bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of IgG4-related hypophysitis maintained remission of diabetes insipidus for over 3 months after completion of steroid treatment
Authors: Kubori Motohiro , Fujimoto Megumi , Okauchi Yukiyoshi , Matsuno Kanae , Yamabayashi Eri , Sakamoto Ryuki , Inada Shinya , Iwahashi Hiromi 
Published: December 2023

Summary
IgG4-related disease is a multiorgan disorder in which nodules and hypertrophic lesions are observed simultaneously, or separately, in areas including the pancreas, liver, lungs, salivary glands, thyroid glands, and pituitary glands. IgG4-related hypophysis is one of several IgG4-related diseases and is characterized by pituitary gland and pituitary stalk thickening, various degrees of hypopituitarism, and increased serum IgG4 levels. Steroid therapy is effective for patients with IgG4-related hypophysis, but the reported effectiveness of steroid therapy for restoring pituitary function differs between studies. Following an episode of autoimmune pancreatitis 10 years prior, enlargement of the pituitary gland and stalk along with panhypopituitarism and polyuria developed in a 73-year-old male. A high serum IgG4 level and biopsy of the submandibular gland showing infiltration of IgG4-positive plasma cells led to a clinical diagnosis of IgG4-related hypophysitis. Prednisolone treatment reduced the swelling of the pituitary gland and stalk and improved anterior pituitary function. Although arginine vasopressin secretion remained insufficient, polyuria was relieved and kept in remission even after prednisolone treatment was completed. This is the first reported case in which prednisolone was able to maintain both normal anterior pituitary function and remission of polyuria caused by IgG4-related hypophysitis. IgG4-related hypophysitis has previously been associated with a relapse of symptoms during treatment. However, the patient reported in this case study remained in remission for over 3 months after completion of steroid treatment and should be monitored closely for changes in pituitary function.

Learning points

Steroid therapy is the first-line therapy for pituitary dysfunction and pituitary stalk swelling in IgG4-related hypophysitis.

In this case, although posterior pituitary function remained insufficient, polyuria was relieved and kept in remission for over 3 months even after prednisolone treatment was completed.

IgG4-related hypophysitis has been associated with the relapse of symptoms during steroid tapering, and changes in pituitary function and symptoms should be monitored closely.

When we encounter cases of adrenal insufficiency and polyuria during observation of autoimmune pancreatitis or other IgG4-related disease, we should consider the possibility of IgG4-related hypophysitis in mind.
Pluralidad terminológica, evaluativa y de intervención en la adicción a internet en la adolescencia: Una revisión sistemática
Authors: Raposo-Rivas Manuela , Dapía-Conde María Dolores , Rodríguez-Rivera Paula 
Published: December 2023

Objective. The study aims to analyze the scientific production on Internet addiction in adolescents. Methodology. A systematic review, following PRISMA guidelines, was conducted on articles published between 2010 and 2020 in journals indexed in PubMed, Web of Science, Scopus, and ERIC databases. To conduct the review, a parameterized search was performed using the following keywords: Internet, adolescents, addiction, treatment, prevention, education, problematic use, abusive use and excessive use. They were combined with the Boolean operator AND. After an initial identification of 319 items, 24 met inclusion criteria related to thematic appropriateness, language, and age of beneficiaries. The instruments and interventions were reviewed and analysed inductively in terms of designations, prevalence, and incidence. Results. This review revealed a lack of consensus in the terminology used and in the measuring instruments, a poor educational approach, and low effectiveness of the interventions used. Conclusions. The interest of the results obtained lies in making possible a series of recommendations that will contribute to a better approach to this problem: standardizing the terminology and conceptualization used to refer to this field of study and unifying the measuring instruments, as the current ones yield very different data. Finally, in order to help alleviate Internet addiction among adolescents, the study identified the need to develop prevention and educational intervention programs, promoted by public administrations, which allow access to all groups, especially the most vulnerable.
Effectiveness and Safety of Switching from Intravenous to Subcutaneous Vedolizumab Formulation in Inflammatory Bowel Disease Patients in Clinical Remission
Authors: Parisio Laura , Settanni Carlo Romano , Varca Simone , Laterza Lucrezia , Lopetuso Loris Riccardo , Napolitano Daniele , Schiavoni Elisa , Turchini Laura , Fanali Caterina , Alfieri Norma , Pizzoferrato Marco , Papa Alfredo , Pafundi Pia Clara , Armuzzi Alessandro , Gasbarrini Antonio , Pugliese Daniela , Scaldaferri Franco 
Published: December 2023

