bluuebunny/crossref_metadata_2025_split huggingface dataset:
S100B vs. “GFAP and UCH-L1” assays in the management of mTBI patients
Authors: Oris Charlotte , Bouillon-Minois Jean-Baptiste , Kahouadji Samy , Pereira Bruno , Dhaiby Gabriel , Defrance Valentin Bailly , Durif Julie , Schmidt Jeannot , Moustafa Farès , Bouvier Damien , Sapin Vincent 
Published: November 2023

Abstract

Objectives
To compare for the first time the performance of “GFAP and UCH-L1” vs. S100B in a cohort of patients managed for mild traumatic brain injury (mTBI) according to actualized French guidelines.

Methods
A prospective study was recently carried at the Emergency Department of Clermont-Ferrand University Hospital in France. Patients with mTBI presenting a medium risk of complications were enrolled. Blood S100B and “GFAP and UCHL-1” were sampled and measured according to French guidelines. S100B was measured in patients with samples within 3 h of trauma (Cobas®, Roche Diagnostics), while GFAP and UCHL-1 were measured in all patients (samples <3 h and 3–12 h) using another automated assay (i-STAT® Alinity, Abbott).

Results
For sampling <3 h, serum S100B correctly identifies intracranial lesions with a specificity of 25.7 % (95 % CI; 19.5–32.6 %), a sensitivity of 100 % (95 % CI; 66.4–100 %), and a negative predictive value of 100 % (95 % CI; 92.5–100 %). For sampling <12 h, plasma “GFAP and UCH-L1” levels correctly identify intracranial lesions with a specificity of 31.7 % (95 % CI; 25.7–38.2 %), a sensitivity of 100 % (95 % CI; 73.5–100 %), and a negative predictive value of 100 % (95 % CI; 95–100 %). Comparison of specificities (25.7 vs. 31.7 %) did not reveal a statistically significant difference (p=0.16).

Conclusions
We highlight the usefulness of measuring plasma “GFAP and UCH-L1” levels to target mTBI patients (sampling within 12 h post-injury) and optimize the reduction of CT scans.
Kelsenian Courts in an Ethnic Key: A Nightmare or a Noble Dream?
Authors: Kulenović Nedim 
Published: November 2023

Abstract
It is recognized that constitutionalism in divided societies is often strained and may require appropriate tailoring, but how far should that go? Constitutional courts – traditionally conceived as independent and impartial guardians of the constitutional order and the rule of law – seem to defeat the point of consensual decision-making settlement promised by consociational power-sharing solutions frequently recommended for deeply divided societies. One way of cutting this Gordian knot is by offering a hybrid solution, a sort of consociationalised constitutional court. The legitimacy of such an institution, in the context of a consociational political regime, is to be secured by it itself becoming a ‘power-sharing court’, strongly reflecting the salient cleavages dividing the society, and incorporating power-sharing elements in its structure and decision-making rules. In deeply divided societies where such cleavages are ethnic ones, and they often are, the constitutional court would be an ethnic court. This chapter critically examines such a model, by focusing on three such courts in Bosnia and Herzegovina, in particular the Bosnian Constitutional Court, often seen as an example of a ‘strong power-sharing court’. In particular, it considers the extent to which the standard model of the constitutional court can be bent out of shape, while retaining its original functions.
Memes to an End: Why Internet Memes Matter to Information Research
Authors: Tulloch Bonnie J. 
Published: November 2023

Abstract
This theoretical paper explores the significance of Internet memes to the field of information research. Adopting a constructivist framework, it conceptualizes memes as documents that undermine popular assumptions about people’s engagements with information. In particular, it argues that Internet memes are conceptual tools through which people can negotiate different representations of reality and the logics that underlie them. Through a close reading of several memetic examples, I propose that memes are a means through which Internet users document and test their values against those of others, thereby allowing them to explore the different courses of action associated with situations they encounter. Memetic communication is thus presented as an important new information literacy practice that has critical implications for the following research areas: education, freedom of expression, ethics and policy, and the preservation of cultural heritage.
METTL16 in human diseases: What should we do next?
Authors: Zhang Hui , Yin Mengqi , Huang Hua , Zhao Gongfang , Lu Mingliang 
Published: November 2023

