bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of health education program on knowledge, stress, and satisfaction among infertile women undergoing in vitro fertilization injection
Authors: Mohamed Heba M. , Badia Treza S. , Khalaf Shimaa A. , Abdullah Saleh O. , Farghaly Tarek A. , Fetih Ahmed N. , Aly Shimaa Elwardany 
Published: January 2024

Abstract
Background
Stress and dissatisfaction are common issues among patients undergoing in vitro fertilization (IVF). The process of IVF can be emotionally and psychologically challenging, leading to stress, anxiety, and depression in patients. This can be exacerbated by factors such as the length of infertility, the uncertainty of the outcome, and the financial burden of treatment. Additionally, the physical demands of the treatment, the side effects of medication, and the fear of failure can contribute to dissatisfaction and emotional strain in IVF patients. This pre-post intervention study design aimed to evaluate the effect of a health education program on knowledge, stress, and satisfaction among 100 infertile women undergoing IVF attending the Woman’s Health Hospital’s infertility outpatient clinic and IVF unit at Assiut University. Knowledge and stress were measured by women’s knowledge about IVF and the perceived stress scale, respectively. The satisfaction was measured using the Scale of Patient Satisfaction about IVF.

Results
There is a marked improvement in the knowledge of infertile women, with a significant reduction in their stress levels after the health education program. Furthermore, the satisfaction scores of the women who participated in the program improved significantly.

Conclusion
The health education program demonstrated a positive impact on knowledge, stress levels, and satisfaction among infertile women undergoing IVF. These findings highlight the positive impact of the program on the participants and emphasize the importance of continuous educational programs regarding IVF to improve knowledge, decrease stress levels, and increase their overall satisfaction with the treatment.
LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings
Authors: El-Sayed Kefaya , Youssef Amany R. , Hay Nehal M. Abdel , Osman Adel M. 
Published: January 2024

Abstract
Background
Coronary artery disease (CAD) is the main cause of death in Egypt. Many LDL-R gene locus single nucleotide polymorphisms (SNP) are found to be associated with the risk of CAD. This research aimed to assess the allelic and genotypic frequencies of rs1122608 SNP and their association with the extent of vessel affection and lipid profile in a population of Egyptians.100 CAD patients and 100 healthy controls of Egyptians were included. PCR–RFLP was used to genotype rs1122608 SNPs.

Results
Significantly higher proportion of ‘T’ allele among patient (risk allele). This association is of low strength (ϕ lies between 0.1 and 0.3). A participant with ‘T’ allele has 1.95 times higher odds to exhibit CAD versus a participant with ‘G’ allele. Significantly higher proportion of ‘T/T’ genotype among cases versus control (risk genotype). This association is of low strength (Cramer’s V lies between 0.1 and 0.3). A participant with ‘T/T’ genotype has 4.5 times higher odds to exhibit CAD versus a participant with ‘G/G’. Gensini score showed no significant association with rs1122608 genotypes (p = 0.863).

Conclusions
The mutant GT and TT genotypes and minor T allele of rs1122608 were positively correlated with CAD and considered as independent risk factors for CAD.
Evaluating the index of panoramic X-ray image quality using K-means clustering method
Authors: Imajo Satoshi , Tanabe Yoshinori , Nakamura Nobue , Honda Mitsugi , Kuroda Masahiro 
Published: January 2024

Abstract
Background
A panoramic X-ray image is generally considered optimal when the occlusal plane is slightly arched, presenting with a gentle curve. However, the ideal angle of the occlusal plane has not been determined. This study provides a simple evaluation index for panoramic X-ray image quality, built using various image and cluster analyzes, which can be used as a training tool for radiological technologists and as a reference for image quality improvement.

