bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of oscillations in grid cells’ toroidal topology
Authors: Sarra Giovanni di , Jha Siddharth , Roudi Yasser 
Published: January 2025

Persistent homology applied to the activity of grid cells in the Medial Entorhinal Cortex suggests that this activity lies on a toroidal manifold. By analyzing real data and a simple model, we show that neural oscillations play a key role in the appearance of this toroidal topology. To quantitatively monitor how changes in spike trains influence the topology of the data, we first define a robust measure for the degree of toroidality of a dataset. Using this measure, we find that small perturbations ( ~ 100 ms) of spike times have little influence on both the toroidality and the hexagonality of the ratemaps. Jittering spikes by ~ 100-500 ms, however, destroys the toroidal topology, while still having little impact on grid scores. These critical jittering time scales fall in the range of the periods of oscillations between the theta and eta bands. We thus hypothesized that these oscillatory modulations of neuronal spiking play a key role in the appearance and robustness of toroidal topology and the hexagonal spatial selectivity is not sufficient. We confirmed this hypothesis using a simple model for the activity of grid cells, consisting of an ensemble of independent rate-modulated Poisson processes. When these rates were modulated by oscillations, the network behaved similarly to the real data in exhibiting toroidal topology, even when the position of the fields were perturbed. In the absence of oscillations, this similarity was substantially lower. Furthermore, we find that the experimentally recorded spike trains indeed exhibit temporal modulations at the eta and theta bands, and that the ratio of the power in the eta band to that of the theta band, Aη∕Aθ, correlates with the critical jittering time at which the toroidal topology disappears.
Scrub typhus association with autoimmune biomarkers and clinical implications
Authors: You Hwanseung , Song Jeongeun , Kim Seonglyeong , Oh Sang-Min , Hwang Joo-Hee , Hwang Jeong-Hwan , Yoo Wan-Hee , Choi Yunjung , Lee Chang-Seop 
Published: January 2025

Background
Scrub typhus, a disease caused by Orientia tsutsugamushi, triggers systemic vasculitis and is prevalent in Eastern and Southern Asia. This study aimed to uncover the relationship between scrub typhus and autoimmune responses, focusing on antinuclear antibodies (ANAs) and the implications of elevated ANA titers during infection.

Method
Data from a total of 139 patients diagnosed with scrub typhus and 30 healthy controls were retrospectively analyzed through serum samples to assess the levels of ANAs and related autoantibodies. The study further examined the temporal variation of these antibody titers in relation to post-symptom progression and evaluated their association with clinical and laboratory parameters.

Results
The study results detail significant differences in autoimmune responses between scrub typhus patients and healthy controls. ANA titers above 1:80 were detected in 71.2% of patients; these titers were elevated in only 13.3% of the healthy controls. High-titer positivity (1:640 or higher) was observed exclusively in the scrub typhus group. The distribution of ANA titers revealed a progressive increase in mean ANA and double-stranded deoxyribonucleic acid Immunoglobulin M (anti-dsDNA IgM) titers as the duration after symptom onset increased, indicating an augmented immune response over time. This trend was observed along with a systematic elevation in median anti-dsDNA IgM titers, highlighting the dynamic nature of immune responses in scrub typhus infection.

Conclusion
Our findings conclude a substantial autoimmunological reaction in scrub typhus patients, suggesting potential mimicry of autoimmune conditions like Systemic Lupus Erythematosus. These results underline the complex interplay between infectious diseases and autoimmunity, emphasizing the necessity for further research into these mechanisms and their clinical implications.
Neonatal outcomes and resuscitation practices following the addition of heart rate-guidance to basic resuscitation
Authors: Patterson Jackie K. , Ishoso Daniel , Lokangaka Adrien , Iyer Pooja , Lowman Casey , Eilevstjønn Joar , Haug Ingunn , Kamath-Rayne Beena D. , Mafuta Eric , Myklebust Helge , Nolen Tracy , Tshefu Antoinette , Bose Carl , Berkelhamer Sara 
Published: January 2025

Aim
To evaluate the impact of heart rate-guided basic resuscitation compared to Helping Babies Breathe on neonatal outcomes and resuscitation practices in the Democratic Republic of the Congo.

Methods
We conducted a pre-post clinical trial comparing heart rate-guided basic resuscitation to Helping Babies Breathe in three facilities, enrolling in-born neonates ≥28 weeks gestation. We collected observational data during a convenience sample of resuscitations and extracted clinical data from the medical record for all participants. We evaluated our primary outcome of effective breathing at three minutes after birth among newborns not breathing well at 30 seconds after birth employing generalized linear models using maximum likelihood estimation.

