bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic deconvolution of embryonic and maternal cell-free DNA in spent culture medium of human preimplantation embryos through deep learning
Authors: Zhang Zhenyi , Qiao Jie , Chen Yidong , Zhou Peijie 
Published: January 2025

AbstractNoninvasive preimplantation genetic testing for aneuploidy based on embryonic cell-free DNA (cfDNA) released in spent embryo culture media (SECM) has brought hope in selecting embryos that are most likely to implant and grow into healthy babies during assisted reproduction. However, maternal DNA contamination in SECM significantly hampers the reliability of embryonic chromosome ploidy profiles, leading to false negative results, particularly at high contamination levels. Here, we present DECENT (deepcopy number variation (CNV) reconstruction), a deep learning method to reconstruct embryonic CNVs and mitigate maternal contamination in SECM from single-cell methylation sequencing of cfDNA. DECENT integrates sequence features and methylation patterns by combining convolution modules, long-short memory, and attention mechanisms to infer the origin of cfDNA reads. The benchmarking study demonstrated DECENT’s ability to estimate contamination proportions and restore embryonic chromosome aneuploidies in samples with varying contamination levels. In contaminated SECM clinical samples, including one with more than 80% maternal reads, DECENT achieved consistent CNV recovery with invasive tests. Overall, DECENT contributes to enhancing the diagnostic accuracy and effectiveness of cfDNA-based noninvasive preimplantation genetic testing, establishing a robust groundwork for its extensive clinical utilization in the field of reproductive medicine.
Phase transition of spindle pole localized protein orchestrates nuclear organization at mitotic exit
Authors: Rajeevan Ashwathi , Olakkal Vignesh , Balakrishnan Madhumitha , Chakrabarty Dwaipayan , Charon François , Noordermeer Daan , Kotak Sachin 
Published: January 2025

AbstractAnimal cells dismantle their nuclear envelope (NE) at the beginning and reconstruct it at the end of mitosis. This process is closely coordinated with spindle pole organization: poles enlarge at mitotic onset and reduce size as mitosis concludes. The significance of this coordination remains unknown. Here, we demonstrate that Aurora A maintains a pole-localized protein NuMA in a dynamic state during anaphase. Without Aurora A, NuMA shifts from a dynamic to a solid phase, abnormally accumulating at the poles, leading to chromosome bending and misshaped nuclei formation around poles. NuMA localization relies on interactions with dynein/dynactin, its coiled-coil domain, and intrinsically disordered region (IDR). Mutagenesis experiments revealed that cation-π interactions within IDR are key for NuMA localization, while glutamine residues trigger its solid-state transition upon Aurora A inhibition. This study emphasizes the role of the physical properties of spindle poles in organizing the nucleus and genome post-mitosis.
Sulfoquinovose is differently degraded by the mouse and human gut microbiota and not metabolized by the host
Authors: Krasenbrink Julia , Hanson Buck T. , Weiss Anna S. , Borusak Sabrina , Tanabe Tomohisa Sebastian , Lang Michaela , Aichinger Georg , Hausmann Bela , Berry David , Richter Andreas , Marko Doris , Mussmann Marc , Schleheck David , Stecher Bärbel , Loy Alexander 
Published: January 2025

AbstractSulfoquinovose (SQ) is a green-diet-derived sulfonated glucose and a selective substrate for few human gut bacteria. Complete anaerobic SQ degradation via interspecies metabolite transfer to sulfonate-respiring bacteria produces hydrogen sulfide, which has dose- and context-dependent health effects. Here, we studied potential SQ degradation by the mammalian host and the impact of SQ supplementation on human and murine gut microbiota diversity and metabolism.13CO2breath tests with germ-free C57BL/6 mice gavaged with13C-SQ were negative. Also, SQ was not degraded by human intestinal cellsin vitro, indicating that SQ is not directly metabolized by mice and humans. Addition of increasing SQ concentrations to human fecal microcosms revealed dose-dependent responses of the microbiota and corroborated the relevance ofAgathobacter rectalisandBilophila wadsworthiain cooperative degradation of SQ to hydrogen sulfide via interspecies transfer of 2,3-dihydroxy-1-propanesulfonate (DHPS). Similar to the human gut microbiome, the genetic capacity for SQ or DHPS degradation is sparsely distributed among bacterial species in the mouse gut.Escherichia coliandEnterocloster clostridioformiswere identified as primary SQ degraders in the mouse gut. SQ and DHPS supplementation experiments with conventional laboratory mice and their intestinal contents showed that SQ was incompletely catabolized to DHPS. Although someE. clostridioformisgenomes encode an extended sulfoglycolytic pathway for both SQ and DHPS fermentation, SQ was only degraded to DHPS by a mouse-derivedE. clostridioformisstrain. Our findings suggest that SQ is solely a nutrient for the gut microbiota and not for mice and humans, emphasizing its potential as a prebiotic. SQ degradation by the mouse microbiota differs from the human gut microbiota by absence of DHPS degradation activity. Hence, the microbiota of conventional laboratory mice does not fully represent the SQ metabolism in humans, indicating the need for alternative model systems to assess the impact of SQ on human health. This study advances our understanding of how individual dietary compounds shape the microbial community structure and metabolism in the gut and thereby potentially influence host health.
Ultralight Dark Matter Search with Space-Time Separated Atomic Clocks and Cavities
Authors: Filzinger Melina , Caddell Ashlee R. , Jani Dhruv , Steinel Martin , Giani Leonardo , Huntemann Nils , Roberts Benjamin M. 
Published: January 2025

