bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital diplomacy against international stigmatization: the Bukele case
Authors: Parthenay Kevin 
Published: January 2024

Abstract
The article addresses the diversity of digital diplomatic strategies used by governmental actors to fight international stigmatization. Faced with structural limitations, the leaders of small states use it to defend their political project's image or reputation when they come under international criticism for deviating from or transgressing international norms. Borrowing from Erving Goffman, I draw on the idea that social networks can be conceptualized as orders of interaction, in which digital diplomatic strategies can be put in place and international politicization and normative debates can develop. An examination of Salvadoran president Nayib Bukele's Twitter posts from January 2019 to May 2022, during a period of increasing international criticism regarding the authoritarian–populist drift in El Salvador, improves our knowledge of the diversity of digital diplomatic strategies. Consequently, this enlightens us on the constitutive elements of how small states manage their relationship with external actors, their image and status, and eventually how they challenge the international order, international norms and powers.
Narrative alliances: the discursive foundations of international order
Authors: Homolar Alexandra , Turner Oliver 
Published: January 2024

Abstract
Alliances are generally understood as groupings of states that combine to aggregate their physical capabilities against security threats. In this article we suggest transposing this well-established terminology of inter-state allegiance to the dimension of narrative. Focusing on the example of the ‘rules-based order’ (RBO), we provide a new conceptual entry point for understanding the complex relationship between order and discourse at the international level. Specifically, we examine how countries such as the United States, the United Kingdom, Australia, India and Japan—with varying degrees of consistency and coherence—go beyond merely proclaiming the existence of an established international system of cooperation, commitments and norms. They collectively tell a political story of the rules-based order—including its age, nature, purpose and sources of vulnerability—that rests on declaring some codes of conduct acceptable and appropriate while denouncing others as deviant. We argue that rallying behind a shared vision of international organization demarcates the boundaries of international legitimacy and establishes imperatives to act in defence of particular visions of international organization.
Open-label extension of a randomized trial investigating safety and efficacy of rhPTH(1–84) in hypoparathyroidism
Authors: Khan Aliya A , Abbott Lisa G , Ahmed Intekhab , Ayodele Olulade , Gagnon Claudia , Finkelman Richard D , Mezosi Emese , Rejnmark Lars , Takacs Istvan , Yin Shaoming , Ing Steven W 
Published: January 2024

Abstract

Hypoparathyroidism (HypoPT) is a rare disease, often inadequately controlled by conventional treatment. PARALLAX was a mandatory post-marketing trial assessing pharmacokinetics and pharmacodynamics of different dosing regimens of recombinant human parathyroid hormone 1–84 (rhPTH[1–84]) for treating HypoPT. The present study (NCT03364738) was a phase 4, 1-yr open-label extension of PARALLAX. Patients received only 2 doses of rhPTH(1–84) in PARALLAX and were considered treatment-naive at the start of the current study. rhPTH(1–84) was initiated at 50 μg once daily, with doses adjusted based on albumin-corrected serum calcium levels. Albumin-corrected serum calcium (primary outcome measure), health-related quality of life (HRQoL), adverse events, and healthcare resource utilization (HCRU) were assessed. The mean age of the 22 patients included was 50.0 yr; 81.8% were women, and 90.9% were White. By the end of treatment (EOT), 95.5% of patients had albumin-corrected serum calcium values in the protocol-defined range of 1.88 mmol/L to the upper limit of normal. Serum phosphorus was within the healthy range, and albumin-corrected serum calcium-phosphorus product was below the upper healthy limit throughout, while mean 24-h urine calcium excretion decreased from baseline to EOT. Mean supplemental doses of calcium and active vitamin D were reduced from baseline to EOT (2402–855 mg/d and 0.8–0.2 μg/d, respectively). Mean serum bone turnover markers, bone-specific alkaline phosphatase, osteocalcin, procollagen type I N-terminal propeptide, and type I collagen C-telopeptide increased 2–5 fold from baseline to EOT. The HCRU, disease-related symptoms and impact on HRQoL improved numerically between baseline and EOT. Nine patients (40.9%) experienced treatment-related adverse events; no deaths were reported. Treatment with rhPTH(1–84) once daily for 1 yr improved HRQoL, maintained eucalcemia in 95% of patients, normalized serum phosphorus, and decreased urine calcium excretion. The effects observed on urine calcium and the safety profile are consistent with previous findings.

