bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Huntingtin Knockout in Adult Mice Leads to Fatal Neurodegeneration that Spares the Pancreas
Authors: Bragg Robert M. , Mathews Ella W. , Grindeland Andrea , Cantle Jeffrey P. , Howland David , Vogt Tom , Carroll Jeffrey B. 
Published: January 2024

AbstractHuntington’s disease (HD) is a fatal neurogenerative disorder caused by an expanded glutamine-coding CAG tract in the Huntingtin (Htt) gene. HD is believed to primarily arise via a toxic gain of function, and as a result a wide range of Htt-lowering treatments are in clinical trials. The safety of these trials is contingent on the risks imposed by Htt lowering: Htt is widely conserved, ubiquitously expressed and its complete loss causes severe developmental symptoms in mice and humans. Recently, multiple labs have reported on the consequences of widespread inducible Htt loss in mice. One report describes that early induction of global Htt loss causes fatal pancreatitis, but that later onset lowering is benign. Another study did not report fatal pancreatitis but suggested that postnatal Htt loss was associated with widespread progressive phenotypes, including subcortical calcification and neurodegeneration. To better understand the risks posed by widespread inducible Htt loss we established the phenotypes of mice in which we knocked out Htt with two tamoxifen inducible Cre lines, which we have here extensively characterized. In short, we find that widespread loss of Htt at 2 months of age leads to a wide range of phenotypes, including subcortical calcification, but does not result in acute pancreatitis or histological changes in the pancreas. Additionally, we report here for the first time that Htt loss is followed by robust and sustained increases in the levels of neurofilament light chain (NfL), a peripherally accessible biomarker of neuroaxonal stress. These results confirm that complete loss of Htt in mice is associated with pronounced risks, including progressive subcortical calcification and neurodegeneration.
Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy
Authors: Iida Madoka , Sahashi Kentaro , Hirunagi Tomoki , Sakakibara Kenji , Maeda Kentaro , Ogura Yosuke , Iizuka Masaki , Akashi Tomohiro , Hinohara Kunihiko , Katsuno Masahisa 
Published: January 2024

AbstractSpinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by an expanded CAG repeat in theandrogen receptor(AR) gene. To elucidate the cell type-specific temporal gene expression in SBMA, we performed single-nucleus RNA sequencing on the spinal cords of AR-97Q mice. Among all cell types, oligodendrocytes (OLs) had the highest number of differentially expressed genes before disease onset. Analysis of OL clusters suggested that pathways associated with cation channels and synaptic function were activated before disease onset, with increased output from OLs to neurons in AR-97Q mice compared to wild-type mice. These changes in the early stages were abrogated in the advanced stages. An OL cell model of SBMA showed phenotypes similar to those of AR-97Q mice at early stages, such as increased transcriptional changes in synapse organization. Our results indicate that the dysregulation of cell-to-cell communication has a major impact on the early pathology of SBMA and is a potential therapeutic target for SBMA.
Dynamics of heavy quarks in the Fock space
Authors: Serafin Kamil , Gómez-Rocha María , More Jai , Głazek S. D. 
Published: January 2024

This paper concerns a method of describing hadrons that starts with the canonical front form Hamiltonian of QCD. The method is developed in the relatively simple context of QCD with only heavy quarks. We regulate its canonical Hamiltonian by introducing a vanishingly small gluon mass mg. For positive mg, the small-x gluon divergences become ultraviolet and hence they are renormalized in the same way the ultraviolet transverse divergences are. This is done using the renormalization group procedure for effective particles. Up to the second order of expansion of the renormalized Hamiltonian in powers of the quark-gluon coupling constant g, only the quark mass-squared and gluon-exchange divergences require counterterms. In these circumstances, we calculate an effective potential between quarks in heavy quarkonia in an elementary way, replacing all the quarkonium-state components with gluons of mass mg by only one component with just one gluon that is assigned a mass mG, comparable to or exceeding the scale of typical relative momenta of bound quarks. In the limit of mg→0 and large mG two results are obtained. (1) While the color-singlet quarkonium mass eigenvalue stays finite and physically reasonable in that limit, the eigenvalues for single quarks and octet quarkonia are infinite. (2) Besides the coulomb terms, the effective quark-antiquark potential is quadratic as a function of the distance and spherically symmetric for typical separations between quarks but becomes logarithmic and no longer spherically symmetric for large separations. Our conclusion indicates how to systematically improve upon the approximations made in this paper.

