bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editorial: The evolving paradigms and treatments for primary biliary cholangitis
Authors: Vuppalanchi Raj , Kowdley Kris V. 
Published: December 2023

LINKED CONTENTThis article is linked to Mayo et al papers. To view these articles, visit https://doi.org/10.1111/apt.17755 and https://doi.org/10.1111/apt.17798
Editorial: The evolving paradigms and treatments for primary biliary cholangitis—Authors' reply
Authors: Mayo Marlyn J. , Vierling John M. , Bowlus Christopher L. 
Published: December 2023

LINKED CONTENTThis article is linked to Mayo et al papers. To view these articles, visit https://doi.org/10.1111/apt.17755 and https://doi.org/10.1111/apt.17779
Letter: interpretation of the BESST trial in the context of baseline antidepressant and neuromodulator use
Authors: Hiramoto Brent , Chan Walter W. 
Published: December 2023

LINKED CONTENTThis article is linked to Parkman et al papers. To view these articles, visit https://doi.org/10.1111/apt.17479 and https://doi.org/10.1111/apt.17838
Editorial: Does knowledge about liver disease enhance adherence to lifestyle recommendations? Authors' reply
Authors: Petroni Maria Letizia , Colosimo Santo , Marchesini Giulio 
Published: December 2023

LINKED CONTENTThis article is linked to Petroni et al papers. To view these articles, visit https://doi.org/10.1111/apt.17768 and https://doi.org/10.1111/apt.17789
A newly developed surgeon‐controlled suction device in robotic‐assisted thoracoscopic surgery
Authors: Nakagawa Tatsuo , Murakami Hiroaki , Ohsumi Yuki , Miyamoto Ei , Gotoh Masashi 
Published: December 2023

AbstractIntroductionAssistant surgeons usually clean the surgical field with a suction cannula in robotic‐assisted surgery. This manipulation requires skill and experience to avoid interfering with the operation of the console surgeon. Recently, we created a new suction device that a console surgeon can manipulate with the robotic arms.Materials and Surgical TechniqueA small metal suction tip with as a lumen and small side pores for suction and can be connected to a silicone tube connected to wall suction. The tip of the silicone tube can be grasped with robotic forceps and used for organ retraction as well as suction. The suction device has been used in eight lung lobectomy cases and four lung segmentectomy cases to date. There were no major difficulties related to the new suction device except for metal tip disconnection and blood clots clogging.DiscussionOur newly developed surgeon‐controlled suction device is inexpensive, easy to handle, and useful for suction, blunt dissection, and organ retraction in robotic‐assisted thoracoscopic surgery, especially when performing lymph node dissection.
Global standards and the philosophy of consumption: Toward a consumer‐driven governance of global value chains
Authors: Karimova Guli‐Sanam , Heidbrink Ludger , Brinkmann Johannes , LeMay Stephen Arthur 
Published: December 2023

AbstractThis study delves into the significant ethical criteria in the context of global standards. It addresses the moral wrongdoings and adverse side effects associated with global value chains as discussed in the business ethics literature. The methodology involves theoretical application and synthesis. The study employs ethical principles from deontology, consequentialism, and political cosmopolitanism to establish normative criteria such as “injustice and harm to others” and “bad outcomes.” It further investigates how these criteria should influence consumers' decisions, actions, and responsibilities. These criteria are then used to examine the moral wrongdoings and negative effects mentioned in global standards. The study explores how global standards implicitly express consumers' roles in governing global value chains. It scrutinizes consumers' actions and decisions by applying ethical frameworks to global standards. The study outlines consumers' individual and political responsibilities in achieving the goals of global standards. The research findings have implications for governments, consumers, and organizations in practicing shared responsibility. The aim of this research is to provide normative guidance for responsible actions.
Enhancing early language and literacy skills for racial/ethnic minority children with low incomes through a randomized clinical trial: The mediating role of cognitively stimulating parent–child interactions
Authors: Miller Elizabeth B. , Canfield Caitlin F. , Roby Erin , Wippick Helena , Shaw Daniel S. , Mendelsohn Alan L. , Morris‐Perez Pamela A. 
Published: December 2023

