bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary liver‐type fatty acid binding protein is a biomarker reflecting renal damage and the ameliorative effect of drugs at an early stage of histone‐induced acute kidney injury
Authors: Ohata Keiichi , Sugaya Takeshi , Nguyen Hanh Nhung , Arai Karin , Hatanaka Yuri , Uno Kinuko , Tohma Marika , Uechi Teppei , Sekiguchi Keita , Oikawa Tsuyoshi , Nagabukuro Hiroshi , Kuniyeda Kanako , Kamijo‐Ikemori Atsuko , Suzuki‐Kemuriyama Noriko , Nakae Dai , Noiri Eisei , Miyajima Katsuhiro 
Published: November 2023

AbstractAimCirculated histones play a crucial role in the pathogenesis of infectious diseases and severe trauma, and it is one of the potential molecular targets for therapeutics. Recently, we reported that histone is one of the causative agents for urinary L‐FABP increase. However, the mechanism is still unclear, especially in severe cases. We further investigated the mechanism of urinary L‐FABP increase using a more severe mouse model with histone‐induced kidney injury. This study also aims to evaluate the therapeutic responsiveness of urinary L‐FABP as a preliminary study.MethodsHuman L‐FABP chromosomal transgenic mice were administrated 30 mg/kg histone from a tail vein with a single dose. We also performed a comparative study in LPS administration model. For the evaluation of the therapeutic responsiveness of urinary L‐FABP, we used heparin and rolipram.ResultsThe histological change with cast formation as a characteristic of the models was observed in proximal tubules. Urinary L‐FABP levels were significantly elevated and these levels tended to be higher in those with more cast formation. Heparin and rolipram had the ameliorative effect of the cast formation induced by histone and urinary L‐FABP levels significantly decreased.ConclusionHistone is one of the causative agents for the increase of urinary L‐FABP at an early stage of AKI. In addition, it suggested that urinary L‐FABP may be useful as a subclinical AKI marker reflecting kidney damage induced by histone. Furthermore, urinary L‐FABP reflected the degree of the damage after the administration of therapeutic agents such as heparin and PDE4 inhibitor.
Warming influences carbon and nitrogen assimilation between a widespread Ericaceous shrub and root‐associated fungi
Authors: Hupperts Stefan F. , Islam Kazi Samiul , Gundale Michael J. , Kardol Paul , Sundqvist Maja K. 
Published: November 2023

Summary

High‐latitude ecosystems are warming faster than other biomes and are often dominated by a ground layer of Ericaceous shrubs, which can respond positively to warming. The carbon‐for‐nitrogen (C‐for‐N) exchange between Ericaceous shrubs and root‐associated fungi may underlie shrub responses to warming, but has been understudied.

In a glasshouse setting, we examined the effects of warming on the C‐for‐N exchange between the Ericaceous shrub Empetrum nigrum ssp. hermaphroditum and its root‐associated fungi. We applied different 13C and 15N isotope labels, including a simple organic N form (glycine) and a complex organic N form (moss litter) and quantified their assimilation into soil, plant biomass, and root fungal biomass pools.

We found that warming lowered the amount of 13C partitioned to root‐associated fungi per unit of glycine 15N assimilated by E. nigrum, but only in the short term. By contrast, warming increased the amount of 13C partitioned to root‐associated fungi per unit of moss 15N assimilated by E. nigrum.

Our study suggests that climate warming affects the short‐term exchange of C and N between a widespread Ericaceous shrub and root‐associated fungi. Furthermore, while most isotope tracing studies use labile N sources, we demonstrate that a ubiquitous recalcitrant N source may produce contrasting results.
Diet, gym, supplements, or maybe it is all in your mind? A systematic review and meta‐analysis of studies on placebo and nocebo effects in weight loss in adults
Authors: Żegleń Magdalena , Kryst Łukasz , Bąbel Przemysław 
Published: November 2023

