bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambient temperature and preterm birth: A case‐crossover study
Authors: Terada Shuhei , Nishimura Hisaaki , Miyasaka Naoyuki , Fujiwara Takeo 
Published: November 2023

AbstractObjectiveTo investigate the association between ambient temperature and preterm birth (PTB) and to estimate the population attributable fraction (PAF) of PTBs due to low and high temperatures.DesignTime‐stratified case‐crossover design.SettingJapan (46 prefectures, excluding Okinawa), 2011–2020.Sample214 050 PTBs registered in the Japan Perinatal Registry Network database among 1 908 168 singleton live births.MethodsA quasi‐Poisson regression model with a distributed lag nonlinear model was employed to assess the associations between daily mean temperature and PTBs for a lag of 0–27 days in each prefecture. A random effects meta‐analysis was conducted by combining effect estimates from the 46 prefectures to estimate pooled relative risks (RRs). The PAFs of the PTBs due to below or above the mean of the 46 median temperatures (16.0°C) were calculated.Main outcome measuresPreterm singleton live births.ResultsThe association between daily mean temperature and PTB risk exhibited a U‐shaped curve. The adjusted RRs were 1.15 (95% confidence interval [CI] 1.05–1.25) at the mean of the 1st percentiles (0.8°C) and 1.08 (95% CI 1.00–1.17) at the mean of the 99th percentiles (30.2°C) of 46 prefectures, with 16.0°C as the reference temperature. Approximately 2.3% (95% CI 0.6–4.0) of PTBs were attributable to low temperatures.ConclusionsBoth low and possibly high temperatures were associated with an increased risk of PTBs. These findings may help to inform preventive measures for pregnant women.
Insurance coverage during transitions: Evidence from Medicaid automatic enrollment for children receiving supplemental security income
Authors: Rennane Stephanie , Sobol Danielle , Stein Bradley D. , Dick Andrew 
Published: November 2023

AbstractObjectivesTo analyze relationships between Medicaid automatic enrollment for child Supplemental Security Income (SSI) recipients and health insurance coverage during transitions.Data Sources and Study SettingMedical Expenditure Panel Study, 2000–2020 and National Survey for Children with Special Health Care Needs, 2001–2010.Study DesignLeveraging variation in SSI‐Medicaid automatic enrollment status across regions and over time, we estimate a regression model to quantify associations between automatic enrollment and insurance coverage. We validate our findings in the NS‐CSHCN.Data CollectionOur sample includes children receiving SSI for a disability. We also analyze a subsample of children newly enrolled in SSI.Principal FindingsAutomatic enrollment is associated with a statistically significant increase in insurance coverage. Expanding automatic enrollment to all states is associated with increases in Medicaid enrollment of 3% (CI 0.9%–6.7%) among all SSI children and 7% (CI 1.1%–13.9%) among children newly enrolled in SSI. We find similar decreases in uninsurance. Analysis in the NS‐CSHCN replicates these findings.ConclusionsMedicaid automatic enrollment policies are associated with increased insurance coverage for SSI children, particularly those transitioning into the program. Medicaid policy defaults could play an important role in reducing administrative burdens to improve children's coverage and access to care.
Evaluation of bone marrow findings in hemodialysis patients with erythropoietin‐resistant anemia
Authors: Yilmaz Mehmet , Karakuş Volkan , Kaya Egemen , İlhanlı Nevruz , Huddam Bülent 
Published: November 2023

AbstractIntroductionTreatment with erythropoietin‐stimulating agents (ESAs) is widely used in anemia of chronic kidney disease (CKD). Acquired ESA resistance is an important problem. The aim of this study is to examine the bone marrow findings in hemodialysis patients with ESA‐resistant anemia.MethodsThe data of 210 patients with acquired ESA resistance were reviewed retrospectively. The patients were divided into groups according to having diagnosis of dysplasia and hematological disease, and survival analysis was performed.ResultsA total of 26 patients were included in the study. While dysplasia was present in 10 (38.5%) patients, five of them were diagnosed hematologically. When survival analysis was performed between those with and without a hematological diagnosis, a difference in survival was observed against the group with the diagnosis (24.4 vs. 72 months, p = 0.045).ConclusionUnresponsiveness to ESA treatment in CKD patients or a decrease in one of the other cell lines along with hemoglobin, it would be appropriate to perform early bone marrow examination.
Long‐term follow‐up of unresectable adenoid cystic carcinoma of the trachea and bronchus treated with high‐dose proton beam therapy: A report of two cases
Authors: Nakamura Masatoshi , Ohnishi Kayoko , Nakazawa Kensuke , Shimizu Kei , Miyauchi Daigo , Mizumoto Masashi , Nakai Kei , Okumura Toshiyuki , Sakurai Hideyuki 
Published: November 2023

