bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISA PERESEPAN DAN INTERAKSI KOMBINASI DUA MACAM ANTIBIOTIK INTRAVENA DI RUMAH SAKIT X TANGERANG SELATAN
Authors: Chusun Chusun , Retno Fitriani , Yosep Fauzi 
Published: November 2023

One of the mainstay drugs to treat infections is antimicrobials, including antibacterials/antibiotics, antifungals, antivirals and antiprotozoa. Antibiotics are drugs used in infections caused by bacteria. Antibiotics that are not used wisely can lead to resistance problems. Therefore, the use of antibiotics must follow a rational strategy of prescribing antibiotics. Irrational prescribing will increase the occurrence of drug side effects, drug interactions, medical costs and result in decreased patient compliance in taking drugs.
The purpose of this study was to determine the pattern of prescribing combinations of intravenous antibiotics in one prescription sheet and their interactions.
This research is a type of quantitative research, with descriptive methods and using retrospective data. The population in this study were all prescription sheets of inpatients who had been served at the X Hospital Pharmacy Installation for the period January 1 to March 31, 2021. The samples were all prescription sheets containing a combination of 2 (two) intravenous antibiotics (injection or infusion), all of which totaling 170 sheets.
The results showed that there were more male patients than female patients, namely 52.3% with the largest age range between 46-55 years (29.41%). Of the 15 combinations of 2 (two) intravenous antibiotics, there were 6 combinations that had moderate pharmacodynamic interactions. Moderate interactions are clinically significant, usually avoided in combination or used only in special circumstances and with close monitoring of health workers. Of the 170 prescription sheets, 135 sheets (79.4%) were prescribed by internal medicine specialists. All intravenous antibiotics prescribed according to the X Hospital Formulary and the National Formulary.
PEMANFAATAN LIMBAH KULIT BAWANG PUTIH (Allium sativum L.) SEBAGAI BAHAN AKTIF PEMBUATAN SABUN CAIR
Authors: S Panji Ratih , R Sih Wahyu , Fitriyany Erna , I Cikra , Calya Finna , Sari Septiana 
Published: November 2023

Utilization of household waste in Indonesia is still very rarely done, one of which is the use of garlic skin waste. From research by Allemann & Baumann in 2008, garlic skin is rich in antioxidant compounds so it can protect skin cells from free radical damage if used as a skincare product, one of which is liquid bath soap for the body. This research aims to formulate garlic skin extract as liquid soap. The concentration used is 10%. The liquid soap formulation used was 17 g of SLS, 3 g of NaCl, 9 g of Cocamidopropyl Betaine, 9 g of Glycerin, Fragrances, and Dyes to taste. Garlic skin extract liquid soap is evaluated for its physical quality consisting of organoleptic test results in the form of liquid, gum-scented and red-colored, pH test of 8.2, height test and foam stability of 79 mm, moisture content test of 51.12%, specific gravity test of 1.012 g/ml, and irritation test declared non-irritating. The results showed that garlic skin extract liquid soap with a concentration of 10 % had a physical quality that complied with their requirements. This research concludes that garlic skin extracts liquid soap meets the requirements of the physical quality test and safe for the skin because it does not cause irritation to the skin when used.
Kinetic and equilibrium study of graphene and copper oxides modified nanocomposites for metal ions adsorption from binary metal aqueous solution
Authors: Ali Alaa H. , Kareem Asmaa Bahjat , Al-Rawi Usama A. , Khalid Ushna , Zhang Shengfu , Zafar Fatima , Papraćanin Edisa , Hatshan Mohammad Rafe , Sher Farooq 
Published: November 2023

