bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PR03: Hypoxia promotes inflammatory fibroblast formation in pancreatic cancer
Authors: Mello Ashley M. , Ngodup Tenzin , Lee Yusoo , Donahue Katelyn L. , Li Jinju , Rao Arvind , Carpenter Eileen S. , Crawford Howard C. , Magliano Marina Pasca Di , Lee Kyoung Eun 
Published: December 2023

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great promise against multiple deadly cancers, it has been largely ineffective in PDAC. This lack of response is in part attributed to its extensive, fibroinflammatory stroma and hypoxic microenvironment. Cancer-associated fibroblasts (CAFs) are a predominant and heterogeneous stromal cell type in PDAC, and single-cell transcriptomics of human and mouse PDAC has recently revealed a distinct CAF subpopulation, inflammatory CAFs (iCAFs). These inflammatory fibroblasts produce high levels of cytokines and chemokines in PDAC and have the potential to contribute to its immunosuppressive microenvironment and tumorigenesis. By injecting a hypoxia probe into PDAC mouse models, we recently found that iCAFs predominantly reside in hypoxic tumor regions. We also observed that the hypoxia-related gene signature is positively enriched in iCAFs in human PDAC samples. Importantly, by exposing three-dimensional (3D) co-cultures of pancreatic cancer cells and fibroblasts to either hypoxia or normoxia, we showed that hypoxia induces IL1α from cancer cells and that IL1α is required for hypoxia-mediated iCAF formation. Our data implicate hypoxia as a critical regulator of tumor stroma. Efforts are ongoing to understand the role of hypoxia in the crosstalk between cancer cells, fibroblasts, and immune cells in driving an immunosuppressive tumor microenvironment.
Citation Format: Ashley M. Mello, Tenzin Ngodup, Yusoo Lee, Katelyn L. Donahue, Jinju Li, Arvind Rao, Eileen S. Carpenter, Howard C. Crawford, Marina Pasca Di Magliano, Kyoung Eun Lee. Hypoxia promotes inflammatory fibroblast formation in pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2023 Oct 1-4; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Immunol Res 2023;11(12 Suppl):Abstract nr PR03.
Abstract PR05: Dgat1 camouflages sexual dimorphism in anti-tumor CD8+ T cell immunity
Authors: Madi Alaa , Cui Guoliang 
Published: December 2023

Abstract
The tumor microenvironment (TME) is enriched in various lipid species that are detrimental to anti-tumor T cell function. However, intratumoral CD8+ T cells were recently shown to require free fatty acids, which are also abundant in the TME, for survival and function. It is not clear whether these free fatty acids regulate transcription or serve as an energy source either directly or through a triacylglyerol (TAG) intermediate step (as in memory CD8+ T cells). Here, we generated mice with T cell-specific deletion of Dgat1, the enzyme that catalyzes the last and rate limiting step in TAG synthesis. We found that the function of Dgat1 in melanoma-infiltrating CD8+ T cells is sexually dimorphic. In female mice, loss of Dgat1 results in much smaller tumors whereas in male mice Dgat1 deficiency limits anti-tumor T cell function. Mechanistically, Dgat1 is required for the survival of stem-cell like Tim3-Slamf6+CD8+ T cells in male mice, but actively decreases their abundance in female mice in a CD8+ T cell-intrinsic manner. Using a number of mouse models we reveal that androgen receptor signaling induces the accumulation of lipid peroxides and the activation of the unfolded protein response in Dgat1-deficient CD8+ T cells. Our study provides insights into a previously unexplored metabolic adaptation of tumor-infiltrating T cells to sex hormones.
Citation Format: Alaa Madi, Guoliang Cui. Dgat1 camouflages sexual dimorphism in anti-tumor CD8+ T cell immunity [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2023 Oct 1-4; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Immunol Res 2023;11(12 Suppl):Abstract nr PR05.
Soufisme et Chérifisme. La généalogie discutée d’une famille vénérée : les chorfa Baqqālī
Authors: Boudchar Mohamed Reda 
Published: December 2023

