bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Networks as a Factor of the Formation of Cultural Values and Norms
Authors: Gavrylyuk Oleh 
Published: October 2023

The purpose of the article is to reveal the essence of the mutual influence of social and cultural values and norms. The research methodology is based on the application of general scientific methods of system analysis, as well as the theory of social networks; to clarify the essence of the mutual influence of social and cultural values and norms, the method of logical reconstruction was used. The scientific novelty of the results obtained consists in a comprehensive analysis of the specifics of the manifestation of the mutual influence of social and cultural values and norms. Conclusions. The entire modern global socio-cultural space is built on the network principle, and society is dominated by various network structures, the spread of which is due to the development of digital technologies, the emergence of which, in turn, is due to the needs of society and people to overcome spaces and various restrictions in communication and obtaining information. At the same time, each network structure has its own cultural dimension. Social networks are characterised by accessibility, globality, the presence of feedback, which indicates their constructive potential in the modern socio-cultural space. It is emphasised that the influence of social networks on culture is obvious – social networks have changed not only how people interact with each other, build relationships, consume information and make decisions, but also determined the mutual influence of social networks and culture. It has been concluded that in modern society social networks are a mechanism for preserving and simultaneously transmitting cultural values and norms, as well as for consolidating, self-organising and cultural identification of social groups. Social networks are changing cultural values and norms, manifested in intercultural and international communication, the way people interact with each other; perceptions of oneself and one's relationships with others. At the same time, cultural values influence social networks, dictating to them the need to comply with certain social norms.
Keywords: social networks, network structures, digital technologies, cultural values, cultural norms.
Correlation Of Positive IgM or IgG RDT (Rapid Diagnostic Test) Results with CRP (C-Reactive Protein) Levels in Dengue Hemorrhagic Fever Patients
Authors: Salsabila Yaumi Tasu’a , Ariami Pancawati , Wiadnya Ida Bagus Rai , Manu Thomas Tandi 
Published: October 2023

Background: Laboratory diagnosis of Dengue Hemorrhagic Fever includes the IgM & IgG RDT (Rapid Diagnostic Test) examination which differentiates primary and secondary dengue infection. The presence of inflammation in the body caused by the dengue virus needs to be examined for C-Reactive Protein. Methods: This research is an analytical observational study with a cross sectional approach. Thesample used is a plasma sample of a patient diagnosed with DHF with a positive IgM or IgG RDT result. Results: Positive IgM RDT results were 6 people (17%) and positive IgG were 30 people (83%). The results of a qualitative CRP study were 24 people (67%) with positive CRP levels. Semi-quantitative CRP average level for positive IgG was29.33. The results of the Spearman's Rank statistical test obtained a value of p = 0.003 <0.05 which showed a significant result. Conclusion:Clinically it shows that the more positive IgM or IgG RDT results obtained, the higher the CRP level which indicates the severity/inflammation that is formed in the body.
Tuna, Tempe, and Moora-Based Nuggets Prevent Stunting: Organoleptic Tests, Water Content, and ASH Content
Authors: Darni Joyeti , Wahyuningsih Retno 
Published: October 2023

Background: Stunting is associated with suboptimal brain development, which has long-term implications for cognitive abilities, school performance, and future employment. There is a relationship between fish consumption and the incidence of stunting in children. Fish nuggets are one alternative to increase fish consumption. Fish nuggets combination of tempeh and moringa leaves can be taught to the community to increase children's protein intake. The nugget formulation used consists of 60% tuna, 20% tempeh, and 20% moringa leaves. The purpose of this study was to determine organoleptic tests, water content and ash content of nuggets made from a mixture of tuna, tempeh and moringa leaves.Research Methods: This study is an experimental research. The research was conducted in the laboratory of the Faculty of Food Technology and Agroindustry, University of Mataram to analyze the water content and ash content of nuggets. Research was also conducted at the taste test laboratory of the Health Polytechnic of the Ministry of Mataram.Research Result: Overall reception 60% Panelists really liked the nuggets made from Tuna, Tempeh and Moringa Leaves. Water content and ash content meet the quality requirements of SNI fish nuggets.Conclusion: The results of the organoleptic test with the parameters of color, taste, aroma, texture, and overall acceptability concluded that the overall acceptability was 60%. Panelists liked Tuna, Tempeh, and Moringa fish-based nuggets. The water and ash content meet the SNI quality requirements for fish nuggets.
Reflective Writing in Basic Nursing Concept Course: A Qualitative Study of Nursing Students
Authors: Tambunan Evelyn Hemme , Simbolon Idauli 
Published: October 2023

