
Impact of Reanalysis of Nitrogen Multiple-Breath Washout on its
Relationship with Chest Magnetic Resonance Imaging Findings in Clinically Stable
and Pulmonary Exacerbated Children with Cystic Fibrosis
Authors: Meißner Maria , Steinke Eva , Wielpütz Mark Oliver , Joachim Cornelia , Sommerburg Olaf , Mall Marcus Alexander , Stahl Mirjam 
Published: December 2023

Abstract
Rationale Multiple-breath washout (MBW)-derived lung clearance index (LCI)
detects lung disease in children with cystic fibrosis (CF). Correction of a
cross-talk error in the software of the MBW device Exhalyzer D in a new software
version has generated significant interest regarding its impact on previous MBW
findings. Since LCI and chest magnetic resonance imaging (MRI) correlated before
in CF children, this study aims to reassess previous MBW data after
correction.
Patients/Methods Reanalysis of the main findings from a previously
published study comparing MBW and MRI in a pediatric CF cohort by reassessment
of nitrogen (N2) MBW of 61 stable children with CF, 75 age-matched
healthy controls (HC), and 15 CF children with pulmonary exacerbation (PEx) in
the corrected software version.
Results The corrected LCI (N2LCIcor) decreased in
the entire cohort (−17.0 (11.2)%), HC (−8.5
(8.2)%), stable CF children (−22.2 (11.1)%), and within
the PEx group at baseline, at PEx and after antibiotic therapy (−21.5
(7.3)%; −22.5 (6.1)%; −21.4 (6.6)%; all
P<0.01). N2LCIcor and
N2LCIpre correlated with chest MRI scores in stable CF
(r=0.70 to 0.84; all P<0.01) without a significant difference
between N2LCIcor and N2LCIpre.
Change in LCI from baseline to PEx and from PEx to after therapy decreased from
N2LCIpre to N2LCIcor, but these
changes remained significant (all P=0.001).
Discussion/Conclusions Our results indicate that
N2LCIcor is significantly lower than
N2LCIpre, but key results published in the original
study demonstrating N2MBW and MRI as complementary methods for
clinical surveillance in children with CF remain unaffected.
Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease: A systematic review and meta-analysis
Authors: Niu Chengu , Zhang Jing , Iyer Charoo , Saeed Hasaan , Zhu kaiwen , Elkhapery Ahmed , Okolo Patrick I 
Published: December 2023

Abstract
Background and study aims Gastroesophageal reflux disease (GERD) is a widespread chronic gastrointestinal condition with an increasing worldwide prevalence. This research was a systematic review and meta-analysis evaluating the efficacy, safety, and long-term outcomes of endoscopic full-thickness plication (EFTP) for the treatment of GERD.
Methods A comprehensive search of databases was conducted for studies published up to April 2023. We included randomized controlled trials (RCTs) and prospective observational studies that examined the use of EFTP in treating GERD among adult patients. We calculated pooled effect estimates using a random-effects model.
Results EFTP significantly improved GERD Health-Related Quality of Life (GERD-HRQL) scores at 3-, 6-, and 12-month follow-up intervals. A considerable proportion of patients discontinued proton pump inhibitors, with cessation rates of 59% (95% confidence interval [CI]: 0.47–0.71), 68% (95% CI: 0.58–0.78), and 67% (95% CI: 0.46–0.89,) at 3, 6, and 12 months, respectively. At 3 and 6 months, 61% (95% CI: 0.54–0.68) and 66% (95% CI: 0.56–0.76) of patients experienced ≥50% improvement in GERD-HRQL scores. EFTP demonstrated a favorable safety profile, with a low rate of severe adverse events. We observed a 6.76% reduction (95% CI: –14.53–1.02) in the percentage of time with esophageal pH <4, a decrease in DeMeester scores, and fewer total reflux episodes. The average procedure time was 22.75 minutes (95% CI: 22.03–23.48). Subgroup analyses suggest that both the GERDx system and the NDO Plicator are effective and safe in treating GERD.
Conclusions The findings from our study reveal that EFTP is a safe and effective treatment for GERD patients who have not responded adequately to conventional therapies. Given its minimally invasive nature, effectiveness, and limited adverse effects, EFTP emerges as a compelling alternative to conventional surgical procedures.
Thrombosis and Bleeding in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia: A Systematic Review of Published Cases
Authors: Clerici Bianca , Pontisso Eleonora , Aloise Chiara , Peroni Benedetta , Perricone Rosaria , Pisetta Chiara , Scavone Mariangela , Birocchi Simone , Podda Gian Marco 
Published: December 2023

