bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers
Authors: Thompson Janice M. , Watts Stephanie W. , Terrian Leah , Contreras G. Andres , Rockwell Cheryl , Rendon C. Javier , Wabel Emma , Lockwood Lizabeth , Bhattacharya Sudin , Nault Rance 
Published: October 2023

SUMMARYPerivascular adipose tissue (PVAT) is increasingly recognized for its function in mechanotransduction. To examine the cell-specificity of recognized mechanotransducers we used single nuclei RNA sequencing (snRNAseq) of the thoracic aorta PVAT (taPVAT) from male Dahl SS rats compared to subscapular brown adipose tissue (BAT). Approximately 30,000 nuclei from taPVAT and BAT each were characterized by snRNAseq, identifying 8 major cell types expected and one unexpected (nuclei with oligodendrocyte marker genes). Cell-specific differential gene expression analysis between taPVAT and BAT identified up to 511 genes (adipocytes) with many (≥20%) being unique to individual cell types.Piezo1was the most highly, widely expressed mechanotransducer. Presence of PIEZO1 in the PVAT was confirmed by RNAscope® and IHC; antagonism of PIEZO1 impaired the PVAT’s ability to hold tension. Collectively, the cell compositions of taPVAT and BAT are highly similar, and PIEZO1 is likely a mechanotransducer in taPVAT.
Review of multilevel inverter for high-power applications
Authors: Barnawi Abdulwasa B. , Alfifi Abdull Rahman A. , Elbarbary Z.M.S. , Alqahtani Saad Fahed , Shaik Irshad Mohammad 
Published: October 2023

PurposeTraditional level inverter technology has drawbacks in the aspect of Total harmonic distortion (THD) and switching losses for higher frequencies. Due to these drawbacks, two-level inverters have become unprofitable for high-power applications. Multilevel inverters (MLIs) are used to enhance the output waveform characteristics (i.e. low THD) and to offer various inverter topologies and switching methods.Design/methodology/approachMLIs are upgraded versions of two-level inverters that offer more output levels in current and voltage waveforms while lowering the dv/dt and di/dt ratios. This paper aims to review and compare the different topologies of MLI used in high-power applications. Single and multisource MLI's working principal and switching states for each topology are demonstrated and compared. A Simulink model system integrated using detailed circuit simulations in developed in MATLAB®–Simulink program. In this system, a constant voltage source connected to MLI to feed asynchronous motor with squirrel cage rotor type is used to demonstrate the efficacy of the MLI under different varying speed and torque conditions.FindingsMLI has presented better control and good range of system parameters than two-level inverter. It is suggested that the MLIs like cascade-five-level and NPC-five-level have shown low current harmonics of around 0.43% and 1.87%, respectively, compared to two-level inverter showing 5.82%.Originality/value This study is the first of its kind comparing the different topologies of single and multisource MLIs. This study suggests that the MLIs are more suitable for high-power applications.
Does financial market development really drive migrant remittances’ flow in Sub-Saharan Africa?
Authors: Ikpesu Olapeju 
Published: October 2023

PurposeThe discussion on international migration has become a significant part of globalization and a topical issue in international relations, especially in developing economies which mostly relies on migrant remittances. The purpose of the study is to examine whether financial market development (equity market development and banking sector development) really drives migrant remittance flow in Sub-Saharan Africa (SSA).Design/methodology/approachThe study employs the dynamic heterogeneous panel data approach-the pool mean group (PMG) and the mean group (MG) techniques in analyzing the model based on data obtained from 27 SSA countries covering the period 2000–2020.FindingsThe findings of the study revealed that financial market development (equity market development and banking sector development) is a key driver of migrant remittances flows in the SSA region. In addition, the study revealed that the following macroeconomic variables such as real interest rate, unemployment rate, global growth, emigration, and economic growth are also determinants of migrant remittances flows in the SSA region.Originality/valueThe reviewed empirical literature revealed that several studies documents that the macroeconomic determinants of migrant remittances include inflation, GDP, interest rate, exchange rate, population growth, financial sector development and unemployment rate. Most of these studies fail to capture both equity market development and robust banking sector development (financial market development) as critical drivers of migrant remittances flow in SSA. Also, this study uses a robust measure of equity market development and banking sector development, unlike previous studies.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-05-2023-0361
The role of attributes defining intervention concepts in international doctrinal documents on built heritage
Authors: Lin Mi , Nevzgodin Ivan , Pereira Roders Ana , de Jonge Wessel 
Published: October 2023

