bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi In Silico Senyawa dalam Daun Kelor (Moringa oleifera L.) sebagai Inhibitor Protein Kinase C Alpha pada Kanker Payudara
Authors: Salsabila Annisa Siti , Safira Rayhan Zarra , Nugraha Arif Rizki , Wulandari Dinda , Qaivani Ridhatul , Sari Wuri Ariestika 
Published: February 2024

Kanker payudara merupakan salah satu jenis tumor ganas yang timbul akibat meningkatnya pertumbuhan sel secara abnormal pada epitel duktus maupun lobulus di jaringan payudara. Migrasi sel kanker payudara dapat diinisiasi oleh meningkatnya ekspresi protein kinase C alpha sehingga menginduksi terjadinya potensi invasif sel kanker payudara dan menyebabkan metastasis. Senyawa Fenolik dalam daun kelor (Moringa oleifera) berpotensi untuk menginduksi apoptosis dengan menghambat jalur pensinyalan yang diinisiasi oleh protein kinase C alpha. Tujuan dari penelitian ini untuk mengetahui mekanisme inhibisi pada protein kinase alpha dari senyawa yang terkandung di dalam daun kelor (Moringa oleifera) secara in silico menggunakan simulasi penambatan molekuler. Tahapan penelitian terdiri atas preparasi dan optimasi protein kinase C alpha serta senyawa uji, validasi metode dan simulasi penambatan molekuler melalui program AutoDockTools 1.5.6, pemodelan farmakofor melalui program LigandScout, serta prediksi profil farmakokinetika dan ADMET berdasarkan parameter Lipinski’s Rule of Five melalui situs pre-ADMET. Hasil dari simulasi penambatan molekuler tersebut kemudian divisualisasikan melalui program BIOVIA Discovery Studio 2020 Client. Dari hasil simulasi penambatan molekuler diperoleh 3 senyawa yang memiliki nilai binding energy paling rendah dan konstanta inhibisi paling kecil yaitu myricetin (∆G = -8,49 kcal/mol; Ki = 600,42 nM), kuersetin (∆G = -7,94 kcal/mol; Ki = 1,52 uM), dan kaempferol (∆G = -7,75 kcal/mol; Ki = 2,08uM). Namun, hanya kaempferol yang memiliki sifat absorpsi pada usus serta permeabilitas yang lebih baik dibandingkan dengan myricetin dan kuersetin. Oleh karena itu, pada penelitian ini menunjukkan bahwa senyawa kaempferol berpotensi untuk dijadikan senyawa kandidat sebagai obat antikanker payudara melalui mekanisme inhibisi protein kinase C alpha.
Penerapan Tanaman Hidroponik Untuk Membangun Kemampuan Dalam Meningkatkan Ketahanan Pangan Didesa Karangpatihan
Authors: Najib M. Thoha Ainun , Rugmana Poppy Ardianti , Sabella Prika Wahyu , Kholila Q.F. Rifa Nur 
Published: February 2024

Program Sosialisasi dan Pelatihan ini dapat meningkatkan kemampuan dan kreatifitas masyarakat khususnya kelompok tani dalam bercocok tanam dengan menggunakan lahan yang tidak terlalu luas. Salah satu dari tujuan yang paling utama dalam kegiatan yaitu dapat meningkatkan kesadaran yang mampu dan ketahanan pangan masyarakat melalui penanaman sayuran hydroponik dengan memanfaatakan daur ulang limbah botol plastik untuk wadah media penanaman. Sistem hidroponik tersebut berbasis ramah lingkungan. KPM ini dilakukan dengan metode (ABCD) Asset Based Community Development dengan menggunakan asset untuk mengembangkan potensi sebagai kekuatan yang dimiliki komunitas. Dalam kegiatan penanaman sayuran hidroponik ini melibatkan kelompok tani serta masyarakat umum dari 4 RT/RW Dusun Krajan, Desa Karangpatihan. Kegiatan ini mampu meningkatkan kemampuan dan pengarahan kepada kelompok tani melalui pelatihan pembuatan sistem hidroponik sederhana dengan menggunakan botol plastik sebagai media tanam, yang dapat menghasilkan sayuran hidroponik dengan kualitas yang baik. Setelah pelatihan berlangsung diharapkan masyarakat dapat mengolah limbah menjadi bahan daur ulang agar tidak terjadi pencemaran lingkungan. Selain itu juga membantu mengurangi permasalahan ekonomi.
Single-dose nonsteroidal anti-inflammatory drugs in horses have no impact on concentrations of cytokines or growth factors in autologous protein solution and platelet-rich plasma
Authors: Brown Kara A. , Gregorio Elizabeth N. , Barot Dhvani , Usimaki Alexandra , Linardi Renata L. , Missanelli Jaclyn R. , You Youwen , Robinson Mary A. , Ortved Kyla F. 
Published: February 2024

