bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative Parathormone Measurement in Patients with Multiple Endocrine Neoplasia Type I Syndrome and Hyperparathyroidism
Authors: Tonelli Francesco , Spini Simona , Tommasi Mariasilvia , Gabbrielli Gianfranco , Amorosi Andrea , Brocchi Alessandro , Brandi Maria Luisa 
Published: August 2002

Abstract.Total or subtotal parathyroidectomy is considered the treatment of choice for multiple endocrine neoplasia type I (MEN‐I)‐associated primary hyperparathyroidism (HPT). However, persistent or recurrent HPT is frequently observed. The development of a rapid two‐site immunoradiometric assay (IRMA) method for measuring intact parathormone (PTH) has provided a valuable tool for recognizing possible surgical failures. Our experience includes 16 MEN‐I patients (10 females, 6 males) of mean age 35.5 years operated on between 1990 and 1996. Total parathyroidectomy (TPTX) with autotransplantation of parathyroid tissue was the standard treatment. Blood samples for PTH measurement were drawn at the induction of anesthesia (basal value), 10 and 20 minutes after the removal of each gland, and 60 minutes after TPTX. Rapid PTH measurement, which required only 15 minutes of incubation at 37°C, showed a highly significant correlation (p < 0.0001) with the standard method. Circulating PTH levels exhibited a stepwise decrease during TPTX, reaching a mean value of 22.3% of the baseline 20 minutes after removal of the last gland. Two patients showed a prompt decrease of PTH after removal of the single enlarged gland, featuring the kinetics observed in the adenomas. One of these two patients was successfully treated with more conservative surgery. None of the patients showed persistence or recurrence of HPT. In our experience, intraoperative measurement of PTH seems to be a valuable adjunct in both the diagnosis of multiglandular involvement and the prediction of surgical treatment in patients with primary parathyroid hyperplasia.
Various population fluctuation patterns of light‐attracted beetles in a tropical lowland dipterocarp forest in Sarawak
Authors: Kato M. , Itioka T. , Sakai S. , Momose K. , Yamane S. , Hamid A. A. , Inoue T. 
Published: August 2002

AbstractThe population fluctuation pattern of light‐attracted beetles was studied from August 1992 to September 1998 (for 73 months) using ultraviolet light‐traps set at three vertical levels in a tropical lowland dipterocarp forest in Sarawak, Malaysia. During our study, a general flowering occurred from April to July in 1996, and flowering on a small scale in 1997 and 1998. We analyzed the data for eight scarabaeid and six meloid species, some of which were anthophilous species. Various fluctuation patterns were observed among the beetle species in aspects of both seasonality and correlation with the supraannual phenological pattern. Three large chafer species (Scarabaeidae, Melolonthini) showed a clear seasonal fluctuation pattern with a peak once from March to May every year, the peak monthly catch greatly fluctuating annually. Other scarabaeid beetles did not show such a clear seasonal population pattern and hardly fluctuated annually. Populations of an anthophilous scarabaeid species, Parastasia bimaculata, a specific pollinator of Homalomena propinqua (Araceae), hardly fluctuated, probably because of its response to the constant flowering of its floral hosts. Monthly catches of an anthophilous scarabaeid, Anomala sp., and meloid beetles showed clear supraannual patterns in response to the general flowering and were significantly correlated with the flowering intensity with or without a lag of a month. The fluctuation pattern of meloids suggests a supraannual population fluctuation pattern of their hosts, i.e., megachilid/anthophorid bees.
Arthrodesis of the Equine Proximal Interphalangeal Joint: A Biomechanical Comparison Of Three 4.5‐mm and Two 5.5‐mm Cortical Screws
Authors: Watt Bruce C. , Edwards Ryland B. , Markel Mark D. , McCabe Ron , Wilson David G. 
Published: August 2002

