bluuebunny/crossref_metadata_2025_split huggingface dataset:
Popliteal Artery Aneurysms
Authors: Davidovic Lazar B. , Lotina Slobodan I. , Kostic Dusan M. , Cinara Ilijas S. , Cvetkovic Slobodan D. , Markovic Dragan M. , Vojnovic Bojan R. 
Published: August 2002

AbstractAltogether 59 patients with 76 popliteal artery aneurysms were treated during the last 36 years. There were 50 (85%) male and 9 (15%) female patients with an average age of 61 years. Nineteen (32%) patients had bilateral aneurysms. The clinical manifestations of the aneurysms included ruptures 4 (5.3%); deep venous thrombosis 4 (5.3%); sciatic nerve compression 1 (1.3%); leg ischemia 52 (68.4%), and asymptomatic pulsatile masses 15 (19.7%). Seventy (92%) aneurysms were atherosclerotic, one (1.3%) mycotic, and four (5.3%) traumatic; one (1.3%) developed owing to fibromuscular displasia. Seven (9.2%) small, asymptomatic aneurysms were not operated on. Reconstructive procedures (end‐to‐end anastomosis, graft interposition, bypass) after aneurysmal resection or exclusion using a medial or posterior approach were done in 59 cases. An autologous saphenous vein graft was used in 49 cases, polytetrafluoroethylene (PTFE) in 5, and heterograft in 2 cases. The in‐hospital mortality rate was 2.9%, the early patency rate 93.3%, and limb salvage 95%. The long‐term patency rate after a mean follow‐up of 4 years was 78% and long‐term limb salvage 89%. The total limb salvage was 73%, and the total amputation rate was 27%. The dangerous complications associated with popliteal artery aneurysms and the good results after elective procedures suggest that operative treatment is appropriate.
Cardiac Abnormalities Associated with Morbid Obesity
Authors: Herrera Miguel F. , Oseguera Jorge , Gamino Rosa , Gutiérrez‐Cirlos Carlos , Vargas‐Vorackova Florencia , González‐Barranco Jorge , Rull Juan A. 
Published: August 2002

AbstractMorbidly obese patients are at increased risk for structural and functional abnormalities of the heart. This paper summarizes the effects of obesity on the heart, the effect of weight reduction on cardiac function, the impact of coronary artery disease on cardiac cardiomyopathy, and our experience in obesity heart disease at the Instituto Nacional de la Nutrición in Mexico.
Microsomal Cytochrome P‐450 Monooxygenase System and Its Drug‐metabolizing Activity after Partial Portal Vein Ligation in the Rat
Authors: Izuishi Kunihiko , Wakabayashi Hisao , Kokudo Yasutaka , Maeba Takashi , Ryu Munemasa , Maeta Hajime 
Published: August 2002

AbstractPercutaneous transhepatic portal vein embolization (PTPE) has been used to decrease the risk of hepatic failure after hepatectomy in patients with poor liver function. The effect of PTPE on hepatic drug‐metabolizing activities is not clear. Therefore we examined the effect of portal vein branch ligation, a model of PTPE, on hepatic drug‐metabolizing activities in Sprague‐Dawley rats. Ligated and nonligated lobes were harvested separately. Drug‐metabolizing activities and concentrations of components of the microsomal cytochrome P‐450 monooxygenase system were examined. In ligated lobes, drug‐metabolizing activities (lidocaine and aminopyrine) and enzymatic concentrations of the microsomal cytochrome P‐450 monooxygenase system gradually decreased over 10 days. In nonligated lobes these functions were depressed rapidly to 60% of those before PBL but then recovered 10 days after PBL. From the viewpoint of drug metabolism, hepatic dysfunction occurred in both ligated and nonligated lobes.
Contribution of the Renal Medulla to Enhanced Ketogenesis with Ringer's Acetate Administration during Hepatic Inflow Occlusion RID="" ID="" This International Society of Surgery (ISS)/Soci&eacute;t&eacute; Internationale de Chirurgie (SIC) article was presented at the 37th World Congress of Surgery International Surgical Week (ISW97), Acapulco, Mexico, August 24&ndash;30, 1997.
Authors: Nakatani Toshio , Sakamoto Yoshimasa , Ando Hirofumi , Kobayashi Kunio 
Published: August 2002

