bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low redundancy among caddisflies sharing a mid‐mountain stream
Authors: Pacini Nic , Travagliante Emanuele , Methu Stephen Wanjiku , Gumiero Bruna , Brilli Mauro , Harper David Malcolm 
Published: October 2023

AbstractIn fast‐flowing streams, caddisfly larvae are responsible for processes that collectively determine the efficiency with which the detritivore community is able to decompose autochthonous and allochthonous detritus. This ecosystem function ensures high water quality and represents a precious service for resident rural communities. The analysis of δ13C and δ15N in eight caddisfly taxa from a mid‐mountain stream evidenced a remarkable complementarity in their feeding preferences. An aquatic moth mimicking the caddis mode of life was also included in the survey and its feeding niche appeared to be in between the one of caddis taxa. Moderate niche overlap was interpreted in terms of low functional redundancy, implying that in case of a reduction in diversity, no taxon could be a perfect substitute for another, with a loss of functional efficiency. Low redundancy could be caused by niche segregation due to avoidance of competition/interference between taxa. The broad range of δ13C and δ15N described in this study warns against attributing single δ13C and δ15N to Trichoptera as a group, or even to single families. These results contribute to the still poorly known distribution of East African caddisflies and to the characterisation of feeding preferences of Afrotropical trichopteran larvae.
Bibliometric analysis with reference publication year spectroscopy showed how key programmes drove developmental care in newborn infants
Authors: Smith Meghan , Marx Werner , Anand Kanwaljeet S. , Haunschild Robin , Bornmann Lutz , Sizun Jacques , Roue Jean‐Michel 
Published: October 2023

AbstractAimWe investigated the historical origins of developmental care for newborn infants using Reference Publication Year Spectroscopy (RPYS), an innovative method of bibliometric analysis.MethodsA Web of Science search query that combined infant and intervention‐related synonyms was performed on 2 February 2022. RPYS analysis was performed on this dataset to identify the most referenced historical publications for developmental care in newborn infants. Median deviation analysis identified the peak publication years, including the most cited historical references. Landmark publications were defined as those belonging to the top 10% of the most frequently referenced publications for at least 20 years.ResultsThe RPYS peaks showed an early phase (1936–1986), during which infant development was studied and analysed, leading to a conceptualisation of developmental care for newborn infants. The following years (1987–2020), showed an explosion of interest in developmental care and highlighted two main programmes. The Neonatal Individualized Developmental Care Assessment Program (NIDCAP) and the Infant Health and Development Program (IHDP) inspired numerous publications during those years, which strove to demonstrate evidence of their clinical benefits.ConclusionDevelopmental care has become increasingly important, thanks to the implementation of NIDCAP and IHDP.
Tracing origin and history of Virgin and Child in Majesty, the oldest wooden polychrome statuette in the Czech Republic
Authors: Hradilová Janka , Hradil David , Širillová Zuzana , Švarcová Silvie 
Published: October 2023

AbstractA wooden polychrome statuette of Virgin and Child in Majesty, currently in the Museum Montanelli in Prague, is actually a torso. It was created in the 11th or 12th century at the latest, being the oldest wooden polychrome statuette in the Czech Republic. Current research combining advanced imaging and micro‐analytical methods substantially contributed to the determination of its regional origin and detection and dating of later interventions. Identified pigments, including azurite, vivianite and smalt, together with changes in gilding technology, were found to be essential in tracing the story of the statuette over time.
The intersection of traumatic childbirth and obstetric racism: A qualitative study
Authors: Dmowska Amelia , Fielding‐Singh Priya , Halpern Jodi , Prata Ndola 
Published: October 2023

