bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum vitamin C status of people in New South Wales: retrospective analysis of findings at a public referral hospital
Authors: Bhattacharyya Puja , Schemann Kathrin , Min San San , Sullivan David R , Fuller Stephen J 
Published: October 2023

AbstractObjectivesTo examine the relationship between vitamin C status and demographic factors in New South Wales on the basis of serum vitamin C test results undertaken at the central pathology laboratory in Sydney, and to assess associations with age, gender, social disadvantage, and geographic remoteness.Design, settingRetrospective observational study; analysis of vitamin C test results undertaken at the Royal Prince Alfred Hospital, 1 January 2017 – 31 December 2021.Main outcome measuresVitamin C status (normal, serum concentration ≥ 40 μmol/L; hypovitaminosis C, 12–39 μmol/L; significant deficiency, < 12 μmol/L); associations of vitamin C status with year of testing, age, gender, socio‐economic status (Index of Relative Socio‐Economic Advantage and Disadvantage quintile), and geographic remoteness (Australian Statistical Geography Standard); rate of hypovitaminosis C or significant deficiency test results (relative to findings of normal levels; per 100 000 estimated resident population) by Statistical Area 3.ResultsOf 17 507 vitamin C tests undertaken during 2017–2021, 4573 were excluded (multiple tests for individuals); of 12 934 included results, 6654 were for women (51.5%), 9402 for people living in major cities (73.5%), and 81 for people in remote or very remote areas (0.6%). In multivariable multinomial regression analyses, significant deficiency (relative to normal test results) was more likely for men than women (adjusted odds ratio [aOR], 1.39; 95% confidence interval [CI], 1.27–1.52); the likelihood of hypovitaminosis C (IRSAD quintile 1 v 5, aOR, 1.35; 95% CI, 1.19–1.53) or significant deficiency (aOR, 2.07; 95% CI, 1.79–2.40) generally increased with postcode‐level socio‐economic disadvantage. Several of the population areas with the highest low vitamin C rates were areas of greatest disadvantage in NSW.ConclusionsThe prevalence of vitamin C deficiency among older people and people living in areas of socio‐economic disadvantage indicates that population assessment of vitamin C levels would be appropriate.
Prospective Applications of Microwave Reflectarray Antennas to the Design and Fabrication of Future Radio Telescopes
Authors: Olmi Luca 
Published: October 2023

The size, cost, and complexity of radio telescopes and their instrumentation have grown enormously during the last few decades. The vast majority of new technology employed by radio astronomy has been developed for the industrial market, and the technology in use by today’s best radio telescopes is 20 to 30 years old. In particular, the antenna technology has changed very slowly, and thus, an important question is whether novel antenna technologies might bring down the cost of collecting area, since efficiency and accuracy compromises become much more costly for large radio telescopes. In this chapter, we discuss the strengths and weaknesses of specific new technologies, and in particular reflectarrays, which have been developed mainly for remote sensing and satellite communications, that might lead to a great leap forward in the design and fabrication of antennas for radio astronomy.
Photonic crystal-based decoders: ideas and structures
Authors: Javad Maleki Mohammad , Soroosh Mohammad , Parandin Fariborz , Haddadan Fatemeh 
Published: October 2023

Recent developments in photonic crystal structures have enabled the implementation of optical decoders which possess superior features such as high contrast ratio and fast response. According to published reports, photonic crystal-based decoders exhibit contrast ratios higher than 20 dB and a response time as fast as 200 fs, making them an ideal candidate for high-speed processing applications. Resonant cavities and rings can be utilized to drop waves with high efficiency, thereby simplifying circuits and reducing the need for cross-connections. In this chapter, we provide an introduction to the decoding operation and its importance in various applications, followed by a discussion of fundamental features of photonic crystals such as photonic bandgap and the optical Kerr effect. We also consider the role of resonance in photonic crystals and present recent ideas and designed structures for the benefit of readers.
Pengaruh Kecerdasan Logika Matematika Terhadap Kemampuan Pemahaman Konsep Siswa Dalam Pembelajaran Matematika di MI Miftahul Ulum Pandanarum
Authors: Fauzi Akhmad , Rohmah Yushinta Lailatul 
Published: October 2023

