bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hidden Markov model‐based ℋ∞ control for singular Markov jump systems under denial of service attacks
Authors: Wang Guanqi , Li Feng , Xia Jianwei , Shen Hao , Wang Jing 
Published: January 2024

AbstractThis work investigates the control problem of discrete‐time singular Markov jump systems against denial of service attacks, in which the Markov state information is seen as restricted access. To solve this situation, a hidden Markov model is introduced. The main objective is to construct a controller with the help of hidden Markov model such that the stochastically admissible of the closed‐loop singular Markov jump systems with limited access mode information can be guaranteed under denial of service attacks. To produce the needed hidden Markov model‐based controller, a matrix contract transformation approach is developed. At the end, a numerical example and a tunnel diode circuit are presented to demonstrate the effectiveness and benefit of the design technique described in this research.
Evaluating the Clinical Efficacy of Pulsed Dye Laser with Sirolimus for Treatment of Capillary Malformations: A Systematic Review
Authors: Tan Isabella J. , Truong Thu M. , Pathak Gaurav N. , Mehdikhani Shaunt , Rao Babar , Cohen Bernard A. 
Published: January 2024

Abstract
Port-wine stains (PWS) are capillary vascular anomalies that are often treated with pulsed-dye laser (PDL). Revascularization limits persistent clearance; however, the anti-angiogenic effects of sirolimus (SIRO) may inhibit revascularization. This review aims to determine differences in PWS outcomes when treated with PDL monotherapy or in combination with SIRO. A systematic review was conducted using PubMed, Cochrane, and Embase databases. The following search terms were used: ‘port wine stain PDL SIRO’, ‘port wine stain PDL’, and ‘port wine stain PDL and topical treatment’ with (MeSH) and (Title/Abstract) limits. The search was limited to the English language and human-subject studies conducted between 1 January 2000 and 1 June 2023. Inclusion criteria included studies evaluating SIRO as an adjunct to PDL in patients with PWS. Data extraction and quality assessment were performed by two independent reviewers. A total of nine studies met the inclusion criteria, which included randomized controlled trials (3), case series (2), case reports (3), and a prospective intrapatient study (1), which represented a total of 58 patients. Five studies showed improvement of a measured post-treatment PDL parameter including shortening treatment time and less frequent dosing. A subset of studies (4/9) which did not demonstrate significant clinical improvements exhibited significant photographic evidence of improvement. Heterogeneity among the studies highlights the need for further research and standardization. While adjunctive SIRO shows promise, larger studies and comprehensive evaluation methods are required to establish conclusive safety and efficacy guidelines to shape clinical decision-making.
Application of cognitive remediation in the world: new experiences from two schizophrenia rehabilitation centers in Togo and Benin
Authors: Deste Giacomo , Kakli Mawuko , Barlati Stefano , Nibbio Gabriele , Dossou Pacôme , Degila Salomon Léonard , Ceraso Anna , Lisoni Jacopo , Calzavara-Pinton Irene , Villa Simona , Vita Antonio 
Published: January 2024

Abstract
Purpose
People with schizophrenia in Sub-Saharan Africa often live in very difficult conditions, suffer important social isolation and usually do not receive any kind of treatment. In this context, some non-governmental initiatives have come to light, providing accommodation, food, primary healthcare, medications and, in some cases, education and rehabilitation. The aims of this study were to assess feasibility, effects, and acceptability of a Cognitive Remediation Therapy (CRT) intervention in the particular context of psychiatric rehabilitation in Togo and Benin.

Methods
Patients diagnosed with schizophrenia accessing the “Saint Camille” association rehabilitation centers in Togo and Benin during the enrollment period were allocated consecutively with a 1:1 proportion to receive a manualized CRT intervention (46 one-hour sessions over 14 weeks) or continuing Treatment As Usual (TAU). The assessment included validated measures of cognitive performance and real-world functioning and was performed at baseline and at the conclusion of treatment.

Results
All subjects that were invited into the study agreed to participate and completed the intervention, for a total of 36 participants. CRT produced greater improvements than TAU in processing speed, working memory, verbal memory, cognitive flexibility, and executive functions measures, with moderate to large effect sizes, in particular in processing speed and working memory domains.

