bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological and whole‐genome sequencing analysis of coronally advanced flap with connective tissue graft for the treatment of gingival recession—A case study
Authors: Reddy Saravanan Sampoornam Pape , Manohar Balaji 
Published: November 2023

AbstractBackgroundOral tissue morphogenesis is innately determined and genetically controlled by underlying connective tissue. The connective tissue graft (CTG) harvested from palatal donor sites originally retains “regional specificity” and is considered to be responsible for epithelial keratinization.MethodsThis case study presents histological and genomic outcomes of coronally advanced flap (CAF) with CTG for the management of marginal tissue recession (MTR). The tissue samples harvested at 12‐month postoperative period, during the debulking procedure of the treated site were subjected to Masson's trichrome staining (MTS) and whole‐genome sequencing (WGS).ResultsClinically, the mean root coverage as compared to baseline at 6 months (90%), 12 months (95%), and 24 months (95%) postoperatively was achieved. Overbulking of treated site was evident even after 12 months. Nevertheless, clinically discernible alterations in epithelial keratinization were not present. Although MTS revealed areas of non‐keratinization and para‐keratinization, WGS revealed a significant expression of keratinization genes, neural crest, and positional marker genes.ConclusionsCAF with CTG is still considered the “gold standard” in treatment of MTR. The keratinization of overlying epithelium at sites hitherto where non‐keratinized mucosa is advanced over CTG may not be complete even after 12 months. It is evident from the analysis of the reported case that clinically such sites may appear non‐keratinized despite the expression of genes for keratinization. The complex interplay between genomic and phenotypic expressions serves as a foundation of biological concepts. Nevertheless, it is imperative to acknowledge that the phenotype of an organism is not solely determined by genetic expression and is often influenced by a complex interaction between genetic background and environmental factors.Key SummaryThe connective tissue serves as a medium for transmitting the genetic code and exerting an influence on the properties of the overlying epithelial tissue.

Concrete evidence implies connective tissue plays a significant role in influencing the keratinization process of the overlying epithelium.
Epithelial keratinization following a coronally advanced flap with connective tissue graft is also governed by environmental factors in addition to inherent potential within the graft.
Differences in gene expression profiles may vary from individuals, teeth and among sites.
Congenital solitary kidney in autosomal dominant polycystic kidney disease: Where do known genes end and the unknown begin?
Authors: Bucci Romina , Tunesi Francesca , De Rosa Liliana Italia , Carrera Paola , Mancassola Giulia , Catania Martina , Vezzoli Giuseppe , Sciarrone Alibrandi Maria Teresa 
Published: November 2023

Key Clinical MessageWe present the case of a 41‐year‐old man patient diagnosed with solitary left kidney with few cysts. He has a family history of unilateral renal agenesis (URA) but no for autosomal dominant polycystic kidney disease (ADPKD). Genetic testing revealed PKD1 gene intron 11 heterozygous nucleotide variant c.2854‐23G>T, but no gene mutation implicated in URA. Just eight cases of ADPKD with one kidney have been recorded globally. PC1 and PC2 disruption, causing primary cilia malformation or absence resulting in relevant in the first embryonic development alteration. Cillia's crucial significance in many diseases will require more research.
Proton Conduction over the Zeolite with Surface Water Cluster for the Water Electrolysis at Neutral Condition
Authors: Tashiro Keigo , Saito Taisei , Goto Kojiro , Masuda Junki , Miyakage Takumi , Shimoda Shuhei , Toyao Takashi , Tsunoji Nao , Shimizu Ken‐ichi , Matsumoto Hiroshige , Satokawa Shigeo 
Published: November 2023

AbstractElectrolytic hydrogen production from water at neutral pH was achieved by using novel proton (H+) conduction system assisted by zeolite. Experimental and computational insights demonstrated that defective silanol nest generated by dealumination played an important role in the formation of water clusters and the H+ conduction over the zeolites proceeded via exchange of H‐bonding between water molecules in the cluster. In addition, a proper balance between hydrophilicity and hydrophobicity is required for effective H+ conduction and silanol nest afford the balance. Furthermore, the contribution of hydrophilicity of the zeolite for the adsorption of water molecules became more drastic at high temperatures. Water electrolysis efficiency was strongly dependent on the H+ conductivity over the beta‐type zeolite. The electrolytic cell containing the zeolite has the potential to be applied to the new hydrogen production system.
On Demand Synthesis of C3−N1’ Bisindoles by a Formal Umpolung Strategy: First Total Synthesis of (±)‐Rivularin A
Authors: Tokushige Keisuke , Abe Takumi 
Published: November 2023

