bluuebunny/crossref_metadata_2025_split huggingface dataset:
Root acclimations to soil flooding prime rice (Oryza sativa L.) for subsequent conditions of water deficit
Authors: Peralta Ogorek Lucas León , Song Zhiwei , Pellegrini Elisa , Liu Fulai , Tomasella Martina , Nardini Andrea , Pedersen Ole 
Published: October 2023

Abstract
Background and aims
The root barrier to radial O2 loss is a trait induced during soil flooding restricting oxygen loss from the roots to the anoxic soil. It can also restrict radial water loss, potentially providing tolerance towards drought during conditions of water deficit. Several root traits (aerenchyma and xylem vessels area) respond in a similar way to soil flooding and low soil water potentials. Therefore, we hypothesised that root acclimations to soil flooding prime plants to withstand conditions of water deficit.

Methods
We raised plants in hydroponics mimicking contrasting soil water conditions (aerated controls for well-watered soils; stagnant, deoxygenated solutions for flooded soils, and aerated solutions with different PEG6000 concentrations to mimic conditions of water deficit). We used O2 microsensors and gravimetric measurements to characterize the formation of a barrier to radial O2 loss during conditions of water deficit, and measured key anatomical root traits using light microscopy.

Results
Several root traits were induced in stagnant conditions as well as in conditions of water deficit, including the barrier to radial O2 loss. The tightness of the barrier to water loss was similar in both stagnant and PEG6000 treatments. Moreover, plants growing in stagnant conditions tolerated a following severe condition of water deficit, whereas those growing in mimicked well-watered conditions did not.

Conclusions
We demonstrated that plants growing in stagnant conditions can withstand following severe conditions of water deficit. We propose that key root traits, such as the barrier to radial O2 loss, which are induced in stagnant conditions as well as mild conditions of water deficit, prime the plants for a following severe condition of water deficit.
Exploring the role of the inflammasomes on prostate cancer: Interplay with obesity
Authors: Pérez-Gómez Jesús M. , Montero-Hidalgo Antonio J. , Fuentes-Fayos Antonio C. , Sarmento-Cabral André , Guzmán-Ruiz Rocio , Malagón María M. , Herrera-Martínez Aura D. , Gahete Manuel D. , Luque Raúl M. 
Published: October 2023

AbstractObesity is a weight-related disorder characterized by excessive adipose tissue growth and dysfunction which leads to the onset of a systemic chronic low-grade inflammatory state. Likewise, inflammation is considered a classic cancer hallmark affecting several steps of carcinogenesis and tumor progression. In this regard, novel molecular complexes termed inflammasomes have been identified which are able to react to a wide spectrum of insults, impacting several metabolic-related disorders, but their contribution to cancer biology remains unclear. In this context, prostate cancer (PCa) has a markedly inflammatory component, and patients frequently are elderly individuals who exhibit weight-related disorders, being obesity the most prevalent condition. Therefore, inflammation, and specifically, inflammasome complexes, could be crucial players in the interplay between PCa and metabolic disorders. In this review, we will: 1) discuss the potential role of each inflammasome component (sensor, molecular adaptor, and targets) in PCa pathophysiology, placing special emphasis on IL-1β/NF-kB pathway and ROS and hypoxia influence; 2) explore the association between inflammasomes and obesity, and how these molecular complexes could act as the cornerstone between the obesity and PCa; and, 3) compile current clinical trials regarding inflammasome targeting, providing some insights about their potential use in the clinical practice.
Simulations of Solar and Stellar Dynamos and Their Theoretical Interpretation
Authors: Käpylä Petri J. , Browning Matthew K. , Brun Allan Sacha , Guerrero Gustavo , Warnecke Jörn 
Published: October 2023

