bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of Low- and Moderate-Grade Adverse Events in Patients' Treatment Experience and Treatment Discontinuation: An Analysis of the E1912 Trial
Authors: O'Connell Nathaniel S. , Zhao Fengmin , Lee Ju-Whei , Ip Edward H. , Peipert John Devin , Graham Noah , Smith Mary Lou , Gareen Ilana F. , Carlos Ruth C. , Obeng-Gyasi Samilia , Sparano Joseph A. , Shanafelt Tait D. , Thomas Mary L. , Cella David , Wagner Lynne I. , Gray Robert 
Published: October 2023

PURPOSE

Despite defined grades of 1 to 5 for adverse events (AEs) on the basis of Common Terminology Criteria for Adverse Events criteria, mild (G1) and moderate (G2) AEs are often not reported in phase III trials. This under-reporting may inhibit our ability to understand patient toxicity burden. We analyze the relationship between the grades of AEs experienced with patient side-effect bother and treatment discontinuation
.

METHODS
We analyzed a phase III Eastern Cooperative Oncology Group-American College of Radiology Imaging Network trial with comprehensive AE data. The Likert response Functional Assessment of Cancer Therapy-GP5 item, “I am bothered by side effects of treatment” was used to define side-effect bother. Bayesian mixed models were used to assess the impact of G1 and G2 AE counts on patient side-effect bother and treatment discontinuation. AEs were further analyzed on the basis of symptomatology (symptomatic or asymptomatic). The results are given as odds ratios (ORs) and 95% credible interval (CrI).

RESULTS
Each additional G1 and G2 AEs experienced during a treatment cycle increased the odds of increased self-reported patient side-effect bother by 13% (95% CrI, 1.06 to 1.21) and 35% (95% CrI, 1.19 to 1.54), respectively. Furthermore, only AEs defined as symptomatic were associated with increased side-effect bother, with asymptomatic AEs showing no association regardless of grade. Count of G2 AEs increased the odds of treatment discontinuation by 59% (95% CrI, 1.32 to 1.95), with symptomatic G2 AEs showing a stronger association (OR, 1.75; 95% CrI, 1.28 to 2.39) relative to asymptomatic G2 AEs (OR, 1.45; 95% CrI, 1.12 to 1.89).

CONCLUSION
Low- and moderate-grade AEs are related to increased odds of increased patient side-effect bother and treatment discontinuation, with symptomatic AEs demonstrating greater magnitude of association than asymptomatic. Our findings suggest that limiting AE capture to grade 3+ misses important contributors to treatment side-effect bother and discontinuation.
Universal Germline-Genetic Testing for Breast Cancer: Implementation in a Rural Practice and Impact on Shared Decision-Making
Authors: Shelton Charles , Ruiz Antonio , Shelton Lauren , Montgomery Hannah , Freas Karen , Ellsworth Rachel E. , Poll Sarah , Pineda-Alvarez Daniel , Heald Brandie , Esplin Edward D. , Nielsen Sarah M. 
Published: October 2023

Abstract
Background
Whereas the National Comprehensive Cancer Network (NCCN) criteria restrict germline-genetic testing (GGT) to a subset of breast cancer (BC) patients, the American Society of Breast Surgeons recommends universal GGT. Although the yield of pathogenic germline variants (PGV) in unselected BC patients has been studied, the practicality and utility of incorporating universal GGT into routine cancer care in community and rural settings is understudied. This study reports real-world implementation of universal GGT for patients with breast cancer and genetics-informed, treatment decision-making in a rural, community practice with limited resources.

Methods
From 2019 to 2022, all patients with breast cancer at a small, rural hospital were offered GGT, using a genetics-extender model. Statistical analyses included Fisher’s exact test, t-tests, and calculation of odds ratios. Significance was set at p < 0.05.