In the context of competitive education, enhancing the quality of human resources through education is of utmost importance. The diverse intelligence of humans is widely recognized, aligning with the multiple intelligences theory proposed by Howard Gardner. However, the results of the 2018 PISA assessment reveal a low level of mathematical proficiency among Indonesian students, highlighting the urgent need to understand the factors influencing this ability.
This article focuses on the role of mathematical logical intelligence as a key factor in understanding mathematical concepts. The aim of this study is to identify the influence of mathematical logical intelligence on students' understanding of mathematical concepts at MI Miftahul Ulum Pandanarum. The research method used is an associative approach with a quantitative approach, and data were collected through a questionnaire on mathematical logical intelligence and a test of conceptual understanding ability. The research sample consisted of 120 students. The data were analyzed using simple linear regression. Based on the results of this research, an R-squared value of 0.083 (83%) indicates that mathematical logical intelligence has an influence on students' understanding of concept abilities, while 17% is influenced by other variables. The t-test results reveal that the calculated t-value of 3.266 is greater than the tabulated t-value of 1.981, leading to the conclusion that there is a significant influence between the mathematical logical intelligence variable (X) and the concept comprehension ability variable (Y). With a significance value (Sig.) of 0.001 < 0.05, the alternative hypothesis Ha is accepted, and the null hypothesis Ho is rejected.
IS THERE HOPE FOR CREATIVE WRITING IN OUR EFL CLASSROOMS?
Authors: Candanedo Wilmo 
Published: October 2023

Creative writing must have a place in the English as a Foreign Language [EFL] classroom at Universidad Tecnológica Oteima.
Timing, disbelief, and curricula have been keeping us from allowing creativity and imagination to sculpt the process of writing of our students. Even though we must be faithful to the teaching of the mechanics and style of writing, we owe our students the opportunity to express their inward journeys when they write. As a result, when writting becomes a conduit to articulate the endless struggle to live, learning a second language is no longer an ongoing proof of linguistic competence, but some pedagogy to human development. In short, language learning, first and second, becomes an authentic translator of what is growing, cognitively and affectively, in our restless hearts. Surely, there must indeed be hope for creative writting in the EFL classroom.
ทำไมจึงไม่ค่อยมีทฤษฎีเศรษฐกิจการเมืองจากฐานองค์ความรู้ทางวิชาการในโลกที่สาม?” : การครอบงำและการเลือกปฏิบัติทางวิชาการจากความรู้แบบสำนักยุโรปเป็นศูนย์กลาง
Authors: หวังสัจจะโชค วีระ 
Published: October 2023

