bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethanol’s interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice
Authors: Okhuarobo Agbonlahor , Kreifeldt Max , Gandhi Pauravi J. , Lopez Catherine , Martinez Briana , Fleck Kiera , Bajo Michal , Bhattacharyya Pushpita , Dopico Alex M. , Roberto Marisa , Roberts Amanda J. , Homanics Gregg E. , Contet Candice 
Published: December 2023

AbstractLarge conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit have been nominally associated with alcohol use disorders. However, whether the action of ethanol at BK α influences the motivation to drink alcohol remains to be determined. To address this question, we first tested the effect of systemically administered BK channel modulators on voluntary alcohol consumption in C57BL/6J males. Penitrem A (blocker) exerted dose-dependent effects on moderate alcohol intake, while paxilline (blocker) and BMS-204352 (opener) were ineffective. Because pharmacological manipulations are inherently limited by non-specific effects, we then sought to investigate the behavioral relevance of ethanol’s direct interaction with BK α by introducing in the mouse genome a point mutation known to render BK channels insensitive to ethanol while preserving their physiological function. The BK α K361N substitution prevented ethanol from reducing spike threshold in medial habenula neurons. However, it did not alter acute responses to ethanol in vivo, including ataxia, sedation, hypothermia, analgesia, and conditioned place preference. Furthermore, the mutation did not have reproducible effects on alcohol consumption in limited, continuous, or intermittent access home cage two-bottle choice paradigms conducted in both males and females. Notably, in contrast to previous observations made in mice missing BK channel auxiliary β subunits, the BK α K361N substitution had no significant impact on ethanol intake escalation induced by chronic intermittent alcohol vapor inhalation. It also did not affect the metabolic and locomotor consequences of chronic alcohol exposure. Altogether, these data suggest that the direct interaction of ethanol with BK α does not mediate the alcohol-related phenotypes examined here in mice.
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
Authors: Kawatani Keiji , Holm Marie-Louise , Starling Skylar C. , Martens Yuka A. , Zhao Jing , Lu Wenyan , Ren Yingxue , Li Zonghua , Jiang Peizhou , Jiang Yangying , Baker Samantha K. , Wang Ni , Roy Bhaskar , Parsons Tammee M. , Perkerson Ralph B. , Bao Hanmei , Han Xianlin , Bu Guojun , Kanekiyo Takahisa 
Published: December 2023

AbstractABCA7 loss-of-function variants are associated with increased risk of Alzheimer’s disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7 deficiency on neuronal metabolism and function. Lipidomics revealed that mitochondria-related phospholipids, such as phosphatidylglycerol and cardiolipin were reduced in the ABCA7-deficient iPSC-derived cortical organoids. Consistently, ABCA7 deficiency-induced alterations of mitochondrial morphology accompanied by reduced ATP synthase activity and exacerbated oxidative damage in the organoids. Furthermore, ABCA7-deficient iPSC-derived neurons showed compromised mitochondrial respiration and excess ROS generation, as well as enlarged mitochondrial morphology compared to the isogenic controls. ABCA7 deficiency also decreased spontaneous synaptic firing and network formation in iPSC-derived neurons, in which the effects were rescued by supplementation with phosphatidylglycerol or NAD+ precursor, nicotinamide mononucleotide. Importantly, effects of ABCA7 deficiency on mitochondria morphology and synapses were recapitulated in synaptosomes isolated from the brain of neuron-specific Abca7 knockout mice. Together, our results provide evidence that ABCA7 loss-of-function contributes to AD risk by modulating mitochondria lipid metabolism.
Cancer-related fatigue trajectories up to 5 years after curative treatment for oesophageal cancer
Authors: Cheng Zhao , Johar Asif , Nilsson Magnus , Schandl Anna , Lagergren Pernilla 
Published: December 2023

Abstract
Background
Whether cancer-related fatigue develops differently after curative-intended oesophageal cancer treatment and the related modifiable factors are unclear.

