bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cretaceous planktonic foraminiferal biostratigraphy of the Umbria–Marche Basin (Central Italy)
Authors: Coccioni Rodolfo , Frontalini Fabrizio 
Published: January 2024

Abstract
The Umbria–Marche Basin of central Italy includes some of the most studied, continuous and well-exposed sequences of Cretaceous pelagic sediments known from the Tethyan Realm. A complete and well-preserved Cretaceous pelagic composite succession of this area is here presented. It has been constructed through the integration of the well-established magnetostratigraphy with the planktonic foraminiferal biostratigraphy based on previous and newly identified events from six key sections and one drill core. The recovery of planktonic foraminifera successfully disaggregated from the hard lithologies allows the identification and precise placement of several primary and secondary bioevents. In particular, the record of the identified bioevents counts 35 primary biohorizons, which allow the subdivision of the studied succession into 34 zones and 4 subzones. Following this study and previous findings on Cretaceous planktonic foraminifera, an updated planktonic foraminiferal zonation for the Cretaceous Period is proposed. This refined magnetobiostratigraphical framework, which in this study is integrated with the Cretaceous inoceramid, anoxic and carbon-isotope events recognized in the Umbria–Marche Basin, may provide an invaluable tool for improving Cretaceous correlations at low to middle latitudes, as well as palaeoenvironmental, palaeoclimatic and palaeoceanographical interpretations.
UNCAN.eu: Toward a European Federated Cancer Research Data Hub
Authors: Boutros Michael , Baumann Michael , Bigas Anna , Chaabane Linda , Guérin Julien , Habermann Jens K. , Jobard Aurélien , Pelicci Pier Giuseppe , Stegle Oliver , Tonon Giovanni , Valencia Alfonso , Winkler Eva C. , Blanc Patricia , De Maria Ruggero , Medema Rene H. , Nagy Peter , Tabernero Josep , Solary Eric 
Published: January 2024

Summary:
To enable a collective effort that generates a new level of UNderstanding CANcer (UNCAN.eu) [Cancer Discov (2022) 12 (11): OF1], the European Union supports the creation of a sustainable platform that connects cancer research across Member States. A workshop hosted in Heidelberg gathered European cancer experts to identify ongoing initiatives that may contribute to building this platform and discuss the governance and long-term evolution of a European Federated Cancer Data Hub.
ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension
Authors: Bian Jin-Song , Chen Jingyu , Zhang Junting , Tan Jianxin , Chen Yuan , Yang Xusheng , Li Yiying , Deng Lin , Chen Rongchang , Nie Xiaowei 
Published: January 2024

BACKGROUND:
Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression of pulmonary hypertension (PH). ErbB3 (human epidermal growth factor receptor 3), also recognized as HER3, is a member of the ErbB family of receptor tyrosine kinases.

METHODS:
Microarray, immunofluorescence, and Western blotting analyses were conducted to investigate the pathological role of ErbB3. Blood samples were collected for biomarker examination from healthy donors or patients with hypoxic PH. The pathological functions of ErbB3 were further validated in rodents subjected to chronic hypoxia- and Sugen-induced PH, with or without adeno-associated virus-mediated ErbB3 overexpression, systemic deletion, or endothelial cell–specific ErbB3 knockdown. Primary human pulmonary artery endothelial cells and pulmonary artery smooth muscle cells were used to elucidate the underlying mechanisms.

RESULTS:
ErbB3 exhibited significant upregulation in the serum, lungs, distal pulmonary arteries, and pulmonary artery endothelial cells isolated from patients with PH compared with those from healthy donors. ErbB3 overexpression stimulated hypoxia-induced endothelial cell proliferation, exacerbated pulmonary artery remodeling, elevated systolic pressure in the right ventricle, and promoted right ventricular hypertrophy in murine models of PH. Conversely, systemic deletion or endothelial cell–specific knockout of ErbB3 yielded opposite effects. Coimmunoprecipitation and proteomic analysis identified YB-1 (Y-box binding protein 1) as a downstream target of ErbB3. ErbB3 induced nuclear translocation of YB-1 and subsequently promoted hypoxia-inducible factor 1/2α transcription. A positive loop involving ErbB3-periostin-hypoxia–inducible factor 1/2α was identified to mediate the progressive development of this disease. MM-121, a human anti-ErbB3 monoclonal antibody, exhibited both preventive and therapeutic effects against hypoxia-induced PH.

