bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional clinical assessment for MRONJ risk in oncologic patients following tooth extractions
Authors: Moreno Rabie Catalina , Cavalcante Fontenele Rocharles , Oliveira Santos Nicolly , Nogueira Reis Fernanda , Van den Wyngaert Tim , Jacobs Reinhilde 
Published: October 2023

Objectives
To identify clinical and local radiographic predictors for medication-related osteonecrosis of the jaws (MRONJ) by the assessment of pre-operative CBCT images of oncologic patients treated with anti-resorptive drugs (ARDs) undergoing tooth extractions.

Methods
This retrospective, longitudinal, case–control study included clinical and imaging data of 97 patients, divided into study and control group. Patients in the study group (n = 47; 87 tooth extractions) had received at least one dose of ARD, undergone tooth extraction(s), and had a pre-operative CBCT. An age-, gender-, and tooth extraction-matched control group (n = 50; 106 tooth extractions) was selected. Three calibrated, blinded, and independent examiners evaluated each tooth extraction site. Statistical analysis used χ2/Fisher’s exact/Mann–Whitney U test to contrast control and study group, ARD type used, and sites with or without MRONJ development. p-value ≤ 0.05 was considered significant.

Results
From the study group, 15 patients (32%) and 33 sites (38%) developed MRONJ after tooth extraction. When controls were compared to study sites, the latter showed significantly more thickening of the lamina dura, widened periodontal ligament space, osteosclerosis, osteolysis, and sequestrum formation. In the study group, MRONJ risk significantly increased in patients who had multiple tooth extractions, were smokers, and had shorter drug holidays. Periosteal reaction and sequestrum formation may indicate latent MRONJ lesions. Additionally, patients given bisphosphonates showed considerably more osteosclerosis than those given denosumab.

Conclusions
Periosteal reaction and sequestrum formation are suspected to be pre-clinical MRONJ lesions. Furthermore, ARD induced bony changes and radiographic variations between ARD types were seen.
Investigation of Acute Phase Proteins in Cattle Infected with Mycobacterium bovis
Authors: Çenesiz S , Şahin B , Akpinar RK , Kiliçoğlu Y 
Published: October 2023

Tuberculosis (TB) is a contagious and zoonotic disease that adversely affects human and animal health, caused by the formation of tubercules in a caseous character in the lungs, other tissues and organs. The causative of the disease is Mycobacterium bovis. An increase or decrease in acute phase protein (APP) levels is observed in various bacterial, viral and parasitic diseases in cattle. Therefore, in this study, it was aimed to determine the changes in the levels of AFPs in cattle infected with M. bovis. In the study, 26 tuberculosis suspected and 10 healthy cattle blood serums collected from various enterprises in Samsun were used. Rose bengal plate test and complement fixation test were applied in serum by taking blood into heparin containing tubes from vena jugularis of cattle. Whole blood samples were subjected to gamma interferon ELISA test. Haptoglobin (Hp), serum amyloid A (SAA), albumin and total protein (TP) levels, which are among the acute phase proteins, were determined in the blood serums taken from the groups. As a result of the analysis, when the AFP levels of the cattle infected with M. bovis and the cattle in the healthy group were compared, it was determined that haptoglobin (p < 0.01), serum amyloid A (p < 0.01) and total protein (p < 0.01) levels, which are AFPs increased statistically significantly compared to the healthy group, while the albümin (p > 0.05) level decreased, but there was no statistically significant difference.
Keywords: acute phase protein (APP); cattle; mycobacterium bovis; tuberculosis (TB),
Examining research systems and models for local government: a systematic review
Authors: Hock Emma S. , Scope Alison , Booth Andrew 
Published: October 2023

Background:
Local authorities (LA) are key in improving population health, and LA public health decision makers need support from appropriately organised research capacity; however, few models of LA research systems are known to exist.

Aims and objectives:
To explore potential and existing models of LA-based research systems.

Methods:
This mapping review and time-constrained systematic review synthesises conceptual and empirical literature from 12 health and social science databases, grey literature and reference/citation tracking. Three reviewers screened titles, abstracts and full texts of retrieved records, and extracted key data from included papers. Evidence was synthesised based on characteristics of research systems and quality-assessed for relevance, rigour and richness.

