bluuebunny/crossref_metadata_2025_split huggingface dataset:
Onset patterns and clinical features of binge‐eating disorder in a Japanese clinical sample
Authors: Nakai Yoshikatsu , Nin Kazuko , Noma Shun'ichi , Teramukai Satoshi 
Published: January 2024

AbstractObjectiveThis study aimed to investigate the clinical presentation of binge‐eating disorder (BED) in a Japanese sample and to examine the relationship between subtypes of BED differing in onset patterns and those differing in prior history of another eating disorder (ED).MethodsThe study participants were 137 adults who met the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5) criteria for BED. We subtyped participants based on prior history of another ED: 55 (40.1%) participants with a history of another ED (BED ED+) and 82 participants without such a history (BED ED–).ResultsUnlike in some Western studies, approximately three quarters of participants had a body mass index of <25 kg/m2. None of the participants reported a history of another ED with purging or excessive exercise. All BED ED+ participants transitioned to BED from anorexia nervosa restricting type (AN‐R) or from atypical AN‐R. BED ED+ participants reported more severe psychopathology than BED ED‐participants. Only 20% had a treatment history for BED. Dieting preceded their first binge eating in 55 participants (DIET‐first BED), and binge eating preceded their first dieting in 82 participants (BINGE‐first BED). Regarding the relationship between the two different subtypes, all DIET‐first BED participants were in the BED ED+ group, whereas all BINGE‐first BED participants were in the BED ED‐group.DiscussionPresent findings revealed the clinical presentation of BED in a Japan‐based study and suggested that subtypes of BED differing in the prior history of another ED yielded an accurate prediction of onset patterns (dieting first vs. binge eating first).Public SignificanceThis study highlights the need for clinicians to consider subtype differences in onset patterns and clinical features of BED to treat and prevent this disorder. This study revealed that, although individuals with BED in Japan have severe symptoms and a long duration of illness, only 20% have received BED treatment. The results indicate a need to disseminate knowledge about BED to the Japanese public and healthcare providers.
Planar Chiral Ferrocendiyl and Ruthenocendiyl Bisimidazoline Bispalladacycles Featuring Pyridin‐2‐olates and Ketophenolates as Potentially Hemilabile Ligands in Asymmetric 1,4‐Additions
Authors: Dorst Konstantin , Frey Wolfgang , Peters René 
Published: January 2024

AbstractPlanar chiral bispalladacycles based on ferrocene have previously been shown to be excellent catalysts for asymmetric 1,4‐additions of α‐cyanoacetates to enones. For a bimetallic reaction pathway, it was found that product decomplexation is probably rate‐determining as a result of a bimetallic two‐point binding. We hypothesized that the use of hemilabile chelating ligands might accelerate this step to improve the catalytic activity. Here we report the use of pyridin‐2‐olates (pyridonates) as potentially hemilabile 1,3‐N,O‐chelating ligands in this catalytic application. In this article, we describe the first coordination of pyridonate ligands to planar chiral, metallocene based palladacycles. Four of the resulting ferrocene and ruthenocene bis‐palladium complexes were characterized by X‐ray single crystal structure analysis revealing a μ2‐(O,N) coordination mode. We suggest that an observed lower catalytic efficiency of the new complexes has its origin in this particular coordination mode. For that reason, a related trifluoromethylketophenolate ligand was installed for which κ2‐(O,N) coordination was expected and also experimentally found. Indeed, in that case catalytic activity was improved compared to the benchmark system.
Comprehensive Photophysical and Nonlinear Spectroscopic Study of Thioanisolyl‐Picolinate Triazacyclononane Lanthanide Complexes
Authors: Akl Dina , Bridou Lucile , Hojorat Maher , Micouin Guillaume , Kiraev Salauat R. , Riobé François , Denis‐Quanquin Sandrine , Banyasz Akos , Maury Olivier 
Published: January 2024