Background and Aims: Subcutaneous vedolizumab formulation has been shown to be as effective and safe as the intravenous one in randomized control trials. Real-life data are limited especially for patients receiving long-term intravenous therapy. This study aimed to evaluate the safety and effectiveness of switching from intravenous to subcutaneous vedolizumab in a large cohort of patients with stable clinical remission.
Methods: In this prospective cohort study, we enrolled consecutive patients attending our center between September 2021 and April 2022. The baseline demographic characteristics, 12- and 24-weeks follow-up clinical activity, C-reactive protein levels, and adverse events were recorded. The primary endpoint was to assess combined steroid-free clinical remission plus biochemical remission 24-week after the switch.
Results: 93 patients (43 Crohn’s disease, 50 ulcerative colitis), switched to subcutaneous vedolizumab after a median duration of intravenous treatment of 36 months [IQR 16-52]. At baseline, 80 patients (86%) had a combined remission. At 24-week, 89.2% (n=74) maintained combined steroid-free clinical remission plus biochemical remission. 25 adverse events were reported, mostly SARS-CoV-2 infections and injection site reactions, with a further four recurrence episodes. Twelve patients (12.9%) discontinued subcutaneous administration and restarted intravenous vedolizumab.
Conclusions: Switching from intravenous to subcutaneous vedolizumab can be considered effective and safe for maintaining remission in patients with inflammatory bowel disease. In addition, this might reduce healthcare costs. However, large-scale real-life studies with long-term follow-up are necessary.
RETHINKING HAMZAH FANSURI'S ISLAMIC COSMOLOGY
Authors: Siraj Fuad Mahbub 
Published: December 2023

This study aims to explain further the cosmological argument of Hamzah Fansuri. This research is library research using a historical approach to obtain data and conduct content analysis. According to Hamzah Fansuri, every single thing in this world that either can or cannot be seen can be pictured as a circle or curvature, the two corners of which can meet each other. Half of the curvature is “the down way curvature” (tanazzul) that is the way of the creation of the universe and its content; the manifestation process from the Oneness or the Higher Existence (Who cannot be known physically) to become many existence or the reality that can be seen physically. The other curvature is “the up-way curvature” (taraqqī), which is a way of creation from physical to metaphysical existence. The entire levels or structure of being are summarized in the person and the human being’s existence as a perfect creature of physical and spiritual quality. Therefore, the universe can only be returned to the One through humans. The concept of cosmology in the Fansuri’s thought is to show the unity and interrelationship of all existence that leads to divine oneness.
RELIGIOUS DIFFERENCE AND THE COMMON GOOD: REFLECTION ON TOLERATION AND PARTICIPATION IN CONTEMPORARY AMERICA AND INDONESIA
Authors: Ali Muhamad 
Published: December 2023

This paper seeks to discuss the extent to which religious differences can contribute to the promotion of the common good. It asks if the religious difference is sufficient for the states and the societies to attain the common good across religious and ethical persuasions in multi-faith countries such as America and Indonesia. It is primarily an ethical-philosophical question but is also related to historical, sociological, anthropological, and political contexts. For many religious people, religious particularity and distinction – including its truth and superiority claims – is a significant element of identity and sense of morality, but religious difference alone is insufficient for attaining the common good. Religions provide motivations to act good or evil. Religions offer rich resources, be doctrinal, narrative, experiential and emotional, ethical, legal, social, material, or political, but because there are many, often conflicting religious and ethical values from within the same and across religious traditions, it is not enough for everyone to share their beliefs and accept each other’s exclusive claims. For religions to help improve the public good, religious agents have to negotiate their particular and distinct identities and universal moralities and reinterpret their beliefs and norms contextually in light of the plural societies in which they live. The governments should also allow multiple voices, including the religious, by ensuring toleration, freedom of conscience and worship, and right of assembly.
Islamisasi Ilmu Pengetahuan dalam Bingkai Integrasi-Interkoneksi: Menguak Ide Islamisasi Ilmu Ismail Raji Al-Faruqi
Authors: Bistara Raha 
Published: December 2023

