bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrepreneurship Education for Prospective Elementary School Teachers in the VUCA Era
Authors: Arifin Muh. Husen 
Published: January 2024

<p>Berwirausaha di era VUCA menjadi tantangan dan peluang yang harus diinterpretasikan dengan baik, utamanya bagi mahasiswa calon guru sekolah dasar. Tujuan dari penelitian ini mengungkap tentang pentingnya mengimplementasikan pendidikan kewirausahaan bagi calon guru sekolah dasar. Metode penelitian menggunakan penelitian kualitatif deskriptif dengan tahapan studi kasus pada 184 mahasiswa calon guru sekolah dasar di PGSD Kampus UPI di Cibiru. Hasil dari penelitian ini mahasiswa calon guru sekolah dasar dapat mengimplementasikan pendidikan kewirausahaan dengan menciptakan produk kreatif. Melalui pengalaman menciptakan produk kreatif tersebut maka calon guru sekolah dasar memiliki karakter berwirausaha yang dapat dikembangkan kelak sehingga bisa menjadi guru yang berwirausaha secara produktif.</p><div id="pip-toast"> </div>
Environmentally Friendly Rosin-Modified Silica Nanocomposite as High-Performance Plugging Agent for Drilling in Nano-Microporous Formations
Authors: Lei Ming , Sun Jinsheng , Huang Weian , Zhu Haiyan 
Published: January 2024

Summary
The increasingly severe wellbore instability problem and the intensified environmental requirements necessitate the development of high-performance and environmentally friendly plugging materials for drilling fluid. In this work, a novel core-shell nanocomposite (PDSA) with nano-silica (nano-SiO2) as the rigid core and hydrophobic resin derived from dehydroabietic acid (DHAA) of pine rosin and crosslinked hydrophilic layer of 2-acrylamido-2-methyl-1-propanesulfonic acid and N, N-dimethylacrylamide (DMA) as the polymer shell was synthesized through semi-continuous emulsion polymerization. The molecular structure of PDSA was confirmed by proton nuclear magnetic resonance and Fourier transform infrared spectra analysis. Particle-size distribution and morphology measured by dynamic light scattering, scanning electron microscopy, and transmission electron microscopy revealed that PDSA was a monodisperse nanosphere with a particle size of around 98 nm, with a core-shell structure and possessed excellent long-term colloidal dispersion stability. The nano-microporous plugging performance of PDSA was evaluated using tight sandstone cores, shale cuttings, and filter membranes (200–400 nm) as plugging media. The results showed that PDSA could form effective aggregated plugging zones in nano-micropores and fractures in sandstone core and shale samples, lowering the core permeability by 78% and improving the shale recovery to above 80%, superior to conventional plugging agents of nano-polyester (NP) and sulfonated asphalt. PDSA also effectively minimized the nano-micropore fluid loss for filter membranes under high-temperature and high-pressure (HTHP) conditions. Furthermore, based on the response surface methodology (RSM) design, the established statistical significant prediction model for HTHP nano-microporous fluid loss indicated the main controlling factor of temperature and its interactive effects with PDSA dosage and membrane size. The high-temperature-induced deformation of PDSA in conjunction with the rigid core was conducive to enhancing and maintaining the HTHP plugging effect within 180°C. The plugging mechanism of PDSA was revealed to be the core-shell synergistic plugging effects of the interparticle bridging and gap filling of the rigid core and the adhesive film forming of the rosin resin shell. The study might provide a novel strategy for preparing high-performance and eco-friendly nano-plugging agents from natural rosin to maintain wellbore stability and relieve environmental pressure, especially for applications in the deep shale and tight formations associated with high-temperature and nano-microporous harsh conditions and the environmentally sensitive areas.
Ethno-dermatological practices among Ao (Naga) tribe in Mokokchung district, Nagaland, India
Authors: Pegu Joynath , Bawri Amal , Baro Daimalu , Imlikumba  , Teron Robindra 
Published: January 2024