Clinical trial identifier
NCT03364738.
How does an urban landscape influence spatiotemporal ecology of South American coatis (Nasua nasua)?
Authors: Barreto Wanessa Teixeira Gomes , de Macedo Gabriel Carvalho , Santos Filipe Martins , Rucco Andreza Castro , Sano Nayara Yoshie , de Assis William Oliveira , Herrera Heitor Miraglia , Porfírio Grasiela Edith de Oliveira , Oliveira-Santos Luiz Gustavo Rodrigues 
Published: January 2024

Abstract
Increasing urbanization and consequent habitat fragmentation and loss call for studies of the influence of urbanization on native fauna. South American Coati (Procyonidae: Nasua nasua) live in groups and are common in urban areas of South America. Here, we aimed to understand how coatis occupy and select space, and whether they change their circadian activity in an urban environment. We estimated home range sizes, verified any overlap, and evaluated the effects of sex and weight on home range size. We also described coati activity patterns associated with habitat selection. Animals established their home ranges only within the study area, with few exploratory exits to surrounding areas. Furthermore, our home range estimates of 0.66 km2 are lower than previously found in natural habitats. We did not observe an effect of sex or weight on home range size. Coatis predominantly selected forested areas and explored houses only early in the morning. We suggest that this demonstrates the need for forested areas for survival of the species. Regarding activity patterns, coatis were active only during the day, as described for the species in its natural environment. Human barriers—in addition to human refuse that serves as food—could reduce the home range sizes. Our data demonstrate differences in home range size, but not circadian activity or habitat selection when compared to coatis in their natural environment.
Beta diversity patterns in Andean rodents: current and historical factors as drivers of turnover and nestedness
Authors: Novillo Agustina , Lanzone Cecilia , Jayat J Pablo , Teta Pablo , Ojeda Agustina A , Cristobal Luciana , Ojeda Ricardo A 
Published: January 2024

Abstract
The Andes are known to be one of the most species-rich regions on Earth, with their origination promoting formation of new habitats and acting as climatic barriers. This orogenic event was structured latitudinally with 3 major segments having different formation times and with different environmental and historical conditions. The Andean region has been historically important in the evolutionary history of small mammals and is considered the region of Earth with the highest values of rodent species richness and turnover. Therefore, the region provides an excellent opportunity to evaluate mechanisms involved in structuring rodent assemblages and beta diversity patterns. Here, we assessed spatial patterns of rodent beta diversity along the Andes Mountains, with specific goals of examining patterns of turnover and nestedness as 2 recognized processes that drive species composition. We explored the role of spatial, climate, and historical factors on beta diversity patterns using geographic range maps for 432 rodent species to construct a species presence–absence matrix. We used piecewise regressions to identify latitudinal breakpoints in turnover and nestedness, and conducted multiple regressions and variation-partitioning approaches to assess the contribution of each set of postulated drivers in shaping beta diversity patterns. Beta diversity decreases from north to south. The highest turnover was located at the Northern Andes (5°N and 10°S) and western-central Andes (20°S and 35°S). Nestedness was higher below 40°S and in some areas of the western-central Andes between 15° and 20°S. Turnover and nestedness registered breakpoints coincident with the Central and Southern Andes limit. Turnover explained most of the beta diversity for all segments, although within the Southern Andes there was also some contribution of nestedness. In all segments, beta diversity was mainly explained by spatial factors with minor contributions from spatially structured climate (Northern Andes), interaction of all factors (Central Andes), and the interaction between current climate and history (Southern Andes).
Measuring the impact of COVID-19 on cancer survival using an interrupted time series analysis
Authors: Lambert Pascal , Galloway Katie , Feely Allison , Bucher Oliver , Czaykowski Piotr , Hebbard Pamela , Kim Julian O , Pitz Marshall , Singh Harminder , Thiessen Maclean , Decker Kathleen M 
Published: January 2024

Abstract

Background
Few studies have investigated the impact of the COVID-19 pandemic on cancer survival. Those studies that have included pandemic vs prepandemic comparisons can mask differences during different periods of the pandemic such as COVID-19 waves. The objective of this study was to investigate the impact of the COVID-19 pandemic on cancer survival using an interrupted time series analysis and to identify time points during the pandemic when observed survival deviated from expected survival.

