bluuebunny/crossref_metadata_2025_split huggingface dataset:
Podcast Reenactments and the Sonics of Fictionalization from Cher to Swift
Authors: Skjerseth Amy 
Published: November 2023

Podcasts often blend journalistic investigation with personal reflection, from Serial to Switched on Pop. Their veneer of fiction-as-fact especially confounds representation when podcasts’ voice acting and sound design portray pop stars in caricatured dramatizations. This paper examines reenactments of Cher and Taylor Swift in podcasts that investigate popular music industries and technology. As I show, these stars often are ventriloquized on podcasts due to their respective ages and visibility as women. Podcasts interrogate them for being too old or too young and for trespassing onto the often-male domains of business and technology.To show how podcast hosts represent women pop stars in particularly gendered and ageist ways, I listen to the sonics of fictionalization of two episodes that mythologize Cher’s Auto-Tuning and Swift’s battle to take back her masters from record industry men. First, American Innovations reenacts Cher’s request to producers to create the Auto-Tune effect, but the male host’s ventriloquy of her voice reduces her artistic and technological prowess to parody as they make her seem outdated. Then, in Business Wars, multiple voice actors reenact Swift’s career from its beginning and depict her as a child who doesn’t know any better. These podcasts blur facts and public opinion with alluring dramatizations of what “really happened,” placing listeners in the scene with compelling voice acting and ambient sound effects. In these reenactments, podcasts’ affordances of intimacy and immersion—which hosts often herald as democratizing—perpetuate cultural mythologies about gender and age in popular music.
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis
Authors: Mary Benjamin , Asokan Nandini , Jerabkova‐Roda Katerina , Larnicol Annabel , Busnelli Ignacio , Stemmelen Tristan , Pichot Angélique , Molitor Anne , Carapito Raphaël , Lefebvre Olivier , Goetz Jacky G , Hyenne Vincent 
Published: November 2023

AbstractExtracellular vesicles released by tumors (tEVs) disseminate via circulatory networks and promote microenvironmental changes in distant organs favoring metastatic seeding. Despite their abundance in the bloodstream, how hemodynamics affect the function of circulating tEVs remains unsolved. We demonstrated that efficient uptake of tEVs occurs in venous endothelial cells that are subjected to hemodynamics. Low flow regimes observed in veins partially reroute internalized tEVs toward non‐acidic and non‐degradative Rab14‐positive endosomes, at the expense of lysosomes, suggesting that endothelial mechanosensing diverts tEVs from degradation. Subsequently, tEVs promote the expression of pro‐angiogenic transcription factors in low flow‐stimulated endothelial cells and favor vessel sprouting in zebrafish. Altogether, we demonstrate that low flow regimes potentiate the pro‐tumoral function of circulating tEVs by promoting their uptake and rerouting their trafficking. We propose that tEVs contribute to pre‐metastatic niche formation by exploiting endothelial mechanosensing in specific vascular regions with permissive hemodynamics.
Machine Learning and Neural Networks for Modelling the Retention of PPhACs by NF/RO
Authors: Ammi Yamina , Si-Moussa Cherif , Hanini Salah 
Published: November 2023

The retention of polar pharmaceutical active compounds (PPhACs) by nanofiltration and reverse osmosis (NF/RO) membranes is of paramount importance in membrane separation processes. The retention of 21 PPhACs was correlated using artificial intelligence techniques: multi-layer perceptron (MLP), feedforward neural network with radial basis function (RBF), and support vector machine (SVM). A database of 541 retention values has been collected from the literature. The results showed a high predictive capacity of the MLP model for the retention of PPhACs by NF/RO with a very high correlation coefficient (&lt;i&gt;R&lt;/i&gt; = 0.9714) and a very low root mean squared error (RMSE = 3.9139 %) for the entire data set. The comparison between the three models showed the superiority of the MLP model. The sensitivity analysis emphasised that the retention of PPhACs is governed by three interactions arranged in descending order: polarity interactions (hydrophobicity/hydrophilicity), electrostatic repulsion, and steric hindrance. This research suggests that the PPhACs retention on the NF/RO membrane strongly depends on the topological polar surface area.
The linguistic landscape of Lamma Island
Authors: Militello Jacqueline Marie White , Theng Andre Joseph , Kong Yik Lam Charmaine , Singh Jaspal Naveel 
Published: November 2023

