bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PENGETAHUAN DAN SIKAP PASIEN TUBERKULOSIS PARU TERHADAP PERILAKU PENCEGAHAN TUBERKULOSIS DI WILAYAH KERJA PUSKESMAS KEDATON BANDAR LAMPUNG
Authors: Susanto Febi , Rafie Rakhmi , Pratama Sandhy Arya , Farich Achmad 
Published: November 2023

Abstrak: Hubungan Pengetahuan dan Sikap Pasien Tuberkulosis Paru Terhadap Perilaku Pencegahan Tuberkulosis Di Wilayah Kerja Puskesmas Kedaton Bandar Lampung. Tuberkulosis (TB) merupakan penyakit infeksi kronis yang mudah menular melalui droplet. Faktor pengetahuan dan sikap mempunyai pengaruh besar terhadap perilaku pencegahan tuberkulosis di masyarakat dan berperan penting didalam menentukan keberhasilan suatu program pengendalian penyakit menular khususnya tuberkulosis. Mengetahui hubungan pengetahuan pasien mengenai pencegahan tuberkulosis paru dan sikap terhadap perilaku pencegahan tuberkulosis di Wilayah Kerja Puskesmas Kedaton Bandar Lampung tahun 2023. Menggunakan analitik kuantitatif dengan rancangan penelitian ini menggunakan rancangan cross sectional. Berdasdarkan kriteria inklusi dan eksklusi didapatkan sampel sebanyak 105 orang. Analisa data menggunakan uji Chi Square. Diketahui distribusi frekuensi pengetahuan responden sebagian besar adalah baik sebanyak 73 orang (69.5%), Sikap sebagian besar adalah positif sebanyak 65 orang (61.9%) dan perilaku sebagian besar adalah baik sebanyak 58 orang (55.2%). Terdapat hubungan antara pengetahuan (p-value=0,002) dan sikap (p-value=0.024) terhadap perilaku pencegahan tuberkulosis di Wilayah Kerja Puskesmas Kedaton Bandar Lampung tahun 2023. Dalam menentukan keberhasilan perilaku pencegahan penyakit TB dipengaruhi oleh beberapa faktor antara lain pengetahuan dan sikap individu.
The attitude of preventing opportunistic infections among PLHIV/AIDS attending non-governmental organization (Kuldesak) Depok City, Indonesia
Authors: Hadi Talitha El Zhafira , Helda Helda 
Published: November 2023

Background: The number of people living with HIV and AIDS (PLWHA) is increasing and it has become a pandemic in various parts of the world. However, there are still limited AIDS countermeasures in preventing death, one of which is by reducing opportunistic infections.Purpose: To determine the factors associated with the attitude of preventing opportunistic infections among PLHIV/AIDS attending non-governmental organization (Kuldesak) Depok City, IndonesiaMethod: An analytic research with a cross-sectional research design which aims to determine the relationship between the independent variables and the dependent variable. The number of samples in this study were 71 PLHIV attending non-governmental organization “Kumpulan Dengan Segala Aksi Kemanusiaan” (Kuldesak) Peer Support Group (PSG) Depok City, Indonesia. Samples were taken using a non-random sampling technique with purposive sampling.Results: Obtained that three variables influenced the attitudes to prevent opportunistic infection in PLWHA, namely perceived susceptibility (AOR = 4,98; 95% CI = 1,459-17,029), perceived severity (AOR = 4,04; 95% CI = 1,161-14,079) and perceived benefit (AOR = 7,13; 95% CI = 1,846-27,601).Conclusion: Almost half of all respondents in the Kuldesak Peer Support Group (PSG) Depok City have a low attitudes to prevent opportunistic infection. Perceived benefit was the most dominant predictor in determining attitudes to prevent opportunistic infection.Suggestion: In order to further develop this research and provide education so that the attitude of OI preventing, especially in PLWHA, is better than before.
The effect of coconut water on alleviating menstrual pain (dysmenorrhea) in teenage women
Authors: Febriani Luky , Wahyuni Elly , Mizawati Afrina 
Published: November 2023

