bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shock Wave Evaluation in Shell and Tube Heat Exchanger Tube Rupture Scenario
Authors: Terenzi Alessandro 
Published: January 2024

Abstract
Shell and Tube Heat Exchangers (STHEs) are commonly used in oil and gas plants to cool or heat process fluids. A possible issue when designing such systems is represented by the tube rupture scenario, when the internal HP (high-pressure) fluid is suddenly discharged to the LP (low-pressure) fluid in the shell. Since, usually, the tube and shell sides have different design pressures, this scenario must be analyzed to assess if the safety measures are fit to protect the weakest part of the system. The time evolution of this event is characterized by different phases; in the first one, a shock wave is generated and propagated very rapidly in the system, with a time scale in the order of a few ms. The phenomenon is so rapid that pressure relief devices are not effective. This kind of wave is normally not evaluated in the majority of available publications; however, it is deemed that it is of particular relevance for large-size SHTEs, due to their significant investment cost, and hence, a methodology has been developed in this work for the purpose. The main impact of such waves is expected in the LP piping connected to the exchanger. The amplitude of the shock wave at the source location, i.e., at the ruptured tube, is calculated based on the theory of the Riemann problem, with reference to different types of HP and LP fluids. Then, the relevant propagation up to the piping entrance is studied to estimate the wave damping and the effective wave amplitude impacting it. Both validation calculations and calculations referred to new design applications and existing installations are presented, and possible mitigation measures are proposed, if any.
Life in the Cambrian shallows: Exceptionally preserved arthropod and mollusk microfossils from the early Cambrian of Sweden
Authors: Slater Ben J. 
Published: January 2024

Abstract
Burgess Shale–type (BST) Lagerstätten record an exceptional variety of Cambrian soft-bodied fauna, yet these deposits are typically restricted to outboard depositional settings &gt;1000 km from the paleocoastline. For shallow, well-oxygenated shelf environments, our knowledge of non-mineralized animals (the majority of diversity) is severely limited, giving rise to substantial bias in our perception of Cambrian biotas. An alternate means of detecting soft-bodied Cambrian fauna, independent of paleobathymetry, is to use acid maceration to extract microscopic organic remains of non-mineralized animals, known as “small carbonaceous fossils” (SCFs). Here, a hitherto unknown diversity of Cambrian arthropod and mollusk remains are reported from shallow-marine sediments (Cambrian Stage 3 Mickwitzia Sandstone, Sweden). These microfossils comprise a variety of arthropod cuticles preserving sub-micron-scale anatomy alongside abundant radular mouthparts from mollusks—among the oldest known arthropod and molluscan SCFs on record. Significantly, at least three distinct types of fossil radula are identifiable (uniseriate, distichous, and polystichous forms), revealing that substantial diversification of the basic molluscan radula had already taken place by the early Cambrian. These cryptic elements of the biota—otherwise undetectable in such deposits—offer novel insights into Cambrian primary consumers as well as aspects of the fauna that are absent from deeper-water BST deposits.
High-Frequency Shift and Extension of the Terahertz Radiation Spectrum up to 10 THz During Optical Rectification of High-Power Few-Cycle Near-Infrared Femtosecond Pump Radiation in a BNA Crystal
Authors: Rumiantsev B. V. , Zhidovtsev N. A. , Pushkin A. V. , Lobushkin E. A. , Shulyndin P. A. , Suleimanova D. Z. , Savel’ev-Trofimov A. B. , Potemkin F. V. 
Published: January 2024

The generation of terahertz radiation in a BNA crystal pumped by 1.24-µm femtosecond laser radiation from a Cr:forsterite laser system with a pulse duration of 100 and 35 fs and a pump density of 10 mJ/cm2 has been realized. The achieved generation efficiency is 0.1%. It is found that a decrease in the pump pulse duration from 100 to 35 fs leads to the generation of high-frequency components in the ranges of 2.5–6.5 THz and 9‒10.5 THz in the generated radiation spectrum. Simulation of the terahertz radiation generation based on the solution of Maxwell’s equations by the finite-difference time-domain method has made it possible to adequately describe the measured spectra. The generation of broadband high-frequency terahertz radiation in the BNA crystal pumped by the Cr:forsterite laser system allows one to consider this schematic as an alternative to sources based on the BNA crystal pumped by a Ti:sapphire laser system.
Primary cerebral immunoglobulin light chain amyloidoma in a patient with multiple sclerosis
Authors: Traets Marissa J M , Chuwonpad Krisna , Leguit Roos J , Frequin Stephan T F M , Minnema Monique C 
Published: January 2024

