bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure)
Authors: Gordon Morris , de Geus Anna , Banasiuk Marcin , Benninga Marc A , Borrelli Osvaldo , Boruta Mary , Darbari Anil , Dore-Stites Dawn , Gould Michelle , Hawa Juliette , Jones Kirsten Brooke , Khlevner Julie , Kilgore Alexandra , Mousa Hayat , Nurko Samuel , Sinopoulou Vassiliki , Tabbers Merit , Thapar Nikhil 
Published: February 2025

IntroductionFunctional constipation is common in childhood, with chronicity leading to a significant impact on patients and their families. There is a significant range of therapies available to healthcare professionals for this condition, with many novel or recently studied. There is a need for an update to the joint European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines last released in 2014. We present the prospectively agreed operating procedure and technical review protocol in this manuscript.Methods‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) will be used for all phases of this guideline development. The Guideline Development Group is formed by paediatric gastroenterologists from both the ESPGHAN as well as the NASPGHAN. A prospective exercise will agree on key outcomes, thresholds of magnitude that are significant at small, moderate and large levels. Systematic evidence searches, selection, extraction, appraisal and analysis will be performed following Cochrane guidance and GRADE guidance for objectively agreeing the certainty of findings. Additional use of network meta-analysis will identify areas of broad triangulation in the evidence. Summary of findings tables will be produced and inform evidence to decision frameworks. These will guide GRADE recommendations with voting to reach a consensus.
Neurodevelopmental delay, musculoskeletal disorders and dysmorphia associated with a novel pathogenic interstitial deletion of chromosome 10q21.1q21.3
Authors: Dutta Dibyendu , Black Jennifer , Montoya Emily A , Burrow Thomas Andrew , Shieh Joseph , McGivern Bobbi , Raymond Michelle , Sheedy Christina B , Smith Scott C. , Garg Ria 
Published: February 2025

BackgroundPrevious reports of distal deletions in chromosome 10q in patients have described distinct facial features combined with other neurodevelopmental abnormalities, including intellectual disability. However, the association of interstitial deletions in chromosome 10q with global developmental delay, musculoskeletal abnormalities, and dysmorphic features has not been previously reported.MethodsGenetic testing using whole exome sequencing (WES) was performed on three patients with neurodevelopmental delay, musculoskeletal abnormalities and dysmorphic features. Sequencing reads were aligned to the human genome build GRCh37/UCSC hg19 and analysed for both sequence and copy number variants.ResultsWES identified similar interstitial deletions in the 10q21.1q21.3 locus in all three patients. The deleted region includes online Mendelian inheritance in man (OMIM)-annotated genes with clinical significance, such asANK3(*600465),JMJD1C(*604503),EGR2(*129010),BICC1(*614295),ZNF365(*607818) andTFAM(*600438). Deletion of this region is considered pathogenic and is implicated in the aetiology of the clinical phenotypes observed in these patients.ConclusionsThis is the first report associating interstitial deletions in the 10q21.1q21.3 locus with neurodevelopmental delay, musculoskeletal abnormalities and dysmorphic features. Our findings highlight the clinical significance of this deleted region and suggest possible mechanisms underlying the observed pathological phenotypes.
The Newman Model for Phase-Change Electrodes: Physics-Based Hysteresis
Authors: Foster Jamie M. , Grudeva Yoana , Korotkin Ivan , Dickinson Edmund J.F. , Offer Gregory J , Richardson Giles 
Published: February 2025

Abstract
Many modern, commercially relevant Li-ion batteries use insertion materials that exhibit lithiation-induced phase change (e.g. lithium iron phosphate). However, the standard physics-based model---the Newman model---uses a microscopic description of particle lithiation (based on diffusion) that is incapable of describing phase-change behaviour and the physical origins of the voltage hysteresis exhibited by such phase-change electrodes. In this work a simple and rational model of hysteretic lithiation (in an electrode comprised of an ensemble of phase-change nanoparticles) is derived using an approach based on minimisation of the Gibbs energy. Voltage hysteresis arises naturally as a prediction of the model. Initially, equations that model the phase-change dynamics in a single particle of active material are considered. These are generalised to a model, termed the composite phase-change model, of a coupled ensemble of particles in a thin electrode. The composite phase-change model is then incorporated into the framework of a classical Newman model, allowing for the inclusion of transport effects in the electrolyte and electrode conductivity. The resulting modified Newman model is used to predict voltage hysteresis in a graphite/LFP cell. A simulation tool that allows readers to replicate, and extend, the results presented here is provided via the DandeLiion simulator at www.dandeliion.com.
Robust Difference and Ratio Type Estimators in Presence of  Correlated Measurement Errors  Under Ranked Set Sampling
Authors: Bhushan Shashi , Kumar Anoop 
Published: February 2025

