bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptom-level effects of SSRIs in depression studies in a large-scale study programme: efficacy, effects of baseline severity, impact on suicidality, and more
Authors: Näslund J. 
Published: January 2024

Abstract
Conclusions about the efficacy of antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs), in clinical trials have generally been based on analyses of total sum scores on psychometric rating scales, mainly the Hamilton Depression Rating Scale (HDRS). However, this rating scale has several drawbacks, such as multidimensionality and a tendency of several items to pick up side-effects. Therefore, analyses that only rely on global drug treatment effects on the HDRS and similar scales risk misrepresenting important properties of any drugs investigated.
This presentation concerns the findings of a research project investigating item-level effects of SSRIs in treating depression in a material encompassing 8262 patients having participated in pre- and post-marketing industry-sponsored studies concering paroxetine, sertraline or citalopram. This has been a fruitful endeavour, having resulted in numerous research papers. Though our main focus at the outset was to investigate if a comparatively low efficacy of SSRIs in clinical trials was an artefact related to the use of HDRS sum scores as the main outcome (which was indeed the case), we have also used this material to investigate a number of other important questions relating to the influence of SSRIs on the various symptoms experienced by patients with depression. Major findings discussed in the presentation include: i) confirmation of early (but not widely known) reports that SSRIs significantly reduce core depression symptoms already after a week of treatment ii) strong evidence for SSRIs being equally effective in treating core depressive symptoms in mild as well as severe depression, earlier reported differences apparently being explained by differences in terms of effects (and prevalence) of non-core symptoms iii) SSRIs do not seem to exacerbate suicidality as measured by the relevant item of the HDRS scale - indeed, both average scores as well as likelihood of worsening are significantly reduced already at week 1. The implications of these, and other, findings are discussed in relation to both the role of SSRIs in the clinic as well as pre-clinical research into e.g. the mode of action of these drugs.

Disclosure of Interest
None Declared
Cerebral networks of apathy and goal-oriented patterns of actimetry in late-life depression
Authors: Robert G. 
Published: January 2024

Abstract
Apathy and goal-oriented behaviors are key dimensions of late-life depression (LLD) and are iteratively associated with cognitive decline in most neuropsychiatric disorders. However, scales and criteria remains insufficient to provide robust individual biomarkers that could foster personalized therapeutic approaches. Therefore, dimensional and digital phenotyping offer new possibilities of stratifying LLD population. This presentation will show our recent results of functional connectivity cerebral networks associated with multidimensional paper-and-pen measures of apathy, including the default mode and the cingulo-opercular networks. We will also show how dimensional reduction (functional principal component analysis) of 3 days actimetry measures are associated with both FC and inflammatory measures (diffusion and multicompartment indices such as free water and neurite orientation dispersion), providing arguments for different pathophysiological mechanisms underlying goal-oriented behaviors and reinforcing actimetry as a good candidate for individual biomarker of cognitive decline in LLD. Finally, machine learning approaches using combination of different, yet correlated, indices of actimetry will be presented and discussed with their corresponding classifying accuracies (outside of cerebral imaging). Altogether, this presentation aims at bridging the gap between cerebral imaging and digital phenotyping to enhance personalized medicine in the field of old-age psychiatry and cognitive decline prevention.

Disclosure of Interest
None Declared
Sex-Related Differences in Self-Reported Symptoms at Diagnosis in Pheochromocytomas and Paragangliomas
Authors: Parisien-La Salle Stefanie , Bourdeau Isabelle 
Published: January 2024

Abstract

Context
Biological sex can play a role in the severity of certain diseases.

Objective
Our objective was to evaluate whether sex-related differences affect the signs and symptoms of pheochromocytomas and paragangliomas (PPGLs) at presentation.

Methods
We reviewed the records of patients with PPGLs at our center from 1995 to 2022.