Nursing students need to be trained in reflective competence as early as possible since it is an essential attribute for developing autonomous, critical and advanced practitioners in the future. However, there remains less attention in the usage at the bachelor nursing programs, particularly in the first year level. This study aimed to explore freshman nursing students’ reflective writing experience in basic nursing concept courses. Descriptive qualitative study was used in this study. Focus group interviews using zoom meeting platform were conducted with ten participants recruited through purposive sampling using the inclusion criteria, such as freshman nursing students who successively take basic nursing concept courses in semester 1 and 2 in academic year of 2019-2020 and attended learning process using reflective writing. Data were analyzed using qualitative content analysis. The experience of freshmen nursing students of reflective writing can be summarized into three themes, including difficulty at the initial process, challenging in the progress, and satisfying at the end of the process. Although freshmen nursing students struggled to understand the purpose and work on reflective writing, by the end of the two semesters, it had become a fun and satisfying experience. It has benefited both the learning process and the students personal lives. Students will be challenged to become proficient in reflective writing and improve self regulated learning over the course of two semesters. Reflective writing utilization based on other guidelines could be adopted. Nursing student critical thinking evaluation in reflective writing successively is needed to be considered
HUBUNGAN PENGETAHUAN IBU DENGAN PEMBERIAN ASI EKSKLUSIF PADA BAYI USIA 0 - 6 BULAN
Authors: Fariningsih Erika , Ikramah Dara Nauratul , Laska Yulinda 
Published: October 2023

ASI eksklusif adalah memberikan ASI saja tanpa makanan tambahan lain sampai bayi berusia 6 bulan kecuali vitamin dan obat-obatan. ASI diproduksi karena pengaruh hormone prolactin dan oksitosin setelah kelahiran bayi. ASI pertama yang keluar disebut kolostrum dan mengandung banyak immunoglobin IgA yang baik untuk mempertahankan tubuh bayi melawan penyakit.Penelitian ini merupakan penelitian kuantitatif survei analitik dengan pendekatan cross sectional yang diambil menggunakan teknik jugdement sampling. Yang berjumlah 40 responden.Hasil dari peneliti yaitu Sebagian besar responden memiliki pengetahuan yang baik tentang ASI Eksklusif sebanyak 37 responden (92,5%). Dari hasil analisis data dengan uji Fisher’s Exact didapatkan nilai P-Value< 0,05 (0.004).Kesimpulan dari hasil penelitian ini yaitu ada hubungan pengetahuan ibu dengan pemberian air susu ibu eksklusif di wilayah kerja Puskesmas Tanjung Uncang karena tingkat pengetahuan ibu tentang ASI Eksklusif di wilayah kerja Puskesmas Tanjung Uncang mayoritas baik. RELATIONSHIP OF MOTHER'S KNOWLEDGE WITH EXCLUSIVE BREASTMILK IN BABIES AGED 0 - 6 MONTHS AbstractExclusive breastfeeding is defined as feeding breast milk without any additional nutritions, except vitamins and medications, until a baby is 6 months old. Breast milk is produced due to the effect of prolactin hormone and oxytocin after birth. The first form of breast milk is called colostrum and contains much immunoglobin IgA which is beneficial to sustain a baby's body against illness.This research is a quantitative analytical survey with cross sectional approach which uses judgment sampling method with 40 respondents in total.Results found by thus researcher is that most respondents have good knowledge on exclusive breastfeeding, consisting of 37 respondents (92,5%). From data analysis results with Fisher’s Exact test, the p value is under 0.05 (i.e. 0.004).It is concluded that there are correlations between the knowledge of the mother with exclusive breastfeeding in Puskesmas Tanjung Uncang because the level of knowledge of most mother towards exclusive breastfeeding in Puskesmas Tanjung Uncang is good.
KEPASTIAN HUKUM PENDAFTARAN TANAH SECARA SISTEMATIS LENGKAP (PTSL) DI KABUPATEN MADIUN
Authors: Rajasa Aqsa , Suhartono Slamet 
Published: October 2023

