bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of Orelabrutinib-based regimens in diffuse large B-cell lymphoma: a single-center retrospective analysis
Authors: Wei Ruowen , Wu Yingying , Jiang Shan , Zhang Ao , Zhang Lu , Liu Ling , Wang Yadan , Zhang Min , Mei Heng , Liu Fang , Xia Linghui , Cui Guohui , Fang Jun 
Published: November 2023

AbstractCurrently, combining chemotherapy with Bruton tyrosine kinase inhibitors (BTKi) has demonstrated significant effectiveness in treating patients with diffuse large B-cell lymphoma. Orelabrutinib is a second-generation BTK inhibitor, and presently, there have been few reports of Orelabrutinib being used to treat DLBCL. We conducted a retrospective investigation to explore the safety and efficacy of Orelabrutinib in combination with chemotherapy or immunotherapy. The study comprised 19 patients with a median age of 61 years. The overall response rate (ORR) was 89.5% with a complete response (CR) rate of 73.7% and a partial response rate (PR) of 15.8%. The estimated 2-year overall survival (OS) and progression-free survival (PFS) rates were 78.6% (95%CI, 59.8%–100%) and 72.2% (95% CI, 52.4%–99.6%), respectively, with a median follow-up time of 11 months (range 2–24). The most prevalent grade 3 or 4 adverse events (AEs), neutropenia (52.6%), anemia (36.8%), thrombocytopenia (26.3%), febrile neutropenia (26.3%), and lung infection (10.5%), were the most common. Our results reveal that Orelabrutinib is an effective therapy for DLBCL patients. Furthermore, our first investigation of the Orelabrutinib application lays a foundation for larger retrospective studies.
Reducing the carbon footprint of buildings using biochar-based bricks and insulating materials: a review
Authors: Osman Ahmed I. , Farghali Mohamed , Dong Yitong , Kong Jiashu , Yousry Mahmoud , Rashwan Ahmed K. , Chen Zhonghao , Al-Fatesh Ahmed , Rooney David W. , Yap Pow-Seng 
Published: November 2023

AbstractThe rapid growth of global industrialization and urbanization has led to the excessive use of non-renewable energy sources and the alarming release of greenhouse gases within the construction industry. In response, adopting sustainable and environmentally friendly building materials has emerged as a vital solution for achieving the international sustainable development goals set by the United Nations. This review discusses the potential benefits of incorporating biochar-based bricks and insulation materials, focusing on their preparation methods, material properties, emission reduction capabilities, effectiveness in reducing carbon emissions, enhancing thermal insulation, and promising economic prospects. The major points are: (1) Biochar-based materials offer significant potential for reducing the carbon footprint of buildings and enhancing their thermal insulation properties. (2) With a thermal conductivity ranging from 0.08 to 0.2 W/(m·K), biochar insulation materials contribute to reduced energy consumption and greenhouse gas emissions. (3) Replacing one ton of cement with biochar in brick production can substantially reduce 1351–1505 kg CO2-eq over the entire life cycle. (4) Using biochar as part of concrete insulation saves about 59–65 kg of carbon dioxide per ton while offering clear economic benefits. Although biochar insulation is comparatively more expensive than traditional insulation materials like fiberglass and foam, its energy-saving advantages can balance the extra cost. (5) Biochar insulation is derived from organic waste, contributing to improved recyclability, environmental sustainability, and cost-effectiveness.
Country-wide assessment of biodiversity, naturalness and old-growth status using national forest inventory data
Authors: Borghi Costanza , Francini Saverio , McRoberts Ronald E. , Parisi Francesco , Lombardi Fabio , Nocentini Susanna , Maltoni Alberto , Travaglini Davide , Chirici Gherardo 
Published: November 2023

