bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sugars induced exfoliation of porous graphitic carbon nitride for efficient hydrogen evolution in photocatalytic water-splitting reaction
Authors: Baranowska Daria , Zielinkiewicz Klaudia , Mijowska Ewa , Zielinska Beata 
Published: October 2023

Abstract

Photocatalytic hydrogen evolution holds great promise for addressing critical energy and environmental challenges, making it an important area in scientific research. One of the most popular photocatalysts is graphitic carbon nitride (gCN), which has emerged as a noteworthy candidate for hydrogen generation through water splitting. However, ongoing research aims to enhance its properties for practical applications. Herein, we introduce a green approach for the fabrication of porous few-layered gCN with surface oxygen doping and nitrogen defects with promoted performance in the hydrogen evolution reaction. The fabrication process involves a one-step solvothermal treatment of bulk graphitic carbon nitride (bulk-gCN) in the presence of different sugars (glucose, sucrose, and fructose). Interestingly, the conducted time-dependent process revealed that porous gCN exfoliated in the presence of fructose at 180 ℃ for 6 hours (fructose_6h) exhibits a remarkable 13-fold promotion of photocatalytic hydrogen evolution compared to bulk-gCN. The studied materials were extensively characterized by microscopic and spectroscopic techniques, allowing us to propose a reaction mechanism for hydrogen evolution during water-splitting over fructose_6h. Furthermore, the study highlights the potential of employing a facile and environmentally friendly fructose-assisted solvothermal process to improve the efficiency and stability of catalysts based on gCN.
Functional investigation and two-sample Mendelian randomization study of bladder cancer-related genes: focus on gender differences
Authors: He Chenglong , Zhong Siquan , Qin Yan , Jiang Xiaomei , Lyu Yanhua , Xiao Jianjun , Dong Wenjing 
Published: October 2023

Abstract
Objective
Bladder cancer is a common malignant tumor. There is a significant gender difference in the incidence rate, and the pathogenesis has not yet been clarified. The objective of this study was to explore the potential pathogenic genes of bladder cancer, measure the expression of these genes in patients of different sexes, and apply these genes to predict the risk of bladder cancer in clinical practice.
Methods
Genes related to the pathogenesis of bladder cancer were obtained by differential expression analysis and weighted gene co-expression network analysis (WGCNA). Key genes were obtained by intersection. Then, we analyzed the biological functions of key genes through KEGG and GO and constructed a PPI network to screen hub genes and generate a nomograph model to predict the risk of bladder cancer. The correlation between VEGFA and immune cell infiltration in bladder cancer was evaluated by immunocyte infiltration analysis. Finally, a two-sample Mendelian randomization study was conducted to determine the causal effect of VEGFA on bladder cancer.
Results
We obtained 376 key genes in the male bladder cancer group and 328 key genes in the female bladder cancer group. GO and KEGG analyses showed differences in the biological functions of these genes between male and female patients. Using the expression profile of the hub genes (CAV1, VEGFA, COL3A1, MYL9, and COL1A2 in males and COL3A1, ACTA2, TPM2 TPM1, and COL1A2 in females), we constructed a nomogram model to predict the risk of bladder cancer for males and females, respectively. In addition, the ROC curve showed that the model is effective in predicting bladder cancer. Besides, we found that there was a significant correlation between the expression of VEGFA and immune cell infiltration in male bladder cancer, but not in female patients. Finally, the Mendelian randomized study showed that there was a causal relationship between VEGFA and bladder cancer risk.
Conclusion
There are gender differences in the expression level and biological function of bladder cancer-related genes. We found that VEGFA has a causal relationship with the risk of bladder cancer, which may provide new insights into the diagnosis and treatment of bladder cancer.
Decolonising environmental risk assessments of Potentially Polluting Wrecks: A case study of the wreck of the USS Mississinewa in Ulithi Lagoon, Federated States of Micronesia
Authors: Hill Polly Georgiana , Rodway-Dyer Sue 
Published: October 2023

