bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serbia-China bilateral trade relations: major challenges and opportunities
Authors: Jovičić Elena , Stevanović Slavica , Beraha Isidora 
Published: November 2023

Considering the growing presence of China in Serbia and deepening the overall bilateral relations, the main objective of the paper is to analyze the major trends and changes in the bilateral merchandise trade between both countries. The paper also focuses on exploring the main challenges as well as determinants for enhancement of trade relationships in the upcoming period.
The total trade between Serbia and China has been steadily growing over the last decade. The value of total trade in 2019 compared to 2010 is increased by twice, the value of imported and exported goods grew twice and almost 45 times, respectively. Despite the rapid growth, the Trade Intensity Index shows that trade between Serbia and China is under-represented, implying there is a space for improvement.
Some obstacles hinder trade relations between Serbia and China. One of the main challenges stems from the fact that China shares its influence in Serbia using investments rather than trade. On the other side, Serbia does not have enough capacity to meet Chines market demand, which is among other things is a result of the domination of low value-added products in the total Serbian exports.
In order to overcome the obstacles, Serbia should focus on its comparative advantage as well as attracting the Chinese investment in the strategically important sectors. Furthermore, it is essential for Serbia to develop a strategic approach to trade policy towards China, which implies better promoting of export growth, relevant support of Serbian exporters as well as more active engagement around trade matters during official negotiations with China.
DETERMINANT FACTORS OF AIR QUALITY: EMPIRICAL STUDY IN JAVA ISLAND
Authors: Setiawan Havidz Aldi , Lutfi Muhammad , Rahmayani Dwi 
Published: November 2023

Air pollution is one of several environmental problems faced by several countries in the world, including Indonesia. Air pollution caused many environmental problems such as global warming and climate change. Air pollution increased due to human activity and economic development. Economic activities such as industry, infrastructure development to community mobility can affect air quality in an area. The study aimed to analyze the impact of income per capita, transportation, and population on the air quality of six provinces in Java Island. This study obtained data from the National Statistic Central Bureau and the Ministry of Forestry websites from the year 2013-to 2019. This study was using a quantitative method through the regression model with panel data to achieve the research's goals. The result showed that the variable of income per capita has negative effects on air quality. The variable of income per capita is described by the economic activity of people in Java Island. The results of this study indicate that the economic activities of people in Java Island still have a negative impact on the environment, especially on the air quality. The opposite result was obtained from transportation and population variables that have a positive effect on air quality in the six provinces in Java Island from 2013 to 2019.
Cardiac manifestations of MIS-C: cardiac magnetic resonance and speckle-tracking data
Authors: Scarduelli Lorenzo , De Guillebon De Resnes Jean-Marie , Ducreux Dorothée , Bernardor Julie , Afanetti Mickael , Dupont Audrey , Barthelemy Sébastien , Gondon Emmanuelle , Leporati Julien , Giovannini-Chami Lisa , Moceri Pamela 
Published: November 2023

BackgroundCardiac involvement is central in MIS-C and represents the main cause of morbidity. In this study, we aimed to assess myocardial damage in patients with MIS-C using cardiac magnetic resonance (CMR) during the acute phase, as well as left ventricular and atrial longitudinal strain on admission, at discharge, and after 3 months.MethodsWe performed a single-center prospective cohort study and case–control study. Between September 2020 and February 2022, we enrolled 39 patients hospitalized for MIS-C at our center. We performed left ventricular and atrial longitudinal 2D strain analysis on admission and during follow-up; echocardiographic data were compared to a matched control population. Patients above 4 years old with increased troponin underwent CMR.ResultsOf 24 patients (mean age: 8.2 ± 4.9 years) who underwent CMR, 14 (58%) presented myocardial edema and 6 (25%) late gadolinium enhancement (LGE). LGE was associated with older age (p &lt; 0.01), increased BMI (p = 0.03), increased ferritin levels (p &lt; 0.001), lower left ventricular (LV) ejection fraction (p &lt; 0.001), LV longitudinal strain (p = 0.004), left atrial (LA) strain (p = 0.05), and prolonged hospital stay (p = 0.02). On admission, LV ejection fraction, LV longitudinal strain, and LA strain were impaired, but each improved gradually over time; LVEF was the fastest to recover, while global LV longitudinal strain was still impaired as compared to controls after 3 months (p = 0.01).ConclusionOur study demonstrates that myocardial injury is present in a quarter of MIS-C patients, and impaired LA and LV myocardial deformation persist for at least several weeks after the acute phase. CMR and LV/LA strain could help us to individualize follow-up of MIS-C patients.
Multislice computerized tomography coronary angiography can be a comparable tool to intravascular ultrasound in evaluating “true” coronary artery bifurcations
Authors: Radunović Anja , Vidaković Radosav , Timčić Stefan , Odanović Natalija , Stefanović Milica , Lipovac Mirko , Krupniković Kosta , Mandić Aleksandar , Kojić Dejan , Tomović Milosav , Ilić Ivan 
Published: November 2023

