bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment refractory acute necrotizing myelitis after COVID-19 vaccine injection: a case report
Authors: Rezvani Majid , Mahmoodkhani Mehdi , Sourani Arman , Sharafi Mohammad , Foroughi Mina , Baradaran Mahdavi Sadegh , Sourani Armin , Nik Khah Roham , Veisi Shaahin 
Published: January 2024

Introduction and importance:
Post-vaccination myelitis is a rare and debilitating clinical situation. There are few reports of post-COVID-19 infection and vaccination neurological sequela.

Case presentation:
A 69-year-old lady was admitted to the emergency department due to weakness and hypoesthesia in her hands 1 week after the Sinopharm vaccine injection. MRI showed a cervicothoracic cord haemorrhagic lesion that deteriorated within 48 h. The clinical course was refractory to conservative treatments. She underwent an emergency cervical laminectomy as a salvage treatment. Intraoperative samples were in favour of acute necrotizing myelitis.

Discussion:
In the review of the literature, the inflammatory storm, vasculitis, and many unknown etiologies are deemed to be the possible causes of encephalopathy and myelitis after COVID-19 infection and vaccination. There are few cases of post-COVID-19 myelitis and hematomyelia, but this case was the first report of post-vaccination necrotizing myelitis.

Conclusion:
Post-vaccination necrotizing myelitis is a lethal medical situation requiring intensive and emergent neurosurgical vigilance. Early clinical diagnosis in the beginning and full neurosurgical-neurological treatment armamentarium options are cornerstones of treatment paradigms. Salvage treatment options such as extensive laminectomy may play a life-saving role in treatment refractory cases of acute necrotizing myelitis.
Establishment and characterization of the gemcitabine-resistant human gallbladder cancer cell line NOZ GemR
Authors: Xu Ming , Xu Song , Jiang Bowen , Man Zhongran 
Published: January 2024

Background:
Patients with gallbladder cancer (GBC) generally receive gemcitabine as the standard treatment; however, its efficacy is often limited owing to the development of resistance.

Methods:
To identify the mechanisms underlying gemcitabine resistance in GBC, a gemcitabine-resistant GBC cell line (NOZ GemR) was established by exposing the parental NOZ cell line to increasing concentrations of gemcitabine. Morphological changes, growth rates, and migratory and invasive capabilities were evaluated. Protein expression was detected using western blotting.

Results:
The results demonstrated that the IC50 of NOZ and NOZ GemR was 0.011 and 4.464 μM, respectively, and that the resistance index ratio was 405.8. In comparison, NOZ GemR cells grew slower and had significantly lower migration and invasion abilities than NOZ cells. There were altered levels of epithelial-mesenchymal transformation markers in NOZ GemR cells, as well as increased levels of the Akt/mTOR pathway protein.

Conclusion:
The NOZ GemR cell line could be used as an effective in vitro model to improve our understanding of gemcitabine resistance in GBC.
Hyper-IgE syndrome: a case report
Authors: Dave Tirth , Tashrifwala Fatema Ali Asgar , Rangwala Umme Salma , Hameed Rizwanullah 
Published: January 2024

Introduction and importance:
Hyper-IgE syndrome (HIES), also known as Job syndrome, is a rare primary immunodeficiency disorder characterized by elevated serum IgE levels, recurrent infections, and various clinical features. Early diagnosis, prompt management of infections, and supportive care are essential in improving outcomes for individuals with HIES. Genetic testing, including STAT3 gene sequencing, plays a crucial role in confirming the diagnosis. Further research is needed to enhance our understanding of HIES and develop targeted therapies to improve the quality of life for affected individuals.

Case presentation:
This case report presents the clinical features and management of a 37-year-old male with HIES, diagnosed at the age of 2 due to recurrent cold abscesses caused by Staphylococcal infections.

