bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of resuscitative endovascular balloon occlusion of the aorta on gastrointestinal function with a matched cohort study
Authors: Matsumoto Shokei , Aoki Makoto , Funabiki Tomohiro , Shimizu Masayuki 
Published: January 2024

BackgroundResuscitative endovascular balloon occlusion of the aorta (REBOA) can temporarily control arterial hemorrhage in torso trauma; however, the abdominal visceral blood flow is also blocked by REBOA. The aim of this study was to evaluate the influence of REBOA on gastrointestinal function.MethodsA retrospective review identified all trauma patients admitted to our trauma center between 2008 and 2019. We used propensity score matching analysis to compare the gastrointestinal function between subjects who underwent REBOA and those who did not. Data on demographics, feeding intolerance (FI), time to feeding goal achievement, and complications were retrieved.ResultsDuring the study period, 55 patients underwent REBOA. A total of 1694 patients met the inclusion criteria, 27 of whom were a subset of those who underwent REBOA. After 1:1 propensity score matching, the REBOA and no-REBOA groups were assigned 22 patients each. Patients in the REBOA group had a significantly higher incidence of FI (77% vs. 27%; OR, 9.1; 95% CI, 2.31 to 35.7; p=0.002) and longer time to feeding goal achievement (8 vs. 6 days, p=0.022) than patients in the no-REBOA group. Patients in the REBOA group also showed significantly prolonged durations of ventilator use (8 vs. 4 days, p=0.023). Furthermore, there was no difference in the mortality rate between the groups (9% vs. 9%, p=1.000).ConclusionsREBOA was associated with gastrointestinal dysfunction. Our study findings can be useful in providing guidance on managing nutrition in trauma patients who undergo REBOA.Level of evidenceLevel IVStudy typeCare management
Repulsive and attractive response of mature Rattus rattus towards conspecific natural urinary signals of the same and the opposite sex
Authors: Garg Nidhi , Singla Neena , Mahal Amrit Kaur 
Published: January 2024

Abstract
Urinary signals play an important role in communication between the individuals of the same species. The present study observed the response of mature male and female Rattus rattus towards conspecific natural urine of the same and the opposite sex. Responses to urine signals were determined based on food consumption on the treated and untreated sides of the cage. Mature male rats consumed significantly more food when treated with the urine of grouped mature female rats and female rats in the oestrous, pro-oestrous, di-oestrous, metoestrous, and lactation stages, while significantly low food consumption was observed in male rats in response to the urine of individual and grouped mature male rats, indicating strong attraction to the urine of the opposite sex and strong repulsion towards urine of the same sex. Similar observations were confirmed in bi-choice and multichoice maze experiments. Male rats did not show any significant response towards the urine of pregnant females. Under simulated store conditions, repulsion towards urine of the same sex was shown up to six days of exposure while the attraction towards the urine of the opposite sex was shown up to three days of exposure. Under simulated field conditions, the repulsive effect towards urine of the same sex remained for 9-13 days and the attractant effect to the urine of the opposite sex remained for all 15 days of the experiment. The study thus indicates that the reproductive condition of rats influences the communicative signals they produce as well as their own responses to conspecific signals of the same and the opposite sex.
A review of edible insect proteins application: health benefits and safety
Authors: Wang X. , Fu L.J. , Ma J.M. , Li Q. , Sun Y. , Wang Y. , Zhang Y. 
Published: January 2024

Abstract
In recent years, the rapid growth of the global population has led to a serious shortage of food resources, necessitating the exploration and utilization of new resources. Edible insects have gained attention due to their high protein content, similar to that of traditional meat proteins, along with a host of beneficial nutritional and health properties. Besides their wonderful nutritional composition, edible insect proteins also have various health benefits like antioxidation, anti-hypertension, anti-inflammation, antimicrobial activity, and immunoregulation. However, considerations regarding their safety and hygienic characteristics are crucial for their widespread development as a new protein source. Herein, we systematically summarized the nutritional value and functional features of insect protein, additionally, their applications and health benefits were also reviewed. Finally, their safety aspects and prospect of further research were also discussed in order to provide beneficial references for future research.
The Ming Dynasty (1368–1644) and Its Non-Han Military Auxiliaries
Authors: Robinson David 
Published: January 2024

