bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparing for the future offspring: European perch (Perca fluviatilis) biosynthesis of physiologically required fatty acids for the gonads happens already in the autumn
Authors: Rigaud Cyril , Kahilainen Kimmo K. , Calderini Marco L. , Pilecky Matthias , Kainz Martin J. , Tiirola Marja , Taipale Sami J. 
Published: November 2023

AbstractLong-chain polyunsaturated fatty acids (PUFA) are critical for reproduction and thermal adaptation. Year-round variability in the expression of fads2 (fatty acid desaturase 2) in the liver of European perch (Perca fluviatilis) in a boreal lake was tested in relation to individual variation in size, sex, and maturity, together with stable isotopes values as well as fatty acids (FA) content in different tissues and prey items. ARA and DHA primary production was restricted to the summer months, however, perch required larger amounts of these PUFA during winter, as their ARA and DHA muscle content was higher compared to summer. The expression of fads2 in perch liver increased during winter and was higher in mature females. Mature females stored DHA in their gonads already in late summer and autumn, long before the upcoming spring spawning period in May. Lower δ13CDHA values in the gonads in September suggest that these females actively synthesized DHA as part of this reproductive investment. Lower δ13CARA values in the liver of all individuals during winter suggest that perch were synthesizing essential FA to help cope with over-wintering conditions. Perch seem able to modulate its biosynthesis of physiologically required PUFA in situations of stress (fasting or cold temperatures) or in situations of high energetic demand (gonadal development). Biosynthesis of physiologically required PUFA may be an important part of survival and reproduction in aquatic food webs with long cold periods.
Rerouting in vascular access infections using a biosynthetic vascular graft (Omniflow® II)
Authors: Müller Daniel , Kohler Corinne , Weiss Salome , Widmer Matthias K. 
Published: November 2023

AbstractBackgroundSurgical treatment of infected arteriovenous grafts (AVG) while preserving the hemodialysis access remains a challenge. Partial graft excision (PGE) directly followed by interposition grafting (IG) is an established method but is associated with a high rate of local reinfection. This retrospective study investigated the technique of rerouting using a biosynthetic vascular graft (Omniflow® II).MethodsThis was a retrospective analysis of all patients at a tertiary referral center undergoing surgical treatment for AVG infections using PGE and IG with the rerouting technique using Omniflow® II between January 2009 and December 2018. Follow-up data were collected until May 2021.ResultsFifteen patients (53% male, median age 62 years [range 49-81]) were identified for further analysis, thereof twelve received an Omniflow® II vascular graft. Eleven patients had positive local microbial cultures, withStaphylococcus aureusbeing the most frequently identified pathogen (9 cases). Mortality and reoperation rates within 30 days were both 0%. Median follow-up was 32 months (range 2–101 months) with a median follow-up index of 0.92 (range 0.18–1). During follow-up a surgical intervention for reinfection was necessary in 3 patients with Omniflow® II at a median of 304 days (range 298–485 days).ConclusionPartial graft excision and direct interposition grafting using a biosynthetic Omniflow® II vascular graft is a valid treatment option in selected patients with AVG infections when total graft excision can be avoided. Using a careful rerouting technique, while preserving clinically noninfected graft sections the risk of early reinfection can be minimized and the dialysis access maintained.
The breeding ecology of the Agulhas Long-billed Lark: an endemic bird dependent on the remnant Renosterveld of the Western Cape Province, South Africa
Authors: Rose Sanjo , Thomson Robert Leslie , Lee Alan Tristam Kenneth , Ryan Peter Geoffrey 
Published: November 2023

AbstractThe Agulhas Long-billed Lark Certhilauda brevirostris is restricted to the Agulhas Plain, South Africa, a region extensively transformed for crop production and sheep grazing. We present data on nest and egg characteristics, clutch and brood size, parental care and breeding success previously undescribed for this species. During field surveys in 2020 and 2021, 29 nests were located. Of these, 16 were monitored by camera traps. Laying started in late winter (July) and continued until early summer (late November). Most nests (66%) were in Renosterveld, a unique vegetation component of the Fynbos Biome, with the remainder in human-modified landscapes. Female larks were responsible for nest construction and incubation. Both sexes provisioned nestlings, with provisioning rate related to nestling age and time of day but not brood size. Breeding success was low, with only 14% of nests fledging any young. Only one repeat nesting attempt following a predation event was observed, but the attempt was abandoned. Nest predation was the main cause of nest failure, with eight species of nest predators identified. An apparent preference for nesting in Renosterveld highlights the need for protection of this endangered habitat type. As a ground-nesting species in an agriculturally transformed landscape, this lark faces numerous threats associated with habitat loss, altered predation pressure, exposure to pesticides and disturbance at nest sites.
The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma
Authors: Qin Nan , Paisana Eunice , Picard Daniel , Leprivier Gabriel , Langini Maike , Custódia Carlos , Cascão Rita , Conrad Catleen , Peitzsch Mirko , Stefanski Anja , Stühler Kai , Fischer Ute , Faria Claudia C. , Dietrich Sascha , Reifenberger Guido , Remke Marc 
Published: November 2023

