bluuebunny/crossref_metadata_2025_split huggingface dataset:
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Published: January 2025

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Association between ACE (I/D) polymorphism and physical performance
in Brazilian handballers
Authors: Silvino Valmir Oliveira , Almeida Sandro Soares , Apaza Helen Matias , de Moura Rayane Carvalho , Costa Crislane de Moura , Ferreira Cirley Pinheiro , Beleense George Sales , Ribeiro Sérgio Luís Galan , dos Santos Marcos Antonio Pereira 
Published: January 2025

AbstractThis study investigated the association between the ACE (I/D) polymorphism and
strength phenotypes in Brazilian male handball players, considering their
playing position. A total of 105 male junior handball players and 92 controls
were evaluated. The ACE I/D polymorphism was genotyped by conventional PCR
followed by electrophoresis in agarose gel. All participants were
anthropometrically evaluated and performed the standing long jump (SLJ) and
medicine ball throw (MBT) tests. Athletes presented superior performance in the
SLJ and MBT tests compared to the control group in all playing positions
(p<0.01). No significant differences were observed in genotype or allele
frequencies when comparing athletes and controls or among playing positions.
However, a significant difference was observed when comparing all athletes to
controls using the over-dominant model (II+DD vs. ID; p=0.035). Additionally, ID
athletes had better performance in the MBT than DD players (p=0.04), athletes
with II+ID and II+DD genotypes exhibited superior performance in the SLJ test
(p<0.04), and ID athletes demonstrated increased height compared to II+DD
counterparts (p=0.01). In conclusion, our data showed a potential association
between ACE (I/D) polymorphism and overall athletic predisposition in handball
players, with no association with playing position.
Therapeutic Drug Monitoring of Cariprazine – Updated Values for a
Dose-Related Reference Range
Authors: Sattaf Fabian , Scherf-Clavel Maike , Unterecker Stefan , Eckert Andreas , Reif Andreas , Hahn Martina 
Published: January 2025

AbstractDose-related reference ranges can be used in therapeutic drug monitoring to
monitor pharmacotherapy. The deviation of a measured serum concentration
from the expected serum concentration at the corresponding dose can thus be
identified early and responded to appropriately. The serum concentrations of
patients treated with cariprazine regularly deviated from this dose-related
reference range. As this is a relatively new drug with only one
recommendation on values for a dose-related reference range, the values were
tested for validity using real-world data.Serum concentrations of 24 patients receiving cariprazine once daily were
analyzed retrospectively. Only patients without pharmacokinetic
abnormalities were included. The measured serum concentrations were compared
with the values of the dose-related reference range in the guidelines of the
Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie
consensus guidelines of 2017 and checked whether a sufficient number of
serum concentrations were within the dose-related reference range.Only 45.8% of the measured serum concentrations were within the dose-related
reference range. The C/D ratio was 1.58±0.73. Accordingly, a lower value of
0.85 and an upper value of 2.31 were calculated for the updated dose-related
reference range, which is below the currently recommended values.The results suggest that the current values for the dose-related reference
range are too high and require adjustment. The updated dose-related
reference range lies between 0.85 and 2.31, with a mean of 1.58±0.73.
Diagnostischer Nutzen des MTA-Scores in Abhängigkeit von Patientenalter und zerebraler Mikroangiopathie sowie in Zeiten automatisierter Analyseverfahren
Authors: Sander Pauline Klara , Sauer Cathrin , Grey Arne , Krukowski Pawel , Linn Jennifer , Brandt Moritz D. , Haussmann Robert 
Published: January 2025

