bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility-sparing uterine displacement for pelvic malignancies: surgical options and radiotherapy dosimetry on a human cadaver
Authors: Pavone Matteo , Waeldin Laure , Seeliger Barbara , Bizzarri Nicolò , Mutter Didier , Jarnet Delphine , Forgione Antonello , Georges Noel , Akladios Cherif , Scambia Giovanni , Marescaux Jacques , Lecointre Lise , Querleu Denis 
Published: January 2024

Abstract
Background
Radio(chemo)therapy is often required in pelvic malignancies (cancer of the anus, rectum, cervix). Direct irradiation adversely affects ovarian and endometrial function, compromising the fertility of women. While ovarian transposition is an established method to move the ovaries away from the radiation field, surgical procedures to displace the uterus are investigational. This study demonstrates the surgical options for uterine displacement in relation to the radiation dose received.
Methods
The uterine displacement techniques were carried out sequentially in a human female cadaver to demonstrate each procedure step by step and assess the uterine positions with dosimetric CT scans in a hybrid operating room. Two treatment plans (anal and rectal cancer) were simulated on each of the four dosimetric scans (1. anatomical position, 2. uterine suspension of the round ligaments to the abdominal wall 3. ventrofixation of the uterine fundus at the umbilical level, 4. uterine transposition). Treatments were planned on Eclipse® System (Varian Medical Systems®,USA) using Volumetric Modulated Arc Therapy. Data about maximum (Dmax) and mean (Dmean) radiation dose received and the volume receiving 14Gy (V14Gy) were collected.
Results
All procedures were completed without technical complications. In the rectal cancer simulation with delivery of 50Gy to the tumor, Dmax, Dmean and V14Gy to the uterus were respectively 52,8Gy, 34,3Gy and 30,5cc (1), 31,8Gy, 20,2Gy and 22.0cc (2), 24,4Gy, 6,8Gy and 5,5cc (3), 1,8Gy, 0,6Gy and 0,0cc (4). For anal cancer, delivering 64Gy to the tumor respectively 46,7Gy, 34,8Gy and 31,3cc (1), 34,3Gy, 20,0Gy and 21,5cc (2), 21,8Gy, 5,9Gy and 2,6cc (3), 1,4Gy, 0,7Gy and 0,0cc (4).
Conclusions
The feasibility of several uterine displacement procedures was safely demonstrated. Increasing distance to the radiation field requires more complex surgical interventions to minimize radiation exposure. Surgical strategy needs to be tailored to the multidisciplinary treatment plan, and uterine transposition is the most technically complex with the least dose received.
Crecimiento de ejemplares postmetamórficos y juveniles de Concholepas concholepas (BRUGUIERE) en condiciones de laboratorio. Efecto de densidad, dieta y temperatura,
Authors: Méndez Marcos A. , Cancino Juan M. 
Published: January 2024

Se estudiaron los efectos de la densidad (número de ejemplares por acuario), del volumen de agua del recipiente, de la dieta y la temperatura en el crecimiento de ejemplares postmetamórficos y juveniles de Concholepas concholepas en condiciones de laboratorio. El efecto de la densidad fue estudiado entre marzo y junio de 1990 en 80 juveniles entre 6 y 12 mm de longitud peristomal, mantenidos a tres densidades (0,005; 0,010 y 0,020 "locos" cm'2). El efecto del volumen fue estudiado utilizando 20 animales entre 5 y 9,8 mm de longitud peristomal, mantenidos individualmente en recipientes de distinto tamaño (0,3 a 2,0 1). El efecto de la dieta en el crecimiento fue estudiado en 35 ejemplares de C. concholepas entre 6 y 12 mm de longitud peristomal alimentados con dietas monoespecíficas y mixtas de tres tipos de presas (Semimytilus algosus, Perumytilus purpuratus y Balanus laevis). El efecto de la temperatura en el crecimiento y en el balance energético fue investigado usando ejemplares recién metamorfoseados obtenidos a partir de larvas competentes recolectadas del plancton yen individuos postmetamórficos (2 a 3 mm) recolectados del intermareal. Individuos de cada grupo fueron mantenidos por 22 semanas a 10°C y a 20°C. Se evaluó el consumo de presas, las tasas metabólicas aclimatadas, la eficiencia de conversión bruta (K.1) y el crecimiento a ambas temperaturas.
Photodynamic Therapy as a Desirable Approach in the Treatment of
Colorectal Cancer, with Special Focus on Photodynamic Nanotherapeutics
in Immunotherapy
Authors: Mollazadeh Samaneh , Mehrabadi Shima , Hassanian Seyed Mahdi , Ghayour-Mobarhan Majid , Ferns Gordon A , Khazaei Majid , Avan Amir 
Published: January 2024

