bluuebunny/crossref_metadata_2025_split huggingface dataset:
AI credibility and consumer-AI experiences: a conceptual framework
Authors: Khan Abdul Wahid , Mishra Abhishek 
Published: December 2023

PurposeThis study aims to conceptualize the relationship of perceived artificial intelligence (AI) credibility with consumer-AI experiences. With the widespread deployment of AI in marketing and services, consumer-AI experiences are common and an emerging research area in marketing. Various factors affecting consumer-AI experiences have been studied, but one crucial factor – perceived AI credibility is relatively underexplored which the authors aim to envision and conceptualize.Design/methodology/approachThis study employs a conceptual development approach to propose relationships among constructs, supported by 34 semi-structured consumer interviews.FindingsThis study defines AI credibility using source credibility theory (SCT). The conceptual framework of this study shows how perceived AI credibility positively affects four consumer-AI experiences: (1) data capture, (2) classification, (3) delegation, and (4) social interaction. Perceived justice is proposed to mediate this effect. Improved consumer-AI experiences can elicit favorable consumer outcomes toward AI-enabled offerings, such as the intention to share data, follow recommendations, delegate tasks, and interact more. Individual and contextual moderators limit the positive effect of perceived AI credibility on consumer-AI experiences.Research limitations/implicationsThis study contributes to the emerging research on AI credibility and consumer-AI experiences that may improve consumer-AI experiences. This study offers a comprehensive model with consequences, mechanism, and moderators to guide future research.Practical implicationsThe authors guide marketers with ways to improve the four consumer-AI experiences by enhancing consumers' perceived AI credibility.Originality/valueThis study uses SCT to define AI credibility and takes a justice theory perspective to develop the conceptual framework.
The limitations of open innovation: an examination of innovation orientation, open innovation and performance in North America
Authors: Wilson Grant Alexander , Case Tyler , Dobni C. Brooke , Liguori Eric 
Published: December 2023

PurposePrior innovation orientation research has mostly focused on performance consequences, with some recent work examining its relationship with innovative practices such as open innovation. Yet, despite this growing body of open innovation research, there are still gaps and limitations. Notably, most prior studies have been conducted in Europe, limiting their generalizability to the rest of the world, and are replicative, exploring performance and competitive outcomes. There is very limited work examining the potential limitations of open innovation. This study extends innovation orientation research and examines the limitations of open innovation in North America.Design/methodology/approachThis study explores the relationships between innovation orientation and performance, open innovation and performance and innovation orientation and open innovation among 386 North American companies.FindingsThis study is novel as it examines the relationships between innovation orientation and performance, open innovation and performance and innovation orientation and open innovation among North American companies. The research uncovers a linear relationship between innovation orientation and performance, a correlation between innovation orientation and open innovation and a counterintuitive curvilinear relationship between open innovation and performance. The curvilinear relationship, shaped as an inverted u-shape, suggests there are limitations to the strategy's effectiveness, actionable insight to companies, consultants and scholars alike. In the discussion section, findings are further unpacked with regard to their implications for the scholarly literature. The paper concludes with managerial considerations for creating an innovation orientation and the most effective level of open innovation for maximum competitive and performance implications.Originality/valueBeyond the innovation orientation and open innovation research contributions, this study offers managerial insight for executives seeking to enhance competitiveness and drive firm performance.
Does geopolitical risk impact the natural resources—Economic growth nexus?
Authors: Hashmi Shabir Mohsin , Wan Muchun , Syed Qasim Raza 
Published: December 2023

AbstractThe existing literature on resource economics extensively probes the validity of the natural resource curse hypothesis; nevertheless, the empirical evidence at the global scale is relatively sparse. Further, the literature ignores the combined impact of geopolitical risk (GPR) and natural resources (NRR) on economic growth (EG). Based on this, we examine whether the natural resource curse hypothesis holds at the global level. Moreover, we investigate the combined impact of NRR and GPR on EG. We adopt the novel Fourier‐augmented ARDL method to provide reliable outcomes. The results delineate that NRR upsurge EG, thereby invalidating the resource curse hypothesis. Contrarily, the combined impact of NRR and GPR on EG is negative, thus, validating the resource curse hypothesis. We recommend a series of policy suggestions based on the outcomes.
Pathway to terrorist behaviors: The role of childhood experiences, personality traits, and ideological motivations in a sample of Iraqi prisoners
Authors: Cleary Sean D. , Candilis Philip J. , Dhumad Saleh , Dyer Allen R. , Khalifa Najat 
Published: December 2023

