bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Substitute and the Excuse
Authors: Ulrich Katie 
Published: November 2023

Amid climate change and produced unevenness in geopolitical development, the question of how sustainability and growth might be brought together is a concern for many scientists of renewable energy in the Global South. This article explores answers offered by scientists in São Paulo, Brazil, who make renewable fuels and materials from sugarcane. Drawing on ethnographic fieldwork and tracing the “material of growth,” the article analyzes the traffic between sugarcane biological growth, industry growth, and economic growth in the context of the crop’s history of colonial expansion and environmental destruction. It argues that some scientific practices lay the molecular foundations for a substitutive “sustainable growth” that replicates petro-extractivist growth. Others allow for further permutations of how sustainability and growth might go together, particularly when scientists use sugarcane renewables as an excuse to develop other research aims. The article contributes to anthropological understandings of science, energy cultures, technical practices, and transition.

RESUMO

Em meio a um contexto de aquecimento global e de desigualdades produzidas no desenvolvimento geopolítico, a questão de como sustentabilidade e crescimento podem andar juntos é uma preocupação para muitos cientistas de energia renovável no Sul Global. Este artigo explora respostas concedidas por cientistas de São Paulo, Brasil, que produzem biocombustíveis e materiais renováveis a partir da cana-de-açúcar. Com base em trabalho de campo etnográfico e no rastreamento do “material do crescimento,” o artigo analisa a circulação entre o crescimento biológico da cana-de-açúcar, o crescimento da indústria, e o crescimento econômico no contexto da história canavial de expansão colonial e destruição ambiental. Argumento que algumas práticas científicas lançam as bases moleculares para um “crescimento sustentável” substitutivo que replica o crescimento petroextrativista. Já outras possibilitam novas configurações conjuntas de sustentabilidade e crescimento, particularmente quando cientistas usam produtos renováveis feitos a partir da cana-de-açúcar como desculpa para desenvolver outros objetivos de pesquisa. O artigo contribui para a compreensão antropológica da ciência, culturas energéticas, práticas técnicas, e transição.
Gaining Voice through Injury
Authors: Sandoval-Cervantes Iván 
Published: November 2023

Activism in favor of non-human animals is on the rise throughout Mexico despite ongoing and episodic violence. Activists, also known as animalistas, represent themselves as the “voice” of non-human animals as they seek rights and well-being for animals. In Ciudad Juárez, a border city once considered the most dangerous city in the world (2008–2012), animalistas engage in complex ways with non-human bodies as they seek to “speak” for them. This article analyzes the relationship between injured bodies and voice in Ciudad Juárez’s animalista movement, with the act of the rescue as the point of inception. Injured animal bodies prove central for activists because anthropogenic violence transforms dogs’ bodies. Non-human injured bodies, and their visual representations, allow animalistas to position themselves as the voice of an animal that survived an abuse while also individualizing and depolitizicing—through the discourse of pathology—violence against dogs.

RESUMEN

A pesar de la violencia continua y esporádica en México, el activismo a favor de los animales no humanos ha incrementado. En la búsqueda de derechos y el bienestar de animales no-humanos, las personas activistas, o animalistas, se presentan a sí mismas como la “voz” de los animales. En la ciudad fronteriza de Ciudad Juárez, que alguna vez fue consideraba la más violenta del mundo (2008–2012), las animalistas se relacionan de manera compleja con los cuerpos no-humanos para poder “hablar” por ellos. Este artículo analiza la relación entre cuerpos lesionados y voz en el movimiento animalista de Ciudad Juárez, enfatizando el acto del rescate como un momento clave. Los cuerpos lesionados de perros son fundamentales para las activistas porque la violencia antropogénica los transforma. Así los cuerpos animales lesionados, y sus representaciones visuales, les permiten posicionarse como la voz de animales sobrevivientes al abuso, mientras que individualiza y despolitiza—a través de un discurso patologizante—la violencia contra perros.
Modifying assessment tasks to ensure learning occurs in the era of artificial intelligence
Authors: Palmer Edward 
Published: November 2023

The launch of ChatGPT 3.5 in November 2022 has had a profound influence on teaching and learning from both students’ and staff members’ engagement. It is unclear how students are engaging with AI in creating submissions for assessments tasks, potentially impacting their learning. It is also unclear how educators are modifying their assessment design and how this may be impacting the learning outcomes of their cohorts. University systems run at a slow pace meaning that policies, course and program changes are not able to engage at the rate staff need in order to respond to this new technology. Staff have been left to deal with the use of AI in assessment tasks, often with little guidance or sufficient digital skills to make relevant changes or modifications.

