bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Generalized Gamma-Weibull Distribution with Applications to Time-to-event Data
Authors: Dauda Kazeem Adesina , Lamidi Rasheed Kehinde , Dauda Adeshola Adediran , Yahya Waheed Babatunde 
Published: November 2023

AbstractIn this research, a new class of probability distributions referred to as Generalized Gamma Weibull (GGW) distributions was introduced within the context of parametric survival analysis. This distribution represents a modification of the gamma Weibull distribution and offers valuable insights, particularly when dealing with highly skewed lifetime data. The study extensively examined the mathematical characteristics of these distributions, encompassing hazard functions, moments, quantile functions, and order statistics. Furthermore, the research delved into parameter estimation methods for these newly proposed distributions, employing the maximum likelihood technique, Fisher Information (FI), and deriving asymptotic confidence intervals for both censored and uncensored scenarios. To illustrate the practical utility of these proposed distributions, the study applied them to analyze two sets of real-life survival data and two sets of real-life data, resulting in a total of four distinct datasets. To gauge the effectiveness of the GGW distributions in comparison to existing methods such as Generalized Weibull and Generalized gamma (G-Weibull and G-Gamma) distributions, the research employed statistical indices including the Akaike Information Criterion (AIC), Corrected Akaike Information Criterion (CAIC), and Bayesian Information Criterion (BIC). The outcomes of this comparative analysis demonstrated the superior performance of the newly introduced GGW distributions (AIC=338.6313, BIC=346.2794, and CAIC=339.5202) when contrasted with the existing methods (G-Weibull: AIC=376.1946, BIC=381.9307, and CAIC=376.5424) across all three criteria, thereby highlighting the enhanced suitability of GGW distributions for modeling and analyzing skewed lifetime data.
Changes in Secondary Structure and Properties of Bovine Serum Albumin as a Result of Interactions with Gold Surface
Authors: Komorek Paulina , Rakowski Kamil , Szota Magdalena , Lekka Małgorzata , Jachimska Barbara 
Published: November 2023

AbstractProteins can alter their shape when interacting with a surface. This study explores how bovine serum albumin (BSA) modifies structurally when it adheres to a gold surface, depending on the protein concentration and pH. We verified that the gold surface induces significant structural modifications to the BSA molecule using circular dichroism, infrared spectroscopy, and atomic force microscopy. Specifically, adsorbed molecules displayed increased levels of disordered structures and β-turns, with fewer α-helices than the native structure. MP-SPR spectroscopy demonstrated that the protein molecules preferred a planar orientation during adsorption. Molecular dynamics simulations revealed that the interaction between cysteines exposed to the outside of the molecule and the gold surface was vital, especially at pH = 3.5. The macroscopic properties of the protein film observed by AFM and contact angles confirm the flexible nature of the protein itself. Notably, structural transformation is joined with the degree of hydration of protein layers.Abstract Figure
Fluoxetine promotes immunometabolic defenses to mediate host-pathogen cooperation during sepsis
Authors: Gallant Robert M. , Snyder Jessica M. , Ayres Janelle S. 
Published: November 2023

AbstractSelective serotonin reuptake inhibitors (SSRIs) are some of the most prescribed drugs in the world. While they are used for their ability to increase serotonergic signaling in the brain, SSRIs are also known to have a broad range of effects beyond the brain, including immune and metabolic effects. Recent studies have demonstrated that SSRIs are protective in animal models and humans against several infections, including sepsis and COVID-19, however the mechanisms underlying this protection are largely unknown. Here we mechanistically link two previously described effects of the SSRI fluoxetine in mediating protection against sepsis. We show that fluoxetine-mediated protection is independent of peripheral serotonin, and instead increases levels of circulating IL-10. IL-10 is necessary for protection from sepsis-induced hypertriglyceridemia and cardiac triglyceride accumulation, allowing for metabolic reprogramming of the heart. Our work reveals a beneficial “off-target” effect of fluoxetine, and reveals a protective immunometabolic defense mechanism with therapeutic potential.
Comparison of urinary proteome in the first two days after mating in male rats
Authors: Wang Haitong , Zhao Chenyang , Gao Youhe 
Published: November 2023