Introduction Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a highly prothrombotic reaction to COVID-19 (coronavirus disease 2019) adenoviral vector vaccines. Its distinct bleeding and thrombotic patterns compared with other platelet consumptive disorders remain unclear.
Methods We performed a systematic review of the literature (PubMed and Embase) up to July 31, 2022, including case reports and case series providing nonaggregate data of VITT patients. Accurate VITT diagnosis required fulfillment of the following criteria: (1) endorsement by the authors, (2) consistent vaccine type and timing, (3) presence of thrombocytopenia and thrombosis, (4) detection of anti-platelet factor 4 antibodies. Data are presented as frequencies with 95% confidence intervals (CIs) calculated with the exact binomial method.
Results We retrieved 143 eligible studies, describing 366 patients. Of 647 thrombotic events, 53% (95% CI: 49–56) were venous thromboses at unusual sites and 30% (95% CI: 27–34) were cerebral venous sinus thromboses (CVSTs). The ratio of venous-to-arterial events was 4.1. Thromboses in most sites were associated with at least another thrombotic event, with the exception of CVST and CNS arterial thrombosis (isolated in 49 and 39% of cases, respectively). Bleeding occurred in 36% (95% CI: 31–41) of patients; 68% (95% CI: 59–75) of bleeding events were intracranial hemorrhages (ICHs). Overall mortality was 24% (95% CI: 19–29), and 77% (95% CI: 58–90) in patients with isolated CVST complicated by ICH.
Conclusion VITT displays a venous-to-arterial thrombosis ratio comparable to heparin-induced thrombocytopenia. However, VITT is characterized by a higher prevalence of CVST and ICH, which contribute to the increased bleeding frequency and mortality.
A Literature Review of Infracolic Gastrostomy Techniques and Outcomes
Authors: Rashid Sana , Jalil Harun , Ginawi Alaaeldin , Mironov Oleg , Mahmood Syed Umair 
Published: December 2023

AbstractPercutaneous radiologic gastrostomies are traditionally done using a supracolic approach due to the perceived increased risk of postprocedural hemorrhage associated with an infracolic approach. Many interventional radiologists will decline attempts at placing a gastrostomy tube in situations of colonic interposition, requiring patients to undergo surgery. The goal of this review was to understand the safety and technique of infracolic gastrostomies to assess the validity of these concerns. There were 12 cases of infracolic gastrostomies identified across two retrospective studies and one case report. All gastrostomy tubes were inserted successfully with no abandoned procedures with the only minor variation in technique being that the colon was displaced superiorly as opposed to inferiorly like in the traditional supracolic approach. Across the two retrospective studies, the percentage of infracolic gastrostomies done during the study period was 1.18% (6 out of 508) and 0.43% (5 out of 1,156). There were no immediate postprocedural complications reported in the study done with six patients who underwent infracolic gastrostomies, but there were two deaths during the follow-up period, both of which were attributed to disease progression. In the study with five patients who had undergone infracolic gastrostomies, there was one minor complication of site soreness along with one case of death due to sepsis secondary to aspiration of the barium contrast used to delineate the colon prior to the procedure. This is a rare complication that can occur when a barium swallow is done, especially in this case where the patient was older and had comorbidities that increased the aspiration risk. Evidently, infracolic gastrostomies have been inserted in the past with minimal complications. However, due to the limited sample size, the safety of this technique cannot be established without future prospective studies.
Succinate dehydrogenase participation in porcine gamete function
Authors: Breininger E. , Rodriguez P. , Gutnisky C. , Alvarez G. , Satorre M. , Martinez S. , Pereyra V. , Vecchi Galenda B. , Cetica P. 
Published: December 2023