AbstractDetailed photophysical studies of luminescent lanthanide complexes are presented and elaborated using a newly developed thioanisolyl‐picolinate antenna and the related tacn macrocyclic ligand. The new ligand proved to sensitise Nd(III), Sm(III), Eu(III) and Yb(III) emission. Eu(III) complex showed complete energy transfer, yielding high quantum yield (44 %) and brightness, while the Tb(III) analogue underwent a thermally activated back‐energy transfer, resulting in a strong oxygen quenching of the triplet excited state. Transient absorption spectroscopy measurements of Gd(III), Tb(III) and Eu(III) compounds confirmed the sensitization processes upon the charge‐transfer antenna excitation. The triplet excited state lifetime of the Tb(III) complex was 5‐times longer than that of the Gd(III) analogue. In contrast, the triplet state was totally quenched by the energy transfer to the 4f‐metal ion in the Eu(III) species. Nonlinear two‐photon absorption highlighted efficient biphotonic sensitization in Eu(III) and Sm(III) complexes. In case of the Nd(III) compound, one‐photon absorption in 4f–4f transitions was predominant, despite the excitation at the antenna two‐photon band. This phenomenon was due to the Nd(III) 4f–4f transitions overlapping with the wavelength‐doubled absorption of the complex.
Investigation of the effects of white tea on liver fibrosis: An experimental animal model
Authors: Yılmaz Hülya Kılıç , Türker Merve , Kutlu Eda Yılmaz , Mercantepe Tolga , Pınarbaş Esra , Tümkaya Levent , Atak Mehtap 
Published: January 2024

AbstractLiver fibrosis is a common, progressive disease that affects millions of patients worldwide. In this study, it was aimed at investigating the effect of white tea on liver fibrosis in an in‐vivo environment by creating an experimental liver fibrosis model on rats. In this study, an experimental liver fibrosis model was created with carbon tetrachloride (CCl4) in Sprague–Dawley rats to investigate the effect of white tea on liver fibrosis. Rats are treated with CCl4 (1 mL/kg) to constitute the liver fibrosis model. White tea was given ad libitum with drinking water. As a result of the study, liver tissue hydroxyproline levels were found to be significantly lower (p = .001) in the white tea group. Histopathologically, it was found that the liver tissue histopathological damage score (LHDS) and fibrosis scoring were significantly lower (p < .001) in the white tea group. However, although it was not statistically significant in the group given white tea, compared with the fibrosis group, it was found that the malondialdehyde (MDA) level in the liver tissues was lower, the glutathione (GSH) level was higher, and the serum alanine aminotransferase (ALT) levels were lower. The study explained the effect of white tea on liver fibrosis and suggested that white tea might be beneficial in reducing the progression of liver fibrosis.
Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review
Authors: Aryal Dipa , Joshi Soniya , Thapa Nabin Kumar , Chaudhary Pratiksha , Basaula Sirjana , Joshi Usha , Bhandari Damodar , Rogers Hannah M. , Bhattarai Salyan , Sharma Khaga Raj , Regmi Bishnu P. , Parajuli Niranjan 
Published: January 2024

AbstractIn the middle of an ever‐changing landscape of diabetes care, precision medicine, and lifestyle therapies are becoming increasingly important. Dietary polyphenols are like hidden allies found in our everyday meals. These biomolecules, found commonly in fruits, vegetables, and various plant‐based sources, hold revolutionary potential within their molecular structure in the way we approach diabetes and its intimidating consequences. There are currently numerous types of diabetes medications, but they are not appropriate for all patients due to limitations in dosages, side effects, drug resistance, a lack of efficacy, and ethnicity. Currently, there has been increased interest in practicing herbal remedies to manage diabetes and its related complications. This article aims to summarize the potential of dietary polyphenols as a foundation in the treatment of diabetes and its associated consequences. We found that most polyphenols inhibit enzymes linked to diabetes. This review outlines the potential benefits of selected molecules, including kaempferol, catechins, rosmarinic acid, apigenin, chlorogenic acid, and caffeic acid, in managing diabetes mellitus as these compounds have exhibited promising results in in vitro, in vivo, in silico, and some preclinical trials study. This encompassing exploration reveals the multifaceted impact of polyphenols not only in mitigating diabetes but also in addressing associated conditions like inflammation, obesity, and even cancer. Their mechanisms involve antioxidant functions, immune modulation, and proinflammatory enzyme regulation. Furthermore, these molecules exhibit anti‐tumor activities, influence cellular pathways, and activate AMPK pathways, offering a less toxic, cost‐effective, and sustainable approach to addressing diabetes and its complications.
Long‐term CO2 sequestration mechanisms and influence of injection mode in Zhujiang Formation of Pearl River Mouth Basin
Authors: Xuan Tao , Cao Xiaomin , Li Qi , Li Fangfang , Xu Liang 
Published: January 2024

