bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical‐Radiologic Morphology‐Radiomics Model on Gadobenate Dimeglumine‐Enhanced MRI for Identification of Highly Aggressive Hepatocellular Carcinoma: Temporal Validation and Multiscanner Validation
Authors: Zheng Wanjing , Chen Xiaodan , Xiong Meilian , Zhang Yu , Song Yang , Cao Dairong 
Published: February 2024

BackgroundHighly aggressive hepatocellular carcinoma (HCC) is characterized by high tumor recurrence and poor outcomes, but its definition and imaging characteristics have not been clearly described.PurposeTo develop and validate a fusion model on gadobenate dimeglumine‐enhanced MRI for identifying highly aggressive HCC.Study TypeRetrospective.Population341 patients (M/F = 294/47) with surgically resected HCC, divided into a training cohort (n = 177), temporal validation cohort (n = 77), and multiscanner validation cohort (n = 87).Field Strength/Sequence3T, dynamic contrast‐enhanced MRI with T1‐weighted volumetric interpolated breath‐hold examination gradient‐echo sequences, especially arterial phase (AP) and hepatobiliary phase (HBP, 80–100 min).AssessmentClinical factors and diagnosis assessment based on radiologic morphology characteristics associated with highly aggressive HCCs were evaluated. The radiomics signatures were extracted from AP and HBP. Multivariable logistic regression was performed to construct clinical‐radiologic morphology (CR) model and clinical‐radiologic morphology‐radiomics (CRR) model. A nomogram based on the optimal model was established. Early recurrence‐free survival (RFS) was evaluated in actual groups and risk groups calculated by the nomogram.Statistical TestsThe performance was evaluated by receiver operating characteristic curve (ROC) analysis, calibration curves analysis, and decision curves. Early RFS was evaluated by using Kaplan–Meier analysis. A P value <0.05 was considered statistically significant.ResultsThe CRR model incorporating corona enhancement, cloud‐like hyperintensity on HBP, and radiomics signatures showed the highest diagnostic performance. The area under the curves (AUCs) of CRR were significantly higher than those of the CR model (AUC = 0.883 vs. 0.815, respectively, for the training cohort), 0.874 vs. 0.769 for temporal validation, and 0.892 vs. 0.792 for multiscanner validation. In both actual and risk groups, highly and low aggressive HCCs showed statistically significant differences in early recurrence.Data ConclusionThe clinical‐radiologic morphology‐radiomics model on gadobenate dimeglumine‐enhanced MRI has potential to identify highly aggressive HCCs and non‐invasively obtain prognostic information.Level of Evidence4Technical EfficacyStage 2
Diffusion‐Weighted MRI‐Based Virtual Elastography and Shear‐Wave Elastography for the Assessment of Breast Lesions
Authors: Sun Kun , Zhu Ying , Chai Weimin , Zhu Hong , Fu Caixia , Zhan Weiwei , Yan Fuhua 
Published: February 2024

BackgroundDiffusion‐weighted imaging (DWI)‐based virtual MR elastography (DWI‐vMRE) in the assessment of breast lesions is still in the research stage.PurposeTo investigate the usefulness of elasticity values on DWI‐vMRE in the evaluation of breast lesions, and the correlation with the values calculated from shear‐wave elastography (SWE).Study TypeProspective.Population/Subjects153 patients (mean age ± standard deviation: 55 ± 12 years) with 153 pathological confirmed breast lesions (24 benign and 129 malignant lesions).Field Strength/Sequence1.5‐T MRI, multi‐b readout segmented echo planar imaging (b‐values of 0, 200, 800, and 1000 sec/mm2).AssessmentFor DWI‐vMRE assessment, lesions were manually segmented using apparent diffusion coefficient (ADC0–1000) map, then the region of interests were copied to the map of shifted‐ADC (sADC200–800, sADC 200–1500). For SWE assessment, the shear modulus of the lesions was measured by US elastic modulus (μUSE). Intraclass/interclass kappa coefficients were calculated to measure the consistency.Statistical TestsPearson's correlation was used to assess the relationship between sADC and μUSE. A receiver operating characteristic analysis with the area under the curve (AUC) was performed to compare the diagnostic accuracy between benign and malignant breast lesions of sADC and μUSE. A P value <0.05 was considered statistically significant.ResultsThere were significant differences between benign and malignant breast lesions of μUSE (24.17 ± 10.64 vs. 37.20 ± 12.61), sADC200–800 (1.38 ± 0.31 vs. 0.97 ± 0.18 × 10−3 mm2/sec), and sADC200–1500 (1.14 ± 0.30 vs. 0.78 ± 0.13 × 10−3 mm2/sec). In all breast lesions, a moderate but significant correlation was observed between μUSE and sADC200–800/sADC200–1500 (r = −0.49/−0.44). AUC values to differentiate benign from malignant lesions were as follows: μUSE, 0.78; sADC200–800, 0.89; sADC200–1500, 0.89.Data ConclusionsBoth SWE and DWI‐vMRE could be used for the differentiation of benign versus malignant breast lesions. Furthermore, DWI‐vMRE with the use of sADC show relatively higher AUC values than SWE.Level of Evidence4Technical EfficacyStage 2
The evolutionary phylodynamics of human parechovirus A type 3 reveal multiple recombination events in South Korea
Authors: Truong Thoi C. , Park Heekuk , Kim Jong‐Hwa , Tran Van Trung , Kim Wonyong 
Published: February 2024

