bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dopamine Modulates Effective Connectivity in Frontal Cortex
Authors: Vogelsang David A. , Furman Daniella J. , Nee Derek E. , Pappas Ioannis , White Robert L. , Kayser Andrew S. , D'Esposito Mark 
Published: October 2023

Abstract
There is increasing evidence that the left lateral frontal cortex is hierarchically organized such that higher-order regions have an asymmetric top–down influence over lower order regions. However, questions remain about the underlying neuroarchitecture of this hierarchical control organization. Within the frontal cortex, dopamine plays an important role in cognitive control functions, and we hypothesized that dopamine may preferentially influence top–down connections within the lateral frontal hierarchy. Using a randomized, double-blind, within-subject design, we analyzed resting-state fMRI data of 66 healthy young participants who were scanned once each after administration of bromocriptine (a dopamine agonist with preferential affinity for D2 receptor), tolcapone (an inhibitor of catechol-O-methyltransferase), and placebo, to determine whether dopaminergic stimulation modulated effective functional connectivity between hierarchically organized frontal regions in the left hemisphere. We found that dopaminergic drugs modulated connections from the caudal middle frontal gyrus and the inferior frontal sulcus to both rostral and caudal frontal areas. In dorsal frontal regions, effectivity connectivity strength was increased, whereas in ventral frontal regions, effective connectivity strength was decreased. These findings suggest that connections within frontal cortex are differentially modulated by dopamine, which may bias the influence that frontal regions exert over each other.
Mutagenic, Anti-mutagenic, and Cytotoxic Activities of Methanol, Hexane, and Ethyl Acetate Extracts of Zingiber zerumbet (L.) Smith
Authors: Hariri Farah Syahibah Mohd , Hamid Asmah , Rajab Nor Fadilah 
Published: October 2023

Background Zingiber zerumbet (L.) Smith (lempoyang) has a traditional application in the treatment of indigestion, worm infestation, loss of appetite, and postpartum conditions. Objectives Extracts of Z. zerumbet (methanol, hexane, and ethyl acetate) were utilized to investigate the mutagenic, anti-mutagenic, and cytotoxic properties. Materials and Methods Initially, a mutagenicity test (Ames test) was conducted, followed by an anti-mutagenicity test, to assess the potential of Z. zerumbet extracts in inhibiting mutagenicity induced by sodium azide and 9-aminoacridine. Furthermore, the cytotoxic ability of the extracts was evaluated using the methyl thiazolyl tetrazolium (MTT) assay. Results The mutagenicity assessment revealed that the methanol extract of Z. zerumbet exhibited a twofold increase in the number of revertants in Salmonella typhimurium strain TA 1537. Similar results were observed for the hexane extract, except at a concentration of 6.25 mg/mL, where no significant increase in revertants was observed. On the other hand, the ethyl acetate extract demonstrated a twofold increase in revertants in S. typhimurium strain TA 1535. Notably, the ethyl acetate extract displayed remarkable anti-mutagenic activity against 9-aminoacridine, while the hexane extract exhibited strong anti-mutagenic activity against sodium azide. Regarding cytotoxicity assessment using the MTT assay, the methanol extract of Z. zerumbet exhibited the highest cytotoxicity with an IC50 value estimated at 388.50 ± 135.75 µg/mL. The hexane and ethyl acetate extracts showed IC50 values of 514.17 ± 135.75 and 589.67 ± 241.67 µg/mL, respectively. Conclusion The extracts displayed both mutagenic and cytotoxic activities. However, they also exhibited promising anti-mutagenic potential, which could be harnessed for cancer prevention purposes.
Cultural Beliefs on Cleft lip and/or Cleft Palate and Their Implications on Management: A Systematic Review
Authors: Hasanuddin H. , Al-Jamaei Aisha AH. , Van Cann Ellen M. , Ruslin Muhammad , Helder Marco N. , Deshpande Prasannasrinivas , Forouzanfar Tymour 
Published: October 2023

