bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-articular Median Nerve Entrapment of the Elbow After Medial Epicondyle Fracture
Authors: Rausch Valentin , Pätzholz Simon , Königshausen Matthias , Schildhauer Thomas A. , Gessmann Jan 
Published: January 2025

Case:
We describe a 13-year-old adolescent girl experiencing persistent pain and reduced grip strength following nonoperative treatment of a medial epicondyle fracture-dislocation with closed reduction over 5 years before her referral to our clinic. Neurological examination and magnetic resonance imaging of the elbow revealed damage to the median nerve due to an entrapment within the elbow. Surgical release of the nerve resulted in complete pain relief and improved neurological function with normalized nerve conduction.

Conclusion:
Persistent neurologic deficits should be investigated following pediatric elbow trauma. Promising results can be achieved with surgical treatment even after long-term entrapment of the median nerve.
Tetrafocal Bone Lengthening by Ilizarov Frame Application in a Patient With Segmental Tibial Bone Loss
Authors: Mohib Yasir , Ali Usman , Mariam Fizzah , Slote Muhammad Bilal Raza , Ali Ziad , Rashid Haroon ur 
Published: January 2025

Case:
Thirty-five-year-old man presented with 14 cm segmental tibial defect after crush injury (Gustilo Anderson type-IIIA). Tetrafocal bone transport using Ilizarov frame was performed with 3 osteotomies. Two minor complications—skin invagination and failure at proximal docking site—were addressed. At 18 months, patient exhibited excellent functional outcomes with full range of motion and no signs of limb length discrepancy, infection, or nonunion.

Conclusion:
This case highlights the potential of tetrafocal bone transport as an effective treatment for segmental tibial defects, even in resource-limited settings, demonstrating that complex orthopedic challenges can achieve excellent outcomes with proper technique and care.
The Utilization of MRI-Generated Synthetic CT in the Treatment of Chronic Bilateral Spondylolysis
Authors: Michael George , Etigunta Suhas K. , Liu Andy M. , Watterson Christopher , Skaggs David L. , Illingworth Kenneth D. 
Published: January 2025

Case:
A 14-year-old male athlete presented with a 9-month history of low back pain, worse with hyperextension. Nonoperative management for bilateral L4 spondylolysis had been unsuccessful. The patient underwent a novel magnetic resonance imaging (MRI) that generated a synthetic computed tomography (sCT). MRI/sCT revealed nonunion of the spondylolysis with persistent edema. The patient underwent minimally invasive bilateral L4 robot-navigated intralaminar screw fixation. CT at 3 months demonstrated complete healing.

Conclusion:
This case is the first to document the use of MRI-generated sCT in the management of pediatric spondylolysis, offering improved assessment of both bony and soft tissue pathology in a single study without the ionizing radiation of traditional CT.
Paleoenvironmental conditions and evolution of a muddy turbidite system: an integrated sedimentological and ichnological analysis
Authors: Cabrera-Ortiz José F. , Dorador Javier , Rodríguez-Tovar Francisco J. , Pérez-Asensio José N. 
Published: January 2025

Abstract
Recent advances in characterization of turbidite-fans have been achieved through various methodologies, including flume-tank experiments, numerical modeling, seismic analysis, and integrated core and outcrop studies. Ichnology has proven valuable for understanding turbidite systems by providing insights into paleoenvironmental conditions such as oxygen levels, nutrient availability, hydrodynamic energy, and sedimentation rates. Since the 1960s, the Nereites ichnofacies has been linked to flysch deposits, characterized by features such as graphoglyptids, shallow-tier ichnotaxa, complex grazing trails, and diverse, but low density, trace fossils. The aim of this study is to combine ichnological and sedimentological data to improve recognition of subenvironments in turbidite systems. Analysis of five sections in a late Miocene, muddy turbidite system in the Tabernas Basin (SE Spain) shows that: 1) the distal fan lobes are characterized by a high diversity and abundance of predepositional trace fossils linked to the Paleodictyon ichnosubfacies, indicating stable and oligotrophic conditions, and 2) the proximal fan lobes by a low diversity and abundance of postdepositional trace fossils with abundant Ophiomorpha rudis ichnosubfacies in areas close to the feeder channel.
WITHDRAWN: Algorithm Development for Measuring CDOM and Secchi from Hue Angle Using Satellite Images: A Study in Lake Peipsi, Estonia
Authors: Rahman Mizanur , Alikas Krista , Ansper-Toomsalu Ave , Aunap Raivo 
Published: January 2025

