bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with genetic markers for rotator cuff disease in patients with atraumatic rotator cuff tears
Authors: Yanik Elizabeth L. , Saccone Nancy L. , Aleem Alexander W. , Chamberlain Aaron M. , Zmistowski Benjamin , Sefko Julianne A. , Keener Jay D. 
Published: December 2023

AbstractFor atraumatic rotator cuff tears, genetics contributes to symptomatic tear risk and may influence rotator cuff healing after surgical repair. But little is known about how genetic factors influence rotator cuff tear patient characteristics at presentation. We collected saliva samples for genotyping from atraumatic rotator cuff tear patients. We examined nine single nucleotide polymorphisms (SNPs) associated with cuff tears in prior literature. We estimated associations of SNP dosage with (1) age at tear diagnosis, (2) bilateral atraumatic tear prevalence, and (3) tear size. Linear regression was used to estimate associations with diagnosis age adjusted for sex and principal components. Logistic regression and ordinal logistic regression were used to estimate associations with bilateral tear prevalence and tear size category, respectively, adjusting for age, sex, and principal components. Of 344 eligible patients, 336 provided sufficient samples for genotyping. Median age at tear diagnosis was 61, 22% (N = 74) had bilateral atraumatic tears, and 9% (N = 29) had massive tears. SNP rs13107325 in the SLC39A8 gene and rs11850957 in the STXBP6 gene were associated with younger diagnosis age even after accounting for multiple comparisons (rs13107325: −4 years, 95% CI = −6.5, −1.4; rs11850957: −2.7 years, 95% CI = −4.3, −1.1). No other significant associations were observed with diagnosis age, tear size, or bilateral tear prevalence. SLC39A8 encodes a Mn transporter. STXBP6 may play a role in inflammatory responses by altering phagocytosis and antigen presentation of monocytes and macrophages. Further research is needed to determine if genetic markers can be used alongside patient characteristics to aid in identifying optimal surgical repair candidates.
Anti‐diabetic mechanism and potential bioactive peptides of casein hydrolysates in STZ/HFD‐induced diabetic rats
Authors: Wang Chenyang , Luo Donghui , Zheng Lin , Zhao Mouming 
Published: December 2023

AbstractBACKGROUNDCasein hydrolysates have attracted much interest as anti‐diabetic food, but their hypoglycemic mechanism and biopeptides are not well understood. This study aimed to explore the anti‐diabetic mechanism and potential biopeptides of casein hydrolysates in streptozotocin/high‐fat‐diet‐induced diabetic rats and HepG2 cells.RESULTSOral administration of casein hydrolysate prepared with papain–Flavourzyme combination (P‐FCH) decreased fasting blood glucose, improved oral glucose tolerance, and reduced HbA1c values in diabetic rats. P‐FCH was ineffective in alleviating insulin resistance (homeostasis model assessment and insulin sensitivity index) and enhancing hepatic insulin signaling transduction (phosphorylated Akt, hexokinase activity, and pyruvate kinase activity) in diabetic rats. However, P‐FCH significantly upregulated adenosine monophosphate‐activated protein kinase phosphorylation and glucose transporter‐2 expression, inhibited phosphoenolpyruvate carboxylase kinase activity, and elevated glycogen content in liver tissue of diabetic rats. Furthermore, P‐FCH increased glucose consumption independently in normal and insulin‐resistant HepG2 cells without the presence of insulin. The peptide composition of P‐FCH was characterized. The potential biopeptides in P‐FCH showed the sequence characteristic of a Val at the N‐terminal or a Pro at the P2 position, and the hypoglycemic activity of Val‐Pro‐Leu‐Gly (the most potential biopeptide in P‐FCH) was verified by oral glucose tolerance test in mice.CONCLUSIONThese results suggested that activation of the non‐insulin‐mediated AMPK pathway might be the determinant mechanism of P‐FCH on the hypoglycemic effect. The novel peptide Val‐Pro‐Leu‐Gly in P‐FCH was effective in reducing blood glucose levels when orally administered to mice. © 2023 Society of Chemical Industry.
Hydrogel Scaffolds with Controlled Postgelation Modulation of Structures for 3D Cell Culture and Tissue Engineering
Authors: Yang Jiaxuan , Rong Yan , Chen Xuesi , He Chaoliang 
Published: December 2023

