bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Days of the Week and Intraocular Pressure: Japan Ningen Dock Study
Authors: Terauchi Ryo , Wada Takashi , Fukai Kota , Tatemichi Masayuki , Sano Kei , Nishijima Euido , Ogawa Shumpei , Noro Takahiko , Ito Kyoko , Kato Tomohiro , Kato Kiminori , Nakano Tadashi 
Published: November 2023

Précis:
The analysis of intraocular pressure (IOP) by day of the week using the mega database showed a periodic weekly pattern with the highest value on Monday.

Purpose:
To evaluate IOP by the day of the week.

Patients and Methods:
Annual health checkup examinees between April 2014 and March 2015 were cross-sectionally evaluated. As a result, 655,818 participants [51.5±10.5 (range: 20–96) years, 40.1% women] from 103 medical centers were included. IOP was measured using a noncontact tonometer. The mean IOPs of each day of the week were compared using multiple comparison test and multiple linear regression analysis. Wednesday was set as the reference. Moreover, weekly IOP variations stratified by sex and age were also evaluated.

Results:
Mean IOPs from Monday to Sunday were 13.19±2.97, 13.06±2.92, 13.05±2.91, 13.05±2.92, 13.12±2.94, 13.10±2.96, and 13.16±2.78 mm Hg. IOP was significantly higher on Monday, Friday, and Saturday than those on Wednesday (P<0.001, <0.001, 0.002). After adjusting for factors affecting IOP, the IOPs on Monday and Saturday were higher than those on Wednesday [β=0.097 (95% CI: 0.074–0.121), P<0.001; β=0.032 (95% CI: 0.005–0.059), P=0.019]. Men had significantly higher IOPs on Monday and Saturday than on Wednesday [β=0.142 (95% CI: 0.110–0.173), P<0.001; β=0.053 (95% CI: 0.017–0.089), P=0.004], whereas women did not have a significant trend. Participants aged below 65 years had higher IOPs on Monday (P<0.001 in under 60 years; P=0.003 in 60–64 years), while those aged 65 years or older did not (P=0.856).

Conclusion:
IOP values may have a periodic weekly pattern. The high IOP on Monday was more pronounced in men aged less than 65 years.
Apoptotic Marker Expression of Resected Lacrimal Gland Adenoid Cystic Carcinoma Tumor Margins After Intra-arterial Chemotherapy and Globe-Sparing Excision
Authors: Shoji Marissa K. , Moeyersoms Acadia H. M. , Wang Qikai , Gonzalez Hernandez Laura , Tang Vincent D. , Khzam Rayan Abou , Dubovy Sander R. , Pelaez Daniel , Tse David T. 
Published: November 2023

Purpose:
Lacrimal gland adenoid cystic carcinoma (LGACC) is a rare orbital malignancy with devastating lethality. Neoadjuvant intra-arterial chemotherapy (IACC) has demonstrated cytoreductive effects on LGACC macroscopically, but limited studies have examined cellular and molecular determinants of the cytoreductive effect. This post hoc study assessed apoptotic marker expression on excised tumor specimens after neoadjuvant IACC and globe-sparing resection, emphasizing the examination of tumor margins.

Methods:
This retrospective study identified LGACC specimens resected in a globe-sparing technique after neoadjuvant IACC by reviewing the Florida Lions Ocular Pathology database at Bascom Palmer Eye Institute. Histopathology slides of the specimens were re-examined to confirm the diagnosis and identify the tumor margin. Immunofluorescent staining was performed for apoptotic markers, including P53, cleaved caspase-3, cleaved PARP-1, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Positive expression was determined by comparison to the negative control.

Results:
Tumor specimens from 5 patients met inclusion criteria. All 5 cases were positive at the center and the margin for TUNEL, p53, and cleaved caspase-3. One case did not show positive expression of cleaved PARP-1 at the margin but was positive for the other apoptotic markers.

Conclusions:
This post hoc study demonstrated positive staining for multiple apoptotic markers in post-IACC tumor specimens at the tumor center and margin. Apoptotic marker expression along the margins of post-treatment specimens is important, as it may offer surrogate information to speculate on the state of residual cancer cells adjacent to the excision margin inadvertently remaining in the orbit.
Optimizing Ophthalmology Patient Education via ChatBot-Generated Materials: Readability Analysis of AI-Generated Patient Education Materials and The American Society of Ophthalmic Plastic and Reconstructive Surgery Patient Brochures
Authors: Eid Kevin , Eid Alen , Wang Diane , Raiker Rahul S. , Chen Stephen , Nguyen John 
Published: November 2023

Purpose:
This study aims to compare the readability of patient education materials (PEM) of the American Society of Ophthalmic Plastic and Reconstructive Surgery to that of PEMs generated by the AI-chat bots ChatGPT and Google Bard.