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: Cognitive behavioural therapy improves sleep quality in nursing students: results from a randomized controlled trial
Authors: Perez-Manchon David , Azpeleta-Noriega Clara , Gal-Iglesias Beatriz , Ruiz-Zaldibar Cayetana 
Published: January 2025

Abstract

Background
Sleep quality is a strategic public health priority and is the key factor in studying circadian rhythms and their chronotypes. University students are a particularly vulnerable population group. The objective of the research is to show the impact of an intervention aimed at improving sleep quality among first-year academic nursing students.
Methods
The study is a two-arm pilot randomized clinical trial conducted from October 2022 to March 2023. Two groups were randomly assigned to an experimental group (n = 20) that received a cognitive behavioural intervention of active-constructive learning methodology to improve sleep quality and a control group (n = 20) that followed their usual daily routine. In both groups, ambulatory circadian monitoring was carried out over a period of 7 days, and Pittsburgh Sleep Quality index questionnaire was administered, pre- and post-intervention. Satisfaction was assessed in the intervention group at the end of the intervention. This study is performed according to the CONSORT statement.
Results
Of the 40-participant included in the study, 85% were female and 15% male with a mean age of 19.8. After the intervention, circadian parameters of interdaily stability, rhythm regularity and amplitude, and sleep parameters such as less exposure to blue light 2h before bedtime and lower sleep latency improved in the intervention group.
Conclusions
Cognitive behavioural therapy intervention aimed at nursing students has improved the main marker of circadian health robustness and sleep quality, while provoking high degrees of satisfaction in the participants.
Trial and protocol registration
This study has been registered 2022/02/28 at ClinicalTrials.gov with reference number NCT05273086
Analysis of the Correlation Between Pregnancy Complications and Placental Histopathology: A Study of Samples from Shahid Sadoughi Hospital, Yazd, Iran (2013-2022)
Authors: Torki Alireza 
Published: January 2025

Abstract

Aims: This study aimed to investigate the correlation between pregnancy complications and placental histopathology in samples collected at Shahid Sadoughi Hospital in Yazd from 2013 to 2022.
Method: A census sampling approach was utilized to examine all placental samples submitted to the pathology department at Shahid Sadoughi Hospital between 2012 and 2014. Following approval from the Research Council of the Faculty of Medicine at Shahid Sadoughi University of Medical Sciences in Yazd and clearance from the ethics committee, the study commenced. Stakeholders were briefed on the study objectives, methodology, and 15 data confidentiality. Patient records were scrutinized based on predefined criteria, and relevant information was extracted.
Results: The retrospective analysis included 210 subjects with an average age of 28.78±5.51 years. The average gestational age in the sampled cases was 32.98±4.09 weeks. The highest incidence of pregnancy-related pathologies was attributed to IUGR at 20.0% and IUFD at 18.1%. The predominant placental histopathological findings were categorized as no significant abnormalities (26.2%) and multifocal ischemic changes (21.0%).
Conclusion: The study findings establish a significant association between pregnancy complications like IUGR and IUFD and specific placental histopathological patterns. Notably, a substantial proportion of cases exhibited diverse placental histopathologies, particularly those with unremarkable findings and multiple ischemic changes. These results underscore the importance of diligent placental histopathological assessments in the investigation of pregnancy complications, aiding in enhanced clinical decision-making. The study recommends comprehensive placental histopathological evaluations in suspected high-risk pregnancies to improve clinical management strategies
Isolation, Characterization, and Biomedical Potential of Phycoerythrin Phycobiliprotein from Kappaphycus alvarezii (Doty) Doty ex Silva: Antimicrobial, Antioxidant, and Anticancer Activities
Authors: Balasundaram Harinathan , Seethapathy Parthasarathy , Sankaralingam Subbiah , Mahendran Shunmugiah , Mareeswaran Murugan , Pandiarajan Jeyaraj , Maheswari Pandiaraj , Venkatesh Sakthivel , Arunkumar Malaisamy , Pathade Girish R. , Pandita Deepu , Pandita Anu , Ullah Fazal , Elansary Hosam O. , Nazim Muhammad , Fickak Adel A. , Rashwan Mohamed A. , Moussa Ihab Mohamed 
Published: January 2025