Zusammenfassung  Analyse des diagnostischen Nutzens des MTA-Scores im Kontext von Patientenalter, zerebraler Mikroangiopathie und automatisierten Analyseverfahren.  retrospektive Analyse von Patienten mit subjektiver kognitiver Störung (SCD), amnestischem MCI (aMCI), Alzheimer-Demenz (AD) und gemischter Demenz (MD) aus einem universitären Demenzzentrum, die sich von 02/2016 bis 12/2020 erstmals zur Demenzdiagnostik inklusive einer kraniellen MRT vorgestellt hatten. Eingeschlossen wurden Patienten, bei denen eine 3D-T1-Sequenz und eine FLAIR-Sequenz für die automatisierte Hirnvolumetrie und Läsionsdetektion- und -volumetrie mittels einer CE-zertifizierten Software zur Verfügung stand. Es erfolgte die Erhebung des MTA-Scores, des Fazekas-Scores, der automatisiert-volumetrisch erfassten Hippocampus- und Temporallappen-Perzentilen sowie des Gesamtläsionsvolumens der weißen Substanz.  Im Beobachtungszeitraum von 02/2018 bis 12/2020 wurden 242 Patienten (100 männlich, 142 weiblich, Durchschnittsalter 74,7±9,9 Jahre) mit SCD (n=20), aMCI (n=110), AD (n=62) und MD (n=50) analysiert. Der MTA-Score korrelierte stark mit dem Patientenalter (ρ=0,545; p<0,001), was insbesondere in der aMCI- und der AD-Gruppe beobachtbar war. Dabei unterschied sich der MTA-Score ausschließlich zwischen Prodromal- und Demenzstadien signifikant (aMCI vs. AD: p=0,005), während die Hippocampus-Perzentilen auch tendenzielle Unterschiede zwischen SCD und aMCI detektierten. MTA-Score und Hippocampus-Perzentilen korrelierten insgesamt signifikant (ρ=−0,385; p<0,001), was in den Einzelgruppen nur bei aMCI- und AD-Patienten nachweisbar war. Der MTA-Score und auch die Hippocampus-Perzentilen korrelierten mit den Temporallappen-Perzentilen. Insgesamt korrelierten MTA- und Fazekas-Score mittelstark miteinander (ρ=0,451; p<0,001), in der Auswertung der einzelnen Patientengruppen nur in der aMCI- und der AD-Gruppe. Korrelationen zwischen Hippocampus-Perzentilen und Gesamtläsionsvolumina der weißen Substanz wurden weder insgesamt, noch innerhalb der diagnostischen Gruppen beobachtet.  Bei der Interpretation des MTA-Scores muss das Patientenalter in Form alterskorrigierter Referenzwerte berücksichtigt werden. Insbesondere in der Frühdiagnostik zeigen automatisierte volumetrische Verfahren möglicherweise Vorteile in der Diagnostik subjektiver und leichter kognitiver Störungen, wobei der MTA-Score gute Korrelationen mit volumetrisch erfassten Hippocampus-Perzentilen zeigt. Ob die hippocampale Atrophie durch vaskulär bedingte Denervierungsprozesse im Rahmen einer zerebralen Mikroangiopathie moduliert wird, bedarf weiterer Untersuchungen.
Visible-Light-Induced Enantioselective Dearomative [2+2]-Cycloaddition/Ring-Expansion Sequence of Indoles with Simple Alkenes
Authors: Liu Xiaohua , Cao Weidi , Feng Xiaoming , Hou Liuzhen , Yang Longqing 
Published: January 2025

AbstractCatalytic asymmetric dearomatization reactions represent a versatile platform for constructing complex optically active three-dimensional molecules. We present a visible-light-induced asymmetric dearomative [2+2] cycloaddition/ring-expansion reaction of indole derivatives with simple alkenes in the presence of a chiral N,N′-dioxide/terbium complex. This strategy provides access to a range of valuable cyclopenta[b]indoles, and its synthetic potential is further showcased through a gram-scale synthesis, potential bioactivity against human breast cancer, and further transformation into a yuehchukene analogue. A series of control and spectral experiments, as well as DFT calculations, provide compelling evidence to elucidate the reaction mechanism.
Optimizing Care and Maintenance of Enteric Tubes: Insights into Percutaneous Radiologically Placed Gastrointestinal Luminal Tubes
Authors: Khavandi Mohammad Mahdi , Nezami Nariman , Huang Steven Y. , Tam Alda L. , Odisio Bruno C. , Mahvash Armeen , Abdelsalam Mohamed E. , Kuban Joshua D. , Sheth Rahul A. , Habibollahi Peiman 
Published: January 2025

