bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups
Authors: Gritti Paolo , Bonfanti Marco , Zangari Rosalia , Bonanomi Ezio , Farina Alessia , Pezzetti Giulio , Pelliccioli Isabella , Longhi Luca , Di Matteo Maria , Viscone Andrea , Lando Gabriele , Cavalleri Gaia , Gerevini Simonetta , Biroli Francesco , Lorini Ferdinando Luca 
Published: January 2024

Abstract
Background
The ultra-low-frequency pressure reactivity index (UL-PRx) has been established as a surrogate method for bedside estimation of cerebral autoregulation (CA). Although this index has been shown to be a predictor of outcome in adult and pediatric patients with traumatic brain injury (TBI), a comprehensive evaluation of low sampling rate data collection (0.0033 Hz averaged over 5 min) on cerebrovascular reactivity has never been performed.

Objective
To evaluate the performance and predictive power of the UL-PRx for 12-month outcome measures, alongside all International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) models and in different age groups. To investigate the potential for optimal cerebral perfusion pressure (CPPopt).

Methods
Demographic data, IMPACT variables, in-hospital mortality, and Glasgow Outcome Scale Extended (GOSE) at 12 months were extracted. Filtering and processing of the time series and creation of the indices (cerebral intracranial pressure (ICP), cerebral perfusion pressure (CPP), UL-PRx, and deltaCPPopt (ΔCPPopt and CPPopt-CPP)) were performed using an in-house algorithm. Physiological parameters were assessed as follows: mean index value, % time above threshold, and mean hourly dose above threshold.

Results
A total of 263 TBI patients were included: pediatric (17.5% aged ≤ 16 y) and adult (60.5% aged > 16 and < 70 y and 22.0% ≥ 70 y, respectively) patients. In-hospital and 12-month mortality were 25.9% and 32.7%, respectively, and 60.0% of patients had an unfavorable outcome at 12 months (GOSE). On univariate analysis, ICP, CPP, UL-PRx, and ΔCPPopt were associated with 12-month outcomes. The cutoff of ~ 20–22 for mean ICP and of ~ 0.30 for mean UL-PRx were confirmed in all age groups, except in patients older than 70 years. Mean UL-PRx remained significantly associated with 12-month outcomes even after adjustment for IMPACT models. This association was confirmed in all age groups. UL-PRx resulted associate with CPPopt.

Conclusions
The study highlights UL-PRx as a tool for assessing CA and valuable outcome predictor for TBI patients. The results emphasize the potential clinical utility of the UL-PRx and its adaptability across different age groups, even after adjustment for IMPACT models. Furthermore, the correlation between UL-PRx and CPPopt suggests the potential for more targeted treatment strategies.
Trial registration: ClinicalTrials.gov identifier: NCT05043545, principal investigator Paolo Gritti, date of registration 2021.08.21.
Microalgae biofuels: illuminating the path to a sustainable future amidst challenges and opportunities
Authors: Wang Min , Ye Xiaoxue , Bi Hongwen , Shen Zhongbao 
Published: January 2024

AbstractThe development of microalgal biofuels is of significant importance in advancing the energy transition, alleviating food pressure, preserving the natural environment, and addressing climate change. Numerous countries and regions across the globe have conducted extensive research and strategic planning on microalgal bioenergy, investing significant funds and manpower into this field. However, the microalgae biofuel industry has faced a downturn due to the constraints of high costs. In the past decade, with the development of new strains, technologies, and equipment, the feasibility of large-scale production of microalgae biofuel should be re-evaluated. Here, we have gathered research results from the past decade regarding microalgae biofuel production, providing insights into the opportunities and challenges faced by this industry from the perspectives of microalgae selection, modification, and cultivation. In this review, we suggest that highly adaptable microalgae are the preferred choice for large-scale biofuel production, especially strains that can utilize high concentrations of inorganic carbon sources and possess stress resistance. The use of omics technologies and genetic editing has greatly enhanced lipid accumulation in microalgae. However, the associated risks have constrained the feasibility of large-scale outdoor cultivation. Therefore, the relatively controllable cultivation method of photobioreactors (PBRs) has made it the mainstream approach for microalgae biofuel production. Moreover, adjusting the performance and parameters of PBRs can also enhance lipid accumulation in microalgae. In the future, given the relentless escalation in demand for sustainable energy sources, microalgae biofuels should be deemed a pivotal constituent of national energy planning, particularly in the case of China. The advancement of synthetic biology helps reduce the risks associated with genetically modified (GM) microalgae and enhances the economic viability of their biofuel production.
Graphical Abstract
Distinct changes to pancreatic volume rather than pancreatic autoantibody positivity: insights into immune checkpoint inhibitors induced diabetes mellitus
Authors: Wei Hung-Hui , Lai Ying-Chieh , Lin Gigin , Lin Cheng-Wei , Chang Ya-Chu , Chang John Wen-Cheng , Liou Miaw-Jene , Chen I-Wen 
Published: January 2024