Lamma Island, while only a short 30-minute ferry ride from the intensely metropolitan centre of Hong Kong Island, the ‘most vertical city’ in the world, represents a rural diametric as an ‘outlying island’: lightly populated with both a long-standing local population and a transient ‘expatriate’ population. We argue that the main village Yung Shue Wan represents a ‘border nexus’ between the urban and the rural. This becomes evident through our autoethnographic linguistic landscape (LL) approach, where the four authors use four different positionalities towards understanding how displayed discourse is oriented to multiple centres of authority – that is, the municipal, regional, communal, and touristic – creating Lamma’s unique polycentric sense of place. We show that polycentricity is not only intrinsic to signs but is also contingent on those who read them. We foreground the role of autoethnographic reflexivity in LL analysis, as collaboratively studied via video conferencing tools in light of the pandemic.
Hereditary cancer syndromes with increased risk of renal cancer
Authors: Mikhaylenko D. S. , Gorban N. A. , Zaletaev D. V. 
Published: November 2023

Renal cancer (RC) is one of the three most common diseases in oncologic urology. Its accurate diagnosis and prognosis remain difficult and important problems. Some cases of RC are associated with hereditary cancer syndromes and are caused by germline mutations. This review describes monogenic forms of hereditary RC (von Hippel–Lindau syndrome, Birt–Hogg– Dubé syndrome, hereditary leiomyomatosis and renal cell cancer, hereditary papillary renal carcinoma, BAP1 tumor predisposition syndrome) and diseases with several candidate genes (SDH-mutated tumors, tuberous sclerosis complex). Additionally, the review discusses the increased risk of RC in patients with frequent hereditary cancer syndromes predisposing to the development of a wide range of tumor types: Lynch and Li-Fraumeni syndromes. RC in combination with other carcinomas can develop in patients carrying pathogenic mutations in the candidate genes of different hereditary cancer syndromes – multi-locus inherited neoplasia allele syndrome (MINAS) – which is especially important due to the growing role of high-throughput sequencing in practical oncologic genetics. Additionally, guidelines on modern laboratory genetic diagnostics and active surveillance are presented for each syndrome.
Clinical use of high dose-rate brachytherapy in treatment of patients with localized prostate cancer and infravesical obstruction
Authors: Yagudaev D. M. , Martov A. G. , Ergakov D. V. , Yagudaev D. D. , Kadyrov Z. A. 
Published: November 2023

Background. High dose-rate brachytherapy is a new method of interstitial radiation therapy for treatment of localized prostate cancer. The difference from low dose therapy is temporary implantation of radiation sources with targeted high dose-rate irradiation of the affected organ.Aim. To evaluate 3-year effectiveness and safety of high dose-rate brachytherapy in patients with infravesical obstruction. Materials and methods. Between January of 2017 and December of 2019 at the Central Clinical Hospital “RZD-medicine”, 49 patients (mean age 67.8 ± 7.5 years) with verified prostate cancer diagnosis underwent high dose-rate brachytherapy in the regimen of 2 sessions of 15 Gy with 192Ir source. The inclusion criteria were disease stage ≤сТ2с, Gleason score ≤7. Patients were divided into 2 groups: 1st – patients with incidental prostate cancer (n = 21) who previously (more than 6 months ago, mean time 9.4 ± 2.4 months) underwent transurethral prostatectomy; 2nd – patients with verified prostate cancer (mean prostate volume 56 cm3) and obstructive symptoms without previous transurethral prostatectomy (n = 28).Results. In both groups, no intraoperative complications were observed. In 6 (28 %) patients of the 1st group and 2 patients of the 2nd group, grade II genitourinary toxicity in the form of moderate dysuria and nocturia was observed. Acute gastrointestinal toxicity was observed in 3 (14 %) patients of the 1st group, in the 2nd group such complications were absent. In the 2nd group during the postoperative period after the 2nd session, 4 patients (14 %) experienced acute urinary retention requiring cystostomy.Conclusion. High dose-rate brachytherapy is a safe and effective radical treatment method for patients with localized prostate cancer with obstructive symptoms who have contraindications for surgical treatment.
Laparoscopic extraperitoneal radical cystoprostatectomy: for whom and how?
Authors: Perlin D. V. , Aleksandrov I. V. , Shmanev A. O. , Shamhalov Sh. , Kulikov P. A. 
Published: November 2023