AbstractWe review the state of the art of three dimensional numerical simulations of solar and stellar dynamos. We summarize fundamental constraints of numerical modelling and the techniques to alleviate these restrictions. Brief summary of the relevant observations that the simulations seek to capture is given. We survey the current progress of simulations of solar convection and the resulting large-scale dynamo. We continue to studies that model the Sun at different ages and to studies of stars of different masses and evolutionary stages. Both simulations and observations indicate that rotation, measured by the Rossby number which is the ratio of rotation period and convective turnover time, is a key ingredient in setting the overall level and characteristics of magnetic activity. Finally, efforts to understand global 3D simulations in terms of mean-field dynamo theory are discussed.
Perfusion Computed Tomography as a Screening Tool for Pending Delayed Cerebral Ischemia in Comatose Patients After Aneurysmal Subarachnoid Hemorrhage: A Retrospective Cohort Study
Authors: Busse Thor Löwe , Munthe Sune , Ketharanathan Baskaran , Bülow Karsten , Jóhannsson Bjarni , Diaz Anabel , Nielsen Troels Halfeld 
Published: October 2023

Abstract
Background
Aneurysmal subarachnoid hemorrhage (aSAH) is frequently complicated by delayed cerebral ischemia (DCI), leading to poor outcomes. Early diagnosis of DCI is crucial for improving survival and outcomes but remains challenging in comatose patients. In this study, we aimed to evaluate computed tomography with angiography and perfusion (P-CT) as a screening modality on postictal days four and eight for impending DCI after aSAH in comatose patients using vasospasm with hypoperfusion (hVS) as a surrogate and DCI-related infarction as an outcome measure. Two objectives were set: (1) to evaluate the screening’s ability to accurately risk stratify patients and (2) to assess the validity of P-CT screening.

Methods
We conducted a retrospective review of the records of comatose patients with aSAH from January 2019 to December 2021 who were monitored with P-CT scans on days four and eight. The event rates of DCI-related infarction, hVS, and endovascular rescue therapy (ERT) were analyzed, and the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) for DCI were calculated. DCI-related infarction was defined as new secondary cerebral infarction > 48 h < 6 weeks post aSAH not attributable to other causes, and hVS was defined as arterial narrowing with corresponding hypoperfusion on P-CT.

Results
Fifty-six comatose patients were included, and 98 P-CT scans were performed. The incidence of DCI-related infarction was 40%. Screening P-CT on days four and eight found vasospasm in 23% of all patients, including 11% with hVS. A positive hVS on day four or eight revealed a relative risk of 2.4 [95% confidence interval (CI) 1.13–5.11, p = 0.03], sensitivity of 23% (95% CI 8–45, p = 0.03), specificity of 95% (95% CI 36–100, p = 0.03), PPV of 0.83 (95% CI 0.36–1.00, p = 0.03), and NPV of 0.65 (95% CI 0.50–0.78). Six positive P-CT scans led to digital subtraction angiography in five patients, three of whom received ERT. All ERT-intervened patients developed DCI-related infarction.

Conclusions
P-CT resulted in few interventions and often resulted in late detection of DCI at an irreversible stage. Although a positive P-CT result accurately predicts impending DCI-related infarction, screening on days four and eight alone in comatose patients with aSAH often fails to timely detect impending DCI. Based on our analysis, we cannot recommend P-CT as a screening modality. P-CT is likely best used as a confirmatory test prior to invasive interventions when guided by continuous multimodal monitoring; however, prospective studies with comparison groups are warranted. The need for a reliable continuous screening modality is evident because of the high rate of deterioration and narrow treatment window.
Roles of circRNAs in regulating the tumor microenvironment
Authors: Liu Tao , Long Kaijun , Zhu Zhengfeng , Song Yongxiang , Chen Cheng , Xu Gang , Ke Xixian 
Published: October 2023

AbstractCircRNAs, a type of non-coding RNA widely present in eukaryotic cells, have emerged as a prominent focus in tumor research. However, the functions of most circRNAs remain largely unexplored. Known circRNAs exert their regulatory roles through various mechanisms, including acting as microRNA sponges, binding to RNA-binding proteins, and functioning as transcription factors to modulate protein translation and coding. Tumor growth is not solely driven by gene mutations but also influenced by diverse constituent cells and growth factors within the tumor microenvironment (TME). As crucial regulators within the TME, circRNAs are involved in governing tumor growth and metastasis. This review highlights the role of circRNAs in regulating angiogenesis, matrix remodeling, and immunosuppression within the TME. Additionally, we discuss current research on hypoxia-induced circRNAs production and commensal microorganisms’ impact on the TME to elucidate how circRNAs influence tumor growth while emphasizing the significance of modulating the TME.
Sustainability conflicts in the blue economy: planning for offshore aquaculture and offshore wind energy development in Norway
Authors: Knol-Kauffman Maaike , Nielsen Kåre Nolde , Sander Gunnar , Arbo Peter 
Published: October 2023