AbstractBackgroundTraumatic childbirth experiences are common in the United States – affecting a third to a fourth of mothers – with significant negative impacts on maternal health. Yet most research on traumatic childbirth focuses on white mothers’ experiences. Drawing on a racially and ethnically diverse sample of mothers who experienced traumatic childbirth, this exploratory qualitative study examined Black, Latina, and Asian mothers' traumatic birth experiences and the role of obstetric racism in shaping these experiences.MethodsIn‐depth, semi‐structured interviews were conducted in 2019–2020 with 30 mothers who identified as women of color (37% Black, 40% Latina, and 23% Asian) who gave birth in the US and self‐identified as having experienced a traumatic childbirth. Data were analyzed using qualitative content analysis.ResultsMothers reported obstetric racism as core to their traumatic birth experiences. This racism manifested through practitioners' use of gendered and racialized stereotypes, denying and delegitimizing mothers' needs. Mothers shared key consequences of the obstetric racism they experienced, including postpartum anxiety and depression, increased medical mistrust, and decreased desire for future children.ConclusionsMothers' reports suggest that obstetric racism played a role in their traumatic birth experiences. Particularly, practitioners' deployment of gendered and racialized stereotypes influenced mothers' treatment during birth. These findings point to opportunities to address obstetric racism during childbirth and improve patients' experiences through enhancing their agency and empowerment. The findings, in addition, highlight the need for increased practitioner training in anti‐racist practice and cultural humility.
Parity, mode of birth, and long‐term gynecological health: A follow‐up study of parous and nonparous women in the Australian Longitudinal Study on Women's Health cohort
Authors: Nohr Ellen A. , Taastrøm Katja A. , Kjeldsen Anne Cathrine M. , Wu Chunsen , Pedersen Frank Henning , Brown Wendy J. , Davis Deborah L. 
Published: October 2023

AbstractBackgroundAlthough gynecological health issues are common and cause considerable distress, little is known about their causes. We examined how birth history is associated with urinary incontinence (UI), severe period pain, heavy periods, and endometriosis.MethodsWe studied 7700 women in the Australian Longitudinal Study on Women's Health with an average follow‐up of 10.9 years after their last birth. Surveys every third year provided information about birth history and gynecological health. Logistic regression was used to estimate how parity, mode of birth, and vaginal tears were associated with gynecological health issues. Presented results are adjusted odds ratios (OR) with 95% confidence intervals.ResultsUI was reported by 16%, heavy periods by 31%, severe period pain by 28%, and endometriosis by 4%. Compared with women with two children, nonparous women had less UI (OR 0.35 [0.26–0.47]) but tended to have more endometriosis (OR 1.70 [0.97–2.96]). Also, women with only one child had less UI (OR 0.77 [0.61–0.98]), but more severe period pain (OR 1.24 [1.01–1.51]). Women with 4+ children had more heavy periods (OR 1.42 [1.07–1.88]). Compared with women with vaginal birth(s) only, women with only cesarean sections or vaginal birth after cesarean section had less UI (ORs 0.44 [0.34–0.58] and 0.55 [0.40–0.76]), but more endometriosis (ORs 1.91 [1.16–3.16] and 2.31 [1.25–4.28]) and heavy periods (ORs 1.21 [1.00–1.46] and 1.35 [1.06–1.72]). Vaginal tear(s) did not increase UI after accounting for parity and birth mode.ConclusionWhile women with vaginal childbirth(s) reported more urinary incontinence, they had less menstrual complaints and endometriosis.
Improved outcomes of large B‐cell lymphoma patients treated with CD19 CAR T in the UK over time
Authors: Boyle S. , Roddie C. , O'Reilly M. , Menne T. , Norman J. , Gibb A. , Lugthart S. , Chaganti S. , Gonzalez Arias C. , Jones C. , Latif A. , Uttenthal B. J. , Seymour F. , Osborne W. , Springell D. , Hardefeldt P. , Yallop D. , Thoulouli E. , Bloor A. , Besley C. , Mathew A. , Burns D. , Cwynarski K. , Sanderson R. , Kuhnl A. 
Published: October 2023

