bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dose characterization study evaluating the pharmacodynamics and safety of a concentrated alfaxalone solution (4%) as an intramuscular sedative in dogs
Authors: Hoon Ting Michelle Angel Yvonne , Kat Irving Tjiah Wern , Pasloske Kirby , Farry Trisha , Goodwin Wendy Anne 
Published: December 2023

AbstractAlfaxalone is a commonly employed veterinary anaesthetic induction and sedation agent. A 4% w/v preserved, aqueous formulation of alfaxalone ‘RD0387’ (A4%) has recently been developed. To evaluate the sedative effects of A4%, three doses, 5 mg kg−1 (A5); 7.5 mg kg−1 (A7.5) and 10 mg kg−1 (A10) were administered intramuscularly into the epaxial musculature of six healthy adult mixed‐breed dogs in an experimental, randomized, blinded, crossover study. Sedation time variables, quality of sedation (including onset of sedation and recovery), physiological variables, response to cephalic vein catheterization and frequency of undesirable events were recorded. Continuous variables were analysed between treatments (one‐way ANOVA or restricted maximum likelihood modelling) and within treatments compared with baseline (Tukey's test). Categorical data were analysed between treatments (Kruskal‐Wallis' test) and within treatments from baseline (Dunn's test). Significance was set at p < .05. All dogs became sedated (laterally recumbent) and sedation onset was significantly faster in groups A7.5 (9.8 ± 5.3 min) and A10 (9.1 ± 5.6 min) compared to A5 (25.6 ± 16.1 min) (p = .033, p = .027, respectively). Duration of sedation was significantly longer in A10 (168.5 ± 70.6 min) and A7.5 (143.8 ± 58 min) compared to A5 (63.8 ± 28.2 min) (p = .005 and p = .003, respectively). Dogs in A10 had a superior quality of onset of sedation compared to A5 (p = .028). Sedation scores and quality of recovery from sedation were not significantly different between doses. Two dogs (2/6) in A5 were insufficiently sedated for cephalic catheterization. Ataxia was the most frequently observed undesirable event with an overall frequency of 78% (14/18) and 89% (16/18) during sedation onset and recovery, respectively. Overall, A4% administered IM in dogs at 7.5 and 10 mg kg−1 resulted in sufficient sedation for IV catheterization in dogs. To improve the speed and quality of the sedation, it is recommended that future research focuses on combining A4% with other sedative or analgesic drugs.
Whose water crisis? How policy responses to acute environmental change widen inequality
Authors: David Olivia , Hughes Sara 
Published: December 2023

AbstractPolicy responses to the challenges associated with environmental change, including more frequent and severe climatic events, have interlinked environmental and social impacts. Less attention has been afforded to the latter, and specifically to the question of not just whether but how such responses create or entrench inequality. This paper examines policy responses to drought events in California, United States, and the Western Cape Province, South Africa, in terms of their effects on inequality, revealed in relationships to water access networks. We use concepts of water justice and hydraulic citizenship to evaluate how and why these policy responses reproduced water injustices in the two settings. We focus particularly on two mechanisms linking responses to widened inequalities: values‐reinforcement and strategic communication. Using interviews, policy documents, and media reports, we employ process tracing methods to illustrate these mechanisms through which drought policy impacts hydraulic citizenship experiences, manifesting water injustice. We contribute to emerging examinations of environmental policy responses and maladaptation by demonstrating how concepts of hydraulic citizenship and an emphasis on mechanisms can help us better understand and identify experiences of water injustice. We note policy implications and areas for future research, highlighting droughts as consequential policy sites for advancing social and environmental justice.
Boundedness in families with applications to arithmetic hyperbolicity
Authors: van Bommel Raymond , Javanpeykar Ariyan , Kamenova Ljudmila 
Published: December 2023

AbstractMotivated by conjectures of Demailly, Green–Griffiths, Lang and Vojta, we show that several notions related to hyperbolicity behave similarly in families. We apply our results to show the persistence of arithmetic hyperbolicity along field extensions for projective normal surfaces with non‐zero irregularity. These results rely on the mild boundedness of semi‐abelian varieties. We also introduce and study the notion of pseudo‐algebraic hyperbolicity which extends Demailly's notion of algebraic hyperbolicity for projective schemes.
Simulated altitude is medicine: intermittent exposure to hypobaric hypoxia and cold accelerates injured skeletal muscle recovery
Authors: Santocildes Garoa , Viscor Ginés , Pagès Teresa , Torrella Joan Ramon 
Published: December 2023