SummaryIntroductionThere is evidence that placebo and nocebo effects are significant for many conditions, but their impact on weight loss has not yet been well described.Material and methodsA systematic review of studies indexed on PubMed, Cochrane, PsycINFO, PsycARTICLES, TripDatabase, and Embase was carried out. Studies (1) with at least two study groups — placebo and a corresponding control group; (2) published in English; and (3) focusing on adults participating in weight loss programs or on placebo/nocebo effects in weight loss were included. Synthesis and meta‐analysis of the results of studies with comparable research plans were performed.ResultsSome preliminary trends suggesting placebo and nocebo effects in weight loss were found. Placebo effects manifested in trends towards a slightly greater reduction of Body Mass Index (BMI) and body fat ratio in the placebo compared with the control groups. On the other hand, in one study, it was found that the expectancy effects of taking oral weight‐loss agents might be disadvantageous (i.e., because they elicit a nocebo effect on weight loss).ConclusionThe findings suggest a possibility that the nocebo effect may occur when an intervention has a medical context. In contrast, the placebo effect can be observed in cases where the intervention is of a different nature. However, considering the low number of studies analyzing the use of placebos in weight loss, new primary research is needed.
Peripheral refraction under different levels of illuminance
Authors: Marcellán Vidosa María Concepción , Remón Laura , Ávila Francisco J. 
Published: November 2023

AbstractPeripheral refraction is believed to be involved in the development of myopia. The aim of this study was to compare the relative peripheral refraction (RPR) at four different levels of illuminance, ranging from photopic conditions to complete darkness, using an open‐field autorefraction method. The RPR was calculated for each eccentricity by subtracting central from peripheral autorefraction measurements. The study included 114 myopic eyes from 114 subjects (mean age of 21.81 ± 1.91 years) and the mean difference in RPR between scotopic and photopic conditions (0 and 300 lux, respectively) was +0.32 D at 30° temporal and +0.37 D at 30° in the nasal visual field (NVF). Statistically significant differences were observed between 0 and 300 lux at 30° in the temporal visual field and at 30° and 20° in the NVF. Our results revealed a significant increase in relative peripheral hyperopia with increasing visual field eccentricity along the horizontal visual field in myopic eyes of young adults. Furthermore, this relative peripheral hyperopia increased as illumination decreased. These findings suggest that an increase in peripheral illuminance may protect against myopic eye growth.
Predictive coding I: Introduction
Authors: Sprevak Mark 
Published: November 2023

AbstractPredictive coding – sometimes also known as ‘predictive processing’, ‘free energy minimisation’, or ‘prediction error minimisation’ – claims to offer a complete, unified theory of cognition that stretches all the way from cellular biology to phenomenology. However, the exact content of the view, and how it might achieve its ambitions, is not clear. This series of articles examines predictive coding and attempts to identify its key commitments and justification. The present article begins by focusing on possible confounds with predictive coding: claims that are often identified with predictive coding, but which are not predictive coding. These include the idea that the brain employs an efficient scheme for encoding its incoming sensory signals; that perceptual experience is shaped by prior beliefs; that cognition involves minimisation of prediction error; that the brain is a probabilistic inference engine; and that the brain learns and employs a generative model of the world. These ideas have garnered widespread support in modern cognitive neuroscience, but it is important not to conflate them with predictive coding.
An explorative multiverse study for extracting differences in P3 latencies between young and old adults
Authors: Sadus Kathrin , Schubert Anna‐Lena , Löffler Christoph , Hagemann Dirk 
Published: November 2023

AbstractIt is well established that P3 latencies increase with age. Investigating these age‐related differences requires numerous methodological decisions, resulting in pipelines of great variation. The aim of the present work was to investigate the effects of different analytical pipelines on the age‐related differences in P3 latencies in real data. Therefore, we conducted an explorative multiverse study and varied the low‐pass filter (4 Hz, 8 Hz, 16 Hz, 32 Hz, and no filter), the latency type (area vs. peak), the level of event‐related potential analysis (single participant vs. jackknifing), and the extraction method (manual vs. automated). Thirty young (18–21 years) and 30 old (50–60 years) participants completed three tasks (Nback task, Switching task, Flanker task), while an EEG was recorded. The results show that different analysis strategies can have a tremendous impact on the detection and magnitude of the age effect, with effect sizes ranging from 0% to 88% explained variance. Likewise, regarding the psychometric properties of P3 latencies, we found that the reliabilities fluctuated between rtt = .20 and 1.00, while the homogeneities ranged from rh = −.12 to .90. Based on predefined criteria, we found that the most effective pipelines relied on a manual extraction based on a single participant's data. For peak latencies, manual extraction performed well for all filters except for 4 Hz, while for area latencies, filters above 8 Hz produced desirable results. Furthermore, our findings add to the evidence that jackknifing combined with peak latencies can lead to inconclusive results.
A systematic review of hair cortisol in healthy adults measured using immunoassays: Methodological considerations and proposed reference values for research
Authors: Igboanugo Somkene , O'Connor Claire , Zitoun Osama A. , Ramezan Reza , Mielke John G. 
Published: November 2023

