bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Glutathione Peroxidase‐Mimicking Nanozyme Precisely Alleviates Reactive Oxygen Species and Promotes Periodontal Bone Regeneration
Authors: Zhu Bijun , Wu Jiangjiexing , Li Tong , Liu Songtao , Guo Junheng , Yu Yijun , Qiu Xinyi , Zhao Yue , Peng Haoran , Zhang Jinli , Miao Leiying , Wei Hui 
Published: October 2023

AbstractThe use of oxidoreductase nanozymes to regulate reactive oxygen species (ROS) has gradually emerged in periodontology treatments. However, current nanozymes for treating periodontitis eliminate ROS extensively and non‐specifically, ignoring the physiological functions of ROS under normal conditions, which may result in uncontrolled side effects. Herein, using the MIL‐47(V)‐F (MVF) nanozyme, which mimics the function of glutathione peroxidase (GPx), it is proposed that ROS can be properly regulated by specifically eliminating H2O2, the most prominent ROS. Through H2O2 elimination, MVF contributes to limiting inflammation, regulating immune microenvironment, and promoting periodontal regeneration. Moreover, MVF stimulates osteogenic differentiation of periodontal stem cells directly, further promoting regeneration due to the vanadium in MVF. Mechanistically, MVF regulates ROS by activating the nuclear factor erythroid 2‐related factor 2/heme oxygenase 1 (Nrf2/HO‐1) pathway and promotes osteogenic differentiation directly through the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt) pathway. A promising periodontitis therapy strategy is presented using GPx‐mimicking nanozymes through their triple effects of antioxidation, immunomodulation, and bone remodeling regulation, making nanozymes an excellent tool for developing precision medicine.
Labile Coordination Interphase for Regulating Lean Ion Dynamics in Reversible Zn Batteries
Authors: Wang Chenxiang , Zhu Jason Zi Jie , Vi‐Tang Samantha , Peng Bosi , Ni Chenhao , Li Qizhou , Chang Xueying , Huang Ailun , Yang Zhiyin , Savage Ethan J. , Uemura Sophia , Katsuyama Yuto , El‐Kady Maher F. , Kaner Richard B. 
Published: October 2023

AbstractRechargeability in zinc (Zn) batteries is limited by anode irreversibility. The practical lean electrolytes exacerbate the issue, compromising the cost benefits of zinc batteries for large‐scale energy storage. In this study, a zinc‐coordinated interphase is developed to avoid chemical corrosion and stabilize zinc anodes. The interphase promotes Zn2+ ions to selectively bind with histidine and carboxylate ligands, creating a coordination environment with high affinity and fast diffusion due to thermodynamic stability and kinetic lability. Experiments and simulations indicate that interphase regulates dendrite‐free electrodeposition and reduces side reactions. Implementing such labile coordination interphase results in increased cycling at 20 mA cm−2 and high reversibility of dendrite‐free zinc plating/stripping for over 200 hours. A Zn||LiMn2O4 cell with 74.7 mWh g−1 energy density and 99.7% Coulombic efficiency after 500 cycles realized enhanced reversibility using the labile coordination interphase. A lean‐electrolyte full cell using only 10 µL mAh−1 electrolyte is also demonstrated with an elongated lifespan of 100 cycles, five times longer than bare Zn anodes. The cell offers a higher energy density than most existing aqueous batteries. This study presents a proof‐of‐concept design for low‐electrolyte, high‐energy‐density batteries by modulating coordination interphases on Zn anodes.
Sugar‐Derived Nanocrystalline Graphite Matrix C/C Composites with Excellent Ablative Resistance at 3000 °C
Authors: Zhang Wenzheng , Tan Mingyi , Chen Daming , Sun Boqian , Cheng Yuan , Xun Liancai , Hu Jingsheng , Hou Chenlin , Liu Yuxuan , Fang Yuhao , Hu Ping , Han Wenbo , Dong Shun , Du Shanyi , Han Jiecai , Miao Shuxi , Yang Qidong , Zhou Yanchun , Zhang Xinghong 
Published: October 2023