Methods
This population-based and longitudinal cohort included 409 oesophageal cancer patients who underwent curative oesophagectomy in 2013–2020 in Sweden. The main outcome was cancer-related fatigue trajectories with measurements at 1, 1.5, 2, 2.5, 3, 4 and 5 years postoperatively by validated EORTC QLQ-FA12 questionnaire, and analysed using growth mixture models. Weighted logistic regressions provided odds ratios (OR) with 95% confidence intervals (95% CI) for underlying sociodemographic, clinical, and patient-reported outcome factors in relation to the identified trajectories.

Results
Two distinct overall cancer-related fatigue trajectories were identified: low level of persistent fatigue and high level of increasing fatigue, with 64% and 36% of patients, respectively. The odds of having high level of fatigue trajectory were increased by Charlson comorbidity index (≥ 2 versus 0: OR = 2.52, 95% CI 1.07–5.94), pathological tumour Stage (III–IV versus 0-I: OR = 2.52, 95% CI 1.33–4.77), anxiety (OR = 7.58, 95% CI 2.20–26.17), depression (OR = 15.90, 95% CI 4.44–56.93) and pain (continuous score: OR = 1.02, 95% CI 1.01–1.04).

Conclusions
Long-term trajectories with high level of increasing cancer-related fatigue and the associated modifiable factors were identified after oesophageal cancer treatment. The results may facilitate early identification and targeted intervention for such high-risk patients.
Design of ohmic contacts between Janus MoSSe and two-dimensional metals
Authors: Zhao Ning , Tyagi Shubham , Schwingenschlögl Udo 
Published: December 2023

AbstractTwo-dimensional semiconductors are considered as channel materials for field-effect transistors to overcome short-channel effects and reduce the device size. As the contacts to the metallic electrodes are decisive for the device performance, we study the electronic properties of contacts between Janus MoSSe and various two-dimensional metals. We demonstrate that weak interactions at these van der Waals contacts suppress Fermi level pinning and show that ohmic contacts can be formed for both terminations of Janus MoSSe, generating favorable transport characteristics.
Feasibility study of cryoballoon ablation for atrial fibrillation with KODEX-EPD: a single center experience
Authors: Wubulikasimu Subinuer , Wang Liang , Yang Suxia , Sang Wanyue , Han Yafan , Wang Lu , Wang Feifei , Zhou Xianhui , Zhang Jianghua , Xing Qiang , Tuerhong Zukela , Xiaokereti Jiasuoer , Guo Yankai , Tang Baopeng , Li Yaodong 
Published: December 2023