Background: World Health Organization (WHO) in 2018 stated that the number of dysmenorrhea in the world is very large, on average more than 50% of women in each country experience dysmenorrhea. In the United States, it is estimated that almost 90% of women experience dysmenorrhea and 10-15% of them experience dysmenorrhea severe, which causes them to be unable to carry out any activities. Purpose: To find out "The effect of green coconut water on reducing menstrual pain (dysmenorrhea) in adolescent girls at Junior High School 02 Bengkulu City in 2021.Method: This research was conducted using the method Quasi Experiment with a plan one grup pretest posttest design. Random sampling technique total sampling as many as 28 young women experienced it dysmenorrhea currently. Data analysis consists of univariate, bivariate and multivariate analysis. The sample tests used were Wilcoxon, Mann Whitney and Binary Logistic Regression tests.Results: The results of this study showed that the average pain dysmenorrhea before and after had given coconut water was 5.18 and the average pain after had given coconut water was 2.64. The statistical test results obtained p-value= 0.000, with a mean difference of 2.54 which shows that there is an influence on giving coconut water to young women at Junior High School 02 Bengkulu City in 2021.Conclusion: It is hoped that the school at Junior High School 02 Bengkulu City can optimize School's Health Clinic program services such as increasing the role of officers to implement canteens or school cooperatives to be able to provide coconut water which has the effect of reducing pain dysmenorrhea in teenage girls.
Trastornos del sueño asociados al trabajo nocturno del personal de salud de la Clínica Praxxel - Cuenca
Authors: Parra Siguenza Diana Carolina , Baculima Suarez José Antonio , Mariño Andrade Henry Geovanny 
Published: November 2023

El trabajo nocturno representa una doble alteración como es trabajar de noche y dormir de día. Los profesionales de la salud, son uno de los grupos afectados por el trabajo en turnos nocturnos, aspecto que puede tener repercusión en la calidad asistencial, el objetivo del presente trabajo busca evaluar los trastornos del sueño asociados al trabajo nocturno en 20 profesionales de salud de la clínica Praxxel en el periodo 2021-2022. Para lo cual se utiliza la investigación analítica, con universo conocido que correspondió con la muestra y lo constituyeron 20 trabajadores del personal de salud de la Clínica Praxxel de la ciudad de Cuenca. A quienes se les aplicó la escala Epworth, y un cuestionario para recolectar información adicional, los resultados demuestran que el 75% del personal tienen trastornos del sueño ligero y solo el 20% de los profesionales de la salud de la Clínica Praxxel de la ciudad de Cuenca entrevistados, mostró afectación del sueño moderada o grave, en conclusión las condiciones laborales fueron buenas según refieren la mayoría de los entrevistados, aunque las dificultades en las condiciones laborales de algunos participantes hacen que presenten trastornos del sueño. Área de estudio general: Medicina. Área de estudio específica: Medicina Ocupacional. Tipo de estudio: Artículos originales / Original articles
The Effect of Atorvastatin Plus Ezetimibe Therapy Versus Atorvastatin Monotherapy on Clinical Outcome in Acute ST-Segment Elevation Myocardial Infaction(STEMI)
Authors: Abdul Mukid Md , Shahabuddin Md , Tazin Farzana , Suhail Alam Md , Roy Chowdhury Partha Sarathi 
Published: November 2023

