bluuebunny/crossref_metadata_2025_split huggingface dataset:
High diet quality indices associated with lower risk of lipid profile abnormalities in Taiwanese kidney transplant recipients
Authors: Lin I-Hsin , Van Duong Tuyen , Nien Shih-Wei , Tseng I-Hsin , Wu Yi-Ming , Chiang Yang-Jen , Wang Hsu-Han , Chiang Chia-Yu , Wang Ming-Hsu , Chiu Chia-hui , Lin Ying-Tsen , Wong Te-Chih 
Published: November 2023

AbstractCardiovascular disease (CVD) and its risk factors seem to be linked with deteriorated graft function and persists as the major cause of mortality in kidney transplant recipients (KTRs). Diet quality is associated with CVD prevention in the healthy population, however, less study focuses on KTRs. The study aimed to determine the association between diet quality indices and lipid profile abnormalities as risk factors for CVD in KTRs. This prospective study enrolled 106 KTRs who had functioning allografts from September 2016. Lipid profiles included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG) and were based on the National Cholesterol Education Program Adult Treatment Panel III recommendations. Three-day dietary data were collected by a well-trained registered dietitian. The Alternative Healthy Eating Index-Taiwan (AHEI-Taiwan), Alternative Healthy Eating Index-2010 (AHEI-2010), and Healthy Eating Index-2015 (HEI-2015) scores were calculated and divided into quartiles and compared accordingly. KTRs’ mean LDL-C, HDL-C, TC, and TG levels were 119.8 ± 36.6 mg/dL, 52.0 ± 17.9 mg/dL, 205.8 ± 43.9 mg/dL, and 160.2 ± 121.6 mg/dL, respectively. Compared with the lowest quartile, only the highest quartile of AHEI-Taiwan had lower TC and LDL-C levels. After adjustment for age, gender, energy, Charlson comorbidity index, transplant duration, and dialysis duration, logistic regression analysis revealed that the highest quartile of AHEI-Taiwan had 82% (odds ratio [OR], 0.18; 95% confidence interval [CI] 0.04–0.72, p < 0.05) lower odds of high TC and 88% (OR 0.12; 95% CI 0.03–0.58, p < 0.05) lower odds of high LDL-C, and the highest quartile of HEI-2015 had 77% (OR 0.23; 95% CI 0.05–0.95, p < 0.05) lower odds of high LDL-C. Higher adherence to a healthy diet as per AHEI-Taiwan and HEI-2015 guidelines associated with lower risk of lipid profile abnormalities in KTRs.
Axillary mechanical circulatory support improves renal function prior to heart transplantation in patients with chronic kidney disease
Authors: Jang Ji-Min , Jarmi Tambi , Sareyyupoglu Basar , Nativi Jose , Patel Parag C. , Leoni Juan C. , Landolfo Kevin , Pham Si , Yip Daniel S. , Goswami Rohan M. 
Published: November 2023

AbstractImpaired kidney function is often associated with acute decompensation of chronic heart failure and portends a poor prognosis. Unfortunately, current data have demonstrated worse survival in patients with acute kidney injury than in patients with chronic kidney disease during durable LVAD placement as bridge therapy. Furthermore, end-stage heart failure patients undergoing combined heart-kidney transplantation have poorer short- and long-term survival than heart transplants alone. We evaluated the kidney function recovery in our heart failure population awaiting heart transplantation at our institution, supported by temporary Mechanical Circulatory Support (tMCS) with Impella 5.5. The protocol (#22004000) was approved by the Mayo Clinic institutional review board, after which we performed a retrospective review of all patients with acute on chronic heart failure and kidney disease in patients considered for only heart and kidney combined organ transplant and supported by tMCS between January 2020 and February 2021. Hemodynamic and kidney function trends were recorded and analyzed before and after tMCS placement and transplantation. After placement of tMCS, we observed a trend towards improvement in creatinine, Fick cardiac index, mixed venous saturation, and glomerular filtration rate (GFR), which persisted through transplantation and discharge. The average duration of support with tMCS was 16.5 days before organ transplantation. The median pre-tMCS creatinine was 2.1 mg/dL (IQR 1.75–2.3). Median hematocrit at the time of tMCS placement was 32% (IQR 32–34), and the median estimated glomerular filtration rate was 34 mL/min/BSA (34–40). The median GFR improved to 44 mL/min/BSA (IQR 45–51), and serum creatinine improved to 1.5 mg/dL (1.5–1.8) after tMCS. Median discharge creatinine was 1.1 mg/dL (1.19–1.25) with a GFR of 72 (65–74). None of these six patients supported with tMCS required renal replacement therapy after heart transplantation. Early adoption of Impella 5.5 in this patient population resulted in renal recovery without needing renal replacement therapies or dual organ transplantation and should be further evaluated.
Aircraft trajectory prediction and aviation safety in ADS-B failure conditions based on neural network
Authors: Yang Zhanji , Kang Xiaolei , Gong Yuanhao , Wang Jiansheng 
Published: November 2023

