bluuebunny/crossref_metadata_2025_split huggingface dataset:
The initial symptoms in multiple sclerosis: clinical and demographic data of Çorum province
Authors: ELİAÇIK Sinan , AYKAÇ Serdar 
Published: December 2023

Aims: Multiple sclerosis, which has individual and societal effects such as being observed in young and middle-aged people and its long and expensive treatment process, has become an important public health issue.
Methods: Between January 2022 and January 2023, 103 patients with MS were evaluated using anamnesis, neurological examinations, and neuroimaging results. The patients’ initial findings upon their MS diagnosis, the duration of diagnosis, their neurological observations in the past month, and their clinical categorization were examined.
Results: Out of the 103 patients, 70 (67.96%) were female, and 33 (32.04%) were male, which was detected as a female-to-male ratio of 2.12/1. The average age of the patients was 34.41±8.4 years, and the average disease duration was 8±5.8 years. The initial findings in females were as follows; 25 patients (35.7%) had sensory, 13 patients (18.6%) had motor (pyramidal), 17 patients (24.3%) had brain stem-cerebellar, 10 patients (14.3%) had a visual impairment, and 5 patients (7.1%) had other findings. The distributions of the initial symptoms in males were as follows; 12 patients (36.4%) were motor (pyramidal), 10 patients (30.3%) were sensory, 5 patients (15.1%) were brain stem-cerebellar, 5 patients (15.1%) had visual impairment, and 1 patient (.3.1%) had other findings. The mean Expanded Disability Status Scale (EDSS) at the time of initial diagnosis was 2.5± 1.5. Among the 60 patients with RRMS who were first diagnosed, the duration elapsed between initial symptom onset and diagnosis was 12.8± 5.7 months.
Conclusion: Demographic information of the MS patients followed up in our clinic, their initial complaints, frequency of clinical subtypes, differences between clinical subtypes, their clinical status in the last month, and their EDDS at their initial diagnosis and last follow-up are presented. As this represents the first data on the epidemiology of MS in our city, we believe it will contribute to the national data of Turkey and help raise MS awareness among clinicians.
Anti-Müllerian hormone and HOMA-IR in different phenotypes of polycystic ovary syndrome on insulin resistance
Authors: ÖNAL Murat , ÇALI ÖZTÜRK Halime 
Published: December 2023

Aims: To examine the link between serum anti-mullerian hormone (AMH) levels and homeostatic model assessment of insulin resistance (HOMA-IR) in different phenotypes of polycystic ovary syndrome (PCOS).
Methods: This retrospective study included 120 patients aged 18-30 who visited our polyclinics between June 2021 and December 2022. Patients were divided into four groups based on the Rotterdam criteria for PCOS phenotypes. A control group of 24 individuals was also included. Clinical data, hormonal profiles, and metabolic parameters were obtained from medical records.
Results: There were significant differences in AMH, follicle stimulating hormone (FSH), luteinizing hormone (LH), and high-density lipoprotein (HDL) levels among the PCOS phenotypes and control group. AMH levels were highest in phenotype 1 (oligo/anovulation + hyperandrogenism + polycystic ovaries) and lowest in the control group. FSH were highest in phenotype 4 (oligo/anovulation + polycystic ovaries) and lowest in the control group. LH were highest in phenotype 2 (oligo/anovulation + hyperandrogenism). HOMA-IR was highest in phenotype 1. However, there were no significant differences in AMH or HOMA-IR levels among the PCOS phenotypes.
Conclusion: Our study found hormone level differences among PCOS phenotypes but no significant differences in AMH or HOMA-IR. This suggests AMH may not distinguish between phenotypes and insulin resistance may not differ significantly among phenotypes.
Inquiring about the link between urotensin-II and coronary collateral development in coronary artery patients with and without diabetes
Authors: KARAKUŞ Yasin , AÇIKGÖZ Nusret 
Published: December 2023