Objective This article examines and summarizes the published epidemiological literature on cross-cultural variations. Particular emphasis was put on addressing cross-cultural beliefs on the causes, management, and attitude toward cleft lip and/or cleft palate. A healthcare provider's awareness of these cross-cultural attitudes and beliefs is vital for promoting effective collaboration with patients’ families and ensuring a favorable medical outcome. Design Systematic review. Setting Not applicable. Participants Patients with cleft lip and/or cleft palate, their families, their communities, and healthcare providers. Interventions Not applicable. Main Outcome Measures Not applicable. Results All relevant and eligible studies were identified using PubMed and Google Scholar databases. The cultural belief was categorized and measured using Murdock's Theories of Illness. The study was reported in compliance with PRISMA guidelines. The quality of the selected studies was evaluated in accordance with the Critical Appraisal Skills Programme criteria (CASP). Fourteen articles covering thirteen countries on four continents met the inclusion criteria. In diverse communities, cleft lip and/or cleft palate was attributed to natural (infection, medication, improper diet, smoke, or radiation) or supernatural (God, eclipse, ancestral spirit, and curse) causes. Reported consequences include stigmatization, inappropriate treatments, leaving patients untreated, and infanticide. Conclusion Cultural beliefs are the main cause of misconceptions surrounding a cleft lip and/or cleft palate. There is also a need for public health care providers’ intervention to educate society about the natural causes and ease of management, thereby increasing opportunities for patients substantially.
Prospective Multicenter Study of Salto Talaris Ankle Arthroplasty With Minimum 4-Year Follow-Up
Authors: Mathews Chelsea S. , Davitt James , Coetzee J. Chris , Shofer Jane , Norvell Daniel C. , Ledoux William R. , Sangeorzan Bruce J. 
Published: October 2023

Background: Total ankle arthroplasty (TAA) continues to be investigated as a primary treatment for end-stage ankle arthritis. The objective of this study is to report mid- to long-term results of the Salto Talaris TAA using prospectively collected patient-reported outcomes and implant survival rates with 4- to 13-year follow-up. Methods: This was a retrospective study of prospectively collected data from 2 multicenter cohort studies from 3 centers. Three hundred fourteen subjects who received a Salto Talaris TAA from 2005 to 2015 were included in the study. Follow-up ranged 4-13 years following index procedure. Outcomes included 36-Item Short Form Health Survey (SF-36) mental and physical component summary scores, pain scores, and adverse events including additional surgeries, revision, or removal of components. Results: Significant improvements were seen in pain and physical function scores at 2-year follow-up and were generally maintained through most recent follow-up. The survival rate of the prosthesis was >95% (n = 30/32 at >10 years, n = 272/282 at 4.5-10 years). Thirteen patients (4.1%) underwent revision or removal of their prosthesis. Time to revision ranged from 2 months to 6.5 years following the index procedure. Twenty-two patients (7.0%) had additional surgery that did not involve revision or removal of components. Conclusion: Treatment of end-stage ankle arthritis with this implant provided patients with improved pain and functional outcome scores at mid- to long-term follow-up. The significant improvements reported at 2-4 years appeared to endure through the extended follow-up period. Level of Evidence: Level III, retrospective cohort study.
Normal Values for Distal Tibiofibular Syndesmotic Space With and Without Subject-Driven External Rotation Stress
Authors: Shamrock Alan , Den Hartog Taylor J. , Dowley Kieran , Day Jonathan , Barbachan Mansur Nacime Salomao , Carvalho Kepler Alencar Mendes de , de Cesar Netto Cesar , O’Malley Martin 
Published: October 2023

