bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PENGARUH BRAND AMBASSADOR BLACKPINK TERHADAP MINAT BELI PRODUK OREO
Authors: Malihah Lola , Meilania Gusti Tasya 
Published: December 2023

Each company carries out various strategies to market its products, including companies that produce food and beverages. One of the trending food products is wafers of various types. In order to attract consumers, the company uses the services of a brand ambassador who plays a role in helping the smooth marketing activities of the products offered. Promotion using brand ambassadors is considered to be able to attract the attention of consumers. This study aims to determine the influence of Blackpink brand ambassadors on the interest in buying Oreo products. There are two variables in this study, namely the Brand Ambassador variable (X) and the Product Buying Interest variable (Y). This study used a quantitative approach by involving 36 respondents, namely santriwati Pondok Pesantren Salafiyah Darussalam Martapura as samples collected using purposive sampling techniques, where the criteria were students who had purchased Oreo Balckpink products. The analysis methods used are validity, reliability, classical assumption tests and simple linear regression analysis. In this study, the results were obtained that the Black Pink brand ambassador had a significant and positive influence on the interest in buying Oreo products. With the value R = 0.914., so it can be said that the relationship of independent and dependent variables in this study is very strong. This shows that the ambassador brand has a big role in increasing buying interest so that sales volume will also increase.Setiap perusahaan melakukan berbagai strategi untuk memasarkan produk-produknya, termasuk perusahaan yang memproduksi makanan dan minuman. Salah satu produk makanan yang menjadi tren yaitu wafer dengan berbagai jenis. Agar menarik minat konsumen perusahaan menggunakan jasa brand ambassador yang berperan dalam membantu kelancaran aktivitas pemasaran produk yang ditawarkan. Promosi dengan menggunakan brand ambassador dianggap mampu menarik perhatian konsumen. Penelitian ini bertujuan untuk mengetahui pengaruh brand ambassador Blackpink terhadap minat beli produk Oreo. Terdapat dua variabel dalam penelitian ini yaitu variabel Brand Ambassador (X) dan variabel Minat Beli Produk (Y). Penelitian ini menggunakan pendekatan kuantitatif dengan melibatkan 36 responden yaitu santriwati Pondok Pesantren Salafiyah Darussalam Martapura sebagai sampel yang dikumpulkan dengan teknik purposive sampling, dimana yang menjadi kriteria adalah santriwati yang telah membeli produk Oreo Balckpink.. Metode analisis yang digunakan berupa uji validitias, reliabilitas, uji asumsi klasik dan analisis regresi linear sederhana. Pada penelitian ini diperoleh hasil bahwa brand ambassador Black Pink memiliki pengaruh yang signifikan dan positif terhadap minat beli produk Oreo. Dengan nilai R = 0,914., sehingga dapat dikatakan bahwa hubungan variabel independen dan dependen dalam penelitian ini sangat kuat. Hal ini menunjukkan bahwa brand ambassador memilki peran besar dalam meningkatkan minat beli sehingga volume penjualan juga akan meningkat.
Bazı Çilek Çeşitlerinde Bor ve Bal Arısı Uygulamalarının Tozlanma Başarısı Üzerine Etkileri
Authors: KARABIYIK Şenay , SARİDAS Mehmet Ali , PAYDAŞ Sevgi 
Published: December 2023