AimCoronary bifurcation atherosclerosis depends on its angles, flow, and extensive branching. We investigate the ability of CT coronary angiography (CTCA) to determine atherosclerotic plaque characteristics of “true” bifurcation compared with intravascular ultrasound (IVUS) and the influence on side branch (SB) fate after percutaneous coronary intervention (PCI).Methods and resultsThe study included 70 patients with 72 “true” bifurcations. Most of the bifurcations were in the left anterior descending—diagonal (Dg) territory [50 out of 72 (69.4%)]. Longitudinal plaque evaluation at the polygon of confluence [carina and 5 mm proximal and distal in the main branch (MB)] showed that carina side MB and SB plaque had occurred with the lowest incidence with fibro-lipid structure (115 ± 63 HU and 89 ± 73 HU, p &lt; 0.001 for all). Bland–Altman analysis showed a discrepancy in measuring mainly the lumen area between CTCA and IVUS in proximal MB [lumen 5.10, 95% CI (95% confidence interval, 4.53–5.68) mm2, p &lt; 0.001; vessel −1.42, 95% CI (−2.63 to −0.21) mm2, p = 0.023], carina MB [lumen 3.74, 95% CI (3.37–4.10) mm2, p &lt; 0.001; vessel −0.48, 95% CI (−1.45 to 0.48) mm2, p = 0.322], and distal MB [lumen 4.72, 95% CI (4.27–5.18) mm2, p &lt; 0.001; vessel 0.62, 95% CI (−0.53 to 1.77) mm2, p = 0.283]. A significant correlation existed between average plaque density on CTCA with a percentage of calcified plaque on IVUS tissue characterization (proximal r = 0.307/p = 0.024, carina 0.469/0.008, distal 0.339/0.024, minimal lumen diameter 0.318/0.020). Circumferential plaque in the proximal MB segment remained an independent predictor of SB compromise [OR 3.962 (95% CI 1.170–13.418)].ConclusionDetection and characterization of atherosclerotic plaque by CTCA in non-left main “true” coronary bifurcations can provide useful information about bifurcation anatomy and plaque distribution that can predict outcomes after provisional stenting, thus guiding the interventional strategy to bifurcation PCI.
Biodistribution of the saponin-based adjuvant Matrix-M™ following intramuscular injection in mice
Authors: Carnrot Cecilia , Carow Berit , Palm Anna-Karin E. , Akpinar Eray , Helgesson Per-Henrik , Osterman Ingrid Lekberg , Bringeland Emelie , Foreman Bryant , Patel Nita , Bankefors Johan , Fries Louis , Stertman Linda 
Published: November 2023

