bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐Inflammatory and Antioxidant Effects of Rosmarinic Acid Trimetallic (Cu0.5Zn0.5Fe2O4) Nanoparticles
Authors: Imraish Amer , Zihlif Malek , Abu Thiab Tuqa , Al‐Awaida Wajdy , Al‐Ameer Hamzeh J. , Abu‐Irmaileh Basha'er , Al‐Hunaiti Afnan 
Published: January 2024

AbstractNewly, green metallic‐nanoparticles (NPs) have received scientists’ interest due to their wide variable medicinal applications owned to their economical synthesis and biologically compatible nature. In this study, we used rosmarinic acid (RosA) to prepare Cu0.5Zn0.5FeO4 NPs and later encapsulated them using PEG polymer. Characterization of NPs was done using the XRD method and SEM imaging. Further, we explored the encapsulated NPs for anti‐inflammatory properties by downregulating the expression of pro‐inflammatory cytokines mRNA in LPS‐stimulated Raw 264.7 cells. Besides, employing DPPH, NO and ABTS radical scavenging assays to examine the antioxidant activity of the synthesized Cu0.5Zn0.5FeO4 NPs. Cu0.5Zn0.5FeO4 NPs revealed moderate antioxidant activity by scavenging DPPH and nitric oxide. We demonstrated that the NPs showed high potential anti‐inflammatory activity by suppressing the mRNA and protein levels of pro‐inflammatory cytokines in a dose‐dependent manner, in LPS‐induced Raw 264.7 cells. To our best knowledge, this is the first report where RosA was found to be a suitable phyto source for the green synthesis of Cu0.5Zn0.5FeO4 NPs and their in vitro anti‐inflammatory and antioxidant effects. Taken together, our findings suggest that the RosA is a green resource for the eco‐friendly synthesis of Cu0.5Zn0.5FeO4/PEG NPs, which further can be employed as a novel anti‐inflammatory therapeutic agent.
Salivary proteomic profile of response to different resistance training protocols: A case report
Authors: Santos Karina Oliveira , Filho Dalton Muller Pessôa , Ventura Talita Mendes Oliveira , Thomassian Larissa Tercilia Grizzo , Macedo Anderson Geremias , Buzalaf Marília Afonso Rabelo , Braga Aline Silva , Faria Murilo Henrique , Magalhães Ana Carolina 
Published: January 2024

AbstractResistance training (RT) with blood flow restriction (BFR) or high intensity (HI) are effective to increase muscle mass. To understand this effect, techniques known as “omics” are used to identify possible biomarkers. This study analyzed the salivary proteomic profile of healthy individuals trained before and after two RT protocols both designed with eight exercises for upper‐ and lower‐limbs, one performed at low percentage of one‐maximum repetition (%1RM) with BFR technique, and other at high %1RM (HI) without BRF technique. Four healthy males between 18 and 28 years participated in the study. Stimulated saliva was collected before (BBFR/BHI) and immediately after (ABFR/AHI) the two RT protocols. All protein‐related processing was performed using label‐free proteomic. The difference in expression between groups was expressed as p < .05 for downregulated proteins and 1‐p > .95 for upregulated proteins. There was difference in salivary flow between ABFR and BBFR (p = .005). For HI, 87 proteins were found after the practice and 119 before. Three hemoglobin isoforms were increased in AHI compared with BHI. In the BFR comparison, 105 proteins were identified after (ABFR) and 70 before (BBFR). Among those increased ABFR, we highlight five hemoglobin isoforms and Deleted in malignant brain tumors 1 protein. Between ABFR and AHI, 17 isoforms of histones, Transaldolase, Transketolase, Glyceraldehyde‐3‐phosphate dehydrogenase, and Antileukoproteinase were decreased ABFR. For HI, there was an increase in proteins related to oxidative stress and metabolism of the musculoskeletal system, compared with BFR. HI seems to induce higher anabolic signaling to muscle mass increase and antiatherosclerotic effects.
Identification of Ligands for Ion Channels: TRPM2
Authors: Gu Yushu , Liu Miaomiao , Ma Linlin , Quinn Ronald J. 
Published: January 2024