Methods
A retrospective population-based cohort study that included individuals diagnosed with cancer between January 2015 and September 2021 from Manitoba, Canada, was performed. Interrupted time series analyses with Royston–Parmar models as well as Kaplan–Meier survival estimates and delta restricted mean survival times at 1 year were used to compare survival rates for those diagnosed before and after the pandemic. Analyses were performed for 11 cancer types.

Results
Survival at 1 year for most cancer types was not statistically different during the pandemic compared with prepandemic except for individuals aged 50-74 years who were diagnosed with lung cancer from April to June 2021 (delta restricted mean survival times = −31.6 days, 95% confidence interval [CI] = −58.3 to −7.2 days).

Conclusions
With the exception of individuals diagnosed with lung cancer, the COVID-19 pandemic did not impact overall 1-year survival in Manitoba. Additional research is needed to examine the impact of the pandemic on long-term cancer survival.
Cultivating a capability for empathy in the Bologna system—the shortcomings of economics and the importance of the civil
Authors: Schuck Dirk , Pecchi Lorenzo 
Published: January 2024

Abstract
A central aim of the original Bologna Declaration in 1999 was to give the opportunity of advancement in education to every European citizen. According to the Declaration, this goal is worth achieving not simply in order to provide better-qualified workers within the European Union, rather, the aim of higher education within the European Union is understood in a holistic sense as a prerequisite for the composition of a well-functioning European civil society. How can such an ambitious goal be achieved? In this article, we propose that the core capability at stake is that of empathy which, for this reason, should be central to programmes of European higher education. Empathy is not regarded as just a property of specific individuals but as an attribute which must be ascribed to specific forms of civil intercourse. Therefore, what is needed in European higher education is the provision of a social environment for students which allows for civil-cultivation, and for processes of self-cultivation. Self-cultivation, as described here, means more than a refinement of manners; rather, it refers to the development of a civil mode for approaching others: a mode that is sensitive and self-aware at the same time, and which can be regarded as arising out of a shared European heritage interconnecting rhetoric and sociability.
A phytochrome/phototropin chimeric photoreceptor promotes growth of fern gametophytes under limited light conditions
Authors: Kimura Izumi , Kanegae Takeshi 
Published: January 2024

Abstract
Many ferns thrive even in low-light niches such as under an angiosperm forest canopy. However, the shade adaptation strategy of ferns is not well understood. Phytochrome 3/neochrome (phy3/neo) is an unconventional photoreceptor, found in the fern Adiantum capillus-veneris, that controls both red and blue light-dependent phototropism and chloroplast photorelocation, which are considered to improve photosynthetic efficiency in ferns. Here we show that phy3/neo localizes not only at the plasma membrane but also in the nucleus. Since both phototropism and chloroplast photorelocation are mediated by membrane-associated phototropin photoreceptors, we speculated that nucleus-localized phy3/neo possesses a previously undescribed biological function. We reveal that phy3/neo directly interacts with Adiantum cryptochrome 3 (cry3) in the nucleus. Plant cryptochromes are blue light receptors that transcriptionally regulate photomorphogenesis; therefore, phy3/neo may function via cry3 to synchronize light-mediated development with phototropism and chloroplast photorelocation to promote fern growth under low-light conditions. Furthermore, we demonstrate that phy3/neo regulates the expression of the Cyclin-like gene AcCyc1 and promotes prothallium expansion growth. These findings provide insight into the shade adaptation strategy of ferns and suggest that phy3/neo plays a substantial role in the survival and growth of ferns during the tiny gametophytic stage under low-light conditions, such as those on the forest floor.
Molecular prognostication in grade 3 meningiomas and p16/MTAP immunohistochemistry for predicting CDKN2A/B status
Authors: Tosefsky Kira , Martin Karina Chornenka , Rebchuk Alexander D , Wang Justin Z , Nassiri Farshad , Lum Amy , Zadeh Gelareh , Makarenko Serge , Yip Stephen 
Published: January 2024

Abstract

Background
The World Health Organization 2021 classification introduces molecular grading criteria for anaplastic meningiomas, including TERT promoter (TERTp) mutations and CDKN2A/B homozygous deletion. Additional adverse prognostic factors include H3K27me3 and BAP1 loss. The aim of this study was to explore whether these molecular alterations stratified clinical outcomes in a single-center cohort of grade 3 meningiomas. Additionally, we examined whether p16 and MTAP immunohistochemistry can predict CDKN2A/B status.