We devise and demonstrate a method to search for nongravitational couplings of ultralight dark matter to standard model particles using space-time separated atomic clocks and cavity-stabilized lasers. By making use of space-time separated sensors, which probe different values of an oscillating dark matter field, we can search for couplings that cancel in typical local experiments. This provides sensitivity to both the temporal and spatial fluctuations of the field. We demonstrate this method using existing data from a frequency comparison of lasers stabilized to two optical cavities connected via a 2220 km fiber link [Schioppo , ], and from the atomic clocks on board the global positioning system satellites. Our analysis results in constraints on the coupling of scalar dark matter to electrons, dme, for masses between 10−19 and 2×10−15  eV/c2. These are the first constraints on dme alone in this mass range.

Published by the American Physical Society
2025
Understanding US consumers’ willingness to pay for black walnuts
Authors: Marcillo-Yepez Edgar , Skevas Theodoros , Stubblefield Kelsi , Lin Chung-Ho , Abachi Soheila 
Published: January 2025

PurposeThis study investigates the determinants of consumers’ willingness to pay (WTP) for black walnuts in the US.Design/methodology/approachThe study uses data from a 2023 survey of 916 US consumers and applies an ordered logit regression analysis to assess the determinants of WTP.FindingsIncome, consumption frequency and awareness of the health benefits of black walnuts significantly influence WTP. Moreover, 57% of individuals in our sample are willing to pay more for black walnuts than the current market price for English walnuts, the main competitor, highlighting a substantial market opportunity for black walnuts.Originality/valueThe demand for nuts, both domestically and globally, has seen a remarkable increase in recent years, largely driven by their perceived health benefits across various consumer segments. However, not all nut varieties have experienced commensurate growth, leading to a need for detailed analysis of consumer preferences, particularly for nuts with slower growth trajectories, such as those within the walnut industry. Within the walnut industry, black walnuts (Juglans nigra) stand out with unique production and commercialization dynamics – sourced predominantly from wild trees, boasting distinctive flavors and health benefits, yet facing significant challenges such as limited commercial scale, lower yields and the presence of only one processor in the US. These factors highlight the substantial market potential for black walnuts and make studying this unique crop essential for stakeholders across the nut industry who are interested in enhancing the competitiveness of the black walnut industry.
Punctuality and customer satisfaction in attended home delivery: the moderation effects of price-promotional, emotional and pandemic events
Authors: Duarte André Luís de Castro Moura , Teixeira Rafael , Araujo Fausto Vinicius Martin , Picanco Rodrigues Vinicius 
Published: January 2025

PurposePunctuality has become a critical customer satisfaction feature in attended home deliveries (AHDs). Since much of a customer’s satisfaction is built upon expectations, the purchase context plays a key role, particularly in the face of recurrent or sporadic events. This study has two purposes. First, we investigate the effect of punctuality on customer satisfaction for online purchases with AHDs. We divided punctuality into three dimensions: objective punctuality, perceived punctuality and perceived latency. Second, we explore the moderating effects of the contextual purchasing constructs on the relationship between punctuality and customer satisfaction: price-promotional, emotional and pandemic events.Design/methodology/approachSecondary data were collected from a large multinational appliance manufacturer in Brazil. The dataset contains 233,839 sales and customer satisfaction responses for online purchases requiring AHD. To analyze the data, we used multiple linear regression models with interactions.FindingsThe results showed that all three punctuality dimensions directly affect customer satisfaction. The findings also revealed that all three events moderate the relationship between punctuality and customer satisfaction. Price promotional and pandemic events moderately affect perceived punctuality and lateness, while emotional events moderately affect them.Originality/valueThis study provides a deeper understanding of punctuality for AHDs, breaking punctuality into two perceptual and one objective dimension and assessing their effects on customer satisfaction. In addition, this study introduces three contextual moderating constructs that affect the relationship between punctuality and customer satisfaction. These findings contribute to the last-mile delivery strategy because retailers can manage their resources to match punctual delivery needs.
Digital twin technology for education, training and learning in construction industry: implications for research and practice
Authors: Omrany Hossein , Al-Obaidi Karam M. , Ghaffarianhoseini Amirhosein , Chang Rui-Dong , Park Chansik , Rahimian Farzad 
Published: January 2025

