bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of digital twin adoption in hospital operation management
Authors: Huang Guanying , Ng S. Thomas , Li Dezhi 
Published: October 2023

AbstractThe hospital is one of the commercial buildings with the most complex and challenging operational management stage, and digital twin has been an important tool to improve the efficiency and quality of hospital operation management (HOM). As the largest developing country in the world, China has realized the potential of digital twin adoption in HOM, but the existing studies lack the systematic analysis of the determinants and the clarifying of their interrelationship. To fill these knowledge gaps, this paper employed Technology-Organization-Environment framework to sort out 12 determinants, and used DEMATEL-ISM method to analyze the interrelationships of determinants. The results showed that government policy was the determinant with the highest centrality degree and had the highest positive causality degree, while reliability was had lowest negative causality degree. User requirement was the only determinant at the root level, while the other three determinants under the environment dimension were at the deep and middle levels. The determinants under organizational dimension were located in the middle level and shallow level, and the determinants under technical dimension were all located in shallow level. Finally, three implications were put forward, including investigating user requirements for digital twin, leveraging support in the external environment and improving adoption readiness within the hospital. This study would not only enrich the academic framework in the field of HOM, but also provide the guidance for adopting digital twin in HOM in China and other similar economies around the world.
Borrowing Stigma and Lender of Last Resort Policies
Authors: Hu Yunzhi , Zhang Hanzhe 
Published: October 2023

AbstractHow should the lender of last resort provide liquidity to banks during periods of financial distress? During the 2008–2010 crisis, banks avoided borrowing from the Fed’s long-standing discount window but actively participated in its special monetary program, the Term Auction Facility, although both programs had the same borrowing requirements. Using an adverse selection model with endogenous borrowing decisions, we explain why the two programs suffer from different stigma costs and how the introduction of TAF incentivized banks’ borrowing. We discuss the empirical relevance of the model’s predictions.[Banks] deliberately did not ask for the liquidity they needed for fear of damaging their reputation—the ‘stigma’ problem… I do not think we were conscious of this before the crisis started and I do not think central banks have a convincing answer to it… This is, I think, still a challenge in how to manage the process of central bank provision of liquidity support. This is one of the big intellectual issues that has not been fully resolved. (Governor Mervyn King, Bank of England (2016))For various reasons, including the competitive format of the auctions, [Term Auction Facility] has not suffered the stigma of conventional discount window lending and has proved effective for injecting liquidity into the financial system… Another possible reason that [Term Auction Facility] has not suffered from stigma is that auctions are not settled for several days, which signals to the market that auction participants do not face an immediate shortage of funds. (Ben Bernanke, testimony to U.S. House of Representatives (2010))
The Tourist Gaze and Rossini's Operas about Others
Authors: Armstrong Stephen 
Published: October 2023

Abstract
This article reconsiders two of Rossini's exoticist farces, L'italiana in Algeri (1813) and Il turco in Italia (1814), in the light of recent theoretical studies in tourism. These operas appeared at the juncture between the eighteenth-century Grand Tour and nineteenth-century mass tourism, and they became implicated in multiple layers of tourist experience. Travellers from faraway countries went to see productions in Italy, yet the operas tell stories of journeys between Italy and the Ottoman Empire. These operas were an object of the tourist gaze even as they perpetuated that gaze through imaginary encounters with exotic others. In the article, I explain the role of Italian opera in tourism at the turn of the eighteenth century and suggest ways in which tourist theory might help us understand Stendhal's operatic encounters, which in turn form part of the documentary basis of my study. I conclude that Rossini and his librettists upended many of the established hierarchies of tourism in these works, offering a fascinating critique of the tourist gaze in the process.
Patients’ self-reported overall wellbeing correlates with concurrent reported symptoms: analysis of the Edmonton Symptom Assessment System
Authors: McKenna Catherine B. , Osei Ernest , Fleury Brooklynn , Swanson Stephanie , Oghinan Christabel , Darko Johnson 
Published: October 2023

Abstract

Background:
The primary intent of cancer treatment is either curative, prolongation of patient life, or to improve patient quality of life; however, treatments are associated with various side effects that may impact patient wellbeing. Thus, understanding the patients’ wellbeing from the patient’s perspective is essential as it could help enable the provision of the necessary support for patients throughout their cancer journey.

