bluuebunny/crossref_metadata_2025_split huggingface dataset:
A great pioneer of clinical science remembered: Introduction to the special issue in honor of Paul E. Meehl
Authors: Lilienfeld Scott O. , Waller Niels G. 
Published: July 2005

AbstractAn Erratum has been published for this article in Journal of Clinical Psychology 62(6) 2006, 777 [].In this special issue, the seminal contributions to clinical psychology of Paul E. Meehl, who passed away in 2003, are commemorated. The nine articles comprising this special issue chronicle Meehl's remarkable intellectual biography and examine his influence on diverse domains of psychology, including the clinical versus actuarial prediction debate, the cognitive activity of the clinician, personality assessment and trait theory, the etiology of schizophrenia, the shortcomings of statistical significance testing, and the use of metascientific methods to evaluate competing models of human nature. These articles illustrate not only Meehl's legendary brilliance but also his pivotal role in forcing clinical psychologists to think more clearly and incisively about their subject matter. © 2005 Wiley Periodicals, Inc. J Clin Psychol 61: 1201–1207, 2005.
Essential Paul Meehl lessons for personality assessment psychology
Authors: Harkness Allan R. 
Published: July 2005

AbstractThe author presents four essential Meehl lessons for personality assessment. First, Meehl's particular form of the integration of science and practice is described. Second, by outlining Meehl's Hedonic Capacity conjecture, Meehl's contribution to the inclusion of personality individual differences in generating the full clinical picture and in planning treatment is recognized. The third Meehl lesson is on the nature and importance of theory in test development and application programs. The fourth Meehl lesson is a more general epistemological lesson for psychology. Meehl's role in destroying the fantasy of an easy methodological formula for a scientific psychology is described. His program of taxometric research is shown to be an example of demanding greater material implications from theory. Meehl's corroboration index is described and contrasted with the p value of statistical significance testing. © 2005 Wiley Periodicals, Inc. J Clin Psychol 61: 1277–1294, 2005.
Utilization of waste gas containing methyl chloride from 2,2‐dichlorovinyldimethyl‐phosphate (DDVP) production
Authors: Aydın Adnan , Afşar Hüseyin 
Published: July 2005

AbstractMethyl chloride is a major waste in the production of 2,2‐dichlorovinyldimethylphosphate (DDVP) and its emissions need to be treated for environmental protection. The use of methyl chloride as a raw material for several industrial products is a solution to reduce the effects of the pollutant. Quantitative methyl chloride conversions into both methanol and 2‐methoxynaphthalene have been investigated and the milestones of full‐scale industrial applications are given. Copyright © 2005 Society of Chemical Industry
Relationship between vestibular lamina, dental lamina, and the developing oral vestibule in the upper jaw of the field vole (Microtus agrestis, Rodentia)
Authors: Witter Kirsti , Pavlikova Hana , Matulova Petra , Misek Ivan 
Published: July 2005

AbstractFormation of the oral vestibule is ignored in most studies on tooth development, although dental and vestibular lamina are closely related to each other. Knowledge about morphogenetic processes shaping the oral vestibule is missing almost completely. The aim of this study was to assess the developmental relationship between dental and vestibular lamina as well as formation of the oral vestibule in the upper jaw of the field vole (Microtus agrestis), a small rodent representing an attractive model species for comparative dental studies. Three‐dimensional reconstruction revealed that the upper vestibular lamina of the vole joins the antemolar part of the diastemal dental lamina, similar to mouse. Later, this lamina complex regresses and the vestibular lamina is separated from the molar epithelium. Participation of the vestibular lamina in dental lamina formation, as hypothesized for mouse, therefore remains unclear. Except for increased apoptosis in the regressing diastemal dental lamina, spatial segregation of mitoses or apoptoses could be detected neither in the jaw arch epithelium nor in the adjacent mesenchyme. Therefore, in contrast to tooth primordia, apoptosis and mitosis seem to play a minor role in shaping of the upper oral vestibule. The buccal vestibule develops secondarily, probably in consequence of general growth of the head and localized differentiation of cells. J. Morphol. © 2005 Wiley‐Liss, Inc.
Simple measurement of gluconeogenesis by direct 2H NMR analysis of menthol glucuronide enrichment from 2H2O
Authors: Ribeiro Angela , Caldeira M. Madalena , Carvalheiro Manuela , Bastos Margarida , Baptista Carla , Fagulha Ana , Barros Luisa , Barosa Cristina , Jones John G. 
Published: July 2005