Bu çalışmada, bal arılarının olduğu ve olmadığı yetiştirme ortamları ile B gübresinin farklı şekillerde uygulanmasının Fortuna ve Rubygem çilek çeşitlerinde tozlanma başarısı üzerine etkileri incelenmiştir. Çalışma İspanyol tipi yüksek tüneller altında yürütülmüştür. Tünellerin birinde tozlayıcı olarak arı faaliyetine izin verilmesine karşın, diğer tünel monofilament beyaz renkli dokuma tülü ile tünel plastiği üzerinden tamamen kapatılarak arı faaliyetine izin verilmemiştir. Topraktan, yapraktan ve toprak+yapraktan yapılan bor uygulamaları kontrol bitkileri ile yetiştirme sezonu boyunca tozlanma başarısı bakımından karşılaştırılmıştır.
Çalışma sonucunda tozlanma başarısının arı faaliyetiyle ilişkili olduğu, fakat çeşide göre farklı B uygulamaları ile arttırılabileceği, incelenen dönem içerisindeki iklimsel faktörlerin ise tozlanma başarısı üzerine etkisinin önemsiz olduğu belirlenmiştir.
Pengaruh Pengumuman Akuisisi terhadap Abnormal Return Saham (pada Perusahaan yang Terdaftar di BEI Tahun 2019)
Authors: Hakika Elka , Pertiwi Dwi Ari 
Published: December 2023

Penelitian ini bertujuan untuk menguji perbedaan Abnormal return saham sebelum dan sesudah pengumuman akuisisi pada perusahaan yang terdaftar di Bursa Efek Indonesia tahun 2019. Metode yang digunakan dalam penelitian ini yaitu kuantitatif dengan jenis penelitian komperatif (membandingkan). Populasi dalam penelitian ini adalah perusahaan yang menyajikan laporan keuangan di BEI tahun 2019. Teknik pengambilan sampel menggunakan metode porpusive sampling, sehingga didapatkan sampel sebanyak 35 perusahaan yang melakukan akuisisi tahun 2019. Teknik analisis data yang digunakan penelitian ini adalah uji T Parsial dengan hasil penelitian nilai sig sebesar 0,000 < 0,005, yang artinya menunjukkan bahwa terdapat pengaruh yang signifikan sebelum dan sesudah pengumuman akuisisi terhadap abnormal return saham. pengujian R Square sebesar 0,951 sehingga nilai akuisisi dapat menjelaskan abnormal return sebanyak 95,1% dan sisanya senilai 4,9% disebabkan variabel yang tidak terdapat pada penelitian ini
Analisis Perbandingan Perhitungan Penyusutan Aktiva Tetap pada PT. Industri Jamu dan Farmasi Sido Muncul, Tbk
Authors: Rohmatin Waalfa Maegadur , Ardiana Meta 
Published: December 2023

Perusahaan tentunya mengharapkan laba yang maksimal atas usahanya. Pencapaian laba secara maksimal sangat dipengaruhi oleh kegiatan operasional perusahan yang didukung dengan adanya peralatan, mesin, bangunan yang disebut dengan aktiva tetap. Penelitian ini bertujuan untuk mengetahui perbandingan penerapan perhitungan metode penyusutan aktiva tetap menurut Standar Akuntansi Keuangan (SAK), dan Undang-Undang Perpajakan pada PT. Industri Jamu dan Farmasi Sido Muncul, Tbk. Jenis metode penelitian ini adalah penelitian kualitatif dengan pendekatan studi kasus. Informasi dalam metode kualitatif diperoleh dengan cara dokumentasi yang selanjutnya akan dideskripsikan sehingga akan memudahkan pembaca dalam memahami penelitian. Hasil penelitian menunjukkan bahwa perhitungan penyusutan aset tetap berdasarkan standar akuntansi keuangan (SAK) pada tahun 2019, menghasilkan beban penyusutan yang lebih rendah dibandingkan perhitungan penyusutan berdasarkan Undang-Undang Perpajakan yang mengakibatkan adanya koreksi fiskal negatif. Sedangkan pada tahun 2020-2021 menghasilkan beban penyusutan yang sesuai dengan SAK dan Undang-Undang Perpajakan
CAMPURAN ETHANOL – NILAI OKTAN 92 DAN KONDUKTIFITAS TERMAL BUSI TERHADAP DAYA DAN EMISI MOTOR 110 CC
Authors: Mohammad Firman Rachmansyah Mohammad Firman Rachmansyah 
Published: December 2023

