bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends of Staged Versus Single-Stage Operations for Bilateral Cleft Lip Repair: Analysis of a National Database
Authors: Lee Anna D. , Murphy Molly , Tin Giovanni , Alder Catherine , Chaij Jasmine , Porras Antonio , Yu Jason , French Brooke , Lowe Kristen , Nguyen Phuong D. , Mathes David , Khechoyan David 
Published: January 2025

Introduction:
Single-stage bilateral cleft lip repair may require preoperative naso-alveolar molding (NAM) to decrease cleft widths and reposition the premaxilla. Staged operations may be performed in centers or regions without easy access to NAM. This retrospective study aims to examine the national prevalence of single-stage and staged bilateral cleft lip repairs over the past 23 years.

Methods:
This retrospective study used TriNetX, a national deidentified aggregate database. The study used CPT codes to identify patients younger than 12 months who underwent single-stage (CPT-40701) or staged (CPT-40702) operation for bilateral cleft lip repair between 1/1/2000 to 9/16/2023. Patients were categorized by the year of their cleft lip repair. Patient demographics were analyzed through TriNetX. Linear regression analysis was conducted using PRISM software.

Results:
Of the 1303 patients who underwent bilateral cleft lip repair, 57 patients were billed for both operations and were excluded from the analysis. In the remaining cohort, 1136 (91%) patients had a single-stage, and 110 (9%) had a staged bilateral cleft lip repair. No significant demographic differences were found between the 2 groups.
The incidence of staged operations increased from 0 patients in 2000 to 14 patients in 2022. The incidence of single-stage operations increased from 6 patients in 2000 to 81 patients in 2022. Staged operations were rare in the first decade, accounting for 2% (n=5) of all bilateral cleft lip repairs between 2000 and 2011. The prevalence of staged operations showed a positive linear correlation (R
2=0.75, P<0.0001) over the 23-year period, rising from 0% (n=0) in 2000 to 17% (n=12) in 2023.

Conclusion:
Most bilateral cleft lip repairs have remained single-stage operations; however, staged approaches have also increased in popularity. This could indicate that NAM is less effective in patients with wide, severe bilateral cleft lip and palate, and surgeons may need to rely on a 2-stage approach for these patients.
Sagittal balance of the spine - a geometric force-line model
Authors: Song Kai , Wang Yu , Yang Qiang , Yang Cao , Wang Bing , Li Fangcai , Zhu Zezhang , Li Weishi , Zhang Jianguo , Wang Zheng 
Published: January 2025

AbstractObjectiveTo introduce a new geometric force-line model to assess the sagittal spinal-pelvic alignments and statistically analyze the main parameters of the model, offering a novel perspective for understanding the sagittal balance.MethodsA total of 388 healthy adults aged 18 - 35 years were recruited. To designate the mid-point of the anterior edge of the S2 vertebral body as the imaging marker point of the sagittal sacroiliac joint (SIJ). Parameters were measured included lines’ inclinations and angles related to T1, S2, HA (hip axis) and Co1(the first coccygeal).ResultsThe S2-T1 inclination angle was 89.5° ± 2.8°, close to perpendicular (90°), and it means the spinal axis (S2-T1) of the population is approximately perpendicular to the ground. In addition, spinal axis (S2-T1) crossed T11-L1 segments, which means spinal S curve is basically distributed on both sides of the axis. Angles ∠Co1-S2-HA, ∠HA-Co1-S2, and ∠S2-HA-Co1 were approximate 60°, forming a horizontal stable equilateral triangle. The anterior edge of S2 was nearly perpendicular to the pelvic force line (∠S2, HA-S2 ≈ 90°).ConclusionThe geometric performance of the proposed model is concise, clear, and logical. It provides a new perspective on the sagittal balance. This framework might help us better understand spinal-pelvic alignments and its clinical significance.
Bone Densitometry Dataset for Computer Aided Osteoporosis Disease Detection
Authors: Masnabadi Negin , Sadeghi-Niaraki Abolghasem , Karimi Mohammad , AbuHmed Tamer , Azarbani Nasrin , Choi Soo-Mi 
Published: January 2025