AbstractThe contribution of gluconeogenesis to fasting glucose production was determined by a simple measurement of urinary menthol glucuronide (MG) 2H enrichment from 2H2O. Following ingestion of 2H2O (0.5% body water) during an overnight fast and a pharmacological dose (400 mg) of a commercial peppermint oil preparation the next morning, 364 μmol MG was quantitatively recovered from a 2‐h urine collection by ether extraction and a 125 μmol portion was directly analyzed by 2H NMR. The glucuronide 2H‐signals were fully resolved and their relative intensities matched those of the monoacetone glucose derivative. The pharmacokinetics and yields of urinary MG after ingestion of 400 mg peppermint oil as either gelatin or enteric‐coated capsules 1 h before breakfast were quantified in five healthy subjects. Gelatin capsules yielded 197 ± 81 μmol of MG from the initial 2‐h urine collection while enteric‐coated capsules gave 238 ± 84 μmol MG from the 2‐ to 4‐h urine collection. Magn Reson Med 54:429–434, 2005. © 2005 Wiley‐Liss, Inc.
In vivo diffusion weighted 19F MRI using SF6
Authors: Pérez‐Sánchez José M. , de Alejo Rigoberto Pérez , Rodríguez Ignacio , Cortijo Manuel , Peces‐Barba Germán , Ruiz‐Cabello Jesús 
Published: July 2005

AbstractDiffusion weighted 19F images of rat lung in vivo using SF6 are presented. Projection‐reconstruction images were acquired by filling the rat lung with a mixture of SF6 and air, during 64 successive apneas. Each apnea lasted for 6 s, the time required to perform 100 accumulations of each k‐space radial phase step for the five values of the diffusion gradient (TR = 10 ms). After diffusion images were acquired, an apparent diffusion coefficient (ADC) map was generated, yielding an average value for the ADC of 2.22 × 10‐6 m2/s and SD for ADC values of 1.27 × 10‐6 m2/s. To the best of our knowledge, this is the first in vivo diffusion weighting imaging application and the first ADC map obtained using 19F MRI. Magn Reson Med 54:460–463, 2005. © 2005 Wiley‐Liss, Inc.
Detection of glutamate in the human brain at 3 T using optimized constant time point resolved spectroscopy
Authors: Mayer Dirk , Spielman Daniel M. 
Published: July 2005

AbstractA CT‐PRESS sequence was implemented on a 3‐T MR scanner and optimized for the detection of the C4 resonance of glutamate. By simulating the sequence using the full density matrix it was found that 121 chemical shift encoding steps in t1 with an increment Δt1 = 1.6 ms were sufficient to separate the glutamate C4 resonance. The simulations also showed that the highest signal‐to‐noise ratio was achieved at an average echo time of 131 ms. When using an eightfold undersampling scheme in f1 in order to reduce the minimum total measurement time, the average echo time was 139 ms with 17 encoding steps (Δt1 = 12.8 ms). The sequence was tested on phantoms containing solutions of various brain metabolites and on healthy human volunteers. Besides resolving glutamate, other resonances detected in vivo comprised N‐acetyl aspartate, total creatine, choline containing compounds, and myo‐inositol. However, glutamine resonances could not be resolved due to severe signal overlap from glutamate and N‐acetyl aspartate. Magn Reson Med 54:439–442, 2005. © 2005 Wiley‐Liss, Inc.
Dysmorphic neuromuscular junctions associated with motor ability in cerebral palsy
Authors: Theroux Mary C. , Oberman Karyn G. , Lahaye Justine , Boyce Bobbie A. , DuHadaway David , Miller Freeman , Akins Robert E. 
Published: July 2005

