bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of ibudilast on thalamic volume in progressive multiple sclerosis
Authors: Nicholson Showly , Russo Andrew W , Brewer Kristina , Bien Heidi , Tobyne Sean M , Eloyan Ani , Klawiter Eric C 
Published: November 2023

Background: Thalamic volume loss is known to be associated with clinical and cognitive disability in progressive multiple sclerosis (PMS). Objective: To investigate the treatment effect of ibudilast on thalamic atrophy more than 96 weeks in the phase 2 trial in progressive(MS Secondary and Primary Progressive Ibudilast NeuroNEXT Trial in Multiple Sclerosis [SPRINT-MS]). Methods: A total of 231 participants were randomized to either ibudilast ( n = 114) or placebo ( n = 117). Thalamic volume change was computed using Bayesian Sequence Adaptive Multimodal Segmentation tool (SAMseg) incorporating T1, fluid-attenuated inversion recovery (FLAIR), and fractional anisotropy maps and analyzed with a mixed-effects repeated-measures model. Results: There was no significant difference in thalamic volumes between treatment groups. On exploratory analysis, participants with primary progressive multiple sclerosis (PPMS) on placebo had a 0.004% greater rate of thalamic atrophy than PPMS participants on ibudilast ( p = 0.058, 95% confidence interval (CI) = −0.008 to <0.001). Greater reductions in thalamic volumes at more than 96 weeks were associated with worsening multiple sclerosis functional composite (MSFC-4) scores ( p = 0.002) and worsening performance on the symbol digit modality test (SDMT) ( p < 0.001). Conclusion: In a phase 2 trial evaluating ibudilast in PMS, no treatment effect was demonstrated in preventing thalamic atrophy. Participants with PPMS exhibited a treatment effect that trended toward significance. Longitudinal changes in thalamic volume were related to worsening of physical and cognitive disability, highlighting this outcome’s clinical importance.
Long-term social assistance recipients’ experiences with an increased monthly payment: a qualitative pilot study
Authors: Torbjørnsen Astrid , Utne Inger , Løyland Borghild 
Published: November 2023

Aims: Ten long-term social assistance recipients in a Norwegian municipality received a greater-than-average fixed monthly payment for 12 months. This study aimed to explore whether these recipients with reduced administrative requirements and a fixed monthly payment that was greater than the average social assistance experienced reduced poverty, increased feelings of independence, better daily living, and an improved quality of life. Methods: The study’s explorative design included 20 qualitative, in-depth, semi-structured interviews and a longitudinal electronic survey for 12 months. The 10 participants had been selected by the local labour and welfare agency based on stringent criteria and are therefore not representative of social assistance recipients in general. Individual interviews were conducted during autumn 2021 and spring 2022. The interview data were analysed using systematic text condensation, and the survey results are presented using descriptive statistics. Results: The participants included in the project described a reduced experience of poverty. They could buy additional items and set aside money, something they had not been able to do in the past, and meant a great deal to them. They expressed experiencing freedom, gaining a stronger sense of independence, and having lessened feelings of shame. Many of the participants described health issues that were incompatible with working. Conclusions: Being given this opportunity led to a feeling of increased dignity and greater inclusion in society among this selected group of participants. They appreciated the simplified conditions and reduced requirements for administrative matters. All expressed that spending 8 months without contact with the social welfare office was a liberation.
Analysis of cord stress during tire dynamic longitudinal slip
Authors: Chen Luwen , Sun Pengfei , Zhou Shuiting , Meng Junling , Qian Chao , Sun Xin 
Published: November 2023