Results
Our study included 385 patients with PPGLs: 118 (30.6%) head and neck paragangliomas (HNPGLs), 58 (15.1%) thoracoabdominal paragangliomas (TAPGLs) and 209 (54.3%) pheochromocytomas (PHEOs). The cohort consisted of 234 (60.8%) women and 151 (39.2%) men. At diagnosis, more women than men presented with headaches (47.5% vs 32.4%; P = .007); however, more men presented with diabetes (21.1% vs 12.5%; P = .039). When subdivided by tumor location, headaches occurred more often in women with HNPGLs and TAPGLs (31.0% vs 11.4%; P = .0499 and 60.0% vs 21.7%; P = .0167). More men presented with diabetes among patients with PHEOs (28.2% vs 11.2%; P = .0038). In regard to nonsecretory PPGLs, women presented with a higher prevalence of headaches (46.9% vs 3.6%; P = .0002), diaphoresis (16.3% vs 0.0%; P = .0454), and palpitations (22.4% vs 0.0%; P = .0057). In patients with secretory tumors, women presented with more headaches (58.9% vs 42.7%; P = .0282) and men with more diabetes (29.3% vs 12.5%; P = .0035).

Conclusion
In our cohort, more women presented with headaches across all tumor types and secretory statuses. More men presented with diabetes among patients with PHEOs and secretory tumors. In nonsecretory PPGLs, women had more adrenergic symptoms. These findings can be explained by differences in adrenergic receptor sensitivity, self-reported symptoms, and possibly other vasoactive peptides and sex-hormone status.
COGNITIVE MECHANISMS OF FORMATION OF TEMPORAL MEANINGS IN THE ADVERTISING TOURIST NARRATIVE
Authors: Men’shikova Ekaterina E. 
Published: January 2024

Background. The article considers cognitive mechanisms of the formation of the temporal meanings in the advertising tourist narrative. Relevance of the study is determined by its correlation with modern linguistic research aimed at studying linguistic semantics in its relationship with cognitive structures. Having a multicomponent structure, time is currently positioned as an attribute of human activity and also as a phenomenon of human existence. However, there is insufficient study of the interpretive potential of time, which makes research topic relevant.
Purpose. The research purpose is as follows: to determine the cognitive mechanisms of the temporal organization of the advertising tourist narrative.
Materials and methods. Language units of various levels were used for the study, obtained from authentic online texts of advertising tourist narrative. The main research methods include analysis and synthesis of theoretical material, the continuous sampling method, descriptive method, contextual analysis method as well as cognitive modeling method.
Results. The results have shown that the main cognitive mechanisms of formation and interpretation of temporal meanings in the advertising tourist narrative include focusing, profiling, perspectivization, conceptual metaphor. Cognitive models of structuring temporal meanings, the source of which are the cognitive mechanisms outlined above, are considered.
Practical implications. The research results can be used in the development of courses on general linguistics, lexicology and cognitive linguistics.
Taking into account the specific features of teaching foreign languages in the practice of secondary schools
Authors: Bashlueva Natalya 
Published: January 2024

The main purpose of the study is to consider the specific features of teaching foreign languages in the practice of secondary schools. We are talking about three main components of language communication. When mastering many sign-forming means of a foreign language (not only written, but also sound), their description may be useful; as a result of mastering a group of structures, it is sometimes advisable to give a descriptive summary of what has been mastered. The unavoidable problems may include: a relatively small number of weekly hours and the total time allocated to learning a foreign language in the school curriculum; the workload of students in many other academic disciplines; a relatively large number of students in the classroom. An obvious and unavoidable difficulty is also the lack of an oral language environment for students. Although when using the digital environment and the capabilities of the Internet, the latter circumstance is quite easily eliminated. Successful overcoming of all these difficulties and obstacles (and the available experience suggests that they can be overcome) requires the fulfillment of two conditions:
1) the general training task should be very limited and possibly more specific;
2) only the most effective (in school conditions) teaching methods and techniques should be used.
Generalization Bounds in the Predict-Then-Optimize Framework
Authors: El Balghiti Othman , Elmachtoub Adam N. , Grigas Paul , Tewari Ambuj 
Published: January 2024