AbstractTransient receptor potential melastatin 2 (TRPM2) is a calcium‐permeable, nonselective cation channel with a widespread distribution throughout the body. It is involved in many pathological and physiological processes, making it a potential therapeutic target for various diseases, including Alzheimer's disease, Parkinson's disease, and cancers. New analytical techniques are beneficial for gaining a deeper understanding of its involvement in disease pathogenesis and for advancing the drug discovery for TRPM2‐related diseases. In this work, we present the application of collision‐induced affinity selection mass spectrometry (CIAS‐MS) for the direct identification of ligands binding to TRPM2. CIAS‐MS circumvents the need for high mass detection typically associated with mass spectrometry of large membrane proteins. Instead, it focuses on the detection of small molecules dissociated from the ligand‐protein‐detergent complexes. This affinity selection approach consolidates all affinity selection steps within the mass spectrometer, resulting in a streamlined process. We showed the direct identification of a known TRPM2 ligand dissociated from the protein‐ligand complex. We demonstrated that CIAS‐MS can identify binding ligands from complex mixtures of compounds and screened a compound library against TRPM2. We investigated the impact of voltage increments and ligand concentrations on the dissociation behavior of the binding ligand, revealing a dose‐dependent relationship.
Rational Design of S‐scheme Heterojunction Based‐Polymeric Carbon Nitride for Enhanced Photocatalytic Oxygen Reduction Reaction Performance
Authors: Zhang Yunxiao , Cao Qingxiang , Chen Xia , Li Wei , Chen Yanwu , Chen Jiazhi 
Published: January 2024

AbstractS‐scheme heterojunction has emerging as a new star in the field of photocatalysis, attributing to its superior separation of photogenerated charge carriers and strong redox abilities. The general designing criteria and several types of S‐scheme heterojunction were provided. Advanced characterization techniques, including Kelvin probe force microscopy, electron paramagnetic resonance spectroscopy, and in‐situ irradiated X‐ray photoelectron spectroscopy, were presented for disclosing the transfer mechanism in S‐scheme heterojunctions. The recent innovations in the application of photocatalytic oxygen reduction reaction in S‐scheme heterojunction based polymeric carbon nitride photocatalyst were discussed. To conclude, this concept highlights the role of S‐scheme heterojunction in photocatalysis and gives future perspectives on their further applications.
Quaternary layered Cr‐doped modified NCMFe cathode material for Lithium‐Ion Batteries
Authors: Zhang Ming‐Lv , He Jie‐Long , Wu Hua‐Cheng , Tang Zhen‐Yuan , Luo Qian , Wu Jia‐Ni , Li Jun 
Published: January 2024

AbstractA series of cathode materials, Li[Ni0.6Co0.12Mn0.2Fe0.08]1‐xCrxO2 (x=0, 0.02, 0.04, 0.06), are synthesized via the co‐precipitation method. Structural characterization shows that Cr3+ ions are successfully incorporated into the material structure and evenly dispersed on the surface of crystal particles with other metal elements. The Cr‐doped material shows a well‐defined hexagonal layered structure with less cation mixing, and the increase in interionic and interlayer distances is beneficial for the transport of lithium ions. Compared to the pure NCMFe phase, the cyclic and rate performances of the Cr‐doped quaternary materials have been significantly improved. Among them, the 4Cr material exhibits the best electrochemical performance. The capacity retention rate after 50 charge‐discharge cycles at 0.1 C was increased from 74.83 % to 87.32 %. The rate performance has also increased from 87.6 % to 92.69 %. The Cr‐doped cathode can reduce the charge transfer resistance and enhance the stability of the layered structure, which results in outstanding electrochemical performance of the Cr‐doped cathode. CV and EIS tests were conducted on materials with various Cr doping levels, further confirming that Cr doping can reduce the degree of polarization in electrode materials, enhance charge and discharge reversibility, and reduce the charge transfer resistance of materials.
Adaptive deep fusion neural network based soft sensor for industrial process
Authors: Guo Xiaoping , Chong Jialin , Li Yuan 
Published: January 2024