AbstractIn this work, a straightforward synthesis of C3−N1’ bisindolines is achieved by a formal umpolung strategy. The protocols were tolerant of a wide variety of substituents on the indole and indoline ring. In addition, the C3−N1’ bisindolines could be converted to C3−N1’ indole‐indolines and C3−N1’‐bisindoles. Also, we have successfully synthesized (±)‐rivularin A through a biomimetic late‐stage tribromination as a key step.
A Nitronyl Nitroxide‐Substituted Benzotriazinyl Tetraradical**
Authors: Tretyakov Evgeny V. , Zayakin Igor A. , Dmitriev Alexey A. , Fedin Matvey V. , Romanenko Galina V. , Bogomyakov Artem S. , Akyeva Anna Ya. , Syroeshkin Mikhail A. , Yoshioka Naoki , Gritsan Nina P. 
Published: November 2023

AbstractHigh‐spin organic tetraradicals with significant intramolecular exchange interactions have high potential for advanced technological applications and fundamental research, but those synthesized to date possess limited stability and processability. In this work, we have designed a tetraradical based on the Blatter's radical and nitronyl nitroxide radical moieties and successfully synthesized it by using the palladium‐catalyzed cross‐coupling reaction of a triiodo‐derivative of the 1,2,4‐benzotriazinyl radical with gold(I) nitronyl nitroxide‐2‐ide complex in the presence of a newly developed efficient catalytic system. The molecular and crystal structure of the tetraradical was confirmed by X‐ray diffraction analysis. The tetraradical possesses good thermal stability with decomposition onset at ∼150 °C under an inert atmosphere and exhibits reversible redox waves at −0.54 and 0.45 V versus Ag/AgCl. The magnetic properties of the tetraradical were characterized by SQUID magnetometry of polycrystalline powders and EPR spectroscopy in various matrices. The collected data, analyzed by using high‐level quantum chemical calculations, confirmed that the tetraradical has a triplet ground state and a nearby excited quintet state. The unique high stability of the prepared triazinyl‐nitronylnitroxide tetraradical is a new milestone in the field of creating high‐spin systems.
Efficient multiply robust imputation in the presence of influential units in surveys
Authors: Chen Sixia , Haziza David , Michal Victoire 
Published: November 2023

AbstractItem nonresponse is a common issue in surveys. Because unadjusted estimators may be biased in the presence of nonresponse, it is common practice to impute the missing values with the objective of reducing the nonresponse bias as much as possible. However, commonly used imputation procedures may lead to unstable estimators of population totals/means when influential units are present in the set of respondents. In this article, we consider the class of multiply robust imputation procedures that provide some protection against the failure of underlying model assumptions. We develop an efficient version of multiply robust estimators based on the concept of conditional bias, a measure of influence. We present the results of a simulation study to show the benefits of our proposed method in terms of bias and efficiency.
Bending Relaxation of H2O by Collision with Para‐ and Ortho‐H2
Authors: García‐Vázquez Ricardo Manuel , Faure Alexandre , Stoecklin Thierry 
Published: November 2023

AbstractWe extend our recent theoretical work on the bending relaxation of H2O in collisions with H2 by including the three water modes of vibration coupled with rotation, as well as the rotation of H2. Our full quantum close‐coupling method (excluding the H2 vibration) is combined with a high‐accuracy nine‐dimensional potential energy surface. The collisions of para‐H2O and ortho‐H2O with the two spin modifications of H2 are considered and compared for several initial states of H2O. The convergence of the results as a function of the size of the rotational basis set of the two colliders is discussed. In particular, near‐resonant energy transfer between H2O and H2 is found to control the vibrational relaxation process, with a dominant contribution of transitions with
=
,
and
being respectively the H2 initial and final rotational quantum numbers. Finally, the calculated value of the H2O bending relaxation rate coefficient at 295 K is found to be in excellent agreement with its experimental estimate.
High voltage gain quasi Z‐source inverter unified with switched three‐winding coupled inductor
Authors: Yousefi Moghadam Farshid , Abbasi Vahid , Hemmati Siroos 
Published: November 2023

