bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute valve malfunction with thrombosed bioprosthetic valve after surgical aortic valve replacement
Authors: Moriuchi Hiroki , Koide Masaaki , Kunii Yoshifumi , Maeda Takuya , Shimbori Risa 
Published: September 2023

Key Clinical MessageAcute valve thrombosis after bioprosthetic aortic valve replacement even under anticoagulation therapy is extremely rare. Cardiac computed tomography is a powerful imaging tool to detect valve thrombosis, and surgery is necessary in case of unstable hemodynamics.
Type IV‐A choledochal cyst with choledocholithiasis in an adult female: A case report
Authors: Bhattarai Pratik , Timilsina Bishowdeep , Khanal Prasun 
Published: September 2023

AbstractA choledochal cyst is a rare congenital anomaly of the biliary system, characterized by bile duct cystic dilatation, typically affecting the common bile duct. Choledochal cysts are generally categorized using the Todani classification system. The typical symptoms are jaundice, abdominal masses, and recurrent abdominal pain. As most cases are diagnosed in children, adult presentations are uncommon and often associated with complications. A 22‐year‐old female patient complained of severe abdominal pain and vomiting for 5 days, with signs of jaundice. Her abdominal ultrasound revealed fusiform dilation of the extrahepatic common bile duct with multiple calculi in its distal‐most part. On CT cholangiogram of the abdomen, Type IV‐A Choledochal cyst with non‐obstructive choledocholithiasis was found. Although rare, choledochal cysts are a well‐known clinical entity. It is essential to diagnose and treat patients because they may develop complications. Cholecystectomy combined with Roux‐en‐Y hepaticojejunostomy is the preferred treatment for Type IV‐A choledochal cysts. Since choledochal cysts in adults are uncommon, early detection and treatment are essential to avoid serious complications. Ultrasonography (USG), Magnetic resonance cholangiopancreatography (MRCP), and Computed tomography (CT) can provide a diagnosis.
Delayed nasoseptal flap reuse in patients with revision endoscopic endonasal anterior skull base surgery
Authors: Lee Ye Hwan , Lee Seung Hoon , Seo Min Young 
Published: September 2023

Key Clinical MessageThe reuse of the nasoseptal flap represents a favorable option for skull base reconstruction in revision endoscopic anterior skull base surgery. This study demonstrated that a detached nasoseptal flap can remain viable for several days even if not immediately reattached.
Reduced Graphene Oxide Modulated FeSe/C Anode Materials for High‐Stable and Long‐Life Potassium‐Ion Batteries
Authors: Zhang Li , Liu Jie , Xiao Dengji , Chen Yuhui , Zhang Shuo , Yan Liting , Gu Xin , Zhao Xuebo 
Published: September 2023

AbstractReduced graphene oxide (rGO) has been demonstrated to effectively enhance the potassium storage performance of transition metal selenides due to its robust mechanical properties and high conductivity. However, the impact of rGO on the electrode‐electrolyte interface, a crucial factor in the electrochemical performance of potassium‐ion batteries (PIBs), requires further exploration. In this study, we synthesized a seamless architecture of rGO on FeSe/C nanocrystals (FeSe/C@rGO). Comparative analysis between FeSe/C and FeSe/C@rGO reveals that the rGO layer exhibits robust adsorption energies towards EC and DEC, inducing the formation of organic‐rich solid‐electrolyte interphase (SEI) without damage to the structural integrity. Furthermore, incorporating rGO triggers K+‐ions into the double electrode layer (EDL), markedly improving the transport of K+‐ions. As a PIB anode, FeSe/C@rGO exhibits a reversible capacity of 332 mAh g−1 at 200 mA g−1 after 300 cycles, along with excellent long‐term cycling stability, showcasing an ultralow decay rate of only 0.086 % per cycle after 1900 cycles at 1000 mA g−1.
Recent Developments of Dual Single‐Atom Catalysts for Nitrogen Reduction Reaction
Authors: Liang Mengfang , Shao Xiaodong , Lee Hyoyoung 
Published: September 2023

