bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the clinical efficacy and mechanism of high-position colon dialysis combined with Traditional Chinese Medicine retention enema in real-world patients with stage 3–5 chronic kidney disease (non-dialysis) based on the theory of the Gut–Kidney axis
Authors: Deng Yanli , Zhang Leixiao , Chen Si , Xu Dongxian , Wu Wei , Shen Tao , Liu Zhen , Yang Lin , Wen Aiwei , Hou Yuhao , Shao Fanyun 
Published: January 2024

Background: With societal and economic development, the annual incidence of chronic kidney disease (CKD) is increasing. Current treatments for CKD are limited, and once patients progress to the uraemic stage, it places a significant economic burden on families and society. Based on the “gut–kidney axis” theory and real-world research, this study aims to evaluate the clinical efficacy, safety, and potential mechanism of high-position colon dialysis combined with traditional Chinese medicine (TCM) retention enema in treating stage 3–5 chronic kidney disease (non-dialysis). Additionally, it seeks to identify new therapeutic targets and approaches for CKD treatment.Methods: The TCM decoction was analyzed using Ultra-Performance Liquid Chromatography-Quadrupole-Orbitrap-High Resolution Mass Spectrometry (UPLC-Q-Orbitrap-HRMS). Participants meeting the inclusion criteria were divided into a control group (n = 153) and a treatment group (n = 159) based on their preferences and physicians’ recommendations. Both groups adhered to a high-quality low-protein, low-salt, low-phosphorus, and low-fat diet supplemented with essential amino acids, and were monitored for blood pressure, blood glucose, and blood lipids. The treatment group received high-position colon dialysis combined with TCM retention enemas (administered at least 12 times every other day).Results: Thirteen compounds were identified from the herbs by UPLC-Q-Orbitrap-HRMS. The CKD3–5 treatment group exhibited improvements in blood biochemistry and other laboratory indices, with significant enhancements in renal function-related indices for CKD4 and CKD5 stages (p &lt; 0.05). Following treatment, indoxyl sulfate (IS), endotoxin, and D-lactic acid levels decreased to a certain extent in both groups, with a statistically significant difference observed within the treatment group (p &lt; 0.05). The treatment group displayed a significant reduction in aerobic bacterial colonies, an increase in anaerobic bacterial colonies, a decrease in Escherichia coli colonies, and an increase in Bifidobacterium and Lactobacillus colonies (p &lt; 0.05). No significant changes in colony numbers were observed in the control group.Conclusion: High-position colon dialysis combined with TCM retention enema may serve as an adjuvant treatment for CKD4-5 (non-dialysis), and its mechanism may be related to the reduction of uraemic toxins, improvement of intestinal mucosal barrier function, and regulation of intestinal microecology.Clinical Trial Registration:https://www.chictr.org.cn/, identifier ChiCTR2200062852.
Effects of yeast extract supplemented in diet on growth performance, digestibility, intestinal histology, and the antioxidant capacity of the juvenile turbot (Scophthalmus maximus)
Authors: Sun Jingwu , Li Yahui , Ren Tiancong , Gao Qian , Yin Lingqi , Liang Yunzhi , Liu Haiyan 
Published: January 2024

An 8-week feeding experiment was conducted on the juvenile turbot (Scophthalmus maximus) to evaluate the influence of yeast extract (YE) supplementation in the diet on growth performance, feed utilization, body composition, nutrient digestibility, intestinal histology, and antioxidant capacity. Four experimental diets were formulated with graded levels of yeast extract 0 (YE0), 1% (YE1), 3% (YE3), and 5% (YE5) and fed to turbots (initial body weight: 4.2 ± 0.1 g) with three replicates per diet and 200 fish in each replicate, respectively. The results showed that turbots fed with diets YE1 and YE3 displayed a significantly higher specific growth rate and protein efficiency rate than those fed with diets YE0 and YE5, while the feed conversion ratios in YE1 and YE3 groups were lower than those in YE0 and YE5. Fish fed with diets YE3 and YE5 showed higher body crude protein contents than those in groups YE0 and YE1. The highest apparent digestibility coefficients for dry matter and crude protein, digestive enzyme activities (trypsin, lipase, and amylase), and the height of the intestinal fold were observed in the YE3 group. YE3 treatment displayed a significantly higher superoxide dismutase (SOD) activity than the YE0 group, while the malondialdehyde (MDA) content in YE1 was significantly lower than those in YE0 and YE5. No significant difference was observed in serum physiological and biochemical parameters among all treatments. Overall, appropriate dietary supplementation of the yeast extract could improve the growth performance, digestibility, and antioxidant capacity of the juvenile turbot, and the recommended yeast extract level in the feed is 2.47%.
An insight into the different responses to salt stress in growth characteristics of two legume species during seedling growth
Authors: Mi Jia , Ren Xinyue , Shi Jing , Wang Fei , Wang Qianju , Pang Haiyan , Kang Lifang , Wang Changhui 
Published: January 2024