Introduction: An acute ST-elevation myocardial infarction (STEMI) is an event in which transmural myocardial ischemia results in myocardial injury or necrosis. The current 2018 clinical definition of myocardial infarction (MI) requires the confirmation of the myocardial ischemic injury with abnormal cardiac biomarkers. Acute coronary syndrome is the leading cause of death in the world and this is a consequence of unstable plaque due to dyslipidemia, reviewing with elevated LDL cholesterol. Reduction in LDL-c repeated clinical outcomes in patients with the acute coronary syndrome.
Objective: To assess the effect of atorvastatin plus ezetimibe therapy versus atorvastatin monotherapy on clinical outcome in acute ST-Segment Elevation Myocardial Infaction(STEMI).
Materials and Methods: A cross-sectional study was performed at dept. of Cardiology, Parkview Medical College, Sylhet, Bangladesh from June to December 2022. A total of 50 patients were evaluated in the study, including 42 patients with acute coronary syndrome with LDL-c levels≥70mg/dL at Can Tho Central General Hospital, we divided randomly into 2 groups: group A: control LDL-c by atorvastatin 40mg and ezetimibe 10mg; group B: control LDL-c by atorvastatin 40mg monotherapy. Then we compared the effect of control LDL-c between two groups after 10 follow-up days.
Results: 50 patients with acute coronary syndrome: 60.0% male and 40.0% female, the average age was 66.03 ± 12.06 years, 82.0% LDL- c levels ≥7 mg/dL. After 10 days of treatment, the target LDL-c concentration in the group treated with atorvastatin 40mg+ ezetimibe 10mg was 48.1%, in the group treated with atorvastatin 40mg was 29.9% (p<0.05).
Conclusions: LDL-c ratio reaches the target in the treatment group by atorvastatin 40mg + ezetimibe 10mg was 48.1% in the treatment group with atorvastatin 40 mg was 29.9% (p<0.05). From the results of our study, we recommend the combination therapy of atorvastatin and ezetimibe control LDL-c in patients with acute coronary syndrome better than atorvastatin monotherapy, thus physicians to treat patients with the acute coronary syndrome should combine early atorvastatin with ezetimibe since hospitalization.
Medicine Today 2023 Vol. 35(2): 99-104
Comparative Study on Serum Calcium in Pre-Eclampsia and Non Pregnant Women
Authors: Lal Roy Heera , Nargis Susmita 
Published: November 2023

Introduction: There are many Hypertensive disorders in pregnancy like preeclampsia, eclampsia etc. Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Some studies have implicated that low serum calcium levels may have a role in pre-eclampsia but other studies failed to find relation between low levels of these trace elements and pre-eclampsia.
Objectives:​To evaluate serum calcium in pre-eclampsia & non pregnant women.
Materials and Methods: ​This cross sectional study was carried out in among 31 pre-eclampsia patients, aged 20 to 40 years, and gestational age ranges from 20 to40 weeks and 31 age matched normotensive non-pregnant women having no proteinuria. Serum calcium was measured by Colorimetric method.
Results:The mean serum calcium level was 5.91 (±2.12) mg/dl in pre–eclampsia and was 5.72 (±2.46) mg/dl in normal women.
Conclusion The mean serum calcium level did not differ significantly between the subjects of pre–eclampsia and normal women (t=0; p<.05). The means of both data sets are equal so we can conclude that there is no significant difference between them.
Medicine Today 2023 Vol.35(2): 121-123
Impacto da orientação farmacoterapêutica na adesão ao tratamento com psicofármacos – Revisão integrativa
Authors: Araújo Winie Fernanda Ribeiro de , Fonseca Liriani Rodrigues da , Ribeiro Wera Lucia Siqueira , Sant’Anna Carla 
Published: November 2023

Atualmente tem ocorrido aumento significativo dos diagnósticos de transtornos mentais, os quais causam grande impacto em termos de morbidade, prejuízos na funcionalidade e diminuição da qualidade de vida de seus portadores, pois aproximadamente 90% dos problemas de saúde mental apresentam manifestações de depressão, ansiedade, insônia, fadiga, irritabilidade, disfunção de memória e de concentração. O objetivo deste trabalho foi analisar as dificuldades vividas pelos pacientes durante o tratamento de transtornos mentais e a importância da assistência farmacêutica para a boa adesão ao tratamento farmacológico dos mesmos. Foi realizada uma revisão integrativa de literatura sobre problemas durante o tratamento com psicofármacos e importância da orientação farmacoterapêutica para a boa adesão do tratamento. A análise e interpretação dos resultados obtidos foi realizada por meio da interpretação e da inferência e consistiu na apresentação dos estudos selecionados e explanação das categorias definidas para análise. Foram identificados 42 artigos na pesquisa nas plataformas eletrônicas. Foram excluídos 6 pela data de publicação, 4 pelo idioma diferente de português e inglês e 5 por texto incompleto ou duplicata e que não abordavam o tema, resultando em 27 artigos para avaliação do resumo. Nesta fase, foram excluídos 7 artigos que não tratavam da questão de pesquisa, 20 estudos para leitura do texto selecionado completo e incluídos nesta revisão. O estudo permitiu concluir a importância do trabalho do profissional farmacêutico na orientação farmacoterapêutica em saúde mental.
Resinas compostas monocromáticas: Uma abordagem em caso clínico
Authors: Silva Thalia Santos , Oliveira Mirelle Domingues Ferreira de , Almeida Ádila Santos , Rodrigues Ítalo Samuel Gonçalves , Santana Tauan Rosa de 
Published: November 2023

