bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catheter–tissue contact optimizes pulsed electric field ablation with a large area focal catheter
Authors: Doshi Shephal K. , Flaherty Mary Clare , Laughner Jacob , Quan Melinda , Anic Ante 
Published: February 2024

AbstractIntroductionPulsed electric field (PEF) ablation relies on the intersection of a critical voltage gradient with tissue to cause cell death. Field‐based lesion formation with PEF technologies may still depend on catheter–tissue contact (CTC). The purpose of this study was to assess the impact of CTC on PEF lesion formation with an investigational large area focal (LAF) catheter in a preclinical model.MethodsPEF ablation via a 10‐spline LAF catheter was used to create discrete right ventricle (RV) lesions and atrial lesion sets in 10 swine (eight acute, two chronic). Local impedance (LI) was used to assess CTC. Lesions were assigned to three cohorts using LI above baseline: no tissue contact (NTC: ≤∆10 Ω, close proximity to tissue), low tissue contact (LTC: ∆11–29 Ω), and high tissue contact (HTC: ≥∆30 Ω). Acute animals were infused with triphenyl tetrazolium chloride (TTC) and killed ≥2 h post‐treatment. Chronic animals were remapped 30 days post‐index procedure and stained with infused TTC.ResultsMean (± SD) RV treatment sizes between LTC (n = 14) and HTC (n = 17) lesions were not significantly different (depth: 5.65 ± 1.96 vs. 5.68 ± 2.05 mm, p = .999; width: 15.68 ± 5.22 vs. 16.98 ± 4.45 mm, p = .737), while mean treatment size for NTC lesions (n = 6) was significantly smaller (1.67 ± 1.16 mm depth, 5.97 ± 4.48 mm width, p < .05). For atrial lesion sets, acute and chronic conduction block were achieved with both LTC (N = 7) and HTC (N = 6), and NTC resulted in gaps.ConclusionsPEF ablation with a specialized LAF catheter in a swine model is dependent on CTC. LI as an indicator of CTC may aid in the creation of consistent transmural lesions in PEF ablation.
Atractylodes macrocephalaIII suppresses EMT in cervical cancer by regulating IGF2BP3 through ETV5
Authors: Wang Meixia , Meng Jingwen , Wang Hongyun , Hu Huijuan , Hong Ying 
Published: February 2024

AbstractAtractylodes macrocephala III (ATL III), with anti‐inflammatory and antitumor effects, is the main compound of Atractylodes macrocephala. Whether ATL III has an effect on cervical cancer and the specific mechanism are still unclear. Here, we investigated the effects of ATL III on cervical cancer cells at different concentrations and found that ATL III downregulates insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3), which was found to be highly expressed in cervical cancer tissue by RNA‐Seq. In this study, we found that ATL III promotes apoptosis and regulates epithelial–mesenchymal transition (EMT) in cervical cancer cells (HeLa and SiHa cells) and that IGF2BP3 is a common target gene of ATL III in HeLa and SiHa cells. The expression level of IGF2BP3 in cervical cancer cells was proportional to their migration and invasion abilities. This was verified by transfection of cells with a small interfering RNA and an IGF2BP3 overexpression plasmid. After ATL III treatment, the migration and invasion abilities of cervical cancer cells were obviously reduced, but these effects were attenuated after overexpression of IGF2BP3. In addition, the transcription factor IGF2BP3 was predicted by the JASPAR system. After intersection with our sequencing results, we verified the promotional effect of ETV5 (ETS translocation variant 5) on IGF2BP3 and found that ALT III inhibited ETV5. In general, our research showed that ATL III inhibits the migration and invasion of cervical cancer cells by regulating IGF2BP3 through ETV5.
Improved patient‐ and caregiver‐reported outcomes distinguish tacrolimus 0.03% from crisaborole in children with atopic dermatitis
Authors: Ryan Wolf Julie , Chen Anita , Wieser Jill , Johnson Brad , Baughman Lauren , Lee Gayin , Pope Eleanor , Franco Abigail , Love Tanzy , Beck Lisa A. 
Published: February 2024

