bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health information technology use among foreign-born adults of Middle Eastern and North African decent in the United States
Authors: Smith Alexandra , Kindratt Tiffany 
Published: October 2023

Abstract

Health information technology (HIT) use among foreign-born adults of Middle Eastern and North African (MENA) descent living in America is an understudied population. They are currently categorized as “White” in the United States (US) on federal forms. The purpose was to uncover the prevalence of HIT use among MENA immigrants compared to US- and foreign-born White adults before and after adjusting for other factors. The 2011–2018 National Health Interview Survey data (n = 161,613; ages 18 + years) was analyzed. HIT uses evaluated were searching for health information, filling prescriptions, scheduling appointments, and communicating with healthcare providers via email (last 12 months). Crude and multivariable logistic regression models were used to estimate the odds of each HIT use, any HIT use, and all HIT uses before and after adjustment. The most common HIT use was looking up health information, with 46.4% of foreign-born adults of MENA, 47.8% of foreign-born White, and 51.2% of US-born White adults reporting its use (p = .0079). Foreign-born adults of MENA descent had lower odds (OR = 0.64; 95%CI = 0.56–0.74) of reporting any HIT use, but no difference in reporting all HIT uses compared to US-born White adults in adjusted models. This is the first study to explore HIT use among Americans of MENA descent. Patterns of HIT use among adults of MENA descent differ from White adults. Results contribute to growing body of literature showing the health of Americans of MENA descent differs from White Americans. A separate racial/ethnic identifier is needed to better capture HIT uses among populations of MENA descent.
Raman spectroscopic measurements on San Carlos olivine up to 14 GPa and 800 K: Implications for thermodynamic properties
Authors: Liu Dan , Song Haipeng , Zhu Xi , Ye Yu , Smyth Joseph R. , Hu Yancheng , Wang Sha , Miao Yunfan , Liu Yungui 
Published: October 2023

Abstract
Olivine, the most abundant mineral in the upper mantle, plays a key role in controlling the thermodynamic properties in the Earth’s and planetary interiors, like the temperature distribution along the adiabatic geotherm. In this study, we conducted simultaneous high-pressure (P) and high-temperature (T) Raman measurements on a San Carlos olivine sample in an externally heated diamond-anvil cell (DAC). The intrinsic anharmonic parameters, ai, are calculated as functions of both pressure and temperature, and the isochoric (CV) and isobaric (CP) heat capacities are computed at various P-T conditions with the anharmonic correction. The harmonic heat capacities are CV = 807.7 J/kg/K and CP = 815.4 J/kg/K at ambient conditions, with anharmonic contribution of ΔC = 7.9 J/kg/K. Relative to the previous vibrational measurements conducted at high-P or high-T conditions, this simultaneous high-P-T experiment indicates that the anharmonic contribution to heat capacities is overestimated if the anharmonic parameters (ai) are treated as constants, as done previously. The pressure effect is marginal on the intrinsic anharmonic contribution to thermodynamic properties, whereas it has a much more significant effect on the external anharmonicity (thermal expansivity). The pressure dependence of CP (dCP/dP, in J/kg/K/GPa) increases from –3.14 at 300 K to –1.94 at 700 K, and then decreases smoothly to –5.03 at 1800 K. Combining the derived high-P-T capacity with a reliable P-V-T equation of state (EoS) for olivine, we further modeled the thermodynamic Grüneisen parameter, γ(P-T). The Grüneisen parameter is important for the connection between isothermal and adiabatic compressions of minerals, which can be decreased by approximately 5% with the anharmonic correction at high temperatures. The modeled adiabatic bulk modulus and bulk sound velocity can be expressed as: KS(T,P) (GPa) = 127.5(1) + 4.32(5)∙P – 0.018(1)∙(T – 300) and VΦ(T-P) (km/s) = 6.22(2) + 0.069(3)∙P – [3.74(15)–0.075(13)∙P]∙10–4∙(T – 300). The adiabatic temperature gradient, dTS/dP, which is almost independent of pressure, equals 13.40(16) and 12.35(16) K/GPa in the harmonic and anharmonic models, respectively. This study provides a useful example for modeling the radial temperature distribution in adiabatic planetary mantles.
Medical Image Processing based on Generative Adversarial Networks: A
Systematic Review
Authors: Liu Jun , Li Kunqi , Dong Hua , Han Yuanyuan , Li Rihui 
Published: October 2023

