bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trigeminal neuralgia secondary to osteoma and vascular compression: illustrative case
Authors: Cao Chenglong , Li Mingwu , Wu Min , Jiang Xiaofeng 
Published: December 2023

BACKGROUND
Trigeminal neuralgia (TN) is a common neurosurgical issue that has a detrimental impact on patients’ quality of life. Osteoma at the petrous apex is a rare etiology of TN. Here, the authors present a case involving the co-occurrence of petrous osteoma and a vascular loop around the trigeminal nerve. Both exerted pressure or compression on the exit of the trigeminal nerve.

OBSERVATIONS
A 46-year-old male presented with a 3-year history of persistent severe pain in the right side of his face. Magnetic resonance tomographic angiography of the trigeminal nerve revealed an abnormal signal in the right prepontine cistern, along with a vascular loop accompanying the right trigeminal nerve. A computed tomography scan of the skull indicated a nodular calcified density. The combined anterior transpetrosal approach for petrous osteoma and microvascular decompression (MVD) for the offending vessel were successfully performed. The patient was discharged without any complications or facial pain.

LESSONS
Although extremely rare, TN simultaneously secondary to petrous osteoma and offending vessels should be considered in the diagnosis. In this case, the combined surgical removal of petrous osteoma and MVD for the offending vessels proved to be an effective treatment for TN secondary to osteoma and vascular compression.
Segmental extraneural lipomatosis of the superficial peroneal nerve: illustrative case
Authors: Wu Kitty Y , Raghunathan Aditya , Spinner Robert J 
Published: December 2023

BACKGROUND
Adipose lesions of nerve are rare tumors that can cause nerve symptoms from either intrinsic or extrinsic compression.

OBSERVATIONS
The authors present a case of a patient with a 10-year history of progressive, persistent leg pain and dorsal foot paresthesias/dysesthesias. Imaging revealed several nondistinct nodules of indeterminate significance along the course of the superficial peroneal nerve (SPN). Surgery demonstrated six distinct extraneural lipomas studded on a 10-cm segment of the main SPN and one of its muscular branches in the midleg. The lesions were adherent to the SPN, without an easy dissection plane; therefore, a neurectomy was performed. Histology revealed the nerve was associated with multiple extraneural lipomas with focal evidence of prior trauma. At 4 months postoperatively, the patient’s pain had resolved completely, and she was able to resume normal physical activities.

LESSONS
The current classification of adipose lesions of nerve includes intraneural and extraneural lipomas and lipomatosis of nerve (fibrolipomatous hamartoma). The unique features of the present case include the discrete and segmental nature of the extraneural lipomas adherent to the nerve. Its etiology is unknown, and the histology would be suggestive of either a traumatic or a degenerative process.
Hemifacial spasm caused by multiple vascular attachments due to remote compression effects of a dermoid cyst in the cerebellar hemisphere: illustrative case
Authors: Hirayama Kento , Tanei Takafumi , Kato Takenori , Hasegawa Toshinori , Ito Eiji , Nishimura Yusuke , Saito Ryuta 
Published: December 2023

BACKGROUND
Dermoid cysts located laterally in the posterior fossa are rare. The authors report the case of a dermoid cyst in the cerebellar hemisphere presenting with hemifacial spasm (HFS) caused by multiple vascular attachments due to remote compression effects.

OBSERVATIONS
A 48-year-old man presented with left HFS. Computed tomography showed a mass lesion in the left cerebellar hemisphere with calcification and erosion of skull bone. Magnetic resonance imaging showed no contrast enhancement of the lesion and a dural defect. The lesion compressed the brainstem and cerebellopontine cistern, but no vascular attachments to the facial nerve were seen. Tumor removal and microvascular decompression were performed. The lesion was composed of soft tissue containing oil-like liquid and hairs, and the border of the cerebellar arachnoid was clear. There were multiple vascular attachments to the root exit zone, facial nerve, and brainstem. After displacing these arteries, the intraoperative abnormal muscle response disappeared. Histopathological findings showed stratified squamous epithelium, keratin flakes, calcifications, and hairs. The HFS disappeared completely and has remained absent for 27 months.