Materials and Method:
We analysed Edmonton Symptom Assessment System (ESAS) questionnaire responses completed by 19,288 patients over 201,839 visits to our Cancer Centre. As part of their routine and standard of care, patients completing the questionnaire are asked to score 6 physical and 2 psychological symptoms as well as overall wellbeing using an 11-point numerical rating scale ranging from 0 to 10, where 0 means complete absence of the symptom or best overall wellbeing and 10 means worst possible symptom or worst overall wellbeing. We used the ESAS responses to characterise the relationship between the overall wellbeing score and concurrent symptoms scored by cancer patients.

Results:
Patients reported tiredness and nausea as the physical symptom causing the most and least distress respectively. Patients that reported severe (7–10) wellbeing also scored high mean scores for tiredness (6·2 ± 2·7), drowsiness (4·7 ± 3·1) and lack of appetite (4·4 ± 3·4). Univariate and multivariable logistic regression analysis suggests higher odds for patients to report moderate-to-severe (4–10) wellbeing when they report moderate-to-severe concurrent symptoms compared to none-to-mild concurrent symptoms.

Conclusions:
Our findings suggest that patients’ overall wellbeing as reported by the ESAS system is influenced by a number of concurrent symptoms. Tiredness was found to impact patients’ overall wellbeing to a greater extent than other concurrent symptoms. The sum of physical or psychological symptom scores was stronger indicators of a patient’s overall wellbeing compared to the scores of individual symptoms.
The state of American health coverage: the 2022 elections and the Affordable Care Act
Authors: Gusmano Mickael K. , Thompson Frank J. 
Published: October 2023

AbstractThe Affordable Care Act of 2010 (ACA) was the most significant policy breakthrough to expand health insurance coverage in the USA in 45 years. Culminating a decade-long effort by Republicans to repeal and undermine the ACA, the Trump administration launched a panoply of executive initiatives to sabotage the law. Benefitting from Democratic control of both the House and Senate during its first 2 years, the Biden administration through legislative and executive initiatives made substantial headway in reversing Trump's sabotage and further reinvigorating the ACA. The 2022 elections witnessed a shift in the partisan milieu. Republicans gained control of the House of Representatives; Democrats scored modest gains in state elections. Emphasising two pivotal features of American governance – federalism and the outsized role of the courts – this essay examines the implications of this new partisan context for Biden's efforts to bolster ACA durability prior to the 2024 presidential election.
Continuing Severe Water Shortage in the Water‐Receiving Area of the South‐To‐North Water Diversion Eastern Route Project From 2002 to 2020
Authors: Xu Yuyue , Gun Zhao , Zhao Jianwei , Chen Jianli , Liu Qing , Cheng Xing , Sutanudjaja Edwin H. , Wang Jida , Liu Hehua , Zhan Wenfeng 
Published: October 2023

AbstractThe water‐receiving area of the South‐to‐North Water Diversion Eastern Route Project (SNWDP‐ER) is one of the most severely affected water‐shortage areas in China, and no previous study has been conducted on the changes in water storage in this area. In this study, we combined the latest Gravity Recovery and Climate Experiment (GRACE) And GRACE Follow‐On products with global models for the first time to analyze changes in water storages in this area from 2002 to 2020, and to investigate the effects of climate change and human activity on changes in water storage. We found that SNWDP‐ER aided the recovery of surface water (nongroundwater) with a recovery rate of 9.44 ± 1.65 mm/yr after its implementation, but had little effect on the recovery of groundwater and terrestrial water storage in the water‐receiving area. Before the SNWDP‐ER was implemented, the rates of decrease of groundwater and terrestrial water storage were only −1.59 ± 0.58 and −5.18 ± 0.75 mm/yr, respectively. After implementation, the rates of decrease of groundwater and terrestrial water storage were −17.7 ± 1.27 and −8.16 ± 1.18 mm/yr, respectively. Groundwater decline, accelerated by human activity and climate change, has led to an accelerated decline in terrestrial water storage. Effects of SNWDP‐ER and stringent policies reducing groundwater use, along with largely increased precipitation in North China on groundwater storage after year 2020 need to be examined in the future. Our results have important implications for the management and evaluation of SNWDP‐ER.
A Dual Inlet System for Laser Spectroscopy of Triple Oxygen Isotopes in Carbonate‐Derived and Air CO2
Authors: Bajnai David , Pack Andreas , Arduin Rode Fiorella , Seefeld Malte , Surma Jakub , Di Rocco Tommaso 
Published: October 2023

