bluuebunny/crossref_metadata_2025_split huggingface dataset:
Farklı Sinterizasyon Yöntemlerinin ve Blok Renginin Monolitik Zirkonya ile Adeziv Rezin Siman Arasındaki Bağ Dayanımına Etkisi
Authors: YEŞİLDAŞ Cansu , KANAT Burcu 
Published: December 2023

Amaç: Bu çalışmanın amacı; farklı sinterizasyon yöntemlerinin ve blok renginin monolitik zirkonya ile adeziv rezin siman arasındaki makaslama bağ dayanımı üzerindeki etkilerinin incelenmesidir.
Gereç ve Yöntemler: Kendinden renkli (InCoris TZI C A2, Sirona) (CZ) ve renksiz (InCoris TZI, Sirona) (Z) monolitik zirkonya blokları, sinterizasyon sonrası 4mm×4mm×4mm boyutlarında olacak şekilde küpler halinde kesildi (N=40). Renkli ve renksiz örnekler, konvansiyonel sinterizasyon (KS) ve hızlı sinterizasyon (HS) olmak üzere 2 alt gruba ayrıldı (n=10). Akrilik içerisinde sabitlenen örnekler kumlandıktan sonra primer uygulandı. Adeziv rezin siman (çap:2mm, yükseklik:2mm) şekillendirildi ve polimerize edildi. Makaslama bağ dayanım (SBS) testinin (Bisco, ABD, 0.5 mm/dk) uygulanması ile elde edilen verilerin istatistiksel analizi (SPSS 26, 2-yönlü ANOVA, bağımsız t-testi) gerçekleştirildi (p=0.05). Kırık tipleri sınıflandırıldı.
Bulgular: En yüksek SBS değeri KS-Z (25.13±8.47) grubunda, en düşük SBS değeri ise HS-Z (14.89±7.08) grubunda gözlendi. SBS değerleri üzerinde sinterizasyon yöntemlerinin istatistiksel açıdan anlamlı etkisi bulunurken (p=0.006) monolitik zirkonyanın renkli olma özelliğinin anlamlı etkisi görülmedi (p>0.05). Renksiz bloklarda, KS (25.13±8.47) grubunda HS (14.89±7.08) grubuna göre istatistiksel olarak yüksek değerler bulundu (p=0.009). Renkli bloklarda ise HS (17.99±5.21) ve KS (20.89±7.31) grupları arasındaki farkın istatistiksel açıdan anlamlı olmadığı görüldü (p>0.05). Hem hızlı hem de konvansiyonel sinterizasyonda ise Z ve RZ grupları arasında anlamlı bir farklılık bulunmadı (p>0.05).
Sonuç: Farklı sinterizasyon yöntemlerinin, renksiz monolitik zirkonya bloklar ile adeziv siman arasındaki makaslama bağ dayanımını etkilerken renkli monolitik zirkonya bloklar ile adeziv rezin siman arasındaki makaslama bağ dayanımını etkilemediği bulundu. Blokların önceden renklendirilmiş veya renklendirilmemiş olması, monolitik zirkonya ile adeziv siman arasındaki makaslama bağ dayanımını etkilemedi.
Anahtar Kelimeler: Hızlı sinterizasyon, konvansiyonel sinterizasyon, makaslama bağ dayanımı, monolitik zirkonya, renklendirilmiş blok
Kürleme Modunun İki Farklı Bulk Fill Kompozitin Renk Değişimine Etkisi
Authors: BATMAZ Sevde Gül , YILDIZ Berkan , DÜNDAR Ayşe , BARUTÇUGİL Çağatay 
Published: December 2023