AbstractAdenoid cystic carcinoma (ACC) of the trachea is a rare disease that is slow growing and has a risk of distant metastasis. The standard treatment for ACC of the trachea is surgery, but this tumor is often unresectable. In definitive radiotherapy using photons for unresectable ACC of the trachea, it is sometimes difficult to deliver a sufficient dose to the target without exceeding the tolerable dose to the surrounding normal tissues. Here, we report two cases of ACC of the trachea that received a high dose (74 Gy [relative biological effectiveness]) of proton beam therapy and achieved long‐term survival.
How we can reduce the environmental impact of our operating theatres: a narrative review
Authors: Roscioli Robert , Wyllie Tracey , Neophytou Krystle , Dent Lana , Lowen Darren , Tan David , Dunne Ben , Hodgson Russell 
Published: November 2023

AbstractClimate change is projected to become the leading cause of adverse health outcomes globally, and the healthcare system is a key contributor. Surgical theatres are three to six times more pollutant than other hospital areas, and produce anywhere from a fifth to a third of total hospital waste. Hospitals are increasingly expected to make operating theatres more sustainable, however guidelines to improve environmental sustainability are lacking, and previous research takes a narrow approach to operative sustainability. This paper presents a narrative review that, following a ‘review of reviews’ approach, aims to summarize the key recommendations to improve the environmental sustainability of surgical theatres. Key domains of discussion identified across the literature included minimisation of volatile anaesthetics, reduction of operating theatre power consumption, optimisation of surgical approach, re‐use and re‐processing of surgical instruments, waste management, and research, education and leadership. Implementation of individual items in these domains has seen significant reductions in the environmental impact of operative practice. This comprehensive summary of recommendations lays the framework from which providers can assess the sustainability of their practice and for the development of encompassing guidelines to build an environmentally sustainable surgical service.
Effects of Italian ryegrass silage supplementation on feed intake and behavior of pregnant sows
Authors: Makalani Andrew L. , Kawashima Tomoyuki , Ishii Yasuyuki , Takahashi Toshihiro 
Published: November 2023

AbstractThis study aimed to assess the behavior and stress status of pregnant sows following supplementation with Italian ryegrass silage (IRS) and the impact of feeding the IRS on feeding costs. Six sows with an initial body weight (BW) of 238.6 ± 5.9 kg were allotted to a 6 × 3 Latin square design with a 5‐day acclimatization period followed by a 5‐day data collection period. A commercial diet was replaced by IRS on a dry matter (DM) basis up to 0%, 9%, and 13% in the control treatment and the two test treatments, respectively. Apart from collecting data on daily feed intake and BW, urine was collected, and video footage was recorded for the last day of each treatment for analysis of urinary cortisol and behavior. There were no leftovers with all diets and nutrient uptake was unaffected (p > 0.05), while BW gain decreased (p < 0.05) to be a limited range from 1% to 3%, with increased inclusion of IRS. Both the behavior of sows and cortisol concentration were unaffected (p > 0.05). Furthermore, it was estimated that feeding 13% DM of IRS would reduce feed costs by 17%. IRS would be acceptable in replacing up to 13% of the commercial diet and cutting feeding costs.
A population pharmacokinetic model of methotrexate in Korean patients with haematologic malignancy
Authors: Jung Yun Seob , Son Mijeong , Lee Sang‐Guk , Chong June‐Won , Kim Soo‐Jeong , Jang Ji Eun , Lyu Chuhl Joo , Hahn Seung Min , Han Jung Woo , Park Kyungsoo 
Published: November 2023