Abstract
Background
Immune checkpoint inhibitors (ICI) are promising treatment options for various cancers. However, their use is associated with immune-related adverse events (irAEs), including ICI-induced diabetes mellitus (ICI-DM). This study aimed to investigate the clinical features of ICI-DM, with a particular focus on alterations to pancreatic volume.

Methods
We conducted a retrospective review of 2829 patients who received ICI treatment at the Chang Gung Memorial Hospital, Linkou, between January 2014 and December 2021. New-onset diabetes or diabetic ketoacidosis (DKA) was identified in ten patients receiving ICI therapy. Pancreatic volumes were assessed by manual segmentation of computed tomography (CT) images before and after ICI-DM diagnosis.

Results
Among these ten patients, nivolumab was the most commonly used ICI (50.0%), followed by pembrolizumab (30.0%) and atezolizumab (20.0%). One patient received combination therapy with nivolumab and ipilimumab. The median age was 63.01 years (range: 40.1 − 87.8). ICI-DM developed after a median of 13.5 cycles (range: 2 − 42) of ICI treatment or 9.85 months (range:1.5 − 21.3) since ICI initiation. The initial presentation was DKA in 60.0% of patients. All patients had low or undetectable C-peptide levels (range: <0.033 − 0.133 nmol/L) and were negative for most type 1 diabetes mellitus (T1DM)-related autoantibodies; only one patient tested positive for glutamic acid decarboxylase antibodies. CT imaging revealed significant pancreatic atrophy, with a median pancreatic volume decrease of 19.92% (P = 0.038) from baseline and sustained significant decline at last follow-up (median − 37.14%, P = 0.012).

Conclusions
ICI-DM is often accompanied by pancreatic atrophy and approximately two-thirds of patients initially present with DKA. Although the majority of ICI-DM patients lack T1DM-related autoantibodies, identifying diminished pancreatic volumes through CT imaging provides valuable clues into the subclinical aspects of ICI-DM development, aiding in the prevention of diabetic emergencies.

Trial registration
Not applicable.
Sphingobium sp. V4, a bacterium degrading multiple allelochemical phenolic acids
Authors: Zhang Chunyang , Liu Shuping , Guo Qingying , Li Demin , Li Zelin , Ma Qinyuan , Liu Hong , Zhao Qian , Liu Hongliang , Ding Zhongfeng , Gong Weihua , Gao Yuhao 
Published: January 2024

Abstract
Background
Continuous cropping challenges constrain the development of agriculture. Three main obstacles limit continuous cropping: autotoxicity of plant allelochemicals, deterioration of physicochemical characteristics of soil, and microflora imbalance. Plant-derived phenolic acids can cause autotoxicity, which is considered the main factor mediating continuous cropping obstacles. Reducing the phenolic acids in continuous cropping soils can decrease the autotoxicity of phenolic acids and ameliorate continuous cropping obstacles. Therefore, it is important to study the microbial resources that degrade allelochemical phenolic acids. Thus, the bacterial strain V4 that can degrade phenolic acids was isolated, identified, and genomically analyzed.

Results
Strain V4 isolated from strawberry soil using vanillic acid-mineral agar was identified as a Gram-negative short rod bacterium. Subsequent 16S rRNA phylogenetic analysis revealed that V4 clustered with members of the genus Sphingobium. The most closely related species were Sphingobium lactosutens DS20T (99% similarity) and Sphingobium abikonense NBRC 16140T (97.5% similarity). V4 also shared > 95% sequence similarity with other members of Sphingobium, so Sphingobium sp. V4 was named accordingly. Biochemical tests revealed that the biochemical characteristics of Sphingobium sp. V4 were similar to its most similar strains except for some properties. Sphingobium sp. V4 effectively degraded vanillic acid, ferulic acid, p-coumaric acid, p-hydroxybenzoic acid, and syringic acid. V4 grew best at the conditions of 30 °C, pH 6.0–7.0, and 0–0.05% NaCl. 500 mg/L vanillic acid was completely degraded by V4 within 24 h under the optimal conditions. Whole genome analysis showed that Sphingobium sp. V4 contained one chromosome and three plasmids. Two genes involved in vanillic acid degradation were found in the V4 genome: the gene encoding vanillate O-demethylase oxidoreductase VanB on the chromosome and the gene encoding vanillate monooxygenase on a large plasmid. The organization of vanillate catabolic genes differed from the adjacent organization of the genes, encoding vanillate o-demethylase VanA and VanB subunits, in Pseudomonas and Acinetobacter.