Amaç: Bu çalışmanın amacı iki farklı kürleme modunda ışıklanan iki farklı bulk fill kompozit rezinin, 1 hafta boyunca distile su, şarap ve kahvede bekletilmesiyle meydana gelen renk değişimlerinin değerlendirilmesidir.
Gereç-Yöntemler: Bu çalışmada A2 renginde iki farklı bulk fill kompozit rezin kullanılmıştır: Sonic Fill 2 (SF) (Kerr, ABD) ve Filtek Bulk Fill (FBF) (3M ESPE, ABD). Örnekler 5 mm çapında, 2 mm kalınlığında bir teflon kalıp kullanılarak hazırlanmıştır. Örnekler bir LED ışık cihazı (VALO Ultradent, South Jordan, UT) ile iki farklı kürleme modunda (standart güç modu-1000 mw/cm²-20 sn ve ekstra güç modu 3200 mw/cm²-3 sn) polimerize edilmiş, toplam 60 numune hazırlanmıştır. Renklendirme işlemlerine başlamadan önce örneklerin renk değerleri spektrofotometre (VITA Easyshade V, VITA Zahnfabrik, Almanya) kullanılarak ölçülmüştür. Ardından örnekler, üç farklı sıvıda 1 hafta boyunca bekletilmiştir. Renklendirme işlemleri tamamlandıktan 24 saat sonra renk ölçümü tekrarlanmıştır. Renk değişimi değerlendirmesi CIEDE2000 formülü kullanılarak yapılmıştır. Çalışmada elde edilen veriler SPSS Windows 25.0 (SPSS Inc., Chicago, IL, USA) programı kullanılarak analiz edilmiştir. Anlamlılık düzeyi p
Mental Foramenin Panoramik Radyografi ve Konik Işınlı Bilgisayarlı Tomografi Görüntüleri Üzerinde Morfolojik Analizi
Authors: UZUN Ezgi , APAYDIN Burak Kerem , TİL Ayşen 
Published: December 2023

Amaç: Bu çalışmanın amacı; bir grup Türk alt popülasyonunda mandibular dişlerin köklerine göre mental foramenin (MF) horizontal, vertikal konumunu ve anterior loop (AL) görülme sıklığını panoramik radyografi ve konik ışınlı bilgisayarlı tomografi (KIBT) görüntüleri üzerinden değerlendirmekti. Ayrıca her iki görüntüleme yöntemi arasında AL görülme sıklığını tespit etmede fark olup olmadığını belirlemekti.
Gereç ve Yöntemler: Bu çalışmaya dahil edilme/dışlama kriterini sağlayan 16 ile 80 yaşları arasında 435 hasta dahil edilmiştir. Mental foramenin horizontal konumu mandibular 1. premolar diş (PM1), mandibular 2. premolar diş (PM2) ve mandibular 1. molar dişe göre, vertikal konumu da PM1’nin ve PM2’nin apekslerini birleştiren yatay çizgiye göre belirlenmiştir. AL görülme sıklığı ise inferior alveolar sinirin üç farklı yapıda sonlanmasına göre değerlendirilmiştir. Verilerin normal dağılıma uygunluğu Kruskal Wallis ve Shapiro Wilk testi ile analiz edilmiş olup, kategorik değişkenler arasındaki farklılıkların saptanmasında ki-kare analizi kullanılmıştır. Gerekli koşullarda Yates düzeltmesi ve Fisher Exact testi kullanılmıştır. p
Avülsiyon Yaralanmalarının Acil Müdahalesinde Hasta Bilgi Kaynağı Olarak Türkçe YouTube™ Videolarının Güvenilirliği: Kesitsel İçerik Analizi
Authors: CAGAY SEVENCAN Gülçin , YAVŞAN Zeynep Şeyda 
Published: December 2023

