bluuebunny/crossref_metadata_2025_split huggingface dataset:
From pervasive chaos to evolutionary transition: The experience of healthcare providers during the COVID‐19 pandemic
Authors: Khoddam Homeira , Modanloo Mahnaz , Mohammadi Reza , Talebi Razieh 
Published: December 2023

AbstractAimThe outbreak of the COVID‐19 pandemic confronted healthcare providers, especially physicians and nurses, with many unprecedented changes and physical and psychological pressures. This study aimed to explore the healthcare providers' experiences providing healthcare services for patients during the COVID‐19 pandemic in “Golestan, Northeast Iran”.DesignQualitative, conventional content analysis.MethodsA total of 13 eligible participants were recruited through the purposeful sampling method. Data were gathered using semi‐structured in‐depth individual interviews. Transcripts were analysed using an inductive content analysis based on the Elo and Kyngas model. The COREQ checklist was used to prepare the manuscript.ResultsThe analysis of the data in this study led to the development of 16 subthemes and 5 themes emerged as follows pervasive chaos, imposed difficulties, paradoxical perceptions, committed efforts, and constructive transition.ConclusionThe experience of HCPs during the COVID pandemic in “Iran” showed that despite the physical, mental, emotional, and social consequences, a kind of constructive evolution and transition has also taken place in personal, professional, and organizational dimensions. It is suggested that managers while strengthening and protecting the capabilities and skills that have emerged, to reduce the tensions of HCPs, have developed programs for comprehensive support from them in physical, psychological, social, and financial dimensions.Relevance to Clinical PracticeIt is necessary to improve inter‐professional cooperation, empathy, teamwork, professional commitment, and continuous learning in crises.
Computational Studies for Development of Triazole‐Pyrimidines as Inhibitor of α‐Tubulin Receptor
Authors: Abdessadak Oumayma , Tabti Kamal , Alaqarbeh Marwa , Elmchichi Larbi , Koubi Yassine , Sbai Abdelouahid , Ajana Mohammed Aziz , Lakhlifi Tahar , Bouachrine Mohammed 
Published: December 2023

AbstractMicrotubules are among the critical targets for chemotherapeutic agents to fight against cancer because of their crucial role in mitosis. Microtubule inhibitors block cell cycle progression and result in apoptosis, they can frequently disrupt microtubule/tubulin dynamics by binding to the α‐tubulin receptor. To this end, we have developed compounds against α‐tubulin receptor using several tools of computational chemistry: 3D‐QSAR, Molecular Docking, Molecular Dynamics Simulation, and ADMET prediction. The significant findings incorporated two reliable models: CoMFA (Q2=0.75; R2=0.89) and CoMSIA (Q2=0.57; R2=0.78). Molecular Docking was generated and validated using Molecular Dynamics simulation to investigate the binding mode between the most active compound and the α‐tubulin receptor. The results of the MD simulation demonstrated stability over a 100 ns period. Four compounds (C1, C2, C3, and C4) were developed based on the contour maps, and their activities were predicted. Additionally, Molecular Docking was executed to elucidate the interaction and affinity between the novel compounds and the α‐tubulin receptor. C1 exhibited high affinity and essential interactions and was subjected to MD simulation studies. The results of the MD simulation revealed that the modifications made to enhance the anticancer activity did not impact stability. Finally, ADMET analysis was utilized to examine drug‐likeness.
Alysicarpus Vaginalis Plant‐Based Antioxidant Hybrid Nanocomposite‐MnFe2O4/AV for Water Treatment
Authors: Rathi Geetanjali , Singh Virendra , Chaudhry Saif Ali 
Published: December 2023

