bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deprescribing medications among patients with multiple prescribers: A socioecological model
Authors: Silva Almodóvar Armando , Keller Michelle S. , Lee Jiha , Mehta Hemalkumar B. , Manja Veena , Nguyen Thanh Phuong Pham , Pavon Juliessa M. , Terman Samuel W. , Hoyle Daniel , Mixon Amanda S. , Linsky Amy M. 
Published: November 2023

AbstractDeprescribing is the intentional dose reduction or discontinuation of a medication. The development of deprescribing interventions should take into consideration important organizational, interprofessional, and patient‐specific barriers that can be further complicated by the presence of multiple prescribers involved in a patient's care. Patients who receive care from an increasing number of prescribers may experience disruptions in the timely transfer of relevant healthcare information, increasing the risk of exposure to drug–drug interactions and other medication‐related problems. Furthermore, the fragmentation of healthcare information across health systems can contribute to the refilling of discontinued medications, reducing the effectiveness of deprescribing interventions. Thus, deprescribing interventions must carefully consider the unique characteristics of patients and their prescribers to ensure interventions are successfully implemented. In this special article, an international working group of physicians, pharmacists, nurses, epidemiologists, and researchers from the United States Deprescribing Research Network (USDeN) developed a socioecological model to understand how multiple prescribers may influence the implementation of a deprescribing intervention at the individual, interpersonal, organizational, and societal level. This manuscript also includes a description of the concept of multiple prescribers and outlines a research agenda for future investigations to consider. The information contained in this manuscript should be used as a framework for future deprescribing interventions to carefully consider how multiple prescribers can influence the successful implementation of the service and ensure the intervention is as effective as possible.
Lovely heteronormative families in a harmonious society? The docudrama representations of the human‐pet relationship in contemporary China
Authors: Liu Tingting , Hu Tingting 
Published: November 2023

AbstractThis study examines docudramatic representations of human‐pet relationships in China, applying the conversational storytelling research method. The study takes Modern Furry Tale (MFT, 2021), a controversial docudrama streamed on the Tencent Video platform as its targeted case. The article argues that contemporary Chinese docudramas do not so much “document reality” as continue a “cinematic tradition” of presenting “selected reality” by showing an idealized view of the pets“ living conditions and their owners” family lives. Describing and constructing friendly and companionable pet‐human relationships, these docudramas reinforce the dominant “positive energy” state ideology, propagandistic mainstream family values, and repressive gender ideologies.
The screening and management of sleep disturbances in people living with HIV: Delphi consensus
Authors: Allavena Clotilde , Bastides Frédéric , Moroy Anne , Occhipinti Stéphanie , Durand François , Barriere Guillaume , Micoulaud‐Franchi Jean‐Arthur , Ghosn Jade 
Published: November 2023

SummarySleep disturbances in people living with HIV (PLHIV) are frequent but their management remains insufficient. In the absence of specific recommendations, a DELPHI consensus research project was conducted in France to establish best practice. A multidisciplinary Steering Committee (STC) undertook a literature review and used it with clinical expertise to create statements that were voted on. Two profiles of healthcare professionals with significant experience in monitoring PLHIV were selected for the voting: physicians and nurses/psychologists. Votes were collected electronically, independently, and anonymously. The STC created 27 statements covering six areas: Screening of sleep disturbances, Investigation, First‐line management, Referral to a specialist, Antiretroviral treatment (ARV), and Prevention. Two rounds of votes included 42 physicians and 32 nurses/psychologists. Consensus was reached for 24 out of 27 statements (89%) including: to assess quantity and quality of sleep among PLHIV at least annually, ideally using a common methodology within the medical department; to consider the temporary addition of a hypnotic treatment in cases of acute insomnia not improved by the rules of sleep hygiene, with full awareness of potential drug–drug interactions and risk of dependence; to correct ferritinaemia if <100 ng/mL before referral to a specialist when restless legs syndrome is suspected; to consider changing the time of ARV administration or an ARV switch within the same class when sleep disturbances are caused by an ARV. This DELPHI Consensus provides best practice for screening and managing sleep disturbances in PLHIV and optimising their quality of life.
Persistent left superior vena cava isolation in patients with atrial fibrillation: Selective or empirical?
Authors: Chen Jianquan , Qiu Yue , Chen Hongwu , Jin Caiyi , Wang Yuxuan , Ju Weizhu , Yang Gang , Gu Kai , Liu Hailei , Wang Zidun , Jiang Xiaohong , Li Mingfang , Wang Daowu , Chen Minglong 
Published: November 2023

