bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low sex hormone-binding globulin levels and reduced risk of chronic kidney disease in adults
Authors: Wang Lingling , Chen Jianlan , Li Changhao , Xin Xiaoqin 
Published: December 2023

Abstract
Investigation on the association between serum sex hormone-binding globulin (SHBG) and chronic kidney injury are few. However, the evidence supporting this finding is limited and controversial. The purpose of this study was to estimate the effects SHBG had on chronic kidney disease (CKD). A total of 8,742 adults from the National Health and Nutrition Examination Survey (NHANES) (2013–2016) were selected in the present study. CKD was viewed as estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m2 or urine albumin to creatinine ratio (UACR) ≥ 30 mg/g.A significant association between SHBG (log2 transform) and the prevalence of CKD was observed based on a full adjustment model (OR 1.04; 95% CI 1. 14- 1.49). For ensuring the robustness of the results, the analysis of subgroups stratified by gender and age, and the results were still stable in a series of sensitive analysis (p for trend < 0.05). Significant correlations were observed of serum SHBG with kidney impairment among both males and females. Causation and potential mechanisms should be further investigated in future prospective cohort studies and basic researches.
Description of the attitudes of the surgical team toward the implementation of robotic surgery in the Tunisian public health institution
Authors: Belgacem Amina , Sebri Ameni , Bekalti Wiem , Chouari Monia , Chrif Taieb , Soussi Sonia 
Published: December 2023

Abstract
Introduction The introduction of robotic surgery is a major advance for this decade. The implementation of this technology determines the future of this potential progress in Tunisian hospitals. The purpose of this study was to describe the attitudes towards the implementation of robotic surgery among the surgical team in the Tunisian public health institution. Materials and methods It was a quantitative descriptive study conducted in 2023 in the Tunisian public health institution. The study sample consisted of 46 professionals from the carcinology operating theatre. We used a valid and reliable questionnaire with satisfactory psychomotor characteristics. The original English version of the questionnaire was emailed to us by the corresponding author McBride KE with authorisation the measuring instrument. The interpretation of the results was based on the “Health Technology Acceptance Model”. Results More than half of our population had positive attitudes about the benefits of robotics in patient care: (78.3%) agreed that robotic surgery will improve the quality of surgical care and that after initial training robotic surgery will reduce operating time (76.1%). (97.8%) liked learning the new skills required to use the robot. Concerns were a little high. :(65.2%) of the respondents said that they were involved in the care and handling of the robot and its surgical equipment and that they had little opportunity to take part in the surgical programme. Our study identified key factors for the successful implementation of robotic surgery: communication (93.5%), responsibility (91.3%), and theoretical and practical training (87%). Conclusion Robotic surgery is a technology that is transforming the field of health, in the modernisation of health establishments.
Analytical study of the propagation of nonlinear waves on a Murnaghan hyperelastic circular pipe
Authors: Althobaiti Saad 
Published: December 2023

Abstract
The propagation of waves on nonlinear structures is a vital feature that plays a significant part in elastodynamics. Thus, the current study makes use of some powerful analytical approaches to examine the propagation of nonlinear elastic waves on a Murnaghan hyperelastic circular pipe. Indeed, the admittance of double dispersion terms coupled with the presence of material nonlinearity in the governing nonlinear mode is what makes the study superb. Therefore, some interesting exact analytical solutions are constructed and further analyzed with regard to the parameters that characterize the propagation. In the end, some graphical depictions of some of the gained solutions are supplied to for clarification.
A recurrence prognosis model of colorectal cancer based on preoperative nutritional score and clinical features
Authors: 东 哥哥 , Huang Mingliang , Xu Heyang , Zeng Yujie , Lan Qiusheng , Liu Lu , Chu Zhonghua , Lai Wei 
Published: December 2023

