bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-eclampsia related TLR2/4 signaling activates NOX2/4 to induce oxidative stress and ferroptosis in trophoblasts
Authors: Zhang Yan , Zhang Jinman , Zhu Baosheng , Ren li , Wu Jie , Dong Xudong 
Published: December 2023

Abstract
Pre-eclampsia (PE) is a pregnancy-related complication which is closely related to the malfunction of trophoblasts. Oxidative stress and ferroptosis have been recognized as detrimental factors linked with trophoblast dysfunction. Nevertheless, the signaling pathways dictating the oxidative stress and ferroptosis in placental tissues of PE patients are unclear. In this study, we investigated the roles of Toll-like receptor (TLR) signaling in PE-induced ferroptosis in the placenta tissues and explored the therapeutic potential of targeting TLR signaling in the animal model of PE. The expression levels of TLR2/4 and MAPK signaling activation were compared in the placental tissues between healthy controls and PE patients. The role of TLR2/4 and MAPK signaling in ischemia-induced ferroptosis was investigated in the trophoblasts with hypoxia/re-oxygenation (H/R) induction. TLR and NADPH Oxidase (NOX) inhibitors were applied in the rat model of PE to evaluate the therapeutic potential. We found the upregulation of TLR2/4 and the over-activation of MAPK signaling in the placental tissues of PE patients and in the H/R induced trophoblasts. Inhibiting TLR2/4 expression reduced MAPK signaling and improved trophoblast functions after H/R induction. TLR2/4 signaling dependent NOX2 and NOX4 upregulation contributed to the oxidative stress and ferroptosis in trophoblasts upon H/R induction. In the rat model of PE, inhibiting TLR2/4 and NOX activity prevented ferroptotic events in the placental tissues. Collectively, our findings suggest that TLR2/4-dependent oxidative stress and ferroptosis may undermine the function of trophoblasts in the PE placenta, and targeting TLR signaling-mediated ferroptosis could serve as an intervention strategy of PE.
Exploring the Psychological Consequences and Coping Strategies of Architecture Students Following the Massive Earthquakes in Turkey
Authors: Ozenen Gurkan 
Published: December 2023

Abstract
This study aimed to investigate the psychological impact of earthquakes on architecture students in Turkey. The study involved 96 participants from two different universities who completed an online survey. The survey assessed participants’ experiences of earthquake-related distress, their coping strategies, and their perceived social support. Results showed that a significant proportion of participants reported experiencing high levels of distress following the earthquake, with female participants reporting higher levels of distress than males. Coping strategies included seeking emotional support from friends and family, engaging in religious practices, and engaging in physical activity. Perceived social support was found to be a significant predictor of earthquake-related distress, with higher levels of social support associated with lower levels of distress. These findings highlight the importance of providing support to architecture students who are affected by earthquakes, and suggest that interventions that focus on enhancing social support may be effective in reducing earthquake-related distress. This is the first study that attempted to assess the psychological wellbeing of university students in the aftermath of the catastrophic Kahramanmaras, Turkey earthquake in 2023, which caused thousands of fatalities and serious injuries, including limb amputations. Essentially, this study adds to the existing literature on the psychological impact of earthquakes, and has important implications for the design of interventions aimed at supporting individuals who are affected by natural disasters.
Bovine Tuberculosis in Cattle Slaughtered at Abattoir in Ethiopia and Workforce Awareness of Zoonotic Risk
Authors: Mohammed Fahmi , Girma Musse , Worku Getnet , Medhin Girmay , Waddell Simon J , Gumi Balako 
Published: December 2023

