bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operating under the influence: The effect of alcohol on operative performance using a virtual robotic training platform - an experimental comparative cohort study
Authors: Muensterer Oliver J. , Apelt Nadja , Schnorpfeil Corinna , Kaufmann Thomas , Goedeke Jan 
Published: January 2024

Abstract
Background: An elevated percentage of medical personnel reports using alcohol to relieve stress. Levels of alcohol addiction are almost double that of the general population. Robotic surgery is becoming more widespread. The purpose of this study is to evaluate the effects of alcohol ingestion on performance of a standardized curriculum using a robotic training platform.
Materials and Methods: Surgeons and surgical trainees were recruited. Candidates performed 4 standardized exercises (Vitruvian Operation (VO), Stacking Challenge (SC), Ring Tower (RT), Suture Sponge (SS)) at 0.0 blood alcohol concentration (BAC), followed by testing in the elimination phase at a target BAC of 0.8‰. Learning effects were minimised through prior training.
Results: A total of 20 participants were recruited. Scores for RT and SS exercises were significantly worse under the influence of alcohol [instruments out of view (SS (z=2.012; p=0.044), RT (z-score 1.940, p=0.049)), drops (SS (z=3.250; p=0.001)), instrument collisions (SS (z=2.460; p=0.014)), missed targets (SS (z=2.907; p=0.004)]. None of the scores improved with alcohol consumption, and there were measurable deleterious effects on the compound indicators risk affinity and tissue handling.
Conclusion: Despite the potential mitigating features of robotic surgery including tremor filtration, motion scaling, and improved three-dimensional visualization, alcohol consumption was associated with a significant increase in risk affinity and rough tissue handling, along with a deterioration of performance in select virtual robotic tasks. In the interest of patient safety, alcohol should not be consumed prior to performing robotic surgery and sufficiently long intervals between alcohol ingestion and surgical performance are mandatory.
Deep Learning Techniques for Predicting Student’s Academic Performance on Virtual Learning Environments: A Review
Authors: Alnasyan Bayan , Basheri Mohammed , Alassafi Madini 
Published: January 2024

Abstract

With advances in Artificial Intelligence (AI) and the increasing volume of online educational data, Deep Learning techniques have played a critical role in predicting student’s academic performance. Recent developments have assisted instructors in determining the strengths and weaknesses of student’s academic achievement. This understanding will benefit from adopting the necessary interventions to assist students in improving their performance, helping at-risk students, and preventing dropout rates. In this review, 46 studies between 2019 and 2023 that apply one or more Deep Learning (DL) techniques, either alone or in combination with Machine Learning (ML) or Ensemble Learning techniques, have been reviewed and analyzed. Moreover, the review has examined utilizing datasets from public (MOOCs), private (LMSs), and other platforms. Four categories were used to group the features: demographic, previous and current academic performance, and learning behavior/activity features. Therefore, the analysis has demonstrated that the DNNs and CNN-LSTM models were the most commonly used techniques. Moreover, it has been noted that the studies that have used DL techniques such as CNNs, DNNs, and LSTMs, performed well by achieving high prediction accuracy above 90%; other studies achieved accuracy ranging between 60% and 90%. For datasets used within the reviewed studies, even though 44% of the studies have used LMSs datasets, it is found that OULAD was the most used dataset from MOOCs. For the grouped features, the results of the analysis indicate that the best features for prediction are the learning behavior and activity features, which outperform other feature categories.
Islamic Financial Development, FDI and Economic Growth in MENA and East Asia and the Pacific: Theoretical Analysis and Empirical Study
Authors: MTIRAOUI Abderraouf Ahmed , HAMDAOUI Mekki , MHIRI Rania 
Published: January 2024

