bluuebunny/crossref_metadata_2025_split huggingface dataset:
NLRP12 is a prognostic biomarker and correlated with immune infiltrates in epithelial ovarian cancer
Authors: Ma Ruiqiong , Tang Zhijian , Wang Jianliu 
Published: November 2023

AbstractBackgroundNLRP12 is a member of the intracellular Nod‐like receptor (NLR) family, suggesting it is an innate immune receptor for the initiation and progression of several cancers. However, its role on prognosis and immune infiltrates in epithelial ovarian cancer (EOC) is still unknown. The present study aimed to evaluate its prognostic value and its association with immune infiltrates in EOC.MethodsThe mRNA expression of NLRP12 of EOC from The Cancer Genome Atlas (TCGA) was analyzed. The association between NLRP12 and clinicopathological characters was evaluated with logistic regression. The association between NLRP12 expression and survival was analyzed by Cox regression and Kaplan–Meier analyses. A nomogram was used to predict the impact of NLRP12 on prognosis. Gene Ontology term analysis and gene set enrichment analysis (GSEA) were performed to identify the signaling pathways related to NLRP12 expression. Immune cells infiltration for NLRP12 was analyzed using single‐sample GSEA. The relationship between NLRP12 and tumor‐infiltrating immune cells (TICs) was investigated by a Wilcoxon rank sum test. The expression of NLRP12 were also further verified in EOC tissues and cell lines. Additionally, we confirmed the biological function of NLRP12 in vitro.ResultsNLRP12 was highly expressed in patients with EOC from TCGA. High NLRP12 expression correlated with poor disease‐specific survival (p < 0.001) and overall survival (p < 0.001). Multivariate analysis revealed that NLRP12 expression was an independent prognostic marker for overall survival (p = 0.042). The C‐indexes and calibration plots of the nomogram based on multivariate analysis indicated an effective predictive performance for EOC patients. GSEA showed enrichment of cell adhesion, tumorigenesis and immune response in the NLRP12 high expression group. Increased NLRP12 expression correlated positively with several TICs, including macrophages, neutrophils, T effector memory cells and immature dendritic cells (p < 0.001). In addition, NLRP12 silencing inhibited cell proliferation and migration in EOC cells.ConclusionsIn conclusion, increased NLRP12 expression correlated significantly with poor survival and immune infiltration in EOC.
Real‐world experiences of atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma in Hong Kong
Authors: Yiu Dorothy C. Y. , Chan Brandon L. H. , Wong Alex C. F. , Feng Maple Y. , Chan Stephen L. 
Published: November 2023

AbstractBackground and AimsThe IMbrave150 trial established atezolizumab–bevacizumab as the new standard of care for hepatocellular carcinoma (HCC). However, evidence on its applications in real‐world patients is limited. We report the efficacy and safety of atezolizumab–bevacizumab in a Chinese cohort of HCC patients ineligible for clinical trials.MethodsElectronic medical records of patients diagnosed with HCC and with pharmacy orders of atezolizumab and bevacizumab between 2019 and 2021 were retrospectively reviewed. Patients' demographics, performance status, stage, treatment received, adverse events and death time (if any) were recorded.ResultsThirteen eligible patients were included. mOS of HCC patients was 18.6 months [6.8–30.4], while mPFS was 9.3 months [0–19.4]. No grade 5 adverse events were reported.ConclusionsThis real‐world study provides real‐world experiences of atezolizumab–bevacizumab as first‐line and subsequent therapy in patients with unresectable HCC. Further validation on the efficacy and safety of atezolizumab–bevacizumab as second‐line or later lines of treatment should be conducted.
Effects of energy loads on energy and nutrient absorption rates and gut microbiome in humans: A randomized crossover trial
Authors: Yoshimura Eiichi , Hamada Yuka , Hatamoto Yoichi , Nakagata Takashi , Nanri Hinako , Nakayama Yui , Hayashi Takanori , Suzuki Ippei , Ando Takafumi , Ishikawa‐Takata Kazuko , Tanaka Shigeho , Ono Rei , Park Jonguk , Hosomi Koji , Mizuguchi Kenji , Kunisawa Jun , Miyachi Motohiko 
Published: November 2023

