bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex disparities in clinical features and burden of narcolepsy type 1
Authors: Ingravallo Francesca , Bassi Chiara , Zenesini Corrado , Vignatelli Luca , Pagotto Uberto , Pizza Fabio , Plazzi Giuseppe 
Published: February 2024

SummaryTo investigate potential sex‐related differences in patients with narcolepsy type 1, we carried out an analysis of baseline data from 93 women and 89 men with narcolepsy type 1 who participated in the TElemedicine for NARcolepsy (TENAR) trial. The following data were considered: sociodemographics; diagnostic (disease history, polysomnography, orexin, human leukocyte antigen) and clinical features, including sleepiness (Epworth Sleepiness Scale), cataplexy and other narcolepsy symptoms; disease severity (Narcolepsy Severity Scale); pharmacological treatment; depressive symptoms (Beck Depression Inventory); and self‐reported relevance of eight narcolepsy‐related issues. We found that, compared with men, significantly more women reported automatic behaviours (55.4% versus 40%) and had higher Epworth Sleepiness Scale (median 10 versus 9) and Beck Depression Inventory scores (median 10.5 versus 5), and there was a trend for a higher Narcolepsy Severity Scale total score in women (median 19 versus 18, p = 0.057). More women than men were officially recognized as having a disability (38% versus 22.5%) and considered 5/8 narcolepsy‐related issues investigated as a relevant problem. More severe sleepiness and a greater narcolepsy‐related burden in women could mirror sex differences present in the general population, or may be related to suboptimal management of narcolepsy type 1 or to more severe depressive symptoms in women. Future studies and guidelines should address these aspects.
Chemical compositions of Fe‐rich relict olivines from cosmic spherules, understanding their links with ordinary and carbonaceous chondrites
Authors: Fernandes D. , Rudraswami N. G. , Pandey M. , Singh V. P. 
Published: February 2024

AbstractFe‐rich relict olivine grains are found in a small percentage of cosmic spherules, which are studied here to determine the nature of their precursors. We examined 128 Fe‐rich relict olivine grains with Fa >10 mol% from 53 cosmic spherules of different types collected from Antarctica (Antarctica micrometeorites [AMM]) and deep‐sea sediments (DSS) of the Indian Ocean. Fe‐rich olivines identified in cosmic spherules are close analogs of type II chondrule olivines formed in the early solar system. The olivine analysis shows well‐defined trends in molar Fe/Mn versus Fe/Mg with an affinity for ordinary and carbonaceous chondrites. The minor oxides in olivine are in ranges such as MnO ~0.1–0.8 wt%, Cr2O3 ~0–0.7 wt%, CaO ~0–0.6 wt%, and Al2O3 ~0–0.2 wt%, respectively. The chemical composition suggests that the precursors for these Fe‐rich olivine‐bearing cosmic spherules consist of ordinary chondrites (~21%–23%, AMM‐DSS), carbonaceous chondrites (~17%–36%, AMM‐DSS), and a large fraction overlapping both carbonaceous and ordinary chondrites (~41%–62% AMM‐DSS). The elemental ratios Fe/Si/CI and Mg/Si/CI for the Fe‐rich relict olivines ranging between the values 0.5–1.0 and 1.1–1.7 are compatible with IDPs, Comet 81P/Wild 2 as well as the Asteroid Itokawa and Ryugu, which are indistinguishable from carbonaceous and ordinary chondrites. In addition, pyroxene and olivine assemblages in their Fa versus Fs mol% show strong similarities to EOC chondrites. Our results on Fe‐rich relict olivines show that these grains in cosmic spherules are less common than Mg‐rich olivines, which show a narrow range of chemical compositions identical to those from ordinary chondrites and carbonaceous chondrites, indicating a supplementary contribution of an ordinary chondritic component to the micrometeorite source of dust.
Large whale entanglements in Mexico, a 25‐year review from 1996 to 2021
Authors: Frisch‐Jordán Astrid , López‐Arzate Diana C. 
Published: February 2024

