bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrasting Impacts of Agricultural Intensification and Urbanization on Lake Phosphorus Cycling and Implications for Managing Eutrophication
Authors: Slowinski Stephanie , Radosavljevic Jovana , Graham Alyssa , Ippolito Isabella , Thomas Kathryn , Rezanezhad Fereidoun , Shafii Mahyar , Parsons Chris T. , Basu Nandita B. , Wiklund Johan , Hall Roland I. , Van Cappellen Philippe 
Published: October 2023

AbstractSediment core and water quality data, together with historical information on land use/land cover (LULC), were used to reconstruct changes in phosphorus (P) loading and cycling in Lake Wilcox, Ontario, Canada, since the early 1920s. After first being cleared for farming, the originally forested watershed subsequently underwent urbanization. The large increase in P loading accompanying agricultural intensification after World War II caused the eutrophication of the lake. However, improved soil conservation since the 1980s and urban stormwater management since the 1990s have brought watershed P loading and sediment accumulation down to levels comparable to the early 1900s. Yet, the lake continues to exhibit eutrophication‐like symptoms, especially the intensification of hypoxia in the hypolimnion. Post‐2000 water quality data indicate that the latter is not driven by external P loading from the watershed, but rather by rapid salinization that strengthens the lake's summer stratification and enhances internal P loading. Salinization is caused by the increasing application of deicing agents in the expanding urban area. Curbing salt inputs will therefore be essential to restore the lake. Overall, our results provide new insights into the shifts in lake biogeochemistry associated with LULC changes and the implementation of best management practices. The approaches and findings of our case study have broad applicability for the large number of freshwater ecosystems worldwide that are experiencing salinization.
Nuclear exchange generates population diversity in the wheat leaf rust pathogen Puccinia triticina
Authors: Sperschneider Jana , Hewitt Tim , Lewis David C. , Periyannan Sambasivam , Milgate Andrew W. , Hickey Lee T. , Mago Rohit , Dodds Peter N. , Figueroa Melania 
Published: October 2023

AbstractIn clonally reproducing dikaryotic rust fungi, non-sexual processes such as somatic nuclear exchange are postulated to play a role in diversity but have been difficult to detect due to the lack of genome resolution between the two haploid nuclei. We examined three nuclear-phased genome assemblies of Puccinia triticina, which causes wheat leaf rust disease. We found that the most recently emerged Australian lineage was derived by nuclear exchange between two pre-existing lineages, which originated in Europe and North America. Haplotype-specific phylogenetic analysis reveals that repeated somatic exchange events have shuffled haploid nuclei between long-term clonal lineages, leading to a global P. triticina population representing different combinations of a limited number of haploid genomes. Thus, nuclear exchange seems to be the predominant mechanism generating diversity and the emergence of new strains in this otherwise clonal pathogen. Such genomics-accelerated surveillance of pathogen evolution paves the way for more accurate global disease monitoring.
Comparison of delayed bleeding to immediate bleeding following thyroidectomy
Authors: Lee Jun Sung , Lee Jin Seok , Yun Hyeok Jun , Chang Hojin , Kim Seok-Mo , Lee Yong Sang , Chang Hang-Seok 
Published: October 2023

AbstractIt is important to identify risk factors for post-thyroidectomy bleeding requiring airway intervention or reoperation. Therefore, we aimed to compare the characteristics of patients with postoperative bleeding after thyroid surgery according to the period until reoperation. We conducted a retrospective study analyzing data between April 2009 and July 2022 and included 126 patients who had postoperative bleeding. The patients were grouped according to the period between thyroidectomy and reoperation due to bleeding (0 day, 1–7 days, > 7 days). We performed among-group comparisons of patient characteristics and surgical aspects, including the extent of surgery. The ratios of male–female and lateral neck dissection were higher in the post-operative bleeding group than in the group without bleeding. In the analysis of patients with postoperative bleeding, grouped according to period between thyroidectomy and reoperation, there was a significant among-group difference in the male–female ratio. The male sex was positively correlated with the reoperation period. Further, the reoperation period was also positively correlated with total thyroidectomy and lateral neck dissection and the operation time showed a significant among-group difference. Our results indicate that the male sex and lateral neck dissection are risk factors for postoperative bleeding after thyroidectomy. Furthermore, male sex, total thyroidectomy, and lateral neck dissection are risk factors for delayed bleeding. Therefore, clinicians should consider these factors for interventions against immediate or delayed bleeding after thyroidectomy.
Perceptions of sexism interact with perceived criticism on women’s response to sexist remarks in different relationship types
Authors: Neoh Michelle Jin Yee , Teng Jia Hui , Setoh Peipei , Esposito Gianluca 
Published: October 2023

