bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Challenges of International and European Human Rights Law: Introductory Remarks
Authors: Karska Elżbieta , Karski Karol 
Published: November 2023

Abstract
The protection of human rights is one of the most important issues in the modern world and their development is a challenge for all legal systems. Human rights protection is an established fact in international law. This is both an expression of the expectations of the states that have created this system and an instrument designed to see the solutions contained therein incorporated into national legal systems. Human rights are of particular interest on the Old Continent. They have been developed both within the regional system of the Council of Europe and, as ‘fundamental rights’, within the European Union. Human rights are one of those areas where both legally binding instruments and ‘soft law’ acts are adopted. These acts of ‘soft law’ do not formally create legal obligations but they nevertheless affect their addressees, including states, by virtue of the respect given to the entities that adopt them. There are also examples of ‘soft law’ acts having institutional setting and significance with the creation of bodies to monitor their implementation. This paper contains introductory remarks in relation to current issues in the field of international and European human rights law that are presented in this Special Issue of the International Community Law Review (ICLR).
Frege and the Logic of the Historical Proposition
Authors: O’Sullivan Luke 
Published: November 2023

Abstract
This article argues that history played a larger role in the thought of Gottlob Frege than has usually been acknowledged. Frege’s logical writings frequently employed statements about the past as examples that included references to historical persons. Frege also described history as a science and argued that historical propositions could support valid inferences and reliably identify historical persons and events. But Frege’s eternalist theory of reference, designed primarily for formal concepts and objects, struggled to accommodate such propositions. Identifying an objective referent for the subjectivity of historical actors was particularly problematic. The article suggests that Frege’s writings are interesting for the philosopher of history for at least two reasons: first, his work is clarificatory when considering the key features that historical propositions must have to count as objective knowledge, and second, it foreshadowed the issues with historicity that analytical philosophy experienced in the twentieth century. It concludes that the problems Frege raised exposed the need for a new concept of inter-subjectivity to replace his own Platonic foundation for objectivity.
Longitudinal changes in skin perfusion pressure after endovascular therapy in patients with chronic limb-threatening ischemia
Authors: Tokuda Takahiro , Oba Yasuhiro , Kagase Ai , Matsuda Hiroaki , Suzuki Yoriyasu , Murata Akira , Ito Tatsuya , Hirano Keisuke 
Published: November 2023

Purpose The skin perfusion pressure (SPP) increases after endovascular treatment (EVT) for up to 1 month, although changes beyond 1 month remain unreported. This study aimed to investigate the changes in the SPP over time after EVT. Materials and methods This was a single-center, prospective, observational study. We included patients with chronic limb-threatening ischemia who underwent EVT between January 2019 and July 2022. We evaluated the SPP after EVT monthly for up to 3 months and compared the changes in the SPP between patients with different comorbidities. Moreover, we investigated the independent predictors of recurrent foot ischemia using a multivariate analysis. Results Overall, 87 patients were included in the study. The mean preprocedural dorsal and plantar SPP was 33.9 ± 14.7 and 33.4 ± 13.1 mmHg, respectively. After the procedure, the SPP significantly increased at 1 month but decreased during months 2 and 3 (the dorsal SPP at 1, 2, and 3 months was 59.6 ± 20.3, 48.3 ± 20.9, and 39.7 ± 14.7, respectively, p < 0.01; the plantar SPP at 1, 2, and 3 months was 57.3 ± 18.2, 48.2 ± 15.6, and 40.5 ± 15.3, respectively, p < 0.01). Changes in the SPP did not differ among patients with different comorbidities. The multivariate analysis revealed that severe infrapopliteal calcification was an independent predictor of recurrent foot ischemia (odds ratio, 3.8; 95% confidence interval, 1.1–13.4; p = 0.04). Conclusion The SPP after EVT significantly increased at 1 month and decreased monthly for up to 3 months. Severe infrapopliteal calcification was the sole predictor of foot ischemia recurrence. Meticulous follow-up after EVT and regular hemodynamic examinations are important.
Goal-focused abusive leaders: The mitigating role of conscientiousness in subordinates’ counterproductive work behavior
Authors: Joo Min-Kyu , Yu Jia , Atwater Leanne 
Published: November 2023

