bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of autonomous robotic surgery for dental implant placement in fully edentulous patients: A retrospective case series study
Authors: Li Ping , Chen Jiahao , Li An , Luo Ke , Xu Shulan , Yang Shuo 
Published: October 2023

AbstractObjectivesThis study evaluated the accuracy of dental implant placement using the robotic computer‐assisted implant surgery (r‐CAIS) technology in fully edentulous patients.Materials and MethodsFully edentulous and terminal dentition patients were enrolled for r‐CAIS technology. Based on the cone‐beam computed tomography (CBCT) examination, a customized positioning marker and a preoperative surgical plan were created before surgery. During the implant surgery, the implant osteotomy and placement were automatically performed using an autonomous robotic surgery system under the surgeon's supervision. A postoperative CBCT scan was used to determine the discrepancies between the planned and placed implants.ResultsTen patients with 59 implants underwent autonomous robotic surgery. No adverse surgical events occurred. The deviations of global coronal, global apical, and angular were 0.67 ± 0.37 mm (95% CI: 0.58–0.77 mm), 0.69 ± 0.37 mm (95% CI: 0.59–0.78 mm), and 1.27° ± 0.59° (95% CI: 1.42°–1.11°), respectively.ConclusionsThe autonomous r‐CAIS technology proved an accurate surgical approach for implant placement in fully edentulous patients due to the control of the angular deviation. Autonomous robotic surgery seems promising as an accurate technology for treating fully edentulous patients. However, further trials are required to provide more hard clinical evidence.
Prioritizing conservation efforts based on future habitat availability and accessibility under climate change
Authors: Liang Jie , Wang Wanting , Cai Qing , Li Xin , Zhu Ziqian , Zhai Yeqing , Li Xiaodong , Gao Xiang , Yi Yuru 
Published: October 2023

AbstractThe potential for species to shift their ranges to avoid extinction is contingent on the future availability and accessibility of habitats with analogous climates. To develop conservation strategies, many previous researchers used a single method that considered individual factors; a few combined 2 factors. Primarily, these studies focused on identifying climate refugia or climatically connected and spatially fixed areas, ignoring the range shifting process of animals. We quantified future habitat availability (based on species occurrence, climate data, land cover, and elevation) and accessibility (based on climate velocity) under climate change (4 scenarios) of migratory birds across the Yangtze River basin (YRB). Then, we assessed species’ range‐shift potential and identified conservation priority areas for migratory birds in the 2050s with a network analysis. Our results suggested that medium (i.e., 5–10 km/year) and high (i.e., ≥ 10 km/year) climate velocity would threaten 18.65% and 8.37% of stable habitat, respectively. Even with low (i.e., 0–5 km/year) climate velocity, 50.15% of climate‐velocity‐identified destinations were less available than their source habitats. Based on our integration of habitat availability and accessibility, we identified a few areas of critical importance for conservation, mainly in Sichuan and the middle to lower reaches of the YRB. Overall, we identified the differences between habitat availability and accessibility in capturing biological responses to climate change. More importantly, we accounted for the dynamic process of species’ range shifts, which must be considered to identify conservation priority areas. Our method informs forecasting of climate‐driven distribution shifts and conservation priorities.
Human neural stem cells
Authors: Wang Yu‐Kai , Yu Juan , Zhang Ting‐Ting , Ma Ai‐Jin , Hao Jie , Chen Yue‐Jun , Liu Chang‐Mei , Liu Yan , Wang Chang‐Lin , Zhai Pei‐Jun , Xiang Andy Peng , Li Tian‐Qing , Tang Tie‐Shan , Chen Hong , Bao Xin‐Jie , Wang Yan‐Lin , He Wen‐Yan , Fan Jing , Teng Zhao‐Qian , Wang Liu , Zhou Jia‐Xi , Fu Bo‐Qiang , Fu Yu Vincent , Feng Lin , Cao Jia‐Ni , Liang Ling‐Min , Wang Lei , Zhou Qi , Zhang Yu , Hu Bao‐Yang , Zhao Tong‐Biao 
Published: October 2023