Legumes play a crucial role in the restoration and utilization of salinized grassland. To explore the physiological response mechanism of Astragalus membranaceus and Medicago sativa seedlings to salt stress, salt stress culture experiments with five NaCl concentration treatments (0 mmol/L, 50 mmol/L, 100 mmol/L, 200 mmol/L, and 300 mmol/L) were conducted on these two legume seedlings. Morphological characteristics, physiological features, biomass, and the protective enzyme system were measured for both seedlings. Correlation analysis, principal component analysis (PCA), and membership function analysis (MFA) were conducted for each index. Structural equation modeling (SEM) was employed to analyze the salt stress pathways of plants. The results indicated that number of primary branches (PBN), ascorbate peroxidase (APX) activity in stems and leaves, catalase (CAT) activity in roots, etc. were identified as the primary indicators for evaluating the salt tolerance of A. membranaceus during its seedling growth period. And CAT and peroxidase (POD) activity in roots, POD and superoxide dismutase (SOD) activity in stems and leaves, etc. were identified as the primary indicators for evaluating the salt tolerance of M. sativa during its growth period. Plant morphological characteristics, physiological indexes, and underground biomass (UGB) were directly affected by salinity, while physiological indexes indirectly affected the degree of leaf succulence (LSD). Regarding the response of the protective enzyme system to salt stress, the activity of POD and APX increased in A. membranaceus, while the activity of CAT increased in M. sativa. Our findings suggest that salt stress directly affects the growth strategies of legumes. Furthermore, the response of the protective enzyme system and potential cell membrane damage to salinity were very different in the two legumes.
Burnout in residents during the first wave of the COVID-19 pandemic: a systematic review and meta-analysis
Authors: Navinés Ricard , Olive Victoria , Hidalgo-Mazzei Diego , Langohr Klaus , Vieta Eduard , Martin-Santos Rocio 
Published: January 2024

IntroductionThe high prevalence of burnout in resident physicians is expected to have increased as a result of the expansion of the pandemic. We conducted a systematic review with a meta-analysis of studies conducted during the first wave of the COVID-19 pandemic on burnout in residents and potential associated risk factors.MethodsThe search was done in the Web of Science, MEDLINE, Scopus, and Lillac databases (April 2020–October 2021) using a priori protocol based on the PRISMA guidelines. The Newcastle Ottawa Scale was used to assess the risk of bias in the included studies. We estimated the pooled prevalence (95% CI) of burnout and the prevalence ratio (95% CI) of each risk factor associated.ResultsWe included 23 studies from 451 potential initial articles and those written in the English language; all of the collected studies were cross-sectional with anonymous online surveys, involving 4,998 responders (34%), of which 53.2% were female responders, 51% were R1-2, and 71% were in direct contact with COVID-19 patients. Eighty-seven percent presented a low-to-moderate risk of bias. Publication bias was not shown. The estimated pooled prevalence of burnout was 40% (95% CI = 0.26 – 0.57). Burnout was associated with psychiatry history (PR = 4.60, 95% CI = 1.06 – 20.06). There were no differences by gender, civil status, children in-charge, year of residency, or time exposure to COVID-19.DiscussionThe overall prevalence of burnout in residents during the first wave of the pandemic was in line with the results described in this collective before the pandemic. The presence of a psychiatry history was a potential burnout risk factor, suggesting a high vulnerability during the peak of the stress period and the need to implement mental health surveillance for this subgroup.
The association between neuroendocrine/glucose metabolism and clinical outcomes and disease course in different clinical states of bipolar disorders
Authors: Zhang Xu , Zhou Yaling , Chen Yuexin , Zhao Shengnan , Zhou Bo , Sun Xueli 
Published: January 2024