Background: The diagnosis and treatment of distal tibiofibular syndesmosis (DTFS) injury can be challenging, especially in cases of subtle instability that may be masked on 2-dimensional conventional radiographs. Weightbearing computed tomography (WBCT) has recently emerged as a useful diagnostic tool allowing direct assessment of distal tibiofibular area widening. The purpose of the current study was to examine and report normal threshold values for DTFS area measurements in a cohort of healthy volunteers, assessing the ankles in natural weightbearing position and under subject-driven external rotation stress. Methods: In this prospective study, we enrolled 25 healthy volunteers without a history of DTFS injury or high ankle sprain, previous foot and ankle surgery, or current ankle pain. Subjects with any prior ankle injuries were excluded. Study participants underwent bilateral standing nonstress and external rotation stress WBCT scans. The DTFS area (mm2) was semiautomatically quantified on axial-plane WBCT images 1 cm proximal to the apex of the talar dome using validated software. Syndesmosis area values were compared between “unstressed” and “stressed” ankles, as well as left and right ankles. Statistical analysis was performed using independent t tests/Wilcoxon analysis with statistical significance defined as P <.05. Results: The study cohort consisted of 50 ankles in 25 patients (12 males, 48%) with a mean age of 28.7 ± 9.3 years. In the unstressed ankle, the mean pooled DTFS area was determined to be 103.8 + 20.8 mm2. The mean syndesmosis area of unstressed left ankles (104.2 + 19.5 mm2) was similar to unstressed right ankles (109.2 + 17.2 mm2) in the cohort ( P = .117). With external rotation stress, the DTFS area of left ankles (mean difference −0.304 mm2, CI −12.1 to 11.5; P = .082), right ankles (mean difference −5.5 mm2, CI 16.7-5.7; P = .132), and all ankles (mean difference −2.9 mm2, CI −10.8 to 5.1; P = .324) remained similar. Conclusion: This study presents normal values and range for DTFS area calculation. In uninjured ankles with expected intact ligaments, subject-driven external rotation stress did not result in significant widening of the DTFS space as imaged on with WBCT. Level of Evidence: Level II, cross-sectional study.
Study on the friction-induced vibration and wire corrugation of metro rigid overhead wire-pantograph systems
Authors: Mei Guiming , Li Xianhang , Zhang Weihua 
Published: October 2023

Most recently, metro rigid overhead wire-pantograph systems are subjected to severe wear of overhead wires and current collectors throughout China, which are difficult to completely solve up to now. The severe wear of metro rigid overhead wire-pantograph systems is probably brought about by the medium-high frequency vibration of the metro rigid overhead wire-pantograph systems. Coincidentally, corrugation is frequently found in rigid overhead wire systems, but rarely in flexible catenary systems. A frictional self-excited vibration model of a rigid overhead wire-pantograph system was set up. The self-excited vibration characteristics were investigated using the transient analysis and the motion stability analysis. Results show that when the friction coefficient is greater than 0.07, the rigid overhead wire-pantograph system is more prone to self-excited vibration. The self-excited vibration frequencies cover a range of 20–1000 Hz. The simulated overhead wire corrugation approaches the measured corrugation in wavelength. The influence factor analysis displays that the friction coefficient, zigzag layout of rigid catenary wires, and sliding direction of pantographs have significant effects on overhead wire corrugation, and but the train speed, normal force, main spring stiffness, and span of two positioning clips have a little effect.
Trends in ages at death of Norwegian centenarians: the 1870–1904 birth cohorts
Authors: Medford Anthony , Skirbekk Vegard , Strand Bjørn Heine 
Published: October 2023

Background: With rapidly rising life expectancy and ageing populations, interest has grown in the survival patterns and ages at death at the highest ages. In Scandinavia, the accumulation of very old population segments coupled with long-established, high-quality population registers permit meaningful analysis. Methods: This study is based on individual level data from extinct Norwegian birth cohorts using data obtained from the Norwegian Civil Register System. We assess trends in the ages at death of centenarians in Norway for cohorts born between 1870 and 1904 for evidence of any secular increase using quantile regression. Results: We observed that there is no upward trend in centenarian lifespans, in line with recent observations in Sweden, but contrary to the upward trend at the very highest percentiles as observed in Denmark. Conclusions: The available evidence suggests that the stagnation in centenarian lifespans may be partly due to the failure to find ways of dealing with neurodegenerative diseases.
Clinical outcomes related to portal pressures before and after embolization of large portosystemic shunts in cirrhosis
Authors: Rajesh Sasidharan , Philips Cyriac Abby , Ahamed Rizwan , Singh Shobhit , Abduljaleel Jinsha K , Tharakan Ajit , Augustine Philip 
Published: October 2023