Published by the American Physical Society
2024
Industry 4.0 and supply chain sustainability: benchmarking enablers to build reliable supply chain
Authors: Pandey Ajay Kumar , Pratap Saurabh , Dwivedi Ashish , Khan Sharfuddin Ahmed 
Published: January 2024

PurposeThe existing literature reflects that the connection between enablers of Industry 4.0 (I4.0), Supply Chain (SC) sustainability and reliability is understudied. To cover this gap, the purpose of this study is to identify and benchmark the enablers of I4.0 for SC sustainability to build a Reliable Supply Chain (RSC).Design/methodology/approachThis study benchmarks the I4.0 enablers for SC sustainability for building a RSC and analyses them with a multi-method approach. The identified potential enablers are validated empirically. A multi-method approach of Analytical Hierarchy Process (AHP), Decision Making Trial and Evaluation Laboratory (DEMATEL) and Preference Ranking for Organization Method for Enrichment Evaluation (PROMETHEE-II) was used to investigate the influence of the identified benchmarking enablers and develop an interrelationship diagram among the identified enablers.FindingsThis study benchmarks the potential enablers of I4.0 to achieve high ecological-economic-social gains in SCs considering the Indian scenario. Digitalization of the supply chain, decentralization, smart factory technologies and data security and handling are the most prominent enablers of I4.0 for SC sustainability to build a RSC.Originality/valueThe findings from the study may benefit managers, practitioners, specialists, researchers and policymakers interested in I4.0 sustainability applications.
Apocalypse unleashed: a critical perspective on complexity science, catastrophes, and black swan events in international business
Authors: Gonzales Martinez Rolando 
Published: January 2024

Purpose
The purpose of this study is to propose a methodological approach for modeling catastrophic consequences caused by black swan events, based on complexity science, and framed on Feyerabend’s anarchistic theory of knowledge. An empirical application is presented to illustrate the proposed approach.

Design/methodology/approach
Thom’s nonlinear differential equations of morphogenesis are used to develop a theoretical model of the impact of catastrophes on international business (IB). The model is then estimated using real-world data on the performance of multinational airlines during the SARS-CoV-2 (COVID-19) pandemic.

Findings
The catastrophe model exhibits a remarkable capability to simultaneously capture complex linear and nonlinear relationships. Through empirical estimations and simulations, this approach enables the analysis of IB phenomena under normal conditions, as well as during black swan events.

Originality/value
To the best of the author’s knowledge, this study is the first attempt to estimate the impact of black swan events in IB using a catastrophe model grounded in complexity theory. The proposed model successfully integrates the abrupt and profound effects of catastrophes on multinational corporations, offering a critical perspective on the theoretical and practical use of complexity science in IB.
Students' industrial work experience scheme (SIWES): exploring higher institution student’s participation and sense of belonging
Authors: Umar Musa Abba , Medan Penuel , Atiku Zainab Aliyu 
Published: January 2024

PurposeThe purpose of this study was to determine the extent to which students' industrial work experience scheme (SIWES) students in higher education institutions experienced a high level of engagement in workplace activities and a strong sense of affiliation with their workplace environment. The additional purpose encompassed the identification of factors that both facilitated and hindered their engagement and self-efficacy.Design/methodology/approachThe data for this study were collected via a cross-sectional survey of 243 students who were undertaking the SIWES as a mandatory component of their graduation requirements. The survey was conducted at selected tertiary institutions in Nigeria.FindingsThe qualitative replies yielded valuable insights on the factors that motivated and supported participation, with self-efficacy emerging as a significant facilitator as well as a potential barrier. There is a positive association between more interactions, a professional atmosphere and self-efficacy.Research limitations/implicationsThe study may not comprehensively include all contextual variables that might potentially impact students' perception of belongingness and self-efficacy during the SIWES program, including the distinct industry or workplace setting.Practical implicationsThis exploratory study analyzes SIWES students' cultural and personal affiliation. The study suggests these changes improve student performance. Engagement and belonging techniques for students, supervisors, coworkers and professionals are classified by the study. The study found that supervisors and coworkers help students at work. It underlines academics' responsibility in creating SIWES curricula that increase student confidence and active learning. According to this study, students should receive self-confidence therapy before SIWES. Self-confidence and student success and well-being need additional investigation, the report says.Originality/valueThis study takes a unique approach by examining belongingness and self-efficacy in the SIWES course. It examines the interdependence of these notions and the curriculum's various challenges and opportunities. By addressing these important issues, study adds to existing knowledge and lays the groundwork for future research.
Well-being of migrant workers in Taiwan during COVID-19 pandemic: the role of perceived organisational support, employee resilience and ethical leadership
Authors: Pham Loan Ngoc Tuong , Nguyen Duong Tuan , Vo An Hoang Kim , Nguyen Lam Dang 
Published: January 2024