AbstractHydrogels are hydrophilic three‐dimensional networks containing a large amount of water, with physicochemical properties similar to extracellular matrix and controlled mechanical strength, making them ideal scaffolds for 3D cell culture and tissue engineering. However, the cross‐linked hydrogel network often restricts the migration of cells and the exchange of nutrients, which affects cell proliferation and the development of normal tissues. In recent years, hydrogels with pore‐channel structures have attracted significant attention, but these spatial structures are usually preconstructed before gelation, posing challenges in meeting the dynamic physiological conditions required during cell and tissue growth. Therefore, considerable efforts have been devoted to structurally regulate the scaffolds after gelation, so as to enhance the interactions between the scaffolds and cells for promoting the growth of cells and tissues. This review firstly outlines the preparation of hydrogel scaffolds with pore structure and the necessity of postgelation pore modulation. Two types of methods for postgelation pore modulation, including chemical degradation and physical dissolution, are then summarized. Finally, the potential application of such postgelation structural modulation in 3D cell culture and tissue engineering is discussed.
Novel Lauric Acid‐Butyric Structural Lipid Inhibits Inflammation: Small Intestinal Microbes May Be Important Mediators
Authors: Liu Wangxin , Zhao Minjie , Huang Ying , Feng Fengqin , Luo Xianliang , Wang Jing 
Published: December 2023

ScopeButyric acid (C4) and lauric acid (C12) are recognized as functional fatty acids, while the health benefits of the structural lipids they constitute remain unclear.Methods and resultsIn this study, lauric acid‐butyric structural lipid (SLBL) is synthesized through ultrasound‐assisted enzyme‐catalyzed acidolysis and its health benefits are evaluated in a high‐fat diet‐induced obesity mouse model. SLBL and its physical mixture (MLBL) do not significantly inhibit obesity in mice. However, SLBL treatment increases the ratio of n3/n6 fatty acids in the liver and improves obesity‐induced hepatic lipid metabolism disorders. Furthermore, the expression of liver pro‐inflammatory cytokines (interleukin [IL]‐6, IL‐1β, TNF‐α) are significantly suppressed by SLBL, while the expression of anti‐inflammatory cytokine (IL‐10) is increased. Moreover, SLBL ameliorates the dysbiosis of small intestinal microbes induced by high‐fat diet and regulates microbial community structure to be close to the control group. Especially, SLBL significantly alleviates the high‐fat diet‐induced decrease in Dubosiella and Bifidobacterium abundance. Correlation analysis reveals that SLBL treatment increases the abundance of microorganisms with potential anti‐inflammatory function and decreases the abundance of potentially pathogenic bacteria.ConclusionIn all, small intestinal microbes may be a significant bridge for the positive anti‐inflammatory effects of SLBL, while the exact mechanism remains to be clarified.
A case series evaluating patient perceptions after switching from nusinersen to risdiplam for spinal muscular atrophy
Authors: Powell Jeffrey C. , Meiling James B. , Cartwright Michael S. 
Published: December 2023

AbstractIntroduction/AimsIn 2016, nusinersen became the first disease‐modifying medication approved by the U.S. Food and Drug Administration (FDA) for spinal muscular atrophy (SMA). With the later availability of risdiplam in 2020, individuals now have the option of switching from nusinersen to risdiplam. Limited published data exist to inform this decision. This study aims to evaluate the perceptions and experiences of adult participants and parents of minor participants who previously received nusinersen and switched to risdiplam for the treatment of SMA.MethodsInstitutional Review Board (IRB) approval was obtained from the Wake Forest IRB prior to the initiation of this study. A cross‐sectional, observational study, with qualitative and quantitative data gathered via questionnaire and medical record review, was performed. Inclusion criteria included (1) prior diagnosis of SMA, (2) previous treatment with nusinersen, and (3) change to treatment with risdiplam. No participants were excluded based on age.ResultsFourteen participants—eight adults and six children—were enrolled in the study. Respondents noted improvements in physical function with each medication. Overall, respondents reported worse satisfaction with the method of delivery of the intrathecally delivered nusinersen compared to the orally‐delivered risdiplam, but no respondent reported negative overall satisfaction with either medication. A majority (78.6%) of respondents reported that switching from nusinersen to risdiplam was the correct decision.DiscussionThese results suggest that most patients are satisfied when switching from nusinersen to risdiplam, with the method of delivery being a primary factor.
European scenarios for future biological invasions
Authors: Pérez‐Granados Cristian , Lenzner Bernd , Golivets Marina , Saul Wolf‐Christian , Jeschke Jonathan M. , Essl Franz , Peterson Garry D. , Rutting Lucas , Latombe Guillaume , Adriaens Tim , Aldridge David C. , Bacher Sven , Bernardo‐Madrid Rubén , Brotons Lluís , Díaz François , Gallardo Belinda , Genovesi Piero , González‐Moreno Pablo , Kühn Ingolf , Kutleša Petra , Leung Brian , Liu Chunlong , Pagitz Konrad , Pastor Teresa , Pauchard Aníbal , Rabitsch Wolfgang , Robertson Peter , Roy Helen E. , Seebens Hanno , Solarz Wojciech , Starfinger Uwe , Tanner Rob , Vilà Montserrat , Roura‐Pascual Núria 
Published: December 2023

