bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniform formation and characterization of Au/TiO2 nanoparticles for electrokinetically assisted optofluidic reactors
Authors: Seo Eunseok , Jung Jaehyun , Wang Cong , Park Jungyul 
Published: December 2023

AbstractResearch is being conducted on photocatalyst-based organic compound treatment processes for water purification to decompose wastewater efficiently. An optofluidic reactor based on TiO2 photocatalysis and nanoelectrokinetics was presented recently to improve the efficacy of photocatalytic water purification. However, inefficient absorption of visible light by TiO2 materials hinders the effective utilization of solar energy. To address this issue, the uniform formation and characterization of Au/TiO2 nanoparticles for a plasmonic photocatalytic-based optofluidic platform are studied to improve photocatalytic reactivity in visible light. The present study uses UV irradiation and spray spraying for producing Au/TiO2 NPs uniformly on microporous carbon fabric. Energy dispersive X-ray analysis (EDX), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray diffraction (XRD) were used to assess the quality of the Au/TiO2 NP-coated carbon fabric. Au NPs were uniformly obtained on the surface and inside the TiO2 coating layer by UV irradiation-based photo-reduction, according to SEM and TEM investigation. The interaction of Au NPs, TiO2 NPs, and carbon fabric (CF) to improve electron transport and charge separation on the photocatalyst surface is supported by XPS spectra. TEM and XRD analyses revealed that all TiO2 components in the Au/TiO2 coating layer consisted of anatase having high photocatalytic activity. After comparing the photocatalytic activity of TiO2 and Au/TiO2-coated samples under solar-simulated light and a voltage of 3 V, it was found that the surface coated with Au NPs had a superior photocatalytic effect than the surface coated with only TiO2.
A virtual restoration network of ancient murals via global–local feature extraction and structural information guidance
Authors: Ge Hao , Yu Ying , Zhang Le 
Published: December 2023

Abstract
Ancient murals are precious cultural heritages. They suffer from various damages due to man-made destruction and long-time exposure to the environment. It is urgent to protect and restore the damaged ancient murals. Virtual restoration of ancient murals aims to fill damaged mural regions by using modern computer techniques. Most existing restoration approaches fail to fill the loss mural regions with rich details and complex structures. In this paper, we propose a virtual restoration network of ancient murals based on global–local feature extraction and structural information guidance (GLSI). The proposed network consists of two major sub-networks: the structural information generator (SIG) and the image content generator (ICG). In the first sub-network, SIG can predict the structural information and the coarse contents for the missing mural regions. In the second sub-network, ICG utilizes the predicted structural information and the coarse contents to generate the refined image contents for the missing mural regions. Moreover, we design an innovative BranchBlock module that can effectively extract and integrate the local and global features. We introduce a Fast Fourier Convolution (FFC) to improve the color restoration for the missing mural regions. We conduct experiments over simulated and real damaged murals. Experimental results show that our proposed method outperforms other three comparative state-of-the-art approaches in terms of structural continuity, color harmony and visual rationality of the restored mural images. In addition, the mural restoration results of our method can achieve comparatively high quantitative evaluation metrics.
An MRI-based radiomics nomogram for detecting cervical esophagus invasion in hypopharyngeal squamous cell carcinoma
Authors: Qi Meng , Sha Yan , Zhang Duo , Ren Jiliang 
Published: December 2023

Abstract
Background
Accurate detection of cervical esophagus invasion (CEI) in HPSCC is challenging but crucial. We aimed to investigate the value of magnetic resonance imaging (MRI)-based radiomics for detecting CEI in patients with HPSCC.

Methods
This retrospective study included 151 HPSCC patients with or without CEI, which were randomly assigned into a training (n = 101) or validation (n = 50) cohort. A total of 750 radiomics features were extracted from T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (ceT1WI), respectively. A radiomics signature was constructed using the least absolute shrinkage and selection operator method. Multivariable logistic regression analyses were adopted to establish a clinical model and a radiomics nomogram. Two experienced radiologists evaluated the CEI status based on morphological findings. Areas under the curve (AUCs) of the models and readers were compared using the DeLong method. The performance of the nomogram was also assessed by its calibration and clinical usefulness.

