bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized prognostic prediction tool for high-grade neuroendocrine cervical cancer: a SEER database analysis and single-center validation
Authors: Chen Xiaoyue , Shi Wenpei , Wang Chao , Zhu Haiyan 
Published: October 2023

Abstract
Purpose
Cervical high-grade neuroendocrine carcinoma (CHGNEC) is a rare but highly aggressive cancer. The purpose of this study is to develop a prognostic nomogram that can accurately predict the outcomes for CHGNEC patients.

Methods
We analyzed clinical data from the Surveillance, Epidemiology, and End Results (SEER) database of CHGNEC patients, including small-cell neuroendocrine carcinoma (SCNEC) and large-cell neuroendocrine carcinoma (LCNEC). We investigated patient characteristics and prognosis, and developed a prognostic nomogram model for cancer-specific survival in CHGNEC patients. External validation was conducted using real clinical cases from our hospital.

Results
Our study included 306 patients from SEER database, with a mean age of 49.9 ± 15.5 years. Most of the patients had SCNEC (86.9%). Among them, 170 died from the disease, while 136 either survived or died from other causes. Our final predictive model identified age at diagnosis, stage 1 status, stage 4 status, T1, N0, and surgery of the primary site as independent prognostic factors for CHGNEC. We validated our model using a group of 16 CHGNEC patients who underwent surgery at our center. The external validation showed that the prognostic nomogram had excellent discriminative ability, with an area under the receiver operating characteristic curve (AUC) of 0.76 (95% CI 0.49–1.00) for the prediction of 3-year cancer-specific survival (CSS) and an AUC of 0.85 (95% CI 0.62–1.00) for the prediction of 5-years CSS. The random survival forest model achieved an AUC of 0.80 (95% CI 0.56–1.00) for 3-years CSS and 0.91 (95% CI 0.72–1.00) for 5-years CSS, indicating its adequacy in predicting outcomes for CHGNEC patients.

Conclusion
Our study provides an excellent nomogram for predicting the prognosis of CHGNEC patients. The prognostic nomogram can be a useful tool for clinicians in identifying high-risk patients and making personalized treatment decisions.
Ethische Aspekte fertilitätserhaltender Maßnahmen bei jungen krebskranken Personen
Authors: Pietschmann Ines , Wiesemann Claudia 
Published: October 2023

ZusammenfassungEigene Kinder zu bekommen und eine Familie zu gründen ist für viele Menschen ein wichtiger Aspekt eines guten Lebens. Die Einschränkung der Fertilität durch Krebstherapien kann für Patient*innen eine lebensgeschichtlich bedeutsame Belastung darstellen. Deshalb muss über die Möglichkeiten von fertilitätserhaltenden Maßnahmen (FEM) aufgeklärt werden. Die Entscheidung, ob diese durchgeführt werden sollen, findet in einer ohnehin belastenden Situation statt. Die Entscheidung über FEM wirft eine Reihe ethischer Fragen auf, derer sich Ärzt*innen bei der Aufklärung und Beratung bewusst sein müssen. In der Aufklärungs- und Entscheidungssituation werden Themen der Patient*innenautonomie, des Nicht-Schadens und der Gerechtigkeit verhandelt. Auch können Einstellungen zu Partnerschaft, Fragen des Kindeswohls und Alternativen zu FEM für die Entscheidung von Betroffenen wichtig sein. Der Artikel gibt einen Überblick über relevante ethische Fragen rund um fertilitätserhaltende Maßnahmen und wie damit umgegangen werden sollte.
Male Sexual Victimization by Women: Incidence Rates, Mental Health, and Conformity to Gender Norms in a Sample of British Men
Authors: Madjlessi Jasmine , Loughnan Steve 
Published: October 2023

