bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile Mechanochemical Reduction and Lithium‐Ion Doping of Transition‐Metal Oxides[]**
Authors: Davison Nathan , Khatun Tanima , Arce‐Garcia Isabel , Gould Jamie A. , Dawson James A. , Lu Erli 
Published: October 2023

AbstractTransition‐metal oxides (MOx) play essential roles in chemistry, catalysis, materials science and metallurgy. The MOx reduction and doping are two ubiquitous reactions in academic research and industrial manufacturing, but they are notoriously energy‐demanding and require harsh conditions (high temperatures, long durations). In this work, facilitated by mechanochemical ball milling, we report a new route to conduct MOx reduction and doping at room temperature within 20 minutes enabled by mechanochemical ball milling and lithium metal.
On the Coordination Chemistry of Triazolyl‐substituted Diborane Ligands, Prepared by 1,3‐dipolar Cycloaddition Reactions between Diazido‐diboranes and Alkynes
Authors: Vogler Daniel , Schenker Maurice , Ng Kim Hao , Kaifer Elisabeth , Himmel Hans‐Jörg 
Published: October 2023

AbstractMetal‐free cycloaddition reactions between a diazido‐diborane and alkynes are used to synthesize new ditriazolyl‐diborane molecules, a bis(ferrocenyl‐1,2,3‐triazolyl)‐diborane and a bis(2‐pyridyl‐1,2,3‐triazolyl)‐diborane. Then, the bis(2‐pyridyl‐1,2,3‐triazolyl)‐diborane was used as polydentate ligand for the synthesis of larger architectures. Reaction with ditriflato‐diborane yielded a tetracationic hexaboron compound, and reaction with metal salts yielded dicationic ring compounds with two hexacoordinate metal atoms and two integrated diborane units.
Construction and contestation of climate activist identities in the comments section of a large UK‐based online newspaper
Authors: Lewis Harry M. , Vignoles Vivian L. 
Published: October 2023

AbstractSuccess of global attempts to limit climate change depends partly upon public support for demands of climate activist groups. We examined the role of social representation and identity processes in shaping opposition to climate activism, through a discursive thematic analysis of 628 online comments on 20 MailOnline articles about climate activists. Members of the commenting community propagated representations of climate activists as an immoral and incompetent, low‐value to society, ideological Other. Commenters contrasted negative representations of activists with constructions of their own shared identity as hardworking, moral and competent. These constructions serve to undermine and delegitimize the activist voice, while simultaneously advancing a political project rooted in ideological and class‐based concerns. Future research might explore the possibility of engaging wider support through generating competing representations of activist identity. Our research illustrates the value of jointly focusing on social representations and social identity processes for understanding issue‐based societal polarisation.
A systematic review of tea pigments: Prevention of major diseases, protection of organs, and potential mechanisms and applications
Authors: Zhao Xuan , Yan Fei , Li Xin‐Sheng , Qu Dong , Xu Yue‐Ling 
Published: October 2023

AbstractWith the growing awareness of a healthy life, tea pigments (TPGs) are in focus for their health benefits. TPGs not only provide specific color to tea liquor but also possess health benefits such as anti‐obesity, anti‐tumor, anti‐inflammatory, anti‐viral, anti‐oxidative, and bacteriostatic properties. Also, TPGs can benefit bone, liver, kidney, cardiovascular, gut microbiome, and sleep health. Based on previous reports, this review provides a brief introduction to the health benefits of TPGs, focusing on the prevention of human diseases and the protection of organs. Also, the latest research on the functional mechanism(s), practical application, and development strategies of TPGs is discussed.
Chondroprotective effects of Protaetia brevitarsis seulensis larvae as an edible insect on osteoarthritis in mice
Authors: Chun Jin Mi , Nam Hyeon‐Hwa , Lee Ji Hye , Seo Young Hye , Kim Hyo Seon , Moon Byeong Cheol , Park Jun Hong 
Published: October 2023

