bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can regional environmental quality improve green innovation performance? an empirical analysis from China
Authors: Ding Zijing , Li Chen 
Published: November 2023

Introduction: Green innovation is an important driving force for reducing pollution and achieving high-quality development. Environmental factors are important external variables that affect innovation and are crucial to innovation development. There is a close relationship between environmental quality and green innovation performance. This paper takes the single environmental factor and combination of environmental factors of environmental quality heterogeneity as the explanatory variables, the traffic scale, economic scale, industrial scale and consumption scale as the control variables, and the per capita GDP of each city as the threshold variable, and calculates the impact of the single environmental factor and combination of environmental quality factors on the green innovation performance of 286 cities in China under different per capita GDP thresholds.Methods: We used Data Envelopment Analysis (DEA) and Threshold Regression model to measure the relationship between environmental quality and green innovation.Results: 1) under different thresholds, a single environmental factor has different impacts on the comprehensive level of innovation drive in Chinese cities. Comparing the single environmental factor under different threshold values of per capita GDP, when the per capita GDP is low, attention should be paid to improving the centralized treatment rate of urban sewage treatment plants and the comprehensive utilization rate of general industrial solid waste; When the per capita GDP is high, the harmless treatment rate of domestic waste, the centralized treatment rate of sewage treatment plants, the green coverage rate of the built-up area, and the green area can all have different promotion effects on the driving capacity of cities along the line. 2) Under different thresholds, the elasticity coefficient of the total ecological environment, the total ecological environment has a relatively obvious promoting effect on the innovation-driven development of cities along the line, but this promoting effect shows a further weakening trend with the increase of per capita GDP.Conclusion: This study helps to explain environmental quality and green innovation, which is important for promoting sustainable economic development. The government should control environmental pollution and introduce laws and policies to ensure innovation.
More losses than gains? Distribution models predict species-specific shifts in climatic suitability for European beech forest herbs under climate change
Authors: Kermavnar Janez , Kutnar Lado , Marinšek Aleksander 
Published: November 2023

IntroductionHerbaceous plant species constitute an essential element of the flora of European beech (Fagus sylvatica) forests. There is increasing evidence that rapidly changing climate is likely to modify the spatial distribution of plant species. However, we lack understanding of the impact that climate change might have on beech forest herbs across the European continent. We investigated the possible effects of predicted increasing rates of global warming and altered precipitation regimes on 71 forest herbs closely associated with beech forests, but with varying biogeographic and climatic niche attributes.MethodsBy using a total of 394,502 occurrence records and an ensemble of species distribution models (SDMs), we quantified the potential current distribution and future (2061-2080) range shifts in climatic suitability (expressed as occurrence probability, OP) according to two climate change scenarios (moderate SSP2-4.5 and severe SSP5-8.5).ResultsOverall, precipitation of the warmest quarter and temperature seasonality were the most influential predictors in shaping current distribution patterns. For SSP5-8.5 scenario, all studied species experienced significant reductions (52.9% on average) in the total size of highly suitable areas (OP &gt;0.75). However, the magnitude and directions of changes in the climatic suitability were highly species-specific; few species might even increase OP in the future, particularly in case of SSP2-4.5 scenario. The SDMs revealed the most substantial decline of climatic suitability at the trailing edges in southern Europe. We found that climatic suitability is predicted to show unidirectional northward shift and to move toward higher elevations. The gain/loss ratio was generally higher for narrow-ranged species compared to widespread taxa.DiscussionOur findings are contextualized with regards to potential confounding factors (dispersal limitation, microclimatic buffering) that may mitigate or accelerate climate change impacts. Given the low long-distance migration ability, many beech forest herbs are unlikely to track the velocity with which macroclimatic isotherms are moving toward higher latitudes, making this species group particularly vulnerable to climate change.
Informing climate adaptation strategies using ecological simulation models and spatial decision support tools
Authors: Furniss Tucker J. , Povak Nicholas A. , Hessburg Paul F. , Salter R. Brion , Duan Zhuoran , Wigmosta Mark 
Published: November 2023

