bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcutaneous spinal cord stimulation combined with robotic-assisted body weight-supported treadmill training enhances motor score and gait recovery in incomplete spinal cord injury: a double-blind randomized controlled clinical trial
Authors: Comino-Suárez Natalia , Moreno Juan C. , Megía-García Álvaro , del-Ama Antonio J. , Serrano-Muñoz Diego , Avendaño-Coy Juan , Gil-Agudo Ángel , Alcobendas-Maestro Mónica , López-López Esther , Gómez-Soriano Julio 
Published: January 2025

Abstract

Background
Although transcutaneous spinal cord stimulation (tSCS) has been suggested as a safe and feasible intervention for gait rehabilitation, no studies have determined its effectiveness compared to sham stimulation.

Objective
To determine the effectiveness of tSCS combined with robotic-assisted gait training (RAGT) on lower limb muscle strength and walking function in incomplete spinal cord injury (iSCI) participants.

Methods
A randomized, double-blind, sham-controlled clinical trial was conducted. Twenty-seven subacute iSCI participants were randomly allocated to tSCS or sham-tSCS group. All subjects conducted a standard Lokomat walking training program of 40 sessions (5 familiarization sessions, followed by 20 sessions combined with active or sham tSCS, and finally the last 15 sessions with standard Lokomat). Primary outcomes were the lower extremity motor score (LEMS) and dynamometry. Secondary outcomes included the 10-Meter Walk Test (10MWT), the Timed Up and Go test (TUG), the 6-Minute Walk test (6MWT), the Spinal Cord Independence Measure III (SCIM III) and the Walking Index for Spinal Cord Injury II (WISCI-II). Motor evoked potential (MEP) induced by transcranial magnetic stimulation (TMS) were also assessed for lower limb muscles. Assessments were performed before and after tSCS intervention and after 3-weeks follow-up.

Results
Although no significant differences between groups were detected after the intervention, the tSCS group showed greater effects than the sham-tSCS group for LEMS (3.4 points; p = 0.033), 10MWT (37.5 s; p = 0.030), TUG (47.7 s; p = 0.009), and WISCI-II (3.4 points; p = 0.023) at the 1-month follow-up compared to baseline. Furthermore, the percentage of subjects who were able to walk 10 m at the follow-up was greater in the tSCS group (85.7%) compared to the sham group (43.1%; p = 0.029). Finally, a significant difference (p = 0.049) was observed in the comparison of the effects in the amplitude of the rectus femoris MEPs of tSCS group (− 0.97 mV) and the sham group (− 3.39 mV) at follow-up.

Conclusions
The outcomes of this study suggest that the combination of standard Lokomat training with tSCS for 20 sessions was effective for LEMS and gait recovery in subacute iSCI participants after 1 month of follow-up.

Trial registration ClinicalTrials.gov (NCT05210166).
Targeting RNA splicing modulation: new perspectives for anticancer strategy?
Authors: Lv Xuemei , Sun Xiaoyu , Gao Yang , Song Xinyue , Hu Xiaoyun , Gong Lang , Han Li , He Miao , Wei Minjie 
Published: January 2025

Abstract
The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tumors. Therefore, identifying cancer-specific subtypes from aberrant processing offers new opportunities for therapeutic development. Numerous splicing modulators, each utilizing different mechanisms, have been developed as promising anticancer therapies, some of which are in clinical trials. In this review, we summarize the splice-altered signatures of cancer cell transcriptomes and the contributions of splicing aberrations to tumorigenesis and progression. Especially, we discuss current and emerging RNA splicing-targeted strategies for cancer therapy, including pharmacological approaches and splice-switching antisense oligonucleotides (ASOs). Finally, we address the challenges and opportunities in translating these findings into clinical practice.
Changing dynamics of bloodstream infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium in Germany, 2017–2023: a continued burden of disease approach
Authors: Brinkwirth Simon , Feig Marcel , Noll Ines , Eckmanns Tim , Dörre Achim , Haller Sebastian , Willrich Niklas 
Published: January 2025

Abstract

Background
Antimicrobial resistance is a global threat to public health, with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREfm) being major contributors. Despite their clinical impact, comprehensive assessments of changes of the burden of bloodstream infections in terms of Disability-Adjusted Life Years (DALYs) and attributable deaths over time are lacking, particularly in Germany.

