bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Genomic Analyses Reveal Putative Cell Type-specific Targets of the Drosophila Ets Transcription Factor Pointed
Authors: Raja Komal Kumar Bollepogu , Yeung Kelvin , Shim Yoon-Kyung , Mardon Graeme 
Published: November 2023

Abstract
The Ets domain transcription factors direct diverse biological processes throughout all metazoans and are implicated in development as well as in tumor initiation, progression and metastasis. The Drosophila Ets transcription factor Pointed (Pnt) is the downstream effector of the Epidermal growth factor receptor (Egfr) pathway and is required for cell cycle progression, specification, and differentiation of most cell types in the larval eye disc. Despite its critical role in development, very few targets of Pnt have been reported previously. Here, we employed an integrated approach by combining genome-wide single cell and bulk data to identify putative cell type-specific Pnt targets. First, we used chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq) to determine the genome-wide occupancy of Pnt in late larval eye discs. We identified enriched regions that mapped to an average of 6,941 genes, the vast majority of which are novel putative Pnt targets. Next, we integrated ChIP-seq data with two other larval eye single cell genomics datasets (scRNA-seq and snATAC-seq) to reveal 157 putative cell type-specific Pnt targets that may help mediate unique cell type responses upon Egfr-induced differentiation. Finally, our integrated data also predicts cell type-specific functional enhancers that were not reported previously. Together, our study provides a greatly expanded list of putative cell type-specific Pnt targets in the eye and is a resource for future studies that will allow mechanistic insights into complex developmental processes regulated by Egfr signaling.
A rumor propagation model based on nuclear fission
Authors: Zheng Wenrong , Liu Fengming , Sun Yingping 
Published: November 2023

Abstract
The spread of online rumors is rapid, and its transmission mechanism has always been a research difficulty. In this paper, the network rumors are compared to the nuclear fission process, and the network rumors propagation model is constructed. Firstly, the initial online rumors are compared to neutrons, uranium nuclei are compared to individual rumor receivers, and fission barriers are compared to individual active propagation thresholds; Secondly, the process of nuclear fission is analyzed, and the degree of energy accumulation is used to compare the social impact of online rumors. Finally, the online rumor propagation model based on nuclear fission is constructed. Through experimental simulation, it has been shown that compared to classic infectious disease models, this model can better describe the spread process of rumors in social networks. Through research and analysis, suggestions for suppressing rumors have been proposed, providing new ideas and references for future researchers.
Prediction of local failure for post-operative radiotherapy of resected brain metastases in breast cancer patients
Authors: haisraely Ory , symon zvi , kaisman-elbaz tehila , lawerence yaacov , ben-ayun Maoz , whol anton , dubinsky sergi , cohen zvi , globus ofer , taliansky alisa 
Published: November 2023

Abstract
Background Single brain metastasis surgical resection remains an effective treatment for brain metastases. However, surgery alone associate with a high rate of local failure. The current guidelines recommend radiation to surgical cavity. The recommended dose for brain cavity after surgery remain to be define as most guidelines gives a very general suggestion about the dose and fractionation. The aim of this study was to determine what variable influence local control in this specific population.Methods Retrospective analysis of 52 patients with breast cancer who undergo surgical resection to single brain metastases and who received post-operative radiotherapy between the years 2010–2022. All clinical and dosimetric variables were analyzed to evaluate their impact on local control. A predictive model for local control was calculated.Results One year local control was 65.3%. HER-2 disease, size of initial tumor, time from initial surgery, total dose deliver and the type of lesion were all significant for local control. The most important variable was total dose deliver. A specific nomogram using 7 parameters for a prediction of local was computed.Conclusion Brain metastases from breast cancer remain a life-threating condition. Surgery plays a critical role in the treatment of large symptomatic brain metastases for which Post-operative radiotherapy is essential. Choosing a regime of 5 fraction with a dose of 30Gy (BED4 > 70Gy) seem important for achieving local control and without increase toxicity.
Enhancing Data Security in Cloud Computing with Optimized Feature Selection and Machine Learning for Intrusion Detection
Authors: Kavitha S , Gadde Swetha , Thatikonda Ramya , Vaddadi Srinivas Aditya , Naresh E , Pareek Piyush Kumar 
Published: November 2023