SummaryThe success of CD19 Chimeric antigen receptor (CAR) T‐cell therapy in large B‐cell lymphoma (LBCL) has been partially offset by toxicity and logistical challenges, which off‐the‐shelf agents like CD20xCD3 bispecific antibodies might potentially overcome. However, when using CAR T outcomes as the ʽstandard‐of‐care comparator̕ for relapsed/refractory (r/r) LBCL, a potential learning curve with implementing a novel, complex therapy like CAR T needs to be considered. To address this, we analysed 726 UK patients intended to be treated with CD19 CAR T for r/r LBCL and compared outcomes between the first year of the national CAR T programme (Era 1; 2019) and the more recent treatment era (Era 2; 2020–2022). We identified significant improvements for Era 2 versus Era 1 in dropout rate (17% vs. 27%, p = 0.001), progression‐free survival (1‐year PFS 50% vs. 32%, p < 0.001) and overall survival (1‐year OS 60% vs. 40%, p < 0.001). We also observed increased use of bridging therapy, improvement in bridging outcomes, more tocilizumab/corticosteroid use, reduced high‐grade cytokine release syndrome (4% vs. 9%, p = 0.01) and intensive care unit admissions (20% vs. 32%, p = 0.001). Our results demonstrate significant improvement in CAR T outcomes over time, highlighting the importance of using up‐to‐date clinical data when comparing CAR T against new treatment options for r/r LBCL.
Astrocytic phagocytosis of myelin debris and reactive characteristics in vivo and in vitro
Authors: Li Xiaohui , Ding Zhibin , Liu Kexin , Wang Qing , Song Lijuan , Chai Zhi , Yu Jiezhong , Ma Dong , Xiao Baoguo , Ma Cungen 
Published: October 2023

AbstractBackground InformationPersistent myelin debris can inhibit axonal regeneration, thereby hindering remyelination. Effective removal of myelin debris is essential to eliminate the interference of myelin debris in oligodendrocyte progenitor cell (OPC) activation, recruitment to demyelinating sites and/or differentiation into mature oligodendrocytes (OLs). In addition to microglia, it has been reported that astrocytic phagocytosis of myelin debris is a feature of early demyelination.ResultsIn the present study, astrocytes effectively phagocytized myelin debris in vitro and in vivo. On the 5th day after injecting myelin debris into the brain, astrocytes were enriched in the area injected with myelin debris compared with microglia, and their ability to engulf myelin debris was stronger than that of microglia. When exposed to myelin debris, astrocytes phagocytizing myelin debris triggered self‐apoptosis, accompanied by the activation of NF‐κB, down‐regulation of Nrf2, and the increase of ciliary neurotrophic factor (CNTF) and basic fibroblast growth factor (bFGF). However, the activation of astrocytic NF‐κB did not influence the inflammatory cytokines IL‐1β, IL‐6, and TNF‐α, and the anti‐inflammatory factor IL‐10. The proliferation of astrocytes and mobilization of OPCs in the subventricular zone were elevated on the 5th day after intracerebral injection of myelin debris.ConclusionsThe results suggested that myelin phagocytosis of astrocytes should help improve the microenvironment and promote myelin regeneration by increasing CNTF and bFGF within the central nervous system.SignificanceHowever, the molecular interaction of astrocytes acting as phagocytes remains to be further explored. Therefore, an improvement of astrocytes to phagocytize myelin debris may be a promising treatment measure to prevent demyelination and promote remyelination in MS and other diseases with prominent myelin injury.
Adding to the evidence of gene‐disease association of RAP1B and syndromic thrombocytopenia
Authors: Pardo Luba M. , Aanicai Ruxandra , Zonic Emir , Hakonen Anna H. , Zielske Susan , Bauer Peter , Bertoli‐Avella Aida M. 
Published: October 2023

AbstractSyndromic constitutive thrombocytopenia encompasses a heterogeneous group of disorders characterised by quantitative and qualitative defects of platelets while featuring other malformations. Recently, heterozygous, de novo variants in RAP1B were reported in three cases of syndromic thrombocytopenia. Here, we report two additional, unrelated individuals identified retrospectively in our data repository with heterozygous variants in RAP1B: NM_001010942.2(RAP1B):c.35G>A, p.(Gly12Glu) (de novo) and NM_001010942.2(RAP1B):c.178G>A, p.(Gly60Arg). Both individuals had thrombocytopenia, as well as congenital malformations, and neurological, behavioural, and dysmorphic features, in line with previous reports. Our data supports the causal role of monoallelic RAP1B variants that disrupt RAP1B GTPase activity in syndromic congenital thrombocytopenia.
Oligomer‐Aβ42 suppress glioma progression via potentiating phagocytosis of microglia
Authors: Lu Jie , Wang Zhenning , He Zhenqiang , Hu Yang , Duan Hao , Liu Zihao , Li Depei , Zhong Sheng , Ren Jiaoyan , Zhao Guojun , Mou Yonggao , Yao Maojin 
Published: October 2023