AbstractParenting is a critical mediator of children's school readiness. In line with this theory of change, data from the randomized clinical trial of Smart Beginnings (tiered Video Interaction Project and Family Check‐Up; N = 403, treatment arm n = 201) were used to examine treatment impacts on early language and literacy skills at child age 4 years (nLatinx = 168, nBlack = 198, nMale = 203), as well as indirect impacts through parental support of cognitive stimulation at child age 2 years. Although results did not reveal direct effects on children's early skills, there were significant indirect effects for early literacy (β = .03, p = .05) and early language (β = .04, p = .04) via improvements in parental cognitive stimulation. Implications for interventions targeting parenting to improve children's school readiness beginning at birth are discussed.
SAM domain variants of EPHB4 associated with aberrant signaling are linked to lymphatic‐related fetal hydrops and facial dysmorphology
Authors: Vanden Broek Kara , Ryu Jae‐Ryeon , Perrier Renee , Tyndall Amanda V. , Childs Sarah J. , Au Ping Yee Billie 
Published: December 2023

AbstractVariants in EPHB4 (Ephrin type B receptor 4), a transmembrane tyrosine kinase receptor, have been identified in individuals with various vascular anomalies including Capillary Malformation‐Arteriovenous Malformation syndrome 2 and lymphatic‐related (non‐immune) fetal hydrops (LRHF). Here, we identify two novel variants in EPHB4 that disrupt the SAM domain in two unrelated individuals. Proband 1 presented within the LRHF phenotypic spectrum with hydrops, and proband 2 presented with large nuchal translucency prenatally that spontaneously resolved in addition to dysmorphic features on exam postnatally. These are the first disease associated variants identified that do not disrupt EPHB4 protein expression or tyrosine‐kinase activity. We identify that EPHB4 SAM domain disruptions can lead to aberrant downstream signaling, with a loss of the SAM domain resulting in elevated MAPK signaling in proband 1, and a missense variant within the SAM domain resulting in increased cell proliferation in proband 2. This data highlights that a functional SAM domain is required for proper EPHB4 function and vascular development.
Are child custody evaluations beneficial to family law judges? A study from the judicial perspective
Authors: Axelson Tammi , Gentile Jennifer 
Published: December 2023

AbstractThere is a long history of dissension among legal and mental health professionals about the value of child custody evaluations. Despite frequent use by the courts, the lack of adequate empirical research impedes the ability to validate the efficacy of child custody evaluations. This study investigated the overall value of court‐ordered child custody evaluations by surveying a diverse, national sample of judges to gather data regarding the usefulness, and validity of child custody evaluations. Two hundred and sixty‐eight judges from 42 states completed an anonymous survey. The results indicated that judges find information voiced by the child in question, data obtained from the parent–child observations, and collateral data obtained about the litigants as most useful. Survey findings suggested judges perceived there to be a shortage of trained evaluators and also consider child custody evaluations too expensive and too time‐consuming. Overall, judges find child custody evaluations useful and clearly desire experts to include recommendations on legal custody and parenting time schedules in their reports.
Rock magnetic analyses as a tool to investigate diversity of drift pumice clasts: An example from Japan's 2021 Fukutoku‐Oka‐no‐Ba (FOB) eruption
Authors: Carlut Julie , Isambert Aude , Carvallo Claire , Garcia da Fonseca Geoffrey , Moussissa Nelly‐Wangue , Bouis Arthur , Yoshida Kenta 
Published: December 2023

