bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análises de complicações hospitalares em pacientes pós síndrome coronarianas agudas
Authors: Seleme Vinícius Bocchino , Cabrera Guilherme , Précoma Marina Massuchin , Ghislandi Gabriel Spengler , Bizetto André Luiz Cristani , Bengtsson Eloisa Gôngora , Kotzias Maria Eduarda Tarta 
Published: January 2025

Fundamentos: Este estudo tem como objetivo avaliar as complicações hospitalares de pacientes com síndrome coronariana aguda (SCA) entre os anos de 2016 a 2021 em hospital terciário na cidade de Curitiba, Paraná. Métodos: Trata-se de um estudo tipo retrospectivo com desenho observacional, transversal que envolve a análise de prontuários de pacientes adultos, que tiveram SCA em uso de pelo menos um antiagregante plaquetário, internados em hospital terciário da cidade de Curitiba, PR. Dentro da data prevista foram incluídos 379 pacientes no estudo. Os dados encontrados foram correlacionados entre si para definirmos as principais complicações e os principais desfechos secundários. Resultados: O estudo mostrou que dentre os 379 pacientes avaliados 65% dos pacientes eram hipertensos, 69% não tinham histórico de tabagismo e 44% tinham dislipidemia. Todos os pacientes estavam em uso de AAS. 308 indivíduos utilizaram o clopidogrel como segundo antiagregante plaquetário de escolha e apenas 1 paciente fez uso do prasugrel. Quanto aos diagnósticos, 172 pacientes (45%) foram diagnosticados com infarto agudo do miocárdio sem supra do segmento ST (IAMSSST), seguido de 99 (26%) com infarto agudo do miocárdio com supra do segmento ST (IAMCSST), 64 (17%) angina instável de moderado/alto risco, 44 (12%) angina instável de baixo risco. Após mais de um ano da alta do internamento inicial por SCA, o fato do paciente ter doença multiarterial coronariana, com necessidade de realização de nova angioplastia pós internamento por SCA, esteve associado a mortalidade por causa cardíaca (após mais de 1 ano da alta), com valor de p com relevância estatística (p = 0,002). E, por fim, os pacientes que tiveram alguma complicação na internação tiveram mais óbito por causa cardíaca (p= 0,003). O uso do AAS esteve associado a redução de mortalidade cardíaca após 1 ano do evento, com valor estatístico marginal (p=0,08). Discussão: As doenças multiarteriais coronárias representam maior complexidade anatômica e maiores desafios terapêuticos, o que reflete no aumento da mortalidade. Além disso, as complicações como hemorragia digestiva alta (HDA), choque séptico, choque cardiogenico, acidente vascular isquemico ou hemorragico aumentam o tempo de internamento e aumentam também a necessidade do paciente receber cuidados da unidade de terapia intensiva (UTI) e, com consequente aumento da mortalidade desses pacientes. Conclusão: Apesar do uso de ticagrelor ou prasugrel estarem relacionados a menores complicações isquêmicas, o clopidogrel ainda continua sendo muito utilizado. A presença de complicações durante o internamento impacta em aumento de mortalidade. A análise mostrou que a maioria dos pacientes recebeu tratamento com angioplastia coronariana primária ao invés de trombólise, refletindo uma eficácia no atendimento primário em Curitiba.
Effect of Sequential, Colocalized Radiofrequency and Pulsed Field Ablation on Cardiac Lesion Size and Histology
Authors: Verma Atul , Maffre Jennifer , Sharma Tushar , Farshchi-Heydari Salman 
Published: January 2025

BACKGROUND:
Sequential application of radiofrequency with pulsed field (PF) ablation may increase lesion depth while preserving the advantages of PF. The study’s aim was to determine lesion dimensions of sequential, colocalized radiofrequency and PF ablation.

METHODS:
A preclinical study using swine (n=4) performed lesions in the right/left ventricles. Ablations were performed with a force-sensing 3.5-mm irrigated-tip ablation catheter using a generator delivering both radiofrequency and PF. PF was delivered using unipolar, biphasic pulses at a standard dose (PF index, 300) with 4-mL/min irrigation. Radiofrequency was delivered at 50 W for 10 s (15 mL/min). Lesions were created by applying colocalized radiofrequency followed by sequential application of PF on the same location, PF followed by sequential application of radiofrequency on the same location, PF alone, or radiofrequency alone. Tissue was collected after 2 hours for lesion assessment. Results are mean±SD.