AbstractAmmonia is vital for fertilizer production, hydrogen storage, and alternative fuels. The conventional Haber‐Bosch process for ammonia production is energy‐intensive and environmentally harmful. Designing environmentally friendly and low‐energy consumption strategies for electrocatalytic N2 reduction reaction (ENRR) in mild conditions is meaningful. Single‐atom catalysts (SACs) have been studied extensively for NRR due to their high atomic utilization and unique electronic structure but are limited by their poor faradic efficiency and low ammonia formation yield. Dual single‐atom catalysts (DSACs) have recently emerged as a promising solution for the effective activation of molecular N2, providing diverse active sites and synergistic interactions between adjacent atoms. In this review, we summarize the latest advances in metal DSACs for electrochemical ENRR based on both theoretical calculations and experimental studies, including aspects such as their variety, coordination, support, N2 adsorption and activity mechanisms, the characterization of NRR and electrochemical cell Configuration. We also address challenges and prospects in this rapidly evolving field, providing a comprehensive overview of DSACs for ENRR.
Decarboxylative Amination with Nitroarenes via Synergistic Catalysis†
Authors: Ding Meiling , Zhou Sitian , Yao Shunruo , Zhu Chengjian , Li Weipeng , Xie Jin 
Published: September 2023

Comprehensive SummaryIn this paper, we have developed a decarboxylative amination of carboxylic acids with nitroarenes for the synthesis of secondary amines. The protocol is performed at mild conditions without the use of noble metals as catalysts. A wide range of structurally diverse secondary amines could be obtained in good yields (up to 94%) with good functional group tolerance. This transformation shows good to excellent selectivity, avoiding the generation of over alkylated byproducts.
Top advances of the year: Myeloproliferative neoplasms
Authors: Bhave Rupali R. , Mesa Ruben , Grunwald Michael R. 
Published: September 2023

AbstractThe rapid pace of drug development in hematology has led to multiple approvals for myelofibrosis (MF) and polycythemia vera (PV) in recent years. Moreover, there are many innovative agents and combinations being explored for myeloproliferative neoplasms (MPNs). In the past year, there have been several advances in MF, PV, and essential thrombocythemia. In MF, investigational approaches are focusing on strategies to optimize inhibition of signal transduction (including JAK inhibition), modify epigenetics, enhance apoptosis, target DNA replication, transform host immunity, and/or alter the tumor microenvironment. In PV, ropeginterferon alfa‐2b has been introduced to the market in the United States, and data continue to accumulate to support the safety and efficacy of this treatment. Hepcidin mimesis is also emerging as a novel way to treat erythrocytosis. In essential thrombocythemia, ropeginterferon alfa‐2b is being evaluated, as are therapies to modify epigenetics and inhibit CALR. The enhanced focus on MPNs brings hope that our field can improve morbidity and mortality in this group of diseases.
Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas
Authors: Kummar Shivaani , Shen Lin , Hong David S. , McDermott Ray , Keedy Vicki L. , Casanova Michela , Demetri George D. , Dowlati Afshin , Melcón Soledad Gallego , Lassen Ulrik N. , Leyvraz Serge , Liu Tianshu , Moreno Victor , Patel Jyoti , Patil Tejas , Mallick Atrayee Basu , Sousa Nuno , Tahara Makoto , Ziegler David S. , Norenberg Ricarda , Arvis Pierre , Brega Nicoletta , Drilon Alexander , Tan Daniel S. W. 
Published: September 2023

AbstractBackgroundLarotrectinib, a first‐in‐class, highly selective tropomyosin receptor kinase (TRK) inhibitor, has demonstrated efficacy in adult and pediatric patients with various solid tumors harboring NTRK gene fusions. This subset analysis focuses on the efficacy and safety of larotrectinib in an expanded cohort of adult patients with TRK fusion sarcomas.MethodsPatients (≥18 years old) with sarcomas harboring NTRK gene fusions were identified from three clinical trials. Patients received larotrectinib 100 mg orally twice daily. Response was investigator‐assessed per RECIST v1.1. Data cutoff was July 20, 2021.ResultsAt the data cutoff, 36 adult patients with TRK fusion sarcomas had initiated larotrectinib therapy: two (6%) patients had bone sarcomas, four (11%) had gastrointestinal stromal tumors, and 30 (83%) had soft tissue sarcomas. All patients were evaluable for response and demonstrated an objective response rate of 58% (95% confidence interval, 41–74). Patients responded well to larotrectinib regardless of number of prior lines of therapy. Adverse events (AEs) were mostly grade 1/2. Grade 3 treatment‐emergent AEs (TEAEs) occurred in 15 (42%) patients. There were no grade 4 TEAEs. Two grade 5 TEAEs were reported, neither of which were considered related to larotrectinib. Four (11%) patients permanently discontinued treatment due to TEAEs.ConclusionsLarotrectinib demonstrated robust and durable responses, extended survival benefit, and a favorable safety profile in adult patients with TRK fusion sarcomas with longer follow‐up. These results continue to demonstrate that testing for NTRK gene fusions should be incorporated into the clinical management of adult patients with various types of sarcomas.Plain Language Summary