AbstractObjectiveTo explore whether differences between male rats on the next day of mating and on the day of mating can be reflected by the urine proteome.MethodsUrine samples were collected from male Sprague-Dawley rats on the day of mating and the next day of mating. Urine samples were analysed by the free-labelled quantitative proteomics technique of high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS). Differential proteins of the urine proteome were analysed for protein function and biological pathways.Results43 differential proteins were identified by comparing the urine proteome of rats on the next day of mating with that on the day of mating, and nearly two-thirds of the differential proteins were related to spermatogenesis.ConclusionsThe urine proteome has the potential to reflect spermatogenesis without interfering with it.
Pathogen-prey-predator relations of avian raptors during epizootics of highly pathogenic avian influenza virus HPAIV H5N1 (clade 2.3.4.4b) in Germany
Authors: Günther Anne , Krone Oliver , Globig Anja , Pohlmann Anne , King Jacqueline , Fast Christine , Grund Christian , Hennig Christin , Herrmann Christof , Piro Simon , Rubbenstroth Dennis , Schulz Jana , Staubach Christoph , Stacker Lina , Ulrich Lorenz , Ziegler Ute , Harder Timm , Beer Martin 
Published: November 2023

AbstractTransition of highly pathogenic clade 2.3.4.4b H5 avian influenza virus (HPAIV) from epizootic to enzootic status in Northern European countries was associated with severe losses and even mass mortalities among various wild bird species. Both avian and mammalian raptors hunting infected debilitated birds or scavenging on virus-contaminated avian carcasses contracted HPAIV infection. This precarious pathogen-prey-predator relation further worsened when in 2021 and 2022 outbreaks in Germany overlapped with the hatching season of avian raptor species. Retro- and prospective surveillance revealed avian raptors as important indicators of HPAIV and its genetic diversity on the one hand. On the other hand, their role as victims of HPAIV is stipulated. The first case of an HPAIV H5N1-related death of a white-tailed sea eagle (Haliaeetus albicilla;WTSE) hatch in Germany, 2021, followed by several such cases in 2022, and a low overall seropositivity rate of 5.0-7.9% among WTSE nestlings, raised fears of a serious negative impact on reproduction rates of WTSEs and other birds of prey when HPAIV becomes enzootic in an ecosystem. However, comparably stable breeding success of WTSE in the study area in 2022 and a potentially evolving natural immunity raises hope for a less severe long-term impact.Article impact statementAdapted surveillance measures were developed to assess risks for the conservation of avian raptors due to the panzootic spread of HPAIV.
RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression
Authors: Bleve Augusto , Consonni Francesca Maria , Incerti Martina , Garlatti Valentina , Pandolfo Chiara , Monari Marta Noemi , Serio Simone , Pistillo Daniela , Sironi Marina , Alì Chiara , Manfredi Marcello , Finocchiaro Giovanna , Panico Cristina , Condorelli Gianluigi , Sica Antonio 
Published: November 2023

AbstractDespite well-documented metabolic and hematopoietic alterations during tumor development1, the mechanisms underlying this crucial immunometabolic intersection have remained elusive. Of particular interest is the ligand-activated transcription factor retinoic acid-related orphan receptor 1 (RORC1/RORγ), whose activity is boosted by cholesterol metabolites2, acting as a modulator of cancer-related emergency myelopoiesis3, while hypercholesterolemia itself is associated with dysregulated myelopoiesis4,5. Here we show that both cancer growth and hypercholesterolemic diet can independently or cooperatively activate RORγ-dependent expansion of myeloid-derived suppressor cells (MDSCs) and M2 polarization of tumor-associated macrophages (TAMs), thereby supporting cancer spread. Moreover, we report that tumor development enhances the hepatic production of IL-1β and IL-6, which in turn promote upregulation of hepatic proprotein convertase subtilisin/kexin type 9 (PCSK9) gene, as we confirmed in models of fibrosarcoma, melanoma, colorectal (CRC), and lung cancer, as well as in CRC, non-small-cell lung cancer (NSCLC), breast (BRC), pancreatic ductal adenocarcinoma (PDAC), biliary tract carcinoma (BTC) and pancreatic neuroendocrine tumor (PNET) patients. Importantly, lowering cholesterol levels prevents MDSC expansion and M2 TAM accumulation in a RORγ-dependent manner, unleashing specific anti-tumor immunity and improving the efficacy of anti-PD-1 immunotherapy. Overall, we identify RORγ as a novel sensor of lipid disorders in cancer bearers, bridging hypercholesterolemia and pro-tumor myelopoiesis.
Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks
Authors: Holmes Katie E. , VanInsberghe David , Ferreri Lucas M. , Elie Baptiste , Ganti Ketaki , Lee Chung-Young , Lowen Anice C. 
Published: November 2023