Abstract
The purpose of this paper is to study the interaction between Islamic financial development, FDI and economic growth. To do this, we are conducting regressions on simultaneous equation models for the region MENA and East Asia and the Pacific. First, we support a direct relationship between "Islamic financial development and economic growth". Next, our study highlights the indirect effects of Islamic financial development on economic growth through FDI. Finally, our results support significant effects of financial development in improving socio-economic conditions over the period 1990-2018.
JEL classification : C23, E44, O16.
Entrepreneurship between Quality of Governance and Economic Growth in the MENA Region
Authors: MTIRAOUI Abderraouf Ahmed , TALBI Najoua , SLIMENE Nadia , LASSOUED Mongi 
Published: January 2024

Abstract
The objective of this paper is to study the interactions between “the quality of governance”, “entrepreneurship”and “economic growth” according to the examination of the direct and indirect impacts of the quality of governance on economic growth through the indicator of total entrepreneurial activity. Early entrepreneurial “Total early stage entrepreneurial activity” noted (LNTEA) and entrepreneurial activities on growth through the governance quality indicator “governance quality indicator” noted (QGI). We introduce a conditional information matrix to control the variables that affect long-term economic growth, namely “rated economic growth (GDP) over the period 1996-2019 for the MENA region.
JEL classification : F29, C23, O16.
Concept and Evolution in 3D Printing for Excellence in Healthcare
Authors: Sinha Priyank , Lahare Preeti , Sahu Meena , Cimler Richard , Schnitzer Marek , Hlubenova Jana , Hudak Radovan , Singh Namrata , Gupta Bhanushree , Kuca Kamil 
Published: January 2024

Abstract:
Three-dimensional printing (3DP) has gained popularity among scientists and
researchers in every field due to its potential to drastically reduce energy costs for the
production of customized products by utilizing less energy-intensive machines as well
as minimizing material waste. The 3D printing technology is an additive manufacturing
approach that uses material layer-by-layer fabrication to produce the digitally specified
3D model. The use of 3D printing technology in the pharmaceutical sector has the potential
to revolutionize research and development by providing a quick and easy means to
manufacture personalized one-off batches, each with unique dosages, distinct substances,
shapes, and sizes, as well as variable release rates. This overview addresses the
concept of 3D printing, its evolution, and its operation, as well as the most popular types
of 3D printing processes utilized in the health care industry. It also discusses the application
of these cutting-edge technologies to the pharmaceutical industry, advancements in
various medical fields and medical equipment, 3D bioprinting, the most recent initiatives
to combat COVID-19, regulatory frameworks, and the major challenges that this
technology currently faces. In addition, we attempt to provide some futuristic approaches
to 3DP applications.
Association of CirAEs and Efficacy in NSCLC Patients Treated with PD-1/PD-L1: A Meta-analysis of Cohort Studies
Authors: Lu Junru , Zhu Jiaming , Jiang Guan 
Published: January 2024

Purpose:
To systematically evaluate the relationship between cutaneous immunerelated
adverse events (cirAEs) and the efficacy of PD-1/PD-L1 in the treatment of non-small
cell lung cancer (NSCLC) and to provide an evidence-based reference for the clinical application
of PD-1/PD-L1 and safety evaluation.

Methods:
Electronic databases (PubMed, Embase, Medline, Web of Science, and the Cochrane
Library) were screened systematically to collect prospective or retrospective cohort studies on
the correlation between cirAEs and efficacy of PD-1/PD-L1 in the treatment of NSCLC.

Results:
A total of 3514 participants were included in 13 cohort studies (enclosing an ambidirectional
cohort study). Outcomes revealed that compared with those patients with non cirAEs, patients
suffering cirAEs were associated with significantly higher objective response rate (ORR)
[risk ratio (RR): 1.74, 95% confidence interval (CI): 1.42–2.14, P<0.00001], longer progressionfree
survival (PFS) [RR: 0.52, 95% CI: 0.45–0.60, P<0.00001], and longer overall survival (OS)
[RR:0.46, 95% CI: 0.38–0.56]. Sensitivity analyses through the exclusion of one study at a time
did not significantly influence the outcomes, indicating that the meta-analysis results were relatively
robust. Furthermore, subgroup analyses revealed consistent results in the study design
(prospective or retrospective cohort studies), as well as in the endpoint results (PFS and OS) of
Kaplan–Meier curves or Cox proportional hazards regression for evaluable patients.