Abstract:
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide;
however, there is not a convincing treatment for this disease. Limitations of conventional
CRC therapies force scientists to develop novel treatment concepts for both
primary care alongside adjuvant therapy. Photodynamic therapy (PDT) has been introduced
as a promising therapeutic procedure for CRC mediated through theranostic principle
in which special dyes, photosensitizers (PSs), are excited by near-infrared (NIR)
and visible light. Recent studies showed that PDT has synergistic effects in combination
with chemotherapy or immunotherapy in the treatment of CRC patients. Of note, nanoformulation
of PS or immunotherapeutic agents could augment the PDT effectiveness.
In this review, we summarize PDT application in CRC management with a special focus
on the nanoparticles-based delivery system from the perspective of targeting deeper
CRC and increased PDT efficiency, which could provide a desirable approach for clinical
translation.
Association between Postmenopausal Osteoporosis and IL-6、TNF-α: A
Systematic Review and A Meta-analysis
Authors: Huang Xudong , Ni Baihe , Li Qi , Liu Meichen , Zhao Minghua , Zhang Yanqi , Shi Xiaolin , Wang Weiguo 
Published: January 2024

Background:
Postmenopausal osteoporosis (PMOP) greatly increases the risk of bone
fracture in postmenopausal women, seriously affects the quality of life of patients, and is an important global public health problem. Persistent chronic systemic inflammation may be involved
in the change process of PMOP, and many cytokines, such as TNF-alpha and Interleukin-6, play
an important role in the inflammatory response. Therefore, This study takes commonly representative inflammatory factors as indicators to better determine their role in PMOP patients by
means of databases from multiple studies for use in Meta-analysis.

Method:
Systematic review of studies on the relationship between PMOP and markers of inflammation: interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Each effect size was
expressed with a 95% confidence interval (CI), and I2 quantified the heterogeneity. The final
results were aggregated and evaluated using random or fixed effects models.

Results:
Twenty-one original studies were identified. There were twenty studies involving IL-6
and eleven involving TNF-α. Overall, The levels of IL-6[MD=23.93, 95%CI (19.65, 28.21)] and
TNF-α[MD=2.9, 95%CI (2.37, 3.44)] were increased in PMOP patients compared with postmenopausal women without osteoporosis; The levels of IL-6[MD=42.4, 95%CI (38.62, 46.19)] and
TNF-α[MD=0.40, 95%CI (0.36, 0.44)] were significantly higher than those of premenopausal
healthy women

Conclusions:
The levels of inflammatory cytokines IL-6 and TNF-α were significantly increased
in PMOP patients compared with controls, suggesting that persistent chronic inflammatory reaction exists in PMOP patients, which may be an important cause of aggravated osteoporosis in
postmenopausal women. Therefore, the level of IL-6 and TNF-α indexes may be of great significance for the early prevention, diagnosis, treatment and prognosis assessment of PMOP.
SMAC Mimetics for the Treatment of Lung Carcinoma: Present
Development and Future Prospects
Authors: Pandey Ruchi , Bisht Priya , Wal Pranay , Murti Krishna , Ravichandiran V. , Kumar Nitesh 
Published: January 2024

Background:
Uncontrolled cell growth and proliferation, which originate from lung tissue
often lead to lung carcinoma and are more likely due to smoking as well as inhaled environmental
toxins. It is widely recognized that tumour cells evade the ability of natural programmed death
(apoptosis) and facilitates tumour progression and metastasis. Therefore investigating and targeting
the apoptosis pathway is being utilized as one of the best approaches for decades.