AbstractHuman parechovirus A (HPeV‐A) is a causative agent of respiratory and gastrointestinal illnesses, acute flaccid paralysis encephalitis, meningitis, and neonatal sepsis. To clarify the characteristics of HPeV‐A infection in children, 391 fecal specimens were collected from January 2014 to October 2015 from patients with acute gastroenteritis in Seoul, South Korea. Of these, 221/391 (56.5%) HPeV‐A positive samples were found in children less than 2 years old. Three HPeV‐A genotypes HPeV‐A1 (117/221; 52.94%), HPeV‐A3 (100/221; 45.25%), and HPeV‐A6 (4/221; 1.81%) were detected, among which HPeV‐A3 was predominant with the highest recorded value of 58.6% in 2015. Moreover, recombination events in the Korean HPeV‐A3 strains were detected. Phylogenetic analysis revealed that the capsid‐encoding regions and noncapsid gene 2A of the four Korean HPeV‐A3 strains are closely related to the HPeV‐A3 strains isolated in Canada in 2007 (Can82853‐01), Japan in 2008 (A308/99), and Taiwan in 2011 (TW‐03067‐2011) while noncapsid genes P2 (2B–2C) and P3 (3A–3D) are closely related to those of HPeV‐A1 strains BNI‐788St (Germany in 2008) and TW‐71594‐2010 (Taiwan in 2010). This first report on the whole‐genome analysis of HPeV‐A3 in Korea provides insight into the evolving status and pathogenesis of HPeVs in children.
The bay barnacle Amphibalanus improvisus (Darwin, 1854) in the Pleistocene of Europe? A review of Pleistocene Balanidae of northern Central Europe
Authors: Meng Stefan , Strahl Jaqueline , Börner Andreas , Krienke Kay , Zettler MICHAEL L. , Wrozyna Claudia 
Published: February 2024

ABSTRACTThe bay barnacle Amphibalanus improvisus (Darwin, 1854) has been found in Northern Germany in brackish marine sediments of the Holsteinian interglacial. Whereas the cause of the contemporary distribution of this species is anthropogenic and there is evidence that it has resulted mainly from shipping, the fossil findings demonstrate that A. improvisus had also already reached Europe naturally during the Pleistocene in Europe, probably via the Gulf Stream system of the Atlantic. Today, A. improvisus is considered one of the most successful aquatic invasive species worldwide and it is characterized by a high environmental tolerance. The ingression of the Holsteinian Sea, during the Pleistocene, took place during the climate optimum from the North Sea into the ‘Elbe Estuary’ through the Hamburg region and far to the south‐east into Brandenburg. It has been possible to reconstruct the palaeo‐ecological conditions based in particular on molluscs. Accordingly, environmental conditions ranged from normal marine in the north, via brackish in the transitional area to limnic–fluviatile in the Berlin region. The morphological features of the bay barnacles and their ecological parameters are described here in detail. In addition, we provide a general review of the known Pleistocene Balanidae in northern central Europe.
RhoGDIβ inhibition via miR‐200c/AUF1/SOX2/miR‐137 axis contributed to lncRNA MEG3 downregulation‐mediated malignant transformation of human bronchial epithelial cells
Authors: Yang Yichao , Tian Zhongxian , He Lijiong , Meng Hao , Xie Xiaomin , Yang Ziyi , Wang Xinxing , Zhao Yunping , Huang Chuanshu 
Published: February 2024