AbstractRadicalization to terrorism is a multifaceted process with no single theory or approach to explain it. Although research has focused on understanding the process, there is still a dearth of studies that examine an empirically driven pathway to terrorism behavior. This study examines a cross‐sectional sample of incarcerated men convicted of terrorism in Iraq (N = 160). A questionnaire‐guided interview included adverse childhood experiences (ACEs), conduct disorder (CD), antisocial personality disorder (ASPD), religious and political ideology, views about causes of terrorism, and the severity of terrorist acts. Path analysis was employed to examine the relationships between these factors and to identify the model with the best fit. After adjusting for age, employment, and location, results indicated that ACEs positively impacted CD, ASPD, religious guidance, and terrorism attitudes. ASPD positively affected political commitment and terrorism attitudes, but inversely affected current religious commitment. Political commitment inversely influenced terrorism attitudes. Religious commitment positively influenced the prioritization of religion in life, which subsequently impacted terrorism attitudes and behavior severity. Additionally, attitudes toward terrorism directly affected the severity of terrorism behavior. All paths in the final model were statistically significant at p < 0.05. Although these findings may be limited in generalizability due to the unique sample, results support the complex and interdependent nature of childhood and adult experiences on the development of both terrorism attitudes and the severity of terrorism behavior.
Validation of image stream hashing: A forensic method for content verification
Authors: Wales Gregory S. 
Published: December 2023

AbstractHow do forensic examiners know if they have altered an image stream when converting a digital image from one codec or file container to another for analysis? Forensic standards and best practices recommend avoiding alteration or degradation of multimedia data during transcoding. An image stream hashing method was recently introduced to the forensic science community to answer the question above. This paper offers an initial validation study of image stream hashing method that may answer the question above. The first half of the study's experiments tested the image stream hashing method to measure fitness for use in forensic science while identifying errors and limitations. The study's second phase analyzed the systematic errors detected in initial tests to discover error causation. Causation analysis identified four method limitations subsequently used to develop proposed standard controls of method operations. The final study phase repeated the initial experiments used in the first phase while implementing the proposed standard controls of method operations. Initial test results indicated the method had significant error rates, limiting the effectiveness of the method to only three of the five file types used in the study. The final testing phase revealed that implementing proposed standard controls of method operations reduced the potential systematic errors to a negligible level when using the image stream hashing method for content verification. The validation study concluded that examiners could use the image stream hashing method for forensic science only by implementing error mitigation techniques that utilize the proposed standard controls of method operations.
Heterologous production of rhamnolipids in Pseudomonas chlororaphis subsp chlororaphis ATCC 9446 based on the endogenous production of N‐acyl‐homoserine lactones
Authors: González‐Valdez Abigail , Escalante Adelfo , Soberón‐Chávez Gloria 
Published: December 2023

