bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hollow Carbon and MXene Dual‐Reinforced MoS2 with Enlarged Interlayers for High‐Rate and High‐Capacity Sodium Storage Systems
Authors: Pan Hanqing , Huang Yan , Cen Xinnuo , Zhang Ming , Hou Jianhua , Wu Chao , Dou Yuhai , Sun Bing , Wang Ying , Zhang Binwei , Zhang Lei 
Published: January 2024

AbstractSodium‐ion batteries (SIBs) and sodium‐ion capacitors (SICs) are promising candidates for cost‐effective and large‐scale energy storage devices. However, sluggish kinetics and low capacity of traditional anode materials inhibit their practical applications. Herein, a novel design featuring a layer‐expanded MoS2 is presented that dual‐reinforced by hollow N, P‐codoped carbon as the inner supporter and surface groups abundant MXene as the outer supporter, resulting in a cross‐linked robust composite (NPC@MoS2/MXene). The hollow N, P‐codoped carbon effectively prevents agglomeration of MoS2 layers and facilitates shorter distances between the electrolyte and electrode. The conductive MXene outer surface envelops the NPC@MoS2 units inside, creating interconnected channels that enable efficient charge transfer and diffusion, ensuring rapid kinetics and enhanced electrode utilization. It exhibits a high reversible capacity of 453 mAh g−1, remarkable cycling stability, and exceptional rate capability with 54% capacity retention when the current density increases from 100 to 5000 mA g−1 toward SIBs. The kinetic mechanism studies reveal that the NPC@MoS2/MXene demonstrates a pseudocapacitance dominated hybrid sodiation/desodiation process. Coupled with active carbon (AC), the NPC@MoS2/MXene//AC SICs achieve both high energy density of 136 Wh kg−1 at 254 W kg−1 and high‐power density of 5940 W kg−1 at 27 Wh g−1, maintaining excellent stability.
Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death
Authors: Zhao Yu‐Qiang , Yu Le , Zhang Lanyun , Liu Huan , Zhou Ying , Kim Jong Seung 
Published: January 2024

AbstractThe induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) therapeutic agents generate reactive oxygen species through photo/ultrasound activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting in the death of tumor cells. The presented comprehensive review delves into recent advancements in AIE therapeutic agents designed to trigger RCD or synergize with RCD inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic cell death, autophagy, ferroptosis, and cuproptosis. Additionally, the intricate regulatory mechanisms through which activatory‐AIE therapeutics influence distinct RCD pathways are examined. A forward‐looking perspective on future developments and pertinent challenges within this exciting realm is presented, anticipating the continued evolution of activatable AIE therapeutics as a transformative approach to enhance tumor therapy.
Interstitial pulmonary disease and aluminum trihydrate exposure: A single case report and detailed workplace analysis
Authors: Corwin Claudia , Waterhouse Hillary , Abraham Jerrold L. , Sanyal Soma , Crawford Judith A. , Caddell Matthew , Hodgson Michael J. 
Published: January 2024

AbstractExposure to aluminum compounds is clearly associated with pulmonary function decrements, and several animal models document possible mechanisms of aluminum‐ compound‐induced pulmonary toxicity. Nevertheless, disagreements remain about the precise mechanism by which exposures lead to damage. We present a strong case for attributing a case of interstitial pulmonary disease to occupational exposure to aluminum trihydrate. This report follows a 2014 publication of another case of interstitial pulmonary disease following a similar exposure. Our patient eventually underwent double lung transplantation nearly 5 years postexposure. Detailed pulmonary particulate elemental analysis suggested that aluminum metal, including aluminum trihydrate, was the most likely cause. A detailed assessment of the worker's relevant occupational exposures accompanies this case report.
Flexible grouping patterns in a western and eastern chimpanzee community
Authors: Koops Kathelijne , Akankwasa Walter , Camara Henry Didier , Fitzgerald Maegan , Keir Alex , Mamy Gnan , Matsuzawa Tetsuro , Péter Hella , Vicent Kizza , Zuberbühler Klaus , Hobaiter Catherine 
Published: January 2024