Objective:
This review describes the emergence of SMAC mimetic drugs as a treatment approach,
its possibilities to synergize the response along with current limitations as well as future perspective
therapy for lung cancer.

Method:
Articles were analysed using search engines and databases namely Pubmed and Scopus.

Result:
Under cancerous circumstances, the level of Inhibitor of Apoptosis Proteins (IAPs) gets elevated,
which suppresses the pathway of programmed cell death, plus supports the proliferation of
lung cancer. As it is a major apoptosis regulator, natural drugs that imitate the IAP antagonistic response
like SMAC mimetic agents/Diablo have been identified to trigger cell death. SMAC i.e. second
mitochondria activators of caspases is a molecule produced by mitochondria, stimulates apoptosis
by neutralizing/inhibiting IAP and prevents its potential responsible for the activation of caspases.
Various preclinical data have proven that these agents elicit the death of lung tumour cells.
Apart from inducing apoptosis, these also sensitize the cancer cells toward other effective anticancer
approaches like chemo, radio, or immunotherapies. There are many SMAC mimetic agents such as
birinapant, BV-6, LCL161, and JP 1201, which have been identified for diagnosis as well as treatment
purposes in lung cancer and are also under clinical investigation.

Conclusion:
SMAC mimetics acts in a restorative way in the prevention of lung cancer.
Molecular Docking of Phytomolecules of Grain Amaranth (Amaranthus hypochondriacus) with AKR1C3Protein Involved in Prostate Cancer in Human Beings
Authors: Pandey Dinesh , Bharti Manisha , Rana Anubhav , Prabhakaran Sharat , Chauhan Rashmi 
Published: January 2024

Abstract:
This study focuses on exploring how the bioactive compounds found in amaranth—
phytol, squalene, and α-tocopherol—could potentially offer medicinal benefits in the context of prostate
cancer. The investigation involves a docking study with AKRC13, an important target linked to
the control of prostate cancer, aiming to uncover their potential effects against this disease. Costeffective
and efficient cancer treatment options are crucial because of the high expenses associated
with current cancer therapies as well as their side effects. Amaranth (Amaranthus hypochondriacus)
is a pseudocereal crop abundant in squalene, α-tocopherol, and phytol, which shows promising foodbased
therapy for various diseases, including cancer. Prostate cancer has been a significant contributor
to mortality globally, but the introduction of relugolix has emerged as a crucial therapeutic intervention
in its treatment. Hence, this study was conducted to investigate the interactions between
grain amaranth bioactive compounds squalene, phytol, and α-tocopherol with AKRC13 protein utilizing
a molecular docking approach facilitated by Autodock Vina software. Research Collaboratory
for Structural Bioinformatics Protein Data Bank (RCSB-PDB) (http://www.rcsb.org/) was used for
retrieving the 3D crystal structure of the target protein, AKRC13 (PDB ID: 7c7f). The 3D structure
of bioactive compounds squalene, phytol, and α-tocopherol were retrieved from the PubChem database,
following which Open-Babel was used to change the format from .sdf to .pdb. Furthermore,
pharmacokinetics characteristics were also considered along with Lipinski’s rule of five using SwissADME
(http://www. Swiss adme.ch/index.php) and pkCSM (http://structure.bioc.cam.ac.uk/pkcsm),
indicating their potential as a drug candidate in the initial stage. The potential anticancer properties
of the ligands were predicted using PASS software. Following the completion of the docking study,
it became evident that α-tocopherol demonstrated the most significant binding energy, followed by
squalene and phytol, in comparison to the established drug, relugolix. This implies that the chosen
bioactive compounds might possess enzyme-inhibiting properties, indicating their potential for further
in vivo anticancer screening using model organisms. The findings serve as stepping stones for
advancing the potential use of the discussed bioactive compounds as a potential drug candidate for
prostate cancer.
Atomic Electrostatic Potential as a Descriptor of Aminolysis of Phenyl and
Thiophenyl Acetates and Hydrolysis of Acetanilides
Authors: Krylov Evgeny , Virzum Lyudmila , Gruzdev Matvey , Chervonova Ulyana 
Published: January 2024

