bluuebunny/crossref_metadata_2025_split huggingface dataset:
Untargeted massspectrometry based lipidomics analysis reveals altered lipid profiles in a scribble knockdown-induced colorectal cancer model of Drosophila
Authors: Kumar Rohit , Fatima Zeeshan , Kumar Pradeep , Kumar Prabhat , Chauhan Brijesh Singh , Srikris Saripella 
Published: January 2024

Abstract

Cancer alters host metabolism to meet its nutritional demands. The role of lipids and their association with colorectal cancer (CRC) remains elusive. Scribble (Scrib) is a cell polarity regulator protein that also functions as a tumor suppressor. Scrib dysregulation has been reported in various advanced cancers, including CRC.In this study, we used tissue-specific GAL4-UASRNAi to knockdown Scrib in the Drosophila hindgut. Scrib knockdown led to the development of a CRC-like phenotype. Lipid droplets were enlarged in the adult fat body with tumor induction. We employed LC-MS-based untargeted lipidomics to explore global lipid changes in Scrib knockdown flies.Our analysis revealed alterations in total lipids, with 63 lipids upregulated, 48 downregulated, and 120 unaffected. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) revealed striking differences between wild-type and Scrib knockdown flies. Volcano plot analysis revealed that TAG 54:2, PIP2 35:6, PIP2 34:5, FFA 6:1, and PIP 37:2 were the top five significantly upregulated lipids, while TAG 52:1, GM3 38:2;3, GlcdE 2:6, PIP2 37:4, and PIP2 37:2 were the top five significantly downregulated lipids.Receiver operating characteristic (ROC) curve analysis identified TAG 54:2, PIP2 35:6, and PIP 42:2 as promising biomarker candidates.In summary, our results highlight the value of integrating LC-MS-based lipidomics with machine learning algorithms to explore significant lipid alterations at an organismal level in Scrib knockdown flies. These findings open avenues to investigate cancer-lipid interactions in CRC and related human cancers, potentially shedding light on new diagnostic and therapeutic opportunities.
Study the effect of the static magnetic field on some blood parameters of male rats:In vivo
Authors: Al-Dulamey Qusay kh. , Najim Laith A. , Al-Jawwady Yasir A. , altaii ‬‏Hiyam adel 
Published: January 2024

Abstract
The goal of the current study was to determine how magnetic field that is constant affected male rat rates of growth, Plasmatic protein concentrations, hematopoiesis, the levels of glucose and Dehydrogenase of lactate (LDH) activity, transaminase activity. Rats were sub acutely exposed to SMF for 8 days in a row for 2 hour each day at 140 mT, which resulted in an increase in plasma LDH activity (+ 29%). Moreover, the glucose concentration increased by(+ 29%) and platelet number (+ 9%) while the hematological parameters, protein levels, and the activity of the enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) remained the same. Rats exposed to SMF for 16 days in a row (2hour/day at 140 mT) experienced significant growth rate significant increases in hemoglobin Hb (+ 9%) total plasma protein TP (+ 25%) glucose concentration (+ 37%) hematocrit levels Ht (+ 16%) platelet number PLT (+ 11%) Lactate dehydrogenase LDH (+ 29%) aspartate aminotransferase AST (+ 16%) alanine transaminase ALT(+ 17%). Rats exposed to SMF for 32 days in a row (2hour/day at 140 mT) experienced more significant growth rate significant increases in hemoglobin (+ 18% ), total plasma protein (+ 40%) cell of red blood (+ 18%), cell of white blood (+ 18%), and number of platelet (+ 16%) levels. The activities of LDH were likewise elevated by sub-chronic exposure to SMF. The concentration of glucose, however, was unaltered. This study was carried out with the objective of investigating the influences of stationary magnetic wave on growth enhancement, hematopoiesis, plasmatic protein data, glycaemia, of lactate dehydrogenase (LDL) and transaminases(alanine and aspartate aminotransferase data .
A Smart System to Detect Bike Accidents and Reduce Casualties
Authors: Ridwan A. E. M , Mary Mekhala Mariam , Rana Shohag , Islam Md. Motaharul 
Published: January 2024

