bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanotechnology-based Assays for the Detection of Cancer through Sputum
Authors: Singh Dilpreet 
Published: November 2023

Abstract:
Cancer remains a formidable global health challenge, underscoring the critical need for
early and accurate diagnostic tools. In recent years, nanotechnology has emerged as a promising
frontier in cancer detection, offering innovative approaches to enhance sensitivity, specificity, and
convenience in diagnostics. This comprehensive review delves into the intersection of nanotechnology
and sputum-based assays for cancer detection. Sputum, a readily accessible biomarker source, has
gained increasing attention due to its potential to house early cancer biomarkers. By harnessing the
unique properties of nanoparticles, this review explores how nanotechnology is revolutionizing sputum-
based cancer detection. We examine the intrinsic attributes of sputum as a diagnostic fluid, the
diverse applications of nanoparticles, and the evolving landscape of cancer-specific biomarkers.
Moreover, we provide insights into various nanotechnology assay techniques and their clinical implications
while highlighting the challenges and future prospects in this dynamic field. This review
aims to elucidate the transformative impact of nanotechnology on cancer diagnostics through sputum,
offering a roadmap towards earlier and more accurate cancer detection.
Preparation of Lycium barbarum Active Glycopeptide and Investigation of Its
Apoptotic Effects on Melanoma
Authors: Qi Jinghua , Qi Xingli , Chen Hongyuan , Rui Wen 
Published: November 2023

Introduction:
The increasing number of studies have shown that Lycium barbarum polysaccharides
possess anti-tumor effects. However, the determination of the active ingredients and their mechanism against
melanoma inhibition are still unknown.

Methods:
In this study, we aimed to investigate the mechanisms of action of Lycium barbarum active glycopeptide
(LBAG) on melanoma. LBAG was extracted and isolated from the fruit of Lycium barbarum using aqueous
alcoholic precipitation and identified using ultra-performance liquid chromatography-quadrupole-time of flightmass
spectrometry. Various assays including cell apoptosis, cell cycle analysis, colony formation assay, cell
scratch test, flow cytometry, and Western blot were performed to evaluate the effects of LBAG on melanoma.

Results:
The results showed that LBAG has a molecular weight of 10-15 kDa and contains Man, Rha, GlcA, Glc,
Gal, and Ara18 amino acids. Treatment with LBAG significantly decreased B16 cell proliferation and induced
cell cycle arrest at the G0/G phase, accompanied by the accumulation of reactive oxygen species. Western blot
analysis revealed that the phosphorylation of P38-MAPK and AKT, as well as the expression of N-acetyl-Lcysteine,
were related to cell apoptosis and cell cycle regulation. In mouse xenografts, LBAG inhibited tumor
growth through the P38-MAPK and AKT signaling pathways.

Conclusion:
In conclusion, the anti-melanoma activity of LBAG may induce apoptosis in cancer cells through
ROSmediated activation of the P38-MAPK and AKT signaling pathways. These findings provide a foundation
for further research on the anti-melanoma potential of LBAG.
Spontaneous Intracranial Hemorrhage and Acute Respiratory Distress
Syndrome Associated with Dengue: A Case Report
Authors: Singh Jitendra , J. Bhavya , Dinkar Anju , Kumar Nilesh , Kumar Kailash , Singh Santosh Kumar 
Published: November 2023

Background::
Dengue is a major health burden worldwide, notably in tropical and subtropical
countries, with symptoms ranging from asymptomatic infection to severe hemorrhagic or shock
syndrome. The clinical and biochemical profile of dengue has been shown in the literature to be
expanding as more atypical signs have been added over the past few decades. Most dengue-related
symptoms are typically mild to moderate and self-limited. However, intracranial hemorrhage and
acute respiratory distress syndrome in severe dengue is an event that has been encountered uncommonly.

Case presentation::
A 30-year-old female presented with complaints of fever, headache, cough, and
altered sensorium. Later, she was diagnosed with severe dengue fever complicated by dengue hemorrhagic
fever, which manifested as subarachnoid and subdural bleeding and acute respiratory distress
syndrome. She was managed conservatively with a positive outcome.