When an abusive supervisor exhibits goal-focused leadership, does goal-focused leadership buffer or deteriorate the impact of abusive supervision on subordinates? Although leaders normally exhibit different leadership styles at the same time, little effort has been made to examine how different leadership styles affect subordinates. We also investigate the three-way interaction among abusive supervision, goal-focused leadership, and conscientiousness on counterproductive work behavior (CWB). With two multinational samples, our findings consistently indicate that subordinates exposed to more goal-focused leadership along with abusive supervision are significantly more likely to engage in CWB. In addition, we find a three-way interaction such that the relationship between abusive supervision and subordinates’ CWB is the strongest among subordinates who have low conscientiousness when leaders exhibit a high level of goal-focused leadership. JEL Classification: D23
Primary care outreach and decision counseling for lung cancer screening
Authors: Bittner Fagan Heather , Jurkovitz Claudine , Zhang Zugui , Thompson L Anna , Patterson Freda , Zazzarino Martha A , Myers Ronald E 
Published: November 2023

Introduction Lung cancer screening rates are very low despite a level B recommendation from the United States Preventive Services Task Force since 2013 and clear evidence that lung cancer screening reduces mortality. The Center for Medicare and Medicaid Services requires shared decision-making (SDM) for lung cancer screening reimbursement. The objective of this study was to determine the effect of an SDM intervention on lung cancer screening in primary care. Methods The study design was a single-arm clinical trial design. The intervention included phone contact outside of a primary care visit and the use of the Decision Counseling Program ®, an online interactive decision aid focused on determining the factors which influence patients to screen or not screen, prioritizing those factors, and determining a decision preference score. The primary outcome was the completion of low-dose computed tomography scan (LDCT) 1 year after the SDM session compared in participants versus nonparticipants. Results From six practices, there were 1359 potentially eligible patients in electronic medical record data, and 336 were reached to assess eligibility criteria. A total of 80 patients consented to be in the study, 64 completed a decision counseling session and 16 did not complete a session. Among the 64 people who agreed to have decision counseling, 45% had LDCT, higher than typically seen in routine clinical practice. Although not a comparable group, among the 16 people who declined decision counseling, none had LDCT. Conclusions Decision counseling is a promising intervention that might support SDM in the context of improving uptake of lung cancer screening in primary care. However, further, larger studies are needed.
The Antitumor Impact of Combining Hepatic Artery Ligation With Copper Chelators for Liver Cancer
Authors: Zeng Ni , Wang Ye , Wan Yuan , Wang Hongyu , Li Nan 
Published: November 2023

Background: Hepatocellular carcinoma (HCC) is one of the main cancer-related mortality worldwide. Thus, there is a constant search for improvement in treatment strategies to enhance the prognosis of this malignancy. The study aims to investigate the combined antitumor activity of ammonium tetrathiomolybdate (TM, copper chelator) combined with hepatic artery ligation (HAL) for liver cancer. Methods: A total of 40 Sprague-Dawley (SD) rats bearing hepatic tumors were randomly divided into four groups: the control group without any treatment (control), HAL only (HAL), given TM by gavage (TM), and given TM combined with HAL (HAL + TM). The concentrations of serum copper were measured at the predetermined time points. Tumor growth rate, overall survival (OS), expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), and microvessel density (MVD), as determined by immunohistochemical examination, were compared. Results: HAL treatment transiently could elevate alanine transaminase (ALT) and aspartate transaminase (AST) but resumed to baseline within 1 week. Serum copper was significantly increased in tumor-bearing animals over time. The values of serum copper in the three treatment groups were significantly lower than those in the control group at different time points, with the lowest values observed in the TM group ( P < .05). The average tumor size was 30.33 ± 2.58, 20.83 ± 2.93, 16.80 ± 3.84, and 10.88 ± 1.08 mm in the control, HAL, TM, and HAL + TM groups, respectively (HAL + TM vs other groups, all P < .05). In addition, the expression levels of HIF-1α, VEGF, and MVD were significantly lower in the HAL + TM group than those in the other groups ( P < .05). The OS of rats in the combined groups was significantly prolonged combined to the other groups ( P < .05), with survival time of 19.1 ± 0.64, 25.4 ± 1.24, 25.3 ± 1.78, and 29.9 ± 2.22 days in the control, HAL, TM, and HAL + TM groups, respectively. Conclusion: These findings suggest that combined treatment with TM and HAL holds great potential for liver cancer treatment by reducing tumor hypoxia and angiogenesis. The observed results indicate that these combinations may offer a novel target and strategy for interventional therapy of liver cancer.
Exploring predictors of perceived stress: a cross-sectional study among nursing students during their clinical practice
Authors: Sarfika Rika , Wenny Bunga Permata , Muliantino Mulyanti Roberto , Novrianda Dwi , Saifudin I Made Moh. Yanuar 
Published: November 2023