Abstract
Objective:
To analyze the relationship between preoperative NRS2002 score, COUNT score, and clinical tumor characteristics with postoperative recurrence in patients with stage I-III colorectal cancer. To establish a prediction model using Lasso-Cox regression and visualize the model using a nomogram.
Methods:
A retrospective study was conducted on 235 patients with stage I-III colorectal cancer who underwent radical resection at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, from January 2018 to July 2019. Lasso-Cox regression identified risk factors for tumor recurrence, and the results were used to establish a Cox proportional hazards regression model. The model was visualized using a nomogram. Bootstrap resampling was employed to internally validate the model.
Results:
The Cox model included BMI, preoperative intestinal obstruction, neural invasion, tumor differentiation, serum albumin, total lymphocyte count, and pN stage, which were selected using Lasso regression. The C-index for 1-year DFS was 0.8 (95% CI: 0.77–0.84), for 2-year DFS was 0.8 (95% CI: 0.78–0.83), and for 3-year DFS was 0.78 (95% CI: 0.75–0.80). The ROC curve of the model had an AUC of 0.82 (95% CI: 0.78–0.86) for 1-year DFS, 0.82 (95% CI: 0.80–0.85) for 2-year DFS, and 0.80 (95% CI: 0.76–0.83) for 3-year DFS, indicating good discriminative ability. Bootstrap resampling was used for model calibration, and the calibration curves for 1-year DFS, 2-year DFS, and 3-year DFS showed good fit with the standard curve, indicating good calibration of the model. Decision curve analysis (DCA) showed that the model had better clinical applicability compared to TNM staging. Finally, a nomogram was constructed to visualize the results.
Conclusion:
The nomogram prediction model, derived from Lasso-Cox regression, integrates preoperative nutritional and immune status, tumor pathological characteristics, and clinical symptoms. It demonstrates greater clinical utility than TNM staging in identifying high-risk patients for postoperative recurrence. The nomogram offers guidance for screening and developing personalized follow-up strategies or treatment plans for patients with predicted recurrence risk, aiming to enhance long-term prognosis.
Polyvascular Atherosclerosis and Renal Dysfunction Increase the Odds of Cognitive Impairment in Vascular Disease: Findings of the LipidCardio Study
Authors: König Maximilian , Palmer Katie , Steinhagen-Thiessen Elisabeth , Demuth Ilja 
Published: December 2023

Abstract
Introduction: Growing evidence suggests a causal role for atherosclerotic vascular disease in cognitive impairment and dementia. Atherosclerosis may present as monovascular disease (monoVD) or as widespread polyvascular atherosclerotic disease polyVD). Evidence on the relationship between monoVD or polyVD and cognitive impairment is limited.
Methods: We conducted a cross-sectional analysis of baseline data from the LipidCardio Study. The main outcome measure was the presence of cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score < 26.
Results: The mean age was 71.5 years, 30.3% were female, 17.3% had no evidence of large-vessel atherosclerosis, 71.1% had monoVD, and 11.7% had polyVD, defined as the presence of atherosclerosis in ≥2 vascular territories (coronary, cerebral, aortic, or lower extremity). A total of 21.6% had cognitive impairment according to the prespecified cutoff (MMSE < 26). Overall, the odds of cognitive impairment increased for each additional vascular territory affected by atherosclerosis (adjusted odds ratio 1.76, 95% confidence interval (CI) 1.21-2.57, p = 0.003). Furthermore, there is evidence for an interaction between vascular disease and chronic kidney disease (CKD). The odds of cognitive impairment were not greater in the monoVD subgroup than in the no atherosclerosis subgroup (OR 1.05, 95% CI 0.50-2.19; p = 0.906), while the odds ratio (OR) of cognitive impairment with polyVD compared to no atherosclerosis was 3.15 (95% CI 1.24-8.00; p = 0.015). In contrast, in patients with CKD, both monoVD and polyVD were associated with significantly greater odds of cognitive impairment than was no atherosclerosis.
Conclusions: PolyVD is associated with increased odds of cognitive impairment. MonoVD is associated with cognitive impairment only in the presence of CKD.
Synergistic effects of elevated temperature with pesticides on reproduction, development and survival of dung beetles
Authors: Esquivel-R Andrea , Baena-Díaz Fernanda , Bustos-Segura Carlos , De Gasperin Ornela , González-Tokman Daniel 
Published: December 2023

