bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Menu Olahan Ikan Hasil Akuakultur untuk Meningkatkan Ketahanan Pangan Lokal di Buraen
Authors: Pasaribu Wesly , Pah Theny Intan Berlian Kurniati , Suleman  , Sogen Katharina Desembrianty P. , Ngefak Putra Marco , Neolaka Grace Oni Oet 
Published: December 2023

Produk dari kegiatan akuakuktur memiliki peranan penting dalam mengatasi masalah yang berkaitan dengan nutrisi pada masyarakat. Pengabdian Masyarakat di Kolam Akuakultur Nunneo Buraen ini bertujuan untuk memberikan informasi terkait manfaat makan ikan terutama untuk pencegahan stunting dan pelatihan olahan ikan Lele (Clarias sp.) yang diperoleh dari hasil kegiatan akuakultur. Subjek pengabdian ini yaitu Masyarakat Buraen sekitar kolam Ikan Nunneo dan Mitra Kelompok Tani Tunas Muda Buraen. Tahapan pengabdian dilakukan mulai dari : (1) penyulunan tentang stunting dan manfaat makan ikan serta pengenalan produk ikan hasil akuakultur bernilai gizi tinggi (2) pelatihan pembuatan olahan ikan hasil akuakultur menjadi produk pentol “Salome” bakar. Evaluasi akhir yang dilakukan yaitu evaluasi paska mengikuti kegiatan dan diperoleh hasil bahwa masyarakat memperoleh peningkatan pemahaman/pengetahuan tentang stunting, manfaat makan ikan hasil akuakultur serta diperoleh peningkatan keterampilan pembuatan olahan pangan ikan dari ikan lele yaitu berupa Salome bakar.
Exploring sex differences in lung cancer risk among workers in Ontario, Canada's Occupational Disease Surveillance System
Authors: Sritharan Jeavana , Christopher Gabriella , Eros Fanni R. , Demers Paul A. 
Published: December 2023

BackgroundWhile it is well-established that occupational exposures significantly contribute to the risk of developing lung cancer, there remains a notable gap in understanding the specific sex differences in lung cancer risk, particularly among female workers. This study aimed to examine sex differences in lung cancer risk across various occupations, with an emphasis on the female workforce.MethodsA cohort of approximately 2.37 million workers with lost-time compensation claims were linked to the Ontario Cancer Registry and followed until lung cancer diagnosis, age 85, emigration, death, or end of follow-up (Dec 31, 2020). Cox proportional hazards models were used to estimate sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer by occupational group (division, major and minor levels), adjusted for birth-year and age and indirectly adjusted for cigarette smoking.ResultsA total of 12,216 and 30,291 incident lung cancer cases were identified among females and males, respectively. Several occupations demonstrated stronger associations for lung cancer in females, with at least a 20% increased risk compared to males. These occupations at the major level include food and beverage preparation services (HR = 1.19, 95% CI = 1.13–1.26); materials processing (chemical, petroleum, rubber, plastic) (HR = 1.35, 95% CI = 1.19–1.52); wood processing (HR = 1.87, 95% CI = 1.22–2.87); metal machining (HR = 1.56, 95% CI = 1.21–2.00); metal shaping and forming (HR = 1.46, 95% CI = 1.32–1.62); fabricating and assembling metal products (HR = 1.37, 95% CI = 1.25–1.51), other construction trades (HR = 1.54, 95% CI = 1.16–2.05), motor transport operating (HR = 1.69, 95% CI = 1.48–1.94), mechanic and repair work (HR = 1.39, 95% CI = 1.04–1.85); and printing (HR = 1.51, 95% CI = 1.30–1.75). These patterns were similar across minor level occupations.ConclusionsThis study identified sex differences across various occupations, with some occupational groups demonstrating stronger associations among female workers. However, these findings should be interpreted with caution. The observed differences may be attributed to various factors that influence risk, such as occupational exposures, use and effectiveness of personal protective equipment, and other biological or lifestyle factors.
Light-enhanced VEGF121/rGel induce immunogenic cell death and increase the antitumor activity of αCTLA4 treatment
Authors: Longva Ane Sager , Berg Kristian , Weyergang Anette 
Published: December 2023