Abstract‘Human neural stem cells’ jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human neural stem cells (hNSCs) in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hNSCs, which is applicable to the quality control for hNSCs. It was originally released by the China Society for Cell Biology on 30 August 2022. We hope that publication of the guideline will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hNSCs for clinical development and therapeutic applications.
Precision medicine in regulatory decision making: Biomarkers used for patient selection in European Public Assessment Reports from 2018 to 2020
Authors: Bakker Elisabeth , Starokozhko Viktoriia , Kraaijvanger Jet W. M. , Heerspink Hiddo J. L. , Mol Peter G. M. 
Published: October 2023

AbstractBiomarkers can guide precision medicine in clinical trials and practice. They can increase clinical trials' efficiency through selection of study populations more likely to benefit from treatment, thus increasing statistical power and reducing sample size requirements or study duration. We performed a narrative synthesis to explore biomarker utilization for patient selection to guide precision medicine trials in marketing authorization dossiers of centrally approved medicines in Europe between 2018 and 2020 and analyzed in‐depth those that eventually included biomarkers in the medicines' indications. From 119 eligible products, 26 included a biomarker in the indication, of which most were oncology products (n = 15). Included biomarkers were often known from literature or from previously approved products in the European Union or the United States. Additionally, 52 dossiers mentioned one or more biomarkers for patient selection in their clinical efficacy and safety information. Although these were not always included in the medicines' indication, they were often implicitly embedded in condition definitions adopted from clinical guidelines or practice. In 15 out of the 26 medicines with a biomarker‐guided indication, only biomarker‐positive populations were included in the main clinical studies supporting the marketing authorization. These studies were mostly randomized controlled trials or single‐arm trials; only two products were studied for multiple indications in an innovative basket trial. Definitions of biomarkers could be subject of debate and needed adaptation after post hoc analyses requested by the assessment committee in four cases, stressing the importance of thorough justification of these definitions to include the right population for an optimal benefit–risk balance, enabling precise medicine.
Family‐based consent and motivation for familial organ donation in Bangladesh: An empirical exploration
Authors: Siraj Md. Sanwar 
Published: October 2023

AbstractThe government of Bangladesh approved the human organ transplantation law in 1999 and updated it in 2018. This legislation approved both living‐related donor and posthumous organ transplantation. The law only allows family members to legally donate organs to their relatives. The main focus of this study was to explore how Bangladeshis make donation decisions on familial organs for transplantation. My ethnographic fieldwork with forty participants (physicians and nurses, a healthcare administrator, organ donors, recipients, and their relatives) disclosed that the organ donation decision was family‐based. An assessment of the relationship between religion, culture, and biomedicine leads to the conclusion that deciding on donating organs to relatives is primarily family‐based and is perceived to be steeped in Islamic ethical principles and religious cultural tradition. The family‐based consent and motivation for donor‐recipient pair organ transplantation strengthen an altruistic environment for the family and act as the moral and legal authority that ensures ethical healthcare outcomes for Bangladeshis.
Technologies for whole‐cell modeling: Genome‐wide reconstruction of a cell in silico
Authors: Kaizu Kazunari , Takahashi Koichi 
Published: October 2023

AbstractWith advances in high‐throughput, large‐scale in vivo measurement and genome modification techniques at the single‐nucleotide level, there is an increasing demand for the development of new technologies for the flexible design and control of cellular systems. Computer‐aided design is a powerful tool to design new cells. Whole‐cell modeling aims to integrate various cellular subsystems, determine their interactions and cooperative mechanisms, and predict comprehensive cellular behaviors by computational simulations on a genome‐wide scale. It has been applied to prokaryotes, yeasts, and higher eukaryotic cells, and utilized in a wide range of applications, including production of valuable substances, drug discovery, and controlled differentiation. Whole‐cell modeling, consisting of several thousand elements with diverse scales and properties, requires innovative model construction, simulation, and analysis techniques. Furthermore, whole‐cell modeling has been extended to multiple scales, including high‐resolution modeling at the single‐nucleotide and single‐amino acid levels and multicellular modeling of tissues and organs. This review presents an overview of the current state of whole‐cell modeling, discusses the novel computational and experimental technologies driving it, and introduces further developments toward multihierarchical modeling on a whole‐genome scale.
Pathophysiological interactions between sarcopenia and type 2 diabetes: A two‐way street influencing diagnosis and therapeutic options
Authors: Tack Wouter , De Cock Anne‐Marie , Dirinck Eveline Lia , Bastijns Sophie , Ariën Femke , Perkisas Stany 
Published: October 2023

