bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep phenotyping of socio-emotional skills in children with typical development, neurodevelopmental disorders, and mental health conditions: Evidence from the PEERS
Authors: Anderson Vicki , Darling Simone , Hearps Stephen , Darby David , Dooley Julian , McDonald Skye , Turkstra Lyn , Brown Amy , Greenham Mardee , Crossley Louise , Charalambous George , Beauchamp Miriam H. 
Published: October 2023

Objective
Socio-emotional skills, including social competence and social cognition, form the basis for robust relationships and wellbeing. Despite their importance, these skills are poorly defined and measured, particularly in children with developmental vulnerabilities. As a consequence, targets for effective management and treatment remain unclear. We aimed to i) phenotype social competence and social cognition in typically developing children (TDC) and in children with neurodevelopmental or mental health disorders (clinical groups) and ii) establish the relationships between these child-direct measures and parent ratings of social competence and behavior.

Method
Using a multi-site, cross-sectional study design, we recruited 513 TDC and 136 children with neurodevelopmental (autism spectrum disorder [ASD], attention deficit hyperactivity disorder [ADHD]) or mental health (Anxiety Disorder [ANX]) diagnoses (age range 5–15 years). We administered the Paediatric Evaluation of Emotions, Relationships and Socialisation (PEERS) to children, and parents completed standardised questionnaires rating children’s socio-emotional function.

Results
Standardised parent questionnaires revealed a global pattern of everyday socio-emotional impairment that was common to all clinical groups, while PEERS identified disorder-specific socio-cognitive profiles for children with ASD, ADHD and ANX. Compared to TDCs, children with ASD demonstrated global socio-cognitive impairment. Children with ADHD were impulsive, demonstrating difficulties managing speed accuracy trade-offs. Children with ANX exhibited slowed social decision-making, but otherwise intact skills.

Conclusions
Standardized parent questionnaires of child socio-emotional function reveal differences between children with typical and atypical development, but do not yield disorder-specific, socio-emotional profiles. In contrast, findings from the PEERS objective assessment suggest that that ASD, ADHD and ANX are associated with distinct socio-cognitive phenotypes, to more accurately guide and target management and treatment of impaired social competence.
Time course of western diet (WD) induced nonalcoholic steatohepatitis (NASH) in female and male Ldlr-/- mice
Authors: Spooner Melinda H. , Garcia-Jaramillo Manuel , Apperson K. Denise , Löhr Christiane V. , Jump Donald B. 
Published: October 2023

Background
Nonalcoholic fatty liver disease (NAFLD) is a global health problem. Identification of factors contributing to the onset and progression of NAFLD have the potential to direct novel strategies to combat NAFLD.

Methods
We examined the time course of western diet (WD)-induced NAFLD and its progression to nonalcoholic steatohepatitis (NASH) in age-matched female and male Ldlr-/- mice, with time-points at 1, 4, 8, 20 and 40 weeks on the WD. Controls included Ldlr-/- mice maintained on a purified low-fat diet (LFD) for 1 and 40 weeks. The approach included quantitation of anthropometric, plasma and liver markers of disease, plus hepatic histology, lipids, oxylipins, gene expression and selected metabolites.

Results
One week of feeding the WD caused a significant reduction in hepatic essential fatty acids (EFAs: 18:2, ω6, 18:3, ω3) which preceded the decline in many C20-22 ω3 and ω6 polyunsaturated fatty acids (PUFA) and PUFA-derived oxylipins after 4 weeks on the WD. In addition, expression of hepatic inflammation markers (CD40, CD44, Mcp1, Nlrp3, TLR2, TLR4, Trem2) increased significantly in both female & male mice after one week on the WD. These markers continued to increase over the 40-week WD feeding study. WD effects on hepatic EFA and inflammation preceded all significant WD-induced changes in body weight, insulin resistance (HOMA-IR), oxidative stress status (GSH/GSSG ratio) and histological and gene expression markers of macrosteatosis, extracellular matrix remodeling and fibrosis.