Abstract

OBJECTIVE
To determine the effects of a single dose of the NSAIDs phenylbutazone, firocoxib, flunixin meglumine, and ketoprofen on concentrations of growth factors and cytokines in autologous protein solution (APS) and platelet-rich plasma (PRP).

ANIMALS
6 adult university-owned horses.

METHODS
For the first phase, 6 horses were randomized to receive ketoprofen (1,000 mg) or flunixin meglumine (500 mg) IV. Blood was obtained and processed for APS (Pro-Stride) and PRP (Restigen) before and 6 hours after administration of NSAIDs. Horses underwent a 2-week washout period, after which the protocol was repeated using a crossover design. For the second phase, following at least a 2-week washout period, the study protocol was repeated with phenylbutazone (1 g) or firocoxib (57 mg) administered orally. Plasma was collected 6 hours after administration for evaluation of drug concentrations, and APS and PRP were analyzed for concentrations of drug, platelets, leukocytes, and several growth factors and cytokines (PDGF, fibroblast growth factor, TGF-β1, IL-1β, IL-10, IL-6, IL-8, and tumor necrosis factor-α) before and 6 hours after administration of NSAIDs using immunoassays.

RESULTS
There were no significant differences in concentrations of cytokines or growth factors before or after administration of any NSAID. There were significant differences in concentrations of leukocytes and platelets based on both product and time. NSAID concentrations in plasma were not significantly different from concentrations in APS and PRP.

CLINICAL RELEVANCE
These results help guide clinicians on the appropriate use of these NSAIDs in conjunction with the processing of APS and PRP, which is unlikely to significantly alter the final product after single-dose administration.
One-week sorghum (Sorghum bicolor L.) grain consumption is insufficient to increase adiponectin levels in prediabetic adults
Authors: Mudjanarko Sony Wibisono , Rahardjo Teguh , Soelistijo Soebagijo Adi , Rahmawati Siti 
Published: February 2024

Abstract

Objective. Adiponectin is an internally produced bioactive compound with a protective role against the insulin resistance-related diseases. Finding an adiponectin modifier can play a beneficial role in preventing the progression of the diseases, particularly in the prediabetic patients, as a high-risk population. This study was undertaken to examine the effect of dietary sorghum grain for a week on the plasma adiponectin levels in prediabetic patients.

Methods. The study involved 26 (13+13) participants in both control and intervention groups. The control group maintained their habitual diet of white rice, while the intervention group replaced their habitual diet of white rice with sorghum grain for seven consecutive days. In all participants, the adiponectin concentration was measured before and after the intervention period.

Results. Most study subjects had central obesity and dyslipidemia. Adiponectin levels after the intervention period decreased from the baseline in the control and sorghum groups including in all BMI groups. The change of decreasing adiponectin level was greater in the control than the sorghum group and in line with greater BMI in the sorghum group, but statistically insignificant. No significant difference in adiponectin concentrations was found among BMI groups.

Conclusion. Sorghum grain consumption for a week is insufficient to increase adiponectin levels in the prediabetic patients. Insulin resistance, central obesity, and dyslipidemia may be the confounding variables that alter the favorable effect of sorghum on adiponectin. Longer sorghum consumption or other interventions may be needed to increase the adiponectin levels in people under these conditions.
Risk of malignancy in Thy3 thyroid nodules
Authors: Rezkallah Emad Mofid Nassif , Hanna Ragai Sobhi , Elsaify Wael Magdy 
Published: February 2024

Abstract

Objective. Thyroid cancer is the most common endocrine malignancy in humans. Ultrasound guided fine needle aspiration cytology (FNAC) is now considered the best diagnostic tool for the evaluation of any thyroid nodule. Thyroid cytology is graded from Thy1 to Thy5 with Thy3 being the most challenging in diagnosis. Our aim was to identify the risk of malignancy in Thy3 cytology in our centre. This risk should be explained to the patient before taking any decision.