AbstractWith the rapid expansion of transportation demand, the number of global flights has rapidly increased, which also poses challenges to air traffic management (ATM). Considering that the radar system in ATM can no longer meet the requirements of flight safety, a very promising next-generation air traffic control technology—Automatic Dependent Surveillance Broadcast (ADS-B) technology has been introduced. However, in the event of on-board equipment failure and local area signal interference, the ADS-B’s signal will disappear or be interrupted. This sudden situation can pose a danger to aviation safety. To solve this problem, this article proposes a bidirectional long short-term memory (Bi-LSTM) network prediction method combining historical ADS-B data to short-term predict the trajectory of aircraft, which can improve aviation safety in busy airspace. Firstly, the problem of frequent dynamic modeling of different types of aircraft was solved by utilizing historical ADS-B data as the data source. Secondly, the data cleansing method is proposed for ADS-B raw data. Furthermore, considering that the spatial trajectory of the aircraft is a complex time series with continuity and interactivity, a bidirectional LSTM based aircraft trajectory prediction framework is proposed to further improve prediction accuracy. Finally, a trajectory with frequent changes was selected for prediction, and compared with 7 prediction methods. The results showed that the proposed method had high prediction accuracy, thus also improving the aviation safety of the aircraft.
Single-shot dynamics of dual-comb generation in a polarization-multiplexing fiber laser
Authors: Rodriguez Cuevas Alberto , Kudelin Igor , Kbashi Hani , Sergeyev Sergey 
Published: November 2023

AbstractDual optical frequency combs have been a recurrent case of study over the last decade due to their wide use in a variety of metrology applications. Utilizing a single cavity laser to generate a dual comb reduces system complexity and facilitates suppression of common noise. However, a dual-comb regime in single cavity lasers tends to be more unstable and difficult to achieve. Therefore, having a better understanding about the way they are generated could improve and automate their generation and control. In this paper, we investigate the build-up dynamics and collision of dual comb in a polarization-multiplexing ring-cavity fiber laser using DFT (Dispersive Fourier Transform) method. We observe a bunch of meta-stable short-lived mode-locking states before the laser entered the dual-comb mode-locking state. The energy level of this short-lived initial pulses determines its evolution. If it decreases too much, the pulse will eventually collapse while if it stays above certain level, it will be successfully generated. The results presented in this paper increase the understanding of dual-comb generation inside a single cavity laser and may contribute in future attempts to increase the stabilization of this regime.
MXene/AgNW composite material for selective and efficient removal of radioactive cesium and iodine from water
Authors: Mushtaq Sajid , Husnain Syed M. , Kazmi Syed Asad Raza , Abbas Yawar , Jeon Jongho , Kim Jung Young , Shahzad Faisal 
Published: November 2023

AbstractToxic fission products, such as cesium (137Cs) and iodine (129I) are of great concern because of their long half-lives and high solubility in water. The simultaneous removal of Cs and I using a single adsorbent is an area of increasing interest. In this study, MXene/silver nanowire (AgNW) composite was synthesized through physical mixing and employed for simultaneous removal of iodide (I−) and cesium (Cs+) ions from contaminated water. The MXene/AgNW composite demonstrated excellent adsorption capacities of 84.70 and 26.22 mg/g for I− and Cs+, respectively. The experimental data supported the hypothesis of multilayer adsorption of Cs+ owing to the inter-lamellar structures and the presence of heterogeneous adsorption sites in MXene. The interaction between I− and the AgNW involved chemisorption followed by monolayer adsorption. MXene/AgNW composite material exhibited promising results in the presence of competitive ions under extreme pH conditions. Thus, synthesized composite materials holds promising potential as an adsorbent for the remediation of radioactive liquid waste.
Imaging overpressurised fracture networks and geological barriers hindering fluid migrations across a slow-deformation seismic gap
Authors: Napolitano Ferdinando , Gabrielli Simona , De Siena Luca , Amoroso Ortensia , Capuano Paolo 
Published: November 2023