Objectives: Embolization of large portosystemic shunts effectively controls gastric variceal bleeding and prevents hepatic encephalopathy. The significance of dynamic changes in hepatic venous pressure gradient before and after embolization on clinical events and patient outcomes remains unknown. Methods: In this retrospective single-center series, 46 patients with gastric variceal bleeding, hepatic encephalopathy, or both undergoing embolization (January 2018 to October 2020) were included, and dynamic changes in portal pressures were analyzed against patient outcomes. Results: Males predominated. The most common portosystemic shunt syndrome was the lienorenal shunt. In all, 34 patients underwent embolization for hepatic encephalopathy and 11 for gastric variceal bleeding. The proportion of patients surviving at the end of 12 and 32 months was 86.96 and 54.35%, respectively. The hepatic venous pressure gradient before shunt embolization was 13.4 ± 3.2 and 16.9 ± 3.7 mm Hg after occlusion ( p < 0.001). Bleeding from varices on overall follow-up was notable in five patients (10.9%), and overt hepatic encephalopathy in four ( N = 42, 9.5%) patients at 6–12 months. The development of infections within 100 days and beyond the first year was associated with the risk of dying at the end of 12 and 32 months, respectively. Elevation of hepatic venous pressure gradient by >4 mm Hg from baseline and an absolute increase to >16 mm Hg immediately post-procedure significantly predicted the development of early- and late-onset ascites, respectively. Conclusion: Close monitoring for the development of infections and optimization of beta-blockers and diuretics after shunt embolization may improve clinical outcomes and help identify patients who will benefit from liver transplantation pending prospective validation.
Primary or Delayed Repair for Complete Atrioventricular Septal Defect, Tetralogy of Fallot, and Ventricular Septal Defect: Relationship to Country Economic Status
Authors: Bateson Brian P. , Deng Luqin , Ange Brittany , Austin Erle , Dabal Robert , Bowser Taylor , Pennington John , Sivakumar Sivalingam , Lee Cheul , Truong Nguyen Ly Thinh , Jacobs Jeffery , Cervantes Jorge , Jagannath B.R. , Jonas Richard A. , Kirklin James K. , St.Louis James 
Published: October 2023

Objective Primary repair in the first six months of life is routine for tetralogy of Fallot, complete atrioventricular septal defect, and ventricular septal defect in high-income countries. The objective of this analysis was to understand the utilization and outcomes of palliative and reparative procedures in high versus middle-income countries. Methods The World Database of Pediatric and Congenital Heart Surgery identified patients who underwent surgery for: tetralogy of Fallot, complete atrioventricular septal defect, and ventricular septal defect. Patients were categorized as undergoing primary repair, repair after prior palliation, or palliation only. Country economic status was categorized as lower middle, upper middle, and high, defined by the World Bank. Multiple logistic regression models were utilized to identify independent predictors of hospital mortality. Results Economic categories included high (n = 571, 5.3%), upper middle (n = 5,342, 50%), and lower middle (n = 4,793, 49.7%). The proportion of patients and median age with primary repair were: tetralogy of Fallot, 88.6%, 17.7 months; complete atrioventricular septal defect, 83.4%, 7.7 months; and ventricular septal defect, 97.1%, ten months. Age at repair was younger in high income countries ( P < .0001). Overall mortality after repair was lowest in high income countries. Risk factors for hospital mortality included prematurity, genetic syndromes, and urgent or emergent operations (all P < .05). Conclusions Primary repair was selected in >90% of patients, but definitive repair was delayed in lower and upper middle income countries compared with high-income countries. Repair after prior palliation versus primary repair was not a risk factor for hospital mortality. Initial palliation continues to have a small but important role in the management of these three specific congenital heart defects.
Genetic correlation for alcohol consumption between Europeans and East Asians
Authors: Liu Xuan , Li Yongang 
Published: October 2023

AbstractGenome-wide association studies (GWAS) have identified many genetic variants associated with alcohol consumption in Europeans and East Asians, as well as other populations. However, the genetic homogeneity and heterogeneity between these populations have not been thoroughly investigated, despite evidence of varying effect sizes of variants between ethnicities and the presence of population-specific strong signals of selection on loci associated with alcohol consumption. In order to better understand the relationship between Europeans and East Asians in the genetic architecture of alcohol consumption, we compared their heritability and evaluated their genetic correlation using GWAS results from UK Biobank (UKB) and Biobank Japan (BBJ). We found that these two populations have low genetic correlation due to the large difference on chromosome 12. After excluding this chromosome, the genetic correlation was moderately high ($${r}_{g}$$ = 0.544, p = 1.12e-4) and 44.31% of the genome-wide causal variants were inferred to be shared between Europeans and East Asians. Given those observations, we conducted a meta-analysis on UKB and BBJ and identified new signals, including the CADM2 gene on chromosome 3, which has been associated with various behavioral and metabolic traits. Overall, our findings suggest that the genetic architecture of alcohol consumption is largely shared between Europeans and East Asians, but there are exceptions such as the enrichment of heritability on chromosome 12 in East Asians.
Changes in fish resources 5 years after implementation of the 10-year fishing ban in the Chishui River, the first river with a complete fishing ban in the Yangtze River Basin
Authors: Liu Fei , Wang Zixin , Xia Zhijun , Wang Jianwei , Liu Huanzhang 
Published: October 2023