AbstractWe have reported that the administration of Ringer's acetate solution (AR) maintains plasma ketone body concentrations even during hepatic ischemia due to enhanced ketogenesis in the kidney. In this study we tried to clarify which part of the kidney, cortex or medulla, contributes to the enhanced ketogenesis. During 20 minutes of hepatic inflow occlusion, AR or Ringer's lactate solution (LR) was administered. Ketone body concentrations in arterial and renal venous blood and renal cortical and medullary tissue were measured enzymatically. Results are expressed as means ± SEM. At
20 minutes of hepatic inflow occlusion, arterial ketone body concentrations decreased to 38% of preischemic values with the LR infusion but increased under AR administration and were four times higher than that with LR. The renal arteriovenous difference in ketone body concentration was 16 ± 14 μmol/ml before hepatic inflow occlusion and −52 ± 14 with AR administration, indicating that renal ketogenesis occurred during hepatic ischemia. Total ketone body concentrations in the renal cortex and medulla were 56 ± 6 and
61 ± 5 μmol/g, respectively with LR, but increased to 186
± 29 and 248 ± 25 μmol/g, respectively during AR administration. The concentration in the medulla was higher
(p= 0.12) than that in the cortex but did not reach statistical difference. Renal ketogenesis increases during hepatic inflow occlusion with AR administration. It is likely that the enhancement of ketogenesis takes place predominantly in the medulla of the kidney.RID="" ID="" <E5>Correspondence to:</E5> T. Nakatani, M.D., Department of Emergency and Critical Care Medicine, Kansai Medical University, 10‐15 Fumizonocho, Moriguchi, Osaka 570‐8507, Japan
Tumors of the Appendix and Colon
Authors: Hatch Kathryn F. , Blanchard D. Kay , Hatch George F. , Wertheimer‐Hatch Laura , Davis Gregory B. , Foster Roger S. , Skandalakis John E. 
Published: August 2002

Abstract.This collective review includes all available case reports of smooth muscle (stromal) tumors of the appendix and large intestine in the world literature. When compiling this review, we endeavored to examine cumulative as well as recently collected data on both benign and malignant smooth muscle tumors spanning the period 1875 to 1996. In total, there were reports of 331 leiomyomas (LMs) and 263 leiomyosarcomas (LMSs). The peak age of incidence of LM was 30 to 39 years, and the peak age of incidence of LMSs was 50 to 59 years. The female/male ratio was slightly higher for LM, and the male/female ratio was higher for LMS. The descending colon and sigmoid colon were the most common sites of both benign and malignant smooth muscle tumors. The growth of LMs most often occurred extraluminally, whereas LMSs tended to grow within the lumen of the colon. With both tumor types pain was the most frequent presenting complaint, followed less commonly by complaints of a palpable mass or gastrointestinal bleeding. LMSs tended to be larger at diagnosis than LMs, though the duration of symptoms for both types of tumor was most often reported to be between 1 month and 1 year. Finally, LMSs were found to metastasize most commonly to the liver, with metastatic disease reported in 43% of all cases.
Does Hyperthermia Induce Peritoneal Damage in Continuous Hyperthermic Peritoneal Perfusion?
Authors: Shido Akemi , Ohmura Shigeo , Yamamoto Ken , Kobayashi Tsutomu , Fujimura Takashi , Yonemura Yutaka 
Published: August 2002

