bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow Control Over a Finite Wall-Mounted Square Cylinder by Using Multiple Plasma Actuators
Authors: Yousif Mustafa Z. , Yang Yifang , Zhou Haifeng , Mohammadikarachi Arash , Yu Linqi , Zhang Meng , Lim Hee-Chang 
Published: December 2023

Abstract
The present study aims to investigate the effectiveness of plasma actuators in controlling the flow around a finite wall-mounted square cylinder (FWMSC) with a longitudinal aspect ratio of 4. The test is conducted in a small-scale closed return-type wind tunnel. The Reynolds number of the experiments, Red, is 500 based on the width of the bluff body and the freestream velocity. The plasma actuators are installed on the top surface and the rear surface of the square cylinder. The induced flow velocities of the plasma actuators are modulated by adjusting the operating voltage and frequency of the high-voltage generator. In this work, particle image velocimetry (PIV) is used to obtain the velocity fields. Furthermore, force calculations are conducted to investigate the effect of using plasma actuators with different driving voltages on the drag force. Our results show that the plasma actuators can successfully suppress flow separation and reduce the turbulent kinetic energy (TKE) in the wake. A correlation between the drag coefficient and the operating voltage of the power generator is also revealed, and the mean drag coefficient is found to decrease with increasing imposing voltage. The plasma actuators can enhance the momentum exchange and the interactive behavior between the shear layer and the flow separation region, resulting in flow reattachment at the free end and shrinkage of the recirculation zone in the near-wake region of the bluff body. Overall, the present study demonstrates the practical effectiveness of using plasma actuators for flow control around FWMSC.
Mitofusin-2 Regulates Platelet Mitochondria and Function
Authors: Jacob Shancy , Kosaka Yasuhiro , Bhatlekar Seema , Denorme Frederik , Benzon Haley , Moody Alexandra , Moody Victoria , Tugolukova Emilia A. , Hull Grayson , Kishimoto Nina , Manne Bhanu K. , Guo Li , Souvenir Rhonda , Seliger Brayden J. , Eustes Alicia S. , Hoerger Kelly , Tolley Neal D. , Fatahian Amir N. , Boudina Sihem , Christiani David C. , Wei Yongyue , Ju Can , Campbell Robert A. , Rondina Matthew T. , Abel E. Dale , Bray Paul F. , Weyrich Andrew S. , Rowley Jesse W. 
Published: December 2023

BACKGROUND:

Single-nucleotide polymorphisms linked with the rs1474868 T allele (
MFN2
[mitofusin-2] T/T) in the human mitochondrial fusion protein
MFN2
gene are associated with reduced platelet
MFN2
RNA expression and platelet counts. This study investigates the impact of MFN2 on megakaryocyte and platelet biology.

METHODS:

Mice with megakaryocyte/platelet deletion of
Mfn2
(
Mfn2
−/−
[
Mfn2
conditional knockout]) were generated using Pf4-Cre crossed with floxed
Mfn2
mice. Human megakaryocytes were generated from cord blood and platelets isolated from healthy subjects genotyped for rs1474868. Ex vivo approaches assessed mitochondrial morphology, function, and platelet activation responses. In vivo measurements included endogenous/transfused platelet life span, tail bleed time, transient middle cerebral artery occlusion, and pulmonary vascular permeability/hemorrhage following lipopolysaccharide-induced acute lung injury.

RESULTS:

Mitochondria was more fragmented in megakaryocytes derived from
Mfn2
−/−
mice and from human cord blood with
MFN2
T/T genotype compared with control megakaryocytes. Human resting platelets of
MFN2
T/T genotype had reduced MFN2 protein, diminished mitochondrial membrane potential, and an increased rate of phosphatidylserine exposure during ex vivo culture. Platelet counts and platelet life span were reduced in
Mfn2
−/−
mice accompanied by an increased rate of phosphatidylserine exposure in resting platelets, especially aged platelets, during ex vivo culture.
Mfn2
−/−
also decreased platelet mitochondrial membrane potential (basal) and activated mitochondrial oxygen consumption rate, reactive oxygen species generation, calcium flux, platelet-neutrophil aggregate formation, and phosphatidylserine exposure following dual agonist activation. Ultimately,
Mfn2
−/−
mice showed prolonged tail bleed times, decreased ischemic stroke infarct size after cerebral ischemia-reperfusion, and exacerbated pulmonary inflammatory hemorrhage following lipopolysaccharide-induced acute lung injury. Analysis of
MFN2
SNPs in the iSPAAR study (Identification of SNPs Predisposing to Altered ALI Risk) identified a significant association between
MFN2
and 28-day mortality in patients with acute respiratory distress syndrome.