AbstractObjectiveThis study aimed to determine the effects of different energy loads on the gut microbiota composition and the rates of energy and nutrient excretion via feces and urine.MethodsA randomized crossover dietary intervention study was conducted with three dietary conditions: overfeeding (OF), control (CON), and underfeeding (UF). Ten healthy men were subjected to each condition for 8 days (4 days and 3 nights in nonlaboratory and laboratory settings each). The effects of dietary conditions on energy excretion rates via feces and urine were assessed using a bomb calorimeter.ResultsShort‐term energy loads dynamically altered the gut microbiota at the α‐diversity (Shannon index), phylum, and genus levels (p < 0.05). Energy excretion rates via urine and urine plus feces decreased under OF more than under CON (urine −0.7%; p < 0.001, urine plus feces −1.9%; p = 0.049) and UF (urine −1.0%; p < 0.001, urine plus feces −2.1%; p = 0.031). However, energy excretion rates via feces did not differ between conditions.ConclusionsAlthough short‐term overfeeding dynamically altered the gut microbiota composition, the energy excretion rate via feces was unaffected. Energy excretion rates via urine and urine plus feces were lower under OF than under CON and UF conditions.
Study of the influence of PPS, PAEK, and PEEK thermoplastic matrices on the static mechanical behavior of carbon fiber‐reinforced composites
Authors: Osti de Moraes Dijan Vinicius , de Melo Morgado Guilherme Ferreira , Magnabosco Rodrigo , Rezende Mirabel Cerqueira 
Published: November 2023

AbstractThe growing use of poly(phenylene sulfide) (PPS), poly(aryl ether ketone) (PAEK), and poly(ether ether ketone) (PEEK) polymers reinforced with carbon fiber (CF) aims to meet the increasing demand for structural thermoplastic composites in applications that require excellent mechanical properties and thermal stability at higher temperatures (for example, above 120°C). The present work studied the influence of semicrystalline thermoplastic matrices of PPS, PAEK, and PEEK on the static mechanical behavior of CF‐reinforced composites through tensile tests and fractographic analysis of the respective fracture surfaces. The results of mechanical tests showed that the matrix influenced the static properties of the composites, mainly in stiffness, highlighting the CF/PEEK composite with the highest stiffness (42.3 ± 0.5 GPa) and the CF/PPS with the lowest standard deviation in tensile strength (599 ± 12 MPa). The fractographic analyses showed the good quality of the laminates, which presented an excellent matrix‐reinforcement interface, without fiber detachment or pulling out after mechanical tests, guaranteeing the transfer of efforts from the matrix to the reinforcement.Highlights
Static mechanical behavior of structural composites with thermoplastic matrix.
Static tensile tests of CF/PPS, CF/PEEK, and CF/PAEK composites were performed.
Influence of semicrystalline matrices on the mechanical behavior of composites.
Mechanical behavior of CF‐reinforced composites with PEEK, PAEK, and PPS.
Fractographic analyses of the fracture surfaces of thermoplastic composites.
“Highly nuanced policy is very difficult to apply at scale”: Examining researcher account and content takedowns online
Authors: Zelin Aaron Y. 
Published: November 2023

AbstractSince 2019, researchers examining, archiving, and collecting extremist and terrorist materials online have increasingly been taken offline. In part a consequence of the automation of content moderation by different technology companies and national governments calling for ever quicker takedowns. Based on an online survey of peers in the field, this research highlights that up to 60% of researchers surveyed have had either their accounts or content they have posted or stored online taken down from varying platforms. Beyond the quantitative data, this research also garnered qualitative answers about concerns individuals in the field had related to this problem set, namely, the lack of transparency on the part of the technology companies, hindering actual research and understanding of complicated and evolving issues related to different extremist and terrorist phenomena, undermining potential collaboration within the research field, and the potential of self‐censorship online. An easy solution to this would be a whitelist, though there are inherent downsides related to this as well, especially between researchers at different levels in their careers, institutional affiliation or lack thereof, and inequalities between researchers from the West versus Global South. Either way, securitizing research in however form it evolves in the future will fundamentally hurt research.
Communicating with LGBTQ+ persons at end of life: A case‐based analysis of interdisciplinary palliative clinician perspectives
Authors: Rosa William E. , McDarby Meghan , Buller Haley , Ferrell Betty R. 
Published: November 2023

