bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-15 complex-induced IL-10 enhancesPlasmodium-specific CD4+Tfh differentiation and antibody production
Authors: Bravo Morgan , Dileepan Thamotharampillai , Dolan Molly , Hildebrand Jacob , Wolford Jordan , Hamilton Sara E. , Frosch Anne E. , Burrack Kristina S. 
Published: October 2023

ABSTRACTMalaria, which results from infection withPlasmodiumparasites, remains a major public health problem. While humans do not develop long-lived, sterilizing immunity, protection against symptomatic disease develops after repeated exposure toPlasmodiumparasites and correlates with the acquisition of humoral immunity. Despite the established role antibodies play in protection from malaria disease, dysregulated inflammation is thought to contribute to the sub-optimal immune response toPlasmodiuminfection.Plasmodium bergheiANKA (PbA) infection results in a fatal severe malaria disease in mice. We previously demonstrated that treatment of mice with IL-15 complex (IL-15C; IL-15 bound to an IL-15Rα-Fc fusion protein) induces IL-10 expression in NK cells, which protects mice from PbA-induced death. Using a novel MHC class II tetramer to identify PbA-specific CD4+T cells, herein we demonstrate that IL-15C treatment enhances Tfh differentiation. Moreover, genetic deletion of NK cell-derived IL-10 or IL-10R expression on T cells prevents IL-15C-induced Tfh differentiation. Additionally, IL-15C treatment results in increased anti-PbA IgG antibody levels and improves survival following reinfection. Overall, these data demonstrate that IL-15C treatment, via its induction of IL-10 from NK cells, modulates the dysregulated inflammation duringPlasmodiuminfection to promote Tfh differentiation and antibody generation, correlating with improved survival from reinfection. These findings will facilitate improved control of malaria infection and protection from disease by informing therapeutic strategies and vaccine design.
WITHDRAWN: Plasma GPI and PGD are associated with vascular normalization and may serve as novel prognostic biomarkers for lung adenocarcinoma: Multi-omics and multi-dimensional analysis
Authors: Liu Yiran , Wang Yanchi , Mao Liping , Hu Yang , Zhao Rongrong , Zhang Wendi , Xu Huiwen , Xu Buyun , Wu Yutong , Chen Qiong , Tao Xiaobo , Xu Shufan , Zhuang Xun , Lian Yulong , Lu Yihua , Zhang Lei , Tian Tian , Cui Jiahua , Tian Guangyu , Chu Minjie 
Published: October 2023

Withdrawal StatementThe authors have withdrawn their manuscript owing to adjustments have been made to the content. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
A set of circulating microRNAs belonging to the 14q32 chromosomic locus identifies two clinically and phenotypically different subgroups of individuals with recent onset Stage 3 type 1 diabetes
Authors: Sebastiani Guido , Grieco Giuseppina Emanuela , Bruttini Marco , Auddino Stefano , Mori Alessia , Toniolli Mattia , Fignani Daniela , Licata Giada , Nigi Laura , Formichi Caterina , Pugliese Alberto , Evans-Molina Carmella , Overbergh Lut , Tree Timothy , Peakman Mark , Mathieu Chantal , Dotta Francesco 
Published: October 2023

SUMMARYPrevious research has indicated that circulating microRNAs are linked to the onset and progression of type 1 diabetes mellitus (T1DM), making them potential biomarkers for the disease. In this study, we employed a multiplatform sequencing approach to analyze circulating microRNAs in an extended cohort of individuals recently diagnosed with T1DM from the European INNODIA consortium. Our findings revealed that a specific set of microRNAs located within the T1DM susceptibility chromosomal locus 14q32 distinguishes two distinct subgroups of T1DM individuals. To validate our results, we conducted additional analyses on a second cohort of T1DM individuals, independently confirming the identification of these two subgroups, which we have named Cluster A and Cluster B. Remarkably, Cluster B T1DM individuals, who exhibited increased expression of 14q32 miRNAs, displayed a different peripheral blood immunomics profile, possessed a lower T1DM risk HLA genotype, and showed better glycaemic control during follow-up visits compared to Cluster A individuals. Taken together, our findings suggest that this specific set of circulating microRNAs located in the 14q32 locus can effectively identify T1DM subgroups with distinct characteristics and different clinical outcomes during follow-up.GRAPHICAL ABSTRACTHIGHLIGHTSCirculating miRNA profiles in individuals with newly diagnosed Type 1 Diabetes Mellitus (T1DM) can distinguish two subgroups: Cluster A and Cluster B.miR-409-3p, miR-127-3p, and miR-382-5p are increased in the plasma of individuals in Cluster B.Individuals in Cluster B showed lower IAA titers, a reduced prevalence of HLA risk genotype, and an improved glycaemic profile during the follow-up period.Immunomic profiling revealed a reduced frequency of pro-inflammatory immune cells and a higher frequency of exhausted T lymphocytes among individuals in Cluster B.
Perioperative outcomes and platinum resistant recurrence in patients undergoing protocol based total parietal peritonectomy during interval cytoreductive surgery for advanced ovarian cancer- results of the TORPEDO study
Authors: Bhatt Aditi , Sinukumar Snita , Damodaran Dileep , Patel Ankita , Shaikh Sakina , Parikh Loma , Goswami Gaurav , Singh Anjali , Kammar Praveen , Mehta Sanket 
Published: October 2023

