bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term functional outcome and quality of life 2.5 years after thrombolysis in acute ischemic stroke
Authors: Schäbitz Marie , Möller Leona , Friedrich Anja , Klein Nele , Kitsiou Alkisti , Greeve Isabell , Gerstner Anja , Wulff Leonard , Schäbitz Wolf-Rüdiger , Timmermann Lars , Rogalewski Andreas 
Published: November 2023

Abstract
Background
Evaluation of outcome after stroke is largely based on assessment of gross function 3 months after stroke onset using scales such as mRS. Cognitive or social functions, level of symptom burden or emotional health are not usually assessed, nor are data available on long-term functional outcomes years after stroke.

Methods
Analysis of 1141 patients with AIS treated with IVT from two major German university hospitals between 2017 and 2020. Patient characteristics and short-term outcome were analysed from patient records. Long-term outcome of 228 patients with prior written informed consent was assessed via telephone survey using mRS and PROMs (EQ-5D-5L, EQ-VAS) 2.5 years after stroke.

Results
Predictors of excellent to good long-term outcome were younger age, event to door time ≤ 2 h, NIHSS ≤ 6 on admission and NIHSS ≤ 6 after IVT. Stroke recurrence was a negative predictor. Predictors of excellent quality of life at 2.5 years included age < 73 years, lower NIHSS after IVT, absence of hypertension. Quality of life was rated in all dimensions with a medium score of 1 and a medium EQ-VAS of 70, representing the good general health status of this stroke population.

Conclusion
Main predictors of an excellent to good long-term outcome and excellent QoL 2.5 years after stroke are younger age, lower NIHSS, and event to door time ≤ 2 h. Research on long-term outcome after disease and treatment is of utmost importance, as it has the ability to reveal the patient true functional outcome and quality of life and to provide information on the status of independence and self-esteem.
Impact of Medication Reconciliation in Oncology Early Phase Studies: A Drug-Drug Interaction Retrospective Study
Authors: Malifarge Laura , Deppenweiler Marine , Italiano Antoine , Lortal Barbara 
Published: November 2023

PURPOSE This study aims to investigate the impact of medication reconciliation (MR) conducted by pharmacists before patient enrollment and the initiation of investigational treatments. By implementing MR, the primary objective is to evaluate the extent to which the inclusion of patients with prohibited or not recommended concomitant medications in clinical trials can be significantly reduced. MATERIALS AND METHODS The study included all patients who participated in clinical trials and underwent MR between September 1, 2015, and September 1, 2020. To identify prohibited or monitored drugs, protocols and investigator’s brochures provided by the sponsor were meticulously reviewed and taken into consideration. RESULTS MR was performed for 501 patients, uncovering 35% of the medications they were currently taking. Through the pharmaceutical analysis, a total of 346 drug-drug interactions (DDIs) were identified, of which 188 required monitoring and 158 were strictly prohibited. More than half of the prohibited medications were herbal drugs. A significant portion of these prohibited drugs were discontinued, with only 6% being replaced by suitable alternatives. The implementation of MR played a crucial role in the identification of 51% of the prohibited or monitored drugs that were initially overlooked by oncologists. CONCLUSION MR is a highly effective measure aimed at reducing the risk of DDIs with investigational drugs, thereby minimizing protocol deviations and enhancing patient care. Sponsors of clinical trials value its implementation and recognize the substantial benefits it brings to the entire trial process. Consequently, many sponsors willingly provide funding to investigational sites that adopt MR as part of their standard practice, acknowledging its critical role in ensuring patient safety and maintaining data integrity throughout the course of clinical research studies.
A Case of Severe Lactation Ketoacidosis in a Nondiabetic Mother on a Ketogenic Diet
Authors: Borhan Marisa Khatijah , Vethakkan Shireene Ratna , Sarvanandan Tharsini , Paramasivam Sharmila Sunita 
Published: November 2023

