bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Source and Reservoir Rock Petroleum Generative Potential of Early Eocene and Paleocene Sequences of the Punjab Platform Basin, Pakistan: A Geochemical and Petrophysical Approach
Authors: Ali Shah Syed Bilawal 
Published: November 2023

Abstract
––Investigating Early Eocene and Paleocene deposits within the Punjab Platform, Pakistan, involved comprehensive analysis using advanced geochemical and petrophysical techniques. This study evaluates the source potential of three formations: Nammal and Sakesar of Early Eocene age and Dungan and Ranikot of Palaeocene age. The Sakesar Formation, a reservoir rock, was evaluated through interpretation of wireline logs to estimate key petrophysical properties—porosity, water saturation, and hydrocarbon saturation. Geochemical investigations focused on total organic carbon content and Rock-Eval pyrolysis of twenty-one cutting samples from a well. These samples displayed TOC values ranging from 0.21 to 2.04 wt.% and S2 values ranging from 0.09 to 2.14 mg HC/g rock. Analysis positioned all samples within the immature window zone with Type II/III and Type III kerogen, suggesting limited generative potential. Findings suggest limited hydrocarbon generation from these formations. Petrophysical analysis indicated average porosity of 11.2%, water saturation of 32.58%, and hydrocarbon saturation of 67.42% for the Sakesar Formation, categorizing it as average to good reservoir potential. This study highlights complex geochemical and petrophysical characteristics of these formations. While Sakesar shows promising reservoir qualities, significant hydrocarbon generation potential from Nammal, Dungan, and Ranikot formations is constrained. Informed decision-making is crucial when considering these formations as hydrocarbon sources.
RUVBL1 and RUVBL2 as novel druggable DNA Damage Response regulators in the N-Myc regulatory network in neuroblastoma
Authors: Eynden Jimmy Van den , Siaw Joachim , Claeys Arne , Lai Wei-Yun , Borenäs Marcus , Hilgert Elien , Bekaert Sarah-Lee , Speleman Franki , Durinck Kaat , Hallberg Bengt , Palmer Ruth H 
Published: November 2023

Abstract
High-risk neuroblastoma (NB) accounts for about 50% of all cases. These tumours are characterized by MYCN amplification and high MYC gene expression and patients have a high relapse rate despite intensive therapies, hence the need for safer and more effective drugs. Strategies to develop inhibitors that directly target the MYC proteins have been elusive. Based on in silico molecular signature score and network analyses, we identified RUVBL2 as a key interactor of MYC. Kaplan-Meier survival and multivariate Cox regression analyses using public NB datasets demonstrated that expression of RUVBL2 and its interaction partner RUVBL1 are strong and independent predictors for both overall and event-free survival in NB patients. Using different types of NB cell lines, we experimentally demonstrated that transient knockdown of RUVBL1/2 or pharmacological inhibition using CB-6644 resulted in cell cycle arrest, cell growth arrest and a DNA Damage Response (DDR) through regulation of ATR and ATM. Additionally we confirmed that RUVBL1/2 transcriptionally regulate MYCN and MYC. Our work demonstrates that RUVBL1 and RUVBL2 are novel regulators of the DDR with therapeutic and independent prognostic potential in high-risk NB.
Placental histological differences between COVID19 infected and non-infected mothers during third trimester of pregnancy: a retrospective cohort study.
Authors: meguerian Zarouhi , Irani Jihad , chalhoub elias , samad sara El , Khalifeh Joe , Ghanem Joe , Nassar Jean , Feghali Joe , Hajal Nadim , Snaifer Elie , Anastasiades Elie 
Published: November 2023