Conclusion:
Currently, evidence reveals that cirAEs development may be associated with a good
prognosis and can be an early predictor of the efficacy of PD-1/PD-L1 in the treatment of
NSCLC patients.
A Green and Convenient Approach for the Synthesis of
Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media
Authors: Zonouz Adeleh Moshtaghi , Moghani Davoud 
Published: January 2024

Abstract:
Indole–acrylonitrile hybrids were synthesized via a catalyst-free reaction of aromatic aldehydes
and 3-(cyanoacetyl)indole in aqueous media. Also, indole-coumarin hybrids were synthesized
via a domino reaction of salicylaldehyde derivatives and 3-(cyanoacetyl)indole in the presence
of ammonium acetate in aqueous media. The advantages of the present protocol are high yields,
short reaction times, mild reaction conditions, operational simplicity, and environmentally benign,
and also there is no need to purification of products.
Present Scenario and Future Prospects in the Management of Retinoblastoma: A Review
Authors: Shrivastava Vikas , Kumar Sharma Pramod , Pant Kamal , Banik Rahul 
Published: January 2024

:
Retinoblastoma is the most common pediatric ocular cancer. This cancer occurs due to
malignancy in retinoblast cells, which are precursors of photoreceptors, horizontal cells, amacrine
cells, muller cells, and retinal progenitor cells in the retina of the eye. Genetic correlation has been
observed in most cases of retinoblastoma. It is caused due to the suppression or mutation of the retinoblastoma
1 gene (RB1 gene), which is located at the 14th band of both alleles of the 13th human
chromosome. RB1 gene is a tumour suppressor gene responsible for regulating cell growth and controlling
abnormal cell division. In the last two decades, as accurate identification of characteristic features
of cancer cells at various stages of retinoblastoma has been made, we can now plan more advanced
and personalized management of the disease due to improved and focused therapeutic effects
of cryotherapy, thermotherapy, radiotherapy, chemotherapy, and surgical interventions. These efforts
can lead to a better survival rate with reduced damage to the non-cancerous cells in the eyeball, promoting
better visual performance (better visual acuity and visual axis alignment). Based on studies
published in PubMed and Google Scholar till 2023, current treatment options at various stages of retinoblastoma
are reviewed to suggest the most promising treatment options. Based on this information,
a clear treatment flowchart has been prepared. This review article can assist researchers, eye
specialists, geneticists, and cancer specialists in determining the most promising method for treating
retinoblastoma at various stages.
Current State of Deepfake Detection and Generation: A Review
Authors: Chauhan Ruby , Kansal Isha , Popli Renu , Kumar Rajeev , Sharma Ashutosh 
Published: January 2024

Abstract:
Employing machine learning algorithms to produce synthetic media, known as deepfake
technology, has garnered considerable interest in contemporary times owing to its capacity
for both favorable and unfavorable implications. The paper thoroughly examines deepfake technology,
encompassing its creation and identification methods and its legal, ethical, and societal
ramifications. The article commences by presenting a comprehensive summary of the technology
behind deepfake and its fundamental machine-learning algorithms. The subsequent discourse
pertains to the basic metrics employed in assessing deepfake generation, the identification methodologies,
and the prevalent benchmarks and datasets utilized for evaluating these algorithms.
The study thoroughly examines deepfake technology, encompassing its methods of generation
and detection, metrics for evaluation, datasets for benchmarking, and the challenges and constraints
associated with its use. The review scrutinizes diverse techniques for generating deep
fakes, encompassing Generative Adversarial Networks (GANs), autoencoders, and neural networks.
Style transfer, alongside their corresponding metrics for evaluation, namely Peak Signalto-
Noise Ratio (PSNR), Structural Similarity Index (SSIM), Fréchet Inception Distance (FID),
and Inception Score (IS). The text delves into an analysis of deepfake detection techniques, encompassing
image and video-based methodologies and the corresponding evaluation metrics.
These metrics include accuracy, recall, F1 score, accuracy, AUC-ROC, and AUC-PR. The article
additionally examines the benchmarks and datasets employed to evaluate the efficacy of deepfake
detection algorithms. These include the Deepfake Detection Challenge (DFDC), the FaceForensics++,
Celeb-DF, and DeeperForensics-1.0 datasets. This paper presents an overview of the
challenges and limitations of generating and detecting deepfakes.
PERANCANGAN SISTEM INFORMASI KULIAH KERJA PRAKTIK BERBASIS WEBSITE
Authors: AR Khairan , Ahmad Nazaruddin , Hadinegoro Arifiyanto , Ikramillah Syauqi 
Published: January 2024