Methods. One hundred and one patients were included in our study. All patients had Thy3 cytology on preoperative ultrasound scan guided FNAC. All patients had diagnostic hemithyroidectomy. The results from the histology were compared with the cytology findings and the rates of malignancy were identified.

Results. Of the 101 patients, 17 were males and 84 females. Average age for diagnosis was 52.4±15 years of age. Patients were classified into three groups; patient who had completely benign histology (n=70), patients who had incidental finding of micro-carcinoma after diagnostic hemithyroidectomy (n=10), and patients who had thyroid macro-carcinomas (n=21). Total rate of malignancy was 30.7% when combining both the malignant and the incidental groups and 20.8% when excluding the incidental group.

Conclusion. Our rates of malignancy in Thy3 cytology are similar to the literature. These rates should be explained clearly to the patient during the preoperative counselling. Future advances in biomarkers technology may help to improve the preoperative diagnostic accuracy and reduce the rate of unnecessary thyroid surgery.
The Magnitude of the Soret Force on Colloidal Particles Measured in Microgravity
Authors: Lynch Matthew L. , Kodger Thomas E. , Palacio-Mancheno Paolo , Pestak Mark W. , Meyer William V. 
Published: February 2024

Abstract
There is a broad interest in both industry and academe in understanding the time-evolution in the microstructure of colloidal gels, as such changes affect the properties of the gels including product self-life and rheology. In colloidal gels, the time-evolution results from the magnitude and the relative proportions of forces—including gravity, acting on the colloidal particles. The aim of this study was to measure the magnitude of the Soret force acting on the colloidal particles in a model gel in the microgravity on the International Space Station, as a proxy for gravitational forces in Earth-based experiments. It was found that the Soret force could be used to create an effective gravitational force of between about 10 × 10−17 N (3 milli-G) and 3 × 10−17 N (1 milli-G) on the colloidal particles, where the lower limit is set by the dominance of particle flux from Brownian forces. These results should allow mapping the behavior of colloidal gels broadly described in literature on other gels—such as polymer gels of industrial interest, where the colloidal particles are much smaller.
Development of New Bio-Based Building Materials by Utilising Manufacturing Waste
Authors: Argalis Pauls P. , Sinka Maris , Andzs Martins , Korjakins Aleksandrs , Bajare Diana 
Published: February 2024

Abstract
Over the last decade, research has increasingly focused on reducing the use of natural resources and improving waste management in the construction industry. Various possibilities exist for reducing waste in this sector, ranging from using waste as filler materials to developing new binders and building materials. This study focuses on the development of bio-based building materials using waste from the manufacturing of wood-wool cement boards. The binder and filler materials were obtained from the manufacturing waste and used in this research. The developed materials were tested for their visual appearance, macrostructure, material density, thermal conductivity coefficient and compressive strength. The results showed promising data for the self-bearing bio-based building materials, which had similar thermal properties to other bio-based materials and could be used as thermal insulation materials with a thermal conductivity coefficient of 0.0827–0.1172 W/(mK). The material density of the developed bio-based composites was found to be 430–617 kg/m3. By incorporating manufacturing waste into the production process of bio-based building materials, it becomes evident that overall waste from manufacturing plants can be significantly reduced, and the sustainability aspect of wood-cement board manufacturers can be enhanced.
Comparative analysis of the conceptual features of the concepts of YOUTH and JUVENTUD in Russian and Spanish linguistic cultures
Authors: Safaralieva Lyubov Aleksandrovna , Tutova Ekaterina Vladimirovna , Shevchenko Valentina Artemovna 
Published: February 2024