LESSONS
The dermoid cyst originating from occipital bone compressed the cerebellar hemisphere, displacing multiple vessels and leading to HFS. Tumor removal and the removal of all vascular factors can completely resolve HFS.
ÂŞIK VEYSEL’İN ŞİİRLERİNE GASTRONOMİK BAKIŞ
Authors: GÖZGEÇ MUTLU Havva , AYDOĞDU ATASOY Özlem 
Published: December 2023

1894’te Sivas şehrine bağlı Şarkışla ilçesinin Sivrialan köyünde doğan ve 1973 yılında doğduğu köyde vefat eden Veysel’in hayatı 1931 yılında Sivas’ta düzenlenen Âşıklar Bayramına katılmasıyla değişmiş ve ünü köyünü aşarak tüm ülkeye yayılmıştır. Kırk yaşına kadar sazı eşliğinde usta malı eserler söyleyen Veysel bu yaştan sonra kendi şiirlerini yazmaya ve söylemeye başlamıştır. Geçimini diyar diyar dolaşıp hem çalıp hem de söyleyerek sağlayan halk şairinin günümüze kadar ulaşan 180 adet şiiri tespit edilmiştir. Veysel bu şiirlerinde aşk, gurbet, vatanseverlik başta olmak üzere pek çok konuyu ele almıştır. Bu konulardan birisi de toprak ve onun insanlığa sunduğu nimetlerdir. Âşık Veysel, eserlerinde toprak ve topraktan gelen nimetlere ayrı bir önem vermiş ve pek çok şiirinde meyve, sebze, tahıl ve bakliyat gibi gastronomik ögeleri sıklıkla kullanmıştır.
Bununla birlikte Âşık Veysel’in yaşadığı yirminci yüzyılın başlarında da Türk mutfağı oldukça zengindi. O dönemlerde yemek sofraları insanların bir araya geldiği, sohbet ettiği, hikâyeler anlattığı, sosyal ilişkiler kurduğu yerlerdi. Aynı şekilde Âşık Veysel’in yazdığı ve Anadolu’nun her bir köşesinde söylediği eserleri de yemek masaları gibi insanları bir araya getiren ve paylaşımı teşvik eden zengin bir mirası ifade etmekteydi. Bir bakıma Âşık Veysel yaşadığı coğrafyanın sahip olduğu gastronomik değerleri eserlerinde işlemekte bunu da sazıyla sözüyle dile getirmekte idi.
Çalışma, Âşık Veysel'in şiirlerindeki gastronomi ögelerini belirleyerek değerlendirmeyi amaçlamaktadır. Bu doğrultuda şairin 180 adet şiiri nitel araştırma yöntemlerinden biri olan içerik analizi kullanılarak incelenmiştir. Analiz için MAXQDA nitel araştırma programından yararlanılmıştır. Veysel’in şiirleri programa yüklenmiş ve şiirlerde yer alan gastronomik ögeler ortaya çıkarılmıştır. Çalışma sonucunda Âşık Veysel'in şiirlerinde toplam 52 adet gastronomik ögeye rastlanmıştır. Bu ögeler içinde en sık tekrarlanan ilk beş ögenin sırasıyla "bal", "meyve", "tuz", “ekmek” ve “buğday” olduğu tespit edilmiş ve bu ögelerin ne tür (gerçek, mecazi, benzetme, istiare gibi) anlamlar taşıdığı tartışılmıştır. Ayrıca ögelerin sıklığını görsel olarak da ifade edebilmek için kelime bulutu oluşturulmuştur. Bu ögelerin ortaya çıkarılmasının dönemin sosyo-kültürel ve ekonomik yapısı hakkında bilgiler vereceği düşünülmektedir. Alan yazında daha önce bu tür bir araştırmanın yapılmamış olması çalışmayı önemli kılan hususlardan biridir. Bu çalışmanın hem edebiyat hem de gastronomi bilim dallarına katkı sağlayacağı öngörülmektedir.
OPTIMALISASI UPAYA DETASEMEN KHUSUS 88 MARKAS BESAR KEPOLISIAN ANTI TEROR
Authors: Herwin Herwin Sulistyowati 
Published: December 2023