Background. Laparoscopic radical cystectomy is an established reliable minimally invasive method for the treatment of muscle-invasive bladder cancer. However, in the elderly and patients with serious comorbidities, laparoscopic radical cystectomy is still associated with high risk of complications. There are only a few reports on the use of extraperitoneal access for laparoscopic radical cystectomy in the literature. At the same time, extensive experience has been accumulated in laparoscopic extraperitoneal radical prostatectomy and retroperitoneoscopic operations on the kidney showing significant advantages of extraperitoneal access. Aim. To present initial results of laparoscopic radical cystectomy through extraperitoneal access in medically ill patients.Materials and methods. Between 2017 and 2021, extraperitoneal laparoscopic radical cystectomy was performed at the Volgograd Regional Uronephrology Center in four male patients with tumors affecting the bladder, stages T2–T4. All patients had serious comorbidities. In 3 patients, grade G2–G3 muscle-invasive bladder cancer was histologically verified prior to cystectomy. Two of them had invasion in the posterior urethra. One patient was diagnosed with prostate adenocarcinoma (Gleason score 8 (5 + 3)) with invasion into the bladder wall, ureterohydronephrosis and stage IV chronic kidney disease. None of the patients received neoadjuvant therapy: in 2 cases surgeries were emergency due to recurrent hemorrhages, and 3 patients had significantly decreased kidney function.Results. All operations were performed completely laparoscopically through extraperitoneal access. In 1 case, urine diversion was performed transperitoneally into a colon conduit. Simultaneous retroperitoneoscopic ureterocutaneostomy was performed in two patients: on one side (in a patient with a single functioning kidney) and on both sides, respectively. In a patient with stage V chronic kidney disease and permanent dialysis, bilateral simultaneous retroperitoneal nephrectomies were performed.In 2 patients, salvage cystectomy was done for recurrent bleeding that couldn’t be managed by conservative methods. The maximum intraoperative blood loss did not exceed 500 mL. Bowel function in all patients was recovered within 24–36 hours after the intervention.Conclusion. Laparoscopic extraperitoneal radical cystectomy is a reproducible minimally invasive surgical procedure for bladder cancer treatment that has advantages in terms of postoperative recovery in patients with severe comorbidities. The use of extraperitoneal access may be a rational alternative for salvage cystectomy in male patients. More observations are needed to determine the place of the method in the surgical treatment of muscle invasive bladder cancer.
Impact of using novel antitumor drugs in adult patients with locally advanced or metastatic urothelial carcinoma on reducing cancer mortality in Russia
Authors: Avxentyev N. A. , Alekseev B. Ya. , Andreyashkina I. I. , Makarova Yu. V. 
Published: November 2023

Background. Standard first-line therapy options for patients with locally advanced or metastatic urothelial carcinoma (UC) is platinum-based chemotherapy. Currently, patients also have access to immune checkpoint inhibitors (ICIs) such as pembrolizumab, nivolumab, and atezolizumab, along with avelumab, which, unlike other drugs in this class, can be used as maintenance therapy after first-line platinum-based chemotherapy.Aim. To evaluate the effects of using ICIs in treating adult patients with locally advanced or metastatic UC on reducing overall and one-year cancer mortality in Russia.Materials and methods. A mathematical model based on overall survival and progression-free survival data from clinical trials has been proposed. This model describes duration of therapy and treatment outcomes for cases of treatment without ICIs (routine clinical practice); with pembrolizumab, nivolumab, and atezolizumab in first and second-line therapy according to real-life clinical practice (current practice); and with avelumab as maintenance therapy after platinum-based chemotherapy (proposed practice) over a 3-year period. The model was used to estimate the number of lives saved and healthcare system costs when transitioning from historical to current practice, and from current to proposed practice over a three-year horizon, considering the number of locally advanced or metastatic UC patients who may start platinum-based therapy annually in Russia.Results. Annually, up to 4,182 patients with locally advanced or metastatic UC in Russia can start platinum-based chemotherapy. Compared to historical practice, the use of pembrolizumab, nivolumab, and atezolizumab in the first and second lines of therapy in accordance with the routine clinical practice allows to reduce mortality from malignant neoplasms by 553 cases over a 3-year horizon. Over the same period, avelumab-based treatment would additionally save 2,506 lives. Moreover, the cost of saving one life with the use of avelumab amounts to 6.0 million rubles, which is 9 % lower than the cost of saving one life with the use of other ICIs (6.6 million rubles).Conclusion. The use of avelumab as maintenance therapy after platinum-based chemotherapy in the 1st line in patients with locally advanced or metastatic UC has a significant and quantifiable impact on reducing cancer-related mortality in Russia.
AL-WASATHIYYAH UNTUK GEN-Z: PERSPEKTIF HABIB HUSEIN JA'FAR AL-HADAR
Authors: Annisa Annisa 
Published: November 2023

