bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОКРЕМІ ПИТАННЯ ЩОДО ВИТРЕБУВАННЯ ДОКАЗІВ У ГОСПОДАРСЬКОМУ ПРОЦЕСІ
Authors: Минюк О. Ю. , Лупай А. С. 
Published: December 2023

Статтю присвячено аналізу окремих питань щодо витребування доказів у господарському процесі. У вирішенні господарського спору провідне місце посідає дослідження та витребування доказів, які містять інформацію про обставини справи. Питання витребування доказів залишається одним з способів захисту стороною її інтересів. Уже на стадії підготовки позову позивач має визначити чіткий перелік доказів, якими будуть обґрунтовуватись заявлені позовні вимоги, додати дані докази до позовної заяви, а в разі їх відсутності – вирішувати питання про їх витребування. Проте і тут може виникнути ряд проблем, однією із яких є відсутність доказів. Це може статися у випадку, коли докази втрачені або знищені, або коли їх немає зовсім. Відсутність доказів ускладнює розгляд справи та може призвести до невизначеності рішення.
Іншим питанням, пов’язаним з витребуванням доказів, є недостатня досто­вірність доказів, яка може бути спричинена помилками у збиранні або обробці доказів, або використанням недостовірних джерел.
Не менш важливою проблемою є питання витребування електронних доказів. Сьогодні обставини багатьох господарських правопорушень значною мірою можуть бути доведені за допомогою електронних доказів, які мають відповідати встановленим законом критеріям та характеристикам, щоб не виникало питання про їх недопустимість, а суд міг покласти їх в основу свого судового рішення.
В Україні, як і в Європейському Союзі, витребування доказів регулюється законодавчими актами, які визначають правила витребування доказів та засоби їх забезпечення. Однак існують актуальні проблеми, які потребують уваги та розв’язання, зокрема питання дозволу на витребування доказів та доведення достовір­ності електронних доказів. У процесі витребування доказів важливо враховувати права та інтереси сторін у справі, оскільки обмеження їх прав може призвести до нездатності захистити свої права та інтереси в повному обсязі. Тому дозвіл на витребування доказів повинен бути обґрунтованим та необхідним для забезпечення об'єктивності та надійності доказів.
ВИКЛИКИ СУЧАСНОЇ КІБЕРБЕЗПЕКИ: ІНСТИТУЦІЙНІ І ПРАВОВІ ВІДПОВІДІ НІМЕЧЧИНИ
Authors: Павлюх О. А. , Санжарова Г. Ф. , Санжаров В. А. 
Published: December 2023

Стаття присвячена дослідженню німецької концепції кібербезпеки та її інститу­ційного і законодавчого наповнення. Новітні «розумні» системи та технології, що лежать в основі повсякденного життя, такі як електромережі, системи управління повітряним рухом, супутники, медичні технології, промислові підприємства та світлофори, підключені до інтернету, потенційно наражаються на небезпеку несанкціонованого віддаленого втручання. Способи протидії інформаційним загрозам і ризикам різних країн формуються по-різному.
У статті проаналізовано законодавчі кіберініціативи німецького уряду впродовж останніх десятиліть. Німецьке законодавство намагається враховувати зміни кібернетичного, геополітичного та технологічного ландшафту (поява аналітики великих даних, автономних систем, надійних промислових систем управління, кіберфізичних систем та «інтернету речей», технологій «інтелектуального міста», автоматизованої верифікації систем) та створити дієву систему кібербезпеки, за якої створення продуктів, систем та послуг є «безпечними за умовчанням». Констатовано, що унікальною рисою німецького законодавства є визначення такою, що потребує захисту поруч з об’єктами критичної інфраструктури, категорії «важливих» об’єктів.
Зазначено, що кібербезпекова стратегія Німеччини використовує невійськовий підхід, не пропонує включення кіберструктур Бундесверу до Національного центру реагування чи Національної ради з кібербезпеки, не розглядає можливості проведення упереджувальних наступальних кібероперацій. Можна вважати доведеним, що подальше розширення інструментів, які є в розпорядженні німецького уряду та військових, для роботи в кіберсфері залишається обмеженим жорсткими правовими нормами.
Автори вважають безперечним, що Німеччина завдяки своїм різноманітним зусиллям у юридичній, технологічній та виробничій сферах, постійному вдосконаленню політики, правил і законодавства наразі готова долати виклики та загрози, властиві кіберсфері. Зроблено висновок, що далекоглядний характер законодавчих зусиль робить Німеччину одним з лідерів в ЄС і на світовій арені в питаннях кібербезпеки.
Is the obesity paradox in outpatients with heart failure reduced ejection fraction real?
Authors: Salvino Nathália Felix Araujo , Sousa Lyz Tavares de , Abrahao Fabio Maia , Spineti Pedro Pimenta de Mello , Sales Ana Luiza Ferreira , Neves de Albuquerque Felipe , Bittencourt Marcelo Imbroinise , de Moraes Pedro Castello Branco , Esporcatte Roberto , Mourilhe-Rocha Ricardo 
Published: December 2023