Abstract:
Hydrolysis of acetanilides and aminolysis of phenyl and thiophenyl acetates are related
reactions since these are processes of nucleophilic substitution on the carbonyl carbon. Current views
of chemical reactivity based on the DFT theory rely upon reactivity indices that are descriptors of
both the reaction center and the molecule as a whole, and have not been applied to the given processes
before. One of such descriptors is an atomic electrostatic potential. The given parameter was calculated
by the DFT theory M06/6-311+G (non-specific solvation, MeCN, SMD, and full optimization)
for the structures of substituted phenyl acetates XPhO-C(O)Me, acetanilides XPhNHC(O)Me, thiophenyl
acetates ZPhSC(=O)Me, and benzyl amines XPhСH2NH2 (X, Z substituents). It has been
found that all relationships between the atomic electrostatic potential, the charge on the reaction center
in the Hirshfeld scheme, and logK are symbatic. Consequently, in all of the cases, the rate is determined
by the nucleophilic attack on the reaction center, with the activity/selectivity relationship
being observed. The fact that the reaction rate is limited by the nucleophilic attack of the reagent is
not inconsistent with the views of the reaction being concerted, since it is known that such reactions
may be quite concerted though not quite synchronous.
The Impact of the COVID-19 Pandemic on Women’s Health: A Review
Authors: Singh Deepika 
Published: January 2024

:
During any crisis, whether it is health, economic, or environmental, people are more
likely to experience stress, anxiety, and other psychological issues that jeopardize their general
well-being. The Coronavirus, or COVID-19, is considered a global pandemic that affects millions
of persons. Many people of different ages have significantly suffered from mental illness as a result
of COVID-19, especially women affected vulnerable. As per the report, the death rates of
men have doubled in comparison with women; this epidemic shows a bigger influence on the
health of women than men. Even quarantine impacts make the females afraid, bewildered, and
feel alone, which is terrible for them, as it also disturbs their health, such as pregnancy, sexual
life, postpartum depression, etc. This review article reveals the COVID-19 impact on the health of
women and finds a way to prevent and manage the health implications in women at various periods
throughout their lives.
Protective Effect of Statin Therapy in Ankylosing Spondylitis
Authors: Tavasolian Fataneh , Abdollahi Elham , Inman Robert D. , Sahebkar Amirhossein 
Published: January 2024

:
Ankylosing spondylitis (AS) is a complex autoimmune and auto-inflammatory disorder
characterized by a gradual onset that can progress to spinal ankylosis over time. This chronic condition
primarily affects the sacroiliac joints and the spine, often extending its influence to peripheral
joints and extra-articular organs, including the eyes AS is associated with significant disability, along
with comorbidities such as uveitis and inflammatory bowel disease. Moreover, individuals with AS
face an elevated risk of mortality due to cardiovascular disease (CVD). This paper explores the potential
benefits of statins, known for their anti-inflammatory and immunomodulatory effects, in mitigating
AS-related cardiovascular risk and their therapeutic effects on disease activity.
A Contemporary Review on the Critical Role of Nonsteroidal Anti-inflammatory
Agents in Colorectal Cancer Therapy
Authors: Zia Sarabi Parisa , Moradi Mohammad , Bagheri Malihe , Khalili Mohammad Reza , Moradifard Shahrzad , Jamialahmadi Tannaz , Ghasemi Faezeh , Sahebkar Amirhossein 
Published: January 2024

Abstract:
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are widely recognized as effective pain relievers and
function by inhibiting the cyclooxygenase enzyme (COXs). Moreover, they have been found to participate in
various cellular processes through different signaling pathways, such as WNT, MAPK, NF-KB, and
PI3K/AKT/mTOR. This makes them potential candidates for chemoprevention of several malignancies, particularly
colorectal cancer (CRC). However, the use of NSAIDs in cancer prevention and treatment is a complex
issue due to their adverse effects and gastrointestinal toxicity. Therefore, it is crucial to explore combination
therapies that can minimize side effects while maximizing synergistic effects with other agents and to evaluate
the success rate of such approaches in both pre-clinical and clinical studies. In this review, we aim to provide an
overview of the effects of NSAIDs in the prevention and treatment of CRC. We will focus on elucidating the
possible mechanisms of action of these drugs, the signaling pathways involved in CRC, and the potential synergistic
effects when combined with other therapeutic agents.
The Application of Kinesin Inhibitors in Medical Issues
Authors: Nejabat Mojgan , Hadizadeh Farzin , Sahebkar Amirhossein 
Published: January 2024