AbstractBackgroundAtopic dermatitis (AD) is a chronic skin disease that affects 20% of children worldwide and is associated with low patient‐reported quality of life (QoL). Crisaborole (CRIS) and tacrolimus 0.03% (TAC) are Food and Drug Administration (FDA)‐approved topical treatments for mild to moderate AD with similar clinical efficacy. Utilization of patient‐reported outcomes (PROs) may provide meaningful data on the impact of AD treatments on patients and caregivers. This study used PROs to monitor the impact of crisaborole (CRIS) and tacrolimus 0.03% (TAC) on children with mild/moderate atopic dermatitis (AD) and caregiver burden.MethodsThis open‐label study randomized 47 child‐caregiver dyads to CRIS or TAC for 12 weeks. Disease severity, child quality of life (QoL), itch, pain interference, anxiety, depression, sleep, caregiver burden and caregiver QoL were assessed at baseline, 6 and 12 weeks.ResultsA total of 36 dyads completed the study. Children (mean age = 8.0 ± 3.9 years) had mild baseline AD and were diverse by race (39% white; 36% Black) and gender (53% males). Caregivers were mostly female (78%; mean age = 37 ± 7.6 years). Both arms improved disease severity (Eczema Area and Severity Index) from baseline to 12 weeks (CRIS = −2.4 vs. TAC = −1.9). Within‐arm analyses comparing baseline to 12 weeks revealed TAC, but not CRIS, improved all child and caregiver PROs except sleep (all p < 0.05).ConclusionsOur results demonstrated that topical treatment for 12 weeks was more beneficial than 6 weeks, with TAC improving more PROs than CRIS. Future trials should implement PROs to fully understand the impact of AD treatments.
DIF Detection for Multiple Groups: Comparing Three‐Level GLMMs and Multiple‐Group IRT Models
Authors: Köhler Carmen , Khorramdel Lale , Pokropek Artur , Hartig Johannes 
Published: February 2024

AbstractFor assessment scales applied to different groups (e.g., students from different states; patients in different countries), multigroup differential item functioning (MG‐DIF) needs to be evaluated in order to ensure that respondents with the same trait level but from different groups have equal response probabilities on a particular item. The current study compares two approaches for DIF detection: a multiple‐group item response theory (MG‐IRT) model and a generalized linear mixed model (GLMM). In the MG‐IRT model approach, item parameters are constrained to be equal across groups and DIF is evaluated for each item in each group. In the GLMM, groups are treated as random, and item difficulties are modeled as correlated random effects with a joint multivariate normal distribution. Its nested structure allows the estimation of item difficulty variances and covariances at the group level. We use an excerpt from the PISA 2015 reading domain as an exemplary empirical investigation, and conduct a simulation study to compare the performance of the two approaches. Results from the empirical investigation show that the detection of countries with DIF is similar in both approaches. Results from the simulation study confirm this finding and indicate slight advantages of the MG‐IRT model approach.
Product innovation and export strategy
Authors: Chemo Dzukou Kevin Randy , Duvaleix Sabine , Latouche Karine 
Published: February 2024

AbstractThis paper analyses the relationship between innovation and export performance. More specifically, we highlight the effect of the introduction of new products on the quality and prices charged by firms in international markets. We develop a model to explain the mechanism underlying the relationship between innovation and product quality. Using a unique database of new product launches combined with data on production and trade in the French dairy industry, we tested this mechanism in several ways. Our results show that the export prices charged by the firms increase after the introduction of a new product in a given market. We also show that the projected quality of the new product increases after its introduction in a given market. This confirms the quality‐upgrading effect of innovation at the product level.
Lung cancer screening use among screening‐eligible adults with disabilities
Authors: Poghosyan Hermine , Richman Ilana , Sarkar Sayantani , Presley Carolyn J. 
Published: February 2024

AbstractBackgroundLung cancer screening (LCS) use among adults with disabilities has not been well characterized. We estimated the prevalence of LCS use by disability types and counts and investigated the association between disability counts and LCS utilization among LCS‐eligible adults.MethodsWe used cross‐sectional data from the 2019 Behavioral Risk Factor Surveillance System, Lung Cancer Screening Module. Based on the 2013 US Preventive Services Task Force criteria for LCS, the sample included 4407 LCS‐eligible adults, aged 55–79 years, with current or former (quit smoking in the past 15 years) tobacco use history of at least 30 pack‐years. Disability types included limitations in hearing, vision, cognition, mobility, self‐care, and independent living. We also categorized respondents by number of disabilities (no disability, 1 disability, 2 disabilities, 3+ disabilities). We utilized descriptive statistics and multivariable logistic regression analyses to determine the association between disability counts and the receipt of LCS (yes/no) in the past 12 months.ResultsIn 2019, 16.4% of LCS‐eligible adults were screened for lung cancer. Overall, 49.6% of participants had no disability, and 14.5% had >3 disabilities. Mobility was the most prevalent disability type (35.4%), followed by cognitive impairment (18.2%) and hearing (16.6%). LCS was more prevalent in adults with disability in self‐care versus no disability in self‐care (24.0% vs. 15.5%, p = 0.01), disability in independent living versus no disability in independent living (22.2% vs. 15.4%, p = 0.02), and cognitive impairment disability versus no cognitive impairment (22.1% vs. 15.3%, p = 0.03). The prevalence rates of LCS among groups of LCS‐eligible adults with different disability counts were not significant (p = 0.17).ConclusionsDespite the lack of clinical guidelines on LCS among individuals with disabilities, some individuals with disabilities are being screened for lung cancer. Future research should address this knowledge gap to determine clinical benefit versus harm of LCS among those with disabilities.
Efficacy and tolerability of a novel cosmetic growth factor serum when used as part of biweekly diamond tip hydradermabrasion treatments on facial skin
Authors: Huang Priscilla , Mehta Rahul , Emmerich Tanja , Jiang Lily I. , Makino Elizabeth 
Published: February 2024