Context Porcine gametes require energy for the physiological processes that allow fertilisation. Succinate dehydrogenase (SDH) plays a pivotal role in both, the tricarboxylic acid (TCA) cycle and the respiratory chain. Aims The aim of this work was to study the participation of SDH in the in vitro oocyte maturation, sperm capacitation and acrosome reaction in porcine species. Methods Cumulus–oocyte complexes (COCs) from abattoir-derived porcine ovaries were collected by aspiration and were incubated in maturation media, with the addition of increasing concentrations (0, 1, 5 and 10 mM) of malonate (a specific inhibitor of SDH). Nuclear maturation and cytoplasmatic maturation were analysed. Semen samples were incubated for 2 h in capacitating medium with 40 mM sodium bicarbonate, as sperm capacitation inducer, and the addition of increasing concentrations of malonate (0, 1, 5 and 10 mM). Sperm capacitation state and true acrosomal reaction were evaluated. SDH activity was determined in sperm and oocyte extracts by the spectrophotometric method. Key results The addition of 10 mM of malonate decreased both nuclear and cytoplasmic maturation rates (P < 0.05) without affecting COC viability (assessed using fluorescein diacetate). A lower level of capacitation (induced by bicarbonate) and acrosome reaction (induced by follicular fluid) was observed with the addition of 5 mM of malonate (P < 0.05) without affecting motility and viability of sperm at this concentration. The activity of SDH was 0.35 ± 0.1 × 10−5 and 2.37 ± 0.9 × 10−5 U/COC for immature and in vitro matured COC extracts (P < 0.05) respectively, and 0.44 ± 0.16 U/1010 sperm for boar sperm extracts. Conclusions In conclusion, because it has been proposed that aerobic and anaerobic metabolic pathways of cells are changed depending on the oxygen availability and the composition of metabolic substrates in their environment, our results suggest that energy obtained through the mitochondrial respiration (TCA cycle and oxidative phosphorylation) is necessary to support oocyte maturation, sperm capacitation and acrosome reaction in the porcine species. Implications The study of enzymatic activity in gametes is essential for understanding the mechanisms that control the energy production required to achieve successful fertilisation. This knowledge has significant implications for the development of assisted reproductive technologies.
Rates of sexual partner acquisition from nationally representative surveys: variation between countries and by age, sex, wealth, partner and HIV status
Authors: Calvert Clara , Scott Rachel , Palmer Melissa , Dube Albert , Marston Milly , Wellings Kaye , Slaymaker Emma 
Published: December 2023

Background Knowing levels and determinants of partnership acquisition will help inform interventions that try to reduce transmission of sexually transmitted infections (STIs) including HIV. Methods We used population-based, cross-sectional data from 47 Demographic and Health Surveys to calculate rates of partner acquisition among men and women (15–49 years), and identified socio-demographic correlates for partner acquisition. Partner acquisition rates were estimated as the total number of acquisitions divided by the person-time in the period covered by the survey. For each survey and by sex, we estimated age-specific partner acquisition rates and used age-adjusted piecewise exponential survival models to explore whether there was any association between wealth, HIV status and partner status with partner acquisition rates. Results Across countries, the median partner acquisition rates were 30/100 person-years for men (interquartile range 21–45) and 13/100 person-years for women (interquartile range 6–18). There were substantial variations in partner acquisition rates by age. Associations between wealth and partner acquisition rates varied across countries. People with a cohabiting partner were less likely to acquire a new one, and this effect was stronger for women than men and varied substantially between countries. Women living with HIV had higher partner acquisition rates than HIV-negative women but this association was less apparent for men. At a population level, partner acquisition rates were correlated with HIV incidence. Conclusions Partner acquisition rates are variable and are associated with important correlates of STIs and thus could be used to identify groups at high risk of STIs.