บทความนี้เริ่มต้นจากการตอบคำถามที่ว่า “ทำไมจึงไม่ค่อยมีทฤษฎีเศรษฐกิจการเมืองจากฐานองค์ความรู้ทางวิชาการในโลกที่สาม” โดยข้อถกเถียงหลักในการตอบคำถามใช้กรอบการศึกษาแบบประวัติศาสตร์นิพนธ์ว่าด้วยระเบียบการศึกษา เพื่ออธิบายว่าองค์ความรู้ทางเศรษฐกิจการเมืองในฐานะ “ทฤษฎี” ถูกครอบงำโดยกลุ่มสำนักยุโรปเป็นศูนย์กลางตั้งแต่ช่วงศตวรรษที่ 18 ถึง 19 ทั้งในด้านของทฤษฎีฝั่งเสรีนิยมและมาร์กซิสต์ ต่างมีชุดคำอธิบายจากยุโรปเป็นศูนย์กลางและอ้างว่าคำอธิบายดังกล่าวมีความเป็นสากล ทั้งในระดับความเป็นศาสตร์ด้วยวิธีวิทยาต่างๆแบบเสรีนิยม และแบบแผนการพัฒนาการทางประวัติศาสตร์แบบมาร์กซิสต์ จึงนำมาสู่การการเลือกปฏิบัติและการเหยียดชนชั้นทางวิชาการต่อฐานองค์ความรู้ทางเศรษฐกิจการเมืองนอกสำนักยุโรป ทั้งขอบเขตการศึกษา ทรัพยากรทางวิชาการ และการลดทอนคุณค่าของการศึกษานอกพื้นที่ยุโรปให้เป็นเพียงอาณาบริเวณศึกษา อย่างไรก็ดี การศึกษาเศรษฐกิจการเมืองบนฐานนอกสำนักยุโรปในกลุ่ม “การเมืองชีวิตประจำวัน” ได้ขึ้นมาท้าทายองค์ความรู้ที่ครอบครอบอำนาจนำในทางทฤษฎีได้
Study of Air Pollution by NOx from Petrol Fuels at Four Stations in Dakar–Senegal by Determining Nitrogen Content
Authors: Kane Amadou , Samb Issa , Ndiaye Cheikh Ahmed Tidiane , Diouf Silver Boucar , Ndiaye Saloly , Ly Seydina Cheikhou Omar , Gaye Mohamed Lamine 
Published: October 2023

NOX emissions are a health hazard, and are increasingly regulated in cars. NOx also contributes to the formation of acid rain and the eutrophication of ecosystems. Nitrogen oxides are a family of molecules including nitrogen monoxide (NO) and nitrogen dioxide (NO2). These gases are formed in the engine during high-temperature fuel combustion, and play a role in the formation of fine particles in ambient air. In this article, the aim is to determine the nitrogen content of gasoline samples taken at four gasoline stations of the most representative groups in terms of distribution of light petroleum products in order to assess the environmental impact due to greenhouse gas emissions resulting from the use of gasoline by vehicles and to reduce the nitrogen content in the form of nitrogen oxides NOx. After an introduction, we presented the material and the method used, followed by the results of our analyses and a discussion of the results obtained before concluding.
Personalized Initial Screening Age for Colorectal Cancer in Individuals at Average Risk
Authors: Chen Xuechen , Heisser Thomas , Cardoso Rafael , Hoffmeister Michael , Brenner Hermann 
Published: October 2023

ImportanceColorectal cancer (CRC) risk varies widely in the population at average risk without a family history, but there are no established routines for translating this variation into personalized starting ages of screening.ObjectiveTo illustrate derivation of risk-adapted starting ages of CRC screening based on the concept of risk advancement period (RAP) using sex and a polygenic risk score (PRS) as an example.Design, Setting, and ParticipantsThis cohort study included participants in the UK Biobank study recruited in England, Wales, and Scotland between March 13, 2006, and October 1, 2010. Participants were aged 40 to 69 years, with no previous bowel cancer screening and no family history of CRC. Follow-up of cancer data was completed February 29, 2020, for England and Wales and January 31, 2021, for Scotland. The censoring date for death data was September 30, 2021, for England and Wales and October 31, 2021, for Scotland.ExposuresData on age, sex, and family history were collected at the baseline interview. A PRS was calculated based on 139 CRC-related risk loci.Main Outcomes and MeasuresHazard ratios (HRs) of sex and PRS with CRC risk and mortality were estimated using Cox proportional hazards regression models and were translated to RAPs to quantify how many years of age earlier or later men and individuals in higher or lower PRS deciles would reach risks comparable with those of the reference group (ie, women or those in the 5th and 6th PRS deciles).ResultsAmong 242 779 participants (median age, 55 [IQR, 48-61] years; 55.7% women), 2714 incident CRC cases were identified during a median follow-up of 11.2 (IQR, 10.5-11.8) years and 758 deaths during a median follow-up of 12.8 (IQR, 12.0-13.4) years. The HRs of CRC risk were 1.57 (95% CI, 1.46-1.70) for men vs women and ranged from 0.51 (95% CI, 0.41-0.62) to 2.29 (95% CI, 2.01-2.62) across PRS deciles compared with the reference. The RAPs were 5.6 (95% CI, 4.6-6.6) years for men vs women and ranged from −8.4 (95% CI, −11.0 to −5.9) to 10.3 (95% CI, 8.5-12.1) years across PRS deciles compared with the reference deciles. Risk-adapted starting ages of screening would vary by 24 years between men in the highest PRS decile and women in the lowest PRS decile. Similar results were obtained regarding CRC mortality.Conclusions and RelevanceIn this large cohort study including women and men at average risk of CRC, risk-adapted starting ages of screening strongly varied by sex and a PRS. The RAP concept could easily accommodate additional factors for defining personalized starting ages of screening.
ETV5 regulates proliferation and cell cycle genes in the INS‐1 (832/13) cell line independently of the concentration of secreted insulin
Authors: Díaz‐López Yael E. , Pérez‐Figueroa Gloria Erandi , Cázares‐Domínguez Vicenta , Frigolet María E. , Gutiérrez‐Aguilar Ruth 
Published: October 2023