In modern linguistics, research is actively developing aimed at cognizing the surrounding reality, verbalized by linguistic units of a particular language. At the same time, of course, interdisciplinary research, including both linguistic and extralinguistic data, is of particular value. The relevance of our article is the comparison of the concepts of YOUTH and JUVENTUD as fragments of the linguistic picture of the world of the Russian-speaking and Spanish-speaking peoples based on the synthesis of linguocultural and linguocognitive approaches to the study of concepts. The purpose of the work is to identify and compare the conceptual features of the above-mentioned concepts in Russian and Spanish linguistic cultures based on lexicographic sources and using extralinguistic socio-demographic data. The results obtained can find practical application in lexicographical activity. In our study, the conceptual features of the concepts of YOUTH and JUVENTUD were reconstructed based on the data of explanatory, encyclopedic, etymological dictionaries of the Russian and Spanish languages. The conceptual features of the mentioned concepts were identified by understanding the semantic scope of the names of the concepts: the lexemes youth, young in Russian and juventud, joven – in Spanish. Despite the fact that the concept of YOUTH was previously the subject of scientific analysis in the works of Russian linguists, a comparative study of the conceptual features of the concepts of YOUTH and JUVENTUD in Russian and Spanish linguistic cultures has not been conducted before, which is the novelty of the article. It was revealed that the coinciding conceptual features include: 1) a certain life stage of a person between adolescence and adulthood; 2) characteristic of youth; 3) the first stage of life / existence (about an animal, plant, phenomenon); 4) younger in age or time. It was also found that the period of youth for speakers of Spanish linguoculture covers a greater number of years, compared with the same period in Russian linguoculture, which is due to extralinguistic factors – a longer life expectancy in a Spanish-speaking society. In addition, for native Russian speakers, YOUTH is often associated with ‘immaturity, weakness’, while in Spanish linguoculture JUVENTUD is perceived as a period of ‘flourishing, strength, energy'.
A Study to Assess the Burden of Hematological Malignancies at a Tertiary Care Center
Authors: Pai Vinayak , Gite Pramod , Joshi Kavita , Mulkalwar Alhad , Kate Vikram 
Published: February 2024

Objectives
Hematological malignancies place a significant financial and medical burden on the affected patients. Well-equipped oncology centers providing healthcare for these patients are also sparse. By studying the epidemiology of those diagnosed with hematological malignancies, it can be correlated with the outcomes and compared with global and national trends. This will allow healthcare decision-makers at all levels to make informed decisions, while allocating resources to combat hematological malignancies. This study is aimed at understanding the pattern of various hematological malignancies presenting at a tertiary care center including their clinical profile, risk factors, etiology and presentation.

Material and Methods
This was an observational prospective study conducted in King Edward Memorial Hospital, Mumbai, India. Patients aged 12 years and above suffering from hematological malignancies were recruited from the medical wards. The history and systemic examination findings were recorded from patients’ records. The patients were treated as per the discretion of the treating physician and all investigations advised by the treating physician were noted in the respective case record forms.

Results
The maximum cases were from the age group 36–50 years, i.e., 32 in number (40%), followed by the age group 51–65 years (25%). A greater number of male patients were encountered than female ones (67.5% vs 32.5%). Most of the patients were unskilled laborers followed by semi-skilled workers. Pesticide exposure was the commonest etiological factor reported in 16 (20%) patients, followed by exposure to silica that was reported in nine patients (11.25%).

Conclusion
The common age group to encounter hematological malignancies in patients is 36–50 years, being more prevalent among males. History of exposure to risk factors such as pesticides is commonly seen. Factors such as age and family history do not correlate with the outcome. Females tend to have a better outcome than males.
“Falsehood” in the Name of Beauty: Musica Ficta in 14th-Century Compositions
Authors: Сундукова Л.И. 
Published: February 2024