Objective— To compare the biomechanical characteristics and mode of failure of 2 parallel‐screw techniques for proximal interphalangeal joint arthrodesis in horses.Study Design— Randomized block design, blocking for horse (1–5), method of screw fixation (three 4.5‐mm vs two 5.5‐mm), side (left limb vs right limb), and end (front limb vs hind limb). Constructs were loaded to failure in 3‐point bending in a dorsal‐to‐palmar (plantar) direction.Sample Population— Twenty limbs (10 limb pairs) from 5 equine cadavers.Methods— A combined aiming device was used to facilitate consistent screw placement. Three parallel 4.5‐mm cortical screws were placed in lag fashion in 1 limb of a pair, and 2 parallel 5.5‐mm cortical screws were placed in lag fashion in the contralateral limb. Arthrodesis constructs were tested in 3‐point bending in a dorsal‐to‐palmar (plantar) direction using a materials‐testing machine. Loading rate was 19 mm/s. Maximal bending moment at failure and composite stiffness were obtained from bending moment—angular deformation curves. Data were analyzed using ANOVA and χ2 analysis.Results— There were no significant differences in bending moment (P > .05, power = 0.8 @δ= 19%) or composite stiffness (P > .05, power = 0.8 @δ= 19%) between the 2 fixation techniques. Higher maximal bending moment was found in front limbs than hind limbs, and front limbs with two 5.5‐mm screws than hind limbs with two 5.5‐mm screws. In all cases, constructs completely failed. A greater number of 4.5‐mm cortical screws failed than 5.5‐mm cortical screws.Conclusions— In pastern arthrodesis constructs loaded in 3‐point bending, end (front limb vs hind limb) affected maximal bending moment at failure of constructs. There was no significant effect of horse, treatment, or side on maximal bending moment or stiffness. Two 5.5‐mm cortical screws should provide a surgically simpler pastern arthrodesis than three 4.5‐mm cortical screws while maintaining similar biomechanical characteristics.Clinical Relevance— Three 4.5‐mm screws or two 5.5‐mm screws will provide similar biomechanical characteristics in bending when performing equine pastern arthrodesis.
Extra‐articular absorbable suture stabilization of coxofemoral luxation in dogs
Authors: Martini Filippo Maria , Simonazzi Barbara , Del Bue Maurizio 
Published: August 2002

Objective—To evaluate the effectiveness of an extra‐articular surgical technique using absorbable suture material for the stabilization of traumatic coxofemoral luxation in dogs.Study Design—Prospective, clinical study.Animals—Fourteen client‐owned dogs with recent and long‐standing traumatic coxofemoral luxation (13 craniodorsal and 1 ventral).Methods—Coxofemoral luxations were surgically reduced and maintained in place with an extra‐articular iliofemoral multifilamentous absorbable suture (3 to 6 strands of 2 USP Polyglactin 910). No external support was employed, and all the dogs were encouraged to use the affected limb postoperatively. The average time of clinical and radiographic follow‐up was 11.6 ± 6.3 months (from 2 to 22 months).Results—During the follow‐up period, no reluxations occurred and no complications associated with the surgical technique were identified. The dogs started bearing weight from 1 to 10 days after the surgery (mean, 4.3 ± 2.9 days) and the period of lameness ranged from 7 to 30 days (20 ± 8.6 days). At the final clinical examination, the dogs did not demonstrate any lameness or pain during passive flexo‐extension movements, and there was no significant limitation of the range of motion.Conclusions—Extra‐articular stabilization with multifilamentous absorbable sutures is a simple, effective method of treatment for acute and chronic coxofemoral luxation. The absorbable material used is strong enough to maintain articular stability during the period of scar tissue formation even in large‐breed dogs.Clinical Relevance—Absorbable sutures avoid the possible complications related to the use of nonabsorbable material and seem to be sufficient to maintain articular stability during the capsular healing process.
A dynamical model of Jupiter's auroral electrojet
Authors: Achilleos N , Miller S , Prangé R , Millward G , Dougherty M K 
Published: August 2002

A global simulation for the auroral electrojet on Jupiter is presented. The required sequence of models was computed using JIM (the Jovian Ionospheric Model), a time-dependent, three-dimensional model for the thermosphere and ionosphere of Jupiter, and ana priorimodel for the planet's ionospheric electric field. We describe the plasma dynamics in the model by considering ion and electron motions at pressure levels less than 2 µbar, lying above Jupiter's dynamo region, and including the region of maximum energy deposition by auroral particles.By considering the motions of the neutral species being `dragged' by the electrojet, we quantify the electrodynamic coupling between the neutral thermosphere and the auroral ionosphere. Two distinct altitude regions evolve in the model simulations, distinguished by different thermospheric flow patterns. Higher-altitude regions are subject to gas dynamic flow, while lower-altitude regions are strongly influenced by electrodynamic flow, associated with the transfer of momentum from the electrojet to the neutral gas. The electrojet models provide a basis for physical interpretation of current observational detections of ion motions in the Jovian auroral regions; as well as a means of optimizing future observations, in order to make similar detections.
Prenatal testosterone treatment potentiates the aggression‐inhibiting effect of the neurosteroid dehydroepiandrosterone in female mice
Authors: Perché Fabrice , Young Jacques , Robel Paul , Simon Neal G. , Haug Marc 
Published: August 2002