Abstract
METTL16 is a class-I methyltransferase that is responsible for depositing a vertebrate-conserved S-adenosylmethionine site. Since 2017, there has been a growing body of research focused on METTL16, particularly in the field of structural studies. However, the role of METTL16 in cell biogenesis and human diseases has not been extensively studied, with limited understanding of its function in disease pathology. Recent studies have highlighted the complex and sometimes contradictory role that METTL16 plays in various diseases. In this work, we aim to provide a comprehensive summary of the current research on METTL16 in human diseases.
Order of first-play in simulated versus monetary gambling
Authors: Russell Alex M. T. , Hing Nerilee , Newall Philip , Greer Nancy , Dittman Cassandra K. , Thorne Hannah , Rockloff Matthew 
Published: November 2023

AbstractBackground and aimsSimulated gambling products, like loot boxes and social casino games, contain gambling elements, but are not classified as gambling. They are available to minors, raising concerns about a “gateway effect” into gambling. This study examined the time course of young people's engagement in simulated and monetary gambling, and associations between simulated gambling and gambling problems and harm. A necessary, although not sufficient, condition for simulated games leading to real money gambling is that simulated play must come first.MethodParticipants were 1,026 young adults (aged 18–25 years) who played video games in the last year. They reported the age at which they first took part in seven simulated and twelve monetary gambling products, and current gambling problems and harm.ResultsFirst use of loot boxes and video games with gambling content tended to precede monetary gambling. Forms where gambling is a core gameplay element, such as social casino and demonstration games, tended to follow some monetary gambling forms. Engagement in most simulated gambling products was associated with greater harm from monetary gambling.DiscussionThe findings leave open the possibility of a catalyst pathway from youth engagement in loot boxes and games with gambling content to later monetary gambling, but causal psychosocial mechanisms remain unclear. However, a pathway from social casino and demonstration games to monetary gambling appears less likely, which may instead reflect containment or substitution effects. Simulated gambling disproportionately attracts youth who are vulnerable to gambling problems and harm, indicating the need for consumer protection measures.
Kontestasi dan Kontekstualisasi Filsafat Islam di Tengah Modernitas
Authors: Mohamad Za'in Fiqron  
Published: November 2023

Modernity is characterized by the growth and development of science and knowledge since the Renaissance movement occurred. As is known, there is a strong impression that Islamic philosophy has stopped after Ibn Rushd. There are even claims that Islamic philosophy has suffered a setback. This article aims to explain the contextualization of Islamic philosophy in the modern world and answer the challenges of modernity. This article includes qualitative research with a library model. The data is taken from various literature on Islamic philosophy, especially the latest references. Then it was analyzed using Heidegger's facticity hermeneutic method. Application in this study, the author tends to focus on the tendency of readers of various texts related to the topic of this article. The results of this study show that Islamic philosophy is able to respond to the splendor of modernity, namely the presence of a dialogue between tradition and modernity. In this way, intellectual heritage is not defeated by the development of modernity, but is contextualized by way of reconstruction or deconstruction. This reading is interesting because Islamic philosophy should receive special attention in the midst of the onslaught of science and secularization. So that the reading of Islamic philosophy is not obsolete, but needs further contextualization.
Income and the sense of happiness in the light of empirical research
Authors: Banaszek Marcin 
Published: November 2023

Background: This paper examines the role of subjective well-being as a factor motivating people in the Aristotelian and popular economic perspectives. Both imply that at a deeper level, all human endeavours are intended to increase happiness, although the role of utility in decision-making should not be understated.
Research objectives: The primary aim of the study was to determine whether and if so, what links exist between the income levels of the surveyed residents of Świętokrzyskie Voivodship (a province in south-central Poland) and their self-reported sense of happiness.
Research design and methods: The theoretical part of the study draws on a critical literature review, including selected methods for measuring subjective well-being, whereas the empirical one employs a diagnostic survey based on a questionnaire as a research tool. To analyse the data, descriptive statistics were obtained and a correlation study was performed.
Results: Empirical research reveals that respondents with higher incomes report a higher sense of happiness, but only up to PLN 3,000. Further income increases no longer result in proportional increases in perceived happiness.
Conclusions: Awareness of the relationship between income and happiness can affect financial decision-making, including the motivation to ensure material security, which has a positive impact on the overall quality of life.
Anthropometric features and functional state of the cardiovascular system in qualified athletes of various sports
Authors: Garganeeva N. P. , Taminova I. F. , Kalyuzhin V. V. , Kalyuzhina E. V. , Smirnova I. N. , Sarycheva T. V. 
Published: November 2023

