bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Correlates of Biological Aging and the Influence on Prediction of Mortality
Authors: Akeju Oluwasefunmi , Mens Michelle M J , Warmerdam Robert , Dijkema Marjolein , van den Biggelaar Anita H J , Franke Lude , Goudsmit Jaap , Wu Julia W 
Published: February 2024

Abstract
Longevity and disease-free survival are influenced by a combination of genetics and lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may outperform chronological age in predicting health and longevity. This study investigated the relationship between genetic risks, lifestyle factors, and delta age (Δage), estimated as the difference between biological and chronological age. BioAge and Δage were calculated for 52 418 participants from the population-based Lifelines cohort. We computed 2 independent polygenic risk scores (PRS) for health span and DNA methylation-based aging clock to characterize genetic risks. The capacity of BioAge to predict all-cause mortality when adjusted for chronological age and genetic risks for aging, was assessed. Obesity, lifestyle, socioeconomic status, sex, and genetic variations in a population contributed to the differences in the rates of accelerated aging. The overall risk of death for a 1-year increase in BioAge for a given chronological age and sex among the genotyped participants was 11% (HR = 1.11; 95% CI: 1.09, 1.13). After adjusting for genetic factors, BioAge maintained its sensitivity for predicting mortality. Findings from this study ascertain that BioAge can be a useful tool for risk stratification in research and aging interventions.
Is Multidimensional Poverty Associated to Dementia Risk? The Case of Older Adults in Pakistan
Authors: Trani Jean-François , Zhu Yiqi , Park Soobin , Babulal Ganesh M 
Published: February 2024

Abstract

Background and Objectives
Multidimensional poverty is associated with dementia. We aimed at establishing this association in Pakistan.

Research Design and Methods
A cross-sectional study was conducted in Punjab and Sindh, Pakistan, between March 30, 2002, and August 22, 2022, among adults aged 50 and older. Multidimensional poverty measures were composed of 6 dimensions and 15 indicators. Poverty was compared between adults with and without dementia using the Rowland Universal Dementia Assessment Scale, adjusting for sex, age, marital status, and household size. Associations between dementia and poverty were investigated using a multivariate logistic regression model.

Results
We found that 594 (72.7%), 171 (20.9%), and 52 (6.4%) had no, mild, and moderate-to-severe dementia, respectively. More women than men had dementia (11.4% vs 2.9%). Approximately 40.4% of adults with dementia were found to be deprived in 4 or more dimensions compared to 8.9% without dementia, and the difference in multidimensional poverty between them was 348.6%. Education, health, living conditions, and psychological well-being were the main contributors to poverty. Poverty in 4 or more dimensions was strongly associated with dementia (odds ratio [OR], 5.02; 95% confidence interval [CI], 2.07–12.16) after adjusting for sex, marital status, age, and household size, with greater odds for older women (OR, 2.02; 95% CI, 1.41–2.90).

Discussion and Implications
Our findings suggest that early improvement in social determinants of health through targeted structural policies may prevent dementia later in life. Improving access to free, quality education, health care including mental health care and basic living standards, and employment should reduce the collective risk of dementia.
Consent to Labour Exploitation
Authors: Niezna Maayan 
Published: February 2024

Abstract
This article argues there is no one-size-fits-all approach to the role of consent to labour exploitation. However, there is significant value in considering the theoretical underpinnings of different legal interventions addressing labour exploitation. The article first explores different theoretical accounts of exploitation in political philosophy: emphasising taking unfair advantage, violation of dignity or coercion. Following the theoretical analysis, the article maps the different legal interventions in labour law, criminal law and public law. It suggests that the starting point of analysing consent to labour exploitation—fairness, dignity, individual coercion, structural coercion and consent—determines the result of the analysis. This section demonstrates the connection between different areas of law and different theoretical approaches to the role of consent to labour exploitation. The different approaches are then applied to examples based on real-world cases. The article concludes that in the context of labour exploitation, consent is a necessary but insufficient condition for the legitimacy and legality of the labour relations. The fairness of the result and protecting workers’ dignity should also be considered.
Enrichment of putative plant growth promoting microorganisms in biodynamic compared with organic agriculture soils
Authors: Milke Felix , Rodas-Gaitan Heberto , Meissner Georg , Masson Vincent , Oltmanns Meike , Möller Morten , Wohlfahrt Yvette , Kulig Boris , Acedo Alberto , Athmann Miriam , Fritz Jürgen 
Published: February 2024