AbstractMuscle injuries are the leading cause of sports casualties. Because of its high plasticity, skeletal muscle can respond to different stimuli to maintain and improve functionality. Intermittent hypobaric hypoxia (IHH) improves muscle oxygen delivery and utilization. Hypobaria coexists with cold in the biosphere, opening the possibility to consider the combined use of both environmental factors to achieve beneficial physiological adjustments. We studied the effects of IHH and cold exposure, separately and simultaneously, on muscle regeneration. Adult male rats were surgically injured in one gastrocnemius and randomly assigned to the following groups: (1) CTRL: passive recovery; (2) COLD: intermittently exposed to cold (4°C); (3) HYPO: submitted to IHH (4500 m); (4) COHY: exposed to intermittent simultaneous cold and hypoxia. Animals were subjected to these interventions for 4 h/day for 9 or 21 days. COLD and COHY rats showed faster muscle regeneration than CTRL, evidenced after 9 days at histological (dMHC‐positive and centrally nucleated fibre reduction) and functional levels after 21 days. HYPO rats showed a full recovery from injury (at histological and functional levels) after 9 days, while COLD and COHY needed more time to induce a total functional recovery. IHH can be postulated as an anti‐fibrotic treatment since it reduces collagen I deposition. The increase in the pSer473Akt/total Akt ratio observed after 9 days in COLD, HYPO and COHY, together with the increase in the pThr172AMPKα/total AMPKα ratio observed in the gastrocnemius of HYPO, provides clues to the molecular mechanisms involved in the improved muscle regeneration.
imageKey points
Only intermittent hypobaric exposure accelerated muscle recovery as early as 9 days following injury at histological and functional levels.
Injured muscles from animals treated with intermittent (4 h/day) cold, hypobaric hypoxia or a simultaneous combination of both stimuli regenerated histological structure and recovered muscle function 21 days after injury.
The combination of cold and hypoxia showed a blunting effect as compared to hypoxia alone in the time course of the muscle recovery.
The increased expression of the phosphorylated forms of Akt observed in all experimental groups could participate in the molecular cascade of events leading to a faster regeneration.
The elevated levels of phosphorylated AMPKα in the HYPO group could play a key role in the modulation of the inflammatory response during the first steps of the muscle regeneration process.
People with IBD evidence more microarousals during sleep architecture assessments
Authors: Salwen-Deremer Jessica K , Reid Matthew J , Westvold Sarah J , Siegel Corey A , Smith Michael T 
Published: December 2023

ObjectivePoor sleep is common in inflammatory bowel disease (IBD) and may be associated with overall worse disease outcomes. While the sleep/IBD literature is growing, the data are often self-reported. Further, much of the research using objective measures of sleep architecture, or the overall pattern of sleep depth, rely on single-night assessments, which can be of questionable validity.DesignParticipants with IBD and healthy controls were recruited from Dartmouth-Hitchcock Medical Center as part of a two-phase clinical trial. Sleep architecture was assessed using three nights of in-home electroencephalographic monitoring and scored according to the American Academy of Sleep Medicine guidelines.ResultsOur sample included 15 participants with IBD and 8 healthy controls. Participants with IBD were more psychiatrically complex, with more self-reported insomnia, anxiety and depression. Participants with IBD evidenced greater microarousals than healthy controls. In participants with IBD, microarousals were associated with lower insomnia and greater depression scores. Within IBD, participants with clinically significant insomnia evidenced trend towards lower sleep efficiency, while self-reported disease activity did not significantly impact findings.ConclusionsThe methodology of past research may have impacted findings, including the reliance on single-night assessments and limited generalisability. Future research that uses robust, multinight assessments of sleep architecture in large, diverse samples is clearly warranted, as is research exploring the impact of cognitive and behavioural factors on sleep architecture and arousal.Trial registration numberNCT04132024.
What is the optimal assessment of speech? A multicentre, international evaluation of speech assessment in 2500 patients with a cleft
Authors: Ombashi Saranda , Kurniawan Melissa Srijanti , Allori Alexander , Sharif-Askary Banafsheh , Rogers-Vizena Carolyn , Koudstaal Maarten , Franken Marie-Christine , Mink van der Molen Aebele B , Mathijssen Irene , Klassen Anne , Versnel Sarah Lisa 
Published: December 2023

