bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recombinant Factor VIIa in the Treatment of Non-Hemophiliac Bleeding
Authors: Lam Masha SH , Sims-McCallum Rosalyn P 
Published: March 2005

OBJECTIVE: To review the clinical evidence for the use of recombinant factor VIIa (rFVIIa) in the prevention and/or treatment of bleeding in non-hemophiliac patients. DATA SOURCES: A MEDLINE search (1966–December 2004) was conducted to identify pertinent literature. Results were limited to English-language reports and clinical trials. References of relevant articles and selected abstracts presented at scientific meetings were also reviewed. STUDY SELECTION AND DATA EXTRACTION: Human data from prospective and retrospective studies that examined the hemostatic effect of rFVIIa in non-hemophiliac patients were reviewed, with a focus on surgical prophylaxis, liver disease, intractable bleeding associated with trauma and surgery, and anticoagulation reversal. DATA SYNTHESIS: Results from limited controlled trials on the use of rFVIIa as an adjunct for prevention of bleeding in surgery and liver diseases have not been consistent. For treatment of intractable bleeding, earlier use of rFVIIa in one trauma trial was shown to decrease the number of blood transfusions, but no differences in terms of clinical outcomes were observed in all trials. Controlled trials do not suggest an increased risk of thrombotic events. Optimal dosing and timing of administration have yet to be defined. CONCLUSIONS: Until further prospective controlled data are available, it is recommended that conventional intervention for prevention and control of hemorrhage in non-hemophiliac patients should remain the standard of care. Close monitoring of coagulation parameters is recommended before, during, and after therapy, especially in high-risk patients. Pharmacoeconomic analysis may be useful to help control costs and maximize clinical benefits.
On homosexualities in Latin America (and other places)
Authors: Lancaster Roger N. 
Published: March 2005

De Los Otros: Intimacy and Homosexuality Among Mexican Men. JOSEPH CARRIER. NY: Columbia University Press, Between Men— Between Women: Lesbian and Gay Studies. Lillian Faderman and Larry Gross, eds., 1995. xiv + 231 pp., references, appendix, index.Latin American Male Homosexualities. STEPHEN O. MURRAY with additional contributions by Manuel Arboleda G. etal. Albuquerque: University of New Mexico Press, 1995. xvi + 304, references.
Wedding bell blues: Marriage, missing men, and matrifocal follies
Authors: Blackwood Evelyn 
Published: March 2005

ABSTRACTIn this article, I revisit debates about so‐called matrifocal societies as a way to critique the centrality of heteronormative marriage and family in anthropology. Using gender as a tool of analysis, I argue that anthropologists have relied on the trope of the dominant heterosexual man, what I call the “Patriarchal Man,” to create and sustain concepts of “marriage” and “family.” By examining the discourse on matrifocality in studies of Afro‐Caribbean and Minangkabau households, I show how it is the “missing man,” the dominant heterosexual man, who is the key to the construction and perpetuation of the matrifocal concept and, by extension, the motor of marriage, family, and kinship. This fixity on the dominant heterosexual man has led anthropologists to misrecognize other forms of relatedness as less than or weaker than heteronormative marriage. I suggest that, rather than positing a foundational model for human sociality, intimacy, or relatedness, researchers look for webs of meaningful relationships in their historical and social specificity.
Cobo and tabua in Fiji: Two forms of cultural currency in an economy of sentiment
Authors: Arno Andrew 
Published: March 2005

ABSTRACTCultural currency, defined in performance terms, is a highly specific medium for the deployment of sentiment in community life, and it can be usefully compared with varieties of material currency. Sentiment, as a cultural system, is an intellectual rather than a material property, and, like all property, it is defined by social relationships and obligations. Cultural currencies are performances that are constrained in use by meaning and identity, rather than by physical possession. Research on the cobo and tabua in Fiji represents an ethnographic case study of cultural currency that has implications for investigating the relationships among culture, sentiment, property, and mode of production generally.
Microhydrodynamic analysis of nanogrinding in stirred media mills
Authors: Eskin D. , Zhupanska O. , Hamey R. , Moudgil B. , Scarlett B. 
Published: March 2005