Abstract
Background
To rehabilitate the depleted fish resources of the Yangtze River Basin, China, a 10-year fishing ban has been implemented. This national initiative has attracted worldwide attention. The present study aimed to explore the ecological process and recovery effectiveness of this complete fishing ban in the Chishui River, the first river where the fishing ban was enacted in the Yangtze River Basin. Changes in fish resources were analyzed based on investigations conducted 5 years before (2012–2016) and 5 years after (2017–2021) the implementation of the fishing ban in four reaches along the longitudinal gradient.

Results
A total of 140 fish species, including 127 native and 13 exotic species, were collected during the study period. The number of fish species as well as the diversity indices showed no significant temporal changes. However, 11 native species that had disappeared for many years appeared again after the fishing ban. The occurrence rates of some key protected species, Procypris rabaudi, Acipenser dabryanus, Euchiloglanis davidi and Myxocyprinus asiaticus, increased after the fishing ban, while Coreius guichenoti, Percocypris pingi, Onychostoma angustistomata and Leptobotia rubrilabris showed no obvious recovery. The fish assemblage structure in nearly all reaches (except the headwater) showed significant temporal changes with an increase in the relative abundance of larger body-sized species. The population structure of most dominant species improved greatly with the mean standard length and the mean body weight as well as the proportion of larger-sized individuals clearly increasing. In addition, the density of fishes changed dramatically with the catch per unit effort (CPUE) increasing by 140–210% for different study reaches.

Conclusions
The present study confirmed that the complete fishing closure is an effective measure to facilitate fish resources recovery. These results provide valuable references for evaluating the effectiveness of the 10-year fishing ban policy in the entire Yangtze River.
Safety and feasibility of sutureless pars-plana vitrectomy in sub-Tenon anesthesia (SAFE-VISA): a prospective study
Authors: Lohmann Tibor , Baumgarten Sabine , Prinz Julia , Walter Peter , Koutsonas Antonis 
Published: October 2023

Abstract
Background
To determine the safety and feasibility of sutureless pars-plana vitrectomy (ppV) in sub-Tenon anesthesia.

Methods
In this prospective study. Pain and anxiety at various times after ppV using a visual analogue scale (VAS) and Wong-Baker-FACES scale as well as visual sensations during surgery were investigated. The surgeon evaluated motility, chemosis, overall feasibility.

Results
ppV was performed on 67 eyes (33 sub-Tenon anesthesia, 34 general anesthesia). Pain during surgery in sub-Tenon anesthesia was 1.8 ± 2.2 (0.0–8.0), anxiety was 2.3 ± 2.2 (0.0–8.5). There was a moderate correlation between pain and anxiety (R2 = 0.58). Comparing sub-Tenon and general anesthesia no difference in pain perception was found the day after surgery. 27.3% of patients saw details, 21.2% saw colors, 90.1% saw light/motion perception, 3.0% had no light perception. Median chemosis after surgery was 1.0 (IQR = 1.0). Median motility of the eye during surgery was 1.0 (IQR = 1.0), median grade was 1.0 (IQR = 1.0). 24.2% of patients showed subconjunctival hemorrhage during or after surgery.

Conclusions
Sutureless pars-plana vitrectomy in sub-Tenon anesthesia was performed safely, with pain and anxiety levels tolerable for the patients and without the necessity for presence of an anesthesiologist. With 88.9% of patients willing to undergo vitreoretinal surgery in sub-Tenon anesthesia again, we recommend it as a standard option.
Trial registration This study was approved by the Institutional Ethical Review Board of the RWTH Aachen University (EK 111/19). This study is listed on clinicaltrials.gov (ClinicalTrials.gov identifier: NCT04257188, February 5th 2020).