ObjectivesSpeech problems in patients with a cleft palate are often complex and multifactorial. Finding the optimal way of monitoring these problems is challenging. The International Consortium of Health Outcomes Measurement (ICHOM) has developed a set of standardised outcome measures at specific ages for patients with a cleft lip and/or palate, including measures of speech assessment. This study evaluates the type and timing of speech outcome measures currently included in this ICHOM Standard Set. Additionally, speech assessments in other cleft protocols and initiatives are discussed.Design, setting and participantsAn international, multicentre study was set up including centres from the USA and the Netherlands. Outcomes of clinical measures and Patient Reported Outcome Measures (PROMs) were collected retrospectively according to the ICHOM set. PROM data from a field test of the CLEFT-Q, a questionnaire developed and validated for patients with a cleft, were collected, including participants from countries with all sorts of income statuses, to examine the value of additional moments of measurement that are used in other cleft initiatives.Data from 2500 patients were included. Measured outcomes contained univariate regression analyses, trend analyses, t-tests, correlations and floor and ceiling effects.ResultsPROMs correlated low to moderate with clinical outcome measures. Clinical outcome measures correlated low to moderate with each other too. In contrast, two CLEFT-Q Scales correlated strongly with each other. All PROMs and the Percent Consonants Correct (PCC) showed an effect of age. In patients with an isolated cleft palate, a ceiling effect was found in the Intelligibility in Context Scale.ConclusionRecommendations for an optimal speech outcome assessment in cleft patients are made. Measurement moments of different cleft protocols and initiatives are considered in this proposition. Concerning the type of measures, adjustment of the current PCC score outcome seems appropriate. For centres with adequate resources and specific interest in research, translation and validation of an upcoming tool, theCleft Audit Protocol for Speech Augmented, is recommended.
South Korean Labor and Infrastructure in Saudi Arabia during the Late Cold War
Authors: Jeong Janice Hyeju 
Published: December 2023

Abstract
This article focuses on the geopolitical backdrop and the dynamics of state-private partnerships that shaped the migrations of hundreds of thousands of Korean workers who sojourned for two to three years in infrastructural construction sites across Saudi Arabia between the mid-1970s and the mid-1980s. It argues that the mobility channels between the two countries took shape not through oil and state governance alone, but also through US military complexes formed through a series of wars across East, Southeast, and West Asia following the Second World War; acute interest from the Saudi elite in finding alternative non-Western partners and in leveraging oil to promote the Palestinian cause in East Asia; and the preexisting ties between Korean business actors and their Saudi counterparts. Such migration infrastructure included direct transplantation of militarized organizational structures and residential camps from Korea to Saudi Arabia, lives behind which remained hidden from public view.
The Middle Class and the Land Struggle in Palestine
Authors: Eldin Munir Fakher 
Published: December 2023

Abstract
This article discusses the rise and failure of private horticultural farming by Palestinian leaders and middle-class developers in the Beisan valley in the 1930s. This focus broadens and deepens our understanding of the colonial encounter in Palestine. Although the Palestinian middle class appears prominently in the political narratives of the struggle, this group has been paradoxically deemphasized in the social history of capital and settler accumulation and dispossession. By correcting this bias, the article seeks to develop a more inclusive narrative concerning private property in land in the settler-colonial predicament as a process of double loss: of Indigenous land relations and ecologies, on the one hand, and national life and territory, on the other. To do so, the article privileges an actor-based history, which captures both the development of political and economic practices and traditions, as well as the long and deep effects of governmental structures of dispossession.
Health and its significance in the modern concept of wellness and spa
Authors: Kupcewicz Ewa , Bentkowska Aleksandra 
Published: December 2023

The aim of the study is to present selected issues related to health that are significant in the modern concept of wellness and spa.
The World Health Organization has adopted the so-called positive definition of health, which encompasses it as a state of complete physical, mental, and social well-being, rather than merely the absence of disease or infirmity. Wellness is one of the contemporary approaches to health related to quality of life and actions for health (aspiring towards wellness). On the other hand, spa is an idea of a holistic approach to health, where the harmony of mind and body is to be ensured through the use of relaxing, cosmetic, and biological renewal treatments, often involving water. Spa centers combine relaxation with the care for psychophysical health. The purpose of these centers is to improve health, well-being, and appearance. These aspects are extremely important in the holistic understanding of health.
Protective roles of the red-dragon fruit peels (Hylocereus costaricensis) against the cigarette-smoke harmful effect in Wistar rats
Authors: Ardhianditto Decca , Murwani Retno , Johan Andrew , Ariyanto Diaza Okadimar 
Published: December 2023

