bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trend analysis of precipitation, temperature and snow water equivalent in Lombardy region, northern Italy
Authors: Faquseh Hamzah , Grossi Giovanna 
Published: January 2024

AbstractThe analysis of precipitation, temperature, and snow water equivalent (SWE) trends offers a scientific approach for understanding the impacts of climate change. This paper presents a comprehensive analysis of climate change indicators in Lombardy, Italy, covering the yearly and monthly trends of precipitation and temperature from 1990 to 2020. Additionally, the yearly and monthly SWE variations. For this purpose, a range of statistical tests have been used including Mann–Kendall, Pettitt’s change point detection and Sen’s slope estimator. Precipitation trend shows a slight annual increase of around 5.42 mm per year. This trend is not statistically significant with a Mann–Kendall p value of 0.1448 and no changing point has been detected. Moreover, seasonal precipitation patterns show minor variations, with Kendall’s Tau values ranging from − 0.0431 to 0.1761. However, none of these trends are statistically significant, as reflected in Mann–Kendall p values ranging from 0.1679 to 0.7339. Conversely, Lombardy is experiencing a significant annual temperature increase of 0.0436 °C. Notably, in Autumn, temperatures rise at a rate of 0.0565° per year. Summer also shows a significant warming trend, with temperatures increasing by 0.0421° per year. In Winter and Spring, there are milder, non-significant temperature trends, with Kendall’s Tau values around 0.17. SWE trend shows minor annual variations (5–10%) and monthly shifts. Winter shows a slight decrease (2–3%), implying delayed snow accumulation, while Spring indicates minor change (1–2%) suggesting earlier snowmelt. This study emphasizes temperature's strong impact on SWE and stresses the importance of climate monitoring and collaboration for understanding changing climate patterns.
Experimental study on the production of carbon-absorbing backfill material from freshly mixed modified magnesium slag slurry
Authors: Sun Weiji , Liu Lang , Fang Zhiyu , Xie Geng , He Wei , Gao Yuheng 
Published: January 2024

AbstractWet carbonisation of alkaline industrial solid waste is considered to be an effective method for CO2 capture/processing of solid waste resources. Aiming at the high-value utilisation of modified magnesium slag in Shaanxi Province, a new method for producing carbon absorption backfill materials (CABM) is proposed by introducing CO2 into freshly mixed modified magnesium slag slurry. Through rheological, mini-slump, isothermal microcalorimeter test, uniaxial compressive strength, X-ray diffraction (XRD), thermogravimetry (TG-DTG) and scanning electron microscopy (SEM) experiments, the effects of CO2 on the fluidity, hydration, mechanical and microstructural properties of freshly modified magnesium slag slurry are investigated. The results show that: (1) while the introduction of CO2 significantly reduces the fluidity of a CABM, it can still meet the requirements of pipeline transportation in backfill mines; (2) the tiny calcium carbonate grains produced during the carbonation reaction can provide additional nucleation sites for the growth and diffusion of hydration products in CABM, and accelerate the hydration heat release rate; (3) the introduction of CO2 into the freshly mixed modified magnesium slag slurry not only helps to improve the compressive strength of the CABM samples at 28 days, but also has a good carbon absorption effect (5.2–7.6%); (4) through XRD, TG-DTG and SEM experiments, it is concluded that the carbonation reaction in the slurry does not prevent the further hydration of the modified magnesium slag, but is helpful for promoting a rapid hydration reaction in a later stage. Therefore, to maintain good fluidity and carbon absorption of the CABM, the backfill slurry should have a water/modified magnesium slag mass ratio of 0.5, a ventilation rate to of 1 L/min, and a ventilation stirring time of 5 min.
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats
Authors: Cieslik-Starkiewicz Agata , Noworyta Karolina , Solich Joanna , Korlatowicz Agata , Faron-Górecka Agata , Rygula Rafal 
Published: January 2024

Abstract
Background
The results of our previous studies demonstrated that low sensitivity to negative feedback (NF) is associated with increased vulnerability to the development of compulsive alcohol-seeking in rats. In the present study, we investigated the molecular underpinnings of this relationship.