AbstractIn this paper, the mechanisms of long‐term CO2 sequestration and the effects of injection modes (including injection temperature, injection rate and injection cycle) in Zhujiang Formation characterized by high porosity and permeability were investigated using the numerical simulation method. Simulation results showed that more than 88% of the injected CO2 would exist in a supercritical state during the injection period and more than 79% of CO2 would be sequestrated in the reservoir by mineral trapping after 5,000 years. Eventually, the distribution shape of SC‐CO2 was a quarter funnel near the injection well, while the distribution shapes of dissolved and mineralized CO2 were both one quarter rotunda. During the long‐term CO2 sequestration in Zhujiang Formation, the dissolved minerals were anorthite, chlorite and smectite in turn, while the top three main precipitated minerals were calcite, dawsonite and albite. Moreover, higher injection temperature leads to a higher mineral tapping and more dissolved/precipitated minerals. While higher injection rate reduces the mineral tapping and total amount of dissolved/precipitated mineral. Compared to injection temperature and injection rate, the injection cycle has little effect on the CO2 phase evolution and mineral dissolution/precipitation process. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd.
Crystal reconstruction of V2O3/carbon heterointerfaces via anodic hydration for ultrafast and reversible Mg‐ion battery cathodes
Authors: Jang Gun , Joe Yun Sang , Lee Sang Joon , Cho Hyun Gyu , Baek Sang Ha , Xiong Peixun , Shin Kang Ho , Yeon Jeong Seok , Kang Min Su , Oh Si Hyoung , Park Ho Seok 
Published: January 2024

AbstractMagnesium‐ion batteries (MIBs) have promising applications because of their high theoretical capacity and the natural abundance of magnesium Mg. However, the kinetic performance and cyclic stability of cathode materials are limited by the strong interactions between Mg ions and the crystal lattice. Here, we demonstrate the unique Mg2+‐ion storage mechanism of a hierarchical accordion‐like vanadium oxide/carbon heterointerface (V2O3@C), where the V2O3 crystalline structure is reconstructed into a MgV3O7∙H2O phase through an anodic hydration reaction upon first cycle, for the improved kinetic and cyclic performances. As verified by in situ/ex situ spectroscopic and electrochemical analyses, the fast charge transfer kinetics of the V2O3@C cathode were due to the crystal‐reconstruction and chemically coupled heterointerface. The V2O3@C demonstrated an ultrahigh rate capacity of 130.4 mAh g−1 at 50 000 mA g−1 and 1000 cycles, achieving a Coulombic efficiency of 99.6%. The high capacity of 381.0 mA h g−1 can be attributed to the reversible Mg2+‐ion intercalation mechanism observed in the MgV3O7∙H2O phase using a 0.3 M Mg(TFSI)2/ACN(H2O) electrolyte. Additionally, within the voltage range of 2.25 V versus Mg/Mg2+, the V2O3@C exhibited a capacity of 245.1 mAh g−1 when evaluated with magnesium metal in a 0.3 M Mg(TFSI)2 + 0.25 M MgCl2/DME electrolyte. These research findings have important implications for understanding the relationship between the Mg‐ion storage mechanism and reconstructed crystal phase of vanadium oxides as well as the heterointerface reconstruction for the rational design of MIB cathode materials.image
Population Pharmacokinetics of Nirsevimab in Preterm and Term Infants
Authors: Clegg Lindsay , Freshwater Ed , Leach Amanda , Villafana Tonya , Hamrén Ulrika Wählby 
Published: January 2024

AbstractNirsevimab, a monoclonal antibody with an extended half‐life, is approved for the prevention of respiratory syncytial virus (RSV) disease in all infants in Canada, the EU, Great Britain, and the USA. A population pharmacokinetics (PK) model was built to describe the PK of nirsevimab in preterm and term infants, and to evaluate the influence of covariates, including body weight and age, in infants. Nirsevimab PK was characterized by a 2‐compartment model with first‐order clearance (CL) and first‐order absorption following intramuscular (IM) administration. The typical CL in a 5 kg infant was 3.4 mL/day. Body weight and postmenstrual age were the primary covariates on CL, with minor effects for race, second RSV season, and antidrug antibody status (deemed not clinically relevant). Congenital heart disease (CHD) and chronic lung disease (CLD) did not significantly impact nirsevimab PK. The final population PK model, based on 8987 PK observations from 2683 participants across 5 clinical trials, successfully predicted PK in an additional cohort of 967 healthy infants. Weight‐banded dosing (50 mg in infants <5 kg; 100 mg in infants ≥5 kg) was predicted to be appropriate for infants ≥1 kg in their first RSV season. Together, these data support weight‐banded dosing of nirsevimab in all infants in their first RSV season, including in healthy infants, infants with CHD or CLD, and in infants born prematurely.
Development of heterogeneous enzymatic cascades with a case study for a separable and recyclable system using a combination of magnetic and nonmagnetic supports
Authors: Lau Elizabeth CHT , Cowan Rhona M , Dodds Kimberley C , McKenna Catherine , Ganin Alexey Y , Campopiano Dominic J , Yiu Humphrey HP 
Published: January 2024