AbstractCerebral palsy (CP) is the most prevalent neurologic disease in children and a leading cause of severe physical disability. Research and clinical experience indicate that children with CP have abnormal neuromuscular junctions (NMJs), and we present evidence that nonapposition of neuromuscular junction components is associated with the severity of motor system deficit in CP. Leg muscle biopsies collected from ambulatory (n = 21) or nonambulatory (n = 38) CP patients were stained in order to detect acetylcholine receptor (AChR) and acetylcholine esterase (AChE). Image analysis was used to calculate the extra‐AChE spread (EAS) of AChR staining to estimate the amount of AChR occurring outside the functional, AChE‐delimited NMJ. Nonambulatory children exhibited higher average EAS (P = 0.025) and had a greater proportion of their NMJs with significantly elevated EAS (P = 0.023) than ambulatory children. These results indicate that physical disability in children with CP is associated with structurally dysmorphic NMJs, which has important implications for the management of CP patients, especially during surgery and anesthesia. Muscle Nerve, 2005
Terminal Schwann cell structure is altered in diaphragm of mdx mice
Authors: Personius Kirkwood E. , Sawyer Robert P. 
Published: July 2005

AbstractThe diaphragm muscle of the mdx mouse is a model system of Duchenne muscular dystrophy, since it completely lacks dystrophin and shows severe fiber necrosis and loss of specific muscle force by 4–6 weeks of age. Changes in neuromuscular junction structure also become apparent around 4 weeks including postsynaptic acetylcholine receptor declustering, loss of postsynaptic junctional folds, abnormally complex presynaptic nerve terminals, and muscle fiber denervation. Normally, terminal Schwann cells (TSCs) cap both nerve terminals and acetylcholine receptors at the neuromuscular junction, and play a crucial role in regeneration of motor axons following muscle denervation by guiding axons to grow from innervated junctions to nearby denervated junctions. However, their role in restoring innervation in dystrophic muscle is unknown. We now show that TSCs fail to cap fully the neuromuscular junction in dystrophic muscle; TSCs extend processes, but the organization of these extensions is abnormal. TSC processes of dystrophic muscle do not form bridges from denervated fibers to nearby innervated endplates, but appear to be directed away from these endplates. Adequate signaling for TSC reactivity is present, since significant muscle fiber denervation and acetylcholine receptor declustering are present. Thus, significant structural denervation is present in the diaphragm of mdx mice and the ability of TSCs to form bridges between adjacent endplates to guide reinnervation of muscle fibers is impaired, possibly attenuating the ability of dystrophic muscle to recover from denervation and ultimately leading to muscle weakness. Muscle Nerve, 2005
Signaling at the vertebrate synapse: New roles for embryonic morphogens?
Authors: Salinas Patricia C. 
Published: July 2005

AbstractThe formation of synapses is critical for functional neuronal connectivity. The coordinated assembly at both sides of the synapse is fundamental for the proper apposition of the neurotransmitter release machinery on the presynaptic neuron and the clustering of neurotransmitter receptors and ion channels on the receptive postsynaptic cell. This process requires bidirectional communication between the presynaptic neuron and its postsynaptic target, another neuron, or muscle fiber. Extracellular signals such as WNT, TGF‐β, and FGF factors are emerging as key target‐derived signals required for the initial stages of synaptic assembly. Studies in invertebrates are also providing new insights into the function of these signals in synaptic growth and homeostasis. During early embryonic patterning, WNT, TGF‐β, and FGF factors function as typical morphogens in a concentration‐dependent manner to regulate cell fate decisions. This mode of action raises the provocative idea that these same morphogens might also provide a coordinate system for axons to establish the distance to their targets during axon guidance and synapse formation. © 2005 Wiley Periodicals, Inc. J Neurobiol 64: 435–445, 2005
Morphogen signaling at the vertebrate growth cone: A few cases or a general strategy?
Authors: Bovolenta Paola 
Published: July 2005

AbstractAxon navigation relies on the competence of growth cones to sense and interpret attractive and repulsive guidance cues present along their trajectory. For most neurons, this process is mediated by a limited number of conserved families of ligand‐receptor signaling systems, including Ephrin/Eph, Netrins/DCC‐Unc5, Slits/Robo, and Semaphorins/Plexin‐Neuropilin. Recent studies have demonstrated that some neurons respond also to well‐known secreted signaling molecules, best known for their roles as morphogens, such as BMP7, SHH, FGF8, and Wnt. Thus, retina ganglion cell axon navigation is influenced by FGF, SHH, and possibly BMP signaling. Similarly, commissural neurons in the spinal cord respond sequentially to the activity of BMP, SHH, and Wnt to extend toward and away from their intermediate target, the floor plate. The data that support this conclusion will be summarized and how morphogens may signal at the growth cone will be discussed. © 2005 Wiley Periodicals, Inc. J Neurobiol 64: 405–416, 2005
Mechanisms of morphogen movement
Authors: Strigini Maura 
Published: July 2005