Abstract
In this world people are a victim of traffic accidents so easily. It turns out more crucial when they cannot reach out for help. Overcrowdedness and ignorance of traffic rules and regulations are the main reasons for such accidents. The number of bikes in Dhaka has expanded dramatically as a result of the increased popularity of ride-sharing apps such as Pathao, Uber Moto, Shohoz, and others. As a result, bike accidents have become an everyday phenomenon. We have felt the need for an improved bike safety system that ensures bikers' proper emergency services. In this paper, we have proposed a system that constantly detects bike accidents using the MPU6050, SIM808, Raspberry Pi, and Arduino Uno. We also have used a USB camera to record the previous 30 seconds of the accident to identify the reason behind this misfortune. Furthermore, we have used a database to locate the nearest hospital for assistance. If an accident occurs, the sensors will trigger, capture the video information of why the accident has occurred, and send a message containing the number and location of the biker to the nearest hospitals, police stations, and emergency contacts.
SymProFold - Structural prediction of symmetrical biological assemblies
Authors: Buhlheller Christoph , Sagmeister Theo , Grininger Christoph , Gubensäk Nina , Sleytr Uwe B. , Usón Isabel , Pavkov-Keller Tea 
Published: January 2024

Abstract
Symmetry in nature often arises from self-assembly processes and serves a function. Our automated pipeline SymProFold leverages the high accuracy of the AlphaFold-Multimer predictions to derive symmetrical assemblies like two-dimensional S-layer arrays or spherical viral capsids from their protein sequence, verified with available experimental data on the cellular level. S-layers, found on many bacterial and archaeal cells, are vital for facilitating cell adhesion, evading the immune system, and providing protection against stress. However, their experimental structural characterization remains challenging because of their self-assembly property and high sequence variability. SymProFold now offers new avenues for exploring functionalities and designing targeted applications in diverse fields like nanotechnology, biotechnology, medicine, and material and environmental sciences.
MANAGEMENT OF CROUP IN CHILDREN: A CASE REPORT
Authors: Susanto Wenly , Novia Bella Rianto  , Dewa Agung Ayu Sridharaswari  
Published: December 2023

Background Croup is a viral respiratory disease in children that attacks the larynx and trachea causes obstruction or blockage of the upper respiratory tract which, if severe, can be life-threatening. Diagnosis of respiratory tract infection in children requires keen clinical vigilance to understand the risk of airway obstruction and the possible need for prompt intervention. Clinical symptoms in croup usually fever, runny nose, painful swallowing, and mild cough. This condition can develop into a loud, hoarse and harsh cough. Recognition of signs and symptoms is very important to prevent morbidity and mortality.
Objective To describe diagnosis and management of croup in children.
Case Description A 3-year-old boy, came to the emergency room with complaints of sudden shortness of breath this morning accompanied by fever and a barking cough. These complaints had been felt for 3 days before going to the hospital, but they can reduce on their own and according to the parents there were no danger signs for complaints in their children.
Conclusion Croup is a self-limited disease, but sometimes it tends to be severe and even fatal. Prompt and appropriate management can prevent or reduce the risk of croup morbidity and mortality in children .
Academic dishonesty: motivations of accounting students
Authors: Santos Neto Aloísio Ventura dos , Bonfim Mariana Pereira , Silva César Augusto Tibúrcio 
Published: January 2024

Purpose: Understanding the motivations for the occurrence of academic dishonesty in university Accounting students.
Methodology: Applying a survey based on the research by Ives et al. (2016) on 83 Accounting students from Rio de Janeiro. The Kuder-Richardson test was applied to verify the instrument's internal consistency. Subsequently, Pearson's chi-square test was performed.
Results: The results indicate that age and gender have little influence on dishonesty, while the period students are studying has an influence; that is, the longer the length of stay, the greater the dishonesty. It is also noteworthy that the students confessed to having seen more dishonest acts than they practiced, demonstrating that it is easier to admit that they have seen other people being dishonest than to confess their dishonesty. The biggest motivations for dishonesty were the need to get good grades, fear of failing, and lack of understanding of the content and methodology used by professors.
Contributions of the Study: This paper advances the literature and brings contributions on the subject, as it helps to understand academic dishonesty better. Observing the main motivations of students to commit dishonest acts is important for educational institutions and teachers since it helps to understand some motivations that induce students to be academically dishonest. With such knowledge, faculty, and universities can develop and implement policies and methods that encourage fairer procedures, discouraging dishonesty in the academic environment. Consequently, it will improve the quality of teaching and learning and the training of more qualified and honest workers in the professional market.
Una aproximación ecológica al estudio del parasitismo en el "Congrio negro" Genypterus maculatus (TSCHUDI) (PISCES: OPHIDIIDAE)
Authors: George-Nascimento F. Mario , Huet D. Brian 
Published: January 2024

