bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteolytic remodeling of 3D bioprinted tumor microenvironments
Authors: Rasti Boroojeni Fatemeh , Naeimipour Sajjad , Lifwergren Philip , Abrahamsson Annelie , Dabrosin Charlotta , Selegård Robert , Aili Daniel 
Published: December 2023

Abstract
In native tissue, remodeling of the pericellular space is essential for cellular activities and is mediated by tightly regulated proteases. Protease activity is dysregulated in many diseases, including many forms of cancer. Increased proteolytic activity is directly linked to tumor invasion into stroma, metastasis, and angiogenesis as well as all other hallmarks of cancer. Here we show a strategy for 3D bioprinting of breast cancer models using well-defined protease degradable hydrogels that can facilitate exploration of the multifaceted roles of proteolytic extracellular matrix remodeling in tumor progression. We designed a set of bicyclo[6.1.0]nonyne functionalized hyaluronan (HA)-based bioinks cross-linked by azide-modified poly(ethylene glycol) (PEG) or matrix metalloproteinase (MMP) degradable azide-functionalized peptides. Bioprinted structures combining PEG and peptide-based hydrogels were proteolytically degraded with spatial selectivity, leaving non-degradable features intact. Bioprinting of tumor-mimicking microenvironments using bioinks comprising human breast cancer cells (MCF-7) and fibroblast in hydrogels with different susceptibilities to proteolytic degradation shows that MCF-7 proliferation and spheroid size were significantly increased in protease degradable hydrogel compartments, but only in the presence of fibroblasts. In the absence of fibroblasts in the stromal compartment, cancer cell proliferation was reduced and did not differ between degradable and nondegradable hydrogels. The interactions between spatially separated fibroblasts and MCF-7 cells consequently resulted in protease-mediated remodeling of the bioprinted structures and a significant increase in cancer cell spheroid size, highlighting the close interplay between cancer cells and stromal cells in the tumor microenvironment and the influence of proteases in tumor progression.
Preparation and application of low temperature protection materials by Na2SO4·10H2O/PS phase change microcapsules
Authors: Xie Wenhan , Jiang Yongqing , Liu Zhengmei , Wang Bo , Han Tianchan 
Published: December 2023

Abstract
To find the phase change microcapsule material (MEPCM) with suitable temperature and high heat storage energy. The phase change microcapsules with sodium sulfate decahydrate (Na2SO4·10H2O) as core material and polystyrene (PS) as wall material were prepared by emulsion polymerization. The microcapsule is fixed on the cloth of the overalls by coating method, and the thermoregulation fabric is obtained. The microcapsules were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and infrared spectroscopy (FTIR). Fabrics are tested for durability, air permeability and temperature control. The DSC results show that the Tc and Tm of Na2SO4·10H2O/PS microcapsules are 26.0 °C and 58.0 °C, respectively, and the ΔHc and ΔHm are 64.0 J g−1 and 121.1 J g−1, respectively. The TG results show that the first weight loss temperature range is 104.1 ∼136.7 °C, and the second weight loss temperature range is 395.5 ∼434.6 °C. The infrared spectral characteristic peaks of microcapsules include all the characteristic peaks of Na2SO4·10H2O and PS. In the range of microcapsule phase transition temperature, the cloth treated with 0.5 g MEPCM and 1.5 g MEPCM delayed the temperature change by 16.0 ∼23.0 °C and 10.0 ∼18.0 °C, respectively, compared with the blank cloth. The fabric treated with 0.5 g microcapsules was subjected to 100 and 300 heating/cooling cycles. Compared with before and after the cycles, the fabric after thermal shock cycles showed a 4.15% and 3.56% reduction in delayed temperature changes rate in a rising and falling temperature environment. Therefore, Na2SO4·10H2O/PS microcapsule material can achieve the goal of heat storage and energy storage, and can be used as a low-temperature operation protection material.
Effects of thickness and roughness on plasmonic characteristics of gold thin films deposited on polished optical fiber
Authors: Sukma Freygieon Ogiek Rizal , Hanif Mahardika Auditia , Masruroh  , Santjojo Dionysius J D H , Apsari Retna , Susanto Hendra , Tazi Imam 
Published: December 2023