Abstract

In times of global change, high temperatures can potentiate the negative effects of pesticides and other stressors. Here, we evaluated under controlled laboratory conditions the effect of a moderate increase in temperature in combination with ivermectin (an antiparasitic drug used in cattle that is excreted in dung), an herbicide, and parasitic pressure, on the reproductive success, development time and adult survival of dung beetles Euoniticellus intermedius, which are naturally exposed to these stressors. We found that heat increased the number and proportion of emerged offspring, but in combination with ivermectin, herbicide and parasitic treatments, it had synergistic negative effects. Moreover, heat in combination with ivermectin and with parasitism caused a synergistic increase of adult offspring mortality and, in combination with the herbicide, heat synergistically accelerated development. Our results indicate that heat can enhance the negative effect of other stressors and act synergistically with them, harming dung beetles, a group with important ecological and economic value in natural and productive ecosystems. Although adult sex ratio was not affected by experimental treatments, contrasting responses were found between males and females, supporting the idea that both sexes use different physiological mechanisms to cope with the same environmental challenges. The effects that combined stressors have on insects deepen our understanding of why we are losing beneficial species and their functions in times of drastic environmental change.
Assessment of two steroid hormones Progestin and estrogen on cellular model Paramecium: oxidative stress, Mitochondrial swelling and kinetic.
Authors: Zouaoui Sara , Rouabhi Rachid , Bouzenzana Sara , Menaceur Fouad , Gasmi Salim , Benaicha Brahim 
Published: December 2023

Abstract
Synthetic steroids like progestin and estrogen, which are frequently present in contraceptive pills, alter behavior, physiology, and biochemistry in life beings. Although, the harmful effects of neosynthesized products are widely researched, there are no reports on their individual or mixture uses. Therefore, this study is to evaluate the effects of each component alone and in combination on Paramecia, a freshwater protozoan, at low relevant ambient concentrations in a ratio that is comparable to that of most recommended by doctors. The cells kinetics test was used to evaluate the acute toxicity of these two steroids, individually and their mixture after 24 and 48 hours. Furthermore, the consequences of oxidative stress were investigated over a duration of 120 hours. While the mixture largely impeded motility, immobility was concentration-dependent, Progestin is less impacts than Estrogen. Oxidative stress responses demonstrated a substantial drop in GSH contents and SOD, CAT activity, as well as an increase in MDA levels and GST activity in treated groups relative to the control (p < 0.01). These results imply that while these two steroids caused a generation of reactive oxygen species (ROS) in Paramecium, this result was confirmed by the mitochondrial assessments respiration and swelling that explain the amount of cellular number reduction.
A simple method for obtaining heat capacity coefficients of minerals
Authors: Bowman Samuel , Pathak Arkajyoti , Agrawal Vikas , Sharma Shikha 
Published: December 2023

Abstract
Heat capacity data are unavailable or incomplete for many minerals at geologically relevant temperatures. Despite the availability of entropy and enthalpy values in numerous thermodynamic tables (even sometimes at elevated temperatures), there remains need for extrapolation beyond, or interpolation between, temperatures. This approach inevitably results in estimates for entropy and enthalpy values because the heat capacity coefficients required for optimal thermodynamic treatment are less frequently available. Here we propose a simple method for obtaining heat capacity coefficients of minerals. This method requires only the empirically measured temperature-specific heat capacity for calculation via a matrix algorithm. The system of equations solver is written in the Python computing language and has been made accessible in an online repository. Thermodynamically, the solution to a system of equations represents the heat capacity coefficients that satisfy the mineral-specific polynomial. Direct coefficient calculation will result in more robust thermodynamic data, which are not subject to fitting uncertainties. Using hematite as an example, this method provides results that are comparable to conventional means and is applicable to any solid material. Coefficients vary within the traditional large 950 K temperature interval, indicating that best results should instead utilize a smaller 400 K temperature interval. Examples of large-scale implications include the refinement of geothermal gradient estimation in rapidly subsiding sedimentary basins or metamorphic and hydrothermal evolution.
PELATIHAN KULTUR JARINGAN TUMBUHAN BAGI SISWA SMA NEGERI 7 YOGYAKARTA
Authors: None Ratih Restiani , Ariestanti Catarina Aprilia , Purba Laurentia Henrieta Permita Sari , Retnowati Theresia Sri , Matheos Josiah Herald , Kaban Sarah Mega Pratenna , Sekar Astrid Ayu 
Published: December 2023