Aim. To assess the anthropometric characteristics and functional state of the cardiovascular system in qualified athletes of various sports.Material and methods. A total of 136 male athletes were examined. Qualified athletes (n=116) (age, 22,07±4,10 years, sports experience 9,56±3,08 years) were divided into groups: I (n=30) — wrestling, judo, II (n=27) — cross-country skiing, biathlon, III (n=33) — powerlifting, IV (n=26) — volleyball. Control group (n=20) consisted of those training less than 3 years. We performed anthropometry with assessment of body height and weight, chest circumference, body surface area, body mass index (BMI), Pignet index, Erisman index, grip and back strength test. Echocardiography, cycle ergometry with assessment of physical working capacity (PWC170) and maximum oxygen consumption (MOC). The relationship between traits was assessed using the Spearman rank correlation coefficient (rs). Critical significance level was p=0,05.Results. According to echocardiography, qualified athletes had significant differences in structural parameters. Group II was characterized by an increase in left ventricular (LV) volumetric dimensions and identified correlations of BMI and body surface area with end-diastolic dimension (r=0,602), end-diastolic volume (r=0,591), end-systolic volume (ESV) (r=0,429), stroke volume (r=0,597), PWC170 (r=0,550). Groups I and III were characterized by an increase in LV posterior wall (LVPWT) and interventricular septal (IVST) thickness. In group I, there was a relationship between body surface area and LVPWT (r=0,413); Pignet index with MOC (r=0,623); PWC170 with Erisman index (r=0,573), strength of the right (r=0,610) and left hand (r=0,515), back muscles (r=0,445). Group III had the highest BMI and body surface area, while relationships were identified with LVPWT (r=0,426), IVST (r=0,409), LV mass (LVM) (r=0,453), and back muscle strength (r=0,464); the Erisman index correlated with LVM index (r=0,359). In group IV, the parameters of height, body weight and body surface area are interrelated with LVM (r=0,731), LVPWT (r=0,523), IVST (r=0,399), ESV (r=0,504), end-systolic dimension (r=0,467), right hand strength (r=0,583).Conclusion. The relationships established by correlation analysis showed that anthropometric features are important components and criteria for assessing cardiac hemodynamics function in qualified athletes, depending on the type of sport and the duration of training, which must be taken into account when achieving sports results.
Practical use of idarucizumab
Authors: Ramazanov G. R. , Kovaleva E. A. , Klychnikova E. V. , Petrikov S. S. , Shamalov N. A. , Aliev I. S. , Shevchenko E. V. 
Published: November 2023

The number of patients with indications for direct oral anticoagulants (DOACs) to prevent thrombotic events is steadily growing. However, in 1,1-2,2% of cases, ischemic strokes occur within DOAC therapy. In this case, DOAC use is a limitation for systemic thrombolysis, except for available reversal of anticoagulation. In order to immediately inactivate the anticoagulant effect of dabigatran etexilate (DE), reversal agent idarucizumab is used.Aim. To evaluate the effectiveness and safety of idarucizumab in clinical practice.Material and methods. The study included 9 patients taking DE who developed urgent conditions that required emergency reversal of anticoagulation with idarucizumab.Results. Normalization of thrombin time (TT) was achieved in 7 (77,8%) patients immediately after idarucizumab administration. In two patients, 10 minutes after the administration of a specific DE reversal agent, TT decreased, but did not reach reference values (case 1: TT decreased from 181 to 23,3 seconds; case 2: TT decreased from 181 to 18,3 seconds); 30 minutes after the idarucizumab administration, TT normalization was achieved.Conclusion. Nobody developed clinically significant arterial and/or venous thrombotic events during the entire period of hospitalization. Rapid reversal of anticoagulation with idarucizumab allows immediate systemic thrombolytic therapy or surgery in patients taking DE without the increase of bleeding or thrombosis risk and the need for control coagulation analysis.
An 8-Year-Old Girl with Drug Hypersensitivity to First Triptorelin Acetate Administration
Authors: Jung Nayoung , Lee Ji Eun , Lim Dae Hyun , Kim Jeong Hee 
Published: November 2023

