bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational screening of foxtail millet (Setaria italica (L.) P.Beauv.) polyphenols for finding β-secretase (BACE 1) inhibitors that target the amyloidogenic pathway in Alzheimer's disease
Authors: Cheemanapalli Srinivasulu , Golla Ramanjaneyulu , Koyyagura Jagadeeswar Reddy , Pulicherla Yugandhar , Bhardwaj Yashpal , Bhuyan Birina , Taboh Mumtam , Nagayya Shiddamallayya , Saddala Rajeswara Reddy 
Published: November 2023

Abstract

BACKGROUND:
Foxtail millet (FM; Setaria italica (L.) P.Beauv.) is known for its antioxidant and neuroprotective action against Alzheimer's disease (AD); hence the present study aims to screen its polyphenols to find less toxic and potentially effective anti-Alzheimer's drugs.

MATERIALS AND METHODS:
The details about phyto-compounds of FM and the β-secretase enzyme (BACE 1) of AD have been retrieved from the PubChem compound database and protein data bank, respectively. The Patch Dock server was used to carry out docking experiments. Initially, all the FM phytocompounds and reference drug (MK-8931) were subjected to docking, and subsequently, the best-docked complexes were selected based on their binding energy (in kcal/mol). Rule of five and adsorption, distribution, metabolism, excretion, and toxicity (ADMET) of selected compounds were analyzed using various computational tools. The final docking complexes were developed by using PyMOL.

RESULTS:
The molecular docking results revealed that among the 24 polyphenols studied, two compounds, namely N′-p-coumaroyl-N″-caffeoylspermidine (NPCNCS) and di-P-coumaroylspermidine (DPCS), demonstrated strong binding to the active site of β-secretase. and exhibited higher binding energies of -300.75 kcal/mol and -193.41 kcal/mol, respectively, in comparison to the reference drug MK-8931, with a binding energy of -154.36 kcal/mol. These compounds established hydrogen bond interactions with catalytic dyad (Asp 32 and Asp 228) and other accessory interactions with residues of the “flap” hairpin loop and “10s loop” of the β-secretase active site involved in the stabilization of substrate/inhibitor binding. In a nutshell, the NPCNCS and DPCS have shown more robust binding affinity than MK-8931 and docked well into the interior side of the active site. On the other hand, NPCNCS and DPCS have satisfied the RO5 and ADMET filters.

CONCLUSIONS:
The in silico analysis of FM polyphenols revealed that the N′-p-coumaroyl-N″-feruloylspermidine and di-P-coumaroylspermidine compounds exhibited non-toxic, permeability to blood-brain barrier and solid binding affinity toward β-secretase enzyme thereby; these millet compounds might be considered as β-secretase inhibitors for treating AD.
Real-life experiences and barriers to adjuvant chemotherapy in Saudi patients with advanced stage II and stage III colon cancer
Authors: Alyabsi Mesnad S. , Alqarni Anwar H. , Almutairi Adel F. , Alselaim Nahar A. , Algarni Mohammed A. , Alshammari Kanan M. 
Published: November 2023

Abstract

Background:
Colorectal cancer is the most common malignancy in Saudi males and third most common in females. Patients with locally advanced colon cancer may eventually develop metastatic disease if not treated promptly and according to guidelines. The recent National Comprehensive Cancer Network guideline recommends tumor resection followed by adjuvant chemotherapy for stage III and high-risk stage II tumors. Therefore, the objective of this study was to characterize patients with locally advanced colon cancer and identify factors associated with the use of adjuvant chemotherapy and the addition of oxaliplatin in locally advanced colon cancer patients.

Methods:
All patients diagnosed with locally advanced colon cancer at National Guard Health Affairs (NGHA) during 2016-2021 were investigated. Patients’ characteristics were compared using Chi-square and Fisher exact test, whereas predictors of adjuvant chemotherapy/Oxaliplatin use were identified using univariate and multivariate logistic regression.

Results:
Out of 222 patients diagnosed with locally advanced colon cancer, 133 received adjuvant chemotherapy. Factors associated with adjuvant chemotherapy administration were age and smoking status. In the multivariable analysis, older patients were less likely to receive oxaliplatin than younger patients. Stage III patients diagnosed during 2019-2021 had 5.61 times higher odds of receiving oxaliplatin.

