bluuebunny/crossref_metadata_2025_split huggingface dataset:
The black swan: a case of central nervous system graft-versus-host disease
Authors: Butera Sara , Tavarozzi Rita , Brunello Lucia , Rivela Paolo , Sofia Antonella , Viero Lorenzo , Salvio Michela , Ladetto Marco , Zallio Francesco 
Published: October 2023

Abstract

Objectives
Graft-versus-host disease (GVHD) of central nervous system is an atypical and rare manifestation of chronic GVHD, presenting with a heterogeneous spectrum of signs and symptoms. Diagnosis of neurological manifestations of GVHD can be highly challenging and remain associated with dismal prognosis, significant morbidity, and reduced quality of life.

Case presentation
In this report, we describe a 39-year-old woman developing neurological signs and symptoms 8 months after allogeneic HSCT magnetic resonance imaging showed multifocal hyperintense lesions involving the periventricular region and frontal subcortical white matter. There was no laboratory evidence of infective or malignant etiology, and the case was diagnosed as CNS-GVHD. The patient was treated with intravenous methylprednisolone pulse therapy and the clinical conditions gradually improved. After few months, patient symptoms progressed despite the addition of high-dose intravenous immunoglobulin, tacrolimus, and a new course of high dose steroids. To engage targeted therapy, the patient underwent brain biopsy that revealed a loss of myelin fibers, perivascular and diffuse infiltration of T cells, and macrophages associated with reactive gliosis, representing a demyelinating disease. We intensified treatment with cyclophosphamide and subsequently introduced ibrutinib as salvage strategy. Despite a magnetic resonance imaging showing great regression of the demyelinating lesions, patient’s conditions deteriorated and she died 16 months after HSCT.

Conclusions
CNS-GVHD is a rare complication of HSCT that is difficult to diagnose. Based on our experience, brain biopsy may represent a useful diagnostic tool when the clinical features of neurological symptoms are ambiguous or in patients without evidence of preceding chronic GVHD.
WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
Authors: Yuan Xuesong , Bao Qing , Lu Bin , Xiang Chong , Hou Xiaoshan , Wei Wenfeng 
Published: October 2023

Abstract
Intracranial aneurysm (IA) is a type of cerebrovascular disease that mainly occurs in the circle of Willis. Abnormalities in RNA methylation at the N6-methyladenosine (m6A) site have been associated with numerous types of human diseases. WTAP recruits the m6A methyltransferase complexes to the mRNA targets, and its expression is positively correlated with m6A methylation levels. This research aimed to explore the potential mechanisms of m6A methylation in IA. A selective arterial ligation method was used to establish an IA rat model; thereafter, the m6A methylation level and m6A methylation-related genes were determined in blood and circle of Willis samples using a commercial kit and real-time quantitative PCR, respectively. Subsequently, rat brain microvascular endothelial cells (rBMVECs) were treated with TNF-α, and the expression of m6A methylation-related genes within the cells were assessed. Lastly, the effects of WTAP on TNF-α-induced rBMVECs were further investigated through in vitro experiments. In result, the m6A RNA methylation level evidently declined in the blood and circle of Willis’ samples of the IA rats, as compared to the corresponding samples from the control rats (P < 0.05). Compared to the results in the control rats/cells, WTAP expression was significantly downregulated, whereas ALKBH1 expression was evidently upregulated in the blood and circle of Willis samples of the TNF-α-induced rBMVECs of IA rats. Consequently, TNF-α-induced rBMVECs and rBMVECs with WTAP overexpression were successfully established. TNF-α inhibited the viability of the rBMVECs, promoted apoptosis, and significantly upregulated cleaved-caspase3 and downregulated WTAP expression. In contrast, WTAP overexpression significantly reversed these changes caused by TNF-α (P < 0.05). In conclusion, WTAP overexpression may modulate the growth of TNF-α-induced rBMVECs by enhancing WTAP expression and its m6A methylation.
Preparation and properties of ABS/BNNS composites with high thermal conductivity for FDM
Authors: Chen Caifeng , Zhong Wuwen , Guo Junhao , Liu Kai , Wang Andong 
Published: October 2023