Triptorelin is a synthetic gonadotropin-releasing hormone agonist for the treatment of precocious puberty in children. Among the triptorelin side effects, drug hypersensitivity reactions, including anaphylaxis, can rarely occur, mostly after repeated exposure to the drug. We present a first case of an 8-year-old girl with central precocious puberty who developed anaphylaxis to the first injection of decapeptyl depot, which contains triptorelin acetate (D,L lactide coglycolide), dextran 70, and polysorbate 80. She showed 2 positive reactions in an intradermal test to decapeptyl depot, suggesting that it is an IgE-mediated reaction to one of its components. Considering this was the first exposure to triptorelin, it might be a reaction to polysorbate. As there are many therapeutic products containing polysorbate which can cross-react with polyethylene glycols, physicians should pay attention to immediate reactions to drugs containing polysorbate.
Tendências de Learning Analytics em Moodle: uma Revisão Sistemática
Authors: Porto Bruno , Dias Dainer Marçal , Battestin Vanessa 
Published: November 2023

O Learning Analytics é o campo de estudo que utiliza métodos analíticos e tecnologias da informação para coletar, analisar e interpretar dados relacionados ao processo de aprendizagem. A relação entre Learning Analytics e Moodle é bastante significativa. Através do Moodle, é possível coletar uma grande quantidade de dados sobre o envolvimento dos alunos, seu desempenho, interações, entre outros aspectos relevantes. Diante disso, este trabalho apresenta os resultados da Revisão Sistemática da Literatura (SLR), que analisou 24 estudos selecionados nas bases da Abed, IEEE, SBC, ScienceDirect, SCOPUS e SpringerLink. Os resultados mostraram que análise de evasão, desempenho, personalização, autorregulação e conclusão de curso são as principais áreas de pesquisa, evidenciando o uso frequente de dados no Moodle para descoberta de padrões e predições. Destacando-se o potencial para melhorar o rendimento acadêmico, reduzir a evasão escolar, personalizar o ensino, aprimorar a interação e aumentar o engajamento dos alunos.

Palavras-chave: Learning analytics. Moodle. Revisão sistemática.
KINETICS AND DYNAMICS OF CLEANING EFFICACY, ANTI-INFLAMMATORY AND REMINERALIZING EFFECTS OF THE NEW NO-SMOKING TOOTHPASTE
Authors: Elovicova Tat'yana , Ermishina Elena , Ssablina Svetlana , Griroriev Sergey , Mandra Yuliya , Koshchev Anatoly , Gegalina N. , Kozmenko Anastasia 
Published: November 2023