AbstractBlue economy developments entail an industrialization of the world’s ocean and coastal areas, placing growing pressures on the marine environment and ecosystems. Moreover, the competition for ocean space and resources increases the likelihood for social conflicts. Marine spatial planning has been presented as a tool that can avoid or mitigate conflicts. However, there is a need for a more thorough analysis of the conflicts linked to the blue economy. The objective of this paper is to analyze characteristics of blue economy conflicts and how they are shaped by the institutional context and sustainability discourses. This study also explores perspectives on conflict management and pathways toward sustainable transformations in marine planning. Empirically, we use two case studies of blue growth industries in Norway: (1) offshore wind energy development and (2) offshore aquaculture development. Through these cases, we take a close look at the established principles and procedures which regulate conflicts. Our study shows how current blue economy conflicts are framed and handled through institutionalized practices of conflict management. Our findings are twofold. First, blue economy conflicts are not easily categorized through common conflict typologies (i.e., user-user, user-environment) but increasingly appear to be sustainability conflicts in which all actors use sustainability as a frame of reference for discussing possible and desirable futures. Second, conflicts are not necessarily a negative social process. In fact, conflicts often uncover unsustainable practices and create potential positive pathways for sustainable transformations.
Hypocalcemia in combination with hyperphosphatemia impairs muscle cell differentiation in vitro
Authors: Bimonte V. M. , Catanzaro G. , Spinello Z. , Massari M. C. , Curreli M. , Terrana G. , Defeudis G. , Halupczok-Żyła J. , Mantovani G. , Ferretti E. , Migliaccio S. 
Published: October 2023

Abstract
Purpose
Hypoparathyroidism is a rare endocrine disorder characterized by low or absent secretion of parathyroid hormone (PTH), which leads to decreased calcium and increased phosphorus levels in the serum. The diagnosis of hypoparathyroidism is based on the identification of the aforementioned biochemical abnormalities, which may be accompanied by clinical manifestations. Symptoms of hypoparathyroidism, primarily attributed to hypocalcemia, include muscle cramps or spasms, facial, leg, and foot pain, seizures, and tingling in the lips or fingers. The treatment of hypoparathyroidism depends on the severity of symptoms and the underlying pathology. Over the long term, calcium supplements, active vitamin D analogs, and thiazide diuretics may be needed. In fact, in patient cohorts in which optimal disease control still remains elusive, replacement therapy with recombinant parathyroid hormone analogs may be contemplated. Despite the predominantly neuromuscular symptoms of hypoparathyroidism, further effects of parathyroid hormone deficiency at the muscle cell level remain poorly understood. Thus, the aim of our study was to evaluate the effects of hypocalcemia in combination with hyperphosphatemia on muscle cells differentiation in vitro.

Methods
C2C12 cells, an in vitro model of muscle cells, were differentiated for 2 or 6 days in the presence of hypocalcemia (CaCl2 0.9 mmol/l) and moderate (PO4 1.4 mmol/l) or severe (PO4 2.9 mmol/l) hyperphosphatemia, or combinations of both conditions. Cell differentiation and expression of genes linked to muscle differentiation were evaluated.

Results
The combination of hypocalcemia with hyperphosphatemia induced a significant reduction (50%) in differentiation marker levels, such as MyoD (protein 1 for myoblast determination) and myogenin on the 1st day of differentiation, and MHC (myosin heavy chains) after 6 days of differentiation compared to control. Furthermore, this condition induced a statistically significant reduction of insulin-like growth factor-1 (IGF-1) mRNA expression and inhibition of IGF signaling and decrease in ERK phosphorylation compared to control cells.