IntroductionForest landscapes offer resources and ecosystem services that are vital to the social, economic, and cultural well-being of human communities, but managing for these provisions can require socially and ecologically relevant trade-offs. We designed a spatial decision support model to reveal trade-offs and synergies between ecosystem services in a large eastern Cascade Mountain landscape in Washington State, USA.MethodsWe used process-based forest landscape (LANDIS-II) and hydrology (DHSVM) models to compare outcomes associated with 100 years of simulated forest and wildfire dynamics for two management scenarios,Wildfire only and Wildfire + Treatments. We then examined the strength and spatial distribution of potential treatment effects and trends in a set of resources and ecosystem services over the simulation period.ResultsWe found that wildfire area burned increased over time, but some impacts could be mitigated by adaptation treatments. Treatment benefits were not limited to treated areas. Interestingly, we observed neighborhood benefits where fire spread and severity were reduced not only in treated patches but in adjacent patches and landscapes as well, creating potential synergies among some resource benefits and services. Ordinations provided further evidence for two main kinds of outcomes. Positive ecological effects of treatments were greatest in upper elevation moist and cold forests, while positive benefits to human communities were aligned with drier, low- and mid-elevation forests closer to the wildland urban interface.DiscussionOur results contribute to improved understanding of synergies and tradeoffs linked to adaptation and restoration efforts in fire-prone forests and can be used to inform management aimed at rebuilding resilient, climate-adapted landscapes.
Genome of Linum usitatissimum convar. crepitans expands the view on the section Linum
Authors: Dvorianinova Ekaterina M. , Pushkova Elena N. , Bolsheva Nadezhda L. , Borkhert Elena V. , Rozhmina Tatiana A. , Zhernova Daiana A. , Novakovskiy Roman O. , Turba Anastasia A. , Sigova Elizaveta A. , Melnikova Nataliya V. , Dmitriev Alexey A. 
Published: November 2023

Sequencing whole plant genomes provides a solid foundation for applied and basic studies. Genome sequences of agricultural plants attract special attention, as they reveal information on the regulation of beneficial plant traits. Flax is a valuable crop cultivated for oil and fiber. Genome sequences of its representatives are rich sources of genetic information for the improvement of cultivated forms of the plant. In our work, we sequenced the first genome of flax with the dehiscence of capsules—Linum usitatissimum convar. сrepitans (Boenn.) Dumort—on the Oxford Nanopore Technologies (ONT) and Illumina platforms. We obtained 23 Gb of raw ONT data and 89 M of 150 + 150 paired-end Illumina reads and tested different tools for genome assembly and polishing. The genome assembly produced according to the Canu—Racon ×2—medaka—POLCA scheme had optimal contiguity and completeness: assembly length—412.6 Mb, N50—5.2 Mb, L50—28, and complete BUSCO—94.6% (64.0% duplicated, eudicots_odb10). The obtained high-quality genome assembly of L. usitatissimum convar. crepitans provides opportunities for further studies of evolution, domestication, and genome regulation in the section Linum.
Effective population size of Culex quinquefasciatus under insecticide-based vector management and following Hurricane Harvey in Harris County, Texas
Authors: Huang Xinyue , Athrey Giridhar N. , Kaufman Phillip E. , Fredregill Chris , Slotman Michel A. 
Published: November 2023

