bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of oncologic pathways in cervical cancer and the correlation with dietary factors: insights into molecular mechanisms and nutritional influences.
Authors: Debora Chris Kezia  , Aiko Zavira Permana  , Naura Luviezka Choirunnisa  , Happy Kurnia Permatasari  , Hikmawan Wahyu Sulistomo  , Holipah  , Nik Ahmad Nizam Nik Malek  
Published: February 2025

Introduction: Cancer is currently the second greatest cause of death worldwide. Cervical cancer, the second most common malignancy in women worldwide, is characterized by dysregulated oncologic pathways contributing to its progression.
Goals : This systematic review aims to explore the role of different oncologic pathways in cervical cancer progression and the impact of diet on these pathways.
Methods: A systematic literature review was conducted using the PRISMA system and flow charts for quality assurance. The PICOS framework was used for inclusion criteria. Keywords used in six databases included ("signaling pathway") AND ("pathology") AND ("oncogenic") AND ("cervical cancer"). A risk of bias assessment was conducted on selected studies using the QUIN tool for in vitro studies.
Results: Nineteen studies were analyzed. Desired outcomes included induced proliferation, inhibited apoptosis, invasion-metastasis promotion, and angiogenesis. Identified oncologic pathways based on these outcomes include P53, TNF-mediated, FOXM1/WNT/β-catenin, EGFR, VEGF, NF-κB, Her-2, Histone 3, ERCC1, JAK/STAT, TGF-β, ErbB, BMP4/Hippo/ YAP1/TAZ, and ERK/c-Myc pathways. Nutritional factors, such as a western diet with processed meats, salty foods, chips, red meat, and instant foods, were found to affect the hyperactivation of these oncologic pathways, increasing cervical cancer risk.
Discussion: Each oncologic pathway has distinct mechanisms but some share similarities in triggering tumorigenesis. Increased proliferation results from heightened cell cycle activity and reduced tumor suppressor gene function. The suppression of caspase activity and pro-apoptotic proteins causes apoptosis inhibition. Metastasis and angiogenesis are driven by elevated expression of EMT and MMP proteins, promoting cancer cell invasion, migration, and new blood vessel formation. Nutritional factors influence these pathways, emphasizing the role of diet in cervical cancer progression and prevention.
Conclusion: Various and interconnected mechanisms underlie specific oncologic pathways impacting cervical cancer. Diet significantly influences the hyperactivation or inactivation of cancer-related pathways, affecting cervical cancer risk.

KEYWORDS
Cervical cancer, oncological pathway, dietary factors
Efecto de la suspensión de semilla Moringa oleifera Lam frente a la neurotoxicidad inducida por etanol en ratones.
Authors: Flores Castro Lorena Margot , PINTO GONZA JOHN HENRY , Huamán Gutiérrez Oscar Gustavo 
Published: February 2025

Objetivo: Evaluar el efecto de la suspensión de semilla Moringa oleifera Lam frente a la neurotoxicidad inducida por etanol en ratones. Metodología: Estudio de diseño experimental. Se emplearon 35 ratones macho, y semillas de Moringa oleífera Lam (moringa), la cual fe triturada en mortero con agua en cada día del ensayo. Los animales fueron distribuidos en cinco grupos y recibieron el siguiente tratamiento por 15 días, grupo I-II agua (10 mL/kg de peso), grupo III vitamina E (20 UI/kg), grupo IV suspensión de semilla moringa (200 mg/kg), grupo V suspensión de semilla moringa (600 mg/kg). A los grupos II-V se le administró etanol 40% por vía intraperitoneal. Al culminar el tratamiento se extrajeron el cerebro y cerebelo para los análisis bioquímicos e histológicos. Se aplicó la prueba ANOVA y los valores que presenten p< 0.05 se consideran significativos. Resultados: En los grupos IV-V se observó una tendencia al aumento en los niveles de grupos sulfhídrilos proteicos (p<0,05) y una disminución en los niveles de lipoperoxidación. A nivel histológico se observó la conservación del tejido cerebral y cerebeloso. Conclusión: La administración de suspensión de semilla Moringa oleifera Lam presentó efecto neuroprotector expresado en la disminución de los niveles de lipoperoxidación, aumento de los grupos sulfhídrilos proteicos y la preservación histológica frente a la toxicidad inducida por etanol en ratones.
Comparación del estado nutricional antropométrico y consumo de alimentos en niños vegetarianos y omnívoros en una región de Colombia
Authors: Gómez Ramírez Briana , Cárdenas Sánchez Diana , Sepúlveda Bustamante Cindy , Rodríguez Rueda Valentina , Narváez Rivas Ana María 
Published: February 2025

