bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute kidney injury after pegylated granulocyte colony-stimulating factor therapy
Authors: Imataki Osamu , Yoshida Shunsuke , Hashimoto Shin-ichiro , Uemura Makiko 
Published: December 2023

Abstract
Pegylated granulocyte colony-stimulating factor (peg-G-CSF) is a safe long-acting form of G-CSF to improve chemotherapy-induced neutropenia. However, hyper response of neutropenia can be induced soon after an administration of peg-G-CSF. Neutrophil response is sometimes associated to fever, bone pain, and headache, however, this drug is generally safe and well-tolerated in cancer patients. Acute renal failure is rare adverse event of peg-G-CSF. We observed severe cell lysis resulted in acute renal failure in a combination use of peg-G-CSF and dexamethasone.
Exploration of the molecular characteristics and potential clinical significance of shared immune-related genes between preterm preeclampsia and term preeclampsia
Authors: Huang Zhengrui , Sun Lu , Gao Yudie , Shi Meiting , Zhang Ping , Ding Yuzhen , Wang Jian , Wei Jiachun , Yang Xiuli , Li Ruiman 
Published: December 2023

Abstract

Background
Preeclampsia is a severe obstetric disorder that significantly affects the maternal and neonatal peri-partum safety and long-term quality of life. However, there is limited research exploring the common mechanisms and potential clinical significance between early-onset preeclampsia and full-term preeclampsia from an immunological perspective.
Methods
In this study, data analysis was conducted. Initially, immune-related co-expressed genes involving both subtypes of preeclampsia were identified through Weighted Gene Co-expression Network Analysis (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were further employed to investigate the shared pathways regulated by immune-related genes. Binary logistic regression identified co-expressed genes with diagnostic value for preeclampsia, and a diagnostic model was constructed. Gene Set Enrichment Analysis (GSEA) predicted the potential biological functions of the selected genes. Lasso and Cox regression analyses identified genes closely associated with gestational duration, and a risk score model was established. A 4-gene feature, immune-related gene model for predicting the risk of preterm birth in preeclamptic pregnant women, was developed and validated through qPCR experiments. Immune cell infiltration analysis determined differences in immune cell infiltration between the two subtypes of preeclampsia.
Results
This study identified 4 immune-related co-expressed genes (CXCR6, PIK3CB, IL1RAP, and OSMR). Additionally, diagnostic and preterm birth risk prediction models for preeclampsia were constructed based on these genes. GSEA analysis suggested the involvement of these genes in the regulation of galactose metabolism, notch signaling pathway, and RIG-I like receptor signaling pathway. Immune pathway analysis indicated that the activation of T cell co-inhibition could be a potential intervention target for immunotherapy in early-onset preeclampsia.
Conclusion
Our study provides promising insights into immunotherapy and mechanistic research for preeclampsia, discovering novel diagnostic and intervention biomarkers, and offering personalized diagnostic tools for preeclampsia.
Coral reef fish biomass and nutrient availability losses from thermal stress
Authors: Zamborain-Mason Jessica , Eurich Jacob , Viana Daniel , Mellin Camille , Pinsky Malin , Hooidonk Ruben van , Golden Christopher 
Published: December 2023

Abstract
Thermal stress driven by climate change is a major threat to tropical coral reef ecosystems1, with marine heatwaves expected to increase in frequency and intensity throughout the century. While corals are most often the focus of impacts2,3, thermal associated changes on reef fishes may lead to important flow-on effects for the nutrients available for people dependent on reef fisheries for food4. Here, we examine the cumulative impacts of thermal stress on reef fish assemblages between 1996 and 2020 to project the potential impacts of different climate change scenarios on reef fish biomass and associated nutrients available to human populations. We show that reefs that have experienced greater thermal stress in the past tend to have less reef fish biomass across all trophic guilds, and reduced nutrient availability across all nutrients. Applying such association to future thermal stress projections implies a continued decline in reef fish biomass and nutrient provision throughout the century. However, spatial variability in thermal stress projections pinpoints the locations and reef-based food systems that could (i) suffer the largest biomass and nutrient availability losses, and (ii) benefit the most from implementen climate mitigation strategies. Overall, our study provides empirical evidence that both climate change mitigation and adaptation are needed to bolster reef fish assemblages and associated tropical nutrition security.
Different anatomic patterns of the indirect tendon of the rectus femoris
Authors: Meca Sandra Mechó , Posse Iñigo Iriarte , Ortega Raquel Lisbona , Pérez-Andrés Ricard , Grivé Ricard Pruna , Rodríguez-Baeza Alfonso 
Published: December 2023