AbstractHair cortisol concentration (HCC) has shown remarkable promise as a stable, non‐invasive measure of systemic cortisol; however, despite methodological advances, the value that would typically be seen in healthy adults has not been established. Therefore, we sought to review the relevant literature to determine a reference value for HCC in healthy (i.e., non‐clinical) adults. To this end, we conducted a systematic review of the PubMed, Scopus, and CINAHL databases for studies that measured healthy adult HCC using immunoassay methods, given that these are the most widely accessible analytical tools. To be eligible, studies were required to have been published in English, to have provided relevant descriptive statistics (i.e., means and standard deviations), and to have used a healthy adult human sample. We found 17 studies that met our inclusion criteria; the reports involved 1348 participants with a mean age of about 38 years. Since we identified a large amount of between‐study heterogeneity, we completed a random‐effect meta‐regression analysis and found that test kit vendor was the only significant variable of the model. As a result, when using methodologies from traditional finite mixture distributions to determine reference values for mean and elevated HCC in individual healthy adults, we calculated these estimates for each of the major test kit vendors. Future work will need to determine whether our estimated reference values need to be modified, and these efforts will be greatly assisted by studies that account for potential moderating factors, such as age, sex, and ethnicity.
Brains of endurance athletes differ in the association areas but not in the primary areas
Authors: Geisler Maria , de la Cruz Feliberto , Makris Nikos , Billah Tashrif , Zhang Fan , Rathi Yogesh , O'Donnell Lauren J. , Bouix Sylvain , Herbsleb Marco , Bär Karl‐Jürgen , Kikinis Zora , Weiss Thomas 
Published: November 2023

AbstractRegular participation in sports results in a series of physiological adaptations. However, little is known about the brain adaptations to physical activity. Here we aimed to investigate whether young endurance athletes and non‐athletes differ in the gray and white matter of the brain and whether cardiorespiratory fitness (CRF) is associated with these differences. We assessed the CRF, volumes of the gray and white matter of the brain using structural magnetic resonance imaging (sMRI), and brain white matter connections using diffusion magnetic resonance imaging (dMRI) in 20 young male endurance athletes and 21 healthy non‐athletes. While total brain volume was similar in both groups, the white matter volume was larger and the gray matter volume was smaller in the athletes compared to non‐athletes. The reduction of gray matter was located in the association areas of the brain that are specialized in processing of sensory stimuli. In the microstructure analysis, significant group differences were found only in the association tracts, for example, the inferior occipito‐frontal fascicle (IOFF) showing higher fractional anisotropy and lower radial diffusivity, indicating stronger myelination in this tract. Additionally, gray and white matter brain volumes, as well as association tracts correlated with CRF. No changes were observed in other brain areas or tracts. In summary, the brain signature of the endurance athlete is characterized by changes in the integration of sensory and motor information in the association areas.
Enhancing phosphorus bioavailability in lateritic red soil: Combining Bacillus subtilis inoculated microbial organic fertilizer with reduced chemical input
Authors: Duan Yali , Li Dong , Li Zhidong , Luo Jialiang , Sun Xiaoyan , Zhang Haixiang , Li Yangwenzheng , Liu Fan , Zhang Kailu , Hu Yueming , Zhang Xin , Zhu Zhiqiang 
Published: November 2023