Abstract: The concept of al-wasathiyyah has now become the direction or school of Islamic thought for the benefit of the Islamic world at this time. This shows that Muslims should take the middle way, not to be extreme and not to be fanatic in religion. This research uses qualitative methods with library research. Data was collected using exploratory methods, interpretation, and analysis. After the data is collected, it is then analyzed using a descriptive content analysis technique. The results of the research found are Habib Husein Ja'far al Hadar's thoughts in conveying wasathiyyah is very necessary considering the many threats of radicalism, racism and fanaticism, especially the Z-gen which is easily provoked. In the social, cultural and religious context, it is important for Gen-Z to understand and respect existing diversity, uphold the values of moderation in religion, and work together in creating a harmonious and tolerant environment. From Habib Ja'far's delivery, it was very easy for various groups to accept. The media that he often uses in preaching is social media.Keywords: Al-Wasathiyyah, Habib Ja’far, Gen-Z. Abstrak: Konsep al-wasathiyyah saat ini telah menjadi arah atau aliran pemikiran Islam untuk kepentingan dunia Islam pada saat ini. Hal ini menunjukkan bahwa hendaknya umat Islam mengambil jalan tengah, tidak ekstrim dan tidak juga selayaknya bersikap fanatik dalam beragama. Penelitian ini menggunakan metode kualitatif dengan studi pustaka (library research). Data dikumpulkan menggunakan metode eksploratif, interpretasi, dan analisis. Setelah data terkumpul, lalu dilakukan analisis menggunakan teknik descriptive analysist content (analisis deskriptif konten). Hasil penelitian yang ditemukan adalah pemikiran Habib Husein Ja’far al Hadar dalam menyampaikan tentang wasathiyyah sangat diperlukan mengingat banyaknya ancaman radikalisme, rasisme dan fanatisme terkhusus gen-Z yang mudah terprovokasi. Dalam konteks sosial, budaya, dan agama, penting bagi gen-Z untuk memahami dan menghormati keragaman yang ada, menjunjung tinggi nilai-nilai moderasi dalam beragama, dan bekerja sama dalam menciptakan lingkungan yang harmonis dan toleran. Dari penyampaian Habib Ja’far sangat mudah di terima berbagai kalangan. Adapun media yang sering ia gunakan dalam berdakwah adalah media sosial.Kata Kunci: Al-Wasathiyyah, Habib Ja’far, Gen-Z.
A COMPARATIVE OBSERVATIONAL STUDY ON EFFECTIVENESS OF PROBIOTICS AND ANTIBIOTICS IN BACTERIAL VAGINOSIS
Authors: B Sowmya , Kar Dattatreya , Panigrahy Rajashree , Pati Basanta 
Published: November 2023