Abstract
The thickness and roughness of metal layers substantially affect the performance of surface plasmon resonance (SPR)-based sensors. The deposition methods, control parameters, and substrate characteristics influence the layer thickness and roughness. This study investigates the SPR characteristics of a polished optical fiber surface coated with gold (Au) metal of different thicknesses. The Au layer is deposited via the thermal evaporation method, and its thickness is varied by controlling the deposition time (3–6 min). A proportionality relationship between thickness and deposition time is observed. Island-shaped structures in gold (Au) morphology are formed due to low adhesion to the substrate. The shape of this island creates gaps in the layer, causing scattering. In addition, the roughness on the gold surface triggers the Localized Surface Plasmon Resonance (LSPR) phenomenon. As a result, the measured dielectric characteristics differ from the reference. The SPR curve calculation simulation was carried out based on reference optical parameters and measurement results by an ellipsometer, which were then compared with experiments. The obtained results show that the substrate roughness, morphology, and thickness of the Au layer play an essential role in determining the characteristics of the SPR curve in a fiber optic plasmonic sensor. As a result, in basic experiments, the sample with an Au thickness of 27.37 nm (deposition time = 3 min) shows better characteristics (half-maximum full width, minimum transmittance, and resonance wavelength) compared with the sample with an Au thickness of 53.97 nm (deposition time = 4 min), Although 53.97 nm is the optimal thickness from the simulation using reference optical parameters (smooth substrate surface and smooth gold layer).
Variational quantum algorithms for simulation of Lindblad dynamics
Authors: Watad Tasneem M , Lindner Netanel H 
Published: December 2023

Abstract
We introduce variational hybrid classical-quantum algorithms to simulate the Lindblad master equation and its adjoint for time-evolving Markovian open quantum systems and quantum observables. Our methods are based on a direct representation of density matrices and quantum observables as quantum superstates. We design and optimize low-depth variational quantum circuits that efficiently capture the unitary and non-unitary dynamics of the solutions. We benchmark and test the algorithms on different models and system sizes, showing their potential for utility with near-future hardware.
On some recent Fitchian arguments
Authors: Small Julian D 
Published: December 2023

Abstract
Both Jago, in his 2020 article ‘A short argument for truthmaker maximalism’ and his 2021 article ‘Which Fitch?’, and Loss in his 2021 article ‘There are no fundamental facts’, employ arguments similar to that familiar from the Church–Fitch Paradox to infer some substantial metaphysical claims from their mere logical possibility. Trueman in his 2022 article ‘Truthmaking, grounding and Fitch’s paradox’ and Nyseth in his 2022 article ‘Fitch’s paradox and truthmaking’ respond by using exactly the same kind of argument to prove contrary theses. Intended as bad company objections, these counterarguments cast doubt on the original arguments, but do not actually identify their flaw. This paper aims to fill this gap.
Contested, Discounted and Disproven Stories of Rape: The Social Pathways of Rape Reporting
Authors: Laugerud Solveig , Skilbrei May-Len 
Published: December 2023

Abstract
Tensions between societal and legal norms regarding rape shape people’s perceptions of the law and the use of various legal strategies. This article investigates what happens when a claim of rape is discredited, resulting in the claimant, instead, being prosecuted for presenting a false accusation. Based on the analysis of verdicts in cases of false accusations of rape, we identify four pathways into the criminal justice process for such cases and three turning points whereby an accusation of rape is contested by the police and instead prosecuted as a false accusation. We conclude that this seems to follow from the strength of the ideal that victims of rape are listened to and encouraged to come forward with their claims.
How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide
Authors: Thomas Kim S , Howells Laura , Leshem Yael A , Simpson Eric L , Apfelbacher Christian , Spuls Phyllis I , Gerbens Louise A A , Jacobson Michael E , Katoh Norito , Williams Hywel C , Stuart Beth L 
Published: December 2023

Abstract

Background
The Harmonising Outcome Measures for Eczema (HOME) initiative has agreed upon the Core Outcome Set (COS) for use in atopic dermatitis (AD) clinical trials, but additional guidance is needed to maximize its uptake.