Статья посвящена проблеме musica ficta (хроматики) в старинной музыке. Фокус сосредоточен на конкретном временнóм этапе — XIV веке (в Италии и Франции), когда хроматика начинает активно проникать в многоголосие. В одних случаях хроматика фиксировалась специальными знаками в рукописях, в иных — понималась контекстуально. Последнее обстоятельство приводит к тому, что современные редакторы, осуществляющие транскрипции, и исполнители вынуждены самостоятельно принимать решение о расстановке акциденций. Анализируется ряд трактатов XIV века (Просдочимо де Бельдоманди, Уголино Орвиетского, Якоба Льежского и других), в которых идет речь о хроматике: ее происхождении, правилах и причинах введения. При этом цель исследования заключается не столько в том, чтобы суммировать руководства теоретиков прошлого на предмет musica ficta, сколько в анализе современной практики. Он, в свою очередь, показывает, что исполнители прибегают к различным стратегиям, в некоторых случаях внемля заветам музыкантов прошлого, в иных — избирая собственный путь. Но все же, при любых сценариях, они завершают прежде завершенное, создавая новый звуковой облик композиции.
The article is devoted to the problem of musica ficta (accidentals) in early music. The focus is on a specific time period — the 14th century (in Italy and France), when chromatics begins to actively penetrate polyphony. In some cases, accidentals were fixed by special signs in manuscripts, in others they were understood in context. The latter circumstance leads to the fact that modern editors, transcribers and performers are forced to make their own decisions about the arrangement of accidents. The author analyzes a number of treatises of the 14th century (Prosdocimo de’ Beldomandi, Ugolino of Orvieto, Jacob of Liege, and others), dealing with chromatics: its origins, rules, and reasons to use them. At the same time, the purpose of the study is not so much to summarize the guidelines of the theorists of the past on the subject of musica ficta, but to analyze modern practice. It, in turn, shows that performers resort to various strategies, in some cases heeding the precepts of the musicians of the past, in others choosing their own path. But, nevertheless, in any scenarios, they complete what was previously completed, creating a new, unique sound image of the composition.
The Genesis of the Scientific School of Accounting of Nizhny Novgorod State University Named After N. I. Lobachevsky in the System of Development of Economic Knowledge
Authors: Mizikovskii I. E. 
Published: February 2024

Accounting science, as well as science in general, is in constant development and search for new forms, methods and concepts that are immanently embedded in the system of improving economic management. The purpose of the article is to scientifically argue the relevance of accounting knowledge as an integral part of economics on the example of the genesis of the scientific school of Doctor of Economics, Professor E. A. Mizikovsky. The results of accounting and analytical studies play a significant role in structuring the information and instrumental space of corporate management of business entities; in the development of managerial, production and tax accounting; in the formation of a scientific basis for audit and internal control; allow you to create a solid methodological basis for accounting (financial) accounting and auditing standards, strategies for their incorporation into advanced management practices. A significant achievement of scientific accounting thought is the successful development and widespread implementation of the Accounting Plan and Instructions for its application, flexibly adapted to the complex realities of economic life, the needs of public and corporate governance. In the course of the research, methods of historicism, structural-functional and systemic types of analysis were used; formalization, interpretation, evaluation and systematization of scientific data; a causal approach was applied. The article reflects the contribution of the scientific accounting school of Nizhny Novgorod State University named after N. I. Lobachevsky to the development of accounting and the formation of accounting science as a key, formative element of the system of economic knowledge and a catalyzing factor in the development of corporate management of enterprises.
Pengaruh Circuit Training dan Kadar Oksigen dalam Minuman Terhadap Nilai VO2MAX
Authors: Aliriad Hilmy , Adi S , Hudah Maftukin , Apriyanto Rohmad , Da'i Mohamad 
Published: February 2024

This study aims to determine the effect of Circuit Training and oxygen levels in beverages on the VO2 MAX value of Rugby SME students. The sample used in this study amounted to 10 students of Rugby SMEs. The instrument in this study used the bleep test. The results of the analysis showed that there was a significant difference between the VO2 MAX value before and after the Circuit Training and the provision of beverages with high oxygen levels with data t-count value of 5.15 is greater than the T-table value of 1,833. This means that the difference in average VO2 MAX before and after exercise can be said to be significant with a significant level of 0.5%. The results of data analysis showed a significant effect between Circuit Training and the provision of drinks with high oxygen levels to the value of VO2 MAX Rugby UKM students. The conclusion of this study shows that Circuit Training exercises and oxygen levels in drinks have a positive and significant impact on increasing VO2 MAX Rugby UKM students, with a significant level of 0.5%. T-count values greater than T-table values prove the existence of strong evidence to state significant differences between VO2 MAX before and after exercise.