AimsThis study was conducted to develop a population pharmacokinetic (PK) model of methotrexate in Korean patients with haematologic malignancy, identify factors affecting methotrexate PK, and propose an optimal dosage regimen for the Korean population.MethodsData were retrospectively collected from 188 patients with acute leukaemia or non‐Hodgkin's lymphoma who were admitted to Severance Hospital during the period from November 2005 to January 2016. Using demographic factors and laboratory results as potential covariates for PK parameters, model development was performed using NONMEM and optimal dosing regimens were developed using the final PK model.ResultsA two‐compartment model incorporating body weight via allometry best described the data, yielding typical parameter values of 25.09 L for central volume of distribution (
), 17.65 L for peripheral volume of distribution (
), 12.89 L/h for clearance (CL) and 0.655 L/h for inter‐compartmental clearance in a 50 kg patient. Covariate analyses showed that, at the weight of 50 kg, CL decreased by 0.11 L/h for each 1‐year increase in age above 14 years old and decreased 0.8‐fold when serum creatinine level doubled, indicating the importance of age‐specific dose individualization in methotrexate treatment. Volume of distribution at steady state derived from PK parameters (=
+
) was 0.85 L/kg, which was similar to those in the Western or Chinese populations. Optimal doses simulated from the final model successfully produced the PK measures close to the target chosen.ConclusionsThe population PK model and optimal dosage regimens developed in this study can be used as a basis to achieve precision dosing in Korean patients with haematologic malignancy.
Attitudes and perceptions of cancer patients and healthcare providers towards prehabilitation: A thematic synthesis
Authors: Shen Chen , Gu Lianqi , Li Na , Wang Rao , Yang Xin , Chu Zhiping 
Published: November 2023

AbstractPurposePrehabilitation, which is the process of enhancing functional capacity before undergoing surgery or other treatments, has been shown to improve cancer patients' outcomes. Patient and healthcare provider attitudes and perceptions are essential factors in the successful implementation of prehabilitation. The purpose of this systematic review is to synthesize qualitative evidence and explore the barriers and facilitators to prehabilitation implementation.MethodsFrom the earliest available date to October 2023, 7 databases (PubMed, Web of Science, Cochrane Library, Embase, CINAHL, PsycINFO, and MEDLINE) were searched for a systematic review. Data were extracted, thematically analysed, and mapped onto the Capability, Opportunity, and Motivation Model of Behaviour (COM‐B). The Critical Appraisal Skills Programme (CASP) tool was used to assess the quality of the studies.ResultsA total of 26 studies were included, involving 377 patients, 51 caregivers, and 156 healthcare providers. 16 factors were identified and mapped onto the COM‐B model: reflective/automatic motivation, physical/social opportunity, physical/ psychological capability.ConclusionsPatients and healthcare provides identified a lack of reflective motivation and physical opportunities as the most significant barriers to engagement in prehabilitation. Personalized approaches, social support, and healthcare providers' engagement are key factors for prehabilitation. Future research should focus on developing effective interventions to enhance the uptake and sustainability of prehabilitation.
Autoantibody repertoire profiling in tissue and blood identifies colorectal cancer‐specific biomarkers
Authors: Zhang Pei‐Fen , Wu Ziyi , Zhou Ting , Yang Da‐Wei , Mu Quan‐Kai , Zhang Wen‐Bin , Yu Long , Zhang Shao‐Dan , Hu Ye‐Zhu , Mu Jianbing , Jia Wei‐Hua 
Published: November 2023