Novel adjuvants are extensively utilized in the development of safe and effective vaccines against emerging pathogens. Matrix-M™ adjuvant is a saponin-based adjuvant used in several active clinical development programs and in widespread use in the COVID-19 vaccine NVX-CoV2373. Here, we conducted a biodistribution study to better understand the mechanism of action and safety profile for Matrix-M™ adjuvant. Radiolabeled saponins or cholesterol were incorporated into Matrix-A™ particles, which represent 85% of Matrix-M™. Labeled Matrix-M™ adjuvant was given to mice by intramuscular injection with or without SARS-CoV-2 Spike protein. Radioactivity of the adjuvant components was quantified in local and systemic tissues at seven timepoints over a period of 1–168 h. The highest saponin levels were found at the 1-h timepoint at the injection site, in the draining (iliac) lymph nodes, and in urine. Saponins were rapidly cleared from these tissues, reaching very low levels by 48–72 h. Systemically, saponins were found at low levels in the plasma, kidneys, liver, and bone marrow, and were barely detectable in other investigated tissues. Cholesterol was also found at high levels at the injection site and in the draining lymph nodes. These levels declined rapidly at first, then plateaued at 24–48 h. Radiolabeled cholesterol was found at very low levels in other tissues at the earliest timepoints, until increasing and stabilizing after the 24-h timepoint, indicating entry into the endogenous cholesterol recycling pool. This study demonstrates a rapid distribution of Matrix-M™ adjuvant from the injection site to the draining lymph nodes, thus excluding a depot effect as central to the mechanism of action for this adjuvant. The diverging clearance patterns for saponins and cholesterol are suggestive of at least partial disassembly of the Matrix-particles, which has implications for the downstream effects of Matrix-M™ adjuvant on adaptive immune responses. Systemic exposure to toxicologically relevant tissues is very low.
Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer
Authors: Wang YaXuan , Wang Jinfeng , He JiaXing , Ji Bo , Pang ZhongQi , Wang JianShe , Liu Yang , Ren MingHua 
Published: November 2023

BackgroundPre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial role in repairing tumor-damaged cells and promoting cell survival. However, the predictive value and biological function of PRPF19 in bladder urothelial carcinoma (BLCA) require further investigation.MethodsIn this study, we utilized transcriptomic data and bladder cancer tissue microarrays to identify the high expression of PRPF19 in BLCA, suggesting its potential as a prognostic biomarker. To gain a better understanding of the role of PRPF19 in the immune microenvironment of BLCA, we performed single cell analysis and employed the LASSO method. Additionally, we examined the methylation profiles of PRPF19 using the SMART website. Our investigation confirmed the correlation between PRPF19 and BLCA cell senescence and stemness. Furthermore, we constructed a PRPF19-miR-125a-5p-LINC02693-MIR4435-2HG ceRNA network using the ENCORI and miRWALK databases.ResultsOur comprehensive analysis reveals that PRPF19 can serve as a prognostic marker for BLCA and is significantly associated with various immune-infiltrating cells in BLCA. Moreover, our findings suggest that PRPF19 influences cellular senescence through the regulation of stemness. Finally, we developed a ceRNA network that has the potential to predict the prognosis of BLCA patients.ConclusionWe confirmed the prognostic value and multiple biological functions of PRPF19 in BLCA. Furthermore, the specific ceRNA network can be used as a potential therapeutic target for BLCA.
Pharmacokinetics and absorption mechanism of tandospirone citrate
Authors: Li Rong , Chen Yuwen , Jia Mi , Jiang Xuehua , Wang Ling 
Published: November 2023

Tandospirone citrate (TDS) is commonly used for the treatment of patients with generalized anxiety disorder in clinical practice, and several studies are developing new indications for TDS. However, the in vivo processes and absorption properties of TDS have not been systematically investigated. In this work, we conducted a comprehensive investigation using in vivo, in vitro, and ex vivo approaches, involving animal and cellular models, to examine the pharmacokinetic properties and absorption mechanisms of TDS. The results of in vivo studies revealed that the half-life (t1/2) of TDS was 1.380 ± 0.46 h and 1.224 ± 0.39 h following intragastric (i.g.) and intravenous (i.v.) administration of 20 mg/kg TDS, respectively. This indicates that TDS is rapidly eliminated in rats. The area under the curve (AUC) of TDS after i.g. and i.v. administration was 114.7 ± 40 ng/mL*h and 48,400 ± 19,110 ng/mL*h, respectively, and the absolute bioavailability of TDS was found to be low (0.24%). Furthermore, TDS was extensively metabolized in rats, with the AUC of the major active metabolite [1-[2-pyrimidyl]-piperazine] being approximately 16.38-fold higher than that of TDS after i.g. administration. The results from the in vitro Caco-2 cell model and ex vivo everted gut sac experiment demonstrated that TDS exhibited good permeability, and its transport was influenced by concentration, temperature, and pH. Passive diffusion was identified as the main absorption mechanism. In conclusion, TDS is classified as a Biopharmaceutics Classification System (BCS) class I drug, characterized by high solubility and permeability. The low absolute bioavailability of TDS may be attributed to its rapid metabolism. The pharmacokinetic data and absorption characteristics obtained in this study provide fundamental information for the further development and utilization of TDS.
Parameter optimization of the spiral fertiliser discharger for mango orchards based on the discrete element method and genetic algorithm
Authors: Zhao Liang , Zhou Hongping , Xu Linyun , Yuan Weidong , Shi Minghong , Zhang Jian , Xue Zhong 
Published: November 2023