Abstract
Millions of tonnes of oil lie entombed within wrecks from two world wars which, when released, can cause environmental devastation. Wrecks are predominantly risk assessed by the Global North Nations responsible, resulting in an epistemology that separates human from nature. This research aimed to decolonise risk assessments to capture the spatially heterogeneous nature of human vulnerability to oil pollution. Triangulation analysis of interviews and official reports relating to the USS Mississinewa oil spill identified three Global South issues a Eurocentric risk assessment failed to capture: region-specific meteorological conditions causing the leak, remoteness making external resources slow to arrive, and the impact of the fishery closure on traditional subsistence lifestyles. A vulnerability assessment is proposed to prioritise wrecks in susceptible locations. Recommendations are made for a collaborative approach to wreck management by including local voices, resisting the Global North assumption of generality, and recognising the priorities of those living with wrecks.
Understanding of electronic, structural and optical properties of transition metal doped C 20 nano-cage
Authors: Ghiasi Reza , Daneshdoost Vahid , Tale Rose 
Published: October 2023

Abstract
In the present research, computational perspective of doping of C20 nano-cage with Co3+, Ni2+, Cu+ and Zn cations was reported at B3LYP*/6-311g(d,p) level of theory in singlet state. Vibrational analysis was confirmed placing of the optimized cluster of the minimum potential energy curve. M-C bond distances, molecular orbital analysis and electronic spatial extent (ESE) values of the clusters were computed. Photoelectron spectrum (PES) of these clusters were provided. Aromaticity of the studied clusters were compared with NICS values. Doping effect on the polarity, polarizability and hyperpolarizability of the cluster was illustrated.
Robust inference and errors in studies of wildlife control
Authors: Treves Adrian , Khorozyan Igor 
Published: October 2023

Abstract

Randomized, controlled trials (RCT) are seen as the strongest basis for causal inference, but their strengths of inference and error rates relative to other study have never been quantified in wildlife control and rarely in other ecological fields. We simulate common study designs from simple correlation to RCT with crossover design. We report rates of false positive, false negative, and over-estimation of treatment effects for five common study designs under various confounding interactions and effect sizes. We find non-randomized study designs mostly unreliable and that randomized designs with suitable safeguards against biases have much lower error rates. One implication is that virtually all studies of lethal predator control interventions appear unreliable. Generally, applied fields can benefit from more robust designs against the common confounding effects we simulated.
Decreasing trend in lean body mass in young Japanese adult women associated with their birth weight
Authors: Hisatsune Manami , Hakoda Masayuki 
Published: October 2023

Abstract
Despite a 30-year decline in birth weight since 1976 in Japan, the health effects of this decline after a period of growth remain unclear. Lean body mass (LBM) at age 20–21 years was measured annually for 14 years in women with birth years from 1987 to 2001, a period in which a notable birth weight decline was observed in Japan. The birth weight of the participants was obtained from data recorded in the original Japanese Maternal and Child Health Handbook. The participants’ birth weight and the LBM at age 20–21 years significantly decreased during the 14 years of examination; however, fat mass did not decrease during this period. The participants’ LBM significantly correlated with their birth weight. These results suggest that the trend in declining birth weight is manifested as a trend in declining LBM 20 years later. Because low LBM is a risk factor for the development of lifestyle-related diseases such as type 2 diabetes and atherosclerosis, a future increase in these diseases among Japanese women may be anticipated.
Organic fertilizers and Bacillus spp increasing NPK uptake and resistance to stunting deseases of Superior and local cultivars of organic rice in Imogiri, Bantul, Indonesia
Authors: Romdhoni Ahmad Harish , utami Sri Nuryani Hidayah , Prasetya Angga , Sulandari Sri 
Published: October 2023

Abstract
The research aimed to determine the effects of the doses of organic fertilizer and the addition of Bacillus spp. on the changes in soil chemical properties, NPK nutrient uptake, vegetative and generative growth, and resistance to stunting as well as yields of superior and local cultivars of organic rice. Soil samples were taken before and after one week of treatments. Meanwhile, observation of plant samples was carried out from seven days after planting until harvest, then these samples were taken at the end of the vegetative and generative growth stage. This research was conducted in Kebonagung, Imogiri, Bantul from October 2020 to May 2021. The treatments consisted of the application of organic fertilizer at doses of 0 tons/ha, 5 tons/ha, and 10 tons/ha and the addition of Bacillus spp. on the superior and local cultivars of organic rice. The results suggested that the treatment of 10 tons/ha fertilizer combined with Bacillus spp. affect the organic C, CEC, and availability of soil NPK. The treatment also increased the NPK nutrient uptake and improved plant resistance to stunting diseases due to RRSV. Among all the treatments applied, the highest yield of ‘Padjajaran’ (12.13 tons/ha) and ‘Mentik Wangi’ (11.62 tons/ha) cultivar was obtained when treated with 10 tons/ha fertilizer combined with Bacillus spp. and 10 tons/ha fertilizer without Bacillus spp., respectively.
Reliable strategy constructed with polysiloxane to achieve fire resistance, antibacterial properties of cotton fabrics
Authors: Jin Xin , Li Wennan , Yang Chenghao , Li Xu , Liu Xiangji , Ma Jiahui , Zhu Ping , Lu Zhou , Dong Chaohong 
Published: October 2023