AbstractThere is an ongoing debate on the processes producing background seismicity and deformation transients across seismic gaps, i.e., regions that lack historical large-magnitude earthquakes. Essential missing elements are geophysical images that resolve sources of geophysical unrest. Here, we apply seismic scattering and absorption tomography to data recorded during the 2010–2014 seismic sequence within the Mt. Pollino seismic gap region (Southern Italy). The tomographic models show high sensitivity to fluid content, deformed fractured structures, and impermeable layers stopping fluid migrations. They bridge the gaps between geological and geophysical models and provide a highly-resolved image of the source of seismic and deformation unrest within this seismic gap. High absorption topping the western Pollino seismic volume appears pressurized between the low-Vp/Vs and low-scattering San Donato metamorphic core and a deep basement. Absorbing fluids can only migrate laterally to the east, blocked in the west and southwest by deep low-scattering barriers associated with east-dipping faults and to the north and southeast by saturated overpressurized low-scattering basins. This eastern migration is only partially effective, producing seismicity across the lowest boundary of the high-absorption volume. Our results showcase the potential of seismic scattering and absorption when imaging structures causing geophysical unrest processes across fault networks.
Identification and characterization of Glycolate oxidase gene family in garden lettuce (Lactuca sativa cv. ‘Salinas’) and its response under various biotic, abiotic, and developmental stresses
Authors: Mariyam  , Shafiq Muhammad , Sadiq Saleha , Ali Qurban , Haider Muhammad Saleem , Habib Umer , Ali Daoud , Shahid Muhammad Adnan 
Published: November 2023

AbstractGlycolate oxidase (GLO) is an FMN-containing enzyme localized in peroxisomes and performs in various molecular and biochemical mechanisms. It is a key player in plant glycolate and glyoxylate accumulation pathways. The role of GLO in disease and stress resistance is well-documented in various plant species. Although studies have been conducted regarding the role of GLO genes from spinach on a microbial level, the direct response of GLO genes to various stresses in short-season and leafy plants like lettuce has not been published yet. The genome of Lactuca sativa cultivar ‘Salinas’ (v8) was used to identify GLO gene members in lettuce by performing various computational analysis. Dual synteny, protein–protein interactions, and targeted miRNA analyses were conducted to understand the function of GLO genes. The identified GLO genes showed further clustering into two groups i.e., glycolate oxidase (GOX) and hydroxyacid oxidase (HAOX). Genes were observed to be distributed unevenly on three chromosomes, and syntenic analysis revealed that segmental duplication was prevalent. Thus, it might be the main reason for GLO gene diversity in lettuce. Almost all LsGLO genes showed syntenic blocks in respective plant genomes under study. Protein–protein interactions of LsGLO genes revealed various functional enrichments, mainly photorespiration, and lactate oxidation, and among biological processes oxidative photosynthetic carbon pathway was highly significant. Results of in-depth analyses disclosed the interaction of GLO genes with other members of the glycolate pathway and the activity of GLO genes in various organs and developmental stages in lettuce. The extensive genome evaluation of GLO gene family in garden lettuce is believed to be a reference for cloning and studying functional analyses of GLO genes and characterizing other members of glycolate/glyoxylate biosynthesis pathway in various plant species.
The neutrophil-to-lymphocyte ratio is associated with the frequency of delayed neurologic sequelae in patients with carbon monoxide poisoning
Authors: Xu Dawei , Mei Tianshu , He Fei 
Published: November 2023