Methods
We used data from the Antimicrobial Resistance Surveillance system, which covered about 30% of German hospitals. Bloodstream infections were defined by a VREfm or MRSA-positive blood culture. We estimated incidences as a first step to further use these rates to calculate DALYs and attributable deaths using the Burden of Communicable Disease in Europe toolkit. The analysis included stratification by age, sex and region.

Results
From 2017 to 2023, 6262 MRSA and 5442 VREfm blood culture-positive isolates were identified. The incidence of MRSA bloodstream infections decreased from 4.0 to 2.1 per 100,000 population, with estimated DALYs decreasing from 14.6 to 8.6 per 100,000 and attributable deaths from 591 to 316. Conversely, VREfm-BSI incidence doubled from 1.7 to a peak of 3.0 (2021) before declining back to 1.7 per 100,000 in 2023, with estimated DALYs increasing from 8.9 to 16.5 and then decreasing to 8.5 per 100,000 and attributable deaths increasing from 317 to 327. Men and people over 60 years had the highest burden, with noticeable regional differences.

Conclusion
MRSA and VREfm bloodstream infections followed different trends in the past and now present a comparable burden in Germany. Both pathogens pose a significant threat, particularly to hospitalised older aged men. Our findings highlight the need for targeted prevention and continued surveillance of MRSA and VREfm to reduce infections and their impact.
Impact of advanced lung cancer inflammation index on all-cause mortality among patients with heart failure: a systematic review and meta-analysis with reconstructed time-to-event data
Authors: Amin Ahmed Mazen , Ghaly Ramy , Elbenawi Hossam , Ewis Abdelrahman , Khan Ubaid , Elshaer Khaled S. M. , Abuelazm Mohamed , Abdelazeem Basel , Patel Brijesh , Timimi Farris K. , Elgendy Islam Y. 
Published: January 2025

Abstract

Background
Heart failure (HF) is associated with systemic inflammation and hypercatabolic syndrome, impacting body metabolism. The advanced lung cancer inflammation index (ALI) is a novel inflammatory and nutritional biomarker. We aimed to investigate the prognostic role of ALI in patients with HF.

Methods
We comprehensively searched PubMed, WOS, SCOPUS, EMBASE, and CENTRAL through October 2024. We conducted a pair-wise and prognostic systematic review and meta-analysis with a reconstructed time-to-event data meta-analysis. All analyses were performed using R V. 4.3.1. This meta-analysis was registered at PROSPERO (CRD42024535227).

Results
We included five studies with 2,795 patients. In the pair-wise meta-analysis, ALI ≤ 25 was significantly associated with an increased incidence of all-cause mortality compared with ALI > 25 (risk ratio [RR] 1.73, 95% confidence interval [CI] 1.36–2.21, P < 0.01). On the adjusted prognostic meta-analysis, higher ALI was significantly associated with a reduction in the risk of all-cause mortality (hazards ratio [HR] 0.45, 95% CI 0.35–0.58-, P < 0.01). The reconstructed Kaplan Meier showed that ALI > 25 was significantly associated with a 56% reduction in the risk of all-cause mortality compared with ALI ≤ 25 (HR 0.44, 95% CI 0.38–0.50, P < 0.000001).

Conclusion
Among patients with HF, a low ALI was associated with a higher incidence of all-cause mortality rate than those with a high ALI. These findings suggest that ALI can be used for prognostic stratification and aid clinical decision-making in HF management.
Anemia during pregnancy and adverse maternal outcomes in Georgia–A birth registry-based cohort study
Authors: Skhvitaridze Natia , Gamkrelidze Amiran , Manjavidze Tinatin , Brenn Tormod , Anda Erik Eik , Rylander Charlotta 
Published: January 2025

Background
Anemia in pregnancy is an important public health challenge; however, it has not been thoroughly studied in Georgia. We assessed the prevalence of anemia during pregnancy across Georgia and the association between anemia in the third trimester of pregnancy and adverse maternal outcomes.

Methods
We used data from the Georgian Birth Registry and included pregnant women who delivered between January 1, 2019, and August 31, 2022 (n = 158,668). The prevalence of anemia (hemoglobin (Hb) < 110 g/L) at any time during pregnancy was calculated per region. Pregnant women were classified into anemia severity groups based on their lowest measured Hb values, taking into account the thresholds for each trimester of pregnancy as defined by the WHO recommendations for anemia classification. Adjusted odds ratios (aOR) with 95% confidence intervals (CIs) were calculated for the associations between anemia status and post-delivery intensive care unit (ICU) admission and preterm delivery.