Abstract
Purpose-The rectus femoris (RF) forms the anterior portion of the quadriceps muscle group. It has a proximal tendinous complex (PTC), which is constituted by a direct tendon (DT), an indirect tendon (IT), and a variable third head. DT and IT converge into a common tendon (CT). The purposes of this study are to add anatomical knowledge about the PTC and describe 3 anatomical variants of the IT and, on their basis, to categorize 4 different morphological patterns, through the analysis of 48 cadaveric lower limbs. Method-In this study, 48 hemipelvis from bodies donated to the Universitat Autònoma de Barcelona have been dissected to examine the PTC of the RF. Results-The following anatomical variants were described: inferior aponeurotic expansion in 23/48 cases (47.9%); superior aponeurotic expansion in 21/48 cases (43.7%); and abnormal origin of the myotendinous junction of the RF in the free portion of the IT in 19/48 cases (39.6%). Based on two of these variants, the following morphological patterns were defined: standard IT (19/48 cases, 39.6%), superior and inferior complex IT (15/48 cases, 31.2%), inferior complex IT (8/48 cases, 16.7%), and superior complex IT (6/48 cases, 12.5%). Conclusion-We can categorize 4 different IT morphological patterns, three of them are complex and we suggest that these complex patterns can cause an increased IT stiffness and so can be considered non-modifiable risk factors for RF injuries. Therefore, it would be convenient to identify complex patterns and perform injury prevention actions through specific physical preparation programs.
Trehalose-6-phosphate phosphatase (TPP) participates in cold acclimatization of Actinidia arguta depending on the ethylene signal transduction pathway
Authors: Eh Tong-Ju , Lei Pei , Phyon Jong-Min , Kim Hyon-Il , Xiao Yue , Eh Nam-Myong , Ma Le , Li Jianxin , Jin Guangze , Meng Fanjuan 
Published: December 2023

Abstract
Actinidia arguta (kiwiberry) is a perennial deciduous vine that has a very strong overwintering ability. We speculated that trehalose metabolism, which plays a pivotal role in the stress tolerance of plants, may be involved in the cold acclimatization of A. arguta. Transcriptome analysis showed that the expression of AaTPPA, encoding a trehalose-6-phosphate phosphatase (TPP), was upregulated in response to low temperature. AaTPPA expression levels were much higher in lateral buds, roots, and stem cambium than in leaves in autumn. In AaTPPA-overexpressing (OE) Arabidopsis thaliana, trehalose levels were 8 ~ 11 times higher than that of the wild type (WT) and showed different phenotypic characteristics from WT or overexpression lines of OtsB, the E. coli TPP gene. Surprisingly, AaTPPA-OE A. thaliana had significantly higher freezing tolerance than WT and OtsB-OE lines. Transient overexpression of AaTPPA in A. arguta leaves increased ROS scavenging capacity and the contents of soluble sugars and proline. AaERF64, an ethylene-responsive transcription factor, was induced by ethylene treatment, and bound to the GCC-box of the AaTPPA promoter to activate its expression. AaTPPA expression was also induced by abscisic acid (ABA). Overall, the temperature decrease in autumn induces AaERF64 expression through the ethylene signal transduction pathway, which in turn upregulates AaTPPA expression, leading to the accumulation of osmotic protectants including soluble sugars and proline in the overwintering tissues of A. arguta.
Synergistic Interdecadal Effects of the North Pacific and North Atlantic SST on Precipitation over eastern China as revealed in the ECHAM5 simulations
Authors: Wu Minmin , Zhang Rong-Hua , Zhi Hai , Hu Junya 
Published: December 2023