This article intends to examine how the concept of integration-interconnection as a formula in overcoming the skeptical secularism out of the rationalism and empiricism. The Islamization of science that was initiated by Ismasil Raji al-Faruqi is a response from the secularism indication that have spread among Muslims, both at the economic, political, cultural and scientific levels. The spread of this concept within Muslims create malaism , which only accept all things what comes from the Western. Whereas Islam as a science religion has its own characteristics that are based on the principles of Qur'an and the Sunnah. The Contradiction of This epistemological is that Muslims should be able to rise up and resist the oppression carried out by Western with their secular concept. By using the library method, this research seeks to find the answer of knowledge problems accepted by Muslims by processing data sources, both primary and secondary sources. The primary source is the original work of Ismail Raji al-Faruqi, while the most important source of sekunder is in the form of supporting data related to this research. The data processing is expected to solve the problems in Muslims understanding with scientific integration-interconnection concept. These integration-interconnection have become a very important basis for finding two opposing scientific poles, that is Islamic and secular in nature.
Pemaknaan Bumi Berbicara Menurut Mufasir Klasik dan Modern
Authors: Irfana Rizqiya , Ghazali Abdul Malik , Baihaqi Yusuf 
Published: December 2023

In the development of Quran interpretation, the approach of science has been used, which is considered the most contemporary approach to understanding verses related to the universe. Among the paradigm shifts in the interpretation of the Quran caused by the use of a scientific approach, is the emergence of an understanding of verses that were originally associated with a certain time, such as the impending apocalypse, then changed that in fact the verse is not an explanation of the events of the doomsday, such as the change in understanding of verse 4 in sura al-Zalzalah which states that at the time of the earthquake, the earth speaks to man. This article is a results of the research on the tafsir al-Jāmi’ li Ahkām al-Qur’ān by imam al-Qurṭubī and Kitab Al-Qur’an dan Tafsirnya (Edisi yang Disempurnakan) compiled by the Ministry of Religion of the Republic of Indonesia by qualitative methods. This article concludes that classical and modern exegetes have similarities in interpreting the earth speak. The equation is that when the earth is shaken it releases its burden in the form of rocks and other objects. After examining these objects, they can provide information about human actions that have occurred at certain times. The Geologists can also get information about when the earthquake occurred at a certain time from the records found on rocks and coral reefs.
The Cultural and Linguistic Diversity of Migrants in South Africa
Authors: Anthonissen Christine 
Published: December 2023

This article reflects on the position of migrants in a South African setting and on their integration in the host community, with attention paid to family religious affiliation. As an interdisciplinary contribution, it introduces the concepts of “language policy” and “family language policy” in reference to African migrants’ narratives of adults who recently moved to the Western Cape in search of security and better life chances. Multilingual repertoires shape social mobility options, and vulnerable people draw on religious ideas to interpret their life journeys while seeking a better future. Also, in maintenance of heritage languages, religion often plays a central role. The notion of “family” applied to migrant workers rarely fits traditional definitions. The paper attends to how migrants’ and refugees’ mobility affects their experiences in culturally, linguistically, and religiously diverse communities. Finally—mostly embedded in a discussion of other pertinent themes—the article indicates how migrants refer to the role of church and religion in their itineraries.
The effect of melatonin on physiological, biochemical, and enzymatic properties and the expression of antioxidant genes under different irrigation regimes in wheat
Authors: MOHAMMAD Mohammad Hasso , KHALILI Marof , HAMZE Hamze 
Published: December 2023