Abstract
Lactation ketoacidosis is a rare yet severe metabolic emergency that has been reported in breastfeeding mothers. Reduced carbohydrate intake during breastfeeding has been reported as a common trigger for ketoacidosis. We report the case of a 31-year-old mother without diabetes who presented with life-threatening lactation ketoacidosis after following a ketogenic diet while exclusively breastfeeding her newborn baby. She was managed in the intensive care unit with dextrose and insulin infusion to reverse ketoacidosis. With prompt treatment, the patient's ketoacidosis resolved within 24 hours, and she was discharged well 3 days later. We further discuss the underlying increased metabolic demand in lactating women that puts them at risk of ketoacidosis, underlining the importance of early recognition of lactation ketoacidosis and nutritional education for lactating women.
Tiny spies: mosquito antennae are sensitive sensors for eavesdropping on frog calls
Authors: Pantoja-Sánchez Hoover , Leavell Brian C. , Rendon Bianca , de-Silva W. A. Priyanka P. , Singh Richa , Zhou Jian , Menda Gil , Hoy Ronald R. , Miles Ronald N. , Sanscrainte Neil D. , Bernal Ximena E. 
Published: November 2023

ABSTRACT
Most mosquito and midge species use hearing during acoustic mating behaviors. For frog-biting species, however, hearing plays an important role beyond mating as females rely on anuran calls to obtain blood meals. Despite the extensive work examining hearing in mosquito species that use sound in mating contexts, our understanding of how mosquitoes hear frog calls is limited. Here, we directly investigated the mechanisms underlying detection of frog calls by a mosquito species specialized on eavesdropping on anuran mating signals: Uranotaenia lowii. Behavioral, biomechanical and neurophysiological analyses revealed that the antenna of this frog-biting species can detect frog calls by relying on neural and mechanical responses comparable to those of non-frog-biting species. Our findings show that in Ur. lowii, contrary to most species, males do not use sound for mating, but females use hearing to locate their anuran host. We also show that the response of the antennae of this frog-biting species resembles that of the antenna of species that use hearing for mating. Finally, we discuss our data considering how mosquitoes may have evolved the ability to tap into the communication system of frogs.
Sideways maneuvers enable narrow aperture negotiation by free-flying hummingbirds
Authors: Badger Marc A. , McClain Kathryn , Smiley Ashley , Ye Jessica , Dudley Robert 
Published: November 2023

ABSTRACT
Many birds routinely fly fast through dense vegetation characterized by variably sized structures and voids. Successfully negotiating these cluttered environments requires maneuvering through narrow constrictions between obstacles. We show that Anna's hummingbirds (Calypte anna) can negotiate apertures less than one wingspan in diameter using a novel sideways maneuver that incorporates continuous, bilaterally asymmetric wing motions. Crucially, this maneuver allows hummingbirds to continue flapping as they negotiate the constriction. Even smaller openings are negotiated via a faster ballistic trajectory characterized by tucked and thus non-flapping wings, which reduces force production and increases descent rate relative to the asymmetric technique. Hummingbirds progressively shift to the swept method as they perform hundreds of consecutive transits, suggesting increased locomotor performance with task familiarity. Initial use of the slower asymmetric transit technique may allow birds to better assess upcoming obstacles and voids, thereby reducing the likelihood of subsequent collisions. Repeated disruptions of normal wing kinematics as birds negotiate tight apertures may determine the limits of flight performance in structurally complex environments. These strategies for aperture transit and associated flight trajectories can inform designs and algorithms for small aerial vehicles flying within cluttered environments.
Differential reaction norms to ocean acidification in two oyster species from contrasting habitats
Authors: Caillon Coline , Pernet Fabrice , Lutier Mathieu , Di Poi Carole 
Published: November 2023

ABSTRACT
Ocean acidification (OA), a consequence of the increase in anthropogenic emissions of carbon dioxide, causes major changes in the chemistry of carbonates in the ocean with deleterious effects on calcifying organisms. The pH/PCO2 range to which species are exposed in nature is important to consider when interpreting the response of coastal organisms to OA. In this context, emerging approaches, which assess the reaction norms of organisms to a wide pH gradient, are improving our understanding of tolerance thresholds and acclimation potential to OA. In this study, we deciphered the reaction norms of two oyster species living in contrasting habitats: the intertidal oyster Crassostrea gigas and the subtidal flat oyster Ostrea edulis, which are two economically and ecologically valuable species in temperate ecosystems. Six-month-old oysters of each species were exposed in common garden tanks for 48 days to a pH gradient ranging from 7.7 to 6.4 (total scale). Both species were tolerant down to a pH of 6.6 with high plasticity in fitness-related traits such as survival and growth. However, oysters underwent remodelling of membrane fatty acids to cope with decreasing pH along with shell bleaching impairing shell integrity and consequently animal fitness. Finally, our work revealed species-specific physiological responses and highlights that intertidal C. gigas seem to have a better acclimation potential to rapid and extreme OA changes than O. edulis. Overall, our study provides important data about the phenotypic plasticity and its limits in two oyster species, which is essential for assessing the challenges posed to marine organisms by OA.
Interference Pattern to Hybrid Pattern to Diffraction Pattern in
Non-Parallel Two-Slit Experiment --- Interaction Between Photons
Authors: Peng Hui 
Published: November 2023