AbstractOsteoarthritis (OA) is a common chronic joint inflammatory disease characterized by progressive destruction of the articular cartilage, bone remodeling, and excessive chronic pain. Most therapeutic approaches do not rescue the progression of OA effectively or provide relief of symptoms. Protaetia brevitarsis seulensis larva (PBSL), which is attracting attention, is an edible insect with very high nutritional value and herbal medicine for the treatment of blood stasis, hepatic disease, and various inflammatory diseases. However, the effect of PBSL on OA has not yet been investigated. This study aimed to demonstrate the effects of PBSL water extract on the progression of OA using monosodium iodoacetate (MIA)‐induced mice and SW1353 chondrocytes or murine macrophages. We injected MIA into the intraarticular area of mice following pretreatment with either saline or PBSL (200 mg/kg) for 2 weeks, and then locomotor activity, microcomputed tomography and histopathological analysis, quantitative reverse transcriptase–polymerase chain reaction analysis, and western blot analysis were performed. To determine the molecular effects of PBSL, we used interleukin‐1β (IL‐1β)‐induced SW1353 chondrosarcoma or lipopolysaccharide (LPS)‐stimulated macrophages. Pretreatment with PBSL diminished the symptoms of OA. Physical activity, articular cartilage damage, and the generation of microfractures were rescued by pretreatment with PBSL in the mouse model. Pretreatment with PBSL suppressed the progress of OA through the regulation of articular cartilage degradation genes and inflammation in both in vivo and in vitro models. Our results demonstrated that PBSL has value as edible insect that can be used in the development of functional foods for OA.
Preoperative urine neutrophil gelatinase‐associated lipocalin predicts mortality in colorectal cancer patients after laparoscopic surgery: A single‐center study
Authors: Huynh Thanh Long , Dao Bui Quy Quyen , Nguyen Manh Khiem , Nguyen Huu Dung , Nguyen Trung Kien , Le Viet Thang 
Published: October 2023

AbstractPurposeTo determine the rate of acute kidney injury (AKI) after laparoscopic colorectal cancer (CRC) surgery and the predictive value of urine neutrophil gelatinase‐associated lipocalin (uNGAL) for postoperative AKI and mortality during 3 years of follow‐up.MethodsA total of 216 CRC patients who had undergone laparoscopic surgery were included in our study. We divided all patients into two groups, including group 1 (n = 31) with postoperative AKI and group 2 (n = 185) without postoperative AKI. Urine NGAL was measured using the ELISA technique. Clinical and laboratory data were collected the day before surgery. Postoperative AKI included events occurring within 7 days of the index operation, and mortality was obtained during 3 years of follow‐up.ResultsThe ratio of postoperative AKI was 14.35% (31/216 patients). The urine NGAL level in group 1 was significantly higher than in group 2, p < 0.001. At cut‐off value = 14.94 ng/mL, uNGAL has a predictive value for AKI (area under the curve [AUC] = 0.858, p < 0.001). After 3 years of follow‐up, the total mortality rate was 7.9%. The mortality rate in group 1 (45.2%) was significantly higher than in group 2 (1.6%) with p < 0.001). At cut‐off value = 19.85 ng/mL, uNGAL has a predictive value for mortality (AUC = 0.941, p < 0.001).ConclusionsThe rate of acute kidney injury after laparoscopic CRC surgery was 14.35%. Preoperative urine NGAL has a good predictive value for postoperative acute kidney injury and mortality during 3 years of follow‐up.
Front Cover
Authors: Wang Rui , Zhang Zhipeng , Chen Ruiyi , Yu Xiaohai , Zhang Hongyu , Hu Gang , Liu Qiegen , Song Xianlin 
Published: October 2023

A method based on deep learning was proposed to enhance the defocused resolution and signal‐to‐noise ratio of optical‐resolution photoacoustic microscopy. A fully dense U‐Net was trained with randomly distributed sources of different shapes to improve the quality of photoacoustic images. The results show that the PSNR of defocused signal was enhanced by more than 1.2 times. An over 2.6‐fold enhancement in lateral resolution and an over 3.4‐fold enhancement in axial resolution of defocused regions were achieved.For further details please visit the article by Rui Wang, Zhipeng Zhang, Ruiyi Chen, Xiaohai Yu, Hongyu Zhang, Gang Hu, Qiegen Liu, Xianlin Song (e202300149).
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Temporary unilateral abdominal muscle paralysis due to herpes zoster without typical vesicles or pain
Authors: Eguchi Hitoshi , Furukawa Naoko , Tago Masaki , Fujiwara Motoshi , Ogushi Akihiko , Tokutomi Jun , Choi Seungeon , Yamamoto Kenichi , Yoshihara Kojiro , Yamashita Shu‐ichi 
Published: October 2023