Results
Among 1,284 newborns with observational data, there was no difference in the proportion effectively breathing at three minutes (adjusted relative risk 1.08 [95% CI 0.81, 1.45]). Among 145 receiving bag mask ventilation, time to bag mask ventilation decreased 64.3 seconds during heart rate-guided resuscitation (p<0.001). Among 10,906 enrolled in the trial, perinatal mortality was unchanged (adjusted relative risk 1.19 [95% CI 0.96, 1.48]) and death before discharge increased (adjusted relative risk 1.43 [95% CI 1.03, 1.99]). Expert review of stillborn cases demonstrated a stillbirth misclassification rate of 33.3% during Helping Babies Breathe versus 5.9% in heart rate-guided resuscitation.

Conclusion
During heart rate-guided basic resuscitation, time to bag mask ventilation was reduced by greater than one minute. The increase in death before discharge and unchanged perinatal mortality may be due to resuscitation of newborns with a higher risk of mortality who were previously presumed stillborn. A cluster-randomized trial of heart rate-guided basic resuscitation is needed to evaluate its impact on neonatal mortality in low-resource settings.
Taming the transplant troll: Exploring racial and ethnic disparities in cytomegalovirus infection among kidney transplant patients
Authors: Cabanilla M. Gabriela , Dauenhauer Ashlee , St John Briana , Hill Deirdre , Larson Joshua 
Published: January 2025

Background
Cytomegalovirus (CMV) infection poses a significant risk to kidney transplant recipients. This study investigated CMV disease incidence, outcomes, and management challenges in racial and ethnic minority populations following kidney transplantation.

Methods
This single-center, mixed-methods study included a retrospective cohort analysis of kidney transplant recipients (n = 58) and qualitative surveys of healthcare providers. Patients were categorized as minorities (n = 49) or non-Hispanic whites (n = 9). The primary outcome was CMV disease incidence. Secondary outcomes included graft failure, mortality, and identification of management barriers.

Results
The cumulative incidence of CMV disease was higher in minorities than in non-Hispanic whites (12.3% vs. 0%, p = 0.58), although the difference was not statistically significant. All graft failures (8.6%, n = 5) occurred in the minority group. Although not statistically significant, all-cause mortality was higher in the minority group (24.5% vs. 11.1%, p = 0.54), with 46.2% of the deaths occurring within 90 days of CMV diagnosis. Qualitative analysis revealed challenges in diagnosis, treatment-related side effects, medication costs, and insurance barriers. The providers emphasized the importance of interdisciplinary collaboration and standardized protocols.

Conclusion
While limited by the small sample size, this study highlights potential disparities in the incidence and outcomes of CMV disease among minority kidney transplant recipients, suggesting that barriers in care and access may contribute to these differences. These hypothesis-generating findings underscore the need for larger multicenter studies to validate these patterns and to inform targeted strategies that may reduce inequities in post-transplant outcomes.
One-minute sit-to-stand test: Reference values for the Chilean population
Authors: Otto-Yáñez Matías , Torres-Castro Rodrigo , Barros-Poblete Marisol , Barros Marcela , Valencia Carola , Campos Alex , Jadue Leticia , Puppo Homero , Serón Pamela , Vilaró Jordi 
Published: January 2025

Introduction
The one-minute sit to stand test (1min-STST) is a field test used to assess functional capacity. It is easily implementable and of significant clinical utility; however, no reference values are currently available for the Chilean population. The objective of this study was to establish reference values for the 1min-STST in a healthy Chilean population.

Methods
A multicenter cross-sectional study involving data collection from six locations in Chile was conducted. Healthy adults between 18 and 80 years of age were recruited. The anthropometric variables, levels of physical activity, smoking status, Borg scale ratings, and number of repetitions during the 1min-STST were recorded. Reference values were determined according to sex and age range.

Results
Four hundred ninety-nine healthy subjects (57.5% women, n = 287; median height, 1.63 (0.14) m; weight, 72.8 (20) kg; average BMI, 27.3 ± 4.1 kg/m2) were included in the study. The median (and the lower limit of normality (LLN) values) for the 1min-STST in men ranged from 18–29 years, with 38 (LLN 27) repetitions and 23 (LLN 15) repetitions for 70–80 years. For women aged 18–29 years, 38 (LLN 28) repetitions were performed, and for women aged 70–80 years, 24 (LLN 17) repetitions were performed.

Conclusions
This study established reference values for the healthy adult Chilean population.
Effects of cold-water immersion on health and wellbeing: A systematic review and meta-analysis
Authors: Cain Tara , Brinsley Jacinta , Bennett Hunter , Nelson Max , Maher Carol , Singh Ben 
Published: January 2025

Background
Cold-water immersion (CWI) has gained popularity as a health and wellbeing intervention among the general population.