Methods
Using TaqMan Gene Expression Array Cards, we analyzed the expression of the genes related to NF sensitivity and alcohol metabolism in three cortical regions (medial prefrontal cortex [mPFC], anterior cingulate cortex [ACC], orbitofrontal cortex [OFC]) and two subcortical regions (nucleus accumbens [Nacc], amygdala [Amy]). Gene expression differences were confirmed at the protein level with Western blot.

Results
Sensitivity to NF was characterized by differences in Gad2, Drd2, and Slc6a4 expression in the ACC, Maoa in the mPFC, and Gria1, Htr3a, and Maoa in the OFC. Chronic alcohol consumption was associated with differences in the expression of Comt and Maoa in the ACC, Comt, Adh1, and Htr2b in the mPFC, Adh1, and Slc6a4 in the Nacc, Gad2, and Htr1a in the OFC, and Drd2 in the Amy. Interactions between the sensitivity to NF and alcohol consumption were observed in the expression of Gabra1, Gabbr2, Grin2a, Grin2b, and Grm3 in the ACC, and Grin2a in the OFC. The observed differences were confirmed at the protein level for MAO-A in the mPFC, and ADH1 in the mPFC and Nacc.

Conclusions
Our findings contribute to a better understanding of the molecular mechanisms underlying the relationship between trait sensitivity to NF and compulsive alcohol consumption.
Towards sustainable battery recycling: selective dynamic adsorption of nickel(II) and cobalt(II) in an adsorbent fixed-bed reactor at elevated temperature
Authors: Robeck Björn , Horn Helena 
Published: January 2024

AbstractCaused by the scarce resources of critical heavy metals which are in high demand, e.g., for lithium-ion batteries, processes for the recovery of such materials for recycling are of high interest. Adsorption is an effective method in order to selectively separate metal ions from aqueous solutions. Unfortunately, the prerequisites in battery recycling, like acidic pH-value and high temperature, are in general impairing the adsorption process. In this study, the competitive dynamic adsorption of nickel(II) (Ni(II)) and cobalt(II) (Co(II)) by a silica adsorbent functionalized with amino-polycarboxylate derivative ligands (designated as HSU331) under recycling process conditions, (pH = 3.5, T = 20 °C, and T = 50 °C, respectively) and varying concentrations (Ni(II):Co(II) 1:1 (5.0, and 10 mmol·L−1, respectively), Ni(II):Co(II) 3:1 and 1:3 (3.0 mmol·L−1 and 1.0 mmol·L−1 vice versa)) were investigated. A displacement desorption of Co(II) in favor of the binding of Ni(II) was observed, achieving maximum loadings of 0.95 µmolNi(II)·µmolLigand−1 (28.3 mgNi(II)·gAdsorbent−1), and 0.48 µmolCo(II)·µmolLigand−1 (14.3 mgCo(II)·gAdsorbent−1) at T = 20 °C and 1.0 µmolNi(II)·µmolLigand−1 (29.9 mgNi(II)·gAdsorbent−1) and 0.18 µmolCo(II)·µmolLigand−1 (5.38 mgCo(II)·gAdsorbent−1) at T = 50 °C, respectively. These results demonstrate a distinctly selective separation of Ni(II) in the presence of Co(II) by HSU331, achieving an even higher efficiency at elevated temperatures.
Suggesting self-compassion training in schools to stop cyberbullying: a narrative review
Authors: Aledeh Muhammad , Sokan-Adeaga Adewale Allen , Adam Habib , Aledeh Sulaiman , Kotera Yasuhiro 
Published: January 2024

AbstractCyberbullying is a major public health problem among adolescents worldwide. Research shows that there is a link between cyberbullying and mental health problems. Adolescent victims of cyberbullying suffer from diverse negative effects such as stress, anxiety, depression, poor self-esteem, isolation, and suicidal ideation. Schools have attempted to address this by introducing measures, including raising awareness of cyberbullying among adolescents, launching Internet safety campaigns, and enacting regulations to stop cyberbullying. However, salient effects have not been reported to date. Research reports that self-compassion training is effective in reducing mental health problems and beneficial for adolescents. This narrative review aims to review the literature on cyberbullying in adolescence and propose effective measures to stop it. Self-compassion training is proposed as an effective intervention to stop cyberbullying among adolescents. This review further discusses how schools can implement self-compassion training to stop cyberbullying in adolescents. Findings will help policymakers and stakeholders of schools, colleges, and universities to incorporate self-compassion training into school curricula to help support victims of cyberbullying.
Low-dose esketamine improves acute postoperative pain in patients undergoing thoracoscopic surgery
Authors: Zhang Qing-wei , Wang Xin , Wang Zhong-yun , Sun He-liang 
Published: January 2024

Abstract
Purpose
The current study was designed to investigate the analgesic effect of esketamine on patients underwent thoracoscopic surgery and the underlying mechanism.