Abstract
The major objective of this project is to create a Machine Learning (ML) model that can improve data security when data is transported or handled utilizing cloud computing. Researchers must develop a model or a strategy that can secure the data because cloud computing is one of the fastest-growing technologies. This study employs a data set made up of several parameters that can help ML models improve the security of the data for this goal. Then, using a variety of methods, this data set is prepossessed. Following feature extraction, when the parameters are left out, the preprocessed data is then provided to the message learning models. The ML models are then trained and tested using these exclusive parameters. For greater efficiency, three separate learning metrics and three different ML models are created. They are the Artificial Neural Network (ANN) algorithm, the K-nearest neighbor (KNN) algorithm, and the Random Forest (RF) algorithm. The models' testing and training are then used to compare their efficacy. For this reason, the outcomes of both training and testing are noted and examined. The ideal measuring methodology for improving data security is found using parameters like precision, true positive rate, false negative rate, etc. The effectiveness of the feature extraction technique is tabulated alongside the ML models to determine the optimal feature extraction technique and ML model combination. In the end, it is discovered that the ANN algorithm combined with a simulated bee colony may generate the highest level of efficiency. This model's output has a final accuracy of 93.8%. As a result, this approach can be used in conjunction with applications that call for cloud computing, improving data security in the process.
“A part of my life”. A qualitative study about perceptions of female genital mutilation among affected women residing in Sweden
Authors: Eshraghi Bita , Marions Lena , Berger Cecilia , Berggren Vanja 
Published: November 2023

Abstract

Background Female genital mutilation (FGM) is defined as all procedures involving partial or total removal of the external female genitalia, or other injuries to them for non-medical reasons. Due to migration, healthcare providers in high-income countries need to better understand the consequences of FGM. The aim of this study was to elucidate women’s experiences of FGM, with particular focus on perceived health consequences and experiences of healthcare received in Sweden.Methods A qualitative study was performed through face-to-face, semi-structured interviews with eight women who had experienced FGM in childhood, prior to immigration to Sweden. The transcribed narratives were analyzed using content analysis.Results Three main categories emerged: “Living with FGM”, “Living with lifelong health consequences” and “Encounters with healthcare providers”. The participants highlighted the motives behind FGM and their mothers' ambivalence in the decision process. Although the majority of participants had undergone FGM type 3, the most severe type of FGM, the lifelong health consequences were diverse. Poor knowledge about FGM, insulting attitude, and lack of sensitive care were experienced when seeking healthcare in Sweden.Conclusions Our findings indicate that FGM is a complex matter causing a diversity in perceived health consequences in women affected. Increased knowledge and awareness about FGM among healthcare providers in Sweden is of utmost importance. Further, this subject needs to be addressed in the healthcare encounter in a professional way.
Digital Twins: Facilitating Digital Transformation From and Beyond BIM in Construction
Authors: Afzal Muhammad , Khan Asmat Ullah , Bilal Muhammad , Ayyub Muhammad Faisal , Shoaib Muhammad 
Published: November 2023