Conclusion::
Atypical manifestation, though rare, should be kept in mind while dealing with severe
dengue patients, as early detection based on anticipated risk factors and timely treatment have the
potential to save lives.
An Overview of Biosynthetic Pathway and Therapeutic Potential of Naringin
Authors: Goyal Jugnu , Goyal Rishab , Kumar Verma Prabhakar 
Published: November 2023

Abstract:
Naringin is a naturally obtained chemical from plants that is formed as a secondary metabolite in them. It possesses significant properties that are
useful to humans. The primary sources of naringin extract include fruits of the citrus family which are Citrus reticulata, Citrus bergamia, Citrus
aurantium, and Citrus paradisi. It belongs to a class of alcohols primarily consisting of a fused ring system which is responsible for its different
medicinal properties, as a consequence, it is widely used in the nutraceutical market nowadays. Nutraceuticals are a part of food that provides
health benefits by giving supplements to the body; their final extract form is white in color having crystalline properties with a melting point of
83oC and solubility of 1 mg/ml at 40oC. The absorption of nutraceuticals occurs inside the stomach as it requires a specific pH range between
3.5-4.2. After absorption, it gets converted into naringenin in the liver via a cascade of reactions like dehydrogenation, acetylation, and hydrolysis.
Several enzymes are responsible for its conversion into an active form which includes cytochrome P-450, and chalcone isomerase. Its
bioavailability depends on a variety of factors including disease condition, gastric moiety, pH of absorption site, the presence of other drugs, and
many more. It gets metabolized in the liver itself and finally excreted in the urine. It can be tolerated by the body at high doses, but other conditions
can cause its toxicity inside the human body. Its primary properties include anti-inflammatory actions, anti-aging properties, antibacterial
properties, anti-cancer properties, and obesity issues.
The Pharmacological Significance of Convolvulus Prostratus: Modern
Perspectives of An Ancient Herb
Authors: Gupta Jeetendra Kumar , Verma Jyoti , Khandelwal Girdhar , Singh Krishanveer , Singh Kuldeep 
Published: November 2023

Abstract:
Convolvulus prostratus, also known as sankhapushpi, is a very adaptable plant frequently used as a nervine tonic, nootropic, and rejuvenator in
cases of insanity and epilepsy and has a broad spectrum of beneficial properties. Several medicinal qualities, including anxiety, neuroprotective,
antioxidant, analgesic, immunomodulatory, antibacterial, antidiabetic, and cardioprotective effects, have been related to this herb in ancient
literature. Numerous bioactive phytoconstituents, including kaempferol(flavonoid), ceryl alcohol, scopolamine(phenolics), and convolamine
(alkaloid), are associated with the therapeutic capabilities of this herb. The Whole herb or its juice is credited with alterative, antiphlogistic, and
nervine tonic action. Additionally, the involvement of C. prostratus extracts in neurodegenerative was thoroughly established. Although this
significant herb has comprehensive preclinical studies, thorough clinical research and mechanistic mode-of-action studies still need to be
conducted. With a detailed analysis of the research gaps, the current review aims to highlight the phytonutrient constituents, beneficial
characteristics, and therapeutic properties of C. prostratus. The creation of CNS phytopharmaceuticals, derived from C. prostratus, is hoped to
flourish due to the scientific upgrade on the ethnomedicinal characteristics of this herb.
Soft Switching Technique in a Modified SEPIC Converter with MPPT using Cuckoo Search Algorithm
Authors: Purushothaman Srinivasan , Senthamarai Heeravathi , Prasanna M. Jay , Pillai Sreedharsh R. , Dhanush M. 
Published: November 2023

:
MPPT refers to the process of continuously tracking and adjusting the operating point
of a photovoltaic (PV) system to maximize the power output from the solar panels. The operating
point at which a PV system produces the most power under a specific set of environmental circumstances
is known as the maximum power point (MPP). The Maximum power point tracking
(MPPT) technique is used to overcome the challenges of PV arrays with variable irradiance levels,
which collects the greatest power from the PV array. Standalone PV systems, as well as gridconnected
systems, can benefit from a DC-DC converter with MPPT. This study compares the
standard perturbation and observation (P&O) technique with the soft-switching method used in
the SEPIC converter utilizing the cuckoo search (CS) algorithm using MATLAB/Simulink. Reviewing
the simulation results and assessing the SEPIC converter's performance.