AbstractThe neurosteroid dehydroepiandrosterone (DHEA) is a powerful inhibitor of aggression in murine models when given for 15 days and potentially may be useful in the management of inappropriate human aggression. Although the biosynthesis and metabolism of DHEA have been described, little is known about the potential effect of the steroidal environment during sexual differentiation on the subsequent response to DHEA. Whether prenatal androgen exposure influences the subsequent response to DHEA was assessed by comparing the effect of DHEA (80 μg/d) on aggression in female offspring where dams were treated with 1, 10, or 100 μg of testosterone (T) on days 15 to 18 of gestation (Experiment I) or that developed in different uterine positions (Experiment II). The results showed that DHEA decreased attack behavior in general and that the 100‐μg prenatal T treatments enhanced the antiaggressive effect of this neurosteroid. Neither the lower doses of exogenously administered T nor the uterine position led to an enhanced response to DHEA. In addition, whether DHEA produced changes in social and nonsocial activities was examined. In the 100‐μg T females, DHEA increased the duration of the former and decreased the frequency and duration of the latter, indicating that it was not a general decrement in behavioral expression that mediated the enhanced response to the antiaggressive effect of DHEA. In the second experiment, DHEA treatment led to increased frequencies of social nonaggressive and nonsocial activities. However, the uterine positions × treatment interactions were not significant, demonstrating that contiguity to male fetuses did not differentially affect the response to DHEA. Aggr. Behav. 27:130–138, 2001. © 2001 Wiley‐Liss, Inc.
Predicting a moving object position for visual servoing: theory and experiments
Authors: Gortcheva E. , Garrido R. , González E. , Carvallo A. 
Published: August 2002

AbstractIn order to perform visual servoing tasks in a robotic system, one is confronted with the low sampling rate of standard cameras and the time delay introduced by image processing. One way to circumvent the time‐delay problem is to estimate future positions of the moving object of interest employing prediction techniques. In this work, three prediction techniques, namely Kalman filtering and two adaptive techniques employing least squares with forgetting factor and the projection algorithm, respectively, are evaluated in terms of their prediction error. Experimental results show that the adaptive techniques give best results and the Kalman filter‐based predictor shows a high sensitivity to velocity changes of the moving object. Copyright © 2001 John Wiley & Sons, Ltd.
Soluble angiogenic factors: Implications for chronic myeloproliferative disorders
Authors: Musolino C. , Calabro' L. , Bellomo G. , Martello F. , Loteta B. , Pezzano C. , Rizzo V. , Alonci A. 
Published: August 2002

AbstractThe role of angiogenesis for the progressive growth and metastatic process of tumours is well established. What is not clear, though, is the clinical prognostic significance of the angiogenic factors in malignant haematological diseases. In this study, we have assessed the plasma and serum levels of two major angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b‐FGF) in 55 patients affected by chronic myeloproliferative disorders (CMD). This series included 25 patients with essential thrombocythemia (ET), 10 patients with chronic myelocytic leukaemia (CML), 14 patients with polycythemia vera (PV), and 6 patients with primary myelofibrosis (MF), and they were compared to 20 healthy control subjects. In all patients the plasma VEGF concentration was significantly increased to the healthy control group (P < 0.004). The highest concentrations were found in the patients with ET (178.25 ± 125.22 pg/ml). The VEGF levels were significantly higher in CMD patients with vascular complications than those in CMD patients without complications (P < 0.01). The b‐FGF serum levels also appeared to be significantly higher in almost all the CMD patients compared to the control group (P < 0.07). A significant correlation was found between the VEGF levels and the platelet count in the ET patients and the spleen index in the CML patients. VEGF level, in this study, is associated with increased risk of thrombotic complications. There is evidence of increased levels of soluble angiogenic factors in malignant haematological disorders, but their contribution to the progression of diseases is yet unclear. Am. J. Hematol. 69:159–163, 2002. © 2002 Wiley‐Liss, Inc.
Inverse relationship between plasma von Willebrand factor and soluble P selectin in patients with type 1 but not type 2 von Willebrand disease
Authors: Blann A.D. , Nitu‐Whalley I.C. , Lee C.A. , Lip G.Y.H. 
Published: August 2002