AbstractBackground and aimThe TORPEDO (CTRI/2018/12/016789) is the single-arm, prospective, interventional study evaluating the role of a total parietal peritonectomy (TPP) in patients undergoing interval cytoreductive surgery (iCRS). In this manuscript, we report the perioperative outcomes and platinum resistant recurrence (PRR) in 218 patients enrolled in the study.MethodsA TPP was performed in all patients undergoing iCRS irrespective of the residual disease extent. HIPEC was performed as per the clinician’s discretion with 75mg/m2 of Cisplatin. Maintenance therapy was also used at the discretion of the treating clinicians.ResultsFrom 9thDecember 2018 to 31stJuly 2022 (recruitment complete), 218 patients were enrolled at 4 Indian centres. The median surgical PCI was 14 and a complete gross resection was achieved in 95.8%. HIPEC was performed in 130 (59.6%) patients. The 90-day major morbidity was 17.4% and 2.7% patients died within 90 days of surgery. Adjuvant chemotherapy was delayed beyond 6 weeks in 7.3%. At a median follow-up of 19m [95% CI 15-35m], 101 (46.3%) recurrences and 19 (8.7%) deaths had occurred. The median PFS was 22m [95% CI 17-35m] and the median OS not reached. Platinum resistant recurrence was observed in 6.4%. The projected 3-year OS was 81.5% and in 80 patients treated before may 2020, it was 77.5%.ConclusionsThe morbidity and mortality of TPP with or without HIPEC performed during iCRS is acceptable. The incidence was of PRR is low. Early survival results are encouraging and warrant conduction of a randomized controlled trial comparing TPP with conventional surgery.
Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients
Authors: Lötsch Jörn , Gasimli Khayal , Malkusch Sebastian , Hahnefeld Lisa , Angioni Carlo , Schreiber Yannick , Trautmann Sandra , Wedel Saskia , Thomas Dominique , Bouzas Nerea Ferreiros , Brandts Christian , Schnappauf Benjamin , Solbach Christine , Geisslinger Gerd , Sisignano Marco 
Published: October 2023

AbstractBackgroundChemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify the particular types of lipids that are regulated as a consequence of paclitaxel administration and may be associated with the occurrence of post-therapeutic neuropathy.MethodsHigh resolution mass spectrometry lipidomics was applied to quantify d = 255 different lipid mediators in the blood of n = 31 patients drawn before and after paclitaxel therapy for breast cancer treatment. A variety of supervised statistical and machine-learning methods was applied to identify lipids that were regulated during paclitaxel therapy or differed among patients with and without post-therapeutic neuropathy.ResultsTwenty-seven lipids were identified that carried relevant information to train machine learning algorithms to identify, in new cases, whether a blood sample was drawn before or after paclitaxel therapy with a median balanced accuracy of up to 90%. One of the top hits, sphinganine-1-phosphate (SA1P), was found to induce calcium transients in sensory neurons via the transient receptor potential vanilloid 1 (TRPV1) channel and sphingosine-1-phosphate receptors.SA1P also showed different blood concentrations between patients with and without neuropathy.ConclusionsPresent findings suggest a role for sphinganine-1-phosphate in paclitaxel-induced biological changes associated with neuropathic side effects. The identified SA1P, through its receptors, may provide a potential drug target for co-therapy with paclitaxel to reduce one of its major and therapy-limiting side effects.
PowerAI-CVD – the first Chinese-specific, validated artificial intelligence-poweredin-silicopredictive model for cardiovascular disease
Authors: Li Lifang , Chou Oscar Hou In , Lu Lei , Pui Hugo Hok Him , Lee Quinncy , Kaur Narinder , Wong Wing Tak , Chang Carlin , Liu Haipeng , Wai Abraham Ka Chung , Cheung Bernard Man Yung , Liu Tong , Tse Gary , Zhou Jiandong 
Published: October 2023