The transcription factor E‐twenty‐six variant 5 (ETV5) regulates acute insulin secretion. Adequate insulin secretion is dependent on pancreatic β‐cell size and cell proliferation, but the effects of ETV5 on proliferation, cell number, and viability, as well as its relationship with insulin secretion, have not been established yet. Here, we partially silenced ETV5 in the INS‐1 (832/13) cell line by siRNA transfection and then measured secreted insulin concentration at different time points, observing similar levels to control cells. After 72 h of ETV5 silencing, we observed decreased cell number and proliferation, without any change in viability or apoptosis. Thus, partial silencing of ETV5 modulates cell proliferation in INS‐1 (832/13) independently of secreted insulin levels via upregulation of E2F1 and of inhibitors of the cyclin/CDKs complexes (p21Cdkn1a, p27Cdkn1b, and p57Cdkn1c) and downregulation of cell cycle activators (PAK3 and FOS).
A Membrane‐Targeted Photosensitizer Prevents Drug Resistance and Induces Immune Response in Treating Candidiasis
Authors: Wu Ming‐Yu , Xu Xiaoyu , Hu Rui , Chen Qingrong , Chen Luojia , Yuan Yuncong , Li Jie , Zhou Li , Feng Shun , Wang Lianrong , Chen Shi , Gu Meijia 
Published: October 2023

AbstractCandida albicans (C. albicans), a ubiquitous polymorphic fungus in humans, causes different types of candidiasis, including oral candidiasis (OC) and vulvovaginal candidiasis (VVC), which are physically and mentally concerning and financially costly. Thus, developing alternative antifungals that prevent drug resistance and induce immunity to eliminate Candida biofilms is crucial. Herein, a novel membrane‐targeted aggregation‐induced emission (AIE) photosensitizer (PS), TBTCP‐QY, is developed for highly efficient photodynamic therapy (PDT) of candidiasis. TBTCP‐QY has a high molar absorption coefficient and an excellent ability to generate 1O2 and •OH, entering the interior of biofilms due to its high permeability. Furthermore, TBTCP‐QY can efficiently inhibit biofilm formation by suppressing the expression of genes related to the adhesion (ALS3, EAP1, and HWP1), invasion (SAP1 and SAP2), and drug resistance (MDR1) of C. albicans, which is also advantageous for eliminating potential fungal resistance to treat clinical infectious diseases. TBTCP‐QY‐mediated PDT efficiently targets OC and VVC in vivo in a mouse model, induces immune response, relieves inflammation, and accelerates the healing of mucosal defects to combat infections caused by clinically isolated fluconazole‐resistant strains. Moreover, TBTCP‐QY demonstrates excellent biocompatibility, suggesting its potential applications in the clinical treatment of OC and VVC.
Enhanced Chemo‐Immunotherapy Strategy Utilizing Injectable Thermosensitive Hydrogel for The Treatment of Diffuse Peritoneal Metastasis in Advanced Colorectal Cancer
Authors: Wang Meng , Hu DanRong , Yang Yun , Shi Kun , Li JiaNan , Liu QingYa , Li YiCong , Li Ran , Pan Meng , Mo Dong , Chen Wen , Li XiCheng , Qian ZhiYong 
Published: October 2023