The predict-then-optimize framework is fundamental in many practical settings: predict the unknown parameters of an optimization problem and then solve the problem using the predicted values of the parameters. A natural loss function in this environment is to consider the cost of the decisions induced by the predicted parameters in contrast to the prediction error of the parameters. This loss function is referred to as the smart predict-then-optimize (SPO) loss. In this work, we seek to provide bounds on how well the performance of a prediction model fit on training data generalizes out of sample in the context of the SPO loss. Because the SPO loss is nonconvex and non-Lipschitz, standard results for deriving generalization bounds do not apply. We first derive bounds based on the Natarajan dimension that, in the case of a polyhedral feasible region, scale at most logarithmically in the number of extreme points but, in the case of a general convex feasible region, have linear dependence on the decision dimension. By exploiting the structure of the SPO loss function and a key property of the feasible region, which we denote as the strength property, we can dramatically improve the dependence on the decision and feature dimensions. Our approach and analysis rely on placing a margin around problematic predictions that do not yield unique optimal solutions and then providing generalization bounds in the context of a modified margin SPO loss function that is Lipschitz continuous. Finally, we characterize the strength property and show that the modified SPO loss can be computed efficiently for both strongly convex bodies and polytopes with an explicit extreme point representation. Funding: O. El Balghiti thanks Rayens Capital for their support. A. N. Elmachtoub acknowledges the support of the National Science Foundation (NSF) [Grant CMMI-1763000]. P. Grigas acknowledges the support of NSF [Grants CCF-1755705 and CMMI-1762744]. A. Tewari acknowledges the support of the NSF [CAREER grant IIS-1452099] and a Sloan Research Fellowship.
Limites, divisas, fronteiras
Authors: Mazzoni Júlia 
Published: January 2024

Limites, divisas, fronteiras consiste em uma série em desenvolvimento que compreende o corpo como principal meio de contato com o mundo, pertencendo a um território limiar: entre interior e exterior, entre as linhas do desenho e do bordado, entre o que o corpo absorve do espaço e como pode atuar nele.
Influenza vaccination – still a priority
Authors: Duncan Deborah 
Published: January 2024

This article was sponsored by CSL Seqirus. CSL Seqirus had no involvement in the writing or editorial process of this article. The seasonal flu campaign remains a critically important public health intervention to reduce morbidity, mortality and hospitalisation associated with flu within the struggling NHS. This is still a period of uncertainty post pandemic where last Winter we saw a surge in respiratory illness and an increase death rate associated to influenzae and pneumonia. It considers vaccine hesitancy relating it to the different at-risk groups and the role of the nurse in education. It is therefore important to identify who is eligible for vaccination and to be aware of the different vaccinations for each group. This article reviews the recommendations for the 2023–2034 seasonal influenzae period.
Starting a new school with asthma – what to advise
Authors: Henry heather 
Published: January 2024

Nurses working in general practice settings may encounter children with asthma who are about to enter school. They can provide advice to prevent exacerbations of the condition Starting a new school can be an exciting time for children and families. But if a child has asthma, it can become a concern for many reasons. Using a case study approach, this article covers how a general practice nurse may support a child with asthma during transition to a new school, or indeed during other times of educational transition.
The impact of social media interventions on adult influenza vaccination: A systematic review
Authors: Mujong Datapwa , Rogers Eleanor , Heffernan Catherine 
Published: January 2024

