bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond the asylum
Authors: Mossa Alessandra 
Published: December 2023

AbstractMy research is situated within the literature looking at the processes of deinstitutionalisation of the mental health system through the lived geographies placed in between the walls of the asylum. It addresses mental health geographers' call for a situated knowledge about mental health and, by using the Italian psychiatric experience of the 1960s and 1970s as an example, stresses the importance of looking at care in both spatial and relational terms. Through a geographical understanding of the Italian psychiatric reform, that goes from Franco Basaglia's renowned work to the underrepresented experience of Turin, in northwest Italy, I will examine how space is intertwined with processes of mental health care. Additionally, I assess the role played by the interaction between spatial and relational elements in potentially enabling patients' self‐determination, empowerment and inclusion. The case of Turin—the story of which will be told through the analysis of archival material from a grassroots association called Associazione per la Lotta contro le Malattie Mentali—will serve to expand the common narrative around the Italian lesson and to give resonance to the instrumental role played at the time by both patients and civil society. By looking at the key events that led to the gradual dismantlement of the traditional psychiatric institutions in the metropolitan area of Turin, this paper contributes to the spatial turn in mental health studies, calling upon researchers to look at past achievements as something we still need to learn from and safeguard.
Cognitive decline in thrombotic thrombocytopenic purpura survivors: The role of white matter health as assessed by MRI
Authors: Hannan F. , Hamilton J. , Patriquin C. J. , Pavenski K. , Jurkiewicz M. T. , Tristao L. , Owen A. M. , Kosalka P. K. , Deoni S. C. L. , Théberge J. , Mandzia J. , Huang S. H. S. , Thiessen J. D. 
Published: December 2023

SummaryImmune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a rare condition caused by severe ADAMTS13 deficiency, leading to platelet aggregation and thrombosis. Despite treatment, patients are prone to cognitive impairment and depression. We investigated brain changes in iTTP patients during remission using advanced magnetic resonance imaging (MRI) techniques, correlating these changes with mood and neurocognitive tests. Twenty iTTP patients in remission (30 days post‐haematological remission) were compared with six healthy controls. MRI scans, including standard and specialized sequences, were conducted to assess white matter health. Increased T1 relaxation times were found in the cingulate cortex (p < 0.05), and elevated T2 relaxation times were observed in the cingulate cortex, frontal, parietal and temporal lobes (p < 0.05). Pathological changes in these areas are correlated with impaired cognitive and depressive scores in concentration, short‐term memory and verbal memory. This study highlights persistent white matter damage in iTTP patients, potentially contributing to depression and cognitive impairment. Key regions affected include the frontal lobe and cingulate cortex. These findings have significant implications for the acute and long‐term management of iTTP, suggesting a need for re‐evaluation of treatment approaches during both active phases and remission. Further research is warranted to enhance our understanding of these complexities.
Attentional bias in psoriasis: The role of processing time and emotional valence
Authors: Etty Sarah , George David N. , van Laarhoven Antoinette I. M. , Kleyn C. Elise , Walton Shernaz , Holle Henning 
Published: December 2023

AbstractPurposeThe present study explored whether people with psoriasis display an attentional bias towards disease‐related threat words and whether this bias occurs relatively early during the phase of stimulus disengagement, or during a later maintained attention phase dominated by controlled strategic processes. We also explored the degree to which attentional bias is dependent on the emotional valence of control words.MethodsIndividuals with psoriasis and matched controls took part in 4 online experiments. Participants completed a spatial cueing paradigm using disease‐related threat words and control words as cues, in order to obtain reaction time estimates of attentional bias.ResultsWe did not observe evidence for attentional bias when control words were matched with threat words for emotional valence, regardless of whether processing time for the cues was limited (Experiment 1: SOA = 250 ms) or extended (Experiment 2: SOA = 1050 ms). We also did not observe evidence for attentional bias when control words of positive valence were used, but processing time was limited (Experiment 3). An attentional bias was only observed (p = .012, Cohen's d = .37) when sufficient processing time was available and positively‐valanced control words were used (Experiment 4).ConclusionRather than showing large and generalized AB effects as predicted by previous accounts, our results tentatively suggest that AB in psoriasis is restricted to situations where participants have ample processing time and threat words are easily distinguishable from control words on the basis of emotional valence. The pattern of results suggests that attentional bias in psoriasis is best characterized as a relatively slow strategic process.
Motherhood and intellectual disability in Spain: Experienced difficulties and shared desires for change
Authors: Rio‐Poncela Ana María , Rojas‐Pernia Susana 
Published: December 2023