Abstract
Background
Skin diseases are among the common problems in the world. For centuries folk medicine and medicinal plants were employed by ethnic communities as medicines. A survey was carried out to document the medicinal plant diversity and folk formulation traditionally practiced by the Ao (Naga) tribe in Mokokchung district, Nagaland, India for the treatment of skin diseases.
Materials and Methods
The survey was carried out from September, 2021 to September, 2023. The information was gathered using a pre-structured questionnaire format. Discussion with the traditional healers was conducted.
Results
A total of 32 plant species belonging to 30 families were documented. Among the 32 plant species, 16 are herbs, 10 are shrubs, 4 are trees, and 2 are climbers. A total of 12 distinct skin disorders are reported commonly occurring among the Ao (Naga) tribes, which are treated traditionally. Among the different plant parts, leaves are most frequently used part for the treatment of various skin diseases followed by roots, latex, fruit, stems, bulbs, rhizomes and seeds. A total of 9 folk formulations that are used for the treatment of skin disease are also documented.
Conclusion
This study documented the traditional knowledge and folk medicine for the treatment of skin disorders, which will be helpful for further investigation in the field of pharmacognosy in the aspect of drug design and development.
Spatial tumor immune microenvironment phenotypes in ovarian cancer
Authors: Gerdtsson Anna , Mateoiu Constantina , Lokhande Lavanya , Diep Lan , Knulst Mattis , Carlsson Elias , Ek Sara , Sundfeldt Karin 
Published: January 2024

Abstract

Immunotherapy has largely failed in ovarian carcinoma (OC), likely due to that the vast tumor heterogeneity and variation in immune response have hampered clinical trial outcomes. Tumor-immune microenvironment (TIME) profiling may aid in stratification of OC tumors for guiding treatment selection. Here, we used Digital Spatial Profiling to characterize regions of spatially distinct TIME phenotypes in OC. Tumors with diffuse immune-infiltration and increased tumor-immune spatial interactions have higher presence of IDO1, PD-L1, PD-1 and Tim-3, while focal immune niches had higher CD163 macrophages and a preliminary worse outcome. Immune exclusion was associated with presence of Tregs and activated fibroblasts. High-grade serous OC showed an overall stronger immune response and presence of multiple targetable checkpoints. Low-grade serous OC was associated with high expression of STING and endometrioid ovarian carcinoma had higher presence of CTLA-4. Mucinous and clear cell OC were dominated by focal immune clusters and immune-excluded regions, with mucinous tumors displaying T-cell rich immune niches, and clear cell tumors an overall low immune activation.
Brain volume changes after MR-guided focused ultrasound thalamotomy in patients with essential tremor and Parkinson’s disease
Authors: Purrer Veronika , Pohl Emily , Borger Valeri , Boecker Henning , Paech Daniel , Sauer Malte , Zülow Stefan , Radbruch Alexander , Wüllner Ullrich , Schmeel Frederic 
Published: January 2024

Abstract
Background Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy is a recently developed technique for treatment of severe tremor syndromes. Less is known about potential cortical and subcortical structural changes after ablation of the ventral intermediate nucleus and how these are potentially related to tremor relief.Methods Using an automated artificial-intelligence based approach, cortical and subcortical brain volume changes were investigated in 49 patients with essential tremor (ET) and 19 patients with tremor-dominant Parkinson’s disease (tdPD) before and six months after MRgFUS. Clinical outcome was assessed using the Clinical Rating Scale for Tremor. To evaluate differences in brain volumes, patients were further categorized into a high and low tremor improvement (TI) group.Results Brain volumes did not differ significantly between ET and tdPD patients at baseline. In both entities, significant volume reductions were found in the thalamus treated with thalamotomy along with volume increases in the occipital lobe contralateral to the MRgFUS lesion. Furthermore, significant differences between high and low TI groups were found in the contralateral occipital lobe in both entities, and in the contralateral caudate nucleus in tdPD patients. A significant volume reduction was found in tdPD patients with high TI in ipsilateral parietal lobe, ipsilateral putamen, and contralateral pallidum.Conclusion Our results indicate that TI achieved by MRgFUS thalamotomy affects a complex basal ganglia-thalamo-visuo-cortical network in patients with ET and tdPD. We identified a consistent spatial pattern of brain volume changes, particularly occipital lobe enlargement contralateral to the thalamotomy side, strongly suggesting possible restorative/reshaping effects after TI.
Optimizing Mechanical Ventilation: Personalizing Mechanical Power to Reduce ICU Mortality - A Retrospective Cohort Study
Authors: Alkhalifah Ahmed , Rumindo Kenny , Brincat Edgar , Blanchard Florian , Helleberg Johan , Clarke David , Popoff Benjamin , Duranteau Olivier , Mohamed Zubair Umer , Senosy Abdelrahman 
Published: January 2024