Conclusions
Our findings establish that feeding Ldlr-/- mice the WD rapidly lowered hepatic EFAs and induced key inflammatory markers linked to NASH. Since EFAs have an established role in inflammation and hepatic inflammation plays a major role in NASH, we suggest that early clinical assessment of EFA status and correcting EFA deficiencies may be useful in reducing NASH severity.
Feasibility and usability of a virtual-reality-based sensorimotor activation apparatus for carpal tunnel syndrome patients
Authors: Lakshminarayanan Kishor , Shah Rakshit , Daulat Sohail R. , Moodley Viashen , Yao Yifei , Ezhil Srignana Lokesh , Ramu Vadivelan , Sengupta Puja , Madathil Deepa 
Published: October 2023

Purpose
This study aimed to assess the usability of a virtual reality-assisted sensorimotor activation (VRSMA) apparatus for individual digit rehabilitation. The study had two main objectives: Firstly, to collect preliminary data on the expectations and preferences of patients with carpal tunnel syndrome (CTS) regarding virtual reality (VR) and an apparatus-assisted therapy for their affected digits. Secondly, to evaluate the usability of the VRSMA apparatus that was developed.

Methods
The VRSMA system consists of an apparatus that provides sensory and motor stimulation via a vibratory motor and pressure sensor attached to a button, and a virtual reality-based visual cue provided by texts overlaid on top of a 3D model of a hand. The study involved 10 CTS patients who completed five blocks of VRSMA with their affected hand, with each block corresponding to the five digits. The patients were asked to complete a user expectations questionnaire before experiencing the VRSMA, and a user evaluation questionnaire after completing the VRSMA. Expectations for VRSMA were obtained from the questionnaire results using a House of Quality (HoQ) analysis.

Results
In the survey for expectations, participants rated certain attributes as important for a rehabilitation device for CTS, with mean ratings above 4 for attributes such as ease of use, ease of understanding, motivation, and improvement of hand function based on clinical evidence. The level of immersion and an interesting rehabilitation regime received lower ratings, with mean ratings above 3.5. The survey evaluating VRSMA showed that the current prototype was overall satisfactory with a mean rating of 3.9 out of 5. Based on the HoQ matrix, the highest priority for development of the VRSMA was to enhance device comfort and usage time. This was followed by the need to perform more clinical studies to provide evidence of the efficacy of the VRSMA. Other technical characteristics, such as VRSMA content and device reliability, had lower priority scores.

Conclusion
The current study presents a potential for an individual digit sensorimotor rehabilitation device that is well-liked by CTS patients.
A Clinicopathologic Continuum of Eosinophilic Gastrointestinal Diseases in an Adult With Tuberculosis and Latent Hepatitis B Virus Infection
Authors: Nguyen Phong V. , Quach Duc T. , Bui Minh H.Q. , Dang Thinh P. , Talley Nicholas J. 
Published: October 2023

ABSTRACT
Eosinophilic gastroenteritis (EGE) is considered distinct from eosinophilic colitis (EC). A 59-year-old man presented with a colonic tumor, who had resolution of pain and diarrhea after surgery, then 7 months later developed proton-pump inhibitor-responsive dysphagia with esophagitis, and 9 months later presented again with pain and diarrhea where EGE with concurrent eosinophilic esophagitis was diagnosed. Review of the resected tumor specimen identified EC with an adenoma. Workup revealed tuberculosis and latent hepatitis B virus requiring treatment before commencing immunosuppressive therapy plus a 6-food elimination diet that led to complete resolution within 3 weeks. EC may precede EGE and eosinophilic esophagitis.
Periodic verification of results’ comparability between several analyzers: experience in the application of the EP31-A-IR guideline
Authors: Guiñón Leonor , Illana Francisco J. , Cuevas Biel , Canyelles Marina , Martínez-Bru Cecília , García-Osuna Álvaro 
Published: October 2023

Abstract

Objectives
To assess the usefulness of the EP31-A-IR guideline published by the Clinical and Laboratory Standards Institute (CLSI) to perform the periodic verification of results’ comparability between several analyzers.