ObjectiveThe treatment of bipolar disorder (BD) remains challenging. The study evaluated the impact of the hypothalamic–pituitary–adrenal (HPA) axis/hypothalamic–pituitary-thyroid (HPT) axis and glucose metabolism on the clinical outcomes in patients with bipolar depression (BD-D) and manic bipolar (BD-M) disorders.MethodsThe research design involved a longitudinal prospective study. A total of 500 BD patients aged between 18 and 65 years treated in 15 hospitals located in Western China were enrolled in the study. The Young Mania Rating Scale (YMRS) and Montgomery and Asberg Depression Rating Scale (MADRS) were used to assess the BD symptoms. An effective treatment response was defined as a reduction in the symptom score of more than 25% after 12 weeks of treatment. The score of symptoms was correlated with the homeostatic model assessment of insulin resistance (HOMA-IR) index, the HPA axis hormone levels (adrenocorticotropic hormone (ACTH) and cortisol), and the HPT axis hormone levels (thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free triiodothyronine (fT3), and free thyroxine (fT4)).ResultsIn the BD-M group, the YMRS was positively correlated with baseline T4 (r = 0.349, p = 0.010) and fT4 (r = 0.335, p = 0.013) and negatively correlated with fasting insulin (r = −0.289, p = 0.013). The pre-treatment HOMA-IR was significantly correlated with adverse course (p = 0.045, OR = 0.728). In the BD-D group, the baseline MADRS was significantly positively correlated with baseline fT3 (r = 0.223, p = 0.032) and fT4 (r = 0.315, p = 0.002), while baseline T3 (p = 0.032, OR = 5.071) was significantly positively related to treatment response.ConclusionThe HPT axis and glucose metabolism were closely associated with clinical outcomes at 12 weeks in both BD-D and BD-M groups. If confirmed in further longitudinal studies, monitoring T3 in BD-D patients and HOMA-IR for BD-M could be used as potential treatment response biomarkers.
Prevalence, antimicrobial susceptibility profile, and associated risk factors of uropathogenic Escherichia coli among pregnant women attending Dr. Sumait Hospital Mogadishu, Somalia
Authors: Mohamed Fartun Yasin , Dahie Hassan Abdullahi , Mohamoud Jamal Hassan , Adam Mohamed Hussein , Dirie Hassan Mohamud 
Published: January 2024

BackgroundUropathogenic Escherichia coli (UPEC) is a strain of E. coli commonly associated with urinary tract infections. In addition, antibiotic resistance in UPEC is one of the most significant health problems. This study was conducted to determine the prevalence, antimicrobial resistance, and factors linked to uropathogenic Escherichia coli (UPEC) in pregnant women.MethodsThis cross-sectional study was conducted within a hospital setting between August 2022 and December 2022. Using consecutive convenient sampling, the research enrolled 220 pregnant women. The urine samples obtained from these women were cultured on MacConkey and blood agar and incubated at 37°C overnight, followed by sub-culturing on Mueller Hinton media. Bacterial identification involved Gram staining and biochemical characterization (TSI, indole, citrate, methyl red, urea agar, and motility tests). Conversely, susceptibility tests were performed using the Kirby–Bauer disk diffusion method. A binary logistic regression model and analysis of odds ratios (ORs) were employed to evaluate the risk factors associated with E. coli infection, and statistical significance was attributed to p-values of ≤0.05.ResultsOut of the 220 urine samples examined, 42 (19%) exhibited a positive culture, indicating an E. coli infection in pregnant women. Our analysis revealed that income, gestational age, and history of UTIs were identified as risk factors associated with E. coli infection. Most E. coli isolates demonstrated sensitivity to amikacin (100%), nitrofurantoin (85.7%), amoxicillin/clavulanic acid, and meropenem (83.3%).ConclusionThe prevalence of E. coli was remarkable. It could be recommended that pregnant women in antenatal care have routine culture and antimicrobial susceptibility tests to prevent transmission of resistant pathogens and complications in both pregnant mothers and the unborn baby.
Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Traoré Fatoumata Bintou , Sidibé Cheick Sidya , Diallo El Hadj Marouf , Camara Bienvenu Salim , Sidibé Sidikiba , Diallo Alhassane , Diarra Nielé Hawa , Ly Birama Apho , Ag Ahmed Mohamed Ali , Kayentao Kassoum , Touré Abdoulaye , Camara Alioune , Delamou Alexandre , Sangho Hamadoun , Terera Ibrahim 
Published: January 2024