AbstractBackgroundThe main risk stratification tools for identifying high-risk individuals of cardiovascular disease (CVD) are based on Western populations. Few models are developed specifically for Asian populations and are not enhanced by artificial intelligence (AI). The aim of this study is to develop the first AI-powered quantitative predictive tool for CVD (PowerAI-CVD) incorporate physiological blood pressure measurements, existing diseases and medications, and laboratory tests from Chinese patients.MethodsThe study analysed patients who attended family medicine clinics between 1stJanuary 2000 and 31stDecember 2003. The primary outcome was major adverse cardiovascular events (MACE) defined as a composite of myocardial infarction, heart failure, transient ischaemic attack (TIA)/stroke or cardiovascular mortality, with follow-up until 31stDecember 2019. The performance of AI-driven models (CatBoost, XGBoost, Gradient Boosting, Multilayer Perceptron, Random Forest, Naïve Bayes, Decision Tree, k-Nearest Neighbor, AdaBoost, SVM-Sigmod) for predicting MACE was compared. Predicted probability (ranging between 0 and 1) of the best model (CatBoost) was used as the baselinein-silicomarker to predict future MACE events during follow-up.ResultsA total of 154,569 patients were included. Over a median follow-up of 16.1 (11.6-17.8) years, 31,061 (20.44%) suffered from MACE (annualised risk: 1.28%). The machine learningin-silicomarker captured MACE risk from established risk variables (sex, age, mean systolic and diastolic blood pressure, existing cardiovascular diseases, medications (anticoagulants, antiplatelets, antihypertensive drugs, and statins) and laboratory tests (NLR, creatinine, ALP, AST, ALT, HbA1c, fasting glucose, triglyceride, LDL and HDL)). MACE incidences increased quantitatively with ascending quartiles of thein-silicomarker. The CatBoost model showed the best performance with an area under the receiver operating characteristic curve of 0.869. The CatBoost model basedin-silicomarker shows significant prediction strength for future MACE events, across subgroups (age, sex, prior MACE, etc) and different follow-up durations.ConclusionsThe AI-powered risk prediction tool can accurately forecast incident CVD events, allowing personalised risk prediction at the individual level. A dashboard for predictive analytics was developed, allowing real-time dynamic updates of risk estimates from new data. It can be easily incorporated into routine clinical use to aid clinicians and healthcare administrators to identify high-risk patients.Graphical Abstract
Downstream characteristics of extended flat plate trailing edge on S809 wind turbine blade under various turbulent intensities
Authors: S. Mano , S. Nadaraja Pillai 
Published: October 2023

Purpose
This study aims to investigate the effect of downstream characteristics of S809 wind turbine blade with various extended flat plate (EFP) configuration. Wind farms are recently modified to improve the power production through placing number of wind turbines and locations.

Design/methodology/approach
A series of wind tunnel experiments were carried out to evaluate the downstream wake characteristics of the S809 airfoil attached with various EFP (EFP, A = 0.1C, 0.2C and 0.3C) at various angles of attack corresponding to free stream velocity Reynolds number (Re) = 2.11 × 105 and various turbulence intensity (TI = 5%, 7%, 10% and 12%).

Findings
For the S809 wind turbine blade attached with EFP, the downstream velocity ratio decreases with increasing in angle of attack and the velocity deficit decrease with increasing turbulence intensity (TI) up to TI = 10%. The wake intensity for the S809 wind turbine blade and S809 airfoil with 10% of chord EFP performs the same for each downstream location.

Practical implications
Placing the wind turbine in the wind park next to another wind turbine poses a potential challenge for the park power performance. This research addresses the characteristics of the downstream turbulence intensity profile modified with the EFP in the wind turbine blade which improves the downstream characteristics of the turbine in the wind park.