Abstract— Penelitian ini bertujuan untuk mengetahui dan menjelaskan implementasi pendaftaran tanah melalui Program Pendaftaran Tanah Sistematis Lengkap (PTSL) di Kabupaten Madiun dan menganalisis perlindungan hukum terhadap sertifikat tanah Program Pendaftaran Tanah Sistematis Lengkap (PTSL) di Kabupaten Madiun. Metode penelitian ini menggunakan jenis penelitian hukum normatif merupakan suatu kegiatan penelitian hukum yang dilakukan untuk memecahkan isu hukum yang tengah dihadapi dengan menemukan suatu kebenaran koherensi. Dengan menggunakan pendekatan undang-undang dan pendekatan konsep, Dimana sumber bahan hukum yaitu bahan hukum primer dan bahan hukum sekunder serta dilakukan analisis bahan hukum secara dedukdif dari sesuatuyang umum menuju ke khusus dan bersifat preskriptif melalui metode penafsiran. Berdasarkan hasil penelitian pelaksaanaan PTSL di Kabupaten Madiun berpengaruh positif terhadap terciptanya tertib pertanahan, yaitu tertib hukum dan tertib administrasi pertanahan, ditunjukkan dengan banyaknya bidang tanah yang telah mampu disertipikatkan dalam proses PTSL. Hal ini menunjukkan adanya efektivitas hukum dan kesadaraan hukum masyarakat meskipun dalam pelaksanaan PTSL masih ditemukan beberapa kendala baik internal maupun eksternal dan perlindungan hukum bagi pemegang sertifikat PTSL yang diterbitkan BPN akan menjadi bukti dan dapat menjadi alat pembuktian di pengadilan. UUPA dan Peraturan Pemerintah Nomor 24 Tahun 1997, memberikan perlindungan hukum sepanjang tidak ada pihak lain yang dapat membuktikan sebaliknya. Untuk dapat menjadi pembuktian yang mutlak, berdasar Pasal 32 ayat (2) Peraturan Pemerintah Nomor 24 Tahun 1997, ditentukan bahwa apabila dalam jangka waktu 5 (lima) setelah penerbitan Sertipikat tidak ada pihak lain yang mengajukan keberatan dan gugatan, maka pihak yang merasa sebagai pemilik atas tanah itu tidak dapat menuntut hak atas tanah tersebut.
Investigating the biochemical association of gestational diabetes mellitus with dyslipidemia and hemoglobin
Authors: Akash Muhammad Sajid Hamid , Noureen Sibgha , Rehman Kanwal , Nadeem Ahmed , Khan Mohsin Abbas 
Published: October 2023

AimsTo investigate the biochemical correlation of hemoglobin (Hb), dyslipidemia, and HbA1c with gestational diabetes mellitus (GDM).BackgroundGDM is a condition that develops during pregnancy and is characterized by high blood sugar levels. Biochemical parameters such as hemoglobin (Hb), dyslipidemia, and HbA1c have been implicated in the development of GDM. Understanding the correlation between these biochemical parameters and GDM can provide insights into the underlying mechanisms and potential diagnostic markers for the condition.ObjectiveThe objective of this study was to evaluate the correlation of various biochemical parameters, including Hb, dyslipidemia, and HbA1c, in pregnant women with and without GDM.MethodA cross-sectional study design was used. Pregnant females attending a tertiary care hospital in Faisalabad between September 1st, 2021, and June 25th, 2022, were included in the study. The participants were divided into two groups: those with GDM (GDM group) and those without GDM (non-GDM group). Blood glucose, Hb, and lipid levels were compared between the two groups using statistical tests, including chi-square, independent sample t-test, and Pearson’s correlation.ResultOut of the 500 participants, 261 were in the 2nd trimester and 239 in the 3rd trimester. Maternal age showed a significant difference between the GDM and non-GDM groups. The levels of Hb, TC, HDL, LDL, and HbA1c significantly differed (p &lt; 0.05) between the two groups. TC (r = 0.397), TG (r = 0.290), and LDL (r = 0.509) showed a statistically significant and moderately positive correlation with GDM. HDL (r = −0.394) and Hb (r = −0.294) showed a moderate negative correlation with GDM.ConclusionIncreased levels of HbA1c, TC, and LDL, along with decreased levels of HDL and Hb, were identified as contributing factors to GDM. The levels of TC, TG, and LDL were positively correlated with GDM, while HDL and Hb were negatively correlated. The findings of this study suggest that monitoring and managing hemoglobin, dyslipidemia, and HbA1c levels during pregnancy may be important in identifying and potentially preventing or managing GDM. Further research is needed to explore the underlying mechanisms and potential interventions targeting these biochemical parameters in relation to GDM.
Brain language networks and cognitive outcomes in children with frontotemporal lobe epilepsy
Authors: Hüsser Alejandra M. , Vannasing Phetsamone , Tremblay Julie , Osterman Bradley , Lortie Anne , Diadori Paola , Major Philippe , Rossignol Elsa , Roger Kassandra , Fourdain Solène , Provost Sarah , Maalouf Yara , Nguyen Dang Khoa , Gallagher Anne 
Published: October 2023