AbstractLarge whale entanglements are considered a significant threat to populations on a global scale. In the Mexican Pacific and Baja California Peninsula (1996–2021) a total of 218 confirmed entangled whales, from which 99 (45.4%) whales were fully released (66 by the Mexican Whale Disentanglement Network, known as RABEN). Five whale species were reported in confirmed entanglements: humpback (Megaptera novaeangliae, n = 187), gray (Eschrichtius robustus, n = 19), sperm (Physeter macrocephalus, n = 5), Bryde's (Balaenoptera edeni, n = 4), and fin (Balaenoptera physalus, n = 3). Eight types of fishing gear were identified out of 209 different gear sets; gill nets were the most common (n = 101, 48.3%), followed by pots (n = 49, 23.4%). Entanglements were reported in sixteen locations, and Banderas Bay had the most entanglement reports (n = 81, 32.8%). Several entanglements were tracked across multiple locations (n = 7), involving two teams with the most successful releases (n = 5), proving the efficiency of the RABEN entanglement response network. This information can be used to better understand entanglement impacts on large whales in the North Pacific and particularly in Mexico, to work towards mitigation of a problem that affects both whales and fishermen.
The Resurrection of the Flesh: the ‘Peculiar Treasure’ of the Church
Authors: Thompson Jon W. 
Published: February 2024

AbstractThis paper presents an argument for the recovery of the doctrine of the resurrection of the flesh. I argue that the doctrine accords with creedal and doctrinal tradition (§2), as well as the scriptural witness about the goodness and destiny of human flesh (§3). I then outline what it means to say – minimally – that the flesh (or ‘numerically the same body’) will be raised (§4). In §5, I argue that the doctrine speaks to the unique predicament of human beings, namely, that our very being (our flesh) is the site and source of our greatest fear – the fear of death. By focusing its proffered hopes on the same flesh in which our deepest fears are located, the promise of resurrection is shown to be a ‘peculiar treasure’. Finally, I suggest in §5a‐5c three practices by which the church can inculcate this hope in the face of death.
Measuring the needs of older adult patients in intensive care units: A translation and validation study of the NAPinICU questionnaire
Authors: Hussein Hanaa Abou El‐Soued , Hassan Eman Arafa , Baraka Azza Abd Elrazek , Al‐Gameel Magda Mahmoud Mohamed 
Published: February 2024

AbstractThe NAPinICU questionnaire, specifically designed to assess the needs of older adult patients in intensive care units, serves as a valuable tool for understanding and addressing their unique requirements. This study applied a cross‐cultural translation process, followed by a cross‐sectional survey to measure patients' needs and evaluate the psychometric properties of the Arabic‐translated version of the NAPinICU questionnaire. The older adults' translated questionnaire demonstrated high content validity, good test–retest reliability and acceptable internal consistency. Discriminative validity confirmed significant differences in needs ratings between university and private hospital patients. This translated and validated tool can help in assessing the needs of older adults in intensive care units. Assessment of these patients' needs assists in enhancing the quality of care delivered to them by nurses and other healthcare providers.
Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron
Authors: Gunn D. , Yeldho C. , Hoad C. , Menys A. , Gowland P. , Marciani L. , Spiller R. 
Published: February 2024

AbstractBackgroundLactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti‐diarrheal actions of ondansetron.MethodsA double‐blind, randomized, placebo‐controlled crossover study of the effect of ondansetron 8 mg in 16 healthy volunteers. Serial MRI scans were performed fasted and 6 h after a meal. Participants then received lactulose 13.6 g twice daily and study drug for a further 36 h. On Day 3, they had further serial MRI scans for 4 h. Measurements included small bowel water content (SBWC), colonic volume, colonic gas, small bowel motility, whole gut transit, and ascending colon relaxation time (T1AC), a measure of colonic water content.Key ResultsLactulose increased area under the curve (AUC) of SBWC from 0 to 240 min, mean difference 14.2 L · min (95% CI 4.1, 24.3), p = 0.009, and substantially increased small bowel motility after 4 h (mean (95% CI) 523 (457–646) a.u. to 852 (771–1178) a.u., p = 0.007). There were no changes in T1AC after 36 h treatment. Ondansetron did not significantly alter SBWC, small bowel motility, transit, colonic volumes, colonic gas nor T1AC, with or without lactulose.Conclusion & InferencesLactulose increases SBWC and stimulates small bowel motility; however, unexpectedly it did not significantly alter colonic water content, suggesting its laxative effect is not osmotic but due to stimulation of motility. Ondansetron's lack of effect on intestinal water suggests its anti‐diarrheal effect is not due to inhibition of secretion but more likely altered colonic motility.
Global pediatric anesthesia–Anglophone West Africa perspective
Authors: Desalu Ibironke , Sarpong Pokua , Osazuwa Maryrose O. , Ndikontar Kwinji Raymond , Faponle Aramide Folayemi , Suleiman Musa Kallamu , Metogo Mbengono epse Njoki Junette , Ilori Iniabasi , Eyelade Olayinka R. , Ohene Anastasia Abena , Anno Audrey , Addison William 
Published: February 2024