Abstract

In this investigation, we examine the individual and synergistic effects of sea surface temperature (SST) in the North Pacific and North Atlantic on precipitation interdecadal variations over eastern China using the Multi-Taper Method-Singular Value Decomposition (MTM-SVD) method based on the European Center Hamburg model version 5 (ECHAM5) simulations. Results reveal that the model adequately reproduces the quasi-periodic precipitation responses corresponding to interdecadal SST forcing in the North Pacific, North Atlantic and both regions. The Pacific Decadal Oscillation (PDO) is closely related to a meridional tri-polar precipitation pattern over eastern China. This precipitation pattern is attributed to the western Pacific subtropical high and surface pressure anomalies over northern East Asia, influenced by the joint effects of a mid-latitude wave train and SST anomalies in the central-western North Pacific. The North Atlantic basin-scale SST (NABS) correlates positively with precipitation over North China and negatively with precipitation over Southwest China. This precipitation pattern is affected by the westward shift of the atmospheric activity center over East Asia associated with the mid-latitude wave train across Eurasia. The combined SST forcing from the North Pacific and North Atlantic results in a meridional precipitation dipole pattern, and partially explains the precipitation interdecadal variation as observed. That is, as the PDO warm phase transitions to the NABS warm phase, rainbands experience an interdecadal northward shift from South China to North China. These results are pivotal for understanding how interdecadal SST forcing in the North Pacific and North Atlantic influences the precipitation distribution over China, thereby contributing to improvements in interdecadal climate prediction.
Ovicidal, larvicidal and adulticidal activity of black pepper (Piper nigrum L.) essential oil and tea tree oil (Melaleuca alternifolia) against Haemonchus contortus
Authors: Mohamed Hend Ibrahim , Arafa Waleed M. , Ahmed Osama M. , El-Dakhly Khaled Mohamed 
Published: December 2023

Abstract

Haemonchosis is a helminthic disease affecting ruminants worldwide. The anthelminthic resistance has become raised. Medicinal plants are safely used as synthetic anthelmintics. Currently, the efficacy of black pepper essential oil (BPO) and tea tree oil (TTO) were in vitro evaluated against H. contortus adults, eggs and larvae at concentrations of 1.25, 2.5 and 5 mg/ml in addition to the commercially used albendazole at a concentration of 10 µg/ml. Oils were used in both normal and nanoparticles-loaded forms. Oxidative stress enzymes of worms were estimated. Scanning electron microscopy (SEM) for treated worms was done. Both normal and nanoemulsion forms of both BPO and TTO stopped the adult motility [BPO 2.5 hours (hrs), NBPO 1.5hrs, TTO 3 hrs, NTTO 1.5 hrs] and induced a marked decrease in the oviposition. Post treatment, the egg development and hatching were significantly (P ≤ 0.05) reduced. The damage of the egg shell, embryonal cessation and destruction of larvae occurred. Noticeable elevated antioxidant enzymes (catalase CAT, glutathione transferase GST and glutathione GSH) were found, while oxidative enzymes (lipid peroxidation LPO and nitric oxide synthase NOS) deceased. Scanning electron microscopy (SEM) for both oil-treated worms revealed anterior ends damage and several cuts associated with cuticular pores. The use of albendazole induced more or less anthelmintic activities, enzymatic activities with less morphological alterations of adults revealed by SEM. This study proved the marked anthelmintic potency of the BPO and TTO and their nanoemulsion forms against H. contortus rather than the widely used anthelminthic drugs.
Association between Urine Parabens and Liver Function in US Adolescents: A cross-sectional study based on NHANES 2007–2016
Authors: Li Linfei , Hu Gunchu , Luo Xiong , Wei Zuxing , Yu Zhuowen , He Jun 
Published: December 2023

Abstract
Paraben esters are commonly used as preservatives in cosmetics, personal hygiene products, food and drugs. However, there is a lack of evidence regarding the impact of exposure to Paraben esters on adolescent liver function. We analyzed data from the 2007–2016 National Health and Nutrition Examination Survey (NHANES). Finally, 1845 adolescents aged 12 to 19 were selected as a random sample. Analysis of the Effect of Urinary Parabens on Liver Function Indexes Using Weighted Linear Regression.Then, we applied the weighted quantile sum (WQS) analysis and the Bayesian kernel machine regression (BKMR) to examine the associations between parabens and liver function indicators. Based on the results from three different models, four parabens and their total were negatively associated with ALB and ALP, and positively associated with TBIL. Moreover, among the parabens, butyl paraben and propyl paraben had the highest weights.Overall, our results indicate that parabens are significantly but weakly associated with changes in liver function in US adolescents. Further research is needed to explore these relationships.
Isolation of Streptomyces inhibiting multiple-phytopathogenic fungi and characterization of lucensomycin biosynthetic gene cluster
Authors: Park Heung-Soon , Kang Seung-Hoon , Choi Si-Sun , Kim Eung-Soo 
Published: December 2023