AbstractPercutaneous enteric tubes, including gastrostomy, gastrojejunostomy, and percutaneous transesophageal gastrostomy, are essential for patients who cannot maintain adequate oral nutrition or require gastric decompression due to conditions like malignant bowel obstruction. Proper care and maintenance are crucial to prevent complications and maintain function. Enteric tubes are inserted using various techniques at different locations based on patient needs and anatomical considerations. Enteric tubes play a vital role in patient care, and continued research and innovation are necessary to improve outcomes and reduce complications. Routine care involves regular flushing and site maintenance to prevent occlusion and infection. While complications are common, they can be effectively managed or avoided with proper care. This review outlines the care, maintenance protocols, and post-placement complication management for enteric tubes.
Important Anatomy in Lymphatic Interventions: A Practical Review
Authors: Crawford Daniel A. , Patel Indravadan J. , Naidu Sailendra G. , Wallace Alex , Ozen Merve , Alzubaidi Sadeer 
Published: January 2025

AbstractNew understanding of the lymphatic system as well as increasing recognition of its importance in various pathologies have increased the opportunity to perform lymphatic interventions. Advancement in our understanding of the lymphatic system anatomy, including variations, combined with improved imaging has renewed interest in both surgical and interventional management of a wide range of complex lymphatic pathologies. It is important for the proceduralist to recognize the anatomy, variability, and physiology of the lymphatic system, including lower extremity lymphatic drainage, cisterna chyli location, and thoracic duct drainage. The purpose of this study is to convey the practical aspects of performing lymphatic interventions in an effort to improve the speed and reliability of these procedures.
Heterogeneous integration of amorphous silicon carbide on thin film lithium niobate
Authors: Li Zizheng , Sharma Naresh , Lopez-Rodriguez Bruno , van der Kolk Roald , Scholte Thomas , Voncken Hugo , van der Boom Jasper , Gröblacher Simon , Zadeh Iman Esmaeil 
Published: January 2025

In the past decade, lithium niobate (LiNbO3 or LN) photonics, thanks to its heat-free and fast electro-optical modulation, second-order non-linearities, and low-loss, has been extensively investigated. Despite numerous demonstrations of high-performance LN photonics, processing lithium niobate remains challenging and suffers from incompatibilities with standard complementary metal–oxide–semiconductor (CMOS) fabrication lines, limiting its scalability. Silicon carbide (SiC) is an emerging material platform with a high refractive index, a large non-linear Kerr coefficient, and a promising candidate for heterogeneous integration with LN photonics. Current approaches of SiC/LN integration require transfer-bonding techniques, which are time-consuming, expensive, and lack precision in layer thickness. Here, we show that amorphous silicon carbide (a-SiC), deposited using inductively coupled plasma enhanced chemical vapor deposition at low temperatures (&lt;165 °C), can be conveniently integrated with LiNbO3 and processed to form high-performance photonics. Most importantly, the fabrication only involves a standard, silicon-compatible, reactive ion etching step and leaves the LiNbO3 intact, hence its compatibility with standard foundry processes. As a proof-of-principle, we fabricated waveguides and ring resonators on the developed a-SiC/LN platform and achieved intrinsic quality factors higher than 1.06 × 105 and a resonance electro-optic tunability of 3.4 pm/V with a 3 mm tuning length. We showcase the possibility of dense integration by fabricating and testing ring resonators with a 40 μm radius without a noticeable loss penalty. Our platform offers a CMOS-compatible and scalable approach for the implementation of future fast electro-optic modulators and reconfigurable photonic circuits, as well as nonlinear processes that can benefit from involving both second- and third-order nonlinearities.
The gonorrhoea care cascade in general practice: a descriptive study to explore gonorrhoea management utilising electronic medical records
Authors: Jung J. , Goller J. L. , Chondros P. , Ong J. , Biezen R. , Pires D. , Capurro D. , Faux N. , Manski-Nankervis J. A. 
Published: January 2025