Abstract
Industry 4.0 technologies are revolutionizing conventional practices across various sectors and stand at the forefront of digital transformation within these industries. Building Information Modeling (BIM) technology has modernized the construction sector, an industry known for low innovation but high GDP contribution, over the last few years. The adoption of Digital Twins (DT) technology is now enriching BIM, particularly in addressing the dynamic aspects of construction processes. This empowers the utilization of real-time data for more resilient data-driven practices, resulting in heightened productivity and accelerated progress in digital transformation. A systematic review is imperative as the construction industry needs to keep up with the fast-paced digital economy. Therefore, this paper aims to investigate the status of digital transformation by using the PRISMA methodology for systematic review. The Scopus database was referred to using specific keywords, and 52 documents were obtained and filtered to 15 final records. Literature analysis about DT-driven digitalization in construction provides insights into the transitional stages and pillars guiding the digital transformation phenomenon. This study will provide valuable insights into the future DT trends in the sector and enable the realization of digitalization in the construction industry.
Presentación atípica del Síndrome de Guillain Barré en pediatría. Reporte de caso
Authors: Suárez – Silva Daniel Felipe , Cárdenas – Silva Angie Milena , Benavides – Benavides Ramiro José 
Published: November 2023

Las variantes atípicas del Síndrome de Guillain Barré (SGB) incluyen debilidad y síntomas sensitivos asimétricos, de predominio distal o proximal, dolor difuso o compromiso aislado de pares craneales previo al inicio de los síntomas, irritabilidad, meningismo y marcha inestable. Objetivo: describir el siguiente caso de SGB de presentación atípica en un paciente pediátrico dada por debilidad asimétrica, alteración de la marcha y compromiso unilateral del XII par craneal. Caso Clínico: adolescente masculino afrocolombiano, con hemiparesia izquierda de inicio distal, alteración de la marcha, ataxia, dificultad para la elevación y lateralización izquierda de la lengua. El diagnóstico se apoyó en el estudio de líquido cefalorraquídeo con disociación albumino citológica, resonancia magnética que mostró realce de raíces nerviosas y estudios de neuroconducción compatibles con polineuropatía de tipo axonal en miembros inferiores. Conclusiones: las presentaciones atípicas del SGB constituyen un reto diagnóstico, la debilidad asimétrica y el compromiso de XII par craneal obligan a descartar otras patologías. La historia clínica y el examen físico apoyados en estudios complementarios de líquido cefalorraquídeo, neuroimagen y neuroconducción son útiles para confirmar SGB. El conocimiento de las variables atípicas de SGB en la población pediátrica es indispensable para la identificación oportuna y tratamiento precoz.
Embolia sistémica a partir de placa aterosclerótica con trombo móvil aórtico: reporte de caso
Authors: Arango Martínez Alejandro , Solano Villamarín Alejandra , Duarte Vásquez Juan Carlos , Herrera Ramos Rafael  Ignacio , Arrieta Bechara Juan Carlos 
Published: November 2023

Introducción: la isquemia arterial aguda se reconoce como un síndrome clínico potencialmente mortal relacionado con trombosis o embolia sistémica. La aorta es la fuente del 5 % de todos los casos de embolia y suele relacionarse con factores de riesgo ateroescleróticos. Actualmente no existen guías unificadas que establezcan el tratamiento óptimo de esta entidad. Presentación del caso: masculino de 70 años, con antecedente de tabaquismo, acude al servicio de urgencias por 2 meses de dolor en miembros inferiores, parestesias, palidez, frialdad. Se documenta una isquemia arterial aguda, se inicia anticoagulación y se lleva a trombólisis de vasos poplíteos, posteriormente presenta múltiples eventos embólicos, se documenta la presencia de una placa ulcerada en aorta con un gran trombo móvil, se platea terapia híbrida (endovascular y cirugía abierta), sin embargo, desarrolla nuevas embolias y muere. Conclusiones: la aorta debe considerarse como fuente embólica, debe realizarse un enfoque diagnóstico juicioso y establecer una adecuada indicación de anticoagulación e intervención quirúrgica apropiada.
Estimating the vulnerability of groundwater resources to diffuse pollution in highlands areas: review of the literature and critical analysis (highlands of Cameroon)
Authors: Djatsa Nguedia Kevin , Ntankouo Njila Roger , Ndongo Barthelémy , Choumele Jiague Ronny Roy , Lotse Tedontsah Vivien Piercy , Kagou Dongmo Armand 
Published: November 2023