Upaya Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia dilakukan melalui tindakan preventif dan renfresif. Tindakan preventif ditujukan mengurangi kemungkinan terjadinya aksi teror, meliputi tehnik pencegahan kejahatan murni untuk memperkuat target serta prosedur untuk mendeteksi aksi teror. Faktor-faktor penghambat Detasemen Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia, antara lain: a) faktor sarana dan fasilitas, penggunaan teknologi yang canggih dapat menjadi suatu titik lemah pihak Detasemen 88 Anti Teror apabila pihak Detasemen 88 Anti Teror selalu bergantung kepada kecanggihan teknologi; b) Faktor Masyarakat, masih adanya dukungan terhadap tindak pidana terorisme dari sebagian masyarakat yang menganggap pelaku terorisme sebagai pahlawan; dan c) Faktor Budaya, ajaran agama tertentu yang disalahgunakan sebagai alasan pembenar tindak pidana terorisme, dengan menggunakan istilah Jihad sebagai pelindung membuat pelaku tindak pidana terorisme menganggap tindakan yang dilakukannya adalah benar sehingga dalam proses hukum pelaku tersebut tidak mau mengakui kesalahannya. Metode penelitian bersifat deskriptif, lokasi penelitian di Wilayah Hukum Polres Sukoharjo. Jenis penelitian adalah yuridis normatif. Data dan sumber data diperoleh dari data primer dan sekunder. hasil penenlitian menunjukkan bahwa Upaya Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia dilakukan melalui tindakan preventif dan renfresif. Tindakan preventif ditujukan untuk mengurangi kemungkinan terjadinya aksi teror, meliputi tehnik pencegahan kejahatan murni yang ditujukan untuk memperkuat target serta prosedur untuk mendeteksi aksi teror yang terencana Faktor-faktor penghambat Detasemen Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia, antara lain: a) faktor sarana dan fasilitas, penggunaan teknologi yang canggih dapat menjadi suatu titik lemah pihak Detasemen 88 Anti Teror apabila pihak Detasemen 88 Anti Teror selalu bergantung kepada kecanggihan teknologi; b) Faktor Masyarakat, masih adanya dukungan terhadap tindak pidana terorisme dari sebagian masyarakat yang menganggap pelaku terorisme sebagai pahlawan; dan c) Faktor Budaya, ajaran agama tertentu yang disalahgunakan sebagai alasan pembenar tindak pidana terorisme, dengan menggunakan istilah Jihad sebagai pelindung membuat pelaku tindak pidana terorisme menganggap tindakan yang dilakukannya adalah benar sehingga dalam proses hukum pelaku tersebut tidak mau mengakui kesalahannya
Changes in peripheral blood parameters of lambs with spontaneous eimeriosis
Authors: Filipenko O. V. 
Published: December 2023