AbstractOptimal phosphorus (P) levels in lateritic soils are key for sustainable crop production. However, the effect of various fertilizers on soil phosphorus pools, crop phosphorus uptake and crop yields remains unclear. This study investigated the effect of different fertilizer application strategies on plant growth and soil P fractions and determined the contribution of biotic and abiotic factors to insoluble P release. We found that resin‐P, NaHCO3‐P and NaOH‐P represented the primary active P pools in the lateritic soil, contributing 59.8% of the total P in conventional fertilizer application (CF), with Fe/Al‐bound P (NaOH‐P) being 42.1% of the active P pool. Combining Nangbowang (NBW), a microbial organic fertilizer inoculated with Bacillus subtilis (≥2 × 107 million CFU g−1), with reduced chemical fertilizer (NBW + CR) increased soil P availability and promoted the release of Fe/Al‐bound P and residual‐P, decreasing the Fe/Al‐bound P to 21.7%. Soil biological factors mainly influenced the P transformation process. With the consumption of soil active P, NBW bio‐organic fertilizer enhanced the niche filtration of P‐solubilizing bacterial communities (Gemmatimonadetes, Sphingomonas and Halomonas), altered the soil functional microbial community structure and promoted P form conversion. The NBW + CR treatment also enhanced nitrogen and P nutrient uptake by pepper plants (Capsicum annuum), with increased total P concentrations in pepper fruit and stem, and improved crop yield. NBW increased active P concentrations in the soil and promoted Fe/Al‐P release and transformation by impacting autochthonous microbes involved in the conversion of P chemical species. These results can guide the improvement of P availability and release in lateritic red soils using bio‐organic fertilizer.
Plasmopara viticola effector PvCRN11 induces disease resistance to downy mildew in grapevine
Authors: Fu Qingqing , Yang Jing , Zhang Kangzhuang , Yin Kaixin , Xiang Gaoqing , Yin Xiao , Liu Guotian , Xu Yan 
Published: November 2023

SUMMARYThe downy mildew of grapevine (Vitis vinifera L.) is caused by Plasmopara viticola and is a major production problem in most grape‐growing regions. The vast majority of effectors act as virulence factors and sabotage plant immunity. Here, we describe in detail one of the putative P. viticola Crinkler (CRN) effector genes, PvCRN11, which is highly transcribed during the infection stages in the downy mildew‐susceptible grapevine V. vinifera cv. ‘Pinot Noir’ and V. vinifera cv. ‘Thompson Seedless’. Cell death‐inducing activity analyses reveal that PvCRN11 was able to induce spot cell death in the leaves of Nicotiana benthamiana but did not induce cell death in the leaves of the downy mildew‐resistant V. riparia accession ‘Beaumont’ or of the downy mildew‐susceptible ‘Thompson Seedless’. Unexpectedly, stable expression of PvCRN11 inhibited the colonization of P. viticola in grapevine and Phytophthora capsici in Arabidopsis. Both transgenic grapevine and Arabidopsis constitutively expressing PvCRN11 promoted plant immunity. PvCRN11 is localized in the nucleus and cytoplasm, whereas PvCRN11‐induced plant immunity is nucleus‐independent. The purified protein PvCRN11Opt initiated significant plant immunity extracellularly, leading to enhanced accumulations of reactive oxygen species, activation of MAPK and up‐regulation of the defense‐related genes PR1 and PR2. Furthermore, PvCRN11Opt induces BAK1‐dependent immunity in the apoplast, whereas PvCRN11 overexpression in intracellular induces BAK1‐independent immunity. In conclusion, the PvCRN11 protein triggers resistance against P. viticola in grapevine, suggesting a potential for the use of PvCRN11 in grape production as a protectant against downy mildew.
Analytic ranks of automorphic L$L$‐functions and Landau–Siegel zeros
Authors: Bui Hung M. , Pratt Kyle , Zaharescu Alexandru 
Published: November 2023

AbstractWe relate the study of Landau–Siegel zeros to the ranks of Jacobians of modular curves for large primes . By a conjecture of Brumer–Murty, the rank should be equal to half of the dimension. Equivalently, almost all newforms of weight two and level have analytic rank . We show that either Landau–Siegel zeros do not exist, or that, for wide ranges of , almost all such newforms have analytic rank . In particular, in wide ranges, almost all odd newforms have analytic rank equal to one. Additionally, for a sparse set of primes in a wide range, we show that the rank of is asymptotically equal to the rank predicted by the Brumer–Murty conjecture.
Geodesic deviation equation in generalized hybrid metric-Palatini gravity
Authors: Golsanamlou S. , Atazadeh K. , Mousavi M. 
Published: November 2023

AbstractIn the context of general relativity, the geodesic deviation equation (GDE) relates the Riemann curvature tensor to the relative acceleration of two neighboring geodesics. In this paper, we consider the GDE for the generalized hybrid metric-Palatini gravity and apply it in this model to investigate the structure of time-like, space-like, and null geodesics in the homogeneous and isotropic universe. We propose a particular case $$f(R,{{\mathcal {R}}})=R+{{\mathcal {R}}}$$

f
(
R
,
R
)
=
R
+
R

to study the numerical behavior of the deviation vector $$\eta (z)$$

η
(
z
)

and the observer area–distance $$r_{0}(z)$$

r
0

(
z
)

with respect to redshift z. Also, we consider the GDE in the framework of the scalar–tensor representation of the generalized hybrid metric-Palatini gravity, i.e., $$f(R, {{\mathcal {R}}} )$$

f
(
R
,
R
)