AbstractObjectiveLesbian, gay, bisexual, transgender, and queer or questioning (LGBTQ+) persons with serious illness and their families often experience end‐of‐life (EOL) care disparities, such as homophobia and transphobia, disrespect and mistreatment, and exclusion of significant others or life partners. The aim of the study was to explore interdisciplinary clinicians’ communication knowledge and priorities using a case of a gay man at EOL and his same‐sex, cisgender spouse.MethodsInterdisciplinary clinicians (n = 150) who participated in a national 3‐day communication training program, rooted in Adult Learning Theory and supported by the National Cancer Institute, responded to open‐ended questions about a composite case study emphasizing diversity challenges relevant to LGBTQ + communities in the EOL context. A thematic analysis of responses using an iterative, inductive approach was conducted until saturation was reached.ResultsParticipants from nursing (48%), social work (35%) and chaplaincy (17%) responded to the survey. Five themes emerged: 1) provision of patient‐centered care; 2) legal and ethical factors inform care and decision making; 3) considerations of same‐sex spouse or couple context; 4) dynamics and role of family of origin; and 5) elements of inclusive clinical care.ConclusionsLGBTQ + inclusive communication training is essential for all palliative clinicians to deliver culturally safe care. Our findings have implications for identifying unconscious bias, addressing discriminatory care, filling clinician knowledge gaps, and informing educational interventions to support LGBTQ + inclusion. Future research must focus on micro‐ and macro‐level communication issues that shape the quality of palliative and EOL care for patients and chosen family members.
The psychological impact of sarcoma on affected patients
Authors: Franzoi Isabella Giulia , Granieri Antonella , Sauta Maria Domenica , Agnesone Monica , Gonella Marco , Grimaldi Carola , Vallauri Irene , Boglione Antonella , Vana Federica , Bergnolo Paola , Comandone Alessandro 
Published: November 2023

AbstractObjectiveSarcoma diagnosis and its treatment trajectory may deeply affect the somatopsychic balance of patients and their caregivers. This systematic review aimed at deepening the understanding of sarcoma's impact on the entire family unit involved in the illness experience on a physical (e.g. fatigue), psychological (e.g. mental health, affective regulation, defense mechanisms), and interpersonal (e.g. social isolation, loneliness) level.MethodsThe systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. The literature search led to the identification and subsequent inclusion of 44 articles focused on sarcoma patients. Results were classified into seven categories: Quality of Life, worries and distress, anxiety and depression, suicide ideation, financial and occupational consequences, unmet needs, and coping strategies. Our search identified only one study focusing on informal caregivers, thus we could not perform a systematic review on these results.ResultsOur findings underlined the traumatic impact of the sarcoma diagnosis. Patients can experience an impoverished emotional life, somatization, social withdrawal, difficulty in decision‐making, increased feelings of discouragement and demoralization, and profound experiences of helplessness and vulnerability. Moreover, they seemed to display anxiety and depression and might present a higher suicide incidence than the general population.ConclusionOur review highlighted that the psychosocial aftermath of sarcoma patients should guide institutions and healthcare professionals toward the design of assessment and intervention models that could contemplate the different dimensions of their suffering. Furthermore, it points out that there is still a lack of evidence regarding the psychosocial impact affecting sarcoma patients' caregivers.
Reappraising personal values in cancer: Meaning‐in‐life adaptation, meaningfulness, and quality of life
Authors: Carreno David F. , Eisenbeck Nikolett , Uclés‐Juárez Rubén , García‐Montes José Manuel 
Published: November 2023