AbstractA 45‐year‐old man was evaluated for right abdominal bulging. Computed tomography showed segmental flaccidity of the right abdominal muscle without an abdominal hernia. Although typical vesicles and pain were absent, we diagnosed herpes zoster (HZ) because of the presence of a few eschars on the affected area without a history of diabetes mellitus. Although transient unilateral abdominal muscle paralysis due to HZ without typical skin vesicles or pain is rare, it is imperative to consider the possibility of HZ and seek skin changes such as eschars in such cases.
Rehabilitative management for aspiration pneumonia in elderly patients
Authors: Momosaki Ryo 
Published: October 2023

AbstractAspiration pneumonia is a common disease that frequently occurs in elderly patients. Most patients with aspiration pneumonia have swallowing disability and develop hospital‐acquired disability. Frequently, patients have difficulty returning home, and they often require long‐term hospitalization. Recently, the effectiveness of rehabilitative management including physical, pulmonary, and dysphagia rehabilitation for aspiration pneumonia was reported. Several studies showed that early rehabilitation was associated with reduced mortality and early hospital discharge after aspiration pneumonia. Unnecessary “nil by mouth” directives associated with aspiration pneumonia at hospital admission resulted in adverse effects, including decline in swallowing ability and prolonged treatment duration. Rehabilitative management combined with appropriate nutrition is recommended to improve clinical outcomes, including physical and swallowing function in geriatric patients with aspiration pneumonia.
A unique case of primary effusion lymphoma‐like lymphoma showing disappearance and recurrence of the body cavity effusion
Authors: Koeda Chikahiko , Sato Takashi , Matsumoto Yuki , Usui Yuta , Kunugida Fusanori , Ogawa Muneyoshi 
Published: October 2023

AbstractPrimary effusion lymphoma‐like lymphoma (PEL‐LL) is a rare B‐cell lymphoma that the etiology remains unclear. We describe a case of PEL‐LL with a pleuropericardial effusion. Diagnosis required long period of time as it followed a unique progress of disappearance and recurrence of the body cavity effusion. We finally had a diagnosis of B‐cell lymphoma by the immunocytochemistry of effusion using the cell block procedure. Authors consider that it is valuable to actively try the cell block procedure at the time of the first drainage for early diagnosis, if the body cavity effusion due to the malignancy is suspected.
A multicenter validation study for determining the condition of nonanatomical or minor anatomical hepatectomies satisfying technical difficulty of current high‐level hepatectomy certificated by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Authors: Matsuki Ryota , Sakamoto Yoshihiro , Yoshida Masao , Ogiso Satoshi , Soyama Akihiko , Seki Yusuke , Tokumitsu Yukio , Eguchi Susumu , Hasegawa Kiyoshi , Nagano Hiroaki , Kokudo Norihiro , Hatano Etsuro 
Published: October 2023

AbstractBackgroundThe current high‐level hepatectomy (HLH) is certified by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS), comprising only anatomical hepatectomies above Couinaud's segmentectomy. This multicenter study aimed to identify the conditions of non‐HLH that satisfy equivalent technical difficulties to HLH.MethodsBetween 2018 and 2021, 595 first open hepatectomies without biliary reconstruction (374 HLHs and 221 non‐HLHs) were performed in the five institutions. Non‐HLHs belonging to at least one of the three conditions; depth of hepatectomy ≥5 cm, number of resections ≥3 locations and at least one location with a depth of hepatectomy ≥3 cm, and hepatectomy involving the paracaval portion of the caudate lobe was proposed as the candidate for difficult non‐HLH. The technical difficulty was estimated by the operative time and blood loss.ResultsDifficult non‐HLHs were neither associated with shorter operative time (373 min vs. 354 min, p = .184) nor lesser blood loss than those with HLHs (503 mL vs. 436 mL, p = .126). Postoperative complications such as Clavien‐Dindo classification grade III or more were not significant between the two groups (18.6% vs. 13.4%, p = 0212).ConclusionsDifficult non‐HLHs were associated with no lesser technical difficulty than those with HLH.
Biennial analysis of probable permafrost distribution for Kullu district, North‐west Himalaya using Landsat 8 satellite data
Authors: Pradhan Ipshita Priyadarsini , Shukla D. P. 
Published: October 2023