AbstractThe dynamics of the milling media in a turbulent flow is considered. The mean velocity of the milling beads is calculated on the assumption that the power spent on stirring is transferred into the energy of turbulent eddies. The energy spent on stirring dissipates as a result of media–liquid viscous friction, lubrication, and by inelastic collisions of the beads with each other. The maximum force at which the milling beads can compress particles between them is calculated by the Hertzian theory of elastic impact. The frequency of compressions for a single particle is evaluated by probabilistic analysis. A criterion of milling efficiency, based on calculating the energy spent on the plastic particle deformation, is proposed. A numerical study of the milling bead dynamics and their interactions with the particles in the mixing tank is performed. The numerical results are in qualitative agreement with the experimental data. Both the numerical and experimental analyses show that, from the perspective of hydrodynamics, an optimization of stirred media mills can be achieved by choosing the optimum size and concentration of the milling media. © 2005 American Institute of Chemical Engineers AIChE J, 2005
PBM and activated sludge flocculation: From experimental data to calibrated model
Authors: Nopens I. , Koegst T. , Mahieu K. , Vanrolleghem P. A. 
Published: March 2005

AbstractA new comprehensive calibration methodology for a population balance model (PBM) is presented using experimental size distribution data obtained on‐line during flocculation tests. It was found that the moving‐pivot discretization technique should be used to accurately solve the PBM. A new methodology for grid transformation and volume to number transformation, based on the sludge concentration and the densities of liquid, solids, and flocs, is presented. Model fits were performed on four different fitting variables. Volume‐based fitting (vol % and D[4, 3]) tends to fit the middle part of both the vol % and number distribution better than the tails of smaller and larger particle sizes. Severe underpredictions (up to a factor of 30) of the lower‐size classes are observed at steady state. Number‐based fitting [(weighted) number distribution] tends to fit the small‐size classes better, but still underpredicts them by a factor of 2 at steady state. © 2005 American Institute of Chemical Engineers AIChE J, 2005
Statistical modelling of functional data
Authors: Besse Philippe C. , Cardot Hervé , Faivre Robert , Goulard Michel 
Published: March 2005

AbstractThis paper presents some statistical models and estimation procedures when the explanatory variables are functions. We put the stress on the fact that regularization techniques are needed in order to get stable and reliable estimations. Then, an application in remote sensing in presented. It shows the potential of these kind of models to handle real life problems. Copyright © 2005 John Wiley & Sons, Ltd.
Outpatient coronary angioplasty: Feasible and safe
Authors: Slagboom Ton , Kiemeneij Ferdinand , Laarman Gert Jan , van der Wieken Ron 
Published: March 2005

AbstractThis study tested the safety and feasibility of coronary angioplasty on an outpatient basis. The purpose of this approach includes cost‐effectiveness and patient comfort. Six hundred forty‐four patients were randomized to either transradial or transfemoral PTCA using 6 Fr equipment. Patients were triaged to outpatient management based on a predefined set of predictors of an adverse outcome in the first 24 hr after initially successful coronary angioplasty. Three hundred seventy‐five patients (58%) were discharged 4–6 hr after PTCA; 42% stayed in hospital overnight. In the outpatient group, one adverse event occurred (subacute stent thrombosis 7 hr postdischarge, nonfatal myocardial infarction). There were no major vascular complications. In the hospital group, 19 patients (7%) sustained an adverse cardiac even in the first 24 hr; 1 patient died. Patients treated via the femoral route had more (minor) bleeding complications (19 patients; 6%); in 17 of these, this was the sole reason that discharge was delayed. PTCA on an outpatient basis, performed via the radial or the femoral artery with low‐profile equipment, is safe and feasible in a considerable part of a routine PTCA population. A larger proportion of transradial patients can be discharged due to a reduction in (minor) bleeding complications. Catheter Cardiovasc Interv 2005;64:421–427. © 2005 Wiley‐Liss, Inc.
Syntheses and Properties of Metal‐Centered Mixed‐Valent [NEt4]{MnII⊂[MnII3MnIII3Cl6(L)6]} Manganese Wheels
Authors: Saalfrank Rolf W. , Nakajima Takayuki , Mooren Nicolai , Scheurer Andreas , Maid Harald , Hampel Frank , Trieflinger Christian , Daub Jörg 
Published: March 2005

AbstractUpon reaction of N‐substituted diethanolamines H2L2–4 (4, 6, 7) with cesium carbonate and bis(tetraethylammonium) tetrachloromanganate(II) in acetonitrile in the presence of air, the metal‐centered mixed‐valent manganese wheels [NEt4]{MnII⊂[MnII3MnIII3Cl6(L2–4)6]} (8–10) were generated. X‐ray crystallographic structure analyses revealed, that 8–10 are principally isostructural and consist of an alternating ring of three MnII and three MnIII ions, centered by an additional MnII ion. The cyclic voltammograms of 8 and 10 displayed three quasi‐reversible oxidation processes, which are attributed to the subsequent one electron‐oxidations of the three peripheral MnII ions to MnIII. Oxidation of the central MnII ion is not observed within the applied potential. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Ordered Meso‐ and Macroporous Binary and Mixed Metal Oxides
Authors: Carreon Moises A. , Guliants Vadim V. 
Published: March 2005