AbstractTo evaluate the feasibility of cryoballoon (CB) ablation of atrial fibrillation (AF) under the guidance of a new three-dimensional (3D) mapping system KODEX-EPD. 40 patients scheduled for CB ablation of AF in the first affiliated Hospital of Xinjiang Medical University from August 2021 to July 2022 were randomly divided into two groups: KODEX-EPD 3D mapping system guidance group (KODEX group, n = 20) and conventional two-dimensional perspective group (standard group, n = 20). The ablation time, operation time, fluoroscopy time, fluoroscopy dose, contrast agent dosage and follow-up data were compared between the two groups. Besides, the feasibility and accuracy of the dielectric sensing system in evaluating pulmonary vein (PV) occlusion in patients with AF during CB ablation were verified. All pulmonary veins were being isolated. The ablation time (36.40 ± 6.72 min vs 35.15 ± 6.29 min, P > 0.05) and the operation time (64.20 ± 11.82 min vs 66.00 ± 13.18 min, P > 0.05) were not statistically different in the two groups. The standard group has longer fluoroscopy time, dose and contrast medium dosage. There were significant differences in fluoroscopy time (532.30 ± 72.83 s vs 676.25 ± 269.33 s, P < 0.05), fluoroscopy dose (110.00 ± 28.64 mGy vs 144.68 ± 66.66 mGy, P < 0.05), and contrast medium dosage (71.90 ± 5.97 ml vs 76.05 ± 5.93 ml, P < 0.05) between the two groups. The learning curves of the first 5 patients and the last 15 patients in the KODEX group were compared. There was no statistical difference in the ablation time (36.80 ± 8.56 min vs 36.27 ± 6.34 min, P > 0.05) or the operation time (69.00 ± 5.00 min vs 62.60 ± 13.10 min, P > 0.05); however, compared to the first 5 patients, fluoroscopy time (587.40 ± 38.34 s vs 513.93 ± 73.02 s, P < 0.05), fluoroscopy dose (147.85 ± 35.19 mGy vs 97.39 ± 8.80 mGy, P < 0.05) and contrast medium dosage (79.60 ± 1.14 ml vs 69.33 ± 4.45 ml, P < 0.05) were significantly decreased. Using pulmonary venography as the gold standard, the sensitivity, specificity of the completely occlusion in KODEX group was 93.6% (95% CI 85–97.6%) and 69.6% (95% CI 54–81.8%); and the sensitivity, specificity of the small leak in KODEX group was 93.1% (95% CI 82.4–97.8%) and 82.0% (95% CI 65.9–91.9%). During an average follow-up of (9.90 ± 1.06) months, there was no statistical difference in arrhythmia recurrence and antiarrhythmic drugs taking after CB ablation between the two groups (P > 0.05). Using the KODEX-EPD system, the CB ablation procedure can correctly evaluate the PV occlusion, and significantly reduce fluoroscopy exposure and contrast medium without significantly increasing the operation time.
Age-related changes and sex differences in ankle plantarflexion velocity
Authors: Kanayama Atsuki , Yamamoto Saki , Ueba Ryoga , Kobayashi Mio , Ohmine Toshimitsu , Iwata Akira 
Published: December 2023

AbstractAnkle plantar flexors play a vital role in the mobility of older adults. The strength and velocity of plantarflexion are critical factors in determining walking speed. Despite reports on how age and sex affect plantarflexion strength, basic information regarding plantarflexion velocity is still lacking. This cross-sectional observational study investigated age-related changes and sex differences in plantarflexion velocity by comparing them with plantarflexion strength. A total of 550 healthy adults were classified into four age groups for each sex: Young (< 40 years old), Middle-aged (40–64 years old), Young-old (65–74 years old), and Older-old (≧ 75 years old). We measured plantarflexion velocity and strength in the long-sitting position using a gyroscope and a hand-held dynamometer, respectively. Two-way analysis of variance revealed no interaction between age and sex for either plantarflexion velocity or strength. Plantarflexion velocity exhibited a significant decline with aging, as did the plantarflexion strength. We found no significant sex differences in plantarflexion velocity in contrast to plantarflexion strength. The results indicated a significant decrease with age and no difference in plantarflexion velocity between males and females characteristic plantarflexion velocity. Understanding the characteristics of plantarflexion velocity could contribute to preventing a decline in mobility in older adults.
Modulating nickel-iron active species via dealloying to boost the oxygen evolution reaction
Authors: Wan Zhuqing , Guo Xiaolong , Jiang Junying , Xin Yuci , Tang Benzhen , Zhang Hong , Wu Yong , Xia Lei , Yu Peng 
Published: December 2023

Dealloying triggers the transformation of active species on Ni–Fe–P alloy: from γ-NiOOH to γ-NiOOH/FeOOH and then to β-NiOOH/FeOOH. FeOOH/NiOOH with a bifunctional mechanism promotes the Ni–Fe–P alloy to achieve the enhanced OER performance.
Hybrid traffic scheduling in time‐sensitive networking for the support of automotive applications
Authors: Nie Hongrui , Su Yue , Zhao Weibo , Mu Junsheng 
Published: December 2023