Abstract
A phosphorus containing polysiloxane flame retardant and antibacterial agent has been synthesized and applied to cotton fabrics. A treatment method has been implemented to achieve the dual function of flame retardant and antibacterial on cotton fabrics, Achieve two things at one stroke. This flame retardant method can effectively avoid the problem of formaldehyde release from fabrics treated with phosphorus containing flame retardants. Amino silicone oil and p-bromobenzaldehyde are used to synthesize intermediate products, phosphite, 5,5-dimethylhydantoin, and phosphite to obtain halogenated amine precursors (DPTMS). The VFT and LOI results indicate that this additive can effectively improve the flame retardancy of fabrics. Thermogravimetric analysis shows that the residual carbon content of DPTMS/Cotton can reach 9.1% and 24.7% under air and nitrogen conditions, respectively, indicating that DPTMS can effectively improve the thermal stability of cotton fabrics. The cone calorimetry test showed that the total heat release of DPTMS/Cotton was significantly reduced by 49.8% compared to that of Cotton. After being heated, polysiloxane provides a more solid carbon layer, which has a suffocating effect on the flame. The results of antibacterial test are surprising, and the antibacterial rate of DPTMS/Cotton against E. coli and S. aureus can reach more than 99%.
The association between physical activity and depression in cancer patients: A cross-sectional study from NHANES 2007-2018
Authors: Zheng Jiaxue , Zheng Peiqing , Han Yi , Zhang Mingyan , Gu Jianzhong 
Published: October 2023

Abstract
Low-intensity physical activity is associated with increased depressive symptoms in the general population, however, their relationship is still unclear in cancer patients. The primary aim of this study is to explore the relationship between physical activity and depression in cancer patients. 1993 participants aged 20 to 79 years from the 2007–2018 National Health and Nutrition Examination Survey (NHANES) were obtained to participate in this study. All analyzes were performed using EmpowerStats and R software(version 3.4.3), and multivariate logistic regression analyses were conducted. Of the 1993 participants with cancer, 254 (12.70%) reported depression. After adjusting for all confounders, participants with high-intensity physical activity had a 40% lower rate of depression compared to participants with low-intensity physical activity(OR = 0.60[95% CI 0.45, 0.81]). We made further analyses stratified and the results showed that in the fully adjusted model, physical activity had a significant effect on the risk of depression for participants who were female, age < 60 years, non-Hispanic white, educated less than 11th grade, divorced/separated, and former smokers, and the difference was statistically significant (p < 0.05). Physical activity is an independent risk factor for the incidence of depression, and low-intensity physical activity is associated with elevated depressive symptoms in cancer patients.
A Novel Quinoline With Airway Relaxant Effects and Anti-Inflammatory Properties
Authors: Bergwik Jesper , Liu Jielu , Padra Médea , Bhongir Ravi K.V. , Tanner Lloyd , Xiang Yujiao , Lundblad Mia , Egesten Arne , Adner Mikael 
Published: October 2023