SummaryThis paper presents a new high voltage gain quasi Z‐source inverter consisting of a switched‐inductor unit. A coupled inductor including three windings is utilized in structure of the switched inductor in a way to increase voltage gain effectively. In addition, the configuration includes an active switch with low number of components that has positive effects on voltage gain and two of its components recycles stored energy of the coupled inductor similar to a clamp circuit. The converter boosts voltage appropriately in low shoot‐through duty cycles and transfers power with a continuous input current, leading to a reduction in losses, requiring smaller output filter and improving the efficiency. Also, the converter can operate in high modulation index for similar voltage gains compared to the other works which improves quality of outputs. Low number of components and fewer cores for inductors are considered during the design of the converter, causing some superiorities for it in comparisons. In addition, the presented converter has appropriate condition from the viewpoint of voltage stress on its diodes. To validate quality of the converter performance, a 240‐W prototype is prepared that converts 35‐ to 60‐V DC to three‐phase sinusoidal voltages where effective voltage of each phase is equal to 110 V.
Benchtop fine needle aspirations: An untapped source of cytologic educational material
Authors: Wu Yubo , Lepe Marcos 
Published: November 2023

AbstractFine needle aspirations (FNAs) are a valuable tool for the diagnosis of a wide variety of lesions. However, obtaining proficiency in performing FNAs and finding simulated scenarios where one can practice specimen adequacy and slide smearing can all be challenging. Benchtop FNAs of fresh surgical specimens offer a novel training opportunity that addresses these needs. In this study, we describe the feasibility and practicality of benchtop FNAs of fresh surgical specimens as a training tool. We performed benchtop FNAs on multiple specimen types, although most were partial and radical nephrectomies. We documented this approach to cytology training and have provided examples of slides that were generated, along with the surgical pathology correlate. Our results suggest that benchtop FNAs of fresh surgical specimens can be a valuable training tool in the arsenal of today's cytopathologist. This technique offers several advantages over traditional training methods, including the ability to generate high‐quality cytology slides, provide cyto‐histo correlation, and practice almost immediate gross‐microscopic correlation. However, there are also some disadvantages to this approach, including the need for immediate access to fresh surgical specimens and the potential for artifacts to be introduced. Overall, we believe that benchtop FNAs of fresh surgical specimens offer a promising new training tool that can maximize training opportunities, especially in institutions where the FNA volume is low.
A Passing Problem: Evaluating Harm and Benefit in Autism Research
Authors: Ne'eman Ari , Richman Kenneth A. , McCarthy Allison M. , Wilkenfeld Daniel 
Published: November 2023

ABSTRACTAutism research frequently seeks to evaluate interventions or inform their development. Unfortunately, researchers often assume that autism intervention should reduce autistic traits, effectively setting as a goal of treatment that autistic people attempt to “pass” as nonautistic. A growing body of evidence highlights serious potential harms from passing demands. We discuss why it is important for institutional review boards (IRBs) to scrutinize autism research for clinical passing demands, and we document the existence of such demands in outcome measures commonly employed in autism research. We propose an ethical framework for IRBs and others to make use of in evaluating the ethical appropriateness of particular treatment goals in autism intervention or intervention‐adjacent research, emphasizing that treatment goals should be in pursuit of a beneficial nonpassing purpose and be the least burdensome means of accomplishing such a purpose. We also highlight potential promising practices for IRBs, investigators, and other stakeholders seeking to address these issues in autism research.
Circulating CD8 lymphocytes predict response to atezolizumab–bevacizumab in hepatocellular carcinoma
Authors: Gramantieri Laura , Suzzi Fabrizia , Bassi Cristian , D'Abundo Lucilla , Tovoli Francesco , Bruccoleri Mariangela , Marseglia Mariarosaria , Alimenti Eleonora , Fornari Francesca , Negrini Massimo , Iavarone Massimo , Piscaglia Fabio , Giovannini Catia 
Published: November 2023