Abstract
The potential of soils to maintain biological productivity, defined as soil health, is strongly influenced by human activity, such as agriculture. Therefore, soil management has always been a concern for sustainable agriculture and new methods that account for both soil health and crop yield must be found. Biofertilization using microbial inoculants emerges as a promising alternative to conventional interventions such as excessive mineral fertilization and herbicide use. Biodynamic preparations used as a central part of biodynamic agriculture have various effects on soil properties, such as microbial biomass and respiration. We conducted several biomarker experiments to infer the effect of biodynamic preparations on soil prokaryotic and fungal communities and compared results to organic management. Potential plant growth promoting amplicon sequence variants were quantified using a commercial database based on their taxonomic identity. We found significantly higher numbers of putative plant growth promoting amplicon sequence variants in biodynamically compared with organically treated soils. Furthermore, prokaryotic amplicon sequence variants enriched in biodynamic preparations were found in higher numbers in biodynamically treated soils, indicating successful colonization after treatment. Experiments were conducted at three locations in Germany and 21 locations in France covering different crops and soil types. Altogether, our results indicate that biodynamic preparations can act as biofertilizers that promote soil health by increasing the abundance of plant growth promoting microorganisms.
Public perspectives on the use of different data types for prediction in healthcare
Authors: Nong Paige , Adler-Milstein Julia , Kardia Sharon , Platt Jodyn 
Published: February 2024

Abstract

Objective
Understand public comfort with the use of different data types for predictive models

Materials and Methods
We analyzed data from a national survey of US adults (n = 1436) fielded from November to December 2021. For three categories of data (identified using factor analysis), we use descriptive statistics to capture comfort level.

Results
Public comfort with data use for prediction is low. For 13 of 15 data types, most respondents were uncomfortable with that data being used for prediction. In factor analysis, 15 types of data grouped into three categories based on public comfort: (1) personal characteristic data, (2) health-related data, and (3) sensitive data. Mean comfort was highest for health-related data (2.45, SD 0.84, range 1-4), followed by personal characteristic data (2.36, SD 0.94), and sensitive data (1.88, SD 0.77). Across these categories, we observe a statistically significant positive relationship between trust in health systems’ use of patient information and comfort with data use for prediction.

Discussion
Although public trust is recognized as important for the sustainable expansion of predictive tools, current policy does not reflect public concerns. Low comfort with data use for prediction should be addressed in order to prevent potential negative impacts on trust in healthcare.

Conclusion
Our results provide empirical evidence on public perspectives, which are important for shaping the use of predictive models. Findings demonstrate a need for realignment of policy around the sensitivity of non-clinical data categories.
Homo-trimeric structure of the ribonuclease for rRNA processing, FAU-1, from Pyrococcus furiosus
Authors: Kawai Gota , Okada Kiyoshi , Baba Seiki , Sato Asako , Sakamoto Taiichi , Kanai Akio 
Published: February 2024

Abstract
Crystal structure of a ribonuclease for ribosomal RNA processing, FAU-1, from Pyrococcus furiosus was determined with the resolution of 2.57 Å in a homo-trimeric form. The monomer structure consists of two domains: N-terminal and C-terminal domains. C-terminal domain forms trimer and each N-terminal domain locates outside of the trimer core. In the obtained crystal, a dinucleotide, pApUp, was bound to the N-terminal domain, indicating that N-terminal domain has the RNA-binding ability. The affinities to RNA of FAU-1 and a fragment corresponding to the N-terminal domain, FAU-ΔC, were confirmed by polyacrylamide gel electrophoresis and nuclear magnetic resonance (NMR). Interestingly, well-dispersed NMR signals were observed at 318K, indicating that the FAU-ΔC–F18 complex form an ordered structure at higher temperature. As predicted in our previous works, FAU-1 and ribonuclease (RNase) E show a structural similarity in their RNA-binding regions. However, structural similarity between RNase E and FAU-1 could be found in the limited regions of the N-terminal domain. On the other hand, structural similarity between C-terminal domain and some proteins including a phosphatase was found. Thus, it is possible that the catalytic site is located in C-terminal domain.
Uncovering gender stereotypes in controversial science discourse: evidence from computational text and visual analyses across digital platforms
Authors: Chen Kaiping , Duan Zening , Kim Sang Jung 
Published: February 2024