Abstract

Background
In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Here, we investigated the relaxant and anti-inflammatory properties in the airways of a novel quinoline (RCD405).
Methods
The airway relaxant effect of RCD405 was examined in isolated airways from humans, dogs, rats and mice. Murine models of ovalbumin (OVA)-induced allergic asthma and LPS-induced airway inflammation were used to study the effects in vivo. Airway responsiveness was determined using methacholine provocation. Immune cell recruitment to bronchi was measured using flow cytometry and histological analyses were applied to investigate immune cell influx and goblet cell hyperplasia of the airways. The inflammatory response, as reflected by the production of cytokines and chemokines, was measured using a multiplex immunoassay. The expression levels of asthma-related genes in murine lung tissue were determined by PCR. The involvement of NF-κB and metabolic activity was measured in the human monocytic cell line THP-1.
Results
RCD405 demonstrated a relaxant effect on carbachol precontracted airways in all four species investigated. The OVA- specific IgE and airway hyperresponsiveness (AHR) were significantly reduced by intratracheal treatment with RCD405. In addition, administration of RCD405 to mice significantly decreased the expression of proinflammatory cytokines and chemokines as well as recruitment of immune cells to the lungs in both OVA- and LPS-induced airway inflammation. In vitro, RCD405 reduced the LPS-induced NF-κB activation and by itself reduced cellular metabolism.
Conclusions
RCD405 has airway relaxant effects and it reduces AHR as well as airway inflammation in the models used, suggesting that it could be a clinically relevant compound to treat inflammatory airway diseases. Possible targets of this compound are complexes of mitochondrial oxidative phosphorylation, resulting in decreased metabolic activity of targeted cells as well as through pathways associated to NF-κB. However, further studies are needed to elucidate the mode of action.
Clinical diagnosis and treatment of 5 cases of TAPCV in infants
Authors: Cheng Weiping , Zhu Junzhao , Xu Youbo , Guo Yingqiang , Shi Lexiang 
Published: October 2023

Abstract
Objective: To explore the clinical diagnosis and treatment methods of supracardiac total anomalous pulmonary venous connection (TAPVC) in infants aged less than 1 year old. Methods: To retrospectively analyse the clinical data of 5 cases of supracardiac TAPCV in infants admitted to Xi'an International Medical Center Hospital from October 2019 to October 2023.
Results: The 5 cases were all infants less than 1 year old, with clinical manifestations of shortness of breath or recurrent pneumonia episodes. The 5 cases were examined by cardiac ultrasonography or CTA after examination by the first physician, and all of them were diagnosed with TAPCV (supra-cardiac type) and arterial ductus arteriosus or ventricular septal defects. The 5 cases underwent a TAPCV correction with a limited period of multidisciplinary consultation (MDT) before surgery, and all made good postoperative recovery.
Conclusion: Parents should be alert to the possibility of congenital heart disease in newborns with shortness of breath, foaming or recurrent pneumonia in infancy. The prognosisof infants with TAPCV is often poor, and the mortality rate is substantially increased due to the untimely diagnosis of preoperative pulmonary venous obstruction (PVO). Precise prenatal examination, professional education on children's prevalent heart diseases, excellent surgical skills and postoperative intensive cardiological care for children are important for making early diagnosis and treatment of supracardiac TAPCV in infants and for improving the postoperative survival rate of children with TAPCV in infants.
The Effect of Combined Training with Quinoa Seed Supplementation on Total Antioxidant Capacity, HbA1c, Lipid Profile and Blood Pressure in Women with Type 2 Diabetes
Authors: Moradi Nilofar , Azizi Mohammad , Niromand Elham , Tahmasebi Worya 
Published: October 2023