Abstract

Invasive alien species are one of the major threats to global biodiversity, ecosystem integrity, nature's contributions to people and human health. While scenarios about potential future developments have been available for other global change drivers for quite some time, we largely lack an understanding of how biological invasions might unfold in the future across spatial scales.

Based on previous work on global invasion scenarios, we developed a workflow to downscale global scenarios to a regional and policy‐relevant context. We applied this workflow at the European scale to create four European scenarios of biological invasions until 2050 that consider different environmental, socio‐economic and socio‐cultural trajectories, namely the European Alien Species Narratives (Eur‐ASNs).

We compared the Eur‐ASNs with their previously published global counterparts (Global‐ASNs), assessing changes in 26 scenario variables. This assessment showed a high consistency between global and European scenarios in the logic and assumptions of the scenario variables. However, several discrepancies in scenario variable trends were detected that could be attributed to scale differences. This suggests that the workflow is able to capture scale‐dependent differences across scenarios.

We also compared the Global‐ and Eur‐ASNs with the widely used Global and European Shared Socioeconomic Pathways (SSPs), a set of scenarios developed in the context of climate change to capture different future socio‐economic trends. Our comparison showed considerable divergences in the scenario space occupied by the different scenarios, with overall larger differences between the ASNs and SSPs than across scales (global vs. European) within the scenario initiatives.

Given the differences between the ASNs and SSPs, it seems that the SSPs do not adequately capture the scenario space relevant to understanding the complex future of biological invasions. This underlines the importance of developing independent but complementary scenarios focussed on biological invasions. The downscaling workflow we implemented and presented here provides a tool to develop such scenarios across different regions and contexts. This is a major step towards an improved understanding of all major drivers of global change, including biological invasions.

Read the free Plain Language Summary for this article on the Journal blog.
Effect of delamination on the dynamic characteristics of thin‐walled carbon fiber‐reinforced polymer tube
Authors: Luo Zhong , Yu Bing , Zhang Chengshuang , Zhang Xiaoxia , Sun Xinyu 
Published: December 2023

AbstractThin‐walled carbon fiber‐reinforced‐polymer (CFRP) tubes are susceptible to damage, which impacts their dynamic characteristics. This paper investigates the influence of delamination damage on the dynamic properties of thin‐walled CFRP tubes through finite element simulation and experimental methods. A transversely isotropic principal model is employed to establish the geometric model. Delamination damage is induced using the cohesive zone model and the secondary stress criterion. Both circumferential and elliptical delamination cases are studied. The modal test is conducted using the hammer excitation method. It is observed that the finite element model aligns with the experimental results. It is discovered that the larger the delamination size, the lower the natural frequency for a given damage location. The location of the delamination within a single layer has minimal effect on the natural frequency. The natural frequency exhibits a symmetrical pattern of decreasing and then increasing as the delamination shifts from the sides toward the center layer. Positional information is discernible in the modal shape, which can be utilized for delamination detection and localization.Highlights
The damage model is built by transversal isotropic equation and cohesive unit.
Finite element model is built with various delamination sizes and locations for two cases.
Modal tests are performed on CFRP tubes and obtained good accuracy.
Effect of delamination size and location on dynamic parameters is discussed.
Facile synthesis of functionalized boron nitride nanosheets for photo‐cured 3D printing of high thermal conductive composites
Authors: Zhao Yaxing , Ban Lulu , Chen Chen , Yang Binjie , Zhang Shuai , Chen Chao , Cui Zhengwei , Liu Ren , Sang Xinxin 
Published: December 2023