AbstractDeep neural networks have become an important tool for soft sensor modeling. However, common deep autoencoder networks are limited to mining the effective information of each input layer during hierarchical training, ignoring the loss of effective information in the original input data and accumulating it layer‐by‐layer, resulting in incomplete feature representation of the original input. At the same time, there is a lack of mining for temporal correlation between process samples and an adaptive mechanism to strengthen temporal related features, resulting in insufficient process information mining. In addition, deep neural networks generally have overfitting problems. To this end, an adaptive deep fusion neural network (ADFNN) method is proposed. This method reconstructs the original input data at each layer of the feature extraction network. By using the reconstructed original input error in pre‐training loss, it reduces the loss of effective information from the original input. Simultaneously, incorporating sliding windows and self‐attention mechanisms to select and calculate the contribution of historical samples to the current sample, integrating temporal related information, and overcoming dependence on high‐dimensional local features by minimizing Kullback‐Leibier (KL) divergence penalty terms. Finally, the temporal features are adaptively weighted and connected to a fully connected network to achieve quality prediction. Simulation experiments were conducted in cases of debutanizer and industrial polyethylene production to verify the effectiveness of the proposed method. The experimental results show that compared to the stacked autoencoder (SAE), target dependent stacked autoencoder (TSAE), and stacked isomorphic autoencoder (SIAE) models, the proposed method ADFNN has improved prediction accuracy by 2.4%, 1.7%, and 0.5% in the case of a debutanizer, respectively. In the industrial polyethylene production case, it has increased by 3.6%, 3.3%, and 1.8%, respectively.
Exploring the role of information and communication technologies in allergic rhinitis in specialist centers: Patient perspectives on usefulness, value, and impact on healthcare
Authors: Cherrez‐Ojeda Ivan , Bousquet Jean , Sarfraz Zouina , Sarfraz Azza , Rodriguez Gonzales Monica , Bedbrook Anna , Rosario Nelson , Zepeda‐Ortega Benjamin , Guidos Guillermo , Alcivar Molina Ulbio , Felix Miguel , Vanegas Emanuel , Robles‐Velasco Karla , Zimmermann Luc J. , Gavilanes Antonio W. D. 
Published: January 2024

AbstractIntroductionInformation and communication technologies (ICTs) improve patient‐centered care and are routinely used in Allergic Rhinitis (AR), but patients' preferences and attitudes are unexplored. This study examines AR‐related information preferences and ICT use by AR patients.MethodsA survey‐based cross‐sectional study was carried out in Ecuador from July to September 2019 in seven centers of reference for allergic disease. Participants were 18 years or older, diagnosed with AR and had access to ICT and the Internet. Descriptive and binomial logistic regressions were performed. A value of less than 0.05 was considered statistically significant.Results217 patients were included. 47% (n = 102) used ICTs to learn about AR, of which 38.2% (n = 83) found it useful. Most of participants (75%, n = 164) did not think that ICTs reduce their need to see a doctor. Individuals with poorer quality of life were more likely to utilize ICTs to contact their doctor (OR 1.27, 95% CI 1.04–1.55), and more likely to be interested in AR‐related content (OR 1.23, 95% CI 1.00–1.52). Patients with long‐term AR or other allergies were less likely to use ICTs (OR 0.92 and OR 0.40 respectively). Higher education and lower quality of life may increase AR apps adoption (OR 4.82, 95% CI 1.11–21.00). Academic preparation five‐fold increased ICT use for health provider communication (OR 5.29, 95% CI 1.18–23.72). Mild‐persistent AR enhanced the probabilities of using ICTs to share experiences and communicate with other patients (OR 12.59, 95% CI 1.32–120.35).ConclusionsOur study emphasizes the importance of tailoring digital resources to patient needs by considering factors such as quality of life, education, and specific subgroups within the AR patient population. Additionally, the findings suggest that while ICTs can play a valuable role in patient education and support, they should complement, rather than replace, traditional medical care for many AR patients.
A Multicomponent Mannich Reaction Catalyzed by Hydrolases Immobilized on Titanate Nanotubes
Authors: Bessoni Kosctiuk Juliane , Ribeiro Neto Matheus Enrique , Alcoforado Pereira Gabriela , Krieger Nadia , Zambelli Mezalira Daniela , Pilissão Cristiane 
Published: January 2024