Conclusions
CRT represents a feasible and effective psychosocial intervention that can be implemented even in contexts with very limited resources, and could represent an important instrument to promote the rehabilitation process of people living with schizophrenia in low-income countries.
The Quintilian School in the history of Social Choice: an early tentative step from plurality rule to pairwise comparisons
Authors: Urdánoz Jorge , Colomer Josep M. 
Published: January 2024

AbstractWe present two texts from Roman Empire times that add two early appearances to the stream of the history of Social Choice Theory. One is from the School of Rhetoric of Quintilian (35–96), a contemporary of Pliny the Younger, who developed an early criticism of Plurality rule and, in search of a better method, sketched a choice by pairwise comparisons. The other is from Aulus Gellius (160–180), who used the term “aporia” applied to a voting problem while commenting on a voting by Plurality that yielded counterintuitive or seemingly illogical results. These early analyses and critiques of Plurality rule reveal the flaws of a system that, despite its intuitive or spontaneous appeal, has evident failures that have triggered theoretical reflection from remote times. The two texts also show how paradoxical and problematic situations serve as powerful incentives for reflection and advancement of knowledge and can trigger attempts to address and refine voting and election methods to find more robust and fair alternatives.
Machine learning-based novel continuous authentication system using soft keyboard typing behavior and motion sensor data
Authors: Sağbaş Ensar Arif , Ballı Serkan 
Published: January 2024

AbstractSmartphones utilize various authentication methods, including passwords, fingerprints, and face recognition. While this information is quite practical and easy to remember, it introduces several security issues. The primary concerns involve theft, password forgetfulness, or unauthorized password copying. Implementing behavioral biometrics for user authentication adds an extra layer of security. The main contribution of this study is the utilization of soft keyboard typing behavior, a behavioral biometric, for continuous user recognition. To achieve this, the phone's grip style and typing characteristics of users are scrutinized using data collected from motion sensors and the touchscreen panel. Another challenge in mobile device authentication pertains to recognition accuracy and processing time. To expedite and optimize data classification, a hybrid classification structure is suggested. This structure incorporates correlation-based feature selection and a straightforward logistic regression method, offering rapid and highly accurate classification outcomes—a further contribution of this study. Experimental results demonstrate that user identification can be accomplished in as little as 0.03 ms, with a classification accuracy of up to 93%. Continuous authentication systems offer greater security compared to one-time authentication systems. Nevertheless, these systems might not always yield the most precise results. Overcoming this challenge necessitates the development of an efficient software architecture. In line with this, an additional contribution of this study is an explanation of how to construct a continuous authentication system using the developed architecture.
Water Effects on Elastic S-Wave Propagation and Attenuation Across Single Clay-Rich Rock Fractures: Insights from Ultrasonic Measurements
Authors: Yang Hui , Duan Huan-Feng , Zhu Jianbo , Zhao Qi 
Published: January 2024

AbstractThough previous studies have shown that the presence of water strongly influences wave responses of rock fractures, water effects on wave behaviours across clay-rich rock fractures have been ambiguous until now. In the present study, we conducted considerable ultrasonic measurements on single rock fractures filled with kaolinite-dominant gouges at varying water saturation degrees to investigate the water effects on elastic S-wave propagation and attenuation across clay-rich rock fractures. The experimental results reveal that the S-wave velocity across single clay-rich rock fractures slightly increases and decreases with the progressively increasing water saturation degree. An increase in water saturation leads to a concave trend of the spectral amplitudes, while it moderately affects the central frequency of transmitted S-waves. In addition, the seismic quality factor across single clay-rich rock fractures follows an exponential growth trend with the water saturation, suggesting the exponentially negative relation between S-wave attenuation and the water saturation. We attribute the water saturation-dependent S-wave attributes across single clay-rich rock fractures to the combined effects of the local flow and the degradation of grain contacts. Compared to P-wave, S-wave exhibits less sensitivity to varying water saturation of clay-rich rock fracture. Upon increasing water saturation, S-waves display similar velocity and central frequency trends with P-waves. The tendencies of spectral amplitude and seismic quality factor for S-waves are approximately opposite to those for P-waves as the water saturation degree increases. We interpret these discrepancies by the fact that S-wave attributes across single water-saturated clay-rich rock fractures mainly depend on the properties of the skeletal frame, while the characteristics of the particles, pore fluid, and skeleton frame dominate P-wave behaviours. The outcomes of the current work facilitate our understanding of the fluid effects on the interaction of waves with clay-rich rock discontinuities.
Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells
Authors: Zeuner Simon , Vollmer Johanna , Sigaud Romain , Oppermann Sina , Peterziel Heike , ElHarouni Dina , Oehme Ina , Witt Olaf , Milde Till , Ecker Jonas 
Published: January 2024