Originality/value
The downstream velocity ratio decreases with increasing angle of attack and the velocity deficit decrease with increasing turbulence intensity (TI) up to TI = 10%.
Clinical utility of a cytomegalovirus‐specific T cell assay in assessing the risk of post‐prophylaxis cytomegalovirus infection and post‐treatment relapse
Authors: Dioverti Maria Veronica , Bhaimia Eric , Yetmar Zachary A. , Melendez Dante P. , Misner Lori , Beito Elaine , Deziel Paul J. , Theel Elitza S. , Razonable Raymund R. 
Published: October 2023

AbstractIntroductionCytomegalovirus (CMV) causes significant morbidity in solid organ transplant recipients (SOTR). Measuring cell‐mediated immunity (CMI) may inform the risk of CMV infection after antiviral prophylaxis and predict relapse after CMV treatment.MethodsWe serially assessed CMV CMI using the QuantiFERON‐CMV assay (QF‐CMV; Qiagen, Germantown, MD) in two cohorts of SOTRs: during valganciclovir prophylaxis and during treatment of CMV viremia. Results of CMI were correlated with post‐prophylaxis CMV infection and post‐treatment relapse, respectively.ResultsOnly one (4.2%) of 24 CMV D+/R‐ patients demonstrated positive QF‐CMV by the end of valganciclovir prophylaxis. Four (16.6%) patients developed post‐prophylaxis CMV infection; all four had undetectable QF‐CMV at end of prophylaxis. Among 20 patients treated for CMV infection, 18 (90%) developed QF‐CMV levels >.2 IU/mL by end of antiviral treatment and none developed CMV relapse. In contrast, the single patient who relapsed after completing treatment had a CMV CMI <.2 IU/ml (p = .0036).ConclusionSince CMV D+/R‐ SOTRs are unlikely to develop adequate CMV CMI while receiving valganciclovir prophylaxis, the utility of CMV CMI monitoring for risk stratification during time of prophylaxis had limited value. Conversely, CMV CMI testing may be a useful marker of the risk of CMV relapse after antiviral treatment.
Potassium‐lowering effects of sodium zirconium cyclosilicate in the early post‐transplant period
Authors: Shockey William , Wiegel Joshua J. , Parajuli Sandesh , Garg Neetika , Swanson Kurtis J. , Mandelbrot Didier A. 
Published: October 2023

AbstractProblemHyperkalemia is a serious condition among intra‐abdominal transplant recipients, and the safety and efficacy of sodium zirconium cyclosilicate (SZC) for its management during the early post‐transplant period are not well‐established.MethodsAdults who received at least one 10‐g dose of SZC within 14 days after an intra‐abdominal transplant between January 2020 and July 2022 were included in our study. The primary outcome was the change in potassium (K+) levels following the first SZC dose. Other analyses explored adjunctive potassium‐lowering therapies, potential gastrointestinal complications, and patient subgroups based on therapy and transplant type.ResultsAmong the recipients (n = 46), 11 were kidney recipients, 26 were liver recipients, seven were simultaneous liver/kidney recipients, and two were simultaneous pancreas/kidney recipients. The mean time to first dose post‐transplant was 7.6 (±4) days, and the mean change in serum K+ after the initial SZC dose was −.27 mEq (p = .001). No gastrointestinal complications were observed following the SZC dose. The mean increase in serum bicarbonate was .58 mEq (p = .41) following the first dose of SZC. Four kidney recipients required dialysis following the SZC dose.ConclusionThis study represents the largest investigation on the use of SZC in transplant recipients. A single 10‐g dose of SZC reduced serum K+ levels in all subgroups, while the use of adjunctive K+‐lowering therapies did not provide additional reduction beyond the effects of SZC. Importantly, no gastrointestinal complications were observed. These findings suggest that SZC may be a safe and promising therapeutic option for hyperkalemia management following solid organ transplantation.
Successful prenatal treatment with continuous chronic maternal hyperoxygenation therapy in hypoplastic left heart in two pregnancies: Case report
Authors: Bolluk Gokhan , Oztarhan Aylin , Vural Cagdas , Oztarhan Kazim , Gedikbasi Ali 
Published: October 2023