AbstractMale sexual victimization by women is often neglected within psychological research (Fisher & Pina, 2013). Not only is the topic understudied, incidence rates and associated psychological impacts are inconsistent across the literature (Depraetere et al., 2020; Peterson et al., 2011). The present study provides an additional estimate of male sexual victimization by women, explores its association with victim mental disorders, and examines the potential moderating role of conformity to gender norms. A sample of 1124 heterosexual British men completed an online survey consisting of a modified CDC National Intimate Partner and Sexual Violence Survey, and measures of anxiety, depression, post-traumatic stress disorder, and conformity to masculine norms. In the present sample, 71% of men experienced some form of sexual victimization by a woman at least once during their lifetime. Sexual victimization was significantly associated with anxiety, depression, and post-traumatic stress disorder. However, conformity to masculine gender norms was not a significant moderator between victimization and mental disorders. These findings further illuminate the occurrence of male sexual victimization by women, as well as the importance of continued research on the topic.
From study plans to capacity building: a journey towards health equity in cancer survivorship
Authors: Adsul Prajakta , Austin Jessica D. , Chebli Perla , Dias Emanuelle M. , Hirschey Rachel , Ravi Priyanka , Seaman Aaron T. , Vogel Rosi 
Published: October 2023

AbstractThis article highlights the importance of pausing and reflecting on one's motivation, capacity, and positionality when engaging in health equity research and encourages researchers to engage in critical self-reflection and contribute to the ongoing dialogue on the ethical conduct of health equity-focused cancer research. In response to the urgent need to address health disparities and improve health equity in cancer survivorship care, the Cancer Prevention and Control Research Network (CPCRN) Survivorship workgroup discussed developing a study focused on understanding how racism impacts patient engagement in cancer survivorship care. However, during the study's development, the workgroup recognized limitations in research team composition and infrastructure. The workgroup engaged in critical self-reflections, individually and collectively, leading to the halting of the research study. Consequently, they redirected their efforts towards strengthening the necessary infrastructure for conducting such research, including diverse investigator representation and equitable partnerships with cancer survivors. The description of this process, along with suggestions for reflection, may be helpful and informative to other researchers and research networks seeking to center marginalized voices and work in partnership to address healthcare and health equity.
Postmemory of Stalinist Repressions and the Siege of Leningrad in Olga Lavrentieva’s Graphic Novel Survilo (2019)
Authors: Kamińska-Maciąg Sylwia 
Published: October 2023

Abstract
Olga Lavrentieva’s graphic novel Survilo, published in Russia in 2019, and since then translated into a few languages, is one of the recent examples of harnessing the comic form to overcome historical taboo in contemporary children’s and young adult literature. The polemic around accounts of the Stalinist repressions in the 1930s and the period of the Leningrad siege that arose a few years ago in Russia’s cultural space shows that the quest for the truth about the past continues to haunt successive generations of Russian authors. Lavrentieva spins a narrative based on the history of her own family and, specifically, on the life of her grandmother, Valentina Survilo, whose childhood overlapped with the Great Terror with its atrocities and her adolescence with the blockade of Leningrad. The author of this article argues that although she writes about Stalinist atrocities, in her fragmented biographical graphic novel, Lavrentieva does not deconstruct the Soviet myth of the Great Patriotic War but weaves a narrative based on a particular version of postmemory. The author uses the framework of memory studies and focuses predominately on the textual layer of Survilo; however, the black-and-white vignettes composed by Lavrentieva add up to a formally and thematically thought-provoking book.
Facing the Traumatic Field in the Clinical and Social Work with Forced Migrants Through a Psychodynamic Perspective: from “Refugee Trauma” to the Clinic of Social Links
Authors: Margherita Giorgia , Tessitore Francesca 
Published: October 2023

AbstractThis article aims to rethink the clinical and social work with forced migrants through the concept of “field” as it is described in the context of Bionian psychoanalysis. The proposed approach goes beyond the individual trauma of the refugee, to arrive at a clinic of the “traumatic field” that includes, but also overcomes, the dyadic relationship searching for the link between intra-psychic, inter-psychic and social dimensions. The work with mediation “devices”, the dream field, and the group as a social witness will be discussed as operational tools of a clinical social practice of intervention extended to relevant emerging social contexts.
Controllable Deformations of Unconstrained Ideal Nematic Elastomers
Authors: Mihai L. Angela , Goriely Alain 
Published: October 2023