Abstract
Purpose
Primary brain tumors are a leading cause of cancer-related death in children, and medulloblastoma is the most common malignant pediatric brain tumor. The current molecular characterization of medulloblastoma is mainly based on protein-coding genes, while little is known about the involvement of long non-coding RNAs (lncRNAs). This study aimed to elucidate the role of the lncRNA OTX2-AS1 in medulloblastoma.

Methods
Analyses of DNA copy number alterations, methylation profiles, and gene expression data were used to characterize molecular alterations of OTX2-AS1 in medulloblastoma tissue samples. In vitro analyses of medulloblastoma cell models and orthotopic in vivo experiments were carried out for functional characterization of OTX2-AS1. High-throughput drug screening was employed to identify pharmacological inhibitors, while proteomics and metabolomics analyses were performed to address potential mechanisms of drug action.

Results
We detected amplification and consecutive overexpression of OTX2 and OTX2-AS1 in a subset of medulloblastomas. In addition, OTX2-AS1 promoter methylation was linked to OTX2-AS1 expression. OTX2-AS1 knockout reduced medulloblastoma cell viability and cell migration in vitro and prolonged survival in the D283 orthotopic medulloblastoma mouse xenograft model. Pharmacological inhibition of BCL-2 suppressed the growth of OTX2-AS1 overexpressing medulloblastoma cells in vitro.

Conclusions
Our study revealed a pro-tumorigenic role of OTX2-AS1 in medulloblastoma and identified BCL-2 inhibition as a potential therapeutic approach to target OTX2-AS1 overexpressing medulloblastoma cells.
Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study
Authors: da Silva Cássia Surama Oliveira , Monteiro Mussara Gomes Cavalcanti Alves , Fechine Carla Patricia Novaes dos Santos , Tavares Josean Fechine , Souto Augusto Lopes , Luna Rafaella Cristhine Pordeus , Pimenta Flávia Cristina Fernandes , e Silva Ana Herminia Andrade , da Silva Diniz Alcides , da Silva Júnior Celso Costa , Alverga Caio César Ferreira , dos Santos Sócrates Golzio , Persuhn Darlene Camati , de Carvalho Costa Maria José 
Published: November 2023

Abstract
Introduction
The prevalence of hypertension and obesity are a worldwide concern.

Objetives
Assess the metabolites profile after intervention with mixed dietary fiber in overweight and obese normotensive women.

Methods
This is a randomized double blind placebo-controlled study. Through a simple randomization process, two groups were allocated, with eleven women (group 1) receiving 12 g of mixed dietary fiber and thirteen women (group 2) receiving 12 g of placebo (corn starch) for eight weeks. Anthropometric and biochemical tests and lifestyle were analyzed. As for evaluation metabolomics, used a 1H NMR. The data matrix generated 96 samples and 225 variables, which was exported in the ASCII format for the “The Unscrumbler” statistics software (version 9.7, CAMO Process).

Results
After the intervention with mixed dietary fiber, significant differences were observed between the main types of metabolites, referring to the increase in the relative peak areas of in three HDL metabolites 4.94 ppm (0.0086*), HDL 1.28 ppm (0 .0337*), HDL 0.88 ppm (0.0224*) and an α-glucose metabolite 4.90 ppm (0.0106) and the reduction in systolic blood pressure (SBP) (0.0292*) of 7 mmHg in the reference range and in the placebo group there was a reduction in SBP (0.0118*) of 4 mmHg and of a choline metabolite 3.65 ppm (0.0266*), which does not call into question the validity of these results in the literature.

Conclusion
The synergism of the functions of these statistically highlighted metabolites contributed to prevention the increase in SBP after fiber intervention in overweight and obese normotensive women.
On a group extension involving the Suzuki group Sz(8)
Authors: Basheer Ayoub B. M. 
Published: November 2023

AbstractThe Suzuki simple group Sz(8) has an automorphism group 3. Using the electronic Atlas [22], the group Sz(8) : 3 has an absolutely irreducible module of dimension 12 over $${\mathbb {F}}_{2}.$$

F
2

.