AbstractBackgroundThis article gives the pediatric anesthesia perspective from Cameroon, Nigeria, Ghana, Liberia, and Gambia, five out of six countries in Anglophone West Africa. Over 40% of the population of most of these countries are younger than 14 years and there is an increasing need for paediatric anesthesia services.FindingsWorkforce density ranges from 0.08 to 0.58 physician anesthesia providers per 100,000 population. There are only 13 trained pediatric anesthetists; ratios range from 0 to 0.4 per 100,000 children, thus pediatric anesthesia services are provided by various cadres of physician and non‐physician anesthesia providers. Physician anesthesia training is mostly carried out by the West African College of Surgeons as well as national postgraduate colleges. Pediatric anesthesia services are provided in tertiary (teaching), secondary (general), district, faith‐based, military, private hospitals and through surgical missions. Challenges include lack of trained personnel, high morbidity from late presentation to health facilities and financial constraints, lack of health insurance for pediatric anesthesia services, unavailability of appropriate equipment and consumables, a narrow range of medications, very few pediatric‐specific operating theaters, and inadequate critical care services.SolutionsThe lack of opportunities for sub‐specialty training in pediatric anesthesia in West Africa is currently being addressed in Nigeria and Ghana. Non‐governmental agencies fund programs and courses related to pediatric anesthesia and have also provided fully equipped operating theaters. Advocacy for pediatric anesthesia can be achieved through the National Surgical Obstetric Anesthesia and Nursing Plans Implementation Committee of the various countries. There is an urgent need for prioritization of health in the budgets of Anglophone West African countries and governments must deliberately provide support for anesthesia and surgical services. More international collaborations towards workforce training and creation of children's hospitals are needed.
Restricted internal diffusion weakens transpiration–photosynthesis coupling during heatwaves: Evidence from leaf carbonyl sulphide exchange
Authors: Sun Wu , Maseyk Kadmiel , Lett Céline , Seibt Ulli 
Published: February 2024

AbstractIncreasingly frequent and intense heatwaves threaten ecosystem health in a warming climate. However, plant responses to heatwaves are poorly understood. A key uncertainty concerns the intensification of transpiration when heatwaves suppress photosynthesis, known as transpiration–photosynthesis decoupling. Field observations of such decoupling are scarce, and the underlying physiological mechanisms remain elusive. Here, we use carbonyl sulphide (COS) as a leaf gas exchange tracer to examine potential mechanisms leading to transpiration–photosynthesis decoupling on a coast live oak in a southern California woodland in spring 2013. We found that heatwaves suppressed both photosynthesis and leaf COS uptake but increased transpiration or sustained it at non‐heatwave levels throughout the day. Despite statistically significant decoupling between transpiration and photosynthesis, stomatal sensitivity to environmental factors did not change during heatwaves. Instead, midday photosynthesis during heatwaves was restricted by internal diffusion, as indicated by the lower internal conductance to COS. Thus, increased evaporative demand and nonstomatal limitation to photosynthesis act jointly to decouple transpiration from photosynthesis without altering stomatal sensitivity. Decoupling offered limited potential cooling benefits, questioning its effectiveness for leaf thermoregulation in xeric ecosystems. We suggest that adding COS to leaf and ecosystem flux measurements helps elucidate diverse physiological mechanisms underlying transpiration–photosynthesis decoupling.
Redox regulation of chromatin remodelling in plants
Authors: Plskova Zuzana , Van Breusegem Frank , Kerchev Pavel 
Published: February 2024