AbstractSexism is a widespread form of gender discrimination, which can take the form of criticism towards women based on gender stereotypes. However, little is known about how perceived criticism and sexism shape one’s construal of criticism from various interpersonal sources. The present study investigated whether perceived criticism, perceived sexism and the source of criticism (mother, father, workplace supervisor, romantic partner) interact to influence upset levels in response to criticism. 178 participants completed perceived criticism (PC) ratings for the four relationships and 95 female participants also completed the Schedule of Sexist Events scale. Participants read experimental vignettes describing scenarios of criticism from different sources and rated how upset they would feel in each scenario. Perceived sexism significantly moderated the effect of PC on upset levels only for sexist-related criticism from romantic partners and supervisors. Female participants with low perceived sexism show higher levels of upset as PC increased for sexist-related criticism from supervisors whereas female participants with high perceived sexism show lower levels of upset as PC increased for sexist-related criticism from romantic partners. These findings contribute towards understanding how perceived criticism and perceived sexism influence affective reactions to criticism across interpersonal sources.
Risk factors for discontinuation of intravenous patient-controlled analgesia after general surgery: a retrospective cohort study
Authors: Kim Saeyeon , Song In-Ae , Lee Boram , Oh Tak Kyu 
Published: October 2023

AbstractIdentifying patients at risk for developing side effects secondary to intravenous patient-controlled analgesia (IV PCA) and making the necessary adjustments in pain management are crucial. We investigated the risk factors of discontinuing IV PCA due to side effects following general surgery; adult patients who received IV PCA after general surgery (2020–2022) were included. Data on postoperative pain intensity, PCA pain relief, side effects, continuity of PCA use, and PCA pump settings were collected from the records of the acute pain management team. The primary outcome was identifying the risk factors associated with PCA discontinuation due to side effects. Of the 8745 patients included, 94.95% used opioid-containing PCA, and 5.05% used non-steroidal anti-inflammatory drug (NSAID)-only PCA; 600 patients discontinued PCA due to side effects. Female sex (adjusted odds ratio [aOR] 3.31, 95% confidence interval [CI] 2.74–4.01), hepato-pancreatic-biliary surgery (aOR 1.43, 95% CI 1.06–1.94) and background infusion of PCA (aOR 1.42, 95% CI 1.04, 1.94) were associated with an increased likelihood of PCA discontinuation. Preoperative opioid use (aOR 0.49, 95% CI 0.28–0.85) was linked with a decreased likelihood of PCA discontinuation. These findings highlight the importance of individualized pain management, considering patient characteristics and surgical procedures.
Novel study on enhancing the ignition pattern of waste and inedible feedstock in a modified diesel engine-enhancing its effectiveness as renewable alternative
Authors: Rajesh K. , Bibin Chidambaranathan , Natarajan M. P. , Ponnuvel S. , Devarajan Yuvarajan , Raja T. , Kaliappan Nandagopal 
Published: October 2023