AbstractObjectiveThis study explores the reappraisal of personal values among people with cancer post‐diagnosis and its connections to meaningfulness, encompassing personal meaning and sense of meaning, and various dimensions of quality of life.MethodsA total of 144 patients with diverse cancer types and a control group comprising 158 healthy adults with similar demographic characteristics completed the Valued Living Questionnaire‐Perceived Change, the Personal Meaning Profile‐Brief, the Portrait Values Questionnaire, and the Functional Assessment of Chronic Illness Therapy‐Spiritual Well‐Being.ResultsCancer patients displayed a substantial values reappraisal compared to healthy adults. They reported an increased significance of social areas and self‐transcendental values, including close relationships (family, partner, and friends), spirituality, citizenship, and universalism, as well as an increased importance of self‐care and self in general. Conversely, cancer patients assigned less importance to work and self‐enhancement values such as stimulation, power, and achievement. Cluster analysis revealed that patients who reappraised their values exhibited higher meaningfulness and better indicators of quality of life, including spiritual and physical well‐being, compared to patients who did not modify their value system.ConclusionsThese findings underscore the importance of assessing and promoting meaning‐in‐life adaptability among people with cancer, with potential applications in meaning‐centered therapies and interventions aimed at enhancing psychological flexibility.
The 2022 monkeypox outbreak 1 year on: The 5 Ws
Authors: Khan Gulfaraz , Perveen Nighat 
Published: November 2023

AbstractIn May 2022, World Health Organization (WHO) reported an outbreak of Mpox in several European countries which were previously Mpox free. Mpox (formerly known as monkeypox) is a zoonotic viral disease endemic in Central and West Africa. The sudden emergence of Mpox outside Africa and its subsequent rapid spread lead the WHO to declare the outbreak as Public Health Emergency of International Concern. By 15 May 2023, a total of 87,704 confirmed cases and 140 deaths had been reported from 111 countries and territories worldwide. Looking back on this outbreak 1 year later, several important questions have arisen. Here, we address these questions using the classic 5 Ws: What, When, Where, Who and Why? We discuss these questions to understand how this outbreak emerged and how it was effectively managed. We outline what needs to be done to prevent, or at least minimise, outbreaks due to emerging and re‐emerging viral infections.
Corporate governance for sustainability: Connecting environmental, social and economic goals
Authors: Bhat Basit Ali , Makkar Manpreet Kaur , Gupta Nitin 
Published: November 2023

AbstractThis paper examines corporate governance's influence on corporate Sustainability in South Asian firms. Recent developments in social injustice, environmental issues and economic turmoil in South Asian countries have motivated the authors. The study used the GMM unbalanced panel data estimation on top South Asian listed firms. The time‐period of the sample taken is of ten years (2012–2022). This study reveals that among South Asian nations, companies listed in the Indian and Bangladesh stock markets have a high percentage of sustainability disclosure reporting. The study's findings show that Board size, independence, and qualification positively impact environmental sustainability reporting performance. In contrast, CEO Duality significantly negatively influences social, environmental, and economic sustainability. The study has implications for the companies and policymakers of South Asian countries and encouraged the firms to restructure the board to enhance its effectiveness to monitor better and support all aspects of corporate sustainability.
A sense of risk: Responses to crowdfunding risk disclosures
Authors: Shrestha Prabal , Thewissen James , Arslan‐Ayaydin Özgür , Parhankangas Annaleena 
Published: November 2023

AbstractResearch SummaryThis paper examines how reward‐based crowdfunding backers respond to risk disclosures. Combining theoretical frameworks from financial accounting with the risk perception literature, we adopt an abductive research approach to explore various nuances that influence backers' tolerance for risk information. In addition to identifying the general dynamics in backers' risk interpretation, we highlight the complexities introduced by differences in the disclosure's semantic content, expressed feelings, and the discloser's background attributes. Relying on a hierarchical Bayesian mixture model, we first identify a positive curvilinear relationship between risk information quantity and crowdfunding success. We then demonstrate the influences of what is disclosed, how it is disclosed, and who discloses it, while emphasizing the context‐bound specificities of individual project types.Managerial SummaryOur study aids entrepreneurs to effectively communicate risks in reward‐based crowdfunding campaigns. We consistently find that entrepreneurs provided substantially less risk information than the optimum amount of information, emphasizing the need for more extensive disclosures. On what to disclose, backers favored information on risks that are consequential to them personally and not those that affect the entrepreneur's project. On how to disclose, expressed feelings had little influence on how much risk information backers preferred. However, who provides the disclosure was crucial, as trust‐enhancing factors increased backers' appetite for risk information. Together, our findings show that, while communicating risks, entrepreneurs should be cognizant that online backers undertake calculative evaluations and have material motivations. Furthermore, our category level results aid entrepreneurs in making practical judgments on context‐specific deviations across project types.
Differences in resilience profiles between military veterans and the general population: An exploratory latent profile analysis using the HUNT‐4 survey
Authors: Nordstrand Andreas Espetvedt , Bøe Hans Jakob , Hjemdal Odin , Huffman Ann Hergatt , Noll Laura Katherine , Reichelt Jon Gerhard , Bakker Lars‐Petter , Anyan Frederick 
Published: November 2023