AbstractSugars are renewable resources essential to human life, but they are rarely used as raw materials for the industrial production of carbon‐based materials, especially for the preparation of carbon fiber‐reinforced carbon‐matrix (C/C) composites, which are extremely useful for the semiconductor and aerospace sectors. Herein, a method utilizing sugar‐derived carbon to replace petrochemicals as dense matrix to preparing C/C composites is reported. The matrix from sugar‐derived C/C (S–C/C) composites has a nanocrystalline graphite structure that is highly thermally stable and effectively bonded to the carbon fibers. The mechanical properties of the S–C/C composite are comparable to those prepared from petrochemical sources; significantly, it exhibits a linear ablation rate of 0.03 mm s−1 after 200 s of ablation at 3000 °C in 10 MW m−2 heat flux. This new class of S–C/C is promising for use in a broad range of fields, ranging from semiconductor to aerospace.
Base‐Promoted Synthesis of N−H Free Pyrroles via net [3+2]‐Cycloaddition
Authors: Jin Huimin , Zhou Fan , Xiang Zhenhua , Chen Lingfeng , Liang Guang , Walsh Patrick J. , Li Jie 
Published: October 2023

AbstractA base‐promoted net‐[3+2] cycloaddition of nitriles and 1‐arylpropynes for the synthesis of pyrroles is described. The developed method provides convenient access to various 2,5‐disubstituted or 2,4,5‐trisubstituted pyrroles in 40% to 96% yields (32 examples). Among methods for the synthesis of pyrroles, the protocol presented here stands out for its convenience and atom‐economy.
Mitigating Intrinsic Interfacial Degradation in Semi‐Transparent Perovskite Solar Cells for High Efficiency and Long‐Term Stability
Authors: Naqvi Syed Dildar Haider , Son Kyungnan , Jung Wonzee , Hwang Hui ung , Lee Sangmin , Lee Arheum , Keum Minjong , Kim Sunwook , Kim Jeong Won , Kang Min Gu , Song Hee‐eun , Hong Sungjun , Jeong Inyoung , Ahn Seungkyu , Lambertz Andreas , Ding Kaining , Duan Weiyuan , Yim Kanghoon , Ahn SeJin 
Published: October 2023

AbstractConventional semi‐transparent perovskite solar cells (ST‐PSCs) generally exhibit inferior performance and stability relative to opaque PSCs. However, a comprehensive understanding of the origins of inferior performance and stability of ST‐PSCs and a practical solution to these challenges are both lacking. Here, it is shown for the first time that lithium ions from a lithium bis(trifluoromethanesulfonyl)imide (LiTFSI)‐doped 2,2′,7,7′‐tetrakis[N,N‐di(4‐methoxyphenyl)amino]−9,9′‐spirobifluorene (Spiro‐MeOTAD) hole‐transport layer (HTL) can diffuse into the molybdenum trioxide buffer layer at their interface, yielding ST‐PSCs with lower efficiency and accelerated degradation. It is also demonstrated that this undesired Li‐ion diffusion can be avoided by HTL surface modification with stable lithium oxides. Using this approach, the constructed ST‐PSC exhibits a new record power conversion efficiency (PCE) of 22.02% (21.68% certified) and a fill factor of >80%, with >99% shelf‐stability after 400 h and >99% operational stability for 240 h, which clears away this longstanding limitation of the performance and stability of ST‐PSCs. This strategy is also applied to fabricate four‐ and two‐terminal perovskite/silicon tandem solar cells with bifacial equivalent efficiencies of 31.5% and 26.34%, respectively, at 20% albedo.
Optimizing Fe‐3d Electron Delocalization by Asymmetric Fe–Cu Diatomic Configurations for Efficient Anion Exchange Membrane Fuel Cells
Authors: Liu Yarong , Yuan Shuai , Sun Caiting , Wang Changli , Liu Xiangjian , Lv Zunhang , Liu Rui , Meng Yazi , Yang Wenxiu , Feng Xiao , Wang Bo 
Published: October 2023

AbstractPrecisely designing asymmetric diatomic configurations and studying their electronic regulation effect for improving the oxygen reduction reaction (ORR) performance are important for anion exchange membrane fuel cells (AEMFCs). Here, a Fe, Cu co‐doped 2D crystalline IISERP‐MOF27 nanosheet derived FeN3O‐CuN4 diatomic site nanocatalyst (named as FeCu‐NC) is synthesized for the cathodes of AEMFCs. Thanks to the optimal electronic structure of FeN3O‐CuN4 in the FeCu‐NC catalyst, it shows enhanced half‐wave potential (0.910 V), turnover frequency (0.165e s−1 site−1), and decreased activation energy (19.96 kJ mol−1) in KOH. The FeCu‐NC‐based AEMFC achieves extremely high kinetic current (0.138 A cm−2 at 0.9 V) and rated power density (1.09 W cm−2), surpassing the best‐reported transition metal‐based cathodes. Density functional theory calculations further demonstrate that the Cu‐N4 can break the localization of Fe‐3d orbitals, accelerate the electron transport, and optimize the OH adsorption, thus facilitating the ORR process.
Highly Efficient Photo Rechargeable Supercapacitor based on Ambipolar Interface of Graphitic Carbon Nitride and MXene
Authors: Kumar Sumana , Mondal Anindita , Panwar Vinod , Shekhawat Roopali , Misra Abha 
Published: October 2023