Methods:
PEMs on 16 common American Society of Ophthalmic Plastic and Reconstructive Surgery topics were generated by 2 AI models, ChatGPT 4.0 and Google Bard, with and without a 6th-grade reading level prompt modifier. The PEMs were analyzed using 7 readability metrics: Flesch Reading Ease Score, Gunning Fog Index, Flesch-Kincaid Grade Level, Coleman–Liau Index, Simple Measure of Gobbledygook Index Score, Automated Readability Index, and Linsear Write Readability Score. Each AI-generated PEM was compared with the equivalent American Society of Ophthalmic Plastic and Reconstructive Surgery PEM.

Results:
Across all readability indices, PEM generated by ChatGPT 4.0 consistently had the highest readability scores, indicating that the material generated by this AI chatbot may be most difficult to read in its unprompted form (Flesch Reading Ease Score: 36.5; Simple Measure of Gobbledygook: 14.7). Google’s Bard was able to generate content that was easier to read than both the American Society of Ophthalmic Plastic and Reconstructive Surgery and ChatGPT 4.0 (Flesch Reading Ease Score: 52.3; Simple Measure of Gobbledygook: 12.7). When prompted to produce PEM at a 6th-grade reading level, both ChatGPT 4.0 and Bard were able to significantly improve in their readability scores, with prompted ChatGPT 4.0 being able to consistently generate content that was easier to read (Flesch Reading Ease Score: 67.9, Simple Measure of Gobbledygook: 10.2).

Conclusion:
This study suggests that AI tools, when guided by appropriate prompts, can generate accessible and comprehensible PEMs in the field of ophthalmic plastic and reconstructive surgeries, balancing readability with the complexity of the necessary information.
Oral Sedation Anesthesia Protocol for In-Office Oculoplastic Surgery
Authors: Conger Jordan R. , Manipud Nickolas , Elhalouti Ichrak , Lo Christopher , Wang Yao , Burnstine Michael A. , Dresner Steven C. , Samimi David B. 
Published: November 2023

Purpose:
To present an oral anesthesia protocol for in-office oculoplastic surgery and to compare safety outcomes and patient and physician experiences to ambulatory surgery center (ASC)-based surgery with intravenous sedation or general anesthesia.

Methods:
A prospective study was performed on consecutive patients undergoing surgery at an oculofacial plastic surgery practice. Surgery was performed in an in-office setting using our standardized oral sedation protocol or at an ASC with intravenous sedation or general anesthesia. Preoperative and postoperative surveys were conducted by patients and physicians to compare surgical experience, safety, and efficacy of our oral sedation protocol for in-office surgery in the ASC setting.

Results:
Two hundred and fifty-three patients (167 in-office and 86 at ASC) underwent surgery between March and November 2022. There was no significant difference in how patients or physicians rated their experience between the 2 locations. A significantly higher proportion of ASC patients would have rather had surgery in-office (34.9% vs. 19.2%; p = 0.006). A significantly higher number of physicians in the office setting would have rather performed surgery at the ASC than the reverse (12.7% vs. 2.3%, respectfully; p = 0.007). There were no safety complications reported in either setting.

Conclusions:
Within our patient cohort, the presented oral sedation protocol provided safe and effective anesthesia for in-office oculoplastic surgery that is comparable to an ASC.
Transient Postinflammatory Hyperpigmentation Following Eyelid Surgery
Authors: Gutovitz Joel M. , Ben-Simon Guy , Egozi Ella , Bar Ariel , Landau Prat Daphna 
Published: November 2023

Purpose:
The authors’ aim was to describe a rare mild complication of eyelid surgery presenting as transient hyperpigmentation along the suture lines.

Methods:
A retrospective case series of 6 patients experiencing transient hyperpigmentation following eyelid surgery. Each patient underwent either blepharoplasty alone or blepharoplasty with ptosis repair utilizing Müller muscle conjunctival resection. Data including surgery type, hyperpigmentation laterality and location, time to diagnosis, follow-up time, and outcome were assessed.

