bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Low or High Physical Activity Level Does Not Modulate Prostate Tumor Tissue Protein Synthesis Rates
Authors: Houben Lisanne H. P. , Tuytten Tom , Holwerda Andrew M. , Wisanto Erika , Senden Joan , Wodzig Will K. W. H. , Olde Damink Steven W. M. , Beelen Milou , Beijer Sandra , van Renterghem Koenraad , van Loon Luc J. C. 
Published: December 2023

ABSTRACTIntroductionPhysical activity level has been identified as an important factor in the development and progression of various types of cancer. In this study, we determined the impact of a low versus high physical activity level on skeletal muscle, healthy prostate, and prostate tumor protein synthesis ratesin vivoin prostate cancer patients.MethodsThirty prostate cancer patients (age: 66 ± 5 y, BMI: 27.4 ± 2.9 kg per m2) were randomized to a low (<4000 steps per day,n= 15) or high (>14000 steps per day,n= 15) physical activity level for seven days prior to their scheduled radical prostatectomy. Daily deuterium oxide administration was combined with the collection of plasma, skeletal muscle, non-tumorous prostate, and prostate tumor tissue during the surgical procedure to determine tissue protein synthesis rates throughout the intervention period.ResultsDaily step counts averaged 3610 ± 878 and 17589 ± 4680 steps in patients subjected to the low and high physical activity level, respectively (P< 0.001). No differences were observed between tissue protein synthesis rates of skeletal muscle, healthy prostate, or prostate tumor between the low (1.47 ± 0.21, 2.74 ± 0.70, and 4.76 ± 1.23 % per day, respectively) and high (1.42 ± 0.16, 2.64 ± 0.58, and 4.72 ± 0.80 % per day, respectively) physical activity group (allP> 0.4). Tissue protein synthesis rates were nearly twofold higher in prostate tumor compared with non-tumorous prostate tissue.ConclusionsA short-term high or low physical activity level does not modulate prostate or prostate tumor protein synthesis ratesin vivoin prostate cancer patients. More studies on the impact of physical activity level on tumor protein synthesis rates and tumor progression are warranted to understand the potential impact of lifestyle interventions in the prevention and treatment of cancer.
Causal relationship between Helicobacter pylori antibodies and gastroesophageal reflux disease (GERD): A mendelian study
Authors: Chen Jiaqin , Zhang Junning , Ma Xiaolu , Ren Yuehan , Tang Yi , Zhang Zhongmian , Ye Wangyu , Zhang Xiyan , Lin Zili , Wang Lan , Li Zhihong 
Published: December 2023

BackgroundObservational studies have indicated that both Helicobacter pylori infection and the presence of Helicobacter pylori antibodies may increase the risk of gastroesophageal reflux disease (GERD). However, the exact association between Helicobacter pylori antibodies and the occurrence of GERD remains largely unresolved. Therefore, this two-sample Mendelian randomization (MR) study aims to investigate the causal relationship between Helicobacter pylori infection and GERD.MethodsThis study encompassed seven different specific protein antibodies targeting Helicobacter pylori and utilized a genome-wide association study (GWAS) on GERD. MR analysis was conducted to assess the causal relationship between Helicobacter pylori antibodies and the development of GERD.ResultsGenetically predicted serum levels of Helicobacter pylori IgG antibodies were positively associated with an increased risk of GERD (odds ratio [OR] = 1.001, 95% CI 1.000–1.003, P = 0.043). No causal relationship was found between other Helicobacter pylori antibodies and gastroesophageal reflux disease.ConclusionThe outcomes derived from our two-sample Mendelian randomization analysis demonstrate a discernible link between the levels of Helicobacter pylori IgG antibodies and an augmented susceptibility to GERD. However, it is imperative to expand the sample size further in order to corroborate the correlation between Helicobacter pylori infection and GERD.
Adenomyosis in women undergoing hysterectomy for abnormal uterine bleeding associated with uterine leiomyomas
Authors: Lonky Neal M. , Chiu Vicki , Portugal Cecilia , Estrada Erika L. , Chang John , Fischer Heidi , Vora Jamie B. , Harrison Lawrence I. , Peng Lauren , Munro Malcolm G. 
Published: December 2023

Background
Uterine leiomyomas and adenomyosis are both common and often associated with abnormal uterine bleeding (AUB), including the symptom of heavy menstrual bleeding (HMB). Understanding the prevalence of adenomyosis in women with uterine leiomyomas could inform clinicians and patients in a way that may improve therapeutic approaches.