Conclusion:
The findings of this study show that older patients and smokers are less likely to be treated with adjuvant chemotherapy. Moreover, age as well as diagnosis year were important determinants of oxaliplatin administration in stage III locally advanced colon cancer patients.
Mediterranean diet as a modifiable risk factor for age-related macular degeneration: A systematic review and meta-analysis
Authors: Angelia Maria , Amelia Yufilia Suci , Pratama Kevin Gracia 
Published: November 2023

Objectives:
Age-related macular degeneration (AMD) is a chronic and degenerative disease of the retina that leads to irreversible blindness. There is no proven effective treatment for early AMD and advanced AMD. Mediterranean diet (MD) has been linked to reducing the risk or delaying the progression of AMD. Therefore, in this study, we aim to investigate the potential of MD as a modifiable risk factor for AMD.

Materials and Methods:
A systematic search was performed in three databases: PubMed, EBSCO host, and Proquest. We search for studies that determine the association of MD in AMD. Then, we pooled the data for meta-analysis.

Results:
Eight studies were included in our systematic review. Seven studies were included for meta-analysis. Subjects with medium–high (hazard ratio [HR] 0.82; 95% confidence interval [CI]: 0.75–0.90) adherence to the MD showed a reduced risk of developing AMD. Moreover, medium adherence AMD shows a significant and inverse relationship with the progression to advanced AMD (HR: 0.87; 95% CI: 0.81–0.93). Although it is still inconsistent, the reduction appears stronger for geographic atrophy than for neovascular AMD.

Conclusion:
Adhering to the MD, particularly at a medium to high level, appears to confer a protective effect against AMD. The sub-analysis demonstrates even that there is a protective effect associated with moderate adherence against advanced AMD. The presence of considerable heterogeneity within the results warrants cautious interpretation. Further research is needed to enhance our understanding.
A Novel Approach for Earthquake Prediction Using Random Forest and Neural Networks
Authors: Agarwal Nidhi , Arora Ishika , Saini Harsh , Sharma Ujjwal 
Published: November 2023

INTRODUCTION: This research paper presents an innovative method that merges neural networks and random forest algorithms to enhance earthquake prediction.
OBJECTIVES: The primary objective of the study is to improve the precision of earthquake prediction by developing a hybrid model that integrates seismic wave data and various extracted features as inputs.
METHODS: By training a neural network to learn the intricate relationships between the input features and earthquake magnitudes and employing a random forest algorithm to enhance the model's generalization and robustness, the researchers aim to achieve more accurate predictions. To evaluate the effectiveness of the proposed approach, an extensive dataset of earthquake records from diverse regions worldwide was employed.
RESULTS: The results revealed that the hybrid model surpassed individual models, demonstrating superior prediction accuracy. This advancement holds profound implications for earthquake monitoring and disaster management, as the prompt and accurate detection of earthquake magnitudes is vital for effective mitigation and response strategies.
CONCLUSION: The significance of this detection technique extends beyond theoretical research, as it can directly benefit organizations like the National Disaster Response Force (NDRF) in their relief efforts. By accurately predicting earthquake magnitudes, the model can facilitate the efficient allocation of resources and the timely delivery of relief materials to areas affected by natural disasters. Ultimately, this research contributes to the growing field of earthquake prediction and reinforces the critical role of data-driven approaches in enhancing our understanding of seismic events, bolstering disaster preparedness, and safeguarding vulnerable communities.
Challenges with Gamification in Higher Education: A Narrative Review with Implications for Educators and Policymakers
Authors: Fuchs Kevin 
Published: November 2023

This narrative review critically examines the application of gamification in higher education. Gamification, the integration of game elements into learning, is increasingly used to enhance student engagement and motivation. However, the effectiveness of gamification depends on its alignment with learning objectives. Superficial use of game elements, such as irrelevant badges, can hinder meaningful learning outcomes. Moreover, over-reliance on extrinsic rewards can lead to short-term motivation but may compromise deep learning. Additionally, a competitive culture fostered by gamification might hinder collaboration and stress individual achievement. To harness gamification's benefits, educators must carefully design game mechanics to promote collaboration, select suitable activities, and consider diverse learning styles. This review underscores the need for thoughtful integration of gamification and the importance of evaluating its impact on pedagogical goals in higher education. The article concludes by providing implications for research and practice.

Received: 29 August 2023 | Revised: 6 November 2023 | Accepted: 8 November 2023

Conflicts of Interest
Kevin Fuchs is an editorial board member for International Journal of Changes in Eduaction, and was not involved in the editorial review or the decision to publish this article. The author declares that he has no conflicts of interest to this work.

Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
Analisis Kesalahan Siswa dalam Menyelesaikan Soal Matematika dengan Menggunakan Metode Newman
Authors: Nuraina Nuraina , Rohantizani Rohantizani , Suryani Hawa Muzaifa 
Published: November 2023

Tujuan dari penelitian ini adalah untuk menjelaskan berbagai jenis kesalahan yang dilakukan siswa Jabal Nur dari kelas XI-1 MAS ketika mereka menyelesaikan soal matematika dalam bentuk cerita materi barisan dan deret yang menggunakan metode Newman. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Data dikumpulkan melalui tes tertulis dan wawancara. Siswa kelas XI-1 MAS Jabal Nur, totalnya 22 siswa, adalah subjek penelitian ini. Hasil penelitian menunjukkan bahwa (a) persentase kesalahan membaca siswa sebesar 46,25% (b) persentase kesalahan memahami masalah sebesar 77,5%, (c) persentase kesalahan transformasi sebesar 45%, (d) persentase kesalahan keterampilan proses sebesar 45%, dan (e) persentase kesalahan penulisan jawaban akhir sebesar 61,25%. Faktor-faktor penyebab kesalahan siswa adalah tidak terlalu memahami maksud dari soal, tidak mengetahui permasalahan yang terdapat pada soal, lupa menuliskan jawaban, terburu-buru dalam menuliskan jawaban, tidak paham dengan rumus yang seharusnya digunakan, tidak teliti dalam melakukan operasi perhitungan, terjadi kesilapan ketika menentukan hasil akhir.
Implementation of Smart Corn Planter (SCP) to Support Food Security in Agricultural Area Gondosuli Village Probolinggo Regency
Authors: Iskandar Syah Abdullah , Tri Handoko Wahyu , Zainul Falah Moh. , Kurniawan Ryan , Hafid Ahmad , Dwi Prasetya Didik 
Published: November 2023

Gondosuli Village is located in Pakuniran, Probolinggo, East Java, and has an area of 11.66 km² (4.50 sq mi), consisting of agricultural land, settlements, public facilities, and mountain forests beneath Mount Rengganis. crops in Gondosuli village are dominated by rice and corn during the rainy season, and tobacco during the dry season. Corn has an important role as a commercial commodity in this village because it is used as animal feed, industrial raw materials, and also as a food ingredient. The process of planting seeds in Gondosuli village itself is still classified as using the traditional method where only using wood as a seed hole maker, and the seeds are inputted by human labor, and the distance between the seeds is only estimated by the farmer, in this way the seed planting process requires a lot of effort and time. big. A push corn planting tool or Smart corn planter is a tool used to grow corn efficiently and effectively on agricultural land. By using the Smart corn planter, farmers can grow corn quickly and more easily, and save effort and time. In addition, this tool can also help produce regular and even corn crops.
Keywords: Smart Corn Planter (SCP), Gondosuli Village, Support Food Security
Implementation of Appropriate Technology Polycrystalline Photovoltaic as New Renewable Alternative Energy in Public Street Lighting (PJU) at Pakuniran Probolinggo Area
Authors: Azhari Muhammad Holqi Rizki , Handoko Wahyu Tri , Falah Moh. Zainul , Rahmat Busono Milzam , Faraasyatul ‘Alam Ghasa , Sucipto Sucipto , Umam Khotibul 
Published: November 2023

Public road lighting (PJU) in the Pakuniran area, Probolinggo, East Java, more precisely in Gondosuli Village, is not sufficient. An environment without street lighting will be like a dead zone and can occur in many cases of crime, and traffic accidents and will hurt social life at night. Therefore, the community service team at the State University of Malang (UM) through student service provided a solution to reaching the road by utilizing new, renewable energy from polycrystalline solar panels to turn on the lights at night. The results of observations and site surveys show that several points require PJU installation with polycrystalline technology. The implementation carried out in Gondosuli Village was carried out in several stages, namely: observation, preparation of PJU designs, training and maintenance, performance testing, and evaluation tools. This activity, which was completed within 2 months, resulted in 5 PJUs being placed at several points with minimal lighting conditions and received a positive response from the community.
Keywords: Public Street Lighting, Polycrystalline Photovoltaic, Gondosuli Village
Aplikasi BGA UMAHA Sebagai Pendeteksi Gas Darah Disertai Interpretasi Hasil Berbasis Android
Authors: Yusmiati Siti Nur Husnul , Yuntarso Anton , Nugraha Jusak 
Published: November 2023