AbstractNickel pollution is a recognized factor contributing to lung cancer. Understanding the molecular mechanisms of its carcinogenic effects is crucial for lung cancer prevention and treatment. Our previous research identified the downregulation of a long noncoding RNA, maternally expressed gene 3 (MEG3), as a key factor in transforming human bronchial epithelial cells (HBECs) into malignant cells following nickel exposure. In our study, we found that deletion of MEG3 also reduced the expression of RhoGDIβ. Notably, artificially increasing RhoGDIβ levels counteracted the malignant transformation caused by MEG3 deletion in HBECs. This indicates that the reduction in RhoGDIβ contributes to the transformation of HBECs due to MEG3 deletion. Further exploration revealed that MEG3 downregulation led to enhanced c‐Jun activity, which in turn promoted miR‐200c transcription. High levels of miR‐200c subsequently increased the translation of AUF1 protein, stabilizing SOX2 messenger RNA (mRNA). This stabilization affected the regulation of miR‐137, SP‐1 protein translation, and the suppression of RhoGDIβ mRNA transcription and protein expression, leading to cell transformation. Our study underscores the co‐regulation of RhoGDIβ expression by long noncoding RNA MEG3, multiple microRNAs (miR‐200c and miR‐137), and RNA‐regulated transcription factors (c‐Jun, SOX2, and SP1). This intricate network of molecular events sheds light on the nature of lung tumorigenesis. These novel findings pave the way for developing targeted strategies for the prevention and treatment of human lung cancer based on the MEG3/RhoGDIβ pathway.
Predicting the credit risk of small and medium‐sized enterprises in supply chain finance using machine learning algorithms
Authors: Hou Liangliang , Lu Ke , Bi Gongbing 
Published: February 2024

AbstractThe credit risk of small and medium‐sized enterprises (SMEs) in supply chain finance (SCF) hinders the sustainability of the supply chain and threatens the monetary loss of SCF partners, that is, focal enterprises (FEs) and financial institutions (FIs). Thus, it is crucial to predict SMEs' credit risk accurately. However, redundant features and imbalanced sample data may decrease the accuracy of the prediction model. Therefore, a novel credit risk prediction framework is proposed called FS‐RS‐ML, which is short for Feature Selection–Resample Strategy–Machine Learning. In this approach, Recursive Feature Elimination with Cross‐Validation (RFECV) is applied to select key features influencing SMEs' credit risk prediction, and three resampling techniques are used to balance the sample data. Finally, five machine learning algorithms are adopted to classify high‐risk and low‐risk SMEs. The experiments based on Chinese SCF data demonstrate that the FS‐RS‐ML framework outperforms any single algorithm. Moreover, according to the analysis of empirical results, features derived from SMEs have the most important impact on credit risk prediction. And the effect of key features on predicting SMEs' credit risk is revealed.
Intercostal nerve transfer in management of biceps and triceps co‐contraction in brachial plexus birth palsy
Authors: Misra Sayantani , Takagi Takehiko , Yamaguchi Sakura , Anami Yoko , Takayama Shinichiro 
Published: February 2024

AbstractObjectiveBrachial plexus birth palsy (BPBP) is often caused by traction during birth. In some cases, reinnervation occurs during spontaneous recovery and it causes involuntary co‐contraction between antagonistic muscles. When it comes up between the biceps and triceps muscles, smooth active motion of the elbow joint is impaired. We are presenting outcomes of intercostal nerve (ICN) to radial nerve transfer to minimize elbow motion abnormality due to co‐contraction.MethodsWe present five cases (two males and three females) of biceps and triceps co‐contraction in BPBP patients treated from 2005 to 2018. The mean age at surgery was 9.36 years (range, 4.8–16.4 years). They were treated by ICNs transfer to motor branch of the radial nerve to the triceps muscle. Preoperative electromyography was done in all cases to confirm biceps and triceps co‐contraction and to assess the contractile status of both muscles. A 10‐s flexion extension test was done pre and postoperatively to assess the efficacy of our procedure.ResultsThe postop course was uneventful. No donor site morbidity or respiratory complications were recorded in any patient. The mean postoperative follow‐up period was 83.9 months (range, 53.6–135.5 months). At the final follow‐up, elbow flexion was M4 in the Medical Research Council (MRC) grading scale in all five patients and elbow extension was graded M4 or M4− in all five patients. There was significant increase in the 10 s flexion extension test results delineating the effectiveness of the procedure.ConclusionsICNs transfer to motor branch of the radial nerve to the triceps muscle for management of biceps and triceps co‐contraction in BPBP is a good option with minimal morbidity and good success rate.
Elucidating the causal landscape: Mendelian randomization analysis of lifestyle and physiological factors in stress urinary incontinence
Authors: Liu Qinggang , Wang Linna , Liao Limin , Cong Huiling , Gao Yi 
Published: February 2024