Abstract
The return of the chorfa, especially the Idrīsids, on the social and political scene in Morocco from the 14th century onwards, and the advantages and privileges they acquired thanks to their symbolic capital, led to a vast polemic on the authenticity of their prophetic descent, at a period that saw the emergence of many individuals and families claiming to be genealogically linked to the Prophet. This is why the Baqqālī family, of Idrīsid origin, suffered the rejection of their sharifian nasab, especially after having left the rural world for Tétouan, a city where other sharifian families had settled. The controversy grew between the intellectual elite and the people in charge of verification (ahl al-tawṯīq), and its echo touched historiography, since this sharifian family also represented Sufi sanctity, combining spiritual influence with elements of domination and social privilege.
Abū l-Hudà al-Ṣayyādī (1850-1909), the niqābat al-ašrāf, and Sufism between Sunnah and Šīʿah in Late Ottoman Iraq (Šarīfism in Modernity I)
Authors: Jordan David 
Published: December 2023

Abstract
During the late nineteenth and early twentieth century, the Ottoman state’s efforts to centralize the Syndicate of Prophetic Descendants (niqābat al-ašrāf) was paralleled by the massive growth of Prophetic descendants (sādah and ašrāf) and the mass conversion to the Šīʿah among the tribes in the Iraqi provinces. This contribution aims to shed new light on the role of Abū l-Hudà al-Ṣayyādī (1266/1850-1327/1909), the imperial naqīb al-ašrāf and paramount šayḫ and architect of the Sunnī Rifāʿiyyah Sufi order, in this context. Analyzing a selection of Ṣayyādī’s publications on genealogies, Sufi doctrine, and poem collections, the article focuses on his contribution to the emergence of a special subgroup of Prophetic descendants in the Arab tribal landscape, namely al-sādah al-rifāʿiyyah, and on the significance of his genealogical constructions for his understanding of Sunnī Islam as distinct from Šīʿism.
Quête des ansāb et quête des ašrāf dans le monde arabe (XVe-XXe siècle)
Authors: Mayeur-Jaouen Catherine 
Published: December 2023

Abstract
One hundred years after Lévi-Provençal’s Les Historiens des Chorfa and almost twenty-five years after Oriente Moderno’s founding issue on sādāt and ašrāf, a new special issue of Oriente Moderno is devoted to the “quest for ansāb”, along with the quest for ašrāf. Our project focuses mainly on Morocco, and on modern and contemporary sources. Firstly, we will take stock of twentieth- and twenty-first-century historiography, with works devoted to Arab genealogy (Zoltàn Szombathy) and “sayyido-sharifology” (Kazuo Morimoto), and to the intersection of the two (Sara Bowen Savant and Helena de Felipe). Modern and contemporary history is still relatively neglected in a field of research favored by medievalists and ethnologists. Our project aims to reflect on the links between genealogical science, the writing of history and the question of ašrāf, at a time of religious politics. imperial politics and the construction of modern states. Focusing on Morocco, this issue adopts a comparative spirit with three studies on Iraq, genealogical literature in Ottoman Egypt and contemporary Mauritania.
The Role of Gassendi’s Dutch Correspondents in his Astronomical Work
Authors: Pantin Isabelle 
Published: December 2023

Abstract
Gassendi was much engaged in observational astronomy and in the effort to circulate astronomical knowledge. He corresponded with astronomers living in several European countries. The exchanges he had with Dutch correspondents, notably Martin Hortensius and Govaart Wendelen, were among the most fruitful. These exchanges, which followed the rules of the Republic of Letters, circulated information in support of long-term projects, such as the revision of geographical coordinates and cosmic dimensions, at the moment when the use of the telescope in combination with traditional measuring instruments established a higher standard of accuracy.
An Analysis of the Effects of Clouds in High-Resolution Forecasting of Surface Shortwave Radiation in South Africa
Authors: Mendes Joana , Zwane Nosipho , Mabasa Brighton , Tazvinga Henerica , Walter Karen , Morcrette Cyril J. , Botai Joel 
Published: December 2023