AbstractRhamnolipids (RL) are biosurfactants naturally produced by the opportunistic pathogen Pseudomonas aeruginosa. Currently, RL are commercialized for various applications and produced by Pseudomonas putida due to the health risks associated with their large‐scale production by P. aeruginosa. In this work, we show that RL containing one or two rhamnose moieties (mono‐RL or di‐RL, respectively) can be produced by the innocuous soil‐bacterium Pseudomonas chlororaphis subsp chlororaphis ATCC 9446 at titres up to 66 mg/L (about 86% of the production of P. aeruginosa PAO1 in the same culture conditions). The production of RL depends on the expression of P. aeruginosa PAO1 genes encoding the enzymes RhlA, RhlB and RhlC. These genes were introduced in a plasmid, together with a transcriptional regulator (rhlR) forming part of the same operon, with and without RhlC. We show that the activation of rhlAB by RhlR depends on its interaction with P. chlororaphis endogenous acyl‐homoserine lactones, which are synthetized by either PhzI or CsaI autoinducer synthases (producing 3‐hydroxy‐hexanoyl homoserine lactone, 3OH‐C6‐HSL, or 3‐oxo‐hexanoyl homoserine lactone, 3O‐C6‐HSL, respectively). P. chlororaphis transcriptional regulator couple with 3OH‐C6‐HSL is the primary activator of gene expression for phenazine‐1‐carboxylic acid (PCA) and phenazine‐1‐carboxamide (PCN) production in this soil bacterium. We show that RhlR coupled with 3OH‐C6‐HSL or 3O‐C6‐HSL promotes RL production and increases the production of PCA in P. chlororaphis. However, PhzR/3OH‐C6‐HSL or CsaR/3O‐C6‐HSL cannot activate the expression of the rhlAB operon to produce mono‐RL. These results reveal a complex regulatory interaction between RhlR and P. chlororaphis quorum‐sensing signals and highlight the biotechnology potential of P. chlororaphis ATCC 9446 expressing P. aeruginosa rhlAB‐R or rhlAB‐R‐C for the industrial production of RL.
Dysbiosis of lower respiratory tract microbiome are associated with proinflammatory states in non‐small cell lung cancer patients
Authors: Li Yangqian , Rao Guanhua , Zhu Guonian , Cheng Cheng , Yuan Lijuan , Li Chengpin , Gao Jianpeng , Tang Jun , Wang Zhoufeng , Li Weimin 
Published: December 2023

AbstractBackgroundThe lung has a sophisticated microbiome, and respiratory illnesses are greatly influenced by the lung microbiota. Despite the fact that numerous studies have shown that lung cancer patients have a dysbiosis as compared to healthy people, more research is needed to explore the association between the microbiota dysbiosis and immune profile within the tumor microenvironment (TME).MethodsIn this study, we performed metagenomic sequencing of tumor and normal tissues from 61 non‐small cell lung cancer (NSCLC) patients and six patients with other lung diseases. In order to characterize the impact of the microbes in TME, the cytokine concentrations of 24 lung tumor and normal tissues were detected using a multiple cytokine panel.ResultsOur results showed that tumors had lower microbiota diversity than the paired normal tissues, and the microbiota of NSCLC was enriched in Proteobacteria, Firmicutes, and Actinobacteria. In addition, proinflammatory cytokines such as IL‐8, MIF, TNF‐ α, and so on, were significantly upregulated in tumor tissues.ConclusionWe discovered a subset of bacteria linked to host inflammatory signaling pathways and, more precisely, to particular immune cells. We determined that lower airway microbiome dysbiosis may be linked to the disruption of the equilibrium of the immune system causing lung inflammation. The spread of lung cancer may be linked to specific bacteria.
Aging in the dermis: Fibroblast senescence and its significance
Authors: Zhang Jing , Yu Haoyue , Man Mao‐Qiang , Hu Lizhi 
Published: December 2023

AbstractSkin aging is characterized by changes in its structural, cellular, and molecular components in both the epidermis and dermis. Dermal aging is distinguished by reduced dermal thickness, increased wrinkles, and a sagging appearance. Due to intrinsic or extrinsic factors, accumulation of excessive reactive oxygen species (ROS) triggers a series of aging events, including imbalanced extracellular matrix (ECM) homeostasis, accumulation of senescent fibroblasts, loss of cell identity, and chronic inflammation mediated by senescence‐associated secretory phenotype (SASP). These events are regulated by signaling pathways, such as nuclear factor erythroid 2‐related factor 2 (Nrf2), mechanistic target of rapamycin (mTOR), transforming growth factor beta (TGF‐β), and insulin‐like growth factor 1 (IGF‐1). Senescent fibroblasts can induce and accelerate age‐related dysfunction of other skin cells and may even cause systemic inflammation. In this review, we summarize the role of dermal fibroblasts in cutaneous aging and inflammation. Moreover, the underlying mechanisms by which dermal fibroblasts influence cutaneous aging and inflammation are also discussed.
Elevational patterns of species richness and community structure of understorey birds in an East African montane forest
Authors: Wambugu Geoffrey M. , Amakobe Bernard , Şekercioğlu Çağan H. , Githiru Mwangi 
Published: December 2023