AbstractTime‐sensitive networking (TSN) is considered one of the most promising solutions to address real‐time scheduling in in‐vehicle network due to its capabilities for providing deterministic service. The TSN working group proposed various traffic shaping mechanisms, while deterministic scheduling of hybrid traffic is still not effectively solved since the traffic requirements are difficult to satisfy by standalone or combined mechanisms with fixed time slot divisions. This article presents a time‐aware multi‐cyclicqueuing and forwarding scheduling model, that integrates the no‐wait enabled time‐aware shaper and multi‐cyclic queuing and forwarding shaping models. Then, a scheduling solution, dubbed “TSN scheduling optimizer” (TSO) is proposed that combines optimization methods and incremental techniques. TSO aims to balance the load to maximize flow schedulability while guaranteeing the service requirements of hybrid traffic. Simulation evaluations through OMNeT++ provide a performance assessment of this proposed scheduling model, which can satisfy multiple types of traffic transmission requirements. Furthermore, TSO is compared with other baseline scheduling solutions, and TSO shows efficacy regarding execution time and schedulability.
Structured image diagnosis of vertebral body degeneration and disc damage – Binary image criteria and comparison for systematic image analysis in occupational diseases 2108/2110
Authors: Braunschweig Rainer , Kildal Daniela , Meyer-Clement Michael , Janka Rolf , Tiemann Andreas 
Published: December 2023

Background Occupationally related limitations of earning capacity can be recognized under social legislation and may be subject to compensation (“reduction in earning capacity”). For this purpose, legislators have defined a list of occupational diseases (“BK list”). Recognition of an occupational disease requires a legal assessment procedure based on a medical appraisal. The aim of the assessment is to prove the “causality” and the “causality giving rise to liability”.
Method In addition to clinical findings and workplace analyses, imaging methods (projection radiography, MRI) are primarily used to substantiate liability. These methods enable proof of load-conforming damage patterns for occupational diseases 2108/2110 (damage to intervertebral discs).
Results and Conclusion In addition to the legal background, the following review article primarily presents the image criteria for load-conforming damage patterns of the spine. On the basis of the consensus paper on the “Assessment of occupational disc diseases of the lumbar spine”, image criteria are assigned to age-atypical grades of findings, and “typical constellations of findings” are defined for vibration (BK 2108) or lifting (BK 2110) loads. The aim of Part 1 is to explain the image criteria of the comparative images presented as image plates in Part 2 and thus to present a reference catalog of findings.
Key statements
Citation Format
Estimation of Influenza Vaccine Effectiveness using Secondary Data: A
Cohort Study and Propensity Score-Matched Analysis of Claims Data from
Baden-Wuerttemberg
Authors: Wicke Felix , Lorenz Eva , Pokora Roman Michael 
Published: December 2023

AbstractOur objective was to estimate and replicate influenza vaccine effectiveness (VE)
for the 2014/2015 influenza season (IS) based on routine data from a
German health insurance claims dataset. In addition, we investigated associated
methodological aspects. From the AOK Baden-Württemberg, claims data of
2.64 million insured persons residing in Baden-Wuerttemberg and aged 15 years
and older were available for analysis. Based on influenza vaccine-specific
reimbursement codes claimed in the vaccination period of 2014, participants were
classified as either vaccinated or unvaccinated. Baseline covariates that could
confound the association between vaccination and influenza infection were
considered for all participants. Covariates included age, sex, place of
residence, and covariates indicative of health status and health-service
utilization. The primary outcome was defined as influenza hospitalization during
the IS in winter and spring of 2015. Secondary outcomes included pneumonia
hospitalizations, and all-cause mortality among others. Propensity score
matching (PSM) was used to build a comparable set of vaccinated and unvaccinated
participants. A bias analysis was conducted by estimating VE pre- and post-IS,
periods in which vaccination is not thought to be effective, because influenza
is not circulating in the population. A subset of 839,706 participants could
successfully be matched with a 1:1 ratio. The estimated influenza VE (based on
influenza hospitalization) was 27% [95% confidence interval
(CI): 17%; 36%], which compares well with the estimate of the
RKI for the same season (27% [95% CI: -1%;
47%]). Bias analysis revealed that result could be partially accounted
for by residual confounding yielding a potential overestimation of the true
underlying effect. Secondary outcomes for pneumonia hospitalizations and
mortality showed similar results though likely prone to a greater extent of
residual confounding. It can be concluded that (1) secondary data from German
health insurances can be used to derive plausible influenza VE estimates, and
(2) PSM is a useful and transparent method to derive those estimates. In
addition, (3) residual confounding is a relevant problem in observational
studies on VE and (4) bias analysis in pre- and post-season periods are an
essential complement for interpretation of results.
Hals, Nase und Ohren in der Schwerelosigkeit: die kosmischen Herausforderungen der HNO-Heilkunde
Authors: Zimmermann Philipp Heinrich , Jansen Stefanie , Klußmann Jens Peter 
Published: December 2023