AbstractAnalyzing the triple oxygen isotope (Δ′17O) composition of carbonates and air CO2 can provide valuable information about Earth system processes. However, accurately measuring the abundance of the rare 17O‐bearing CO2 isotopologue using isotope ratio mass spectrometry presents significant challenges. Consequently, alternative approaches, such as laser spectroscopy, have been developed. Here, we describe an adaptable dual inlet system for a tunable infrared laser direct absorption spectrometer (TILDAS) that maintains stable instrumental conditions for subsequent sample and reference measurements. We report ∆′17O measurements on three types of samples: reference CO2, CO2 derived from the acid digestion of carbonates, and air CO2. The external repeatability (±1σ) for reference‐sample‐reference bracketing measurements is generally better than ±10 ppm, close to the average internal error of ±6 ppm. Our results demonstrate that laser spectroscopy is a capable technique for measuring triple oxygen isotopes with the precision required to resolve variations in the ∆′17O values of air CO2 and to use the ∆′17O of carbonates for paleothermometry.
The Stimulation Effect of Nitrogen‐Addition on Soil Nitrogen Leaching Weakens Over Time in an Alpine Forest
Authors: Peng Yuanrui , Wang Tao , Ao Jing , Liu Xinyu , Herath Saman , Chang Ruiying 
Published: October 2023

AbstractElevated anthropogenic nitrogen (N) input to headwater forests over the years increases soil N leaching and is expected to result in negative consequences like eutrophication of downstream regions. However, the long‐term response of N leaching to elevated N input in alpine forests remains elusive. Here, we explored the long‐term effects of the addition of N, as 15N‐labeled ammonium nitrate (15NH415NO3), on N leaching in a three‐N‐level experiment via a frequent sampling of soil leachates from two soil layers for eight years. The results showed that N addition increased the total dissolved N (TDN) concentrations and fluxes in leachates from the organic layer only for the high N addition (4 g N/m2/yr) treatment. Regardless of N treatment, dissolved organic N was the main leaching form of N. The effect of N addition on N leaching attenuated over time and it was partly attributed to the gradual increase in N retention by the aggrading forest. Overall, our data illustrate that N leaching showed declined trends over time due to the increased plants uptake, suggesting the important role of aggrading alpine forests in regulation of N leaching under elevated N deposition.
cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement
Authors: Mu Lianwei , Liu Xiaojie , Yu Hao , Vickstrom Casey R. , Friedman Vladislav , Kelly Thomas J. , Hu Ying , Su Wantang , Liu Shuai , Mantsch John R. , Liu Qing-song 
Published: October 2023

AbstractChronic cocaine exposure induces enduring neuroadaptations that facilitate motivated drug taking. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to modulate neuronal firing and pacemaker activity in ventral tegmental area (VTA) dopamine neurons. However, it remained unknown whether cocaine self-administration affects HCN channel function and whether HCN channel activity modulates motivated drug taking. We report that rat VTA dopamine neurons predominantly express Hcn3-4 mRNA, while VTA GABA neurons express Hcn1–4 mRNA. Both neuronal types display similar hyperpolarization-activated currents (Ih), which are facilitated by acute increases in cAMP. Acute cocaine application decreases voltage-dependent activation of Ih in VTA dopamine neurons, but not in GABA neurons. Unexpectedly, chronic cocaine self-administration results in enhanced Ih selectively in VTA dopamine neurons. This differential modulation of Ih currents is likely mediated by a D2 autoreceptor-induced decrease in cAMP as D2 (Drd2) mRNA is predominantly expressed in dopamine neurons, whereas D1 (Drd1) mRNA is barely detectable in the VTA. Moreover, chronically decreased cAMP via Gi-DREADD stimulation leads to an increase in Ih in VTA dopamine neurons and enhanced binding of HCN3/HCN4 with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b), an auxiliary subunit that is known to facilitate HCN channel surface trafficking. Finally, we show that systemic injection and intra-VTA infusion of the HCN blocker ivabradine reduces cocaine self-administration under a progressive ratio schedule and produces a downward shift of the cocaine dose-response curve. Our results suggest that cocaine self-administration induces an upregulation of Ih in VTA dopamine neurons, while HCN inhibition reduces the motivation for cocaine intake.
Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma
Authors: Li Zhenfen , Yang Ziyue , Zhu Yuanyuan , Fu Chunmeng , Li Ning , Peng Fang 
Published: October 2023