Abstract.To investigate the mechanisms of the peritoneal damage induced by continuous hyperthermic peritoneal perfusion (CHPP), protein and fluid loss during and after CHPP and continuous normothermic peritoneal perfusion (CNPP) was studied. Sixteen patients with advanced gastric cancer underwent peritoneal perfusion therapy with saline solution containing 150 to 300 mg cisplatin and 30 to 60 mg mitomycin C for 60 minutes. The temperature in Douglas' pouch was maintained at 42.0°C in the CHPP group (n= 9) and 37.0°C in the CNPP group (n= 7) during perfusion. No statistical differences were found in patients' characteristics between the groups except the maximum temperature in Douglas' pouch during perfusion (41.6°± 0.4°C and 37.6°± 0.4°C in CHPP and CNPP groups, respectively, p < 0.05). The amount of protein lost into the perfusate was 0.35 ± 0.22 g/kg body weight in the CHPP group and 0.37 ± 0.19 g/kg in the CNPP group, showing no significant difference. On the day of surgery, there was no significant difference in the amount of protein and fluid lost through the abdominal drains between the CHPP group (27.9 ± 24.6 mg/kg/hr and 0.94 ± 0.63 ml/kg/hr, respectively) and the CNPP group (25.9 ± 8.6 mg/kg/hr and 1.03 ± 0.31 ml/kg/hr, respectively). We could not find any significant differences in postoperative protein and fluid loss between the groups on the following 3 days either. We conclude that the peritoneal damage by CHPP is not caused by the hyperthermia but by the peritoneal perfusion with saline solution containing anticancer drugs.
Preincisional Dextromethorphan Treatment for Postoperative Pain Management after Upper Abdominal Surgery
Authors: Wu Ching‐Tang , Yu Jyh‐Cherng , Liu Sy‐Tzu , Yeh Chun‐Chang , Li Chi‐Yuan , Wong Chih‐Shung 
Published: August 2002

Abstract.Previous studies showed that ketamine, an N‐methyl‐d‐aspartate (NMDA) receptor antagonist, provides a preemptive analgesic effect and preemptive analgesia improves postoperative pain management. The aim of this study was to examine whether premedication with dextromethorphan (DM) improves postoperative pain management after upper abdominal surgery. Sixty (American Society of Anesthesiologists class 1 and 2 of either gender) patients scheduled for upper abdominal surgery were included in the study. Patients were randomly assigned to one of four groups: control, DM‐10, DM‐20, and DM‐40. In the control group, chlorpheniramine maleate (CPM, 20 mg) was injected immediately before induction of anesthesia intramuscularly (IM). In the DM‐10, DM‐20, and DM‐40 groups, patients were premedicated with DM 10 mg, 20 mg, and 40 mg IM, respectively. After operation, patient‐controlled analgesia (PCA) with morphine was given for pain relief. The time to the first PCA trigger, morphine consumption, pain scores, and analgesic‐related side effects were recorded at 1, 2, 4, 24, 48, and 72 hours after surgery. The time to first PCA trigger for the control group was 17.8 ± 1.4 minutes, for group DM‐10 20.2 ± 1.6 minutes, for group DM‐20 32.4 ± 1.9 minutes, and for DM‐40 77.9 ± 6.5 minutes. The morphine delivered and PCA triggering frequency were 5.5 ± 0.5/11.3 ± 0.8 times for the controls, 5.5 ± 0.4/14.1 ± 1.3 times for DM‐10, 3.1 ± 0.3/6.3 ± 1.2 times for DM‐20, and 0.2 ± 0.1/0.3 ± 0.2 times for DM‐40 during the first hour after operation. For the first day, the figures are 19.9 ± 1.2/23.9 ± 1.4 for the controls, 15.6 ± 1.2/17.3 ± 2.4 for DM‐10, 12.6 ± 0.7/15.9 ± 1.6 for DM‐20, and 5.0 ± 0.21/5.6 ± 0.9 for DM‐40. On the first day, the cough pain scores were 6.67 ± 0.23, 6.53 ± 0.16, 6.67 ± 0.23, and 5.73 ± 0.18 for the controls, DM‐10, DM‐20, and DM‐40 groups, respectively. All data showed dose‐dependent better pain relief in DM‐premedicated patients. We conclude that DM premedication offers preemptive analgesia and reduces postoperative pain and morphine requirement.
Measuring the Tumor Volume of Gastric Carcinoma by Computer Image Analysis: Clinical Significance
Authors: Kikuchi Shiro , Hiki Yoshiki , Sakakibara Yuzuru , Kakita Akira , Kuwao Sadahito 
Published: August 2002

