bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erdoğan's Bid to Re‐Establish Dominance After His Pyrrhic Victory
Authors: Özcan Nihat Ali , İpek Pınar 
Published: November 2023

AbstractThis article examines President Recep Tayyip Erdoğan's actions since he barely survived the May 2023 election. It argues that although Erdoğan's authoritarian personality and conservative Islamist ideology drive his foreign policy, his pyrrhic victory and Turkey's economic problems have forced him to rebalance the country's regional and bilateral relations with Arab and Western states. The analysis first explains Erdoğan's re‐election strategy to demonstrate his authoritarian personality and desire to retain power. It then shows how the election results and Turkey's economic challenges have shaped Erdoğan's pragmatic U‐turns in foreign policy since the campaign. From there, the article assesses the president's near‐term strategies for municipal elections and other challenges in domestic politics. It concludes that Erdoğan's overconfidence is constrained by Turkish economic stresses, though the direction of foreign policy remains unclear.
LIPUS can promote osteogenesis of hPDLCs and inhibit the periodontal inflammatory response via TLR5
Authors: Li Ping , Zhang Zhipeng , Liu Jingjing , Xue Hui 
Published: November 2023

AbstractIn this study, we isolated human periodontal ligament cells (hPDLCs) to find the optimal time of LIPUS stimulation and to explore how LIPUS affects inflammatory and osteogenic responses in hPDLCs in an inflammatory environment. The target molecules of LIPUS were identified by high‐throughput sequencing. RT–qPCR and WB were used to detect how LIPUS affected the expression of related genes in TNFα‐induced inflammation. The expression of ROS and inflammatory factors was detected by flow cytometry. Immunohistochemistry was used to further verify gene expression in rats. hPDLCs were isolated successfully. The optimal LIPUS stimulation condition was 45 mW/cm2 for 30 min and continued for 3 days, and this intensity significantly promoted the osteogenesis and mineralization of hPDLCs. LIPUS significantly inhibited the upregulation of IL‐6 and ROS, increased the percentage of cells in the G2 phase, inhibited cell apoptosis, and inhibited the upregulation of TLR5 expression in an inflammatory environment. LIPUS can effectively restrain the inflammation and oxidative stress response of hPDLCs and promote osteogenesis in an inflammatory environment. LIPUS inhibited the periodontal inflammatory response through TLR5 in hPDLCs and dental pulp.
Uncovering epigenetic and transcriptional regulation of growth in Douglas‐fir: identification of differential methylation regions in mega‐sized introns
Authors: Vu Giang Thi Ha , Cao Hieu Xuan , Hofmann Martin , Steiner Wilfried , Gailing Oliver 
Published: November 2023

SummaryTree growth performance can be partly explained by genetics, while a large proportion of growth variation is thought to be controlled by environmental factors. However, to what extent DNA methylation, a stable epigenetic modification, contributes to phenotypic plasticity in the growth performance of long‐lived trees remains unclear. In this study, a comparative analysis of targeted DNA genotyping, DNA methylation and mRNAseq profiling for needles of 44‐year‐old Douglas‐fir trees (Pseudotsuga menziesii (Mirb.) Franco) having contrasting growth characteristics was performed. In total, we identified 195 differentially expressed genes (DEGs) and 115 differentially methylated loci (DML) that are associated with genes involved in fitness‐related processes such as growth, stress management, plant development and energy resources. Interestingly, all four intronic DML were identified in mega‐sized (between 100 and 180 kbp in length) and highly expressed genes, suggesting specialized regulation mechanisms of these long intron genes in gymnosperms. DNA repetitive sequences mainly comprising long‐terminal repeats of retroelements are involved in growth‐associated DNA methylation regulation (both hyper‐ and hypomethylation) of 99 DML (86.1% of total DML). Furthermore, nearly 14% of the DML was not tagged by single nucleotide polymorphisms, suggesting a unique contribution of the epigenetic variation in tree growth.
Genome‐wide identification of Avicennia marina aquaporins reveals their role in adaptation to intertidal habitats and their relevance to salt secretion and vivipary
Authors: Guo Zejun , Wei Mingyue , Xu Chaoqun , Wang Lu , Li Jing , Liu Jingwen , Zhong Youhui , Chi Bingjie , Song Shiwei , Zhang Ludan , Song Lingyu , Ma Dongna , Zheng Hai‐Lei 
Published: November 2023