Objective
This systematic review and meta-analysis aimed to evaluate the psychological, cognitive, and physiological effects of CWI in healthy adults.

Methods
Electronic databases were searched for randomized trials involving healthy adults aged ≥ 18 years undergoing acute or long-term CWI exposure via cold shower, ice bath, or plunge with water temperature ≤15°C for at least 30 seconds. Outcomes of interest were sleep, stress, fatigue, energy, skin health, immunity, inflammation, mental wellbeing, depression, anxiety, mood, concentration, and alertness or focus. Meta-analyses were conducted using RevMan software (version 5.4), applying random effects models to calculate standardized mean differences (SMD) between pre- and post-CWI exposure outcomes. Risk of bias was assessed using the PEDro scale.

Results
Eleven studies were included, comprising 3177 total participants and a mean PEDro score of 6.4 (n = 7 moderate quality, n = 4 high quality). CWI interventions were performed in baths (n = 10) or showers (n = 1) at temperatures ranging from 7°C to 15°C and durations ranging from 30 seconds to 2 hours. The meta-analysis revealed significant increases in inflammation immediately (SMD: 1.03, [95% CI: 0.37, 1.68], p <  0.01) and 1 hour post CWI (SMD: 1.26, [95% CI: 0.59, 1.94], p <  0.01), indicating an acute inflammatory response. A significant reduction in stress was observed 12 hours post-CWI (SMD: –1.00, [95% CI: –1.40, –0.61], p <  0.01), however, no significant effects on stress were detected immediately (SMD: –0.09 [95% CI: –0.45, 0.63], p >  0.05), 1 hour (SMD: –0.29 [95% CI: –0.66, 0.08], p >  0.05), 24 hours (SMD: –0.06 [95% CI: –0.50, 0.38], p >  0.05), or 48 hours (SMD: 0.09 [95% CI: –0.28, 0.46], p >  0.05) post-exposure. While meta-analysis showed no significant effects on immune function immediately (SMD: –0.16 [95% CI: –0.82, 0.51], p >  0.05) or 1 hour (SMD: –0.18 [95% CI: –1.09, 0.74], p >  0.05) post-CWI, narrative synthesis suggested longer-term benefits, including a 29% reduction in sickness absence among participants who took cold showers. Improvements were also observed in sleep quality and quality of life, but not mood.

Conclusions
This systematic review suggests that CWI delivers time-dependent effects on inflammation, stress, immunity, sleep quality, and quality of life, offering potential practical applications for health practitioners considering CWI for stress management and wellbeing support. However, the current evidence base is constrained by few RCTs, small sample sizes, and a lack of diversity in study populations. Future high-quality RCTs are needed to examine the long-term effects of CWI, its impact on diverse health outcomes, and optimal CWI protocols.
PROSPERO (ID: CRD42024500591)
Modified musculofascial lengthening technique for submuscular ulnar nerve transposition in cubital tunnel syndrome
Authors: So Sang-Pil , Lee Won Sun , Ku KiHyeok , Shin Young Ho , Kim Jae Kwang 
Published: January 2025

Objective
Cubital tunnel syndrome is a common peripheral neuropathy of the upper extremity. Anterior transposition of the ulnar nerve is an established surgical treatment option for this condition. This study aimed to introduce a novel musculofascial lengthening technique that uses only a portion of the flexor-pronator muscle mass for submuscular anterior transposition of the ulnar nerve and investigate its clinical outcomes.

Methods
We evaluated 28 patients (29 cases; 1 patient had bilateral involvement) diagnosed with cubital tunnel syndrome who were treated with surgical decompression and submuscular anterior transposition of the ulnar nerve using our novel technique. Mean follow-up was 19.1 months (range, 12–31). Patient-reported outcomes were assessed using the Boston Carpal Tunnel Questionnaire (BCTQ), Disabilities of the Arm, Shoulder, and Hand (DASH) Questionnaire, and numeric rating scale (NRS) for pain. Objective outcomes including light touch perception, static two-point discrimination, and grip strength were also assessed. Modified Bishop score and postoperative complications were also evaluated.

Results
BCTQ symptom severity and functional status scores, DASH score, and NRS for pain score showed significant improvement after surgery. Light touch perception, static two-point discrimination, and grip strength also significantly improved after surgery. All patients showed excellent or good results according to the modified Bishop scoring system. No recurrence or complications occurred.