Purpose The purpose of this paper is to investigate how perceived organisational support (POS) enhances the well-being of migrant workers in Taiwan by strengthening their resilience. In addition, the moderating role of ethical leadership in this association was investigated based on the conservation of resources (COR) theory.Design/methodology/approach The data were gathered from migrant workers from Southeast Asian countries, including Vietnam, Indonesia, Thailand and the Philippines with structured questionnaires during the COVID-19 pandemic. A total of 420 samples were analysed by testing the mediation and moderation model.Findings The results showed a significant effect of POS on migrant workers' well-being in Taiwan through the mediating role of resilience. Moreover, ethical leadership moderated the effect of POS on employee resilience and work well-being.Research limitations/implications The sample was restricted to Southeast Asian migrant workers who were employed in industrial sectors in Taiwan. The study considered several demographic variables, including language proficiency, nationality and marital status, which could result in cultural and language biases. A cross-sectional design and self-reported data were utilised, which could potentially create common method variance biases and inflated correlations across the research variables.Practical implications The present study may be helpful to organisational leaders in the process of designing approaches for promoting a people-oriented and harmonious workplace. Employee well-being can be strengthened through employee resilience (individual factors), as well as POS and ethical leadership (organisational factors).Originality/value This study supports the use of COR theory in confirming POS as a resource that strengthens employees' resilience capabilities and work well-being. Employee resilience serves as a mediator of the relationship between POS and employee well-being. Ethical leadership serves as a moderator in strengthening the relationships between POS and employee resilience, as well as between POS and work well-being of migrant workers.
A wavelet analysis of investing in cryptocurrencies in the Indian stock market
Authors: Jana Susovon , Sahu Tarak Nath 
Published: January 2024

PurposeThis study is designed to examine the dynamic interrelationships between four cryptocurrencies (Bitcoin, Ethereum, Dogecoin and Cardano) and the Indian equity market. Additionally, the study seeks to investigate the potential safe haven, hedge and diversification uses of these digital currencies within the Indian equity market.Design/methodology/approachThis study employs the wavelet approach to examine the time-varying volatility of the studied assets and the lead-lag relationship between stocks and cryptocurrencies. The authors execute the entire analysis using daily data from 1st October 2017 to 30th September 2023.FindingsThe result of the study shows that financial distress due to the pandemic and the Russian invasion of Ukraine have a negative effect on the Indian equities and cryptocurrency markets, escalating their price volatility. Also, the connectedness between the returns of stock and digital currency exhibits a strong positive relationship during periods of financial distress. Additionally, cryptocurrencies serve as a tool of diversification or hedging in the Indian equities markets during normal financial circumstances, but they do not serve as a diversifier or safe haven during periods of financial turmoil.Originality/valueThis study contributes to understanding the relationship between the Indian equity market and four cryptocurrencies using wavelet techniques in the time and frequency domains, considering both normal and crisis times. This can offer valuable insights into the potential of cryptocurrencies inside the Indian equities markets, mainly with respect to varying financial conditions and investment horizons.
Analyzing the market performance of Romanian firms: do the COVID-19 crisis and classification type matter?
Authors: Nuta Alina Cristina , Habib Ahmed Mohamed , Neslihanoglu Serdar , Dalwai Tamanna , Rangu Calin Mihai 
Published: January 2024

PurposeStock market performance is paramount to every country, as it signifies economic growth, business performance, wealth maximization, savings deployment and consumer confidence. This study investigates the disparities in the market performance of listed firms in Romania. This study also examines whether the COVID-19 crisis affected market performance.Design/methodology/approachThe data were collected from 69 firms listed on the Bucharest Stock Exchange (BSE) from 2018 to 2022, belonging to 11 sectors. This study used several methods to achieve its objectives. Difference tests were considered to analyze the performance of Romanian companies before and during the COVID-19 crisis, as well as across sectors. Regression analysis was also conducted to estimate the effect of the COVID-19 crisis and classification type on Romanian companies' performance. Additional analyses were performed to verify the findings of the present study.FindingsThe study’s findings indicate a clear difference in market performance between the pre-crisis and crisis periods. The COVID-19 pandemic had an adverse and significant impact on market performance. However, after the market contraction in the early stage of the COVID-19 pandemic outbreak, the stock market outperformed the pre-pandemic capitalization levels and the regional and global indices evolution. Furthermore, there was a difference in market performance across sectors. In particular, the communication services sector has specifically demonstrated accelerated growth.Originality/valueThis research examines the variation in the market performance of companies before and during the COVID-19 pandemic and across different sectors. It also provides evidence of the potential impact of COVID-19 on firms' market performance. This research contributes to a better understanding of how sectors perform during times of crisis.
Exploring gender inequality and sociocultural factors in Fiji: unveiling the “pink unicorns”
Authors: Saliya C.A. 
Published: January 2024