, in which the model can be considered as dynamically equivalent to a gravitational theory with two scalar fields. Finally, we extend our calculations to obtain the modification of the Mattig relation in this model.
$$\gamma $$-Ray detection with CsI(Tl) scintillators of the FARCOS array
Authors: Geraci Elena , Cardella Giuseppe , Maiolino Concettina , Martorana Nunzia S. , Acosta Luis , De Filippo Enrico , Fichera Filippo , Gnoffo Brunilde , Grimaldi Antonio , Guazzoni Chiara , Librizzi Francesco , Noto Francesco , Pagano Angelo , Pagano Emanuele V. , Passaro Giuseppe , Pirrone Sara , Politi Giuseppe , Risitano Fabio , Rizzo Francesca , Russotto Paolo , Saccà Gaspare , Santagati Gianluca , Trimarchi Marina , Zagami Cristina 
Published: November 2023

AbstractThe measurement of the response function of the CsI(Tl) scintillators of the FARCOS array, to standard sources, cosmic rays and environmental background allows the assessment of their performance. Fast–Slow analysis discriminates between $$\gamma $$
γ
-rays and charged particles. The relatively good energy resolution allows the observation of well resolved escape peaks due to the interaction of the 4.44 MeV $$\gamma $$
γ
-ray generated by AmBe source. Furthermore, the small noise enables to discriminate from the background the annihilation 511 keV $$\gamma $$
γ
-rays of the $$^{22}$$

22

Na source. The energy loss of muons generated by cosmic rays has been also measured and the radioactive contaminants as $$^{137}$$

137

Cs, $$^{40}$$

40

K and $$^{208}$$

208

Tl have been identified. The quality of the detectors suggests the possibility to use the array also for the measurement of $$\gamma $$
γ
-ray decay in reactions induced by stable and radioactive beams, once a well-defined reaction channel has been identified. Moreover, a dedicated compact detection module as a portable, high efficiency radiation detector for the control of environmental contamination will be developed.
Factors Associated with Children’s Humane Attitudes toward Animals
Authors: Calderón-Amor Javiera , Palma Camila , Gallo Carmen 
Published: November 2023

Abstract
Various studies have suggested a range of different factors associated with children’s attitudes toward animals; however, in Chile, it is an area that has not been studied. The current study administered the Intermediate Attitude Scale (IAS, which measures attitudes toward the humane treatment of animals) to 286 children in third and fourth grade and analyzed its association with the following variables: type of school, grade, gender, current pet ownership, the recognition accuracy of dog facial expressions, and human-directed empathy. The association between the IAS and potential factors was measured through linear mixed models. Children with higher human-directed empathy scores, fourth-grade children, and children who were more accurate in recognizing the happiness emotion on the dog’s face were associated with more positive attitudes toward the humane treatment of animals. These findings contribute to the growing literature regarding the importance of positive attitudes toward animals and their connection to human-directed empathy.
Misperceptions of the Border: Migration, Race, and Class Today
Authors: Hanieh Adam , Ziadah Rafeef 
Published: November 2023

Abstract
This paper addresses the role of global migration and the nature of national borders within the co-constitution of class and race. We begin with Marx’s critique of the value-form – a critique that rests upon a distinction between the ‘essence’ of social reality and its immediate appearances. The paper elaborates how Marx’s understanding of the emergence of a society based upon generalised commodity production leads to a certain conception of the ‘political state’ and citizenship – and thus borders and national belonging. This reveals the distinctive territorial forms of capitalism vis-à-vis those found in pre-capitalist societies, and moves us away from transhistorical conceptions of borders and the nation-state. In the second half, the paper turns to look at what this conception of borders and migration might mean concretely for how we think about the co-constitution of race and class today. Here the focus is on three crucial aspects of the contemporary world market: (1) the relationship between the cross-border movements of labour and processes of class formation, (2) migration and the determination of the value of labour-power, and (3) coercive and unfree labour.