Clinical discussion:
The patient exhibited typical symptoms of HIES, including recurrent eczema, frequent bacterial infections, mucocutaneous candidiasis, and various physical abnormalities. Diagnostic markers such as elevated IgE levels and eosinophilia supported the HIES diagnosis, which was further confirmed by the identification of a STAT3 gene mutation. Treatment primarily involved supportive measures and antibiotics for infections. The patient’s blood test results and imaging findings revealed abnormalities such as low red blood cell count, elevated erythrocyte sedimentation rate, and pulmonary nodules.

Conclusion:
This case report highlights the importance of early diagnosis, prompt management of infections, and the need for ongoing research to improve our understanding and treatment of HIES.
Perceptions of physical activity among individuals with limb loss: A qualitative study
Authors: MacKay Crystal , Hitzig Sander L. , Mayo Amanda L. , Devlin Michael , Dilkas Steven , Marinho-Buzelli Andresa , Lee Leanna 
Published: January 2024

Objectives:
Individuals with lower-limb amputations (LLA) often have deficits in balance and community walking ability. As a result, people with LLA are often sedentary. The aim of this study was to explore perceptions of physical activity from the perspective of people with LLA.

Methods:
A qualitative descriptive study situated within an interpretive research paradigm was conducted. Semistructured interviews were held by telephone or in person with adults living with major LLAs recruited from rehabilitation hospitals and advertisements on social media. Individuals were included if they were age 18 years and older with a major LLA. Purposive sampling was used to ensure variation by sex, cause, and level of amputation.

Results:
Thirty-three people with LLA participated (22 men/11 women; median age 63 years). The majority of individuals had a unilateral, transtibial amputation (∼50% dysvascular LLA). Three main themes were developed to characterize participants’ perceptions of physical activity: (1) physical activity is perceived as important but can be challenging after amputation; (2) physical activity has physical and mental health benefits; and (3) physical activity is a means to maintain independence and engagement in community and social life.

Conclusions:
Obtaining the perspectives of individuals with LLA about physical activity helps us understand how they think about it, what motivates them, and how we can optimize physical activity levels. Future research is needed to evaluate the effectiveness of interventions to enhance physical activity in this population.
A Comparison of 18F-FDG PET/CT and 68Ga-PSMA PET/CT in Detecting Osteonecrosis of the Jaw in a Patient With Prostate Cancer
Authors: Öztürk Ahmet Ertuğrul , Şahin Rahime , Ergül Nurhan , Çermik Tevfik Fikret , Arslan Esra 
Published: January 2024

Abstract
Medication-related osteonecrosis of the jaw (ONJ) is rare adverse effect of zoledronic acid. We present ONJ detected in a 65-year-old man with prostate cancer who underwent 18F-FDG PET/CT for metabolic characterization and to exclude a second primary malignancy of the liver lesion observed in 68Ga-PSMA PET/CT. ONJ has high metabolic activity on 18F-FDG PET/CT and no PSMA receptor activation on the 68Ga-PSMA PET/CT. In this case, we wanted to underline the importance of 18F-FDG PET/CT imaging of medication-related ONJ in patients receiving zoledronic acid therapy and to emphasize that rapid and appropriate treatment can be provided.
The Curious Case of the Missing Limb on FDG PET Imaging
Authors: Tay Wan Jiun , Teh Daniel Jing Wen , Qin Yan , Lam Winnie Wing-Chuen 
Published: January 2024

Abstract
A 58-year-old woman with poorly controlled diabetes, peripheral vascular disease, and end-stage renal disease requiring hemodialysis was referred for 18F-FDG PET/CT to evaluate for source of sepsis. She had history of prior left forefoot and right second toe amputation, as well as left lower-limb dry gangrene for which she declined surgical management. We present a case of a nonamputated lower limb demonstrating regions of absolute photopenia, consistent with dry gangrene.
Hyalinizing Clear Cell Carcinoma in the Sphenoid Sinus
Authors: Takamura Toshiya , Koyasu Sho , Sugimoto Akihiko , Yamamoto Takayuki , Nakamoto Yuji 
Published: January 2024