AbstractThis study presents an innovative method for synthesizing β‐amino carbonylated compounds, specifically 2‐[phenyl(phenylamino)methyl] cyclohexanone, achieving high conversions and diastereomeric ratios. Using trypsin or α‐chymotrypsin in both free and immobilized forms on titanate nanotubes (NtsTi), synthesized through alkaline hydrothermal methods, successful immobilization yields were attained. Notably, α‐chymotrypsin, when free, displayed a diastereoselective synthesis of the anti‐isomer with 97 % conversion and 16 : 84 (syn : anti) diastereomeric ratio, which slightly decreased upon immobilization on NtsTi. Trypsin, in its free form, exhibited diastereoselective recognition of the syn‐isomer, while immobilization on NtsTi (trypsin/NtsTi) led to an inversion of diastereomeric ratio. Both trypsin/NtsTi and α‐chymotrypsin/NtsTi demonstrated significant catalytic efficiency over five cycles. In conclusion, NtsTi serves as an effective support for trypsin and α‐chymotrypsin immobilization, presenting promising prospects for diastereoselective synthesis and potential industrial applications. Furthermore, it offers promising prospects for the diastereoselective synthesis of 2‐[phenyl(phenylamino)methyl] cyclohexanone through multicomponent Mannich reaction and future industrial application.
Patient perspectives on psychological interventions provided in adult psychiatric inpatient wards: A thematic synthesis
Authors: Carr Lydia , Awenat Yvonne , Ray Sinéad , Tai Sara 
Published: January 2024

AbstractObjectivesPsychological intervention is an important part of psychiatric inpatient treatment for people experiencing severe problems affecting their mental health. Unfortunately, many service users accessing acute inpatient services are not being offered psychological interventions. Recent research has focussed on effectiveness, facilitators and barriers to providing psychological interventions in this setting. This review aimed to provide a qualitative synthesis of service user perspectives regarding psychological interventions provided on inpatient wards, to understand what is helpful and unhelpful about current provision.MethodA systematic literature search of four databases was conducted to identify published qualitative literature regarding service user perspectives of NICE‐recommended psychological interventions provided on adult acute mental health inpatient wards. Study quality was assessed using the Critical Appraisal Skills Programme tool. Data was analysed and synthesised using thematic analysis.ResultsThe search was completed in May 2023. Seventeen studies were included in the review and encapsulated feedback from at least 192 service users. All studies were rated as high or moderate on the quality appraisal tool. Three superordinate themes were identified: ‘Connecting with Others’, ‘Psychological Processes’ and ‘Engaging with the Intervention’. Participants valued supportive relationships with peers and therapists and felt empowered to achieve change through expression, focussing on difficulties and gaining new perspectives. Participants wanted more support to maintain benefits and sometimes struggled to engage with group therapy due to difficult peer dynamics.ConclusionsThe results give a detailed synthesis of some of the important factors, from service users' perspectives, for accessing psychological interventions. Recommendations for clinical practice and future research are provided.
Green fintech: Developing a research agenda
Authors: Puschmann Thomas , Khmarskyi Valentyn 
Published: January 2024

