bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Effects of Citronellol Against Rhabdomyolysis-Induced Acute Kidney Injury in Mice by Inhibiting NF-κB and IL-1β
Authors: Nasrawi Yasmeen , Hashim Kadhim Sermad 
Published: December 2023

Objectives: acute kidney injury (AKI) is a serious pathophysiology side effect of rhabdomyolysis. Inflammatory mechanisms play a role in the development of rhabdomyolysis-induced AKI. Citronellol (CT) is a naturally occurring monoterpene alcohol (3,7-Dimethyl-6-often-1-ol) found in aromatic plant species' essential oils. In this study, we explored the protective effects of Citronellol on glycerol-induced AKI.
Methods: Four groups of eight mice each (n=8) were formed by randomly dividing the animals into the groups, glycerol-induced AKI model group, low-dose CT-treated group (50mg/kg), high-dose CT-treated group (100mg/kg), and control group. The renal functions of mice from all groups were evaluated using serum urea and creatinine. Creatine kinase (CK) level was used to detect rhabdomyolysis. Inflammatory response was determined using Nf-kB and iL-1B levels.
Results: Citronellol in both doses 50&100 mg/kg significantly decreased serum urea, creatinine and CK as Compared to the glycerol group, as well as treatment with citronellol resulted in a lower expression of both NF-κB and IL-1β in the renal tissue, indicating that citronellol may have an anti-inflammatory effect in AKI.
Conclusion: prophylaxis with low and high doses of citronellol improved inflammatory responses and renal function. It's possible that by inhibiting Nf-kB and iL-1B, these positive effects were achieved, inhibiting the development of inflammatory cytokines as a result. These discoveries reveal fresh details regarding a potential treatment option for kidney injury caused by rhabdomyolysis.
Machine learning–based detection of sarcopenic obesity and association with adverse outcomes in patients undergoing surgical treatment for spinal metastases
Authors: Khalid Syed I. , Massaad Elie , Kiapour Ali , Bridge Christopher P. , Rigney Grant , Burrows Akeive , Shim Jane , De la Garza Ramos Rafael , Tobert Daniel G. , Schoenfeld Andrew J. , Williamson Theresa , Shankar Ganesh M. , Shin John H. 
Published: December 2023

OBJECTIVE
The distributions and proportions of lean and fat tissues may help better assess the prognosis and outcomes of patients with spinal metastases. Specifically, in obese patients, sarcopenia may be easily overlooked as a poor prognostic indicator. The role of this body phenotype, sarcopenic obesity (SO), has not been adequately studied among patients undergoing surgical treatment for spinal metastases. To this end, here the authors investigated the role of SO as a potential prognostic factor in patients undergoing surgical treatment for spinal metastases.

METHODS
The authors identified patients who underwent surgical treatment for spinal metastases between 2010 and 2020. A validated deep learning approach evaluated sarcopenia and adiposity on routine preoperative CT images. Based on composition analyses, patients were classified with SO or nonsarcopenic obesity. After nearest-neighbor propensity matching that accounted for confounders, the authors compared the rates and odds of postoperative complications, length of stay, 30-day readmission, and all-cause mortality at 90 days and 1 year between the SO and nonsarcopenic obesity groups.

RESULTS
A total of 62 patients with obesity underwent surgical treatment for spinal metastases during the study period. Of these, 37 patients had nonsarcopenic obesity and 25 had SO. After propensity matching, 50 records were evaluated that were equally composed of patients with nonsarcopenic obesity and SO (25 patients each). Patients with SO were noted to have increased odds of nonhome discharge (OR 6.0, 95% CI 1.69–21.26), 30-day readmission (OR 3.27, 95% CI 1.01–10.62), and 90-day (OR 4.85, 95% CI 1.29–18.26) and 1-year (OR 3.78, 95% CI 1.17–12.19) mortality, as well as increased time to mortality after surgery (12.60 ± 19.84 months vs 37.16 ± 35.19 months, p = 0.002; standardized mean difference 0.86). No significant differences were noted in terms of length of stay or postoperative complications when comparing the two groups (p > 0.05).