PurposeAttributes conveying cultural significance play a key role in heritage management, as well as in differentiating interventions in built heritage. However, seldom the relation between interventions and attributes, either tangible or intangible, has been researched systematically. How do both tangible and intangible attributes and interventions relate? What attributes make interventions on built heritage differ?Design/methodology/approachThis paper conducts a systematic content analysis of forty-one international doctrinal documents—mainly adopted by the Council of Europe, UNESCO and ICOMOS, between 1877 and 2021. The main aim is to reveal and compare the selected eight intervention concepts, namely—restoration (C1), preservation (C2), conservation (C3), adaptation (C4), rehabilitation (C5), relocation (C6), reconstruction (C7) and renewal (C8)—and their definitions, in relation to attributes, both tangible and intangible. The intensity of the relationship between intervention concepts and attributes is determined based on the frequency of the mentioned attributes per intervention.FindingsThere were three key findings. First, although the attention to intangible attributes has increased in the last decades, the relationship between interventions and tangible attributes remains stronger. The highest frequency of referencing the tangible attributes was identified in “relocation” and “preservation,” while the lowest was in “rehabilitation.” Second, certain attributes play contradictory roles, e.g. “material,” “use” and “process,” which creates inconsistent definitions between documents. Third, as attributes often include one another in building layers, they trigger the intervention concepts in hierarchical patterns.Originality/valueThis paper explores and discusses the results of a novel comparative analysis between different intervention concepts and definitions, with a particular focus on the attributes. The results can support further research and practice, clarifying the identified differences and similarities.
From family firm to Japanese OEM in tacit knowledge innovation: a case study of Sin Kwang plastic resources in Malaysia
Authors: Kean Yew Lee 
Published: October 2023

PurposeAlthough it is a well-known notion that “a family firm does not survive beyond the third generation”, owing to the ineffective tacit knowledge transfer, studies investigating the relationship between generational evolution and knowledge innovation is scarce. Thus, this case study revolving Sin Kwang Plastic Resources Berhad (SKP) seeks to address this gap in literature.Design/methodology/approachTo assess the development of family business, a longitudinal case study was performed by documenting the entire evolutionary process starting from its establishment until now. The historical profiles for SKP were obtained from the previous annual reports submitted to the government's Companies Commission (SSM). Secondary materials from the Federation of Malaysian Manufacturers (FMM) and the edge newspaper and articles on the company were also gathered. Throughout the in-depth interviews, the author can see how the next generation of this family firm innovates and implements tacit knowledge innovation in original equipment manufacturing (OEM) by adhering to the Japanese industrial standards.FindingsFindings show that the second generation utilized the company's extensive knowledge in plastic contract manufacturing in SKP for tacit knowledge conversion, triggers the birth of STS Tecnic Berhad, a subsidiary company that manufactures plastic parts for the industrial packaging and automotive industry. To simplify the process of managing the complex business, SKP opted to “prune the family tree” by dividing the business, involving fewer managers and restricting the number of family shareholders.Practical implicationsThis case study traces how Gan's family's tacit knowledge in plastic contract manufacturing have been acquired from the experience of contract manufacturing with the Japanese multinational corporations (MNCs) by further commercializing the tacit knowledge into different companies for different plants. SKP promotes tacit knowledge innovation in the learning organization, thus responding to the firm's sustainability.Originality/valueThis study demonstrates that knowledge transformation plays vital roles in product development and gaining competitive advantage. The success of this business is founded by the building of shared values, norms and technical understanding in plastic contract manufacturing among the Japanese MNCs in Malaysia.
Optimal industrial structure and economic growth: a new measurement method and application
Authors: Huang Yunjue , Ye Dezhu , Xu Shulin 
Published: October 2023