Results
Of 210 patients with breast cancer who were offered GGT, 192 (91.4%) underwent testing with 104 (54.2%) in-criteria (IC) and 88 (45.8%) out-of-criteria (OOC) with NCCN guidelines. Pathogenic germline variants were identified in 25 patients (13.0%), with PGV frequencies of 15 of 104 (14.4%) in IC and ten of 88 (11.4%) in OOC patients (p = 0.495). GGT informed treatment for 129 of 185 (69.7%) patients.

Conclusions
Universal GGT was successfully implemented in a rural, community practice with > 90% uptake. Treatment was enhanced or de-escalated in those with and without clinically actionable PGVs, respectively. Universal GGT for patients with breast cancer is feasible within rural populations, enabling optimization of clinical care to patients’ genetic profile, and may reduce unnecessary healthcare, resource utilization.
Editorial
Authors: Gimenez Fernando Antonio Prado , Coelho Arnaldo Fernandes Matos , Weersma Laodicéia Amorim 
Published: October 2023

EDITORIAL: EMPREENDEDORISMO, CIÊNCIA, INOVAÇÃO, TECNOLOGIA E DESENVOLVIMENTO SUSTENTÁVEL Desde que Schumpeter apresentou suas ideias seminais sobre empreendedorismo enquanto manifestação de novas combinações de recursos e forças, concretizando alterações na produção, a inovação tem sido considerada central a esse fenômeno. Assim, por meio da concepção Schumpeteriana do indivíduo empreendedor, tornaram-se clássicas as cinco possíveis formas de inovação presentes na ação empreendedora: (i) introdução de novos produtos; (ii) criação de novos métodos de produção; (iii) abertura de um mercado novo; (iv) identificação de novas fontes de suprimento; e (v) criação de novas organizações. [...]
Role of maternal serum c-reactive protein levels in early second trimester as a marker of preterm labour: A study protocol
Authors: Gudapati Sravya , Chaudhari Kamlesh 
Published: October 2023

Preterm labour is a birth that occurs between 22 and 37 weeks after conception. The primary cause of infant death is preterm birth (PTD), which is linked to long-term neurodevelopmental and behavioural effects for preterm survivors. A maternal vascular disease pathway and an inflammation/infection pathway are two suggested pathways that have collected sufficient evidence. The identification of women who are more likely to develop PTD and the understanding of the underlying physiological mechanisms would be made possible by reliable biomarkers for these pathways. Systemic maternal infections cause elevated levels of inflammatory cytokines, which then drive the creation of prostaglandins, which can cause cervical ripening and uterine contractions that result in preterm birth. Women with signs of preterm labour have been found to have high serum levels of proinflammatory which have been prospectively linked to preterm birth. A non-specific biomarker of inflammation, C-reactive protein (CRP) is an acute phase reactant in the innate immune response. The production of C-reactive protein, a serological marker that is readily identifiable, occurs largely in the hepatocytes in response to cytokine releases from the inflammatory site. Cytokines released, by an intrauterine infection go through the maternal bloodstream to the liver, where they activate the production of CRP. Forty-eight hours after stimulation the acute-phase response has reached its maximum and a meaningful measurement can be made from a blood sample. Although the exact cause of inflammation is unknown, modest and long-lasting elevations of CRP have been linked to a range of illnesses, including normal pregnancy. Elevated CRP levels in the peripheral circulation have been connected to the presence of intrauterine infection. It has been investigated to diagnose subclinical infections using the maternal CRP concentration. The purpose of this study is to determine the link between maternal serum CRP and subsequent preterm birth in single pregnant women.
Heterogenous transmission and seroprevalence of SARS-CoV-2 in two demographically diverse populations with low vaccination uptake in Kenya, March and June 2021
Authors: Munywoki Patrick K. , Bigogo Godfrey , Nasimiyu Carolyne , Ouma Alice , Aol George , Oduor Clifford O. , Rono Samuel , Auko Joshua , Agogo George O. , Njoroge Ruth , Oketch Dismas , Odhiambo Dennis , Odeyo Victor W. , Kikwai Gilbert , Onyango Clayton , Juma Bonventure , Hunsperger Elizabeth , Lidechi Shirley , Ochieng Caroline Apondi , Lo Terrence Q. , Munyua Peninah , Herman-Roloff Amy 
Published: October 2023