Presently, the main cause of pollution of natural water resources is heavy metal ions. The removal of metal ions such as nickel (Ni2+) and cadmium (Cd2+) has been given considerable attention due to their health and environmental risks. In this regard, for wastewater treatment containing heavy metal ions, graphene oxide (GO) nanocomposites with metal oxide nanoparticles (NPs) attained significant importance. In this study, graphene oxide stacked with copper oxide nanocomposites (GO/CuO-NCs) were synthesized and characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), and atomic force microscopy (AFM) analytical procedures. The prepared GO/CuO-NCs were applied for the removal of Ni2+ and Cd2+ ions from a binary metal ion system in batch and continuous experiments. The obtained results revealed that GO/CuO-NCs exhibited the highest removal efficiencies of Ni2+ (89.60% ± 2.12%) and Cd2+ (97.10% ± 1.91%) at the optimum values of pH: 8, dose: 0.25 g, contact time: 60 min, and at 50 ppm initial metal ion concentration in a batch study. However, 4 mL/min flow rate, 50 ppm initial concentration, and 2 cm bed height were proved to be the suitable conditions for metal ion adsorption in the column study. The kinetic adsorption data exhibited the best fitting with the pseudo-second-order model. The adsorption isotherm provided the best-fitting data in the Langmuir isotherm model. This study suggested that the GO/CuO nanocomposites have proved to be efficient adsorbents for Ni2+ and Cd2+ ions from a binary metal system.
Describing the scattering of keV protons through graphene
Authors: Bühler Jakob , Roncin Philippe , Brand Christian 
Published: November 2023

Implementing two-dimensional materials in technological solutions requires fast, economic, and non-destructive tools to ensure efficient characterization. In this context, scattering of keV protons through free-standing graphene was proposed as an analytical tool. Here, we critically evaluate the predicted effects using classical simulations including a description of the lattice’s thermal motion and the membrane corrugation via statistical averaging. Our study shows that the zero-point motion of the lattice atoms alone leads to considerable broadening of the signal that is not properly described by thermal averaging of the interaction potential. In combination with the non-negligible probability for introducing defects, it limits the prospect of proton scattering at 5 keV as an analytic tool.
Increased fecal ethanol and enriched ethanol-producing gut bacteria Limosilactobacillus fermentum, Enterocloster bolteae, Mediterraneibacter gnavus and Streptococcus mutans in nonalcoholic steatohepatitis
Authors: Mbaye Babacar , Magdy Wasfy Reham , Borentain Patrick , Tidjani Alou Maryam , Mottola Giovanna , Bossi Vincent , Caputo Aurelia , Gerolami Rene , Million Matthieu 
Published: November 2023

BackgroundNon-alcoholic steatohepatitis (NASH) has become a major public health issue as one of the leading causes of liver disease and transplantation worldwide. The instrumental role of the gut microbiota is emerging but still under investigation. Endogenous ethanol (EtOH) production by gut bacteria and yeasts is an emerging putative mechanism. Microbial metagenomics and culture studies targeting enterobacteria or yeasts have been reported, but no culturomics studies have been conducted so far.AimTo assess fecal EtOH and other biochemical parameters, characterize NASH-associated dysbiosis and identify EtOH-producing gut microbes associated with the disease, fecal samples from 41 NASH patients and 24 controls were analyzed. High-performance liquid chromatography (HPLC) was used for EtOH, glucose, total proteins, triglyceride and total cholesterol. Viable bacteria were assessed with microbial culturomics. Microbial genetic material was assessed using 16S metagenomics targeting the hypervariable V3V4 region.ResultsFecal EtOH and glucose was elevated in the stools of NASH patients (p &lt; 0.05) but not triglyceride, total cholesterol or proteins. In culturomics, EtOH-producing Enterocloster bolteae and Limosilactobacillus fermentum were enriched in NASH. V3V4 16S rRNA amplicon sequencing confirmed the enrichment in EtOH-producing bacteria including L. fermentum, Mediterraneibacter gnavus and Streptococcus mutans, species previously associated with NASH and other dysbiosis-associated diseases. Strikingly, E. bolteae was identified only by culturomics. The well-known Lacticaseibacillus casei was identified in controls but never isolated in patients with NASH (p &lt; 0.05).ConclusionElevated fecal EtOH and glucose is a feature of NASH. Several different EtOH-producing gut bacteria may play an instrumental role in the disease. Culturomics and metagenomics, two complementary methods, will be critical to identify EtOH-producing bacteria for future diagnostic markers and therapeutic targets for NASH. Suppression of EtOH-producing gut microbes and L. casei administration are options to be tested in NASH treatment.
Identification CCL2,CXCR2,S100A9 of the immune-related gene markers and immune infiltration characteristics of inflammatory bowel disease and heart failure via bioinformatics analysis and machine learning
Authors: Luo Xu , Wang Rui , Zhang Xin , Wen Xin , Deng Siwei , Xie Wen 
Published: November 2023