Findings:
Nine models were examined in depth. From these, we developed a typology of research systems. Few models were specifically designed for LA research activity; as a Whole System approach, the Local Authority Champions of Research model offers a potential blueprint. Useful lessons may be learned from UK Collaborations for Leadership in Applied Health Research, Academic Collaborative Centres in the Netherlands, local Research and Development units in Sweden, and generic University-Community partnerships.

Discussion and conclusions:
An optimal research system requires the coexistence of multiple systems including Centre, Partnership, Collaboration, Network and Community types. The review is UK-focused, but the models appear to have wider relevance. Our classification offers those planning an LA research system the opportunity to choose an approach that meets their requirements and resources. A Whole System approach is optimal, with egalitarian input from the LA and academia.
Geospatial based model for malaria risk prediction in Kilombero valley, South-eastern, Tanzania
Authors: Mwangungulu Stephen P. , Dorothea Deus , Ngereja Zakaria R. , Kaindoa Emmanuel W. 
Published: October 2023

Background
Malaria continues to pose a major public health challenge in tropical regions. Despite significant efforts to control malaria in Tanzania, there are still residual transmission cases. Unfortunately, little is known about where these residual malaria transmission cases occur and how they spread. In Tanzania for example, the transmission is heterogeneously distributed. In order to effectively control and prevent the spread of malaria, it is essential to understand the spatial distribution and transmission patterns of the disease. This study seeks to predict areas that are at high risk of malaria transmission so that intervention measures can be developed to accelerate malaria elimination efforts.

Methods
This study employs a geospatial based model to predict and map out malaria risk area in Kilombero Valley. Environmental factors related to malaria transmission were considered and assigned valuable weights in the Analytic Hierarchy Process (AHP), an online system using a pairwise comparison technique. The malaria hazard map was generated by a weighted overlay of the altitude, slope, curvature, aspect, rainfall distribution, and distance to streams in Geographic Information Systems (GIS). Finally, the risk map was created by overlaying components of malaria risk including hazards, elements at risk, and vulnerability.

Results
The study demonstrates that the majority of the study area falls under moderate risk level (61%), followed by the low risk level (31%), while the high malaria risk area covers a small area, which occupies only 8% of the total area.

Conclusion
The findings of this study are crucial for developing spatially targeted interventions against malaria transmission in residual transmission settings. Predicted areas prone to malaria risk provide information that will inform decision-makers and policymakers for proper planning, monitoring, and deployment of interventions.
The impact of COVID-19 on opioid toxicity deaths for people who experience incarceration compared to the general population in Ontario: A whole population data linkage study
Authors: Butler Amanda , Croxford Ruth , McLeod Katherine E. , Gomes Tara , Orkin Aaron M. , Bondy Susan J. , Kouyoumdjian Fiona G. 
Published: October 2023

Background
To inform preparedness and population health action, we need to understand the effects of COVID-19 on health inequities. In this study, we assess the impact of COVID-19 on opioid toxicity deaths among people who experience incarceration compared to others in the general population in Ontario, Canada.

Methods
We conducted a retrospective cohort study for the period of January 1, 2015 to December 31, 2020. We accessed and linked coronial data on all opioid toxicity deaths in Ontario with correctional data for people aged 18 years and older who were incarcerated in a provincial correctional facility. We used data from the Statistics Canada Census to calculate whole population rates. We used an interrupted time series design and segmented regression to assess for change in the level or rate of increase in deaths due to opioid toxicity coinciding with the COVID-19 pandemic. We compared the impact of COVID-19 on the opioid toxicity death rates for people exposed and not exposed to incarceration.

Results
Rates of opioid toxicity death increased with a linear positive slope in both persons exposed to incarceration and those not exposed over the study period. The start of COVID-19 measures coincided with a marked upward shift in the trend lines with modification of the effect of COVID-19 by both sex and exposure to incarceration. For persons exposed to incarceration, the risk ratio (RR) was 1.50 (95%CI 1.35–1.69) for males and 1.21 (95%CI 1.06–1.42) for females, and for persons not exposed to incarceration, the RR was 1.25 (95%CI 1.13–1.38) for males and not significant for females.