Abstract
Background
The aim of this study is to investigate placental histological differences between Covid-19 uncomplicated pregnancies and Covid-19 infected mothers in the 3rd trimester or intrapartum.
METHODS
This was a retrospective cohort study conducted between the 28th of January 2021 and the 31st of June of the same year at Saint George University Medical Hospital. All pregnant women, whether symptomatic or not, were tested for Covid-19 infection via PCR upon presentation for delivery. We randomly collected placentas from Covid-19 uncomplicated gestations and 3rd trimester or intrapartum Covid-19 infected mothers after obtaining an informed consent. Our control population included all previously healthy mothers, singleton, term, and uncomplicated pregnancies regardless of the mode of delivery during the same period of the study. The Covid- 19 infected group had similar medical and obstetrical background only for coronavirus infection during the 3rd trimester or upon admission. Placentas of the two groups were grossly and histologically examined by a single pathologist who was blinded to the placentas of each group. Examination was based on the Amsterdam Consensus Statement guidelines.
RESULTS
A total of 22 Covid-19 positive cases and 21 Covid-19 negative cases were included. The results showed no statistical significance for any of the placental pathologies including maternal vascular malperfusion, amniotic fluid infection including maternal response and fetal response, villitis of unknown etiology, intervillositis and chorangiosis and fetal vascular malperfusion, except for the vascular ectasia, were 5 cases were identified in the Covid-19 positive group (p < 0.05).
CONCLUSION
Covid-19 infection during the 3rd trimester of pregnancy is not a risk factor for the development of placental histopathologies.
TIM-3 on myeloid cells promotes pulmonary inflammation through increased production of galectin-3
Authors: Park Eun Jung , Kim Ki Sun , Lee Chanju , Kim Hyung-Seok , Gu Su Jeong , Yoon Hee Jung , Won Su Bin , Lee Ho , Lee Yong Sun , Kim Sang Soo , Kane Lawrence 
Published: November 2023

Abstract

T cell immunoglobulin and mucin-containing molecule 3 (TIM-3) exhibits unique characteristics and functions that differ by cell type and status, but little is known about the cell-specific properties of TIM-3 in pathophysiological conditions. Here, we report that TIM-3 on myeloid cells plays essential roles in modulating lung inflammation and diseases. We found that myeloid cell-specific TIM-3 knock-in (FSF-TIM3/LysM-Cre+) mice have lower body weight and shorter lifespan than WT mice. Intriguingly, PET/CT analysis and histopathological examination revealed that the lungs of FSF-TIM3/LysM-Cre+ mice display excessive inflammation and features of disease-associated pathology. Similar features were observed in a different myeloid cell-specific TIM-3 knock-in mouse (FSF-TIM3/Cx3cr1-Cre+ mice). Bulk RNA-sequencing and flow cytometry revealed that galectin-3 levels are notably elevated in TIM-3-overexpressing lung-derived myeloid cells. Furthermore, blockade of TIM-3 ameliorated the levels of inflammation and galectin-3 in the lungs of FSF-TIM-3/LysM-Cre+/- mice. Using an LPS-induced lung inflammation model with myeloid cell-specific TIM-3 knock-out mice, we further demonstrated that the level of myeloid cell-expressed TIM-3 is closely associated with both lung inflammation and galectin-3. Collectively, our findings suggest that TIM-3 is an important regulator of myeloid cells in the lungs, and modulation of TIM-3 and galectin-3 could be of therapeutic benefit in inflammation-associated lung diseases.
Experimental investigation of the effect of stratifiers to enhance the performance of the thermal energy storage system
Authors: SELVAM LOKESH , Sivalingam Suyambazhahan , Vis Tharun Sriramalu , Vadivelu Thanigaivelan 
Published: November 2023

Abstract
The performance enhancement of the cascaded thermal energy storage system was investigated using multi-wall carbon nanotubes (MWCNT) in phase change material (PCM) with and without a stratifier at the tank's charging inlet. The circular dispersion introduced by the stratifier into the intake of the charging tank. The experimental tests were conducted with inlet temperatures of 70, 75, and 80 °C and rate of flow 1, 2, and 3 l/min. According to the analysis findings, employing the stratifier in the storage tank resulted in an effective charging time of 37 min and 50 min without the stratifier. Also, a thermogravimetric analysis (TGA) was done to determine the material's stability. In comparison to the cylindrical phase PCM capsule, the spherical phase PCM capsule had higher total energy and enthalpy, and the spherical phase PCM capsule's heat flow contours were uniform.
Investigating the evolution chain of deformation and destabilisation of anti-dip rock slopes
Authors: Ma Wenliang , Li Jinfeng , Wang Hairen , Meng Xiangzhen 
Published: November 2023