Therefore a split extension group of the form $$2^{12}{:}(Sz(8){:}3):= {\overline{G}}$$

2
12

:

(
S
z

(
8
)

:
3
)

:
=

G
¯

exists. In this paper we study this group, where we determine its conjugacy classes and character table using the coset analysis technique together with Clifford-Fischer Theory. We determined the inertia factor groups of $${\overline{G}}$$

G
¯

by analysing the maximal subgroups of Sz(8) : 3 and maximal of the maximal subgroups of Sz(8) : 3 together with various other information. It turns out that the character table of $${\overline{G}}$$

G
¯

is a $$43 \times 43$$

43
×
43

complex valued matrix, while the Fischer matrices are all integer valued matrices with sizes ranging from 1 to 7.
Evaluation of a new topical cream to psoriasis treatment: randomized clinical trial
Authors: Benites Elizabeth , Carrillo Esmeralda , Heras Martha , Bourne Doménica 
Published: November 2023

AbstractThe aim of this study is to develop a new topical cream for psoriasis and to test its results. Experimental clinical trial. Phase I: hypersensitivity test in 100 healthy volunteers. Phase II: 120 patients, prospective, analytical differential study in hospital. In phase I, 99% health persons did not show any reaction. In phase II, the 120 patients selected in two groups, group A-new cream and group B-corticosteroid, the paired samples calculated T-value in group A was: 19.144 for erythema, 6.725 in infiltrate, 12.475 in desquamation and in pruritus 10.863, PASI 14.662 and BSA 19.083 which are higher than 1.96 the result was 0.000 less than P 0.05 highly significant after treatment group B control group, showed the T values, erythema 7.590, infiltrate 10.573, desquamation 7.311, pruritus 3.615, PASI 2.631, BSA 4.411. The T-values which are higher than 1.96 were 0.000 less than P 0.05 highly significant after treatment. In the Pearson correlation for cases and controls, association values were observed for SBA 0.042 before treatment and 0.008, after treatment, in PASI 0.021, before treatment and 0.008 after treatment. The results examined by hypotheses and cross-tabulations are highly significant in groups A and B separately, and when group A is tested against group B by means of cross-tabulations, they show differences after treatment. In the logarithmic regression for the associated risk factors, the odds ratio values of BMI 1.113>OR 1 and urea 1.439>OR 1. The elevation of these two parameters may affect the exposed group. When comparing the group, A and group B, the symptoms of erythema, infiltrate, desquamation, pruritus, PASI index and SBA were found to decrease with the group A/new cream after treatment. Further studies in larger populations are suggested, the new cream has been shown to reduce the clinical symptoms of psoriasis.
Efficient Electromagnetic Wave Absorption and Thermal Infrared Stealth in PVTMS@MWCNT Nano-Aerogel via Abundant Nano-Sized Cavities and Attenuation Interfaces
Authors: Ma Haoyu , Fashandi Maryam , Rejeb Zeineb Ben , Ming Xin , Liu Yingjun , Gong Pengjian , Li Guangxian , Park Chul B. 
Published: November 2023

AbstractPre-polymerized vinyl trimethoxy silane (PVTMS)@MWCNT nano-aerogel system was constructed via radical polymerization, sol–gel transition and supercritical CO2 drying. The fabricated organic–inorganic hybrid PVTMS@MWCNT aerogel structure shows nano-pore size (30–40 nm), high specific surface area (559 m2 g−1), high void fraction (91.7%) and enhanced mechanical property: (1) the nano-pore size is beneficial for efficiently blocking thermal conduction and thermal convection via Knudsen effect (beneficial for infrared (IR) stealth); (2) the heterogeneous interface was beneficial for IR reflection (beneficial for IR stealth) and MWCNT polarization loss (beneficial for electromagnetic wave (EMW) attenuation); (3) the high void fraction was beneficial for enhancing thermal insulation (beneficial for IR stealth) and EMW impedance match (beneficial for EMW attenuation). Guided by the above theoretical design strategy, PVTMS@MWCNT nano-aerogel shows superior EMW absorption property (cover all Ku-band) and thermal IR stealth property (ΔT reached 60.7 °C). Followed by a facial combination of the above nano-aerogel with graphene film of high electrical conductivity, an extremely high electromagnetic interference shielding material (66.5 dB, 2.06 mm thickness) with superior absorption performance of an average absorption-to-reflection (A/R) coefficient ratio of 25.4 and a low reflection bandwidth of 4.1 GHz (A/R ratio more than 10) was experimentally obtained in this work.
Twisted Integration of Complex Oxide Magnetoelectric Heterostructures via Water-Etching and Transfer Process
Authors: Yang Guannan , Dong Guohua , Zhang Butong , Xu Xu , Zhao Yanan , Hu Zhongqiang , Liu Ming 
Published: November 2023

Highlights

The (001)-oriented ferromagnetic La0.67Sr0.33MnO3 films are stuck onto the (011)-oriented ferroelectric single-crystal 0.7Pb(Mg1/3Nb2/3)O3–0.3PbTiO3 substrate with 0° and 45° twist angle.