In order to study the morphological and biochemical parameters of the blood of lambs affected by the causative agent of eimeria, an experimental group of animals of the Romanov breed, two months old, was formed. The lambs were spontaneously infected with the causative agent of eimeria, which was confirmed by laboratory and clinical studies. The second group of animals was free from eimeria and was kept separately. According to the results of blood tests of sick lambs, a decrease in the number of peripheral blood erythrocytes by 29.66 %, an increase in the total number of leukocytes by 47.12 % compared to the blood parameters of the control group of animals was revealed. A change in leukogram parameters was also noted: an increase in the number of eosinophils by 55.43 %, young neutrophils by 75 %. At the same time, there was a decrease in the number of rod-shaped neutrophils and an increase in the number of segmented neutrophils by 8.7 and 29.51 %, respectively. A decrease in the number of lymphocytes and monocytes by 31.68 and 12 %, respectively, was registered. Biochemical changes in the blood serum of sick lambs also underwent changes. A decrease in the content of total protein by 36.06 %, albumin by 13.09 % was established. An increase in the content of globulins and dysproteinemia was noted. Hemoglobin content was also reduced compared to blood parameters of healthy lambs by 32.25 %, as well as glucose content by 27.83 %. The activity level of ALT and AST increased by 43.43 and 33.15 %, respectively, as well as a slight decrease in GGT activity. The difference was statistically significant (Р < 0.01 and Р < 0.05). Differences in the blood parameters of sick lambs have been established and indicate a syndrome of the body's general inflammatory reaction, anemia, damage to the alimentary canal by the causative agent of eimeria and intoxication.
Governors and Electoral Hazard in the Allocation of US Federal Disaster Aid
Authors: Husted Thomas , Nickerson David 
Published: December 2023

<p>Public aid in the aftermath of an environmental dissaster may provide elected officials opportunities to engage in “electoral hazard,” where an incumbent can influence the probability of her reelection by allocating aid to influence voters’ expectations of their future welfare. This is the first test for electoral hazard in the allocation of federal public aid to officials of local governments running for re-election. Using a unique U.S. county-level data set, we estimate the determinants of the equilibrium allocation strategy of an incumbent in the presence of electoral hazard. Controlling for loss and the demographic, economic and political characteristics of at-risk counties, we find the average incumbent governor seeking re-election actively engages in the manipulation of voter expectations by allocating greater shares and magnitudes of the largest federal disaster aid program to those at-risk counties that awarded the incumbent governor a plurality of votes in the preceding election. </p>
KONULARI BAKIMINDAN İRAN'DA SÖYLENEN FARSÇA NİNNİLER ÜZERİNE BİR DEĞERLENDİRME
Authors: GEDİK Melek 
Published: December 2023

Sözlü edebiyat ürünleri arasında yer alan ninni çocuğun annesinden ilk işittiği kısa, yalın ve ritimli sözlerdir. Anne, dışarıdan herhangi bir müdahale olmaksızın söylediği bu ritimli ve nağmeli sözler aracılığıyla çocuğu ile ilk dilsel bağı kurmaktadır. Çocuğu uyutmak ve sakinleştirmek için söylenen bu sözler aynı zamanda bir toplumun dil, kültür ve sosyolojik özellikleri hakkında bilgi sunmaktadır. Ninniler genellikle anne tarafından icra edildiğinden kadın, sözlü kültür mirasının nesilden nesile aktarılmasında önemli bir rol üstlenmektedir. Anne, çocuğu doğduğu andan itibaren onun erken dönem eğitimini ninniler vasıtasıyla desteklemektedir. Çocuğa yaşadığı çevreyi, dilini, kültürünü, dinini, inançlarını, ulusal değerlerini tanıtarak onlarla bağ kurmasını ve içselleştirmesini sağlamada öğrenilmesi kolay ve akılda kalıcılığı yüksek olan ninnilerin etkisi büyüktür. Aynı zamanda anne kendine has bir üslupla dile getirdiği ninnilerde duygularını, isteklerini, sıkıntılarını ve beklentilerini iletmektedir. Bu bağlamda ninniler aile yapısının özelliklerini, aile bireyleri arasındaki ilişkileri, anne ve babanın aile içerisindeki rollerini ortaya koymaktadır.
Ninniler İran’da halk edebiyatının önemli bir bölümünü oluşturmaktadır. Halk edebiyatı ile ilgilenen İranlı birçok araştırmacı derleme faaliyetlerinde bulunarak ülkenin farklı bölgelerinden derledikleri ninnilere eserlerinde yer vermişlerdir. Bunun yanı sıra ninninin tanımı, muhtevası ve işlevi konusunda akademik anlamda birçok çalışma da kaleme alınmıştır. Bu çalışmada İran’da ninni konusunda yapılan tanımlamalar ve İran halk edebiyatında ninnilerin yeri ve önemi hakkında genel bilgiler verildikten sonra araştırmacıların İran’ın çeşitli şehirlerinden derlediği ninni örnekleri yapı ve konu bakımından değerlendirilecektir.
Case Report: Imaging features of a new type double inferior vena cava malformation and review
Authors: Wu Yu-lin , Yang Guo-kai , Chen Qian , Tang Yi , Zhang Jian-hui , Wu Shao-jie , Cai Sen-lin , Zhou Yan-feng , Zhu Yao-Bin , Luo Jie-wei , Fang Zhu-ting 
Published: December 2023