ABSTRACTFor many viruses, narrow bottlenecks acting during transmission sharply reduce genetic diversity in a recipient host relative to the donor. Since genetic diversity represents adaptive potential, such losses of diversity are though to limit the opportunity for viral populations to undergo antigenic change and other adaptive processes. Thus, a detailed picture of evolutionary dynamics during transmission is critical to understanding the forces driving viral evolution at an epidemiologic scale. To advance this understanding, we used a novel barcoded virus library and a guinea pig model of transmission to decipher where in the transmission process diversity is lost for influenza A viruses. In inoculated guinea pigs, we show that a high level of viral genetic diversity is maintained across time. Continuity in the barcodes detected furthermore indicates that stochastic effects are not pronounced within inoculated hosts. Importantly, in both aerosol-exposed and direct contact-exposed animals, we observed many barcodes at the earliest time point(s) positive for infectious virus, indicating robust transfer of diversity through the environment. This high viral diversity is short-lived, however, with a sharp decline seen 1-2 days after initiation of infection. Although major losses of diversity at transmission are well described for influenza A virus, our data indicate that events that occur following viral transfer and during the earliest stages of natural infection have a predominant role in this process. This finding suggests that immune selection may have greater opportunity to operate during influenza A transmission than previously recognized.
Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data
Authors: Huang Zhaoyang , Guo Xinyang , Qin Jie , Gao Lin , Ju Fen , Zhao Chenguang , Yu Liang 
Published: November 2023

AbstractRNA Velocity, as an extension of trajectory inference, is an effective method for understanding cell development using single-cell RNA sequencing (scRNA-seq) experiments. Nevertheless, existing RNA velocity methods are limited by the batch effect because they cannot directly correct for batch effects in the input data, which comprises spliced and unspliced matrices in a proportional relationship. This limitation can lead to incorrect velocity graphs. This paper introduces VeloVGI, which addresses this issue innovatively in two key ways. Firstly, it employs an optimal transport (OT) and mutual nearest neighbor (MNN) approach to construct neighbors in batch data. This strategy overcomes the limitations of existing methods that are affected by the batch effect. Secondly, VeloVGI improves upon VeloVI’s velocity estimation by incorporating the graph structure into the encoder for more effective feature extraction. The effectiveness of VeloVGI was demonstrated in various scenarios, including the mouse spinal cord and olfactory bulb, as well as on several public datasets. The results showed that VeloVGI outperformed other methods in terms of metric performance.Significance StatementRNA Velocity is an effective method for understanding cell development using single-cell RNA sequencing (scRNA-seq) experiments. This paper introduces VeloVGI, which addresses this batch effect issue for existing RNA velocity methods. The effectiveness of VeloVGI was demonstrated in various scenarios, including the mouse spinal cord and olfactory bulb, as well as on several public datasets. The results showed that VeloVGI outperformed other methods in terms of metric performance.
Mechanosensory and command contributions to theDrosophilagrooming sequence
Authors: Yoshikawa Shingo , Tang Paul , Simpson Julie H. 
Published: November 2023