Aims: Coronary collateral circulation consists of vascular channels activated to maintain perfusion in major epicardial coronary arteries in severe stenosis or occlusion. Yet, coronary collateral development (CCD) in diabetic patients was previously proven to be poor. Urotesin-II (U-II) is famous for being the most potent vasoconstrictor agent, and plasma levels are known to elevate in diabetic patients and play an important role in diabetic complications. In this study, we inquired about the link between U-II levels and the development of coronary collaterals between diabetic and non-diabetic patients with coronary artery disease (CAD).
Methods: We recruited 31 diabetic and 30 non-diabetic patients with 95% or more coronary artery stenosis or occlusion and considered Rentrop’s classification for grading collaterals. In this sense, while Rentrop grades 0-1 are regarded as poor CCD, Rentrop grades 2-3 correspond to well-developed collaterals. Moreover, we compared the patients’ serum levels of U-II by the degree of CCD.
Results: The findings revealed that demographic characteristics did not significantly differ between the groups (p >0.05). Although CCD seemed worse in diabetic patients than those without diabetes (DM), the finding was not statistically significant. However, the diabetic patients had significantly higher U-II levels than non-diabetic patients (388.1±314.2 vs. 229.8±216.9, p=0.026). Despite not being significant, U-II levels were higher in patients with poor CCD than those with well-developed collaterals in the non-diabetic group (370.6±298; 178.6±158.3, p=0.2). In the diabetic group, on the other hand, U-II levels were significantly higher in patients with poor CCD and significantly lower in patients with good CCD (582.7±316.4 and 180.4±121.6, respectively; p
Evaluation of variants in maturity onset of diabetes young related genes in Balıkesir region
Authors: GERİK ÇELEBİ Hamide Betül , DEMİRAL Meliha 
Published: December 2023

Aims: Maturity-onset diabetes of the young (MODY) is an early-onset, monogenic diabetes with an autosomal dominant inheritance pattern. Single gene mutations that cause dysfunction in pancreatic beta cells are responsible for MODY etiology. In this study, we investigated the genetic variants involved in the etiopathogenesis of MODY in our region.
Methods: Between May 2018 and April 2023, 40 pediatric patients (n=25 females, n=15 males) with a clinical diagnosis of MODY were evaluated by targeted genome sequencing.
Results: Among the 40 pediatric patients included in this study, variants in MODY-associated genes were detected in 21 patients (52.5%), eight (38.09%), of which were pathogenic (38.09%), five (23.8%) were probable pathogenic, and eight (38.09%), were of uncertain significance.
Conclusion: In this study, genetic diagnostic yield (including pathogenic and likely pathogenic variants) was detected in 32.5% (13/40) patients with MODY using targeted genome sequencing analysis. This rate is consistent with other studies. However, unlike other similar studies, the MODY12 subtype was the second most frequent in our study. In addition, nine novel variants were reported, including ABCC8 (n=3), CEL (n=2), KLF11 (n=1), GCK (n=1), HNF1A (n=1), and HNF1B (n=1) genes. We have presented clinical findings to improve genotype-phenotype correlation in the literature for novel variants.
Pneumococcal and influenza vaccine awareness in individuals over 65 years
Authors: SAYACA Nurhan 
Published: December 2023

Aims: Vaccination is of great importance due to the increased risk of infection as a result of changes in the immune system with aging and the weak immune response against these infections. In this study, it was aimed to determine the pneumococcal and influenza vaccination awareness and vaccination rates of individuals aged 65 years and over, to direct the unvaccinated individuals to be vaccinated and to protect them from possible infections and complications.
Methods: A questionnaire form was filled in by asking demographic information, awareness of influenza and pneumococcal vaccines and the status of vaccination of individuals aged 65 years and over who applied to the clinic between June and September 2020. Unvaccinated individuals were referred to the vaccination unit.
Results: A total of 553 elderly individuals aged 65 years and over, 338 women and 215 men, were included in the study. Among the study participants, the rate of patients with awareness of influenza/pneumococcal vaccine was 48.5%. Although the vaccination awareness rate was higher in males, non-smokers, those with higher education level, those with at least one of the comorbidities such as hypertension, coronary artery disease, hyperlipidemia, chronic renal failure, vaccination rates were lower in patients with these comorbidities and additionally diabetes mellitus. The majority of individuals with awareness were informed by healthcare workers. The rate of vaccination among the individuals participating in the study was 18.4%. Vaccination was higher in individuals with awareness. While 5.3% of those who were not vaccinated were hospitalized for pneumonia, those who were vaccinated did not have pneumonia severe enough to require hospitalization.
Conclusion: In order to fight with the increasing vaccine hesitancy in our society, healthcare workers should be educated, the media should be supported, and vaccination should be encouraged in every clinic application.
Evaluation of hematological parameters in the differentiation of bile reflux gastritis and Helicobacter pylori gastritis in children
Authors: KIRAN TAŞCI Ezgi 
Published: December 2023

