bluuebunny/crossref_metadata_2025_split huggingface dataset:
The double-edged sword effect of workplace loneliness on innovative behavior: a perspective grounded in theory on contingencies of self-worth
Authors: Hu Weimin , He Bin , Sun Xu , Zhao Nan 
Published: February 2025

PurposeThe purpose of the study was to investigate both the positive and negative effects of workplace loneliness on innovative behavior. By applying the unified theory on contingencies of self-worth, the study aimed to integrate these effects into a single framework, thereby confirming the presence of the double-edged sword effect of workplace loneliness on innovative behavior.Design/methodology/approachA survey was conducted among enterprises across China, involving 246 employees. Hierarchical regression analysis was utilized to test the moderating hypotheses. Additionally, the mediating effects and the moderated mediation effects were further explored using the bootstrapping method.FindingsThe results indicated that workplace loneliness positively influenced innovative behavior through the desire to prove ability, with the promotion regulatory focus enhancing this relationship. Conversely, workplace loneliness negatively influenced innovative behavior through self-handicapping, with the prevention regulatory focus intensifying this relationship.Practical implicationsThe findings revealed that workplace loneliness exerts a double-edged effect on innovative behavior. Lonely employees can enhance their sense of self-worth by engaging in domain switching, thereby alleviating feelings of loneliness.Originality/valueThe research confirmed a novel perspective: workplace loneliness can promote innovative behavior by influencing employees’ desire to prove ability. It also revealed the double-edged sword effect of workplace loneliness on innovative behavior. Based on these findings, employees experiencing loneliness can enhance their self-worth and alleviate feelings of loneliness through domain switching.
Unveiling the impact of ChatGPT: investigating self-efficacy, anxiety and motivation on student performance in blended learning environments
Authors: Mahande Ridwan Daud , Fakhri M. Miftach , Suwahyu Irwansyah , Sulaiman Dwi Rezky Anandari 
Published: February 2025

PurposeThis study aimed to investigate the impact of ChatGPT on students’ self-efficacy, anxiety and motivation within blended learning environments.Design/methodology/approachA correlational quantitative method was employed using the data collected through an online questionnaire distributed randomly to 293 science and engineering students from 2 state universities in South Sulawesi, Indonesia. Measurement analysis was conducted to assess instrument validity, and structural equation modeling (SEM) was used to examine the relationships between the constructs.FindingsThe results indicate that self-efficacy and motivation significantly enhance student performance in blended learning, with the positive effect of self-efficacy moderated by ChatGPT. Although anxiety had a positive, though not significant, effect, the interaction between anxiety, motivation and ChatGPT still demonstrated a positive effect on learning performance.Research limitations/implicationsThis study highlights the moderating effect of ChatGPT on motivation, anxiety and performance, emphasizing the need to understand educational contexts and individual differences. The study was limited to a specific student population and a short duration of ChatGPT usage, potentially restricting generalizability. Future research should explore diverse educational settings, disciplines, long-term effects and qualitative methods to gain deeper insights.Originality/valueThis study provides valuable new insights into the use of AI technology in education from the psychological perspective of students and offers practical implications for improving future learning strategies.
How and when paternalistic leadership influences service innovative behaviour while inhibiting counterproductive work behaviour among healthcare professionals: the roles of perceived supervisor support and public service motivation
Authors: Hussain Muzammil , Luu Trong Tuan , Marjoribanks Timothy 
Published: February 2025

PurposeHealthcare is a service industry where fulfilling the needs of patients (customers) is challenging. Various factors, including cost, system complexity, staffing behaviours and technological advances, play vital roles. Drawing upon social exchange theory, this study seeks to determine how paternalistic leadership (authoritarianism, benevolence and morality) influences employee service innovative behaviour and counterproductive work behaviour via perceived supervisor support in the healthcare sector. Additionally, the study investigates the role of the public service motivation of individuals as a moderating factor in this relationship.Design/methodology/approachA pilot study and a main study were conducted to test the hypotheses. We collected data from healthcare professionals in Pakistan’s large public, private and semi-government hospitals. We applied bootstrapping with 5,000 replications and structural equation modelling to analyse the data.FindingsResults indicate that authoritarianism was negatively associated with service innovative behaviour, whereas benevolent and moral behaviours were positively associated with service innovative behaviour via perceived supervisor support (mediation). Our findings shed light on the moderating role of public service motivation.Originality/valueThis empirical quantitative study has several theoretical and practical implications. Findings of our study provide evidence that a paternalistic leadership style can influence both positive (service innovative behaviour) and negative (counterproductive working behaviour) working behaviours simultaneously via perceived supervisor support at an individual level in the service (healthcare) industry. This study also highlights the moderating role of public service motivation as an individual motivation factor.
Associations of chronic kidney disease with hidradenitis suppurativa: A bidirectional Mendelian randomization study
Authors: Xu Yang , Yang Yiling , Zhan Weisheng , Zhao Juhua 
Published: February 2025