Background::
Generative adversarial networks (GANs) have demonstrated superior data generation capabilities compared to other methods, making them
popular for use in medical image applications. These features have intrigued researchers in the medical imaging field, resulting in a swift
implementation of these techniques in various conventional and novel applications such as image reconstruction, segmentation, detection,
classification, and cross-modality synthesis. A comprehensive review of recent medical imaging breakthroughs will benefit researchers interested
in this field. In this review, we aimed to introduce the origin, principle, and extended forms of GANs and summarize the state-of-the-art progress
of GAN-based medical image processing methods.

Methods::
We searched the literature for studies on Google Scholar and PubMed using the keywords “Segmentation,” “Classification,” “medical image,” and
“generative adversarial network.” Specifically, the initial search revealed 5423 publications after the removal of duplicated and non-accessible fulltext
publications. Then, after the title and abstract screening, 680 underwent full-text screening. Finally, 121 studies were included in our final
analysis after full-text screening.

Results::
The date range of the studies covered in this review is from January 1, 2017, to the present. After a thorough screening and qualification
assessment, 121 studies involving GAN-based applications in seven areas of medical images were included in the final methodological review.
These areas included synthesis, classification, segmentation, conversion, reconstruction, denoising, and lesion detection. We further classified and
summarized these papers into clinical applications, classification methods, and imaging modalities.

Conclusion::
We thoroughly examined the latest research progress of GAN-based medical image augmentation. These techniques effectively alleviate the
challenge of limited training samples for medical image diagnosis and treatment models. Furthermore, several critical issues associated with
GANs, such as pattern collapse, instability, and lack of interpretability, require attention in future research.
A Rapid and Sensitive UPLC-MS/MS Method for the Determination of
Bellidifolin and Pharmacokinetics Study of Bellidifolin Nano-microcells
Authors: Tian Jiaye , Bai Ran , Chen Ziyue , Qin Piaoran , Liu XingChao , Shen Haoran , Zhou Li , Guo Qiuhong 
Published: October 2023

Background:
Bellidifolin (BEL) has a decent enemy of myocardial fibrosis impact, and
its preparation into nano-micelles can build security and great biocompatibility in vitro and in vivo.
The pharmacokinetic assessment of BEL can be utilized as the reason for the security and viability
of BEL in clinical use.

Objective:
This research aimed to establish an effective UPLC-MS/MS strategy for assuring BEL
in rodent plasma and concentrating on its pharmacokinetics in vivo.

Methods:
Luteolin was utilized as an internal standard (IS). Chromatographic separation was accomplished
utilizing a UPLC HSS T3 column (2.1 ×100 mm, 1.8 μm) section using a mobile phase
of 0.1% acetonitrile (A) and 0.1% formic acid in water (B) with gradient elution. Electrospray ionization
(ESI) coupled mass spectrometry was applied in various response checking (MRM) modes
with negative ionization.

Results:
The pharmacokinetic behaviour of bellidifolin nano-micelles in vivo showed that the peak
concentration (Cmax) was 1666.19±479.92 μg/L, the time to peak (Tmax) was 0.167 h, and the apparent
elimination half-life (t1/2) was 7.60±3.58 h. The plasma clearance rate (CL/F) was
1.15±0.48 L/h/kg, the apparent volume of distribution (V/F) was 14.38±11.04, the area under the
curve (AUC) was 8292.57±4193.13 μg/L*h, and the mean retention time (MRT) was 9.70±4.55 h.