AbstractThe crystallization of nanolites within magma chambers has recently raised a strong interest due to their impact on increasing melt viscosity and triggering magmatic eruptions. In 2021, the Fukutoku‐Oka‐no‐Ba (FOB) underwater eruption produced large quantities of pumices that eventually formed rafts drifting at the surface of the ocean to the East coasts of Japan. Pumices collected along the shore shortly after grounding show various colors, microscopic and Raman analyses made by Yoshida et al. (Island Arc, 31, 1, 2022) revealed the presence of magnetite nanolites in some of them. In this study, we explore the magnetic properties of a batch of pumices of different colors from the FOB eruption, aiming to refine characterization of iron oxide nanolites. We used various analytical techniques such as SEM and FEG‐SEM observations, EDS‐X analyses, and rock magnetic experiments, including thermomagnetic analyses, hysteresis curves, coercivity analyses and FORC measurements. Our findings reveal that the iron oxides present in the FOB samples are Ti‐magnetite, with minor amounts of Mg and Al. The magnetic crystals show a wide range of sizes, from extra small iron oxide nanolites (ESION) in the pumices with the lighter colors, to more bulky grains reaching the micrometer size in some of the dark color samples, significant diffusion is inferred in that case. Consequently, the magnetic characterization of iron oxide crystals within the Fukutoku‐Oka‐no‐Ba pumices reveals varying stages of nucleation, dissolution, growth, and diffusion processes, providing evidences for the heterogeneous state of the magma during the eruption.
Pharmacogenetic biomarkers for secukinumab response in psoriasis patients in real‐life clinical practice
Authors: Muñoz‐Aceituno E. , Butrón‐Bris B. , Ovejero‐Benito M. C. , Sahuquillo‐Torralba A. , Baniandrés Rodríguez O. , Herrera‐Acosta E. , Rivera‐Diaz R. , Ferran M. , Sánchez‐Carazo J. L. , Riera‐Monroig J. , Pujol‐Montcusí J. , Vidal D. , de la Cueva P. , García‐Bustinduy M. , Ruiz‐Villaverde R. , Ballescà F. , Llamas‐Velasco M. , Navares M. , Palomar‐Moreno I. , Sánchez‐García I. , García‐Martínez J. , Novalbos J. , Zubiaur P. , Abad‐Santos F. , Daudén‐Tello E. , de la Fuente H. 
Published: December 2023

AbstractBackgroundPrediction of the response to a biological treatment in psoriasis patients would allow efficient treatment allocation.ObjectiveTo identify polymorphisms associated with secukinumab response in psoriasis patients in a daily practice setting.MethodsWe studied 180 SNPs in patients with moderate‐to‐severe plaque psoriasis recruited from 15 Spanish hospitals. Treatment effectiveness was evaluated by absolute PASI ≤3 and ≤1 at 6 and 12 months. Individuals were genotyped using a custom Taqman array. Multiple logistic regression models were generated. Sensitivity, specificity and area under the curve (AUC) were analysed.ResultsA total of 173 patients were studied at 6 months, (67% achieved absolute PASI ≤ 3 and 65% PASI ≤ 1) and 162 at 12 months (75% achieved absolute PASI ≤ 3 and 64% PASI ≤ 1). Multivariable analysis showed the association of different sets of SNPs with the response to secukinumab. The model of absolute PASI≤3 at 6 months showed best values of sensitivity and specificity. Four SNPs were associated with the capability of achieving absolute PASI ≤ 3 at 6 months. rs1801274 (FCGR2A), rs2431697 (miR‐146a) and rs10484554 (HLCw6) were identified as risk factors for failure to achieve absolute PASI≤3, while rs1051738 (PDE4A) was protective. AUC including these genotypes, weight of patients and history of biological therapy was 0.88 (95% CI 0.83–0.94), with a sensitivity of 48.6% and specificity of 95.7% to discriminate between both phenotypes.ConclusionWe have identified a series of polymorphisms associated with the response to secukinumab capable of predicting the potential response/non‐response to this drug in patients with plaque psoriasis.
Strategies to combat heat stress in poultry production—A review
Authors: Mangan Modou , Siwek Maria 
Published: December 2023

AbstractThe effects of heat stress (HS) caused by high temperatures continue to be a global concern in poultry production. Poultry birds are homoeothermic, however, modern‐day chickens are highly susceptible to HS due to their inefficiency in dissipating heat from their body due to the lack of sweat glands. During HS, the heat load is higher than the chickens' ability to regulate it. This can disturb normal physiological functioning, affect metabolism and cause behavioural changes, respiratory alkalosis and immune dysregulation in birds. These adverse effects cause gut dysbiosis and, therefore, reduce nutrient absorption and energy metabolism. This consequently reduces production performances and causes economic losses. Several strategies have been explored to combat the effects of HS. These include environmentally controlled houses, provision of clean cold water, low stocking density, supplementation of appropriate feed additives, dual and restricted feeding regimes, early heat conditioning and genetic selection of poultry lines to produce heat‐resistant birds. Despite all these efforts, HS still remains a challenge in the poultry sector. Therefore, there is a need to explore effective strategies to address this long‐lasting problem. The most recent strategy to ameliorate HS in poultry is early perinatal programming using the in ovo technology. Such an approach seems particularly justified in broilers because chick embryo development (21 days) equals half of the chickens' posthatch lifespan (42 days). As such, this strategy is expected to be more efficient and cost‐effective to mitigate the effects of HS on poultry and improve the performance and health of birds. Therefore, this review discusses the impact of HS on poultry, the advantages and limitations of the different strategies. Finally recommend a promising strategy that could be efficient in ameliorating the adverse effects of HS in poultry.
Introgression of a dominant phototropin1 mutant enhances carotenoids and boosts flavour‐related volatiles in genome‐edited tomato RIN mutants
Authors: Nizampatnam Narasimha Rao , Sharma Kapil , Gupta Prateek , Pamei Injangbuanang , Sarma Supriya , Sreelakshmi Yellamaraju , Sharma Rameshwar 
Published: December 2023