AbstractAquaporins (AQPs) regulate the transport of water and other substrates, aiding plants in adapting to stressful environments. However, the knowledge of AQPs in salt‐secreting and viviparous Avicennia marina is limited. In this study, 46 AmAQPs were identified in A. marina genome, and their subcellular localisation and function in transporting H2O2 and boron were assessed through bioinformatics analysis and yeast transformation. Through analysing their expression patterns via RNAseq and real‐time quantitative polymerase chain reaction, we found that most AmAQPs were downregulated in response to salt and tidal flooding. AmPIP (1;1, 1;7, 2;8, 2;9) and AmTIP (1;5, 1;6) as salt‐tolerant candidate genes may contribute to salt secretion together with Na+/H+ antiporters. AmPIP2;1 and AmTIP1;5 were upregulated during tidal flooding and may be regulated by anaerobic‐responsive element and ethylene‐responsive element cis‐elements, aiding in adaptation to tidal inundation. Additionally, we found that the loss of the seed desiccation and dormancy‐related TIP3 gene, and the loss of the seed dormancy regulator DOG1 gene, or DOG1 protein lack heme‐binding capacity, may be genetic factors contributing to vivipary. Our findings shed light on the role of AQPs in A. marina adaptation to intertidal environments and their relevance to salt secretion and vivipary.
Penile keloid formation post‐circumcision: A case series and review of literature
Authors: Tam Idy , Sun Lillian , Patel Anish , Woo Lynn , Weaver John , Shah Sonal D. 
Published: November 2023

AbstractThe formation of penile keloid after circumcision is an uncommon complication. Herein, we report two pediatric cases of large circumferential keloids that developed post‐circumcision and were successfully treated by surgical excision and intralesional triamcinolone injections. In addition, we provide a comprehensive review of the reported cases of penile keloids that developed after circumcision in the literature to highlight the various presentations, treatment options, and outcomes for this condition.
Swedish stakeholders' views of the preparatory work needed before introducing the nurse practitioner role in municipal healthcare–A focus group study
Authors: Ljungbeck Birgitta , Carlson Elisabeth , Forss Katarina Sjögren 
Published: November 2023

AbstractBackgroundThe nurse practitioner role has become important globally in handling the growing healthcare needs of older adults with chronic diseases. Nevertheless, research shows that introducing the role is a complex process, and more studies are needed to prepare for its introduction into different healthcare contexts, such as municipal healthcare.AimThe aim is to investigate what Swedish stakeholders identify as the preparatory work needed before introducing the nurse practitioner role into municipal healthcare.MethodsData were collected through four focus group interviews conducted virtually on the TEAMS digital platform, with three to six participants in each group and 18 participants total. The transcribed interviews were analysed using a six‐step thematic approach: familiarisation with the data, coding the data, generating initial themes, reviewing themes, defining and naming the themes and producing the report.FindingsThe findings are divided into two main themes, each with two sub‐themes. In the first, clarifying why the nurse practitioner role is needed, participants stressed the importance of having a clear intention for introducing the role. The second, ensure a national framework to bolster the introduction at the local level, demonstrates the need for collaboration among national actors to clarify the role's mandate and authority before its introduction.ConclusionsAdding the nurse practitioner role to municipal healthcare can help increase the supply of nursing competence and the quality of patient care, but preparation for introducing the role requires extensive work. The development of the nurse practitioner role requires decision‐makers and leaders to take primary responsibility for its introduction. This study can support countries in the early phase of developing the nurse practitioner role by identifying both best practices and pitfalls.
Evolution from shallow‐water deltas to fluvial fans in lacustrine basins: A case study from the Middle Jurassic Shaximiao Formation in the central Sichuan Basin, China
Authors: Yang Tian , Li Xiaofang , Yang Yu , Wen Long , Cao Zhenglin , Wang Xiaojuan , Zhang Shaomin , Liang Qiangshao 
Published: November 2023