Abstract
Purpose
Patients with MYC-amplified Group 3 medulloblastoma (MB) (subtype II) show poor progression-free survival rates. Class I histone deacetylase inhibitors (HDACi) are highly effective for the treatment of MYC-amplified MB in vitro and in vivo. Drug combination regimens including class I HDACi may represent an urgently needed novel treatment approach for this high risk disease.

Methods
A medium-throughput in vitro combination drug screen was performed in three MYC-amplified and one non-MYC-amplified MB cell line testing 75 clinically relevant drugs alone and in combination with entinostat. The drug sensitivity score (DSS) was calculated based on metabolic inhibition quantified by CellTiter-Glo. The six top synergistic combination hits were evaluated in a 5 × 5 combination matrix and a seven-ray design. Synergy was validated and characterized by cell counts, caspase-3-like-activity and poly-(ADP-ribose)-polymerase-(PARP)-cleavage. On-target activity of drugs was validated by immunoprecipitation and western blot. BCL-XL dependency of the observed effect was explored with siRNA mediated knockdown of BCL2L1, and selective inhibition with targeted compounds (A-1331852, A-1155463).

Results
20/75 drugs effectively reduced metabolic activity in combination with entinostat in all three MYC-amplified cell lines (DSS ≥ 10). The combination entinostat and navitoclax showed the strongest synergistic interaction across all MYC-amplified cell lines. siRNA mediated knockdown of BCL2L1, as well as targeted inhibition with selective inhibitors showed BCL-XL dependency of the observed effect. Increased cell death was associated with increased caspase-3-like-activity.

Conclusion
Our study identifies the combination of class I HDACi and BCL-XL inhibitors as a potential new approach for the treatment of MYC-amplified MB cells.

Graphical abstract
Febuxostat ternary inclusion complex using SBE7-βCD in presence of a water-soluble polymer: physicochemical characterization, in vitro dissolution, and in vivo evaluation
Authors: Sakran Wedad , Abdel-Hakim Mai , Teiama Mohammed S. , Abdel-Rashid Rania S. 
Published: January 2024

AbstractFebuxostat (FBX), a potent xanthine oxidase inhibitor, is widely used as a blood uric acid-reducing agent and has recently shown a promising repurposing outcome as an anti-cancer. FBX is known for its poor water solubility, which is the main cause of its weak oral bioavailability. In a previous study, we developed a binary system complex between FBX and sulfobutylether-β-cyclodextrin (SBE7-βCD) with improved dissolution behavior. The aim of the current study was to investigate the effect of incorporating a water-soluble polymer with a binary system forming a ternary one, on further enhancement of FBX solubility and dissolution rate. In vivo oral bioavailability was also studied using LC–MS/MS chromatography. The polymer screening study revealed a marked increment in the solubility of FBX with SBE7-βCD in the presence of 5% w/v polyethylene glycol (PEG 6000). In vitro release profile showed a significant increase in the dissolution rate of FBX from FBX ternary complex (FTC). Oral in vivo bioavailability of prepared FTC showed more than threefold enhancement in Cmax value (17.05 ± 2.6 µg/mL) compared to pure FBX Cmax value (5.013 ± 0.417 µg/mL) with 257% rise in bioavailability. In conclusion, the association of water-soluble polymers with FBX and SBE7-βCD system could significantly improve therapeutic applications of the drug.
Graphical Abstract
3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
Authors: Munoz-Perez Elena , Rubio-Retama J. , Cussó Lorena , Igartua Manoli , Hernandez Rosa Maria , Santos-Vizcaino Edorta 
Published: January 2024

AbstractTraditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conventional suppositories. Additive manufacturing techniques have been recently explored as a suitable innovative tool for suppository fabrication. However, little advancement has been made in composition materials for 3D-printed suppository (3DPS) manufacturing and still, conventional vehicles are often used for construct fabrication, hindering the growth in the field. As a novelty, this study unveils a ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, this study proposes a novel approach for loading drugs into the 3DPS employing for the first time the post-printing loading. Thus, a passive loading strategy of molecular models is developed, demonstrating the versatility and capacity to load molecules of different charges and molecular sizes within the matrix systems. This novel strategy allows adapting the load of a wide range of drugs into a single ink, which simplifies and speeds up the 3DPS technological development process for drugs with different physico-chemical properties. Additionally, in this research, a displacement strategy of the three-dimensional Laponite matrices is developed in order to enhance the drug release capacity through the 3DPS and their disintegration capacity, resulting in a significant improvement of the drug diffusion through the hydrogel matrix and a rapid disintegration of the 3DPS. Finally, our study demonstrates that the obtained 3DPS have a suitable in vivo behavior, being non-obstructive and allowing the normal motility of the rats intestine.
Graphical abstract
KinFit: A Kinematic Fitting Package for Hadron Physics Experiments
Authors: Esmail Waleed , Rieger Jana , Taylor Jenny , Bohman Malin , Schönning Karin 
Published: January 2024

AbstractA kinematic fitting package, , based on the Lagrange multiplier technique has been implemented for generic hadron physics experiments. It is particularly suitable for experiments where the interaction point is unknown, such as experiments with extended target volumes. The package includes vertex finding tools and fitting with kinematic constraints, such as mass hypothesis and four-momentum conservation, as well as combinations of these constraints. The new package is distributed as an open source software via GitHub. This paper presents a comprehensive description of the KinFit package and its features, as well as a benchmark study using Monte Carlo simulations of the $$pp\rightarrow pK^+\Lambda \rightarrow pK^+p\pi ^-$$

p
p
→
p

K
+

Λ
→
p

K
+

p

π
-

reaction. The results show that improves the parameter resolution and provides an excellent basis for event selection.
Rapid generation of time-optimal rendezvous trajectory based on convex optimisation and DNN
Authors: Zhang R.D. , Cai W.W. , Yang L.P. 
Published: January 2024

Abstract
The minimum flight time of spacecraft rendezvous is one of the fundamental indexes for mission design. This paper proposes a rapid trajectory planning method based on convex optimisation and deep neural network (DNN). The time-optimal trajectory planning problem is reconstructed into a double-layer optimisation framework, with the inner being a convex optimisation problem and the outer being a root-finding problem. The thrust properties corresponding to time-optimal control are analysed theoretically. A DNN-based rapid planning method (DNN-RPM) is put forward to improve computational efficiency, in which the trained DNN provides a high-quality initial guess for Newton’s method. The DNN-RPM is extended to search for the optimal entering angle of natural-motion circumnavigation orbit injection problem and the minimum reconfiguration time of spacecraft swarm. Numerical simulations show that the proposed method can improve the computational efficiency while ensuring the calculation accuracy.
Type 2 diabetes mellitus is associated with food addiction in Brazilian women living in poverty
Authors: Silva-Neto Luiz Gonzaga Ribeiro , Silva Júnior André Eduardo da , Bueno Nassib Bezerra , Florêncio Telma Maria de Menezes Toledo 
Published: January 2024