AbstractDual‐functional materials for both the optically and the electrochemically active electrode enable efficient direct storage of solar energy into electrical energy. A photo rechargeable supercapacitor is developed using an ambipolar interface of MXene (Ti3C2TX) and protonated graphitic carbon nitride under light illumination. An extraordinarily large increase of 1960 % in the electrochemical capacitance is measured under the light illumination (420 nm) compared to its dark capacitance. Ambipolar interface induces an anomalous increase in the capacitance at an ultra‐high scan rate of 1.5×105 mV/s under the light illumination. Moreover, the photo‐assisted, voltage of ~270 mV is generated in the rechargeable supercapacitor. The extraordinary results are attributed to the attractive interface of oppositely charged MXene and protonated graphitic carbon nitride.
Impact of Nano‐sized Inorganic Fillers on PEO‐based Electrolytes for Potassium Batteries
Authors: Khudyshkina Anna D. , Rauska Ulf‐Christian , Butzelaar Andreas J. , Hoffmann Maxi , Wilhelm Manfred , Theato Patrick , Jeschull Fabian 
Published: October 2023

AbstractThe low melting points of solid polymer electrolytes (SPEs) based on the KTFSI electrolyte salt allow comparatively low operation temperatures (below 50 °C) for K‐ion batteries, unlike their Li or Na counterparts. Unfortunately, for this reason the electrolyte is also rendered mechanically unsuitable in its function to act as a cell separator. Therefore, in this work the use of inorganic nanofillers (Al2O3 and SiO2) is explored with the aim to improve rheological, thermal and cation transport properties of the resulting polymer composite electrolytes. Their electrochemical properties were further examined in K‐metal symmetrical cells and K‐metal/SPE/K2Fe[Fe(CN)6] cells and compared to corresponding liquid electrolyte systems. As a result of particle‐polymer interactions, filler‐containing SPEs showed higher degrees of crystallinity combined with filler polymer interaction and thus improved mechanical integrity in the relevant temperature range of 25–55 °C, while maintaining similar ionic conductivities than a filler‐free sample above the melting temperature. Although plating‐stripping experiments in symmetrical cell setups suggested high cell resistances for various compositions and in some cases even rapid cell failure, Al2O3‐based SPEs generally displayed high capacity retention when cycled against a positive electrode (here Prussian blue analogue K2Fe[Fe(CN)6]) over 100–160 cycles and possibly beyond.
An Electron/Ion Dual Conductive Integrated Cathode Using Cationic/Anionic Redox for High‐Energy‐Density All‐Solid‐State Lithium‐Sulfur Batteries
Authors: Pan Wenli , Yamamoto Kentaro , Matsunaga Toshiyuki , Watanabe Toshiki , Kumar Mukesh , Thakur Neha , Uchiyama Tomoki , Uesugi Masayuki , Takeuchi Akihisa , Sakuda Atsushi , Hayashi Akitoshi , Tatsumisago Masahiro , Uchimoto Yoshiharu 
Published: October 2023