AbstractBackgroudDespite the advancements in the rights of persons with disabilities in Western countries, the motherhood of women with intellectual disabilities remains scarcely visible. The approval of the Convention on the Rights of Persons with Disabilities (2006) and its subsequent ratification by the Spanish Government (2008) recalls the obligation to fulfil the rights of persons with disabilities to found a family (art. 23) and to choose who they want to live with (art. 19). While the importance of this legislation is undeniable, the personal experiences of women with intellectual disabilities still demand effective changes.MethodsThis article reports the results of a study entitled Subjectivities and motherhood in women with intellectual disabilities. Reflections in dialogue through an inclusive research project. In this study, we delved into the stories of 13 women, aged between 24 and 72, to learn about their motherhood experiences (before, during and after making the decision of being mothers) and to identify the barriers and supports encountered. Methods for data collection included individual semi‐structured interviews, discussion groups and other narrative and visual resources (images and biograms).FindingsThis study explores in depth the obstacles identified by the participating mothers, which have been organised around six themes: (1) information and guidance on sexuality and family planning, (2) assistance of health services, (3) employment and housing situation, (4) child custody, (5) raising children, and (6) informal support. The participants encountered difficulties in all the above fields related to contextual factors. In other words, these barriers do not derive from individual issues centred on their disability, but from factors that often do not depend on mothers with intellectual disabilities, such as deprivation of socio‐educational opportunities.ConclusionsOur results show the nuanced ways in which these mothers were immersed in a social system that questions them as ‘good mothers’ and violates their rights. As we discussed, the participants' desires and decisions to engage and/or continue with motherhood constitute an exercise of resistance to this system.
Inhibiting cholesterol de novo synthesis promotes hepatocellular carcinoma progression by upregulating prostaglandin E synthase 2‐mediated arachidonic acid metabolism under high fatty acid conditions
Authors: Zhao Zhibo , Liu Xinyi , Xiang Yue , Hou Zhengping , He Kun , Zhong Guochao , Hu Jiejun , Cai Dong , Liu Yan , Ren Jihua , Gong Jianping , Zhao Lei 
Published: December 2023

AbstractInhibition of cholesterol de novo synthesis (DNS) by statins has controversial effects on the treatment of hepatocellular carcinoma (HCC). High fatty acid conditions have been reported to limit the effect of statins on metabolism diseases. Whether high fatty acid conditions interfere with the effect of statins on HCC remains unclear. Here, we reported that inhibiting cholesterol DNS with atorvastatin promoted the oncogenic capabilities of diethylnitrosamine (DEN) in mice fed high fatty acid diets (HFD). The combined analysis of metabolomics and transcriptomics revealed that arachidonic acid (AA) metabolism was the most significant changed pathway between mice with and without atorvastatin treatment. In vitro, in the presence of AA precursor linoleic acid (LA), atorvastatin promoted the proliferation and migration ability of HCC cell lines. However, in the absence of LA, these phenomena disappeared. TCGA and tissue microarray examination revealed that prostaglandin e synthase 2 (PTGES2), a key enzyme in AA metabolism, was associated with the poor outcome of HCC patients. Overexpression of PTGES2 promoted the proliferation and migration of HCC cell lines, and knockdown of PTGES2 inhibited the proliferation and migration of cells. Additionally, atorvastatin upregulated PTGES2 expression by enhancing Sterol‐regulatory element binding protein 2 (SREBP2)‐mediated transcription. Knockdown of PTGES2 reversed the proliferation and migration ability enhanced by atorvastatin. Overall, our study reveals that a high fatty acid background is one of the possible conditions limiting the application of statins in HCC, under which statins promote the progression of HCC by enhancing SREBP2‐mediated PTGES2 transcription.
Association of liver fibrosis with extrahepatic cancer in steatotic liver disease patients with PNPLA3 I148M GG genotype
Authors: Tai Jennifer , Hsu Chao‐Wei , Chen Wei‐Ting , Yang Sien‐Sing , Chiu Cheng‐Hsun , Chien Rong‐Nan , Chang Ming‐Ling 
Published: December 2023