Abstract
Acrylonitrile-butadiene-styrene (ABS) resin is a widely used engineering plastic at present. Due to its excellent mechanical properties and high fluidity, it is utilized in fused deposition molding (FDM) technology. In this paper, boron nitride nanosheets (BNNS) were prepared by hydrothermal exfoliation and used as nano-fillers for ABS resin, and ABS/BNNS composite wires for FDM printing were prepared by melt blending method. The results showed that BNNS with fewer layers were obtained; the addition of BNNS to the ABS resin matrix could effectively enhance the thermal conductivity of the composites. When the addition amount of BNNS was 15 wt%, the thermal conductivity of the composite increased to 0.369 W/(m K), which was 120.06 % higher than that of pure ABS (0.174 W/(m K)). In addition, BNNS also improves the mechanical properties, thermal stability, and melt flow rate of the composites, thus making ABS composite wires more suitable for FDM printing.
Hungary in the European Union – Cooperation, Peacock Dance and Autocracy
Authors: Éltető Andrea , Szemlér Tamás 
Published: October 2023

Abstract
Hungary had been one of the frontrunners in the political and economic transition process in Central and Eastern Europe in the 1990s, and in 2004 it joined the European Union. Since 2010, Hungary has gradually become an autocratic regime, a process that has been facilitated by the political benefits of EU integration and money transfers. While the support of the Hungarian people for EU membership has remained high, tensions have increased between the Hungarian government and EU institutions. This article evaluates how the external shock of Russia’s war against Ukraine has shaken Hungary’s so far developed authoritarian equilibrium within the EU. The authors show how embedded the Hungarian autocracy has become and argue that although there have been some effects to the pillars of the authoritarian equilibrium, it has remained stable, and most probably will continue to do so, as long as the illiberal regime stays in power.
CST3 alleviates bilirubin-induced neurocytes’ damage by promoting autophagy
Authors: Li Zhenkun , Du Yating 
Published: October 2023

Abstract
High concentrations of unconjugated bilirubin (UCB) have toxic effects. The aim of our study was to find a way to elevate UCB tolerance or inhibit its toxicity in neurocytes. It has been reported that cystatin C (CST3) concentrations have a significant positive correlation with total bilirubin (TB) levels and a negative correlation with albumin levels. In addition, CST3 can directly bind UCB, decrease human umbilical vein endothelial cells’ permeability, improve blood–brain barrier integrity after ischemic brain injury in mice, and induce autophagy. We hypothesized that CST3 could increase the solubility of UCB, decrease permeability of neurocytes, induce autophagy of neurocytes, and alleviate bilirubin-induced damage. To verify our hypothesis, we measured TB and conjugated bilirubin levels, and the permeability and autophagy of neurocytes treated with UCB and CST3. Our findings suggest that CST3 can protect against UCB-induced damage in neurocytes and that autophagy played an important role in this process.
Preparing Graduates for the Workforce: The Development of Contextual-Based History Learning E-Modules in Vocational Schools
Authors: Marta Nur Aeni , Abdurakhman Abdurakhman , Djunaidi Djunaidi 
Published: October 2023

During the COVID-19 pandemic, history lessons were carried out online. As a result, several obstacles are encountered, including internet network problems. Teachers have difficulty carrying out learning activities in class optimally and meaningfully. Meanwhile, there has been no contextual-based history e-module for Vocational High Schools. Even though history learning for SMK should be different from SMA. The direction and objectives of SMK learning are to strengthen graduate competency standards to be ready for work. For this reason, researchers recommend using contextually based e-modules as an effort to prepare graduates who are ready to work. Contextual e-modules are modules that are presented electronically; the material is related to other subject matter that is relevant to the field of vocational science and graduate competency achievements. The research used the RD method with the ADDIE approach. The results of the study show that contextually based E-modules can optimize history learning and encourage innovative creativity. The advantages of contextually based E-modules are that the material is related to areas of expertise, easily accessible at any time, and can be studied independently and repeatedly. As a result, learning history can be carried out effectively and thoroughly.Pada masa pandemi COVID-19, pembelajaran sejarah dilakukan secara daring. Dampaknya, terdapat beberapa kendala yang dihadapi di antaranya adalah masalah jaringan internet. Guru mengalami kesulitan melaksanakan kegiatan pembelajaran di kelas secara optimal dan bermakna. Sementara itu, selama ini belum ada e-modul sejarah berbasis kontekstual untuk SMK. Padahal seharusnya pembelajaran sejarah untuk SMK berbeda dengan SMA. Arah dan tujuan pembelajaran SMK adalah memperkuat standar kompetensi lulusan untuk siap kerja. Untuk itu, peneliti merekomendasikan penggunaan e-modul berbasis kontekstual sebagai upaya mempersiapkan lulusan yang siap kerja. E-modul berbasis kontekstual merupakan modul yang disajikan melalui elektronik, materi dikaitkan dengan materi pelajaran lain yang relevan dengan bidang ilmu kejuruan dan capaian kompetensi lulusan. Penelitian menggunakan metode RD dengan pendekatan ADDIE. Hasil penelitian menunjukkan E-modul berbasis kontekstual dapat mengoptimalkan pembelajaran sejarah dan mendorong muncul kretivitas inovasi baru. Kelebihan E-modul berbasis kontekstual adalah materi dikaitkan dengan bidang keahlian, mudah diakses kapan saja, serta dapat dipelajari secara mandiri, dan berulang-ulang. Dampaknya, pembelajaran sejarah dapat dilakukan secara efektif dan tuntas.
Toponymy of Bandung City in Mancapat Perspective (Quarter Typology)
Authors: Yulifar Leli , Aman Aman , Risagarniwa Yuyu Yohana 
Published: October 2023