Derajat keasaman tubuh dapat mengalami peningkatan (alkalosis) dan penurunan (asidosis) akibat gangguan keseimbangan kation anion serta kegagalan transportasi dan produksi makromolekul sehingga permasalahan suatu fungsi sel dapat terjadi. Afinitas Ferro(Fe2+) yang terikat oleh molekul histidin dalam struktur haemoglobin terhadap oksigen akan terganggu jika pH darah arteri lebih kecil dari 7,35 atau lebih besar dari 7,45. Tingkat gangguan asam basa tubuh dapat diukur menggunakan alat gas darah. Pada saat pertama kali muncul alat gas darah hanya menyajikan hasil pH, pCO2, dan pO2dimana parameter yang lain seperti HCO3, BE, O2saturasi harus diplot terlebih dahulu menggunakan tabel Siggard Anderson. Perkembangan teknologi, mendukung terciptanya alat gas darah yang terintegrasi dengan logaritma bahasa program parameter hitungan, sehingga nilai HCO3,Base Excess Extra Cellular Fluid(BEecf), Base Excess Blood(BEB), O2 saturasi, dan parameter lain dapat termunculkan setelah didapatkan nilai pH, pCO2, dan pO2. Basis penelitian ini adalah pembuatan aplikasi mobile BGA UMAHA versi 0.1.0 yang dapat memberikan hasil interpretasi secara cepat, tepat, praktis, dan murah dengan tambahan inputan suhu tubuh dan kadar Hb pasien untuk mendapatkan nilai BEBase dan O2saturasi yang diperlukan, dengan demikian diharapkan permasalahan stabilitas alat, tingkat kelelahan klinisi dan efisiensi biaya dapat dilakukan. Kesimpulan pada penelitian ini adalah aplikasi mobile BGA UMAHA versi 0.1.0 dapat memunculkan parameter hitungan dengan inputan suhu dan kadar Hb dengan akurasi tinggi tanpa dipengaruhi nilai LOD alat serta dapat memunculkan interpretasi hasil.
PENYULUHAN SISTEM PENJERNIHAN AIR BERSIH PADA WARGA PASIR CURUG DESA CIKAKAK
Authors: Muhammad Hidayat  , Abdul Aziz  , Angga Dwi Nugraha  , Sansan  , Mohammad Rifal Fadillah  
Published: November 2023

Air merupakan kebutuhan utama bagi makhluk hidup. Manusia sendiri sangat membutuhkan air bersih untuk kehidupan sehari-harinya. Di Kampung Pasir Curug warga masih memanfaatkan sungai untuk memenuhi kebutuhan airnya. Kondisi sungai yang di jadikan sumber air sangat jauh dan masih cukup bersih, namun pada waktu tertentu air akan sedikit surut dan terlihat keruh. Salah satu Program Kerja Kelompok 1 pada Kuliah Kerja Nyata yang di adakan di Desa Cikakak, Kecamatan Cikakak Kabupaten Sukabumi, Jawa Barat bertujuan untuk melakukan penyuluhan air bersih dan membantu memperbaiki bak penampungan air warga Pasir Curug. Besar harapan dari kegitatan ini akan mampu meningkatkan pengetahuan warga Kampung Pasir Curug tentang air yang sehat, dan juga dapat mengetahui bahan apa saja yang dapat digunakan untuk menjernihkan air. Metode yang digunakan adalah penyuluhan kepada warga Pasir Curug, Desa Cikakak dan juga memberi bantuan berupa bahan dan tenaga untuk memperbaiki bak penampungan air yang sudah ada. Hasil dari Program Kerja ini yaitu meningkatkan pengetahuan warga tentang pentingnya air bersih dalam kehidupan. Selain itu warga juga dapat memperbaiki bak penampungan air yang sudah rusak menjadi layak lagi digunakan.

Kata kunci: air bersih,Warga Pasir Curug, bak penampungan air.
PROBLEMATIC ISSUES OF THE SUBJECT COMPOSITION OF NEIGHBORHOOD LEGAL RELATIONS
Authors: ЕГУБОВА Т.В. 
Published: November 2023