BackgroundThe obesity occurrence has achieved epidemic levels worldwide and several studies indicate a paradoxical similarity among obesity and the prognosis in heart failure (HF). The primary objective was to understand the association between body mass index (BMI) and heart failure with reduced ejection fraction (HFREF) of ischemic etiology in outpatients, using mortality as a parameter. The secondary objectives were to determine the differences in HF functional class, pharmacological therapy and evaluate the prognostic value of MAGGIC Score in this population.MethodsWe analyzed 1,556 medical records from the HF outpatient clinic of a quaternary hospital and 242 were selected according to the criteria. Most were male, average age 62.6 (56–70), BMI 18.5–24.9 = 35.1%, 25–29.9 = 37.2%, 30–34.9 = 17.8%, 35–39.9 = 7%; BMI &lt;18.5 and &gt;40 groups were eliminated from the central analyzes because of scarce testing.ResultsBMI 30–34.9 and BMI 18.5–24.9 had the best prognosis, BMI 25–29.9 had an average performance, and BMI –39.9 group provided the worst outcome (p = 0.123). In the subcategory analysis, BMI 30–34.9 group had a better prognosis compared to the BMI 35–39.9 group (p = 0.033). In the multivariate analysis The MAGGIC score was not able to foretell mortality in this population according to BMI.ConclusionIn not hospitalized patients with HFREF of ischemic etiology, obesity was not a protective factor.
ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
Authors: Penack Olaf , Peczynski Christophe , Boreland William , Lemaitre Jessica , Afanasyeva Ksenia , Kornblit Brian , Jurado Manuel , Martinez Carmen , Natale Annalisa , Pérez-Simón Jose Antonio , Brunello Lucia , Avenoso Daniele , Klein Stefan , Ozkurt Zubeyde Nur , Herrera Concha , Wichert Stina , Chiusolo Patrizia , Gavriilaki Eleni , Basak Grzegorz W. , Schoemans Hélène , Koenecke Christian , Moiseev Ivan , Peric Zinaida 
Published: December 2023