Abstract
Soil microorganisms with diverse bioactive compounds such as Streptomyces are appreciated as valuable resources for the discovery of eco-friendly fungicides. This study isolated a novel Streptomyces from soil samples collected in the organic green tea fields in South Korea. The isolation process involved antifungal activity screening around 2400 culture extracts, revealing a strain designated as S. collinus Inha504 with remarkable antifungal activity against diverse phytopathogenic fungi. S. collinus Inha504 inhibited seven phytopathogenic fungi, including Fusarium oxysporum and Aspergillus niger, in bioassays and showed a control effect against F. oxysporum infected red pepper, strawberry, and tomato in the in vivo pot test. Genome mining of S. collinus Inha504 revealed the presence of the biosynthetic gene cluster (BGC) in the chromosome encoding a polyene macrolide which is highly homologous to the lucensomycin (LCM), a compound known for effective in crop disease control. Through genetic confirmation and bioassays, the antifungal activity of S. collinus Inha504 was attributed to the presence of LCM BGC in the chromosome. These results could serve as an effective strategy to select novel Streptomyces strains with valuable biological activity through bioassay-based screening and identify biosynthetic gene clusters responsible for the metabolites using genome mining approach.
Comparing Symptom Clusters in Cancer Survivors by Cancer Diagnosis: A Latent Class Profile Analysis
Authors: Lee Lena J. , Han Claire J. , Saligan Leorey , Wallen Gwenyth R. 
Published: December 2023

Abstract

Purpose: Research on symptom clusters in oncology is progressing, but knowledge gaps remain. One question is whether the number and types of Symptom Subgroups differ based on cancer diagnosis. However, no research has compared Symptom Subgroups in heterogeneous populations based on cancer diagnosis. The purpose of this study was to: (1) identify the clustering of four highly prevalent symptoms (pain, fatigue, sleep disturbance, and depression), and (2) compare symptom clusters across the seven populations of cancer survivors (prostate, non-small cell lung, non-Hodgkin’s lymphoma, breast, uterine, cervical, and colorectal cancer).
Methods: This study is a cross-sectional secondary analysis of data obtained from the My-Health study in partnership with four Surveillance, Epidemiology, and End Results (SEER) cancer registries located in California (two), Louisiana, and New Jersey. The sample included 4,762 cancer survivors 6-13 months following diagnosis of one of the seven cancer types mentioned. Latent class profile analysis was used.
Results: Subjects were primarily young (59% age 21-64 years), Caucasian (41%), married/cohabitating (58%) and unemployed (55%). The number of symptom subgroups varied across these seven cancer populations: (1) four-class solution in prostate, lung, non-Hodgkin’s lymphoma, and breast cancer survivors; (2) three-class solution in uterine and cervical cancer survivors; and (3) two-class solution in colorectal cancer survivors.
Conclusion: Identifying symptom subgroups by cancer diagnosis has the potential to develop innovative and effective targeted interventions in cancer survivors. Further research is needed to establish extensive knowledge in symptom clustering between treatment regimens, and short-term and long-term cancer survivors.
Insights into the seismogenic structures of the arc-continent convergent plate boundary in eastern Taiwan
Authors: Chen Wen-Shan , Wu Y.M. , Yeh P.Y. , Lai Y.X. , Ke S.S. , Ke M.C. , Yang C.Y. 
Published: December 2023