AbstractBackgroundGrowth factor preparations have demonstrated effectiveness in reversing age‐related changes in facial skin. TNS® Advanced+ Serum (TNS A+ Serum; SkinMedica®, Allergan Aesthetics, an AbbVie Company) and TNS Advanced+ Pro‐Infusion Serum for DiamondGlow® (DG‐TNS A+; Allergan Aesthetics) combine growth factor technology with active botanical ingredients to target signs of skin aging.AimsThis prospective clinical study evaluated the effectiveness and tolerability of biweekly facial hydradermabrasion (DiamondGlow [DG]; Allergan Aesthetics) plus DG‐TNS A+ combined with at‐home topical TNS A+ Serum.MethodsFemales aged 25–65 years with mild to severe facial photodamage received 6 biweekly DG plus DG‐TNS A+ in‐office treatments with at‐home twice‐daily TNS A+ Serum for 12 weeks. Investigator‐assessed clinical grading of multiple skin attributes, subject self‐assessments, instrumentation measurements, and clinical grading of irritation parameters (0–3, none to severe) were conducted at Visit 1, Day 3, and biweekly from Weeks 2–12.ResultsTwenty‐nine women (Fitzpatrick skin types II–VI; 52% White, 41% African American) were enrolled. Immediate significant improvements after 1 DG plus DG‐TNS A+ treatment were observed for fine lines/wrinkles, skin smoothness (visual and tactile), radiance, and hydration (all p ≤ 0.004). From Weeks 6–12, all investigator‐assessed parameters showed significant improvements versus baseline (all p ≤ 0.002 at Week 12). Mean tolerability scores were <1 across parameters. All subjects (100%) were satisfied with results at Weeks 2–12.ConclusionsThe combination of biweekly hydradermabrasion plus DG‐TNS A+ with at‐home TNS A+ Serum treatments was well tolerated and produced immediate, progressive improvement in multiple signs of photoaging in facial skin.
Development of a supportive care framework for breast cancer survivor's unmet needs: A modified Delphi study
Authors: Dai Qian , Liu Xiangyu , Xu Xianghua , Fu Yulu , She Zhengdi , Huang Yuansi , Xia Yimin , Chen Yongyi , Cheng Andy S. K. , Feuerstein Michael 
Published: February 2024

AbstractAimTo establish a supportive care framework for addressing unmet needs among breast cancer survivors, providing practical guidance for healthcare providers to assess and manage these needs, ultimately enhancing the health outcomes and quality of life of breast cancer survivors.DesignWe conducted a two‐round Delphi survey to gather expert opinions regarding the unmet needs supportive care framework for breast cancer survivors.MethodsInitial framework identification and inquiry questionnaire creation was achieved via literature search and expert group discussions, which included 15 experts from nursing practice, clinical medicine, nursing management and nursing education was conducted using a Delphi survey. To establish consensus, a two‐round Delphi poll was done, using criteria based on the mean (≥4.0), coefficient of variation (CV < 0.25) and percentage for entire score (≥20%).ResultsExperts reached a consensus, leading to six care modules, and 28 care entries: Tumour Detection Support (three care entries), Management of Complications of Antitumor Therapy (seven care entries), Healthy Lifestyle Management (five care entries), Sexual and Fertility Support (four care entries), Psychosocial Support (four care entries) and Resource and Linkage Support (five care entries).ConclusionTo address breast cancer survivors' unmet needs, a supportive framework was developed to actively enhance their health outcomes. However, further refinement and feasibility testing using mobile devices or artificial intelligence are required.Implications for the Profession and Patient CareThis pioneering framework prioritises addressing unmet needs and equips healthcare providers to assess and manage these needs effectively, facilitating the implementation of programs aimed at improving the well‐being of breast cancer survivors.Reporting MethodThis study was guided by a modified guideline for the Conducting and Reporting of Delphi Studies (CREDES) (Palliative Medicine, 31(8), 684, 2017).Patient or Public ContributionNo Patient or Public Contribution.Trial and protocol registrationThe Delphi study methodology does not require registration.
Unveiling denture‐induced oral lesions: A comprehensive study on classification and pain assessment
Authors: Findler M. , Perzon O. , Almoznino G. , Zini A. , Sharav Y. , Czerninski R. , Aframian D. J. , Haviv Y. 
Published: February 2024

