bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real Argentinian Food. Tensions and Conflicts in Value-Added Processes of Products to Commercialization and Tourism
Authors: Tolosa Sandra , Winter Cecilia Pérez 
Published: February 2024

Summary

Wine and
dulce de leche
(Caramel sauce) were recognised as cultural national food heritage in Argentina due to their importance in daily consumption and gastronomic identity. The formal recognition aligns with global food valorisation processes, such as the United Nations Educational, Scientific and Cultural Organization’s (UNESCO) immaterial heritage and the importance of gastronomic tourism. Also, public policies in different countries seek to add value to food and beverages in order to foster the development of rural areas, favour tourism commercialisation, strengthen local identities and enhance traditional/ancestral knowledge. These show the symbolic and economic value of food.

In this context, several types of formal certifications and commodification processes, which recognise territorial anchorage, of how certain food is produced and consumed may lead to its standardisation, homogenisation or monopolisation, generating various tensions. Hence, we question the relationship between those who promote value-adding initiatives, how farm producer communities participate in them, which sectors or actors really benefit from these processes and what tensions may arise from them. We will address these questions by reconstructing and analysing the heritage and tourism valorisation of high-altitude wine in the Calchaquíes Valleys area and
dulce de leche
production in the province of Buenos Aires.

Information
© The Authors 2024
Looking Behind the Stage in a Beach Paradise: Taganga, Colombia
Authors: Quiroga Nieto Freddy Giovanny , Garavito González Luis Leonardo , Bassols Gardella Narcís 
Published: February 2024

Summary
This case study looks beyond the clichés of paradise destinations in the Caribbean through an in-depth exploration of one of the beach destinations in this region. Extensive research performed on-site reveals the main junctures of the place’s history in the scheme of tourism development. The once isolated fishing community of Taganga on the Caribbean coast of Colombia is examined via participant and non-participant observation, and with semi-structured interviews that uncover the dynamics of negotiations and conflicts between the community, visitors, local authorities, and tourist industry. The changes in the nature of visitor markets are also reported as they relate to the actions of external and internal stakeholders. The effects of these changes over time are evident in the community’s shifting economy as well as in the destination’s environment. These mirror shifts at local, national, and international levels, and the authors will discuss whether they indicate advancing towards more value and higher experiential levels, as is posited by the literature.

Information
© The Authors 2024
Punta Arenas: Challenges and Opportunities of Adventure, Sustainability, and Heritage in Patagonian Tourism
Authors: Santos Eleonora 
Published: February 2024

Summary
This case study explores Punta Arenas’ tourism dynamics, emphasizing strategic approaches, diverse Patagonian products, and challenges. It offers a roadmap for sustainable growth and prosperity while providing stakeholders with valuable insights. Driven by an exploration of the region’s rich heritage and global tourism significance, the study focuses on personalization, sustainability, and adventure safety. Utilizing qualitative research with tourist entertainment companies, findings illuminate operators’ alignment with global trends. Despite challenges, growth opportunities highlight targeted navigation, exploration, client understanding, and strategic marketing. The study’s threefold implications advocate for collaborative networks, diverse visitor engagement shaping the region’s narrative, and integrated policy making for sustainability. The study underscores a roadmap that emphasizes innovation, inclusivity, and preservation, contributing to enduring prosperity for this extraordinary destination. Its insights, guide stakeholders towards sustainable growth, social harmony, and environmental conservation.

Information
© The Author 2024
Unique gap-related SERS behaviors of p-aminothiophenol molecules absorbed on TiO2 surface in periodic TiO2/Ni nanopillar arrays
Authors: Wu Zhijun , Zheng Chunfang , Lin Qi , Fu Qun , Zhao Huaping , Lei Yong 
Published: February 2024