AbstractPrimate social organizations, or grouping patterns, vary significantly across species. Behavioral strategies that allow for flexibility in grouping patterns offer a means to reduce the costs of group living. Chimpanzees (Pan troglodytes) have a fission‐fusion social system in which temporary subgroups (“parties”) change in composition because of local socio‐ecological conditions. Notably, western chimpanzees (P. t. verus) are described as showing a higher degree of bisexual bonding and association than eastern chimpanzees, and eastern female chimpanzees (P. t. schweinfurthii) are thought to be more solitary than western female chimpanzees. However, reported comparisons in sociality currently depend on a small number of study groups, particularly in western chimpanzees, and variation in methods. The inclusion of additional communities and direct comparison using the same methods are essential to assess whether reported subspecies differences in sociality hold in this behaviorally heterogeneous species. We explored whether sociality differs between two communities of chimpanzees using the same motion‐triggered camera technology and definitions of social measures. We compare party size and composition (party type, sex ratio) between the western Gahtoy community in the Nimba Mountains (Guinea) and the eastern Waibira community in the Budongo Forest (Uganda). Once potential competition for resources such as food and mating opportunities were controlled for, subspecies did not substantially influence the number of individuals in a party. We found a higher sex‐ratio, indicating more males in a party, in Waibira; this pattern was driven by a greater likelihood in Gahtoy to be in all‐female parties. This finding is the opposite of what was expected for eastern chimpanzees, where female‐only parties are predicted to be more common. Our results highlight the flexibility in chimpanzee sociality, and caution against subspecies level generalizations.
Aurora B facilitates cholangiocarcinoma progression by stabilizing c‐Myc
Authors: Liu Ke , Zhou Xuxuan , Huang Fei , Liu Lihao , Xu Zijian , Gao Chongqing , Zhang Keke , Hong Jian , Yao Nan , Cheng Guohua 
Published: January 2024

AbstractBackgroundCholangiocarcinoma (CCA), a malignancy that arises from biliary epithelial cells, has a dismal prognosis, and few targeted therapies are available. Aurora B, a key mitotic regulator, has been reported to be involved in the progression of various tumors, yet its role in CCA is still unclarified.MethodsHuman CCA tissues and murine spontaneous CCA models were used to assess Aurora B expression in CCA. A loss‐of‐function model was constructed in CCA cells to determine the role of Aurora B in CCA progression. Subcutaneous and liver orthotopic xenograft models were used to assess the therapeutic potential of Aurora B inhibitors in CCA.ResultsIn murine spontaneous CCA models, Aurora B was significantly upregulated. Elevated Aurora B expression was also observed in 62.3% of human specimens in our validation cohort (143 CCA specimens), and high Aurora B expression was positively correlated with pathological parameters of tumors and poor survival. Knockdown of Aurora B by siRNA and heteroduplex oligonucleotide (HDO) or an Aurora B kinase inhibitor (AZD1152) significantly suppressed CCA progression via G2/M arrest induction. An interaction between Aurora B and c‐Myc was found in CCA cells. Targeting Aurora B significantly reduced this interaction and accelerated the proteasomal degradation of c‐Myc, suggesting that Aurora B promoted the malignant properties of CCA by stabilizing c‐Myc. Furthermore, sequential application of AZD1152 or Aurora B HDO drastically improved the efficacy of gemcitabine in CCA.ConclusionsAurora B plays an essential role in CCA progression by modulating c‐Myc stability and represents a new target for treatment and chemosensitization in CCA.
Cobalt‐Catalyzed Enantioselective Reductive α‐Chloro‐Carbonyl Addition of Ketimine to Construct the β‐Tertiary Amino Acid Analogues
Authors: Xia Tingting , Wu Wenwen , Wu Xianqing , Qu Jingping , Chen Yifeng 
Published: January 2024

Abstractβ‐Tertiary amino acid derivatives constitute one of the most frequently occurring units in natural products and bioactive molecules. However, the efficient asymmetric synthesis of this motif still remains a significant challenge. Herein, we disclose a cobalt‐catalyzed enantioselective reductive addition reaction of ketimine using α‐chloro carbonyl compound as a radical precursor, providing expedient access to a diverse array of enantioenriched β‐quaternary amino acid analogues. This protocol exhibits outstanding enantioselectivity and broad substrate scope with excellent functional group tolerance. Preliminary mechanism studies rule out the possibility of Reformatsky‐type addition and confirm the involvement of radical species in stereoselective addition process. The synthetic utility has been demonstrated through the rapid assembly of iterative amino acid units and oligopeptide, showcasing its versatile platform for late‐stage modification of drug candidates.
Acrylate composite polyurethane binder for steel bridge deck pavements: Process optimization by response surface methodology and microanalysis
Authors: Duan Shaochan , Hu Jianying , Cui Jingxian , Chen Yan , Ma Tao , Wu Xiaonan 
Published: January 2024