RESULTS:

Forty-five lesions were analyzed. The lesion depth of radiofrequency alone was 4.9±0.8 mm. The mean lesion depth and width for PF alone were 3.5±0.6 and 5.1±1.8 mm. Lesion depths for combined applications were significantly greater versus PF alone (6.2±1.8 mm radiofrequency followed by sequential application of PF on the same location; 5.7±1.3 mm PF followed by sequential application of radiofrequency on the same location;
P
<0.0001 for both). Lesion widths were also significantly greater with combined therapy versus PF alone (8.6±1.8 mm radiofrequency followed by sequential application of PF on the same location; 8.9±2.1 mm PF followed by sequential application of radiofrequency on the same location;
P
<0.0001 for both). Histology for both combined lesions showed central thermal necrosis surrounded by a hemorrhagic and transitional PF zone.

CONCLUSIONS:
Combined, colocalized radiofrequency and PF, irrespective of order, show significantly increased lesion size compared with the same dose of PF or radiofrequency alone.
Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy
Authors: Butters Alexandra , Arnott Clare , Sweeting Joanna , Claggett Brian , Cuomo Anna SE. , Abrams Dominic , Ashley Euan A. , Day Sharlene M. , Helms Adam S. , Lampert Rachel , Lin Kim Y. , Michels Michelle , Miller Erin M. , Olivotto Iacopo , Owens Anjali , Parikh Victoria N. , Pereira Alexandre C. , Rossano Joseph W. , Ryan Thomas D. , Saberi Sara , Stendahl John C. , Ware James S. , Atherton John , Semsarian Christopher , Lakdawala Neal K. , Ho Carolyn Y. , Ingles Jodie 
Published: January 2025

BACKGROUND:
Females with hypertrophic cardiomyopathy present at a more advanced stage of the disease and have a higher risk of heart failure and death. The factors behind these differences are unclear. We aimed to investigate sex-related differences in clinical and genetic factors affecting adverse outcomes in the Sarcomeric Human Cardiomyopathy Registry.

METHODS:
Cox proportional hazard models were fit with a sex interaction term to determine if significant sex differences existed in the association between risk factors and outcomes. Models were fit separately for females and males to find the sex-specific hazard ratio (HR).

RESULTS:

After a mean follow-up of 6.4 years, females had a higher risk of heart failure (HR, 1.51 [95% CI, 1.21–1.88];
P
=0.0003) but a lower risk of atrial fibrillation (HR, 0.74 [95% CI, 0.59–0.93];
P
<0.0001) and ventricular arrhythmia (HR, 0.60 [95% CI, 0.38–0.94];
P
=0.027) than males. No sex difference was observed for death (
P
=0.84). Sarcomere-positive males had higher heart failure (HR, 1.34 [95% CI, 1.06–1.69]) and death risks (HR, 1.48 [95% CI, 1.08–2.04]) not seen in females (HR, 0.85 [95% CI, 0.66–1.08] versus HR, 0.86 [95% CI, 0.71–1.21]).
MYBPC3
variants lowered heart failure risk in females (HR, 0.56 [95% CI, 0.41–0.77]) but not in males (HR, 1.29 [95% CI, 0.99–1.67]). A sex difference appeared in moderate (4% to <6%) versus low risk (<4%) European Society of Cardiology hypertrophic cardiomyopathy risk score, with females at moderate risk more prone to ventricular arrhythmia (HR, 3.57 [95% CI, 1.70–7.49]), unobserved in males (HR, 1.13 [95% CI, 0.63–2.03]).

CONCLUSIONS:
We found that clinical and genetic factors contributing to adverse outcomes in hypertrophic cardiomyopathy affect females and males differently. Thus, research to inform sex-specific management of hypertrophic cardiomyopathy could improve outcomes for both sexes.
Prevalence of High-Risk CTA-Based Carotid Plaque-RADS Subtypes in Patients With Embolic Stroke of Undetermined Source
Authors: Song Jae W. , Phi Huy Q. , Koneru Manisha , Cao Quy , Rubin Jeremy , Sakai Yu , Ibrahim Lamya , Zhou Sonya E. , Woo John H. , Kasner Scott E. , Saba Luca , Cucchiara Brett L. 
Published: January 2025

BACKGROUND:
A modified computed tomography angiography (CTA)–based Carotid Plaque Reporting and Data System (Plaque-RADS) classification was applied to a cohort of patients with embolic stroke of undetermined source to test whether high-risk Plaque-RADS subtypes are more prevalent on the ipsilateral side of stroke. With the widespread use of CTA for stroke evaluation, a CTA-based Plaque-RADS would be valuable for generalizability.

