bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of maxillary asymmetry before and after treatment of functional posterior cross-bite: a retrospective study using 3D imaging system and deviation analysis
Authors: Ronsivalle Vincenzo , Isola Gaetano , Lo Re Gianmarco , Boato Mattia , Leonardi Rosalia , Lo Giudice Antonino 
Published: December 2023

Abstract
Background
Previous evidence would suggest that subjects affected by functional posterior cross-bite (FPXB) present an asymmetric morphology of the maxilla. However, no evidence is available concerning the morphology (symmetry/asymmetry) of the maxilla after treatment of FPXB. This study aimed to investigate the volumetric and morphological changes of the palate in FPXB subjects treated with maxillary expansion and to compare these data with an untreated control group. The study sample included 20 FPXB subjects (mean age 8.1 ± 0.9 years) who underwent maxillary expansion (MEG group) and 21 FPXB subjects (mean age 7.7 ± 1.2 years) as controls (CG group). Digital models were recorded at T0 (first observation) and T1 (12–18 months after first observation) and analyzed to assess palatal volume and symmetry. Deviation analysis and percentage matching calculation were also performed between original and mirrored palatal models for each patient. All data were statistically analyzed for intra-timing, inter-timing and inter-groups assessments.

Results
At T0, the cross-bite side (CBS) was significantly smaller than non-cross-bite side (non-CBS) in both groups (p < 0.05). At T1, the CBS/non-CBS difference reduced significantly in the MEG group (p < 0.05) while slightly worsened in the CG, however without statistical significance (p > 0.05). The matching percentage of the palatal models improved significantly at T1 in the MEG group (T0 = 74.02% ± 9.8; T1 = 89.95% ± 7.12) (p < 0.05) while no significant differences were recorded in the CG (T0 = 76.36 ± 8.64; 72.18% ± 9.65) (p > 0.05).

Limitations
The small sample size and the retrospective design of the study represent two limitations that should be overcome with further clinical trials.

Conclusions
Subjects with FPXB present an asymmetric development of the maxillary vault that improves after reestablishment of normal occlusion following maxillary expansion.
Muscle ultrasound shear wave elastography for detection of early onset lower limb ischemia in patients with veno-arterial extracorporeal membrane oxygenation
Authors: Maslarska Mariya , Piepenburg Sven , Westermann Dirk , Supady Alexander , Hehrlein Christoph 
Published: December 2023

Abstract
Background and objectives
Limb ischemia or compartment syndrome, requiring surgery, are some of the frequent cannula-related complications in patients supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). The purpose of this exploratory study is to depict and evaluate the dynamic changes in the lower limb muscles with ultrasound shear wave elastography as marker for early lower limb ischemia.

Methods
Eleven patients with VA-ECMO after cardiac arrest were included in this study. Seven patients received distal perfusion cannula (DPC) after implantation of the VA-ECMO, whereas 4 had no DPC after VA-ECMO. Compartment syndrome was clinically excluded in all patients. Both lower limbs, e.g., with and without arterial cannula, were monitored with near-infrared spectroscopy (NIRS) for the oxygen saturation of the local tissue. We performed ultrasound shear wave elastrography (SWE) to assess dynamic changes of the medial gastrocnemius muscle at maximum passive muscle stretch (exercise) of both legs. Color-coded duplexsonography was conducted to examine the blood flow velocity of the popliteal artery of the lower limb.

Results
We found no difference between DPC and no DPC (p = 0.115) during use of VA-ECMO. However, we detected marked lower limb muscle perfusion deficits of cannulated (58.9 ± 13.5 kPa) vs. cannula-free limb (95.7 ± 27.9 kPa: p < 0.001), applying SWE. No relationship was detected between NIRS measurements and SWE values (kPa) of both lower limbs. The mean peak systolic velocity of the popliteal artery at the cannulated side (30.0 ± 11.7 cm/s) was reduced compared to the non-cannulated side (39.3 ± 18.6 cm/s; p = 0.054).

