bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Low-Dose Aspirin Management for Planned Clipping Surgery: When, How Long, and With What Precautions?
Authors: Han Hyun Jin , Kim Junhyung , Jang Chang Ki , Kim Jung-Jae , Park Keun Young , Park Sang Kyu , Chung Joonho , Kim Yong Bae 
Published: October 2023

BACKGROUND AND OBJECTIVE:
Perioperative low-dose aspirin (ASA) management for open craniotomy surgery lacked information. We analyze to establish the perioperative ASA strategy to minimize both hemorrhagic and thromboembolic complications.

METHODS:
The investigators designed a multicenter retrospective study, which included patients scheduled to have clipping surgery for unruptured intracranial aneurysm. The incidence and risk factors were analyzed for postoperative hemorrhagic complications and major cardio- and cerebrovascular events (MACCEs) within 1 month postoperation.

RESULTS:
This study included 503 long-term ASA users of 3654 patients at three tertiary centers. The incidence of hemorrhagic complications and MACCEs was 7.4% (37/503) and 8.8% (44/503), respectively. Older age (>70 years, odds ratio [OR]: 2.928, 95% CI [1.337-6.416]), multiple aneurysms operation (OR: 2.201, 95% CI [1.017-4.765]), large aneurysm (>10 mm, OR: 4.483, 95% CI [1.485-13.533]), and ASA continuation (OR: 2.604, 95% CI [1.222-5.545]) were independent risk factors for postoperative hemorrhagic complications. Intracranial hemorrhage was the only type of hemorrhagic complication that increased in the ASA continuation group (10.6% vs 2.9%, P = .001). Between the ASA continuation and discontinuation groups, the overall incidence of MACCEs was not significantly different (log-rank P = .8). In the subgroup analysis, ASA discontinuation significantly increased the risk of MACCEs in the secondary prevention group (adjusted hazard ratio: 2.580, 95% CI [1.015-6.580]).

CONCLUSION:
ASA continuation increased the risk of postoperative intracranial hemorrhage. Simultaneously, ASA discontinuation was the major risk factor for postoperative MACCEs in the high-risk group. Without evidence of intracranial hemorrhage, early ASA resumption was indicated (a total cessation duration <7-10 days) in the secondary prevention group.
KDM5-mediated activation of genes required for mitochondrial biology is necessary for viability in Drosophila
Authors: Rogers Michael F. , Marshall Owen J. , Secombe Julie 
Published: October 2023

ABSTRACT
Histone-modifying proteins play important roles in the precise regulation of the transcriptional programs that coordinate development. KDM5 family proteins interact with chromatin through demethylation of H3K4me3 as well as demethylase-independent mechanisms that remain less understood. To gain fundamental insights into the transcriptional activities of KDM5 proteins, we examined the essential roles of the single Drosophila Kdm5 ortholog during development. KDM5 performs crucial functions in the larval neuroendocrine prothoracic gland, providing a model to study its role in regulating key gene expression programs. Integrating genome binding and transcriptomic data, we identify that KDM5 regulates the expression of genes required for the function and maintenance of mitochondria, and we find that loss of KDM5 causes morphological changes to mitochondria. This is key to the developmental functions of KDM5, as expression of the mitochondrial biogenesis transcription factor Ets97D, homolog of GABPα, is able to suppress the altered mitochondrial morphology as well as the lethality of Kdm5 null animals. Together, these data establish KDM5-mediated cellular functions that are important for normal development and could contribute to KDM5-linked disorders when dysregulated.
Case Report: Introduction of antibiotic releasing calcium sulfate bone void filler beads (Stimulan) for management of an infected cyst of the maxilla
Authors: Patil Sneha , Kambala Rajanikanth , Bhola Nitin , Vishnani Rozina 
Published: October 2023

Radicular cysts are the most common odontogenic cyst arising from epithelial cell rests of Malassez in the periodontal ligament and proliferate peripherally as a result of inflammation caused by infection at the root apices. They slowly grow apically causing bone resorption and displacement of the adjacent teeth which radiographically is seen as a radiolucent unilocular lesion. Management of such bone defects can be done by using various bone graft substitutes such as autogenous, allografts, xenografts and alloplasts. Taking account of the benefits of using synthetic bone graft substitutes, the following case represents the successful management of a radicular cyst, which includes endodontic treatment and cyst enucleation, chemical cauterization followed by introduction of antibiotic (Vancomycin) releasing calcium sulfate filler beads into the defect.
Identification of high-performing antibodies for SPARC-related modular calcium-binding protein 1 (SMOC-1) for use in Western Blot and immunoprecipitation
Authors: Ayoubi Riham , González Bolívar Sara , Nicouleau Michael , Southern Kathleen , Laflamme Carl ,   NeuroSGC/YCharOS/EDDU collaborative group
Published: October 2023