Abstract

Background
Bovine tuberculosis (bTB) is endemic and of zoonotic importance in Ethiopia. Despite this, there is limited recent information on the prevalence of bTB in cattle slaughtered at abattoirs. This study reports the prevalence of bTB in cattle slaughtered at the Addis Ababa municipality abattoir and details an assessment of practice and the awareness of occupational workers to zoonoses.
Methods
A cross-sectional study was conducted at the Addis Ababa municipality abattoir from May 2021 to July 2022. A total of 502 cattle slaughtered at the municipality abattoir (260 in the day shift and 242 in the night shift) were included in the study. Data collection and laboratory investigations included postmortem examination, culture and bacteriological examination, molecular characterization of positive isolates using region of difference (RD4) deletion typing and spoligotyping. Knowledge of zoonotic infection risk and practices were investigated through a questionnaire administered to 58 abattoir workers and 58 butchers.
Results
Based on postmortem examination, bTB suspected lesion was identified in 4.58% of cattle and it was significantly associated with, age, breed and body condition of the animals. Detection of tuberculosis lesions was higher during the night shift of the slaughter program. The gross lesions were predominately found in the lung and associated lymph nodes (60.87%). Of the 23 bTB suspected tuberculous lesions, 11 (47.83%) tissue samples were culture positive, and four isolates were RD4 positive, identifying M. bovis. Spoligotyping patterns were also effectively detected in four isolates. The observed spoligotype patterns were two SB1477 strains, and SB1176 and SB0133 strains. In the questionnaire survey, 79.31% of abattoir workers were aware of bTB, however, 93.10% of butchers did not know of bTB and understood less about preventing cross-infection.
Conclusion
Bovine tuberculosis is still evident in cattle reaching the abattoir in Addis Ababa. Higher detection of tuberculous lesions during the night suggests a need for improved meat inspections during the night shift to reduce the public health risk of bTB zoonosis.
Impact of Dark Triad Personality Traits on COVID-19 Vaccination Uptake and Prevention Efforts: Insights from the European Covid Survey (ECOS)
Authors: Bock Sophia , Neumann-Böhme Sebastian , Steinorth Petra 
Published: December 2023

Abstract
Background: Even though the COVID-19 vaccination roll-out in general can be considered as one of the most successful public health campaigns in the history of medicine, general vaccination hesitancy has remained an issue of concern throughout the world. We add to a deeper understanding of vaccination hesitancy by identifying what drives primary vaccination and booster uptake, as well as adherence to simple preventive measures such as physical distancing by investigating the role of Dark Triad personality traits, i.e. Machiavellianism, narcissism, and psychopathy.
Methods: We investigate data from Germany and the United Kingdom from the European Covid Survey which was collected from 23 December 2021 to 10 January 2022. Logit regressions and random effects regressions were performed to study the effect of dark personality traits on COVID-19-related prevention.
Results: We show that Dark Triad personality traits have a substantial impact on prevention efforts, primary vaccinations and booster uptake against COVID-19. Specifically, individuals scoring high in psychopathy have significantly less likely received primary immunization. The difference amounts to 10.5%-points. High narcissistic personality traits imply a substantially higher likelihood (15.3%-points) to refuse booster shots after having received the primary vaccinations. Therefore, the Dark Triad personality traits may constitute a special case in the demand for vaccines. In addition, individuals with higher psychopathic tendencies engage significantly less in other simple preventive behavior, while higher scores in narcissism lead to higher reported adherence to simple preventive measures.
Conclusions: Our findings highlight the crucial role that personality plays in pandemic related prevention. Policymakers, health professionals, and those in charge of health messaging may take these factors into account when devising communication strategies to improve the vaccination uptake and adherence to preventive behaviors. Future pandemics and public health crises would benefit from targeted, nuanced approaches to public health messaging to promote greater public adherence and public health.
Small Target Disease Detection based on YOLOv5 Framework for Intelligent Bridges
Authors: Zhang Tingping , Xiong Yuanjun , Jiang Shixin , Dan Pingxi , Gui Guan 
Published: December 2023

Abstract
This paper proposes a small target disease detection method using YOLOv5 framework for detecting small apparent diseases on intelligent bridges, aiming to address the problem of missed and false detection. To enhance the detection of small apparent diseases, a layer for detecting small objects is added to the YOLOv5 model. Additionally, an ECA attention mechanism module is embedded in the feature enhancement network to improve the extraction of disease features. To validate the effectiveness of the proposed algorithm, a dataset of 996 bridges with apparent diseases such as corrosion, rebar, speckle, hole and spall was established and trained after manual annotation and data augmentation. The experiment showed that the proposed algorithm achieves a mAP of 87.91%. Compared to the original YOLOv5 model, the proposed algorithm improved the mAP on the bridge apparent disease dataset by 1.97%. This algorithm accurately detects small apparent diseases on bridges and effectively reduces missed detection.
Optimal trajectory planning combiningmodel-based and data-driven hybrid approaches
Authors: Ghnatios Chady , Lorenzo Daniele di , Champaney Victor , Ammar Amine , Elias Cueto , Chinesta Francisco 
Published: December 2023

