bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospun cobalt-doped 2D-MoSe2/polypyrrole hybrid-based carbon nanofibers as electrochemical sensing platforms
Authors: Celik Cogal Gamze , Cogal Sadik , Machata Peter , Uygun Oksuz Aysegul , Omastová Maria 
Published: January 2024

AbstractA novel cobalt-doped two-dimensional molybdenum diselenide/polypyrrole hybrid-based carbon nanofiber (Co/MoSe2/PPy@CNF) was prepared using the hydrothermal method followed by electrospinning technique. The structural and morphological properties of the 2D-TMD@CNF-based hybrids were characterized through X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), energy-dispersive spectrometry (EDS), and transmission electron microscopy (TEM). The Co-MoSe2/PPy@CNF exhibited large surface area, porous structure, and improved active sites due to the synergistic effect of the components. The electrochemical and electrocatalytic characteristics of the 2D-TMD@CNF-modified electrodes were also investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The Co/MoSe2/PPy@CNF electrode was used as an electrochemical sensor for simultaneous detection of ascorbic acid (AA), dopamine (DA), and uric acid (UA) and showed enhanced catalytic activity and sensitivity. Using DPV measurements, the Co/MoSe2/PPy@CNF demonstrated wide linear ranges of 30–3212 μM for AA, 1.2–536 μM for DA, and 10–1071 μM for UA with low detection limits of 6.32, 0.45, and 0.81 μM, respectively. The developed sensor with the Co/MoSe2/PPy@CNF-modified electrode was also applied to a human urine sample and gave recoveries ranging from 94.0 to 105.5% (n = 3) for AA, DA, and UA. Furthermore, the Co/MoSe2/PPy@CNF-based sensor exhibited good selectivity and reproducibility for the detection of AA, DA, and UA.
Graphical abstract
Spatially dependent veiling glare degrades image quality in medical extended reality
Authors: Zhao Chumin , Beams Ryan , Dahal Eshan , Badano Aldo 
Published: January 2024

AbstractSpatially dependent veiling glare in medical extended reality (MXR) degrades image quality and needs to be characterized across technologies. Measurement methods of veiling glare on virtual and augmented reality (VR and AR) head-mounted displays (HMDs) have not been established in regulatory evaluation of MXR devices or display measurement standards. We describe an experimental bench setup enabling highly flexible translations and rotations of the light measuring device in five degrees of freedom within the eye box. Glare point spread functions (PSFs) of multiple VR and AR headsets are extracted and compared across the display field of view (FOV) in dark environment. At the center, the evaluated VR headsets (HTC VIVE Pro and VIVE Pro 2) demonstrate reduced long-range glare compared to the tested AR HMDs (Microsoft HoloLens 2 and Epson Moverio BT-300). The measured PSFs at multiple locations are spatially invariant for the HoloLens 2. However, veiling glare on the evaluated VR HMDs substantially increases toward the periphery of the FOV primarily due to optical aberration. For VR devices in medical use, increased peripheral glare can lead to image quality degradation and poor visualization of anatomical details.
Direct Numerical Simulation of Vortex Breakdown in Evaporating Dilute Sprays
Authors: Liberatori Jacopo , Battista Francesco , Dalla Barba Federico , Ciottoli Pietro Paolo 
Published: January 2024

AbstractThe effects of different vortex breakdown states on the evaporation process characterizing air-acetone vapor swirling jets laden with liquid acetone droplets in the dilute regime are discussed based on results provided by direct numerical simulations. Adopting the point-droplet approximation, the carrier phase is solved using an Eulerian framework, whereas a Lagrangian tracking of the dispersed phase is used. Three test cases are investigated: one with fully-turbulent pipe inflow conditions and two with a laminar Maxworthy velocity profile at different swirl rates. Consequently, turbulent, bubble-type, and regular conical vortex breakdown states are established. Following phenomenological and statistical analyses of both phases, a significant enhancement of the overall droplet evaporation process due to the onset of the conical vortex breakdown is observed due to the strongest centrifugal forces driving the entire liquid drops towards the low-saturation mixing layer of the jet. The effects of droplet inertia on evaporation are isolated through an additional set of simulations where liquid droplets are treated as Lagrangian tracers. While it is found that inertial effects contribute to enhanced vaporization near the mixing layer under bubble vortex breakdown conditions, droplet inertia plays a secondary role under both turbulent and conical vortex breakdown due to intense turbulent mixing and high centrifugal forces, respectively.
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
Authors: Ferrucci Veronica , Lomada Santosh , Wieland Thomas , Zollo Massimo 
Published: January 2024