PurposeThis study explores the potential of digital twin (DT) technology to enhance education and training in the construction industry. It aims to provide a clear understanding of how DT can be applied for educational purposes and proposes a framework to facilitate the adoption of DT in construction training.Design/methodology/approachA systematic literature review was conducted to examine the current applications of DT technology in construction education and training. A total of 19 relevant studies were identified and analysed to evaluate the tools, technologies, educational objectives and integration methods used in developing DT models for the construction sector. Based on this analysis, a conceptual framework was developed to guide the integration of DT technology into construction education, addressing gaps in the current literature and practices.FindingsThe analysis revealed a strong consensus on the effectiveness of DT technology in supporting education and training objectives within the construction industry. The study highlighted the fragmented nature of the current literature and proposed a comprehensive framework designed to facilitate the integration of DT in construction education. This framework offers a structured approach to bridging the gap between theoretical learning and real-world application.Originality/valueThe research presents a new systematic framework developed based on an in-depth review for utilising DT in education, training and learning (ETL) processes in construction. The framework provides a novel and structured learning process to integrate theoretical knowledge with practical skills to support workforce development in the construction industry. This framework offers a structured roadmap for future research and practical applications.
The role of carbon emissions in the growth of fossil fuel industries: evidence from an emerging nation
Authors: Gogoi Nivaj 
Published: January 2025

Purpose
This study aims to investigate the relationship between carbon emissions and the industrial growth of India’s core fossil fuel industries (coal, crude oil and natural gas). As a developing economy, India is burdened with various challenges in balancing industrial growth with a healthy environment.

Design/methodology/approach
The weighted least squares regression is applied for this study depending on the suitability of the panel data set from 2005 to 2021. Carbon emission levels are considered to measure the industries’ environmental degradation level, and the Index of Eight Core Industries is considered the indicator of industrial growth of the respective industries. Moreover, other control variables such as economic growth, financial development efficiency, renewable energy consumption level and rent of fossil fuels are included in the empirical models.

Findings
The empirical results suggest that increased emission levels contribute to the growth of India’s core fossil fuel industries. As fossil fuels are considered environmentally harmful energy sources, it is even more challenging for developing economies such as India to achieve industries’ growth without causing adverse effects on the environment. Installing advanced technologies and reducing major reliance can help India to avoid such environmental downturns from the fossil fuel industries’ operations.

Originality/value
The existing literature could not find earlier studies that have analysed the role of industrial emissions in their growth, especially in the Indian context. More studies in similar settings must be conducted to consider the environmental dimensions of various industries to create a healthier future.
Exploring the role of green intellectual capital and HRM: green innovation and environmental performance intensify competitive advantage
Authors: Shahbaz Muhammad Hamid , Malik Shahab Alam 
Published: January 2025

Purpose
The purpose of this study is to focus on Pakistan’s food manufacturing enterprises and explore the knowledge and implications of green innovation, green intellectual capital (GIC) and green human resource management (GHRM) in achieving environmental performance and competitive advantage.

Design/methodology/approach
Using a quantitative approach, this research adopted a cross-sectional survey design to facilitate an objective and precise evaluation of the proposed relationships. The demographic comprised managers and supervisors from food manufacturing enterprises in Lahore, Pakistan. Through purposive sampling, 281 respondents were selected, ensuring representation from food enterprises.

Findings
This study explores that GIC is vital for implementing sustainable technologies in Pakistan’s food sectors. GIC and human resource management are identified as accelerators for green innovation, potentially providing an enhanced environmental performance and competitive edge.

Practical implications
By recognizing the potential of green practices as strategic resources, managers in the Pakistani food sector invest in fostering intangible resources and GIC. This approach leads to sustainable market dominance and efficient operations through continuous green innovation and effective stakeholder communication.

Originality/value
This research offers a consolidated view of the function of GIC in encouraging green innovations in Pakistan’s food enterprises, emphasizing the importance of GHRM procedures and sustainable business methods. This study also provides insights into the strategic management of green projects from a managerial perspective, emphasizing the need for alignment with company strategy and stakeholder communication.
Transforming humanitarian supply chains with digital twin technology: a study on resilience and agility
Authors: Singh Rohit Kumar 
Published: January 2025