Conclusions
Regardless of DPC after implantation of VA-ECMO, the gastrocnemius muscles seem to lose function due to cannula-related microcirculatory deficits. Muscle function analysis via SWE combined with NIRS might offer a sensitive indicator for early onset leg ischemia during VA-ECMO-related arterial cannulation.
Opening up ideas: an advent calendar for patient and public engagement in clinical trials research
Authors: Harman Nicola L. , McGiveron Kerrie , Tudur Smith Catrin , Williamson Paula R. , Barrington Heather 
Published: December 2023

AbstractThe involvement of patients and the public in research is now an expectation in research with funders requesting a clear plan of involvement and engagement. In the United Kingdom involvement typically focuses on research prioritisation, design and delivery, in contrast activities that share the results of research or research methods more generally are considered to be engagement. Clinical trials tend to concentrate on involvement activities with less emphasis on engagement. To promote engagement activities in the context of clinical trials we asked people attending the 2022 International Clinical Trials Methodology Conference to share ideas on how we can best engage with patients and the public. Responses were reviewed and 22 themes identified. One suggestion was to create an advent calendar and so these 22 themes plus two from the authors were used as a daily tweet from the 1st to the 24th December 2022. Here we share these ideas and draw comparisons between engagement activities in research and traditions of the Christmas period. The ideas shared are not intended as a definitive list but instead a novel way to start discussions between experts by experience, researchers, health professionals and communities to facilitate co-production of meaningful engagement strategies.
99mTc-DMSA renal cortical scanning: a comparison of planar, SPECT, and SPECT/CT imaging for the detection of renal cortical scarring
Authors: Mohamadien Nsreen R. A. , Mohamed Marwa S. , Mekkaway Mohamed A. , Ali Wageeh A. , Diab Waleed A. 
Published: December 2023

Abstract
Background
The best way to assess renal cortical scarring is planar scintigraphy with 99mTc-dimercaptosuccinic acid (DMSA), while the value of single-photon emission computed tomography/computed tomography (SPECT/CT) is not well validated. The aim of the present study was to assess the value of planar, SPECT, and SPECT/CT scanning using 99mTc-DMSA in detecting renal cortical scarring.

Methods
Patients with clinically suspected renal cortical scar were included in this prospective cohort. 99mTc-DMSA Planar images were obtained approximately 3–4 h after intravenous injection (IV) of 185 MBq of the tracer. SPECT/CT scans were obtained immediately after the planar ones. An expert nuclear medicine doctor who was unaware of the patient's clinical history or any previous imaging results analyzed the images. Each kidney was given a score of 0 for no obvious defects, 1 for equivocal lesions, 2 for a single defect, 3 for several defects, and 4 for non-visualized/non-functioning kidney (in CT images). The results of each method were then compared to each other.

Results
One hundred eighty-six kidneys from ninety-three individuals were eligible for assessment. Planar scans detected 21 kidneys with equivocal lesions, 5 with single and 7 with multiple defects. SPECT scans detected 17 kidneys with single and 40 with multiple defects, while SPECT/CT scans revealed 5 with single and 11 with multiple defects. Only 5 of the 17 kidneys with single defects diagnosed by SPECT imaging had a scar in the SPECT/CT scans, whereas the remaining 12 had a solitary cortical cyst in the CT images. Only 11 of 40 kidneys with multiple defects on SPECT were shown to have a scar in the corresponding SPECT/CT images, whereas the rest matched to either hydro-nephrotic changes or multiple cortical cysts. Four kidneys with multiple defects on the SPECT/CT images were normal in the planar readings, were ascribed to an increase in renal background activity and a reduction in renal function.

Conclusions
In cases with suspected renal cortical scar, 99mTc-DMSA SPECT/CT scanning outperformed both planar and SPECT imaging by reducing the number of false-positive SPECT readings and false-negative planar readings.
GC–MS and ADME profile analysis of Carcinoscorpius rotundicauda bioactive compounds and their potential as COVID-19 antiviral
Authors: Sururi Ahmad Misbakhus , Rahayu Dwi Anggorowati , Rohma Martina Kurnia , Faizah Maftukhatul , Vebianawati Elsa Aulia , Savita Mia 
Published: December 2023

Abstract
Background
Carcinoscorpius rotundicauda is a species of horseshoe crab that is rarely studied. This animal is often used as part of the blood as a medical sterilization material. This study aims to identify the content of bioactive compounds and their bioactivity as an antiviral for COVID-19. The stages of this research include extraction, GC–MS analysis, molecular docking analysis, and ADME analysis.