This article was sponsored by CSL Seqirus. CSL Seqirus had no involvement in the writing or editorial process of this article. Background Despite recent interest around the impact of social media on COVID-19 vaccine uptake, there has not been a review of social media and adult ‘flu vaccinations. This review aims to look at whether social media interventions can improve ‘flu vaccine knowledge, intention to vaccinate and increase vaccine uptake. Methods We conducted a rapid systematic review of controlled intervention and observational studies that used existing social networks on commercial platforms, such as Facebook and Twitter. Findings Eight studies met our inclusion criteria. Due to heterogeneity in design, studies were thematically analyzed. Employment of influencers, multi-tasking, and the use of a verified source for information can impact positively on vaccine knowledge and intention to vaccinate. Interactions with postings tended to reinforce preconceived ideas. Conclusion Social media interventions can help to improve knowledge about ‘flu vaccine and intention to vaccinate but access to services remain a better determinant of vaccine uptake.
Identification and validation of a new prognostic signature based on cancer-associated fibroblast-driven genes in breast cancer
Authors: Wu Zi-Zheng , Wei Yuan-Jun , Li Tong , Zheng Jie , Liu Yin-Feng , Han Meng 
Published: January 2024

BACKGROUND
Breast cancer (BC), a leading malignant disease, affects women all over the world. Cancer associated fibroblasts (CAFs) stimulate epithelial-mesenchymal transition, and induce chemoresistance and immunosuppression.
AIM
To establish a CAFs-associated prognostic signature to improve BC patient outcome estimation.
METHODS
We retrieved the transcript profile and clinical data of 1072 BC samples from The Cancer Genome Atlas (TCGA) databases, and 3661 BC samples from the The Gene Expression Omnibus. CAFs and immune cell infiltrations were quantified using CIBERSORT algorithm. CAF-associated gene identification was done by weighted gene co-expression network analysis. A CAF risk signature was established via univariate, least absolute shrinkage and selection operator regression, and multivariate Cox regression analyses. The receiver operating characteristic (ROC) and Kaplan-Meier curves were employed to evaluate the predictability of the model. Subsequently, a nomogram was developed with the risk score and patient clinical signature. Using Spearman's correlations analysis, the relationship between CAF risk score and gene set enrichment scores were examined. Patient samples were collected to validate gene expression by quantitative real-time polymerase chain reaction (qRT-PCR).
RESULTS
Employing an 8-gene (IL18, MYD88, GLIPR1, TNN, BHLHE41, DNAJB5, FKBP14, and XG) signature, we attempted to estimate BC patient prognosis. Based on our analysis, high-risk patients exhibited worse outcomes than low-risk patients. Multivariate analysis revealed the risk score as an independent indicator of BC patient prognosis. ROC analysis exhibited satisfactory nomogram predictability. The area under the curve showed 0.805 at 3 years, and 0.801 at 5 years in the TCGA cohort. We also demonstrated that a reduced CAF risk score was strongly associated with enhanced chemotherapeutic outcomes. CAF risk score was significantly correlated with most hallmark gene sets. Finally, the prognostic signature were further validated by qRT-PCR.
CONCLUSION
We introduced a newly-discovered CAFs-associated gene signature, which can be employed to estimate BC patient outcomes conveniently and accurately.
Monomorphic epitheliotropic intestinal T-cell lymphoma with bone marrow involved: A case report
Authors: Zhang Fen-Juan , Fang Wen-Juan , Zhang Cang-Jian 
Published: January 2024

BACKGROUND
Monomorphic epithelial intestinal T-cell lymphoma (MEITL) is a rare type of peripheral T-cell lymphoma. The clinical manifestations are diarrhea, abdominal pain, perforation and an abdominal mass.
CASE SUMMARY
We present a 52-year-old female patient who was diagnosed with MEITL. Further disease progression was observed after multiline chemotherapy. Eventually, the patient died of a severe infection.
CONCLUSION
MEITL is a rare intestinal primary T-cell lymphoma with aggressive behavior, a high risk of severe life-threatening complications, and a poor prognosis.
Individualized anti-thrombotic therapy for acute myocardial infarction complicated with left ventricular thrombus: A case report
Authors: Song Yan , Li Hua , Zhang Xia , Wang Lei , Xu Hong-Yan , Lu Zhi-Chao , Wang Xiao-Gang , Liu Bo 
Published: January 2024