Results:
All 6 patients with hyperpigmentation were females. All patients underwent blepharoplasty, including 1 upper eyelid blepharoplasty and 4 with both upper and lower eyelid blepharoplasty. One patient underwent bilateral upper blepharoplasty with concurrent posterior approach ptosis surgery repair of the left upper eyelid. Hyperpigmentation was bilateral in all 5 blepharoplasty cases and unilateral in the ptosis repair case. Hyperpigmentation included the medial portion of the operated upper eyelid in all cases. Time to diagnosis ranged from 1 to 4 weeks postoperatively, and follow-up time ranged from 3 to 5 months. Management was conservative in all cases. Five patients experienced complete resolution, and 1 patient experienced near-complete resolution on a 3-month follow-up.

Conclusions:
Transient hyperpigmentation is a rare posteyelid surgery complication, generally with an excellent outcome not requiring additional intervention.
Clinical management of a nonoptimal vault and unexpected postoperative refraction in a patient implanted with a phakic intraocular lens
Authors: Sánchez-Trancón Angel , Baptista António Manuel , Sierra Oscar Torrado , Serra Pedro Miguel 
Published: November 2023

Introduction:
This case reports the management of a bilateral toric implantable collamer lens (ICL) surgery with low vaulting and unilateral reduction in visual acuity (VA) associated with a combined effect of surgically induced astigmatism (SIA) and toric-ICL rotation. This case expands the common management of toric-ICL rotation, by adding surgically induced corneal changes.

Patient and Clinical Findings:
The patient presented with moderate myopia and high astigmatism and was implanted with a toric-ICL, resulting in bilateral low vault <150 μm and unilateral VA reduction (20/40) because of postoperative oblique astigmatism, observed at the 4-week follow-up.

Diagnosis, Intervention and Outcomes:
The low ICL vaulting was associated with a high crystalline lens rise and underestimation of the sulcus-to-sulcus distance. The VA reduction resulted from a combined effect of ∼1.0 diopter SIA and 8-degree ICL rotation. The authors associate the high SIA to abnormal corneal biomechanics indexes and the toric-ICL rotation to a lack of stability resultant from a small ICL size. The left eye toric-ICL has exchanged with one with larger size and the power recalculated using vectorial analysis. The toric-ICL exchange increased the vault 75 μm and improved VA.

Conclusions:
Detailed anterior chamber morphometry and corneal biomechanics may assist in improving the refractive outcome in toric-ICL surgery.
Photodynamic Therapy for Treatment of Actinic Keratosis in a Patient With Graft Versus Host Disease
Authors: Sobotka Michelle Hook , Stover Kim Carlson 
Published: November 2023

ABSTRACT
Photodynamic therapy, consisting of aminolevulinic acid and blue light in combination, is a treatment option for diffuse actinic keratosis in patients with cutaneous manifestations of graft-versus-host disease resulting from an allogenic stem cell transplantation for lymphoma. Different treatment options, such as imiquimod and 5-fluorouracil, are effective treatment options in the general population, but risk flaring graft-versus-host disease in patients with this condition. We present a case where photodynamic therapy was successfully used in the treatment of actinic keratosis for a patient with chronic graft-versus-host disease without flaring the cutaneous manifestations of graft-versus-host disease.
Measuring Sexual and Gender-Based Violence at the University of Cape Coast
Authors: Compton Sarah D. , Odoi Amanda , Dickson Kwamena , Darteh Eugene K. M. , Munro-Kramer Michelle L. 
Published: November 2023

ABSTRACT

Aims
Sexual and gender-based violence (SGBV) is a global public health crisis, impacting university youth around the world. The purpose of this study was twofold: (a) determine the best methodology for conducting a campus climate survey at the University of Cape Coast (UCC) in Ghana and (b) gather data on SGBV knowledge, attitudes, and behaviors from a representative sample of students.

Methods
This descriptive study included three phases: (a) develop a campus climate survey unique to UCC, (b) develop a sampling methodology, and (c) deploy the first ever campus climate survey at UCC.

Results
A 71-item survey was developed and then administered via a student portal to 2,000 students. Of those students, 1,381 (69.1%) responded. Although most students (63.2%) know the university has a sexual harassment policy, fewer have seen it (25.9%) or read it (22.3%). Students held generally positive views of how the university would respond to reports of sexual harassment, although 50.2% of participants believed the reporter would be labeled a troublemaker. More participants reported seeking and giving verbal than nonverbal consent, and more men than women reported both seeking and giving verbal consent. More men than women reported they “always” sought verbal consent (61.2% vs. 47.7%, p = 0.001). Most students (n = 316, 56.5%) sought verbal consent all of the time, and an additional 99 (17.7%) sought it most of the time.