Conclusion:
The method was successfully applied to the plasma pharmacokinetics of bellidifolin
nano-micelles after intragastric administration to rats.
SYSTEMATIC REVIEW DAN META-ANALISIS : ANALISIS DAMPAK INTERVENSI APOTEKER TERHADAP CLINICAL OUTCOME PASIEN EPILEPSI
Authors: Salsabila Najmah 
Published: October 2023

Penderita epilepsi umumnya mengalami gangguan kontak sosial dan juga penurunan kesehatan. Peran Apoteker dalam pelaksanaan terapi pasien epilepsi sangat penting dalam memberikan pelayanan kefarmasian. Penelitian ini dilakukan untuk mengkaji bagaimana dampak intervensi Apoteker terhadap clinical outcome pasien epilepsi. Penelitian ini merupakan penelitian systematic review dan meta-analisis dengan desain studi Randomized Controlled Trial. Artikel yang diperoleh melalui database elektronik seperti PubMed, Directory of Open Access Journal (DOAJ), Springerlink, Sciencedirect, dan Wiley. Total terdapat 10 artikel dari berbagai negara yaitu dari negara Inggris, Singapore, China, Thailand, Colombia, Amerika, dan Nigeria. Data yang didapatkan bahwa intervensi Apoteker mampu berdampak positif dengan meningkatkan clinical outcome pasien epilepsi dibandingkan dengan tanpa adanya Apoteker (SMD= 0.56; 95% CI= 0.03 hingga 1.10; p=0.04). Kemudian terdapat heterogenitas (I2 ) yang tinggi antar eksperimen (I2= 96%; p<0.001), hal tersebut dikarenakan variasi populasi yang berbeda-beda. Selanjutnya, dari hasil penggabungan ke-10 artikel ini ditemukan adanya bias publikasi dilihat dari grafik funnel plot terlihat tidak simetris antara plot kanan dan kiri. Intervensi yang diberikan oleh Apoteker yaitu konsulasi dan konseling terbukti berdampak positif terhadap hasil clinical outcome pasien epilepsi berupa peningkatan kualitas hidup dari penurunan frekuensi kejang dan peningkatan pengetahuan pasien epilepsi. Kata kunci : Apoteker, clinical outcome, epilepsi
Combined Antidiabetic and Antidyslipidemic Activity of Ageratum conyzoides and Gynura procumbens in Alloxan-induced Diabetic Rats
Authors: Mulyani Yani , Mastura Nazarul , Rosilopya Salsha , Suhardiman Aris , Fajarwati Kania , Sutrisno Entris 
Published: October 2023

Unhealthy lifestyle habits greatly increase the risks of various degenerative illnesses, for example, diabetes mellitus as well as dyslipidemia. Recent studies have shown that the pharmaceutical drugs used for the treatment of these conditions have undesirable side effects. This indicates that it is necessary to find more effective and safe alternative treatment options, particularly in medicinal plants, such as Ageratum conyzoides and Gynura procumbens. Therefore, this research examined the combined antidiabetic and antidyslipidemic activity of Ageratum conyzoides and Gynura procumbens extracts in alloxan-induced diabetic rats. The insulin sensitivity of the test animals was assessed at the beginning of the experiment using the oral glucose tolerance test (OGTT) through the administration of 3 g/kgBW glucose. Pancreatic destruction was induced with the intraperitoneal injection of a single dose of 150 mg/kgBW alloxan, and the rats were treated with ethanol extract for 14 days. High-density lipoprotein cholesterol (HDL-C), Triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) were measured using the enzymatic method. The results showed that the single extracts and their combination exhibited high antidiabetic and antidyslipidemic activity. This was indicated by a substantial reduction in fasting blood sugar, TG, TC, and LDL-C (p<0.05), and an insignificant increase in HDL-C. The activity of the combined extract was similar to the single extracts, but it was not better in decreasing TG levels. Based on these findings, 95% ethanol extract of Ageratum conyzoides, Gynura procumbens, and their combination exhibited high antidiabetic and antidyslipidemic activity in alloxan-induced rats.
Effect of Intensive Blood Pressure Control on Kidney Outcomes
Authors: Drawz Paul E. , Lenoir Kristin M. , Rai Nayanjot Kaur , Rastogi Anjay , Chu Chi D. , Rahbari-Oskoui Frederic F. , Whelton Paul K. , Thomas George , McWilliams Andrew , Agarwal Anil K. , Suarez Maritza Marie , Dobre Mirela , Powell James , Rocco Michael V. , Lash James P. , Oparil Suzanne , Raj Dominic S. , Dwyer Jamie P. , Rahman Mahboob , Soman Sandeep , Townsend Raymond R. , Pemu Priscilla , Horwitz Edward , Ix Joachim H. , Tuot Delphine S. , Ishani Areef , Pajewski Nicholas M. 
Published: October 2023