CONCLUSIONS:
Mfn2 preserves mitochondrial phenotypes in megakaryocytes and platelets and influences platelet life span, function, and outcomes of stroke and lung injury.
Cost‐Effectiveness of Icosapent Ethyl in REDUCE‐IT USA: Results From Patients Randomized in the United States
Authors: Weintraub William S. , Bhatt Deepak L. , Zhang Zugui , Dolman Sarahfaye , Boden William E. , Bress Adam P. , Bellows Brandon K. , Derington Catherine G. , Philip Sephy , Steg Gabriel , Miller Michael , Brinton Eliot A. , Jacobson Terry A. , Tardif Jean‐Claude , Ballantyne Christie M. , Kolm Paul 
Published: December 2023

Background
In 3146 REDUCE‐IT USA (Reduction of Cardiovascular Events With Icosapent Ethyl Intervention Trial USA) participants, icosapent ethyl (IPE) reduced first and total cardiovascular events by 31% and 36%, respectively, over 4.9 years of follow‐up.

Methods and Results
We used participant‐level data from REDUCE‐IT USA, 2021 US costs, and IPE costs ranging from $4.59 to $11.48 per day, allowing us to examine a range of possible medication costs. The in‐trial analysis was participant‐level, whereas the lifetime analysis used a Markov model. Both analyses considered value from a US health sector perspective. The incremental cost‐effectiveness ratio (incremental costs divided by incremental quality‐adjusted life‐years) of IPE compared with standard care (SC) was the primary outcome measure. There was incremental gain in quality‐adjusted life‐years with IPE compared with SC using in‐trial (3.28 versus 3.13) and lifetime (10.36 versus 9.83) horizons. Using an IPE cost of $4.59 per day, health care costs were lower with IPE compared with SC for both in‐trial ($29 420 versus $30 947) and lifetime ($216 243 versus $219 212) analyses. IPE versus SC was a dominant strategy in trial and over the lifetime, with 99.7% lifetime probability of an incremental cost‐effectiveness ratio <$50 000 per quality‐adjusted life‐year gained. At a medication cost of $11.48 per day, the cost per quality‐adjusted life‐year gained was $36 208 in trial and $4135 over the lifetime.

Conclusions
In this analysis, at $4.59 per day, IPE offers better outcomes than SC at lower costs in trial and over a lifetime and is cost‐effective at $11.48 per day for conventional willingness‐to‐pay thresholds. Treatment with IPE should be strongly considered in US patients like those enrolled in REDUCE‐IT USA.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01492361.
Criminalization of Childlike Sex Dolls under International and EU Law
Authors: Loibl Elvira , van der Aa Suzan 
Published: December 2023

Abstract
Recent years have witnessed the emergence of a market in childlike sex dolls. Even though there is currently no empirical evidence as to whether or not the use of childlike sex dolls would prevent or encourage sexual abuse of children, more and more countries prohibit or consider prohibiting them. However, it is unclear as to where international and EU law stand in relation to these dolls. This article analyses and discusses international and EU legal instruments that might be relevant for a national ban on childlike sex dolls. First, it deals with the question whether the international and EU legal framework on child pornography and other relevant instruments provide a legal basis for prohibiting these objects. Second, it examines whether a ban on childlike sex dolls is compatible with international and EU trade law, in particular with the 1994 General Agreement on Tariffs and Trade and the Treaty on the Functioning of the European Union.
Climate Breakdown and Book Publishing
Authors: Hodgkin Adam 
Published: December 2023