CONCLUSIONS:
Our study reveals, for the first time, that ErbB3 serves as a novel biomarker and a promising target for the treatment of PH.
Endovascular Therapy for Basilar Artery Occlusion in Sudden Onset to Maximal Deficit Ischemic Events
Authors: Zhu Lina , Liu Wenhua , Hu Zhizhou , Li Zhenguang , Duan Zhenhui , Guo Zhangbao , Huang Fang , Lv Kefeng , Liao Jiasheng , Chen Zhao , Jiang He , Wang Kuiyun , Wang Hongjun , Lei Yang , Liao Jiachuan , Li Jing , Wang Mengmeng , Yuan Haicheng , Zi Wenjie , Wan Yue , Wang Pengfei 
Published: January 2024

Background
The presence of sudden onset to maximal deficit (SOTMD) in patients with acute basilar artery occlusion often results in more severe outcomes. However, the effect of endovascular therapy on SOTMD and whether the outcome is affected by onset‐to‐puncture time remain unclear.

Methods and Results

This retrospective analysis was conducted using data from the prospective BASILAR (Endovascular Treatment for Acute Basilar Artery Occlusion Study Registry). Consecutive patients with basilar artery occlusion receiving endovascular therapy were dichotomized into SOTMD and non‐SOTMD cohorts. The primary outcomes included a favorable outcome (modified Rankin scale 0–3), recanalization, and mortality at 90 days. The outcomes of patients with SOTMD were analyzed using multivariable logistic regression. In the multivariate analysis, a favorable outcome was similar between the two cohorts (odds ratio [OR], 0.88 [95% CI, 0.58–1.34];
P
=0.5), although the mortality of patients with SOTMD was higher than that of patients with non‐SOTMD (OR, 1.67 [95% CI, 1.14–2.44];
P
=0.008). The probability of mortality increased from 40.0% at 1 hour to 70.0% at 6 hours in the SOTMD cohort, and favorable outcomes of patients with non‐SOTMD declined from 38.0% at 1 hour to 18.0% at 8 hours.

Conclusions
No significant difference was observed in favorable outcomes between the SOTMD and non‐SOTMD groups, although mortality was higher in the SOTMD cohort. The patients with SOTMD had a stronger time dependence for endovascular therapy in terms of mortality, while the time dependency regarding favorable outcome in the NSOTMD group was even higher.

Registration

URL:
https://www.chictr.org.cn
; Unique identifier: ChiCTR1800014759.
Intravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials
Authors: Sreenivasan Jayakumar , Reddy Rohin K. , Jamil Yasser , Malik Aaqib , Chamie Daniel , Howard James P. , Nanna Michael G. , Mintz Gary S. , Maehara Akiko , Ali Ziad A. , Moses Jeffrey W. , Chen Shao‐Liang , Chieffo Alaide , Colombo Antonio , Leon Martin B. , Lansky Alexandra J. , Ahmad Yousif 
Published: January 2024

Background
Despite the initial evidence supporting the utility of intravascular imaging to guide percutaneous coronary intervention (PCI), adoption remains low. Recent new trial data have become available. An updated study‐level meta‐analysis comparing intravascular imaging to angiography to guide PCI was performed. This study aimed to evaluate the clinical outcomes of intravascular imaging–guided PCI compared with angiography‐guided PCI.

Methods and Results

A random‐effects meta‐analysis was performed on the basis of the intention‐to‐treat principle. The primary outcomes were major adverse cardiac events, cardiac death, and all‐cause death. Mixed‐effects meta‐regression was performed to investigate the impact of complex PCI on the primary outcomes. A total of 16 trials with 7814 patients were included. The weighted mean follow‐up duration was 28.8 months. Intravascular imaging led to a lower risk of major adverse cardiac events (relative risk [RR], 0.67 [95% CI, 0.55–0.82];
P
<0.001), cardiac death (RR, 0.49 [95% CI, 0.34–0.71];
P
<0.001), stent thrombosis (RR, 0.63 [95% CI, 0.40–0.99];
P
=0.046), target‐lesion revascularization (RR, 0.67 [95% CI, 0.49–0.91];
P
=0.01), and target‐vessel revascularization (RR, 0.60 [95% CI, 0.45–0.80];
P
<0.001). In complex lesion subsets, the point estimate for imaging‐guided PCI compared with angiography‐guided PCI for all‐cause death was a RR of 0.75 (95% CI, 0.55–1.02;
P
=0.07).