Background: SARS-CoV-2 has extensively spread in cities and rural communities, and studies are needed to quantify exposure in the population. We report seroprevalence of SARS-CoV-2 in two well-characterized populations in Kenya at two time points. These data inform the design and delivery of public health mitigation measures. Methods: Leveraging on existing population based infectious disease surveillance (PBIDS) in two demographically diverse settings, a rural site in western Kenya in Asembo, Siaya County, and an urban informal settlement in Kibera, Nairobi County, we set up a longitudinal cohort of randomly selected households with serial sampling of all consenting household members in March and June 2021. Both sites included 1,794 and 1,638 participants in March and June 2021, respectively. Individual seroprevalence of SARS-CoV-2 antibodies was expressed as a percentage of the seropositive among the individuals tested, accounting for household clustering and weighted by the PBIDS age and sex distribution. Results: Overall weighted individual seroprevalence increased from 56.2% (95%CI: 52.1, 60.2%) in March 2021 to 63.9% (95%CI: 59.5, 68.0%) in June 2021 in Kibera. For Asembo, the seroprevalence almost doubled from 26.0% (95%CI: 22.4, 30.0%) in March 2021 to 48.7% (95%CI: 44.3, 53.2%) in July 2021. Seroprevalence was highly heterogeneous by age and geography in these populations—higher seroprevalence was observed in the urban informal settlement (compared to the rural setting), and children aged <10 years had the lowest seroprevalence in both sites. Only 1.2% and 1.6% of the study participants reported receipt of at least one dose of the COVID-19 vaccine by the second round of serosurvey—none by the first round. Conclusions: In these two populations, SARS-CoV-2 seroprevalence increased rapidly in the first 16 months of the COVID-19 pandemic in Kenya. It is important to prioritize additional mitigation measures, such as vaccine distribution, in crowded and low socioeconomic settings.
ENSEÑANZA INTERDISCIPLINARIA MÚSICA-MATEMÁTICA: LA GUITARRA Y SU ROL PROTAGÓNICO EN EL DESARROLLO HISTÓRICO DE LA MÚSICA OCCIDENTAL
Authors: Espinoza Ramírez Lianggi , Vergara Gómez Andrea 
Published: October 2023

El temperamento igual es la afinación estándar de instrumentos en Occidente y ha delineado nuestra actual manera de concebir la música. El propósito de esta investigación es explorar cómo los conocimientos puestos en uso y significados asociados al surgimiento histórico del temperamento igual en instrumentos antecesores a la guitarra pueden contribuir a un enfoque interdisciplinario para el aprendizaje de la matemática y la música. Para esto se realizó un análisis interpretativo del contenido del libro Armonía universal de Mersenne de 1637, y se estudió el proceso de génesis y desarrollo en el siglo XVI de los saberes presentes en este libro. Los resultados revelan que es posible repensar la enseñanza de algunos contenidos geométricos a nivel escolar, como el teorema de Euclides y la progresión geométrica, a partir del problema de la división proporcional del mástil de la guitarra. Se revela, además, que la noción de autosimilitud permitiría generar propuestas didácticas interdisciplinarias, que propicien una vinculación transversal entre la Matemática y la Música.
REVISIÓN CURRICULAR DE LOS TEMAS DE ESTADÍSTICA EN EDUCACIÓN PRIMARIA
Authors: López Camilo , Gómez Pedro 
Published: October 2023

