bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitizing Chemotherapy for Glioma with Fisetin mediated by Microenvironment-responsive Nano-drug Delivery System
Authors: Wang Wanyu , Zhang Yuanyuan , Jian Yue , He Shi , Liu Jiagang , Cheng Yongzhong , Zheng Songping , Wang Xiang , Qian Zhiyong , Gao Xiang 
Published: October 2023

Abstract
Background: Drug resistance has become an obstacle to successful cancer chemotherapies, with therapeutic agents effectively traversing the blood-brain barrier (BBB) remaining a great challenge.
Results: A microenvironmentresponsiveness and active targeting nanomicelle was constructed to enhance the penetration of drugs, leading to improved therapeutic effects. Dynamic light scattering demonstrated that prepared nanomicelle had uniform size. The cRGD modification renders the nanomicelle with active targeting capabilities to traverse BBB for chemotherapy. The disulfide-bond-containing nanomicelle can be disintegrated in response to high concentration of endogenous glutathione (GSH) within the tumor microenvironment (TME) for tumor-specific drug release, resulting in more effective accumulation. Notably, the released fisetin further increased the uptake of doxorubicin by glioma cells and exerted synergistic effects to promote apoptosis, induce cellular G2/M cycle arrest, and inhibit cell proliferation and migration in vitro. Moreover, the nanomicelle showed favorable anti-glioma effects in vivo.
Conclusions: Our study provides a new strategy to overcome drug resistance by utilizing a natural product to sensitize conventional chemotherapeutics with well-designed targeted nanodelivery systems for cancer treatment.
Improving the physical and optical characteristics of Zinc doped borate glass for bone replacement
Authors: Salatein Nahla. M. , Abdelghany A. M. , Fahim I. S. , ElHussiny F. A. , Abdou Y. 
Published: October 2023

Abstract
The presented study explores the potential of zinc-doped modified borate glass as a biomaterial for bone bonding applications. The glass samples were prepared using a melt quenching technique with a definite composition of (45-x) B2O3–24.5Na2O–24.5CaO–6P2O5–xZnO, where x = 1, 2, 5, 7.5, and 10 (wt %) and soaked in simulated body fluid (SBF) for extended periods to explore their suitability for bone bonding applications. The samples were analyzed for their structural, optical, and bioactive properties. XRD and FTIR analysis were used to examine the structural properties of the samples before and after immersion in SBF. The XRD analysis revealed that increasing the Zn content and immersion time led to the formation of a hydroxyapatite (HA) layer inside the glassy matrix, indicating improved bioactivity. The FTIR analysis showed that the addition of ZnO allowed for the conversion of tetrahedral borate units to corresponding triangular units, which improved bioactivity. Electronic spectrum measurements (UV/Vis) were used to assess the samples' optical characteristics, showing that increasing Zn content decreases the optical energy gap, indicating improved optical properties. In conclusion, this study highlights the potential of zinc-doped borate glass as a promising biomaterial for bone replacement applications. The findings indicate that by varying the Zn content, it is possible to improve the physical and optical characteristics of the glass, making it a more viable option for bone replacement. Further research is needed to optimize the composition and properties of zinc-doped borate glass and to assess its long-term performance in vivo.
Stability of Reeb Ordering by Interleaving Distance
Authors: Uda Tomoki 
Published: October 2023

Abstract

The Reeb graph is instrumental in extracting topological features from contour plots. In this context, the Reeb ordering method offers both a natural discretisation and an algorithmic approach to compute a Reeb tree. Our main theorem establishes stability within the interleaving distance among order-compatible topological spaces. Our contributions are fourfold: we construct the reflector functor for quotient structures in ordered spaces, introduce generalised trees in poset terms, define branch completeness for graph-like posets, and prove a strong normalisation theorem for posets. Furthermore, our interleaving distance metric makes our stability estimate much finer than the preceding study.
Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate
Authors: Colotti Gianni , Marrocco Francesco , Falvo Elisabetta , Mosca Luciana , Tisci Giada , Arcovito Alessandro , Bernardini Roberta , Ceci Pierpaolo , Limatola Cristina , D'Alessandro Giuseppina 
Published: October 2023