AbstractRecently, automatic disease diagnosis based on medical images has become an integral part of digital pathology packages. To create, develop, evaluate, and compare these systems, we need diverse data sets. One of the key features in the diagnosis of bone diseases is measuring bone mineral density (BMD). Most research in this field uses manual methods to directly extract bone image features despite the underlying correlation between diseased and healthy bones, which explains the limited results. Detection of significant changes in bone mineral density (BMD) relies on minimally invasive dual energy x-ray absorptiometry (DXA) scanners. This article presents a collection of bone density test results along with a patient profile called Arak Bone Densitometry Center data. The patient profile includes height and weight and information about the patient, along with photos of the imaging areas. The number of these patients is 3,643, with about 4,020 photos stored next to them. Which can be used to develop automatic disease diagnosis methods and software.Datasethttps://drive.google.com/drive/folders/1HmLTG4GFgB2s4D0×7TTRx8vV_VWY3sW3?usp=sharing
Risk Assessment ofEscherichia coliO157:H7 along the Farm-to-Fork Fresh-Cut Romaine Lettuce Supply Chain
Authors: Bulut Ece , Murphy Sarah I. , Strawn Laura K. , Danyluk Michelle D. , Wiedmann Martin , Ivanek Renata 
Published: January 2025

AbstractOutbreaks ofEscherichia coliO157:H7 (ECO157) in romaine lettuce remain an ongoing public health concern. Quantitative microbial risk assessment (QMRA) models are key tools for identifying control measures to mitigate foodborne diseases. Here, we introduce a comprehensive QMRA framework along the farm-to-fork fresh-cut romaine lettuce chain, including a novel preharvest difference equation model, to predict annual ECO157 illness cases in the United States and evaluate control strategies. We demonstrated the importance of managing irrigation contamination at preharvest to control illness cases. Wildlife intrusions pose lower health risk, followed by runoffs and biological soil amendments of animal origin. When preharvest contamination persists and combines with time-temperature abuses at postharvest, the predicted ECO157 illness cases rise considerably. We showed a broad range of interventions targeting both preharvest and postharvest stages can effectively improve the microbial safety of fresh-cut romaine. The comprehensive practices and interventions explored in this study will aid decision-makers in establishing/enhancing food safety best management practices.
The link between motor disorders and executive or attentional cognitive disorders in people with cerebral palsy: Scoping review
Authors: Martinet Melinda , Reichert Kathrin , Schneider Juliane , Matusz Pawel J. 
Published: January 2025

AbstractIntroductionCerebral palsy (CP) causes motor deficits, which are sometimes accompanied by cognitive impairment. There are models that suggest interactions between these two domains in various populations. However, for CP, there seems to be a lack of empirical research on the subject. This scoping review aims to synthesize the literature on the specific relationships between motor and executive/attentional functions in people with CP. In addition, it seeks to identify current gaps to guide future research.MethodA systematic search of three databases was conducted. Articles were selected on a double-blind basis according to predefined eligibility criteria. Finally, the results were presented in the form of tables and a narrative synthesis. This scoping review was written in accordance with the JBI manual for evidence synthesis.ResultsEleven studies with different methodologies were included in this review. Relationships were investigated in different ways in each of the included studies. Some articles assessed executive functions and attention in parallel, while others focused on the individual domains. Five of the included studies found significant links between motor and executive functions. Likewise, five studies reported significant relationships between motor skills and attention. However, three of the included studies found no evidence of links between certain of these domains.DiscussionThis work provides empirical evidence of the links between motor and executive/attentional functions in CP. For the future, there remains a need for more high-quality empirical studies to clarify and quantify the specific relationships of motor and executive/attentional abilities.
Joint association of genetic risk and accelerometer-based step count with cardiovascular disease: a UK-Biobank cohort study
Authors: Birmpili Panagiota , Portas Laura , Littlejohns Thomas J. , Doherty Aiden 
Published: January 2025