Kultur jaringan tumbuhan merupakan salah satu topik dalam modul Bioteknologi pada mata pelajaran Biologi kelas XII Sekolah Menengah Atas. Topik ini belum opimal diberikan di sekolah khusunya di SMA Negeri 7 Yogyakarta karena keterbatasan SDM yang berpengalaman di bidang kultur jaringan tumbuhan dan belum tersedianya fasilitas dan peralatan yang mendukung pelaksanaan praktikum topik tersebut. Oleh karena itu, kegiatan ini bertujuan untuk untuk membantu siswa dalam memperoleh pengetahuan dan keterampilan mengenai prinsip dasar, manfaat, dan tahapan kerja kultur jaringan tumbuhan. Selain itu kegiatan ini diharapkan dapat bermanfaat dalam membantu tercapainya kompetensi dasar pengetahuan dan keterampilan dalam modul Bioteknologi mata pelajaran Biologi Kelas XII. Pelatihan dilaksanakan di laboratorium Bologi SMA Negeri 7 Yogyakarta diikuti oleh 10 orang siswa kelas XII anggota kelompok Karya Ilmiah Remaja (KIR). Tahap pelatihan meliputi tanya jawab sebelum materi, pemaparan materi, pelaksanaan praktikum, tanya jawab setelah praktikum, dan evaluasi. Materi diberikan menggunakan metode ceramah dan diskusi interaktif, dilanjutkan kegiatan praktikum meliputi pembuatan media kultur, sterilisasi dan inokulasi eksplan serta aklimatisasi yang dilaksanakan melibatkan partisipasi aktif masing-masing siswa. Hasil yang diperoleh dalam pelatihan ini adalah siswa mampu memahami dan melaksanakan kegaitan praktikum kultur jaringan tumbuhan dengan baik.
Utilização de software para o monitoramento de internações em pronto-socorro: Estudo-piloto
Authors: Rocha Hertaline Menezes do Nascimento , Trindade Mônica Viviany Silveira , Nascimento Nicoly Gabrielly Brito , Santos Thaiane Santana , Jesus Aryel Andrade de , Farre Anny Giselly Milhome da Costa , De Santana Filho Valter Joviniano 
Published: December 2023

Objetivo: realizar o monitoramento das internações no pronto-socorro de um Hospital Universitário utilizando o Sistema de Informação e Monitoramento das Internações no Pronto-Socorro (Simips) que foi criado com o objetivo de monitorar as internações no PS e gerar informações que auxiliem na prática assistencial e na gestão de leitos, da qualidade da assistência e de riscos assistenciais. Método: trata-se de estudo-piloto que monitorou as internações de pacientes adultos em PS, da admissão em regime de internação até a saída, utilizando o Simips. A amostra foi composta por prontuários de pacientes adultos admitidos em regime de internação no PS durante os meses de junho a agosto de 2019. Foram coletados dados socioepidemiológicos, escore de gravidade, escore de dependência dos cuidados de enfermagem, escore News, ocorrência de eventos adversos, tempos de permanência e os desfechos de saída. Resultados: foram analisados 158 prontuários de pacientes com mediana de 65 anos de idade. No grau de dependência dos cuidados de enfermagem, 89% foram classificados como cuidados mínimos no primeiro dia de internação hospitalar. A frequência de eventos adversos foi 39,2% e o atraso na terapêutica (administração) medicamentosa (12%) e a ausência de conciliação medicamentosa (8,9%) foram os mais prevalentes. Conclusão: o estudo mostrou um tempo de permanência no alto de pacientes em regime de internação no PS, com predominância de pacientes idosos e uma alta incidência de eventos adversos.

desfecho, de forma clara, rápida e acessível, mostrou-se importante ao apontar situações que necessitam de intervenção imediata para melhorar a qualidade e segurança da assistência.
Manifestations and Outcomes of Intracerebral Hemorrhage During the COVID-19 Pandemic in China: Multicenter, Longitudinal Cohort Study
Authors: Wan Yan , He Quan Wei , Chen Shaoli , Li Man , Xia Yuanpeng , Zhang Lei , Sun Zhou , Chen Xiaolu , Wang David , Chang Jiang , Hu Bo 
Published: December 2023

Background
The COVID-19 pandemic has inevitably affected the distribution of medical resources, and epidemic lockdowns have had a significant impact on the nursing and treatment of patients with other acute diseases, including intracerebral hemorrhage (ICH).

Objective
This study aimed to investigate how the COVID-19 pandemic affected the manifestations and outcomes of patients with ICH.

Methods
Patients with acute ICH before (December 1, 2018-November 30, 2019) and during (December 1, 2019-November 30, 2020) the COVID-19 pandemic at 31 centers in China from the Chinese Cerebral Hemorrhage: Mechanism and Intervention (CHEERY) study were entered into the analysis. Demographic information and clinical manifestations and outcomes were collected and compared between the 2 groups.