AbstractObservational studies have indicated an association between chronic kidney disease (CKD) and hidradenitis suppurativa (HS). Nevertheless, causality remains unclear. Bidirectional Mendelian randomization (MR) analyses were conducted to investigate the direction of association between CKD and HS. The inverse variance weighting analysis of random effects was used as the primary analytical method and verified through sensitivity analyses. The MR analysis revealed that CKD is associated with an increased risk of HS (odds ratio = 1.577 [95% confidence interval = 1.065–2.337], p = 0.023), and estimated glomerular filtration rate does not increase the risk of HS. In addition, reverse MR analyses revealed no significant associations between HS and CKD. This study provides evidence that CKD is a significant risk factor for HS. However, further research is needed to explore the association between CKD and HS.
Time and matrix quality increase the relative habitat value of smaller patches in fragmented landscapes
Authors: Deane David C. , Riva Federico 
Published: February 2025

Abstract

The landscape‐scale impacts of habitat subdivision (fragmentation per se) on biodiversity are not fully resolved. While smaller patches usually contain more species for equal total area, many implications of this remain unclear. For example, do equal areas of smaller and larger patches provide equivalent habitat value? How might this change over time and under differing matrix conditions?

To help address these knowledge gaps, we developed an indicator of relative habitat value based on a species‐individual null model. We used the indicator to compare sets of patches ordered in small‐to‐large and large‐to‐small orders, building hierarchical Bayesian regression models to test the role of time since patch creation and contrasting matrix conditions. This allowed us to assess habitat value for 85 metacommunities inhabiting fragmented landscapes (1354 patches, >4500 species). We expected comparable habitat value following patch creation due to unpaid extinction debts, and the matrix would determine the direction of change over time, a harsher matrix increasing the relative value of larger patches.

Averaged over time and matrix quality, the indicator probability density was mostly negative, suggesting slightly greater habitat value among larger patches. This pattern was consistent across taxonomic groups, although amphibians and reptiles were the most affected, and invertebrates least so.

Larger patches were of greater value within 20 years of patch creation, but over time smaller patches increased in value under any matrix type, whereas value remained constant for larger patches. Matrix conditions mediated the relative difference: after 100 years under a light matrix, patches of all sizes were essentially of equivalent value, while larger patches were still favoured under a harsh matrix.

Policy implications. In long‐fragmented, light matrix landscapes, small and large patches apparently offer comparable per‐unit‐area habitat value. Conversely, under a harsh matrix, larger patches retain slightly greater habitat value. We speculate that this reflects a ‘colonization credit’, which might occur within smaller patches after the initial loss of fragmentation‐sensitive species in disturbed landscapes. Overall, analyses support the need to maintain and enhance total habitat area—regardless of configuration—for biodiversity conservation, especially in long‐fragmented landscapes with light matrices.
Superior Resolution Profiling of the Coleofasciculus Microbiome by Amplicon Sequencing of the Complete 16S rRNA Gene and ITS Region
Authors: Marter Pia , Freese Heike M. , Ringel Victoria , Brinkmann Henner , Pradella Silke , Rohde Manfred , Jarek Michal , Spröer Cathrin , Wagner‐Döbler Irene , Overmann Jörg , Bunk Boyke , Petersen Jörn 
Published: February 2025