Introducción: En la actualidad hay un aumento de familias que con sus hijos tienen una alimentación basada en plantas. El estado nutricional por antropometría y el consumo de alimentos se ha realizado en niños en países desarrollados, pero poco se conoce de países en vías al desarrollo.
Objetivo: comparar el estado nutricional antropométrico y el consumo alimentario de niños y niñas menores de 12 años de familias vegetarianas y omnívoras del Valle de Aburrá, Colombia.
Materiales y Métodos: Se realizó un estudio analítico, transversal con comparación de grupos pareados por edad, género y nivel socioeconómico. Los grupos estaban conformados por niños vegetarianos y omnívoros entre 6 meses y 12 años. Se analizaron medidas antropométricas, estado nutricional y consumo alimentario en ambos grupos.
Resultados: La diferencia de peso entre grupos fue 1,6 kg y de talla 4,5 cm, siendo más bajo en vegetarianos, no obstante, estaban dentro de la normalidad en el estado nutricional. La población vegetariana tiene un mayor consumo de fibra, vitamina C y folato, aunque menor aporte de proteínas, calcio y cobalamina comparado con la población omnívora. Los resultados obtenidos en el presente estudio muestran que los niños y las niñas de familias vegetarianas no tienen riesgos nutricionales específicos más allá de los que tendría la población omnívora.
Conclusión: Se debe hacer énfasis en la vigilancia de los niños vegetarianos en cuanto a la talla y en el consumo suficiente de proteína, calcio y cobalamina, aunque este último micronutriente será cubierto por la suplementación recomendada para este grupo de edad. En comparación con otros estudios se identifica con un consumo comparable, sin embargo, los puntos de corte de nutrientes son un poco más exigente para países en vías de desarrollo.
Household food insecurity and nutritional status of toddler in Central Lombok.
Authors: Khairul Abdi Lalu , Lalu Juntra Utama  , I Gde Narda Widiada I Gde Narda Widiada , Lina Yunita  
Published: February 2025

Background: Food insecurity can cause nutritional problems, especially in toddlerhood, where at this time nutritious intake is needed because at this time children experience growth that can have an impact on their adulthood. Food insecurity can stem from income poverty which negatively impacts overall household consumption levels. Therefore, the condition of food insecurity causes malnutrition so the purpose of this study is to assess household food insecurity and nutritional status of toddlers in central Lombok, West Nusa Tenggara.
Methods: The design of this research was a cross-sectional study; data collection was carried out in Central Lombok Regency, West Nusa Tenggara Province, Indonesia. This research involved two groups of subjects: toddlers and father or mother caregiver. The total number of subjects was 391 toddler include the household . Subjects were taken at each community health center using a simple random method without replacement. All primary data was collected through an interview process using a structured questionnaire and direct measurements. The analysis process for all types of data was carried out with the help of the SPSS for Windows program with the Pearson correlation test and One Way Anova test.
Results: This study presents that as many as 60.1% of households in Central Lombok experience food insecurity at mild, moderate and severe levels. Which can be caused by due to low monthly household income and social assistance. Although the results of the analysis showed that no significant relationship was found (p>0,05) between the household food insecurity score and the anthropometric of the nutritional status of the toddlers almost half of the undernourished toddlers were included in the food-insecure.
Conclusions:. High rate of food insecurity that occurs then, for increased access to food especially during period of rapid development and growth to overcome malnutrition so that can prevent bad impact in the future.
Efecto del pulverizado de Chenopodium ambrosioides (paico) sobre los marcadores del metabolismo lipídico en hígado de ratas, frente al consumo de etanol y fructosa.
Authors: Puelles Samaniego Olenka , Huamán Gutiérrez Óscar Gustavo , Turriate Aguilar Paula Sofía 
Published: February 2025