Conclusion
Our novel musculofascial lengthening technique that uses only a portion of the flexor-pronator muscle mass for submuscular anterior transposition of the ulnar nerve reliably achieves good results with minimal complications in patients with cubital tunnel syndrome.
A Country Fit for Heroes: DIY Punk in Eighties Britain, Ian Glasper (2024)
Authors: Bestley Russ 
Published: January 2025

Review of: A Country Fit for Heroes: DIY Punk in Eighties Britain, Ian Glasper (2024)
Ticehurst: Earth Island Books, 686 pp.,
ISBN 978-1-91686-424-5, p/bk, £24.99
Destiny Stopped Screaming: The Life and Times of Adrian Borland, Simon Heavisides (2024)
Authors: Loydell Rupert 
Published: January 2025

Review of: Destiny Stopped Screaming: The Life and Times of Adrian Borland, Simon Heavisides (2024)
Rotterdam: Stichting Opposite Direction, 499 pp.,
ISBN 978-9-09038-083-4, p/bk, £23
Punk Revolution! An Oral History of Punk Rock Politics and Activism, John Malkin (2023)
Authors: Quinn Kevin 
Published: January 2025

Review of: Punk Revolution! An Oral History of Punk Rock Politics and Activism, John Malkin (2023)
Lanham, MD: Rowman – Littlefield Publishers, 357 pp.,
ISBN 978-1-53817-172-1, h/bk, £25
Body Mass Index Did Not Impact Efficacy and Safety of Etrasimod: A Post Hoc Analysis of the ELEVATE UC Clinical Program
Authors: Yarur Andres J. , Long Millie D. , Torres Joana , Nandi Neilanjan , Cross Raymond K. , Abbatemarco Arcangelo M. , Blanco David , Niezychowski Wojciech , Crosby Catherine , Wu Joseph , Pradeep Gokul , Goetsch Martina , Panaccione Remo 
Published: January 2025

OBJECTIVE:
High body mass index (BMI) may reduce ulcerative colitis (UC) treatment efficacy. Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active UC. This post hoc analysis assessed treatment outcomes according to BMI in ELEVATE UC 52 and ELEVATE UC 12.

METHODS:
Patients receiving etrasimod 2 mg QD or placebo were stratified by BMI: <25, 25–‍30, and >30 kg/m2. Efficacy and safety were assessed at Weeks 12 (pooled data) and 52 (ELEVATE UC 52 only) in addition to biomarkers assessments from Week 0–12.

RESULTS:
For BMI <25 (N = 443) and 25–30 kg/m2 (N = 217) subgroups, more patients receiving etrasimod vs placebo achieved clinical remission at Weeks 12 (BMI <25 kg/m2: 27.9% vs 13.3%; 25–30 kg/m2: 28.5% vs 10.0%; all P<0.001) and 52 (BMI <25 kg/m2: 30.8% vs 10.0%; 25–30 kg/m2: 33.3% vs 6.3%; all P<0.0001); and also for all other efficacy endpoints (P<0.05). In the BMI >30 kg/m2 subgroup (N = 127), more patients receiving etrasimod vs placebo achieved clinical remission at Week 52 (36.5% vs 3.9%; P<0.0001) and most other efficacy endpoints at Weeks 12 and 52 (all P<0.05). Overall, regardless of baseline BMI, numerically lower fecal calprotectin levels were observed with etrasimod vs placebo in treatment responders. The safety profile of etrasimod was consistent between BMI subgroups.

CONCLUSION:
A high BMI did not significantly impact efficacy and safety outcomes of etrasimod. (NCT03945188; NCT03996369).
Kesejahteraan Subjektif Guru Honorer: Trait dan State Syukur
Authors: Anggarani Fadjri Kirana , Andari Nabila Putri 
Published: January 2025

Amid the limitations of honorary teachers regarding welfare demands, it shows that there is still a sense of satisfaction and happiness even though the lack of income is a burden and an obstacle. These feelings indicate subjective well-being which not only influenced by material but also internal dispositions. The study aimed to examine the effect of the gratitude trait on subjective well-being directly or indirectly through the mediation of the gratitude state. Participants are honorary teachers in Surakarta with the required sample size of 122 - 144 people. Measurements were made using the subjective well-being scale, the gratitude trait scale, and the gratitude state scale. The data were tested using path analysis model regression analysis based on the procedure of the Baron & Kenny mediator. The results showed a greater role contribution to the direct effect (βc' = 0.326) of the gratitude trait on subjective well-being than the indirect effect through the mediation of the gratitude state (βab = 0.068). These results provide an overview of the subjective well-being of honorary teachers associated with the gratitude trait and the gratitude state.

