bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Traditional Boundaries: Exploring Vertical Bifacial Photovoltaic System Efficiency
Authors: Badran Ghadeer , Dhimish Mahmoud 
Published: February 2024

Abstract

This paper presents the first comprehensive study of a groundbreaking Vertically Mounted Bifacial Photovoltaic (VBPV) system, marking a significant innovation in solar energy technology. The VBPV system, characterized by its vertical orientation and the use of high-efficiency Heterojunction (HJT) cells, introduces a novel concept diverging from traditional solar panel installations. Our empirical research, conducted over a full year at the University of York, UK, offers an inaugural assessment of this pioneering technology. The study reveals that the VBPV system significantly outperforms both a vertically mounted monofacial PV (VMPV) system and a conventional tilted monofacial PV (TMPV) system in energy output. Key findings include a daily power output increase of 7.12% and 10.12% over the VMPV system and an impressive 26.91% and 22.88% enhancement over the TMPV system during early morning and late afternoon hours, respectively. Seasonal analysis shows average power gains of 11.42% in spring, 8.13% in summer, 10.94% in autumn, and 12.45% in winter compared to the VMPV system. Against the TMPV system, these gains are even more substantial, peaking at 24.52% in winter. These results underscore the VBPV system's exceptional efficiency in harnessing solar energy across varied environmental conditions, establishing it as a promising and sustainable solution in solar energy technology.
Bone loss and osteosarcopenia induced by aromatase inhibitor treatment in elderly patients with breast cancer: the role of intervention with inhibitors of RANK/RANKL system
Authors: casabella andrea , Paladin Francesca , ottaviani silvia , Marelli Cristina , Ponzano Marta , Signori Alessio , Paolino Sabrina , Cutolo Maurizio , Molfetta Luigi , Nencioni Alessio , Murdaca Giuseppe , Monacelli Fiammetta 
Published: February 2024

Abstract

This study explores the efficacy of desonumab in mitigating aromatase inhibitor-induced bone loss (AIBL) and osteosarcopenia in elderly women with breast cancer. The study involved 60 patients (female sex > or equal 65) with non-metastatic breast cancr and undegoing adiuvant endocreine therapy (Letrozole and Tamoxifen). Patients were divided as follows: 30 patients undergoing denosumab therapy (60 mg via subcutaneous injection every 6 months) and 30 patients undergoing bisphosphonate therapy (oral alendronate 70 mg/week). For each patient of the desonumab group bone status and muscoloskeletal composition was assessed by bone densitometry together with comprehensive geriatric assessment (CGA) and body composition at baseline and after one year of treatment. A significant improvement for trabecular bone score (TBS) at hte lumbar spine, relative skeletal muscle index (RSMI) and whole-body composition (arm, legs and trunk) were observed in the desonumab group compared with the bisphopshonate group. These findings underscore the role of desonumab as an effective strategy in managing AIBL and osteosarcopenia in elderly women with breast cancer and undergoing adjuvant endocrine therapy, which is crucial for improving quality of life, preventing functional decline, and optimizing treatment outcomes
Differences in Sleep EEG Coherence and Spindle Metrics in Toddlers With and Without Language Delay: A Prospective Observational Study
Authors: Hong Xinyi , Farmer Cristan , Kozhemiako Nataliia , Holmes Gregory L , Thompson Lauren , Manwaring Stacy , Thurm Audrey , Buckley Ashura 
Published: February 2024