Introducción: Las enfermedades hepáticas crónicas (EHC) presentan una tasa elevada de morbimortalidad en el mundo, con una alarmante tendencia creciente; siendo la cirrosis hepática el estadio final y la expresión crónica más frecuente respecto a las hepatopatías. Objetivo: Evaluar el efecto del pulverizado de Chenopodium ambrosioides (paico) frente al consumo de etanol y fructosa en hígado de ratas. Materiales y métodos: Diseño experimental. Se empleó 25 ratas macho. Para la inducción a la hepatotoxicidad, la cual duró 22 días, se administró una mezcla de etanol 5% /fructosa 15% en sus bebederos a los grupos II-V, mientras que el grupo I recibió solo agua. A partir de la dieta balanceada se agregó el pulverizado de paico 1% (grupo III), 3% (grupo IV) y 9% (grupo V), mientras el grupo I-II recibieron solo dieta balanceada, dicho tratamiento fue por 22 dias. Terminado el tratamiento y tras 10 horas de ayuno, los animales fueron anestesiados con pentobarbital sódico, para posteriormente extraer el hígado, el cual se seccionó tres porciones, para el análisis histológico, y dos para la preparación de homogenizado en donde se determinó los marcadores moleculares. Resultados: El consumo de paico 3% incrementó los niveles de PPAR-α, mientras el PPAR- γ se incrementó en los grupos III, IV y V. El SREBP tuvo mayor inhibición al 3% de paico. La relación PPAR-α /SREBP y Ppar- γ /SREBP aumentó en relación el porcentaje de paico. Conclusiones: El consumo del pulverizado de Chenopodium ambrosioides (paico) presenta efecto hepatoprotector a dosis media para el modelo estudiado.
Transformación de residuos de frutas y verduras en alimentos saludables y sostenibles y su impacto en la salud de las personas mayores.
Authors: Rodriguez Palleres Ximena , Rojas González Fancy , Toledo San Marín Álvaro , Castagnini Juan Manuel 
Published: February 2025

RESUMEN
Introducción: El desperdicio de frutas y verduras tiene un impacto ambiental, nutricional y social que afecta la seguridad alimentaria de la población, principalmente de las personas mayores.
Objetivo: Analizar el efecto de la ingesta de alimentos saludables y sustentables provenientes de excedentes agroalimentarios sobre la salud de personas mayores en Chile a través de parámetros nutricionales y bioquímicos.
Métodos: Estudio de intervención nutricional. Participaron 45 adultos mayores, divididos en un grupo control y un grupo de intervención. En el grupo de intervención se incorporaron prototipos de alimentos elaborados a partir de residuos de frutas y verduras a la dieta diaria durante 60 días. Se realizaron evaluaciones de ingesta dietética, mediciones antropométricas y análisis de sangre antes y después de la intervención a ambos grupos.
Resultados: La prevalencia de obesidad y sobrepeso post intervención fue de 40,9% en el grupo intervenido y de 30.4%, en el grupo control. En el grupo de intervención, la ingesta de frutas aumentó a 137.50 gramos (p=1.824e-06*) y verduras aumentó a 229.55 (p=1.019e-07*) después de la intervención, con diferencias significativas. Las vitaminas A (0.74 mg/L, p=0.707) y C (5.39 mg/L, p=0.647) aumentaron en el grupo de intervención después de la intervención, pero sin diferencias significativas. El colesterol total (168.5 mg/L, p=0.734) y el colesterol LDL (96.34 p=0.769) disminuyeron en el grupo de intervención después de la intervención, pero sin diferencias significativas.
Conclusión: Primer estudio que muestra la ingesta de alimentos saludables y sostenibles elaborados a partir de residuos de frutas y verduras y su impacto en el estado de salud de las personas mayores.
Incidence trends and risk factors for Perthes’ disease in children born between 1985 and 2016
Authors: Hedley Paula L. , Lausten-Thomsen Ulrik , Conway Kristin M. , Hindsø Klaus , Romitti Paul A. , Christiansen Michael 
Published: February 2025