Conclusions
Our results showed that a condition of hypocalcemia with hyperphosphatemia induced an alteration of muscle cell differentiation in vitro. In particular, we observed the reduction of myogenic differentiation markers, IGF-1 signaling pathway, and ERK phosphorylation in differentiated skeletal myoblasts. These data suggest that this altered extracellular condition might contribute to the mechanisms causing persistence of symptoms in patients affected by hypoparathyroidism.
Sedimentary facies controls on reservoir quality of the Abu Madi Formation, offshore Nile Delta Basin, Egypt
Authors: Assal Ehab M. , Farouk Sherif , Sarhan Mohammad A. 
Published: October 2023

AbstractThe present study investigates the sedimentological analysis and petrophysical properties of the Messinian Abu Madi reservoir (AMR), offshore Nile Delta Basin in order to determine how facies heterogeneities control reservoir quality. This approach was performed by integrating core data from Mina-1 well and BE-1 well and wireline logs from four wells (BN-1, BN-2, BE-3 and Mina-1). Based on core studies, seven clastic facies have been identified, of which five form sandstone reservoirs. These facies have accumulated within a deep incised canyon-fill during four successive fluvial sub-environments; braided fluvial channel, point bar, floodplain, and abandoned channel. These fluvial sediments were changed into tidally influenced fluvial/estuarine deposits with aggradational-retrogradational stacking patterns due to a transgressive event during the Messinian time. Based on the well log petrophysical evaluation, the Abu Madi reservoir has a total porosity of 0.20–0.26 v/v and effective porosity in the 0.18–0.25 v/v range. Shale volume ranges from 0.04 to 0.09 v/v, and water saturation ranges between 0.15 and 0.45 v/v. Four reservoir rock types were recognized and interpreted as a function of composition and therefore having different petrophysical characteristics. RRT1 and RRT2 show good petrophysical properties and good reservoir quality. The best reservoir quality occurs in massive sandstones (RRT3), which have porosities up to 26% and permeabilities up to 1440 mD. RRT4 has a poor reservoir quality with porosity of 5.4% and permeability of 0.6 mD. The reservoir porosity heterogeneities and reservoir quality have been strongly impacted by the original composition and primary depositional facies.
Solar energy for low carbon buildings: choice of systems for minimal installation area, cost, and environmental impact
Authors: Liu Renhua , He Guoqing , Su Yujie , Yang Yi , Ding De 
Published: October 2023

AbstractSolar application in buildings is limited by available installation areas. The performance of photovoltaic (PV) and solar collectors are compared in meeting the heating and cooling demand of a residential house using 100% solar energy through TRNSYS modelling of five systems that use air source heat pump and seasonal energy storage as optional assisting technologies. The results show that in a large scale, the PV working with air source heat pump is more efficient than the solar collector system. However, the photovoltaic/thermal (PV/T) is the most spatially efficient with an energy capacity of 551 kWh/m2, 10.6% higher than that of the PV. Compared with the air source heat pump heating system using grid power, using solar energy regardless of system formats can reduce emission by 72% in a lifetime of 20 years. Solar energy can become cost-effective if the utility price is increased to above 0.7 CNY/kWh. The results can help in renewable planning in the studied climate.
The ‘‘Monstrous tumor’’ of Adrenal gland: A case report and review of literature on adrenal teratomas
Authors: AlQattan Abdullah Saleh , AlSharit Mohammed Abdulmohsen , Alsaihaty Essra Zakarya , Eraqe Samma Tareq , Mashhour Miral , Alsaif Osama Habib 
Published: October 2023

Abstract

Introduction and clinical importance
Teratomas are neoplasms originating from pluripotent cells, rising from more than one or all three embryonic germinal layers. The nomenclature “Teratoma” is derived from the Greek word “teras” which translates to the word “monster”. One of the rarest locations is the adrenal gland, with adrenal teratomas representing only 0.13 % of all adrenal tumors.