ObjectivesThis study aimed to determine the prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa.MethodsThis systematic review and meta-analysis used the PRISMA guideline on sepsis data in sub-Saharan Africa. The bibliographic search was carried out on the following databases: Medline/PubMed, Cochrane Library, African Index Medicus, and Google Scholar. Additionally, the reference lists of the included studies were screened for potentially relevant studies. The last search was conducted on 15 October 2022. The Joanna Briggs Institute quality assessment checklist was applied for critical appraisal. Estimates of the prevalence of maternal and neonatal sepsis were pooled using a random-effects meta-analysis model. Heterogeneity between studies was estimated using the Q statistic and the I2 statistic. The funnel plot and Egger’s regression test were used to assess the publication bias.ResultsA total of 39 studies were included in our review: 32 studies on neonatal sepsis and 7 studies on maternal sepsis. The overall pooled prevalence of maternal and neonatal sepsis in Sub-Saharan Africa was 19.21% (95% CI, 11.46–26.97) and 36.02% (CI: 26.68–45.36), respectively. The meta-analyses revealed that Apgar score &lt; 7 (OR: 2.4, 95% CI: 1.6–3.5), meconium in the amniotic fluid (OR: 2.9, 95% CI: 1.8–4.5), prolonged rupture of membranes &gt;12 h (OR: 2.8, 95% CI: 1.9–4.1), male sex (OR: 1.2, 95% CI: 1.1–1.4), intrapartum fever (OR: 2.4, 95% CI: 1.5–3.7), and history of urinary tract infection in the mother (OR: 2.7, 95% CI: 1.4–5.2) are factors associated with neonatal sepsis. Rural residence (OR: 2.3, 95% CI: 1.01–10.9), parity (OR: 0.5, 95% CI: 0.3–0.7), prolonged labor (OR: 3.4, 95% CI: 1.6–6.9), and multiple digital vaginal examinations (OR: 4.4, 95% CI: 1.3–14.3) were significantly associated with maternal sepsis.ConclusionThe prevalence of maternal and neonatal sepsis was high in sub-Saharan Africa. Multiple factors associated with neonatal and maternal sepsis were identified. These factors could help in the prevention and development of strategies to combat maternal and neonatal sepsis. Given the high risk of bias and high heterogeneity, further high-quality research is needed in the sub-Saharan African context, including a meta-analysis of individual data.Systematic review registration: PROSPERO (ID: CRD42022382050).
Comprehensiveness of online sources for patient education on otosclerosis
Authors: Cırık Ahmet Adnan , Yiğit Yeşim Esen , Tekin Ahmet Mahmut , Duymaz Yaşar Kemal , Şahin Şamil , Erkmen Burak , Topsakal Vedat 
Published: January 2024

PurposeThis study aimed to assess the readability indices of websites including educational materials on otosclerosis.MethodsWe performed a Google search on 19 April 2023 using the term “otosclerosis.” The first 50 hits were collected and analyzed. The websites were categorized into two groups: websites for health professionals and general websites for patients. Readability indices were calculated using the website https://www.webfx.com/tools/read-able/.ResultsA total of 33 websites were eligible and analyzed (20 health professional-oriented and 13 patient-oriented websites). When patient-oriented websites and health professional-oriented websites were individually analyzed, mean Flesch Reading Ease scores were found to be 52.16 ± 14.34 and 46.62 ± 10.07, respectively. There was no significant difference between the two groups upon statistical analysis.ConclusionCurrent patient educational material available online related to otosclerosis is written beyond the recommended sixth-grade reading level. The quality of good websites is worthless to the patients if they cannot comprehend the text.
Business Strategy and Competitive Advantage of Companies
Authors: Tukirin Tukirin 
Published: January 2024

The purpose of this paper is to identify and describe the role of culture and strategic choices in achieving competitive advantage for companies. The research methodology uses a systematic literature review that includes international journals that discuss strategic management. From several journals, an analysis was carried out and a common thread was drawn to get a scientific understanding related to the topic and title of this article. The results of the study indicate that in doing business across countries, it is very necessary to understand the right culture so that the company's presence can be accepted by the community. Companies can achieve competitive advantage by applying the right strategy to the right industry structure or by combining strategies and resources. Companies can implement strategies as needed and do not have to imitate all strategies, for example, companies in Japan only apply Porter's two strategies, the most of which are overall cost advantages, while the second is differentiation, while others use the original Japanese strategy.