AbstractDue to the lack of biomarkers predictive of response to atezolizumab–bevacizumab, the standard of care for advanced HCC, we analyzed baseline and early on‐treatment variation of peripheral lymphocyte populations of 37 prospective patients treated by atezolizumab–bevacizumab and in 15 prospective patients treated by sorafenib or lenvatinib (TKIs). RNAseq analysis followed by RT‐PCR validation on patients‐derived PBMC was also performed. At first imaging, re‐evaluation 13 patients receiving atezolizumab–bevacizumab, showed an objective response, 17 stable disease, while 7 were nonresponders. Baseline CD8+ and CD8+PD‐L1+ peripheral lymphocytes were lower in responders versus nonresponders (T‐test, p = 0.012 and 0.004, respectively). At 3 weeks, 28 of 30 responders displayed a rise of CD8+PD1+ lymphocytes with a positive mean fold change of 4.35 (±5.6 SD), whereas 6 of 7 nonresponders displayed a negative fold change of 0.89 (±0.84 SD). These changes were not observed in patients treated by TKIs. TRIM56, TRIM16, TRIM64, and Ki67 mRNAs were validated as upregulated in responders versus nonresponders after 3 weeks after treatment start, providing possible evidence of immune activation. Baseline CD8+ and CD8+PD‐L1+ peripheral lymphocytes and early changes in CD8+PD1+ lymphocytes predict response to atezolizumab–bevacizumab providing noninvasive markers to complement clinical practice in the very early phases of treatment of HCC patients.
Room‐Temperature Synthesis of a Compositionally Complex Rare‐Earth Carbonate Hydroxide and its Conversion into a Bixbyite‐Type High‐Entropy Sesquioxide
Authors: Bernauer Jan , Trapp Maximillian , Wiehl Leonore , Kleebe Hans‐Joachim , Ionescu Emanuel 
Published: November 2023

AbstractIn the present work, the solvent‐deficient synthesis of the high‐entropy rare‐earth carbonate hydroxide RE(CO3)(OH) (RE=La, Ce, Pr, Nd, Sm, and Gd) and its thermal conversion into bixbyite‐type sesquioxide RE2O3 are reported for the first time. The high‐entropy rare earth carbonate hydroxide was prepared via mechanochemical reaction of the corresponding metal nitrate hydrates with ammonium hydrogen carbonate followed by the removal of the NH4NO3 by‐product. Calcination of the carbonate hydroxide precursor in ambient atmosphere at temperatures in the range from 500 to 1000 °C led to the high‐entropy rare earth sesquioxide which exhibited a bixbyite‐type structure (
) independent of the calcination temperature. Transmission electron microscopy (TEM) investigation revealed the homogeneous distribution of all six rare earth cations in the high‐entropy sesquioxide lattice, however, with some compositional variation between individual grains. The bixbyite‐type structure may be considered as the result of heavy doping of the fluorite‐type CeO2 lattice with the other rare earth cations, which leads to a high concentration of oxygen vacancies, as revealed by electron diffraction and Raman spectroscopy data. The solvent‐deficient synthesis method used in the present study is considered as a valuable, straightforward and easily up‐scalable method to synthesize compositionally complex oxide ceramics.
Photocatalytic Oxidation of Benzylamine by Cadmium‐Based MOF Constructed with Flexible Carboxylic Acid
Authors: Wang Danxiao , Sun Chunfeng , Wang Yanxia 
Published: November 2023

AbstractMOFs (Metal organic frameworks) have diverse structures that present great potential for light capture and light conversion. Therefore, MOFs are widely used in the study of photocatalysis. However, there still are some challenges in photocatalytic organic conversion upon MOFs under mild conditions, such as poor light absorption performance. Here, we successfully synthesized a new Cd‐connected two‐dimensional MOF by a simple hydrothermal method, termed [Cd(PLA)(4,4’‐bipy)0.5 ]⋅(DMF) (Cd‐PLA) (PLA= phenylene‐diacetic acid, 4,4’‐bipy= 4,4’‐bipyridine and DMF= N,N’‐dimethyl formamide). The bpy‐containing Cd‐PLA possesses excellent light harvest ability and suitable photocatalysis energy potential, allowing it to be a remarkable photocatalyst with highly efficiency and selectivity for the photo‐oxidation of benzylamine. This work provides an efficient, economical, and green way for oxidation of amines to produce imines under ultraviolet light irradiation.
In vitro gastrointestinal digestion methods of carbohydrate‐rich foods
Authors: Dávila León Rebeca , González‐Vázquez Marcela , Lima‐Villegas Karen Estefania , Mora‐Escobedo Rosalva , Calderón‐Domínguez Georgina 
Published: November 2023