AbstractDelayed neurologic sequelae (DNS) is a common complication in patients with carbon monoxide poisoning (COP). We aimed to investigate the association of the neutrophil-to-lymphocyte ratio (NLR) with the frequency of DNS in COP patients. A total of 371 COP patients were investigated in retrospective and prospective studies. A receiver operator curve (ROC) test was performed to evaluate the ability of the NLR to predict DNS in COP patients. The retrospective study included 288 COP patients, of whom 84 (29.2%) were confirmed to have DNS, and 1 (0.3%) died within 28 days. The NLR in the DNS group was significantly higher than that in the non-DNS group (6.84 [4.22–12.43] vs. 3.23 [1.91–5.60] × 109/L). NLR was a significant predictor of the frequency of DNS [odds ratio (OR): 1.130, 95% confidence interval (CI): 1.030, 1.240] in COP patients. The area under the ROC curve of NLR for predicting DNS was 0.766 (95% CI 0.701, 0.832), and the cut-off value was 3.745 (sensitivity, 83.3%; specificity, 58.8%). The prospective study included 83 COP patients, of whom 19 (22.9%) were confirmed to have DNS, and all patients survived. Moreover, the frequency of DNS in the patients with an NLR ≥ 3.745 was notably higher than that in the patients with an NLR < 3.745 [41.4% (12/29) vs. 13.0 (7/54)]. In conclusion, the NLR was a significant, independent predictor of the frequency of DNS in COP patients.
Cardiomyocyte-specific disruption of the circadian BMAL1–REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart
Authors: Latimer Mary N. , Williams Lamario J. , Shanmugan Gobinath , Carpenter Bryce J. , Lazar Mitchell A. , Dierickx Pieterjan , Young Martin E. 
Published: November 2023

AbstractCircadian disruption increases cardiovascular disease (CVD) risk, through poorly understood mechanisms. Given that small RNA species are critical modulators of cardiac physiology/pathology, we sought to determine the extent to which cardiomyocyte circadian clock (CCC) disruption impacts cardiac small RNA species. Accordingly, we collected hearts from cardiomyocyte-specific Bmal1 knockout (CBK; a model of CCC disruption) and littermate control (CON) mice at multiple times of the day, followed by small RNA-seq. The data reveal 47 differentially expressed miRNAs species in CBK hearts. Subsequent bioinformatic analyses predict that differentially expressed miRNA species in CBK hearts influence processes such as circadian rhythmicity, cellular signaling, and metabolism. Of the induced miRNAs in CBK hearts, 7 are predicted to be targeted by the transcriptional repressors REV-ERBα/β (integral circadian clock components that are directly regulated by BMAL1). Similar to CBK hearts, cardiomyocyte-specific Rev-erbα/β double knockout (CM-RevDKO) mouse hearts exhibit increased let-7c-1-3p, miR-23b-5p, miR-139-3p, miR-5123, and miR-7068-3p levels. Importantly, 19 putative targets of these 5 miRNAs are commonly repressed in CBK and CM-RevDKO heart (of which 16 are targeted by let-7c-1-3p). These observations suggest that disruption of the circadian BMAL1–REV-ERBα/β regulatory network in the heart induces distinct miRNAs, whose mRNA targets impact critical cellular functions.
Skeletal muscle cells opto-stimulation by intramembrane molecular transducers
Authors: Venturino Ilaria , Vurro Vito , Bonfadini Silvio , Moschetta Matteo , Perotto Sara , Sesti Valentina , Criante Luigino , Bertarelli Chiara , Lanzani Guglielmo 
Published: November 2023

AbstractOptical stimulation and control of muscle cell contraction opens up a number of interesting applications in hybrid robotic and medicine. Here we show that recently designed molecular phototransducer can be used to stimulate C2C12 skeletal muscle cells, properly grown to exhibit collective behaviour. C2C12 is a skeletal muscle cell line that does not require animal sacrifice Furthermore, it is an ideal cell model for evaluating the phototransducer pacing ability due to its negligible spontaneous activity. We study the stimulation process and analyse the distribution of responses in multinuclear cells, in particular looking at the consistency between stimulus and contraction. Contractions are detected by using an imaging software for object recognition. We find a deterministic response to light stimuli, yet with a certain distribution of erratic behaviour that is quantified and correlated to light intensity or stimulation frequency. Finally, we compare our optical stimulation with electrical stimulation showing advantages of the optical approach, like the reduced cell stress.
Taming the perils of photosynthesis by eukaryotes: constraints on endosymbiotic evolution in aquatic ecosystems
Authors: Miyagishima Shin-ya 
Published: November 2023

