bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPROVING THE RELIABILITY OF BODY ASSEMBLY LINE EQUIPMENT
Authors: AMASAKA KAKURO , SAKAI HIROHISA 
Published: October 2004

It is necessary to establish higher levels of equipment reliability in a short time, the market demands ever shorter lead times for the release of new models. Also, the demand for new-model cars is very strong immediately after their introduction. The conventional method for enhancing equipment reliability is by screening alone. However, this requires screening operations on production lines and so has been an obstacle to line production and prevented shortening of lead times. We are now able to dramatically enhance equipment reliability in a very short time by detecting failure modes and forecasting the number of occurrences using a scientific technique based on reliability engineering.
REVIEW OF FAN LIFE EVALUATION PROCEDURES
Authors: KIM SUNG , VALLARINO CARLOS , CLAASSEN ALAN 
Published: October 2004

Improving the reliability of air cooled electronic equipment must include focusing on the life expectancy of the fans or blowers. Evaluating fan failure behavior, however, is not a trivial problem, as vendors report very little information on this subject. Even when product literature provides such data, one vendor’s results are generally impossible to compare with another’s due to different test procedures, different assumptions, and different calculation methods, not all of which are explicitly defined. This paper is designed to help thermal and component evaluation engineers who have been assigned the task of sorting through these sometimes conflicting, often incompatible, claims regarding fan quality. We start with a definition of fan failure in terms of rotational speed, running current, and acoustic noise. Some basic statistical principles, such as Weibull hazard rate, Mean Time To Failure (MTTF) and L10 life, are presented in the reliability section, leading into methods for the estimation of fan life. Booser’s equation for grease life is included and its limitations for modern greases are noted; the standard equation for bearing rating life is also covered. To verify calculated fan life estimates, a designed experiment may be performed. A basic formula for the design of a fan life experiment is given, together with a brief analysis of published failure data from such an experiment. Most fan life tests are conducted under stress conditions, such as high temperature, that accelerate fan failures. The final section discusses accelerated life testing, including potential pitfalls. Simulating a mini-textbook, the paper contains valuable everyday reference material, including sample calculations to illustrate the concepts reviewed.
CdTe:In MONOCRYSTAL MODULES FOR ALL-OPTICAL PROCESSING
Authors: PIETRALUNGA S. , BOFFI P. , MARTINELLI M. 
Published: October 2004

The aim of this work is to present the application of photoconductive properties of electro-optical n-doped CdTe:In single crystals to all-optical processing of signals at λ=1550 nm. The mechanism exploits the photogeneration of charge carriers from deep intragap energy levels and their trap-limited drift process under the action of an externally applied cw electric field. An internal space-charge counterfield results that locally shields the electro-optic effect. Different types of free-space architectural elementary modules in CdTe:In have been implemented. A non-coherent wavelength converter, a switching device, a sampler and a time-to-space converter are presented. The nanosecond regime has been reached.
THE RAMAN EFFECT AND SOLITONS IN AN ELLIPTICAL OPTICAL FIBER
Authors: MALOMED BORIS A. , TASGAL RICHARD S. 
Published: October 2004

We derive a general system of coupled nonlinear Schrödinger equations, describing light in a bimodal optical fiber, taking into account the quasi-instantaneous Raman effect, group-velocity birefringence, phase-velocity birefringence, and optical activity, and for light with general ellipticity. The Raman coefficients prove to obey a relation which depends on the ellipticity. When group-velocity birefringence and optical activity are both non-zero, polarization couples to the changing frequency, so soliton polarization cannot be held constant in this case. Without optical activity, there are solitons with constant polarization either entirely in one polarization (“simple”) or equally divided between the two polarizations (“vector”). At ellipticity angle 0° to 35.3°, the simple solitons are stable and the vector solitons are unstable, and vice versa for ellipticity angle 35.3° to 90°. With optical activity, the polarization can be constant, but with a rather more complex form. Stability is also examined, and bistability is found in some circumstances.
Weathering of the primary rock-forming minerals: processes, products and rates
Authors: Wilson M. J. 
Published: October 2004