PurposeThe purpose of this paper is to explore the matching relationship between factor endowment and industrial structure, and its impact on economic growth.Design/methodology/approachThe assortative matching method is developed to quantitatively measure the matching between factor endowment and industrial structure. A series of empirical tests are then carried out to evaluate the impact on the economic development of the matching.Findings1) The matching between factor endowment and industrial structure has a significantly positive impact on economic growth. (2) Economic growth reaches its maximum when the gap between the two sectors narrows to zero. (3) This effect is particularly significant for countries with higher GDP per capita and GNI per capita. (4) The results remain robust after employing a series of tests.Practical implicationsAggressive industrial policies are not desirable. The optimal industrial structure is the one that complied with the comparative advantage of the given factor endowment in the economy.Originality/valueSo far, there has been a significant lack of an applicable quantitative indicator for measuring the matching between factor endowment and industrial structure, which is essential for conducting empirical tests and providing evidence for related economic theories.
Long‐term predictors of morbidity and mortality in patients following LVAD replacement
Authors: Jimenez Contreras Fabian , Rames Jess David , Schroder Jacob , Russell Stuart D. , Katz Jason , Omer Tariq , Barac Yaron D. , Milano Carmelo 
Published: October 2023

AbstractBackgroundAs heart transplant guidelines evolve, the clinical indication for 73% of durable left ventricular assist device (LVAD) implants is now destination therapy. Although completely magnetically levitated LVAD devices have demonstrated improved durability relative to previous models, LVAD replacement procedures are still required for a variety of indications. Thus, the population of patients with a replaced LVAD is growing. There is a paucity of data regarding the outcomes and risk factors for those patients receiving first‐time LVAD replacements.MethodsThe study cohort consisted of all consecutive patients between 2006 and 2020 that received a first‐time LVAD replacement at a single institution. Preoperative clinical and laboratory variables were collected retrospectively. The primary endpoint was death or need for an additional LVAD replacement. Data were subjected to Kaplan–Meier, univariate, and multivariate Cox hazard ratio analyses.ResultsIn total, 152 patients were included in the study, of which 101 experienced the primary endpoint. On multivariate analysis, patients receiving HeartMate 3 (HM3) LVADs as the replacement device showed superior outcomes (HR 0.15, 95% CI 0.065–0.35, p < 0.0001). Independent risk factors for death or need for additional replacement included preoperative extracorporeal membrane oxygenation (ECMO) (HR 4.44, 95% CI 1.87–14.45, and p = 0.00042), increased number of sternotomies (HR 5.20, 95% CI 1.87–14.45, and p = 0.0016), and preoperative mechanical ventilation (HR 1.98, 95% CI 1.01–3.86, and p = 0.045).ConclusionsReplacement with HM3 showed superior outcomes compared to all other pump types when controlling for both initial pump type and other independent predictors of death or LVAD replacement. Preoperative ECMO, mechanical ventilation, and multiple sternotomies also increased the odds for death or the need for subsequent replacement.
From the margins to the center: Advancing research on caregiver socialization of emotion in Asia
Authors: Raval Vaishali V. 
Published: October 2023

AbstractAs in other fields of developmental science, emotion socialization research in Asia, where nearly 60% of the world's population lives, has emerged on the margins. Contextualizing this marginalization within colonial foundations of our science, in this article, I discuss the historic dominance of the Global North frameworks of emotion socialization. I also address associated limitations of emotion socialization research in Asia, recent conceptualizations that integrate cultural processes and emerging insights from this research, and the need for a decolonial framework to further advance this literature. A decolonial framework would enable scholars to contextualize emotion socialization within local milieus; use research methods valued by local communities; and interpret emotion‐related beliefs and behaviors in Asia as assets, not deficits. Adopting a decolonial framework can move emotion socialization research in Asia from the margins to the center of emotion socialization literature, generating knowledge to support the well‐being of children in Asia and around the world.
Effect of in ovo feeding of folic acid on Disabled‐1 and gga‐miR‐182‐5p expression in the cerebral cortex of chick embryo
Authors: Heydari Behnaz , Mashayekhi Farhad , Kashani Maryam Haji Ghasem 
Published: October 2023