Results
The radiomics signature, consisting of five T2WI and six ceT1WI radiomics features, was significantly associated with CEI in both cohorts (all p < 0.001). The radiomics nomogram combining the radiomics signature and clinical T stage achieved significantly higher predictive value than the clinical model and pooled readers in the training (AUC 0.923 vs. 0.723 and 0.621, all p < 0.001) and validation (AUC 0.888 vs. 0.754 and 0.647, all p < 0.05) cohorts. The radiomics nomogram showed favorable calibration in both cohorts and provided better net benefit than the clinical model.

Conclusions
The MRI-based radiomics nomogram is a promising method for detecting CEI in HPSCC.
Multiparametric bone MRI targeting aides lesion selection for CT-guided sclerotic bone biopsies in metastatic castrate resistant prostate cancer
Authors: Donners Ricardo , Figueiredo Ines , Westaby Daniel , Koh Dow-Mu , Tunariu Nina , Carreira Suzanne , de Bono Johann S. , Fotiadis Nicos 
Published: December 2023

Abstract
Background
Bone biopsies in metastatic castrate-resistant prostate cancer (mCRPC) patients can be challenging. This study’s objective was to prospectively validate a multiparametric bone MRI (mpBMRI) algorithm to facilitate target lesion selection in mCRPC patients with sclerotic bone disease for subsequent CT-guided bone biopsies.

Methods
20 CT-guided bone biopsies were prospectively performed between 02/2021 and 11/2021 in 17 mCRPC patients with only sclerotic bone disease. Biopsy targets were selected based on MRI, including diffusion-weighted (DWI) and T1-weighted VIBE Dixon MR images, allowing for calculation of the apparent diffusion coefficient (ADC) and the relative fat-fraction (rFF), respectively. Bone marrow with high DWI signal, ADC < 1100 µm2/s and rFF < 20% was the preferred biopsy target. Tumor content and NGS-feasibility was assessed by a pathologist. Prognostic routine laboratory blood parameters, target lesion size, biopsy tract length, visual CT density, means of HU, ADC and rFF were compared between successful and unsuccessful biopsies (p < 0.05 = significant).

Results
Overall, 17/20 (85%) biopsies were tumor-positive and next-generation genomic sequencing (NGS) was feasible in 13/18 (72%) evaluated samples. Neither laboratory parameters, diameter, tract length nor visual CT density grading showed significant differences between a positive versus negative or NGS feasible versus non-feasible biopsy results (each p > 0.137). Lesion mean HU was 387 ± 187 HU in NGS feasible and 493 ± 218 HU in non-feasible biopsies (p = 0.521). For targets fulfilling all MRI selection algorithm criteria, 13/14 (93%) biopsies were tumor-positive and 10/12 (83%) provided NGS adequate tissue.

Conclusions
Multiparametric bone MRI can facilitate target lesion selection for subsequent CT-guided bone biopsy in mCPRC patients with sclerotic metastases.

Trial registration
Committee for Clinical Research of the Royal Marsden Hospital registration number SE1220.
Comparing endoscopic ultrasonography and double contrast-enhanced ultrasonography in the preoperative diagnosis of gastric stromal tumor
Authors: He Huiliao , Tang Tingting , Wang Xiaohua , Zhou Lingling , Wang Liang 
Published: December 2023

Abstract
Background
This study was designed to perform a comparative analysis between endoscopic ultrasonography (EUS) and double contrast-enhanced ultrasonography (DCEUS) for the preoperative diagnosis of gastric stromal tumors (GSTs).

Methods
A retrospective study was conducted involving 139 patients with histologically confirmed GSTs. All patients preoperatively underwent DCEUS and EUS. The pathology reports were treated as the baseline and were retrospectively compared with the findings of EUS and DCEUS.

Results
Of the 139 lesions, 120 and 113 were correctly identified by DCEUS and EUS, respectively, with an accuracy of 86.3% and 81.3%. The results revealed an insignificant difference between these two methods (p = 0.189).