AbstractDigitalization and sustainability have been the core drivers of transformation of the financial industry in recent years. In this context, green fintech plays a major role, which, however, is still an unexplored field in business, information systems and finance research. This paper conducts a systematic literature analysis and develops a research agenda based on a framework, which is derived from clustering 74 academic research papers. The framework consists of the four clusters strategy, organization, technology, and potentials along nine dimensions. The research agenda reveals that green fintech is still a very premature field of research. The analysis shows that areas like customer‐ and government‐related services, insurance‐oriented approaches and SDGs which focus on life on land and life below water are still rare and that most of the approaches focus on blockchain technology, while other financial technologies like artificial intelligence are still underrepresented.
Development and evaluation of multi‐functionalized sialic acid conjugated asiatic acid nanoconstruct to mitigate cognitive deficits in Alzheimer's disease
Authors: Halder Tripti , Saha Bijit , Dhas Namdev , Acharya Sanjeev , Acharya Niyati 
Published: January 2024

AbstractSialic acid (SA) serves a critical role in neuronal repair and cognitive functions. SA is a nine‐carbon carboxylated sugar with a glycoconjugate cap that acts as a ligand and surface decoration with SA facilitates delivery to the target site. The present research aimed to develop SA surface modified AA nanostructured lipid carrier (NLCs) with carbodiimide conjugation method. Sterylamine, poloxamer 188 and tween 80 were used as surfactants and several characterization studies including, differential scanning calorimetry, fourier transform infrared spectroscopy and x‐ray photon spectroscopy were analyzed. Further, in vitro, neuroprotective efficiency was evaluated in SH‐SY5Y cells and hCMEC/D3 cells and found significant potential effects with the treatments of developed NLCs. Pharmacodynamics studies were also assessed in beta‐amyloid‐injected rats following quantification of Alzheimer's disease (AD) hallmarks like, Aβ(1–42), tau‐protein, glycogen synthase kinase‐3β levels, interleukin‐6 and tumor necrosis factor‐α for neuroinflammatory responses. Characterization studies revealed the conjugation on developed NLCs. The in vitro and in vivo results showed significant effects of SA decorated NLCs in reversing the damage by toxicant which was further characterized by the levels of neurotransmitters like acetylcholinesterase, butyrylcholinesterase. The results revealed significant (p < .05) refurbishment of cholinergic functions after 28 days of treatment of developed NLCs. These preclinical findings support the use of SA as a ligand to deliver the AA at targeted site as well as to mitigate the cognitive deficits in AD.
A meta‐analysis of the relationship between glycaemic variability and the mortality of patients with heart failure
Authors: Fu Xiaoxiao , Wei Yang , Fang Jun 
Published: January 2024

AbstractRecent findings indicate that fluctuations in blood glucose could potentially increase the risk of unfavourable outcomes in individuals with cardiovascular conditions. The objective of the research was to assess the correlation between glycaemic variability (GV) and the mortality of patients with heart failure (HF) through a comprehensive review and meta‐analysis. Longitudinal follow‐up studies comparing the mortality risk between HF patients with higher and lower GV were identified by searching Medline, Embase, Web of Science, and Cochrane Library databases. The results were combined using a random‐effects model that accounted for the potential variability. The meta‐analysis included nine cohort studies involving 76 843 patients diagnosed with HF, out of which 35 853 patients died within a follow‐up period of up to 86 months. The combined findings indicated that a significant increase in GV was linked to an elevated risk of mortality in patients with HF during the follow‐up period (RR 2.18, 95% CI 1.61 to 2.96, P < 0.001, I2 = 83%). The relationship between GV and mortality in HF patients was not significantly influenced by the patients' diabetic status (diabetic or non‐diabetic), type of GV (acute or long‐term GV), study design (prospective or retrospective), country of the study (Asian or non‐Asian), follow‐up durations, or the scores of study quality (P‐values for subgroup differences all >0.05). A high GV could be a risk factor of mortality of patients with HF.
Novel electrocardiographic criteria may render possible the more accurate recognition of cardiac amyloidosis
Authors: Vereckei András , Katona Gábor , Szénási Gábor , Vidács László Dániel , Földeák Dóra , Takács Hedvig , Nagy Viktória , Sepp Róbert 
Published: January 2024

