bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTIVENESS OF APPLYING ORIGINAL METHOD OF BREATHING EXERCISES, INCLUDING TECHNIQUES FOR MOBILIZING DIAPHRAGMAL BREATHING IN COMPLEX EARLY MEDICAL REHABILITATION OF PATIENTS WHO HAVE UNDERGONE CORONARY BYPASS GRAFT
Authors: Pomeshkina Svetlana A. , Arhipova Natalia V. , Lebedeva Natalia B. , Argunova Yulia A. , Barbarash Olga L. 
Published: February 2024

Highlights In the physical rehabilitation of patients after coronary artery bypass surgery (CABG), special attention has recently been paid to respiratory rehabilitation. The article presents the results of studies demonstrating that a course of respiratory coordination training was associated with a decrease in the incidence of hydrothorax, improved blood oxygen saturation, increased exercise tolerance and muscle strength by reducing diaphragm dysfunction and increasing respiratory muscle strength in patients in the postoperative period. AbstractAim. To analyze the clinical effectiveness of a new method of breathing exercises developed for improving breathing control in complex early rehabilitation of patients who underwent CABG.Methods. The study involved 73 patients with coronary artery disease (CAD) who underwent CABG at the Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases” (Kemerovo, Russia) in 2021. During the inpatient rehabilitation, patients were randomized into two groups comparable in anamnestic and baseline clinical and functional indicators: the experimental group (38 patients) had individual breathing exercises as a part of respiratory gymnastics (with different types of exercises), and the control group (35 patients) underwent conventional exercise training.Results. Initially, there were no statistically significant differences between the groups. After 14 days the number of patients in the main group with signs of hydrothorax was significantly lower compared with the control group: 7 (18.4%) vs 11 (31.4%), respectively, p = 0.001. The ultrasound examination of the pleural space revealed the same pattern - hydrothorax was less pronounced in the main group compared with the control group: 0.9 [0.5; 1.5] vs 1.7 [0.6; 2.5] mL, p = 0.049. Analysis of oxygen saturation (SpO₂,%), reflecting the functional status of the oxygen transport system, showed higher blood oxygen saturation rates in the main group compared with the control group: 98 [96; 99] vs 95.2[94; 97]%, p = 0.04, respectively. At the same time, the exercise tolerance (ET) estimated with bicycle ergometry was comparable at baseline in both groups, and at the end of the inpatient rehabilitation ET in the main group was significantly higher than in the control group with conventional exercise training: 74. 9 [50; 100] vs 55.1[25; 75] W, p = 0.005, respectively.Conclusion. Respiratory gymnastics facilitates cardiac and respiratory rehabilitation mainly by improving the coordination of respiratory muscles and preparing them for respiratory gymnastics within short period of early inpatient rehabilitation.
THETA CURRENT SOURCES DENSITY CHANGES IN CARDIAC SURGERY PATIENTS COGNITIVE AFTER MULTITASKING TRAINING
Authors: Tarasova Irina V. , Kupriyanova Darya S. , Syrova Irina D. , Sosnina Anastasia S. , Trubnikova Olga A. 
Published: February 2024

HighlightsWe estimated theta current sources density changes in patients who received cognitive multitasking training in the early postoperative period of cardiac surgery.Patients with cognitive multitasking training had a significantly lower theta current source density (t<–3.89; p<0.002) before surgery compared to baseline. The strongest differences were localized in Brodmann areas 7, 19 and 31 which related to the structures of the parieto-occipital lobes of the brain, cuneus and precuneus. AbstractAim. The effect of cognitive recovery techniques on brain activity remains a significant issue in modern health care. The aim of this study was to estimate theta current sources density changes using standardized low resolution electromagnetic tomography – sLORETA – (standardized low resolution brain electromagnetic tomography) in patients who have received cognitive multitasking training (CMT) in the postoperative period of coronary artery bypass grafting (CABG).Methods. The study included 30 patients aged between 45 and 75 years who underwent routine CABG. Clinical and neurophysiological examinations were carried out 2–3 days before surgery and 11–12 days after CABG. The cognitive training started 3–4 days after CABG and lasted until discharge and consisted of a motor task - a keypress in response to an object appearing on the screen and three consecutive cognitive tasks (counting backwards, verbal fluency and unusual use of an ordinary object).Results. Patients with CMT had lower theta current source density (t<–3.89; p<0.002) before CABG as compared to postoperative data, the most significant differences were noted in parieto-occipital lobes of the brain, cuneus and precuneus (Brodmann areas 7, 19 and 31).Conclusion. The results of our research contribute to a better understanding of the pathogenetic mechanisms underlying postoperative cognitive impairments in cardiac surgery patients.
COMPARATIVE ANALYSIS OF RECEPTIVE AND EXPRESSIVE LANGUAGE INDICATORS IN PRIMARY SCHOOLCHILDREN WITH SEPTAL CONGENITAL HEART DEFECTS
Authors: Rumiantseva Aleksandra A. , Kameneva Veronika A. 
Published: February 2024