A split-plot experiment was conducted based on a randomized complete block design with four replications in two years to study the effect of melatonin on the biochemical properties and the gene expression related to antioxidant enzyme activity in bread wheat. Irrigation levels (normal (FC = 80%)), mild stress (FC = 60%), and severe stress (FC = 40%)) were assigned to the main plots, and melatonin foliar applications (zero, 50, 100, 150, and 200 μM) were assigned to Subplots. Results showed that, with the intensification of water stress, the 1000 kernel weight decreased, and the activity of ascorbate peroxidase enzyme and flavonoid content increased. Also, the level of 100 μM melatonin had the highest 1000 kernel weight, flavonoid content, and ascorbate peroxidase enzyme activity. In this study, the highest number of grains per spike, biological yield, grain yield, chlorophyll a, chlorophyll b, carotenoids, and the lowest amount of malondialdehyde recorded for foliar treatment with 50 μM of melatonin under normal irrigation conditions and the highest proline content, total phenol, superoxide dismutase, and catalase were allocated to the 100 μM melatonin foliar treatment under severe water stress conditions. The synergistic effect of water deficit stress and melatonin foliar application increased the activity and expression level of genes related to antioxidant enzymes. So, the content of superoxide dismutase (21.30% and 65.16% respectively) and catalase (50.60% and 54.44% respectively) enzyme activity increased significantly under 100- and 150-mM melatonin foliar application in water severe water stress compared to the corresponding control treatment. Furthermore, mentioned melatonin levels increased the gene expression levels of superoxide dismutase (16.67% and 38.19% respectively), ascorbate peroxides (73.76% and 47.57% respectively), polyphenol oxidase (39.32 and 51.15%) and catalase (39.95% and 50.0% respectively) under an extreme water shortage compared with corresponding control treatment. In general, the application of 100- and 150-mM melatonin induced resistance to water deficit stress in wheat by increasing the expression of antioxidant genes.
Effects of exogenous brassinolide and AM fungi on growth, photosynthetic characteristics and antioxidant enzyme system of Leymus chinensis under salt and alkali stress
Authors: GAO Zhanwu , LIU Jing , LI Qian , LIU Jinyu , BAI Mengyuan , LI Xinning , ZHU Qiang , CUI Yanhui , RASHEED Adnan 
Published: December 2023

Salinity and alkali stresses are a major abiotic stress negatively affecting crop productivity around the globe. Therefore, it is mandatory to develop the effective measures to mitigate the adverse impacts of these stresses for ensuring sustainable crop productivity and food security. Therefore, a pot experiment determined the effects of brassinolide application, inoculation with AM fungi (Funneliformis mosseae) and their combined use on the growth, photosynthesis and antioxidant system of Leymus chinensis under saline-alkali stress (0, 150 mmol/L). The mechanism of the two to alleviate the saline-alkali stress of L. chinensis was explored. The physiological and biochemical indexes of Leymus chinensis were significantly affected under saline-alkali stress (150 mmol/L). Inoculation of AM fungi and application of brassinolide effectively increased the biomass accumulation in the upper part (∼ 25-40%) and root (15-35%) system of L. chinensis under saline-alkali stress. Further AMF also improved photosynthetic pigments (chlorophyll a, chlorophyll b), photosynthetic rate (Pn), Intercellular CO2 concentration (Ci), stomata conductance (Gs), transpiration rate (Tr), chlorophyll fluorescence antioxidant enzymes (SOD: superoxide dismutase. CAT: catalase APX: ascorbate peroxidase, GR: Glutathione reductase) activity, and decreased malondialdehyde (MDA: ∼ 40-50%) and hydrogen peroxide (H2O2: ∼ 30-40%) accumulation. Therefore, under saline-alkali stress conditions, the combination of brassinolide and AM fungi proved better to mitigate their toxic effects.
The role of medicinal mushrooms as gastroprotective agents: A short narrative review
Authors: PUIA Aida , SCHLANGER Diana , PUIA Ion C. 
Published: December 2023

This review examines the possible clinical uses of extracts from mushrooms with medicinal properties, particularly their role as gastroprotective agents. After conducting a thorough examination of the literature, we identified and chose publications that presented six distinct types of mushroom extracts. These extracts have been experimentally demonstrated to have gastroprotective effects in animal models. Animals like rats or mice were used as subjects in experimental models to generate stomach ulcers through various approaches, such as chemical induction or inducing stress. Studies have shown that mushroom extracts are efficacious in facilitating the healing process of stomach ulcers. Several fundamental modes of action include anti-inflammatory and antioxidant effects, along with enhanced preservation of stomach mucus. No clinical trials pertaining to this topic have been uncovered. However, the initial positive outcomes gained serve as a basis for additional investigation on this subject.
A Processual Approach to Political Violence Phenomenon in Somalia: An Assessment of the Political Opportunities and Threats
Authors: ALEGÖZ Halil İbrahim 
Published: December 2023