The interference and the diffraction are two basic phenomena in physical optics. We have shown the phenomenon that, in the experiment of two slits with the certain angle between two slits, the partial interference pattern is embedded in the two diffraction patterns, namely, there is the partial interference + diffraction hybrid patterns.
angle	2 slits	Patterns	angle	2 slits	Patterns
00	30

60
120

180

240

300

360

420

450

In this article, we show that the nature and the characteristics of the patterns depend not only on the distance from the diaphragm, but also on the angle between two slits. Namely, when the angle between two slits varies from 00 to 450, the pattern varies from the interference pattern to the hybrid patterns (i.e., the partial interference pattern embedded in diffraction patterns) to the diffraction patterns. Challenge is to interpret consistently the hybrid patterns.
Distributed phase-matching measurement for dynamic strain and temperature sensing based on stimulated Brillouin scattering enhanced four-wave mixing
Authors: Wang Yuan , Tovar Pedro , Yang Juntong , Chen Liang , Bao Xiaoyi 
Published: November 2023

A Brillouin dynamic grating (BDG) can be used for distributed birefringence measurement in optical fibers, offering high sensitivity and spatial resolution for sensing applications. However, it is quite a challenge to simultaneously achieve dynamic measurements with both high accuracy and high spatial resolution. In this work, we propose a sensing mechanism to achieve distributed phase-matching measurement using a chirped pulse as a probe signal. In BDG reflection, the peak reflection corresponds to the highest four-wave mixing (FWM) conversion efficiency, and it requires the Brillouin frequency in the fast and slow axes to be equal, which is called the phase-matching condition. This condition changes at different fiber positions, which requires a range of frequency injection for the probe wave. The proposed method uses a chirped pulse as a probe wave to cover this frequency range associated with distributed birefringence inhomogeneity. This allows us to detect distributed phase matching for birefringence changes that are introduced by temperature and strain variations. Thanks to the single shot and direct time delay measurement capability, the acquisition rate in our system is only limited by the fiber length. Notably, unlike conventional BDG spectrum recovery-based systems, the spatial resolution here is determined by both the frequency chirping rate of the probe pulse and the birefringence profile of the fiber. In the experiments, an acquisition rate of 1 kHz (up to fiber length limits) and a spatial resolution of 10 cm using a 20 ns probe pulse width are achieved. The minimum detectable temperature and strain variation are 5.6 mK and 0.37 με along a 2 km long polarization-maintaining fiber (PMF).
Are C-reactive protein concentrations affected by smoking status and physical activity levels? A longitudinal study
Authors: Christofaro Diego G. D. , Ritti-Dias Raphael M. , Tebar William R. , Werneck André O. , Bittencourt Márcio S. , Cucato Gabriel G. , Santos Raul D. 
Published: November 2023

Background and objective
To compare high-sensitivity C-reactive protein (hsCRP) levels according to smoking status and physical activity (PA) changes in adults.

Methods
The sample consisted of 6028 participants (4833 men) who underwent a voluntary routine health evaluation at the Preventive Medicine Center at the Hospital Israelita Albert Einstein, Sao Paulo, Brazil, from January 2007 to December 2013. Data were collected at baseline and follow-up (2.7±1.6 years). Plasma hsCRP (in mg/L) was analyzed in both moments. Smoking status was obtained through a self-reported questionnaire, being participants classified as non-smokers, once smokers (report smoking at baseline or follow-up), and persistently smokers (reported smoking at both baseline and follow-up). PA was assessed by questionnaire in both moments, being participants classified as persistently inactive, became inactive, became active, and persistently active. The Rank Analysis of Covariance was used to compare hsCRP follow-up values according to smoking and physical activity status.