Highlights In recent years, congenital heart defects (CHD) have remained the most prevalent diseases in young children. Opinions on the health of children who have undergone cardiac surgery vary: for example, there are data in the literature indicating that speech disorders following cardiac surgery are present in 56% of cases, whereas cognitive disorders are present in 21% of cases. Aim. To study the level of development of receptive and expressive language in primary schoolchildren with septal congenital heart defects before surgical correction. Methods. The prospective study of children (n = 90) with septal congenital heart defects (atrium septal defect, n = 75; ventricle septal defect n = 15) before surgical correction was conducted at the Scientific Research Institute of Complex Issues of Cardiovascular Diseases (Kemerovo). The anamnesis, clinical symptoms, hemodynamics and the level of speech development (receptive and expressive language) were studied.Results. In children with septal heart defects, speech disorders were noted in 82% of cases: 56% of children had common speech disorders, 26% had delayed speech development. Expressive language skills of these children can be often characterized by delayed development, which manifests in the form of articulation disorder, difficulties with grammar syntax and morphology, and pronunciation disorders. There were no statistically significant differences between the level of expressive language and the type of CHD (p = 0.125).Conclusion. Even in the absence of intracardiac hemodynamic disorders in children with septal CHD, detected neurodevelopmental delays at the preoperative period necessitates the implementation of the interdisciplinary approach in the management of children with such pathology.
EXPRESSION OF GENES OF BIOMOLECULES ASSOCIATED WITH THE ETIOPATHOGENESIS OF ATHEROSCLEROSIS IN ATHEROSCLEROTIC PLAQUES OF CORONARY ARTERIES
Authors: Semaev Sergey S. , Shakhtshneider Elena V. , Ivanoshchuk Dinara E. , Fishman Veniamin S. , Polonskaya Yana V. , Kashtanova Elena V. , Chernyavskiy Alexander M. , Murashov Ivan S. , Volkov Alexander M. , Ragino Yulia I. 
Published: February 2024