AbstractA high recurrence rate and easy metastasis are two prominent clinical features of hepatocellular carcinoma (HCC), which is also the most common cause of cancer-related death. However, the molecular pathogenesis of HCC remains unclear. Soluble resistance-related calcium-binding protein (Sorcin) is highly expressed in a variety of tumor cell lines and multidrug-resistant cell lines and participates in the malignant progression of tumors by regulating apoptosis. Pyroptosis is also a form of programmed cell death that plays a crucial role in exerting tumor suppression function and evoking anti-tumor immune responses. However, there is no consensus that Sorcin promotes HCC progression by regulating pyroptosis. Our study manifested that Sorcin was considerably upregulated, whereas pyroptosis-associated proteins were significantly decreased in HCC tissues and cells. Sorcin silencing attenuated the proliferation, migration, and invasion of HCC cells. Knockdown of Sorcin activates pyroptosis, and overexpression of Sorcin inhibits pyroptosis, yet has no significant effect on apoptosis, ferroptosis, and autophagy in HCC cells. Furthermore, coimmunoprecipitation and immunofluorescence assays revealed that Sorcin interacted with NLRP3 inflammasome to regulate pyroptosis in HCC cells. Then, the NLRP3 inhibitor MCC950 inhibited the activation of Sorcin knockdown-induced pyroptosis and reversed the effect of Sorcin silencing-induced weakening of malignant biological behavior in HCC. Similarly, suppression of Caspase-1 reversed the inhibitory effect of Sorcin knockdown on the malignant progression of HCC via knockdown of Caspase-1 or the inhibitor VX765. Consistent with the in vitro results, the nude mouse experiment showed that Sorcin knockdown inhibited the growth of HCC by activating pyroptosis, while Caspase-1 knockdown partially restored the growth inhibition caused by Sorcin knockdown. Collectively, high Sorcin expression in HCC negatively regulates pyroptosis by interacting with the NLRP3 inflammasome to promote HCC proliferation, migration, and invasion. The results of this study provide a scientific basis for Sorcin as a new biomarker and potential therapeutic target for HCC.
LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines
Authors: Wei Xiaoqian , Pan Shushan , Wang Zirui , Chen Jieru , Lu Li , Cao Qizhi , Song Shuling , Zhang Huachang , Liu Xiaohui , Qu Xianjun , Lin Xiukun , Xu Huanli 
Published: October 2023

AbstractLeukocyte-associated immunoglobulin-like receptor-1 (LAIR1), an immune receptor containing immunoreceptor tyrosine-based inhibiory motifs (ITIMs), has emerged as an attractive target for cancer therapy. However, the intrinsic function of LAIR1 in gliomas remains unclear. In this study, the poor prognosis of glioma patients and the malignant proliferation of glioma cells in vitro and in vivo were found to be closely correlated with LAIR1. LAIR1 facilitates focal adhesion kinase (FAK) nuclear localization, resulting in increased transcription of cyclin D1 and chemokines/cytokines (CCL5, TGFβ2, and IL33). LAIR1 specifically supports in the immunosuppressive glioma microenvironment via CCL5-mediated microglia/macrophage polarization. SHP2Q510E (PTP domain mutant) or FAKNLM (non-nuclear localizing mutant) significantly reversed the LAIR1-induced growth enhancement in glioma cells. In addition, LAIR1Y251/281F (ITIMs mutant) and SHP2Q510E mutants significantly reduced FAK nuclear localization, as well as CCL5 and cyclin D1 expression. Further experiments revealed that the ITIMs of LAIR1 recruited SH2-containing phosphatase 2 (SHP2), which then interacted with FAK and induced FAK nuclear localization. This study uncovered a critical role for intrinsic LAIR1 in facilitating glioma malignant progression and demonstrated a requirement for LAIR1 and SHP2 to enhance FAK nuclear localization.
Aberrant sense of agency induced by delayed prediction signals in schizophrenia: a computational modeling study
Authors: Okimura Tsukasa , Maeda Takaki , Mimura Masaru , Yamashita Yuichi 
Published: October 2023