Abstract
Gliomas are among the most fatal tumors, and the available therapeutic options are very limited. Additionally, the blood-brain barrier (BBB) prevents most drugs from entering the brain.
We designed and produced a ferritin-based stimuli-sensitive nanocarrier with high biocompatibility and water solubility. It can incorporate high amounts of the potent topoisomerase 1 inhibitor Genz-644282. Here, we show that this nanocarrier, named The-0504, can cross the BBB and specifically deliver the payload to gliomas that express high amounts of the ferritin/transferrin receptor TfR1 (CD71).
Intranasal or intravenous administration of The-0504 both reduce tumor growth and improve the survival rate of glioma-bearing mice. However, nose-to-brain administration is a simpler and less invasive route that may spare most of the healthy tissues compared to intravenous injections. For this reason, the data reported here could pave the way towards a new, safe, and direct ferritin-based drug delivery method for brain diseases, especially brain tumors.
Immune-related adverse event-related adrenal insufficiency mediates immune checkpoint inhibitors efficacy for cancer treatment
Authors: Zhang Shasha , Wu Jianhua , Zhao Yue , Zhang Jingjing , Zhang Xiaoyun , Wu Chensi , Zhang Zhidong , Guo Zhanjun 
Published: October 2023

Abstract
Purpose
Immune checkpoint inhibitors (ICIs) have significantly improved the outcomes of patients with cancer. An increasing number of immune-related adverse events (irAEs) have been discovered with the widespread clinical application of ICIs, which appear to be associated with improved treatment efficacy in certain cancers. We aimed to evaluate the correlation between irAE-related adrenal insufficiency (AI) and ICI treatment efficacy.
Methods
Patients were divided into irAE-A (patients with irAE-related AI), irAE-B (patients with other irAEs) and non-irAE groups. Immunotherapy efficacy was assessed based on the disease control rate (DCR), progression-free survival (PFS), and overall survival (OS). Survival probabilities were estimated using the Kaplan–Meier method with the log–rank test.
Results
One hundred and ninety-two patients with cancer including gastrointestinal, respiratory, and other cancers, who received ICIs were enrolled in this study. The DCR of the irAE-A and irAE-B groups were higher than that of the non-irAE group (P < 0.05). Multiple extended Cox regression analyses showed that irAE status (irAE-A vs. non-irAE, P = 0.008; irAE-B vs. non-irAE, P = 0.020), ECOG status (P = 0.045), TNM stage (P = 0.000), and treatment line (P = 0.002) were independent predictors of PFS. Meanwhile, irAE status (irAE-A vs. non-irAE, P = 0.009; irAE-B vs. non-irAE, P = 0.013), ECOG status (P = 0.007), TNM stage (P = 0.035), treatment line (P = 0.001) and treatment modality (P = 0.008) were independent predictors for OS.
Conclusions
IrAE-related AI was significantly associated with better clinical outcomes in patients with cancer and is a potentially predictable marker for better ICI treatment efficacy.
Influence before Hiring: A Two-tiered Incentive Compatible Mechanism for IoT-based Crowdsourcing in Strategic Setting
Authors: Chattu Bhargavi , Singh Vikash Kumar 
Published: October 2023

Abstract
In this article, a crowdsourcing scenario with multiple heterogeneous tasks and multiple IoT devices is studied as a two-tiered process. In the first tier, it is assumed that a substantial number of IoT devices are not aware of the hiring process and are made aware by utilizing their social connections. Each IoT device reports a cost (private) and is strategic. For the first tier, a truthful budget feasible mechanism is proposed. In the second tier, a set of quality IoT devices is determined and each of them reports private valuation that satisfies gross substitute criteria along with its favorite bundle of tasks. The truthful mechanisms are designed independently for determining the quality of IoT devices, and for hiring them and deciding their payment. Theoretical analysis shows that the proposed mechanisms are computationally efficient, truthful, correct, and budget feasible. The simulation is done to compare the proposed mechanisms with the existing mechanisms.
The fight against malnutrition in a single-party decentralized country: the case of the Lao People’s Democratic Republic (Lao PDR)
Authors: Viphonephom Phonevilay , Kounnavong Sengchanh , Reinharz Daniel 
Published: October 2023