Methods
In this randomized, double blind, placebo-controlled study, 60 patients scheduled to undergo thoracoscopic lobectomy or segmentectomy were randomized to two groups to receive esketamine (group ESK) or saline (group SAL), respectively. 0.25 mg·kg−1 esketamine was given in group ESK for induction of anesthesia, and 0.12 mg·kg−1·h−1 esketamine for intraoperative maintenance. Group SAL received an equal volume of saline. The primary outcomes were the visual analogue scale (VAS) pain scores at rest and deep cough state which evaluated at departure from post-anesthesia care unit (PACU) (T1), 6 h, 24 h and 48 h after surgery (T2–T4). The secondary outcomes included the levels of white blood cell (WBC) count, absolute neutrophil count (ANC), interleukin-6 (IL-6), procalcitonin (PCT), anxiety/depression scores at T3, oxygen saturation (SpO2), and adverse reactions.

Results
Esketamine significantly decreased both rest and cough VAS pain scores at T1, and rest pain scores at T1, T2 and T4. Patients in ESK group had significantly lower WBC and ANC levels than SAL group, while the alteration of IL-6 and PCT levels between groups showed no significance. The anxiety scores of patients in both groups were significantly decreased after surgery. However, the depression scores of patients in ESK group did not decrease after surgery when compared with the preoperation. The postoperative SpO2 and the incidence of adverse reaction including postoperative nausea, vomiting, dizziness and dissociative symptom showed no significant difference between two groups (p > 0.05).

Conclusion
Esketamine can alleviate the acute postoperative pain of patients undergoing thoracoscopic surgery without increasing adverse reactions, and the underlying mechanism may be associated with the reduction of postoperative inflammation.

Trial registration
Registered at Chinese Clinical Trial Registry on February 7, 2022 (ChiCTR 2200056524).

Graphical Abstract
A study on distribution characteristics of volatile organic compounds in Paju industrial complex area, using proton transfer reaction-time of flight mass spectrometry
Authors: Kim So-Young 
Published: January 2024

AbstractPaju City is located in the northwest of Gyeonggi-do, and its chemical emissions in 2020 were 1,287,917 kg, the 4th highest in Gyeonggi-do. In particular, the Munsan High-Tech Industrial Complex in Paju has LCD manufacturing plants and partner companies distributed in groups, and the volatile organic compounds used by these companies are causing many problems, such as causing bad odors, to the local community. In this sense, real-time analyzing equipment (proton-transfer-reaction time-of-flight mass spectrometry) was mounted on a vehicle for this study to look into the air quality around VOCs-using companies inside the High-tech Industrial Complex in Munsan, Paju from October 19 to October 21, 2020.According to measurement results, toluene was detected the most at 25.7 ppb, followed by carbon tetrachloride (17.6 ppb), ethylbenzene (17.2 ppb), and xylene (8.5 ppb), which demonstrates that there is a need to control these substances to resolve the issue with VOCs in the region. In particular, benzene designated as the air quality standard was detected at 1.0 ppb in some sites, which is below the threshold (1.5 ppb). However, it was detected at 2.1 to 4.4 ppb, exceeding the threshold in most sites. Thus, continuous monitoring is expected to keep VOCs under control in Paju Industrial Complex down the road, using real-time measuring equipment.
A new eryopid temnospondyl from the Carboniferous–Permian boundary of Germany
Authors: Werneburg Ralf , Witzmann Florian , Rinehart Larry , Fischer Jan , Voigt Sebastian 
Published: January 2024