AbstractAddressing the concern of heat accumulation in electronic devices, considerable research efforts have been dedicated to develop composites that are thermally conductive yet electrically insulative. Incorporating hexagonal boron nitride (h‐BN) as fillers shows promise in enhancing the thermal conductivity of polymer composites. However, notable challenges arise from difficulties in achieving well dispersion and establishing efficient three‐dimensional thermal conductive networks. This work demonstrated an efficient photocurable direct ink writing (DIW) printing method to fabricate functional h‐BN nanosheets (A‐BNNS)/epoxy acrylate (EA) resin‐based thermal conductive composites (A‐BNNS/EA). Apple polyphenol‐assisted ball milling was employed to fabricate functionalized BN nanosheets (A‐BNNS). Subsequently, A‐BNNS/EA inks were 3D printed using DIW to create thermally conductive composites, which were then UV‐cured. The composite containing 55 wt% A‐BNNS demonstrated an impressive thermal conductivity (TC) of 3.44 W/(m K). The utilization of 3D printing technology enables an onion‐like dispersion of A‐BNNS within the polymer matrix, effectively constructing three‐dimensional thermal conductive networks. This contribution significantly enhances the overall thermal conductivity.Highlights
The functional BNNS (A‐BNNS) was achieved by apple polyphenol‐assisted ball milling.
The utilization of photocurable 3D printing technology for producing high thermal conductivity materials are efficient.
A‐BNNS exhibited an onion‐like distribution and effectively constructed a 3D thermal conductive network within the polymer matrix
The composites demonstrate excellent thermal conductivity and favorable heat dissipation property.
Exploration of D‐limonene as a sex pheromone for males of Bactrocera minax (Diptera: Tephritidae)
Authors: Cheng Xiaoqin , Wen Qiang , Li Yunna , Wang Shanshan , Fan Gang , Ma Zhaocheng , Guo Yuancheng , Li Xiaoxue , Zhang Hongyu 
Published: December 2023

AbstractBACKGROUNDBactrocera minax is a devastating pest of citrus fruits. However, there have been no effective control measures before. Few reports on the sex pheromones of B. minax are available.RESULTSIn this study, nine of the volatile compounds in adult females were identified using headspace solid‐phase microextraction (HS‐SPME) in combination with gas chromatography–mass spectrometry (GC–MS). Among them, d‐limonene, caprolactam, 2‐Nitro‐1H‐imidazole, and creatinine could evoke antennal responses in males. Field bioassays showed that only d‐limonene could lure male flies, with a relative lure rate of 78.18% in all tested samples, which was significantly higher than that of paraffin oil control, while all volatile compounds did not have any lure effective to female flies. Moreover, d‐limonene was diluted with paraffin oil into differential concentrations, the lure effect on males was better at 100, 500, and 800 μL d‐limonene mL−1 than pure d‐limonene (1000 μL mL−1). The relative male lure rate of d‐limonene at 100 μL mL−1 was 85.88%, which was significantly higher than that of food−baits (14.12%) on day 3. However, d‐limonene was unattractive to female and male Bactrocera dorsalis and Zeugodacus tau. Further kinetic analysis showed that female adults released d‐limonene around 15‐day post eclosion. Electroantennography 1 results showed that 500 μL mL−1 d‐limonene evoked the strongest responses to antennae of 10‐ to 25‐day‐old male flies.CONCLUSIONOur results indicated that d‐limonene could be a sex pheromone from female flies of B. minax, and it could be used as a male‐specific sex attractant for B. minax. © 2023 Society of Chemical Industry.
Corpse‐associated odours elicit avoidance in invasive ants
Authors: Wagner Thomas , Czaczkes Tomer J 
Published: December 2023

AbstractBACKGROUNDInvasive ants, such as Linepithema humile (the Argentine ant), pose a global threat, necessitating a better understanding of their behaviour in order to improve management strategies. Traditional eradication methods, including baiting, have had limited success, but the causes of control failure are not always clear. This study aims to investigate whether ants form associations between food odours and corpses, and subsequently avoid areas or food sources with food odours associated with corpses. We propose that ants may learn to avoid toxic baits in part because of their association with ant corpses, which could have implications for pest control strategies.RESULTSAnts were tested on a Y‐maze after exposure to scented corpses or dummies. 69% (n = 64) of ants avoided branches bearing the scent of scented corpses. Colonies neglected food with corpse‐associated odours, with only 42% (n = 273) of foragers feeding from such sources. However, if corpses were produced by feeding ants scented toxicant, focal ants encountering these corpses did not avoid the corpse‐associated scent on a Y‐maze (53%, n = 65). In dual‐feeder tests, ants did not avoid feeding at food sources scented with odours associated with conspecific corpses.CONCLUSIONConspecific corpses act as a negative stimulus for ants in a foraging situation, potentially causing avoidance of toxic baits. This study suggests adding odours to baits and cycling them to disrupt the bait–corpse association may be helpful. Interestingly, although avoidance of baits was observed, feeding preferences were not significantly affected. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Single‐Layer Hexagonal Boron Nitride Nanopores as High‐Performance Ionic Gradient Power Generators
Authors: Liu Ting‐Ran , Fung Man Yui Thomas , Yeh Li‐Hsien , Chiang Chun‐Hao , Yang Jhih‐Sian , Kuo Pai‐Chia , Shiue Jessie , Chen Chia‐Chun , Chen Chun‐Wei 
Published: December 2023