A man in his 60s, known with multiple sclerosis, presented with seizures and paresis of the left arm and leg. Brain imaging showed a white matter lesion, right parietal, which was progressive over the last 6 years and not typical for multiple sclerosis. Brain biopsy showed a B-cell infiltrate with IgA lambda monotypic plasma cell differentiation and amyloid deposits, typed as lambda immunoglobulin light chain (AL). Bone marrow biopsy and PET/CT ruled out a systemic lymphoma. Extended history taking, blood and urine testing (including cardiac biomarkers) identified no evidence of systemic amyloidosis-induced organ dysfunction.Primary cerebral AL amyloidoma is a very rare entity where optimal treatment is difficult to assess. The patient was treated with locally applied volumetric modulated arc radiotherapy, 24 Gy, divided in 12 fractions. Afterwards, the paresis of the left arm partially resolved, and the function of the left leg improved. Seizures did not occur anymore.
Subsequent development of Kawasaki disease following acute human adenovirus infection among siblings
Authors: Sankannaavr Ashwini , Puttalinga Divyashree , Bagalkot Praveen S 
Published: January 2024

We report a middle-childhood girl presented with high-grade fever and headache for 4 days. Following this, the child developed mucocutaneous symptoms. She had a notable family history of autoimmune disease. Tests revealed increased inflammatory markers. On the sixth day of illness, a two-dimensonal echocardiogram showed an enlarged coronary artery, diagnosed as incomplete Kawasaki disease (KD) and treated with IVIG and aspirin.Within a week, her younger sibling, an early-childhood girl presented with features of viral prodrome, developed mucocutaneous lesions and subcutaneous oedema of limbs. Her investigations also showed elevated inflammatory markers and echocardiographic changes, diagnosed as incomplete KD.The subsequent development of KD in siblings, both showing initial viral symptoms and a family history of autoimmune disease, led to the suspicion of a potential viral trigger. This was confirmed through viral PCR studies for human adenovirus (type 3). These cases highlight an unusual occurrence of KD developing in siblings following acute adenoviral infection.
Association between antidepressant use during pregnancy and miscarriage: a systematic review and meta-analysis
Authors: Smith Sophie , Martin Flo , Rai Dheeraj , Forbes Harriet 
Published: January 2024

BackgroundLiterature surrounding the association between antidepressant use during pregnancy and miscarriage is conflicting. We aimed to conduct a systematic review and meta-analysis of studies among pregnant women regarding the association between exposure to antidepressants during pregnancy and the risk of miscarriage, compared with pregnant women not exposed to antidepressants.DesignWe conducted a systematic review and meta-analysis of non-randomised studies.Data sourcesWe searched Medline, Embase and PsychINFO up to 6 August 2023.Eligibility criteria and outcomesCase-control, cohort and cross-sectional study designs were selected if they compared individuals exposed to any antidepressant class during pregnancy to comparator groups of either no antidepressant use or an alternate antidepressant.Data extraction and synthesisEffect estimates were extracted from selected studies and pooled using a random-effects meta-analysis. Risk of bias (RoB) was assessed using the Risk of Bias in Non-Randomised Studies of Interventions (ROBINS-I) tool, and heterogeneity assessed using the I2statistic. Subgroup analyses were used to explore antidepressant classes and the impact of confounding by indication.Results1800 records were identified from the search, of which 29 were included in the systematic review and meta-analysis. The total sample included 5 671 135 individuals. Antidepressant users initially appeared to have a higher risk of miscarriage compared with unexposed individuals from the general population (summary effect estimate: 1.24, 95% CI 1.18 to 1.31, I2=69.2%; number of studies (n)=29). However, the summary estimate decreased when comparing against unexposed individuals with maternal depression (1.16, 1.04 to 1.31; I2=58.6%; n=6), suggesting confounding by indication may be driving the association. 22 studies suffered from serious RoB, and only two of the 29 studies were deemed at moderate RoB.ConclusionsAfter accounting for maternal depression, there is little evidence of any association between antidepressant use during pregnancy and miscarriage. Instead, the results indicate the biasing impact of confounding by indication.
Patients’ experiences with receiving sick leave certificates via remote consultations in Norway during the COVID-19 pandemic: a nationwide online survey
Authors: Zanaboni Paolo , Bergmo Trine S , Kristiansen Eli 
Published: January 2024