Methods
Clinical and histopathological information was obtained from the electronic medical records of grade 3 meningiomas resected at a tertiary center between 2007 and 2020. Molecular testing for TERTp mutations and CDKN2A/B copy-number status, methylation profiling, and immunohistochemistry for H3K27me3, BAP1, p16, and methylthioadenosine phosphorylase (MTAP) were performed. Predictors of survival were identified by Cox regression.

Results
Eight of 15 cases demonstrated elevated mitotic index (≥20 mitoses per 10 consecutive high-power fields), 1 tumor exhibited BAP1 loss, 4 harbored TERTp mutations, and 3 demonstrated CDKN2A/B homozygous deletion. Meningiomas with TERTp mutations and/or CDKN2A/B homozygous deletion showed significantly reduced survival compared to anaplastic meningiomas with elevated mitotic index alone. Immunohistochemical loss of p16 and MTAP demonstrated high sensitivity (67% and 100%, respectively) and specificity (100% and 100%, respectively) for predicting CDKN2A/B status.

Conclusions
Molecular alterations of grade 3 meningiomas stratify clinical outcomes more so than histologic features alone. Immunohistochemical loss of p16 and MTAP show promise in predicting CDKN2A/B status.
Disparities in Coronavirus Disease 2019 Clinical Outcomes and Vaccination Coverage Among Migrants With Human Immunodeficiency Virus in the PISCIS Cohort: A Population-Based Propensity Score–Matched Analysis
Authors: Nomah Daniel K , Díaz Yesika , Bruguera Andreu , Moreno-Fornés Sergio , Aceiton Jordi , Reyes-Urueña Juliana , Llibre Josep M , Falcó Vicenç , Imaz Arkaitz , Fanjul Francisco Javier , Peraire Joaquim , Deig Elisabet , Domingo Pere , Inciarte Alexy , Casabona Jordi , Miró José M 
Published: January 2024

Abstract

Background
Coronavirus disease 2019 (COVID-19) disproportionately affects migrants and ethnic minorities, including those with human immunodeficiency virus (HIV). Comprehensive studies are needed to understand the impact and risk factors.

Methods
Using data from the PISCIS cohort of people with HIV (PWH) in Catalonia, Spain, we investigated COVID-19 outcomes and vaccination coverage. Among 10 640 PWH we compared migrants and non-migrants assessing rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing, diagnosis, and associated clinical outcomes through propensity score matching and multivariable Cox regression.

Results
The cohort (mean age, 43 years; 83.5% male) included 57.4% (3053) Latin American migrants. Migrants with HIV (MWH) had fewer SARS-CoV-2 tests (67.8% vs 72.1%, P &lt; .0001) but similar COVID-19 diagnoses (29.2% vs 29.4%, P = .847) compared to Spanish natives. Migrants had lower complete vaccination (78.9% vs 85.1%, P &lt; .0001) and booster doses (63.0% vs 65.5%, P = .027). COVID-19 hospitalizations (8.1% vs 5.1%, P &lt; .0001) and intensive care unit (ICU) admissions (2.9% vs 1.2%, P &lt; .0001) were higher among migrants, with similar hospitalization duration (5.5 vs 4.0 days, P = .098) and mortality (3 [0.2%] vs 6 [0.4%], P = .510). Age ≥40 years, CD4 counts &lt;200 cells/μL, ≥2 comorbidities, and incomplete/nonreception of the SARS-CoV-2 vaccine increased the risk of severe COVID-19 among migrants.