En el examen parasitológico de 80 congrios negros Genyptnus maculatus (Tschudi) recolectados en el puerto de Talcahuano. Chile, se encontró los siguientes taxa: Entre los ectoparásitos, el copépodo lepeophtheirus yañezi y a un hirudíneo de la familia Piscicolidae. Entre los endoparásitos. en el tracto digestivo se encontró al cestodo Auoncocephalus chilensis, el nemátodo Cucullanus sp. y al tremátodo Lecitochirium genypteri; en la caviidad celomática, y al estado larval, se encontró a los cestodos Hepatoxylon trichiuri. Nybehnia sp., un plerocercoide de la familia Diphyllobothridae, a los nematodos Amsakis sp y Phocanema sp.. y al acantocéfalo Corynosoma sp. De la comparación cuali y cuantitativa de las parasitosis del congrio negro y del congrio colorado Genypterus chilensis (Guichenot). se deduce que existiría una segregación trófica entre ambas especies de huéspedes: esto se debe a las diferencias notables en la prevalencia y abundancia de las infecciones por Anisakis sp. y por Corxnosoma sp.. dos parásitos que poseen buenas cualidades como bioindicadores de diferencias dietarias entre sus huéspedes.
Enhancing NPK Uptake and Biomass of Blueberries in Alluvial Clay Soil Using Biochar and Compost
Authors: Ngoc Ngo Phuong , Quynh Le Ngoc , Ly Le Minh , Thao Pham Thi Phuong , Van Dang Le , Em Tran Hoang , Hung Ngo Ngoc 
Published: January 2024

Background:
The Mekong Delta features acidic clay soil of alluvial origin with a soil texture ranging from silty clay to clay. The growth of wild blueberry plants in clay soils requires the addition of materials to enhance soil porosity and aeration.

Objective:
The objective of this study was to examine the effects of the combined use of biochar and compost on the growth, yield, and NPK uptake of blueberry (
Vaccinium tenellum) cultivated in the Mekong Delta.

Methods:
The pot experiment had a 3 × 3 factorial design, containing the application of biochar at 0, 10, and 20 t ha
-1 (B0, B10, and B20, respectively), compost at 0, 5, and 10 t ha
-1 (C0, C5, and C10, respectively), and NPK at 45:20:20 kgha
-1 according to the growth stages of blueberries.

Results:
The interaction between biochar and compost provided a more efficient response in terms of plant growth, yield, and NPK uptake. Notably, in the combined application of B20 and C10, NPK uptake and biomass of blueberries were significantly increased. However, only the concentration (gkg
-1) of N (14.8) and K (3.82), except for P (1.37), in the blueberry leaves were below the Trevett threshold.

Conclusion:
This approach effectively mitigates the challenges posed by high clay content in the soil, which results in poorer soil porosity and aeration. The findings emphasize the potential benefits of tailored soil amendment strategies to optimize blueberry cultivation in similar environments.
Feasibility and Risks of Chili Farming in Disaster-Prone Areas of Mount Merapi, Indonesia
Authors: Rahmawati Nur , Rozaki Zuhud , Al Riyadh Rofiqoh Zuroida , Susanawati Susanawati 
Published: January 2024

Mount Merapi, located in Indonesia, is an active volcano that poses a significant threat to the surrounding communities. Vegetables, including chili, are grown in the disaster-prone areas surrounding Mount Merapi, despite the risks associated with the active volcano. Based on the prevailing wind patterns in the region, the disaster-prone areas surrounding Mount Merapi have been classified into four distinct zones, namely Zones I, II, III, and IV, each characterized by distinct agroecosystems, feasibility, and risk levels. Therefore, this study aimed to describe agroecosystems, costs, income, feasibility, and risks of chili farming in in the four zones surrounding Mount Merapi. The samples of this study consist of 163 farmers from the four disaster-prone zones surrounding Mount Merapi, selected through purposive sampling. The RC ratio was employed as part of the feasibility analysis, and the production and income risks were analyzed. The results showed that chili farming in Zone IV (the area farthest from the disaster center) possessed the lowest cost, revenue, and income. On the contrary, Zone III generated the highest cost and revenue, while Zone I (the area with the highest vulnerability to disasters) had the highest income. The range of R/C values ranges from 2.40 in Zone I to 1.16 in Zone IV. Considering the results, chili farming was feasible in disaster-prone areas, where the production risk was lower than the income risk. Therefore, Zone I, the area with extremely high disaster risk, had the lowest production and income risk. This study highlighted that chili farming provides benefits to the vulnerable farmers and new perspective for agricultural sustainability in the area of Mount Merapi.
Porous Carrageenan-Derived Carbons for Removal of Pb(II) Ions from Aqueous Solution
Authors: Anisuzzaman S M , Mansa Rachel Fran , Elkes Richmond Pillai 
Published: January 2024

