bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Introduction to SGTPPR: Sparse Geochemical Tectono‐Magmatic Setting Probabilistic MembershiP DiscriminatoR
Authors: Ueki Kenta , Hino Hideitsu , Kuwatani Tatsu 
Published: February 2024

AbstractWe present a new and easy‐to‐use geochemical tectono‐magmatic setting discriminator to calculate the probability of membership (the Sparse Geochemical Tectono‐magmatic setting Probabilistic membershiP discriminatoR, SGTPPR) that runs in Excel. It outputs the probability of membership for eight different tectono‐magmatic settings (mid‐ocean ridge, oceanic island, oceanic plateau, continental flood basalt province, intra‐oceanic arc, continental arc, island arc, and back‐arc basin) for a given volcanic rock sample based on major and selected trace element contents (SiO2, TiO2, Al2O3, Fe2O3, MgO, CaO, K2O, Na2O, Rb, Sr, Y, Zr, Nb, and Ba). We consider all possible ratios and multiplications of these contents, in addition to the contents themselves, which improves the discrimination accuracy. We use a statistical method called sparse multinomial logistic regression to construct a robust and predictive discrimination model. By imposing the sparsity, only a small number of essential variables are included in the model. The variables are objectively extracted from 287 possible geochemical variables, including all possible ratios and multiplications of the major and trace element contents. The constructed model exhibits a high classification ability, indicating that tectonic discrimination using major and selected trace elements yields a high classification ability when ratios and multiplications are considered. The system outputs the relative weights of the variables (i.e., contents, and ratios and multiplications of contents) of the input geochemical data to the calculated membership probabilities. This information can be used to evaluate and interpret the results. We apply the model to multiple samples of a geological unit, to determine the tectonic setting.
Long‐Term Decreasing of Sea Level Along Latitude of the Luzon Strait During 1993–2020: Surface Versus Subsurface Perspectives
Authors: Wu Baolan , Gan Jianping , Lin Xiaopei , Qiu Bo 
Published: February 2024

AbstractThe sea level in the east of Luzon Strait along the latitudinal band (18°–22°N, 125°–170°E) demonstrates a unique decreasing trend during 1993–2020, with weakening of eddy kinetic energy (EKE), weaker Kuroshio transport and stronger looping pathway in the Luzon Strait. Neither the surface wind forcing (remote Rossby wave and local Ekman convergence/divergence) nor surface buoyancy forcing (heat flux and Ekman thermal advection) could explain the observed sea level and EKE decreasing trend. From the subsurface perspective, by using the observational data analysis and ventilated thermocline theory, we propose that the reduction of mode water in the subsurface ocean contributes to the above changes during the past ∼30 years. The mode water forms primarily in the mid‐latitude and then is carried by the thermocline circulation southwestward after it subducts into the subsurface ocean. It takes ∼5 years for the mode water to arrive at the latitudinal band of Luzon Strait and affect the vertical stratification by changing the slope of thermocline. When the volume of mode water shrinks, the slope of thermocline would flatten, making the upper thermocline lift along the Luzon Strait latitudinal band. Whereafter, the subtropical front weakens, reducing the vertical velocity shear between the surface eastward Subtropical Counter Current and subsurface westward North Equatorial Current and sea level due to the baroclinic adjustment. Besides, the flattened thermocline and weakened vertical velocity shear results in the EKE reduction, which will contribute to the decreasing of sea level due to the weakened eddy‐forcing.
Stratospheric Aerosol Injection Geoengineering Would Mitigate Greenhouse Gas‐Induced Drying and Affect Global Drought Patterns
Authors: Liu Zhaochen , Lang Xianmei , Jiang Dabang 
Published: February 2024