IntroductionIn order to solve the problems of inaccurate fertilization, unstable fertilization and low fertiliserutilization rate in mango orchard.MethodsA small spiral fertiliser discharger was designed based on the agronomic characteristics of fertilization in mango orchard. The fertilizing performance test and parameter optimization of thespiral fertiliser discharger were carried out by combining bench and simulation test. Firstly, the main influencing factors of the fertilizing performance of the spiral fertiliser discharger were analyzed by theoretical calculation formula, and the range of its value was preliminarily determined. At the same time, the digital and discrete element models of the spiral fertiliser discharger were established. Then,the discrete element model of granular fertiliser was established on the basis of the physical and related mechanical simulation parameters of granular fertiliser obtained by experimental statistics.Taking the variable coefficient of fertilizing stability as the response value, the method of singlefactor simulation fertilizing test was used to explore the parameters that have a significant influence on the variable coefficient of fertilizing stability. The response surface method (RSM) was used tosimulate the fertilizing performance of three significant parameters. Based on the quadraticregression orthogonal rotation combination design test, a second-order regression mathematicalmodel between the variable coefficient of fertilizing stability and the significant parameters wasestablished. The variable coefficient of fertilizing stability was as small as possible. The geneticalgorithm (GA) was used to optimize the regression model. Finally, the verification test of thefluidity and applicability of different fertilisers was carried out. ResultsThe results of single factor test showed that the diameter of spiral blade, pitch and rotationalspeed of fertilizing shaft have significant influence on the variable coefficient of fertilizing stability.The optimal parameter combination of the spiral fertiliser discharger was obtained: 98.44 mm for thediameter of spiral blade, 54.8 mm for the pitch, and 24.43 r/min for the rotational speed of fertilizingshaft. The verification results showed that the average relative error of the test was small, and themass flow rate of different fertilisers and the variable coefficient of fertilizing stability could meetthe agronomic requirements of fertilization in mango orchards. The reliability of the discrete elementsimulation test results and research methods of the spiral fertiliser discharger was verified. ConclusionThe results and methods of this study can provide reference for the development of mangoorchard fertilization machinery and related fertilizing performance test.
The impact of adult children’s support on the psychological health of rural older adult people in China
Authors: Luo Juan , Ji Minglu , Li Mengyuan , Wang Anning 
Published: November 2023

BackgroundFamily old-age care is dominant in Chinese rural society, and children’s support is an important force in family old-age care. However, the migration of a large number of young and middle-aged rural laborers has undermined the traditional arrangements for old-age care in rural areas and affected the psychological health of the older adult.Methods2014 China Longitudinal Aging Social Survey targets Chinese citizens aged 60 or older and covers 28 provinces in mainland China. In this paper, the database of the CLASS was selected for empirical analysis to explore the impact of children’s support on the depression level and loneliness of rural older adults through multiple linear regression, and was divided into two groups according to children’s migration to analyze heterogeneity.ResultsChildren’s financial support facilitates the maintenance of mental health among rural older adults. Children’s support promotes mental health among rural older adults, but this association does not exist among older adults without children’s migration. Individual characteristics of older people have a greater impact on mental health.DiscussionOur study firstly compares the differences of children’s migration status between children’s support and mental health among the older adult in rural China. In order to improve the mental health of the older adult, it is necessary to create a favorable atmosphere of love and respect for the older adult, improve the social security system in rural areas, and give full play to the strengths of the social forces, so as to ensure that the older adult have a sense of worthiness and enjoyment in their old age.
Designing the Classic Teaching Session for Architectural Student via New BOPPPS Model with the Spirit “S” or Seventh Seal
Authors: Gunerathne Ravindra , Marikar Faiz 
Published: November 2023