ObjectivesTo explore patients’ experiences with receiving sick leave certificates via remote consultations during the COVID-19 pandemic and investigate whether there were differences among the types of remote consultation (telephone, video or text).DesignA nationwide online patient survey consisting of quantitative data supplemented by qualitative opinions conducted in Norway.SettingPrimary care.ParticipantsPatients who received a sick leave certificate via remote consultation in the period from 16 November to 15 December 2020.ResultsOf the 5429 respondents, 3233 (59.6%) received a sick leave certificate via telephone consultation, 657 (12.1%) via video consultation and 1539 (28.3%) via text-based e-consultation. Most respondents (76.8%) were satisfied. Only 10% of the respondents thought that the doctor would have obtained more information through an office appointment. The majority of the respondents (59.6%) found that they had as much time to explain the problem as at an office appointment. Some patients also thought that it was easier to formulate the problem via a remote consultation (18.2%) and agree with the doctor on the sick leave (10.3%).The users of text-based e-consultations were the most satisfied (79.3%, p<0.001) compared with those using telephone or video consultations. Among users of text-based e-consultations, there was a higher proportion of patients who thought that they had more time to explain the problem compared with an office appointment (p<0.001), it was easier to explain the problem (p<0.001) and agree with the doctor (p<0.001). Most respondents would use the same type of remote consultation if they were to contact the general practitioner (GP) for the same problem, with the highest proportion among the users of video consultations (62.1%, p<0.001).ConclusionsPatients were satisfied with communicating and receiving sick leave certificates via remote consultations. Future studies should investigate patients’ and GPs’ use and experiences in a postpandemic setting.
Understanding aims, successes and challenges of palliative care and homelessness initiatives across the UK: an exploratory study
Authors: Crooks Jodie , Flemming Kate , Shulman Caroline , Hudson Briony 
Published: January 2024

BackgroundDue to the recognition that people experiencing homelessness (PEH) often die young and unsupported, a growing number of initiatives focusing on palliative care and homelessness are emerging across the UK. However, there has been no systematic exploration of the nature and landscape of this work.AimsTo understand the range, aims, successes and challenges of current initiatives within the field of palliative care and homelessness in the UK, by exploring existing projects and initiatives.MethodAn online survey was distributed to members of an Extension for Community Healthcare Outcomes network focusing on palliative care and homelessness for a mixed professional audience. The survey collated the aims, successes and challenges of initiatives aiming to improve palliative care for PEH. Responses were summarised using descriptive statistics, and free-text responses were analysed using thematic analysis.Results162 professionals completed the survey. Of these, 62% reported involvement in at least one palliative care and homelessness initiative. Initiatives focused on service delivery (59%), training (28%) and research (28%). Themes for success included improved service engagement, relationship formation, housing provision, honouring end-of-life wishes, upskilling staff and enabling safe hospital discharge. The main challenges included stigma around substance misuse, securing funding, staff capacity, equipment and facilities, and engaging communities.ConclusionThe number and scope of initiatives aiming to support PEH with advanced ill health and palliative care needs across the UK is growing, with a range of professionals engaging in the field. Future research may benefit from exploring initiatives in more detail to understand the specific drivers of impact on PEH and the staff and services supporting them.
Quantifying the carbon footprint of clinical trials: guidance development and case studies
Authors: Griffiths Jessica , Fox Lisa , Williamson Paula R 
Published: January 2024

BackgroundThe urgency of the climate crisis requires attention from biomedical research, not least clinical trials which can involve significant greenhouse gas emissions. The Low Carbon Clinical Trials Working Group set out a strategy to reduce the emissions of clinical trials, starting with the development of a method to measure their carbon footprint (CO2e).MethodsAs a first step, we developed a process map defining clinical trial core activities. Corresponding emission factors were sourced to convert activity data into greenhouse gas emissions. The subsequent method was applied to two Cancer Research UK (CRUK)-funded trials (the international randomised sarcoma trial CASPS (ISRCTN63733470) and the UK cohort-based breast cancer trial PRIMETIME (ISRCTN41579286)). A guidance document defining the scope, method and assumptions was written to allow application to any publicly funded/investigator initiated clinical trial.ResultsTrial specific activities over and above routine care were grouped into 10 modules covering trial set up, conduct and closure. We identified emission factors for all trial activities within both trials and used them to estimate their total carbon footprint. The carbon footprint of CASPS, an international phase 2 trial of an investigational medicinal product with 47 participants, was 72 tonnes CO2e, largely attributable to clinical trials unit emissions and staff travel. PRIMETIME, a UK-based phase 3 non-investigational medicinal product trial with 1962 patients, produced 89 tonnes CO2e, largely attributable to trial-specific in-person participant assessments.ConclusionWe have developed a method and guidance that trialists can use to determine the carbon footprint of clinical trials. The guidance can be used to identify carbon hotspots where alternative approaches to trial design and conduct could reduce a trial footprint, and where methodology research is required to investigate the potential impact of interventions taken to reduce carbon emissions. We will continue to refine the guidance to increase the potential application and improve usability.
The trajectory and influencing factors of disability acceptance in patients with hypertensive intracerebral haemorrhage: a protocol for prospective longitudinal cohort study in Heyuan City, China
Authors: Zhang Jia , Liu Xi , Zhang Zuolian 
Published: January 2024

