bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1 transcription signature
Authors: Shen Dunxin , Vincent Alec , Udine Evan , Buhidma Yazead , Anoar Sharifah , Tsintzas Elli , Maeland Marie , Rademakers Rosa , Isaacs Adrian M , Frigerio Carlo , van Blitterswijk Marka , Lashley Tammaryn , Niccoli Teresa 
Published: November 2023

SummaryA G4C2 repeat expansion in the geneC9orf72(C9) is the most common genetic cause of sporadic and familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). What determines why cell death is triggered only in specific neuronal populations, while others remain ‘protected’ or are less susceptible to disease is still an open question. In particular, whether it is the transcriptional response to the accumulation of toxic insults or the initial cellular state that determines their vulnerability is still unknown.We have carried out a large-scale profiling of single cell transcriptional signatures throughout disease development in aDrosophilamodel of C9 repeat toxicity. This enabled us to monitor transcriptional shifts and track changes in cell populations during disease progression. We have identified neuronal populations which are depleted in response to C9 repeat expression, and therefore vulnerable to toxicity. On the other hand, other neuron types are resistant to toxicity, and maintain their cell number during disease progression. Our findings suggest that a major determinant of vulnerability is the transcriptional state of the cell before it is exposed to C9 repeat expression. We have identified a conserved transcriptional profile that is associated with resistance to C9 repeat toxicity. Neurons resistant to disease display a higher expression of genes involved in protein homeostasis, with Xbp1 identified as a crucial transcription factor determining neuronal vulnerability.
Planar cell polarity is essential for the architectural patterning of the mammalian biliary tree
Authors: Raab Michaela , Christodoulou Ersi , Krishnankutty Roopesh , Younger Nicholas T , Gournopanos Konstantinos , von Kriegsheim Alexander , Waddell Scott H , Boulter Luke 
Published: November 2023

AbstractIn the developing liver, bipotent epithelial progenitor cells known as hepatoblasts undergo lineage segregation to form the two major epithelial cell types, hepatocytes that constitute the bulk of the liver parenchyma and biliary epithelial cells (cholangiocytes) which comprise the bile duct, a complex tubular network which is critical for normal liver function. Notch and TGFβ signalling promote the formation of a sheet of biliary epithelial cells, the ductal plate that organises into discontinuous tubular structures. How these structures elongate and connect to form a continuous duct remains undefined. Here, we show that the planar cell polarity protein, VANGL2 is expressed late in intrahepatic bile duct development and patterns the formation of cell-cell contacts between biliary cells. The patterning of these cell contacts regulates the normal polarisation of the actin cytoskeleton within biliary cells and loss ofVangl2-function results in the abnormal distribution of cortical actin remodelling resulting in the failure of bile duct formation. Planar cell polarity is a critical step in the post-specification sculpture of the bile duct and is essential for establishing normal tissue architecture.
Cultivating loyalty in fast food through marketing cues
Authors: Hassan Hasliza , Lim Ser Chee , Rahman Muhammad Sabbir 
Published: November 2023

PurposeCultivating customer loyalty is extremely crucial for fast-food players to remain competitive in the industry. This research is discovering the path to cultivate customer loyalty through experience that is built based on auditory, gustatory, haptic, olfactory and visual cues.Design/methodology/approachQuantitative research has been conducted by distributing survey questionnaires to customers at selected fast-food restaurants in urban areas. The collected data has been analyzed by descriptive and structural equation modeling analysis.FindingsThe customers' loyalty to fast food can be cultivated through gustatory, haptic and olfactory cues. However, auditory and visual are not functioning as marketing cues to cultivate customer loyalty.Practical implicationsThe fast-food players may emphasize gustatory, haptic and olfactory marketing cues to cultivate customer loyalty. These cues can be shared through experience.Originality/valueThis study has discovered the potential ways to cultivate customer loyalty in dining at fast-food restaurants within the Malaysian market.
The effect of enabling performance measurement systems on team learning behaviour and team effectiveness
Authors: Toyosaki Hitomi 
Published: November 2023

Purpose
The purpose of this study is to investigate the impact of the enabling performance measurement systems (PMS) on non-managerial employees’ team learning behaviours (TLB) and team effectiveness (TE) when the PMS is used as an enabler.

Design/methodology/approach
A questionnaire survey was conducted with non-managerial employees in Japan and a total sample of 474 responses were collected. Partial least squares structural equation modelling using Smart-PLS was used for the analysis.