AbstractBackgroundThis population-based prospective cohort study aimed to investigate whether accelerometer-measured step count is associated with incident cardiovascular disease (CVD), independently from genetic risk.MethodsThe study included participants in the UK Biobank with valid accelerometer and genetic data and without prevalent CVD at baseline. Genetic risk for CVD was categorised as low (1stfifth), moderate (2nd-4thfifths), and high (5thfifth). Median daily step count was categorised as low (<6,500), moderate (6,500-12,499), and high (≥12,500). The association of genetic risk and step count with incident CVD, defined as a composite of coronary artery disease and ischaemic stroke, was examined using adjusted Cox proportional hazards models.ResultsOf 84,286 participants, 4,847 were diagnosed with CVD during follow-up (median 7.9 years). High genetic risk and low daily step count had a log-additive association with incident CVD. In low genetic risk individuals, step count was not associated with incident CVD. However, in the moderate and high genetic risk groups, those with low step counts had 24% (HR 1.24; 95% Confidence Interval [CI] 1.10-1.40) and 37% (HR 1.37; 95% CI 1.14-1.65) higher risk of incident CVD compared to those with high step counts. There was an inverse dose-response association between the hazard of CVD and step counts up to 10,000 steps/day, which then plateaued in moderate and high genetic risk groups.ConclusionsHigh daily step count was associated with lower CVD risk in individuals with moderate and high genetic risk, indicating that walking should be encouraged for all, especially those predisposed to CVD.
Surface Electromyographic Assessment of Pelvic Floor Muscles Protocol Tested by a Novel Airbag-type Stretchable Electrode Array (ASEA) Device in Stress Urinary Incontinence in Postmenopausal Women
Authors: Zhang Zujuan , Chen Qian , He Suyun , Li Wenjuan , Wang Shengming , Xie Zhenwei 
Published: January 2025

AbstractElectromyography (EMG) is a well-established method to quantify the PFM activity. The purpose of this study was to investigate the PFM of US and LAMs EMG variables separately by ASEA device and determine the predict value of sEMG for ASEA assessing the PFM in postmenopausal women with SUI. We obtained the EMG of US and LAMs separately by ASEA device consisted of following elements: ARP, MVC, TCP, ECP and PRP. We performed ROC curve analysis for optimal cutoff level for sEMG activation of the PFM. For 65 healthy and 67 with SUI, muscle strength was lower in SUI group according to the modified Oxford grading system by bidigital palpation. The sEMG of PFM activities were significantly lower in SUI group tested by ASEA device, especially in the MVC, TCP and ECP activities in US and LAMs. According to ROC curves, US and LAMs, especially PR and PC, except IC, have optimum predict cutoff amplitude for SUI. Our study proved that US defect and dysfunctional LAMs play an important role in the pathogenesis of SUI and separation of specific regions of US and LAMs can provide a reliable and optimized treatment strategy for the precise rehabilitation of pelvic floor muscles.
The Advanced Organ Support (ADVOS) hemodialysis system fulfills its intended purpose: Analysis of data from 282 patients from the Registry on Extracorporeal Multiple Organ Support (EMOS)
Authors: Fuhrmann Valentin , Tyczynski Bartosz , Perez Ruiz de Garibay Aritz , Bingold Tobias Michael , Weinmann-Menke Julia , Faltlhauser Andreas , Jarczak Dominik , Lutz Jens , Sander Michael , Klimpke Pascal , Koch Christian , Kribben Andreas , Boenisch Olaf , Kluge Stefan 
Published: January 2025