Background: Clinical practice is a demanding academic activity for nursing students, and a variety of factors can affect this perception. This study aimed to investigate the predictors of perceived stress among Indonesian nursing students during their clinical practice. Methods: From September to November 2022, this cross-sectional investigation was carried out. Five questionnaires, including the socio-demographic, the PSS, the GHQ, the CBI, the MSPSS and the RSES, were completed by 208 participants. With significance set to p < 0.05, the Pearson correlation and multiple linear regression analysis were carried out. Results: Coping strategies ( r = 0.20, p < 0.01), overall health ( r = 0.50, p < 0.01), social support ( r = −0.34, p < 0.01) and self-esteem ( r = −0.51, p < 0.01) were all substantially linked with perceived stress. Furthermore, age (β = −0.22, p < 0.001), coping style (β = 0.22, p < 0.001) and self-esteem (β = −0.42, p < 0.001) substantially predicted perceived stress among nursing students. Conclusion: The study’s findings revealed strong relationships between perceived stress and general health, coping mechanisms, self-esteem and social support. These results can be utilised as evidence to help educators and other stakeholders develop programmes that effectively manage stress among nursing students during their clinical rotations.
Surgical versus medical castration in the treatment of metastatic prostate cancer: A systematic review and meta-analysis
Authors: O’Sullivan Niall J , Temperley Hugo C , Davey Matthew G , Naughton Ailish , Casey Rowan G 
Published: November 2023

Introduction: Metastatic disease is found in up to 20% of prostate cancer (PCa) cases at diagnosis. Since their introduction in the 1980s, long acting gonadotropin-releasing hormone (GnRH) analogues, administered subcutaneously or intramuscularly every 1–6 months have widely replaced bilateral orchidectomy as the method of castration for this cohort of patients. Recent evidence suggests that surgical castration confers a superior side-effect profile and cost. We aimed to perform a systematic review and meta-analysis to compare these two treatment methods particularly in terms of survival, side-effect profile and cost-effectiveness. Methods: A systematic review of the literature was performed for studies comparing medical and surgical castration for metastatic PCa. Outcome measurements included overall survival, side-effect profile and cost. Results: Fifteen studies on 63,682 participants ( n = 59,045 for medical and n = 4637 for surgical) met inclusion criteria. Our analysis demonstrated a trend towards significance in overall survival rates in favour of surgical castration (hazard ratio = 0.89, 95% confidence interval (CI) = 0.79 to 1.01, p = 0.06), a trend towards significance in cardiovascular complications in favour of the surgical group (odds ratio (OR) = 0.79, 95% CI = 0.62 to 1.00, p = 0.05) and a significantly lower nadir prostate-specific antigen (PSA) level in favour of medical castration (MD PSA 1.17 less in medical castration group, 95% CI = 0.67 to 1.67, p < 0.01). Conclusion: Surgical castration appears to be a safe, feasible and efficacious alternative to medical castration, with evidence to suggest a potential survival benefit and limited evidence of a financial benefit in the treatment of men with metastatic PCa. Further studies are required to further quantify the financial burden of one method over another, as well as to identify which subgroup of patients respond best to each method of castration. Level of evidence: Level 1
Effect of the Copenhagen Achilles Rupture Treatment Algorithm (CARTA) on Calf Muscle Volume and Tendon Elongation After Acute Achilles Tendon Rupture: A Predefined Secondary Analysis of the First 60 Patients in a Randomized Controlled Trial
Authors: Barfod Kristoffer Weisskirchner , Overgård Anders Brøgger , Hansen Maria Swennergren , Haddouchi Ibrahim El , Toft Marianne , Hölmich Per 
Published: November 2023