SPARC-related modular calcium-binding protein 1, otherwise known as SMOC-1, is a secreted glycoprotein involved in various cell biological processes including cell-matrix interactions, osteoblast differentiation, embryonic development, and homeostasis. SMOC-1 was found to be elevated in asymptomatic Alzheimer’s disease (AD) patient cortex as well as being enriched in amyloid plaques and in AD patient cerebrospinal fluid, arguing for SMOC-1 as a promising biomarker for AD. Having access to high-quality SMOC-1 antibodies is crucial for the scientific community. In this study, we characterized seven SMOC-1 commercial antibodies for Western blot and immunoprecipitation, using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. We identified successful antibodies and encourage readers to use this report as a guide to select the most appropriate antibody for their specific needs.
Curved OLED-based NLOS optical camera communications links
Authors: Teli Shivani Rajendra , Matus Vicente , Aguiar Carmen Lidia , Perez-Jimenez Rafael , Ghassemlooy Zabih , Zvanovec Stanislav 
Published: October 2023

In this paper, for the first time, to the best of our knowledge, we experimentally demonstrate the use of a curved organic light emitting diode (OLED) as a transmitter (Tx) in the non-line-of-sight (NLOS) optical camera communication (OCC) link for an indoor environment using a camera as a receiver. The proposed NLOS-OCC scheme is evaluated for the signal-to-noise ratio (SNR) and the reception success rates Rrs under key photographic and communication parameters, including exposure times texp and gain values G
v
, as well as the transmission frequency f
s
and the distance L. The SNR analysis is performed using a binary classification procedure based on a Gaussian mixture model for the first time, to the best of our knowledge, for OLED-based NLOS-OCC links. We also derive and demonstrate that the effect of G
v
on the SNR with respect to L is minimal based on the pixel illumination model. The initial analysis suggests that, for a wall reflector-based NLOS-OCC link that is 2 m long, the SNR and Rrs increase by 1 dB and 4% (83–87%) for f
s
of 600 Hz, with an increase in texp of 1000–1500 µs and G
v
of 25–45 dB.
Heat and force coupling analysis during precision glass molding of free-form optical elements
Authors: Zhang Zeguang , Liu Yue , Xue Changxi 
Published: October 2023

As an effective method for mass production of glass lenses, precision glass molding (PGM) technology has been mature in aspherical lens technology. However, glass molding of complex surfaces such as free-form optical elements is still in its infancy. For mass-produced glass lenses, the energy consumption is mainly concentrated on the heating stage, and the cost is also a key concern. In this paper, an XY polynomial free-form optical element is simulated by the finite element method. In view of the long heating and molding time, finite element models were established, respectively, at the optimum molding temperature and a temperature point before the optimum temperature. The stress distribution and variation trend of the two methods were analyzed, and the single cycle time of the two methods was compared. The results showed that, under the premise of the maximum stress increase of 3.91 MPa, this method reduces the heating and molding time from 1000 to 910 s, which has significant advantages in terms of time and cost.
Confocal microscopy based on dual blur depth measurement
Authors: Yuan Tao , Jiang Wei , Ye Yiqing , Hai Yongjie , Yi Dingrong 
Published: October 2023

In this paper, we propose a confocal microscopy based on dual blur depth measurement (DBCM). The first blur is defocus blur, and the second blur is artificial convolutional blur. First, the DBCM blurs the defocus image using a known Gaussian kernel and calculates the edge gradient ratio between it and the re-blurred image. Then, the axial measurement of edge positions is based on a calibration measurement curve. Finally, depth information is inferred from the edges using the original image. Experiments show that the DBCM can achieve depth measurement in a single image. In a 10×/0.25 objective, the error measured for a step sample of 4.7397 µm is 0.23 µm. The relative error rate is 4.8%.
Ultrasensitive tunable terahertz lithium niobate metasurface sensing based on bound states in the continuum
Authors: Yu Xinyao , Li Fanghao , Lang Tingting , Qin Jianyuan , Ma Xiao 
Published: October 2023