AbstractThe present study is focussed on the adsorptive removal of Crystal violet dye from laboratory polluted water using Alysicarpus vaginalis plant material based hybrid multifunctional nanocomposite which was prepared by following co‐precipitation method. The prepared composite MnFe2O4/AV has been characterised using FT‐IR, SEM‐EDX, TEM, XRD, BET, TGA techniques. The nanocomposite has been investigated for its antioxidant activity. The MnFe2O4/AV has been found possessing numerous functional groups on its porous surface and the sorption efficiency was evaluated in terms of parameters, such as sorbent dosage, concentration of the dye, contact time and pH of solution. The maximum adsorption capacity has been obtained as 34.211 mg g−1 and the process was found to be feasible and endothermic in nature. The data fitting showed that the sorption followed pseudo‐second order kinetics. From the sorption data fitting it was found that the sorption followed the Freundlich isotherm. Thus, the MnFe2O4/AV composite proved to be economical to synthesise which is eco‐friendly and has antioxidant ability, thus multifunctional in nature.
A Review of the Synthesis and Biological Activity of Flavonoid Mannich Base Derivatives
Authors: Nguyen Van‐Son , Cong Vo Thanh , Minh An Tran Nguyen 
Published: December 2023

AbstractOver the past twenty years (1998–2023), extensive research has focused on the synthesis and biological activity of Mannich base derivatives of flavonoids (FMBD), which have demonstrated exceptional properties towards organic and bioorganic molecules. Several research groups have reported the pharmacological potential of these flavonoid derivatives, including antioxidant and antiviral activities, as well as their ability to inhibit AChE and exhibit anticancer properties. Moreover, the unique characteristic of forming stable complexes with biomolecules positions flavonoid derivatives as valuable assets in the realm of biology and drug discovery. In this extensive review, we′ve meticulously analyzed over seventy six distinct research studies on this subject. Our aim is to provide a succinct overview of the wide‐ranging applications of flavonoid derivatives coupled with amines. Furthermore, we explore the promising horizons and potential innovations in this field. It's essential to highlight that these derivatives display no discernible signs of toxicity or eliciting immune responses, making them even more attractive for biopharmaceutical applications. Undoubtedly, the utilization of flavonoid derivatives combined with amines as crucial biopharmaceutical agents is poised for significant expansion in the forthcoming years.
3D Covalent Organic Frameworks from Design, Synthesis to Applications in Optoelectronics
Authors: Huang Wei , Zhang Weifeng , Yang Shuai , Wang Liping , Yu Gui 
Published: December 2023

AbstractCovalent organic frameworks (COFs), a new class of crystalline materials connected by covalent bonds, have been developed rapidly in the past decades. However, the research on COFs is mainly focused on two‐dimensional (2D) COFs, and the research on three‐dimensional (3D) COFs is still in the initial stage. In 2D COFs, the covalent bonds exist only in the 2D flakes and can form 1D channels, which hinder the charge transport to some extent. In contrast, 3D COFs have a more complex pore structure and thus exhibit higher specific surface area and richer active sites, which greatly enhance the 3D charge carrier transport. Therefore, compared to 2D COFs, 3D COFs have stronger applicability in energy storage and conversion, sensing, and optoelectronics. In this review, it is first introduced the design principles for 3D COFs, and in particular summarize the development of conjugated building blocks in 3D COFs, with a special focus on their application in optoelectronics. Subsequently, the preparation of 3D COF powders and thin films and methods to improve the stability and functionalization of 3D COFs are summarized. Moreover, the applications of 3D COFs in electronics are outlined. Finally, conclusions and future research directions for 3D COFs are presented.
Pathogen‐Activated Macrophage Membrane Encapsulated CeO2‐TCPP Nanozyme with Targeted and Photo‐Enhanced Antibacterial Therapy
Authors: Li Wen , Qi Manlin , Zhou Jing , Sun Yue , Sun Jiao , Dong Biao , Wang Lin , Song Shuyan 
Published: December 2023

