bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use and Efficacy of Insulin Eye Drops in Neurotrophic Corneal Ulcers: A Systematic Literature Review
Authors: Amorim Ryan Jorge , Filho Jose Jesu Sisnando D'Araújo , Júnior Cantidio João Silva da trindade , Xavier Tássio Cruz , Nascimento Kelly Cristina Costa Guedes , Guimarães Glenda Figueira , Moraes Evelly Christinne da Silva , Sousa Daniele Salgado de , Alencar Patrick Souza de , Virgolino Rodrigo Rodrigues , Cardim Janaína Moraes , Lima Vitor Hugo Auzier 
Published: February 2024

This research aimed to analyse the use and efficacy of insulin eye drops in the treatment of neurotrophic corneal ulcers by means of a systematic literature review. To this end, relevant studies found in various databases were analysed, including PubMed, Scopus, Science Direct, Scielo, Bireme, Google Scholar and Web of Science. The selected studies were assessed in terms of their objectives, methodology, results and conclusions, with the aim of providing a comprehensive understanding of the current state of evidence on the subject. From the articles by Serrano-Giménez et al. [1], Wang et al. [2] Jaworski et al ([3], Tong et al. [4], Khilji et al. [5], Moreker et al. [6], Soares et al. [7], CUARTERO-MARTINEZ et al. [8], Lorente-Pascua et al. [9], Erin et al. [10], Diaz-Valle et al [11], Dana et al. [12] and Ruiz-Lozano et al. [13], trends, knowledge gaps and recommendations for clinical practice and future research were identified. As a result, the studies analysed showed a variety of outcomes in relation to the efficacy and safety of insulin eye drops in the treatment of neurotrophic corneal ulcers. There was also a lack of standardisation in the methods used and the evaluation measures, highlighting the need for a more uniform approach in subsequent studies. The main trends identified indicate that insulin eye drops can be effective in treating corneal neurotrophic ulcers, especially in refractory stages. However, there is a need for further research to define more precise diagnostic criteria and more standardised assessment measures. In conclusion, this systematic review has provided a solid basis for future research into the use of insulin eye drops in the treatment of corneal neurotrophic ulcers. The recommendations resulting from this study have the potential to inform clinical practice and guide future research in this field, with the aim of improving these procedures for patients with this specific ophthalmological condition.
In silico Toxicity and Pharmaceutical Properties to Get Candidates for Antitumor Drug
Authors: Adnyaswari Dewa Ayu Made , Indrayani Agung Wiwiek , Artini I. Gusti Ayu 
Published: February 2024

Background: Drug metabolism is a crucial aspect of medical practice and pharmacology, involving the transformation of drugs by various bodily systems to create compounds that are more easily eliminated from the body. Sorafenib was reported as a useful adjuvant treatment in patients with hepatocellular carcinoma who underwent surgical resection. However, poor pharmacokinetic properties such as limited water solubility, rapid elimination and metabolism lead to low bioavailability, restricting its further clinical application. Rosmarinic acid, soluble in ethanol and found in Rosemary leaves, has demonstrated therapeutic benefits in conditions such as cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver disease.
Method: In silico is a term for experiments or tests carried out using computer simulation methods. In silico testing has emerged as a valuable approach for initiating the exploration of novel drug compounds or enhancing the efficacy of existing ones. This method involves predicting, generating hypotheses, and uncovering potential breakthroughs in medicine and therapy through virtual simulations.
Results: Caco2 value of Sorafenib ligand as a comparison, namely 0.762. The highest Caco2 value is owned by Betulinic Acid and the value The lowest Caco2 is owned by Rosmarinic Acid. The highest sample HIA value was owned by Ursolic Acid and the lowest was owned by Rosmarinic Acid. Meanwhile, Sorafenib's HIA value is 85,494. ligands such as Carnosol and rosmanol have a high distribution volume, while the Sama carnosic league, ursolic acid and betulinic acid have a low distribution volume. The Rosmarinic acid ligand has a good distribution volume of 0.393, while the distribution volume value of Sorafenib is -0.009. The highest BBB sample value was owned by Carnosol and the lowest was owned by Rosmarinic acid. Meanwhile, the comparison ligand has a value of -1.473 and is considered less distributed in the brain. all ligands such as Carnosic Acid, Carnosol, Rosmanol, Ursolic Acid, Betulinic Acid, Rosmarinic acid do not have mutagenicity and Cytotoxic effects, but have an effect on immunity. The comparison ligand Sorafenib turned out to have effects on hepatotoxicity, immunity and cytotoxicity.
Conclusion: In pharmacokinetic research, the six phenolic acid compounds in Rosemary exhibited superior properties compared to the reference ligand Sorafenib.
Effects of vitamin D supplementation on mortality in critically ill patients: a systematic review and meta-analysis.
Authors: Lisboa Neide Barreto da Silva , Carvalho Jozélio Freire de 
Published: February 2024