AbstractAutoantibodies (AAbs) in the blood of colorectal cancer (CRC) patients have been evaluated for tumor detection. However, it remains uncertain whether these AAbs are specific to tumor‐associated antigens. In this study, we explored the IgG and IgM autoantibody repertoires in both the in situ tissue microenvironment and peripheral blood as potential tumor‐specific biomarkers. We applied high‐density protein arrays to profile AAbs in the tumor‐infiltrating lymphocyte supernatants and corresponding serum from four patients with CRC, as well as in the serum of three noncancer controls. Our findings revealed that there were more reactive IgM AAbs than IgG in both the cell supernatant and corresponding serum, with a difference of approximately 3–5 times. Immunoglobulin G was predominant in the serum, while IgM was more abundant in the cell supernatant. We identified a range of AAbs present in both the supernatant and the corresponding serum, numbering between 432 and 780, with an average of 53.3% shared. Only 4.7% (n = 23) and 0.2% (n = 2) of reactive antigens for IgG and IgM AAbs, respectively, were specific to CRC. Ultimately, we compiled a list of 19 IgG AAb targets as potential tumor‐specific AAb candidates. Autoantibodies against one of the top candidates, p15INK4b‐related sequence/regulation of nuclear pre‐mRNA domain‐containing protein 1A (RPRD1A), were significantly elevated in 53 CRC patients compared to 119 controls (p < 0.0001). The project revealed that tissue‐derived IgG AAbs, rather than IgM, are the primary source of tumor‐specific AAbs in peripheral blood. It also identified potential tumor‐specific AAbs that could be applied for noninvasive screening of CRC.
Evaluation of dental education during the pandemic of COVID‐19—Results from an online survey among dental students
Authors: Glockner Sebastian , Payer Michael , Kirnbauer Barbara , Mischak Irene , Subbalekha Keskanya , Mattheos Nikos 
Published: November 2023

AbstractIntroductionThe aim of this study was to assess the students' experience with education during the COVID‐19 pandemic, as well as to investigate their views moving forward after resumption of face‐to‐face education.Materials and MethodsA questionnaire was administered to dental students in clinical dental education at seven dental schools. The questionnaire included 33 items organized in three sections: (a) Demographics, (b) Perceptions/activity during lockdown, and (c) Perceptions/activity upon resumption of face‐to‐face teaching.ResultsA total of 286 students from seven universities in Europe and Asia participated. Students' satisfaction with education during the pandemic varied among universities and ranged between 36%–80%, but students engaged in delivering emergency care had a significantly higher opinion (p = .001). Students who felt that their workload decreased, were commonly 24 years old or older (p = .015), male (p = .05) reported lower concentration and motivation, experienced a more severe disruption and valued lower the efforts of their universities to ensure the continuity of education (p = .009). The majority of the students (80.3%) felt confident to resume clinical training after the lockdown. In general, female students experienced a higher disruption of their education during the pandemic (p = .043) and expressed lower confidence to continue clinical training in comparison to their male colleagues (p = .001).ConclusionStudents’ perception of their workload during the COVID‐19 lockdown was very diverse, with those experiencing a reduction in workload being more likely to express lower satisfaction as well. Female students experienced a higher level of disruption. Engaging students in the delivery of emergency care had a positive effect on their appreciation of the education.
Differential patterns of basal and naloxone‐evoked dopamine efflux in the rat dorsal and ventral striatum following prolonged‐intermittent exposure to morphine
Authors: Ahn Soyon , Zou Haiyan , Seamans Jeremy K. , Phillips Anthony G. 
Published: November 2023

AbstractHypodopaminergia in the ventral striatum is a putative neurobiological correlate of withdrawal in opioid‐dependent individuals. This perspective stands in contrast to brain imaging studies with chronic opioid users showing that naloxone‐enhanced dopamine (DA) release in the dorsal striatum is positively correlated with withdrawal aversion. Here, we examined regional differences in striatal DA function associated with opioid withdrawal in rats exposed to intermittent morphine injections for 31 days. Basal concentrations of DA were reduced (i.e., indicating a hypodopaminergic state) in the ventral striatum on Day 10 of morphine exposure, whereas a more prolonged period of morphine treatment was required to reveal hypodopaminergia in the dorsal striatum on Day 31. The ventral striatum consistently exhibited naloxone‐induced transient reductions in DA below the hypodopaminergic basal levels, whereas morphine enhanced DA efflux. In the dorsal striatum, DA responsivity to naloxone shifted from a significant decrease on Day 10 to a notable increase above hypodopaminergic basal levels on Day 31, corroborating the findings in the human dorsal striatum. Unexpectedly, the magnitude of morphine‐evoked increases in DA efflux on Day 31 was significantly blunted relative to values on Day 10. These findings indicate that prolonged‐intermittent access to morphine results in a sustained hypodopaminergic state as reflected in basal levels in the striatum, which is accompanied by regional differences in DA responsivity to naloxone and morphine. Overall, our findings suggest that prolonging the duration of morphine exposure to 31 days is sufficient to reveal neuroadaptations that may underlie the transition from initial drug exposure to opioid dependence.
Telling a supervisor about experiences of gendered dismissal: Problems of documentation, tellability, and failed authority
Authors: Stevanovic Melisa , Olakivi Antero , Nevalainen Henri , Henttonen Pentti , Ravaja Niklas 
Published: November 2023