This workshop will focus on the role of Artificial Intelligence (AI) and assessment. Participants will be given structured activities to understand and develop activities that provide learning for students without being compromised by artificial intelligence. They will apply their learning in the workshop to an assessment they are using or plan to use.
Harnessing H5P for Asynchronous Active Learning
Authors: Bui Nguyen , Brooks Claire 
Published: November 2023

Active learning, as defined by Bonwell and Eison (1991), involves students in doing things and thinking about what they are doing. Extensive research has highlighted the numerous benefits of active learning, including increased attendance rates (Kozanitis & Nenciovici, 2022), improved learning outcomes (Ruiz-Primo et al., 2011), reduced achievement gaps for underrepresented students (Haak et al., 2011; Theobald et Al., 2020), higher-order thinking skills, and enhanced student performance (Freeman et al., 2014). In comparison to traditional lectures, any form of active learning has proven to be beneficial to student learning (Schneider & Preckel, 2017). However, most research on active learning has focused predominantly on face-to-face synchronous classrooms, with little attention to active learning in online asynchronous environments. This presents an opportunity to explore design solutions that promote active learning in these asynchronous settings where students lack real-time interactions with educators and peers.

The advent of HTML5 (HyperText Markup Language version 5) or H5P has the potential to revolutionise active learning in online learning settings. As a free and open-source content creation tool, H5P offers various interactive and engaging content types that enable students to interact directly with course material in meaningful ways. This interactivity encourages students to participate actively in their learning process rather than passively obtaining information from lectures.

Drawing from two case studies conducted at an Australian university, this presentation highlights how H5P can be used to enhance active learning in online asynchronous courses. The first case study investigates the design of H5P training modules for a platform that supports researchers in humanities and social sciences in their sensitive data access management. This platform is part of a nation-wide project involving 12 partnering institutions and government agencies in Australia. The second case study explores the implementation of H5P learning activities in a Vietnamese language course over three years. In both cases, H5P is used as a plug-in within the Moodle learning platform.

Data collection for these case studies included interviews with educators and learning designers, Moodle reports, and participant feedback surveys. The findings from the thematic analysis and the learning analytics revealed substantial benefits of using H5P for active learning, along with the technical and pedagogical challenges encountered during the design process. The presentation features exemplary cases and insights from the case studies to suggest H5P design solutions that foster active participation, reflective thinking, and knowledge construction for students in online asynchronous settings.
Building a Digital Education Library
Authors: Grono Stephen , Mitchell Melissa , Palad Max 
Published: November 2023

As a formal institutional structure, university libraries represent at their core the collective knowledge and opportunity for deep personalised learning and professional development across the traditionalist subject matters. As professionals working within rapidly-evolving fields of online learning, in particular those around Learning Design, we do not have this same level of access or historical record as more traditional subjects (Elmborg, 2011). The Digital Education Library is an exploration of bridging this gap in a collaborative, co-curated, less formal approach to professional development.

In adapting the library structure to meet the needs and breadth of our team, we also have the opportunity to modernise for access and inclusion. This design accounts for the needs of modern hybrid work models and encourages recognition of the breadth of skills, knowledge, and interests existing within our own team structures. The [institution]’s Digital Education division comprises of four smaller areas; a Learning Design, Learning Media, Learning Environments, and Exams & e-Assessments teams, under its broader banner. These interconnected roles each add value and contexts to library content and design (Ilahi et al., 2019). With a diverse team from dispersed locations, curation and access to digital resources and physical books are embedded in the design to normalise and facilitate hybrid teams.