Abstract

Kappaphycus alvarezii (Doty) Doty ex Silva, a red seaweed widely cultivated for carrageenan polysaccharide, is also a potential source of the valuable pigment phycoerythrin (PE). Therefore, this study aims to extract phycoerythrin from K. alvarezii, evaluate its antimicrobial, antioxidant, and anticancer activities, and identify its biomedical potential for future therapeutic applications. The protein content of phycoerythrin pigment extracted from K. alvarezii was found to be 69.84% and showed excellent antimicrobial activity against Klebsiella oxytoca and Proteus mirabilis, with a minimum inhibition zone of 11 mm. It showed significant in vitro antioxidant activity, as analyzed using total antioxidant, hydrogen peroxide scavenging, reducing power, DPPH, and ABTS assays. Further, the pigment exhibited potent cytotoxicity against a human lung cancer cell line, with an IC50 value of 131.7 µg mL-1. Furthermore, increasing the concentration of phycoerythrin pigment decreased the cell proliferation and induced apoptosis, as confirmed by Annexin V/PI staining. Comprehensive characterization using FT-IR, HPLC, and GC-MS analysis revealed the nature of pigment and functional groups, highlighting its potential for biomedical applications. The molecular docking of K. alvarezii-derived compounds revealed significant binding affinities with 13 antibacterial target proteins. These results highlight the potential of K. alvarezii bioactive compounds as promising antibacterial agents. The phycoerythrin extract from K. alvarezii demonstrated potent antimicrobial, antioxidant, and anticancer properties, with significant cytotoxicity against lung cancer cells and confirmed apoptosis induction. Structural analysis revealed its bioactive composition, emphasizing its potential as a natural therapeutic agent. These findings support its potential application in biomedical and pharmaceutical industry.
Design and performance analysis of n-MoS 2 /p-Si heterojunction solar cell for emerging optoelectronic applications
Authors: Pradhan Ritishri Priyaranjan , Mishra Sheo Kumar , Singha Monoj Kumar , Kumar Arvind 
Published: January 2025

Abstract

Sustainable, green, clean energy sources based electrical energy conversion is essential to the modern world. A solar cell or photovoltaic cell acts as a major part of that to accomplish the energy interest. Two-dimensional materials such as Molybdenum disulphide (MoS2) based heterojunction solar cells attracted researchers for their extraordinary chemical, physical, thermal, mechanical, optical, and electrical stability. In this work, we simulated the electrical behavior of n-MoS2/p-Si-based heterojunction-based solar cells with the help of the Solar Cell Capacitance Simulator - One Dimensional (SCAPS-1D) simulation tool. We examine the performance of MoS2-based solar cells by varying the active layer’s thickness, which leads to the changing of the band gap variation in the electron affinity, and explore the performance of devices with different metal contacts. The impact of interfacial defect density, series, and shunt resistance is also evaluated on various working temperatures of the devices. The best combinations of different parameters give an efficiency (η) of 12%, which is sufficiently high enough compared to the previously published experimental work. This will provide essential insight into the development of high-performance solar cells with two dimensional (2D) materials.
Bile Leaks Requiring Multiple ERCPs – Risk Factors for Poor Outcomes
Authors: Miller Alexander T. , Dairi Obaida F. , Sogaard Kristian K. , Gardner Timothy B. 
Published: January 2025