AbstractThis review will try to elucidate the interconnected pathophysiology of sarcopenia and type 2 diabetes (T2D) and will try to identify a common pathway to explain their development. To this end, the PubMed and Scopus databases were searched for articles published about the underlying pathophysiology, diagnosis and treatment of both sarcopenia and T2D. The medical subject heading (MeSH) terms ‘sarcopenia’ AND ‘diabetes mellitus’ AND (‘physiopathology’ OR ‘diagnosis’ OR ‘therapeutics’ OR ‘aetiology’ OR ‘causality’) were used. After screening, 32 papers were included. It was evident that sarcopenia and T2D share multiple pathophysiological mechanisms. Common changes in muscle architecture consist of a shift in myocyte composition, increased myosteatosis and a decreased capacity for muscle regeneration. Further, both diseases are linked to an imbalance in myokine and sex hormone production. Chronic low‐grade inflammation and increased levels of oxidative stress are also known pathophysiological contributors. In the future, research efforts should be directed towards discovering common checkpoints in the development of T2D and sarcopenia as possible shared therapeutic targets for both diseases. Current treatment for T2D with biguanides, incretins and insulin may already convey a protective effect on the development of sarcopenia. Furthermore, attention should be given to early diagnosis of sarcopenia within the population of people with T2D, given the sizeable physical and medical burden it encompasses. A combination of simple diagnostic techniques could be used at regular diabetes check‐ups to identify sarcopenia at an early stage and start lifestyle modifications and treatment as soon as possible.
The ongoing lateral expansion of peatlands in Finland
Authors: Juselius‐Rajamäki Teemu , Väliranta Minna , Korhola Atte 
Published: October 2023

AbstractPeatlands are the most dense terrestrial carbon stock and since the last glacial epoch northern peatlands have accumulated between 400 and 1000 Gt of carbon. Although the horizontal development history of the peatlands during the Holocene has been previously researched, these studies have overlooked the current peatland margins. This has led to a long‐standing view that the lateral expansion of the peatlands has halted or significantly slowed down. However, no concentrated effort focusing on the recent development of the peatland margins has been conducted. To fulfil this knowledge gap, we studied the development of peatland margins in five Finnish peatlands. In addition, we studied the effect of peatland subsoil characteristics and past forest fires on the peatland expansion. We sampled 15 transects with a total of 47 peat cores utilizing 14C radiocarbon dating on the basal layers of these peat cores. Our results show that the Northern peatlands are still expanding with four of our study sites having recent, post‐1950's basal ages in the peatland margins. In addition, the rate of peatland lateral expansion has increased during the last 1500 years in our study sites, challenging the current knowledge of the recent peatland expansion dynamics. We recorded lateral expansion rates of 0.1–6.4 cm/year from the sites studied. The rate of lateral expansion was restricted by local characteristics, especially the steepness of subsoil (p = .0108). Forest fires likely played an important role as the trigger for lateral expansion in southern study sites with large number of charcoal found at the basal layer of the peat cores. Depending on the scope of this recent lateral expansion across the vast northern peatlands, the effect on the carbon balance could be significant and should be taken into account when estimating the development of carbon pools in these crucial ecosystems.
Physicochemical properties and biological activities of litchi glycans with different molecular weights
Authors: Tan Feng‐Xiang , Yu Yuan‐Shan , Xu Yu‐Juan , Wu Ji‐Jun , Xiao Geng‐Sheng , Hu Teng‐Gen 
Published: October 2023