AbstractThe trend toward healthier food products has led to an increase in the research of in vitro gastrointestinal digestion methods. Among the most used models, static models are the simplest. Most static models have three stages: oral, gastric, and intestinal, simulating the enzymatic, electrolyte, pH, temperature, and bile salt conditions. The studies that have taken the most notice are those related to antioxidant activity, followed by those dealing with proteins and carbohydrates using most of them static in vitro digestion models. The number of these studies has increased over the years, passing from 45 to 415 in a 10‐year period (2012–2023) and showing an interest in knowing the impact of food on human health. Nevertheless, published papers report different methodologies and analytical approaches. This review discusses the similarities and differences between the published static in vitro gastrointestinal digestion methods, with a focus on carbohydrates, finding that the most used protocol is Infogest, but with differences, mainly in the type of enzymes and their activity. Regarding in vitro gastrointestinal digestion of carbohydrates, many of the published studies are related to food and biomacromolecules, being the oral phase the most omitted, while the intestinal phase in the most diverse. Other methodologies to study the intestinal phase have been recommended, but the number of in vitro digestion studies using these methodologies (RSIE and BBMV) is still scarce but could represent a good alternative to analyze carbohydrates foods when combining with Infogest. More studies are required in this area.
Reconsidering the path for neural and physiological methods in consumer psychology
Authors: Clithero John A. , Karmarkar Uma R. , Nave Gideon , Plassmann Hilke 
Published: November 2023

AbstractRecent decades have witnessed a burst of neuroscience research investigating mental and physiological processes central to consumer behavior, including sensory perception, memory, and decision making. Nonetheless, few publications that include neural and physiological measures, or develop conceptual frameworks around neuroscience principles, have been published in consumer psychology. It is clear that “consumer neuroscience” has thus far not lived up to its promises in the marketing literature. We suggest three main reasons for this. First, neural and other biological markers are often mistaken to be identical to the overlaying psychological constructs in traditional consumer psychology work. Second, somewhat surprisingly, there has been an overly narrow utilization of neural data. Most previous work focused on linking existing behavioral phenomena or psychological constructs central to consumer research to neural correlates using brain imaging techniques while ignoring other methods. We argue that much can be gained from improved integration of physiological measures and through them, different levels of analysis. Third, there remain significant structural hurdles to the broad adoption of neural and physiological measures for consumer researchers. We outline how addressing these three components can translate to a more holistic understanding of the consumer via both broader and deeper consumer insights.
Prognostic significance of body mass index in small‐cell lung cancer: Exploring the relationship with skeletal muscle status
Authors: Kwon Yong Jae , Yoon Young Cheol , Kim Hyun Su , Cha Min Jae , Park Sehhoon , Lee Ji Hyun 
Published: November 2023

AbstractBackgroundWe investigated the prognostic significance of body mass index in small‐cell lung cancer and explored whether skeletal muscle status affects the body mass index–survival relationship.MethodsThis retrospective study evaluated data from patients who underwent platinum‐etoposide chemotherapy for small‐cell lung cancer between March 2010 and December 2021. Skeletal muscle status was assessed using non‐contrast computed tomography images of baseline positron‐emission tomography‐computed tomography, with the skeletal muscle index defined as the cross‐sectional area of skeletal muscle divided by height squared, and the average attenuation values of skeletal muscle. Cox proportional hazards regression analysis was used to determine the correlations of body mass index, skeletal muscle metrics, and overall survival.ResultsWe analysed the data of 1146 Asian patients (1006 men and 140 women, with a median age of 67 years [interquartile range: 61–72 years]), including 507 and 639 patients with limited and extensive disease, respectively. Being underweight, defined as a body mass index <18.5 kg/m2, was associated with shorter overall survival, independent of clinical covariates in both the limited‐disease (hazard ratio, 1.77; 95% confidence interval, 1.01–3.09) and extensive‐disease (hazard ratio, 1.71; 95% confidence interval, 1.18–2.48) groups. The prognostic value of being underweight remained significant after additional adjustment for skeletal muscle index and attenuation in both limited‐disease (hazard ratio, 1.96; 95% confidence interval, 1.09–3.51) and extensive‐disease (hazard ratio, 1.75; 95% confidence interval, 1.17–2.61) groups.ConclusionsBeing underweight is an independent poor prognostic factor for shorter overall survival in Asian patients with small‐cell lung cancer, regardless of skeletal muscle status.