Nowadays, the community and the government tend to rename a location without recognizing its historical significance when, in fact, the naming of a place reflects a national identity, and in some areas, it incorporates mitigating elements, including the city of Bandung. For this reason, this study was conducted to discover the origins of place names in the city of Bandung with historical and other meanings to ensure that they will be taken into account by all parties when naming or renaming places/areas in Bandung. That being the case, a historical method with a toponomatology approach (toponymy) and the concept of mancapat (quarter typology) were employed in this study, resulting in a toponymy for the city of Bandung based on a naming pattern that refers to the concept of traditional urban planning (mancapat/circular pattern) which is in line with its historical meanings, with a time frame between 1810-2000. This is distinct from the patterns or concepts researchers adopt, typically referring to natural or socio-cultural phenomena (linear patterns). Therefore, the findings of this study can offer new insights into tracing the origins of specific locations through historical analysis supported by the concept of traditional Javanese planology (mancapat) or quarter typology. Thus, toponymy researchers can adopt it for other traditional inland state cities in Indonesia. Saat ini terdapat kecenderungan masyarakat juga pemerintah mengganti nama sebuah tempat tanpa mempertimbangkan segi kesejarahannya. Padahal, penamaan tempat tersebut menunjukkan sebuah jati diri bangsa, bahkan untuk beberapa daerah mengandung unsur mitigasi, termasuk di dalamnya wilayah Kota Bandung. Oleh karena itu, kajian ini bertujuan untuk menemukan asal-usul nama tempat di Kota Bandung yang memiliki makna sejarah dan makna lainnya, agar menjadi pertimbangan para pihak saat akan mengganti atau memberi nama tempat/kawasan di Kota Bandung. Untuk itu, metode sejarah dengan pendekatan Toponomatology (Toponimi) dan konsep Mancapat (Typology Kuarter ) digunakan di dalam penelitian ini, sehingga dihasilkan Toponimi Kota Bandung berdasar pola penamaan yang mengacu kepada konsep tata kota tradisional (mancapat/pola sirkular) yang in line dengan makna kesejarahannya, dengan bingkai waktu antara 1810-2000. Hal ini berbeda dari pola atau konsep yang selama ini digunakan para peneliti yang pada umumnya mengacu kepada fenomena alam atau sosio kultural (pola linear). Dengan demikian, hasil penelitian ini dapat memberikan khazanah yang baru di dalam mengungkapkan asal-usul tempat, yakni analisis historis yang dibantu konsep planologi (tata kota) tradisional di Jawa (Mancapat) atau Typology Kuarter. Maka, para peneliti toponimi bisa mengadopsinya untuk kota-kota tradisional pedalaman (inland state) lainnya di Nusantara.
Cosmopolitan Palembang: Palembang's Interconnection and Global Trade in 1900-1930
Authors: Wargadalem Farida Ratu , Putra Diki Tri Apriansyah , Wasino Wasino 
Published: October 2023