AbstractDifficulties of documentation characterize many problematic experiences of social interaction. Here, we study such difficulties by analyzing a case in which an employee tells her supervisor about the gendered dismissal that she has experienced at work. Using video‐recorded performance appraisal interviews as data and conversation analysis and positioning analysis as methods, we examine how the experience of gendered dismissal lends itself to a documentable issue. We describe the process by which the problem that the employee initially described as an organizational leadership issue became redefined as a personal matter, which was not the responsibility of the supervisor. We show how this happened by the supervisor refraining from treating the employee's problem as “tellable” on its own terms, which led to the employee repeatedly changing her storyline. We argue that the persistence of inequalities in organizational interactions may be due to documentation difficulties, which are anchored in cultural expectations that bias the tellability of events in ways that promote gender inequality.
Beyond the Polemics: Freedom and Necessity in Plotinus and St Maximus Confessor
Authors: Heide Daniel 
Published: November 2023

AbstractAbstract: The aim of this paper is to challenge the prevailing polemic between ‘necessary’ emanation and ‘free’ creation. I begin by arguing for the presence of freedom and volition in the emanationism of Plotinus. I then move on to explore the role of necessity in the creationism of Maximus. In both cases, I rely upon a twofold schematisation of freedom and necessity to dissolve the dichotomy between them effectively. Having levelled the playing field, so to speak, I conclude that, all things being equal, one does find in Maximus (and Christian thinkers generally) a heightened sense of divine volition and relationality beyond that of the pagan Neoplatonists. This greater emphasis upon the freedom of the divine will, however, has little bearing on whether Maximus's doctrine of creation is ‘emanationist’ or ‘creationist’. Instead, it stems from a biblically inspired sense of the One God as intimately involved in His creation which, though derived from God, is crucially other than God.
Sulfur‐rich mafic magma injection into the felsic magma chamber beneath Asama volcano, central Japan: Records in olivine‐hosted melt inclusions from the Itabana and Tenmei eruptions
Authors: Yamaguchi Yoshiaki , Auer Andreas , Miyagi Isoji 
Published: November 2023

AbstractEven though no basalts have erupted at Asama volcano, its large, felsic magma chamber standing beneath the summit is frequently replenished by cryptic injections of mafic magma of basalt‐basaltic andesite composition. This mafic magma is preserved within melt inclusions trapped in olivine phenocrysts collected from the old Itabana pumice of the Kurofu stage and the Tenmei pumice of the current Maekake stage. The trapped mafic melts provide a detailed and vivid record of cryptic mafic magma injection into the felsic chamber where they admix to erupt andesite magma. The main phenocrysts of plagioclase, orthopyroxene, and clinopyroxene, commonly seen in the erupted products, are derived from the felsic magmas and trapped felsic melts of dacite‐rhyolite compositions, containing low sulfur contents (0.3 wt% of SO3 or less; most are lower than 0.10 wt%). In contrast, the mafic melts, entrapped by olivine phenocrysts, show high concentrations of SO3, up to 1.06 wt% for Itabana and SO3 0.65 wt% for Tenmei. In addition, the olivine phenocryst commonly encloses early crystalline phases precipitated from the sulfur‐rich mafic magma, such as Cr‐spinel, Mg‐rich orthopyroxene, Fe, Cu, and Ni‐bearing sulfides, and often Al‐rich clinopyroxene. The olivine‐hosted mafic melt inclusions always contain numerous vesicles. Furthermore, they are often included as hourglass‐shaped trapped melts, exhibiting snapshots of intense foaming and gas phase exsolution during the olivine growth and probably in the process of the cryptic injection into the felsic magma beneath the Asama summit. Our new data contributes to a better understanding of the magmatic system of the Asama volcano but also highlight the importance of the “Excess sulfur problem”, especially concerning the 1783 Tenmai eruption, which was contemporary to the Laki Fires.