AbstractMt. Kasigau is the northeastern most of the Eastern Arc Mountains global hotspot and harbours some endemic and threatened species, but little is known about bird community changes along its elevational gradient. We assessed the relationship between bird biodiversity metrics, season, human disturbance, elevation and temperature using mist‐netting data collected bi‐annually over a 10‐year period. Birds were sampled along the mountain's elevational gradient at four elevation levels (858, 1104, 1321 and 1547 m). Bird richness, diversity and evenness decreased with increasing altitude in both dry and wet seasons. Bird abundance declined with increasing elevation for the lower three elevation levels but peaked at the highest elevation. All diversity metrics were higher in the wet season compared to the dry season across all the years. Elevation had a greater effect on species assemblages than season, disturbance and temperature. Temperature had significant effects on abundance, diversity and richness, while disturbance had significant effects on diversity, evenness and richness. We conclude that bird assemblages in Mt. Kasigau are strongly shaped by elevational changes, while temperature and disturbance constitute important factors influencing bird conservation in the face of global warming. Our study highlights that elevation, disturbance and temperature influence bird assemblages along tropical elevational gradients.
Biologic use is not associated with postoperative complications in patients with Crohn's disease undergoing stoma reversion
Authors: Sun Zhenya , Song Tianrun , Guo Zhen , Cao Lei , Zhu Weiming , Li Yi 
Published: December 2023

AbstractPurposeStoma creation is a common procedure in patients with Crohn's disease (CD), and early prophylaxis with biologics is recommended for high‐risk patients. However, the effect of biologic exposure on morbidity after stoma closure remains unknown. Therefore, this study aimed to investigate the impact of biologic use on the occurrence of complications in CD patients following stoma closure.MethodsConsecutive patients diagnosed with CD who underwent ileostomy reversal at a tertiary care centre between 1 January 2013 and 1 December 2021, were included in the study. The primary outcome was the occurrence of 90‐day postoperative complications.ResultsThe study included 347 eligible patients who underwent ileostomy reversal. There was no significant difference in terms of infectious complications, overall complications or length of postoperative stay between the biologic and non‐biologic groups. Multivariate logistic regression analysis identified several predictors of postoperative morbidity, including preoperative haemoglobin levels below 100 g/L, CRP levels above 10 mg/L, anastomotic site, ileostomy‐related infectious complications and albumin levels below 35 g/L.ConclusionsThis study demonstrated that the use of biologics is not associated with adverse outcomes. However, such as high CRP levels, ileostomy‐related infectious complications, hypoproteinemia, and hemoglobinemia, should be optimized prior to surgery to reduce postoperative morbidities.
TGF‐β signaling promotes desmoid tumor formation via CSRP2 upregulation
Authors: Li Yu , Fujishita Teruaki , Mishiro‐Sato Emi , Kojima Yasushi , Niu Yanqing , Taketo Makoto Mark , Urano Yuya , Sakai Tomohisa , Enomoto Atsushi , Nishida Yoshihiro , Aoki Masahiro 
Published: December 2023

AbstractDesmoid tumors (DTs), also called desmoid‐type fibromatoses, are locally aggressive tumors of mesenchymal origin. In the present study, we developed a novel mouse model of DTs by inducing a local mutation in the Ctnnb1 gene, encoding β‐catenin in PDGFRA‐positive stromal cells, by subcutaneous injection of 4‐hydroxy‐tamoxifen. Tumors in this model resembled histologically clinical samples from DT patients and showed strong phosphorylation of nuclear SMAD2. Knockout of SMAD4 in the model significantly suppressed tumor growth. Proteomic analysis revealed that SMAD4 knockout reduced the level of Cysteine‐and‐Glycine‐Rich Protein 2 (CSRP2) in DTs, and treatment of DT‐derived cells with a TGF‐β receptor inhibitor reduced CSRP2 RNA levels. Knockdown of CSRP2 in DT cells significantly suppressed their proliferation. These results indicate that the TGF‐β/CSRP2 axis is a potential therapeutic target for DTs downstream of TGF‐β signaling.
Exploring the mechanism of bioactive components of Prunella vulgaris L. in treating hepatocellular carcinoma based on network pharmacology
Authors: Tu Huahua , Feng Yanqing , Wang Wei , Zhou Huadong , Cai Qinghe , Feng Yong 
Published: December 2023