AbstractAtomically thin two‐dimensional (2D) materials have emerged as promising candidates for efficient energy harvesting from ionic gradients. However, the exploration of robust 2D atomically thin nanopore membranes, which hold sufficient ionic selectivity and high ion permeability, remains challenging. Here, the single‐layer hexagonal boron nitride (hBN) nanopores are demonstrated as various high‐performance ion‐gradient nanopower harvesters. Benefiting from the ultrathin atomic thickness and large surface charge (also a large Dukhin number), the hBN nanopore can realize fast proton transport while maintaining excellent cation selectivity even in highly acidic environments. Therefore, a single hBN nanopore achieves the pure osmosis‐driven proton‐gradient power up to ≈3 nW under 1000‐fold ionic gradient. In addition, the robustness of hBN membranes in extreme pH conditions allows the ionic gradient power generation from acid‐base neutralization. Utilizing 1 m HCl/KOH, the generated power can be promoted to an extraordinarily high level of ≈4.5 nW, over one magnitude higher than all existing ionic gradient power generators. The synergistic effects of ultrathin thickness, large surface charge, and excellent chemical inertness of 2D single‐layer hBN render it a promising membrane candidate for harvesting ionic gradient powers, even under extreme pH conditions.
Dynamic Room Temperature Phosphorescence of Silane‐Functionalized Carbon Dots Confining within Silica for Anti‐Counterfeiting Applications
Authors: Chen Junyu , Tan Jieqiang , Liang Ping , Wu Caijuan , Hou Zaili , Shen Kuangyu , Lei Bingfu , Hu Chaofan , Zhang Xuejie , Zhuang Jianle , Sun Luyi , Liu Yingliang , Zheng Mingtao 
Published: December 2023

AbstractRoom temperature phosphorescent (RTP) materials with long‐lived, excitation‐dependent, and time‐dependent phosphorescence are highly desirable but very hard to achieve. Herein, this work reports a rational strategy of multiple wavelength excitation and time‐dependent dynamic RTP color by confining silane‐functionalized carbon dots (CDs) in a silica matrix (Si‐CDs@SiO2). The Si‐CDs@SiO2 possesses unique green‐light‐excitation and a change in phosphorescence color from yellow to green. A slow‐decaying phosphorescence at 500 nm with a lifetime of 1.28 s and a fast‐decaying phosphorescence at 580 nm with a lifetime of 0.90 s are observed under 365 nm of irradiation, which originated from multiple surface triplet states of the Si‐CDs@SiO2. Given the unique dynamic RTP properties, the Si‐CDs@SiO2 are demonstrated for applications in fingerprint recognition and multidimensional dynamic information encryption. These findings will open an avenue to explore dynamic phosphorescent materials and significantly broaden their applications.
Porous Tellurium‐Doped Ruthenium Dioxide Nanotubes for Enhanced Acidic Water Oxidation
Authors: Liu Guo‐Qiang , Yang Yuan , Zhang Xiao‐Long , Li Hui‐Hui , Yu Peng‐Cheng , Gao Min‐Rui , Yu Shu‐Hong 
Published: December 2023

AbstractElectrocatalysts with high activity and durability for acidic oxygen evolution reaction (OER) play a crucial role in achieving cost‐effective hydrogen production via proton exchange membrane water electrolysis. A novel electrocatalyst, Te‐doped RuO2 (Te–RuO2) nanotubes, synthesized using a template‐directed process, which significantly enhances the OER performance in acidic media is reported. The Te–RuO2 nanotubes exhibit remarkable OER activity in acidic media, requiring an overpotential of only 171 mV to achieve an anodic current density of 10 mA cm−2. Furthermore, they maintain stable chronopotentiometric performance under 10 mA cm−2 in acidic media for up to 50 h. Based on the experimental results and density functional calculations, this significant improvement in OER performance to the synergistic effect of large specific surface area and modulated electronic structure resulting from the doping of Te cations is attributed.