BackgroundImmune-checkpoint inhibitors (ICIs) represent a revolution in cancer therapy and are currently implemented as standard therapy within several cancer indications. Nevertheless, the treatment is only effective in a subset of patients, and immune-related adverse effects complicate the improved survival. Adjuvant treatments that can improve the efficacy of ICIs are highly warranted, not only to increase the response rate, but also to reduce the therapeutic ICI dosage. Several treatment modalities have been suggested as ICI adjuvants including vascular targeted treatments and photodynamic therapy (PDT). Photochemical internalization (PCI) is a drug delivery system, based on PDT. PCI is long known to generate an immune response in murine models and was recently shown to enhance the cellular immune response of a vaccine in a clinical study. In the present work we evaluated PCI in combination with the vascular targeting toxin VEGF121/rGel with respect to induction of immune-mediated cell death as well as in vitro ICI enhancement.MethodsDAMP signaling post VEGF121/rGel-PCI was assessed in CT26 and MC38 murine colon cancer cell lines. Hypericin-PDT, previously indicated as an highly efficient DAMP inducer (but difficult to utilize clinically), was used as a control. ATP release was detected by a bioluminescent kit while HMGB1 and HSP90 relocalization and secretion was detected by fluorescence microscopy and western blotting. VEGF121/rGel-PCI was further investigated as an αCTLA enhancer in CT26 and MC38 tumors by measurement of tumor growth delay. CD8+ Dependent efficacy was evaluated in vivo using a CD8+ antibody.ResultsVEGF121/rGel-PCI was shown to induce increased DAMP signaling as compared to PDT and VEGF121/rGel alone and the magnitude was found similar to that induced by Hypericin-PDT. Furthermore, a significant CD8+ dependent enhanced αCTLA-4 treatment effect was observed when VEGF121/rGel-PCI was used as an adjuvant in both tumor models.ConclusionsVEGF121/rGel-PCI describes a novel concept for ICI enhancement which induces a rapid CD8+ dependent tumor eradication in both CT26 and MC38 tumors. The concept is based on the combination of intracellular ROS generation and vascular targeting using a plant derived toxin and will be developed towards clinical utilization.
Risk of osteoarthritis in patients with hidradenitis suppurativa: a global federated health network analysis
Authors: Chang Hui-Chin , Wu Chih-Lung , Chiu Tsu-Man , Liao Wen-Chieh , Gau Shuo-Yan 
Published: December 2023

BackgroundOsteoarthritis and hidradenitis suppurativa (HS) share a common inflammatory pathway. However, whether patients with HS have higher risk developing osteoarthritis remained unclear.MethodsA retrospective cohort design was adopted in this study. Electronic medical records had been retrieved from the US collaborative network in the TriNetX research network. A propensity score matching of 1:1 was performed to match for covariates. In total, 50,931 patients with HS and the same amount of non-HS controls were identified for analyses. Hazard ratio (HR) of osteoarthritis in patient with HS was calculated.ResultsRisk of patients with HS developing osteoarthritis was 1.37-fold higher than that of non-HS controls [95% confidence interval (CI), 1.21–1.55] when followed up for 1 year. The significance remained when the follow-up periods were extended to 3 years and 5 years. When osteoarthritis was stratified on occurring sites, the HR of knee osteoarthritis was 1.19 (95% CI, 1.09–1.29) and the HR of hip osteoarthritis was 1.17 (95% CI, 1.01–1.35) in the 5-year follow-up. The 5-year risk of osteoarthritis remained significant in sensitivity models.ConclusionPatients with HS were of high risk of developing osteoarthritis compared with people without HS. The clinical association was recommended to be considered while approaching patients with HS.
Identifying the programmed cell death index of hepatocellular carcinoma for prognosis and therapy response improvement by machine learning: a bioinformatics analysis and experimental validation
Authors: Shi Yuanxin , Feng Yunxiang , Qiu Peng , Zhao Kai , Li Xiangyu , Deng Zhengdong , Wang Jianming 
Published: December 2023