Abstract

Background: Sleep plays a crucial role in early language development, and sleep disturbances are common in children with neurodevelopmental disorders. Examining sleep microarchitecture in toddlers with and without language delays can offer key insights into neurophysiological abnormalities associated with atypical neurodevelopmental trajectories and potentially aid in early detection and intervention.
Methods: Here, we investigated electroencephalogram (EEG) coherence and sleep spindles in 16 toddlers with language delay (LD) compared with a group of 39 typically developing (TD) toddlers. The sample was majority male (n = 34, 62%). Participants were aged 12-to-22 months at baseline, and 34 (LD, n=11; TD, n=23) participants were evaluated again at 36 months of age.
Results: LD toddlers demonstrated increased EEG coherence compared to TD toddlers, with differences most prominent during slow-wave sleep. Within the LD group, lower expressive language skills were associated with higher coherence in REM sleep. Within the TD group, lower expressive language skills were associated with higher coherence in slow-wave sleep. Sleep spindle density, duration, and frequency changed between baseline and follow-up for both groups, with the LD group demonstrating a smaller magnitude of change than the TD group. The direction of change was frequency-dependent for both groups.
Conclusions: These findings indicate that atypical sleep EEG connectivity and sleep spindle development can be detected in toddlers between 12 and 36 months and offers insights into neurophysiological mechanisms underlying the etiology of neurodevelopmental disorders.
Trial registration: https://clinicaltrials.gov/study/NCT01339767; Registration date: 4/20/2011
Attitude of Tabriz University of Medical Sciences students towards research
Authors: Mahmoodi Firooz , Beheshti Hannaneh 
Published: February 2024

Abstract
Introduction: Research is essential for societal development and medical sciences. Medical schools should train researchers and promote a research culture. This study assessed the attitude of medical students at Tabriz University of Medical Sciences (TUOMS) towards research.
Methods: A cross-sectional descriptive design was used to collect data from 268 randomly selected medical students. A questionnaire adapted from Sobczuk et al. measured their attitude towards research. Data analysis was performed using one-sample and Friedman statistical tests in SPSS 26 software.
Results: The results indicated that the students had a positive attitude towards research, but lacked motivation and participation. They rated logical thinking and scientific contribution as the most important aspects of research attitude. The main barriers to conducting research were knowledge gap and financial problem.
Conclusion: The findings suggest that the students are interested in research, but need more support and guidance. The university should offer courses on research methods, increase awareness of research importance and benefits, provide facilities and resources, and enhance attention from officials and professors.
Using Small Area Estimation to Produce Reliable Transportation Statistics: The Case of Household Trips Estimation at The Census Tract Level
Authors: Al-Khasawneh Mohammad B. , Cirillo Cinzia 
Published: February 2024

Abstract

This paper proposes Small Area Estimation (SAE) methods on linked datasets to generate reliable transportation statistics in cases where data on travel behavior is limited or missing. Specifically, household person trips are estimated at the census tract by linking data from the Regional Travel Survey (RTS), the American Community Survey (ACS), and US Census 2020 data. The proposed SAE modeling framework integrates direct and synthetic estimations to produce accurate statistics. Several small area estimation techniques have been employed, including regression-based models and population synthesis for areas with zero samples, as well as the Fay-Herriot model for areas with small samples. For the regression-based models, we assessed several models, including linear, Poisson, negative binomial, and random forest models, using cross-validation analysis. The Fay-Herriot method is also applied to improve estimation precision by combining direct and synthetic estimation approaches. Results showed the proposed methodology's effectiveness in generating reliable estimates in both cases of missing or limited samples. The research highlights the potential of SAE methods in enhancing transportation analysis by integrating diverse datasets and reducing the survey data collection burden. These findings have practical implications for researchers, policymakers, and transportation planners seeking reliable estimates for smaller domains and subgroups using existing data sources.
Deep-Learning Methods for Efficient Real-Time Droplet Tracking in Crop-Spraying Systems
Authors: Huynh Truong Nhut , Nguyen Kim-Doang 
Published: February 2024