SummaryIn this study, three litchi glycans (Lzp1–Lzp3) with molecular weights (Mw) of 2.25 × 106 Da, 6.00 × 103 Da and 3.24 × 102 Da were purified, and their structural characteristics, biological activities and structure–activity relationships were investigated. The results showed that Lzp1–Lzp3 had similar inhibitory effects on Escherichia coli and Staphylococcus aureus, as evidenced by the fact that there were no significant correlations between the Mw, active groups, monosaccharide compositions of Lzp1–Lzp3 and their antimicrobial activities. Lzp1 consisted of more mannose, galactose and arabinose, and less ribose and xylose, thus leading to its higher antioxidant activities of DPPH, ABTS, hydroxyl and superoxide radical scavenging and ferric‐ion reducing with the values of 78.0%, 99.0%, 90.2%, 1.08 and 3.93 respectively. Lzp2 contained more sulphonic acid and uronic acid, and the least glucose possessed the best effect on the promotion of exopolysaccharide production (24.77 mg/mL) by Weissella confusa, and the proliferation of Weissella confusa, Lacticaseibacillus rhamnosus, Bifidobacterium bifidum and Bifidobacterium breve with the OD600 ranging from 0.278–1.082. This study can provide a reference for the preparation of litchi glycans possessed specific biological activity.
RETRACTED: Effects of bundle‐care interventions on pressure ulcers in patients with stroke: A meta‐analysis
Authors: Wang Li‐Ping , Gao Ming‐Ming , Wang Xiu‐Qin , Gu Min‐Min , Qi Qin‐De 
Published: October 2023

AbstractWe conducted a meta‐analysis to assess the effects of bundle‐care interventions on pressure ulcers in patients with stroke to provide a basis for clinical work. Randomised controlled trials on the effects of bundle‐care interventions in patients with stroke were identified using computerised searches of the PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, VIP and Wanfang databases, from the time of inception of each database to July 2023, supplemented by manual literature searches. Two researchers independently retrieved and screened the articles, extracted the data and evaluated the quality of the included studies. After reaching consensus, meta‐analysis was performed using RevMan 5.4. Twenty‐four papers were included, involving 3330 patients of whom 1679 were in the intervention group and 1651 were in the control group. The results showed that, compared with standard care, bundle‐care interventions significantly reduced the incidence of pressure ulcers (3.28% vs. 14.84%, odds ratio [OR]: 0.19, 95% confidence interval [CI]: 0.14–0.26, p < 0.001), and aspiration (5.60% vs. 18.84%, OR: 0.25, 95% CI: 0.17–0.39, p < 0.001), and improved patient satisfaction with nursing care (96.59% vs. 84.43%, OR. 5.45, 95% CI: 3.76–7.90, p < 0.001). Current evidence suggests that care bundles are significantly better than conventional nursing measures in preventing pressure ulcers and aspiration, and improving patient satisfaction with nursing care in patients with stroke, and are worthy of clinical promotion and application.
Effect of robotic versus laparoscopic surgery on postoperative wound infection in patients with cervical cancer: A meta‐analysis
Authors: Huang Jin , Tan Zhe , Wu Wenyue , Wu Xiuqian , Liu Lian , Li Chunlin 
Published: October 2023