Abstract
We assess site-specific surface shortwave radiation forecasts from two high-resolution configurations of the South African Weather Service numerical weather prediction model, at 4 and 1.5 km. The models exhibit good skill overall in forecasting surface shortwave radiation, with zero median error for all radiation components. This information is relevant to support a growing renewable energy sector in South Africa, particularly for photovoltaics. Further model performance analysis has shown an imbalance between cloud and solar radiation forecasting errors. In addition, cloud overprediction does not necessarily equate to underestimating solar radiation. Overcast cloud regimes are predicted too often with an associated positive mean radiation bias, whereas the relative abundance of partly cloudy regimes is underpredicted by the models with mixed radiation biases. Challenges highlighted by the misrepresentation of partly cloudy regimes in solar radiation error attribution may be used to inform improvements to the numerical core, namely, the cloud and radiation schemes.

Significance Statement
This paper provides the first comprehensive assessment of high-resolution site-specific NWP forecasts of surface shortwave radiation in South Africa, exploring clouds as the main drivers of prediction biases. Error attribution analyses of this kind are close to none for this part of the world. Our study contributes to understanding how cloud and radiation schemes perform over South Africa, representing a step forward in the state of the art. In addition to the scientific interest, the capabilities developed through this work may benefit the second largest economy of the continent. In a country where energy security is of critical relevance, the availability of useful and usable weather information is paramount to support its industry and socioeconomic growth.
Anesthesia via peripheral nerve blocks during total knee replacement has no effect on postoperative inflammation in elderly patients
Authors: Lu Bin , Jin Jianwen , Pei Shujun , Gong Maowei , Liu Junle 
Published: December 2023

Background We have previously shown that, compared with general anesthesia (GA), the procedure of peripheral nerve blocks (PNB) facilitates faster recovery of elderly patients from total knee replacement (TKR). Here, we investigated whether the faster recovery is associated with decreased perioperative stress and inflammation and decreased incidences of postoperative complications. Methods After randomization, 165 patients aged ≥65 years underwent TKR under GA or PNB. The primary outcomes were the perioperative inflammation and stress levels, based on the serum C-reactive protein and interleukin-6 levels, erythrocyte sedimentation rate, white-blood cell and neutrophil counts, and blood-sugar level. The secondary outcomes were the postoperative complications, including cardiovascular, respiratory, and hepatic or renal complications, insomnia, delirium, electrolyte disturbances, and nausea and vomiting. Results The two groups were not significantly demographically different ( p > .05). Of the cytokines related to stress and inflammation, the differences of time points were statistically significant between the two groups ( p < .01), but two-way ANOVA revealed no interaction between the time points and groups. Incidences of postoperative complications were far lower in PNB group than in GA group ( p = .006). Incidences of postoperative respiratory complications ( p = .005) and postoperative nausea and vomiting ( p = .040) were significantly lower in PNB group than in GA group. There were no significant differences in other complications between the two groups ( p > .05). Conclusions PNB does not alleviate the stress and inflammation in elderly patients post TKR but significantly reduces the incidences of postoperative complications, especially respiratory complications, and nausea and vomiting. (ClinicalTrials.gov Identifier: NCT01871012)
Experiences of Fathers in Norway Attending an Online Course on Therapeutic Writing After the Death of a Child
Authors: Lehmann Olga V. , Kalstad Trine Giving , Neimeyer Robert A. 
Published: December 2023