Di tengah keterbatasan guru honorer terkait tuntutan kesejahteraan menunjukkan masih terdapat rasa puas dan bahagia meskipun kekurangan pendapatan menjadi beban dan hambatan. Perasaan tersebut menunjukkan kesejahteraan subjektif yang bukan hanya dipengaruhi oleh material, melainkan disposisi internal. Tujuan penelitian adalah menguji pengaruh trait syukur terhadap kesejahteraan subjektif secara langsung maupun tidak langsung melalui mediasi state syukur. Partisipan adalah guru honorer di Surakarta dengan besar sampel yang dibutuhkan sebanyak 122 - 144 orang. Pengukuran dilakukan menggunakan skala kesejahteraan subjektif, skala trait syukur, dan skala state syukur. Data diuji dengan analisis regresi model analisis jalur berdasarkan prosedur mediator Baron & Kenny. Hasil penelitian menunjukkan kontribusi peran yang lebih besar pada pengaruh langsung (βc’ =0.326) trait syukur terhadap kesejahteraan subjektif dibandingkan pengaruh tidak langsung melalui mediasi state syukur (βab =0.068). Hasil ini memberikan gambaran kesejahteraan subjektif pada guru honorer yang terkait dengan trait syukur dan state syukur.
ANALISIS BEBERAPA FAKTOR YANG BERPENGARUH TERHADAP PROSES PENGEMBANGAN KUALITAS SISTEM
Authors: Amrul Sadat 
Published: January 2025

This research test directly factors influencing for systems development quality, like: user participation, user training, user expertise, user /developer communication, user Influence, and user conflict. Persuant to answer 86 respondent employee banking industry in Banjarmasin. Result of examination of partial regretion indicate that user training and user/developer communication have an effect on positive and significant to systems development quality, while user participation, user influence, user expertise and user conflict not have an effect on by partial to systems development quality.
ENVIRONMENTAL DISCLOSURES AND EARNINGS MANAGEMENT : REVIEW AND SYNTHESIS
Authors: Sarumpaet Susi 
Published: January 2025

This paper discusses the theoretical concept of environmental disclosures and earnings management. Two theories are used in the framework, namely: fegitimacy theory and political costs theory. According to legitimacy theory, firms will disclose environmental information to their stakeholders in order to maintain legitimacy. On the other hand, political Cost theory asserts that politically visible companies (e.g. large, high profit), are vulnerable to political costs and hence will attempt to reduce the possibility of adverse political attention. In doing so, these firms may convey environmental campaigns through voluntary disclosure and, lobby the politicians by managing earnings. Previous studies have revealed consistency With the arguments above. Studies on environmental disclosures found that firms disclose environmental information to maintain legitimacy. Other studies showed that environmental disclosure is associated with size and industry sector, as the proxies for political costs. Recent investigations also found that firms engaged in earnings management in order to reduce political costs derived environmental litigations, potential environmental regulations and poor environmental performance. It is concluded that more empirical studies are needed to refine the environmental­ related earnings management area, whereas research methodology may be focused on the environmental disclosure area.
PENGARUH FATWA MUI TENTANG BUNGA BANK TERHADAP TINGKAT ABNORMAL RETURN SAHAM BANK UMUM ( Studi Kasus pada saham Bank Umum yang termasuk dalam LQ45 BEJ)
Authors: Mawardi Wisnu , Hasan Fahmi 
Published: January 2025

Fatwa MUI tentang bunga bank diprediksi oleh banyak kalangan dunia perbankan akan memperkeruh kondisi perbankan nasional yang baru bangkit setelah dihantam krisis ekonomi. Prediksi ini membuat para investor akan berpikir dua kali sebelum melakukan investasi pada saham-saham sektor perbankan. Penelitian ini memberikan gambaran aktual tentang reaksi investor pasar modal terhadap peristiwa munculnya fatwa MUI tentang bunga bank pada tanggal 16 Desember 2003 pada saham - saham sektor perbankan yang terdaftar pada LQ 45 Bursa Efek Jakarta. Pengujian dilakukan terhadap pengaruh abnormal return saham. Analisis yang dipakai menggunakan event study dengan melihat 100 hari periode estimasi dan 21 hari periode peristiwa yang terdiri 1O hari sebelum munculnya fatwa, 1 hari saat kejadian dan 10 hari sesudah fatwa tersebut dikeluarkan. Dengan menggunakan a/at analisis Uji- t. Sampel yang digunakan adalah saham perbankan yang termasuk dalam daftar indeks LQ 45 di Bursa Etek Jakarta. Hasil dari penelitian menunjukan bahwa fatwa MUI tentang bunga bank tidak menimbulkan gejolak berarti bagi perdagangan saham perbankan di pasar modal.