Bahan bakar merupakan komponen utama dalam proses pembakaran di ruang bakar kendaraan. Untuk meminimalisir penggunaan bahan bakar fosil yang semakin meningkat, diperlukan bahan bakar alternatif pengganti minyak bumi. Bioetanol dapat digunakan sebagai bahan bakar alternatif pengganti minyak bumi.
Busi adalah komponen penting yang berfungsi sebagai proses pengapian didalam ruang bakar. Busi memberikan percikan bunga api yang nantinya akan memicu pembakaran di ruang bakar.
Penelitian ini bertujuan untuk mengetahui pengaruh percampuran bahan bakar bioethanol terhadap daya dan emisi gas buang dengan perbandingan konduktifitas termal busi standar dan iridium.
Metode penelitian ini menggunakan metode eksperimental serta analisis data.
Variabel bebas dalam penelitian adalah oktan 92,konduktifitas termal busi standar dan iridium. Variable kontrol putaran mesin mulai dari 3000 RPM, 4000 RPM, 5000 RPM, 6000 RPM dan Variabel terikat dalam penelitian ini adalah daya dan emisi gas buang.
Hasil penelitian ini menunjukkan penggunaan bioethanol sebesar 30% menghasilkan daya sebesar 7,93 hp pada Rpm 6000 menggunakan konduktifitas termal busi iridium dan menghasilkan emisi yang sangat baik juga.
JENIS PLASTIK DAN MINYAK PLASTIK PYROLYSIS-RON 90 TERHADAP DAYA DAN EMISI MOTOR 150 CC
Authors: Fath Agung Brigytta Fath Agung Brigytta 
Published: December 2023

Energi merupakan salah satu kebutuhan dalam kehidupan sehari-hari dimana kebutuhan utama energi masih tergantung pada bahan bakar fosil minyak bumi dan gas, Bahan bakar merupakan salah satu kebutuhan kedua yang terpenting setelah kebutuhan manusia akan pangan, sandang dan papan.
Tujuan dari penelitian ini untuk mengetahui daya dan emisi gas buang menggunakan minyak plastik jenis PP dan PE serta variasi campuran bahan bakar minyak hasil pirolisis limbah plastik dengan pertalite. Adapun variasi campuran bahan bakar yang digunakan terdiri dari 0% atau pertalite murni, 10% minyak hasil pirolisis limbah plastik 90% pertalite, 20% hasil pirolisis limbah plastik 80% pertalite, 30% hasil pirolisis limbah plastik 70% pertalite.
Metode yang digunakan adalah eksperimental dengan tujuan penelitan untuk mencari campuran terbaik antara pertalite dengan bahan bakar hasil pirolisis limbah plastik.
Hasil pengujian ini menunjukkan bahwa untuk daya tertinggi dan emisi terendah menggunakan bahan bakar hasil pirolisis limbah plastik jenis PP pada campuran 10% minyak plastik dan 90% ron 90 menghasilkan 9,49 hp dan emisi CO 0,48 % dan HC 68 ppm
Enhancing photoelectrochemical CO2 reduction with silicon photonic crystals
Authors: Zhou Chu , Zhang Gaotian , Guo Peiyuan , Ye Chenxi , Chen Zhenjun , Ma Ziyi , Zhang Menglong , Li Jingbo 
Published: December 2023

The effectiveness of silicon (Si) and silicon-based materials in catalyzing photoelectrochemistry (PEC) CO2 reduction is limited by poor visible light absorption. In this study, we prepared two-dimensional (2D) silicon-based photonic crystals (SiPCs) with circular dielectric pillars arranged in a square array to amplify the absorption of light within the wavelength of approximately 450 nm. By investigating five sets of n + p SiPCs with varying dielectric pillar sizes and periodicity while maintaining consistent filling ratios, our findings showed improved photocurrent densities and a notable shift in product selectivity towards CH4 (around 25% Faradaic Efficiency). Additionally, we integrated platinum nanoparticles, which further enhanced the photocurrent without impacting the enhanced light absorption effect of SiPCs. These results not only validate the crucial role of SiPCs in enhancing light absorption and improving PEC performance but also suggest a promising approach towards efficient and selective PEC CO2 reduction.
The global burden of cardiovascular diseases and type 2 diabetes attributable to low physical activity, 1990–2019: an analysis from the global burden of disease study
Authors: Zhang Junhan , Yuan Zongxiang , Mo Chuye , Kang Yiwen , Wang Fengyi , Wei Xueqin , Huang Shihui , Qin Fang , Jiang Junjun , Liang Hao , Ye Li 
Published: December 2023