Aims: Endoscopy is used in the diagnosis of bile reflux gastritis and Helicobacter pylori (H. pylori) gastritis. However, endoscopy is an invasive procedure with complications. The study proposes that by analyzing the absolute neutrophil - lymphocyte count ratio and mean platelet volume, it might be possible to distinguish between H. pylori gastritis and bile reflux gastritis.
Methods: All patients with endoscopic and histopathological confirmation H. pylori gastritis of (Group 1), bile reflux gastritis (Group 2), or both (Group 3) were included in this retrospective study. White blood cells, absolute neutrophil count, absolute lymphocyte count and mean platelet volume were analyzed in all patients. The absolute neutrophil/lymphocyte ratio was calculated.
Results: 218 patients were included in the study. The median absolute neutrophil-lymphocyte ratio was 1.33 in H. pylori gastritis, 1.56 in bile reflux gastritis, and 1.47 in both. The mean value of mean platelet volume was 9.97±0.82 in H. pylori gastritis, 10.16±0.81 in bile reflux gastritis, and 10.06±0.88 in both. The absolute neutrophil/lymphocyte ratio and mean platelet volume did not differ significantly between the groups.
Conclusion: According to our results, absolute neutrophil/lymphocyte ratio cannot be used as a differential diagnosis marker in children with H. pylori gastritis and bile reflux gastritis.
The prevalence of anomalies in the lumbar spine in the Turkish male population
Authors: KURTULUŞ Burhan , ATLI Osman Yağız , DUMAN Evrim 
Published: December 2023

Aims: It was aimed to determine the prevalence of lumbosacral anomalies in young male population.
Methods: 56.798 male patients, between 18-49 years old, were included in this study during their medical screening in Dışkapı Yıldırım Beyazıt Training and Research Hospital from July 2016-July 2020. The presence of spina bifida occulta (SBO) and transitional vertebrae (TV) anomalies were recorded in the candidates. SBO patients were evaluated according to their S1 and L5 origins, and TV patients were evaluated separately according to sacralization and lumbarization. We identified transitional vertebrae by counting down from the last thoracic vertebra on the AP X-rays, then if necessary looking at the lateral view for confirmation. If hypoplastic ribs were identified, the vertebra immediately beneath would be designated as L1. Castellvi types I, II, III, and IV were included as transitional states.
Results: 56798 patients were evaluated retrospectively. The mean age of the patients was 23.28 (18-49 years). Radiological anomalies were detected in 2577 (4.5%) of 56798 cases. No radiological anomaly was observed in other cases. Spina bifida occulta was detected in 1478 (2,6%) patients. Lumbosacral transitional vertebrae were detected in 1099 cases (1.9%). 745 (1.3%) of these anomalies are sacralization and 354 (0.6%) of them are lumbalization.
Conclusion: In the light of this information, we think that knowing the frequency of lumbosacral anomalies, especially LSVT, in our society should be considered in the evaluation before spinal surgery operations.
Relationship Geographical Access and Maternal Mortality: Spatial Analysis
Authors: Musafaah Musafaah , Pujianti Nita , Noor Meitria Syahadatina , Lasari Hadrianti Haji Darise , Maulidah Siti 
Published: December 2023

AIM: Banjar District is included in the top 3 of highest maternal mortality rates in South Kalimantan, Indonesia. The purpose of the study is to analyze the relationship between accessibility (distance, time, and transportation) with the incidence of maternal mortality in Banjar District.
METHODS: The study is an observational analysis using a case–control approach with a retrospective. The population was mothers who gave birth in the Banjar district on January 2015−December 2018. Criteria for inclusion of cases are mothers who experience death during pregnancy, childbirth or within 42 days before the end of the pregnancy period recorded in 2015−2018 at the Health Office and births at health facilities in Banjar District, which is represented by the family who knows the best about the mother’s condition, while controls are respondents who do not died in the same year. Sample for case group is 25, by taking the comparison case: control 1:2, then, the sample size of the control group is 50. Statistical test uses Chi-square test.
RESULTS: The results show that there is the relationship between transportation (p = 0.034) and distance (p = 0.035) with the incidence of maternal mortality with Odds ratio (OR) 3.58 and 3.27. However, there is no relationship between time (p = 0.118) with the mortality of maternal.
CONCLUSION: Increasing the accessibility of health services can reduce maternal mortality, one of which is the provision of transportation to bring mothers closer to health facilities.
Les espaces de coworking : un levier de régénération des territoires en dehors des métropoles ?
Authors: Leducq Divya 
Published: December 2023