AbstractThis paper describes the ways in which the major rock-forming primary minerals (olivine, pyroxenes, amphiboles, feldspars, micas and chlorites) break down during weathering, the products that develop during this breakdown and the rates at which this breakdown occurs. The perspective chosen to illustrate this vast topic is that of the residual soil weathering profile. Different physical and chemical conditions characterize the various parts of such a profile. Thus, in the slightly weathered rock at the base of the profile, mineral weathering will take place in microfissures and narrow solution channels and the capillary water in such spatially restricted volumes may be expected to be close to equilibrium with the primary mineral. In these circumstances, the weathering product formed may be closely related to the primary mineral both compositionally and structurally. The saprolite higher up in the weathering profile may or may not retain the fabric and structure of the original parent rock, but in either case the close relationship observed between primary mineral and weathering product in the slightly weathered rock may be lost. This part of the profile will usually be affected by freely flowing drainage waters, the composition of which will be far from equilibrium with specific primary minerals. Weathering products which do form are likely to reflect the interaction between bulk water and bulk parent material. In the soil profile, the situation will be further complicated by organic ligands derived from decomposing organic matter or from the direct activities of soil microbes or plant roots. Thus, biological weathering will assume a much greater significance in this part of the profile compared with the mainly inorganic processes dominating in the saprolite and the slightly weathered rock. The general nature of any particular weathering profile will reflect the interactions between climate, topography, parent material, soil biota and time and superimposed upon this complexity, when considering how individual primary minerals break down in detail, will be factors related to the nature of the mineral itself. Particularly important in this respect is the inherent susceptibility of the mineral to weathering, which is related to overall chemical composition and structure, as well as the distribution and density of defects, dislocations and exsolution features, which often control the progress of the weathering reaction.
Composition variation of illite-vermiculitesmectite mixed-layer minerals in a bentonite bed from Charente (France)
Authors: Meunier A. , Lanson B. , Velde B. 
Published: October 2004

AbstractMineralogical and chemical variations were studied in the upper half of a 1 m thick discontinuous bentonite bed interlaminated in the Lower Cenomanian sedimentary formations of the northern Aquitaine basin (France). X-ray diffraction patterns obtained from the <2 mm fraction in the Ca and K-saturated states were decomposed and compared to those calculated from decomposition parameters. They revealed the presence of two highly expandable illite-expandable (I-Exp) mixedlayer minerals (MLMs). The relative proportions of the two MLMs evolve steadily with depth leading to the decrease of the cation exchange capacity and of the (Na + Ca) content towards the centre of the bentonite bed. However, the system is essentially isochemical and Mg, Al, Si, K and Fe are roughly constant in the bulk samples. It is thought that the mineralogical zonation results from the initial stages of the smectite formation in an ash layer.In the Ca-saturated state, the expandable component of these MLMs was for the most part homogeneous with the presence of 2 sheets of ethylene glycol molecules in the interlayer. However, the heterogeneous hydration behaviour of these expandable layers was enhanced by the K-saturation test. From this test, the presence of three layer types with contrasting layer charge was evidenced from their contrasting swelling abilities. The C12-alkylammonium saturation test applied to samples in which the octahedral charge had previously been neutralized (Hofmann-Klemen treatment) showed that the tetrahedral charge is located on specific layers. These layers are responsible for the heterogeneous hydration behaviour. Low-charge smectite layers are mostly octahedrally substituted, whereas for intermediate- and high-charge layers this montmorillonitic charge is complemented by additional tetrahedral substitutions (0.30 and 0.35–0.40 charge per O10(OH)2, respectively).
TEM study of mineral transformations in fired carbonated clays: relevance to brick making
Authors: Bauluz B. , Mayayo M. J. , Yuste A. , Fernandez-Nieto C. , Gonzalez Lopez J. M. 
Published: October 2004