AbstractTo better serve the steel bridge deck paving project, a novel room‐temperature curing acrylate composite polyurethane binder (APUB) was developed as a substitute for traditional asphalt binders. APUB was synthesized by the copolymerization of a custom‐made polyurethane prepolymer (BDO‐PU) and acrylate. Fourier transformed infrared and proton nuclear magnetic resonance spectroscopy analyses confirmed the presence of carbamate structures in prepolymer BDO‐PU. Utilizing tensile strength, breaking elongation and water absorption as optimization criteria, the response surface methodology was used to optimize synthesis process of APUB. The results showed that the optimized parameters for APUB synthesis include an isocyanate index (R) of 1.5, a mass ratio of methyl methacrylate to BDO‐PU of 1.1, and a curing agent content of 2.7%. These settings resulted in predicted values of 10.12 MPa for tensile strength, 123.85% for breaking elongation, and 0.075% for water absorption. Experimental validation demonstrated the consistency between the predicted and actual properties of APUB. Further microanalyses, including dynamic mechanical thermal analysis, differential scanning calorimetry, and scanning electron microscope, confirmed APUB exhibits excellent component compatibility and glass transition temperatures suitable for bridge engineering environments. Overall, APUB demonstrates outstanding tensile properties, water resistance, low energy consumption, and potential applications in the steel bridge deck pavement industry.
The postcranial skeleton of Teyujagua paradoxa (Reptilia: Archosauromorpha) from the early Triassic of South America
Authors: De‐Oliveira Tiane M. , Da Silva João Lucas , Kerber Leonardo , Pinheiro Felipe L. 
Published: January 2024

AbstractTeyujagua paradoxa is a remarkable early archosauromorph from the Lower Triassic Sanga do Cabral Formation, Brazil. The species was originally described from an almost complete skull and a few associated cervical vertebrae, and no further postcranial elements were known at that time. Additional fieldwork in the Sanga do Cabral Formation, however, was successful in recovering a fairly complete postcranial skeleton attributable to the holotype. Here, we describe this new postcranial material, which is composed of cervical, dorsal, sacral and caudal vertebrae, limbs, pectoral and pelvic girdles, ribs, and gastralia. The description of its postcranial skeleton makes T. paradoxa one of the best‐known early‐diverging archosauromorphs. The cladistic analysis performed after the scoring of postcranial data recovered T. paradoxa in the same position initially described, close to the node that defines the Archosauriformes. Teyujagua paradoxa shares morphological features with representatives of early‐diverging archosauromorphs and archosauriforms, with certain traits demonstrating a mosaic of plesiomorphic and apomorphic character states. We also performed partitioned morphospace and disparity analysis to elucidate the morphological disparity and evolutionary patterns among archosauromorphs. Teyujagua paradoxa occupies a notable position, suggesting an intermediate morphology between early archosauromorphs and proterosuchids. Disparity estimates highlighted Pseudosuchia and Avemetatarsalia as having the highest median disparity, reflecting their diverse cranial and postcranial morphologies, respectively. These findings offer valuable insights into archosauromorph macroevolution and adaptation.
Biaryl carboxamide‐based peptidomimetics analogs as potential pancreatic lipase inhibitors for treating obesity
Authors: Pandey Vikash , Adhikrao Patil A. , Motiram Gudle M. , Yadav Nisha , Jagtap Utkarsh , Kumar Gautam , Paul Atish 
Published: January 2024