AbstractClimate change and increased anthropogenic activity affect permafrost distribution, threatening ecosystem stability, water resources, and greenhouse gas emissions. In this study, we present updated probable permafrost maps at 30 m resolution for Kullu district of Himachal Pradesh derived from the predicted mean annual air temperature (MAAT) (2013 to 2020) based on Landsat 8 land surface temperature (LST). We also analysed the mean annual snow cover extent of the study area for this time period. Our probable permafrost distribution map shows the areas falling under permafrost regions in snow‐covered areas; permafrost regions in non‐snow‐covered areas; non permafrost regions along with glacierised regions. The temporal variation of permafrost over 7 years from 2013 to 2020 shows that permafrost distribution follows a cyclic variation ranging between 4.42% and 7.51% of the total area of the district. The permafrost maps were validated with the presence of rock glaciers as seen on high resolution satellite images and the ground photographs. The maps display the expected spatial pattern of near‐surface air temperatures that match with the known permafrost boundary. The findings of this study provide more precise information on permafrost distribution and essential data for future permafrost research in Kullu district.
Transforming health and well‐being through publishing computable biomedical knowledge (CBK)
Authors: Koru Güneş 
Published: October 2023

AbstractComputable biomedical knowledge artifacts (CBKs) are software programs that transform input data into practical output. CBKs are expected to play a critical role in the future of learning health systems. While there has been rapid growth in the development of CBKs, broad adoption is hampered by limited verification, documentation, and dissemination channels. To address these issues, the Learning Health Systems journal created a track dedicated to publishing CBKs through a peer‐review process. Peer review of CBKs should improve reproducibility, reuse, trust, and recognition in biomedical fields, contributing to learning health systems. This special issue introduces the CBK track with four manuscripts reporting a functioning CBK, and another four manuscripts tackling methodological, policy, deployment, and platform issues related to fostering a healthy ecosystem for CBKs. It is our hope that the potential of CBKs exemplified and highlighted by these quality publications will encourage scientists within learning health systems and related biomedical fields to engage with this new form of scientific discourse.
Coating of Polypropylene Non‐Woven Fabric with Layered Double Hydroxides Bearing Antioxidant and Antibacterial Natural Compounds
Authors: Cicogna Francesca , Passaglia Elisa , Elainaoui Elyazid , Bramanti Emilia , Oberhauser Werner , Casini Beatrice , Tuvo Benedetta , Coltelli Maria‐Beatrice , Panariello Luca , Coiai Serena 
Published: October 2023

AbstractLayered double hydroxides (LDHs) containing immobilized rosmarinic acid or eugenol have been employed to functionalize polypropylene (PP) non‐woven fabric (NWF), commonly used to manufacture protective clothing such as surgical masks. Rosmarinic acid and eugenol have recognized biological activities, such as antimicrobial, antioxidant, and anti‐inflammatory capabilities, and they have been employed in this work both as synthetic, commercial compounds and as raw mixtures extracted from agri‐food matrices. These encapsulated hybrid systems have been designed to gradually release the active molecules while protecting them from degradation processes caused by light and heat. Two different NWF modification strategies have been employed to increase the adhesion capacity of the hybrids: cold plasma treatment with oxygen and polydopamine coating. Both methodologies have increased the amount of hybrid deposited on the NWF surfaces, giving significant resistance to thermo‐oxidation, the controlled migratory capacity of active molecules, and, in the case of the eugenol‐containing system, significant bactericidal activity against Staphylococcus aureus.
Single‐cell RNA sequencing reveals the effects of capsaicin in the treatment of sepsis‐induced liver injury
Authors: Zhang Qian , Liu Jing , Shen Jing , Ou Jinhuan , Wong Yin Kwan , Xie Lulin , Huang Jingnan , Zhang Chunting , Fu Chunjin , Chen Junhui , Chen Jiayun , He Xueling , Shi Fei , Luo Piao , Gong Ping , Liu Xueyan , Wang Jigang 
Published: October 2023

AbstractSepsis is a difficult‐to‐treat systemic condition in which liver dysfunction acts as both regulator and target. However, the dynamic response of diverse intrahepatic cells to sepsis remains poorly characterized. Capsaicin (CAP), a multifunctional chemical derived from chilli peppers, has recently been shown to potentially possess anti‐inflammatory effects, which is also one of the main approaches for drug discovery against sepsis. We performed single‐cell RNA transcriptome sequencing on 86,830 intrahepatic cells isolated from normal mice, cecal ligation and puncture‐induced sepsis model mice and CAP‐treated mice. The transcriptional atlas of these cells revealed dynamic changes in hepatocytes, macrophages, neutrophils, and endothelial cells in response to sepsis. Among the extensive crosstalk across these major subtypes, KC_Cxcl10 shared strong potential interaction with other cells when responding to sepsis. CAP mitigated the severity of inflammation by partly reversing these pathophysiologic processes. Specific cell subpopulations in the liver act collectively to escalate inflammation, ultimately causing liver dysfunction. CAP displays its health‐promoting function by ameliorating liver dysfunction induced by sepsis. Our study provides valuable insights into the pathophysiology of sepsis and suggestions for future therapeutic gain.
Polyvinyl chloride surface coated with polymer brushes using a chain‐transfer reaction for enhanced fouling resistance
Authors: Almousa Rashed , Chen Yong , Li Jiliang , Anderson Gregory G. , Xie Dong 
Published: October 2023

