bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on the Drug Utilization Evaluation of Antiepileptics among the Pediatric Patients at an Indian Tertiary Care Hospital
Authors: Guttula Sunil Paul , Raju MS , Jemini Charan K , Loko Theophilus Adeyi , Kojo Basagnia Emmanuel 
Published: December 2023

Aim: The main of the study is to evaluate the drug utilization pattern of antiepileptics among the pediatric patients at an Indian tertiary care hospital.
Materials and Methods: This was a prospective study. In-patients who were having seizures with infant (1 month - 2 years), children (2-12 years) and adolescent (12-16 years) age groups were included in this study. Out-patients and patients with brain tumors were excluded from the study.
Results: A total of 200 study participants were involved in this study and among them, 117 (58.5%) were found to be males and 83 (41.5%) were found to be females. Among the 200 study participants, 149 (74.5%) were prescribed with monotherapy, 38 (19%) were prescribed with dual therapy, 9 (4.5%) were prescribed with triple therapy and the remaining 4 (2%) were prescribed with other combinations. Among the study participants who were prescribed with monotherapy, Phenytoin (41.6%) was the most commonly prescribed drug followed by clobazam (24.8%) and sodium Valproate (23.5%). Phenytoin + benzodiazepine (42.1%) and sodium Valproate + benzodiazepine (31.6%) were the most commonly prescribed dual therapy drugs in this study. Sodium Valproate + Phenytoin + Levetiracetam (33.4%) and Phenytoin + Sodium Valproate + Clobazam (22.2%) were the most commonly prescribed triple therapy drugs in this study.
Conclusion: Majority of the patients were prescribed with monotherapy followed by dual therapy. Phenytoin was the most commonly prescribed drug in monotherapy whereas the combination of Phenytoin+benzodiazepine was the most commonly prescribed among the patients prescribed with dual therapy. Clinical pharmacists should involve in providing better pharmaceutical care and their involvement can improve the treatment outcomes and as well as the patient’s quality of life.
Enhancing Oral Absorption of Orlistat through Gastroretentive Mucoadhesive Pellets: Formulation and Evaluation
Authors: Thummala Uday Kumar , Vallabhareddy Prasanna Saisree , Sarella Prakash Nathaniel Kumar 
Published: December 2023

Aim: The aim of this study was to develop gastroretentive mucoadhesive pellets of Orlistat to improve its oral bioavailability and enhance its absorption.
Methods: Orlistat pellets were prepared using Hydroxy Propyl Methyl Cellulose (HPMC) K100M, Sodium Carboxy Methyl Cellulose (NaCMC), Carbopol 934P, and Polyvinyl Pyrrollidone (PVP) K30 in varying ratios. Physical characteristics of the tablets were evaluated, and compatibility studies were performed between Orlistat and the excipients. Swelling index, mucoadhesion strength and drug release were measured for each formulation. Drug release kinetics and stability studies were carried out.
Results: The combination of HPMC K100M, NaCMC, Carbopol 934P and PVP K30 provided balanced release and mucoadhesion with F13 showing sustained release up to 16 hours. The calibration curve demonstrated a good linear relationship between Orlistat concentration and absorbance over the range of 10 to 50 ?g/ml. Swelling index increased with time and polymer concentration and mucoadhesion strength increased with polymer viscosity and concentration. Drug release from formulations containing HPMC K100M, NaCMC and Carbopol 934P were 12-14 hours, 10-12 hours and 8-11 hours, respectively. Combination polymers in F10-F13 provided balanced release and mucoadhesion, with F13 showing sustained release up to 16 hours. The drug release followed zero order kinetics with non-Fickian diffusion. Stability studies on the optimized F13 formulation showed no significant changes in appearance, hardness, mucoadhesion or drug release over 3 months.
Conclusion: The combination of HPMC K100M, NaCMC, Carbopol 934P and PVP K30 improved the oral bioavailability and absorption of Orlistat. The study demonstrated the importance of compatibility studies and the use of calibration curves for quantitative analysis. The findings provide valuable insights into the development of drug delivery systems for poorly bioavailable drugs.
A Study on the Assessment of Risk in the Management of Acute Coronary Syndrome using GRACE score
Authors: H Nikhil Chandra , Govula Sindhuja , Swathi Buyyani , P Soumya 
Published: December 2023