Abstract

Trajectory planning aims at computing an optimal trajectory through theminimization of a cost function. This paper considers four dierent scenarios: (i)the rst concerns a given trajectory on which a cost function is minimized by aacting on the velocity along it; (ii) the second considers trajectories expressedparametrically, from which an optimal path and the velocity along it arecomputed; (iii), the case in which only the departure and arrival points of thetrajectory are known, and the optimal path (in the sense of minimizing a givencost function) must be determined; and nally, (iv) the case involving uncertaintyin the environment in which the trajectory operates. When the considered costfunctions are expressed analytically, the application of Euler-Lagrange equationsconstitutes an appealing option. However, in many applications, complex costfunctions are learned by using black-box machine learning techniques, for instancedeep neural networks. In such cases, a neural approach of the trajectory planningbecomes an appealing alternative. Dierent numerical experiments will serve toillustrate the potential of the proposed methodologies on some selected use cases.
Harnessing the Power of Bacillus subtilis MR42: Direct Production of Defined Xylo-Oligosaccharides (XOS) from Corn Stalks with Enhanced Prebiotic Properties
Authors: Wei Lusha , Sun Shuo , Chen Yuan , An Xin , Wu Hanning , Wu Yifei 
Published: December 2023

Abstract
The production of value-added bioproducts from renewable carbon sources has gained increasing attention in recent years. Bacillus subtilis MR42 was used to produce specific xylooligosaccharides (XOS) from corn stalks. This strain, through a genetic modification targeting the xynC gene, can convert arabinoxylan into specific XOS without generating xylose as a byproduct. Under optimal conditions, a high yield of XOS (703.4 mg/g xylan) was obtained. The purified XOS were further characterized using various techniques including TLC, HPLC, ESI-MS and 1HNMR spectroscopy. The analysis revealed that the XOS primarily consisted of xylotriose (289 ± 0.03 mg/g), xylotetraose (237 ± 0.05 mg/g) and xylopentaose (267 ± 0.03 mg/g), accounting for approximately 80% of the total XOS. The prebiotic effect of XOS was evaluated by examining its impact on the growth of Lactobacillus, the production of short-chain fatty acids, and its antioxidant activity. B. subtilis MR42 showed a promising ability to produce short DP of XOS without xylose.
Analysis of Structural Strength and Fatigue Life of Hazardous Chemical Tank Truck
Authors: Xiaoyan Han , Lixin Ma , Yongbing Gu , Yichao Cao , Wenjie Ding 
Published: December 2023

Abstract
In this paper, the safety and durability of the structure of the hazardous chemical tanker is evaluated by analyzing the strength and fatigue life of the tank body. By using finite element analysis software, the stress and deformation of key components such as front vessel head, wave plates and rear vesse head of tank truck are analyzed in detail, and the fatigue life under impact load is calculated. The greatest stress is located at the connection between the vessel head and the cylinder, and the front vessel head is greater. The maximum fatigue damage occurred on the structure of the wave plate.
Chinese Women Recover Slower Than Western Women After Cancer-Related Breast Reconstruction: A Prospective Descriptive Study Using Patient-Reported Outcome Measurement for Breast Surgery
Authors: CHANG Ting-Yu , WANG Tongyao , Lin Chia-Chin 
Published: December 2023