Abstract.The tumor diameter of gastric carcinoma, measured by gross or histologic examination, is a rough indicator of actual tumor size. Therefore we investigated the utility of three‐dimensional reconstruction of tumors in gastric carcinoma. Altogether 105 primary gastric carcinoma lesions, consisting of 16 advanced and 89 early carcinomas, were analyzed. A total of 942 lesion tissue sections, comprising 2 to 37 sections per lesion (mean 9 sections), were examined histologically. Surface rendering using a computer graphics analysis program was then performed from serial sections to create a three‐dimensional reconstruction of tumor morphology from which to measure tumor volume. For the 105 lesions the tumor diameter ranged between 4 and 106 mm (average ± SE: 32.4 ± 2.0 mm), and tumor volume ranged between 4 and 5853 mm3 (average ± SE: 773.0 ± 104.6 mm3). A significant correlation was found between tumor diameter and the log of the tumor volume (r= 0.733, p < 0.0001). Although the logs of tumor volume for advanced carcinomas were all > 2.5, in 11 of these 16 patients (66%) the tumor diameter was < 4 cm, and in one patient < 2 cm. In addition, tumor diameter did not differ significantly between the 16 advanced and the 89 early gastric carcinomas (p= 0.114), whereas the log of the tumor volume did (p < 0.0001). In conclusion, conventional measurements of tumor diameter as a rough indicator of tumor size can predict the actual tumor size of a gastric carcinoma. Three‐dimensional reconstruction using computer graphics provides a better estimation of true tumor size and extent of progression than tumor diameter.
The Effects of Doxycycline on Nitric Oxide and Stromelysin Production in Dogs With Cranial Cruciate Ligament Rupture
Authors: Jauernig Silvia , Schweighauser Ariane , Reist Martin , Von Rechenberg Brigitte , Schawalder Peter , Spreng David 
Published: August 2002

Objective—To investigate the potential of doxycycline to reduce stromelysin and inducible nitric oxide synthase (iNOS) activity in dogs with osteoarthritis (OA) secondary to spontaneous cranial cruciate ligament (CCL) rupture.Study Design—Prospective, clinical study.Animals—Eighty‐one dogs with OA secondary to CCL rupture and 54 normal dogs.Methods—Dogs with OA secondary to CCL rupture were divided into 2 groups before surgery. The Doxy‐CCl group received 3 to 4 mg/kg doxycycline orally every 24 hours for 7 to 10 days (n = 35). The CCL group received no treatment (n = 46). Synovial fluid, articular cartilage, synovial membrane, and CCL samples were collected during surgery (Doxy‐CCL group and CCL group) or immediately after euthanasia from healthy dogs (control group). Synovial fluid samples were examined cytologically. Total nitric oxide (NOt) concentrations were measured in the supernatant of explant cultures of all tissue samples, and stromelysin activity was measured in the supernatant of explant cultures of cartilage.Results—NOtconcentrations measured in cartilage were significantly lower in the Doxy‐CCL group than in the CCL group, but were not different from those measured in the control group. Doxycycline treatment did not have a significant effect on cartilage stromelysin levels.Conclusion—The findings in this study indicate that doxycycline inhibits NO production in cartilage in dogs with CCL rupture.Clinical Relevance—Doxycycline may have a role in the treatment of canine OA by inhibiting NO production.
T‐γ large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, Sjögren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia
Authors: Ergas David , Tsimanis Alexander , Shtalrid Mordechai , Duskin Chen , Berrebi Alain 
Published: August 2002