Abstract:
Kinesins are a group of motor proteins in charge of several crucial functions in the cell.
These proteins often bind to microtubules and perform their functions using the energy produced by
ATP hydrolysis. One function of mitotic kinesin, a subclass of kinesin that is expressed during cell
division at the mitotic phase, is to create the mitotic spindle. Uncontrolled cell growth is one trait of
cancerous cells. Traditional anticancer medications still used in clinics include taxanes (paclitaxel)
and vinca alkaloids (vincristine, vinblastine), which interfere with microtubule dynamics. However,
because non-dividing cells like post-mitotic neurons contain microtubules, unwanted side effects
like peripheral neuropathy are frequently found in patients taking these medications. More than ten
members of the mitotic kinesin family play distinct or complementary roles during mitosis. The mitotic
kinesin family's KSP, or Eg5, is regarded as its most dramatic target protein. The current work
systematically reviews the use of kinesin inhibitors in the medical field. The challenges of KSP and
the practical solutions are also examined, and the outcomes of the previous works are reported. The
significant gaps and shortcomings of the related works are also highlighted, which can be an onset
topic for future works.
Feasibility Study on Menstrual Cycles With Fitbit Device (FEMFIT): Prospective Observational Cohort Study
Authors: Lang Anna-Lena , Bruhn Rosa-Lotta , Fehling Maya , Heidenreich Anouk , Reisdorf Jonathan , Khanyaree Ifrah , Henningsen Maike , Remschmidt Cornelius 
Published: January 2024

Background
Despite its importance to women’s reproductive health and its impact on women’s daily lives, the menstrual cycle, its regulation, and its impact on health remain poorly understood. As conventional clinical trials rely on infrequent in-person assessments, digital studies with wearable devices enable the collection of longitudinal subjective and objective measures.

Objective
The study aims to explore the technical feasibility of collecting combined wearable and digital questionnaire data and its potential for gaining biological insights into the menstrual cycle.

Methods
This prospective observational cohort study was conducted online over 12 weeks. A total of 42 cisgender women were recruited by their local gynecologist in Berlin, Germany, and given a Fitbit Inspire 2 device and access to a study app with digital questionnaires. Statistical analysis included descriptive statistics on user behavior and retention, as well as a comparative analysis of symptoms from the digital questionnaires with metrics from the sensor devices at different phases of the menstrual cycle.

Results
The average time spent in the study was 63.3 (SD 33.0) days with 9 of the 42 individuals dropping out within 2 weeks of the start of the study. We collected partial data from 114 ovulatory cycles, encompassing 33 participants, and obtained complete data from a total of 50 cycles. Participants reported a total of 2468 symptoms in the daily questionnaires administered during the luteal phase and menses. Despite difficulties with data completeness, the combined questionnaire and sensor data collection was technically feasible and provided interesting biological insights. We observed an increased heart rate in the mid and end luteal phase compared with menses and participants with severe premenstrual syndrome walked substantially fewer steps (average daily steps 10,283, SD 6277) during the luteal phase and menses compared with participants with no or low premenstrual syndrome (mean 11,694, SD 6458).

Conclusions
We demonstrate the feasibility of using an app-based approach to collect combined wearable device and questionnaire data on menstrual cycles. Dropouts in the early weeks of the study indicated that engagement efforts would need to be improved for larger studies. Despite the challenges of collecting wearable data on consecutive days, the data collected provided valuable biological insights, suggesting that the use of questionnaires in conjunction with wearable data may provide a more complete understanding of the menstrual cycle and its impact on daily life. The biological findings should motivate further research into understanding the relationship between the menstrual cycle and objective physiological measurements from sensor devices.