AimsIn this study, we aimed to evaluate incidence trends and potential risk factors associated with Perthes’ disease in Denmark, using publicly available data.MethodsOur population-based case-control study used data from the Danish National Patient Register and Danish Civil Registration System, accessed through the publicly available Danish Biobank Register, to identify 1,924,292 infants born between 1985 and 2016. We estimated age-specific incidence rates for four birth periods of equal duration (1985 to 1992, 1993 to 2000, 2001 to 2008, and 2009 to 2016) and investigated associations with perinatal conditions, congenital malformations, coagulation defects, autism spectrum disorders (ASD), and attention deficit hyperactivity disorders (ADHD).ResultsWe identified 2,374 (81.6% male) diagnosed with Perthes’ disease aged between two and 12 years, corresponding to an overall incidence of 12.1 per 100,000 live births relative to the year of birth. The incidence declined across all four birth periods, irrespective of sex or age at diagnosis. Several perinatal conditions were associated with higher Perthes’ disease risk. Children with reported birth injuries (vs no reported injuries) exhibited the highest risk (relative risk (RR) 7.48 (95% CI 3.37 to 16.63)) followed by those with versus without coagulation defects (RR 4.77 (95% CI 1.79 to 12.69)). Children diagnosed with syndromic (RR 2.90 (95% CI 2.08 to 4.04)) or non-syndromic major congenital malformations (RR 1.86 (95% CI 1.55 to 2.23)) (vs those with no malformation diagnosis) were also associated with higher Perthes’ disease risk. The development of Perthes’ disease was positively associated with several ASD and ADHD diagnoses. However, once adjusting for the sex of the child and period of birth, the associations with ASD and ADHD were no longer significant.ConclusionUsing publicly available data, we observed a declining incidence of Perthes’ disease in Denmark over a 32-year study period. Our findings also confirm positive associations between Perthes’ disease and various perinatal conditions, coagulation defects, and congenital malformations, highlighting potential aetiological pathways for further investigation.Cite this article: Bone Joint J 2025;107-B(2):268–276.
Assessing the Wrightington Classification System for elbow fracture-dislocations
Authors: Tse Shannon , Van de Kelft An-Sofie , Simister Samuel K. , Forster Danielle A. , Lee Marcus , Prinja Aditya , Rajesparan Kannan , Rashid Abbas 
Published: February 2025

AimsComplex elbow fracture-dislocations often result in suboptimal outcomes and necessitate a thorough understanding of injury patterns to guide effective management and reduce adverse sequelae. The Wrightington Classification System (WCS) offers a comprehensive approach and considers both bony and soft-tissue disruption, providing clearer guidance for treatment. This is the first external study to assess the reliability of the WCS for elbow fracture-dislocations.MethodsA blinded study of patients with elbow fracture-dislocations at a single institution between December 2014 and December 2022 was conducted. Five assessors with a range of experience, including orthopaedic surgeons and radiologists, independently classified injuries using the WCS across three image methods: plain radiograph, 2D CT, and 2D and 3D CT reconstruction images, on two occasions with an eight-week interval. Interobserver and intraobserver reliability were evaluated using kappa statistics and the Landis and Koch criteria.ResultsA total of 73 patients were included in the study. Interobserver reliability was moderate, with mean kappa values of 0.518 (95% CI 0.499 to 0.537), 0.557 (95% CI 0.537 to 0.577), and 0.582 (95% CI 0.562 to 0.601), for radiographs, 2D CT, and 2D and 3D CT reconstructions, respectively. Intraobserver agreement was substantial (mean kappa 0.695 (SE 0.067), 0.729 (SE 0.071), and 0.777 (SE 0.070) for radiographs, 2D CT, and 3D CT reconstructions, respectively).ConclusionThe WCS is a reliable and valuable tool for characterizing elbow fracture-dislocations and guiding surgical interventions. This study found moderate reliability in using the WCS, with higher reliability with combined 2D and 3D CT imaging. Further refinement within the WCS in differentiating between coronoid avulsions, basal, anteromedial, and/or anterolateral facet injuries may help improve reliability and reproducibility.Cite this article: Bone Joint J 2025;107-B(2):188–192.
3D fracture assessment could be predictive of native hip survival after nonoperative treatment of acetabular fractures
Authors: Trouwborst Neeltje M. , Oldhoff Miriam. G. E. , ten Duis Kaj , van Helden Sven H. , Hermans Erik , Jaarsma Ruurd L. , van Lieshout Esther M. M. , Reininga Inge H. F. , Tromp Tjarda N. , Verhofstad Michael H. J. , de Vries Jean-Paul P. M. , Wijffels Mathieu M. E. , Meesters Anne M. L. , IJpma Frank F. A. 
Published: February 2025