Abstract
We observed a unique interpillar gap-related surface-enhanced Raman scattering (SERS) behavior of p-aminothiophenol (PATP) molecules from periodic TiO2 nanopillar arrays with three gap sizes of 191, 297 and 401 nm, which is completely different from that on Ag and Ni nanopillar arrays. Especially, the gap-size-dependent charge-transfer (CT) resonance enhancement from TiO2/Ni has been indicated through comparisons of variation trend of SERS intensities with inter-pillar gap size between TiO2/Ni and Ag/TiO2/Ni as well as Ni nanoarrays, and been confirmed by spectra of ultraviolet–visible absorption and photoluminescence. Results demonstrate that the CT resonance enhancement is more susceptible to the change of the gap size compared with the surface plasmon resonance (SPR) enhancement in TiO2/Ni nanoarrays. Hence, SPR and CT enhancement showing different variation trend and rate with the gap size that leads to a different relative contribution of CT resonance to the overall SERS enhancement as gap size changes, and consequently results in a unique gap-related SERS behavior for TiO2/Ni nanoarrays. The present study is not only helpful for investigating SERS mechanism for semiconductors but also providing a method to design and optimize periodic metal/semiconductor SERS substrates in a controllable way.
Bubble nucleation in the two-flavor quark-meson model*
Authors: Wang 汪 Junrong 俊荣 , Yu 余 Ziwan 紫琬 , Mao 毛 Hong 鸿 
Published: February 2024

Abstract
We investigate the dynamics of a first-order quark-hadron transition via homogeneous thermal nucleation in the two-flavor quark-meson model. The contribution of the fermionic vacuum loop in the effective thermodynamics potential and phase diagram, together with the location of the critical endpoint (CEP), is obtained in the temperature and chemical potential plane. For weak and strong first-order phase transitions, by taking the temperature as a variable, the critical bubble profiles, evolutions of the surface tension, and saddle-point action in the presence of a nucleation bubble are numerically calculated in detail when fixing the chemical potentials at

and

. Our results show that the system could be trapped in the metastable state for a long time as long as the temperature is between the metastable region characterized by the up and low spinodal lines. Moreover, the surface tension at criticality will rise to approximately

when the chemical potential is very high. Such a small surface tension value would favor a mixed phase in the cores of compact stars and may have an important implication in astrophysics.
Multiplicity dependence of the freezeout parameters in high energy hadron-hadron collisions*
Authors: Ajaz Muhammad , Shehzad Majid , Waqas Muhammad , Alrebdi Haifa I. , Ayaz Ahmad Mohammad , Jagnandan Antalov , Jagnandan Shawn , Badshah Murad , Baker Jalal Hasan , Mosawir Quraishi Abdul 
Published: February 2024

Abstract
We examined the transverse momentum (

) spectra of various identified particles, encompassing both light-flavored and strange hadrons (

,

,

, ϕ,

,

,

, and

), across different multiplicity classes in proton-proton collisions (p-p) at a center-of-mass energy of

TeV. Utilizing the Tsallis and Hagedorn models, parameters relevant to the bulk properties of nuclear matter were extracted. Both models exhibit good agreement with experimental data. In our analyses, we observed a consistent decrease in the effective temperature (T) for the Tsallis model and the kinetic or thermal freeze-out temperature (

) for the Hagedorn model, as we transitioned from higher multiplicity (class-I) to lower multiplicity (class-X). This trend is attributed to the diminished energy transfer in higher multiplicity classes. Additionally, we observed that the transverse flow velocity (

) experiences a decline from class-I to class-X. The normalization constant, which represents the multiplicity of produced particles, was observed to decrease as we moved toward higher multiplicity classes. While the effective and kinetic freeze-out temperatures, as well as the transverse flow velocity, show a mild dependency on multiplicity for lighter particles, this dependency becomes more pronounced for heavier particles. The multiplicity parameter for heavier particles was observed to be smaller than that of lighter particles, indicating a greater abundance of lighter hadrons compared to heavier ones. Various particle species were observed to undergo decoupling from the fireball at distinct temperatures: lighter particles exhibit lower temperatures, while heavier ones show higher temperatures, thereby supporting the concept of multiple freeze-out scenarios. Moreover, we identified a positive correlation between the kinetic freeze-out temperature and transverse flow velocity, a scenario where particles experience stronger collective motion at a higher freeze-out temperature. The reason for this positive correlation is that, as the multiplicity increases, more energy is transferred into the system. This increased energy causes greater excitation and pressure within the system, leading to a quick expansion.
Black hole shadows in Einstein-Bel-Robinson gravity*
Authors: Hamil B. , Lütfüoğlu B. C. 
Published: February 2024