Conclusions
The isolated bacterium Sphingobium sp. V4 degraded multiple phenolic acids. Its properties and genome were further analyzed. The study provides support for further investigation and application of this phenolic acid-degrading microorganism to alleviate continuous cropping obstacles in agriculture.
MATEO: intermolecular α-amidoalkylation theoretical enantioselectivity optimization. Online tool for selection and design of chiral catalysts and products
Authors: Carracedo-Reboredo Paula , Aranzamendi Eider , He Shan , Arrasate Sonia , Munteanu Cristian R. , Fernandez-Lozano Carlos , Sotomayor Nuria , Lete Esther , González-Díaz Humberto 
Published: January 2024

AbstractThe enantioselective Brønsted acid-catalyzed α-amidoalkylation reaction is a useful procedure is for the production of new drugs and natural products. In this context, Chiral Phosphoric Acid (CPA) catalysts are versatile catalysts for this type of reactions. The selection and design of new CPA catalysts for different enantioselective reactions has a dual interest because new CPA catalysts (tools) and chiral drugs or materials (products) can be obtained. However, this process is difficult and time consuming if approached from an experimental trial and error perspective. In this work, an Heuristic Perturbation-Theory and Machine Learning (HPTML) algorithm was used to seek a predictive model for CPA catalysts performance in terms of enantioselectivity in α-amidoalkylation reactions with R2 = 0.96 overall for training and validation series. It involved a Monte Carlo sampling of > 100,000 pairs of query and reference reactions. In addition, the computational and experimental investigation of a new set of intermolecular α-amidoalkylation reactions using BINOL-derived N-triflylphosphoramides as CPA catalysts is reported as a case of study. The model was implemented in a web server called MATEO: InterMolecular Amidoalkylation Theoretical Enantioselectivity Optimization, available online at: https://cptmltool.rnasa-imedir.com/CPTMLTools-Web/mateo. This new user-friendly online computational tool would enable sustainable optimization of reaction conditions that could lead to the design of new CPA catalysts along with new organic synthesis products.
New type of the unique continuation property for a fractional diffusion equation and an inverse source problem
Authors: Liu Wenyi , Du Chengbin , Li Zhiyuan 
Published: January 2024

AbstractIn this work, a new type of the unique continuation property for time-fractional diffusion equations is studied. The proof is mainly based on the Laplace transform and the properties of Bessel functions. As an application, the uniqueness of the inverse problem in the simultaneous determination of spatially dependent source terms and fractional order from sparse boundary observation data is established.
Performance comparison of three prototype biomass stoves with traditional and Mirt stoves for baking Injera
Authors: Tesfay Asfafaw Haileselassie , Tsegay Kibreab , Kahsay Mulu Bayray , Hailu Mesele Hayelom , Adaramola Muyiwa Samuel 
Published: January 2024

Abstract
Background
Injera is food consumed daily by Ethiopians like bread and rice in other parts of the world. Biomass stoves are used to bake Injera in most rural households. The unsustainable use of fuelwood causes deforestation. Improved cook stoves such as Mirt (name in local language) were introduced to replace traditional stoves and save fuel wood. This study presents a performance comparison of three newly developed prototype biomass stoves with traditional and Mirt stoves. The prototype stoves were made with a clay pan (designated MUC: Mekelle University prototype with clay pan), with a glass pan (MUG) and with an aluminum pan (MUA). Controlled cooking tests were conducted for each type of stove to determine the thermal efficiency and specific fuel consumption.

Results
The thermal efficiencies of the traditional, Mirt, MUC, MUA and MUG stoves were found to be 14%, 17%, 21%, 29% and 32%, respectively. Similarly, the percentage fuel wood savings by Mirt, MUC, MUA and MUG compared to the traditional stove were 32%, 48%, 64% and 67%, respectively. The results indicate that the prototype stoves had significantly better performance compared to the traditional and Mirt stoves.