Abstract
Background
Mechanical ventilation, a crucial intervention for acute respiratory distress syndrome (ARDS), can lead to ventilator-induced lung injury (VILI). This study focuses on individualizing mechanical power (MP) in mechanically ventilated patients to minimize VILI and reduce ICU mortality.
Methods
A retrospective analysis was conducted using the Amsterdam University Medical Centers Database (AmsterdamUMCdb) data. The study included patients aged 18 and older who needed at least 48 hours of pressure-controlled mechanical ventilation. Patients who died or were extubated within 48 hours and those with inadequate data were excluded. Patients were categorized into hypoxemia groups based on their PaO2/FiO2 ratio. MP was calculated using a surrogate formula and normalized to ideal body weight (IBW). Statistical analyses and machine learning models, including logistic regression and random forest, were used to predict ICU mortality and establish safe upper limits for IBW-adjusted MP.
Results
Out of 23,106 admissions, 2,338 met the criteria. Nonsurvivors had a significantly higher time-weighted average MP (TWA-MP) than survivors. Safe upper limits for IBW-adjusted MP varied across hypoxemia groups. The XGBoost model showed the highest predictive accuracy for ICU mortality. An individualization method for mechanical ventilation settings, based on real-time physiological variables, demonstrated reduced predicted mortality in a subset of patients.
Discussion
Elevated TWA-MP is associated with increased ICU mortality, underscoring the need for personalized mechanical ventilation strategies. The study highlights the complexity of VILI and the multifactorial nature of ICU mortality. Further studies to define a safe upper limit for IBW-adjusted MP may help clinicians optimize mechanical ventilation settings and decrease the risk of VILI and mortality.
Conclusions
Despite the fact that the study's retrospective design and reliance on a single-center database may limit the generalizability of findings, this study offers valuable insights into the relationship between mechanical power and ICU mortality, emphasizing the need for individualized mechanical ventilation strategies. The findings suggest a potential for more personalized, data-driven approaches in managing mechanically ventilated patients, which could improve patient outcomes in critical care settings.
Microstructural Changes and the Localised Mechanical and Crack Growth Properties in High and Low Speed FSW of 5182-H111 Alloy
Authors: Bernard Dreyer , Hattingh Danie , Goosen William , James Malcolm , Steuwer Axel , Buslaps Thomas 
Published: January 2024

Abstract
Achieving high speed friction stir welding has proven to be challenging for 5xxx-series alloys, as they experience strain hardening during plastic deformation, which is inherent in the FSW process. An earlier publication has discussed the conditions under which welding speeds of up to 1.5 m/min can be achieved in 5182-H111 alloy [1]. The mechanical performance of high speed friction stir welds in 5182-H111 alloy is both surprisingly good and relatively unexplored. Using plates of this alloy welded at a low linear speed of 0.2 m/min as well as at a high speed of 1.5 m/min, the present work evaluated local mechanical properties (microhardness, yield and tensile strength, and fatigue crack growth), in terms of the variation in local microstructure and residual stress. Microstructural variation was investigated via electron back-scatter diffraction (EBSD) and residual stresses were obtained using synchrotron X-ray diffraction strain scanning. The results obtained explain the increased, but different, yield strengths observed in the stir zone and TMAZ regions of the high speed weld and the crack growth rate thresholds.
Viral load suppression and retention in care among children and adolescents receiving multi-month anti-retroviral therapy refills: a program data review in Uganda.
Authors: Ainembabazi Bridget , Ssebunya Rogers N. , Akobye Winnie , Mugume Alexander , Nahirya-Ntege Patricia , Birungi Denise J. , Maganda Albert K. , Elyanu Peter J. , Kiragga Dithan 
Published: January 2024