En este artículo realizamos una revisión curricular de los temas que se incluyen en estadística en primaria en Colombia y en los 56 países que participaron en TIMSS 2015. Organizamos los temas con base en los conceptos y procedimientos, las representaciones y la fenomenología relacionados con la estadística en educación primaria. Identificamos diferencias y similitudes entre los temas considerados en Colombia y los temas que se abordan en los países participantes en TIMSS 2015. Encontramos que la estadística se incluye en los currículos de la mayoría de estos países. Principalmente, los temas se centran en las representaciones gráfica y tabular, en el concepto de media y en la fenomenología se hace referencia a la estadística para organizar la información. Estos resultados pueden generar discusiones de carácter curricular y motivar a realizar estudios similares en otros países.
Evaluating a specialist palliative care service in a community setting
Authors: Cushen-Brewster Noreen , Malloy Ella , Black Jane , Strudwick Ruth , Driscoll-Evans Paul , Zeppetella Giovambattista , Bengtson Kelvin 
Published: October 2023

Background/Aims In the Norfolk and Waveney Integrated Care System, a community organisation and a hospice have collaborated to develop an innovative specialist palliative care service in a community hospital. The aim of this service evaluation was to review the specialist palliative care service 2 years after implementation began across the integrated care system. Methods A multi-method approach was used to evaluate this service. Data were collected from pre-existing datasets on referrals, discharge and service use and described using descriptive statistics to assess how the service was used during the evaluation period (1 April 2019–31 March 2021). Qualitative data were collected via semi-structured interviews with 25 patients, carers, staff and other stakeholders. Interview transcripts were analysed using thematic analysis. Results During the 2-year evaluation period, the service recorded 1800 referrals, 189 admissions to specialist beds and 19 712 telephone calls to the 24-hour advice line. Thematic analysis of interview transcripts identified four themes: impact of the specialist palliative care beds, implementation of changes to practice, communication and coordination, and challenges related to providing the service. Overall, patients and carers had very positive views of the quality of care they received. Staff also identified benefits, including access to training and improved morale. Challenges included the limited number of beds and difficulties balancing the care needs of palliative care patients with other patients in the inpatient ward. Conclusions The specialist palliative care service promoted collaborative working, leading to enhanced knowledge and skills for staff supporting patients with specialist palliative care needs. The service was well-used and patients and their carers were generally very satisfied with the care they received.
The HPV-TP53-MALAT1 Axis: Unravelling interactions in cervical cancer development
Authors: Iordanishvili Saba , Metreveli Tornike , Lipartia Elene , Gachechiladze Konstantine , Khuntsaria Irakli , Qobulashvili Tamar , Jorbenadze Mariam , Revazishvili Tamaz , Kldiashvili Ekaterina , Kaufmann Andreas Martin 
Published: October 2023

Introduction
Cervical cancer, primarily driven by Human Papillomavirus (HPV) infection, stands as a substantial global health challenge. The TP53 gene’s, Arg72Pro polymorphism has emerged as a noteworthy player in cervical cancer development, particularly among individuals harboring high-risk (HR) HPV types. Additionally, long non-coding RNAs (lncRNAs), exemplified by metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), exert critical roles in cancer biology. This study delves into unravelling the intricate connections linking HPV infection, TP53 Arg72Pro polymorphism, and MALAT1 expression in the context of cervical cancer.

Materials and methods
Within a cohort of cervical cancer patients, we discerned HPV infection statuses, executed genotyping for the TP53 Arg72Pro polymorphism, and quantified MALAT1 expression through quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Statistical analyses meticulously probed relationships intertwining HPV infection, TP53 polymorphism, and MALAT1 expression.

Findings
Our investigation revealed a striking prevalence of the TP53 Arg72Pro polymorphism among HPV-positive subjects, accompanied by a robust and statistically significant correlation linking MALAT1 overexpression (p<0.01) and HR-HPV positivity (p<0.03). Importantly, a subset of MALAT1 overexpression cases unveiled a concomitant TP53 Pro72Pro polymorphism. In contrast, HPV-negative invasive cervical carcinoma samples exhibited no discernible shifts in MALAT1 expression.