AbstractDistinguishing between shallow‐water delta and fluvial fan deposits in the subsurface of lacustrine basins is challenging due to their similar depositional characteristics and distribution patterns. This study focuses on the Middle Jurassic Shaximiao Formation in the central Sichuan Basin using core observations, seismic analyses, petrology analyses, zircon analyses, palaeoclimate indicators and palaeocurrent analyses to address this issue. Fifteen sedimentary lithofacies and eight lithofacies associations were established, corresponding to channelized fluvial deposits, non‐channelized fluvial deposits and shallow‐water delta deposits. Shallow‐water deltas are dominated by channels and mouth‐bar complexes with grey, red and green interbedded mudstone. Shingled seismic reflection, green mud clasts, small burrows and wave ripples are common with occasional palaeosols. Fluvial fans are dominated by channels and crevasse‐splays with pink colour and accompanied by red coloured floodplain deposits. Bright spot seismic reflection, red mud clasts, big burrows, current ripples and palaeosols are common. The increased uplift of the Dabashan Mountains controls the palaeocurrent direction, promoting the evolution from a shallow‐water delta in relatively humid environments to a fluvial fan in relatively arid environments. The channel widths in shallow‐water deltas are wider than those in fluvial fans, whereas the opposite applies for the channel amalgamation rate. Highly frequent channel‐width variations are controlled by short‐cycle climate fluctuation, corresponding to chemical index of alteration value fluctuations in different sandstone groups. The channel width in the relatively humid environments is wider than that in arid environments for both shallow‐water deltas and fluvial fans. It is likely that the sedimentary evolution from shallow‐water deltas to fluvial fans is relatively common in lacustrine basins in relatively arid environments with wide and gentle slope landforms.
Differences in toll‐like receptor ligand‐induced cytokine concentrations before and after solid organ transplantation: A prospective, observational cohort study in a clinical setting
Authors: Møller Dina Leth , Sørensen Søren Schwartz , Perch Michael , Gustafsson Finn , Hald Annemette , Knudsen Andreas Delhbæk , Abdulovski Ranya , Arentoft Nicoline Stender , Lundgren Jens , Rasmussen Allan , Ostrowski Sisse Rye , Nielsen Susanne Dam 
Published: November 2023

AbstractReliable methods to assess immune function after solid organ transplantation (SOT) are needed to guide dosing of immunosuppression. We hypothesized that toll‐like receptor ligand‐induced cytokine concentrations would decrease post‐transplantation due to the use of immunosuppressive medication. Furthermore, we hypothesized that induced cytokine concentrations pre‐transplantation would be higher in recipients with episodes of acute rejection post‐transplantation due to underlying immunological dispositions. We aimed to investigate toll‐like receptor ligand‐induced cytokine concentrations by TruCulture©, a standardized immunoassay, in SOT recipients before and 3 months after SOT and explored associations with methylprednisolone‐treated acute rejections. We conducted a prospective, observational cohort study including 123 participants (67 liver, 32 kidney and 24 lung transplant recipients). Whole blood was stimulated for 22 h with: (A) Lipopolysaccharide (LPS), (B) Resiquimod, (C) Polyinosinic:polycytidylic acid (Poly I:C) and (D) a blank control. Cytokine concentrations (TNF‐α, IL‐1β, IL‐6, IL‐8, IL‐10, IL‐12p40, IL‐17A, IFN‐α and IFN‐γ) were measured by Luminex. 30 participants developed methylprednisolone‐treated acute rejection at a median of 9 days (IQR 5–17) post‐SOT. We found that all induced cytokine concentrations decreased post‐SOT except from LPS‐induced and Poly I:C‐induced IL‐10. The induced cytokine concentration pre‐transplantation did not differ in recipients with or without acute rejection. In conclusion, the induced cytokine concentrations decreased for all stimuli post‐SOT, except the anti‐inflammatory cytokine IL‐10. Importantly, recipients developing early acute rejection did not differ in induced cytokine concentrations pre‐SOT. Thus, the use of a standardized assay in SOT is feasible in a clinical setting and may provide important information on the immune function post‐SOT.
Forms of fiscal governance in the Euro Area – An update
Authors: Catania Moira , Baimbridge Mark , Litsios Ioannis 
Published: November 2023