Lithium niobate’s substantial nonlinear optical and electro-optic coefficients have recently thrust it into the limelight. This study presents a thorough review of bound states in the continuum (BICs) in lithium niobate metasurfaces, also suggesting their potential for sensing applications. We propose an all-dielectric tunable metasurface that offers high Q factor resonances in the terahertz range, triggered by symmetry-protected BICs. With exceptional sensitivity to changes in the refractive index of the surrounding medium, the metasurface can reach a sensitivity as high as 947 GHz/RIU. This paves the way for ultrasensitive tunable terahertz sensors, offering an exciting path for further research.
Flexible top-illuminated organic photodetector using an ultrathin-metal-based transparent electrode
Authors: Wang Yuanhe , Li Xinyi , Liu Shihao , Zhang Letian , Xie Wenfa 
Published: October 2023

Top-illuminated structure facilitates the integration of organic photodetectors (OPDs) into high-resolution flexible wearable light detection systems by allowing the OPDs to be deposited on the bottom readout circuit. However, constructing this structure poses a challenge as it demands metallic electrodes with both high optical transparency and high electrical conductivity. But to achieve practical sheet resistances, most semitransparent metallic electrodes tend to reflect a large portion of incident light instead of allowing it to be absorbed by the photoactive layer of the OPDs. This, in turn, results in reduced photocurrent generation. To address this issue, a semiconducting germanium (Ge) film is introduced into a sliver (Ag) film, effectively reducing its reflectivity by lessening scattering. The Ge film also changes how the Ag film grows, further reducing its absorption by lowering the critical thickness needed for forming a continuous film. This approach yields a 10 nm metallic electrode with a transmittance of 70%, a reflectivity of 12%, and a sheet resistance of 35.5 Ω/□. Using this metallic electrode, flexible OPDs exhibit a high photo-to-dark current ratio of 2.9×104 and improved mechanical properties. This finding highlights the benefits of the top-illuminated structure, which effectively reduces losses caused by waveguided modes of the incident light.
The cross-cultural validation of the Beach Center Family Quality of Life Scale among persons affected by leprosy or podoconiosis in Northwest Ethiopia
Authors: Aycheh Moges Wubie , van’t Noordende Anna T. , Moges Nurilign Abebe , Schippers Alice P. 
Published: October 2023

Background
The Beach Center Family Quality of Life Scale has been developed and validated in different languages in different countries. However, this scale has not been validated in the Ethiopian Amharic language context. Therefore, this study aimed to investigate the cross-cultural validity of the Beach Center Family Quality of Life Scale, among Ethiopian families of persons affected by leprosy and podoconiosis.

Methodology
We explored the semantic equivalence, internal consistency, reproducibility, floor and ceiling effects, and interpretability of the Beach Center Family Quality of Life Scale in Amharic. A cross-sectional study was conducted after the translation and back-translation of the instrument. A total of 302 adult persons affected by leprosy or podoconiosis was asked about their level of satisfaction with their family life, using the Beach Center Family Quality of Life Scale. In addition, 50 participants were re-interviewed two weeks after the initial assessment to test the reproducibility of the scale. Participants were recruited in the East Gojjam zone of Northwest Ethiopia.

Results
The findings of this study showed that the Beach Center Family Quality of Life Scale had high internal consistency (Cronbach’s alpha of 0.913) and reproducibility (intra-class correlation coefficient of 0.857). The standard error of measurement was 3.01, which is 2.4% of the total score range. The smallest detectable change was 8.34. Confirmatory factor analysis showed adequate factor loadings and model fit indices like the original scale. The composite reliability and average variance extracted from the scale were acceptable. No floor and ceiling effects were found.

Conclusions
Our findings indicate that the Amharic version of the Beach Center Family Quality of Life Scale has adequate cultural validity to assess the family quality of life in Ethiopian families of persons affected by leprosy and podoconiosis.
Ten years follow-up of the largest oral Chagas disease outbreak: Cardiological prospective cohort study
Authors: Ruiz-Guevara Raiza , Alarcón de Noya Belkisyolé , Mendoza Iván , Rojas Cielo , Machado Iván , Díaz-Bello Zoraida , Muñoz-Calderón Arturo , Castro Julio , Noya Oscar 
Published: October 2023

Background
Chagas disease (ChD) is the most important endemy in Latin America. Some patients, develop chronic Chagasic cardiopathy (CCC) years after the acute phase. It is unknown if patients infected by the oral route have higher risk of developing early CCC.