Abstract
A 39-year-old man presented with a 1-month history of headaches. Imaging revealed a mass with extensive destruction. T2-weighted imaging displayed mixture of low and sponge-like high intensities and also dark area, with FDG PET/CT showing uneven but intense accumulation. Biopsy confirmed EWSR1 rearrangement, and hyalinizing clear cell carcinoma (HCCC) was diagnosed. HCCC, recently renamed from clear cell carcinoma in the fifth edition of the World Health Organization Classification of Head and Neck Tumors, is a rare tumor. This case describes the features of T2-weighted imaging and FDG PET patterns in HCCC, possibly contributing to their consideration in the differential diagnosis.
Long-Term Improvement of Crow's Feet Wrinkles in Combination With Cervicofacial and Temporal Lifting
Authors: Atiyeh Bishara , Ghanem Odette Abou , Oneisi Ahmad , Chalhoub Rawad 
Published: January 2024

Background
The lateral orbital crow's feet area is one for which rejuvenation is most frequently requested by patients. Moreover, lateral canthal wrinkles are a common source of dissatisfaction after rhytidoplasty. Botulinum toxin injection has emerged as a most popular, easy, and effective solution; nevertheless, repeated injections are required periodically for long-term effect. Other nonsurgical options have also been described to have some demonstrable advantages. Orbicularis oculi surgical manipulations have been described as well.

Material and Methods
A systematic PubMed literature search was conducted to identify clinical cohort studies including more than 10 patients describing surgical approaches for improvement of crows' feet wrinkles in combination with face and/or temporal lifts. The search was complemented by Embase, Medline, and Cochrane searches in addition to screening of reference lists of selected studies and simple term searches about surgical treatment of crow's feet.

Results
Fourteen studies satisfied the inclusion criteria and were included in this review describing various muscle excision techniques including vertical strip excision, lateral partial resection, wedge resection, muscle resection in “C” pattern, and enlarged myectomy of about one-third of the whole orbital extension in addition to muscle manipulation modalities, including muscle splaying, muscle division, muscle division and splaying, muscle undermining with partial denervation, and muscle suspension. Interposition of fascia between orbicularis muscle and overlying skin was also reported.

Conclusion
View the few studies retrieved and the wide spectrum of reported techniques, it is not possible to determine from this review the most effective modality. Nevertheless, it seems that subcutaneous undermining of the lateral canthal area combined with splaying and traction of the orbicularis oculi muscle and fixation to the temporalis fascia with or without muscle division would yield the best long-term results. This review indicates also that surgical correction of crow's feet during rhytidectomy or temporal lift could be a positive complement to improve aesthetic outcome. Unfortunately, if not underreported, it is definitely neglected. We believe that this review may be an eye-opener for surgeons.
Cancer survivor late-effects, chronic health problems after cancer treatment: what’s the evidence from population and registry data and where are the gaps?
Authors: Faithfull Sara , Greenfield Diana 
Published: January 2024

Purpose of review
Improvements in cancer treatment have led to more people living with and beyond a cancer diagnosis but survivors may have increased health problems as they age. The purpose of this review is to critically evaluate population data exploring incidence of late effects for cancer survivors.

Recent findings
18 studies were identified between 2013 and 2023 that explored the impact on survivors’ physical and emotional health. Patients who had been treated at least 2 years previously for cancer had significant cardiovascular risk factors compared with age-matched controls. Women with breast cancer were more likely to have cardiovascular disease, including hypertension, arrythmias and congestive heart failure. This was associated with anthracyclines and/or trastuzumab as part of systemic anti-cancer therapy. Survivors of colorectal cancer were three times more likely to have acute kidney injury than age-matched controls. Stress and mood disorders were higher in survivors of testicular cancer and prostate cancer.