Results
The prevalence of anemia occurring at least once during pregnancy was 33.1%, with large regional differences in anemia prevalence (19.2%–32.8%). Of 105,811 pregnant women with Hb measurements in the third trimester, 71.0% had no anemia; 20.9%, mild anemia; and 8.1%, moderate or severe anemia. The odds of post-delivery ICU admission did not increase linearly with decreasing Hb value (P for trend .13), and the relationship was inverse for preterm delivery (P for trend .01).

Conclusions
A considerable proportion of pregnant women in Georgia have anemia during pregnancy, and the prevalence and quality of reporting differ across regions. Anemia occurring in the third trimester did not substantially increase the odds of maternal ICU admission or preterm delivery. To progress toward sustainable development goals and alleviate the public health burden of anemia, it is essential to not only identify and manage anemia during pregnancy but also address underlying factors with a multifaceted response.
Genetic influence on choroidal vascularity index
Authors: Yoon Je Moon , Gil Yong Jin , Sung Joohon , Ham Don-Il , Kong Mingui 
Published: January 2025

Purpose
To investigate the heritability of genetic influence on macular choroidal vascularity index (CVI).

Methods
Total choroidal area (TCA), luminal area (LA), and CVI was measured using horizontal scan of spectral-domain optical coherence tomography with enhanced depth imaging in the 373 healthy twin participants. Characteristics of the participants were investigated, including age, sex, axial length, hypertension, diabetes, drinking habits, and smoking status. Univariate and subsequent multivariate regression analyses were performed to evaluate the associations of these factors with TCA, LA, and CVI.

Results
Patients who were older and had a higher intraocular pressure, higher diastolic blood pressure, and lower pulse pressure showed associations with lower CVI (p<0.001, p = 0.014, p = 0.005, and p = 0.015, respectively). The covariate-adjusted heritability (±standard error) of the CVI was 0.716 ± 0.091, and the heritabilities of the TCA and LA were 0.691 ± 0.089 and 0.634 ± 0.100, respectively.

Conclusion
The TCA, LA, and CVI are highly heritable.
Mit Künstlicher Intelligenz zu besserer Nutzbarkeit: Die „Zentralen Serien des Kantons Zürich (19. und 20. Jahrhundert)“ neu zugänglich gemacht
Authors: Arnecke Patrick , Plüss Rebekka 
Published: January 2025

Zusammenfassung
Der Beitrag zeigt auf, wie das Staatsarchiv und Statistische Amt des Kantons Zürich in einer gemeinsamen Initiative eine KI-gestützte Suchlösung für die „Zentralen Serien des Kantons Zürich (19. und 20. Jahrhundert)“ (ZSZH) entwickelt haben.
Persuasion Strategies in Facebook Health Communication: A Comparative Study between Egypt and the United Kingdom
Authors: El-Dakhs Dina Abdel Salam , Ahmed Mervat M. 
Published: January 2025

Abstract
The current study aims to examine the persuasive strategies used in Facebook posts by the Egyptian Ministry of Health and Population and the British Department of Health and Social Care. A total of 400 Facebook posts, 200 by each department of health, were analyzed for persuasion strategies using a recent persuasion model by Dontcheva-Navratilova et al. (2020). The findings showed that both departments primarily relied on ethos-based strategies, followed by logo-based strategies, while their use of pathos-based strategies was minimal. The findings also showed that the Egyptian posts included more direct appeals to the audience, logical reasoning, and emphasis on care and responsibility than the British posts. In contrast, the British posts employed the strategies of reference to expert opinion, creating a sense of community, reference to facts and statistics, and provision of exemplification and evidence significantly more frequently than the Egyptian posts. The results are interpreted in terms of the existing literature and relevant cultural models.
Execution of Judgments of the European Court of Human Rights: Actors, Substance and Procedure
Authors: Janczarek Szymon , Kolomiets Nikita 
Published: January 2025