AbstractThis study uses transmission electron microscopy (TEM) and analytical electron microscopy (AEM) supported by X-ray diffraction (XRD) and scanning electron microscopy (SEM) to investigate the mineralogical and textural changes produced in carbonated clays by firing. Sample bars were prepared using raw clays composed of quartz, illite and carbonates with minor amounts of smectite, chlorite, feldspars and Fe oxides. The raw samples were then fired at temperatures of between 800 and 1050°C. The XRD data show that increases in firing temperature result in dehydroxylation of clay minerals, carbonate decomposition and the formation of Ca-bearing silicates (e.g. gehlenite, wollastonite, pyroxenes and anorthite). The sizes of the Ca-silicate crystals make the use of the SEM inappropriate since they lie below the resolution threshold. However, TEM/AEM do provide the required textural and compositional characterization, revealing that there is a broad range of pyroxene compositions, some of which resemble fassaite, and that Ca/Mg ratios increase with temperature. The TEM also shows significant dehydroxylation and vitrification of the clay-rich matrix at T of ~800°C. Observed mineralogical and textural changes probably occurred in a system with a local disequilibrium much like small-scale, high-temperature metamorphic reactions (i.e. pyrometamorphism). The importance of these results is that they enable the selection of more appropriate raw clay composition and firing dynamics (temperature, firing duration and cooling rate) for both the brickmaking industry and brick conservation in the field of cultural heritage.
Modification of kaolinite by controlled hydrothermal deuteration – a DRIFT spectroscopic study
Authors: Ming Hui 
Published: October 2004

AbstractKaolinites were modified by controlled hydrothermal deuteration. Both infrared and near infrared vibration spectra of deuterated kaolinite were investigated by Diffuse Reflectance Infrared Fourier Transform spectroscopy. The stretching vibrations (v) of deuteroxyl groups of the kaolinite were observed at 2726, 2709, 2697 and 2667 cm-1, respectively. The overtone bands (2n) of the deuteroxyl groups were visible in NIR regions at 5454, 5419, 5388 and 5342 cm-1, respectively. The lattice vibrations of the kaolinite taking part in deuteration included 937, 915, 792, 751 and 690 cm-1which are assigned to hydroxyl group-related deformation or translation-vibration mode. The hydroxyl band at 3435 cm-1with its deuteroxyl band at 2542 cm-1resulted from unevenly distributed structural defects, either due to the isomorphous substitution of foreign cations or the imperfections of the kaolinite lattice structure.
The platelet glycoprotein Ib–von Willebrand factor interaction activates the collagen receptor α2β1 to bind collagen: activation-dependent conformational change of the α2-I domain
Authors: Cruz Miguel A. , Chen Junmei , Whitelock Jody L. , Morales Liza D. , López José A. 
Published: October 2004

AbstractIntegrin α2β1 (glycoprotein [GP] Ia/IIa) is a major platelet receptor for collagen, containing its collagen-binding site within the α2 I domain. α2β1 changes conformation upon platelet activation, increasing its affinity for collagen. We observed that 2 antibodies known to bind within the α2I domain, 12F1 and 6F1, bound preferentially to adenosine diphosphate (ADP)–activated platelets. Interestingly, when whole blood was perfused over a surface coated with either 12F1 or 6F1, only 6F1 supported the adhesion of unstimulated platelets. To test whether the interaction of GP Ib with von Willebrand factor (VWF) directly activates α2β1, we used 12F1 as a probe of integrin activation. We perfused blood over a surface coated with a mixture of VWF-A1 domain (a GP Ib ligand) and 12F1 or VWF-A1 and mouse immunoglobulin G (IgG). Platelets rolled and did not attach stably on the A1/IgG surface, but they firmly bound and covered the A1/12F1 surface. We corroborated that 12F1 binds an active conformation of the I domain by showing that it binds with higher affinity to a gain-of-function mutant than to either wild-type I domain or a loss-of-function mutant. These results strongly suggest that the interaction of platelet GP Ib with VWF mediates the activation of α2β1, increasing its affinity for collagen.
Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells
Authors: Berger Carole L. , Tigelaar Robert , Cohen Justine , Mariwalla Kavita , Trinh Jennifer , Wang Nianci , Edelson Richard L. 
Published: October 2004