AbstractWe present a female patient with T‐γ LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic thrombocytopenic purpura, and finally pure red cell aplasia. PCR analysis confirmed rearrangement for TCR γ. This case emphasizes the complex association of LGL leukemia with autoimmune disorders. Am. J. Hematol. 69:132–134, 2002. © 2002 Wiley‐Liss, Inc.
Molecular characteristics of pediatric patients with sickle cell anemia and stroke
Authors: Sarnaik Sharada A. , Ballas Samir K. 
Published: August 2002

AbstractCerebrovascular accidents (CVA) are serious complications of sickle cell anemia (SS) in children. Factors that predispose children to this complication are not well established. In an effort to elucidate the risk factors associated with CVA in SS, we have determined the α‐globin genotype and the βS haplotype of children with this complication. Among 700 children with SS followed at Children's Hospital of Michigan, 41 (6%) are on chronic transfusions because of stroke due to cerebral infarction. The mean age of patients with CVA at the time of stroke was 5.6 ± 3.2 years (mean ± SD). The male/female ratio was 2/3. Only 8 of 41 patients (19.5%) had one α‐gene deletion, compared to the reported prevalence of 30% in African‐Americans. None of the patients had two α‐gene deletions, and two (5%) had five α‐genes. These findings are different than those in our adult patients with SS, where the prevalence of −α/−α and ααα/αα is 4% and <2%, respectively. Ten different βS‐haplotypes were detected in the patients studied. The majority of the patients (31%) were doubly heterozygous for the Ben/CAR haplotypes followed by Ben/Ben, Ben/Sen, and CAR/CAR haplotypes, respectively. The prevalence of these haplotypes, with the exception of the CAR/CAR haplotype, was higher in females than males. All the patients with CAR/CAR haplotype were males, had four α‐genes, and ranked third in prevalence. Three patients were heterozygous for the Cameron haplotype. The Cameron and atypical haplotypes were more prevalent than reported in patients with SS at large. The data suggest that CVA in children seems to occur more frequently in females and in patients with certain βS haplotype. α‐Gene deletion seems to offer a protective effect against this complication. Neonates with four or more α‐genes whose βS haplotype is Ben/CAR, atypical, or CAR/CAR seem to be at a higher risk for CAV than other patients. A prospective study on a larger group of patients with or without CVA may clarify this issue. Am. J. Hematol. 67:179–182, 2001. © 2001 Wiley‐Liss, Inc.
Nested case‐control analysis of high pesticide exposure events from the Agricultural Health Study
Authors: Alavanja Michael C. R. , Sprince Nancy L. , Oliver Eugene , Whitten Paul , Lynch Charles F. , Gillette Patricia P. , Logsden‐Sacket Nyla , Zwerling Craig 
Published: August 2002

AbstractBackgroundA nested case‐control analysis of high pesticide exposure events (HPEEs) was conducted using the Iowa farmers enrolled in the Agricultural Health Study (AHS).MethodsIn the 12 months of the study, 36 of the 5,970 farmer applicators randomly chosen from the AHS cohort (six per 1,000 farmer applicators per year) met our definition of an HPEE, by reporting “an incident with fertilizers, weed killers, or other pesticides that caused an unusually high personal exposure” resulting in physical symptoms or a visit to a health care provider or hospital. Eligibility criteria were met by 25 HPEE cases and 603 randomly selected controls.ResultsSignificant risk factors for an HPEE included: poor financial condition of the farm which limited the purchase of rollover protective structures OR = 4.6 (1.5–16.6), and having a high score on a risk acceptance scale OR = 3.8 (1.4–11.2). Other non‐significant factors were also identified.ConclusionsThe limited statistical power of this study necessitates replication of these analyses with a larger sample. Nonetheless, the observed elevated odds ratios of an HPEE provide hypotheses for future studies that may lead to preventive action. Am. J. Ind. Med. 39:557–563, 2001. © 2001 Wiley‐Liss, Inc.
The 5‐HT2A receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients
Authors: Arias Bárbara , Gastó Cristobal , Catalán Rosa , Gutiérrez Blanca , Pintor Luis , Fañanás Lourdes 
Published: August 2002