Case presentation
A 36-year-old female, morbidly obese, was found to have a right adrenal mass after she presented to our surgical outpatient clinic with a complaint of abdominal pain. The mass was found on an abdominal computed tomography (CT) scan, which revealed a large retroperitoneal lesion measuring 29 × 15 × 22 cm and displacing the IVC, pancreas, duodenum, right kidney, and ascending colon. The differential diagnosis based on the patient’s workup was adrenal teratoma, myolipoma, angiolipoma, and liposarcoma. The patient underwent an uneventful open right adrenalectomy. The final histopathology confirmed the diagnosis of a mature right adrenal cystic teratoma weighing 4 kg. The last follow-up was 3 years postoperatively with no evidence of recurrence on CT scan.

Clinical discussion
A thorough discussion of the clinical presentations of the reported cases in the literature including the first reported case in the English literature. Furthermore, the use of the different modalities of diagnosis e.g., Ultrasonography, CT scan, and MRI. Also, the mainstay modality of treatment and the debate of minimal invasive laparoscopic adrenalectomy vs open adrenalectomy. Finally, the discussion of the period of following up the patient after successful operation and the removal of the tumor were presented.

Conclusion
Adrenal teratoma is extremely uncommon entity, with a great percentage of patient presenting with a non-specific presentation or are asymptomatic. Initial diagnosis might be made radiologically. However, a confirmatory diagnosis is based on the histopathological examination. The workup must rule out other possible differential diagnoses, like metastastis or functional tumors. Finally, surgical resection is the mainstay treatment of adrenal teratoma with an excellent survival rate.

Highlights
How are the relationships between childhood temperament, personality development and interpersonal function, and risk to depressive and other mood disorders, best conceptualised? What are the implications for preventive or treatment research?
Authors: Hickie Ian B. , Chanen Andrew 
Published: October 2023

One of the long-standing challenges in the field of depressive and other mood disorders is to have a clear conceptualisation of the relationships between childhood temperaments, personality development and adult self and interpersonal function, and depressive and other mood disorders. Some biologically-based dispositional (or temperamental) traits are present from birth and are relatively stable from infancy through to adulthood. These characteristics (e.g., anxious attachment or social inhibition) are commonly seen as ‘at-risk’ traits for later formal diagnoses of anxiety disorders in pre-pubertal children and anxiety and depression in teenagers (Compas et al., 2004; Rothbart, 2007).
In Defence of the Acquaintance Principle in Aesthetics
Authors: Sauchelli Andrea 
Published: October 2023

AbstractMaking an adequate aesthetic judgment about an object or an aesthetic property requires first-hand experience of that object or property. Many have suggested that this principle is a valid epistemic norm in the epistemology of the aesthetic. However, some recent philosophers have argued that certain works of conceptual art and other counterexamples disprove the principle in question, even suitably modified. In this paper, I argue that these philosophers are mistaken and that, when properly qualified, the acquaintance principle (in some of its versions) is not threatened by their examples and arguments.
Exponential multiple mixing for commuting automorphisms of a nilmanifold
Authors: BÉNARD TIMOTHÉE , VARJÚ PÉTER P. 
Published: October 2023

AbstractLet
$l\in \mathbb {N}_{\ge 1}$
and
$\alpha : \mathbb {Z}^l\rightarrow \text {Aut}(\mathscr {N})$
be an action of
$\mathbb {Z}^l$
by automorphisms on a compact nilmanifold
$\mathscr{N}$
. We assume the action of every
$\alpha (z)$
is ergodic for
$z\in \mathbb {Z}^l\smallsetminus \{0\}$
and show that
$\alpha $
satisfies exponential n-mixing for any integer
$n\geq 2$
. This extends the results of Gorodnik and Spatzier [Mixing properties of commuting nilmanifold automorphisms. Acta Math.215 (2015), 127–159].
K-stability of birationally superrigid Fano 3-fold weighted hypersurfaces
Authors: Kim In-Kyun , Okada Takuzo , Won Joonyeong 
Published: October 2023

AbstractWe prove that the alpha invariant of a quasi-smooth Fano 3-fold weighted hypersurface of index$1$is greater than or equal to$1/2$. Combining this with the result of Stibitz and Zhuang [SZ19] on a relation between birational superrigidity and K-stability, we prove the K-stability of a birationally superrigid quasi-smooth Fano 3-fold weighted hypersurfaces of index$1$.