IntroductionExtracorporal Photophoresis (ECP) is in clinical use for steroid-refractory and steroid-dependent acute GVHD (SR-aGVHD). Based on recent Phase-III study results, ruxolitinib has become the new standard of care for SR-aGVHD. Our aim was to collect comparative data between ruxolitinib and ECP in SR-aGVHD in order to improve the evidence base for clinical decision making. MethodsWe asked EBMT centers if they were willing to participate in this study by completing a data form (Med-C) with detailed information on GVHD grading, -therapy, -dosing, -response and complications for each included patient.Results31 centers responded positively (14%) and we included all patients receiving alloSCT between 1/2017-7/2019 and treated with ECP or ruxolitinib for SR-aGVHD grades II-IV from these centers. We identified 53 and 40 patients with grades II-IV SR-aGVHD who were treated with ECP and ruxolitinib, respectively. We performed multivariate analyses adjusted on grading and type of SR-aGVHD (steroid dependent vs. refractory). At day+90 after initiation of treatment for SR-aGVHD we found no statistically significant differences in overall response. The odds ratio in the ruxolitinib group to achieve overall response vs. the ECP group was 1.13 (95% CI = [0.41; 3.22], p = 0.81). In line, we detected no statistically significant differences in overall survival, progression-free survival, non-relapse mortality and relapse incidence.DiscussionThe clinical significance is limited by the retrospective study design and the current data can’t replace prospective studies on ECP in SR-aGVHD. However, the present results contribute to the accumulating evidence on ECP as an effective treatment option in SR-aGVHD.
Multifunctional composite with hybrid carbon fiber and carbonaceous coconut particle reinforcement
Authors: Feni Foster , Jahan Maryam , Zhao Rong , Li Guoqiang , Zhao Guang-Lin , Mensah Patrick F. 
Published: December 2023

The utilization of multifunctional composite materials presents significant advantages in terms of system efficiency, cost-effectiveness, and miniaturization, making them highly valuable for a wide range of industrial applications. One approach to harness the multifunctionality of carbon fiber reinforced polymer (CFRP) is to integrate it with a secondary material to form a hybrid composite. In our previous research, we explored the use of carbonaceous material derived from coconut shells as a sustainable alternative to inorganic fillers, aiming to enhance the out-of-plane mechanical performance of CFRP. In this study, our focus is to investigate the influence of carbonized coconut shell particles on the non-structural properties of CFRP, specifically electromagnetic interference (EMI) shielding, thermal stability, and water absorption resistance. The carbonized material was prepared by thermal processing at 400 °C. Varying proportions of carbonized material, ranging from 1% to 5% by weight, were thoroughly mixed with epoxy resin to form the matrix used for impregnating woven carbon fabric with a volume fraction of 29%. Through measurements of scattering parameters, we found that the hybrid composites with particle loadings up to 3% exhibited EMI shielding effectiveness suitable for industrial applications. Also, incorporating low concentrations of carbonized particle to CFRP enhances the thermal stability of hybrid CFRP composites. However, the inclusion of carbonized particle to CFRP has a complex effect on the glass transition temperature. Even so, the hybrid composite with 2% particle loading exhibits the highest glass transition temperature and lowest damping factor among the tested variations. Furthermore, when subjected to a 7-day water immersion test, hybrid composites with 3% or less amount of carbonized particle showed the least water absorption. The favorable outcome can be attributed to good interfacial bonding at the matrix/fiber interface. Conversely, at higher particle concentrations, aggregation of particles and formation of interfacial and internal pores was observed, ultimately resulting in deteriorated measured properties. The improved non-structural functionalities observed in these biocomposites suggest the potential for a more sustainable and cost-effective alternative to their inorganic-based counterparts. This advancement in multifunctional composites could pave the way for enhanced applications of biocomposites in various industries.
A predictive model for residual lesions after LEEP surgery in CIN III patients
Authors: Deng Lihui , Wang Tiejun , Chen Ye , Tang Xueli , Xiang Dajun 
Published: December 2023