After the unexpected death of a child, bereaved parents require prompt access to helpful support systems. Online therapeutic writing courses can make such support accessible. Because few studies have included bereaved fathers as participants, we explored the experiences of fathers whose children died unexpectedly and who were part of an online course of therapeutic writing in Norway. We piloted two courses (group 1, six weeks, n = 9; group 2, 5 weeks, n = 5). We describe our methodological considerations for using poetic representations in qualitative health research and present four poetic representations based on fieldwork notes written by the principal investigator. Then, we triangulate and narratively analyze them together with two collective poems written by participants from each group; excerpts of the writings from two fathers, one per group; evaluation surveys ( n = 4; n = 3); and, anonymous check-out journaling from the second group ( n = 3). Resistance was a salient feature of our participants’ grief, and writing enabled them to both be in contact with their emotional world and process difficult emotions as they looked for meaning despite the death of their children. Those who attended the most classes perceived the course as transformative, being part of an ongoing self-exploration, and a possibility to continue and strengthen the bond with their children. Our findings mirror the complexities of the grief experiences of fathers, giving account of their need to find a rhythm to dive into their emotional world, the importance of peer support, and the value of diversifying intervention techniques to meet individual needs and preferences.
Optimization design and analysis of the broadband acoustic absorber of the microperforated panel with an interpolated straight tube
Authors: Li Qi , Wu Jinwu , Mao Qibo , Jv Xin , Chen Minghao 
Published: December 2023

The microperforated panel (MPP) structure is widely used in the field of noise reduction. The traditional MPP structure has a fixed absorption peak, and the optimized MPP structure has an improved absorption band, but the frequency range of the absorption is not ideal. For the design of broadband absorption in MPP structures, this paper presents a MPP acoustic absorber structure (N-MH) with an interpolated straight tube (IST) designed for superior broadband acoustic performance. The N-MH structure combines the advantages of the MPP and the embedded necked Helmholtz resonator, as well as having a sub-wavelength thickness of only 60 mm, which is only 1/14th of the wavelength at the first resonant frequency. The N-MH structure is optimized based on the particle swarm optimization (PSO) algorithm. In comparison to traditional microperforated panel structures, the N-MH structure exhibits a significantly broader sound absorption frequency band. Additionally, we thoroughly investigate the factors influencing the mid-low-frequency sound absorption performance of the N-MH structure. Through theoretical prediction, simulation analysis, and experimental testing, it is verified that the N-MH structure has excellent broadband sound absorption characteristics in the frequency interval of 0–2000 Hz, and the percentage of sound absorption bands with absorption coefficients exceeding 0.9 can reach 78.2%.
Barriers and facilitators that hospital clinicians perceive to discuss the personal values, wishes, and needs of patients in palliative care: a mixed-methods systematic review
Authors: de Vries Sita , Verhoef Mary-Joanne , Vervoort Sigrid Cornelia Johanna Maria , van der Linden Yvette Milene , Teunissen Saskia Cornelia Constantia Maria , de Graaf Everlien 
Published: December 2023