BackgroundRecently, heart failure (HF) and inflammatory bowel disease (IBD) have been considered to be related diseases with increasing incidence rates; both diseases are related to immunity. This study aims to analyze and identify immune-related gene (IRG) markers of HF and IBD through bioinformatics and machine learning (ML) methods and to explore their immune infiltration characteristics.MethodsThis study used gene expressiondata (GSE120895, GSE21610, GSE4183) from the Gene Expression Omnibus (GEO) database to screen differentially expressed genes (DEGs) and compare them with IRGs from the ImmPort database to obtain differentially expressed immune-related genes (DIRGs). Functional enrichment analysis of IRGs was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, three machine models and protein–protein interactions (PPIs) were established to identify diagnostic biomarkers. The receiver operating characteristic (ROC) curves were applied to evaluate the diagnostic value of the candidate biomarkersin the validation set (GSE1145, GSE36807) and obtain their correlations with immune cells through the Spearman algorithm. Finally, the CIBERSORT algorithm was used to evaluate the immune cell infiltration of the two diseases.ResultsThirty-four DIRGs were screened and GO and KEGG analysis results showed that these genes are mainly related to inflammatory and immune responses. CCL2, CXCR2 and S100A9 were identified as biomarkers.The immune correlation results indicated in both diseases that CCL2 is positively correlated with mast cell activation, CXCR2 is positively correlated with neutrophils and S100A9 is positively correlated with neutrophils and mast cell activation. Analysis of immune characteristics showed that macrophages M2, macrophages M0 and neutrophils were present in both diseases.ConclusionsCCL2, CXCR2 and S100A9 are promising biomarkers that will become potential immunogenetic biomarkers for diagnosing comorbidities of HF and IBD. macrophages M2, macrophages M0, neutrophil-mediated inflammation and immune regulation play important roles in the development of HF and IBD and may become diagnostic and therapeutic targets.
Case Report: Successful endovascular treatment of acute type A aortic dissection
Authors: Pitts Leonard , Heck Roland , Montagner Matteo , Penkalla Adam , Kofler Markus , Falk Volkmar , Kempfert Jörg , Buz Semih 
Published: November 2023

IntroductionOpen surgical repair remains the current gold standard for the treatment of acute type A aortic dissection. However, especially elderly patients with relevant comorbidities who are deemed unfit for open surgery may benefit from a minimally invasive endovascular approach.MethodsWe report a case of an 80-year-old male with retrograde acute type A aortic dissection and peripheral malperfusion after receiving thoracic endovascular aortic repair due to thoracic aortic aneurysm. Our individualized endovascular approach consisted of left carotid-subclavian bypass, proximal extension of thoracic endovascular aortic repair using a covered stent graft and a single covered stent graft for the ascending aorta in combination with an uncovered stent for the aortic arch.ResultsPostoperative computed tomographic angiography demonstrated excellent outcome with no signs of endoleak or patent false lumen. Follow-up after 3.5 years showed a stable result with no signs of stent failure or dissection progress. No aortic re-interventions were needed in the further course.DiscussionAn individualized endovascular approach may be justified for acute type A aortic dissection in elderly patients with high surgical risk if performed in specialized aortic centers. Additional short-length stent graft devices are needed to address the anatomical challenges of the ascending aorta. For enhanced remodeling of the dissected aorta, the use of an additional uncovered stent may be advisable.
Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES
Authors: Cheng Guangdong , Wang Mengmeng , Sun Hao , Lai Jingjiang , Feng Yukun , Liu Hongjin , Shang Yuwang , Zhao Yuan , Zuo Bingli , Lu Youhua 
Published: November 2023