Conclusion
The prototype stoves have the potential to reduce fuel wood consumption by more than half of that currently consumed employing traditional stoves. In addition to the economic benefit of saving fuel wood, the improved stoves will have significant environmental implication. Based on the fuel saving figures, it is estimated that 0.4, 0.5 and 0.52 tons/year of fuel wood may be saved per household adopting MUC, MUA and MUG stoves, respectively.
SGLT2 inhibitors and the cardiac rhythm: unraveling the connections
Authors: Paul Aritra , Tabaja Chadi , Wazni Oussama 
Published: January 2024

AbstractSodium-glucose co-transporter 2 inhibitors (SGLT2is), primarily used for managing type 2 diabetes mellitus, have recently gained attention for their potential cardiovascular benefits. This review explores the emerging evidence surrounding the association between SGLT2is and arrhythmias. Initial studies and large cardiovascular outcome trials have indicated that SGLT2is may reduce major adverse cardiovascular events, including HFHs, which inherently suggests a potential anti-arrhythmic role. Mechanistic insights propose that SGLT2is may exert their anti-arrhythmic effects by modulating cardiac ion channels, thereby impacting cardiac action potentials. Direct clinical evidence linking SGLT2 is to reduced arrhythmias remains limited but evolving. Potential implications of these findings could revolutionize treatment approaches, expanding the indications for SGLT2is prescriptions beyond the diabetic population and possibly providing a novel therapeutic avenue for patients at risk of arrhythmias. However, the exact mechanism, efficacy, and safety profile need further investigation. While various post-hoc and meta-analyses shed light on the topic, prospective, randomized controlled trials are warranted to explicate the potential of SGLT2is in arrhythmia management, their place in clinical guidelines, and their overall impact on patient outcomes.
Osteogenesis imperfecta type XVII: expansion of the phenotype
Authors: Dunleavy Brooke M. , Schildt Alison J. , Harrington Caitlin , Stevenson David A. 
Published: January 2024

Abstract
Background
Biallelic variants in SPARC are extremely rare, and have been reported in only a few cases of autosomal recessive osteogenesis imperfecta (OI) type XVII. Here, we describe an individual with a SPARC homozygous missense variant (c.787G > A; p.Glu263Lys) and expand on the phenotype.

Case presentation
The proband had a history of multiple fractures, osteopenia, severe thoracolumbar levoscoliosis, rib fusion, global hypotonia, conductive hearing loss, and was non-ambulatory. Several of his features were similar to previously described cases, such as early neuromuscular concerns, scoliosis, long bone and vertebral compression fractures, and delayed motor milestones, suggesting these are consistent across SPARC-related osteogenesis imperfecta (OI). However, the proband sustained fractures at a younger age with a more severe course compared to most previous reports. He also had bony fusion of several ribs and hearing loss, which have not been reported in SPARC-related OI.

Conclusions
Overall, the proband supports the current phenotype of SPARC-related OI, but also expands the phenotypic variability.
Feeling better? – Identification, interventions, and remission among women with early postpartum depressive symptoms in Sweden: a nested cohort study
Authors: Gidén Karin , Vinnerljung Lisa , Iliadis Stavros I. , Fransson Emma , Skalkidou Alkistis 
Published: January 2024

Abstract

Background
Postpartum depression affects around 12% of mothers in developed countries, with consequences for the whole family. Many women with depressive symptoms remain undetected and untreated. The aim of this study was to investigate to what extent women with depressive symptoms at 6 weeks postpartum are identified by the healthcare system, the interventions they received, and remission rates at 6 months postpartum.

Methods
Postpartum women scoring 12–30 on the Edinburgh Postnatal Depression Scale (EPDS) at 6 weeks after delivery (n = 697) were identified from the longitudinal cohort study “Biology, Affect, Stress, Imaging and Cognition” (BASIC) in Uppsala, Sweden. A total of 593 women were included. Background and remission information at 6 months was collected from the BASIC dataset. Medical records were examined to identify interventions received.

Results
Most women (n = 349, 58.7%) were not identified by the healthcare system as having depressive symptoms and 89% lacked any record of interventions. Remission rates at 6 months postpartum were 69% in this group. Among women identified by the healthcare system, 90% received interventions and about 50% were in remission at 6 months postpartum. The EPDS reduction during the study period was largest in the group identified by the child health services (CHS, −5.15) compared to the non-identified (−4.24, p < 0.001).