AbstractWe describe here the molecular basis of the complex formation of PRUNE1 with the tumor metastasis suppressors NME1 and NME2, two isoforms appertaining to the nucleoside diphosphate kinase (NDPK) enzyme family, and how this complex regulates signaling the immune system and energy metabolism, thereby shaping the tumor microenvironment (TME). Disrupting the interaction between NME1/2 and PRUNE1, as suggested, holds the potential to be an excellent therapeutic target for the treatment of cancer and the inhibition of metastasis dissemination. Furthermore, we postulate an interaction and regulation of the other Class I NME proteins, NME3 and NME4 proteins, with PRUNE1 and discuss potential functions. Class I NME1–4 proteins are NTP/NDP transphosphorylases required for balancing the intracellular pools of nucleotide diphosphates and triphosphates. They regulate different cellular functions by interacting with a large variety of other proteins, and in cancer and metastasis processes, they can exert pro- and anti-oncogenic properties depending on the cellular context. In this review, we therefore additionally discuss general aspects of class1 NME and PRUNE1 molecular structures as well as their posttranslational modifications and subcellular localization. The current knowledge on the contributions of PRUNE1 as well as NME proteins to signaling cascades is summarized with a special regard to cancer and metastasis.
The magnitude and direction of the relationship between risk factor and cognition depends on age: a pooled analysis of 5 community-based studies
Authors: Meirelles Osorio , Arnette Anthony , Guðnason Vilmundur , Launer Lenore J. 
Published: January 2024

AbstractThe mixed evidence of the association between high levels of cardiovascular risk factors (CVRF) and the risk for cognitive impairment may be due to confounding of age across studies. We pooled and harmonized individual-level data (30,967 persons, age range 42–96 years) from five prospective cohorts to investigate by 1 year age increments to investigate whether or not there is change in slope describing the association of CVRF to a cognitive outcome (Digit Symbol Substitution Test; DSST). The CVRF included: systolic and diastolic blood pressure, total cholesterol, fasting glucose and body mass index. Linear and quadratic piecewise regression models were fit to the trajectory patterns of these slopes (betas). The pattern of yearly slope changes showed higher CVRF were associated with lower DSST, but associations attenuated toward zero as age increased for all but DBP where 1 year slopes for DBP changed direction from negative to positive from mid- to late-age. Age is not only a driver of cognitive decline—age also modifies the direction and strength of the association of cognitive function to CVRF and cohort age may be one reason why the evidence for CVRF-CD association is mixed.
Designing a computer-vision-based artifact for automated quality control: a case study in the food industry
Authors: Xiong Felix , Kühl Niklas , Stauder Maximilian 
Published: January 2024