CONCLUSIONS
The SO phenotype was associated with increased odds of nonhome discharge, readmission, and postoperative mortality. This study suggests that SO may be an important prognostic factor to consider when developing care plans for patients with spinal metastases.
Health benefits of aqueous and ethanolic extracts of medinilla speciosa blume
Authors: Purba Florensa Rosani , Rahayu Ika , Sudradjat Susana Elya , Timotius Kris Herawan 
Published: December 2023

Medinilla speciosa (local name: parijoto) has many pharmacological benefits, including for treating female infertility. This study aimed to identify bioactive compounds of the aqueous and ethanolic extracts of Medinilla speciosa; to find information on their pharmacological benefits, and to do its docking profile with the protein phosphatase1, which is associated with the enhancement of female fertility. Articles were searched from PubMed. The components of Medinilla speciosa were analyzed with LC-MS/MS. In silico study was conducted based PubChem, Protein Data Base, and Swiss ADME. Pyrx 0.8 and Discovery Studio Visualizer v21.1 were used to predict the interaction. Four flavonoids were identified, namely fisetin, robinetin, luteolin, and kaempferol. Except for robinetin, they exist in glycosidic form. One polyphenol, ellagic acid, was also identified. Literature studies showed they have various pharmacological benefits, such as antioxidants, anti-inflammation, anticancer, antidiabetes, organ protection, and antimicrobial. However, no information is available on its potential for fertility enhancement. Docking analysis showed that the bioactive compounds interact with the A and C chains of the catalytic domain of protein phosphatase 1 (PP1). Aqueous and ethanolic extracts of Medinilla speciosa possess fisetin, robinetin, luteolin, kaempferol, and ellagic acid that bind to catalytic chains of protein phosphatase 1.
IMPLEMENTASI PUTUSAN HAKIM DALAM PENETAPAN DISPENSASI PERKAWINAN ANAK USIA DINI
Authors: Renaldy Khrisna Nurdiyanto  , Yudhi Widyo Armono  , Sumarwoto  
Published: December 2023

Penelitian ini bertujuan untuk mengetahui Implemntasi putusan Hakim Pengadilan Agama Boyolali dalam menyelesaikan perkara dispensasi perkawinan Nomor 321/Pdt.P/2020/PA.Bi. dan untuk mengetahui faktor yang mendasari ditolaknya permohonan dispensasi perkawinan. Metode yang digunakan dalam penelitian ini adalah metode pendekatan normatif yang bersifat deskriptif karena penelitian menggunakan ketetapan undang-undang tentang perkawinan UU No. 1 Tahun 1974 sebagaimana UU No.16 Tahun 2019 tentang Perkawinan Pengumpulan data menggunakan dengan cara menhgumpulkann dan menghimpun dari bahan hukum primer, sekunder dan tersier yang berkaitan dengan dispensasi perkawinan. Analisis data dalam penelitian ini dilakukan dengan menggunakan metode analisis data berupa kualitatif. Metode ini dilakukan dengan cara mempelajari buku-buku kepustakaan, literatur yang berkaitan dengan dispensasi perkawinan. Hasil penelitian ini adalah Implemntasi putusan Hakim Pengadilan Agama Boyolali dalam memutus perkara dispensasi perkawinan Nomor 321/Pdt.P/2020/PA.Bi mengacu pasal 7 ayat (1) UU No. 1 tahun 1974 sebagaimana Undang-Undang No.16 Tahun 2019 tentang Perkawinan. Implemntasi putusan hakim yang digunakan Pengadilan Agama Boyolali dalam memutus perkara Nomor 321/Pdt.P/2020/PA.Bi ialah salah satunya pasal 49 ayat (1); (2) UU No. 7 tahun 1989 mengalami perubahan UU No. 23 tahun 2006. Implemntasi putusan hakim yang mendasari dikabulkanya permohonan dispensasi perkawinan dengan Nomor 321/Pdt.P/2020/PA.Bi karena terjadinya penolakan KUA terlebih dahulu terhadap dispensasi pernikahan dibawah umur yang hendak melakukan perkawinan.Hal ini dapat dilihat dalam pasal 7 UU No. 1 tahun 1974 sebagaimana Undang-Undang No.16 Tahun 2019 tentang Perkawinan dan pasal 15 ayat (2) KHI. akan tetapi memberikan dispensasi atau kelonggran atas permohonan kepada pemohon. Dalam dikabulkanya permohonan dispensasi perkawinan Majelis Hakim melihat fisik dan mental dari anak pemohon layak atau tidaknya melangsungkan pernikahan. Karena sangat penting untuk mengetahui alasan-alasan yang sah untuk memberi izin tentang dispensasi perkawinan.
Pengenalan Manajemen Administrasi Pada Unit Kegiatan Mahasiswa (Ukm) Fakultas Kehutanan Universitas Mulawarman
Authors: Warsudi  , Deni La , Supriyanto Edi , Sanjaya Sagita , Abadi Abadi , Ngali Darmawati 
Published: December 2023