The interconnection and global trade developing interrelated regional linkages is an important phenomenon for modern developments, interestingly emphasizing historical context. This aligns with the historical context of Palembang, a region with long-establishing international relations and is considered a cosmopolitan city with global-scale connections toward the 20th century. Therefore, this study aimed to evaluate Palembang's interconnection and global trade from 1900-1930, mainly emphasizing the exploration of worldwide networks and the transformation of the region as a cosmopolitan city. The analysis used a historical method with four stages: heuristics, verification, interpretation, and historiography. The results showed that Palembang experienced rapid progress after its export commodities, such as coffee, rubber, wood, tea, oil, coal, etc., were extensively traded in the world market. European investors and multinational companies, including Handelsvereeniging Amsterdam, Cultuurmaatschappij Indragiri, Straits Sunda Syndicate, etc., were also competing to open and expand their business in the city. This economic progress triggered the transformation of Palembang into a cosmopolitan city, promoting the impact of social change in the environment. Interkoneksi dan perdagangan global yang menimbulkan keterkaitan wilayah satu sama lain menjadi fenomena penting bagi perkembangan dunia saat ini. Tentu sangat menarik apabila interkoneksi dan perdagangan global dilihat dari konteks kesejarahan. Salah satu wilayah yang telah lama menjalin hubungan internasional adalah Palembang. Menjelang abad 20, Palembang hadir sebagai kota kosmopolitan dengan koneksi berskala global. Artikel ini membahas tentang interkoneksi dan perdagangan global Palembang tahun 1900-1930. Fokus utamanya adalah menelusuri jaringan perdagangan global serta transformasi Palembang sebagai kota kosmopolitan. Artikel ini bertujuan untuk menjelaskan jaringan perdagangan global dan transformasi kota kosmopolitan di Palembang. Metode yang digunakan adalah sejarah dengan empat tahapan: heuristik, verifikasi, interpretasi, dan historiografi. Hasil penelitian menunjukkan bahwa Palembang telah mengalami kemajuan pesat sejak komoditas ekspornya seperti kopi, karet, kayu, teh, minyak, batubara, dan lain-lain sangat laku di pasar dunia. Investor Eropa, dan perusahaan multinasional seperti Handelsvereeniging Amsterdam, Cultuurmaatschappij Indragiri, Straits Sunda Syndicate, dan lain-lain berlomba-lomba membuka, dan memperluas lahan bisnisnya di daerah ini. Kemajuan ekonomi ini memicu transformasi Palembang menjadi kota kosmopolitan. Serta membawa dampak perubahan sosial dalam masyarakat Palembang.
Genistein ameliorates starvation-induced porcine follicular granulosa cell apoptosis
Authors: Wu Guoyun , Song Dan , Wu Huadong , Zhao Fang , Ding Wei , Wang Zhe , Shi Fangxiong , Wei Quanwei 
Published: October 2023

In brief
Genistein contributes to granulosa cell (GC) survival by two routes: one is that genistein induced p-AMPK and inhibited p-mTOR, which induces LC3 activation and autophagy; the other is that genistein inhibited caspase-3 and its cleavage, which induces PARP1 activation and PARylation.

Abstract
Genistein is an isoflavone which is beneficial for health, but little is known regarding its function on granulosa cell fate during follicular atresia. In the present study, we established an in vitro model of porcine follicular granulosa cell apoptosis by serum deprivation and showed that treatments with 1 μM and 10 μM genistein significantly reduced the apoptotic rate of granulosa cells compared to the blank control (P < 0.05). These results suggest that genistein at micromolar levels alleviates serum deprivation-induced granulosa cell apoptosis, and the ameliorative effect of genistein on granulosa cell apoptosis is likely to be able to inhibit nutrient depletion-induced follicular atresia. Further experimental results revealed that the expression of the autophagic marker protein LC3II in 100 nM–10 μM genistein treatment increased in a dose-dependent manner and was higher than the control (P < 0.05). Genistein also dose dependently promoted the phosphorylation of AMPK (adenosine 5’-monophosphate-activated protein kinase) in granulosa cells. Poly(ADP-ribose) (pADPr) formation in genistein-treated groups was also notably higher than in the controls (P < 0.05). Collectively, genistein alleviates serum deprivation-induced granulosa cells in vitro through enhancing autophagy, which involving AMPK activation and PARylation signaling. However, further study should be carried out to investigate the role of the aforementioned signaling on this process.
Kompetensi Penyuluh Agama dalam Memberikan Bimbingan Pranikah pada Calon Pengantin di Kantor Urusan Agama Padang Barat
Authors: Lorensia Yola Friska , Afnibar Afnibar , Wahyuni Yeni Fitri , Hidayat Thaufiq , Asmawati Asmawati 
Published: October 2023