Abstract
Gravity models given by higher-order scalar curvature corrections are believed to bear important consequences. Einstein-Bel-Robinson (EBR) gravity with quartic curvature modification motivated Sajadi et al. to explore static spherically symmetric black hole solutions using perturbative methods. In this study, inspired by their work, we investigate AdS black hole shadows in EBR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presence of plasma, because the black holes are thought to be surrounded by a medium that changes the geodesic of photons.
Unraveling the directional relationship of sleep and migraine-like pain
Authors: Lillo Vizin Robson C , Kopruszinski Caroline M , Redman Paula M , Ito Hisakatsu , Rau Jill , Dodick David W , Navratilova Edita , Porreca Frank 
Published: February 2024

Abstract
Migraine and sleep disorders are common co-morbidities. Patients frequently link their sleep to migraine attacks suggesting a potential causal relationship between these conditions. However, whether migraine pain promotes or disrupts sleep or whether sleep disruption can increase the risk of migraine remains unknown. We assessed the potential impact of periorbital allodynia, a measure consistent with migraine-like pain, from multiple preclinical models on sleep quantity and quality. Additionally, we evaluated the possible consequences of sleep deprivation in promoting susceptibility to migraine-like pain. Following the implantation of electroencephalogram/electromyography electrodes to record sleep, mice were treated with either single or repeated systemic injections of nitroglycerin at the onset of their active phase (i.e. nocturnal awake period). Neither single nor repeated nitroglycerin affected the total sleep time, non-rapid eye movement sleep, rapid eye movement sleep, sleep depth or other measures of sleep architecture. To account for the possible disruptive effects of the surgical implantation of electroencephalogram/electromyography electrodes, we used immobility recordings as a non-invasive method for assessing sleep-wake behaviour. Neither single nor repeated nitroglycerin administration during either the mouse sleep (i.e. daylight) or active (i.e. night) periods influenced immobility-defined sleep time. Administration of an inflammatory mediator mixture onto the dura mater at either sleep or active phases also did not affect immobility-defined sleep time. Additionally, inhalational umbellulone-induced migraine-like pain in restraint-stressed primed mice did not alter immobility-defined sleep time. The possible influence of sleep disruption on susceptibility to migraine-like pain was evaluated by depriving female mice of sleep over 6 h with novel objects, a method that does not increase circulating stress hormones. Migraine-like pain was not observed following acute sleep deprivation. However, in sleep-deprived mice, subthreshold doses of systemic nitroglycerin or dural calcitonin gene-related peptide induced periorbital cutaneous allodynia consistent with migraine-like pain. Our data reveal that while migraine-like pain does not significantly disrupt sleep, sleep disruption increases vulnerability to migraine-like pain suggesting that a therapeutic strategy focused on improving sleep may diminish migraine attacks.
Is there a refugee gap? Evidence from over a century of Danish naturalizations
Authors: Boberg-Fazlić Nina , Sharp Paul 
Published: February 2024

Abstract
The “refugee gap”—the difference in the economic status of refugees relative to other migrants might be due to the experience of being a refugee or to government policy. In Denmark before the Second World War, refugees were not treated differently from other migrants, motivating our use of a database of the universe of Danish naturalizations between 1851 and 1960. We consider labor market performance and find that immigrants leaving conflicts fared no worse or even performed better than other migrants within this relatively homogeneous sample of those who attained citizenship. This suggests that refugees and other migrants might be given the same rights if policy aims to ensure economic success.
K2R: Tinted de Bruijn Graphs implementation for efficient read extraction from sequencing datasets
Authors: Vandamme Léa , Cazaux Bastien , Limasset Antoine 
Published: February 2024