La diffusion géographique des espaces de coworking (ECW) soulève la question des apports possibles de ces nouveaux lieux à des espaces non métropolitains. Les ECW sont-ils en mesure de contribuer à la résilience architecturale, économique et sociale des territoires « périphériques » ? Quels rôles les différents acteurs du coworking – créateurs-managers, usagers et collectivités territoriales – jouent-ils dans cette possible revitalisation ? Notre hypothèse est que l’apparition de ces nouveaux lieux peut contribuer à la revitalisation des territoires hors-métropoles, mais que parallèlement cette contribution reste marginale et proportionnelle à la taille et l’ancienneté de l’ECW. Trois pistes de cette revitalisation sont pointées : la réhabilitation des bâtiments et friches, la contribution au développement du tissu économique local et enfin les liens sociaux et communautaires engendrés par la présence d’un ECW.
Le tiers-lieu : un nouvel avatar du développement territorial ?
Authors: Moyart Laurence , Pecqueur Bernard 
Published: December 2023

L’émergence des tiers-lieux (TL) est un phénomène rapide et récent bien que le concept soit né aux États-Unis il y a plus de trente ans. Il s’inscrit dans un processus historique long d’apparition de système productifs localisés (SPL), soit d’inspiration italienne avec les districts industriels (DI), soit d’inspiration américaine sur le modèle des clusters. Ces structures nées des années 1970-1980 constituent un premier tournant territorial. L’avènement des TL en grand nombre porte des enjeux forts et fait suite au cumul de plusieurs facteurs à dimension mondiale (accélération de la crise climatique, crise financière de 2008, crise sanitaire depuis 2019). Ces évènements inaugurent, après une période d’approfondissement de la mondialisation, un deuxième tournant territorial. Le premier tournant a été dominé par la forme DI ou SPL, le deuxième semble s’inaugurer autour d’une forme voisine mais pas identique d’intégration systémique, production et consommation, de type TL. Celui-ci serait l’avatar le plus récent du développement territorial. L’article montre que l’industrie wallonne, très tributaire du modèle fordiste en déclin, n’a pas vraiment pris le premier virage mais, avec la réalisation du plan Creative Wallonia , s’engage depuis une dizaine d’années dans ce deuxième tournant environnemental et sociétal.
Taxonomic revision and molecular phylogeny of Pisa (Decapoda: Majoidea: Epialtidae), including the description of a new genus of Pisinae
Authors: Muñoz Isabel , García-Raso J. Enrique , Gónzalez José A. , Lopes Evandro P. , Dos Santos António M. , Cuesta Jose A. 
Published: December 2023

The spider crabs of the genus Pisa Leach, 1814 (Epialtidae: Pisinae) are reviewed in this study based on morphological and molecular data (16S and COI genes). From these results, a new genus, Afropisa n. gen., is established for the clade composed of Pisa carinimana Miers, 1879, Pisa calva Forest and Guinot, 1966 and Pisa sanctaehelenae Chace, 1966 based on carapace morphology, rostrum, pterygostomian tubercles and male gonopod 1. Additionally, Lissa chiragra (Fabricius, 1775) is transferred to Pisa based on morphological (adults and larvae) and molecular evidence. Furthermore, the status of Pisa hirticornis (Herbst, 1804) is discussed and clarified. The phylogenetic relationships between several Pisinae Dana, 1851 genera, as revealed by molecular data, are discussed. An illustrated identification key of eastern Atlantic and Mediterranean species of Pisinae is provided.
Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury - A Meta-Analysis of Randomized Controlled Trials
Authors: Zhang Qiang , Li Yuhuan , Chang Xiaozan 
Published: December 2023