With these factors considered, building a Digital Education library gathers a broad range of themes related to third space design needs. The platform chosen utilises a hybrid approach (UNESCO, 2003), alongside a physical library of works, focused on not just instructional design, but a broad range of adjacent themes related to the areas of the Digital Education division – assessment design, media and graphic design, user experience, learning design, academic development, as well as works focused on the scholarship of teaching & learning, leadership, team culture, and data literacy. The range of themes explored is intentionally designed to foster partnerships between areas of the team, and hold intentional and visible space for professional development. Agency within the team is also fostered through opportunity for co-creation, through the option for team members to easily share resources they’ve found interesting, with relevant tags, descriptors, and templates.
This presentation will explore the Digital Education Library and its design process, from its dual perspective roles as both a library of digital education, and a digital library of education.
Influence of metabolic stress and metformin on synaptic protein profile in SH‐SY5Y‐derived neurons
Authors: Yang Alex J. T. , Mohammad Ahmad , Finch Michael S. , Tsiani Evangelia , Spencer Gaynor , Necakov Aleksandar , MacPherson Rebecca E. K. 
Published: November 2023

AbstractInsulin resistance (IR) is associated with reductions in neuronal proteins often observed with Alzheimer's disease (AD), however, the mechanisms through which IR promotes neurodegeneration/AD pathogenesis are poorly understood. Metformin (MET), a potent activator of the metabolic regulator AMPK is used to treat IR but its effectiveness for AD is unclear. We have previously shown that chronic AMPK activation impairs neurite growth and protein synthesis in SH‐SY5Y neurons, however, AMPK activation in IR was not explored. Therefore, we examined the effects of MET‐driven AMPK activation with and without IR. Retinoic acid‐differentiated SH‐SY5Y neurons were treated with: (1) Ctl: 24 h vehicle followed by 24 h Vehicle; (2) HI: 100 nM insulin (24 h HI followed by 24 h HI); or (3) MET: 24 h vehicle followed by 24 h 2 mM metformin; (4) HI/MET: 24 h 100 nM insulin followed by 24 h 100 nM INS+2 mM MET. INS and INS/MET groups saw impairments in markers of insulin signaling (Akt S473, mTOR S2448, p70s6k T389, and IRS‐1S636) demonstrating IR was not recovered with MET treatment. All treatment groups showed reductions in neuronal markers (post‐synaptic marker HOMER1 mRNA content and synapse marker synaptophysin protein content). INS and MET treatments showed a reduction in the content of the mature neuronal marker NeuN that was prevented by INS/MET. Similarly, increases in cell size/area, neurite length/area observed with INS and MET, were prevented with INS/MET. These findings indicate that IR and MET impair neuronal markers through distinct pathways and suggest that MET is ineffective in treating IR‐driven impairments in neurons.
Abdominal aerobic endurance exercise reveals spot reduction exists: A randomized controlled trial
Authors: Brobakken Mathias Forsberg , Krogsæter Iben , Helgerud Jan , Wang Eivind , Hoff Jan 
Published: November 2023

AbstractThe existence of spot reduction, exercise‐induced local body fat reduction, has been debated for half a century. Although the evidence is equivocal, no study has applied aerobic endurance training closely matching interventions for energy expenditure. Sixteen overweight (BMI: 29.8 ± 3.3(SD) kg m−2) males (43 ± 9 years) were randomized to: (1) abdominal endurance exercise (AG), combining treadmill running at 70% HRmax (27 min) with 4 × 4 min (30%–40% maximal strength, 1RM) of torso rotation and abdominal crunches (57 min), 4 days⋅week−1 for 10 weeks; or (2) control group (CG) performing only treadmill running (45 min) at 70% HRmax. Local fat mass was measured by dual‐energy x‐ray absorptiometry (DEXA), along with 1RM, and pulmonary oxygen uptake (to control energy expenditure during training). Trunk fat mass decreased more (697 g, 3%, p < 0.05) in AG (1170 ± 1093 g, 7%; p < 0.05) than in CG (no change). Total fat mass (AG: 1705 ± 1179 g, 6%; CG: 1134 ± 731 g, 5%; both p < 0.01) and body weight (AG: 1.2 ± 1.2 kg, 1%, p < 0.05; CG: 2.3 ± 0.9 kg, 3%, p < 0.01) decreased similarly in AG/CG. Torso rotation (AG: 32 ± 16 kg, 39%, p < 0.01; CG: no change) and abdominal crunch 1RM (AG: 35 ± 16 kg, 36%, p < 0.01; CG: 13 ± 12 kg, 17%, p < 0.05) increased more (p < 0.05/0.01) in AG than CG. Abdominal endurance exercise utilized more local fat than treadmill running, indicating that spot reduction exists in adult males.
Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches
Authors: Wang Jun-Ling , Liu Ming-Sheng , Fu Yu-Dong , Kan Qiang-Bo , Li Chun-Yan , Ma Rong , Fang Zhe-Wei , Liu Hong-Xia , Li Meng-Xian , Lv Jia-Ling , Sang Peng , Zhang Chao , Li Hong-Wei 
Published: November 2023

