bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Methotrexate in Psoriasis Vulgaris Long-Term Treatment: A Real-World Observation Study
Authors: Wilsmann-Theis Dagmar , Funk Rhena , Mössner Rotraut , Bieber Thomas , Wenzel Jörg 
Published: January 2024

Abstract

Background:
Methotrexate (MTX) in the therapy of psoriasis vulgaris (PV) is a well and long-established treatment option.

Aims:
To assess the long-term experience of individual patients in the real world with regard to the efficacy and safety of MTX in PV therapy.

Patients and Methods:
In a retrospective study, MTX as a weekly used monotherapy in PV was examined. Clinical data including the Psoriasis Area Severity Index (PASI), prevalence of psoriatic-arthritis (PsA), Investigator Global Assessment (IGA), laboratory parameters, occurrence of adverse events (AEs), dosing of MTX and characteristics of patients treated for at least 24 months were collected.

Results:
A total of 55 patients with 247 patient-years under MTX therapy were included. The mean PASI reduction was 51.2% with a significant (P < 0.001) improvement in the skin condition in the first 6 months of treatment, remaining stable thereafter. The mean MTX dose increased from 11.8 ± 3.7 mg to 12.9 ± 3.8 mg in the first year of therapy, with a constant mean dose in the following years. In 247 patient-years, no serious AE was documented. Gastrointestinal side effects or fatigue were commonly detected. The liver parameter alanine aminotransferase/ glutamate-pyruvate transaminase (ALT/GPT) (baseline 35.8 ± 22.0 U/L) increased after 3 years of therapy (42.0 ± 22.4 U/L; P = 0.013) without clinical significance.

Conclusion:
In this patient collective, MTX in low doses was effective and safe in long-term therapy. The improved skin condition was steady and reached by an unvarying dose. New data showed a better efficacy of MTX in higher doses; however, additional data must be collected on the long-term efficacy and safety of MTX with a higher dose regime.
SARS-CoV-19 and Generalised Pustular Psoriasis: A Lethal Combination
Authors: Narang Tarun , Sharma Apoorva , Bhandari Adhyatm , Handa Sanjeev , Dogra Sunil 
Published: January 2024

Abstract
Generalised pustular psoriasis(GPP) is a rare, potentially life-threatening variant of psoriasis with acute onset, widely spread pustular lesions on an inflamed base associated with a systemic inflammatory state. In the setting of the current COVID-19 pandemic, flares in pustular psoriasis have been reported, however these flares leading to mortality in SARS-CoV-2 infected patients is hitherto unreported. We present two cases of GPP flare following SARS-CoV-2 infection with fatal outcome. A 20 year old male, known case of GPP since 5 years presented with an exacerbation of his existing disease for 2 months. He had received methotrexate, cyclosporine, acitretin, apremilast, infliximab and secukinumab in the past. He was admitted and started on inj. methotrexate (subcutaneous) and cap. acitretin. During admission, he developed COVID-19 associated severe acute respiratory distress syndrome(ARDS). Despite timely intervention with life-saving measures, the patient could not be saved. The second case was a 52-year-old female, a case of GPP on treatment for the last 10 years, being maintained on cap. acitretin and cyclosporine. She also developed ARDS due to COVID infection. Despite being on acitretin for GPP and the appropriate management of severe COVID infection, her condition worsened and she expired within one day of admission. Both of our patients were not vaccinated against COVID-19. Awareness of potential risk of mortality in patients of GPP getting co-infected by COVID-19 is thus essential for dermatologists.
Designing and validating a research questionnaire - Part 2
Authors: Ranganathan Priya , Caduff Carlo , Frampton Christopher M. A. 
Published: January 2024

Abstract
Validity and reliability refer to the accuracy and consistency of a research tool. In the previous article in this series, we examined the development of a research questionnaire. In this article, we discuss the methods of determining the validity and reliability of a research questionnaire.
Effects of therapeutic patient education program on glycemic control and quality of life among children and adolescents with type 1 diabetes mellitus in Fez city, Morocco
Authors: Ait-Taleb Lahsen Hanaâ , Ragala Mohammed El Amine , El Abed Hanane , Zarrouq Btissame , Halim Karima 
Published: January 2024

Abstract

Context:
Type 1 diabetes mellitus (T1DM) is a chronic disease, mainly observed in children or youth, with a significantly increased incidence in young children. Structured therapeutic patient education (TPE) is a must to help them manage their disease effectively and lead a healthy lifestyle.