Abstract
This article notes the ever-increasing urgency of immediate action on climate change across all sectors. The publishing industry is aware of the need for action, measurement, auditing, and detailed reporting. Two of the largest STM (scientific, technical, and medical) publishers, Springer Nature and Elsevier, have started publishing annual reports covering their activity on climate change and sustainability. The article also considers attempts that have been made to measure the carbon impact of individual books. Such studies are inconclusive, and may not be helpful if the physical product is still GHG (greenhouse gas) costly in a time when all sectors need to drastically curtail GHG impact. The paper notes the need for continuing and sustained focus on mitigation and adaptation and suggests that the prospects for highly inventive adaptation through the long-established and growing ‘digital turn’ ongoing in publishing for 60 years are encouraging. A full digital transformation may yet be possible, necessary, and able even, in effect, to subtract the GHG costs of paper publishing from the global balance sheet measuring our climate breakdown.
Colexification of ‘Enough’, ‘Able’ and ‘Until’ in Tok Pisin and Papapana: Independent or Contact-induced Change?
Authors: Smith-Dennis Ellen 
Published: December 2023

Abstract
Considerable research has concerned the influence of Papua New Guinea’s Oceanic languages on the development of the pidgin/creole Tok Pisin, but little research has considered linguistic influence in the opposite direction. This paper adds to both bodies of research by investigating whether the colexification of ‘enough’, ‘able’ and ‘until’ in Papapana (Oceanic) and Tok Pisin results from internal or contact-induced change. Such a colexification is unattested/rare cross-linguistically therefore I argue that language contact is responsible. The Tok Pisin verb inap ‘enough, able’ grammaticalised as the preposition/subordinator ‘until’ because of semantic extensions by Oceanic language speakers whose languages demonstrate overlapping polysemies. The Papapana verb eangoi colexifies ‘enough’ and ‘able’ (common cross-linguistically), but the colexification with the lexicalised adverb eangoiena ‘able’ and grammaticalised preposition/subordinator eangoiena ‘until’ is pattern replication modelled on Tok Pisin. Based on areal data, I propose a tentative semantic map for enough, contributing to research on cross-linguistic colexification.
Quṭb al-Dīn al-Shīrāzī’s Commentary on Ibn Sīnā’s Qānūn in Historical Context: Edition and Translation of the Preface
Authors: Savadi Fateme , Eshera Osama 
Published: December 2023

Abstract
Ibn Sīnā’s al-Qānūn fī l-ṭibb, especially its first book, al-Kulliyyāt, elicited dozens of commentaries from the 6th/12th century through the 8th/14th century. Among them, Quṭb al-Dīn al-Shīrāzī’s commentary, entitled al-Tuḥfa al-saʿdiyya, is distinguished in that in it he analyzed and synthesized almost all commentaries written before his death in 710/1311. This article shows how Shīrāzī bridged some of the political boundaries that divided the Islamic world after the Mongol invasion to gather his predecessors’ commentaries, as well as other sources for composing al-Tuḥfa al-saʿdiyya. Shīrāzī’s extensive travels and proximity to patronage allowed him to acquire, and later disseminate, medical and scientific texts that were otherwise unavailable in Anatolia and the eastern territories of the Islamic world.
Words and their Worlds: A Conversation with Dilip M. Menon
Authors: Al-Zayed Mahmoud 
Published: December 2023

Abstract
In this Philological Conversation, Dilip M. Menon dwells on the questions of how to think concepts and theorize from the Global South and on writing history beyond the Eurocentric, colonial, nationalist, and terrestrial. We discuss the political and epistemic implications and consequences of such urgent tasks. Dilip M. Menon speaks about his affinities with Edward Said, Mikhail Bakhtin, and Walter Benjamin, among others, and refects on the themes of coloniality of knowledge, postcoloniality, decoloniality, oceanic history, and the idea of paracoloniality. He links his earlier works to his recent decolonial intellectual projects and discusses his intellectual formation and his practice as a historian and social theorist. Put together via e-mail exchanges, this conversation is a culmination of several in-person conversations that took place in Beirut, Delhi and Berlin. One only hopes for many more to come.
Automated and Objective Thunderstorm Identification and Tracking Using Geostationary Lightning Mapper (GLM) Data
Authors: Murphy Kelley M. , Carey Lawrence D. , Schultz Christopher J. , Curtis Nathan , Calhoun Kristin M. 
Published: December 2023