Conclusions
COVID-19 substantially exacerbated the risk of opioid toxicity death, impacting males and females who experienced incarceration more than those who had not, with an immediate stepwise increase in risk but no change in the rate of increase of risk over time. Public health work, including pandemic preparedness, should consider the specific needs and circumstances of people who experience incarceration.
ST-Segment Elevation Myocardial Infarction and Bleeding Complications in JAK2-Negative Polycythemia
Authors: Duran Luciano Priscilla , Sabella-Jiménez Vanessa 
Published: October 2023

Abstract
Thrombotic and bleeding complications are major causes of morbidity and mortality in patients with polycythemia vera, who predominantly present with an alteration in the JAK2 gene. Because of their hypercoagulable state and risk of hemorrhage, patients with polycythemia vera who present with an acute myocardial infarction pose a challenge to physicians. This case report describes the presentation and treatment of a Hispanic patient with JAK2 V617F–negative primary polycythemia who developed cardiac arrest and ST-segment elevation myocardial infarction owing to complete occlusion of the left anterior descending artery as well as bleeding complications and postmyocardial pericarditis.
Knockdown of SETD5 inhibited glycolysis and tumor growth in gastric cancer cells by down-regulating Akt signaling pathway
Authors: Shi Jing , Yu Litao , Zhu Changhong , Zhong Haiyan 
Published: October 2023

Abstract
Gastric cancer (GC) is the 5th most common cancer and the 3rd leading cause of cancer-related death worldwide. It is of great significance to study the underlying molecular mechanism of GC, and targeting glycolysis is a good strategy to treat GC. SET domain containing 5 (SETD5) contains a catalytic methyltransferase SET domain, which is known as a lysine methyltransferase that affects the progression of multiple cancers. However, its possible role in GC was still unclear. Here, we revealed that SETD5 was highly expressed in GC and was associated with a poor prognosis. Further through the in vitro experiments, we revealed that the downregulation of SETD5 inhibited the proliferation and migration of GC cells. Knockdown of SETD5 inhibited glucose consumption and glycolysis. Further studies have shown that SETD5 knockdown restrained the Akt signaling pathway. Therefore, we thought that SETD5 could act as a GC target.
On the localized and periodic solutions to the time-fractional Klein-Gordan equations: Optimal additive function method and new iterative method
Authors: Mukhtar Safyan , Abu Hammad Ma’mon , Shah Rasool , Alrowaily Albandari W. , Ismaeel Sherif M. E. , El-Tantawy Samir A. 
Published: October 2023

AbstractThis investigation explores two numerical approaches: the optimal auxiliary function method (OAFM) and the new iterative method (NIM). These techniques address the physical fractional-order Klein-Gordon equations (FOKGEs), a class of partial differential equations (PDEs) that model various physical phenomena in engineering and diverse plasma models. The OAFM is a recently introduced method capable of efficiently solving several nonlinear differential equations (DEs), whereas the NIM is a well-established method specifically designed for solving fractional DEs. Both approaches are utilized to analyze different variations in FOKGE. By conducting numerous numerical experiments on the FOKGE, we compare the accuracy, efficiency, and convergence of these two proposed methods. This study is expected to yield significant findings that will help researchers study various nonlinear phenomena in fluids and plasma physics.
ОСОБЕННОСТИ НАСТАВНИЧЕСТВА В КОНТЕКСТЕ СОВРЕМЕННЫХ УСЛОВИЙ ФУНКЦИОНИРОВАНИЯ И РАЗВИТИЯ СИСТЕМЫ ОБРАЗОВАНИЯ
Authors: Фомина Ольга Евгеньевна , Ростовская Тамара Керимовна 
Published: October 2023