AbstractPurposeTo explore the potential causal links between obesity, type 2 diabetes (T2D), and lifestyle choices (such as smoking, alcohol and coffee consumption, and vigorous physical activity) on stress urinary incontinence (SUI), this study employs a Mendelian Randomization approach. This research aims to clarify these associations, which have been suggested but not conclusively established in prior observational studies.MethodsGenetic instruments associated with the exposures at the genome‐wide significance (p < 5 × 10−8) were selected from corresponding genome‐wide association studies. Summary‐level data for SUI, was obtained from the UK Biobank. A two‐sample MR analysis was employed to estimate causal effects, utilizing the inverse‐variance weighted (IVW) method as the primary analytical approach. Complementary sensitivity analyses including MR‐PRESSO, MR‐Egger, and weighted median methods were performed. The horizontal pleiotropy was detected by using MR‐Egger intercept and MR‐PRESSO methods, and the heterogeneity was assessed using Cochran's Q statistics.ResultsOur findings demonstrate a significant causal relationship between higher body mass index (BMI) and the risk of SUI, with increased abdominal adiposity (WHRadjBMI) similarly linked to SUI. Smoking initiation is also causally associated with an elevated risk. However, our analysis did not find definitive causal connections for other factors, including T2D, alcohol consumption, coffee intake, and vigorous physical activity.ConclusionsThese findings provide valuable insights for clinical strategies targeting SUI, suggesting a need for heightened awareness and potential intervention in individuals with higher BMI, WHR, and smoking habits. Further research is warranted to explore the complex interplay between genetic predisposition and lifestyle choices in the pathogenesis of SUI.
Core competencies for Registered Nurse preceptors: A mapping review of quantitative studies
Authors: Ryan Colleen L. , Cant Robyn , Hughes Lynda , Ahchay Darrelle , Strickland Karen 
Published: February 2024

AbstractAimsTo review the contemporary international literature on nurse preceptor competencies and map the components and their descriptors.Review MethodsA mapping review.Data SourcesArticles reporting evidence‐based and validated Registered Nurse (RN) preceptor competencies published between 2013 and 2022 were identified. Open access databases such as PubMed and Google Scholar and the library healthcare databases Scopus and CINAHL were searched. The authors collaborated at each review stage that included screening, article selection, tabulation, mapping and preparation of findings.ResultsSeven quantitative studies were included. Three were based on existing nurse preceptor competency data sets and four were purposely developed using collaborative research methods. Each study validated findings through a survey of nurse stakeholders. Three key competencies shared across all studies were ‘facilitating teaching’, ‘being a role model’ and ‘evaluating student's performance’. The number of competency categories ranged from three to 10 and the accompanying item descriptors from 9 to 83. Although terminology describing data sets was inconsistent, similarity was seen across competency domains.ConclusionThe contemporary nursing preceptor role is considered an emerging specialist education role. The results offer a set of validated preceptor competency descriptors, applicable to practice, that provide insight into ways employers may recruit, support and retain nurse preceptors.Implications for the ProfessionThe mapped results provide a concise summary of nurse preceptor competency research internationally that can inform further development of RN preceptors.ImpactThis review addresses the lack of consensus around nursing preceptor competencies for clinical supervision of undergraduate nursing students.Seven competency domains were identified describing key preceptor role capabilities. The domains Facilitator’, ‘Role model’ and ‘Evaluator’ featured across the included studies: ‘More than 300 competency descriptors were reported’.Our review results could better prepare RN preceptors for their important role. Employers of RN preceptors could use the results to design performance competencies that may enhance nursing preceptorship.Reporting MethodThis review adheres to the PRISMA‐ScR EQUATOR guidelines as the recommended reporting method for mapping reviews.
Investigation on interlayer debonding behavior of unidirectional composite laminates under cyclical hygrothermal aging duration effects
Authors: Zhang Shengping , Hu Junshan , Fang Jinrong , Xuan Shanyong , Zhou Jian , Tian Wei 
Published: February 2024