AbstractBackgroundSeveral case series have highlighted the ADVOS hemodialysis system’s efficacy in eliminating water-soluble and protein-bound substances across diverse patient populations, such as multiorgan failure, acute-on-chronic liver failure (ACLF), acidosis, and even COVID-19. The EMOS-Registry, a non-interventional, multi-center patient registry, amassed real-world evidence, culminating in the largest patient cohort treated with ADVOS to date. This study aims to present and analyze the final performance and safety outcomes from the entire dataset comprising 282 participants.MethodsData spanning from January 18, 2017, to August 31, 2020, were collected from five German hospitals, encompassing subsets of patients with acidosis and ACLF grade 3. Performance and safety were assessed through vital signs, clinical laboratory parameters and blood gas analyses. The SOFA Score-Standardized Mortality Ratio (SMR) served to evaluate patient outcomes in the absence of a control group.ResultsParticipants, with a median age of 58 years, predominantly male (64%), exhibited a high requirement for mechanical ventilation (68%) and vasopressors (82%) with a median SOFA Score of 15. Notably, a median of 3 (IQR 2, 5) ADVOS sessions per patient were administered.Following the initial treatment, significant reductions were observed in bilirubin (–1.9 [CI 95% –1.3, – 2.5]), creatinine (–0.5 [-0.4, –0.6]), and blood urea nitrogen (–13.1 mg/dL [-10.3, –16.0]) levels. Moreover, there were marked improvements in blood pH (7.34 vs. 7.41, p<0.001), HCO3-(19.4 vs. 24.6 mmol/l, p<0.001) and base excess (–5.6 vs. 0.2 mmol/l, p<0.001). The observed mortality rate (66%) was notably lower than the expected rate based on SOFA Score (84%), resulting in a SMR of 0.79 (95% CI: 0.66-0.93), with a calculated number needed to treat (NNT) of 5.8.ConclusionsThis study emphasizes the ADVOS system’s efficacy in eliminating water-soluble and protein-bound substances and correcting acid-base imbalances across a diverse cohort with multiorgan failure. However, further validation through randomized controlled trials is warranted to solidify these findings.Trial registration: DRKS00017068. Registered 29 April 2019 – Retrospectively registered,https://drks.de/search/en/trial/DRKS00017068
The current landscape of lifestyle and other non-pharmaceutical interventions in oncology in Africa: A review of registered clinical trials
Authors: Wangari Monica , Njoroge Eunice , Mburu Grace , Mogeni Brenda , Ouma Luke 
Published: January 2025

AbstractCancer is a significant public health issue in low—and middle-income countries, especially in Africa. While lifestyle and/or behavioral interventions such as exercise and dietary modifications are known to improve patient outcomes and quality of life, critical evidence from resource-limited settings like Africa is scanty. Here, we present a review of clinical trials on the current landscape of cancer associated lifestyle interventions in oncology in Africa. We comprehensively reviewed non-pharmacological/ lifestyle cancer-related clinical trials in Africa onClinicalTrials.govand ICTRP trial registries from 01 July 2005 to 30 October 2024. We employed descriptive analyses, primarily frequency and percentage, to analyze and report the data. Overall, 53 trials matching the criteria were identified. Most of the trials were in Egypt (38/53, 97.4%), Kenya (4/53,10.3%), and Nigeria (5/53, 12.9%). The top cancer types for the trials in Africa were breast 24/62, 45.3%), colorectal (6/62, 11.3%) and acute lymphoblastic leukemia (4/62, 7.5%). Concerning sponsorship, most trials were universities/academia-sponsored trials (45/53, 84.9%), locally sponsored (37/53, 69.8%), conducted among patients (88.7%), and 84.9% cancer survivors. Most trials involved physical activity interventions (25/53, 47.2%) and psychological and psychological interventions (10/53, 18.9%), with (32/53, 60.4%) trials completed and (13/53, 24.5%) trials ongoing. Non-pharmacological interventions for the management of cancer appear to be nascent in Africa. Oncology trials are needed to ensure the effectiveness of non-pharmaceutical/lifestyle interventions in Africa, especially sub-Saharan Africa (SSA). In the current era of precision medicine, pharmacological, and lifestyle interventions, it no longer suffices to assume that interventions in high—and upper-middle-income countries will be effective in low-middle-income countries, especially Africa.
Multimodal associations between posterior hippocampus glutamate metabolism, visual cortex connectivity, and intrusive trauma reexperiencing symptoms
Authors: Clancy Kevin J. , Chen Xi , Song Xiaopeng , Song Tao , Zhou Shuqin , Akman Eylül , Ostrand Caroline , Ren Boyu , Du Fei , Rosso Isabelle M. 
Published: January 2025