Summary

The tomato (Solanum lycopersicum) ripening inhibitor (rin) mutation is known to completely repress fruit ripening. The heterozygous (RIN/rin) fruits have extended shelf life, ripen normally, but have inferior taste/flavour. To address this, we used genome editing to generate newer alleles of RIN (rinCR) by targeting the K‐domain.

Unlike previously reported CRISPR alleles, the rinCR alleles displayed delayed onset of ripening, suggesting that the mutated K‐domain represses the onset of ripening. The rinCR fruits had extended shelf life and accumulated carotenoids at an intermediate level between rin and progenitor line. Besides, the metabolites and hormonal levels in rinCR fruits were more akin to rin.

To overcome the negative attributes of rin, we crossed the rinCR alleles with Nps1, a dominant‐negative phototropin1 mutant, which enhances carotenoid levels in tomato fruits. The resulting Nps1/rinCR hybrids had extended shelf life and 4.4–7.1‐fold higher carotenoid levels than the wild‐type parent.

The metabolome of Nps1/rinCR fruits revealed higher sucrose, malate, and volatiles associated with tomato taste and flavour. Notably, the boosted volatiles in Nps1/rinCR were only observed in fruits bearing the homozygous Nps1 mutation. The Nps1 introgression into tomato provides a promising strategy for developing cultivars with extended shelf life, improved taste, and flavour.
Clinical, histological, and molecular differences in melanoma due to different TERT promoter mutations subtypes. A retrospective cross‐sectional study in 684 melanoma patients
Authors: Manrique‐Silva Esperanza , David Millán‐Esteban , Maider Aguerralde‐Martin , García‐Casado Zaida , Moro Ruggero , Requena Celia , Través Victor , Virós Amaya , Kumar Rajiv , Nagore Eduardo 
Published: December 2023

AbstractDifferences in survival according to the pTERT mutation subtypes (−124C > T, −146C > T, and tandem −138_139CC > TT) have been observed. The present study aimed to describe the clinical as the histopathological and molecular cutaneous melanoma features according to the presence of the three most prevalent pTERT mutation subtypes (−124C > T, −146C > T, and tandem −138_139CC > TT). A retrospective cross‐sectional study including 684 patients was designed, and a Partial Least‐Squares Discriminant Analysis (PLS‐DA) was performed. After the PSL‐DA, it was observed that the tandem −138_139CC > TT subtype differs from the other subtypes. The model demonstrated that the −124C > T and the −138_139 CC > TT subtypes were associated with fast‐growing melanomas (OR 0.5, CI 0.29–0.86, p = .012) and with Breslow >2 mm (OR 0.6, CI 0.37–0.97, p = .037), compared to the −146C > T mutation. Finally, the −124C > T appeared to be more associated with the presence of TILs (non‐brisk) than the −146C > T (OR 0.6, CI 0.40–1.01, p = .05). These findings confirmed that the −124C > T and the tandem −138_139 CC > TT subtypes are both highly associated with the presence of features of aggressiveness; however, only the −124C > T was highly associated with TILs. This difference could explain the worse survival rate associated with the tandem −138_139CC > TT mutations.
Growth and photosynthetic physiology of holopelagic Sargassum (Phaeophyceae) under laboratory conditions
Authors: Vásquez‐Elizondo Román Manuel , Vázquez‐Delfín Erika , Robledo Daniel 
Published: December 2023