Conclusions
DCEUS can display not only the locations, sizes, shapes, borders, internal echoes, but also show the blood perfusion patterns of GSTs. It is a highly accurate, noninvasive, and convenient method to be used at the pre-treatment stage.
Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study
Authors: Evbuomwan Osayande , Engelbrecht Gerrit , Driver Cathryn , Sempa Joseph , van Rensburg Barend Jansen , Labuschagne Mathys , Horn-Lodewyk Je’nine 
Published: December 2023

Abstract
Background
Rheumatoid arthritis (RA) is an inflammatory disease that can lead to progressive joint damage. Early identification of synovitis is key in the management of patients with RA. The aim of this study was to assess synovitis in patients with RA using 99mTc-glucosamine single photon emission computed tomography/computed tomography (SPECT/CT) imaging and compare this radiopharmaceutical's diagnostic performance with ultrasound (US) imaging. This prospective study included 22 participants with active RA and 380 joints were assessed with SPECT/CT and US imaging. SPECT/CT imaging of the joints of interest was performed in each participant three hours after injection of 99mTc-glucosamine, with US imaging of the same joints performed on the same day. The affected joints were qualitatively assessed for 99mTc-glucosamine uptake and compared with the findings on US imaging.

Results
Abnormal increased uptake of 99mTc-glucosamine, localized specifically to the synovial space, was noted in the affected joints. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 99mTc-glucosamine SPECT/CT imaging were 86%, 60%, 61%, 85% and 73%, respectively. A sensitivity of 100% was noted in the identification of synovitis in the carpal and knee joints. Disease activity in the distal interphalangeal (DIP) joints was not observed with either SPECT/CT or US.

Conclusions
SPECT/CT imaging with 99mTc-glucosamine is a valuable tool for assessing disease activity in the joints of patients with RA. It has a very high sensitivity in detecting synovitis and it correlates very well with US imaging in this regard.
Successful Implantation of a Ventricular Shunt With Termination in the Iliac Bone in the Adult Patient With Obstructive Hydrocephalus
Authors: Vivelo Nicole , Krause Katie , Leveque Jean-Christophe A. 
Published: December 2023

BACKGROUND AND IMPORTANCE:
With the exception of the 3 classic shunt placement options (ventriculoperitoneal, ventriculopleural, and ventriculoatrial), surgically feasible alternative sites for distal catheter placement remain limited and often require the assistance of an access surgeon. Tubbs et al suggested the possibility of intraosseous cerebrospinal fluid diversion in the ilium, noting that ilium infusion in cadaveric specimens was possible without the development of body edema or fluid overflow. Since this publication, limited case reports have been published on the success of ventriculo-ilium (VI) shunt placement. Here, we describe the technique used for successful VI shunt placement in 2 adult patients.

CLINICAL PRESENTATION:
Here, we describe 2 patients with differing etiologies of hydrocephalus (obstructive and nonobstructive) and complex medical and surgical problems precluding traditional distal shunt termini. Both patients underwent successful placement of a VI shunt with distal catheter placement into the right iliac crest using a small right-angle connector and small cranial fixation plate to prevent backout of the catheter.

DISCUSSION AND CONCLUSION:
We report the first demonstration of successful placement of a VI shunt in 2 adult patients with evidence of shunt functionality and improved neurological outcome. We propose that the placement of a VI shunt is an easy and viable option when more traditional shunt methods are not available for use.
Haemophilus influenzae epididymo-orchitis and bacteraemia in an immunocompetent patient
Authors: Farouji Abdelhadi , Haddad Ahmad W. , Yar Khan Nibras , Battah Arwa , Ahmad Amaar S. , Slim Jihad 
Published: December 2023