Целью исследования является выявление возможностей и видов наставничества как метода профессиональной подготовки и студентов педагогического направления и профессионального становления молодых педагогов в процессе работы в образовательных организациях.
Методологическую базу исследования представляют положения диалектической теории о всеобщей связи, взаимообусловленности и целостности явлений, идеи дидактики и педагогической антропологии об обучении и воспитании личности, об образовании как педагогическом процессе трансляции культуры и профессионального становления молодого специалиста.
Результаты исследования. В ходе проведенного исследования и анализа имеющегося практического опыта высших учебных заведений России по организации процесса профессионального становления студентов старших курсов и выпускников выявлен потенциал наставничества как одного из системообразующих факторов в профессиональном становлении молодого педагога. В работе раскрыты виды и формы наставничества как современного подхода к работе с молодыми специалистами, направленного на профессиональное становление молодых педагогов, помощь в формировании индивидуального стиля педагогической деятельности, реализации творческого потенциала будущего педагога, а также феномен самореализации наставника и взаимодействие представителей разных поколений в педагогической деятельности.
Перспективы исследования заключаются в разработке дидактического обеспечения процесса профессионального становления молодого педагога в модели «наставник — наставляемый» в образовательном пространстве университета.
ВЗАИМОДЕЙСТВИЕ УЧАСТНИКОВ ОБРАЗОВАТЕЛЬНОГО ПРОЦЕССА В ШКОЛАХ С НИЗКИМИ УЧЕБНЫМИ РЕЗУЛЬТАТАМИ: СОЦИОЛОГИЧЕСКИЙ АНАЛИЗ
Authors: Баранова Наталья Сергеевна , Истомина Ольга Борисовна 
Published: October 2023

Целью исследования является анализ взаимодействия педагогических работников и родителей (законных представителей) обучающихся школ с низкими образовательными результатами.
Методологическую основу исследования составляют положения трудов российских и зарубежных ученых, посвященных рассмотрению проблем вовлечения родителей в образовательный процесс, проектированию взаимодействия школы и семьи на современном этапе, влиянию коммуникации педагогов и родителей на академические результаты школьников. Привлечены данные федеральных, региональных статистических исследований об удовлетворенности родителей образовательными системами и результаты проведенных опросов акторов образовательного процесса школ с низкими образовательными результатами. Применены общелогические и теоретические методы исследования (анализ, синтез, сравнение), а также методы эмпирического исследования (вторичный анализ статистических данных, анкетирование, описание).
Результаты исследования. На основе анализа федеральных и региональных статистических данных об уровне удовлетворенности родителей сложившейся системой образования и результатов эмпирического исследования авторы определяют особенности взаимодействия школы и семьи обучающегося. Особое внимание уделено сравнению позиций педагогов и родителей детей из школ с низкими результатами обучения Иркутской области. Критерий сравнения — территориальная принадлежность (город/село). Делается вывод о возможных «барьерах» развития партнерских отношений педагогов и родителей в вопросах повышения образовательных результатов, воспитания и общекультурного развития школьников.
Перспективы результатов исследования видятся в их применении в реальной практике корректирующей программы обучения и воспитания с целью минимизации негативных факторов влияния на региональную и муниципальную системы образования. Материалы исследования будут полезны практикам административно-управленческого аппарата в проектировании социально-экономических, социокультурных компонентов программ повышения качества образования за счет повышения вовлеченности родителей в образовательный процесс на уровне общеобразовательной организации, муниципалитета и региона.
СИСТЕМАТИЗАЦИЯ СОЦИАЛЬНО-УПРАВЛЕНЧЕСКИХ ПОДХОДОВ К ПРЕОДОЛЕНИЮ СТАГНАЦИИ В ПРОЦЕССАХ ИННОВАЦИЙ
Authors: Воронцов Алексей Васильевич , Шелонаев Сергей Игоревич , Цыплакова Ольга Геннадьевна 
Published: October 2023