Background: Surgical treatment of acute Achilles tendon rupture (ATR) lowers the risk of rerupture and may reduce calf atrophy and elongation of the Achilles tendon. The Copenhagen Achilles Rupture Treatment Algorithm (CARTA) was developed to provide individualized treatment selection based on ultrasonographic evaluation of the rupture. Purpose: In a randomized setup, the present study aimed to investigate whether treatment selection using the CARTA could reduce atrophy and tendon elongation compared with (1) patients treated surgically and (2) patients treated nonsurgically. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 60 patients with an acute ATR were randomly assigned to receive treatment based on the CARTA (intervention), surgical treatment (control), or nonsurgical treatment (control) in a 1 to 1 to 1 ratio. After 1 year, magnetic resonance imaging of both calves was performed, and muscle volume and Achilles tendon length were measured. Results were presented as the ratio between the affected and the unaffected limbs (ie, limb symmetry index; %). Results: A total of 156 patients were assessed for eligibility, 60 patients were randomized, and 54 patients provided data for the study—19 patients received treatment based on the CARTA (intervention group), 17 patients received nonsurgical treatment (control), and 18 patients received surgical treatment (control). No statistically significant differences were found between the intervention group and the 2 control groups regarding muscle volume and tendon length. No statistically significant differences were found between patients treated surgically and patients treated nonsurgically. Comparison between the affected and the unaffected limb showed statistically significant muscle atrophy (24%-30%) and tendon elongation (soleus, 59%-76%; gastrocnemius, 8%-14%) in the affected limb in all 3 groups. Conclusion: Individualized treatment of acute ATR using an ultrasonographic selection algorithm did not reduce calf muscle atrophy or tendon elongation when compared with surgical and nonsurgical treatment. Surgical treatment did not reduce calf muscle atrophy or tendon elongation compared with nonsurgical treatment.
Evaluation of flexural strength, degree of conversion, and demineralization-prevention properties in adjacent tooth structures of an experimental fissure sealant containing nano-calcium-phosphate compounds
Authors: Fallahzadeh Farnoosh , Pirmoradian Maryam , Ghasemi Solmaz Mohammadzadeh , Mortazavi Maryam 
Published: November 2023

Abstract
Background
The present study aimed to evaluate the flexural strength, degree of conversion, and demineralization-prevention ability of an experimental fissure sealant containing nano-calcium-phosphate compounds.

Methods
An experimental sealant was formulated using silica and nano hydroxyapatite filler particles. The control group consisted of the DENU Seal (n = 10, each group). The flexural bond strength was evaluated by UTM. DC was evaluated by FTIR. To evaluate the demineralization-prevention ability, Cl V cavities in 10 third molar teeth restored with two sealant products, followed by an acid challenge then the Vickers microhardness test was carried out.

Results
The mean flexural strength in the commercial group was higher than the experimental group. However, the mean flexural modulus was not significantly different between the two groups. In the experimental group, DC was significantly higher than the commercial group. Adjacent to the interface, the decrease in microhardness in the experimental group was significantly less than the commercial group. However, on the tooth surface, there were no significant differences between the two groups. In the experimental group, the decrease in microhardness at the interface was less than at the tooth surface, however the situation was opposite in the commercial group.