AbstractThe analysis of biological sequences often depends on reference genomes; however, achieving accurate assemblies remains a significant challenge. As a result, de novo analysis directly from raw sequencing reads, without pre-processing, is frequently a more practical approach. A common need across various applications is the ability to identify reads containing a specifick-mer within a dataset. Thisk-mer-to-read association is critical in multiple contexts, such as genotyping, bacterial strain resolution, profiling, data compression, error correction, and assembly. While this challenge appears similar to the extensively researched colored de Bruijn graph problem, resolving it at the read level is prohibitively resource-intensive for practical applications. In this work, we demonstrate its tractable resolution by leveraging reasonnable assumptions for genome sequencing dataset indexing. To tackle this challenge, we introduce the Tinted de Bruijn Graph concept, an altered version of the colored de Bruijn graph where each read in a sequencing dataset acts as a distinct source. We developed K2R, a highly scalable index that implements this framework efficiently. K2R’s performance, in terms of index size, memory footprint, throughput, and construction time, is benchmarked against leading methods, including hashing techniques (e.g., Short Read Connector and Fulgor), full-text indexing (e.g., Movi and Themisto) across various datasets. To demonstrate K2R’s scalability, we indexed two human datasets from the T2T consortium. The 126X coverage ONT dataset was indexed in 9 hours using 61GB of RAM, resulting in a 30GB index. Similarly, the 56X coverage HiFi dataset was indexed in less than 5 hours using 39GB of RAM, producing a 20.5GB index. Developed in C++, the K2R index is open-source and available on GitHub athttp://github.com/LeaVandamme/K2R.
Quantifying the impact of cascade inequalities: a modelling study on the prevention impacts of antiretroviral therapy scale-up in Eswatini
Authors: Knight Jesse , Ma Huiting , Sithole Bheki , Khumalo Lungile , Wang Linwei , Schwartz Sheree , Muzart Laura , Matse Sindy , Mnisi Zandile , Kaul Rupert , Escobar Michael , Baral Stefan , Mishra Sharmistha 
Published: February 2024

AbstractBackgroundInequalities in the antiretroviral therapy (ART) cascade across subpopulations remain an ongoing challenge in the global HIV response. Eswatini achieved the UNAIDS 95-95-95 targets by 2020, with differentiated programs to minimize inequalities across subpopulations, including for female sex workers (FSW) and their clients. We sought to estimate additional HIV infections expected in Eswatini if cascade scale-up had not been equal, and under which epidemic conditions these inequalities could have the largest influence.MethodsDrawing on population-level and FSW-specific surveys in Eswatini, we developed a compartmental model of heterosexual HIV transmission which included eight subpopulations and four sexual partnership types. We calibrated the model to stratified HIV prevalence, incidence, and ART cascade data. Taking observed cascade scale-up in Eswatini as the basecase — reaching 95-95-95 in the overall population by 2020 — we defined four counterfactual scenarios in which the population overall reached 80-80-90 by 2020, but where FSW, clients, both, or neither were disproportionately left behind, reaching only 60-40-80. We quantified relative additional cumulative HIV infections by 2030 in counterfactualvsbase-case scenarios. We further estimated linear effects of viral suppression gap among FSW and clients on additional infections by 2030, plus effect modification by FSW/client population sizes, rates of turnover, and HIV prevalence ratios.ResultsCompared with the base-case scenario, leaving behind neither FSW nor their clients led to the fewest additional infections by 2030: median (95% credible interval) 14.9 (10.4, 18.4) %vs26.3 (19.7, 33.0) % if both were left behind — a 73 (40, 149) % increase. The effect of lower cascade on additional infections was larger for clientsvsFSW, and both effects increased with population size and relative HIV incidence.ConclusionsInequalities in the ART cascade across subpopulations can undermine the anticipated prevention impacts of cascade scale-up. As Eswatini has shown, addressing inequalities in the ART cascade, particularly those that intersect with high transmission risk, could maximize incidence reductions from cascade scale-up.
Innovative Approaches in Pericardiocentesis Training: A Comparative Study of 3D-Printed Mannequins and Virtual Reality Simulations
Authors: Rubio-López Alberto , García-Carmona Rodrigo , Zarandieta-Román Laura , Rubio-Navas Alejandro , González-Pinto Ángel , Cardinal-Fernández Pablo 
Published: February 2024

AbstractBackgroundThe CoBaTrICE initiative standardized intensive care training throughout Europe. Pericardiocentesis, an important yet infrequent operation, poses unique training challenges often unmet by conventional methods. This study evaluates the efficacy of virtual reality (VR) simulations and 3D-printed mannequins in this procedure training, both crafted from scratch using highly affordable materials and free software.MethodsThirty-five final-year medical students participated in this prospective, quasi-experimental study. Initially, students underwent VR simulation training, followed by training using 3D-printed self-made mannequins. Learning outcomes were assessed using the Objective and Structured Clinical Examination (OSCE) questionnaire. Heart rate variability (HRV) analysis was employed to monitor stress responses, while the NASA Task Load Index (NASA-TLX) was used to gauge self-perceived difficulty.ResultsAlthough the mannequin model induced more stress reactions, it excelled in tasks requiring fine motor skills, such as correct placement and asepsis maintenance. In contrast, lower NASA-TLX scores indicated that the VR model imposed less mental demand and effort, reflecting a reduced cognitive load.ConclusionBoth VR simulations and 3D-printed mannequins effectively taught pericardiocentesis skills, each offering distinct advantages. Mannequins enhanced fine motor skills, whereas VR reduced cognitive load and increased engagement. The combination of both approaches could maximize training outcomes, particularly in resource-constrained environments, thus broadening access to advanced simulation education.
Similar and different: systematic investigation of proteogenomic variation between sexes and its relevance for human diseases
Authors: Koprulu Mine , Wheeler Eleanor , Kerrison Nicola D. , Denaxas Spiros , Carrasco-Zanini Julia , Orkin Chloe M. , Hemingway Harry , Wareham Nicolas J. , Pietzner Maik , Langenberg Claudia 
Published: February 2024