Aims:
This study aimed to assess the effects of a structured TPE program on glycemic markers and quality of life (QOL) of T1DM children and adolescents in Fez city, Morocco.

Settings and Design:
It is a quasi-experimental study.

Materials and Methods:
One hundred T1DM children and adolescents, aged 8–18, participated in a TPE intervention at the pediatric department in a hospital center in Fez, Morocco. Glycemic markers were measured and QOL was assessed by a validated questionnaire.

Statistical Analysis Used:
Parametric and nonparametric tests were used and statistical significance determined by P < 0.05.

Results:
At 3 months’ follow-up, both global and dimensional QOL mean scores improved significantly (P ≤ 0.0001), whereas glycosylated hemoglobin (HbA1c) decreased (10.28% vs. 10.62%), tough with no statistical significance (P = 0.160). Furthermore, a significant improvement was observed in the maximum preprandial (2, 11 g/L [1.51–2.58] vs. 2, 37 g/L [1.81–3.21], P = 0.001) and postprandial blood glucose levels (2, 50 g/L [1.90–3.27] vs. 2, 95 g/L [2.07–3.99], P = 0.001) after 3 months; with no significant change in their minimum.

Conclusion:
Although this TPE intervention was more effective in improving patients’ QOL than their HbA1c, it is worth striving to implement regular TPE programs for T1DM pediatric patients and adjust them to achieve a better patients’ glycemic markers levels.
How to determine a curve singularity
Authors: Elias J. 
Published: January 2024

AbstractWe characterize the finite codimension sub-
${\mathbf {k}}$
-algebras of
${\mathbf {k}}[\![t]\!]$
as the solutions of a computable finite family of higher differential operators. For this end, we establish a duality between such a sub-algebras and the finite codimension
${\mathbf {k}}$
-vector spaces of
${\mathbf {k}}[u]$
, this ring acts on
${\mathbf {k}}[\![t]\!]$
by differentiation.
Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report
Authors: Gramaça João , Fernandes Isabel Gomes , Trabulo Carolina , Gonçalves Joana , dos Santos Rita Gameiro , Baptista Adriano , Pina Idília 
Published: January 2024

BACKGROUND
In patients with metastatic colorectal cancer (mCRC), the treatment options are limited and have been proved to be affected by rat sarcoma virus (RAS) mutational status. In RAS wild-type (wt) patients, the combination of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies with chemotherapy (CT) is more effective than CT alone. On the other hand, RAS-mutated patients are not eligible for treatment with anti-EGFR antibodies.
CASE SUMMARY
Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May 2022. At the time of cell-free DNA determination, five patients had undergone one CT line, five patients had undergone two CT lines, and one patient had undergone three CT lines (all in combination with bevacizumab). At the second and third treatment lines [second line (2L), third line (3L)], patients with neo-RAS wt received a combination of CT and cetuximab. In neo-RAS wt patients treated with anti-EGFR, our findings indicated an increase in progression-free survival for both 2L and 3L (14.5 mo, P = 0.119 and 3.9 mo, P = 0.882, respectively). Regarding 2L overall survival, we registered a slight increase in neo-RAS wt patients treated with anti-EGFR (33.6 mo vs 32.4 mo, P = 0.385). At data cut-off, two patients were still alive: A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR (ongoing).
CONCLUSION
Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.
The role of pediatric neurosurgery in the Sustainable Development Goals
Authors: De Oliveira Ricardo , Ballestero Matheus 
Published: January 2024

The Sustainable Development Goals (SDGs) are a set of 17 interconnected global goals adopted by all United Nations (UN) Member States in 2015 to end poverty, reduce inequality and build more peaceful, prosperous societies by 2030 [1] (Figure.1).
The SDGs aim to leave no one behind and promote peace, prosperity, and the protection of the planet [2].
Pediatric neurosurgery intersects with several of these goals, contributing to the overall improvement of health, well-being, and social and economic development. Here are some ways in which pediatric neurosurgery aligns with the SDGs:
PEMBINAAN KREATIFITAS IKATAN REMAJA MESJID AL-MUHTADUN DENGAN MELAKUKAN PELATIHAN PEMBUATAN BRUS DAGU
Authors: LUBIS RENIWATI 
Published: January 2024