AbstractThe caption of Figure 8 on page 32 of the original article[1] was reporduced incompletely; the correct caption should read as follows: Figure 8. Nitrogen adsorption−desorption isotherms and BJH pore‐size distribution plot (inset) for mesoporous niobium oxide (L. Yuan, V. V. Guliants, unpublished data).
Effect of argon‐plasma treatment on proliferation of human‐skin–derived fibroblast on chitosan membrane in vitro
Authors: Zhu Xiao , Chian Kerm Sin , Chan‐Park Mary Bee Eng , Lee Seng Teik 
Published: March 2005

AbstractChitosan is not only a nontoxic, biocompatible, and biodegradable polymer, but has also a chemical structure similar to glycosaminoglycans (GAGs), which promote scarless wound healing of skin. In this study, chitosan membranes were treated with argon plasma to improve their surface hydrophilicity. The results showed that the water contact angles of these surface‐treated membranes were significantly reduced from 60.76 to 11.57°. The total surface energy was increased from 41.06 to 67.31 mJ/m2, with 60–86.95% improvement in the gamma‐negative component and a 20% difference in the nonpolar component. Argon‐plasma–treated chitosan membranes exhibited excellent attachment, migration, and proliferation of the human‐skin–derived fibroblasts (hSFs) compared to the untreated ones. It was found that the duration of argon‐plasma treatment influenced the cell proliferation, and the optical densities in MTT assay were enhanced. Argon‐plasma treatment improved the surface hydrophilicity of chitosan membranes and promoted the attachment and proliferation of hSFs. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res 73A: 264–274, 2005
Photocatalytic and photoelectrochemical performance of crystallized titanium dioxide sol with neodymium ion modification
Authors: Xie Yibing , Yuan Chunwei 
Published: March 2005

AbstractTitanium dioxide was modified with neodymium metal ion by a wet‐chemical coprecipitation–peptization technique under low temperature to produce crystallized sol catalyst (Nd3+TiO2). Crystal structure was characterized by X‐ray diffraction measurement. Sol particle size was studied by means of particle size distribution measurement. Surface hydroxyl groups were determined using Fourier transform infrared spectroscopy. Photocatalytic reactivity of sol photocatalysts was investigated under ultraviolet and visible light irradiation. Photodegradation and photomineralization under ultraviolet and visible light excitation were studied in the TiO2 and Nd3+TiO2 hydrosol reaction system. A photocurrent–time spectrum was also applied to characterize the electron‐transferring efficiency in the process of self‐sensitization and dye‐sensitization photocatalysis reactions. As an application approach of sol catalyst, Nd3+TiO2 sol was coated on a diffusing optical fibers bundle and the photocatalytic reaction was investigated in the immobilization fiber reactor. Copyright © 2005 Society of Chemical Industry
Liquid–liquid extraction of cadmium(II) by Cyanex 923 and its application to a solid‐supported liquid membrane system
Authors: Rodríguez Ana María , Gómez‐Límón Dulce , Alguacil Francisco José 
Published: March 2005

AbstractThe extraction of cadmium(II) by Cyanex 923 (a mixture of alkylphosphine oxides) in Solvesso 100 from hydrochloric acid solution has been investigated. The extraction reaction is exothermic. The numerical analysis of metal distribution data suggests the formation of CdCl2.2L, HCdCl3.2L and H2CdCl4.2L (L = ligand) in the organic phase. The results obtained for cadmium(II) distribution have been implemented in a solid‐supported liquid membrane system. The influences of feed phase stirring speed (400–1400 min−1), membrane composition (carrier concentration: 0.06–1 mol dm−3) and metal concentration (0.01–0.08 g dm−3) on cadmium transport have been investigated. Copyright © 2005 Society of Chemical Industry
Activation of extracellular signal‐regulated kinase 5 may play a neuroprotective role in hippocampal CA3/DG region after cerebral ischemia
Authors: Wang Rui‐Min , Zhang Quan‐Guang , Li Chun‐Hong , Zhang Guang‐Yi 
Published: March 2005