BackgroundDouble inferior vena cava (DIVC) is a rare vascular malformation. With advances in radiological techniques and diagnosis, more and more types of DIVC were identified and diagnosed. Recognition of the variety of DIVC seen on imaging is essential for subsequent venous interventions.Case presentationA 77-year-old man presented with low back pain with left lower limb pain for 1 month. Scattered petechiae above the skin surface on the left lower leg, especially on the extensor surface, with flaking and mild tingling of the skin, were noted 3 weeks ago. Ultrasound revealed deep vein thrombosis (DVT) in the left lower limb. Computed tomography pulmonary angiography (CTPA) suggested no significant thrombus in the pulmonary artery. Computed tomography venography (CTV) of bilateral lower limbs showed that iliac vein compression syndrome with formation of deep and superficial venous traffic branches in bilateral lower limbs, predominantly on the left side. CTV of the inferior vena cava (IVC) suggested that the left common iliac vein crossed the common iliac artery bifurcation from dorsal to ventral and continued to travel cranially as a ventral vessel, and connected with the ventral IVC anterior to the right common iliac artery. The right common iliac vein extended cephalad as a dorsal vessel, which was narrowed at the level of 4th lumbar vertebra by compression of the hyperplastic bone and the osteophyte. The patient was discharged after right and left common iliac vein angiography and balloon dilation of bilateral common iliac vein.ConclusionThe formation of both ventrally and dorsally aligned DIVC is rarer. It should be clarified the effects of DIVC on DVT formation, and the importance of imaging for preoperative planning.
Single-cell profiling reveals transcriptomic signatures of vascular endothelial cells in non-healing diabetic foot ulcers
Authors: Lu Yangzhou , Liu Xiaogang , Zhao Jingling , Bie Fan , Liu Yiling , Xie Julin , Wang Peng , Zhu Junyou , Xiong Yahui , Qin Shitian , Yang Fan , Chen Lei , Xu Yingbin 
Published: December 2023

BackgroundThe treatment of diabetic foot ulcers (DFUs) poses a challenging medical problem that has long plagued individuals with diabetes. Clinically, wounds that fail to heal for more than 12 weeks after the formation of DFUs are referred to as non-healing/chronic wounds. Among various factors contributing to the non-healing of DFUs, the impairment of skin microvascular endothelial cell function caused by high glucose plays a crucial role. Our study aimed to reveal the transcriptomic signatures of non-healing DFUs endothelial cells, providing novel intervention targets for treatment strategies.MethodsBased on the GEO dataset (GSE165816), we selected DFU-Healer, DFU-Non-healer, and healthy non-diabetic controls as research subjects. Single-cell RNA transcriptomic sequencing technology was employed to analyze the heterogeneity of endothelial cells in different skin tissue samples and identify healing-related endothelial cell subpopulations. Immunofluorescence was applied to validate the sequencing results on clinical specimens.ResultsThe number of endothelial cells and vascular density showed no significant differences among the three groups of skin specimens. However, endothelial cells from non-healing DFUs exhibited apparent inhibition of angiogenesis, inflammation, and immune-related signaling pathways. The expression of CCND1, ENO1, HIF1α, and SERPINE1 was significantly downregulated at the transcriptomic and histological levels. Further analysis demonstrated that healing-related endothelial cell subpopulations in non-healing DFUs has limited connection with other cell types and weaker differentiation ability.ConclusionAt the single-cell level, we uncovered the molecular and functional specificity of endothelial cells in non-healing DFUs and highlighted the importance of endothelial cell immune-mediated capability in angiogenesis and wound healing. This provides new insights for the treatment of DFUs.
Regulatory T cells in the peripheral blood of women with gestational diabetes: a systematic review and meta-analysis
Authors: Arain Hania , Patel Tina , Mureanu Nicoleta , Efthymiou Athina , Lombardi Giovanna , Tree Timothy , Nicolaides Kypros H. , Shangaris Panicos 
Published: December 2023