Amaç: Bu çalışmanın amacı, avülsiyonun acil müdahalesinde Türkçe YouTube™ videolarının hasta bilgi kaynağı olarak, içerik ve kalitesinin değerlendirilmesidir.
Gereç ve Yöntemler: YouTube™ videolarının değerlendirilmesi için ‘avülsiyon, diş travması, diş yaralanmaları ve dişin yerinden çıkması’ anahtar kelimeleri kullanıldı. Videolar dahil edilme ve hariç tutulma kriterlerine göre titizlikle incelendi. Seçilen videoların içerikleri, Uluslararası Dental Travmatoloji Derneği’nin son tedavi rehberinin avülsiyon yaralanmalarında uygulanması gereken önermelere göre, 9 puanlık bir yararlılık skoru ile puanlandı. Yararlılık skoruna göre video içeriği; zayıf (0-3), orta (4-6) ve mükemmel (7-9) şeklinde üç gruba ayrıldı. Videoların kalitesinin değerlendirilmesinde, videoların genel kalitesini derecelendiren Küresel Kalite Ölçeği (GQS) kullanıldı. Videoların güvenilirliği DISCERN güvenirlik aracına göre puanlandı. İstatistiksel analizler yapıldı.
Bulgular: Toplam 240 video analiz edildi ve dahil edilme kriterlerine uyan 33 video çalışmaya dahil edildi. Video yükleme kaynağının en çok özel klinik/özel hastaneler olduğu (% 36.4; n=12), fakat bu kuruluşlar tarafından yüklenen videoların çoğunun zayıf içerikli olduğu görüldü (% 66.7; n=8). Videoların hedef kitlesinin çoğunlukla hastalar (% 78.8; n=26) olduğu görüldü. Videoların yararlılık skoruna göre, % 45.5’i zayıf, % 30.3’ü orta ve % 24.2’si mükemmel olarak sınıflandırıldı.
Sonuç: YouTube™ genellikle avülse dişlerin yönetimi ile ilgili düşük yararlılığa sahip videolar sunmaktadır. Bu nedenle, diş hekimleri bu kaynağın farkında olmalı ve hastaları/ebeveynleri YouTube™ videolarındaki bilgilerin güvenilirliği ve yanıltıcı içerik barındırabileceği konusunda uyarmalıdır.
Anahtar Kelimeler: Acil Müdahale, Avülsiyon, Travma, YouTube™
The Effect of High Nitric Oxide Concentrations on Oxygenators in Cardiopulmonary Bypass Machines (Experimental Study)
Authors: Radovskiy A. M. , Vorotyntsev I. V. , Atlaskin A. A. , Petukhov A. N. , Kryuchkov S. S. , Atlaskina M. E. , Stepakova A. N. , Marichev A. O. , Barygin E. K. , Osovskikh V. V. , Selemir V. D. , Buranov S. N. , Golovanov V. V. , Shirshin A. S. , Valueva Yu. V. , Pichugin V. V. , Domnin S. E. , Bautin A. E. 
Published: December 2023

The aim of the study. To study the effect of high nitric oxide concentrations on hollow polypropylene fibers of oxygenators.Materials and methods. The study was conducted in two stages. At the first stage, we evaluated the stability of oxygenator membrane made of hollow polypropylene fibers after six hours of exposure to air-oxygen mixture containing NO at 500 parts per million, or 500 pro pro mille (ppm) concentration, using mass spectrometry and infrared spectroscopy. At the second stage, an experiment with cardiopulmonary bypass (CPB) was conducted on 10 pigs. In the study group (n=5) animals sweep gas was supplied to the oxygenator as an air-oxygen mixture with NO at 100 ppm. In the control group animals (n=5) an air-oxygen mixture was used without NO. The CPB lasted for 4 hours, followed by observation for 12 hours. NO, NO2 (at the inlet and outlet of the oxygenator), and the dynamics of methemoglobin were evaluated. After weaning of animals from CPB, the oxygenators were tested for leakproofness, and scanning electron microscopy (SEM) was performed.Results. The oxygenator made of polypropylene hollow fibers retained its gas transfer parameters after six hours of exposure to air-oxygen mixture containing NO at 500 ppm. Based on IR-Fourier spectroscopy findings, NO did not affect structural integrity of polypropylene membranes. NO added to gas mixture at 100 ppm did not increase NO2 to toxic level of 2 ppm in 91% of control tests during 4 hours CPB in pigs; mean value was 1.58 ± 0.28 ppm. Methemoglobin concentration did not exceed the upper limit of permissible level (3%), and there were no statistically significant differences with the control group. All tested oxygenators have passed the leakproofness test. According to SEM findings, larger amounts of fibrin deposits were found in the control group oxygenators vs study group.Conclusion. There were no negative effects of NO at 500 ppm concentration on the oxygenator membrane made of hollow polypropylene fibers. NO at 100 ppm in a gas-mixture supplied to oxygenators did not lead to an exceedance of safe NO2 and methemoglobin concentrations in an animal model. Reduced fibrin deposits on hollow fibers of polypropylene oxygenator membranes were observed when with NO at a level of 100 ppm was added to a gas mixture.
The Green Asset Ratio – same same but different?
Authors: Müller-Dethard Jan , Petras Matthias 
Published: December 2023