Methods
Twenty-four biochemistry parameters that could be measured in different analyzers were included: albumin, alkaline phosphatase, alanine aminotransferase, amylase, aspartate aminotransferase, calcium, chloride, C-reactive protein, creatine kinase, creatinine, direct bilirubin, gamma glutamyl transferase, glucose, lactate dehydrogenase, magnesium, phosphate, potassium, sodium, total bilirubin, total cholesterol, total protein, triglycerides, urea and uric acid. In accordance with the EP31-A-IR guideline: (1) Patient samples were selected considering the concentration or activity of interest. (2) Acceptance criteria were established specifically for each concentration or activity level. A quality specification based on biological variation or on state of the art was selected, considering the analytical performance of the available technology. (3) Maximum allowable differences (MAD) between analyzers were calculated. (4) Measurements were performed as stated in appendix B of the guideline. (5) Maximum differences between analyzers were calculated. Results were considered comparable when the maximum difference was less than or equal to the MAD.

Results
For the 24 parameters evaluated, any difference between analyzers exceeded the MAD.

Conclusions
The EP31-A-IR guideline proved to be useful for periodic verification of results’ comparability. However, it must be considered that, to be practicable, it may require to adjust the acceptance criteria in accordance to the analytical performance of the available technology; as well as the number of analytical measurements conforming to the laboratory resources.
Chemical Quest: general knowledge and popular culture quizzes about the elements in a board game for the class
Authors: Bortoli Marco , Balasso Antonella , Carta Giovanni , Cestaro Maristella , Colla Viviana , De Togni Alessandra , Gallani Giulio , Giacometti Cristina , Gianni Laura , Giuffreda Lucia , Granella Manuela , Iarabek Marina , Lion Enrico , Mazzi Giuseppe , Migale Caterina , Milan Stefano , Molesini Paola , Moretto Mara , Predonzan Roberta , Priolisi Ornella , Romualdi Rosella , Rubini Cristina , Scarfì Sandra , Tobaldini Elena , Dalla Tiezza Marco , Nale Enrico , Bellanda Massimo , Kennedy Gordon , Sella Gianpietro , Lanza Alessandro , Orian Laura 
Published: October 2023

Abstract
Chemical Quest is an innovative trivia game based on the 102 elements of the periodic table from H to No, developed collaboratively by upper secondary school and university teachers with the aim of increasing the interest of young students (age 14–18) in chemistry. As part of the project, a software version of the game was successfully played in 24 classes. ‘Challenging, sometimes difficult, highly instructive, relaxing, captivating, ….’ are some of the positive comments by students and teachers. In addition, Chemical Quest was conceived to be adaptable since the rules can be modified and the cards can be selected to match the educational objective.
Effect of adverse slope on performance of USBR II stilling basin
Authors: Saleh Layla Ali Mohammed , Khassaf Saleh Issa 
Published: October 2023

AbstractThis article focuses on the United States Bureau of Reclamation (USBR) Type II stilling basin, which has chute blocks, an end dentated sill, and a flat floor. USBR provides general design criteria to contain the hydraulic jump within the stilling basin. The sequent depth ratio, energy dissipation ratio, and stilling basin dimensions of the hydraulic jump are changed when the bed slope of USBR II stilling basins is changed. This study aimed to investigate the effects of adverse slope on the performance of USBR II stilling basin in terms of sequent depth ratio and energy dissipation. Six discharges ranging from 8 to 33 lps were applied to the USBR II stilling basin with bed slopes (S) of −0.085, −0.055, −0.035, and 0. Results demonstrated that forQ= 13 and 8 lps, the basin performs better than other models withS= −0.085, increasing energy dissipation by about 10% compared to a typical basin due to the formation of a free hydraulic jump downstream dentated end sill. On the other hand, the floor downstream of the dentated end sill needs more protection against this free jump, and this case becomes economically expensive. In other cases, the downstream jump was submerged, resulting in a counterintuitive current and reverse roller based on the submerged ratio, reducing the effectiveness of the stilling basin. In addition, the modified design of the stilling basin resulted in a shorter effective length that included the hydraulic jump downstream spillway, thereby reducing internal friction. As a result, the standard USBR II with a flatbed is less expensive and more efficient than the adverse slope basin.
Wet-chemical synthesis of sponge-like porous Zn-doped copper oxide ceramic as an efficient solar-light triggered photocatalyst for multiple applications
Authors: Alabada Rusul , Aadil Muhammad , Mubarik Shamroza , Alsalmah Hessa A. , Hassan Warda , Ahmad Zubair , Ibrahim Mohamed M. , Mersal Gaber A. M. 
Published: October 2023