Abstract

Background
In July 2022, Uganda’s ministry of Health extended the 2021 WHO guidelines that recommended 3–6 monthly dispensing of antiretroviral therapy (ART) to include all children and adolescents living with HIV (CALHIV). Treatment outcomes following this recommendation have not yet been documented. We compared viral load (VL) suppression and retention in HIV care rates among CALHIV receiving 1, 2–5 and > = 6 monthly ART dispensation in Uganda.
Methods
A cross-sectional study of electronic medical records in 118 health facilities was conducted. Data for CALHIV 10–19 years captured at their most recent five clinic visits as of 15th May 2023 were analysed. Most recent two VL < 1000 copies/ml were used as measures for VL suppression and sustained VL suppression. A client was considered retained in care if they visited the clinic within 28 days from their expected return visit date. We used margins plots and a modified poisson model adjusting for facility level clustering to assess VL suppression and retention across multi-month ART categories.
Results
A total of 2864 CALHIV, 1609 (56.2%) being females and with a median age of 12 years (iqr = 7) were included. Overall suppression and retention rates were 80.4% (2133/2654) and 87.8% (2514/2864) respectively. A significant number had been dispensed ART for ≥ 2 months (50%, 2–5 months and 43.5%, ≥ 6 months). Probability of having a suppressed VL was higher among CALHIV that had received ≥ 6 months and 2–5 months of ART compared to those of 1 month i.e., 83% vs 79% vs 41% respectively. Probability of being retained in care didn’t differ across multi-month ART categories. CALHIV who received ART for 2–5 months and ≥ 6 months compared to 1 month were more likely to have a suppressed VL; (adj.PR = 1.98; 95%CI:1.41, 2.80) and (adj.PR = 2.21; 95% CI:1.59, 3.05) respectively. CALHIV with a Tuberculosis diagnosis history were less likely to have a suppressed VL (adj.PR = 0.73; 95%CI:0.65,0.81), however this was not statistically significantly different between multi-month categories.
Conclusion
CALHIV receiving multi-month ART including 6 months dispensation had better VL suppression rates. Retention rates however didn’t differ by multi-month dispensing categories. We recommend multi-month ART dispensation including more than 6 months among CALHIV irrespective of their age, clinical stage, and history of prior co-morbidities.
Spatial Analysis of Meningococcal C Vaccination Coverage in Children in Brazil Between 2011 and 2021
Authors: Pereira Paula Luciana Gonçalves , Silva Thales Philipe Rodrigues , Gilmar José Coelho , Ferraz Marcela Lencine , Ribeiro Elice Eliane Nobre , Silva Tércia Moreira Ribeiro , Souza Maíza Diniz , Penido Fernanda 
Published: January 2024

Abstract

The objective is to analyze MenC vaccination coverage based on the temporal trend of MenC vaccination coverage over 11 years and its spatial distribution, based on the identification of spatial clusters with a large number of children susceptible to DM. This mixed ecological study was performed with secondary data on MenC vaccination coverage from 2011 to 2021 in Brazil. Descriptive analysis was used to assess annual MenC vaccine coverage based on geographic region and years analyzed. The Prais-Winsten linear regression model was used for trend analysis purposes: MenC vaccination coverage by state and region of Brazil was used as a dependent variable and the years analyzed as an independent variable. Spatial dependence and the incidence of spatial clusters formed by municipalities with high and low MenC vaccination coverage were evaluated using spatial statistical analysis. This study showed a downward trend in MenC vaccination coverage in Brazil, in the five regions and in 20 states, as well as a progressive increase in the number of spatial clusters with low vaccination coverage, mainly in the North and Northeast regions. These findings are expected to influence the formulation of practices, policies, programs and actions based on robust scientific evidence on the development of strategies and interventions for the prevention and health promotion of DM at national and global levels.
Mother adversity and co-residence time impact mother-child similarity in genome-wide and gene-specific methylation profiles
Authors: Labaut-Peñalver Lucia , Lage-Castellanos Agustin , Rodrigo Maria José , Herrero-Roldán Silvia , Mitchell Colter , Fisher Jonah , Leon Inmaculada 
Published: January 2024