Results
Persistently smokers showed significantly higher median values of hsCRP at follow-up (1.3 mg/L, IQR:0.6–2.8) than once smokers (1.1 mg/L, IQR: 0.6–2.4) and non-smokers (1.0 mg/L, IQR: 0.5–2.2), even considering covariates (p<0.001). Persistently actives had lower levels of hsCRP at follow-up when compared to persistently inactive in the three smoking status groups (non-smokers p<0.001, once smokers p = 0.001, and persistently smokers p = 0.037).

Conclusion
Persistently active participants had lower hsCRP values at follow-up than those persistently inactive in all the smoking status groups. Regular practice of PA is an important strategy for facing low-grade inflammation, even among smokers.
Optimization and validation of 18F-DCFPyL PET radiomics-based machine learning models in intermediate- to high-risk primary prostate cancer
Authors: Luining Wietske I. , Oprea-Lager Daniela E. , Vis André N. , van Moorselaar Reindert J. A. , Knol Remco J. J. , Wondergem Maurits , Boellaard Ronald , Cysouw Matthijs C. F. 
Published: November 2023

IntroductionRadiomics extracted from prostate-specific membrane antigen (PSMA)-PET modeled with machine learning (ML) may be used for prediction of disease risk. However, validation of previously proposed approaches is lacking. We aimed to optimize and validate ML models based on18F-DCFPyL-PET radiomics for the prediction of lymph-node involvement (LNI), extracapsular extension (ECE), and postoperative Gleason score (GS) in primary prostate cancer (PCa) patients.MethodsPatients with intermediate- to high-risk PCa who underwent18F-DCFPyL-PET/CT before radical prostatectomy with pelvic lymph-node dissection were evaluated. The training dataset included 72 patients, the internal validation dataset 24 patients, and the external validation dataset 27 patients. PSMA-avid intra-prostatic lesions were delineated semi-automatically on PET and 480 radiomics features were extracted. Conventional PET-metrics were derived for comparative analysis. Segmentation, preprocessing, and ML methods were optimized in repeated 5-fold cross-validation (CV) on the training dataset. The trained models were tested on the combined validation dataset. Combat harmonization was applied to external radiomics data. Model performance was assessed using the receiver-operating-characteristics curve (AUC).ResultsThe CV-AUCs in the training dataset were 0.88, 0.79 and 0.84 for LNI, ECE, and GS, respectively. In the combined validation dataset, the ML models could significantly predict GS with an AUC of 0.78 (p<0.05). However, validation AUCs for LNI and ECE prediction were not significant (0.57 and 0.63, respectively). Conventional PET metrics-based models had comparable AUCs for LNI (0.59,p>0.05) and ECE (0.66,p>0.05), but a lower AUC for GS (0.73,p<0.05). In general, Combat harmonization improved external validation AUCs (-0.03 to +0.18).ConclusionIn internal and external validation,18F-DCFPyL-PET radiomics-based ML models predicted high postoperative GS but not LNI or ECE in intermediate- to high-risk PCa. Therefore, the clinical benefit seems to be limited. These results underline the need for external and/or multicenter validation of PET radiomics-based ML model analyses to assess their generalizability.
Social cognitive predictors of regular dental visits and mouth self-examination behaviors among the elderly population: An application of the health action process approach model
Authors: Moghaddam Fatemeh , Sargeran Katayoun , Gholami Mahdia , Jamali Jamshid , Shamshiri Ahmadreza 
Published: November 2023

Objective
The present study aimed to identify the social cognitive predictors of regular dental visits and mouth self-examination behaviors among the elderly population, based on the Health Action Process Approach (HAPA) model.

Background
Regular dental visits and mouth self-examination can prevent oral and dental problems among the elders. Little information is available regarding the social cognitive predictive factors of these two behaviors.

Materials and methods
A cross-sectional study was conducted in 24 municipality centers in Tehran, Iran in 2021. The centers were selected randomly using a multi-stage cluster sampling method and 301 elderly attendants aged 60≥years participated in the study. Data collection was done using a researcher-made questionnaire including demographic characteristics and the HAPA model constructs for two target behaviors. Data were analyzed using the Smart-PLS version 3.3.9 via correlation and PLS-SEM analysis.