AbstractThe objective of the present investigation is to enhance the performance of diesel engine using Capparis spinoza fatty acid distillate biodiesel (CFAB100) at various compression ratios. The experiments were carried out at compression ratios of 16.5:1, 17.5:1, 18.5:1, and 19.5:1. It was noted that an increase in compression ratio from 16.5 to 18.5 resulted in better engine characteristics for CFAB100 and reduced at compression ratio 19.5. Brake-specific fuel consumption of CFAB100 decreased from 0.42 to 0.33 kg/kWh with an increase in compression ratio. The brake thermal efficiency of CFAB100 at a compression ratio of 16.5 is 29.64% lower than diesel, whereas it is 11.32% low at a compression ratio of 18.5. The brake thermal efficiency of CFAB100 is 26.03% higher at a compression ratio of 18.5 compared to 16.5. Due to shorter ignition delay and reduced premixed combustion, the net heat release rate of CFAB100 is lower than diesel at all compression ratios. The peak cylinder pressure for diesel is 56.21 bar, and CFAB100 at compression ratios 16.5, 17.5, 18.5, and 19.5 were 52.36, 55.12, 61.02 and 58.25 bar at full load condition. CFAB100, at a compression ratio of 18.5, had the highest nitrogen oxide emissions (2400 ppm). Carbon monoxide, unburnt hydrocarbon, and smoke showed an average reduction of 46.58%, 40.68%, and 54.89%, respectively, when the compression ratio varied between 16.5 and 19.5. At an optimum compression ratio of 18.5, the CFAB100 resulted in improved performance and emission characteristics that can replace diesel to a possible extent.
BDNF-TrkB/proBDNF-p75NTR pathway regulation by lipid emulsion rescues bupivacaine-induced central neurotoxicity in rats
Authors: Jia Danting , Wang Fang , Bai Zhixia , Chen Xuexin 
Published: October 2023

AbstractBupivacaine (BPV) can cause severe central nervous system toxicity when absorbed into the blood circulation system. Rapid intravenous administration of lipid emulsion (LE) could be used to treat local anaesthetic toxicity. This study aimed to investigate the mechanism by which the BDNF-TrkB/proBDNF-p75NTR pathway regulation by LE rescues BPV induced neurotoxicity in hippocampal neurons in rats. Seven- to nine-day-old primary cultured hippocampal neurons were randomly divided into 6 groups: the blank control group (Ctrl), the bupivacaine group (BPV), the lipid emulsion group (LE), the bupivacaine + lipid emulsion group (BPV + LE), the bupivacaine + lipid emulsion + tyrosine kinase receptor B (TrkB) inhibitor group (BPV + LE + K252a), the bupivacaine + lipid emulsion + p75 neurotrophic factor receptor (p75NTR) inhibitor group (BPV + LE + TAT-Pep5). All hippocampal neurons were incubated for 24 h, and their growth state was observed by light microscopy. The relative TrkB and p75NTR mRNA levels were detected by real-time PCR. The protein expression levels of brain-derived neurotrophic factor (BDNF), proBDNF, TrkB, p75NTR and cleaved caspase-3 were detected by western blotting. The results showed that primary hippocampal neuron activity was reduced by BPV. As administration of LE elevated hippocampal neuronal activity, morphology was also somewhat improved. The protein expression and mRNA levels of TrkB and p75NTR were decreased when BPV induced hippocampal neuronal toxicity, while the expression of BDNF was increased. At the same time, BPV increased the original generation of cleaved caspase-3 protein content by hippocampal neurons, while the content of cleaved caspase-3 protein in hippocampal neurons cotreated with LE and BPV was decreased. Thus, this study has revealed LE may reduce apoptosis and promote survival of hippocampal neurons by regulating the BDNF-TrkB pathway and the proBDNF-p75NTR pathway to rescue BPV induced central neurotoxicity in rats.
The safety and effectiveness of clopidogrel versus aspirin in Kawasaki disease with mild-to-moderate liver injury
Authors: Gao Lichao , Wang Wei , Wang Huafeng , Xu Zhufei , Zhou Shulai , Geng Zhimin , Fu Songling , Xie Chunhong , Zhang Yiying , Wang Yujia , Gong Fangqi 
Published: October 2023

AbstractKawasaki disease can be combined with liver injury. As a mainstay treatment for Kawasaki disease, aspirin may cause liver injury. This study aimed to compare the safety and effectiveness of clopidogrel versus aspirin in Kawasaki disease with mild-to-moderate liver injury. This study retrospectively analysed 166 children with Kawasaki disease combined with mild-to-moderate liver injury. The children treated with clopidogrel were less likely to have aggravated liver injury than those treated with aspirin (n = 2/100 vs. n = 13/66, P < 0.001). The initial alanine aminotransferase value of the clopidogrel group was higher (131.5 [98.5, 167.5] vs. 96 [72, 133], P < 0.001), while the time of alanine aminotransferase recovery to normal was similar (5 [4, 7] vs. 4 [3, 7], P = 0.179). No significant fever differences observed between groups: 7.5 [6, 9] for aspirin vs. 7 [6, 8] for clopidogrel group, P = 0.064. The probability of nonresponse to intravenous immunoglobulin (n = 29/100 vs. n = 30/66, P = 0.030) and the days of hospitalization (n = 6 [4, 9] vs. n = 7 [5, 10], P = 0.007) in the clopidogrel group were less than those in the aspirin group. In conclusion, the application of clopidogrel is potentially superior to aspirin in Kawasaki disease combined with mild-to-moderate liver injury.
Anti-SARS-CoV-2 antibody levels predict outcome in COVID-19 patients with type 2 diabetes: a prospective cohort study
Authors: Mink Sylvia , Saely Christoph H. , Leiherer Andreas , Frick Matthias , Plattner Thomas , Drexel Heinz , Fraunberger Peter 
Published: October 2023