HighlightsThe study showed differences in the expression of a number of genes in atherosclerotic plaques of different types in patients with coronary atherosclerosis. The obtained data can become the basis for the development of test systems in order to determine the dynamics of the atherosclerotic process and detect signs of destabilization of the atherosclerotic plaque as early as possible. Aim. To study the differential expression of genes encoding molecules associated with the etiopathogenesis of atherosclerosis by the method of genome-wide RNA sequencing in stable atherosclerotic plaque of fibrous type and unstable atherosclerotic plaque of dystopic-necrotic type.Methods. The study was performed on samples of atherosclerotic plaques of patients with coronary atherosclerosis without acute coronary syndrome with stable angina pectoris of functional class II–IV (FC) at the age of 45-65 years. Tissue sampling of atherosclerotic plaques was performed intraoperatively in the presence of indications. Genome-wide RNA sequencing was performed using Illumina’s TruSeq RNA Sample Preparation Kit (Illumina, USA).Results. An increase in the level of gene expression in stable atherosclerotic plaques was noted for A2M, ADAMTS13, CSF3, CX3CL1, CXCL1, FGF2, GDF15, ICAM1, IL1A, IL1B, IL6, IL10, PDGFA, PTX3. There was an eightfold statistically significant increase in the level of CFD, CXCL16, FABP4, FLT3, IFNG, IL7, IL15, SELL, TGFA, THBD, TNNT1, VCAM1 and VEGFA gene expression (p<0,001) in unstable atherosclerotic plaques of dystrophic-necrotic type.Conclusion. The study showed differences in the expression of a number of genes in atherosclerotic plaques of different types in patients with coronary atherosclerosis. The obtained data can become the basis for the development of test systems in order to determine the dynamics of the atherosclerotic process and detect signs of destabilization of the atherosclerotic plaque as early as possible.
BIOCOMPATIBLE ELASTIC POLYMER NANOCOMPOSITES BASED ON MULTIWALLED CARBON NANOTUBES FOR APPLICATION IN CARDIOVASCULAR SURGERY
Authors: Rezvova Maria A. , Nikishau Pavel A. , Kostyuk Sergey V. , Makarevich Miroslav I. , Onishchenko Pavel S. , Klyshnikov Kirill Y. , Glushkova Tatyana V. , Kostyunin Alexander E. , Ovcharenko Evgeny A. 
Published: February 2024

HighlightsThe incorporation of multi-walled carbon nanotubes into the structure of the poly(styrene-block-isobutylene-block-styrene) polymer matrix leads to an increase in the tensile strength and Young's modulus of the nanocomposites. The resulting nanocomposites retain high biocompatibility and can be used as elements of implanted cardiovascular products. AbstractAim. To synthesize and modify poly(styrene-block-isobutylene-block-styrene) (SIBS) with two types of multi-walled carbon nanotubes (MWCNTs) in different concentrations to improve its mechanical properties.Methods. SIBS was synthesized by controlled cationic polymerization. Polymer nanocomposites were prepared using ultrasonic dispersion followed by casting films from a polymer solution. The resulting nanocomposite films were subjected to mechanical tests under uniaxial tensile conditions. Tensile strength, elastic-strain properties, and plastic deformation under cyclic loading were assessed. The structure of the nanocomposites was analyzed by scanning electron microscopy. The hydrophilicity of the surface of the materials was studied by measuring the contact angle with water. The cytotoxicity of the resulting polymer films was assessed by the viability and metabolic activity of endothelial cells cultured on the surface of the nanocomposites.Results. Polymer nanocomposites with a uniform distribution of MWCNTs in the polymer matrix were obtained. SIBS films modified with 1% MWCNTs with a diameter of 50–90 nm showed an increase in tensile strength by 16.4% compared to SIBS polymer. Increasing the concentration of MWCNTs to 8% led to a decrease in the strength of polymer materials by 19,6%. The inclusion of nanoparticles into the polymer matrix significantly increased the Young's modulus of the studied polymers with a MWCNT content above 4%. With an increase in the content of MWCNTs in the nanocomposites, an increase in hydrophilicity was also observed, while the cytotoxicity of the samples towards endothelial cells was not noted.Conclusion. Nanocomposites based on SIBS and MWCNTs, due to their high strength and biocompatibility, can become a promising material for the development of various medical products, in particular prosthetic heart valves.
Toward the Rapid Seismic Assessment of Landslides in Coastal Alaska
Authors: Karasözen Ezgi , West Michael E. 
Published: February 2024

Abstract
As glaciers retreat, landslide-driven tsunamis pose mounting threats across the high latitudes. The recent landslide tsunamis in Alaska and Greenland have spurred efforts to forecast and monitor these events. We use nine large landslides spanning southern Alaska to test an approach for rapid detection and characterization. We use long-period seismograms recorded within three minutes of the start of a landslide to estimate the location and approximate volume. In the presence of good seismic network coverage, location errors are no more than a few kilometers, and detection limits are well below 1  Mm3. The combination of detection time, location, and size provides the ability to rapidly determine whether a landslide occurred close to open water and, if so, its tsunamigenic potential. Our approach is rapid enough to support National Oceanic and Atmospheric Administration (NOAA)’s five-minute tsunami warning goal. The historical analysis we present provides the foundation and parameter tuning for a prototype system that is now providing real-time detections.
Acerca de la naturaleza y de la patria del Padre Sarmiento
Authors: Santos Puerto José 
Published: February 2024