Abstract

Groundwater is a major resource for drinking water, especially in developing countries, where it is less expensive to treat than surface water. Today, the resource is highly susceptible to pollution, particularly as a result of human activity. This review was based on a literature review and critical analysis of models for estimating the groundwater vulnerability. The results show that the deepest porous aquifers are the least susceptible to pollution, whereas those in karstic and fissured environments are susceptible, whatever their depth. Pollution usually arises from human activity. Critical analysis of the literature shows that existing methods are developed in specific environmental contexts. Given the variability of factors in space and time, these methods do not take the intrinsic realities of all natural settings into account adequately and are not perfectly applicable in all environments. This highlights the need to develop appropriate models for each environment, such as that of the highlands in countries such as Cameroon.
Synergy effect in blend Orange G/Rhodamine B ultrafiltration, using natural bentonite-based membrane
Authors: Labied Radia , Touahra Fouzia , Hazam Souad , Ouraghi Maâmar , Chebout Redouane , Bachari Khaldoun , Lerari Djahida 
Published: November 2023

Abstract

Attempting to reduce issues with dumping and water pollution, bio-based membrane material (MB1000), based on bentonite was elaborated for application in tangential ultrafiltration. For this, morphological properties, textural properties, and chemical structure of the elaborated membrane material were established using Fourier transform infrared spectroscopy, X-ray diffraction, and Brunauer–Emmett–Teller analyses. Water permeability, chemical resistance, as well as point of zero charge of the membrane material were also investigated. The studied membrane material has a mesoporous structure, with a pore size of 7.20 nm and a water permeability of 318.06 L/h.m2.bar. The effect of transmembrane material pressure, pH solution, and concentration on Orange G (OG) and Rhodamine B (RB) dye rejection efficiency was examined and hence optimized. Besides, a mixture of RB and OG dyes was tested for membrane material ultrafiltration in a simultaneous system (RB/OG). Remarkably, an enhancement of the rejection results was noticed for the two dyes (ROG = 94.33%, RRB = 89.38%) resulting from a synergic effect of hydrogen bonding as well as electrostatic interactions generated from functional groups of the molecules dyes.
Fraction analysis of soil phosphorus and dissolved organic matter reveals the release potential of phosphorus and its influencing factors in the submerged area of the Sanhekou Reservoir, China
Authors: Ge Zhengkui , Luo Shaojiang , Wang Qi , Li Ming 
Published: November 2023

Abstract
Different forms of inorganic phosphorus in surface soils can be released into water or adsorbed into sediment in response to various environmental factors. Although the Sanhekou Reservoir is still under construction, the periodic wetting-drying events may result in the release of inorganic phosphorus from the soil into the water once it is completed. Therefore, this study aimed to investigate the background soil values and estimate the phosphorus release fluxes of the Puhe River, Wenshuihe River, and Jiaoxihe River of the reservoir. We would like to provide a theoretical basis for the subsequent management and ecological protection of the reservoir based on this study. The Chang–Jackson chemical continuous extraction method was used to determine the forms of inorganic phosphorus in the soil, and fluorescence data were obtained by excitation–emission matrix combined with parallel factor (EEM-PARAFAC). The results showed that there were four types of phosphorus in the soil of the reservoir, including calcium-bound phosphate, aluminium-bound phosphate, iron-bound phosphate, and occluded phosphate. The total quantities of these phosphorus types were measured to be 6.71 × 104, 1.14 × 104, 0.91 × 104, and 0.49 × 104t, respectively. Additionally, it was observed that there was 2.12 × 104 t of bioavailable phosphorus present in the soil.
Effect of carboxyl and hydroxyl groups attached to the benzene ring on the photodegradation of polycyclic aromatic hydrocarbons in ice
Authors: Jiang Caihong , Xue Shuang , Zhang Jinming , Zhang Zhaohong , Yu Yingtan , Liu Jiyang 
Published: November 2023