Objective
To explore the prevalence of adenomyosis in a group of women who underwent hysterectomy for AUB-L, to determine the prevalence of submucous leiomyomas, and to examine the utility of preoperative ultrasound to detect the presence of adenomyosis.

Methods
The Kaiser Permanente Hysterectomy Database (KPHD) was searched for women aged 18–52 undergoing hysterectomy for leiomyoma-associated chronic AUB (AUB-L) in 2018 and 2019. A target sample of 400 comprised those with at least 3 years in the Health System. Radiologists evaluated preoperative pelvic ultrasound images to determine leiomyoma size and level 2 FIGO type (submucous or other), and the linked electronic medical record abstracted for clinical features, including histopathological evidence of adenomyosis.

Results
Of the 370 subjects that met the study criteria, adenomyosis was identified via histopathology in 170 (45.9%). There was no difference in the adenomyosis prevalence with (47.1%) and without (43.0%) at least one submucous leiomyoma. Subgroup analysis of ultrasound images by an expert radiologist for the presence of adenomyosis demonstrated a positive predictive value of 54.0% and a negative predictive value of 43.4%.

Conclusions
Adenomyosis was present in almost half of this AUB-L cohort undergoing hysterectomy and was equally prevalent in those with and without submucous leiomyomas as determined by sonographic evaluation. The imaging findings are in accord with prior investigators and demonstrate that 2-D ultrasound is insensitive to the presence of adenomyosis when the uterus is affected by leiomyomas. Further research is necessary to determine the impact of various adenomyosis phenotypes on the presence and severity of the symptom of HMB.
INNOVATIVE AND INVESTMENT ACTIVITIES OF DOMESTIC ENGINEERING: STATUS AND TRENDS
Authors: Askanova O. V. 
Published: December 2023

In today’s reality, Russia’s technological vulnerability problem requires an urgent solution. Therefore, intensifying investment and innovation activities in the mechanical engineering sector, the main system-forming sector of the economy, is crucial for the survival of our country. The author recognizes the close interdependence of investment and innovation processes and aims to conduct a comparative and correlation analysis based on official data from the Federal State Statistics Service for one type of activity related to mechanical engineering.
The study reveals that the crisis in Russian engineering, which began in the 1990s, is ongoing, with extremely low levels of innovation and investment. These factors are insufficient for the technical and technological re-equipment of the country’s machine-building sector. Additionally, the depreciation of partially and completely worn-out equipment exacerbates the crisis.
The author believes that the development of mechanical engineering and related sectors in the Russian economy can only occur when the ruling elites implement a radical change in the direction of state policy. This change should prioritize the integrated use of state support measures to systematically address the identified problem. The author emphasizes that such a change in policy should follow a rhetoric of innovation and investment by the ruling elites.
OPTIMIZATION OF THE PROCESS OF PROVIDING THE COMPANY WITH SPECIAL SHOES BASED ON DATA ON ITS ISSUANCE AND INDICATORS OF IMPRORER PLANNING
Authors: Senchenko V. A. , Kaverzneva T. T. 
Published: December 2023