Findings
The results demonstrated that the design feature of global transparency in enabling PMS contributes to the enhancement of TE, with partial mediation through TLB. Furthermore, it was also evident that fostering TLB involves increasing the flexibility in PMS, specifically offering multiple options for collecting and aggregating performance information in various formats.

Originality/value
By examining the effects of the four features of enabling controls on TE and TLB, this study shows which features in an enabling PMS are important in motivating non-managerial employees at the operational level. The study not only fills a gap on the impact of enabling controls on non-managerial employees that has been under-researched but also makes an academic contribution in that it has deepened our understanding of four features that have not yet been fully elucidated.
Legal protection for gig workers' availability time: an empirical study of take-out platform riders in Beijing
Authors: Zhang Yanlong , Yan Dong 
Published: November 2023

PurposeThis empirical study of one of China's biggest take-out platforms during coronavirus disease 2019 (COVID-19) explores the legal rights and protections for gig workers' availability time.Design/methodology/approachThe study uses a quantitative survey and interviews of take-out platform riders, investigating the intrinsic features of working time and availability time. Labour law professionals and scholars are interviewed to verify the findings.FindingsThe availability time of take-out platform riders is difficult to define under the current legal working-time framework. There is a need for a specific method to define availability time, considering the multiple factors in gig-take-out-sector work. One option is to apply working-time regulations to availability time but to use a proportionality test to preserve flexibility whilst the platform offers protection to the riders during that time.Research limitations/implicationsPandemic-related travel restrictions limited the authors' study to one take-out platform in Beijing. Future studies should cover a wider geographical area and multiple take-out platforms.Originality/valueThe study uniquely evaluates the availability time of take-out platform riders to determine appropriate public policy and theoretical implications. It proposes a proportionality test regulating riders' availability. In particular, the workers being “at leisure” during availability time could mitigate the platform's liability for full remuneration or moderate the ceiling of working hours. The occupational health and safety of riders must be fully protected, as they are still “at the platform's disposal” at that time.
Job attributes of key Sri Lankan construction professionals in addressing the challenges associated with climate change
Authors: Sandaruwan Iddamalgoda Pathiranage Tharindu , Bihara Janardana Jayasinghe Arachchige , Manoharan Kesavan 
Published: November 2023

Purpose
Construction professionals are the major contributors to developing a sustainable construction industry, whereas architects, engineers and quantity surveyors are the key construction professionals who must play extraordinary roles in achieving better sustainable construction. Therefore, this study aims to identify the job attributes of key Sri Lankan construction professionals in addressing challenges associated with climate change.

Design/methodology/approach
The study adopted a mixed research approach. A literature review and preliminary semi-structured interviews were used to appraise the job roles of architects, engineers and quantity surveyors in addressing challenges associated with climate change. The data collected through the qualitative approach were used in an online questionnaire survey, and the findings were analysed using the relative index method.

Findings
The findings highlight that regardless of the knowledge of the professional category on green rating tools, carbon footprint, adaptation of renewable energies for the reduction of energy consumption, building information modelling-related applications and waste management concepts/practices are the foremost job attributes required for the key Sri Lankan construction professionals in addressing challenges associated with climate change.

Research limitations/implications
The results from this study provide a handful of guidance to construction industry professionals, national and international professional institutions, non-governmental organisations and other relevant authorities to address climate change within the built environment by identifying ways for improving the relevant key job attributes of construction industry professionals.

Originality/value
To the best of the authors’ knowledge, this is the first study that explores the job attributes of key Sri Lankan construction professionals in addressing the challenges associated with climate change.
Cultural events' service quality, satisfaction and loyalty: a case on an annual cultural diversity event in Borneo
Authors: Abdul Gapor Salfarina , Chin Chee Hua , Ngian Ek Tee , Wong Winnie Poh Ming , Kiew Jiet Ping , Toh Ting Ling 
Published: November 2023

PurposeThe purpose of this paper is to examine the hard and soft measures of service quality and visitors' satisfaction, which ultimately contribute to visitor loyalty to the destination, specifically in the context of the Borneo Cultural Festival (BCF) in Sibu, Sarawak (Malaysia).Design/methodology/approachThe study uses a quantitative research approach with 427 valid responses from domestic and international tourists of BCF and employs the cognitive-affective-conative theory to examine how the festival impacts visitor loyalty.FindingsThe findings indicate that both hard and soft measures significantly contribute to the service quality and visitor satisfaction at the BCF. Additionally, service quality and visitor satisfaction were found to positively influence destination loyalty, while the relationship between legibility and visitor satisfaction was not significant.Practical implicationsThe findings encourage the ministry and event organisers to adopt a destination event strategy that positions Sibu as an attractive event destination capable of attracting domestic and international tourists.Originality/valueThe findings of this study contribute to the existing body of knowledge on event tourism and destination loyalty by applying the cognitive-affective-conative theory. This study marks the first of its kind, analysing both the tangible (hard) and intangible (soft) measures of service quality and their impact on visitor satisfaction, ultimately influencing visitor loyalty to the destination, particularly in the context of the BCF in Sibu, Sarawak.
Improving shuttle services quality in VUCA world: evidence from the IT industry
Authors: Pitchaimani Kalpana , Zouadi Tarik , Lokesh K.S. , Sreedharan V. Raja 
Published: November 2023