Results
The results showed that in the ethyl acetate extract of the meat, there were 13 bioactive compounds with dominant compound which is propanoic acid (32.15%). Based on molecular docking, one potential compound was found as an antiviral for COVID-19 ACE2, 3CLpro, and RdRp inhibitor, namely 2-methyl-5-(4′-methyl phenyl)sulfonyl-4-nitroimidazole. The druglikeness and ADME compound profile shows support as an excellent oral drug compound.

Conclusions
Carcinoscorpius rotundicauda has potential as an inhibitor of ACE2, RdRp, and 3CLpro receptor as an anti-SARS-CoV-2. Further research, such as in vitro and in vivo, is still needed to develop its potential as a COVID-19 antiviral.
Über den Spuren der Anderen: Ausgrabungen zur Fernwärmeleitung im Jahr 2022
Authors: Graber Simon , Hodel Corinne , Martin Erik , Savary Johann , Schmidig Roman , Wyss Benedikt 
Published: December 2023

Wie ein dichtes Netz durchziehen die neuen Fernwärmleitungen den Untergrund Basels. Sie gewähren über weite Strecken einen einmaligen Einblick in die Geschichte der Stadt. Auch im Jahr 2022 haben deshalb drei Teams der Archäologischen Bodenforschung die umfassenden Bauarbeiten begleitet. Auf einem Spaziergang führen die Archäolog:innen zu den wichtigsten Entdeckungen.
Am Marktplatz und in der Freien Strasse wurden zahlreiche ältere Pflästerungen, eine römische Spolie und Reste der früheren Bebauungen entdeckt. Funde, die im Brandschutt eines Kellers freigelegt wurden, erlauben wichtige Erkenntnisse zum handwerklichen Kontext und dem Alltag im Spätmittelalter. Weiter geht es durch die St. Alban-Vorstadt zu 2000 Jahre alten Karren- und Fussspuren sowie Gräbern, die zum mittelalterlichen Kloster gehörten. Jenseits des Rheins gelangt man zum römischen Befestigungsgraben und frühmittelalterlichen Bestattungen im Wettsteinquartier. Die Gräber lassen den Wohlstand und die überregionalen Beziehungen der Reichen im späten Frühmittelalter erahnen, zeugen aber auch vom Leid durch brutale Gewalt.
Viviendas de bóveda catenaria en la sierra de Guadarrama durante la Guerra Civil española
Authors: Arévalo Molina Jacinto M , Schnell Quiertant Pablo 
Published: December 2023

Durante la Guerra Civil Española se planteó la necesidad de construir alojamientos invernales para los combatientes en la sierra de Guadarrama que sustituyesen a las chabolas empleadas hasta entonces. Se ensayaron diversas soluciones, como viviendas con techo plano, cuarteles blindados o barracones de diversos tipos. Avanzado 1937 en el frente guarnecido por la división 72ª del ejército nacional aparecen unas viviendas específicas cubiertas con bóveda catenaria. Eran versátiles, fáciles y rápidas de construir y en caso de necesidad podían blindarse convirtiéndose en abrigos a prueba o nidos de ametralladora. Se hicieron con relativa abundancia en ese sector del frente y parece que no tuvieron continuidad acabada la guerra. El conocimiento que tenemos de ellas es escaso, más allá de su mera enumeración en la bibliografía y algún artículo específico de época. Lo que sabemos deriva principalmente de la información obtenida del estudio de sus restos y algunos documentos de archivo.
Ultrasound-guided medial branch of the superior laryngeal nerve block to reduce peri-operative opioids dosage and accelerate patient recovery
Authors: Kang Qiuxiang , Wu Liang , Liu Yaohong , Zhang Xu 
Published: December 2023

Background
To explore whether the medial branch block of superior laryngeal nerve can reduce the stress response of patients undergoing intubation and further reduce the dosage of opioids.

Methods
80 patients undergoing gynecological laparoscopic surgery were selected, and randomly divided into 4 groups. All patients in the experimental groups received bilateral internal branch of superior laryngeal nerve block and transversus abdominis plane block. But the dosage of sufentanil used for anesthesia induction in the group A, B, and C was 0.4, 0.2, and 0μg/kg, respectively. Group D do not underwent supralaryngeal nerve block and the dosage of sufentanil was 0.4μg/kg. The heart rate (HR) and mean arterial pressure(MAP) were recorded at the time of entering the operating room(T1), before intubation after induction(T2), immediately after intubation(T3), 5min after intubation(T4), before extubation(T5), immediately after extubation(T6), 5min after extubation(T7). We also recorded the stay time in the recovery room, the number of cases of postoperative sore throat, the number of cases of nausea and vomiting, the first intestinal exhaust time, the length of hospital stay after operation.