Abstract

With the continuous promotion of engineering construction in western China, it is increasingly acknowledged that the frequency and harmfulness of deformation and destabilisation of anti-dip rock slopes are comparable to those of dip rock slopes. Due to the characteristic "no pre-existing weak planes" of anti-dip rock slopes, the cumulative deformation and fracture of rock strata result in slope destabilisation. Focusing on the evolution chain "deformation of rock strata - damage (or fracture) of rock strata - slope destabilisation", this study investigates the mechanisms of deformation and destabilisation of anti-dip rock slopes through a numerical simulation method. For the anti-dip rock slope with a large dip angle of the rock strata, the significant stress characteristic of the rock strata "tension near the upper surface - compression near the lower surface" results in obvious flexural deformation and tensile fracture. The slope undergoes long-term damage and eventually occurs destabilisation. This stress characteristic gradually diminishes and eventually vanishes with decreasing dip angle of the rock strata. The resulting initiation mode of slope destabilisation transitions from tensile fracture to compressive fracture of the rock strata at the slope toe. Meanwhile, the destabilisation mode of slopes transitions from toppling type to sliding type, and the corresponding failure boundary transitions from dual stage toppling-fracture type to multistage sliding type. Moreover, the combined effects of the slope angle and the dip angle of the rock strata are discussed during the process of deformation and destabilisation of anti-dip rock slopes.
The impact of environmental protection tax on green M&amp;As
Authors: Wang Wei , Shi Tingting , Jiang Zhixin 
Published: November 2023

Abstract
This article aims to investigate the impact of The Environmental Protection Tax Law of the People’s Republic of China implemented in 2018 on the decision-making process of green M&As, and incorporates heavy-polluting companies listed on the A-share market in Shanghai and Shenzhen in its study. After collecting data on the green M&As among these firms, the study empirically examines the impact of the environmental protection tax on their decision-making. The findings indicate that: (1)The environmental protection tax offers favorable conditions for enterprises to engage in green M&As.(2)From the perspective of heterogeneity, The environmental protection tax has a particularly evident incentive effect in green M&As of enterprises incorporated in regions with high tax standards, state-owned enterprises, and more heavily-polluting enterprises in central and western China.(3)Green M&As contribute to increased green innovation output by enterprises.(4)The moderating role of regional marketization and corporate legitimacy awareness in the impact of environmental protection taxes on green M&As. Based on these empirical results, several policy recommendations are proposed, including the effective utilization of the environmental protection tax system and the promotion of green transformation among enterprises through price mechanism.
Deep-brain stimulation of the human nucleus accumbens-medial septum enhances memory formation
Authors: Strange Bryan , Treu Svenja , Barcia Juan , Diaz Cristina Torres , Rosa Javier Gonzalez , Nombela Cristina , Pineda Jose , Torres Daniel , Kunz Lukas , Hellerstedt Robin , Avecillas-Chasin Josue , Lara Monica , Navas Marta , Galarza Ana , Garcia Julia , Oliviero Antonio , Seijo Fernando , Horn Andreas , Li Ningfei , Axmacher Nikolai , Canals Santiago , Reneses Blanca , Bierbrauer Anne 
Published: November 2023

Abstract
Deep-brain stimulation (DBS) is a potential novel treatment for memory dysfunction. Current attempts to enhance memory focus on stimulating human hippocampus or entorhinal cortex. However, an alternative strategy is to stimulate brain areas providing modulatory inputs to medial temporal memory-related structures, such as the nucleus accumbens (NAc), which is implicated in enhancing episodic memory encoding. Here, we show that NAc-DBS improves episodic and spatial memory in psychiatric patients. During stimulation, NAc-DBS increased the probability that infrequent (oddball) pictures would be subsequently recollected, relative to periods off stimulation. In a second experiment, NAc-DBS improved performance in a virtual path-integration task. An optimal electrode localization analysis revealed a locus spanning postero-medio-dorsal NAc and medial septum predictive of memory improvement across both tasks. Patient structural connectivity analyses, as well as NAc-DBS-evoked hemodynamic responses in a rat model, converge on a central role for NAc in a hippocampal-mesolimbic circuit regulating encoding into long-term memory. Thus, short-lived, phasic NAc electrical stimulation dynamically improved memory, establishing a critical on-line role for human NAc in episodic memory and providing an empirical basis for considering NAc-DBS in patients with loss of memory function.
Management of Acute Myocardial Infarction in a Liver Transplant Recipient- A rare case report
Authors: Makwana Harsha , Chaudhary Aditi , Dhongani Harshit , Kapadia Parth , Bhut Sumit , Modi Kushal , Chandak Megha 
Published: November 2023