IntroductionPediatric frontal and temporal lobe epilepsies (FLE, TLE) have been associated with language impairments and structural and functional brain alterations. However, there is no clear consensus regarding the specific patterns of cerebral reorganization of language networks in these patients. The current study aims at characterizing the cerebral language networks in children with FLE or TLE, and the association between brain network characteristics and cognitive abilities.MethodsTwenty (20) children with FLE or TLE aged between 6 and 18 years and 29 age- and sex-matched healthy controls underwent a neuropsychological evaluation and a simultaneous functional near-infrared spectroscopy and electroencephalography (fNIRS-EEG) recording at rest and during a receptive language task. EEG was used to identify potential subclinical seizures in patients. We removed these time intervals from the fNIRS signal to investigate language brain networks and not epileptogenic networks. Functional connectivity matrices on fNIRS oxy-hemoglobin concentration changes were computed using cross-correlations between all channels.Results and discussionGroup comparisons of residual matrices (=individual task-based matrix minus individual resting-state matrix) revealed significantly reduced connectivity within the left and between hemispheres, increased connectivity within the right hemisphere and higher right hemispheric local efficiency for the epilepsy group compared to the control group. The epilepsy group had significantly lower cognitive performance in all domains compared to their healthy peers. Epilepsy patients’ local network efficiency in the left hemisphere was negatively associated with the estimated IQ (p = 0.014), suggesting that brain reorganization in response to FLE and TLE does not allow for an optimal cognitive development.
Outcome after proton beam therapy versus photon-based radiation therapy in childhood-onset craniopharyngioma patients—results of KRANIOPHARYNGEOM 2007
Authors: Friedrich Carsten , Boekhoff Svenja , Bischoff Martin , Beckhaus Julia , Sowithayasakul Panjarat , Calaminus Gabriele , Eveslage Maria , Valentini Chiara , Bison Brigitte , Harrabi Semi B. , Krause Mechthild , Timmermann Beate , Müller Hermann L. 
Published: October 2023

BackgroundProton beam therapy (PBT) is being increas16ingly used to treat residual craniopharyngioma (CP) after hypothalamus-sparing surgery. Compared to photon-based radiation therapy (XRT) with PBT, less irradiation in the penumbra reduces the scattered dose to critical organs neighboring but outside the area of treatment, minimizing the risk of sequelae.Patients and methodsBetween 2007 and 2019, 99 of 290 (34%) childhood-onset CP patients recruited in KRANIOPHARYNGEOM 2007 received external radiation therapy (RT) (65% PBT, 35% XRT). Outcome was analyzed in terms of survival, endocrinological and anthropometric parameters (BMI and height SDS), quality of life (QoL using PEDQOL), and functional capacity (FMH) with special regard to irradiation technique.ResultsPBT became predominant (used in 43% and 72% of all irradiated patients registered within the first and second halves of the recruitment period, between 2008 and 2013 and 2013 and 2018, respectively). Five-year event-free survival rates after PBT or XRT were comparable (92% ± 4% vs. 91% ± 4%, p = 0.42) and higher than for the whole cohort since diagnosis, including non-RT patients (37% ± 4%). Radiation doses to the hypothalamus and pituitary did not differ between PBT and XRT. Endocrine deficits due to disturbances of the hypothalamic-pituitary axis (HPA) were already common before irradiation. During the first 5 years after CP diagnosis/RT, no differences between PBT, XRT, and non-RT CP patients concerning functional capacity and anthropometric parameters have been obtained. Only for the PEDQOL domain “physical function”, parental-assessed QoL was lower 12 months after PBT versus XRT or non-RT patients.ConclusionQoL, functional capacity, degree of obesity, and endocrinopathy varied over time from diagnosis, but by 5 years, there was no significant difference between PBT and XRT upfront or delayed, nor was there any compromise in historic survival rates, which remained high &gt;90%. RT of any type is extremely effective at stabilizing disease after hypothalamic-sparing surgery. The purported specific benefits of PBT-reducing sequelae are not proven in this study where the organ of critical interest is itself diseased, increasing an urgent need to better address and treat the tumor-induced endocrine harm from diagnosis in dedicated pituitary services. Other hypothesized benefits of PBT versus XRT on vascular events and secondary cancers await longer comparison.Clinical trial registration numberhttps://clinicaltrials.gov/study/, identifier NCT01272622.
Development and validation of a novel anoikis-related gene signature in clear cell renal cell carcinoma
Authors: Wu Qihang , Sun Yuxiang , Qin Xiangcheng , Li Maomao , Huang Shuaishuai , Wang Xue , Weng Guobin 
Published: October 2023