Background:Traumatic brain injury (TBI) is a serious medical condition that often leads to significant morbidity and mortality. Decompressive craniectomy (DC) is now widely recognized as a primary or secondary treatment option for managing intracranial pressure (ICP) in patients with severe TBI. However, there is a lack of clarity in reviews regarding the impact of DC on TBI outcomes.Objectives:The aim of this study is to evaluate the effectiveness of DC in terms of overall mortality and long-term prognosis among patients with TBI.Materials and Methods:We conducted a systematic search of four common databases to include all parallel-arm randomized controlled trials (RCTs). We selected studies that reported outcomes for TBI cases, with DC as a treatment option. The outcomes examined included reduction in mortality, ICP levels, and the proportion of patients with a Glasgow Outcome Scale score >4.Results:Our review finally included eight RCTs [n= 1458, with 749 and 709 patients in the DC and control groups, respectively]. The weighted mean difference for ICP was estimated at -4.01 (95% Confidence interval [CI]: -5.31–-2.71), indicating a statistically significant reduction in ICP levels in the DC group compared to the control group. The pooled risk ratio was 0.67 (95% CI: 0.51–0.89), suggesting a statistically significant 31% decrease in mortality levels in the DC group. Subgroup and sensitivity analyzes were also conducted to address heterogeneity.Discussion and Conclusion:In conclusion, based on our meta-analysis, we find that DC can be considered a crucial surgical intervention for reducing mortality among patients with TBI when compared to control groups.
An Unusual Presentation of an Ectopic Mandibular Third Molar in the Condylar Region: A Case Report and Review of Literature
Authors: Patel Hiren , Pandya Haren , Dewan Hitesh , Bhavsar Bijal , Shah Urvi , Makwana Parth 
Published: December 2023

Abstract

Rationale:
Ectopic teeth arise from developmental abnormalities, pathological conditions or iatrogenic factors. They can be supernumerary, deciduous or permanent and cause dental and facial pain, swelling and infection. Limited cases reveal limited knowledge about causes, symptoms, treatment options and surgical procedures. A thorough evaluation, including radiographic imaging and clinical examination, aids diagnosis and treatment planning.

Patient Concern:
A 54-year-old female patient complains of tooth mobility in the upper right back tooth region for one month and occasional pain in the right pre-auricular region.

Diagnosis:
Chronic generalised periodontitis with an impacted tooth in the right condylar region.

Intervention:
Extraction of Grade III mobile 17 and conservative treatment for ectopic molar in the condylar region.

Outcome:
The patient is on regular follow-up with no similar complaints.

Take-Away Lesson:
A personalised approach is crucial in managing ectopic mandibular third molars and should take into account the patient’s symptoms, preferences and potential complications. Successful treatment requires informed decision-making and thorough evaluation.
Microvascularized Fibular Bone Grafting for the Treatment of Mandibular Expansive Osseous Dysplasia - A Case Report
Authors: Barbeiro Camila de Oliveira , Verzola Mario Henrique Arruda , Barbeiro Roberto Henrique , Tachibana Wilson Tadao , León Jorge Esquiche , Bufalino Andreia 
Published: December 2023

Abstract

Rationale:
Osseous dysplasia (OD) is a benign fibro-osseous lesion classified as periapical, focal or florid with some rare cases being diagnosed as expansive OD.

Patient Concerns:
A 43-year-old female presented with gross mandible expansion and tooth displacement.

Diagnosis:
Imaging scans revealed an expansive lesion in the anterior mandible, with varying opacity in the central region, and other smaller lesions in the region of teeth #37 and #47, consistent with expansive OD.

Treatment:
Surgical resection followed by immediate reconstruction of the mandibular defect using a microvascularized fibular graft.

Outcomes:
The patient had a 4-year follow-up, with adequate mandibular bone continuity, mastication, swallowing, and speaking ability reestablished.

Take-away Lessons:
Immediate reconstruction after large surgical resection is required as tissues retract over time, hampering late reconstructions. Microvascularized fibular graft aims at adequate and functional rehabilitation with osseointegrated implants and long-term follow-up is needed as florid OD may evolve into expansive OD.
Self-introduction of an electric wire into the urinary bladder
Authors: Huda Noushim Akram , Maiti Krishnendu 
Published: December 2023

Abstract
The bladder is the most common site of foreign bodies in the urinary tract. We are presenting a case of a 39-year-old male who self-introduced an electrical wire into bladder. The wire was removed by suprapubic cystotomy after failed endoscopic retrieval. The case is presented for its rarity, along with a review of the literature.