Abstract
This study examines how gender stereotypes are reflected in discourses around controversial science issues across two platforms, YouTube and TikTok. Utilizing the Social Identity Model of Deindividuation Effects, we developed hypotheses and research questions about how content creators might use gender-related stereotypes to engage audiences. Our analyses of climate change and vaccination videos, considering various modalities such as captions and thumbnails, revealed that themes related to children and health often appeared in videos mentioning women, while science misinformation was more common in videos mentioning men. We observed cross-platform differences in portraying gender stereotypes. YouTube’s video descriptions often highlighted women-associated moral language, whereas TikTok emphasized men-associated moral language. YouTube’s thumbnails frequently featured climate activists or women with nature, while TikTok’s thumbnails showed women in Vlog-style selfies and with feminine gestures. These findings advance understanding about gender and science through a cross-platform, multi-modal approach and offer potential intervention strategies.
Levonorgestrel-releasing intrauterine device therapy vs oral progestin treatment for reproductive-aged patients with endometrial intraepithelial neoplasia: a systematic review and meta-analysis
Authors: Suzuki Yukio , Ferris Jennifer S , Chen Ling , Dioun Shayan , Usseglio John , Matsuo Koji , Xu Xiao , Hershman Dawn L , Wright Jason D 
Published: February 2024

Abstract

Background
We conducted a systematic review and meta-analysis to examine outcomes of patients with endometrial intraepithelial neoplasia treated with oral progestins or a levonorgestrel-releasing intrauterine device (IUD).

Methods
We conducted a systematic review across 5 databases to examine outcomes of progestational treatment (oral progestins or levonorgestrel-releasing IUD) for patients with endometrial intraepithelial neoplasia. The primary outcome was the best complete response rate within 12 months of primary progestational treatment. Sensitivity analyses were performed by removing studies with extreme effect sizes. Secondary outcomes included the pooled pregnancy rate.

Results
We identified 21 eligible studies, including 824 premenopausal patients with endometrial intraepithelial neoplasia, for our meta-analysis. Among these, 459 patients received oral progestin, and 365 patients received levonorgestrel-releasing IUD as a primary progestational treatment. The pooled best complete response proportion within 12 months was 82% (95% confidence interval [CI] = 69% to 91%) following oral progestin treatment and 95% (95% CI = 81% to 99%) following levonorgestrel-releasing IUD treatment. After removing outlier studies, the pooled proportion was 86% (95% CI = 75% to 92%) for the oral progestin group and 96% (95% CI = 91% to 99%) for the levonorgestrel-releasing IUD group, with reduced heterogeneity. The pooled pregnancy rate was 50% (95% CI = 35% to 65%) after oral progestin and 35% (95% CI = 23% to 49%) after levonorgestrel-releasing IUD treatment.

Conclusions
This meta-analysis provides data on the effectiveness of oral progestins and levonorgestrel-releasing IUD treatment within 12 months of treatment among premenopausal patients with endometrial intraepithelial neoplasia. Although based on small numbers, the rate of pregnancy after treatment is modest. These data may be beneficial for selecting progestational therapies that allow fertility preservation for patients with endometrial intraepithelial neoplasia.
Bayesian semi-parametric inference for clustered recurrent events with zero inflation and a terminal event
Authors: Tian Xinyuan , Ciarleglio Maria , Cai Jiachen , Greene Erich J , Esserman Denise , Li Fan , Zhao Yize 
Published: February 2024

Abstract
Recurrent events are common in clinical studies and are often subject to terminal events. In pragmatic trials, participants are often nested in clinics and can be susceptible or structurally unsusceptible to the recurrent events. We develop a Bayesian shared random effects model to accommodate this complex data structure. To achieve robustness, we consider the Dirichlet processes to model the residual of the accelerated failure time model for the survival process as well as the cluster-specific shared frailty distribution, along with an efficient sampling algorithm for posterior inference. Our method is applied to a recent cluster randomized trial on fall injury prevention.
ggPlantmap: an open-source R package for the creation of informative and quantitative ggplot maps derived from plant images
Authors: Jo Leonardo , Kajala Kaisa 
Published: February 2024