AbstractUsing latent profile analyses, the current work investigated levels of adverse childhood experiences, symptoms of anxiety and depression and 3 dimensions of relational promotive factors) to identify resilience profiles in a large general population sample (N = 161,622, mean age = 53.02; SD = 17.80; 56.1% females). We then used the same method to identify the resilience profiles of military veterans (N = 386, mean age = 43.47; SD = 10.08; 9.8% females), all of whom had served in Afghanistan. A four‐profile‐solution was the best fitting for the general population (High resilient 30%, Moderate resilient 13%, Low resilient 53%, Work/social‐based resilience 4%), while a three‐profile‐solution had the best fit in the veteran cohort (Family‐based resilience 28%, Work/social‐based resilience 62%, Hardy loners 10%). To ground the identified profiles in occupational function, we also checked how they predicted reports of sleep difficulties, job demand and job control. Despite both samples inhabiting a geographic region known for high socioeconomic similarity among residents, we found marked differences in profile‐solutions between the military veterans and the general population. Our findings suggests that resilience profiles are highly influenced by cohort characteristics and the specific resources needed to manage a given stressor load. Accordingly, the generalisability of specific protective factors may be low across distinct cohorts, and reliable findings need to be obtained in specific populations as defined by stressor context, sample characteristics, and relevant outcomes.
“Things your history teacher won't teach you: Science edition”: Black women science teachers as anti‐racist teachers
Authors: Riley Alexis D. , Mensah Felicia Moore 
Published: November 2023

AbstractMarginalized communities cannot and do not have decontextualized experiences with how socioscientific issues, such as exposure to COVID‐19 as frontline essential workers, high Black infant mortality rates, air pollution leading to respiratory problems, and other issues, affect their communities. As PreK‐12 science teachers and teacher educators strive to dismantle oppressive practices in their classrooms and curriculum, it would be helpful to learn from Black women science teachers who have been engaging in anti‐racist practices before the racial awakenings of Summer 2020. In this study, three different virtual focus groups, or Sista Circles, were conducted with 18 Black women secondary science teachers. Ranging from 1 to 22 years of experience, Black women teachers across the country and international participants in Canada and Qatar participated in the Sista Circles. From intersectional qualitative analysis and narrative inquiry, the findings of the study reveal that Black women science teachers enact anti‐racist science teaching by bringing something new to the community; using NGSS standards within the context of the community; teaching at the intersection of history, culture, and science learning and teaching; and building critical consciousness in the science classroom. Furthermore, the findings of the study have implications for the use of anti‐racist frameworks within the context of science education that were authentically the practices of the Black women in the study. This study offers insights into how the critical consciousness of Black women teachers can be represented in the science classroom even in times of nonsupport from peers and administration. The power and necessity of Black women teachers are paramount in science classrooms specifically because of the neutral, apolitical ways science teaching has been approached in the past. The narratives and stories shared here exemplify how Black women science teachers transform science teaching and learning by displaying various acts of Criticality.
A Book Proof of the Middle Levels Theorem
Authors: Mütze Torsten 
Published: November 2023

AbstractWe give a short constructive proof for the existence of a Hamilton cycle in the subgraph of the $$(2n+1)$$

(
2
n
+
1
)

-dimensional hypercube induced by all vertices with exactly n or $$n+1$$

n
+
1

many 1s.