AbstractPatients with colorectal cancer (CRC) and diffuse peritoneal metastasis (PM) are not eligible for surgical intervention. Thus, palliative treatment remains the standard of care in clinical practice. Systemic chemotherapy fails to cause drug accumulation at the lesion sites, while intraperitoneal chemotherapy (IPC) is limited by high clearance rates and associated complications. Given the poor prognosis, a customized OxP/R848@PLEL hydrogel delivery system has been devised to improve the clinical benefit of advanced CRC with diffuse PM. This system is distinguished by its simplicity, security, and efficiency. Specifically, the PLEL hydrogel exhibits excellent injectability and thermosensitivity, enabling the formation of drug depots within the abdominal cavity, rendering it an optimal carrier for IPC. Oxaliplatin (OxP), a first‐line drug for advanced CRC, is cytotoxic and enhances the immunogenicity of tumors by inducing immunogenic cell death. Furthermore, OxP and resiquimod (R848) synergistically enhance the maturation of dendritic cells, promote the expansion of cytotoxic T lymphocytes, and induce the formation of central memory T cells. Moreover, R848 domesticates macrophages to an anti‐tumor phenotype. OxP/R848@PLEL effectively eradicates peritoneal metastases, completely inhibits ascites production, and significantly prolongs mice lifespan. As such, it provides a promising approach to managing diffuse PM in patients with CRC without surgical indications.
Nanomaterials‐Based Bioinspired Next Generation Wearable Sensors: A State‐of‐the‐Art Review
Authors: Sengupta Debarun , Kottapalli Ajay Giri Prakash 
Published: October 2023

AbstractWith a constantly growing percentage of the population having access to high‐quality healthcare facilities, preventable pathogenic illnesses have been nearly eradicated in the developed parts of the world, which has led to a significant rise in the average human life expectancy over the last few decades. In such a highly developed world, age‐related illnesses will lead to an immense burden on healthcare providers. Remote health monitoring enabled by wearable sensors will play a significant role in the growth and evolution of Health 3.0 by providing intimate and valuable information to healthcare providers regarding the progression of disease in patients with critical life‐altering conditions. Especially, in the case of people suffering from neurodegenerative disorders, inexpensive and user‐friendly wearable sensors can enable physiotherapists monitor real‐time physiological parameters to design patient‐specific treatment plans. This review provides a comprehensive overview of the recent advances and emerging trends at the convergence of biomimicry and nanomaterial sensors, with a specific focus on wearable skin‐inspired mechanical sensors for applications in IoT‐enabled human physiological parameters monitoring. Skin‐inspired wearable mechanical sensors with relevance to the most common types of sensing mechanisms including piezoresistive, piezocapacitive, and triboelectric sensing are discussed along with their current challenges and possible future opportunities.
New insights into protein–polysaccharide complex coacervation: Dynamics, molecular parameters, and applications
Authors: Zheng Jiabao , Van der Meeren Paul , Sun Weizheng 
Published: October 2023

AbstractFor more than a decade, the discovery of liquid–liquid phase separation within living organisms has prompted colloid scientists to understand the connection between coacervate functionality, phase behavior, and dynamics at a multidisciplinary level. Although the protein–polysaccharide was the first system in which the coacervation phenomenon was discovered and is widely used in food systems, the phase state and relaxation dynamics of protein–polysaccharide complex coacervates (PPCC) have rarely been discussed previously. Consequently, this review aims to unravel the relationship between PPCC dynamics, thermodynamics, molecular architecture, applications, and phase states in past studies. Looking ahead, solving the way molecular architecture spreads to macro‐functionality, that is, establishing the relationship between molecular architecture–dynamics–application, will catalyze novel advancements in PPCC research within the field of foods and biomaterials.
Macronutrient composition of milk from captive southern pig‐tailed macaques (Macaca nemestrina)
Authors: Glick Virginia J. , Power Michael L. 
Published: October 2023