Abstract
War is as much an exercise in building relations as breaking enemies. Relation building inevitably involves transfer—whether it is movement of people, exchange of goods, formation of social ties, or change of identity. This article focuses on efforts by the Ming dynasty (1368–1644) to secure skilled fighters from among populations that it viewed as distinct from the Chinese (or Han) majority but still integral parts of the polity. Contemporaries understood that alliances were indispensable for securing diverse sources of military labor, and they invested considerable political, economic, and cultural capital to build and maintain those relationships. The resulting exchanges, which included people, animals, textiles, gowns, silver, and more, were an essential feature of dynastic rule, a defining element of newly incorporated subjects, and an integral dimension of indigenous power.
Outcomes After Revision Arthroscopic Rotator Cuff Repair: A Systematic Review
Authors: Hurley Eoghan T. , Krez Alexandra N. , Wu Kevin A. , Levin Jay , Crook Bryan S. , Anakwenze Oke A. , Klifto Christopher S. 
Published: January 2024

Background: Arthroscopic rotator cuff repair (ARCR) is one of the most commonly performed orthopaedic procedures; however, it is unclear how to manage patients with symptomatic retears. Purpose: To perform a systematic review to evaluate the outcomes of revision ARCR in the literature. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic literature search based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed utilizing the Embase, MEDLINE, and Cochrane Library databases. Eligible for inclusion were clinical studies reporting on revision rotator cuff repair. Clinical outcomes were recorded. Results: The 17 included studies were composed of 888 shoulders in 885 patients. The mean age of the 885 patients was 58.6 ± 9.1 years, with a mean follow-up of 28.1 ± 22.1 months. The mean visual analog scale score was 2.1 ± 1.8, the mean American Shoulder and Elbow Surgeons score was 75.0 ± 18.3, and the mean Constant score was 67.4 ± 16.6. The overall rate of retears after revision was 25.3%, with an 8.0% reoperation rate including 2.7% undergoing reverse shoulder arthroplasty and 2.0% undergoing subsequent rotator cuff repair. Finally, the complication rate was 8.6%. Conclusion: Revision ARCR improved patient-reported outcomes, with 92% of patients free from reoperations at a mean follow-up of 2 years. Overall, 78.4% of patients were satisfied at final follow-up; however, the rate of retears was found to be higher than after primary ARCR.
Ibudilast reduces slowly enlarging lesions in progressive multiple sclerosis
Authors: Nakamura Kunio , Thoomukuntla Bhaskar , Bena James , Cohen Jeffrey A , Fox Robert J , Ontaneda Daniel 
Published: January 2024

Background: Ibudilast has shown beneficial effects on several imaging outcomes in progressive multiple sclerosis (MS). Slowly enlarging lesions are a proposed imaging biomarker of compartmentalized inflammation within chronic active lesions. Objective: To assess the treatment effect of ibudilast on slowly enlarging lesion volumes over 96 weeks from a phase II clinical trial of ibudilast (Secondary and Primary Progressive Ibudilast NeuroNEXT Trial in Multiple Sclerosis [SPRINT-MS]). Methods: In total, 255 participants with progressive MS from 28 sites were randomized to oral ibudilast or placebo. Participants with at least four analyzable magnetic resonance imaging (MRI) were included. Slowly enlarging lesions were quantified using Jacobian determinant maps. A linear model was used to assess the effect of ibudilast. Magnetization transfer ratio within slowly enlarging lesions was assessed to determine the effect of ibudilast on tissue integrity. Results: In total, 195 participants were included in this analysis. Ibudilast significantly decreased slowly enlarging lesion volume (23%, p = 0.003). Ibudilast also reduced magnetization transfer ratio change in slowly enlarging lesions: 0.22%/year, p = 0.04. Conclusion: Ibudilast showed a significant effect on baseline volume of lesions that were slowly enlarging and magnetization transfer ratio in slowly enlarging lesions. The results support the use of slowly enlarging lesions for assessment of compartmentalized inflammation represented by chronic active lesions and provide further support for the neuroprotective effects of ibudilast in progressive MS.
Risk Prediction of Diabetic Foot Amputation Using Machine Learning and Explainable Artificial Intelligence
Authors: Oei Chien Wei , Chan Yam Meng , Zhang Xiaojin , Leo Kee Hao , Yong Enming , Chong Rhan Chaen , Hong Qiantai , Zhang Li , Pan Ying , Tan Glenn Wei Leong , Mak Malcolm Han Wen 
Published: January 2024