ABSTRAK
Managemen administrasi merupakan seni dalam mengatur sumber daya manusia dan sumber daya lainnya untuk mencapai tujuan tertentu, hal yang penting dan utama dalam suatu organisasi karena managemen administrasi dapat menunjang tercapainya tujuan yang diharapkan. Dalam suatu organisasi sangat dibutuhkan personal yang dapat melakukan kegiatan keadministrasian dengan baik agar proses berjalannya organisasi dapat berjalan dengan baik, tentunya hal ini dapat terlaksana apabila sistem ke managemen administrasinya sudah berjalan dengan baik.

Kata kunci: Managemen, Administrasi, Organisasi
Pengembangan Vertikultur Solusi Budidaya Tanaman Vertikal Di Lahan Sempit (Upaya Pemberdayaan Ibu-Ibu Rumah Tangga Di Kelurahan Gunung Kelua-Samarinda)
Authors: Manurung Hetty , Kusuma Ratna , Samsurianto Samsurianto , Lariman Lariman , Susanto Dwi 
Published: December 2023

ABSTRAK
Wilayah Kelurahan Gunung Kelua Samarinda merupakan wilayah dengan pertumbuhan jumlah penduduk yang semakin meningkat setiap tahunnya. Kebutuhan lahan pemukiman semakin meningkat pula dan mengakibatkan terjadinya alih fungsi lahan dari lahan pertanian menjadi lahan pemukiman guna memenuhi kebutuhan primer yaitu papan (rumah). Kebutuhan akan pangan otomatis semakin meningkat pula, dan minim nya ketersediaan lahan terbuka menjadi pemikiran dalam mengupayakan pemanfaatan area sempit menjadi lahan tanam untuk bercocok tanam, melalui salah satu cara yang dapat diterapkan yaitu Vertikultur. Pelatihan Vertikultur Tanaman ini bertujuan membekali peserta dengan pengetahuan dasar yang sederhana dan mudah dipahami melalui bagaimana memperbanyak tanaman dengan memanfaatkan lahan yang tersisa dari halaman rumah tempat tinggal. Dalam upaya meningkatkan keterampilan, ibu ibu di lingkungan kelurahan Gunung Kelua samarinda diberikan materi, dengan berbagai praktek di lapangan mengenai teknik vertikultur tanaman. Program pengabdian masyarakat ini berlangsung dengan baik dan efektif, meliputi teori dan praktik lapangan dengan persentase 25% teori dan 75% praktik. Kegiatan diikuti oleh 30 orang ibu ibu yang tergabung dalan kegiatan PKK dan kampong KB Suwandi Mandiri. Hasil pelatihan tersebut peserta dapat mempraktekkan dan mengaplikasikan teknik vertikultur pada budidaya bahan pangan sehari hari di sekitar tempat tinggal masing-masing.
Historical and legal overview of the State and Advocacy interaction within the system of human rights and freedoms protection
Authors: Bandurka S. S. 
Published: December 2023