SUMMARYFlies groom in response to competing mechanosensory cues in an anterior to posterior order using specific legs. From behavior screens, we identified a pair of cholinergic command-like neurons, Mago-no-Te (MGT), whose optogenetic activation elicits thoracic grooming by hind legs. Thoracic grooming is typically composed of body sweeps and leg rubs in alternation, but clonal analysis coupled with amputation experiments revealed that MGT activation only commands the body sweeps: initiation of leg rubbing requires contact between leg and thorax. With new electron microscopy (EM) connectome data for the ventral nerve cord (VNC), we uncovered a circuit-based explanation for why stimulation of posterior thoracic mechanosensory bristles initiates cleaning by the hind legs. Our previous work showed that flies weigh mechanosensory inputs across the body to select which part to groom, but we did not know why the thorax was always cleaned last. Here, the connectome for the VNC enabled us to identify a pair of GABAergic inhibitory neurons, UMGT1, that receive diverse sensory inputs and synapse onto both MGT and components of its downstream pre-motor circuits. Optogenetic activation of UMGT1 suppresses thoracic cleaning, representing a mechanism by which mechanosensory stimuli on other body parts could take precedence in the grooming hierarchy. We also mapped the pre-motor circuit downstream of MGT, including inhibitory feedback connections that may enable rhythmicity and coordination of limb movement during thoracic grooming.
How internet use affects personal privacy risk perception: empirical evidence from China
Authors: Liu Xiao Zhou , Ling Shuang , Liu Ying 
Published: November 2023

PurposeThis study aims to empirically examine the relationship between Internet use and personal privacy risk perceptions, the mediating effect of trust and the moderating effect of satisfaction on that relationship, which is exactly conducive to the practice of personal information protection.Design/methodology/approachA moderated mediation model will be employed to test the hypothesized relationships using the 2017 Chinese Society Survey data.FindingsThe authors find that Internet use positively relates to citizens' risk perceptions toward privacy security, and trust partially mediates the relationship between Internet use and privacy risk perception. In addition, the analysis of moderating effects showed that satisfaction with social life significantly enhances the negative impact on individuals' privacy risk perceptions of interpersonal trust. The positively moderating effect of satisfaction with local governments' work mainly reveals the relationship between interpersonal trust (or institutional trust) and citizens' privacy risk perception. Moreover, satisfaction with Internet platforms positively moderates the relationship between consumer trust and privacy risk perception.Originality/valueThis article contributes to the social risk amplification framework by applying it to the personal privacy information protection field, which was rarely discussed before. It also enriches privacy research by identifying the internal mechanism of how Internet use influences citizens' risk perceptions towards privacy information leakage.
Dynamic contexts for innovation strategy: Utilizing customer knowledge
Authors: Reinmoeller Patrick 
Published: November 2023

AbstractKnowledge and knowledge processes are fundamental for innovation. Innovation strategies have to use the complex and rapidly evolving environment. Planning with static contexts risks locking companies into past experiences and established practices—that is, existing technologies, products, and routines. Augmenting the dynamics of contexts is a key to creating new knowledge.This paper develops a framework for creating and utilizing dynamic contexts for design and innovation management. Five dimensions of dynamic contexts are illustrated: processes, people, relationships, technology, and leadership. Utilizing the dynamics enables companies to co‐create with markets—that is, create, shape, sustain, and exploit synchronic and diachronic knowledge processes for innovation.Two case studies of Seven‐Eleven and Muji illustrate how two internationally operating Japanese retailers implement innovation and design strategies through interaction with markets. The differences and family resemblance of the cases are analyzed.Conclusions and implications show how the business model of designing with markets can be adapted to individual companies.
Analysis of exponential corrected thermodynamic geometries in $$AdS_5\times S^5$$ black hole
Authors: Rani Shamaila , Iqbal Sadaf , Chaudhary Shahid 
Published: November 2023

AbstractThis paper delves the thermodynamics of 5-dimensional Schwarzschild $$AdS_5 \times S^5$$

A
d

S
5

×

S
5

black hole by considering the recently proposed effective models of exponential entropies. The conventional understanding of cosmological constant $$\Lambda $$
Λ
as thermodynamic pressure with volume being its counterpart cannot be directly applied in the framework of the AdS/CFT correspondence. In order to resolve this issue, we establish a connection between the cosmological constant $$\Lambda $$
Λ
in the boundary gauge theory and number of colors N while chemical potential is considered as thermodynamic conjugate. In this study, we replace the geometric parameters L and r of the AdS black hole with two thermodynamic parameters $$N^2$$

N
2

and S in the micro-canonical ensemble. Additionally, we explore the various thermodynamic geometry models such as Ruppeiner, Quevedo and Weinhold to derive the associated scalar curvatures for the 5-D Schwarzschild AdS BH. We analyze that these geometries exhibit microscopic attraction/repulsion forces on the particles of black hole.
Unveiling the unconventional optical signatures of regular black holes within accretion disk
Authors: Guo Sen , Huang Yu-Xiang , Cui Yu-Hao , Han Yan , Jiang Qing-Quan , Liang En-Wei , Lin Kai 
Published: November 2023