BackgroundDespite advancements in hepatocellular carcinoma (HCC) treatments, the prognosis for patients remains suboptimal. Cumulative evidence suggests that programmed cell death (PCD) exerts crucial functions in HCC. PCD-related genes are potential predictors for prognosis and therapeutic responses.MethodsA systematic analysis of 14 PCD modes was conducted to determine the correlation between PCD and HCC. A novel machine learning-based integrative framework was utilized to construct the PCD Index (PCDI) for prognosis and therapeutic response prediction. A comprehensive analysis of PCDI genes was performed, leveraging data including single-cell sequencing and proteomics. GBA was selected, and its functions were investigated in HCC cell lines by in vitro experiments.ResultsTwo PCD clusters with different clinical and biological characteristics were identified in HCC. With the computational framework, the PCDI was constructed, demonstrating superior prognostic predictive efficacy and surpassing previously published prognostic models. An efficient clinical nomogram based on PCDI and clinicopathological factors was then developed. PCDI was intimately associated with immunological attributes, and PCDI could efficaciously predict immunotherapy response. Additionally, the PCDI could predict the chemotherapy sensitivity of HCC patients. A multilevel panorama of PCDI genes confirmed its stability and credibility. Finally, the knockdown of GBA could suppress both the proliferative and invasive capacities of HCC cells.ConclusionThis study systematically elucidated the association between PCD and HCC. A robust PCDI was constructed for prognosis and therapy response prediction, which would facilitate clinical management and personalized therapy for HCC.
Anti-SRP immune-mediated necrotizing myopathy responsive to ofatumumab: a case report
Authors: Chen Sihui , Yang Jing , He Du , Fu Jiajia , Lai Xiaohui , Zhao Bi , Chen Xueping , Shang Huifang 
Published: December 2023

BackgroundImmune-mediated necrotizing myopathies (IMNM) is a rare disease that was first described in 2004. Due to the lack of large case series, there are no formal treatment recommendations for IMNM.MethodsWe presented a case of a 47-year-old woman who experienced progressive limb weakness, starting from the lower limbs and gradually affecting the upper limbs. She also reported experiencing dyspnea after engaging in daily activities. When she was admitted to the hospital, her upper limbs were almost unable to move and she could not stand even with support. Her Creatine kinase (CK) level significantly increased (&gt; 3500 u/l). Electromyography showed myogenic damage, anti-Signal recognition particle (anti-SRP) and anti-Ro52 antibodies were highly positive. Pathological biopsy of the right biceps muscle showed necrotizing myopathy in the skeletal muscle. She was ultimately diagnosed with anti-SRP IMNN, and was given monotherapy with methylprednisolone and combination therapy with immunoglobulin, but her symptoms continued to worsen. The patient refused to bear the possible further liver dysfunction and blood system damage caused by Cyclophosphamide and Rituximab, and she chose to try to use Ofatumumab (OFA).ResultsAfter receiving three doses of OFA treatment without any adverse reactions, she reported that her muscle strength had basically recovered and she was able to walk independently. The B cells in the circulatory system have been depleted, and blood markers such as liver function have consistently remained within normal range. During the follow up, her activity tolerance continued to improve.DiscussionWe have presented a severe case of SRP-IMNM in which the patient showed poor response to conventional immunotherapy. However, rapid symptom relief was achieved with early sequential use of OFA treatment. This provides a new option for the treatment of SRP-IMNM, and more large-scale studies will be needed in the future to verify our results.
Butyrate interacts with the effects of 2’FL and 3FL to modulate in vitro ovalbumin-induced immune activation, and 2’FL lowers mucosal mast cell activation in a preclinical model for hen’s egg allergy
Authors: Zuurveld M. , Diks M. A. P. , Kiliaan P. C. J. , Garssen J. , Folkerts G. , van’t Land B. , Willemsen L. E. M. 
Published: December 2023