AbstractThe impacts of patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M‐rs738409, methylenetetrahydrofolate reductase (MTHFR) Ala222Val‐rs1801133, and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys‐rs671 on the outcomes of Taiwanese patients with steatotic liver disease (SLD) have remained elusive. An 8‐year prospective cohort study of patients with (n = 546) and without (n = 580) SLD (controls) was undertaken in a Taiwanese tertiary care center. The 546 SLD patients comprised 306 (56.0%) men and 240 (44.0%) women with mean ages of 53.3 and 56.4 years, respectively. Compared with the controls, SLD patients had an increased frequency of the PNPLA3 I148M‐rs738409 GG genotype (25.5 vs. 5.9%, p = 0.001). Among the SLD patients, 236 (43.1%) suffered cardiovascular events, 52 (9.5%) showed extrahepatic cancers, 13 (2.38%) experienced hepatic events, including hepatocellular carcinoma (n = 3, 0.5%) and liver cirrhosis (n = 8, 1.47%), and none died. The Fibrosis‐4 (FIB‐4) scores were associated with extrahepatic cancer (hazard ratio [HR] 1.325; 95% confidence interval [CI], 1.038–1.691) and cirrhosis development (HR 1.532; 95% CI, 1.055–2.224), and the PNPLA3 I148M‐rs738409 G allele (β = 0.158, 95% CI, 0.054–0.325) was associated with the FIB‐4 score. Stratified analyses showed that the impact of the FIB‐4 score on extrahepatic cancer development was evident only in SLD patients with the PNPLA3 I148M‐rs738409 GG genotype (HR 1.543; 95% CI, 1.195–1.993) and not in patients with the GC or CC genotype. Moreover, the ALDH2 Glu504Lys‐rs671 G allele had a dose‐dependent effect on alcoholism, and the MTHFR and ALDH2 genotypes were not significantly associated with SLD patient outcomes. In conclusion, special vigilance should be exercised for emerging extrahepatic cancer in SLD patients with the PNPLA3 I148M‐rs738409 GG genotype and high FIB‐4 scores.
An ethnographic fieldwork: The role of school shows in the reproduction of gender inequalities in Turkey
Authors: Yılmaz Ayşe 
Published: December 2023

AbstractThis article explores the processes of creating school shows in primary schools in Turkey and examines how teachers reinforce particular gendered constructions of femininity and masculinity through children's bodies in the making of these performances. Drawing on the insights from the sociology of the body within childhood research, the article is based on an ethnography conducted in a costume shop in Istanbul where teachers rent costumes for the shows, as well as interviews with teachers preparing the shows and observations made during the performances. The research reveals that the shows perpetuate gender norms and stereotypes while reproducing inequalities.
Diagnoseverzögerung, komorbide Hidradenitis suppurativa und die prognostische Bedeutung bakterieller Kulturen bei Folliculitis decalvans: eine Kohortenstudie
Authors: Lyakhovitsky Anna , Segal Oz , Galili Eran , Thompson Curtis T , Tzanani Ido , Scope Alon , Baum Sharon , Barzilai Aviv 
Published: December 2023

ZusammenfassungHintergrundFolliculitis decalvans (FD) ist eine primäre neutrophile vernarbende Alopezie, die häufig zu irreversiblem Haarverlust führt. Daten zu Epidemiologie, klinischen Merkmalen, Folgen und prognostischen Faktoren sind nur eingeschränkt verfügbar.ZielDie Beurteilung einer Patientenkohorte mit FD sowie die Charakterisierung schwerer Krankheitsverläufe und prognostischer Faktoren, die eine Remission verhindern.Patienten und MethodenDiese retrospektive Kohortenstudie umfasste 192 Patienten, bei denen zwischen 2010 und 2020 an einem tertiären Zentrum eine FD diagnostiziert und die mindestens sechs Monate nachverfolgt wurden.ErgebnisseDie Diagnose wurde im Mittel um 22,2 (± 29,7) Monate verzögert gestellt. Komorbide Erkrankungen mit Okklusion der Haarfollikel waren häufig. In 45,6% der Fälle waren Bakterienkulturen positiv, am häufigsten mit Staphylococcus (S.) aureus. Schwere Krankheitsverläufe waren mit komorbider Hidradenitis suppurativa und positiver Bakterienkultur, insbesondere S. aureus, assoziiert. Bei 50,7% der Patienten kam es zu vollständiger Remission: Bei 32% innerhalb der ersten sechs Monate der Behandlung und bei 18,7% während der Nachkontrolle. Rezidive waren häufig. Negative Prognosefaktoren bezüglich der Remission waren jüngeres Alter und positive Bakterienkultur.SchlussfolgerungenEs besteht Bedarf hinsichtlich der Ausbildung von Dermatologen, um die Diagnoseverzögerung zu reduzieren. Das Screening von FD‐Patienten auf komorbide Hidradenitis suppurativa und Bakterienkulturen sind wichtig für die Behandlungsplanung.
Hohe Rezidivrate des Eczema herpeticatum bei mittelschwerer bis schwerer atopischer Dermatitis – eine TREATgermany Registeranalyse
Authors: Traidl Stephan , Heinrich Luise , Siegels Doreen , Rösner Lennart , Haufe Eva , Harder Inken , Abraham Susanne , Ertner Konstantin , Kleinheinz Andreas , Schäkel Knut , Wollenberg Andreas , Effendy Isaak , Quist Sven , Asmussen Andrea , Wildberger Julia , Weisshaar Elke , Wiemers Franka , Brücher Jens‐Joachim , Weidinger Stephan , Schmitt Jochen , Werfel Thomas ,   die TREATgermany Study Group
Published: December 2023