AbstractA series of 1,1′‐biphenyl‐3‐carboxamide and furan‐phenyl‐carboxamide analogs were synthesized using an optimized scheme and confirmed by 1H and 13C nuclear magnetic resonance and high‐resolution mass spectrometry techniques. The synthesized peptidomimetics analogs were screened in vitro to understand the inhibitory potential of pancreatic lipase (PL). Analogs were assessed for the PL inhibitory activity based on interactions, geometric complementarity, and docking score. Among the synthesized analogs, 9, 29, and 24 were found to have the most potent PL inhibitory activity with IC50 values of 3.87, 4.95, and 5.34 µM, respectively, compared to that of the standard drug, that is, orlistat, which inhibits PL with an IC50 value of 0.99 µM. The most potent analog, 9, exhibited a competitive‐type inhibition with an inhibition constant (Ki) of 2.72 µM. In silico molecular docking of analog 9 with the PL (PDB ID:1LPB) showed a docking score of −11.00 kcal/mol. Analog 9 formed crucial hydrogen bond interaction with Ser152, His263, π–cation interaction with Asp79, Arg256, and π–π stacking with Phe77, Tyr114 at the protein's active site. The molecular dynamic simulation confirmed that analog 9 forms stable interactions with PL at the end of 200 ns with root mean square deviation values of 2.5 and 6 Å. No toxicity was observed for analog 9 (concentration range of 1–20 µM) when tested by MTT assay in RAW 264.7 cells.
Indole clubbed 2,4‐thiazolidinedione linked 1,2,3‐triazole as a potent antimalarial and antibacterial agent against drug‐resistant strain and molecular modeling studies
Authors: Upadhyay Dipti B. , Mokariya Jaydeep A. , Patel Paras J. , Patel Subham G. , Das Anwesha , Nandi Arijit , Nogales Joaquina , More Nachiket , Kumar Amit , Rajani Dhanji P. , Narayan Mahesh , Kumar Jyotish , Banerjee Sourav , Sahoo Suban K. , Patel Hitendra M. 
Published: January 2024

AbstractIn the face of escalating challenges of microbial resistance strains, this study describes the design and synthesis of 5‐({1‐[(1H‐1,2,3‐triazol‐4‐yl)methyl]‐1H‐indol‐3‐yl}methylene)thiazolidine‐2,4‐dione derivatives, which have demonstrated significant antimicrobial properties. Compared with the minimum inhibitory concentrations (MIC) values of ciprofloxacin on the respective strains, compounds 5a, 5d, 5g, 5l, and 5m exhibited potent antibacterial activity with MIC values ranging from 16 to 25 µM. Almost all the synthesized compounds showed lower MIC compared to standards against vancomycin‐resistant enterococcus and methicillin‐resistant Staphylococcus aureus strains. Additionally, the majority of the synthesized compounds demonstrated remarkable antifungal activity, against Candida albicans and Aspergillus niger, as compared to nystatin, griseofulvin, and fluconazole. Furthermore, the majority of compounds exhibited notable inhibitory effects against the Plasmodium falciparum strain, having IC50 values ranging from 1.31 to 2.79 μM as compared to standard quinine (2.71 μM). Cytotoxicity evaluation of compounds 5a–q on SHSY‐5Y cells at up to 100 μg/mL showed no adverse effects. Comparison with control groups highlights their noncytotoxic characteristics. Molecular docking confirmed compound binding to target active sites, with stable protein–ligand complexes displaying drug‐like molecules. Molecular dynamics simulations revealed dynamic stability and interactions. Rigorous tests and molecular modeling unveil the effectiveness of the compounds against drug‐resistant microbes, providing hope for new antimicrobial compounds with potential safety.
A near‐infrared fluorescent probe for detecting hydrazine metabolized from isoniazid in living cells
Authors: Pang Shude , An Baoshuai , Miao Zhuo , Li Cheng , Wei Ningning , Zhang Yanru 
Published: January 2024

AbstractIsoniazid is a drug for treating tuberculosis, but hydrazine (N2H4), the major metabolite of isoniazid, can cause hepatotoxicity. Therefore, monitoring the content of N2H4 in time is of great significance for studying the hepatotoxicity induced by isoniazid. In this study, a near‐infrared fluorescent probe (BC‐N) was designed and synthesized based on the specific reaction of acetyl ester with N2H4. BC‐N exhibits excellent selectivity, sensitivity, and biocompatibility. In addition, BC‐N is applied in the visualization of N2H4 produced from isoniazid in living cells and is a potential tool for monitoring hepatotoxicity induced by isoniazid.
Giving the cells what they need when they need it: Biosensor‐based feeding control
Authors: Kinet Romain , Richelle Anne , Colle Michael , Demaegd Didier , von Stosch Moritz , Sanders Matthew , Sehrt Hannah , Delvigne Frank , Goffin Philippe 
Published: January 2024