Selected 215/55 R17 radial tires for material test to obtain relevant material parameters. Used these parameters to build a finite element model and conduct longitudinal slip simulation. The relationship between longitudinal force and slip rate at different speeds and loads was determined by tire longitudinal slip tests. Then the longitudinal slip simulation results were compared with the test results to verify the feasibility of the model. The circumferential and axial rebar force of the belt layer at different speeds and the extreme value of the circumferential rebar force on the reverse-envelope of different skeleton materials were analyzed. The results show that: in the static state, the cord force of the belt layer had shown a trend consistent with the direction of the cord arrangement. As the speed increased, the belt cord force exhibited significant fluctuations and asymmetry. The rebar force of the turn-up points on the belt and ply is significantly smaller compared to the fetal crown ply. The rebar force at the fetal crown and belt wrapping points at 60 km/h was smaller than at 40 km/h and 80 km/h. The cord force of the fetal crown ply and the belt ply is much more affected by the load than that of the ply.
Teaching Chest Tube Insertion by Blended Learning: A Multi-Dimensional Analysis
Authors: Tokuno Junko , Valanci-Aroesty Sofia , Uchino Hayaki , Ghitulescu Gabriela , Sirois Christian , Kaneva Pepa , Fried Gerald M. , Carver Tamara E. 
Published: November 2023

Background Emerging technologies are being incorporated in surgical education. The use of such technology should be supported by evidence that the technology neither distracts nor overloads the learner and is easy to use. To teach chest tube insertion, we developed an e-learning module, as part of a blended learning program delivered prior to in-person hands-on simulation. This pilot study was aimed to assess learning effectiveness of this blended learning, and cognitive load and the usability of e-learning. Methods The interactive e-learning module with multimedia content was created following learning design principles. In advance of the standard simulation, 13 first-year surgical residents were randomized into two groups: 7 received the e-learning module and online reading materials (e-learning group); 6 received only the online reading materials (controls). Knowledge was evaluated by pre-and post-tests; technical performance was assessed using a Global Rating Scale by blinded assessors. Cognitive load and usability were evaluated using rating scales. Results The e-learning group showed significant improvement from baseline in knowledge ( P = .047), while controls did not ( P = .500). For technical skill, 100% of residents in the e-learning group reached a predetermined proficiency level vs 60% of controls ( P = .06). The addition of e-learning was associated with lower extrinsic and greater germane cognitive load ( P = .04, .03, respectively). Usability was evaluated highly by all participants in e-learning group. Conclusion Interactive e-learning added to hands-on simulation led to improved learning and desired cognitive load and usability. This approach should be evaluated in teaching of other procedural skills.
Correlation of circulating endothelial markers in COVID-19 patients admitted to the intensive care unit with laboratory data
Authors: Hakami Waleed , Dobie Gasim , Mobarki Abdullah A , Madkhali Aymen M , Akhter Mohmmad S. , Hakami Abdulrahim R , Nahari Mohammed H , Matari Yahya H , Essawi Khaled , Hakamy Ali , Algahtani Mohammad , Jackson Denise E , Hamali Hassan A 
Published: November 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still a global concern with high morbidity and mortality rates. The role of endothelial cells in the progress of COVID-19 is well established. Therefore, the current study aimed to measure the endothelial markers and their correlation with the hematological parameters in intensive care unit-admitted COVID-19 patients. This study involved 111 adult participants, including 55 ICU-admitted patients with COVID-19 and 56 healthy controls. Levels of E-selectin, ICAM-1, and VCAM-1 in the plasma of the study participants were measured and correlated with hematological parameters. The study demonstrates that COVID-19 patients admitted to the ICU have higher levels of E-selectin, ICAM-1, and VCAM-1 compared to healthy controls ( p < .05). These elevated levels can serve as reliable indicators of endothelial dysfunction and early markers for the detection and prediction of endothelial cell involvement in COVID-19 complications. The findings of this study suggest that increased levels of E-selectin, VCAM-1, and ICAM-1 in patients with COVID-19 are indicative of the participation of endothelial cells in the pathogenesis of COVID-19 complications. Consequently, these endothelial markers are proposed as potential early indicators for predicting the severity of COVID-19.
The views of people using homeless services about learning disability
Authors: McKenzie Karen , Robson Ruth , Murray George , Kaczmar Matt , Metcalfe Dale , Shirley Alex 
Published: November 2023