Results
A reference panoramic X-ray image was acquired using a phantom with the Frankfurt plane positioned horizontally, centered in the middle, and frontal plane centered on the canine teeth. Other images with positioning errors were acquired with anteroposterior shifts, vertical rotations of the Frankfurt plane, and horizontal left/right rotations. The reference and positioning-error images were evaluated with the cross-correlation coefficients for the occlusal plane profile, left/right angle difference, peak signal-to-noise ratio (PSNR), and deformation vector fields (DVF). The results of the image analyzes were scored for positioning-error images using K-means clustering analysis. Next, we analyzed the correlations between the total score, cross-correlation analysis of the occlusal plane curves, left/right angle difference, PSNR, and DVF. In the scoring, the positioning-error images with the highest quality were the ones with posterior shifts of 1 mm. In the analysis of the correlations between each pair of results, the strongest correlations (r = 0.7–0.9) were between all combinations of PSNR, DVF, and total score.

Conclusions
The scoring of positioning-error images using K-means clustering analysis is a valid evaluation indicator of correct patient positioning for technologists in training.
Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report
Authors: Qader Abdul Qadir , Akhgar Javid , Tan Stephanie Wai Yee , Abdul Hamid Hamzaini 
Published: January 2024

Abstract
Background
Although paediatric patients with acute lymphoblastic leukaemia (ALL) have improved survival following modern chemotherapy treatment, disease relapses still occur in 20–25% of them. Our case had relapsed ALL with testicular leukaemic infiltration, which is rare, with less than 2% incidence.

Case presentation
We describe a case of an 11-year-old boy with a background history of ALL presenting with painless unilateral scrotal swelling. An initial ultrasound of the testes showed heterogeneity throughout with hypervascularity on colour-flow imaging on the affected testis. Some areas are hypoechoic with dilated tubules. The histopathology of the follow-up testicular biopsy revealed malignant cells and leukaemic infiltration. Patient subsequently received chemotherapy treatment at another centre.

Conclusions
Testicular relapse of ALL is relatively rare with the use of improved contemporary frontline treatment with better outcomes. With its non-specific symptoms, radiological imaging can significantly facilitate timely diagnosis and contribute to appropriate further management and improved prognosis.
Artificial intelligence-based optimal EVCS integration with stochastically sized and distributed PVs in an RDNS segmented in zones
Authors: Rene Ebunle Akupan , Fokui Willy Stephen Tounsi 
Published: January 2024

AbstractThe growing interest in electric vehicles (EVs) for transportation has led to increased production and government support through legislation since they offer environmental benefits such as reduced air pollution and carbon emissions compared to conventional combustion engine vehicles. This shift toward EV technology aligns with the goal of preserving the natural environment. To fully utilize EVs, effective management of the power grid is crucial, particularly in radial distribution network systems (RDNS) as they pose stress and deviation of power system parameters from their normal. This study proposes a novel strategy for maximizing EV utilization through EV charging stations (EVCSs) in an RDNS by considering factors such as load voltage deviation, line losses, and the presence of distributed solar photovoltaic systems at load centers. The research begins by segmenting the RDNS into zones, followed by the application of an artificial intelligence-based hybrid genetic algorithm (GA) and particle swarm optimization (PSO) approach known as hybrid GA–PSO. This approach identifies optimal locations for EVCSs integrated with photovoltaics within the network. Subsequently, the employment of individual GA and PSO algorithms to optimize EVCS placement focuses on minimizing power loss and enhancing voltage. The effectiveness of the hybrid GA–PSO algorithm is compared to that of separate GA and PSO methods. Extensive simulations using the IEEE 33-node test feeders validate the proposed techniques, demonstrating the usefulness of the hybrid GA–PSO algorithm in identifying optimal EVCS placement within each zone. The results also highlight the advantages and novelty of hybrid GA–PSO in achieving optimal EVCS placement with stochastically sized and distributed photovoltaic in an RDNS.
A market definition paradigm equilibrium voltage analysis of ageing and temperature in lithium-ion cells
Authors: Enochoghene Samuel O. , Yesufu Thomas K. 
Published: January 2024