Objectives
To provide answers to some of the commonly asked questions about using the HOME COS; to provide data to help with the interpretation of trial results; and to support sample size calculations for future trials.

Methods and results
We provide practical guidance on the use of the HOME COS for investigators planning clinical trials in patients with AD. It answers some of the common questions about using the HOME COS, how to access the outcome measurement instruments, what training/resources are needed to use them appropriately and clarifies when the COS is applicable. We also provide exemplar data to inform sample size calculations for eczema trials and encourage standardized data collection and reporting of the COS.

Conclusions
By encouraging adoption of the COS and facilitating consistent reporting of outcome data, it is hoped that the results of eczema trials will be more comprehensive and readily combined in meta-analyses and that patient care will subsequently be improved.
Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt–mTOR axis in intrahepatic cholangiocarcinoma
Authors: Hori Yutaro , Yoh Tomoaki , Nishino Hiroto , Okura Keisuke , Kurimoto Makoto , Takamatsu Yuichi , Satoh Motohiko , Nishio Takahiro , Koyama Yukinori , Ishii Takamichi , Iwaisako Keiko , Seo Satoru , Hatano Etsuro 
Published: December 2023

Abstract
The role of the ferroptosis-related gene glutathione peroxidase 4 (GPX4) in oncology has been extensively investigated. However, the clinical implications of GPX4 in patients with intrahepatic cholangiocarcinoma (ICC) remain unknown. This study aimed to evaluate the prognostic impact of GPX4 and its underlying molecular mechanisms in patients with ICC. Fifty-seven patients who underwent surgical resection for ICC between 2010 and 2017 were retrospectively analyzed. Based on the immunohistochemistry, patients were divided into GPX4 high (n = 15) and low (n = 42) groups, and clinical outcomes were assessed. Furthermore, the roles of GPX4 in cell proliferation, migration and gene expression were analyzed in ICC cell lines in vitro and in vivo. The results from clinical study showed that GPX4 high group showed significant associations with high SUVmax on 18F-fluorodeoxyglucose-positron emission tomography (≥8.0, P = 0.017), multiple tumors (P = 0.004), and showed glucose transporter 1 (GLUT1) high expression with a trend toward significance (P = 0.053). Overall and recurrence-free survival in the GPX4 high expression group were significantly worse than those in the GPX4 low expression group (P = 0.038 and P &lt; 0.001, respectively). In the experimental study, inhibition of GPX4 attenuated cell proliferation and migration in ICC cell lines. Inhibition of GPX4 also decreased the expression of glucose metabolism-related genes, such as GLUT1 or HIF1α. Mechanistically, these molecular changes are regulated in Akt–mechanistic targets of rapamycin axis. In conclusion, this study suggested the pivotal value of GPX4 serving as a prognostic marker for patients with ICC. Furthermore, GPX4 can mediate glucose metabolism of ICC.
The psychological, social, and quality of life outcomes of people with a cardiac implantable electronic device: an umbrella review
Authors: Nicmanis Mitchell , Chur-Hansen Anna , Oxlad Melissa 
Published: December 2023

Abstract

Aims
To synthesize the psychological, social, and quality of life outcomes of people with a cardiac implantable electronic device.

Methods and results
An umbrella review of systematic reviews that reported the psychological, social, or quality of life outcomes of adults with a cardiac implantable electronic device was conducted. This umbrella review was pre-registered with PROSPERO (CRD42023437078) and adhered to JBI and PRISMA guidelines. Seven databases (CINAHL, Cochrane Library, Embase, EmCare, PsycINFO, PubMed, and the Web of Science) were searched alongside citation and bibliographic searches. Methodological quality was assessed using the JBI Checklist of Systematic Reviews and Research Syntheses. Due to the heterogeneity of the included reviews, the findings were reported narratively. A total of 14 systematic reviews met the inclusion criteria; 11 considered quality of life outcomes, and 3 considered psychological outcomes. Little difference in quality of life was found between people with an implantable cardioverter-defibrillator and controls; however, a high prevalence of psychological disorders was present. Cardiac resynchronization therapy devices demonstrated improvements in quality of life compared with control groups, alongside possible cognitive benefits. Quality of life did not differ between subcutaneous and transvenous implantable cardioverter-defibrillators. Pacemakers were associated with improved post-implantation quality of life.