Conclusions
In patients undergoing PCI, intravascular imaging is associated with reductions in major adverse cardiac events, cardiac death, stent thrombosis, target‐lesion revascularization, and target‐vessel revascularization. The magnitude of benefit is large and consistent across all included studies. There may also be benefits in all‐cause death, particularly in complex lesion subsets. These results support the use of intravascular imaging as standard of care and updates of clinical guidelines.
Acute Coronary Syndrome Subphenotypes Based on Repeated Biomarker Measurements in Relation to Long‐Term Mortality Risk
Authors: de Bakker Marie , Scholte Niels T. B. , Oemrawsingh Rohit M. , Umans Victor A. , Kietselaer Bas , Schotborgh Carl , Ronner Eelko , Lenderink Timo , Aksoy Ismail , van der Harst Pim , Asselbergs Folkert W. , Maas Arthur , Oude Ophuis Anton J. , Krenning Boudewijn , de Winter Robbert J. , The S. Hong Kie , Wardeh Alexander J. , Hermans Walter , Cramer G. Etienne , van Schaik Ron H. , de Rijke Yolanda B. , Akkerhuis K. Martijn , Kardys Isabella , Boersma Eric , Akkerhuis K Martijn , de Bakker Marie , Boersma Eric , Kardys Isabella , de Rijke Yolanda B. , van Schaik Ron H. , Scholte Niels T.B. , Aksoy Ismail , Asselbergs Folkert W , Cramer G Etienne , van der Harst Pim , Hermans Walter , The S Hong Kie , Kietselaer Bas , Krenning Boudewijn , Gasthuis Franciscus , Lenderink Timo , Maas Arthur , Oemrawsingh Rohit M. , Oude Ophuis Anton J. , Ronner Eelko , Schotborgh Carl , Umans Victor A. , Wardeh Alexander J. , de Winter Robbert J. 
Published: January 2024

Background
We aimed to identify patients with subphenotypes of postacute coronary syndrome (ACS) using repeated measurements of high‐sensitivity cardiac troponin T, N‐terminal pro‐B‐type natriuretic peptide, high‐sensitivity C‐reactive protein, and growth differentiation factor 15 in the year after the index admission, and to investigate their association with long‐term mortality risk.

Methods and Results

BIOMArCS (BIOMarker Study to Identify the Acute Risk of a Coronary Syndrome) was an observational study of patients with ACS, who underwent high‐frequency blood sampling for 1 year. Biomarkers were measured in a median of 16 repeated samples per individual. Cluster analysis was performed to identify biomarker‐based subphenotypes in 723 patients without a repeat ACS in the first year. Patients with a repeat ACS (N=36) were considered a separate cluster. Differences in all‐cause death were evaluated using accelerated failure time models (median follow‐up, 9.1 years; 141 deaths). Three biomarker‐based clusters were identified: cluster 1 showed low and stable biomarker concentrations, cluster 2 had elevated concentrations that subsequently decreased, and cluster 3 showed persistently elevated concentrations. The temporal biomarker patterns of patients in cluster 3 were similar to those with a repeat ACS during the first year. Clusters 1 and 2 had a similar and favorable long‐term mortality risk. Cluster 3 had the highest mortality risk. The adjusted survival time ratio was 0.64 (95% CI, 0.44–0.93;
P
=0.018) compared with cluster 1, and 0.71 (95% CI, 0.39–1.32;
P
=0.281) compared with patients with a repeat ACS.

Conclusions
Patients with subphenotypes of post‐ACS with different all‐cause mortality risks during long‐term follow‐up can be identified on the basis of repeatedly measured cardiovascular biomarkers. Patients with persistently elevated biomarkers have the worst outcomes, regardless of whether they experienced a repeat ACS in the first year.
Association of Segment‐Specific Pulse Wave Velocity With Vascular Calcification: The ARIC (Atherosclerosis Risk in Communities) Study
Authors: Ejiri Kentaro , Ding Ning , Kim Esther , Honda Yasuyuki , Cainzos‐Achirica Miguel , Tanaka Hirofumi , Howard‐Claudio Candace M. , Butler Kenneth R. , Hughes Timothy M. , Van't Hof Jeremy R. , Meyer Michelle L. , Blaha Michael J. , Matsushita Kunihiro 
Published: January 2024

Background
Pulse wave velocity (PWV) is a noninvasive measure of arterial stiffness and predictor of cardiovascular disease. However, the association between PWV and vascular calcification across different vascular beds has not been fully investigated. This study aimed to quantify the association between PWV and multiterritory calcification and to explore whether PWV can identify individuals with vascular calcification beyond traditional risk factors.