AbstractBackgroundDenture‐induced oral Lesions (DIOLs) often manifests shortly after the placement or adjustment of new or realigned dentures, frequently resulting in severe pain and discomfort.ObjectivesThis study aimed to classify DIOLs placing a particular emphasis on assessing the associated pain.MethodsA prospective case study was conducted involving 126 patients who were fitted with a total of 193 dentures of various types at the Hadassah School of Dental Medicine. All patients underwent comprehensive intra‐oral examinations within 1–8 weeks following denture delivery, completed symptom questionnaires and had their medical records reviewed. Key variables documented included age, gender, overall health status, denture type, and a detailed description of the DIOLs. The description encompassed factors such as lesion location, shape, colour, size, border characteristics, ulcerative appearance, membrane coverage, 3D morphology (elevated, immersed and flat) and patient‐reported Verbal Pain Score (VPS) when touching the DIOLs, when wearing the denture, and when not wearing the denture.ResultsNotably, 25.4% of denture wearers required no adjustments, while 14.4% necessitated more than three revisions. A majority (71.8%) of DIOLs cases were associated with mandibular complete dentures, primarily situated on the alveolar ridge. The mean VPS indicated a pain intensity of 7 ± 2.1, with temporary dentures in both jaws causing the most discomfort. Implant‐supported overdentures were particularly painful when placed in the mandible. Additionally, VPS scores were higher among older individuals and those with prior prosthetic experiences. A significant correlation was observed between pain intensity and presence of chronic health condition (0.036).ConclusionsThis study revealed distinct characteristics of DIOLs and highlighted the multifactorial nature of pain experienced following the development of DIOLs. Insights into the influence of patient and denture characteristics on DIOLs and pain intensity can guide healthcare professionals in optimising patient comfort and satisfaction.
A demographic survey of the Davis Strait polar bear subpopulation using physical and genetic capture‐recapture‐recovery sampling
Authors: Dunham Kylee D. , Dyck Markus G. , Ware Jasmine V. , Derocher Andrew E. , Regehr Eric V. , Stern Harry L. , Stenson Garry B. , Koons David N. 
Published: February 2024

AbstractConducting assessments to understand the effects of changing environmental conditions on polar bear (Ursus maritimus) demography has become increasingly important to inform management and conservation. Here, we combined physical (2005–2007) and genetic (2017–2018) mark‐recapture with harvest recovery data (2005–2018) to estimate demographic rates of the Davis Strait polar bear subpopulation and examine the possible effects of climate, dynamic ice habitat, and prey resources on survival. Large sample sizes (e.g., 2,513 marked animals) allowed us to estimate temporal variation in annual survival rates using multistate mark‐recapture‐recovery models. We did not detect statistically significant effects of climate, ice habitat, and prey during the 13‐year study. Estimated total abundance in 2006 was 2,190, credible interval (CRI) [1,954, 2,454] and 1,944, CRI [1,593, 2,366] in 2018. Geometric mean population growth rate (0.99, 95% CRI [0.97, 1.01]) indicated the subpopulation may have declined slightly between 2006 and 2018. However, we did not detect a declining trend in survival or substantial change in reproductive metrics over this period. Given forecasts of major environmental change we emphasize the need to review monitoring programs for this subpopulation.
Scepticism, evidential holism and the logic of demonic deception
Authors: Okasha Samir 
Published: February 2024