AbstractAssessing forest biodiversity, naturalness and old-growth status (B-N-OG) is crucial for supporting sustainable forest planning, yet comprehensive monitoring networks specifically designed for such purposes are lacking in many countries. National Forest Inventories (NFIs) are the official source of statistics on status and trends of forests. While initially designed for wood production assessment, NFI data may be pivotal for ecological forest monitoring, thanks to their robust sampling protocols—enabling statistical inference—and regular field campaigns that ensure continuous information updates. As a consequence, in this study we explore the potential of NFIs for estimating B-N-OG indexes, aiming to establish compatible, scientifically relevant, and cost-effective indicators using existing NFI data at a European level. Based on data from the 2005 Italian NFI collected from 6563 plots, 18 indicators were selected following previous experiences and then used to estimate B-N-OG aggregated indexes. Relationships between the 18 indicators and the three indexes were investigated, along with comparisons of their relationships relative to forest type categories, management types and protected versus non-protected areas. Results confirm that NFI data offer valuable insights into specific B-N-OG indexes, especially concerning forest structure and deadwood. Moreover, the indexes contribute to developing meaningful relationships across geographic regions, forest categories and types of management. However, limitations in NFI field protocols are evident, as they are not explicitly designed for certain indicators. The study suggests the potential for NFIs to evolve into accessible, harmonized European reference networks for B-N-OG assessment for better supporting sustainable forest management, planning and conservation decisions related to forest ecosystems.
Use of contrast-enhanced harmonic endoscopic ultrasonography for the diagnosis of pancreatic cystic lesions
Authors: Ohno Eizaburo , Kuzuya Teiji , Kawabe Naoto , Nakaoka Kazunori , Tanaka Hiroyuki , Nakano Takuji , Miyachi Yohei , Hashimoto Senju , Hirooka Yoshiki 
Published: November 2023

AbstractEndoscopic ultrasonography (EUS) provides high spatial and contrast resolution and is a useful tool for evaluating the pancreato-biliary regions. Recently, contrast-enhanced harmonic EUS (CH-EUS) has been used to evaluate lesion vascularity, especially for the diagnosis of pancreatic tumors. CH-EUS adds two major advantages when diagnosing pancreatic cystic lesions (PCL). First, it can differentiate between mural nodules and mucous clots, thereby improving the accurate classification of PCL. Second, it helps with evaluation of the malignant potential of PCL, especially of intraductal papillary mucinous neoplasms by revealing the vascularity in the mural nodules and solid components. This review discusses the use and limitations of CH-EUS for the diagnosis of PCL.
Comparative study reveals management of a dominant invasive plant facilitates subtropical forest regeneration
Authors: Dann Leah E. , Guja Lydia , Kark Salit , Dwyer John 
Published: November 2023

AbstractInvasive plant species can drive ecosystem change, particularly on oceanic islands that are vulnerable to plant invasions and subsequent biodiversity loss. While invasive species management is vital for habitat restoration, efficacy of management efforts and the ability of native plants to regenerate varies among studies. The aim of this study was to examine the consequences of managing a thicket-forming woody plant species—Psidium cattleyanum Sabine (strawberry guava)—on subtropical forest regeneration, comparing spatial scales and management periods. We surveyed 15 locations on Norfolk Island, an isolated Pacific Island with a high proportion of endemic and threatened species, by establishing paired managed and unmanaged plots to assess changes in species-area relationships, abundance, richness, and composition of the plant community. Total plant richness was higher in managed plots at the largest scale examined (125 m2). However, there was no significant difference between managed and unmanaged plots in the slopes of species-area relationships when canopy, understory, and seedling strata were combined. Stratum-specific analyses revealed that management-driven changes were most evident in the subcanopy strata, which had significantly higher woody plant abundance and richness in managed plots. Compositional dissimilarity between managed and unmanaged plots was greater in locations with higher moisture levels, suggesting that post-management regeneration is related to environmental conditions. This study suggests that P. cattleyanum suppresses plant recruitment and its removal allows for forest regeneration, indicating that management of dominant invasive woody species facilitates plant recruitment on Norfolk Island if nearby native propagule sources are present.
Effects of protected areas on soil nematode communities in forests of the North of Portugal
Authors: Duarte A. Carolina , Guerra Carlos A. , Cano-Díaz Concha , Zeiss Romy , Carvalho-Santos Cláudia , Carvalho Rui P. , Costa Sofia R. 
Published: November 2023