Abstract
Liver transplantation (LT) improves outcomes and quality of life in patients with end-stage liver disease (ESLD). As a result of improved accessibility and recipient survival, transplant candidates are becoming increasingly older, have more co-morbidities, and experience more long-term complications, all of which created new challenges in post-transplantation care. In post-transplant period, a multitude of factors can influence cardiovascular risk in transplant recipients due to aggravation in recipient populations from new-onset dyslipidemia, hypertension, glucose intolerance, and nephrotoxicity as side effects of immunosuppressive agents. Traditional cardiovascular risk factors are becoming increasingly prevalent in the aging population of Liver Transplant candidates, and coronary artery disease is considered to be more common than previously thought. Cardiovascular events are recognized as prominent causes of early and late mortality in liver transplant recipients The most common cardiovascular diseases in transplant candidates are ischemic coronary artery disease (CAD) and cardiomyopathy. We describe a complex case of liver transplant recipient in a 50-year-old male patient with no known history of coronary artery disease who developed progressive acute myocardial infarction within 6 months of liver transplant, ultimately thrombolysed to optimize myocardial perfusion. Management of myocardial ischemia was complicated by high risk of bleeding in the setting of coagulopathy. Once thrombolysed and hemodynamic stability was achieved, the patient immediately shifted for coronary angiography and staged coronary angioplasty was done for triple vessel coronary disease in patient at cardiac institute.
Overcoming the tumor biological barrier: a multistage drug delivery strategy for DDR1-mediated resistant colorectal cancer therapy
Authors: Yan Jun , Cui Guangman , Deng Shaohui , Zhang Biao , Lin Zhousheng , Lan Xinyue , Li Zelong , Yu Meng , Yao Guangyu 
Published: November 2023

Abstract
Chemotherapy resistance remains a significant challenge in the treatment of colorectal cancer (CRC). The roles of discoidin domain receptor 1 (DDR1) in mediating tumor-collagen interactions and promoting cancer progression have been extensively studied. However, the specific mechanisms of DDR1 contribute to matrix-mediated drug resistance (MMDR) remain poorly understood. In this study, we elucidated a novel mechanism in which the interactions between tumor cells and collagen lead to promotion of drug efflux and collagen fiber alignment as well as suppression of immune infiltration, resulting in MMDR in CRC. To address this issue, we employed a multistage drug delivery system carrying Ddr1-siRNA and chemotherapeutic agents to disrupt collagen deposition and alignment by silencing DDR1 in ECM, enhancing chemotherapy drugs diffusion and facilitating immune infiltration. These findings not only revealed a novel role for collagen-rich matrix mediated by DDR1 in tumor resistance, but also introduced a promising CRC treatment strategy.
Validation of the Center for Neurologic Study Bulbar Function Scale–Chinese Version in a Population with Amyotrophic Lateral Sclerosis
Authors: Ye Shan , Chen Lu , Murphy Davan , Wu Jieying , Zhang Hui , Liu Hong , Zou Boliang , Hou Guanghao , Zhang Nan , Yin Tielun , Smith Richard A , Fan Dongsheng 
Published: November 2023

Abstract

Objective
The Center for Neurologic Study Bulbar Function Scale (CNS-BFS) was specifically designed as a self-report measure of bulbar function. The purpose of this research was to validate the Chinese translation of the CNS-BFSC as an effective measurement for the Chinese ALS population.
Methods
A total of 111 ALS patients were included in this study. The CNS-BFSC, the three bulbar function items from the ALSFRS-R, and visual analog scales (VASs) for speech, swallowing and salivation were assessed in the study. Forty-six ALS patients were retested with the same scales 5–10 days after the first evaluation.
Results
CNS-BFSC sialorrhea, speech and swallowing subscores were separately correlated with VAS subscores (p < 0.001). The CNS-BFSC total, sialorrhea and speech scores were significantly correlated with the ALSFRS-R bulbar subscore (p < 0.001). The CNS-BFSC total score and ALSFRS-R bulbar subscale were highly predictive of clinician diagnosis of impaired bulbar function (area under the receiver operating characteristic curve, 0.947 and 0.911, respectively; p < 0.001). A cutoff value for the CNS-BFSC total score was selected by maximizing Youden's index; this cutoff score was 33, with 86.4% sensitivity and 93.3% specificity. The CNS-BFSC total score and the sialorrhea, speech and swallowing subscores had good–retest reliability (p > 0.05). The Cronbach’s α of the CNS-BFSC was 0.972.
Conclusion
The Chinese version of the CNS-BFSC has acceptable efficiency and reliability for the assessment of bulbar dysfunction in ALS patients.
Altered gut microbiota in hereditary transthyretin amyloidosis with polyneuropathy
Authors: Chen Chieh-Chang , Tseng Ping-Huei , Hsueh Hsueh-Wen , Chiang Ming-Chang , Tzeng Shiou-Ru , Chiang Tsung Hsien , Wu Ming-Shiang , Hsieh Sung-Tsang , Chao Chi-Chao 
Published: November 2023