AbstractNanozymes with peroxidase‐mimic activity have recently emerged as effective strategies for eliminating infections. However, challenges in enhancing catalytic activities and the ability to target bacteria have hindered the broader application of nanozymes in bacterial infections. Herein, a novel nanozyme based on mesoporous CeO2 nanosphere and meso‐tetra(4‐carboxyphenyl)porphine (TCPP) encapsulated within pathogen‐activated macrophage membranes, demonstrates photodynamic capability coupled with photo‐enhanced chemodynamic therapy for selective and efficient antibacterial application against infected wounds. Interestingly, the expression of Toll‐like receptors accordingly upregulates when macrophages are co‐cultured with specific bacteria, thereby facilitating to recognition of the pathogen‐associated molecular patterns originating from bacteria. The CeO2 not only serve as carriers for TCPP, but also exhibit intrinsic peroxidase‐like catalytic activity. Consequently, Staphylococcus aureus (S. aureus)‐activated macrophage membrane‐coated CeO2‐TCPP (S‐MM@CeO2‐TCPP) generated singlet oxygen, and simultaneously promoted photo‐enhanced chemodynamic therapy, significantly boosting reactive oxygen species (ROS) to effectively eliminate bacteria. S‐MM@CeO2‐TCPP specifically targeted S. aureus via Toll‐like receptor, thereby directly disrupting bacterial structural integrity to eradicate S. aureus in vitro and relieve bacteria‐induced inflammation to accelerate infected wound healing in vivo. By selectively targeting specific bacteria and effectively killing pathogens, such strategy provides a more efficient and reliable alternative for precise elimination of pathogens and inflammation alleviation in microorganism‐infected wounds.
Ñudzahui Custom, Contracts, and Common Lands in Eighteenth-Century Oaxaca
Authors: Yannakakis Yanna 
Published: December 2023

AbstractIndigenous communities in colonial Spanish America used imperial law to preserve, create, defend, and expand their landholding. This chapter analyzes Indigenous claims to customary land tenure and possession in response to a Spanish imperial program of land titling known as the composiciones de tierras and other challenges to communal territory in the Ñudzahui (Mixtec) region of Oaxaca. The land titling program dovetailed with the expansion of the livestock economy, population growth, and an increase in tribute and taxes during the late seventeenth and eighteenth centuries. In a context of increasing scarcity and pressure to normalize landholding, many Native communities went to court with competing claims to land. But Indigenous pueblos also came together to create plural ownership that allowed them to pool resources and share territorial jurisdiction. Through partnership contracts—the Spanish notarial form in which plural ownership was legally instantiated—Native authorities preserved or extended the territorial expanses of their communities, challenged or whittled away at the property of powerful Native elites (caciques), and transformed customary claims into new legal rights with an eye to securing the territorial integrity of their communities for the future.
The Yoreme Creation of Itom Ania in Northwestern Mexico: Histories of Cultural Landscapes
Authors: Radding Cynthia 
Published: December 2023

AbstractLanguage, traditional ecological knowledge, and the defense of territory come together in this chapter focused on the Yoreme communities of the Mayo river basin of northwestern Mexico. Language plays a fundamental role in our interpretation of the rich archival sources that allow us to comprehend the deeply rooted knowledge base that Indigenous peoples developed from their material and spiritual worlds. It is also an essential part of the living histories we construct in collaboration with the Indigenous peoples that maintain their traditions in a radically transformed ecological region through their ritual cycles and collective memories. The analysis of changes in land tenure and use presented here privileges Indigenous knowledge of landforms, biological species, and the cultural values that the communities of this region ascribed to the physical features and the territorial extension of the spaces they inhabited and defended. Its objectives seek to highlight the parallel production of oral and written sources and to contribute an historical analysis that is useful for the Yoreme communities in their present-day defense of their territory and its resources.
Shock waves in holographic EPR pair
Authors: Yeh Chen-Pin 
Published: December 2023

Abstract
We study real-time correlators for N = 4 super Yang Mill fields coupled to a pair of entangled quarks using holography, in the setup that energy quanta sent from one quark perturb the quantum state of the fields and affect the other quark. We make the connection with the ER=EPR conjecture by considering the situation when two quarks are uniformly accelerating opposite to each other. The dynamics of quarks, in the gravity dual, is described by the string worldsheet theory, which in this case has the induced metric describing a two-sided AdS black hole, or a wormhole. Energy quanta sent by one of the quarks produce the shock wave on the worldsheet. We find the effect of shock wave on the boundary field correlators and we discuss the consequence for the ER=EPR conjecture.
Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding
Authors: Bernard Chiara , Carotenuto Angelo Rosario , Pugno Nicola Maria , Fraldi Massimiliano , Deseri Luca 
Published: December 2023