Abstract“Giving the cells exactly what they need, when they need it” is the core idea behind the proposed bioprocess control strategy: operating bioprocess based on the physiological behavior of the microbial population rather than exclusive monitoring of environmental parameters. We are envisioning to achieve this through the use of genetically encoded biosensors combined with online flow cytometry (FCM) to obtain a time‐dependent “physiological fingerprint” of the population. We developed a biosensor based on the glnA promoter (glnAp) and applied it for monitoring the nitrogen‐related nutritional state of Escherichia coli. The functionality of the biosensor was demonstrated through multiple cultivation runs performed at various scales—from microplate to 20 L bioreactor. We also developed a fully automated bioreactor—FCM interface for on‐line monitoring of the microbial population. Finally, we validated the proposed strategy by performing a fed‐batch experiment where the biosensor signal is used as the actuator for a nitrogen feeding feedback control. This new generation of process control, —based on the specific needs of the cells, —opens the possibility of improving process development on a short timescale and therewith, the robustness and performance of fermentation processes.
Genetic algorithm‐based semisupervised convolutional neural network for real‐time monitoring of Escherichia coli fermentation of recombinant protein production using a Raman sensor
Authors: Liu Yuan , Zhou Xiaotian , Wang Teng , Luo An , Jia Zhaojun , Pan Xingquan , Cai Weiqi , Sun Mengge , Wang Xuezhong , Wen Zhenguo , Zhou Guangzheng 
Published: January 2024

AbstractAs a non‐destructive sensing technique, Raman spectroscopy is often combined with regression models for real‐time detection of key components in microbial cultivation processes. However, achieving accurate model predictions often requires a large amount of offline measurement data for training, which is both time‐consuming and labor‐intensive. In order to overcome the limitations of traditional models that rely on large datasets and complex spectral preprocessing, in addition to the difficulty of training models with limited samples, we have explored a genetic algorithm‐based semi‐supervised convolutional neural network (GA‐SCNN). GA‐SCNN integrates unsupervised process spectral labeling, feature extraction, regression prediction, and transfer learning. Using only an extremely small number of offline samples of the target protein, this framework can accurately predict protein concentration, which represents a significant challenge for other models. The effectiveness of the framework has been validated in a system of Escherichia coli expressing recombinant ProA5M protein. By utilizing the labeling technique of this framework, the available dataset for glucose, lactate, ammonium ions, and optical density at 600 nm (OD600) has been expanded from 52 samples to 1302 samples. Furthermore, by introducing a small component of offline detection data for recombinant proteins into the OD600 model through transfer learning, a model for target protein detection has been retrained, providing a new direction for the development of associated models. Comparative analysis with traditional algorithms demonstrates that the GA‐SCNN framework exhibits good adaptability when there is no complex spectral preprocessing. Cross‐validation results confirm the robustness and high accuracy of the framework, with the predicted values of the model highly consistent with the offline measurement results.
Stakeholder integration in sustainable business models to enhance value delivery for a broader range of stakeholders
Authors: Rathobei Kabelo Esther , Ranängen Helena , Lindman Åsa 
Published: January 2024

AbstractSustainable business models (SBMs) represent a contemporary approach seeking to deliver value to businesses and a wide range of stakeholders. This paper addresses the existing gap in practical guidance for businesses aiming to incorporate a wider range of stakeholders into their SBMs. To address the gap, a systematic review of academic literature and a review of mining company reports were conducted. The findings demonstrate that it is imperative to integrate stakeholders to achieve sustainability objectives, gain societal acceptance and foster legitimacy while maintaining alignment with stakeholders' concerns. To this end, the theoretical implication of this study lies in introducing a stakeholder integration model (SIM) that underscores the roles of identification, communication, knowledge sharing and continual improvement in achieving sustainability objectives and societal acceptance within SBMs. Practically, it addresses a gap by providing practical guidance for businesses to integrate stakeholders to manage risk, uncover value‐creation opportunities and gain social acceptance.
Accelerated partial breast irradiation: Current evidence and future developments
Authors: Song Dandan , Zhang Honghong , Ren Chengbo , Zhan Ning , Xie Liangxi , Xie Wenjia 
Published: January 2024

AbstractWhole breast irradiation after breast‐conserving surgery for early breast cancer has become one of the standard treatment modes for breast cancer and yields the same effect as radical surgery. Accelerated partial breast irradiation (APBI) as a substitute for whole breast irradiation for patients with early breast cancer is a hot spot in clinical research. APBI is characterised by simple high‐dose local irradiation of the tumour bed in a short time, thus improving convenience for patients and saving costs. The implementation methods of APBI mainly include brachytherapy, external beam radiation therapy, and intraoperative radiotherapy. This review provides an overview of the clinical effects and adverse reactions of the main technologies of APBI and discusses the prospects for the future development of APBI.