AbstractBackgroundPersistent left superior vena cava (PLSVC) is the most prevalent form of thoracic venous abnormality and can serve as a significant arrhythmogenic source in atrial fibrillation (AF).Methods and resultsAmong the 3950 patients who underwent radiofrequency ablation for AF between September 2014 to April 2020, 17 patients (mean age 59.4 ± 8.0 years, 64.7% male) with PLSVC were identified. Among them, nine patients (52.9%) had a prior history of pulmonary vein isolation (PVI) alone. Eight out of nine patients who experienced AF recurrence underwent PLSVC isolation with or without pulmonary vein (PV) reconnection. For the remaining eight patients (47.1%), PVI plus PLSVC isolation were performed during the index procedure. Ectopy originating from PLSVC was documented in 11 patients (64.7%) and successful PLSVC isolation was achieved in 16 patients (94.1%). After a median follow‐up of 28.3 months, freedom from AF/ atrial tachycardia (AT) was observed in 13 patients (76.5%).ConclusionEmpirical PLSVC isolation beyond PVI appears to be a feasible and safe strategy to prevent AF recurrence in patients with concomitant PLSVC.
Sweet cherry AP2/ERF transcription factor, PavRAV2, negatively modulates fruit size by directly repressing PavKLUH expression
Authors: Qi Xiliang , Liu Lifeng , Liu Congli , Song Lulu , Dong Yuanxin , Chen Lei , Li Ming 
Published: November 2023

AbstractFor sweet cherry, fruit size is one of the main targets in breeding programs owing to the high market value of larger fruits. KLUH/CYP78A5 is an important regulator of seed/fruit size in several plant species, but its molecular mechanism is largely unknown. In this study, we characterized the function of PavKLUH in the regulation of sweet cherry fruit size. The ectopic overexpression of PavKLUH in Arabidopsis increased the size of its siliques and seeds, whereas virus‐induced gene silencing of PavKLUH in sweet cherry significantly decreased fruit size by restricting mesocarp cell expansion. We screened out an AP2/ERF transcription factor containing a B3‐like domain, designated as PavRAV2, which was able to physically interact with PavKLUH promoter in a yeast one‐hybrid (Y1H) system. In Y1H assays, electrophoretic mobility shift assays, and dual‐luciferase reporter analyses, PavRAV2 directly bound to the promoter of PavKLUH in vitro and in vivo, and suppressed PavKLUH expression. Silencing of PavRAV2 resulted in enlarged fruit as a result of enhanced mesocarp cell expansion. Together, our results provide new insights into signaling pathways related to fruit size, and outline a possible mechanism for how the RAV transcription factor directly regulates CYP78A family members to influence fruit size and development.
CsrA coordinates the expression of ribosome hibernation and anti-σ factor proteins
Authors: Pourciau Christine , Yakhnin Helen , Pannuri Archanna , Gorelik Mark G. , Lai Ying-Jung , Romeo Tony , Babitzke Paul 
Published: November 2023

ABSTRACT

Bacterial growth rate varies due to changing physiological signals and is fundamentally dependent on protein synthesis. Consequently, cells alter their transcription and translation machinery to optimize the capacity for protein production under varying conditions and growth rates. Our findings demonstrate that the post-transcriptional regulator CsrA in
Escherichia coli
controls the expression of genes that participate in these processes. During exponential growth, CsrA represses the expression of proteins that alter or inhibit RNA polymerase (RNAP) and ribosome activity, including the ribosome hibernation factors RMF, RaiA, YqjD, ElaB, YgaM, and SRA, as well as the anti-σ
70
factor, Rsd. Upon entry into the stationary phase, RaiA, YqjD, ElaB, and SRA expression was derepressed and that of RMF, YgaM, and Rsd was activated in the presence of CsrA. This pattern of gene expression likely supports global protein expression during active growth and helps limit protein production to a basal level when nutrients are limited. In addition, we identified genes encoding the paralogous C-tail anchored inner membrane proteins YqjD and ElaB as robust, direct targets of CsrA-mediated translational repression. These proteins bind ribosomes and mediate their localization to the inner cell membrane, impacting a variety of processes including protein expression and membrane integrity. Previous studies found that YqjD overexpression inhibits cell growth, suggesting that appropriate regulation of YqjD expression might play a key role in cell viability. CsrA-mediated regulation of
yqjD
and ribosome hibernation factors reveals a new role for CsrA in appropriating cellular resources for optimum growth under varying conditions.