BACKGROUND
Presently, there is no established standard anti-blood clot therapy for patients facing acute myocardial infarction (AMI) complicated by left ventricular thrombus (LVT). While vitamin K antagonists are the preferred choice for oral blood thinning, determining the best course of blood-thinning medication remains challenging. It is unclear if non-vitamin K antagonist oral blood thinners have different effectiveness in treating LVT. This study significantly contributes to the medical community.
CASE SUMMARY
The blood-thinning treatment of a patient with AMI and LVT was analyzed. Triple blood-thinning therapy included daily enteric-coated aspirin tablets at 0.1 g, daily clopidogrel hydrogen sulfate at 75 mg, and dabigatran etexilate at 110 mg twice daily. After 15 d, the patient’s LVT did not decrease but instead increased. Clinical pharmacists comprehensively analyzed the cases from the perspective of the patient’s disease status and drug interaction. The drug regimen was reformulated for the patient, replacing dabigatran etexilate with warfarin, and was administered for six months. The clinical pharmacist provided the patient with professional and standardized pharmaceutical services. The patient’s condition was discharged after meeting the international normalized ratio value (2-3) criteria. The patient fully complied with the follow-up, and the time in the therapeutic range was 78.57%, with no serious adverse effects during pharmaceutical monitoring.
CONCLUSION
Warfarin proves to be an effective drug for patients with AMI complicated by LVT, and its blood-thinning course lasts for six months.
La presencia del miedo y la construcción de enemigos en el discurso de Vox en 2019
Authors: Bretones María Trinidad , Domínguez Martí Miquel 
Published: January 2024

El tipo y los temas que se emplean en los discursos de los partidos políticos de extrema derecha configuran, sin duda, algunos de sus rasgos más visibles. El autoritarismo, el rechazo a la inmigración, o la crítica destructiva hacia las instituciones del Estado y a hacia el resto de partidos políticos son algunos de los temas que los caracterizan. Asimismo, parece que el elemento que más identifica a este discurso es su elevado contenido emocional y, más concretamente, la alta intensidad en el uso de mensajes que activan miedo en la población receptora.
Esta investigación rastrea la presencia del miedo en los discursos del partido político español de extrema derecha, Vox. Mide su intensidad, recoge los términos con los que se designa y muestra, además, su asociación con el proceso discursivo de construcción de enemigos. En concreto, para medir la intensidad y seleccionar y cuantificar los términos del discurso del miedo se exploran, durante el año 2019, los mensajes en la cuenta Twitter de este partido, y se compara, durante el mismo año, con la presencia de mensajes de temor o miedo en las cuentas de la red oficial equivalente del resto de partidos políticos
Photonic crystal nanolasers in polydimethylsiloxane thin film for sensing quantities leading to strain
Authors: Lu Tsan-Wen , Lin Kuang-Ming , Wang Zhen-Yu , Lee Po-Tsung 
Published: January 2024

We propose and realize a 1D photonic crystal nanocavity laser embedded in a polydimethylsiloxane (PDMS) thin film. The nanolaser in PDMS exhibits a significant optical response to structural deformation. It can be attached to object surfaces or integrated into different configurations, enabling the detection of different quantities that induce strain in the film. In experiments, this nanolaser can detect temperature variations or micrometer-scale bending degrees by attaching it to a temperature-controllable or bendable plate, respectively. Moreover, we further utilize the film as a diaphragm of a chamber to demonstrate its potential as a highly sensitive pressure gauge and chemical sensor. By adjusting the thickness of the PDMS thin film and the position of the nanolaser, we experimentally achieved a minimum detectable gas pressure variation of 0.12 kPa and a sensing dynamic range of 46 dB. We also investigate the optical response of the nanolaser to the swelling of the PDMS thin film induced by different organic solvents in experiments. The experimental wavelength shift rates over time are proportional to different chemical vapors’ PDMS swelling ratios, which can be used to identify specific chemical vapors within the chamber that induce PDMS swelling. Based on the experimental results and the capability of reattaching to different objects or configurations, we believe that our PhC nanolaser demonstrated herein holds significant potential as a highly sensitive mechanical and chemical sensor.