AbstractMaternal hyperoxygenation (MH) has been studied as a diagnostic tool to evaluate pulmonary vasculature and as a treatment option to improve the growth of fetal left heart in fetuses with left‐sided cardiac defects. Chronic maternal hyperoxygenation (CMH) therapy leads to an improvement in fetal pulmonary blood flow resulting in an enhanced venous return to the left heart with increased gestational age. With this manipulation it is anticipated to augment blood flow directed remodeling of the left heart structures and to improve left heart growth spanning from the mitral valve to the aortic isthmus. However, there are concerns about CMH therapy with regard to fetal complications with growth restriction and fetal brain development. Now, with two successful cases we try to discuss this fetal treatment option and related concerns.
The unintended energy efficiency gain from tax incentives for investment: Micro‐evidence from quasi‐natural experiments in China
Authors: Song Yijia , Li Xitao , Liu Ruoxi , Peng Xin 
Published: October 2023

AbstractIn light of the economic recession in the post‐pandemic era, countries have implemented a wide array of fiscal stimulus measures as a means of addressing the prevailing economic challenges but often neglect to consider the consequences of these stimuli on the environment. Therefore, it is crucial for the government to take environmental considerations into economic stimulus packages, aiming to achieve a sustainable “green recovery.” Using China's value‐added tax (VAT) reform as a quasi‐natural experiment, we find that VAT incentives have significantly improved the firm's energy efficiency through factor substitution and technological progress, indicating that tax incentives are beneficial to economic stimulus and energy saving. In addition, we find that energy market distortions play a significant negative moderating role, which weakens energy efficiency gained from the VAT incentives. Furthermore, heterogeneity analysis shows that the improvement of energy efficiency is concentrated in non‐state, high‐capital intensity, and high financing‐dependent firms. According to our findings, policymakers should have a thorough understanding of the potential of tax incentives for investment as a policy tool for achieving a “green recovery” as long as the energy market is efficient.
Hummocky sedimentary structures within rippled beds due to combined orbital waves and transverse currents
Authors: Wu Xuxu , Carling Paul A. , Parsons Daniel 
Published: October 2023

AbstractHummocky cross‐stratification is commonly observed in the marine offshore transition to lower shoreface environments. However, to date, the origins of hummocky cross‐stratification and its associated hummocky bedforms and hydrodynamic processes remain controversial and enigmatic. In the present study, a large‐scale flume experiment was conducted to study the formation of hummocky bedforms. In the central test area of the flume, combined flow with water waves, with period of 2 s and velocity of 0.34 m s−1, progressed at a right angle to a current with velocity of 0.17 m s−1, whereas a wave‐alone condition pertained upstream and downstream of the test area. The combined‐flow ripples in the test area had smaller dimensions than wave ripples, but their cross‐section geometries were very similar. Most importantly, the experimental results, for the first time, revealed that humps occur with lengths up to approximately 40 mm beneath combined flow ripples. The formation of these structures appears to relate to the enhanced turbulence for the combined flow, because the turbulence kinetic energy for combined flow was ca 50% higher than that under the wave‐only condition. Moreover, the observed small‐scale humps in the present experiment had comparable cross‐section geometries with hummock‐like bedforms previously reported in laboratories and fields under storm conditions. Additionally, these humps could scale up to large‐size hummocks under waves with longer period and faster velocity than the present conditions. The present experiment indicates that waves perpendicular to a current do generate hummock‐like structures in association with ripples and therefore provide a new perspective for future study of the origins of hummocky cross‐stratification.
Interface Characterization of Hybrid M21 Composites Through DCB and ENF Experiments and Numerical Predictions
Authors: Seamone Andrew A. , Lin Shiyao , Waas Anthony M. , Ranatunga Vipul P. 
Published: October 2023

Abstract
The technological advancement of carbon fiber reinforced polymers (CFRPs) has enabled innovative and complex use of the composites in the aerospace industry. Due to the time and cost of performing numerous physical experiments, finite element (FE) modeling tools for CFRP damage evolution and characterization are necessary. Interlaminar delamination is a structurally significant damage event in composites. This study investigates DCB and ENF experiments to characterize the fracture toughness of hybrid M21 CFRPs containing both unidirectional tape and woven lamina. The results of this study are combined with previous studies to define the interface properties of tape-tape interfaces, weave-weave interfaces, and hybrid interfaces with varying ply angle orientations. The experiments are recreated using cohesive modeling within a finite element framework to numerically characterize the cohesive strength and fracture toughness for each interface combination. This information lays the groundwork for future numerical predictions of structural configurations manufactured using M21 hybrid composites.