Subject. The subject of this study is DentaSwiss Stop Smoking toothpaste.
Objective. The objective of this study is to define kinetic and dynamic features of cleaning efficacy, remineralizing and anti-inflammatory effects of the new no-smoking toothpaste.
Methodology. Study participants included 56 volunteers, young patients (26 males, 30 females; the average age of patients was 21.5 ± 1.75 years). The four groups were formed with 14 patients in each group: the first group included smoking patients brushing teeth with DentaSwiss Stop Smoking; the second group included smoking patients brushing teeth with the placebo toothpaste for oral hygiene; the third group included non-smoking patients brushing teeth with DentaSwiss Stop Smoking; the fourth group included non-smoking patients brushing teeth with the placebo toothpaste for oral hygiene. All study participants were evaluated for dental index values and mixed saliva characteristics. Delivery kinetics of DentaSwiss Stop Smoking components containing calcium (KK-component “functional calcite”) was measured using the diffusion apparatus. Diffusion rate in the toothpaste suspension was calculated through cellulose acetate semipermeable membrane. Organoleptic properties of the new toothpaste were evaluated using 10-rating scale survey.
Conclusions. The diffusion rate of the new toothpaste was 5.0 ± 0.12 pg/s. The average penetration coefficient was 255 ± 0.12 nm/s, the average diffusion coefficient was 10.71 ± 0.08.10-11 m2/s. Toothpaste particle sizes were 2.07 ± 0.17 nm. Studies of use of the new no-smoking toothpaste demonstrated reliable improvement of indices which was evidenced by the increase in pH. On all parameters, organoleptic properties of DentaSwiss Stop Smoking toothpaste were highly ranked by the study participants scoring the average of 9.99 ± 0.01.
WORK LIFE BALANCE DAN WORK ENGAGEMENT : DAMPAKNYA TERHADAP KEPUASAN KERJA DAN KINERJA KARYAWAN
Authors: Latifah Nimas Sayekti  , Suhartini  
Published: November 2023

This study aimed to analyze the effects of WLB and WE on employee satisfaction with job satisfaction as an intervening variable at PT. Antam Tbk Head Office. The data collection method was questionnaires. The population of this study consisted of 321 employees, with a sample consisting of 178 employees. The data analysis method was Structural Equation Modeling (SEM) using SmartPLS v.3.0. The results of the study showed that, first, WLB has a positive effect on job satisfaction. Second, WE has a positive effect on job satisfaction. Third, WLB has a positive effect on employee performance. Fourth, WE has a positive effect on employee performance. Fifth, job satisfaction has a positive effect on employee performance. Sixth, WLB has a positive effect on employee performance through job satisfaction. Seventh, WE has a positive effect on employee performance through job satisfaction. The results of this study can be used as a reference for improving and maintaining WLB, WE, job satisfaction, and employee performance.
Keywords: Work Life Balance, Work Engagement, Performance, and Satisfaction
Low-pressure gasoline direct injection system development and emissions analysis for a reciprocating two-stroke engine
Authors: Gutiérrez Ernesto , Sala Desrideri , Delpeuch Joann 
Published: November 2023

Abstract

This study presents the design and construction of an electronic low-pressure gasoline direct injection system for two-stroke engines, with the objective to study engine performance and the emission of exhaust polluting gases, maintaining the expectations of this type of engine. The investigation includes a test bench with an incorporated engine and the required control devices for this, as well as a gas analyzer Class 0, a Computerized Data Acquisition and several tools for displaying and process all the electronic signals from the engine in real time. In order to manage this system, a custom electronic injection control unit has been designed and built, which allows control the fuel injection timing and duration. This unit uses the signal from an inductive sensor installed in the crankshaft as a reference and synchronization point. Additionally, modifications have been made to the fuel feeder circuit and the electronic of the test engine, as well as to some parts of the mechanism in order to adapt them to this technology. The implementation of the engine tests is described, and the performance and operational points of the original system and those of the new injection system are evaluated.
Rheology Control and 3D Concrete Printing with Fly ash-based Aqueous Nano-silica Enhanced Alkali-activated Binders
Authors: Kamakshi Tippabhotla A. , Kolluru Subramaniam V.L. 
Published: November 2023

Abstract

Efficient alkali-activated binder pastes of slag and fly ash-based aqueous nano-silica (FABANS) that provide enhanced strength are used for developing extrusion-based 3D printing applications. The binder pastes of slag made with FABANS are not suitable for printing due to low yield stress and insufficient thixotropy. Rheology control for enhancing the yield stress and thixotropic buildup is evaluated using bentonite clay and carboxymethyl cellulose (CMC). There is a synergistic enhancement in yield stress and thixotropic buildup provided by the combined use of bentonite and CMC that provides improved printability and buildability. Very rapid increase in yield stress with excess clay content in the presence of CMC, however, produces choking of flow and printability loss. The proportion of CMC and clay that provides the required thixotropic buildup for buildability is established. Printability and buildability of concrete mixture made with binder paste of FABANS with the proportion of rheology modifiers is demonstrated.