Background:
SEPIC soft-switching converter, the soft-switching technique is applied to the
SEPIC converter topology. It typically uses additional components, such as inductor and capacitors,
to enable soft-switching operation. These additional components help to control the voltage
and current waveforms across the main switching devices, reducing switching losses.

Methods:
The proposed method uses a soft switching technique to reduce switching losses and to
improve efficiency. Soft switching is used in SEPIC (Single Ended Primary Inductor Converter)
converters, a type of DC-DC converter, to enhance their performance. The projected solution further
addresses the maximum power point tracking (MPPT) issue in PV systems using the Cuckoo
Search (CS) method.

Results:
Soft switching technique is implemented in SEPIC converters to reduce these switching
losses. In this system, Zero Voltage Switching (ZVS) involves turning on the switch when the
voltage across it is zero. This allows the current to flow through the switch without creating any
significant switching losses. CS algorithm can track the MPP quickly and accurately, it exhibits
less prone to oscillations, easily monitor the MPP under a variety of weather circumstances. However,
it exhibits negligible oscillation in a steady state, which results in significant power savings.

Conclusion:
The modified SEPIC converter with a soft-switching MPPT cuckoo algorithm is
used with a solar-powered system. A prototype comprising a solar panel, a SEPIC converter, a
driver, and a controller circuit was created. A soft-switching SEPIC converter with an MPPT
cuckoo algorithm for the PV system is implemented, as are the converter operation, converter
analysis, and theoretical analysis, and a controller circuit is analysed. The PV system, MPPT controller
with tracking algorithm, and PMSM load were used in the system simulation. A 60-watt
SEPIC converter prototype is built, and the outcomes are also tested experimentally.
AZOFRA AGUSTÍN, Eduardo; GARCÍA-TALEGÓN, Jacinta y GUTIÉRREZ-HERNÁNDEZ, Alexandra M. (eds.), La piedra en el patrimonio monumental, Salamanca, Ediciones Universidad Salamanca, 2022
Authors: MARTÍNEZ MARÍN Cruz María 
Published: November 2023

Esta novedad editorial forma parte de un proyecto de investigación sobre el uso de la piedra granítica en el Patrimonio Monumental del área sur-occidental de Castilla y León. Se enfoca en la utilización de la piedra granítica en la arquitectura de Salamanca, destacando su resistencia y su combinación con la arenisca de Villamayor en algunos casos.
La primera parte del libro aborda la conservación y restauración de la piedra. Una segunda parte está centrada en investigaciones relacionadas con el uso de materiales pétreos en el patrimonio monumental, como el empleo del granito en Ávila, el simbolismo del pórfido en un proyecto real, y el uso ornamental de la piedra en el hospital de las Cinco Llagas, entre otros temas. La tercera sección se enfoca en el estudio de las canteras históricas y el transporte de la piedra, incluyendo estudios sobre canteras graníticas en el área de Ávila, itinerarios geoturísticos, miliarios en la vía de la Plata, canteras en Bailén, calizas jaspeadas en Espejón, y el uso de bueyes en el transporte de piedra. Se revisan también las rutas y caminos de la Edad Moderna.
Initial management and survival of patients with primary metastatic bladder cancer before the immunotherapy era: a population-based study from Norway
Authors: Møller Christina Tanem , Tafjord Gunnar , Blindheim Augun , Berge Viktor , Fosså Sophie , Andreassen Bettina Kulle 
Published: November 2023