AbstractAimsGlioma is characterized by an immunosuppressed environment and a poor prognosis. The accumulation of Amyloid β (Aβ) leads to an active environment during the early stages of Alzheimer's disease (AD). Aβ is also present in glioma tissues; however, the biological and translational implications of Aβ in glioma are elusive.MethodsImmunohistochemical (IHC) staining, Kaplan–Meier (KM) survival analysis and Cox regression analysis on a cohort of 79 patients from our institution were performed to investigate the association between Aβ and the malignancy of glioma. Subsequently, the potential of oligomer‐Aβ42 (OAβ42) to inhibit glioma growth was investigated in vivo and in vitro. Immunofluorescence staining and phagocytosis assays were performed to evaluate the activation of microglia. Finally, RNA‐seq was utilized to identify the predominant signaling involved in this process and in vitro studies were performed to validate them.ResultsA positive correlation between Aβ and a favorable prognosis was observed in glioma. Furthermore, OAβ42 suppressed glioma growth by enhancing the phagocytic activity of microglia. Insulin‐like growth factor 1 (IGF‐1) secreted by OAβ42‐activated microglia was essential in the engulfment process.ConclusionOur study proved an anti‐glioma effect of Aβ, and microglia could serve as a cellular target for treating glioma with OAβ42.
Allogenic stem cells for Crohn's anal fistulas: Treating early improves the deep remission rate
Authors: Fathallah Nadia , Siproudhis Laurent , Akaffou Mélissa , Haouari Mohamed Amine , Landemaine Amandine , Pommaret Elise , Spindler Lucas , Brochard Charlène , Bouguen Guillaume , de Parades Vincent 
Published: October 2023

AbstractAimThe aim of this study was to evaluate the real‐life clinical and radiological efficacy of darvadstrocel injection into complex perianal fistulas in Crohn's disease. Secondary endpoints were to assess symptomatic efficacy, adverse effects and factors associated with complete combined clinical‐radiological response (deep remission).MethodsAfter marketing the product in France, all first patients treated consecutively were included. A complete clinical response was defined by a complete closure of all external openings with no discharge on pressure. A complete radiological response (MRI), evaluated at least after six months of follow‐up, was defined by a completely fibrotic sequela without abscess. A deep remission was defined as the association of a complete clinical response with a complete radiological response.ResultsA total of 43 patients were included (M/F: 22/21, median age 37 [26–45] years). The fistulas were already drained with seton(s) and were on biologic treatment. After a median follow‐up of 383 (359–505) days, 28 (65%) patients showed a clinical response (22 complete and 6 partial) and 16 (37%) achieved a deep remission. The Perineal Disease Activity Index decreased significantly after treatment: 39 (91%) patients reported symptomatic improvement in terms of discharge, pain, and induration, and 28 (65%) no longer had any perineal symptoms. No severe adverse events were reported. A short history of Crohn's disease <3 years was significantly associated with deep remission (OD 4.5 [1.0–19.1], p = 0.04).ConclusionDarvadstrocel injection resulted in a clinical response for two thirds of patients and deep remission for one third. A shorter duration of Crohn's disease was associated with deep remission.
Euthanasia in Colombia: Experience in a palliative care program and bioethical reflections
Authors: Erazo‐Munoz Marcela , Borda‐Restrepo Diana , Benavides‐Cruz Johana 
Published: October 2023

AbstractThe increased prevalence of advanced‐stage chronic diseases has augmented the need for palliative care teams. In Colombia, although the legislation promotes palliative care development, people still die without receiving management from a palliative care team. In addition, judiciary regulations regarding euthanasia have generated public confusion and ethical conflicts among members of the palliative care teams. Therefore, this study aimed to perform a bioethical reflection on the relationship between palliative care and euthanasia supported by data on euthanasia requests in a palliative care program. This reflection is based on retrospective and descriptive observational data, collected in two highly complex hospitals in Bogotá, Colombia. A total of 50 euthanasia requests were identified, of which 62% met the defined criteria, 16% did not, and 22% were not considered by the interdisciplinary committee for the right to die with dignity due to early death. All patients were treated and followed up by a palliative care team until their death. This study considered that palliative care could be a complement management for patients requesting euthanasia based on their experience by supporting the decision‐making, alleviating suffering, and providing emotional support in the last days of life.
Why are antlion larvae rare under the leaf litter? Testing the hypothesis of improper trap maintenance
Authors: Farji‐Brener Alejandro G. , Carrillo‐Fajardo Merly Yenedith , Rodríguez‐Malacara Jorge Tanit , Arroyo‐Rodríguez Víctor 
Published: October 2023