Abstract
The system established by the European Convention on Human Rights, including execution of judgments of the European Court of Human Rights, has made an extraordinary contribution to the protection and promotion of human rights in Europe. Thus, while the Committee of Ministers of the Council of Europe continues to supervise the execution of thousands of judgments of the European Court, it has at the same time closed its supervision in respect of even more cases because thousands of the human rights problems previously raised under the Convention are now considered to have been resolved. While suggesting that the system of execution of judgments of the European Court works effectively, this paper would allow the reader to assess its effectiveness by looking at the execution statistics through the prism of the presented knowledge of the actors of the execution process, its content and the procedure of supervision by the Committee of Ministers.
Sliding mode sensorless control model of hub motor based on digital twin technology
Authors: Hong Bin , Li Fugeng , Feng Changyuan , Hou Jing , Nie Yahui , Cao Zhan , Ma Zhihao 
Published: January 2025

Abstract
This paper introduces a novel integration of sliding mode control and digital twin technology to develop a sensorless control model for hub motors. The proposed approach overcomes the limitations of traditional methods, such as the inability to pre-evaluate parameter changes and the lack of multidimensional monitoring and interaction analysis. The constructed model enables real-time simulation that closely reflects actual motor behavior, allowing precise tuning and validation of control parameters. Simulation results show that the system achieves rapid response, robust performance under varying load and speed conditions, and superior adaptability compared to existing methods. These advancements highlight the potential of this approach for precise and robust motor control in robotics and autonomous vehicles.
The Influence of Transformational Leadership and Compensation on Employee Performance through Work Motivation
Authors: Silvia Hendrayanti  , Sari Cahyani Tunggal 
Published: January 2025

Primadana Yogyakarta Savings and Loans Cooperative has problems with leadership style and compensation which ultimately affects employee performance. It was found that leaders were less familiar with subordinates, leaders were more focused on building relationships with superiors and less focused on subordinates, and employees felt the percentage value of each compensation was getting smaller. The problems that occur require further research to be carried out. The purpose of this research is to determine the direct and indirect influence of Transformational leadership and compensation on employee performance through work motivation at the Yogyakarta Primadana Savings and Loans Cooperative. The population in this study were 62 employees of the Yogyakarta Primadana Savings and Loans Cooperative. The data collection method uses a questionnaire with the data analysis method using the path analysis test with the SPSS application. This research shows that transformational leadership has a positive and significant effect on employee motivation and performance, compensation has a positive and significant effect on employee motivation and performance. Motivation mediates the influence of transformational leadership and compensation on employee performance at the Yogyakarta Primadana Savings and Loans Cooperative. Companies must, through managers/leaders, strive to continue implementing a transformational leadership style and develop work motivation and empowerment for employees, because this has an influence on the performance that will be achieved by company employee.
КРУГЛЫЙ СТОЛ «ОПЫТ ИНДУСТРИАЛИЗАЦИИ В СССР: ЗАМЫСЛЫ, ОСОБЕННОСТИ ПРОВЕДЕНИЯ, ИТОГИ»
Authors: РЫНКОВ В.М. , АРСЕНТЬЕВ Н.М. , КРАСИЛЬНИКОВ С.А. , КЛИСТОРИН В.И. , БОРОДКИН Л.И. , ПЕТРОВ Ю.А. , ГОЛИЦЫН Ю.П. , ПОБЕРЕЖНИКОВ И.В. , АРТЕМОВ Е.Т. , ЛИЗУНОВ П.В. , ИСАЕВ В.И. 
Published: January 2025

В июне 2024 г. в Институте истории СО РАН состоялась Всероссийская научная конференция «Индустриальное развитие России»: этапы, особенности, перспективы изучения», посвященная 95-летию индустриализации с СССР. На конференции обсуждались вопросы разработки и реализации направлений индустриального развития России в широком хронологическом и проблемном контекстах с акцентом на советскую индустриализацию первых пятилеток. Она завершилась работой круглого стола, участники которого обсудили перспективы развития исследований феномена советской индустриализации, обосновали необходимость сравнения двух типов индустриализации - «виттевской» и советской, а также дальнейшего изучения источников, внутреннего и внешнеполитического контекстов советской индустриализации, роли внешнеполитического фактора в реализации ее сценария.
In June 2024, the All-Russian Scientific Conference “Industrial Development of Russia: Stages, Features, Study Prospects” was held in Novosibirsk, dedicated to the 95th anniversary of industrialization in the USSR. The conference discussed the development and implementation of areas of industrial development in Russia in a broad chronological and problematic context with an emphasis on the Soviet industrialization of the first five-year plans. It ended with a Round Table meeting “Experience of Industrialization in the USSR: Plans, Features of Implementation, and Results”. It discussed the prospects for developing research into the phenomenon of Soviet industrialization. The participants emphasized the need to compare two types of industrialization - the “Witte’s” and the Soviet, as well as to continue studying the sources, inner and outer contexts of Soviet industrialization, special role of foreign policy factor in implementation of its scenario. The edited transcript of the Round Table is published below.
ОЦИФРОВКА КНИЖНОГО НАСЛЕДИЯ: НОВЫЕ ВОЗМОЖНОСТИ ДЛЯ ИЗУЧЕНИЯ ИСТОРИИ ЧТЕНИЯ XVIII В
Authors: МОРЕВА О.В. 
Published: January 2025

