bluuebunny/crossref_metadata_2025_split huggingface dataset:
Granular Cell Tumors of the Larynx: A Systematic Review
Authors: Luke Alex S. , Mairson Theresa M. , Husain Inna A. , Kaplan Seth E. 
Published: October 2023

ObjectiveGranular cell tumor of the larynx is an uncommon, typically benign lesion that may be confused for a malignant neoplasm based on histopathology. This review examines cases of granular cell tumor of the larynx in adults to highlight key distinctions in diagnosis/management and demonstrate how misclassification may lead to unnecessary escalations in therapy.Data Sources and MethodsA systematic search of PubMed, Ovid, and EBSCO Search Hosts was completed in December 2021. The search yielded 501 articles with 87 full‐text articles included in the review. Primary search terms included granular cell, tumor, larynx, and adult. Primary endpoints were patient presentation, primary management, pathological features, and disease course.ResultsA systematic review of 87 articles identified 200 patients with granular cell tumors (GCTs) of the larynx. Of the 200 patients, 50.3% were males and 49.7% were females. Of these, 54.0% were reported as white patients, and 46.0% were reported as black patients. The most common presenting symptoms were dysphonia (85.9%) and stridor/dyspnea (14.1%). On examination, the lesions were most commonly polypoid/nodular and firm. Pseudoepitheliomatous hyperplasia (PEH) was identified in 33.5% of cases, and 2% of cases were malignant. GCTs were misdiagnosed as other malignant lesions in 11% of cases. In benign cases, 13.5% of patients underwent additional surgeries beyond simple excision/laryngofissure, including laryngectomy and neck dissection. Less than 2% of lesions reoccurred.ConclusionGranular cell tumors of the larynx are typically benign lesions that may be misdiagnosed with unnecessary escalation of treatment. However, most lesions resolve via primary surgical excision. Laryngoscope, 134:1523–1530, 2024
Effects of different farmland utilization types on soil organic carbon in China: A meta‐analysis
Authors: Ouyang Xueying , Zhu Liqun 
Published: October 2023

AbstractExploring the relationship between soil organic carbon (SOC) and different farmland utilization types can contribute to achieving carbon neutrality in agriculture. Over the past few decades, numerous researchers have conducted a multitude of studies on the effects of farmland utilization types on SOC in China, and these studies have yielded a wealth of data from field experiments. However, these experiments are limited in that they lack sufficient quantitative analyses of studies conducted on regional or national scales. In this study, we analyzed the three most common farmland utilization types (paddy field [PF], dry land [DL], and vegetable field [VF]) in China using a national‐scale meta‐analysis and included data from 108 observations from 28 studies in the field. In this meta‐analysis, we conducted three comparisons (control vs. treatment): (a) PF versus DL, (b) PF versus VF, and (c) DL versus VF. The results showed that in comparison (a), DL had a significantly lower SOC than PF (ln R++ = −0.463, 95% confidence intervals [CIs] = −0.580 ~ −0.345), with DL showing 37.1% lower SOC than PF. In comparison (b), although there was no statistically significant difference between PF and VF (ln R++ = −0.078, 95% CIs = −0.167 ~ 0.011), VF had 7.5% lower SOC than PF. In comparison (c), VF had significantly higher SOC than DL (ln R++ = 0.227, 95% CIs = 0.147 ~ 0.307), with VF showing 25.5% higher SOC than DL. It should be noted that the effects of farmland utilization types on SOC content observed in China varied depending on different factors such as the regions, climatic conditions, and cropping systems. In conclusion, SOC content could be affected by farmland utilization types. Therefore, in order to promote the development of low‐carbon agriculture in China, it is important to consider farmland utilization types in agricultural production, as well as to consider carbon budgets, food security, and field practices to maximize agronomic and environmental benefits.
Using virtual reality based learning to provide education on the management of diabetes emergencies for doctors in training
Authors: Mallik Ritwika , Pottle Jack , Atkinson Ben , Kar Partha , Patel Mayank 
Published: October 2023