ABSTRACTThe filamentous cyanobacterium Coleofasciculus chthonoplastes is the key primary producer of marine microbial mats. We elucidated the microbiomes of 32 non‐axenic Coleofasciculus isolates using PacBio‐based amplicon sequencing of the complete 16S rRNA gene and the internally transcribed spacer (16S‐ITS). The length of authentic amplicon sequence variants (ASVs) ranged from 1827 to 3044 nucleotides (median: 2267 nt). The results, which were complemented by metagenome analyses and cultivation approaches, revealed the presence of more than 70 associated heterotrophs in the culture of Coleofasciculus sp. WW12. The great bacterial diversity in the cyanosphere is dominated by Pseudomonadota (59%) and Bacteroidota (23%). Allelic ribosomal operon variants were detected in 18 Coleofasciculus strains and our analyses proposed the presence of at least four different species. A comparative analysis of cyanobacterial microbiomes documented complementary advantages of amplicon sequencing versus metagenomics with an individual strength of the 16S‐ITS approach in terms of (i) ribosomal target sequence quality, (ii) contaminant detection and (iii) identification of rare bacteria. The characterisation of the Coleofasciculus microbiome showed that long‐read amplicon sequencing of the 16S‐ITS region is the method of choice for rapid profiling of non‐axenic cyanobacteria. Its superior resolution allows a reliable differentiation of even very closely related strains.
Urological complications following pelvic exenteration are comparable to those following radical cystectomy
Authors: Noll Darcy , Milton Thomas , Vather Ryash , Cho Jonathan , Sammour Tarik 
Published: February 2025

AbstractIntroductionRadical cystectomy and urinary diversion is required for both primary muscle‐invasive bladder cancer and in the setting of pelvic exenteration for advanced malignancy of pelvic organs. Acute and chronic complications following radical cystectomy can be a significant cause of morbidity. We compared the rates of urological complications following these two procedures at our tertiary referral centre.MethodsPatients who underwent radical cystectomy and urinary diversion either alone or as part of pelvic exenteration between June 2017 and April 2024 at our hospital were included. Short and long‐term post‐operative urological complications were collected, and data for patients who underwent PE were collected prospectively as part of a larger database.ResultsOne hundred eleven patients underwent cystectomy: 44 as part of pelvic exenteration (PE), 67 cystectomy alone. Post‐operative urological complications occurred in 45% of patients undergoing PE and 42% undergoing cystectomy alone (P = 0.703). Urosepsis was the most frequent complication in both cohorts, occurring in 27% and 24% of patients who underwent PE and cystectomy alone respectively. Return to theatre was required in 9% of PE patients and 7% of non‐PE patients. ASA status was predictive of complication development in the non‐PE cohort, no factors analysed were predictive in the PE cohort.ConclusionsIn this cohort, the rate of urological complications and return to the theatre following radical cystectomy and urinary diversion were comparable among those undergoing PE and cystectomy alone. No individual factor was identified that was predictive of post‐operative complications.
Atrial and Ventricular Cannulation for Biventricular Circulatory Support With Double‐Ended Centrifugal Pump: In Vitro Evaluation
Authors: Flick Christine R. , Miyagi Chihiro , Kuban Barry D. , Polakowski Anthony R. , Fukamachi Kiyotaka , Kuroda Taiyo , Karimov Jamshid H. 
Published: February 2025

ABSTRACTBackgroundIn patients with biventricular heart failure, a biventricular assist device (BVAD) may be necessary for hemodynamic support. BVAD inflows can be established through cannulation of the atrial (AC) and/or ventricular (VC) chambers, but no consensus exists on optimal cannulation techniques. This study aimed to characterize BVAD performance related to cannulation types (AC and VC) using a continuous‐flow total artificial heart (CFTAH) as the BVAD.MethodsBoth methods of cannulation (AC and VC) were tested on a mock loop using dual pulsatile ventricles with valves (AB5000; Abiomed) paired as the native ventricles and a double‐ended centrifugal pump with two volutes, CFTAH, as a BVAD. Pressures were collected at the inlet and outlets of the AB5000 (LAP, RAP, AoP, and PAP) and the CFTAH (Lin, Rin, Lout, and Rout). The left and right flows exiting the CFTAH (LPF and RPF) and total flow (TF), exiting systemic resistance, were monitored. Several heart failure conditions were simulated with adjustment of the pneumatic pressures (AB5000).ResultsTrends between the AC and VC are similar where RAP, Lin, and Lout decreased, and AoP, PAP, TF, LPF, and RPF increased with increased support. The trends differ in LAP with an increase during AC as opposed to a decrease during VC. As a result, with this setup, left–right balance is more easily achieved during VC. TF is higher with AC, even though LPF and RPF are lower. This signifies the flow going through the aortic valve (TF–LPF) and pulmonary valve (TF–RPF) is higher with AC.ConclusionsThe increased TF and valvular flow favored AC for introducing a CFTAH as BVAD to the native heart in these conditions.
Treatment of Transient Hypothyroxinemia of Prematurity Does Not Improve Neurodevelopment at Two Years of Age
Authors: Bardet Angélique , Vincent Marine , Portefaix Aurélie , Claris Olivier , Butin Marine , Patural Hugues , Picaud Jean‐Charles , Chevallier Marie , Perge Kevin , Raverot Véronique , Riche Benjamin , Bretones Patricia 
Published: February 2025