AbstractFood addiction (FA) has been widely investigated. For the first time, two studies reported its association with type 2 diabetes mellitus (DM2) in the general population and populations with mental disorders and undergoing bariatric surgery. However, the relationship between FA and DM2 needs to be better explored in different social contexts and population groups. Given this, the present study aims to evaluate whether DM2 diagnosis is associated with FA diagnosis in women living in poverty. This is a cross-sectional, population-based study conducted in a Brazilian capital city. FA was assessed by the modified Yale Food Addiction Scale (mYFAS) 2.0, and DM2 diagnosis was assessed by self-reporting of previous medical diagnosis. The association was assessed by multivariable Poisson regression with robust variance estimation adjusted for age, poverty situation, race/skin colour, physical activity and BMI. A total of 1878 women were included, of whom 15·1 % had FA and 3·2 % had a medical diagnosis of DM2. In the multivariable analysis, the medical diagnosis of DM2 was associated with FA (prevalence ratio, PR: 2·18; 95 % CI (1·26, 3·76)). The DM2 diagnosis was also identified to be associated with role interference (PR: 1·93; 95 % CI (1·01, 3·67)) symptom of FA. In conclusion, a positive association between FA and DM2 in women living in poverty was observed, information that adds to the current evidence already available in the literature, pointing to a new line of research and integrated care.
Inverse association between maternal serum concentrations of trace elements and risk of spontaneous preterm birth: a nested case–control study in China
Authors: Li Nana , Yu Ping , Liu Zhen , Tao Jing , Li Lu , Wang Meixian , Wei Hongwei , Zhu Yibing , Deng Ying , Kang Hong , Li Yuting , Li Xiaohong , Liang Juan , Wang Yanping , Zhu Jun 
Published: January 2024

AbstractFew studies have evaluated the joint effect of trace elements on spontaneous preterm birth (SPTB). This study aimed to examine the relationships between the individual or mixed maternal serum concentrations of Fe, Cu, Zn, Se, Sr and Mo during pregnancy, and risk of SPTB. Inductively coupled plasma MS was employed to determine maternal serum concentrations of the six trace elements in 192 cases with SPTB and 282 controls with full-term delivery. Multivariate logistic regression, weighted quantile sum regression (WQSR) and Bayesian kernel machine regression (BKMR) were used to evaluate the individual and joint effects of trace elements on SPTB. The median concentrations of Sr and Mo were significantly higher in controls than in SPTB group (P < 0·05). In multivariate logistic regression analysis, compared with the lowest quartile levels of individual trace elements, the third- and fourth-quartile Sr or Mo concentrations were significantly associated with reduced risk of SPTB with adjusted OR (aOR) of 0·432 (95 CI < 0·05). In multivariate logistic regression analysis, compared with the lowest quartile levels of individual trace elements, the third- and fourth-quartile Sr or Mo concentrations were significantly associated with reduced risk of SPTB with adjusted aOR of 0·432 (95 % CI 0·247, 0·756), 0·386 (95 % CI 0·213, 0·701), 0·512 (95 % CI 0·297, 0·883) and 0·559 (95 % CI 0·321, 0·972), respectively. WQSR revealed the inverse combined effect of the trace elements mixture on SPTB (aOR = 0·368, 95 % CI 0·228, 0·593). BKMR analysis confirmed the overall mixture of the trace elements was inversely associated with the risk of SPTB, and the independent effect of Sr and Mo was significant. Our findings suggest that the risk of SPTB decreased with concentrations of the six trace elements, with Sr and Mo being the major contributors.
‘… And We have made from water every living thing’: water conservation and the Holy Qur’an
Authors: Blankinship Lisa A , Gillaspie Sarah , Obaideen Khaled , Aboul-Enein Basil H 
Published: January 2024

SummaryWater conservation is of particular importance for arid regions, including many Muslim-majority countries. With the added pressures of human population growth and expansion and global climate change, water conservation efforts are imperative to extending the life of current water supplies as well as to sourcing water treatment methods that are religiously congruent. We review Qur’anic verses that address water usage and conservation. We searched the English translations of the King Fahd Complex for the Printing of the Holy Qur’an and the King Saud University Electronic Moshaf Project for Qur’anic scripture related to water and water conservation. A total of 25 verses were found that related to creation, water usage for agriculture and food provision/production and as a common resource for humanity. Qur’anic scripture encourages gratitude for water and wise stewardship of this resource. Specific prohibitions against the reuse of water (e.g., treated water) were not found, and recent Islamic literature supports the use of cleansed greywater. Treated greywater may thus be an additional source for agricultural needs, thus reducing the stress placed on already limited water supplies. Water conservation falls within Qur’anic scripture.