Conclusion
The contours of our findings sketch a compelling landscape wherein HR-HPV infection, TP53 polymorphism, and MALAT1 expression intertwine significantly in cervical cancer. The voyage ahead entails delving deeper into molecular underpinnings to decipher MALAT1’s nuanced role and its dance with TP53 within HPV-associated cervical carcinogenesis. This expedition promises insights that may engender targeted therapeutic interventions and bespoke prognostic markers, tailored to the realm of HR-HPV-related cervical cancer.
“ONDE ESTÃO AS PESSOAS TRANS?”: TEMÁTICA DA TRANSGENERIDADE NA GRADUAÇÃO EM ENFERMAGEM
Authors: Morais Andréia Vanessa Carneiro de , Jesus Marília Emanuela Ferreira de , Santos Izabel Conceição , Conceição Lanna Katherine Leitão , Santiago Thalia Nepomuceno Santos , Santana Bianca Conceição Gomes de , Cortes Helena Moraes , Oliveira Jeane Freitas de 
Published: October 2023

Objetivo: Investigar se/como a transgeneridade é abordada nos cursos de graduação em Enfermagem das Universidades Federais Brasileiras. Métodos: Estudo de abordagem qualitativa, de base documental, do tipo analítico-descritivo, que utilizou dados provenientes do portal e-Mec, Projetos Pedagógicos de Curso, ementas de componentes curriculares e informações dos grupos de pesquisas cadastrados no Diretório de Grupos de Pesquisa do Brasil. Resultados: Foram identificadas 51 universidades, das quais 21 abordam a temática da transgeneridade em seu Projeto Pedagógico de Curso e 21 grupos de pesquisa que trabalham com a temática, distribuídos em todas as regiões do Território Nacional. Conclusão: De acordo com os resultados, a temática da transgeneridade vem ocupando espaço nas Universidades Federais Brasileiras, no entanto é imprescindível a ampliação dos espaços de formação, sobretudo incorporando a perspectiva e produção de pesquisadoras/es trans, afim de garantir a pluralidade desse ambiente e subsídio para as futuras atuações profissionais.
Technical, Economic, and Environmental Review of Waste to Energy Technologies from Municipal Solid Waste
Authors: Jamilatun Siti , Pitoyo Joko , Setyawan Martomo 
Published: October 2023

Global municipal solid waste production and electricity demand gradually increased as a result of urbanization, population increase, and economic growth. The appropriate selection of Waste to energy (WTE) technologies needs consideration of energy efficiency, financial, and environmental aspects. This article discusses the technical, financial, and environmental side of existing WTE technologies. Waste-to-energy (WTE) technologies include thermal, physical, biochemical, and bio-electrochemical technology. Pyrolysis, gasification, and incineration are thermal technology used to generate energy from waste in the form of heat and syn-gas. Anaerobic digestion and landfill are biochemical technology to to generate energy from waste in the form of biogas. Physical technology is used to to generate energy from waste in the form of refuse-derived fuel (RDF). Microbial fuel cells (MFC) and microbial electrolysis cells (MEC) are the most recent WTE technology that produces electricity and hydrogen fuel. The results of the assessment of existing technology show that anaerobic digestion and landfill are low-cost WTE technology but have a low potential for energy generation. Plasma gasification is WTE technology with a high potential for energy generation, cold gas efficiency (CGE), carbon conversion efficiency (CCE), and H2/CO ratio, low CO2 emissions, and high operating costs. MEC has a high H2-potential for energy generation, low CO2 emissions, and the highest capital cost. Incineration is a common conversion technology with a low potential for energy generation, high CO2 emissions, and high capital costs. The selection of WTE technologies is influenced by technical, economic, and environmental factors.
Inventarisasi Emisi dari Sektor Transportasi Darat di Kota Pontianak
Authors: Rahmasari Rizki Nur , Jati Dian Rahayu , Jumiati Jumiati 
Published: October 2023