AbstractThe objective of this research is to evaluate the risk of postoperative infection and other risks associated with robotic radical hysterectomy (RRH) compared with laparoscopic radical hysterectomy (LRH). Recent studies on RRH versus LRH have not been conclusive for cervical carcinoma. Our group attempted to use meta‐analyses to evaluate the effects of both RRH and LRH on postoperative outcomes in order to make sure that the best operative method was used to prevent wound infections. We looked up Cochrane Library and published databases for this research and found 594 findings. Articles were screened by title and abstract and then carefully examined for inclusion and exclusion criteria. Data extraction was performed independently by two researchers. Comparison studies were used to describe the incidence of wound complications after surgery. The publication bias was assessed using Egger regression correlation analysis. There were six trials eligible for inclusion, of which 491 RRH and 807 LRH. Depending on surgery for cervical carcinoma, it is true that there is a difference in the way that surgery affects the postoperative complications. Our analysis demonstrated that the use of robotic operation can decrease the amount of blood loss during operation as compared with routine laparoscopy (MD, −77.69; 95% CI, −132.08, −23.30; p = 0.005). However, there were no statistical differences in the incidence of postoperative wound infections (OR, 0.54; 95% CI, 0.25, 1.19; p = 0.13) and intraoperative operative time (MD, 13.01; 95% CI, −41.38, 67.41; p = 0.64) among the two procedures. There was no statistically significant difference between these two groups of patients with severe postoperative complications. Unlike other research, the findings of this meta‐analysis are not consistent with the findings of the present study, which suggest that robotic operations cannot lower the rate of postoperative wound infections. However, because of the limitations and the retrospective character of the trials covered, these findings should be interpreted with care and more extensive research is required.
Crystal structure and phase formation of MgO–MoO3‐based ceramics with ultralow dielectric loss: A comprehensive study
Authors: Li Xiaoyu , Wang Hongye , Xu Xinwei , Chen Naichao , Guo Biao , Cheng Jin , Chen Xianqiang , Wang Hong 
Published: October 2023

AbstractThe MgO‐MoO3 system shows significant potential for applications in microwave dielectric ceramics. However, the formation mechanism, crystal structures, and microwave dielectric properties of this system have not been systematically investigated. This work aims to comprehensively study the crystal structures, phase transitions, and microwave dielectric properties of compounds in the MgO‐MoO3 system. In particular, the research delves into the unexplored transformation mechanism from β‐MgMo2O7 to α‐MgMo2O7 and MgMoO4. As a result, the three compounds exhibiting favorable microwave dielectric properties have been successfully fabricated. These compounds can be effectively sintered at temperatures ranging from 685 to 900°C and exhibited dielectric constants (εr) ranging from 5.41 to 6.89, as well as Qf values ranging from 100 000 to 130 000 GHz. Additionally, prototype microstrip antennas are designed and fabricated using β‐MgMo2O7 and MgMoO4 ceramics as substrates. The obtained antenna's performance is excellent, with S11 values below −30 dB and a gain exceeding 6 dB at 5.8 GHz, highlighting the potential of the developed ceramics for practical applications in microwave devices.
Integrin beta1 mediates the effect of telocytes on mesenchymal stem cell proliferation and migration in the treatment of acute lung injury
Authors: Qi Ruixue , Hou Jiayun , Yang Ying , Yang Zhicheng , Wu Lihong , Qiao Tiankui , Wang Xiangdong , Song Dongli 
Published: October 2023

AbstractCo‐transplantation of mesenchymal stem cells (MSCs) with telocytes (TCs) was found to have therapeutic effects, although the mechanism of intercellular communication is still unknown. Our current studies aim at exploring the potential molecular mechanisms of TCs interaction and communication with MSCs with a focus on integrin beta1 (ITGB1) in TCs. We found that the co‐culture of MSCs with ITGB1‐deleted TCs (TCITGB1‐ko) changed the proliferation, differentiation and growth dynamics ability of MSC in responses to LPS or PI3K inhibitor. Changes of MSC proliferation and apoptosis were accompanied with the dysregulation of cytokine mRNA expression in MSCs co‐cultured with TCITGB1‐ko during the exposure of PI3Kα/δ/β inhibitor, of which IL‐1β, IL‐6 and TNF‐α increased, while IFN‐γ, IL‐4 and IL‐10 decreased. The responses of PI3K p85, PI3K p110 and pAKT of MSCs co‐cultured with TCITGB1‐ko to LPS or PI3K inhibitor were opposite to those with ITGB1‐presented TCs. The intraperitoneal injection of TCITGB1‐ko, TCvector or MSCs alone, as well as the combination of MSCs with TCITGB1‐ko or TCvector exhibited therapeutic effects on LPS‐induced acute lung injury. Thus, our data indicate that telocyte ITGB1 contributes to the interaction and intercellular communication between MSCs and TCs, responsible for influencing other cell phenomes and functions.