SummarySpecies of holopelagic Sargassum are responsible for Caribbean golden tides, commonly known as ‘Sargassum events’. These events mainly comprise Sargassum fluitans and Sargassum natans I, which are exposed to high levels of irradiance, but also self‐shading within their floating masses. In this study, we grew S. fluitans and S. natans I and acclimated them to low‐light conditions at 23°C in the laboratory to explore their responses to increasing light intensities. Photosynthesis, respiration, growth, and pigment content were evaluated over 3 weeks. S. fluitans and S. natans I photoacclimate to higher irradiances by decreasing their chlorophyll a and c contents. An increase in maximum photosynthesis and respiration rates was observed under high light, although differences occurred in the saturation irradiance and the initial slope of the photosynthesis versus irradiance curve. These adjustments were reflected in S. fluitans daily growth (from 2% to 7% d−1 at low to high light, respectively) and tissue nitrogen content (1.6–2.7%) but were absent in S. natans I (~1% d−1). The photosynthetic physiology of S. fluitans under these conditions suggests lower light requirements without compromising growth; however, under high light a higher photosynthetic performance was observed. Combining physiological and growth studies in holopelagic Sargassum species will serve as a baseline to understand and explain the success and overgrowth of these species along the Caribbean coast.
Utility of the Japanese version of the Clinical Dementia Rating® plus National Alzheimer's Coordinating Centre Behaviour and Language Domains for sporadic cases of frontotemporal dementia in Japan
Authors: Taomoto Daiki , Sato Shunsuke , Kanemoto Hideki , Suzuki Maki , Hirakawa Natsuho , Takasaki Akihiro , Akimoto Miu , Satake Yuto , Koizumi Fuyuki , Yoshiyama Kenji , Takahashi Rei , Shigenobu Kazue , Hashimoto Mamoru , Miyagawa Toji , Boeve Bradley , Knopman David , Mori Etsuro , Ikeda Manabu 
Published: December 2023

AbstractBackgroundWe aimed to validate the Clinical Dementia Rating (CDR®) dementia staging instrument plus the National Alzheimer's Coordinating Centre Behaviour and Language Domains (CDR® plus NACC FTLD) for use in clinical settings in Japan and in the Japanese language.MethodsThis prospective observational study enrolled 29 patients with frontotemporal dementia (FTD) and 21 patients with Alzheimer's disease (AD) dementia from the Departments of Psychiatry at Osaka University Hospital and Asakayama General Hospital and the Brain Function Centre at Nippon Life Hospital. CDR® plus NACC FTLD, CDR®, Mini‐Mental State Examination (MMSE), Western Aphasia Battery (WAB), Neuropsychiatric Inventory‐plus (NPI‐plus), Stereotypy Rating Inventory (SRI), and frontal behavioural symptom scores obtained from items of NPI‐plus and SRI, were conducted to assess inter‐ and intra‐rater reliability, validity, and responsiveness. We performed receiver operating characteristic (ROC) curve analysis to evaluate the discriminating power of the Behaviour/Comportment/Personality (BEHAV) and Language (LANG) domains of the CDR® plus NACC FTLD and the MEMORY domain of the CDR® in patients AD dementia and FTD.ResultsThe CDR® plus NACC FTLD showed good inter‐ and intra‐rater reliabilities. In patients with FTD, the BEHAV domain of the CDR® plus NACC FTLD was significantly correlated with all clinical measures except for the SRI total score, while the LANG domain of the CDR® plus NACC FTLD was significantly correlated with the MMSE and the WAB‐Aphasia quotient. In addition, the CDR® plus NACC FTLD sum of boxes significantly changed after 6 months and after 1 year. ROC curve analysis showed that the BEHAV and LANG domains of the CDR® plus NACC FTLD distinguished between patients with AD dementia and FTD better than the MEMORY domain of the CDR®.ConclusionsThis study validated the Japanese version of the CDR® plus NACC FTLD with good reliability, validity, and responsiveness.
Nationalistic bias in collusion prosecution: the case for international antitrust agreements
Authors: Garcia Filomena , Paz y Miño Jose Manuel , Torrens Gustavo 
Published: December 2023

AbstractWe study the incentives of competition authorities to prosecute collusive practices of domestic and foreign firms in a multimarket contact model between two firms operating in two countries. In equilibrium, the country of origin of the firms might prefer to delay prosecution to protect profits in foreign markets. This strategic delay is valuable because prosecution in the country of origin of the firms activates an information spillover that triggers prosecution in the foreign country. Prosecution delays, however, are suboptimal under global welfare. With multiple industries, both countries can be better off under integration or signing an international antitrust agreement.