Aims People with a learning disability are at increased risk of becoming homeless, but little is known about how learning disability is viewed by people accessing homeless services. This study aimed to obtain the views of people experiencing homelessness about learning disability, in the context of a project that was exploring how to increase identification of learning disability. Methods A qualitative approach was used, and 19 adults were interviewed who were receiving support from homeless services in the North-East of England. Information from the interviews was analysed using thematic analysis. Results Four themes were identified relating to understanding of learning disability, the role of identification, day-to-day challenges, and experiences of services. Conclusion There is a need to: promote better understanding of learning disability; for early identification processes that involve the person in a meaningful way; and the provision of support that is non-stigmatising, practical and which addresses health concerns.
Parenting Behaviors and Parental self-efficacy: A comparative study of parents of children with intellectual disabilities and typically developing children
Authors: Laçin Emre , Doğan Betül Gökçen 
Published: November 2023

Purpose The aim of this study was to investigate the parenting behaviors and parental self-efficacy of parents of typically developing and child with an intellectual disability, considering their children’s groups of with or without intellectual disability and other relevant variables. The study involved 1194 parents with children aged 3-6 years, of whom 521 parents had children with intellectual disabilities and the remaining 673 parents had typically developing children. Method The data collection instruments used in this study were the Parental Behavior Scale Short Form and Parental Efficacy Scale. A t-test was used to compare parenting behavior and parental efficacy according to the child with or without an intellectual disability. In addition, MANOVA was used to compare parenting behavior and parental efficacy in relation to parents’ level of education and to examine the possible interaction effect between these two independent variables. Results The findings indicate that parents of typically developing children exhibit more positive parenting behaviors than parents of children with intellectual disabilities. However, the negative parenting behaviors of both groups were similar. In terms of parenting self-efficacy, parents of children with intellectual disabilities display higher self-efficacy than parents of typically developing children. The study also investigated whether there was a common effect in relation to child with or without an intellectual disability and parental education level, but no common effect was observed. Conclusion Positive parenting behaviors and parental self-efficacy differed according to whether child with or without an intellectual disability.
Cladonia rangiformis Acetone Extract— New Insight into the Chemical Composition and Biological Activity
Authors: Dimitrijević Ivana , Mitić Violeta , Stankov Jovanović Vesna , Stanković Miroslava , Zlatanović Ivana , Stojanović Gordana 
Published: November 2023

Introduction Cladonia rangiformis, also known as reindeer lichen, has been used for various remedies in folk medicine. The rich nutritional value of this lichen is reflected in the fact that it contains atranorin, which has been proven to have numerous biological activities. Objective The chemical composition, antioxidant, anticholinesterase, and antigenotoxic activities of the C. rangiformis acetone extract were investigated. The novelty of this work is that anticholinesterase activity, protective effect on human lymphocytes, and antioxidant activity by the cupric-reducing antioxidant capacity (CUPRAC) method of C. rangiformis extract were determined for the first time, as well as gas chromatography - mass spectrometry (GC-MS) profile. Methods Chemical composition was carried out by high-performance liquid chromatography (HPLC)-diode array detector and GC-MS. Antigenotoxic effect was evaluated in human lymphocytes by cytokinesis-block micronucleus assay. Total phenolic content, DPPH and ABTS radical scavenging capacities, CUPRAC, and total reducing power were determined spectrophotometrically. Determination of acetylcholinesterase activity was performed by Ellman's colorimetry assay. The statistical analysis of variance (One-way ANOVA) was performed using Origin software package version 7.0. Results HPLC method was used to identified 3 compounds with atranorin as predominant constituent (97.2%). Fumarprotocetraric and atraric acid were represented in a much smaller mutually approximate amount, 0.3 and 0.5%, respectively. Rangiformic acid was the most abundant volatile compound. Acetone extract of C. rangiformis (2 μg/mL) decreased the frequency of micronuclei by 15.5% while the radioprotectant amifostine reduced the frequency of occurrence of micronuclei by 11.4%. On the contrary, at a concentration of 1.0 mg/mL the extract exhibited an activating effect on cholinesterase (2.0%), while at a concentration of 10.0 mg/mL it showed a weak inhibitory effect (7.3%). The total phenol content was 132.71 μg gallic acid equivalents per mg of dry extract. The IC50 value for the DPPH experiment was 16.19 mg/mL and for ABTS was 11.80 mg/mL. Cupric reducing capacity and total reducing power were 17.81 μg Trolox equivalents per mg of dry extract and 0.45 μg ascorbic acid equivalents per mg of dry extract, respectively. Conclusion In addition to previously identified compounds in the acetone extract, atraric acid was identified for the first time by using HPLC method, and orcinol, β-orcinol, lauric alcohol, atranol, and rangiformic acid by using GC-MS method. The results of biological activity proved that acetone extract had antioxidant capacity and weak anticholinesterase activity. Reduction of the number of micronuclei in human lymphocytes, classified C. rangiformis as promising substances source with beneficial effects on DNA damage.
Heterogeneous Blockholders and Enterprise Innovation: Evidence From the Mixed-Ownership Reform in China
Authors: Xia Hui , Ling Shixian , Liu Zhangxin (Frank) 
Published: November 2023