Introduction:Culex quinquefasciatus is a mosquito species of significant public health importance due to its ability to transmit multiple pathogens that can cause mosquito-borne diseases, such as West Nile fever and St. Louis encephalitis. In Harris County, Texas, Cx. quinquefasciatus is a common vector species and is subjected to insecticide-based management by the Harris County Public Health Department. However, insecticide resistance in mosquitoes has increased rapidly worldwide and raises concerns about maintaining the effectiveness of vector control approaches. This concern is highly relevant in Texas, with its humid subtropical climate along the Gulf Coast that provides suitable habitat for Cx. quinquefasciatus and other mosquito species that are known disease vectors. Therefore, there is an urgent and ongoing need to monitor the effectiveness of current vector control programs.Methods: In this study, we evaluated the impact of vector control approaches by estimating the effective population size of Cx. quinquefasciatus in Harris County. We applied Approximate Bayesian Computation to microsatellite data to estimate effective population size. We collected Cx. quinquefasciatus samples from two mosquito control operation areas; 415 and 802, during routine vector monitoring in 2016 and 2017. No county mosquito control operations were applied at area 415 in 2016 and 2017, whereas extensive adulticide spraying operations were in effect at area 802 during the summer of 2016. We collected data for eighteen microsatellite markers for 713 and 723 mosquitoes at eight timepoints from 2016 to 2017 in areas 415 and 802, respectively. We also investigated the impact of Hurricane Harvey’s landfall in the Houston area in August of 2017 on Cx. quinquefasciatus population fluctuation.Results: We found that the bottleneck scenario was the most probable historical scenario describing the impact of the winter season at area 415 and area 802, with the highest posterior probability of 0.9167 and 0.4966, respectively. We also detected an expansion event following Hurricane Harvey at area 802, showing a 3.03-fold increase in 2017.Discussion: Although we did not detect significant effects of vector control interventions, we found considerable influences of the winter season and a major hurricane on the effective population size of Cx. quinquefasciatus. The fluctuations in effective population size in both areas showed a significant seasonal pattern. Additionally, the significant population expansion following Hurricane Harvey in 2017 supports the necessity for post-hurricane vector-control interventions.
The transcriptomics profiling of blood CD4 and CD8 T-cells in narcolepsy type I
Authors: Khajavi Leila , Nguyen Xuan-Hung , Queriault Clémence , Chabod Marianne , Barateau Lucie , Dauvilliers Yves , Zytnicki Matthias , Liblau Roland 
Published: November 2023

BackgroundNarcolepsy Type I (NT1) is a rare, life-long sleep disorder arising as a consequence of the extensive destruction of orexin-producing hypothalamic neurons. The mechanisms involved in the destruction of orexin neurons are not yet elucidated but the association of narcolepsy with environmental triggers and genetic susceptibility (strong association with the HLA, TCRs and other immunologically-relevant loci) implicates an immuno-pathological process. Several studies in animal models and on human samples have suggested that T-cells are the main pathogenic culprits.MethodsRNA sequencing was performed on four CD4 and CD8 T-cell subsets (naive, effector, effector memory and central memory) sorted by flow cytometry from peripheral blood mononuclear cells (PBMCs) of NT1 patients and HLA-matched healthy donors as well as (age- and sex-) matched individuals suffering from other sleep disorders (OSD). The RNAseq analysis was conducted by comparing the transcriptome of NT1 patients to that of healthy donors and other sleep disorder patients (collectively referred to as the non-narcolepsy controls) in order to identify NT1-specific genes and pathways.ResultsWe determined NT1-specific differentially expressed genes, several of which are involved in tubulin arrangement found in CD4 (TBCB, CCT5, EML4, TPGS1, TPGS2) and CD8 (TTLL7) T cell subsets, which play a role in the immune synapse formation and TCR signaling. Furthermore, we identified genes (GZMB, LTB in CD4 T-cells and NLRP3, TRADD, IL6, CXCR1, FOXO3, FOXP3 in CD8 T-cells) and pathways involved in various aspects of inflammation and inflammatory response. More specifically, the inflammatory profile was identified in the “naive” subset of CD4 and CD8 T-cell.ConclusionWe identified NT1-specific differentially expressed genes, providing a cell-type and subset specific catalog describing their functions in T-cells as well as their potential involvement in NT1. Several genes and pathways identified are involved in the formation of the immune synapse and TCR activation as well as inflammation and the inflammatory response. An inflammatory transcriptomic profile was detected in both “naive” CD4 and CD8 T-cell subsets suggesting their possible involvement in the development or progression of the narcoleptic process.
Comprehensive analysis of the association between inflammation indexes and complications in patients undergoing pancreaticoduodenectomy
Authors: Ma Minghua , Li Guo , Zhou Baoyong , Li Kaili , Wu Zhongjun , Kong Lingwang , Liu Maoyun , Liu Miao , Zhang Cheng , Yu Huarong , Wang Shuaiqi , Huang Zuotian , Zong Kezhen 
Published: November 2023