AbstractIt is essential that all doctors in training feel confident in their ability to manage diabetes emergencies occurring in hospital settings. This is particularly pertinent when specialist expertise is not always immediately available, as well as at a time when diabetes prevalence in hospitals is rising.The project team created interactive, immersive scenarios and ran ‘DEVICE’ (Diabetes Emergencies: Virtual Interactive Clinical Education), a pilot study to test the feasibility of using virtual reality (VR) as a safe‐space learning medium for training medical staff on diabetes emergency management. Each study participant worked through two emergency scenarios, under the supervision of a consultant trainer. Analysis of the participants’ performance metrics showed improved clinical approaches and increased confidence in handling diabetes emergencies by these non‐specialist participants.Here we describe this pilot study development in more detail, as well as provide an update following the national roll‐out of these training resources across seven national postgraduate medical deaneries. The DEVICE initiative was found to be scalable and sustainable, with VR‐based learning deemed to be a popular, safe, and effective teaching tool for diabetes. We are now developing VR‐based training cases for use by other health care professionals within primary and secondary care. Copyright © 2023 John Wiley & Sons.
The growing use of continuous glucose monitors in people without diabetes: an evidence‐free zone
Authors: Guess Nicola 
Published: October 2023

AbstractThe use of continuous glucose monitors (CGMs) is growing among people without diabetes, and is being encouraged by CGM manufacturers and personalised nutrition companies alike. This article critically discusses the issues that may arise from this new trend, including pathologising normal post‐prandial glucose excursions, the unnecessary avoidance of healthful foods and the risk of a glucocentric approach to nutrition which could inadvertently increase the risk of cardiometabolic diseases a person is trying to avoid. The theoretical benefits of CGMs in people without diabetes will be discussed, and recommendations for the evidence needed to help realise their potential will be made. Copyright © 2023 John Wiley & Sons.
Digital enabled learning for people with diabetes postCOVID‐19 pandemic
Authors: McDowell Joan RS , Mehar Salma , Chandok Raj S , Watson Wendy A 
Published: October 2023

AbstractThe COVID‐19 pandemic was the catalyst for a rapid increase in digital learning for people with diabetes. This paper aims to discuss the research on digital learning and the impact and synergy of COVID‐19 on health inequalities, and present some digital educational resources. Copyright © 2023 John Wiley & Sons.
Overcoming barriers to technology in special groups
Authors: Alshatti Asmaa , Bishop Katherine 
Published: October 2023

AbstractDiabetes demands a high volume of self‐care and management, which poses many obstacles for those with advanced age, cognitive impairment, or physical disability. The latest diabetes technologies, including smart insulin pens, continuous glucose monitoring and insulin pumps, have great potential to improve glycaemic control and quality of life, particularly for those affected by impairment or disability. Although these groups may face barriers to using diabetes technology, accessing and harnessing the benefits and opportunities of the technologies can be achieved with appropriate support and education. This article explores the role of diabetes technology in the care of individuals in special groups, including those with visual impairment, learning disability, cognitive impairment, or reduced dexterity, and elderly people. Copyright © 2023 John Wiley & Sons.
DFT Study of the SNAr Reactions of 1‐Chloro‐2‐nitro‐ and 1‐Phenoxy‐2‐nitro‐benzenes with Aniline in Acetonitrile and Toluene: Concerted or Multistep Mechanism?
Authors: Oloba‐Whenu Oluwakemi A. , Isanbor Chukwuemeka 
Published: October 2023

AbstractComputational studies to determine the rate constants and thermodynamic properties of the nucleophilic aromatic substitution reactions of 4‐R‐1‐chloro‐2,6‐dinitrobenzenes 1, 6‐R‐1‐chloro‐2,4‐dinitrobenzenes 2 and some of the corresponding 1‐phenoxy derivatives 3 and 4 with aniline in the gas phase, acetonitrile and toluene is reported at the M06‐2x/6‐31g+(d,p) level of theory; R=H, NO2, CF3, CN and ring N. Formation of the Meisenheimer complex intermediate was observed in all cases and its stability was dependent on the number of electron‐withdrawing groups present on the ring and their relative position. The overall reaction was found to be exothermic and exergonic in all cases. From kinetics calculations, the initial attack of the aniline nucleophile on the dinitrobenzene to form the intermediate is rate limiting with the chloride ion as the leaving group in acetonitrile and decomposition of the MC was rate limiting in vacuum and toluene. With the phenoxide ion as the leaving group, the decomposition of the MC intermediate is rate limiting in all cases. The observation of MC and thermodynamic data obtained are suggestive of the prevalence of a multistep SNAr mechanism and ring activation by electron withdrawing group increased the rate of reaction.
Functionalization and Properties of Olive Wood Shell Stone and Its Use in Polyester Biocomposites
Authors: Sánchez‐Sevilla Bernardo , Olmedo‐Navarro Melissa , Pérez Juana M. , Martínez‐Lao Juan A. , Fernández Ignacio 
Published: October 2023