Methods and findings
A prospective cohort study was conducted to assess morbidity and mortality during 10 years observation in 106 people simultaneously infected and treated in the largest known orally transmitted ChD outbreak in 2007. A preschooler died during the acute phase, but thereafter was no mortality associated to ChD. All acute phase findings improved in the first-year post-treatment. Each person was evaluated 8.7 times clinically, 6.4 by electrocardiogram (ECG)/Holter, and 1.7 by echocardiogram. Based on prevalence, the number of people who had any abnormalities (excluding repolarization abnormalities and atrial tachycardia which decreased) was higher than 2007, since they were found at least once between 2008–2017. However, when we evaluated incidence, except for clinical bradycardia and dizziness, it was observed that the number of new cases of all clinical and ECG findings decreased at the end of the follow-up. Between 2008–2017 there was not incidence of low voltage complex, 2nd degree AV block, long QT interval, left bundle branch block or left ventricular dysfunction that allowed the diagnosis of CCC. Total improvement prevailed over the persistence of all clinical and ECG/Holter findings, except for sinus bradycardia. Incomplete right bundle branch block, sinus bradycardia and/or T-wave inversion were diagnosed persistently in 9 children. The second treatment did not have significant influence on the incidence of clinical or ECG/Holter findings.

Conclusions
At the end of the 10-year follow-up, there were not clinical or ECG/Holter criteria for classifying patients with CCC. The incidence of arrhythmias and repolarization abnormalities decreased. However, special attention should be paid on findings that not revert as sinus bradycardia, or those diagnosed persistently in all ECG as sinus bradycardia, incomplete right bundle branch block or T-wave inversion. Early diagnosis and treatment may have contributed to the rapid improvement of these patients. In ChD follow-up studies prevalence overestimates the real dimension of abnormalities, the incidence looks as a better indicator.
COVID-19 prevention and rehabilitation related knowledge and practices among Egyptian post-COVID-19 patients
Authors: Salem Marwa Rashad , Hegazy Nelly , Abd El Fatah Shaimaa A. M. , Shahib Alaaelrahman Essam Mahmoud , Hejazi Ahmad Mohamad 
Published: October 2023

Background
Even with the mild form of COVID-19, people need to practice the proper preventive measures to achieve health, safety and control spread of infection. Few studies assessed sound disinfection and rehabilitative knowledge. This study aims to assess the self-reported, knowledge of specific disinfection measures among post-recovery COVID-19 patients and identifying the most requested knowledge items regarding the prevention and post COVID rehabilitation measures.

Methods
This is an exploratory cross-sectional study using an electronically open survey. A pre-tested e-questionnaire was employed for data assembling. The sample size was calculated and a total of 417 people completed the questionnaire. Knowledge score was calculated for preventive and disinfection measures during and after COVID 19 infection. It comprised three sections: socio-demographics, study participants’ knowledge regarding precautions, disinfection, and rehabilitation measures, as well as sources of knowledge about COVID-19.

Results
All participants infected with COVID-19 (82%) reported self-isolation for ten days after confirming the infection, with only 18% required hospitalization. Regarding the information needed by the participants, the highest requests were for the rehabilitation information after COVID-19 and preventive measures. Females under 30 years old and those with a college education or higher were significantly more likely to request rehabilitation information after COVID-19 (P-value 0.05). Nevertheless, males were significantly more interested in information regarding preventive measures; They were over 30 years old and had education below university (P-value 0.05). Participants (above 30 years old) had significantly higher knowledge of preventive and disinfection measures during and after COVID-19 infection (P = 0.030).

Conclusion
After the COVID-19 experience, most participants demonstrated a great desire for rehabilitation information and proper preventive measures. This paves the way for delivering self-management and rehabilitation knowledge and emphasizing the significance of various prevention modalities.
Subcutaneous Delivery of Diagnostics and RNAi to Primary and Metatstatic Tumors via Actively-targeted sub-50 nm (s50) Capsules.
Authors: Korman Viccie L , Nacusi Lucas , Pretti Alex J , Tobolt Diane L , Robertson J. David , Unger Gretchen 
Published: October 2023