Summary
Population studies are important to identify the ‘real world’ consequences of cancer and its treatment beyond clinical trials. Knowledge is critical for managing an ageing cancer population. Data to personalise cancer survivorship care, not only helps determine potential health risks, but can improve secondary prevention, emotional health, recovery, and long-term outcomes.
Unveiling Neurobrucellosis: A Case Report Emphasizing Early Diagnosis for Better Outcomes
Authors: SIVAKUMAR HARIPRIYA , MALHOTRA SHIKHIR , GADEPALLI RAVISEKHAR , TAK VIBHOR , KUMAR BHARAT 
Published: January 2024

Introduction:Brucellosis is a pervasive zoonotic disease causing considerable human morbidity worldwide. This report focuses on a case of Neurobrucellosis in a rural Indian patient, emphasizing the need for timely microbiological confirmation given its nonspecific clinical presentation.
Case Presentation: A 55-year-old rural Indian farmer presented with a three-week history of insidious, low-grade fever, myalgia, and arthralgia. He developed acute right-sided weakness and neurological symptoms, including disorientation and neck rigidity. Laboratory tests indicated abnormal blood counts, elevated inflammatory markers, and liver dysfunction. Cerebrospinal fluid analysis showed pleocytosis with lymphomononuclear cells and elevated protein levels. Blood cultures eventually grew Gram-negative coccobacilli. Serological tests confirmed neurobrucellosis. Prompt antibiotic therapy led to clinical and laboratory improvement.
Conclusion: This case underscores the importance of recognizing neurobrucellosis, particularly in endemic areas, given its nonspecific clinical presentation. Early microbiological diagnosis, supported by positive blood cultures and serological tests, was crucial. The patient's rapid response to appropriate antibiotics emphasizes the significance of timely recognition and management.
Shoppre’s dilemma with marketplace launch – Do it sooner, delay for later or dismiss forever?
Authors: Varghese Ann Mary , Jacob Remya Tressa , Narayanamurthy Gopalakrishnan 
Published: January 2024

Learning outcomes
After completing the case study, the students will be able to explore, create and capture the dilemmas of a platform strategy; compare, contrast and configure strategies for successful platform adoption; develop fitting configurations for marketplace design; and use temple framework to evaluate the dilemma of the element of time (do it sooner, delay for later or dismiss forever) in launching a new marketplace.

Case overview/synopsis
Shoppre was a parcel-forwarding firm established in 2017. In a short period, Shoppre turned out to be one of the best parcel forwarding and cross-border commerce companies in India, thanks to the first-mover advantage it enjoyed. Shoppre had offerings of shopping and shipping of cross-border e-commerce. As a new firm looking forward to increasing its market power, Shoppre faced the dilemma of whether to launch the marketplace, and if yes, whether to do it soon or delay it for the future. There was also confusion in the marketplace’s design and implementation. Nikkitha Shankar’s (she/her) worry was that if Shoppre did not decide quickly on this, there would be possible crises in managing the partners and their financial performance. Shankar was brainstorming the issues with the founding partner and was gauging the dimensions. This case study presented new marketplaces’ dilemmas along with managing sellers, customers, markets, finance, logistics and digital transformation.

Complexity academic level
The case study is suitable for undergraduate- and graduate-level students pursuing courses in business programmes and senior management professionals participating in executive education programmes. The case study will also fit well for courses such as the “Platform strategy: building and thriving in a vibrant ecosystem” course [1], digital business models [2] and digital business strategy [3].

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
Does joining online groups increase farmers' incomes in the mountainous areas of northern Vietnam? The role of information
Authors: Doanh Nguyen Khanh 
Published: January 2024

PurposeThis study analyzes whether farmers' incomes increase as they participate in online groups.Design/methodology/approachThe study analyzed interview data from 673 farming households in three mountainous provinces of northern Vietnam, utilizing the propensity score matching (PSM) method.FindingsThe empirical results reveal that farmers participating in online groups, particularly those engaged in 1–3 groups, experience an increase in their income attributed to the three advantages of sharing-accessing-saving (SAS) information. Farming households engaged in online groups earn higher incomes, ranging from equivalent to 25.78 to 26.96 USD, in comparison to those who do not participate. Notably, farmers participating in 1–3 online groups outpace their counterparts in 4–5 groups in terms of income.Research limitations/implicationsThis study exclusively focuses on examining farmers' total income derived from all their agricultural activities and does not quantify the specific impact of online group participation on the income generated by each product. Furthermore, it is important to note that the PSM method has the potential to introduce bias due to unobserved factors, such as social networks and local culture. Consequently, future research should prioritize the segmentation of income from individual agricultural products, distinct from the overall income, to gain a more nuanced understanding of each product’s sensitivity to information exchanged in online groups. Simultaneously, accounting for unobserved factors is crucial to obtain unbiased estimates.Originality/valueThis study represents the inaugural exploration into the comparison of farmers' incomes within a novel context – participation in digital-based groups. Furthermore, it extends the inquiry by delving into the correlation between the number of online groups joined and farmers' income. The empirical findings indicate that farmers may benefit the most by limiting their participation to a select few groups that align with their information needs and analytical abilities.
Does tax disclosure in Global Reporting Initiative (GRI)-based sustainability reporting mitigate aggressive tax avoidance? Evidence from a developing country
Authors: Rudyanto Astrid 
Published: January 2024