Purpose The purpose of this study is to explore the roles that sociocultural systems such as traditions, religious practices, and rituals play in upholding gender imbalance in Fiji.Design/methodology/approach This qualitative study relies on results from semi-structured interviews with auditors, educationalists, academics, partners from leading accounting/audit firms, company directors and high-ranked government officers. Thematic analysis was conducted both manually and using MAXQDA software, and the themes that emerged from both analyses are complementary. A few more complementary analyses were also conducted such as Word Cloud.Findings The results support the claim that the religious traditions and rituals are strongly linked to gender-inequitable beliefs and suggest sociocultural factors impose on women experiencing self-effacing emotions and passive acceptance of lower status, contributing to the persistence of gender inequality. It also emphasizes the need to challenge certain sociocultural practices to promote greater gender equality, which is the theme emerged from thematic analysis. Additionally, this paper proposes four distinct types of attitudes in this regard as self-effacing feminist, self-effacing traditional, self-effacing modesty and talented driven.Research limitations/implications Respondents' openness authenticity may be limited by factors like selection bias, small sample size and other potential constraints in this study.Practical implications The findings might influence stakeholders to advocate for policy changes to promote women's representation in leadership positions. The results give voice to various segments of society who are advocating greater gender diversity on board representation in Fiji. The themes immerged and theories developed would make a substantial contribution to the existing literature.Social implications The findings highlight the importance of addressing gender inequality in leadership positions to promote inclusive and sustainable growth.Originality/value This study sheds light on the less-explored domain of internal barriers to gender equality within Fiji. It adds a novel dimension to the understanding of how cultural norms intersect with individual perceptions to shape gender inequality.
Exploring the criteria for a green and smart hotel: insights from hotel managers' perspectives
Authors: Akel Gökhan , Noyan Elçin 
Published: January 2024

PurposeThis study aimed to explore the adaptations and perspectives of hotel managers regarding green and smart hotel technologies within the context of sustainability.Design/methodology/approachA comprehensive literature review guided the formulation of this study, followed by face-to-face, semi-structured interviews with hotel managers. A total of 17 prepared questions were finalized after examination by two expert academicians. The responses were analyzed using qualitative research methodology and the results were weighted using the step-wise weight assessment ratio analysis (SWARA) method.FindingsInterviews with sustainability and operational managers yielded insights into environmentally friendly practices and strategies such as reducing energy and water consumption, waste and chemical reduction, supporting local entrepreneurs and adopting smart technologies. These factors are crucial in eco-friendly hotels. According to the SWARA analysis, 'reducing energy consumption' is the most effective criterion.Research limitations/implicationsThis study offers insights into green and smart hotel management by focusing on the perspectives of hotel managers with a small sample. In future studies, research with larger samples on customer perspectives and the effect of hotel selection is recommended.Practical implicationsThis study offers insights to hotel managers on energy conservation and customer satisfaction enhancement through green and technological applications. These technological applications can improve hotel service quality and provide personalized experiences, fostering customer loyalty.Originality/valueThis pioneering study focuses on the intersection of green and smart practices in hospitality. By intertwining the often separately discussed concepts of “green” and “smart,” this study presents a novel approach to the sustainability practices in the hospitality industry, holding a key position, especially in Turkey. Implementing these concepts can yield environmental and economic benefits, offering invaluable insights to hotel managers and policymakers into integrating smart technologies with sustainability.
Are you hungry for play? Investigating the role of emotional attachment on continuance intention to use food delivery apps
Authors: Mai Xuan Tai , Trinh Thu Thi , Ryan Chris 
Published: January 2024

PurposeFood delivery apps (FDAs) have rapidly developed due to mobile technologies, changes in modern consumption and increased online use during the COVID-19 pandemic. Despite this, the platforms are struggling to build a stable customer base and make a profit. This study combined tech-driven motivators in an information system success model (ISSM) and emotional attachment operated by affect transfer theory (ATT) to explain why people might continue to use an FDA.Design/methodology/approachAn online quantitative cross-sectional survey was carried out via the Prolific platform. Data were collected from 416 FDA users and analyzed to test the hypotheses using the partial least squares based structural equation modeling.FindingsThe study found that system quality, information quality and emotional attachment directly influence the continued use of FDA. Moreover, the results suggest that perceived social interactivity and perceived playfulness are significant antecedents of emotional attachment.Research limitations/implicationsThe findings of this study enrich the current literature on continuance intention in online food delivery services by integrating the technology- and affective-based factors. The findings also provide various practical implications for app designers and marketers to foster an emotional bond with users, resulting in high retention rate.Originality/valueThe study proposes the integrated framework of ISSM and ATT for enhancing understanding of consumer behaviors in the post-adoption stage for FDA.