Background and aimsThe residual lesions after Loop Electrosurgical Excision Procedure (LEEP) contributes to poor prognosis in patients with Cervical Intraepithelial Neoplasia Grade 3 (CIN3). The aim of this study is to establish an effective clinical predictive model for residual lesions in CIN3 patients after LEEP.MethodsA retrospective analysis was performed on 436 CIN3 patients who underwent total hysterectomy within 3 months after LEEP. Based on the post-hysterectomy pathologic, the patients were divided into the no residual group and residual group. Clinical parameters were compared between the two groups, and univariate and multivariate logistic regression analyses were conducted to identify independent risk factors for residual lesions in CIN3 patients after LEEP. Using R software, a nomogram model was established and its effectiveness was evaluated using calibration plots.ResultsThere were 178 cases in the residual group and 258 cases in the no residual group. The two groups had no significant difference in general characteristics (p &gt; 0.05). It was found that Post-LEEP follow-up HPV, Post-LEEP follow-up TCT, and the Gland involvement were independent risk factors for residual lesions in CIN3 patients after LEEP (all p &lt; 0.05). The consistency index (C-index) of the nomogram model for predicting residual lesions was 0.975 (0.962–0.988).ConclusionThe Post-LEEP follow-up HPV, Post-LEEP follow-up TCT, and Gland involvement are independent risk factors related to residual tissue after LEEP surgery in CIN3 patients. The constructed nomogram can effectively predict the presence of residual tissue after LEEP surgery in CIN3 patients and has good practical value.
The burden of epilepsy in the People’s Republic of China from 1990 to 2019: epidemiological trends and comparison with the global burden of epilepsy
Authors: Shu Yun , Wu Zhifeng , Yang Xiaolin , Song Min , Ye Yangyang , Zhang Chunqing , Yuan Qing , Wang Li 
Published: December 2023

BackgroundEpilepsy is associated with a significant global burden of disease, affecting over 50 million people worldwide. The specific aim of this study is to compare the burden of epilepsy in the People’s Republic of China (PRC) with the global burden, and to analyze the epidemiological trends of epilepsy, the relationship between the burden of epilepsy and social demographic index (SDI), and the relative contributions of epidemiological factors.MethodsThis is a retrospective population-based study, data were obtained from the Global Burden of Disease (GBD) study in 2019. We employed Joinpoint software and the age-period-cohort (APC) model to analyze epilepsy’s epidemiological trends. Health inequality analysis was conducted to investigate the impact of SDI on epilepsy burden. Decomposition analysis was performed to examine the relative contributions of age, population, and epidemiological changes to epilepsy.ResultsBetween 1990 and 2019, the incidence rate in the PRC increased by 45%, significantly surpassing the global incidence of epilepsy. However, Disability-Adjusted Life Years (DALY) decreased notably, and the proportion of Years of Life Lost (YLL) decreased from 62.73 to 39.03%. Concerning incidence, the period Rate Ratio (RR) in the PRC initially increased and then decreased, while the cohort RR in the PRC and globally exhibited a consistent upward trend. In terms of mortality, period RR and cohort RR in the PRC displayed a gradual decrease, with mortality starting higher but eventually falling below the global mortality. The net drifts of incidence were greater than 0, whereas the net drifts of mortality were less than 0, both were lower in the PRC than at the global level. Decomposition analysis indicated that the changes of incidence and mortality in the PRC were mainly attributed to epidemiological changes. Additionally, global disparities in epilepsy decreased, with the burden concentrating in low SDI countries.ConclusionThe incidence of epilepsy in the PRC rose during the 30-year study period, while epilepsy mortality decreased. The improved survival rate in the PRC is predominantly attributable to epidemiological changes. The burden of epilepsy in the PRC predominantly affects males, children, and the elderly, Chinese government should focus on specific populations.
Retinal arterial–venous pulse delay: a new specific marker for a carotid–cavernous fistula
Authors: Linton Edward F. , Tedeschi Thomas R. , Ahmad Noor-Us-Sabah , Wang Jui-Kai , Kardon Randy H. 
Published: December 2023