AbstractWe establish that, for ideal unconstrained uniaxial nematic elastomers described by a homogeneous isotropic strain-energy density function, the only smooth deformations that can be controlled by the application of surface tractions only and are universal in the sense that they are independent of the strain-energy density are those for which the deformation gradient is constant and the liquid crystal director is either aligned uniformly or oriented randomly in Cartesian coordinates. This result generalizes the classical Ericksen’s theorem for nonlinear homogeneous isotropic hyperelastic materials. While Ericksen’s theorem is directly applicable to liquid crystal elastomers in an isotropic phase where the director is oriented randomly, in a nematic phase, the constitutive strain-energy density must account also for the liquid crystal orientation which leads to significant differences in the analysis compared to the purely elastic counterpart.
Paramagnetic NMR to study iron sulfur proteins: 13C detected experiments illuminate the vicinity of the metal center
Authors: Querci Leonardo , Grifagni Deborah , Trindade Inês B. , Silva José Malanho , Louro Ricardo O. , Cantini Francesca , Piccioli Mario 
Published: October 2023

AbstractThe robustness of NMR coherence transfer in proximity of a paramagnetic center depends on the relaxation properties of the nuclei involved. In the case of Iron-Sulfur Proteins, different pulse schemes or different parameter sets often provide complementary results. Tailored versions of HCACO and CACO experiments significantly increase the number of observed Cα/C’ connectivities in highly paramagnetic systems, by recovering many resonances that were lost due to paramagnetic relaxation. Optimized 13C direct detected experiments can significantly extend the available assignments, improving the overall knowledge of these systems. The different relaxation properties of Cα and C’ nuclei are exploited in CACO vs COCA experiments and the complementarity of the two experiments is used to obtain structural information. The two [Fe2S2]+ clusters containing NEET protein CISD3 and the one [Fe4S4]2+ cluster containing HiPIP protein PioC have been taken as model systems. We show that tailored experiments contribute to decrease the blind sphere around the cluster, to extend resonance assignment of cluster bound cysteine residues and to retrieve details on the topology of the iron-bound ligand residues.
How do roles impact suicidal agents’ obligations?
Authors: Dowie Suzanne E. 
Published: October 2023

AbstractIn this paper, I assess the role responsibility argument that claims suicidal agents have obligations to specific people not to kill themselves due to their roles. Since the plausibility of the role responsibility argument is clearest in the parent–child relationship, I assess parental obligations. I defend a view that says that normative roles, such as those of a parent, are contractual and voluntary. I then suggest that the normative parameters for some roles preclude permissible suicide because the role-related contract includes a promise to provide continuing care and emotional support. I propose that as we have established criteria for morally acceptable reasons for cancelling, voiding, or amending a contract, we can apply these to the role responsibility argument to establish grounds for releasing a parent from his role-related and contractual obligations. Failure to fulfil one’s contractual roles may not be blameworthy, depending upon the circumstances. I propose the factors determining culpability in failure to fulfil one’s role-related obligations are: intention, voluntariness, diminished responsibility, mental capacity, and foreseeability.
Neighbourhood search for energy minimisation in flexible job shops under fuzziness
Authors: García Gómez Pablo , Vela Camino R. , González-Rodríguez Inés 
Published: October 2023

AbstractUncertainty pervades real life and supposes a challenge for all industrial processes as it makes it difficult to predict the outcome of otherwise risk-free activities. In particular, time deviation from projected objectives is one of the main sources of economic losses in manufacturing, not only for the delay in production but also for the energy consumed by the equipment during the additional unexpected time they have to work to complete their labour. In this work we deal with uncertainty in the flexible job shop, one of the foremost scheduling problems due to its practical applications. We show the importance of a good model to avoid introducing unwanted imprecision and producing artificially pessimistic solutions. In our model, the total energy is decomposed into the energy required by resources when they are actively processing an operation and the energy consumed by these resources simply for being switched on. We propose a set of metrics and carry out an extensive experimental analysis that compares our proposal with the more straightforward alternative that directly translates the deterministic model. We also define a local search neighbourhood and prove that it can reach an optimal solution starting from any other solution. Results show the superiority of the new model and the good performance of the new neighbourhood.
Why Deliberation and Voting Belong Together
Authors: Chambers Simone , Warren Mark E. 
Published: October 2023