AbstractAll‐solid‐state lithium‐sulfur batteries (ASSLSB), composed of sulfur cathode and lithium metal anode with high theoretical capacity, have a potentially higher energy density by weight than a typical lithium‐ion battery (LIB). However, due to insulating sulfur, a relatively large proportion of electronic (carbon) and ionic (solid electrolyte) conductors are mixed for cathode fabrication, leading to inferior practical capacity. Herein, we report a novel integrated cathode Li2S‐LiI‐MoS2 which has relatively high electronic and ionic conductivities (the order of 10−4 S cm−1) without any carbon and solid electrolyte. The ASSLSB with integrated Li2S‐LiI‐MoS2 cathode delivers a remarkably high energy density of 1020 Wh kg−1 at the cathode level at room temperature. By applying precise X‐ray diffraction, pair distribution function analysis and X‐ray computed tomography, it is found that the formation of an ionic conducting phase composed mainly of LiI during discharge is responsible for the high rate capability. Furthermore, X‐ray absorption fine structure (XAFS) has also revealed the charge compensation mechanism and ascertained the involvement of both Mo 3d and S 3p orbitals during the charging and discharging process. It is believed the strategy will pave the way for developing high practical energy density at room temperature for all‐solid‐state batteries.
New risk stratification for adjuvant nivolumab for high‐risk muscle‐invasive urothelial carcinoma
Authors: Saito Takafumi , Kanao Kent , Matsumoto Kazuhiro , Fukumoto Keishiro , Igarashi Daisuke , Takahashi Takayuki , Kaneko Go , Shirotake Suguru , Nishimoto Koshiro , Mizuno Ryuichi , Ishida Masaru , Hara Satoshi , Oya Mototsugu , Oyama Masafumi 
Published: October 2023

AbstractObjectivesWe aim to evaluate the risk of recurrence after neoadjuvant chemotherapy followed by radical cystectomy, particularly in ypT2 disease in patients with urothelial carcinoma, because it is not clear if all eligible patients with high‐risk muscle‐invasive urothelial carcinoma should be treated with adjuvant nivolumab.Materials and MethodsWe analysed the radiological and clinicopathological features, including cT and ypT stages, of 197 patients who had undergone two to four cycles of cisplatin‐based neoadjuvant chemotherapy and radical cystectomy without adjuvant chemotherapy. We stratified the risk of postoperative recurrence by these factors.ResultsThe median observation period was 29.6 (interquartile range, 11.4–71.7) months, and disease recurrence was observed in 58 patients. Multivariate analysis revealed that ypT stage (P = 0.019) and lymphovascular invasion (P = 0.015) were independent risk factors for postoperative recurrence. The ypT2 group (n = 38) had significantly better recurrence‐free survival than the ypT3 group (n = 41) (median recurrence‐free survival: not reached vs. 13.4 months, respectively, P = 0.005). In ypT2 disease, the cT2 and ypT2 group (n = 15), which was diagnosed as cT2 preoperatively and then diagnosed as ypT2 postoperatively, had significantly better recurrence‐free survival than the cT3/4 and ypT2 group (n = 23) (median recurrence‐free survival: not reached vs. 63.1 months, respectively, P = 0.034). There was no significant difference in recurrence‐free survival between the ypT ≤ 1 (n = 106) and the cT2 and ypT2 groups (median recurrence‐free survival: not reached in both, P = 0.962).ConclusionPatients with cT2 and ypT2 stage have a relatively low risk of recurrence and thus have a lower need for adjuvant nivolumab, particularly those with ypT2.
Exploring nutrient supplementation and bioprocess optimization to improve the production of lentiviral vectors in serum‐free medium suspension cultures
Authors: Vaz Tiago A. , Rodrigues Ana F. , Coroadinha Ana S. 
Published: October 2023

AbstractThe use of lentiviral vectors (LV) in gene therapy has been growing in recent years. To meet the increasing clinical demand, LV production platforms will benefit from improved productivity and scalability to enable cost‐effective manufacture of LV‐based therapies. Here we report the adaptation of 293T cells to serum‐free suspension cultures and the improvement of LV yields through transfection parameters optimization, process intensification and medium supplementation with nutrient boosters. Cells were sequentially adapted to different serum‐free culture media, transfection parameters were optimized and the two best‐performing conditions were selected to explore process intensification by increasing cell density at the time of transfection. LV production at higher cell densities increased volumetric titers up to 12‐fold and lipid supplementation was the most efficient metabolic optimization strategy further enhancing LV productivity by 3‐fold. Furthermore, cell concentration was identified and validated as an important source of transfection variability impairing cellular uptake of DNA polyplexes, impacting transfection efficiency and reducing LV titers down to 6‐fold. This work contributes to improving LV‐based gene therapy by establishing new scalable manufacturing platforms and providing key metabolic insights, unveiling important bioreaction parameters to improve vector yields.
Computational assessment of lipid production in Rhodosporidium toruloides in two‐stage and one‐stage batch bioprocesses
Authors: Castañeda María Teresita , Nuñez Sebastián , Jamilis Martín , De Battista Hernán 
Published: October 2023