AbstractStratospheric aerosol injection (SAI) is suggested as a potential measure for alleviating global warming. The potential effects of SAI on global temperature and precipitation have been extensively discussed, but its impact on drought has received little attention. Based on the simulations from the G6sulfur experiment that employs SAI to reduce the global mean surface temperature from the level of high‐tier forcing (Shared Socioeconomic Pathways SSP5‐8.5) scenario to that of medium‐tier forcing (SSP2‐4.5) scenario, we investigate the drought response to SAI via the standardized precipitation evapotranspiration index. During 2081–2100, SAI effectively offsets the greenhouse gas‐induced aridity trend by increasing the climate water balance at the global scale. Drought duration and severity decrease but drought frequency increases under SAI forcing. Robust wetting responses occur over most regions, especially the Sahara, South America, southern Africa and Australia, while Alaska, Greenland, Southeast Asia, and tropical Africa face enhanced drought due to SAI. Relative to the SSP2‐4.5 scenario, the regional drying and wetting patterns in G6sulfur are remarkably different. Notably, in tropical Africa, SAI reverses the wetting caused by greenhouse gases and induces severer drought. The drought pattern changes are largely due to evaporative demand alterations caused by the vapor pressure deficit response.
Europa's Double Ridges Produced by Ice Wedging
Authors: Cashion M. D. , Johnson B. C. , Gibson H. , Turtle E. P. , Sori M. M. , Melosh H. J. 
Published: February 2024

AbstractDouble ridges are sprawling features observed globally across the icy surface of Europa. They consist of two topographic highs flanking a trough. The topographic relief of the ridges is approximately 100 m, and the ridges extend up to hundreds of kilometers in length. The interior structure and dynamics of Europa's ice shell are currently poorly constrained. Therefore, accurate models for the formation of these prominent surface features can be useful for determining how the ice shell operates. We hypothesize that double ridges form as a result of incremental ice wedging. We use both analytical and numerical finite element models to quantify the deformation that occurs as an ice wedge grows incrementally within the ice shell. We show that incremental growth of the ice wedge results in surface deformation that matches the size and shape of typical Europan double ridges, including their topographic relief and surrounding troughs. We find that as the depth of the ice wedge increases, double ridges become broader and shorter. We explore the possibility of local and non‐local sources for the liquid water that freezes to produce the wedge and ultimately argue in favor of local sources of liquid water within the ice shell.
Impacts of Rainstorm Intensity and Temporal Pattern on Caprock Cliff Persistence and Hillslope Morphology in Drylands
Authors: Shmilovitz Yuval , Tucker Gregory E. , Rossi Matthew W. , Morin Efrat , Armon Moshe , Pederson Joel , Campforts Benjamin , Haviv Itai , Enzel Yehouda 
Published: February 2024

AbstractHillslope topographic change in response to climate and climate change is a key aspect of landscape evolution. The impact of short‐duration rainstorms on hillslope evolution in arid regions is persistently questioned but often not directly examined in landscape evolution studies, which are commonly based on mean climate proxies. This study focuses on hillslope surface processes responding to rainstorms in the driest regions of Earth. We present a numerical model for arid, rocky hillslopes with lithology of a softer rock layer capped by a cliff‐forming resistant layer. By representing the combined action of bedrock and clast weathering, cliff‐debris ravel, and runoff‐driven erosion, the model can reproduce commonly observed cliff‐profile morphology. Numerical experiments with a fixed base level were used to test hillslope response to cliff‐debris grain size, rainstorm intensities, and alternation between rainstorm patterns. The persistence of vertical cliffs and the pattern of sediment sorting depend on rainstorm intensities and the size of cliff debris. Numerical experiments confirm that these two variables could have driven the landscape in the Negev Desert (Israel) toward an observed spatial contrast in topographic form over the past 105–106 years. For a given total storm rain depth, short‐duration higher‐intensity rainstorms are more erosive, resulting in greater cliff retreat distances relative to longer, low‐intensity storms. Temporal alternation between rainstorm regimes produces hillslope profiles similar to those previously attributed to Quaternary oscillations in the mean climate. We suggest that arid hillslopes may undergo considerable geomorphic transitions solely by alternating intra‐storm patterns regardless of rainfall amounts.
Assessing Thermospheric Neutral Density Models Using GEODYN's Precision Orbit Determination
Authors: Waldron Z. C. , Garcia‐Sage K. , Thayer J. P. , Sutton E. K. , Ray V. , Rowlands D. D. , Lemoine F. G. , Luthcke S. B. , Kuznetsova M. , Ringuette R. , Rastaetter L. , Berland G. D. 
Published: February 2024