Com o avanço da estética faz-se necessário a evolução constante dos materiais odontológicos em busca do mimetismo natural. Com isso, as resinas monocromáticas surgiram trazendo o famoso efeito camaleão capaz de se adaptar às cores das paredes circundantes dos dentes trazendo um material restaurador agradavelmente estético e de fácil manuseio, dispensando a seleção de cor dos dentes e o uso de diferentes resinas diminuindo assim o tempo da cadeira odontológica. O objetivo desse estudo foi avaliar a eficácia das resinas compostas monocromáticas, demonstrando seu uso e eficácia no consultório odontológico por meio de um caso clínico. Paciente MJMS, 70 anos, compareceu à clínica odontológica da Universidade Tiradentes (UNIT) queixando-se de sensibilidade dentária devido à fratura de restauração cervical do dente 26. O tratamento escolhido foi a restauração com compósito monocromático da unidade, que atendeu bem a necessidade clínica, otimizando o tempo de atendimento. A resina composta monocromática é um ótimo material disponível no mercado por causa da sua capacidade de mimetizar os dentes naturais, alcançando uma estética agradável, associada à praticidade de um menor tempo clínico.
Language acquisition in Autism Spectrum Disorder: Strategies for early diagnosis and intervention – A review of literature
Authors: Lima Micael Porto Portela , Carneiro Marcela Olímpio Vasconcelos , Mendonça Éden Moura , Oliveira Clara Beatrice Gonçalves Cordeiro de , Benevides Sílvia Barbosa , Forte Brenda Larissa da Rocha , Campos Thaís Lopes , Amarante Michele Montier Freire do , Andrade Neto José Araujo de 
Published: November 2023

Autism Spectrum Disorder (ASD) is characterized as a neurodevelopmental disorder, with deficits in communication and social interaction with a defined diagnostic criteria. Although the main diagnosis is made by the pediatric neurologist and/or the psychiatrist, the clinician ability to refer children with a suspected condition, based on language differences to their neurotypical peers, is crucial for shortening the diagnosis time. Because it is a neurodevelopmental condition, the earlier the interventions, the better the responses and prognosis in development. In this literature review, we aim at an updated discussion about the role of ASD on the child brain, the language development differences in neurotypical and ASD children, the emerging early diagnosis technologies, and the early intervention therapies available for verbal and non-verbal ASD children’s, as well as adults, with a final focus on music therapy.
Seribu islands in the megacities of Jakarta on the frontlines of the climate crisis
Authors: Setiawati Martiwi Diah , Chatterjee Uday , Djamil Yudha Setiawan , Alifatri La Ode , Nandika Muhammad Rizki , Rachman Herlambang Aulia , Supriyadi Indarto Happy , Hanifa Nuraini Rahma , Muslim Aidy M. , Eguchi Tsuyoshi , Prayudha Bayu , Oktaviani Aulia , Adi Novi Susetyo , Renyaan Jeverson , Sulha Siti , Wouthuyzen Sam , Pal Subodh Chandra , Islam Abu Reza Md. Towfiqul , Alam Edris , Islam Md Kamrul 
Published: November 2023