Aim: To assess the risk in the management of acute coronary syndrome by using GRACE score.
Methods: This was an observational study conducted among 155 patients of cardiology department. Myocardial infarction patients of age above 20 years who were treated with fibronolytics were included in the study. Patients were assessed for the risk by using the GRACE (Global Registry of Acute Coronary Events) score criteria and was classified into low (?108 points), intermediate (109 to 140 points) and high (>140 points).
Results: In this study, the severity of the LV dysfunction in most of the patients was observed to be mild followed moderate and severe. Majority of the patients were observed to be with high risk 61 (39.35%) followed by low risk 49 (31.61%) and intermediate risk 45 (29.04%). Most of the patients with high risk were observed to be in the age group 61-70 years (26.23%) whereas with intermediate risk were observed to be in the age group 41-50 years (35.55%).
Conclusion: Among the mild, moderate and severe LV dysfunction, most of the patients were observed to be with high risk according to the GRACE score criteria.
PELATIHAN PEMBUATAN TEPUNG MOCAF DI DESA TANAH MERAH KABUPATEN TANA TIDUNG
Authors: Nia Kurniasih Suryana  , Hendi Lesmana  , Nizhamuddin AB  , Mardhiana  
Published: December 2023

Desa Tanah Merah merupakan salah satu desa yang ada di Kabupaten Tana Tidung. Mayoritas penduduknya bermata pencaharian di bidang pertanian baik bertani maupun nelayan, memiliki potensi sumber daya alam yang melimpah. Komoditi pertanian yang banyak diusahakan salah satunya jenis umbi-umbian yaitu singkong. Tujuan dari pengabdian ini adalah meningkatkan pengetahuan masyarakat Desa Tanah Merah dalam memanfaatkan singkong menjadi tepung mocaf dan pengolahannya menjadi beberapa jenis makanan dan memberikan keterampilan dalam pembuatan tepung mocaf dan pengolahan makanan berbahan dasar tepung mocaf. Metode dilaksanakan dengan cara edukasi dan pelatihan. Hasil pengabdian menunjukan peningkatan keterampilan dan pengetahuan masyarakat Desa Tanah Merah terkait pembuatan tepung mocaf dari singkong, peningkatan potensi ekonomi masyarakat setempat melalui pengembangan usaha tepung mocaf yang dapat memberikan nilai tambah pada hasil panen singkong.Serta meningkatkan kesadaran akan pentingnya diversifikasi pangan lokal dalam memenuhi kebutuhan masyarakat akan pangan yang lebih bergizi dan beragam.
Partisipasi Politik Pemilih Disabilitas di Provinsi Kalimantan Selatan pada Pilkada Tahun 2020
Authors: Anshari M. , Husin Husin 
Published: December 2023

<p>Dalam Undang-undang Nomor 8 Tahun 2016 tentang penyandang disabilitas, pada pasal 13 huruf (a) dinyatakan bahwa setiap penyandang disabilitas memiliki hak untuk memilih dan dipilih dalam jabatan publik dan huruf (c) memilih partai polotik dan/atau individu yang menjadi peserta pemilihan umum. Tulisan ini bertujuan untuk mengkaji partisipasi penyandang disiblitas sebagai pemilih pada pilkada di Provinsi Kalimantan Selatan Pada tahun 2020. Tulisan ini menggunakan metode deskriptif dengan pendekatan kualitatif. Hasil tulisan gambaran bahwa partisipasi politik pemilih disabilitas pada Pilkada Tahun 2020 di Provinsi Kalimantan Selatan termasuk baik dengan 3.721 pemilih setara dengan 56,31 %. Meskipun dikategorikan angka partisipasi pemilih disabilitas pada Pilkada Tahun 2020 di Provinsi Kalimantan Selatan termasuk kategori baik dan tinggi, akan tetapi angka pemilih penyandang disabilitas yang tidak mengunakan hak pilih sebanyak 2.887 pemilih setara dengan 43,69% pemilih.</p>
ANALISIS CERITA-CERITA RAKYAT KALIMANTAN SELATAN DALAM KONTEKS KONSTRUKSI PERILAKU RELIGIUS PADA ANAK USIA DINI
Authors: Husin Gt. Muhammad Irhamna 
Published: December 2023