Abstract
A unique storm identification and tracking method is analyzed in varying storm environments within the United States spanning 273 hours in 2018. The methodology uses a quantity calculated through fusion of radar-based vertically integrated liquid (VIL) and satellite-based GLM flash rate density (FRD) called VILFRD to identify storms in space and time. This research analyzes GLM data use within VILFRD for the first time (method original: O), assesses four modifications to VILFRD implementation to find a more stable storm size with time (method new: N), larger storms (method original dilated: OD), or both (method new dilated: ND), and compares VILFRD methods with storm tracking using the 35-dBZ isosurface at −10°C (method non-VILFRD: NV). A case study analysis from 2019 is included to assess methods on a smaller scale and introduce a “lightning only” (LO) version of VILFRD. Large study results highlight that VILFRD-based storm identification produces smaller storms with more lightning than the NV method, and the NV method produces larger storms with a more stable size over time. Methods N and ND create smaller storm size fluctuations, but size changes more often. Dilation (OD, ND) creates larger storms and almost double the number of storms identified relative to nondilated methods (O, N, NV). The case study results closely resemble the large sample results and show that the LO method identifies storms with more lightning and shorter durations. Overall, these findings can aid in choice of storm tracking method based on desired user application and promote further testing of a lightning-only version of VILFRD.
Northern Hemisphere Extratropical Cyclone Clustering in ERA5 Reanalysis and the CESM2 Large Ensemble
Authors: Karwat Alexia , Franzke Christian L. E. , Pinto Joaquim G. , Lee Sun-Seon , Blender Richard 
Published: December 2023

Abstract
Extratropical cyclones are a dominant feature of the midlatitudes, and often occur as storm sequences. This phenomenon is known as cyclone clustering, which is common over regions like the eastern North Atlantic and western Europe. Here, intense clustered cyclones may lead to large cumulative socioeconomic impacts. There are several different approaches to quantify cyclone clustering, but a detailed evaluation on how clustering may change in a warmer climate is missing. We perform a cyclone clustering analysis for the Northern Hemisphere midlatitudes using the ERA5 reanalysis to characterize clustering during 1980–2020. Moreover, we use large ensemble simulations of the Community Earth System Model version 2 following the SSP3-7.0 scenario to compare clustering during 2060–2100 to 1980–2020. Our model simulations show significant enhancement in cyclone clustering over Europe for 3 and 4 cyclones within 7 days in the future decades, which is increasing by up to 25% on average during 2060–2100 compared to 1980–2020. In contrast, cyclone clustering decreases along the west coast of the United States and Canada by up to 24.3% and by 10.1% in the Gulf of Alaska for the same periods. In a warmer climate, clustered cyclones have lower minimum pressure and larger radii and depths compared to nonclustered events. Our findings suggest that change in future cyclone clustering depends on regions affected by global warming, with implications for the cumulative windstorm risk.

Significance Statement
Storm sequences like the one of December 1999 (Anatol, Lothar, and Martin) have led to large socioeconomic impacts in Europe. It is still unclear how such events will change under global warming. We analyze storm sequences in a reanalysis and a large climate model ensemble for recent (1980–2020) and future climate conditions (2060–2100). Our results show a significant enhancement of storm sequences over Europe for 3 and 4 storms within 7 days, while a decrease is found along the west coast of the United States, western Canada, and in the Gulf of Alaska in future decades. Our findings suggest that the characteristics of cyclone clustering may change in a warmer world, and thus also the associated impacts.
Agomelatine efficacy in treatment resistant obsessive-compulsive disorder: A randomized controlled trial
Authors: Nejati Azadeh , Bazrafshan Amir , Mosavat Seyed Hamdollah 
Published: December 2023

Background Obsessive-compulsive disorder (OCD) is a prevalent and burdensome mental health condition, often resistant to conventional treatments. Agomelatine (Valdoxan), a compound acting on serotonin and melatonin systems, has shown promise in treating those with treatment-resistant OCD based on anecdotal reports and case studies. Methods A randomized, double-blind controlled trial was conducted with 60 patients diagnosed with treatment-resistant OCD. Participants were randomized into an intervention group (receiving agomelatine 50 mg/day) and a control group (receiving placebo). OCD symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) over a 12-week period. Results There were no significant differences in age, gender, or baseline Y-BOCS scores between intervention and control groups. Agomelatine did not demonstrate a significant improvement in OCD symptoms compared to placebo. Adverse events were comparable between groups, and liver enzyme levels remained within the normal range. Conclusion This study, while not confirming superior efficacy compared to placebo, underscores the need for continued investigation into agomelatine’s potential for treating specific subgroups of OCD patients, underscoring the need for more comprehensive and well-controlled trials in the future.
Development of urinary diary mobile application and evaluation in patients with urinary incontinence
Authors: Aydın Serdar , Yaşlı Mert , Kunt Atilla 
Published: December 2023