Conclusions
Despite screening guidelines, many women with depressive symptoms had no documentation of screening or interventions by the healthcare system. Furthermore, a significant proportion did not achieve remission despite interventions. Being identified by CHS was associated with the largest reduction of symptoms. Research is needed to understand gaps in the healthcare processes, to better identify peripartum depression.
Cost-Effectiveness of Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation for Older Patients With High-Risk Myelodysplastic Syndrome: Analysis of BMT CTN 1102
Authors: Saber Wael , Bansal Aasthaa , Li Lily , Scott Bart L. , Sangaralingham Lindsey R. , Thao Viengneesee , Roth Joshua A. , Wright Winona , Steuten Lotte M.G. , Pidala Joseph A. , Mishra Asmita , Maziarz Richard T , Westervelt Peter , McGuirk Joseph P. , Cutler Corey , Nakamura Ryotaro , Ramsey Scott D. 
Published: January 2024

PURPOSE BMT CTN 1102 was a phase III trial comparing reduced-intensity allogeneic hematopoietic cell transplantation (RIC alloHCT) to standard of care for persons with intermediate- or high-risk myelodysplastic syndrome (MDS). We report results of a cost-effectiveness analysis conducted alongside the clinical trial. METHODS Three hundred eighty-four patients received HCT (n = 260) or standard of care (n = 124) according to availability of a human leukocyte antigen–matched donor. Cost-effectiveness was calculated from US commercial and Medicare perspectives over a 20-year time horizon. Health care utilization and costs were estimated using propensity score–matched cohorts of HCT recipients in the OptumLabs Data Warehouse (age 50-64 years) and Medicare (age 65 years and older). EuroQol 5 Dimension (EQ-5D) surveys of trial participants were used to derive health state utilities. RESULTS Extrapolated 20-year overall survival for those age 50-64 years was 29% for HCT (n = 105) versus 13% for usual care (n = 44) and 31% for HCT (n = 155) versus 12% for non-HCT (n = 80) for those age 65 years and older. HCT was more effective (+2.36 quality-adjusted life-years [QALYs] for age 50-64 years and +2.92 QALYs for age 65 years and older) and more costly (+$452,242 in US dollars (USD) for age 50-64 years and +$233,214 USD for age 65 years and older) than usual care, with incremental cost-effectiveness ratios of $191,487 (USD)/QALY and $79,834 (USD)/QALY, respectively. For persons age 50-64 years, there was a 29% chance that HCT was cost-effective using a willingness-to-pay (WTP) threshold of $150K (USD)/QALY and 51% at a $200K (USD)/QALY. For persons age 65 years and older, the probability was 100% at a WTP >$150K (USD)/QALY. CONCLUSION Among patients age 65 years and older with high-risk MDS, RIC HCT is a high-value strategy. For those age 50-64 years, HCT is a lower-value strategy but has similar cost-effectiveness to other therapies commonly used in oncology.
Preference Externality Estimators: A Comparison of Border Approaches and IVs
Authors: Li Xing , Hartmann Wesley R. , Amano Tomomichi 
Published: January 2024

This paper compares two estimators—the Border Approach and an Instrumental Variable (IV) estimator—using a unified framework where identifying variation arises from “preference externalities,” following the intuition in Waldfogel (2003) . We highlight two dimensions in favor of the IV approach. First, an econometric model of the data-generating process reveals that the border approach requires a set of identification assumptions that are not easily satisfied in practice: the ignorance of some payoff-relevant information and conflicting spatial correlation assumptions. The IV approach, in contrast, exhibits greater internal validity because it is derived from the model that generates the data. Second, the border approach suffers from representative issues when the true effect sizes are different between border and off-border regions. We use a common political advertising example to evaluate these estimators and suggest ways to evaluate or limit the above concerns, such as excluding localities that are a large share of the policy making region and evaluating spatial correlations of observables. We find the border approach’s representative issue to be substantial when the ignorance assumption is most plausible and observe that spatial correlations do not reflect those needed in the unobservables for consistency of the estimator. The IV, in contrast, does not exhibit concerns related to local average treatment effects. We also derive the specific conditions when the border approach can reduce bias relative to OLS. This paper was accepted by Raphael Thomadsen, marketing. Funding: This work was supported by National Natural Science Foundation of China (NSFC) [72072004, 72131001]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4977 .