BackgroundDuring clinical practice, routine blood tests are commonly performed following pancreaticoduodenectomy (PD). However, the relationship between blood cell counts, inflammation-related indices, and postoperative complications remains unclear.MethodWe conducted a retrospective study, including patients who underwent PD from October 2018 to July 2023 at the First Hospital of Chongqing Medical University, and compared baseline characteristics and clinical outcomes among different groups. Neutrophil count (NC), platelet count (PLT), lymphocyte count (LC), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and the product of platelet count and neutrophil count (PPN) were derived from postoperative blood test results. We investigated the association between these indicators and outcomes using multivariable logistic regression and restricted cubic spline analysis. The predictive performance of these indicators was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and decision curve analysis (DCA).ResultA total of 232 patients were included in this study. Multivariate logistic regression and restricted cubic spline analysis showed that all indicators, except for PLT, were associated with clinical postoperative pancreatic fistula (POPF). SII, NLR, and NC were linked to surgical site infection (SSI), while SII, NLR, and PLR were correlated with CD3 complication. PLT levels were related to postoperative hemorrhage. SII (AUC: 0.729), NLR (AUC: 0.713), and NC (AUC: 0.706) effectively predicted clinical POPF.ConclusionIn patients undergoing PD, postoperative inflammation-related indices and blood cell counts are associated with various complications. NLR and PLT can serve as primary indicators post-surgery for monitoring complications.
Randomized controlled trial on the effects of mindfulness-based respiratory decompression therapy in claustrophobic patients undergoing MRI inspection
Authors: Zhou Yi , Cao Yanqing , Xu Shan , Li Sijin , Liang Yidan , Zhang Wei , Xiao Yunping 
Published: November 2023

BackgroundClaustrophobia is a psychological disease. It is estimated to occur in 2.1–14.3% of all magnetic resonance imaging (MRI) examinations. Mindfulness decompression is an effective means to treat and reduce fear and anxiety. There is a rare report on the application of mindfulness-based stress reduction therapy in the magnetic resonance examinations of patients with claustrophobia to date.PurposeThe purpose of this study is to explore the intervention effect of mindfulness respiratory decompression therapy on the MRI inspection of patients with claustrophobia.MethodsA total of 86 patients with claustrophobia requiring MRI in our hospital from January 2018 to December 2020 were divided into two groups. The control group was given routine psychological nursing, and the observation group was given a mindfulness breathing technique on the basis of the control group. Before and after the intervention, we compared the intervention effect, satisfaction with nurses’ psychological intervention technique, severe autonomic nervous symptoms during the examination, self-rating anxiety scale (SAS) scores, and profile of mood states revised (POMS-R) scores.ResultsThe total effective rate of intervention in the observation group was 90.90%, which was significantly higher (χ2 = 6.857, p = 0.00004) than that in the control group (26.19%). Severe autonomic nervous symptoms in the observation group were significantly lower than those in the control group (p &lt; 0.05). After the intervention, SAS scores and POMS-R scores in the observation group decreased with statistical significance (p &lt; 0.05).ConclusionMindfulness respiratory decompression therapy can effectively help claustrophobic patients complete an MRI examination, which may be worthy of wide promotion and application in the clinic.
The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials
Authors: Liu Xiaoye , Qi Manli 
Published: November 2023