AbstractThis study was on the use of the market definition paradigm (MDP) to track ageing and temperature effects in lithium–ion cells. This was with a view to using the technique to obtain a sequence of equilibrium voltages from readily available datasets in order to profile the effects of ageing and temperature on cells and batteries. The method employed involved using the MDP with its capability to obtain a sequence of equilibrium voltages for lithium-ion cells. This approach integrated radio incidence with radio geometry, transmission and emergence in a simplified form of the cell’s equilibrium voltage (and amperage). A standard dataset was obtained from the centre for advanced life cycle engineering repository. The data were processed and analysed using Coulomb counting, charging and discharging energy comparison methods on Python 3.8 programming tool and LibreOffice spreadsheet software. Results obtained show a close tracking of ageing and temperature phenomena in the cells studied. A respective maximum and minimum equilibrium voltages of 3.23 V and 3.10 V over two thousand (2000) cycles were similarly obtained for ageing and temperature investigations. The equilibrium voltage shows a downward trend as the battery ages and is more reliable for studies on these cells than the open circuit voltage traditionally used to track phenomena in such cells. In conclusion, typical lithium-ion cells can be classified at begin-of-life using the equilibrium voltage and useful predictions made with respect to end-of-life. This approach is relatively inexpensive, requiring fewer data points and low-cost hardware and extensible to online applications.
Graphical Abstract
Comparative study between radiation exposure in common urological procedures
Authors: Elmarakbi Akrm A. , Elnoiry Ali Korany , Deiab Nashaat , Lotfy Amr M. 
Published: January 2024

Abstract
Background
Fluoroscopy has become essential to urological surgery since advancement of endourology. Fluoroscopy use has increased, placing urologists as well as staff members at risk for occupational radiation exposure and related dangers. This study compared radiation exposure for staff personnel in percutaneous nephrolithotomy (PCNL), ureteroscopy (URS) and extracorporeal shock wave lithotripsy (ESWL). Then, study determined the maximum number of PCNL, URS and ESWL cases that staff members can handle safely each year.

Results
Radiation exposure in PCNL group was higher than URS and ESWL especially for surgeon. Dose of radiation exposure in ESWL for surgeon, assistant and nurse was 2.4 microsievert (μSv), 0.9 μSv and 0.8 μSv, respectively. Dose of radiation exposure in URS for surgeon, assistant and nurse was 18.5 μSv, 14.3 μSv and 13.1 μSv, respectively. Dose of radiation exposure in PCNL for surgeon, assistant and nurse was 73 μSv, 51.3 μSv and 47.6 μSv, respectively.

Conclusion
Increased stone size and increased fluoroscopy time were associated with high radiation exposure. PCNL procedure was 8.8 times more likely to exhibit high-dose exposure than other procedures. Urologists can perform: 274 PCNL case, 1081 URS case and 8333 ESWL case per year within safe radiation exposure limits advised by International Commission on Radiation Protection (ICRP).
Correlation between neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with proteinuria in different stages of chronic kidney disease
Authors: Aneez Fathima Azra , Shariffdeen Nifla , Haleem Fathima Asra , Thangarajah Brammah R , Rasaratnam Karunaithas 
Published: January 2024

Abstract
Background
Chronic kidney disease (CKD) is a progressive failure of renal function with ongoing systemic inflammation. Inflammatory markers such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and proteinuria were documented as independent predictors of CKD progression. Although proteinuria estimated by the protein to creatinine ratio (UPCR) is generally employed to screen the disease progression of CKD, the correlation of NLR and PLR with different stages of CKD is yet to be studied. Consequently, this study strived to find the stage-wise correlation between NLR and PLR with proteinuria in CKD patients.

Methods
Eighty-five CKD patients with proteinuria who visited the Nephrology Clinic at Teaching Hospital Jaffna, Sri Lanka, were randomly selected and categorized as stages II to IV based on the estimated glomerular filtration rate (e-GFR). Blood samples were collected and subjected to investigate patients’ NLR and PLR. Furthermore, urine protein and creatinine were measured and UPCR was calculated. Participants’ demographic, clinical, and laboratory data were obtained from patients’ clinical registry. Spearman’s rank correlation and receiver operative characteristic (ROC) curve analysis was done, and the p value < 0.05 was considered statistically significant.

Results
Amongst the total participants, males were predominant (58.8%), with a mean age of 58.1. Severity analysis based on the e-GFR revealed that 17.64%, 18.82%, 29.41%, and 34.11% of CKD patients were in stages II, IIIA, IIIB, and IV, respectively. Stage-wise correlation and ROC curve analysis indicated that NLR and PLR were positively correlated with UPCR in stages IIIA, IIIB, and IV of CKD with more than 80% predictive sensitivity and specificity.