PurposeThe purpose of the study was to describe ocular blood flow changes in eyes affected by a carotid–cavernous fistula (CCF) using laser speckle flowgraphy. We hypothesized that imaging blood flow velocity waveforms in the retinal arterioles and venules simultaneously would reveal specific characteristics of an arteriovenous (AV) connection.DesignThe study was an observational case series, with a retrospective case–control analysis.MethodsFive patients with a CCF underwent measurement of ocular blood flow using laser speckle flowgraphy. The blood flow was compared retrospectively between a control group of healthy subjects (n = 32) and patients with an elevated intraocular pressure or venous outflow impairment without an AV fistula (n = 40). The outcomes were derived from the arteriole and venule blood flow velocity waveforms, including an A–V phase delay and flow pulsatility.ResultsThe presence of an active CCF was associated with an increased delay in the peak velocity measured in the retinal venule (10.7% ± 2.2% of the cardiac cycle duration) compared with unaffected fellow eyes (1.8% ± 0.2%; p = 0.05) or control eyes of normal subjects (2.7% ± 0.3%; p = 0.02). This delay disappeared after fistula thrombosis and was not present in eyes with a central retinal vein occlusion (CRVO), glaucoma, non-arteritic anterior ischemic optic neuropathy (NAION), or papilledema. The venule blood flow velocity decreased during systole (and in some cases momentarily stopped), leading to a delayed pulse with a greater amplitude in the venules than in fellow eyes and normal controls after normalizing to the arteriole amplitude (1.71 ± 0.3 vs 0.54 ± 0.03 vs 0.59 ± 0.02; p = 8.0E-12). This specific AV delay could also be identified in a scanning laser ophthalmoscope (SLO; SPECTRALIS®) video.ConclusionLaser speckle flowgraphy reveals dynamic retinal vascular changes in eyes affected by a CCF, which are not present in healthy controls or patients with other eye conditions, and which reverses with treatment.
Dose-effect relationship of different acupuncture courses on chronic insomnia disorder: study protocol for a randomized controlled trial
Authors: Zhu Fengya , Liu Junqian , Wang Yuan , Ma Tingting , Wang Tianyu , Yang Bin , Miao Runqing , Wu Jie 
Published: December 2023

BackgroundChronic insomnia disorder (CID) is increasing in prevalence year by year, is long lasting, and potentially risky. Acupuncture has been widely used in the clinical management of this condition. However, there is still a lack of direct evidence on the dose-effect relationship between different acupuncture courses and clinical efficacy. To identify this relationship, we will design a randomized controlled trial to clarify the difference in efficacy of different acupuncture courses for CID.Methods and designThis is a prospective, parallel, single center randomized controlled trial. Two hundred and one participants with CID will be randomly divided into three groups (Group A, Group B, and Group C). The three groups will be given acupuncture therapy for 4, 6, and 8 weeks, three sessions per week, with at least 1 day between sessions. Follow-up will continue until the third month after the end of treatment. The primary outcome is the Insomnia Severity Index (ISI), and secondary outcomes include percentage of ISI &lt; 8 points, the Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Fatigue Severity Scale (FSS), medication use, and safety.DiscussionThis study is expected to provide direct evidence for the optimal treatment cycle of acupuncture for CID, as well as to facilitate health economic evaluation.Clinical trial registrationhttps://clinicaltrials.gov/, identifier [ChiCTR2300073711].
Current Status and Influencing Factors of Snakebite Diagnosis and Treatment Knowledge Among Medical Staff in China: A Cross-Sectional Study
Authors: Hu Yanlan , Lv Chuanzhu , Song Xingyue , Gan Yong , Wang Juntao , Hao Wenjie , He Lanfen , Chen Yu , Han Xiaotong , Yan Shijiao 
Published: December 2023

Objectives: This study aimed to determine the current status of the knowledge of diagnosis and treatment of snakebites among medical staff in China and its influencing factors.Methods: A cross-sectional survey of 12,581 medical staff was conducted in 12 provinces in China between June 2022 and February 2023. We analyzed the results using descriptive statistics, T-tests or analysis of variance, and a generalized linear model.Results: The average score of snakebite diagnosis and treatment knowledge among medical staff in China was 3.15 ± 2.15 out of a total score of 12. Through a generalized linear regression model, we found that gender, occupation, region, hospital level, work department, work tenure, training received in the diagnosis and treatment of snakebite, experience in snakebite diagnosis and treatment, availability of antivenom in the unit, and self-evaluation of snakebite treatment ability all affected the medical staff’s scores of snakebite diagnosis and treatment knowledge.Conclusion: The knowledge level of snakebite diagnosis and treatment among Chinese medical staff is generally low, so it is imperative to conduct standardized snakebite diagnosis and treatment training for medical staff.
RANCANG BANGUN SISTEM INFORMASI PENJUALAN BERBASIS CUSTOMER RELATIONSHIP MANAGEMENT (CRM) PADA USAHA MIKRO KECIL MENENGAH (UMKM) DI KABUPATEN JEPARA
Authors: Murod Alfarisi Agus , Mahendra Danang 
Published: December 2023