AbstractThe use of olive wood shell stone (OS) as a revalorized agri‐food residue has been investigated for the development of new biocomposites in which a significant amount of the mineral filler is substituted by olive wood stone (APTMS). In addition, we have explored the functionalization of olive stone with different types of coupling agents that are known to improve adhesion between the lignocellulosic matrix and, in our case, unsaturated polyester resin as the most used binder in composite materials. The new functionalized materials have been thoroughly characterized by means of X‐ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectra (ATR and FTIR‐DRIFT), ζ‐potential, elemental analysis, XRF, pore size distribution, differential scanning calorimetry (DSC), thermogravimetric (TG), moisture content and particle size distribution. The mechanical and thermal properties of the resulting composites have been evaluated, showing promising results with very good characteristics in flexural strength and heat deflection temperature (HDT), but with lower Barcol hardness and Young's modulus compared to those based on feldspar as an inorganic filler.
Facilely Synthesized Cobalt Doped TiO2 Graphene Oxide Nanocomposite as an Advanced Photocatalyst Material for Degradation of Methylene Blue
Authors: Altin Ilknur 
Published: October 2023

AbstractIn this work, cobalt activated TiO2 photocatalyst have been successfully prepared on graphene oxide (GO) using simple and cost‐effective method to prepare Co‐TiO2/GO nanocomposites for the photocatalytic treatment of methylene blue (MB), representative organic dye, under visible light irradiation. The as‐prepared samples were characterized by X‐ray diffraction (XRD), High resolution transmission electron microscope (HRTEM), X‐ray photoelectron spectroscopy (XPS), UV‐vis diffused reflectance spectra (DRS), Raman spectroscopy and photoluminescence spectroscopy (PL). The characterization results confirmed that Co‐TiO2 catalyst is decorated on the graphene oxide. The photocatalytic efficiency of Co‐TiO2/GO for the degradation of MB was also improved by changing the proportion between Co‐TiO2 and GO. Highest photocatalytic activity was observed for Co‐TiO2 loaded with 5 wt % GO (88.7 %) compared with neat Co‐TiO2 (43.4 %) after 180 min of visible light irradiation. Furthermore, degradation by products was analyzed on Quadrupole Time‐of‐Flight Liquid Chromatography/Mass Spectroscopy (QTOF/LCMS) and the possible degradation pathway was proposed. It is investigated that the Co‐TiO2/GO nanocomposite has potential use in the catalytic degradation of organic contaminants under visible light irradiation.
Decoration, Characterization and Antimicrobial Activity Evaluation of Novel Nano‐Based 1,2‐Phenylenediamine Functionalized Maleic Anhydride‐Allylphenyl Ether Conjugate
Authors: Karakus Gulderen , Atas Mehmet 
Published: October 2023

Abstract1,2‐Phenylenediamine (o‐PDA) is a well‐known fluorescent dye that enables the decoration of next‐generation chemotherapeutics. A novel o‐PDA‐functionalized maleic anhydride‐allyl phenyl ether (poly(MA‐alt‐APE)/o‐PDA conjugate) was successfully synthesized according to the Ringsdorf model, which is the starting point for macromolecular prodrugs. Functional polymeric‐carriers were prepared by free‐radical polymerization in butyl acetate with azobisisobutyronitrile (AIBN) radical‐initiator at 70 °C. The conjugation was carried out at 40 °C in N,N‐dimethylformamide (DMF) using triethylamine (Et3N) as the conjugation catalyst. Characterization was performed by Attenuated Total Reflectance‐Fourier Transform Infrared (ATR‐FTIR), Nuclear Magnetic Resonance (1H‐NMR), UV‐Vis and Fluorescence Spectroscopy. Weight average molecular weight (Mw), number average molecular weight (Mn) and polydispersity index (PDI) (Mw/Mn) were calculated using gel permeation chromatography (GPC). The surface morphology was also elucidated by Transmission Electron Microscopy (TEM). Evaluation of antimicrobial activity against two Gram‐positive bacteria (Staphylococcus aureus, Bacillus cereus), two Gram‐negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and one yeast Candida albicans was performed using the broth microdilution method according to Clinical Laboratory Standards Institute (CLSI) criteria. Interestingly, S. aureus was found to be more sensitive to polymer‐based samples and, in particular, the minimum inhibitory concentration (MIC) of the conjugate was lower than that of ciprofloxacin used as a control compound.
High Yield and High Volumetric Capacitance Activated Carbons by One‐step Homogeneous Activation of Diaphragma Juglandis Fructus for Supercapacitors
Authors: Wen Xiaoguang , Deng Jiacheng , Hu Sujuan , Chen Yao 
Published: October 2023