The article examines the interaction between the State and the Advocacy as a human rights protection organisation from the historical and legal perspective. At all times of its formation and development, the Advocacy has operated within a certain system of state and social relations and was called upon to promote the protection of human interests in accordance with the laws of the State in which it operated. The activities of the Advocacy have always been multifaceted, and therefore the article describes various methods of studying the interaction between the State and the Advocacy from the historical and legal perspective. The necessity of studying the interaction between the State and the Advocacy to refer to the legal documents of the past which regulated the activities of the Advocacy and its relationship with the State is emphasised.
It is demonstrated that at all times the institution of human rights protection, which is now perceived as the Advocacy, has not acted in isolation, but has been a component of the society system, acting in accordance with the laws and in accordance with the procedure established by the State. The Advocacy functions in the unified legal system of the state together with the state authorities, central executive bodies and their local bodies and institutions, local self-government bodies, and civil society institutions. Therefore, when analysing the interaction between the state and the Advocacy, characterising the activities of the Advocacy in the protection of human rights and freedoms, it is necessary to consider the activities of the subjects of power in the protection of human rights and freedoms. Interaction between the State and the Advocacy is a social interaction.
It is emphasized that in the process of social interaction, social, statutory, socio-legal actions of partners take place, and mutual adaptation of actions of each of them, which leads to the use of various research methods in the process of historical and legal review of interaction between the State and the Advocacy.
Limits of competence of a forensic commodity expert in determining the characteristics of goods in cases of customs rules violation
Authors: Diachuk S. О. 
Published: December 2023

Today, all goods, regardless of the country of origin, are subject to classification, that is, codes are determined for goods in accordance with the classification groupings specified in the UCC of the Economic and Monetary Union. Expertise on determining the conformity of the characteristics of goods according to the UCC FEA, regardless of the purpose of establishing the code, is only a means of establishing the circumstances of implementation, that is, the characteristics on which the definition of the goods code is based, but by its task it cannot support the adoption of a decision on the determination interpretation of the product code according to the UCC FEA. Understanding the correctness of drawing up an expert's opinion allows to avoid difficulties when conducting a forensic commodity examination.
The classification of goods is carried out in accordance with the requirements of the UCC FEA and is a technique that allows to present the classified goods in the form of a group of signs (product code) established by this classifier. When conducting a forensic commodity expert examination, a commodity expert may not exceed his or her powers and go beyond his or her competence when answering questions about determining the characteristics of the object of research according to the code of the UCC FEA. In the course of a commodity examination, a commodity expert determines only the characteristics of the goods, and the UCC FEA code is not determined.
The article clarifies the peculiarities of determining the UCC FEA code, explains from a practical point of view what is the work of a forensic expert in conducting this type of forensic commodity examination. The article provides recommendations for forensic institutions on how to resolve the issues raised by forensic commodity expertise and the correctness of drawing up an expert's opinion, since this allows avoiding difficulties in conducting forensic commodity expertise.
The prospect of using nisin for pre-milking treatment of the udder of cows
Authors: Trukhanovych T. , Kukhtyn M. , Perkiy Yu. , Boltyk N. , Klymyk V. , Rushchynska T. , Tykhonova B. 
Published: December 2023