Соседские отношения остаются фрагментарно урегулированными в отечественной правовой системе. Цель статьи – предложить решения проблемных вопросов субъектного состава соседских правоотно- шений. Автор приходит к выводу, что в целях защиты прав и законных интересов соседей целесообразно рас- сматривать в качестве субъектов соседских правоотношений всех граждан и юридические лица, у которых присутствует соприкосновение интересов в процессе использования помещения, земельного участка, нахо- дящегося в собственности, аренде, найме и т. д., при условии их нахождения в непосредственной близости и (или) наличия общего имущества. Значимость статьи обусловлена выработанными предложениями по совер- шенствованию жилищного законодательства Российской Федерации.
Neighborhood relations remain fragmentally regulated in the domestic legal system. The purpose of the article is to offer solutions to problematic issues of the subject composition of neighborhood legal relations. The author comes to the conclusion that in order to protect the rights and legitimate interests of neighbors, it is advisable to consider as subjects of neighborhood legal relations all citizens and legal entities who have a contact of interests in the process of using premises, land owned, leased, rented, etc., provided they are in close proximity and (or) the presence of common property. The significance of the article is due to the developed proposals for improving the housing legislation of the Russian Federation.
ANALYSIS OF CHANGES IN THE LEGAL REGULATION OF FINANCIAL TRANSACTIONS IN THE CONTEXT OF CIVIL LAW REFORM
Authors: КАРПОВ А.В. 
Published: November 2023

Данная научная статья посвящена исследованию изменений в правовом регулировании фи- нансовых сделок, принятых в России в последние годы. В статье описываются новые нормы, их влияние на рынок финансовых инструментов, и приводятся рекомендации по их применению. Основные выводы статьи свидетельствуют о необходимости постоянного совершенствования правового регулирования для обеспече- ния стабильности на финансовом рынке.
This scientific article is devoted to the study of changes in the legal regulation of financial transactions adopted in Russia in recent years. The article describes the new rules, their impact on the market of financial instruments and provides recommendations for their application. The main conclusions of the article indicate the need for continuous improvement of legal regulation to ensure stability in the financial market.
Rezension von: Claus, Helmut, Sächsische Kleinpressen im Dienste der Reformation ...
Authors: Franz Gunther , Claus Helmut 
Published: November 2023

Helmut Claus: Sächsische Kleinpressen im Dienste der Reformation. Das Schaffen von Gabriel Kantz in Altenburg (1524 bis 1527?). In: Martin Luther. Leben, Werk, Wirkung. Berlin 1983. S. 347-365.
Ders.: Die Zwickauer Drucke des 16. Jahrhunderts. Teil 1: Johann Schönsperger 1523-1528. Gabriel Kantz 1527-1529. (= Veröffentlichungen der Forschungsbibliothek Gotha, H. 23). Gotha: Forschungsbibliothek 1985. 178 S.
Kajian geokimia Air asam Tambang Desa Manjelutung Kecamatan Sesayap Kalimantan Utara
Authors: Kurniawan Evy 
Published: November 2023

ABSTRAK
Kajian Geokimia ini dilakukan untuk mendapatkan gambaran, karaketerisitik serta penyebaran sifat potensi keasamanan material batuan-batuan penutup di area Pit.
Beberapa tahapan pekerjaan yang dilakukan dalam kajian ini meliputi pemboran full coring, penyampelan batuan untuk uji NAG, pengujian laboratorium, penarisan serta penentuan estimasi prosentasi material bersifat PAF dan NAF.
Berdasarkan tinjauan Geologi, maka formasi regional di area daerah penelitian adalah berupa Formasi Tabul berumur Miosen. Adapun secara lokal maka litologi penyusun di area daerah penelitian terdiri dari perulangan perlapisan batulempung dan batupasir dengan sisipan batulanau dan batubara.
Total lubang bor yang digunakan dalam kajian ini berjumlah 4 lubang, yaitu GT-09 dan GT-04 di sisi selatan, serta GT-01 dan GT-05 di sisi Utara.
Metode penyampelan untuk uji NAG adalah berupa komposit dengan total sampel berjumlah 12 sampel, mewakili semua variasi batuan yaitu claystone, sandstone dan siltstone serta berasal dari semua zona batuan penutup dari overburden seam J1 sampai underburden seam E2. Penentuan sifat keasaman batuan dilakukan berdasarkan uji NAG dengan menggunakan SNI 13-7170-2006.
Berdasarkan karakter keasaman dari setiap lapisan batuan tersebut, maka didapatkan bahwa material PAF memiliki prosentase 90%, sedangkan material bersifat NAF memiliki prosentase sebesar 10%.
Untuk menjaga tidak terjadinya air asam tambang adalah dengan melakukan enkapsulasi, yaitu dengan cara sekuen penimbunan material batuan penutup dengan memisahkan antara batuan berpotensi PAF dengan batuan berkarakter NAF.

Kata Kunci: Air asam tambang, PAF/NAF, Enkapsulasi, AAT, NAG