AbstractMorphogens are defined as signaling molecules that are produced locally, yet act directly at a distance to pattern the surrounding field of cells in a concentration‐dependent manner. In recent years many laboratories have devoted their attention to how morphogens actually reach distant cells. Several models have been proposed, including diffusion in the extracellular space and planar transcytosis. A combination of genetic, developmental, and cell‐biological approaches have been taken to tackle this issue. I will present the models and discuss the types of experiments that have been designed to test them. It stands out that most of the work has been carried out in Drosophila. Morphogens contribute to patterning of the vertebrate nervous system, and the same signaling molecules have recently been shown to play important, possibly instructive, roles in axon guidance. Little, if anything, is known about the movement of morphogens in the context of nervous system development. The long‐standing tradition of biophysical studies on diffusion in the brain extracellular space, along with the sophisticated in vitro culture systems developed in neurobiology laboratories, may provide new tools and ideas to test these models in a new context. © 2005 Wiley Periodicals, Inc. J Neurobiol 64: 324–333, 2005
PRIDE: The proteomics identifications database
Authors: Martens Lennart , Hermjakob Henning , Jones Philip , Adamski Marcin , Taylor Chris , States David , Gevaert Kris , Vandekerckhove Joël , Apweiler Rolf 
Published: July 2005

AbstractThe advent of high‐throughput proteomics has enabled the identification of ever increasing numbers of proteins. Correspondingly, the number of publications centered on these protein identifications has increased dramatically. With the first results of the HUPO Plasma Proteome Project being analyzed and many other large‐scale proteomics projects about to disseminate their data, this trend is not likely to flatten out any time soon. However, the publication mechanism of these identified proteins has lagged behind in technical terms. Often very long lists of identifications are either published directly with the article, resulting in both a voluminous and rather tedious read, or are included on the publisher's website as supplementary information. In either case, these lists are typically only provided as portable document format documents with a custom‐made layout, making it practically impossible for computer programs to interpret them, let alone efficiently query them. Here we propose the proteomics identifications (PRIDE) database (http://www.ebi.ac.uk/pride) as a means to finally turn publicly available data into publicly accessible data. PRIDE offers a web‐based query interface, a user‐friendly data upload facility, and a documented application programming interface for direct computational access. The complete PRIDE database, source code, data, and support tools are freely available for web access or download and local installation.
SPS' Digest: The Swiss Proteomics Society selection of proteomics articles
Authors: Hoogland Christine , Lion Niels , Palagi Patricia M. , Sanchez Jean‐Charles , Tissot Jean‐Daniel 
Published: July 2005

AbstractDespite the consolidation of the specialized proteomics literature around a few established journals, such as Proteomics, Molecular and Cellular Proteomics, and the Journal of Proteome Research, a lot of information is still spread in many different publications from different fields, such as analytical sciences, MS, bioinformatics, etc. The purpose of SPS' Digest is to gather a selection of proteomics articles, to categorize them, and to make the list available on a periodic basis through a web page and email alerts.
Evidence that DL‐3‐aminobutyric acid and acibenzolar‐S‐methyl induce resistance against bacterial head rot disease of broccoli
Authors: Pajot Emmanuel , Silué Drissa 
Published: July 2005

AbstractHead rot of broccoli caused by Pseudomonas marginalis (Brown) Stevens and P. fluorescens Migula is a major disease in Brittany (France). To date, no accession with a satisfactory field resistance has been identified, and available pesticides are not effective in controlling the disease. The aim of this study was to test whether acibenzolar‐S‐methyl (ASM), DL‐3‐aminobutyric acid (BABA) and potassium phosphonate (K2HPO3), known to induce resistance against various diseases, can help protect broccoli against head rot. The susceptible broccoli F1 hybrids Marathon and Shogun were grown in a greenhouse until head formation. They were then sprayed with ASM (0.23 mM AI), BABA (20 mM AI) or potassium phosphonate (37.41 mM AI) until runoff. In one experiment, heads from treated plants were excised, inoculated (104 cfu ml−1) and incubated in Magenta GA7 vessels. In another experiment, heads were inoculated on treated living plants. Disease ratings were made 5 days after inoculation. Antibiotic‐ and water‐treated plants served as controls. Results obtained showed that, on excised treated heads, potassium phosphonate was not protective and disease scores were comparable with those of the water control. BABA‐ and ASM‐treated excised heads were poorly, but significantly, protected. On whole plants with heads attached, the latter two compounds were much more effective. ASM‐induced resistance increased in effectiveness over 8 days after inoculation, whilst that induced by BABA decreased. This result suggests that testing disease resistance inducers on excised broccoli heads is not accurate. ASM and BABA may offer alternative methods for controlling head rot of broccoli. Copyright © 2005 Society of Chemical Industry
New concepts for regio‐ and stereoselective bis‐ and triscyclopropanations of C60
Authors: Hirsch Andreas 
Published: July 2005