Timely and full provision of employees of enterprises with personal protective equipment is an important task in the occupational health and safety management system. Since the costs of large companies for the purchase of PPE amount to impressive amounts, companies seek to optimize costs by centralizing purchases and purchasing PPE at wholesale prices. As a result of centralized purchases, the purchase price of a unit of goods decreases, however, a number of problems arise when planning purchases related to the variety of anthropometric data of employees of the enterprise and the time lag for the supply of products.
This article discusses the problems and approaches to solving them when providing employees with personal protective equipment for their feet (special shoes) on the example of PJSC «RTK». The data on the issue of shoes from the warehouse for 3 years are given, reflecting the picture of the deficit and surplus of the demand for standard sizes of the shoe range at the enterprise. Attempts have been made to analyze the available data array. Possible reasons and indicators of incorrect planning (provision) of PPE are formulated. Approaches to further development of optimization of PPE planning are proposed.
A Theoretical Analysis of Collusion Involving Technology Licensing Under Diseconomies of Scale
Authors: Lindblom Ted , Mallios Aineas , Sjögren Stefan 
Published: December 2023

Abstract
This study focuses on firms with cost-efficient technology that use licensing to influence product market behaviour, market prices and outputs and the resulting welfare effects. We show how licensing fees can be constructed that lead to identical collective industry outputs as under collusion while industry output is equal to or higher than that achieved under competition and sustained in equilibrium. Hence, consumers are either indifferent to firms’ collusion or better off when they do collude, whereas firms (producers) are always better off due to the improved cost efficiency of integrating the new production technology. This provides a theoretical foundation that explains why technology licensing is observed in highly concentrated industries characterised by significant diseconomies of scale relative to demand. We contribute to the literature by demonstrating how technology licensing involving collusion can reduce the dissipation effect and improve social welfare in oligopolistic industries. An important policy implication is that collusion involving technology licensing should not always be challenged by antitrust authorities, particularly when it does not transfer welfare from consumers to producers.
The Effectiveness of Online Problem-Based Learning Tasks on Riyadh’s Secondary School Students’ Problem-Solving Ability and Programming Skills
Authors: Alshaye Ibrahim Abdullah , Tasir Zaidatun , Jumaat Nurul Farhana 
Published: December 2023

AbstractThis study aims to examine the effectiveness of online problem-based learning (PBL) tasks on problem-solving ability (PSA) and programming skills of secondary school students. A quantitative research design of a quasi-experimental research was adopted in this study. A purposive non-random sampling method was used to select two schools. Then, a clustered random sampling technique was carried out to select four classes, consisting of 120 students. The classes were divided equally into online PBL and non-online PBL. A problem-solving inventory questionnaire was used to measure PSA before and after the treatment, and pre-post performance tests were used to assess students’ performance. The students underwent 8 weeks of learning tasks by using online PBL via Facebook groups. The findings from this study proved that online PBL improved students’ PSA, and their higher-order thinking skills, and helped them to perform better in learning programming by using Facebook for interaction and participation in the online discussion with a facilitator and peers.
Influence of inlet structure on combustion flow structure in magnesium powder fueled water ramjet engine
Authors: Xu Wei , Yang Zhi-Long , Wu Yun-Kai , Ding Guo-Yu , Xue Rui , Liu Jun-Li , Sun Hai-Jun 
Published: December 2023

Abstract
Different inlet structures have a significant impact on the internal flow characteristics of a solid-magnesium powder water ramjet engine. Based on the magnesium-water reaction model, a computational fluid dynamics (CFD) method is applied to establish a numerical simulation method for the internal flow field of the engine, and the internal flow characteristics of the engine under different inlet structure conditions are studied. The simulation results show that high-temperature gas can effectively promote the ignition of magnesium powder at the top of the combustion chamber, while accelerating the evaporation of the first inlet water and increasing the combustion rate of magnesium powder. The secondary inlet has the most significant effect on the temperature inside the combustion chamber. When the secondary inlet flow rate increases towards the top of the combustion chamber, it increases the amount of heat absorbed by the evaporating water at the top of the chamber, thereby reducing the temperature at the top of the combustion chamber. However, when the flow rate is low, it results in insufficient oxidizer at the top of the combustion chamber, which is unfavorable for the combustion of magnesium powder.
Healing the Hauntings: A Discourse Analysis of Grief in Two-Spirit Poetry
Authors: Bradley Mónica 
Published: December 2023