AbstractThe field of deliberative democracy now generally recognizes the co-dependence of deliberation and voting. The field tends to emphasize what deliberation accomplishes for vote-based decisions. In this paper, we reverse this now common view to ask: In what ways does voting benefit deliberation? We discuss seven ways voting can complement and sometimes enhance deliberation. First, voting furnishes deliberation with a feasible and fair closure mechanism. Second, the power to vote implies equal recognition and status, both morally and strategically, which is a condition of democratic deliberation. Third, voting politicizes deliberation by injecting the strategic features of politics into deliberation—effectively internalizing conflict into deliberative processes, without which they can become detached from their political environments. Fourth, anticipation of voting may induce authenticity by revealing preferences, as what one says will count. Fifth, voting preserves expressions of dissent, helping to push back against socially induced pressures for consensus. Sixth, voting defines the issues, such that deliberation is focused, and thus more likely to be effective. And, seventh, within contexts where votes are public—as in representative contexts, voting can induce accountability, particularly for one’s claims. We then use these points to discuss four general types of institutions—general elections, legislatures, minipublics, and minipublics embedded in referendum processes—that combine talking and voting, with the aim of identifying designs that do a better or worse job of capitalizing upon the strengths of each.
Thrombozytenstörungen bei Urämie
Authors: Baaten Constance C. F. M. J. , Vondenhoff Sonja , Jankowski Joachim , Noels Heidi 
Published: October 2023

ZusammenfassungChronisch niereninsuffiziente Patienten (CKD[„chronic kidney disease“]-Patienten) haben ein erhöhtes Risiko für kardiovaskuläre Erkrankungen („cardiovascular disease“; CVD) und Thrombose, wobei etwa die Hälfte der Patienten mit fortgeschrittener CKD an CVD verstirbt. Thrombozyten spielen eine wichtige physiologische Rolle bei der Aufrechterhaltung der Hämostase, tragen aber auch zu CVD bei: Sie sind Hauptakteure bei der Bildung von Thromben und der einhergehenden Entzündungsreaktion, tragen zur Atherosklerose als Hauptursache für z. B. Herzinfarkte bei und können auch kardiale Umbauprozesse beeinflussen. CKD-Patienten leiden gleichzeitig unter einem erhöhten Thrombose- und Blutungsrisiko, was die antithrombotische Therapie von CKD-Patienten erschwert. CKD-Patienten, insbesondere bei fortgeschrittener CKD, sind bislang in klinischen Studien zur antithrombotischen Therapie stark unterrepräsentiert, sodass die derzeitige klinische Praxis hauptsächlich auf Post-hoc-Subgruppenanalysen klinischer Studien und Beobachtungsstudien beruht. Bislang sind keine Leitlinien verfügbar, die für diese Patientengruppe optimiert wurden. Sowohl der Phänotyp als auch die Funktionen der Thrombozyten von CKD-Patienten sind verändert. Ein besseres Verständnis der zugrunde liegenden Mechanismen würde eine weitere Verbesserung der antithrombotischen Therapie bei CKD unterstützen. Im Folgenden werden die Rolle der Thrombozyten bei CVD, die Auswirkungen von CKD auf die Thrombozyten und deren zugrunde liegende Mechanismen sowie die aktuellen Erkenntnisse und Grenzen der antithrombotischen Therapie bei CKD-Patienten erörtert.
Framing Texts and Images: Critical and Posthumous Editions in the Digital Single Market
Authors: Sappa Cristiana , Widła Bohdan 
Published: October 2023