Objective: This study aimed to use a meta-analysis to evaluate whether vitamin D supplementation can improve critically ill patients' parameters.Materials and Methods: A systematic review of the literature and meta-analysis was performed using the electronic databases PubMed, Cochrane, Medline, and Scielo. The selected studies are randomized controlled trials (RCTs) that evaluate the effect of vitamin D supplementation in critically ill patients over 18 years of age and are available in full. All of the articles involved randomized clinical trials that analyzed the effects of vitamin supplementation on mortality, length of ICU stay, length of hospital stay, and use of mechanical ventilation.
Results: The meta-analysis revealed that vitamin D supplementation in critically ill patients can reduce mortality in 28-30 days [RR =0.76 (95%CI: 0.57-1.00, p=0.05)] (p=0.85), hospital mortality (p=0.14), length of ICU stays (p=0.11), length of hospital stays (p=0.08) and time of mechanical ventilation (p=0.32).Conclusion: This meta-analysis demonstrated that vitamin D supplements in critically ill patients show a reduction in mortality in 28-30 days. Thus, it is suggested that critically ill patients who are 18 years of age or older should receive a dose of vitamin D greater than 150,000IU to obtain this benefit.
Marxismo, gênero, sexualidade e a luta anticapitalista: debates e controvérsias
Authors: Martins de Paula Helga Maria , Godoi Moraes Lívia de Cássia , Magalhães da Silva Márcio , Lemos Márcia , Quinalha Renan 
Published: February 2024

A proposta desse dossiê é divulgar pesquisas e colocar em discussão a luta de classes e as opressões no processo de superação do modo de produção capitalista. O ponto de partida são as reflexões balizadas pelo arcabouço teórico-metodológico do Materialismo Histórico e Dialético, que considerem exploração, subjetivação, alienação e consciência no exame das temáticas compreendidas como centrais para este debate: crise do capital e crise da reprodução social; gênero, raça, classe, sexualidades e crítica da economia política: leituras marxistas; neoliberalismo, privatização dos serviços essenciais e a classe trabalhadora racializada e LGBT; migração, mundialização neoliberal e o deslocamento de mulheres; Estado, direito e opressões de gênero; feminismo marxista, trabalho e organização sindical; análises em torno do trabalho doméstico e da maternidade privatizada; políticas sexuais e movimentos sociais; família como unidade de reprodução do capital, ascensão conservadora e pessoas LGBT's; a prostituição/trabalho sexual, a moral burguesa e a legalização; sexualidade e gênero na educação; Marxismo e teoria queer; feminismos marxista, socialista, materialista, transfeminismo, virada linguística e as lutas anticapitalistas.
Nitrilotriacetic Acid Functionalized Graft Copolymers: A Polymeric Interface for Selective and Reversible Binding of Histidine‐Tagged Proteins
Authors: Zhen G. , Falconnet D. , Kuennemann E. , Vörös J. , Spencer N. D. , Textor M. , Zürcher S. 
Published: September 2005