Abstract

Background. The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underlying mechanism, have been extensively studied. However, the epigenetic resemblance between mother and child in the context of neglectful caregiving, and whether it may be shaped by the emotional impact of maternal stressful events and the duration of co-residence (indexed by child age), remains unknown. The present study examined mother-child similarity in methylation profiles, considering the potential effect of mother adversity, mother empathy, neglect-control group, child age (an index of years of mother-child co-residence), and mother age. We quantified DNAm in 115 mother-child saliva samples and obtained a methylation similarity index by computing correlation coefficients between methylation profiles within dyads, for the entire epigenome, and five specific genes related to stress and empathy: NR3C1, FKPB5, OXTR, SCL6A4, and BDNF. Results. The methylation profiles of the mother-child familial pairs significantly correlated as compared to mother-child random pairs for the entire epigenome and NR3C1, FKBP5, OXTR and BDNF genes. Next, multiple linear regression models observed associations of mother adversity, child age, and neglect-control group on mother-child methylation similarity, only significant in mother-child familial pairs, after correcting for multiple comparisons. Higher mother adversity was associated with lower mother-child methylation similarity for the epigenome-wide analysis, for the BDNF gene, and in the neglect-control group for the OXTR gene. In turn, being an older child (longer co-residence) was associated with higher mother-child methylation similarity. Conclusions. Mother adversity and co-residence time are modulating factors in the intergenerational methylation process that offer a window into development-dependent adaptations that can be affected by both hereditary and environmental factors, significantly observed only in biological dyads. A twofold implication for child well-being emerges, one is positive in that children of mothers exposed to life adversity or neglect did not necessarily inherit their methylation patterns. The other is worrisome, since the time living together is a crucial environmental factor with a high impact on epigenetic transmission in children, reinforcing the need for “the earlier, the better” recommendation of the Child Protection System, which is not always followed.
A Case Report of Post Cesarean Section Vesico-Uterine Fistula (Youssef’s Syndrome) and Review of the Literatures
Authors: Lake Belaynew Keleb , Heyi Getu Dinku , Tsega Kassahun Alamrew , Workneh Meseret Ahunem , Ayicheh Aklilu Tesega , Workineh Zelalem Ayichew 
Published: January 2024

Abstract

Background: - Vesico-uterine fistula is one of the rare types of urogenital fistula that accounts for only 1-4%. Repeat cesarean section is a known cause of vesico uterine fistula. Patients with Youssef's syndrome had a classic triad of absence of incontinence, amenorrhea, and cyclic hematuria.
Case presentation: - A case of surgically managed post-cesarean section vesico-uterine fistula (Youssef's syndrome) patient after she presented with triads of cyclic hematuria, amenorrhea, and absence of urinary incontinence of 4 years duration which had managed by laparotomy with repair of fistulous tracts.
Conclusion: - Patients with Youssef's syndrome can present at any time following cesarean section, and diagnosis needs a high index of suspicion. Surgical repair of the fistulous tract is the mainstay of management.
Do diesel exhaust particles in pollen affect colony founding in the bumblebee B. terrestris?
Authors: Seidenath Dimitri , Mittereder Andreas , Hillenbrand Thomas , Brüggemann Dieter , Otti Oliver , Feldhaar Heike 
Published: January 2024

Abstract

The global insect decline threatens ecosystem functioning because insects provide many essential services, such as pollination or nutrient cycling. Pollution is one of the main drivers of insect decline besides land-use change, global warming, and invasive species. Airborne particulate matter, such as diesel exhaust particles (DEPs), is ubiquitous in the environment. Their effects on insects are still largely unknown. We provided queens and workers of the bumblebee Bombus terrestris with DEP-spiked pollen at the early colony founding stage and compared the colony development to control colonies. After ten weeks, we investigated individual and colony-level life history traits. We did not see any effects of DEP-spiked pollen on worker count, brood count, worker size and relative fat body weight. These results indicate no harmful effects of DEP on colony founding in B. terrestris in our single-stressor setup. Our novel approach adds to the understanding of the role that airborne particulate matter plays in the global insect decline and we are looking forward to seeing similar studies with other species and additional stressors, such as heat stress or food shortages.