AbstractThis study focuses on utilizing the increasing availability of satellite trajectory data from global navigation satellite system‐enabled low‐Earth orbiting satellites and their precision orbit determination (POD) solutions to expand and refine thermospheric model validation capabilities. The research introduces an updated interface for the GEODYN‐II POD software, leveraging high‐precision space geodetic POD to investigate satellite drag and assess density models. This work presents a case study to examine five models (NRLMSIS2.0, DTM2020, JB2008, TIEGCM, and CTIPe) using precise science orbit (PSO) solutions of the Ice, Cloud, and Land Elevation Satellite‐2 (ICESat‐2). The PSO is used as tracking measurements to construct orbit fits, enabling an evaluation according to each model's ability to redetermine the orbit. Relative in‐track deviations, quantified by in‐track residuals and root‐mean‐square errors (RMSe), are treated as proxies for model densities that differ from an unknown true density. The study investigates assumptions related to the treatment of the drag coefficient and leverages them to eliminate bias and effectively scale model density. Assessment results and interpretations are dictated by the timescale at which the scaling occurs. DTM2020 requires the least scaling (∼−7%) to achieve orbit fits closely matching the PSO within an in‐track RMSe of 7 m when scaled over 2 weeks and 2 m when scaled daily. The remaining models require substantial scaling of the mean density offset (∼30 − 75%) to construct orbit fits that meet the aforementioned RMSe criteria. All models exhibit slight over or under‐sensitivity to geomagnetic activity according to trends in their 24‐hr scaling factors.
A Simple Model of Flood Peak Attenuation
Authors: Paiva Rodrigo C. D. , Lima Stefany G. 
Published: February 2024

AbstractA simple analytical model was developed for evaluating the attenuation of flood wave peak discharge. The physically‐based model represents the flood wave along its trajectory, based on the diffusive model. Relative peak discharge decreases along the downstream distance according to a power function. The distance is scaled by the attenuation factor related to river hydrodynamics (flow rating, hydraulic diffusivity, celerity, and floodplain storage) and input hydrograph (initial peak discharge, hydrograph volume, and its relative curvature). It also informs the attenuation length, which is a practical indicator of the river distance in which discharge decreases by a given factor. Sensitivity analyses indicate that initial peak discharge, volume, floodplain storage, and slope are the governing factors of attenuation. Model's validity and accuracy were demonstrated by reproducing data from (a) numerical solutions of the Saint‐Venant equations covering a wide range of conditions, (b) 29 observations from 11 historical dam‐breaks, (c) 15 observations of natural floods in seven rivers and (d) a detailed hydrodynamic model. The model errors were generally lower than 10% and not larger than the typical uncertainty of flood observations. The accuracy is higher than simplified empirical models and analogous to a detailed hydrodynamic model that is representative of current practice. The proposed flood attenuation model can be easily applied using a few common parameters and a simple equation in a basic spreadsheet. It is suitable for practical applications such as first assessments of natural and dam‐break floods, engineering design, and analyses of large river networks supported by remote sensing data.
Impacts of Topography‐Driven Water Redistribution on Terrestrial Water Storage Change in California Through Ecosystem Responses
Authors: Zhang Xue‐Yan , Fang Yuanhao , Niu Guo‐Yue , Troch Peter A. , Guo Bo , Leung L. Ruby , Brunke Michael A. , Broxton Patrick , Zeng Xubin 
Published: February 2024