BackgroundCardiovascular diseases (CVD) and type 2 diabetes (T2D) account for the majority of the burden of noncommunicable disease caused by low physical activity (LPA). In order to inform future interventions, this study aims to assess the burden and trends in mortality and disability-adjusted life years (DALYs) of CVD and T2D attributable to LPA by year, location, sex, and age from 1990 to 2019.MethodsMortality, DALYs, and their age-standardised rates (ASMR, ASDR) for CVD and T2D attributable to LPA were retrieved from Global Burden of Disease (GBD) 2019. The estimated annual percentage changes (EAPCs) were calculated using linear regression model to describe the trend over time.ResultsFrom 1990 to 2019, the number of deaths caused by both CVD and T2D due to LPA increased significantly globally. However, the overall ASMR and ASDR for CVD declined over this same period [EAPC for ASMR (CVD) = −1.44 (95% CI: −1.50–1.38), EAPC for ASDR (CVD) = −1.30 (95% CI: −1.35 to −1.25)]. In terms of disparities, ASMR (CVD) and ASDR (CVD) in North Africa and the Middle East were consistently higher than the global average; also, the sex difference in ASMR was greatest in Central Asia. ASMR among people aged 25–44 in high Socio-Demographic Index (SDI) region has increased significantly over the past three decades. ASMR (T2D) due to LPA showed an increasing trend year by year, with EAPC = 0.26 (95% CI: 0.13–0.39), and this rate increased faster in males than in females. Consistent with cardiovascular diseases, ASMR of type 2 diabetes attributable to LPA increased among people aged 25–44, while decreased in other age groups in high SDI region.ConclusionInterventions targeting LPA are warranted in controlling the burden of cardiovascular diseases and type 2 diabetes. Countries should adapt strategies to their local contexts, considering the sex and age differences among their populations. The 25–44 age group should be given special attention to prevent the disease burden from worsening among younger people.
Circulating microRNAs as biomarkers of Chagas cardiomyopathy
Authors: Antonietti Laura , Mariani Javier , Martínez María Jose , Santalla Manuela , Vensentini Natalia , Kyle Diego Alfredo , de Abreu Maximiliano , Tajer Carlos , Lacunza Ezequiel , Ferrero Paola 
Published: December 2023

BackgroundChagas cardiomyopathy (CHCM) is the most important clinical manifestation of Chagas disease. The analysis of cardiac miRNAs may contribute to predicting the progression to CHCM in Chagas indeterminate phase and/or to the differential diagnosis for cardiomyopathy.MethodsWe carried out a case-control study to identify circulating miRNAs associated with CHCM. We assigned 104 participants to four groups: healthy controls (HC), Chagas non-cardiomyopathy controls, CHCM cases, and ischemic cardiomyopathy controls. We performed a clinical, echocardiographic, and laboratory evaluation and profiled circulating miRNA in the serum samples.ResultsDifferences between groups were observed in clinical variables and in the analysis of miRNAs. Compared to HC, CHCM participants had 4 over-expressed and 6 under-expressed miRNAs; miR-95-3p and miR-130b-3p were upregulated in CHCM compared with controls, Chagas non-cardiomyopathy and ischemic cardiomyopathy participants, suggesting that might be a hallmark of CHCM. Analysis of gene targets associated with cardiac injury yielded results of genes involved in arrhythmia generation, cardiomegaly, and hypertrophy.ConclusionsOur data suggest that the expression of circulating miRNAs identified by deep sequencing in CHCM could be associated with different cardiac phenotypes in CHCM subjects, compared with Chagas non-CHCM, ischemic cardiomyopathy controls, and healthy controls.
Pedagogical interventions and their influences on university-level students learning pharmacology-a realist review
Authors: Khurshid Faraz , O’Connor Elizabeth , Thompson Rachel , Hegazi Iman 
Published: December 2023