Background
Intensive BP lowering in the Systolic Blood Pressure Intervention Trial (SPRINT) produced acute decreases in kidney function and higher risk for AKI. We evaluated the effect of intensive BP lowering on long-term changes in kidney function using trial and outpatient electronic health record (EHR) creatinine values.

Methods
SPRINT data were linked with EHR data from 49 (of 102) study sites. The primary outcome was the total slope of decline in eGFR for the intervention phase and the post-trial slope of decline during the observation phase using trial and outpatient EHR values. Secondary outcomes included a ≥30% decline in eGFR to <60 ml/min per 1.73 m2 and a ≥50% decline in eGFR or kidney failure among participants with baseline eGFR ≥60 and <60 ml/min per 1.73 m2, respectively.

Results
EHR creatinine values were available for a median of 8.3 years for 3041 participants. The total slope of decline in eGFR during the intervention phase was −0.67 ml/min per 1.73 m2 per year (95% confidence interval [CI], −0.79 to −0.56) in the standard treatment group and −0.96 ml/min per 1.73 m2 per year (95% CI, −1.08 to −0.85) in the intensive treatment group (P < 0.001). The slopes were not significantly different during the observation phase: −1.02 ml/min per 1.73 m2 per year (95% CI, −1.24 to −0.81) in the standard group and −0.85 ml/min per 1.73 m2 per year (95% CI, −1.07 to −0.64) in the intensive group. Among participants without CKD at baseline, intensive treatment was associated with higher risk of a ≥30% decline in eGFR during the intervention (hazard ratio, 3.27; 95% CI, 2.43 to 4.40), but not during the postintervention observation phase. In those with CKD at baseline, intensive treatment was associated with a higher hazard of eGFR decline only during the intervention phase (hazard ratio, 1.95; 95% CI, 1.03 to 3.70).

Conclusions
Intensive BP lowering was associated with a steeper total slope of decline in eGFR and higher risk for kidney events during the intervention phase of the trial, but not during the postintervention observation phase.
Islamic and Scientific Views on The Law of Using Urine Samples as Candidates for Early Detection of Cancer
Authors: Prasetyo Angga Dwi 
Published: October 2023

Abstract
The growing prevalence of cancer patients is a significant obstacle to global human growth. Prostate carcinoma is one of the types of cancer that kills the most men. The second most frequently diagnosed kind of carcinoma is prostate cancer (Pca), which is also the sixth biggest cause of death in males globally. Urine can be a candidate for early diagnosis of non-invasive cancer, however the rule on the use of urine as a sample in Islam has not yet been thoroughly addressed. Prostate cancer testing is still an intrusive procedure. The goal of this study was to ascertain the legality of using urine samples as potential candidates for the early identification of cancer from both an Islamic and scientific standpoint. Meta-analysis is combined with a qualitative methodology. According to the study's findings, urine may be a candidate for the early detection of cancer. Legally speaking, urine can be used as long as it is not applied directly to patients either topically or orally in order to prevent it from becoming haram. This is because the authors were unable to find any evidence to support the prohibition of using urine on patients.
Printed Digital Wax-up Model as a Blueprint for Layered Pressed-ceramic Laminate Veneers: Technique Description and Case Report
Authors: Jurado CA , Villalobos-Tinoco J , Mekled S , Sanchez R , Afrashtehfar KI 
Published: October 2023