Abstract
This work presents a simple co-precipitation method for making Zn-doped copper oxide (C1−x
(Zn)
x
O) that is nanostructured, porous, active in visible light, and highly conductive. The combined impacts of doping, structural modifications, and nanoscaled synthesis contribute to the development of a novel catalyst that has inherent characteristics. Physicochemical studies confirm the coexistence of all desired features in the C1−x
(Zn)
x
O photocatalyst. The formed photocatalyst’s dye-destroying and antimicrobial properties were carefully examined and compared to those of pristine copper oxide (PCO) that had not been doped. When tested against Escherichia coli (a “negative strain”) and Staphylococcus aureus (a “positive strain”), the antimicrobial properties of the C1−x
(Zn)
x
O photocatalyst were better than those of PCO and on par with those of commercially available drugs. Also, C1−x
(Zn)
x
O photocatalyst gets rid of reactive orange 4 (RO-4) dye more effectively and faster (0.023 min−1) than PCO photocatalyst (0.11 min−1) by using simple sorption and photocatalytic annihilation. The C1−x
(Zn)
x
O photocatalyst eliminated 90.25 % of RO-4 dye under visible light irradiation. Under identical circumstances, the PCO photocatalyst removed 65.12 % of the RO-4 dye. The boosted bactericidal and photocatalytic activity of the C1−x
(Zn)
x
O photocatalyst may be attributed to its larger surface area (56.5 m2 g−1), good electrical conductivity (2.33 × 10−3 S m−1), low bandgap (1.98 eV), and doping-induced structural defects. The developed features increase the light-capturing sites on the catalyst surface, improve the charge transport kinetics, enable the catalysts to harvest visible light, and limit the charge recombination process, allowing our photocatalyst to show exceptional bactericidal and dye annihilation activities. This study opens new avenues for developing metal-substituted metal oxides with porous nanostructures for environmental and ecological protection.
Analysis of In-Season External Load and Sport Performance in Women’s Collegiate Basketball
Authors: Brown Faith S.A. , Fields Jennifer B. , Jagim Andrew R. , Baker Robert E. , Jones Margaret T. 
Published: October 2023

Abstract
Brown, FSA, Fields, JB, Jagim, AR, Baker, RE, and Jones, MT. Analysis of in-season external load and sport performance in women’s collegiate basketball. J Strength Cond Res 38(2): 318–324, 2024—Quantifying and monitoring athlete workload throughout a competitive season is a means to manage player readiness. Therefore, the purpose of the current study was to quantify practice and game external loads and to assess the relationship between such loads and basketball-specific performance metrics across a women's collegiate basketball season. Thirteen National Collegiate Athletic Association Division I women basketball athletes (age 20.08 ± 1.55 years) wore Global Positioning Systems sensors equipped with triaxial accelerometers for 29 games and 66 practices during the 2019–20 season. A multivariate analysis of variance was used to assess differences in external load between high- and low-minute players and across quarters within games (p < 0.05). Bivariate Pearson correlation coefficients were run to determine relationships between external loads and metrics of basketball performance. Findings indicated that high- and low-minute athletes experienced different loads during games and practices (p < 0.001). External loads differed by quarter, such that player load (PL) was highest in Q4 (p = 0.007), PL·min−1 was highest in Q1 and lowest in Q4 (p < 0.001), and explosive ratio (i.e., ratio of PL and explosive efforts) was lowest in Q3 (p = 0.45). Relationships existed between PL·min−1 and field goals (r = 0.41; p = 0.02) and between the explosive ratio and free throws (r = 0.377 p = 0.04). These results can be used to inform design of training sessions with the intent to prepare athletes for the demands of the competitive season. It is recommended that future research continue to explore the relationship of sport-specific performance metrics and athlete external load.
Heat transfer model for dropwise condensation on hydrophobic and superhydrophobic interfaces
Authors: YUVARAJ R. , SENTHILKUMAR D. 
Published: October 2023