AbstractAberrant sense of agency (SoA, a feeling of control over one’s own actions and their subsequent events) has been considered key to understanding the pathology of schizophrenia. Behavioral studies have demonstrated that a bidirectional (i.e., excessive and diminished) SoA is observed in schizophrenia. Several neurophysiological and theoretical studies have suggested that aberrancy may be due to temporal delays (TDs) in sensory-motor prediction signals. Here, we examined this hypothesis via computational modeling using a recurrent neural network (RNN) expressing the sensory-motor prediction process. The proposed model successfully reproduced the behavioral features of SoA in healthy controls. In addition, simulation of delayed prediction signals reproduced the bidirectional schizophrenia-pattern SoA, whereas three control experiments (random noise addition, TDs in outputs, and TDs in inputs) demonstrated no schizophrenia-pattern SoA. These results support the TD hypothesis and provide a mechanistic understanding of the pathology underlying aberrant SoA in schizophrenia.
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance
Authors: Guo Christina , Sharp Adam , Gurel Bora , Crespo Mateus , Figueiredo Ines , Jain Suneil , Vogl Ursula , Rekowski Jan , Rouhifard Mahtab , Gallagher Lewis , Yuan Wei , Carreira Suzanne , Chandran Khobe , Paschalis Alec , Colombo Ilaria , Stathis Anastasios , Bertan Claudia , Seed George , Goodall Jane , Raynaud Florence , Ruddle Ruth , Swales Karen E. , Malia Jason , Bogdan Denisa , Tiu Crescens , Caldwell Reece , Aversa Caterina , Ferreira Ana , Neeb Antje , Tunariu Nina , Westaby Daniel , Carmichael Juliet , Fenor de la Maza Maria Dolores , Yap Christina , Matthews Ruth , Badham Hannah , Prout Toby , Turner Alison , Parmar Mona , Tovey Holly , Riisnaes Ruth , Flohr Penny , Gil Jesus , Waugh David , Decordova Shaun , Schlag Anna , Calì Bianca , Alimonti Andrea , de Bono Johann S. 
Published: October 2023

AbstractInflammation is a hallmark of cancer1. In patients with cancer, peripheral blood myeloid expansion, indicated by a high neutrophil-to-lymphocyte ratio, associates with shorter survival and treatment resistance across malignancies and therapeutic modalities2–5. Whether myeloid inflammation drives progression of prostate cancer in humans remain unclear. Here we show that inhibition of myeloid chemotaxis can reduce tumour-elicited myeloid inflammation and reverse therapy resistance in a subset of patients with metastatic castration-resistant prostate cancer (CRPC). We show that a higher blood neutrophil-to-lymphocyte ratio reflects tumour myeloid infiltration and tumour expression of senescence-associated mRNA species, including those that encode myeloid-chemoattracting CXCR2 ligands. To determine whether myeloid cells fuel resistance to androgen receptor signalling inhibitors, and whether inhibiting CXCR2 to block myeloid chemotaxis reverses this, we conducted an investigator-initiated, proof-of-concept clinical trial of a CXCR2 inhibitor (AZD5069) plus enzalutamide in patients with metastatic CRPC that is resistant to androgen receptor signalling inhibitors. This combination was well tolerated without dose-limiting toxicity and it decreased circulating neutrophil levels, reduced intratumour CD11b+HLA-DRloCD15+CD14− myeloid cell infiltration and imparted durable clinical benefit with biochemical and radiological responses in a subset of patients with metastatic CRPC. This study provides clinical evidence that senescence-associated myeloid inflammation can fuel metastatic CRPC progression and resistance to androgen receptor blockade. Targeting myeloid chemotaxis merits broader evaluation in other cancers.