Purpose is to analyze BOPPPS as a model for participatory learning and development (PLD) activities for architectural students.
Methodology. The methods of analysis, classification, and descriptions are used.
Results. BOPPPS model consists of the following components: Bridge-in: An opening session to introduce the topic, participants, and objectives of the PLD activity. Objectives: Defining the specific goals and outcomes that the PLD activity aims to achieve. Post-test: An evaluation tool used to assess participants' knowledge and understanding of the topic prior to the PLD activity. Participatory Learning: A process where participants actively engage in learning activities, such as group discussions, role-plays, and hands-on exercises, to acquire new knowledge and skills. Post-assessment: An evaluation tool used to assess participants' knowledge and understanding of the topic after the PLD activity. Summary: A closing session where the facilitator summarizes the key takeaways from the PLD activity and highlights areas for further improvement or follow-up. The BOPPPS model is designed to ensure that PLD activities are well-structured, participatory, and effective in promoting learning and development. By incorporating evaluation tools such as pre- and post-tests, the model allows organizers to measure the impact of the PLD activity and assess its effectiveness. The addition of the "S for Spirit" in the BOPPPS model emphasizes the importance of designing PLD activities with the spirit, or the essence and guiding principle, of the project. This means that the PLD activity is not only structured and evaluated effectively, but also aligns with the purpose, values, and vision of the project. Designing with the spirit can add a more meaningful and personal touch to the PLD activity, creating a more impactful learning experience for participants.
Conclusions. The updated BOPPPS model could include one more component Spirit (S). They are as followings: Bridge-in, Objectives, Post-test, Participatory Learning, Post-assessment, Summary, and definitely Spirit (S) – the guiding principle and essence of the project that shapes the PLD activity.
Hydrocarbon charge and petroleum system evolution of the Montney Formation: A multidisciplinary case study of the Blueberry sub-play in Northeast British Columbia, Canada
Authors: Watt Elizabeth A. , Laycock Dallin P. , Michael Eric , Tobin Rick C. , Kelly Shaina , Johnston Michelle N. 
Published: November 2023

Abstract
The origin, timing, and evolution of hydrocarbons in the early Triassic Montney Formation siltstone has long been debated and is poorly understood. A proper understanding of the timing and processes involved in hydrocarbon emplacement forms an important part of in-situ fluid characterization. Presented here is a case study from northeastern British Columbia. This study integrates basin modeling, carbon isotope geochemistry, fluid inclusion microthermometry, organic and inorganic petrography, sedimentology, and stratigraphy to reconstruct the burial history and relative timing of geological events and mechanisms involved in developing the present-day Montney hydrocarbon system in the Blueberry sub-play.
Petrography from whole core indicates that the organic material present is largely pyrobitumen. The lack of primary kerogen suggests that the original oil charge must have migrated into place prior to increasing thermal maturity and conversion to pyrobitumen at maximum burial. In addition, patterns in stable carbon isotope curves from extracted core fluids show a stratified oil column, indicating a lack of vertical migration that would have homogenized the hydrocarbons. Thin section petrography and facies analysis show a laminated fabric with strong permeability anisotropy suggesting preferential migration along bed-parallel permeability pathways, which would have prevented significant vertical mixing. Any interpretations about the origins of the Montney Formation hydrocarbons in this study area must satisfy these observations. Given the data available, the most likely interpretation is a bed-parallel eastern migration from a downdip source.
Collective understanding of these datasets helps illustrate the processes involved in the evolution of the hydrocarbon system present in the Montney Formation. Enhanced understanding of the Montney hydrocarbon migration history and reservoir evolution is important for understanding the lateral and vertical variations in the producing gas-condensate-ratios across the Montney formation fairway.