Conclusions
Incorporating hydroxyapatite into the sealant structure might prevent demineralization, without adverse effects on flexural modulus and degree of conversion.
Communication strategies used by medical physicians when delivering bad news at the Maputo Central Hospital, Mozambique: a cross-sectional study
Authors: Schmauch Natália Ubisse , Pinto Emilia , Rego Francisca , Castro Luísa , Sacarlal Jahit , Rego Guilhermina 
Published: November 2023

AbstractBackgroundPhysicians’ communication with patients and their families is important during both the disease diagnosis and prognosis stages and through the follow-up process. Effective physician communication improves patients’ quality of life and satisfaction with care and helps reduce suffering for those newly diagnosed with advanced progressive illnesses. This study aims to identify the communication strategies physicians use in the transition to palliative care and how these professionals perceive their academic and clinical preparation concerning this task.MethodsA cross-sectional and quantitative study. Physicians providing palliative care at the Maputo Central Hospital, Mozambique, were invited to complete a 17-question questionnaire. This questionnaire was based on a Brazilian adaptation of the Setting-Perception-Invitation-Knowledge-Emotions-Strategy (SPIKES) tool, the P-A-C-I-E-N-T-E protocol, with additional questions regarding socio-demographic details and the integration of “communication of bad news” into hospital training.ResultsOf the 121 participants, 62 (51.2%) were male, and 110 (90.9%) were general practitioners, with a median age of 36 years old. They had worked in clinical practice for a median of 8 years and in their current department for three years. The majority of the participants considered that they have an acceptable or good level of bad news communication skills and believed that they do it in a clear and empathic way, paying attention to the patient’s requests and doubts; however, most were not aware of the existing tools to assist them in this task and suggested that delivering bad news ought to be integrated into the undergraduate medical course and included in hospital training.ConclusionsThis study adds to our understanding of physicians’ strategies when communicating bad news in the context of palliative care at one Mozambique hospital. As palliative care is not fully implemented in Mozambique, it is important to use protocols suitable to the country’s healthcare level to improve how doctors deal with patients and their family members.
Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis
Authors: Yang Tao , Chen Weiwei , Gan Kai , Wang Chaofeng , Xie Xiaoxiao , Su Yuangang , Lian Haoyu , Xu Jiake , Zhao Jinmin , Liu Qian 
Published: November 2023

Abstract
Background
Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteoclast differentiation, and mitochondrial reactive oxygen species are closely associated with the differentiation of osteoclasts. Myrislignan (MRL), a natural product derived from nutmeg, has multiple pharmacological activities; however, its therapeutic effect on osteoporosis is unclear. Here, we investigated whether MRL could inhibit osteoclastogenesis and bone mass loss in an ovariectomy mouse model by suppressing mitochondrial function and ERK signaling.

Methods
Tartrate-resistant and phosphatase (TRAP) and bone resorption assays were performed to observe the effect of MRL on osteoclastogenesis of bone marrow macrophages. MitoSOX RED and tetramethyl rhodamine methyl ester (TMRM) staining was performed to evaluate the inhibitory effect of MRL on mitochondria. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assay was performed to detect whether MRL suppressed the expression of osteoclast-specific genes. The impact of MRL on the protein involved in the mitogen-activated protein kinase (MAPK) and nuclear factor-κB pathways was evaluated using western blotting. In addition, a specific ERK agonist LM22B-10, was used to revalidate the inhibitory effect of MRL on ERK. Finally, we established an ovariectomy mouse model to assess the therapeutic effect of MRL on osteoporosis in vivo.

Results
MRL inhibited osteoclast differentiation and the associated bone resorption, by significantly decreasing osteoclastic gene expression. Mechanistically, MRL inhibited the phosphorylation of ERK by suppressing the mitochondrial function, thereby downregulating the nuclear factor of activated T cells 1 (NFATc1) signaling. LM22B-10 treatment further verified the targeted inhibition effect of MRL on ERK. Microscopic computed tomographic and histologic analyses of the tibial tissue sections indicated that ovariectomized mice had lower bone mass and higher expression of ERK compared with normal controls. However, MRL treatment significantly reversed these effects, indicating the anti-osteoporosis effect of MRL.

Conclusion
We report for the first time that MRL inhibits ERK signaling by suppressing mitochondrial function, thereby ameliorating ovariectomy-induced osteoporosis. Our findings can provide a basis for the development of a novel therapeutic strategy for osteoporosis.