AbstractAimsThe early diagnosis of cardiac amyloidosis (CA) is paramount, since there are effective therapies that improve patient survival. The diagnostic accuracy of classical electrocardiographic (ECG) signs, such as low voltage, pseudoinfarct pattern, and conduction disturbances in the diagnosis of CA, is inferior to that of the echocardiographic myocardial deformation criteria; therefore, our aim was to find more accurate novel ECG criteria for this purpose.MethodsWe tested the diagnostic value of five novel ECG criteria, two of them devised by us, in 34 patients with confirmed CA (20 transthyretin amyloidosis and 14 AL amyloidosis) and 45 control patients with left ventricular hypertrophy on echocardiography due to hypertension, valvular aortic stenosis and hypertrophic cardiomyopathy. The following novel ECG criteria, that suggested CA, were tested: QRS amplitude in lead I < 0.55 mV (I < 0.55); QRS amplitude in lead aVR < 0.5 mV (aVR < 0.5); average QRS amplitude of leads I + aVR < 0.575 mV [(I + aVR) < 0.575]; average QRS amplitude of leads I + aVR/average QRS amplitude of leads V1–4 < 0.375 [(I + aVR)/(V1–4) < 0.375]; average QRS amplitude of leads I + aVR/longest intrinsicoid deflection in leads I,aVL,V1–6 < 0.0115 [(I + aVR)/I,aVL,V1–6ID < 0.0115].ResultsThe I < 0.55, aVR < 0.5, (I + aVR) < 0.575, (I + aVR)/(V1–4) < 0.375, (I + aVR)/I,aVL,V1–6ID < 0.0115 test accuracy (TA) were 81%, 84.8%, 82.3%, 84.8%, and 83.3%, respectively; the sensitivity (SE): 76.5%, 82.4%, 85.3%, 82.4%, and 76.9%; specificity (SP): 84.4%, 86.7%, 80%, 86.7%, and 87.5%; positive predictive values (PPV): 78.8%, 82.4%, 76.3%, 82.4%, and 80%; negative predictive values (NPV): 82.6%, 86.7%, 87.8%, 86.7%, and 85.4%; area under curve (AUC) values: 0.8922, 0.8794, 09016, 0.8824, and 0.8462 were respectively. These parameters of the novel ECG criteria were at least as good as those reported by other authors in the literature of the qualitative (TA: 67%, SE: 80%, SP: 34%, PPV: 75%, NPV: 42%, AUC: 0.57) and quantitative apical sparing (TA: 64–80%, SE: 66–81.3%, SP: 55–78.3%, PPV: 33–83.9%, NPV: 41–75%, AUC: 0.62–0.68) and left ventricular ejection fraction/global longitudinal strain >4.1 (TA: 77%, SE: 93%, SP: 38%, PPV: 79%, NPV: 69%, AUC: 0.65) echocardiographic criteria. Among the classical criteria, the low voltage in limb leads criterion was present most frequently (in 73.5%) in patients with CA, with slightly worse diagnostic value than the novel ECG criteria (TA: 78.5%, SE: 73.5%, SP: 82.2%, PPV: 75.8%, NPV: 80.4%).ConclusionsThe novel ECG criteria [mostly the aVR < 0.5, (I + aVR)/(V1–4) < 0.375] seem at least as reliable in the diagnosis of CA as the best echocardiographic myocardial deformation criteria and might be used either together with the echocardiographic criteria or as stand‐alone criteria to diagnose CA in the future.