ZusammenfassungHintergrundDas Eczema herpeticatum (EH) ist eine disseminierte Hautinfektion, die durch Herpes‐simplex‐Viren bei Patienten mit atopischer Dermatitis (AD) verursacht wird. Die Häufigkeit des EH und die klinischen Charakteristika von EH Patienten wurden bisher noch nicht in einer größeren Kohorte untersucht.Methodik87 Patienten des TREATgermany Registers, einem multizentrischen, nichtinterventionellen klinischen Register mit moderat bis schwer betroffenen AD‐Patienten in Deutschland, wurden in dieser Analyse betrachtet. Patienten, die zwischen Dezember 2017 und April 2021 in das Register eingeschlossen wurden, wurden unterteilt in die Gruppen ohne, mit einem und mit mehreren EH und basierend auf den klinischen Charakteristika verglichen.ErgebnisseVon 893 Patienten berichteten 195 (21,8%) über mindestens eine EH. 107 der 195 Patienten mit EH hatten sogar mehrere EH in der Anamnese (54,9%), was 12,0% der gesamten Studienpopulation entspricht. Während hinsichtlich demographischer Merkmale, Vorbehandlungen und Krankheitsscores (Juckreiz, IGA, oSCORAD, EASI) keine Unterschiede festgestellt wurden, litten Patienten mit EH häufiger an atopischen Begleiterkrankungen und Sensibilisierungen gegen Hausstaubmilben, Nahrungsmittel und Schimmelpilze.SchlussfolgerungenDie Daten des TREATgermany‐Registers deuten auf eine hohe Prävalenz und Rezidivrate des EH hin, während es neben einer Häufung von Allergien keinen spezifischen klinischen Phänotyp zu geben scheint, um EH‐Patienten in der täglichen Routine zu identifizieren.
Ganzkörper‐Blaulichtbestrahlung zur Behandlung der atopischen Dermatitis: eine randomisierte, placebokontrollierte klinische Studie (AD‐Blue)
Authors: Buhl Timo , Santibanez Santana Marisol , Forkel Susann , Kromer Christian , Seidel Julia , Möbs Christian , Pfützner Wolfgang , Pfeiffer Sebastian , Laubach Hans‐Joachim , Boehncke Wolf‐Henning , Liebmann Joerg , Born Matthias , Schön Michael Peter 
Published: December 2023

ZusammenfassungHintergrundSichtbares blaues Licht (Wellenlänge 400–495 nm) ist eine vielversprechende neue Behandlungsoption sowohl für Psoriasis als auch für atopische Dermatitis (AD). In früheren klinischen Studien wurden zwar verschiedene Geräte und blaues Licht mit unterschiedlichen Wellenlängen eingesetzt, aber keine dieser Prozeduren wurde anhand objektiver klinischer Kriterien geprüft.Patienten und Methodik87 Patienten mit AD wurden in die AD‐Blue‐Studie aufgenommen, eine internationale, prospektive, doppelblinde, dreiarmige (415 nm vs. 450 nm vs. Placebo), randomisierte Studie zur Untersuchung der Sicherheit und Wirksamkeit von Prototypen von Ganzkörper‐Blaulicht‐Bestrahlungsgeräten.ErgebnisseDie Ganzkörper‐Bestrahlung mit 450 nm blauem Licht, aber nicht mit 415 nm, hatte einen signifikant positiven Einfluss auf den Juckreiz (Pruritus‐VAS, –1,6 ± 2,3; p = 0,023 gegenüber der Placebobestrahlung). Die PO‐SCORAD‐Werte sanken ebenfalls signifikant als Reaktion auf die Bestrahlung bei 415 nm (–11,5 ± 18,4; p = 0,028 im Vergleich zur Placebobestrahlung). Keines der anderen Ergebnisse (EASI, SCORAD, IGA, DLQI) veränderte sich signifikant. Es wurden keine Sicherheitsprobleme beobachtet. Die Auswertung von Hauttranskriptomdaten, Zytokinspiegeln im Serum und ELISpots aus mononukleären Zellen des peripheren Blutes, die von einer Untergruppe von Patienten isoliert wurden, ergab eine moderate Abnahme von IL‐31 als Reaktion auf die Bestrahlung mit blauem Licht.SchlussfolgerungenTrotz des günstigen Sicherheitsprofils und der mäßigen Verringerung von Pruritus und IL‐31‐Spiegel führte die Ganzkörper‐Blaulichtbestrahlung bei AD zu keiner Verbesserung der objektiven Parameter zu Krankheitsschwere.
Citizen science data reveal altitudinal movement and seasonal ecosystem use by hummingbirds in the Andes Mountains
Authors: Rueda‐Uribe Cristina , Herrera‐Alsina Leonel , Lancaster Lesley T. , Capellini Isabella , Layton Kara K. S. , Travis Justin M. J. 
Published: December 2023