Kuliah Kerja Praktk (KKP) adalah mata kuliah yang memberikan pemahaman kepada mahasiswa tentang dunia kerja. Mata kuliah ini bertujuan memberikan wawasan kepada mahasiswa bagaimana lingkungan kerja dan bagaimana mengimplementasikan keilmuan di bidang Teknologi Informasi di tempat praktik. Pendataan mahasiswa yang mengikuti kegiatan ini sangat penting, terkait dengan pendataan instansi tempat mahasiswa melakukan kegiatan kuliah kerja praktik. Dibangunlah sebuah sistem informasi kuliah kerja praktik berbasis website menggunakan bahasa pemrograman php, dengan database nya menggunakan MySQL, dan framework yang digunakan adalah codeigniter. Model pengembangan perangkat lunak yang digunakan adalah model Waterfall Untuk melihat kesesuaian fungsionalitas dari aplikasi dilakukan pengujian black box testing untuk melihat keberhasilan dari fungsionalitas aplikasi. Sistem informasi ini dibangun untuk memudahkan pendataan mahasiswa yang melaksanakan kegiatan kuliah kerja praktik, mengurangi kesalahan pendataan dan memberikan kemudahan penyimpanan data. Hasil pengujian yang dilakukan sistem informasi kuliah kerja praktik ini layak untuk digunakan sebagai alat bantu dalam pengelolaan data pelaksanaan kuliah kerja praktik.
PENATALAKSANAAN FISIOTERAPI PADA KASUS POST OPERASI MENISCUS REPAIR DEXTRA DI KLINIK BINTANG PHYSIO : STUDI KASUS
Authors: Lesmana Doan , Herawati Isnaini , Meidania Monalisa 
Published: January 2024

Pendahuluan: Robekan meniskus merupakan salah satu yang paling umum cedera lutut yang dirawat. Meniskus sangat penting untuk fungsi normal lutut, termasuk beban transmisi, stabilitas sendi, pelumasan, dan nutrisi dari tulang rawan artikular. Hilangnya fungsi meniskus normal menyebabkan peningkatan tekanan kontak lutut dan tulang rawan articular degenerasi dari waktu ke waktu. Perbaikan meniscus (meniscus repair) adalah salah satu jenis operasi yang dilakukan Ketika meniscus haru dilakukan operasi dengan cara menjahit meniscus yang mengalami robekan. Fisioterapi sangat berperan penting dalam perbaikan meniscus dengan latihan isometric, isokinetic yang bertujuan untuk menguatkan grub otot-otot yang lemah. Tujuan: meningkatkan ke fase seterusnya dan meningkatkan aktivitas fungsional untuk bisa Kembali kebidang olahraga. Metode: subjek diberikan latihan penguatan isometric dan isokinetic selama 4 minggu yang dilakukan 3x/minggu. Hasil: evaluasi dilakukan dengan menggunakan instrument penggukuran Visual Analog Scale (VAS), Range Of Motion (ROM), Manual Muscle Testing, dan Antropometri. Kesimpulan: terdapat peningkatan pada ROM, MMT, dan Antropometri setelah diberikan terapi Lathan selama 4 minggu.
ULUSLARARASI GÖÇÜN EĞİTİM VE OKUL YÖNETİMİNE YANSIMALARI
Authors: TAŞDAN Murat 
Published: January 2024