BackgroundGestational diabetes (GDM) affects approximately 14% of pregnancies globally and is associated with short- and long-term complications for both the mother and child. In addition, GDM has been linked to chronic low-grade inflammation with recent research indicating a potential immune dysregulation in pathophysiology and a disparity in regulatory T cells.ObjectiveThis systematic review and meta-analysis aimed to determine whether there is an association between GDM and the level of Tregs in the peripheral blood.MethodsLiterature searches were conducted in PubMed, Embase, and Ovid between the 7th and 14th of February 2022. The inclusion criteria were any original studies published in the English language, measuring differentiated Tregs in women with GDM compared with glucose-tolerant pregnant women. Meta-analysis was performed between comparable Treg markers. Statistical tests were used to quantify heterogeneity: τ2, χ2, and I2. Study quality was assessed using a modified version of the Newcastle-Ottawa scale.ResultsThe search yielded 223 results: eight studies were included in the review and seven in the meta-analysis (GDM = 228, control = 286). Analysis of Tregs across all trimesters showed significantly lower Treg numbers in women with GDM (SMD, −0.76; 95% CI, −1.37, −0.15; I2 = 90%). This was reflected in the analysis by specific Treg markers (SMD −0.55; 95% CI, −1.04, −0.07; I2 = 83%; third trimester, five studies). Non-significant differences were found within subgroups (differentiated by CD4+FoxP3+, CD4+CD127−, and CD4+CD127−FoxP3) of both analyses.ConclusionGDM is associated with lower Treg numbers in the peripheral maternal blood. In early pregnancy, there is clinical potential to use Treg levels as a predictive tool for the subsequent development of GDM. There is also a potential therapeutic intervention to prevent the development of GDM by increasing Treg populations. However, the precise mechanism by which Tregs mediate GDM remains unclear.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42022309796.
Deciphering the rule of antigen-antibody amino acid interaction
Authors: Jiang Min , Fang Changyin , Ma Yongping 
Published: December 2023

PurposeAntigenic drift is the biggest challenge for mutagenic RNA virus vaccine development. The primary purpose is to determine the IEMM (immune escape mutation map) of 20 amino acids’ replacement to reveal the rule of the viral immune escape.MethodsTo determine the relationship between epitope mutation and immune escape, we use universal protein tags as a linear epitope model. To describe and draw amino acid linkage diagrams, mutations of protein tags are classified into four categories: IEM (immune escape mutation), ADERM (antibody-dependent enhancement risk mutation), EQM (equivalent mutation), and IVM (invalid mutation). To overcome the data limitation, a general antigen-antibody (Ag-Ab) interaction map was constructed by analyzing the published three-dimensional (3D) Ag-Ab interaction patterns.Results(i) One residue interacts with multiple amino acids in antigen-antibody interaction. (ii) Most amino acid replacements are IVM and EQM. (iii) Once aromatic amino acids replace non-aromatic amino acids, the mutation is often IEM. (iv) Substituting residues with the same physical and chemical properties easily leads to IVM. Therefore, this study has important theoretical significance for future research on antigenic drift, antibody rescue, and vaccine renewal design.ConclusionThe antigenic epitope mutations were typed into IEM, ADERM, EQM, and IVM types to describe and quantify the results of antigenic mutations. The antigen-antibody interaction rule was summarized as a one-to-many interaction rule. To sum up, the epitope mutation rules were defined as IVM and EQM predomination rules and the aryl mutation escape rule.