AbstractReducing waste through automated quality control (AQC) has both positive economical and ecological effects. In order to incorporate AQC in packaging, multiple quality factor types (visual, informational, etc.) of a packaged artifact need to be evaluated. Thus, this work proposes an end-to-end quality control framework evaluating multiple quality control factors of packaged artifacts (visual, informational, etc.) to enable future industrial and scientific use cases. The framework includes an AQC architecture blueprint as well as a computer vision-based model training pipeline. The framework is designed generically, and then implemented based on a real use case from the packaging industry. As an innovate approach to quality control solution development, the data-centric artificial-intelligence (DCAI) paradigm is incorporated in the framework. The implemented use case solution is finally tested on actual data. As a result, it is shown that the framework’s implementation through a real industry use case works seamlessly and achieves superior results. The majority of packaged artifacts are correctly classified with rapid prediction speed. Deep-learning-based and traditional computer vision approaches are both integrated and benchmarked against each other. Through the measurement of a variety of performance metrics, valuable insights and key learnings for future adoptions of the framework are derived.
Facet-dependent magnetic properties of magnetite nanoparticles coated with dodecyl amine and their biological effect in hepatocarcinoma cell line
Authors: Rojas-Aguirre Yareli , Rizo Juan , Martínez-Aguilera Miguelina , Rodríguez-Hernández Adriana , Díaz-Bello Beatriz , Vázquez-Victorio Genaro , Domínguez Héctor , Mendoza-Cruz Rubén , Betancourt Israel , Ortega-Galindo Saret , Guadarrama Patricia 
Published: January 2024

AbstractHerein was conducted a compelling structural analysis of magnetite nanoparticles (NPs) coated with dodecyl amine (DDA), compared with uncoated magnetite, both previously synthesized by an accelerated one-pot synthesis, starting from a single iron precursor. XRD/TEM results for the obtained nanomaterial Fe3O4@DDA showed the predominance of Fe3+ cations on the most stable atomic plane of magnetite (111). Using Molecular Dynamics calculations, with the observed atomic dispositions as inputs, it was established that NPs' surface and DDA might interact by short-distance coordination, with DDA as a ligand of Fe3+ cations, or by long-distance adsorption via H-bonding. The simulations align with TEM images, revealing an amorphous contour corresponding to the organic coating arranged as a bilayer. The TGA analysis corroborated a dual mass loss profile relating to the DDA bilayer at 116 °C and 350 °C. The Fe3O4@DDA NPs’ magnetic properties (saturation magnetization (Ms) and coercivity field (Hc)) were preserved. Fe3O4@DDA exhibited a reduction of 3 emu/g in Ms and an increment of 12 Oe in Hc, compared with Fe3O4 NPs, attributable to the coating inhomogeneity and the consequent anisotropy rise. Fe3O4@DDA triggered concentration-dependent cytotoxic effects on the human hepatocarcinoma cell line HepG2. At 50 µg/mL after incubation of 48 h, cell viability was 63% < , whereas at 72 h only 30% of cells were viable. At 300 µg/mL, less than 10% of HepG2 cells remained viable after 24 h of incubation. In the case of Fe3O4 NPs assessed in the same cell line, cell viability remained as high as 80% at 300 µg/mL during 72 h of incubation. Trypan blue assay suggests membrane integrity damage as the primary mechanism of HepG2 cell death. Even though the in vitro results herein presented are preliminary, they represent the first report of the cytotoxic effect of magnetite coated with a nitrogenous surfactant.
Graphical abstract
The potential of collaborative housing to tackle the social deficit of housing: the Chilean case
Authors: Cortés-Urra Valentina , Ersoy Aksel , Czischke Darinka , Gruis Vincent 
Published: January 2024

AbstractIn recent decades, various programs have been developed as part of Chile’s housing policies to respond to the housing deficit. Most policies have so far focused on addressing the quantitative, qualitative, and urban deficits, neglecting the social dimension of housing. At the same time, the concept of collaborative housing has been referred to as a possible alternative to respond to these social challenges by fostering social cohesion, collaboration, and mutual aid. This article explores how collaborative housing can tackle the social deficit of housing. Here, we conceptualise this deficit as ‘the lack of non-physical or intangible social characteristics given among residents of a project, such as trust, social cohesion, and a sense of community, necessary for housing to be considered adequate.’ We examined the relation between these two concepts by developing a theoretical and empirical study. The first consisted of a theoretical framework and a review of literature on collaborative housing’s response to the social deficit of housing. Second, we interviewed stakeholders from two study cases. We found that residents in both collaborative housing cases perceive an improvement in their social interactions, sociability, trust, and sense of community in their current homes compared to previous homes. Therefore, we conclude that collaborative housing presents opportunities to tackle the social deficit of housing.
Bevacizumab and gamma knife radiosurgery for first-recurrence glioblastoma
Authors: Zhang Jeff F. , Okai Bernard , Iovoli Austin , Goulenko Victor , Attwood Kristopher , Lim Jaims , Hess Ryan M. , Abad Ajay P. , Prasad Dheerendra , Fenstermaker Robert A. 
Published: January 2024