AbstractOleaginous yeasts are promising platforms for microbial lipids production as a renewable and sustainable alternative to vegetable oils in biodiesel production. In this paper, a thorough in silico assessment of lipid production in batch cultivation by Rhodosporidium toruloides was developed. By means of dynamic flux balance analysis, the traditional two‐stage bioprocess (TSB) performed by the native strain was contrasted with one‐stage bioprocess (OSB) using four designed strains obtained by gene knockout strategies. Lipid titer, yield, content, and productivity were analyzed at different initial C/N ratios as relevant performance indicators used in bioprocesses. By weighting these indicators, a global lipid efficiency metric (GLEM) was defined to consider different scenarios. Under simulated conditions, designed strains for lipid overproduction in OSB outperformed the TSB in terms of lipid title (up to threefold), lipid yield (up to 2.4‐fold), lipid content (up to 2.8‐fold, with a maximum of 76%), and productivity (up to 1.3‐fold), depending on C/N ratios. Using these efficiency parameters and the proposed GLEM, the process of selecting the most suitable candidates for lipid production could be carried out before experimental assays. This methodology holds the potential to be extended to other oleaginous microorganisms and diverse strain design techniques.
Elucidating the effects of microbubble pinch‐off dynamics on mammalian cell viability
Authors: McRae Oliver , Walls Peter L. L. , Natarajan Venkatesh , Antoniou Chris , Bird James C. 
Published: October 2023

AbstractIn the biotechnology industry, ensuring the health and viability of mammalian cells, especially Chinese Hamster Ovary (CHO) cells, plays a significant role in the successful production of therapeutic agents. These cells are typically cultivated in aerated bioreactors, where they encounter fluid stressors from rapidly deforming bubbles. These stressors can disrupt essential biological processes and potentially lead to cell death. However, the impact of these transient, elevated stressors on cell viability remains elusive. In this study, we first employ /cgqamicrofluidics to expose CHO cells near to bubbles undergoing pinch‐off, subsequently collecting and assaying the cells to quantify the reduction in viability. Observing a significant impact, we set out to understand this phenomenon. We leverage computational fluid dynamics and numerical particle tracking to map the stressor field history surrounding a rapidly deforming bubble. Separately, we expose CHO cells to a known stressor level in a flow constriction device, collecting and assaying the cells to quantify the reduction in viability. By integrating the numerical data and results from the flow constriction device experiments, we develop a predictive model for cell viability reduction. We validate this model by comparing its predictions to the earlier microfluidic results, observing good agreement. Our findings provide critical insights into the relationship between bubble‐induced fluid stressors and mammalian cell viability, with implications for bioreactor design and cell culture protocol optimization in the biotechnology sector.
Neuropsychiatric complications and associated management in adolescent and young adult cancer survivors: An All of Us study
Authors: Agapito Ivann , Ng Ding Quan , Milam Joel , Ziogas Argyrios , Anton‐Culver Hoda , Chan Alexandre 
Published: October 2023

AbstractBackgroundAbout 4.5% of new cancer cases affect adolescent and young adult aged between 15 and 39 years in the United States (US). However, the effect of neuropsychiatric conditions on long‐term adolescent and young adult cancer (AYAC) survivors has not been formally investigated. Thus, the impact and management of late neuropsychiatric complications in AYAC survivors compared to non‐cancer‐matched controls (NCMC) in the US were evaluated using the All of Us (AoU) Research Program.MethodsParticipants in the AoU Controlled Tier Dataset (v6) diagnosed with cancer between ages 15 and 39 were identified from electronic health records and surveys. AYAC survivors were matched with NCMC using the optimal pair‐matching algorithm at a 1:4 ratio. Data on past diagnoses, current follow‐up care, and treatment patterns of neuropsychiatric complications were collected.ResultsAnalysis was performed on 788 AYAC survivors and 3152 NCMC. AYAC survivors, with an average of 8.8 years since their first cancer diagnosis, were more likely than NCMC to receive a diagnosis of neuropathy, memory loss and epilepsy (p  < 0.001). Survivors also had a higher rate of follow‐up care and treatment utilization for these neurological conditions compared to NCMC (p  < 0.05). Treatment utilization was highest among survivors receiving care for epilepsy (88%), and lower for neuropathy (70%), memory loss (61%), and chronic fatigue (59%).ConclusionsThis large study reveals that AYAC survivors, on average 9 years after their cancer diagnosis, require more frequent follow‐up care for neurological complications compared to non‐cancer individuals. However, the management of neuropathy, memory loss, and chronic fatigue is hindered by a lack of mechanism‐based effective therapies.