Bacteriocins, in particular, nisin, are increasingly used for the development of sanitizing agents along with natural antimicrobial substances, such as organic acids, essential oils, alcohols, and others. The purpose of the work was to investigate the bactericidal effect of nisin on test cultures of microorganisms that cause mastitis in cows for its use in means for pre-milking treatment of the udder in combination with lactic acid. The minimum inhibitory concentration was studied on test cultures of Staphylococcus aureus (ATCC 25923), Escherichia coli (055К59 №3912/41) and Streptococcus uberis (field strain) by the method of serial dilutions with exposures of 30 seconds and 10 minutes. In the experiment was used nisin produced by Glory Chem Co., Ltd. (China), lactic acid food 80 % solution (“Klebrig”, Belgium). It was established that the minimum inhibitory concentration of nisin after exposure for 30 seconds on S. aureus cultures was 1.0 % and Str. uberis – 0.125 %. Nisin at the content of 2 % and 1 % in the solution did not show the minimum inhibitory concentration on E. coli cultures within 30 seconds, but inhibited 91.7 and 82.3 % of the microflora, respectively, at this concentration. It was found that the minimum inhibitory concentration of lactic acid after exposure for 30 seconds on S. aureus and E. coli cultures was 2 %, and on Str. uberis – 1 %. At the same time, lactic acid diluted below the minimum inhibitory concentration, in particular, 1 % and 0.5 %, inhibited 98.9–96.5 % of microorganisms in the solution, which may be sufficient for its use in means for processing the udder of cows before milking and at lower concentration. The study of the bactericidal effect by the well method showed that nisin exhibits a synergistic bactericidal effect with lactic acid and can be used in combination to create a means for pre-milking treatment of the udder of cows. Therefore, in order to create means for pre-milking treatment of the skin of udders of cows, it is necessary that the working concentration of nisin be from 0.5 to 1.0 %, and lactic acid from 1 to 2 %.
Peningkatan Nilai Tambah Limbah Hasil Pertanian Sebagai Pakan Ternak Bernutrisi Tinggi Berbasis Mesin Pencacah di Desa Bunder
Authors: Meidayanti Karina , Siska Astri Iga , Kareja Novilia 
Published: December 2023

Luasan area persawahan yang dimiliki oleh Kecamatan Kabat, diimbangi oleh besarnya potensi akan limbah pertaniannya. Kecamatan Kabat, melalui BPP telah mencanangkan program pertanian sehat dan program tersebut adalah terkait pakan sehat telah disosialisasikan kepada kelompok tani binaan. Permasalahan yang paling yang dihadapi mitra: limbah hasil pertanian pada mitra belum dimanfaatkan sama sekali sehingga mencemari lingkungan; kelompok tani belum memiliki keilmuan dan keahlian dalam pakan fermentasi, mengoperasikan mesin dan merawat mesin pencacah limbah hasil pertanian; mitra belum memiliki fasilitas berupa mesin pencacah limbah hasil pertanian; SDM belum mampu melakukan analisis usaha dan pencatatan keuntungan secara sistematis. Solusi tepat guna yang ditawarkan pada mitra dikerjakan dalam tiga tahapan yaitu; 1) melakukan sosialisasi pembuatan pakan ternak pada mitra, 2) pelatihan pembuatan pakan menggunakan mesin pencacah dan melakukan SOP perawatan mesin, 3) Pelatihan manajerial dan analisis usaha produk. Hasil yang diperoleh dari kegiatan ini yakni pakan ternak fermentasi yang siap dikomersialisasikan dan diaplikasikan untuk ternak.
Potensi Kurkumin Sebagai Bahan Anti Fertilitas
Authors: Purwaningsih, MS, PA Endang 
Published: December 2023