BackgroundDespite numerous treatments available, clear cell renal cell carcinoma (ccRCC) remains a deadly and invasive cancer. Anoikis-related genes (ARGs) are essential regulators of tumor metastasis and development. However, the potential roles of ARGs in ccRCC remain unclear.MethodsBased on the TCGA-KIRC cohort and GeneCards database, we identified differentially expressed ARGs in ccRCC. Then a 4 ARGs risk model was created by Cox regression and LASSO. The Kaplan-Meier and receiver operating characteristic (ROC) curves were utilized to verify the predictive efficacy of the prognostic signature. Subsequently, the possible molecular mechanism of ARGs was investigated by functional enrichment analysis. To assess the immune infiltration, immune checkpoint genes, and immune function in various risk groups, single sample gene set enrichment (ssGSEA) algorithm was employed. Furthermore, the low-risk and high-risk groups were compared in terms of tumor mutation burden (TMB). Ultimately, we analyzed the protein expression of these four ARGs utilizing the western blot test.ResultsFour genes were utilized to create a risk signature that may predict prognosis, enabling the classification of KIRC patients into groups with low or high risk. The reliability of the signature was examined utilizing survival analysis and ROC analysis. According to the multivariate Cox regression result, the risk score was a reliable independent prognostic predictor for KIRC patients. The novel risk model could differentiate between KIRC patients with various clinical outcomes and represent KIRC’s specific immune status. An analysis of the correlation of TMB and risk score indicated a positive correlation between them, with high TMB being potentially linked to worse outcomes.ConclusionBased on our findings, the prognostic signature of ARGs may be employed as an independent prognostic factor for ccRCC patients. It may introduce alternative perspectives on prognosis evaluation and serve as a prominent reference for personalized and precise therapy in KIRC.
Invasive fungal infections in pediatric patients with central nervous system tumors: novel insights for prophylactic treatments?
Authors: Dassi Natália , Cappellano Andrea Maria , Silva Adriana Maria Paixão de Sousa da , da Silva Nasjla Saba , Carlesse Fabianne Altruda de Moraes Costa 
Published: October 2023

Background and aimsInvasive fungal disease (IFD) poses significant morbidity and mortality risks, especially in pediatric patients with neoplastic diseases. However, there is a notable lack of data concerning patients with central nervous system (CNS) tumors. Considering vulnerability factors to infections such as neutropenia, corticosteroids, chemotherapy, surgical interventions, and others, this study aims to evaluate the incidence of IFD in pediatric patients with CNS tumors and determine appropriate indications for prophylactic measures. This is a single-center, retrospective study conducted between 2011 and 2022 at the Pediatric Institute of Oncology (IOP-GRAACC-UNIFESP).ResultsA total of 38 cases of IFD were diagnosed in 818 children with CNS malignancies (4,6%). The mean age was 3.5 years (0.4-28y), with 22 (57.9%) male patients. Embryonal tumors (18/38, 47.3%) were the most prevalent CNS tumors, followed by low-grade gliomas (13/38, 34.2%). All episodes met the EORTC IFD criteria, and 36/38 (94.7%) were proven. Invasive yeast infections (33/36, 91.6%), predominantly Candida (30/33, 90.9%), were the most common diagnosis. In total, 25 patients (25/38, 65.8%) were receiving chemotherapy, with 13 of them having embryonal tumors. A total of 11 infants were in the Head Start scheme, resulting in a high prevalence of IFD in these group of patients (11/58, 18.9%). In total, 13 (13/38, 34.2%) patients underwent neurosurgery, mostly ventricular-peritoneal shunts revisions (10/13, 76.9%). Nine (9/38, 23.7%) were with prolonged use of corticosteroids, eight of them associated with neurosurgery.ConclusionRoutine systemic antifungal prophylaxis based solely on diagnosis is not recommended for low-risk cases. Evaluating patient- and treatment-specific risk factors is crucial in infants undergoing high-dose chemotherapy with expected neutropenia and in patients requiring prolonged corticosteroid therapy alongside neurosurgical procedures.