SUMMARY
This article presents a clinical technique for transferring Digital Smile Design (DSD) information and a digital wax-up to fabricate highly personalized ceramic laminate veneers. The hybrid workflow of digitally designed wax-up and conventional hand-crafted veneers is showcased in a female adult who sought to improve her smile due to maxillary anterior incisal wear. The ceramic veneers, layered by feldspathic porcelain, followed the contours and shade blueprint planned with the digital wax-up. The DSD improved the harmony of the facial-and-smile relationship, and the ceramic restorations fulfilled the patient’s esthetic and functional demands. Guides based on the printed model with the digitally designed wax-up can provide a reference for pressed lithium disilicate veneers layered with feldspathic porcelain.
THE INFLUENCE OF USING CODI ON STUDENT’S MOTIVATION IN READING
Authors: Ningrum Saraswati Eko , Fauziati Endang , Prastiwi Yeny 
Published: October 2023

Students' reading motivation is likely low due to internal and external factors. The internal factors, for example, are intelligence, age, gender, reading ability, attitudes, and psychological needs. The external factors include the theme, level of reading difficulty, and the type of reading. This research was conducted to know whether the use of Content Differentiated Instructions (CoDI) in teaching could affect students' motivation in reading, especially descriptive text. This kind of text was chosen because it is the simplest text among five other kinds of text that are given to beginner-level students, in this case, students of junior high school. The researcher tried to find out whether the implementation of CoDI could affect the students’ motivation in reading. In this study, the researcher used a qualitative method. The data used were in the form of answers or student responses in the form of questionnaires. The result was that using CoDI affects the students’ motivation in reading descriptive text.
Examining the Impact of Interdisciplinary Practices on Secondary School Students' Awareness of Sustainable Living
Authors: YÜZBAŞIOĞLU Mustafa Kemal 
Published: October 2023

Purpose: This study aimed to determine the effect of the practices carried out according to an interdisciplinary approach on students' awareness of sustainable living.
Methodology: In the present study, one group pre-test post-test experimental design, one of the quasi-experimental methods, was used. A total of 46 activities were carried out in 33 weeks of the academic year within the scope of 11 different courses and social club practices with 37 secondary school students who participated in the study. The study data were collected using the Sustainable Living Awareness Scale.
Findings: As a result of the activities carried out, students' awareness of sustainable living increased significantly on an overall scale and in the social, economic, and environmental sub-dimensions of the scale.
Highlights: The present study concluded that the activities carried out over a long period with an interdisciplinary approach reflected positively on the awareness of the students. It is recommended to take steps to make teacher candidates and teachers aware of the concept of sustainable development and for the development of teacher candidates and teachers on sustainable development.
Glial Fibrillary Acidic Protein sebagai Penanda Prognostik pada Stroke Iskemik Akut
Authors: Amalia Lisda 
Published: October 2023