Background: Epididymitis is a common cause of scrotal pain in adults, with coliform bacteria being the most common isolated organisms in patients older than 35. Case presentation: A 51-year-old healthy patient presented with scrotal pain and swelling, and was found to have epididymo-orchitis and bacteraemia caused by Haemophilus influenzae, which has not previously been reported as a cause of epididymo-orchitis and bacteraemia in immunocompetent patients. Discussion: Diagnostic studies can help confirm the diagnosis and detect the causative pathogen. In all suspected cases, a urinalysis, urine culture and a urine or urethral swab for nucleic acid amplification tests (NAATs) for Neisseria gonorrhoeae and Chlamydia trachomatis should be performed. Colour Doppler ultrasonography often shows an enlarged thickened epididymis with increased Doppler wave pulsation in epididymitis. H. influenzae are pleomorphic gram-negative rods that commonly colonise the human respiratory tract and are associated with a number of clinical conditions. H. influenzae has been reported as a cause of epididymo-orchitis in prepubertal boys, and in few cases were associated with positive blood cultures. In adults, H. influenzae has been isolated before from urine samples or urethral swabs in patients with epididymitis or epididymo-orchitis. Conclusion: This case highlights the possibility of H. influenzae causing epididymo-orchitis and bacteraemia in immunocompetent patients. Healthcare providers should consider H. influenzae in the differential diagnosis of epididymitis and epididymo-orchitis in both immunocompetent and immunocompromised patients.
Content comparison of unmet needs self-report measures for lymphoma cancer survivors: A systematic review
Authors: Boland Vanessa , Drury Amanda , Brady Anne-Marie 
Published: December 2023

Purpose
The increasing recognition of the complex impacts of a cancer diagnosis and its treatment has led to efforts to develop instruments to reflect survivors’ needs accurately. However, evidence regarding the content and quality of instruments used to evaluate the unmet needs of lymphoma survivors is lacking. This review aimed to evaluate the psychometric properties and comprehensiveness of available self-report instruments to assess unmet needs and quality of life with adult lymphoma survivors.

Methods
A systematic search of five databases (CINAHL, EMBASE, Medline, PsycInfo and Scopus) was conducted to identify instruments measuring unmet needs or quality of life outcomes. Original articles reporting the instrument’s validation or development via citation screening were retrieved and screened against eligibility criteria. An appraisal of the instrument’s measurement properties was conducted, guided by the COSMIN methodology and reported in accordance with PRISMA guidelines. A content comparison using the Supportive Care in Cancer Framework was performed.

Results
Twelve instruments met the inclusion criteria; only one was explicitly developed for lymphoma (Functional Assessment of Cancer Therapy–Lymphoma). Four instruments focused on the construct of need, and eight focused on quality of life. The psychometric data in the published literature is not comprehensive; there is heterogeneity in their development, content and quality. No included instrument was examined for all COSMIN measurement properties, and methodological quality was variable; all instruments measured at least four domains of need. The emotional domain was reviewed by all instruments (n = 12), and the spiritual and informational domains received the least focus (n = 4 each).

Conclusion
This review provides a platform for instrument comparison, with suggestions for important factors to consider in systematically selecting unmet needs and quality of life self-report measures for adult lymphoma survivors. Considering the various discrepancies and limitations of the available instruments, using more than one instrument is recommended. In selecting measurement instruments, researchers should consider research objectives, study design, psychometric properties and the pros and cons of using more than one measure. Evaluating the participant burden and feasibility of completing the selected instrument is important for lymphoma survivors, a group burdened by cancer-related fatigue and cognitive impairment.
Epidemiology and burden of Severe Acute Respiratory Infections (SARI) in the aftermath of COVID-19 pandemic: A prospective sentinel surveillance study in a Tunisian Medical ICU, 2022/2023
Authors: Boussarsar Mohamed , Ennouri Emna , Habbachi Naima , Bouguezzi Nabil , Meddeb Khaoula , Gallas Salma , Hafdhi Malek , Zghidi Marwa , Toumi Radhouane , Ben Saida Imen , Abid Salma , Boutiba-Ben Boubaker Ilhem , Maazaoui Latifa , El Ghord Hakim , Gzara Ahlem , Yazidi Rihab , Ben Salah Afif 
Published: December 2023

Background
Severe Acute Respiratory Infections (SARI) caused by influenza and other respiratory viruses pose significant global health challenges, and the COVID-19 pandemic has further strained healthcare systems. As the focus shifts from the pandemic to other respiratory infections, assessing the epidemiology and burden of SARI is crucial for healthcare planning and resource allocation. Aim: to understand the impact of the post-pandemic period on the epidemiology of SARI cases, clinical outcomes, and healthcare resource utilization in Tunisia.