Conclusions
Accurate data about students' knowledge, attitudes, and experiences with SGBV policy, prevention, and response are needed globally to better inform locally appropriate practices.

Potential Impact of Campus Intimate Partner Violence and Sexual Assault on Forensic Nursing
Forensic nursing is currently localized in high-income countries. University students' knowledge, attitudes, and experiences with SGBV can support the expansion of forensic nursing research and practice to low- and middle-income countries.
Bladder pain syndrome AKA interstitial cystitis – a condition with severe unmet medical need: an exploration of brimapitide as a potential treatment opportunity
Authors: Taubert Erich , van der Aa Frank , Heesakkers John 
Published: November 2023

Purpose of review
The purpose of this article is to present recent findings of KU002 (brimapitide) as a novel treatment option for interstitial cystitis/bladder pain syndrome (IC/BPS).

Recent findings
IC/BPS is a complex and poorly understood heterogeneous syndrome, with many burdensome symptoms that severely affect patients’ quality of life. Treatment options beyond conservative and nonpharmacologic approaches remain limited, and there is an unmet medical need for effective medical treatments. While there are multiple ongoing clinical trials in this area, only a few explore new treatment options. This article summarizes current ongoing development and reports the findings of one such trial.

Summary
In a phase 1/2a exploratory trial, intravesical instillation of brimapitide confirmed local action while eliciting in minimal systemic exposure, resulting in a promising and favorable safety profile. Efficacy exploration suggests that brimapitide reduces pain, improves signs and symptoms of IC/BPS and improves the general wellbeing of the study participants.
Secondary central retinal artery occlusion due to rhino-orbital-cerebral mucormycosis in a diabetic patient: a case report
Authors: Sumual Vera , Lukandy Andry , Sutanto Reynardi Larope 
Published: November 2023

Introduction and importance:
Acute sinusitis can cause intraorbital complications. Although subperiosteal abscesses generally do not cause severe vision loss, rare cases of decreased vision due to central artery or vein occlusion have been reported since 2003. Central retinal artery occlusion (CRAO) is an eye emergency that can cause sudden loss of vision. This condition is commonly found in elderly individuals with other metabolic diseases. The authors report a case of a type 2 diabetes mellitus (T2DM) patient with CRAO due to suspected rhino-orbital-cerebral mucormycosis (ROCM).

Case presentation:
A 47-year-old man came with sudden blurred vision since the last week. Examination of the left eye revealed no light perception and vision, orthophoric eyeball position with restricted movement in all directions. Hypaesthesia was observed on the left side of the face. In the anterior segment, oedema of the eyelids, ptosis, conjunctival injection, ciliary injection and chemosis, clear cornea, deep anterior chamber with VH4, brown iris, crypts, no neovascularization of the iris, pupil round, mid-dilated with a diameter of 5 mm, no light reflex, relative afferent papillary defect, and NO2NC2 lens were observed. In the posterior segment, non-uniform fundal reflexes were found, as well as retinal oedema, round papillae, hyperaemic fovea reflex (cherry-red spot), and a cup-to-disc ratio that could not be evaluated. The patient was diagnosed with CRAO, orbital cellulitis, and uncontrolled T2DM. The patient was administered topical and oral antibiotics; however, there was no improvement in the left eye. ROCM was suspected.

Clinical discussion:
CRAO is most often caused by embolization or thrombosis associated with atherosclerosis at the lamina cribrosa level. CRAO accompanied by ROCM infection is very rare; to establish the diagnosis, it is necessary to carry out further examinations so that administered therapy can definitely improve the patient’s clinical condition. Due to resource limitation, biopsy and MRI were not performed. Surgical debridement was planned when the patient was stable, but the patient missed follow-up appointments.

Conclusion:
Fungal aetiology should be considered especially in T2DM patient with CRAO that do not improve with antibiotics.
Changes in Pelvic Floor Symptoms After Procedural Interventions for Uterine Leiomyomas, A Systematic Review
Authors: Gupta Ankita , Balk Ethan M. , Lenger Stacy M. , Yang Linda C. , Misal Meenal , Balgobin Sunil , Chang Olivia H. , Sharma Vidya , Stuparich Mallory , Behbehani Sadikah , Nihira Mikio , Alas Alexandriah , Jampa Alekhya , Sheyn David , Meriwether Kate , Antosh Danielle D. 
Published: November 2023