Göç, ekonomik, sosyal, siyasal, kültürel, teknolojik, çevresel veya bireysel faktörlere bağlı olarak insanların yer ve mekân değiştirmesi biçiminde tanımlanabilir. Göç, daha çok coğrafi değişiklik üzerinde nitelendirilse de siyaset, ekonomi ve kültür gibi kapsamlı beşerî alanlarla da ilişkili sosyal olgudur. Kitlesel göç akışlarının eğitim sistemleri üzerindeki etkisine yönelik az sayıda çalışma yapılmış olmasına rağmen, bu karmaşık gerçeklik araştırma alanına yeterince yansımamıştır. Bu çalışmada eğitim ve eğitim yönetimi alanında yeterince irdelenmeyen uluslararası göç konusu; uluslararası göçün ne olduğu, tarihsel süreçte nasıl yaşandığı, uluslararası göçün nedenleri, uluslararası göçün eğitime, eğitim politikalarına, eğitim ve okul yönetimine getirdiği ve getireceği zorluklar alanyazına dayalı olarak tartışılmıştır. Okul yöneticilerinin, göçmenler ile mülteciler için eşitlikçi ve adil bir eğitimin sağlanmasında önemli rolü bulunmaktadır. Okul yöneticileri, göçmen çocukların eğitiminde, öğrenciler ve diğer okul çalışanları için okul örgütünün lideridirler. Ayrıca, okul yöneticileri pedagojik alanın yönlendirilmesine ve geliştirilmesine katkıda bulunurlar. Mevcut eğitim liderliği modelleri göçmenlerin ve mültecilerin benzersiz ihtiyaçlarını ve deneyimlerini ele almak için yetersiz kalmaktadır. Göç sonrası aşamada, okul yöneticilerinin okulun işleyişini organize etmede önemli bir rolü bulunmaktadır. Eğitim programlarının hazırlanmasında sınıflarda yeni yaklaşımın desteklenmesinde, içeriğin var oluş şekli ve öğretim stili konularında göçmenlere duyarlı bir ortam oluşturulmalıdır. Eğitim sistemlerinde göçmen
toplulukların yerel, ulusal ya da uluslararası ihtiyaçlarını karşılamak için kaynaklar seferber edilmeli, çalışmalar ve çalışanlar arasında koordinasyon sağlanmalı ve eğitim politikaları yeniden yapılanmalıdır.
Endometrial concentrations of ampicillin in mares after intrauterine infusion of the drug
Authors: Love C. C. , Strzemienski P. J. , Kenney R. M. 
Published: January 2024

SUMMARY
Serum concentration of ampicillin, a semisynthetic penicillin, was measured in mares at various time intervals up to 24 hours after intrauterine infusion of 3 g of ampicillin. Blood samples were drawn immediately before infusion and at 1-, 4-, 10- and 24-hour intervals after infusion. At postinfusion hour 24, two endometrial biopsy specimens were obtained to measure endometrial concentrations of ampicillin. Blood was drawn twice as part of the 24-hour postinfusion sample collection, once before removal of the biopsy specimens and again 5 minutes after removal of the biopsy specimens.
After drug infusion, more diestrous mares had detectable serum ampicillin concentration than did estrous mares for all samples, except the 24-hour prebiopsy sample. None of the 24-hour prebiopsy serum samples had detectable ampicillin concentration, but ampicillin was detected in the serum of 4 of 5 diestrous mares after endometrial biopsy.
Endometrial concentrations of ampicillin were detectable at postinfusion hour 24 in estrous and diestrous mares, but were not different. All 24-hour biopsy specimens had ampicillin concentrations greater than the ampicillin minimal inhibitory concentration.
Humoral immune response to immediate-early protein of pseudorabies virus in swine with induced or naturally acquired infection
Authors: Cheung Andrew K. 
Published: January 2024