AbstractExtracellular signal‐regulated kinase 5 (ERK5), the newest member of the mitogen‐activated protein (MAP) kinase family of proteins, is widely expressed in many tissues, including the brain. Here we investigated the activation and subcellular localization of ERK5 by immunoblotting and immunohistochemistry as well as its potential role following cerebral ischemia in rat hippocampus. Transient cerebral ischemia was induced by the four‐vessel occlusion method in Sprague‐Dawley rats. Our results first indicated that the strongly activated ERK5 immunoreactivity was seen in the CA3/DG region but not in the CA1 pyramidal cell of rat hippocampus following reperfusion. In cytosol extracts, ERK5 activation was rapidly increased, with a peak at 30 min, and then gradually decreased to basal level at 3 days of reperfusion. In nucleus extracts, both phospho‐ERK5 and its protein expression were persistently enhanced during the later reperfusion period (from 6 hr to 3 days). To elucidate further the possible role of ERK5 activation and subcellular localization in ischemic insult, rats were intraperitoneally administrated with nifedipine (ND) and dextromethorphan (DM), inhibitors of two types of calcium channels, 20 min prior to ischemia. Our findings showed that ND or DM significantly reduced activated ERK5 immunoreactivity in the nucleus and that most of the CA3/DG neurons were lost 3 days later. Most importantly, intracerebroventricular infusion of ERK5 antisense oligonucleotides (AS; every 24 hr for 3 days before ischemia), but not sense oligonucleotides or vehicle, not only markedly decreased the level of ERK5 and p‐ERK5 but also largely caused neuronal loss in the CA3/DG region at 3 days of reperfusion. Taken together, the results strongly suggest that ERK5 was selectively activated in the hippocampal CA3/DG region and subsequently translocated from the cytosol to the nucleus through activation of N‐methyl‐D‐aspartate receptor and L‐type voltage‐gated calcium channel, which might act as an important survival signal in ischemia‐induced neuronal cell damage of the CA3/DG region. © 2005 Wiley‐Liss, Inc.
Temporal and spatial distribution of growth‐associated molecules and astroglial cells in the rat corticospinal tract during development
Authors: Hsu Jung‐Yu C. , Stein Stuart A. , Xu Xiao‐Ming 
Published: March 2005

AbstractTo understand better the role of growth‐promoting and ‐inhibiting molecules in the development of the corticospinal tract (CST), temporospatial expression of embryonic neural cell adhesion molecule (E‐NCAM), growth‐associated protein‐43 (GAP‐43), and chondroitin sulfate proteoglycan (CSPG) was studied in developing rats. Transverse sections of the seventh cervical (C7), seventh thoracic (T7), and fourth lumbar (L4) segments were examined at postnatal days (P) 2, 6, 10, 14, and 28. The highest E‐NCAM immunoreactivity appeared at the C7 level on P2 and shifted caudally to the T7 on P6 and L4 on P10, which correlated closely with the time course of CST development. The peak expression of GAP‐43 emerged at C7 on P2 and shifted to the T7 and L4 levels at a relatively lagging pace compared with that of E‐NCAM. Conversely, a transient reduction in CSPG immunoreactivity was found within the CST at the C7 level on P2, T7 level on P6, and L4 level on P10, corresponding well with the arrival of CST‐leading axons at these levels. Interestingly, higher levels of CSPG were found to surround the growing CST, suggesting a repulsive environment that channels the growth of CST. Moreover, a transition from immature to mature astrocytes in a rostrocaudal direction during CST development was evidenced by anti‐vimentin and anti‐glial fibrillary acidic protein (GFAP) immunostaining, suggesting a guidance role of immature astroglia in axonal outgrowth. Our study thus demonstrated dynamic changes of multiple growth‐related molecules and astroglial environment that contribute to postnatal development of the CST. © 2005 Wiley‐Liss, Inc.
Ultrafast synthesis of poly(methyl acrylate) and poly(methyl acrylate)‐b‐poly(vinyl chloride)‐b‐poly(methyl acrylate) by the Cu(0)/tris(2‐dimethylaminoethyl)amine‐catalyzed living radical polymerization and block copolymerization of methyl acrylate initiated with 1,1‐chloroiodoethane and α,ω‐Di(iodo)poly(vinyl chloride) in dimethyl sulfoxide
Authors: Percec Virgil , Guliashvili Tamaz , Popov Anatoliy V. 
Published: March 2005