IntroductionThe knowledge complexity and varied delivery formats in pharmacology education can leave students unprepared in essential pharmacotherapy skills. This significantly influences their ways of thinking and working in clinical environments, resulting in a challenging clinical transition. This need demands pedagogical innovations to strengthen pharmacology education and improve learners’ skills and competencies in pharmacotherapy. This evidence-based realist review aimed to examine the contextual factors and program theories or causal mechanisms crucial for effective pedagogical interventions in pharmacology, seeking to answer the question of ‘what works for whom, under what circumstances, how, and why’.MethodThe realist synthesis was initiated after retrieving data from Medline (OVID), Cochrane, EBSCO hosted ERIC, SCOPUS, and Embase (OVID) including other sources for additional records. The preliminary analysis enabled the establishment of context, mechanism, and outcome configurations (CMOC) and formulation and refinement of the initial program theory regarding the pedagogical interventions in pharmacology. Data synthesis iteration helped to identify the relevant context and unravel its relationships with underlying causal mechanisms through which said interventions generate outcomes of interest.ResultsA realist review analyzed 1,217 records and identified 75 articles examining a range of educational interventions from individual efforts to faculty-wide curriculum changes in pharmacology education. The key contexts for pharmacology education were troublesome content, traditional delivery methods, inadequate and limited opportunities for knowledge integration, and application. Active participation in interactive learning, along with enjoyment and motivation, was proposed as a causal mechanism for optimizing cognitive load and achieving positive outcomes. The outcomes of the review include subjective perceptions of improved confidence and satisfaction, objective measurements of high post-test scores.DiscussionPedagogical scaffolding in constructivist learning environments helps students overcome challenges in learning troublesome pharmacology knowledge. Considering the human cognitive system’s processing capacity, these interventions improve learning by effectively using cognitive resources. Innovations that focus on enhancing cognitive load through task construction can also promote positive emotional experiences in students, such as engagement and enjoyment, as explained by flow theory. A constructive learning environment, where the cognitive load is optimized and high flow is achieved, can maximize the impact of pedagogical interventions in pharmacology.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=160441, PROSPERO (CRD42020160441).
Writing experiences of neurodiverse students in graduate STEM programs
Authors: Syharat Connie Mosher , Hain Alexandra , Zaghi Arash E. , Deans Thomas 
Published: December 2023

BackgroundDespite efforts to increase the participation of marginalized students, neurodivergent students remain underrepresented in graduate STEM programs. Prior research shows that these students often experience challenges related to key aspects of writing. The objective of this qualitative study is to deepen understanding of the writing experiences, strengths, and challenges of neurodivergent students pursuing graduate degrees in STEM fields. In this analysis, we consider the factors that influence the writing-specific challenges faced by neurodivergent students in graduate STEM programs. This work also explores how neurodivergent students leverage strengths and strategies for success in graduate-level writing tasks.ResultsThis qualitative study draws on Social Cognitive Theory (SCT) to consider the ways cognitive, behavioral, and environmental factors impact writing experiences. We used thematic analysis of the transcripts from 13 focus groups and 1 interview to examine the writing experiences of 31 students who identify as neurodivergent in graduate STEM programs. The findings suggest that many writing challenges faced by neurodivergent graduate students are behaviors and beliefs that emerge in response to environmental factors such as the culture of STEM fields, prior experiences with writing assignments, anxiety driven by intensive feedback cycles, and perceived and experienced stigma. Study participants employed a range of collaborative and situational strategies to support and enhance their writing productivity.ConclusionThese findings may provide insight for current and future neurodivergent graduate students as they adjust to the intense writing demands of graduate degree programs and for graduate program administrators and faculty advisors as they consider new ways to support the academic success of neurodivergent graduate students.
Functional and structural analysis of a novel splice site HMBS variant in a Chinese AIP patient
Authors: Wang Xiaoqing , Zhang Huifen , Huang Huanhuan , Wang Wenli , Wen Yuping , Dai Zhuojin , Huang Shuling , Zhou Jingyi , Zhou Yuqing 
Published: December 2023