By applying a 7.2 kV cm−1 electric field, the coexistence of uniaxial and fourfold in-plane magnetic anisotropy is observed in 45° Sample, while a typical uniaxial anisotropy is found in 0° Sample.

Abstract
Manipulating strain mode and degree that can be applied to epitaxial complex oxide thin films have been a cornerstone of strain engineering. In recent years, lift-off and transfer technology of the epitaxial oxide thin films have been developed that enabled the integration of heterostructures without the limitation of material types and crystal orientations. Moreover, twisted integration would provide a more interesting strategy in artificial magnetoelectric heterostructures. A specific twist angle between the ferroelectric and ferromagnetic oxide layers corresponds to the distinct strain regulation modes in the magnetoelectric coupling process, which could provide some insight in to the physical phenomena. In this work, the La0.67Sr0.33MnO3 (001)/0.7Pb(Mg1/3Nb2/3)O3–0.3PbTiO3 (011) (LSMO/PMN-PT) heterostructures with 45º and 0º twist angles were assembled via water-etching and transfer process. The transferred LSMO films exhibit a fourfold magnetic anisotropy with easy axis along LSMO < 110 >. A coexistence of uniaxial and fourfold magnetic anisotropy with LSMO [110] easy axis is observed for the 45° Sample by applying a 7.2 kV cm−1 electrical field, significantly different from a uniaxial anisotropy with LSMO [100] easy axis for the 0° Sample. The fitting of the ferromagnetic resonance field reveals that the strain coupling generated by the 45° twist angle causes different lattice distortion of LSMO, thereby enhancing both the fourfold and uniaxial anisotropy. This work confirms the twisting degrees of freedom for magnetoelectric coupling and opens opportunities for fabricating artificial magnetoelectric heterostructures.
Klammer zu
Authors: Eiden-Offe Patrick 
Published: November 2023

ZusammenfassungIn loser Analogie zur Geschichte der autonomen Bewegung plädiert der Beitrag für die literaturwissenschaftliche Ausarbeitung eines post-autonomen Literaturbegriffs – wobei auch die ästhetischen Wertungskriterien der Wissenschaftler*innen überarbeitet werden sollten. Mit »post-autonom« soll hier der reflektierte Austrag einiger Paradoxien des Autonomen selbst verstanden werden.
Herausforderungen hybrider Arbeitsmodelle in KMU im Vergleich zu Großunternehmen
Authors: Bath Johanna , Rieger Kathrin , Kolodziej Vanessa 
Published: November 2023

ZusammenfassungHybride Arbeitsmodelle gelten als Zukunft der Arbeit. Demnach beschäftigt sich die vorliegende Forschungsarbeit mit der Untersuchung hybrider Arbeitsmodelle im Hinblick auf deutsche kleine und mittlere Unternehmen (KMU) im Vergleich zu Großbetrieben. Mithilfe einer multi-methodischen Studie, bestehend aus einer Umfrage und qualitativen Experteninterviews, wird evaluiert, in welchem Maß hybride Arbeitsmodelle in KMU bereits etabliert sind und welche Herausforderungen sie dabei bewältigen müssen. Zusätzlich wird betrachtet, ob soziodemografische Faktoren wie Alter, Geschlecht oder Rolle im Unternehmen einen Einfluss auf hybrides Arbeiten haben.Die Ergebnisse zeigen, dass die Etablierung von hybriden Arbeitsmodellen in KMU im Gegensatz zu Großbetrieben weniger vorangeschritten ist. KMUs stehen vor vielfältigen Herausforderungen, die beispielsweise auf unzureichende Digitalisierung oder traditionellere Strukturen zurückzuführen sind. Insbesondere die Unternehmenskultur sowie die Rolle im Unternehmen und der Einfluss der Führungskraft spielen eine wichtige Rolle.Praktische Relevanz: Der Großteil vorliegender Literatur zum Thema New Work und Hybride Arbeit legt den Fokus auf die Gesamtbetrachtung aller Unternehmensgrößen oder auf Großbetriebe. Aufgrund der spezifischen Merkmale, wie beispielsweise eingeschränkter Ressourcenzugang, können Ergebnisse von Großbetrieben kaum auf KMU übertragen werden. Demnach gibt diese Arbeit eine Orientierung, wie hybride Arbeitsmodelle in KMU sinnvoll und gewinnbringend umgesetzt werden und welche Herausforderungen auftreten.
Vorgeschichte, Geschichte und Gegenwart der Empathie
Authors: Wendler Hannes 
Published: November 2023