Methods and Results
Among 1351 older adults (mean age, 79.2 years [SD, 4.1]) from the ARIC (Atherosclerosis Risk in Communities) study, we measured segment‐specific PWVs: heart–carotid, heart–femoral, carotid–femoral, heart–ankle, brachial–ankle, and femoral–ankle. Dependent variables were high calcium score (≥75th percentile of Agatston score) across different vascular beds: coronary arteries, aortic valve ring, aortic valve, mitral valve, ascending aorta, and descending aorta. Quartiles of carotid–femoral, heart–femoral, heart–ankle, and brachial–ankle PWV were significantly associated with coronary artery calcium (eg, adjusted odds ratio [OR] for the highest versus lowest quartile of carotid–femoral PWV, 1.84 [95% CI, 1.24–2.74]). Overall, PWVs were most strongly associated with descending aorta calcification, with significant results for carotid–femoral, heart–femoral, heart–ankle, and brachial–ankle PWV (eg, adjusted OR for the highest versus lowest quartile of carotid–femoral PWV, 3.99 [95% CI, 2.61–6.17]). In contrast, femoral–ankle PWV was inversely associated with descending aorta calcification. Some PWVs improved the discrimination of coronary artery calcium and descending aorta calcification beyond traditional risk factors.

Conclusions
The associations of PWV with vascular calcification varied substantially across segments, with descending aorta calcification most closely linked to PWVs. Our study suggests that some PWVs, especially carotid–femoral PWV, are helpful to identify individuals with coronary artery calcium and descending aorta calcification.
Infection, Inflammation, and Poststroke Cognitive Impairment
Authors: Milosevich Elise , Demeyere Nele , Pendlebury Sarah T. 
Published: January 2024

Background
Infection and inflammation are dementia risk factors in population‐based cohorts; however, studies in stroke are scarce. We determined the prevalence of infection after stroke and routinely measured inflammatory biomarkers during hospitalization and their associations with acute and 6‐month cognitive impairment.

Methods and Results

A prospective stroke cohort completed the Oxford Cognitive Screen at ≤2 weeks and 6 months after stroke. Infection, inflammatory markers (C‐reactive protein, white cell count, and neutrophil/lymphocyte ratio), and systemic inflammatory response syndrome were ascertained throughout admission with electronic patient records supplemented by hand searches. Associations with acute and 6‐month global and domain‐specific cognitive impairment were analyzed using multivariable regression, adjusting for demographic/vascular factors and stroke severity. Among 255 patients (mean age, 73.9 [SD, 12.6] years; 46.3% women; mean education, 12.6 [SD, 3.7] years; median National Institutes of Health Stroke Scale score 5 [range, minimum‐maximum, 0–30]), infection was present in 90 patients (35.3%) at mean 4.4 (SD, 6.9) days after stroke, consisting predominantly of pneumonia (47/90; 52%) and urinary tract infection (39/90; 43%). Admission white cell count was elevated in 25.1% (n=64; mean, 9.5×10
9
/L [SD, 3.2×10
9
/L]), C‐reactive protein in 41.2% (n=105; mean, 27.5 [SD, 50.9 mg/L]), neutrophil/lymphocyte ratio in 55.7% (n=97; mean, 5.5 [SD, 4.5]), and systemic inflammatory response syndrome in 26.6% (n=53 [45.2%] positive during hospitalization). Infection was associated with acute and 6‐month poststroke cognitive impairment (
P
<0.05
adj
) with stronger associations acutely for severe infection (infection+systemic inflammatory response syndrome;
P
=0.03
adj
). Acute language, executive function and attention domain impairments, and 6‐month number processing impairment were associated with infection (
P
<0.05
adj
). No significant relationships were found for any biomarker and cognitive impairment.

Conclusions
Infection and elevations in routinely measured inflammatory biomarkers are common following stroke; however, only infection is associated with poststroke cognitive impairment, suggesting that increases in these biomarkers may be nonspecific. Infection may present a tractable target for reducing poststroke cognitive impairment.
Future Changes in the Intensity and Duration of Marine Heat and Cold Waves: Insights from Coupled Model Initial-Condition Large Ensembles
Authors: Deser Clara , Phillips Adam S. , Alexander Michael. A. , Amaya Dillon J. , Capotondi Antonietta , Jacox Michael G. , Scott James D. 
Published: January 2024