AbstractIn recent years, energy and environmental issues have become more topical as the public have become more conscious about the fragility of the planet we live in. Biocatalysis can have a strong impact on these issues as most enzymes are operated at low energy and solvent‐free environments with often high conversion, activity and selectivity. Enzymatic cascades are multistep reactions that can produce more complex chemical products and mimic in vivo reactions in nature. Therefore, they can provide valuable solutions for many environmental problems. However, enzymes can be expensive, difficult to recycle and wasteful, as seen in other homogeneous systems. For heterogenized biocatalytic systems, enzyme immobilization has been considered to enhance reuse and recycling of enzymes but immobilized enzymes are still underdeveloped for use in cascade systems. Hence, there is an opportunity for advancement. The difficulties for implementing immobilized enzymes in cascades mainly concern enzyme compatibility, compartmentalization and optimization. In this perspective, we have highlighted key examples in using enzymatic cascades using immobilized enzymes, in particular those systems related to the energy and environment sectors. We also demonstrate use of a combination of a magnetic and a nonmagnetic support for enhancing enzyme reuse and recycling in a cascade system, and more importantly, separation of enzymes from each other postreaction. We can foresee that, with significant effort spent on the development, enzyme immobilization could play a significant role in cascades for the green synthesis of fine chemicals. © 2024 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Diffusion Tensor Imaging for Characterizing Changes in Triple‐Negative Breast Cancer During Neoadjuvant Systemic Therapy
Authors: Musall Benjamin C. , Rauch David E. , Mohamed Rania M.M. , Panthi Bikash , Boge Medine , Candelaria Rosalind P. , Chen Huiqin , Guirguis Mary S. , Hunt Kelly K. , Huo Lei , Hwang Ken‐Pin , Korkut Anil , Litton Jennifer K. , Moseley Tanya W. , Pashapoor Sanaz , Patel Miral M. , Reed Brandy J. , Scoggins Marion E. , Son Jong Bum , Tripathy Debu , Valero Vicente , Wei Peng , White Jason B. , Whitman Gary J. , Xu Zhan , Yang Wei T. , Yam Clinton , Adrada Beatriz E. , Ma Jingfei 
Published: January 2024

BackgroundAssessment of treatment response in triple‐negative breast cancer (TNBC) may guide individualized care for improved patient outcomes. Diffusion tensor imaging (DTI) measures tissue anisotropy and could be useful for characterizing changes in the tumors and adjacent fibroglandular tissue (FGT) of TNBC patients undergoing neoadjuvant systemic treatment (NAST).PurposeTo evaluate the potential of DTI parameters for prediction of treatment response in TNBC patients undergoing NAST.Study TypeProspective.PopulationEighty‐six women (average age: 51 ± 11 years) with biopsy‐proven clinical stage I–III TNBC who underwent NAST followed by definitive surgery. 47% of patients (40/86) had pathologic complete response (pCR).Field Strength/Sequence3.0 T/reduced field of view single‐shot echo‐planar DTI sequence.AssessmentThree MRI scans were acquired longitudinally (pre‐treatment, after 2 cycles of NAST, and after 4 cycles of NAST). Eleven histogram features were extracted from DTI parameter maps of tumors, a peritumoral region (PTR), and FGT in the ipsilateral breast. DTI parameters included apparent diffusion coefficients and relative diffusion anisotropies. pCR status was determined at surgery.Statistical TestsLongitudinal changes of DTI features were tested for discrimination of pCR using Mann–Whitney U test and area under the receiver operating characteristic curve (AUC). A P value <0.05 was considered statistically significant.Results47% of patients (40/86) had pCR. DTI parameters assessed after 2 and 4 cycles of NAST were significantly different between pCR and non‐pCR patients when compared between tumors, PTRs, and FGTs. The median surface/average anisotropy of the PTR, measured after 2 and 4 cycles of NAST, increased in pCR patients and decreased in non‐pCR patients (AUC: 0.78; 0.027 ± 0.043 vs. −0.017 ± 0.042 mm2/s).Data ConclusionQuantitative DTI features from breast tumors and the peritumoral tissue may be useful for predicting the response to NAST in TNBC.Evidence Level1Technical EfficacyStage 4
Clinical evaluation of a novel protocol for supportive periodontal care: A randomized controlled clinical trial
Authors: Stähli Alexandra , Ferrari Jvana , Schatzmann Anna Sophia , Weigel Lucienne Dominique , Roccuzzo Andrea , Imber Jean‐Claude , Duong Ho‐Yan , Eick Sigrun , Lang Niklaus P. , Salvi Giovanni E. , Sculean Anton 
Published: January 2024