Keterampilan masyarakat saat ini masih dikatakan minim. Masih ada masyarakatÂ yang saat ini memiliki keterampilan yang sedikit. Keterampilan perlu ditambah dan ditingkatkan agar menghasilkan sumber daya manusia yang terampil.. Keterampilan harus dibarengi dengan kreatifitas, tanpa kreatifitas hidup kurang memiliki seni. Maka dari itu, melalui program pengabdian masyarakat ini, Tim pengabdian masyarakat berkerjasama dengan Ikatan Remaja Mesjid Al-Muhtadun untuk melaksanakan pelatihan membuat bros dagu di Kecamatan Medan Selayang agar Ikatan Remaja Mesjid Al-Muhtadun dan masyarakat yang tinggal disekitar mesjid Al-Muhtadun yang belum mampu melaksanakan pembuatan bros dagu dapat membuat bros dagu untuk menambah minimal pendapatan untuk diri sendiri. Progaram pelatihan pembuatan bros daguini dilaksanakan denganÂ 3 tahapan, yaitu: (1) tahap persiapan, (2) tahap pelaksanaan dan (3) tahap penutupUntuk materi yang akan diberikan dengan 3 tahap, yaitu:Â tahap pertama merupakanÂ tahap dasar, yang kedua tahap lanjutan dan yang ketiga tahap terampil. Pelaksanaan pelatihan ini dilaksanakan selama 4 (empat) hari. Dimana setiap tingkatan tahap dilaksanakan per hari dan pada hari keÂ empat dilaksanakan tes. Tes ini dilakukan untuk mengetahui sejauhmana pemahaman pembuatan bros dagu. Hasil dari program pengabdian ini peserta mampu membuat bros dagu.
Penerapan Algoritma Entropy Dan Aras Menentukan Penerima Beasiswa Mahasiswa Berprestasi Di Pemerintah Kabupaten Labuhanbatu
Authors: Ernawati Andi 
Published: January 2024

In handling scholarship data for outstanding students, the Labuhanbatu Regency government in general still uses manual recording, namely by using a ledger and there is no computerization in determining the receipt of scholarships for outstanding students, so there are many mistakes in determining it.
The problem faced by the many recipients of scholarships for outstanding students who are not appropriate so that those who deserve to receive do not receive and those who do not deserve to receive scholarships. This problem occurs because of the difficulty in implementing the selection of scholarship recipients due to the large number of applicants and the number of the same criteria in receiving scholarships. So that mistakes often occur To apply for a scholarship at the People's Welfare Office in the Labuhanbatu Regency government, students must fill out a form containing data from the student, such as Grade Point Average (GPA), Parents' income, Number of Siblings, Number of Dependent Parents. The ranking process in receiving scholarships uses the Entropy Method in giving weighting to the criteria objectively and the ARAS Method, which is a suitable method in determining the calculation of weights based on predetermined criteria and ranking from a set of alternative data that kick each other. So that it can reduce the errors that have been faced so far.
Pengembangan Media Video Pembelajaran Untuk Mengembangkan Kemampuan Berpikir Simbolik Pada Anak Usia 5-6 Tahun
Authors: Vista Banggur Maria Dissriany , Tamo Ina Talu Adriani , Esabella Shinta , Rodianto  
Published: January 2024

This study aims to develop the symbolic thinking skills of children aged 5-6 years in Santa Clara Ka Redong Kindergarten using learning video media. This type of research is development research using the ADDIE Model. The ADDIE model consists of several components, namely: analysis, design, develop, implementation and evaluation. The results of the study stated that the use of learning video media can help children aged 5-6 years to develop symbolic thinking skills consisting of: children are able to mention symbols of numbers 1-10, children are able to show symbols of numbers 1-10, children are able to mention symbols of numbers 1-10 sequentially, children are able to use number symbols in counting many images, children are able to use number symbols in summing images, Children are able to use number symbols in subtracting images, Children are able to mention the number of images according to the number symbol, Children are able to show the number of images according to the number symbol, Children are able to match the number of images according to the number symbol, Children are able to mention vowels and consonants, Children are able to mention the number of letters of vowels and consonants, Children are able to name objects, Children are able to represent objects in the form of pictures, The child can represent objects in written form
Implementasi Algoritma Metode Naive Bayes dan Support Vector Machine Tentang Pembobolan dan Kebocoran Data di Twitter
Authors: Zy Ahmad , Wahyu Hadikristanto  
Published: January 2024