IntroductionChina is one of the countries with the highest burden of hypertensive intracerebral haemorrhage (HICH), and its morbidity and mortality rates are almost twice the world average. Most survivors experience negative emotions such as anxiety and depression due to symptoms such as speech disorders, dysphagia, cognitive impairment, hemiplegia and ataxia. While evidence has emerged, supporting the acceptance of disability is a major factor in psychosocial adjustment of patients with disabilities. However, most relevant studies mainly focus on cross-sectional design, and the impact of disability on physical and mental health is a complex and comprehensive process, and its mechanism is still unclear. Therefore, we aimed to use the latent growth mixture model (LGMM) and the decision tree model to analyse the trajectory and predictors of disability acceptance in patients with HICH from stable hospitalisation to 2 years after discharge.Methods and analysisThe objective of this prospective study will be to examine the 2-year trajectory of disability acceptance in a cohort of persons with HICH. 180 participants will be recruited, and baseline general data collection, disability acceptance, family caring index and self-efficacy of chronic disease will be conducted. All of them will be followed up at the stable hospitalisation period, 6 month, 1 year and 2 year after discharge using the same protocol. As a major result, disability acceptance trajectories and potential categories will be analysed using LGMM. Additionally, the independent variables with statistical significance will be included in the decision tree model, and the Classification And Regression Trees（CART） algorithm programme will be used to construct the prediction model of influencing factors of disability acceptance trajectory. The exploratory outcome will provide scientific basis for the optimal intervention time point and the formulation of rehabilitation measures for this population.Ethics and disseminationEthical approval was obtained from the medical research ethics committee of Heyuan People’s Hospital (YXYJLL-2022S58). The results will be disseminated nationally and internationally through the publication of research papers.Trial registration numberChiCTR2300071778.
Etrolizumab as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis: a protocol of systematic review and meta-analysis of placebo-controlled, randomised clinical trials
Authors: Qin Xuan , Wang Menghui , Zhang Wei , Liu Wenji , Shu Hongxin , Xiong Xiaowei 
Published: January 2024

IntroductionEtrolizumab is a gut-targeted, anti-β7 integrin, monoclonal antibody. Recently, data from phase 2 and 3 trials presented different results in patients with moderately to severely active ulcerative colitis. The aim of this study is to summarise the latest published trials to analysis the role of etrolizumab in treatment of moderately to severely active ulcerative colitis during induction and maintenance phases.MethodsEligible randomised controlled trials (RCTs) will be retrieved from following databases: PubMed, Web of Science and the Cochrane Library. The last search time is May 2023. Two reviewers will independently identify RCTs according to inclusion and exclusion criteria. The primary outcome is clinical remission. The second outcomes are clinical response, endoscopic remission, endoscopic improvement, histological remission, any adverse event. The Grades of Recommendations, Assessment, Development and Evaluation tool will be established to estimate the evidence level of each outcome. All compute will be accomplished with Stata V.17.0 software.Ethics and disseminationThis systematic review and meta-analysis will be disseminated through peer-reviewed journals. No ethical approval requirements are required because the results presented in this study are conducted based on published data.PROSPERO registration numberCRD42023415369.
Patient organisations’ views, motivations and experiences on patient involvement in cancer research: a pilot study in Portugal
Authors: Roquette Constança , Crisóstomo Sofia , Milagre Tamara , Ribeiro Rute Simões , Pedro Ana Rita , Valente André 
Published: January 2024

ObjectivesTo characterise Portuguese cancer-related patient organisations and analyse their views, motivations and experiences on patient involvement in cancer research.DesignA multistakeholder group, comprising patient representatives and researchers, codesigned a questionnaire after a literature review, online sessions and collaborative mind maps. In May 2021, a survey was conducted among representatives of Portuguese cancer-related patient organisations, focusing on four dimensions: experience in cancer research; perception of its outcomes; motivations and expectations on patient involvement in research; and organisation characteristics.ParticipantsTwenty-seven representatives from Portuguese cancer-related patient organisations responded to the questionnaire, corresponding to a 64% response rate.ResultsAmong the surveyed organisations, 26% have participated in clinical studies. Their involvement occurred in few stages of the research process and, mostly, with low levels of engagement. They showed ‘great interest’ in participating in most research steps, although this is not reflected in a high perception of influence over these same steps. More than half claimed to have contributed to the increase in patient recruitment and to a better understanding of informed consent by patients involved. Ensuring that research results are more aligned with the true needs of patients is the greatest motivation. Also, our results suggest that the organisation’s number of employees and its integration into a European/International network play a relevant role in patient involvement in research.ConclusionsThis study provides the first in-depth characterisation of Portuguese cancer-related patient organisations and their views, motivations and experiences on patient involvement in cancer research. Most importantly, this study revealed that most of these organisations show great interest in being involved in different R&D stages to ensure that research results are aligned with patients’ needs. Their motivation should be turned into greater and more meaningful involvement in practice, so that the cancer community can benefit from the outcomes of truly patient-centred research.