AbstractStudies in an in vitro model of cutaneous T-cell lymphoma (CTCL) demonstrated that CTCL cell proliferation is stimulated by direct contact with autologous, immature dendritic cells (DCs), suggesting that CD4+ CTCL cell division is driven by antigens presented by DC major histocompatibility complex (MHC) class 2. We now report that the T-cell receptor (TCR) of the CD4+ CTCL cells is triggered after interaction with DCs loaded with apoptotic CTCL cells, as shown by reduced membrane expression of CD3 and the TCR, up-regulation of cytotoxic T lymphocyte antigen-4 (CTLA-4), and calcium mobilization. CTCL cells adopt a T-regulatory (Treg) phenotype expressing CD25/CTLA-4 and FoxP3 and secreting interleukin-10 (IL-10) and transforming growth factor-β (TGF-β). Treg CTCL cells suppress normal T-cell antigen-driven secretion of IL-2 and interferon-γ (IFN-γ). Blocking DC MHC class 2 expression or transport inhibited CTCL cell adoption of a Treg phenotype. Allogeneic CTCL cells or normal CD4 T cells served as sources of apoptotic material for CTCL cell conversion to a Treg phenotype. Conversion of CTCL cells to Treg cells may explain the anergic, immunosuppressive nature of the malignancy. (Blood. 2005;105:1640-1647)
Combining gene expression data from different generations of oligonucleotide arrays
Authors: Hwang Kyu-Baek , Kong Sek Won , Greenberg Steve A , Park Peter J 
Published: October 2004

Abstract
Background
One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public repositories. Through a comparative analysis on a variety of datasets, a more comprehensive view of the underlying mechanism or structure can be obtained. However, as we discover in this work, continual changes in genomic sequence annotations and probe design criteria make it difficult to compare gene expression data even from different generations of the same microarray platform.

Results
We first describe the extent of discordance between the results derived from two generations of Affymetrix oligonucleotide arrays, as revealed in cluster analysis and in identification of differentially expressed genes. We then propose a method for increasing comparability. The dataset we use consists of a set of 14 human muscle biopsy samples from patients with inflammatory myopathies that were hybridized on both HG-U95Av2 and HG-U133A human arrays. We find that the use of the probe set matching table for comparative analysis provided by Affymetrix produces better results than matching by UniGene or LocusLink identifiers but still remains inadequate. Rescaling of expression values for each gene across samples and data filtering by expression values enhance comparability but only for few specific analyses. As a generic method for improving comparability, we select a subset of probes with overlapping sequence segments in the two array types and recalculate expression values based only on the selected probes. We show that this filtering of probes significantly improves the comparability while retaining a sufficient number of probe sets for further analysis.

Conclusions
Compatibility between high-density oligonucleotide arrays is significantly affected by probe-level sequence information. With a careful filtering of the probes based on their sequence overlaps, data from different generations of microarrays can be combined more effectively.
Reuse of imputed data in microarray analysis increases imputation efficiency
Authors: Kim Ki-Yeol , Kim Byoung-Jin , Yi Gwan-Su 
Published: October 2004

Abstract
Background
The imputation of missing values is necessary for the efficient use of DNA microarray data, because many clustering algorithms and some statistical analysis require a complete data set. A few imputation methods for DNA microarray data have been introduced, but the efficiency of the methods was low and the validity of imputed values in these methods had not been fully checked.

Results
We developed a new cluster-based imputation method called sequential K-nearest neighbor (SKNN) method. This imputes the missing values sequentially from the gene having least missing values, and uses the imputed values for the later imputation. Although it uses the imputed values, the efficiency of this new method is greatly improved in its accuracy and computational complexity over the conventional KNN-based method and other methods based on maximum likelihood estimation. The performance of SKNN was in particular higher than other imputation methods for the data with high missing rates and large number of experiments.
Application of Expectation Maximization (EM) to the SKNN method improved the accuracy, but increased computational time proportional to the number of iterations. The Multiple Imputation (MI) method, which is well known but not applied previously to microarray data, showed a similarly high accuracy as the SKNN method, with slightly higher dependency on the types of data sets.