Results
From December 1, 2018, to November 30, 2020, a total of 3460 patients with ICH from the CHEERY study were enrolled and eventually analyzed. The results showed that during the COVID-19 pandemic, patients with ICH were more likely to be older (P<.001) with a history of ischemic stroke (P=.04), shorter time from onset to admission (P<.001), higher blood pressure (P<.001), higher fasting blood glucose (P=.003), larger hematoma volume (P<.001), and more common deep ICH (P=.01) and intraventricular hemorrhage (P=.02). These patients required more intensive care unit treatment (P<.001) and preferred to go to the hospital directly rather than call an ambulance (P<.001). In addition, the COVID-19 pandemic was associated with an increased risk of pulmonary infection during hospitalization (adjusted risk ratio [RRadjusted] 1.267, 95% CI 1.065-1.509), lower probability of a 3-month good outcome (RRadjusted 0.975, 95% CI 0.956-0.995), and a higher probability of in-hospital (RRadjusted 3.103, 95% CI 2.156-4.465), 1-month (RRadjusted 1.064, 95% CI 1.042-1.087), and 3-month (RRadjusted 1.069, 95% CI 1.045-1.093) mortality.

Conclusions
Our study indicated that the cloud of COVID-19 has adversely impacted the presentation and outcomes of ICH. Medical workers may pay more attention to patients with ICH, while the public should pay more attention to hypertension control and ICH prevention.

Trial Registration
Chinese Clinical Trial Registry ChiCTR1900020872; https://www.chictr.org.cn/showprojEN.html?proj=33817
Editorial
Authors: Daset Lilian R. 
Published: December 2023

De la Pluma al Mousse
En esta edición que tiene como eje el formato digital hemos recurrido a la manida expresión “de la pluma al mousse” para referirnos al gran paso que deben dar las publicaciones científicas en estos tiempos. La digitalización sin duda ha supuesto cambios en nuestros comportamientos, ha creado nuevos hábitos o los ha transformado en alguna medida, además de producir modificaciones en aspectos más profundos y personales como son nuestras creencias y emociones. Al gestionar una publicación en ciencia esto implica que los equipos editoriales deben concebir toda la gestión desde otro esquema de pensamiento; el producto final debe poder visualizarse en formato web y no en el volumen y número de papel, con sus propias reglas y estándares. Algo simple, pero no tanto, un cambio de esquema importante.
Se entiende la escritura como una tecnología en sí misma y ante la digitalización el fenómeno supone un nuevo modelo comunicativo de tipo multidireccional. La comunicación científica en formato digital puede dar acceso en diferentes niveles, que se deben conocer con ritmos muy distintos a los de la época del papel (ejemplo cercano son las Licencias Creative Commons y las diversas formas de accesibilidad que suponen). Ese cambio de modelo comunicacional involucra como gran protagonista una metamorfosis del esquema cognitivo correspondiente. Visualizando la revista como un todo, debemos ir adaptando y reformulando los procesos cognitivos implicados para poder manejarnos en el nuevo escenario –que rápidamente se amplia y complejiza-. Todo un desafío que va mucho más allá de las formas, de los criterios de publicación, de los lenguajes y software que se deben conocer, requiere un nuevo esquema y arrastra con él una emocionalidad que se sitúa en otros vectores y unas perspectivas que se modifican más ágilmente y por tanto pueden generar zonas grises y de inseguridad, personales y de equipos, que se pueden llegar a plasmar en la propia publicación.
El escenario delineado es desafiante y ofrece muchísimas oportunidades que, para quienes vienen de un modelo comunicacional unidireccional, involucra asumir la adquisición personal y de equipo de una nueva manera. Requiere de una etapa de transición que debería ser contemplada en los planes de trabajo de las publicaciones y asumida para los cambios que indefectiblemente se deben hacer.
Tal vez deberíamos haber dicho “desde el Dios egipcio Thoth –a quienes atribuían la creación de la escritura- hasta la era digital”. En esta fase de Ciencias Psicológicas, en ese proceso de transformación y aceptación del desafío el terreno más difícil fue el cambio del esquema cognitivo, lo demás es, como siempre, aprender a hacer, trabajar e ilusionarnos –eso no cambia- y agradecer.