<p>Belakangan ini berbagai persoalan bermunculan sebagai bentuk dari perkembangan zaman. Salah satu bentuk perkembangan zaman yang memiliki dampak negatif adalah kemerosotan moral pada generasi penerus bangsa. Perilaku bertentangan dengan nilai-nilai agama begitu dekat dengan anak. Anak mulai meniru perilaku negatif seperti ujaran kebencian, kurang sopan saat berbicara. Meniru keburukan sudah menjadi kesukaan. Membentuk karakter anak pada usia dini sangat penting. Pendidik dapat memperkuat nilai-nilai agama dan moral melalui pembelajaran yang mendalam, contoh teladan yang baik, dan pendekatan komunikatif untuk menyampaikan pentingnya perilaku sesuai dengan nilai-nilai tersebut. Dukungan dari orang tua juga memegang peranan penting dalam membentuk moral anak melalui cerita rakyat. Penelitian ini membahas tentang cerita-cerita lokal Kalimantan Selatan yaitu dengan cerita kisah Datu Pemberani, legenda telaga alam banyu batuah, dan kisah Datu Diyang. Tujuan dari penelitian ini adalah untuk menganalisis dan mendeskripsikan nilai moral dalam cerita lokal untuk menanamkan nilai moral pada anak usia dini. Metode yang digunakan adalah library reseach dengan jenis penelitian analisis buku dengan sumber data diperoleh dari google scholar. Teknik analisis data yang dilakukan dalam penelitian kepustakaan ini adalah analisis data model Miles dan Huberman. Langkah yang dilakukan peneliti adalah dengan mengumpulkan berbagai data yang ditujukan untuk mencari fokus atau inti penelitian. Lalu setelah proses pengumpulan data selesai, data yang terkumpul selanjutnya dianalisis dengan menghubungkannya satu sama lain. Hasil dari penelitian ini adalah diperoleh adanya nilai-nilai moral semangat membela tanah air, pemberani, tawakal, gotong royong, kepemimpinan, ramah, tolong menolong, syukur, dermawan, pengorbanan, cinta alam, kesabaran, kasih sayang, percaya hal-hal gaib dalam cerita rakyat Kalimantan Selatan.</p>
The analysis of strategies of coping with stress of nurses working in isolation wards during the COVID-19 pandemic
Authors: Lemska Magdalena Ewa , Kretowicz Katarzyna , Ronkowska Julita 
Published: December 2023

WprowadzenieStres można zdefiniować jako negatywną reakcję organizmu na sytuację, która zakłóca jego naturalną równowagę. Wybuch pandemii COVID-19 i sposób, w jaki zmieniła ona nasz świat, stał się czynnikiem zdecydowanie stresogennym. Grupą szczególnie narażoną na zakażenie wirusem Sars-CoV-2 oraz na wysoki poziom stresu w okresie pandemii była grupa pielęgniarek i pielęgniarzy, którzy stali na pierwszej linii frontu walki o ludzkie życie.CelCelem pracy była analiza strategii radzenia sobie ze stresem wśród pielęgniarek i pielęgniarzy zaangażowanych w pracę oddziałów zakaźnych w dobie pandemii COVID-19.Materiał i metodyGłównymi metodami użytymi dla potrzeb pracy były metoda szacowania oraz metoda sondażu diagnostycznego. Metodą pomocniczą w pracy była metoda analizy piśmiennictwa. W celu uzyskania materiału do badań przeprowadzono badanie ankietowe online w 2021 r. z wykorzystaniem autorskiego kwestionariusza ankiety oraz inwentarza do pomiaru radzenia sobie ze stresem mini-COPE. Uzyskano 201 odpowiedzi. Udział w badaniu był dobrowolny, a odpowiedzi w pełni anonimowe.Wyniki i ich omówienieBadanie własne wykazało, że poziom stresu przed pandemią był istotnie niższy niż w trakcie jej trwania. Na ocenę poziomu stresu przed i w trakcie pandemii wpływ miały takie czynniki, jak płeć, wiek i staż pracy. Kobiety częściej wykazywały wyższy poziom stresu w trakcie pandemii. W badaniu autorskim dominującym stylem radzenia sobie ze stresem wśród respondentów był styl aktywnego radzenia sobie. Wraz z wiekiem badanych wzrastała częstotliwość wyboru strategii aktywnego radzenia sobie ze stresem.Wnioski1. Dominującym stylem radzenia sobie ze stresem wśród respondentów był styl aktywnego radzenia sobie.
2. Wraz z wiekiem badanych wzrastała częstość wyboru stylu aktywnego radzenia sobie w sytuacji stresowej.
ENDOVASCULAR TREATMENT OF SUPERIOR VENA CAVA SYNDROME : A SYSTEMATIC REVIEW
Authors: Atin Fulgensius , Prasetyanto R. Dhany , Johana Tiluata Leonora , Alexander Nick , Valerie Gunawan Alyssa Claudia , Kurniawan Sudargo Giovanni 
Published: December 2023