Abstract

Purpose: The patient-reported outcome measurement for breast surgery (BREAST-Q) has been widely used to assess the physical, psychosocial, and breast satisfaction of women undergoing breast reconstruction surgery. However, so far, there is no traditional Chinese version available. The study aims (1) to perform the psychometric evaluation of the traditional Chinese version of the BREAST-Q core and reconstruction modules and (2) to describe Chinese women’s experiences using the BREAST-Q.
Methods: We first translated and pilot tested the BREAST-Q, then recruited patients (N = 155) undergoing silicone breast reconstruction surgery.
Results: The BREAST-Q had Cronbach's alpha values of 0.87 and 0.92 for the pre- and post-surgical reconstruction versions, with a content validity index of 0.96 and 0.98, respectively. Having a normal BMI was only related to pre-operative psychosocial wellbeing and breast satisfaction. Compared to the BREAST-Q clinical references of the US population, we found that participants experienced consistently lower physical, psychosocial, and sexual quality of life before and after their breast reconstruction surgeries, and at the six-month follow-up, there were significant deteriorations in the physical, psychosocial, and breast satisfaction domains and no improvement in sexual wellbeing.
Conclusion: The findings indicate that Chinese women are likely to be more vulnerable to the physical and psychosocial impact of changes in breast, including surgical breast reconstruction, than women in the US and thus experience a slower recovery process. Pre- and post-operative support should be designed to fit their unique survivorship trajectory.
Joint impact of advection and diffusion on the predator-prey coexistence in an open flow
Authors: Xin Shixia , Nie Hua , Shu Hongying 
Published: December 2023

Abstract
In this paper, we examine a predator-prey model with general reaction functions in open advective environments, where the predator and prey may employ distinct movement strategies. Using the coefficients of diffusion and advection as varying parameters, we conduct a quantitative analysis on the critical advection rates, which distinguish the different dynamics of this predator-prey system, to explore the joint impact of advection and diffusion on the invasion and coexistence of predators and prey in an open flow. It turns out that the dynamics may switch many times between a successful or failed invasion, coexistence or generalist predator take-over as the advection and diffusion rates of predators and prey vary, which suggests that both diffusion and advection play a crucial role in shaping the dynamics of the predator-prey system.
Mathematics Subject Classification. 35B35, 35K57, 92D25.
Effects of Dietary Restriction and One-Carbon Metabolite Supplementation During the First 63 Days of Gestation on the Maternal Gut, Vaginal, and Blood Microbiota in Cattle
Authors: Luecke Sarah M. , Aryee Godson , Holman Devin B. , Schmidt Kaycie N. , King Layla E. , Crouse Matthew S. , Ward Alison K. , Dahlen Carl R. , Caton Joel S. , Amat Samat 
Published: December 2023

Abstract

Background: Maternal diet quality and quantity have significant impacts on both maternal and fetal health and development. The composition and function of the maternal gut microbiome is also significantly influenced by diet; however, little is known about the impact of gestational nutrient restriction on the bovine maternal microbiome during early gestation, which is a critical stage for maternal microbiome-mediated fetal programming to take place. The objective of the present study was to evaluate the impacts of diet restriction and one-carbon metabolite (OCM) supplementation during early gestation on maternal ruminal, vaginal, and blood microbiota in cattle. Thirty-two beef heifers (approx. 14 months old) were used in a 2 × 2 factorial experiment with main factors of target gain (control [CON]; targeted 0.45 kg/d gain vs. restricted [RES]; targeted -0.23 kg/d gain), and OCM supplementation (+OCM vs. -OCM; n = 8/treatment). Heifers were individually fed, starting treatment at breeding (d 0) and concluding at d 63 of gestation. Ruminal fluid and vaginal swabs were collected on d -2, d 35, and d 63 (at necropsy) and whole blood was collected on d 63 (necropsy). Bacterial microbiota was assessed using 16S rRNA gene (V3 - V4) sequencing.
Results: Overall ruminal microbiota structure was affected by gain, OCM, time, and their interactions. The RES heifers had greater microbial richness (observed ASVs) but neither Shannon nor Inverse Simpson diversity was significantly influenced by gain or OCM supplementation; however, on d 63, 34 bacterial genera showed differential abundance in the ruminal fluid, with 25 genera enriched in RES heifers as compared to CON heifers. In addition, the overall interaction network structure of the ruminal microbiota changed due to diet restriction. The vaginal microbiota community structure was influenced by gain and time. Overall microbial richness and diversity of the vaginal microbiota steadily increased as pregnancy progressed. The vaginal ecological network structure was distinctive between RES and CON heifers with genera-genera interactions being intensified in RES heifers. A relatively diverse bacterial community was detected in blood samples, and the composition of the blood microbiota differed from that of ruminal and vaginal microbiota.
Conclusion: Restricted dietary intake during early gestation induced significant alterations in the ruminal microbiota which also extended to the vaginal microbiota. The composition of these two microbial communities was largely unaffected by OCM supplementation. Blood associated microbiota was largely distinctive from the ruminal and vaginal microbiota.
Major Depressive Disorder Trait Genes Promote Triple-Negative Breast Cancer Progression and Predict Immunotherapy Responses
Authors: Zhuo Zhili , Lu Wenping , Zhang Dongni , Cui Yongjia , Wu Xiaoqing , Mei Heting , Chang Lei , Song Qingya 
Published: December 2023