This paper provides a discourse analysis of two poems selected from the book Sovereign Erotics: A Collection of Two-Spirit Literature (Driskill et al., 2011b) to explore the concept of grief in Two-Spirit/Queer Indigenous poetry. It analyzes the diction, voice, formality, themes, metaphors, similes, personification, and the use of repetition the authors utilize to represent grief and discover the social, cultural, and political realities and discursive practices behind the poems. It concludes that through their expression of grief, the poets highlight the emergence and endurance of a community and people who will continue to fight for survival and the right to live in peace and harmony outside of colonial gender and sexual binaries. Both poems engage with a continuing sense of Two-Spirit identity that call forth new generations of Queer Indigenous/Two-Spirit people while remembering their history and the Elders who came before to heal personal and historical trauma often through connection with nature, their ancestors, and spirituality.
National eye health data from the Hungary's Comprehensive Health Protection Screening Program 2010–2020–2030 (MÁESZ)
Authors: Németh J. , Nagy Z. Z. , Tapasztó B. , Daiki T. , Dankovics G. , Barna I. 
Published: December 2023

AbstractPurposeThis paper provides a detailed presentation of the estimated number of people in Hungary with eye disease and refractive errors by both sex and age.Materials/methodsIn the past 12 years, 168,522 people (54.1% women and 45.9% men) have been screened under Hungary's Comprehensive Health Protection Screening Programme (MÁESZ).ResultsThe total number of people with eye disease in the adult Hungarian population (about 8 million people) is estimated to be 1,684,818, with women (1,078,026) outnumbering men (606,792). Eye diseases were found to be more common in older age groups, and more common in women than men in each age group. The estimated number of people with refractive errors in the Hungarian adult population is 5,005,095. The overall number of people with myopia in the adult Hungarian population is estimated to be 3,058,536, with roughly equal numbers of men and women. The majority of people with myopia (63.3%) are between 18 and 45 years of age.ConclusionsThe huge number of people in the Hungarian population affected by eye disease or refractive errors underscores the need to develop and implement an effective national strategy and specific programmes to prevent visual impairments.
Pentingnya Pelayanan Kefarmasian secara Daring sebagai Konsekuensi Adanya Penerapan Physical Distancing saat Pandemi Covid-19 di Jawa Timur
Authors: Susanto Leonard , Setyoningrum Oktaviani  , Siti Rahmaniah Sekaryadi  , Vina Aulia Tri Andriana  , Nurul Usmia  , , Esti Rahayuningtyas  , Hendrayanti Haniyah Putri  , Brigitta Alvina Kumalasari  , Dyan Churniawan Syaputra  , Steven Guitomo  , Atikah Luthfiyyah Sari  , Bagus Dwi Zufar  , Nadhifa Hanunnisa  , Qonita Zulfa Rachmawati  , Wahyu Utami  
Published: December 2023