Abstract
The green asset ratio (GAR) is supposed to be the central indicator for the taxonomy alignment of the bank’s assets. However, we show that GARs may differ for one and the same bank between article 8 taxonomy reporting and pillar 3 disclosures, leading effectively to two GARs. We argue that this inconsistency may lead to confusion and incredibility among stakeholders.
Transformação Digital na Criação do PPG no MPSC
Authors: Hoffmann Carlos Alberto Kalinovski , Farias Gisela Rabelo 
Published: December 2023

A necessidade de transformação digital na educação corporativa é premente e requer esforço conjunto para superar os desafios típicos de inovação no setor público. Nesse sentido, o presente texto apresenta o contexto e os desafios da efetivação do programa de pós-graduação no , que inclui a articulação entre diferentes áreas do saber, tais como pedagogia, direito, administração e tecnologia da informação.
The role of transglutaminase 2 in regulation of the balance between autophagy and apoptosis in tumor cells
Authors: Gnennaya Yu. A. , Semenov O.  M. , Barlev N. A. 
Published: December 2023

In normal tissue, cellular homeostasis is largely driven by two catabolic pathways: apoptosis and autophagy. Apoptosis, or programmed cell death, is regulated by pro-apoptotic factors, and promotes the removal of problematic cells. Autophagy, which in turn includes three forms: macro-, micro-, and chaperone-mediated autophagy, can promote both cell survival by selectively removing potentially apoptosis-inducing factors and raising the threshold of stress required for the induction of cell death. Recently, evidence has been accumulating suggesting the existence of common molecular pathways between autophagy and apoptosis, as well as the influence of the extracellular matrix on these processes. One of the important enzymes involved in the coordination and regulation of these processes is transglutaminase 2 (TG2). Different types of TG2 activities are involved in maintaining the dynamic balance between extracellular matrix and intracellular autophagy/apoptosis processes, while dysregulation of these processes may contribute to the pathogenesis of various human diseases, including oncogenesis. For example, TG2 can promote the degradation of pro-apoptotic proteins and the survival of renal cell carcinoma cells under nutrient-deficient conditions by modulating the autophagy process. In cells of various tissues deprived of TG2, aggregates of ubiquitinated proteins and damaged mitochondria are observed, which in turn induces proteotoxic stress and cell death. conversely, the transamidase activity of TG2 was observed to inhibit anti-apoptotic signaling in a human leukemic monocytic lymphoma model. In the present review, a number of important functions of TG2 in oncogenesis are described, along with the dual role of TG2 in modulating such opposite processes as cell survival and cell death.
Molecular features of gastrointestinal stromal tumors “wild-type” (<i>KIT/PDGFRA</i> WT)
Authors: Mazurenko N. N. , Yugay V. V. , Tsyganova I. V. 
Published: December 2023