Abstrak− Data breaches dan data leakage merupakan masalah yang semakin meningkat dalam dunia teknologi saat ini. Ada banyak diskusi yang terjadi di media sosial, terutama di Twitter, mengenai masalah ini. Dalam paper ini, kami menggunakan analisis sentimen untuk mengevaluasi persepsi publik terhadap masalah keamanan data dan kebocoran data di Twitter. Kami menggunakan algoritma Support Vector Machine (SVM) dan Naïve Bayes untuk melakukan klasifikasi sentimen pada teks yang diambil dari Twitter. Hasil dari penelitian ini akan memberikan gambaran yang lebih baik mengenai persepsi publik terhadap masalah keamanan data dan kebocoran data dan dapat digunakan oleh pihak yang berkepentingan untuk meningkatkan keamanan data Selanjutnya, paper ini akan mendeskripsikan metodologi yang digunakan dalam pengumpulan data dari Twitter, proses pre-processing data, dan implementasi algoritma SVM serta Naïve Bayes untuk melakukan klasifikasi sentimen. Kemudian, hasil dari analisis sentimen akan dianalisis dan dibahas secara mendalam, serta dibandingkan dengan hasil analisis sentimen yang dilakukan dengan metode lain. Pada paper ini didapatkan hasil perhitungan algorithma NaïveBayes dengan precision 97%, dan perhitungan dari algorithma SVM didapatkan hasil Precision sebesar 80%.Selain itu, paper ini juga akan mencakup kesimpulan dan saran untuk penelitian selanjutnya dalam bidang yang sama.
Kata Kunci: Data breaches, Data leakage, Teknologi, Media Sosial, Twitter, Analisis sentimen
Sistem Pendukung Keputusan Kelayakan Pemberian Kredit Nasabah Dengan Metode Electre
Authors: Lasena Marlin , Ahmad Sulistiawati Rahayu 
Published: January 2024

PT Hasjrat Abadi has collaborated with a financing institution to provide opportunities for vehicle ownership through credit facilities. The credit system offered by the financing institution can boost vehicle sales. However, before that, the lender must conduct a thorough consumer data analysis. This is crucial to ensure that potential customers can repay the approved vehicle loans, thereby avoiding the risk of loan defaults in the future. The process of consumer data analysis is time-consuming due to the abundance of documents involved. Additionally, field surveys are necessary to validate consumer data by applying the 5C Bank Principles (character, capital, capacity, collateral, and condition).
Research Objective By implementing the Electre (Elimination and Choice Translation Reality) method in the decision support system, we can provide quick, accurate, and precise information to determine whether potential customers are eligible to purchase vehicles from PT Hasjrat Abadi through credit. This method utilizes the 5C Bank Principles (character, capital, capacity, collateral, and condition) to evaluate consumers. The method used is Research and Development (R&D), which aims to develop specific products and test their effectiveness.
The research findings indicate that this system can enhance the services provided to customers at PT Hasjrat Abadi's branch in Gorontalo. Based on the data input by credit analysts, it was found that only 50 percent of the total potential customer data could be approved using the Electre method for credit applications. This facilitates faster, more accurate, and more reliable decision-making for customers.
Implementasi Sistem Pakar Diagnosis Autisme Pada Anak Menggunakan Metode Naïve Bayes
Authors: Husna Syah Zanul , Putri Raissa Amanda 
Published: January 2024

Autism is a developmental disorder that affects the normal functioning of the brain, thereby affecting a child's communication and social interaction abilities. This disorder poses a problem for children in communicating and forming relationships with their environment. As the number of individuals with autism increases, public awareness of autism remains very low. Additionally, most psychologists or psychiatrists are located in major cities, limiting access for rural communities. This leads to many parents struggling to obtain information about autism symptoms. The research method used is the naïve Bayes method, it can be drawn from the system is that it will generate the maximum score despite any disturbances in the provided data. The results of this research align with expert knowledge, suggesting that it can be relied upon to accurately diagnose autism based on the symptoms experienced by individuals. The aim of this study is to build an expert system that can provide information and solutions to parents regarding autism disorders based on their knowledge of the symptoms they experience, enabling users to diagnose autism in their children early on without incurring costs.
Objeción de conciencia al aborto: comentario a la sentencia del Tribunal Constitucional 44/2023, de 9 de mayo de 2023
Authors: ZALDIBIA LUENGO PABLO 
Published: January 2024