AbstractPatients with type 2 diabetes (T2D) constitute one of the most vulnerable subgroups in COVID-19. Despite high vaccination rates, a correlate of protection to advise vaccination strategies for novel SARS-CoV-2 variants of concern and lower mortality in this high-risk group is still missing. It is further unclear what antibody levels provide protection and whether pre-existing organ damage affects this threshold. To address these gaps, we conducted a prospective multicenter cohort study on 1152 patients with COVID-19 from five hospitals. Patients were classified by diabetes and vaccination status. Anti-SARS-CoV-2-spike-antibodies, creatinine and NTproBNP were measured on hospital admission. Pre-specified endpoints were all-cause in-hospital-mortality, ICU admission, endotracheal intubation, and oxygen administration. Propensity score matching was applied to increase comparability. We observed significantly lower anti-SARS-CoV-2-spike-antibodies in diabetic non-survivors compared to survivors (mean, 95% CI 351BAU/ml, 106–595 vs. 1123, 968–1279, p < 0.001). Mortality risk increased two-fold with each standard deviation-decrease of antibody levels (aHR 1.988, 95% CI 1.229–3.215, p = 0.005). T2D patients requiring oxygen administration, endotracheal intubation and ICU admission had significantly lower antibody levels than those who did not (p < 0.001, p = 0.046, p = 0.011). While T2D patients had significantly worse outcomes than non-diabetic patients, the differences were less pronounced compared to propensity-score-matched non-diabetic patients. Anti-SARS-CoV-2 spike antibodies on hospital admission are inversely associated with oxygen administration, endotracheal intubation, intensive care and in-hospital mortality in diabetic COVID-19 patients. Pre-existing comorbidities may have a greater impact on outcome than diabetes status alone.
Radio outburst from a massive (proto)star
Authors: Cesaroni R. , Moscadelli L. , Caratti o Garatti A. , Eislöffel J. , Fedriani R. , Neri R. , Ray T. , Sanna A. , Stecklum B. 
Published: October 2023

Context. Growing observational evidence indicates that the accretion process leading to star formation may occur in an episodic way, through accretion outbursts revealed in various tracers. This phenomenon has also now been detected in association with a few young massive (proto)stars (>8 M⊙), where an increase in the emission has been observed from the IR to the centimetre domain. In particular, the recent outburst at radio wavelengths of S255IR NIRS 3 has been interpreted as due to the expansion of a thermal jet, fed by part of the infalling material, a fraction of which has been converted into an outflow.
Aims. We wish to follow up on our previous study of the centimetre and millimetre continuum emission from the outbursting massive (proto)star S255IR NIRS 3 and confirm our interpretation of the radio outburst, based on an expanding thermal jet.
Methods. The source was monitored for more than 1 yr in six bands from 1.5 GHz to 45.5 GHz with the Karl G. Jansky Very Large Array, and, after an interval of ~1.5 yr, it was imaged with the Atacama Large Millimeter/submillimeter Array at two epochs, which made it possible to detect the proper motions of the jet lobes.
Results. The prediction of our previous study is confirmed by the new results. The radio jet is found to expand, while the flux, after an initial exponential increase, appears to stabilise and eventually decline, albeit very slowly. The radio flux measured during our monitoring is attributed to a single lobe, expanding towards the NE. However, starting from 2019, a second lobe has been emerging in the opposite direction, probably powered by the same accretion outburst as the NE lobe, although with a delay of at least a couple of years. Flux densities measured at frequencies higher than 6 GHz were satisfactorily fitted with a jet model, whereas those below 6 GHz are clearly underestimated by the model. This indicates that non-thermal emission becomes dominant at long wavelengths.
Conclusions. Our results suggest that thermal jets can be a direct consequence of accretion events, when yearly flux variations are detected. The formation of a jet lobe and its early expansion appear to have been triggered by the accretion event that started in 2015. The end of the accretion outburst is also mirrored in the radio jet. In fact, ~1 yr after the onset of the radio outburst, the inner radius of the jet began to increase, at the same time the jet mass stopped growing, as expected if the powering mechanism of the jet is quenched. We conclude that our findings strongly support a tight connection between accretion and ejection in massive stars, consistent with a formation process involving a disk-jet system similar to that of low-mass stars.
Elementary school teachers’ attitudes towards project-based learning in China
Authors: Cai Zhiling , Zhu Jinxing , Yu Yu , Tian Saiqi 
Published: October 2023