AbstractABA block copolymers containing poly(methyl acrylate) (PMA) as the A segment and poly(vinyl chloride) (PVC) as the B segment (PMA‐b‐PVC‐b‐PMA) were synthesized by the Cu(0)/tris(2‐dimethylaminoethyl)amine (Me6‐TREN)‐catalyzed living radical block copolymerization of methyl acrylate (MA) initiated with α,ω‐di(iodo)poly(vinyl chloride) [α,ω‐di(iodo)PVC] in dimethyl sulfoxide (DMSO) at 90, 50, and 25 °C. 1,1‐Chloroiodoethane, a model compound for the chain ends of the α,ω‐di(iodo)PVC macroinitiator, was used as an initiator for the Cu(0)/Me6‐TREN‐catalyzed living radical polymerization of MA in DMSO at 70, 50, and 25 °C. Ultrafast block copolymerization and living radical polymerization methods for MA and other acrylates were discovered. These ultrafast methods provided access to the synthesis of PMA‐b‐PVA‐b‐PMA in reaction times, which depended on the temperature range, of 3–20 min. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1948–1954, 2005
Comparison of cell‐based and cell‐free protocols for producing target proteins from theArabidopsis thalianagenome for structural studies
Authors: Tyler Robert C. , Aceti David J. , Bingman Craig A. , Cornilescu Claudia C. , Fox Brian G. , Frederick Ronnie O. , Jeon Won Bae , Lee Min S. , Newman Craig S. , Peterson Francis C. , Phillips George N. , Shahan Mark N. , Singh Shanteri , Song Jikui , Sreenath Hassan K. , Tyler Ejan M. , Ulrich Eldon L. , Vinarov Dmitriy A. , Vojtik Frank C. , Volkman Brian F. , Wrobel Russell L. , Zhao Qin , Markley John L. 
Published: March 2005

AbstractWe describe a comparative study of protein production from 96Arabidopsis thalianaopen reading frames (ORFs) by cell‐based and cell‐free protocols. Each target was carried through four pipeline protocols used by the Center for Eukaryotic Structural Genomics (CESG), one for the production of unlabeled protein to be used in crystallization trials and three for the production of15N‐labeled proteins to be analyzed by1H‐15N NMR correlation spectroscopy. Two of the protocols involvedEscherichia colicell‐based and two involved wheat germ cell‐free technology. The progress of each target through each of the protocols was followed with all failures and successes noted. Failures were of the following types: ORF not cloned, protein not expressed, low protein yield, no cleavage of fusion protein, insoluble protein, protein not purified, NMR sample too dilute. Those targets that reached the goal of analysis by1H‐15N NMR correlation spectroscopy were scored as HSQC+ (protein folded and suitable for NMR structural analysis), HSQC± (protein partially disordered or not in a single stable conformational state), HSQC− (protein unfolded, misfolded, or aggregated and thus unsuitable for NMR structural analysis). Targets were also scored as X− for failing to crystallize and X+ for successful crystallization. The results constitute a rich database for understanding differences between targets and protocols. In general, the wheat germ cell‐free platform offers the advantage of greater genome coverage for NMR‐based structural proteomics whereas theE. coliplatform when successful yields more protein, as currently needed for crystallization trials for X‐ray structure determination. Proteins 2005. © 2005 Wiley‐Liss, Inc.
Addressing the intrinsic disorder bottleneck in structural proteomics
Authors: Oldfield Christopher J. , Ulrich Eldon L. , Cheng Yugong , Dunker A. Keith , Markley John L. 
Published: March 2005

AbstractThe Center for Eukaryotic Structural Genomics (CESG), as part of the Protein Structure Initiative (PSI), has established a high‐throughput structure determination pipeline focused on eukaryotic proteins. NMR spectroscopy is an integral part of this pipeline, both as a method for structure determinations and as a means for screening proteins for stable structure. Because computational approaches have estimated that many eukaryotic proteins are highly disordered, about 1 year into the project, CESG began to use an algorithm (the Predictor of Naturally Disordered Regions, PONDR®) to avoid proteins that were likely to be disordered. We report a retrospective analysis of the effect of this filtering on the yield of viable structure determination candidates. In addition, we have used our current database of results on 70 protein targets from Arabidopsis thaliana and 1 from Caenorhabditis elegans, which were labeled uniformly with nitrogen‐15 and screened for disorder by NMR spectroscopy, to compare the original algorithm with 13 other approaches for predicting disorder from sequence. Our study indicates that the efficiency of structural proteomics of eukaryotes can be improved significantly by removing targets predicted to be disordered by an algorithm chosen to provide optimal performance. Proteins 2005. © 2005 Wiley‐Liss, Inc.