Abstract

The doubly vergent orogen in Taiwan is a relatively young and active arc-continent collision caused by the convergence of Eurasian and Philippine Sea Plates occurring along a complicated seismogenic plate boundary. This study aims to investigate the evolutionary and tectonic features of the retro-wedge, a region contributing to the uplifting and shortening of the Taiwan orogen. Through the utilization of seismic tomographic image and relocated seismicity, we identify three potential seismogenic structures along the convergent plate boundary: the Longitudinal Valley Fault, the Ludao–Lanyu Fault, and the Central Range Fault. A significant discovery in our investigation of a west-dipping backthrust of the Central Range Fault, extending from the north Hualien city to the southeastern offshore at a distance of 300 km. The fault is responsible for the formation of a crustal-scale pop-up structure, contributing to the development of a double vergent orogenic wedge in the retro-wedge. The genesis of the basement-involved backthrust is attributed to the indentation of the exhumed forearc mantle wedge and remnant forearc crust into the Backbone Range during collision. Consequently, the plate boundary exhibits two opposite vergent thrust systems of the Longitudinal Valley Fault–Ludao–Lanyu Fault and Central Range Fault, which evolved during different stages of collision-incipient and mature following the closure of the forearc basin of the North Luzon Trough and Longitudinal Valley, respectively. These findings contribute novel insights into the tectonic framework of the convergent zone and provide valuable constraints for geodynamic models of arc-continent collision
Underground karst development characteristics and their influence on exploitation of karst groundwater in Guilin city， Southwest China
Authors: Pu Zhenggong , Huang Qibo , Liao Hong-Wei , Wu Hua-ying , Jiao You-Jun , Luo Fei , Li Teng-Fang , Zhao Guang-Shuai , Chang-pei Zou 
Published: December 2023

Abstract
Exploitation and utilization of karst groundwater is an effective way of solving the imbalance between supply and demand of water resources in Guilin City, southwestern China. In this study, we carried out a systematic investigation of the underground karst developmental characteristics and their influence on the migration and occurrence of karst groundwater in Guilin city. The results show that the thick limestone formation of D3r is the most ideal aquifer because it has the highest karst development and the most abundant karst groundwater. The main karst development zone is above 90 m a.s.l., and it accounts for 88.5 % of the karst caves, 11.5 % karst caves are located in the weak karst developed zone of 40-90 m a.s.l, and below 40 m a.s.l., the karst is not developed. Thus, the borehole depth for groundwater extraction is suggested to be approximately 100-120 m owing to the ground-surface elevation of Guilin city being 140-160 m a.s.l. The zone above 120 m a.s.l. is not optimal for karst groundwater exploitation because of its high karst cave filling rate (82.89 %) and low water-filling cavity ratio (16.95-30.08 %), in which the karst groundwater easily connects with surface water therefore an increase of possibility of collapse when extracting groundwater. The zone between 120-90 m a.s.l. could be more optimal for groundwater extraction due to its medium scale of karst caves, relatively low karst cave filling rate (62.07 %), and high water-filling cavity rate (30.43 %-62.10 %) relatively. Meanwhile, a favorable groundwater exploitation and utilization region is located in the eastern study area, which has the highest underground karst development, with the highest percentage of boreholes encountering caverns (80.21 %), linear karst rates (8.58 %), and the lowest karst cave filling rate (65.61 %). This study provides a scientific basis for the exploitation of karst groundwater and construction of a backup emergency water sources for Guilin City.
Measuring Cultural Specificity of Professional Vocabulary
Authors: Leon Volha , Piniuta Iryna , Karachun Tatyana , Kryshtop Inessa 
Published: December 2023

Abstract

This paper explains some reasons for communication breakdown in professional discourse in cross-cultural and intercultural communication, which lie in the difference of what is associated with a particular word of the same language in different cultures. To avoid misinterpretation, misunderstanding and misconception in the professional communication in English between teachers representing different communicative cultures, the authors suggest a quantitative semantic tool to measure the risk of misinterpretation of professional vocabulary. The research aims to determine the degrees of semantic in-equivalence of pedagogical culture-specific vocabulary which is used in professional discourse practices by American and Belarusian teachers in their interactions in English, and identify linguistic and extralinguistic factors that create misunderstandings. To determine the degree of specificity of professional vocabulary, it was suggested to apply cultural specificity index, which was developed by the authors specifically to achieve the measurable objectives of the given research and to facilitate further studies in the highlighted area of concern. The semantic analysis of respondents’ subjective definitions of 26 vocabulary items resulted in their classification and clarification in the context of cross-cultural understanding.