Background Gonorrhoea notification rates in Australia have more than doubled between 2014 and 2019. We explored gonorrhoea testing patterns and management of gonorrhoea infection in general practice. Methods We analysed de-identified electronic medical record data for individuals who attended 73 Australian general practices (72 in the state of Victoria) between January 2018 and December 2020. The ‘care cascade’ model was utilised to explore gonorrhoea detection and management. Descriptive analysis and logistic regression were used to investigate factors associated with gonorrhoea testing, treatment and retesting. Results During the study period, there were a total of 1,027,337 clinical episodes. Of these, 5.6% (n = 57,847, 95% confidence interval [CI] 4.5–6.7) involved a gonorrhoea test and 1.1% (n = 637, 95% CI 0.8–1.4) tested positive. Of the 637 gonorrhoea cases, 48.4% (n = 308, 95% CI 29.8–67.0) had an Australian guideline-recommended dual antibiotic prescription (ceftriaxone and azithromycin) recorded. Of 329 cases without a dual antibiotic prescription, 84.2% (n = 277, 95% CI 77.5–90.9) had reattended the clinic. Among the 206 gonorrhoea cases with dual antibiotic prescription recorded in 2018 and 2019, 32.0% (n = 66, 95% CI 25.3–38.8) were retested from 6 weeks to 6 months post-treatment. Of the 140 gonorrhoea cases that were not retested, 54.3% (n = 76, 95% CI 46.8–61.8) reattended the clinic within 6 months of treatment. Conclusion The low proportion of gonorrhoea cases prescribed recommended antibiotics and retested within recommended timeframes suggests opportunities for integrating Australian STI guidelines into primary care. Further exploration of care pathways is warranted to determine if care was provided but not recorded, provided elsewhere or not provided.
Measuring Pain in Insects
Authors: Gibbons Matilda 
Published: January 2025

Abstract
Pain is an aversive subjective experience that is consciously experienced as unpleasant. Causing unnecessary pain to animals is ethically wrong because pain is intrinsically aversive. Trillions of insects are used, harmed and killed per year, but they are excluded from animal welfare legislation because they have not yet been tested for their capacity for pain. Therefore, the evaluation of whether insects can feel pain is a necessity. This case describes potential ways to measure pain in an animal for which there is currently little or no published research about which behaviours might indicate pain.

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Exploring the moiré effect of graphene structure through optical diffraction experiments
Authors: Fei Ying , Liu Ruiyang , Zhou Yiquan , Gao Yingying , Tang Binxuan , Zheng Yuan 
Published: January 2025

Abstract
Moiré effect is a common phenomenon that arises from a slight mismatch in the period of two structures. A prominent example in the microscopic world is magic-angle twisted bilayer graphene (MATBG). In this work, to enhance undergraduate students’ advanced learning of interference and diffraction, we reproduced the microscopic structure of MATBG on a macroscopic scale by creating hexagonal structured masks. By designing a suitable optical path, we were able to realize the optical diffraction of this macrostructure. The results revealed two additional periodic diffraction patterns in the twisted double-layer masks, which are relevant to the moiré effect. Through theoretical derivation and computer simulation, we explained the observed diffraction patterns, which matched well with the experiments. This designed project not only improves students’ knowledge in optics and laboratory operation skills, but also deepens their comprehension of moiré effect and crystal diffraction, showcasing its potential for further expansion and application in undergraduate physics education.
Revisiting the Laplace transform in quantum mechanics: correcting a flawed approach for the stationary Schrödinger equation
Authors: Báez Luis M , Santos Andrés 
Published: January 2025

Abstract
The Laplace transform is a valuable tool in physics, particularly in solving differential equations with initial or boundary conditions. A 2014 study by Tsaur and Wang (2014 Eur. J. Phys.
35 015006) introduced a Laplace-transform-based method to solve the stationary Schrödinger equation for various potentials. However, their approach contains critical methodological flaws: the authors disregard essential boundary conditions and apply the residue theorem incorrectly in the inverse transformation process. These errors ultimately cancel out, leading to correct results despite a flawed derivation. In this paper, we revisit the use of the Laplace transform for the one-dimensional Schrödinger equation, clarifying correct practices in handling boundary conditions and singularities. This analysis offers a sound and consistent framework for the application of Laplace transforms in stationary quantum mechanics, underscoring their educational utility in quantum mechanics coursework.
Single photon emitters in van der Waals solids for quantum photonics: materials, theory and molecular-scale characterization probes
Authors: Kaul Anupama B , Wang Yuanxi , Li An-Ping , Li Xinxin , Ma Xuedan 
Published: January 2025