Background: Many people are exposed to cigarette smoke unintentionally in numerous places worldwide. Cigarette smoke contains carbon monoxide, nicotine, and polycyclic aromatic hydrocarbons, which are toxic and can trigger the production of free radicals in the body.Objective: To study the impact of cigarette-smoke exposure twice daily for 30 days on 4-5 weeks Rattus norvegicus L. without or with a daily intake of the juice or ethanol extract of the red-dragon fruit peels H. costaricensis. Materials and Methods: Twenty-eight 4-5 weeks old male Wistar rats were randomly allocated into Control (not exposed to cigarette-smoke), exposed to cigarette-smoke only (Csmoke), exposed to cigarette-smoke and H. Costaricensis-peel juice (JcHc), exposed to cigarette-smoke and had H. Costaricensis-peel extract (ExHc). Cigarette-smoke exposure was given twice daily. The juice (3g/mL) and extract (3.15g/mL) were given for 30 days ad libitum. Feed and drink intake, body weight, and serum biochemistry (MDA, bilirubin, ALT and AST) were determined. Data were analyzed by ANOVA.Results: The positive control group with cigarette-smoke exposure (Csmoke) had a significant elevation in serum malondialdehyde (MDA), alanine-transaminase (ALT), and aspartate-transaminase (AST) and drinking water intake (p<0.05) but reduced feed intake and body weight (p<0.05). The JcHc and ExHc groups had reduced serum MDA, ALT, and AST and higher body weight and feed intake than the Csmoke, and the extract had a better reduction than the juice (p<0.05). Furthermore, the extract had a lower biochemical profile than the Control group (p<0.05).Conclusion: The disturbance in serum MDA, ALT, AST, water and feed intake, and body weight by cigarette smoke was ameliorated by H. costaricensis peel juice or extract daily for 30 days. H. costaricensis peel juice or extract can be used to prevent the adverse effects of cigarette smoke exposure and has the potential to be developed into valuable products.
Einsatz von Kommunikationsmitteln im Auftragsabwicklungsprozess
Authors: Kruthaup Björn , Stolipin Jana , Wenzel Sigrid 
Published: December 2023

Abstract
Zur Sicherstellung eines transparenten und robusten Auftragsabwicklungsprozesses spielen produktionsrelevante Informationen eine zentrale Rolle. Der Einsatz von im jeweiligen Prozessschritt und in Abhängigkeit von den beteiligten Stakeholdern der Supply Chain geeigneten Kommunikationsmitteln schafft die Voraussetzung für die Übertragung der für den Prozess richtigen und relevanten Information und gewährleistet ihre zweckbezogene Nutzung. Der Beitrag verdeutlicht in einer Übersicht, welche Kommunikationsmittel genutzt werden, um den Auftragsabwicklungsprozess zu unterstützen. Die dargestellte Übersicht bietet im industriellen Kontext eine Grundlage für eine systematische und zielgerichtete Auswahl von Kommunikationsmitteln.
Operative Serviceplanung für Produkt-Service Systeme
Authors: Alp Enes , Schikora Niclas , Knott Marius , Kuhlenkötter Bernd 
Published: December 2023

Abstract
Immer mehr Unternehmen innovieren ihre Geschäftsmodelle und bieten Produkt-Service Systeme an. Dies ist mit verschiedenen Herausforderungen der operativen Serviceplanung verbunden. Die vorliegende Studie untersucht die Beschaffenheit der Serviceplanung in vier verschiedenen Unternehmen. Es stellt sich heraus, dass Pläne manuell erstellt werden. So beruhen die Entscheidungen in der Serviceplanung auf den subjektiven Erfahrungen der Planer, und etwaige Optimierungspotenziale werden nicht ausgeschöpft.
Effizienzsteigerung bei der Industrieroboterprogrammierung dank Kollaboration
Authors: Stepputat Marten , Beuß Florian , Sender Jan 
Published: December 2023

Abstract
Eine wirtschaftliche Programmierung von Robotern zur Kleinserienbearbeitung mit verschiedenen Werkzeugen ist nur bedingt nicht möglich. Insbesondere fehlende Qualifikationen sowie die Matrixprogrammierung zur Bauteilaufnahme und -ablage verhindern in KMU den Einsatz von Industrierobotik. In einem Forschungsprojekt wurde ein System entwickelt, welches mit Handführung, kamerabasierter Bauteilerkennung und intuitiver Nutzerführung komplexe Programmiervorgänge stark vereinfacht.
Bewertung von Produktionsstrategien in der Automobilindustrie
Authors: Hilmer Maximilian , Riedel Ralph , von Unwerth Thomas 
Published: December 2023