Kunyit (Curcuma longa, Linn) merupakan salah satu herbal yang sering digunakan sebagai bumbu, pengawet maupun pewarna makanan. Senyawa utama ekstrak kunyit adalah kurkumin.yang memberikan warna kuning yang khas. Telah banyak dilakukan penelitian yang berkaitan dengan efek biologik dan aksi farmakologiknya, seperti antiinflamasi, antikanker, antioksidan dan antifertilitas.Dalam makalah ini akan dipaparkan mengenai efek kurkumin terhadap sistem reproduksi, khususnya sebagai antiferlitas. Pada sistem reproduksi pria/jantan kurkumin menghambat kualitas spema seperti motilitas, viabilitas sperma, kapasitasi, reaksi akrosom, dan meningkatkan morfologi sperma abnormal. Kurkumin juga dapat melindungi dampak negatif alkohol, potasium dikromat, kadmium, metronidazol terhadap testis, kualitas sperma dan produksi hormon testosteron. Pada sistem reproduksi wanita/betina kurkumin dapat menghambat ovulasi, implantasi, dan produksi hormon FSH, LH, estrogen maupun progesteron. Selain itu kurkumin dapat memblok siklus estrus dan menimbulkan perubahan biokimiawi pada cairan uterus. Dapat disimpulkan bahwa kurkumin memiliki potensi dalam pengendalian kesuburan khususnya sebagai bahan antifertilitas baik pria maupunwanita. Efek antifertilitas kurkumin bersifat reversibel.
Terahertz focusing blazed diffractive optical elements for frequency demultiplexing
Authors: Kaluza Mateusz , Komorowski Paweł , Zagrajek Przemysław , Siemion Agnieszka 
Published: December 2023

This study presents the novel optical passive components for spatial frequency division demultiplexing of terahertz (THz) radiation. Four different diffractive optical elements (DOEs) were designed as the combination of phase kinoform lenses and phase blazed diffraction gratings. The designed structures were verified in numerical simulations and they showed the promising results. Subsequently, they were manufactured using fused deposition modeling (FDM) 3D printing technology from highly transparent cyclic olefin copolymer (COC). The manufactured structures were examined in the experimental setup. The results matched numerical simulations. Thus, eight frequencies in the range from 150 GHz to 220 GHz every 10 GHz were spatially separated. The novel design solution guaranteed 63% higher relative efficiency compared to the reference DOE. The presented study can be suitable as the application for 6G technology telecommunication systems as the spatial frequency division demultiplexing component for the THz radiation band.
Traits of weed species present in maize respond to tillage and cropping systems
Authors: Bensch Johanna , Pannwitt Heike , Gerowitt Bärbel 
Published: December 2023

IntroductionArable weeds adapt to any changes in disturbance and management. On arable fields, tilling disturbs the soil, while cropping practices like rotation, pesticide use, fertilizer use, and the use of subsidiary crops characterize the management of the field. On a species level, weeds adapt in their abundance and composition. The species have certain traits to use the on-site resources best. Our objective was to investigate if traits beyond just species describe the adaptation of weeds to tillage and cropping systems. Therefore, we present a use case of weeds on fields cropped with maize in Germany.Material and methodsOver 2 years, we conducted a nationwide weed survey on 577 maize fields. On each field, the abundance of each weed species was counted on 10 randomly sampled square plots of 0.1 m² not treated with herbicides at the fourth to eighth leaf stages of the maize. Weed species frequent on at least 5% of the fields were assigned traits. Traits were taken from published updated databases. We interviewed all farmers about the management practices of their fields.ResultsThe management practice data identified three management clusters of tillage and cropping sequence on maize fields. The standard system so far is a management system characterized by inversion tillage and maize cropped in rotations (“Traditional”). The two transformation systems are maize cropped in rotations but with non-inversion tillage as the method of soil disturbance (“Conservational”) and maize cropped continuously regardless of the tillage system (“Monoculture”). Ordination techniques showed that both weed species and traits are assigned to these management systems. Traditional disfavored weed species with a greater plant height. Conservational selected dicot weed species with a high seed weight and a long flowering duration. Monoculture mainly filtered monocot weed species and favored weeds that germinate in spring.DiscussionOur study describes weed responses on transformations of maize cropping in tillage and cropping systems on both the species and the trait level. This application expresses the importance and value of collecting weed surveys with field management data on a geographically widespread and repeated timescale.