AbstractAn ancestral eukaryote acquired photosynthesis by genetically integrating a cyanobacterial endosymbiont as the chloroplast. The chloroplast was then further integrated into many other eukaryotic lineages through secondary endosymbiotic events of unicellular eukaryotic algae. While photosynthesis enables autotrophy, it also generates reactive oxygen species that can cause oxidative stress. To mitigate the stress, photosynthetic eukaryotes employ various mechanisms, including regulating chloroplast light absorption and repairing or removing damaged chloroplasts by sensing light and photosynthetic status. Recent studies have shown that, besides algae and plants with innate chloroplasts, several lineages of numerous unicellular eukaryotes engage in acquired phototrophy by hosting algal endosymbionts or by transiently utilizing chloroplasts sequestrated from algal prey in aquatic ecosystems. In addition, it has become evident that unicellular organisms engaged in acquired phototrophy, as well as those that feed on algae, have also developed mechanisms to cope with photosynthetic oxidative stress. These mechanisms are limited but similar to those employed by algae and plants. Thus, there appear to be constraints on the evolution of those mechanisms, which likely began by incorporating photosynthetic cells before the establishment of chloroplasts by extending preexisting mechanisms to cope with oxidative stress originating from mitochondrial respiration and acquiring new mechanisms.
Toward conformational identification of molecules in 2D and 3D self-assemblies on surfaces
Authors: Hamadeh Ali , Palmino Frank , Mathurin Jérémie , Deniset-Besseau Ariane , Grosnit Louis , Luzet Vincent , Jeannoutot Judicaël , Dazzi Alexandre , Chérioux Frédéric 
Published: November 2023

AbstractThe design of supramolecular networks based on organic molecules deposited on surfaces, is highly attractive for various applications. One of the remaining challenges is the expansion of monolayers to well-ordered multilayers in order to enhance the functionality and complexity of self-assemblies. In this study, we present an assessment of molecular conformation from 2D to 3D supramolecular networks adsorbed onto a HOPG surface under ambient conditions utilizing a combination of scanning probe microscopies and atomic force microscopy- infrared (AFM-IR). We have observed that the infrared (IR) spectra of the designed molecules vary from layer to layer due to the modifications in the dihedral angle between the C=O group and the neighboring phenyl ring, especially in the case of a 3D supramolecular network consisting of multiple layers of molecules.
Long-period directivity pulses of strong ground motion during the 2023 Mw7.8 Kahramanmaraş earthquake
Authors: Čejka František , Zahradník Jiří , Turhan Fatih , Sokos Efthimios , Gallovič František 
Published: November 2023

AbstractDamages due to large earthquakes are influenced by broadband source effects that remain enigmatic. Here we develop a broadband (0–10 Hz) source model of the disastrous 2023 Mw7.8 Kahramanmaraş, Türkiye, earthquake by modeling recordings of 100 stations. The model combines coherent and incoherent rupture propagation at low and high frequencies, respectively. We adopt a planar 300 km long kinked fault geometry from geology and pre-constrain the slip model from seismic and geodetic data. We demonstrate that the southwestward rupture propagation was delayed by ~15 s and that the observed strong waveform pulses can be explained by the directivity effect due to a specific combination of the coherent and incoherent components. We show that even a rough estimate of major rupture parameters makes the ground motion simulations of such large events possible, and may thus improve the efficiency of rapid, physics-based, shaking estimation for emergency response and seismic hazard assessment.
External condition-induced interfacial charge transfer in single-walled carbon nanotube/graphene van der Waals heterostructures
Authors: Yin Huan , Zhang Ruxuan , Tian Tian , Yang Zhi , Hu Nantao , Zhang Yafei , Su Yanjie 
Published: November 2023

The external conditions interfacial charge transfer in SWCNT/graphene van der Waals heterostructures was systematically investigated by Raman spectroscopy and the mechanism was deduced by the trend of changes in Raman characteristic peaks.
Chronic Drug-Induced Liver Injury from Labetalol during the Postpartum Period: A Case Report
Authors: Lee Bruce , Xiong Suriya , Westen Elizabeth A. , Warner Julie Ann 
Published: November 2023

AbstractDrug-induced liver injury (DILI) is a common cause of transaminitis in pregnancy. A 34-year-old G3P2012 presented 3 weeks postpartum for preeclampsia with severe features. After receiving acute antihypertensive medications, she was discharged home with labetalol. She presented 5 months later with general malaise, scleral icterus, nausea, and mild right upper quadrant pain and found to have significantly elevated transaminitis. She had a negative infectious, autoimmune, biliary, and steatohepatitis workup. A liver biopsy was performed supporting the diagnosis of DILI. After patient self-discontinued labetalol, her hepatitis significantly improved. However, she developed chronic DILI and liver enzymes normalized during her subsequent pregnancy at 34 weeks. Patient's written consent was obtained for this case report. Chronic DILI secondary to labetalol use is a rare and potentially fatal condition that should be considered on the differential for transaminitis during pregnancy and postpartum period.