BackgroundEarly life provides a window of opportunity to prevent allergic diseases. With a prevalence of 0.5–2% in infants, hen’s egg allergy is one of the most common food allergies. The immunomodulatory effects of human milk oligosaccharides (HMOs), 2′-fucosyllactose (2’FL), and 3-fucosyllactose (3FL) were studied in an in vitro mucosal immune model and an in vivo murine model for hen’s egg (ovalbumin) allergy.MethodsIntestinal epithelial cell (IEC)/dendritic cell (DC) and DC/T cell cocultures were used to expose IECs to ovalbumin (OVA) in an in vitro mucosal immune model. The effects of epithelial pre-incubation with 0.1% 2’FL or 3FL and/or 0.5 mM butyrate were studied. Three- to four-weeks-old female C3H/HeOuJ mice were fed AIN93G diets containing 0.1–0.5% 2’FL or 3FL 2 weeks before and during OVA sensitization and challenge. Allergic symptoms and systemic and local immune parameters were assessed.ResultsExposing IECs to butyrate in vitro left the IEC/DC/T cell cross-talk unaffected, while 2’FL and 3FL showed differential immunomodulatory effects. In 3FL exposed IEC-DC-T cells, the secretion of IFNγ and IL10 was enhanced. This was observed upon pre-incubation of IECs with 2’FL and butyrate as well, but not 2’FL alone. The presence of butyrate did not affect OVA activation, but when combined with 3FL, an increase in IL6 release from DCs was observed (p &lt; 0.001). OVA allergic mice receiving 0.5% 3FL diet had a lower %Th2 cells in MLNs, but the humoral response was unaltered compared to control mice. OVA-allergic mice receiving 0.1 or 0.5% 2’FL diets had lower serum levels of OVA-IgG2a (p &lt; 0.05) or the mast cell marker mMCP1, in association with increased concentration of cecal short-chain fatty acids (SCFAs) (p &lt; 0.05).ConclusionIn vitro butyrate exposure promotes the development of a downstream type 1 and regulatory response observed after 2’FL exposure. 2’FL and 3FL differentially modulate ovalbumin-induced mucosal inflammation predominantly independent of butyrate. Mice receiving dietary 3FL during ovalbumin sensitization and challenge had lowered Th2 activation while the frequency of Treg cells was enhanced. By contrast, 2’FL improved the humoral immune response and suppressed mast cell activation in association with increased SCFAs production in the murine model for hen’s egg allergy.
Detectable ctDNA at the time of treatment cessation of ipilimumab and nivolumab for toxicity predicts disease progression in advanced melanoma patients
Authors: Warburton Lydia , Reid Anna , Amanuel Benhur , Calapre Leslie , Millward Michael , Gray Elin 
Published: December 2023

BackgroundImmune checkpoint inhibition (ICI) has led to unprecedented outcomes for melanoma patients but is associated with toxicity. ICI resumption after high grade irAEs poses a significant challenge in the clinical management of melanoma patients and there are no biomarkers that can help identify patients that might benefit from resuming treatment. This study aims to determine if circulating tumor DNA (ctDNA) levels at the time of treatment-limiting irAE could guide treatment decisions in this clinical context.MethodsThis is a retrospective exploratory biomarker study from 34 patients treated with combination ICI for stage IV melanoma. Patients had a treatment-limiting toxicity and a baseline plasma collection prior to commencing ICI and within 6 weeks of stopping therapy. Blood samples were tested for ctDNA at baseline and cessation therapy.ResultsMedian progression free survival (PFS) and overall survival (OS) have not been reached (24-month PFS rate 54% and OS rate 72.3%). PD occurred in 47% (16/34) of patients. Median PFS with detectable ctDNA from plasma collected at the time of toxicity was 6.5 months while not reached (NR) with undetectable levels (HR: 4.0, 95% CI 0.95-17.5, p=0.0023). Median OS with detectable ctDNA at cessation for toxicity was 19.4 months and NR for undetectable ctDNA (HR: 3.9, 95%CI 20.8-18.6, p=0.024). Positive ctDNA at the time of cessation was highly specific (specificity 0.94, 95% CI 0.74-0.99, PPV 0.88, 95% CI 0.53-0.99). However, ctDNA negativity has low sensitivity as a predictor of ongoing disease control (sensitivity 0.437, 95% CI 0.23-0.67). Notably, 4/9 (44%) ctDNA negative patients who had disease progression had brain only disease progression.ConclusionsUndetectable ctDNA and CR on imaging after stopping immunotherapy for toxicity results in high rates of long-term durable control. For patients with immunotherapy related toxicity, who have persistent ctDNA at 8 – 12 weeks, the risk of disease progression is significant.
Evaluation of the Spiranthes spiralis Population’s Phenotypic Density in the Plant Community of Medicagini minimae–Festucetum valesiacae Meadows in the Natura 2000 Jiului Corridor Site, Romania (ROSCI0045)
Authors: Niculescu Mariana , Păniță Ovidiu Florin , Iancu Paula , Făgăraș Marius Mirodon 
Published: December 2023