The mixed ownership reform of China is a kind of further partial privatization for the listed state-owned enterprises (SOEs), and an opportunity for non-state-owned enterprises (non-SOEs) to expand their commerce boundaries. The purpose of this paper is to investigate the effect of heterogeneous blockholders on corporate innovation. Spanning the analysis with listed companies in China from 2007 to 2017, we find that heterogeneous blockholders have a significant positive effect on enterprise innovation. Lowering agency costs and improving corporate innovation efficiency are the two plausible mechanisms. From further research, we find that compared with non-SOEs, the positive effect of heterogeneous blockholders on enterprise innovation is more pronounced for SOEs, and the effect is more positive with the improvement of relative power balance between heterogeneous blockholders. The paper sheds light on the innovation effects of mixed-ownership reform in emerging and transitioning countries. JEL Classification: G32, M13, D23, G34
Peribronchiolar Metaplasia: A Marker of Cigarette Smoke-Induced Small Airway Injury in a Rural Cohort
Authors: Sangani Rahul G , Deepak Vishal , Ghio Andrew J , Patel Zalak , Alshaikhnassir Esra , Vos Jeffrey 
Published: November 2023

Background: Peribronchiolar metaplasia (PBM) is considered a reaction to injury characterized by the proliferation of bronchiolar epithelium into immediately adjacent alveolar walls. While an association of PBM with diffuse interstitial lung diseases has been recognized, the clinical significance of PBM remains uncertain. Methods: A cohort (n = 352) undergoing surgical resection of a lung nodule/mass in a rural area was retrospectively reviewed. Multivariate logistic regression analysis was performed to determine the association of PBM with clinical, physiological, radiographic, and histologic endpoints. Results: In the total study cohort, 9.1% were observed to have PBM as a histologic finding in resected lung tissue (n = 32). All but one of these patients with PBM were ever-smokers with a median of 42 pack years. Clinical COPD was diagnosed in two-thirds of patients with PBM. Comorbid gastroesophageal reflux disease (GERD) was significantly associated with PBM. All patients with PBM demonstrated radiologic and histologic evidence of emphysema. Measures of pulmonary function were not impacted by PBM. Mortality was not associated with the histologic observation of PBM. In a logistic regression model, centrilobular-ground glass opacity interstitial lung abnormality and traction bronchiectasis on the CT scan of the chest and histologic evidence of fibrosis, desquamative interstitial pneumonia and anthracosis all strongly predicted PBM in the cohort. Conclusion: A constellation of radiologic and histologic smoking-related abnormalities predicted PBM in study cohort. This confirms a co-existence of lung tissue responses to smoking including PBM, emphysema, and fibrosis. Acknowledging the physiologically “silent” nature of small airway dysfunction on pulmonary function testing, our findings support PBM as a histologic marker of small-airway injury associated with cigarette smoking.
Correlations between comorbidities in trials and the community: An individual-level participant data meta-analysis
Authors: Crowther Jamie , Butterly Elaine W , Hannigan Laurie J , Guthrie Bruce , Wild Sarah H , Mair Frances S , Hanlon Peter , Chadwick Fergus J , McAllister David A 
Published: November 2023