Activated carbon (AC) is a widely used adsorbent that can be applied to remove lead (Pb(II)) ions from wastewater. In the current work, carrageenan was used as a precursor to prepare carraggenan based activated carbon (CAC) using potassium hydroxide (KOH) as a chemical activating agent for Pb(II) ions adsorption from aqueous solution of lead nitrate (Pb(NO3)2). The preparation process involved activation of the carrageenan with KOH at a ratio of 1:4 followed by carbonization at 700oC for 4 h. Physical and chemical characterization of synthesized CAC was conducted to understand surface morphology and functional groups. As the scanning electron microscope (SEM) analysis found, the CAC particle sizes are, on average 25.11 µm before adsorption and 39.21 µm after adsorption. Functional group studies proved that the adsorbate had been adsorbed into the CAC by showing a band stretch of the nitrile group in the Fourier transform infrared (FTIR) spectroscopy analysis. The adsorption process was optimized by changing the temperature of adsorption, dosage of adsorbent, and initial concentration of adsorbate. At the optimum conditions, maximum Pb(II) ions adsorption on the CAC was achieved by 99.04%. Throughout this study, the highest capacity of CAC was determined to be 1.95 mg/g, while the minimum capacity was found to be 0.19 mg/g. Langmuir and Freundlich isotherm were studied to understand adsorption mechanisms. The results suggested that the Langmuir isotherm model fits better than the Freundlich model with a regression coefficient of 0.9845. Pseudo-first-order and pseudo-second-order kinetic models were applied to test the experimental data. Pseudo-second-order exhibited the best fit data for kinetic studies with a regression coefficient of 0.9996, indicating that the adsorption of lead using CAC is limited by the chemisorption process.
Sistem Formula dan Fungsi Dalam Tradisi Lisan Hida`a Al-Ibil
Authors: Izdihar Rifdy 
Published: January 2024

Penelitian ini membahas sistem formula dan fungsi-fungsi yang terdapat di dalam salah satu tradisi lisan dari Saudi Arabia, yaitu tradisi lisan Hida`a Al-Ibil. Teori yang digunakan adalah teori formula dari Parry-Lord dan teori fungsi dari Alan Dundes. Objek material yang diteliti adalah dua puluh delapan contoh Hidā`a Al-Ibil terdiri dari tiga belas contoh dari artikel Qasaid Hawabil al-Ibil Ilhaqu aljiblan.net yang ditulis oleh Saud Lami, dua contoh dari artikel Gina al-Ibil al-Huda`a: Fann al-‘Arab al-Aqdam Alladzi Ahabbahu Rasulu al-Islam wa Mārasahu ‘Adadun Min as-Sahābah raseef22.net yang ditulis oleh Ahmad Matārik, dan tiga belas contoh dari artikel Al-Hida`a Al-Harbi Istinhāḍ Li Al-Himam Wa I’tizāz wa Iftikhār Bi Amjād Al-Hāḍir wa Al-Māḍi www.alriyadh.com yang ditulis oleh Abdurrahim Al-Ahmadi. Hasil penelitian berupa adanya dua tipe formula di dalam tradisi lisan Hida`a Al-Ibil, yaitu berupa pengulangan kata-kata serta penggunaan nama-nama daerah di sekitar Saudi Arabia. Hasil penelitian juga berupa adanya fungsi-fungsi dari tradisi lisan Hida`a Al-Ibil yang diperuntukkan untuk masyarakat Badui Saudi Arabia. Kelima fungsi Hida`a Al-Ibil yaitu fungsi membantu pendidikan anak muda, meningkatkan perasaan solidaritas kelompok, memberi sanksi sosial agar masyarakat berperilaku baik atau memberi hukuman, sebagai sarana kritik sosial, memberikan suatu pelarian yang menyenangkan dari kenyataan, dan mengubah pekerjaan yang membosankan menjadi permainan
AN ASSESSMENT OF THE RELATIVE ANTIOXIDANT ACTIVITY OF BARK EXTRACTS OF ACACIA CATECHU BY IN VITRO FREE RADICAL SCAVENGING ANALYSIS
Authors: TIWARI ARCHANA , TIWARI AVINASH 
Published: January 2024