Upaya yang dapat dilakukan untuk mengatasi permasalahan polusi udara yaitu dengan melakukan pengendalian pencemaran udara, salah satunya dengan cara melakukan inventarisasi emisi. Tujuan penelitian ini adalah untuk menghitung beban emisi CO, NOx, SO2, dan PM10 yang dihasilkan oleh sektor transportasi di Kota Pontianak, serta untuk menentukan jenis kendaraan bermotor yang paling berkontribusi dalam menghasilkan emisi tersebut. Penelitian ini dilakukan dengan menggunakan dua pendekatan perhitungan yaitu berbasis VKT dan berbasis konsumsi bahan bakar. Melalui penelitian ini, diharapkan dapat dievaluasi besarnya beban emisi dari sektor transportasi dan diidentifikasi jenis kendaraan bermotor yang perlu mendapat perhatian dalam pengendalian emisi di Kota Pontianak. Penelitian dilakukan di enam kecamatan Kota Pontianak dengan jumlah sampel sebanyak 467 kendaraan bermotor untuk mendapatkan data VKT kendaraan dan konsumsi bahan bakar kendaraan bermotor, dengan jenis kendaraan bermotor yang diteliti yaitu sepeda motor, mobil penumpang, sedan, pikap, dan truk. Hasil penelitian menunjukkan bahwa perhitungan beban emisi di Kota Pontianak dengan pendekatan VKT pada tahun 2020 yaitu menghasilkan CO sebesar 5376.9 ton/tahun, NOx sebesar 365.9 ton/tahun, SO2 sebesar 16.5 ton/tahun, dan PM10 sebesar 69.3 ton/tahun sementara perhitungan beban emisi dengan pendekatan konsumsi bahan bakar pada tahun 2020 yaitu menghasilkan CO sebesar 63059.1 ton/tahun, NOx sebesar 2090.1 ton/tahun, SO2 sebesar 11.3 ton/tahun, dan PM10 sebesar 404.1 ton/tahun. Adapun jenis kendaraan bermotor yang paling berkontribusi dalam menghasilkan emisi CO, NOx, SO2 dan PM10 di Kota Pontianak yaitu: truk, sepeda motor, dan mobil penumpang.
Perolehan Legal Entity dan Legal Product bagi UMKM
Authors: Purwaningsih Endang , Anisariza Nelly Ulfah , Basrowi Basrowi 
Published: October 2023

Pentingnya legal entity dan legal product bagi kegiatan usaha yang kompetitif, tapi masih rendahnya pemahaman pelaku UMKM tentang legal entity dan legal produk yang mereka hasilkan. Penelitian ini membahas bagaimana legal entity dan legal product yang dipahami oleh para pelaku Usaha Menengah Kecil Menengah (UMKM), dan motivasi para pelaku UMKM untuk mendapatkan kedua aspek tersebut. Metode yang digunakan dalam penelitian empiris dengan pendekatan participatoris, pendekatan statute, pendekatan legal-sosiologis, dan sumber data meliputi data primer yang diperoleh langsung dari subjek penelitian. Hasil penelitian membuktikan bahwa literasi atau tingkat pemahaman dan motivasi pelaku UMKM Jawa Tengah terhadap pentingnya legal entity and legal product tinggi dan model yang tepat untuk memotivasi para pelaku UMKM mendapatkan legal entity and legal product, adalah pemberdayaan yang terus menerus dengan melibatkan peran stakeholders antara lain, Dinas Koperasi dan UKM serta dinas terkait, perbankan, notaris, perguruan tinggi, perkumpulan UMKM, dan DUDI. Kesimpulannya, legal entity dan legal product telah dipahami dengan baik oleh pelaku UMKM, dan untuk mendapatkan legal entity dan legal produk perlu dukungan dari semua pihak dan pendampingan dari kampus.