Abstract

Background
Lao PDR, a low-middle income country, has a higher malnutrition rate than other Southeast Asian countries. Decentralization of healthcare is a well-known determinant of the effectiveness of programs to reduce malnutrition, but no study has focused on this factor in Lao PDR.
Methods
A qualitative study was conducted based on a neo-institutional theory conceptual framework. Twenty-four semistructured interviews were performed with actors from different government levels, external donors and civil society. The information obtained from the interviews was supplemented with an analysis of relevant documents. Data were analyzed using NVivo 11 software. The validity of the results was ensured through credibility, transferability, reliability and confirmability.
Results
The services in charge of combating malnutrition in Lao PDR remain largely centralized, despite factors specific to the country that are leading it to promote a certain decentralization of its services. The coherence between the observed structure and the interpretative schemes of the actors concerned, at all levels of governance, ensures the stability of this state of centralization, which has persisted for almost 50 years. However, the socioeconomic changes that the country is undergoing suggest that the centralized structure will become more decentralized in the near future.
Conclusion
The centralization of public programs such as the fight against malnutrition is expected in countries whose system is based on the concept of democratic centralism and that lack expert resources capable of working regionally. However, the institutional environment in which Lao health services are offered is changing. Socioeconomic changes are expected to increase the capacity of public health professionals at regional levels to take more responsibilities in the near future. As a result, the health care structure underlying public health programs such as nutrition programs may become less centralized.
Ancient origin of the rod bipolar cell pathway in the vertebrate retina
Authors: Yoshimatsu Takeshi ,   Ayana Hellevik1, Mardoum Philip , Hahn Joshua , Kolsch Yvonne ,   Florence D’Orazi1, Suzuki Sachihiro , Godinho Leanne , Lawrence Owen , Rieke Fred , Shekhar Karthik , Sanes Joshua , Baier Herwig , Baden Tom , Wong Rachel 
Published: October 2023

Abstract

Vertebrates rely on rod photoreceptors for vision in low-light conditions. Mammals have a specialized downstream circuit for rod signaling called the primary rod pathway, which comprises specific cell types and wiring patterns that are thought to be unique to this lineage. Thus, it has been long assumed that the primary rod pathway evolved in mammals. Here, we challenge this view by demonstrating that the mammalian primary rod pathway is conserved in zebrafish, which diverged from extant mammals ~400 million years ago. Using single-cell RNA-sequencing, we identified two bipolar cell (BC) types in zebrafish that are related to mammalian rod BCs (RBCs) of the primary rod pathway. By combining electrophysiology, histology, and ultrastructural reconstruction of the zebrafish RBCs, we found that, like mammalian RBCs, both zebrafish RBC types connect with all rods in their dendritic territory, and provide output largely onto amacrine cells. The wiring pattern of the amacrine cells post-synaptic to one RBC type is strikingly similar to that of mammalian RBCs, suggesting that the cell types and circuit design of the primary rod pathway have emerged before the divergence of teleost fish and amniotes. The second RBC type, which forms separate pathways, is either lost in mammals or emerged in fish.
Anthracycline-induced myocarditis following Ewing/PNET sarcoma treatment: A case report
Authors: Emami Amir hossein , Alizadehasl Azin , Sayad Masoud , Shavandi Farnaz , Firoozbakhsh Parisa , Meshgi Shahla , Roudini Kamran , Hesami Mahshid , Shiravi Masoumeh , Dokhani Negar 
Published: October 2023

Abstract
Background
Extra-osseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is a rare neoplasm that typically affects children. The treatment of choice for this neoplasm is the VAC/IE regimen, which includes doxorubicin. Cardiotoxicity is the prominent side effect of anthracyclines, and myocarditis is an uncommon adverse effect, usually occurring idiosyncratically and being reversible.
Case Presentation
In the current study, we report the case of a 19-year-old female with a mass on the abdominal wall diagnosed with ES/PNET. She was treated with the VAC/IE regimen. A month after the last session of chemotherapy, she experienced dyspnea. Upon evaluation, a high level of troponin and a low left ventricular ejection fraction (LVEF) were detected on transthoracic echocardiography. She was treated with anti-heart failure drugs, but the response was not satisfactory. The possibility of anthracycline-induced myocarditis was suspected, and cardiac magnetic resonance imaging (CMR) confirmed acute myocarditis. This patient exhibited a significant response to intravenous immunoglobulin (IVIG), with her LVEF improving from 20–25–45% within three months.
Conclusion
In this case, anthracycline-induced myocarditis was reversible with accurate diagnosis and treatment, showing a remarkable response to IVIG, which is a favorable treatment for myocarditis in younger patients.
Influence of Variation of Habitat, Season and Prey on the Distribution and Diversity of Reduviid Predators (Hemiptera:Reduviidae) in Southern Western Ghats of Tamil Nadu
Authors: Madasamy Muthupandi , Arokiyaraj Manimaran , Soosaimanickam Maria Packiam 
Published: October 2023