AbstractThe synthesis of isomerically multiple adducts of C60 with a defined three‐dimensional structure is still one of the most challenging tasks of exohedral fullerene chemistry. The inherent regioselectivity of successive additions of addends such as malonates to the fullerene's [6,6]‐double bonds is only moderate. In most cases difficult‐to‐isolate mixtures of regioisomers are obtained. The regioselectivity can be significantly improved if multifunctional addends able to undergo two or more additions are allowed to react with C60. Preorganization and minimization of strain energy within the addend skeleton reduce the number of sterically allowed addition patterns. Improved concepts for highly regio‐ and stereoselective bis‐ and triscyclopropanations of C60 are described. Two examples of the bisadditions with complete regioselectivity leading to trans‐2‐ and cis‐2 are presented. Here, the two malonate binding sites are linked by rigid tetraphenylporphyrin and calix‐[4]‐arene spacers. Selective trisadditions were achieved with the easy‐to‐synthesize and easy‐to‐modify tripodal addends 5–7, where the malonates are held together by a focal aryl moiety. Another very elegant approach for bis‐ and trisadditions involves cyclo‐[n]‐alkylmalonates. Selection between addition patterns with and without rotational axes is possible by choosing the right combinations of the flexible alkyl chains connecting the malonates. If alkyl chains of identical lengths are used bis‐ and trisadducts such as 19–21 and 25 with rotational symmetry are formed with high regioselectivity. These addition patterns are avoided if cyclo‐[n]‐malonates containing alkyl chains of different lengths are employed. In this case adducts such as 26 and 27 with Cs‐symmetry are formed. The use of the chiral cyclo‐[3]‐malonate 28 allows for the regio‐ and stereoselective synthesis of the enantiomerically pure e,e,e‐trisadducts 29 and 30 containing an inherently chiral addition pattern with C3‐symmetry. © 2005 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 5: 196–208; 2005: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.20047
Elemental characterization of aerosols in urban and rural locations in Bangladesh
Authors: Boman J. , Gatari M. J. , Wagner A. , Hossain M. I. 
Published: July 2005

AbstractBangladesh became the first country in South Asia to ban the use of lead in gasoline in 1999. In 2003, two‐stroke engine auto rickshaws were banned in the city centre of Dhaka, the capital of Bangladesh and one of the Asian mega‐cities, in an attempt to improve the air quality. In July and August 2003, fine aerosol particles (PM2.5) were collected in Dhaka and in Rangpur in the northern part of the country. The aim was to study the effect of the action and to characterize PM2.5 particles in urban and rural areas of Bangladesh. Sampling was done with a cyclone of Dewell–Higgins type equipped with Teflon filters with a pore size of 3 µm. Day‐ and night‐time filters were collected in an attempt to understand the possible difference in air pollution between the two periods. An energy‐dispersive x‐ray fluorescence (EDXRF) spectrometer with three‐axial geometry was utilized for the analysis of the elemental content of the particles. Large variations of concentrations for most elements in both Dhaka and in Rangpur were observed. Most of the elemental concentrations in Dhaka in daytime were higher than at night whereas the opposite was the case for Rangpur. The concentrations showed a significant influence of human activities and weather. Considerable concentrations of Pb were found despite the official ban of leaded gasoline. Motor transport, especially the two‐stroke engine taxis and elements remobilized by burning, were the major sources identified. This is the first report on elemental concentrations in PM2.5 particles in both Dhaka and Rangpur. Copyright © 2005 John Wiley & Sons, Ltd.