Abstract: Religious extensions provide premarital guidance so that prospective bridal couples get a lasting marriage. But in reality, currently there are many divorces that occur at the West Padang KUA. It is suspected that religious extension have not been professional in carrying out their duties, with low competence. The objectives of this study include: first, to determine the substantive competence related to the theoretical ability of religious extension at the KUA Padang Barat. Second, to determine the methodological competence of religious extension at the KUA Padang Barat. This research uses a descriptive qualitative method. The research data sources are religious extensions, and bridal couples who have attended premarital guidance. Taking data sources using purposive sampling technique. Data collection techniques using observation and interviews. The results showed that: 1) Substantive competence related to knowledge and skills has theoretically run optimally, it's just that a small part of the extensions needs to improve his competence; and 2) Methodological competence of religious extensions, related to applicative knowledge, applicative skills and attitudes as a whole, the extension is good enough, this is indicated by the extension not only explaining the material one way, but also providing opportunities for prospective brides to ask questions and respond to the material, so that prospective brides can understand the material well.Abtsrak: Penyuluh Agama memberikan bimbingan pranikah bertujuan agar calon pasangan pengantin mendapatkan pernikahan yang langgeng. Namun kenyataannya, saat ini banyak perceraian yang terjadi di KUA Padang Barat. Hal ini diduga Penyuluh Agama belum profesional dalam menjalankan tugasnya, dengan kompetensi yang rendah. Tujuan penelitian ini untuk mengetahui kompetensi substantif dan kompentensi metodologis Penyuluh Agama di KUA Padang Barat. Penelitian ini menggunakan metode kualitatif yang bersifat deskriptif. Sumber data penelitian ialah Penyuluh Agama, dan pasangan pengantin yang sudah mengikuti bimbingan pranikah. Teknik pengumpulan data menggunakan observasi dan wawancara. Hasil penelitian menunjukkan, bahwa: kompetensi Penyuluh Agama di Kantor Urusan Agama Padang Barat mencakup pemahaman teoritis yang kuat, keterampilan komunikasi yang efektif, pemahaman terhadap nilai-nilai agama, sensitivitas terhadap masalah psikologis, dan kemampuan memberikan panduan praktis terkait pernikahan. Meskipun sebagian besar dari mereka telah berhasil mencapai tingkat kompetensi yang baik, masih ada potensi untuk peningkatan.
MULTICRITERION OPTIMIZATION OF PRESS COLUMN CROSSSECTION
Authors: Shevchenko V. , Ryagin S. , Artsybasheva D. 
Published: October 2023

Purpose. Increase of the competitiveness is the important scientific and practical task in machine building. The press is the stationary equipment, but reduction of weight of its elements, in particular – columns, reduces manufacturing cost, facilitates transportation and installation, therefore assists in increase of product attraction at market relations. The purpose is to reduce press column weight without complication of technological process of its manufacturing and without additional expenses for a concrete one-columned press by means of structure optimization.
Research methods. The mathematical model has been developed on the basis of formula of combined strength of materials. The pure bending with tension results from operation of one-columned press. Multicriterion optimization has been carried out by means of computer facilities. Calculation was carried out by means of the program written in language Basic.
Results. The press П6330 with box-shaped cross-section has been chosen as a base variant. The optimal geometrical dimensions have been determined for the offered T-shaped welded cross-section of a column. Technological process of manufacturing of such column is simplified.
Scientific novelty. The T-shaped welded column cross-section has been offered for the purpose of modernization. Such cross-section scheme is more perspective and technological. The following 3 criteria have been chosen at multicriterion optimization carrying out: equal strength with the base variant, the greatest uniformity of distribution of stress by cross-section, the least area of cross-section. The main geometrical dimensions of cross-section have been chosen as 4 variable parameters. It was considered, that thickness of metal sheet is discrete and standard.
Practical value. Multicriterion optimization that had been carried out provides reduction of column weight approximately by 45 % for the modernized variant without increase in dimensions of cross-section. It gives the opportunity to reduce considerably the column manufacturing cost in comparison with a base variant, and also to facilitate transportation and installation of the press.