Ensuring connectivity is crucial to protect landscapes but it requires knowledge about how animals use ecosystems throughout the year. However, animal movements remain largely unknown in biodiversity hotspots, even for species that fulfill key ecological roles, as is the case of hummingbirds in the Andes. In the complex topography of mountain slopes, movement of these avian pollinators may occur either between habitat patches with asynchronous plant blooms or across ecosystems that are located within the same elevation bands or along altitudinal gradients. Here, we used two decades (2000–2020) of records from citizen science data and boosted regression trees to predict monthly distributions for 55 hummingbird species in the Andes. We identified shifts in altitudinal distribution between contiguous months and calculated changes in the proportion of predicted distributions occupied by ecosystem types. Our findings reveal substantial altitudinal movement and differences in the proportion of ecosystem types utilized throughout the year that had not been previously reported for several species. Yet the magnitude of altitudinal and ecosystem shifts varies between hummingbird clades, and in some cases changes in the proportion of ecosystem types within estimated distributions occurs with little variation in altitude. All ecosystems across the Andes show temporal changes in hummingbird occurrence, but these are higher in natural landscapes compared to croplands or urban areas. Finally, we used phylogenetic logistic regression to test whether altitudinal and ecosystem shifts affect population trends. We found that higher ecosystem seasonality is more strongly associated with decreasing populations in comparison to altitudinal shifts. Altogether, our study reveals complex patterns of movement in hummingbirds and highlights the importance of ecological connectivity across different ecosystem types. More generally, it demonstrates the opportunity of using citizen science data to increase understanding about species' seasonal occurrences, so that landscapes can be better managed to protect animal movement.Keywords: boosted regression trees, eBird, ecological connectivity, species distribution models
Limited impact of microtopography on alpine plant distribution
Authors: Chytrý Kryštof , Helm Norbert , Hülber Karl , Moser Dietmar , Wessely Johannes , Hausharter Johannes , Kollert Andreas , Mayr Andreas , Rutzinger Martin , Winkler Manuela , Pauli Harald , Saccone Patrick , Paetzolt Mariana , Hietz Peter , Dullinger Stefan 
Published: December 2023

Complex topography regulates near‐surface temperature above the treeline. It may thus sustain microrefugia for alpine plants and relax the need of shifting upward when the climate warms. The effectiveness of these microrefugia rests on the premise that plant distributions in alpine landscapes are mainly controlled by fine‐scale topographic variation.We tested this assumption by relating the distribution of 79 plant species and 10 community attributes across 900 1 m² plots in a landscape spanning 1677 m of elevation to 17 topographical descriptors at resolutions between 1 and 301 m.We found that the presence of most species and most community attributes were better explained by topographic variation at coarser scales (> 20 m). Fine‐scale topography is more clearly reflected in moisture than in temperature requirements of species. The elevational gradient rather than topographic variation at any scale, is the single most important driver of both species distributions and the variation in community attributes in the area studied.We hypothesise that our results reveal a hitherto underestimated influence of spatial mass effects on alpine plant distributions. These effects can override environmental filtering at fine scales and will thus impede the survival of cold‐adapted plants in small and fragmented refugia under climate warming.
First report of Scirtothrips dorsalis Hood in the Canary Islands
Authors: Mouratidis Angelos , Bastin Saskia , Pomposo Marta , Marrero Elías , Goldarazena Arturo , Hernández‐Suárez Estrella 
Published: December 2023

AbstractThe chilli thrips Scirtothrips dorsalis Hood (Thysanoptera: Thripidae) is an invasive polyphagous pest of several crops, and is native to South and East Asia. In recent decades, this thrips has successfully established in parts of the African and American continents. In the EPPO region its distribution is limited to Israel and Türkiye, and it is considered as under eradication in mainland Spain. This paper presents the first report of S. dorsalis on the island of Tenerife (Canary Islands, Spain), where individuals were initially found infesting mango in 2016, and subsequent inspections revealed infestations in 2022 that allowed its identification.