PurposeAs the world is becoming more volatile and uncertain, organizations face much complexity in their daily operations. Further, there is a much ambiguity in business operations to achieve the effective utilization of resources. The work optimizes a novel constraint programming model approach of the utilization of shuttle services vehicle while considering cost savings, employee wellbeing and other real an Information Technology enabled service (ITES) industry constraints.Design/methodology/approachThe present work considers a novel extension of the vehicle routing problem related to the shuttle service operation in an ITES industry in VUCA context. Additionally, the model considers the women safety aspects, which engages the company to provide a security guard for women employees in the night shift.FindingsNumerical experiments were conducted on real instances data of ITES industrial partner. The results show that the vehicle utilization increased from 75% up to 96% while ensuring in parallel the wellbeing of employees and women safety during the night shift. Finally, the proposed model is converted to a decision support application allowing ITES partner to plan employees shuttle service operations efficiently.Originality/valueStudy has evaluated the shuttle services optimization for ITES industry using data from industrial which makes it a unique contribution to literature in shuttle operations. Further, the study used constraint programming to evaluate the vehicle utilization and security allocation, thereby introducing new parameter on security allocation in open VRP problem.
Entrepreneurial orientation and social performance of microfinance institutions in Indonesia
Authors: Riwu Kore Morrison Hendrik , Rokhim Rofikoh , Rachmawati Riani , Sudhartio Lily 
Published: November 2023

PurposeThe purpose of this research was to examine the influence of entrepreneurial orientation on social performance and the influence of social performance on financial performance of microfinance institutions (MFIs) in Indonesia. These tests use environmental dynamism as antecedents.Design/methodology/approachThe research was conducted on a sample of 235 CEOs/top leaders of MFIs spread across all provinces in Indonesia. Data collection used survey questionnaires. Data testing used SPSS version 25, and structural modeling used Amos version 25.FindingsThe findings show that entrepreneurial orientation significantly influences the social performance of MFIs in Indonesia. Entrepreneurial orientation does not influence financial performance but must go through social performance mediation. Social performance has a significant effect on financial performance. The importance of MFIs improves social performance (depth and breadth of reach) to improve financial performance.Practical implicationsMFIs need to increase social contribution and responsibility to improve social performance which will impact financial performance.Originality/valueEntrepreneurial orientation influence on financial performance goes through social performance. Social performance includes the depth of the reach to contribute to improving the quality of life of people experiencing poverty around the MFI's operations and the social responsibility of MFIs to the community through scholarships, free medical assistance, basic food assistance and building/renovating houses of worship and others.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-06-2023-0478
Safeguarding trust in a digital ecosystem
Authors: Aguiar Marcos , Kiderman Jeff , Shekar Harsha Chandra , Schilke Oliver 
Published: November 2023

Purpose
The purpose of this paper is to elaborate the significance of safeguards in digital ecosystems and their role in generating trust among participants. This paper argues that the right mix and number of safeguards are crucial for an ecosystem’s growth and success. It offers ecosystem orchestrators concrete guidelines for how to implement and monitor safeguards.

Design/methodology/approach
This research is based on both consulting experience and publicly available information on several digital ecosystems.

Findings
This research conceptualizes safeguards as precautionary mechanisms that mandate or promote desirable behavior in an effort to engender trust among ecosystem participants. Safeguards can take various forms, including passwords, escrow, user privacy controls, ratings and reviews and policies and contracts. Striking the right balance of safeguards – neither too few nor too many – is crucial for ecosystem orchestrators. This paper identifies the factors that determine the optimal mix of safeguards, including the power asymmetry between sellers and buyers, the sophistication of participants, the nature of transactions, the cost of negative outcomes and the cost-benefit tradeoff.