Before immunotherapy became part of the management of metastatic bladder cancer (mBC), systemic anti-cancer treatment comprised primarily of platinum-based chemotherapy. The objective of this study was to describe the characteristics, the initial management, overall survival (OS) and hospitalisations of patients with mBC before 2018 when immunotherapy for mBC was introduced in Norway.
Material and methods: It is a nationwide population-based study of primary mBC patients (diagnosed 2008-16). Descriptive statistics were applied and stratified for four initial management options (≤150 days after BC diagnosis): chemotherapy, major local treatment (cystectomy/pelvic radiotherapy), multimodal treatment (chemotherapy and local) and no anti-cancer treatment beyond transurethral resection of bladder tumour (untreated). Group differences were evaluated by Chi-square and Kruskal–Wallis test; OS was estimated with Kaplan–Meier.
Results: Of the 305 patients included, 76 (25%) patients had chemotherapy, 46 (15%) patients had major local treatment, 21 (7%) patients had multimodal treatment and 162 (53%) patients were untreated. Median OS ranged from 2.3 months (untreated) to 9.8 months (chemotherapy). Patients who received treatment had a higher rate of hospitalisation, with a median stay of three to four times that of untreated patients.
Conclusion: Before immunotherapy, more than 50% of patients with primary mBC did not receive any initial anti-cancer therapy and had a poor survival. Patients treated with chemotherapy had inferior median OS compared to those treated with comparable systemic strategies in contemporary trials. Our results provide a basis for future research on treatment and survival after the introduction of immunotherapy for mBC, aiming to improve the care and outcome of patients with mBC.
Pengaruh Aksesibilitas, Sistem Pengendalian Internal Pemerintah, Transparansi, Pemanfaatan Teknologi Informasi Terhadap Akuntabilitas Pengelolaan Dana Desa
Authors: Doyosi Riri Putri , Abdullah Abdullah , Fadli Fadli 
Published: November 2023

AbstractPurpose – This purpose of this study is to examine the accountability of village fund management in terms of accessibility, government internal control system, transparency and use of information technology.Design/methodology/approach – This study used a survey method through the distribution of questionnaires conducted in 49 villages spread across 6 sub-districts in Lebong regency, with a total of 49 village treasurer respondents. The relationship between variables was analyzed using SPSS.Findings – The results of multiple regression analysis shows that 1) Accessibility has a negative influence on the accountability of des fund management. 2) The government's internal control system has a positive influence on accountability of village fund management. 3) Transparency has a positive influence on the accountability of village fund management. 4) Utilization information technology has a positive influence on the accountability of village fund management.Originality/value – This research is aimed at village governments regarding village financial management. This was done to see more clearly the form of accountability of village governments in managing village funds, where there are still many village governments that cannot be accountable for village funds, especially Lebong district. As well as explaining how the government's internal control system, accessibility, transparency and use of information technology explain the accountability of village fund managementResearch limitations/implications – The limitation of this research is that the statements in the accessibility questionnaire are still inaccurate in explaining the accessibility variables. The implication of this research is to prove that agency theory in line with the variables of accessibility, internal control system, transparency and use of information technology related to accountability village fund management. According to the results of this research, it is hoped that it can provide benefits for the village government as a reference or material for consideration in making decisions regarding the importance of responsible management village funds and as a consideration in making policies for increasing accountability of village funds.Keywords: Accessibility, accountability of village fund management, government internal control system, transparency, utilization of information technology.Article Type: Research Paper
Thermal Performance of Double Pass Solar Air Collector: Numerical and Experimental Investigation
Authors: Belloufi Yousef , Rouag Amar , Aissaoui Faris , Benmachiche Abdelmoumene-Hakim , Brima Abdelhfid 
Published: November 2023

Abstract
In this research study, the development of a theoretical model to estimate the efficiency of a double pass solar air heater (DPSAH) was the main objective. The mathematical model was compared to experimental results and found to be in agreement, both qualitatively and quantitatively. The model used energy balance equations to determine the outlet temperature and could solve the temperature equations of each component of the heater simultaneously. A matrix inversion method was used for this purpose. The study found that increasing the Nusselt number led to an increase in energy efficiency, but also caused a drop in outlet temperature at any solar radiation. The mass flow rate (MFR), with larger flow rates resulting in better efficiencies, had a significant impact on the double pass air heater's efficiency. Thus, increasing of DPSAH’s length increases its thermal performances and reach its maximum values for L=9m. These findings could be beneficial in selecting the most efficient design parameters for DPSAH.
Structural and Thermodynamic Properties oF Cu2ZnSnS4 Material: Theoretical Prediction
Authors: Boutahar L. , Benamrani A. , Rouabah Z. , Daoud S. 
Published: November 2023