AbstractFolate (vitamin B9) has been shown to reduce the prevalence of neural tube defects (NTDs). Many genes comprising Disabled‐1 (DAB1) and miRNAs have been shown to play important role in normal brain development. Reelin‐signalling has been shown to play key role in regulating of neuronal migration during brain development. The aim of this study was to evaluate the effects of in ovo administration of folic acid (FA) on DAB1 and gga‐miR‐182‐5p expression in the cerebral cortex of chick embryo. A total number of 30 hatching eggs were used in this study. The number of 10 eggs were injected into the yolk sac with FA (150 µg/egg), 10 eggs by normal saline (sham group) on embryonic day 11 and 10 eggs were left without injection as control. Then the cerebral cortices were collected on E19 and the expression of DAB1 and gga‐miR‐182‐5p was studied by Real‐Time PCR. The results showed that DAB1 expression in the cerebral cortex of FA‐treated, sham and control were 2.51 ± 0.13, 1.01 ± 0.04 and 1.03 ± 0.04 fold changes, respectively, and this amount for gga‐miR‐182‐5p were 0.54 ± 0.03, 1.09 ± 0.07 and 1.00 ± 0.06‐fold change respectively. Statistical analysis showed that there is a significant increase in DAB1 and a decrease in gga‐miR‐182‐5p expression in FA injected cerebral cortex as compared either with either SHAM or control (p < 0.0001). But, no significant change in DAB1 and gga‐miR‐182‐5p expression was observed between sham and the control group (p = 0.99 and p = 0.57 respectively). It is concluded that in ovo feeding of FA increases DAB1 and decreases gga‐miR‐182‐5p expression in the developing chick cerebral cortex.
In search of public values in performance budgeting studies
Authors: Ho Alfred Tat‐Kei , Shen Chen , Xu Yan 
Published: October 2023

AbstractPerformance budgeting is inevitably linked to policy priorities, and priorities are fundamentally the expression of public values. Through a bibliometric analysis of past studies, this study shows that over time, the performance budgeting literature is linked to more diverse values beyond efficiency and effectiveness concerns. Transparency, democracy, participation, inclusiveness, and other political, legal, social, and sustainability values have been getting more attention in public administration, accounting, and budgeting journals, as well as in various field journals. This study concludes by suggesting a need for more interdisciplinary and comparative research about the normative foundation of performance budgeting and its connection with public value theory in the future.
Reduced Order Synchronization of Two Non-Identical Special Class of Strict Feedback Systems Via Back-Stepping Control Technique
Authors: Bora Riddhi Mohan , Sharma Bharat Bhushan 
Published: October 2023

AbstractThis work offers a systematic technique to achieve reduced order synchronization (ROS) between two different order general classes of chaotic systems in a master-slave configuration. In this study, the dynamics of the master and slave systems are assumed to follow a special class of strict-feedback form, namely, the generalized triangular feedback form. The main objective is to design a suitable scalar controller using a Lyapunov theory-based back-stepping approach such that the mth order slave system gets synchronized with the nth order master system. Due to the difference in the order of the systems (m&lt;n and m=(n−1)), it is only possible to achieve the synchronization between m numbers of states of the slave systems with (n−1) numbers of states of the master system, respectively. We cannot conclude on the stability of the nth state of the master system as there is no counterpart (state) available in the slave system to be synchronized with. Adding an additional (m+1)th state dynamics along with a nonlinear feedback controller (U1) to the slave system ensures that the nth state of the master system is synchronized with the (m+1)th state dynamics of the slave system. With the suggested technique proposed in this article, complete state-to-state synchronization can be achieved with only two controllers. The analytical results are successfully validated through numerical simulations presented in the end.
Systematic Review of Accelerometer Responsiveness to Change for Measuring Physical Activity, Sedentary Behavior, or Sleep
Authors: Clevenger Kimberly A. , Montoye Alexander H.K. 
Published: October 2023