Jakarta, the biggest city in Indonesia, has one district that consists of hundreds of islands that face severe climate hazards called the Seribu Islands complex. This study explores the evidence of local climate trends, the potential impact, and its policy intervention on Seribu Islands, which are classified as small island states and widely recognized as being especially at risk from climate change, threatening their economic and social growth. Long-term in-situ climate data, satellite data, interviews with local stakeholders, and literature reviews were utilized to conduct an exploratory descriptive analysis. The result revealed that Seribu Island experienced a 2.2°C increase in minimum temperature from 1980 until 2021, 3.5-fold of the frequency of extreme temperature and precipitation, 4.17 mm/year of sea level rise, and 10.8 ha land expansion in the densest island. Moreover, about 67% of the inhabitant’s islands were occupied by built-up areas that cover more than 50% of the region. Further, under the worst-case SLR scenario, about 58.4% of the area will be affected, and about 29 islands will disappear. This evidence was also reinforced by every single local respondent’s viewpoint who felt that climate change is occurring in the region. Even though the region faces a severe threat of climate change, the issue of climate change adaptation has not been mainstreamed yet into their local policy. Therefore, the urgency of a real-time climate ground station, a real-time early warning system, and establishing a Regional Disaster Management Agency (BPBD) at the district level have yet to be addressed. Furthermore, the knowledge gained from such case studies is outlined, along with some scientific evidence that may assist small island states in better fostering the opportunities provided by climate change adaptation.
Human adipose tissue as a major reservoir of cytomegalovirus-reactive T cells
Authors: Redruello-Romero Anaïs , Benitez-Cantos Maria S. , Lopez-Perez David , García-Rubio Jesús , Tamayo Francisco , Pérez-Bartivas Daniel , Moreno-SanJuan Sara , Ruiz-Palmero Isabel , Puentes-Pardo Jose D. , Vilchez Jose R. , López-Nevot Miguel Á. , García Federico , Cano Carlos , León Josefa , Carazo Ángel 
Published: November 2023

IntroductionCytomegalovirus (CMV) is a common herpesvirus with a high prevalence worldwide. After the acute infection phase, CMV can remain latent in several tissues. CD8 T cells in the lungs and salivary glands mainly control its reactivation control. White adipose tissue (WAT) contains a significant population of memory T cells reactive to viral antigens, but CMV specificity has mainly been studied in mouse WAT. Therefore, we obtained blood, omental WAT (oWAT), subcutaneous WAT (sWAT), and liver samples from 11 obese donors to characterize the human WAT adaptive immune landscape from a phenotypic and immune receptor specificity perspective.MethodsWe performed high-throughput sequencing of the T cell receptor (TCR) locus to analyze tissue and blood TCR repertoires of the 11 donors. The presence of TCRs specific to CMV epitopes was tested through ELISpot assays. Moreover, phenotypic characterization of T cells was carried out through flow cytometry.ResultsHigh-throughput sequencing analyses revealed that tissue TCR repertoires in oWAT, sWAT, and liver samples were less diverse and dominated by hyperexpanded clones when compared to blood samples. Additionally, we predicted the presence of TCRs specific to viral epitopes, particularly from CMV, which was confirmed by ELISpot assays. Remarkably, we found that oWAT has a higher proportion of CMV-reactive T cells than blood or sWAT. Finally, flow cytometry analyses indicated that most WAT-infiltrated lymphocytes were tissue-resident effector memory CD8 T cells.DiscussionOverall, these findings postulate human oWAT as a major reservoir of CMV-specific T cells, presumably for latent viral reactivation control. This study enhances our understanding of the adaptive immune response in human WAT and highlights its potential role in antiviral defense.
Nitrogen addition strengthens the stabilizing effect of biodiversity on productivity by increasing plant trait diversity and species asynchrony in the artificial grassland communities
Authors: Suonan Ji , Lu Xuwei , Li Xiaona , Hautier Yann , Wang Chao 
Published: November 2023

Background and aimsNitrogen (N) enrichment usually weakens the stabilizing effect of biodiversity on productivity. However, previous studies focused on plant species richness and thus largely ignored the potential contributions of plant functional traits to stability, even though evidence is increasing that functional traits are stronger predictors than species richness of ecosystem functions.MethodsWe conducted a common garden experiment manipulating plant species richness and N addition levels to quantify effects of N addition on relations between species richness and functional trait identity and diversity underpinning the ‘fast–slow’ economics spectrum and community stability.ResultsNitrogen addition had a minor effect on community stability but increased the positive effects of species richness on community stability. Increasing community stability was found in the species-rich communities dominated by fast species due to substantially increasing temporal mean productivity relative to its standard deviation. Furthermore, enhancement in ‘fast–slow’ functional diversity in species-rich communities dominated by fast species under N addition increased species asynchrony, resulting in a robust biodiversity–stability relationship under N addition the artificial grassland communities.ConclusionThe findings demonstrate mechanistic links between plant species richness, ‘fast–slow’ functional traits, and community stability under N addition, suggesting that dynamics of biodiversity–stability relations under global changes are the results of species-specific responses of ‘fast–slow’ traits on the plant economics spectrum.