PurposeThe study examines the role of how Digital Twin Technology and stakeholder collaboration in enhancing supply chain resilience and agility, specifically within humanitarian aspects. The author used theoretical lenses of Resource-Based View to understand how combining advanced technological resources and relational resources could lead a firm towards better supply chain performance in conditions of volatility and complexity.Design/methodology/approachThe study employs a quantitative research approach, utilizing structural equation modeling (SEM) to analyse data collected from key stakeholders involved in humanitarian supply chains. The model tests the relationships between Digital Twin Integration, stakeholder collaboration and the resulting supply chain outcomes, that is resilience and agility.FindingsThe findings indicate that Digital Twin Technology notably improves supply chain resilience and agility driven by real-time sensing, predictive analytics and process alignment. Additionally, stakeholder collaboration plays a mediator role in enabling organizations to gain full benefits of DTT. The research corroborates the importance of a combined use of technological and relational resources to enable an agile and resilient supply chain, especially in humanitarian settings.Originality/valueThe research makes a novel theoretical contribution by extending the Resource-Based View to appreciate advanced technologies like Digital Twin Technology and their integration in supply chains. The study presents a comprehensive model that integrates technology, collaboration, agility and offers new perspectives on the value of stakeholder engagement to ensure technological innovation delivers its optimum benefits.
Strategies for technology and culture integration for effective remote work
Authors: Reshma M. , Baral Rupashree , Dey Chitra 
Published: January 2025

Purpose
Remote work presents a significant opportunity to redefine the future of work and the workplace. This paper aims to examine how workplace culture and technology can be leveraged to make remote work a viable and long-term solution by using the theoretical lenses of social presence and social shaping of technology (SST).

Design/methodology/approach
Data was collected through semi-structured interviews with 24 full-time employees working remotely and analysed using the Gioia method for qualitative analysis.

Findings
Technology and culture have enabled remote work and afforded benefits to remote workers. However, the new work environment raises new challenges for technology and culture to solve. The findings indicate that technology plays a key role in enhancing social presence, while organisational culture significantly influences how technology is used and developed. As most employees prefer hybrid work arrangements for the future, this study proposes strategies to address and mitigate the challenges associated with remote work.

Originality/value
This paper examines how two ubiquitous aspects of work, technology and organisational culture can be leveraged to answer the new challenges raised by remote work. This study suggests strategies to address the challenges associated with remote work, emphasising the need to enhance social presence and highlighting the role of organisational culture in the advancement of technology. This study proposes a conceptual framework for leveraging technology and culture to create an effective remote work environment.
Burns and Scapens’ framework: a 25-year review of insights, challenges, and prospective directions
Authors: Ammar Sameh Farhat , Hiebl Martin R.W. , Quinn Martin 
Published: January 2025

Purpose
Burns and Scapens (2000) (B&S hereafter) offered a well-cited framework conceptualising management accounting change. This paper aims to provide a systematic review of how B&S has been used to inform management accounting research and presents an updated framework as a point of departure for future work.

Design/methodology/approach
A systematic literature review method is used to ascertain various contexts and designs of B&S-based research. After an extensive examination of citations, 77 journal articles published are identified, described and analysed.

Findings
The systematic review shows that the B&S framework has been applied in many contexts, yet its main tenets remain unchallenged. Several researchers have suggested additions and amendments, and this paper synthesises these to an updated framework. Similar theoretical advancements were noted, indicating that future contributions should be grounded in comprehensive reviews of literature.

Research limitations/implications
A limitation is that the analysis is limited to journal articles and the results of the review are contingent on the authors’ reading.

Originality/value
An updated framework is a core contribution, serving as a basis for further advances in the understanding of the complexity of management accounting change/stability. In addition, concrete and fruitful areas for future research are presented.
Designing on metamodels of air traffic management architecture modeling based on multi-frame modeling language
Authors: Tianning Liu , Wang Xuesong , Lu Jinzhi , Tong Yao , Liu Yixiao 
Published: January 2025

PurposeThis paper aims to propose a set of metamodels applicable to the architecture modeling of air traffic management systems|air traffic management system (ATMS) under the UAF methodology. The designing of metamodels also needs to meet modeling requirements for the introduction of new supersonic airliners into the ATMS.Design/methodology/approachIn order to complete the designing of metamodels and the architecture modeling work in the case study, the GOPPRR method and the M0–M3 modeling framework are used in this paper. The design and modeling work carried out in this paper was done in the multi-architecture modeling tool Airdraw.FindingsIn this paper, the set of metamodels applicable to the architecture modeling of ATMS under the UAF methodology was proposed, which has a quantity of 102 object metamodels, eight point metamodels, 98 property metamodels, 41 relationship metamodels, 36 role metamodels and 65 graph metamodels.Originality/valueThe metamodel design proposed in this thesis allows for architectural modeling of the ATMS. Comparing with the traditional method of system engineering, which uses files to define, the model-based ATMS architecture can be updated for different ATMS and different aircraft types by modifying the parameters of the corresponding views or adding relevant supplementary model views in the architecture model library, which greatly improves the compatibility and modifiability of the system definition.