Measurement of 24-hr movement behaviors is important for assessing adherence to guidelines, participation trends over time, group differences, and whether health-promoting interventions are successful. For a measurement tool to be useful, it must be valid, reliable, and able to detect change, the latter being a measurement property called responsiveness, sensitivity to change, or longitudinal validity. We systematically reviewed literature on the responsiveness of accelerometers to detect change in 24-hr movement behaviors. Databases (PubMed, Scopus, and EBSCOHost) were searched for peer-reviewed papers published in English between 1998 and 2023. Quality/risk of bias was assessed using a customized tool. This study is registered at https://osf.io/qrn8a. Twenty-six papers met the inclusion/exclusion criteria with an overall sample of 1,939 participants. Narrative synthesis was used. Most studies focused on adults (n = 21), and almost half (n = 12) included individuals with specific medical conditions. Studies primarily took place in free-living settings (n = 21) and used research-grade accelerometers (n = 24) worn on the hip (n = 18), thigh (n = 7), or wrist (n = 9). Outcomes included physical activity (n = 19), sedentary time/behavior (n = 12), or sleep (n = 2) and were calculated using proprietary formulas (e.g., Fitbit algorithm), cut points, and/or count-based methods. Most studies calculated responsiveness by comparing before versus after an intervention (n = 16). Six studies included a criterion measure to confirm that changes occurred. Limited research is available on the responsiveness of accelerometers for detecting change in 24-hr movement behaviors, particularly in youth populations, for sleep outcomes, and for commercial and thigh- or wrist-worn devices. Lack of a criterion measure precludes conclusions about the responsiveness even in more frequently studied outcomes/populations.
Optimization of IspS
ib
stability through directed evolution to improve isoprene production
Authors: Li Meijie , Yang Rumeng , Guo Jing , Liu Min , Yang Jianming 
Published: October 2023

ABSTRACT

Enzyme stability is often a limiting factor in the microbial production of high-value-added chemicals and commercial enzymes. A previous study by our research group revealed that the unstable isoprene synthase from
Ipomoea batatas
(IspS
ib
) critically limits isoprene production in engineered
Escherichia coli
. Directed evolution was, therefore, performed in the present study to improve the thermostability of IspS
ib
. First, a tripartite protein folding system designated as lac′-IspS
ib
-′lac, which could couple the stability of IspS
ib
to antibiotic ampicillin resistance, was successfully constructed for the high-throughput screening of variants. Directed evolution of IspS
ib
was then performed through two rounds of random mutation and site-saturation mutation, which produced three variants with higher stability: IspS
ib
N397V A476V
, IspS
ib
N397V A476T
, and IspS
ib
N397V A476C
. The subsequent
in vitro
thermostability test confirmed the increased protein stability. The melting temperatures of the screened variants IspS
ib
N397V A476V
, IspS
ib
N397V A476T
, and IspS
ib
N397V A476C
were 45.1 ± 0.9°C, 46.1 ± 0.7°C, and 47.2 ± 0.3°C, respectively, each of which was higher than the melting temperature of wild-type IspS
ib
(41.5 ± 0.4°C). The production of isoprene at the shake-flask fermentation level was increased by 1.94-folds, to 1,335 mg/L, when using IspS
ib
N397V A476T
. These findings provide insights into the optimization of the thermostability of terpene synthases, which are key enzymes for isoprenoid production in engineered microorganisms. In addition, the present study would serve as a successful example of improving enzyme stability without requiring detailed structural information or catalytic reaction mechanisms.

IMPORTANCE

The poor thermostability of IspS
ib
critically limits isoprene production in engineered
Escherichia coli
. A tripartite protein folding system designated as lac'-IspS
ib
-'lac, which could couple the stability of IspS
ib
to antibiotic ampicillin resistance, was successfully constructed for the first time. In order to improve the enzyme stability of IspS
ib
, the directed evolution of IspS
ib
was performed through error-PCR, and high-throughput screening was realized using the lac'-IspS
ib
-'lac system. Three positive variants with increased thermostability were obtained. The thermostability test and the melting temperature analysis confirmed the increased stability of the enzyme. The production of isoprene was increased by 1.94-folds, to 1,335 mg/L, using IspS
ib
N397V A476T
. The directed evolution process reported here is also applicable to other terpene synthases key to isoprenoid production.