AbstractNature conservation policy is mainly concerned with aboveground terrestrial species and soil biodiversity has been largely ignored, resulting in a lack of information about the conservation status of most soil organisms and about the effects that nature conservation policies have on soil systems. Forests in Northern Portugal are characterized by a remarkable diversity of ecosystems and provide habitat for an enormous diversity of living organisms. This study aims to investigate whether and to what extent protected areas and forest typology (native vs. exotic) affect soil nematode biodiversity and functions in forest ecosystems. We studied soil nematode communities, which have been widely used for their bioindicator value, to: (i) assess differences in soil biodiversity and functions between protected and non-protected areas, and between native and exotic forest types; and (ii) infer how protected areas deal with pressures and drivers of soil biodiversity and functions. We showed that current work done by nature conservation in Northern Portugal is producing some significant effects on the soil system, showing a larger Structure and Omnivore footprints and greater abundance of fungivorous and omnivorous nematodes in protected areas. Furthermore, native forest areas are better suited to ensure soil biodiversity and ecological functioning and should have a greater importance in nature conservation measures. Soil organic carbon, apparent density, soil moisture, and deciduous forest cover mainly influenced soil functional biodiversity with higher nematode trophic groups being positively associated with soil organic carbon and moisture and negatively associated with apparent density. Finally, conservation efforts targeted at the protection of native forests need to better consider effects on soil biodiversity and function, to provide an integrated protection of both aboveground and belowground components.
Significant decline in habitat specialists in semi-dry grasslands over four decades
Authors: Klinkovská Klára , Sperandii Marta Gaia , Trávníček Bohumil , Chytrý Milan 
Published: November 2023

AbstractSemi-dry grasslands are among the most species-rich plant communities in the world, harbouring many specialised and threatened species. Most of these grasslands were traditionally maintained by grazing and hay-making. After traditional management ended, protected areas were established and conservation management was introduced to protect the most valuable grassland sites. However, recent changes in land use, eutrophication and climate warming are negatively impacting the biodiversity of these grasslands. In 2022, we resurveyed historical vegetation plots in the Central Moravian Carpathians (Czech Republic), first sampled in the 1980s, to test whether the plant species composition and richness of semi-dry grasslands are changing over time and, if so, whether the decline in habitat quality and plant diversity is absent or less severe in protected areas. We found significant changes in species composition. Species richness and the proportion of habitat specialists and Red-List species decreased, whereas competitively stronger species with higher moisture and nutrient requirements increased. These trends were more pronounced outside the protected areas but also occurred within protected areas. The main factor behind these changes appears to be the cessation of traditional management and natural succession supported by eutrophication.
Development of cellulose films by means of the Ioncell® technology, as an alternative to commercial films
Authors: González Carmona Eva , Schlapp-Hackl Inge , Jääskeläinen Seppo , Järvinen Masi , Nieminen Kaarlo , Sawada Daisuke , Hummel Michael , Sixta Herbert 
Published: November 2023

AbstractIn recent years, the search for alternatives to petroleum derived products, such as plastic films, has become a priority due to the growing depletion of fossil reserves and the pollution of water resources by microplastics, microscopically small plastic particles which are harmful to ocean and aquatic life. Cellulose-based films, e.g., cellophane and cuprophane, have been on the market for almost a century. Despite being a more ecological option compared to plastic films, the manufacture of these cellulose films involves high production costs and the use of harmful chemicals. As an alternative, a sustainable and eco-friendly process based on the Lyocell-type Ioncell® technology is presented to produce cellulose films. Regenerated cellulose films are created by continuous extrusion via dry-jet wet spinning of an ionic liquid–cellulose solutions. The influence of the polymer concentration (8–13 wt%) and processing temperature (50–100 °C) on the properties of the films were studied by the determination of the thickness, mechanical properties, physical appearance, morphology, chemical composition, and hydrophobicity. The obtained films are thin (12–21 μm), transparent (transmittance = 91%) and of homogeneous structure. Moreover, they exhibit excellent mechanical properties: stress values up to 210 MPa and elongations up to 19% in machine (longitudinal) direction. These values clearly outperform commercial cellophane, which presents stress values of 125 MPa and elongations of 22%. The films presented herein hold great potential to become an eco-friendly and sustainable option to commercial films.
Should we embrace “Big Sister”? Smart speakers as a means to combat intimate partner violence
Authors: Sparrow Robert , Andrejevic Mark , Harris Bridget 
Published: November 2023