Abstract
The present work aims to investigate the structural and thermodynamic properties of homogenous tetragonal Cu2ZnSnS4 (CZTS) absorber material in Kesterite phase using first-principle calculations based on density functional theory (DFT). This approach requires only knowledge of the atomic species and crystal structure to predict several physical properties of materials. The Quantum Espresso code within the Ultra Soft pseudopotentials (USPP) and the local density approximation (LDA) were used in the calculations. Equilibrium unit cell volumes, bulk modulus, as well as the pressure derivative of the bulk modulus are predicted. In addition, several thermodynamic properties, especially: the Debye’s vibrational energy, the vibrational free energy, the vibrational entropy, and the constant volume heat capacity at different temperatures T of Cu2ZnSnS4 material are calculated and discussed. Our study shows that the vibrational energy, the entropy and the constant volume heat capacity increase with increasing temperature, while the vibrational free energy decreases monotonously with the increase of temperature.
Enhancing the Green Energy Revolution: Analyzing the Impact of Financial and Investment Processes on Renewable Energy Projects in Kazakhstan
Authors: Shakeyev Sayan , Baineyeva Parida , Kosherbayeva Aigul , Yessenova Gulmira , Zhanseitov Azamat 
Published: November 2023

Abstract
As a fossil fuel-dependent nation, Kazakhstan is caught between issues and possibilities in its search for a sustainable energy transition. Despite its tremendous resources, Kazakhstan’s renewable energy capacity is 1%, much behind its non-renewable peers. According to this research, green fiscal policies in renewable energy firms are needed to reduce the country’s political and economic dependence on the global oil sector. This report emphasizes regional collaboration and Kazakh-stan’s potential leadership in Central Asian Green Economy projects. Kazakhstan can promote renewable energy adoption and economic sustainability by forming regional alliances.
Challenges lie ahead on the green future path, so this paper addresses legislative, infrastructure, financial, and data barriers to green fiscal initiatives in Kazakhstan. It stresses the significance of holistically tackling these concerns, including banking and stock market reforms and sustainable planning. Policymakers and stakeholders in Kazakh-stan can use the research findings to boost the economy, fight corruption, and increase political engagement. Upskilling the workforce to support green technology and local renewable energy production is recommended. The report recommends proactive global crisis prediction and management to help Kazakhstan handle economic and environmental challenges. Hence, the above actions are crucial to Kazakhstan’s goal of industrialization by 2050. Kazakhstan can lead a world rapidly moving to green energy by committing to green fiscal methods, regional collaboration, and addressing the many obstacles to development. By doing so, it can safeguard its future and advance the global green energy revolution.
Motivations and Expectations of Olympic Volunteers: Building a Legacy of Personal Development as a Key Factor for the Success of Sports Mega-Events
Authors: Teixeira Mário Coelho , Banza Telma Frade , Almeida Nuno Castanheira , Sesinando André Dionísio 
Published: November 2023

Abstract
The scientific breakthrough in understanding the role of sports volunteers, as well as the importance of motivation and expectations management in decision-making, has boosted several studies, helping to reinforce the conceptual idea of a sports legacy, especially in relation to the participation and involvement of Olympic volunteers. In this sense, and reinforcing this idea, this study aimed to analyse and measure the perception of sports volunteers regarding the motivations and expectations arising from their participation in the Rio 2016 Olympic Games. The study followed a quantitative-descriptive and inferential methodology, with a validated sample of 828 responses collected through a semi-structured questionnaire adapted from the original VMS-ISE motivation scale. The results point to a reinforcement of the perceived importance and value associated with participation in the Olympic Games that translate into high levels of motivation and satisfaction by most of the volunteers involved. The most valued factors were the feeling of pleasure promoted by the experience, the possibility of personal and professional development, the passion for the Olympic Games, and the passion for sport. The majority of the candidates validated the post-event expectations as having exceeded their initial ones, and 92.0% of the volunteers would participate in a similar event again. The study allows the reinforcement of sports volunteers intentions and expectations, while validating and confirming previous studies on the importance of motivation and personal development in a successful recruitment strategy that fosters regular and consolidated participation of previous volunteers.