Purpose: To investigate targeting and efficacy of s50 capsules for delivery of biotherapeutics to primary and distant tumors by subcutaneous (SQ) injection.
Methods s50 capsules comprised of a tumor-targeting Tenfibgen (TBG) shell and bearing either Dysprosium (TBGDy) or a mixture of RNAi oligonucleotides against Casein Kinase 2 (CK2) &#945; and &#945;&#8242; kinase subunits (GS-10), were synthesized by dispersion atomization (Fig.1). Two metastatic head and neck cancer (HNC) xenograft models, FaDu and SCC-47, were flank-injected into nude mice to test s50 targeting and efficacy. Specific targeting was assayed by delivering TBGDy via IV or SQ administration and measuring biodistribution. Mice were dissected and Dy content was quantitated in blood and tissues by neutron activation analysis for the isotope Dy163m. Capsule localization in tissue was documented by direct far-red fluorescence of Dy and indirect immunofluorescence of a Fab fragment “spiked” into the capsule shell. GS-10 efficacy in xenograft models was assayed by measuring growth inhibition via primary tumor weights and CK2 mRNA transcript levels by qPCR. GS-10 efficacy on distant brain and lung tumors was determined by cytokeratin-14 (K-14) expression.
Results: Biodistribution studies showed higher Dy concentration in tumor than liver for SQ routes (Fig. 2). Dy accumulation in primary tumors peaked at 48hrs post-SQ administration and was comparable to 4hrs post-IV administration (28% vs. 16% ID/g). Dy colocalizationn with capsule shell was confirmed by confocal microscopy supporting interpretation of Dy163m as capsule signal (Fig. 3). In the 30-day FaDu efficacy study, a 100 ug/kg daily (tumor-remote) SQ dose, decreased K-14, 47 and 79% in brains and lungs, respectively (n=5). In the 21-day SCC-47 model, significant growth inhibition of was observed in primary tumor weights relative to diluent and sugar capsule treatment respectively (92.8, 89.8%). CK2 RNA levels were reduced relative to sugar capsule-treated tumors (&#945;, &#945;&#8242;: 25.4%, 24.4%, n=3) while further anti-CK2 transcript activity by translational blockade, and CK2 protein downregulation was found by microscopy.
Conclusion: Subcutaneous administration of s50-delivered RNAi is a viable strategy for treatment of metastatic cancer.
Association of glycated hemoglobin with risk of pancreatic cancer in high-risk individuals based on genetic and family history.
Authors: Wu Bechien U , Chen Qiaoling , Moon Becky H , Lustigova Eva , Nielsen Erin G. , Alvarado Monica , Ahmed Syed A 
Published: October 2023

Abstract

Background:
Screening for pancreatic cancer (PC) is suggested for high-risk individuals (HRI). Additional risk factors may enhance early detection in this population.

Methods:
Retrospective cohort study among patients with germline variants and/or familial pancreatic cancer in an integrated healthcare system between 2003-2019. We calculated incidence rate (IR) by risk category and performed a nested case-control study to evaluate relationship between HbA1C and PC within 3 years prior to diagnosis(cases) or match date(controls). Cases were matched 1:4 by age, sex, and timing of HbA1c. Logistic regression was performed to assess independent association with PC.

Results:
We identified 5,931 HRIs: 1175(19.8%) familial PC, 45(0.8%) high-risk germline variants (STK11, CDKN2A), 4097(69.1%) had other germline variants (ATM, BRCA 1, BRCA 2, CASR, CDKN2A, CFTR, EPCAM, MLH1, MSH2, MSH6, PALB2, PRSS1, STK11, TP53), and 614(10.4%) had both germline variants and family history. 68 (1.1%) patients developed PC; 50% were metastatic at diagnosis. High-risk variant was associated with greatest risk of PC, IR=85.1(95% CI: 36.7-197.6)/10,000 person-years, other germline variants and FDR had IR=33 (18.4, 59.3) while IR among ≥2 FDR alone was 10.7 (6.1, 18.8). HbA1c was significantly higher among cases vs. controls (median=7.0% vs. 6.4%, p=0.02). In multivariable analysis, every 1% increase in HbA1c was associated with 36% increase in odds of PC (OR=1.36, 95% CI: 1.08-1.72). Pancreatitis was independently associated with risk of PC (OR 3.93, 95% CL1.19,12.91).

Conclusion:
Risk of PC varies among high-risk individuals. HbA1c and history of pancreatitis may be useful additional markers for early detection in this patient population.