Abstract
Die Automobilindustrie befindet sich seit Jahren im Ausnahmezustand, da der Wechsel von einer Einheitsantriebsart hin zu einem Mix an Antriebsarten parallel zu globalen Krisen bewältigt werden muss. Der vorliegende Beitrag liefert dazu beispielhafte Betrachtungen zur indikativen Bewertung der gegensätzlichen Produktionsstrategien Mix- oder sortenreiner Produktion von Fahrzeugen mit alternativen und konventionellen Antrieben. Die Erkenntnisse können genutzt werden, um Modelle zur Wahl der richtigen Produktionsstrategien abzuleiten.
Flexible Roboterzelle für Traktionsbatterie-Demontage
Authors: Gerlitz Eduard , Fuchs Tobias , Kößler Florian , Fleischer Jürgen 
Published: December 2023

Abstract
Ein effizientes Recycling von Traktionsbatterien im Sinne der Kreislaufwirtschaft setzt eine granulare Demontage bis auf Zellebene voraus. Im folgenden Beitrag wird eine umgesetzte Roboterzelle zur Demontage von Li-Ionen-Batteriemodulen vorgestellt. Insbesondere werden erfolgreich erprobte Schlüsseltechnologien zur Realisierung der Flexibilität aufgezeigt, die für eine adaptive Roboterzelle essentiell sind. Darüber hinaus werden technologische Maßnahmen zur Flexibilisierung auf verschiedenen Ebenen diskutiert.
Kilka uwag na temat niezależności prawnomajątkowej Terencji w świetle fragmentów korespondencji Cycerona
Authors: Ejankowska Elżbieta 
Published: December 2023

Celem niniejszego artykułu jest ukazanie, na ile w okresie schyłkowym republiki możliwy był samodzielny udział kobiety rzymskiej sui iuris w obrocie prawno- majątkowym. Podstawę źródłową rozważań stanowią fragmenty korespondencji Cicerona, które dotyczą działalności gospodarczej jego żony Terencji. Jakkolwiek w niewielu listach mówcy pojawiają się informacje dotyczące tego aspektu jego małżeństwa to są one bardzo cenne, gdyż umożliwiają kolejne uzupełnienie badań nad sytuacją prawnomajątkową kobiety w państwie rzymskim. Analiza tych źródeł prowadzi do konkluzji, że – mimo ograniczeń, które wynikały z tutela mulierum – kobiety mogły brać udział w obrocie prawno – gospodarczym i samodzielnie kształtować swoje położenie majątkowe.
Between Nature and Civilization(s): American Wilderness as a Eurocentric Cultural Construct in Tony Morrison’s "A Mercy"
Authors: Vysotska Natalia 
Published: December 2023

The paper sets out to explore the ways the traditional Western opposition “nature vs. civilization” is reworked in Toni Morrison’s A Mercy. The first aspect addressed in the paper is the author’s recasting of the original Puritan myth of America as New Eden by demonstrating the historical impossibility of human-nature and human-human harmony on the “new” continent. This is achieved through presenting Jacob Vaark’s New England farm as a metaphor of Eden/enclosed garden transmogrifying from Utopian to Dystopian mode of functioning in the text, with apparent ecofeminist overtones.The second issue dealt with is “wilderness” as one of the basic concepts underlying American Puritan world picture. The paper argues that in the novel “wilderness” as an inherent characteristic of England’s transatlantic territorial expanses, including both their physical and human resources, loses its essentialism and is unmasked as a Eurocentric cultural construct. In addition, the novel extends the notion of “civilization” beyond its Eurocentric boundaries featuring two non-European civilizations – Native American and African – as suggesting alternative (and much more positive) models of “nature-civilization” relationship.
Father Porée Aporia. A Jesuit Mentor in the Struggle with the Spirit of the Nation
Authors: Любжин Алексей 
Published: December 2023

Father Charles Porée, Voltaire's teacher and lecturer in rhetoric at the Lycée Louis-le-Grand, the most prestigious secondary school in France, tried for many years to put his ethical programme into practice. He could act by personal example, by actual teaching, by directly preaching his ideas in numerous speeches and by plays for the school theatre. Putting love for God above all, love for King and fatherland in second place, and kinship love (paternal, filial, fraternal, conjugal) below, he found no place in his hierarchy for love between a man and a woman, considering it a negative value. He proposed a broad literary programme to support his views and used school theatre for the same purpose.