Background People with comorbidities are under-represented in randomised controlled trials, and it is unknown whether patterns of comorbidity are similar in trials and the community. Methods Individual-level participant data were obtained for 83 clinical trials (54,688 participants) for 16 index conditions from two trial repositories: Yale University Open Data Access (YODA) and the Centre for Global Clinical Research Data (Vivli). Community data (860,177 individuals) were extracted from the Secure Anonymised Information Linkage (SAIL) databank for the same index conditions. Comorbidities were defined using concomitant medications. For each index condition, we estimated correlations between comorbidities separately in trials and community data. For the six commonest comorbidities we estimated all pairwise correlations using Bayesian multivariate probit models, conditioning on age and sex. Correlation estimates from trials with the same index condition were combined into a single estimate. We then compared the trial and community estimates for each index condition. Results Despite a higher prevalence of comorbidities in the community than in trials, the correlations between comorbidities were mostly similar in both settings. On comparing correlations between the community and trials, 21% of correlations were stronger in the community, 10% were stronger in the trials and 68% were similar in both. In the community, 5% of correlations were negative, 21% were null, 56% were weakly positive and 18% were strongly positive. Equivalent results for the trials were 11%, 33%, 45% and 10% respectively. Conclusions Comorbidity correlations are generally similar in both the trials and community, providing some evidence for the reporting of comorbidity-specific findings from clinical trials.
Enhanced sensitivity of Au@Bi2WO6 flower-like materials to formaldehyde
Authors: Zhang Ruifeng , Liu Lei , Yang Weiye , Liu Yao , Liu Yingkai 
Published: November 2023

AbstractBi2WO6 flower-like materials (FMs) were prepared by a hydrothermal method, followed by an in-situ reduction method to prepare Au@Bi2WO6 FMs. X-ray diffraction, scanning electron microscopy, transmission electron microscopy, high-resolution transmission electron microscopy, and X-ray photoelectron spectroscopy were employed to characterize the samples. It was discovered that the calculated OV content of Au@Bi2WO6 FMs is 25.16% whereas that of Bi2WO6 FMs is 20.81%, offering appropriate active sites for the absorption of gases and thus enhancing outstanding sensing property. Moreover, the detection of volatile and hazardous substances such as formaldehyde, methanol, acetone, benzene, toluene, and xylene was carried out to assess the efficacy of the Au@Bi2WO6 FMs sensors. The optimal operating temperatures for the Bi2WO6 FMs and Au@Bi2WO6 FMs sensors were 290 and 260 °C, respectively. Compared with Au@Bi2WO6 FMs sensor and Bi2WO6 FMs one, the best response of the front was 250 (900)–100 (800) ppm formaldehyde whereas that of the latter was 90 (230). Therefore, Au@ Bi2WO6 FMs have good response and selectivity, which are promising candidates for formaldehyde detection.
Assessment of suicidal ideation via telemedicine: a case report and management suggestions
Authors: Accorsi Tarso Augusto Duenhas , De Amicis Lima Karine , Köhler Karen Francine , Cordioli Eduardo , Pedrotti Carlos Henrique Sartorato 
Published: November 2023

Abstract
Background
Nowadays, we find ourselves in very unexpected and challenging circumstances facing the COVID-19 pandemic. The impact of the new coronavirus pandemic probably affected everyone’s mental health, and people with pre-existing mental disorders may have an aggravated disease condition, leading to a suicide attempt. Pandemic also increased the use of direct-to-consumer telemedicine (TM) exponentially, and consequently, it was expected that cases of attempted suicide could be evaluated remotely. Some TM centers have adapted safety protocols from psychiatric guidelines for managing these patients. However, there is a lack of evidence of the effectiveness of follow-up by TM for patients at high risk for suicide, and there is no consensus on what action should be taken vis-à-vis the patient who requests immediate help remotely.

Case presentation
Here, we reported a case of a TM evaluation of a patient’s suicidal ideation in a direct-to-consumer telemedicine emergency center, describing the conduct taken in the face of this situation. We also discuss the importance of planning the emergency telemedicine center for situations of risk of suicide.

Conclusions
Telemedicine centers should be prepared for direct consumer assessment of suicidal ideation. Current management suggestions include recognizing the risk profile through institutional training and software skills and immediate referral for face-to-face assessment, encouraging continuous monitoring until the admission and active recruitment of family members or closest friends.