IMPORTANCE

The Csr/Rsm system (carbon storage regulator or repressor of stationary phase metabolites) is a global post-transcriptional regulatory system that coordinates and responds to environmental cues and signals, facilitating the transition between active growth and stationary phase. Another key determinant of bacterial lifestyle decisions is the management of the cellular gene expression machinery. Here, we investigate the connection between these two processes in
Escherichia coli
. Disrupted regulation of the transcription and translation machinery impacts many cellular functions, including gene expression, growth, fitness, and stress resistance. Elucidating the role of the Csr system in controlling the activity of RNAP and ribosomes advances our understanding of mechanisms controlling bacterial growth. A more complete understanding of these processes could lead to the improvement of therapeutic strategies for recalcitrant infections.
Intracellular Dynamics of Human Cardiac Ventricular Myocyte: ORd Model
Authors: Mythri T. G. 
Published: November 2023

Human heart is elegantly articulated to mechanically contract in response to electrical excitation. Cardiac electrical activity may be described as a multiscale process from sub-cellular to cellular to tissue level. Ion movement at the cellular level through ion channels results in an action potential that propagates as an electrical wave in tissue. A first-principles-based mathematical description of the cellular-level dynamics of cardiac electrophysiological behavior provides a better understanding of the functioning of the heart. The mathematical models describing cellular dynamics often involve a coupled system of ordinary differential equations (ODEs) with variables including transmembrane voltage, ion concentrations and ion channel gating variables, whose evolution describes activation/inactivation of ion channels. In this study we discuss a mathematical model of the human ventricular myocyte (O’Hara–Rudy model), defined as a system of 41 ODEs, with variables involving membrane voltage, 29 gating variables describing activation of Na[Formula: see text], K[Formula: see text], Ca[Formula: see text] channels, 11 variables describing ion concentrations and Ca[Formula: see text] related flux. Runge–Kutta method with variable order and variable time step was adopted to solve the system numerically. We discuss the action potential (AP) profile of a healthy human ventricular myocyte and corresponding dominant ionic currents. We present a phase plot that describes the change in voltage and its rate as the system evolves over time. The phase plot seems to provide more details of the underlying events than the AP curve.
Two Decades of Church Management in the Context of Restitution Processes
Authors: Parks Tereza , Paril Vilem , Mullner Vojtech 
Published: November 2023

Abstract
This study examines the transformation of the economic relations between the state and church in the Czech Republic, focusing on changes since 2012 when a legislative framework for the separation of state and church was accepted. Our article aims to assess the changing financial relations between the church and state by emphasizing future development financial scenarios for churches in the Czech Republic based on two decades of financial data describing transfers from the public sector to the church regarding its current economic value and structure of sources. We confront quantitative results with the qualitative reflection of church representatives for whom this situation is very challenging.
The Civil Society-Military Interface in the Protection of Civilians: the Bangsamoro Case
Authors: Arcala Hall Rosalie 
Published: November 2023

Abstract
The peace process between the Philippine government and the separatist Moro Islamic Liberation Front provided breathing space for many communities and opportunities for calibrated civilian protection practices by the military and non-governmental organisations (ngo s). While the principle of non-intervention largely kept the imprint of the Association of Southeast Asian Nations (asean) to a minimum, Indonesian and Malaysian brokering enabled the establishment of bridging mechanisms such as ceasefire monitoring committees to moderate the armed violence. A more permissive environment allowed ngo s to deliver humanitarian aid and acquire improved capacities for risk mitigation in the Bangsamoro region, aided in part by a shift in the Philippine military’s approach toward putting a premium on civilian consultation and dialogue. Despite these normative gains, the uptick in horizontal violence among rival clans and the military’s preference for the use of artillery fire as a conflict de-escalation strategy create enduring challenges for civilian protection on the ground.
‘Sensing’ Learners through Presence: Learning Relational Pedagogies for Infants Using Virtual Reality
Authors: White Jayne E. , Novak Rene , Rarere-Briggs Benita , Swit Cara S. , Lukosch Heide 
Published: November 2023

Abstract
Virtual Reality (vr) is widely purported as an effective strategy for learning practical skills across disciplines such as medicine and sport, but it has yet to be fully exploited in relation to education. Learning how to engage pedagogically with students calls for sophisticated and nuanced relational skills, but opportunities to practice these with ‘real’ learners are often hard to access. This is especially so for students who are learning how to enact relational pedagogies with infants in early childhood education settings (ece) through sensing encounters. To address this lacuna, the authors co-designed and trialled a prototype for a vr game scenario that simulated ‘real-life’ presence with a virtual infant to explore its potential for learning relational pedagogies based on observable features of presence. The authors videoed the vr screen as cohorts of ece students and teachers interact with the prototype simulation and/or observed their peers. The authors found that learners quickly became sensorially engaged once they had mastered the technology. Their application and attitudes towards important features of relational pedagogies were keenly evident through these engagements – on and off the screen – with opportunities for future development identified.
Intraoperative intravenous infusion of lidocaine increases total and small vessel densities of sublingual microcirculation: a randomized prospective pilot study
Authors: Grotowska Małgorzata , Gozdzik Waldemar 
Published: November 2023