AbstractDiaphragma juglandis fructus (DJF) is selected as a precursor of activated carbon (AC). Saturated absorption of solution containing desirable amount of KOH in DJF leads to one‐step homogeneous activation which produces AC‐1 comprising non‐honeycombed smaller particles with lower energy consumption compared with AC‐2 by the conventional two‐step method. The non‐honeycombed morphology of AC‐1 results in a high yield of 24.2 % and a high packing density of 0.78 g cm−3. Although the specific surface area of AC‐1 is only 1030 m2 g−1, the specific capacitance reaches 244 F g−1 at 0.5 A g−1 in 6 mol L−1 KOH in a three‐electrode cell, higher than that of AC‐2 due to the reasonable pore distribution. In a symmetrical supercapacitor with the 6 mol L−1 KOH electrolyte, the maximum specific cell capacitance is 58.1 F g−1 at 0.25 A g−1, corresponding to a high volumetric capacitance of 181 F cm−3 for a single electrode. The flexible supercapacitor with PVA/KOH electrolyte shows areal capacitance of 637 mF cm−2 and can maintain 70 % of the initial value after 180° bending for 400 times. The AC‐1 cell with the ionic liquid electrolyte has a maximum specific energy of 30.6 Wh kg−1, which can illuminate 16 light‐emitting diodes simultaneously.
Electrochemical Properties of Multi‐Morphology Polypyrrole Electrode Materials Depended on Template Agents
Authors: Ren Huifang , Sun Ran , Jin Yu , Xu Muhuan , Pei Yifei , Wang Qiyang , Yan Manqing 
Published: October 2023

AbstractWith different template agents (blank, macromolecule polyvinyl alcohol PVA and micromolecule cetyltrimethylammonium bromide CTAB), nanoparticle‐like polypyrrole (PPyNP), nanosphere‐like polypyrrole (PPyNS) and nanowire‐like polypyrrole (PPyNW) were synthesized respectively by in‐situ polymerization. Interestingly, the diameter of PPyNS was about 108–160 nm by adjusting the mass of PVA, while the width range of PPyNW was about 63–87 nm by regulating the mass of CTAB. Also, the electrochemical properties of the as‐obtained PPy with rich morphologies were investigated in aqueous electrolytes of different ionic and pH. The results show the electrochemical behaviors largely depend on the morphology of PPy, ionic and pH of the electrolyte. The specific capacitance of PPyNW fabricated with CTAB template delivers a maximum capacitance of 307 F g−1 at 0.5 A g−1 in H2SO4 electrolyte. Thus, the electrochemical behaviors of multi‐morphology PPy in different electrolytes provide a strong reference and good selection for supercapacitor electrode materials.
Fabrication, Characterization and In Vitro Cell Cytotoxicity of ZnO Nanoparticles on MDA‐MB 231 Breast Cancer Cell Line
Authors: Kumar Janakiraman Ashok , Yin Wong Zi , Cheng Zenli , Khanna Kushagra , Begum M. Yasmin , Djearamane Sinouvassane , Bhupathyraaj Mullaicharam , Shing Wong Ling , Kumar Abhishek , Moideen Muthu Mohamed Jamal 
Published: October 2023

AbstractThe intention of this study was to prepare zinc oxide nanoparticles (ZnO‐NPs) via bottom‐up approach and evaluate their physiochemical, antimicrobial and anticancer properties. ZnO‐NPs were first prepared by the direct precipitation method with zinc sulphate heptahydrate, followed by characterization tests using sophisticated analytical and imaging instruments. Upon characterization, ZnO‐NPs were studied for their antimicrobial activities against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa as well as their anticancer activity against breast cancer cell line (MDA‐MB 231). The ZnO‐NPs possessed a mean particle diameter of 225.2 nm and a zeta potential of −15.8 mV. A sharp absorption peak of ZnO was recorded at 354 nm via UV‐Visible spectroscopy. Hexagonal wurtzite shape of ZnO‐NPs has been observed and confirmed by Scanning Electron Microscopy (SEM) and X‐Ray diffraction (XRD). ZnO‐NPs exhibited excellent antimicrobial activity against the Gram‐positive bacteria, Staphylococcus aureus. In an in vitro cell cytotoxicity study, ZnO‐NPs showed a dose‐dependent relationship against MDA‐MB 231 breast cancer cells. It was observed that as the concentration of ZnO‐NPs increased (0.25 μg to 35 μg), there was a sharp reduction in the proliferation rate of the cancer cell line. Overall, our study reported successful synthesis of ZnO‐NPs, which can be efficient antibacterial and anticancer agents.
Functionalized ZIF‐8 with Aminopropyltrimethoxysilane as Montelukast Sodium Carrier for Medical Application
Authors: Kani Seyedeh Narges Mousavi , Samadi‐Maybodi Abdolraouf , Najafzadehvarzi Hossein 
Published: October 2023