AbstractObjectiveHippocampal dysfunction is implicated in posttraumatic stress disorder (PTSD), particularly intrusive reexperiencing symptoms, and may be mediated by glutamatergic excitotoxicity. Markers of glutamate dysfunction (higher glutamate to N-acetyl aspartate levels; Glu/NAA) in the hippocampus (HPC) have been linked to reexperiencing symptoms. However, the HPC demonstrates heterogeneity along its anterior-posterior axis, with different functional connectivity patterns and PTSD symptom associations, motivating investigations into glutamate metabolism in anterior and posterior HPC subregions (a/pHPC).Methods121 symptomatic trauma-exposed adults (93 female) with current trauma reexperiencing symptoms completed magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging to examine the regional specificity of HPC Glu/NAA associations with reexperiencing, and the link to a/pHPC functional connectivity. PTSD symptoms were assessed with the Clinician-Administered PTSD Scale for DSM-5.ResultsReexperiencing symptom severity was associated with greater Glu/NAA in the pHPC, but not aHPC. pHPC Glu/NAA was further linked to stronger functional connectivity between the pHPC and visual cortex (VC), which in turn correlated with more severe reexperiencing symptoms. This strengthened pHPC-VC connectivity explained the shared variance between pHPC Glu/NAA and reexperiencing severity, suggesting dysregulated glutamate metabolism in the pHPC may contribute to reexperiencing symptoms through functional connectivity with the VC.ConclusionsThese findings replicate prior work linking HPC Glu/NAA to trauma reexperiencing symptoms and provide novel evidence this association may be specific to the pHPC and mediated by its functional connectivity with the VC. This multimodal investigation supports translational models of glutamatergic dysfunction in trauma-related disorders and highlights new targets for pharmacological and neuromodulatory interventions.
Cellular, Connectomic, and Cognitive Impact of Glioma and its Surgical Resection
Authors: Poologaindran A , Luppi AI , Hart MG , Santarius T , Price S , Sughrue ME , Seidlitz J , Bethlehem RAI , Assem M , Erez Y , Duncan J , Bullmore ET , Suckling J , Romero-Garcia R 
Published: January 2025

AbstractAwake surgery with intraoperative direct electrical stimulation (DES) is the gold-standard to maximize the extent of resection in diffuse cerebral gliomas (Duffau et al. 2023). While this approach is effective in testing for simple motor and language functions, it is inadequate for mapping higher-order cognitive functions such as attention, working memory, and cognitive control. Given that systems neuroscience is moving away from a localizationist to a connectomic perspective of human brain function, ideally, we could better understand how gliomas integrate within the connectome and how performing surgery on the brain’s mesoscale hub architecture affects long-term cognitive outcomes. To address problem, we combined cellular, connectomic, and cognitive data from healthy individuals (n=629) across the lifespan, cross-sectional glioma imaging (n=98), the Allan Human Brain Atlas (n=6), and a rare cohort of diffuse glioma patients (n=17) followed longitudinally as they underwent neurosurgery. First, we validate that meta-analytic cognitive activation maps co-localize with the Multiple Demand (MD) system and show that diffuse gliomas preferentially localize to the ‘core’ of this brain network. Second, cellular decoding of the MD core network reveals that it is uniquely enriched with oligodendrocyte precursor cells, glioma proto-oncogenes, and 5HT2-serotonergic neurotransmission. Third, the MD system is preferentially enriched for connector hubs to scaffolding the brain’s mesoscale hub architecture and that diffuse gliomas induce reorganization in this architecture thereby minimizing cognitive deficits. Lastly, surgical resection of connector, rather than provincial, hubs leads to long-term cognitive deficits while maintenance or dissolution of interhemispheric modularity predicted long-term cognitive outcomes. With the recent demonstration of the high concordance between DES and functional brain mapping (Saurrubo et al. 2024), this study provides new insight into how gliomas integrate within the connectome and that mapping the mesoscale hub architecture in each patient may improve presurgical mapping and postsurgical rehabilitation. Given the small but deeply sampled neurosurgical cohort, additional studies are now warranted to assess the value of mapping mesoscale connectivity for presurgical mapping and ‘interventional neurorehabilitation’ (Poologaindran et al. 2022).