Coronavirus disease (Covid-19) pertama kali ditemukan pada tahun 2019 di Kota Wuhan, Tiongkok. Penyebaran virus yang masif membuat organisasi kesehatan dunia (WHO) menyatakan wabah Covid-19 sebagai pandemi. Hal tersebut membawa perubahan dalam kehidupan bersosial akibat adanya kewajiban untuk menjaga jarak termasuk dalam mendapatkan pelayanan kefarmasian. Pelayanan kefarmasian secara daring dapat menjadi solusi dari adanya pembatasan sosial yang diterapkan selama pandemi. Penelitian ini bertujuan untuk mengetahui cara komunikasi masyarakat dalam mendapatkan pelayanan kefarmasian di masa pandemi dengan menerapkan physical distancing, mengetahui pelayanan kefarmasian yang dirasakan selama penerapan physical distancing, serta memberikan edukasi dalam rangka peningkatan pemahaman masyarakat jawa timur terhadap pelayanan kefarmasian secara daring. Berdasarkan klasifikasi menurut tujuannya, penelitian ini tergolong sebagai penelitian deskriptif yang menggunakan pendekatan kuantitatif. Data didapatkan melalui survei menggunakan teknik random sampling. Penelitian ini melibatkan 223 responden yang merupakan masyarakat Jawa Timur dengan mayoritas usia 21 tahun. Dari hasil penelitian diketemukan bahwa responden memiliki pengetahuan terkait physical distancing yang baik (98,2%) namun kurangnya kesadaran untuk mengimplementasikannya. Dalam pelayanan kefarmasian, responden merasakan adanya perubahan akibat penerapan pembatasan sosial saat pandemi. Sebagian besar responden memiliki ketertarikan untuk menggunakan pelayanan kefarmasian secara daring (82.96%) jika tersedia. Sebanyak 29,15% dari total responden pernah menggunakan pelayanan kefarmasian secara daring. Umumnya pelayanan didapatkan melalui aplikasi kesehatan (54,95%) dan whatsapp (35,16%) dengan frekuensi pemakaian yang rendah (1-2 kali dalam 6 bulan terakhir). Responden yang pernah menggunakan pelayanan kefarmasian secara daring memiliki intensi untuk memanfaatkannya kembali di masa yang akan datang. Namun, tidak semua apotek menyediakan layanan tersebut. Sehingga edukasi pelayanan kefarmasian menjadi penting untuk dilakukan guna mendukung penerapan physical distancing di masa pandemi COVID-19 ini.
Keyakinan dan Motivasi Remaja Putri di Surabaya untuk Melakukan Vaksinasi HPV
Authors: Sihab Fawaz , Hafsyah Nisriena Wijdan , Arifianto Rahmat , Azizah Karisma Nor , Natalie Rachel , Edhi Narendrani Sasmitaning , Putri Azzahra Sefiansyah Nabila , Mailana Pinta Achutiara , Bazzam Gabriellatifah , Albariqy Muhammad Atras , Sukorini Anila Impian 
Published: December 2023

Kanker serviks adalah penyakit menular seksual yang disebabkan oleh Human Papilloma Virus (HPV) . Kanker serviks berisiko tinggi tertular pada remaja berusia 15-16 tahun. Vaksinasi HPV dilakukan untuk pencegahan penyebaran kanker serviks. Penelitian ini menggunakan teori Health Belief Model (HBM) dengan tujuan untuk mengidentifikasi keyakinan dan motivasi remaja putri di Surabaya untuk melaksanakan vaksinasi HPV. Metode pengambilan sampel yang dilakukan adalah accidental sampling dengan 103 sampel remaja putri berusia 17-25 tahun yang berdomisili di Surabaya. Mayoritas responden berusia 20-22 tahun dengan riwayat tingkat pendidikan terakhir SMA dan sebanyak 98,1% berstatus belum menikah. Pada teori HBM, sebanyak 93,2% responden meyakini bahwa keparahan penyakit kanker serviks dapat menyebabkan kematian dan 87,3% responden berinisiatif melakukan vaksinasi HPV karena khawatir dengan akibat terkena kanker serviks. Adanya dukungan orang tua dan pemberian informasi terkait pelaksanaan vaksinasi HPV dapat mempengaruhi motivasi untuk melakukan vaksinasi. Hal ini menunjukkan bahwa upaya penyebaran informasi dan peningkatan keyakinan perlu dilakukan kepada remaja putri beserta keluarganya guna meningkatkan motivasi melakukan vaksinasi HPV.
Pengetahuan dan Tindakan Penyimpanan Obat pada Keluarga di Kelurahan Mulyorejo
Authors: Princesa Renata Anindya Mubarok  , Kadek Ayu Happy Calista Nova  , Renata Diva Erifiannisa  , Mar’atun Qonyta  , Miftahul Nabighoh Kuswardahningrum  , Sitya Fibriani  , Alya Az Zahro  , Nurlaili  , Agung Bagus Nugroho  , Anila Impian Sukorini  
Published: December 2023