Abstract
Increasing evidence suggests that gut microbiota alterations are related to development and phenotypes of many neuropsychiatric diseases. Here, we evaluated the fecal microbiota and its clinical correlates in patients with hereditary transthyretin amyloidosis (ATTRv) and polyneuropathy. Fecal microbiota from 38 ATTRv patients and 39 age-matched controls was analyzed by sequencing 16S V3-V4 ribosomal RNA, and its relationships with clinical characteristics of polyneuropathy and cardiomyopathy were explored. The familial amyloidotic polyneuropathy (FAP) stage was stage I, II, and III in 13, 18, and 7 patients respectively. 99mTc-PYP SPECT showed a visual score of 2 in 15 and 3 in 21 patients. The gut microbiota of ATTRv patients showed higher alpha diversity (p = 0.002 for Chao1 index) and dissimilar beta diversity (p = 0.001) compared to controls. Relative abundance of microbiota was dominated by Firmicutes and decreased in Bacteroidetes in ATTRv patients than in controls. Patients with more myocardial amyloid deposition were associated with increased alpha diversity, and the abundance of Clostridia was significantly correlated with pathophysiology of polyneuropathy in ATTRv patients. These findings demonstrated alterations in the gut microbiota, especially Firmicutes, in ATTRv. The association between altered microbiota and phenotypes of cardiomyopathy and polyneuropathy might suggest potential contributions of gut microbiota to ATTRv pathogenesis.
Internet of Things in Medical Education: A Systematic Mapping Review
Authors: Behmanesh Ali , Davarzani Mohammad Hoseeinzadeh , Shams Roshanak , Soleimanpour Samira 
Published: November 2023

Abstract

Context The Internet of Things (IoT) has emerged as a promising technology with the potential to transform medical professional training and education. IoT refers to a network of physical items that are embedded with sensors, software, and connections that exchange data via the Internet. IoT provides the possibility of merging electronic health records, medical devices, and wearable technologies to create an interactive learning environment in medical education. Objectives The current study's goal was to identify and map current IoT advancements in medicine by conducting a systematic mapping review of the existing research on IoT in medical education. It intends to provide answers to major research question, such as trends and activities in IoT development in medical education. Methods Following PRISMA-ScR guidelines, a systematic mapping review was conducted in major online scientific databases such as Web of Science, Scopus, PubMed, and IEEE Xplore up to end of 2022 to identify empirical studies related to IoT and medical education. A total of 199 papers were found, from which 24 were ultimately selected based on particular inclusion/exclusion criteria. Results While the majority of medical IoT research are conducted across a network of twelve different countries, the United States has emerged as the leader in developing IoT systems for medical education. The dynamic potential of IoT devices and sensors in medical education included areas such as activity monitoring, physiological monitoring, data collecting, and simulation. In medical education, IoT applications include surgical training, non-surgical teaching, and resident monitoring. Conclusions The study findings highlight the importance of further research efforts aimed at addressing challenges and unlocking the full array of benefits IoT has to offer in medical education. It is expected that these discoveries will catalyze interest among medical education leaders and policymakers, encouraging them to explore the promising horizons of wearable technology and IoT applications in medical education, ultimately leading to enhanced educational outcomes and practices.
Synergizing Machine Learning and Cybersecurity for Robust Digital Protection.
Authors: Shukla Sameer 
Published: November 2023

Abstract
In today's dynamic digital landscape, cyber threats are growing in sophistication and frequency, challenging traditional cybersecurity methods. This research paper, titled "Fortifying Digital Defenses: Exploring the Synergy of Machine Learning and Cybersecurity," delves into the pivotal role of machine learning in bolstering our cyber defenses. Machine learning, a subset of artificial intelligence, has emerged as a powerful tool in the fight against cyber adversaries. The paper explores how machine learning techniques can significantly enhance threat detection, incident response, and security system adaptability. It showcases real-world applications, such as anomaly detection, behavioral analysis, and predictive threat intelligence, illustrating the symbiotic relationship between machine learning and cybersecurity. By embracing machine learning, organizations can stay ahead of emerging threats, adapt more effectively, and fortify their digital defenses in this ever-evolving digital age.