Abstract
Understanding why animals avoid some locations is needed to improve the theory of habitat selection. This is key in semi‐sedentary organisms, such as antlion larvae, because once established they rarely move, and their performance largely depends on local environmental conditions.
Antlion larvae are sit‐and‐wait predators that build conical pitfall traps in sandy soils to capture passing prey. They clean constantly their traps, expelling soil, prey carcasses and debris out of the pit to maintain their trapping success. Therefore, we propose that they avoid soils with leaf litter because leaves hinder the maintenance of their pits; a hypothesis that has not yet been tested.
We first demonstrated that antlion larvae (Myrmeleon inmaculatus) are rare from soils with leaf litter in a tropical semi‐deciduous forest in Mexico. We then experimentally tested the effect of leaf litter on pit maintenance by adding debris in 90 antlion traps, 45 of which were covered with a leaf, and 45 remained uncovered. Two hours after adding the debris, we recorded its location and quantified the variation in depth and diameter of the pits.
Larvae in uncovered traps were twice as effective at cleaning up the debris than larvae in covered traps. Furthermore, in just 2 h, covered traps were on average 21% shallower than control traps, probably because unsuccessful attempts to clean debris caused sand slides to fill the pit partially.
Leaf litter seems to hinder the proper maintenance of antlion traps, explaining at least partially, why these animals are rare under leaf litter.
Machine learning and internet of things applications in enterprise architectures: Solutions, challenges, and open issues
Authors: Rehman Zubaida , Tariq Noshina , Moqurrab Syed Atif , Yoo Joon , Srivastava Gautam 
Published: October 2023

SummaryThe rapid growth of the Internet of Things (IoT) has led to its widespread adoption in various industries, enabling enhanced productivity and efficient services. Integrating IoT systems with existing enterprise application systems has become common practice. However, this integration necessitates reevaluating and reworking current Enterprise Architecture (EA) models and Expert Systems (ES) to accommodate IoT and cloud technologies. Enterprises must adopt a multifaceted view and automate various aspects, including operations, data management, and technology infrastructure. Machine Learning (ML) is a powerful IoT and smart automation tool within EA. Despite its potential, a need for dedicated work focuses on ML applications for IoT services and systems. With IoT being a significant field, analyzing IoT‐generated data and IoT‐based networks is crucial. Many studies have explored how ML can solve specific IoT‐related challenges. These mutually reinforcing technologies allow IoT applications to leverage sensor data for ML model improvement, leading to enhanced IoT operations and practices. Furthermore, ML techniques empower IoT systems with knowledge and enable suspicious activity detection in smart systems and objects. This survey paper conducts a comprehensive study on the role of ML in IoT applications, particularly in the domains of automation and security. It provides an in‐depth analysis of the state‐of‐the‐art ML approaches within the context of IoT, highlighting their contributions, challenges, and potential applications.
Examining the two‐dimensional perceived marketplace influence and the role of financial incentives by SEM and ANN
Authors: Higueras‐Castillo Elena , Ramdhony Dineshwar , Kalinic Zoran , Liébana‐Cabanillas Francisco 
Published: October 2023

AbstractIn recent years, research on sustainable consumption has been particularly relevant, highlighting the importance of the collective over the individual to reduce pollution. This study focuses on the study of the perceived marketplace influence (PMI) concept in its organizational and consumer dimensions, together with the financial incentives that exist in the adoption of electric cars and their effect on green customer engagement. A sample of 382 potential buyers of electric vehicles was obtained. A new hybrid analytical approach was taken structural equation modelling and artificial neural network. The research found the most significant variables affecting purchase intention were financial incentives, followed by PMI Organization and finally PMI Consumer. The results of artificial neural network analysis confirmed all the findings of the structural equation modelling, although the importance of each PMI dimension is different for each technique used. The conclusions point to new business opportunities that can be exploited by companies selling this green technology.