Background: Endovascular stenting has been used to manage superior vena cava syndrome for several decades and has become standard firstline practice. Superior vena cava (SVC) syndrome is caused by the obstruction of the SVC and can result in significant morbidity and mortality. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of cthe requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Result: In the PubMed database, the results of our search brought up 292 articles, whereas the results of our search on SagePub brought up 315 articles. The results of the search conducted for the last year of 2013 yielded a total 163 articles for PubMed and 127 articles for SagePub. In the end, we compiled a total of 6 papers, 4 of which came from PubMed and 2 of which came from SagePub. We included six research that met the criteria. Conclusion: In summary, this review confirms the effectiveness of endovascular stenting in managing SVCS. Further directions of research may include specific outcomes of endovascular stenting in benign SVCS, and the impact of procedural characteristics, such as the use of anticoagulation and type of stent used, on outcomes.
PERIOPERATIVE OUTCOMES OF COMBINED HEART SURGERY AND LUNG TUMOR RESECTION : A SYSTEMATIC REVIEW
Authors: Atin Fulgensius , P. Sintoro Henry , Valerie Gunawan Alyssa Claudia 
Published: December 2023

Background: Cancer and cardiovascular disease are the leading causes of death in both men and women worldwide. There are concerns regarding the potentially increased mortality and complication rates of simultaneous surgery and the adequacy of lung exposure during heart surgery.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of cthe requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 14 articles, whereas the results of our search on SagePub brought up 91 articles. The results of the search conducted for the last year of 2013 yielded a total 9 articles for PubMed and 23 articles for SagePub. In the end, we compiled a total of 5 papers, 4 of which came from PubMed and 1 of which came from SagePub. We included five research that met the criteria.
Conclusion: In summary, combined heart surgery and lung tumor resection had a low mortality rate and an acceptable complication rate. Subgroup analyses revealed that most patients with lung cancer underwent uncompromised anatomical resection and mediastinal lymph node sampling or dissection during combined cardiothoracic surgery, and showed off-pump CABG may reduce the complication rate compared with on-pump CABG. Further researches are still needed to verify these findings.
ASSOCIATION VITAMIN D TO GLAUCOMA: A SYSTEMATIC REVIEW
Authors: Valerie Gunawan Alyssa Claudia , Caesari Putri Aquirina , Stephanie Tandipayuk Anggia Dwi , Atin Fulgensius 
Published: December 2023

Background: Glaucoma is a chronic progressive optic neuropathy that causes irreversible damage. Therefore, early diagnosis and appropriate treatment to control various risk factors associated with glaucoma are important. Risk factors associated with the development of glaucoma have been reported by many researchers and include both ocular and non-ocular (systemic) factors such as myopia, central corneal thickness, disc hemorrhage, and genetic factors.
The aim: This study aims to show association vitamin D to glaucoma.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 89 articles, whereas the results of our search on SagePub brought up 98 articles. The results of the search conducted for the last year of 2013 yielded a total 13 articles for PubMed and 26 articles for SagePub. The result from title screening, a total 2 articles for PubMed and 18 articles for SagePub. In the end, we compiled a total of 10 papers. We included five research that met the criteria.
Conclusion: Decreased serum 25-OHD concentration was associated with the presence but not the severity of POAG. It was suggested that Vitamin D deficiency should be considered a potential risk factor for the development of open-angle glaucoma.
Disenchantment and Remolding: the Influence of Luxury Live Streaming on Consumer Brand Goodwill
Authors: Li Jiaxin 
Published: December 2023