Background: The exploration and monitoring of the personal values, wishes, and needs (VWN) of patients in the palliative phase by hospital clinicians is essential for guiding appropriate palliative care. Objective: To explore the barriers and facilitators concerning communication with patients in the palliative phase about their VWN as perceived by hospital clinicians. Design: A mixed-methods systematic review following the Joanna Briggs Institute guidelines for mixed-method systematic reviews and Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines was conducted (PROSPERO ID: CRD42021216693). Data sources and methods: Eight databases, including PubMed, Embase, and CINAHL, were searched without time restrictions. The search string was built using the search Palliative cAre Literature rEview iTeraTive mEthod (PALETTE) framework. Eligible studies focused on (1) hospital clinicians and (2) perceived barriers and facilitators regarding the exploration and monitoring of the VWN of adult patients in the palliative phase. Two researchers independently selected articles and evaluated the quality. Findings were synthesized using a convergent integrated approach. Results: In total, 29 studies were included: 14 quantitative, 13 qualitative, and 2 mixed methods. Five synthesized findings were identified: (1) the clinician’s professional manners, (2) the image formed of the patient and loved ones, (3) the human aspect of being a clinician, (4) the multidisciplinary collaboration, and (5) the contextual preconditions. Most studies seemed focused on communication about treatment decision making. Conclusion: A patient-centered approach seems lacking when clinicians discuss the patient’s VWN, since most studies focused on treatment decision making rather than on the exploration and monitoring of the multidimensional well-being of patients. This review emphasizes the need for the development and integration of a systematic approach to explore and monitor the patients’ VWN to improve appropriate palliative care in hospitals.
Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone Induction and Consolidation with Tandem Transplant in High-Risk Newly Diagnosed Myeloma Patients: Final Results of the Phase 2 Study IFM 2018-04
Authors: Touzeau Cyrille , Perrot Aurore , Hulin Cyrille , Manier Salomon , Macro Margaret , Chretien Marie-Lorraine , Karlin Lionel , Decaux Olivier , Jacquet Caroline , Tiab Mourad , Leleu Xavier , Corre Jill , Jobert Alexandra , Planche Lucie , Avet-Loiseau Herve , Moreau Philippe 
Published: December 2023

Background: High-risk (HR) cytogenetic is associated with poor outcome in transplant eligible (TE) newly diagnosed multiple myeloma (NDMM). The triplet combination carfilzomib lenalidomide and dexamethasone (KRD) plus transplantation demonstrated high efficacy with favorable safety profile in TE-NDMM patients (FORTE). The addition of daratumumab (Dara) to frontline therapy also improved response rate and progression free-survival in TE-NDMM patients (CASSIOPEIA, GRIFFIN). Double transplant also improved outcome of HR TE NDMM patients (EMN02). The phase 2 trial 2018-04 from the Intergroupe Francophone du Myelome (IFM) evaluated an intensive strategy with Dara-KRD induction and consolidation plus double transplant in HR TE NDMM (NCT03606577).
Methods: HR MM was defined by the presence of del17p, t(4;14) and/or t(14;16). Treatment strategy included Dara-KRD induction (6 cycles), autologous stem cell transplantation (ASCT), Dara-KRD consolidation (4 cycles), second ASCT, Dara-lenalidomide maintenance for 2 years. The primary endpoint was the feasibility of this intensive strategy.
Results: Fifty patients with previously untreated NDMM were included from july 2019 to march 2021 in 11 IFM centers. Median age was 57 (range 38 -65). Based on inclusion criteria, all patients had HR cytogenetic, including 17p deletion (n=20, 40%), t(4;14) (n=26, 52%) or t(14;16) (n=10, 20%). Four (8%) patients had extramedullary disease. At data cut-off, the study met the primary endpoint with 36 (72%) patients completing second transplant. Twenty-one patients (42%) discontinued the study, due to stem-cell collection failure (n=8), disease progression (n=8), adverse event (n=4), consent withdrawal (n=1). Grade 3-4 Dara-KRD induction/consolidation related adverse event (&gt;5% of patients) were neutropenia (44%), anemia (22%), thrombocytopenia (24%) and infection (14%). Four patients discontinued treatment due to severe adverse event (COVID-19 infection, drug-induced hepatitis, JC virus related encephalopathy, intracerebral hemorrhage). Seven patients died, 5 due to disease progression and 2 due to infection. Responses deepened over time with an overall response rate before maintenance of 100%, including 81 % complete response. Among evaluable patients (33/36), pre maintenance Minimal Residual Disease negativity rate (NGS, 10 -6) was 94%. After a median follow up of 32 months, the 24-months PFS is 87% (78-87%) and the 24-months OS is 94% (87-100%).
Conclusions: Dara-KRD induction/consolidation with tandem transplant was feasible in TE NDMM patients with high-risk cytogenetic profile, and resulted in high MRD negativity rate and high progression free survival.