Abstract
As plant research generates an ever-growing volume of spatial quantitative data, the need for decentralized and user-friendly visualization tools to explore large and complex datasets becomes crucial. Existing resources, such as the Plant eFP (electronic Fluorescent Pictograph) viewer, have played a pivotal role on the communication of gene expression data across many plant species. However, although widely used by the plant research community, the Plant eFP viewer lacks open and user-friendly tools for the creation of customized expression maps independently. Plant biologists with less coding experience can often encounter challenges when attempting to explore ways to communicate their own spatial quantitative data. We present ‘ggPlantmap’ an open-source R package designed to address this challenge by providing an easy and user-friendly method for the creation of ggplot representative maps from plant images. ggPlantmap is built in R, one of the most used languages in biology, to empower plant scientists to create and customize eFP-like viewers tailored to their experimental data. Here, we provide an overview of the package and tutorials that are accessible even to users with minimal R programming experience. We hope that ggPlantmap can assist the plant science community, fostering innovation, and improving our understanding of plant development and function.
How Do I Keep Myself Calm?
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter covers Session 8 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. In this session the group participants continue thinking of tools that they can use to cope with anger. The chapter focuses on the specific coping mechanism of self-talk, which can have an impact on a person’s feelings and reactions to certain situations. The movie clip shown in this session will help the girls to relate to and understand the self-talk concept. The session activities include self-talk role-playing and real-life role-playing. The materials, scripts, and sequences that the facilitators will need for the activities are provided.
Communication
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter covers Session 10 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. In this session the group participants learn about the importance of communication. This chapter provides the materials, preparations, and script to help the facilitators teach the girls about effectively communicating their feelings when they are upset. The session’s overall goal is for the participants to learn how to talk through a difficult situation without harming the relationship. The chapter introduces the concept of active listening, and the session activities teach participants how to effectively listen to another person by maintaining eye contact, nodding, and rephrasing what the other person has said. The “I” statements exercise helps the girls become more aware of their thoughts, feelings, and intentions and how best to express them.
Repairing Damaged Relationships
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter covers Session 13 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. This session focuses on the ways that group participants can repair damaged relationships. Many of the girls in the group are likely to have a history of reacting to anger in ways they regret, which results in damaged relationships with friends and family. Facilitators teach the girls effective ways to apologize and ask for forgiveness from others. In a role-play, the facilitators depict an ineffective way to apologize and then ask the girls to identify why it wasn’t an effective apology. A letter-writing activity is presented so the girls can practice apologizing as a way of repairing a damaged relationship.
Does Everyone See the Same Thing?
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter provides the facilitator materials needed for Session 4 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. This session primarily involves learning about how people have different perspectives. The session’s catch phrase is “Instead of thinking of the worst, seek other explanations first.” In line with their goal sheet’s task of seeing how their thoughts can affect their reactions, the participants will write down their thoughts and reactions to two different situations when they feel sad, upset, or angry. The chapter also provides figures and exercises needed for the session. The girls are expected to talk about their feelings, thoughts, and reactions to a situation to see how they are connected and to stay out of trouble.
Triggers of Anger
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter contains the facilitator materials needed for Session 6 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. This session revolves around triggers of anger. The facilitators will teach the girls how people, places, and things can trigger anger and will encourage the girls to identify the triggers in their lives. The Session 6 catch phrase is “When a match gets lit, slow down, don’t have a fit.” The goal sheet aims to teach the participants to avoid their triggers and to refrain from acting on their anger. The chapter lists the movie clips for the session, which feature conflicts or arguments to help the girls identify triggers. It also provides the figures needed for the session activities, such as creating individual matchbooks of triggers and making a catch phrase sign.
Self-Control
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter provides the facilitator materials for Session 7 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. This session teaches the participants about the different tools they can use to keep their temper at bay. Because it is difficult to remain calm when feeling tested and angry, the facilitators encourage the participants to use and practice different tools when they are angry to see which would work best for them. The Session 7 catch phrase is “Use your tools so you don’t break rules.” Materials are provided for the session activities, such as the taunt list for the “Ugly Bag” activity and the taunt list for the cards and memory game. Also provided are the materials that the facilitators will need to teach about the toolbox and tools and to create a catch phrase sign.
Identifying Options and Consequences
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter provides the facilitator materials for Session 12 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. This session focuses on the options and consequences of participants’ actions and reactions. The facilitators teach the girls about the different tools they can use to handle difficult situations. The participants learn to choose the best tool for dealing with their anger by weighing the advantages and disadvantages of each one. The girls are urged to think about the prices and rewards for different reactions when they get angry or upset. The Session 12 catch phrase is “When you’re angry, don’t get lost—think of options and their cost.” The goal sheet’s aim is to help the girls figure out the best reaction to certain situations.
Can I Be a Star?
Authors: Goldstein Naomi E. S. , Serico Jennifer M. , Haney-Caron Emily , Giallella Christy L. , Kalbeitzer Rachel , Zelechoski Amanda D. , Riggs Romaine Christina L. , Kemp Kathleen 
Published: February 2024

Abstract
This chapter provides the facilitator materials for Session 15 of the Juvenile Justice Anger Management (JJAM) Treatment for Girls. In this session the participants plan a play that they will perform in the next session. The play will allow the girls to showcase what they have learned and practiced in a creative way. The participants will need to find a good time to practice their lines and prepare for the play. The Session 15 catch phrase is “I’ve come so far, now I’ll be a star!” The goal sheet focuses on learning the lines for the play. The chapter also includes an invitation for the facility staff to attend the play.