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Their main features are the expression of CD117 (KIT) and mutations of KIT or PDGFRA in 85 % of patients. however, 10–15 % of adult GIST and 85 % of pediatric GIST do not have KIT/PDGFRA mutations (KIT/PDGFRA WT GIST or “wild-type” GIST). The prognosis and clinical course of these tumors and GIST with KIT/PDGFRA mutations differ. “Wild-type” GIST are quite heterogeneous group of tumors in terms of clinical phenotype, genetic etiology, and molecular pathways. Gastrointestinal stromal tumors are divided into SDH-deficient and SDH-competent based on the succinate dehydrogenase (SDH) complex. SDH-deficient GIST occur predominantly in children and young patients with Carney–Stratakis syndrome and Carney triad; there are also sporadic tumors. More than half of SDH-deficient GIST contain mutations in SDHA, SDHB, SDHD or SDHC, while the rest are caused by hypermethylation of the SDHC promoter. SDH-competent “wild-type” GIST include tumors with BRAF, RAS, or NF1 mutations that activate the RAS-RAF-MAPK pathway and KIT/PDGFRA/SDH/RAS-P WT GIST subtype or “quadruple wild type” GIST. The genomic profiles of these tumors and GIST with KIT/PDGFRA mutation or SDH deficiency differ significantly. One of the features of “quadruple wild type” GIST is activation of the FGFR (fibroblast growth factor receptors) signaling pathway due to chimeric FGFR, FGFR mutations, or overexpression of FGF (fibroblast growth factor). Another feature is chimeric genes containing fragments of NTRK, BRAF, FGFR and other genes that behave as oncogene drivers. In “quadruple wild-type” GIST the somatic mutations in TP53, MAX, MEN1, CTNND2, CHD4, ARIDIA and other genes were revealed as well as in the cell cycle genes RB1, CDK4, CDKN1B. There is no specific treatment for patients with “wild-type” GIST; the choice of drug is determined by the genetic disorder. There is a need to improve our understanding of the molecular mechanisms underlying the different GIST subtypes to develop more effective therapeutic approaches.
Effect of Tetrahydrocurcumin Compared to Curcumin in Carbohydrate Metabolism and Glycoprotein Components in Type 2 Diabetes - Systematic Review
Authors: Murugan Pidaran , Maneemegalai Sivaprakasam 
Published: December 2023

Pancreatic β-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes mellitus. Treatment of diabetes without any side effects is still a challenge to the medical system. There is an increasing demand by patients to use the natural products with antidiabetic activity, because insulin and oral hypoglycemic drugs are having so many side effects. Curcumin is a biologically active component isolated from the rhizome of Curcuma longa that possess antidiabetic and has been proven scientifically to possess high antioxidant activity and anticancer properties. Tetrahydrocurcumin (THC) is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in THC research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that THC exerts antidiabetic effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. The activities of glycolytic enzymes such as hexokinase and glucose-6-phosphate dehydrogenase were found to be decreased whereas the activities of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) and polyol pathway enzyme-sorbitol dehydrogenase were significantly increased in diabetic control rats. In addition, the oligosaccharide moieties of glycoproteins (hexose, hexosamine, fucose and sialic acid) were also significantly increased in plasma and tissues of diabetic control rats. THC and curcumin administration to diabetic rats significantly reversed the above changes when compared to diabetic control rats. In diabetic controls, hepatic and skeletal muscle glycogen content was decreased significantly as compared to non-diabetic controls. Treatment with THC and curcumin increased the hepatic and skeletal muscle glycogen significantly. The antidiabetic and antioxidant effects of THC are more potent than those of curcumin at the same dose. The antihyperglycemic action of THC might be mediated via an enhancement of insulin action, as it is evidenced by the increased levels of insulin in diabetic rats treated with THC, which may be responsible for the reversal of changes in carbohydrate enzymes and glycoprotein components. The THC administration showed more effective than curcumin.
Investigation On the Larvicidal Potential of Endophytic Fungi Isolates from Psoralea corylifolia And Leptadenia reticulata Against Aedes Aegypti
Authors: Rai Sadhana , Anuradha J. , Sanjeevi R. 
Published: December 2023