Unos meses atrás X.L. Méndez Ferrín dedicó dos de sus Espellos, y algunas líneas de un tercero, a discutir un trabajo mío sobre la procedencia del Gran Gallego, publicado en Sarmiento. Anuario de Historia da Educación. A los pocos días de salir el último artículo yo envié un escrito de aclaraciones al periódico, y por medio de éste al autor. Nada contestaron, ni tampoco publicaron mi escrito, por lo que un par de semanas después lo remití de nuevo. Tampoco tuve respuesta, ni del periódico ni de Méndez Ferrín. Esta es una versión aligerada de aquel escrito, que remitida de nuevo por si el Faro de Vigo consideraba una buena fecha el día 9 de marzo, fecha del nacimiento de Martín Sarmiento, tampoco fue atendida.
Exploring Perspectives on Cancer Screening in People Aged 30-70: A Comparative Study of Those With and Without Type 2 Diabetes
Authors: GÜR Yunus , TURAL Egemen , DAYAN Akın 
Published: February 2024

Objective: The aim of the study was to assess attitudes and behaviors related to cancer screening using an attitude scale for cancer screening among individuals aged 30-70 with and without type 2 diabetes mellitus.
Methods: This prospective case-control study was conducted from March to May 2023 at a single center. A total of 197 participants, including 67 patients with type 2 diabetes mellitus and 130 participants without type 2 diabetes mellitus aged 30-70, were enrolled using simple random sampling. For the assessment, a sociodemographic form prepared through a literature review and the attitude scale for cancer screening were used. A statistical significance level of p
Assessing the Accuracy and Reliability of AI-Generated Responses to Patient Questions Regarding Spine Surgery
Authors: Kasthuri Viknesh S. , Glueck Jacob , Pham Han , Daher Mohammad , Balmaceno-Criss Mariah , McDonald Christopher L. , Diebo Bassel G. , Daniels Alan H. 
Published: February 2024

Background:
In today’s digital age, patients increasingly rely on online search engines for medical information. The integration of large language models such as GPT-4 into search engines such as Bing raises concerns over the potential transmission of misinformation when patients search for information online regarding spine surgery.

Methods:
SearchResponse.io, a database that archives People Also Ask (PAA) data from Google, was utilized to determine the most popular patient questions regarding 4 specific spine surgery topics: anterior cervical discectomy and fusion, lumbar fusion, laminectomy, and spinal deformity. Bing’s responses to these questions, along with the cited sources, were recorded for analysis. Two fellowship-trained spine surgeons assessed the accuracy of the answers on a 6-point scale and the completeness of the answers on a 3-point scale. Inaccurate answers were re-queried 2 weeks later. Cited sources were categorized and evaluated against Journal of the American Medical Association (JAMA) benchmark criteria. Interrater reliability was measured with use of the kappa statistic. A linear regression analysis was utilized to explore the relationship between answer accuracy and the type of source, number of sources, and mean JAMA benchmark score.

Results:
Bing’s responses to 71 PAA questions were analyzed. The average completeness score was 2.03 (standard deviation [SD], 0.36), and the average accuracy score was 4.49 (SD, 1.10). Among the question topics, spinal deformity had the lowest mean completeness score. Re-querying the questions that initially had answers with low accuracy scores resulted in responses with improved accuracy. Among the cited sources, commercial sources were the most prevalent. The JAMA benchmark score across all sources averaged 2.63. Government sources had the highest mean benchmark score (3.30), whereas social media had the lowest (1.75).