Abstract
The future evolution of sea surface temperature (SST) extremes is of great concern, not only for the health of marine ecosystems and sustainability of commercial fisheries, but also for precipitation extremes fueled by moisture evaporated from the ocean. This study examines the projected influence of anthropogenic climate change on the intensity and duration of monthly SST extremes, hereafter termed marine heat waves (MHWs) and marine cold waves (MCWs), based on initial-condition large ensembles with seven Earth system models. The large number of simulations (30–100) with each model allows for robust quantification of future changes in both the mean state and variability in each model. In general, models indicate that future changes in variability will cause MHW and MCW events to intensify in the northern extratropics and weaken in the tropics and Southern Ocean, and to shorten in duration in many areas. These changes are generally symmetric between MHWs and MCWs, except for the longitude of duration change in the tropical Pacific and sign of duration change in the Arctic. Projected changes in ENSO account for a large fraction of the variability-induced changes in MHW and MCW characteristics in each model and are responsible for much of the intermodel spread as a result of differences in future ENSO behavior. The variability-related changes in MHW and MCW characteristics noted above are superimposed upon large mean-state changes. Indeed, their contribution to the total change in SST during MHW and MCW events is generally <10% except in polar regions where they contribute upward of 50%.
Seasonality, Latitudinal Dependence, and Structural Evolution of Arctic Cyclones
Authors: Yang Mingshi , Wang Zhuo , Rauber Robert M. , Walsh John E. 
Published: January 2024

Abstract
Arctic cyclones (ACs) are an important component of the Arctic climate system. While previous studies focused on case studies or samples of intense ACs, an AC tracking algorithm is applied here to ERA5 to provide more than 9300 tracks. This large sample enables evaluations of seasonality, latitudinal dependence, and the structural evolution of ACs using storm-centered composite analysis and phase space analysis. The structures of ACs of different genesis regions, polar versus midlatitude, are also examined and compared. The results show that ACs typically have an asymmetric horizontal structure with cold air to the west and warm air to the east of the cyclone center. Cyclone asymmetry decreases, and the circulation becomes more barotropic in higher latitudes. ACs of polar origin are more symmetric than ACs of midlatitude origin and dominate the cyclone occurrences over the Arctic Ocean. Regarding seasonality, winter ACs are more intense and have a stronger horizontal asymmetry, and the cyclonic circulation extends higher into the stratosphere than summer ACs. In contrast, summer ACs have stronger warm anomalies in the lower stratosphere associated with subsidence above the cyclone center, and the cyclonic circulation typically does not extend beyond 50 hPa. The latitudinal and seasonal variations of AC structure are consistent with the latitudinal and seasonal differences in environmental baroclinicity. Additionally, our analyses show that the structural evolution of ACs is characterized by reduced vertical tilt and asymmetry, weakened temperature contrast between west and east sectors in troposphere, and reduced updraft strength in the later stage of the AC life cycle.

Significance Statement
Arctic cyclones play a crucial role in climate projections and risk assessments for Arctic infrastructure, transportation, and other human activities. This study aims to enhance our understanding of Arctic cyclone characteristics, including their origin, structure, seasonality, and evolution. We discovered that Arctic cyclones exhibit various structures in different environments. Their degrees of symmetry, vertical tilts, temperature contrasts, and updraft strengths vary with season, latitude, and life cycle stage.
Association Between Serum Uric Acid and Abdominal Aortic Calcification in Adults Aged 40 to 80 years: A Retrospective Cross-Sectional Study
Authors: Hu Sheng , Qiu Shengyu , Wan Bingen , Ruan Liancheng , Zhu Lingxiao , Wang Siling , Su Lang , Guo Qiang , Xu Jianjun , Wei Yiping 
Published: January 2024

There are numerous causes of abdominal aortic calcification (AAC), among which the relationship between serum uric acid and AAC still needs to be investigated further. The aim of this research was to ascertain whether serum uric acid is correlated with AAC. Our study included 3007 participants. We described the study population characteristics and utilized univariate analysis, stratified analysis, multiple equation regression analysis, smoothed curve fitting, and threshold effects analysis. AAC Total 24 score is used to reflect the range of aortic calcification at each vertebral level. As serum uric acid increased, the AAC Total 24 score first decreased and then increased. The fold point is located when serum uric is at 3.5 mg/dL. After adjusting for 16 covariates, the beta values for the groups with moderate and high serum uric acid levels were 0.34 and 0.53, respectively, compared with the low serum uric acid tertile group ( P < .05). Our research indicates a negative correlation between serum acid level and AAC when serum uric acid <3.5 mg/dl, but it is positively correlated with the formation of AAC when serum uric acid >3.5 mg/dl.