AbstractDespite the common Euro Area (EA) requirements, we find notable differences in the quality of fiscal governance among the 19 member states. Moreover, characteristics of the delegation approach, which have been largely ignored in the EA fiscal governance framework, remain important in various member states. Using a two‐way fixed effects panel data model for the EA countries during 2006–2018, we find that the delegation approach can be effective to improve the fiscal position. On the other hand, the imposition of centrally mandated common rules‐based reforms has not taken into account the national political, social and institutional setting, and this may have also affected their effectiveness to achieve fiscal discipline. Our findings thus suggest a reconsideration of the one‐size‐fits‐all, rules‐based approach to fiscal governance in the EA.
Rapid screening for suicide risk: An algorithmic approach
Authors: Dodge Matthew C. , Hicks Adam D. , McCord David M. 
Published: November 2023

AbstractIntroductionIn the United States, primary medical care settings are the first accessed resource for both medical and behavioral health care. Thus, there is a clear need for accurate and efficient behavioral health screening in this setting, including routine surveillance screening for suicide risk. The Multidimensional Behavioral Health Screen (MBHS), a broadband but very brief screening tool developed specifically for primary care, has been updated to include an algorithm that classifies suicide risk based on the interpersonal‐psychological theory of suicide, and associated interview and decision framework. This study aims to evaluate the predictive accuracy of the new MBHS 2.0 suicide risk algorithm, with actual risk determined by clinical suicide risk interview.MethodData were collected as part of a larger study that, overall, included 551 college student participants. Of these, 309 completed the MBHS 2.0 and the clinical suicide risk interview, the two measures reported here. The final participant count was 299 following the removal of incomplete or invalid cases. Predicted suicide risk as determined by the MBHS 2.0 (Low, Mild, At least Moderate) was compared to actual risk as determined by clinical interview (Low, Moderate, Severe, Extreme).ResultsUtilizing chi‐square analyses, data show a significant association between the predicted suicide risk category based on the MBHS 2.0 algorithm and the actual risk category based on the semi‐structured clinical interview. Furthermore, classification analyses suggest that primary care providers will be able to confidently assess the suicide risk level for the majority of their patients when using the MBHS.ConclusionFindings suggest that the MBHS 2.0 can be an accurate and efficient tool for use by primary care providers in classifying suicide risk. Future research will be useful to evaluate the utility of the suicide risk algorithm among primary care populations.
Observation on cadavers and through ultrasonography using a 2 mm needle length for intradermal injections
Authors: Yi Kyu‐Ho , Lee Brian , Kim Michael James , Lee Seo‐Hyun , Hidajat Inneke Jane , Lim Ting Song , Kim Hyoung Moon , Kim Jin‐Hyun 
Published: November 2023

AbstractBackgroundAn intradermal injection is a medical procedure that involves administering a small amount of medication or substance into the dermal layer of the skin. This research focused on identifying the most suitable injection needle for precise intradermal administration of skin boosters.MethodsThe study involved conducting intradermal injections on four cadavers and participants using a 2 mm length, 34‐gauge needle (N‐Finders, Inc., South Korea). During the cadaveric study, the polynucleotide prefilled syringe was dyed green, and an anatomist performed dissections, removing only the skin layer. Ultrasonographic observations were carried out to ensure accurate intradermal injection placement.ResultsIn all four cadavers, the facial injections at the anterior cheek region were precisely administered intradermally at a 30‐degree injection angle. However, the 90‐degree injection was found just below the dermal layer upon skin layer removal.DiscussionThe findings suggest that using a 2 mm needle length allows for easy and convenient intradermal injections.
Sequential Ahmed valve implantation after primary implant surgery in two dogs
Authors: Lee Songhui , Kim Hyun‐ah , Seo Kangmoon , Kang Seonmi 
Published: November 2023