Methods
This is a prospective study conducted in a Tunisian MICU part of a national sentinel surveillance system, focusing on enhanced SARI surveillance. SARI cases from week 39/2022, 26 September to week 19/2023, 13 May were included, according to a standardized case definition. Samples were collected for virological RT-PCR testing, and an electronic system ensured standardized and accurate data collection. Descriptive statistics were performed to assess epidemiology, trends, and outcomes of SARI cases, and univariate/multivariate analyses to assess factors associated with mortality.

Results
Among 312 MICU patients, 164 SARI cases were identified during the study period. 64(39%) RT-PCR were returned positive for at least one pathogen, with influenza A and B strains accounting for 20.7% of cases at the early stages of the influenza season. The MICU experienced a significant peak in admissions during weeks 1-11/2023, leading to resource mobilization and the creation of a surge unit. SARI cases utilized 1664/3120 of the MICU-stay days and required 1157 mechanical ventilation days. The overall mortality rate among SARI cases was 22.6%. Age, non-COPD, and ARDS were identified as independent predictors of mortality.

Conclusions
The present study identified a relatively high rate of SARI cases, with 39% positivity for at least one respiratory virus, with influenza A and B strains occurring predominantly during the early stages of the influenza season. The findings shed light on the considerable resource utilization and mortality associated with these infections, underscoring the urgency for proactive management and efficient resource allocation strategies.
In silico analysis of TRPM4 variants of unknown clinical significance
Authors: Tarnovskaya Svetlana I. , Kostareva Anna A. , Zhorov Boris S. 
Published: December 2023

Background
TRPM4 is a calcium-activated channel that selectively permeates monovalent cations. Genetic variants of the channel in cardiomyocytes are associated with various heart disorders, such as progressive familial heart block and Brugada syndrome. About97% of all known TRPM4 missense variants are classified as variants of unknown clinical significance (VUSs). The very large number of VUSs is a serious problem in diagnostics and treatment of inherited heart diseases.

Methods and results
We collected 233 benign or pathogenic missense variants in the superfamily of TRP channels from databases ClinVar, Humsavar and Ensembl Variation to compare performance of 22 algorithms that predict damaging variants. We found that ClinPred is the best-performing tool for TRP channels. We also used the paralogue annotation method to identify disease variants across the TRP family. In the set of 565 VUSs of hTRPM4, ClinPred predicted pathogenicity of 299 variants. Among these, 12 variants are also categorized as LP/P variants in at least one paralogue of hTRPM4. We further used the cryo-EM structure of hTRPM4 to find scores of contact pairs between parental (wild type) residues of VUSs for which ClinPred predicts a high probability of pathogenicity of variants for both contact partners. We propose that 68 respective missense VUSs are also likely pathogenic variants.

Conclusions
ClinPred outperformed other in-silico tools in predicting damaging variants of TRP channels. ClinPred, the paralogue annotation method, and analysis of residue contacts the hTRPM4 cryo-EM structure collectively suggest pathogenicity of 80 TRPM4 VUSs.
Labor of Minors in Industrial of Ukrainian Lands (19th – Early 20th Century)
Authors: Shandra Iryna , Birova Olha 
Published: December 2023

At the present stage, the phrase “labor of minors” sounds alarming and is a sign of the low economic and cultural development of society. For the period of industrialization of the 19th – early 20th century this phenomenon was by no means a rarity, but rather one of the components of economic modernization. The Ukrainian lands were no exception in this regard, child and adolescent labor was used in coal, metallurgical, chemical and other industries.
This study is based on workers’ memories of their teenage years, memories of mining engineers, factory inspectors, public figures, as well as, albeit very scattered, statistics on the employment of minors in industry in the second half of the 19th – early 20th century. The most significant and, in this regard, reflected in the memoirs of participants in the production process, were such aspects of the work of minors as working conditions, wages, “professions” of minors, their employment statistics, the evolution of labor legislation and numerous violations of approved norms. The complex conclusion is that it took a long mutual development of public opinion, legislation and family foundations to eradicate the work of minors in industry.