ABSTRACTAimTransient hypothyroxinemia of prematurity (THOP) has been associated with suboptimal neurodevelopment. We aimed to assess neurodevelopment in very preterm infants with treated and untreated THOP.MethodsThis study was a multicentre, cohort study, based on prospectively collected data in four French level III neonatal intensive care units. Infants born before 32 weeks of gestation between 2009 and 2020 who underwent a thyroid function test were included. THOP was defined as low free thyroxine and unelevated thyroid stimulating hormone. Infants were classified as no THOP, treated THOP, and untreated THOP. The primary outcome was suboptimal neurodevelopment at 2 years of age evaluated by clinical examination.ResultsThree hundred and seventy‐three infants (54% male) born at a median gestational age of 28 weeks of gestation were included. There was no significant difference in neurodevelopment at 2 years of age when comparing the no THOP to the THOP group (Odds Ratio (OR) 1.4, 95% confident Interval (CI) 0.8–2.3) nor when comparing the treated with the untreated THOP group (OR 0.8, 95% CI 0.3–1.9). Results remained unchanged after adjusting for confounding factors.ConclusionIn very preterm infants treated THOP was not associated with improved neurodevelopment compared to untreated THOP. Numerous biases could have limited treatment effect.
Impact of GLP‐1 Receptor Agonists on Alcohol‐Related Liver Disease Development and Progression in Alcohol Use Disorder
Authors: Kuo Chia‐Chih , Li Chun‐Hsien , Chuang Min‐Hsiang , Huang Po‐Yu , Kuo Hsing‐Tao , Lai Chih‐Cheng 
Published: February 2025

ABSTRACTBackground and AimsGlucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have shown promise in reducing alcohol consumption, but their impact on clinical outcomes in patients with alcohol use disorder (AUD) remains unclear. We investigated the association between GLP‐1RAs and the development and progression of alcohol‐related liver disease (ArLD) in patients with AUD.MethodsUsing the TriNetX Research Network, we conducted two retrospective cohort studies comparing GLP‐1RAs versus dipeptidyl peptidase‐4 inhibitors (DPP‐4is) in patients with type 2 diabetes. The first cohort included patients with AUD but without ArLD (n = 7132 after propensity score matching), while the second comprised patients with established ArLD (n = 1896 after matching). Primary outcomes were incident ArLD in the AUD cohort and hepatic decompensation in the ArLD cohort.ResultsIn the AUD cohort (median follow‐up: 63.2 months), GLP‐1RA users showed significantly lower risks of developing ArLD compared to DPP‐4i users (incidence rate: 6.0 vs. 8.7 per 1000 person‐years; HR: 0.62, 95% CI: 0.44–0.87, p = 0.006). GLP‐1RAs were also associated with reduced risks of all‐cause mortality (HR: 0.53, p < 0.001). In the ArLD cohort (median follow‐up: 28.2 months), GLP‐1RA users demonstrated lower risks of hepatic decompensation (incidence rate: 39.5 vs. 51.4 per 1000 person‐years; HR: 0.66, 95% CI: 0.51–0.85, p = 0.001) and all‐cause mortality (HR: 0.53, p < 0.001) compared to DPP‐4i users.ConclusionsGLP‐1RAs were associated with reduced risks of developing and progressing ArLD in patients with AUD, suggesting potential therapeutic benefits in this population.
Concomitant use of clopidogrel and proton pump inhibitors: A retrospective analysis of prescription behaviour
Authors: Wilkes Sarah , van de Wiel Kayleigh , Mulder Kelly , van Ballegooijen Hanne , Zaal Rianne , van der Kuy Hugo 
Published: February 2025