AbstractP selectin is a component of endothelial Wiebel‐Palade body membrane and platelet alpha granule membrane. Patients with von Willebrand disease (VWD) have low plasma von Willebrand factor (VWF). To examine the relationship between plasma P selectin and VWF, both were measured by ELISA in 38 patients with VWD and 40 controls. The patient had lower VWF (P < 0.001) but similar P selectin levels (P = 0.458). In 24 type 1 VWD patients, VWF and P selectin correlated inversely (P = 0.005) but in 14 type 2 VWD patients there was no correlation (P = 0.997). These data imply major differences in VWF/P‐selectin regulation between types 1 and 2 VWD. Am. J. Hematol. 69:135–137, 2002.© 2002 Wiley‐Liss, Inc.
Burkitt's lymphoma of stomach: A case report and review of literature
Authors: Sharma Atul , Raina Vinod , Gujral Sumeet , Kumar Rajive , Tandon Rakesh , Jain Paresh 
Published: August 2002

AbstractPrimary gastrointestinal non‐Hodgkin's lymphoma is a distinct clinicopathological entity. This is the commonest site of all extranodal lymphomas. Non‐endemic Burkitt's lymphoma (high‐grade, small non‐cleaved lymphocytic type) is rare in non‐HIV adult population. We hereby report Burkitt's lymphoma of stomach in a non‐HIV adult. Gastric and lymph node biopsy confirmed the diagnosis. Patient was treated using a third generation chemotherapy protocol without any surgical resection. The patient relapsed within 3 months of completion of primary treatment and died of progressive disease. Am. J. Hematol. 67:48–50, 2001. © 2001 Wiley‐Liss, Inc.
Malignant mesothelioma in Australia, 1945–2000*
Authors: Leigh James , Davidson Patricia , Hendrie Leigh , Berry Dale 
Published: August 2002

AbstractBackgroundAustralia has maintained a total national malignant mesothelioma case register since 1980. There has been a marked increase in the incidence of mesothelioma in the last 20 years. Currently 450–600 cases are notified annually in a population of 20 million. While the history of the Wittenoom (Western Australia) crocidolite mine and its aftermath is well known, these cases comprise only 5% of the total. This study describes the incidence of mesothelioma in Australia from 1945 to 2000.MethodsUsing register data, time trends in mesothelioma incidence were calculated. Analyses of incidence are reported by age, sex, anatomical site, and state of notification. Associations with occupational and environmental asbestos exposure histories are described. Lung fiber content measurements were made on a subset of cases.ResultsAustralia has had 6,329 cases of mesothelioma from 1 January 1945 to 31 December 2000. (A further 620 cases were notified in the period from 1 January 2001 to 31 October 2001.) Annual incidence rates for Australia per million population ≥ 20 years (1997) were: male, 59.8; female, 10.9; total, 35.4. Incidence rates have been continually increasing and are the highest reported national rates in the world. While Western Australia has the highest rate (1997 total rate, 52.8), most cases arise from the two most populous eastern states, New South Wales and Victoria. In 88% (male 90%, female 61%) of cases, a history of asbestos exposure was obtained. Exposures occurred in a wide variety of occupational and environmental circumstances. In 80% of cases with no history of exposure, TEM lung asbestos fiber counts > 200,000 fibers > 2 μm length per gm dry lung were obtained, suggesting unrecognized exposure.ConclusionsAustralia's high incidence of mesothelioma is related to high past asbestos use, of all fiber types, in a wide variety of occupational and environmental settings. The number of cases in total is expected to be about 18,000 by 2020, with about 11,000 yet to appear. Am. J. Ind. Med. 41:188–201, 2002. © 2002 Wiley‐Liss, Inc.
Re: Malignant mesothelioma from neighborhood exposure to anthophyllite asbestos
Authors: Kottek Michael , Kilpatrick David 
Published: August 2002

AbstractWe read with interest the recent case report of mesothelioma associated with neighborhood exposure to anthophyllite asbestos [Rom et al., 2001], and a report of asbestosis from occult exposure to anthophyllite [Dodson and Levin, 2001]. However, we wish to correct Rom's assertion that anthophyllite was mined exclusively in Finland and Japan. Five hundred and ten tons of anthophyllite was mined in the Bindi Bindi area of Western Australia during the period 1942‐49 [Carter and Lipple, 1982]. The mining was largely open cast and the resulting ore was transported by railway to Perth, the capital city of Western Australia. The ore was then milled in a predominantly suburban area. The majority of the fiber produced was exported to unknown destinations, although some was used locally for boiler lagging, acid resistant filters and oil filters [Johnson, 1948]. It is not known what, if any, dust extraction system was in place at the mill. The current condition of the mine site is not known. However, the area surrounding the mine site was and remains a sparsely populated area and only a small population would be affected by any continuing environmental exposure.
Prader Willi/Angelman and DiGeorge/velocardiofacial syndrome deletions: Diagnosis by primed in situ labeling (PRINS)
Authors: Tharapel Avirachan T. , Kadandale Jayarama S. , Martens Paula R. , Wachtel Stephen S. , Wilroy R. Sid 
Published: August 2002