AbstractCell membranes, mediator of many biological mechanisms from adhesion and metabolism up to mutation and infection, are highly dynamic and heterogeneous environments exhibiting a strong coupling between biochemical events and structural re-organisation. This involves conformational changes induced, at lower scales, by lipid order transitions and by the micro-mechanical interplay of lipids with transmembrane proteins and molecular diffusion. Particular attention is focused on lipid rafts, ordered lipid microdomains rich of signalling proteins, that co-localise to enhance substance trafficking and activate different intracellular biochemical pathways. In this framework, the theoretical modelling of the dynamic clustering of lipid rafts implies a full multiphysics coupling between the kinetics of phase changes and the mechanical work performed by transmembrane proteins on lipids, involving the bilayer elasticity. This mechanism produces complex interspecific dynamics in which membrane stresses and chemical potentials do compete by determining different morphological arrangements, alteration in diffusive walkways and coalescence phenomena, with a consequent influence on both signalling potential and intracellular processes. Therefore, after identifying the leading chemo-mechanical interactions, the present work investigates from a modelling perspective the spatio-temporal evolution of raft domains to theoretically explain co-localisation and synergy between proteins’ activation and raft formation, by coupling diffusive and mechanical phenomena to observe different morphological patterns and clustering of ordered lipids. This could help to gain new insights into the remodelling of cell membranes and could potentially suggest mechanically based strategies to control their selectivity, by orienting intracellular functions and mechanotransduction.
Cost-Availability Aware Scaling: Towards Optimal Scaling of Cloud Services
Authors: Bento Andre , Araujo Filipe , Barbosa Raul 
Published: December 2023

AbstractCloud services have become increasingly popular for developing large-scale applications due to the abundance of resources they offer. The scalability and accessibility of these resources have made it easier for organizations of all sizes to develop and implement sophisticated and demanding applications to meet demand instantly. As monetary fees are involved in the use of the cloud, one of the challenges for application developers and operators is to balance their budget constraints with crucial quality attributes, such as availability. Industry standards usually default to simplified solutions that cannot simultaneously consider competing objectives. Our research addresses this challenge by proposing a Cost-Availability Aware Scaling (CAAS) approach that uses multi-objective optimization of availability and cost. We evaluate CAAS using two open-source microservices applications, yielding improved results compared to the industry standard CPU-based Autoscaler (AS). CAAS can find optimal system configurations with higher availability, between 1 and 2 nines on average, and reduced costs, 6% on average, with the first application, and 1 nine of availability on average, and reduced costs up to 18% on average, with the second application. The gap in the results between our model and the default AS suggests that operators can significantly improve the operation of their applications.
Rising utilization of stable isotopes in tree rings for climate change and forest ecology
Authors: Huang Ru , Xu Chenxi , Grießinger Jussi , Feng Xiaoyu , Zhu Haifeng , Bräuning Achim 
Published: December 2023