AbstractSceptical arguments in epistemology typically employ sceptical hypotheses, which are rivals to our everyday beliefs so constructed that they fit exactly the evidence on which those beliefs are based. There are two ways of using a sceptical hypothesis to undermine an everyday belief, giving rise to two distinct sorts of sceptical argument: underdetermination‐based and closure‐based. However, both sorts of argument, as usually formulated in the literature, fall foul of evidential holism, for they ignore the crucial role of background beliefs. An analogy with the philosophy of science makes this point explicit. There is no simple way to “holism proof” the two sceptical arguments.
Arbuscular mycorrhiza convey significant plant carbon to a diverse hyphosphere microbial food web and mineral‐associated organic matter
Authors: Kakouridis Anne , Yuan Mengting , Nuccio Erin E. , Hagen John A. , Fossum Christina A. , Moore Madeline L. , Estera‐Molina Katerina Y. , Nico Peter S. , Weber Peter K. , Pett‐Ridge Jennifer , Firestone Mary K. 
Published: February 2024

Summary

Arbuscular mycorrhizal fungi (AMF) transport substantial plant carbon (C) that serves as a substrate for soil organisms, a precursor of soil organic matter (SOM), and a driver of soil microbial dynamics. Using two‐chamber microcosms where an air gap isolated AMF from roots, we 13CO2‐labeled Avena barbata for 6 wk and measured the C Rhizophagus intraradices transferred to SOM and hyphosphere microorganisms.

NanoSIMS imaging revealed hyphae and roots had similar 13C enrichment. SOM density fractionation, 13C NMR, and IRMS showed AMF transferred 0.77 mg C g−1 of soil (increasing total C by 2% relative to non‐mycorrhizal controls); 33% was found in occluded or mineral‐associated pools.

In the AMF hyphosphere, there was no overall change in community diversity but 36 bacterial ASVs significantly changed in relative abundance. With stable isotope probing (SIP)‐enabled shotgun sequencing, we found taxa from the Solibacterales, Sphingobacteriales, Myxococcales, and Nitrososphaerales (ammonium oxidizing archaea) were highly enriched in AMF‐imported 13C (> 20 atom%). Mapping sequences from 13C‐SIP metagenomes to total ASVs showed at least 92 bacteria and archaea were significantly 13C‐enriched.

Our results illustrate the quantitative and ecological impact of hyphal C transport on the formation of potentially protective SOM pools and microbial roles in the AMF hyphosphere soil food web.
Belowground morphology as a clue for plant response to disturbance and productivity in a temperate flora
Authors: Klimešová Jitka , Herben Tomáš 
Published: February 2024

Summary
Plants possess a large variety of nonacquisitive belowground organs, such as rhizomes, tubers, bulbs, and coarse roots. These organs determine a whole set of functions that are decisive in coping with climate, productivity, disturbance, and biotic interactions, and have been hypothesized to affect plant distribution along environmental gradients.
We assembled data on belowground organ morphology for 1712 species from Central Europe and tested these hypotheses by quantifying relationships between belowground morphologies and species optima along ecological gradients related to productivity and disturbance. Furthermore, we linked these data with species co‐occurrence in 30 115 vegetation plots from the Czech Republic to determine relationships between belowground organ diversity and these gradients.
The strongest gradients determining belowground organ distribution were disturbance severity and frequency, light, and moisture. Nonclonal perennials and annuals occupy much smaller parts of the total environmental space than major types of clonal plants. Forest habitats had the highest diversity of co‐occurring belowground morphologies; in other habitats, the diversity of belowground morphologies was generally lower than the random expectation.
Our work shows that nonacquisitive belowground organs may be partly responsible for plant environmental niches. This adds a new dimension to the plant trait spectrum, currently based on acquisitive traits (leaves and fine roots) only.
Combined GWAS and eGWAS reveals the genetic basis underlying drought tolerance in emmer wheat (Triticum turgidum L.)
Authors: Yang Guang , Pan Yan , Pan Wenqiu , Song Qingting , Zhang Ruoyu , Tong Wei , Cui Licao , Ji Wanquan , Song Weining , Song Baoxing , Deng Pingchuan , Nie Xiaojun 
Published: February 2024

Summary

Drought is one of the major environmental constraints for wheat production world‐wide. As the progenitor and genetic reservoir of common wheat, emmer wheat is considered as an invaluable gene pool for breeding drought‐tolerant wheat.

Combining GWAS and eGWAS analysis of 107 accessions, we identified 86 QTLs, 105 462 eQTLs as well as 68 eQTL hotspots associating with drought tolerance (DT) in emmer wheat.

A complex regulatory network composed of 185 upstream regulator and 2432 downstream drought‐responsive candidates was developed, of which TtOTS1 was found to play a negative effect in determining DT through affecting root development.

This study sheds light on revealing the genetic basis underlying DT, which will provide the indispensable genes and germplasm resources for elite drought tolerance wheat improvement and breeding.