Abstract

Introduction: Bile leaks may require intervention with endoscopic retrograde cholangiopancreatography (ERCP). Success rates with ERCP are reported to be over 90%; however, a subset of patients still require multiple ERCPs to achieve resolution. We investigated demographic and interventional factors necessitating multiple ERCPs to achieve bile leak resolution.Methods: We retrospectively reviewed cases from 2014–2024 at our institution that involved bile leaks requiring an ERCP. We categorized leaks into those that required two or less ERCPs for resolution versus those that required three or more ERCPs while examining the demographic and interventional risk factors between the two groups.Results: A total of 143 cases were included in our analyzed sample. 83.2% (n = 119) required two or less ERCPs for resolution while 16.8% (n = 24) required three or more ERCPs until resolution. We did not find a difference between the etiology of the leak or the location when the leak was identifiable; however, we did observe a significantly higher percentage of cases where the leak was not identified in the three or more group compared to the two or less group, 33.33% vs. 14.29% (p = 0.0373). Cases requiring two or less ERCPs more likely used plastic stents, 89.1% vs 66.7% (p = 0.010). Finally, cases requiring three or more ERCPs were more likely managed with a sphincterotomy without stent placement, 12.5% vs 1.7% (p = 0.033).Conclusions: Performing stent placement AND biliary sphincterotomy at time of index ERCP led to more rapid resolution of bile leaks, irrespective of patient characteristics or type of leak.
CPMFD: An algorithm for Classification of Point Mutations together with Frameshift Determination in related mRNA sequences
Authors: Mondal Probir , Banerjee Pratyay , Basuli Krishnendu 
Published: January 2025

Abstract

Mutations are responsible for the genetic origin of various diseases. Existing techniques for mutation identification often fails to detect the full spectrum of mutations in complex genomes hindering progress in diagnosis, treatment and prevention of diseases. Here we propose an algorithm to identify the location
and type of mutation occurring in a mutated string with respect to a reference mRNA sequence. In addition to identifying insertion and deletion, by constructing suitable rational combinations of the prime numbers, our algorithm is able to classify point mutations in a novel way by distinguishing missense mutation from silent mutation. Moreover, the method allows to locate regions in the sequence undergoing frameshift. This algorithm turns out to be efficient when applied on simulated dataset. Application of this framework to two haplotypes of the Plasmodium falciparum datasets exhibit different mutation profile to develop similar chloroquine resistance. We investigate the β-globin genes found in pygmy and common chimpanzee to identify mutations of all sort distinguishing the two species. Additionally, in Alzheimer datasets, our method meticulously identifies true variations in the related genes.
The Role of School Leadership in Improving the Quality Management of Education at SMA Kabupaten Kutai Barat
Authors: Afriyanti  , Radiyah Titi , Azainil  
Published: January 2025

This study aims to analyze the role of school leadership in enhancing the quality management of education at SMAN 2 Linggang Bigung, Kutai Barat Regency. The methodology employed in this research is a qualitative approach with a descriptive design. Data were collected through in-depth interviews, observations, and documentation studies involving the principal, teachers, and representatives of the school committee. The findings indicate that the diversity of leadership styles, such as participative, transformational, and collaborative, significantly contributes to the improvement of educational quality. The strategies implemented, including teacher training, project-based learning, and parental involvement, have had a positive impact on the quality of learning and student motivation.Despite challenges such as budget constraints and resistance from some teachers, the collaborative efforts made by the principal demonstrate great potential for improving educational quality in the region. This research emphasizes the importance of inclusive leadership and adaptive strategies in creating an effective learning environment. The principal should continue to strengthen collaboration with various stakeholders and develop structured training programs for teachers to enhance their competencies in implementing innovative teaching methods. With these measures, it is hoped that SMAN 2 Linggang Bigung can continue to improve educational quality and produce graduates who are ready to compete in the global era.
Keywords: 1st School Leadership, 2nd The Quality Management, 3rd Education, 4th SMA,
Adenocarcinoma of small bowel: why is it so rare
Authors: Medeiros Aldo Cunha Medeiros , Lima Filho Albert Dikson de 
Published: January 2025