Objective: The objective of this research was to examine and compare the capacity of several bark extracts of Acacia catechu to scavenge nitric oxide (NO) free radicals. The study also examined the evaluation of variations in concentration that are reliant on both concentration levels and seasonal changes, using samples obtained throughout various seasons over a span of two consecutive years.
Methods: In this study, six extracts were made utilizing solvents, including ethanol, methanol, aqueous solution, acetone, chloroform, and benzene. In the in vitro investigation, a nitric oxide (NO) assay was conducted to evaluate the free radical scavenging efficacy of the test samples.
Results: Out of seven tested sample concentrations, 15.25 µg/ml was reported to be ineffective; higher than 500 µg/ml concentrations (i.e., 705 and 1000) were observed to be less effective than their lower concentrations, while 31.5–500 µg/ml drug concentrations were observed to be protective. Among these three, 125 µg/ml concentrations were found to be most effective (p<0.01 or more). In solvent-based results, methanolic, ethanolic, aqueous, and acetone extracts exhibited at least p<0.01 significant effective NO scavenging, but acetone extract was seen to have comparatively less protection (p<0.05) than the other three extracts. Chloroform and benzene extracts, respectively, showed less protection. Samples collected in the summer season showed greater protection than winter and Manson.
Conclusion: This study provided a clear observation of the impact of extraction solvent, concentration of drug, and season of sample collection on in vitro free radical scavenging potential. These data could help provide possible applications for regional plants for medicinal purposes.
Advantages and Disadvantages of Globalization of the English Language for Ukrainian People
Authors: Makarenko Mariia , Sydorenko Arina , Shpak Oleksii , Pivnenko Volodymyr 
Published: December 2023

Abstract
Since English is primarily the medium of communication for international business and trade. In addition to being the official language of many international organizations (such as the UN, WHO, etc.), it has become a lingua franca in the modern world. English language lessons are delivered and required in many secondary schools globally. English is taught by many public schools as a compulsory subject, sometimes at the expense of other languages. Taking into account the rapid global spread of the English language, the article examines the main advantages and disadvantages of English being a global language providing an example of Ukrainians living abroad and in their home country. Postcolonial and globalization theories are analyzed to demonstrate that the spread of English is a result of the British Empire and the rise of the United States as a global actor in international relations thereafter. On the contrary, the linguistic human capital theory and theory of cultural capital underline that language proficiency may serve either as a limitation or a getaway in socioeconomic situations. The article deploys a qualitative research method, namely, online surveys of Ukrainians in Poland, Estonia, Germany, Spain, and Ukraine. The results indicate that English as a global language provokes inequalities for Ukrainians whose English skills are even below pre-intermediate level, both within Ukraine and outside their home country. The driving motivation for both groups to learn English is better job opportunities.
RECONSTRUCTION OF NUSYÚZ CONCEPT IN COMPILATION OF ISLAMIC LAW IN INDONESIA (Gender Equality Perspective Analysis)
Authors: Fitri Al , Alamsyah A. , Sadari S. , Susanto Is 
Published: January 2024

Nusyúz is a classical conception codified as a standard law written in Qs. an-Nisáa’ verses 34 and 128. The conventional fiqh perspective of nusyúz connotes the wife’s disobedience to her husband, because it is influenced by the patriarchy of pre-Islamic Arab culture. Presidential Instruction Number 1 of 1991 concerning the Compilation of Islamic Law in Indonesia mentions nusyúz in Articles 80, 84 and 125, only regulates the wife’s nusyúz and its legal sanctions, while the husband’s nusyúz is not mentioned. There is ambivalence, ambiguity and legal injustice for the wife. The focus of this research is the concept of nusyúz in KHI from a gender perspective and its correlation with the development of family law in Indonesia. This type of research is library research with a gender equality analysis approach. The results of this study indicate that it is necessary to rearrange the concept of nusyúz in the KHI, including the modern era understanding of nusyúz and adding the husband's concept of nusyúz and its legal sanctions in KHI.Keywords: Nusyúz Modern Era, Gender Perspective, Justice.