Abstract
Non-small cell lung cancer (NSCLC) is often driven by mutations in the epidermal growth factor receptor (EGFR) gene. However, rare mutations such as G719X and S768I lack standard anti-EGFR targeted therapies. Understanding the structural differences between wild-type EGFR and these rare mutants is crucial for developing EGFR-targeted drugs. We performed a systematic analysis using molecular dynamics simulations, essential dynamics (ED), molecular mechanics Poisson–Boltzmann surface area, and free energy calculation methods to compare the kinetic properties, molecular motion, and free energy distribution between wild-type EGFR and the rare mutants’ structures G719X-EGFR, S768I-EGFR, and G719X + S768I-EGFR. Our results showed that S768I-EGFR and G719X + S768I-EGFR have higher global and local conformational flexibility and lower thermal and global structural stability than WT-EGFR. ED analysis revealed different molecular motion patterns between S768I-EGFR, G719X + S768I-EGFR, and WT-EGFR. The A-loop and αC-helix, crucial structural elements related to the active state, showed a tendency toward active state development, providing a molecular mechanism explanation for NSCLC caused by EGFR S768I and EGFR G719C + S768I mutations. The present study may be helpful in the development of new EGFR-targeted drugs based on the structure of rare mutations. Our findings may aid in developing new targeted treatments for patients with EGFR S768I and EGFR G719X + S768I mutations.
Pregnancy as a Metaphor of Self-Cultivation in Dawn
Authors: Mitcheson Katrina 
Published: November 2023

Abstract
Nietzsche employs the concept of pregnancy metaphorically at various points in his writings; discussing the pregnancy of philosophers (GM III 8, BGE 292), spiritual pregnancy (EH, Clever 3; GS 72) and being pregnant with thoughts or deeds (D 552). I explore how Nietzsche uses the notion of pregnancy in Dawn, arguing that it connects to the theme of self-cultivation. I employ the various associations that Nietzsche makes with pregnancy, including the unknown, selfishness, strangeness, and solitude, to elucidate Nietzsche’s understanding of self-cultivation. I show how the metaphor of pregnancy, in which we do not control what we give birth to, both expresses and helps us explore the problem of what, if the self is made up of and directed by many competing drives, shapes and directs self-cultivation. I argue that Nietzsche’s deliberate references to the context of Plato’s discussion of pregnancy involve a self-conscious challenge to Plato’s concept of the philosopher, and of philosophy, and a reimagining of what they will give birth to. The appropriation of Plato’s famous metaphor thus underscores how Nietzsche’s concept and method of self-cultivation contrasts to Plato’s care for the soul and is rooted in attentiveness to the body and its drives.
Mediation analysis method review of high throughput data
Authors: Han Qiang , Wang Yu , Sun Na , Chu Jiadong , Hu Wei , Shen Yueping 
Published: November 2023