Keywords: Business strategy, competitive advantage, and company
The Influence Of Corporate Culture And Internal Control Systems On The Prevention Of Merchandise Fraud
Authors: Rahmawati Laela , Pradata Bramastyasa Gilang 
Published: January 2024

Fraud is a problem that can hinder the achievement of company goals and is usually carried out by individuals who have experience in their field which occurs due to opportunities and conflicts of interest. Therefore, companies need tools that can help in terms of corporate culture or the values that underlie the company's identity, such as regulatory attitudes that employees in the company must have and internal controls such as internal audits. The purpose of this research is to test and find out how much influence company culture and internal control have on preventing goods fraud. Data collection was carried out through distributing questionnaires whose validity and reliability had been tested. For the results of this research, the influence of company culture (X1 ) on preventing goods fraud (Y) has a significant effect. This shows that the better the corporate culture in a company, the better the prevention of goods fraud. For the results, the influence of internal control (X 2 ) on the prevention of goods fraud (Y) has a significant effect. This shows that the better the internal control carried out in the company, the better the prevention of goods fraud .

Keywords: Company Culture, Control System, Merchandise Fraud
PENGARUH LATIHAN BERBEBAN MENINGKAT SECARA LINEAR DAN NONLINEAR TERHADAP KEKUATAN OTOT TUNGKAI
Authors: Burahim Sabran A. , Duhe Edy Dharma Putra , Hidayat Syarif , Suardika I Kadek 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui perbedaan pengaruh latihan berbeban meningkat secara linear dan latihan berbeban meningkat secara nonlinear terhadap kekuatan otot tungkai pada siswa putera kelas X SMA Negeri 1 Tapa. Adapun subjek dalam penelitian adalah siswa putera kelas X SMA Negeri 1 Tapa dengan jumlah siswa 20 orang putera. Metode yang digunakan dalam penelitian ini adalah penelitian eksprimen dengan desain two group pretest and posttest design. Hasil penelitian menunjukkan bahwa; (1) Ada pengaruh latihan berbeban dengan beban meningkat secara linear terhadap kekuatan otot tungkai dengan dibuktikan t hitung 3,855 lebih besar t tabel 1,833 (2) Ada pengaruh latihan berbeban dengan beban meningkat secara nonlinear terhadap kekuatan otot tungkai dengan dibuktikan t hitung 4,415 lebih besar t tabel 1,833 (3) terdapat perbedaan pengaruh latihan berbeban dengan beban meningkat secara linear dan meningkat secara nonlinear terhadap kekuatan otot tungkai dengan dibuktikan t hitung 4,553 lebih besar t tabel 1,73. Disimpulkan bahwa latihan berbeban meningkat secara linear dan latihan berbeban dengan beban meningkat secara non linier dapat meningkatkan kekuatan otot tungkai, akan tetapi latihan berbeban meningkat secara linear memberikan peningkatan yang lebih baik.
Exploring X-Ray Properties of Low-metallicity Dwarf Galaxies
Authors: Cann Jenna M. , Weaver Kimberly A. , Pfeifle Ryan W. , Secrest Nathan J. , Satyapal Shobita , Gliozzi Mario 
Published: January 2024

Abstract
One of the primary outstanding questions in extragalactic astronomy is the formation and early evolution of the supermassive black holes that are seen in nearly every massive galaxy. Low-metallicity dwarf galaxies may offer the most representative local analogs to pristine early galaxies, making them a vital tool in probing black hole seed models through the study of the intermediate-mass black holes (IMBHs) possibly hosted therein; though these dwarf galaxies, and the IMBHs they may host, are typically not as well-studied in this context as their higher-metallicity and higher-mass counterparts. In this paper, we explore the X-ray properties of a sample of 37 low-metallicity dwarf galaxies using archival XMM observations, and we compare the properties of this population against a representative sample of higher-metallicity counterparts. We report the detection of 10 sources with 0.3–10 keV luminosity in excess of 1040 erg s−1 within the low-metallicity sample, which we highlight for followup as potential IMBH candidates. Finally, we discuss the differing multiwavelength scaling relations (e.g., L
X–L
W2, L
X–star formation rate) between the two galaxy populations, as well as the sample’s L
X as a function of metallicity.