In survey sampling, the problem of correlated measurement errors (CMEs) was initially addressed using conventional estimators under simple random sampling (SRS) and ranked set sampling (RSS). To evaluate the impacts of CMEs, this study proposes some robust difference and ratio types of estimators using RSS methodology. The statistical properties like bias and mean square error are derived up to a first-order approximation. An extensive simulation study is performed, and the results are obtained, which exhibit the robustness of the proposed estimators compared to their conventional counterparts. AMS 2000: MSC2020:62D05
Intravenous amino acids for kidney protection in patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials
Authors: Khan Malik Waleed Zeb , Ali Aizaz , Hussain Amna , Mian Aban Masaud , Moeez Abdul , Inayat Waqas , Noor Bushra , Shah Izhar Ali , Osama Muhammad , Khan Bushra , Sajid Muhammad , Azeem Touba , Ebad Ur Rehman Mohammad , Ali Ashraf , Afridi Ubaid Khan 
Published: February 2025

Objective To evaluate the efficacy of intravenous (IV) amino acids in preventing acute kidney injury (AKI) in patients undergoing cardiac surgery. Methods PubMed, EMBASE, and Cochrane Library databases were systematically searched for all relevant randomised controlled trials (RCTs) published from inception to July 25, 2024. A random effects model was used to pool the risk ratios (RR) for dichotomous outcomes, and the combined data was visually represented using forest plots. Results 3 studies involving 3646 patients were included in the meta-analysis. IV amino acids did not significantly lower the overall AKI incidence compared with control measures. However, they significantly reduced the risk of Stage 1 AKI and Stage 3 AKI. No differences were observed between intervention and control for Stage 2 AKI or need for kidney replacement therapy. Conclusion IV amino acids may offer protective benefits against severe AKI stages in cardiac surgery patients. Further studies are warranted to validate our findings.
Solving the paradox of Lean Management’s low success rate
Authors: Samson Danny , Ho William , Seyedghorban Zahra , Bevington Diana , Kelly Sally 
Published: February 2025

This study investigates problems related to the high variance in the success rate of lean implementations, using a unique data set from a specific approach to implementing lean. We develop insights about how to effectively resolve the ‘Lean paradox’, namely that Lean concepts promise so much in theory yet deliver infrequently in practice. Our primary data of 268 Lean implementation initiatives illuminates the core elements of lean implementation success that explain this success variance. We present an in-depth case study of that specific method of lean implementation. Lean implementation success occurs when specific processes are followed, namely integration of job role and process analysis, comprehensive end-to-end deployment rather than spot-based problem solving, use of operator-based data about processes and waste, detailed level of data and change deployment focussed on waste reduction, and ongoing measurement and control of process changes. These ‘how’ factors provide both conceptual and practical insights for managers. JEL Classification: M11
Indications for Lateral Extra-articular Tenodesis in Anterior Cruciate Ligament Reconstruction: A Systematic Review
Authors: Zabrzyński Jan , Kwapisz Adam , Erdmann Jakub , Zabrzyńska Maria , Błachowski Michał , Ohla Jakub , Adamczyk Michalina , Sokołowski Maciej , Majchrzak Bartosz , Huri Gazi 
Published: February 2025

Background: The anterior cruciate ligament (ACL) is a major sagittal plane stabilizer of the knee joint. Even if anterior laxity can be brought under control by utilizing modern surgical techniques, internal rotational instability may not always be controlled adequately. Various surgical techniques are used to prevent this coronal or rotational instability, such as lateral extra-articular tenodesis (LET). Despite an abundance of articles in recent decades discussing LET in ACL reconstruction, no definitive indicators for extra-articular tenodesis have been described in the literature. Purpose: Given the scarcity of literature assessing the indications in LET, the purpose of this study was to conduct a systematic review of the described indications for this operation in the context of concurrent ACL reconstruction. Study Design: Systematic review; Level of evidence, 4. Methods: We searched PubMed, Cochrane Central, ScienceDirect, Web of Science, and Embase using the following key terms with no limits regarding the year of publication: (extraarticular OR extraarticular) AND (tenodesis OR plasty OR augmentation OR procedure or reconstruction OR reconstructive OR surgical OR surgery OR technique) AND (ACL OR anterior cruciate ligament). We included clinical human studies based on levels of evidence 1 to 4 that were written in English. We excluded studies not written in English, case studies, reviews, letters to editors, conference abstracts, or studies containing incomplete or irrelevant data. Results: The analysis evaluated 29 articles published between 1999 and 2023. We evaluated mostly level 3 (n = 13) and level 4 (n = 12) evidence; however, there were 4 articles with level 1 evidence. The majority of the studies were retrospective (n = 21), although there were prospective studies (n = 8). The mean age of the participants was 24.4 years. The most prevalent indications for LET were high-risk sports (16 articles), medial meniscal repair/excision (11 articles), and pivot-shift test grades 2 and 3 (11 articles). Conclusion: The reviewed articles showed reduced pivoting and laxity, improved clinical outcomes, and decreased revision rates after primary ACL reconstruction. The main frequent and repeated indications for using LET in ACL reconstruction are meniscal surgery, sports activity, and grade 2 and 3 pivoting.
Early Check-In Protocol: Identifying Medication Issues in Patients with Cancer at Health System Specialty Pharmacy
Authors: Phillips Kayla Ann , Wash Andrew , Hutchinson Kristin , Cash Katie Jo , Giavatto Carly , Fitzpatrick Casey , Hunter Abbey , Page Olivia , Mourani Jessica , Lopez-Medina Ana I 
Published: February 2025