Results
The mean age of the participants was 65.3±5.33 years and 79.7% were female. The SEM analysis showed that Action Self-Efficacy [b (SD) = 0.595 (0.065), P< 0.001] and Risk Perception [b (SD) = 0.218 (0.070), P< 0.002] were predictors of Intention for mouth self-examination but only Action Self-Efficacy [b (SD) = 0.651 (0.043), P< 0.001] was predictor of Intention for regular dental visits. Recovery Self-Efficacy and Planning directly contributed to the prediction of Mouth Self-Examination. The relationship between Maintenance Self-Efficacy and both behaviors is mediated by Planning. Also, the mediating role of Planning between Intention and target behaviors was confirmed.

Conclusion
Action self-efficacy predicted the intention for regular dental visits and mouth self-examination behaviors. The relationship between intention and both behaviors was mediated by Planning. Emphasis on improving Action Self-Efficacy and Intention formation will enhance the effectiveness of interventions aiming at promoting the oral health of the elderly population.
Investigating the relationship between erythropoiesis-stimulating agents and mortality in hemodialysis patients: A systematic review and meta-analysis
Authors: Karimi Zahra , Raeisi Shahraki Hadi , Mohammadian-Hafshejani Abdollah 
Published: November 2023

Background
In recent years, various studies have been conducted to investigate the relationship between erythropoiesis-stimulating agents (ESAs) and mortality in hemodialysis patients, who showed contradictory results. Therefore, this study aimed to investigate the relationship between ESAs and mortality in hemodialysis patients.

Methods
The current study is a systematic review and meta-analysis based on observational and interventional studies published in the Web of Science, Cochrane Library, Science Direct, PubMed, Scopus, and Google Scholar databases between 1980 and the end of 2022. Jadad scale checklist and Newcastle Ottawa scale were used to evaluate the quality of articles. The study data were analyzed using Stata 15 software.

Results
In the initial search, 3933 articles were extracted, and by screening and considering the research criteria, 68 studies were finally included in the meta-analysis. According to the meta-analysis results, the risk ratio (RR) of overall mortality in hemodialysis patients receiving ESAs was equal to 1.19 (95% CI: 1.16–1.23, P ≤ 0.001). The RR of mortality in patients aged 60 years and under was equal to 1.33 (1.15–1.55, P ≤ 0.001), in the age group over 60 years was equal to 1.13 (1.10–1.16, P ≤ 0.001), in randomized clinical trial studies was equal to 1.06 (0.80–1.40, P = 0.701), in cohort studies was equal to 1.20 (1.16–1.25, P ≤ 0.001), in American countries was equal to 1.19 (1.10–1.29, P ≤ 0.001), in Asian countries was equal to 1.15 (1.10–1.19, P ≤ 0.001), and in European countries was equal to 1.18 (1.05–1.34, P = 0.007).

Conclusion
The results of the study show that receiving ESAs is associated with a 19% increase in the risk of overall mortality in hemodialysis patients.
An Unusual Case of Black Esophagus
Authors: Ziegler Patricia E. , Rosario Lora Dauris , DeMeo Mark 
Published: November 2023

ABSTRACT
Patients with acute esophageal necrosis often present with hematemesis and upper gastrointestinal bleeding. Our case report describes a patient's incidental discovery of black esophagus without recent hemodynamic instability, symptoms, or evidence of blood loss anemia. As illustrated in this case, it is important to recognize these findings in patients without classic signs and symptoms to act promptly and prevent tissue ischemia or perforation. Early recognition can also help reduce the risk of long-term complications such as stricture formation. Thus, a high index of suspicion is essential for the diagnosis of acute esophageal necrosis.
C.C.E., 12 octobre 2022, n° 278 653 et 278 654, et 13 octobre 2022, n° 278 699, 278 700 et 278 701
Authors: Fontignie Isabelle 
Published: November 2023

Le Conseil du contentieux des étrangers aborde en chambre à trois juges plusieurs questions spécifiques dans le cadre de demandes de protection internationale de ressortissants afghans, restées « en attente » depuis le dernier arrêt rendu à trois juges le 31 mars 2022. Le tribunal se positionne notamment sur la question de l’« occidentalisation », et revient aussi sur les situations socio-économique, humanitaire et sécuritaire en Afghanistan. Dans un arrêt en particulier, le tribunal se penche sur le profil particulier des Hazaras.