Abstract

The effect of carboxyl and hydroxyl groups attached to the benzene ring on the photodegradation of anthracene (Ant) and pyrene (Pyr) in ice was investigated. The present study aims to explore the inhibition mechanism of five dissolved organic matter (DOM) model compounds’ materials such as benzoic acid, o-hydroxybenzoic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, and 3-phenyl propionic acid on the degradation of Ant and Pyr in ice. The photodegradation rate of Ant and Pyr were 50.33 and 37.44% in ice, with the photodegradation rate of Ant being greater than that of Pyr. The five DOM model compounds inhibited the photolysis of Ant and Pyr, and the influence mechanism on the photodegradation of Ant and Pyr depended upon the types and positions of functional groups on the benzene. Among them, the structure in which the carboxyl group was directly connected to the benzene ring and carboxyl was located at the ortho position of a hydroxy group had a strong inhibitory effect on the photodegradation of Ant and Pyr. Light-screening effects and quenching effects were the main inhibiting mechanism, and the binding ability of DOM model compounds material and PAHs is dominantly correlated with its inhibiting effect.
Andragogy of the Transformation of Thinking in Management in the Digital Age
Authors: Neizvestny S. I. , Slavin B. B. , Kuchmezov Kh. Kh. 
Published: November 2023

Relevance of the study. Any industrial revolution, any global innovation faces resistance caused by the fundamental properties of the human psyche – a wary attitude to change, fear of introducing innovations, distrust of future uncertainty. The modern stage of society's development is no exception – the transition to digitalization, which has caused hidden and sometimes open Luddism.The purpose of the study is to investigate and analyze trends in managerial thinking in the era of digitalization. In the current business environment, the pressing issue seems to be how to overcome misunderstandings and counteraction to everything that digitalization entails?The results of the study. Analysis of the best global and national practices of digital transformation shows that in order to reduce internal transaction costs, resistance to innovation, it is necessary first to change the way of thinking of enterprise management, business management. The paper briefly discusses the main trends in the management thought of project activities in recent years. It is shown that during the peak of attention to automation information technologies, management efforts were directed to assessing the quality of the final result of the project. The next stage of the analyzed period is characterized by a shift of attention to the quality of processes. And recent trends show the concentration of organizational and methodological resources primarily on the quality of competence of participants in the processes of project activity. In this trend, there has recently been a need to shift attention from technical and contextual competencies (IQ) to behavioral (EQ).
Emerging Treatment Options of Pluronic in Designing Colloidal Nano and
Microcarriers Carriers for Various Therapies
Authors: Mathur Pooja , Verma Ravinder , Rani Laxmi , Kamboj Sweta , Kamboj Rohit , Kamboj Tanu , Bhatt Shailendra 
Published: November 2023

Abstract:
Poloxamers, commonly known as Pluronics, are a special family of synthetic tri-block copolymers with a core structure made of hydrophobic poly (propylene oxide) chains sandwiched by
two hydrophilic poly (ethylene oxide) chains. It is possible to modify the mechanical, bioactive, and
microstructural characteristics of Pluronics to simulate the behavior of different types of tissues. Additionally, they are auspicious drug carriers with the capacity to increase therapeutic agent availability and to design nano-drug formulations for various ailments. The nanoformulation composed of
Pluronics is more susceptible to cancer cells due to their amphiphilic nature and feature of selfassembling into micelles. Today's expanding poloxamer research is creating new hopes that increase
the possibility of new remedies for a brand-new nanomedicine age treatment. This article provides a
concise overview of the classification, grading, and attributes of drug delivery systems (DDSs) as
well as the potential for Pluronics to create micro and nanocarriers. We subsequently discuss its utility in drug delivery for cancer, gene therapy, anti-infective therapy, antioxidants, anti-diabetic drugs,
anti-HIV, Alzheimer's disease, and antimicrobial drugs. This review also highlighted several patented
formulations that contain various grades of Pluronics in one or more different ways. The recent findings in fundamental research in the field properly demonstrate the strong interest in these novel
pharmaceutical strategies.