Tropomyosin receptor kinase (TRK) fusion proteins result from translocations involving the NTRK gene and cause cancer in a range of tumor types.
Larotrectinib is an agent that specifically targets TRK fusion proteins and is approved for the treatment of patients with TRK fusion cancer.
This study looked at how well larotrectinib worked in adult patients with sarcomas caused by TRK fusion proteins.
Over half of patients had a durable response to larotrectinib, with no unexpected side effects.
These results show that larotrectinib is safe and effective in adult patients with TRK fusion sarcomas.
Outcome of Philadelphia chromosome‐positive chronic myeloid leukemia in the United States since the introduction of imatinib therapy—The Surveillance, Epidemiology, and End Results database, 2000–2019
Authors: Sasaki Koji , Haddad Fadi G. , Short Nicholas J. , Jain Nitin , Issa Ghayas , Jabbour Elias , Kantarjian Hagop 
Published: September 2023

AbstractBackgroundSince the introduction of BCR::ABL1 tyrosine kinase inhibitors (TKIs) in 2000, the treatment of Philadelphia chromosome (Ph)‐positive chronic myeloid leukemia (CML) has improved significantly.MethodsThis study aimed to evaluate Ph‐positive CML outcomes in the TKI therapy era, considering factors like age, ethnicity, and income. Using the Surveillance, Epidemiology, and End Results (SEER) database, 2857 patients with Ph‐positive CML diagnosed from 2000 to 2019 were analyzed.ResultsThe overall 5‐year survival rates in Ph‐positive CML increased to above 80%, compared with pre‐TKIs historical data reporting 5‐year overall survival (OS) rates of less than 50%. The 5‐year OS rate was 73% for patients diagnosed in 2000–2004, 82% in 2005–2009, and 78% in 2010–2014; the 4‐year OS rate was 83% in 2015–2019. The 5‐year OS rate for younger patients (<60 years old) was 88% in 2000–2009 and 90% in 2010–2019 (p value .426). In older patients (60+ years old), the 5‐year OS rates were 64% and 65%, respectively (p value, .303). Lower household income was associated with inferior survival across the 2000–2019. These results are inferior to European studies where TKIs are universally available and affordable, and relative OS in CML is similar to age‐matched normal populations.ConclusionsAlthough the outcome of Ph‐positive CML has improved significantly since 2000, the SEER data still shows differences in outcomes among patient subsets, some anticipated (worse OS in older patients accounted by the relative OS), but others that suggest less than universal access and affordability of this therapy (among poorer patients) in the United States.
Rapid on‐site evaluation (ROSE) of image‐guided FNA specimens improves subsequent core biopsy adequacy in clinical trial patients: The impact of preanalytical factors and its correlation with survival
Authors: Graham Ashleigh J. , Robinson Mahalia T. , Kahler Jessica , Azadi Javad R. , Maleki Zahra 
Published: September 2023

AbstractBackgroundSufficient tumor collection has become of utmost importance in therapeutic experimental protocols. Rapid on‐site evaluation (ROSE) ensures adequate sampling for quantification of biomarkers, molecular analyses, and other ancillary studies. The objectives of this study were to evaluate the role of ROSE in trial‐associated fine‐needle aspiration (FNA) and to analyze predictors of adequacy and cumulative survival from in‐house FNA cases used in clinical trials.MethodsClinical trial FNA biopsies performed at a large academic institution were analyzed over 10 months using a comprehensive chart review of the electronic medical records. SPSS version 28 was used for statistical analysis.ResultsThree hundred twenty‐five FNAs were collected for 57 clinical trials. In total, 225 individual patients had an average of 1.4 FNA procedures each as a result of a multidepartmental collaborative effort. ROSE was performed for all patients, and adequacy was evaluated by cytotechnologists. Seventy‐eight percent of samples were considered adequate, 14% were considered less than optimal, and 8% were considered inadequate, with the latter two categories designated together as less than adequate. The imaging modalities were mainly ultrasound‐guided (n = 267; 82%) and computed tomography‐guided (n = 58; 18%). There was a statistically significant association between adequate sampling and ultrasound‐guided biopsies (83%) compared with computed tomography‐guided biopsies (59%; p < .01). The effect of body mass index (BMI) on mortality was also a significant finding. The authors observed a survival benefit in patients who had elevated BMIs (range, 25.0–34.9 kg/m2) compared with those who were underweight (BMI, <18.5 kg/m2) or class III obese (BMI, >35.0 kg/m2; p < .01). Therefore, the best predictors of adequacy and mortality were imaging modality and BMI, respectively.ConclusionsUltrasound‐guided modalities are recommended for obtaining adequate FNA sampling for clinical trials. In addition, patients with cancer who had slightly elevated BMIs (25.0–34.0 kg/m2) had increased overall survival in this cohort.
Prevalence and risk factors of peri‐implant diseases at patient‐level: A cross‐sectional study in Syria
Authors: Aljalloud Asmaa A. A. , Dayoub Suleiman , Tolibah Yasser Alsayed 
Published: September 2023