Abstract
High-throughput technologies have made high-dimensional settings increasingly common, providing opportunities for the development of high-dimensional mediation methods. We aimed to provide useful guidance for researchers using high-dimensional mediation analysis and ideas for biostatisticians to develop it by summarizing and discussing recent advances in high-dimensional mediation analysis. The method still faces many challenges when extended single and multiple mediation analyses to high-dimensional settings. The development of high-dimensional mediation methods attempts to address these issues, such as screening true mediators, estimating mediation effects by variable selection, reducing the mediation dimension to resolve correlations between variables, and utilizing composite null hypothesis testing to test them. Although these problems regarding high-dimensional mediation have been solved to some extent, some challenges remain. First, the correlation between mediators are rarely considered when the variables are selected for mediation. Second, downscaling without incorporating prior biological knowledge makes the results difficult to interpret. In addition, a method of sensitivity analysis for the strict sequential ignorability assumption in high-dimensional mediation analysis is still lacking. An analyst needs to consider the applicability of each method when utilizing them, while a biostatistician could consider extensions and improvements in the methodology.
Die geschlossene Kapitalgesellschaft im europäischen Gesellschaftsrecht – Der steinige Weg von der SPE über die SUP zur SES
Authors: Poelzig Dörte 
Published: November 2023

Abstract

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Nachdem zunächst vor allem große Unternehmen im Blickpunkt des Europäischen Gesellschafts-rechts standen, liegt der Fokus jüngerer europäischer Reformdiskussionen verstärkt auf kleinen und mittleren Unternehmen (KMU). Alle bisherigen Bemühungen zur Schaffung einer europäischen Rechtsform für geschlossene Kapitalgesellschaften, insbesondere die Verabschiedung der SPE-VO und der SUP-RiLi, sind jedoch gescheitert. Nunmehr haben Frankreich und Deutschland mit der „Societas Europaea Simplificata“ (SES) einen neuen Versuch unternommen. Mit dem vorliegenden Beitrag soll untersucht werden, welche Lösungsvorschläge für die regelungsbedürftigen Konflikt-felder (Gläubigerschutz, Minderheitenschutz) bzw. die auf dem Weg zu einer europaweit einheit-lichen Regelung immer wieder auftretenden Hindernisse (u. a. Arbeitnehmermitbestimmung) der französisch-deutsche Entwurf anbietet und wie die Chancen auf eine Ausweitung in der EU stehen.
The Effects of Heavy Resisted Sled Pulling on Sprint Mechanics and Spatiotemporal Parameters
Authors: Stavridis Ioannis , Ekizos Antonis , Zisi Maria , Agilara Georgia-Olanemi , Tsolakis Charilaos , Terzis Gerasimos , Paradisis Giorgos 
Published: November 2023

Abstract
Stavridis, I, Ekizos, A, Zisi, M, Agilara, G-O, Tsolakis, C, Terzis, G, and Paradisis, G. The effects of heavy resisted sled pulling on sprint mechanics and spatiotemporal parameters. J Strength Cond Res 37(12): 2346–2353, 2023—This study examines the effects of 2 resisted sled sprinting (RSS) training programs: with a load corresponding to the running velocity associated with the apex of the individual velocity-power relationship (50%vdec), with a load equal to 10% of body mass (10% BM), and of an unresisted sprint training (URS). We measured the 30-m sprint performance in intervals of 5 m examining sprint acceleration, mechanical properties (theoretical maximal horizontal power [Pmax], force [F0], velocity [v0], slope of the force-velocity relationship [SFv], maximal ratio of horizontal-to-resultant force [RFmax], rate of decrease in RF [Drf]), and spatiotemporal parameters (step frequency [SF], step length [SL], flight time [FT], and contact time [CT]). Twenty-seven sprinters were randomly assigned into the 50%vdec, 10% BM, and URS groups, performing 12 sessions over 6 consecutive weeks (2 sets of 5 sprints per session). The 50%vdec group significantly improved (p < 0.05) their performance in all 30-m intervals. Posttraining, the 50%vdec group showed significantly increased P
max, F0, and RFmax (mean differences: 1.46 ± 1.70 W·kg−1, 0.51 ± 0.68 N·kg−1, and 0.17 ± 0.18%, respectively), compared with pretraining. The 50%vdec group achieved higher SF, whereas FT decreased postintervention. No significant changes (p > 0.05) were found in the performance and mechanical and spatiotemporal variables in the other groups. In conclusion, RSS training with a load of 50%vdec provides an effective loading stimulus to induce adaptations that improve sprint acceleration performance. The improvements are explained by greater amounts of force and power, efficient force application, and higher step frequencies.