Abstract

Spray systems in agriculture serve essential roles in the precision application of pesticides, fertilizers, and water, contributing to effective pest control, nutrient management, and irrigation. These systems enhance efficiency, reduce labor, and promote environmentally friendly practices by minimizing chemical waste and runoff. The efficacy of a spray is largely determined by the characteristics of its droplets, including their size and velocity. These parameters are not only pivotal in assessing spray retention, i.e. how much of the spray adheres to crops versus becoming environmental runoff, but also in understanding spray drift dynamics. This study introduces a real-time deep-learning-based approach for droplet detection and tracking, which significantly improves the accuracy and efficiency of measuring these droplet properties. Our methodology leverages advanced AI techniques to overcome the limitations of previous tracking frameworks, employing three novel deep-learning-based tracking methods. These methods are adept at handling challenges like droplet occlusion and varying velocities, ensuring precise tracking in real-time potentially on mobile platforms. The use of a high-speed camera, operating at 2000 frames per second, coupled with innovative automatic annotation tools, enables the creation of a large, accurately labeled droplet dataset for training and evaluation. The core of our framework lies in the ability to track droplets across frames, associating them temporally despite changes in appearance or occlusions. We utilize metrics including Multiple Object Tracking Accuracy (MOTA) and Multiple Object Tracking Precision (MOTP) to quantify the tracking algorithm's performance. Our approach is set to pave the way for innovations in agricultural spraying systems, offering a more efficient, accurate, and environmentally responsible method of applying sprays. This is a significant step toward sustainable agricultural practices.
Condensation of membrane receptors can be controlled via specific adhesion to supported lipid bilayers with nanoscale topography
Authors: Hu Jinglei , Li Long , Hou Ruihan , Shi Xinghua , Ji Jing , Różycki Bartosz , Song Fan 
Published: February 2024

Abstract

Developing physical methods to modulate biomolecular clusters and condensates on cell membranes is of great importance for understanding physiological and pathological processes as well as for stimulating novel therapeutic strategies. Here, we propose an effective means to control biomolecular condensation on the cell membrane via specific adhesion to a supported lipid bilayer (SLB) with nanoscale topography. The specific adhesion is mediated by receptors in the cell membrane that bind their ligands anchored in the SLB. Using Monte Carlo simulations and mean-field theory, we demonstrate that the nanoscale topography of the SLB can enhance condensation of the receptors associated with lipid microdomains. This enhancement originates from (i) an interplay between the receptor-ligand binding and membrane bending, (ii) an effective attraction between the receptor-ligand complexes induced by thermal undulations of the membrane, and (iii) a rigidity difference between the membrane matrix and lipid microdomains. Our results indicate that SLBs with nanoscale topography proves an effective physical stimulus for tuning condensation of membrane adhesion proteins and lipids in cell membranes, and can serve as a feasible option to control and direct cellular activities, e.g., stem cell differentiation for biomedical and therapeutic applications.
RETRACTED: OTUB1 Regulates Ferroptosis to Inhibit Myoblast Differentiation into Myotubes by Deubiquitinating P62
Authors: Wei Limin , Li Yanhong , Tan Helin , Peng Yue , Liu Qian , Zheng Tingting , Li Feng , Xu Zhongxian 
Published: February 2024

Abstract
The authors have requested that this preprint be removed from Research Square.
Uncertain prelabor rupture of membranes at term and associated delivery outcomes
Authors: Geron Yossi , Negrin Noam Rozner , Matot Ran , Hendin Natav , Danieli-Gruber Shir , Shmueli Anat , Hadar Eran 
Published: February 2024

Abstract

Background
Prelabor rupture of membranes (PROM) is a common obstetrical event, but its diagnosis is frequently challenging. The aim of the study was to determine whether equivocal PROM cases are associated with adverse outcomes.
Methods
A retrospective study was conducted in a tertiary medical center between July 2012 and March 2022. The cohort consisted of women diagnosed with term PROM (≥ 37 gestational weeks), divided into two groups: (1) certain PROM - suggestive history of a watery vaginal discharge confirmed by visualization of fluid leaking from the cervix or pooling in the vagina on speculum examination; (2) uncertain PROM - suggestive history of a watery vaginal discharge not supported by speculum examination. All patients were hospitalized and gave birth spontaneously or following either expectant management for up to 24 hours from PROM or induction. The primary outcome measure was cesarean delivery rate. Secondary outcome measures were adverse maternal and neonatal events.
Results
A total of 2012 women were included in the study, 1750 with certain PROM and 262 with uncertain PROM. The cesarean delivery rate was 5.8% in the certain PROM group and 8.8% in the uncertain PROM group; the difference was not statistically significant (p = .074). There was a significant between-group difference in the rate of cesarean delivery due to failed induction on univariate analysis (0.69% vs 2.67%, respectively, p = .007), but it was not maintained on multivariate logistic regression (OR 0.37, 95% CI 0.117–1.172). Other maternal and neonatal outcomes were similar in the two groups.
Conclusions
In our study, following the same management guidelines for equivocal cases of ruptured membranes as for confirmed cases of term PROM did not compromise maternal or fetal outcomes.
Oxaliplatin-induced peripheral neuropathy with hepatic arterial versus intravenous infusion in metastatic colorectal cancer.
Authors: VALERY Marine , Tanguy Marie Laure , Gelli Maximiliano , Smolenschi Cristina , Hollebecque Antoine , Boileve Alice , de Sevilla Elena Fernandez , Tselikas Lambros , Bonnet Baptiste , Goere Diane , Taieb Julien , Boige Valérie , Ducreux Michel , Malka David 
Published: February 2024