AbstractMilk composition is a fundamental aspect of mammalian reproduction. Differences in milk composition between species may reflect phylogeny, dietary ecology, lactation strategy, and infant growth patterns, but may also vary within a species due to maternal body condition. This study presents the first published data on milk macronutrient composition of southern pig‐tailed macaques (Macaca nemestrina) and compares the results with data on two other Cercopithecine species. Milk samples were obtained from five dams at 10‐ and 14‐weeks postparturition. Macronutrient composition was determined at the Smithsonian's National Zoo and Conservation Biology Institute using proven methods developed over 30 years. On average (±SEM), the milk contained 83.9 ± 0.4% water, 6.7 ± 0.4% fat, 7.6 ± 0.1% sugar, 1.8 ± 0.1% protein, and 0.22 ± 0.01% mineral content. The Ca:P ratio was 1.8; concentrations of Ca and protein were correlated. Mean gross energy was 1.02 ± 0.03 kcal/g with most of the energy coming from fat (59.6 ± 1.5%), followed by sugar (29.9 ± 1.4%) and protein (10.5 ± 0.5%). The milks at 14 weeks of infant age were higher in energy than the milks at 10 weeks, with an increase in energy from fat (p = 0.005) and decrease in energy from sugar (p = 0.018). The energy from protein did not change (p = 0.272). Compared to captive rhesus macaque (Macaca mulatta) and olive baboon (Papio anubis) milk assayed by identical methods, captive pig‐tailed macaque milk was higher in energy, but after accounting for the higher milk energy there was no difference in the proportions of milk energy from protein, fat, and sugar. The captive pig‐tailed dams were significantly heavier than reported values for wild pig‐tailed macaques, suggesting high body condition. High body condition in captive Cercopithecines appears to result in milk higher in energy, with more energy coming from fat and less from sugar. However, variation in the proportion of milk energy from protein in captive Cercopithecine milks appears relatively constrained.
Supracluster Assembly of Archimedean Cages with 72 Hydrogen Bonds for the Aldol Addition Reaction
Authors: Liu Ya‐Jie , Su Hai‐Feng , Sun Yi‐Fan , Wang San‐Tai , Zhang Cheng‐Yang , Fang Wei‐Hui , Zhang Jian 
Published: October 2023

AbstractClusters that can be experimentally precisely characterized and theoretically accurately calculated are essential to understanding the relationship between material structure and function. Here, we propose the concept of “supraclusters”, which aim to connect “supramolecules” and “suprananoparticles” as well as reveal the unique assembly behavior of “supraclusters” with nanoparticle size at the molecular level. The implementation of supraclusters is full of challenges due to the difficulty in satisfying the ordered connectivity of clusters due to their abundant and dispersed hydrogen bonding sites. By solvothermal synthesis under a high catechol (H2CATs) content, we successfully isolated a series of triangular {Al6M3} cluster compounds possessing brucite‐like structural features. Interestingly, eight {Al6M3} clusters form 72‐fold strong hydrogen bonding truncatedhexahedron Archimedean {Al6M3}8 supracluster cage (abbreviated as H‐tcu). Surprisingly, the solution stability of the H‐tcu was further proved by electrospray ionization mass spectrometry (ESI‐MS) characterization. Therefore, it is not difficult to explain the reason for assembly of H‐tcu into edge‐directed and vertex‐directed isomers. These porous supraclusters can be obtained by scale‐up synthesis and exhibit a noticeable catalysis effect towards the condensation of acetone and p‐nitrobenzaldehyde. As an intermediate state of supramolecule and suprananoparticle, the supracluster assembly can enrich the cluster chemistry and bring new structural types.