AbstractThe optical characteristics of three types of black holes (BHs) surrounded by a thin accretion disk are discussed, namely the Schwarzschild BH, Bardeen BH, and Hayward BH. We calculate the deflection angle of light as it traverses the vicinity of each BH using numerical integration and semi-analytical methods, revealing that both approaches can effectively elucidate the deflection of light around the BH. We investigate the optical appearance of the accretion disk and its corresponding observational images at various viewing angles, discovering that the luminosity in the region near the BH on the inner side of the accretion disk is higher than that on the outer side owing to higher material density in closer proximity to the BH. We observe a significant accumulation of brightness on the left side of the accretion disk, attributed to the motion of matter and geometric effects. Our findings emphasize the significant influence of the observation inclination angle on the observed outcomes. An increase in the observation inclination angle results in the separation of higher-order images. With the improvement in EHT observation accuracy, we believe that the feature of a minimal distance between the innermost region of the direct image of the Hayward BH and the outermost region of the secondary image can be used as an indicator for identifying Hayward BHs.
Considerações sobre a produção de açúcar e a lavoura de mantimentos em São Paulo na virada do século XVIII ao XIX
Authors: Micheli Marco 
Published: November 2023

O presente texto aborda aspectos da economia da capitania de São Paulo a partir de 1765, ano em que foi restabelecida sua autonomia política e administrativa. Desde então, o cultivo da cana e a produção de açúcar haviam sido introduzidos na capitania, visando ao incremento da economia paulista. São Paulo teve sua produção caracterizada pela diversificação dos gêneros agrícolas, política orientada para o abastecimento das tropas militares e da população regional, mas também para comercializar diretamente com o Reino. Nesse sentido, procuramos dar conta dos desafios que se colocaram no estudo da história
econômica de São Paulo, principalmente no que diz respeito à presença da cana-de-açúcar no espaço agrário paulista, marcado por unidades produtoras de variados mantimentos.
dízima da Alfândega da Bahia
Authors: Santos Gilberto dos 
Published: November 2023

O artigo apresenta os ajustes das funções da instituição alfandegária na capitania da Bahia, atribuindo o seu funcionamento, desde a primeira tentativa de estabelecimento da dízima da Bahia em 1711, ocasião em que a proposta da cobrança dos dez por cento sobre as entradas das fazendas no porto de Salvador levou à revolta da população, conhecida como o Motim do Maneta. O artigo também apresenta como contexto o aprofundamento da centralização administrativa e fiscal, sobretudo no governo do marquês de Angeja, proclamado o Vice-rei do Brasil em 1714. Essa figura estabeleceu a dízima alfandegária baiana, o regimento
e a cobrança da dízima da Alfândega da Bahia, bem como as questões que envolveram a pauta velha com
valores diminutos e a pauta nova que levaram a Coroa portuguesa colocar a dízima da Alfândega da Bahia em pregão no Conselho Ultramarino em 1720. Tendo como objetivo geral compreender como a arrecadação da dízima alfandegária colaborou para a reorganização das contas do Estado do Brasil e aprimoramento do processo de centralização fiscal e administrativo. A temática escolhida possibilitou observar que o estabelecimento da dízima da Alfândega da Bahia em 1714, deve ser entendido como medida chave do processo de centralização administrativa e fiscal da metrópole sobre a colônia. Ao instituir a dízima da Alfândega da Bahia, a metrópole passou a ter nova fonte de receita, um maior controle sobre as fazendas que entravam na colônia e ainda fechava brechas no exclusivo comercial metropolitano.
Cartas das crianças
Authors: Raffaini Patricia Tavares 
Published: November 2023

Durante as décadas de 30 e 40 os escritores: Monteiro Lobato, no Brasil, e Laura Ingalls Wilder, nos
Estados Unidos da América do Norte receberam de crianças leitoras centenas de cartas. Utilizando esse
corpo documental esse artigo pretende realizar uma análise comparativa das práticas de leitura literária
durante a infância nesses dois países, assim como também aborda alguns aspectos do papel social da
infância e as peculiaridades do que era ser criança nesses dois contextos.