AbstractA series of novel graft copolymers, poly(L‐lysine)‐graft‐poly(ethylene glycol) (PLL‐g‐PEG) with 28, 46, and 96 % of the PEG chains carrying a terminal nitrilotriacetic acid (NTA) group, have been synthesized. Through electrostatic interactions, these polycationic graft copolymers assemble spontaneously from aqueous solution onto negatively charged surfaces, forming polymeric monolayers that present NTA groups at controlled surface densities. Such NTA‐presenting surfaces on a highly PEGylated background are attractive sensor platforms for the reversible binding, through Ni2+ ions, of histidine (His)‐tagged biomolecules such as proteins and antibodies. With these three polymers, NTA‐ligand surface densities of 16, 23, and 37 pmol cm–2, respectively, have been obtained. The surface assembly of the polymers, as well as their sensing performance, has been monitored quantitatively using in‐situ optical‐waveguide light‐mode spectroscopy. The NTA‐functionalized PLL‐g‐PEG surfaces prove to be highly resistant to non‐specific adsorption in contact with human serum, while allowing the specific and reversible surface binding of the 6 × His‐tagged green fluorescent protein (GFP)uv‐6His in its native conformation. The amount of GFPuv‐6His immobilized on the polymeric surface increases with increasing NTA surface density. Furthermore, micropatterns consisting of NTA‐functionalized PLL‐g‐PEG in a background of PLL‐g‐PEG are produced using the “molecular assembly patterning by lift‐off” technique. Exposure to Ni2+ and GFPuv‐6His results in a protein pattern of excellent contrast, as judged by fluorescence microscopy. The NTA‐functionalized PLL‐g‐PEG surface is considered to be a promising sensor platform for binding 6 × His‐tagged proteins, thanks to the simplicity and cost‐effectiveness of the surface modification protocol, the high specificity and nearly quantitative reversibility of the protein binding, and the potential for fabricating microarrays of multiple capture molecules.
Silicon Nanocrystals: Photosensitizers for Oxygen Molecules
Authors: Kovalev D. , Fujii M. 
Published: September 2005

AbstractMolecular oxygen plays an important role in many of the chemical reactions involved in the synthesis of biological life. In this review, we explore the interaction between O2 and silicon nanocrystals, which can be employed in the photosynthesis of singlet oxygen. We demonstrate that nanoscale Si has entirely new properties owing to morphological and quantum size effects, i.e., large accessible surface areas and excitons of variable energies and with well‐defined spin structures. These features result in new emerging functionality for nanoscale silicon: it is a very efficient spin‐flip activator of O2, and therefore, a chemically and biologically active material. This whole effect is based on energy transfer from long‐lived electronic excitations confined in Si nanocrystals to surrounding O2 via the exchange of single electrons of opposite spin, thus enabling the spin‐flip activation of O2. Further, we discuss the implications of these findings for physics, chemistry, biology, and medicine.
Road Map for the Controlled Synthesis of CdSe Nanowires, Nanobelts, and Nanosaws—A Step Towards Nanomanufacturing
Authors: Ma C. , Wang Z. L. 
Published: September 2005

AbstractOne‐dimensional (1D) nanostructures of CdSe have been found to exhibit morphologies of nanowires, nanobelts, and nanosaws, but their synthesis is by trial and error. To meet the needs of large‐scale, controlled, and designed synthesis of nanostructures, it is imperative to systematically find experimental conditions under which the desired nanostructures are synthesized reproducibly, in large quantity, and with controlled morphology. This article reports the first systematic study on the growth of 1D CdSe nanostructures by a vapor–liquid–solid (VLS) process by varying a wide range of experimental conditions. Over 150 experiments have been conducted to investigate the morphology dependence of three different types of nanostructures: nanowires, nanobelts, and nanosaws, over various substrate temperatures and pressures. The results of this work yield a road map for the controlled growth of 1D CdSe nanostructures. This research serves as a guidance and “menu” for scaling up of the synthesis of CdSe nanostructures. This is a key step towards the controlled synthesis of nanostructures to meet the needs of many industrial applications of nanomanufacturing.
Centrifugal drum filtration: I. A compression rheology model of cake formation
Authors: Barr John D. , White Lee R. 
Published: September 2005

AbstractA compression rheology model is used to describe the behavior of networking solids undergoing centrifugal filtration under batch operation. A description of the batch filtration process is accomplished through the use of the rheologic functions for compressive yield stress py(ϕ) and the hydrodynamic resistance R(ϕ), with a characteristic pressure scaling, timescaling, and membrane resistance. Comparison of the results of this model to those found in engineering text books indicates that noncompression models fail to describe the variation in the cake resistance. The compression rheology model also predicts that the effective cake resistance is approximately 20% larger than that predicted by conventional theory. © 2005 American Institute of Chemical Engineers AIChE J, 2006
Development of potentially biodegradable polyamide‐6 and polyvinyl alcohol blends: Physico‐mechanical properties, thermal properties, and soil test
Authors: Ramaraj B. , Poomalai P. 
Published: September 2005