Abstract
Distribution and diversity of reduviid predators (Reduviidae) were recorded from Killikulam semi-arid zone (SAZ), Aralvoimozhi scrub jungle (SJ) and Godayar tropical forest (TF) of Southern Western Ghats, Tamil Nadu, India for 12 months (September 2019to August 2020) to record the dominant predator species which can be utilized as a biocontrol agent of agricultural/forest insect pests. In total 641 individuals, belonging to 7 sub-families, 24 genera and 31 species were recorded from the study regions. More number of species were recorded in SJ (22) compared to SAZ (13) and TF (09). The predator population was high during winter and summer in semi-arid zone, scrub jungle and tropical forest respectively. The most dominant reduviids were Edocla slateri Distant and Rhynocoris fuscipes (Fab.) (50%) than Acanthapis pedestris Stal and Catamirus brevipennis Servile (44.4%) and Irantha armipes (38.9%) in Southern Western Ghats and these reduviids can be utilized in the post management programme. SJ showed higher Shannon-Weiner index (2.552) than Simson’s index (0.146). In general, specific prey population regulates particular reduviid irrespective of the habitat of the Southern Western Ghats.
The influence of climate change on the distribution of the Oak Processionary Moth in Bavaria
Authors: Rosemann Scarlett , Rosemann Bernd 
Published: October 2023

Abstract
The Oak Processionary Moth (OPM) is a heat-loving moth native to the warmer regions of southern Europe, with an increasing range in central Europe. Its caterpillars, living in gregarious aggregations, can cause defoliation of infested trees. The OPM is of particular concern. Stinging hairs of its caterpillars can cause allergic reactions through the skin and respiratory tract. The hypothesis being discussed is that increasing warming caused by climate change favours the spread of thermophilic moths. The study is geographically focused on the Free State of Bavaria/Germany, where the pest first became known in the 1990s. Bavaria's natural forest communities historically contain a high proportion of broadleaved oaks. Because oaks thrive in warm, dry forest landscapes, they are in suspicion promoting the distribution of the OPM. Beside oaks are hosting the OPM, they offer hope for climate-adapted forest conversion because of their good climate resilience. The hypothesis is tested through a systematic study of the habitat characteristics of OPM habitats by matching factors influencing population dynamics with time series of geographically referenced population data. The analysis precedes an extensive literature review and uses OPM population and climate science time series. The results provide fitting data to support the hypothesis. Population dynamics show a high correlation with climate warming parameters, but global warming is not the only factor. The implications for OPM population trends summarise and complement the current state of knowledge and provide a strong rationale for more in-depth research into scenarios for future population trends using geo-databased climate projections, forest history, site and silvicultural data to provide a assured assessment for the long-term success of the 'oak tree' under the threat of increasing infestation by the Oak Processionary Moth.
Personalised Electric Vehicle Charging Stop Planning Through Online Estimators
Authors: Shafipour Elnaz , Stein Sebastian , Ahipasaoglu Selin 
Published: October 2023

Abstract

In this paper, we address the problem of finding charging stops while travelling in electric vehicles (EVs) using artificial intelligence (AI). Choosing a charging station is challenging, because drivers have very heterogeneous preferences in terms of how they trade off the features of various alternatives (for example, regarding the time spent driving, charging costs, waiting times at charging stations, and the facilities provided at the charging stations). The key problem here is eliciting the diverse preferences of drivers, assuming that these preferences are typically not fully known a priori, and then planning stops based on each driver's preferences. Our approach to solving this problem is to develop an intelligent personal agent that learns preferences gradually over multiple interactions. This study proposes a new technique that utilises a small-scale discrete choice experiment as a method of interacting with the driver in order to minimise the cognitive burden on the driver. Using this method, drivers are presented with a variety of routes with possible combinations of charging stops depending on the agent's latest belief about their preferences. In subsequent iterations, the personal agent will continue to learn and refine its belief about the driver's preferences, suggesting more personalised routes that are closer to the driver's preferences. Based on real preference data from EV drivers, we evaluate our novel algorithm and show that, after only a few queries, our method quickly converges to the optimal routes for EV drivers.
Performa Metode Elastic-Net dalam Kasus Multikolinearitas pada Analisis Linear Berganda
Authors: Sinaga Hizkia Edwar , Saputro Dewi Retno Sari 
Published: October 2023