AbstractA recently developed methodology—primed in situ labeling (PRINS)—can be used in place of fluorescence in situ hybridization (FISH) to diagnose microdeletions. To demonstrate the efficiency, sensitivity, and specificity of PRINS in the diagnosis of microdeletions, we studied groups of patients with Prader Willi/Angelman (PWS/AS) syndrome and DiGeorge/velocardiofacial syndrome (DGS/VCFS). Results obtained by PRINS were then confirmed with the results obtained with FISH. Oligonucleotide primers specific for SNRPN and GABRB3 were used for PWS/AS syndromes. For DGS/VCFS, the primers used were DGCR2/TUPLE1 loci. Labeling patterns obtained by PRINS and FISH were analyzed and scored under a fluorescence microscope. Five normal subjects served as controls and were used for standardization of the PRINS protocol. In all, 20 study patients were involved: 10 PWS/AS and 10 DGS/VCFS. Five of the 10 patients referred with the clinical diagnosis of PWS/AS showed absence of labeling for SNRPN and GABRB3 on one chromosome 15, confirming deletion of the two loci. Similarly, 6 of the 10 patients referred for DGS/VCFS showed deletion for the DGCR2/TUPLE1 loci on one chromosome 22. The remaining patients and controls had normal patterns for all the loci as indicated by FISH and PRINS. Concordant FISH and PRINS results were obtained in all patients and controls studied. © 2001 Wiley‐Liss, Inc.
Application of robust pedigree analysis in studies of complex genotype–phenotype relationships in fragile X syndrome
Authors: Loesch D.Z. , Huggins R.M. , Taylor A.K. 
Published: August 2002

AbstractRelationships between the fragile X dynamic mutation and palmar and finger epidermal ridge measures were assessed using a robust modification of the maximum likelihood estimators for pedigree data. A total of 34 extended families affected with fragile X syndrome were used. Phenotypic traits included ridge count on the thumb and ridge breadth measured in the second palmar interdigital area bilaterally. Genotypic measures were represented by the number of CGG repeats in the FMR1 gene, the levels of specific FMR1 protein (FMRP), fragile X category defined by the size of the CCG repeat, and methylation status of the gene. The results demonstrated a significant fragile X effect (related to the number of CGG repeats) in the thumb ridge count in males. This effect was more evident in ridge breadth and was found in both sexes. However, the relationship between both phenotypic traits and the level of FMRP was nonsignificant. The study makes a useful contribution to the development of methodologies for the analysis of genotype–phenotype relationships in dynamic mutations, especially in overcoming extensive variability in both the genotype and phenotype, and in approaching the statistical problems related to intergenerational changes in repeat size. The findings support the hypothesis that the fragile X mutation affects limb development during an early fetal period. © 2001 Wiley‐Liss, Inc.
Possible association of NTDs with a polyhistidine tract polymorphism in the ZIC2 gene
Authors: Brown Lúcia Y. , Hodge Susan E. , Johnson William G. , Guy Sandra G. , Nye Jeffrey S. , Brown Stephen 
Published: August 2002

AbstractNeural tube defects (NTDs) and brain malformations represent a common finding in chromosome 13q deletion patients. Hemizygosity for ZIC2, which is located in the 13q32 critical deletion region, results in holoprosencephaly (HPE) in humans, and diminished expression of ZIC2 results in HPE as well as lumbosacral NTDs in mice. Taken together, these observations led us to hypothesize that ZIC2 mutations may be a cause of isolated NTD. To test this, we screened 192 NTD patients for mutations in ZIC2. While we did not find ZIC2 mutations in these patients, we did find some evidence of a possible association between a histidine tract polymorphism in ZIC2 and NTDs. Our sample was too small to reach definitive conclusions, but the evidence is sufficiently intriguing to encourage further research. If this association is confirmed, subtle alterations in ZIC2 activity may confer a risk of NTD. © 2002 Wiley‐Liss, Inc.