Abstract
Introduction
Glioblastoma (GBM) is the most common central nervous system malignancy in adults. Despite decades of developments in surgical management, radiation treatment, chemotherapy, and tumor treating field therapy, GBM remains an ultimately fatal disease. There is currently no definitive standard of care for patients with recurrent glioblastoma (rGBM) following failure of initial management.

Objective
In this retrospective cohort study, we set out to examine the relative effects of bevacizumab and Gamma Knife radiosurgery on progression-free survival (PFS) and overall survival (OS) in patients with GBM at first-recurrence.

Methods
We conducted a retrospective review of all patients with rGBM who underwent treatment with bevacizumab and/or Gamma Knife radiosurgery at Roswell Park Comprehensive Cancer Center between 2012 and 2022. Mean PFS and OS were determined for each of our three treatment groups: Bevacizumab Only, Bevacizumab Plus Gamma Knife, and Gamma Knife Only.

Results
Patients in the combined treatment group demonstrated longer post-recurrence median PFS (7.7 months) and median OS (11.5 months) compared to glioblastoma patients previously reported in the literature, and showed improvements in total PFS (p=0.015), total OS (p=0.0050), post-recurrence PFS (p=0.018), and post-recurrence OS (p=0.0082) compared to patients who received either bevacizumab or Gamma Knife as monotherapy.

Conclusion
This study demonstrates that the combined use of bevacizumab with concurrent stereotactic radiosurgery can have improve survival in patients with rGBM.
Macroscale structural changes of thylakoid architecture during high light acclimation in Chlamydomonas reinhardtii
Authors: Broderson Mimi , Niyogi Krishna K. , Iwai Masakazu 
Published: January 2024

AbstractPhotoprotection mechanisms are ubiquitous among photosynthetic organisms. The photoprotection capacity of the green alga Chlamydomonas reinhardtii is correlated with protein levels of stress-related light-harvesting complex (LHCSR) proteins, which are strongly induced by high light (HL). However, the dynamic response of overall thylakoid structure during acclimation to growth in HL has not been fully understood. Here, we combined live-cell super-resolution microscopy and analytical membrane subfractionation to investigate macroscale structural changes of thylakoid membranes during HL acclimation in Chlamydomonas. Subdiffraction-resolution live-cell imaging revealed that the overall thylakoid structures became thinned and shrunken during HL acclimation. The stromal space around the pyrenoid also became enlarged. Analytical density-dependent membrane fractionation indicated that the structural changes were partly a consequence of membrane unstacking. The analysis of both an LHCSR loss-of-function mutant, npq4 lhcsr1, and a regulatory mutant that over-expresses LHCSR, spa1-1, showed that structural changes occurred independently of LHCSR protein levels, demonstrating that LHCSR was neither necessary nor sufficient to induce the thylakoid structural changes associated with HL acclimation. In contrast, stt7-9, a mutant lacking a kinase of major light-harvesting antenna proteins, had a slower thylakoid structural response to HL relative to all other lines tested but still showed membrane unstacking. These results indicate that neither LHCSR- nor antenna-phosphorylation-dependent HL acclimation are required for the observed macroscale structural changes of thylakoid membranes in HL conditions.
Digitization and the Shaping of Society – A Soft Systems Study
Authors: Stowell Frank 
Published: January 2024