SUMMARY
Pseudorabies virus (prv) immediate-early (ie) protein is a nonglycosylated polypeptide localized in the nuclei of infected cells. The ie protein is a regulatory protein that is only synthesized during viral replication and is presented to the immune system of prv-infected swine. Antibodies to the ie protein were demonstrated in swine with induced or naturally acquired infection. However, antiserum raised against purified ie protein could not neutralize prv in vitro.
Anatomy of the orbital fasciae and the third eyelid in dogs
Authors: Constantinescu Gheorghe M. , McClure Robert C. 
Published: January 2024

SUMMARY
The connective tissue structures commonly referred to as the periorbita, orbital septum, muscular fasciae, and vagina bulbi or collectively, as the orbital fasciae were dissected then illustrated and described.
Two sheets (layers) of the periorbita (endorbita) were found in our dogs. The periorbita should be renamed endorbita because of its anatomic relations. The periorbita did not always fuse with the periosteum of frontal and sphenoid bones. Rather, the periorbita and the periosteum were often distinct and separate; only medioventrally did several fibrous bands unite the superficial sheet of the endorbita with the periosteum. Two layers of the endorbita fused with the periosteum of the margin of the bony orbit and with the orbital ligament.
The muscular fasciae were divided into 3 layers. The superficial layer extended caudally from the orbital septum, was thick, and was pierced by arteries, veins, and nerves. The middle layer was attached to the sclerocorneal junction and, at the temporal canthus of the eye, was divided into superficial and deep sheets. The deep portion was attached to the lateral angle of the third eyelid, similar to a strong ligament. The deep layer of the muscular fasciae extended caudally from the sclerocorneal junction in intimate contact with recti and oblique muscles of the eyeball. The deep portion of the deep muscular fascia covered the deep surface of all recti muscles and separated them from the retractor bulbi muscle. Intermuscular septa were observed between middle and deep muscular fascia layers. The body of the third eyelid was located between superficial and middle muscular fascia layers and was fixed ventrally to the lateral angle of the eye by the deep sheet of the middle muscular fascia.
Effect of growth in cell cultures and strain on virulence of Mycoplasma hyopneumoniae for swine
Authors: Zielinski Gustavo C. , Ross Richard F. 
Published: January 2024

SUMMARY
In an attempt to develop better methods for consistent induction of pneumonia in naturally born swine, using cultures of Mycoplasma hyopneumoniae, fifty 6-week-old, naturally born pigs from a respiratory disease-free herd were used in 3 trials. Pigs inoculated with Mycoplasma hyopneumoniae strain 232 (passage 21) grown for 1 passage or 5 passages in Eagle minimal essential medium plus 20% porcine serum, with or without human lung fibroblasts, had a mean (± sd) value range between 5.4 ± 3.6 and 9.2 ± 2.1% of consolidated lung area. In the second trial, pigs inoculated 1, 2, or 3 days in succession with strain 232 grown in Eagle medium or Friis mycoplasmal medium with 20% porcine serum had between 5.1 ± 7 and 8.7 ± 4.3% of consolidated lung area. In the third trial, virulence of Mycoplasma hyopneumoniae strains 144L (p27), 11 (p26), J (p60), and 232 (p27) grown in Friis mycoplasmal medium was compared. Pigs inoculated with those strains had 5.1 ± 4.1, 2.6 ± 3.1, 0, and 4.3 ± 4% of consolidated lung area, respectively. Significant differences were not found in consolidated lung area among groups in trials 1 and 2, and among groups of pigs inoculated with M hyopneumoniae strains 144L, 11, and 232 in trial 3. Pneumonia was not detected in pigs inoculated with strain J in trial 3.