AbstractAimsSince omeprazole and esomeprazole reduce the effect of clopidogrel on the inhibition of platelet aggregation, concomitant use of these drugs has been discouraged by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) since 2010. Currently, it is unknown how often this undesired drug–drug combination is prescribed. The aim of this article is to determine the proportion of patients using omeprazole or esomeprazole among patients using clopidogrel with gastroprotective drugs and to identify differences between these two groups with regard to patient characteristics and prescriber characteristics.MethodsThis was a retrospective analysis of Dutch outpatient medication prescription records between 2015 and 2022. The database had a coverage of approximately 62% of all outpatient prescriptions dispensed in The Netherlands.ResultsThe proportion of patients using omeprazole or esomeprazole as gastroprotective drug in combination with clopidogrel declined from 19.7% to 8.7% between 2015 and 2022. The undesired drug–drug combination was more often prescribed by internists, to women and to patients with polypharmacy (using >10 drugs).ConclusionsAlthough the proportion of patients using clopidogrel together with omeprazole or esomeprazole declined between 2015 and 2022, the undesired combination is still frequently prescribed in The Netherlands. Education about this drug–drug interaction for pharmacists and prescribers is needed since pharmacotherapeutic alternatives are available.
Fluvoxamine Inhibited NLRP3 and NF‐κB Inflammatory Pathways and Maintained Genital Functions by Ameliorating CD‐MPR, KISS‐1, AQP4 and Claudin‐1 Expressions
Authors: Topsakal Senay , Ozmen Ozlem , Ozcan Kadriye Nilay , Asci Halil , Imeci Orhan Berk , Sevuk Mehmet Abdulkadir , Kosar Pinar Aslan 
Published: February 2025

ABSTRACTFluvoxamine (FLV), a selective serotonin reuptake inhibitor, is commonly used to treat anxiety, major depressive disorder and obsessive‐compulsive disorder, among other psychiatric conditions. This study aims to evaluate the effectiveness of FLV in mitigating damage caused by lipopolysaccharide (LPS) to the female genital tract. Thirty‐two female Wistar Albino rats were randomly divided into four groups: control, LPS, LPS‐FLV and FLV. At the end of the experimental period, tissues from the ovaries, fallopian tubes and uterus were collected for histological, immunohistochemical and genetic analyses. Histological examination of the LPS group revealed mild to moderate bleeding, oedema and neutrophil infiltration. Additionally, there were signs of endometrial damage in the uterus and loss of cilia in the fallopian tubes. Immunohistochemical analysis showed that LPS increased the expressions of nuclear factor kappa beta (NF‐κB) and cation‐dependent mannose 6‐phosphate receptors (CD‐MPR) and reduced kisspeptin‐1 (KISS‐1) expression. Genetic analysis indicated that LPS increased the expression of the NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) and aquaporin4 (AQP4) genes while decreasing Claudin‐1 expression. However, all these adverse effects were reversed by FLV treatment. The study's findings suggest that FLV may be beneficial in treating LPS‐induced damage to the female reproductive system.
Effects of GLP‐1 Receptor Agonists in Alcohol Use Disorder
Authors: Klausen Mette Kruse , Knudsen Gitte Moos , Vilsbøll Tina , Fink‐Jensen Anders 
Published: February 2025

ABSTRACTIn the search for novel treatment strategies for alcohol use disorder (AUD), glucagon‐like peptide‐1 (GLP‐1) receptor agonists (GLP‐1RAs) approved for treating Type 2 diabetes and obesity have caught much attention. GLP‐1 is a naturally occurring peptide produced in the small intestines and the brain, regulating plasma glucose levels and satiety. This focused review will report on the preclinical studies, case stories, register‐based cohort studies, brain‐imaging data and secondary analysis of clinical data supporting the role of GLP‐1RAs as a novel treatment of AUD. Several clinical trials are ongoing, examining the potential effects of the GLP‐1RA semaglutide in AUD.