AbstractAlthough Art. 14 of the Directive on Copyright in the Digital Single Market (CDSM Directive) was introduced mostly to deal with issues connected with non-original photographs of public domain works, it also impacts the protection of posthumous and critical editions. Whenever a work of visual art that belongs in the public domain becomes the object of an edition, Art. 14 CDSM Directive excludes its protection under neighbouring rights. In the case of complex works, embedding original contributions belonging to different genres, Art. 14 CDSM Directive applies only if visual elements are predominant in the given work and as long as it is not possible to exploit the work of visual art without using other contributions embedded in the complex work. At the same time, Art. 14 CDSM Directive indirectly confirms that an edition may be protected by copyright if it is original. The particularly low threshold of originality required makes the presence of copyright quite common in three-dimensional and two-dimensional reproductions of works in the public domain that can qualify as editions. Then, with reference to textual works, the limits of originality are challenged: although there is little doubt that the person preparing a critical edition faces choices, they may not necessarily be free and creative. Editorial interference with the text can be compared to findings made by historians during their research and, as such, remain unprotected by copyright. Such an edition may still be protected within the regime of the neighbouring right in those few member states that decided to implement it. Eventually, as is the case nowadays with many aspects of human activity, the future of IP protection of various editions will become murkier due to the advent of new artificial intelligence technologies. For example, models are already being developed to automate the arduous and difficult process of transcription of manuscripts, as well as to ensure appropriate restoration of works of visual art. In particular, the further rapid development of artificial intelligence may cause the neighbouring rights in editions to become at least partially obsolete if the process of preparation of editions becomes devoid of human input. And this would have an impact on the copyright presence as well.
Application of Hybrid Laser Arc Welding for Construction of LNG Tanks Made of Thick Cryogenic 9% Ni Steel Plates
Authors: Gook Sergej , El-Batahgy Abdel-Monem , Gumenyuk Andrey , Biegler Max , Rethmeier Michael 
Published: October 2023

AbstractHybrid laser-arc welding (HLAW) was applied for butt welding of 14.5 mm thick plates of ferritic cryogenic steel X8Ni9 containing 9% Ni, which is used for manufacturing storage and transport facilities of liquefied natural gas (LNG). The weld seam formation and the achievable metallurgical and mechanical properties of the hybrid welds were investigated experimentally for two types of filler wire, an austenitic wire dissimilar to the base metal (BM) and an experimentally produced matching ferritic wire. Safe penetration and uniform distribution of the austenitic filler metal in the narrow hybrid weld could only be achieved in the upper, arc-dominated part of the weld. The pronounced heterogeneous distribution of the austenitic filler metal in the middle part and in the root area of the weld could not ensure sufficient notched impact toughness of the weld metal (WM). As a result, a decrease in the impact energy down to 17 ± 3 J was observed, which is below the acceptance level of ≥ 34 J for cryogenic applications. In contrast, the use of a matching ferritic filler wire resulted in satisfactory impact energy of the hybrid welds of up to 134 ± 52 J at the concerned cryogenic temperature of -196 °C. The obtained results contribute to an important and remarkable conversion in automated manufacturing of LNG facilities. In other words, the results will help to develop a new laser-based welding technology, where both quality and productivity are considered.The efficiency of the developed welding process has been demonstrated by manufacturing a prototype where a segment of the inner wall of large size LNG storage tank was constructed. In this concern, hybrid laser arc welding was conducted in both horizontal (2G) and vertical (3G) positions as a simulation to the actual onsite manufacturing. The prototype was fabricated twice where its quality was confirmed based on non-destructive and destructive examinations.
p-Type Two-Dimensional Semiconductors: From Materials Preparation to Electronic Applications
Authors: Tang Lei , Zou Jingyun 
Published: October 2023

Abstract
Two-dimensional (2D) materials are regarded as promising candidates in many applications, including electronics and optoelectronics, because of their superior properties, including atomic-level thickness, tunable bandgaps, large specific surface area, and high carrier mobility. In order to bring 2D materials from the laboratory to industrialized applications, materials preparation is the first prerequisite. Compared to the n-type analogs, the family of p-type 2D semiconductors is relatively small, which limits the broad integration of 2D semiconductors in practical applications such as complementary logic circuits. So far, many efforts have been made in the preparation of p-type 2D semiconductors. In this review, we overview recent progresses achieved in the preparation of p-type 2D semiconductors and highlight some promising methods to realize their controllable preparation by following both the top–down and bottom–up strategies. Then, we summarize some significant application of p-type 2D semiconductors in electronic and optoelectronic devices and their superiorities. In end, we conclude the challenges existed in this field and propose the potential opportunities in aspects from the discovery of novel p-type 2D semiconductors, their controlled mass preparation, compatible engineering with silicon production line, high-κ dielectric materials, to integration and applications of p-type 2D semiconductors and their heterostructures in electronic and optoelectronic devices. Overall, we believe that this review will guide the design of preparation systems to fulfill the controllable growth of p-type 2D semiconductors with high quality and thus lay the foundations for their potential application in electronics and optoelectronics.