AbstractBackgroundThe aim of this study was to compare the clinical efficacy and the patient perception of subgingival debridement with either guided biofilm management (GBM) or conventional scaling and root planing (SRP) during supportive periodontal care (SPC).MethodsForty‐one patients in SPC were randomly assigned to either treatment with GBM or SRP every 6 months. The primary outcome was the percentage of bleeding on probing (BoP) at 1 year. Moreover, pocket probing depths (PPD), recession, and furcation involvements were also measured. Full‐mouth and specific site analyzes were performed at baseline, 6 and 12 months of SPC. Patient comfort was evaluated using a visual analogue scale (VAS) at 12 months.ResultsAt 1 year, mean BoP percentage decreased from 12.2% to 9.0% (p = 0.191) and from 14.7% to 7.9% (p = 0.004) for the GBM and SRP groups, respectively. Furcation involved multirooted teeth but no through‐and‐through lesions were significantly fewer in the GBM than in the SRP group after 12 months (p = 0.015). The remaining parameters showed slight improvement in both groups without any statistically significant differences between the two groups after 1 year. Pain evaluation as patient reported outcome measures (pain evaluation) was in favor (p = 0.347) of the SRP group, while overall satisfaction was similar for both groups. Treatment time was not statistically significantly different between the two groups (p = 0.188).ConclusionIn well‐maintained SPC patients, SRP protocols resulted in significant clinical improvements in terms of BoP; however, for the other clinical improvements, similar efficacy for both GBM and SRP was observed.
Analysis of global research on vegetable seedlings and transplants and their impacts on product quality
Authors: Gallegos‐Cedillo Victor M. , Nájera Cinthia , Signore Angelo , Ochoa Jesús , Gallegos Jesús , Egea‐Gilabert Catalina , Gruda Nazim S. , Fernández Juan A. 
Published: January 2024

AbstractBACKGROUNDPrevious research has established that using high‐quality planting material during the early phase of vegetable production significantly impacts success and efficiency, leading to improved crop performance, faster time to harvest and better profitability. In the present study, we conducted a global analysis of vegetable seedlings and transplants, providing a comprehensive overview of research trends in seedling and transplant production to enhance the nutritional quality of vegetables.RESULTSThe analysis involved reviewing and quantitatively analysing 762 articles and 5248 keywords from the Scopus database from 1971 to 2022. We used statistical, mathematical and clustering tools to analyse bibliometrics and visualise the most relevant research topics. A visualisation map was generated to identify the evolution of keywords used in the articles, resulting in five clusters for further analysis. Our study highlights the importance of the size of seed trays for the type of crop, the mechanical seeder used and the greenhouse facilities to produce desirable transplants. We identified grafting and light‐emitting diode (LED) lighting technology as rapidly expanding technologies in vegetable seedlings and transplant production used to promote plant qualitative profile.CONCLUSIONThere is a need for sustainable growing media to optimise resources and reduce input use. Thus, applying grafting, LED artificial lighting, biostimulants, biofortification and plant growth‐promoting microorganisms in seedling production can enhance efficiency and promote sustainable vegetable nutritional quality by accumulating biocompounds. Further research is needed to explore the working mechanisms and devise novel strategies to enhance the product quality of vegetables, commencing from the early stages of food production. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.