This study investigates the political violence phenomenon in Somalia from 2001
to 2004. We assert that political violence emerges as one of the potential outcomes on
the part of an organization in a political struggle. It unfolds in a complex, multifaceted,
and contentious political setting. The political struggle may occur within the five
confrontational political milieu areas. In this article, however, we limit the scope of our
analysis to examine the social and political interactions between national political elites
and Islamic courts. We aim to assess whether these political interactions have led to a
potentially violent outcome. This article is situated within the theoretical framework
of the Contentious Politics Paradigm, initially formulated by Charles Tilly et al. and
subsequently refined by Eitan Alimi et al. as a relational radicalization framework.
Yeni Osmanlılar ve Jön Türkler’de Meşveret Kavramı (Hürriyet ve Meşveret Gazeteleri Bağlamında)
Authors: KADIOĞLU Büşra 
Published: December 2023

Meşveret kavramı Osmanlı siyasal düşüncesi ve söyleminde etkin bir yere sahiptir.
Gelenek içerisinde danışma meclisleri, istişare etme manalarını kapsayacak biçimde yer
alan kavram bilhassa Yeni Osmanlılar Cemiyeti ile politik yeni bir anlam kazanmaktadır.
Sonrasında kavramın manasının Jön Türkler vasıtasıyla siyasallığı keskinleşmekte ve
nihayetinde ise meşrutiyete uzanmaktadır. Mevcut çalışmalarda Yeni Osmanlı ve Jön Türk
düşüncesi incelenmektedir ancak bu hareketlerin meşveret kavramı yorumunun özelinde
bir kavramlar tarihi tetkiki bulunmamaktadır. Makalemizde söz konusu noksanlığı
gidermek amacıyla meşveret kavramının Yeni Osmanlı ve Jön Türk düşüncesindeki
gelişimi incelenmektedir. Yapılan inceleme Yeni Osmanlılar için Hürriyet, Jön Türkler
için ise Meşveret gazeteleri bağlamında gerçekleştirilmektedir. Tetkik nihayetinde ise
meşveretin Yeni Osmanlılar tarafından siyasal söyleme dahil edildiği ve Jön Türkler
tarafından politik niteliğinin kalıcı hale getirildiği sonucuna ulaşılmaktadır.
Birinci Dünya Savaşı’nda Yahudi Spira Ailesi: Casusluktan Siyon Katır Birliğine Osmanlı Karşıtı Faaliyetleri
Authors: SORGU Murat 
Published: December 2023

20. yüzyılda dünyada yaşanan gelişmeler siyonizm akımının güç ve taraftar
kazanmasını sağlamakla birlikte siyonistlerin var güçleriyle Filistin’e yönelmelerine de
neden olmuştur. Osmanlı Yahudi toplumunun bir kısmını etkisi altına alan bu akım sadece
teorik bir bilgi değil aynı zamanda uygulamaya dönüşen bir ideoloji hâline de dönüşmüştür.
Bu akıma mensup Yahudiler, birçok alanda olduğu gibi casusluk faaliyetleri yürüterek
Yahudi Devleti’nin kurulmasına gayret göstermişlerdir. Bu çerçevede Filistin’de bulunan
casus Spira Ailesi’nin faaliyetleri önem arz etmektedir. Almanya’dan Osmanlı Lahey
Sefareti’ne gönderilen bir mektupla deşifre edilen Spira Ailesi, Filistin’de siyonizm lehine
siyasi, ekonomik ve toplumsal olduğu kadar askeri faaliyetlerde de bulunmuştur. Ne var
ki bu faaliyet sahası Filistin ile sınırlı kalmamış, Almanya, İngiltere ve Hollanda’ya da
yayılmıştır. Zamansal olarak Birinci Dünya Savaşı’ndan önce casusluk faaliyetlerine
başlayan Spira Ailesi, savaş boyunca aktif durumda kalmıştır. Bu faaliyetlerinin 1918
yılı Mart ayına kadar sürdüğü ve bu tarihlerde 4. Ordu’ya bağlı istihbarat birimlerinin
operasyonu ile ailenin etkisiz hale getirildiği anlaşılmıştır. Bu çalışmada Birinci Dünya
Savaşı sürecinde Osmanlı Devleti’nde ve farklı ülkelerde organize olan Spira Ailesi’nin
casusluk faaliyetleri Osmanlı arşiv vesikaları ışığında incelenmiştir.