AbstractThis study reports coating negatively charged polymer brushes covalently onto the surface of polyvinylchloride (PVC) using a simple conventional surface free‐radical polymerization technique with help of a chain transfer agent. The coated surfaces were assessed with contact angle, protein adsorption, cell adhesion and bacterial adhesion. Bovine serum albumin (BSA) and bovine fibrinogen (BFG) were used for protein adsorption evaluation. Mouse fibroblast (NIH‐3 T3) cells and Pseudomonas aeruginosa (P. aeruginosa) were used to assess cell and bacterial adhesion. Results show that the surface modified with all the attached polymer brushes exhibited significantly reduced contact angle, protein adsorption, and cell as well as bacterial adhesion, among which the negatively charged polymers showed the extremely low values in all the tests. The negatively charged polymer shows its contact angle at 4.6° as compared to 70° for original PVC. Its BSA, BFG, 3 T3 adhesion and P. aeruginosa adhesion were 93%, 84%, 92%, and 95% lower than original PVC. Furthermore, the PVC surface coated with negatively charged polymer brushes exhibited a hydrogel‐like property. The results indicate placing acrylic acids using a simple surface‐initiated free‐radical polymerization with help of a chain transfer agent onto PVC surface and then converting the acids to negative charges can be an affective and efficient route for fouling resistant applications.
Metameric Brooker's versus Reichardt's zwitterions: Conformational metamorphosis on optoelectronic properties, using coupled‐perturbed and finite field theories
Authors: Pant Divya , Sitha Sanyasi 
Published: October 2023

AbstractThis contribution reports influences of unusual conformational metamorphosis shown by Reichardt's and Brooker's metameric zwitterions by an earlier work, on various intrinsic electronic and optoelectronic properties. Detailed quantum mechanical investigations were carried out using HF, B3LYP, CAM‐B3LYP, and ωB97xD methodologies. Observations suggest that whereas certain properties were directly and strongly influenced by the conformation preferences (twisted vs. planar), others were not strongly inclined to such conformational transformations. Interestingly, even with inherent conformational differences, observed properties were found to have only one major contributing component in each molecule and can be beneficial in one dimensional (1D) or pseudo‐1D chromophore design strategies. Both coupled perturbed (CP) and finite field (FF) theories were used to compute dipole moments, polarizabilities, and hyperpolarizabilities, and so on, and excellent agreements (or exact matching results) were observed between the two theories. Reichardt's metamer was found to be more efficient in many aspects than Brooker's metamer. The direct and strong influences of metameric manipulations on structure–property correlations shown in this work can be adopted as a useful strategy for efficient chromophore design. Such a strategy is useful in the field of nonlinear optics, and may also find applications in various other areas of material sciences.
One‐step site‐specific S‐alkylation of full‐length caveolin‐1: Lipidation modulates the topology of its C‐terminal domain
Authors: Julien Jeffrey A. , Rousseau Alain , Perone Thomas V. , LaGatta David M. , Hong Chan , Root Kyle T. , Park Soohyung , Fuanta René , Im Wonpil , Glover Kerney Jebrell 
Published: October 2023

AbstractCaveolin‐1 is an integral membrane protein that is known to acquire a number of posttranslational modifications upon trafficking to the plasma membrane. In particular, caveolin‐1 is palmitoylated at three cysteine residues (C133, C143, and C156) located within the C‐terminal domain of the protein which could have structural and topological implications. Herein, a reliable preparation of full‐length S‐alkylated caveolin‐1, which closely mimics the palmitoylation observed in vivo, is described. HPLC and ESI‐LC‐MS analyses verified the addition of the C16 alkyl groups to caveolin‐1 constructs containing one (C133), two (C133 and C143), and three (C133, C143, and C156) cysteine residues. Circular dichroism spectroscopy analysis of the constructs revealed that S‐alkylation does not significantly affect the global helicity of the protein; however, molecular dynamics simulations revealed that there were local regions where the helicity was altered positively or negatively by S‐alkylation. In addition, the simulations showed that lipidation tames the topological promiscuity of the C‐terminal domain, resulting in a disposition within the bilayer characterized by increased depth.