BackgroundThe fluctuation or even loss of estrogen level caused by menopause in women, and most gynecological cancers often occur before and after menopause, so the age of menopause may be related to the occurrence of gynecological cancer.AimTo investigate whether the age at menopause is independently associated with the incidence of gynecological cancers and to analyze the possible influencing factors.MethodsWe selected the NHANES public database to conduct the study, and by excluding relevant influencing factors, we finally included 5706 NHANES participants who had full data on age at menopause and the occurrence of gynecologic cancers to analyze the relationship between the amount of age at menopause and gynecologic cancers based on univariate or multifactorial logistic regression analysis. Further, the relationship between age at menopause and the prevalence of different gynecologic cancers was investigated, and changes in the prevalence of different gynecologic cancers by age at menopause subgroups were observed. Finally, other relevant factors affecting the prevalence of gynecologic cancers were further investigated by subgroup analysis as well as subcluster analysis.ResultsUnivariate logistic regression analysis between age at menopause and gynecologic tumor prevalence revealed a negative association between age at menopause and the prevalence of common gynecologic cancers ovarian and cervical cancer, and after adjusting for the effects of covariates, a higher risk of gynecologic tumors was found with statistically significant differences at earlier age at menopause. The regression results showed a negative association between age at menopause and gynecologic cancer prevalence in cervical and ovarian cancer patients (P&lt;0.01,P&lt;0.01). Cervical cancer (OR: 0.91, 95% CI: 0.87,0.94) and ovarian cancer (OR: 0.90, 95% CI: 0.86, 0.95) were more prevalent among those with younger age at menopause.ConclusionAge at menopause is negatively associated with the prevalence of cervical and ovarian cancers, and the earlier the age at menopause, the greater the risk of developing gynecological cancers.
Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study
Authors: Bai Chenxue , Shen Zixiong , Qiu Binxu , Zhang Songling 
Published: November 2023

BackgroundEndometriosis (EMs) is a common gynecological disorder. Observational studies on the relationship between leukocyte telomere length (LTL) and EMs have shown conflicting results. The purpose of this study was to evaluate the precise causal relationship between LTL and EMs using Mendelian randomization (MR) methodology.MethodsWe employed MR to assess the causal relationship between LTL and EMs. Summary data from several large-scale genome-wide association studies (GWAS) were used for bidirectional two-sample MR analysis. Sensitivity analyses were conducted to ensure the robustness of our results. All analyses were also replicated in another completely independent EMs dataset.ResultsOur MR analysis indicated that genetically predicted longer LTL increased the risk of EMs (IVW: discovery, OR=1.169, 95%CI: 1.059-1.290, p=0.002; validation, OR=1.302, 95%CI: 1.140-1.487, p=0.000), while EMs had no causal impact on LTL (IVW: discovery, OR=1.013, 95%CI: 1.000-1.027, p=0.056; IVW: validation, OR=1.005, 95%CI: 0.995-1.015, p=0.363). Causal estimates were supported by various calculation models (including MR-Egger, Weighted median, MR-PRESSO, and MR-RAPS). Heterogeneity and pleiotropy analyses also indicated robustness of the results.ConclusionOur findings substantiate the idea that a genetically predicted longer LTL elevates the risk of EMs, with no influence of EMs on LTL risk. This research bolsters the causal link between LTL and EMs, overcoming the constraints of earlier observational studies. It implies that LTL may potentially function as a biomarker for EMs, opening up novel possibilities for EMs prevention and treatment.
Review of multiple load forecasting method for integrated energy system
Authors: Liu Yujiao , Li Yan , Li Guoliang , Lin Yuqing , Wang Ruiqi , Fan Yunpeng 
Published: November 2023

In order to further improve the efficiency of energy utilization, Integrated Energy Systems (IES) connect various energy systems closer, which has become an important energy utilization mode in the process of energy transition. Because the complex and variable multiple load is an important part of the new power system, the load forecasting is of great significance for the planning, operation, control, and dispatching of the new power system. In order to timely track the latest research progress of the load forecasting method and grasp the current research hotspot and the direction of load forecasting, this paper reviews the relevant research content of the forecasting methods. Firstly, a brief overview of Integrated Energy Systems and load forecasting is provided. Secondly, traditional forecasting methods based on statistical analysis and intelligent forecasting methods based on machine learning are discussed in two directions to analyze the advantages, disadvantages, and applicability of different methods. Then, the results of Integrated Energy Systemss multiple load forecasting for the past 5 years are compiled and analyzed. Finally, the Integrated Energy Systems load forecasting is summarized and looked forward.
Predicted changes in habitat suitability for human schistosomiasis intermediate host snails for modelled future climatic conditions in KwaZulu-Natal, South Africa
Authors: Nwoko Onyekachi Esther , Manyangadze Tawanda , Chimbari Moses John 
Published: November 2023