Целью исследования является изучение влияния цифровой трансформации как относительно нового явления на управление организацией, поскольку социология управления уже более полувека изучает вопросы организационного развития как целостного и непрерывного процесса, включая преодоление препятствий и проблематику саботажа организационных изменений. В 2016–2021 годах вышел ряд «гайдов» руководств крупных глобальных агентств по анализу факторов, определяющих неудачи проектов цифровой трансформации в крупных корпорациях, но эти отчёты и руководства отражают разрозненные наработанные практические приёмы.
Методологическую базу исследования представляют базисные положения теории организаций. К используемым научным методам относятся сравнительно-исторический, причинно-следственный и системный анализ.
Результаты исследования. Предпринята попытка сгруппировать предлагаемые приёмы и инструменты и систематизировать их в соответствии с факторами, выступающими причиной неудач или инструментами решения проблематики сопротивления организационным инновационным процессам. В качестве примера рассматривается цифровая трансформация современных компаний, особенности ее проведения и причины неудач, проводится теоретический анализ исследований и практических кейсов корпоративных проектов цифровой трансформации. Выявляются структурные, институционально-ценностные и процессные аспекты, которые играют решающую роль в успешности проводимых организационных изменениях в компании. Особое внимание уделяется рискам, возникающим в процессе цифровой трансформации, методам стимулирования и мотивирования персонала, в особенности обучению сотрудников. В качестве результатов исследования авторами представлены социально-управленческие подходы к преодолению стагнации при проведении организационных инноваций.
Перспективы исследования. Современным компаниям, планирующим цифровую трансформацию, стоит уделить внимание социально-управленческим подходам, которые помогут преодолеть сложности при проведении организационных инноваций. Разработанная авторами систематизация подходов представляет не только теоретический интерес, но также будет полезна топ-менеджерам компаний при проведении цифровой трансформации.
Artificial intelligence application in auditing
Authors: Ivakhnenkov Serhii 
Published: October 2023

Artificial intelligence (AI) is a rapidly evolving technology that has gained prominence in various industries, including auditing. AI enhances the effectiveness of auditors by automating routine tasks and improving data analysis. Major audit companies, such as EY and PwC, have integrated AI into their practices to save time, increase accuracy, and provide better services to clients. AI applications in auditing include anomaly detection, fraud prevention, revenue analysis, risk assessment, and financial data analysis. Machine learning algorithms, a subset of AI, play a crucial role in analyzing large volumes of financial data, identifying patterns, and making predictions.AI implementation in auditing involves different stages, including pre-planning, planning, contracting, control risk assessment, and substantive tests. The benefits of AI for auditors and clients include improved data analysis, reduced human error, increased efficiency, and enhanced audit quality. However, the successful implementation of AI in auditing requires a clear understanding of its strengths, limitations, and challenges, as well as interdisciplinary collaboration and the development of specialized frameworks.AI has the potential to transform audit procedures, but human expertise and understanding are still essential for its proper use. It is important to recognize that while AI can automate certain tasks, it cannot replace auditors’ judgment and critical thinking skills.There are also challenges associated with AI implementation in auditing. These include the need for extensive data preparation, ensuring data quality and integrity, managing complex algorithms, and addressing regulatory and compliance issues. Furthermore, auditors must stay updated with the latest advancements in AI and continuously adapt their skills to leverage the technology effectively.
JEL classification: M420
La recuperación de las preocupaciones estructurales. La sentencia Towercast y la vuelta de Continental Can
Authors: Herrero Suárez Carmen 
Published: October 2023

El TJUE ha reconocido recientemente la aplicabilidad a una operación de concentración ya realizada de las normas que sancionan el abuso de posición dominante. Esta sentencia no es un fenómeno aislado ni su trascendencia se limita al campo del control de la concentración empresarial, sino que, como será objeto de análisis en este trabajo, constituye una manifestación más del cambio de sentido que está experimentando en los últimos años la política antitrust y cuyo alcance aún está siendo objeto de definición.
El nuevo juicio verbal previsto en el proyecto de ley de medidas de eficiencia procesal del servicio público de Justicia y los estándares europeos
Authors: Sigüenza López Julio 
Published: October 2023

Si el proyecto de ley de medidas de eficiencia procesal del servicio público de Justicia resulta finalmente aprobado tal y como fue remitido en su día a las Cortes Generales, la configuración actual del juicio verbal mudará sustancialmente, ya que dejará de tener una tramitación rápida y sencilla, pudiendo llegar a desarrollarse íntegramente por escrito, contrariamente a lo que su propia denominación sugiere.
La propuesta parece estar inspirada en la normativa que regula diversos procesos europeos. Sin embargo, se aleja de los estándares que inspiran la regulación de juicios similares en Alemania, Francia, Portugal y otros países de la “zona euro”, lo que, en nuestra opinión, debería hacer recapacitar a nuestras autoridades sobre la conveniencia y oportunidad de dicha reforma.