Conclusions
Sequential reuse of imputed data in KNN-based imputation greatly increases the efficiency of imputation. The SKNN method should be practically useful to save the data of some microarray experiments which have high amounts of missing entries. The SKNN method generates reliable imputed values which can be used for further cluster-based analysis of microarray data.
Implications for domain fusion protein-protein interactions based on structural information
Authors: Chia Jer-Ming , Kolatkar Prasanna R 
Published: October 2004

Abstract
Background
Several in silico methods exist that were developed to predict protein interactions from the copious amount of genomic and proteomic data. One of these methods is Domain Fusion, which has proven to be effective in predicting functional links between proteins.

Results
Analyzing the structures of multi-domain single-chain peptides, we found that domain pairs located less than 30 residues apart on a chain are almost certain to share a physical interface. The majority of these interactions are also conserved across separate chains. We make use of this observation to improve domain fusion based protein interaction predictions, and demonstrate this by implementing it on a set of Saccharomyces cerevisiae proteins.

Conclusion
We show that existing structural data supports the domain fusion hypothesis. Empirical information from structural data also enables us to refine and assess domain fusion based protein interaction predictions. These interactions can then be integrated with downstream biochemical and genetic assays to generate more reliable protein interaction data sets.
Real-time PCR quantitation of glucocorticoid receptor alpha isoform
Authors: Melo Murilo R , Faria Cláudia DC , Melo Keli C , Rebouças Nancy A , Longui Carlos A 
Published: October 2004

Abstract
Background
The expression of glucocorticoid-receptor (GR) seems to be a key mechanism in the regulation of glucocorticoid (GC) sensitivity and is potentially involved in cases of GC resistance or hypersensitivity. The aim of this study is to describe a method for quantitation of GR alpha isoform (GRα) expression using real-time PCR (qrt-PCR) with analytical capabilities to monitor patients, offering standard-curve reproducibility as well as intra- and inter-assay precision.

Results
Standard-curves were constructed by employing standardized Jurkat cell culture procedures, both for GRα and BCR (breakpoint cluster region), as a normalizing gene. We evaluated standard-curves using five different sets of cell culture passages, RNA extraction, reverse transcription, and qrt-PCR quantification. Intra-assay precision was evaluated using 12 replicates of each gene, for 2 patients, in a single experiment. Inter-assay precision was evaluated on 8 experiments, using duplicate tests of each gene for two patients. Standard-curves were reproducible, with CV (coefficient of variation) of less than 11%, and Pearson correlation coefficients above 0,990 for most comparisons. Intra-assay and inter-assay were 2% and 7%, respectively.

Conclusion
This is the first method for quantitation of GRα expression with technical characteristics that permit patient monitoring, in a fast, simple and robust way.
Development of the time course for processing conflict: an event-related potentials study with 4 year olds and adults
Authors: Rueda M Rosario , Posner Michael I , Rothbart Mary K , Davis-Stober Clintin P 
Published: October 2004

Abstract
Background
Tasks involving conflict are widely used to study executive attention. In the flanker task, a target stimulus is surrounded by distracting information that can be congruent or incongruent with the correct response. Developmental differences in the time course of brain activations involved in conflict processing were examined for 22 four year old children and 18 adults. Subjects performed a child-friendly flanker task while their brain activity was registered using a high-density electroencephalography system.

Results
General differences were found in the amplitude and time course of event-related potentials (ERPs) between children and adults that are consistent with their differences in reaction time. In addition, the congruency of flankers affected both the amplitude and latency of some of the ERP components. These effects were delayed and sustained for longer periods of time in the children compared to the adults.

Conclusions
These differences constitute neural correlates of children's greater difficulty in monitoring and resolving conflict in this and similar tasks.