AbstractChanges in the cellular redox balance that occur during plant responses to unfavourable environmental conditions significantly affect a myriad of redox‐sensitive processes, including those that impact on the epigenetic state of the chromatin. Various epigenetic factors, like histone modifying enzymes, chromatin remodelers, and DNA methyltransferases can be targeted by oxidative posttranslational modifications. As their combined action affects the epigenetic regulation of gene expression, they form an integral part of plant responses to (a)biotic stress. Epigenetic changes triggered by unfavourable environmental conditions are intrinsically linked with primary metabolism that supplies intermediates and donors, such acetyl‐CoA and S‐adenosyl‐methionine, that are critical for the epigenetic decoration of histones and DNA. Here, we review the recent advances in our understanding of redox regulation of chromatin remodelling, dynamics of epigenetic marks, and the interplay between epigenetic control of gene expression, redox signalling and primary metabolism within an (a)biotic stress context.
“Go Back To Where You Came From!”: Moral Economy of Land and the Politics of Belonging in Coastal Tanzania☆
Authors: Chung Youjin B. 
Published: February 2024

AbstractThis article examines how the threat of eviction by a transnational land deal in coastal Tanzania shaped competing narratives with which longtime residents and migrants defended and legitimated the moral economy of land: a widely shared customary norm that land belonged to those who cleared, occupied, and used it continuously for their daily provisioning, with or without title deeds. To counter the state's claim that all villagers were “invaders,” long‐term residents appealed to their ethnic and ancestral connections to the land, while migrants invoked a broader idiom of agrarian citizenship that placed land entitlements at the heart of rural people's relationship with the state. Despite this divergence, nervousness similarly pervaded both group's narratives, due in part to the instability of the notion of ethnicity and autochthony in coastal Tanzania and people's historically informed sense of foreboding about state‐sanctioned dispossession. The article draws on the analytic of assemblage to advance a more relational and dynamic understanding of the co‐construction and performance of moral economy and rural identity. Analyzing how villagers imagine and articulate their identities, and how discourses of exclusion and belonging get deployed in conjunctures of displacement is critical to understanding the socio‐material realities of rural life in Tanzania today.
Primary hyperoxaluria: Description of a new oral finding and review of literature
Authors: Hassona Yazan , Hassan Sora , Atef Alaa , Flaifl Yara , AlShammas Faris , Abdaljaleel Maram 
Published: February 2024

AbstractObjectivesOro‐dental manifestations of hyperoxaluria and dental management of affected patients are rarely reported in the literature. We describe a new oral presentation of primary hyperoxaluria (PH) and review relevant literature about oro‐dental manifestations and management of dental complications of hyperoxaluria.MethodsA case report of a 44‐year‐old female who presented with symptoms of temporomandibular joint dysfunction due to hyperoxaluria was described according to the CARE guidelines. In addition, an extensive search of biomedical databases (PubMed, Medline, Google Scholar, and Embase) for articles describing oro‐dental manifestations and/or dental management in patients with hyperoxaluria was performed using the key words (“oral” and/or “hyperoxaluria” and/or “dental” and/or “oxalosis”). Included articles were reviewed and data about patient demographics, disease type and stage, oral and dental manifestations, and dental treatment outcome were retrieved and analyzed.ResultsA total of 14 articles describing the oral and dental manifestations in 15 patients with hyperoxaluria were included. Tooth mobility, root resorption, and radiographic alterations were consistently described in all cases. Oral manifestations were described mainly in PH at late stages, and only after the onset of chronic renal disease. Dental management in all reported cases was palliative and aimed to relive pain and treat periodontal infection. Tooth loss due to extraction or uncontrolled mobility was the ultimate outcome in almost all reported cases.ConclusionOral and dental manifestations in hyperoxaluria are rarely reported in the literature. Management of tooth mobility and root resorption in hyperoxaluria is challenging and clinical guidelines and evidence‐based recommendations are lacking. Early diagnosis and treatment of hyperoxaluria might be the only effective approach to prevent dental and periodontal complications of the disease.
MdWER interacts with MdERF109 and MdJAZ2 to mediate methyl jasmonate‐ and light‐induced anthocyanin biosynthesis in apple fruit
Authors: Zhang Xi , Yu Lujia , Zhang Mengjiao , Wu Ting , Song Tingting , Yao Yuncong , Zhang Jie , Tian Ji 
Published: February 2024