AbstractObjectiveTo report the outcomes of sequential Ahmed valve implantation in two dogs with uncontrolled intraocular pressure (IOP) after primary Ahmed valve implantation.Animals StudiedA 6‐year‐old castrated male American Cocker Spaniel (case 1) and a 12‐year‐old spayed female mixed‐breed dog (case 2) presented with glaucoma management in the left eyes of both dogs.ProceduresPrimary Ahmed valve implantation was performed because of uncontrolled IOP despite antiglaucoma medications used in both dogs. The IOP was maintained within the normal range for 14 and 2 months after surgery in cases 1 and 2, respectively. In both cases, the IOP gradually increased, which was assumed to be caused by bleb fibrosis. In particular, in case 2, one bleb revision surgery was performed during that period, but it was unsuccessful. Therefore, we decided to perform sequential implantation surgery.ResultsIn case 1, hyphema occurred the day after sequential surgery and resolved with anti‐inflammatory treatment. In case 2, it occurred immediately after the surgery and resolved after surgical blood clot removal. IOP remained below 15 mmHg, and menace response was positive until 40 and 23 months after the sequential surgery in cases 1 and 2, respectively. As a long‐term complication, cataracts occurred at 17 months in case 1 and 10 months in case 2.Conclusions and Clinical RelevanceSequential implantation surgery in the same eye could be an effective alternative for long‐term IOP management and vision maintenance. A better understanding of complications and appropriate postoperative management is essential for better outcomes.
Three‐dimensional versus two‐dimensional laparoscopy for cholecystectomy in a canine cadaveric study
Authors: Azuma Kazushi , Monnet Eric 
Published: November 2023

AbstractObjectiveTo compare the effect of three‐dimensional (3D) and two‐dimensional (2D) laparoscopy on surgical time and intraoperative complications during cholecystectomies in canine cadavers.Study designExperimental prospective study.AnimalsTwelve canine cadavers.MethodsThe laparoscopic cholecystectomies were performed in canine cadavers with four cannulas and with either 2D or 3D cameras by a single surgeon. The following surgical times were recorded: time from insertion of laparoscopic instruments to first endoclip placement, time from first endoclip placement to second endoclip placement, time from second endoclip placement to complete gall bladder dissection, and total surgical time. The cystic duct length distal to the first endoclip, intraoperative complications, and the amount of liver attached to the gall bladder were also recorded.ResultsTime from the insertion of the instruments to the application of the first endoclip was shorter for the 3D group than for the 2D group (p = .016). Other surgical times were not different between groups. There was no difference in the cystic duct length distal to the first endoclip, intraoperative complications, or the amount of liver attachment.ConclusionThree‐dimensional laparoscopy shortened the time from insertion of the laparoscopic instruments to placement of the first endoclip. However, total surgical time was not affected by the type of camera in laparoscopic cholecystectomy.Clinical significanceThree‐dimensional laparoscopy may be beneficial when performing procedures requiring enhanced spatial orientation. However, this technique did not shorten the total surgical time in this cadaveric study. Further studies in a clinical setting are necessary for the optimization of the future use of 3D laparoscopy.
A Product Life Cycle Approach to Medical Device Development for Low-Resource Settings - A Systematic Literature Review
Authors: Overhoff Milena , Lumpe Thomas S. , Shea Kristina 
Published: November 2023

Abstract
Rural areas in most of the world lack functional medical devices for essential care. Even though devices exist on the global market, they are often not accessible in low-resource settings (LRS). One evident reason is the high price that many health facilities in rural areas cannot afford. However, even after the initial purchase, an estimated 70–90% of the devices are not operational. The core of this problem is often that the existing technologies were not designed for these settings, but for high-income countries with efficient healthcare systems and abundant resources. As such, the challenges for medical devices in LRS can vary significantly from high-income countries and span the whole product life cycle. This paper aims to synthesize the existing knowledge from literature about these challenges and to identify the product life cycle stages that provide the greatest potential for further research. Through a systematic keyword search with multiple exclusion rounds using the PRISMA method, 26 relevant papers are identified and analyzed according to the product life cycle stages they cover. The results reveal a lack of knowledge especially about the final life cycle stages, i.e. recycling and disposal, and a wide range of challenges for the use, consumption and maintenance stages as well as the marketing and sales of devices. The identified gaps in generalized knowledge provide a call to action for researchers and medical device developers to investigate and determine critical areas to make high quality medical devices more accessible and sustainable in LRS.