Abstract

Background – Oxaliplatin, a major drug in metastatic colorectal cancer (mCRC), is responsible for a cumulative, dose-limiting peripheral neuropathy (PN). Whether the hepatic arterial infusion (HAI) route can limit oxaliplatin-induced PN in comparison with intravenous (IV) route has not been specifically explored so far. Methods – We compared the frequency and severity of PN in oxaliplatin-naive patients with mCRC included in trials that evaluated treatment with oxaliplatin administered either by HAI (ACCORD 04, CHOICE, OSCAR, and PACHA-01 trials) or by IV route (FFCD 2000-05 trial). We retrieved anonymized, prospectively collected data from trial databases for the ACCORD 04, CHOICE and FFCD 2000-05 trials; and through a review of Gustave Roussy patients’ electronic medical records for PACHA-01 and OSCAR trials. The primary endpoint was the incidence of clinically significant PN (grade 2 to 4) according to the cumulative dose of oxaliplatin received. Secondary endpoints were time to onset of neuropathy as a function of the cumulative dose of oxaliplatin, discontinuation of oxaliplatin for neurotoxicity, and safety. Results – 363 patients were included (IV, 300; HAI, 63). 180 patients in the IV group (60%) and 30 patients in the HAI group (48%) developed clinically significant PN, with no significant difference between the two groups (p = 0.23). No difference was shown in the time to onset of PN, neither (p = 0.23). Conclusion – The administration of oxaliplatin HAI rather than IV in the treatment of mCRC does not seem to reduce the incidence, precocity and severity of PN.
Effect of freez thaw on the solubility the Mesozoic limestone (a case study: Iran, Dorfak karstic area, Guilan province, North of Iran)
Authors: Dehban Maryam , Ghobadi Mohammad Hossein , Mohseni Hasan 
Published: February 2024

Abstract

The present study attempts to survey the Dorfak karstic area in the Guilan province (north of Iran) in terms of engineering geology. To reach of purpose, was collected sample of four lithological unites. Laboratory tests were done to determinate physical, chemical and mechanical properties. Examining the value of softening and freezing coefficients vs. the value of solubility and solubility rate constant shows adversely relation between three variables. Also, any significant relationship wasn’t observed between these coefficients and the solubility rate constant values in samples exposed to 60 freezing-thawing cycles. Because the internal area increasing of porosity due to freezing-thawing cycles was non-calculable for the determination of the solubility rate constant. To investigate the effects of the specific surface area on the value of solubility, SEM images of the samples was prepared in different modes. The study of the effects of the specific surface area in the dissolution process shows that with increasing the specific surface area, the value of calcium ions dissolved in the water in both cases (primary types and Cir. After F-T samples) has increased. Also, by plotting the solubility rate constant value in both cases before and after 60 freezing-thawing cycles vs. the specific surface area was proved that with increasing the specific surface area, the solubility rate constant value in the primary types (P) has increased. In samples after freezing-thawing cycles (Cir. After F-T), solubility rate constant values decreased with an increasing specific surface area. Because the rise of in the area created in these samples due to freezing-thawing cycles was non-calculable for the determination of the solubility rate constant.
Multi-Modal Human Action Recognition in videos using LSTM with Feature Fusion
Authors: Bharathi A. , Sri M. 
Published: February 2024