Изучение истории чтения - важная исследовательская задача, решение которой часто усложняется из-за труднодоступности источников. Издания, выпущенные до 1830 г. включительно, согласно ФЗ-78 «О библиотечном деле», являются «книжными памятниками». Это означает, что для фондодержателей сохранность имеет приоритет над доступностью. Оцифровка культурного наследия, начавшаяся в 2018 г., сделала доступными цифровые копии книжных памятников в высоком разрешении. Целью статьи является изучение новых возможностей, которые открывает оцифровка для исследователей истории чтения и читательских практик. Для более глубокого исследования нами избран один из журналов, издававшихся в 1779-1781 гг. в типографии Академии наук - «Академические известия». Книги и журналы представляют собой комплексный исторический источник, согласно классификации И.Д. Ковальченко, они относятся к письменному и вещественному типу, ценность их возрастает, если на них сохранились следы бытования. Доступность полного комплекта раритетного литературно-научного журнала XVIII в. позволяет выполнить тематический анализ содержания, а сохранившиеся записи Н.А. Демидова (1656-1725) по поводу прочитанного - реконструировать его читательские практики и круг чтения.
The study of the history of reading is an important research task, the solution of which is often complicated due to the inaccessibility of sources. Publications issued before 1830 inclusive, according to Federal Law No. 78 “On Librarianship”, are “book monuments”. This means that for fond holders, safety takes precedence over accessibility. The digitization of cultural heritage, which began in 2018, has made digital copies of book monuments available in high resolution. The purpose of the article is to explore the new opportunities that digitization opens up for researchers of the history of reading and reading practices. For a deeper study, we have chosen one of the journals published in 1779-1781 in the printing house of the Academy of Sciences - “Academic News”. Books and magazines are a complex historical source, according to I.D. Kovalchenko’s classification, they belong to the written and material type, their value increases if traces of existence are preserved on them. The availability of a complete set of a rare literary and scientific journal of the XVIII century allows you to perform a thematic analysis of the content, and the preserved records of N.A. Demidov (1656-1725) about what he read - to reconstruct his reading practices and reading circle.
300 ЛЕТ СЛУЖЕНИЯ ОТЕЧЕСТВУ РЕЦЕНЗИЯ НА ИЗДАНИЕ: «РОССИЙСКАЯ АКАДЕМИЯ НАУК: 300 ЛЕТ ИСТОРИИ: В 2-Х ТОМАХ». М.: НАУКА, 2024
Authors: КУПЕРШТОХ Н.А. 
Published: January 2025

Фундаментальное двухтомное издание по истории Российской академии наук подготовлено коллективом авторов к 300-летию Российской академии наук (РАН). Уникальность двухтомника заключается в том, что он является первым опытом создания истории Академии наук с широким привлечением документальных материалов из Архива РАН и его филиала в Санкт-Петербурге. Главная идея издания - совместить изложение истории РАН как научного учреждения с обзором результатов ее научной деятельности в различные периоды, а также представить современникам исторические портреты выдающихся членов Академии наук за 300 лет ее деятельности.
The present paper is a review of the fundamental two-volume publication on the history of the Russian Academy of Sciences, prepared by a team of authors for the 300th anniversary of the RAS. The uniqueness of the two-volume book is in the fact that it is the first attempt to compose the history of the Academy of Sciences with the extensive use of documentary materials from the Archive of the Russian Academy of Sciences and its branch in St. Petersburg. The main idea of the publication is to combine a presentation of the history of the RAS as a scientific institution with a review of the results of its scientific activities in various periods, as well as to present historical portraits of outstanding members of the Academy over the entire period of its activity to contemporaries.