There are few reports related to the presence of Spiranthes spiralis in the Oltenia region in southern Romania. This study develops the information concerning the presence of this type of orchid in Gorj County. The studies on the populations of this orchid species have been conducted in the Natura 2000 site of the Community ROSCI0045 Jiului Corridor. In the researched territory, during the investigations, twelve populations of Spiranthes spiralis were sampled for the first time. In 2022–2023, we studied the distribution of this species and assessed its population densities. Our observations indicate that it is a relatively widespread species in the studied area and its populations are more abundant in meadows, in the Medicagini minimae–Festucetum valesiacae plant community.
Osmanlı Dönemine Ait Bazı Gramerlerde ve Derlemelerde Kayıtlı Atasözlerinde Sayı Adları
Authors: ÇETİN Engin 
Published: December 2023

Atasözleri milletlerin düşünüş tarzını, hayata ve olaylara bakış açısını ortaya koyan, milleti oluşturan bireylerin, üzerinde uzlaşıp kalıplaştırarak yaygınlaşmasını sağladığı dil unsurlarıdır. Bu sebeple atasözleri, derlemelerden edebiyat ve günlük hayatta kullanılışına her millet için geçmişten günümüze vazgeçilmez olmuş, her kesimden insanın ilgisini çekmiştir.
Birçok araştırmacı için Türk atasözlerinin ilk tespit edildiği kaynak Orhon Yazıtları’dır. Burada geçen birtakım cümleler yapı ve anlam bakımından atasözlerini andırdığından bu sözler atasözü olarak kabul edilmiştir ancak çok sayıda atasözünün bilinçli şekilde derlendiği ilk eser Divânu Lugâti’t-Türk’tür. Anadolu’daki en eski atasözü mecmuası olarak 15. yüzyıla ait hazırlayıcısı bilinmeyen, Kitâb-ı Atalar adlı eser kabul edilmektedir. Bu tarihten sonra da Osmanlı döneminde atasözlerimiz değişik coğrafyalarda yerli ve yabancı müellifler tarafından birçok kez derlenip kayıt altına alınmıştır. Bu çalışmada Osmanlı döneminde derlenmiş atasözlerimizdeki sayı adları ele alınacaktır. Sayılar geçmişten günümüze her millet için bütün inanç sistemlerinde ve kültürlerde önemsenmiştir. Bu bakımdan sayılar da atasözleri gibi milletlerin hayata ve olaylara bakışını yansıtan, dil ve kültür ilişkisini en güçlü şekilde ortaya koyan dil unsurlarından kabul edilmektedir. Atasözlerimizde sayı adları çoğu zaman azlık-çokluk ilişkisi bağlamında zıt unsurlar olarak ele alınmıştır. Az kavramı bir veya hiç sözcükleriyle karşılanırken çokluk kavramı için bazen iki sözcüğü gibi çokluğu çok yansıtmayan sayı adı bazen de yüz, biŋ gibi ikiye oranla görece çokluk bildiren sayı adları kullanılmıştır. Atasözlerimizde birden ona kadar sayı adları yanında kırk, yüz, biŋ vb. çok çeşitli sayı adları geçmektedir. Ancak çift sayı adlarından çok tek sayı adlarının kullanılması dikkat çekicidir. Çalışmada, söz konusu sayı adlarının temsil ettiği değerler üzerinde durulacak, sayıların atasözlerindeki işlevleri ele alınacaktır.
Hubungan Inisiasi Menyusu Dini Dengan Suhu Tubuh Bayi Baru Lahir
Authors: Ari Widyaningsih  , Pirawati  
Published: December 2023