AbstractLateral subsurface flow plays an essential role in sustaining the terrestrial ecosystem, but it is not explicitly represented in most Earth System Models. In this study, we implemented an explicit lateral saturated flow model into the E3SM land model (ELM). The model explicitly describes lateral flow in the saturated zone by representing, for each model grid, an idealized hillslope consisting of five hydrologically connected soil columns. We conducted three model experiments driven by 0.125° atmospheric forcing data during 1980–2015 over California using models of the default ELM, a modified version of ELM to enhance infiltration, and the model with the lateral saturated flow model. The simulated runoff, evapotranspiration, and terrestrial water storage anomaly (TWSA) from the three simulations were evaluated against available observations, and the model explicitly representing lateral flow performs best. The new model produces greater gridcell‐averaged evapotranspiration especially over the mountainous regions with moderate relief and seasonally dry climates. Most importantly, it improves the modeled seasonal variations, interannual variabilities, and the recent decadal decline of TWSA. Many of these improvements can be attributed to the enhanced ecosystem resilience to droughts as demonstrated by transpiration increases caused by lateral flow. Model sensitivity experiments suggest that subsurface runoff is most sensitive to the ratio between horizontal and vertical saturated hydraulic conductivity, followed by hillslope planforms (convergent, divergent, and uniform), number of columns, and lower boundary conditions. Future work should effectively characterize hillslopes in global models and explore the long‐term influences of lateral water movement on modeled biogeochemical cycle.
Correlation Structure of Steady Well‐Type Flows Through Heterogeneous Porous Media: Results and Application
Authors: Severino Gerardo , Fallico Carmine , Brunetti Guglielmo Federico Antonio 
Published: February 2024

AbstractSteady flow toward a fully penetrating well takes place in a natural porous formation, where the erratic spatial variations, and the raising uncertainty, of the hydraulic conductivity K are modeled within a stochastic framework which regards the log‐conductivity, ln K, as a Gaussian, stationary, random field. The study provides second order moments of the flow variables by regarding the variance of the log‐conductivity as a perturbation parameter. Unlike similar studies on the topic, moments are expressed in a quite general (valid for any autocorrelation function of ln K) and very simple (from the computational stand point) form. It is shown that the (cross)variances, unlike the case of mean uniform flows, are not anymore stationary due to the dependence of the mean velocity upon the distance from the well. In particular, they vanish at the well because of the condition of given head along the well’s axis, whereas away from it they behave like those pertaining to a uniform flow. Then, theoretical results are applied to a couple (one serving for calibration and the other used for validation purposes) of pumping tests to illustrate how they can be used to determine the hydraulic properties of the aquifers. In particular, the concept of head‐factor is shown to be the key‐parameter to identify the statistical moments of the random field K.
Oral health experiences of people living with Parkinson's disease: a scoping review
Authors: E. Tebbutt Jessie , Marshman Zoe , R. Baker Sarah 
Published: February 2024

AbstractBackground and aim Parkinson's disease is the fastest growing and second most common progressive neurodegenerative condition in the UK; poised to represent a major societal and health care challenge. The scoping review aims to provide an overview of the literature on the oral health (OH) experiences of people living with Parkinson's, identifying current research gaps and future priorities.Method Search strategies included three electronic databases, two grey literature databases, relevant organisations, specialist journals and hand searching of the reference lists. A data extraction tool was developed and piloted.Results A total of 121 items were included in the review. Four themes were identified: OH impact, education and training, service delivery and wider impacts of OH for people with Parkinson's (PwP). The majority of studies included were cross-sectional in design, describing the OH status of PwP.Conclusion The majority of research to date has focused on OH impact. Areas for future research include use of qualitative studies exploring the experiences, attitudes and priorities of PwP and their care partners. Inclusion of medical, dental and allied health care professionals, together with people with lived experience, is required to develop, implement and evaluate interventions to support OH.
The nuclear factor ID3 endows macrophages with a potent anti-tumour activity
Authors: Deng Zihou , Loyher Pierre-Louis , Lazarov Tomi , Li Li , Shen Zeyang , Bhinder Bhavneet , Yang Hairu , Zhong Yi , Alberdi Araitz , Massague Joan , Sun Joseph C. , Benezra Robert , Glass Christopher K. , Elemento Olivier , Iacobuzio-Donahue Christine A. , Geissmann Frederic 
Published: February 2024