SUMMARYAnthocyanin generation in apples (Malus domestica) and the pigmentation that results from it may be caused by irradiation and through administration of methyl jasmonate (MeJA). However, their regulatory interrelationships associated with fruit coloration are not well defined. To determine whether MdERF109, a transcription factor (TF) involved in light‐mediated coloration and anthocyanin biosynthesis, has synergistic effects with other proteins, we performed a yeast two‐hybrid assessment and identified another TF, MdWER. MdWER was induced by MeJA treatment, and although overexpression of MdWER alone did not promote anthocyanin accumulation co‐overexpression with MdERF109 resulted in significantly increase in anthocyanin biosynthesis. MdWER may form a protein complex with MdERF109 to promote anthocyanin accumulation by enhancing combinations between the proteins and their corresponding genes. In addition, MdWER, as a MeJA responsive protein, interacts with the anthocyanin repressor MdJAZ2. Transient co‐expression in apple fruit and protein interaction assays allowed us to conclude that MdERF109 and MdJAZ2 interact with MdWER and take part in the production of anthocyanins upon MeJA treatment and irradiation. Our findings validate a role for the MdERF109‐MdWER‐MdJAZ2 module in anthocyanin biosynthesis and uncover a novel mechanism for how light and MeJA signals are coordinated anthocyanin biosynthesis in apple fruit.
Development of a reference interval for urinary ammonia‐to‐creatinine ratio in feline patients
Authors: Brown Eleanor E. , Castro Rebecca A. , Griffin Francesca C. , Mandese Wendy W. , Rooks Jenna K. , Stone Amy E. , Wuerz Julia A. , Cooke Kirsten L. , Specht Andrew J. , Harris Autumn N. 
Published: February 2024

AbstractBackgroundDisruption of acid–base homeostasis can lead to many clinical problems. Ammonia excretion by the kidneys is critical to maintaining acid–base homeostasis through bicarbonate production. Measurement of ammonia excretion may help determine if the kidneys are properly functioning in maintaining acid–base balance. Reference intervals are essential tools for clinical decision‐making but do not currently exist for urinary ammonia‐to‐creatinine ratio (UACR) in feline patients.ObjectiveThis study aimed to generate a reference interval (RI) for UACR in healthy adult cats.MethodsThe study used samples from client‐owned adult healthy cats that presented to the University of Florida Primary Care and Dentistry service (n = 92). Physical examination, serum biochemistry, urinalysis, urine ammonia, and creatinine concentrations were measured. Cats were excluded if there were significant abnormalities in their urinalysis or biochemistry panel. The RI for UACR was calculated according to the recommendation of the American Society for Veterinary Clinical Pathology. The UACR was evaluated for correlation with serum bicarbonate, weight, age, and sex.ResultsThe RI for UACR was 3.4–20.7 with 90% confidence intervals for the lower and upper limits of (3.0–3.7) and (16.0–23.7), respectively. No significant correlation with age, sex, or weight was found. There was no discernable relationship between serum bicarbonate and UACR.ConclusionsEstablishing an RI for UACR in healthy adult cats will allow further studies to determine if changes in UACR are observed during specific disease states.
Comparison of visual outcomes between medical treatment alone and Ahmed glaucoma valve implantation in Shiba dogs with primary angle closure glaucoma
Authors: Kubo Akira , Ito Yosuke 
Published: February 2024

AbstractObjectiveThe objective of the study was to evaluate visual outcomes between medical treatment alone (MED) and Ahmed glaucoma valve implantation (AGVI) in Shiba dogs with primary angle closure glaucoma (PACG).ProceduresRecords of 65 Shiba dogs (104 eyes) with PACG were retrospectively reviewed. Vision was assessed qualitatively using both the menace response and maze testing. The significance of age, sex, intraocular pressure (IOP), and duration of clinical signs (≤72 h or >72 h) at first presentation (V1) was assessed. Eyes with vision at V1 were divided into groups according to subsequent treatment method (MED versus AGVI), and vision as a survival outcome was compared between group by the Kaplan–Meier method.ResultsAt V1, 65 eyes (62.5%) of 54 dogs had vision. There was no statistically significant difference in age or sex on the presence of vision at V1. Median IOP was higher in blind (52 mmHg) compared to sighted eyes (28 mmHg) (p < .001). Eyes presenting in ≤72 h of the onset of clinical signs were more likely to have vision (86.7%) compared to those presenting after 72 h (44.1%) (p < .001). By the Kaplan–Meier analysis, the cumulative visual retention rate was significantly higher with AGVI than with MED (69.2% vs. 7.7%; p < .01) at 12 months. The median time to visual loss was 39.9 months with AGVI vs. 1.7 months with MED.ConclusionsAGVI resulted in better visual outcomes than MED and should be considered in Shiba dogs with PACG that are visual at the time of presentation and suitable for surgery.