El Tribunal Constitucional en sentencia 44/2023, de 9 de mayo de
2023 ha realizado un control de constitucionalidad de las restricciones de la objeción
de conciencia al aborto establecidas en el art. 19.2 de la Ley Orgánica 2/2010
de salud sexual y reproductiva y de la interrupción voluntaria del embarazo. El
presente artículo realiza un examen analítico y crítico del dictamen recurriendo
al principio de proporcionalidad. El autor difiere del pronunciamiento del Tribunal
Constitucional sobre la categoría legal asignada a la objeción de conciencia por
vulnerar los artículos 1.1, 14, 16.1 y 16.3 de la Constitución. No obstante, comparte
el juicio de principio de proporcionalidad que, sobre las restricciones, efectúa el
Tribunal Constitucional, con la discrepancia parcial de que la objeción de conciencia
debe extenderse también a los deberes jurídicos médicos que componen la
fase preparatoria, así como el referido a la recogida y destrucción final de los restos
fetales.
Konstituzio Auzitegiak, 2023ko maiatzaren 9ko 44/2023 epaian,
Sexu- eta ugalketa-osasunari eta haurdunaldia borondatez eteteari buruzko 2/2010
Lege Organikoaren 19.2. artikuluan abortuaren kontzientzia-eragozpenari ezartzen
zaizkion murrizketen konstituzio-kontrola egin du. Ondorengo artikuluak, sententzia
horren azterketa kritiko eta analitiko bat egiten du, proportzionaltasun-printzipiora
joz. Egilea ez dator bat Konstituzio Auzitegiak kontzientzia-eragozpenari ezarritako kategoria
juridikoarekin, Konstituzioaren 1.1, 14, 16.1 eta 16.3 artikuluak urratzeagatik.
Hala ere, ados dago Konstituzio Auzitegiak murrizketen inguruan egiten duen proportzionaltasun-
printzipioaren judizioarekin, desadostasun partzial bat salbuetsita, hots:
kontzientzia-
eragozpena prestatze-fasea osatzen duten legezko betebehar medikoetara
ere zabaldu behar da, baita fetu-hondarrak bildu eta suntsitzeari buruzkoetara ere.
The Spanish Constitutional Court in 44/2023 judgment of May
9th, 2023 conducted a constitutionality review of the restrictions on conscientious
objection to abortion as established in article 19.2 of Organic Law 2/2010 on sexual
and reproductive health and voluntary termination of pregnancy. This paper
carries out an analytical and critical examination of the ruling by using principle
of proportionality. The author differs from the Constitutional Court¿s decision as far
as the legal category assigned to conscientious objection for violating articles 1.1,
14, 16.1 and 16.3 of the Constitution. However, he shares the Constitutional Court¿s
reasoning on the principle of proportionality regarding the restrictions, with the
partial discrepancy that conscientious objection should also extend to the medical
legal duties that make up the preparatory phase, as well as the one referring to the
collection and final destruction of foetal remains.
Alguns comentários acerca de um caso relatado por Wade e Rodrigues nos anos 30
Authors: OPROMOLLA Diltor V. A. 
Published: January 2024

Wade e Rodrigues relataram um caso de hansen lase que foi seguido durante um período de 8 anos (1932-1940). Inicialmente o paciente foi considerado ser portador de uma forma tuberculoide minor, que evoluiu rapidamente e se transformou em uma forma tuberculoide major. Após um período de quase 2 anos sem manifestação da doença, ele apresentou novos e mais graves episódios reacionais que mais tarde se tomaram bolhosos. O caso foi considerado "Borderline" pela evolução característica das lesões e resultado da baciloscopia. O autor considerou este caso como um caso reacional desde o início e comentou também seus aspectos evolutivos, clínicos e bacteriológicos. Ele chamou a atenção para regressão das lesões e o desaparecimento dos bacilos sem influência da terapêutica e mais tarde ocorrência de novos surtos e reaparecimento de bacilos, mesmo após um longo período de tempo. Este relato permitiu elaborar uma hipótese na qual os bacilos em casos "Borderline" reacionais desaparecem na sua major parte devido à ação do sistema imune do hospedeiro diferente dos casos tuberculoides reacionais nos quais há uma destruição total dos bacilos, e por isso os novos surtos são causados pormultiplicação de bacilos persistentes. A confirmação desta hipótese poderia ter implicações terapêuticas. A PQT/OMS seria incapaz de evitar novos episódios reacionais quando a multiplicação bacteriana ocorrer fora do período da atividade da droga. Se isso for assim a reação reversa que ocorre após o tratamento poderia realmente ser uma recidiva e a melhor opção para o tratamento seria dar as drogas todos os dias, ou em intervalos curtos até o aparecimento de um episódio agudo. O autor também enfatiza quanto nsinamento pode ser adquirido com o estudo dos casos bem documentados relatados pelos antigos pesquisadores.