Background:Diabetic foot ulcers (DFUs) are serious complications of diabetes which can lead to lower extremity amputations (LEAs). Risk prediction models can identify high-risk patients who can benefit from early intervention. Machine learning (ML) methods have shown promising utility in medical applications. Explainable modeling can help its integration and acceptance. This study aims to develop a risk prediction model using ML algorithms with explainability for LEA in DFU patients.Methods:This study is a retrospective review of 2559 inpatient DFU episodes in a tertiary institution from 2012 to 2017. Fifty-one features including patient demographics, comorbidities, medication, wound characteristics, and laboratory results were reviewed. Outcome measures were the risk of major LEA, minor LEA and any LEA. Machine learning models were developed for each outcome, with model performance evaluated using receiver operating characteristic (ROC) curves, balanced-accuracy and F1-score. SHapley Additive exPlanations (SHAP) was applied to interpret the model for explainability.Results:Model performance for prediction of major, minor, and any LEA event achieved ROC of 0.820, 0.637, and 0.756, respectively, with XGBoost, XGBoost, and Gradient Boosted Trees algorithms demonstrating best results for each model, respectively. Using SHAP, key features that contributed to the predictions were identified for explainability. Total white cell (TWC) count, comorbidity score and red blood cell count contributed highest weightage to major LEA event. Total white cell, eosinophils, and necrotic eschar in the wound contributed most to any LEA event.Conclusions:Machine learning algorithms performed well in predicting the risk of LEA in a patient with DFU. Explainability can help provide clinical insights and identify at-risk patients for early intervention.
Learning From Experience: Perceptions of Socio-Emotional Development Among German Students During COVID-19
Authors: Crăciun Irina Catrinel 
Published: January 2024

The COVID-19 pandemic had an impact on emerging adults’ life and development. The present study explores the socio-emotional development during the corona pandemic from the perspective of German students themselves. Episodic semi-structured interviews were conducted with 30 students and analysed with thematic coding. The main developmental challenges included missed opportunities and experiencing uncertainty, while family support and an optimistic attitude facilitated socioemotional growth. Social developmental gains included increased social support from family and friends and the formation of a generational social identity. Regarding emotional development, self-reflection and self-confidence were enhanced. Findings can be integrated in the Positive Youth Development Theory, as the socio-emotional gains match the 5 C’s (competence, confidence, connection, caring, character). Results have relevant practical implications concerning how to foster positive youth development during uncertain times.
Advantages of an Image-Guided Subcranial Technique for Le Fort III Osteotomies for Midface Advancement: A Case Series
Authors: Holste Katherine G. , Makar Katelyn G. , Ulma Raquel M. , Garton Hugh J.L. , Buchman Steven R. , Vercler Christian J. , Muraszko Karin M. 
Published: January 2024