AbstractMontelukast sodium (MS) as an anti‐inflammatory agent in asthma requires a drug delivery system to sustain release at specific doses. ZIF‐8 commonly used in drug delivery systems due to its low cytotoxicity and biodegradability was functionalized with 3‐aminopropyltrimethoxysilane (APTES) as a carrier (ZIF‐8@APTES) for MS. The particles were characterized with Field emission scanning electron microscopy (FE‐SEM), Fourier transform infrared (FTIR), X‐ray diffraction (XRD), Brunauer‐Emmett‐Teller (BET) method, and thermogravimetric analysis (TGA). Furthermore, the biocompatibility of ZIF‐8@APTES‐MS on a normal murine cell line (L929) and its antioxidant activity were investigated. The results showed that MS was gradually released from ZIF‐8@APTES‐MS in phosphate buffer solution (pH 7.4) over 6 hours. ZIF‐8@APTES and ZIF‐8@APTES‐MS also had good biocompatibility properties, and significantly (P≤0.05) enhanced total antioxidant activity at high doses (32 μg/mL). In conclusion ZIF‐8@APTES‐MS can be a promising drug delivery system for MS.
Energy‐aware resource management in fog computing for IoT applications: A review, taxonomy, and future directions
Authors: Hashemi Sayed Mohsen , Sahafi Amir , Rahmani Amir Masoud , Bohlouli Mahdi 
Published: October 2023

AbstractThe energy demand for Internet of Things (IoT) applications is increasing with a rise in IoT devices. Rising costs and energy demands can cause serious problems. Fog computing (FC) has recently emerged as a model for location‐aware tasks, data processing, fast computing, and energy consumption reduction. The Fog computing model assists cloud computing in fast processing at the network's edge, which also exerts a vital role in cloud computing. Due to the fast computing in fog servers, different quality of service (QoS) approaches have been proposed in various sections of the fog system, and several quality factors have been considered in this regard. Despite the significance of QoS in Fog computing, no extensive study has focused on QoS and energy consumption methods in this area. Therefore, this article investigates previous research on the use and guarantee of Fog computing. This article reviews six general approaches that discuss the published articles between 2015 and late May 2023. The focal point of this paper is evaluating Fog computing and the energy consumption strategy. This article further shows the advantages, disadvantages, tools, types of evaluation, and quality factors according to the selected approaches. Based on the reviewed studies, some open issues and challenges in Fog computing energy consumption management are suggested for further study.
Estimating the genetic diversity and potential influence of habitat segregation in Channel Catfish
Authors: Janzen Francesco H. , Blouin-Demers Gabriel 
Published: October 2023

Abstract

Objective
Individual habitat preference can reduce intraspecific competition for resources and may differ between age groups, sexes, and adult phenotypes. The Channel Catfish Ictalurus punctatus is a widespread species occurring in diverse freshwater habitats. This species displays breeding philopatry, returning to nesting sites occupied in previous years. Larger Channel Catfish tend to nest in the main channels of large rivers, whereas smaller fish tend to prefer smaller tributaries. The purpose of our study was to determine whether this habitat segregation potentially associated with habitat preference affects the genetic structure of a population. We hypothesized that spatial segregation of breeding sites in the Ottawa River and its smaller tributaries at Lac des Chats reduced gene flow within the population, resulting in genetically differentiated demes associated with lacustrine-like and fluvial habitats.

Methods
Microsatellite allelic data was collected from 162 Channel Catfish.

Result
We found little genetic variation between the Ottawa, Mississippi, and Madawaska rivers. Furthermore, our analyses suggested that the sampled specimens comprised one panmictic population. Fish from one site in the Ottawa River, however, were significantly differentiated from fish from a nearby site also in the Ottawa River as well as from fish from the Mississippi River tributary.

Conclusion
Given that fish from sites further up the Ottawa River were not differentiated from fish from these sites, it is unlikely that geography can account for the differences observed; rather, assortative mating may explain the differentiation. We propose that panmixia within the population is caused by ontogenetic changes in habitat selection, straying individuals, or sex-biased dispersal and philopatry.