AbstractBlends of polyamide‐6 with 5, 7.5, 10, 15, and 20 wt % of polyvinyl alcohol (PVA) were prepared by the extruding in a corotating twin‐screw extruder. The extrudate strands were cut into pellets and injection‐molded to make test specimens. These specimens were tested for physico‐mechanical properties such as tensile strength, impact strength, density, water absorption, hardness, and thermal characteristics by differential scanning calorimetry, heat distortion temperature (HDT), vicat softening point (VSP), and melt flow index. The prepared blends show enhanced biodegradation, water absorption, and density, but it is observed that the introduction of PVA into the polyamide–6 matrix shows considerable reduction in tensile strength, impact strength, HDT, VSP, and hardness initially, but subsequent addition does not show significant reduction because of the enhanced interaction between amide groups of polyamide‐6 and hydroxyl groups of PVA. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2339–2346, 2005
Flame‐retardant effect of polyaniline coating deposited on cellulose fibers
Authors: Stejskal Jaroslav , Trchová Miroslava , Sapurina Irina 
Published: September 2005

AbstractFiltration paper was coated with a thin polyaniline film. The content of conducting polymer was 8.2 and 6.3 wt % for polyaniline hydrochloride and polyaniline base, respectively. After burning, the coated material retains the original fibrilar morphology of cellulose. The polyaniline coating converts to solid carbonaceous products. The resulting structure prevents the formation of gaseous carbon oxides by restricting the access of oxygen to cellulose. While the ash from the uncoated paper after burning is 0.005 wt %, the microtubular residue of polyaniline‐coated paper is 16–24 wt % of the original mass. The flame‐retardant performance of polyaniline and poly(1,4‐phenylenediamine) coatings was comparable both for the protonated forms and the corresponding bases. The conversion of polyaniline‐coated cellulose fibers to solid pyrolytic products was characterized by FTIR and Raman spectroscopies. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2347–2354, 2005
Effect of processing conditions on the structure and properties of polypropylene spunbond fabrics
Authors: Nanjundappa Rammohan , Bhat Gajanan S. 
Published: September 2005

AbstractThe structure and properties of a spunbond fabric are determined by numerous process variables. The development of fiber morphology is influenced and controlled by extrusion and quenching conditions. The properties of the fabric are the result of the properties of the filaments, their arrangement in the web, and the bonding conditions. It is therefore critical to understand the relationship between the process conditions and the properties of the fabrics produced. This study was conducted to investigate the effects of some of the important process variables on the structure and properties of the filaments and ultimately on that of the fabrics. Process variables such as polymer throughput rate, cooling and suction air speed, web basis weight, and bonding temperature were investigated. Filament samples were collected before bonding and were analyzed for various properties such as crystallinity, crystallite size, birefringence, density, thermomechanical stability, and tensile properties. The fabric samples were analyzed for tensile properties, tear strength, stiffness, and crystallinity. Ruptured strips obtained from the tensile test were observed with a scanning electron microscope to understand the failure mechanism. The results were statistically analyzed to evaluate the effect of process variables on the properties and to predict the properties for different process conditions. The findings are helpful in determining the optimum processing conditions so as to achieve the desired properties. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2355–2364, 2005
Morphology and thermo‐mechanical properties of compatibilized polyimide‐silica nanocomposites
Authors: Al‐Kandary Sh. , Ali A. A. M. , Ahmad Z. 
Published: September 2005

AbstractPolyimide‐silica nanocomposites have been prepared from an aromatic polyamic acid derived from pyromellitic dianhydride and oxydianiline and a silica network using the sol‐gel reaction. Compatibilization of the two components was achieved by modifying the silica network with imide linkages. Morphology, thermal, and mechanical properties of these composite materials were studied as a function of silica content and compared with the one in which reinforcement of the polyimide was achieved using a pure silica network. There was considerable reduction in the silica particle size with more homogeneous distribution in the matrix when imide spacer groups were introduced in the silica network. The tan δ spectra obtained from dynamic thermal mechanical analysis shows a large increase in the glass transition temperature with increasing silica content for the compatibilized system in contrast to the un‐compatibilized one. Mechanical properties of the polyimide composites improved due to better interaction between the organic and inorganic phases. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2521–2531, 2005
Enhancement of radiation‐resistant effect in ethylene–vinyl acetate copolymers by the formation of ethylene–vinyl acetate copolymers/clay nanocomposites
Authors: Zhang Wei‐An , Fang Yue‐E 
Published: September 2005