AbstractThe composite interlamination is the key part of load transfer and plays a decisive role in the overall mechanical performance of composite structures. The interlaminar property is predominantly influenced by the matrix resin which is easily affected by the hygrothermal environment. This paper delved into the effect of hygrothermal aging duration on the interlayer debonding behavior of unidirectional (UD) laminates. The pre‐cracked specimens were treated by hygrothermal aging with a period of 0, 15, 30, 60, 90, and 120 days. The double cantilever beam (DCB) tests were employed to evaluate the interlaminar property. The effect of hygrothermal aging on load–displacement responses, R‐curves, crack growth speed, and fracture surface topography was analyzed. The results revealed that the load‐bearing capacity of aged specimens presented a reduction of 18.6%–29.0% compared with unaged ones. The interlaminar fracture toughness of specimens subjected to 15 days of treatment decreased significantly compared with that of unaged specimens due to the increase of water absorption caused by hygrothermal aging. With the increase in hygrothermal aging time, the interlaminar fracture toughness peaked at 60 days because of the post‐curing effect, followed by a declining trend influenced by the dominant hygrothermal aging effect. The fiber bridging of aged samples was increasingly obvious, became the most prominent at 60 days, and then gradually reduced. The fiber bridging diminished the crack propagation speed, hindered interlaminar debonding, and contributed to the interlaminar toughening.Highlights
The samples underwent hygrothermal aging for 0, 15, 30, 60, 90, and 120 days.
Load ability of aged samples was at least 18.6% lower than that of unaged ones.
R‐curves rose before the crack length of 79 mm and then tended to stabilize.
Fracture toughness first decreased, then increased and reduced with aging time.
Fiber bridging could hinder crack growth and improve the interlayer property.
A parametric study on patch repaired quasi‐isotropic laminate in high‐velocity impact environment: Experimental and numerical investigation
Authors: Sahoo Chinmaya Kumar , Chennamsetti Ramadas , Arockiarajan A. 
Published: February 2024

AbstractIn this work, the post‐repair behavior of a quasi‐isotropic laminate was studied in a high‐velocity impact environment. The composite laminates were repaired using an external bonded patch repair procedure. Impact tests were performed to understand the effect of patch size and the result of filling the damaged region with a neat epoxy and hardener mixture. Two different size square patches, such as 30 and 50 mm, were used to analyze the effect of patch size. A continuum damage mechanics‐based model was developed and incorporated into a finite element model interface to estimate the optimum patch size and patch stacking sequence for the impact environment. In the finite element model, the intralaminar failure criteria were implemented using the ABAQUS‐VUMAT user subroutine, and the interlaminar failure criteria were implemented using the inbuilt cohesive contact properties. The 30 mm patch with resin filled in the damaged region performed better than the other combination patches. Also, placing 45° plies toward the outer layer of the patches showed lower damage compared to the patches in which 45° plies were placed at the inner surfaces.Highlights
Post‐repair impact behavior of repaired laminates was examined.
Impact of patch dimension and resin filling in the damaged area was analyzed.
A 3‐D finite element model was developed to optimize patch parameters.
Continuum damage mechanics model has been incorporated with VUMAT subroutine.
Interface between lamina has been modeled using cohesive contact.
Die Suche nach kalten, fremden Welten
Authors: Hundertmark Markus , Tsapras Yiannis 
Published: February 2024

ZusammenfassungMehr als 100 Jahre nach Einsteins allgemeiner Relativitätstheorie belegt die gravitative Lichtablenkung beim Mikrolinseneffekt in unserer Milchstraße, dass jeder Stern im Schnitt mindestens einen Planeten aufweist. Damit lassen sich massearme Planeten jenseits der Schneelinie entdecken sowie isolierte Schwarze Löcher und ungebundene, freie Planeten. Mit großer Vorfreude werden zwei spannende neue Instrumente erwartet, die die Mikrolinsenastronomie auf eine breitere statistische Basis stellen werden. Das Nancy Grace Roman Space Telescope und das Simonyi Survey Teleskop am Vera C. Rubin Observatory werden komplementär hochgenau kurze, stellare Mikrolinsenereignisse sowie lange Ereignisse von Linsen am Endzustand ihrer Sternentwicklung beobachten. Das goldene Zeitalter der Mikrolinsenmethode liegt damit in der unmittelbaren Zukunft.