METHODS:

A retrospective observational cross-sectional study was conducted at a single integrated health system comprised of 3 hospitals with a comprehensive stroke center between October 1, 2015, and April 1, 2017. Patients with unilateral anterior circulation stroke and <50% carotid stenosis on CTA were retrospectively identified. Maximum plaque thickness and ulceration were assessed by a neuroradiologist blinded to the stroke side. A semiautomated segmentation software measured intraplaque hemorrhage volumes. Modified CTA-based Plaque-RADS classification was defined as (1) no plaque, (2) plaque thickness <3 mm, (3) plaque thickness ≥3 mm or ulcerated, and (4) plaque with intraplaque hemorrhage >50 mm
3
irrespective of plaque thickness. High-risk plaque subtypes (Plaque-RADS 3 and 4) were compared with low-risk subtypes (Plaque-RADS 1 and 2).

RESULTS:

Ninety-four patients (55% women; median age, 66 years) were included. CTA-based Plaque-RADS categories for plaques ipsilateral to the stroke side were as follows: (1) 14.9%, (2) 42.6%, (3) 41.5%, and (4) 1.1%. Carotid plaques contralateral to stroke side were Plaque-RADS: (1) 21.3%, (2) 46.8%, (3) 31.9%, and (4) 0%. When compared with the contralateral side, plaques ipsilateral to the stroke side were significantly associated with high-risk Plaque-RADS subtypes in a mixed-effects logistic model adjusting for age and sex (adjusted odds ratio, 2.10 [95% CI, 1.20–3.71];
P
=0.01).

CONCLUSIONS:
Carotid plaque ipsilateral to the stroke side was significantly associated with CTA-based high-risk Plaque-RADS subtypes in an embolic stroke of undetermined source cohort. A CTA-based Plaque-RADS classification may be useful for identifying potentially causative carotid plaque phenotypes in patients with embolic stroke of undetermined source.
Edgard Varèse's Poème Électronique: From the Sketches to the Sound Spatialization
Authors: Izzo Leo 
Published: January 2025

Abstract
The article explores the genesis of Poème électronique by Edgard Varèse, drawing on previously unknown or overlooked sources recently identified in the Varèse collection at the Paul Sacher Stiftung (Basel). These sources fall into two categories: (1) Varèse's musical manuscripts and sketches, and (2) the technical plan for the sound spatialization of the entire piece, developed by Philips engineers. Varèse's sketches and drafts for Poème électronique have long been neglected, and the complete spatialization plan, once thought lost, has only recently been rediscovered. These findings shed light on a largely unrecognized, complex creative process that spanned from the initial musical sketches to the final performance within the Philips Pavilion at the Brussels Expo in 1958, a building for which Le Corbusier was commissioned and which his assistant Iannis Xenakis designed.
A focal point of this study is a short section of the piece, labeled by Varèse as section F, which serves as a case study. Varèse composed this section by integrating diagrams for electronic sounds with conventional scores, including fragments from his unpublished Étude pour Espace (1947a). The spatialization plan for section F, in alignment with Varèse's manuscripts, evokes vertical sound movements reminiscent of falling drops. The article offers a formal analysis of Poème électronique based on these drafts and the control score for sound spatialization.
Achieving Middle-Income Status by 2025
Authors: Tiwari Chandani , Das Arpan 
Published: January 2025

Abstract
The economy of Ethiopia has been ranked among the fastest-growing in the world, but its development has trailed. The nation continues to be among the poorest in the world, with a gross national income (GNI) of USD 960 per capita and high levels of inequality. Its rapid population expansion of 2.5 % annually is one of the major obstacles to its development, straining resources and making it challenging to produce enough jobs to accommodate the expanding workforce. Despite these obstacles, Ethiopia has advanced significantly recently. The government has implemented several measures to enhance the economic climate and attract foreign investment. This study focuses on the statistical possibility of Ethiopia reaching middle-income status by the end of 2025. It conducts a variance autoregression model analysis to determine the variables affecting Ethiopia’s GNI per capita and forecasts the GNI per capita through the CAGR method. Forecasting showed higher chances for the nation to reach middle-income status by 2025.
Increasing Agricultural Productivity with Targeted Extension and Advisory Services: Lessons from Ugandan Dairy Farming
Authors: Ahikiriza Elizabeth , Van Huylenbroeck Guido , Lauwers Ludwig 
Published: January 2025