Objective Multiple organ failure can occur as a result of postoperative complications. Research has indicated that the underlying mechanism of organ dysfunction is a microcirculation disorder. Because of its antioxidant and anti-inflammatory properties, lidocaine has the potential to improve microvascular blood flow. This study was performed to assess the effect of intraoperative intravenous lidocaine infusion on the microcirculation and determine the incidence of postoperative complications. Methods In this prospective randomized double-blind pilot study, 12 patients scheduled for abdominal surgery were randomly allocated to receive an intraoperative infusion of either 1% lidocaine or the same volume of 0.9% sodium chloride solution. The microcirculation was monitored using sidestream dark-field imaging and the vascular occlusion test combined with near-infrared spectroscopy. Results Lidocaine significantly increased the total vascular density and small vessel density after 2 hours of infusion, with preservation of 99% to 100% of the capillary perfusion in both groups. No patients developed organ failure. Conclusions An increase in vessel density may be beneficial in major abdominal surgeries because it is associated with better tissue perfusion and oxygen delivery. However, this finding requires further investigation in patients with increased surgical risk. Overall, this study indicates that lidocaine has potential to improve microvascular perfusion. Research Registry number: 9549 ( https://www.researchregistry.com/browse-the-registry#home/registrationdetails/650ffd27b3f547002bd7635f/ )
A Whole Food Plant-Based Approach to Ulcerative Colitis; A Case Series
Authors: Marselou Despina , Kassam Shireen 
Published: November 2023

Inflammatory bowel disease (IBD) is a relapsing and remitting condition that requires continuous treatment to reduce the risk of relapse. Alongside genetic factors, diet and lifestyle factors are heavily implicated in the pathogenesis of the disease, with diets high in meat and ultra-processed foods and low in fibre-rich plant foods thought to be central to the disease process. There is considerable interest in using dietary interventions to prevent, treat and IBD, with the hope that this can limit and, in some cases, even eliminate the use of pharmaceutical interventions. A whole food plant-based diet (WFPBD) is an attractive option given its emphasis on foods that promote gut health and reduce inflammation and the avoidance of foods that are associated with dysbiosis and inflammation. Here we describe 3 case histories of patients with ulcerative colitis and the successful use of a WFPBD for remission induction and maintenance with over 2 years of follow-up.
Correlation between AI-based CT organ features and normal lung dose in adjuvant radiotherapy following breast-conserving surgery: a multicenter prospective study
Authors: Ma Li , Yang Yongjing , Ma Jiabao , Mao Li , Li Xiuli , Feng Lingling , Abulimiti Muyasha , Xiang Xiaoyong , Fu Fangmeng , Tan Yutong , Zhang Wenjue , Li Ye-Xiong , Jin Jing , Li Ning 
Published: November 2023

Abstract
Background
Radiation pneumonitis (RP) is one of the common side effects after adjuvant radiotherapy in breast cancer. Irradiation dose to normal lung was related to RP. We aimed to propose an organ features based on deep learning (DL) model and to evaluate the correlation between normal lung dose and organ features.

Methods
Patients with pathology-confirmed invasive breast cancer treated with adjuvant radiotherapy following breast-conserving surgery in four centers were included. From 2019 to 2020, a total of 230 patients from four nationwide centers in China were screened, of whom 208 were enrolled for DL modeling, and 22 patients from another three centers formed the external testing cohort. The subset of the internal testing cohort (n = 42) formed the internal correlation testing cohort for correlation analysis. The outline of the ipsilateral breast was marked with a lead wire before the scanning. Then, a DL model based on the High-Resolution Net was developed to detect the lead wire marker in each slice of the CT images automatically, and an in-house model was applied to segment the ipsilateral lung region. The mean and standard deviation of the distance error, the average precision, and average recall were used to measure the performance of the lead wire marker detection model. Based on these DL model results, we proposed an organ feature, and the Pearson correlation coefficient was calculated between the proposed organ feature and ipsilateral lung volume receiving 20 Gray (Gy) or more (V20).

Results
For the lead wire marker detection model, the mean and standard deviation of the distance error, AP (5 mm) and AR (5 mm) reached 3.415 ± 4.529, 0.860, 0.883, and 4.189 ± 8.390, 0.848, 0.830 in the internal testing cohort and external testing cohort, respectively. The proposed organ feature calculated from the detected marker correlated with ipsilateral lung V20 (Pearson correlation coefficient, 0.542 with p < 0.001 in the internal correlation testing cohort and 0.554 with p = 0.008 in the external testing cohort).

Conclusions
The proposed artificial Intelligence-based CT organ feature was correlated with normal lung dose in adjuvant radiotherapy following breast-conserving surgery in patients with invasive breast cancer.

Trial registration
NCT05609058 (08/11/2022).