AbstractAnalyses of stable isotopes (C, O, H) in tree rings are increasingly important cross-disciplinary programs. The rapid development in this field documented in an increasing number of publications requires a comprehensive review. This study includes a bibliometric analysis-based review to better understand research trends in tree ring stable isotope research. Overall, 1475 publications were selected from the Web of Science Core Collection for 1974–2023. The findings are that: (1) numbers of annual publications and citations increased since 1974. From 1974 to 1980, there were around two relevant publications per year. However, from 2020 to 2022, this rose sharply to 109 publications per year. Likewise, average article citations were less than four per year before 1990, but were around four per article per year after 2000; (2) the major subjects using tree ring stable isotopes include forestry, geosciences, and environmental sciences, contributing to 42.5% of the total during 1974–2023; (3) the top three most productive institutions are the Chinese Academy of Sciences (423), the Swiss Federal Institute for Forest, Snow and Landscape Research (227), and the University of Arizona (204). These achievements result from strong collaborations; (4) review papers, for example, (Dawson et al., Annu Rev Ecol Syst 33:507–559, 2002) and (McCarroll and Loader, Quat Sci Rev 23:771–801, 2004), are among the most cited, with more than 1000 citations; (5) tree ring stable isotope studies mainly focus on climatology and ecology, with atmospheric CO2 one of the most popular topics. Since 2010, precipitation and drought have received increasing attention. Based on this analysis, the research stages, key findings, debated issues, limitations and directions for future research are summarized. This study serves as an important attempt to understand the progress on the use of stable isotopes in tree rings, providing scientific guidance for young researchers in this field.
Noise from Unconventional Aircraft: A Review of Current Measurement Techniques, Psychoacoustics, Metrics and Regulation
Authors: Lotinga Michael J. B. , Ramos-Romero Carlos , Green Nathan , Torija Antonio J. 
Published: December 2023

Abstract
Purpose of Review
This review aims to evaluate and discuss the current advances in the measurement and assessment of the noise generated by unconventional aircraft, such as unmanned aircraft systems (UAS) and urban air mobility (UAM) vehicles. Building upon the findings of this review, research gaps are identified, and further work is proposed to enhance existing and emerging methods for the appropriate noise management of these advanced air mobility (AAM) technologies.

Recent Findings
Noise has been highlighted as one of the key concerns for the wider deployment of UAS and UAM operations. This is suggested to be due to having acoustic signatures with sound characteristics commonly associated with noise annoyance, such as ‘sharpness’ (the perceived proportion of high-pitched sonic energy) and ‘tonality’ (the perceptual prominence of concentrated sonic energy at discrete frequencies). These types of ‘psychoacoustic features’ are thought to be connected with observations of increased noise annoyance for AAM, compared with conventional aircraft and road vehicles, at the same level of sound exposure.

Summary
In the last few years, there has been a growing body of research on UAS and UAM noise. Research has focused on a comprehensive understanding of the sound sources of these unconventional aircraft under a wide range of operating and operational conditions. Based on gathered evidence, measurement protocols for both laboratory and field studies are very advanced for the acoustic characterisation of UAS in terms of sound level, frequency and directivity. Looking at the human response to UAS and UAM noise, loudness has been consistently reported as the main contributor to noise annoyance, with second-order contributions from other psychoacoustic features, such as sharpness, tonality and ‘amplitude modulation’ (fluctuations in loudness over time), varying among studies. Noise targets for UAS certification have been derived from existing regulations for conventional aircraft and rotorcraft, but might not account for the usually reported annoyance offset between UAS/UAM and conventional vehicles. Key research gaps identified include the lack of studies focusing on multiple events, and deeper understanding of the influence that personal or contextual factors may have on responses, which will be important for the development of robust methods for the assessment and minimisation of community noise annoyance due to the operation of these unconventional aircraft.

Graphical Abstract
Logistics of surgical missions during the war in Ukraine: lessons learned
Authors: Fuzaylov Gennadiy , Bean Christopher 
Published: December 2023

AbstractProviding surgical care for children living in warzones is a unique and complex issue. One solution to this problem is the delivery of surgical care through surgical/medical missions. However, significant issues exist when carried out in countries experiencing war or humanitarian crisis, including further stress placed on strained health systems, lack of availability of local resources to provide necessary support, and safety considerations for staff and patients. We describe our experience planning and carrying out a surgical mission to provide burn and reconstructive care to Ukrainian children by completing the surgeries in a nearby country, Poland. The necessary planning and logistics of such a mission are complex, including: patient recruitment, screening, selection, transportation between multiple countries, language and cultural barriers between medical teams as well as with patients, involvement of multiple governmental agencies, and facilitating appropriate follow-up care. However, this approach is worth exploring as it may carry some benefits in terms of resource utilization and complexity of care that is able to be provided.