Results
The HR of group A, C and D at T3 was significantly higher than that at T2(P < 0.01), while the HR of group B had no significant change. The HR of group A, C and D at T4 was lower than that at T3(P < 0.01), while the HR of group B had no obvious change. The HR of group C and D at T3 was significantly higher than that at T1 (P < 0.01). The MAP of group A and D at T4 was significantly lower than that at T1 (P<0.001). The first postoperative intestinal exhaust time in group A, B and C was significantly shorter than that in group D. The length of hospital stay after operation in group B and C was shorter than that in group D.

Conclusions
Ultrasound-guided superior laryngeal nerve block combined with 0.2μg/kg sufentanil can reduce the intubation reaction, have better hemodynamic stability, reduce the first postoperative intestinal exhaust time and postoperative hospital stay, thereby accelerating the postoperative recovery of patients.
A scoping review on the psychosocial interventions used in day care service for people living with dementia
Authors: Tuohy Dympna , Kingston Liz , Carey Eileen , Graham Margaret , Dore Liz , Doody Owen 
Published: December 2023

Background
Adult Day care centres provide an important aspect of care provision through all phases of the dementia illness from diagnosis to the end of life (Dabelko HI 2008) supporting the well-being of both older people living with dementia and their care partners. Services within adult day care settings are designed to provide biopsychosocial health benefits to participants as well as care partner respite.

Objective
To examine research studies, literature reviews and grey literature and identify and map the literature on psychosocial interventions used in day care services for older people living with dementia and chart their use, evaluation and outcomes. The research review question is “what are the psychosocial interventions used in day care service for older people living with dementia?” Psychosocial interventions are important non-pharmacological interventions which support people’s wellbeing.

Methods
Inclusion/Exclusion criteria were identified and guided the search strategy. Participants were people aged 60 years and over living with dementia attending day care services. The use of psychosocial interventions for this cohort was the focus of the review. Databases were searched (Cochrane Reviews, CINAHL, Embase, Medline EBSCO, Medline Ovid, Medline PubMed, PsycINFO, Scopus, Open Grey, Lenus and WHO Global Index Medicus databases) using keywords/terms with Boolean operators from 2011 to 2023. Rayyan was used to extract and manage the data.

Results
The findings present a narrative and charting of the data from the 45 papers that met the review criteria, and this data is mapped onto the five objectives. Within this review, interventions were grouped into five broad types: nature (n = 6 papers), memory/cognitive (n = 11 papers), social (n = 17 papers), animal (n = 4 papers), or physical/sensory (n = 7 papers) based interventions.

Conclusions
This review has illustrated the wide variety in the types, range and facilitation of psychosocial interventions within adult day care services. This review highlights the potential benefits of these interventions. However, findings must be considered in the context that many were provided as brief intervention studies with little evidence of continuation after the study and further research is required given the complex and diverse range of interventions. Results will be of interest to practitioners planning to implement or evaluate psychosocial interventions used in day care services for older people living with dementia.
Effect of screw angulation and multiple insertions on load-to-failure of polyaxial locking system
Authors: Glowacki Jakub , Bartkowiak Tomasz , Paczos Piotr , Mietlinski Patryk , Zawadzki Pawel , Lapaj Lukasz 
Published: December 2023

Purpose
Polyaxial locking plates rely on the alignment between the thread-to-thread connections of the screw head and the plate hole. These implants have provided substantial support for surgeons. In particular, extended screw positioning have proven to be beneficial in the fixation of challenging fractures. This study aimed to investigate the mechanical properties of ChM 5.0 ChLP polyaxial screws inserted in off-axis trajectories, including multiple insertions and to correlate these parameters with the screw head and the plate hole thread-to-thread engagement.

Methods
Polyaxial locking screws were inserted into the plates at various angles (0°,10°,15°, -15° off-axis). Multiple time inserted screws were placed firstly at 15°, then 0° and finally -15° off-axis in the same plate hole. A microCT scan of the plate-hole and screw-head interface was conducted before destructive tests. Representative screws from each group were also examined by Scanning Electron Microscope.