Stroke merupakan kegawatdaruratan neurologi yang timbul mendadak dan merupakan penyebab kematian nomor tiga terbanyak di negara dunia setelah penyakit jantung dan kanker. Stroke iskemik merupakan penyebab paling banyak yaitu 87% dari keseluruhan kasus stroke. Penanda biologik dibutuhkan untuk dapat menggambarkan kerusakan sel saraf otak sehingga dapat membantu klinisi untuk menegakkan diagnosis stroke iskemik. Salah satu penanda tersebut yaitu Glial Fibrillary Acidic Protein (GFAP) serum yang diekspresikan oleh sel glia otak yaitu astrosit. Astrosit merupakan sel glia yang terbanyak dalam sistem saraf pusat (SSP) yang berperan penting untuk menjaga fungsi fisiologis dan menjaga homeostasis otak. Astrosit adalah sel yang paling awal dan paling responsif bereaksi bila terjadi iskemia otak. Pada saat terjadi iskemia otak akan terjadi hipertrofi sel astrosit yang disebut sebagai proses astrogliosis sehingga GFAP diproduksi dan diekskresikan ke dalam aliran darah. Peningkatan kadar GFAP serum dengan sensitifitas 91% dan spesifisitas 97% menandakan reaktivitas sel astrosit dengan threshold cut off 0,29 ng/mL dan ditandai dengan memberatnya derajat defisit neurologis serta memperburuk luaran klinis pada pasien stroke iskemik akut. Glial Fibrillary Acidic Protein As Prognotic Marker In Acute Ischemic StrokeAbstractStroke is a neurological emergency that occurs suddenly and is the third leading cause of death in the world after heart disease and cancer. Ischemic stroke is the most common cause, namely 87% of all stroke cases. Biological markers are needed to describe the damage to brain nerve cells so that they can help clinicians to make a diagnosis of ischemic stroke. One of these markers is serum Glial Fibrillary Acidic Protein (GFAP) which is expressed by brain glial cells, namely astrocytes. Astrocytes are the most abundant glial cells in the Central Nervous System (CNS) which play an important role in maintaining physiological functions and maintaining brain homeostasis. Astrocytes are the earliest and most responsive cells to react when brain ischemia occurs. At the time of brain ischemia there will be hypertrophy of astrocyte cells which is referred to as astrogliosis process so that GFAP is produced and excreted into the bloodstream. Increasing GFAP levels with a sensitivity of 91% and a specificity of 97% indicates astrocyte cell reactivity with a threshold cut off of 0.29 ng/mL and is characterized by a worsening of the degree of neurological deficit and worsening of clinical outcomes in acute ischemic stroke patients.
EKSPLORASI PRAKTIK TEKNOLOGI INFORMASI MAHASISWA PPL PROGRAM STUDI PTIK UKSW DALAM SITUASI PANDEMI DAN SETELAH PANDEMI
Authors: Mansopu Mariana Isabella , Krismiyati Krismiyati 
Published: October 2023

Penelitian ini bertujuan untuk mengeksplorasi praktik teknologi mahasiswa yang melaksanakan Program Pengalaman Lapangan (PPL) dalam pembelajaran berbasis Teknologi Informasi dalam situasi pandemi dan setelah pandemi Covid-19. Metode yang digunakan adalah metode kualitatif dengan subjek penelitian adalah mahasiswa jurusan Pendidikan Teknik Informatika dan Komputer UKSW. Penelitian ini juga dilakukan untuk mengetahui bagaimana penggunaan dan permasalahan yang dihadapi mahasiswa PPL dalam penerapan Teknologi Informasi pada situasi dan kondisi pendidikan yang berbeda, dengan teknik pengumpulan data melalui wawancara menggunakan aplikasi WhatsApp. Hasil wawancara diolah dan disajikan dalam bentuk tabel informasi. Hasil yang diperoleh dari penelitian ini menunjukkan bahwa praktik penggunaan teknologi mahasiswa PPL saat dan setelah pandemi dinilai cukup baik dengan upaya yang dilakukan untuk terus dapat menyampaikan materi di tengah kendala dan situasi yang ada. Saat pandemi, sebanyak 80% informan mengaku terbantu dengan adanya teknologi-teknologi tersebut karena materi pembelajaran dapat diakses dimana saja tanpa melalui tatap muka. Sebanyak 10% informan merasa teknologi kurang mampu untuk menunjang pembelajaran disebabkan karena adanya gangguan koneksi internet yang menyebabkan materi pembelajaran yang disampaikan tidak berjalan baik. Dan sebanyak 10% informan merasa tidak terbantu karena siswa menjadi pasif. Sedangkan pada situasi setelah pandemi, seluruh informan atau 100% responden menyatakan terbantu dengan teknologi-teknologi yang ada.
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