Introduction: Bacterial vaginosis is a common vaginal dysbiosis in women of reproductive age. Bacterial vaginosis is a dysbiosis characterized by a reduction of Lactobacillus species, such as L. crispatus, L. gasseri, and L. Jensenii. Anti-microbial resistance of BV pathogens and low long-term cure rates have been increasing in the few years. Aim: Probiotics are proposed as an alternative treatment for BV applying live micro-organisms with the capacity to confer health benefits to the patient. Methods: Patients with white discharge per vagina with or without foul smell, and itching visiting Obstetrics and Gynecology OPD are subjected to Amsel criteria. Those test positive for 3 out of 4 are diagnosed to have bacterial vaginosis and were enrolled in the study. Result: Highest prevalence of bacterial vaginosis was at the age group of 26-30 years (28%), with the lowest prevalence (16%) above 40 years of age. Among group A (probiotics), 68% and 32% of women were in not working and working groups, respectively, when compared with group B (antibiotics), 64% and 36% of women were in not working and working groups. Nulligravida (28% and 32%), Singleton Pregnancy (32% and 16%) in Group A and Group B. We observed that patients treated with both antibiotics (50%) and probiotics (50%) had similar recurrence rates of BV. Conclusion: Hence it would be prudent to prefer probiotics in patients with BV, as they colonize other normal commensals and have similar efficacy as that of antibiotics. The other beneficial factors of probiotics include acceptability to patients and nil side effect profile.
Bilateral Posterior Bone Graft Augmentation for Severe Glenoid Hypoplasia Without Instability
Authors: Levins James G. , Hoffman Ryan A. , Green Andrew 
Published: November 2023

Case:
A 40-year-old man with shoulder pain secondary to severe bilateral glenoid hypoplasia without posterior instability was treated successfully with bilateral posterior glenoid bone graft augmentation.

Conclusion:
While glenoid hypoplasia is associated with a variety of patient presentations, treatment of the stable and nonarthritic shoulder is rarely described. A posterior glenoid bone graft can be used to augment deficient posterior glenoids, increasing the articulating surface area, restoring function, and potentially facilitating future shoulder arthroplasty.
Clinical Diagnosis of Common Overlapping Shoulder and Cervical Spine Disorders
Authors: Sakthivelnathan Vishaal , Somerson Jeremy S. , Alijanipour Pouya 
Published: November 2023

» Pain in the shoulder is a common orthopaedic complaint that can be caused by shoulder or neck pathologies.» Shoulder and neck pathologies often coexist, among which one may be a predisposing factor for the other.» History, physical examination, and diagnostic injections can be used to discern the cause of shoulder pain and guide treatment.
How can governments engage in adaptation tracking? A protocol for assessing national adaptation policies
Authors: Nowak Andreea C. , Njuguna Lucy , Crumpler Krystal 
Published: November 2023

Abstract
A myriad of frameworks to track adaptation to climate change have been developed in recent years. They have been instrumental in advancing the conversation on assessing adaptation progress and effectiveness across national and global scales. Surprisingly, very little attention is given to how countries can leverage existing policies to engage in adaptation tracking. We developed a Protocol to assess the ability of national policies to deliver comprehensive, coherent, and robust information on adaptation, which would allow governments to leverage existing efforts for engaging in country-driven tracking processes. The Protocol establishes data collection and analytical steps, including document screening, data extraction, quality assurance, and coding rules to ensure consistent interpretation and comparability of results. We applied the Protocol in an assessment of Nationally Determined Contributions (NDCs) and National Adaptation Plans (NAPs) of African countries. The resulting dataset represents the most comprehensive overview available to date on existing entry points for adaptation tracking for Africa. While this can help show progress in adaptation planning, the real challenge lies in generating evidence of adaptation effectiveness. This requires complementary assessments of how intentions and plans translate into actions or results on the ground, aspects which our Protocol does not cover.
Enhancing eco-environmental sustainability and wheat security in China: a sequential knowledge-based nitrogen strategy aligned with regional targets
Authors: Cao Qiang , Li Yue , Liu Xueqin , Tian Xu , Ladha Jagdish , Cammarano Davide , Ata-UI-Karim Syed , Liu Xiaojun , Tian Yongchao , Zhu Yan , Cao Weixing 
Published: November 2023

Abstract
The dual implications of nitrogen (N) use raise concerns regarding future wheat production, economic profitability, and environmental protection in China. Here, a comprehensive and sequential knowledge-based strategy that combines regional target-oriented optimal N rates and management practices was devised; as well as exploring its perspectives for promoting agricultural sustainability. It was found that employing a multi-objective optimization strategy that coordinates various government departments can lead to a reduction of 18.7–21.9% in N fertilizer consumption and 25.4–30.5% in reactive N losses while maintaining wheat yields compared to conventional N management. Furthermore, a combination of N rate optimization and management practices based on the principles of right time, rate, placement, and product could save economic costs of about 0.18–1.65 billion US dollars. The new strategy offers an example of how high economic and environmental benefits can be achieved with regional N optimization management while ensuring food security to guide targeted agricultural interventions.