Abstract
TNBC is the most malignant subtype of breast cancer and there are no accurate and effective therapeutic targets. Immunotherapy is a promising approach for the treatment of TNBC. Anxiety and depression are among the most common concomitant symptoms in BC.MDD affects the functioning of the immune system, and its immune-related genes not only influence the pathophysiology of MDD, but may also increase the risk of BC recurrence and metastasis. This study revealed significant differences in T-lymphocyte infiltration between the high-risk and low-risk groups of TNBC differentiated on the basis of the characteristic inflammatory genes of MDD, which can help to screen the population for immunotherapy benefit and provide new ideas for future immunotherapy of TNBC. We aimed to identify MDD-related genes involved in the pathogenesis of TNBC and to provide predictive immunotherapy biomarkers for TNBC.
Synthesis and Characterization of Novel β-CD-Xanthate and Its Application in the Treatment of Heavy Metal Containing Wastewater and Lignin Enriched Paper Industry Wastewater
Authors: Chaurasiya Arbind , Pande Poorn , Shankar Ravi , Dey Kajal Kumar , Tripathi Narendra Pratap , Kushwaha Nandita , Kumar Tripathi Shivam Saroj 
Published: December 2023

Abstract
Three grades of xanthates of β-cyclodextrin (β-CD) viz. β-CDX1 β-CDX2 and β-CDX3 have been synthesized by the rection of β-CD with CS2 in alkaline medium (NaOH), through xanthation process. The synthesized β-CDXs have been characterized by UV, FTIR, 1HNMR, DSC, ΔpHPZC and SEM analysis. Further, β-CDXs and raw β-CD has been used for the heavy metals removal (Cu2+ and Ni2+) and also lignin removal from lignin enriched paper industry wastewater (LEPIW). The maximum % removal of β-CD, β-CDX1, β-CDX2 and β-CDX3 have been found to be 73.6, 91.9, 93.4 & 95.8% for Cu2+ ion and 65.8, 88.6, 91.3 & 94.1% for Ni2+ ion at optimum adsorbent dosage 2.0 g/L, pH 6.5, initial concentration 1000 mg/L, temperature 45 oC for Cu2+ and 55 oC for Ni2+, and contact time: 80 min for Cu2+ and 100 min for Ni2+ ion respectively. While LEPIW treatment efficacy of 54, 77, 83 and 86% has been noticed (initial COD: 2.0 g/L, pH: 7, optimum temperature: 40°C at 80 min operating time) for β-CD, β-CDX1, β-CDX2 and β-CDX3 respectively. The calculated data fitted well with Langmuir isotherm model confirming the adsorption of Cu2+ & Ni2+ ions onto the β-CDXs adsorbent is monolayer. The rate of adsorption of heavy metals (Cu2+ and Ni2+) on the β-CDXs adsorbent has been controlled by kinetic model of Pseudo second order indicating the chemisorption. The optimal adsorption capacities of β-CD, β-CDX1, β-CDX2 and β-CDX3 has been found to be 357.14, 473.93, 510.20 & 534.75 mg/g for Cu2+ and 294.11, 384.61, 408.16 & 423.72 mg/g and for Ni2+ ions, respectively.