(Abstracted from Obstet Gynecol 2023;142:319–329)
Uterine leiomyomas are the most prevalent benign uterine tumors with a cumulative incidence of 70% to 80% by age 50 years. Up to 70% of women with leiomyomas are asymptomatic and require no treatment, but among symptomatic women, heavy or prolonged menstrual bleeding, bulk-related symptoms, dysmenorrhea, sexual dysfunction, and adverse pregnancy outcomes are common.
Unexpected Symmetrical Uptake of 18F-FDG of Distal Peripheral Bones in a Patient With Diffuse Large B-Cell Lymphoma
Authors: Güneren Cansu , Şahin Kübra , Sönmezoğlu Kerim 
Published: November 2023

Abstract
A 74-year-old woman was referred for 18F-FDG PET/CT scanning to investigate an underlining etiology due to recently developed unexplained bone pains and lack of walking capacity. On the initial PET/CT scan, we have noted a highly symmetrical and apparent intramedullary FDG uptake of the distal parts of appendicular skeleton system including the bilateral elbows, wrists, and foot ankles in addition to a lymphadenomegaly in the right groin. The excisional biopsy from the lymph node of right groin revealed a diagnosis of diffuse large B-cell lymphoma.
Elevated 68Ga-FAPI-04 Activity Due to Staphylococcus aureus Intracranial Infection
Authors: Zhang Zeyu , Hou Wenli , Pan Guixia , Zuo Changjing , Cheng Chao 
Published: November 2023

Abstract
A 37-year-old man was admitted to our hospital after experiencing syncope. An MRI of his head revealed multiple foci of abnormal signal, which could potentially be metastases. The patient then underwent a 68Ga-FAPI-04 PET/MRI examination, which revealed multiple FAPI-avid foci in the brain. Upon analyzing the cerebrospinal fluid, it was found that the patient had a Staphylococcus aureus infection. The results suggest that 68Ga-FAPI-04 PET has the potential to be a valuable tool in the visualization of intracranial infectious lesions.
‘I Did No Harm’
Authors: Desouky Elsayed , Ibrahim Mohamed. , Sharma Harbinder. , Jallad Samer 
Published: November 2023

Objective:
To assess the performance of our urology team against GMC guidelines for using chaperone during intimate clinical examination.

Background data:
intimate physical examination is an integral part of our urological practice. There is a paucity of literature regarding the use of chaperones among urologists. Given the importance of this topic for both patient safety and providing support for the urologist, we decided to assess our performance as per the GMC guidelines for good medical practice.

Methods:
We completed an audit loop to evaluate the performance of 12 members in our urology team as regards compliance with GMC guidance for the documentation of chaperone use in urology clinic. Based on our scoring system, we objectively assessed both overall team performance as well as individual scores for documenting chaperone use.

Results:
There was a significant improvement in the overall documentation rate in both clinical notes (+9.85%) and clinic letters (+36.65%). Raising awareness among team members managed to increase the individual performance scores as well.

Conclusion:
This is the first report using a scoring system for objective assessment of a pertinent topic such as the use of chaperone and its documentation. This managed to achieve a significant improvement in our practice.
A new minimally invasive, nonexcisional, surgical browlift technique with minimal scarring: a protocol for a prospective observational study
Authors: de Jongh Frank W. , Kooiman Laurens B.R. , Sanches Elijah E. , Pouwels Sjaak , Ingels Koen J.A.O. , Wehrens Kim M.E. , Tan Liang T. 
Published: November 2023

Background:
The aim of this study is to prospectively evaluate the new minimal invasive (MINE) browlift technique with possibly superior results and minimal visible scarring.

Study design:
A prospective observational study will be performed on all available data from patients who will undergo a browlift procedure in the HMC from 1 June 2021 till 31 May 2024. Our goal is to include at least 50 patients. Inclusion criteria are: patients with medical (i.e. brow ptosis and facial paralysis) or cosmetic indication, patients with sufficient understanding of the Dutch or English language and willingness to participate in extra study specific follow-up moments and filling in of questionnaires. Exclusion criteria are: less than 18 years of age and patients with previous brow or eyelid surgery. Patients will be photographed preoperatively and postoperatively using the VECTRA camera.

Outcome measurements:
Scarring after procedure; functionality of eyebrow movement; amount of correction in brow ptosis, measured in VECTRA; longevity of procedure in months; aesthetic result as assessed by questionnaires and adverse effects of procedure will be measured.

Ethics and dissemination:
The database management software ʻCastorʼ will be used to store and collect the data from the questionnaire. The Medical Research Ethics Committee found this study not eligible to be submitted to the Dutch Medical Research Involving Human Subjects Acts (WMO). Written consent will be obtained from all patients.