Globally, several million peoples are infected with epidemic-prone mosquito-borne diseases like yellow fever and malaria that is transmitted to humans by the bites of infected mosquitoes. Psoralea corylifolia, often known as babchi, is a well-liked herb that has been utilised in traditional Ayurvedic and Chinese medicine for many years for its miraculous abilities to treat a variety of skin conditions and Leptadenia reticulata, also known as Jivanti is an herb that is traditionally used in treating the conditions like malaria, diabetes, and liver disorders. The present study investigated the larvicidal properties of endophytic fungi isolated from Psoralea corylifolia and Leptadenia reticulata against Aedes aegypti. The highest larvicidal activity was seen in Trichodermata viride and Candida albicans species from leaves of L. reticulata was found to be 85.71% and 90.47 at 20 ppm. Likewise, Piriformospora indica and Aspergillus niger species from the leaves of P. corylifolia was found to be 66.66% and 83.33 % respectively. Candida albicans from leaves of L. reticulata and Aspergillus niger from the leaves of Psoralea corylifolia showed the highest mortality percentage was found to be 90.47 and 83.33 at 20 ppm respectively. The present study reveals the determination of optimal, eco-friendly, and selective mosquito larvicidal agents. The development of innovative and affordable medications to combat diseases spread by mosquitoes will be aided by more research on the isolation, characterisation, and determination of the mechanism of action against the selective mosquitos.
Features of providing specialized care to gynecological patients under conditions of new coronavirus infection COVID-19 pandemic
Authors: Kalinkina O. B. , Tezikov Yu. V. , Lipatov I. S. , Sreseli G. M. 
Published: December 2023

Objective. To study the features of providing a specialized care to gynecological patients in conditions of the pandemic of new coronavirus infection COVID-19 by the results of the work of Gynecological Unit of Samara Regional Clinical Hospital (SRCH) named after V.D. Seredavin.
Materials and methods. The results of the work of gynecological unit of SRCH for the period of 2019–2021 were analyzed. Annual reports on the work of this institution were used.
Results. The Gynecological Unit of SRCH named after V.D. Seredavin consists of 37 beds. Since 2017, on the basis of this unit Regional Urogynecological Center was organized. In 2021, the work of the unit was adapted to rendering medical care in pandemic conditions. The number of operations increased compared with 2020: in 2021–3134, in 2020–2782. The number of bed-days after the surgery reduced: in 2021–4.79 (in 2020–5.03), an average bed-day decreased: in 2021–5.96 (in 2020–6.18). The quantity of hospitalizations raised in 2021–1672 (in 2020–1591).
Conclusions. In the most severe conditions of pandemic, the gynecological unit managed to preserve its surgical activity; the volume of medical care corresponded to the plan. A proper organization of work with regard to all requirements of antiepidemic safety provided the absence of the postoperative complications.
Bottom-up vs. top-down: how participatory design can be used to help define post-conflict cultural memory in Croatia
Authors: Jolic Antonia 
Published: December 2023

Ethnic tensions and a constitutional crisis brought about the disintegration of Yugoslavia, which resulted in Croatia loosening ties with the Federation and subsequently declaring its independence. The quest for Croatian independence led to the Homeland War which took place between 1991–1995. The post-conflict transformation of the country primarily concentrated on the political and economic aspects of reconstruction, however the importance of developing a national strategy to deal with cultural memory, as part of the rebuilding process, has largely been neglected. Through a series of case studies, this paper will reveal how a significant proportion of Croatia’s cultural memory is dealt with through various forms of community engagement, centering around local civic organisations that “sprung up” as a consequence of the Homeland War. These communities are staging memorials, not just as places and occasions to gather around grief, but as means of highlighting the self-expression of loss in a public setting. Technological advancements, especially open-source access to new media, has encouraged more personal and community initiated and driven projects. Centered around participatory design, these projects demonstrate a more inclusive approach that enables local communities to record, collect and communicate their cultural memory, rather than rely on ‘approved’ state institutions. This article looks at how participatory design can aid in bridging and preservation of cultural memory of the Homeland War through the development of a participatory design framework which could be used as a central reference point to facilitate participatory projects between cultural institutions and their patrons, thus creating a more empowering approach to post-memory.