AbstractEthylene–vinyl acetate (EVA) copolymers/clay nanocomposites, prepared by using nonreactive organophilic clay and reactive organophilic clay, were characterized by X‐ray diffraction and by high‐resolution transmission electron microscopy. The influence of gamma irradiation on the structure and properties of the pure EVA and EVA/clay nanocomposites was systematically investigated. In the presence of gamma radiation, the clay can effectively restrain the increase of the storage modulus of EVA/clay nanocomposites, which was supported by dynamical mechanical analysis. Gamma irradiation had almost no effect on the thermal properties of EVA/clay nanocomposites by using nonreactive organophilic clay, but it obviously improved the thermal stability of EVA/clay nanocomposites by using reactive organophilic clay. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2532–2538, 2005
Study on surface fluorinating for reducing attenuation of polymethyl methacrylate polymer optic fiber
Authors: Jiu‐Rong Chu , Li‐Sheng Zhong , Xu‐Ming Wen , Chuan‐Xiang Xu 
Published: September 2005

AbstractThe effects of surface fluorinating on the F/C ratio of polymethyl methacrylate (PMMA) are investigated. The F/C ratio of PMMA increased when the fluorinating temperature was enhanced or the fluorinating time was prolonged and then was apt to be invariable. The attenuation of the polymer optical fiber (POF) was obviously reduced after PMMA POF was surface fluorinated. Finally, the mechanism of reducing attenuation of POF is discussed. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2369–2372, 2005
Effect of electron donors on 1,3‐butadiene polymerization by a Ziegler–Natta catalyst based on neodymium
Authors: Coutinho Fernanda M. B. , Rocha Tereza C. J. , Mello Ivana L. , Nunes Denise S. S. , Soares Bluma G. , Costa Marcos A. S. 
Published: September 2005

AbstractHigh‐cis polybutadiene produced by catalyst systems based on a rare earth is an elastomer used to produce green tires. This type of tire presents lower rolling resistance, which allows higher fuel economy, and thus fewer chemical compounds are discharged into the atmosphere. In this work, the influence of electron donors [tetrahydrofuran (THF) and tetramethylethylenediamine (TMEDA)] present in the polymerization solvent on the microstructure and molecular weight characteristics of the polybutadiene produced by neodymium catalysts was studied. The catalyst synthesis was carried out in glass bottles for 1 h at a temperature between 5 and 10°C. The catalyst components were diisobutylaluminum hydride, neodymium versatate, and tert‐butyl chloride. The polymerization reaction was carried out for 2 h. The reaction temperature was kept at 70± 3°C. The addition of TMEDA or THF above a determined concentration reduced the catalytic activity, molecular weight, and concentration of cis‐1,4 units (<96%), whereas the polydispersity increased. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2539–2543, 2005
Tensile mechanical properties of sulfonated poly(ether ether ketone) (SPEEK) and BPO4/SPEEK membranes
Authors: Reyna‐Valencia A. , Kaliaguine S. , Bousmina M. 
Published: September 2005

AbstractA study to evaluate the tensile mechanical properties of sulfonated poly(ether ether ketone) (SPEEK) and BPO4/SPEEK composite membranes has been carried out. It is aimed to give an assessment of these materials for applications in proton exchange membrane fuel cells. The stress–strain response of the membranes was measured as a function of the degree of sulfonation (DS) and the filler–matrix ratio. In addition, the effects of immersion in water at various temperatures were explored in situ by means of a homemade testing chamber fitted to the tensile analyzer. The results indicate that the DS has an important influence on the final mechanical behavior of the membranes. The introduction of the BPO4 solid filler leads to deterioration in mechanical performance compared to unfilled SPEEK. A general picture of the microstructural features influencing the mechanical properties of SPEEK and BPO4/SPEEK membranes is proposed. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 2380–2393, 2005