AbstractThis study analyzed the Chinese elementary school teachers’ attitudes toward project-based learning (PBL) and identified factors that may influence elementary school teachers’ attitudes. The analysis was based on a questionnaire survey of 257 elementary school teachers and interviews with 10 elementary school teachers in China. Results showed that Chinese elementary school teachers generally had positive attitudes towards PBL, but their attitudes differed based on their educational level, years of teaching, and subjects taught. Results of the regression analysis found that training, social support, resources, and availability of time all positively influenced teachers’ attitudes toward PBL. Finally, the interview data were analyzed to understand teachers’ perceptions of how they could be helped to use PBL in teaching.
The impact of perceived organizational support on employees’ knowledge transfer and innovative behavior: comparisons between Taiwan and mainland China
Authors: Peng Michael Yao-Ping , Xu Cheng , Zheng Rong , He Yuan 
Published: October 2023

AbstractThis study investigates the correlations among perceived organizational support (POS), self-efficacy, knowledge transfer, and innovative behaviors of employees in the information service companies of Taiwan and mainland China using goal-oriented behavior and social identity theory. A structural model was built, and data were collected through a survey conducted in two rounds, two months apart, during the COVID-19 pandemic. The results indicate that POS significantly affects innovation behavior and self-efficacy in both regions, and self-efficacy plays a key mediating role in the research model. However, the relationship between POS and knowledge transfer was non-significant for mainland China. The study also reveals that the culture of knowledge sharing in the organization can promote employees’ innovation, knowledge sharing behavior, communication, and knowledge transfer. The findings imply that managers should provide organizational support to improve employees’ innovative minds and self-belief, particularly during the pandemic. This research fills a theoretical gap by applying Western theories in an Eastern context and broadening the generalization of the theory. It provides practical implications for improving the quality of human resources by suggesting that managers should provide organizational support to improve employees’ innovative minds and self-belief, particularly during a pandemic. Additionally, it contributes to the literature by examining how cross-cultural differences affect the relationships among POS, self-efficacy, knowledge transfer, and innovative behavior. This study also enriches the literature about employees in particular regions and their service innovation behaviors.
Developmental trajectories of depression, anxiety, and stress among college students: a piecewise growth mixture model analysis
Authors: Liu Xinqiao , Zhang Yifan , Gao Wenjuan , Cao Xiaojie 
Published: October 2023

AbstractMental health issues are becoming increasingly common among college students, but not all students follow the same developmental trends of mental health. This study aims to identify the developmental trajectories of depression, anxiety, and stress among college students and the related factors for different trajectory classes. The data were collected from a longitudinal survey of college students over four consecutive years, and 2473 students were included in the analysis. The study used a piecewise growth mixture model to determine the subtrajectories, and a multinomial logistic regression model was constructed to investigate the related factors affecting students in subtrajectories. The results revealed that subtrajectories include the low and stable class, increasing class, decreasing then stable class, increasing then decreasing class, and decreasing and high class. The decreasing and high class only presents in the trajectories of anxiety and stress. Regarding related factors, high BMI and high sleep hours were identified as related factors for the increasing class of depression; gender and high sleep hours were associated with the increasing class of anxiety; and hometown location was related to the increasing class of stress. Extroversion personality, relationship with classmates, siblings, and father’s education level are related factors for other subtrajectories. Considering that college students experience multiple trajectories of depression, anxiety, and stress, mental health education and psychological intervention should be carried out for students in each class.