Objective: Le Fort III osteotomies are used to advance the midface in children with midface hypoplasia and syndromic craniosynostosis. Complications can occur during the subcranial osteotomies, leading todural violations as well as vascular and neurologic injuries. In patients with cerebrospinal fluid (CSF) shunts, CSF leak places them at risk of shunt infection. To avoid these injuries, surgeons may utilize an intracranial approach to gain optimal visualization of the cranial base for the horizontal cut through the ethmoid bone, at the naso-frontal junction, below the cribiform plate. A formal craniotomy to simply assure a safe osteotomy, however, may well be an unnecessary morbidity. The aim of this study was to describe the indications for and technical advantages of image guidance for subcranial Le Fort III osteotomies without a craniotomy. Methods: We describe the use of the StealthStation 3-D intraoperative image guidance system for subcranial Le Fort III osteotomies and associated clinical outcomes. An electronic medical record search at a single academic institution identified 10 patients with Current Procedural Terminology codes 21154-21155 (reconstruction midface, Le Fort III). Results: Six patients underwent image-guided subcranial Le Fort III osteotomies between 2008 and 2023. There were no cases of vascular injury, cranial nerve injury, or cerebrospinal fluid leak. No patients with a CSF shunt experienced shunt infection during follow up. Conclusions: Image-guidance provides technical advantages as an alternative approach to subcranial Le Fort III osteotomies while allowing the surgeon to avoid the morbidity of a craniotomy.
A real-world analysis of clinical outcomes in AML with myelodysplasia-related changes: a comparison of ICC and WHO-HAEM5 criteria
Authors: Zhou Qianghua , Zhao Davidson , Zarif Mojgan , Davidson Marta B. , Minden Mark D. , Tierens Anne , Yeung Yu Wing Tony , Wei Cuihong , Chang Hong 
Published: January 2024

AbstractThe proposed fifth edition of the World Health Organization classification of hematolymphoid tumors (WHO-HAEM5) and International Consensus Classification (ICC) provide different definitions of acute myeloid leukemia with myelodysplasia-related genetics (AML-MR). We conducted a retrospective study which included a cohort of 432 patients, with 354 patients fulfilling WHO-HAEM5 criteria for WHO-AML-MR or 276 patients fulfilling ICC criteria for ICC-AML-MR by gene mutation or cytogenetics (ICC-AML-MR-M/CG). The clinicopathological features were largely similar, irrespective of the classification used, except for higher rates of complex karyotype, monosomy 17, TP53 mutations, and fewer RUNX1 mutations in the WHO-AML-MR group. TP53 mutations were associated with distinct clinicopathological features and dismal outcomes (hazard ratio [HR], 2.98; P &lt; .001). ICC-AML-MR-M/CG group had superior outcome compared with the WHO-AML-MR group (HR, 0.80, P = .032), largely in part due to defining TP53 mutated AML as a standalone entity. In the intensively-treated group, WHO-AML-MR had significantly worse outcomes than AML by differentiation (HR, 1.97; P = .024). Based on ICC criteria, ICC-AML-MR-M/CG had more inferior outcomes compared to AML not otherwise specified (HR, 2.11; P = .048 and HR, 2.55; P = .028; respectively). Furthermore, changing the order of genetic abnormalities defining AML-MR (ie, by gene mutations or cytogenetics) did not significantly affect clinical outcomes. ICC-AML-MR-M/CG showed similar outcomes regardless of the order of assignment. We propose to harmonize the 2 classifications by excluding TP53 mutations from WHO-HAEM5 defined AML-MR group and combining AML-MR defined by gene mutations and cytogenetics to form a unified group.
Genome-wide association study, population structure, and genetic diversity of the tea plant in Guizhou Plateau
Authors: Wang Yihan , Niu Suzhen , Deng Xinyue , Bai Dingchen , Chen Zhengwu , Deng Xiuling , Huang Dejun 
Published: January 2024

Abstract
Background
Guizhou Plateau, as one of the original centers of tea plant, has a profound multi-ethnic cultural heritage and abundant tea germplasm resources. However, the impact of indigenous community factors on the genetic diversity, population structure and geographical distribution of tea plant is still unclear.