Abstract
Over past few decades, Human action recognition (HAR) in RGB-Depth videos has been extensively studied on the availability of economical depth sensors. Presently, unimodal methods such as skeleton-based and RGB video-based have achieved significant advancements by utilizing progressively larger amounts of data. Nevertheless, there has been a challenge of extracting the temporal feature in RGB video, spatial feature in skeleton sequence. To solve this challenge, we propose Skeleton-RGB Feature Fusion LSTM (SRF-LSTM) network to combine the skeleton and RGB stream modalities and to recognize actions. The fusion of RGB video and skeleton sequences capture both temporal and spatial information effectively. The proposed SRF-LSTM model performs better with an average accuracy of 90.4% than state-of-the-art techniques on NTU RGB-D dataset.
Carbon beam transmission therapy reverses iron deposits and microglia-driven neuroinflammation and induces cognitive improvement in an Alzheimer’s disease mouse model.
Authors: Lee Won-Seok , Choi Younshick , Kokubo Toshiaki , Hamano Tsuyoshi , Zaboronik Alexander , Ishikawa Takasaki , Chang Won-Seok , Kim EunHo , Kim Jong-Ki 
Published: February 2024

Abstract
Background
Insoluble iron deposits often exist as iron oxide nanoparticles in protein aggregates, impaired ferritin, or activated microglia, and have been implicated as a major culprit of neuroinflammation in Alzheimer’s disease. However, no crucial evidence has been reported to support the therapeutic effects of current iron chelators on the deposition of various molecular forms of insoluble iron.
Methods
We investigated the therapeutic effect of carbon ion stimulation (CIS) via the use of a transmission beam on insoluble iron deposits and the associated biological response in AD mouse brains.
Results
Compared no treatment, CIS dose-dependently induced a 33–60% reduction in the amount of ferrous-containing iron species and associated inclusion bodies in the brains of AD mice. CIS induced considerable neuroinflammation downregulation and conversely anti-inflammatory upregulation, which was associated with improved memory and enhanced hippocampal neurogenesis.
Conclusions
In conclusion, our results suggest that the effective degradation of insoluble iron deposits in combination with pathogenic inclusion bodies plays a role in promoting AD-modifying properties and offers a potential carbon ion treatment option for AD.
GWAS and transcriptomic analysis identify OsRING315 as a new candidate gene controlling amylose content and gel consistency in rice
Authors: Nie Shuai , Chen Luo , Zheng Minhua , Dong Jingfang , Ma Yamei , Zhou Lian , Wang Jian , Chen Jiansong , Hu Haifei , Yang Tifeng , Zhao Junliang , Zhang Shaohong , Yang Wu 
Published: February 2024

Abstract

Background
Cooking quality is the main factor determining the market value of rice. Although several major genes and a certain number of QTLs controlling cooking quality have been identified, the genetic complexity and environmental susceptibility limit the further molecular breeding for cooking quality improvement.
Results
This research conducted a genome-wide association study to elucidate the QTLs related to cooking quality including amylose content (AC), gel consistency (GC) and alkali spreading value (ASV) by using 450 rice accessions consisting of 300 indica and 150 japonica accessions in two distinct environments. A total of 54 QTLs were identified, including 25 QTLs for AC, 12 QTLs for GC and 17 QTLs for ASV. Among them, 10 QTLs were consistently observed by the same population in both environments. Six QTLs were co-localized with the reported QTLs or cloned genes. The Wx gene for AC and GC, and ALK gene for ASV were identified in every population across the two environments. The qAC9-2 for AC and the qGC9-2 for GC were defined to the same interval. The OsRING315 gene, encoding an E3 ubiquitin ligase, was considered as the candidate gene for both qAC9-2 and qGC9-2. The higher expression of OsRING315 corresponded to the lower AC and high GC. Three haplotypes of OsRING315 were identified. The Hap 1 mainly existed in the japonica accessions and had lower AC. The Hap 2 and Hap 3 were predominantly present in the indica accessions, associated with higher AC. Meanwhile, the GC of accessions harboring Hap 1 was higher than that of accessions harboring Hap 3. In addition, the distribution of the three haplotypes in several rice regions was unbalanced.
Conclusion
The three traits of cooking quality are controlled by both major and minor genes and susceptible to environmental factors. The expression level of OsRING315 is related to AC and GC, and this gene can be a promising target in quality improvement by using the gene editing method. Moreover, the haplotypes of OsRING315 differentiate between indica and japonica, and reveal the differences in GC and AC between indica and japonica rice.