Introduction Several studies have illustrated value in early patient contact following oral anticancer medication (OAM) initiation, particularly within the first 14 days of therapy, as adverse effects may lead to early discontinuation or poor adherence. Health-system specialty pharmacies (HSSPs) are optimally positioned to adopt this best practice through formalized protocols designed to identify and mitigate medication-related issues. Objective To outline an HSSP-led early check-in protocol for patients taking OAMs and to describe the subsequent interventions conducted by the HSSP team and their acceptance rate. Results HSSPs enacted a protocol in January 2021 requiring oncology pharmacists - to contact patients within 14 days of OAM initiation, aiming to optimize adverse effect management, offer supportive care, address adherence, and provide education. To evaluate the impact of the early check-in protocol, we conducted a retrospective, multicenter, observational study across CPS’s health system clients from January 2022 to November 2023. HSSP pharmacists created 1698 interventions for 1184 patients from the early check-in. The cancer types most frequently associated with an intervention were breast (n = 431, 25.4%), gastrointestinal (n = 245, 14.4%), and prostate (n = 206, 12.1%). The most frequent intervention categories were adverse drug reactions (ADRs) (n = 1,548, 91.2%) and adherence (n = 55, 3.2%). Overall, 95.5% of pharmacist recommendations were accepted by patients and/or providers. Conclusion Implementing an early check-in protocol allows HSSP pharmacists to mitigate barriers to OAM adherence. This study emphasizes the importance of early check-in and illustrates the scope of the oncology pharmacist’s role by evaluating critically meaningful interventions and quantifying pharmacist recommendations and acceptance rate.
A redundant steering-by-wire system and multi-axle cooperative steering control algorithm for super autonomous rapid transit
Authors: Liu Hongda , Yu Haizhou , Xie Chenghui , Yang Ying , Shen Longjiang , He Anqing 
Published: February 2025

In view of the safety problems of the single-channel hydraulic steering system which widely used in the multi-axle cooperative steering system of super autonomous rapid transit (SRT), a multi-axle cooperative steering system based on redundant steering-by-wire is developed. Firstly, the real-time task and system status judgment are placed in the master station of the steering controller for processing, fully ensuring the real-time performance of the task. At the same time, the slave station is set to synchronously process the task and judge the status. The two channels of the steering system work simultaneously, and when one channel fails, the other channel can take over the system in real time. This redundancy strategy ensures the safety of the vehicle. Secondly, a multi-axle cooperative steering control algorithm for SRT is proposed. The steering control system consists of a feedforward and an additional feedback control. The feedforward control is subdivided into three steps. In a first step the angle of axle 2 is calculated with dynamic model of first module and the driven path is estimated. This path is used in a second step to calculate the desired kinematics and finally the desired kinematics are transformed into the desired lateral forces by means of the inverse vehicle model. An additional nonlinear feedback controller stabilizes the tracking behavior on vehicle status level. By establishing the kinematics model of SRT and adopting the PID control of yaw angle deviation, the control error of the vehicle is dynamically compensated, and the control accuracy and robustness of the SRT multi-axle cooperative control algorithm are ensured. The steering system has been applied to the three-module & six-axle SRT, with the functions of steering-by-wire and track following, and can achieve the minimum turning radius of 15 m, and its good control accuracy and stability are verified by experiments.
Successful management of drug-resistant rhizobium radiobacter endophthalmitis: A case report
Authors: Wu Po-Ying , Wu Horng-Jiun 
Published: February 2025