Abstract
Recently, the use of improved technologies and increasing technical efficiency have been considered the two major pathways to sustainably increase agricultural productivity. The main aim of this study was to explore which factors might facilitate the designing of more-targeted extension and advisory services (eas) that can reduce technical inefficiencies, increase farmers’ knowledge about new agricultural technologies and stimulate their intention to use them.1 Mixed research methods, i.e. surveys, key informant interviews and focus group discussions, were used to collect data. Multivariate analysis, structural equation modelling and non-parametric efficiency analysis techniques were the major data analysis methods used to achieve the objectives of this study. The results reveal that Ugandan dairy farmers operate within various production systems, and that they have a low rate of adoption of information and communication technology (ict) in agriculture and a high level of technical inefficiencies. Although targeted eas could result in considerable improvement in their productivity, it should be noted that farmer classification and eas targeting should not be a one-off activity.
Recent extreme cold waves are likely not to happen again this century
Authors: Ribes Aurélien , Robin Yoann , Tessiot Octave , Cattiaux Julien 
Published: January 2025

Abstract
As the climate warms, cold waves are expected to become less intense and less frequent. Is there still a risk of reliving events comparable to the most intense cold spells we can remember? We analyze four remarkable cold spells that have occurred since 2010 in different regions: Western Europe, Texas, China, Brazil. We show that all these recent events have a moderate to high probability of not happening again by 2100 – typically 50% to 90% in an intermediate emissions scenario, depending on the event. The probabilities are even higher for iconic events of the 20th century or earlier. Our results suggest that the most intense cold snaps, and their associated icy landscapes in mid-latitude regions, are disappearing or have already disappeared due to anthropogenic climate change.
Piriformis muscle abnormalities in sacroiliac MRI of patients with axial spondyloarthritis
Authors: Erol Kemal , Akyildiz Tezcan Ezgi , Erol Seyit 
Published: January 2025

Background Piriformis syndrome, an often-overlooked cause of sciatica, commonly presents as chronic gluteal pain and poses a diagnostic challenge, particularly in patients with axial spondyloarthritis (axSpA). Purpose To examine piriformis muscle abnormalities on sacroiliac magnetic resonance imaging (MRI) and their association with clinical outcomes in patients with axSpA. Material and Methods This cross-sectional study included 100 axSpA patients (50 radiographic [r-axSpA], 50 non-radiographic [nr-axSpA]), classified by the 2009 ASAS Axial Spondyloarthritis criteria, who underwent MRI evaluations of the sacroiliac joints over a 6-month period. Piriformis evaluation included the measurement of muscle size, signal intensity, and the assessment of fatty infiltration. Sciatic neuritis was assessed by identifying enlarged sciatic nerves or increased signal intensity. Data collection included demographic details, disease activity, and functionality parameters. Statistical analysis was performed using appropriate methods, with P < 0.05 indicating significance. Results Piriformis syndrome findings were identified in 10% of patients, with a slightly higher incidence in r-axSpA patients (12%) compared to nr-axSpA patients (8%); however, this difference was not statistically significant ( P = 0.739). Patients with these MRI findings had significantly higher disease activity, as indicated by the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (3.5 vs. 2.82; P = 0.015), and greater functional impairment, measured by the Bath Ankylosing Spondylitis Functional Index (5.45 vs. 2.7; P = 0.041). Conclusion This study highlights the presence of MRI findings associated with piriformis syndrome among axSpA patients, which are linked to increased disease activity and reduced function. Recognizing piriformis syndrome as a co-morbidity may improve diagnosis and treatment, leading to better patient outcomes.
High FGF18 expression levels predict poor prognosis in endometrial carcinoma patients and promote tumor growth and metastasis
Authors: Lei Zheng-Yao , Wu Jian , Zhang Bao-Hua , Xiang Wei , Wang Min , Li Bin-bin , Dai Ming-Cheng 
Published: January 2025