Abstract The ubiquity of communication technologies has influenced the way we receive and process ‘information’. It is shaping the way that human societies interact and made it to distinguish between tittle-tattle and facts. Despite its many benefits it can also lead to social disengagement where ‘data’ is treated as information and ‘news’ can be untrue. In this paper I investigate if digitization is changing the nature of society and the way we behave. Using a Soft systems method, I explore the impact that digitization is having upon society and discuss the lessons learnt. The suggestion is made that using soft ideas might help receivers to gain a better appreciation of the material they access within the context in which it is expressed.
Pregnancy, a test case for immunology
Authors: Devanesan Arjun 
Published: January 2024

AbstractThe traditional conception of immune function is that of a system which differentiates the organism’s own tissues (the self) from any foreign invaders (nonself), preserving the former by rejecting the latter. In a mammalian pregnancy, however, the immunologically foreign foetus is accepted by the gestator’s immune system. This presents a serious challenge to the self–nonself theory which has sometimes been called the immunological paradox of pregnancy. In this paper I shall defend the self–nonself theory against the critique posed by Thomas Pradeu. In addition I critically examine the alternative he proposes—the continuity theory. The main problem I will raise for any theory of immunology is that the phenomenon to be explained in pregnancy is the non-rejection of the foetus despite the triggering of the gestator’s immune system. I will argue that contemporary modified versions of the self–nonself theory can rise to this challenge but that continuity theory cannot. As such, the immunology of pregnancy gives us a good reason to favour contemporary self–nonself theory over the continuity theory.
Inductive Metaphysics Versus Logical Construction—Russell’s Methods and Realisms in 1912 and 1914
Authors: Seide Ansgar 
Published: January 2024

AbstractIn his 1912 book The Problems of Philosophy, Bertrand Russell advocates an indirect realism with regard to physical objects. Only two years later, in his book Our Knowledge of the External World and the paper “The Relation of Sense-Data to Physics”, he changes his method in philosophy. Instead of inferring the existence of physical objects, he now sets out to construct them out of sense-data. As I will argue in this article, the main argument from The Problems of Philosophy can be rationally reconstructed as an inference to the best explanation which infers to unobservable objects. The main motivation for the new approach in Our Knowledge of the External World, on the other hand, is to establish a more direct variant of realism, in particular because Russell became skeptical with regard to inferences to unobservable objects. As I will argue, the resulting theory of the physical world loses so much in simplicity that it becomes an unattractive alternative to his earlier position, and Russell’s reason for rejecting simplicity as a criterion of theory choice turns out to be inconsequential.
Variation in the use of anthropogenic materials in tit nests: influence of human activities and pandemic restrictions
Authors: Girão Joana , Bessa Filipa , Garrido-Bautista Jorge , Ferreira Beatriz , Santos-Baena Carolina , Marques M. Paula M. , Batista de Carvalho Luís A. E. , Ramos Jaime Albino , Norte Ana Cláudia 
Published: January 2024

AbstractAs urbanization expands, so does the presence of anthropogenic materials within bird’s nests. However, our understanding of this phenomenon remains limited, particularly in terrestrial birds. This study describes and compares the use of anthropogenic materials in great tit (Parus major) and blue tit (Cyanistes caeruleus) nests in relation to the intensity of anthropogenic activities, distance to contamination sources and reproductive metrics, in nest boxes in a suburban wood in Coimbra, Portugal, during the breeding seasons of 2020 and 2021. Nests were collected after fledging and sorted to remove anthropogenic materials. From a total of 9.71% anthropogenic materials in great tit nests we observed an abundance of uncoloured tangles of mixed fibres, representing 78% of the total weight of the anthropogenic materials in great tit nests in 2021. The chemical composition of these mixtures was determined by spectroscopy analysis, using Fourier transform infrared spectroscopy (FTIR), and 56% of the nests (16/25) contained fibres from synthetic origin. The percentage of anthropogenic materials was higher in great tit than in blue tit nests and increased in 2021, comparatively to 2020. The proximity to potential contamination sources influenced positively the percentage of anthropogenic materials in nests, as those closer to areas with more intense anthropogenic activities (the bar/tennis court and the wastewater treatment plant) had a higher percentage of these materials. No effects on productivity were detected. Our results suggest that the use of these materials is probably related to the intensity of anthropogenic activities.