Originality/value
To the best of the authors’ knowledge, this study is one of the first to illuminate the relationship between safeguards and trust in the context of digital ecosystem. It is also one of the few attempts to provide managerial guidance for ecosystem designers trying to structure their platform for trust.
Overcoming the “blame game” in strategic climate communication: from decoupling accusations toward an arena-spanning agenda
Authors: Krämer Alexandra , Winkler Peter 
Published: November 2023

PurposeThe climate crisis presents a global threat. Research shows the necessity of joint communication efforts across different arenas—media, politics, business, academia and protest—to address this threat. However, communication about social change in response to the climate crisis comes with challenges. These challenges manifest, among others, in public accusations of inconsistency in terms of hypocrisy and incapability against self-declared change agents in different arenas. This increasingly turns public climate communication into a “blame game”.Design/methodology/approachStrategic communication scholarship has started to engage in this debate, thereby acknowledging climate communication as an arena-spanning, necessarily contested issue. Still, a systematic overview of specific inconsistency accusations in different public arenas is lacking. This conceptual article provides an overview based on a macro-focused public arena approach and decoupling scholarship.FindingsDrawing on a systematic literature review of climate-related strategic communication scholarship and key debates from climate communication research in neighboring domains, the authors develop a framework mapping how inconsistency accusations of hypocrisy and incapacity, that is, policy–practice and means–ends decoupling, manifest in different climate communication arenas.Originality/valueThis framework creates awareness for the shared challenge of decoupling accusations across different climate communication arenas, underscoring the necessity of an arena-spanning strategic communication agenda. This agenda requires a communicative shift from downplaying to embracing decoupling accusations, from mutual blaming to approval of accountable ways of working through accusations and from confrontation to cooperation of agents across arenas.
Measuring performance of farmer producer organisations using data envelopment analysis
Authors: Muniyoor Krishna , Pandey Rajan 
Published: November 2023

Purpose
Farmers producer organisations (FPOs) play the most crucial role in the agriculture supply chain system, aiming to redress the balance between farming and marketing activities of agricultural produce. The purpose of this study is to assess the performance of FPOs using data envelopment analysis (usually referred to as DEA) on 34 FPO units selected from the state of Rajasthan.

Design/methodology/approach
One of the most commonly used techniques to examine business performance is the application of DEA. The application of DEA requires the selection of inputs and outputs. This study takes three inputs and three outputs based on the insights drawn from the field survey. While the input variables consist of total assets, paid-up capital and the number of economic activities, the three output variables are turnover, net profit and number of members benefitted. Broadly, these variables encapsulate the operational performance of the business units.

Findings
This study’s findings reveal that the estimated relative efficiency score of the input-oriented CCR (Charnes, Cooper, and Rhodes) model ranges from 0.06 to 1. Interestingly, only one FPO has reported a relative efficiency (RE) score of one, whereas the remaining FPOs fall below the efficiency frontier. However, 15 FPOs report an RE score of one in the output-oriented CCR approach. Considering the estimates obtained in the input- and output-oriented BCC (Banker, Charnes and Cooper) models, this study found that about 20% of the FPOs report an efficiency score greater than 0.80. Moreover, three FPOs are on the frontier line. An examination of the scale efficiency score in the input-oriented model, 45% of the FPOs have an efficiency score greater than 0.80, whereas almost all FPOs achieve a scale efficiency score greater than 0.80 in the output-oriented model. Overall, the results imply that the FPOs should place greater emphasis on the efficient utilisation of the inputs to enhance the overall business performance and productivity.

Research limitations/implications
The findings of this study provide vital insights into the specific inputs and outputs that determine the performance efficiency of FPOs and identify the potential areas for improving the existing inefficient FPOs.

Originality/value
This study contributes to the repository of the existing empirical studies in three distinct ways. First, the authors hardly found any previous studies that quantitatively assess the business performance of FPOs using the DEA technique. Second, the effort to identify the slacks associated with each input and output variable in input- and output-oriented models gives insights on improvable areas for inefficient FPOs. Third, the authors attempt to demystify the empirical obfuscations by highlighting the major challenges FPOs face in the state of Rajasthan.
Enhancing digital service communication strategies
Authors: Lee Seonjeong Ally , Oh Haemoon 
Published: November 2023

Purpose
Based on stimulus-organism-response theory, this study aims to explore how digital service communication strategies affected customers’ e-service agent use intentions through perceived warmth and competence.

Design/methodology/approach
A 2 × 2 scenario-based experiment was conducted to test the proposed relationships.

Findings
Findings indicated when a high-authority conversation party was engaged in digital service communications, customers showed higher e-service agent use intentions through perceived warmth and competence in an emoji-presence conversation style.

Originality/value
To the best of the authors’ knowledge, this study is the first to explore the effects of digital service communication strategies on customers’ internal and behavioral responses.