Small bowel adenocarcinoma (SBA) is a rare gastrointestinal neoplasm and despite the small intestine's significant surface area, SBA accounts for less than 3% of such tumors. Early detection is challenging and the reason arises from its asymptomatic nature, often leading to late-stage discovery and poor prognosis. Treatment involves chemotherapy with a 5-fluorouracil combination, but the lack of effective chemotherapy contributes to a generally poor prognosis. SBAs are linked to genetic disorders and risk factors, including chronic inflammatory conditions. The unique characteristics of the small bowel, such as rapid cell renewal and an active immune system, contributes to the rarity of these tumors as well as the high intratumoral infiltration of immune cells is associated with a favorable prognosis. Microsatellite instability in SBA is associated with a high tumor mutational burden, affecting the prognosis and response to immunotherapy. The presence of PD-L1 and programmed cell death, along with tumor-infiltrating lymphocytes, plays a crucial role in the complex microenvironment of SBA and contributes to a more favorable prognosis, especially in the context of high MSI tumors. Stromal tumor infiltratinglymphocytes are identified as independent prognostic indicators andthe association between MSI status and a favorable prognosis, emphasizes theimportance of evaluating the immune status of tumors for treatment decisions.
In conclusion, small bowel adenocacinoma is a rare disease, the organ has some caracteristics that contributes to the small incidence of SBA. Finally, the diagnosis, treatmentand survival are challenging.
Pengaruh Sensory Experience, Emotional Experience, Dan Social Experience Terhadap Repurchase Intention
Authors: Marta Tasya , Arif Moh. Erfan 
Published: January 2025

The objective of this research is to identify the effects of sensory experience, emotional experience, and social experience on the repurchase intention of Roda Baru Padang Restaurant’s customers in Malang City. This quantitative explanatory research explains the relationship and effects of variables to others though hypothesis testing. Using non-probability sampling method and purposive sampling technique, 148 people with the minimum age of seventeen years who live in Malang City and have the experience of visiting or dining in Roda Baru Padang Restaurant in Bendungan Sutami Street number 53 at least once in the last three months were selected as the respondents. The research data was analyzed using Partial Least Squares, and the instruments were previously assessed, while the outer and inner models were examined using t-test; all of which were performed in SmartPLS. The testing results on the three hypotheses suggest that sensory experience, emotional experience, and social experience positively and significantly affect the repurchase intention.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh variabel Sensory Experience, Emotional Experience, dan Social Experience terhadap Repurchase Intention pada konsumen Rumah Makan Padang Roda Baru Kota Malang. Jenis penelitian yang digunakan adalah explanatory research dengan pendekatan kuantitatif yang menjelaskan hubungan dan pengaruh antara satu variabel dengan variabel lainnya melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 148 responden yang diambil dari populasi konsumen Rumah Makan Padang Roda Baru Kota Malang. Pengambilan sampel menggunakan teknik non-probability sampling dan pengumpulan data menggunakan kuesioner. Karakteristik sampel yang dipilih yaitu berusia minimal 17 tahun, berdomisili di Kota Malang, pernah mengunjungi dan melakukan pembelian Dine-In di Rumah Makan Padang Roda Baru Jl. Bendungan Sutami No. 53 minimal 1 kali dan dalam kurun waktu 3 bulan terakhir. Analisis data yang digunakan dalam penelitian ini adalah partial least square dengan melakukan uji instrumen serta uji t pada outer dan inner model menggunakan program SmartPLS. Hasil pengujian ketiga hipotesis menunjukkan bahwa sensory experience, emotional experience, dan social experience berpengaruh positif dan signifikan terhadap repurchase intention.