ZusammenfassungDie Empathie zählt zu den paradigmatischen Untersuchungsgebieten der Psychologie. Im zeitgenössischen Diskurs macht sich dennoch vermehrt ein Bewusstsein breit, dass die geschichtliche Aufarbeitung des Empathiediskurses mangelhaft ist, was sich auch heutzutage noch in theoretischen Engpässen bemerkbar macht. Die vorliegende Untersuchung stellt einige historische Hintergründe bereit und nimmt Einteilungen vor, die den Empathiediskurs überschaubar machen sollen. Zunächst wird die Begriffsgeschichte von der „Einfühlung“ über „empathy“ hin zu der „Empathie“ betrachtet. Anschließend wird die Ideengeschichte in eine vorgeschichtliche Betrachtung der Romantik und des britischen Empirismus, eine geschichtliche Betrachtung von Vischers Ästhetik und Lipps Psychologie und eine zeitgenössische Betrachtung von Theorie‑, Simulations‑, Hybriden- und phänomenologischen Theorien untergliedert und entwickelt.
Differences in healthcare structures, processes and outcomes of neighbouring European countries: the example of Germany and the Netherlands
Authors: Schwettmann Lars , Hamprecht Axel , Seeber Gesine H. , Pichler Stefan , Voss Andreas , Ansmann Lena , Hoffmann Falk 
Published: November 2023

AbstractAlthough healthcare systems across Europe face rather similar challenges, their organization varies widely. Even neighbouring countries substantially differ with respect to healthcare structures, processes, and resulting outcomes. Focusing on Germany and the Netherlands as examples of such neighbouring countries, this paper will first identify and discuss similarities and major differences between both systems on the macro-level of healthcare. It further argues that it is often unknown how these differences trickle down to individual healthcare organizations, providers, patients or citizens, i.e., to the meso- and micro-level of healthcare. Hence, in a second step, potential implications of macro-level differences are described by considering the examples of total hip arthroplasty, antibiotic prescription practices and resistance, and nursing home care in Germany and the Netherlands. The paper concludes with an outlook on how these differences can be studied using the example of the project “Comparison of healthcare structures, processes and outcomes in the Northern German and Dutch cross-border region” (CHARE-GD). It further discusses potential prospects and challenges of corresponding cross-national research.
Solution of the Basel Problem in the Framework of Distribution Theory
Authors: Aste Andreas 
Published: November 2023

AbstractA simple proof of Euler’s formula which states that the sum of the reciprocals of all natural numbers squared equals $$\zeta (2)=\pi ^2/6$$

ζ

(
2
)

=

π
2

/
6

is presented based on the distribution theory introduced by Laurent Schwartz. Additional identities are obtained as a byproduct of the derivation.
Artificial intelligence in design education: evaluating ChatGPT as a virtual colleague for post-graduate course development
Authors: Meron Yaron , Tekmen Araci Yasemin 
Published: November 2023

Abstract
This article explores the ability of ChatGPT to function as a virtual colleague in helping to design materials for higher education design students. Using a self-study methodology, two university educators attempted to collaborate with ChatGPT to create course materials targeted at higher education design students, before reflecting on its strengths and weaknesses during the process. Contextualising ChatGPT as the latest acute example of digital disruptors that design practices and processes have faced, the authors evaluated its current and potential threats and opportunities for the creation of design-focused learning content. The authors found that ChatGPT was a competent partner with regard to saving time, structuring textual content and documentation, and as a brainstorming tool. However, ChatGPT’s weaknesses included content generation that was often generic, usually requiring much human prompting, cajoling, and manual editing to produce desirable outcomes. Overall, ChatGPT was found to excel at its stated functionality as a language model, with some potentially useful functionality for the creation of higher education design course materials and outlines, as well as limitations. The reflections discussed can be used to inform design educators who may want to work with ChatGPT when designing course materials. However, acknowledging limitations and potential ethical challenges, the authors’ caution that educators may have to evaluate for themselves whether ChatGPT’s potential advantages outweigh its disadvantages.