Abstract

Background: Type 2 diabetes is a metabolic disorder that often results from unhealthy lifestyle factors such as obesity, physical inactivity, and poor diet. Nonetheless, regular physical activity and proper diet can help manage the disease. In this study, we aimed to evaluate the effectiveness of 8 weeks of combined exercise at home with quinoa seed supplementation on total antioxidant capacity, HbA1c, lipid profile, and blood pressure in women with type 2 diabetes.
Methods: Our study involved 36 women with type 2 diabetes from the Taleghani Diabetes Center in Kermanshah, Iran. We divided the women into three groups, namely: exercise+supplement, supplement, and control, with 12 participants in each group. The exercise+supplement and supplement groups consumed 25 grams of cooked quinoa seeds three times a week and the exercise+supplement group performed combined exercise for 8 weeks, three times a week. We measured blood factors such as TAC, HbA1c, TG, CHOL, HDL, and LDL. We used descriptive statistics to calculate the mean and standard deviation of research data. We used the Kolmogorov-Smirnov Test to evaluate the normality of data distribution. If the data were normal, we used the one-way ANOVA test. We also used t-test to examine within-group differences. We analyzed the data using SPSS software version 26 at a significance level of p <0.05.
Results:Our results showed that the exercise+supplement group had significant differences with the supplement and control groups in TAC, HbA1c, TG, CHOL, HDL, LDL, BMI, weight, and systolic blood pressure (p<0.05). The sup group also had significant differences with the control group in BMI and weight (p<0.05). However, we found no significant difference between the three groups in diastole blood pressure (P>0.05).
Conclusion: In conclusion, based on our study's findings, we can confidently say that 8 weeks of combined training with quinoa supplementation can increase total antioxidant capacity, and reduce HbA1c, lipid profile, BMI, and weight in women with type 2 diabetes.
Trial registration: IRCT20200804048306N1, 13/04/2021 (https://fa.irct.ir)
SLC8A1, a novel prognostic biomarker and immunotherapy target in RSA and UCEC based on scRNA-seq and pan-cancer analysis
Authors: Chu Jijun , Qin Xiujuan , Xu Xian-jin 
Published: October 2023

Abstract
Purpose
As the field of gynecological immunology increasingly focuses on reproduction, the importance of recurrent spontaneous abortion (RSA) is growing. The complex mechanisms underlying the interaction between RSA and cancer are still not well understood. This study seeks to identify a new prognostic biomarker for RSA and cancer.
Methods
Weighted Gene Co-Expression Network Analysis (WGCNA), single-cell RNA sequencing (scRNA-seq), and machine learning algorithms were utilized for the analysis of RSA decidua samples (GSE164449, GSE214607, GSE65099) to identify the hub gene. The expression and distribution of the hub gene were subsequently investigated using the pan-cancer database TCGA. Furthermore, a prognostic prediction was made to assess the hub gene's impact on cancer response, mutation burden, immunity microenvironment, immune checkpoint, and chemotherapy.
Results
SLC8A1 has been identified as a hub gene within the RAS. In pan-cancer analysis, SLC8A1 exhibited strong expression levels in UCEC. The efficacy of SLC8A1 as a predictive marker was substantiated by calibration curves and concordance index. The mutation rate of SLC8A1 was found to be 6% based on the waterfall plot. Immune analysis revealed notable differences in the fractions of T cells and macrophages between the high and low expression groups. The analysis of immune checkpoint has demonstrated notable associations with CD40positive immune checkpoints. Notably, patients classified in the low-risk group exhibited enhanced responsiveness to Osimertinib, Dasatinib, Sepantronium bromid, lbrutinib, and other treatments.
Conclusion
These findings suggest that SLC8A1 may serve as a promising prognostic biomarker and potential target for immunotherapy in the context of RSA and UCEC.
PiPho85, a cyclin dependent kinase of Piriformospora indica rescue colonized maize plants grown under salt stress
Authors: Kashyap Arun Kumar , Kumar Paras , Bakshi Madhunita , Yadav Vikas , Oelmüller Ralf , Dua Meenakshi , Johri Atul Kumar 
Published: October 2023

Abstract
We identified, isolated and functionally characterized, cyclin dependent kinase (CDK), PiPho85 from Piriformospora indica. The identified PiPho85 contains TY, PSTAIRE, protein kinase domain, and an ATP binding site which is highly conserved amongst the Pho85/CDK5 family protein specific for Pho85 of Saccharomyces cerevisiae. In (Δpho85) mutant strain of S. cerevisiae, PiPho85 could regulate the acid phosphatase activity, restore the normal phenotype, provide the salt and drug tolerant capabilities, and found to utilize the non-fermentable sugars. This suggests that PiPho85 complementing the function of Pho85. The knock down (Kd) strain of PiPho85 was generated by RNA interference and named as Kd-PiPho85-P.indica. The Kd strain was found susceptible to salt, drug & osmolarity stress and showed morphological abnormalities like abnormal size hyphae with knot like larger structure. This suggests PiPho85 plays a regularity role in the physiology of P. indica. Further, plants colonized with Kd-PiPho85-P.indica were found to be susceptible to salt stress and showed less growth than that of the plants colonized with the WT P. indica which suggests that PiPho85 plays a crucial role in conferring resistance to colonized plants during salt stress.