Pesatnya persaingan bisnis usaha mikro kecil menengah (umkm), menuntut pemilik usaha untuk menerapkan suatu strategi yang tepat, demi mendukung proses bisnisnya, salah satunya ialah metode pemasaran melalui media online dengan tujuan untuk menjangkau banyak pembeli. Realitanya media yang digunakan oleh UMKM selama ini untuk menjajakan barang masih memiliki kelemahan di mana pelanggan masih disulitkan pada saat melakukan transaksi. Penerapan Customer Relationship Management (CRM) pada pelanggan. Beberapa UMKM akan dijadikan objek dalam penelitian ini. Objek tersebut akan dianalisis menggunakan metode analisis SWOT untuk mengetahui dan mengevaluasi strategi yang tepat berkaitan dengan (strengths), kelemahan (weaknesses), peluang (opportunities), dan ancaman (threats) pada UMKM beserta dilengkapi dengan konsep CRM untuk membantu dalam menetukan fitur-fitur CRM yang diterapakan. Sehingga hasil yang diharapkan dalam penelitian ini adalah sebuah website e-marketplace dengan kelebihan dapat memberikan kemudahan dan keleluasaan UMKM dalam memberikan informasi yang dibutuhkan konsumen dan proses transaksi bisa dilakukan dengan lebih mudah Serta penerapan fitur CRM yang diharapkan dapat meningkatkan kualitas pelayanan terhadap kepuasan pelanggan.
Hemşirelerin İşyeri Nezaketsizliği ile Karşılaşma Durumları ve Memnuniyet Düzeylerine Etkileri
Authors: KUTLU Adalet , UTAR Abdulkadir 
Published: December 2023

Amaç: Bu çalışma, hemşirelerin işyeri nezaketsizliği ile karşılaşma durumları ve memnuniyet düzeylerine etkilerinin incelenmesi amacıyla yapıldı.
Gereç ve Yöntem: Araştırma tanımlayıcı ve kesitsel tiptedir. Araştırmanın örneklemini Eylül-Aralık 2020 tarihleri arasında Manisa Celal Bayar Üniversitesi Hafsa Sultan Hastanesinde çalışmaya katılmaya gönüllü olan hemşireler oluşturdu (n=313). Veriler Bilgi Formu, İşyeri Nezaketsizlik Ölçeği ve memnuniyet düzeyleri 0-10 indeksi ile toplandı. Verilerin analizi SPSS 22.0 programında yapıldı. Hemşirelerin sosyodemografik özellikleri ile ölçek puanları arasındaki ilişkiyi belirlemek için; Mann Whitney U, Kruskal Wallis ve Bonferroni düzeltmesi yapıldı. İşyeri Nezaketsizliği Ölçeği (İNÖ) ve çalışan memnuniyeti arasındaki ilişkinin belirlenmesi için de Spearman korelasyon analizi yapıldı.
Bulgular: Hemşirelerin yaş ortalaması 29,78±6,24, %78,9’u kadın ve %41,9’ u lisans mezunudur. Hemşirelerin İNÖ puan ortalaması 1,82±0,84 olarak bulundu. Hemşirelerin kurum memnuniyet ortalaması 7,49 ± 2,11; birim memnuniyet ortalaması ise 6,46 ± 2,09 olarak bulundu. Hemşirelerin nezaketsizlik ölçeği toplam puanları ile birim ve kurum memnuniyeti puanları arasında negatif yönde, orta düzey ve istatiksel olarak anlamlı ilişki bulundu (p