Conclusions:
Bing’s answers were generally accurate and adequately complete, with incorrect responses rectified upon re-querying. The plurality of information was sourced from commercial websites. The type of source, number of sources, and mean JAMA benchmark score were not significantly correlated with answer accuracy. These findings underscore the importance of ongoing evaluation and improvement of large language models to ensure reliable and informative results for patients seeking information regarding spine surgery online amid the integration of these models in the search experience.
New CMS Policy on the Mandatory Collection of Patient-Reported Outcome Measures for Total Hip and Knee Arthroplasty by 2027
Authors: Pasqualini Ignacio , Piuzzi Nicolas S. 
Published: February 2024

Abstract:
The Centers for Medicare & Medicaid Services (CMS) has finalized a landmark national policy to standardize and expand the collection and reporting of patient-reported outcome measures (PROMs) following total hip arthroplasty (THA) and total knee arthroplasty (TKA). This policy will be rolled out through phased implementation, beginning with voluntary reporting starting in 2023 and transitioning to mandatory reporting starting in 2025, which will be tied to hospital payment determinations in fiscal year 2028. The overarching goal of this policy is to gather meaningful pre- and postoperative PROM data directly from patients to enhance clinical care, shared decision-making, and quality measurement for these common elective procedures. This national initiative underscores the value of incorporating patient perspectives and priorities into assessments of surgical care quality. For orthopaedic surgeons and hospitals, participating in the initial voluntary reporting period provides an opportunity to integrate PROM collection into clinical workflows and to leverage these data to improve patient care. The achievement of robust PROM response rates and a strong performance on the underlying THA/TKA Patient-Reported Outcome-Based Performance Measure may have increasing relevance as payment models shift toward value-based care. The aim of the present forum was to provide an in-depth review of this new CMS policy and key details regarding required PROM instruments, data-collection time frames, and other specifications that surgical teams should understand as they prepare for implementation. The goal was to equip orthopaedic surgeons with actionable information as they embark on this new era of national PROM collection and reporting.
Assessing the landscape of clinical trials involving bioprinting: a scoping review protocol
Authors: Briones Yumi L. , Tiangco Narra Maria J. , Crisostomo Isabel C. , Pascua Beatrice Paula G. , Casiguran Samantha Louise , Remenyi Roland 
Published: February 2024

Abstract
Bioprinting is a tissue engineering method with promising clinical applications. This scoping review protocol aims to assess the past and present landscape of clinical trials involving bioprinting. In this protocol, the term “bioprint” and its variants will be searched in five clinical trial databases and two primary registries. Results will then undergo dual independent review to determine the final inclusion list. Finally, data will be synthesized narratively. Our protocol is designed to maximize search coverage while minimizing search time by utilizing databases covering multiple international primary registries. Ultimately, we aim to provide a framework for monitoring developments and identifying specific research questions within the rapidly evolving field of clinical bioprinting over time.
Study on the Awareness of Cigarette Butt as a Potential Environmental Hazard
Authors: Thakur Meenakshi , Bhardwaj Sushma , Singh Jyotsna , Iqbal Hiba 
Published: February 2024

Abstract
Cigarette butt pollution is a global environmental concern with profound health and ecological ramifications. This study addresses the pressing need for coordinated efforts involving the public, manufacturers, lawmakers, and citizens to manage and mitigate the detrimental consequences of this pervasive pollutant. The research focuses on the younger generation's awareness of this issue. The survey encompassed 454 respondents, primarily comprising individuals aged 13–19 years (60%), with a substantial representation of females (64%). Encouragingly, an overwhelming majority (97%) recognized cigarette butts as pollutants, irrespective of gender, highlighting substantial public awareness. Notably, respondents reported encountering cigarette debris in public places, often witnessing improper disposal, such as in drains, contributing to water pollution. While respondents exhibited reasonable awareness of the hazards linked to cigarette butts, including fires and harm to wildlife, only 42% were aware of their role in ocean pollution, suggesting a knowledge gap. Notably, despite awareness, improper disposal remains a concern, indicating societal insensitivity. This underscores the need for enhanced public education. The study concludes with recommendations, including awareness campaigns and biodegradable filters, to address cigarette butt pollution. Comprehensive interventions and legislation against careless disposal are essential. This research aims to stimulate further interdisciplinary exploration and draw policymakers' attention to reducing this potential pollutant's impact through sustainable methods.