Conclusion
NLR and PLR can be used as novel predictive markers for monitoring the severity of CKD; however, further large-scale cohort studies of NLR and PLR with serial monitoring and multiple closely spaced measurements are recommended to develop these markers into clinically acceptable markers for CKD progression.
Exploring the relation between the central auditory processing functions and language development among Arabic-speaking children with attention deficit hyperactivity disorder
Authors: Hegazi Mona Abdel-Fattah , Khalil Ghada Moharram , Mohamed Sarah Mosaad , Khodeir Mona Sameeh 
Published: January 2024

Abstract
Background
Debate still exists on the effect of central auditory processing disorder (CAPD) on the language of children with attention deficit hyperactive disorder (ADHD). This study aimed to explore the deficits of the central auditory processing (CAP) functions and their relation to language development and ADHD symptoms in 30 Egyptian Arabic-speaking children with ADHD between 4 and ≤ 7 years old. ADHD symptoms were rated by Conners’ Parent Rating Scale–Revised. Language development was assessed by the Modified Pre-school Language Scale (PLS) 4th edition, the Arabic version, and the Egyptian Arabic Pragmatic Language Test. CAP functions were tested by the Pediatric Speech Intelligibility (PSI) test (Arabic version).

Results
Sixty percent of the ADHD children had comorbid CAPD with predominance among ADHD children of combined type. There was a significant positive correlation between all PSI subtests assessing the monotonic auditory closure and dichotic auditory separation abilities in both ears and the language ages by the modified PLS-4. There was also a significant positive correlation between scores of the Egyptian Arabic Pragmatic Language Test (EAPLT) and the monotonic auditory closure ability in both ears and auditory separation ability in the right ear only.There was a non-significant mild difference in scores of the modified PLS-4 in favor of the ADHD children with normal CAP functions.

Conclusion
Not all children with ADHD have central auditory processing disorder as both ADHD and CAPD are independent disorders. Better central auditory processing functions are associated with well-developed language and higher pragmatic skills in ADHD children.
Predictors of mortality in critically ill children hospitalized with laboratory- confirmed COVID-19 pneumonia
Authors: Elmeazawy Rehab , EL-Moazen Ahmed Mohammed Farid 
Published: January 2024

Abstract
Background
Children with COVID-19 infection had fewer severe symptoms, which made it challenging to publish clinical data for this age group. This study aimed to determine the clinical features, laboratory markers, and predictors of mortality in children hospitalized in Pediatric Critical Care Units with COVID-19 pneumonia.

Methods
This retrospective research included all children between the age of ≥ 1 month and 18 years with laboratory-confirmed COVID-19 pneumonia through reverse transcriptase polymerase chain reaction (RT-PCR) from nasopharyngeal swabs who were admitted to Pediatric Critical Care Units between January 2022 and December 2022.

Results
The study included 62 patients with confirmed COVID-19 infection. Out of the 62 patients, 43 (69.4%) survived and 19 (30.6%) succumbed. High-grade fever, cough, altered level of consciousness, convulsion, CO-RADS IV, elevated blood CRP, urea, D-dimer, ferritin, and sodium were linked to significantly higher mortality risk. (OR: 15.867, p = 0.001, OR: 1.543, p = 0.044, OR: 7.321, p = 0.026, OR: 15.00, p = 0.017, OR: 10.833, p = 0.001, OR: 1.015, p = 0.032, OR: 1.028, p = 0.040, OR: 3.315, p < 0.0001, OR: 1.004, p = 0.049, OR: 1.111, p = 0.006 respectively).