Introduction: Climate change alters environmental and climatic conditions, leading to expansion or contraction and possible shifts in the geographical distribution of vectors that transmit diseases. Bulinus globosus and Biomphalaria pfeifferi are the intermediate host snails for human schistosomiasis in KwaZulu-Natal (KZN) province, South Africa.Methods: Using the Maximum entropy (MaxEnt) model, we modelled the current and future distribution of human schistosomiasis intermediate host snails in KZN using two representation concentration pathways (RCP4.5 and RCP8.5) for the year 2085. Thirteen and ten bioclimatic variables from AFRICLIM were used to model the habitat suitability for B. globosus and B. pfeifferi, respectively. The Jack-knife test was used to evaluate the importance of each bioclimatic variable.Results: Mean temperature warmest quarter (BIO10, 37.6%), the number of dry months (dm, 32.6%), mean diurnal range in temperature (BIO2, 10.8%), isothermality (BIO3, 6.7%) were identified as the top four bioclimatic variables with significant contribution to the model for predicting the habitat suitability for B. globosus. Annual moisture index (mi, 34%), mean temperature warmest quarter (BIO10, 21.5%), isothermality (BIO3, 20.5%), and number of dry months (dm, 7%) were identified as the four important variables for the habitat suitability of B. pfeifferi. Area under the curve for the receiving operating characteristics was used to evaluate the performance of the model. The MaxEnt model obtained high AUC values of 0.791 and 0.896 for B. globosus and B. pfeifferi, respectively. Possible changes in the habitat suitability for B. globosus and B. pfeifferi were observed in the maps developed, indicating shrinkage and shifts in the habitat suitability of B. pfeifferi as 65.1% and 59.7% of the current suitable habitats may become unsuitable in the future under RCP4.5 and RCP8.5 climate scenarios. Conversely, an expansion in suitable habitats for B. globosus was predicted to be 32.4% and 69.3% under RCP4.5 and RCP8.5 climate scenarios, with some currently unsuitable habitats becoming suitable in the future.Discussion: These habitat suitability predictions for human schistosomiasis intermediate host snails in KZN can be used as a reference for implementing long-term effective preventive and control strategies for schistosomiasis.
Development of clinical trials for non-small cell lung cancer drugs in China from 2005 to 2023
Authors: Jia Wanying , Yu Haiyan , Song Li , Wang Jian , Niu Shuyu , Zang Guojie , Liang Mingjie , Liu Jinwei , Na Risu 
Published: November 2023

ObjectiveOver the past few decades, the development of anti-cancer drugs in China has made outstanding achievements based on the support of national policies. To assess the progress of non-small cell lung cancer (NSCLC) drugs, we conducted a statistical analysis of clinical trials of drugs targeting NSCLC in China from 2005 to 2023.MethodsWe downloaded, screened and analysed the data from three official websites, the Centre for Drug Evaluation of China National Medical Products Administration website (NMPA), ClinicalTrials.gov and the Chinese Clinical Trial Registry (ChiCTR).ResultsFrom January 1, 2005 to April 15, 2023, a total of 1,357 drug clinical trials that met the standards were included, and the number of registered drug clinical trials has been increasing year by year, reaching the maximum of 199 in 2021. Among them, the maximum of 462 items (34.05%) in phase II clinical trials, followed by 333 (24.54%) in phase III clinical trials, and 139 (10.24%) in phase IV clinical trials. In all drug clinical trials, industry sponsored trials (ISTs) have 722 items (53.21%), which are higher than investigator-initiated trials (IITs). The clinical trials of chemical drugs have a maximum of 723 items (53.28%), while biopharmaceuticals have grown rapidly in the past 10 years, with a total of 374 (27.56%), and 48.19% of the drug clinical trials of combined medication. In addition, the geographical distribution of the leading units and participating units of Chinese drug clinical trials are uneven, and economic regions such as Beijing, Shanghai, Jiangsu are obviously ahead of other regions.ConclusionFrom 2005 to 2023, the clinical trials of registered drugs for the treatment of NSCLC increased rapidly. Among them, due to the development of immunotherapy, the clinical trials of biopharmaceuticals and drugs for combined medication are growing most rapidly, while the exploration of the original drugs is a little far from enough. Our research provides a direction for the future drug clinical trials of NSCLC, laying foundation for further extending the survival rate of patients with NSCLC.