Results
The standard insertion at 0° sustained the greatest maximum bending strength without relocation in the screw hole. Screws inserted at 10° and 15° (one time) showed a significant reduction in load-to-failure of up to 36% and 55%, (p = 0.001) (p = 0.001) respectively. Screws inserted at -15° after a maximum of three multiple insertions with angle shift, showed a total reduction in force of up to 70% (p = 0.001). A microCT analysis of thread engagement showed significant correlations. However, the results obtained for multiple insertions were highly variable.

Conclusions
ChM 5.0 ChLP polyaxial locking system has valuable properties that foster fracture fixation, providing various surgical options. Nevertheless, the freedom of off-axis placement and multiple insertions of the screws comes at the price of reduced force. When possible surgeons should minimize the angles of insertions.
A non-socially-sensitive predictive model of prostate cancer for Asian males with benign prostatic hyperplasia: A multi-site cross-sectional case-control study
Authors: Chang Heng-Jui , Moi Sin-Hua , Chan Yu-Jiun , Lan Tzuo-Yun 
Published: December 2023

Background
Benign prostatic hyperplasia (BPH) is common in aging Asian males and is associated with an excess risk of developing prostate cancer (PCa). However, discussions about socially-sensitive experiences such as sexual activity, which can significantly predict PCa risk, may be considered stigmatized in Asian culture. This study aimed to develop a predictive model for PCa risk in Asian males with BPH using non-socially-sensitive information.

Methods
A cross-sectional case-control study, with PCa patients as the cases and remaining as the controls, was conducted on a cohort of Taiwanese males with BPH from four medical institutions. Patients who met the inclusion criteria were enrolled, excluding those aged over 86 years or who had received human papillomavirus (HPV) vaccination. Non-socially-sensitive variables such as obesity, occupational exposure, HPV infection, and PCa family history score (FH score) were included in a fully adjusted logistic regression model, and depicted using a nomogram.

Results
Among 236 BPH patients, 45.3% had PCa. Obesity, occupational exposure, HPV infection, and family history of PCa were significantly associated with PCa risk. The FH score (OR = 1.89, 95% CI = 1.03–3.47, P = 0.041) had the highest impact, followed by HPV infection (OR = 1.47, 95% CI = 1.03–2.11, P = 0.034), occupational exposure (OR = 1.32, 95% CI = 1.15–1.51, P <0.001), and obesity (OR = 1.22, 95% CI = 1.07–1.41, P = 0.005). The nomogram accurately depicted the predictive risk, and the model demonstrated robust performance compared to individual factors. In addition, the subgroup analysis results showed elderly age group could obtain more favorable predictive performance in our proposed model (AUC = 0.712).

Conclusion
This non-socially-sensitive predictive model for PCa risk in Taiwanese males with BPH integrates multiple factors that could provide acceptable PCa risk-predictive performance, especially for elderly BPH patients over 70 years, aiding clinical decision-making and early cancer detection.
ASSESSING THE IMPACT OF COVID-19 AND SANCTIONS ON THE ALTAI ECONOMY: A RECESSIONARY PERSPECTIVE
Authors: Borodin V. A. , Borodin V. D 
Published: December 2023

In recent years, the crisis in the domestic economy, caused by COVID-19 (2019-2020) and the tightening of sanctions imposed by the US government, EU countries, and others, has affected the Russian economy and the economy and social sphere of the Altai Territory. This article aims to identify the dynamics of the region’s economic performance and critical parameters of the social sphere from 2017 to 2022, assess the state of the situation, and make short-term forecasts for its development.
The crisis of the domestic economy in recent years, caused by the COVID-19 (2019-2020) and the tightening of the sanctions imposed by the USA government, EU countries and some others, could not but affect the Russian economy, in particular the economy and social sphere of the Altai Territory. In this article, the authors made an attempt, based on the economic performance of the industries of the region and the critical parameters of the social sphere, to identity the dynamics in the period 2017-2022, to assess the state and short-team forecasts for the development of the situation.
The authors suggest that the way out of the recession is possible through an increase in innovative activity among industrial enterprises, implementation of an import substitution program, development of consumer goods production through investment, and the attraction of savings from the population. By implementing these measures, the authors believe that the Altai economy can recover and improve in the future.