Conclusions
MWH had lower rates of SARS-CoV-2 testing and vaccination coverage, although the rates of COVID-19 diagnosis were similar between migrants and non-migrants. Rates of COVID-19–associated hospitalizations and ICU admissions were higher among migrants in comparison with non-migrants, with similar hospitalization duration and mortality. These findings can inform policies to address disparities in future pandemic responses for MWH.
Credit Freezes, Equilibrium Multiplicity, and Optimal Bailouts in Financial Networks
Authors: Jackson Matthew O , Pernoud Agathe 
Published: January 2024

Abstract
We analyze how interdependencies in financial networks can lead to self-fulfilling insolvencies and multiple possible equilibrium outcomes. Multiplicity arises if a certain type of dependency cycle exists in the network. We show that finding the cheapest bailout policy that prevents self-fulfilling insolvencies is computationally hard, but that the optimal policy has intuitive features in some typical network structures. Leveraging indirect benefits ensures systemic solvency at a cost that never exceeds half of the overall shortfall. In core-periphery networks, it is optimal to bail out peripheral banks first as opposed to core banks.
Asian Americans’ Racialized Incorporation into the Political Field
Authors: Liang Chen 
Published: January 2024

Abstract
I use Asian Americans’ political participation to examine how the racialization of Asian Americans manifests in the political field, and how such processes shape Asian Americans’ racialized experiences and identity. Based on interviews with 95 Asian American political candidates and organizers in Houston, Texas, the findings show that, regardless of respondents’ motivation for participating in politics, most of them have encountered racial discrimination based on the “perpetual foreigner” racial trope in the political field and have observed how race dictates the way politics operates in the United States. The racialized experiences in politics lead to these organizers’ awareness of their Asian American racial status and their belief that political participation is a means to assert their political belonging to U.S. society and to transform their marginalized racial status. This facilitates their sense of linked fate with other individuals with Asian heritages in the United States and sustains their political activism. The findings suggest that Asian Americans are going through a process of racialized incorporation in the political field, as they are “sorted” along racial lines when becoming part of the U.S. hierarchical political system.
A corn-fermented protein ingredient can be included in early nursey diets without compromising pig growth performance and health status
Authors: Garavito-Duarte Yesid R , Levesque Crystal L , Herrick Kevin , Perez-Palencia Jorge Y 
Published: January 2024

Abstract
In nursery diets, ingredients with high protein content and highly digestible nutrients, such as corn-fermented protein product with added yeast mass (GDDY), can be included as an alternative to common protein sources. This study investigated the dietary inclusion of GDDY as an alternative protein source on growth performance and intestinal health of weaned pigs. A total of 594 weaned pigs (5.7 ± 0.9 kg; 18.5 days of age) were allotted to 36 pens in a randomized incomplete block design. Pens were assigned to one of 4 dietary treatments: CON: a common nursery feeding program; SBM75: CON diet replacing 75% of soybean meal (SBM) with GDDY; FM/ESBM: CON diet without fish meal (FM) and enzyme-treated SBM (ESBM) + GDDY; GDDY50: CON diet replacing 50% of SBM, FM, and ESBM with GDDY. Experimental diets were formulated to meet nutrient requirements of nursery pigs and provided in meal form through four phases during the nursery period. Pig growth performance was assessed on days 7, 14, 21, 28, 42, and 53. Pen fecal score was assessed daily from days 0 to 14, and 3 times per week from days 15 to 35. Intestinal health was assessed based on plasma immunoglobulin A (IgA) concentration and the differential sugar absorption test. The total tract digestibility of dry matter (DM), crude protein (CP), gross energy (GE), and phosphorus was also evaluated. From days 0 to 7 and days 7 to 14, dietary treatment had no effect (P &gt; 0.05) on BW, ADG, and ADFI. For the rest of the experimental period, ADG and ADFI were greater (P &lt; 0.05) in pigs fed CON in comparison with those fed SBM75 and GDDY50 and did not differ from pigs fed FM/ESBM. Pigs fed GDDY50 tended (P = 0.082) to have greater serum IgA concentration on day 20 when compared with SBM75 and FM/ESBM pigs. There were no differences among dietary treatments for DM, CP, and GE digestibility. Phosphorus digestibility was higher in FM/ESBM (P &lt; 0.05) compared with SBM75 and GDDY50. These results supported the hypothesis that GDDY can be incorporated in nursery pig diets during the first couple weeks after weaning without affecting growth performance. However, in the late nursery period, inclusion levels starting at 14% can compromise performance.