Background: Acute intermittent porphyria (AIP) is a rare metabolic disorder that results from mutations in the gene encoding hydroxymethylbilane synthase (HMBS), an enzyme involved in heme biosynthesis. AIP follows an autosomal dominant inheritance pattern, but most carriers are asymptomatic. The clinical manifestations of AIP include acute attacks of abdominal pain and neuropsychiatric disturbances. The pathogenicity of novel HMBS variants identified in Chinese patients has not been well established.Objective: The article aims to identify the pathogenic mutation in an AIP patient and prove its pathogenicity through in vitro experiments.Methods: A 22-year-old female diagnosed with AIP participated in the study. Variant screening of her HMBS gene was carried out through Sanger sequencing. To ascertain the consequences of the newly discovered variant, we conducted in vitro experimentation targeting HMBS gene expression and enzymatic function. Additionally, protein structure analysis was performed. Cycloheximide treatment and UPF1-specific siRNA knockdown were employed to assess the impact of the mutation on the mechanism of non-sense-mediated mRNA decay (NMD).Results: A novel splice site variant in the HMBS gene (c.648_651+1delCCAGG) was detected in the patient, which caused aberrant mRNA splicing. In vitro experiments demonstrated that this variant significantly decreased the expression of HMBS. Further investigation confirmed that this decrease was due to NMD. Additionally, structural analysis indicated that this variant would destabilize the HMBS protein and impair its catalytic activity. To gain a comprehensive understanding of HMBS mutations in the context of AIP, we conducted a literature search on PubMed using the keywords ‘HMBS’ and ‘Acute intermittent porphyria’ from 2013 to 2023. This search yielded 19 clinical case reports written in English, which collectively described 220 HMBS gene mutations worldwide.Conclusion: The study identified and proved the pathogenicity of a novel splice site HMBS variant for the first time. Our results elucidated the pathological mechanism by which this mutation causes AIP through reducing HMBS expression and activity. These findings provide theoretical guidance for the diagnosis, treatment and genetic counseling of AIP patients.
Food allergy spectrum in the tropic: clinical and epidemiological profiles in a colombian hospital. A cross-sectional study
Authors: Olaya-Hernandez Manuela , Vasquez Laura Del Mar , Silva Diana Lucia , Martinez-Betancur Sofia , Guerra Maria , Arias Oriana , Ramirez Luis Fernando , Serrano Carlos Daniel 
Published: December 2023

IntroductionFood allergy affects 2-10% of the general population; it is more frequent among children than among adults, and it is one of the leading causes of anaphylaxis. Diagnosis of food allergy requires a detailed medical history, skin tests, specific immunoglobulin E (IgE) tests for the food involved, and an oral challenge as final confirmation.ObjectivesThis study aimed to describe the clinical and epidemiological characteristics of patients who underwent oral food challenges for suspected food allergies in a reference center in Colombia.MethodologyAn observational, descriptive, cross-sectional and retrospective study was conducted. Data were retrospectively collected from patients who were evaluated in the allergology service and suspected of food allergy from 2011 to 2018. Quantitative variables are presented as means or medians depending on the normality of the distribution (assessed by the Shapiro-Wilk test), and categorical variables are presented as frequencies and percentages.ResultsA total of 215 controlled open challenges were performed on 176 patients, most of whom were children (69%). Thirty-one patients (17%) required another oral challenge with a second food, and 11 (6.25%) required another oral challenge with three foods. Twelve oral challenges (5.58%) were positive. Of these, five challenges were positive for cow’s milk, 5 were positive for shrimp, and 2 were positive for legumes (peanuts and lentils).ConclusionThe frequency of confirmed food allergies and the profile of food allergies in our population differs from that reported in other parts of the world.