AimsThe aim of the study was to apply 3D measurements for fracture displacement in minimally to moderately displaced acetabular fractures treated nonoperatively, and to evaluate whether this measurement can be used to estimate the likelihood of conversion to total hip arthroplasty (THA) at follow-up.MethodsA multicentre, cross-sectional study was performed on 144 patients who were treated nonoperatively for an acetabular fracture in four level 1 trauma centres between January 2000 and December 2020. For each patient, fracture displacement was measured on CT-based 3D models. The 3D gap area represents fracture displacement (mm2) between all fracture fragments. A receiver operating characteristic curve was generated to determine a 3D gap area threshold representing the optimal sensitivity and specificity to predict conversion to THA. Native hip survival was reported using Kaplan-Meier curves. Predictors of conversion to THA were determined using Cox regression analysis.ResultsOf 144 patients, 18 (12%) received a THA. The median 3D gap area of the complete study cohort was 692 mm2 (IQR 216 to 1,400). Native hip survival in patients with a gap area threshold ≤ 1,171 or > 1,171 mm2 differed at one-year (98% vs 85%), two-year (96% vs 77%), and five-year follow-up (92% vs 73%). 3D gap area > 1,171 mm2 (hazard ratio (HR) 4.3; 95% CI 1.7 to 11.0) and the presence of osteoarthritis grade 2 or higher (HR 3.1; 95% CI 1.2 to 7.8) independently predicted the likelihood of conversion to THA during follow-up.ConclusionFor nonoperatively treated acetabular fractures, introducing 3D gap area assessment to measure fracture displacement offers a promising approach for assessing the risk of conversion to THA. With the introduction of (semi-)automatic segmentation and measurement techniques, or their implementation into commercially available software, this 3D gap area measurement can serve as an addition to the Letournel classification and an alternative to traditional 2D gap and step-off measurements, improving accuracy, reproducibility, and applicability in clinical decision-making.Cite this article: Bone Joint J 2025;107-B(2):204–212.
Acetabular component position significantly influences the rebalancing of pelvic sagittal inclination following total hip arthroplasty in patients with Crowe type III/IV developmental dysplasia of the hip
Authors: Du Han , Qiao Han , Zhai Zan-jing , Zhang Jing-wei , Li Hui-wu , Mao Yuan-qing , Zhu Zhen-an , Zhao Jie , Yu De-gang , Zhao Chang-qing 
Published: February 2025

AimsSagittal lumbar pelvic alignment alters with posterior pelvic tilt (PT) following total hip arthroplasty (THA) for developmental dysplasia of the hip (DDH). The individual value of pelvic sagittal inclination (PSI) following rebalancing of lumbar-pelvic alignment is unknown. In different populations, PT regresses in a linear relationship with pelvic incidence (PI). PSI and PT have a direct relationship to each other via a fixed individual angle ∠γ. This study aimed to investigate whether the new PI created by acetabular component positioning during THA also has a linear regression relationship with PT/PSI when lumbar-pelvic alignment rebalances postoperatively in patients with Crowe type III/IV DDH.MethodsUsing SPINEPARA software, we measured the pelvic sagittal parameters including PI, PT, and PSI in 61 patients with Crowe III/IV DDH. Both PSI and PT represent the pelvic tilt state, and the difference between their values is ∠γ (PT = PSI + ∠γ). The regression equation between PI and PT at one year after THA was established. By substituting ∠γ, the relationship between PI and PSI was also established. The Bland-Altman method was used to evaluate the consistency between the PSI calculated by the linear regression equation (ePSI) and the actual PSI (aPSI) measured one year postoperatively.ResultsThe mean PT and PSI changed from preoperative values of 7.0° (SD 6.5°) and -8.0° (SD 6.7°), respectively, to 8.4° (SD 5.5°) and -4.5° (SD 5.9°) at one year postoperatively. This change shows that the pelvis tilted posteriorly following THA. In addition, when lumbar-pelvic alignment rebalanced, the linear regression equation between PI and PT was PT = 0.45 × PI - 10.5°, and PSI could be expressed as PSI = 0.45 × PI - 10.5° - ∠γ. The absolute difference between ePSI and aPSI was less than 5° in 55 of 61 patients (90.16%).ConclusionThe new PI created by the positioning of the acetabular component significantly affects the PSI when lumbar-pelvic alignment changes and rebalances after THA in patients with Crowe III/IV DDH.Cite this article: Bone Joint J 2025;107-B(2):149–156.