Conclusion
Our study revealed high in-hospital mortality among critically ill children with confirmed COVID-19 pneumonia. Identification of critically ill children with risk factors for death, such as high-grade fever, cough, altered consciousness, convulsion, CO-RADS IV and V, and raised inflammatory markers at the time of admission could minimize excess mortality during COVID-19 waves.
Development and validation of a promising 5-gene prognostic model for pediatric acute myeloid leukemia
Authors: Tao Yu , Wei Li , Shiba Norio , Tomizawa Daisuke , Hayashi Yasuhide , Ogawa Seishi , Chen Li , You Hua 
Published: January 2024

AbstractRisk classification in pediatric acute myeloid leukemia (P-AML) is crucial for personalizing treatments. Thus, we aimed to establish a risk-stratification tool for P-AML patients and eventually guide individual treatment. A total of 256 P-AML patients with accredited mRNA-seq data from the TARGET database were divided into training and internal validation datasets. A gene-expression-based prognostic score was constructed for overall survival (OS), by using univariate Cox analysis, LASSO regression analysis, Kaplan–Meier (K-M) survival, and multivariate Cox analysis. A P-AML-5G prognostic score bioinformatically derived from expression levels of 5 genes (ZNF775, RNFT1, CRNDE, COL23A1, and TTC38), clustered P-AML patients in training dataset into high-risk group (above optimal cut-off) with shorter OS, and low-risk group (below optimal cut-off) with longer OS (p < 0.0001). Meanwhile, similar results were obtained in internal validation dataset (p = 0.005), combination dataset (p < 0.001), two treatment sub-groups (p < 0.05), intermediate-risk group defined with the Children's Oncology Group (COG) (p < 0.05) and an external Japanese P-AML dataset (p = 0.005). The model was further validated in the COG study AAML1031(p = 0.001), and based on transcriptomic analysis of 943 pediatric patients and 70 normal bone marrow samples from this dataset, two genes in the model demonstrated significant differential expression between the groups [all log2(foldchange) > 3, p < 0.001]. Independent of other prognostic factors, the P-AML-5G groups presented the highest concordance-index values in training dataset, chemo-therapy only treatment subgroups of the training and internal validation datasets, and whole genome-sequencing subgroup of the combined dataset, outperforming two Children's Oncology Group (COG) risk stratification systems, 2022 European LeukemiaNet (ELN) risk classification tool and two leukemic stem cell expression-based models. The 5-gene prognostic model generated by a single assay can further refine the current COG risk stratification system that relies on numerous tests and may have the potential for the risk judgment and identification of the high-risk pediatric AML patients receiving chemo-therapy only treatment.
The epidemiology of notifiable diseases in Australia and the impact of the COVID-19 pandemic, 2012–2022
Authors: Sohail Asma , Cheng Allen C. , McGuinness Sarah L. , Leder Karin 
Published: January 2024

Abstract
Background
Infectious disease surveillance tracks disease epidemiology and informs prevention and control. Public health measures implemented in Australia during the COVID-19 pandemic (2020 to 2022) affected infectious disease epidemiology. We examined notifiable disease epidemiology in Australia from 2012 to 2022, evaluating disease trends and pandemic impacts.

Methods
We analysed case notifications supplied to the Australian National Notifiable Disease Surveillance System (NNDSS) from 1 January 2012 to 31 December 2022. The annual incidence and notification incidence trends were calculated and the average changes in annual incidence were investigated by Poisson regression.

Results
Over the study period, there were 14,087,045 notifications of 68 diseases. Respiratory diseases were the most commonly notified disease group (83% of all notifications) and vector-borne diseases the least (< 1%). The ten highest-incidence diseases comprised 97% of all notifications over the study period, with COVID-19 alone accounting for 72%. Notifications were most common among the 20–39-year age group (37%). From 2012–2019, notification incidence of gastrointestinal, respiratory and sexually transmissible infections increased, whereas for bloodborne viral hepatitis, vector-borne diseases and imported diseases it decreased. From 2020–2021, average notification incidence of most non-COVID-19 respiratory diseases decreased compared to the 2012–2019 period; sexually transmissible infections notification incidence remained fairly stable; notification incidence of some gastrointestinal diseases increased while others decreased; and notification of imported diseases markedly decreased. A rebound in notification incidence was seen for most diseases in 2022.

Conclusions
Prior to the COVID-19 pandemic, most notifiable diseases had increasing notification incidence, except for bloodborne viral hepatitis, vector-borne diseases and imported diseases. COVID-19-related public health measures had variable impacts on notifiable diseases.