AbstractA new eryopid temnospondyl, Stenokranio boldi n. gen. n. sp. is described based on well-preserved cranial and postcranial material from fluvio-lacustrine deposits of the Permo-Carboniferous (Gzhelian/Asselian) Remigiusberg Formation at the Remigiusberg quarry near Kusel, Saar–Nahe Basin, southwest Germany. The new taxon is characterized by three autapomorphies within the Eryopidae: (1) the relatively narrow posterior skull table, therefore nearly parallel lateral margins of the skull; (2) the short postparietals and tabulars; and (3) the wide ectopterygoid. Phylogenetic analysis reveals a monophyletic Eryopidae with the basal taxa Osteophorus, Glaukerpeton, and Onchiodon labyrinthicus forming a polytomy. Actinodon may be either a basal eryopid or a stereospondylomorph, and the genus Onchiodon is not monophyletic. Stenokranio n. gen. is found as a more derived eryopid forming the sister taxon to Eryops. Stenokranio n. gen. was among the largest predators of the Saar–Nahe Basin. Its semiaquatic lifestyle enabled Stenokranio n. gen. to browse riverbanks and lake shorelines for prey, but most likely it fed on aquatic vertebrates. Stenokranio n. gen. was part of a faunal assemblage of aquatic, semiaquatic, and fully terrestrial vertebrates, such as sarcopterygian and actinopterygian fishes, xenacanthid sharks, a dvinosaurian temnospondyl, different “lepospondyls”, diadectomorphs, and synapsids. This is in general accordance with the vertebrate community from the Permo-Carboniferous of North America and from the early Permian localities of Manebach (Thuringian Forest Basin) and Niederhäslich (Döhlen Basin). It is notable that the occurrence of Stenokranio n. gen. and other eryopids in these localities excluded the presence of other large temnospondyls such as Sclerocephalus. However, a previously described isolated eryopid mandible from the Remigiusberg locality differs from that of Stenokranio n. gen. in several characters, implying that probably two different eryopid taxa lived at the same locality.UUID: www.zoobank.org/88a52547-d6fc-40af-965c-a6786c252ed5
Communicative remembering: Revisiting a basic mnemonic concept
Authors: Pentzold Christian , Lohmeier Christine , Birkner Thomas 
Published: January 2024

Abstract
The article attempts to clarify what today constitutes communicative remembering. To revisit this basic mnemonic concept, our theoretical contribution starts from available approaches in social memory studies that assume a binary distinction between cultural and communicative modes of memory making. In contrast, we use concepts that treat them not as structural, historically and culturally distinct registers but as a repertoire of retrospection that hinges on the evoked temporal horizon and media usage. To further interrogate this practical articulation of memories, we direct our attention to the habitual, communicatively realised engagement with the past. We finally turn to the ways communicative remembering is done in digitally networked environments, which provide us with a pertinent mnemonic arena where rigid dichotomies of communicative memory versus cultural memory are eroded.
The Role of the Stratosphere in Teleconnections Arising From Fast and Slow MJO Episodes
Authors: Yadav Priyanka , Garfinkel Chaim I. , Domeisen Daniela I. V. 
Published: January 2024

AbstractThe Madden‐Julian Oscillation (MJO) can influence the extratropical circulation on timescales up to several weeks, with a dependence on the MJO characteristics: MJO episodes that propagate slowly across the Maritime Continent have a stronger impact on Euro‐Atlantic weather than fast MJO episodes. While the tropospheric pathway for MJO teleconnections with varying phase speeds is well understood, in this study, we investigate the contribution of the Northern Hemisphere stratospheric pathway for fast versus slow MJO episodes. During slow MJO episodes, Phases 5–6 lead to increased upward wave propagation in the North Pacific sector, and subsequently enhanced heat flux at 100 hPa, leading to the weakening of the polar vortex. The results suggest a clear role of stratosphere‐troposphere coupling for slow MJO episodes, which is proposed as a mechanism for anomalously strong positive polar cap height anomalies in MJO Phases 7–8.
Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets
Authors: Hu Zhaoliang , Zhao Xushi , Wu Zhonghua , Qu Bicheng , Yuan Minxian , Xing Yanan , Song Yongxi , Wang Zhenning 
Published: January 2024

AbstractLymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various tissues and organs. They are tasked with a serious of responsibilities, including the regulation of lymph absorption and transport, the orchestration of immune surveillance and responses. Lymphatic vessel development undergoes a series of sophisticated regulatory signaling pathways governing heterogeneous-origin cell populations stepwise to assemble into the highly specialized lymphatic vessel networks. Lymphangiogenesis, as defined by new lymphatic vessels sprouting from preexisting lymphatic vessels/embryonic veins, is the main developmental mechanism underlying the formation and expansion of lymphatic vessel networks in an embryo. However, abnormal lymphangiogenesis could be observed in many pathological conditions and has a close relationship with the development and progression of various diseases. Mechanistic studies have revealed a set of lymphangiogenic factors and cascades that may serve as the potential targets for regulating abnormal lymphangiogenesis, to further modulate the progression of diseases. Actually, an increasing number of clinical trials have demonstrated the promising interventions and showed the feasibility of currently available treatments for future clinical translation. Targeting lymphangiogenic promoters or inhibitors not only directly regulates abnormal lymphangiogenesis, but improves the efficacy of diverse treatments. In conclusion, we present a comprehensive overview of lymphatic vessel development and physiological functions, and describe the critical involvement of abnormal lymphangiogenesis in multiple diseases. Moreover, we summarize the targeting therapeutic values of abnormal lymphangiogenesis, providing novel perspectives for treatment strategy of multiple human diseases.
Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
Authors: Tamlander Max , Jermy Bradley , Seppälä Toni T. , Färkkilä Martti ,   FinnGen, Widén Elisabeth , Ripatti Samuli , Mars Nina 
Published: January 2024

Abstract
Background
Hereditary factors, including single genetic variants and family history, can be used for targeting colorectal cancer (CRC) screening, but limited data exist on the impact of polygenic risk scores (PRS) on risk-based CRC screening.

Methods
Using longitudinal health and genomics data on 453,733 Finnish individuals including 8801 CRC cases, we estimated the impact of a genome-wide CRC PRS on CRC screening initiation age through population-calibrated incidence estimation over the life course in men and women.

Results
Compared to the cumulative incidence of CRC at age 60 in Finland (the current age for starting screening in Finland), a comparable cumulative incidence was reached 5 and 11 years earlier in persons with high PRS (80–99% and >99%, respectively), while those with a low PRS (< 20%) reached comparable incidence 7 years later. The PRS was associated with increased risk of post-colonoscopy CRC after negative colonoscopy (hazard ratio 1.76 per PRS SD, 95% CI 1.54–2.01). Moreover, the PRS predicted colorectal adenoma incidence and improved incident CRC risk prediction over non-genetic risk factors.

Conclusions
Our findings demonstrate that a CRC PRS can be used for risk stratification of CRC, with further research needed to optimally integrate the PRS into risk-based screening.
TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons
Authors: Yang Guolin , Jia Min , Li Guizhou , Zang Yan-Yu , Chen Yang-Yang , Wang Yue-Ying , Zhan Shi-Yu , Peng Shi-Xiao , Wan Guoqiang , Li Wei , Yang Jian-Jun , Shi Yun Stone 
Published: January 2024

AbstractThirst plays a vital role in the regulation of body fluid homeostasis and if deregulated can be life-threatening. Interoceptive neurons in the subfornical organ (SFO) are intrinsically osmosensitive and their activation by hyperosmolarity is necessary and sufficient for generating thirst. However, the primary molecules sensing systemic osmolarity in these neurons remain elusive. Here we show that the mechanosensitive TMEM63B cation channel is the osmosensor required for the interoceptive neurons to drive thirst. TMEM63B channel is highly expressed in the excitatory SFO thirst neurons. TMEM63B deletion in these neurons impaired hyperosmolarity-induced drinking behavior, while re-expressing TMEM63B in SFO restored water appetite in TMEM63B-deficient mice. Remarkably, hyperosmolarity activates TMEM63B channels, leading to depolarization and increased firing rate of the interoceptive neurons, which drives drinking behavior. Furthermore, TMEM63B deletion did not affect sensitivities of the SFO neurons to angiotensin II or hypoosmolarity, suggesting that TMEM63B plays a specialized role in detecting hyperosmolarity in SFO neurons. Thus, our results reveal a critical osmosensor molecule for the generation of thirst perception.