Abstract
Strong light–matter interactions in two-dimensional layered materials (2D materials) have attracted the interest of researchers from interdisciplinary fields for more than a decade now. A unique phenomenon in some 2D materials is their large exciton binding energies (BEs), increasing the likelihood of exciton survival at room temperature. It is this large BE that mediates the intense light–matter interactions of many of the 2D materials, particularly in their monolayer limit, where the interplay of excitonic phenomena poses a wealth of opportunities for high-performance optoelectronics and quantum photonics. Within quantum photonics, quantum information science (QIS) is growing rapidly, where photons are a promising platform for information processing due to their low-noise properties, excellent modal control, and long-distance propagation. A central element for QIS applications is a single photon emitter (SPE) source, where an ideal on-demand SPE emits exactly one photon at a time into a given spatiotemporal mode. Recently, 2D materials have shown practical appeal for QIS which is directly driven from their unique layered crystalline structure. This structural attribute of 2D materials facilitates their integration with optical elements more easily than the SPEs in conventional three-dimensional solid state materials, such as diamond and SiC. In this review article, we will discuss recent advances made with 2D materials towards their use as quantum emitters, where the SPE emission properties maybe modulated deterministically. The use of unique scanning tunneling microscopy tools for the in-situ generation and characterization of defects is presented, along with theoretical first-principles frameworks and machine learning approaches to model the structure-property relationship of exciton–defect interactions within the lattice towards SPEs. Given the rapid progress made in this area, the SPEs in 2D materials are emerging as promising sources of nonclassical light emitters, well-poised to advance quantum photonics in the future.
Transition metal-doped ZrS2 monolayer as potential gas sensor for CO2, SO2, and NO2: density functional theory and non-equilibrium Green’s functions’ analysis
Authors: Zhu Min-Qi , Wang Xue-Feng , Vasilopoulos P 
Published: January 2025

Abstract
Density functional theory combined with the non-equilibrium Green’s function (NEGF) is used to systematically analyze the adsorption and sensing properties of a pristine ZrS2 monolayer doped with transition metals (TMs) Ni, Pd, or Pt, for three target gases CO2, SO2, and NO2. Our findings reveal that the pristine ZrS2 monolayer exhibits only a weak physical adsorption, whereas TM-doped monolayers show significantly enhanced sensing capabilities. The Ni–ZrS2 monolayer increases the charge transfer for NO2 by a factor of 6.75, while the Pd–ZrS2 monolayer shows an eightfold improvement for SO2. Notably, the adsorption of NO2 leads to substantial modifications in the band structure of the ZrS2 monolayer, suggesting its use as a resistive NO2 sensor. The Pd–ZrS2 and Pt–ZrS2 monolayers exhibit shorter recovery times at temperatures of 348 K and 398 K after adsorbing SO2 and NO2, highlighting their suitability for repeated detection. Additionally, the transport properties of TM-ZrS2-based devices are analyzed by NEGF. For CO2, SO2, and NO2, sensitivities of up to 1.53, 4.60, and 2.01 are observed for the Pd–ZrS2, Pt–ZrS2, and Ni–ZrS2-based devices, respectively, under specific bias. This study demonstrates that TM-ZrS2-based devices can realize repetitive and sensitive detection of specific target gases at different temperatures and biases, revealing their potential applications.
High-field electron transport and current saturation mechanism of open region channel in submicron split-gate AlGaN/GaN HFETs
Authors: Zhou Heng , Zhama Tuofu , Wang Mingyan , Lin Zhaojun , Zeng Yuping , Cui Peng 
Published: January 2025

Abstract
Electron transport was studied at low and high electric fields, alongside current saturation mechanisms, within the open region channel of submicron split-gate AlGaN/GaN heterostructure field-effect transistors (SG HFETs). By calculating the low-field electron mobility, it is found that the gate voltage-dependent polarization Coulomb field (PCF) scattering played a dominant role in the various scattering mechanisms. A coupled Technology Computer Aided Design (TCAD) and Monte Carlo (MC) simulation method was adopted in the analysis of the high-field electron transport. When the gate–source voltage is −4 V and the drain–source voltage is 10 V, the momentum relaxation effect caused by PCF scattering reduces the peak electron velocity in the open region channel from 3 × 107 cm s−1 to 1.2 × 107 cm s−1. The presence of the virtual gate effect in the TCAD leads to a decrease in electron density within the open region channel, creating a localized high-resistance region and consequently a local high electric field. In this high-field region, electrons attain their saturation drift velocity, resulting in current saturation. Combining the virtual gate effect and the velocity-field relationship obtained by MC simulation, the simulation results of the output characteristics at V
GS ⩽ −4 V are in good agreement with the experimental results. This work extends the analysis of electron transport and PCF scattering theory in SG HFETs from low-field conditions to high-field conditions. The effect of the virtual gate effect on the channel current saturation in the open region is quantitatively revealed.