ZusammenfassungDie bemannte Raumfahrt stellt besondere Anforderungen an den menschlichen Körper, auch an die Organe im HNO-Bereich. Diese Organe spielen eine entscheidende Rolle bei der Aufrechterhaltung der Gesundheit und Sicherheit der Astronauten im Weltraum. In diesem Beitrag werden häufige HNO-Probleme in der Raumfahrt besprochen, darunter Ödeme der oberen Atemwege, Mittelohr- und Mastoidergüsse, Hörverlust und Schwindel mit Übelkeit. Wir erörtern die zugrunde liegenden Mechanismen, die zu diesen Beschwerden beitragen, ihre klinischen Erscheinungsformen und mögliche Behandlungsstrategien. Darüber hinaus untersuchen wir die möglichen Auswirkungen dieser Erkrankungen auf die Gesundheit der Astronauten und die Ergebnisse der Mission. Schließlich betonen wir die Bedeutung von Präventivmaßnahmen und zukünftiger Forschung in diesem Bereich, um die Gesundheit und Sicherheit der Astronauten auf zukünftigen Missionen zu optimieren.
Versorgungstrajektorien wohnungsloser oder in prekären
Wohnverhältnissen lebender psychisch Erkrankter zweier
psychiatrisch-psychotherapeutischer Kliniken der Regelversorgung
Nordrhein-Westfalens
Authors: Zielasek Jürgen , Ueberberg Bianca , Heinz Josephine , Kreyenschulte Thea , Lehmann Isabell , Haussleiter Ida , Juckel Georg , Gouzoulis-Mayfrank Euphrosyne 
Published: December 2023

Zusammenfassung
Ziel der Studie Psychische Erkrankungen und Wohnungslosigkeit sind
häufig assoziiert. Ziel der Studie war die Darstellung der
Versorgungstrajektorien von stationären psychiatrischen
Patient*innen, die aus prekären Wohnverhältnissen oder
Wohnungslosigkeit aufgenommen wurden.
Methodik Eine anonymisierte Stichtagserhebung erfolgte in zwei
psychiatrischen Krankenhäusern der Regelversorgung in
Nordrhein-Westfalen.
Ergebnisse Von 76 identifizierten Betroffenen wurde etwa jeder Zweite in
ungesicherte Wohnverhältnisse oder die Wohnungslosigkeit entlassen. Bei
fast jedem Dritten verzögerte sich die Entlassung wegen der
ungeklärten Wohnsituation. Die ambulante psychiatrische Weiterbehandlung
konnte bei mehr als 30% und die hausärztliche Weiterbehandlung
bei mehr als 40% der Betroffenen nicht gesichert werden.
Schlussfolgerung Eine Verbesserung der Wohnsituation ist bei psychiatrisch
vollstationär Behandelten, die aus ungesicherten Wohnformen aufgenommen
wurden, in einer Minderzahl der Fälle möglich. Die
ungeklärte Wohnsituation wurde in etwa jedem dritten Fall als
Entlasshindernis angesehen.
Schwindel aus internistischer Sicht
Authors: Emrani Mahdi , Napp Andreas 
Published: December 2023