Heat transfer models for condensation on hydrophobic and superhydrophobic interfaces are broadly available based on thermal resistance correlations. In the previous studies, very few models are presented based on the scaling factor or Nusselt number, and no model is available that directly correlates Biot number. This study develops a heat transfer model for dropwise condensation underneath a horizontal surface. The present model correlates with the Biot number to predict the heat transfer, temperature variation at the interfaces, solid-liquid, and liquid-vapor, and the growth rate of droplet condensate on the hydrophobic and superhydro-phobic interfaces by using Archimedes’ hat-box theorem. The present model is validated with analytical and experimental results against hydrophobic and superhydrophobic contact angles of similar working parameters made excellent agreements. The analytical model for dropwise condensation produces inaccurate results due to discrepancies and discontinuities due to mul-tiple correlations in the modeling. The present model is modified to obtain a continuous result using experimental data. The modified model is used for analyzing heat transfer by varying Biot numbers from 0.0001 to 1000 using Python 3.6.1 with an accuracy of 10-4. Simulation of the present model results in constant heat transfer at Bi = 4, irrespective of the contact angle. A negligible amount of coating resistance and interface resistance when Bi > 0.1, curvature effect when Bi > 0.04, droplet resistance when Bi < 0.02, the maximum liquid-vapor interface tem-perature at Bi ≈ 10, and maximum solid-liquid interface temperature at Bi ≈ 5, are presented.
ASCENSO SOCIAL A TRAVÉS DE LOS COLEGIOS MAYORES SALMANTINOS. LOS CASOS DE LOS CORDOBESES TORQUEMADA Y TORQUEMADA SAN CLEMENTE / SOCIAL UPGRADING THROUGH THE COLEGIOS MAYORES OF SALAMANCA. THE CASES OF THE TORQUEMADAS AND THE TORQUEMADA SAN C
Authors: Barrado Jiménez Isabel 
Published: October 2023

(ES)Resumen: Mediante el análisis de dos expedientes de ingreso de la parentela cordobesa de los Torquemada y Torquemada San Clemente y el cruce de fuentes, trataremos de demostrar en este artículo la incapacidad de los Estatutos de Limpieza de Sangre de los Colegios Mayores salmantinos para servir de barrera a la entrada de conversos en su seno, y, por tanto, la existencia de la posibilidad de un ascenso social de este colectivo en la España Moderna, y todo lo que se esconde detrás de este proceso.Palabras clave: Limpieza de sangre, Ascenso social, Colegios Mayores de Salamanca, Torquemada, Torquemada San Clemente.(EN)Abstract: By the analysis of the two joining files that exist about the cordovan family “Torquemada” or “Torquemada San Clemente” in the salamancan Colegios Mayores, along with checking against other documents, we try to prove in this paper that the rules set to prevent people with Jewish blood from getting inside these establishments were completely useless. And therefore, that the possibility to socially upgrade in the sixtieth and seventieth centuries was always there, even though, in some cases, purposely hiding.Key words: Limpieza de sangre, Social upgrading, Colegios Mayores of Salamanca, Torquemada, Torquemada San Clemente.
Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates
Authors: Xu Wen-Jie , Zhu Chenglong , Gao Xueli , Wu Baosheng , Xu Han , Hu Ming-Liang , Zeng Honghui , Gan Xiaoni , Feng Chen-Guang , Zheng Jiangmin , Bo Jing , He Lisheng , Qiu Qiang , Wang Wen , He Shunping , Wang Kun 
Published: October 2023

Abstract

As the deepest vertebrate in the ocean, the hadal snailfish (Pseudoliparis swirei), which lives at a depth of 6,000~8,000m, is a representative case for studying adaptation to extreme environments. Despite some preliminary studies on this species in recent years, including their loss of pigmentation, visual and skeletal calcification genes, and the role of TMAO in adaptation to high-hydrostatic pressure, it is still unknown how they evolved and why they are among the few vertebrate species that have successfully adapted to the deep sea environment. Using genomic data from different trenches, we found that the hadal snailfish may have entered and fully adapted to such extreme environments only in the last few million years. Meanwhile, phylogenetic relationships show that they spread into different trenches in the Pacific Ocean within a million years. Comparative genomic analysis has also revealed that the genes associated with perception, circadian rhythms, and metabolism have been extensively modified in the hadal snailfish to adapt to its unique environment. More importantly, the tandem duplication of a gene encoding ferritin significantly increased their tolerance to reactive oxygen species, which may be one of the important factors in their adaptation to high-hydrostatic pressure.