AbstractTo better understand sex differences in human health and disease, we conducted a systematic, large-scale investigation of sex differences in the genetic regulation of the plasma proteome (>5,000 targets), including their disease relevance.Plasma levels of two-thirds of protein targets differed significantly by sex. In contrast, genetic effects on protein targets were remarkably similar, with very few protein quantitative loci (pQTLs, n=74) showing significant sex-differential effects (for 3.9% and 0.3% of protein targets from antibody- and aptamer-based platforms, respectively). Most of these 74 pQTLs represented directionally concordant effects significant in both sexes, with only 21 pQTLs showing evidence of sexual dimorphism, i.e. effects restricted to one sex (n=20) or with opposite directions between sexes (n=1 for CDH15). None of the sex-differential pQTLs translated into sex-differential disease risk.Our results demonstrate strong similarity in the genetic regulation of the plasma proteome between sexes with important implications for genetically guided drug target discovery and validation.
Neuroradiological findings in GAA-FGF14ataxia (SCA27B): more than cerebellar atrophy
Authors: Chen Shihan , Ashton Catherine , Sakalla Rawan , Clement Guillemette , Planel Sophie , Bonnet Céline , Lamont Phillipa , Kulanthaivelu Karthik , Nalini Atchayaram , Houlden Henry , Duquette Antoine , Dicaire Marie-Josée , Iruzubieta Agudo Pablo , Ruiz Martinez Javier , Marco de Lucas Enrique , Sutil Berjon Rodrigo , Infante Ceberio Jon , Indelicato Elisabetta , Boesch Sylvia , Synofzik Matthis , Bender Benjamin , Danzi Matt C. , Zuchner Stephan , Pellerin David , Brais Bernard , Renaud Mathilde , La Piana Roberta 
Published: February 2024

AbstractBackgroundGAA-FGF14ataxia (SCA27B) is a recently reported late-onset ataxia caused by a GAA repeat expansion in intron 1 of theFGF14gene. Initial studies revealed cerebellar atrophy in 74-97% of patients. A more detailed brain imaging characterization of GAA-FGF14ataxia is now needed to provide supportive diagnostic features and earlier disease recognition.MethodsWe performed a retrospective review of the brain MRIs of 35 patients (median age at MRI 63 years; range 28-88 years) from Quebec (n=27), Nancy (n=3), Perth (n=3) and Bengaluru (n=2) to assess the presence of atrophy in vermis, cerebellar hemispheres, brainstem, cerebral hemispheres, and corpus callosum, as well as white matter involvement. Following the identification of the superior cerebellar peduncles (SCPs) involvement, we verified its presence in 54 GAA-FGF14ataxia patients from four independent cohorts (Tübingen n=29; Donostia n=12; Innsbruck n=7; Cantabria n=6). To assess lobular atrophy, we performed quantitative cerebellar segmentation in 5 affected subjects with available 3D T1-weighted images and matched controls.ResultsCerebellar atrophy was documented in 33 subjects (94.3%). We observed SCP involvement in 22 subjects (62.8%) and confirmed this finding in 30/54 (55.6%) subjects from the validation cohorts. Cerebellar segmentation showed reduced mean volumes of lobules X and IV in the 5 affected individuals.ConclusionsCerebellar atrophy is a key feature of GAA-FGF14ataxia. The frequent SCP involvement observed in different cohorts may facilitate the diagnosis. The predominant involvement of lobule X correlates with the frequently observed downbeat nystagmus.