As the COVID-19 epidemic is over, the global luxury market is gradually recovering. The arrival of the Internet era has provided people with a new consumption mode, and the rise of various online shopping platforms has injected new vitality into this market. Brand is the core of luxury consumption culture. Luxury brands have been tasked with constructing international brands by constructing brand awareness and boosting brand goodwill, due to the intensifying rivalry in the market. In 2020, China's live-streaming e-commerce companies have officially started the journey of luxury brands. An urgent issue in the luxury sector is to find a way to direct shoppers to build brand recognition and strengthen brand identity. Luxury goods have always been a high-end route, and whether live streaming e-commerce can improve the brand tonality and consumers' love for the brand is also an important topic continuously discussed in recent years. Through empirical analysis in this paper, it is concluded that live streaming e-commerce plays a positive role in promoting the goodwill of luxury brands.
The sacred space of the Yenisei North in virtual projects
Authors: Dvoretskaya Anna Pavlovna , Pikov Nikita Olegovich , Slabukha Aleksandr Vasil'evich , Mekhovskii Vadim Aleksandrovich 
Published: December 2023

The historical and cultural heritage of the Yenisei North has been formed over several centuries. The article provides recommendations on the use of new methods related to the graphic, digital reconstruction of unique sacred objects of Russian old-timers of the Yenisei North. The novelty of the research lies in the fact that the article for the first time analyzes the results of research and design work with cultural heritage, its presentation by means of 3D modeling and the creation of virtual tours of the Siberian Federal University, since 2009. The author's developments on modeling the lost objects of Yeniseisk and the Lower Angara region, prepared on the basis of photographic documents and scientific and technical information, are analyzed. The information potential of panoramic photography of more than 20 objects of religious heritage of the Yenisei North, the territory of the primary settlement of Russians in Eastern Siberia is revealed. Using the example of the information system of the Siberian Federal University "SACRA", developed by the authors, a classification description of objects and methods for providing distributed access to data on sacred objects to representatives of the professional community and a wide audience are proposed. It is concluded that such a digital platform allows to reveal the cultural potential of the Yenisei North, expands the possibilities of branding the territory, promotes the popularization of the historical and cultural heritage of the most remote territories, and increases historical knowledge about individual objects. New digital technologies make it possible to create aesthetically outstanding visualizations while preserving the historical authenticity of the reconstructed objects. In addition, it remains possible to introduce interactive technologies and publish virtual reconstruction on the Internet. The created virtual "product" has the possibility of long-term improvement, it is designed for development, expansion and possible correction.As new sources, historical information, artifacts are revealed, as well as new technological opportunities appear, the already created digital complex of the sacred space of the Yenisei North will receive both updated content and an updated creative form of presentation.
Ceremonias y Símbolos: Aportes al Diálogo Interreligioso en la Educación Intercultural
Authors: Sepúlveda Pizarro Jéssica , Ortiz Chavez Conny , Carihuentro Millaleo Sergio , Castillo Muñoz Andrea 
Published: December 2023

El presente artículo tiene como objetivo mostrar los principales resultados del trabajo de sistematización sobre la experiencia de convivencia interreligiosa del establecimiento educacional católico, Liceo Intercultural Técnico Profesional Guacolda. Específicamente, se centra en la participación del estudiantado en las ceremonias de dos tradiciones religiosas y su posible influencia en la apertura al diálogo interreligioso. El interés temático obedece a que una de las características fundamentales del establecimiento educacional y que define su identidad como proyecto educativo intercultural, es la realización de ceremonias religiosas católicas y mapuches[1], las cuales presentan dos aspectos distintivos: poseen un fundamento técnico - curricular, y, segundo, su autenticidad al seguir los protocolos rituales de cada tradición religiosa. La sistematización, desde una metodología dialéctica: praxis-teoría-praxis, lleva a problematizar principalmente la categoría diálogo interreligioso, muy discutible en un contexto de educación intercultural. La aproximación al tema de estudio desde la dimensión religiosa – poco explorada en los estudios interculturales – aporta información valiosa que enriquece la comprensión de la convivencia intercultural. Se concluye lo siguiente: la relevancia de la formación espiritual fecundada por las dos tradiciones religiosas, la importancia de los símbolos en la construcción de la identidad y la identificación de tres tipologías del estudiantado que correlaciona la formación de la identidad religiosa y su apertura al diálogo interreligioso.

[1] Para evitar confusión en la expresión plural de la palabra mapuche, se utilizará mapuches, pero en rigor las palabras en mapudungun no debieran pluralizarse con “s”, sino anteponer la partícula “pu”, que es un pluralizador de sustantivos.