Masa transisi bayi merupakan masa yang sangat kritis pada bayi dalam upaya untuk dapat bertahan hidup. Bayi baru lahir harus beradaptasi dengan kehidupan di luar uterus yang suhunya jauh lebih dingin bila dibandingkan suhu didalam uterus yang relatif lebih hangat sekitar 37ºC. Bayi tidak bisa mengatur suhu tubuh mereka sehingga akan mengalami stres dengan perubahan lingkungan. Kulit dada ibu yang melahirkan 1º C lebih panas dari ibu yang tidak melahirkan. Dada ibu menghangatkan bayi dengan tepat selama merangkak mencari payudara. Tujuan dari penelitian ini untuk mengetahui hubungan inisiasi menyusui dini dengan suhu tubuh bayi baru lahir. Metode penelitian yang digunakan adalah kuantitatif korelasi dengan menggunakan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh bayi baru lahir dari bulan Mei-November tahun 2022. Jumlah sampel 60 orang teknik pengambilan sampel menggunakan total sampling. Hasilnya terdapat hubungan yang signifikan antara inisiasi menyusu dini dengan suhu tubuh bayi baru lahir dengan hasil nilai p value 0,000 < 0,05. Kesimpulan pada penelitian ini diketahui bahwa bayi baru lahir yang diberikan IMD mayoritas memiliki suhu tubuh normal yaitu ntara 36,5°C – 37,5°C ada 40 (66,7%).
EVALUATION OF THE DETERMINATION OF IT INFRASTRUCTURE PERSONNEL IN THE AL NAVY USING A COMBINATION OF AHP AND VIKOR METHODS
Authors: Abdillah Abdillah Imam Julianto , H.A Danang Rimbawa  , Yudistira Asnar  
Published: December 2023

In the current development of technology, information technology is not only used in the economic field, but is divided into various fields, including the military world of the Navy. In order to promote the capability of human resources in the field of IT infrastructure in the Navy, it is necessary to select the right personnel in the maintenance of IT infrastructure assets, so as to obtain competent personnel output in answering future challenges. To facilitate the determination of the right IT infrastructure personnel, the author implements a system by combining the AHP and Vikor methods based on Python. The AHP method is used to determine the weight of criteria in the selection of IT personnel, and the Vikor method is used to rank the appropriate IT personnel. With this system, it is hoped that it can be a supporting application to help select IT personnel according to tactical, technical, strategic criteria.
Company Profile Information System for Sematangborang District Office Based on Website
Authors: Susanti Eva , Ariati Nining , Saluza Imelda 
Published: December 2023

Website Company profile adalah website yang menampilkan informasi tentang latar belakang perusahaan, produk atau jasa, informasi kontak dan berita singkat tentang perusahaan. Saat ini, Kantor Kecamatan Sematangborang menyampaikan informasinya hanya melalui spanduk, brosur, surat dan baliho yang membutuhkan biaya dan waktu yang lebih banyak. Banyak masyarakat yang tidak mengetahui tentang Informasi Pelayanan dan Profil Kantor Kecamatan Sematangborang dikarenakan minimnya informasi. Dengan keadaan tersebut maka dengan ini penulis tertarik menyusun kegiatan penelitian ini dengan mengambil judul “Sistem Informasi Company Profile Kantor Kecamatan Sematangborang Berbasis Website”. Diharapkan dengan adanya Sistem Informasi tersebut memudahkan masyarakat dalam mendapatkan informasi tentang profil Kantor Kecamatan Sematangborang. Menggunakan bahasa pemrograman PHP, database MySQL. Metode pengembangan perangkat lunak yang akan digunakan dalam penelitian ini adalah metode Waterfall dengan tahapan meliputi analysis, design, coding dan testing. Pengujian sistem informasi ini dilakukan dengan metode blackbox testing.