Objective To investigate if fibroblast growth factor 18 (FGF18) expression plays an important role in endometrial carcinoma (EC). Methods The clinicopathological associations and prognostic value of FGF18 expression were retrospectively analyzed in 190 patients with EC. FGF18 expression was stably knocked down in EC cell lines. Changes in cell proliferation, migration, and invasion rates were examined via cell behavior experiments. Tumor growth was investigated using a xenograft mouse model. RNA sequencing (RNA-seq) was performed to identify differentially expressed genes (DEGs) in HEC-1-B cells after FGF18 knockdown, followed by pathway enrichment analysis of the DEGs. Results High FGF18 expression levels were closely correlated with EC clinicopathological features, such as histological subtype, FIGO stage, depth of myometrial invasion, and tumor size. Moreover, EC patients with high FGF18 expression levels had poorer overall survival. FGF18 knockdown in EC cells revealed its role in promoting tumor cell proliferation, migration, and invasion in vitro, as well as tumor growth in vivo. RNA-seq of HEC-1-B cells revealed that the DEGs were enriched in signaling pathways related to cell proliferation and migration. Conclusions Overexpression of FGF18 may serve as a prognostic biomarker for EC patients and is a potential therapeutic target for treating this disease.
Relationship of perfluoroalkyl chemicals with chronic obstructive pulmonary disease: A cross-sectional study
Authors: Li Xuefang , Li Zhijun , Ye Jian , Ye Wu 
Published: January 2025

Perfluoroalkyl chemicals are one of the most stable substances in industry and have become ubiquitous contaminants owing to their persistence in the environment. This study enrolled 1,953 participants aged ≥40 years old using data from the National Health and Nutrition Examination Survey (NHANES). We selected four perfluoroalkyl chemicals with a detection frequency of more than 80%, including perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonic acid (PFOS). Multivariate logistic regression was performed to determine the relationship of serum perfluoroalkyl chemicals with COPD and airflow limitation. We evaluated the interaction between perfluoroalkyl chemicals and lung function using multivariate linear regression analyses. Our results showed that the prevalence of COPD was not significantly related to serum PFHxS, PFNA, PFOA, and PFOS. Airflow limitation was positively linked with serum PFHxS, PFOA, and PFOS. However, these significant differences were not robust after adjustment of all confounders of interest. Serum PFHxS, PFOA, and PFOS were all positively related to the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF). However, only PFOA remained significantly linked with the FEV1 and FVC after covariate adjustment. These results indicated that there was no significant interaction between exposure to perfluoroalkyl chemicals and the prevalence of COPD. Higher levels of serum PFOA appeared to be related to higher measures of FEV1 and FVC.
Effect of telemental health adoption on mental health services utilization in federally qualified health centers
Authors: Gadag Khyathi , Arora Kanika , Zahnd Whitney E 
Published: January 2025

Introduction Mental health issues disproportionately affect rural and low-income populations, where access to prevention and treatment is limited. Implementing telemental health services (TMHS) in Federally Qualified Health Centers (FQHCs) could improve accessibility to mental healthcare. This study assessed the effect of TMHS on mental health services utilization in FQHCs, comparing centers with and without TMHS and examined differences in TMHS effect between FQHCs that adopted TMHS before and during the pandemic. Methods The study utilized FQHC-level data from Uniform Data Systems annual performance reports ( N = 9540 FQHC-year) and county-level demographic, health status, and provider characteristic data from 2016 to 2022. A two-way fixed effects model was applied to examine the effect of TMHS on mental health visit rates, supplemented by the Sun and Abraham difference-in-differences estimator. The analysis included both pre-COVID and during-COVID TMHS adopters. Results FQHCs offering TMHS showed 1.04 times increase in overall mental health visit rates compared to those without TMHS. Centers serving higher proportions of Medicaid-insured (1.07 times) and low-income (below 200% FPL; 1.05 times) populations showed even higher visit rates. During-COVID TMHS adopters showed a significant increase (1.05 times), particularly in urban areas, whereas rural adopters did not see significant changes. Conclusion FQHCs offering TMHS showed increased mental health visit rates, especially among low-income and Medicaid-insured populations. FQHCs that adopted TMHS during the pandemic experienced a marked rise in mental health visits, but rural-urban disparities persist, highlighting the ongoing challenges in expanding access to mental healthcare in rural settings.