AbstractSeveral lines of evidence suggest that genetic factors constitute an important determinant of suicidal behavior. A significant association between the 5‐HT2A‐C allele and suicidality has recently been reported. The aim of this study was to investigate whether the proposed association between 5‐HT2A‐102T/C polymorphism and suicidality could be replicated in a larger and independent sample of Spanish patients with major depression. The 102T/C polymorphism of the 5‐HT2A receptor gene was analyzed in 159 patients with major depression (DSM‐IV criteria) and 164 unrelated and healthy controls using a case control design. All individuals were subjects of Spanish origin. Significant differences in allele (chi‐square = 4.13, df = 1, P = 0.04) and genotype (chi‐square = 6.19, df = 2, P = 0.04) distributions were found between non–suicide attempters and suicide attempters. Moreover, those patients carrying 5‐HT2A‐C allele had more than five times the risk for attempting suicide than noncarriers (OR = 5.50, 95% CI = 1.18–35.20, P = 0.01). Our results replicate the proposed association between 5HT2A‐C allele and suicidality in major depression. Moreover, no overall associations are detected when patients with major depression and controls are compared for 102T/C frequencies, suggesting that the increased risk for suicidality conferred by 5‐HT2A‐C allele is primarily associated with suicidal behavior and not with the diagnosis of major depression itself. © 2001 Wiley‐Liss, Inc.
Common mutations of ATP7B in Wilson disease patients from Hungary
Authors: Firneisz Gábor , Lakatos Péter L. , Szalay Ferenc , Polli Claudia , Glant Tibor T. , Ferenci Peter 
Published: August 2002

AbstractWilson disease (WD) is an autosomal recessive disorder of copper metabolism. The H1069Q mutation in exon 14 of ATP7B is far the most frequent in Wilson patients of European origin. Mutations in exon 8 and 15 are also common among the over 150 described mutations in the WD gene. The aim was to investigate the frequency of these common WD gene mutations in Hungarian patients. A total of 42 patients with WD from 39 Hungarian families were examined. The H1069Q mutation was assessed by a seminested polymerase chain reaction (PCR)‐based restriction fragment length polymorphism (RFLP) assay, while mutations in exons 8, 13, 15, and 18 of WD gene were identified by sequencing. In addition, haplotype analysis was performed using three common microsatellite markers (D13S314, D13S301, D13S316). The H1069Q mutation was found in 27 patients (64.3%). Nine patients were H1069Q homozygous. Eighteen patients were H1069Q compound heterozygous, two of them had H1069Q/P969Q and one patient H1069Q/3400delC genotype. In two of the 15 H1069Q‐negative patients a novel mutation in exon 13 (T977M) was detected. One H1069Q‐negative patient had a mutation in exon 8 (G710S). None of the studied mutations was detected in 12 WD patients. H1069Q‐positive patients from various European countries had the same haplotype pattern. The H1069Q point mutation is frequent in Hungarian patients with WD and appears to have originated from a single founder in Eastern Europe. In contrast, mutations in exons 8, 13, 15, and 18 are uncommon in Hungarian WD patients. © 2002 Wiley‐Liss, Inc.
Complete overlap of PHACE syndrome and sternal malformation—vascular dysplasia association
Authors: James Paul A. , McGaughran Julie 
Published: August 2002

AbstractPHACE syndrome is the term applied to the association of posterior fossa brain abnormalities, hemangiomas, arterial anomalies in the cranial vasculature, coarctation of the aorta/cardiac defects, and eye abnormalities. An overlap with the sternal malformation/vascular dysplasia association has been described. We report an adult patient with complete manifestations of both conditions. As an adult she has demonstrated resolution of the hemangiomas and only mild intellectual difficulties.