ZusammenfassungSchwindel ist ein Symptom, welches mehrere potenzielle Ursachen haben kann. Internistische und insbesondere kardiale Ätiologien sind oft mit einer eingeschränkten Prognose behaftet. Deshalb ist die Identifikation der zugrunde liegenden Ursache des Schwindels essenziell. Dieser Artikel soll einen Überblick über potenzielle internistische Schwindelursachen geben, wie eine differenzialdiagnostische Abklärung erfolgen sollte und therapeutische Herangehensweisen wichtiger ausgewählter Erkrankungen beschreiben.
HIIT Induces Stronger Shifts within the Peripheral T Cell Compartment
Independent of Sex
Authors: Proschinger Sebastian , Schenk Alexander , Metcalfe Alan J. , Zimmer Philipp 
Published: December 2023

AbstractAcute exercise induces changes within the T-cell compartment, especially in
cytotoxic CD8+ memory subsets, depending on exercise
intensity and duration. It is unclear whether exercise-induced changes in major
T-cell subsets differ in response to acute high-intensity interval training
(HIIT) or moderate-intensity continuous training (MICT) and whether sex-specific
effects exist. Twenty-four recreationally active runners (females: n=12,
27.8±4.1years,
54.4±4.6 ml*kg-1*min-1;
males: n=12, 31.6±3.8years,
58.9±7.7 ml*kg-1*min-1)
participated in this randomized controlled crossover study, and conducted an
energy- and duration-matched HIIT and MICT session. Blood was sampled before
(T1), immediately (T2) and 1 h after exercise
(T3). Flow cytometry was used to identify T-cell populations.
HIIT decreased the proportion of CD8+ T-cells more
pronounced at T3 compared to MICT (p=0.007), induced a
significantly stronger increase in the CD8+ effector
memory (TEM) cell proportion at T2 (p=0.032), and
decreased CD4+ central memory proportion more
pronounced at T2 (p=0.029). A decrease below baseline
CD8+ TEM proportion at T3
was observed only after HIIT (p<0.001). No interaction effects between
sexes were revealed. Taken together, HIIT represents a more potent stimulus to
induce shifts mainly within the cytotoxic CD8+ T-cell
compartment, thereby giving implications to investigate the role of HIIT on the
cell´s effector phenotype and function in more detail.
Wie gelingt die Einbindung von Betroffenen- und
Angehörigenvertreter:innen in die Entwicklung von evidenz- und
konsensbasierten Behandlungsleitlinien? Ergebnisse einer Umfrage im Fachbereich
Psychiatrie
Authors: Schladitz Katja , Weitzel Elena Caroline , Löbner Margrit , Soltmann Bettina , Jessen Frank , Schmitt Jochen , Pfennig Andrea , Riedel-Heller Steffi G. , Gühne Uta 
Published: December 2023

Zusammenfassung
Ziel Die Studie untersucht, wie gut die Beteiligung von Menschen mit
psychischen Beeinträchtigungen und Angehörigen an der
Entwicklung von psychiatrischen Leitlinien gegenwärtig gelingt.
Methodik Ergebnisse einer Umfrage unter N=561 (Response
37%) Entwickler:innen werden vorgestellt.
Ergebnisse Die Einbindung Betroffener gelingt häufiger gut als die
Angehöriger (61% vs. 55%). 68% stimmten zu, dass
deren Einbindung zentral für eine erfolgreiche Entwicklung ist.
51% sahen Diskrepanzen zwischen Evidenz und Betroffenen- und
Angehörigenperspektive. Benannt wurden auch eine mangelnde
Wertschätzung der Erfahrungsexpertise (33–36%),
ungenügende Repräsentanz (37%) und unzureichende
Gleichberechtigung in der Konsensfindung (46%). 45% sahen
Barrieren der Mitwirkung nicht wirksam abgebaut.
Schlussfolgerung Es bestehen weiterhin Herausforderungen bei der
Partizipation in der Leitlinienentwicklung. Gleichzeitig gibt es ein
Bewusstsein, dass diese für die Qualität einer Leitlinie zentral
ist. Es gilt, dieses Bewusstsein weiter auszubauen und den Herausforderungen
wirksam zu begegnen.