Objective: To develop a feasible smartphone urinary diary application (UDA), and evaluate reliability and patient acceptability as a collection, calculation, and sharing tool. Materials and Methods: We developed the UDA for smartphones, which collects voiding, leakage, fluid intake, and grade of urgency data. A two-way cross-sectional study was conducted with 60 participants, participants split into two groups. Thirty participants completed UDA for 3 days either preceded or followed by a standard paper diary. We assessed the paper app reliability of the UDA with the Kappa variable and internal correlation coefficient (ICC). Results: 29 (96.6%) participants completed the 3-day UDA in the first phase, 92.6% in the second phase, in comparison to 90% and 79.4% in paper form, respectively. Incomplete variable recording was observed at 10.3%–20% in the UDA group in comparison to 33.3%–34.8 % in the PF group. Of the 48 participants who experienced both diaries, 40 (83.3%) preferred the UDA. Paper app correlation was good to very good with ICC ranging from 0.60 to 0.90 for all variables ( p < 0.001). Kappa values for incontinence, stress incontinence, urge incontinence, and increased frequency were 0.95, 0.94, 0.82 0.87, and 0.54; respectively ( p < 0.001). Conclusion: The performance of developed smartphone UDA is comparable with and highly correlated with paper form with most users finding the app feasible. Convergent validity with urinary incontinence and other lower urinary tract dysfunctions is required.
Sleep Duration Is Associated with Household Food Insecurity and Sugar-Sweetened Beverage Intake Among Women, Infants and Children Participating Children Ages 0-5
Authors: Yepez Catherine E. , Anderson Christopher E. , Frost Erin , Whaley Shannon E. , Koleilat Maria 
Published: December 2023

Purpose To determine associations between child and household characteristics and sleep duration among low-income children in Los Angeles County. Design Cross-sectional study. Setting Survey data collected in 2017 and 2020 in Los Angeles County, California. Sample Special Supplemental Nutrition Program for Women, Infants and Children (WIC) households with children ages 4-60 months. Measures Sleep duration for children 4-60 months old (less than recommended (LTR), recommended range, more than recommended (MTR)), household food insecurity (HFI), sociodemographics, and daily servings of sugar-sweetened beverages (SSB). Analysis Multinomial logistic regression, stratified by child age, was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between household/child characteristics and LTR or MTR sleep compared to recommended duration among WIC participating children 4-60 months old. Results The final sample included 3512 children ages 4-23 months and 6035 children ages 24-60 months. In the study population, 32% (3-5 years old) to 44% (4-11months) of children under 5 did not meet the recommended hours of sleep per night. HFI was associated with higher odds of LTR (OR 1.27, CI 1.12-1.45) and MTR (OR 1.46, CI 1.15-1.87) sleep among 24-60 month-old children. Each additional daily SSB serving was associated with higher odds of LTR sleep (4-23 months: OR 1.10, CI 1.02-1.19; 24-59 months: OR 1.12, CI 1.08-1.17). Conclusions HFI and SSB intake are associated with not getting the recommended amount of sleep among low-income WIC participating children. Nutrition assistance program participants may benefit from receiving information about recommended sleep duration for young children and how to establish sleep routines to optimize sleep duration.
Impact of FinTech Growth on Bank Performance in GCC Region
Authors: Litimi Houda , BenSaïda Ahmed , Raheem Mohamed Mahees 
Published: December 2023

This article investigates the effect of financial technology (FinTech) growth on bank performance in the Gulf Cooperation Council (GCC) region. The application is conducted on a panel dataset containing annual observations of banks from 2012 to 2021 using the generalized method of moments (GMM) method. FinTech growth is set as an explanatory variable on three proxies of bank performance, namely, return on assets (ROA), return on equity (ROE), and net interest margin (NIM). Moreover, several control variables are added to the model, including bank-specific and macroeconomic variables. The results are significant as all the proxies of bank performance are negatively affected by the growth of FinTech startups. Consequently, banks are urged to proactively invest in FinTech startups and engage in partnerships to avoid the risk of disruption. JEL Codes: G21, G23, O31