Penyimpanan obat yang tidak tepat berpengaruh terhadap kualitas obat. Di Indonesia, persentase rumah tangga yang menyimpan obat untuk swamedikasi cukup besar. Berdasarkan penelitian, masyarakat seringkali tidak memperhatikan ketentuan yang seharusnya dilakukan dalam penyimpanan obat. Penelitian ini bertujuan untuk mengidentifikasi tingkat pengetahuan dan tindakan penyimpanan obat pada keluarga di kawasan Kelurahan Mulyorejo, Surabaya. Desain penelitian secara observasional dengan metode cross-sectional dan pemilihan sampel secara convenience sampling. Kriteria inklusi responden yaitu keluarga di RT 3, RW 1 Kecamatan Mulyorejo Kelurahan Mulyorejo yang sedang menyimpan obat. Sebelum pengambilan data, responden telah mengisi informed consent. Sebanyak 84 sampel memenuhi kriteria penelitian. Data diambil dengan kuesioner dan lembar observasi lalu dianalisis secara statistik deskriptif menggunakan program IBM SPSS 25. Hasil penelitian menunjukan terdapat 2 responden (2,4%) dengan kategori pengetahuan rendah, 41 responden (48,8%) kategori sedang, dan 41 responden (48,8%) kategori tinggi. Dilihat dari tindakan penyimpanan 278 obat, sebanyak 86 obat (30,9%) disimpan pada kotak obat dan 192 obat (69,1%) disimpan di tempat lain. Hasil dari penelitian menunjukkan bahwa pengetahuan masyarakat tidak sejalan dengan tindakan penyimpanan obat yang benar karena masyarakat masih kurang mempraktikan pengetahuan yang dimiliki terkait penyimpanan obat dengan benar yang dapat berdampak pada kesehatan diri dan lingkungan. Oleh karena itu masyarakat perlu diberikan edukasi yang lebih lanjut mengenai penyimpanan obat yang benar dan juga kebijakan publik yang menekankan kepada penyimpanan obat yang benar.
Profil Farmakoepidemiologi Suplemen Penambah Darah dan Pengukuran Kualitas Hidup pada Ibu Hamil di UPT Puskesmas Kecamatan Kongbeng Kabupaten Kutai Timur
Authors: Lujuk Herlina , Clara Ritawany Sinaga  , Wiwi Erwina  
Published: December 2023

Kualitas kesehatan anak yang dikandung sangat dipengaruhi asupan gizi dan kesehatan ibunya. Penelitian ini bertujuan untuk mendiskripsikan profil penggunaan sumplemen penambah darah (jenis dan pola konsumsi;, efek terapi dan efek sampingnya; pengetahuan, sikap dan tindakan terhadap pentingnya mengkonsumsi suplemen penambah darah; dan untuk mengetahui kualitas hidup ibu hamil di Puskesmas Kecamatan Kongbeng Kabupaten Kutai Timur. Penelitian ini merupakan jenis penelitian deskriptif dengan rancangan penelitian cross-sectional. Penelitian ini menggunakan teknik total sampling. Pengambilan data menggunakan metode observasi, wawancara dan lembar kuesioner EQ-5D-5L selama bulan Mei – Juni 2023 pada ibu hamil di wilayah kerja Puskesmas Kecamatan Kongbeng. Teknik analisis data yaitu analisis univariat deskriptif, pola konsumsi suplemen penambah darah, pengetahuan, sikap dan tindakan dalam mengkonsumsi suplemen penambah darah dan kualitas hidup. Hasil dari penelitian ini diperoleh 70 responden ibu hamil yang mengkonsumsi kombinasi tablet zat besi, dan asam folat sebanyak 77,4 %. Terdapat 87,14 % ibu hamil yang tidak mengalami anemia berdasarkan kadar Hb. Mayoritas ibu hamil merasakan efek samping mual atau muntah (45,71%). Terdapat 72,86 % ibu hamil yang memiliki pengetahuan kurang baik, 78,57 % sikap ibu hamil baik, dan 67,86 % tindakan yang kurang baik. Indeks utilitas ibu hamil yang diukur dengan kuesioner kualitas hidup EQ-5D-5L menunjukkan hasil 0,861 0,155.