Analisis linear berganda umum digunakan untuk menganalisis data dengan variabel yang banyak. Selama proses menganalisa terdapat masalah umum yang sering dijumpai yaitu multikolinearitas. Multikolinearitas dapat diartikan sebagai adanya korelasi antara dua atau lebih variabel bebas. Multikolinearitas dapat dideteksi dengan cara: menghitung koefisien korelasi antara sesama variabel bebas, menghitung nilai Variance Inflation Factor (VIF), menghitung nilai TOL yaitu suatu ukuran tolerance untuk deteksi multikolinearitas, dan menghitung Condition Number (CN). Multikolinearitas dapat diatasi dengan cara: menambah data baru, menerapkan analisis komponen utama, menggunakan regresi gulud, menggunakan metode LASSO, dan menggunakan metode Elastic-Net. Metode Elastic-Net merupakan salah satu cara terbaik yang dapat digunakan. Elastic-Net menggabungkan penalti penyusutan regresi gulud dan LASSO sehingga membuatnya lebih efisien. Apabila 0, penalti penyusutan Elastic-Net menjadi penlati penyusutan regresi gulud. Apabila 1, penalti penyusutan Elastic-Net menjadi penaltipenyusutan LASSO. Hasil penelitian menunjukkan performa metode Elastic-Net dapat menangani multikolinearitas pada analisis linear berganda.
Kata kunci: Analisis Linear Berganda, Multikolinearitas, Elastic-Net
Sociodemographic Profile, Health Conditions, and Burden of Informal Caregivers of Older Adults in Brazil During the COVID-19 Pandemic: Cross-Sectional, Exploratory, Noninterventional, Descriptive Study
Authors: Ferreira Pâmela Moraes , Gomes Mateus Cunha , de Araujo Lucianne Nascimento , Oliveira Tainá Sayuri Onuma de , Ferreira Glenda , Aben-Athar Cintia , da Silva Silvio Eder Dias , Cruz Ramos Aline M P , Rodrigues Diego Pereira , Sousa Fabianne 
Published: October 2023

Background
Demographic changes in the world population have resulted in an increasingly aging society, with a progressive increase in the number of people in situations of dependence, who require assistance from family members to meet their basic needs. Caring for older adults involves performing diverse activities, resulting in reduced free time and tiredness, and fulfilling the demands and expectations related to personal, family, physical, and social life, consequently compromising the quality of life of the caregiver. In this context, the informal caregiver of hospitalized older adults emerges as the focus of attention.

Objective
The aim of this study was to describe the sociodemographic profile, health conditions, and burden of informal caregivers of older adults admitted to a university hospital in Brazil during the COVID-19 pandemic period.

Methods
This is a cross-sectional, descriptive, and analytical study that was conducted with 25 informal caregivers of hospitalized older adults in a university hospital in Brazil between August and September 2022. Three instruments were applied: Caregiver Burden Inventory, sociodemographic questionnaire, and health conditions questionnaire. The data were analyzed using SPSS version 28.0. Descriptive (frequency and percentage) and inferential analyses were performed using 2-sided Student t test with 95% CIs.

Results
Of the 25 interviewees, 18 (72%) were females, 17 (46%) were married or in a stable union, 14 (56%) completed secondary education, and 11 (44%) lived with the older adults who needed care. The average age of the participants was 44 (SD 12.8) years. Regarding their health conditions, most caregivers self-reported it as good (12/25, 48%). They provided care to their father or mother older than 70 years (14/25, 56%). The Caregiver Burden Inventory analysis showed that the caregivers were the most negatively impacted in the domains of personal life overload (mean 10.8, SD 3.46; P=.047) and physical overload (mean 10.6, SD 2.32; P=.02).

Conclusions
In recent years, there has been an increase in the burden on informal caregivers of hospitalized older adults in Brazil, thereby impacting their personal and physical lives. The findings of our study show that health care professionals should be trained to promote health guidelines and actions to improve the personal and physical lives of the caregiver population in Brazil.