AbstractMacrophage activation is controlled by a balance between activating and inhibitory receptors1–7, which protect normal tissues from excessive damage during infection8,9 but promote tumour growth and metastasis in cancer7,10. Here we report that the Kupffer cell lineage-determining factor ID3 controls this balance and selectively endows Kupffer cells with the ability to phagocytose live tumour cells and orchestrate the recruitment, proliferation and activation of natural killer and CD8 T lymphoid effector cells in the liver to restrict the growth of a variety of tumours. ID3 shifts the macrophage inhibitory/activating receptor balance to promote the phagocytic and lymphoid response, at least in part by buffering the binding of the transcription factors ELK1 and E2A at the SIRPA locus. Furthermore, loss- and gain-of-function experiments demonstrate that ID3 is sufficient to confer this potent anti-tumour activity to mouse bone-marrow-derived macrophages and human induced pluripotent stem-cell-derived macrophages. Expression of ID3 is therefore necessary and sufficient to endow macrophages with the ability to form an efficient anti-tumour niche, which could be harnessed for cell therapy in cancer.
Comparative overall survival of CDK4/6 inhibitors in combination with endocrine therapy in advanced breast cancer
Authors: Kappel Coralea , Elliott Mitchell J. , Kumar Vikaash , Nadler Michelle B. , Desnoyers Alexandra , Amir Eitan 
Published: February 2024

AbstractIndividual trials of abemaciclib, palbociclib, and ribociclib show a similar impact on progression-free survival yet differing statistical significance for overall survival (OS). A robust comparative evaluation of OS, safety, and tolerability of the three drugs is warranted. A systematic literature search identified phase 3 randomized clinical trials reporting OS of CDK4/6 inhibitors (CDK4/6i) in combination with endocrine therapy in ER-positive/HER2-negative advanced breast cancer. Trial-level data on OS and common and serious adverse events (AE) were extracted for each drug. In the absence of direct comparisons, a network meta-analysis was performed to evaluate pairwise comparative efficacy, safety, and tolerability of each of the CDK4/6i. Seven studies comprising of 4415 patients met the inclusion criteria. Median follow-up was 73.3 months (range: 48.7–97.2 months). There were no statistically significant differences in OS between any of the CDK4/6i. Compared to palbociclib, ribociclib and abemaciclib both showed significantly higher GI toxicity (grade 1–2 vomiting OR 1.87 [95% CI 1.37–2.56] and OR 2.27 [95% CI 1.59–3.23] respectively). Compared to palbociclib, abemaciclib was associated with more grade 3–4 diarrhea OR 118.06 [95% CI 7.28–1915.32]. In contrast, palbociclib was associated with significantly more neutropenia than ribociclib and abemaciclib but significantly lower risk of grade 3–4 infections. Abemaciclib had significantly less grade 3–4 transaminitis and grade 3–4 neutropenia than ribociclib. Treatment discontinuation and death due to AE were significantly higher with abemaciclib than palbociclib and ribociclib. There is no statistically significant difference in OS between CDK4/6i despite differing statistical significance levels of individual trials. Real-world data analyses may help to identify if there is a meaningful inter-drug difference in efficacy. Significant differences between CDK4/6i are observed for safety and tolerability outcomes.
Investigating bacteriophages as a novel multiple-hurdle measure against Campylobacter: field trials in commercial broiler plants
Authors: Bogun Katrin , Peh Elisa , Meyer-Kühling Borris , Hartmann Jürgen , Hirnet Juliane , Plötz Madeleine , Kittler Sophie 
Published: February 2024

AbstractCampylobacter mitigation along the food production chain is considered effective for minimizing the public health burden of human campylobacteriosis. This study is the first combining different measures in a multiple-hurdle approach, using drinking water additives and feed additives in single and combined application schemes in commercial broiler plants. Broiler chickens in the study groups were naturally contaminated with Campylobacter. Application of an organic acid blend via drinking water, consisting of sodium propionate, potassium sorbate, and sodium diacetate, resulted in significant reductions of up to 4.9 log10 CFU/mL in fecal samples and in cecal samples at slaughter. The application of a phage mixture, consisting of Fletchervirus phage NCTC 12673 and Firehammervirus phage vB_CcM-LmqsCPL1/1, resulted in reductions of up to 1.1 log10 CFU/mL in fecal samples 1 day after dosing. The sole administration of curcumin via feed resulted in small and inconsistent reductions. In the group receiving a combination of all tested measures, reductions of up to 1.1 log10 CFU/mL were observed. Based on the results of our field trials, it was shown that both the sole application and the combined application of mitigation measures in primary production can reduce the Campylobacter load in broiler chickens, while no synergism could be observed.