BackgroundThe treatment of condyloma acuminatum (CA), especially the very persistent and recurrent CA, is currently the focus of our research. Immunotherapies have recently been shown to be well-tolerated and effective in treating warts, particularly refractory warts. However, there is still a lack of corresponding evidence-based medical evidence on the effectiveness of different immunotherapies in treating warts. The difference between network meta-analysis and meta-analysis is that network meta-analysis can be used to compare multiple treatments by combining direct and indirect evidence to assess the interrelationship between all treatments. We intend to compare the efficacy of different treatments for CA using a network meta-analysis.MethodsPubMed, Cochrane Library and Embase from inception to June 1st, 2023 were searched using a computer. All articles on immunotherapies for CA were included. Stata MP17.0 software was used for data analyses.ResultsA total of 8 randomly-controlled trials involving 493 patients were included. Result showed that all treatment measures had a significant efficacy compared with the regular saline group (BCG (bacillus Calmette-Guérin vaccine) OR = 96.00, 95%CI: 10.35–890.58; MMR (measle, mumps and rubella vaccine) OR = 29.69, 95%CI: 7.47–118.04; Candida antigens OR = 27.34, 95%CI: 8.64–86.52; PPDs (purified protein derivatives) OR = 23.33, 95%CI: 6.75–80.60; VD3 OR = 21.36, 95%CI: 4.34–105.16 and purified protein derivatives (general) OR = 13.14, 95%CI: 3.38–51.12). The area under the curve (SUCRA) ranking results showed that the bacillus Calmette-Guérin vaccine had the highest total efficiency, which was 88.2%, with the rest in the order of measle, mumps and rubella vaccine, which was 68.9%, Candida antigens, which was 63.6%, purified protein derivatives, which was 52.9%, vitamin D3, which was 49.0%, purified protein derivatives (general), which was 27.4%, and saline, which was 0%.ConclusionIn summary, we found that the bacillus Calmette-Guérin vaccine was superior to other treatments in terms of efficacy according to the SUCRA value.
Association between the sarcopenia index and abnormal liver function in the adult population in the United States: a cross-sectional study
Authors: Xu Jian , Xu Zhi-Xiang , Yang Qi-Fan , Zhuang Jing , Zhu Xin , Yao Jun 
Published: November 2023

BackgroundThe objective of this study was to explore the association between the sarcopenia index and abnormal liver function in adult individuals in the United States.MethodologyThis study employed a rigorous cross-sectional analysis of data derived from the National Health and Nutrition Examination Survey (NHANES) conducted between 2017 and 2018. The primary objective was to investigate the correlation between the sarcopenia index and abnormal liver function. To achieve this, an advanced multivariate regression model was utilized, allowing for comprehensive analysis and meticulous adjustment of relevant variables. To ensure the robustness of the findings, a visually appealing smooth curve was constructed, and a two-stage regression model was applied for validation. Additionally, a detailed gender-stratified analysis was conducted to further explore the association between the sarcopenia index and abnormal liver function within distinct subgroups.ResultsThrough our rigorous participant selection process, a total of 1756 individuals were included in the study. The meticulously adjusted multivariate regression model revealed a significant negative association between the sarcopenia index and abnormal liver function, with an adjusted odds ratio (OR) of 0.73 and a 95% confidence interval (CI) ranging from 0.63 to 0.86. The robustness of this association was further supported by the visually appealing smooth curve plot. Moreover, in the gender-stratified subgroup analysis, after meticulous adjustment for confounding factors, notable differences in this association emerged (males: OR = 0.8, 95% CI: 0.66–0.98; females: OR = 0.61, 95% CI: 0.47–0.79).ConclusionThis cross-sectional study yields robust evidence indicating a negative correlation between the sarcopenia index and abnormal liver function, predominantly observed among females.