Purpose
This paper aims to examine whether tax disclosure in Global Reporting Initiative (GRI)-based sustainability reporting mitigates aggressive tax avoidance.

Design/methodology/approach
This study uses a multiple regression method for 714 nonspecially taxed firms listed on the Indonesia Stock Exchange in 2014–2018.

Findings
The findings demonstrate that disclosing tax payments in GRI-based sustainability reports reduces aggressive tax avoidance. Additional analysis indicates that the number of GRI-based sustainability reports positively affects aggressive tax avoidance. However, disclosing tax payments in multiple GRI-based sustainability reports negatively affects aggressive tax avoidance.

Originality/value
Recent prior studies demonstrate that aggressive tax avoidance does not indicate an organizational culture that devalues corporate social responsibility. This paper argues that firms cannot find the link between tax and corporate social responsibility when tax payments are not incorporated in sustainability reports. GRI considers tax a sustainability issue and seeks to institutionalize this concept by recommending that firms disclose taxes in their sustainability reports. This research analyses whether disclosing taxes in GRI-based sustainability reports may serve as a form of soft law by convincing firms that tax is a sustainability issue, thereby reducing their tax avoidance. This topic has received little attention in previous research.
Forecasting value-at-risk and expected shortfall in emerging market: does forecast combination help?
Authors: Le Trung Hai 
Published: January 2024

PurposeThis paper investigates how various strategies for combining forecasts, both simple and optimised approaches, are compared with popular individual risk models in estimating value-at-risk (VaR) and expected shortfall (ES) in emerging market at alternative risk levels.Design/methodology/approachUsing the case study of the Vietnamese stock market, the author produced one-day-ahead VaR and ES forecast from seven individual risk models and ten alternative forecast combinations. Next, the author employed a battery of backtesting procedures and alternative loss functions to evaluate the global predictive accuracy of the different methods. Finally, the author investigated the relative performance over time of VaR and ES forecasts using fluctuation test.FindingsThe empirical results indicate that, although combined forecasts have reasonable predictive abilities, they are often outperformed by one individual risk model. Furthermore, the author showed that the complex combining methods with optimised weighting functions do not perform better than simple combining methods. The fluctuation test suggests that the poor performance of combined forecasts is mainly due to their inability to cope with periods of instability.Research limitations/implicationsThis study reveals the limitation of combining strategies in the one-day-ahead VaR and ES forecasts in emerging markets. A possible direction for further research is to investigate whether this finding holds for multi-day ahead forecasts. Moreover, the inferior performance of combined forecasts during periods of instability motivates further research on the combining strategies that take into account for potential structure breaks in the performance of individual risk models. A potential approach is to improve the individual risk models with macroeconomic variables using a mixed-data sampling approach.Originality/valueFirst, the authors contribute to the literature on the forecasting combinations for VaR and ES measures. Second, the author explored a wide range of alternative risk models to forecast both VaR and ES with recent data including periods of the COVID-19 pandemic. Although forecast combination strategies have been providing several good results in several fields, the literature of forecast combination in the VaR and ES context is surprisingly limited, especially for emerging market returns. To the best of the author’s knowledge, this is the first study investigating predictive power of combining methods for VaR and ES in an emerging market.