Results
Using the genotyping-by-sequencing (GBS) approach, we collected 415 tea plant accessions from the study sites, estimated genetic diversity, developed a core collection, and conducted a genome-wide association study (GWAS) based on 99,363 high-quality single-nucleotide polymorphisms (SNPs). A total of 415 tea accessions were clustered into six populations (GP01, GP02, GP03, GP04, GP05 and GP06), and the results showed that GP04 and GP05 had the highest and lowest genetic diversity (Pi = 0.214 and Pi = 0.145, respectively). Moreover, 136 tea accessions (33%) were selected to construct the core set that can represent the genetic diversity of the whole collection. By analyzing seven significant SNP markers associated with the traits such as the germination period of one bud and two leaves (OTL) and the germination period of one bud and three leaves (OtL), four candidate genes possibly related to OTL and OtL were identified.

Conclusions
This study revealed the impact of indigenous communities on the population structure of 415 tea accessions, indicating the importance of cultural practices for protection and utilization of tea plant genetic resources. Four potential candidate genes associated with the OTL and OtL of tea plant were also identified, which will facilitate genetic research, germplasm conservation, and breeding.
German translation and validation of the complementary and alternative medicine health belief questionnaire (CHBQ)
Authors: Hinse Maximilian , Jerzynski Lea , Binting Sylvia , Kummer Sonja , Brinkhaus Benno , Rotter Gabriele 
Published: January 2024

AbstractBackgroundThe Complementary and Alternative Health Belief Questionnaire (CHBQ) measures medical students’ attitudes towards Complementary Medicine (CM). The aim of the study was to examine the validity and reliability of the German translation of the CHBQ.MethodsData for the psychometric evaluation of the German translation were drawn from a study that investigated attitudes towards CM in (a sample of) medical students at Charité - Universitätsmedizin Berlin. Construct validity was determined via an exploratory factor analysis (EFA). Internal consistency was examined using Cronbach’s alpha and split-half reliability.ResultsThe CHBQ was returned by 278 students, and was fully completed by 260 students (mean age 23.7 years; ± 4.3 SD), 69.2% were female). EFA revealed a single factor solution for all 10 items of the scale. All items, except one, had good item discrimination (range: 0.5–0.8), acceptable mean inter-item-correlation (0.39) and similar median correlation (0.38). Reliability was very good (α = 0.86) and further confirmed by split-half reliability (0.91).ConclusionsThe German version of the CHBQ is a valid and reliable instrument for measuring students’ attitudes towards CM.
Informed consent practice and associated factors among healthcare professionals in public hospitals of Southern Ethiopia, 2023: a mixed-method study
Authors: Bolado Getachew Nigussie , Ataro Bizuayehu Atnafu , Feleke Mulualem Gete , Gadabo Christian Kebede , Kebamo Tamirat Ersino , Minuta Worku Mimani 
Published: January 2024

Abstract
Background
Patients may sign a consent form before the specific treatment is offered for a variety of reasons, including during an outpatient appointment. Healthcare professionals must obtain consent from patients or other legal persons before providing any treatment or performing any procedures. But, little attention has been given to the informed consent process in Ethiopia.

Objective
To assess informed consent practice and associated factors among healthcare professionals in Wolaita Zone, Southern Ethiopia public hospitals from January, 2023.

Methods
An institutional-based cross-sectional mixed-method study was conducted among 399 healthcare professionals. Simple random sampling and purposive sampling techniques were used to select healthcare professionals for quantitative and qualitative studies respectively. Data for both studies were collected using self-administered questionnaire and key informant interview respectively. EpiDataV4.6 and the Statistical Package for the Social Science was used for entry and analysis of quantitative data. OpenCode software was used for thematic analysis for qualitative data.

Results
339 respondents were included in the study, with a response rate of 94.3%. The good practice of informed consent among the healthcare professionals is 53.1%. There was a significant association between the good practice of informed consent and being male [AOR: 0.003 (95% CI: 0.000–0.017)], working in a comprehensive specialized hospital [AOR: 4.775 (95% CI: 1.45–15.74)] and in-service training [AOR: 0.038 (95% CI: 0.013–0.114)].

Conclusion and recommendations
More than half of healthcare professionals had good practices for informed consent. However, it is critical to plan and intervene various strategies with the goal of improving knowledge and attitude toward informed consent.