Conclusion
Research on the psychosocial and quality of life outcomes of people with a cardiac implantable electronic device is limited and inconsistent. Given the heterogeneity of the current research, conclusions are uncertain. Nevertheless, some recipients may experience adverse psychosocial complications. Further research employing rigorous methodologies is needed, and healthcare practitioners should provide care that acknowledges the potential for adverse psychosocial experiences.

Registration
PROSPERO: CRD42023437078
Experimental evolution under varying sex ratio and behavioral plasticity in response to perceived competitive environment independently affect calling effort in male crickets
Authors: McKermitt Jack T , Foquet Bert , Kuna Will , Hunt John , Sadd Ben M , Sakaluk Scott K 
Published: December 2023

Abstract
The operational sex ratio (OSR) is a key component influencing the magnitude of sexual selection driving the evolution of male sexual traits, but males often also retain the ability to plastically modulate trait expression depending on the current environment. Here we employed an experimental evolution approach to determine whether the OSR affects the evolution of male calling effort in decorated crickets, a costly sexual trait, and whether plasticity in calling effort is altered by the OSR under which males have evolved. Calling effort of males from 2 selection regimes maintained at different OSRs over 18–20 generations (male vs. female biased) was recorded at 2 different levels of perceived competition, in the absence of rivals or in the presence of an experimentally muted competitor. The effect of the OSR on the evolution of male calling effort was modest, and in the opposite direction predicted by theory. Instead, the immediate competitive environment strongly influenced male calling effort as males called more in the presence of a rival, revealing considerable plasticity in this trait. This increased calling effort came at a cost, however, as males confined with a muted rival experienced significantly higher mortality.
Gut diazotrophs in lagomorphs are associated with season but not altitude and host phylogeny
Authors: Wang Sijie , Su Ming , Hu Xueqian , Wang Xiaochen , Han Qian , Yu Qiaoling , Heděnec Petr , Li Huan 
Published: December 2023

AbstractInvertebrates such as termites feeding on nutrient-poor substrate receive essential nitrogen by biological nitrogen fixation of gut diazotrophs. However, the diversity and composition of gut diazotrophs of vertebrates such as Plateau pikas living in nutrient-poor Qinghai–Tibet Plateau remain unknown. To fill this knowledge gap, we studied gut diazotrophs of Plateau pikas (Ochotona curzoniae) and its related species, Daurian pikas (Ochotona daurica), Hares (Lepus europaeus) and Rabbits (Oryctolagus cuniculus) by high-throughput amplicon sequencing methods. We analyzed whether the gut diazotrophs of Plateau pikas are affected by season, altitude, and species, and explored the relationship between gut diazotrophs and whole gut microbiomes. Our study showed that Firmicutes, Spirochaetes, and Euryarchaeota were the dominant gut diazotrophs of Plateau pikas. The beta diversity of gut diazotrophs of Plateau pikas was significantly different from the other three lagomorphs, but the alpha diversity did not show a significant difference among the four lagomorphs. The gut diazotrophs of Plateau pikas were the most similarly to that of Rabbits, followed by Daurian pikas and Hares, which was inconsistent with gut microbiomes or animal phylogeny. The dominant gut diazotrophs of the four lagomorphs may reflect their living environment and dietary habits. Season significantly affected the alpha diversity and abundance of dominant gut diazotrophs. Altitude had no significant effect on the gut diazotrophs of Plateau pikas. In addition, the congruence between gut microbiomes and gut diazotrophs was low. Our results proved that the gut of Plateau pikas was rich in gut diazotrophs, which is of great significance for the study of ecology and evolution of lagomorphs.
Corpse identification in mass disasters and other violence: the ethical challenges of a humanitarian approach
Authors: Vaswani Vina , Caenazzo Luciana , Congram Derek 
Published: December 2023