Purpose To report a unique case of post-cataract surgery endophthalmitis caused by Ceftazidime-resistant Rhizobium radiobacter, successfully managed with timely vitrectomy and intravitreal Levofloxacin Case report A healthy 73-year-old man underwent phacoemulsification and posterior chamber intraocular lens implantation in his left eye. Postoperative ocular examination (OE) one day after the surgery revealed no specific findings. However, on postoperative day 6, he presented with a painful and red left eye. Diagnosed with postoperative endophthalmitis on day 8 at another hospital, he received IVI of Ceftazidime and Vancomycin before being urgently referred to our hospital on the same day. Early vitrectomy and anterior chamber irrigation were performed timely when he arrived on day 8, with cultures identifying Ceftazidime-resistant Rhizobium radiobacter, sensitive to Levofloxacin. Repeated IVI of Levofloxacin (500 mcg/0.1 ml) ensued on post-cataract operative days 13 and 18. Six months post-cataract surgery, the corrected distance visual acuity of the left eye stabilized at 20/33, and OE remained stable. Conclusion Early vitrectomy and vitreous culture prove effective in managing postoperative endophthalmitis in drug-resistant Rhizobium radiobacter. IVI of Levofloxacin, though rare, proved to be effective in treating Ceftazidime-resistant and Levofloxacin-sensitive pathogens in our case.
Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis
Authors: Bokemeyer Bernd , Serdani-Neuhaus Leonarda , Sünwoldt Juliane , Dünweber Christina , Schnaidt Svitlana , Schuppan Detlef 
Published: February 2025

Background: Coeliac disease (CeD) is a chronic immune-mediated disease triggered by exposure to dietary gluten in genetically predisposed individuals. The burden of CeD on patients and the healthcare system remains poorly evaluated in Germany. Objectives: To assess the healthcare resource utilisation (HCRU) and costs of diagnosed CeD patients in a German claims database. Design: A retrospective CeD case–control study was conducted using German claims data between 2017 and 2021. Methods: CeD diagnosis was defined by at least one inpatient or two outpatient diagnostic codes (International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification (ICD-10-GM) K90.0) within four quarters (irrespective of calendar year) for CeD during the study period. Controls (non-CeD patients) were matched in a ratio of 5:1 by age, Charlson Comorbidity Index, sex and region. HCRU (hospitalisations, outpatient visits, medication use, sick leaves) and healthcare costs (outpatient services, inpatient services, outpatient pharmaceuticals, sick leaves and aids and remedies) were compared between CeD patients and controls. Results: From the 3,352,188 patients with continuous enrolment during the study period (2017–2021), 8258 (0.25%) patients were identified as having a CeD diagnosis. The mean number of hospitalisations and outpatient visits within 5 years was 1.8- and 1.5-fold higher among matched CeD patients ( n = 8243) compared to their controls ( n = 41,215), resulting in an excess healthcare cost of €5251. Inpatient expenses were the main cost driver and accounted for 31.5% of total incremental costs. Conclusion: The current study showed that CeD patients have considerably higher HCRU and related costs compared to matched controls. Our findings suggest the need for improved treatment options for CeD patients in addition to a gluten-free diet.
Efficacy of alternate mucosa–submucosa clip closure in preventing postoperative adverse events for patients with gastric mucosal lesions after endoscopic submucosal dissection: a multicenter retrospective study
Authors: Chen Lu , Jiang Jingjing , Li Hongxia , Yin Xin , Tang Xiajiao , Zhu Yinnan , Chen Wei , Lu Qin , Shi Ruihua 
Published: February 2025

Background: Endoscopic submucosal dissection (ESD) is the first-line treatment for gastric mucosal lesions. The artificial ulcers caused by ESD can lead to bleeding, perforation, and other adverse events. Objectives: This study aimed to evaluate the efficacy of alternate mucosa–submucosa clip in preventing adverse events following ESD for gastric mucosal lesions. Design: Multicenter retrospective observational study. Methods: Data from 924 patients who underwent ESD for gastric mucosal lesions were retrospectively collected and categorized into completely closed and unclosed groups based on postoperative wound management. The incidence of adverse events and postoperative wound healing rate at 1 and 3 months were compared between the groups, and the factors related to delayed bleeding after ESD were analyzed. Results: The rate of delayed hemorrhage was lower in the completely closed group than in the unclosed group (0.8% vs 7.6%; p < 0.001), and subgroup analysis showed that this effect was consistent across all subgroups. The postoperative abdominal pain score was lower in the completely closed group than in the unclosed group (0 vs 2, p < 0.001). One month postoperatively, the wound healing rate was higher in the completely closed group (77.6% vs 55.1%; p < 0.001). Multivariable analysis showed that the presence of ulcers or scars on the lesion surface, and lesions located in the lower one-third of the stomach were risk factors for postoperative bleeding. Conclusion: Application of alternate mucosa–submucosa clip closing the wound of ESD reduced the risk of postoperative bleeding, alleviated postoperative abdominal pain, and promoted artificial wound healing.