AbstractIn traditional Chinese Medicine, Prunella vulgaris L. (PVL) is potentially effective in the treatment of some human malignancies including hepatocellular carcinoma (HCC). However, the detailed mechanism of action remains unclear. The purpose of this study was to decipher the constitutes of the bioactive ingredients of PVL, and its mechanism against HCC using network pharmacology and in vitro experiments. The bioactive components of PVL were obtained by Traditional Chinese Medicine System Pharmacology Database and Analysis platform database, and the targets of bioactive components of PVL was investigated by Swiss Target Prediction database. HCC related targets were obtained from GEO database, GeneCards database and DisGeNET database, and the gene ontology function annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted for annotating the biological function of gene targets. A protein–protein interaction network was constructed using STRING database. Molecular docking of key bioactive ingredients was performed using AutoDock Vina. Cell proliferation and apoptosis were detected by cell counting kit‐8 and flow cytometry, respectively. The expression level of the target genes of PI3K/Akt pathway were detected by qPCR. In the present work, 11 bioactive components of PVL were screened out, which acted on 177 potential targets. In addition, 13,517 genes were strongly associated with HCC pathogenesis, of which 158 targets are overlapped with PVL's targets. KEGG results identified 39 signaling pathways closely associated with the 158 targets. Molecular docking showed that the main bioactive components of PVL, kaempferol, morin, quercetin, luteolin, and spinasterol, had good binding activity with the core proteins in cancer biology such as AKT1, EGFR, SRC, ESR1, and PPARG. In vitro assays showed that quercetin, one of the main components of PVL extracts effectively inhibited HCC cell proliferation, and promoted apoptosis, which may be associated with PI3K/AKT signaling pathway. In summary, PVL may regulate HCC progression by regulating core targets such as AKT1, EGFR, SRC, ESR1, and PPARG, and acting on PI3K‐Akt signaling pathway.
Relations between early majority language and socioemotional development in children with different language backgrounds
Authors: Huang Wei , Weinert Sabine , Volodina Anna 
Published: December 2023

AbstractThis study explored whether the directionality of the relation between majority language and various facets of socioemotional development (three to 5 years old) differs between children with different language backgrounds. 12,951 children (49% girls; 85% White, 6% Pakistani and Bangladeshi, 3% Black, 3% Mix, 2% Indian) from the British Millennium Cohort Study (2001–2006) were included in two‐time‐point cross‐lagged analyses. Models controlling for important covariates found a bidirectional association for monolinguals (βs = .05, −.07, −.04), a unidirectional effect of majority language on socioemotional difficulties for dual language learners (DLLs) speaking English and minority language(s) at home (β = .14), and a unidirectional effect of socioemotional strength on majority language for DLLs speaking only minority language(s) at home (β = −.17).
NAT10‐mediated ac4C modification promotes ectoderm differentiation of human embryonic stem cells via acetylating NR2F1 mRNA
Authors: Ge Junbang , Wang Zhaoxia , Wu Ji 
Published: December 2023

AbstractCell fate determination in mammalian development is complex and precisely controlled and accumulating evidence indicates that epigenetic mechanisms are crucially involved. N4‐acetylcytidine (ac4C) is a recently identified modification of messenger RNA (mRNA); however, its functions are still elusive in mammalian. Here, we show that N‐acetyltransferase 10 (NAT10)‐mediated ac4C modification promotes ectoderm differentiation of human embryonic stem cells (hESCs) by acetylating nuclear receptor subfamily 2 group F member 1 (NR2F1) mRNA to enhance translation efficiency (TE). Acetylated RNA immunoprecipitation sequencing (acRIP‐seq) revealed that levels of ac4C modification were higher in ectodermal neuroepithelial progenitor (NEP) cells than in hESCs or mesoendoderm cells. In addition, integrated analysis of acRIP‐seq and ribosome profiling sequencing revealed that NAT10 catalysed ac4C modification to improve TE in NEP cells. RIP‐qRT‐PCR analysis identified an interaction between NAT10 and NR2F1 mRNA in NEP cells and NR2F1 accelerated the nucleus‐to‐cytoplasm translocation of yes‐associated protein 1, which contributed to ectodermal differentiation of hESCs. Collectively, these findings point out the novel regulatory role of ac4C modification in the early ectodermal differentiation of hESCs and will provide a new strategy for the treatment of neuroectodermal defects diseases.