AbstractObjectivesThis research aims to assess the prevalence of peri‐implant diseases and to analyze variables of the probable risk at the patient level associated with the occurrence of peri‐implant diseases in Syrian patients.Materials and MethodsA cross‐sectional study has been carried out on 142 patients with 380 dental implants placed between 2015 and 2021. Patients were invited by phone to return to Damascus University's Periodontology Department for clinical and radiological examination. A descriptive statistical analysis was implemented for the prevalence of peri‐implant diseases at the level of the patients. Also, the peri‐implant diseases' factors of risk were determined by the multivariate analytical model.ResultsThe prevalence rate of peri‐implant mucositis and peri‐implantitis in patients was 58.5% and 25.4%, respectively. Peri‐implant disease is associated with multivariate risk indices, gender female (peri‐implant mucositis [OR = 0.269; 95% CI: 0.131−0.552] and peri‐implantitis [OR = 0.561; 95% CI: 0.561−0.216]), diabetes (peri‐implant mucositis [OR = 3.4; 95% CI: 1.73−12.73]), periodontitis (peri‐implant mucositis [OR = 2.409; 95% CI: 1.760−2.613], peri‐implantitis [OR = 10.445; 95% CI: 4.097−26.629]).ConclusionsPeri‐implant diseases are common in the Syrian community. Several patient‐level variables (gender female, diabetes, and periodontitis) are associated with peri‐implant disease.
Third‐order filtering crossover using dual‐mode resonator for high‐isolated channels
Authors: Qiu Lei‐Lei , Guo Yiming , Zhu Lei , Ouyang Zhao‐An , Huang Shengxiang , Deng Lianwen 
Published: September 2023

SummaryThis paper proposes a high‐selective crossover with a third‐order filtering characteristic, high passband isolation, and multiple controllable transmission zeros based on a coupled topology using single‐ and dual‐mode resonators. By virtue of the odd‐ and even‐mode feature of the stub‐loaded dual‐mode ring resonator, not only can the two resonant modes for different passbands be relatively independently controlled, but also better isolation can be achieved. With a single‐mode resonator and stub‐loaded dual‐mode resonant coupling topology, the resultant crossover can perform third‐order filtering performance in two distinct passbands/channels and generate several transmission zeros outside the desired bands to improve the isolation between the passbands. Experimental results demonstrate that, compared with conventional works, the filtering order of the proposed crossover is promoted and its passband isolation can be significantly improved by about 8 dB. The proposed work may facilitate its widespread applications in high‐performance multichannel integrated microwave systems for avoiding interference between multiple intersecting signal paths.
Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos
Authors: Shinozuka Takuma , Aoki Motoko , Hatakeyama Yudai , Sasai Noriaki , Okamoto Hitoshi , Takada Shinji 
Published: September 2023

AbstractBackgroundR‐spondins (Rspos) are secreted proteins that modulate Wnt/β‐catenin signaling. At the early stages of spinal cord development, Wnts (Wnt1, Wnt3a) and Rspos (Rspo1, Rspo3) are co‐expressed in the roof plate, suggesting that Rspos are involved in development of dorsal spinal cord and neural crest cells in cooperation with Wnt ligands.ResultsHere, we found that Rspo1 and Rspo3, as well as Wnt1 and Wnt3a, maintained roof‐plate‐specific expression until late embryonic stages. Rspo1‐ and Rspo3‐double‐knock‐out (dKO) embryos partially exhibited the phenotype of Wnt1 and Wnt3a dKO embryos. While the number of Ngn2‐positive sensory lineage neural crest cells is reduced in Rspo‐dKO embryos, development of dorsal spinal cord, including its size and dorso‐ventral patterning in early development, elongation of the roof plate, and proliferation of ependymal cells, proceeded normally. Consistent with these slight defects, Wnt/β‐catenin signaling was not obviously changed in developing spinal cord of dKO embryos.ConclusionsOur results show that Rspo1 and Rspo3 are dispensable for most developmental processes involving roof plate‐derived Wnt ligands, except for specification of a subtype of neural crest cells. Thus, Rspos may modulate Wnt/β‐catenin signaling in a context‐dependent manner.
Age‐specific reproduction in female Steller sea lions in Southeast Alaska
Authors: Hastings Kelly K. , Jemison Lauri A. , Pendleton Grey W. , Johnson Devin S. , Gelatt Thomas S. 
Published: September 2023