AbstractIt is estimated that one in three women experience intimate partner violence (IPV) across the course of their life. The popular uptake of “smart speakers” powered by sophisticated AI means that surveillance of the domestic environment is increasingly possible. Correspondingly, there are various proposals to use smart speakers to detect or report IPV. In this paper, we clarify what might be possible when it comes to combatting IPV using existing or near-term technology and also begin the project of evaluating this project both ethically and politically. We argue that the ethical landscape looks different depending on whether one is considering the decision to develop the technology or the decision to use it once it has been developed. If activists and governments wish to avoid the privatisation of responses to IPV, ubiquitous surveillance of domestic spaces, increasing the risk posed to members of minority communities by police responses to IPV, and the danger that more powerful smart speakers will be co-opted by men to control and abuse women, then they should resist the development of this technology rather than wait until these systems are developed. If it is judged that the moral urgency of IPV justifies exploring what might be possible by developing this technology, even in the face of these risks, then it will be imperative that victim-survivors from a range of demographics, as well as government and non-government stakeholders, are engaged in shaping this technology and the legislation and policies needed to regulate it.
Societal Acceptability of Insect-Based Livestock Feed: A Qualitative Study from Europe
Authors: Bunker Ingrid , Zscheischler Jana 
Published: November 2023

AbstractAgainst the background of high demand for protein-rich feed in the EU and the environmental degradation associated with intensive livestock farming, insect-based feed is discussed as a potential sustainable alternative to conventional feed. However, the establishment of such an innovation depends not only upon technical and economic feasibility, but also on social factors impacting acceptability. The aim of this paper was to determine the acceptability of different social actor groups towards the use of insects as livestock feed, and to gain insights into value-based arguments leading to positive or negative attitudes and perceived benefits and risks. By means of qualitative content analysis, we analysed responses of an EU public consultation process linked to the authorization of insect protein in pig and poultry feed. We found a broad range of value-based arguments that influence the complex judgement process of acceptability that have been neglected in prior quantitative surveys. In particular, our results bring forward more critical voices, such as animal welfare concerns and scepticism that insect-based feed can contribute to a more sustainable livestock system. Based on these findings, we discuss whether insects as feed are a viable contribution to a sustainability-oriented transformation of the agri-food system. We conclude that under certain conditions (when raised on low-value organic side streams such as manure) insect-based livestock feed may contribute to incremental sustainability improvements. Overall, however, the innovation has limitations, not only in terms of regulatory conditions but especially with regard to ethical concerns.
LiHiSTO: a comprehensive list of Hindi stopwords
Authors: Rajwal Swati 
Published: November 2023

AbstractA preliminary preprocessing step in text analytics is the removal of words with no semantic meaning, otherwise known as stopwords. English stopwords are very easily accessible and created due to the broad usability of the English language. However, a standard list of Hindi stopwords is still missing. This paper proposes an exhaustive list of generic Hindi stopwords and a Python package for easy distribution and usage. The methodology uses a dual mechanism for creating a list of Hindi stopwords. First, the famous English stopwords are collected and translated into meaningful Hindi words (group 1). Second, unique Hindi stopwords from multiple sources are fetched (group 2). Finally, the respective Hindi stopwords from groups 1 and 2 are combined, which resulted in a significantly large set of 820 Hindi stopwords. Additionally, the list of Hindi stopwords is made openly available for use at the Python Package Index (PyPI) repository as a Python package, which is named LiHiSTO. With the help of illustrative implementations, it is shown that LiHiSTO provides abstract and easy access to the list of stopwords for users to perform Hindi text analytics.
Simplifying YOLOv5 for deployment in a real crop monitoring setting
Authors: Nnadozie Emmanuel C. , Casaseca-de-la-Higuera Pablo , Iloanusi Ogechukwu , Ani Ozoemena , Alberola-López Carlos 
Published: November 2023