Abstract
In October 2022, the Centre for Ethics of Yenepoya University hosted a national workshop entitled: “Respect for human dignity of the unidentified dead from mass disasters and other violence: strategies for the ethical management of biological samples and personal data”. The aim was to explore and share experience and ethical considerations regarding the management and identification of human remains in the event of disasters, with the purpose to arrive at a general consensus about what constitutes the ethical foundation of the management of unidentified human remains in forensic practice and, in particular, contextualizing this in India. The main ethical consideration that emerged was tracing the missing and identifying the dead are crucial to maintaining or restoring basic human rights and responsible relief activities. Identification is not only an organizational and scientific achievement but, regardless of circumstances, also necessarily and always an activity with significant political, epistemic, and philosophical relevance and consequence. In India, it could be important to consider new legal provisions for the management of human samples so that this would provide a starting point for the treatment of human remains managed for forensic purposes with uniformity in the country. Another important step in which governments should take part regards the involvement and education of the general public to develop their interest in this important goal. In the field of forensic anthropology, artificial intelligence can support, through the use of algorithms, the decision-making process that leads to the identification of the victim or its remains. Furthermore, they can be used to extract new knowledge from huge databases and shorten identification through computer automation of data binding activities. Applying artificial intelligence tools in forensic sciences to collect new information from massive datasets to enhance knowledge, and reduce human subjectivity and errors, provides a greater scientific basis that could improve the strength of the evidence and support the admissibility of expert evidence. In light of the general lack of national/international guidance about ethical oversight for identification and care of human remains, the fact that regulations are frequently not adequate to govern ethical aspects, we hope that an internationally recognized body should develop such guidance in collaboration with relevant organizations.
EARLY LIFE COGNITION, EDUCATION, AND DEMENTIA RISK
Authors: Herd Pamela , Williams Victoria , Sicinski Kamil 
Published: December 2023

Abstract
Educational attainment is one of the strongest predictors of Alzheimer’s and Related Dementias (ADRD). Yet, much remains unknown as to how early life factors, particularly early life cognitive function, and early life environments, such as family environments, help explain why education so robustly protects against later life dementia. Is the influence of educational attainment not so much the additional schooling, but rather antecedent factors, like early life cognition and family environments that both build cognitive reserve and predict subsequent educational attainment? In short, is education merely a proxy for these antecedent influences? Consequently, we use the Wisconsin Longitudinal Study, which includes 80 years of prospectively collected data on a sample of 1 in every 3 high school graduates, and a selected sibling, from the class of 1957. Sibling models, and the inclusion of prospectively collected early life cognitive function and educational histories, allows us to explore the role of these early life conditions and the role they play in shaping the relationship between education and ADRD. We find a robust independent influence of education on ADRD risk, early life family environments had little impact on the relationship. Adolescent cognition, however, which we show is influenced by family environments, does partly explain why educational attainment influences later life ADRD risk, though both adolescent IQ and education independently influence the risk for and resilience against dementia.
BUILDING THE COLLABORATIVE COMMUNITY-ACADEMIC TEAM, DESIGNING OBJECTIVES, AND GETTING FUNDED
Authors: Baker Zachary , Fairbanks Sheryl , Wolfe Warren , Frazier Robbin , Millenbah Ashley 
Published: December 2023

Abstract
Having attended the Former Dementia Caregiver Re-Entry Initiative since 2019, its benefits were readily apparent but two limitations were identified: 1) two facilitators (i.e., Wolfe and Fairbanks) cannot serve the millions of Bereaved Dementia Caregivers in the US alone and 2) members have primarily been non-Hispanic White. These realizations inspired efforts to bring the group to more Bereaved Dementia Caregivers. The present community-created model of helping Bereaved Dementia Caregivers deserved community-integrated leadership if that model was to be effectively adapted and disseminated. Our team’s ambition is to bring the group to racially and ethnically minoritized Bereaved Dementia Caregivers, broadly. However, we felt that we could most effectively do this in stages. Rather than trying to figure out how to make the model fit for all people, we homed in on African Americans, with whom we had many local ties. We also took a step back (at the behest of Ms. Frazier) to not only ask about how to adapt the model for a need we assumed existed, but also to explore the strengths of African American communities and ask if unmet needs existed. This model had the benefits of intellectual humility, respect for the persons we were working with, and strengthened the value of our funded research (i.e., even if we found there weren’t unmet needs, we would be able to learn of strengths that we might be able to share with other communities who do have unmet needs).