AbstractAge‐, region‐, and year‐specific estimates of reproduction are needed for monitoring wildlife populations during periods of ecosystem change. Population dynamics of Steller sea lions (Eumetopias jubatus) in Southeast Alaska varied regionally (with high population growth and survival in the north vs. the south) and annually (with reduced adult female survival observed following a severe marine heatwave event), but reproductive performance is currently unknown. We used mark‐resighting data from 1006 Steller sea lion females marked as pups at ~3 weeks of age from 1994 to 1995 and from 2001 to 2005 and resighted from 2002 to 2019 (to a maximum age of 25) to examine age‐, region‐, and year‐specific reproduction. In the north versus the south, age of first reproduction was earlier (beginning at age 4 vs. age 5, respectively) but annual birth probabilities of parous females were reduced by 0.05. In an average year pre‐heatwave, the proportion of females with pup at the end of the pupping season peaked at ages 12–13 with ~0.60/0.65 (north/south) with pup, ~0.30/0.25 with juvenile, and ~0.10 (both regions) without a dependent. In both regions, reproductive senescence was gradual after age 12: ~0.40, 0.40, and 0.20 of females were in these reproductive states, respectively, by age 20. Correcting for neonatal mortality, true birth probabilities at peak ages were 0.66/0.72 (north/south). No cost of reproduction on female survival was detected, but pup production remained lower (−0.06) after the heatwave event, which if sustained could result in population decline in the south. Reduced pup production and greater retention of juveniles during periods of poor prey conditions may be an important strategy for Steller sea lions in Southeast Alaska, where fine‐tuning reproduction based on nutritional status may improve the lifetime probability of producing pups under good conditions in a variable and less productive environment.
The High–Low Arctic boundary: How is it determined and where is it located?
Authors: Ermokhina Ksenia A. , Terskaia Anna I. , Ivleva Tatiana Yu. , Dudov Sergey V. , Zemlianskii Vitalii А. , Telyatnikov Michael Yu. , Khitun Olga V. , Troeva Elena I. , Koroleva Natalia E. , Abdulmanova Svetlana Yu. 
Published: September 2023

AbstractGeobotanical subdivision of landcover is a baseline for many studies. The High–Low Arctic boundary is considered to be of fundamental natural importance. The wide application of different delimitation schemes in various ecological studies and climatic scenarios raises the following questions: (i) What are the common criteria to define the High and Low Arctic? (ii) Could human impact significantly change the distribution of the delimitation criteria? (iii) Is the widely accepted temperature criterion still relevant given ongoing climate change? and (iv) Could we locate the High–Low Arctic boundary by mapping these criteria derived from modern open remote sensing and climatic data? Researchers rely on common criteria for geobotanical delimitation of the Arctic. Unified circumpolar criteria are based on the structure of vegetation cover and climate, while regional specifics are reflected in the floral composition. However, the published delimitation schemes vary greatly. The disagreement in the location of geobotanical boundaries across the studies manifests in poorly comparable results. While maintaining the common principles of geobotanical subdivision, we derived the boundary between the High and Low Arctic using the most up‐to‐date field data and modern techniques: species distribution modeling, radar, thermal and optical satellite imagery processing, and climatic data analysis. The position of the High–Low Arctic boundary in Western Siberia was clarified and mapped. The new boundary is located 50–100 km further north compared to all the previously presented ones. Long‐term anthropogenic press contributes to a change in the vegetation structure but does not noticeably affect key species ranges. A previously specified climatic criterion for the High–Low Arctic boundary accepted in scientific literature has not coincided with the boundary in Western Siberia for over 70 years. The High–Low Arctic boundary is distinctly reflected in biodiversity distribution. The presented approach is appropriate for accurate mapping of the High–Low Arctic boundary in the circumpolar extent.