AbstractDeep learning-based object detection models have become a preferred choice for crop detection tasks in crop monitoring activities due to their high accuracy and generalization capabilities. However, their high computational demand and large memory footprint pose a challenge for use on mobile embedded devices deployed in crop monitoring settings. Various approaches have been taken to minimize the computational cost and reduce the size of object detection models such as channel and layer pruning, detection head searching, backbone optimization, etc. In this work, we approached computational lightening, model compression, and speed improvement by discarding one or more of the three detection scales of the YOLOv5 object detection model. Thus, we derived up to five separate fast and light models, each with only one or two detection scales. To evaluate the new models for a real crop monitoring use case, the models were deployed on NVIDIA Jetson nano and NVIDIA Jetson Orin devices. The new models achieved up to 21.4% reduction in giga floating-point operations per second (GFLOPS), 31.9% reduction in number of parameters, 30.8% reduction in model size, 28.1% increase in inference speed, with only a small average accuracy drop of 3.6%. These new models are suitable for crop detection tasks since the crops are usually of similar sizes due to the high likelihood of being in the same growth stage, thus, making it sufficient to detect the crops with just one or two detection scales.
Brainstem impairment in obstructive sleep apnoea and the effect of CPAP treatment: an electrophysiological blink reflex study
Authors: Liguori Claudio , Fernandes Mariana , Spanetta Matteo , Zanovello Martina , Giambrone Maria Pia , Lupo Clementina , Placidi Fabio , Izzi Francesca , Mercuri Nicola Biagio , Pierantozzi Mariangela 
Published: November 2023

Abstract
Purpose
This study aimed to evaluate the functionality of the brainstem structures through the blink reflex (BR) test in patients with obstructive sleep apnoea (OSA) and to assess the effects of continuous positive airway pressure (CPAP) treatment on BR responses.

Methods
Patients with moderate-severe OSA and controls underwent BR testing. Patients with OSA who were adherent to CPAP therapy repeated BR testing at 6 months follow-up. CPAP adherence was defined as CPAP use for ≥ 4 hour per night on > 5 nights per week with residual apnoea-hypopnea index less than 5 events per hour.

Results
A total of 22 patients with OSA (86% male, mean age 57.8 ± 10.6 years) and 20 controls (60% male, mean age 55.3 ± 9.3 years) were included. Patients with OSA showed longer right and left R1 latency, as well as delayed right ipsilateral and contralateral R2 latencies compared to controls. Patients with OSA who were compliant with CPAP treatment (n = 16; 88% men, mean age 58.8 ± 9.7 years) showed a significant decrease in latency of the right ipsilateral and contralateral R2 responses at 6 months.

Conclusion
This study showed an abnormal pattern of BR responses in patients with OSA, consistent with a significant impairment of brainstem functionality in OSA. CPAP treatment partially improved the BR responses, suggesting the importance of treating OSA.
Two-step inertial forward–reflected–anchored–backward splitting algorithm for solving monotone inclusion problems
Authors: Izuchukwu Chinedu , Aphane Maggie , Aremu Kazeem Olalekan 
Published: November 2023

AbstractThe main purpose of this paper is to propose and study a two-step inertial anchored version of the forward–reflected–backward splitting algorithm of Malitsky and Tam in a real Hilbert space. Our proposed algorithm converges strongly to a zero of the sum of a set-valued maximal monotone operator and a single-valued monotone Lipschitz continuous operator. It involves only one forward evaluation of the single-valued operator and one backward evaluation of the set-valued operator at each iteration; a feature that is absent in many other available strongly convergent splitting methods in the literature. Finally, we perform numerical experiments involving image restoration problem and compare our algorithm with known related strongly convergent splitting algorithms in the literature.